PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2555360-12	1989	Secondary amine mono-oxygenase is unique in its ability to function as cytochrome P-450 in activating molecular oxygen but to do so with a myoglobin-like active site.	Oxygen	21-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-87
2561421-8	1989	A type II beta-turn involving residues Thr6, Leu7, and Pro8 is well represented in the computed conformers as is a hydrogen bonding interaction between the NH of Leu3 and the carbonyl oxygen of Thr6.	Oxygen	184-190	beta-1,3-glucuronyltransferase 1	Homo sapiens	45-49
2557847-5	1989	It is proposed that sulphur-containing radicals resulting from attack of biologically-produced oxidants upon penicillamine in the presence of O2 can themselves inactivate alpha 1-antiproteinase, and that such radicals might contribute to the side-effects produced by penicillamine or gold thiol therapy in rheumatoid arthritis.	Oxygen	142-144	serpin family A member 1	Homo sapiens	171-193
2558583-11	1989	The role of increased activity of Cu,Zn SOD as an accompanying or a causative phenomenon in O2 tolerance of neonates could not be determined from these experiments.	Oxygen	92-94	superoxide dismutase 1	Rattus norvegicus	34-43
2691176-10	1989	During insulin infusion, adipose tissue glucose uptake increased and could account for more than 100% of oxygen uptake, implying storage of glucose.	Oxygen	105-111	insulin	Homo sapiens	7-14
2613366-7	1989	Maximal oxygen uptake was significantly different between conditions: 72.0 +/- 5.4 ml kg-1 min-1 at 20 degrees C; 68.9 +/- 5.1 ml kg-1 min-1 at 0 degree C and 68.5 +/- 4.6 ml kg-1 min-1 at -20 degrees C. Workload, time to exhaustion, glucose levels and rectal temperature decreased significantly at -20 degrees C. Catecholamines and lactate values were not significantly altered by thermal conditions after maximal exercise but the catecholamines were decreased during rest.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
2613366-7	1989	Maximal oxygen uptake was significantly different between conditions: 72.0 +/- 5.4 ml kg-1 min-1 at 20 degrees C; 68.9 +/- 5.1 ml kg-1 min-1 at 0 degree C and 68.5 +/- 4.6 ml kg-1 min-1 at -20 degrees C. Workload, time to exhaustion, glucose levels and rectal temperature decreased significantly at -20 degrees C. Catecholamines and lactate values were not significantly altered by thermal conditions after maximal exercise but the catecholamines were decreased during rest.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
2613366-7	1989	Maximal oxygen uptake was significantly different between conditions: 72.0 +/- 5.4 ml kg-1 min-1 at 20 degrees C; 68.9 +/- 5.1 ml kg-1 min-1 at 0 degree C and 68.5 +/- 4.6 ml kg-1 min-1 at -20 degrees C. Workload, time to exhaustion, glucose levels and rectal temperature decreased significantly at -20 degrees C. Catecholamines and lactate values were not significantly altered by thermal conditions after maximal exercise but the catecholamines were decreased during rest.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
2816756-3	1989	In the DO2 range between 300 and 450 ml/min/m2, in which the DO2 of 32 survivors and 11 nonsurvivors overlapped, the P50 of nonsurvivors was significantly higher than that of survivors (31.5 +/- 1.6 vs 27.9 +/- 1.5 torr, p less than 0.001), but there were no significant differences in any other oxygen transport variable.	Oxygen	296-302	nuclear factor kappa B subunit 1	Homo sapiens	117-120
2590239-5	1989	Furthermore, the dimethylarsine-induced breaks were diminished by the addition of SOD and catalase, suggesting that active oxygen produced by dimethylarsine was involved in the induction of DNA damage.	Oxygen	123-129	catalase	Mus musculus	82-98
2816756-6	1989	Nevertheless, the interpretation of an increased P50 in patients with acute myocardial infarction must be made with caution, even with adequate DO2 and VO2, because it may imply a precarious oxygen transport/requirement balance in peripheral tissue and, hence, a fatal outcome.	Oxygen	191-197	nuclear factor kappa B subunit 1	Homo sapiens	49-52
2809506-9	1989	In exercise tests the aerobic capacity and oxygen uptake increased during EPO therapy.	Oxygen	43-49	erythropoietin	Homo sapiens	74-77
2560462-0	1989	Involvement of reactive oxygen metabolites in the candidacidal activity of human neutrophils stimulated by muramyl dipeptide or tumor necrosis factor.	Oxygen	24-30	tumor necrosis factor	Homo sapiens	128-149
2560462-7	1989	Inhibition by sodium azide and sodium benzoate indicated that these oxygen metabolites could be derived from the MPO-halide system but also from hydroxyl radical production.	Oxygen	68-74	myeloperoxidase	Homo sapiens	113-116
2515923-8	1989	Tonometry of blood samples from patients may also be used in the determination of acid-base quantities and hemoglobin-oxygen affinity, e.g. p50.	Oxygen	118-124	nuclear factor kappa B subunit 1	Homo sapiens	140-143
9991444-0	1989	Structure and oxygen stoichiometry for the electron-doped cuprate superconductor Nd1.85Ce0.15CuO4- delta.	Oxygen	14-20	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	81-84
2682012-6	1989	Systemic oxygen uptake was significantly greater at 2.0 than 1.5 L.min-1 m-2 by 18 (7, 30) ml.min-1.m-2, whereas it was not significantly affected by change in flow character (-4[-16, 7] ml.min-1.min-2) or arterial pH (-2 [-12, 8] ml.min-1.m-2 per 0.1 pH unit).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	67-72
2682012-6	1989	Systemic oxygen uptake was significantly greater at 2.0 than 1.5 L.min-1 m-2 by 18 (7, 30) ml.min-1.m-2, whereas it was not significantly affected by change in flow character (-4[-16, 7] ml.min-1.min-2) or arterial pH (-2 [-12, 8] ml.min-1.m-2 per 0.1 pH unit).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
2682012-6	1989	Systemic oxygen uptake was significantly greater at 2.0 than 1.5 L.min-1 m-2 by 18 (7, 30) ml.min-1.m-2, whereas it was not significantly affected by change in flow character (-4[-16, 7] ml.min-1.min-2) or arterial pH (-2 [-12, 8] ml.min-1.m-2 per 0.1 pH unit).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
2682012-6	1989	Systemic oxygen uptake was significantly greater at 2.0 than 1.5 L.min-1 m-2 by 18 (7, 30) ml.min-1.m-2, whereas it was not significantly affected by change in flow character (-4[-16, 7] ml.min-1.min-2) or arterial pH (-2 [-12, 8] ml.min-1.m-2 per 0.1 pH unit).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	196-201
2682012-6	1989	Systemic oxygen uptake was significantly greater at 2.0 than 1.5 L.min-1 m-2 by 18 (7, 30) ml.min-1.m-2, whereas it was not significantly affected by change in flow character (-4[-16, 7] ml.min-1.min-2) or arterial pH (-2 [-12, 8] ml.min-1.m-2 per 0.1 pH unit).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
2682012-12	1989	A flow rate of 1.5 L.min-1.m-2 during cardiopulmonary bypass with moderate hypothermia results in a less than maximal systemic oxygen uptake.	Oxygen	127-133	CD59 molecule (CD59 blood group)	Homo sapiens	21-26
2560953-6	1989	The results of the experiment showed that ESOD activity after ischemia and reperfusion was decreased and the addition of oxygen free radical scavengers (SOD and CAT) to the cardioplegic solution and the reperfusates greatly reduced the leakage of myocardial enzymes, coronary vascular resistance, and the ultrastructural damages of the myocardium.	Oxygen	121-127	catalase	Homo sapiens	161-164
2818619-2	1989	The enzyme-mediated microsomal alkylation required NADPH and oxygen and was inhibited by carbon monoxide, indicating the participation of a cytochrome P-450-dependent monooxygenase.	Oxygen	61-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-156
2818623-4	1989	Covalent binding to hamster liver microsomes required NADPH and oxygen; it was decreased in the presence of the cytochrome P-450 inhibitors, carbon monoxide, piperonyl butoxide (4 mM), and SKF 525-A (4 mM) or in the presence of the nucleophile, glutathione (1 or 4 mM).	Oxygen	64-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-128
2793057-1	1989	Catalase activity was determined in human semen by measuring the oxygen burst with a Clark electrode, after H2O2 addition.	Oxygen	65-71	catalase	Homo sapiens	0-8
2793057-2	1989	Significant catalase activities (mean +/- SD) were found in migrated, motile spermatozoa (44 +/- 17 nmoles O2/min/10(8) cells) and in seminal plasma of normozoospermic men (129 +/- 59 nmoles O2/min/ml).	Oxygen	107-109	catalase	Homo sapiens	12-20
2793057-2	1989	Significant catalase activities (mean +/- SD) were found in migrated, motile spermatozoa (44 +/- 17 nmoles O2/min/10(8) cells) and in seminal plasma of normozoospermic men (129 +/- 59 nmoles O2/min/ml).	Oxygen	191-193	catalase	Homo sapiens	12-20
2560953-7	1989	These results suggest that the use of SOD and CAT may inhibit myocardial reperfusion injury by scavenging oxygen-derived free radicals.	Oxygen	106-112	catalase	Homo sapiens	46-49
2561133-5	1989	These results suggest that the replacement of a carbon atom into an oxygen atom in the side chain structure of 1,25-D3 results significant decrease in the binding affinity to DBP and that 22-oxa-1,25-D3 is transported as a complex-form not with DBP but with lipoprotein to the target tissues.	Oxygen	68-74	D-box binding PAR bZIP transcription factor	Homo sapiens	175-178
2807522-7	1989	2-Chloroadenosine inhibited O2 consumption stimulated by STZ and the surrogate bacterial chemoattractant FMLP; however, inhibition of O2 consumption varied with the presence or absence of cytochalasin B.	Oxygen	28-30	formyl peptide receptor 1	Homo sapiens	105-109
2600595-0	1989	Demethylation of tertiary amines by a reconstituted cytochrome P-450 enzyme system: kinetics of oxygen consumption and hydrogen peroxide formation.	Oxygen	96-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-68
2561133-5	1989	These results suggest that the replacement of a carbon atom into an oxygen atom in the side chain structure of 1,25-D3 results significant decrease in the binding affinity to DBP and that 22-oxa-1,25-D3 is transported as a complex-form not with DBP but with lipoprotein to the target tissues.	Oxygen	68-74	D-box binding PAR bZIP transcription factor	Homo sapiens	245-248
2600595-1	1989	Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates.	Oxygen	26-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-98
2575679-3	1989	In order to elucidate the relationship between release of these enzymes and renal ischemic injury, we devised an in vitro model of anoxic injuries to renal tubular cells and measured the time-course release of NAG (a lysosomal enzyme), gamma-GTP and LAP (brush border enzymes) at 37 degrees C under five different aerobic and anaerobic conditions (95% O2, 20% O2, 10% O2, 3% O2 and 0% O2).	Oxygen	352-354	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
2575679-3	1989	In order to elucidate the relationship between release of these enzymes and renal ischemic injury, we devised an in vitro model of anoxic injuries to renal tubular cells and measured the time-course release of NAG (a lysosomal enzyme), gamma-GTP and LAP (brush border enzymes) at 37 degrees C under five different aerobic and anaerobic conditions (95% O2, 20% O2, 10% O2, 3% O2 and 0% O2).	Oxygen	360-362	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
2575679-3	1989	In order to elucidate the relationship between release of these enzymes and renal ischemic injury, we devised an in vitro model of anoxic injuries to renal tubular cells and measured the time-course release of NAG (a lysosomal enzyme), gamma-GTP and LAP (brush border enzymes) at 37 degrees C under five different aerobic and anaerobic conditions (95% O2, 20% O2, 10% O2, 3% O2 and 0% O2).	Oxygen	360-362	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
2575679-5	1989	In the 3% O2, 10% O2 and 20% O2 groups, NAG, gamma-GTP and LAP were released into the media at a similar rate to that in the 95% O2 group, and anaerobic damage to the renal tubular cells was not observed.	Oxygen	18-20	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43
2575679-3	1989	In order to elucidate the relationship between release of these enzymes and renal ischemic injury, we devised an in vitro model of anoxic injuries to renal tubular cells and measured the time-course release of NAG (a lysosomal enzyme), gamma-GTP and LAP (brush border enzymes) at 37 degrees C under five different aerobic and anaerobic conditions (95% O2, 20% O2, 10% O2, 3% O2 and 0% O2).	Oxygen	360-362	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
2575679-3	1989	In order to elucidate the relationship between release of these enzymes and renal ischemic injury, we devised an in vitro model of anoxic injuries to renal tubular cells and measured the time-course release of NAG (a lysosomal enzyme), gamma-GTP and LAP (brush border enzymes) at 37 degrees C under five different aerobic and anaerobic conditions (95% O2, 20% O2, 10% O2, 3% O2 and 0% O2).	Oxygen	360-362	N-acetyl-alpha-glucosaminidase	Homo sapiens	210-213
2584778-14	1989	In vitro studies revealed that human immunoglobulin denatured by O2 bubbling produced C4a, C3a, and C5a in a dose dependent manner, although human albumin treated identically as human immunoglobulin did not produce them.	Oxygen	65-67	complement C5a receptor 1	Homo sapiens	100-103
2575679-5	1989	In the 3% O2, 10% O2 and 20% O2 groups, NAG, gamma-GTP and LAP were released into the media at a similar rate to that in the 95% O2 group, and anaerobic damage to the renal tubular cells was not observed.	Oxygen	10-12	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43
2575679-5	1989	In the 3% O2, 10% O2 and 20% O2 groups, NAG, gamma-GTP and LAP were released into the media at a similar rate to that in the 95% O2 group, and anaerobic damage to the renal tubular cells was not observed.	Oxygen	18-20	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43
2575679-5	1989	In the 3% O2, 10% O2 and 20% O2 groups, NAG, gamma-GTP and LAP were released into the media at a similar rate to that in the 95% O2 group, and anaerobic damage to the renal tubular cells was not observed.	Oxygen	18-20	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43
2575679-6	1989	In the 0% O2 group, the NAG in the medium increased from 60 to 180 min at a significantly higher rate than that of the 95% O2 group, and a linear relationship was observed between NAG concentration and incubation time (r = 0.73), although NAG did not increase significantly at 30 min.	Oxygen	10-12	N-acetyl-alpha-glucosaminidase	Homo sapiens	24-27
2575679-6	1989	In the 0% O2 group, the NAG in the medium increased from 60 to 180 min at a significantly higher rate than that of the 95% O2 group, and a linear relationship was observed between NAG concentration and incubation time (r = 0.73), although NAG did not increase significantly at 30 min.	Oxygen	10-12	N-acetyl-alpha-glucosaminidase	Homo sapiens	180-183
2575679-6	1989	In the 0% O2 group, the NAG in the medium increased from 60 to 180 min at a significantly higher rate than that of the 95% O2 group, and a linear relationship was observed between NAG concentration and incubation time (r = 0.73), although NAG did not increase significantly at 30 min.	Oxygen	10-12	N-acetyl-alpha-glucosaminidase	Homo sapiens	180-183
2550081-12	1989	Both the arrhythmia and the free radical signal were partially blocked by SOD, catalase and ICRF-187, indicating that iron-dependent oxygen radical formation from BMY-25282 (and possibly other compounds) is involved, in part, in inducing toxic manifestations in the rat heart and possibly in clinic.	Oxygen	133-139	catalase	Rattus norvegicus	79-87
2504483-4	1989	Thiotepa was shown to be metabolized under these conditions in a NADPH- and O2-dependent reaction that was catalyzed by one or more microsomal cytochrome P-450 enzymes that were present in the S-9 fraction.	Oxygen	76-78	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	143-159
2504483-9	1989	These findings establish that the cytotoxic effects of thiotepa are oxygen dependent and may involve, at least in part, metabolic processes catalyzed by cytochrome P-450 enzymes.	Oxygen	68-74	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-169
2805781-0	1989	The role of toxic oxygen metabolites in interleukin-2-induced vascular leak syndrome.	Oxygen	18-24	interleukin 2	Homo sapiens	40-53
2814975-4	1989	Recently it has been shown that the immuno-modulating compound interferon-gamma can stimulate oxygen metabolism in the phagocytes of these patients.	Oxygen	94-100	interferon gamma	Homo sapiens	63-79
2551190-7	1989	Superoxide dismutase, catalase, and D-mannitol showed protective effects on the sulfhydryl group depression by O2-., H2O2, and .OH, respectively.	Oxygen	111-115	catalase	Rattus norvegicus	22-30
2670646-9	1989	The insulin-induced shift from myocardial free fatty acid to carbohydrate usage may be beneficial to the ischemic heart by increasing glycogen stores, saving oxygen, and inhibiting an excess free-fatty acid concentration, which may be toxic during ischemia.	Oxygen	158-164	insulin	Homo sapiens	4-11
2503544-15	1989	Reduced oxygen concentration decreased the ability of IFN-gamma to inhibit tumor cell growth in vitro.	Oxygen	8-14	interferon gamma	Homo sapiens	54-63
2806500-5	1989	Indeed, since the oxygen flow rate cannot be reliably increased over 3 l.min-1 with the available oxygen concentrators, the reservoir device could be more effective in some selected patients whose hypoxaemia cannot be adequately corrected by standard nasal prongs.	Oxygen	18-24	CD59 molecule (CD59 blood group)	Homo sapiens	73-78
2806500-5	1989	Indeed, since the oxygen flow rate cannot be reliably increased over 3 l.min-1 with the available oxygen concentrators, the reservoir device could be more effective in some selected patients whose hypoxaemia cannot be adequately corrected by standard nasal prongs.	Oxygen	98-104	CD59 molecule (CD59 blood group)	Homo sapiens	73-78
2549408-9	1989	The addition of catalase slowed down oxygen consumption by 31% and this data taken together with our previous observations on the model implicate hydrogen peroxide as a key intermediate in DNA damage caused by hydroxyl free radical.	Oxygen	37-43	catalase	Homo sapiens	16-24
2770760-2	1989	The majority of the DNA breaks induced were abolished by catalase indicating a role for active oxygen species.	Oxygen	95-101	catalase	Homo sapiens	57-65
2690426-1	1989	Cytochrome P-450 appears to catalyse most monooxygenation reactions by sequential one-electron steps rather than by a single, concerted transfer of the ferryl oxygen to the substrate.	Oxygen	46-52	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
2503544-0	1989	Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.	Oxygen	106-112	interferon gamma	Homo sapiens	35-51
2753040-1	1989	Heme compounds, in combination with a reducing agent and oxygen, can express various activities of cytochrome P-450 enzymes.	Oxygen	57-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	99-115
2619999-2	1989	In the present study, we demonstrate that exposure to 85% oxygen increased alveolar lavage and lung SP-A, and that these increases were related to increased SP-A synthesis and mRNA.	Oxygen	58-64	surfactant protein A1	Rattus norvegicus	100-104
2619999-2	1989	In the present study, we demonstrate that exposure to 85% oxygen increased alveolar lavage and lung SP-A, and that these increases were related to increased SP-A synthesis and mRNA.	Oxygen	58-64	surfactant protein A1	Rattus norvegicus	157-161
2619999-5	1989	SP-A-specific mRNA increased in the lungs of rats exposed to oxygen, occurring with a time course similar to the increase in tissue SP-A.	Oxygen	61-67	surfactant protein A1	Rattus norvegicus	0-4
2619999-7	1989	Synthesis of SP-A was increased 2- to 3-fold and secretion was increased 6- to 7-fold by type II epithelial cells isolated from oxygen-exposed rats.	Oxygen	128-134	surfactant protein A1	Rattus norvegicus	13-17
2771902-7	1989	In sarcoidosis there is a positive correlation between the oxygen radical release of AM and the CD4/CD8 ratio of BAL lymphocytes.	Oxygen	59-65	CD4 molecule	Homo sapiens	96-99
11538350-1	1989	Observations of nine oxygen- and sulfur-containing organic molecules have been made toward the cold dark clouds TMC-1 and L134N.	Oxygen	21-27	transmembrane channel like 1	Homo sapiens	112-117
2792084-6	1989	A network of seven hydrogen bonds connects oxygen atoms O-3, O-4, O-5 and O-6 of the mannoside to residues Asn14, Leu99, Tyr100, Asp208 and Arg228.	Oxygen	43-49	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	56-59
2500510-5	1989	With glucose loading, infants with bronchopulmonary dysplasia had a significant rise in basal oxygen consumption (7.91 +/- 0.91 ml.kg-1.min-1 to 9.65 +/- 1.35 ml.kg-1.min-1, p less than 0.05), basal carbon dioxide production (5.93 +/- 0.72 ml.kg-1.min-1 to 7.10 +/- 1.04 ml.kg-1.min-1), and resting energy expenditure (53.8 +/- 5.75 kcal.kg-1.24 hr-1 to 65.3 +/- 7.0 kcal.kg-1.24 hr-1, all p values less than 0.05).	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
2552754-2	1989	Near-IR emission spectra from the myeloperoxidase and lactoperoxidase enzymatic systems show only emission of singlet oxygen at 1268 nm.	Oxygen	118-124	myeloperoxidase	Homo sapiens	34-49
2668254-6	1989	Insulin action on glucose uptake and tyrosine release of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium.	Oxygen	296-298	insulin	Homo sapiens	0-7
2500510-5	1989	With glucose loading, infants with bronchopulmonary dysplasia had a significant rise in basal oxygen consumption (7.91 +/- 0.91 ml.kg-1.min-1 to 9.65 +/- 1.35 ml.kg-1.min-1, p less than 0.05), basal carbon dioxide production (5.93 +/- 0.72 ml.kg-1.min-1 to 7.10 +/- 1.04 ml.kg-1.min-1), and resting energy expenditure (53.8 +/- 5.75 kcal.kg-1.24 hr-1 to 65.3 +/- 7.0 kcal.kg-1.24 hr-1, all p values less than 0.05).	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
2500510-5	1989	With glucose loading, infants with bronchopulmonary dysplasia had a significant rise in basal oxygen consumption (7.91 +/- 0.91 ml.kg-1.min-1 to 9.65 +/- 1.35 ml.kg-1.min-1, p less than 0.05), basal carbon dioxide production (5.93 +/- 0.72 ml.kg-1.min-1 to 7.10 +/- 1.04 ml.kg-1.min-1), and resting energy expenditure (53.8 +/- 5.75 kcal.kg-1.24 hr-1 to 65.3 +/- 7.0 kcal.kg-1.24 hr-1, all p values less than 0.05).	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
2500510-5	1989	With glucose loading, infants with bronchopulmonary dysplasia had a significant rise in basal oxygen consumption (7.91 +/- 0.91 ml.kg-1.min-1 to 9.65 +/- 1.35 ml.kg-1.min-1, p less than 0.05), basal carbon dioxide production (5.93 +/- 0.72 ml.kg-1.min-1 to 7.10 +/- 1.04 ml.kg-1.min-1), and resting energy expenditure (53.8 +/- 5.75 kcal.kg-1.24 hr-1 to 65.3 +/- 7.0 kcal.kg-1.24 hr-1, all p values less than 0.05).	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
18588055-5	1989	The heat generated per mole of oxygen taken up stayed quite close to the fully aerobic value of 506 kJ mol(-1) even when a sizable fraction of the substrate available to catabolism was fermented.	Oxygen	31-37	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	103-109
2780507-3	1989	Catalase and superoxide dismutase additions inhibited oxygen consumption for all tested anthracyclines and diethylenetriaminepentacetic acid (DTPA) was also inhibitory except for demethoxydaunorubicin.	Oxygen	54-60	catalase	Homo sapiens	0-8
2499234-5	1989	We conclude that with exposure to 100% O2, retrosternal pain, presumably from tracheal inflammation, occurs before detectable abnormalities of epithelial solute permeability (Tc-DTPA clearance), endothelial O2 injury (fibronectin concentration and Factor VIII), or pulmonary function.	Oxygen	39-41	fibronectin 1	Homo sapiens	218-229
2672691-9	1989	Oxygen radical scavengers such as superoxide dismutase and catalase protect the body against normal levels of oxygen-free radicals.	Oxygen	110-116	catalase	Homo sapiens	59-67
2735938-4	1989	In perfused livers of BrCCl3-treated rats, the efflux of Ca2+ and the concomitant stimulation of O2 consumption and glucose release induced by vasopressin were decreased.	Oxygen	97-99	arginine vasopressin	Rattus norvegicus	143-154
2735396-3	1989	The falling respiratory rate at the lower pressures gives rise to an oxygen pressure for half-maximal respiration (P50) of approximately 0.8 Torr, which is consistent with the 0.5 Torr value for suspensions of isolated mitochondria in the presence of ATP (J. Biol.	Oxygen	69-75	nuclear factor kappa B subunit 1	Homo sapiens	115-118
2735396-9	1989	Thus, for cells treated with uncoupler, the P50 appears to be limited by oxygen diffusion from the external medium to the mitochondria.	Oxygen	73-79	nuclear factor kappa B subunit 1	Homo sapiens	44-47
2764272-1	1989	The Oxytron (Weinmann, Hamburg, FRG) electronic oxygen conserver (patent pending) is a new device designed to deliver precise amounts of oxygen at the optimum point in the breathing cycle via a nasal cannula.	Oxygen	48-54	FERM, ARH/RhoGEF and pleckstrin domain protein 2	Homo sapiens	32-35
2764272-1	1989	The Oxytron (Weinmann, Hamburg, FRG) electronic oxygen conserver (patent pending) is a new device designed to deliver precise amounts of oxygen at the optimum point in the breathing cycle via a nasal cannula.	Oxygen	137-143	FERM, ARH/RhoGEF and pleckstrin domain protein 2	Homo sapiens	32-35
2502602-7	1989	Tonometry of blood samples from patients may also be used in the determination of acid-base quantities and hemoglobin-oxygen affinity e.g. p50.	Oxygen	118-124	nuclear factor kappa B subunit 1	Homo sapiens	139-142
2471603-5	1989	Oxygen production by the catalase is measured on-line, with the electrode in contact with hydrogen peroxide.	Oxygen	0-6	catalase	Homo sapiens	25-33
2543978-3	1989	Profiles of the local oxygen transport parameter across the membrane were obtained as a function of cholesterol mol fraction and temperature in L-alpha-dimyristoylphosphatidylcholine ([ Myr2]PtdCho) and L-alpha-dioleoylphosphatidylcholine ([ Ole2]PtdCho) membranes.	Oxygen	22-28	myosin IC	Homo sapiens	186-190
2732620-7	1989	We conclude that in the diseased kidney, a high-protein diet, perhaps by increasing renal O2 consumption, directly stimulates erythropoietin production.	Oxygen	90-92	erythropoietin	Homo sapiens	126-140
2550701-3	1989	The role of MPO and its possible pathogenetic action as a generator of the active forms of oxygen in atherosclerosis and its complications has been discussed.	Oxygen	91-97	myeloperoxidase	Homo sapiens	12-15
2637948-3	1989	Oxygen utilization by the hindlimb rose during reperfusion from a baseline in the control group of 2.4 +/- 0.3 ml 02/min to 5.4 +/- 1.1 during the first 10 minutes and plateaued at 3.5 +/- 1.3 by the first hour with no differences in the SOD/CAT group.	Oxygen	0-6	catalase	Canis lupus familiaris	242-245
2543978-5	1989	At approximately 30 degrees C, the oxygen permeability coefficients in the presence and absence of 50 mol % cholesterol are 22.7 and 125.2 cm/s, respectively, for [Myr2]PtdCho membranes, and 54.7 and 114.2 cm/s, respectively, for [Ole2]PtdCho membranes (compared with 60-80 cm/s for water layers with the same thicknesses as the membranes).	Oxygen	35-41	myosin IC	Homo sapiens	164-168
2543984-12	1989	This study shows that (i) SOD and catalase are highly effective in blocking free radical reactions in vivo, (ii) the radicals generated in the "stunned" myocardium are derived from univalent reduction of O2, and (iii) inhibition of radical reactions improves functional recovery.	Oxygen	204-206	catalase	Canis lupus familiaris	34-42
2656688-1	1989	The Saccharomyces cerevisiae anaerobic gene (ANB1) is negatively regulated both by oxygen and heme.	Oxygen	83-89	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	45-49
2656688-2	1989	A 299-base pair-long fragment from the 5"-flanking region of the ANB1 gene was found to confer oxygen-mediated negative regulation to an heterologous CYC1-LacZ hybrid gene.	Oxygen	95-101	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	65-69
2656688-7	1989	A model to explain the negative regulation of the ANB1 gene by oxygen and heme is proposed.	Oxygen	63-69	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	50-54
2540860-1	1989	Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN).	Oxygen	66-72	myeloperoxidase	Homo sapiens	0-15
2765498-1	1989	Oxygen-dependent induction of ethanol-inducible cytochrome P-450 (IIE1) in rat liver and lung.	Oxygen	0-6	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-70
2765498-10	1989	The results reached indicate a role for cytochrome P-450 and, in particular, for cytochrome P-450IIE1 in oxygen-mediated tissue toxicity.	Oxygen	105-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-56
2540860-1	1989	Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN).	Oxygen	66-72	myeloperoxidase	Homo sapiens	17-20
2495865-1	1989	The prostaglandin H synthase (PHS)-catalyzed metabolism of indenestrol A (IA), indenestrol B (IB) and indanestrol (I) and the effects of these compounds on PHS were studied in incubations with ram seminal vesicle microsomes (RSVM) by means of arachidonic acid (20:4)-dependent oxygen consumption and by HPLC analysis of parent compound conversion as well as UV spectroscopy.	Oxygen	277-283	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	4-28
2719238-6	1989	The mean FIO2 at a ventilation of 4.5 l.min-1 and 8 l.min-1 oxygen flow was 78% and this fell to 27% at a ventilation of 16 l.min-1 and oxygen flow of 2 l.min-1.	Oxygen	60-66	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
2719238-6	1989	The mean FIO2 at a ventilation of 4.5 l.min-1 and 8 l.min-1 oxygen flow was 78% and this fell to 27% at a ventilation of 16 l.min-1 and oxygen flow of 2 l.min-1.	Oxygen	60-66	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
2719238-6	1989	The mean FIO2 at a ventilation of 4.5 l.min-1 and 8 l.min-1 oxygen flow was 78% and this fell to 27% at a ventilation of 16 l.min-1 and oxygen flow of 2 l.min-1.	Oxygen	60-66	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
2495865-1	1989	The prostaglandin H synthase (PHS)-catalyzed metabolism of indenestrol A (IA), indenestrol B (IB) and indanestrol (I) and the effects of these compounds on PHS were studied in incubations with ram seminal vesicle microsomes (RSVM) by means of arachidonic acid (20:4)-dependent oxygen consumption and by HPLC analysis of parent compound conversion as well as UV spectroscopy.	Oxygen	277-283	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	30-33
2740616-1	1989	Trimetazidine at concentrations above 100 microM competed with cytochrome c in scavenging O2.- radicals formed by the reaction catalyzed by the xanthine oxidase enzyme upon xanthine.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	63-75
2469960-2	1989	During respiration, an exogenous donor, cytochrome c, donates four electrons to O2 bound at the bimetallic haem alpha 3 Fe-Cu centre within the enzyme.	Oxygen	80-82	cytochrome c, somatic	Homo sapiens	40-52
2546055-6	1989	In conjunction with the oxygen-heme response, we determined that the product of the ROX1 gene, a trans-acting regulator of several yeast genes controlled by oxygen, is also involved in COX5 expression.	Oxygen	24-30	Rox1p	Saccharomyces cerevisiae S288C	84-88
2546055-6	1989	In conjunction with the oxygen-heme response, we determined that the product of the ROX1 gene, a trans-acting regulator of several yeast genes controlled by oxygen, is also involved in COX5 expression.	Oxygen	157-163	Rox1p	Saccharomyces cerevisiae S288C	84-88
2540843-2	1989	As in the case of phenylacetaldehyde, the Schiff base undergoes an intracellular, myeloperoxidase-catalyzed, oxygen-consuming process.	Oxygen	109-115	myeloperoxidase	Homo sapiens	82-97
2740616-2	1989	This scavenger effect was also observed when O2.- were generated by active human neutrophils in which the rate of O2.- formation was monitored by following the reduction of cytochrome c or the emission of luminol-dependent chemiluminescence.	Oxygen	45-47	cytochrome c, somatic	Homo sapiens	173-185
2740616-2	1989	This scavenger effect was also observed when O2.- were generated by active human neutrophils in which the rate of O2.- formation was monitored by following the reduction of cytochrome c or the emission of luminol-dependent chemiluminescence.	Oxygen	114-116	cytochrome c, somatic	Homo sapiens	173-185
2550115-8	1989	After oxygen treatment, ATII of the patients with PaO2 greater than 8.0 kPa was lower than that of the patients with PaO2 less than 8.0 kPa, but ACE and PRA of the former were lower than those of the latter.	Oxygen	6-12	angiotensinogen	Homo sapiens	24-28
2777635-1	1989	Superoxide dismutase (SOD) is a "scavenger" enzyme which catalyses the dismutation (reduction-oxidation) of the superoxide anion (O2-.	Oxygen	130-132	superoxide dismutase 1	Homo sapiens	0-20
2777635-1	1989	Superoxide dismutase (SOD) is a "scavenger" enzyme which catalyses the dismutation (reduction-oxidation) of the superoxide anion (O2-.	Oxygen	130-132	superoxide dismutase 1	Homo sapiens	22-25
2777635-6	1989	In the upper regions of the epiphyseal cartilage (the zones of proliferation and maturation), where the vascularity is poor and the oxygen tension low, SOD activity was localized within the chondrocytes.	Oxygen	132-138	superoxide dismutase 1	Homo sapiens	152-155
2777635-9	1989	Thus, the distribution of SOD enzyme activity in this tissue seems to vary in accordance with the level of oxygen present.	Oxygen	107-113	superoxide dismutase 1	Homo sapiens	26-29
2524868-3	1989	Severe hypoxia induced by 10% O2 breathing increased the mean pulmonary arterial pressure (Ppa) by 11.6 mm Hg within 10 min (P less than 0.01), accompanying a slight but significant rise in plasma ANP level of pulmonary artery (PA) from 24.3 +/- 5.3 to 28.2 +/- 4.6 pg/ml (P less than 0.05).	Oxygen	30-32	natriuretic peptide A	Homo sapiens	197-200
2550115-13	1989	Also the concentration of ATII was related to the prognosis of the patients, and merely supplying the patient with oxygen cannot restore normal ATII.	Oxygen	115-121	angiotensinogen	Homo sapiens	26-30
2550115-13	1989	Also the concentration of ATII was related to the prognosis of the patients, and merely supplying the patient with oxygen cannot restore normal ATII.	Oxygen	115-121	angiotensinogen	Homo sapiens	144-148
2703531-2	1989	The synthesis of Cu,Zn SOD by rat lung increases spontaneously in the fetus in late gestation and during exposure of neonatal and adult rats to greater than 95% O2.	Oxygen	161-163	superoxide dismutase 1	Rattus norvegicus	17-26
2550115-8	1989	After oxygen treatment, ATII of the patients with PaO2 greater than 8.0 kPa was lower than that of the patients with PaO2 less than 8.0 kPa, but ACE and PRA of the former were lower than those of the latter.	Oxygen	6-12	angiotensin I converting enzyme	Homo sapiens	145-148
2646944-5	1989	There was a positive correlation before training between maximum O2 uptake (Vo2 max) and total body glucose disposal rate (M) at the 40 mU.m-2.min-1 insulin infusion (r = 0.69, P less than 0.02).	Oxygen	65-67	CD59 molecule (CD59 blood group)	Homo sapiens	143-148
2917971-2	1989	Cytochrome P-450 is known to catalyze the following oxygen transfer reaction: RH + PhIO----ROH + PhI where RH represents a variety of hydroxylatable substrates and PhIO a variety of iodosobenzene derivatives that serve as oxygen donors, and neither molecular oxygen nor an external electron donor is required.	Oxygen	52-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
2917971-2	1989	Cytochrome P-450 is known to catalyze the following oxygen transfer reaction: RH + PhIO----ROH + PhI where RH represents a variety of hydroxylatable substrates and PhIO a variety of iodosobenzene derivatives that serve as oxygen donors, and neither molecular oxygen nor an external electron donor is required.	Oxygen	222-228	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
2917971-2	1989	Cytochrome P-450 is known to catalyze the following oxygen transfer reaction: RH + PhIO----ROH + PhI where RH represents a variety of hydroxylatable substrates and PhIO a variety of iodosobenzene derivatives that serve as oxygen donors, and neither molecular oxygen nor an external electron donor is required.	Oxygen	222-228	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
2564395-4	1989	VIP also stimulated oxygen consumption of the cells, an effect accounted for by the stimulation of the oxidation of both exogenous added palmitate (0.12 mM) and endogenous fatty acids produced by lipolysis.	Oxygen	20-26	vasoactive intestinal peptide	Rattus norvegicus	0-3
2646944-5	1989	There was a positive correlation before training between maximum O2 uptake (Vo2 max) and total body glucose disposal rate (M) at the 40 mU.m-2.min-1 insulin infusion (r = 0.69, P less than 0.02).	Oxygen	65-67	insulin	Homo sapiens	149-156
2521816-7	1989	In contrast, long-term ACE inhibition further improved exercise cardiac output and increased leg blood flow (from 2.3 to 2.9 l/min, p less than 0.05), leg oxygen consumption (from 277 to 403 ml/min, p less than 0.05), and systemic oxygen uptake (from 1,133 to 1,453 ml/min, p less than 0.05), whereas these variables remained unchanged with placebo treatment (p less than 0.02 between groups).	Oxygen	155-161	angiotensin I converting enzyme	Homo sapiens	23-26
2521816-7	1989	In contrast, long-term ACE inhibition further improved exercise cardiac output and increased leg blood flow (from 2.3 to 2.9 l/min, p less than 0.05), leg oxygen consumption (from 277 to 403 ml/min, p less than 0.05), and systemic oxygen uptake (from 1,133 to 1,453 ml/min, p less than 0.05), whereas these variables remained unchanged with placebo treatment (p less than 0.02 between groups).	Oxygen	231-237	angiotensin I converting enzyme	Homo sapiens	23-26
2521816-8	1989	Moreover, a moderate but significant increase in femoral oxygen extraction occurred after long-term therapy (ACE inhibitor: from 76% to 83%, p less than 0.05; placebo: from 75% to 74%, NS; p less than 0.01 between groups).	Oxygen	57-63	angiotensin I converting enzyme	Homo sapiens	109-112
2521816-10	1989	The long-term effects of ACE inhibition are, in part, probably related to peripheral (vascular) mechanisms, for example, by reversing the inability of peripheral vessels to dilate and by improving oxygen utilization.	Oxygen	197-203	angiotensin I converting enzyme	Homo sapiens	25-28
2539325-4	1989	In vitro treatment with recombinant interferon-gamma (rIFN-gamma) caused an enhancement of the capability of AM of inactive sarcoid patients to produce O2- in response to PMA.	Oxygen	152-154	interferon gamma	Homo sapiens	36-52
2494147-10	1989	It is concluded that active oxygen species, in particular hydroxyl radicals, may be generated during thrombin stimulation of platelets and cause injury to the endothelial cells.	Oxygen	28-34	coagulation factor II, thrombin	Homo sapiens	101-109
2551812-1	1989	Myeloperoxidase (MPO), present in the azurophilic granules of human polymorphonuclear neutrophils, is important in the oxygen-dependent microbicidal activity of neutrophils.	Oxygen	119-125	myeloperoxidase	Homo sapiens	0-15
2551812-1	1989	Myeloperoxidase (MPO), present in the azurophilic granules of human polymorphonuclear neutrophils, is important in the oxygen-dependent microbicidal activity of neutrophils.	Oxygen	119-125	myeloperoxidase	Homo sapiens	17-20
2492517-2	1989	Noradrenaline and the microsomal cytochrome P-450-dependent monooxygenase system were used to generate reduced oxygen species.	Oxygen	64-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
2507777-6	1989	Concomitantly, maintenance of eucapnia reduced the increase in heart rate (HR) and fall in arterial pressure (ABP), the effects being significant at Fi,O2 0.08 and/or 0.06.	Oxygen	152-154	glutamate receptor interacting protein 2	Rattus norvegicus	110-113
2733245-2	1989	In order to examine if oxygen free radical scavenger superoxide dismutase (SOD) in human plasma prevent reperfusion injury with successful thrombolysis and limit infarct size, we studied the relationship between infarct size and plasma SOD activity in 25 patients received thrombolytic therapy in antero-septal acute myocardial infarction.	Oxygen	23-29	superoxide dismutase 1	Homo sapiens	53-73
2733245-2	1989	In order to examine if oxygen free radical scavenger superoxide dismutase (SOD) in human plasma prevent reperfusion injury with successful thrombolysis and limit infarct size, we studied the relationship between infarct size and plasma SOD activity in 25 patients received thrombolytic therapy in antero-septal acute myocardial infarction.	Oxygen	23-29	superoxide dismutase 1	Homo sapiens	75-78
2730221-3	1989	min and n = 450 and 800 min-1 were respectively the lower and the upper levels of the optimal conditions by oxygen mass transfer during amphotericin B biosynthesis.	Oxygen	108-114	CD59 molecule (CD59 blood group)	Homo sapiens	24-29
2919680-8	1989	In the presence of angiotensin II (5 nM), a hormone that increases intracellular calcium, glucagon increased O2 uptake by nearly 100 mumol.g-1.h-1 at normal flow rates.	Oxygen	109-111	angiotensinogen	Rattus norvegicus	19-33
2730221-8	1989	min and n = less than 450 min-1) it was induced by insufficient supply of oxygen to the culture.	Oxygen	74-80	CD59 molecule (CD59 blood group)	Homo sapiens	26-31
2706089-0	1989	Modification of partial pressure of oxygen (P50) in mammalian red blood cells by incorporation of an allosteric effector of hemoglobin.	Oxygen	36-42	nuclear factor kappa B subunit 1	Homo sapiens	44-47
2537798-2	1989	There was a similarity in the dependency on extracellular Ca2+ for fluoride- and for FMLP-stimulated O2- generation and degranulation.	Oxygen	101-103	formyl peptide receptor 1	Homo sapiens	85-89
2923770-2	1989	No desaturation occurred in six patients given oxygen 2 litre min-1 via a nasal catheter during similar procedures.	Oxygen	47-53	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
2494137-0	1989	Interferon gamma-treated human macrophages display enhanced cytolysis and generation of reactive oxygen metabolites but reduced ingestion upon Fc receptor triggering.	Oxygen	97-103	interferon gamma	Homo sapiens	0-16
2663083-4	1989	Besides, some enzymes catalyzing the interconversions of active oxygen species (catalase superoxide dismutase, cytochrome P-450) are also inactivated in the course of catalysis under the oxidative action of active oxygen species.	Oxygen	64-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-127
2663083-4	1989	Besides, some enzymes catalyzing the interconversions of active oxygen species (catalase superoxide dismutase, cytochrome P-450) are also inactivated in the course of catalysis under the oxidative action of active oxygen species.	Oxygen	214-220	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-127
2782193-2	1989	Thus, a decrease in the proliferative fraction during monolayer growth of EMT6 cells is associated with a decrease in the oxygen consumption rate both per cell and per cellular volume.	Oxygen	122-128	IL2 inducible T cell kinase	Mus musculus	74-77
2496078-4	1989	Furthermore, prior contractions directed glucose uptake toward glycogen synthesis and increased insulin effects on thigh O2 consumption and at some insulin concentrations on potassium exchange.	Oxygen	121-123	insulin	Homo sapiens	96-103
2645309-1	1989	Sustained elevations of plasma glucose and insulin concentrations follow intense (80% maximum oxygen uptake) exercise performed in the postabsorptive state.	Oxygen	94-100	insulin	Homo sapiens	43-50
2535790-1	1989	Superoxide dismutase (superoxide: superoxide oxidoreductase, EC 1.15.1.1) (SOD) and ferricytochrome c are used to check the effects on luminol chemiluminescence induced by a xanthine or hypoxanthine/xanthine oxidase/oxygen system.	Oxygen	216-222	superoxide dismutase 1	Homo sapiens	75-78
2576989-7	1989	Somatostatin induced a dose-related decrease in intestinal blood flow, capillary surface area and intestinal oxygen consumption.	Oxygen	109-115	somatostatin	Canis lupus familiaris	0-12
2536792-2	1989	Using the fluorescent cyanine dye 3,3"-dipropylthiocarbocyanine (di-S-C3-(5)) as an optical probe of membrane potential we observed that 3-DZA at concentrations that inhibit FMLP-induced O2- production does not significantly alter FMLP-induced changes in transmembrane potential.	Oxygen	187-189	formyl peptide receptor 1	Homo sapiens	174-178
2462938-1	1989	Myeloperoxidase (MPO) is a critical component in the oxygen-dependent microbicidal activity of neutrophils.	Oxygen	53-59	myeloperoxidase	Homo sapiens	0-15
2783532-2	1989	Microinjection (icv) of human recombinant IL-1 beta (50 ng) caused acute (response within 60 min) increases in colonic temperature (1.8 degrees C), oxygen consumption (Vo2; 36%), white blood cell count (96%), and brown adipose tissue (BAT) activity (mitochondrial GDP binding, 129%) in conscious rats.	Oxygen	148-154	interleukin 1 beta	Homo sapiens	42-51
2783533-3	1989	IL-1 beta increased resting oxygen consumption by 25-49% in a dose-dependent manner.	Oxygen	28-34	interleukin 1 beta	Rattus norvegicus	0-9
2653209-0	1989	Oxygen sensing in the kidney and its relation to erythropoietin production.	Oxygen	0-6	erythropoietin	Homo sapiens	49-63
2735650-6	1989	Catalase, which converts H2O2 to H2O, had no effect by itself on cells growing at 20% O2, but it eliminated the superoxide dismutase and glucose oxidase enhancing effects.	Oxygen	27-29	catalase	Homo sapiens	0-8
2735650-7	1989	Catalase decreased colony formation of cells grown at 5% O2.	Oxygen	57-59	catalase	Homo sapiens	0-8
2735650-8	1989	Removal of adherent cells ablated the growth-enhancing effects noted at lowered (5%) O2 tension and also the superoxide dismutase and catalase effects at 20% or 5% O2.	Oxygen	164-166	catalase	Homo sapiens	134-142
2462938-1	1989	Myeloperoxidase (MPO) is a critical component in the oxygen-dependent microbicidal activity of neutrophils.	Oxygen	53-59	myeloperoxidase	Homo sapiens	17-20
2690907-9	1989	These effects of ACE inhibitors have largely been attributed to the reduction in myocardial O2-demand and increase in myocardial blood flow associated with blunting of angiotensin II formation.	Oxygen	92-94	angiotensin I converting enzyme	Homo sapiens	17-20
2757922-13	1989	MLS spheroids may be particularly useful in studies of therapeutic consequences of partial radiobiological hypoxia since complete hypoxia and different levels of partial hypoxia can be studied separately by varying spheroid size and the oxygen tension in the culture medium.	Oxygen	237-243	holocytochrome c synthase	Homo sapiens	0-3
2690907-12	1989	In fact, sulphydryl (-SH) containing ACE inhibitors such as captopril appear to act as scavengers of oxygen-derived free radical species thought to be important in the pathogenesis of both postischaemic contractile dysfunction and ischaemia/reperfusion induced myocyte necrosis.	Oxygen	101-107	angiotensin I converting enzyme	Homo sapiens	37-40
2519233-2	1989	A simplified model for cytochrome P-450 has been used by substituting the proposed biologically active ferric-oxene state of cytochrome P-450 by a singlet oxygen atom.	Oxygen	155-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-39
2557982-0	1989	On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase.	Oxygen	95-101	NAD(P)H quinone dehydrogenase 1	Homo sapiens	114-127
2535977-2	1989	Secretion products of thrombin-stimulated platelets as well as ATP, ATP gamma S, or ADP enhanced O2- responses of fMLP-stimulated neutrophils, although these nucleotides did not, by themselves, initiate an O2- response.	Oxygen	97-99	coagulation factor II	Rattus norvegicus	22-30
2557982-0	1989	On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase.	Oxygen	95-101	superoxide dismutase 1	Homo sapiens	132-152
2535977-2	1989	Secretion products of thrombin-stimulated platelets as well as ATP, ATP gamma S, or ADP enhanced O2- responses of fMLP-stimulated neutrophils, although these nucleotides did not, by themselves, initiate an O2- response.	Oxygen	206-208	coagulation factor II	Rattus norvegicus	22-30
2673851-2	1989	Generally, superoxide dismutase (SOD), which scavenges oxygen radicals or inhibits lipid peroxidation, is adapted to be induced (increased) under oxygen toxicity.	Oxygen	55-61	superoxide dismutase 1	Homo sapiens	11-31
2684534-0	1989	Preglomerular cortical oxygen diffusion shunt: a prerequisite for effective erythropoietin regulation?	Oxygen	23-29	erythropoietin	Homo sapiens	76-90
2673851-2	1989	Generally, superoxide dismutase (SOD), which scavenges oxygen radicals or inhibits lipid peroxidation, is adapted to be induced (increased) under oxygen toxicity.	Oxygen	55-61	superoxide dismutase 1	Homo sapiens	33-36
2707399-4	1989	The results show that: 1) there are no significant clinical and functional differences between groups A and B at the onset of and throughout the study; 2) in group B the daily use of oxygen therapy is significantly longer than in group A (17 +/- 3.5 h.day-1 vs 14 +/- 3 h.day-1, p less than 0.01) without any difference between groups B1 and B2; 3) outdoor walking activities are different between groups A and B, at least in those patients using oxygen more than 18 h.day-1.	Oxygen	183-189	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	335-347
2924759-5	1989	During walking on the treadmill, the means for oxygen consumption were 0.79 +/- 0.05, 0.81 +/- 0.06 and 0.83 +/- 0.04 l min-1 (NS) and in snow 2.24 +/- 0.18, 2.34 +/- 0.17 and 2.34 +/- 0.19 l min-1 (p less than 0.01) with the WJB, RB and RSB, respectively.	Oxygen	47-53	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
2550333-5	1989	Activity of NADPH-cytochrome P450 reductase was decreased at the elevated concentrations of O2.	Oxygen	92-94	cytochrome p450 oxidoreductase	Homo sapiens	12-43
2788629-2	1989	IL-1 beta also stimulated resting oxygen consumption (VO2) by 38 percent, in vitro thermogenic activity (mitochondrial GDP binding) of brown adipose tissue (BAT) by almost two-fold, and blood flow to brown fat (assessed from the distribution of radiolabelled microspheres) by nine-fold in lean animals.	Oxygen	34-40	interleukin 1 beta	Rattus norvegicus	0-9
2643542-3	1989	Release of oxidants during pseudosubstrate interaction with cytochrome P450s may be responsible for loss of enzymatic activity observed; enzyme activity can be protected by cytochrome P450 inhibitors, antioxidants, and lowered oxygen concentration.	Oxygen	227-233	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	60-75
2684801-3	1989	We have used genetics and E. coli to investigate the role and regulation of superoxide dismutase (SOD) and its relationship with the other constituents of the oxygen toxicity defence system.	Oxygen	159-165	superoxide dismutase 1	Homo sapiens	98-101
2684801-5	1989	The conditional oxygen sensitivity of these mutants, together with their increased mutation rate, demonstrated the essential biological role of SOD.	Oxygen	16-22	superoxide dismutase 1	Homo sapiens	144-147
2484707-4	1989	In rings denuded of endothelium, the relaxations evoked by SIN-1 were not affected by NG-monomethyl-L-arginine (L-NMMA, which inhibits the production of endothelium-derived relaxing factor), or by superoxide dismutase and catalase (scavengers of oxygen-derived free radicals), or by L-NMMA plus superoxide dismutase and catalase.	Oxygen	246-252	MAPK associated protein 1	Homo sapiens	59-64
2484707-7	1989	Therefore, the inhibitory interaction between SIN-1 and the endothelium may result from an endothelium-dependent production of oxygen-derived free radicals that may inactivate the nitric oxide generated by SIN-1, and from an inhibitory interaction between SIN-1 and endothelium-derived relaxing factor, released under basal conditions.	Oxygen	127-133	MAPK associated protein 1	Homo sapiens	46-51
2484692-12	1989	In accordance with an autocatalytic process, O2- further enhances sydnonimine decomposition, since in the presence of superoxide dismutase (SOD) the rate of SIN-1C and NO2-/NO3- formation from SIN-1A was reduced, whereas the rate of NO liberation seemingly increased.	Oxygen	45-47	superoxide dismutase 1	Homo sapiens	118-138
2484692-12	1989	In accordance with an autocatalytic process, O2- further enhances sydnonimine decomposition, since in the presence of superoxide dismutase (SOD) the rate of SIN-1C and NO2-/NO3- formation from SIN-1A was reduced, whereas the rate of NO liberation seemingly increased.	Oxygen	45-47	superoxide dismutase 1	Homo sapiens	140-143
2484692-14	1989	At the level of guanylate cyclase, the presence of SOD induced a leftward shift of the concentration-response curve to SIN-1, in agreement with an enhancement of efficacy of NO by blocking the NO-scavenging effect of O2-.	Oxygen	217-219	superoxide dismutase 1	Homo sapiens	51-54
2540265-8	1989	Experiments in vitro with .OH-scavengers (dimethylsulfoxide, ethanol) and with the enzyme, catalase, confirmed both the presence of .OH and its dependence upon generated hydrogen peroxide during the oxidation of ferrous salt by molecular oxygen.	Oxygen	238-244	catalase	Rattus norvegicus	91-99
2484692-14	1989	At the level of guanylate cyclase, the presence of SOD induced a leftward shift of the concentration-response curve to SIN-1, in agreement with an enhancement of efficacy of NO by blocking the NO-scavenging effect of O2-.	Oxygen	217-219	MAPK associated protein 1	Homo sapiens	119-124
2534128-0	1989	Release of atrial natriuretic factor with increasing absolute atmospheres of pressure in a hyperbaric chamber and reversal with oxygen therapy.	Oxygen	128-134	natriuretic peptide A	Homo sapiens	11-36
2534128-5	1989	With the addition of 100% oxygen while at depths of 33 and 66 feet, the concentration of ANF immediately decreased to its pre-dive concentration and remained there with further decompression to surface air and removal of oxygen supplementation.	Oxygen	26-32	natriuretic peptide A	Homo sapiens	89-92
2534128-5	1989	With the addition of 100% oxygen while at depths of 33 and 66 feet, the concentration of ANF immediately decreased to its pre-dive concentration and remained there with further decompression to surface air and removal of oxygen supplementation.	Oxygen	221-227	natriuretic peptide A	Homo sapiens	89-92
2708811-1	1989	Thromboxane synthase is a cytochrome P-450-like enzyme requiring an iron-centered oxygen attack of the prostaglandin endoperoxide substrate (PGH2) for subsequent thromboxane A2 (TxA2) formation.	Oxygen	82-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	26-42
3275328-7	1988	Reduced oxygen pressure did not affect staphylococcal growth, but resulted in lower enterotoxin levels after 48 h incubation.	Oxygen	8-14	Enterotoxin	Staphylococcus aureus	84-95
2915780-6	1989	The minimal time necessary for a hypoxic signal to induce EPO formation was found to be 30 min, including wash out of oxygen stores, activation of the EPO gene and equilibration of the EPO distribution space.	Oxygen	118-124	erythropoietin	Homo sapiens	58-61
2915780-7	1989	About 1.5 h after the onset of hypoxia, EPO mRNA was found to accumulate in the kidney, thus pointing toward the possibility of an oxygen-regulated transcription or oxygen-dependent regulation of the stability of EPO mRNA.	Oxygen	131-137	erythropoietin	Homo sapiens	40-43
2915780-7	1989	About 1.5 h after the onset of hypoxia, EPO mRNA was found to accumulate in the kidney, thus pointing toward the possibility of an oxygen-regulated transcription or oxygen-dependent regulation of the stability of EPO mRNA.	Oxygen	165-171	erythropoietin	Homo sapiens	40-43
2915780-7	1989	About 1.5 h after the onset of hypoxia, EPO mRNA was found to accumulate in the kidney, thus pointing toward the possibility of an oxygen-regulated transcription or oxygen-dependent regulation of the stability of EPO mRNA.	Oxygen	165-171	erythropoietin	Homo sapiens	213-216
2633329-9	1989	One year after surgery the Harris hip score had increased from 35 to 85 points and maximal walking speed from 62 to 80 m min-1 Oxygen cost had decreased from 0.267 to 0.221 ml kg-1m-1.	Oxygen	127-133	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
2576881-7	1989	Utilizing a model metal-catalyzed oxidation system (ascorbate/iron/oxygen) studies on bacterial glutamine synthetase revealed several functional and structural changes.	Oxygen	67-73	glutamate-ammonia ligase	Homo sapiens	96-116
2629168-3	1989	It was unaffected by omission of Ca from the saline, but the muscle was protected at 7.8 degrees C. "High-O2" gassing (10 ml sec-1) also caused a characteristic, but different, damage with swollen sarcoplasmic reticulum and spacing of the myofibrils.	Oxygen	106-108	secretory blood group 1	Mus musculus	125-130
2849206-6	1988	The inhibition of Epo production at low partial pressures of oxygen by carbon monoxide provides evidence that a heme protein is integrally involved in the oxygen-sensing mechanism.	Oxygen	61-67	erythropoietin	Homo sapiens	18-21
2852003-3	1988	These minute amounts of reduced oxygen species are suggested to account for the initiation of myeloperoxidase-oxidase oxidation of thiols.	Oxygen	32-38	myeloperoxidase	Homo sapiens	94-109
2852003-5	1988	However, myeloperoxidase-mediated oxidation of thiols with concomitant O2 consumption can also occur with myeloperoxidase in its Compound II oxidation state.	Oxygen	71-73	myeloperoxidase	Homo sapiens	9-24
2852003-5	1988	However, myeloperoxidase-mediated oxidation of thiols with concomitant O2 consumption can also occur with myeloperoxidase in its Compound II oxidation state.	Oxygen	71-73	myeloperoxidase	Homo sapiens	106-121
2848580-1	1988	O2- generation in mitochondrial electron transport systems, especially the NADPH-coenzyme Q10 oxidoreductase system, was examined using a model system, NADPH-coenzyme Q1-NADPH-dependent cytochrome P-450 reductase.	Oxygen	0-2	cytochrome p450 oxidoreductase	Homo sapiens	152-212
2849206-6	1988	The inhibition of Epo production at low partial pressures of oxygen by carbon monoxide provides evidence that a heme protein is integrally involved in the oxygen-sensing mechanism.	Oxygen	155-161	erythropoietin	Homo sapiens	18-21
2849206-0	1988	Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.	Oxygen	57-63	erythropoietin	Homo sapiens	18-32
3215863-2	1988	In the isolated perfused lung of the normal and O2-exposed rat, change in pre- and postcapillary resistance was determined in response to challenge with angiotensin II (ANG II; 5, 25, and 50 micrograms) or histamine (0.5 and 1.0 microgram).	Oxygen	48-50	angiotensinogen	Rattus norvegicus	153-167
3215871-6	1988	Mean values for rectal temperature (rate of increase) were 0.022 +/- 0.009 (SD) degrees C.min-1 for liquid O2 and 0.036 +/- 0.015 degrees C.min-1 for compressed O2 (P less than 0.005, 2-sided paired t test).	Oxygen	107-109	CD59 molecule (CD59 blood group)	Homo sapiens	90-95
3215871-6	1988	Mean values for rectal temperature (rate of increase) were 0.022 +/- 0.009 (SD) degrees C.min-1 for liquid O2 and 0.036 +/- 0.015 degrees C.min-1 for compressed O2 (P less than 0.005, 2-sided paired t test).	Oxygen	161-163	CD59 molecule (CD59 blood group)	Homo sapiens	140-145
3215871-7	1988	Mean values for heart rate (rate of increase) were 2.64 +/- 0.74 (SD) min-2 for liquid O2 and 3.27 +/- 0.89 min-2 for compressed O2 (P less than 0.02, 2-sided paired t test).	Oxygen	129-131	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
3143109-2	1988	To investigate the interaction of NMT with fatty acyl CoA substrates, we have synthesized 10 oxygen- or sulfur-substituted fatty acid analogs.	Oxygen	93-99	N-myristoyltransferase 1	Homo sapiens	34-37
3246544-6	1988	Fetal oxygen uptake increased from 5.7 +/- 0.3 to 6.5 +/- 0.4 ml.min-1 kg-1 (P less than 0.005) during contractures.	Oxygen	6-12	CD59 molecule (CD59 blood group)	Homo sapiens	65-75
3238640-4	1988	Portable oxygen (41 min-1) carried by the patient increased the mean endurance walking time by 59% and the six minute walking distance by 17%.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	20-25
2855142-0	1988	[Active oxygen production in myeloperoxidase system].	Oxygen	8-14	myeloperoxidase	Homo sapiens	29-44
2855158-0	1988	[Scavenging of active oxygen by manganese catalase].	Oxygen	22-28	catalase	Homo sapiens	42-51
3182815-5	1988	2) Hepatocyte plasma membrane NADH:ferricyanide oxidoreductase activity and uptake of iron from transferrin are stimulated by low oxygen concentration and inhibited by iodoacetate.	Oxygen	130-136	transferrin	Rattus norvegicus	96-107
3205070-5	1988	Cultures maintained under lower oxygen tension had higher proliferation rate, smaller cell size, lower rate of proteoglycan synthesis, and lower content of keratan sulfate side chains in the proteoglycan.	Oxygen	32-38	versican	Gallus gallus	111-123
3205070-5	1988	Cultures maintained under lower oxygen tension had higher proliferation rate, smaller cell size, lower rate of proteoglycan synthesis, and lower content of keratan sulfate side chains in the proteoglycan.	Oxygen	32-38	versican	Gallus gallus	191-203
3205070-7	1988	It is suggested that the increased proliferation rate and the decrease in proteoglycan synthesis caused by low oxygen tension may be signalled by the higher [Ca2+]in in these cells.	Oxygen	111-117	versican	Gallus gallus	74-86
3238640-5	1988	The endurance time for cycling at a constant work load was increased by 51% with oxygen at a flow rate of 21 min-1, by 88% at 41 min-1, and by 80% at 61 min-1.	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
3231222-12	1988	Evidence for the generation of oxygen radicals by these cells includes inhibition of the response in the absence of oxygen or in the presence of superoxide dismutase, catalase, and mannitol, and dose-dependent reduction of acetylated cytochrome C. We conclude that free radical-mediated damage to the pulmonary endothelium significantly increases the metastasis of circulating tumor cells and we postulate that some cancer cells may directly facilitate their spread by generating free radicals.	Oxygen	31-37	catalase	Rattus norvegicus	167-175
3251282-0	1988	[Scavenging of active oxygen by heme catalase].	Oxygen	22-28	catalase	Homo sapiens	37-46
3242596-5	1988	However, penetration to truly buried tryptophans is less favorable than previously suggested; in five proteins studied, quenching efficiency by O2 is 20-1000 times lower than for NATA, and up to 10(5) lower for H2S and CS2.	Oxygen	144-146	chorionic somatomammotropin hormone 2	Homo sapiens	219-222
3191921-7	1988	The third binding site is a result of crystal packing effects: caesium is liganded by four oxygen atoms, provided by two rhodanese molecules and one sulphate ion.	Oxygen	91-97	thiosulfate sulfurtransferase	Bos taurus	121-130
3141381-0	1988	lac fusion analysis of the bet genes of Escherichia coli: regulation by osmolarity, temperature, oxygen, choline, and glycine betaine.	Oxygen	97-103	putative DNA recombination protein Bet	Escherichia coli	27-30
3248608-0	1988	[Effect of neurotensin on circulation and oxygen consumption of the intestines].	Oxygen	42-48	neurotensin	Homo sapiens	11-22
3227943-1	1988	Seven men performed one-legged isometric knee extension at 5% MVC for 1 h. Total body oxygen uptake amounted to 451 (420-471) ml min-1 and oxygen uptake over the contracting leg to 200 (172-216) ml min-1, with no changes occurring during the 1 h contraction.	Oxygen	86-92	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Oxygen	284-290	cytochrome c, somatic	Homo sapiens	15-27
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Oxygen	284-290	cytochrome c, somatic	Homo sapiens	145-157
2853215-7	1988	radical rapidly reacts with oxygen to give NAD+ and superoxide O2- anion radical which, in turn, reduces the second iron(III) cytochrome c molecule.	Oxygen	28-34	cytochrome c, somatic	Homo sapiens	126-138
3205607-8	1988	Disaturated phosphatidylcholine and SP-A content were significantly increased in alveolar surfactant material isolated from oxygen-treated rats.	Oxygen	124-130	surfactant protein A1	Rattus norvegicus	36-40
3205607-9	1988	SP-A content was also significantly increased in lung tissue from oxygen-treated rats.	Oxygen	66-72	surfactant protein A1	Rattus norvegicus	0-4
3205607-10	1988	The SP-A in the lavage of oxygen-treated rats appeared to be intact protein as no proteolytic fragments were detected and the SP-A migrated identically to that recovered from room air animals when analyzed by two-dimensional isoelectric focusing.	Oxygen	26-32	surfactant protein A1	Rattus norvegicus	4-8
3205607-10	1988	The SP-A in the lavage of oxygen-treated rats appeared to be intact protein as no proteolytic fragments were detected and the SP-A migrated identically to that recovered from room air animals when analyzed by two-dimensional isoelectric focusing.	Oxygen	26-32	surfactant protein A1	Rattus norvegicus	126-130
3262489-0	1988	Effects of interleukin-2 on oxygen delivery and consumption in patients with advanced malignancy.	Oxygen	28-34	interleukin 2	Homo sapiens	11-24
2853633-2	1988	The ability of serum proteins (albumin, immunoglobulin G) and protein antioxidants (ceruloplasmin, superoxide dismutase and transferrin) to react with O2-.	Oxygen	151-153	transferrin	Homo sapiens	124-135
3262489-3	1988	These results suggest that oxygen consumption may be dependent on oxygen delivery in patients on IL-2 therapy.	Oxygen	27-33	interleukin 2	Homo sapiens	97-101
3262489-3	1988	These results suggest that oxygen consumption may be dependent on oxygen delivery in patients on IL-2 therapy.	Oxygen	66-72	interleukin 2	Homo sapiens	97-101
3229124-0	1988	Superoxide dismutase activity and growth of retinal pigment epithelial cells are suppressed by 20% oxygen in vitro.	Oxygen	99-105	superoxide dismutase 1	Homo sapiens	0-20
3262489-4	1988	The presence of oxygen supply dependency may contribute to the multiple organ failure observed with IL-2 administration.	Oxygen	16-22	interleukin 2	Homo sapiens	100-104
3229124-4	1988	Inclusion of SOD and catalase in the media very significantly stimulated growth in 20% oxygen.	Oxygen	87-93	superoxide dismutase 1	Homo sapiens	13-16
3206382-3	1988	After allowance for confounding factors the asthmatic subjects had a lower maximum oxygen consumption (VO2 max) (by 199 ml min-1) than control subjects.	Oxygen	83-89	CD59 molecule (CD59 blood group)	Homo sapiens	123-128
3229124-4	1988	Inclusion of SOD and catalase in the media very significantly stimulated growth in 20% oxygen.	Oxygen	87-93	catalase	Homo sapiens	21-29
3229124-5	1988	The SOD activity of RPE cells was significantly related to ambient oxygen.	Oxygen	67-73	superoxide dismutase 1	Homo sapiens	4-7
3229124-6	1988	In first passage (P1) cells, SOD activity was 44% lower on day 7 than on day 1 of culture in 20% oxygen (p less than or equal to 0.05).	Oxygen	97-103	superoxide dismutase 1	Homo sapiens	29-32
3229124-7	1988	Transfer of cells growing in 20% oxygen to 5% oxygen arrested the decrease in SOD and resulted in significantly higher SOD levels.	Oxygen	33-39	superoxide dismutase 1	Homo sapiens	78-81
3229124-7	1988	Transfer of cells growing in 20% oxygen to 5% oxygen arrested the decrease in SOD and resulted in significantly higher SOD levels.	Oxygen	33-39	superoxide dismutase 1	Homo sapiens	119-122
3229124-7	1988	Transfer of cells growing in 20% oxygen to 5% oxygen arrested the decrease in SOD and resulted in significantly higher SOD levels.	Oxygen	46-52	superoxide dismutase 1	Homo sapiens	78-81
3229124-7	1988	Transfer of cells growing in 20% oxygen to 5% oxygen arrested the decrease in SOD and resulted in significantly higher SOD levels.	Oxygen	46-52	superoxide dismutase 1	Homo sapiens	119-122
3229124-8	1988	In fourth passage (P4) cells grown in 20% oxygen, SOD was 25% and 44% lower than cells in 10% and 5% oxygen, respectively.	Oxygen	42-48	superoxide dismutase 1	Homo sapiens	50-53
3229124-10	1988	A statistical model of SOD activity in RPE cells indicated significant negative correlations with both oxygen concentration and the cell number.	Oxygen	103-109	superoxide dismutase 1	Homo sapiens	23-26
24221924-6	1988	This is the first report of Lb in uninfected cells of any legume nodule; it raises the possibility that this important nodule-specific protein may participate in mediating oxygen flow to host plant organelles throughout the infected region of the nodule.	Oxygen	172-178	leghemoglobin A	Glycine max	28-30
2466914-3	1988	An increase in O2 consumption after f-MLP-stimulation was seen when PMN had been incubated 2-4 h with either 1000 IU/ml IFN-alpha or 100 IU/ml IFN-gamma, but this increase in O2 consumption was not observed with 1000 IU/ml IFN-beta.	Oxygen	15-17	interferon alpha 1	Homo sapiens	120-129
2466914-3	1988	An increase in O2 consumption after f-MLP-stimulation was seen when PMN had been incubated 2-4 h with either 1000 IU/ml IFN-alpha or 100 IU/ml IFN-gamma, but this increase in O2 consumption was not observed with 1000 IU/ml IFN-beta.	Oxygen	15-17	interferon gamma	Homo sapiens	143-152
2847035-3	1988	Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.	Oxygen	157-163	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	29-34
3265249-2	1988	The secreted lymphokine enhanced the oxygen-dependent metabolism of neutrophils.	Oxygen	37-43	interleukin 2	Homo sapiens	13-23
2843526-2	1988	The rate of cytochrome c2+ oxidation by O2 is shown to be affected by several factors: 1) pH, with optima at 5.65 and 6.0, 2) temperature between 0 and 29 degrees C, with E alpha = 13 kcal mol-1, 3) D2O exchange, with a reduction in rate of 50% or more at the pH optima, and 4) the addition of ethylene glycol or glycerol, which significantly lowers the rate.	Oxygen	40-42	cytochrome c, testis	Bos taurus	12-25
3052256-3	1988	This occurs by modulating colony stimulating factor and erythropoietin production in response to lactoferrin and oxygen tension respectively.	Oxygen	113-119	erythropoietin	Homo sapiens	56-70
2459200-2	1988	The neuropeptide substance P (SP), which has been suggested to mediate neurogenic inflammation, induces in human neutrophils the activation of the respiratory burst measured as O2 consumption and H2O2 production, and a cytochalasin B-dependent secretion of specific and azurophilic granules.	Oxygen	177-179	tachykinin precursor 1	Homo sapiens	17-28
2459200-2	1988	The neuropeptide substance P (SP), which has been suggested to mediate neurogenic inflammation, induces in human neutrophils the activation of the respiratory burst measured as O2 consumption and H2O2 production, and a cytochalasin B-dependent secretion of specific and azurophilic granules.	Oxygen	177-179	tachykinin precursor 1	Homo sapiens	30-32
2843056-7	1988	In this group, a significant increase in coronary blood flow with minimal change in myocardial oxygen could still be elicited by VIP injection after VIP infusion.	Oxygen	95-101	vasoactive intestinal peptide	Canis lupus familiaris	129-132
3046293-6	1988	Although acute angiotensin-converting enzyme inhibition usually neither exerts substantial improvement in exercise hemodynamics nor interferes with leg perfusion during exercise, skeletal muscle blood flow and oxygen uptake gradually increases with long-term angiotensin-converting enzyme therapy, leading to improved systemic oxygen consumption and exercise tolerance.	Oxygen	210-216	angiotensin I converting enzyme	Homo sapiens	259-288
3046293-6	1988	Although acute angiotensin-converting enzyme inhibition usually neither exerts substantial improvement in exercise hemodynamics nor interferes with leg perfusion during exercise, skeletal muscle blood flow and oxygen uptake gradually increases with long-term angiotensin-converting enzyme therapy, leading to improved systemic oxygen consumption and exercise tolerance.	Oxygen	327-333	angiotensin I converting enzyme	Homo sapiens	259-288
2841147-9	1988	Direct measurement of oxygen consumption in the presence of captopril showed marked enhancement with the addition of CuSO4 and a 48% reduction in the presence of added catalase.	Oxygen	22-28	catalase	Homo sapiens	168-176
2844672-6	1988	When the inhibition of O2- generation by the combined action of AF and GTS was compared with AF + gold sodium thiomalate (GTM), only GTS showed an activation on AF"s inhibition of the oxygen burst of human leukocytes.	Oxygen	23-25	GTS	Homo sapiens	64-74
3192277-0	1988	Culture medium oxygen tension affects fibronectin production in human adult and cord blood macrophages.	Oxygen	15-21	fibronectin 1	Homo sapiens	38-49
3192277-2	1988	Lowering oxygen tension did result in significant increases in fibronectin concentration in both adult and cord blood macrophage culture supernatants.	Oxygen	9-15	fibronectin 1	Homo sapiens	63-74
3192277-4	1988	These results indicate that human macrophages selectively regulate fibronectin production in response to changes in oxygen tension in vitro.	Oxygen	116-122	fibronectin 1	Homo sapiens	67-78
3221244-3	1988	Superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase provide the enzymatic defence against oxygen toxicity.	Oxygen	120-126	catalase	Homo sapiens	22-30
3135328-3	1988	Neutrophils exposed to influenza virus for 0.5 h at 37 degrees C showed depressed O2- generation and release of radiolabeled arachidonic acid upon stimulation with FMLP.	Oxygen	82-84	formyl peptide receptor 1	Homo sapiens	164-168
3396001-2	1988	We have tested this prediction by making use of an oxygen-resistant variant subline of Chinese hamster ovary cells (CHOr), which is characterized by increased levels of glutathione, copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase.	Oxygen	51-57	catalase	Homo sapiens	275-284
2844672-6	1988	When the inhibition of O2- generation by the combined action of AF and GTS was compared with AF + gold sodium thiomalate (GTM), only GTS showed an activation on AF"s inhibition of the oxygen burst of human leukocytes.	Oxygen	23-25	GTS	Homo sapiens	71-74
2844672-6	1988	When the inhibition of O2- generation by the combined action of AF and GTS was compared with AF + gold sodium thiomalate (GTM), only GTS showed an activation on AF"s inhibition of the oxygen burst of human leukocytes.	Oxygen	184-190	GTS	Homo sapiens	71-74
2844672-7	1988	The ligand thiosulfate in equimolar concentrations to GTS had a statistically significant (P less than 0.01) inhibitory effect on AF"s blockade of O2- generation during the first 5 min of the interaction with the PMNs; thiomalate had no effect.	Oxygen	147-149	GTS	Homo sapiens	54-57
3413080-2	1988	LR16 (1 mM) raises P50, the partial pressure of oxygen needed to achieve half-saturation with oxygen of a hemolysate of human hemoglobin, about 50 times more strongly than 1 mM 2,3-bisphosphoglycerate.	Oxygen	48-54	nuclear factor kappa B subunit 1	Homo sapiens	19-22
3173047-5	1988	Triathlon running, while performing identical control work output, elicited significant increases (P less than 0.05) in oxygen uptake (3.41 +/- 0.1 to 3.85 +/- 0.1 l.min-1), ventilation (91.3 +/- 3.3 to 104.2 +/- 2.8 l.min-1), heart rate (161 +/- 3.1 to 174 +/- 3.6 beats.min-1), arteriovenous oxygen difference (15.3 +/- 0.2 to 17.2 +/- 0.3 ml.100 ml-1) and rectal temperature (38.3 +/- 0.2 and 39.2 +/- 0.3 degrees C) with significantly lower (P less than 0.05) stroke volume (138 +/- 2.4 to 129 +/- 3.6 ml.min-1) and mean arterial pressure (102 +/- 11.2 to 89 +/- 5.5 mm Hg).	Oxygen	120-126	CD59 molecule (CD59 blood group)	Homo sapiens	166-171
3394615-5	1988	Aortic oxygen saturation higher than 80% was associated with a low erythropoietin titer and a hemoglobin level below that associated with hyperviscosity.	Oxygen	7-13	erythropoietin	Homo sapiens	67-81
3401235-0	1988	Effects of reactive oxygen metabolites on erythropoietin production in renal carcinoma cells.	Oxygen	20-26	erythropoietin	Homo sapiens	42-56
3401235-1	1988	The present studies were undertaken to determine the effects of reactive oxygen metabolites on erythropoietin (Ep) biosynthesis in Ep-producing renal carcinoma (RC) cells using a sensitive radioimmunoassay for Ep.	Oxygen	73-79	erythropoietin	Homo sapiens	95-109
3385211-0	1988	Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species.	Oxygen	102-108	C-reactive protein	Homo sapiens	62-80
3052576-5	1988	Incubation of 6 beta-hydroxyprogesterone with a reconstituted system in an atmosphere of 18O2 resulted in greater than 90% incorporation of 18O in the 16 alpha-position of 6 beta,16 alpha-dihydroxyprogesterone but no incorporation of 18O into 6-ketoprogesterone, even though the reaction was dependent upon enzyme and O2, and not inhibited by mannitol, catalase, or superoxide dismutase.	Oxygen	91-93	catalase	Rattus norvegicus	353-361
3393628-9	1988	The sensitizing effect of oxygen in the presence of MSH is reduced by t-butanol and may even be reversed to produce an apparently protective effect.	Oxygen	26-32	msh homeobox 2	Homo sapiens	52-55
3382287-8	1988	In vitro studies revealed that human immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a in a dose-dependent manner, although human albumin treated identically as human immunoglobulin did not produce these complements.	Oxygen	75-81	complement C5a receptor 1	Homo sapiens	114-117
2839167-4	1988	When O2 was included in the extract for 2 h, the ACE activity also increased to about twice the original activity.	Oxygen	5-7	angiotensin I converting enzyme	Rattus norvegicus	49-52
2968671-6	1988	Both naloxone and met-enkephalin increased neutrophil oxygen consumption in a dose-dependent fashion, whereas beta-endorphin impaired neutrophil oxygen consumption.	Oxygen	54-60	proopiomelanocortin	Homo sapiens	18-32
2968671-6	1988	Both naloxone and met-enkephalin increased neutrophil oxygen consumption in a dose-dependent fashion, whereas beta-endorphin impaired neutrophil oxygen consumption.	Oxygen	145-151	proopiomelanocortin	Homo sapiens	110-124
3167503-7	1988	Predicted mean gross values of oxygen consumption for the males were 42.8 +/- 5.7 ml.kg-1 min-1 and 42.8 +/- 6.9 ml.kg-1 min-1 for the Modern and Latin American sequences respectively.	Oxygen	31-37	CD59 molecule (CD59 blood group)	Homo sapiens	90-95
3377513-4	1988	Separate experiments with catalase showed that oxygen consumption could be equated with the formation of hydrogen peroxide.	Oxygen	47-53	catalase	Homo sapiens	26-34
3184250-4	1988	When the subject can no longer follow the pace, the last stage number announced is used to predict maximal oxygen uptake (VO2max) (Y, ml kg-1 min-1) from the speed (X, km h-1) corresponding to that stage (speed = 8 + 0.5 stage no.)	Oxygen	107-113	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
3167503-8	1988	Corresponding gross estimates of oxygen consumption for the females were 34.7 +/- 3.8 ml.kg-1 min-1 and 36.1 +/- 4.1 ml.kg-1 min-1.	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	94-108
3290588-10	1988	Complete functional recovery was achieved by the intracellular Sacks plus glucose storage solution and modified blood reperfusion with oxygen-derived free radical scavengers (high catalase).	Oxygen	135-141	catalase	Homo sapiens	180-188
3167503-8	1988	Corresponding gross estimates of oxygen consumption for the females were 34.7 +/- 3.8 ml.kg-1 min-1 and 36.1 +/- 4.1 ml.kg-1 min-1.	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
3167503-11	1988	A significant difference between males and females was observed for predicted gross and net values of oxygen consumption (in L.min-1 and ml.kg-1 min-1).	Oxygen	102-108	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
3167503-11	1988	A significant difference between males and females was observed for predicted gross and net values of oxygen consumption (in L.min-1 and ml.kg-1 min-1).	Oxygen	102-108	CD59 molecule (CD59 blood group)	Homo sapiens	145-150
3391643-3	1988	The percentage of cells with IL-2 and transferrin-receptors was reduced by the O2 exposure and, like the cell cycle transition, was protected by 2-ME against oxidative injury.	Oxygen	79-81	interleukin 2	Homo sapiens	29-33
2968330-11	1988	These results support the hypothesis that the decrease in Pi T1 measured with oxygen breathing is a measure of tumor oxygen tension and metabolic rate, and suggests that T1 measurement may indirectly predict tumor growth rate and DNA synthesis.	Oxygen	78-84	POU domain, class 1, transcription factor 1	Mus musculus	58-63
2968330-11	1988	These results support the hypothesis that the decrease in Pi T1 measured with oxygen breathing is a measure of tumor oxygen tension and metabolic rate, and suggests that T1 measurement may indirectly predict tumor growth rate and DNA synthesis.	Oxygen	117-123	POU domain, class 1, transcription factor 1	Mus musculus	58-63
3391643-4	1988	By contrast, IL-2 recovery in the supernatants of O2-exposed PHA-stimulated PBMC was enhanced.	Oxygen	50-52	interleukin 2	Homo sapiens	13-17
3391643-6	1988	On the other hand, IL-2 recovery in the supernatants of O2-treated PBMC was always enhanced compared to the IL-2 control recovery after DNA synthesis was blocked in G1/S by mitomycin c, and the G0/G1 transition was protected by 2-ME.	Oxygen	56-58	interleukin 2	Homo sapiens	19-23
3391643-11	1988	By contrast, exposure to O2 induced increases in the production of both IL-1 and IL-2 that may not be related to alterations in the thiol status of the cell.	Oxygen	25-27	interleukin 2	Homo sapiens	81-85
3377780-6	1988	These results indicate that some isoenzymes of cytochrome P-450 are more effective than others in metabolizing CCl4 when oxygen is present.	Oxygen	121-127	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	47-63
3293731-4	1988	Studies of subjects from various countries report aerobic power generally between 40 and 50 mL O2/kg.min-1, with a mean around 45 mL.	Oxygen	95-97	CD59 molecule (CD59 blood group)	Homo sapiens	101-106
3377780-0	1988	Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.	Oxygen	33-39	C-C motif chemokine ligand 4	Rattus norvegicus	14-18
3377780-6	1988	These results indicate that some isoenzymes of cytochrome P-450 are more effective than others in metabolizing CCl4 when oxygen is present.	Oxygen	121-127	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
3377780-0	1988	Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.	Oxygen	33-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	69-85
3377780-1	1988	Oxygen inhibition of CCl4 metabolism by different isoenzymes of cytochrome P-450 was assessed by studying liver microsomes isolated from control rats and rats treated with phenobarbital or isoniazid.	Oxygen	0-6	C-C motif chemokine ligand 4	Rattus norvegicus	21-25
3143279-8	1988	or H2O2 (derived from O2-) contribute to the well-documented increase in lung permeability in RPE because dimethylthiourea, dimethylthiourea plus catalase, or catalase alone inhibited the edema to various degrees.	Oxygen	5-7	catalase	Oryctolagus cuniculus	146-154
3377780-1	1988	Oxygen inhibition of CCl4 metabolism by different isoenzymes of cytochrome P-450 was assessed by studying liver microsomes isolated from control rats and rats treated with phenobarbital or isoniazid.	Oxygen	0-6	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-80
3129432-8	1988	Thus, PEG conjugation to superoxide dismutase and catalase enhances cell association of these enzymes in a manner which increases cellular enzyme activities and provides prolonged protection from partially reduced oxygen species.	Oxygen	214-220	catalase	Homo sapiens	50-58
3394482-8	1988	The highest concentration of thiopentone depressed both oxygen uptake and volume/aggregation responses in FMLP-stimulated PMN.	Oxygen	56-62	formyl peptide receptor 1	Homo sapiens	106-110
3143279-8	1988	or H2O2 (derived from O2-) contribute to the well-documented increase in lung permeability in RPE because dimethylthiourea, dimethylthiourea plus catalase, or catalase alone inhibited the edema to various degrees.	Oxygen	5-7	catalase	Oryctolagus cuniculus	159-167
2843167-0	1988	Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen.	Oxygen	125-131	superoxide dismutase 1	Homo sapiens	0-20
3364583-6	1988	Myocardial O2 consumption was significantly reduced during hypoxia in the presence of adenosine deaminase.	Oxygen	11-13	adenosine deaminase	Cavia porcellus	86-105
2843167-7	1988	Secondly, the superoxide anions formed in the first step are dismuted by SOD to generate hydrogen peroxide and molecular oxygen, and hence the equilibrium in the first step is displaced in favour of the formation of superoxide anions.	Oxygen	121-127	superoxide dismutase 1	Homo sapiens	73-76
2844308-1	1988	The ability of major serum proteins (albumin, immunoglobulin G) and free radical scavenger proteins (ceruloplasmin, superoxide dismutase, transferrin) to interact with O2-.	Oxygen	168-170	transferrin	Homo sapiens	138-149
3262376-0	1988	[Rhodopsin photo-oxidation: oxygen consumption and spectrum of activity].	Oxygen	28-34	rhodopsin	Homo sapiens	1-10
3262376-4	1988	Oxygen consumption in photooxidation of rhodopsin SH-groups and lipids are determined.	Oxygen	0-6	rhodopsin	Homo sapiens	40-49
3415646-3	1988	The oxidation of aniline or aminopyrine and the cytochrome P-450/oxygen-radical-independent oxidation of ethanol also displayed a biphasic response to the concentration of O2, reaching a maximum at 20% O2, which correlates with the dithionite-reducible CO-binding spectra of cytochrome P-450.	Oxygen	172-174	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
3415646-3	1988	The oxidation of aniline or aminopyrine and the cytochrome P-450/oxygen-radical-independent oxidation of ethanol also displayed a biphasic response to the concentration of O2, reaching a maximum at 20% O2, which correlates with the dithionite-reducible CO-binding spectra of cytochrome P-450.	Oxygen	172-174	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	275-291
3415646-3	1988	The oxidation of aniline or aminopyrine and the cytochrome P-450/oxygen-radical-independent oxidation of ethanol also displayed a biphasic response to the concentration of O2, reaching a maximum at 20% O2, which correlates with the dithionite-reducible CO-binding spectra of cytochrome P-450.	Oxygen	202-204	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
3415646-3	1988	The oxidation of aniline or aminopyrine and the cytochrome P-450/oxygen-radical-independent oxidation of ethanol also displayed a biphasic response to the concentration of O2, reaching a maximum at 20% O2, which correlates with the dithionite-reducible CO-binding spectra of cytochrome P-450.	Oxygen	202-204	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	275-291
2449832-6	1988	When a lower dose of bleomycin (50 micrograms) or when a 30-h exposure to 100% oxygen were used, both ACE and protein increased but enzyme specific activity did not change.	Oxygen	79-85	angiotensin I converting enzyme	Rattus norvegicus	102-105
3072554-4	1988	Peroxidation of lipids is a major consequence of exposure to these species and the cell possesses various enzymes, including superoxide dismutase and catalase, as well as cellular antioxidants which are able to scavenge oxygen free radicals and repair peroxidized lipids.	Oxygen	220-226	catalase	Homo sapiens	150-158
3360137-5	1988	In contrast to copper-quinoprotein amine oxidases (EC 1.4.3.6), hydrazone formation in DBH did not require saturation of the mixture with O2.	Oxygen	138-140	dopamine beta-hydroxylase	Bos taurus	87-90
3411608-4	1988	These spectroscopic data parallel the conclusions drawn from the results of ligand combination and dissociation kinetics; stopped-flow experiments indicate that carbon monoxide and oxygen bind to mini-myoglobin with rates almost identical with those of myoglobin itself.	Oxygen	181-187	myoglobin	Equus caballus	201-210
3411608-5	1988	The significance of mini-myoglobin as a model of an oxygen-carrying protein, with some of the expected functional characteristics of an ancestor haemoprotein, is discussed, with reference to the mosaic structure of the myoglobin gene and the role of different exons in the evolution of proteins.	Oxygen	52-58	myoglobin	Equus caballus	25-34
2837317-0	1988	Cytochrome C, a potent oxygen free radical scavenger against the calcium paradox injury in the myocardium.	Oxygen	23-29	cytochrome c, somatic	Homo sapiens	0-12
2837317-10	1988	The data provide strong evidence that cytochrome C is a potent protective agent against the calcium paradox injury that may be caused by oxygen-derived radicals.	Oxygen	137-143	cytochrome c, somatic	Homo sapiens	38-50
2831977-7	1988	During illumination of reaction center membranes supplemented with cytochrome c and a ubiquinone pool, there is a small but significant steady-state current which is considered to be caused by the re-oxidation of photoreduced quinone by molecular oxygen.	Oxygen	247-253	cytochrome c, somatic	Homo sapiens	67-79
3125740-5	1988	These results show that the IFN-gamma treatment in vitro could strengthen PM luminal diameter phagocytosis, oxygen metabolite generation, and bacterial killing in CAPD patients with HPI, and suggest that IFN-gamma may be considered a possible therapy in vivo for these patients.	Oxygen	108-114	interferon gamma	Homo sapiens	28-37
3348718-6	1988	The average (+/- standard error) maximal oxygen consumption (VO2max) for all players was 53.4 +/- 0.8 ml x kg-1 x min-1.	Oxygen	41-47	CD59 molecule (CD59 blood group)	Homo sapiens	114-119
2900738-8	1988	The fact that the reconstituted system, which contains NADPH-cytochrome P-450 reductase, is oxygen insensitive suggests that there is an obligatory electron flow through cytochrome P-450 to DAB, bypassing the oxygen-sensitive step.	Oxygen	92-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	61-77
2900738-8	1988	The fact that the reconstituted system, which contains NADPH-cytochrome P-450 reductase, is oxygen insensitive suggests that there is an obligatory electron flow through cytochrome P-450 to DAB, bypassing the oxygen-sensitive step.	Oxygen	209-215	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	61-77
3141579-0	1988	PSK, a polysaccharide from Coriolus vesicolor, enhances oxygen metabolism of murine peritoneal macrophages and the host resistance to listerial infection.	Oxygen	56-62	TAO kinase 2	Mus musculus	0-3
3141579-5	1988	The enhanced O2(-)-producing ability due to PSK injection persisted much longer than the enhanced CL, indicating a discrepancy in regulation of generation of active oxygen species such as O2-, H2O2, OH, and 1O2.	Oxygen	13-15	TAO kinase 2	Mus musculus	44-47
3141579-9	1988	Therefore, PSK is thought to augment the host resistance to certain intracellular parasites including L. monocytogenes at least to some extent by enhancing oxygen metabolism of the host M phi.	Oxygen	156-162	TAO kinase 2	Mus musculus	11-14
2833658-5	1988	To demonstrate that oxygen metabolites were responsible for the toxicity, we assessed the protective effects of catalase and superoxide dismutase, scavengers of hydrogen peroxide and the superoxide anion, respectively.	Oxygen	20-26	catalase	Rattus norvegicus	112-120
2833658-10	1988	Both catalase and superoxide dismutase protected the [3H]palmitate incorporation of oxygen metabolite-exposed type II cells.	Oxygen	84-90	catalase	Rattus norvegicus	5-13
3399365-8	1988	O2-consumption (l.min-1) and heart rates (beats.min-1) were similar during outdoor and indoor bicycling, averaging 2.38 +/- 0.018 (SE) and 2.26 +/- 0.07, 141 +/- 7 and 147 +/- 8, respectively.	Oxygen	0-2	CD59 molecule (CD59 blood group)	Homo sapiens	18-23
24221416-6	1988	Catalase, cyanide and ascorbate, a superoxide scavenger, all individually inhibited the SHAM-stimulated O2 uptake.	Oxygen	104-106	catalase	Homo sapiens	0-8
3127945-0	1988	Detection of CCl4-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing.	Oxygen	65-71	C-C motif chemokine ligand 4	Rattus norvegicus	13-17
2830813-0	1988	Protection of rat from oxygen toxicity by inducers of cytochrome P-450 system.	Oxygen	23-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
2830813-8	1988	In contrast, in control rats, the activities of the antioxidant enzymes were not increased, and both the quantity and the peroxidase activity of cytochrome P-450 were significantly decreased by O2 exposure.	Oxygen	194-196	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	145-161
2830813-9	1988	We conclude that in the rat, pretreatment by inducers of pulmonary cytochrome P-450 results in marked protection against O2 toxicity and an increase of antioxidant enzyme response to hyperoxia.	Oxygen	121-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
3127205-2	1988	The reaction required molecular oxygen and NADPH, and was significantly inhibited by carbon monoxide, suggesting that a cytochrome P-450 is involved.	Oxygen	32-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-136
3127205-9	1988	These observations provide direct evidence that the oxygen-activating component of the LTB4 omega-hydroxylase system is a cytochrome P-450.	Oxygen	52-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-109
3127205-9	1988	These observations provide direct evidence that the oxygen-activating component of the LTB4 omega-hydroxylase system is a cytochrome P-450.	Oxygen	52-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	122-138
2832723-1	1988	CCl4 has been shown previously to be metabolized to the trichloromethyl radical (.CCl3) and to a novel oxygen-containing carbon dioxide anion radical (.CO2-) in the perfused rat liver and in vivo.	Oxygen	103-109	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
2832315-0	1988	Interferon-gamma activates human neutrophil oxygen metabolism and exocytosis.	Oxygen	44-50	interferon gamma	Homo sapiens	0-16
2832316-2	1988	The lymphokine inhibited the locomotion of neutrophils and augmented the neutrophil oxygen-dependent respiratory burst in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and phorbol myristate acetate (PMA), as measured by their capacity to produce chemiluminescence, H2O2 and superoxide.	Oxygen	84-90	formyl peptide receptor 1	Homo sapiens	181-185
3284873-4	1988	Studies were performed without prior exercise, as well as 2 and 48 h after 60 min of bicycle exercise at 150 W. We found 1) a progressive increase in insulin concentrations reaching 1,092 +/- 135 microU/ml with increasing glucose levels, 2) linear relationships between glucose concentrations and concentrations of C-peptide (r = 0.931 +/- 0.008) and proinsulin (r = 0.952 +/- 0.009),3) increased glucose oxidation with increasing glucose uptake, 4) increased plasma norepinephrine, O2 uptake, and beta-hydroxybutyrate at greater than or equal to 20 mM glucose, and 5) no change in beta-cell response or glucose-induced thermogenesis after one bout of exercise despite no compensating changes in plasma concentrations of hormones or metabolites.	Oxygen	483-485	insulin	Homo sapiens	150-157
2828362-11	1988	This activity is blocked by superoxide dismutase but does not require O2- production by the NADPH-oxidase, indicating that myeloperoxidase produces O2- when incubated with RSH compounds.	Oxygen	148-150	myeloperoxidase	Homo sapiens	123-138
3345578-3	1988	In open, aerobic systems the effective stoichiometry of the reaction between ASC and nitrite is not fixed, but is determined by a competition between the physical removal of NO (and NO2) from the system and the oxidation of NO by dissolved O2.	Oxygen	183-185	PYD and CARD domain containing	Homo sapiens	77-80
2828357-6	1988	NIH/3T3 cells whose content of superoxide dismutase was increased by transcription of the transfected cDNA for the human CuZn superoxide dismutase were also resistant to paraquat, suggesting strongly that paraquat promotes the formation of O2- as a necessary part of its cytotoxic effects in two types of cultured mammalian cells.	Oxygen	240-242	superoxide dismutase 1	Homo sapiens	121-146
2829357-2	1988	Treatment with either native or recombinant somatotropin augmented the production of O2- by both peripheral blood-derived and alveolar macrophages stimulated with opsonized zymosan in vitro.	Oxygen	85-87	growth hormone 1	Rattus norvegicus	44-56
2829357-6	1988	Priming of mononuclear phagocytes for augmented production of reactive oxygen metabolites is a newly defined property of somatotropin.	Oxygen	71-77	growth hormone 1	Rattus norvegicus	121-133
3343911-5	1988	Exercise oxygen consumption averaged 1.54 l.min-1 across all experiments and was equivalent to 60% of arm and 37% of leg peak values.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
3349759-5	1988	The rate of oxygen uptake under maximum exercise was low (26 ml/min-1/kg-1) and was not significantly increased at test 2 and 3.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
2835075-1	1988	Hexanal phenylhydrazone (1; 70:30 E:Z mixture) at micromolar concentration irreversibly inactivates soybean lipoxygenase 1 (L-1) in the presence of dioxygen.	Oxygen	148-156	seed linoleate 13S-lipoxygenase-1	Glycine max	124-127
3345181-5	1988	We found this oxygen system to interfere with the performance of the M-1 and other anti-G maneuvers.	Oxygen	14-20	myoregulin	Homo sapiens	69-89
2831080-2	1988	Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products.	Oxygen	8-14	myeloperoxidase	Homo sapiens	58-61
2831080-2	1988	Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products.	Oxygen	141-147	myeloperoxidase	Homo sapiens	58-61
2841444-2	1988	Inhibition of insulin release from isolated pancreatic islets by exposure to O2(-)-generating system of hypoxanthine-xanthine oxidase].	Oxygen	77-82	insulin	Homo sapiens	14-21
3340731-10	1988	Catalase reduced the rate of oxygen consumption of WR-1065, indicating that peroxide is formed in this system.	Oxygen	29-35	catalase	Homo sapiens	0-8
2829220-9	1988	These data suggest that intranuclear MPO may help to protect DNA against damage resulting from oxygen radicals produced during myeloid cell maturation and function.	Oxygen	95-101	myeloperoxidase	Homo sapiens	37-40
2893528-3	1988	Beta-adrenergic receptor stimulations, by increasing myocardial oxygen demand through augmentation of heart rate and contractility (beta 1), may mediate responses that cause ischemia or perpetuate ischemic episodes induced by other means.	Oxygen	64-70	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	132-138
2854415-0	1988	Electron transfer from cytochrome c to O2.	Oxygen	39-41	cytochrome c, somatic	Homo sapiens	23-35
2826473-10	1988	Catalase was shown to inhibit formation of the hydroxyl radical adduct, further supporting the formation of hydrogen peroxide as an intermediate during the reduction of oxygen.	Oxygen	169-175	catalase	Homo sapiens	0-8
2854415-10	1988	It is proposed that the fast phase of cytochrome c oxidation is the result of electron transfer to O2, either via CuA or direct to the oxygen binding site.	Oxygen	99-101	cytochrome c, somatic	Homo sapiens	38-50
3334851-6	1988	These data are consistent with the possibility that gene dosage of superoxide dismutase 1 contributes to oxygen metabolism modifications previously described in Down"s syndrome.	Oxygen	105-111	superoxide dismutase 1	Homo sapiens	67-89
2854415-1	1988	Transient-state kinetic results on the reaction between oxygen and cytochrome oxidase alone and in its electrostatic complex with cytochrome c are reported.	Oxygen	56-62	cytochrome c, somatic	Homo sapiens	130-142
2854415-10	1988	It is proposed that the fast phase of cytochrome c oxidation is the result of electron transfer to O2, either via CuA or direct to the oxygen binding site.	Oxygen	135-141	cytochrome c, somatic	Homo sapiens	38-50
3140916-3	1988	In this way, the P50 could be changed systematically and the effects on overall O2 transport could be studied.	Oxygen	80-82	nuclear factor kappa B subunit 1	Homo sapiens	17-20
2854994-1	1988	Schemes are presented summarizing current knowledge of the mechanism of action of cytochrome P-450 when it functions either as a monooxygenase with molecular oxygen as the oxygen donor or as a peroxygenase with peroxy compounds as the oxygen donor.	Oxygen	158-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-98
2854994-1	1988	Schemes are presented summarizing current knowledge of the mechanism of action of cytochrome P-450 when it functions either as a monooxygenase with molecular oxygen as the oxygen donor or as a peroxygenase with peroxy compounds as the oxygen donor.	Oxygen	158-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-98
2847661-9	1988	Significant release of .O2- was induced by M-GRAM, TNF, and GM-CSF, whereas H2O2 production was significantly stimulated only by M-GRAM and TNF, as shown by functional and ultrastructural assays.	Oxygen	24-26	tumor necrosis factor	Homo sapiens	51-54
2854994-1	1988	Schemes are presented summarizing current knowledge of the mechanism of action of cytochrome P-450 when it functions either as a monooxygenase with molecular oxygen as the oxygen donor or as a peroxygenase with peroxy compounds as the oxygen donor.	Oxygen	133-139	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-98
3140916-7	1988	The optimal P50, however, depends on the availability of O2: a high P50 is not necessarily beneficial in hypoxia and high cardiac output states.	Oxygen	57-59	nuclear factor kappa B subunit 1	Homo sapiens	12-15
3140916-7	1988	The optimal P50, however, depends on the availability of O2: a high P50 is not necessarily beneficial in hypoxia and high cardiac output states.	Oxygen	57-59	nuclear factor kappa B subunit 1	Homo sapiens	68-71
3208727-3	1988	Since pulmonary oxygen toxicity decreases lung capillary angiotensin converting enzyme (ACE) activity, we assayed converting enzyme active sites in an isolated perfused rat lung preparation as a marker for the development of oxygen toxicity and tolerance.	Oxygen	16-22	angiotensin I converting enzyme	Rattus norvegicus	57-86
3191538-3	1988	Alkylation at N-3 of dCyd resulted in conversion of the adjacent exocyclic imino group at C-4 to an oxygen (hydrolytic deamination) with the formation of a dUrd adduct, 3-HP-dUrd (14%).	Oxygen	100-106	complement C4	Bos taurus	90-93
3073910-7	1988	From kinetic and stereochemical studies with the chicken liver enzyme it has been proposed that the reaction is initiated by the abstraction of a proton from the 3-hydroxyl group of mevalonate 5-diphosphate by a basic group in the enzyme, followed by the nucleophilic attack of the C-3 oxygen on P gamma of the lambda isomer of the beta, gamma bidentate MgATP2- in a SN2(P) reaction that goes with inversion of configuration at P.	Oxygen	286-292	complement component 3	Gallus gallus	282-285
2450692-4	1988	Under these conditions, the content of cytochrome P450 was enhanced concomitantly with increases in the total microsomal oxygen uptake, superoxide radical generation and (+)-catechin (cyanid-3-ol) sensitive respiration.	Oxygen	121-127	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-54
3391031-0	1988	Effect of erythropoietin treatment on O2 affinity and performance in patients with renal anemia.	Oxygen	38-40	erythropoietin	Homo sapiens	10-24
3061793-3	1988	Antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase are responsible for the detoxification of partially reduced oxygen species, superoxide and hydrogen peroxide, to less reactive states.	Oxygen	140-146	catalase	Rattus norvegicus	43-51
3061794-2	1988	Intratracheal insufflation of either liposome encapsulated superoxide dismutase or encapsulated catalase increased levels of enzyme activities in rat lung homogenates and prevented lethal effects of an atmosphere of oxygen.	Oxygen	216-222	catalase	Rattus norvegicus	96-104
2852623-1	1988	It is shown that the copper zinc superoxide dismutase is unique in its ability to catalyze O2- dismutation in vivo in contrast to other copper compounds which have this feature only in vitro.	Oxygen	91-93	superoxide dismutase 1	Homo sapiens	33-53
3208727-3	1988	Since pulmonary oxygen toxicity decreases lung capillary angiotensin converting enzyme (ACE) activity, we assayed converting enzyme active sites in an isolated perfused rat lung preparation as a marker for the development of oxygen toxicity and tolerance.	Oxygen	16-22	angiotensin I converting enzyme	Rattus norvegicus	88-91
3208727-7	1988	Hyperoxia-induced decreases in ACE content were prevented partially by hypoxia adaptation, indicating that ACE content on luminal endothelial surfaces was protected from oxygen toxicity.	Oxygen	170-176	angiotensin I converting enzyme	Rattus norvegicus	107-110
3384343-5	1988	The inhibitory effects of sodium azide, methanol, mannitol, SOD, and catalase suggest an oxygen-dependent mechanism of strand-break production, probably involving hydroxyl radicals.	Oxygen	89-95	catalase	Homo sapiens	69-77
2855420-4	1988	In contrast, the rate of autoxidation of DT-diaphorase-reduced 1,2-naphthoquinone is enhanced by superoxide dismutase, as shown by increased rates of NADPH oxidation, O2 consumption, and H2O2 formation and by an enhanced accumulation of the oxidized product, 1,2-naphthoquinone.	Oxygen	167-169	NAD(P)H quinone dehydrogenase 1	Homo sapiens	41-54
3151488-8	1988	Their properties support, at numerous levels, a major role of SOD in cellular defense against oxygen toxicity.	Oxygen	94-100	superoxide dismutase 1	Homo sapiens	62-65
3193858-0	1988	Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb.	Oxygen	41-47	arginine vasopressin	Rattus norvegicus	0-11
2838494-4	1988	A test for fructosamine quantification is based on nitroblue tetrazolium (NBT) reduction, in which O2- is involved, the reduction being inhibited in the presence of superoxide dismutase (SOD).	Oxygen	99-101	superoxide dismutase 1	Homo sapiens	165-185
2838494-4	1988	A test for fructosamine quantification is based on nitroblue tetrazolium (NBT) reduction, in which O2- is involved, the reduction being inhibited in the presence of superoxide dismutase (SOD).	Oxygen	99-101	superoxide dismutase 1	Homo sapiens	187-190
2846684-4	1988	These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.	Oxygen	117-123	superoxide dismutase 1	Homo sapiens	29-32
3193858-0	1988	Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb.	Oxygen	41-47	angiotensinogen	Rattus norvegicus	16-30
3193858-1	1988	Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb.	Oxygen	51-57	arginine vasopressin	Rattus norvegicus	0-11
3339942-7	1988	The present study indicated that, although in our recent study, skin SOD activity of healthy elderly people was found to be comparable to that in non-aged individuals, the capacity for induction of SOD activity under oxygen stress differed with age in both guinea pig and human burn sufferers.	Oxygen	217-223	superoxide dismutase 1	Homo sapiens	198-201
3193858-1	1988	Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb.	Oxygen	51-57	angiotensinogen	Rattus norvegicus	16-30
3193858-6	1988	The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside.	Oxygen	60-66	arginine vasopressin	Rattus norvegicus	20-31
2460855-6	1988	Our results indicate that toxic oxygen reduction products, available for interception by parenterally administered superoxide dismutase plus catalase, are of only minor importance in the pathogenesis of sodium taurocholate-induced pancreatitis in the rat.	Oxygen	32-38	catalase	Rattus norvegicus	141-149
2849698-11	1988	These results indicate that hypoxia preadaptation minimizes the oxygen-induced decrease in lung microvascular ACE content.	Oxygen	64-70	angiotensin I converting enzyme	Rattus norvegicus	110-113
3691505-8	1987	In summary, these results point to a common role of the thiolate ligand in the oxygen activation mechanism by thromboxane and prostacyclin synthase and liver cytochrome P-450 monooxygenases.	Oxygen	79-85	prostaglandin I2 synthase	Homo sapiens	126-147
2856164-8	1988	The RA metabolism in rat epidermal microsomes shows the typical characteristics of a cytochrome-P-450 (P450)-dependent enzyme system, i.e. a requirement for NADPH and oxygen and inhibition by CO and SKF-525A.	Oxygen	167-173	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	85-101
3062960-11	1988	ACE-inhibitors decrease exaggerated exercise-induced elevation of blood pressure and heart rate and therefore lower myocardial oxygen consumption.	Oxygen	127-133	angiotensin I converting enzyme	Homo sapiens	0-3
3442668-5	1987	The changes in chemical shift that occur when purine riboside binds to the enzyme indicate that the hybridization of C-6 changes from sp2 to sp3 in the binary complex with formation of a new bond to oxygen or sulfur.	Oxygen	199-205	Sp2 transcription factor	Homo sapiens	134-137
3442668-5	1987	The changes in chemical shift that occur when purine riboside binds to the enzyme indicate that the hybridization of C-6 changes from sp2 to sp3 in the binary complex with formation of a new bond to oxygen or sulfur.	Oxygen	199-205	Sp3 transcription factor	Homo sapiens	141-144
2827492-2	1987	In the rat, both IgG and IgA immune complexes induce oxygen radical mediated lung injury that is partially complement-dependent.	Oxygen	53-59	CD79a molecule	Homo sapiens	25-28
2827492-10	1987	Purified human C5a enhanced the O2-.	Oxygen	32-34	complement C5a receptor 1	Homo sapiens	15-18
2902554-6	1988	GRP and CGRP levels decreased less among monkey infants ventilated with oxygen, thus they were significantly higher at 24 hours than in air ventilated controls.	Oxygen	72-78	calcitonin related polypeptide alpha	Homo sapiens	8-12
3693900-7	1987	PGE1 also inhibited FMLP +/- cyto B-induced O2 production in a dose-dependent fashion; phorbol myristate acetate-induced O2 production was also slightly inhibited, but only at high PGE1 concentrations.	Oxygen	44-46	formyl peptide receptor 1	Homo sapiens	20-24
3435817-3	1987	Mean maximal oxygen uptake of the men was 42.1 +/- 8.9 ml.kg-1min-1 with mean values of 41.5 +/- 8.7 ml.kg-1min-1 for the women.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
2827578-7	1987	The activity of microsomal and cytosolic LTA4-hydrolase was decreased in the presence of 100% O2 by 45 and 64%, respectively.	Oxygen	94-96	leukotriene A4 hydrolase	Homo sapiens	41-55
2822236-1	1987	In insulin-producing cells of the RINm5F line, the nonmetabolized analogue of L-leucine, 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid decreases O2 consumption, lowers ATP content, and inhibits insulin release despite stimulation of both NH4 production and 14CO2 output from cells prelabeled with L-[U-14C]glutamine.	Oxygen	146-148	insulin	Homo sapiens	3-10
3125423-6	1987	The PUT1 gene is under oxygen regulation; expression in anaerobically grown cells is 10-fold lower than in aerobically grown cells.	Oxygen	23-29	proline dehydrogenase	Saccharomyces cerevisiae S288C	4-8
3125423-9	1987	Studies on PUT1 promoter deletions define a region between positions -458 and -293 from the translation initiation site that is important for full expression of the PUT1 gene and required for oxygen regulation.	Oxygen	192-198	proline dehydrogenase	Saccharomyces cerevisiae S288C	11-15
2822236-1	1987	In insulin-producing cells of the RINm5F line, the nonmetabolized analogue of L-leucine, 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid decreases O2 consumption, lowers ATP content, and inhibits insulin release despite stimulation of both NH4 production and 14CO2 output from cells prelabeled with L-[U-14C]glutamine.	Oxygen	146-148	insulin	Homo sapiens	195-202
3501227-0	1987	Is oxygen supply the only regulator of erythropoietin levels?	Oxygen	3-9	erythropoietin	Homo sapiens	39-53
3425344-6	1987	When the power output of the bicycle ergometer was increased from 146 +/- 15 to 283 +/- 17 W, oxygen consumption increased from 2.20 +/- 0.98 to 4.22 +/- 0.20 l min-1 (P less than 0.001), while the oxygen consumption at rest was 0.30 +/- 0.03 l min-1.	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	161-166
2963779-6	1987	Physical exercise caused a transient rise of BEP + BLPH plasma levels in both A and C. In A the increase was greater and occurred earlier than in C. The POE release under submaximal exercise showed a close correlation with oxygen uptake and therefore with fitness.	Oxygen	223-229	proopiomelanocortin	Homo sapiens	45-48
3122731-1	1987	The administration of phosphatidic acid to rat livers perfused with media containing either 1.3 mM- or 10 microM-Ca2+ was followed by a stimulation of Ca2+ efflux, O2 uptake and glucose output.	Oxygen	164-166	carbonic anhydrase 2	Rattus norvegicus	113-116
3691953-0	1987	Fast reaction studies of the glycolytic pathway from aldolase to glyceraldehyde-3-phosphate dehydrogenase with physiological concentrations of enzymes: another oxygen-debt mechanism.	Oxygen	160-166	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	65-105
2820530-1	1987	Myeloperoxidase (MPO) is a lysosomal enzyme present in the azurophilic granules of human neutrophils and monocytes and is important for optimal oxygen-dependent killing of microorganisms.	Oxygen	144-150	myeloperoxidase	Homo sapiens	0-15
2820530-1	1987	Myeloperoxidase (MPO) is a lysosomal enzyme present in the azurophilic granules of human neutrophils and monocytes and is important for optimal oxygen-dependent killing of microorganisms.	Oxygen	144-150	myeloperoxidase	Homo sapiens	17-20
3500016-5	1987	Catalase was found in abundance in those structures that are frequently exposed to oxygen metabolites under physiologic conditions and in such pathologic states as intraocular inflammations.	Oxygen	83-89	catalase	Rattus norvegicus	0-8
3691763-3	1987	The proband of each family was found by a simple method determining the oxygen pressure at half hemoglobin saturation (P50), which was used as a screening test evaluating patients with polycythemia.	Oxygen	72-78	nuclear factor kappa B subunit 1	Homo sapiens	119-122
3429387-3	1987	Elimination of O2-dependent antimicrobial systems with retention of phagocytic activity was achieved by using polymorphs from children with chronic granulomatous disease NaF-pulsed normal polymorphs.	Oxygen	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
3687491-2	1987	Catalase activity was determined using an oxygen electrode.	Oxygen	42-48	catalase	Homo sapiens	0-8
3447641-1	1987	A single intravenous injection of recombinant human tumour necrosis factor (TNF) resulted in significant, but transient (24-48 hr) reductions in food intake and body weight, and increases in rectal temperature, resting oxygen consumption (VO2) and brown adipose tissue (BAT) thermogenic activity (mitochondrial GDP-binding).	Oxygen	219-225	tumor necrosis factor	Homo sapiens	52-74
3447641-1	1987	A single intravenous injection of recombinant human tumour necrosis factor (TNF) resulted in significant, but transient (24-48 hr) reductions in food intake and body weight, and increases in rectal temperature, resting oxygen consumption (VO2) and brown adipose tissue (BAT) thermogenic activity (mitochondrial GDP-binding).	Oxygen	219-225	tumor necrosis factor	Homo sapiens	76-79
2820696-0	1987	Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures.	Oxygen	29-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
2820696-8	1987	These results suggest that the enhanced loss of mitochondrial and microsomal cytochrome P-450 activities in cAMP-treated cultures is caused by the increased production of pregnenolone and testosterone, respectively, which generate reactive damaging species derived from reduced dioxygen.	Oxygen	278-286	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
3683155-4	1987	The maximal oxygen uptake achieved in low walking (60.0 +/- 5.8 ml.kg-1.min-1) was not significantly different to that achieved during speed skating (62.1 +/- 6.9), but the maximal level attained in dry skating (48.4 +/- 5.5) was significantly less than both of these.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
3116545-2	1987	This leads to significant rightward shifts of the HbO2 dissociation curves with in vitro P50 (partial pressure of O2 at 50% Hb saturation), values increasing from 32.2 +/- 1.8 torr for control erythrocytes to 86 +/- 60 torr (pH 7.40; PCO2 40 torr at 37 degrees C; 1 torr = 1.333 X 10(2) Pa).	Oxygen	52-54	nuclear factor kappa B subunit 1	Homo sapiens	89-92
2826736-0	1987	Salivary peroxidase: an important part of our defense against oxygen toxicity.	Oxygen	62-68	lactoperoxidase	Homo sapiens	0-19
3116597-6	1987	It was concluded that iv injection of Fluosol DA 20% in conjunction with carbogen breathing significantly increased the O2 transport to hypoxic areas in the SCK tumors and thus significantly enhanced the tumoricidal effect of radiation on SCK tumors.	Oxygen	120-122	SHC (Src homology 2 domain containing) transforming protein 2	Mus musculus	157-160
2820878-5	1987	The phorbol myristate acetate (PMA) or N-formylmethionylleucylphenylalanine (FMLP)-induced O2- release, corrected by surface area, was in the following order: neutrophils greater than cytoplasts greater than karyogranuloplasts.	Oxygen	91-93	formyl peptide receptor 1	Homo sapiens	77-81
3332933-8	1987	We propose that the third oxygenation is initiated by 1 beta-hydrogen abstraction at C1 of 19,19-dihydroxyandrostenedione, followed by homolytic cleavage of the C10-C19 bond with concurrent formation of a delta 1(10),4-3-ketosteroid and a C19 carbon radical, and terminated by oxygen rebound at C19.	Oxygen	26-32	homeobox C10	Homo sapiens	161-164
3631272-18	1987	Increases in O2 uptake caused by epinephrine (0.1 microM) and angiotensin II (5 nM), hormones that increase intracellular Ca2+, were blocked totally by W-7.	Oxygen	13-15	angiotensinogen	Rattus norvegicus	62-76
3622513-9	1987	Both His and Arg can make a hydrogen bond to a phosphate oxygen atom of NAD; hence the lower turnover rate of beta 1 apparently derives from a charge effect.	Oxygen	57-63	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
2826736-5	1987	In saliva the most important part of this defense is salivary peroxidase, which detoxifies hydrogen peroxide in the presence of thiocyanate by converting it into hypothiocyanite, dioxygen and water.	Oxygen	179-187	lactoperoxidase	Homo sapiens	53-72
3629614-7	1987	The recovery of cellular oxygen consumption was examined in detail for CCl4 and correlated with evaporation of the compound.	Oxygen	25-31	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
3624229-5	1987	Chloroperoxidase and cytochrome P-450 thus oxidize styrene by closely related oxygen-transfer mechanisms.	Oxygen	78-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
2889226-6	1987	Enzyme immunosensors with an oxygen electrode have been developed to determine AFP, HCG, IgG and toxin.	Oxygen	29-35	alpha fetoprotein	Homo sapiens	79-82
3039885-7	1987	Cytochrome P-450-dependent monooxygenases are also present in the lung where, in their suggested capacity as oxygen sensors, they generate metabolites of AA that modify pulmonary vasomotion.	Oxygen	31-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
3300657-2	1987	Diclofenac (25-100 micrograms/ml) inhibited the oxygen consumption of PMN stimulated by 5 X 10(-7) M of N-formyl-methionyl-leucyl-phenylalanine (FMLP).	Oxygen	48-54	formyl peptide receptor 1	Homo sapiens	145-149
3039271-4	1987	However, when the rate of oxygen uptake by mitochondria was measured in the presence of rotenone and tetramethyl-p-phenylene-diamine with NADH as substrate, the specific activity in CCl4 treated rats was lower than that of normal rats (Vmax = 345 +/- 31 (e-/s/cytochrome aa3), as compared to Vmax = 408 +/- 21) in spite of the increased activity of cytochrome c oxidase.	Oxygen	26-32	C-C motif chemokine ligand 4	Rattus norvegicus	182-186
3039002-6	1987	The addition of IL 2 to IL 2 receptor-positive monocytes augments their generation of reactive oxygen intermediates and their cytotoxic activity.	Oxygen	95-101	interleukin 2	Homo sapiens	16-20
3039002-6	1987	The addition of IL 2 to IL 2 receptor-positive monocytes augments their generation of reactive oxygen intermediates and their cytotoxic activity.	Oxygen	95-101	interleukin 2	Homo sapiens	24-28
3038186-6	1987	Like reconstitutive activity of succinate dehydrogenase, the antimycin-insensitive succinate-cytochrome c activity of succinate dehydrogenase is sensitive to oxygen; the half-life is about 20 min at 0 degrees C at a protein concentration of 23 mg/ml.	Oxygen	158-164	cytochrome c, somatic	Homo sapiens	93-105
3480764-4	1987	Addition of 75 mumol/l cytochrome C showed that of the consumed oxygen, approximately 80% entered the monovalent pathway of oxygen reduction.	Oxygen	64-70	cytochrome c, somatic	Homo sapiens	23-35
3663400-0	1987	Superoxide dismutase and glutathione peroxidase activities in erythrocytes as indices of oxygen loading in disease: a survey of one hundred cases.	Oxygen	89-95	superoxide dismutase 1	Homo sapiens	0-20
3480764-4	1987	Addition of 75 mumol/l cytochrome C showed that of the consumed oxygen, approximately 80% entered the monovalent pathway of oxygen reduction.	Oxygen	124-130	cytochrome c, somatic	Homo sapiens	23-35
3651273-3	1987	Enzyme solutions were prepared from livers of fetuses and mothers on day 19 of gestation and exposed to air, 50% oxygen or 50% nitrous oxide in oxygen for periods up to 24 h. Normal activity of methionine synthase in the fetus was about 65% of that in the mother.	Oxygen	144-150	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	194-213
3607277-2	1987	Normal human eosinophils were found to respond to formyl-methionyl-leucyl-phenylalanine (fMLP) at concentrations greater than 10(-7) mol/L with an increase in the concentration of intracellular free calcium, oxygen consumption, nitroblue tetrazolium reduction, and chemiluminescence.	Oxygen	208-214	formyl peptide receptor 1	Homo sapiens	89-93
3598003-3	1987	The first 12 months of training resulted in a 44% increase in maximal oxygen consumption (VO2max) from 25.0 +/- 1.3 to 35.9 +/- 1.5 ml X kg-1 X min-1 (p less than 0.001).	Oxygen	70-76	CD59 molecule (CD59 blood group)	Homo sapiens	144-149
3301713-2	1987	In gsh 1 cells the induction of dsb is increased by a factor of 1.5 under oxic and 1.8 under anoxic irradiation conditions: whereas the oxygen enhancement ratio was only slightly decreased (1.9) compared to wild-type cells (2.4).	Oxygen	136-142	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	3-8
3298506-3	1987	Experimental studies have shown that free radical scavengers (e.g., N-[2-mercaptopropionyl]glycine) and enzymes that scavenge or degrade reactive species of oxygen (superoxide dismutase or catalase) can reduce the mass of myocardial tissue that undergoes irreversible injury.	Oxygen	157-163	catalase	Homo sapiens	189-197
3657485-5	1987	Oxygen uptake for the individual exercises ranged from 1.52 l X min-1 (32.6% of TM max) for the behind-neck-press exercise to 2.43 l X min-1 (52.1% of TM max) for the squat exercise.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
3657485-5	1987	Oxygen uptake for the individual exercises ranged from 1.52 l X min-1 (32.6% of TM max) for the behind-neck-press exercise to 2.43 l X min-1 (52.1% of TM max) for the squat exercise.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
3036877-5	1987	Denaturation/increased hydrophobicity of bovine serum albumin (BSA) by .OH, or by .OH + O2- + O2 was maximal at a radical/BSA molar ratio of 24 (all .OH or 50% .OH + 50% O2-).	Oxygen	88-90	albumin	Homo sapiens	48-61
3111319-6	1987	Arachidonic acid (the precursor of PGE2) may inactivates cytochrome P-450, completely reverses the contractile tension of the DA at both low (4 to 12 torr) and high (511 to 712 torr) oxygen tension and is equally effective in the presence and absence of indomethacin.	Oxygen	183-189	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-73
3039121-3	1987	In this study we used a ferricytochrome C reduction microassay to measure superoxide (O2-) production by human polymorphonuclear leukocytes after stimulation with beta-endorphin (beta-END).	Oxygen	86-88	proopiomelanocortin	Homo sapiens	163-177
3039121-3	1987	In this study we used a ferricytochrome C reduction microassay to measure superoxide (O2-) production by human polymorphonuclear leukocytes after stimulation with beta-endorphin (beta-END).	Oxygen	86-88	proopiomelanocortin	Homo sapiens	179-187
3039121-4	1987	beta-END was found to stimulate O2- release at concentrations from 10(-14) to 10(-8) M; the peak response occurred at 10(-12) M. A microassay based on the horseradish peroxidase-mediated oxidation of phenol red was used to demonstrate the production of hydrogen peroxide H2O2, by beta-END at 10(-12) M. The accumulation of H2O2 was reduced by the inhibitor, nitroprusside, and by the converting enzyme, catalase.	Oxygen	32-34	proopiomelanocortin	Homo sapiens	0-8
3037915-6	1987	However, the inability of the adult lung to maintain an increased rate of CuZn SOD synthesis during in vivo hyperoxia may contribute to the poor tolerance of the adult lung to greater than 95% O2.	Oxygen	193-195	superoxide dismutase 1	Rattus norvegicus	74-82
3039546-2	1987	In polymorphonuclear leukocytes phenylacetaldehyde promotes an intracellular O2 consuming process in which myeloperoxidase participates.	Oxygen	77-79	myeloperoxidase	Homo sapiens	107-122
3037304-7	1987	By using molecular oxygen-18 in the in vitro incubation of chrysene and by mass spectral analyses of the resulting oxygen-18-containing dihydrodiol metabolites and their acid-catalyzed dehydration (phenolic) products, both 1,2-epoxide and 3,4-epoxide were found to be converted by microsomal epoxide hydrolase-catalyzed water attack at predominantly (greater than or equal to 97%) the allylic carbons.	Oxygen	115-121	epoxide hydrolase 1	Rattus norvegicus	281-309
2888478-0	1987	Mechanism of oxygen activation by tyrosine hydroxylase.	Oxygen	13-19	tyrosine hydroxylase	Homo sapiens	34-54
3603576-8	1987	CP and acrolein-stimulated lipid peroxidation with and without O2 exposure was significantly (P less than 0.05) reduced by prior addition of SOD, GSH, DTT, or EDTA to the lung microsomal suspension.	Oxygen	63-65	superoxide dismutase 1	Homo sapiens	141-144
2888478-1	1987	The mechanism by which the tetrahydropterin-requiring enzyme tyrosine hydroxylase (TH) activates dioxygen for substrate hydroxylation was explored.	Oxygen	97-105	tyrosine hydroxylase	Homo sapiens	61-81
2888478-1	1987	The mechanism by which the tetrahydropterin-requiring enzyme tyrosine hydroxylase (TH) activates dioxygen for substrate hydroxylation was explored.	Oxygen	97-105	tyrosine hydroxylase	Homo sapiens	83-85
2888478-3	1987	These results are in accord with shared mechanisms of oxygen activation by TH and the more commonly studied tetrahydropterin-dependent enzyme phenylalanine hydroxylase (PAH) and strongly suggest that a peroxytetrahydropterin is the hydroxylating species generated during TH turnover.	Oxygen	54-60	tyrosine hydroxylase	Homo sapiens	75-77
2888478-6	1987	While the overall pattern of tetrahydropterin-dependent oxygen activation by TH and PAH is similar, the H2O2-dependent hydroxylation performed by TH provides an indication that subtle differences in the Fe ligand field exist between the two enzymes.	Oxygen	56-62	tyrosine hydroxylase	Homo sapiens	77-79
3109259-2	1987	In the present study, xanthine oxidase-derived oxygen metabolites from endogenous substrates elicited vasodilation that was selectively and almost completely inhibited by catalase but not by superoxide dismutase.	Oxygen	47-53	catalase	Rattus norvegicus	171-179
3593708-0	1987	Stabilization effect of tocopherol and catalase on the life-time of liposome-embedded heme as an oxygen carrier.	Oxygen	97-103	catalase	Homo sapiens	39-47
3607022-4	1987	The quenching rate constant (at 21 degrees C) for oxygen is kq = (9.6 +/- 0.9) X 10(7) M-1 S-1, only 1 order of magnitude less than that for Zn-hematoporphyrin quenching in aqueous solution.	Oxygen	50-56	tumor associated calcium signal transducer 2	Homo sapiens	87-94
2822673-5	1987	Myeloperoxidase compound I reacted with H2O2 and returned to the ferric state with concomitant evolution of an O2 molecule.	Oxygen	42-44	myeloperoxidase	Homo sapiens	0-15
3036006-5	1987	The addition of superoxide dismutase, catalase, or both superoxide dismutase and catalase decreased the rate of oxygen consumption.	Oxygen	112-118	catalase	Homo sapiens	38-46
3036006-5	1987	The addition of superoxide dismutase, catalase, or both superoxide dismutase and catalase decreased the rate of oxygen consumption.	Oxygen	112-118	catalase	Homo sapiens	81-89
2884009-1	1987	Intracellular thiols (LSH), superoxide dismutase (SOD) and plasma thiols (PSH) are thought to have an important role in the protection of tissues from damage by oxygen-derived free radicals.	Oxygen	161-167	helicase, lymphoid specific	Homo sapiens	22-25
2884009-1	1987	Intracellular thiols (LSH), superoxide dismutase (SOD) and plasma thiols (PSH) are thought to have an important role in the protection of tissues from damage by oxygen-derived free radicals.	Oxygen	161-167	superoxide dismutase 1	Homo sapiens	28-48
2884009-1	1987	Intracellular thiols (LSH), superoxide dismutase (SOD) and plasma thiols (PSH) are thought to have an important role in the protection of tissues from damage by oxygen-derived free radicals.	Oxygen	161-167	superoxide dismutase 1	Homo sapiens	50-53
2822673-4	1987	As for the latter, true catalase activity of myeloperoxidase was demonstrated by monitoring O2 evolution after the injection of H2O2 into the enzyme solution.	Oxygen	92-94	catalase	Homo sapiens	24-32
3606920-6	1987	Up to 11 days exposure of rats to 80% oxygen was not lethal, but resulted in overt cellular damage to red blood cells (haemoglobin concentration decreased from 13.8 +/- 1.4 (SD) g dl-1 to 12.4 +/- 0.5 g dl-1; hydrogen peroxide-induced haemolysis increased from 7.7 +/- 1.6% to 75.1 +/- 13.5% after 11 days of hyperoxia) and to cells of lung (4-fold increase in lipid peroxidation) as well as a biochemical adaptation to the increased concentration of oxygen metabolites (superoxide dismutase increased 3-fold, catalase 5-fold and glutathione peroxidase 2-fold).	Oxygen	38-44	catalase	Rattus norvegicus	510-518
2822673-4	1987	As for the latter, true catalase activity of myeloperoxidase was demonstrated by monitoring O2 evolution after the injection of H2O2 into the enzyme solution.	Oxygen	92-94	myeloperoxidase	Homo sapiens	45-60
3035015-2	1987	In this study, we evaluated the influence of morphine and the stress responsive opioid peptide beta-endorphin (beta-END) on O-2 and H2O2 production by cultured human peripheral blood mononuclear cells.	Oxygen	124-127	proopiomelanocortin	Homo sapiens	95-109
3035015-2	1987	In this study, we evaluated the influence of morphine and the stress responsive opioid peptide beta-endorphin (beta-END) on O-2 and H2O2 production by cultured human peripheral blood mononuclear cells.	Oxygen	124-127	proopiomelanocortin	Homo sapiens	111-119
3035015-3	1987	Exposure of these cells during 48 hr of culture to morphine and beta-END at pharmacologically (10(-8) M) and physiologically (10(-12) M) relevant concentrations, respectively, markedly suppressed peripheral blood mononuclear cell O-2 and H2O2 release in response to the respiratory burst stimuli opsonized zymosan and phorbol myristate acetate.	Oxygen	230-233	proopiomelanocortin	Homo sapiens	64-72
3035015-5	1987	The modulatory effects of morphine and beta-END on peripheral blood mononuclear cell oxygen metabolism appeared to involve a classical opioid receptor, because opioid activity was blocked by naloxone and was not observed with N-acetylated-beta-END.	Oxygen	85-91	proopiomelanocortin	Homo sapiens	39-47
3032620-4	1987	The results obtained show that, whilst ferrocytochrome c pulses of the aerobic oxidase vesicles at neutral pH and in the presence of saturating concentrations of valinomycin and K+ to ensure charge compensation produced H+/e- ratios around 1 (as has been shown previously), oxygen pulses of reduced anaerobic vesicles supplemented with cytochrome c, gave H+/e- ratios around 0.3.	Oxygen	274-280	cytochrome c, somatic	Homo sapiens	44-56
3650694-5	1987	The activity as measured by oxygen uptake was inhibited by cyanide, EDTA, mannitol, histidine, ascorbate, noradrenaline, adriamycin, cytochrome c, Mn2+, superoxide dismutase, horseradish peroxidase and catalase.	Oxygen	28-34	catalase	Rattus norvegicus	202-210
3650694-9	1987	Addition of excess catalase or SOD abolished the oxygen uptake while retaining significant rates of NADH disappearance indicating that the two activities are delinked.	Oxygen	49-55	catalase	Rattus norvegicus	19-27
3650695-7	1987	Catalase and Mn2+, which inhibit oxygen consumption accompanying NADH oxidation, increased both the rate and extent of the blue color compound formed.	Oxygen	33-39	catalase	Rattus norvegicus	0-8
3571267-8	1987	Rat hydroxyindole-O-methyltransferase is also inactivated in the absence of added disulfides and dissolved O2.	Oxygen	107-109	acetylserotonin O-methyltransferase	Rattus norvegicus	4-37
3593796-6	1987	Addition of catalase to the experimental cell causes O2 release.	Oxygen	53-55	catalase	Rattus norvegicus	12-20
3579000-5	1987	Treatment with 50% oxygen produced delayed increases in nonprotein sulfhydryl (NPSH) content and catalase (CAT) activity, while treatment with 65% oxygen produced delayed increases in NPSH, CAT, and glutathione peroxidase (GPx) content.	Oxygen	19-25	catalase	Rattus norvegicus	97-105
3579000-7	1987	Rats exposed to 80% oxygen had significantly decreased body weight, increased lung-to-body weight ratios, and increased levels of NPSH, CAT, GPx, total superoxide dismutase, and glutathione reductase by 11 days of treatment.	Oxygen	20-26	catalase	Rattus norvegicus	136-139
3115606-0	1987	Augmentation of antibody-dependent cellular cytotoxicity of polymorphonuclear leukocytes by interferon-gamma: mechanism dependent on enhancement of Fc receptor expression and increased release of activated oxygens.	Oxygen	206-213	interferon gamma	Homo sapiens	92-108
3553851-0	1987	Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients.	Oxygen	83-89	insulin	Homo sapiens	22-29
3583984-4	1987	Cells cultured in 220 microM O2 (air) also exhibited a gradual loss of cytochrome P-450, so that by 9 h of incubation less than 60% of the active material remained.	Oxygen	29-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	71-87
3821364-1	1987	We studied 35 patients with active inflammatory skin diseases, measuring the levels of lipidperoxides and of the oxygen radical scavenging enzyme superoxide dismutase (SOD) in biopsy specimens of skin lesions.	Oxygen	113-119	superoxide dismutase 1	Homo sapiens	146-166
2441083-4	1987	These results suggest that cytochrome c is directly reduced by the cuprous ion released from bleomycin-Cu (II) in a reducing reaction with cysteine and nitroblue tetrazolium chloride is reduced by the superoxide anion formed in the reaction of the cuprous ion with oxygen.	Oxygen	265-271	cytochrome c, somatic	Homo sapiens	27-39
3030427-7	1987	Concomitantly, Compound I of myeloperoxidase would be reduced to Compound II and superoxide anions would be generated from oxygen.	Oxygen	123-129	myeloperoxidase	Homo sapiens	29-44
3559801-3	1987	Elevated erythropoietin values in cyanotic patients were associated with lower mixed venous oxygen saturation and tension than in cyanotic patients with normal erythropoietin levels, even though the degree of polycythemia was similar.	Oxygen	92-98	erythropoietin	Homo sapiens	9-23
3559801-5	1987	Of the blood oxygen measurements, mixed venous oxygen saturation and tension had the closest inverse correlation with erythropoietin values.	Oxygen	13-19	erythropoietin	Homo sapiens	118-132
3559801-5	1987	Of the blood oxygen measurements, mixed venous oxygen saturation and tension had the closest inverse correlation with erythropoietin values.	Oxygen	47-53	erythropoietin	Homo sapiens	118-132
3299003-1	1987	In bacterial cells near-ultraviolet radiation (NUV) generates H2O2 which can be decomposed by endogenous catalase to H2O and O2.	Oxygen	64-66	catalase	Homo sapiens	105-113
3105540-5	1987	The results suggest that cytochrome P-450 may catalyse its own inactivation by virtue of greater free radical production under conditions which favour the non-oxygen dependent metabolism of halothane.	Oxygen	159-165	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
3821364-1	1987	We studied 35 patients with active inflammatory skin diseases, measuring the levels of lipidperoxides and of the oxygen radical scavenging enzyme superoxide dismutase (SOD) in biopsy specimens of skin lesions.	Oxygen	113-119	superoxide dismutase 1	Homo sapiens	168-171
3594320-2	1987	This study describes the inhibitory influence of an acute exposure to hypoxia (14.5% O2) on the blood PRL response induced by graded maximal exercise in eight trained male subjects.	Oxygen	85-87	prolactin	Homo sapiens	102-105
3826206-3	1987	When compared with results in the control group, maximal oxygen uptake (ml/kg1 X min1) decreased significantly in the oral contraceptive users during the 6-month period of observation.	Oxygen	57-63	CD59 molecule (CD59 blood group)	Homo sapiens	81-85
3030331-6	1987	Both the reduction of the quinone imines and the reduction of oxygen were found to be cytochrome P-450 dependent.	Oxygen	62-68	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	86-102
3030331-0	1987	Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen.	Oxygen	144-150	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-56
3828510-2	1987	It can be concluded that the decrease in superoxide dismutase and catalase activity in experimental alloxan diabetes is mainly connected with the decline in the content of these proteins at the terminal stages of the disease, this, probably, being the result of DNA degradation and RNA transport disturbances under the effect of oxygen active forms.	Oxygen	329-335	catalase	Rattus norvegicus	66-74
3559330-13	1987	When the O2 concentration was increased, MAPO2 also increased.	Oxygen	9-11	sperm tail PG-rich repeat containing 1	Homo sapiens	41-46
3600619-0	1987	[Electron factors in the properties of cytochrome P-450 and mechanism of activation of molecular oxygen].	Oxygen	97-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-55
2880566-19	1987	Inactivation required molecular oxygen and is partially inhibited by Mn(II), catalase, superoxide dismutase, and metal chelators, ethylenediaminetetraacetic acid and o-phenanthroline.	Oxygen	32-38	catalase	Homo sapiens	69-85
3802439-5	1987	P50, 2,3-DPG, hemoglobin concentrations, and O2 saturation varied widely and inconsistently with Po2 and arterial and venous O2 content, but resulted in clustering of the arterial oxygen content near 165 +/- 23 (SD) ml/liter over a wide range of Po2 and hemoglobin concentrations.	Oxygen	125-127	nuclear factor kappa B subunit 1	Homo sapiens	0-3
3802439-5	1987	P50, 2,3-DPG, hemoglobin concentrations, and O2 saturation varied widely and inconsistently with Po2 and arterial and venous O2 content, but resulted in clustering of the arterial oxygen content near 165 +/- 23 (SD) ml/liter over a wide range of Po2 and hemoglobin concentrations.	Oxygen	180-186	nuclear factor kappa B subunit 1	Homo sapiens	0-3
3101517-3	1987	Asphyxia [arterial O2 partial pressure (PaO2) = 40-50 Torr, arterial CO2 partial pressure (PaCO2) = 60-80 Torr) increases plasma lysine vasopressin (LVP) from 2.2 +/- 0.8 to 52.4 +/- 15.0 microU/ml.	Oxygen	19-21	vasopressin	Sus scrofa	136-147
2433158-2	1987	The Na+ channel blockers, ajmaline, tetracaine, bipuvacaine, lidocaine and etmozine produced an increase in the amount of O2- reacting with SOD.	Oxygen	122-124	superoxide dismutase 1	Homo sapiens	140-143
3678214-0	1987	Regulation of growth hormone during exercise by oxygen demand and availability.	Oxygen	48-54	growth hormone 1	Homo sapiens	14-28
2441682-1	1987	Aerobic incubations of bleomycin, FeCl3, DNA, NADPH, and isolated liver microsomal NADPH-cytochrome P-450 reductase resulted in NADPH and oxygen consumption and malondialdehyde formation, indicating that the deoxyribose moiety of DNA was split.	Oxygen	138-144	cytochrome p450 oxidoreductase	Homo sapiens	83-115
2441682-9	1987	These results indicate that nuclear NADPH-cytochrome P-450 reductase redox cycles the bleomycin-Fe(III/II) complex and that the reduced complex activates oxygen, whereby hydroxyl radicals are formed which damage the deoxyribose of nuclear DNA.	Oxygen	154-160	cytochrome p450 oxidoreductase	Homo sapiens	36-68
3508430-3	1987	Addition of superoxide dismutase or catalase clearly suppressed the ethanol-induced release of GPT and SDH, suggesting that .O2- and H2O2 are involved in this process.	Oxygen	125-127	catalase	Rattus norvegicus	36-44
3623187-2	1987	Superoxide dismutase, catalase, or glutathione peroxidase provided some protection when injected in the cells exposed to O2.	Oxygen	121-123	catalase	Homo sapiens	22-30
3329689-5	1987	It may be postulated that VIP plays a role in securing ample oxygen supply to functioning sweat glands, especially with a relatively high cutaneous vasoconstrictor tone.	Oxygen	61-67	vasoactive intestinal peptide	Homo sapiens	26-29
3429244-7	1987	The P50 of the oxygen equilibrium curve of whole blood at 37 degrees C was 38 torr compared with controls of 27 +/- 2 torr.	Oxygen	15-21	nuclear factor kappa B subunit 1	Homo sapiens	4-7
3429244-8	1987	The P50 binding studies of the isolated Hb Chico revealed a unique right shift of the equilibrium curve with an oxygen binding constant (1/P50) about half of normal.	Oxygen	112-118	nuclear factor kappa B subunit 1	Homo sapiens	4-7
3429244-8	1987	The P50 binding studies of the isolated Hb Chico revealed a unique right shift of the equilibrium curve with an oxygen binding constant (1/P50) about half of normal.	Oxygen	112-118	nuclear factor kappa B subunit 1	Homo sapiens	139-142
3663951-1	1987	The normal response to anemic or hypoxic hypoxia is synthesis and release of erythropoietin in accord with the concept that erythropoietin production is controlled by a renal oxygen sensor.	Oxygen	175-181	erythropoietin	Homo sapiens	77-91
3663951-1	1987	The normal response to anemic or hypoxic hypoxia is synthesis and release of erythropoietin in accord with the concept that erythropoietin production is controlled by a renal oxygen sensor.	Oxygen	175-181	erythropoietin	Homo sapiens	124-138
24435718-3	1987	The addition of catalase to the membrane suspension completely inhibits O2 produced by the first two flashes, but not by subsequent flashes.	Oxygen	72-74	catalase	Homo sapiens	16-24
3449750-2	1987	The first proposed step is enzymatic alpha-hydroxylation by the active oxygen species of cytochrome P-450, followed by nonenzymatic N-dealkylation and formation of diazohydroxides (RNNOH).	Oxygen	71-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105
3575886-3	1987	These results are in line with the hypothesis that ischemia results in an accumulation of hypoxanthine and a conversion of xanthine dehydrogenase into its O2-dependent form.	Oxygen	155-157	xanthine dehydrogenase/oxidase	Felis catus	123-145
3099838-2	1986	In aqueous solution, the bimolecular quenching constants (k*) for lipid-free apo A-I fluorescence quenching by oxygen and acrylamide are 2.4 X 10(9) and 0.38 X 10(9) M-1 s-1, respectively.	Oxygen	111-117	apolipoprotein A1	Homo sapiens	77-84
3482484-13	1987	The oxygen affinity shows a small decrease (p50 increases from 3.05 to 5.27 kPa) on addition of IHP.	Oxygen	4-10	nuclear factor kappa B subunit 1	Homo sapiens	44-47
2830721-3	1987	After a comprehensive treatment including oxygen therapy the blood concentrations of hydrocortisone, ACTH, 17-hydroxycorticosteroids fell to levels found in healthy persons.	Oxygen	42-48	proopiomelanocortin	Homo sapiens	101-105
3099838-6	1986	The apparent k* for oxygen quenching of apo A-I fluorescence in the complex is large and increases in a temperature-dependent manner.	Oxygen	20-26	apolipoprotein A1	Homo sapiens	40-47
3099838-7	1986	We have introduced a two-compartment model, which discriminates the source of quencher molecules as aqueous or lipid, to describe oxygen quenching of DMPC/apo A-I fluorescence.	Oxygen	130-136	apolipoprotein A1	Homo sapiens	155-162
3032917-3	1986	SOD inhibited the DCIP reduction by chemically generated O2- in the same manner as the stimulation-specific DCIP reduction by the macrophage F2, and the concentration of SOD necessary for 50% inhibition was about 10 times that for the reduction of cytochrome c. Under anaerobic conditions, however, the NADPH oxidase could reduce DCIP, though the rate was slow because we could not use a sufficiently high DCIP concentration.	Oxygen	57-59	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	0-3
2836672-2	1987	The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation.	Oxygen	118-124	interferon gamma	Homo sapiens	34-50
2836672-2	1987	The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation.	Oxygen	118-124	interferon gamma	Homo sapiens	52-61
2836672-2	1987	The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation.	Oxygen	118-124	interferon gamma	Homo sapiens	191-200
2836672-8	1987	H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2.	Oxygen	2-4	interferon gamma	Homo sapiens	55-64
2836672-8	1987	H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2.	Oxygen	2-4	interferon gamma	Homo sapiens	164-173
3032917-3	1986	SOD inhibited the DCIP reduction by chemically generated O2- in the same manner as the stimulation-specific DCIP reduction by the macrophage F2, and the concentration of SOD necessary for 50% inhibition was about 10 times that for the reduction of cytochrome c. Under anaerobic conditions, however, the NADPH oxidase could reduce DCIP, though the rate was slow because we could not use a sufficiently high DCIP concentration.	Oxygen	57-59	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	170-173
3021236-1	1986	A mitochondrial preparation from duck adrenal gland was used, under aerobic conditions, to show that the oxygen requirement for the last step of aldosterone biosynthesis (transformation of 18-hydroxycorticosterone into aldosterone) is at the cytochrome P-450 level only.	Oxygen	105-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	242-258
3540607-1	1986	In Saccharomyces cerevisiae the anaerobic (oxygen-repressed) ANB1 gene and a group of aerobic (oxygen-induced) genes are coordinately regulated by the ROX1 gene.	Oxygen	43-49	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	61-65
3540607-1	1986	In Saccharomyces cerevisiae the anaerobic (oxygen-repressed) ANB1 gene and a group of aerobic (oxygen-induced) genes are coordinately regulated by the ROX1 gene.	Oxygen	43-49	Rox1p	Saccharomyces cerevisiae S288C	151-155
3540607-1	1986	In Saccharomyces cerevisiae the anaerobic (oxygen-repressed) ANB1 gene and a group of aerobic (oxygen-induced) genes are coordinately regulated by the ROX1 gene.	Oxygen	95-101	Rox1p	Saccharomyces cerevisiae S288C	151-155
3786144-7	1986	The spectroscopically detectable structural perturbations caused by replacement of phosphate oxygen with sulfur were mostly localized within the GsA moiety, and were greater for the Rp configuration wherein sulfur is oriented into the major groove of the B-helix.	Oxygen	93-99	GNAS complex locus	Homo sapiens	145-148
3021236-2	1986	Vitamin C and tetramethyl-p-phenylene-diamine (TMPD) were used to increase oxygen consumption at the cytochrome a3 level, thereby decreasing its availability to cytochrome P-450.	Oxygen	75-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-177
3021236-8	1986	According to polarographic and electron microscopy studies, the reversal of inhibition can only be explained by an increased availability of oxygen at the cytochrome P-450 level.	Oxygen	141-147	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	155-171
3021236-9	1986	Experiments performed under aerobic conditions, without a nitrogen atmosphere, show that oxygen is required in the transformation of 18-hydroxycorticosterone into aldosterone, at the cytochrome P-450 level.	Oxygen	89-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	183-199
3770101-5	1986	At reduced oxygen tension, the sensitivity of early and late erythroid progenitor cells to erythropoietin was significantly increased, and this can be one of the mechanisms for the enhanced colony growth of erythroid progenitors.	Oxygen	11-17	erythropoietin	Homo sapiens	91-105
3789739-4	1986	Cytochrome P-450 substrates and inhibitors decreased the extents and initial rates of oxygen uptake and thiobarbituric acid reactive product formation.	Oxygen	86-92	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
3019528-4	1986	Crocidolite toxicity to both primary cultures of mouse peritoneal macrophages and P388D1 cells, a mouse macrophage-like cell line, could be prevented by a hypoxic environment or by addition of the reactive oxygen metabolite scavengers, superoxide dismutase and catalase.	Oxygen	206-212	catalase	Mus musculus	261-269
2429877-9	1986	Remarkably, both Fe X BLM and Cu X BLM were also shown to be activated by NADPH cytochrome P-450 reductase in a transformation that was dependent on metal ion, O2 and NADPH.	Oxygen	160-162	cytochrome p450 oxidoreductase	Homo sapiens	74-106
3021740-0	1986	The mechanism by which oxygen and cytochrome c increase the rate of electron transfer from cytochrome a to cytochrome a3 of cytochrome c oxidase.	Oxygen	23-29	cytochrome c, somatic	Homo sapiens	124-136
3021740-5	1986	Using the kinetic constants that are known for this reaction, we find that the activating effects of O2 and cytochrome c on the rate of electron transfer from cytochrome a to cytochrome a3 conform to the predictions of the model and so provide no evidence of any allosteric effects or control of cytochrome c oxidase by O2 or cytochrome c.	Oxygen	101-103	cytochrome c, somatic	Homo sapiens	296-308
3021740-5	1986	Using the kinetic constants that are known for this reaction, we find that the activating effects of O2 and cytochrome c on the rate of electron transfer from cytochrome a to cytochrome a3 conform to the predictions of the model and so provide no evidence of any allosteric effects or control of cytochrome c oxidase by O2 or cytochrome c.	Oxygen	101-103	cytochrome c, somatic	Homo sapiens	296-308
3021740-5	1986	Using the kinetic constants that are known for this reaction, we find that the activating effects of O2 and cytochrome c on the rate of electron transfer from cytochrome a to cytochrome a3 conform to the predictions of the model and so provide no evidence of any allosteric effects or control of cytochrome c oxidase by O2 or cytochrome c.	Oxygen	320-322	cytochrome c, somatic	Homo sapiens	108-120
3795277-8	1986	The rate of oxygen uptake was significantly higher under all experimental conditions in perfused hearts from tumor-bearing rats compared with hearts from starved, PCM and freely-fed control rats.	Oxygen	12-18	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	163-166
22283296-0	1986	Oxygen activation by metalloporphyrins related to peroxidase and cytochrome P-450.	Oxygen	0-6	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81
3795277-9	1986	Oxygen uptake per left ventricular work was significantly higher in tumor-bearing rats but significantly lower in starved and PCM rats compared with control animals.	Oxygen	0-6	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	126-129
2876985-14	1986	The Ca2+-induced potentiation of oxygen free radical injury likely is due in part to activation of phospholipase A2.	Oxygen	33-39	phospholipase A2 group IB	Homo sapiens	99-115
3021721-2	1986	During the GSH oxidation catalyzed by lactoperoxidase, O2 was consumed and the formation of glutathione free radical was confirmed by ESR of its 5,5"-dimethyl-1-pyrroline-N-oxide adduct.	Oxygen	55-57	lactoperoxidase	Homo sapiens	38-53
3021721-3	1986	When lactoperoxidase was replaced by thyroid peroxidase in the reaction system, the consumption of O2 and the formation of the free radical became negligibly small.	Oxygen	99-101	lactoperoxidase	Homo sapiens	5-20
3024362-2	1986	The reduction of cytochrome c by O2- formed by KO2 was observed only above pH 7.0 and demonstrated a pH optimum at pH 9.6.	Oxygen	33-35	cytochrome c, somatic	Homo sapiens	17-29
3800956-4	1986	Oxygen inactivates rat lung galaptin by oxidation of the cysteine residues.	Oxygen	0-6	galectin 1	Rattus norvegicus	28-36
3766745-2	1986	In isolated rat kidneys perfused with cell-free medium, oxidative metabolism to support reabsorptive transport in the presence of a limited oxygen supply results in hypoxic injury to medullary thick ascending limbs (mTAL).	Oxygen	140-146	talipes	Mus musculus	216-220
3766750-2	1986	At a concentration of 878 +/- 15 pg/ml, AVP produced significant (P less than 0.05) decreases in coronary flow (-31 +/- 2%); myocardial O2 consumption (-12 +/- 2%); left ventricular peak systolic pressure (-5 +/- 1%); dP/dtmax (-7 +/- 1%); -dP/dtmax (-6 +/- 3%); peak aortic flow rate (-5 +/- 1%); stroke work (-3 +/- 1%); peak power (-8 +/- 1%); and total output (-3 +/- 1%).	Oxygen	136-138	arginine vasopressin	Rattus norvegicus	40-43
3095231-0	1986	The influence of interferon-gamma and various phagocytic stimuli on the expression of MHC-class II antigens on human monocytes--relation to the generation of reactive oxygen intermediates.	Oxygen	167-173	interferon gamma	Homo sapiens	17-33
3586103-5	1986	Maximum oxygen uptake was increased by 18% post-training (3.29 +/- 0.29 1 min-1 versus 3.89 +/- 0.49 1 min-1; P less than 0.01), but endurance at the same absolute work rate as pre-training was increased by more than 200% (32.2 +/- 11.4 min versus 97.8 +/- 27.3 min; P less than 0.01).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	74-79
3586103-5	1986	Maximum oxygen uptake was increased by 18% post-training (3.29 +/- 0.29 1 min-1 versus 3.89 +/- 0.49 1 min-1; P less than 0.01), but endurance at the same absolute work rate as pre-training was increased by more than 200% (32.2 +/- 11.4 min versus 97.8 +/- 27.3 min; P less than 0.01).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
3800956-9	1986	In contrast, alkylation with iodoacetamide yields carboxamidomethyl-galaptin, which is fully active and stable to atmospheric oxygen in the absence of disulphide-reducing reagents.	Oxygen	126-132	galectin 1	Rattus norvegicus	68-76
3020020-5	1986	Here we report that if resting oxidase is incubated with either reduced or oxidized cytochrome c and then exposed to dioxygen, an activated form is rapidly produced which appears to be more oxidized than the starting material.	Oxygen	117-125	cytochrome c, somatic	Homo sapiens	84-96
2945777-7	1986	These results would suggest that IFN-gamma is the component of the lymphokine that is largely or exclusively responsible for H2O2 production, while other factors in addition to IFN-gamma are important in promoting oxygen-independent mechanisms for the killing of intracellular L. major amastigotes.	Oxygen	214-220	interferon gamma	Homo sapiens	177-186
3091694-11	1986	This decrease was reversed by catalase and superoxide dismutase, which suggests the involvement of oxygen radicals.	Oxygen	99-105	catalase	Rattus norvegicus	30-38
3741876-1	1986	We have studied the effect of sodium maleate on the reaction of haemoglobin with oxygen at various temperatures between 10 degrees C and 30 degrees C. At all the temperatures investigated, the presence of sodium maleate causes a significant increase of log p50.	Oxygen	81-87	nuclear factor kappa B subunit 1	Homo sapiens	257-260
3759784-2	1986	Copper-deficient rats have increased susceptibility to O2 toxicity, which may be related to their decreased lung superoxide dismutase activity (SOD) or decreased plasma ceruloplasmin concentrations.	Oxygen	55-57	superoxide dismutase 1	Rattus norvegicus	144-147
3019692-11	1986	In the absence of cytochrome c, electron transfer from tetramethylphenylenediamine to the oxidase to oxygen results in the conversion of the resting form to the "oxygenated"; in the presence of cytochrome c, the same electron transfer results in the appearance of the "pulsed" form.	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	18-30
3019692-11	1986	In the absence of cytochrome c, electron transfer from tetramethylphenylenediamine to the oxidase to oxygen results in the conversion of the resting form to the "oxygenated"; in the presence of cytochrome c, the same electron transfer results in the appearance of the "pulsed" form.	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	194-206
3091386-9	1986	The presence of a factor demonstrating functional similarity with Interleukin-3 was produced optimally under 5% oxygen-tension conditions.	Oxygen	112-118	interleukin 3	Mus musculus	66-79
3091496-5	1986	Gradual recovery of FMLP-induced O2- generation occurs when cells are transferred from Ca2+-free to Ca2+-containing medium.	Oxygen	33-35	formyl peptide receptor 1	Homo sapiens	20-24
2942503-6	1986	Thus, under these experimental conditions, the enhancement ratio of the HpD action (defined as the ratio of the durations of irradiation necessary to obtain the cessation of Ca2+ uptake before and after addition of a component other than HpD) is of the order of 40, 10 and 5 for oxygen, misonidazole and metronidazole, respectively.	Oxygen	279-285	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	72-75
2432586-1	1986	Neuroactive peptides, including the enkephalins (Met- and Leu-enkephalin; ME, LE) and substance P (SP) are known to be present in the mammalian carotid body, an arterial chemoreceptor organ sensitive to the O2, CO2 and pH levels in blood.	Oxygen	207-209	tachykinin precursor 1	Homo sapiens	86-97
2432586-1	1986	Neuroactive peptides, including the enkephalins (Met- and Leu-enkephalin; ME, LE) and substance P (SP) are known to be present in the mammalian carotid body, an arterial chemoreceptor organ sensitive to the O2, CO2 and pH levels in blood.	Oxygen	207-209	tachykinin precursor 1	Homo sapiens	99-101
3733673-3	1986	Cytochrome c554, the primary electron donor to P865+ of the reaction center, is not present in dark-grown respiratory cells but is induced in parallel with bacteriochlorophylls a and c and at similar oxygen partial pressure.	Oxygen	200-206	cytochrome c, somatic	Homo sapiens	0-12
3017361-2	1986	The possibility that the active oxygen participating in the above reaction is the superoxide anion (O2-) or a species generated from O2- was examined with the help of superoxide dismutase (SOD) and with an SOD-mimetic agent, CuDIPS [Cu2+(3,5-diisopropylsalicylic acid)2].	Oxygen	32-38	superoxide dismutase 1	Homo sapiens	167-187
3017361-2	1986	The possibility that the active oxygen participating in the above reaction is the superoxide anion (O2-) or a species generated from O2- was examined with the help of superoxide dismutase (SOD) and with an SOD-mimetic agent, CuDIPS [Cu2+(3,5-diisopropylsalicylic acid)2].	Oxygen	32-38	superoxide dismutase 1	Homo sapiens	189-192
3017361-2	1986	The possibility that the active oxygen participating in the above reaction is the superoxide anion (O2-) or a species generated from O2- was examined with the help of superoxide dismutase (SOD) and with an SOD-mimetic agent, CuDIPS [Cu2+(3,5-diisopropylsalicylic acid)2].	Oxygen	32-38	superoxide dismutase 1	Homo sapiens	206-209
3017361-2	1986	The possibility that the active oxygen participating in the above reaction is the superoxide anion (O2-) or a species generated from O2- was examined with the help of superoxide dismutase (SOD) and with an SOD-mimetic agent, CuDIPS [Cu2+(3,5-diisopropylsalicylic acid)2].	Oxygen	100-102	superoxide dismutase 1	Homo sapiens	206-209
3776462-7	1986	Similar examination of each individual"s catalase activity indicated an increase after exposure to both 10% O2 and 100% O2 at 2 ata.	Oxygen	108-110	catalase	Homo sapiens	41-49
3776462-7	1986	Similar examination of each individual"s catalase activity indicated an increase after exposure to both 10% O2 and 100% O2 at 2 ata.	Oxygen	120-122	catalase	Homo sapiens	41-49
2426956-7	1986	Raising intracellular Ca2+ by the calcium ionophore A23187 evoked the same pattern of Cl- loss and O2 uptake as carbachol.	Oxygen	99-101	carbonic anhydrase 2	Rattus norvegicus	22-25
3088106-0	1986	Oxygen-independent inhibition of intracellular Chlamydia psittaci growth by human monocytes and interferon-gamma-activated macrophages.	Oxygen	0-6	interferon gamma	Homo sapiens	96-112
3762123-0	1986	Protection against oxygen-induced reperfusion injury of the isolated canine heart by superoxide dismutase and catalase.	Oxygen	19-25	catalase	Canis lupus familiaris	110-118
3762123-5	1986	Coronary flow was significantly higher in the heart treated with SOD and catalase during the working stage with a corresponding increase in oxygen consumption.	Oxygen	140-146	catalase	Canis lupus familiaris	73-81
3088106-7	1986	The induction of this apparently oxygen-independent antichlamydial effect by lymphokine was completely neutralized by a monoclonal anti-IFN-gamma antibody, and could be achieved by treatment with recombinant (r)IFN-gamma alone.	Oxygen	33-39	interleukin 2	Homo sapiens	77-87
3487575-3	1986	The production of oxygen metabolites by IgE-coated platelets, stimulated by anti-IgE or the specific antigen, was, likewise, strongly inhibited by this lymphokine.	Oxygen	18-24	immunoglobulin heavy constant epsilon	Homo sapiens	40-43
3088106-7	1986	The induction of this apparently oxygen-independent antichlamydial effect by lymphokine was completely neutralized by a monoclonal anti-IFN-gamma antibody, and could be achieved by treatment with recombinant (r)IFN-gamma alone.	Oxygen	33-39	interferon gamma	Homo sapiens	136-145
3487575-3	1986	The production of oxygen metabolites by IgE-coated platelets, stimulated by anti-IgE or the specific antigen, was, likewise, strongly inhibited by this lymphokine.	Oxygen	18-24	immunoglobulin heavy constant epsilon	Homo sapiens	81-84
3088106-7	1986	The induction of this apparently oxygen-independent antichlamydial effect by lymphokine was completely neutralized by a monoclonal anti-IFN-gamma antibody, and could be achieved by treatment with recombinant (r)IFN-gamma alone.	Oxygen	33-39	interferon gamma	Homo sapiens	211-220
3024626-8	1986	Glucagon, phenylephrine and vasopressin caused a substantial and transient rise in NAD(P)H fluorescence, but a sustained increase in cytochrome c/c1 reduction and the rates of O2 consumption and gluconeogenesis.	Oxygen	176-178	arginine vasopressin	Rattus norvegicus	28-39
2425252-5	1986	The results indicate that BP-3,6-dione undergoes two-electron reduction to an unstable hydroquinone, BP-3,6-diol, or one-electron reduction to a semiquinone radical intermediate and that both of these reduced forms undergo rapid univalent oxidation to generate active reduced oxygen species.	Oxygen	276-282	BP3	Homo sapiens	26-30
2425252-6	1986	The data are consistent with the hypothesis that active oxygen species generated by BP-dione/BP-diol redox cycling are responsible, at least in part, for the mutagenic and cytotoxic effects observed with BP-3,6-dione.	Oxygen	56-62	BP3	Homo sapiens	204-208
3521420-5	1986	Oxygen delivery was calculated as the product of cardiac output (thermodilution) and arterial blood oxygen content (Lex-O2-Con analyzer).	Oxygen	0-6	fucosyltransferase 4	Homo sapiens	116-119
3018103-2	1986	The ability of different IFN species to induce xanthine oxidase correlated with their ability to depress liver cytochrome P-450-dependent drug metabolism, supporting the hypothesis that reactive oxygen metabolites generated by xanthine oxidase might be responsible for this impairment of liver function by IFN.	Oxygen	195-201	interferon alpha 1	Homo sapiens	25-28
3015634-3	1986	Reproducible measurement of O2- formation required the presence of 0.2 mmol l-1 KCN to inhibit a cytochrome oxidase activity found in the cytochrome C preparation used.	Oxygen	28-30	cytochrome c, somatic	Homo sapiens	138-150
3018103-2	1986	The ability of different IFN species to induce xanthine oxidase correlated with their ability to depress liver cytochrome P-450-dependent drug metabolism, supporting the hypothesis that reactive oxygen metabolites generated by xanthine oxidase might be responsible for this impairment of liver function by IFN.	Oxygen	195-201	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-127
3018103-2	1986	The ability of different IFN species to induce xanthine oxidase correlated with their ability to depress liver cytochrome P-450-dependent drug metabolism, supporting the hypothesis that reactive oxygen metabolites generated by xanthine oxidase might be responsible for this impairment of liver function by IFN.	Oxygen	195-201	interferon alpha 1	Homo sapiens	306-309
3702587-4	1986	In cataractous lenses the enzymic defenses against reactive species of O2 were impaired as evidenced by the significant decrease in activities of superoxide dismutase, catalase and glutathione peroxidase.	Oxygen	71-73	catalase	Homo sapiens	168-176
3790079-3	1986	Molecular-mechanics calculations with the three-dimensional structural co-ordinates of catalase shows that these proportions of products can be accounted for by the relative accessibility of the four methene bridges to a haem-linked oxygen molecule, thus further confirming Brown"s [(1976) Biochem.	Oxygen	233-239	catalase	Homo sapiens	87-95
3083850-1	1986	The insufflation of oxygen at 1 litre kg-1 min-1 via two endobronchial catheters (called continuous flow ventilation (CFV)) maintained a normal PaCO2 and a constant PaO2 in anaesthetized paralysed dogs and in five out of seven cats.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
3083850-3	1986	In five patients, endobronchial insufflation of oxygen 0.5 litre kg-1 min-1 caused approximately a 30% decrease in the increase in PaCO2 compared with apnoeic oxygenation (P less than 0.05) during a period of 6 min.	Oxygen	48-54	CD59 molecule (CD59 blood group)	Homo sapiens	70-75
3710978-4	1986	Alveolar-to-arterial O2 tension difference increased linearly with O2 uptake (VO2) (6.1 Torr X min-1 X 1(-1) VO2).	Oxygen	21-23	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
3710978-4	1986	Alveolar-to-arterial O2 tension difference increased linearly with O2 uptake (VO2) (6.1 Torr X min-1 X 1(-1) VO2).	Oxygen	67-69	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
2423850-5	1986	Like the CTT1 gene, this gene is controlled by heme, oxygen and glucose.	Oxygen	53-59	catalase T	Saccharomyces cerevisiae S288C	9-13
3755593-3	1986	It has the ability to catalyse the oxidative incorporation of iron into transferrin at very low Fe2+ and O2 concentrations.	Oxygen	105-107	transferrin	Rattus norvegicus	72-83
3949114-3	1986	Treatment with 2 atm of O2 for 6 h after intragastric administration of CCl4 (2.6 mmol/100 g) improved survival from 31% to 96%.	Oxygen	24-26	C-C motif chemokine ligand 4	Rattus norvegicus	72-76
3949114-7	1986	Hyperbaric O2 treatment inhibited in vivo conversion of CCl4 to its volatile metabolites CHCl3 and CO2 by 52% in the 10 h following CCl4 dosing.	Oxygen	11-13	C-C motif chemokine ligand 4	Rattus norvegicus	56-60
3949114-7	1986	Hyperbaric O2 treatment inhibited in vivo conversion of CCl4 to its volatile metabolites CHCl3 and CO2 by 52% in the 10 h following CCl4 dosing.	Oxygen	11-13	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
3949114-9	1986	Studies with hepatic microsomes isolated from these rats demonstrated that hyperbaric O2 treatment diminished their capacity to metabolize CCl4 to CO2, and O2-dependent process.	Oxygen	86-88	C-C motif chemokine ligand 4	Rattus norvegicus	139-143
3949114-9	1986	Studies with hepatic microsomes isolated from these rats demonstrated that hyperbaric O2 treatment diminished their capacity to metabolize CCl4 to CO2, and O2-dependent process.	Oxygen	148-150	C-C motif chemokine ligand 4	Rattus norvegicus	139-143
3949114-11	1986	These results indicate that hyperbaric O2 suppresses the microsomal mechanism for metabolizing CCl4 in the presence of O2.	Oxygen	39-41	C-C motif chemokine ligand 4	Rattus norvegicus	95-99
3949114-11	1986	These results indicate that hyperbaric O2 suppresses the microsomal mechanism for metabolizing CCl4 in the presence of O2.	Oxygen	119-121	C-C motif chemokine ligand 4	Rattus norvegicus	95-99
3949114-12	1986	Because the mechanism of CCl4 hepatotoxicity is thought to be the same in the rat and in humans, hyperbaric O2 therapy is recommended for treatment of CCl4 poisoning in humans.	Oxygen	108-110	C-C motif chemokine ligand 4	Rattus norvegicus	25-29
3711889-2	1986	Evidence for a hemoglobin-catalase-superoxide dismutase integrated system in the oxygen depletion by dithionite.	Oxygen	81-87	catalase	Homo sapiens	26-34
3711889-3	1986	Calorimetric studies of the effect of superoxide dismutase and/or catalase on the reduction of dioxygen into water by dithionite in oxyhemoglobin have been carried out and the results compared with those in red cell hemolysates.	Oxygen	95-103	catalase	Homo sapiens	66-74
3514679-4	1986	The addition of catalase, however, decreased oxygen consumption by nearly one-half, which suggests that H2O2 was formed during the reaction.	Oxygen	45-51	catalase	Homo sapiens	16-24
3961822-6	1986	In separate experiments, 100% O2 exposure significantly decreased lung CuZn-SOD activity by 40% while IPL histamine and MDA were significantly increased.	Oxygen	30-32	superoxide dismutase 1	Rattus norvegicus	71-79
3961822-7	1986	However, exposure of rats to 65% O2 for 5 days decreased lung CuZn-SOD by 69% but did not affect IPL histamine release or perfusate MDA.	Oxygen	33-35	superoxide dismutase 1	Rattus norvegicus	62-70
3712445-0	1986	Mini-myoglobin: preparation and reaction with oxygen and carbon monoxide.	Oxygen	46-52	myoglobin	Equus caballus	5-14
3712445-3	1986	Flash photolysis experiments have shown that reconstituted "mini-myoglobin" is very similar to myoglobin in the combination reaction with carbon monoxide and with oxygen, and in the oxygen replacement reaction by carbon monoxide.	Oxygen	163-169	myoglobin	Equus caballus	65-74
3712445-3	1986	Flash photolysis experiments have shown that reconstituted "mini-myoglobin" is very similar to myoglobin in the combination reaction with carbon monoxide and with oxygen, and in the oxygen replacement reaction by carbon monoxide.	Oxygen	182-188	myoglobin	Equus caballus	65-74
3084387-4	1986	The myocardial oxygen balance estimated from the supply/demand ratio (DPTI/SPTI) was significantly reduced after acetate dialysis and significantly lower than during bicarbonate dialysis (p less than 0.05).	Oxygen	15-21	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	75-79
3004619-5	1986	Catalase and superoxide dismutase inhibited postbinding lytic events, indicating that production of reduced oxygen moieties was important.	Oxygen	108-114	catalase	Mus musculus	0-8
3486047-4	1986	Catalase partially prevents the loss of EIC, suggesting that hydrogen peroxide produced from the reduction of oxygen in cigarette smoke extracts is responsible for at least some of the smoke-induced inactivation.	Oxygen	110-116	catalase	Homo sapiens	0-8
3524875-0	1986	Disulfide cleavage and insulin denaturation by active oxygen in the copper(II)/ascorbic acid system.	Oxygen	54-60	insulin	Homo sapiens	23-30
3084387-5	1986	After 90 min acetate dialysis DPTI/SPTI dropped to its lowest value as a result of an excess of myocardial oxygen demand (SPTI) over myocardial oxygen supply (DPTI), signifying transient hypoperfusion of the subendocardium which did not occur during bicarbonate dialysis.	Oxygen	107-113	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	35-39
3084387-5	1986	After 90 min acetate dialysis DPTI/SPTI dropped to its lowest value as a result of an excess of myocardial oxygen demand (SPTI) over myocardial oxygen supply (DPTI), signifying transient hypoperfusion of the subendocardium which did not occur during bicarbonate dialysis.	Oxygen	107-113	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	122-126
3084387-5	1986	After 90 min acetate dialysis DPTI/SPTI dropped to its lowest value as a result of an excess of myocardial oxygen demand (SPTI) over myocardial oxygen supply (DPTI), signifying transient hypoperfusion of the subendocardium which did not occur during bicarbonate dialysis.	Oxygen	144-150	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	35-39
3950443-3	1986	Neutralization of O2-dependent antimicrobial systems with retention of phagocytic capacity was achieved with use of PMNLs from four children with chronic granulomatous disease (CGD) or NaF-pulsed normal PMNLs.	Oxygen	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
3526580-9	1986	All these findings indicated that P. berghei-infected mice caused a depressed catalase activity in red cells and liver which was possibly due to the catalatic function in detoxifying the increased H2O2 to water and free oxygen.	Oxygen	220-226	catalase	Mus musculus	78-86
3014489-4	1986	Oxygen consumption was substantial and could be maintained for at least 5 h. Adrenocorticotrophic hormone (ACTH) concentrations in the effluent buffer were estimated by radioimmunoassay and bioassay.	Oxygen	0-6	proopiomelanocortin	Homo sapiens	107-111
3088264-2	1986	When rats were ventilated to produce physiological Pa, CO2 levels (35-40 mmHg) responses to boluses of angiotensin II were greater with increasing Pa, O2 over the Pa, O2 range of 65-460 mmHg.	Oxygen	56-58	angiotensinogen	Rattus norvegicus	103-117
3088264-2	1986	When rats were ventilated to produce physiological Pa, CO2 levels (35-40 mmHg) responses to boluses of angiotensin II were greater with increasing Pa, O2 over the Pa, O2 range of 65-460 mmHg.	Oxygen	151-153	angiotensinogen	Rattus norvegicus	103-117
3088264-4	1986	All variations in response to angiotensin II were attributable to changes in Pa, O2.	Oxygen	81-83	angiotensinogen	Rattus norvegicus	30-44
3088264-5	1986	Since arterial blood gas tensions, especially the Pa, O2, modulate pressor responses to boluses of angiotensin II, the physiological effects of this hormone may be most fruitfully explored in rats ventilated to produce normal arterial blood gas tensions.	Oxygen	54-56	angiotensinogen	Rattus norvegicus	99-113
3558757-4	1986	On the basis of measurements of ovine granulosa cell respiration in vitro, the model predicts that a large pre-antral follicle with a radius of 0.15 mm consumes oxygen at the rate of 0.22 nmol min-1.	Oxygen	161-167	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
3458447-4	1986	The mean maximum oxygen uptake (VO2max) of the CAPD patients was reduced considerably (14.6 ml kg-1 min-1) compared with matched control subjects (33.6 ml kg-1 min-1).	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	100-105
3000576-7	1986	Although most of the XP syndrome could be explained by the impairment in the excision repair ability, the decrease in catalase activity leading to a probable increase in intracellular H2O2 concentration and/or to a higher sensitivity to any oxygen-activated species could represent an additive effect in inducing the carcinogenic process.	Oxygen	241-247	catalase	Homo sapiens	118-126
3081497-2	1986	The steroid binding specificity of cytochrome P-450scc has been investigated for different oxidation/reduction and ligand-binding states of the enzyme (oxidized, reduced, oxygen-bound, and carbon monoxide-bound forms).	Oxygen	171-177	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	35-54
3003077-3	1986	Cytochrome c can replace oxygen as the final electron acceptor, indicating that a one-electron transfer takes place.	Oxygen	25-31	cytochrome c, somatic	Homo sapiens	0-12
2935379-3	1986	The estimated hepatic oxygen consumption also was significantly correlated with the serum albumin level, 15-min retention rate of indocyanine green, and prothrombin time.	Oxygen	22-28	albumin	Homo sapiens	90-97
3005565-2	1986	The IR and ESR spectral studies imply dibasic tetradentate behavior of the ligand bonding through "thiolo" sulfur, enolic oxygen, and hydrazinic nitrogens in a polymeric structure.	Oxygen	122-128	esterase 5 regulator	Mus musculus	11-14
3949654-5	1986	New male and female recruits representing a young civilian population entered the service with maximal O2 uptake of 51 and 37 ml X kg body wt-1 X min-1, respectively, and thereafter increased 5% during initial basic training.	Oxygen	103-105	CD59 molecule (CD59 blood group)	Homo sapiens	146-151
3525152-0	1986	Growth hormone regulation in two types of aerobic exercise of equal oxygen uptake.	Oxygen	68-74	growth hormone 1	Homo sapiens	0-14
3024427-6	1986	Reduction of cytochrome-c and nitro-tetrazolium-blue by O2- generated by xanthine oxidase is inhibited by heme-nonapeptide.	Oxygen	56-58	cytochrome c, somatic	Homo sapiens	13-25
2934991-7	1986	Hexokinase and phosphofructokinase activities were not altered substantially when studied under conditions of O2 excess.	Oxygen	110-112	hexokinase 1	Homo sapiens	0-10
3021423-0	1986	[Inactivation of active forms of oxygen generated by myeloperoxidase and serum proteins].	Oxygen	33-39	myeloperoxidase	Homo sapiens	53-68
3549274-7	1986	The high content of antioxidant compounds in the adrenal cortex, principally ascorbate, may serve to protect cytochrome P-450 enzymes from the damaging effects of oxygen radical species formed as a result of cytochrome P-450/pseudosubstrate interactions.	Oxygen	163-169	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-125
3699008-2	1986	On the morning after a previous day"s "low-energy" intake (LE regimen) of 4.5 MJ, the mean resting oxygen consumption increased by 0.7 ml X kg-1 X min-1 after the test meal (P less than 0.025).	Oxygen	99-105	CD59 molecule (CD59 blood group)	Homo sapiens	147-152
3699008-6	1986	Oxygen consumption during exercise increased after feeding by 0.5 ml X kg-1 X min-1 on the LE regimen (n.s.)	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
3490371-4	1986	While, for CPA, the half-time of the early phase of the time-activity curve was a function of myocardial oxygen consumption (MVO2), this phase was not found to reflect the oxidative metabolism of IHA.	Oxygen	105-111	carboxypeptidase A1	Homo sapiens	11-14
3007082-3	1986	In whole lungs of rats exposed to 85% oxygen there is an increase in activity (per lung or per mg lung DNA) in the antioxidant enzymes CuZn superoxide dismutase, Mn superoxide dismutase, catalase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.	Oxygen	38-44	catalase	Rattus norvegicus	187-195
3549274-7	1986	The high content of antioxidant compounds in the adrenal cortex, principally ascorbate, may serve to protect cytochrome P-450 enzymes from the damaging effects of oxygen radical species formed as a result of cytochrome P-450/pseudosubstrate interactions.	Oxygen	163-169	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	208-224
3698986-4	1986	During weight lifting, mean oxygen uptake and heart rate were 1.96 L X min-1 and 158 bt X min-1, respectively.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	71-95
3098815-3	1986	We argue that this was due to the effect of hypophosphatemia on respiratory muscle- and heart function and P50, leading to impaired oxygen delivery.	Oxygen	132-138	nuclear factor kappa B subunit 1	Homo sapiens	107-110
3957410-4	1986	As target cell lysis is totally or partially inhibited by catalase, sodium azide and potassium cyanide, an involvement of toxic oxygen derivatives as cytolytic mediators was suggested.	Oxygen	128-134	catalase	Homo sapiens	58-66
2878523-3	1986	Treatment with hyperbaric oxygen decreases carbon tetrachloride (CCl4)-induced necrosis in a manner dependent upon duration and pressure of oxygen exposure.	Oxygen	26-32	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
3711943-2	1986	With decreasing temperature, P50 (the oxygen tension [PO2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension (PvO2) and thus low tissue PO2 values.	Oxygen	38-44	nuclear factor kappa B subunit 1	Homo sapiens	29-32
3711943-2	1986	With decreasing temperature, P50 (the oxygen tension [PO2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension (PvO2) and thus low tissue PO2 values.	Oxygen	93-99	nuclear factor kappa B subunit 1	Homo sapiens	29-32
3711943-2	1986	With decreasing temperature, P50 (the oxygen tension [PO2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension (PvO2) and thus low tissue PO2 values.	Oxygen	93-99	nuclear factor kappa B subunit 1	Homo sapiens	29-32
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	47-54	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	84-103
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	47-54	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	191-206
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	217-224	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	84-103
3294992-3	1986	To evaluate the neonates" ability to respond to an oxygen challenge with increased superoxide dismutase (SOD), 9 prematures were studied immediately at birth and on days 1, 3, 5, and 7.	Oxygen	51-57	superoxide dismutase 1	Homo sapiens	83-103
3294992-3	1986	To evaluate the neonates" ability to respond to an oxygen challenge with increased superoxide dismutase (SOD), 9 prematures were studied immediately at birth and on days 1, 3, 5, and 7.	Oxygen	51-57	superoxide dismutase 1	Homo sapiens	105-108
2878523-3	1986	Treatment with hyperbaric oxygen decreases carbon tetrachloride (CCl4)-induced necrosis in a manner dependent upon duration and pressure of oxygen exposure.	Oxygen	140-146	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
2878523-5	1986	Hyperbaric oxygen treatment before or immediately after CCl4 intoxication is protective.	Oxygen	11-17	C-C motif chemokine ligand 4	Rattus norvegicus	56-60
3953118-3	1986	The new process is based on the idea to use the late phase of high temperature for the evocation of the detected connection process of blood microcirculation by a supply of 25 l min-1 of pure oxygen lasting 25 minutes (via a mask applicator).	Oxygen	192-198	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
2878523-6	1986	Loss of protection is rapid; hyperbaric oxygen treatment 6 h after CCl4 intoxication augments the liver necrosis.	Oxygen	40-46	C-C motif chemokine ligand 4	Rattus norvegicus	67-71
2867745-1	1985	Mixed-function oxidation of Escherichia coli glutamine synthetase by ascorbate, oxygen, and iron has previously been shown to cause inactivation of the enzyme and enhanced susceptibility to proteolytic attack by a variety of proteases.	Oxygen	80-86	glutamate-ammonia ligase	Homo sapiens	45-65
2997155-5	1985	Consistent with a suicidal process, inactivation of the LTB4 omega-hydroxylase requires molecular oxygen and NADPH, is time-dependent, and follows pseudo-first-order kinetics.	Oxygen	98-104	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-78
3913744-5	1985	Damage to DNA could be prevented by oxygen scavengers such as superoxide dismutase, catalase, mannitol and thiourea.	Oxygen	36-42	catalase	Homo sapiens	84-92
3000943-13	1985	FMLP and A23187 were similar to the soluble IgG aggregates in their effects and induced release of proportionately more O2- than H2O2.	Oxygen	120-122	formyl peptide receptor 1	Homo sapiens	0-4
4071455-2	1985	At an outlet flow of 2 l min-1 the mean % O2 generated by all models, except the Permox (which was lower, mean (SD) 90.5% (3.1%), were between 94% and 95% with a range of less than +/- 0.5%.	Oxygen	42-44	CD59 molecule (CD59 blood group)	Homo sapiens	25-30
4074778-1	1985	The two main approaches presently used for cytochrome P-450scc modelling are as follows: i) the use of chemical compounds carrying activated oxygen species, e. g., peracids, organic hydroperoxides, iodosobenzene, etc., ii) the use of electrochemical reduction in the presence of redox-active compounds.	Oxygen	141-147	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	43-62
4057091-5	1985	The femoral arterial-venous oxygen difference at maximum work averaged 14.6% (v/v), resulting in an oxygen uptake of 0.80 l min-1.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
3928752-0	1985	The synergistic influence of human interferon-gamma and interferon-alpha on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro.	Oxygen	215-221	interferon gamma	Homo sapiens	35-51
3928752-7	1985	Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together.	Oxygen	18-20	interferon gamma	Homo sapiens	75-84
3928752-7	1985	Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together.	Oxygen	18-20	interferon alpha 1	Homo sapiens	88-97
3928752-7	1985	Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together.	Oxygen	18-20	interferon gamma	Homo sapiens	160-169
3928752-7	1985	Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together.	Oxygen	18-20	interferon alpha 1	Homo sapiens	174-183
3928523-5	1985	Opsonized zymosan and N-formylmethionylleucylphenylalanine (FMLP) were used to stimulate neutrophil oxygen consumption and lysosomal release.	Oxygen	100-106	formyl peptide receptor 1	Homo sapiens	60-64
4046869-9	1985	It was demonstrated that, within the hematocrit range of 20 to 45%, the elevation of P50 from 27 to 38 mm Hg in sickle cell blood is adequate to compensate for the diminished O2 content, despite an elevated blood viscosity, and maintain near normal tissue pO2.	Oxygen	175-177	nuclear factor kappa B subunit 1	Homo sapiens	85-88
4074290-9	1985	The yield of biochemical energy from the perfusion fluid (utilized for contraction and heat production) was (on average) 21 J per cm3 oxygen consumption (energy equivalent of oxygen).	Oxygen	134-140	Cardiac mass QTL 3	Rattus norvegicus	130-133
4074290-9	1985	The yield of biochemical energy from the perfusion fluid (utilized for contraction and heat production) was (on average) 21 J per cm3 oxygen consumption (energy equivalent of oxygen).	Oxygen	175-181	Cardiac mass QTL 3	Rattus norvegicus	130-133
4074501-3	1985	The hemiketal complex of thrombin and p-APPA may be further stabilized by a hydrogen bond between a carboxylate oxygen of p-APPA and the N tau-atom (= N epsilon 2) of His57, as was previously shown for the trypsin-p-APPA complex by X-ray crystal structure analysis by J. Walter and W. Bode.	Oxygen	112-118	coagulation factor II, thrombin	Homo sapiens	25-33
4044832-6	1985	LTB4 omega-hydroxylase activity in isolated PMN membranes was linear with respect to duration of incubation and protein concentration, was maximal at pH 7.4, had a Km for LTB4 of 0.6 microM, and was dependent on oxygen and on reduced pyridine nucleotides (apparent Km for NADPH = 0.5 microM; apparent Km for NADH = 223 microM).	Oxygen	212-218	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-22
3906268-2	1985	The subjects with electroencephalographic and sensory signs of stimulating reticular-hypothalamic-amygdalic effects balanced with inhibitory cortical-striatic-septic-hippocampal-epiphyseal effects showed a high oxygen consumption, moderate excretion of epinephrine and norepinephrine, moderate plasma concentrations of ACTH, cortisol, total and free 11-OHCS and insulin, relatively high concentrations of STH, as well as specific dynamics of hormonal and metabolic reactions to aerobic effects.	Oxygen	211-217	proopiomelanocortin	Homo sapiens	319-323
3906268-2	1985	The subjects with electroencephalographic and sensory signs of stimulating reticular-hypothalamic-amygdalic effects balanced with inhibitory cortical-striatic-septic-hippocampal-epiphyseal effects showed a high oxygen consumption, moderate excretion of epinephrine and norepinephrine, moderate plasma concentrations of ACTH, cortisol, total and free 11-OHCS and insulin, relatively high concentrations of STH, as well as specific dynamics of hormonal and metabolic reactions to aerobic effects.	Oxygen	211-217	insulin	Homo sapiens	362-369
4057091-5	1985	The femoral arterial-venous oxygen difference at maximum work averaged 14.6% (v/v), resulting in an oxygen uptake of 0.80 l min-1.	Oxygen	100-106	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
4040516-0	1985	Dynamics of dioxygen and carbon monoxide binding to soybean leghemoglobin.	Oxygen	12-20	leghemoglobin A	Glycine max	60-73
4025577-6	1985	A maternal placental blood flow of less than 200 ml X min-1 X kg fetal wt-1 produces a steady-state value of oxygen tension in the fetal ascending aorta of less than 17 mmHg, which is incompatible with normal oxygen delivery.	Oxygen	109-115	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
4025577-7	1985	A minimal value of umbilical flow providing an adequate oxygen supply to the fetal body is 87 ml X min-1 X kg fetal wt-1.	Oxygen	56-62	CD59 molecule (CD59 blood group)	Homo sapiens	99-104
3894498-6	1985	Cellular processes that maintain high ionic gradients appear especially vulnerable to the superoxide anion, thus necessitating the presence of CuZn SOD to scavenge toxic free radicals of oxygen.	Oxygen	187-193	superoxide dismutase 1	Rattus norvegicus	143-151
4040516-1	1985	The association of dioxygen and carbon monoxide to soybean leghemoglobin (Lb) has been studied by laser flash photolysis at temperatures from 10 to 320 K and times from 50 ns to 100 s. Infrared spectra of the bound and the photodissociated state were investigated between 10 and 20 K. The general features of the binding process in leghemoglobin are similar to the ones found in myoglobin.	Oxygen	19-27	leghemoglobin A	Glycine max	59-72
4040516-1	1985	The association of dioxygen and carbon monoxide to soybean leghemoglobin (Lb) has been studied by laser flash photolysis at temperatures from 10 to 320 K and times from 50 ns to 100 s. Infrared spectra of the bound and the photodissociated state were investigated between 10 and 20 K. The general features of the binding process in leghemoglobin are similar to the ones found in myoglobin.	Oxygen	19-27	leghemoglobin A	Glycine max	74-76
4040516-1	1985	The association of dioxygen and carbon monoxide to soybean leghemoglobin (Lb) has been studied by laser flash photolysis at temperatures from 10 to 320 K and times from 50 ns to 100 s. Infrared spectra of the bound and the photodissociated state were investigated between 10 and 20 K. The general features of the binding process in leghemoglobin are similar to the ones found in myoglobin.	Oxygen	19-27	leghemoglobin A	Glycine max	332-345
4039766-4	1985	Maximal oxygen uptake increased significantly in both groups: 11 mL O2/kg/min-1 or 30% in the sedentary group and 6 mL O2/kg/min-1 or 13% in the monozygotic twins.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	74-79
2989007-2	1985	Titration of the reaction with SOD and a comparison with that of xanthine oxidase showed that the inhibition was not due to the semiquinone oxidation accelerated by a removal of O2- but due to the accelerated dismutation of O2- which otherwise reduces the quinone.	Oxygen	178-180	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	31-34
2989007-2	1985	Titration of the reaction with SOD and a comparison with that of xanthine oxidase showed that the inhibition was not due to the semiquinone oxidation accelerated by a removal of O2- but due to the accelerated dismutation of O2- which otherwise reduces the quinone.	Oxygen	224-226	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	31-34
3927975-1	1985	Both purified cytochrome P-450 (P-450) and free ferriprotoporphyrin IX are destroyed by NADPH-P-450 reductase in the presence of NADPH and O2.	Oxygen	139-141	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
4039766-4	1985	Maximal oxygen uptake increased significantly in both groups: 11 mL O2/kg/min-1 or 30% in the sedentary group and 6 mL O2/kg/min-1 or 13% in the monozygotic twins.	Oxygen	68-70	CD59 molecule (CD59 blood group)	Homo sapiens	74-79
4039766-4	1985	Maximal oxygen uptake increased significantly in both groups: 11 mL O2/kg/min-1 or 30% in the sedentary group and 6 mL O2/kg/min-1 or 13% in the monozygotic twins.	Oxygen	119-121	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
4007180-7	1985	Liposome entrapment of both SOD and catalase significantly increased the circulating half-lives of these enzymes and was critical for prevention of in vivo oxygen toxicity.	Oxygen	156-162	catalase	Rattus norvegicus	36-44
4020882-0	1985	Involvement of hydrogen peroxide and hydroxyl radical in the "oxygen paradox": reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase.	Oxygen	62-68	catalase	Homo sapiens	119-127
4014861-0	1985	Protection against pulmonary oxygen toxicity in rats by the intratracheal administration of liposome-encapsulated superoxide dismutase or catalase.	Oxygen	29-35	catalase	Rattus norvegicus	138-146
2992614-3	1985	It was shown that active oxygen species are generated via consecutive one-electron reduction of the oxygen molecule by NADPH-cytochrome P-450 reductase.	Oxygen	25-31	cytochrome p450 oxidoreductase	Homo sapiens	119-151
2860872-11	1985	It has now been found that in the presence of Fe(III), O2, and an appropriate electron donor (hypoxanthine or NADPH, respectively) glutamine synthetase is also inactivated by either milk xanthine oxidase or Clostridial nicotinate hydroxylase.	Oxygen	55-57	glutamate-ammonia ligase	Homo sapiens	131-151
2992614-3	1985	It was shown that active oxygen species are generated via consecutive one-electron reduction of the oxygen molecule by NADPH-cytochrome P-450 reductase.	Oxygen	100-106	cytochrome p450 oxidoreductase	Homo sapiens	119-151
2409069-6	1985	Furthermore, activities of catalase and superoxide dismutase in lung homogenates were higher than control and were further augmented by exposure to 100% O2 for 64 h. These biochemical changes may account, at least in part, for the mitigation of the toxic effects of hyperoxia, as shown by the delayed appearance of arterial hypoxemia, and the 50% increase in survival time when bleomycin injected rabbits were exposed to 100% O2 35 days postinjection.	Oxygen	153-155	catalase	Oryctolagus cuniculus	27-35
2409069-6	1985	Furthermore, activities of catalase and superoxide dismutase in lung homogenates were higher than control and were further augmented by exposure to 100% O2 for 64 h. These biochemical changes may account, at least in part, for the mitigation of the toxic effects of hyperoxia, as shown by the delayed appearance of arterial hypoxemia, and the 50% increase in survival time when bleomycin injected rabbits were exposed to 100% O2 35 days postinjection.	Oxygen	426-428	catalase	Oryctolagus cuniculus	27-35
2408615-1	1985	We report the full structure of two elliptinium diribonucleosides monophosphate adducts: the oxidized form of this antitumor agent alkylates very selectively the pX ribose of ApX (X = G or U) leading to a spiro derivative, where the C10 atom of ellipticine skeleton is linked to both sugar oxygen atoms 2" and 3".	Oxygen	290-296	homeobox C10	Homo sapiens	233-236
3840888-6	1985	The oxidation-induced loss of activity of unsubstituted PDH may result from introduction of oxygen (in methionine sulfone) and a consequent conformational change in the octadecapeptide.	Oxygen	92-98	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	56-59
4026964-4	1985	The estimated hepatic oxygen consumption correlated positively with prothrombin time and serum albumin level, and negatively with the fifteen minute retention rate of indocyanine green.	Oxygen	22-28	albumin	Homo sapiens	95-102
4053242-0	1985	Oxygen activation and olefin oxygenation by iron(III)porphyrin as a model of cytochrome P-450.	Oxygen	0-6	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-93
3985174-3	1985	The high OHA state resulted from standard storage conditions, which caused depressed values of DPG and P50 (the oxygen tension at which hemoglobin is 50% saturated).	Oxygen	112-118	nuclear factor kappa B subunit 1	Homo sapiens	103-106
2985426-3	1985	CO, which inhibits the cytochrome P-450-dependent oxygen radical formation, had no effect on the oxidation reaction, suggesting that the source of the reactive oxygen species is not the microsomal mixed-function oxidase.	Oxygen	50-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-39
4009719-2	1985	Oxygen equilibrium measurements of stripped hemoglobin Alberta at 20 degrees C in the absence of phosphate revealed a high affinity (P50 = 0.75 mm Hg at pH 7), co-operative hemoglobin variant (n = 2.3 at pH 7) with a normal Bohr effect (- delta log P50/delta pH(7-8) = 0.65).	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	249-258
3890484-0	1985	Leucocytes activated by C5a des Arg promote endothelial prostacyclin (PGI2) production via release of oxygen species in vitro.	Oxygen	102-108	complement C5a receptor 1	Homo sapiens	24-27
4008144-10	1985	Lactate levels (+30%) as well as noradrenaline and adrenaline responses (+60%-90%) were higher in the cumulative experiment (test 1) at work loads corresponding to 70%-80% of the oxygen uptake capacity as compared to the noncumulative testing procedure (test 2).	Oxygen	179-185	serine protease 21	Homo sapiens	125-131
3988004-8	1985	Considering our previous data indicating that TCE did not stimulate mitochondrial respiration, it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome P-450 than the amount which was necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system.	Oxygen	142-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	205-221
2981925-3	1985	Neutrophils and other phagocytes can injure cells by means of oxygen-dependent mechanisms, particularly the myeloperoxidase (MPO)-H2O2-halide system.	Oxygen	62-68	myeloperoxidase	Homo sapiens	108-123
4029180-5	1985	During ET1, ARCR decreased (from 1.53 +/- 0.43 to 1.04 +/- 0.35 mmHg ml-1 min-1, P less than 0.001) as a result of the metabolic vasodilation, while it rose, although non significantly, during CPT despite the increase in double product (P less than 0.001), reflecting the augmented myocardial oxygen consumption.	Oxygen	293-299	endothelin 1	Homo sapiens	7-10
2981925-3	1985	Neutrophils and other phagocytes can injure cells by means of oxygen-dependent mechanisms, particularly the myeloperoxidase (MPO)-H2O2-halide system.	Oxygen	62-68	myeloperoxidase	Homo sapiens	125-128
2981929-7	1985	Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone.	Oxygen	11-17	interferon gamma	Homo sapiens	148-157
2981929-7	1985	Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone.	Oxygen	11-17	interferon gamma	Homo sapiens	219-228
4013446-0	1985	[Changes in erythrocyte P50 and its effect on O2 transport in intravenous tocolysis with fenoterol (Partusisten)].	Oxygen	46-48	nuclear factor kappa B subunit 1	Homo sapiens	24-27
2981929-7	1985	Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone.	Oxygen	59-65	interferon gamma	Homo sapiens	148-157
2981929-7	1985	Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone.	Oxygen	59-65	interferon gamma	Homo sapiens	219-228
2991464-1	1985	The reaction of a reduced cytochrome oxidase system consisting of beef heart cytochrome oxidase, cytochrome c, and ascorbate with molecular oxygen was kinetically and thermodynamically investigated using a stopped-flow, rapid wavelength-scanning technique.	Oxygen	140-146	cytochrome c, somatic	Homo sapiens	97-109
2988006-3	1985	The data obtained prompt an assumption that the increase in the rate of O2- generation is perhaps connected with the changes in functioning of both NADPH-cytochrome P-450-reductase and cytochrome P-450.	Oxygen	72-74	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	154-170
3838366-1	1985	The glycoprotein hormone erythropoietin regulates the level of oxygen in the blood by modulating the number of circulating erythrocytes, and is produced in the kidney or liver of adult and the liver of fetal or neonatal mammals.	Oxygen	63-69	erythropoietin	Homo sapiens	25-39
2988200-1	1985	In the particles enriched with plasmatic membranes of target cells (human erythrocytes, skeletal muscles and adipocytes of rats) ATP was steadily formed within 1 min of incubation of the particles with insulin (4 microgram/ml) in the medium containing Tris-HCl buffer, pH 7.5, ADP, Mg2+, inorganic phosphate, NaF, during NADH oxidation in presence of cytochrome c and oxygen (30 degrees).	Oxygen	368-374	insulin	Homo sapiens	202-209
3884574-1	1985	Systemic administration of angiotensin II (ANG II) (200 micrograms/kg sc) to the rat induced a hypothermic response that was characterized within 12 min by a reduction in the rate of O2 consumption, vasodilation of the tail, and a 1.3 degrees C fall in colonic temperature.	Oxygen	183-185	angiotensinogen	Rattus norvegicus	27-41
2983703-2	1985	The antioxidants CuZn-superoxide dismutase, catalase, glutathione peroxidase and butylated-hydroxytoluene inhibit the reaction indicating that active oxygen species produced in the PMA-induced oxidative burst represent intermediates.	Oxygen	150-156	catalase	Homo sapiens	44-52
16346737-0	1985	Quantitative addition of dissolved oxygen to in situ benthic chamber systems by use of catalase and hydrogen peroxide.	Oxygen	35-41	catalase	Homo sapiens	87-95
2981610-0	1985	Role of active oxygen species in the photodestruction of microsomal cytochrome P-450 and associated monooxygenases by hematoporphyrin derivative in rats.	Oxygen	15-21	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
2981610-5	1985	The destruction of cytochrome P-450 was a photodynamic process requiring oxygen since quenchers of singlet oxygen, including 2,5-dimethylfuran, histidine, and beta-carotene, each substantially diminished the reaction.	Oxygen	73-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35
3156149-6	1985	Plasmin blocked the thrombin-induced release of [3H]arachidonic acid from platelet membrane phospholipids and the thrombin-induced platelet oxygen burst.	Oxygen	140-146	coagulation factor II, thrombin	Homo sapiens	114-122
3884574-1	1985	Systemic administration of angiotensin II (ANG II) (200 micrograms/kg sc) to the rat induced a hypothermic response that was characterized within 12 min by a reduction in the rate of O2 consumption, vasodilation of the tail, and a 1.3 degrees C fall in colonic temperature.	Oxygen	183-185	angiotensinogen	Rattus norvegicus	43-49
3989752-4	1985	The same pattern was seen in macrophages treated with catalase, an inhibitor of the oxygen-dependent killing mechanism of the macrophage.	Oxygen	84-90	catalase	Mus musculus	54-62
2579663-0	1985	The whole blood oxygen affinity in normal human newborns: II) P50, n value and related parameters.	Oxygen	16-22	nuclear factor kappa B subunit 1	Homo sapiens	62-65
3966198-2	1985	In addition, the percentage oxygen saturation of the cord blood was inversely correlated with cord blood C-peptide levels and with the relative BWR.	Oxygen	28-34	insulin	Homo sapiens	105-114
2982205-3	1985	Normally intracellular enzyme systems that include superoxide dismutase, catalase, and glutathione peroxidase are responsible for "scavenging" these products of oxygen metabolism.	Oxygen	161-167	catalase	Homo sapiens	73-81
2983796-4	1985	A mixture of oxygen metabolite scavengers (superoxide dismutase, catalase and mannitol) eliminated the relaxation induced by the xanthine oxidase products.	Oxygen	13-19	catalase	Oryctolagus cuniculus	65-73
3916400-0	1985	Clarification of the effects of changes in P50 on oxygen transport.	Oxygen	50-56	nuclear factor kappa B subunit 1	Homo sapiens	43-46
4040372-5	1985	The time-course of this decrease suggests that acute ethanol administration affects primarily extra-peroxisomal catalase activity, thus rendering cytosolic superoxide dismutase more exposed to oxygen derivatives.	Oxygen	193-199	catalase	Rattus norvegicus	112-120
3917634-3	1985	Nine patients received oxygen for 24 h, and 5 received oxygen for 72 h. In these 5 patients, oxygen supplementation resulted in a shift in P50 to a normal value of 26.7 +/- 1.8 (this value was different from the patients" level while breathing room air and not different from that of the normoxemic control subjects) and a decrease in 2,3-DPG toward but not to a normal value (16.34 +/- 1.92; p less than 0.01).	Oxygen	55-61	nuclear factor kappa B subunit 1	Homo sapiens	139-142
3917634-3	1985	Nine patients received oxygen for 24 h, and 5 received oxygen for 72 h. In these 5 patients, oxygen supplementation resulted in a shift in P50 to a normal value of 26.7 +/- 1.8 (this value was different from the patients" level while breathing room air and not different from that of the normoxemic control subjects) and a decrease in 2,3-DPG toward but not to a normal value (16.34 +/- 1.92; p less than 0.01).	Oxygen	55-61	nuclear factor kappa B subunit 1	Homo sapiens	139-142
3890847-5	1985	The formation of the cytochrome P-450-reductase-complex necessary for oxygen activation by transfer of electrons is dependent on the charge of the phospholipids.	Oxygen	70-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-37
3830285-2	1985	Oxygen consumption (ml min-1 m-2) increased from 149 to 224 during C, from 160 to 196 during HL, from 154 to 178 during HP, and from 166 to 187 during HL.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	23-28
3996046-4	1985	Oxygen consumption per cell was 0.244 +/- 0.02 mumol min-1 per 10(8) cells and the enthalpy change was -836 kJ/mol O2.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
4042454-1	1985	Four-day-old artificial pulmonary micrometastases of two murine fibrosarcomas, designated FSA and NFSA, showed increased sensitivity to ionizing radiation by a factor of 1.13 when animals were exposed to hyperbaric oxygen breathing before and during irradiation, implying the presence of hypoxia in the micrometastases.	Oxygen	215-221	RIKEN cDNA 4932438A13 gene	Mus musculus	90-93
4042454-2	1985	At the time of irradiation the diameter of FSA and NFSA metastases was smaller than 200 and 100 microns, respectively, which, on the basis of oxygen diffusion, could not be responsible for hypoxia.	Oxygen	142-148	RIKEN cDNA 4932438A13 gene	Mus musculus	43-46
3930241-4	1985	Compared to the smokeless trials, the passive inhalation of smoke significantly reduced maximal oxygen uptake by 0.25 l X min-1 and time to exhaustion by 2.1 min.	Oxygen	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	122-127
2982673-1	1985	Experimental study in 156 white rats with renovascular hypertension, posthemorrhagic hypotension and with normal blood pressure revealed that high--ressure oxygen (303.9 kPa--50 min) could activate angiotensin--converting enzyme, the latter taking part in inactivation of endogenous opioid peptides.	Oxygen	156-162	angiotensin I converting enzyme	Rattus norvegicus	198-228
4039258-1	1985	The effect of a progressively increasing work rate (15 W X min-1) up to exhaustion on the time course of O2 uptake (VO2), ventilation (VE) and heart rate (HR) has been studied in weight lifters (WL) in comparison to endurance cyclists (Cycl) and sedentary controls (Sed).	Oxygen	105-107	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
3968295-16	1985	min-1 a significant increase in stroke volume, mixed venous oxygen tension and decrease in right atrial pressure and systemic vascular resistance was also observed.	Oxygen	60-66	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
4019017-6	1985	Maximal oxygen consumption (VO2 max, m10(2)/kg X min-1) predicted from the Bruce Test increased by 0.08 +/- 7, 9 +/- 12 and 12 +/- 9 percent in groups C, D and P, respectively.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
3859465-7	1985	Our data are in conflict with previous claims that Hb OArab mixtures with Hb S polymerized almost as much as pure S. Oxygen association curves show a significant displacement of the p50 to the right, but the effect of oxygen dissociation is less apparent.	Oxygen	117-123	nuclear factor kappa B subunit 1	Homo sapiens	182-185
3934096-2	1985	Flunarizine inhibited FMLP- and A23187-induced aggregation, enzyme release and O2- generation from human PMN as a function of its concentration.	Oxygen	79-81	formyl peptide receptor 1	Homo sapiens	22-26
3934096-6	1985	Nifedipine, another Ca++-entry blocker, was shown to inhibit enzyme release and O2- generation induced by FMLP and A23187 as a function of its concentration, but only slightly affected PMN aggregation at very high concentration (10(-4)M).	Oxygen	80-82	formyl peptide receptor 1	Homo sapiens	106-110
3968295-19	1985	min-1 a significant increase in pulse rate, mean arterial blood pressure mean pulmonary blood pressure, right ventricular stroke work index, right atrial pressure and pulmonary arterial occlusion pressure and decrease in arterial oxygen tension was also observed.	Oxygen	230-236	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
3018063-2	1985	The pyridine cofactors NADPH and NADH, riboflavin, and the nucleosides 2-thiouracil and 4-thiouridine were found to sensitize the transmission of photon energy from solar radiation and monochromatic radiation (290, 334, 365, and 405 nm) to oxygen, resulting in O2- formation, as detected by superoxide dismutase-inhibitable cytochrome c reduction.	Oxygen	240-246	cytochrome c, somatic	Homo sapiens	324-336
3915305-6	1985	The induction of catalase to eliminate hydrogen peroxide appears to be an important response of these thermophilic bacteria to oxygen toxicity.	Oxygen	127-133	catalase	Homo sapiens	17-25
2933619-2	1985	Catalase is a scavenger of hydrogen peroxide and presumably protects against the cytolytic effects of reactive oxygen metabolites.	Oxygen	111-117	catalase	Homo sapiens	0-8
24272514-3	1985	A comparison of the results with different methods demonstrates the reliability of the Lex-O2 in the determination of oxygen dissolved in heterogeneous or non-aqueous systems.	Oxygen	118-124	fucosyltransferase 4	Homo sapiens	87-90
3161101-6	1985	Oxygen consumption was measured with a Clark"s oxygen electrode and respiration was expressed in nAt oxygen per min per mg protein, which was measured by the method of Lowry et al.	Oxygen	101-107	N-acetyltransferase 1	Rattus norvegicus	97-100
3880802-6	1985	The activity of pulmonary angiotensin-converting enzyme (ACE) has been reported to be affected by oxygen tension, and ACE degrades bradykinin, a proinflammatory mediator.	Oxygen	98-104	angiotensin I converting enzyme	Rattus norvegicus	57-60
4058620-6	1985	Consequently, the location of an oxygen sensor in the kidneys controlling erythropoietin production appears to be most fortuitous since it prevents the development of a vicious circle, with erythrocytosis causing more erythrocytosis.	Oxygen	33-39	erythropoietin	Homo sapiens	74-88
24272514-2	1985	The Lex-O2-Content Analyzer represents a fast and simple apparatus that employs a coulometric oxygen assay with Hersch cell detection.	Oxygen	94-100	fucosyltransferase 4	Homo sapiens	4-7
3936170-13	1985	An evaluation of one of these new-generation membrane oxygenators gave optimal oxygen and carbon dioxide exchange at a gas flow of 1 l/min of 60% oxygen in air at 30 degrees C and 2 l/min of 80% oxygen in air at normal temperature and rewarming for an adult.	Oxygen	54-60	cullin associated and neddylation dissociated 2 (putative)	Homo sapiens	174-181
3018063-2	1985	The pyridine cofactors NADPH and NADH, riboflavin, and the nucleosides 2-thiouracil and 4-thiouridine were found to sensitize the transmission of photon energy from solar radiation and monochromatic radiation (290, 334, 365, and 405 nm) to oxygen, resulting in O2- formation, as detected by superoxide dismutase-inhibitable cytochrome c reduction.	Oxygen	261-263	cytochrome c, somatic	Homo sapiens	324-336
6511912-10	1984	Experiments were carried out using rat liver microsomes to examine the effect of O2 tensions found in the liver and of GSH on CCl4-induced covalent binding and lipid peroxidation.	Oxygen	81-83	C-C motif chemokine ligand 4	Rattus norvegicus	126-130
6084519-1	1984	In the presence of NADPH and O2, NADPH-cytochrome P-450 reductase was found to activate Fe(III)-bleomycin A2 for DNA strand scission.	Oxygen	29-31	cytochrome p450 oxidoreductase	Homo sapiens	33-65
6511542-0	1984	Liposome-mediated augmentation of brain SOD and catalase inhibits CNS O2 toxicity.	Oxygen	70-72	catalase	Rattus norvegicus	48-56
6511542-1	1984	Enzymes specific for O-2 and H2O2 metabolism [superoxide dismutase (SOD) and catalase] can be delivered to the rat brain following entrapment in liposomes and intravenous injection and will protect against hyperbaric O2-induced convulsions in rats.	Oxygen	31-33	catalase	Rattus norvegicus	77-85
6511542-3	1984	Rats treated with liposomes containing superoxide dismutase plus catalase 2 h before 6 ATA 100% O2 exposure had the time to convulsion extended three times that of controls.	Oxygen	96-98	catalase	Rattus norvegicus	65-73
6511912-17	1984	These results indicate that low O2 tensions such as are found in the centrilobular areas of the liver favor conversion of CCl4 to free radical products which cannot be detoxified by the GSH-dependent mechanism.	Oxygen	32-34	C-C motif chemokine ligand 4	Rattus norvegicus	122-126
6511912-23	1984	This strongly suggests that hyperbaric O2 is decreasing free radical formation from CCl4 and/or promoting the formation of CCl(3)00. from CCl3..	Oxygen	39-41	C-C motif chemokine ligand 4	Rattus norvegicus	84-88
6511912-24	1984	These results provide the rationale for the use of hyperbaric O2 in the treatment of CCl4 ingestion.	Oxygen	62-64	C-C motif chemokine ligand 4	Rattus norvegicus	85-89
6528109-2	1984	The in vivo oxygen partial pressure at 50% oxygen hemoglobin saturation (P50) decreased from 37.4 +/- 2.1 to 12.7 +/- 0.7 mm Hg; the arterial oxygen tension was reduced significantly from 109.9 +/- 7.7 to 87.3 +/- 12.0 mm Hg.	Oxygen	12-18	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6527532-6	1984	The presence of multiple oxygen functions on C21 steroids, as in cortisol and corticosterone, precludes interaction.	Oxygen	25-31	TBL1X/Y related 1	Homo sapiens	45-48
6096874-0	1984	Base (O.-2, e-, or OH-)-induced autoxygenation of organic substrates: a model chemical system for cytochrome P-450-catalyzed monoxygenation and dehydrogenation by dioxygen.	Oxygen	163-171	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-114
6528109-2	1984	The in vivo oxygen partial pressure at 50% oxygen hemoglobin saturation (P50) decreased from 37.4 +/- 2.1 to 12.7 +/- 0.7 mm Hg; the arterial oxygen tension was reduced significantly from 109.9 +/- 7.7 to 87.3 +/- 12.0 mm Hg.	Oxygen	43-49	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6528109-2	1984	The in vivo oxygen partial pressure at 50% oxygen hemoglobin saturation (P50) decreased from 37.4 +/- 2.1 to 12.7 +/- 0.7 mm Hg; the arterial oxygen tension was reduced significantly from 109.9 +/- 7.7 to 87.3 +/- 12.0 mm Hg.	Oxygen	43-49	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6093188-12	1984	Superoxide dismutase (SOD) was found to stimulate the oxygen uptake in the case of MEA and cysteine, but had little or no effect with DTT and glutathione.	Oxygen	54-60	superoxide dismutase 1	Homo sapiens	0-20
6496394-5	1984	min-1) on power output (W), which reflects the rate of increase in energy expended relative to increases in external work performed, did not differ significantly between the fed and fasting conditions for either group, but the mean (+/- SEM) intercept was significantly higher for the normal, but not the obese men, in the fed than the fasting state (599 +/- 53 versus 497 +/- 47 ml O2 .	Oxygen	383-385	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
6436189-5	1984	Catalase reduced the corneal swelling caused by exposure of endothelium to the oxygen-free radical generating system, whereas superoxide dismutase, ascorbic acid, D-mannitol, and ethanol did not prevent damage.	Oxygen	79-85	catalase	Homo sapiens	0-8
6502312-3	1984	The magnitude of the erythropoietin response inversely varied with the central venous oxygen tension (P-vO2) (r = -0.55, P less than 0.001).	Oxygen	86-92	erythropoietin	Homo sapiens	21-35
6502313-0	1984	Decreased response of plasma immunoreactive erythropoietin to "available oxygen" in anemia of prematurity.	Oxygen	73-79	erythropoietin	Homo sapiens	44-58
6502313-2	1984	In the adults, "available oxygen" (derived from oxygen carrying capacity and P50) averaged 13.1 ml/dl blood and the mean erythropoietin level was 15.2 mU/ml.	Oxygen	26-32	nuclear factor kappa B subunit 1	Homo sapiens	77-80
6502313-3	1984	Erythropoietin levels in the infants were inversely related to concentration of hemoglobin, P50, and available oxygen.	Oxygen	111-117	erythropoietin	Homo sapiens	0-14
6502313-5	1984	Furthermore, the erythropoietin response to decreased "available oxygen" was lowest in the least mature infants.	Oxygen	65-71	erythropoietin	Homo sapiens	17-31
6502313-7	1984	The relatively low erythropoietin levels in relation to "available oxygen" are compatible with a decreased erythropoietin response to hypoxia compared with that in adults.	Oxygen	67-73	erythropoietin	Homo sapiens	19-33
6502313-7	1984	The relatively low erythropoietin levels in relation to "available oxygen" are compatible with a decreased erythropoietin response to hypoxia compared with that in adults.	Oxygen	67-73	erythropoietin	Homo sapiens	107-121
6505989-7	1984	The mean slope of the relationship between KCO and oxygen consumption (VO2) was steeper in women than in men (mean slopes 0.627 and 0.348 mmol min-1 kPa-1 l-1 per 1 min-1 respectively), and the same was true for the relationship between KCO and work rate.	Oxygen	51-57	CD59 molecule (CD59 blood group)	Homo sapiens	165-170
6208195-3	1984	The monooxygenase is dependent upon NADPH plus oxygen, insensitive to CN-, and sensitive to CO. Microsomal oxidation is also sensitive to trypsin digestion, and reactivation is dependent upon the addition of purified, detergent-solubilized cytochrome P-450 reductase.	Oxygen	8-14	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	240-256
6439182-5	1984	Alveolar PCO2 on the summit was 7.5 mm Hg, the arterial pH and PO2 were calculated to be over 7.7 and less than 30 mm Hg, respectively, and maximum oxygen uptake was about 1 L X min-1.	Oxygen	148-154	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
6096396-0	1984	Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	74-94
6093188-10	1984	Catalase also reduces the oxygen uptake for all thiols.	Oxygen	26-32	catalase	Homo sapiens	0-8
6093188-12	1984	Superoxide dismutase (SOD) was found to stimulate the oxygen uptake in the case of MEA and cysteine, but had little or no effect with DTT and glutathione.	Oxygen	54-60	superoxide dismutase 1	Homo sapiens	22-25
6093188-13	1984	The combined presence of SOD and catalase resulted in less inhibition of oxygen uptake than that obtained by catalase alone.	Oxygen	73-79	superoxide dismutase 1	Homo sapiens	25-28
6093188-13	1984	The combined presence of SOD and catalase resulted in less inhibition of oxygen uptake than that obtained by catalase alone.	Oxygen	73-79	catalase	Homo sapiens	33-41
6093188-13	1984	The combined presence of SOD and catalase resulted in less inhibition of oxygen uptake than that obtained by catalase alone.	Oxygen	73-79	catalase	Homo sapiens	109-117
6088156-7	1984	The reduction in ACE activity was greater in the good acclimatizer group as shown by a significantly greater slope of the response line of ACE activity to arterial oxygen saturation.	Oxygen	164-170	angiotensin I converting enzyme	Homo sapiens	17-20
6435889-3	1984	Macrophage oxygen metabolism could also be induced by a L. monocytogenes-specific T-cell clone which was recently shown to mediate anti-listerial protection in vivo and to secrete interferon-gamma (IFN-gamma) in vitro.	Oxygen	11-17	interferon gamma	Mus musculus	198-207
6435889-5	1984	It is concluded that acquired resistance to facultative intracellular pathogens--at least in part--depends on the activation of macrophage oxygen metabolism by IFN-gamma derived from specific Lyt 1+2,3- T cells.	Oxygen	139-145	interferon gamma	Mus musculus	160-169
6089934-3	1984	Superoxide (O2-) production by stimulated PMNs was assessed by the superoxide dismutase-inhibitable reduction of cytochrome c.	Oxygen	12-14	cytochrome c, somatic	Homo sapiens	113-125
6089934-6	1984	In contrast, LTB4-treated cells demonstrated enhanced O2- production following exposure to fMLP, and in the presence of 10 nmol/LLTB4, generated 180% +/- 41% of O-2 quantities produced by control cells (n = 23).	Oxygen	54-56	formyl peptide receptor 1	Homo sapiens	91-95
6088156-7	1984	The reduction in ACE activity was greater in the good acclimatizer group as shown by a significantly greater slope of the response line of ACE activity to arterial oxygen saturation.	Oxygen	164-170	angiotensin I converting enzyme	Homo sapiens	139-142
6494425-1	1984	CuZn superoxide dismutase, Mn superoxide dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic oxygen reduction metabolites in cells.	Oxygen	136-142	superoxide dismutase 1	Homo sapiens	0-25
6385009-2	1984	While many of these are known to be induced in the presence of oxygen, we have described a gene, ANB1, that responds in the opposite fashion, being expressed only under anaerobic conditions.	Oxygen	63-69	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	97-101
6385009-3	1984	To identify genes involved in regulation of ANB1 and other oxygen-regulated genes, we selected mutations causing constitutive expression of ANB1, using a fusion of the ANB1 modulator segment to the CYC1 gene.	Oxygen	59-65	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	140-144
6385009-3	1984	To identify genes involved in regulation of ANB1 and other oxygen-regulated genes, we selected mutations causing constitutive expression of ANB1, using a fusion of the ANB1 modulator segment to the CYC1 gene.	Oxygen	59-65	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	140-144
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	80-86	Rox1p	Saccharomyces cerevisiae S288C	12-16
6090316-4	1984	The oxygen-dependent brucellacidal activity of granule extracts was dependent on concentrations of myeloperoxidase (MPO) units, H2O2, and KI.	Oxygen	4-10	myeloperoxidase	Homo sapiens	99-114
6090316-4	1984	The oxygen-dependent brucellacidal activity of granule extracts was dependent on concentrations of myeloperoxidase (MPO) units, H2O2, and KI.	Oxygen	4-10	myeloperoxidase	Homo sapiens	116-119
6487320-1	1984	A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions.	Oxygen	244-246	myeloperoxidase	Homo sapiens	220-235
6487320-1	1984	A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions.	Oxygen	244-246	myeloperoxidase	Homo sapiens	237-240
6487320-3	1984	Consequently the MPO-H2O2-halide system could be distinguished from the O2- dependent system by interpreting the recorded temporal traces of the emitted light.	Oxygen	23-25	myeloperoxidase	Homo sapiens	17-20
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	80-86	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	186-190
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	80-86	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	252-256
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	Rox1p	Saccharomyces cerevisiae S288C	12-16
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	186-190
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	252-256
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	Rox1p	Saccharomyces cerevisiae S288C	12-16
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	186-190
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	149-155	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	252-256
6385009-9	1984	The pleiotropy of the rox1-a1 mutant indicates that the ROX1 gene product is involved in coordinate expression of both oxygen-induced and oxygen-repressed genes.	Oxygen	119-125	Rox1p	Saccharomyces cerevisiae S288C	22-26
6385009-9	1984	The pleiotropy of the rox1-a1 mutant indicates that the ROX1 gene product is involved in coordinate expression of both oxygen-induced and oxygen-repressed genes.	Oxygen	119-125	Rox1p	Saccharomyces cerevisiae S288C	56-60
6385009-9	1984	The pleiotropy of the rox1-a1 mutant indicates that the ROX1 gene product is involved in coordinate expression of both oxygen-induced and oxygen-repressed genes.	Oxygen	138-144	Rox1p	Saccharomyces cerevisiae S288C	22-26
6385009-9	1984	The pleiotropy of the rox1-a1 mutant indicates that the ROX1 gene product is involved in coordinate expression of both oxygen-induced and oxygen-repressed genes.	Oxygen	138-144	Rox1p	Saccharomyces cerevisiae S288C	56-60
6525302-1	1984	Actual determination of the position of the oxygen hemoglobin dissociation curve (P50) was compared to three methods of estimating P50 in 39 patients with various diseases.	Oxygen	44-50	nuclear factor kappa B subunit 1	Homo sapiens	82-85
6477950-3	1984	Under these conditions, at the hypoxic end of the physiological PO2 in liver, CCl4 caused a 5-fold increase in the oxygen uptake rate and a 20-fold increase in the malondialdehyde formation rate while, at 80 mmHg (10.7 kPa) the haloalkane caused only an increase of 2- and 4-fold, respectively; in comparison, there was only a slight increase in NADPH-induced lipid peroxidation with increasing PO2.	Oxygen	115-121	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
6088104-4	1984	Thus, intracellular oxidation by activated oxygen likely represents the source of endogenously formed NO3- in mammals.	Oxygen	43-49	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
6206897-0	1984	Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu----Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn.	Oxygen	75-81	tryptophanyl-tRNA synthetase 1	Homo sapiens	26-33
6089627-0	1984	Hypoxia preadaptation prevents oxygen-induced depression of lung angiotensin-converting enzyme activity.	Oxygen	31-37	angiotensin I converting enzyme	Rattus norvegicus	65-94
6091557-0	1984	Redox state of cytochrome c in the presence of the 6-hydroxydopamine/oxygen couple: oscillations dependent on the presence of hydrogen peroxide or superoxide.	Oxygen	69-75	cytochrome c, somatic	Homo sapiens	15-27
6487942-2	1984	The cyclist covered a distance of 694 km during the event at an average speed of 28.9 km.h-1 which corresponded to an equivalent oxygen cost of 38.5 ml.kg-1 min-1 and represented approximately 55% of his VO2 max.	Oxygen	129-135	CD59 molecule (CD59 blood group)	Homo sapiens	157-162
6548844-8	1984	These results show that the chief active oxygen to cause cell damage is H2O2 and the scavenger antioxidants in the serum are hemoglobin and catalase.	Oxygen	41-47	catalase	Homo sapiens	140-148
6498626-4	1984	Low Ca2+ perfusion was associated with reduction in the heart rate--left ventricular systolic pressure product and O2 consumption, tendency for the coronary sinus flow to increase, electromechanical dissociation, prolongation of atrioventricular conduction and QT interval, and decrease in myocardial glycogen.	Oxygen	115-117	carbonic anhydrase 2	Oryctolagus cuniculus	4-7
6431003-2	1984	We report that the intraerythrocytic parasite P. falciparum is lethally susceptible to the imposition of oxygen-dependent and oxygen-independent factor(s) released by interferon-gamma-activated, monocyte-derived human macrophages.	Oxygen	105-111	interferon gamma	Homo sapiens	167-183
6431003-2	1984	We report that the intraerythrocytic parasite P. falciparum is lethally susceptible to the imposition of oxygen-dependent and oxygen-independent factor(s) released by interferon-gamma-activated, monocyte-derived human macrophages.	Oxygen	126-132	interferon gamma	Homo sapiens	167-183
6431003-11	1984	A role for oxygen-independent parasiticidal factors was suggested by the finding that lymphokine-activated macrophages from a patient with chronic granulomatous disease were able to partially inhibit the growth of P. falciparum, although oxidative metabolism in these cells was impaired.	Oxygen	11-17	interleukin 2	Homo sapiens	86-96
6515058-0	1984	[60Co-gamma-radiolysis of C18 unsaturated fatty acid methyl esters in an oxygen free state].	Oxygen	73-79	Bardet-Biedl syndrome 9	Homo sapiens	26-29
6088517-1	1984	Oxidized cytochrome c oxidase in a carbon monoxide atmosphere slowly becomes reduced as shown by changes in its visible spectra and its reactivity toward oxygen.	Oxygen	154-160	cytochrome c, somatic	Homo sapiens	9-21
6088517-9	1984	However, when the CO-driven reduction of cytochrome c oxidase occurs in the presence of oxygen, there is a competition between CO and oxygen for the reduced heme and copper of cytochrome alpha 3.	Oxygen	88-94	cytochrome c, somatic	Homo sapiens	41-53
6088517-9	1984	However, when the CO-driven reduction of cytochrome c oxidase occurs in the presence of oxygen, there is a competition between CO and oxygen for the reduced heme and copper of cytochrome alpha 3.	Oxygen	134-140	cytochrome c, somatic	Homo sapiens	41-53
6738642-0	1984	Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle-cell anemia.	Oxygen	11-17	erythropoietin	Homo sapiens	43-57
6738642-2	1984	When three patients with sickle-cell anemia who were not in crisis or infected breathed oxygen at a rate of 5 liters per minute continuously through nasal prongs for five days, there was a rapid decline in erythropoietin levels that had initially been elevated, a delayed fall in the number of reticulocytes, and a fall in the number of irreversibly sickled cells, which, in two of the subjects, preceded the suppression of reticulocytosis.	Oxygen	88-94	erythropoietin	Homo sapiens	206-220
6738642-3	1984	After cessation of oxygen therapy, erythropoietin levels and the number of irreversibly sickled cells increased promptly, followed by an increase in the number of reticulocytes.	Oxygen	19-25	erythropoietin	Homo sapiens	35-49
6086177-5	1984	The use of superoxide dismutase and catalase satisfactorily prevented the oxygen-induced injury.	Oxygen	74-80	catalase	Oryctolagus cuniculus	36-44
6431044-8	1984	When P50 was elevated, the cardiac index at high work load was lower than when P50 was normal (with comparable O2 consumption); changes in P50 correlated inversely with changes in cardiac index.	Oxygen	111-113	nuclear factor kappa B subunit 1	Homo sapiens	5-8
6087808-0	1984	Myeloperoxidase singlet molecular oxygen generation detected by direct infrared electronic emission.	Oxygen	34-40	myeloperoxidase	Homo sapiens	0-15
6725272-2	1984	This laboratory has recently reported that, in a reconstituted enzyme system containing alcohol-induced isozyme 3a of liver microsomal cytochrome P-450, the sum of acetaldehyde generated by the monooxygenation of ethanol and of hydrogen peroxide produced by the NADPH oxidase activity is inadequate to account for the O2 and NADPH consumed.	Oxygen	318-320	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-151
6742038-5	1984	We speculate that the increase in erythropoietin levels during pregnancy acts as a trophic stimulus for effecting an increase in maternal red blood cell mass presumably to meet the increased metabolic (oxygen) demands of pregnancy.	Oxygen	202-208	erythropoietin	Homo sapiens	34-48
6205248-0	1984	The interaction of the phosphorothioate insecticides chlorpyrifos and parathion and their oxygen analogues with bovine serum albumin.	Oxygen	90-96	albumin	Homo sapiens	119-132
17005145-2	1984	There was a decrease in the oxygen bimolecular quenching constant upon complexation of trypsin and alpha-chymotrypsin with proteinaceous trypsin inhibitors, of lysozyme with N-acetylglucosamine (NAG) and di(N-acetyl-D-glucosamine) ((NAG)2) and of hexokinase with glucose.	Oxygen	28-34	hexokinase 1	Homo sapiens	247-257
6731907-8	1984	Similar hypoxia and hypercapnia caused by breathing 9% O2 and 8% CO2 in the absence of morphine caused plasma BSP clearance to be decreased to 4.4 +/- 0.2 ml X min-1 and 40-min hepatic BSP to be increased to 292.5 +/- 31.8 micrograms X g-1.	Oxygen	55-57	integrin-binding sialoprotein	Rattus norvegicus	110-113
6373455-4	1984	A significant correlation also existed between insulin action and response in these subjects (r = 0.67, P less than 0.001), which remained significant (r = 0.65) when differences in total glucose response, obesity, age, and maximal oxygen consumption were taken into account.	Oxygen	232-238	insulin	Homo sapiens	47-54
6539095-5	1984	With ferric leghemoglobin (Lb) as the substrate, nearly identical initial velocities were obtained using either CO or O2 to ligate the enzymatically produced ferrous leghemoglobin.	Oxygen	118-120	leghemoglobin A	Glycine max	166-179
6733835-4	1984	Maximal oxygen uptake average 5.09 l X min-1, or 76.0 ml X kg-1 X min-1, for the males, and 3.59 l X min-1, or 68.0 ml X kg-1 X min-1, for the females.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
6733835-4	1984	Maximal oxygen uptake average 5.09 l X min-1, or 76.0 ml X kg-1 X min-1, for the males, and 3.59 l X min-1, or 68.0 ml X kg-1 X min-1, for the females.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
6733835-4	1984	Maximal oxygen uptake average 5.09 l X min-1, or 76.0 ml X kg-1 X min-1, for the males, and 3.59 l X min-1, or 68.0 ml X kg-1 X min-1, for the females.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
6733835-4	1984	Maximal oxygen uptake average 5.09 l X min-1, or 76.0 ml X kg-1 X min-1, for the males, and 3.59 l X min-1, or 68.0 ml X kg-1 X min-1, for the females.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
6204963-5	1984	When mice were exposed to 75% O2, the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced.	Oxygen	30-32	catalase	Mus musculus	74-82
6204963-5	1984	When mice were exposed to 75% O2, the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced.	Oxygen	183-189	catalase	Mus musculus	74-82
6587349-0	1984	Epoxidation of olefins by cytochrome P-450 model compounds: mechanism of oxygen atom transfer.	Oxygen	73-79	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-42
6734809-2	1984	Animals receiving no-spa demonstrated a substantial increase in oxygen partial tension and saturation of venous blood hemoglobin with oxygen.	Oxygen	64-70	surfactant protein A1	Rattus norvegicus	21-24
6734809-2	1984	Animals receiving no-spa demonstrated a substantial increase in oxygen partial tension and saturation of venous blood hemoglobin with oxygen.	Oxygen	134-140	surfactant protein A1	Rattus norvegicus	21-24
6330372-3	1984	Cellular injuries induced by reoxygenation, "Oxygen paradox", were partially prevented by scavengers of H2O2 (glutathione reduced form, catalase) and O-2 (superoxide dismutase).	Oxygen	45-51	catalase	Homo sapiens	136-144
6372787-2	1984	In mouse pancreatic islets the kinetics of insulin secretion and O2 uptake in response to the non-metabolizable leucine analogue (+/-)-BCH (2-endo- aminonorbornane -2-carboxylic acid) were compared.	Oxygen	65-67	chimerin 2	Mus musculus	135-138
6706998-3	1984	The inhibition rate constant for the scavenging of peroxy radical was calculated at 37 degrees C as kinh = 5.1 X 10(5) M-1 s-1 and 7.5 X 10(4) M-1 s-1 for vitamin E and vitamin C, respectively.	Oxygen	51-65	tumor associated calcium signal transducer 2	Homo sapiens	119-150
6372787-4	1984	(1) Within 2 min 20 mM-(+/-)-BCH markedly enhanced insulin release or O2 consumption by islets respiring in the absence of exogenous fuels.	Oxygen	70-72	chimerin 2	Mus musculus	29-32
6372787-6	1984	(2) L-Glutamine (10 mM) prevented the decrease of both insulin release and O2 uptake of islets exposed to 20mM-(+/-)-BCH.	Oxygen	75-77	chimerin 2	Mus musculus	117-120
6199872-3	1984	Superoxide dismutase (SOD) significantly inhibited bleomycin-mediated DNA deoxyribose cleavage, indicating the involvement of reactive oxygen.	Oxygen	135-141	superoxide dismutase 1	Homo sapiens	0-20
6321594-2	1984	Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism.	Oxygen	20-26	myeloperoxidase	Homo sapiens	37-52
6745813-5	1984	The effects of superoxide dismutase, catalase, NaN3 and L-ascorbic acid on the generation of active oxygen from rat phagocytic cells were different between CL and LDH-NADH methods.	Oxygen	100-106	catalase	Rattus norvegicus	37-45
6700457-1	1984	An 11-year review of 73 cases managed with hyperbaric oxygen.	Oxygen	54-60	DDB1 and CUL4 associated factor 7	Homo sapiens	0-5
6368584-1	1984	After intravenous glucose/insulin infusion there is an increase in oxygen consumption and energy expenditure that has been referred to as thermogenesis.	Oxygen	67-73	insulin	Homo sapiens	26-33
6725073-6	1984	These results suggest that the observed differences between men and women for peak VO2 elicited during arm cranking when expressed in traditional terms (1 X min-1 and ml X kg-1 X min-1) are a function of the size of the contracting muscle mass and are not due to sex-related differences in either O2 delivery or the O2 utilization capacity of the muscle itself.	Oxygen	84-86	CD59 molecule (CD59 blood group)	Homo sapiens	179-184
6462325-4	1984	After treatment with hyperbaric O2, the activity of MS erythrocyte catalase is significantly (P less than 0.01) elevated by 2-6-fold.	Oxygen	32-34	catalase	Homo sapiens	67-75
6609141-9	1984	In contrast to lactate dehydrogenase the degradation of serum albumin is enhanced by oxygen, probably because of its low tryptophan content.	Oxygen	85-91	albumin	Homo sapiens	56-69
6704124-1	1984	Aldehydes RCH2CHO are formed in addition to epoxides and allylic alcohols upon oxidation of the monosubstituted olefins RCH=CH2, styrene and 6-phenoxy-hex-1-ene, either by liver microsomal systems in the presence of NADPH and O2 or C6H5IO, or by iron-porphyrin- C6H5IO model systems.	Oxygen	226-228	karyopherin subunit alpha 1	Homo sapiens	10-14
6199872-3	1984	Superoxide dismutase (SOD) significantly inhibited bleomycin-mediated DNA deoxyribose cleavage, indicating the involvement of reactive oxygen.	Oxygen	135-141	superoxide dismutase 1	Homo sapiens	22-25
6701046-0	1984	Oxygen transport in the intact hypoxic newborn lamb: acute effects of increasing P50.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	81-84
6324852-1	1984	A stoichiometric amount of methylmercuric chloride substantially inhibits cytochrome c oxidase function under steady-state turnover conditions, where the enzyme is using its substrates, cytochrome c and oxygen, rapidly and continuously.	Oxygen	203-209	cytochrome c, somatic	Homo sapiens	74-86
6696534-4	1984	Vasopressin alone reduced cardiac output (-23%) and O2 delivery to the tissues (-25%), increased mean arterial pressure (+20%) and filling pressures of the heart (+136%), reduced portal pressures (-36%) (from 19 +/- 1 to 12 +/- 1 mmHg, mean +/- SEM), hepatic blood flow (-35%) (1.33 +/- 0.2 to 0.87 +/- 0.1 l/min), and renal blood flow (-16%) (0.77 +/- 0.07 to 0.65 +/- 0.05 l/min).	Oxygen	52-54	arginine vasopressin	Homo sapiens	0-11
6325831-9	1984	The results are interpreted to indicate that a decrease in superoxide dismutase activity in the housefly, by diethyldithiocarbamate administration, is compensated by an elevation in reduced glutathione levels and reduction of oxygen consumption, suggesting the existence of alternative free radical defenses in vivo.	Oxygen	226-232	superoxide dismutase	Musca domestica	59-79
6142491-5	1984	Ferritin itself forms most readily from apoferritin, in the presence of dioxygen, from FeII, not FeIII.	Oxygen	72-80	ferritin heavy chain	Equus caballus	40-51
6711262-6	1984	A respiratory quotient (RQ) of 0.8 was used to calculate oxygen consumption (VO2 ml min-1).	Oxygen	57-63	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
6518415-1	1984	The enzymatic activity of endothelium-bound lipoprotein lipase was measured in rat hearts perfused for 1 h at 37 degrees C. Viability parameters such as beating rate, flow rate, aortic pressure, and oxygen consumption were all kept strictly constant during the entire perfusion time.	Oxygen	199-205	lipoprotein lipase	Rattus norvegicus	44-62
6607896-0	1984	The relationship of oxygen uptake to superoxide dismutase and catalase activity in human skeletal muscle.	Oxygen	20-26	catalase	Homo sapiens	62-70
6701046-1	1984	We examined the acute effects of a change in hemoglobin oxygen affinity (P50) on systemic oxygen transport and oxygen consumption during hypoxia.	Oxygen	56-62	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6701046-1	1984	We examined the acute effects of a change in hemoglobin oxygen affinity (P50) on systemic oxygen transport and oxygen consumption during hypoxia.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6701046-1	1984	We examined the acute effects of a change in hemoglobin oxygen affinity (P50) on systemic oxygen transport and oxygen consumption during hypoxia.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	73-76
6385632-4	1984	The high insulin group, compared with the low insulin group, had overall higher glucose, insulin and C-peptide levels, significantly higher increment 0-40 min of insulin but not C-peptide, and significantly lower maximal oxygen uptake.	Oxygen	221-227	insulin	Homo sapiens	9-16
6701605-1	1984	Chronic granulomatous disease is characterized by recurrent infections with microorganisms which produce catalase, an enzyme that detoxifies endogenous or exogenous hydrogen peroxide to water and oxygen.	Oxygen	196-202	catalase	Homo sapiens	105-113
6319198-0	1984	Kinetic evidence for the re-definition of electron transfer pathways from cytochrome c to O2 within cytochrome oxidase.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	74-86
6319198-1	1984	The reaction with O2 of equimolar mixtures of cytochrome c and cytochrome c oxidase in high and low ionic strength buffers has been examined by flow-flash spectrophotometry at room temperature.	Oxygen	18-20	cytochrome c, somatic	Homo sapiens	46-58
6319198-1	1984	The reaction with O2 of equimolar mixtures of cytochrome c and cytochrome c oxidase in high and low ionic strength buffers has been examined by flow-flash spectrophotometry at room temperature.	Oxygen	18-20	cytochrome c, somatic	Homo sapiens	63-75
6319198-6	1984	Possibilities for new electron transfer pathways from cytochrome c to O2 are proposed.	Oxygen	70-72	cytochrome c, somatic	Homo sapiens	54-66
6741458-5	1984	Even though the red cell 2,3-diphosphoglycerate content was the same in the two groups, and pH was significantly lower in the diabetic women, hemoglobin-oxygen affinity was slightly increased in the diabetic patients (P50 at actual pH: 26.2 versus 26.7 mmHg, p less than 0.05; P50 at pH 7.40: 27.0 versus 28.0 mmHg, p less than 0.01).	Oxygen	153-159	nuclear factor kappa B subunit 1	Homo sapiens	218-221
6398619-4	1984	Because of its anatomical location associated with a low O2 supply imposed by the medullary vascular system and its high rate of electrolyte transport, the mTAL appears to be exquisitely sensitive to O2 deprivation.	Oxygen	57-59	talipes	Mus musculus	156-160
6534112-4	1984	An increase of blood O2 capacity enlarges beta, particularly at deep hypoxia, and also increases the P50 at which maximal beta is reached.	Oxygen	21-23	nuclear factor kappa B subunit 1	Homo sapiens	101-104
6534112-5	1984	Changes of (a-v)O2 have ambivalent effects, depending on both P50 and PaO2.	Oxygen	16-18	nuclear factor kappa B subunit 1	Homo sapiens	62-65
6398619-4	1984	Because of its anatomical location associated with a low O2 supply imposed by the medullary vascular system and its high rate of electrolyte transport, the mTAL appears to be exquisitely sensitive to O2 deprivation.	Oxygen	200-202	talipes	Mus musculus	156-160
6690477-1	1984	A specific anatomical lesion sharply localized to the cells of the medullary thick ascending limbs (mTAL) and characterized by mitochondrial swelling progressing to nuclear pyknosis and cell death is elicited reproducibly in isolated rat kidneys perfused for 15 or 90 min with cell-free albumin-Ringer"s medium gassed with 5% CO2, 95% O2 (O2 content, 1.5 vol/100 ml).	Oxygen	327-329	talipes	Mus musculus	100-104
6543529-1	1984	A model is proposed for the role of the kidney in the control of erythropoietin production in which the initial trigger is an oxygen deficit created by anemia, hypobaria or ischemia.	Oxygen	126-132	erythropoietin	Homo sapiens	65-79
6537800-13	1984	DNA damage was inhibited by superoxide dismutase and catalase, suggesting the involvement of free radicals and active oxygen species.	Oxygen	118-124	catalase	Homo sapiens	53-61
6567480-4	1984	Pressure elevation by angiotensin II also selectively increased tumor oxygen tension and influx of lymph flow from the primary transplanted lesion to the lymph node metastatic lesion.	Oxygen	70-76	angiotensinogen	Homo sapiens	22-36
6690485-0	1984	Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.	Oxygen	19-25	catalase	Rattus norvegicus	82-90
6690485-1	1984	Survival of rats exposed to 100% oxygen was increased from 69.5 +/- 1.5 to 118.1 +/- 9.9 h (mean +/- SEM, P less than 0.05) when liposomes containing catalase and superoxide dismutase were injected intravenously before and during exposure.	Oxygen	33-39	catalase	Rattus norvegicus	150-158
6690485-3	1984	Rats injected with catalase- and superoxide dismutase-containing liposomes, which had increased survival in 100% oxygen, had increased lung wet weight upon autopsy compared with saline-injected controls (2.9 +/- 0.2 g/lung vs. 4.8 +/- 0.4 g/lung, mean +/- SE, P less than 0.05).	Oxygen	113-119	catalase	Rattus norvegicus	19-27
6690477-1	1984	A specific anatomical lesion sharply localized to the cells of the medullary thick ascending limbs (mTAL) and characterized by mitochondrial swelling progressing to nuclear pyknosis and cell death is elicited reproducibly in isolated rat kidneys perfused for 15 or 90 min with cell-free albumin-Ringer"s medium gassed with 5% CO2, 95% O2 (O2 content, 1.5 vol/100 ml).	Oxygen	335-337	talipes	Mus musculus	100-104
6690477-5	1984	Similarly, supplementation of the perfusion medium with a purified hemoglobin (O2 content 5.8 vol/100 ml) prevents mTAL injury.	Oxygen	79-81	talipes	Mus musculus	115-119
6690477-7	1984	These findings suggest that the mTAL is exquisitely susceptible to anoxic damage because of low O2 supply imposed by the medullary vascular system and the high rate of metabolism mandated by active reabsorption of sodium chloride.	Oxygen	96-98	talipes	Mus musculus	32-36
6546402-7	1984	Since cytochrome P-450 and b5 are the major hemoproteins of microsomes and the known source of oxygen-free radical generation, the results obtained in this study appear to indicate that the depression of the hemoprotein of microsomes by the administration of interferon inducers may be largely responsible for the protective effects of these agents against hyperoxia.	Oxygen	95-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	6-29
6690675-5	1984	In the presence of superoxide dismutase and catalase, the 51Cr release was reduced to the control level, indicating the specificity of the effect of oxygen intermediate endothelial cell damage.	Oxygen	149-155	catalase	Homo sapiens	44-52
6533753-1	1984	Hyperbaric oxygen (HPO) was administered to rats (100% O2 at 2.8 atm for 90 min) immediately or 1 hr after severe carbon tetrachloride (CCl4) intoxication in order to study the mechanisms of protection against hepatocellular injury by hyperoxia.	Oxygen	11-17	C-C motif chemokine ligand 4	Rattus norvegicus	136-140
6436930-7	1984	The findings in this experimental study suggest that 60% oxygen ventilation is indicated in the clinical use of vasopressin infusion.	Oxygen	57-63	arginine vasopressin	Homo sapiens	112-123
6666523-9	1983	A concomitant increase in oxygen uptake in preportal tissues occurred (19.9 ml min-1 vs 24.5 ml X min-1).	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	79-84
6719939-6	1984	It is concluded that the hydrogen peroxide-dependent N-demethylation reaction occurs by a reaction mechanism distinct from that occurring during the mixed-function oxidase activity of cytochrome P-450 obtained in the presence of NADPH and oxygen.	Oxygen	239-245	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	184-200
6654893-3	1983	The derivatization increased the oxygen affinity of the molecule (the P50 was lowered from 8.0 to 5.0).	Oxygen	33-39	nuclear factor kappa B subunit 1	Homo sapiens	70-73
6630313-0	1983	Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1.	Oxygen	45-51	POU class 3 homeobox 3	Homo sapiens	139-147
6326394-0	1984	The influence of oxygen donor ligation on the spectroscopic properties of ferric cytochrome P-450: ester, ether and ketone co-ordination to the haem iron.	Oxygen	17-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-97
6326394-8	1984	Anomalous spectral and substrate binding properties have been reported in the study of cytochrome P-450 under conditions employing solvents and non-phosphate buffers containing oxygen functionalities, and have been attributed to "solvent effects".	Oxygen	177-183	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-103
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Oxygen	92-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-134
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Oxygen	92-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	243-259
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Oxygen	171-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-134
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Oxygen	171-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	243-259
6326394-10	1984	This leads us to suggest oxygen-donor ligation to cytochrome P-450 as the origin of spectral and substrate binding anomalies previously attributed to solvent effects.	Oxygen	25-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-66
6372267-1	1984	This review presents current ideas, models and experimental data relating to the precise chemistry that links the transition metal active centre of cytochrome P-450 systems, the unactivated alkane substrate and the triplet atmospheric dioxygen molecule.	Oxygen	235-243	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-164
6315214-3	1983	These have been tentatively identified as bay-region anti-dihydrodiol epoxide: deoxyguanosine- and :deoxyadenosine adducts and a bay-region syn-dihydrodiol epoxide:deoxyadenosine-adduct (where the terms syn and anti define dihydrodiol-epoxides wherein the benzylic hydroxyl group and epoxide oxygen are cis or trans to one another, respectively).	Oxygen	292-298	joined toes	Mus musculus	140-143
6666195-9	1983	The enzyme superoxide dismutase (SOD) converts peroxide radicals (O-2) into hydrogen peroxide (H2O2) which can be inactivated by catalase or peroxidase.	Oxygen	66-69	superoxide dismutase 1	Homo sapiens	33-36
6666195-9	1983	The enzyme superoxide dismutase (SOD) converts peroxide radicals (O-2) into hydrogen peroxide (H2O2) which can be inactivated by catalase or peroxidase.	Oxygen	66-69	catalase	Homo sapiens	129-137
6367914-4	1983	Inactivation of the catalase present endogenously in the mammalian cells by the addition of the catalase inhibitor 3-amino-1,2,4-triazole largely eliminated the enhancing effect of mammalian cells on the survival of T. pallidum under 3% oxygen.	Oxygen	237-243	catalase	Homo sapiens	20-28
6367914-4	1983	Inactivation of the catalase present endogenously in the mammalian cells by the addition of the catalase inhibitor 3-amino-1,2,4-triazole largely eliminated the enhancing effect of mammalian cells on the survival of T. pallidum under 3% oxygen.	Oxygen	237-243	catalase	Homo sapiens	96-104
6666523-9	1983	A concomitant increase in oxygen uptake in preportal tissues occurred (19.9 ml min-1 vs 24.5 ml X min-1).	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
6619872-4	1983	Slices of rat liver incubated in the presence of glucose and beta-methyleneaspartate showed a similar one-to-one relationship between inhibition of oxygen comsumption and inhibition of aspartate aminotransferase activity, whereas with rat kidney cortex slices, the inhibition of aspartate aminotransferase activity was greater than the inhibition of oxygen consumption.	Oxygen	148-154	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	279-305
6671639-3	1983	This system ( [P50-H] ) consists of a fully automatic blood gas analyser and Co-oxymeter and the oxygen equilibrium curve and P50 are mathematically determined with microcomputer.	Oxygen	97-103	nuclear factor kappa B subunit 1	Homo sapiens	15-18
6643179-5	1983	The O2 tension at 50% O2 saturation of Hb (P50) was higher in the more fit subjects (+1.3 mmHg) and the 2,3-DPG concentration was higher (+2.3 mumol/g Hb) in this group.	Oxygen	4-6	nuclear factor kappa B subunit 1	Homo sapiens	43-46
6643179-5	1983	The O2 tension at 50% O2 saturation of Hb (P50) was higher in the more fit subjects (+1.3 mmHg) and the 2,3-DPG concentration was higher (+2.3 mumol/g Hb) in this group.	Oxygen	22-24	nuclear factor kappa B subunit 1	Homo sapiens	43-46
6619872-2	1983	beta-Methylene-D,L-aspartate (2 mM), aminooxyacetate (0.1 mM), and D,L-vinylglycine (20 mM) all significantly reduced the activity of aspartate aminotransferase and the rate of oxygen consumption of rat cerebral cortex slices respiring on glucose.	Oxygen	177-183	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	134-160
6619872-4	1983	Slices of rat liver incubated in the presence of glucose and beta-methyleneaspartate showed a similar one-to-one relationship between inhibition of oxygen comsumption and inhibition of aspartate aminotransferase activity, whereas with rat kidney cortex slices, the inhibition of aspartate aminotransferase activity was greater than the inhibition of oxygen consumption.	Oxygen	350-356	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	185-211
24258230-2	1983	Kinetic analysis showed that within the range from 1 muM to 20 muM O2, the respiration rate of isolated mitochondria and intact plants was a hyperbolic function of the oxygen concentration.	Oxygen	67-69	latexin	Homo sapiens	53-56
24258230-2	1983	Kinetic analysis showed that within the range from 1 muM to 20 muM O2, the respiration rate of isolated mitochondria and intact plants was a hyperbolic function of the oxygen concentration.	Oxygen	67-69	latexin	Homo sapiens	63-66
24258230-2	1983	Kinetic analysis showed that within the range from 1 muM to 20 muM O2, the respiration rate of isolated mitochondria and intact plants was a hyperbolic function of the oxygen concentration.	Oxygen	168-174	latexin	Homo sapiens	53-56
24258230-2	1983	Kinetic analysis showed that within the range from 1 muM to 20 muM O2, the respiration rate of isolated mitochondria and intact plants was a hyperbolic function of the oxygen concentration.	Oxygen	168-174	latexin	Homo sapiens	63-66
24258230-3	1983	The apparent Michaelis constant (K m ) for the oxygen of respiration of intact plants (1.15+-0.08 muM) is close to that for isolated mitochondria (1.07+-0.06 muM), so that diffusion of oxygen within the tissue was obviously not rate-limiting under the applied experimental conditions.	Oxygen	47-53	latexin	Homo sapiens	98-101
24258230-3	1983	The apparent Michaelis constant (K m ) for the oxygen of respiration of intact plants (1.15+-0.08 muM) is close to that for isolated mitochondria (1.07+-0.06 muM), so that diffusion of oxygen within the tissue was obviously not rate-limiting under the applied experimental conditions.	Oxygen	47-53	latexin	Homo sapiens	158-161
24258230-3	1983	The apparent Michaelis constant (K m ) for the oxygen of respiration of intact plants (1.15+-0.08 muM) is close to that for isolated mitochondria (1.07+-0.06 muM), so that diffusion of oxygen within the tissue was obviously not rate-limiting under the applied experimental conditions.	Oxygen	185-191	latexin	Homo sapiens	98-101
6137484-7	1983	A model system, consisting of oxygen, a metal ion, and ascorbic acid, mimics the bacterial system in mediating the oxidative modification of glutamine synthetase.	Oxygen	30-36	glutamate-ammonia ligase	Homo sapiens	141-161
6617658-5	1983	Oxygen dissociation curves of sickle cells showed an effect of Lys-Phe only after incubation for 3 h before measurement, the P50 decreasing from 51 mmHg (6.8 MPa) to 41 mmHg (5.5 MPa) for cells depleted of 2,3-bisphosphoglycerate.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	125-128
6624925-6	1983	Cardiac output was directly proportional to the rate of O2 consumption (VO2, ml X min-1): Q = 17.5 VO2(1.04), with birds having a greater cardiac output for a given VO2 than mammals.	Oxygen	56-58	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
6888481-6	1983	However, alveolar macrophages from subjects exposed to oxygen released increased amounts of fibronectin (P less than 0.05) and alveolar-macrophage--derived growth factor for fibroblasts (P less than 0.01)--mediators thought to modulate fibroblast recruitment and proliferation in the alveolar wall.	Oxygen	55-61	fibronectin 1	Homo sapiens	92-103
6631308-6	1983	Guanethidine, phentolamine and propranolol all produced a significant fall in the basal concentrations of vasopressin, while guanethidine, phenoxybenzamine and propranolol blocked the increase seen on breathing 12% oxygen in nitrogen.	Oxygen	215-221	arginine vasopressin	Rattus norvegicus	106-117
6414504-7	1983	At caesarean section the renin concentration of cord vein blood was positively correlated with carbon dioxide tension and increased dramatically at oxygen tensions less than 3kPa.	Oxygen	148-154	renin	Homo sapiens	25-30
6415111-7	1983	These results suggest that IFN-gamma is the key macrophage-activating molecule present within human lymphokines, and indicate that IFN-gamma can enhance both the oxygen-dependent and -independent antiprotozoal mechanisms of human mononuclear phagocytes.	Oxygen	162-168	interferon gamma	Homo sapiens	27-36
6415111-7	1983	These results suggest that IFN-gamma is the key macrophage-activating molecule present within human lymphokines, and indicate that IFN-gamma can enhance both the oxygen-dependent and -independent antiprotozoal mechanisms of human mononuclear phagocytes.	Oxygen	162-168	interferon gamma	Homo sapiens	131-140
6323037-0	1983	Effects of ceruloplasmin and the haptoglobin-hemoglobin complex on the oxygen-dependent reduction in growth of human diploid fibroblasts in serum-free, albumin containing medium.	Oxygen	71-77	haptoglobin	Homo sapiens	33-44
6632011-0	1983	Effect of circulating fibronectin on stimulation of leukocyte oxygen consumption and serum opsonizing function in burned patients.	Oxygen	62-68	fibronectin 1	Homo sapiens	22-33
6632011-1	1983	In a study of 27 thermally burned patients (mean TBSA, 58%; range, 32-96%) serum fibronectin levels were decreased with parallel decreased oxygen consumption of stimulated peripheral blood phagocytes and decreased EGTA-blocked burn serum opsonizing activity which correlated with serum fibronectin changes postburn.	Oxygen	139-145	fibronectin 1	Homo sapiens	81-92
6632011-4	1983	Supplementary experiments on leukocyte oxidative response after zymosan stimulation in normal, fibronectin-depleted, and fibronectin-reconstituted serum demonstrated that the lag period of oxygen burst is a fibronectin-dependent reaction.	Oxygen	189-195	fibronectin 1	Homo sapiens	95-106
6632011-4	1983	Supplementary experiments on leukocyte oxidative response after zymosan stimulation in normal, fibronectin-depleted, and fibronectin-reconstituted serum demonstrated that the lag period of oxygen burst is a fibronectin-dependent reaction.	Oxygen	189-195	fibronectin 1	Homo sapiens	121-132
6632011-4	1983	Supplementary experiments on leukocyte oxidative response after zymosan stimulation in normal, fibronectin-depleted, and fibronectin-reconstituted serum demonstrated that the lag period of oxygen burst is a fibronectin-dependent reaction.	Oxygen	189-195	fibronectin 1	Homo sapiens	121-132
6626210-1	1983	The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH.	Oxygen	183-185	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-97
6323037-8	1983	Moreover, SOD, Cp, catalase and Hp.Hb (but not Hp) partially prevented oxygen-dependent reduction in growth in an aerobic environment when added to sample A HSA-supplemented medium.	Oxygen	71-77	catalase	Homo sapiens	19-27
6192726-2	1983	In the presence of the reducing agent dithiothreitol, somatostatin was found to inhibit gastrin- and histamine-stimulated acid formation in glands as measured by [14C]aminopyrine (AP) accumulation and oxygen consumption, both measurements that appear to be reliable indexes of parietal cell acid formation.	Oxygen	201-207	somatostatin	Oryctolagus cuniculus	54-66
6636200-7	1983	with 500 mg CCl4/kg expired ethane, propane, and n-pentane, the amounts being higher in the presence of 20% than in the presence of 100% oxygen.	Oxygen	137-143	C-C motif chemokine ligand 4	Rattus norvegicus	12-16
6636200-8	1983	The treatment of rats with FeCl2 30 min after giving CCl4 resulted in a 2-5-fold increase in ethane, propane and n-pentane expiration, the total amounts depending on the oxygen concentration in the respired air (higher under 20% and lower under 100% oxygen).	Oxygen	170-176	C-C motif chemokine ligand 4	Rattus norvegicus	53-57
6355826-9	1983	By DNA-RNA hybridization, catalase T transcripts were shown to be present in oxygen-adapting cells but absent from heme-deficient cells.	Oxygen	77-83	catalase T	Saccharomyces cerevisiae S288C	26-36
16593358-0	1983	Chloroperoxidase generation of singlet Delta molecular oxygen observed directly by spectroscopy in the 1- to 1.6-mum region.	Oxygen	55-61	latexin	Homo sapiens	113-116
6307374-3	1983	In addition, the enzyme was able to generate O2- and its activity was significantly augmented with the homologous liver microsomal cytochrome b5.	Oxygen	45-47	cytochrome b5	Cavia porcellus	131-144
6308055-2	1983	Stimulation of neutrophil oxygen (O2) metabolism with phorbol myristate acetate or opsonized zymosan resulted in production of hydrogen peroxide (H2O2), myeloperoxidase-catalyzed oxidation of chloride (C1-) to hypochlorous acid (HOC1), and the reaction of HOC1 with the added compounds to yield nitrogen-chlorine (N-C1) derivatives.	Oxygen	26-32	myeloperoxidase	Homo sapiens	153-168
6873062-3	1983	Upon oxidation of the [cytochrome P450-Fe(II)(CH3N = NH)] complex with limited amounts of dioxygen, a new complex characterized by a Soret peak at 486 nm is formed.	Oxygen	90-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	23-38
6873062-4	1983	The latter complex was also formed upon slow reaction of methyldiazene with microsomal cytochrome P450-Fe(III) or in situ oxidation of methylhydrazine by limited amounts of O2 or ferricyanide.	Oxygen	173-175	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-102
6308055-2	1983	Stimulation of neutrophil oxygen (O2) metabolism with phorbol myristate acetate or opsonized zymosan resulted in production of hydrogen peroxide (H2O2), myeloperoxidase-catalyzed oxidation of chloride (C1-) to hypochlorous acid (HOC1), and the reaction of HOC1 with the added compounds to yield nitrogen-chlorine (N-C1) derivatives.	Oxygen	34-36	myeloperoxidase	Homo sapiens	153-168
6630164-3	1983	In the livers from fasted, PB-treated rats, 2,4-DNP (50 microM) significantly decreased the amount of reduced (oxygenated) cytochrome P-450 and the drug-induced oxygen uptake by about 50%.	Oxygen	111-117	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	123-139
6876743-2	1983	This study evaluated whether selenium deficiency would prevent an increase in glutathione peroxidase (GSHPX), a selenium-containing enzyme, during oxygen exposure, and, thus, inhibit adaptation.	Oxygen	147-153	glutathione peroxidase 1	Rattus norvegicus	102-107
6876743-7	1983	After oxygen exposure, lung GSHPX activity was elevated in all dietary groups.	Oxygen	6-12	glutathione peroxidase 1	Rattus norvegicus	28-33
6888290-3	1983	We compared the theoretical predictions with the results of our previous stopped-flow experiments with suspensions of red cells to which bovine serum albumin (BSA) had been added to decrease O2 solubility and diffusivity (Huxley and Kutchai, 1981).	Oxygen	191-193	albumin	Homo sapiens	144-157
6615235-7	1983	The system has been applied for a study on the oxygen-dependence of CCl4-metabolism in the rat.	Oxygen	47-53	C-C motif chemokine ligand 4	Rattus norvegicus	68-72
6872096-5	1983	BHA addition effectively discharged the activated oxygen complex of cytochrome P-450 (liver microsomes) as well as Comp.	Oxygen	50-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-84
6613609-2	1983	Inhibition of the reaction by CO and by SKF 525A and the absolute dependence on NADPH and oxygen indicate that cytochrome P-450 catalyzes the reaction.	Oxygen	90-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-127
6349758-2	1983	In the absence of insulin, only oxygen consumption was significantly elevated by taurine; however, in the presence of 2.5 U/L insulin the amino acid caused the stimulation of glycolysis and glycogenesis, as well as oxygen utilization.	Oxygen	215-221	insulin	Homo sapiens	126-133
6882464-4	1983	During benzyl halide reduction, cytochrome P-450 complexes, which are very unstable to O2 and characterized by a Soret peak at 478 nm, are formed in steady-state concentrations.	Oxygen	87-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
6305210-8	1983	Neurotensin given intra-arterially directly to the pancreas or to isolated intestinal segment increased dose dependently the blood flow and oxygen consumption without affecting general circulation.	Oxygen	140-146	neurotensin	Canis lupus familiaris	0-11
6883619-5	1983	Total body maximal oxygen uptake averaged (+/- SD) 5.36 +/- 0.25 l X min-1.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	69-74
6612900-7	1983	From 1 ATA to 4 ATA r decreased from 0.78 to 0.53 while the standard error of VO2 estimated from HR (Syx) increased from 0.229 to 0.582 liters O2.	Oxygen	79-81	pleckstrin homology and RhoGEF domain containing G5	Homo sapiens	101-104
6853522-7	1983	These results, along with studies of other workers, suggest that cytochrome P-450 forms an active complex with O2 which is stable for at least many milliseconds.	Oxygen	111-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	65-81
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Oxygen	181-183	lactoperoxidase	Homo sapiens	29-44
6189859-1	1983	Myeloperoxidase (MPO), a heme enzyme present in the azurophilic granules of human polymorphonuclear neutrophils (PMN), is important in the oxygen-dependent microbicidal activity of PMN.	Oxygen	139-145	myeloperoxidase	Homo sapiens	0-15
6189859-1	1983	Myeloperoxidase (MPO), a heme enzyme present in the azurophilic granules of human polymorphonuclear neutrophils (PMN), is important in the oxygen-dependent microbicidal activity of PMN.	Oxygen	139-145	myeloperoxidase	Homo sapiens	17-20
6408048-3	1983	Partial pressure of O2 in arterial blood (PaO2) and arterial pH, (pHa) also reflected hyperventilation.	Oxygen	20-22	lamin B receptor	Homo sapiens	66-69
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Oxygen	181-183	lactoperoxidase	Homo sapiens	46-49
6840425-3	1983	The content of 2,3-diphosphoglycerate correlated significantly with haemoglobin-oxygen affinity expressed as P50 at pH 7.4 (r = 0.34, p less than 0.05).	Oxygen	80-86	nuclear factor kappa B subunit 1	Homo sapiens	109-112
6825792-0	1983	A nonenzymic oxygen uptake and its implications in the assay of 4-hydroxyphenylpyruvate dioxygenase by an oxygen electrode.	Oxygen	13-19	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	64-99
6833254-0	1983	Kinetics of O2 and CO Binding to adrenal cytochrome P-450scc.	Oxygen	12-14	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	41-60
6833254-2	1983	The kinetics of O2 and CO binding to purified adrenal cytochrome P-450scc has been measured at 25 degrees C by stopped flow spectrophotometry.	Oxygen	16-18	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	54-73
6833254-4	1983	22R-Hydroxycholesterol and 20 alpha,22R-dihydroxycholesterol, intermediates in the cytochrome P-450scc-catalyzed conversion of cholesterol to pregnenolone, markedly influenced rates and equilibria of O2 and CO binding.	Oxygen	200-202	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	83-102
6868075-1	1983	Growth promoting activity of bovine serum albumin for human diploid fibroblasts was affected by oxygen environment.	Oxygen	96-102	albumin	Homo sapiens	36-49
6339228-15	1983	It also has GSH peroxidase activity which suggests that it might participate in the detoxication of by-products of oxygen utilization including those produced by the action of cytochrome P-450.	Oxygen	115-121	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	176-192
6835721-2	1983	As the deleterious effect of oxygen derivatives in the cell is one of the numerous pathways associated with cell aging, the activity of the enzymatic defense system, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione reductase (GR), was examined in the erythrocytes of 12 CF children and was compared to age-matched normal controls.	Oxygen	29-35	superoxide dismutase 1	Homo sapiens	166-186
6673053-4	1983	Mean oxygen consumption in the prehepatic splanchnic area was 0.27 +/- 0.04 ml X min-1 X kg-1.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
27463166-2	1983	Before the program they had 12.2% body fat and maximal oxygen consumption of 64.7 ml  kg(-1)  min(-1) during bicycle ergometry.	Oxygen	55-61	CD59 molecule (CD59 blood group)	Homo sapiens	94-100
6185486-10	1983	Although iron bleomycin does not have a polyaromatic structure like heme, many features of its electronic structure at the iron are very similar to those produced by the sulfur-coordinated heme iron of ferric cytochrome P-450, a protein that catalyzes a similar oxygen-dependent reaction.	Oxygen	262-268	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	209-225
6435638-0	1983	[Mechanism of oxygen exchange in the amide group of substrates during their hydrolysis catalyzed by leucine aminopeptidase and pepsin].	Oxygen	14-20	carboxypeptidase Q	Homo sapiens	108-122
6435638-1	1983	Oxygen exchange in the amide group of leucine amide catalyzed by leucine aminopeptidase, and in leucyltyrosine amide catalyzed by porcine pepsin, was found to proceed mainly by the transfer of the leucyl residue onto the ammonia or tyrosine amide which are formed during the hydrolysis.	Oxygen	0-6	carboxypeptidase Q	Homo sapiens	73-87
6403493-5	1983	Other attempts to predict blood O2 affinity have considered only P50 (the Po2 at one-half saturation with O2) or have provided too little data for continuous simulations.	Oxygen	32-34	nuclear factor kappa B subunit 1	Homo sapiens	65-68
6404258-3	1983	Evidence is presented that the EDTA inhibition of O2 evolution is linked partly to the removal of one Mn atom per PS2 reaction centre and partly to the removal of extrinsic membrane proteins having apparent molecular weights between 58 and 70 kdaltons.	Oxygen	50-52	taste 2 receptor member 64 pseudogene	Homo sapiens	114-117
6297957-1	1983	Oxygen uptake by neutrophils has been stimulated by particulate serum-treated-zymosan (STZ) and soluble N-formylmethionyl-leucyl-phenylalanine (FMLP) in the presence and absence of the superoxide radical scavenger, cytochrome C.	Oxygen	0-6	formyl peptide receptor 1	Homo sapiens	144-148
6838544-0	1983	Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen.	Oxygen	74-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
6838544-2	1983	Rat liver cytochrome P-450 mediates a novel reaction between equimolar quantities of dissolved oxygen and organic hydroperoxides.	Oxygen	95-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	10-26
6838544-5	1983	Monitoring the rate of O2 consumption in this novel reaction may be a simple and rapid means for studying the kinetics of cytochrome P-450.	Oxygen	23-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
6297957-1	1983	Oxygen uptake by neutrophils has been stimulated by particulate serum-treated-zymosan (STZ) and soluble N-formylmethionyl-leucyl-phenylalanine (FMLP) in the presence and absence of the superoxide radical scavenger, cytochrome C.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	215-227
6340440-3	1983	The lung injury is closely linked to availability of complement and neutrophils and can be prevented by systemic treatment of animals with a combination of superoxide dismutase and catalase, specific inhibitors of toxic oxygen metabolites.	Oxygen	220-226	catalase	Rattus norvegicus	181-189
6356808-5	1983	Using this approach, we have found an excellent correlation between the rate of cellular oxygen utilization by a single cell suspension and the net radio-sensitivity of multicell spheroids when treated with modulating agents, varying from direct control of metabolic activity by changing the ambient temperature, to less direct effects on cellular oxygen consumption induced by exposure of cells to nitroheterocyclic radiosensitizers, chemotherapeutic agents, anesthetics, antibiotics, and even cell growth factors including insulin.	Oxygen	89-95	insulin	Homo sapiens	525-532
6305528-3	1983	Catalase and superoxide dismutase were used to identify the formation of these active oxygens.	Oxygen	86-93	catalase	Homo sapiens	0-8
6675687-3	1983	The actual oxygen affinity significantly decreased after exercise with the values of log p50 [act] equal 1.42 +/- 0.1 at rest and 1.51 +/- 0.12 after the effort; the difference was assessed by the nonparametric test of pairs [p less than 0.05].	Oxygen	11-17	nuclear factor kappa B subunit 1	Homo sapiens	89-92
6376215-4	1983	High oxygen concentration was beneficial for high release of IL-2 and MCF, whereas MIF and TRF were better produced at low oxygen concentrations.	Oxygen	123-129	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	83-86
6360680-0	1983	Greater serum GH response to arm than to leg exercise performed at equivalent oxygen uptake.	Oxygen	78-84	growth hormone 1	Homo sapiens	14-16
6685029-4	1983	Maximal oxygen uptake VO2max) in the fast group (X +/- SD; 45.3 +/- 5.5 ml x kg-1 x min-1) was significantly greater (p less than 0.05) than the slow group (39.8 +/- 5.9 ml x kg-1 x min-1).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	182-187
6842358-3	1983	Twenty-two sets of analyses were performed to measure oxygen affinity (P50) 2,3-diphosphoglycerate concentration and full blood gas analysis on umbilical arterial and venous samples.	Oxygen	54-60	nuclear factor kappa B subunit 1	Homo sapiens	71-74
6297637-1	1983	Myeloperoxidase (MPO), a heme enzyme present in the primary granules of polymorphonuclear leukocytes (PMNs), has been demonstrated to participate in the oxygen-dependent microbicidal activity of these cells.	Oxygen	153-159	myeloperoxidase	Homo sapiens	0-15
6297637-1	1983	Myeloperoxidase (MPO), a heme enzyme present in the primary granules of polymorphonuclear leukocytes (PMNs), has been demonstrated to participate in the oxygen-dependent microbicidal activity of these cells.	Oxygen	153-159	myeloperoxidase	Homo sapiens	17-20
6297637-4	1983	The role of MPO in PMN oxygen metabolism was examined by studying parameters of the respiratory burst of PMNs from a number of unrelated MPO-deficient subjects; in addition, the ability of heme enzyme inhibitors to duplicate the MPO-deficient state was studied by treating normal and MPO-deficient cells with these compounds.	Oxygen	23-29	myeloperoxidase	Homo sapiens	12-15
6817796-6	1982	The squalene epoxidase activity was reconstituted with the purified enzyme, NADPH-cytochrome P-450 reductase (EC 1.6.2.4), FAD, NADPH and molecular oxygen in the presence of Triton X-100.	Oxygen	148-154	squalene epoxidase	Rattus norvegicus	4-22
6295471-4	1982	Owing to the presence of a trace amount of cytochrome oxidase in the reductase preparation employed, the addition of cytochrome c makes electron flow from substrate to oxygen possible.	Oxygen	168-174	cytochrome c, somatic	Homo sapiens	117-129
6836197-2	1983	Since the rat haemoglobin exhibited a lower oxygen affinity than guinea pig haemoglobin, the oxygen partial pressure at 50% of oxygen haemoglobin saturation (P50) increased from 25.2 +/- 1.1 to 37.2 +/- 0.9 mm Hg (n = 10).	Oxygen	93-99	neuronal pentraxin-2	Cavia porcellus	158-161
6836197-2	1983	Since the rat haemoglobin exhibited a lower oxygen affinity than guinea pig haemoglobin, the oxygen partial pressure at 50% of oxygen haemoglobin saturation (P50) increased from 25.2 +/- 1.1 to 37.2 +/- 0.9 mm Hg (n = 10).	Oxygen	93-99	neuronal pentraxin-2	Cavia porcellus	158-161
6836197-3	1983	This increase in P50 was accompanied by a significant increase in arterial oxygen partial pressure (PaO2) and in arterio-venous difference (AVDO2).	Oxygen	75-81	neuronal pentraxin-2	Cavia porcellus	17-20
6836197-5	1983	The increase in P50 was associated with a venous oxygen partial pressure (P-VO2) which remained constant but an increase in blood lactate concentration was observed.	Oxygen	49-55	neuronal pentraxin-2	Cavia porcellus	16-19
7138788-7	1982	The heightened response of BFU-E to Epo, analogous to the effect seen for CFU-E, implies that BFU-E may be responsive to physiological Epo concentrations at physiological oxygen tensions.	Oxygen	171-177	erythropoietin	Homo sapiens	36-39
6816098-10	1982	min-1 (n = 10) of etomidate in air-oxygen mixture.	Oxygen	35-41	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
6297496-10	1982	The aerobic activation of nitrofurantoin by xanthine oxidase involved the superoxide anion as an intermediate, whereas the nitrofuran was directly reduced by ferredoxin-(cytochrome c)-NADP+ oxidoreductase without a requirement for active oxygen species.	Oxygen	238-244	cytochrome c, somatic	Homo sapiens	170-182
6292259-2	1982	NK-target-cell interaction appears to involve carbohydrate recognition and, following binding, the NK cells are induced to generate O2-, transmethylate membrane phospholipids, and activate phospholipase A2.	Oxygen	132-134	phospholipase A2 group IB	Homo sapiens	189-205
6816650-1	1982	The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes.	Oxygen	52-58	nuclear factor kappa B subunit 1	Homo sapiens	60-63
7161599-11	1982	Similarities between the hemin-mediated peroxide-supported reactions reported here, and the cytochrome P-450-mediated peroxide-supported reactions reinforce our earlier contentions that the alkaline hemin system appears to be a good model for the in vivo activation of oxygen by hemoproteins.	Oxygen	269-275	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108
6293826-5	1982	Catalase T and A mRNAs are accumulated rapidly during adaptation of anaerobic cells to oxygen.	Oxygen	87-93	catalase T	Saccharomyces cerevisiae S288C	0-10
6125342-4	1982	In the next 8 patients, vasopressin, 0.4 U/min infused over 30 min, caused a more persistent pulmonary and systemic hypertension and bradycardia, a slight increase in P(A.a)O2 and Qsp/Qt, a reduction in O2 del (-27%) and a decrease in portal pressures (-32%).	Oxygen	173-175	arginine vasopressin	Homo sapiens	24-35
7137869-1	1982	The affinity of haemoglobin for oxygen may be expressed as the oxygen tension at 50% saturation under standard conditions (P50).	Oxygen	32-38	nuclear factor kappa B subunit 1	Homo sapiens	123-126
7137869-1	1982	The affinity of haemoglobin for oxygen may be expressed as the oxygen tension at 50% saturation under standard conditions (P50).	Oxygen	63-69	nuclear factor kappa B subunit 1	Homo sapiens	123-126
7138903-5	1982	A NADH-dependent production of hydrogen peroxide was observed by measuring the difference of oxygen uptake in the presence and absence of catalase (500 units), which was not inhibited by potassium cyanide (1 mM).	Oxygen	93-99	catalase	Homo sapiens	138-146
6125342-4	1982	In the next 8 patients, vasopressin, 0.4 U/min infused over 30 min, caused a more persistent pulmonary and systemic hypertension and bradycardia, a slight increase in P(A.a)O2 and Qsp/Qt, a reduction in O2 del (-27%) and a decrease in portal pressures (-32%).	Oxygen	203-205	arginine vasopressin	Homo sapiens	24-35
7120526-3	1982	However, the low P50 of stored blood may increase the affinity of hemoglobin for oxygen and reduce oxygen consumption.	Oxygen	81-87	nuclear factor kappa B subunit 1	Homo sapiens	17-20
7120526-3	1982	However, the low P50 of stored blood may increase the affinity of hemoglobin for oxygen and reduce oxygen consumption.	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	17-20
6807602-0	1982	High-pressure ventilation during CPR with 95% O2:5% CO2.	Oxygen	46-48	cytochrome p450 oxidoreductase	Canis lupus familiaris	33-36
6807602-4	1982	Ventilation with 5% CO2-enriched oxygen during CPR maintained acid/base status near prearrest values (pH = 7.22, PCO2 = 30.3 after 1:1; pH = 7.26, PCO2 = 28.0 after 1:5).	Oxygen	33-39	cytochrome p450 oxidoreductase	Canis lupus familiaris	47-50
6750080-4	1982	They were able to ensure oxygen transfer: the dissociation curve was sigmoidal with a p50 = 13 mm Hg.	Oxygen	25-31	nuclear factor kappa B subunit 1	Homo sapiens	86-89
7091207-5	1982	P50 (oxygen affinity, i.e., Po2 at 50% oxygen saturation) at actual pH correlated inversely with Hb Alc of the diabetic women (r = -0.45, p less than 0.05).	Oxygen	5-11	nuclear factor kappa B subunit 1	Homo sapiens	0-3
7091207-5	1982	P50 (oxygen affinity, i.e., Po2 at 50% oxygen saturation) at actual pH correlated inversely with Hb Alc of the diabetic women (r = -0.45, p less than 0.05).	Oxygen	39-45	nuclear factor kappa B subunit 1	Homo sapiens	0-3
6281256-5	1982	In the present study, superoxide dismutase and catalase, scavengers of radical oxygens, were found to protect against islet DNA strand breaks and inhibition of proinsulin synthesis induced by alloxan.	Oxygen	79-86	catalase	Rattus norvegicus	47-55
6282362-6	1982	However, pretreatment with PAF (10(-7) M) enhanced approximately threefold the O2 utilization found when cells were subsequently stimulated with 10(-7) M FMLP.	Oxygen	79-81	formyl peptide receptor 1	Homo sapiens	154-158
6286312-4	1982	The kinetic properties of cytochrome c oxidases from beef liver and heart were measured with intact cytochrome c-depleted membranes, deoxycholate-dissolved membranes, and with the isolated enzymes at various cytochrome c concentrations with an oxygen electrode.	Oxygen	244-250	cytochrome c, somatic	Homo sapiens	26-38
7091622-5	1982	However, the higher the oxygen consumption and therefore the saturation change, and/or the more pronounced the hypoxia, the more the P50 found in vivo coincides with the theoretical optimum.	Oxygen	24-30	nuclear factor kappa B subunit 1	Homo sapiens	133-136
6282363-1	1982	We previously demonstrated that neutrophil (PMN) phagocytosis of opsonized zymosan (OPZ) caused oxygen-dependent inhibition of chemotactic peptide receptor (CPR) binding using the ligand 3H-formyl-methionyl-leucyl-phenylalanine (3H-FMLP).	Oxygen	96-102	formyl peptide receptor 1	Homo sapiens	232-236
6284205-6	1982	These studies of the binding of peroxide clarify the mechanism by which cytochrome c oxidase catalyzes the reduction of oxygen to water without the formation of free-radical intermediates.	Oxygen	120-126	cytochrome c, somatic	Homo sapiens	72-84
7115348-1	1982	The specific activities of Cu,Zn- and Mn-superoxide dismutases, of glutathione peroxidase and of catalase, the enzymes considered to be specifically involved in the defence of the cell against the partially reduced forms of oxygen, were determined as the function of postnatal age in the early (up to 60 days) period of rat brain development.	Oxygen	224-230	catalase	Rattus norvegicus	97-105
7066906-1	1982	Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic oxygen reduction metabolites.	Oxygen	177-183	catalase	Homo sapiens	93-101
6461279-0	1982	Antidiuretic and growth hormone responses during coronary artery surgery with sufentanil-oxygen and alfentanil-oxygen anesthesia in man.	Oxygen	89-95	growth hormone 1	Homo sapiens	17-31
6461279-0	1982	Antidiuretic and growth hormone responses during coronary artery surgery with sufentanil-oxygen and alfentanil-oxygen anesthesia in man.	Oxygen	111-117	growth hormone 1	Homo sapiens	17-31
6126248-0	1982	Bombesin and somatostatin related peptides: effects on oxygen consumption.	Oxygen	55-61	somatostatin	Rattus norvegicus	13-25
6126248-1	1982	Bombesin and the somatostatin analog, desAA-[D-Trp8]-somatostatin (ODT8-SS), act within the central nervous system to alter animals" oxygen consumption (VO2) in a manner consistent with the observed effects of these peptides on temperature regulation.	Oxygen	133-139	somatostatin	Rattus norvegicus	17-29
6126248-1	1982	Bombesin and the somatostatin analog, desAA-[D-Trp8]-somatostatin (ODT8-SS), act within the central nervous system to alter animals" oxygen consumption (VO2) in a manner consistent with the observed effects of these peptides on temperature regulation.	Oxygen	133-139	somatostatin	Rattus norvegicus	53-65
6802831-10	1982	In addition, the diazene-bound heme of cytochrome P-450 apparently was modified irreversibly in the presence of oxygen.	Oxygen	112-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-55
6918393-2	1982	Whereas, a beta blocker functions by reducing oxygen demand, the calcium antagonists increase oxygen supply and also decrease oxygen demand.	Oxygen	46-52	amyloid beta precursor protein	Homo sapiens	9-15
7064994-1	1982	Previous studies from our laboratory suggested a decrease in tissue oxygen delivered during hemodialysis of chronic uremic patients due to an increase in hemoglobin-oxygen affinity, i.e. decrease in P50.	Oxygen	68-74	nuclear factor kappa B subunit 1	Homo sapiens	199-202
7085405-1	1982	A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption.	Oxygen	98-104	nuclear factor kappa B subunit 1	Homo sapiens	106-109
7085405-1	1982	A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption.	Oxygen	133-139	nuclear factor kappa B subunit 1	Homo sapiens	106-109
7085405-1	1982	A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption.	Oxygen	133-139	nuclear factor kappa B subunit 1	Homo sapiens	106-109
6803400-0	1982	CCl4-induced lipid peroxidation in isolated rat hepatocytes with different oxygen concentrations.	Oxygen	75-81	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
6801051-6	1982	Correlation of the structures of the five analogues with their activities indicates that the enzyme requires a syn orientation of the carbon-oxygen bonds about C-2 and C-3 for activity, which is optimized by an anti relationship between the hydroxyl groups at C-1 and C-2 of the cyclopentanetriol monophosphates.	Oxygen	141-147	complement C2	Oryctolagus cuniculus	160-171
6801051-6	1982	Correlation of the structures of the five analogues with their activities indicates that the enzyme requires a syn orientation of the carbon-oxygen bonds about C-2 and C-3 for activity, which is optimized by an anti relationship between the hydroxyl groups at C-1 and C-2 of the cyclopentanetriol monophosphates.	Oxygen	141-147	complement C2	Oryctolagus cuniculus	260-271
7076851-15	1982	NK was also suppressed by the enzymatic generation of O2- from xanthine oxidase and xanthine, but suppression under these conditions was again inhibited by catalase and not by superoxide dismutase, indicating that suppression was due to the secondary formation of H2O2 from O2-.	Oxygen	266-268	catalase	Homo sapiens	156-164
7064994-1	1982	Previous studies from our laboratory suggested a decrease in tissue oxygen delivered during hemodialysis of chronic uremic patients due to an increase in hemoglobin-oxygen affinity, i.e. decrease in P50.	Oxygen	165-171	nuclear factor kappa B subunit 1	Homo sapiens	199-202
6802762-4	1982	We found that the penA2 and mtr-2 mutations each markedly increased sensitivity of strain FA19 to oxygen-independent killing by human polymorphonuclear leukocyte mixed or isolated azurophilic granule extracts.	Oxygen	98-104	cap methyltransferase 2	Homo sapiens	28-33
6279843-2	1982	It was concluded that the interaction involves a hydrogen bond from a donor site on ACE to the oxygen of the amide carbonyl.	Oxygen	95-101	angiotensin I converting enzyme	Homo sapiens	84-87
7038471-2	1982	In haploids, reduced oxygen enhancement ratios were found in rad52, rad6 and rad18.	Oxygen	21-27	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	77-82
7038471-4	1982	In diploids the oxygen effect was decreased in rad2, rad52 and rad18.	Oxygen	16-22	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	63-68
6803786-0	1982	Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water.	Oxygen	66-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
6279107-2	1982	Cytochrome oxidase is a mitochondrial trans-membrane protein which catalyzes the vectorial transfer of electrons from cytochrome c to molecular oxygen.	Oxygen	144-150	cytochrome c, somatic	Homo sapiens	118-130
6283828-4	1982	Reduction of exogenous cytochrome C accounted for only about 15% of the consumed oxygen.	Oxygen	81-87	cytochrome c, somatic	Homo sapiens	23-35
7188389-0	1982	Selective increase in tumor oxygen tension with angiotensin II.	Oxygen	28-34	angiotensinogen	Rattus norvegicus	48-62
7200881-2	1982	Ventilation, gas exchange and heart rate were closely matched in all four tests in each child, with a mean oxygen consumption of 32.3 +/- 1.7 ml x min-1 x kg-1.	Oxygen	107-113	CD59 molecule (CD59 blood group)	Homo sapiens	147-152
7068434-0	1982	Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact.	Oxygen	87-93	carboxylesterase 2	Homo sapiens	30-33
7184712-9	1982	Superoxide dismutase, catalase and glutathione peroxidase, the defensive enzymes against reactive species of oxygen, were decreased 54%, 57% and 62% respectively in cataract, exposing the lens to oxidants such as 02(-), H202, 0H.	Oxygen	109-115	catalase	Mus musculus	22-30
6185446-8	1982	The change in coronary vascular resistance and myocardial oxygen consumption were likewise related to the resting plasma renin level.	Oxygen	58-64	renin	Homo sapiens	121-126
7188389-1	1982	A rise in mean arterial blood pressure to approximately 150 mm Hg by infusion of angiotensin II was accompanied by an approximate 6.4-fold selective increase in oxygen tension in tumor tissue without increasing oxygen tension in uninvolved tissues of the tumor-bearing host.	Oxygen	161-167	angiotensinogen	Rattus norvegicus	81-95
7298642-1	1981	This paper examines the reaction pathway in which Fe2+ is bound by apotransferrin and subsequently oxidized by O2 to yield Fe3+-transferrin-CO3(2-).	Oxygen	111-113	transferrin	Homo sapiens	70-81
7062313-7	1982	Results suggested that the phagocytic CL response in our assay system was dependent on O2 activation followed by the activated O2 species reacting with myeloperoxidase and chloride.	Oxygen	127-129	myeloperoxidase	Homo sapiens	152-167
7167385-4	1982	In parallel, oxygen affinity is lower, as the P50 value is displaced to the right by 2 mmHg above the normal mean, thus assuring adequate tissue oxygenation.	Oxygen	13-19	nuclear factor kappa B subunit 1	Homo sapiens	46-49
7298642-7	1981	A second order rate constant of approximately 4 X 10(3) M-1 s-1 was estimated for the oxidation of Fe2+-transferrin-CO3(2-) by O2.	Oxygen	127-129	transferrin	Homo sapiens	104-115
7298642-9	1981	The reaction velocity increases with increasing pH between pH 6.0 and 7.5 Fe3+-transferrin-anion complexes are formed by the binding and oxidation of Fe2+ iun the presence of O2 and synergistic anions.	Oxygen	175-177	transferrin	Homo sapiens	79-90
6267131-0	1981	Regulation by PGE2 of the production of oxygen intermediates by LPS-activated macrophages.	Oxygen	40-46	toll-like receptor 4	Mus musculus	64-67
7318140-2	1981	Maximal oxygen uptake (2.47 +/- 0.36 l-min-1) was measured on a treadmill test.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
7287710-7	1981	These findings lead to a view that the proton-catalyzed nucleophilic displacement of O2- from MbO2 by an entering water molecule, or SN2 mechanism with proton assistance, is the basis for most of the autoxidation reaction under normal conditions.	Oxygen	85-87	solute carrier family 38 member 5	Homo sapiens	133-136
7295780-11	1981	Thus, the CO, O2 and NO-bound forms of cytochrome P-450cam, which have two pi-type axial ligands, showed the smallest alpha-MCD bands ([theta]M = 5.2-7.5) among complexes, while ferrous cytochrome b5 and cytochrome c, which have two sigma-electron-donating axial ligands, showed the largest magnitude ([theta]M = 120-176).	Oxygen	14-16	cytochrome c, somatic	Homo sapiens	204-216
6793678-2	1981	The oxygen affinity of SS blood (measured as P50) is significantly decreased when this blood is exposed for 30 min to nitrogen before the determination of the oxygen equilibrium curve.	Oxygen	4-10	nuclear factor kappa B subunit 1	Homo sapiens	45-48
6793678-2	1981	The oxygen affinity of SS blood (measured as P50) is significantly decreased when this blood is exposed for 30 min to nitrogen before the determination of the oxygen equilibrium curve.	Oxygen	159-165	nuclear factor kappa B subunit 1	Homo sapiens	45-48
7301458-2	1981	At the lower oxygen tension, SOD rose two-fold and GPx decreased significantly by 18 hr and throughout the exposure periods compared to a delayed increase in SOD activity which was not sustained beyond 66 hr of exposure and a sustained rise in GPx to an FIO2 of 85%.	Oxygen	13-19	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	29-32
7290468-3	1981	These two conditions could be coexisting in an unstable, non-enzymatic equilibrium, which could modify by itself the usual sigmoid shape (and the P50 values) of the whole blood oxygen affinity.	Oxygen	177-183	nuclear factor kappa B subunit 1	Homo sapiens	146-149
7301458-2	1981	At the lower oxygen tension, SOD rose two-fold and GPx decreased significantly by 18 hr and throughout the exposure periods compared to a delayed increase in SOD activity which was not sustained beyond 66 hr of exposure and a sustained rise in GPx to an FIO2 of 85%.	Oxygen	13-19	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	158-161
7309708-3	1981	The various spectral data indicated that the Co(II) center has tetrahedral geometry (high-spin state) and is linked by two nitrogens and two oxygens.	Oxygen	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
7235917-6	1981	The energy cost (oxygen consumption) VO2.wt-1 (ml.min-1.kg-1) of ambulating with underarm crutches compared to normal walking was approximately twice as great.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	50-55
6270623-5	1981	Fetal arterial pH and oxygen tension was inversely correlated with plasma vasopressin (P less than 0.01).	Oxygen	22-28	arginine vasopressin	Homo sapiens	74-85
7263679-5	1981	This partition number is corrected for the competing O2-dependent autoinactivation of cytochrome P-450 which we have previously shown to occur with the purified isozyme (Loosemore, M., Light, D. R., and W#alsh, C. (1980) J. Biol.	Oxygen	53-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	86-102
6265441-1	1981	Addition of exogenous NADH to rotenone- and antimycin A-treated mitochondria, in 125 mM KCl, results in rates of oxygen uptake of 0.5-1 and 10-12 nanoatoms of oxygen X mg protein-1 X min-1 in the absence and presence of cytochrome c, respectively.	Oxygen	113-119	cytochrome c, somatic	Homo sapiens	220-232
6265441-8	1981	It is concluded that aerobic oxidation of exogenous NADH involves the following pathway: NADH leads to NADH-cytochrome b5 reductase leads to cytochrome b5 leads to intermembrane cytochrome c leads to cytochrome oxidase leads to oxygen.	Oxygen	228-234	cytochrome c, somatic	Homo sapiens	178-190
6269598-0	1981	Electrocatalytic four-electron reduction of oxygen at the cytochrome c3-adsorbed electrode.	Oxygen	44-50	cytochrome c, somatic	Homo sapiens	58-70
6269598-1	1981	The electrocatalytic activity of cytochrome c3 for the reduction of molecular oxygen was characterized from the studies of the adsorption of cytochrome c3 and the co-adsorption of cytochrome cs with cytochrome c on the mercury electrode by the a.c. polarographic technique.	Oxygen	78-84	cytochrome c, somatic	Homo sapiens	33-45
6269598-1	1981	The electrocatalytic activity of cytochrome c3 for the reduction of molecular oxygen was characterized from the studies of the adsorption of cytochrome c3 and the co-adsorption of cytochrome cs with cytochrome c on the mercury electrode by the a.c. polarographic technique.	Oxygen	78-84	cytochrome c, somatic	Homo sapiens	141-153
6269598-9	1981	Cytochrome c3 catalyzes the electrochemical reduction of molecular oxygen from the two-electron pathways via hydrogen peroxide to the four-electron pathway at the mercury electrode in neutral phosphate buffer solution.	Oxygen	67-73	cytochrome c, somatic	Homo sapiens	0-12
6973550-6	1981	The use of buffer saturated with oxygen accelerated the aerobic rates of increase of permeability and inactivation of GAPDH by 60- and 2.7-fold.	Oxygen	33-39	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	118-123
6973550-7	1981	These results indicate that inactivation of GAPDH is somewhat sensitive to oxygen, particularly at high concentration of oxygen.	Oxygen	75-81	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	44-49
6973550-7	1981	These results indicate that inactivation of GAPDH is somewhat sensitive to oxygen, particularly at high concentration of oxygen.	Oxygen	121-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	44-49
6972926-4	1981	Except in Eagle"s medium, hydrogen peroxide is formed in the anoxic solutions, and molecular oxygen can be detected after irradiation when catalase is present in the solution.	Oxygen	93-99	catalase	Homo sapiens	139-147
7199410-9	1981	Maximal oxygen uptake was only 35 (males) and 29 (females) ml/kg min-1; this contrasted with the physical activity pattern of these patients, yet was in line with their small muscle mass with its low oxidative potential.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	65-70
7320883-3	1981	Bovine serum albumin (BSA) was added to the extracellular fluid to enhance the effect of the diffusion boundary layer by diminishing both the solubility and the diffusivity of O(2).	Oxygen	176-180	albumin	Homo sapiens	7-20
7262071-4	1981	This establishes a role for cytochrome b5 in donating electrons for the reduction of oxy-cytochrome P-450 to the active oxygen complex of cytochrome P-450 but also points to large variations in the importance of this role depending on the experimental conditions, the species of P-450 involved and the substrates employed.	Oxygen	120-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105
7262071-4	1981	This establishes a role for cytochrome b5 in donating electrons for the reduction of oxy-cytochrome P-450 to the active oxygen complex of cytochrome P-450 but also points to large variations in the importance of this role depending on the experimental conditions, the species of P-450 involved and the substrates employed.	Oxygen	120-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	138-154
7268194-6	1981	Oxygen consumption was accelerated when xanthomegnin was added to a reaction medium containing NADH, NADH segment and cytochrome c oxidase.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	118-130
7255137-4	1981	Since dwarfs had normal platelet malonyldialdehyde production, it is likely that the mitochondrial component of thrombin-induced high oxygen consumption was deficient.	Oxygen	134-140	coagulation factor II, thrombin	Homo sapiens	112-120
7268194-7	1981	Subsequent addition of cytochrome c resulted in a further marked acceleration of oxygen consumption.	Oxygen	81-87	cytochrome c, somatic	Homo sapiens	23-35
6973361-5	1981	Photooxidation systems of lipids and rhodopsin also react differently to oxygen content in the incubation medium.	Oxygen	73-79	rhodopsin	Homo sapiens	37-46
6788083-6	1981	The large magnitude of these KIEs requires that carbon-oxygen bond scission be far advanced in the transition states for these reactions; therefore in the transition states for the first irreversible steps in these reaction sequences, scission of the glycosidic bond must be essentially complete for the reactions catalyzed by lysozyme and beta-glucosidase A, which are thought to proceed via SN1 and SN2 mechanisms, respectively.	Oxygen	55-61	solute carrier family 38 member 3	Homo sapiens	393-396
6788083-6	1981	The large magnitude of these KIEs requires that carbon-oxygen bond scission be far advanced in the transition states for these reactions; therefore in the transition states for the first irreversible steps in these reaction sequences, scission of the glycosidic bond must be essentially complete for the reactions catalyzed by lysozyme and beta-glucosidase A, which are thought to proceed via SN1 and SN2 mechanisms, respectively.	Oxygen	55-61	solute carrier family 38 member 5	Homo sapiens	401-404
7217086-6	1981	Strong support is provided by the structure of this porphyrin for our contention that the prosthetic heme of cytochrome P-450 is alkylated during attempted transfer of the catalytically-activated oxygen to the pi-bond of destructive unsaturated substrates.	Oxygen	196-202	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-125
7219526-6	1981	Activation of the oxidase is associated with the generation of various reduced oxygen species which have been widely thought to be responsible for the killing of phagocytosed microorganisms either directly, or by acting as substrates for myeloperoxidase-mediated halogenation.	Oxygen	79-85	myeloperoxidase	Homo sapiens	238-253
7333740-6	1981	Oxygen uptake and heart rate were relatively constant for each subject and averaged 0.94 l x min-1 and 110 beat x min-1 throughout exercise.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
7333740-6	1981	Oxygen uptake and heart rate were relatively constant for each subject and averaged 0.94 l x min-1 and 110 beat x min-1 throughout exercise.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	114-119
7297957-1	1981	Hemoglobin and cytochrome P-450 have in common heme structure (i.e. protoporphyrin (IX), binding ability to molecular oxygen or carbon monoxide and enzyme-like activity (i.e. aniline hydroxylation; J.B.C.	Oxygen	118-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	15-31
7238856-0	1981	Hemoglobin Saint Mande beta 102 (G4) asn replaced by tyr: a new low oxygen affinity variant.	Oxygen	68-74	chromosome 6 open reading frame 47	Homo sapiens	11-35
7238654-1	1981	A mathematical model for the control of erythropoiesis has been developed based on the balance between oxygen supply and demand at a renal oxygen detector which in turn controls erythropoietin release and red cell production.	Oxygen	103-109	erythropoietin	Homo sapiens	178-192
7018494-0	1981	Effects of O2 stress on tomato alcohol dehydrogenase activity: description of a second ADH coding genes.	Oxygen	11-13	alcohol dehydrogenase-like	Solanum lycopersicum	87-90
7238654-1	1981	A mathematical model for the control of erythropoiesis has been developed based on the balance between oxygen supply and demand at a renal oxygen detector which in turn controls erythropoietin release and red cell production.	Oxygen	139-145	erythropoietin	Homo sapiens	178-192
7212090-6	1981	Plasma AVP of conscious N rats was 2.7 +/- 0.40 pg/ml plasma during normoxia and 2.4 +/- 0.74 pg/ml plasma after 2 h of exposure to inspired O2 fractional concentrations of 0.105 (paired samples).	Oxygen	141-143	arginine vasopressin	Rattus norvegicus	7-10
6257719-9	1981	radical then reacts with oxygen to form superoxide, which ultimately reduces cytochrome c.	Oxygen	25-31	cytochrome c, somatic	Homo sapiens	77-89
6272737-4	1981	At these pH values the immediate product after oxygen addition is a species with a 605-606 nm absorption band, not identical with ferrous cytochrome a, but capable of oxidizing added cytochrome c.	Oxygen	47-53	cytochrome c, somatic	Homo sapiens	183-195
7282394-1	1981	The effect of exposure of rats to high concentrations of oxygen (90-95%, normobaric) on the activation of angiotensin I to angiotensin II and on the inactivation of bradykinin, prostaglandin E2 (PGE2) and 5-hydroxytryptamine (serotonin) in the pulmonary circulation of isolated perfused rat lungs was investigated.	Oxygen	57-63	angiotensinogen	Rattus norvegicus	123-137
6259208-3	1981	Production of superoxide anion (O2-) stimulated by concanavalin A or the chemotactic peptide formyl-methionyl-leucyl-phenylalanine FMLP was inhibited by DASA pretreatment, whereas O2- production stimulated by phorbol myristate acetate (PMA), sodium fluoride.	Oxygen	32-34	formyl peptide receptor 1	Homo sapiens	131-135
6259208-3	1981	Production of superoxide anion (O2-) stimulated by concanavalin A or the chemotactic peptide formyl-methionyl-leucyl-phenylalanine FMLP was inhibited by DASA pretreatment, whereas O2- production stimulated by phorbol myristate acetate (PMA), sodium fluoride.	Oxygen	180-182	formyl peptide receptor 1	Homo sapiens	131-135
7195007-9	1981	The facilitation of the oxygen transport by myoglobin was 50 to 100% of the maximum value to be expected on the basis of the prevailing myoglobin concentration.	Oxygen	24-30	myoglobin	Gallus gallus	44-53
7195007-9	1981	The facilitation of the oxygen transport by myoglobin was 50 to 100% of the maximum value to be expected on the basis of the prevailing myoglobin concentration.	Oxygen	24-30	myoglobin	Gallus gallus	136-145
6259208-5	1981	Pretreatment with DASA inhibited oxygen uptake stimulated by FMLP, but not oxygen uptake stimulated by PMA.	Oxygen	33-39	formyl peptide receptor 1	Homo sapiens	61-65
7195007-2	1981	We studied the steady-state oxygen transfer across thin layers of respiring chicken gizzard smooth muscle and compared three models for oxygen consumption with respect to their influence on the facilitation of oxygen diffusion by myoglobin.	Oxygen	136-142	myoglobin	Gallus gallus	230-239
7195007-2	1981	We studied the steady-state oxygen transfer across thin layers of respiring chicken gizzard smooth muscle and compared three models for oxygen consumption with respect to their influence on the facilitation of oxygen diffusion by myoglobin.	Oxygen	136-142	myoglobin	Gallus gallus	230-239
6257154-5	1981	The potential importance of enhanced O2 release by AM from cigarette smokers was confirmed by demonstrating that lysis of fibroblasts induced by AM from smokers was completely prevented by addition of SOD and catalase.	Oxygen	37-39	superoxide dismutase 1	Homo sapiens	201-204
6264975-6	1981	An addition of catalase results in liberation of some part of consumed oxygen, this being indicative of accumulation of hydrogen peroxide.	Oxygen	71-77	catalase	Homo sapiens	15-23
6257154-5	1981	The potential importance of enhanced O2 release by AM from cigarette smokers was confirmed by demonstrating that lysis of fibroblasts induced by AM from smokers was completely prevented by addition of SOD and catalase.	Oxygen	37-39	catalase	Homo sapiens	209-217
6978826-3	1981	Optimal IL-2 release was found at a low speed of stirring allowing circulation of the medium without suspending the agglutinated cells, and at an oxygen concentration of about 30-45% of saturation.	Oxygen	146-152	interleukin 2	Homo sapiens	8-12
7451651-5	1981	Progressive slowing of vasodilation followed angiotensin II-induced constriction as the lung oxygen tension fell progressively below 60 Torr.	Oxygen	93-99	angiotensinogen	Rattus norvegicus	45-59
6287508-2	1981	Effect of pressure on activities of O-(2)-producing enzyme xanthine oxidase (XO) and O-(2)-scavenging enzyme superoxide dismutase (SOD) has been investigated to 1000 bar.	Oxygen	36-41	superoxide dismutase 1	Homo sapiens	109-129
6260172-2	1981	The relative effectiveness of oxidizing (.OH, H2O2), ambivalent (O2-) and reducing free radicals (e- and CO2-) in causing damage to membranes and membrane=bound glyceraldehyde-3-phosphate dehydrogenase of resealed erythrocyte ghosts has been determined.	Oxygen	48-50	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	161-201
7339635-2	1981	The effect of pressure on the catalytic decomposition of hydrogen peroxide by catalase has been investigated to 1000 bar by spectrophotometry and oxygen polarography.	Oxygen	146-152	catalase	Homo sapiens	78-86
6287508-2	1981	Effect of pressure on activities of O-(2)-producing enzyme xanthine oxidase (XO) and O-(2)-scavenging enzyme superoxide dismutase (SOD) has been investigated to 1000 bar.	Oxygen	36-41	superoxide dismutase 1	Homo sapiens	131-134
6287508-2	1981	Effect of pressure on activities of O-(2)-producing enzyme xanthine oxidase (XO) and O-(2)-scavenging enzyme superoxide dismutase (SOD) has been investigated to 1000 bar.	Oxygen	85-90	superoxide dismutase 1	Homo sapiens	109-129
6287508-2	1981	Effect of pressure on activities of O-(2)-producing enzyme xanthine oxidase (XO) and O-(2)-scavenging enzyme superoxide dismutase (SOD) has been investigated to 1000 bar.	Oxygen	85-90	superoxide dismutase 1	Homo sapiens	131-134
6287508-3	1981	Methods used included spectrophotometric determinations of inhibition by SOD of O-(2)-induced reduction of cytochrome c and oxidation of ascorbic acids.	Oxygen	80-85	superoxide dismutase 1	Homo sapiens	73-76
6287508-3	1981	Methods used included spectrophotometric determinations of inhibition by SOD of O-(2)-induced reduction of cytochrome c and oxidation of ascorbic acids.	Oxygen	80-85	cytochrome c, somatic	Homo sapiens	107-119
7448097-2	1980	We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	34-37
7461137-0	1980	A possible role for Ca2+ in thyroid hormone-dependent oxygen consumption in skeletal muscle of the rat.	Oxygen	54-60	carbonic anhydrase 2	Rattus norvegicus	20-23
6253331-1	1980	Induction of two forms of superoxide dismutase, catalase and glutathione peroxidase, occurs very rapidly in neonatal rat lung tissue upon exposure of these animals to 94 + % normobaric oxygen.	Oxygen	185-191	catalase	Rattus norvegicus	48-56
6253331-6	1980	These data have formed the basis of the proposal that oxygen induction of the superoxide dismutases catalase and glutathione peroxidase provides a vital part of the defense mechanism against oxygen toxicity.	Oxygen	54-60	catalase	Rattus norvegicus	100-108
6253331-6	1980	These data have formed the basis of the proposal that oxygen induction of the superoxide dismutases catalase and glutathione peroxidase provides a vital part of the defense mechanism against oxygen toxicity.	Oxygen	191-197	catalase	Rattus norvegicus	100-108
6893656-5	1980	In addition, toxic oxygen species, such as superoxide, that are produced by granulocytes that have been triggered by C5a can damage the endothelium, an event that may, if it occurs in the lungs, contribute to the development of the adult respiratory distress syndrome (ARDS).	Oxygen	19-25	complement C5a receptor 1	Homo sapiens	117-120
7224588-6	1980	Lastly, this O2(-) production triggered by anti-H-2 antibodies should be kept in mind when discussing the mechanism of vascular damage in allograft rejection.	Oxygen	13-15	histocompatibility-2, MHC	Mus musculus	48-51
7193215-6	1980	Catalase, cytochrome C, histidine, and methionine inhibited the PMA-induced 51Cr-release by human neutrophils, whereas superoxide dismutase, myeloperoxidase inhibitors, and some hydroxyl radical scavengers or singlet oxygen quenchers had no effect.	Oxygen	217-223	catalase	Homo sapiens	0-8
7448097-2	1980	We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule.	Oxygen	132-138	nuclear factor kappa B subunit 1	Homo sapiens	34-37
7191648-7	1980	Values for P50 for mixed venous and coronary sinus blood were calculated from O2 tension and saturation.	Oxygen	78-80	nuclear factor kappa B subunit 1	Homo sapiens	11-14
6773745-2	1980	This activity employs cytochrome P-450 as an oxygen donor.	Oxygen	45-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-38
7410388-2	1980	the rdical was found to be reoxidized readily by molecular oxygen, with a rate constant of 4 x 10(5) M-1 min-1 at pH 7.0, 25 degrees C. On mixing the radical under anaerobic conditions with pyruvate, a change in spectrum typical of charge transfer interaction was found.	Oxygen	59-65	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
7435577-7	1980	Fetal oxygen consumption increased 28% to 10.5 +/- 0.5 from 8.2 +/- 1.1 ml x min-1 x kg-1.	Oxygen	6-12	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
6254418-2	1980	Enzymes that potentiate (such as peroxidase) or limit (such as catalase, superoxide dismutase) the toxicity of these agents contribute to the complexity of the oxygen-dependent antimicrobial systems of phagocytes.	Oxygen	160-166	catalase	Homo sapiens	63-71
7429608-6	1980	Negative results obtained with scavengers of hydroxyl radicals and singlet molecular oxygen suggest that protection of superoxide dismutase by catalase from inactivation by hydrogen peroxide, is a likely explanation for the observed potentiation.	Oxygen	85-91	catalase	Rattus norvegicus	143-151
6776974-3	1980	The low-flow system delivered 2 litre min-1 of dry oxygen into the nasopharynx through a catheter.	Oxygen	51-57	CD59 molecule (CD59 blood group)	Homo sapiens	38-43
7213348-6	1980	Super-reduced Hipip is reoxidized with O2, rate constant 4.8 x 10(6) M-1 .	Oxygen	39-41	myoregulin	Homo sapiens	69-72
6249302-0	1980	Significance of O2 availability and cycling on the respiratory burst response of human PMN"s exposed to cytochrome c and superoxide dismutase.	Oxygen	16-18	cytochrome c, somatic	Homo sapiens	104-116
7008486-9	1980	The observations also suggest that, in these patients, CPAP levels exceeding 10 cmH2O bring about cardiac depression leading to an undesirable reduction in systemic oxygen transport.	Oxygen	165-171	troponin T2, cardiac type	Homo sapiens	80-84
16398027-3	1980	However, diabetes did produce complex changes in hemoglobin-oxygen releasing capacity which were compensated for in the expected way, i.e. oxygen releasing capacity showed an inverse correlation with erythropoietin.	Oxygen	60-66	erythropoietin	Homo sapiens	200-214
16398027-3	1980	However, diabetes did produce complex changes in hemoglobin-oxygen releasing capacity which were compensated for in the expected way, i.e. oxygen releasing capacity showed an inverse correlation with erythropoietin.	Oxygen	139-145	erythropoietin	Homo sapiens	200-214
7414619-1	1980	Exposure of rats to a reduced oxygen tension (6% O2, 94% N2) for 6 h increased the serum enzyme and the histological lesions induced by carbon tetrachloride (CCl4).	Oxygen	30-36	C-C motif chemokine ligand 4	Rattus norvegicus	158-162
7414619-1	1980	Exposure of rats to a reduced oxygen tension (6% O2, 94% N2) for 6 h increased the serum enzyme and the histological lesions induced by carbon tetrachloride (CCl4).	Oxygen	49-51	C-C motif chemokine ligand 4	Rattus norvegicus	158-162
7392899-4	1980	Maximum oxygen consumption averaged 45.2 ml/kg min-1 when the subjects were considered as a single group.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	47-52
6245106-7	1980	)Endotoxin-treated animals in O(2) showed increases in pulmonary superoxide dismutase, catalase, and glutathione peroxidase activities before the usual time of onset of measurable pulmonary edema in untreated animals in O(2).	Oxygen	30-34	catalase	Rattus norvegicus	87-95
7377315-5	1980	If the same concentration of vasoactive intestinal polypeptide was administered following hypertonic opening of the blood-brain barrier, cerebral blood flow and oxygen consumption were both elevated (by 37 +/- 7% and 28 +/- 10%, respectively), accompanied by increased EEG activity.	Oxygen	161-167	vasoactive intestinal peptide	Rattus norvegicus	29-62
7379213-5	1980	The finding that singlet oxygen will oxidise a cell constituent into a powerful inducer is compatible with the hypothesis that excited states of oxygen and their oxidation products may play a central role in the induction of cytochrome P-450 and associated enzyme activities by many chemically unrelated inducers.	Oxygen	25-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	225-241
7466845-0	1980	Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo.	Oxygen	0-6	C-C motif chemokine ligand 4	Rattus norvegicus	21-25
7385238-0	1980	Effects of superoxide dismutase and catalase on central nervous system toxicity of hyperbaric oxygen.	Oxygen	94-100	catalase	Homo sapiens	36-44
6243971-0	1980	Reduction of oxygen-pulsed cytochrome c oxidase by cytochrome c and other electron donors.	Oxygen	13-19	cytochrome c, somatic	Homo sapiens	27-39
6243971-0	1980	Reduction of oxygen-pulsed cytochrome c oxidase by cytochrome c and other electron donors.	Oxygen	13-19	cytochrome c, somatic	Homo sapiens	51-63
6243971-3	1980	Cytochrome c oxidase present in the dithionite-containing syringe is fully oxidized within the mixing time and the oxygen-pulsed form of the oxidase is produced.	Oxygen	115-121	cytochrome c, somatic	Homo sapiens	0-12
6929480-0	1980	Chemical mechanisms for cytochrome P-450 hydroxylation: evidence for acylation of heme-bound dioxygen.	Oxygen	93-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-40
6929480-1	1980	Using isotopic tracer methods, we have shown that dihydrolipoic acid (2,3-thioctic acid) acylates the distal oxygen of ferrous oxygenated Pseudomonas cytochrome P-450, forming a transient acyl peroxide intermediate that facilitates oxygen-oxygen bond cleavage.	Oxygen	109-115	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-166
7363899-1	1980	Exposure of rats to a 50% N2O/oxygen mixture led to a rapid loss of methionine synthase activity in both liver and brain.	Oxygen	30-36	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	68-87
6929480-1	1980	Using isotopic tracer methods, we have shown that dihydrolipoic acid (2,3-thioctic acid) acylates the distal oxygen of ferrous oxygenated Pseudomonas cytochrome P-450, forming a transient acyl peroxide intermediate that facilitates oxygen-oxygen bond cleavage.	Oxygen	127-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-166
6929480-1	1980	Using isotopic tracer methods, we have shown that dihydrolipoic acid (2,3-thioctic acid) acylates the distal oxygen of ferrous oxygenated Pseudomonas cytochrome P-450, forming a transient acyl peroxide intermediate that facilitates oxygen-oxygen bond cleavage.	Oxygen	127-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-166
7466845-1	1980	Rat liver microsomes showed an atypical oxygen dependence of carbon tetrachloride (CCL4)-induced malondialdehyde formation with a maximum at ca.	Oxygen	40-46	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
7466845-4	1980	Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations.	Oxygen	54-60	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
7466845-4	1980	Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations.	Oxygen	102-108	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
7466845-5	1980	The initiation of CCl4-induced lipid peroxidation in the liver would appear to be influenced by the oxygen concentrations present in the hepatocytes.	Oxygen	100-106	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
6243968-2	1980	The steady-state oxidation of ferrocytochrome c by dioxygen catalyzed by cytochrome c oxidase, is inhibited non-competitively towards cytochrome c by methanethiol, ethanethiol, 1-propanethiol and 1-butanethiol with Ki values of 4.5, 91, 200 and 330 microM, respectively.	Oxygen	51-59	cytochrome c, somatic	Homo sapiens	35-47
6243968-2	1980	The steady-state oxidation of ferrocytochrome c by dioxygen catalyzed by cytochrome c oxidase, is inhibited non-competitively towards cytochrome c by methanethiol, ethanethiol, 1-propanethiol and 1-butanethiol with Ki values of 4.5, 91, 200 and 330 microM, respectively.	Oxygen	51-59	cytochrome c, somatic	Homo sapiens	73-85
7188697-1	1980	The chain oxidation of glyceraldehyde-3-phosphate dehydrogenase.NADH by perhydroxyl radicals and propagated by molecular oxygen was studied by the xanthine-xanthine oxidase system, 60Co gamma-ray, and pulse radiolysis.	Oxygen	121-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	23-63
6989357-4	1980	Inhibition of enhanced oxygen uptake by KCN (2mM) and 4-methylpyrazole (0.8 mM) suggested the involvement of the mitochondrial respiratory chain and alcohol dehydrogenase in this phenomenon.	Oxygen	23-29	aldo-keto reductase family 1 member A1	Rattus norvegicus	149-170
7188697-4	1980	Rate studies as a function of pH indicate that O2- is unreactive toward the glyceraldehyde-3-phosphate dehydrogenase.NADH complex.	Oxygen	47-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	76-116
6101617-1	1980	Prior exposure of rats to a mixture of nitrous oxide/oxygen (80/20) for 20 to 24 hours and feeding rats a diet deficient in vitamin B-12 and methionine for 23 weeks resulted in a 86 to 90% decrease in the activity of the vitamin B-12 dependent enzyme, 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 4.2.99.10).	Oxygen	53-59	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	252-307
6996140-8	1980	On multiple regression analysis the increase in serum insulin with rise in socio-economic status was independent of age and body mass index and was dependent on the indirect effect of maximum volume of oxygen intake.	Oxygen	202-208	insulin	Homo sapiens	54-61
6250983-1	1980	Studies were carried out of the effects of prolactin (0.5-1.0 mU) and 3"5" dibutyryl cyclic AMP -(dbcAMP) (100-500 ng) on oxygen uptake and (U-14C) glucose and (1-14C) acetate utilization by human spermatozoa.	Oxygen	122-128	prolactin	Homo sapiens	43-52
7356613-3	1980	The peroxidase-catalyzed transfer of oxygen atoms from 15-hydroperoxyprostaglandin E2 (15-HPE2) to sulindac sulfide was examined using [18O]15-HPE2 which was prepared enzymatically and analyzed mass spectrometrically.	Oxygen	37-43	SIX homeobox 3	Homo sapiens	90-94
7356613-3	1980	The peroxidase-catalyzed transfer of oxygen atoms from 15-hydroperoxyprostaglandin E2 (15-HPE2) to sulindac sulfide was examined using [18O]15-HPE2 which was prepared enzymatically and analyzed mass spectrometrically.	Oxygen	37-43	SIX homeobox 3	Homo sapiens	143-147
7356613-4	1980	The sulfoxide resulting from sulindac sulfide oxidation was also analyzed mass spectrometrically and found to possess an oxygen atom arising exclusively from the 15-HPE2.	Oxygen	121-127	SIX homeobox 3	Homo sapiens	165-169
6258882-8	1980	Oxygen tension thus regulates converting enzyme activity and hence the circulating levels of angiotensin II and bradykinin.	Oxygen	0-6	kininogen 1	Canis lupus familiaris	112-122
7005063-6	1980	Isolated islets maintained for seven days in tissue culture at a glucose concentration of 5.5 mM showed a pronounced increase in oxygen consumption when they were incubated with the nonmetabolizable insulin secretagogue b (+/-) BCH in the absence of glucose.	Oxygen	129-135	chimerin 2	Mus musculus	228-231
7350246-2	1980	Priming with LPS (1 microgram/ml) produced a sevenfold enhancement of PMA-stimulated O2- generation; priming was detected within 30 min and persisted for at least 4 d. Exposure to MDP (1 muM) primed the macrophages to double their O2- release; the response was first observed after 4 h and persisted for at least 3 d. The priming response was not observed with stereoisomers of MDP, which are inactive as adjuvants.	Oxygen	85-87	toll-like receptor 4	Mus musculus	13-16
7350246-2	1980	Priming with LPS (1 microgram/ml) produced a sevenfold enhancement of PMA-stimulated O2- generation; priming was detected within 30 min and persisted for at least 4 d. Exposure to MDP (1 muM) primed the macrophages to double their O2- release; the response was first observed after 4 h and persisted for at least 3 d. The priming response was not observed with stereoisomers of MDP, which are inactive as adjuvants.	Oxygen	231-233	toll-like receptor 4	Mus musculus	13-16
7350246-6	1980	(d) The macrophage-like cell line J774.1 also showed enhanced O2--generating capacity after a 4-h exposure to LPS or MDP.	Oxygen	62-64	toll-like receptor 4	Mus musculus	110-113
7423531-0	1980	Adaptation to hyperoxia in the neonatal rat: kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase.	Oxygen	71-77	catalase	Rattus norvegicus	128-136
6761138-3	1980	Among these mechanisms is the feedback circuit which, triggered by an intracellular decrease in oxygen supply, initiates the production of a polypeptide hormone, erythropoietin, which in turn augments the production of an oxygen carrier, the hemoglobin-containing red cell.	Oxygen	96-102	erythropoietin	Homo sapiens	162-176
6761138-3	1980	Among these mechanisms is the feedback circuit which, triggered by an intracellular decrease in oxygen supply, initiates the production of a polypeptide hormone, erythropoietin, which in turn augments the production of an oxygen carrier, the hemoglobin-containing red cell.	Oxygen	222-228	erythropoietin	Homo sapiens	162-176
6767183-4	1980	DES is capable of SN1 alkylations as well as SN2 and thereby causes some alkylation on oxygen sites including the O6-position of guanine which is thought to be significant in mutagenesis by direct mispairing.	Oxygen	87-93	solute carrier family 38 member 3	Homo sapiens	18-21
6767183-4	1980	DES is capable of SN1 alkylations as well as SN2 and thereby causes some alkylation on oxygen sites including the O6-position of guanine which is thought to be significant in mutagenesis by direct mispairing.	Oxygen	87-93	solute carrier family 38 member 5	Homo sapiens	45-48
228731-3	1979	However, when oxygen depletion was slowed or prevented by working at lower concentrations of xanthine oxidase, at lower temperatures or by vigorous agitation under an atmosphere of 100% oxygen, superoxide dismutase or catalase protected markedly when added separately and protected almost completely when added together.	Oxygen	14-20	catalase	Homo sapiens	218-226
40970-2	1979	In the presence of valinomycin, 2 K+ ions were taken up by the vesicles per electron transferred from cytochrome c to oxygen.	Oxygen	118-124	cytochrome c, somatic	Homo sapiens	102-114
161837-1	1979	During the irradiation of aqueous solution of insulin (pH 1.8) the decrease of original insulin molecules and the formation of radiation aggregates of insulin was studied in dependence on the concentration of irradiation solution, on the doses and conditions of irradiation (oxygenated and oxygen-free atmosphere, the presence of t-butanol, addition of [14C]amino acids).	Oxygen	275-281	insulin	Homo sapiens	46-53
514085-1	1979	Oxygen consumption by circulating lymphocytes of children with isolated growth hormone deficiency was studied before and 6 mo after the start of growth hormone therapy.	Oxygen	0-6	growth hormone 1	Homo sapiens	72-86
42873-6	1979	As P50 decreased from 25 to 10 mm Hg, coronary sinus PO2 (PcsO2) diminished from 26 +/- 2 to 18 +/- 2 mm Hg (-29 +/- 2%), coronary sinus O2 content (CcsO2) increased by 15 +/- 3%, myocardial oxygen consumption did not change significantly.	Oxygen	54-56	nuclear factor kappa B subunit 1	Homo sapiens	3-6
229842-1	1979	Another look at the effect of cytochrome c on oxygen uptake by stimulated neutrophils.	Oxygen	46-52	cytochrome c, somatic	Homo sapiens	30-42
484628-6	1979	These results for SOD activity suggest that the oxygen requirement in the placenta at early stages of gestation is low compared with that at the end of gestation.	Oxygen	48-54	superoxide dismutase 1	Homo sapiens	18-21
484893-8	1979	These results support the authors" hypothesis that halothane is metabolized to hepatotoxic intermediates by a reductive or non-oxygen-dependent cytochrome P-450-dependent pathway.	Oxygen	127-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160
527719-0	1979	[Effect of a decrease in the partial pressure of oxygen on the electrophysiologic properties of grape snail neurons].	Oxygen	49-55	snail family transcriptional repressor 1	Homo sapiens	102-107
508978-6	1979	min-1, below which oxygen consumption falls dramatically.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
36390-1	1979	Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides.	Oxygen	29-35	carbonic anhydrase 2	Rattus norvegicus	127-130
575296-8	1979	The increase in relative leghemoglobin a content suggests that leghemoglobin a might be required for regulation of nodule O2 concentration only when the nodule structure is complex.	Oxygen	122-124	leghemoglobin A	Glycine max	63-76
39762-3	1979	Under 1 atm pressure (100 kPa) butene decreased the affinity of hemoglobin (Hb) for oxygen (p50) by 45% without altering the cooperativity of ligand binding.	Oxygen	84-90	nuclear factor kappa B subunit 1	Homo sapiens	92-95
36390-1	1979	Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides.	Oxygen	29-35	carbonic anhydrase 2	Rattus norvegicus	127-130
113222-4	1979	Hydrogen peroxide production (r = 0.988), nitroblue tetrazolium reduction (r = 0.969) and cytochrome c reduction (r = 0.862) were more reliably correlated to oxygen-uptake than to ingestion rate, and iodination was better related to hydrogen peroxide production (r = 0.90 and 0.819 for 100 and 20 micromol/l iodide respectively) than to ingestion rate.	Oxygen	158-164	cytochrome c, somatic	Homo sapiens	90-102
223635-1	1979	Cytochrome c requirement for oxygen uptake.	Oxygen	29-35	cytochrome c, somatic	Homo sapiens	0-12
223635-8	1979	A model is proposed to explain these findings in which a high-affinity site for cytochrome c on the oxidase regulates the access of hydrophilic electron donors to a low-affinity site, and reduction via the high-affinity site is required for continuous oxygen uptake.	Oxygen	252-258	cytochrome c, somatic	Homo sapiens	80-92
16345376-5	1979	The uptake of histidine as analyzed through the measurement of oxygen uptake rates was characterized by a saturation constant of 1.7 to 10.5 muM histidine; the maximum uptake rate was always greater than the actual histidine uptake rate in the culture.	Oxygen	63-69	latexin	Homo sapiens	141-144
34418-4	1979	The effect of 2,3-DPG on the position of the OEC (p50, the pO2 at one-half maximal O2 saturation) is via its allosteric effect on haemoglobin at 2,3-DPG/haemoglobin less than 1.	Oxygen	60-62	nuclear factor kappa B subunit 1	Homo sapiens	50-53
452489-2	1979	On the basis of the data published in the literature, hypoxic inhibition of the enzyme appears to be the significant reason for the posthypoxic activation of synglete-oxygen pathway of lipid peroxidation in tissues, enriched with catalase [liver, kidney, blood ] as well as of hydroxyl-radical pathway of peroxidation in tissues with the low catalase activity [brain, heart, lungs].	Oxygen	167-173	catalase	Rattus norvegicus	230-238
452489-2	1979	On the basis of the data published in the literature, hypoxic inhibition of the enzyme appears to be the significant reason for the posthypoxic activation of synglete-oxygen pathway of lipid peroxidation in tissues, enriched with catalase [liver, kidney, blood ] as well as of hydroxyl-radical pathway of peroxidation in tissues with the low catalase activity [brain, heart, lungs].	Oxygen	167-173	catalase	Rattus norvegicus	342-350
36161-6	1979	Optimum activity occurs sharply at pH 6.1 and the Michaelis constant for glycolate was 6.3.10(-5)M. Molecular oxygen does not appear to be the electron acceptor and no requirement for cofactors has been demonstrated, althoug flavin mononucleotide, ascorbate and cytochrome c stimulate activity.	Oxygen	110-116	cytochrome c, somatic	Homo sapiens	262-274
400564-6	1979	A decrease in red-cell oxygen release was noted in some untreated nonacidotic diabetics, and an adverse effect of insulin on the oxygen release capacity was demonstrated in both newly diagnosed ketoacidotic and nonacidotic diabetics.	Oxygen	129-135	insulin	Homo sapiens	114-121
420819-1	1979	The mechanism of cytochrome P-450 catalyzed steroid hydroxylations in rat liver microsomes has been investigated by employing derivatives of iodosylbenzene as oxygen donors.	Oxygen	159-165	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-33
420819-5	1979	The capacity of the oxidation agents to serve as oxygen donors in cytochrome P-450 dependent steroid hydroxylation is probably dependent upon several factors such as the tendency of iodosyl compounds to associate, which decreases coordination with the heme iron, the presence of bulky substituents in the 2 position (decreases association), and the presence of electron-withdrawing substituents (tends to decrease coordination with the heme iron).	Oxygen	49-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
443898-0	1979	The effect of vasopressin on oxygen availability.	Oxygen	29-35	arginine vasopressin	Homo sapiens	14-25
443898-10	1979	This study demonstrated that a vasopressin infusion causes a marked decrease in oxygen availability due primarily to a decreased stroke volume and, to a lesser extent during the first hour, to a decreased heart rate.	Oxygen	80-86	arginine vasopressin	Homo sapiens	31-42
443898-13	1979	It is suggested that until the effect of vasopressin on the cardiopulmonary systems and hence oxygen availability is fully studied in critically ill patients, that it be used with caution and with appropriate hemodynamic monitoring.	Oxygen	94-100	arginine vasopressin	Homo sapiens	41-52
223025-7	1979	These effects are important from the point of view that the primary role of the heme of cytochrome P450 is the activation of molecular oxygen.	Oxygen	135-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	88-103
420819-0	1979	Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylations.	Oxygen	30-36	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	47-63
517008-0	1979	Quantum chemical interpretation of the spectral properties of the CO and O2 complexes of hemoglobin and cytochrome P-450.	Oxygen	73-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	104-120
217854-7	1979	During acute hypoxia, venous bradykinin will pass through the lung unmetabolized, and local levels of angiotensin II and bradykinin will vary in vascular beds with different oxygen tensions, providing a finely-graded mechanism for blood flow regulation.	Oxygen	174-180	kininogen 1	Canis lupus familiaris	121-131
42252-0	1979	Electrochemical investigations on the oxygen activation by cytochrome P-450.	Oxygen	38-44	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-75
42252-7	1979	In contrast the cytochrome P-450 catalyzed NADPH-dependent reaction with the same substrate gives corticosterone, O2- represents only an intermediate in the activation of oxygen and is not the "activated oxygen" species.	Oxygen	114-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-32
42252-7	1979	In contrast the cytochrome P-450 catalyzed NADPH-dependent reaction with the same substrate gives corticosterone, O2- represents only an intermediate in the activation of oxygen and is not the "activated oxygen" species.	Oxygen	171-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-32
42252-9	1979	The interaction of adsorbed cytochrome P-450 on the electrode surface with the reduced oxygen species in the absence of NADPH was studied.	Oxygen	87-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-44
42252-12	1979	In a model of electro-enzyme-reactor several substrates were hydroxylated by microsomal cytochrome P-450 with cathodically reduced oxygen which substitutes NADPH.	Oxygen	131-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	88-104
517008-1	1979	The electronic transitions of CO and O2 complexes of hemoglobin and cytochrome P-450 were calculated using a PPP method extended for metal complexes.	Oxygen	37-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-84
552903-6	1979	(3) H2O2 was shown to be the only relevant oxygen derivative in the production of cell damage: catalase was the only externally added agent that protected sensitive cells, and H2O2 (congruent to 10(-3) M) had the same effects as the photochemical treatment.	Oxygen	43-49	catalase	Rattus norvegicus	95-103
44990-4	1979	The increase of the hemoglobin oxygen affinity, associated with a decrease of the 2,3-DPG level appears to be very fast in the samples of ACD stored blood since two hours after sampling, the P50 decrease was of 4 torr.	Oxygen	31-37	nuclear factor kappa B subunit 1	Homo sapiens	191-194
547738-3	1979	These apparatuses were used to measure oxygen affinity, ie P50, in anemic children with malignant disease prior to treatment and in children undergoing therapy.	Oxygen	39-45	nuclear factor kappa B subunit 1	Homo sapiens	59-62
547738-6	1979	However, when oxygen affinity and 2,3-DPG levels were measured in anemic patients receiving treatment, three types of response to anemia were noted: 1) increased P50 and 2,3-DPG; 2) normal or low P50 and 2,3-DPG, and; 3) normal or low P50 with increased 2,3-DPG.	Oxygen	14-20	nuclear factor kappa B subunit 1	Homo sapiens	162-165
93746-8	1979	Illumination of eosin-labeled ghosts causes a rapid loss of acetylcholinesterase activity but this can be prevented by prior displacement of oxygen in the sample by argon.	Oxygen	141-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
154917-2	1978	At preset oxygen flow rates of less than 1 litre min-1 unacceptable errors were found.	Oxygen	10-16	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
27230-0	1978	Oxygen equilibrium analyses of isolated hemoglobins A2, Lepore-Washington and P-nilotic.	Oxygen	0-6	glycoprotein hormone subunit alpha 2	Homo sapiens	52-54
214425-4	1978	Based on these results, we propose that the oxidation of tetrahydropterin to quinonoid dihydropterin proceeds via two steps: tetrahydropterin is first oxidized by ferri-cytochrome c to give a pterin intermediate, which has lost one electron, then in turn this reduces O2 to form O2-.	Oxygen	268-270	cytochrome c, somatic	Homo sapiens	169-181
214425-4	1978	Based on these results, we propose that the oxidation of tetrahydropterin to quinonoid dihydropterin proceeds via two steps: tetrahydropterin is first oxidized by ferri-cytochrome c to give a pterin intermediate, which has lost one electron, then in turn this reduces O2 to form O2-.	Oxygen	279-281	cytochrome c, somatic	Homo sapiens	169-181
27696-0	1978	An adverse effect of insulin on the oxygen-release capacity of red blood cells in nonacidotic diabetics.	Oxygen	36-42	insulin	Homo sapiens	21-28
27696-5	1978	The study indicates that insulin administration to diabetics with high blood glucose levels may lead to transient decreases in red cell 2,3-DPG and in oxygen-releasing capacity of the red blood cells.	Oxygen	151-157	insulin	Homo sapiens	25-32
746499-7	1978	Inspiration of pure oxygen lowered the resting pressure by a mean of 3.2 mmHg but only decreased sPAP/work rate by 9%.	Oxygen	20-26	PDZK1 interacting protein 1	Homo sapiens	97-101
216472-5	1978	Incubation of the semiquinone from mitomycin C, mitomycin B, or streptonigrin (SN) with catalase or with superoxide dismutase inhibits the generation of OH, implying the intermediacy of H2O2 and O2 in its formation.	Oxygen	188-190	catalase	Homo sapiens	88-96
30478-5	1978	Comparison of the initial rates of proton ejection and oxidation of cytochrome c yields a H+/e- quotient close to 1.0 both in cytochrome c and oxygen pulse experiments.	Oxygen	143-149	cytochrome c, somatic	Homo sapiens	68-80
212271-12	1978	Inhibitory effects of both superoxide dismutase and catalase in oxygen-dependent reactions need not necessarily indicate the participation of the "Haber-Weiss" reaction.	Oxygen	64-70	catalase	Homo sapiens	52-60
27230-1	1978	Oxygen equilibrium studies have been carried out on hemoglobins A2 (alpha2delta2), Lepore-Washington (alpha2(deltabeta)2) and P-Nilotic (alpha2(beta2delta)2) using the beta chain containing hemoglobins A and S as controls.	Oxygen	0-6	glycoprotein hormone subunit alpha 2	Homo sapiens	64-66
27230-1	1978	Oxygen equilibrium studies have been carried out on hemoglobins A2 (alpha2delta2), Lepore-Washington (alpha2(deltabeta)2) and P-Nilotic (alpha2(beta2delta)2) using the beta chain containing hemoglobins A and S as controls.	Oxygen	0-6	glycoprotein hormone subunit alpha 2	Homo sapiens	68-80
27230-2	1978	This investigation was initiated mainly because of controversial data that have been published on the oxygen affinity of hemoglobin (Hb) A2 and because samples containing the rare Hb P-Nilotic became available.	Oxygen	102-108	glycoprotein hormone subunit alpha 2	Homo sapiens	137-139
687384-0	1978	Differential oxygen utilization in the stomach during vasopressin and tourniquet ischemia.	Oxygen	13-19	arginine vasopressin	Homo sapiens	54-65
686330-7	1978	The calculated P50 (partial pressure of oxygen at which there was 50% saturation of haemoglobin) decreased by 1.2 mmHg.	Oxygen	40-46	nuclear factor kappa B subunit 1	Homo sapiens	15-18
97275-7	1978	The appearance of the oxygenated form with the addition of hydrogen peroxide was probably due to the reaction of the reduced cytochrome with the oxygen that had evolved by the action of catalase present in the cells.	Oxygen	22-28	catalase	Homo sapiens	186-194
352331-0	1978	Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity.	Oxygen	69-75	4-aminobutyrate aminotransferase	Rattus norvegicus	15-32
28474-0	1978	Inhibition of azoreductase by oxygen.	Oxygen	30-36	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-26
225142-9	1978	The MPO-independent antimicrobial systems may be oxygen-dependent or oxygen-independent.	Oxygen	49-55	myeloperoxidase	Homo sapiens	4-7
225142-9	1978	The MPO-independent antimicrobial systems may be oxygen-dependent or oxygen-independent.	Oxygen	69-75	myeloperoxidase	Homo sapiens	4-7
670016-4	1978	The oxygen consumption (51.6 and 59.7 ml.min-1.kg-1 BW) for 55-kg load (at 4.09 and 4.64 km.h-1) possibly reached maximal aerobic capacity.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	41-46
98186-0	1978	Polychlorinated dibenzofuran (PCDF) formation from PCB mixture by heat and oxygen.	Oxygen	75-81	pyruvate carboxylase	Homo sapiens	51-54
206545-0	1978	Studies of the oxygen binding site of cytochrome P-450.	Oxygen	15-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-54
28182-5	1978	It is suggested that trichlorofluoromethane interacts with the reduced form of cytochrome P-450 at the oxygen binding site and a possible mechanism for its subsequent reductive dechlorination is proposed.	Oxygen	103-109	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	79-95
207730-5	1978	Exposure to zymosan under conditions in which the myeloperoxidase system was inactive (i.e., in the presence of myeloperoxidase inhibitors, or in the absence of oxygen) resulted in a substantial increase in the initial O(2) (-)-forming activity of particles from the zymosan-treated cells, but did not prevent the sharp fall in activity seen when zymosan exposure exceeded 10 min.	Oxygen	219-225	myeloperoxidase	Homo sapiens	50-65
207317-1	1978	Reaction kinetics of the reduction of O2 by cytochrome oxidase follow essentially the same rate equation as that proposed for the oxidation of cytochrome c.	Oxygen	38-40	cytochrome c, somatic	Homo sapiens	143-155
25310-7	1978	Oxygen binding to hemoglobin was lower in patients with the lowest OFIa--and therefore, at in vivo conditions of pH, PCO2, and temperature, P50 in vivo was higher.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	140-143
656439-6	1978	The oxidation occurred in a range of the catalase-H2O2 reaction where the evolution of oxygen could be excluded.	Oxygen	87-93	catalase	Homo sapiens	41-49
25310-9	1978	An alternative interpretation is that a high P50 in vivo minimizes the reduction in PVO2 needed to maintain VO2 when increased proportional extraction of O2 compensates for decreased OFIa.	Oxygen	86-88	nuclear factor kappa B subunit 1	Homo sapiens	45-48
204293-7	1978	In particular the kinetics of the reaction of cytochrome cr and cytochrome cn (native) with ascorbate, ferrocyanide-ferricyanide, O2 and cytochrome c oxidase were investigated in considerable detail.	Oxygen	130-132	cytochrome c, somatic	Homo sapiens	46-58
76024-3	1978	Ventilation of the lungs with air or oxygen causes the release of bradykinin which is rapidly inactivated in the lungs.	Oxygen	37-43	kininogen 1	Homo sapiens	66-76
76024-6	1978	Formation of bradykinin by granulocytes is critically dependent on the local oxygen tension.	Oxygen	77-83	kininogen 1	Homo sapiens	13-23
25655-3	1978	Cytochrome c and partially purified cytochrome P-450 from rat liver microsomal preparations activated the system in either O2 or H2O2.	Oxygen	123-125	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
618877-2	1978	Oxygen equilibrium curves determined by an automatic apparatus in 0.1 M potassium phosphate buffer, pH 7.0, at 20 degrees showed that the p50 was 5.8 mm Hg for Hb Lepore Boston, in contrast to 8.1 and 10.3 mm Hg for Hb A2 and Hb A, respectively.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	138-141
621277-1	1978	The action of histamine, carbamylcholine, and gastrin on oxygen uptake by cells isolated from canine fundic mucosa was studied in vitro.	Oxygen	57-63	gastrin	Canis lupus familiaris	46-53
223580-4	1978	The ACTH 4--9 analog H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) has behavioral activity after oral administration.	Oxygen	27-29	proopiomelanocortin	Homo sapiens	4-8
606304-4	1977	Haemoglobin concentration and P50 value would represent an adaptative mechanism to hypoxia: when hypoxia is moderate (80 greater than PaO2 greater than or equal to 65 torr) and isolated, oxygen haemoglobin affinity decreases (P50 increases); when hypoxia is severe (PaO2 less than 65 torr) and combined with hypercapnia and disturbed acid-base equilibrium, P50 comes back to normal range but haemoglobin increases, restoring thus, the normal blood oxygen content.	Oxygen	187-193	nuclear factor kappa B subunit 1	Homo sapiens	30-33
676298-2	1978	With the progressive cycling loading on a veloergometer up to an oxygen uptake of 1.5 1/min--1, considerably higher oxygen uptake was established in the obese as comparable loading grades and in some of the cases--hypeptensive reaction was found.	Oxygen	65-71	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
676298-2	1978	With the progressive cycling loading on a veloergometer up to an oxygen uptake of 1.5 1/min--1, considerably higher oxygen uptake was established in the obese as comparable loading grades and in some of the cases--hypeptensive reaction was found.	Oxygen	116-122	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
620497-4	1978	In hyperphosphataemia whole-blood affinity for oxygen was slightly decreased, as measured by an increase in P50 (the partial pressure of oxygen necessary to half saturate haemoglobin).	Oxygen	47-53	nuclear factor kappa B subunit 1	Homo sapiens	108-111
620497-4	1978	In hyperphosphataemia whole-blood affinity for oxygen was slightly decreased, as measured by an increase in P50 (the partial pressure of oxygen necessary to half saturate haemoglobin).	Oxygen	137-143	nuclear factor kappa B subunit 1	Homo sapiens	108-111
606304-4	1977	Haemoglobin concentration and P50 value would represent an adaptative mechanism to hypoxia: when hypoxia is moderate (80 greater than PaO2 greater than or equal to 65 torr) and isolated, oxygen haemoglobin affinity decreases (P50 increases); when hypoxia is severe (PaO2 less than 65 torr) and combined with hypercapnia and disturbed acid-base equilibrium, P50 comes back to normal range but haemoglobin increases, restoring thus, the normal blood oxygen content.	Oxygen	187-193	nuclear factor kappa B subunit 1	Homo sapiens	226-229
606304-4	1977	Haemoglobin concentration and P50 value would represent an adaptative mechanism to hypoxia: when hypoxia is moderate (80 greater than PaO2 greater than or equal to 65 torr) and isolated, oxygen haemoglobin affinity decreases (P50 increases); when hypoxia is severe (PaO2 less than 65 torr) and combined with hypercapnia and disturbed acid-base equilibrium, P50 comes back to normal range but haemoglobin increases, restoring thus, the normal blood oxygen content.	Oxygen	187-193	nuclear factor kappa B subunit 1	Homo sapiens	226-229
202259-0	1977	Relationship between the reduction of oxygen, artificial acceptors and cytochrome P-450 by NADPH--cytochrome c reductase.	Oxygen	38-44	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-87
202259-0	1977	Relationship between the reduction of oxygen, artificial acceptors and cytochrome P-450 by NADPH--cytochrome c reductase.	Oxygen	38-44	cytochrome c, somatic	Homo sapiens	98-110
202259-1	1977	The interaction of NADPH--cytochrome c reductase with oxygen, artificial acceptors and cytochrome P-450 was studied.	Oxygen	54-60	cytochrome c, somatic	Homo sapiens	26-38
907369-4	1977	The inhibition of the enzymatic reaction by metyrapone, naphthoflavone, tetrahydrofurane or CO/O2 presents neither the typical pattern of the phenobarbital type nor the typical pattern of the benzpyrene type of cytochrome P-450.	Oxygen	95-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	211-227
200145-2	1977	The results show that as the extracellular oxygen concentration falls there is a decrease in the respiratory rate, which is accompanied by a decrease in the [ATP]/[ADP] and a progressive reduction of cytochrome c.	Oxygen	43-49	cytochrome c, somatic	Homo sapiens	200-212
200145-3	1977	Even at low O2 tensions the mitochondrial respiratory chain between the NAD couple and cytochrome c remains at near equilibrium with the ATP synthesizing reactions.	Oxygen	12-14	cytochrome c, somatic	Homo sapiens	87-99
16660162-5	1977	In contrast, the half-maximal inhibition of O(2) uptake rate was obtained at greater KCN concentration in the normal cells (20 muM) compared to copper-deficient cells (2 muM).	Oxygen	44-48	latexin	Homo sapiens	127-130
16660162-5	1977	In contrast, the half-maximal inhibition of O(2) uptake rate was obtained at greater KCN concentration in the normal cells (20 muM) compared to copper-deficient cells (2 muM).	Oxygen	44-48	latexin	Homo sapiens	170-173
18962166-1	1977	In neutral unbuffered solutions containing dissolved oxygen, the normal pulse polarograms of certain metal ions [Pb(II), Cd(II), Zn(II), Co(II) and Mn(II)] produce peaks on the limiting plateaux.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
199281-3	1977	The physiological role of SOD is discussed in relation to the stability of cells photosynthesizing organisms towards light and oxygen effect.	Oxygen	127-133	superoxide dismutase 1	Homo sapiens	26-29
200145-4	1977	It is concluded that limited oxygen supply affects cellular metabolism at much higher concentrations than the P50 value for the oxygen dependence of respiration, but the respiratory rate remains relatively unchanged due to compensatory changes in the [ATP]/[ADP] X [Pi] and progressive reduction of cytochrome c.	Oxygen	29-35	cytochrome c, somatic	Homo sapiens	299-311
916622-0	1977	Oxygen-induced synthesis of superoxide dismutase and catalase in pulmonary macrophages of neonatal rats.	Oxygen	0-6	catalase	Rattus norvegicus	53-61
270668-3	1977	A23187 also induces an antimycin A-insensitive burst in oxygen utilization which is partially blocked by 5 mM aspirin or 10 muM indomethacin.	Oxygen	56-62	latexin	Homo sapiens	124-127
20529-6	1977	The elevated PAp was always significantly reduced by oxygen therapy or IPPB or the combination of both.	Oxygen	53-59	PDGFA associated protein 1	Homo sapiens	13-16
26174-2	1977	The hemoglobin-oxygen affininty was markedly increased with P50 varying from 22.3 to 17.7 mmHg.	Oxygen	15-21	nuclear factor kappa B subunit 1	Homo sapiens	60-63
613772-0	1977	Myoglobin-O2-saturation profiles in muscle sections of chicken gizzard and the facilitated O2-transport by Mb+.	Oxygen	10-12	myoglobin	Gallus gallus	0-9
198771-0	1977	Oxygen "pulsed" cytochrome c oxidase: functional properties and catalytic relevance.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	16-28
198771-1	1977	The kinetics of the reaction of cytochrome c with solubilized mammalian cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) has been studied by a stopped-flow technique under two different experimental situations: (i) the completely oxidized enzyme (resting oxidase as obtained from the preparation) was mixed with reduced cytochrome c, and (ii) the completely reduced enzyme in the presence of reduced cytochrome c was exposed to a "pulse" of O2 (pulsed oxidase).	Oxygen	467-469	cytochrome c, somatic	Homo sapiens	32-44
198771-1	1977	The kinetics of the reaction of cytochrome c with solubilized mammalian cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) has been studied by a stopped-flow technique under two different experimental situations: (i) the completely oxidized enzyme (resting oxidase as obtained from the preparation) was mixed with reduced cytochrome c, and (ii) the completely reduced enzyme in the presence of reduced cytochrome c was exposed to a "pulse" of O2 (pulsed oxidase).	Oxygen	467-469	cytochrome c, somatic	Homo sapiens	72-84
198771-1	1977	The kinetics of the reaction of cytochrome c with solubilized mammalian cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) has been studied by a stopped-flow technique under two different experimental situations: (i) the completely oxidized enzyme (resting oxidase as obtained from the preparation) was mixed with reduced cytochrome c, and (ii) the completely reduced enzyme in the presence of reduced cytochrome c was exposed to a "pulse" of O2 (pulsed oxidase).	Oxygen	467-469	cytochrome c, somatic	Homo sapiens	72-84
198771-1	1977	The kinetics of the reaction of cytochrome c with solubilized mammalian cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) has been studied by a stopped-flow technique under two different experimental situations: (i) the completely oxidized enzyme (resting oxidase as obtained from the preparation) was mixed with reduced cytochrome c, and (ii) the completely reduced enzyme in the presence of reduced cytochrome c was exposed to a "pulse" of O2 (pulsed oxidase).	Oxygen	467-469	cytochrome c, somatic	Homo sapiens	72-84
198028-1	1977	The interaction of NADPH-cytochrome c reductase with oxygen, artificial acceptors and cytochrome P-450 is investigated.	Oxygen	53-59	cytochrome c, somatic	Homo sapiens	25-37
879018-2	1977	In vitro, and in normal man propranolol shifts the oxyhemoglobin equilibrium curve to the right, thus increasing the partial pressure of oxygen at which hemoglobin is 50% saturated (P50) and enhancing oxygen delivery.	Oxygen	137-143	nuclear factor kappa B subunit 1	Homo sapiens	182-185
879336-4	1977	During vasopressin infusion, the heterogeneity of oxygen saturation and xenon activity in the portal branches increased significantly.	Oxygen	50-56	arginine vasopressin	Homo sapiens	7-18
198028-2	1977	It is found that generation of oxygen anion-radicals (O2-), determined from the reaction of adrenaline oxidation into adrenochrome, proceeds independently on the reactions of interaction with artificial "anaerobic" acceptors-cytochrome c, dichlorophenolindophenol.	Oxygen	54-57	cytochrome c, somatic	Homo sapiens	225-237
198028-6	1977	On the basis of the data obtained it is suggested that the reactions of NADPH-cytochrome c reductase interaction with oxygen and artificial "anaerobic" acceptors are connected with different redox-states of flavoprotein or with different flavine coenzymes, and that the electron transport on cytochrome P-450 and directly on oxygen takes place in interrelated redox-states of flavoprotein.	Oxygen	118-124	cytochrome c, somatic	Homo sapiens	78-90
198028-6	1977	On the basis of the data obtained it is suggested that the reactions of NADPH-cytochrome c reductase interaction with oxygen and artificial "anaerobic" acceptors are connected with different redox-states of flavoprotein or with different flavine coenzymes, and that the electron transport on cytochrome P-450 and directly on oxygen takes place in interrelated redox-states of flavoprotein.	Oxygen	118-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	292-308
198028-6	1977	On the basis of the data obtained it is suggested that the reactions of NADPH-cytochrome c reductase interaction with oxygen and artificial "anaerobic" acceptors are connected with different redox-states of flavoprotein or with different flavine coenzymes, and that the electron transport on cytochrome P-450 and directly on oxygen takes place in interrelated redox-states of flavoprotein.	Oxygen	325-331	cytochrome c, somatic	Homo sapiens	78-90
198028-6	1977	On the basis of the data obtained it is suggested that the reactions of NADPH-cytochrome c reductase interaction with oxygen and artificial "anaerobic" acceptors are connected with different redox-states of flavoprotein or with different flavine coenzymes, and that the electron transport on cytochrome P-450 and directly on oxygen takes place in interrelated redox-states of flavoprotein.	Oxygen	325-331	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	292-308
902650-8	1977	Oxygen uptake (ml - kg-1) and heart rate (beats - min-1) increase more in running than in walking, actual steprate (steps - min-1) however increases less in running compared to walking.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
407362-1	1977	Toad bladder epithelial cells were isolated under mild conditions in a calcium-free medium; they were found to exclude trypan blue, to consume oxygen, and to respond to vasopressin with an increased rate of oxygen consumption.	Oxygen	207-213	arginine vasopressin	Homo sapiens	169-180
16010-3	1977	Similar measurements were done on Hb A and the fraction of oxygen-linked carbamate calculated from the effect of pCO2 (at constant pH) on the oxygen half-saturation pressure (p50).	Oxygen	59-65	nuclear factor kappa B subunit 1	Homo sapiens	175-178
16352-1	1977	The purpose of this study was to examine the magnitude of the influence of coronary arterial pH (pHa) on myocardial oxygen uptake (MV 02).	Oxygen	116-122	lamin B receptor	Homo sapiens	97-100
889078-0	1977	Catalase activity measured with a micro oxygen electrode in a pressurized reaction vessel.	Oxygen	40-46	catalase	Homo sapiens	0-8
889081-0	1977	A more sensitive modification of the catalase assay with the Clark oxygen electrode.	Oxygen	67-73	catalase	Homo sapiens	37-45
559282-0	1977	Neonatal red cell superoxide dismutase enzyme levels: possible role as a cellular defense mechanism against pulmonary oxygen toxicity.	Oxygen	118-124	superoxide dismutase 1	Homo sapiens	18-38
559282-7	1977	When infants with RDS were examined for oxygen toxicity and survival, red cell SOD levels were noted to decrease over 24 hr in four of five infants who died, three of whom developed bronchopulmonary dysplasia.	Oxygen	40-46	superoxide dismutase 1	Homo sapiens	79-82
861242-4	1977	Mass spectral analysis of the persilylated glycol products III and IV showed no uptake of 18O, indicating that the oxygen atoms of the C20-, C22- and C21-hydroxyl groups originated from the 20-hydroperoxy atomic oxygen complex is the intermediate in the enzymic oxidative reactions of cholesterol side-chain cleavage.	Oxygen	115-121	TBL1X/Y related 1	Homo sapiens	150-153
16010-3	1977	Similar measurements were done on Hb A and the fraction of oxygen-linked carbamate calculated from the effect of pCO2 (at constant pH) on the oxygen half-saturation pressure (p50).	Oxygen	142-148	nuclear factor kappa B subunit 1	Homo sapiens	175-178
849931-7	1977	The range of p50 (oxygen pressure at half-saturation) values for four normal subjects was 28.3 mm Hg to 29.0 mm Hg.	Oxygen	18-24	nuclear factor kappa B subunit 1	Homo sapiens	13-16
844210-0	1977	The effect of 2,3-diphosphoglycerate on oxygen consumption burst in thrombin-stimulated platelets.	Oxygen	40-46	coagulation factor II, thrombin	Homo sapiens	68-76
326669-3	1977	There was a correlation between the enzyme level and the oxygen tolerance, in that the aerotolerant and intermediate organisms had SOD, whereas the extremely oxygen-sensitive isolates had low or undetectable enzyme.	Oxygen	57-63	superoxide dismutase 1	Homo sapiens	131-134
326669-4	1977	Among the oxygen-tolerant organisms, gram-negative bacteria had higher levels of SOD than gram-positive organisms.	Oxygen	10-16	superoxide dismutase 1	Homo sapiens	81-84
326669-5	1977	Oxygen was shown to induce SOD production in a strain of Bacteriodes fragilis grown in minimal medium under continuous-culture conditions.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	27-30
326669-7	1977	Our data suggest that the variation in oxygen tolerance of anaerobes is usually related to their level of SOD.	Oxygen	39-45	superoxide dismutase 1	Homo sapiens	106-109
852592-0	1977	Sub-zero temperature studies of microsomal cytochrome P-450: interaction of Fe2+ with oxygen.	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
857856-3	1977	Theoretically, haem--haem interaction values in the range that has been reported for apparently healthy human subjects can substantially modify oxygen transport to tissues, in some cases equalling or exceeding the effect from a similar range of P50 values.	Oxygen	144-150	nuclear factor kappa B subunit 1	Homo sapiens	245-248
16507-7	1977	These results indicate that the biotransformation of methoxyflurane is preceded by interaction with cytochrome p-450 in hepatic microsomes in the presence of NADPH and oxygen.	Oxygen	168-174	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-116
844210-4	1977	It was observed that 2,3-DPG diminishes oxygen consumption induced by thrombin.	Oxygen	40-46	coagulation factor II, thrombin	Homo sapiens	70-78
831500-3	1977	The release of decidual prolactin was affected by the presence or absence of oxygen and protein, and the amount of prolactin released far exceeded the decrease in tissue content during incubation.	Oxygen	77-83	prolactin	Homo sapiens	24-33
836868-4	1977	The present results indicate that oxygen equilibrium properties are only slightly influenced bysubunit dissociation in the concentration range above 60 muM (as heme) at which most equilibrium experiments have been carried out.	Oxygen	34-40	latexin	Homo sapiens	152-155
850271-2	1977	The release of oxygen to the tissues is regulated directly through the venous oxygen tension and indirectly through cardiac output, the 2,3-DPG system, and erythropoietin.	Oxygen	15-21	erythropoietin	Homo sapiens	156-170
23525-4	1977	After dialysis Hb-O2 affinity at the patient"s pH (p50 in vivo = 27.97 +/- 0.57 mmHg, P less than 0.001).	Oxygen	18-20	nuclear factor kappa B subunit 1	Homo sapiens	51-54
19937-5	1977	The fact that the function of cytochrome P-450 is sensitive to changes in oxygen tension establishes its role as an "oxygen sensor" for cellular metabolism.	Oxygen	74-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46
19937-5	1977	The fact that the function of cytochrome P-450 is sensitive to changes in oxygen tension establishes its role as an "oxygen sensor" for cellular metabolism.	Oxygen	117-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46
597176-0	1977	Oxygen diffusion facilitated by myoglobin in the chicken gizzard smooth muscle.	Oxygen	0-6	myoglobin	Gallus gallus	32-41
835887-4	1977	I demonstrate that in hypoxemic patients, especially if anemia and shock are present, the arterial Po2 may be less than the crossover Po2; thus, an increased blood P50, the Po2 at oxygen saturation of 50 per cent (pH 7.40, temperature 37 degrees C), cannot increase the mixed venous Po2.	Oxygen	180-186	nuclear factor kappa B subunit 1	Homo sapiens	164-167
13994-1	1977	Irradiation with visible light of human serum albumin in aqueous solution at pH 8, in the presence of catalytic amounts of rose bengal or methylene blue, resulted in random oxidation of the histidine residues in the protein under consumption of one mole O2, and release of somewhat less than one proton, per histidine residue degraded.	Oxygen	254-256	albumin	Homo sapiens	46-53
13994-6	1977	Irradiation of a complex of human serum albumin with one molecule of bound bilirubin, in the absence of a sensitizing dye, resulted in a fast, non-oxygen consuming process whereby the light absorption maximum of the pigment was shifted 4 nm towards longer wavelength and part of the bilirubin was converted to a more polar pigment, bound less firmly to the protein.	Oxygen	147-153	albumin	Homo sapiens	40-47
916372-1	1977	Severinghaus" equation can safely be used for the indirect estimation of oxygen half saturation pressure (P50) on the basis of blood gas parameters in normal subjects.	Oxygen	73-79	nuclear factor kappa B subunit 1	Homo sapiens	106-109
193132-4	1977	Some of the systems that depend on oxygen also require myeloperoxidase.	Oxygen	35-41	myeloperoxidase	Homo sapiens	55-70
13495-1	1977	The therapeutic effect of beta adrenoceptor blockers in angina pectoris can be ascribed to an inhibition of beta1 receptor mediated stimulation of heart rate and myocardial contractility, resulting in an improved oxygen supply-demand balance in the myocardium.	Oxygen	213-219	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	108-113
824157-2	1976	Cytochrome P-450 serves as the binding site for oxygen and substrate while the reductase acts as an electron carrier shuttling electrons from NADPH to cytochrome P-450.	Oxygen	48-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
11817-0	1976	Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration.	Oxygen	140-146	ferrochelatase	Rattus norvegicus	15-29
12111-4	1976	A peptide chloromethyl ketone elastase inhibitor abolished both elastolytic activity and the pctentiating effects on MPO-H2-O2-mediated bacterial killing.	Oxygen	124-126	myeloperoxidase	Homo sapiens	117-120
602510-8	1977	The reaction of another important pharmacological substance bradykinin (BRS), has been closely associated with oxygen saturation of the perfusion solution.	Oxygen	111-117	kininogen 1	Homo sapiens	60-70
992231-6	1976	This decrease in the level of Hb AIc in diabetics who are pregnant more than 30 weeks may reflect either a better state of diabetic control and/or a compensatory mechanism to protect the fetus by facilitating oxygen exchange from mother to fetus.	Oxygen	209-215	AIC	Homo sapiens	33-36
186125-0	1976	The effect of oxygen concentration on the steady-state kinetics of the solubilized cytochrome c oxidase.	Oxygen	14-20	cytochrome c, somatic	Homo sapiens	83-95
186125-2	1976	The steady-state kinetics of ascorbate oxidation as a function of oxygen concentration was measured with a solubilized cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) preparation.	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	119-131
186125-10	1976	The Km for oxygen at infinite cytochrome c concentration is 0.95 muM and the intramolecular rate constant for the transfer of electrons from cytochrome c to cytochome aa3 is 400 s(-1).	Oxygen	11-17	cytochrome c, somatic	Homo sapiens	30-42
186125-10	1976	The Km for oxygen at infinite cytochrome c concentration is 0.95 muM and the intramolecular rate constant for the transfer of electrons from cytochrome c to cytochome aa3 is 400 s(-1).	Oxygen	11-17	cytochrome c, somatic	Homo sapiens	141-153
824157-2	1976	Cytochrome P-450 serves as the binding site for oxygen and substrate while the reductase acts as an electron carrier shuttling electrons from NADPH to cytochrome P-450.	Oxygen	48-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	151-167
184842-5	1976	In the presence of formate after depletion of O2, there is an unusual two-step time course of reduction of the membrane-bound cytochrome c.	Oxygen	46-48	cytochrome c, somatic	Homo sapiens	126-138
12746-10	1976	In the mechanism of action of carbonyl cyanide m-chlorophenylhydrazone the key step may be the electrostatic interaction of its protonated form and one of the forms of activated oxygen at the catalytic centre of cytochrome P-450.	Oxygen	178-184	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	212-228
184842-7	1976	We conclude that the observed two-stage reduction of cytochrome c results from the presence of an oxidant, probably H2O2, produced by reaction of formate dehydrogenase with O2.	Oxygen	118-120	cytochrome c, somatic	Homo sapiens	53-65
8233-4	1976	P50 (oxygen tension at 50% oxygen saturation) expressed at plasma pH 7-40 and PCO2 5-33 kPa showed a positive correlation with age.	Oxygen	5-11	nuclear factor kappa B subunit 1	Homo sapiens	0-3
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Oxygen	122-124	cytochrome c, somatic	Homo sapiens	203-215
9138-5	1976	Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.	Oxygen	126-128	cytochrome c, somatic	Homo sapiens	203-215
969022-3	1976	Maximal oxygen uptake (VO2 max) during HOI was 3.18 liters - min-1, which was not statistically different from the mean of 3.29 liters- min-1 in air.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
8233-4	1976	P50 (oxygen tension at 50% oxygen saturation) expressed at plasma pH 7-40 and PCO2 5-33 kPa showed a positive correlation with age.	Oxygen	27-33	nuclear factor kappa B subunit 1	Homo sapiens	0-3
962470-4	1976	Since it has been shown by others that lightdriven ATP synthesis can occur under anaerobic conditions, it is postulated that rhodopsin-mediated photophosphorylation is of survival value for this organism in the brines in which it lives, especially because the solubility of oxygen is low in highly saline waters and anaerobic conditions can often develop.	Oxygen	274-280	rhodopsin	Homo sapiens	125-134
989975-0	1976	Oxygen consumption in platelets of newborn infants before and after stimulation by thrombin.	Oxygen	0-6	coagulation factor II, thrombin	Homo sapiens	83-91
989975-3	1976	The burst in oxygen consumption after thrombin addition was 26.30 mumol/10(9)/min in adults and 24.90 in infants.	Oxygen	13-19	coagulation factor II, thrombin	Homo sapiens	38-46
986609-3	1976	The oxygen uptake increased from 0.261 - min-1 at rest to about 1.61-min-1 during work.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	41-46
6461-8	1976	Oxygen was essential for protoporphyrinogen oxidase activity and an alternative elevtron acceptor has not yet been found.	Oxygen	0-6	protoporphyrinogen oxidase	Homo sapiens	25-51
986609-3	1976	The oxygen uptake increased from 0.261 - min-1 at rest to about 1.61-min-1 during work.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	69-74
5935-4	1976	An equation can be used to convert the venous oxygen tension (standardized to pH 7.4) and the oxygen saturation to the P50 of the oxygen-hemoglobin dissociation curve on which the observed point falls.	Oxygen	46-52	nuclear factor kappa B subunit 1	Homo sapiens	119-122
931929-2	1976	Measurements were made with the subjects at rest, exercising at approximately 0.8 liter oxygen-min-1, and very vigorously at 1.8-2.0 liters oxygen-min-1.	Oxygen	88-94	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
931929-2	1976	Measurements were made with the subjects at rest, exercising at approximately 0.8 liter oxygen-min-1, and very vigorously at 1.8-2.0 liters oxygen-min-1.	Oxygen	140-146	CD59 molecule (CD59 blood group)	Homo sapiens	147-152
194788-3	1976	DTPP produced a moderate stimulation of the iron-containing enzymes (catalase, peroxidase, cytochroxidase) which led to an increased oxygen consumption.	Oxygen	133-139	catalase	Rattus norvegicus	69-77
5935-4	1976	An equation can be used to convert the venous oxygen tension (standardized to pH 7.4) and the oxygen saturation to the P50 of the oxygen-hemoglobin dissociation curve on which the observed point falls.	Oxygen	94-100	nuclear factor kappa B subunit 1	Homo sapiens	119-122
5935-4	1976	An equation can be used to convert the venous oxygen tension (standardized to pH 7.4) and the oxygen saturation to the P50 of the oxygen-hemoglobin dissociation curve on which the observed point falls.	Oxygen	94-100	nuclear factor kappa B subunit 1	Homo sapiens	119-122
1262333-0	1976	Mechanism of the thrombin-mediated burst in oxygen consumption by human platelets.	Oxygen	44-50	coagulation factor II, thrombin	Homo sapiens	17-25
1026517-2	1976	Joint administration of insulin and estradiol restored nearly to the initial level the rate of the oxygen consumption and esterification of inorganic phosphorus in the uterus and liver.	Oxygen	99-105	insulin	Homo sapiens	24-31
1262333-3	1976	Further, added aspirin, a known inhibitor of the burst in O2 consumption caused by thrombin, also blunted the stimulatory effect of arachidonate on O2 consumption, and eicosatetraynoate, a known inhibitor of arachidonate oxygenation, blunted the burst in O2 consumption initiated by both thrombin and arachidonate.	Oxygen	58-60	coagulation factor II, thrombin	Homo sapiens	83-91
1262333-3	1976	Further, added aspirin, a known inhibitor of the burst in O2 consumption caused by thrombin, also blunted the stimulatory effect of arachidonate on O2 consumption, and eicosatetraynoate, a known inhibitor of arachidonate oxygenation, blunted the burst in O2 consumption initiated by both thrombin and arachidonate.	Oxygen	148-150	coagulation factor II, thrombin	Homo sapiens	83-91
1262333-3	1976	Further, added aspirin, a known inhibitor of the burst in O2 consumption caused by thrombin, also blunted the stimulatory effect of arachidonate on O2 consumption, and eicosatetraynoate, a known inhibitor of arachidonate oxygenation, blunted the burst in O2 consumption initiated by both thrombin and arachidonate.	Oxygen	148-150	coagulation factor II, thrombin	Homo sapiens	83-91
1262333-4	1976	We conclude that rapid oxygenation of endogenously released arachidonic acid accounts for the thrombin-mediated burst in oxygen consumption by platelets.	Oxygen	23-29	coagulation factor II, thrombin	Homo sapiens	94-102
1030637-1	1976	The common view of photosystem I as the action site of catalase and ethanol at oxygen uptake in chloroplasts  are based on indirect data on this reaction.	Oxygen	79-85	catalase	Homo sapiens	55-63
1030637-3	1976	It has been demonstrated that oxygen uptake with catalase and ethanol does not decrease in presence of dibromothymoquinone (2,5-dibromo-3-methyl-6 isopropyl-p-benzoquinone--DBTQ) which blocks electron transfer to photosystem I at plastoquinones level.	Oxygen	30-36	catalase	Homo sapiens	49-57
1030637-4	1976	The summation of oxygen uptake activities is observed on the combined action of catalase and ethanol with any of the Mehler reagents functioning in photosystem I (methylviologen,FMN, epinephrine, ferredoxin).	Oxygen	17-23	catalase	Homo sapiens	80-88
1030637-6	1976	The quatum yield of oxygen uptake with catalase and ethanol versus wave length of actinic light shows a distinct maximum in the photosystem II absorption area and a "red drop" in the longware area.	Oxygen	20-26	catalase	Homo sapiens	39-47
1262333-2	1976	We also show that added arachidonic acid causes a burst in O2 consumption that mimics one of the well described effects of thrombin on these cells.	Oxygen	59-61	coagulation factor II, thrombin	Homo sapiens	123-131
933486-0	1976	The effect of diminished P50 on intrahepatic oxygen tension as measured in bile.	Oxygen	45-51	nuclear factor kappa B subunit 1	Homo sapiens	25-28
1260021-0	1976	Thrombin-induced oxygen consumption, malonyldialdehyde formation and serotonin secretion in human platelets.	Oxygen	17-23	coagulation factor II, thrombin	Homo sapiens	0-8
1260021-1	1976	The relationship of a thrombin-induced burst in O2 consumption to lipid peroxidation in washed human platelets was investigated by measuring malonyldialdehyde, a by-product of endoperoxide degradation in platelets.	Oxygen	48-50	coagulation factor II, thrombin	Homo sapiens	22-30
1260021-3	1976	Acetylsalicylate blocked the formation of malonyldialdehyde completely and partially inhibited the O2 burst induced by thrombin.	Oxygen	99-101	coagulation factor II, thrombin	Homo sapiens	119-127
1250644-7	1976	Exposure of New Zealand White rabbits, prematurely delivered by caesarian section, to 80% oxygen for 24 hr resulted in a 42% increase in lung SOD activity.	Oxygen	90-96	superoxide dismutase 1	Homo sapiens	142-145
816344-6	1976	Allele frequency shifts to 6-phosphogluconate dehydrogenase and phosphoglucomutase were observed in 5% oxygen, and a shift of alpha-glycerophosphate dehydrogenase allele frequencies occurred in 60% oxygen.	Oxygen	198-204	Glycerol-3-phosphate dehydrogenase 1	Drosophila melanogaster	126-162
1253786-6	1976	), in 2 subjects exercising on a bicycle ergometer, DO2 was found to increase from a resting value of about 32 ml- min-1 - Torr-1 to 107 ml - min-1 - Torr-1 for an eightfold increase of O2 uptake.	Oxygen	53-55	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
1253786-6	1976	), in 2 subjects exercising on a bicycle ergometer, DO2 was found to increase from a resting value of about 32 ml- min-1 - Torr-1 to 107 ml - min-1 - Torr-1 for an eightfold increase of O2 uptake.	Oxygen	53-55	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
931868-1	1976	If carbon monoxide is present in the blood, it is necessary to quantitate its effect on apparent O2 affinity in order to properly compute venous PO2 and P50.	Oxygen	97-99	nuclear factor kappa B subunit 1	Homo sapiens	153-156
1250644-8	1976	Similarly, 7-day-old Sprague-Dawley rats exposed to 85% oxygen for 24 hr showed a 43% increase in pulmonary SOD activity.	Oxygen	56-62	superoxide dismutase 1	Homo sapiens	108-111
1250644-11	1976	Rat lung, incubated in either heparinized whole blood or in plasma and exposed to 100% oxygen, showed a 30% increase in SOD activity after 2 hr.	Oxygen	87-93	superoxide dismutase 1	Homo sapiens	120-123
1250644-14	1976	The oxygen-stimulated increase in lung SOD activity disappeared at about 19-20 days of age.	Oxygen	4-10	superoxide dismutase 1	Homo sapiens	39-42
1248452-2	1976	In puppies with oxygen deficiency, insulin levels declined, whereas during epinephrine infusion, they remained stable or increased slightly.	Oxygen	16-22	insulin	Homo sapiens	35-42
2321-2	1976	Techniques and experiments are described concerned with the millisecond kinetics of EPT-detectable changes brought about in cytochrome c oxidase by reduced cytochrome c and, after reduction with various agents, by reoxidation with O2 or ferricyanide.	Oxygen	231-233	cytochrome c, somatic	Homo sapiens	124-136
2321-11	1976	On reoxidation of reduced enzyme by oxygen all EPR and optical features are restored within 6 ms. On reoxidation by O2 in the presence of an excess of reduced cytochrome c, states can be observed where the low-spin heme and copper signals are largely absent but the absorption at 655 nm is maximal, indicating that the low-spin heme and copper components are at the substrate side and the component(s) represented in the 655 nm absorption at the O2 side of the system.	Oxygen	36-42	cytochrome c, somatic	Homo sapiens	159-171
2321-11	1976	On reoxidation of reduced enzyme by oxygen all EPR and optical features are restored within 6 ms. On reoxidation by O2 in the presence of an excess of reduced cytochrome c, states can be observed where the low-spin heme and copper signals are largely absent but the absorption at 655 nm is maximal, indicating that the low-spin heme and copper components are at the substrate side and the component(s) represented in the 655 nm absorption at the O2 side of the system.	Oxygen	116-118	cytochrome c, somatic	Homo sapiens	159-171
2321-11	1976	On reoxidation of reduced enzyme by oxygen all EPR and optical features are restored within 6 ms. On reoxidation by O2 in the presence of an excess of reduced cytochrome c, states can be observed where the low-spin heme and copper signals are largely absent but the absorption at 655 nm is maximal, indicating that the low-spin heme and copper components are at the substrate side and the component(s) represented in the 655 nm absorption at the O2 side of the system.	Oxygen	446-448	cytochrome c, somatic	Homo sapiens	159-171
4201-12	1976	The inhibition of this cleavage by superoxide dismutase (EC 1.15.1.1) and catalase (EC 1.11.1.6), and by free radical scavengers suggests that the degradation of DNA observed to accompany the cytotoxic action of mitomycin C is largely due to the free radical O2.	Oxygen	259-261	catalase	Homo sapiens	74-82
814406-3	1976	The enzymatic destruction of oxidizing products produced during metabolic reduction of oxygen in the cell (such as singlet oxygen, H2O2 and OH radical) involves the concerted action of superoxide dismutase-which removes O-2 and yields H2O2-and H2O2 removing enzymes such as catalase and glutathione peroxidase.	Oxygen	87-93	catalase	Homo sapiens	274-282
1245483-6	1976	In spite of the very low oxygen affinity of the cross-linked hemoglobin, combination with haptoglobin shifts if oxygen affinity to the very high value of the normal hemoglobin-haptoglobin complex.	Oxygen	112-118	haptoglobin	Homo sapiens	90-101
1245483-6	1976	In spite of the very low oxygen affinity of the cross-linked hemoglobin, combination with haptoglobin shifts if oxygen affinity to the very high value of the normal hemoglobin-haptoglobin complex.	Oxygen	112-118	haptoglobin	Homo sapiens	176-187
3172-4	1975	This reaction was first-order with respect to Fe(III)-phosvitin concentration with a half-time (t1/2) of 10 min, and a first-order rate constant, k=0.069min-1, in 700 muM-phosphate buffer, pH 7.2, at 30 degrees C. The catalysis of the oxidation of Fe(III) by phosvitin was proportional to O2 concentration, and is quite different from the relative O2 independence of Fe(II) oxidation as catalysed by ferroxidase.	Oxygen	289-291	Casein kinase II subunit beta	Gallus gallus	54-63
935837-2	1976	Oxygen consumption of  normal subjects when walking at velocities of 0.5, 1.0 and 1.5 m sec-1 was 8.0, 9.8 and 13.6 ml kg-1 min-1 respectively.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
935837-3	1976	For subjects walking on crutches with the leg encased in a Plaster of Paris cast, the oxygen consumption at these velocities was 12.0, 17.5 and 25.3 ml kg-1 min-1 respectively.	Oxygen	86-92	CD59 molecule (CD59 blood group)	Homo sapiens	157-162
179806-3	1976	At 37 degrees C, and in the presence of hexokinase and glucose, the oxygen uptake was greater than at 25 degrees C and in their absence.	Oxygen	68-74	hexokinase 1	Homo sapiens	40-50
5828-3	1976	The kinetics of the photodynamic desactivation of lysozyme in presence of acridine orange as the sensitizer have been investigated in detail varying oxygen, protein, dye concentration, ionic strength and pH value.	Oxygen	149-155	lysozyme	Homo sapiens	50-58
88-0	1975	The oxygen affinity of haemoglobin Tak, a variant with an elongated beta chain.	Oxygen	4-10	cyclin dependent kinase 9	Homo sapiens	35-38
88-1	1975	The oxygen affinity was investigated of purified Hb Tak, a human haemoglobin variant with elongated beta-chains.	Oxygen	4-10	cyclin dependent kinase 9	Homo sapiens	52-55
88-4	1975	The oxygen equilibrium curve of the whole blood haemolysate containing Hbs A and Tak was close to that of Hb A at the top of the curve, while the bottom of the curve greatly deviated from the latter, indicative of small if any interaction between Hb A and Tak during oxygenation.	Oxygen	4-10	cyclin dependent kinase 9	Homo sapiens	81-84
88-4	1975	The oxygen equilibrium curve of the whole blood haemolysate containing Hbs A and Tak was close to that of Hb A at the top of the curve, while the bottom of the curve greatly deviated from the latter, indicative of small if any interaction between Hb A and Tak during oxygenation.	Oxygen	4-10	cyclin dependent kinase 9	Homo sapiens	256-259
3172-4	1975	This reaction was first-order with respect to Fe(III)-phosvitin concentration with a half-time (t1/2) of 10 min, and a first-order rate constant, k=0.069min-1, in 700 muM-phosphate buffer, pH 7.2, at 30 degrees C. The catalysis of the oxidation of Fe(III) by phosvitin was proportional to O2 concentration, and is quite different from the relative O2 independence of Fe(II) oxidation as catalysed by ferroxidase.	Oxygen	348-350	Casein kinase II subunit beta	Gallus gallus	54-63
172888-6	1975	O2 was required for demonstration of the Ca++-dependent accumulation of cGMP in response to bradykinin, histamine, and ionophore A23187.	Oxygen	0-2	kininogen 1	Homo sapiens	92-102
1202557-7	1975	For small oxygen concentrations of 0.15 to 0.5 muM/l and doses below 1000 R Revesz and Littbrand have found that oxygen can protect the irradiated cells and thus increase survivals with about 10%.	Oxygen	113-119	latexin	Homo sapiens	47-50
1159264-6	1975	By extrapolation of these heart-rate determinations to "maximal heart rate," the maximal oxygen uptake was estimated and expressed as L times min-1 and as ml x min-1 and as ml times kg-1 x min-1.	Oxygen	89-95	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
1159264-6	1975	By extrapolation of these heart-rate determinations to "maximal heart rate," the maximal oxygen uptake was estimated and expressed as L times min-1 and as ml x min-1 and as ml times kg-1 x min-1.	Oxygen	89-95	CD59 molecule (CD59 blood group)	Homo sapiens	160-165
1159264-6	1975	By extrapolation of these heart-rate determinations to "maximal heart rate," the maximal oxygen uptake was estimated and expressed as L times min-1 and as ml x min-1 and as ml times kg-1 x min-1.	Oxygen	89-95	CD59 molecule (CD59 blood group)	Homo sapiens	160-165
776667-0	1975	Biosynthesis of catalase T during oxygen adaptation of Saccharomyces cerevisiae.	Oxygen	34-40	catalase T	Saccharomyces cerevisiae S288C	16-26
241510-2	1975	The method consists of gradually oxygenating a blood sample by adding H2O2 in the presence of catalase (EC 1.11.1.6), to produce the reaction H2O2 leads to H2O + 1/2 O2.	Oxygen	72-74	catalase	Homo sapiens	94-102
175244-5	1975	During oxidation of succinate (citrate, malate or alpha-ketoglutarate) by the cells with ER close to zero, reduction of cytochrome c takes place only some time after the beginning of oxygen uptake.	Oxygen	183-189	cytochrome c, somatic	Homo sapiens	120-132
240014-2	1975	The infants who were treated with CNP before their PaO2 was less than 50 mm Hg while breathing 70% oxygen experienced a significantly greater increase in PaO2 in response to the initiation of CNP, required less time with O2 therapy, required no mechanical ventilation, and had fewer complications.	Oxygen	99-105	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	34-37
240014-2	1975	The infants who were treated with CNP before their PaO2 was less than 50 mm Hg while breathing 70% oxygen experienced a significantly greater increase in PaO2 in response to the initiation of CNP, required less time with O2 therapy, required no mechanical ventilation, and had fewer complications.	Oxygen	99-105	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	192-195
240014-2	1975	The infants who were treated with CNP before their PaO2 was less than 50 mm Hg while breathing 70% oxygen experienced a significantly greater increase in PaO2 in response to the initiation of CNP, required less time with O2 therapy, required no mechanical ventilation, and had fewer complications.	Oxygen	53-55	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	34-37
240014-3	1975	Based on these results, it is suggested that CNP be initiated in infants with HMD, who are less than 24 hours of age and are breathing spontaneously, before the PaO2 becomes less than 50 mm Hg on 70% O2.	Oxygen	163-165	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	45-48
170959-4	1975	MNMT-cytochrome c was found to be, structurally and conformationally, a single isomer, reducible with ascorbate, with a small, but definite affinity for both oxidation with molecular oxygen and binding of CO. Conformationally, in both valence states of the metal atom, it represents a molecular form with native-like conformation with small but definite perturbations in the immediate vicinity of the heme group, reflected by the destabilization of the Met-80-S-Fe linkage.	Oxygen	183-189	cytochrome c, somatic	Homo sapiens	5-17
172888-7	1975	The effect of the phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine on basal cGMP content and on the bradykinin-induced accumulation was also dependent on the presence of O2.	Oxygen	178-180	kininogen 1	Homo sapiens	108-118
1239931-0	1975	[The minimum oxygen volume necessary for maintaining ERG of the living extracorporeal bovine eye (author"s transl)].	Oxygen	13-19	ETS transcription factor ERG	Bos taurus	53-56
169293-2	1975	This was accomplished by allowing them to phagocytize latex particles coated with superoxide dismutase (SOD), which catalyzes the generation of H2O2 from O2.	Oxygen	146-148	superoxide dismutase 1	Homo sapiens	82-102
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	123-125	superoxide dismutase 1	Homo sapiens	0-20
169293-2	1975	This was accomplished by allowing them to phagocytize latex particles coated with superoxide dismutase (SOD), which catalyzes the generation of H2O2 from O2.	Oxygen	146-148	superoxide dismutase 1	Homo sapiens	104-107
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	123-125	superoxide dismutase 1	Homo sapiens	22-25
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	131-137	superoxide dismutase 1	Homo sapiens	0-20
1160997-0	1975	Early role during chemical evolution for cytochrome P450 in oxygen detoxification.	Oxygen	60-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-56
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	131-137	superoxide dismutase 1	Homo sapiens	22-25
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	192-198	superoxide dismutase 1	Homo sapiens	0-20
1228339-1	1975	Superoxide dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity.	Oxygen	192-198	superoxide dismutase 1	Homo sapiens	22-25
1228339-2	1975	In human erythrocytes, O2- arises from autoxidation of oxyhemoglobin and SOD activity is copper-dependent.	Oxygen	23-25	superoxide dismutase 1	Homo sapiens	73-76
1228339-7	1975	SOD may yet decline in other longer-lived tissues or, as suggested by Fridovich, a constant low level of damage may be caused by imperfect scavenging of O2- by SOD.	Oxygen	153-155	superoxide dismutase 1	Homo sapiens	160-163
1155335-0	1975	Oxygen delivery, anoxic metabolism and hemoglobin-oxygen affinity (P50) in patients with acute myocardial infarction and shock.	Oxygen	50-56	nuclear factor kappa B subunit 1	Homo sapiens	67-70
1155335-9	1975	These data indicate that a reduction in oxygen delivery after acute myocardial infarction is followed by a compensatory increase in P50.	Oxygen	40-46	nuclear factor kappa B subunit 1	Homo sapiens	132-135
1155335-10	1975	This change in P50 accounts for increases in oxygen availability independently of changes in cardiac output.	Oxygen	45-51	nuclear factor kappa B subunit 1	Homo sapiens	15-18
1155335-6	1975	In six patients with shock, P50 increased by an average of 4.6 plus or minus 2.05 torr (P less than 0.05) and this augmentation accounted for an estimated 18 percent increase in oxygen release.	Oxygen	178-184	nuclear factor kappa B subunit 1	Homo sapiens	28-31
1179325-5	1975	The cardiac frequencies at oxygen uptake of 0-75 and 1-01 min-1 were significantly higher in the patient groups than in the normal men, and were highest in patient group S. The cardiac output when related to the oxygen uptake was in the normal range in all three groups of subjects, so that the patients had smaller stroke volumes than the normal men.	Oxygen	27-33	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
1163670-4	1975	At 37 degrees C, the value of bladder tissue O2 consumption was 4.4 times 10(-3) min-1 and the value of the Krogh constant for O2 was 2.22 times 10(-5)cm2min-1atm-1.	Oxygen	45-47	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
1179325-6	1975	Ventilation at oxygen uptakes of 0-75 and 1-01 min-1 was significantly higher in both patient groups than in the normal subjects; there were no significant differences between the two patient groups, Values for dead space/tidal volume ration, alveolar-arterial oxygen gradient, and the percent venous admixture measured during a constant work rate test were significantly greater than normal in the patient groups.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	47-52
1216968-0	1975	Proceedings: The effects of adducts and the nature of activated oxygen for cytochrome P-450 catalyzed hydroxylation reactions.	Oxygen	64-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-91
1132410-7	1975	In these conditions the changes in the values of P50 in vivo play an important role in the oxygen delivery to the tissues.	Oxygen	91-97	nuclear factor kappa B subunit 1	Homo sapiens	49-52
1150657-3	1975	The oxygen affinities (P50) of spirographis and 2,4-diformylmyoglobins are 2.7 and 2.8 mm Hg, respectively, at 25 degrees, and about 2.5 times lower than that of native protomyglobin, while that of isospirographis myoglobin is 1.0 mm Hg and is similar to native myoglobin.	Oxygen	4-10	myoglobin	Equus caballus	60-69
1150657-3	1975	The oxygen affinities (P50) of spirographis and 2,4-diformylmyoglobins are 2.7 and 2.8 mm Hg, respectively, at 25 degrees, and about 2.5 times lower than that of native protomyglobin, while that of isospirographis myoglobin is 1.0 mm Hg and is similar to native myoglobin.	Oxygen	4-10	myoglobin	Equus caballus	214-223
1150657-0	1975	Decrease in oxygen affinity of myoglobin by formylation of vinyl groups of heme.	Oxygen	12-18	myoglobin	Equus caballus	31-40
1125335-1	1975	Functional ethanolamine ammonia-lyase is inactivated by N2O as well as by O2, indicating that the active form of coenzyme B12 is an enzyme-bound corrin derivative in which the Co-C bond of the coenzyme is broken and the cobalt ion is in the +1 state of oxidation.	Oxygen	74-76	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	122-125
1162166-5	1975	The O2 uptake of the snail intestine was not significantly affected by the presence of either sugars or phlorizin.	Oxygen	4-6	snail family transcriptional repressor 1	Homo sapiens	21-26
239226-6	1975	When mild maternal hypercapnia was superimposed on maternal hyperoxaemia (oxygen plus 6% carbon dioxide), the oxygen tension and saturation of both the maternal uterine venous and foetal umbilical venous bloods were found when severe hypercapnia was induced (oxygen plus 50% carbon dioxide) but in this case all blood samples showed dramatic changes in PCO2 and pH.	Oxygen	110-116	PCO2	Sus scrofa	353-357
239226-6	1975	When mild maternal hypercapnia was superimposed on maternal hyperoxaemia (oxygen plus 6% carbon dioxide), the oxygen tension and saturation of both the maternal uterine venous and foetal umbilical venous bloods were found when severe hypercapnia was induced (oxygen plus 50% carbon dioxide) but in this case all blood samples showed dramatic changes in PCO2 and pH.	Oxygen	110-116	PCO2	Sus scrofa	353-357
235958-13	1975	The overall oxygen dissociation reaction is biphasic for Ala and Alb, with the two phases differing by a factor of 5; the dissociation reactions for the other three hemoglobins appear essentially monophasic.	Oxygen	12-18	albumin	Homo sapiens	65-68
1191766-1	1975	Three to five hours after 5-hour exposure of rabbits to high oxygen pressure (2 ata) the erythropoietin proved to disappear from both the arterial and the venous blood plasma of the kidneys.	Oxygen	61-67	erythropoietin	Oryctolagus cuniculus	89-103
1080305-3	1975	Insulin stimulated the endogemous respiration from 27 to 38 mm-3 O2/hr.	Oxygen	65-67	insulin	Homo sapiens	0-7
1902-2	1975	In oxidation of NADP.H2 there were at least three point of molecular O2 reduction: NADP.H2-specific flavoprotein, Fe2+ participating in reactions of peroxidation of unsaturated fatty acids and cytochrome P-450.	Oxygen	69-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	193-209
1902-3	1975	Efficiency of cytochrome P-450 inhibitors could not be evaluated by polarography as in the pathway several sites of molecular O2 activation were observed.	Oxygen	126-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
168879-0	1975	Kinetic studies on the reaction between cytochrome c oxidase and ferrocytochrome c. In stopped-flow experiments in which oxidized cytochrome c oxidase was mixed with ferrocytochrome c in the presence of a range of oxygen concentrations and in the absence and presence of cyanide, a fast phase, reflecting a rapid approach to an equilibrium, was observed.	Oxygen	214-220	cytochrome c, somatic	Homo sapiens	40-52
168879-0	1975	Kinetic studies on the reaction between cytochrome c oxidase and ferrocytochrome c. In stopped-flow experiments in which oxidized cytochrome c oxidase was mixed with ferrocytochrome c in the presence of a range of oxygen concentrations and in the absence and presence of cyanide, a fast phase, reflecting a rapid approach to an equilibrium, was observed.	Oxygen	214-220	cytochrome c, somatic	Homo sapiens	70-82
1115709-0	1975	Changes in haptoglobin and other plasma proteins of rats during exposure to pure oxygen at 760 torr.	Oxygen	81-87	haptoglobin	Rattus norvegicus	11-22
1148470-0	1975	A quantitative analysis of oxygen release due to changes in P50 and venous PO2.	Oxygen	27-33	nuclear factor kappa B subunit 1	Homo sapiens	60-63
1148470-1	1975	It is almost impossible to estimate the amount of oxygen released from hemoglobin on the basis of the P50 values without calculation, because of the shape of the oxygen dissociation curve.	Oxygen	50-56	nuclear factor kappa B subunit 1	Homo sapiens	102-105
1148470-2	1975	For this reason, we prepared two tables : one indicating the saturation of hemoglobin with oxygen in the venous blood as influenced by venous Po2 and P50 (Table I) and the other, the oxygen release from the arterial blood as influenced by venous Po2 and P50 (Table II).	Oxygen	91-97	nuclear factor kappa B subunit 1	Homo sapiens	150-153
1115775-3	1975	The effect of thrombin on the oxygen consumption of washed human platelets was measured polarographically with the Clark oxygen electrode.	Oxygen	30-36	coagulation factor II, thrombin	Homo sapiens	14-22
1115775-3	1975	The effect of thrombin on the oxygen consumption of washed human platelets was measured polarographically with the Clark oxygen electrode.	Oxygen	121-127	coagulation factor II, thrombin	Homo sapiens	14-22
1115775-6	1975	Thrombin (1.9 units/ml) caused a 4-13-fold increase in the rate of oxygen consumption (138 plus or minus 14 (mean plus or minus S.E.)	Oxygen	67-73	coagulation factor II, thrombin	Homo sapiens	0-8
1115775-8	1975	The thrombin-stimulated increase of oxygen consumption was transient, lasting from 1 to 1.5 min before returning to the respiratory rate observed before the thrombin addition.	Oxygen	36-42	coagulation factor II, thrombin	Homo sapiens	4-12
1115775-8	1975	The thrombin-stimulated increase of oxygen consumption was transient, lasting from 1 to 1.5 min before returning to the respiratory rate observed before the thrombin addition.	Oxygen	36-42	coagulation factor II, thrombin	Homo sapiens	157-165
1115776-2	1975	Effect of inhibitors on thrombin-induced oxygen burst.	Oxygen	41-47	coagulation factor II, thrombin	Homo sapiens	24-32
1115776-4	1975	Cyanide (0.2 mM) caused complete inhibition of the basal respiration, but only 15% inhibition of the thrombin-stimulated burst of oxygen consumption.	Oxygen	130-136	coagulation factor II, thrombin	Homo sapiens	101-109
1115776-6	1975	Prostaglandin E1 (0.03 mM) and acetylsalicylic acid (0.8 mM) had little effect on basal respiration, but inhibited the thrombin-stimulated burst of oxygen consumption.	Oxygen	148-154	coagulation factor II, thrombin	Homo sapiens	119-127
1115776-8	1975	Our results provide evidence that basal respiration and a portion of the thrombin-stimulated burst of oxygen consumption are involved in respiratory chain phosphorylation, and that this component of the thrombin-stimulated burst may be coupled to the maintenance of the release reaction.	Oxygen	102-108	coagulation factor II, thrombin	Homo sapiens	73-81
1115776-8	1975	Our results provide evidence that basal respiration and a portion of the thrombin-stimulated burst of oxygen consumption are involved in respiratory chain phosphorylation, and that this component of the thrombin-stimulated burst may be coupled to the maintenance of the release reaction.	Oxygen	102-108	coagulation factor II, thrombin	Homo sapiens	203-211
241191-3	1975	They decided to substitute the offer of oxygen by adding a supply of cytochrome c and NADP, i.e. by substances that give a boost to the oxidoreduction processes within the cell.	Oxygen	40-46	cytochrome c, somatic	Homo sapiens	69-81
234927-3	1975	In 17/72 patients, simultaneous measurements of oxygen affinity for hemoglobin as characterized by P50 (oxygen tension at 50% O-2 saturation) corrected to in vivo arterial pH decreased from a mean of 26.4 to 25.2 mm Hg (p smaller than .01).	Oxygen	104-110	nuclear factor kappa B subunit 1	Homo sapiens	99-102
163252-9	1975	It is enzymically inactive in catalyzing the oxidation of reduced cytochrome c by molecular oxygen.	Oxygen	92-98	cytochrome c, somatic	Homo sapiens	66-78
803813-1	1975	A method is described for determining low concentrations of hydrogen peroxide by using a polarographic oxygen electrode to measure the oxygen released into solution on addition of catalase.	Oxygen	103-109	catalase	Homo sapiens	180-188
803813-1	1975	A method is described for determining low concentrations of hydrogen peroxide by using a polarographic oxygen electrode to measure the oxygen released into solution on addition of catalase.	Oxygen	135-141	catalase	Homo sapiens	180-188
1111681-1	1975	Compensatory mechanisms in children with iron-deficiency anemia were evaluated by measuring erythrocytic organic phosphates and, in some cases, shifts in the P50 of the oxygen dissociation curve.	Oxygen	169-175	nuclear factor kappa B subunit 1	Homo sapiens	158-161
234500-3	1975	The method enables the hemoglobin-oxygen dissociation curve to be measured on 10 to 20 mul of whole blood, and has given values for the P50 (the oxygen tension at 50 per cent hemoglobin-oxygen saturation) of 25.9 plus or minus  1.5 S. D. which are comparable to the value of 26.0 plus or minus 1.0 S. D. obtained by the mixing technique and by other methods.	Oxygen	145-151	nuclear factor kappa B subunit 1	Homo sapiens	136-139
234500-3	1975	The method enables the hemoglobin-oxygen dissociation curve to be measured on 10 to 20 mul of whole blood, and has given values for the P50 (the oxygen tension at 50 per cent hemoglobin-oxygen saturation) of 25.9 plus or minus  1.5 S. D. which are comparable to the value of 26.0 plus or minus 1.0 S. D. obtained by the mixing technique and by other methods.	Oxygen	145-151	nuclear factor kappa B subunit 1	Homo sapiens	136-139
1090149-7	1975	Further studies suggest that erythropoietin formation involves a phase of oxygen sensing and programming and a phase of synthesis.	Oxygen	74-80	erythropoietin	Homo sapiens	29-43
168750-8	1975	Two electrons are taken up per molecule of cytochrome P-450 from dithionite or from NADPH in the presence of catalytic amounts of the reductase, and both electrons are readily transferred from the reduced cytochrome P-450 to molecular oxygen or artificial electron acceptors.	Oxygen	235-241	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	43-59
168750-8	1975	Two electrons are taken up per molecule of cytochrome P-450 from dithionite or from NADPH in the presence of catalytic amounts of the reductase, and both electrons are readily transferred from the reduced cytochrome P-450 to molecular oxygen or artificial electron acceptors.	Oxygen	235-241	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	205-221
168750-9	1975	The reconstituted enzyme system containing purified cytochrome P-450, purified NADPH-cytochrome P-450 reductase, and phosphatidylcholine retains the ability to catalyze the hydroxylation of drugs, fatty acids, hydrocarbons, and aniline in the presence of NADPH and molecular oxygen.	Oxygen	275-281	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	52-68
1719-0	1975	[Study of P50 in patients under continuous O2 inhalation and during chronic respiratory acidosis].	Oxygen	43-45	nuclear factor kappa B subunit 1	Homo sapiens	10-13
234608-3	1975	This difference in oxygen affinity was explained by differences in 2,3-DPG: 1.08 plus or minus 0.02 SEM in males, 1.24 plus or minus 0.03 in non-pregnant females and 1.34 plus or minus 0.03 mol/mol HB in pregnant females P50, 2,3-DPG and haemoglobin concentrations were significantly correlated for the ensemble of the 3 groups.	Oxygen	19-25	neuronal pentraxin-2	Cavia porcellus	221-224
1101091-1	1975	Erythropoietin is a polypeptide hormone, which is produced in response to a deficit in the delivery of oxygen to the tissues relative to their oxygen needs; although other feedback mechanisms also modulate its production.	Oxygen	103-109	erythropoietin	Homo sapiens	0-14
1101091-1	1975	Erythropoietin is a polypeptide hormone, which is produced in response to a deficit in the delivery of oxygen to the tissues relative to their oxygen needs; although other feedback mechanisms also modulate its production.	Oxygen	143-149	erythropoietin	Homo sapiens	0-14
4146221-0	1973	Cytochrome c enhancement of singlet molecular oxygen production by the NADPH-dependent adrenodoxin reductase-adrenodoxin system: the role of singlet oxygen in damaging adrenal mitochondrial membranes.	Oxygen	46-52	cytochrome c, somatic	Homo sapiens	0-12
1208304-3	1975	The affinity of blood for O2, evaluated by the determination of P50 (PO2 of half saturation of Hb) interfers also, but we have till presently no precision for what concerns its relative importance.	Oxygen	26-28	nuclear factor kappa B subunit 1	Homo sapiens	64-67
1208304-6	1975	Authors insist particularly on the fact that the fall in the affinity of Hb for O2 (increase in P50) is not always a beneficial mechanism for the delivery of O2 to tissues, particularly in the case of severe hypoxia.	Oxygen	80-82	nuclear factor kappa B subunit 1	Homo sapiens	96-99
1162297-2	1975	Oxygen intake at a given submaximal work level of 450 kmp min-1 and cardiac frequency at an oxygen intake of 1.5 I min-1 were significantly higher (p less than 0.001) in the injured compared with the uninjured limbs of the patients and normal subjects.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
1162297-2	1975	Oxygen intake at a given submaximal work level of 450 kmp min-1 and cardiac frequency at an oxygen intake of 1.5 I min-1 were significantly higher (p less than 0.001) in the injured compared with the uninjured limbs of the patients and normal subjects.	Oxygen	92-98	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
1224006-2	1975	Hydrogen peroxide is formed during this process, and the amount formed can be calculated from the amount of oxygen produced upon the addition of catalase.	Oxygen	108-114	catalase	Rattus norvegicus	145-153
4817267-0	1974	Proceedings: The effects of variations in P50 on oxygen transport in chronic hypoxic lung didease.	Oxygen	49-55	nuclear factor kappa B subunit 1	Homo sapiens	42-45
5428888-0	1970	Plasma insulin concentrations during prolonged work at near maximal oxygen uptake.	Oxygen	68-74	insulin	Homo sapiens	7-14
5080413-6	1972	The reciprocal interdependence of oxygen delivery and effective erythropoiesis was documented by alterations in erythropoietin excretion, quantitative iron kinetics, and reticulocyte production in response to phlebotomy-induced reduction in the oxygen-carrying capacity.	Oxygen	34-40	erythropoietin	Homo sapiens	112-126
4483956-0	1972	Hazard: Sav-a-life oxygen containers.	Oxygen	19-25	salvador family WW domain containing protein 1	Homo sapiens	8-11
4327641-0	1971	[Oxygen tension and activity of respiratory enzymes in the skeletal muscles following administration of ACTH and hydrocortisone].	Oxygen	1-7	proopiomelanocortin	Homo sapiens	104-108
11947594-0	1970	Effect of non-haem iron proteins and cytochrome C from Azotobacter upon the activity and oxygen sensitivity of Azobacter nitrogenase.	Oxygen	89-95	cytochrome c, somatic	Homo sapiens	37-49
4721622-0	1973	Kinetics of the reaction between oxygen and haemoglobin bound to haptoglobin.	Oxygen	33-39	haptoglobin	Homo sapiens	65-76
4768277-0	1973	[Bone marrow oxygen consumption under the action of erythropoietin and erythrocyte decomposition products on the erythron].	Oxygen	13-19	erythropoietin	Homo sapiens	52-66
4655429-8	1972	At limiting concentrations of O(2), the spectral changes are accelerated by catalase, indicating that H(2)O(2) is one of the reaction products.	Oxygen	30-34	catalase	Homo sapiens	76-84
4403392-0	1972	Stimulation of oxygen uptake of ferredoxin-NADP reductase-ferredoxin complex by cytochrome c.	Oxygen	15-21	cytochrome c, somatic	Homo sapiens	80-92
4323392-0	1970	[The effect of adrenocorticotropic hormone on renal oxygen tension].	Oxygen	52-58	proopiomelanocortin	Homo sapiens	15-42
5449131-2	1970	Lactoperoxidase (EC 1.11.1.7), an enzyme present in various mammalian glands and in their secretions, catalyses the oxidation of thiocyanate by hydrogen peroxide to form a compound that inhibits the growth, oxygen uptake and acid production of certain bacteria.	Oxygen	207-213	lactoperoxidase	Homo sapiens	0-15
5391442-0	1969	[The effect of hyperbaric oxygen on ERG].	Oxygen	26-32	ETS transcription factor ERG	Homo sapiens	36-39
16657096-4	1969	The presence of cytochrome c and a small amount of a-type cytochrome is determined in these cells.Light-induced oxidation of cytochrome b(563) is eliminated by oxygen-induced oxidation, and oxygen-induced oxidation is greatly diminished under illumination.	Oxygen	160-166	cytochrome c, somatic	Homo sapiens	16-28
4907320-0	1969	Oxygen consumption of the membranous cochlea and other tissues in shaker-1 (sh-1-sh-1) and normal (CBA-J-CBA-J) mice.	Oxygen	0-6	myosin VIIA	Mus musculus	66-74
5796352-6	1969	The erythrocytosis in carriers of hemoglobins Rainer and Yakima appears to be secondary to the increased oxygen affinity and this, with the response to phlebotomy, is consistent with the postulate that the renal sensor tissue regulating erythropoietin production is primarily influenced by the oxygen tensions of venous rather than arterial blood.	Oxygen	294-300	erythropoietin	Homo sapiens	237-251
5307435-0	1969	Hydrogen ion uptake by oxygen atoms released from rhodopsin molecules on illumination.	Oxygen	23-29	rhodopsin	Homo sapiens	50-59
4980717-5	1969	When the serum albumin is in excess, oxygen is not absorbed and the products are colourless.	Oxygen	37-43	albumin	Homo sapiens	9-22
4980717-8	1969	When bovine serum albumin reacts with excess of chlorogenoquinone, oxygen is absorbed and the products are red.	Oxygen	67-73	albumin	Homo sapiens	12-25
16657096-4	1969	The presence of cytochrome c and a small amount of a-type cytochrome is determined in these cells.Light-induced oxidation of cytochrome b(563) is eliminated by oxygen-induced oxidation, and oxygen-induced oxidation is greatly diminished under illumination.	Oxygen	190-196	cytochrome c, somatic	Homo sapiens	16-28
5697987-0	1968	Effect of oxygen deficiency on cytochrome c, heme a, and iron protoporphyrin of L-cells.	Oxygen	10-16	cytochrome c, somatic	Homo sapiens	31-43
4986671-0	1969	[Oxygen consumption of a Bacillus subtilis culture during transition from NH4 to NO3 assimilation].	Oxygen	1-7	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
4385509-1	1968	Interaction between oxygen and bradykinin.	Oxygen	20-26	kininogen 1	Homo sapiens	31-41
5690111-1	1968	Bradykinin is a potent constrictor of the human umbilical artery and vein and the ductus arteriosus of the lamb in vitro at oxygen tensions above 40 mm Hg (comparable to those in the newborn infant).	Oxygen	124-130	kininogen 1	Homo sapiens	0-10
5723299-0	1968	A method for assay of catalase with the oxygen cathode.	Oxygen	40-46	catalase	Homo sapiens	22-30
5642615-10	1968	The spinach enzyme was inactive in aerobic conditions and it was shown by using an oxygen electrode that under such conditions the addition of Fe(2+) to buffer solutions caused a rapid uptake of dissolved oxygen, believed to be due to the oxidation of Fe(2+) to Fe(3+); Fe(3+) is not a substrate for ferrochelatase.	Oxygen	205-211	ferrochelatase	Rattus norvegicus	300-314
5693425-0	1968	[The effects of oral antidiabetic agents and insulin on oxygen consumption and anaerobic glycolysis of several tissues].	Oxygen	56-62	insulin	Homo sapiens	45-52
4867577-0	1968	Research with the isotopes of oxygen (O15, O17 and O18) during 1963-1966.	Oxygen	30-36	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	38-41
5231424-0	1967	The high oxygen mixtures delivered by the air-mix control of the Bird Mark 7 ventilator.	Oxygen	9-15	microtubule affinity regulating kinase 1	Homo sapiens	70-74
5973785-0	1966	On the connection between the catalase activity and the consumption of molecular oxygen by isolated chloroplasts.	Oxygen	81-87	catalase	Homo sapiens	30-38
4287485-16	1966	(iii) The consequences of insulin-membrane interaction are both immediate and sustained, and, under appropriate conditions, they are reflected in the affinity of intracellular haemoglobin for oxygen.6.	Oxygen	192-198	insulin	Homo sapiens	26-33
5840797-5	1965	However, employing an indirect method for the estimation of sodium transport (oxygen consumption), it is possible to show that vasopressin exerts its usual effect on Q(oo2) when sodium is present in the bathing medium.	Oxygen	78-84	arginine vasopressin	Homo sapiens	127-138
5854086-0	1965	[Possible role of catalase in the preservation of the native status of proteins in oxygen-containing solutions].	Oxygen	83-89	catalase	Homo sapiens	18-26
14308009-0	1965	THE DEVELOPMENTAL RATE AND OXYGEN CONSUMPTION OF SNAIL EGGS AT VARIOUS TEMPERATURES.	Oxygen	27-33	snail family transcriptional repressor 1	Homo sapiens	49-54
14273688-0	1965	SIMPLE METHOD OF ANAEROBIC CULTIVATION, WITH REMOVAL OF OXYGEN BY A BUFFERED GLUCOSE OXIDASE-CATALASE SYSTEM.	Oxygen	56-62	catalase	Homo sapiens	93-101
13948718-0	1963	Effect of high oxygen concentrations on erythropoietin and the renal juxtaglomerular cell.	Oxygen	15-21	erythropoietin	Homo sapiens	40-54
14219017-8	1964	Catalase activity was increased three to five times by growing cultures under conditions of oxygen availability; however, aeration had no beneficial effect on total viable cell crop.	Oxygen	92-98	catalase	Homo sapiens	0-8
4221674-0	1965	[On the relationships existing between oxygen partial pressure in the hemolymph and the activity of the isolated snail ventricle].	Oxygen	39-45	snail family transcriptional repressor 1	Homo sapiens	113-118
13990165-0	1962	[On the influence of cytochrome C on oxygen consumption of normal and carbon monoxide-poisoned organs].	Oxygen	37-43	cytochrome c, somatic	Homo sapiens	21-33
13937070-0	1963	Relation between erythropoietin plasma level and oxygen requirements.	Oxygen	49-55	erythropoietin	Homo sapiens	17-31
13949951-0	1962	Substrate interchanges and oxygen transfers catalyzed by glutamine synthetase at equilibrium.	Oxygen	27-33	glutamate-ammonia ligase	Homo sapiens	57-77
14452808-0	1962	Studies on the metabolism of adipose tissue; the stimulation of oxygen consumption by TSH preparations in relation to growth hormone and other pituitary fractions.	Oxygen	64-70	growth hormone 1	Homo sapiens	118-132
13707535-0	1961	Separation of insulin effects on K content and O2 consumption of frog muscle with cardiac glycosides.	Oxygen	47-49	insulin	Homo sapiens	14-21
14452807-2	1961	A comparison of the effects of insulin and a growth-hormone preparation on oxygen consumption in bicarbonate and phosphate buffers.	Oxygen	75-81	growth hormone 1	Homo sapiens	45-59
13652477-0	1959	[Effect of the intracellular phosphate (P31 & P32) concentration on oxygen consumption in a strain of Proteus & its fixed L form].	Oxygen	72-78	ATPase H+ transporting V1 subunit E1	Homo sapiens	40-43
13682358-2	1961	Influence of oxygen and absorbed water on changes produced in bovine serum albumin.	Oxygen	13-19	albumin	Homo sapiens	69-82
14408192-1	1960	V. The effect of a growth hormone preparation and insulin on the oxygen consumption, glucose uptake, and lactic acid production.	Oxygen	65-71	insulin	Homo sapiens	50-57
13818905-0	1960	The effect of cytochrome C on the oxygen consumption of tissues of normal and CO-poisoned animals.	Oxygen	34-40	cytochrome c, somatic	Homo sapiens	14-26
13509678-0	1958	[Treatment of oxygen deficiency states in children with cytochrome c].	Oxygen	14-20	cytochrome c, somatic	Homo sapiens	56-68
13473872-0	1957	Effect of low oxygen duration and liver damage on plasma erythropoietin titer in hypoxic animals.	Oxygen	14-20	erythropoietin	Homo sapiens	57-71
13597267-0	1958	[Role of cytochrome c in the transfer of oxygen of peroxide].	Oxygen	41-47	cytochrome c, somatic	Homo sapiens	9-21
13609101-0	1958	[The role of the catalase-reduced cytochrome system in the transfer of peroxide oxygen].	Oxygen	80-86	catalase	Homo sapiens	17-25
13364718-0	1956	The potassium uptake and rate of oxygen consumption of isolated frog skeletal muscle in the presence of insulin and lactate.	Oxygen	33-39	insulin	Homo sapiens	104-111
13445774-0	1956	[Activity of glutamine-synthetase of the brain and liver following exposure of animals to high oxygen pressure].	Oxygen	95-101	glutamate-ammonia ligase	Homo sapiens	13-33
13295305-2	1956	The span cytochrome c to oxygen.	Oxygen	25-31	cytochrome c, somatic	Homo sapiens	9-21
13317589-0	1956	[Mechanism of action of cytochrome c in anesthesia and in various oxygen deficiency states].	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	24-36
13319293-0	1956	Transfer of oxygen in the glutamine synthetase reaction.	Oxygen	12-18	glutamate-ammonia ligase	Homo sapiens	26-46
14377674-0	1955	[Influence of hydrogen ion concentration and of oxygen and carbon dioxide tensions on the hexokinase and phosphatase activities of homogenates of intestinal mucosa].	Oxygen	48-54	hexokinase 1	Homo sapiens	90-100
13245457-0	1955	[Effects in vitro and in vivo of various hormones (cortisone, ACTH, desoxycorticosterone, somatotrophic hormone, testosterone) on oxygen consumption by renal tissue].	Oxygen	130-136	proopiomelanocortin	Homo sapiens	62-66
13207380-0	1954	Stimulation of oxygen consumption by insulin in intact isolated frog muscle.	Oxygen	15-21	insulin	Homo sapiens	37-44
13218177-0	1954	Role of citrate in stimulation of oxygen consumption by insulin in frog muscle.	Oxygen	34-40	insulin	Homo sapiens	56-63
14932465-0	1952	[Decrease of insulin resistance by subcutaneous administration of oxygen in the active treatment of psychoses].	Oxygen	66-72	insulin	Homo sapiens	13-20
13168375-0	1954	The effect of insulin on the oxygen consumption of mammalian muscle.	Oxygen	29-35	insulin	Homo sapiens	14-21
13080439-0	1953	Effect of ACTH on rate of oxygen consumption in experimental traumatic shock.	Oxygen	26-32	proopiomelanocortin	Homo sapiens	10-14
13093720-2	1953	Reaction of oxygen carrying enzyme isolated in cholate solution with cytochrome c and oxygen].	Oxygen	12-18	cytochrome c, somatic	Homo sapiens	69-81
13019827-0	1952	The effect of the intravenous administration of cytochrome c or of ferric iron upon the oxygen debt in heart patients.	Oxygen	88-94	cytochrome c, somatic	Homo sapiens	48-60
14474343-2	1961	The system: reducing agent-cytochrome c-cytochrome oxidase-oxygen.	Oxygen	59-65	cytochrome c, somatic	Homo sapiens	27-39
14894657-0	1951	In vitro oxygen consumption of the various zones of adrenal cortex as affected by ACTH.	Oxygen	9-15	proopiomelanocortin	Homo sapiens	82-86
16993672-0	1924	The effect of insulin on the oxygen and carbon dioxide tensions in air between the skin and the muscles.	Oxygen	29-35	insulin	Homo sapiens	14-21
18122269-0	1949	Carbon dioxide and oxygen in complex formation with iron and siderophilin, the iron-binding component of human plasma.	Oxygen	19-25	transferrin	Homo sapiens	61-73
14793503-0	1950	EFFECTS of purified ACTH added in vitro on the oxygen consumption and ascorbic acid content of surviving dog adrenal slices.	Oxygen	47-53	proopiomelanocortin	Canis lupus familiaris	20-24
18893572-0	1948	The oxygen content of coronary venous blood as affected by anoxia and cytochrome c.	Oxygen	4-10	cytochrome c, somatic	Homo sapiens	70-82
16994530-0	1934	The action of insulin on the r.q., oxygen utilization, CO(2) production and sugar utilization in the mammalian diabetic heart.	Oxygen	35-41	insulin	Homo sapiens	14-21
33865947-8	2021	Enhanced cell death and GSH depletion in Calu-6 cells caused by the MEK inhibitor were related to increased O2 - levels, and the effects of the p38 inhibitor in A549 cells were correlated with increased general ROS levels.	Oxygen	108-112	mitogen-activated protein kinase kinase 7	Homo sapiens	68-71
33683657-9	2021	IL-24 expression increased significantly in rat lungs exposed to hyperoxia and FATIICs exposed to oxygen or LPS.	Oxygen	98-104	interleukin 24	Rattus norvegicus	0-5
33836322-12	2021	Low albumin, vitamin D, magnesium ,vitamin B12, Se status were associated with malnutrition, oxygen therapy and/or intensive care support of the patients, survival of COVID -19.	Oxygen	93-99	albumin	Homo sapiens	4-11
33926775-6	2021	Furthermore, IFNG exhibited potent anti-angiogenic efficacy in the mouse model of oxygen-induced retinopathy (OIR), an in vivo model for hypoxia-induced retinal neovascularization, without induction of functional side effects.	Oxygen	82-88	interferon gamma	Mus musculus	13-17
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	157-163	caspase 1	Homo sapiens	45-54
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	204-210	caspase 1	Homo sapiens	45-54
33993479-1	2021	"CXCL16 protects against oxygen and glucose deprivation-induced injury in human microvascular endothelial cells-1: Potential role in ischemic stroke," by Min Wang, Ruiting Liu, J Cell Physiol.	Oxygen	25-31	C-X-C motif chemokine ligand 16	Homo sapiens	1-7
33836346-1	2021	OBJECTIVE: To investigate the effect and significance of mammalian target of rapamycin (mTOR) inhibitors on the expression of alpha-SMA in lung injury induced by high volume fraction of inspired oxygen (hyperoxygen) in SD rat pups.	Oxygen	195-201	mechanistic target of rapamycin kinase	Homo sapiens	57-86
33836346-1	2021	OBJECTIVE: To investigate the effect and significance of mammalian target of rapamycin (mTOR) inhibitors on the expression of alpha-SMA in lung injury induced by high volume fraction of inspired oxygen (hyperoxygen) in SD rat pups.	Oxygen	195-201	mechanistic target of rapamycin kinase	Homo sapiens	88-92
33836346-1	2021	OBJECTIVE: To investigate the effect and significance of mammalian target of rapamycin (mTOR) inhibitors on the expression of alpha-SMA in lung injury induced by high volume fraction of inspired oxygen (hyperoxygen) in SD rat pups.	Oxygen	195-201	actin alpha 1, skeletal muscle	Homo sapiens	126-135
33683657-5	2021	The authors quantified IL-24 expression in the lungs of newborn rat pups exposed to hyperoxia (70% oxygen) and in FATIICs isolated on embryonic day 19 that were exposed to 95% oxygen or lipopolysaccharide (LPS).	Oxygen	99-105	interleukin 24	Rattus norvegicus	23-28
33850550-9	2021	These effects were induced by the activation of the AMP-activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response.	Oxygen	260-266	mechanistic target of rapamycin kinase	Homo sapiens	157-186
33850550-9	2021	These effects were induced by the activation of the AMP-activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response.	Oxygen	260-266	mechanistic target of rapamycin kinase	Homo sapiens	188-192
33896195-1	2021	Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels.	Oxygen	220-226	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
31216951-7	2021	The time with an oxygen uptake above 35 ml kg-1 min-1 was longer in the new test, 6.4 vs 4.7 min.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	48-53
33355497-0	2021	Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway.	Oxygen	42-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	113-117
33217156-0	2021	Hb Angers: A new alpha2-globin variant [alpha2 (140)(HC2) Tyr   Ser; HBA2: C.422 A>C] with increased oxygen affinity leading to erythrocytosis.	Oxygen	101-107	glycoprotein hormone subunit alpha 2	Homo sapiens	17-23
33652022-8	2021	Hypoxia (1% O2, 24 h)-induced killing effects of Txnip were decreased by lower levels of cellular ROS in Txnip C247S-expressing cells compared with wild-type Txnip-expressing cells.	Oxygen	12-14	thioredoxin interacting protein	Mus musculus	49-54
33892380-3	2021	In THB1, the latter site is occupied by Lys53, which is likely to facilitate Fe(II)/Fe(III) redox cycling but hinders dioxygen binding, two features inherent to the NO dioxygenase activity of the protein.	Oxygen	118-126	uncharacterized protein	Chlamydomonas reinhardtii	3-7
33652022-8	2021	Hypoxia (1% O2, 24 h)-induced killing effects of Txnip were decreased by lower levels of cellular ROS in Txnip C247S-expressing cells compared with wild-type Txnip-expressing cells.	Oxygen	12-14	thioredoxin interacting protein	Mus musculus	105-110
33652022-8	2021	Hypoxia (1% O2, 24 h)-induced killing effects of Txnip were decreased by lower levels of cellular ROS in Txnip C247S-expressing cells compared with wild-type Txnip-expressing cells.	Oxygen	12-14	thioredoxin interacting protein	Mus musculus	105-110
33782532-0	2021	Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice.	Oxygen	114-120	tenascin XB	Mus musculus	143-153
34000476-0	2021	Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells invasion and migration.	Oxygen	82-88	solute carrier family 9 member A1	Homo sapiens	108-124
33786616-0	2021	Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation-induced HT22 cells by activating the Nrf2/HO-1 pathway.	Oxygen	60-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146
33786616-0	2021	Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation-induced HT22 cells by activating the Nrf2/HO-1 pathway.	Oxygen	60-66	heme oxygenase 1	Mus musculus	147-151
33901885-7	2021	Quantitative real-time PCR (qRT-PCR) and biochemical assays showed that HRW induced the transcripts and enzymatic activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT) that metabolize reactive oxygen species (ROS); these increases coincided with the observed changes in O2.-, H2O2 and  OH accumulation upon GA treatment.	Oxygen	305-307	superoxide dismutase 1	Homo sapiens	128-148
33865914-4	2021	Similarly, Drosophila globin1 (a homologue of human globin) with its known roles in oxygen management and development of nervous system exhibits striking similarities with the mammalian neuroglobin.	Oxygen	84-90	globin 1	Drosophila melanogaster	22-29
33106922-0	2021	Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.	Oxygen	9-15	epidermal growth factor receptor	Homo sapiens	86-118
33106922-0	2021	Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.	Oxygen	9-15	epidermal growth factor receptor	Homo sapiens	120-124
33106922-1	2021	PURPOSE: Epidermal growth factor receptor (EGFR) amplification promotes gliomagenesis and is linked to lack of oxygen within the tumor microenvironment.	Oxygen	111-117	epidermal growth factor receptor	Homo sapiens	9-41
33106922-1	2021	PURPOSE: Epidermal growth factor receptor (EGFR) amplification promotes gliomagenesis and is linked to lack of oxygen within the tumor microenvironment.	Oxygen	111-117	epidermal growth factor receptor	Homo sapiens	43-47
33106922-2	2021	Using hypoxia-sensitive spin-and-gradient echo echo-planar imaging and perfusion MRI, we investigated the influence of EGFR amplification on tissue oxygen availability and utilization in human gliomas.	Oxygen	148-154	epidermal growth factor receptor	Homo sapiens	119-123
33106922-14	2021	CONCLUSION: Imaging of tumor oxygen characteristics revealed EGFR-amplified gliomas to be more hypoxic and contribute to shorter patient survival than EGFR non-amplified gliomas.	Oxygen	29-35	epidermal growth factor receptor	Homo sapiens	61-65
34056870-8	2021	RESULTS: Surgical debridement, antibiotic, and hyperbaric oxygen therapy were used and discontinued over a 6-month period with normalization of C-reactive protein.	Oxygen	58-64	C-reactive protein	Homo sapiens	144-162
33838154-0	2021	Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells.	Oxygen	44-50	NFE2 like bZIP transcription factor 1	Homo sapiens	77-83
33632987-10	2021	HIF1alpha expression in hES-MSCs peaked after 48 h of incubation in 1% O2 condition.	Oxygen	71-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
33632987-11	2021	The expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin were increased after hES-MSCs were incubated for 48 h in 2% O2 condition.	Oxygen	120-122	vascular endothelial growth factor A	Homo sapiens	37-43
33632987-12	2021	Conclusions: The hES-MSCs viability and expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin increased after 48 h incubation in 2% O2 condition.	Oxygen	134-136	vascular endothelial growth factor A	Homo sapiens	73-79
33830565-8	2021	(iii) High levels of Wnt5a, sFRP3, DKK3 and WIF1 were associated with poor prognosis in age- and sex-adjusted analysis (hazard ratios per log/SD change ~1.4) and for DKK3 after further adjustment with right arterial pressure, pulmonary oxygen saturation, cardiac index, N-terminal pro B-type natriuretic peptide and peak oxygen uptake (VO2 ).	Oxygen	236-242	Wnt family member 5A	Homo sapiens	21-26
33830565-8	2021	(iii) High levels of Wnt5a, sFRP3, DKK3 and WIF1 were associated with poor prognosis in age- and sex-adjusted analysis (hazard ratios per log/SD change ~1.4) and for DKK3 after further adjustment with right arterial pressure, pulmonary oxygen saturation, cardiac index, N-terminal pro B-type natriuretic peptide and peak oxygen uptake (VO2 ).	Oxygen	321-327	Wnt family member 5A	Homo sapiens	21-26
33960375-8	2021	D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine.	Oxygen	198-204	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	12-16
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	48-54	DNA damage inducible transcript 3	Homo sapiens	205-209
33961402-1	2021	Copper-zinc superoxide dismutase (SOD1) is a major antioxidant metalloenzyme that protects cells from oxidative damage by superoxide anions (O2-).	Oxygen	141-144	superoxide dismutase 1	Homo sapiens	34-38
33619534-6	2021	Mechanistically, Twist1 deletion induces transactivation of voltage-gated calcium channel (VGCC) Cacna1b which exhausts Ly-biased HSCs, impairs genotoxic hematopoietic recovery, and enhances mitochondrial calcium levels, metabolic activity, and reactive oxygen species production.	Oxygen	254-260	twist family bHLH transcription factor 1	Homo sapiens	17-23
34052343-1	2021	Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively.	Oxygen	142-146	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	218-240
34052343-1	2021	Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively.	Oxygen	142-146	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	242-245
34035373-0	2021	A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.	Oxygen	47-53	cytoglobin	Homo sapiens	64-74
34027895-2	2021	Oxygen tension is an environmental cue that distinguishes peripheral tissues from the circulation, and here, we demonstrate that differentiation of human CD8+ T cells in the presence of hypoxia and TGF-beta1 led to the development of a TRM phenotype, characterized by a greater than 5-fold increase in CD69+CD103+ cells expressing human TRM hallmarks and enrichment for endogenous human TRM gene signatures, including increased adhesion molecule expression and decreased expression of genes involved in recirculation.	Oxygen	0-6	transforming growth factor beta 1	Homo sapiens	198-207
34003380-0	2021	Simultaneous hyperbaric oxygen therapy during systemic chemotherapy reverses chemotherapy-induced peripheral neuropathy by inhibiting TLR4 and TRPV1 activation in the central and peripheral nervous system.	Oxygen	24-30	toll-like receptor 4	Rattus norvegicus	134-138
34019639-8	2021	Mitochondrial oxygen consumption under low-glucose conditions was also reduced ~58% in islets from TAZ KD animals.	Oxygen	14-20	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	99-102
34008401-3	2021	Moreover, the formation of the Cys-Tyr cofactor requires the metal cofactor (Fe2+) and O2, and it was previously considered to substantially enhance the catalytic efficiency and half-life of CDO.	Oxygen	87-89	cell adhesion associated, oncogene regulated	Homo sapiens	191-194
34008401-7	2021	In F2-CDO, the cofactor formation contains the H-abstraction, C-S bond formation, intramolecular F migration, and aromatization of the residue F2Y157, in which the Fe-coordinate dioxygen can be recovered after the formation cofactor; however, in the WT-CDO, the cofactor formation shows some differences.	Oxygen	178-186	cell adhesion associated, oncogene regulated	Homo sapiens	3-9
34008401-7	2021	In F2-CDO, the cofactor formation contains the H-abstraction, C-S bond formation, intramolecular F migration, and aromatization of the residue F2Y157, in which the Fe-coordinate dioxygen can be recovered after the formation cofactor; however, in the WT-CDO, the cofactor formation shows some differences.	Oxygen	178-186	cell adhesion associated, oncogene regulated	Homo sapiens	6-9
34009435-14	2021	Compared with the no-exercise group, peak oxygen uptake improved after both morning (estimated effect 1.3 ml min-1 kg-1 [95% CI 0.5, 2.0], p = 0.003) and evening exercise (estimated effect 1.4 ml min-1 kg-1 [95% CI 0.6, 2.2], p = 0.001).	Oxygen	42-48	CD59 molecule (CD59 blood group)	Homo sapiens	109-119
34007068-4	2021	Here, we show a novel function of Arrb2: Arrb2 facilitates the degradation of HIF-1alpha, which is a master regulator of oxygen homeostasis.	Oxygen	121-127	arrestin beta 2	Homo sapiens	34-39
34007068-4	2021	Here, we show a novel function of Arrb2: Arrb2 facilitates the degradation of HIF-1alpha, which is a master regulator of oxygen homeostasis.	Oxygen	121-127	arrestin beta 2	Homo sapiens	41-46
34007068-4	2021	Here, we show a novel function of Arrb2: Arrb2 facilitates the degradation of HIF-1alpha, which is a master regulator of oxygen homeostasis.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
34007068-8	2021	These results collectively reveal a novel function of Arrb2 in the oxygen-sensing mechanism that directly regulates HIF-1alpha stability in human cancers and suggest Arrb2 as a new potential therapeutic target for glioblastoma.	Oxygen	67-73	arrestin beta 2	Homo sapiens	54-59
34007068-8	2021	These results collectively reveal a novel function of Arrb2 in the oxygen-sensing mechanism that directly regulates HIF-1alpha stability in human cancers and suggest Arrb2 as a new potential therapeutic target for glioblastoma.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
34007068-8	2021	These results collectively reveal a novel function of Arrb2 in the oxygen-sensing mechanism that directly regulates HIF-1alpha stability in human cancers and suggest Arrb2 as a new potential therapeutic target for glioblastoma.	Oxygen	67-73	arrestin beta 2	Homo sapiens	166-171
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	Oxygen	87-93	thymoma viral proto-oncogene 1	Mus musculus	173-176
34001853-4	2021	In addition, catalase expression was also reduced in CLL cells suggesting impairment of H2O2-conversion into water and O2 which may cause H2O2-accumulation.	Oxygen	90-92	catalase	Homo sapiens	13-21
34001853-7	2021	Functionally, ROS accumulation in CLL cells activated the AXL survival axis while upregulated SIRT3, suggesting that CLL cells rapidly remove highly reactive O2- to avoid its cytotoxic effect but maintain increased H2O2-level to promote cell survival.	Oxygen	158-161	sirtuin 3	Homo sapiens	94-99
34015428-9	2021	In conclusion, TLR-activated microglia can induce different levels of neuronal network dysfunction, in which severe dysfunction is mainly caused by reactive oxygen and nitrogen species rather than proinflammatory cytokines.	Oxygen	157-163	toll-like receptor 2	Rattus norvegicus	15-18
33900756-2	2021	Nonheme iron enzymes, superoxide reductase (SOR) and superoxide dismutase (SOD), detoxify O2 - via reduction to afford H2O2 and disproportionation to afford O2 and H2O2, respectively.	Oxygen	90-94	superoxide dismutase 1	Homo sapiens	53-73
33900756-2	2021	Nonheme iron enzymes, superoxide reductase (SOR) and superoxide dismutase (SOD), detoxify O2 - via reduction to afford H2O2 and disproportionation to afford O2 and H2O2, respectively.	Oxygen	90-94	superoxide dismutase 1	Homo sapiens	75-78
33900756-2	2021	Nonheme iron enzymes, superoxide reductase (SOR) and superoxide dismutase (SOD), detoxify O2 - via reduction to afford H2O2 and disproportionation to afford O2 and H2O2, respectively.	Oxygen	90-92	superoxide dismutase 1	Homo sapiens	53-73
33900756-2	2021	Nonheme iron enzymes, superoxide reductase (SOR) and superoxide dismutase (SOD), detoxify O2 - via reduction to afford H2O2 and disproportionation to afford O2 and H2O2, respectively.	Oxygen	90-92	superoxide dismutase 1	Homo sapiens	75-78
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	Oxygen	87-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	183-187
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	Oxygen	87-93	heme oxygenase 1	Mus musculus	188-192
33988258-2	2021	Recently, the reduction of prolyl hydroxylase domain-containing protein 2 (PHD2), a primary cellular oxygen sensor, has shown an incredible extensive effect on skeletal muscle tissue regeneration by improving cell resistance to reactive oxygen species, whereas its role in periodontal defect repair is unclear.	Oxygen	101-107	egl-9 family hypoxia inducible factor 1	Homo sapiens	27-73
34000750-15	2021	Oxygen extraction from the retinal capillaries was improved in patients who had injections with VEGF inhibitors.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	96-100
34000750-17	2021	CONCLUSION: The clinically observed improvement in the retinal state situation after intravitreal injections with VEGF inhibitors may be seen in association with the improved oxygen extraction.	Oxygen	175-181	vascular endothelial growth factor A	Homo sapiens	114-118
33988258-2	2021	Recently, the reduction of prolyl hydroxylase domain-containing protein 2 (PHD2), a primary cellular oxygen sensor, has shown an incredible extensive effect on skeletal muscle tissue regeneration by improving cell resistance to reactive oxygen species, whereas its role in periodontal defect repair is unclear.	Oxygen	101-107	egl-9 family hypoxia inducible factor 1	Homo sapiens	75-79
33988258-2	2021	Recently, the reduction of prolyl hydroxylase domain-containing protein 2 (PHD2), a primary cellular oxygen sensor, has shown an incredible extensive effect on skeletal muscle tissue regeneration by improving cell resistance to reactive oxygen species, whereas its role in periodontal defect repair is unclear.	Oxygen	237-243	egl-9 family hypoxia inducible factor 1	Homo sapiens	27-73
33992676-9	2021	Finally, when divided into three groups according to serum CRP levels, dose-dependent increases in the intracellular O2 - levels in blood cells and central memory and effector memory CD8+ T cells were most prominently observed in the high-CRP group.	Oxygen	117-121	C-reactive protein	Homo sapiens	59-62
33992676-9	2021	Finally, when divided into three groups according to serum CRP levels, dose-dependent increases in the intracellular O2 - levels in blood cells and central memory and effector memory CD8+ T cells were most prominently observed in the high-CRP group.	Oxygen	117-121	C-reactive protein	Homo sapiens	239-242
33988258-2	2021	Recently, the reduction of prolyl hydroxylase domain-containing protein 2 (PHD2), a primary cellular oxygen sensor, has shown an incredible extensive effect on skeletal muscle tissue regeneration by improving cell resistance to reactive oxygen species, whereas its role in periodontal defect repair is unclear.	Oxygen	237-243	egl-9 family hypoxia inducible factor 1	Homo sapiens	75-79
33986256-0	2021	Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-114
33956021-0	2021	A highly efficient Fe-Ni-S/NF hybrid electrode for promoting oxygen evolution performance.	Oxygen	61-67	solute carrier family 5 member 5	Homo sapiens	22-26
34023221-9	2021	Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19.	Oxygen	97-103	C-reactive protein	Homo sapiens	23-41
34023221-9	2021	Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19.	Oxygen	97-103	C-reactive protein	Homo sapiens	43-46
34054553-11	2021	However, inflammation-associated genes induced by TNF/IL17 were attenuated at low oxygen concentration.	Oxygen	82-88	tumor necrosis factor	Homo sapiens	50-53
34054553-12	2021	We detected substantial oxygen-dependent differences in gene expression in untreated as well as TNF/IL17 treated colonoids in all donors.	Oxygen	24-30	tumor necrosis factor	Homo sapiens	96-99
33987886-4	2021	The NO3 - produced by this reaction is chemically converted to N2 O, and continuous-flow isotope ratio mass spectrometry (CF-IRMS) is used to determine the oxygen isotopic compositions.	Oxygen	156-162	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
33886262-1	2021	In this work, a self-circulation oxygen-hydrogen peroxide-oxygen (O2-H2O2-O2) system with photogenerated electrons as fuel and highly active hemin monomers as operators was engineered for ultrasensitive cathode photoelectrochemical bioassay of microRNA-141 (miRNA-141) using a stacked sealed paper device.	Oxygen	33-39	microRNA 141	Homo sapiens	244-256
33544461-8	2021	Mechanistically, we found berberine improved cardiac mitochondrial biogenesis and activities, whereas silencing Klf4 decreased berberine-upregulated mitochondrial quality, ATP production and oxygen consumption.	Oxygen	191-197	Kruppel-like factor 4 (gut)	Mus musculus	112-116
33823141-5	2021	Mechanistically, exposure of senescent cells to low-oxygen conditions leads to AMPK activation and AMPK-mediated suppression of the mTOR-NF-kappaB signaling loop.	Oxygen	52-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
33886262-1	2021	In this work, a self-circulation oxygen-hydrogen peroxide-oxygen (O2-H2O2-O2) system with photogenerated electrons as fuel and highly active hemin monomers as operators was engineered for ultrasensitive cathode photoelectrochemical bioassay of microRNA-141 (miRNA-141) using a stacked sealed paper device.	Oxygen	58-64	microRNA 141	Homo sapiens	244-256
33890760-2	2021	Here, we report on augmenting the O2-evolving strategy based on a biomimetic, catalytic nanovehicle (named as N/P@MCC), constructed by the catalase-immobilized hollow mesoporous nanospheres by enveloping a cancer cell membrane (CCM), which acts as an efficient nanocontainer to accommodate nitrogen-doped graphene quantum dots (N-GQDs) and protoporphyrin IX (PpIX).	Oxygen	34-36	catalase	Homo sapiens	139-147
33890760-5	2021	Leveraging the intrinsic catalytic features of catalase, such N/P@MCC nanovehicles effectively scavenged the excessive H2O2 to sustainably evolve oxygen for a synchronous O2 self-supply and hypoxia alleviation, with an additional benefit because the resulting O2 bubbles could function as an echo amplifier, leading to the sufficient echogenic reflectivity for ultrasound imaging.	Oxygen	146-152	catalase	Homo sapiens	47-55
33886262-1	2021	In this work, a self-circulation oxygen-hydrogen peroxide-oxygen (O2-H2O2-O2) system with photogenerated electrons as fuel and highly active hemin monomers as operators was engineered for ultrasensitive cathode photoelectrochemical bioassay of microRNA-141 (miRNA-141) using a stacked sealed paper device.	Oxygen	66-68	microRNA 141	Homo sapiens	244-256
33890760-5	2021	Leveraging the intrinsic catalytic features of catalase, such N/P@MCC nanovehicles effectively scavenged the excessive H2O2 to sustainably evolve oxygen for a synchronous O2 self-supply and hypoxia alleviation, with an additional benefit because the resulting O2 bubbles could function as an echo amplifier, leading to the sufficient echogenic reflectivity for ultrasound imaging.	Oxygen	121-123	catalase	Homo sapiens	47-55
33890760-5	2021	Leveraging the intrinsic catalytic features of catalase, such N/P@MCC nanovehicles effectively scavenged the excessive H2O2 to sustainably evolve oxygen for a synchronous O2 self-supply and hypoxia alleviation, with an additional benefit because the resulting O2 bubbles could function as an echo amplifier, leading to the sufficient echogenic reflectivity for ultrasound imaging.	Oxygen	171-173	catalase	Homo sapiens	47-55
33886262-1	2021	In this work, a self-circulation oxygen-hydrogen peroxide-oxygen (O2-H2O2-O2) system with photogenerated electrons as fuel and highly active hemin monomers as operators was engineered for ultrasensitive cathode photoelectrochemical bioassay of microRNA-141 (miRNA-141) using a stacked sealed paper device.	Oxygen	71-73	microRNA 141	Homo sapiens	244-256
33949206-0	2021	Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen induced lung injury.	Oxygen	90-96	sodium channel, nonvoltage-gated 1 beta	Mus musculus	56-62
33948984-3	2021	The surgical resection of a kidney tumor induces tissue ischemia and HIF-1alpha is an oxygen-sensitive transcription factor, which is known to be up-regulated during hypoxia.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
33953170-3	2021	Here, we demonstrate that Salmonella YB1, an engineered oxygen-sensitive strain, potently inhibits metastasis of a broad range of cancers.	Oxygen	56-62	Y-box binding protein 1	Homo sapiens	37-40
33545379-9	2021	Taken together, it can be deduced that Ngb has protective effects against arsenic-induced apoptosis by eliminating reactive oxygen species.	Oxygen	124-130	neuroglobin	Rattus norvegicus	39-42
33882668-5	2021	This Co(II)-OOSO3- exhibits several intriguing properties including ability to conduct both one-electron-transfer and oxygen-atom-transfer reactions with selected molecules, both nucleophilic and electrophilic in nature, and strongly pH-dependent reactivity.	Oxygen	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
33938317-4	2021	Hippocampal neurons were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to simulate cerebral ischemia-reperfusion injury in vitro, which led to significant increases in the expression of PHLDA1.	Oxygen	38-44	pleckstrin homology like domain family A member 1	Homo sapiens	202-208
32759964-8	2021	On contrary, overexpression of Mzb1 improved mitochondrial membrane potential, ATP levels and mitochondrial oxygen consumption rate (OCR), and inhibited apoptosis.	Oxygen	108-114	marginal zone B and B1 cell-specific protein 1	Mus musculus	31-35
33434657-0	2021	c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.	Oxygen	57-63	CASP8 and FADD like apoptosis regulator	Homo sapiens	0-6
33839624-2	2021	In this research, noninvasive Escherichia coli (E. Coli) is genetically modified through the plasmid transfection to afford E. Coli(p) with overexpressed human catalase for catalyzing H2O2 into O2 in the tumor site.	Oxygen	186-188	catalase	Homo sapiens	160-168
33545379-4	2021	In this study, we aimed to study the effects of Ngb knockdown in arsenite-treated rat neurons on levels of apoptosis markers and reactive oxygen species and serum Ngb levels of subjects from arsenic-endemic regions in China.	Oxygen	138-144	neuroglobin	Rattus norvegicus	48-51
33655768-11	2021	Switching from oxygen to hypoxia during CFTR-measurements, reduced CFTR activity (p=0.03).	Oxygen	15-21	CF transmembrane conductance regulator	Homo sapiens	40-44
33655768-11	2021	Switching from oxygen to hypoxia during CFTR-measurements, reduced CFTR activity (p=0.03).	Oxygen	15-21	CF transmembrane conductance regulator	Homo sapiens	67-71
33609419-10	2021	The tumor cells from MMTV-ErbB2/Leprdb/db transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.	Oxygen	136-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-31
33325610-0	2021	Butein induces cellular senescence through reactive oxygen species-mediated p53 activation in osteosarcoma U-2 OS cells.	Oxygen	52-58	tumor protein p53	Homo sapiens	76-79
33272734-2	2021	Hypoxia inducible factor-1 (HIF-1alpha) is a transcription factor which plays an important part in adapting lower oxygen condition.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
33675821-2	2021	In this study, we investigated the impact of low oxygen (hypoxia) on ex vivo myelo-erythroid differentiation of human cord blood derived CD34+ hematopoietic stem and progenitor cells.	Oxygen	49-55	CD34 molecule	Homo sapiens	137-141
33757863-8	2021	These findings reveal early life exposure to high levels of oxygen may suppresses fat accumulation and impair adipogenic differentiation upstream of PPARgamma signaling, thus potentially contributing to growth failure seen in people born preterm.	Oxygen	60-66	peroxisome proliferator activated receptor gamma	Homo sapiens	149-158
33713839-0	2021	Dual PPARgamma/alpha Agonist Oroxyloside Suppresses Cell Cycle Progression by Glycolipid Metabolism Switch-Mediated Increase of Reactive Oxygen Species Levels.	Oxygen	137-143	peroxisome proliferator activated receptor gamma	Homo sapiens	5-20
33932953-3	2021	LRRC8C knockdown inhibited TNFalpha-induced O2  - production, receptor endocytosis, NF-kappaB activation, and proliferation while LRRC8D knockdown enhanced NF-kappaB activation.	Oxygen	44-49	tumor necrosis factor	Homo sapiens	27-35
33636416-4	2021	OBJECTIVE: To explore the association between plasma ET-1 levels and maximal oxygen consumption (pVO2), and their changes over 24 weeks in HFpEF.	Oxygen	77-83	endothelin 1	Homo sapiens	53-57
33636416-14	2021	CONCLUSIONS: Plasma ET1 levels are significantly associated with lower exercise oxygen consumption both at baseline and longitudinally over 24 weeks.	Oxygen	80-86	endothelin 1	Homo sapiens	20-23
33226577-1	2021	Hypoxia-inducible factor-3alpha (HIF-3alpha), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia.	Oxygen	108-114	hypoxia inducible factor 3 subunit alpha	Homo sapiens	0-31
33226577-1	2021	Hypoxia-inducible factor-3alpha (HIF-3alpha), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia.	Oxygen	108-114	hypoxia inducible factor 3 subunit alpha	Homo sapiens	33-43
33835424-1	2021	Hypoxia-inducible factor1 (HIF1) plays a pivotal role in ensuring cells adapt to low-oxygen conditions.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-25
33835424-1	2021	Hypoxia-inducible factor1 (HIF1) plays a pivotal role in ensuring cells adapt to low-oxygen conditions.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-31
33835424-2	2021	Depletion of oxygen, a co-substrate during hydroxylation of prolyl (P402 and P564) residues of HIF1 , evades HIF1  ubiquitination and enables its dimerization with HIF1beta to mediate global transcriptional response to hypoxia.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-99
33835424-2	2021	Depletion of oxygen, a co-substrate during hydroxylation of prolyl (P402 and P564) residues of HIF1 , evades HIF1  ubiquitination and enables its dimerization with HIF1beta to mediate global transcriptional response to hypoxia.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-113
33835424-2	2021	Depletion of oxygen, a co-substrate during hydroxylation of prolyl (P402 and P564) residues of HIF1 , evades HIF1  ubiquitination and enables its dimerization with HIF1beta to mediate global transcriptional response to hypoxia.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-172
33932953-10	2021	ABSTRACT: Tumor necrosis factor-alpha (TNFalpha) activates NADPH Oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs), producing superoxide (O2  - ) required for subsequent signaling.	Oxygen	145-150	tumor necrosis factor	Homo sapiens	10-37
33932953-10	2021	ABSTRACT: Tumor necrosis factor-alpha (TNFalpha) activates NADPH Oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs), producing superoxide (O2  - ) required for subsequent signaling.	Oxygen	145-150	tumor necrosis factor	Homo sapiens	39-47
33760122-3	2021	Over the past two decades, biological studies of hypoxia and hypoxia-inducible factor-1alpha (HIF-1alpha) have notably improved understanding of oxygen homeostasis.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
33932953-14	2021	In VSMCs, LRRC8C knockdown (siRNA) recapitulated the effects of siLRRC8A, inhibiting TNFalpha-induced extracellular and endosomal O2  - production, receptor endocytosis, NF-kappaB activation, and proliferation.	Oxygen	130-135	tumor necrosis factor	Homo sapiens	85-93
33752971-2	2021	In the Ndufs4-/- mouse model of Leigh syndrome, continuously breathing 11% O2 (hypoxia) prevents neurodegeneration and leads to a dramatic extension (~5-fold) in lifespan.	Oxygen	75-77	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	7-13
33752971-5	2021	Compared to WT control mice, Ndufs4-/- mice breathing air have reduced brain O2 consumption as evidenced by an elevated partial pressure of O2 in IJV blood (PijvO2) despite a normal PO2 in arterial blood, and higher lactate/pyruvate (L/P) ratios in IJV plasma revealed by metabolic profiling.	Oxygen	77-79	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	29-35
33752971-5	2021	Compared to WT control mice, Ndufs4-/- mice breathing air have reduced brain O2 consumption as evidenced by an elevated partial pressure of O2 in IJV blood (PijvO2) despite a normal PO2 in arterial blood, and higher lactate/pyruvate (L/P) ratios in IJV plasma revealed by metabolic profiling.	Oxygen	140-142	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	29-35
33760122-3	2021	Over the past two decades, biological studies of hypoxia and hypoxia-inducible factor-1alpha (HIF-1alpha) have notably improved understanding of oxygen homeostasis.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-92
33760122-4	2021	HIF-1alpha is an oxygen-sensitive transcription factor that mediates adaptive metabolic responses to hypoxia and serves a pivotal role in MIRI.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
33411248-4	2021	Given its key role in governing the cellular antioxidant response, upregulation of Nrf2 has been suggested as a common therapeutic target in neuropsychiatric illnesses such as major depressive disorder, bipolar disorder and schizophrenia, which are associated with chronic oxidative and nitrosative stress, characterised by elevated levels of reactive oxygen species, nitric oxide and peroxynitrite.	Oxygen	352-358	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
33760170-0	2021	Acute glucose fluctuation promotes RAGE expression via reactive oxygen species-mediated NF-kappaB activation in rat podocytes.	Oxygen	64-70	advanced glycosylation end product-specific receptor	Rattus norvegicus	35-39
33964761-6	2021	In addition, the interactions between Pb(II) ions and the oxygen atoms in the hydroxyl groups and the sulfur atoms in the sulfhydryl groups, and the ion exchange in MMTNs-SH dominated the adsorption.	Oxygen	58-64	submaxillary gland androgen regulated protein 3B	Homo sapiens	38-44
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	epidermal growth factor receptor	Homo sapiens	113-117
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	epidermal growth factor receptor	Homo sapiens	120-124
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	vascular endothelial growth factor A	Homo sapiens	125-131
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	fms related receptor tyrosine kinase 1	Homo sapiens	132-139
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-208
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	vascular endothelial growth factor C	Homo sapiens	209-215
33838472-3	2021	Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2-) mediates sustained IKK phosphorylation, and induces downstream degradation of IkappaBalpha, leading to the nuclear localization and transcriptional activation of NF-kappaB.	Oxygen	103-106	superoxide dismutase 1	Homo sapiens	49-53
33838472-3	2021	Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2-) mediates sustained IKK phosphorylation, and induces downstream degradation of IkappaBalpha, leading to the nuclear localization and transcriptional activation of NF-kappaB.	Oxygen	103-106	NFKB inhibitor alpha	Homo sapiens	186-198
33838472-3	2021	Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2-) mediates sustained IKK phosphorylation, and induces downstream degradation of IkappaBalpha, leading to the nuclear localization and transcriptional activation of NF-kappaB.	Oxygen	103-106	nuclear factor kappa B subunit 1	Homo sapiens	270-279
33838472-7	2021	Given that NF-kappaB is a key player of chronic inflammation and carcinogenesis, our work unravels a novel synergistic node involving O2--driven redox milieu and deregulated PP2A as a potential therapeutic target.	Oxygen	134-136	nuclear factor kappa B subunit 1	Homo sapiens	11-20
33847489-2	2021	Since oxygen scarcity at the joints causes an imbalance of macrophages M1 and M2, herein, we designed a cyanobacteria micro-nanodevice that can be spatiotemporally controlled in vivo to continuously producing oxygen in the RA joints for the downregulation of the expression of HIF-1alpha, thereby reducing the amounts of M1 macrophages and inducing the polarization of M2 macrophages for chemically sensitized RA treatment.	Oxygen	209-215	hypoxia inducible factor 1 subunit alpha	Homo sapiens	277-287
33930202-16	2021	Our results showed that the inhibitory effect of mTOR inhibitor (rapamycin) on reactive oxygen species production during NLRP3 inflammasome activation could bring about behavioral alterations in anxiety and depression.	Oxygen	88-94	NLR family, pyrin domain containing 3	Rattus norvegicus	121-126
33913012-3	2021	METHODS: Insulin-producing cells (INS-1E) were maintained in control or amino acid restricted culture medium containing 1 x or 0.25 x of amino acids, respectively, for 48 h. RESULTS: Amino acid restricted group showed lower insulin secretion and insulin gene expression, reduced mitochondrial oxygen consumption rate and reactive oxygen species production.	Oxygen	293-299	insulin	Homo sapiens	9-16
33913012-3	2021	METHODS: Insulin-producing cells (INS-1E) were maintained in control or amino acid restricted culture medium containing 1 x or 0.25 x of amino acids, respectively, for 48 h. RESULTS: Amino acid restricted group showed lower insulin secretion and insulin gene expression, reduced mitochondrial oxygen consumption rate and reactive oxygen species production.	Oxygen	330-336	insulin	Homo sapiens	9-16
33896415-1	2021	The Hypoxia-Inducible Factor-1 (HIF-1) is a dimeric protein complex that plays a significant role in responding to low oxygen or hypoxia concentrations.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
33909926-7	2021	These observations suggested that ER stress and the generation of reactive oxygen species are essential for the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA in keratinocytes.	Oxygen	75-81	interferon gamma	Homo sapiens	140-149
33899241-7	2022	MCH neuron-ablated mice exhibited reduced body weight, increased oxygen consumption, and increased BAT activity, which improved locomotor activity-independent energy expenditure.	Oxygen	65-71	pro-melanin concentrating hormone	Homo sapiens	0-3
33754689-4	2021	When a submonolayer of Pt is deposited on the 6 nm nanocubes, the resulting Pd@a-Pd-P@PtSML core-shell catalyst can deliver a mass activity as high as 4.08 A/mgPt and 1.37 A/mgPd+Pt toward the oxygen reduction reaction at 0.9 V vs the reversible hydrogen electrode and undergoes 50 000 potential cycles with only ~9% activity loss and negligible structural deformation.	Oxygen	193-199	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	81-85
33896415-1	2021	The Hypoxia-Inducible Factor-1 (HIF-1) is a dimeric protein complex that plays a significant role in responding to low oxygen or hypoxia concentrations.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
33895725-8	2021	With dox, and in response to allergen, TAZ shRNA+/+ FLMCs displayed a 25% reduction in oxygen consumption and a significant 31% reduction in mast cell degranulation compared with dox-treated WT FLMCs.	Oxygen	87-93	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	39-42
33923136-6	2021	CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals).	Oxygen	196-202	superoxide dismutase 1	Homo sapiens	142-145
33923136-6	2021	CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals).	Oxygen	283-289	superoxide dismutase 1	Homo sapiens	142-145
33895966-0	2021	The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.	Oxygen	46-52	adenylate cyclase activating polypeptide 1	Mus musculus	37-42
33922401-1	2021	A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting That Central Effects Can Be Avoided.	Oxygen	50-56	cannabinoid receptor 1	Homo sapiens	13-17
33922069-8	2021	Down-regulation of SlGRAS10 significantly enhanced the expressions of catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) to reduce the effects of reactive oxygen species (ROS) such as O2- and H2O2.	Oxygen	198-201	GRAS10 protein	Solanum lycopersicum	19-27
33893167-0	2021	S1P2-Galpha12 signaling inhibits astrocytic glutamate uptake and mitochondrial oxygen consumption.	Oxygen	79-85	guanine nucleotide binding protein, alpha 12	Mus musculus	5-13
33515534-2	2021	Hypoxia-inducible factor 1 alpha (HIF-1alpha) is the key mediator of oxygen homoeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
33967734-12	2021	High angiotensin II levels might even aggravate neurodegeneration, activating the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, which leads to increased reactive oxygen species production.	Oxygen	185-191	angiotensinogen	Homo sapiens	5-19
33652166-0	2021	DT-Diaphorase Triggered Theranostic Nanoparticles Induce the Self-burst of Reactive Oxygen Species for Tumor Diagnosis and Treatment.	Oxygen	84-90	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
33878266-0	2021	Femtomolar Detection of Thrombin in Serum and Cerebrospinal Fluid via Direct Electrocatalysis of Oxygen Reduction by the Covalent G4-Hemin-Aptamer Complex.	Oxygen	97-103	coagulation factor II, thrombin	Homo sapiens	24-32
33878266-3	2021	Here, femtomolar levels of thrombin in serum and an artificial cerebrospinal fluid (CSF) were detected by the indicator-free electrochemical methodology exploiting the O2 reduction reaction directly, with no electron transfer mediators, electrocatalyzed by the covalent G4-hemin DNAzyme complex naturally self-assembling upon thrombin binding to the hemin-modified 29-mer DNA aptamer sequence tethered to gold via an alkanethiol linker.	Oxygen	168-170	coagulation factor II, thrombin	Homo sapiens	27-35
33878266-3	2021	Here, femtomolar levels of thrombin in serum and an artificial cerebrospinal fluid (CSF) were detected by the indicator-free electrochemical methodology exploiting the O2 reduction reaction directly, with no electron transfer mediators, electrocatalyzed by the covalent G4-hemin DNAzyme complex naturally self-assembling upon thrombin binding to the hemin-modified 29-mer DNA aptamer sequence tethered to gold via an alkanethiol linker.	Oxygen	168-170	coagulation factor II, thrombin	Homo sapiens	326-334
34041450-5	2021	Further study showed Nrf2 regulated reactive-oxygen-species-mediated Hippo-yes-associated protein (YAP) signaling, which in turn modulated the NLRP3 inflammasome activation.	Oxygen	45-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
33592181-1	2021	Human cytochrome P450 enzymes (CYPs or P450s) are known to be reduced by their electron transfer partners in the absence of substrate and in turn to reduce other acceptor molecules such as molecular oxygen, thereby creating superoxide anions (O2- ).	Oxygen	199-205	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-21
33515534-2	2021	Hypoxia-inducible factor 1 alpha (HIF-1alpha) is the key mediator of oxygen homoeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
33592181-1	2021	Human cytochrome P450 enzymes (CYPs or P450s) are known to be reduced by their electron transfer partners in the absence of substrate and in turn to reduce other acceptor molecules such as molecular oxygen, thereby creating superoxide anions (O2- ).	Oxygen	243-246	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-21
33596416-6	2021	Compared to the controls, sinomenine showed a protective effect on TNF-alpha-induced apoptosis on DRG cells in a dose-dependent manner, with an increase of cell viability and a decrease of reactive oxygen species level as well as LDH release.	Oxygen	198-204	tumor necrosis factor	Rattus norvegicus	67-76
33592181-6	2021	Cells expressing other CYPs had an even stronger effect, with those expressing CYP2B6, CYP5A1, CYP2A13, CYP51A1, or CYP1A2, respectively, being the strongest producers of O2- .	Oxygen	171-174	thromboxane A synthase 1	Homo sapiens	87-93
33592181-6	2021	Cells expressing other CYPs had an even stronger effect, with those expressing CYP2B6, CYP5A1, CYP2A13, CYP51A1, or CYP1A2, respectively, being the strongest producers of O2- .	Oxygen	171-174	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	104-111
33921064-5	2021	Using a nitroimidazole-indocyanine conjugate, we show that HIF-1 aberrant expression and transcription activity is oxygen independent, establishing the phenomenon of pseudohypoxia in MDS BM.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-64
33936006-1	2021	Cytochrome P450 enzymes, or P450s, are haem monooxygenases renowned for their ability to insert one atom from molecular oxygen into an exceptionally broad range of substrates while reducing the other atom to water.	Oxygen	48-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
33851769-0	2021	Circular RNA circZNF292 regulates H2 O2 -induced injury in human lens epithelial HLE-B3 cells depending on the regulation of the miR-222-3p/E2F3 axis.	Oxygen	37-39	E2F transcription factor 3	Homo sapiens	140-144
33919770-4	2021	This report aims to add to this field of ASC through exploring how the perception of an experienced Sangoma (traditional South African healer) entering a trance process correlates to blood-oxygen-level-dependent (BOLD) signal modulation with auditory stimuli.	Oxygen	189-195	PYD and CARD domain containing	Homo sapiens	41-44
33851896-5	2021	In the cross-sectional analysis, anti-Ro52/TRIM21 was independently associated with PAH [odds ratio 1.75, 95% confidence interval (CI) 1.05-2.90], but not ILD or other surrogate measures of pulmonary involvement such as average patient oxygen saturation.	Oxygen	236-242	tripartite motif containing 21	Homo sapiens	38-42
33851896-5	2021	In the cross-sectional analysis, anti-Ro52/TRIM21 was independently associated with PAH [odds ratio 1.75, 95% confidence interval (CI) 1.05-2.90], but not ILD or other surrogate measures of pulmonary involvement such as average patient oxygen saturation.	Oxygen	236-242	tripartite motif containing 21	Homo sapiens	43-49
33607387-5	2021	Electron spin resonance (ESR) spectrometry and UV-Vis spectrophotometer proved that VL can activate PM to generate  O2- and Mn (III) reactive species.	Oxygen	116-118	modulator of VRAC current 1	Homo sapiens	84-86
33847405-7	2022	Notably, the percent of pulmonary effector CD8+ GrB+ IFNgamma+ T cells at day 10 post-infection correlated positively with total CD8+ basal extracellular acidification rate and basal oxygen consumption rate.	Oxygen	183-189	interferon gamma	Mus musculus	53-61
33838689-5	2021	Both PARP1 and GAPDH were found involved in the hub network of protein-protein interaction (PPI) of potential targets and were found to take part in many bioprocesses, including responding to the regulation of reactive oxygen species (ROS) metabolic process, apoptotic signaling pathway, and response to oxygen levels through enrichment analysis.	Oxygen	219-225	poly(ADP-ribose) polymerase 1	Homo sapiens	5-10
33924614-3	2021	Expression of osterix (OSX) and vascular endothelial growth factor A (VEGFA) was significantly enhanced in the 3D scaffold in all oxygen environments.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	32-68
33924614-3	2021	Expression of osterix (OSX) and vascular endothelial growth factor A (VEGFA) was significantly enhanced in the 3D scaffold in all oxygen environments.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	70-75
33920158-4	2021	Both RCC and ADPKD result in hypoxia, where HIF-alpha signaling is activated in response to oxygen deprivation.	Oxygen	92-98	similar	Drosophila melanogaster	44-53
33838689-5	2021	Both PARP1 and GAPDH were found involved in the hub network of protein-protein interaction (PPI) of potential targets and were found to take part in many bioprocesses, including responding to the regulation of reactive oxygen species (ROS) metabolic process, apoptotic signaling pathway, and response to oxygen levels through enrichment analysis.	Oxygen	219-225	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	15-20
33836774-4	2021	It promotes gene transcription of pro-angiogenic proteins such as HIF-1alpha during periods of oxygen scarcity (hypoxia) to enhance tumor growth and angiogenesis stimulation.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
33918767-5	2021	AGE can, in turn, promote CKD progression and CKD-related complications by increasing reactive oxygen species generation, inducing inflammation, and promoting fibrosis.	Oxygen	95-101	renin binding protein	Homo sapiens	0-3
33948568-3	2021	This study presents a stringent hypoxia-sensing CAR T cell system that achieves selective expression of a pan-ErbB-targeted CAR within a solid tumor, a microenvironment characterized by inadequate oxygen supply.	Oxygen	197-203	nuclear receptor subfamily 1, group I, member 3	Mus musculus	48-51
33948568-5	2021	This dynamic on/off oxygen-sensing safety switch has the potential to facilitate unlimited expansion of the CAR T cell target repertoire for treating solid malignancies.	Oxygen	20-26	nuclear receptor subfamily 1, group I, member 3	Mus musculus	108-111
33854312-5	2021	Due to the good protection of enzyme, the catalase within the nanoplatform efficiently produced the mount of O2 through decomposing the hydrogen peroxide in tumor tissues, which remarkably alleviated tumor hypoxia.	Oxygen	109-111	catalase	Homo sapiens	42-50
33833221-7	2021	Mutant KRAS increased the production of reactive oxygen species, an inhibitor of prolyl hydroxylase activity which decreases HIF-1alpha hydroxylation, leading to enhanced HIF-1alpha stabilization.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-135
33833221-7	2021	Mutant KRAS increased the production of reactive oxygen species, an inhibitor of prolyl hydroxylase activity which decreases HIF-1alpha hydroxylation, leading to enhanced HIF-1alpha stabilization.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
33916826-7	2021	Cytochrome c oxidase (COX) activity analyzed with purified Cytc variants showed reduced oxygen consumption with acetylmimetic Cytc compared to the non-acetylated Cytc (WT), supporting the Warburg effect.	Oxygen	88-94	cytochrome c, somatic	Homo sapiens	59-63
33539865-13	2021	The findings indicate that the rate oxygen is supplied by the retinal circulation is decreased and the reduction in oxygen extracted for metabolism is related to retinal cell layer thinning in rd1 mice.	Oxygen	36-42	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	193-196
33813735-2	2021	HIF-1 is a key mediator in both regulatory and pathogenic immune responses because ongoing inflammation in localized tissues causes increased oxygen consumption and consequent hypoxia within the inflammatory lesions.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
33296287-9	2021	The dynamic interplay between the core and regu-latory proteins modulates MCU channel activity after sensing local changes in [Ca2+]i, reactive oxygen species, and other environmental factors.	Oxygen	144-150	mitochondrial calcium uniporter	Homo sapiens	74-77
32948369-8	2021	HLA-DRB1*01:02 was also significantly associated with FEV1 (p=0.04) and oxygen saturation (p=0.02), and the FEV1/FVC ratio was higher in HLA-DRB1*15:01-positive patients (p=9x10-3).	Oxygen	72-78	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
33547161-7	2021	ELOVL5 depletion markedly altered mitochondrial morphology and function, leading to excess generation of reactive oxygen species and resulting in suppression of prostate cancer cell proliferation, 3D growth, and in vivo tumor growth and metastasis.	Oxygen	114-120	ELOVL fatty acid elongase 5	Homo sapiens	0-6
33460433-9	2021	Adcyap1  MBHKO mice exhibited decreased oxygen consumption (VO2), without changes in activity.	Oxygen	40-46	adenylate cyclase activating polypeptide 1	Mus musculus	0-7
33423553-8	2021	Mechanistically, sirtuin-3 deficiency induced retinal pigment epithelial cell dysfunction by the overproduction of mitochondrial reactive oxygen species.	Oxygen	138-144	sirtuin 3	Homo sapiens	17-26
33423553-9	2021	These results suggest that sirtuin-3 deficiency mediates the migration of retinal pigment epithelial cells, at least partially by increasing mitochondrial oxidative stress, and shed light on the importance of sirtuin-3 and mitochondrial reactive oxygen species as potential targets in diabetic retinopathy therapy.	Oxygen	246-252	sirtuin 3	Homo sapiens	27-36
33813735-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric (HIF-1alpha/ HIF-1beta) transcription factor in which the oxygen-sensitive HIF-1alpha subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
33813735-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric (HIF-1alpha/ HIF-1beta) transcription factor in which the oxygen-sensitive HIF-1alpha subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
33813735-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric (HIF-1alpha/ HIF-1beta) transcription factor in which the oxygen-sensitive HIF-1alpha subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
33813735-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric (HIF-1alpha/ HIF-1beta) transcription factor in which the oxygen-sensitive HIF-1alpha subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-76
33813735-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric (HIF-1alpha/ HIF-1beta) transcription factor in which the oxygen-sensitive HIF-1alpha subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
33609534-3	2021	Here, we showed a significant increase of GSDMD after exposure to high oxygen.	Oxygen	71-77	gasdermin D	Rattus norvegicus	42-47
33539865-13	2021	The findings indicate that the rate oxygen is supplied by the retinal circulation is decreased and the reduction in oxygen extracted for metabolism is related to retinal cell layer thinning in rd1 mice.	Oxygen	116-122	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	193-196
33611811-2	2021	As a regulator of ROS, cytoglobin (CYGB) plays an important role in oxygen homeostasis and acts as a tumour suppressor.	Oxygen	68-74	cytoglobin	Homo sapiens	23-33
33596456-6	2021	Both O2 consumption processes release ROS triggering the antioxidant system activation as we observed increased SOD and catalase activities and a decreased GSH/GSSG ratio.	Oxygen	5-7	catalase	Mus musculus	120-128
32557804-12	2021	Consistently, either LXRalpha activation or the let-7a/miR-34a transfection lowered mitochondrial oxygen consumption rate and mitochondrial transmembrane potential and increased fat levels.	Oxygen	98-104	microRNA 34a	Mus musculus	55-62
33660415-4	2021	Moreover, immunohistochemical staining results showed that TNF-alpha-induced brain dysfunction was caused by necroptosis and microglial activation, which could be attenuated by ketamine pre-treatment inhibiting reactive oxygen species production and mixed lineage kinase domain-like phosphorylation in hippocampal neurons.	Oxygen	220-226	tumor necrosis factor	Mus musculus	59-68
32613311-8	2021	Moreover, improved CPP was correlated with exercise intensity and peak oxygen uptake, two most important indicators of cardiopulmonary exercise capacities.	Oxygen	71-77	arginine vasopressin	Homo sapiens	19-22
33611811-2	2021	As a regulator of ROS, cytoglobin (CYGB) plays an important role in oxygen homeostasis and acts as a tumour suppressor.	Oxygen	68-74	cytoglobin	Homo sapiens	35-39
33246655-4	2021	Importantly, the dopant of P element can enrich oxygen vacancies on the surface of CoCH nanowire, thus increase the effective active sites and enhance the electrocatalytic performance.	Oxygen	48-54	cochlin	Homo sapiens	83-87
33611811-4	2021	Here, we show that CYGB overexpression increased ROS accumulation and disrupted mitochondrial function as determined by the oxygen consumption rate and membrane potential.	Oxygen	124-130	cytoglobin	Homo sapiens	19-23
33199226-9	2021	CONCLUSIONS: The decreased SOD activity and increased MDA content in our research prove a redox imbalance and high reactive oxygen species levels in flaps, indicating that tissues experience ischemia-reperfusion injury during microsurgical reconstruction.	Oxygen	124-130	superoxide dismutase 1	Homo sapiens	27-30
33105385-3	2021	Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, increases blood flow and improves O2 consumption, although the exact mechanisms in CF have yet to be elucidated.	Oxygen	91-93	phosphodiesterase 5A	Homo sapiens	40-44
34012567-7	2021	Results: The amounts of elastin, muscle, and collagen and the protein levels of ET-1, HIF-1alpha, Rock-1, and MMP-2, increased significantly with decreased oxygen saturation in the perfusion circuit.	Oxygen	156-162	endothelin 1	Homo sapiens	80-84
33958959-3	2021	It is known that cytoglobin (CYGB) has a function in O2 distribution.	Oxygen	53-55	cytoglobin	Homo sapiens	17-27
33784834-1	2021	Modest modulation of oxygen intake, either by inducing mild intermittent hypoxia or hyperoxia appears to induce modest rejuvenative changes in mammals in part by activating key regulator Hypoxia Induced Factor 1a (HIF-1a).	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-220
33958959-3	2021	It is known that cytoglobin (CYGB) has a function in O2 distribution.	Oxygen	53-55	cytoglobin	Homo sapiens	29-33
33548859-7	2021	The uncoupling of eNOS triggers a switch of its activity from a NO-producing enzyme to a NADPH oxidase-like system generating O2 -, thereby potentiating ROS production and oxidative stress.	Oxygen	126-130	nitric oxide synthase 3	Homo sapiens	18-22
33537810-6	2021	When the vicious cycle is established, the low oxygen tension activates the expression of HIF-1alpha, which subsequently enters into the hypoxia-induced HIF pathways.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
33784834-3	2021	Hyperbaric oxygen induces HIF-1a by the hyperoxic-hypoxic paradox which results from an overinduction of protective factors under intermittent hyperoxic conditions leading to a state somewhat similar to that induced by hypoxia.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-32
33842469-4	2021	The activity of HIF-1 is dictated primarily by its alpha subunit (HIF-1alpha), whose level and/or activity are largely regulated by an oxygen-dependent and ubiquitin/proteasome-mediated process.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
33848794-4	2021	Remarkably, when cultured at a physiological oxygen tension of 1% O2, a 10-fold reduction in CD45+ hematopoietic cells associated with a concomitant increase in PDGFRalpha+ stromal cells occur.	Oxygen	45-51	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	161-171
33848794-4	2021	Remarkably, when cultured at a physiological oxygen tension of 1% O2, a 10-fold reduction in CD45+ hematopoietic cells associated with a concomitant increase in PDGFRalpha+ stromal cells occur.	Oxygen	66-68	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	161-171
33186656-4	2021	We report deficiency of the post-translational modification enzyme protein arginine N-methyltransferase 6 (PRMT6) in HCC to promote the induction of autophagy under oxygen/nutrient-derived and sorafenib drug-induced stress conditions.	Oxygen	165-171	protein arginine methyltransferase 6	Homo sapiens	67-105
33186656-4	2021	We report deficiency of the post-translational modification enzyme protein arginine N-methyltransferase 6 (PRMT6) in HCC to promote the induction of autophagy under oxygen/nutrient-derived and sorafenib drug-induced stress conditions.	Oxygen	165-171	protein arginine methyltransferase 6	Homo sapiens	107-112
33450350-1	2021	BACKGROUND: Leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1A) are involved in the pathogenesis of multiple sclerosis (MS) by affecting the inflammatory response and reactive oxygen species production.	Oxygen	243-249	PPARG coactivator 1 alpha	Homo sapiens	53-122
33450350-1	2021	BACKGROUND: Leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1A) are involved in the pathogenesis of multiple sclerosis (MS) by affecting the inflammatory response and reactive oxygen species production.	Oxygen	243-249	PPARG coactivator 1 alpha	Homo sapiens	124-129
33782423-7	2021	STAT3 but not mTORC1 activation was essential for HIF-1alpha accumulation, glycolysis, and oxygen consumption.	Oxygen	91-97	signal transducer and activator of transcription 3	Homo sapiens	0-5
33789854-11	2021	43.6% were directly admitted to hospital care.CART analysis identified the variables oxygen saturation (<95%), dyspnoea and history of cardiovascular (CV) disease to distinguish between high and low-risk groups.	Oxygen	85-91	CART prepropeptide	Homo sapiens	46-50
33733739-4	2021	Here, we propose an alternative enzymatic method that uses O2 bubbles generated by endogenous catalase enzymes in order to liquefy respiratory samples.	Oxygen	59-61	catalase	Homo sapiens	94-102
33785647-9	2021	Ultrastructural, transcriptomic, and functional analyses revealed an alternative metabolic response to chemotherapy in beta3-expressing cells characterized by enhanced oxygen consumption, reactive oxygen species generation, and protein production.	Oxygen	168-174	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	119-124
33785647-9	2021	Ultrastructural, transcriptomic, and functional analyses revealed an alternative metabolic response to chemotherapy in beta3-expressing cells characterized by enhanced oxygen consumption, reactive oxygen species generation, and protein production.	Oxygen	197-203	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	119-124
33785835-0	2021	In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway.	Oxygen	3-9	protein disulfide isomerase family A member 3	Homo sapiens	31-36
33785835-0	2021	In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway.	Oxygen	3-9	AKT serine/threonine kinase 1	Homo sapiens	112-115
33785835-4	2021	We observed a severe growth inhibition when ERp57 was knocked down in hypoxia (1% O2) as a consequence of downregulated c-Myc, PLK1, PDPK1 (PDK1) and AKT (PKB).	Oxygen	82-84	protein disulfide isomerase family A member 3	Homo sapiens	44-49
33785835-5	2021	Further, irradiation experiments revealed also a radiosensitizing effect of ERp57 depletion under oxygen deprivation.	Oxygen	98-104	protein disulfide isomerase family A member 3	Homo sapiens	76-81
33790636-10	2021	Oxygen saturation at presentation had a negative correlation with D-Dimer, age, and C reactive protein.	Oxygen	0-6	C-reactive protein	Homo sapiens	84-102
33842469-4	2021	The activity of HIF-1 is dictated primarily by its alpha subunit (HIF-1alpha), whose level and/or activity are largely regulated by an oxygen-dependent and ubiquitin/proteasome-mediated process.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
33550096-1	2021	The hypoxia-inducible factor (HIF-1alpha) functions as a master regulator of oxygen homeostasis.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
33865748-3	2021	Hypoxia-inducible factors (HIFs) are transcription factors that activate multiple oxygen-sensitive genes, including those encoding for vascular endothelial growth factor (VEGF).	Oxygen	82-88	vascular endothelial growth factor A	Homo sapiens	171-175
33625212-6	2021	Subsequently, the classic inducible nitric oxide synthase (iNOS) pathway aroused by immune response was revolutionarily utilized to oxidize the l-arginine substrates for NO production, the process for which could also be promoted by the high reactive oxygen species level generated by chemo-PTT.	Oxygen	251-257	nitric oxide synthase 2	Homo sapiens	26-57
33625212-6	2021	Subsequently, the classic inducible nitric oxide synthase (iNOS) pathway aroused by immune response was revolutionarily utilized to oxidize the l-arginine substrates for NO production, the process for which could also be promoted by the high reactive oxygen species level generated by chemo-PTT.	Oxygen	251-257	nitric oxide synthase 2	Homo sapiens	59-63
33550096-2	2021	Oxygen-dependent hydroxylation of HIF-1alpha is tightly regulated by prolyl hydroxylase domain containing proteins (PHD1, PHD2, and PHD3).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
33550096-2	2021	Oxygen-dependent hydroxylation of HIF-1alpha is tightly regulated by prolyl hydroxylase domain containing proteins (PHD1, PHD2, and PHD3).	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	122-126
33729121-0	2021	The Nrf2 inhibitor brusatol has a protective role in a rat model of oxygen-induced retinopathy of prematurity.	Oxygen	68-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
33738852-5	2021	Further investigations revealed that glycine decreased NaF-induced intracellular reactive oxygen species production, DNA fragment accumulation, and the apoptosis incidence in the porcine testicular Sertoli cell line; in addition, glycine improved mitochondrial function and ATP production.	Oxygen	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33605969-3	2021	Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.	Oxygen	20-26	caspase 3	Homo sapiens	97-106
33705641-0	2021	Hyperbaric oxygen therapy affects insulin sensitivity/resistance by increasing adiponectin, resistin, and plasminogen activator inhibitor-I in rats.	Oxygen	11-17	resistin	Rattus norvegicus	92-100
33790802-5	2021	Moderate hyperoxia (50% O2) increased fASM CaSR expression.	Oxygen	24-26	calcium sensing receptor	Homo sapiens	43-47
33691909-0	2021	Nrf2 induces Ucp1 expression in adipocytes in response to beta3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice.	Oxygen	92-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
33682133-6	2021	Glucose starvation also induced the accumulation of reactive oxygen species in renal cells, which was involved in the activation of the ERK1/2 cascade and the induction of autophagy in renal cells.	Oxygen	61-67	mitogen-activated protein kinase 3	Homo sapiens	136-142
33683823-6	2021	We found that lower oxygen and glucose concentrations enhance the expression of mesodermal (Brachyury, KIF1A) and ectodermal (Nestin, beta-Tubulin) markers.	Oxygen	20-26	nestin	Homo sapiens	126-132
33460615-0	2021	Gliclazide alters macrophages polarization state in diabetic atherosclerosis in vitro via blocking AGE-RAGE/TLR4-reactive oxygen species-activated NF-kbeta nexus.	Oxygen	122-128	toll-like receptor 4	Mus musculus	108-112
33684901-0	2021	A porous heterostructure catalyst for oxygen evolution: synergy between IrP2nanocrystals and ultrathin P,N-codoped carbon nanosheets.	Oxygen	38-44	iron responsive element binding protein 2	Homo sapiens	72-76
33684901-6	2021	DFT calculations reveal that the synergistic effects derived from the IrP2/PNC interface, which can effectively tune the activation barriers towards facilitating the oxygen evolution process.	Oxygen	166-172	iron responsive element binding protein 2	Homo sapiens	70-74
33746945-3	2021	Our results indicated that IL-6 levels were closely related to age, sex, body temperature, oxygen saturation (SpO2) of blood, and underlying diseases.	Oxygen	91-97	interleukin 6	Homo sapiens	27-31
33470770-0	2021	Mild hypothermia protects rat cortical neurons against oxygen-glucose deprivation/reoxygenation injury via the PI3K/Akt pathway.	Oxygen	55-61	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
33754023-14	2021	Activating PPARalpha with WY14643 in primarily cultured Rap1-/- cardiomyocytes restored maximal oxygen consumption rates.	Oxygen	96-102	peroxisome proliferator activated receptor alpha	Mus musculus	11-20
33746978-0	2021	Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture.	Oxygen	107-113	Dcr3	Mus musculus	0-16
32335773-0	2021	Knockdown of TRIM22 Relieves Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Inflammation Through Inhibition of NF-kappaB/NLRP3 Axis.	Oxygen	29-35	NLR family pyrin domain containing 3	Homo sapiens	137-142
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-182
33001175-9	2021	CONCLUSION: Systemic vascular distensibility, alpha is associated with impaired systemic oxygen extraction and decreased aerobic capacity in patients with CTD without cardiopulmonary disease.	Oxygen	89-95	CTD	Homo sapiens	155-158
33850902-4	2021	Methods: LX-2 cells/NF-kappaB-silenced LX-2 cells were exposed to hypoxic conditions (1% O2) to activate HSCs in vitro.	Oxygen	89-91	nuclear factor kappa B subunit 1	Homo sapiens	20-29
33471265-0	2021	Effect of Nrf2 signaling pathway on the improvement of intestinal epithelial barrier dysfunction by hyperbaric oxygen treatment after spinal cord injury.	Oxygen	111-117	NFE2 like bZIP transcription factor 2	Rattus norvegicus	10-14
32898935-6	2021	HIF-1alpha stabilization was detected in 4-NB treated cells, possibly due to the contribution of both reduction of intracellular oxygen tension and ROS overproduction.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
33089460-6	2021	Furthermore, according to the analysis of adsorption interaction and the electrostatic attraction between Pb(II) and oxygen-containing functional groups on HA/WV are the dominant mechanisms responsible for Pb(II) sorption.	Oxygen	117-123	submaxillary gland androgen regulated protein 3B	Homo sapiens	206-212
33089460-7	2021	The wood vinegar liquid can improve the oxygen-containing group in HA/WV, which can enhance the complexation of remediation materials and Pb(II) ion.	Oxygen	40-46	submaxillary gland androgen regulated protein 3B	Homo sapiens	138-144
33068293-7	2021	After 72 hours, L and CRP had improved in the HFNC oxygen therapy group compared with the COT group, but the differences in WBC and PCT were not statistically significant.	Oxygen	51-57	C-reactive protein	Homo sapiens	22-25
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier organic anion transporter family member 4A1	Homo sapiens	149-156
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier family 6 member 4	Homo sapiens	223-227
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	ATP binding cassette subfamily C member 1	Homo sapiens	239-243
32438524-10	2021	PCBP1-deleted hepatocytes exhibited increased labile iron and production of reactive oxygen species, were hypersensitive to iron and prooxidants, and accumulated oxidatively-damaged lipids due to the reactivity of unchaperoned iron.	Oxygen	85-91	poly(rC) binding protein 1	Mus musculus	0-5
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Oxygen	82-84	albumin	Homo sapiens	35-42
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Oxygen	82-84	tumor associated calcium signal transducer 2	Homo sapiens	108-115
32438524-11	2021	CONCLUSIONS: Unchaperoned iron in PCBP1-deleted mouse hepatocytes leads to production of reactive oxygen species, resulting in lipid peroxidation and steatosis in the absence of iron overload.	Oxygen	98-104	poly(rC) binding protein 1	Mus musculus	34-39
33646507-2	2021	Hence, the need for a rapid and simple tool to support clinical decisions, such as the ROX index (Respiratory rate - OXygenation), defined as the ratio of peripheral oxygen saturation and fraction of inspired oxygen, to respiratory rate.	Oxygen	166-172	MAX network transcriptional repressor	Homo sapiens	87-90
33646507-2	2021	Hence, the need for a rapid and simple tool to support clinical decisions, such as the ROX index (Respiratory rate - OXygenation), defined as the ratio of peripheral oxygen saturation and fraction of inspired oxygen, to respiratory rate.	Oxygen	209-215	MAX network transcriptional repressor	Homo sapiens	87-90
33569852-2	2021	We describe here the formation and collision-induced dissociation (CID) of [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Oxygen	109-113	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
32716106-6	2021	E2 -induced M2 polarization occurred due to the increased expression of heme oxygenase-1 (HO-1) in macrophages, leading to decreased reactive oxygen species levels.	Oxygen	77-83	heme oxygenase 1	Mus musculus	90-94
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Oxygen	149-151	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Oxygen	149-151	NBL1, DAN family BMP antagonist	Homo sapiens	200-203
33569852-5	2021	DFT calculations also suggest that H2 O adducts to products such as [UO2 (O)(NO3 )]- spontaneously rearrange to create dihydroxides and that addition of O2 is favored over addition of H2 O to formally U(V) species.	Oxygen	70-72	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
33306634-11	2021	CONCLUSION: According to the results of this study, RNT with Lu-PSMA and Lu-DOTATATE may induce oxidative stress via the generation of free radicals and reactive oxygen species.	Oxygen	162-168	folate hydrolase 1	Homo sapiens	64-68
33508434-4	2021	The sirtuin family member sirtuin-3 (SIRT3) is involved in several key biological processes, including ATP production, catabolism, and reactive oxygen species detoxification.	Oxygen	144-150	sirtuin 3	Homo sapiens	26-35
32772808-5	2021	Compared with untransformed plants, the atpA-overexpressing tobacco showed an increased resistance to B. cinerea, characterized by reduced disease incidence, defense-associated hypersensitive response (HR)-like reactions, balanced reactive oxygen species, alleviated damage to chloroplast ultra-structure of leaf cell, elevated levels of ATP content and cpATPase activity, enhanced expression of carbon metabolism-, photosynthesis-, and defense-related genes.	Oxygen	240-246	ATP synthase CF1 alpha chain	Nicotiana tabacum	40-44
33508434-4	2021	The sirtuin family member sirtuin-3 (SIRT3) is involved in several key biological processes, including ATP production, catabolism, and reactive oxygen species detoxification.	Oxygen	144-150	sirtuin 3	Homo sapiens	37-42
33647056-5	2021	The iTRAQ proteomic analysis revealed that a cluster of glycolytic enzymes including malate dehydrogenase, cytoplasmic, L-lactate dehydrogenase, phosphoglycerate mutase and pyruvate kinase, and another cluster of proteins involved in oxygen transport and binding (myoglobin) and hemoglobin complex (including Globin A1 and hemoglobin subunit alpha) were decreased during the postmortem storage.	Oxygen	234-240	malic enzyme 2	Homo sapiens	85-105
33464716-4	2021	FePc/HNCSs simultaneously exhibit peroxidase (POD)- and catalase (CAT)-like activities, which not only can convert endogenous hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals ( OH) for catalytic therapy, but also decompose H2 O2 to oxygen (O2 ) to enhance O2 -dependent PDT.	Oxygen	246-252	catalase	Homo sapiens	66-69
33464716-4	2021	FePc/HNCSs simultaneously exhibit peroxidase (POD)- and catalase (CAT)-like activities, which not only can convert endogenous hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals ( OH) for catalytic therapy, but also decompose H2 O2 to oxygen (O2 ) to enhance O2 -dependent PDT.	Oxygen	148-150	catalase	Homo sapiens	66-69
33464716-4	2021	FePc/HNCSs simultaneously exhibit peroxidase (POD)- and catalase (CAT)-like activities, which not only can convert endogenous hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals ( OH) for catalytic therapy, but also decompose H2 O2 to oxygen (O2 ) to enhance O2 -dependent PDT.	Oxygen	240-242	catalase	Homo sapiens	66-69
32572684-10	2021	For patients with OSAHS, serum periostin and TNF-alpha levels positively correlated with the apnea-hypopnea index (AHI) (p < 0.01) and negatively correlated with the lowest saturation oxygen (LSaO2) and mean saturation oxygen (MSaO2) (both p < 0.01).	Oxygen	184-190	tumor necrosis factor	Homo sapiens	45-54
32572684-10	2021	For patients with OSAHS, serum periostin and TNF-alpha levels positively correlated with the apnea-hypopnea index (AHI) (p < 0.01) and negatively correlated with the lowest saturation oxygen (LSaO2) and mean saturation oxygen (MSaO2) (both p < 0.01).	Oxygen	219-225	tumor necrosis factor	Homo sapiens	45-54
32932001-4	2021	We demonstrated that hepcidin could significantly suppress the ICH-induced increase in iron and ferritin in brain tissues and CSF by inhibiting expression of iron transport proteins, increase neuronal survival by attenuating ICH-induced apoptosis, reactive oxygen species, neurodegeneration and brain edema, as well as effectively improve ICH-induced behavioral and cognitive deficit in rats.	Oxygen	257-263	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
33732230-8	2021	In addition, Ppard-deficient microglia exhibited increased expression of genes associated with reactive oxygen species generation, phagocytosis and lipid clearance, M2-activation, and promotion of inflammation.	Oxygen	104-110	peroxisome proliferator activator receptor delta	Mus musculus	13-18
33639987-9	2021	In vitro study elucidated that Notch 2 participated in the activation of ACE system and angiotensin II release, induced by midkine and triggered vascular endothelial injury by angiotensin II induced reactive oxygen species production.	Oxygen	208-214	angiotensinogen	Homo sapiens	88-102
33637118-5	2021	RESULTS: The generated CAFs exhibited a decrease in Caveolin-1 protein expression levels, a CAF biomarker, which was further enhanced when the coculture was maintained under in-vivo-like oxygen tension conditions.	Oxygen	187-193	caveolin 1	Homo sapiens	52-62
33718186-0	2021	Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck.	Oxygen	0-6	epidermal growth factor receptor	Homo sapiens	29-33
33718332-10	2020	Interestingly, cells cultivated in normoxia (21% O2) seem to be more sensitive to mTOR inhibition by rapamycin than those cultivated in hypoxia (0.4% O2).	Oxygen	49-51	mechanistic target of rapamycin kinase	Homo sapiens	82-86
33718186-5	2021	Reduced oxygen supply strongly downregulated EGFR protein levels and signaling in FaDu cells in vitro and in vivo, and a transient downregulation of EGFR signaling was found in three other HNSCC cell lines.	Oxygen	8-14	epidermal growth factor receptor	Homo sapiens	45-49
33560128-1	2021	Cytochrome c oxidase (CcO) in its as-isolated form is known to exist in a slow and fast form, which differ drastically in their ability to bind oxygen and other ligands.	Oxygen	144-150	Fas activated serine/threonine kinase	Homo sapiens	83-87
33670755-8	2021	Consistent with these results, the treatment of FaO cells, a rodent hepatoma cell line, with the AQP9 blocker HTS13268 prevented the LPS-induced increase of inflammatory NO and O2-.	Oxygen	177-180	aquaporin 9	Rattus norvegicus	97-101
33622439-8	2021	In parallel, our results indicated the upregulation of NFE2L2 in groups of oocytes cultured under high oxygen tension that was coupled with reduced mitochondrial activity.	Oxygen	103-109	NFE2 like bZIP transcription factor 2	Homo sapiens	55-61
33622439-9	2021	In contrast, the expression levels of MAPK14 and CPT2 genes were increased (P <= 0.05) in groups of oocytes cultured under low compared with high oxygen tension that was subsequently associated with increased mitochondrial activity.	Oxygen	146-152	mitogen-activated protein kinase 14	Homo sapiens	38-44
33421588-10	2021	S1QEL712, which has a distinct chemical structure, also decreased hepatic steatosis, confirming that O2.- derived specifically from mitochondrial site IQ is a significant driver of hepatic steatosis in Sod2-/- mice.	Oxygen	101-103	superoxide dismutase 2, mitochondrial	Mus musculus	202-206
33293086-6	2021	Yield residue analysis indicated that the high porosity and oxygen-containing functional groups of MFHGs remarkably improved their Co(II)- and Ni(II)-removal capacities.	Oxygen	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
33679753-7	2021	Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure.	Oxygen	108-114	interleukin 6	Homo sapiens	204-208
33679753-7	2021	Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure.	Oxygen	158-164	interleukin 6	Homo sapiens	58-62
33679753-7	2021	Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure.	Oxygen	158-164	interleukin 6	Homo sapiens	204-208
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	Oxygen	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33412146-0	2021	Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-kappaB pathway.	Oxygen	41-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	Oxygen	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33607153-0	2021	Long non-coding RNA RMST promotes oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells by regulating miR-204-5p/VCAM1 axis.	Oxygen	34-40	microRNA 204	Mus musculus	131-138
33586674-3	2021	We found that Sema3G was elevated in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and in the neovascularization regression phase of oxygen-induced retinopathy (OIR).	Oxygen	164-170	semaphorin 3G	Homo sapiens	14-20
33472844-0	2021	Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.	Oxygen	0-6	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	76-79
33481972-0	2021	Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response.	Oxygen	26-32	fibronectin 1	Homo sapiens	0-11
33481972-3	2021	In this study, polyurethane was treated with oxygen plasma, which allowed for a simultaneous modification of the surface chemistry and topography to modulate fibronectin adsorption.	Oxygen	45-51	fibronectin 1	Homo sapiens	158-169
33481972-9	2021	Our data suggest that oxygen plasma treatment is a reliable technique for the modulation of fibronectin adsorption in order to adjust fibronectin bioactivity and impact cell responses to implant surfaces.	Oxygen	22-28	fibronectin 1	Homo sapiens	92-103
33481972-9	2021	Our data suggest that oxygen plasma treatment is a reliable technique for the modulation of fibronectin adsorption in order to adjust fibronectin bioactivity and impact cell responses to implant surfaces.	Oxygen	22-28	fibronectin 1	Homo sapiens	134-145
33074310-6	2021	Continuous exposure of pregnant mice to hypoxia (10.5% O2) from E6.5 to E10.5 or to E18.5 led to reduction in fetal weight, and such fetal weight loss was markedly worsened in miR-210-knockout dams.	Oxygen	55-57	microRNA 210	Mus musculus	176-183
33673376-2	2021	The hypoxia-inducible factors (HIF-1alpha, HIF-2alpha, and HIF-3alpha), are the master regulators in response to low oxygen partial pressure, modulating hypoxic gene expression and signalling transduction pathways.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
33673376-2	2021	The hypoxia-inducible factors (HIF-1alpha, HIF-2alpha, and HIF-3alpha), are the master regulators in response to low oxygen partial pressure, modulating hypoxic gene expression and signalling transduction pathways.	Oxygen	117-123	hypoxia inducible factor 3 subunit alpha	Homo sapiens	59-69
33463639-3	2021	Under catalase catalysis, a high concentration of intracellular H2O2 can be transformed into O2.	Oxygen	66-68	catalase	Homo sapiens	6-14
33497181-0	2021	Catalase-Loaded Silica Nanoparticles Formulated via Direct Surface Modification as Potential Oxygen Generators for Hypoxia Relief.	Oxygen	93-99	catalase	Rattus norvegicus	0-8
33497181-10	2021	Finally, the ability of CAT-SiNPs to release oxygen (O2) when exposed to H2O2 was demonstrated in vivo using a rat model.	Oxygen	45-51	catalase	Rattus norvegicus	24-27
33497181-10	2021	Finally, the ability of CAT-SiNPs to release oxygen (O2) when exposed to H2O2 was demonstrated in vivo using a rat model.	Oxygen	53-55	catalase	Rattus norvegicus	24-27
33497181-11	2021	Following the direct injection of CAT-SiNPs in the left kidney, partial pressure of oxygen (pO2) increased by more than 30 mmHg compared to the contralateral control kidney during the systemic infusion of safe levels of H2O2.	Oxygen	84-90	catalase	Rattus norvegicus	34-37
33497181-12	2021	This pilot study highlights the potential of CAT-SiNPs to generate O2 to relieve hypoxia in tissues and potentially sensitize tumors against radiation therapy.	Oxygen	67-69	catalase	Rattus norvegicus	45-48
33898190-5	2021	By virtue of the regenerable catalytic hotspots of oxygen vacancies on the surface of CeNPs, PMNSs exhibit sustainable phosphatase-mimetic activity to dephosphorylate phosphoproteins in allergen-stimulated MCs.	Oxygen	51-57	centromere protein S	Homo sapiens	86-91
33125232-5	2021	The results obtained demonstrate the potential of triggered release of the PON-1 enzyme and its efficacy against the production of ox-LDL, and therefore a reduction in macrophage foam cell and reactive oxygen species formation.	Oxygen	202-208	paraoxonase 1	Homo sapiens	75-80
33860083-1	2021	Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electrons to oxygen to generate hydrogen peroxide (H2O2).	Oxygen	155-161	cytochrome p450 oxidoreductase	Homo sapiens	51-82
33860083-1	2021	Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electrons to oxygen to generate hydrogen peroxide (H2O2).	Oxygen	155-161	cytochrome p450 oxidoreductase	Homo sapiens	84-87
33091368-8	2021	This work defines mechanisms by which HIF1a impairs oligodendrocyte formation and establishes that cell-type-specific HIF1a targets perturb cell function in response to low oxygen.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-123
33628380-9	2021	Moreover, Ang II-infused mice showed increased Nlrp3 inflammasome activity relative to that of the cytokines IL-1beta and IL-18, increased reactive oxygen species, mitochondrial abnormalities, and decreased mtDNA copy number and ATP synthase activity.	Oxygen	148-154	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	10-16
33548224-4	2021	Hepatocytes isolated from liver-specific LRP1 knockout (hLrp1-/-) mice showed reduced oxygen consumption compared to control mouse hepatocytes.	Oxygen	86-92	LDL receptor related protein 1	Homo sapiens	56-61
33534785-9	2021	Instead, MesD requires an uncharacterized protein family (DUF1852) and oxygen for activity.	Oxygen	71-77	mesoderm development LRP chaperone	Homo sapiens	9-13
33603672-10	2021	Results: Inhibition of thioredoxin 1 by Px-12 triggered renal tubular cell oxidative injury as evidenced by morphological change, loss of cellular viability, over production of ROS and O2 -, and appearance of cleaved caspase-3.	Oxygen	185-189	thioredoxin 1	Rattus norvegicus	23-36
33555846-14	2021	Baseline tissue oxygen saturation was comparable and higher at both H3 and H6 in the Vasopressin group comparatively to the Norepinephrine group (p < 0.05) (Table 5).	Oxygen	16-22	vasopressin	Sus scrofa	85-96
33472361-4	2021	Increasing pH and/or decreasing oxygen promoted the conversion of nitrate (NO3-) into NO2- but suppressed the H2O2 formation, suggesting that there was a transition of radicals from oxidizing species like hydroxyl radicals to reducing species like hydrogen atoms and hydrated electrons.	Oxygen	32-38	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
33443631-0	2021	Enhanced human lysozyme production by Pichia pastoris via periodic glycerol and dissolved oxygen concentrations control.	Oxygen	90-96	lysozyme	Homo sapiens	15-23
33531400-7	2021	CD11b+ lung leukocytes isolated from infected Sirt3-/- mice showed decreased levels of enzymes involved in central mitochondrial metabolic pathways, along with increased reactive oxygen species.	Oxygen	179-185	integrin alpha M	Mus musculus	0-5
33448048-3	2021	Thus, g-C3 N4 /rGO/PDIP presents an efficient and stable photocatalytic overall water splitting activity with H2 and O2 evolution rate of 15.80 and 7.80 micromol h-1 , respectively,  12.1 times higher than g-C3 N4 nanosheets.	Oxygen	117-119	protein disulfide isomerase family A member 2	Homo sapiens	19-23
32935224-7	2021	Intravitreal injection of self-complementary adeno-associated viral vector (scAAV)-DHFR(DD)-Flt23k and subsequent administration of TMP resulted in tunable suppression of ischemia-induced retinal neovascularization in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	233-239	dihydrofolate reductase	Rattus norvegicus	83-87
33523764-6	2021	Compared to normoxia, hypoxia (0.2% O2) for 24 hr increased hypoxia inducible factor-1alpha-dependent NEDD9 upregulation in vitro.	Oxygen	36-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-91
33832411-11	2021	It was shown that hydrogen peroxide at concentration 100 microM, which is lower than the cytotoxicity threshold of H2O2 for cultured HUVEC, increased several times the number of dot-like structures and total amount of vWF exposed on plasma membrane of HUVEC, which suggest that H2O2 acts as a mediator that activates exocytosis of Weibel-Palade bodies and vWF secretion in the vascular endothelium during inflammation and upon elevated generation of endogenous reactive oxygen species in ECs.	Oxygen	470-476	von Willebrand factor	Homo sapiens	218-221
33508746-10	2021	INTERPRETATION: Renal interstitial fibroblasts function as central controllers of systemic oxygen delivery by producing both renin and erythropoietin.	Oxygen	91-97	renin	Homo sapiens	125-130
33271223-4	2021	Our results show that Adiponectin enhances basal mitochondrial oxygen consumption rate (OCR), ATP production, and spare respiratory capacity (SRC), which were all abolished by the knockdown of AMPKgamma1, inhibition of SDH complex assembly, via the knockdown of the SDH assembly factor 1 (Sdhaf1), or inhibition of SDH activity.	Oxygen	63-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	22-33
33831684-4	2021	Results showed that residual ozone with 0.05-0.10 mg L-1 in the BAF demonstrated relatively high chemical oxygen demand (COD) removal efficiency of 48.4%, which was 1.5-fold higher than that obtained by separated O3-BAF and 3-fold higher than that obtained by ordinary BAF.	Oxygen	106-112	BAF nuclear assembly factor 1	Homo sapiens	64-67
33841100-10	2021	Increased levels of ATP, restoration of mitochondrial membrane potential, and decreased production of mitochondrial reactive oxygen species after Abeta treatment in the presence of 4mu8c showed that inhibiting the IRE1alpha-XBP1 axis effectively mitigated Abeta-induced mitochondrial dysfunction in SH-SY5Y cells.	Oxygen	125-131	amyloid beta precursor protein	Homo sapiens	146-151
33841100-10	2021	Increased levels of ATP, restoration of mitochondrial membrane potential, and decreased production of mitochondrial reactive oxygen species after Abeta treatment in the presence of 4mu8c showed that inhibiting the IRE1alpha-XBP1 axis effectively mitigated Abeta-induced mitochondrial dysfunction in SH-SY5Y cells.	Oxygen	125-131	amyloid beta precursor protein	Homo sapiens	256-261
33253911-9	2021	In addition, the BDNF/KLF2 pathway preserved the mitochondrial membrane potential, intracellular reactive oxygen species generation, electron transport chain processing, oxygen consumption rate, and adenosine triphosphate production.	Oxygen	106-112	Kruppel like factor 2	Homo sapiens	22-26
33219433-6	2021	RESULTS: Maximal oxygen uptake was impaired in individuals with type 1 diabetes compared with in healthy participants (35.6 +- 7.7 vs 39.6 +- 6.8 ml min-1 kg-1, p < 0.01) despite comparable levels of habitual physical activity (moderate to vigorous physical activity by accelerometery, 234.9 +- 160.0 vs 280.1 +- 114.9 min/week).	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	149-159
33275947-5	2021	Dex suppressed the apoptosis of neuronal cells and production of reactive oxygen species induced by Abeta.	Oxygen	74-80	amyloid beta precursor protein	Homo sapiens	100-105
33215946-9	2021	EXPERT OPINION: Overall, the CYP enzymes, depending upon the isoform, play a contributory or protective role in hyperoxic lung injury, and are, therefore, ideal candidates for developing drugs that can treat oxygen-mediated lung injury.	Oxygen	208-214	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-32
33484198-7	2021	Moreover, TRPML1/STIM1 interplay changed at low-oxygen conditions: both proteins were downregulated during the ischemic preconditioning (IPC) while during IPC followed by 1 hour of normoxia, at which STIM1 is upregulated, TRPML1 protein was reduced.	Oxygen	48-54	stromal interaction molecule 1	Rattus norvegicus	17-22
33484198-8	2021	However, during oxygen and glucose deprivation (OGD) followed by reoxygenation, TRPML1 and STIM1 proteins peaked at 8 hours of reoxygenation, when the proteins were co-immunoprecipitated and reactive oxygen species (ROS) hyperproduction was measured in cortical neurons.	Oxygen	16-22	stromal interaction molecule 1	Rattus norvegicus	91-96
33002689-5	2021	The catalase can decompose the endogenous H2O2 in malignant cancerous cells into O2 bubble to simultaneously intensify the ultrasound (US) imaging signal and enhance PDT efficacy.	Oxygen	44-46	catalase	Homo sapiens	4-12
31959086-1	2021	Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism.	Oxygen	16-22	myoglobin	Gallus gallus	0-9
31959086-1	2021	Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism.	Oxygen	87-93	myoglobin	Gallus gallus	0-9
31959086-1	2021	Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism.	Oxygen	87-93	myoglobin	Gallus gallus	0-9
31959086-1	2021	Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism.	Oxygen	87-93	myoglobin	Gallus gallus	0-9
33084182-10	2021	In ApoE-/- ATD mice group a higher levels of deoxyhemoglobin was monitored indicating that the rate of oxygen release to the tissue is low.	Oxygen	103-109	apolipoprotein E	Mus musculus	3-7
33295887-7	2021	Mechanistically, downregulation of VLA4 or VCAM1 led to reduced levels of RAC1 and reactive oxygen species (ROS), which resulted in decreased phosphorylation of PYK2 (p-PYK2) and VE-cadherin (p-VE-cad), hence enhancing cell adhesion.	Oxygen	92-98	vascular cell adhesion molecule 1	Homo sapiens	43-48
33402303-8	2021	Comorbid cardiovascular disease, lymphocytopenia, elevated CRP, liver enzyme and D-dimer levels, and higher chest CT score were significantly associated with an increase in oxygen requirement CONCLUSIONS: The expanded CURB-65 score can be a better predictor of an increase in oxygen requirement in patients with SARS-CoV-2 pneumonia.	Oxygen	173-179	C-reactive protein	Homo sapiens	59-62
33205599-3	2021	Oxygen-sulfur exchange reaction (O-S ER) during the copolymerization of CS2 and EO, the generation and mutual copolymerization with COS, CO2 , and episulfide, is harnessed to introduce crystallizable segments [ SC( O)O  and  SC( S)S ] in the copolymer.	Oxygen	0-6	chorionic somatomammotropin hormone 2	Homo sapiens	72-75
33161117-2	2021	TNF-alpha receptors are expressed in brain stem regions involved in respiratory control and also in the carotid bodies, which are the sensory organs monitoring arterial blood O2.	Oxygen	175-177	tumor necrosis factor	Rattus norvegicus	0-9
33360237-2	2021	Based on salt-related transcriptomic data, we isolated a GRX family gene, glutaredoxin like protein (RtGRL1), from R. trigyna that is associated with the removal of active oxygen and regulation of redox status.	Oxygen	172-178	glutaredoxin-like protein	Arabidopsis thaliana	74-99
33573145-0	2021	Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury.	Oxygen	11-17	BCL2, apoptosis regulator	Rattus norvegicus	82-87
33572553-3	2021	We recently developed a water-floatable, bFGF-releasing membrane via a simple bFGF adsorption process following oxygen plasma treatment by utilizing a polyethylene nonwoven fabric as an adsorbent.	Oxygen	112-118	fibroblast growth factor 2	Homo sapiens	41-45
33510458-5	2021	TIGAR in turn facilitates pentose phosphate pathway flux to produce nicotinamide adenine dinucleotide phosphate (NADPH) and ribose, thereby promoting DNA repair, and reducing intracellular reactive oxygen species.	Oxygen	198-204	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	0-5
33053236-1	2021	RATIONALE: Oxygen isotope ratio measurements of NO2 - and NO3 - by the azide method and denitrifier method are sensitive to the delta18 O of sample water.	Oxygen	11-17	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
33514783-5	2021	Mice with a constitutive cardiac-specific deletion of CISD1 on the C57BL/6J background showed cardiac dysfunction only after 12 months of age and developed HF after 16 months; whereas irregular morphology and higher levels of reactive oxygen species in their cardiac mitochondria were observed at earlier time points.	Oxygen	235-241	CDGSH iron sulfur domain 1	Mus musculus	54-59
33524393-9	2021	Treatment of freshly isolated collecting ducts with Ang II led to production of reactive oxygen species on the same timescale as single channel ClC-K2 activation.	Oxygen	89-95	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	52-58
33507936-9	2021	For FOXO3A rs2802292, women"s body temperature and all participants" saturation of peripheral oxygen were lower in the G/T genotype than in the T/T genotype, with respective p values of 0.039 and 0.032.	Oxygen	94-100	forkhead box O3	Homo sapiens	4-10
33471997-3	2021	Here we find that surface Cu doping can bend down the band levels and decline the VBM of the CsPb1-xGexBr3 surface below the H2O/O2 potential, then prevent the Ge2+ from being oxidized into Ge4+ by water because the Cu dopant reduces the perovskite surface electron accumulation.	Oxygen	129-131	mitogen-activated protein kinase 14	Homo sapiens	93-98
33496749-6	2021	HIF-1alpha KD also restored mTOR activation in low O2 concentrations, and inhibiting mTOR in HIF1alpha KD T-ALL protected leukemic cells from chemotherapy.	Oxygen	51-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
33501881-0	2021	CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway.	Oxygen	40-46	C1q and TNF related 3	Homo sapiens	0-5
33585583-12	2020	In summary, we show that NHE1 responds to oxygen, a physiologically-relevant metabolic regulator, ostensibly to divert ATP for contraction.	Oxygen	42-48	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	25-29
33585583-13	2020	We describe a novel mechanism of NHE1 inhibition that may be relevant in cardiac disorders featuring altered oxygen metabolism, such as myocardial ischemia and reperfusion injury.	Oxygen	109-115	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	33-37
33500450-6	2021	The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity.	Oxygen	4-10	superoxide dismutase 1	Homo sapiens	234-237
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	Oxygen	111-117	apelin	Homo sapiens	17-23
33575659-1	2021	Purpose: To assess the cell-specific, intracellular partial pressure of oxygen (Po2) dynamics of both tumor and chimeric antigen receptor (CAR) T cells in a murine immunotherapy model.	Oxygen	72-78	nuclear receptor subfamily 1, group I, member 3	Mus musculus	112-137
33388412-1	2021	HIF-1alpha acts as the cellular rheostat for oxygen sensing in cardiomyocytes.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
33575659-1	2021	Purpose: To assess the cell-specific, intracellular partial pressure of oxygen (Po2) dynamics of both tumor and chimeric antigen receptor (CAR) T cells in a murine immunotherapy model.	Oxygen	72-78	nuclear receptor subfamily 1, group I, member 3	Mus musculus	139-142
33477205-5	2021	Insulin acutely activated the PI3K/Akt/mTOR pathway in monocytes and increased both oxygen consumption and glycolytic rates.	Oxygen	84-90	insulin	Homo sapiens	0-7
33477205-6	2021	Functionally, acute exposure to insulin increased LPS-induced IL-6 secretion and reactive oxygen species production.	Oxygen	90-96	insulin	Homo sapiens	32-39
33419940-6	2021	AHL13 knockout mutant plants are compromised in pathogen-associated molecular pattern (PAMP)-induced reactive oxygen species production, expression of defense genes, and PAMP-triggered immunity.	Oxygen	110-116	AT hook motif DNA-binding family protein	Arabidopsis thaliana	0-5
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	107-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	13-20
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	144-150	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	13-20
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	144-150	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	13-20
33553145-2	2020	This study demonstrates that the pluripotency-promoting PI3K/AKT signaling pathway is surprisingly attenuated in mild hypoxia compared to the 21% O2 environment.	Oxygen	146-148	AKT serine/threonine kinase 1	Homo sapiens	61-64
33498264-2	2021	Complex IV, or cytochrome c oxidase (COX), is the terminal enzyme of the electron transport chain, responsible for accepting electrons from cytochrome c, pumping protons to contribute to the gradient utilized by ATP synthase to produce ATP, and reducing oxygen to water.	Oxygen	254-260	cytochrome c, somatic	Homo sapiens	15-27
33498264-2	2021	Complex IV, or cytochrome c oxidase (COX), is the terminal enzyme of the electron transport chain, responsible for accepting electrons from cytochrome c, pumping protons to contribute to the gradient utilized by ATP synthase to produce ATP, and reducing oxygen to water.	Oxygen	254-260	cytochrome c, somatic	Homo sapiens	140-152
33527004-3	2021	Electrons are transferred from reduced cytochrome c to molecular oxygen and play an indispensable role in oxidative phosphorylation of cells.	Oxygen	65-71	cytochrome c, somatic	Homo sapiens	39-51
33461459-2	2021	BACKGROUND: Current pharmacokinetic investigations consider reactive oxygen species formed in microsomal reactions as toxic waste products, whereas our works (Manoj et al., 2016) showed that DROS are the reaction mainstay in cytochrome P450 mediated metabolism and that they play significant roles in explaining several unexplained physiologies (Parashar et al., 2018).	Oxygen	69-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	225-240
33259795-2	2021	To combat this threat, the cell employs the enzyme Cu/Zn Superoxide Dismutase (SOD1), which can convert the radical superoxide into molecular oxygen and hydrogen peroxide, through redox reactions.	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	51-77
33259795-2	2021	To combat this threat, the cell employs the enzyme Cu/Zn Superoxide Dismutase (SOD1), which can convert the radical superoxide into molecular oxygen and hydrogen peroxide, through redox reactions.	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	79-83
33249098-0	2021	Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.	Oxygen	33-39	progestin and adipoQ receptor family member 3	Rattus norvegicus	10-15
33441543-5	2021	We could further show that NRF2 is paramount for proliferation, ROS elimination, and radioprotection under constant hypoxia (1% O2), but is dispensable under normoxic conditions or after reoxygenation.	Oxygen	128-130	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
33510583-11	2021	Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-kappaB-dependent inflammatory response and protects SIRT1/PGC-1alpha-dependent mitochondrial function.	Oxygen	18-21	toll-like receptor 4	Mus musculus	93-97
33510583-11	2021	Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-kappaB-dependent inflammatory response and protects SIRT1/PGC-1alpha-dependent mitochondrial function.	Oxygen	18-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
32800928-11	2021	However, a specific JNK inhibitor inhibited the fMLF-induced O2 - generation and CD11b expression, but it had no effect on [Ca2+]i in human neutrophils.	Oxygen	61-63	mitogen-activated protein kinase 8	Homo sapiens	20-23
33441751-5	2021	Cytoglobin also protects cells from cisplatin-induced apoptosis and oxidative stress with levels of the antioxidant glutathione increased and total and mitochondrial reactive oxygen species levels reduced.	Oxygen	175-181	cytoglobin	Homo sapiens	0-10
33323505-3	2021	Here we report that hypoxia (1 % oxygen) increases protein levels and catalytic activity of PTP-PEST in primary endothelial cells.	Oxygen	33-39	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	92-100
33422127-8	2021	Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3alpha (HIF3alpha), peroxisome proliferator-activated receptor alpha (PPARalpha), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS.	Oxygen	72-78	hypoxia inducible factor 3 subunit alpha	Homo sapiens	113-144
33490043-3	2020	It is found that refractive index and density gradually decrease with increasing BaF2 content from 0 to 9 mol.%, due to the generation of more non-bridging oxygens.	Oxygen	156-163	BANF family member 2	Homo sapiens	81-85
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	angiotensin I converting enzyme	Rattus norvegicus	135-164
32996287-3	2021	The model shows that this system can achieve a biomass productivity of ~1.7 g L -1 hr -1 but is limited by a competitive trade-off between O 2 gas/liquid mass transfer and CO 2 transport to the cathode.	Oxygen	139-142	L1 cell adhesion molecule	Homo sapiens	78-88
33488521-5	2020	In summary, GH and/or IGF-I appear to be significant determinants of systemic and local brain Hb concentrations through mediating responses to oxygen and metabolic demand, as part of the neuroprotective effects exerted by GH and IGF-I.	Oxygen	143-149	growth hormone 1	Homo sapiens	12-14
33488521-5	2020	In summary, GH and/or IGF-I appear to be significant determinants of systemic and local brain Hb concentrations through mediating responses to oxygen and metabolic demand, as part of the neuroprotective effects exerted by GH and IGF-I.	Oxygen	143-149	insulin like growth factor 1	Homo sapiens	22-27
33413477-0	2021	Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment.	Oxygen	122-128	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	angiotensin I converting enzyme	Rattus norvegicus	166-169
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	angiotensinogen	Rattus norvegicus	211-234
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	collagen type I alpha 1 chain	Rattus norvegicus	236-259
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	collagen type I alpha 1 chain	Rattus norvegicus	261-271
33488404-12	2020	Oxygen enrichment inhibited medial thickening, stenosis and fibrosis of pulmonary arterioles, and cytokine expression related with fibrosis (Col1alpha1, Col3alpha1, and hydroxyproline) and pulmonary vasoconstriction [endothelin-1(ET-1)] in HAH-exposed rats.	Oxygen	0-6	endothelin 1	Rattus norvegicus	217-229
33488404-12	2020	Oxygen enrichment inhibited medial thickening, stenosis and fibrosis of pulmonary arterioles, and cytokine expression related with fibrosis (Col1alpha1, Col3alpha1, and hydroxyproline) and pulmonary vasoconstriction [endothelin-1(ET-1)] in HAH-exposed rats.	Oxygen	0-6	endothelin 1	Rattus norvegicus	230-234
33488380-8	2020	These data demonstrate that supraphysiological oxygen exposure during the critical neonatal developmental period leads to pathologically heightened CA3-CA1 synaptic function during early adulthood which may contribute to hippocampal shrinkage and learning and memory deficits we previously reported.	Oxygen	47-53	carbonic anhydrase 3	Mus musculus	148-151
33407494-3	2021	METHODS: PlGF was knocked down in H358 and H1975 cells by lentiviruses, which were then cultured under hypoxia (90% N2, 5%CO2 and 5%O2) for 24 h. PlGF was overexpressed in PC9 cells treated with XAV939, inhibitor of Wnt/beta-catenin signaling pathway.	Oxygen	123-125	placental growth factor	Homo sapiens	9-13
33080102-5	2021	That complex displays a high spin tetrahedral Co II center, which is reactive towards external substrates including dioxygen.	Oxygen	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
33466421-1	2021	The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-225
33466421-1	2021	The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	227-237
33466421-1	2021	The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-225
33466421-1	2021	The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1alpha (HIF-1alpha) transcription factor activity.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	227-237
33471350-10	2021	CONCLUSIONS: ROX is a simple noninvasive promising tool for predicting discontinuation of high-flow oxygen therapy and could be used in the assessment of progress and the risk of intubation in COVID-19 patients with pneumonia.	Oxygen	100-106	MAX network transcriptional repressor	Homo sapiens	13-16
33398040-4	2021	We found that DOPAL is able to stabilize Abeta oligomeric species, including dimers and trimers, that exert toxic effects on human neuroblastoma cells, in particular increasing cytosolic calcium levels and promoting the generation of reactive oxygen species.	Oxygen	243-249	amyloid beta precursor protein	Homo sapiens	41-46
33264010-6	2021	In addition, we showed an enhanced generation of reactive oxygen species in the HepG2 cells, which could be inhibited by the natural ligand of ASGPR.	Oxygen	58-64	asialoglycoprotein receptor 1	Homo sapiens	143-148
34053023-10	2021	Finally, we will present an overview of the current primary scientific literature of how 2PLM has been used for oxygen sensing in biological applications and how this technique is improving our understanding of the basic biology underlying several areas of human health.	Oxygen	112-118	FXYD domain containing ion transport regulator 1	Homo sapiens	90-93
33406653-0	2021	Oxygen Saturation Imaging Using LED-Based Photoacoustic System.	Oxygen	0-6	small integral membrane protein 10 like 2A	Homo sapiens	32-35
33406653-2	2021	Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case.	Oxygen	46-52	small integral membrane protein 10 like 2A	Homo sapiens	16-19
33406653-4	2021	We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration.	Oxygen	33-39	small integral membrane protein 10 like 2A	Homo sapiens	260-263
33202114-0	2021	A triple sense of oxygen promotes neurovascular angiogenesis in NG2-derived cells.	Oxygen	18-24	chondroitin sulfate proteoglycan 4	Homo sapiens	64-67
33202114-3	2021	1 demonstrate how NG2-derived cells in the brain sense oxygen to promote neurovascular angiogenesis.	Oxygen	55-61	chondroitin sulfate proteoglycan 4	Homo sapiens	18-21
32526061-7	2021	PDE5 inhibition favors an anti-inflammatory response by modulating activated T cells, reducing cytokine release, lowering fibrosis, increasing oxygen diffusion, stimulating vascular repair.	Oxygen	143-149	phosphodiesterase 5A	Homo sapiens	0-4
33146568-9	2021	Associated with mitochondrial biogenesis, TNFalpha exposure also increased mitochondrial volume density and porin expression, resulting in an increase in maximum O2 consumption rate.	Oxygen	162-164	tumor necrosis factor	Homo sapiens	42-50
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	interleukin 1 beta	Mus musculus	242-260
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	101-105	superoxide dismutase 1	Homo sapiens	0-26
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	101-105	superoxide dismutase 1	Homo sapiens	28-32
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	112-118	superoxide dismutase 1	Homo sapiens	0-26
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	112-118	superoxide dismutase 1	Homo sapiens	28-32
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	0-26
33218686-1	2021	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2 -) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	28-32
33166886-3	2021	The ring-disk electrode (RDE) results further proved that the oxygen reduction reaction (ORR) occurred on the Fe(por)-0.05 through a direct four-electron transfer pathway.	Oxygen	62-68	cytochrome p450 oxidoreductase	Homo sapiens	110-117
33146568-10	2021	However, when normalized for mitochondrial volume density, O2 consumption rate per mitochondrion was reduced by TNFalpha exposure.	Oxygen	59-61	tumor necrosis factor	Homo sapiens	112-120
33791407-0	2021	Changes in Body Weight and Serum Albumin Levels in Patients Requiring Home Long-term Oxygen Therapy.	Oxygen	85-91	albumin	Homo sapiens	33-40
33378978-4	2021	Licochalcone A also enhances intracellular oxygen content by directly inhibiting mitochondrial respiration, resulting in oxygen-dependent HIF-1alpha degradation.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
33378978-4	2021	Licochalcone A also enhances intracellular oxygen content by directly inhibiting mitochondrial respiration, resulting in oxygen-dependent HIF-1alpha degradation.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
33039559-4	2021	The activity of HIF-1 is regulated by the stability of HIF-1a subunit, which is hydroxylated by oxygen-dependent prolyl hydroxylase enzymes, the PHDs.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
33039559-4	2021	The activity of HIF-1 is regulated by the stability of HIF-1a subunit, which is hydroxylated by oxygen-dependent prolyl hydroxylase enzymes, the PHDs.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-61
33022540-4	2021	Catalase enzyme was grafted onto the microsphere surfaces to accelerate the conversion of hydrogen peroxide (H2O2) to oxygen and prevent the accumulation of H2O2 and cell damages.	Oxygen	118-124	catalase	Homo sapiens	0-8
32827707-6	2021	TNFSF15 induced PDK1-dependent bacterial uptake and promoted intracellular bacterial clearance through reactive oxygen species, NOS2 and autophagy upregulation.	Oxygen	112-118	TNF superfamily member 15	Homo sapiens	0-7
32914726-1	2021	AIM: Hypoxia-inducible factor 1 (HIF-1) is responsible in regulating oxygen homeostasis in tissues.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	5-31
33115825-6	2021	We uncovered deficits in insulin secretion, partly due to reduced mitochondrial oxygen consumption rate, glucose-stimulated Ca2+ flux, and reduced insulin content associated with loss of eIF4E, the mRNA 5"-cap binding protein of the initiation complex and binding partner of eIF4G1.	Oxygen	80-86	insulin	Homo sapiens	25-32
33022540-5	2021	CPO loaded PLLA microspheres-graft-catalase could provide dissolved oxygen and calcium ions in release media up to 15 days.	Oxygen	68-74	catalase	Homo sapiens	35-43
33022540-9	2021	Based on these results, CPO loaded PLLA microspheres-graft-catalase, with the ability of cell carrying and controlled release of oxygen and calcium ions, can be a promising injectable cell microcarrier system for regeneration of bone tissue defects.	Oxygen	129-135	catalase	Homo sapiens	59-67
32368968-8	2021	Under this metabolic gridlock, the low oxygen and pro-inflammatory environments promoted the adipose breakdown with sequential metabolic dysregulation, including insulin resistance, systemic inflammation, and clinical NCDs progression.	Oxygen	39-45	insulin	Homo sapiens	162-169
32914726-1	2021	AIM: Hypoxia-inducible factor 1 (HIF-1) is responsible in regulating oxygen homeostasis in tissues.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
33220258-6	2021	In the present study, it was demonstrated that inhibiting the expression of PGC1alpha decreased nuclear and mitochondrial DNA transcription factor expression, leading to increased lactic acid production and decreased cellular oxygen consumption and mitochondrial oxidative phosphorylation.	Oxygen	226-232	PPARG coactivator 1 alpha	Homo sapiens	76-85
32912961-2	2021	SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen.	Oxygen	154-160	interleukin 6	Homo sapiens	91-104
32912961-2	2021	SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen.	Oxygen	154-160	interleukin 6	Homo sapiens	106-110
31264511-6	2021	The reaction time in which oxygen evolution happpens depends on the concentration of catalyst used in the oxidation, verifying that the highest oxygen generation rates are obtained when applying [Fe]0 = 10.0 mg L-1.	Oxygen	27-33	L1 cell adhesion molecule	Homo sapiens	211-214
31264511-6	2021	The reaction time in which oxygen evolution happpens depends on the concentration of catalyst used in the oxidation, verifying that the highest oxygen generation rates are obtained when applying [Fe]0 = 10.0 mg L-1.	Oxygen	144-150	L1 cell adhesion molecule	Homo sapiens	211-214
31264511-8	2021	The stages of formation and decrease of oxygen are adjusted to zero-order kinetics, estimating the kinetics constants as a function of the catalyst concentration: kf = 29.48 [Fe]0-1.25 (mg O2 L-1 min-1) and kd = -0.006 [Fe]0 2.0 + 0.244 [Fe]0-3.69 (mg O2 L-1 min-1).	Oxygen	40-46	L1 cell adhesion molecule	Homo sapiens	192-195
31264511-8	2021	The stages of formation and decrease of oxygen are adjusted to zero-order kinetics, estimating the kinetics constants as a function of the catalyst concentration: kf = 29.48 [Fe]0-1.25 (mg O2 L-1 min-1) and kd = -0.006 [Fe]0 2.0 + 0.244 [Fe]0-3.69 (mg O2 L-1 min-1).	Oxygen	189-191	L1 cell adhesion molecule	Homo sapiens	192-195
31264511-8	2021	The stages of formation and decrease of oxygen are adjusted to zero-order kinetics, estimating the kinetics constants as a function of the catalyst concentration: kf = 29.48 [Fe]0-1.25 (mg O2 L-1 min-1) and kd = -0.006 [Fe]0 2.0 + 0.244 [Fe]0-3.69 (mg O2 L-1 min-1).	Oxygen	189-191	L1 cell adhesion molecule	Homo sapiens	255-258
33612545-3	2021	Hypoxia inducible factor-1alpha (HIF-1alpha) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
33309651-3	2021	This was followed by oxidative fragmentation of ring B to the 9,10-secotigliane derivative 6 and oxidation of the endocyclic Delta6 double bond to the C-6/C-10 oxygen bridged 7-oxotigliane 7.	Oxygen	160-166	homeobox C10	Homo sapiens	155-159
33140223-1	2021	Generation of nitric oxide (NO) by the nitric oxide synthase (NOS) enzymes plays multiple signalling roles in every organ system, with crucial roles in the cardiovascular system, mediated by endothelial nitric oxide synthase (eNOS, encoded by NOS3) and neuronal nitric oxide synthase (nNOS, encoded by NOS1) in regulation of blood pressure, flow, oxygen delivery and cardiac function.	Oxygen	347-353	nitric oxide synthase 3	Homo sapiens	226-230
33140223-1	2021	Generation of nitric oxide (NO) by the nitric oxide synthase (NOS) enzymes plays multiple signalling roles in every organ system, with crucial roles in the cardiovascular system, mediated by endothelial nitric oxide synthase (eNOS, encoded by NOS3) and neuronal nitric oxide synthase (nNOS, encoded by NOS1) in regulation of blood pressure, flow, oxygen delivery and cardiac function.	Oxygen	347-353	nitric oxide synthase 3	Homo sapiens	243-247
33045281-8	2021	An IL-6-based algorithm had 98% sensitivity and 0.04 negative likelihood ratio (NLR) for 30-day oxygen requirement.	Oxygen	96-102	interleukin 6	Homo sapiens	3-7
33612545-3	2021	Hypoxia inducible factor-1alpha (HIF-1alpha) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
32951013-4	2021	RESULT: Initiation of vasopressin was followed by improved mean (p = 0.004), systolic (p = 0.028), and diastolic (p = 0.009) arterial pressure within 2 h. Heart rate (p = 0.025) and oxygen requirement (p = 0.021) also declined after initiation.	Oxygen	182-188	arginine vasopressin	Homo sapiens	22-33
33045281-9	2021	CONCLUSION: sTREM-1 and IL-6 concentrations in COVID-19 in the ED have good predictive accuracy for intubation/mortality and oxygen requirement.	Oxygen	125-131	interleukin 6	Homo sapiens	24-28
33219317-7	2021	Flow cytometry analysis showed that UFBP1 expression increases while UFBP1 knockdown reduces reactive oxygen species upon cisplatin treatment.	Oxygen	102-108	DDRGK domain containing 1	Homo sapiens	69-74
32644208-0	2021	Erythropoietin-induced hemoglobin subunit beta may stimulate innate immune RNA virus pattern recognition, suppress reactive oxygen species, reduce ACE2 viral doorway opening, and neutrophil extracellular traps against COVID-19.	Oxygen	124-130	erythropoietin	Homo sapiens	0-14
33357779-5	2021	This prevented the Ang II-induced upregulation of NAD(P)H oxidase (the NOX4 and p22phox subunits) and reactive oxygen species.	Oxygen	111-117	angiotensinogen	Homo sapiens	19-25
33246695-1	2021	Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor that regulates gene expressions in response to decreased oxygen levels in the tissue, or hypoxia.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
33246695-1	2021	Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor that regulates gene expressions in response to decreased oxygen levels in the tissue, or hypoxia.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
33246695-8	2021	With this regard, we suggested that interventions to elevate the HIF-1 levels in the brain, including the intermittent hypoxia conditioning and hyperbaric oxygen therapy, might be considered as new additional treatments for depression.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
31137981-5	2021	In silico docking studies resulted in discovery of oxygen containing naphthofuran and nitrogen and oxygen containing pyrano quinolizine tricyclic lead scaffolds as novel PDE5A inhibitors.	Oxygen	51-57	phosphodiesterase 5A	Homo sapiens	170-175
31137981-5	2021	In silico docking studies resulted in discovery of oxygen containing naphthofuran and nitrogen and oxygen containing pyrano quinolizine tricyclic lead scaffolds as novel PDE5A inhibitors.	Oxygen	99-105	phosphodiesterase 5A	Homo sapiens	170-175
33220616-10	2021	Our observation of a decrease in dHb, a corresponding increase in sO2, as well as greater HIF-1alpha expression only in UM-SCC-47 tumors strongly suggests that the reoxygenation within these tumors is due to a decrease in oxygen consumption in the cancer cells, which could potentially play a role in promoting radiation resistance.	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
33278780-10	2021	Protein levels of HIF1alpha and phosphorylation levels of the PI3K/AKT signaling pathway were upregulated in the context of 3% oxygen.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-27
32870357-4	2021	Twin B was subjected to sub-physiological flows (152 mL/kg/min) and oxygen delivery (15.9 mL/kg/min), while Twin A was maintained at physiological levels.	Oxygen	68-74	TWIN	Ovis aries	0-4
32926249-9	2021	Interestingly, less accumulation of ROS (H2O2 and O2-) was observed in CAX3-expressing transgenic plants and was accompanied with higher antioxidant enzyme activities (SOD, CAT, GR).	Oxygen	50-53	cation exchanger 3	Arabidopsis thaliana	71-75
33278780-10	2021	Protein levels of HIF1alpha and phosphorylation levels of the PI3K/AKT signaling pathway were upregulated in the context of 3% oxygen.	Oxygen	127-133	AKT serine/threonine kinase 1	Homo sapiens	67-70
33318918-5	2021	Both patients recovered rapidly and were successfully extubated and discharged from the hospital without need for supplemental oxygen shortly thereafter, and their clinical improvement correlated with response in interleukin-6 levels.	Oxygen	127-133	interleukin 6	Homo sapiens	213-226
33340902-6	2021	SIA removal disrupted kinase signaling involved in the nuclear accumulation of Nrf2 elicited by USS and promoted mitochondrial reactive oxygen species accumulation.	Oxygen	136-142	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
33378577-0	2021	Predictors of the maximal oxygen consumption in adult patients with type 1 diabetes treated with personal insulin pumps.	Oxygen	26-32	insulin	Homo sapiens	106-113
32122268-7	2021	Stem cell/oxygen-releasing HP system increased cGMP level and nNOS, eNOS, a-SMA and M3 expression, while decreasing fibrosis and apoptosis in the corpus cavernosum.	Oxygen	10-16	nitric oxide synthase 3	Homo sapiens	68-72
32122268-7	2021	Stem cell/oxygen-releasing HP system increased cGMP level and nNOS, eNOS, a-SMA and M3 expression, while decreasing fibrosis and apoptosis in the corpus cavernosum.	Oxygen	10-16	actin alpha 1, skeletal muscle	Homo sapiens	74-79
33645072-18	2021	The network pharmacology analysis showed that the action targets were significantly enriched in 129 of biological processes, such as response to organic substance, chemical and oxygen-containing compound, etc., as well as 16 of signal pathways, such as IL-17, TNF and hepatitis B signal pathways, were enriched too.	Oxygen	177-183	tumor necrosis factor	Mus musculus	260-263
33382742-2	2020	Hypoxia-inducible factor 1 alpha (HIF-1alpha)-a crucial oxygen sensor stabilized during hypoxic conditions-has been shown to have both activating and inhibitory effects in immune cells in a context- and cell-dependent manner.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
33382742-2	2020	Hypoxia-inducible factor 1 alpha (HIF-1alpha)-a crucial oxygen sensor stabilized during hypoxic conditions-has been shown to have both activating and inhibitory effects in immune cells in a context- and cell-dependent manner.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
33396202-3	2020	Activation of LH-receptor in rat Leydig cells ex and in vivo triggered cAMP, increased oxygen consumption, mitoenergetic and steroidogenic activities.	Oxygen	87-93	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	14-25
33087445-6	2020	We found that sildenafil, a phosphodiesterase 5 (PDE5) inhibitor induced mitochondrial biogenesis as measured by increased uncoupled oxygen consumption, mitochondrial DNA content and voltage-dependent anion channel protein expression.	Oxygen	133-139	phosphodiesterase 5A	Homo sapiens	49-53
33370292-3	2020	Here we report and experimentally validate a common physiological mechanism across multiple high-altitude songbirds that improvement in insulin sensitivity contributes to glucose homeostasis, low oxygen consumption, and relative activity, and thus increases body weight.	Oxygen	196-202	insulin	Homo sapiens	136-143
33356884-5	2021	Our results showed that Nicaraven significantly reduced the reactive oxygen species production after TNFalpha stimulation.	Oxygen	69-75	tumor necrosis factor	Homo sapiens	101-109
33231425-0	2020	NiCoO2@CeO2 Nanoboxes for Ultrasensitive Electrochemical Immunosensing Based on the Oxygen Evolution Reaction in a Neutral Medium: Application for Interleukin-6 Detection.	Oxygen	84-90	interleukin 6	Homo sapiens	147-160
33325020-0	2020	Hyperbaric oxygen but not hyperbaric air increases insulin sensitivity in men with type 2 diabetes mellitus.	Oxygen	11-17	insulin	Homo sapiens	51-58
33325020-1	2020	INTRODUCTION: We have previously shown that hyperbaric oxygen treatment (HBOT) increased insulin sensitivity in men who were obese or overweight, both with and without type 2 diabetes.	Oxygen	55-61	insulin	Homo sapiens	89-96
33325020-12	2020	CONCLUSIONS: The pathway by which insulin sensitivity is increased in men with type 2 diabetes requires the high oxygen partial pressures of HBOT and should be further investigated.	Oxygen	113-119	insulin	Homo sapiens	34-41
33271013-0	2020	Secondary Chemical Bonding between Insoluble Calcium Oxalate and Carbonyl Oxygen Atoms of GLY and VAL Residues Triggers the Formation of Abeta Aggregates and Their Deposition in the Brain.	Oxygen	74-80	amyloid beta precursor protein	Homo sapiens	137-142
33166462-0	2020	Electrons in Oxygen Vacancies and Oxygen Atoms Activated by Ce3+/Ce4+ Promote High-Sensitive Electrochemical Detection of Pb(II) over Ce-Doped alpha-MoO3 Catalysts.	Oxygen	13-19	submaxillary gland androgen regulated protein 3B	Homo sapiens	122-128
33166462-0	2020	Electrons in Oxygen Vacancies and Oxygen Atoms Activated by Ce3+/Ce4+ Promote High-Sensitive Electrochemical Detection of Pb(II) over Ce-Doped alpha-MoO3 Catalysts.	Oxygen	34-40	submaxillary gland androgen regulated protein 3B	Homo sapiens	122-128
33166462-5	2020	X-ray absorption fine structure spectra and density functional theory calculation indicate that Pb(II) was bonded with the surface-activated oxygen atoms (Os) around Ce ions and obtained some electrons from Os.	Oxygen	141-147	submaxillary gland androgen regulated protein 3B	Homo sapiens	96-102
33348622-2	2020	Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone.	Oxygen	110-116	protoporphyrinogen oxidase	Homo sapiens	22-40
33348622-2	2020	Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone.	Oxygen	110-116	protoporphyrinogen oxidase	Homo sapiens	42-45
33328510-4	2020	In this study, we demonstrate that the expressions of HOTAIRM1 and its target HOXA1 are substantially upregulated to promote the expressions of immunosuppressive molecules, including arginase 1, inducible nitric oxide synthase, signal transducer and activator of transcription 3, and reactive oxygen species, in CD33+ myeloid cells derived from hepatitis C virus (HCV)-infected patients.	Oxygen	293-299	HOXA transcript antisense RNA, myeloid-specific 1	Homo sapiens	54-62
33328510-4	2020	In this study, we demonstrate that the expressions of HOTAIRM1 and its target HOXA1 are substantially upregulated to promote the expressions of immunosuppressive molecules, including arginase 1, inducible nitric oxide synthase, signal transducer and activator of transcription 3, and reactive oxygen species, in CD33+ myeloid cells derived from hepatitis C virus (HCV)-infected patients.	Oxygen	293-299	signal transducer and activator of transcription 3	Homo sapiens	228-278
33328510-4	2020	In this study, we demonstrate that the expressions of HOTAIRM1 and its target HOXA1 are substantially upregulated to promote the expressions of immunosuppressive molecules, including arginase 1, inducible nitric oxide synthase, signal transducer and activator of transcription 3, and reactive oxygen species, in CD33+ myeloid cells derived from hepatitis C virus (HCV)-infected patients.	Oxygen	293-299	CD33 molecule	Homo sapiens	312-316
33318569-6	2020	miR-210 reconstitution restores the metabolic balance in diabetic wounds by reducing oxygen consumption rate and ROS production and by activating glycolysis with positive consequences on cellular migration.	Oxygen	85-91	microRNA 210	Mus musculus	0-7
32881223-1	2020	A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed.	Oxygen	83-89	catalase	Homo sapiens	30-38
33327261-3	2020	Hypoxia inducible factor 1alpha (HIF-1alpha) is a transcriptional factor that maintains oxygen homeostasis.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
33362773-10	2020	Metabolically, NLRX1 KO hearts displayed increased lactate production and glucose oxidation relative to fatty acid oxidation, associated with increased pyruvate dehydrogenase flux and 10% higher cardiac oxygen consumption.	Oxygen	203-209	NLR family member X1	Mus musculus	15-20
33238090-4	2020	For that, highly porous eFMs were activated using oxygen plasma treatment followed by amine insertion, which allows the immobilization of fibronectin through EDC/NHS chemistry.	Oxygen	50-56	fibronectin 1	Homo sapiens	138-149
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	endothelin 1	Rattus norvegicus	455-459
33327261-3	2020	Hypoxia inducible factor 1alpha (HIF-1alpha) is a transcriptional factor that maintains oxygen homeostasis.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
33456665-13	2020	Similar changes in the intracellular Ca2+ concentration, CAPN-2 expression, and CAPN-2 activity were observed when cells were exposed to oxygen-glucose deprivation and reperfusion (OGD/R) and transfected with synthetic miRs in vitro.	Oxygen	137-143	calpain 2	Rattus norvegicus	80-86
33321687-0	2020	Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y Cells.	Oxygen	84-90	poly(ADP-ribose) polymerase 1	Homo sapiens	59-63
33237755-6	2020	Using the two-photon fluorescence imaging, we found that peroxisomal O2 - rose during oxidative stress in the mouse brains, resulting in the inactivation of catalase (CAT).	Oxygen	69-73	catalase	Mus musculus	157-165
33237755-6	2020	Using the two-photon fluorescence imaging, we found that peroxisomal O2 - rose during oxidative stress in the mouse brains, resulting in the inactivation of catalase (CAT).	Oxygen	69-73	catalase	Mus musculus	167-170
33299012-6	2020	Comprehensive screening of BEX2 binding proteins identified E3 ubiquitin ligase complex proteins, FEM1B and CUL2, and a mitochondrial protein TUFM, and further demonstrated that knockdown of BEX2 or TUFM increased mitochondria-related oxygen consumption and decreased tumorigenicity in cholangiocarcinoma cells.	Oxygen	235-241	Tu translation elongation factor, mitochondrial	Homo sapiens	199-203
32947702-7	2020	Mechanism investigation suggested that the oxygen vacancies, redox cycles of Co(II)/Co(III) and S22-/(S2- and sulfate species) on the surface of 0.2CoAl-LDH@CoSx were crucial for PMS activation.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33297453-1	2020	beta3-adrenoreceptor (beta3-AR), a G-protein coupled receptor, has peculiar regulatory properties in response to oxygen and widespread localization.	Oxygen	113-119	adenosine A3 receptor	Homo sapiens	22-30
33291318-7	2020	Furthermore, HG levels and P2X7R agonist treatment led to increased expression of pro-inflammatory mediators (TLR-4, IL-1beta, IL-6, TNF-alpha, and IL-8) and other molecular markers (P2X7R, VEGF-A, and ICAM-1), along with enhanced production of reactive oxygen species.	Oxygen	254-260	purinergic receptor P2X 7	Homo sapiens	27-32
33290258-1	2020	Bnip3, which is regulated by Hif-1 in cells under oxygen deprivation, is a death related protein associated with autophagy and apoptosis.	Oxygen	50-56	BCL2 interacting protein 3	Homo sapiens	0-5
33290258-1	2020	Bnip3, which is regulated by Hif-1 in cells under oxygen deprivation, is a death related protein associated with autophagy and apoptosis.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
33273499-6	2020	The PLIM images clearly visualized the O2 gradient in hepatic lobules with cellular-level resolution, and the O2 levels were derived based on calibration using cultured cells; the phosphorescence lifetime of Ir-1 gave reasonable O2 levels, whereas Ir-2 exhibited much lower O2 levels.	Oxygen	110-112	immune response 1	Mus musculus	208-212
32926854-7	2020	The results indicate that overexpression of HDAC6 causes mitochondrial dysfunction and promotes reactive oxygen species production, leading to degradation of ECM.	Oxygen	105-111	histone deacetylase 6	Mus musculus	44-49
33354282-8	2020	We found that lymphocytes/CD4+ T cells of RRMS patients at the relapse phase significantly produced higher levels of ROS and O2 - compared to patients at the remission phase (P value < 0.001) and healthy controls (P value < 0.001 and P value < 0.05, respectively).	Oxygen	125-127	CD4 molecule	Homo sapiens	26-29
33273499-2	2020	Herein, we present phosphorescent Ir(III) complexes, (btp)2Ir(acac-DM) (Ir-1) and (btp-OH)3Ir (Ir-2), as useful O2 probes for PLIM measurement.	Oxygen	112-114	immune response 1	Mus musculus	72-76
33273499-6	2020	The PLIM images clearly visualized the O2 gradient in hepatic lobules with cellular-level resolution, and the O2 levels were derived based on calibration using cultured cells; the phosphorescence lifetime of Ir-1 gave reasonable O2 levels, whereas Ir-2 exhibited much lower O2 levels.	Oxygen	39-41	immune response 1	Mus musculus	208-212
33273499-6	2020	The PLIM images clearly visualized the O2 gradient in hepatic lobules with cellular-level resolution, and the O2 levels were derived based on calibration using cultured cells; the phosphorescence lifetime of Ir-1 gave reasonable O2 levels, whereas Ir-2 exhibited much lower O2 levels.	Oxygen	110-112	immune response 1	Mus musculus	208-212
33273499-6	2020	The PLIM images clearly visualized the O2 gradient in hepatic lobules with cellular-level resolution, and the O2 levels were derived based on calibration using cultured cells; the phosphorescence lifetime of Ir-1 gave reasonable O2 levels, whereas Ir-2 exhibited much lower O2 levels.	Oxygen	110-112	immune response 1	Mus musculus	208-212
33174311-1	2020	Cycling LiCoO2 to above 4.5 V for higher capacity is enticing; however, hybrid O anion- and Co cation-redox (HACR) at high voltages facilitates intrinsic Oalpha - (alpha < 2) migration, causing oxygen loss, phase collapse, and electrolyte decomposition that severely degrade the battery cyclability.	Oxygen	194-200	glycoprotein hormone subunit alpha 2	Homo sapiens	164-173
31851841-0	2020	Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway.	Oxygen	47-53	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
31911060-2	2020	AIM: To analyse the effect of oxygen fraction reduction (O2 14%, equivalent to 3250 m) on Q-CPR and rescuers" physiological demands.	Oxygen	30-36	cytochrome p450 oxidoreductase	Homo sapiens	92-95
33115265-0	2020	Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.	Oxygen	160-166	signal transducer and activator of transcription 3	Mus musculus	41-46
33115265-0	2020	Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.	Oxygen	160-166	signal transducer and activator of transcription 3	Mus musculus	49-99
33115265-5	2020	Pharmacological inhibition of STAT3 reduced the load of IB4+ cells in the hyaloid vasculature and significantly reduced the formation of pathogenic neovascular tufts during oxygen-induced retinopathy, leading to improved long-term visual outcomes (ie, increased retinal thickness and scotopic b-wave electroretinogram responses).	Oxygen	173-179	signal transducer and activator of transcription 3	Mus musculus	30-35
31852247-1	2020	Background: Prolyl hydroxylase domain proteins (PHD2) is an oxygen sensor that is able to induce hypoxia-inducible factor-alpha (HIF-alpha) degradation under normoxic condition.	Oxygen	60-66	egl-9 family hypoxia inducible factor 1	Homo sapiens	48-52
33153974-4	2020	From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p <= 0.001).	Oxygen	158-164	C-reactive protein	Homo sapiens	30-33
33161250-7	2020	Compound 1 was further confirmed to induce both mRNA and protein levels of Nrf2-dependent antioxidant enzyme genes in BV-2 microglial cells and suppress inflammatory mediators and intracellular reactive oxygen species.	Oxygen	203-209	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
32966875-2	2020	The transcription factor, hypoxia-inducible factor-1 (HIF-1), a heterodimer of HIF-1alpha and HIF-1beta subunits, is the master regulator of oxygen homeostasis in most metazoans.	Oxygen	141-147	LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha-like	Notothenia coriiceps	79-89
32905897-4	2020	Both 2D:4D and the ACE I/D polymorphism are covariates of oxygen metabolism.	Oxygen	58-64	angiotensin I converting enzyme	Homo sapiens	19-22
32895645-10	2020	Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels.	Oxygen	105-111	interleukin 6	Homo sapiens	27-31
32895645-10	2020	Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels.	Oxygen	105-111	interleukin 6 receptor	Homo sapiens	32-38
32895645-10	2020	Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels.	Oxygen	105-111	interleukin 6	Homo sapiens	32-36
32905897-13	2020	Low 2D:4D and ACE II individuals show efficient oxygen metabolism.	Oxygen	48-54	angiotensin I converting enzyme	Homo sapiens	14-17
32208775-7	2020	Incidentally, the changes in blood oxygen levels in pregnant women and developing foetus are accompanied by increase in tolerance due to increased frequency of CD4 + CD25 + FoxP3+ regulatory T cells.	Oxygen	35-41	CD4 molecule	Homo sapiens	160-163
31809610-2	2020	Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histone deacetylase 2 (HDAC2), leading to glucocorticoid resistance.	Oxygen	9-15	histone deacetylase 2	Homo sapiens	184-189
33115855-0	2020	Correction: Hypoxia-Inducible Factor alpha Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer.	Oxygen	110-116	TEK receptor tyrosine kinase	Mus musculus	61-65
32399915-1	2020	HIF-1-mediated adaptation to changes in oxygen availability is a critical aspect of healthy physiology.	Oxygen	40-46	Hypoxia-inducible factor 1	Caenorhabditis elegans	0-5
32896931-10	2020	HIF-1alpha mRNA was positively correlated with the AHI and ODI but negatively correlated with the mean oxygen saturation in patients with OSAHS.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
32656667-6	2020	CAT (0.20 microg/cm2) coating after treatment of polystyrene MCs with oxygen plasma discharge increased the cell recovery rate to 72% at 4 C. Consequently, the combination of oxygen plasma discharge treatment and CAT coating of polystyrene MCs might provide not only adhesion efficiency and growth of MSCs comparable to those on polystyrene MCs without any treatment but also a high cell recover rate of more than 70%.	Oxygen	70-76	catalase	Homo sapiens	0-3
32656667-6	2020	CAT (0.20 microg/cm2) coating after treatment of polystyrene MCs with oxygen plasma discharge increased the cell recovery rate to 72% at 4 C. Consequently, the combination of oxygen plasma discharge treatment and CAT coating of polystyrene MCs might provide not only adhesion efficiency and growth of MSCs comparable to those on polystyrene MCs without any treatment but also a high cell recover rate of more than 70%.	Oxygen	70-76	catalase	Homo sapiens	213-216
32656667-6	2020	CAT (0.20 microg/cm2) coating after treatment of polystyrene MCs with oxygen plasma discharge increased the cell recovery rate to 72% at 4 C. Consequently, the combination of oxygen plasma discharge treatment and CAT coating of polystyrene MCs might provide not only adhesion efficiency and growth of MSCs comparable to those on polystyrene MCs without any treatment but also a high cell recover rate of more than 70%.	Oxygen	175-181	catalase	Homo sapiens	0-3
33380656-1	2020	Background: Tumor cells that have the ability to express vascular endothelial growth factor (VEGF) are more competent to growth and metastasize by the adequate amount of blood and oxygen supply by the blood vessels to the growing mass of cells.	Oxygen	180-186	vascular endothelial growth factor A	Homo sapiens	57-91
33380656-1	2020	Background: Tumor cells that have the ability to express vascular endothelial growth factor (VEGF) are more competent to growth and metastasize by the adequate amount of blood and oxygen supply by the blood vessels to the growing mass of cells.	Oxygen	180-186	vascular endothelial growth factor A	Homo sapiens	93-97
33405317-6	2020	Interestingly, in vitro treatment with VIP restored mitochondrial functions and its efficacy was equal to super oxide dismutase and dimethyl sulfoxide, indicating involvement of superoxide free radical (O2  -) and hydroxyl radical ( OH) in progression of UC.	Oxygen	203-208	vasoactive intestinal polypeptide	Mus musculus	39-42
33098065-2	2020	This study aimed to clarify the underlying mechanism of how CTRP3 regulated mitochondrial functions in hippocampal neuronal cells (HPPNCs) after oxygen-glucose deprivation (OGD)/reoxygenation (R) treatment.	Oxygen	145-151	C1q and TNF related 3	Homo sapiens	60-65
32857872-3	2020	In a normotensive animal experimental model, reducing Na+ intake for two weeks increased renal oxygen consumption that was normalized by mineralocorticoid receptor blockade.	Oxygen	95-101	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	137-163
33258343-0	2020	Jianpi Huazhuo Tiaozhi granules reduce oxidative stress injury in macrophages by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase/reactive oxygen species-nuclear transcription factor kappa B pathway.	Oxygen	157-163	dual oxidase 2	Homo sapiens	96-147
33258343-0	2020	Jianpi Huazhuo Tiaozhi granules reduce oxidative stress injury in macrophages by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase/reactive oxygen species-nuclear transcription factor kappa B pathway.	Oxygen	157-163	nuclear factor kappa B subunit 1	Homo sapiens	172-208
33259010-10	2020	The treatment also restored the mitochondrial biogenesis in the insulin-resistant macrophages by improving ATP production, oxygen consumption, mitochondrial content and potential, while it promoted the expression of mitochondrial biogenesis regulator genes such as TFAM, PGC-1alpha and PPAR-gamma.	Oxygen	123-129	insulin	Homo sapiens	64-71
32893883-2	2020	Nrf2 plays an important role in redox hemostasis of skeletal muscle in response to the increased generation of reactive oxygen species during contraction.	Oxygen	120-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32772955-6	2020	Gene enrichment analysis of the DEGs indicated multiple cellular processes, including oxidative phosphorylation, transcription regulation, mitochondrial regulation, oestrogen signalling pathway, HIF-1 signalling pathway, TNF signalling pathway, were involved in the response to oxygen concentration alterations.	Oxygen	278-284	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-200
33017278-3	2020	The current study a) identified regions of common neural activation to facial and vocal stimuli in 8- to 19-year-old typically-developing adolescents, and b) examined age-related changes in blood-oxygen-level dependent (BOLD) response within these areas.	Oxygen	196-202	renin binding protein	Homo sapiens	167-170
32772955-6	2020	Gene enrichment analysis of the DEGs indicated multiple cellular processes, including oxidative phosphorylation, transcription regulation, mitochondrial regulation, oestrogen signalling pathway, HIF-1 signalling pathway, TNF signalling pathway, were involved in the response to oxygen concentration alterations.	Oxygen	278-284	tumor necrosis factor	Homo sapiens	221-224
33266350-3	2020	In this study using polarographic measurement of oxygen concentration in cellular suspensions we show that H2O2 addition results in O2 release as expected from catalase reaction.	Oxygen	49-55	catalase	Homo sapiens	160-168
33246940-5	2020	shows that NNT activity maintains low ROS levels by means of a fine modulation of mitochondrial oxygen utilization.	Oxygen	96-102	nicotinamide nucleotide transhydrogenase	Homo sapiens	11-14
33330118-1	2020	Salmonella infection associates with tissue hypoxia, while inducible nitric oxide synthase (iNOS), relying for its activity on molecular oxygen, stands as a central host defence measure in murine salmonellosis.	Oxygen	137-143	nitric oxide synthase 2, inducible	Mus musculus	59-90
33330118-1	2020	Salmonella infection associates with tissue hypoxia, while inducible nitric oxide synthase (iNOS), relying for its activity on molecular oxygen, stands as a central host defence measure in murine salmonellosis.	Oxygen	137-143	nitric oxide synthase 2, inducible	Mus musculus	92-96
33324817-6	2020	At the level of molecular composition, the relative content of heteroatom compounds with more oxygen atoms, longer side chain, and higher condensation in the CS2/NMP extract was also higher than that in the methanol extract.	Oxygen	94-100	chorionic somatomammotropin hormone 2	Homo sapiens	158-161
33266350-3	2020	In this study using polarographic measurement of oxygen concentration in cellular suspensions we show that H2O2 addition results in O2 release as expected from catalase reaction.	Oxygen	109-111	catalase	Homo sapiens	160-168
32791187-0	2020	OXYGEN-MEDIATED LUNG injury in mice Lacking the gene for NRF2: Rescue with the cytochrome P4501A-INDUCER, beta-naphthoflavone (BNF), and differential sex-specific effects.	Oxygen	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
33231566-9	2020	Silencing of Nrf2 enhanced the degree of apoptosis of EPCs as well as resulted in the impairment of EPC functions through inducing the promotion of (reactive oxygen species) ROS production.	Oxygen	158-164	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
33283112-0	2020	The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with beta-Thujaplicin through Reactive Oxygen Species-Mediated AKT and p53 Signaling Pathways.	Oxygen	144-150	AKT serine/threonine kinase 1	Homo sapiens	168-171
33214574-6	2020	Mechanistically, our data strongly suggest that reactive oxygen species produced by NQO1-dependent redox cycling of KP372-1 cause robust DNA damage, including DNA breaks.	Oxygen	57-63	NAD(P)H quinone dehydrogenase 1	Homo sapiens	84-88
33282113-3	2020	Hypoxia-inducible factor-1 (HIF-1) is an oxygen-dependent conversion activator that is closely related to the activity of reactive oxygen species (ROS).	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
33282113-3	2020	Hypoxia-inducible factor-1 (HIF-1) is an oxygen-dependent conversion activator that is closely related to the activity of reactive oxygen species (ROS).	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
33184378-6	2020	These effects are initiated by ASA/SA-triggered Akt/mTOR/AMPK-dependent activation of nitric oxide synthase 3 (eNOS), which increases nitric oxide and reactive oxygen species production inducing ER stress response.	Oxygen	160-166	thymoma viral proto-oncogene 1	Mus musculus	48-51
33037038-1	2020	The hypoxia-inducible factors 1alpha and 2alpha (HIF-1alpha and HIF-2alpha) are master regulators of the cellular response to O2.	Oxygen	126-128	hypoxia inducible factor 1 subunit alpha a	Danio rerio	4-47
33037038-1	2020	The hypoxia-inducible factors 1alpha and 2alpha (HIF-1alpha and HIF-2alpha) are master regulators of the cellular response to O2.	Oxygen	126-128	hypoxia inducible factor 1 subunit alpha a	Danio rerio	49-59
33191263-2	2020	The aim of the SARICOR study is to demonstrate that early administration of sarilumab (an IL-6 receptor inhibitor) in hospitalised patients with COVID-19, pulmonary infiltrates and a high IL-6 or D-dimer serum level could reduce the progression of ARDS requiring high-flow nasal oxygen or mechanical ventilation (non-invasive or invasive).	Oxygen	279-285	interleukin 6	Homo sapiens	90-94
33223825-6	2020	In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day.	Oxygen	185-191	CD4 molecule	Homo sapiens	145-148
33223825-6	2020	In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day.	Oxygen	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33262737-0	2020	Effects of Apolipoprotein E Polymorphism on Cerebral Oxygen Saturation After Traumatic Brain Injury.	Oxygen	53-59	apolipoprotein E	Homo sapiens	11-27
33262737-1	2020	Objective: To investigate the effects of the apolipoprotein E gene (APOE) on the cerebral oxygen saturation of patients after traumatic brain injury (TBI).	Oxygen	90-96	apolipoprotein E	Homo sapiens	45-61
33262737-1	2020	Objective: To investigate the effects of the apolipoprotein E gene (APOE) on the cerebral oxygen saturation of patients after traumatic brain injury (TBI).	Oxygen	90-96	apolipoprotein E	Homo sapiens	68-72
33518858-5	2020	The developed QSAR models identified number of sp2 hybridized Oxygen atoms within seven bonds from aromatic Carbon atoms, the presence of Carbon and Nitrogen atoms at a topological distance of 3 and other interrelations of atom pairs as important pharmacophoric features.	Oxygen	62-68	Sp2 transcription factor	Homo sapiens	47-50
32791852-5	2021	This review analyses the roles of key oxygen-sensing pathways in cellular and systemic regulation of iron homeostasis; specifically, the prolyl hydroxylase domain (PHD)/ hypoxia-inducible factor (HIF) and the KEAP1/NRF2 pathways, which mediate tissue adaptation to low and high oxygen, respectively.	Oxygen	38-44	kelch like ECH associated protein 1	Homo sapiens	209-214
33124818-0	2020	Anisotropic Strain Tuning of L10 Ternary Nanoparticles for Oxygen Reduction.	Oxygen	59-65	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	29-32
33124818-2	2020	Here, we present our new study on using an eigenforce model to predict and experiments to verify the strain-induced catalysis enhancement of the oxygen reduction reaction (ORR) in the presence of L10-CoMPt NPs (M = Mn, Fe, Ni, Cu, Ni).	Oxygen	145-151	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	196-199
32791852-5	2021	This review analyses the roles of key oxygen-sensing pathways in cellular and systemic regulation of iron homeostasis; specifically, the prolyl hydroxylase domain (PHD)/ hypoxia-inducible factor (HIF) and the KEAP1/NRF2 pathways, which mediate tissue adaptation to low and high oxygen, respectively.	Oxygen	38-44	NFE2 like bZIP transcription factor 2	Homo sapiens	215-219
33525211-11	2020	CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r=0.56 and 0.61, respectively; p<0.01).	Oxygen	91-97	C-reactive protein	Homo sapiens	0-3
33240803-3	2020	In this study, we designed a lymphoma tissue factor-targeted "O2-evolving" strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma.	Oxygen	62-64	catalase	Homo sapiens	103-111
33205000-8	2020	When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP.	Oxygen	47-53	interleukin 6	Homo sapiens	205-209
33205000-8	2020	When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP.	Oxygen	47-53	C-reactive protein	Homo sapiens	230-233
33182844-4	2020	Findings show that androgen receptor (AR) modulation, by use of androgens and antiandrogens, has a significant impact on cell survival, especially in hypoxic conditions (4% O2).	Oxygen	173-175	androgen receptor	Homo sapiens	19-36
33182844-4	2020	Findings show that androgen receptor (AR) modulation, by use of androgens and antiandrogens, has a significant impact on cell survival, especially in hypoxic conditions (4% O2).	Oxygen	173-175	androgen receptor	Homo sapiens	38-40
33200733-5	2021	RESULTS: CTD-PAH had higher rest heart rate (HR@Rest) and lower rest oxygen uptake/HR (VO2/HR@Rest) than IPAH.	Oxygen	69-75	CTD	Homo sapiens	9-12
32871175-12	2020	This study demonstrated, for the first time, a sudden increase in reactive oxygen species and effects of the downstream cascades play core roles in the development of TS.	Oxygen	75-81	thymidylate synthetase	Rattus norvegicus	167-169
33106407-6	2020	Both vaso-obliteration (VO) and NV were significantly inhibited in an oxygen-induced retinopathy (OIR) model following intravitreal injection of the CITED2 peptide.	Oxygen	70-76	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	149-155
32871175-2	2020	The relationship between TS and reactive oxygen species has received increasing attention over in recent years.	Oxygen	41-47	thymidylate synthetase	Rattus norvegicus	25-27
33174947-3	2020	The present study aimed to analyze the effects of different levels of physical activity, classified by the Maximal oxygen consumption (VO2 max) values, on the telomere length of memory Cluster of differentiation (CD) CD4+(CD45ROneg and CD45RO+), effector CD8+CD28neg, and CD8+CD28+ T cells in aged individuals.	Oxygen	115-121	CD4 molecule	Homo sapiens	217-220
33158991-7	2021	Consistently, our findings indicated that BAMBI may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome.	Oxygen	66-72	BMP and activin membrane-bound inhibitor	Mus musculus	42-47
32768854-4	2020	The PFRs enabled an efficient transfer electron to both cobalt atom and O2, facilitating the recycle of Co(III)/Co(II), and thereby leaded to an excellent catalytic performance.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	104-111
32768854-4	2020	The PFRs enabled an efficient transfer electron to both cobalt atom and O2, facilitating the recycle of Co(III)/Co(II), and thereby leaded to an excellent catalytic performance.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
32886745-0	2020	p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.	Oxygen	85-91	tumor protein p53	Homo sapiens	0-3
33153240-8	2020	Moreover, peroxisomes were also found to be activated in response to melatonin treatment, causing the activation of catalase; together with Nrf2 signaling, peroxisomes synergistically prevented the generation of reactive oxygen species and enhanced oocyte quality.	Oxygen	221-227	catalase	Homo sapiens	116-124
33153240-8	2020	Moreover, peroxisomes were also found to be activated in response to melatonin treatment, causing the activation of catalase; together with Nrf2 signaling, peroxisomes synergistically prevented the generation of reactive oxygen species and enhanced oocyte quality.	Oxygen	221-227	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
32886745-4	2020	Analysis of mouse and human oncogene-expressing wild-type and p53-deficient cells in physiological oxygen conditions revealed that p53 loss concurrently impacts numerous distinct cellular processes, including apoptosis, genome stabilization, DNA repair, metabolism, migration, and invasion.	Oxygen	99-105	tumor protein p53	Homo sapiens	131-134
33099588-7	2020	Notably, the BSA-MnO2 nanozyme, with intrinsic catalase (CAT)-like activity, catalyzed endogenous H2O2 for oxygen generation to overcome tumor hypoxia and enhance PDT, thereby leading to more efficient therapeutic effects in combination with OCNC-elevated PTT.	Oxygen	107-113	catalase	Homo sapiens	47-55
33099588-7	2020	Notably, the BSA-MnO2 nanozyme, with intrinsic catalase (CAT)-like activity, catalyzed endogenous H2O2 for oxygen generation to overcome tumor hypoxia and enhance PDT, thereby leading to more efficient therapeutic effects in combination with OCNC-elevated PTT.	Oxygen	107-113	catalase	Homo sapiens	57-60
32886745-4	2020	Analysis of mouse and human oncogene-expressing wild-type and p53-deficient cells in physiological oxygen conditions revealed that p53 loss concurrently impacts numerous distinct cellular processes, including apoptosis, genome stabilization, DNA repair, metabolism, migration, and invasion.	Oxygen	99-105	tumor protein p53	Homo sapiens	62-65
33128527-8	2020	Conclusions DTS caused a significant (p<0.001) reduction in p50 values indicating a shift of the oxygen- haemoglobin dissociation curve to the left in all the samples compared with control, suggesting that the administration of DTS could result in decrease in oxygen supply to tissues.	Oxygen	97-103	nuclear factor kappa B subunit 1	Homo sapiens	60-63
33128527-8	2020	Conclusions DTS caused a significant (p<0.001) reduction in p50 values indicating a shift of the oxygen- haemoglobin dissociation curve to the left in all the samples compared with control, suggesting that the administration of DTS could result in decrease in oxygen supply to tissues.	Oxygen	260-266	nuclear factor kappa B subunit 1	Homo sapiens	60-63
33304789-2	2020	Catalase, an antioxidant enzyme, is capable of decomposing endogenous hydrogen peroxide (H2O2) into oxygen for tumor reoxygenation, but suffered from in vivo instability and limited delivery to deep interior hypoxic regions in tumor.	Oxygen	100-106	catalase	Homo sapiens	0-8
33079442-1	2020	New blue (DBA-SAB) and deep-blue (TDBA-SAF) thermally activated delayed fluorescence (TADF) emitters are synthesized for blue-emitting organic-light emitting diodes (OLEDs) by incorporating spiro-biacridine and spiro-acridine fluorene donor units with an oxygen-bridged boron acceptor unit, respectively.	Oxygen	255-261	FAS antisense RNA 1	Homo sapiens	39-42
31927141-9	2020	Conversely, if excessive fuel flux surpasses the capacity of the respiratory chain, threatening the release of damaging reactive oxygen species (ROS), the polarity of the cytochrome c redox system is reversed, resulting in the chemical reduction of the PKCdelta CRD, restoration of the RING-finger, refolding of PKCdelta into the inactive, globular form, and curtailment of PDHC output, thereby constraining the respiratory capacity within safe margins.	Oxygen	129-135	cytochrome c, somatic	Homo sapiens	171-183
32938216-5	2020	Consequently, choline ameliorated Ang II (angiotensin II)-induced increases in NOX (NAD[P]H oxidase) expression and the mitochondrial reactive oxygen species level, thereby attenuating Ang II-induced VSMC phenotypic switching, proliferation, and migration, presumably via M3AchR (type 3 muscarinic acetylcholine receptors).	Oxygen	143-149	angiotensinogen	Rattus norvegicus	42-56
31931659-12	2020	Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence activation and myofibroblast differentiation in distinct cellular subpopulations.Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG: 5-dodecanoylaminofluorescein Di-beta-D-Galactopyranoside; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; Ctl: control; DAPI: 4",6-diamidino-2-phenylindole, dilactate; ECM: extracellular matrix; GSH: L-glutathione reduced; H2O2: hydrogen peroxide; HLF: adult human lung fibroblasts; Ho: Hoechst 33342 (2"-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2.5"-bi-1H-benzimidazole); HSC: hepatic stellate cells; LY: LY294002; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTORC1/2: mechanistic target of rapamycin kinase complex 1/2; N: normal growth medium; NAC: N-acetyl-L-cysteine; PBS: phosphate-buffered saline; PDGFA: platelet derived growth factor subunit A; PRKCA/PKCalpha: protein kinase C alpha; PtdIns3K: class III phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog; R: rapamycin; RICTOR: RPTOR independent companion of MTOR complex 2; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; SA-GLB1/beta-gal: senescence-associated galactosidase beta 1; SGK1: serum/glucocorticoid regulated kinase 1; shRNA: short hairpin RNA; siCtl: control siRNA; siRNA: small interfering RNA; SQSTM1: sequestosome 1; SS: serum-free (serum starvation) medium; TP53: tumor protein p53; TUBA: tubulin alpha; V: vehicle.	Oxygen	1437-1443	mechanistic target of rapamycin kinase	Homo sapiens	62-66
31964216-6	2020	In HSPA9-deficient cells, the level of peroxisomal reactive oxygen species (ROS) increased, while inhibition of ROS blocked pexophagy in HeLa and SH-SY5Y cells.	Oxygen	60-66	heat shock protein family A (Hsp70) member 9	Homo sapiens	3-8
32433558-5	2020	In contrast, oxygen, and nutrient deprivation promote high amounts of TRAILR2 expression in TRAIL-hypersensitive cells in inner spheroid layers.	Oxygen	13-19	TNF superfamily member 10	Homo sapiens	70-75
32768687-0	2020	In vivo survival strategies for cellular adaptation to hypoxia: HIF1alpha-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-73
32311288-0	2020	Galectin-3 mediates high-glucose-induced cardiomyocyte injury by NADPH oxidase/reactive oxygen species pathway.	Oxygen	88-94	galectin 3	Rattus norvegicus	0-10
31939057-7	2020	Severe diminution of the antioxidant enzymes like superoxide dismutase, catalase, and GPx increases the tissue damage by reactive oxygen and nitrogen species.	Oxygen	130-136	catalase	Homo sapiens	72-80
32885495-4	2020	Acute exposure of myotubes to IL-6 increased the mitochondrial reactive oxygen species (mtROS) production and oxygen consumption rates (JO2 ) in a manner that was dependent on activation of the JAK/STAT pathway.	Oxygen	72-78	interleukin 6	Homo sapiens	30-34
32645597-7	2020	In the system containing 10 mg L-1 As(III) and 1.0 g L-1 Fe-Mn nodules, the maximum oxidation capacity of As(III) reached 3.22, 3.48 and 3.71 mg g-1, and the corresponding As(III,V) adsorption capacity reached 2.49, 2.40, and 2.39 mg g-1 in nitrogen, air and oxygen atmosphere, respectively.	Oxygen	259-265	L1 cell adhesion molecule	Homo sapiens	31-34
32645597-7	2020	In the system containing 10 mg L-1 As(III) and 1.0 g L-1 Fe-Mn nodules, the maximum oxidation capacity of As(III) reached 3.22, 3.48 and 3.71 mg g-1, and the corresponding As(III,V) adsorption capacity reached 2.49, 2.40, and 2.39 mg g-1 in nitrogen, air and oxygen atmosphere, respectively.	Oxygen	259-265	L1 cell adhesion molecule	Homo sapiens	53-56
32593823-5	2020	Integrating the trapping experiments and electrochemical analysis, we found the oxygen vacancy on B-TiO2-x capturing the electrons to promote the separation of photogenerated charges, meanwhile the Co(II) in the composite decomposed hydrogen peroxide (H2O2) to produce more  OH radical.	Oxygen	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32705548-6	2020	Design Expert 12.0.8.0 software has been used to design mathematical model to obtain optimum condition (14 V and 47 min) at pH of 7.35, which provides experimental removal efficiency (75.6% chemical oxygen demand, 78.7% total dissolved solids, 93.4% turbidity, and 63.2% chloride) with minimal electrode consumption of 1.38 mg L-1.	Oxygen	199-205	L1 cell adhesion molecule	Homo sapiens	327-330
32315657-5	2020	We verified that HIF-1alpha protein is more strongly expressed in keloid specimens compared to normal skin (p=0.035) and that hypoxia (1% O2) leads to increased collagen, especially in the extracellular compartment.	Oxygen	138-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
32561280-4	2020	The hydrogel could enhance the deposition of minerals and the activity of alkaline phosphatase (ALP), in large part attributable to the oxygen and amine-containing functional groups of GO and CS.	Oxygen	136-142	alkaline phosphatase, placental	Homo sapiens	74-94
32561280-4	2020	The hydrogel could enhance the deposition of minerals and the activity of alkaline phosphatase (ALP), in large part attributable to the oxygen and amine-containing functional groups of GO and CS.	Oxygen	136-142	alkaline phosphatase, placental	Homo sapiens	96-99
31960418-14	2020	Compared with BM-MSC-exo, injection of MIF-BM-MSC-exo was associated with enhanced heart function, reduced heart remodeling, less cardiomyocyte mitochondrial fragmentation, reactive oxygen species generation, and apoptosis.	Oxygen	182-188	macrophage migration inhibitory factor	Rattus norvegicus	39-42
33052996-3	2020	Indeed, transition metal ions such as Cu(ii) can generate Reactive Oxygen Species (ROS) via O2 Fenton-like reduction, catalyzed by Cu(ii) coordinated to the Amyloid beta (Abeta) peptide.	Oxygen	92-94	amyloid beta precursor protein	Homo sapiens	157-169
32512491-7	2020	We theorized that the Angiotensin II clearance by the red blood cells could trigger the release of its oxygen content in the bloodstream.	Oxygen	103-109	angiotensinogen	Homo sapiens	22-36
32761814-1	2020	KEY POINTS: A fall in oxygen supply releases a remedial response that is otherwise prevented when the oxygen supply is sufficient; for example, the remedial function of HIF-1alpha is released when oxygen levels fall.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
32761814-1	2020	KEY POINTS: A fall in oxygen supply releases a remedial response that is otherwise prevented when the oxygen supply is sufficient; for example, the remedial function of HIF-1alpha is released when oxygen levels fall.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
32761814-1	2020	KEY POINTS: A fall in oxygen supply releases a remedial response that is otherwise prevented when the oxygen supply is sufficient; for example, the remedial function of HIF-1alpha is released when oxygen levels fall.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
33052996-3	2020	Indeed, transition metal ions such as Cu(ii) can generate Reactive Oxygen Species (ROS) via O2 Fenton-like reduction, catalyzed by Cu(ii) coordinated to the Amyloid beta (Abeta) peptide.	Oxygen	92-94	amyloid beta precursor protein	Homo sapiens	171-176
32805675-7	2020	Antioxidants such as superoxide dismutase (SOD) and Tiron not only scavenged O2- production, but also markedly rescued SLC7A11 down-regulation, GSH depletion, GPx4 inactivation, iron accumulation, LPO, and ferroptosis.	Oxygen	77-80	superoxide dismutase 1	Homo sapiens	21-41
32761664-3	2020	We report that physiologically relevant oxygen concentration (5% O2 , Physioxia), an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T (proT) cells in serum-free and feeder-free culture system.	Oxygen	40-46	CD34 molecule	Homo sapiens	162-166
32761664-3	2020	We report that physiologically relevant oxygen concentration (5% O2 , Physioxia), an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T (proT) cells in serum-free and feeder-free culture system.	Oxygen	65-67	CD34 molecule	Homo sapiens	162-166
32924690-0	2020	The sp3/sp2 carbon ratio as a modulator of in vivo and in vitro toxicity of the chemically purified detonation-synthesized nanodiamond via the reactive oxygen species generation.	Oxygen	152-158	Sp3 transcription factor	Rattus norvegicus	4-11
32805675-7	2020	Antioxidants such as superoxide dismutase (SOD) and Tiron not only scavenged O2- production, but also markedly rescued SLC7A11 down-regulation, GSH depletion, GPx4 inactivation, iron accumulation, LPO, and ferroptosis.	Oxygen	77-80	superoxide dismutase 1	Homo sapiens	43-46
33128166-0	2021	The inflammation and reactive oxygen species regulated by Nrf2 and NF-kappaB signaling pathways in 630-nm light-emitting diode irradiation treated THP-1 monocytes/macrophages.	Oxygen	30-36	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
33128166-0	2021	The inflammation and reactive oxygen species regulated by Nrf2 and NF-kappaB signaling pathways in 630-nm light-emitting diode irradiation treated THP-1 monocytes/macrophages.	Oxygen	30-36	nuclear factor kappa B subunit 1	Homo sapiens	67-76
33128166-0	2021	The inflammation and reactive oxygen species regulated by Nrf2 and NF-kappaB signaling pathways in 630-nm light-emitting diode irradiation treated THP-1 monocytes/macrophages.	Oxygen	30-36	GLI family zinc finger 2	Homo sapiens	147-152
33122751-2	2020	Tumor hypoxia, characterized by low oxygen concentrations in the microenvironment of most solid tumors has been shown to accelerate FN assembly in fibroblasts and cancer-associated fibroblasts, cell types that produce abundant amounts of FN protein.	Oxygen	36-42	fibronectin 1	Homo sapiens	132-134
33143240-3	2020	The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO.	Oxygen	64-70	erythropoietin	Homo sapiens	18-21
33143240-3	2020	The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO.	Oxygen	112-118	erythropoietin	Homo sapiens	18-21
33195943-8	2020	When the Pds sites in both catalysts were equivalent in terms of their specific activities, the activity difference between Pd/CZ and Pd/Al2O3 corresponded to the contribution from Pdb, where oxygen storage/release to/from CZ played a key role.	Oxygen	192-198	PDB1	Homo sapiens	181-184
33122751-2	2020	Tumor hypoxia, characterized by low oxygen concentrations in the microenvironment of most solid tumors has been shown to accelerate FN assembly in fibroblasts and cancer-associated fibroblasts, cell types that produce abundant amounts of FN protein.	Oxygen	36-42	fibronectin 1	Homo sapiens	238-240
33109604-6	2020	We uncovered deficits in insulin secretion, partly due to reduced mitochondrial oxygen consumption rate, glucose-stimulated Ca2+ flux, and reduced insulin content associated with loss of eIF4E, the mRNA 5"-cap binding protein of the initiation complex and binding partner of eIF4G1.	Oxygen	80-86	insulin	Homo sapiens	25-32
33192319-10	2020	Our data show increased claudin-5 and occludin expression in oxygen and glucose (OGD)-deprived murine brain capillary cerebellar endothelial cells (cerebEND) after STVNa treatment.	Oxygen	61-67	occludin	Mus musculus	38-46
33120873-2	2020	They are closely interconnected in the catabolism of reactive oxygen species because one product of SOD reaction (hydrogen peroxide) is the main substrate of CAT reaction finally leading to harmless products (i.e., molecular oxygen and water).	Oxygen	62-68	superoxide dismutase 1	Homo sapiens	100-103
33126773-0	2020	Pulsed Electromagnetic Fields Stimulate HIF-1alpha-Independent VEGF Release in 1321N1 Human Astrocytes Protecting Neuron-Like SH-SY5Y Cells from Oxygen-Glucose Deprivation.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Oxygen	113-115	superoxide dismutase 1	Homo sapiens	190-193
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Oxygen	174-176	superoxide dismutase 1	Homo sapiens	190-193
32938724-0	2020	Hypoxia-Inducible Factor alpha Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer.	Oxygen	98-104	TEK receptor tyrosine kinase	Mus musculus	49-53
33195318-4	2020	Inhibiting CRS by agents suppressing IL-6 may relieve symptoms, shorten the hospital stay and reduce the need for oxygen therapy.	Oxygen	114-120	interleukin 6	Homo sapiens	37-41
33113858-2	2020	Several mechanisms regulate the cellular response to oxygen including the prolyl hydroxylase domain (PHD)/factor inhibiting HIF (FIH)-hypoxia inducible factor (HIF) pathway, cysteamine (2-aminoethanethiol) dioxygenase (ADO) system, and the lysine-specific demethylases (KDM) 5A and KDM6A.	Oxygen	53-59	lysine demethylase 6A	Homo sapiens	282-287
33118488-2	2020	The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	163-197
33118488-2	2020	The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	199-203
33118488-2	2020	The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	83-89	vascular endothelial growth factor A	Homo sapiens	163-197
33118488-2	2020	The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	83-89	vascular endothelial growth factor A	Homo sapiens	199-203
33083921-9	2021	CONCLUSIONS: Our data suggest that in premenopausal women with anovulation, a proinflammatory condition mediated by IL-6 is associated with lower oxygen levels during sleep.	Oxygen	146-152	interleukin 6	Homo sapiens	116-120
33104519-3	2020	Here, we examined the dynamic change of the tumor suppressor p16INK4a in cells of skeletal muscle among young men following 60-min of aerobic cycling at 70% maximal oxygen consumption (VO2max).	Oxygen	165-171	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-69
33099578-7	2020	In HK-2 and mesangial cell cultures, high glucose, fatty acid, and TNF-alpha combination was able to activate the lipogenic pathways, increase oxidative stress, promote mitochondrial fission, and activate the pro-apoptotic pathway, all of which could be attenuated by an inhibitor that depleted reactive oxygen species.	Oxygen	304-310	tumor necrosis factor	Mus musculus	67-76
33144915-5	2020	Both catalase (43%) and acetylated cytochrome c (19%) significantly decreased oxygen consumption that had been stimulated by doxorubicin; furthermore, extracellular hydrogen peroxide production was increased from undetectable control levels to 1.30 +- 0.02 nmol/min/107 myocytes (n = 4, P < 0.01) in the presence of 400 muM doxorubicin.	Oxygen	78-84	catalase	Rattus norvegicus	5-13
33082354-10	2020	Lipid raft/caveolae disruptors (methyl-beta-cyclodextrin (MCD) and Nystatin) and Ang II stimulation variably increased O2- generation and phosphorylation of MLC20, Ezrin-Radixin-Moesin (ERM) and p53 but not ERK1/2, effects recapitulated in Cav-1 silenced (siRNA) VSMCs.	Oxygen	119-121	angiotensinogen	Homo sapiens	81-87
32663129-2	2020	The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: alpha (oxygen sensitive) and beta.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-91
32663129-2	2020	The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: alpha (oxygen sensitive) and beta.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98
32663129-2	2020	The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: alpha (oxygen sensitive) and beta.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-91
32663129-2	2020	The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: alpha (oxygen sensitive) and beta.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98
32791151-10	2020	Hyperbaric oxygen promoted the proliferation, migration and ROS production, as well as the expression of SDF-1 and VEGFA in HSF.	Oxygen	11-17	interleukin 6	Homo sapiens	124-127
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	interleukin 6	Homo sapiens	167-170
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	interleukin 6	Homo sapiens	259-262
33101583-0	2020	Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway.	Oxygen	9-15	AKT serine/threonine kinase 1	Homo sapiens	124-127
32996507-3	2020	For the eight concerted routes, the cooperative bimetallic route in which the middle carbon atom is attacked by the nucleophilic oxygen atom (route VI-m) was calculated to be the most favorable, and among the three catalysts examined H2O-CoIII-OTs was found to be the most active, due to the strong hydrogen bonding between the nucleophilic H2O and the ring oxygen atom in the epoxides as well as the extra pi-pi stacking interaction.	Oxygen	129-135	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	238-243
32996507-3	2020	For the eight concerted routes, the cooperative bimetallic route in which the middle carbon atom is attacked by the nucleophilic oxygen atom (route VI-m) was calculated to be the most favorable, and among the three catalysts examined H2O-CoIII-OTs was found to be the most active, due to the strong hydrogen bonding between the nucleophilic H2O and the ring oxygen atom in the epoxides as well as the extra pi-pi stacking interaction.	Oxygen	358-364	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	238-243
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	vascular endothelial growth factor A	Homo sapiens	153-157
33122967-7	2020	We found that high oxygen concentrations increased IL-6 and biomarkers of organ damage levels in septic animals, although no relevant histopathological lung or brain damage was observed.	Oxygen	19-25	interleukin 6	Rattus norvegicus	51-55
33122967-8	2020	Healthy rats had an increase in IL-6 and aspartate aminotransferase at high oxygen concentration.	Oxygen	76-82	interleukin 6	Rattus norvegicus	32-36
33007157-8	2020	The introduced CAT catalyzed the decomposition of H2O2 to O2, leading to an enhancement of the photocurrent response.	Oxygen	52-54	catalase	Homo sapiens	15-18
33028529-3	2020	Here, we found that DSBs in oxygen/glucose-deprived (OGD) neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.	Oxygen	28-34	tumor protein p53	Homo sapiens	142-145
33037242-1	2020	Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and critically determines cellular oxygen availability.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	51-54
33037242-1	2020	Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and critically determines cellular oxygen availability.	Oxygen	114-120	nuclear factor kappa B subunit 1	Homo sapiens	51-54
33037242-6	2020	For comparison, right shift of ODC after VO2max test, representing the maximal physiological range to release oxygen to the tissue, indicated a p50 difference of up to 10 mmHg.	Oxygen	110-116	nuclear factor kappa B subunit 1	Homo sapiens	144-147
33037242-7	2020	P50 at rest differs significantly between women and men, with women showing lower Hb-O2 affinity that is determined by higher 2,3-BPG and BPGM levels.	Oxygen	85-87	nuclear factor kappa B subunit 1	Homo sapiens	0-3
33028901-1	2020	Alcohol dehydrogenase (ADH) and pyruvate decarboxylase (PDC) are key to the establishment of the fermentative metabolism in plants during oxygen shortage.	Oxygen	138-144	pyruvate decarboxylase-2	Arabidopsis thaliana	32-54
33021853-5	2020	In addition, PA altered intracellular redox status and induced reactive oxygen species that were reduced by C3G via the redox-sensitive Nrf2 signalling.	Oxygen	72-78	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
32960574-1	2020	The affinity of AtO+ for around 20 model ligands (L), carrying functionalized oxygen, sulfur, and nitrogen atoms, has been assessed through a combined experimental and theoretical methodology.	Oxygen	78-84	splicing factor-like protein	Arabidopsis thaliana	16-19
32757375-1	2020	Evaluating the availability of molecular oxygen (O2 ) and energy of excited states in the retinal binding site of rhodopsin is a crucial challenging first step to understand photosensitizing reactions in wild-type (WT) and mutant rhodopsins by absorbing visible light.	Oxygen	41-47	rhodopsin	Homo sapiens	114-123
32757375-1	2020	Evaluating the availability of molecular oxygen (O2 ) and energy of excited states in the retinal binding site of rhodopsin is a crucial challenging first step to understand photosensitizing reactions in wild-type (WT) and mutant rhodopsins by absorbing visible light.	Oxygen	49-51	rhodopsin	Homo sapiens	114-123
33017851-1	2020	The study aimed to assess the relationship between peak oxygen uptake, ventilatory thresholds and maximal fat oxidation with ultra trail male and female performance.	Oxygen	56-62	TNF superfamily member 10	Homo sapiens	131-136
32960574-4	2020	The quantum mechanical calculations definitively ruled out any rationale based on either the metallic character of astatine or its guessed softness; the favored interactions all involve specifically the oxygen atom of AtO+, leading to the formation of covalent O-S or O-C single bonds.	Oxygen	203-209	splicing factor-like protein	Arabidopsis thaliana	218-221
32960574-4	2020	The quantum mechanical calculations definitively ruled out any rationale based on either the metallic character of astatine or its guessed softness; the favored interactions all involve specifically the oxygen atom of AtO+, leading to the formation of covalent O-S or O-C single bonds.	Oxygen	203-209	splicing factor-like protein	Arabidopsis thaliana	220-221
32960574-4	2020	The quantum mechanical calculations definitively ruled out any rationale based on either the metallic character of astatine or its guessed softness; the favored interactions all involve specifically the oxygen atom of AtO+, leading to the formation of covalent O-S or O-C single bonds.	Oxygen	203-209	splicing factor-like protein	Arabidopsis thaliana	261-262
33020411-1	2020	Intermittent hypoxia, defined as alternating bouts of breathing hypoxic and normoxic air, has the potential to improve oxygen-carrying capacity through an erythropoietin-mediated increase in hemoglobin mass.	Oxygen	119-125	erythropoietin	Homo sapiens	155-169
33020438-4	2020	The static contact angle measurement suggested that beta-CD modification increased the hydrophobicity of the CN photocatalyst as well as its affinity to oxygen gas, leading to an increase in H2O2 production.	Oxygen	153-159	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	52-59
33009389-4	2020	PQM-1 functions as a metabolic regulator by controlling oxygen consumption rates, suppressing hypoxic glycogen levels, and inhibiting the expression of the sorbitol dehydrogenase-1 SODH-1, a crucial sugar metabolism enzyme.	Oxygen	56-62	Zinc finger transcription factor pqm-1	Caenorhabditis elegans	0-5
32960070-2	2020	The synthesis features ether cross-links between the phenolic oxygen of Tyr6 and the beta position of Tyr3 and the phenolic oxygen of Tyr3 and the beta position of Hpp1 in the unique 17- and 14-membered bicyclic structure of asperipin-2a, respectively.	Oxygen	62-68	familial progressive hyperpigmentation 1	Homo sapiens	164-168
32960070-2	2020	The synthesis features ether cross-links between the phenolic oxygen of Tyr6 and the beta position of Tyr3 and the phenolic oxygen of Tyr3 and the beta position of Hpp1 in the unique 17- and 14-membered bicyclic structure of asperipin-2a, respectively.	Oxygen	124-130	familial progressive hyperpigmentation 1	Homo sapiens	164-168
33009389-5	2020	PQM-1 promotes hypoxic fat metabolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis.	Oxygen	109-115	Zinc finger transcription factor pqm-1	Caenorhabditis elegans	0-5
33004691-7	2020	In oxygen-induced retinopathy, hyperglycemia/hypoinsulinemia decreased liver IGF1 expression (P < 0.0001); rh-IGF1 treatment improved normal vascular regrowth (P = 0.027) and reduced neovascularization (P < 0.0001).CONCLUSIONIn extremely preterm infants, high early postnatal plasma glucose levels and signs of insulin insensitivity were associated with lower IGF1 levels and increased ROP severity.	Oxygen	3-9	insulin like growth factor 1	Homo sapiens	77-81
33089038-5	2020	Among the 72 patients receiving supplemental oxygen without mechanical ventilation, severity of condition on the NEWS2 scale scores fell from 5 to 2 (P<0.001), C reactive protein levels fell from 95 to 14 mg/L (P<0.001), and lymphocyte counts rose from 900 to 1000/uL (P=0.036).	Oxygen	45-51	C-reactive protein	Homo sapiens	160-178
33004691-7	2020	In oxygen-induced retinopathy, hyperglycemia/hypoinsulinemia decreased liver IGF1 expression (P < 0.0001); rh-IGF1 treatment improved normal vascular regrowth (P = 0.027) and reduced neovascularization (P < 0.0001).CONCLUSIONIn extremely preterm infants, high early postnatal plasma glucose levels and signs of insulin insensitivity were associated with lower IGF1 levels and increased ROP severity.	Oxygen	3-9	insulin	Homo sapiens	49-56
33004691-7	2020	In oxygen-induced retinopathy, hyperglycemia/hypoinsulinemia decreased liver IGF1 expression (P < 0.0001); rh-IGF1 treatment improved normal vascular regrowth (P = 0.027) and reduced neovascularization (P < 0.0001).CONCLUSIONIn extremely preterm infants, high early postnatal plasma glucose levels and signs of insulin insensitivity were associated with lower IGF1 levels and increased ROP severity.	Oxygen	3-9	insulin like growth factor 1	Homo sapiens	110-114
32562941-4	2020	Those pPt-PEG NPs are able to produce reactive oxygen species (ROS) by triggering water decomposition under electric field, independent of O2 and H2O2 contents in the tumor.	Oxygen	139-141	tachykinin precursor 1	Homo sapiens	6-9
32846625-5	2020	Generation of intracellular reactive oxygen species during adipogenesis was markedly decreased by BMH < 1 kDa treatment, which is attributed to the up-regulation of heme oxygenase-1 (HO-1) through Nrf2 translocation into the nucleus.	Oxygen	37-43	heme oxygenase 1	Mus musculus	183-187
32592722-0	2020	TNF-alpha inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.	Oxygen	56-62	tumor necrosis factor	Rattus norvegicus	0-9
33202209-4	2020	The suppressed expression of BNIP3 caused inhibition of oxygen consumption and stimulated production of the mitochondrial reactive oxygen species, suggesting the role of BNIP3 in induction of mitochondrial dysfunction and its potential involvement in regulation of cell death.	Oxygen	56-62	BCL2 interacting protein 3	Homo sapiens	29-34
33202209-4	2020	The suppressed expression of BNIP3 caused inhibition of oxygen consumption and stimulated production of the mitochondrial reactive oxygen species, suggesting the role of BNIP3 in induction of mitochondrial dysfunction and its potential involvement in regulation of cell death.	Oxygen	131-137	BCL2 interacting protein 3	Homo sapiens	29-34
32388677-4	2020	Mechanistically, in the GC cells under the 5-FU treatment, reactive oxygen species is accumulated and then induces the activation of HIF1alpha signaling to drive the expression of high-mobility group box 1, which leads to more macrophage"s infiltration into GC tumor.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-142
32505950-7	2020	However, these new adsorbed ammonia species, highly related to the sulfate from the Ce2(SO4)3, were inert and did not react with the adsorbed or gaseous NO species at 200-300  C. The abundant surface lattice oxygen from CeO2 microcrystals improved the catalytic oxidation capacity of the RMcn and RMcan.	Oxygen	208-214	carboxylesterase 2	Homo sapiens	84-93
32801061-1	2020	Hypoxia-inducible factor-1alpha (HIF-1alpha) is the oxygen sensitive subunit of HIF1 transcription factor.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
32801061-1	2020	Hypoxia-inducible factor-1alpha (HIF-1alpha) is the oxygen sensitive subunit of HIF1 transcription factor.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
32801061-1	2020	Hypoxia-inducible factor-1alpha (HIF-1alpha) is the oxygen sensitive subunit of HIF1 transcription factor.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-84
32846625-5	2020	Generation of intracellular reactive oxygen species during adipogenesis was markedly decreased by BMH < 1 kDa treatment, which is attributed to the up-regulation of heme oxygenase-1 (HO-1) through Nrf2 translocation into the nucleus.	Oxygen	37-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
32945393-7	2020	The present study, based on bioinformatics analysis and experimental studies in vivo and in vitro, demonstrated that Hpa enhanced the crosstalk between TNBC cells and PLT to increase the supply of oxygen and nutrients, while also conferring tolerance of TNBC cells to oxygen and nutrient shortage, both of which are important for overcoming the stress of hypoxia and nutritional deprivation in the tumor microenvironment, thereby promoting malignant progression, including growth, angiogenesis and metastasis in TNBC.	Oxygen	197-203	heparanase	Homo sapiens	117-120
32903101-8	2020	ASK1 was not activated by IL1beta in cardiomyocytes and activation in perfused hearts was due to increased reactive oxygen species.	Oxygen	116-122	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	0-4
31933404-6	2020	The MCU inhibitor, Ru360, significantly reduced the rate of seizure-induced cell apoptosis and mitochondrial reactive oxygen species (ROS) production; whereas, the MCU agonist, spermine, exacerbated these processes.	Oxygen	118-124	mitochondrial calcium uniporter	Homo sapiens	4-7
32945393-7	2020	The present study, based on bioinformatics analysis and experimental studies in vivo and in vitro, demonstrated that Hpa enhanced the crosstalk between TNBC cells and PLT to increase the supply of oxygen and nutrients, while also conferring tolerance of TNBC cells to oxygen and nutrient shortage, both of which are important for overcoming the stress of hypoxia and nutritional deprivation in the tumor microenvironment, thereby promoting malignant progression, including growth, angiogenesis and metastasis in TNBC.	Oxygen	268-274	heparanase	Homo sapiens	117-120
33117401-6	2020	To confirm a potential cause-effect, we performed experiments with tumor cell lines showing increased expression upon in vitro exposure to 1% oxygen or dimethyloxalylglycine, an inhibitor of prolyl hydroxylases, indicating that Sdc-3 expression is promoted by hypoxia inducible factors (HIFs).	Oxygen	142-148	syndecan 3	Homo sapiens	228-233
32943729-0	2020	Androgen receptor modulates metastatic routes of VHL wild-type clear cell renal cell carcinoma in an oxygen-dependent manner.	Oxygen	101-107	androgen receptor	Homo sapiens	0-17
32943729-3	2020	Here we found that AR interacted with VHL to modulate the metastasis of VHL-wt ccRCC via an oxygen-dependent manner.	Oxygen	92-98	androgen receptor	Homo sapiens	19-21
32943729-6	2020	These distinct AR functions under different oxygen conditions may involve the VHL-impacted ubiquitination and nuclear localization of AR.	Oxygen	44-50	androgen receptor	Homo sapiens	15-17
32943729-6	2020	These distinct AR functions under different oxygen conditions may involve the VHL-impacted ubiquitination and nuclear localization of AR.	Oxygen	44-50	androgen receptor	Homo sapiens	134-136
32943729-7	2020	The differential regulation of VEGF-A vs VEGF-C by AR may then result in differential impacts on the ccRCC metastatic destinations of VHL-wt ccRCC cells under different oxygen conditions.	Oxygen	169-175	vascular endothelial growth factor A	Homo sapiens	31-37
32943729-7	2020	The differential regulation of VEGF-A vs VEGF-C by AR may then result in differential impacts on the ccRCC metastatic destinations of VHL-wt ccRCC cells under different oxygen conditions.	Oxygen	169-175	vascular endothelial growth factor C	Homo sapiens	41-47
32943729-7	2020	The differential regulation of VEGF-A vs VEGF-C by AR may then result in differential impacts on the ccRCC metastatic destinations of VHL-wt ccRCC cells under different oxygen conditions.	Oxygen	169-175	androgen receptor	Homo sapiens	51-53
32949969-0	2020	Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation.	Oxygen	83-89	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32949969-7	2020	Induction of HO-1 and GCLM by SFN (2.5 muM) was significantly attenuated in cells adapted to 5 kPa O2, despite nuclear accumulation of Nrf2.	Oxygen	99-101	heme oxygenase 1	Mus musculus	13-17
32673849-10	2020	Moreover, NLRP3 signaling pathway activated by Pb-caused oxidative stress was up-regulated accompanied by promotion in reactive oxygen species, nitric oxide, inducible nitric oxide synthase and malondialdehyde and reduction in antioxidants including glutathione peroxidase and glutathione s-transferase.	Oxygen	128-134	NLR family pyrin domain containing 3	Gallus gallus	10-15
33027675-6	2020	Scavenging paramagnetic byproducts of oxygen metabolism with SOD2 in hepatic mitochondria fully abolishes these insulin sensitizing effects, demonstrating that mitochondrial superoxide mediates induction of these therapeutic changes.	Oxygen	38-44	superoxide dismutase 2, mitochondrial	Mus musculus	61-65
32778291-5	2020	Up to 468 mL L-1 of hydrogen and 203 mg L-1 of poly-beta-hydroxybutyrate can be produced starting from an initial chemical oxygen demand of 1500 mg L-1.	Oxygen	123-129	L1 cell adhesion molecule	Homo sapiens	13-16
32778291-5	2020	Up to 468 mL L-1 of hydrogen and 203 mg L-1 of poly-beta-hydroxybutyrate can be produced starting from an initial chemical oxygen demand of 1500 mg L-1.	Oxygen	123-129	L1 cell adhesion molecule	Homo sapiens	40-43
32778291-5	2020	Up to 468 mL L-1 of hydrogen and 203 mg L-1 of poly-beta-hydroxybutyrate can be produced starting from an initial chemical oxygen demand of 1500 mg L-1.	Oxygen	123-129	L1 cell adhesion molecule	Homo sapiens	40-43
32945382-10	2020	The expression levels of hypoxia-inducible factor 1-alpha and NLRP3 increased after oxygen and glucose deprivation (OGD), and reduced after treatment with OGD and TMP (all P<0.05).	Oxygen	84-90	NLR family, pyrin domain containing 3	Rattus norvegicus	62-67
33020645-1	2020	Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (ccRCC).	Oxygen	55-61	vascular endothelial growth factor A	Homo sapiens	184-188
32015457-11	2020	Moreover, the inhibition of NFE2L2/NRF2, which was predicted in silico, could be playing a critical role in the reduction of reactive oxygen species (ROS).	Oxygen	134-140	NFE2 like bZIP transcription factor 2	Homo sapiens	28-34
32015457-11	2020	Moreover, the inhibition of NFE2L2/NRF2, which was predicted in silico, could be playing a critical role in the reduction of reactive oxygen species (ROS).	Oxygen	134-140	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
33049519-2	2020	Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes the dismutation of superoxide radicals (O2 -) in mitochondria.	Oxygen	128-132	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
33049519-2	2020	Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes the dismutation of superoxide radicals (O2 -) in mitochondria.	Oxygen	128-132	superoxide dismutase 2, mitochondrial	Mus musculus	32-37
33049519-8	2020	Oxidative phosphorylation (OXPHOS) measurement using a Seahorse XF analyzer in SOD2Delta neonatal cardiomyocytes and adult cardiac mitochondria displayed reduced O2 consumption, particularly during basal conditions and after the addition of FCCP (H+ ionophore/uncoupler), compared to that in SOD2fl hearts.	Oxygen	162-164	superoxide dismutase 2, mitochondrial	Mus musculus	79-88
33049519-8	2020	Oxidative phosphorylation (OXPHOS) measurement using a Seahorse XF analyzer in SOD2Delta neonatal cardiomyocytes and adult cardiac mitochondria displayed reduced O2 consumption, particularly during basal conditions and after the addition of FCCP (H+ ionophore/uncoupler), compared to that in SOD2fl hearts.	Oxygen	162-164	superoxide dismutase 2, mitochondrial	Mus musculus	79-83
33049519-9	2020	Measurement of extracellular acidification (ECAR) to examine glycolysis in these cells showed a pattern precisely opposite that of the oxygen consumption rate (OCR) among SOD2Delta mice compared to their SOD2fl littermates.	Oxygen	135-141	superoxide dismutase 2, mitochondrial	Mus musculus	171-180
33049519-9	2020	Measurement of extracellular acidification (ECAR) to examine glycolysis in these cells showed a pattern precisely opposite that of the oxygen consumption rate (OCR) among SOD2Delta mice compared to their SOD2fl littermates.	Oxygen	135-141	superoxide dismutase 2, mitochondrial	Mus musculus	171-175
33564369-1	2020	Objective: To study the serum levels of fibrinogen and d-dimer in patients with obstructive sleep apnea (OSA) and its correlation with apnea hypopnea index (AHI), oxygen desaturation index (ODI), minimal oxygen saturation and arousal index.	Oxygen	163-169	fibrinogen beta chain	Homo sapiens	40-50
33564369-1	2020	Objective: To study the serum levels of fibrinogen and d-dimer in patients with obstructive sleep apnea (OSA) and its correlation with apnea hypopnea index (AHI), oxygen desaturation index (ODI), minimal oxygen saturation and arousal index.	Oxygen	204-210	fibrinogen beta chain	Homo sapiens	40-50
33564369-5	2020	Serum fibrinogen co-related positively with AHI (r=0.6381, p=0.0011) and ODI (r=0.7434, p=0.0000), negatively with minimal oxygen saturation (r=-0.4461, p=0.0329).	Oxygen	123-129	fibrinogen beta chain	Homo sapiens	6-16
32957125-0	2020	Assessment of insulin sensitivity during hyperbaric oxygen treatment.	Oxygen	52-58	insulin	Homo sapiens	14-21
33062139-6	2020	Intriguingly, these above effects of BAK were largely attributed to the remarkable activation of SIRT1/Nrf2 signaling, which eventually strengthened cardiac antioxidative capacity by elevating the antioxidant production and reducing the reactive oxygen species generation.	Oxygen	246-252	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
33117401-10	2020	In vitro experiments demonstrated that hypoxia (1% oxygen) or treatment with IFN-gamma stimulate Sdc-3 expression on RAW-264.7 derived macrophages, linking Sdc-3 expression to a proinflammatory response.	Oxygen	51-57	syndecan 3	Homo sapiens	97-102
33117401-10	2020	In vitro experiments demonstrated that hypoxia (1% oxygen) or treatment with IFN-gamma stimulate Sdc-3 expression on RAW-264.7 derived macrophages, linking Sdc-3 expression to a proinflammatory response.	Oxygen	51-57	syndecan 3	Homo sapiens	156-161
32809803-4	2020	In this system, (1) GC polymers with pH-sensitive surface charge switchability from neutral to positive could improve the PS accumulation within the tumor region, (2) CAT could effectively reoxygenate the hypoxic tumor via catalyzing endogenous hydrogen peroxide to O2, and (3) MnO2 could consume the intracellular GSH while simultaneously producing Mn2+ as a contrast agent for T1-weighted MR imaging.	Oxygen	266-268	catalase	Homo sapiens	167-170
33117187-1	2020	Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity.	Oxygen	69-75	erythropoietin	Homo sapiens	0-14
33117187-1	2020	Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity.	Oxygen	69-75	erythropoietin	Homo sapiens	16-19
32978500-6	2020	We demonstrate retinal fibrosis within a murine model of oxygen-induced retinopathy resulting from the intravitreal injection of adipose Myh11-derived mesenchymal stem cells, with ensuing myofibroblast differentiation.	Oxygen	57-63	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	137-142
32973178-2	2020	To establish an alternative layer of control over these processes, we generated chimeric regulatory RNAs that interact reversibly and light-dependently with the light-oxygen-voltage photoreceptor PAL.	Oxygen	167-173	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	196-199
32856030-0	2020	Controlled phosphating: a novel strategy toward NiP3@CeO2 interface engineering for efficient oxygen evolution electrocatalysis.	Oxygen	94-100	BCL2 interacting protein 3	Homo sapiens	48-52
32856030-4	2020	The NiP3@CeO2/NF catalysts display a fairly small overpotential of 200 mV to achieve a current density of 25 mA cm-2 for the oxygen evolution reaction (OER) under alkaline conditions, 110 mV smaller than that of NiO@CeO2/NF.	Oxygen	125-131	BCL2 interacting protein 3	Homo sapiens	4-8
33117187-6	2020	An interaction effect was found between treatment condition and sex resulting in higher peak oxygen consumption (p = 0.048) and ventilation (p = 0.044) in EPO-treated males.	Oxygen	93-99	erythropoietin	Homo sapiens	155-158
32959547-11	2020	Sputum production, chest discomfort, a large number of symptoms, abnormal procalcitonin and C-reactive protein levels, and abnormal chest X-ray or chest computed tomography findings were more common in patients requiring supplemental oxygen than in those not requiring supplemental oxygen.	Oxygen	234-240	C-reactive protein	Homo sapiens	92-110
31954830-5	2020	Similarly, the levels of the NLRP1 inflammasome proteins, cleaved caspase-1, mature IL-1beta and IL-18 were elevated in SY-5Y cells exposed to oxygen-glucose deprivation (OGD).	Oxygen	143-157	NLR family pyrin domain containing 1	Homo sapiens	29-34
32961733-4	2020	From the four discriminant functions, it can be extracted that the presence of sp3 carbons, ramifications, and secondary amine groups in a molecule enhance antibacterial activity, whereas the presence of 5-member rings, sp2 carbons, and sp2 oxygens hinder it.	Oxygen	241-248	Sp3 transcription factor	Homo sapiens	79-82
32822167-4	2020	The Li6+xP1-xSixS5I solid electrolytes are employed in ASSLBs with Li(Ni0.8Mn0.1Co0.1)O2 (NCM-811) as cathode and Li metal as anode to evaluate the electrochemical performance.	Oxygen	86-88	XPA, DNA damage recognition and repair factor	Homo sapiens	8-11
32942546-8	2020	Results emphasize the importance of active oxygen species in inducing nucleotide lesions at a p53 mutational hotspot in HCV-HCC patients living in geographical areas without dietary exposure to aflatoxin B1.	Oxygen	43-49	tumor protein p53	Homo sapiens	94-97
32948821-6	2020	The ability of C3G to reduce plasma and hepatic triglycerides, glucose tolerance, and adiposity and to induce oxygen consumption and energy expenditure was abrogated in PPARalpha-deficient mice, suggesting that PPARalpha is the major target for C3G.	Oxygen	110-116	peroxisome proliferator activated receptor alpha	Mus musculus	169-178
32983414-2	2020	We now know that an elaborate oxygen-sensing mechanism regulates the production of EPO, which in turn promotes the maturation and survival of erythroid progenitors.	Oxygen	30-36	erythropoietin	Homo sapiens	83-86
32984087-9	2020	Consistent with bladder ischemia, incubation of cultured human bladder smooth muscle cells at low oxygen tension increased both ASK1 and caspase-3 expression, insinuating hypoxia as an essential factor in ASK1 and caspase-3 upregulation.	Oxygen	98-104	caspase 3	Homo sapiens	137-146
32702447-6	2020	Moreover, we demonstrated that mitochondrial abnormalities such as elevated reactive oxygen species, decreased membrane potential, and fragmentation and accumulation of mitochondrial mass, occurred in AngII-treated RTECs.	Oxygen	85-91	angiotensinogen	Homo sapiens	201-206
32927872-0	2020	A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting that Central Effects Can Be Avoided.	Oxygen	50-56	cannabinoid receptor 1	Homo sapiens	13-17
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	mitogen-activated protein kinase 8	Homo sapiens	138-161
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	mitogen-activated protein kinase 8	Homo sapiens	163-166
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	forkhead box O1	Homo sapiens	193-198
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	caspase 3	Homo sapiens	237-246
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	BCL2 apoptosis regulator	Homo sapiens	270-275
32562827-6	2020	The current results showed that the apoptosis in porcine GCs exposed to severe hypoxia (1% O2) was correlated with enhanced activation of c-Jun N-terminal kinase (JNK), nuclear accumulation of FOXO1, as well as elevated level of cleaved caspase-3 and decreased ratio of BCL-2/BAX.	Oxygen	91-93	BCL2 associated X, apoptosis regulator	Homo sapiens	276-279
32645581-4	2020	The effluent chemical oxygen demand (COD) content decreased from 150 to 78 mg L-1, and remained below a discharge limitation of 80 mg L-1, and the stable COD removal efficiencies (from 56.0% to 47.9%) indicated that catalyst deactivation, which primarily resulted from the deposition of inorganic salts on the surface of the catalyst that limited interaction between ozone and active sites and/or prevented electrons transfer, was primarily inhibited by backflushing.	Oxygen	22-28	L1 cell adhesion molecule	Homo sapiens	78-81
32941358-12	2021	Phenylephrine was found to be similar to vasopressin in the extent to which both decreased cerebral oxygen saturation values.	Oxygen	100-106	arginine vasopressin	Homo sapiens	41-52
32914752-6	2020	Mechanistically, mtCa2+ overload leads to increased mitochondrial reactive oxygen species, which activate HIF1alpha signaling supporting metastasis of NCLX-null tumor cells.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-115
32916960-7	2020	Thus, STIM1 deficiency leads to a strong reduction of ITPR3 transcript and ITPR3 protein levels, a consequent decrease of the mitochondria free Ca2+ concentration ([Ca2+]mit), reduction of mitochondrial oxygen consumption rate, and decrease in ATP synthesis rate.	Oxygen	203-209	stromal interaction molecule 1	Homo sapiens	6-11
32925409-2	2021	Hb Tak, resulting from a dinucleotide insertion (+AC) at codon 146 of beta-globin gene, has an increased oxygen affinity and usually presents with polycythemia.	Oxygen	105-111	cyclin dependent kinase 9	Homo sapiens	3-6
32954764-0	2020	Hyperbaric oxygen therapy cognitive function in a rat model of mild cognitive impairment via ERK signaling.	Oxygen	11-17	Eph receptor B1	Rattus norvegicus	93-96
32921708-11	2020	CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r = 0.37 and 0.42 respectively; p: <0.01).	Oxygen	91-97	C-reactive protein	Homo sapiens	0-3
32983164-5	2020	Considering that beta3-ARs are modulated by oxygen levels, we hypothesize that hypoxia, through the upregulation of beta3-AR, promotes the biological shift toward a tolerant immunophenotype and that this is the same trick that embryo and cancer use to create an aura of immune-tolerance in a competent immune environment.	Oxygen	44-50	adenosine A3 receptor	Mus musculus	17-25
32899412-3	2020	mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism.	Oxygen	73-79	mechanistic target of rapamycin kinase	Homo sapiens	0-4
32768982-4	2020	Sorafenib inhibits tumor angiogenesis, and catalase decomposes hydrogen peroxide (H2O2) to generate oxygen in the tumor.	Oxygen	100-106	catalase	Homo sapiens	43-51
32585606-5	2020	An increase in HIF-1alpha may participate in the pathogenesis of psoriasis in association with IL-6, vascular endothelial growth factor (VEGF), microRNA-150, microRNA-270, reactive oxygen species, bone morphogenetic protein 6 (BMP6), triggering receptor expressed on myeloid cells 1 (TREM-1) and phosphoinositide 3-kinases (PI3K)/Akt pathway.	Oxygen	181-187	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
32388262-6	2020	The mean dioxin-like PCB and polychlorinated naphthalene TEQs were ~8.9 and ~6.6 times higher in stack gases from a SCu equipped with an oxygen-enriched smelting furnace than in stack gases from a SCu with a converter furnace.	Oxygen	137-143	pyruvate carboxylase	Homo sapiens	21-24
33119829-3	2020	The mechanism of stabilization of the oxygen-sensitive HIF1alpha subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1alpha protein.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-64
33119829-3	2020	The mechanism of stabilization of the oxygen-sensitive HIF1alpha subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1alpha protein.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	260-269
32433978-5	2020	CRT was knocked down or overexpressed in T84 cells, which were analyzed by immunofluorescence, immunoblots, high-performance liquid chromatography (to measure creatine levels), qPCR, transepithelial electrical resistance, barrier function, actin localization, wound healing, mitochondrial oxygen consumption, and glycolysis extracellular acidification rate assays.	Oxygen	289-295	calcitonin receptor	Homo sapiens	0-3
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	Oxygen	304-310	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	83-105
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	Oxygen	304-310	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	107-110
32815446-10	2020	Impaired endothelial function with above-normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin-6.	Oxygen	85-91	dual oxidase 2	Homo sapiens	162-213
32640283-5	2020	In PVNCs, exposure to 10% oxygen induced myocyte proliferation concurrent with molecular markers of cell-cycle progression, such as Cyclin-D1, which were prevented by misoprostol treatment.	Oxygen	26-32	cyclin D1	Rattus norvegicus	132-141
32815446-10	2020	Impaired endothelial function with above-normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin-6.	Oxygen	85-91	interleukin 6	Homo sapiens	230-243
32017200-10	2020	Rather, inhibition of IL-10 production by CD73 was important for optimal reactive oxygen species (ROS) production by PMNs.	Oxygen	82-88	interleukin 10	Mus musculus	22-27
32982774-0	2020	Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase-3 Activation: A Study With the Kinase Inhibitor Staurosporine.	Oxygen	43-49	caspase 3	Homo sapiens	72-81
32891945-4	2020	Primary outcome was within-group blood-oxygen-level dependent activations that co-varied with EMG-Amp and EMG-Onset following correction for multiple comparisons for an overall cluster corrected p < 0.05.	Oxygen	39-45	adenine phosphoribosyltransferase	Homo sapiens	98-101
32527198-4	2020	Objective: Starting from our previous observations that the PP2A phosphatase regulates the HIF/PHD2-constituted oxygen machinery, we hypothesized that this axis could play an important role during blood vessel formation, tissue perfusion and oxygen restoration.	Oxygen	112-118	Protein phosphatase 2A at 29B	Drosophila melanogaster	60-64
32527198-4	2020	Objective: Starting from our previous observations that the PP2A phosphatase regulates the HIF/PHD2-constituted oxygen machinery, we hypothesized that this axis could play an important role during blood vessel formation, tissue perfusion and oxygen restoration.	Oxygen	112-118	HIF prolyl hydroxylase	Drosophila melanogaster	95-99
32527198-4	2020	Objective: Starting from our previous observations that the PP2A phosphatase regulates the HIF/PHD2-constituted oxygen machinery, we hypothesized that this axis could play an important role during blood vessel formation, tissue perfusion and oxygen restoration.	Oxygen	242-248	Protein phosphatase 2A at 29B	Drosophila melanogaster	60-64
32527198-4	2020	Objective: Starting from our previous observations that the PP2A phosphatase regulates the HIF/PHD2-constituted oxygen machinery, we hypothesized that this axis could play an important role during blood vessel formation, tissue perfusion and oxygen restoration.	Oxygen	242-248	HIF prolyl hydroxylase	Drosophila melanogaster	95-99
32909001-6	2020	Notably, members of the TNF superfamily and IL-6 family were up-regulated in patients on oxygen support with severe and moderate disease.	Oxygen	89-95	interleukin 6	Homo sapiens	44-48
32804466-7	2020	In a second test, rats received oxygen alone or antitumor necrosis factor (TNF)-alpha monoclonal antibody with oxygen or H2.	Oxygen	111-117	tumor necrosis factor	Rattus norvegicus	48-85
32984222-5	2020	High oxygen tension and decreased prostaglandin levels mediated by numerous factors including potassium channels, endothelin-1, isoprostanes lead to the contraction of the ductus.	Oxygen	5-11	endothelin 1	Homo sapiens	114-126
32631903-0	2020	Janus Kinase mutations in mice lacking PU.1 and Spi-B drive B cell leukemia through reactive oxygen species-induced DNA damage.	Oxygen	93-99	Spi-B transcription factor (Spi-1/PU.1 related)	Mus musculus	48-53
32641622-4	2020	NRDP1 and COQ8A were expressed at higher levels in yak and dzo compared to those in cattle, indicating higher endurance capacity of yak and dzo in a low-oxygen environment.	Oxygen	153-159	coenzyme Q8A	Bos taurus	10-15
32833955-0	2020	Qi-Xian Decoction Upregulated E-cadherin Expression in Human Lung Epithelial Cells and Ovalbumin-Challenged Mice by Inhibiting Reactive Oxygen Species-Mediated Extracellular-Signal-Regulated Kinase (ERK) Activation.	Oxygen	136-142	cadherin 1	Homo sapiens	30-40
32904464-6	2020	Methods: The expression level of circHIPK3 in CFs under hypoxia (1% O2) was analyzed by qRT-PCR.	Oxygen	68-70	homeodomain interacting protein kinase 3	Homo sapiens	33-42
32838805-8	2020	We further found that PANX1 channel inhibition during in vitro maturation resulted in temporarily delayed meiotic maturation and improved in vitro developmental outcomes while decreasing intercellular reactive oxygen species.	Oxygen	210-216	pannexin 1	Bos taurus	22-27
32833955-0	2020	Qi-Xian Decoction Upregulated E-cadherin Expression in Human Lung Epithelial Cells and Ovalbumin-Challenged Mice by Inhibiting Reactive Oxygen Species-Mediated Extracellular-Signal-Regulated Kinase (ERK) Activation.	Oxygen	136-142	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	87-96
32833955-0	2020	Qi-Xian Decoction Upregulated E-cadherin Expression in Human Lung Epithelial Cells and Ovalbumin-Challenged Mice by Inhibiting Reactive Oxygen Species-Mediated Extracellular-Signal-Regulated Kinase (ERK) Activation.	Oxygen	136-142	mitogen-activated protein kinase 1	Mus musculus	160-197
32833955-0	2020	Qi-Xian Decoction Upregulated E-cadherin Expression in Human Lung Epithelial Cells and Ovalbumin-Challenged Mice by Inhibiting Reactive Oxygen Species-Mediated Extracellular-Signal-Regulated Kinase (ERK) Activation.	Oxygen	136-142	mitogen-activated protein kinase 1	Mus musculus	199-202
32825707-6	2020	At pressures above 50 GPa, a spin crossover occurs when the fraction of iron Fe3+ ions in oxygen octahedra transits from the high-spin (HS, S = 5/2) to the low-spin (LS, S = 1/2) state.	Oxygen	90-96	glycophorin A (MNS blood group)	Homo sapiens	22-25
32401303-4	2020	Placental mTOR signaling regulates placental function, including oxygen and nutrient transport.	Oxygen	65-71	mechanistic target of rapamycin kinase	Homo sapiens	10-14
32697905-3	2020	Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the cobalt-based catalyst.	Oxygen	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32791328-2	2020	By genetic screening, we found that NADPH oxidases (Nox and Duox) associated with superoxide anion (O -2) are responsible for caspase-3 activation and delamination.	Oxygen	100-104	Dual oxidase	Drosophila melanogaster	60-64
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Oxygen	9-15	interleukin 1 beta	Homo sapiens	248-265
32706242-6	2020	Furthermore, the Cyt c worked normally under hypoxia conditions and could decompose H2O2 to O2 (with peroxidase-/catalase-like activity), resulting in synergistically improved therapeutic efficiency.	Oxygen	86-88	cytochrome c, somatic	Homo sapiens	17-22
32824903-13	2020	On the one part, an increased reliance of cardiomyocytes on the oxidation of free fatty acids, typical for insulin-resistant states, is associated with both a lower yield of ATP per oxygen molecule and lesser availability of ATP for contraction, which might decrease energetic efficiency of the first and second step of energy transfer from MVO2 to EW.	Oxygen	182-188	insulin	Homo sapiens	107-114
32702988-3	2020	This new approach exploits broad fluorescence from a charge-transfer (CT) state of BD1, which possesses: i) a significant Stokes shift of 181 nm in dichloromethane; and ii) a comparably-high CT-fluorescence quantum yield (Phiref=7.0+-0.2 %), which is independent from oxygen presence and quencher (perylene) concentration while also exhibiting a linear intensity dependence.	Oxygen	268-274	defensin beta 1	Homo sapiens	83-86
32891060-5	2020	Subsequently, excess H2O2 at the inflamed tissues can be decomposed into oxygen because of MnO2 as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release.	Oxygen	73-79	catalase	Homo sapiens	130-133
32442539-6	2020	Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a membrane-bound enzyme responsible for the development of reactive oxygen species in hyperglycaemia.	Oxygen	129-135	dual oxidase 2	Homo sapiens	0-51
32799475-2	2020	The cbb3 C family of cytochrome c oxidases, with the high-spin heme b3 and CuB in the active site, is a subfamily of the heme copper oxidases that can reduce both molecular oxygen, which is the main substrate, and nitric oxide.	Oxygen	173-179	cytochrome c, somatic	Homo sapiens	21-33
32824562-6	2020	A strong inverse correlation was also observed between cysteine-HSA and peak VO2/kg, an index of oxygen consumption associated with HF severity.	Oxygen	97-103	albumin	Homo sapiens	64-67
32601098-2	2020	In these studies, we intended to investigate the role of mitochondrial-derived reactive oxygen species in regulating NF-kappaB activation by studying transgenic mice that overexpress mitochondrial-targeted human catalase (mCAT).	Oxygen	88-94	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	117-126
32446711-3	2020	The natural ligand heme has two carboxylic acids which interact in the beta1 heme nitric oxide oxygen binding (HNOX) domain with the amino acids of the highly conserved Y-x-S-x-R motif.	Oxygen	95-101	BCL2 related protein A1	Homo sapiens	71-76
32728688-8	2020	Indeed, Gitr-/-Apoe-/- monocytes displayed decreased integrin levels, reduced recruitment to endothelium, and produced less reactive oxygen species.	Oxygen	133-139	tumor necrosis factor receptor superfamily, member 18	Mus musculus	8-12
32728688-8	2020	Indeed, Gitr-/-Apoe-/- monocytes displayed decreased integrin levels, reduced recruitment to endothelium, and produced less reactive oxygen species.	Oxygen	133-139	apolipoprotein E	Mus musculus	15-19
32922435-2	2020	Their most prominent roles in vertebrates are the transport and storage of O2 for oxidative energy metabolism, but recent research has suggested alternative, non-respiratory globin functions.	Oxygen	75-77	globin 1	Drosophila melanogaster	174-180
32903604-10	2020	MiR-34a down-regulation also decreased reactive oxygen species accumulation (0.36-fold decrease), and promoted superoxide dismutase activity and the expression of SIRT1 (1.24-fold increase), heme oxygenase-1 and nuclear factor erythroid 2 like 2 to inhibit oxidative stress in septic mice.	Oxygen	48-54	microRNA 34a	Mus musculus	0-7
32663396-0	2020	Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guide-lines for Targeting alpha-Helix Backbone Oxygen by Halogen Bonding.	Oxygen	163-169	phosphodiesterase 5A	Homo sapiens	19-40
32450093-3	2020	Here, a six-arginine-tailed anti-epidermal growth factor receptor (EGFR) affibody was employed to easily synthesize the highly reactive oxygen species (hROS)- and trypsin-responsive 11-mercaptoundecanoic acid-modified gold nanoclusters (MUA-Au NCs) for tumor-targeted drug delivery.	Oxygen	136-142	epidermal growth factor receptor	Homo sapiens	33-65
32806555-8	2020	The upregulation of p-ERK occurred due to mitochondrial translocation of p53, which resulted in increased production of reactive oxygen species, causing the activation of receptor tyrosine kinases (RTKs).	Oxygen	129-135	mitogen-activated protein kinase 1	Homo sapiens	22-25
32806555-8	2020	The upregulation of p-ERK occurred due to mitochondrial translocation of p53, which resulted in increased production of reactive oxygen species, causing the activation of receptor tyrosine kinases (RTKs).	Oxygen	129-135	tumor protein p53	Homo sapiens	73-76
32716448-9	2020	Furthermore, slow (>12 hours), but not rapid (<1 hour), fluctuations in O2 tension impact HIF-1alpha mediated proliferation and migration.	Oxygen	72-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
32806656-4	2020	The oxygen permeation fluxes across a Ce0.9Pr0.1O2-delta-Nd0.5Sr0.5Fe0.9Cu0.1O3-delta membrane reached up to 1.02 mL min-1 cm-2 and 0.63 mL min-1 cm-2 under an air/He and air/CO2 gradient at T = 1223 K, respectively.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	117-127
32806656-4	2020	The oxygen permeation fluxes across a Ce0.9Pr0.1O2-delta-Nd0.5Sr0.5Fe0.9Cu0.1O3-delta membrane reached up to 1.02 mL min-1 cm-2 and 0.63 mL min-1 cm-2 under an air/He and air/CO2 gradient at T = 1223 K, respectively.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	140-150
32450093-3	2020	Here, a six-arginine-tailed anti-epidermal growth factor receptor (EGFR) affibody was employed to easily synthesize the highly reactive oxygen species (hROS)- and trypsin-responsive 11-mercaptoundecanoic acid-modified gold nanoclusters (MUA-Au NCs) for tumor-targeted drug delivery.	Oxygen	136-142	epidermal growth factor receptor	Homo sapiens	67-71
32771016-4	2020	Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration.	Oxygen	119-121	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	36-39
32850409-2	2020	Human melanomas often show hyperactivity of nitric oxide synthase (NOS) and NADPH oxidase (NOX), which, respectively, generate nitric oxide (NO   ) and superoxide (O2  - ).	Oxygen	164-169	nitric oxide synthase 2	Homo sapiens	44-65
32831861-6	2020	We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway.	Oxygen	148-154	C-reactive protein	Rattus norvegicus	53-71
32848706-3	2020	Alzheimer"s disease may occur when RAGE binds to Abeta and releases reactive oxygen species, further exacerbating Abeta deposition and eventually leading to SPs and NFTs.	Oxygen	77-83	amyloid beta precursor protein	Homo sapiens	114-119
32502633-0	2020	Oxygen-producing catalase-based prodrug nanoparticles overcoming resistance in hypoxia-mediated chemo-photodynamic therapy.	Oxygen	0-6	catalase	Homo sapiens	17-25
32756530-2	2020	The most common ROS, such as superoxide radical (O2-.) and hydrogen peroxide (H2O2), are scavenged by superoxide dismutase, peroxiredoxins, and catalase.	Oxygen	49-53	catalase	Homo sapiens	144-152
32780864-2	2020	Our previous work showed that CNTF-induced STAT3 signaling is a potent inhibitor of pathologic preretinal neovascular tuft formation in the mouse model of oxygen-induced retinopathy.	Oxygen	155-161	signal transducer and activator of transcription 3	Mus musculus	43-48
32502633-5	2020	Oxygen production efficiently decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and P-glycoprotein (P-gp), which enhanced chemotherapy efficiency.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-89
32502633-5	2020	Oxygen production efficiently decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and P-glycoprotein (P-gp), which enhanced chemotherapy efficiency.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
32502633-5	2020	Oxygen production efficiently decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and P-glycoprotein (P-gp), which enhanced chemotherapy efficiency.	Oxygen	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	107-121
32339495-2	2020	The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).	Oxygen	25-31	erythropoietin	Homo sapiens	184-187
32502633-5	2020	Oxygen production efficiently decreased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and P-glycoprotein (P-gp), which enhanced chemotherapy efficiency.	Oxygen	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	123-127
32339495-2	2020	The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	189-193
32450254-0	2020	Oxygen-releasing Manganese clay Hybrid Complex triggers p53-mediated cancer cell death in hypoxia.	Oxygen	0-6	tumor protein p53	Homo sapiens	56-59
32339495-2	2020	The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).	Oxygen	147-153	erythropoietin	Homo sapiens	184-187
32686520-4	2020	The ATP release is dependent on caspase-3/7 activation induced by mitochondrial reactive oxygen species.	Oxygen	89-95	caspase 3	Homo sapiens	32-43
32450254-5	2020	In hypoxia, the oxygen from MHC releases cells from S-phase arrest thus causing p53-dependent apoptosis.	Oxygen	16-22	tumor protein p53	Homo sapiens	80-83
32450254-7	2020	The released oxygen from MHC triggers apoptosis via p53 activation through its enhanced homo-oligomerization, post-translational modifications and nuclear localization.	Oxygen	13-19	tumor protein p53	Homo sapiens	52-55
32464763-8	2020	It was suspected that O2 - and H2O2 played important roles in the formation of  OH and the cycle of Co(II)/Co(III) and Ni(II)/Ni(III).	Oxygen	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31933062-6	2020	Knockout of USP15 significantly reduced intracellular reactive oxygen species (ROS) levels and enhanced superoxide dismutase (SOD) activity in HT22 cells under the exposure to glutamate treatment.	Oxygen	63-69	ubiquitin specific peptidase 15	Mus musculus	12-17
32590225-1	2020	TNF Receptor Associated Protein 1 (TRAP1) is a mitochondrial paralog of Hsp90 related to the promotion of tumorigenesis in various cancers via maintaining mitochondrial integrity, reducing the production of reactive oxygen species, and reprogramming cellular metabolism.	Oxygen	216-222	heat shock protein 86, pseudogene 2	Mus musculus	72-77
31727766-0	2020	CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness-genes and can be targeted by the BCL2 inhibitor Venetoclax.	Oxygen	63-69	CD34 molecule	Homo sapiens	0-4
32674688-8	2022	The highest selectivity to N2 (99.3) exhibited by the RhMo6/ZrAl-10 catalyst is proposed to be related to the high Rh dispersion (0.755) and to the presence of Lewis acid sites (oxygen vacancies) of the tetragonal ZrO2 modification that favour NO3 - adsorption through electrostatic interactions.	Oxygen	178-184	NBL1, DAN family BMP antagonist	Homo sapiens	244-247
32527531-3	2020	Catalase is a metalloenzyme which is essential for the breakdown of toxic hydrogen peroxide into water and oxygen inside the cell.	Oxygen	107-113	catalase	Homo sapiens	0-8
32513813-4	2020	Moreover, we see that foxo mutant animals show misregulated glucose metabolism in low oxygen and subsequently exhibit reduced hypoxia survival.	Oxygen	86-92	forkhead box, sub-group O	Drosophila melanogaster	22-26
32513813-7	2020	Together, these data indicate that FOXO is a hypoxia inducible factor that mediates tolerance to low oxygen by inducing immune-like responses.	Oxygen	101-107	forkhead box, sub-group O	Drosophila melanogaster	35-39
31727766-0	2020	CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness-genes and can be targeted by the BCL2 inhibitor Venetoclax.	Oxygen	63-69	BCL2 apoptosis regulator	Homo sapiens	149-153
32412317-3	2020	Insufficiency of glucose and oxygen supply could increase the radioresistance of cervical cancer cells through regulating hypoxia-inducible factor 1 (HIF-1) in tumor microenvironment and glucose metabolism.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-148
31705800-9	2020	CONCLUSION: Hepatic overexpression of CXCL1 is sufficient to drive steatosis-to-NASH progression in HFD-fed mice through neutrophil-derived reactive oxygen species and activation of stress kinases, which can be reversed by IL-22 treatment via the induction of metallothionein.	Oxygen	149-155	chemokine (C-X-C motif) ligand 1	Mus musculus	38-43
32412317-3	2020	Insufficiency of glucose and oxygen supply could increase the radioresistance of cervical cancer cells through regulating hypoxia-inducible factor 1 (HIF-1) in tumor microenvironment and glucose metabolism.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-155
32433359-8	2020	Mel significantly reduced the levels of NF-kappaB after astrocyte oxygen and glucose deprivation/reoxygenation injury, and this effect was offset when MT2 was silenced.	Oxygen	66-72	nuclear factor kappa B subunit 1	Homo sapiens	40-49
32573678-14	2020	In vitro, TNF-alpha increased mitochondrial oxygen consumption and glycolysis, but inhibited the ATP generation, which was reversed by AniHBr.	Oxygen	44-50	tumor necrosis factor	Rattus norvegicus	10-19
32740581-8	2020	RESULTS: Hyperbaric oxygen therapy with 3 atm increased viability, proliferation, and CD34 expression and reduced the CD31/CD34/CD45 adipose-derived stem cell subset and endothelial progenitor cell population.	Oxygen	20-26	CD34 molecule	Homo sapiens	86-90
32740581-8	2020	RESULTS: Hyperbaric oxygen therapy with 3 atm increased viability, proliferation, and CD34 expression and reduced the CD31/CD34/CD45 adipose-derived stem cell subset and endothelial progenitor cell population.	Oxygen	20-26	CD34 molecule	Homo sapiens	123-127
33884352-0	2020	COMPARATIVE ANALYSIS OF qPCR MEASUREMENT OF HIV VIRAL LOAD AND ELISA DETECTION OF p24 ANTIGEN AFTER HYPERBARIC OXYGEN EXPOSURE.	Oxygen	111-117	transmembrane p24 trafficking protein 2	Homo sapiens	82-85
33884352-9	2020	Hyperbaric oxygen therapy can reduce virus numbers, as observed from the p24 antigen and HIV-1 mRNA levels.	Oxygen	11-17	transmembrane p24 trafficking protein 2	Homo sapiens	73-76
32428596-1	2020	AIMS: Since the role of the major mitochondrial NAD+-dependent deacetylase, sirtuin 3 (Sirt3), is differential in cancer, opposite to the well-known tumor-suppressing effect of hyperoxia, this study aimed to investigate the role of Sirt3 in triple-negative breast cancer (TNBC) cell line MDA-MB-231 upon hyperoxic (95% O2) conditions.	Oxygen	319-321	sirtuin 3	Homo sapiens	87-92
32626962-0	2020	Troxerutin attenuates oxygen-glucose deprivation and reoxygenation-induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF-1alpha signaling pathway in H9C2 cardiomyocytes.	Oxygen	22-28	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
32623664-5	2020	Moreover, beta-asarone pretreatment also activated nuclear factor 2 erythroid-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1), which was involved in quenching reactive oxygen to inhibit oxidative stress.	Oxygen	133-139	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
32691071-0	2020	Retraction: LncRNA MALAT1up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targeting miR-145.	Oxygen	129-135	vascular endothelial growth factor A	Homo sapiens	38-44
32802113-2	2020	F. H. Chen played a neuroprotective role by affecting the EGFR/PI3K/AKT pathway in oxygen-glucose deprived (OGD) SH-SY5Y cells.	Oxygen	83-89	epidermal growth factor receptor	Homo sapiens	58-62
32802113-2	2020	F. H. Chen played a neuroprotective role by affecting the EGFR/PI3K/AKT pathway in oxygen-glucose deprived (OGD) SH-SY5Y cells.	Oxygen	83-89	AKT serine/threonine kinase 1	Homo sapiens	68-71
33329838-2	2020	This study aimed to determine whether the various finger probes of the MP570T pulse oximeter (MEK-ICS Co., Ltd., Korea) would provide clinically reliable peripheral oxygen saturation (SpO2) readings over a range of 70-100% arterial oxygen saturation (SaO2) during non-motion conditions.	Oxygen	165-171	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
32728964-3	2020	Post-deposition thermal annealing is conducted at 300  C in the ambience of oxygen (O2) for 1 h. With strong oxidizing agent O3 and post-deposition TA in growing ZnO, intrinsic strain and stress are reduced to 0.49% and 2.22 GPa, respectively, with extremely low background electron concentration (9.4 x 1015 cm-3).	Oxygen	84-86	glycophorin A (MNS blood group)	Homo sapiens	225-228
32571767-4	2020	To explore this issue in a spatial and temporally-controlled manner we developed a genetically encoded sensor by fusing the O2-labile Hypoxia-Inducible Factor 1alpha to eGFP and a tamoxifen-regulated Cre recombinase.	Oxygen	124-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-165
32633480-0	2020	2D- MOFs with Ni(II), Cu(II) and Co(II) as Efficient Oxygen Evolution Electrocatalysts: Rationalization of Catalytic Performance vs Structure of the MOFs and Potential of the Redox Couples.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32848840-0	2020	Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.	Oxygen	141-147	CF transmembrane conductance regulator	Homo sapiens	0-51
32848840-0	2020	Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.	Oxygen	141-147	CF transmembrane conductance regulator	Homo sapiens	53-57
32378311-2	2020	The dimeric alumoxane [K{Al(NON Dipp )(O)}] 2 reacts with carbon monoxide to afford the oxygen analogue of 3 , [K{Al(NON Dipp )(O 2 C)}] 2 [ 4 ] 2 containing the hitherto unknown ethenetetraolate ligand, [C 2 O 4 ] 4- .	Oxygen	88-94	nudix hydrolase 3	Homo sapiens	121-125
32831635-8	2020	In this context, we found that HIF-1alpha protein levels were elevated by combined mechanical strain and hypoxic conditions, whereas gas-permeable plates providing sufficient oxygen supply prevented HIF-1alpha stabilization at the protein level after pressure application on macrophages.	Oxygen	175-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	199-209
32689999-9	2020	The more the number of most predictive minor criteria strongly associated to mortality, i.e. arterial oxygen pressure/fraction inspired oxygen <= 250 mmHg, confusion, and uremia, present, the higher the CIRP level.	Oxygen	102-108	cold inducible RNA binding protein	Homo sapiens	203-207
32689999-9	2020	The more the number of most predictive minor criteria strongly associated to mortality, i.e. arterial oxygen pressure/fraction inspired oxygen <= 250 mmHg, confusion, and uremia, present, the higher the CIRP level.	Oxygen	136-142	cold inducible RNA binding protein	Homo sapiens	203-207
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	BRCA1 associated protein 1	Homo sapiens	151-155
32707731-6	2020	Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion.	Oxygen	163-169	NLR family pyrin domain containing 3	Homo sapiens	200-205
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	BRCA1 associated protein 1	Homo sapiens	193-197
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	forkhead box K1	Homo sapiens	204-209
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	signal transducer and activator of transcription 3	Homo sapiens	302-307
32502935-7	2020	Changes in IGFBP-1 phosphorylation regulated by mTOR/AAR signaling and CK2 may represent a novel mechanism linking oxygen and nutrient availability to IGF-1 signaling in the decidua.	Oxygen	115-121	mechanistic target of rapamycin kinase	Homo sapiens	48-52
32558533-0	2020	Metal-Organic Frameworks-Derived NiS/Fe3O4 Heterostructure Decorated Carbon Nanotubes as Highly Efficient and Durable Electrocatalyst for Oxygen Evolution Reaction.	Oxygen	138-144	solute carrier family 5 member 5	Homo sapiens	33-36
32200243-3	2020	Electron spin resonance spectroscopy (ESR) and free radical quenching experiments indicate that various active species (SO4-/OH/O2-/1O2) are generated in the beta-CD-MnFe2O4/PMS system and that pollutants trapped in the cyclodextrin cavity are quickly degraded.	Oxygen	128-130	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	158-165
32832640-3	2020	The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen.	Oxygen	157-163	catalase	Homo sapiens	45-53
32502935-7	2020	Changes in IGFBP-1 phosphorylation regulated by mTOR/AAR signaling and CK2 may represent a novel mechanism linking oxygen and nutrient availability to IGF-1 signaling in the decidua.	Oxygen	115-121	insulin like growth factor 1	Homo sapiens	151-156
32320873-7	2020	Denitrification is an important NO3- attenuation mechanism which reduces NO3- to NH4, as demonstrated by the PCA analysis, which showed positive correlation of NO3- concentrations with dissolved oxygen and negative correlations with NH4+, Fe2+and Mn2+; the latter two species may act as the electron donors necessary for reduction of NO3-.	Oxygen	195-201	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
32320873-7	2020	Denitrification is an important NO3- attenuation mechanism which reduces NO3- to NH4, as demonstrated by the PCA analysis, which showed positive correlation of NO3- concentrations with dissolved oxygen and negative correlations with NH4+, Fe2+and Mn2+; the latter two species may act as the electron donors necessary for reduction of NO3-.	Oxygen	195-201	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
32320873-7	2020	Denitrification is an important NO3- attenuation mechanism which reduces NO3- to NH4, as demonstrated by the PCA analysis, which showed positive correlation of NO3- concentrations with dissolved oxygen and negative correlations with NH4+, Fe2+and Mn2+; the latter two species may act as the electron donors necessary for reduction of NO3-.	Oxygen	195-201	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
33000107-8	2020	Inflammatory markers such as C-reactive protein, D-dimer, ferritin, fibrin degradation product and interleukin-6 were significantly elevated (P <0.05) in patients who required oxygen therapy than those who did not require it, suggesting the potential role such markers could play in predicting prognosis in patients.	Oxygen	176-182	interleukin 6	Homo sapiens	99-112
32320873-7	2020	Denitrification is an important NO3- attenuation mechanism which reduces NO3- to NH4, as demonstrated by the PCA analysis, which showed positive correlation of NO3- concentrations with dissolved oxygen and negative correlations with NH4+, Fe2+and Mn2+; the latter two species may act as the electron donors necessary for reduction of NO3-.	Oxygen	195-201	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
32652517-8	2020	Nrf2 deficiency diminished the ability of PHC to ameliorate rI/R-induced histopathological alterations and reactive oxygen species release in the lungs; however, PHC inhibited NLRP3 signaling Nrf2-dependently, while it inhibited NF-kappaB signaling Nrf2-independently.	Oxygen	116-122	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
32312861-7	2020	Lower peak oxygen consumption (13.5+-3.8 versus 16.6+-4.7 mL min-1 kg-1, p<0.001) was observed in the former group.	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	61-71
32432600-7	2020	The compound H2L is non-fluorescent; however, in the presence of CdII and PbII, the compound H2L is highly fluorescent with well-separated excitation and emission wavelengths, indicating that the metal ion is coordinated through phenolic oxygen and imine nitrogen of the Schiff base blocking the PET (Photoinduced Electron Transfer) process and stimulating the CHEF (Chelation Enhanced Fluorescence) process, to increase the fluorescence intensity of H2L.	Oxygen	238-244	submaxillary gland androgen regulated protein 3B	Homo sapiens	74-78
32073833-2	2020	The reaction of the copper(I) complex of N,N,N",N"-tetramethypropylenediamine with a series of para-substituted nitrosobenzene derivatives leads to adducts in which the nitrosoarene (ArNO) is reduced by zero, one, or two electrons, akin to the isovalent species dioxygen, superoxide, and peroxide, respectively.	Oxygen	262-270	cytohesin 2	Homo sapiens	183-187
32378445-1	2020	Within the microenvironment of solid tumors, stress associated with deficit of nutrients and oxygen as well as tumor-derived factors triggers the phosphorylation-dependent degradation of the IFNAR1 chain of type I interferon (IFN1) receptor and ensuing suppression of the IFN1 pathway.	Oxygen	93-99	IFN1@	Homo sapiens	226-230
32627781-3	2020	In order to solve these shortcomings, we developed a single therapeutic agent based on a bovine serum albumin nanocarrier that can co-deliver the anti-angiogenic drug Sorafenib ("S") and the photosensitizer Ce6 ("C") along with a molecular oxygen supply based on MnO2 ("M") as a convenient one-pot formulated nanoscale agent (SCM@BSA).	Oxygen	240-246	albumin	Homo sapiens	96-109
32430170-6	2020	Exposure BMSCs from NCHD patients with D-galactose under hypoxia (4% O2) decreased the expression of Notch1.	Oxygen	69-71	notch receptor 1	Homo sapiens	101-107
32502376-7	2020	Ex vivo loss-of-function of Tead1 in primary cardiomyocytes also showed diminished aerobic respiration and maximal mitochondrial oxygen consumption capacity, demonstrating that TEAD1 regulation of OXPHOS, in cardiomyocytes, is cell-autonomous.	Oxygen	129-135	TEA domain transcription factor 1	Homo sapiens	28-33
32403045-2	2020	Sevoflurane combined with oxygen is widely applied in the clinic, and our previous study indicated that this regimen significantly reduced sepsis-induced inflammatory responses and that inhibition of NF-kappaB pathway activation may contribute to this protection effect.	Oxygen	26-32	nuclear factor kappa B subunit 1	Homo sapiens	200-209
31956955-6	2020	The function of SNHG3 on the growth and metabolism of tumor cells was used by CCK8 and mitochondrial oxygen consumption assays.	Oxygen	101-107	small nucleolar RNA host gene 3	Homo sapiens	16-21
32608429-9	2020	The reaction of with NO3 should mainly produce , CO2, O2 and NO2, which might play an important role in atmospheric chemistry of peroxy radicals at night, but has less contribution to the night-time conversion of ( and RO ) to ( and HO ) in the local atmosphere.	Oxygen	50-52	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
32413669-3	2020	DA treatment also promoted 3T3-L1 differentiation via PPAR-gamma activation, and mitochondrial oxygen consumption in HL7702 cells via PPAR-alpha activation.	Oxygen	95-101	peroxisome proliferator activated receptor alpha	Mus musculus	134-144
32458487-10	2020	In addition, decreasing lowest oxygen saturation (beta = -.159, P = .004) was also independently correlated with increasing hs-CRP concentrations in multivariate linear analysis after adjusting for confounders.	Oxygen	31-37	C-reactive protein	Homo sapiens	127-130
32706077-0	2020	Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear.	Oxygen	93-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
31656272-6	2020	In vitro study showed that oxygen-glucose deprivation (OGD) treatment significantly up-regulated expressions of MEG3, Bax, and cleaved caspase-3, and further promoted apoptosis of hBMECs, while si-MEG3 blocked these effects.	Oxygen	27-33	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
31953914-0	2020	TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.	Oxygen	161-167	TNF superfamily member 15	Homo sapiens	0-4
32475319-5	2020	The mito-ECFP/Ang II-induced oxygen consumption rate and extracellular acidification rate responses were blocked by AT1 blocker losartan (P<0.01) and a mitochondria-targeting superoxide scavenger mito-TEMPO (P<0.01).	Oxygen	29-35	angiotensin II receptor, type 1a	Mus musculus	116-119
31791154-0	2020	Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signaling.	Oxygen	58-64	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
31960438-8	2020	Additionally, pre-miR-214 overexpression increased the malondialdehyde and reactive oxygen species levels, upregulated Fe2+ concentration, and decreased glutathione levels in cancer cells exposed to erastin.	Oxygen	84-90	microRNA 214	Homo sapiens	18-25
32274893-3	2020	Insulin fine-tunes muscle microvascular perfusion to regulate its own action in muscle and oxygen and nutrient supplies to muscle.	Oxygen	91-97	insulin	Homo sapiens	0-7
32274893-10	2020	Thus, treatment of insulin resistant patients with GLP-1 receptor agonists may improve skeletal and cardiac muscle microvascular perfusion and increase muscle capillarization, leading to improved delivery of oxygen, nutrients, and hormones such as insulin to the myocytes.	Oxygen	208-214	insulin	Homo sapiens	19-26
32274893-10	2020	Thus, treatment of insulin resistant patients with GLP-1 receptor agonists may improve skeletal and cardiac muscle microvascular perfusion and increase muscle capillarization, leading to improved delivery of oxygen, nutrients, and hormones such as insulin to the myocytes.	Oxygen	208-214	insulin	Homo sapiens	248-255
32510356-6	2020	The lowest concentration of dissolved oxygen (3.6 mg L-1) was observed within the river plume.	Oxygen	38-44	L1 cell adhesion molecule	Homo sapiens	53-56
32617047-7	2020	The expression levels of catalase and SOD2 increased significantly after treatment with ginsenoside Mc1, resulting in a decrease in the production of H2O2-mediated reactive oxygen species.	Oxygen	173-179	catalase	Rattus norvegicus	25-33
32468046-0	2020	Excessive production of mitochondrion-derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3/SOD2 pathway.	Oxygen	55-61	sirtuin 3	Homo sapiens	149-154
32319636-3	2020	The low oxygen conditions in obese adipose tissues induce HIF-1alpha in adipocytes.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
32695777-11	2020	Additionally, we found that, as with cells from human premutation (PM) carriers, these cell lines have elevated mitochondrial copy numbers and Fmr1 hyperexpression, that we show here is O2-sensitive.	Oxygen	186-188	fragile X messenger ribonucleoprotein 1	Homo sapiens	143-147
32566011-3	2020	Hypoxia inducible factor-1alpha (HIF-1alpha) is the master transcriptional regulator of the cellular response to altered oxygen concentration.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
32566011-3	2020	Hypoxia inducible factor-1alpha (HIF-1alpha) is the master transcriptional regulator of the cellular response to altered oxygen concentration.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
32189529-5	2020	In BMSCs, exposure to low oxygen resulted in upregulation of TGF-beta1, whereas other target genes were unaffected.	Oxygen	26-32	transforming growth factor beta 1	Homo sapiens	61-70
32339783-9	2020	Our data revealed that MIF knockout accentuated side-stream smoke-induced cardiac anomalies in fractional shortening, cardiomyocyte function, intracellular Ca2+ homeostasis, myocardial ultrastructure and mitochondrial content along with overt apoptosis and O2- generation.	Oxygen	257-259	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	23-26
32587480-2	2020	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
32579210-0	2020	Expression of Concern: LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targetting miR-145.	Oxygen	141-147	vascular endothelial growth factor A	Homo sapiens	50-56
32587480-2	2020	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
32122941-4	2020	Recent work by our group suggests that during gut homeostasis, epithelial hypoxia derived from peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent beta-oxidation of microbiota-derived short-chain fatty acids limits oxygen availability in the colon, thereby maintaining a balanced microbial community.	Oxygen	235-241	peroxisome proliferator activated receptor gamma	Homo sapiens	95-143
32501468-2	2020	The sodium salt Na[1] reacts with oxophilic element halides such as OPCl3, PhSiCl3, PhBCl2 and CpTiCl3 at room temperature to form exclusively the oxygen bound tris-substituted compounds E(1)3 (with E = OP, PhSi, PhB- or CpTi).	Oxygen	147-153	carnitine palmitoyltransferase 1B	Homo sapiens	95-99
32164457-6	2020	Hypoxia inducible factors act to promote oxygen delivery (by stimulating erythropoietin and erythrocytosis) and decrease oxygen consumption.	Oxygen	41-47	erythropoietin	Homo sapiens	73-87
32656210-6	2020	Two candidate small molecules can prevent OIR by stabilizing HIF-1 to prevent oxygen induced growth attenuation and vascular obliteration.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
32122941-4	2020	Recent work by our group suggests that during gut homeostasis, epithelial hypoxia derived from peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent beta-oxidation of microbiota-derived short-chain fatty acids limits oxygen availability in the colon, thereby maintaining a balanced microbial community.	Oxygen	235-241	peroxisome proliferator activated receptor gamma	Homo sapiens	145-155
32655788-7	2020	In vitro IHR stimuli in human monocytic THP-1 cells resulted in gene promoter hypomethylation-mediated FPR1 over-expression, increased production of reactive oxygen species, and increased cell apoptosis, which could be reversed with re-methylation agent, folic acid, treatment.	Oxygen	158-164	GLI family zinc finger 2	Homo sapiens	40-45
32407092-2	2020	Here, we investigate a prototypical electronic energy transfer process, I(2P3/2)+O2(a1Deltag) I(2P1/2)+ O2(X3Sigmag-), which is of great importance for the chemical oxygen-iodine laser.	Oxygen	165-171	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	96-101
32558023-3	2020	Inducing metabolic reprogramming in donor cells could improve SCNT efficiency by priming cells to become more embryonic in nature before SCNT hypoxia inducible factor 1-alpha (HIF1-alpha), a transcription factor that allows for cell survival in low oxygen, promotes a metabolic switch from OXPHOS to glycolysis.	Oxygen	249-255	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-174
32558023-3	2020	Inducing metabolic reprogramming in donor cells could improve SCNT efficiency by priming cells to become more embryonic in nature before SCNT hypoxia inducible factor 1-alpha (HIF1-alpha), a transcription factor that allows for cell survival in low oxygen, promotes a metabolic switch from OXPHOS to glycolysis.	Oxygen	249-255	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-186
32546738-9	2020	Mutational analyses of key cysteine residues in TRPA1 (Cys421, Cys621, Cys641, and Cys665) and in TRPV1 (Cys258, Cys363, and Cys742) have suggested that multiple reactive oxygen and nitrogen species are intricately involved in activation of the channels via a broad range of modifications involving these cysteine residues.	Oxygen	171-177	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
32438803-1	2020	Oxygen vacancies (OVs) enhanced electrochemiluminescence (ECL) biosensing strategy using luminol thermally encapsulated in apoferritin (Lum@apoFt) as an efficient transducer was investigated for ultrasensitive biomarker detection.	Oxygen	0-6	lumican	Homo sapiens	136-139
32617075-8	2020	Passaged THP-1 cells, inheriting initial LPS challenge, presented with dysregulation of cytokine expression and oxygen consumption for up to 7 days after the initial LPS treatment.	Oxygen	112-118	GLI family zinc finger 2	Homo sapiens	9-14
32632417-11	2020	Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55 6% vs. 0 0%; P-value = 0 003) and serum C-reactive protein (CRP) levels >10 mg/dL (33 0% vs. 0 0%; P-value = 0 05) at admission than those with no oxygen requirements.	Oxygen	49-55	C-reactive protein	Homo sapiens	190-208
32632417-11	2020	Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55 6% vs. 0 0%; P-value = 0 003) and serum C-reactive protein (CRP) levels >10 mg/dL (33 0% vs. 0 0%; P-value = 0 05) at admission than those with no oxygen requirements.	Oxygen	49-55	C-reactive protein	Homo sapiens	210-213
32545801-6	2020	The results show that 1,25(OH)2D3 modulated Abeta-induced reactive oxygen species, apoptosis, and tau protein hyperphosphorylation in SH-SY5Y cells.	Oxygen	67-73	amyloid beta precursor protein	Homo sapiens	44-49
32532298-10	2020	In vitro, IFNgamma stimulation enhanced iP expression, reduced reactive oxygen species burden, and decreased oxidatively damaged and poly-ubiquitinated protein accumulation preferentially in human spinal cord astrocytes, which was abrogated with the use of the iP inhibitor, ONX 0914.	Oxygen	72-78	interferon gamma	Homo sapiens	10-18
32109798-1	2020	In this work, the influence of oxygen-containing surface groups of activated carbon electrodes on the charge efficiency of electro-assisted adsorption of As(V) was investigated.	Oxygen	31-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	154-159
32422149-6	2020	Moreover, we prove that such strategies are generalizable to other optical homo-dimerizers by demonstrating the optical TrkB activation based on the light-oxygen-voltage domain of aureochrome 1 from Vaucheria frigida.	Oxygen	155-161	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	120-124
32595496-7	2020	Concurrent neutralization of TNF-alpha, IL-1beta, and IL-6 with their antibodies provided better reduction in oxygen and glucose deprivation-induced increases in scar markers than obtained with separate use of each antibody.	Oxygen	110-116	tumor necrosis factor	Homo sapiens	29-38
32545500-8	2020	The adsorption and decomposition of CL-20 or FOX-7 on MgH2 could be attributed to the strong charge transfer between Mg atoms in the first layer of MgH2 (110) surface and oxygen as well as nitrogen atoms in the nitro-group of CL-20 or FOX-7 molecules.	Oxygen	171-177	epithelial membrane protein 1	Homo sapiens	36-41
32595496-7	2020	Concurrent neutralization of TNF-alpha, IL-1beta, and IL-6 with their antibodies provided better reduction in oxygen and glucose deprivation-induced increases in scar markers than obtained with separate use of each antibody.	Oxygen	110-116	interleukin 6	Homo sapiens	54-58
32596323-11	2020	Gene Ontology (GO) analysis indicated that these DEGs were significantly related to the positive regulation of epidermal growth factor-activated receptor activity, the positive regulation of the ERBB (erb-b2 receptor tyrosine kinase) signaling pathway, the differentiation of trophoblast giant cells, oxygen transport, immune-related pathways, and inflammation-related pathways.	Oxygen	301-307	epidermal growth factor receptor	Homo sapiens	195-199
32370869-6	2020	More importantly, using this probe, low dose reactive oxygen species induced GSH increasement through nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signal pathway in BEL-7402 cells was observed.	Oxygen	54-60	NFE2 like bZIP transcription factor 2	Homo sapiens	102-145
32370869-6	2020	More importantly, using this probe, low dose reactive oxygen species induced GSH increasement through nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signal pathway in BEL-7402 cells was observed.	Oxygen	54-60	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
32526922-5	2020	Furthermore, results of immunohistochemistry showed that the nuclear translocation of NF-kappaB/p65 and tyrosine nitration of cytoplasmic protein were stimulated by zoledronate, while MPMBP inhibited these phenomena, by acting as a superoxide anion (O2-) scavenger.	Oxygen	250-253	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-96
32596323-11	2020	Gene Ontology (GO) analysis indicated that these DEGs were significantly related to the positive regulation of epidermal growth factor-activated receptor activity, the positive regulation of the ERBB (erb-b2 receptor tyrosine kinase) signaling pathway, the differentiation of trophoblast giant cells, oxygen transport, immune-related pathways, and inflammation-related pathways.	Oxygen	301-307	erb-b2 receptor tyrosine kinase 2	Homo sapiens	201-207
32378412-8	2020	Besides, it is easier to generate H2O (WM) and a surface oxygen vacancy from the intermediate H2M/H4M than from H3M/H5M, which is related to the acid-base interaction between the HCe/M* and HO* in H2M/H4M.	Oxygen	57-63	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	179-182
32503642-1	2020	BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
32503642-1	2020	BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
32432250-0	2020	Microstructural dependent oxygen reduction reaction in a Ruddlesden-Popper perovskite (SmSr)NiO4-delta.	Oxygen	26-32	sterile alpha motif domain containing 8	Homo sapiens	87-91
32492108-3	2020	Methods: Expression levels of NF-kappaB signaling were detected by immunofluorescence staining and western blotting in retinas of oxygen-induced retinopathy (OIR) mice.	Oxygen	130-136	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
32396730-8	2020	Using bond-valence rules we propose a stoichiometry of Pb(II) binding on the hematite (11 02) surface which indicates proton release through the deprotonation of all oxygen groups bonding to Pb.	Oxygen	166-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-61
32766475-10	2020	Meanwhile, cellular oxidative stress increased as a result of ALR knockdown, indicating that ALR might also have a role in suppressing reactive oxygen species production.	Oxygen	144-150	growth factor, augmenter of liver regeneration	Mus musculus	62-65
32766475-10	2020	Meanwhile, cellular oxidative stress increased as a result of ALR knockdown, indicating that ALR might also have a role in suppressing reactive oxygen species production.	Oxygen	144-150	growth factor, augmenter of liver regeneration	Mus musculus	93-96
32193614-14	2020	CONCLUSION: The use of hyperbaric oxygen therapy increased the viability of cutaneous flaps in tobacco-exposed rats and decreased iNOS mRNA levels; however, it did not change VEGF-a levels.	Oxygen	34-40	nitric oxide synthase 2	Rattus norvegicus	130-134
32159374-0	2020	Dioxygen Binding and Sensing Proteins (O<sub>2</sub>BIP) : Editorial.	Oxygen	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	52-55
32048876-7	2020	Furthermore, scavengers of O2- or mitoROS prevented enhanced PKCbeta-dependent vasoconstrictor reactivity to endothelin-1 in pulmonary arteries from IH rats.	Oxygen	27-29	endothelin 1	Rattus norvegicus	109-121
32390510-4	2020	We measured total and isoform-specific PKC activity, basal and Ang II-stimulated oxygen consumption (QO2), a surrogate of Na reabsorption, and Cai in proximal tubules from rats drinking 20% fructose (FRUCT) and tap-water (Control).	Oxygen	81-87	angiotensinogen	Rattus norvegicus	63-69
31541481-1	2020	Cancer cell survival depends on the balance between reactive oxygen species production and scavenging, which is mainly regulated by NRF2 during tumorigenesis.	Oxygen	61-67	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
32272114-0	2020	Inhibition of retinal neovascularization by a PEDF-derived nonapeptide in newborn mice subjected to oxygen-induced ischemic retinopathy.	Oxygen	100-106	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	46-50
32129540-8	2020	Reactive oxygen species were generated in response to the hypoxia-mediated activation of caspase-1.	Oxygen	9-15	caspase 1	Homo sapiens	89-98
31990992-0	2020	Inhibition of microRNA-199a-5p ameliorates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO-1 signaling.	Oxygen	43-49	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
32147492-4	2020	This study aims to look at the effect of different concentrations of THC and CBD separately and in combination on the release of oxygen from erythrocytes by measuring the p50 of the oxygen haemoglobin dissociation curve.	Oxygen	129-135	nuclear factor kappa B subunit 1	Homo sapiens	171-174
31578733-4	2020	Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs.	Oxygen	245-251	ubiquitin specific peptidase 15	Homo sapiens	47-52
31897918-11	2020	Consequently, decreased reactive oxygen species levels and suppressed proinflammatory cytokine production were confirmed in casticin-treated IL-1beta-stimulated ADTC5 cells.	Oxygen	33-39	interleukin 1 beta	Mus musculus	141-149
31578733-4	2020	Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs.	Oxygen	245-251	kelch like ECH associated protein 1	Homo sapiens	92-127
31578733-4	2020	Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs.	Oxygen	245-251	kelch like ECH associated protein 1	Homo sapiens	129-134
31578733-4	2020	Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs.	Oxygen	245-251	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
32344470-5	2020	More importantly, in vitro experiments demonstrated that down-regulation of TNF-alpha in oxygen-glucose deprivation/reoxygenation (OGD/R) cells increased cell viability and decreased apoptosis and the p53 expression.	Oxygen	89-95	tumor necrosis factor	Rattus norvegicus	76-85
32088838-1	2020	Hypoxia refers to the decrease in oxygen tension in the tissues, and the central effector of the hypoxic response is the transcription factor Hypoxia-Inducible Factor alpha (HIF1-alpha).	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	174-184
31606810-7	2020	CONCLUSION: MOLLI T1-mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an [Formula: see text] in the range 4.18-4.8 x 10-3 s-1 mg-1 L and a corresponding LOD for dissolved oxygen of approximately 10 mg L-1.	Oxygen	75-81	L1 cell adhesion molecule	Homo sapiens	233-236
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	Oxygen	22-28	angiotensinogen	Rattus norvegicus	122-136
32281469-8	2020	In the flap model, Mif-/- knockout mice showed mitigated flap perfusion with lower hemoglobin content and oxygen saturation as measured by O2C measurements when compared to WT mice.	Oxygen	106-112	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	19-22
32374612-3	2020	The oxygen depletion inside the tumor provokes HIF-1 dependent gene and proteins expression which helps the tumor to survive.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-52
32323858-4	2020	Furthermore, hypoxia-inducible factor-1alpha (HIF-1alpha) is sensitive to variations in partial oxygen pressure.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-44
32005500-4	2020	We found that the survival rate of the oxygen-glucose deprivation (OGD) neurons was increased after CART treatment.	Oxygen	39-45	CART prepropeptide	Homo sapiens	100-104
32323858-4	2020	Furthermore, hypoxia-inducible factor-1alpha (HIF-1alpha) is sensitive to variations in partial oxygen pressure.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
31654225-0	2020	Dexmedetomidine Protects Against Oxygen-Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway.	Oxygen	33-39	mechanistic target of rapamycin kinase	Homo sapiens	122-126
31954278-6	2020	The oxygen consumption parameters were positively correlated only with the LSV data measured with anodic current between 100 and 1200 mV (LSV1200mV) and with the FRAP index.	Oxygen	4-10	mechanistic target of rapamycin kinase	Homo sapiens	162-166
32550602-10	2020	The increased fraction of NO3 - from 365 nm to around 427 nm results from the competition between the oxygen evolution reaction (OER) at W sites without oxygen vacancies and the N2 oxidation reaction (NOR) at oxygen vacancy sites, which is driven by the intrinsically delocalized photoexcited holes.	Oxygen	102-108	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
32485834-2	2020	Insufficient supply of oxygen and/or nutrients upregulates factors such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), which can induce abnormal angiogenesis and damage the structural arrangement of the retinal blood barrier (BRB).	Oxygen	23-29	vascular endothelial growth factor A	Homo sapiens	75-109
32485834-2	2020	Insufficient supply of oxygen and/or nutrients upregulates factors such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), which can induce abnormal angiogenesis and damage the structural arrangement of the retinal blood barrier (BRB).	Oxygen	23-29	vascular endothelial growth factor A	Homo sapiens	111-115
32220496-2	2020	The mechanism of hypoxia-induced resistance is primarily associated with hypoxia-inducible factor 1alpha (HIF-1alpha), which is an oxygen-sensitive transcriptional activator coordinating the cellular response to hypoxia.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-104
32550602-10	2020	The increased fraction of NO3 - from 365 nm to around 427 nm results from the competition between the oxygen evolution reaction (OER) at W sites without oxygen vacancies and the N2 oxidation reaction (NOR) at oxygen vacancy sites, which is driven by the intrinsically delocalized photoexcited holes.	Oxygen	153-159	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
32220496-2	2020	The mechanism of hypoxia-induced resistance is primarily associated with hypoxia-inducible factor 1alpha (HIF-1alpha), which is an oxygen-sensitive transcriptional activator coordinating the cellular response to hypoxia.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
32550602-10	2020	The increased fraction of NO3 - from 365 nm to around 427 nm results from the competition between the oxygen evolution reaction (OER) at W sites without oxygen vacancies and the N2 oxidation reaction (NOR) at oxygen vacancy sites, which is driven by the intrinsically delocalized photoexcited holes.	Oxygen	153-159	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
32565874-6	2020	Moreover, O. indicum also suppressed LPS plus IFN-gamma-activated reactive oxygen species generation in RAW264.7 macrophages.	Oxygen	75-81	interferon gamma	Mus musculus	46-55
32481626-1	2020	The reduction of oxygen partial pressure in growing tumors triggers numerous survival strategies driven by the transcription factor complex HIF1 (Hypoxia Inducible Factor-1).	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-144
32481626-1	2020	The reduction of oxygen partial pressure in growing tumors triggers numerous survival strategies driven by the transcription factor complex HIF1 (Hypoxia Inducible Factor-1).	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-172
31704414-4	2020	A simplified mechanistic model was developed to describe the enzymatic reaction of glucose oxidase and glucose in the presence of catalase inside a commercial microfluidic platform with integrated oxygen sensor spots.	Oxygen	197-203	catalase	Homo sapiens	130-138
31881285-0	2020	Microbiome changes and oxidative capability of an anaerobic PCB dechlorinating enrichment culture after oxygen exposure.	Oxygen	104-110	pyruvate carboxylase	Homo sapiens	60-63
32553077-0	2020	Hyperbaric Oxygen Treatment Improves Hearing Level via Attenuating TLR4/NF-kappaB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients.	Oxygen	11-17	nuclear factor kappa B subunit 1	Homo sapiens	72-81
32466320-7	2020	Taken together, a novel selective 11beta-HSD1 inhibitor can prevent BAC-induced dry eye syndrome by inhibiting pro-inflammatory cytokine and reactive oxygen species expression via the inhibition of both 11beta-HSD1 activity and expression.	Oxygen	150-156	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	34-45
32061681-1	2020	We recently reported that constitutive ablation of cyclophilin-D (Cyp-D) in mice reduces oxygen consumption (VO2) while paradoxically increasing exercise endurance, thereby demonstrating increased O2 utilization efficiency.	Oxygen	89-95	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	51-64
32159322-7	2020	The presence of only 2.1 mol % O3 in the inlet O2 gas stream can trap 1-2 times more conduction band electrons than pure O2 and shifts the reaction pathway from inefficient three-electron reduction of O2 (O2    O2-   HO2    H2O2    OH) to more efficient one-electron reduction of O3 (O3    O3-   HO3     OH), thereby increasing the yield of  OH by a factor of 17.	Oxygen	47-49	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	280-306
32035098-5	2020	Importantly, our findings demonstrate that activation of GPR43 using its specific agonist significantly suppressed expression of the following key factors of RA: cytokines, such as interleukin-6 (IL-6), IL-8, high mobility group protein 1 (HMG-1); chemokines, such as monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cellular adhesion molecule 1 (VCAM-1); markers of oxidative stress, such as production of reactive oxygen species (ROS) and 4-hydroxynoneal (4-HNE); degradative enzymes, such as matrix metalloproteinase-3 (MMP-3) and MMP-13; and activation of the nuclear factor-kappaB (NF-kappaB) inflammatory signaling pathway.	Oxygen	468-474	free fatty acid receptor 2	Homo sapiens	57-62
32514479-7	2020	On the other hand, myonectin significantly suppressed RANKL-induced oxygen consumption rate and peroxisome proliferator-activated receptor gamma coactivator-1beta mRNA levels in RAW264.7 cells, although myonectin did not affect these mitochondrial biogenesis parameters in mouse osteoblasts.	Oxygen	68-74	erythroferrone	Mus musculus	19-28
32429142-0	2020	Anti-Inflammatory and Reactive Oxygen Species Suppression through Aspirin Pretreatment to Treat Hyperoxia-Induced Acute Lung Injury in NF-kappaB-Luciferase Inducible Transgenic Mice.	Oxygen	31-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
32429142-12	2020	Thus, the effects of aspirin on the anti-inflammatory response and reactive oxygen species suppressive are hypothesized to occur through the NF-kappaB signaling pathway.	Oxygen	76-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-150
32499803-1	2020	Alternative oxidase (AOX) is a non-energy conserving terminal oxidase in the plant mitochondrial electron transport chain (ETC) that has a lower affinity for oxygen than does cytochrome (cyt) oxidase.	Oxygen	158-164	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	21-24
32499803-10	2020	Overall, the results suggest that AOX plays a beneficial role in low oxygen metabolism, despite its lower affinity for oxygen than cytochrome oxidase.	Oxygen	69-75	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	34-37
32499803-10	2020	Overall, the results suggest that AOX plays a beneficial role in low oxygen metabolism, despite its lower affinity for oxygen than cytochrome oxidase.	Oxygen	119-125	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	34-37
32159799-8	2020	Chronic, physiologically low oxygen exposure (3-8%) increased expression of hypoxia-inducible factor 1alpha and syncytin-1, further increased multi-nucleation of the BeWo cell layer, and decreased barrier permeability only against smaller molecules (457 Da/4,000 Da).	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-107
32159799-8	2020	Chronic, physiologically low oxygen exposure (3-8%) increased expression of hypoxia-inducible factor 1alpha and syncytin-1, further increased multi-nucleation of the BeWo cell layer, and decreased barrier permeability only against smaller molecules (457 Da/4,000 Da).	Oxygen	29-35	endogenous retrovirus group W member 1, envelope	Homo sapiens	112-122
32061681-1	2020	We recently reported that constitutive ablation of cyclophilin-D (Cyp-D) in mice reduces oxygen consumption (VO2) while paradoxically increasing exercise endurance, thereby demonstrating increased O2 utilization efficiency.	Oxygen	89-95	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	66-71
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	110-114	superoxide dismutase 1	Homo sapiens	13-20
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	110-114	NAD(P)H quinone dehydrogenase 1	Homo sapiens	142-146
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	110-114	superoxide dismutase 1	Homo sapiens	13-16
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	191-195	superoxide dismutase 1	Homo sapiens	13-20
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	191-195	NAD(P)H quinone dehydrogenase 1	Homo sapiens	142-146
32409654-0	2020	Cuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer.	Oxygen	45-51	mitogen-activated protein kinase 1	Homo sapiens	100-103
32409654-6	2020	We further demonstrated that the potential mechanisms of CONP-induced cytotoxicity were apoptosis, which was triggered by reactive oxygen species through activation of ERK signaling pathway, and autophagy.	Oxygen	131-137	mitogen-activated protein kinase 1	Homo sapiens	168-171
32477956-2	2020	Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-oxidative responses to survive oxidative stress.	Oxygen	68-74	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
32483451-7	2020	The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2 - ) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2 -  is converted to H2O2 via SOD.	Oxygen	191-195	superoxide dismutase 1	Homo sapiens	13-16
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	Oxygen	60-66	oxidoreductase	Arabidopsis thaliana	67-81
32396576-8	2020	Stepwise linear regression revealed that the variance in the Rlim within the cohort was related to the recovery rates of oxygen consumption ([Formula: see text]), HR at the second minute after INC, and muscle tissue saturation index at exhaustion (R = 0.644).	Oxygen	121-127	ring finger protein, LIM domain interacting	Homo sapiens	61-65
32412544-3	2020	Benzylidenechromanones, naturally occurring oxygen heterocyclic compounds, having capability to inhibit various protein and receptors, have been designed here to block mutant variety of coronavirus main protease enzyme (SARC-CoV-2 Mpro) isolated from 2019-nCoV with the assistance of molecular docking, bioinformatics and molecular electrostatic potential.	Oxygen	44-50	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	231-235
32382022-8	2020	Lenvatinib and Cabozantinib were particularly effective in moderately to poorly differentiated cells with mutated or lacking p53 that have lower basal oxygen consumption rate (OCR), ATP, and maximal respiration capacity than observed in differentiated HCC cells.	Oxygen	151-157	tumor protein p53	Homo sapiens	125-128
32380099-5	2020	The resultant SPC has a high specific surface area of 1336 m2 g-1, a large total pore volume of 0.56 cm3 g-1, interconnected macropores, as well as a high oxygen content of up to 13.2%.	Oxygen	155-161	surfactant protein C	Homo sapiens	14-17
32342760-8	2020	Among 589 participants without diabetes mellitus, the betas (95% CI) for homeostatic model assessment of insulin resistance for each SD higher level were 1.09 (1.03, 1.16) for respiratory event index associated with 4% oxygen desaturation, 0.90 (0.85, 0.96) for minimum oxygen saturation, and 1.07 (1.01, 1.13) for fragmented sleep indices.	Oxygen	219-225	insulin	Homo sapiens	105-112
31972529-7	2020	During the sorption process, some ROX molecules were decomposed into inorganic arsenic and organic metabolites by the reactive oxygen species (ROS) generated during the early stages of the reaction.	Oxygen	127-133	MAX network transcriptional repressor	Homo sapiens	34-37
32342760-8	2020	Among 589 participants without diabetes mellitus, the betas (95% CI) for homeostatic model assessment of insulin resistance for each SD higher level were 1.09 (1.03, 1.16) for respiratory event index associated with 4% oxygen desaturation, 0.90 (0.85, 0.96) for minimum oxygen saturation, and 1.07 (1.01, 1.13) for fragmented sleep indices.	Oxygen	270-276	insulin	Homo sapiens	105-112
31960754-7	2020	These results provide new pharmacological evidence that ALP facilitates neuroprotection via prevention of neuronal oxidative stress and promotion of cell survival signaling pathways.Abbreviations: ABTS: 2,2"-azino-bis-(3-ethylbenzothiazoline-6-sulfonicacid); AD: Alzheimer"s disease; ALP: polysaccharide extracts isolated from Annona muricata leaves; ARE: antioxidant response element; DPPH: 1,1-diphenyl-picrylhydrazyl; DCFH-DA: 2",7"-dichlorofluorescin diacetate; ECL: electrochemiluminescence; ERK: extracellular regulated kinase; FBS: Fetal bovine serum; FITC: fluorescein isothiocyanate; FRAP: ferric reducing antioxidant power; HO-1: Heme oxygenase-1; JNK: c-jun N-terminal kinase; MAPKs: mitogen-activated protein kinases; MDA: malondialdehyde; MMP: mitochondrial membrane potential; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide; NQO1: NAD(P)H:quinine oxidoreductase 1, Nrf2: nuclear factor-E2-related factor 2; PD: parkinson"s disease; PI3K: phosphatidylinositol-3kinase; PVDF: polyvinylidene difluoride; ROS: reactive oxygen species; SOD: Superoxidedismutase; TPTZ: tripydyltriazine.	Oxygen	645-651	alopecia, recessive	Mus musculus	56-59
31769924-2	2020	The anti-oxidant transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been suggested to inhibit reactive oxygen species-mediated NF-kappaB activation.	Oxygen	128-134	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-81
31769924-2	2020	The anti-oxidant transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been suggested to inhibit reactive oxygen species-mediated NF-kappaB activation.	Oxygen	128-134	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
32159384-11	2020	As the precursor O2 is increased to 200 and 2000 ppmv, inorganic nitrogen ions become the dominant chemical group, with NO3- having the most intense ion signal.	Oxygen	17-19	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
32275885-5	2020	We also show that in response to oxygen changes, apoptosis signal-regulating kinase 1 (ASK1) is activated and phosphorylates HDAC6, blocking its ubiquitination by von Hippel-Lindau and subsequent degradation by the proteasome.	Oxygen	33-39	histone deacetylase 6	Mus musculus	125-130
32275885-6	2020	Moreover, depletion of HDAC6 or inhibition of the ASK1/HDAC6 axis protects mice from oxygen-change-induced pathological changes of photoreceptors.	Oxygen	85-91	histone deacetylase 6	Mus musculus	23-28
32275885-6	2020	Moreover, depletion of HDAC6 or inhibition of the ASK1/HDAC6 axis protects mice from oxygen-change-induced pathological changes of photoreceptors.	Oxygen	85-91	histone deacetylase 6	Mus musculus	55-60
31654481-1	2020	PURPOSE: To investigate the short-time effect of intravitreal injections (IVI) of the vascular endothelial growth factor inhibitors ranibizumab and aflibercept on retinal arterial and venous oxygen saturation (SO2a and SO2v), arteriovenous oxygen saturation difference (AVD) and vessel diameter (VDa and VDv) in patients with diabetic macular oedema (DME) and patients with choroidal neovascularization (CNV) due to age-related macular degeneration.	Oxygen	191-197	vascular endothelial growth factor A	Homo sapiens	86-120
31853841-10	2020	VEGF exerts an opposite effect on brown adipose tissue, where VEGF increases oxygen supply and improves energy expenditure inducing the whitening of adipocytes.	Oxygen	77-83	vascular endothelial growth factor A	Homo sapiens	0-4
31853841-10	2020	VEGF exerts an opposite effect on brown adipose tissue, where VEGF increases oxygen supply and improves energy expenditure inducing the whitening of adipocytes.	Oxygen	77-83	vascular endothelial growth factor A	Homo sapiens	62-66
31983298-6	2020	These results suggest that endogenous SA is involved in the CHT-induced stomatal closure via the SA receptor, NPR1.Abbreviations: SA: salicylic acid; ABA: abscisic acid; ROS: reactive oxygen species; NPR1: nonexpresser of pathogenesis-related genes1; CHT: chitosan; DAB: 3,3"-diaminobenzidine.	Oxygen	184-190	natriuretic peptide receptor 1	Homo sapiens	110-114
32323755-3	2020	AMPK indirectly inhibits mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a serine/threonine kinase and central regulator of cell growth and metabolism, which integrates various growth inhibitory signals, such as the depletion of glucose, amino acids, ATP and oxygen.	Oxygen	268-274	mechanistic target of rapamycin kinase	Homo sapiens	25-54
32128917-10	2020	On the one hand, activated Nrf2 regulated reactive oxygen balance, and on the other hand, by regulating the transcription level of TRIM24, it was involved in the regulation of the Wnt pathway to promote the proliferation, invasion and metastasis of ccRCC and the resistance of As2 O3 .	Oxygen	51-57	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
32270716-3	2020	The significance of oxygen on CYP3A4-mediated metabolism seems notable while the regulatory mode of CYP3A4 in the particular case still remains elusive.	Oxygen	20-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
31885284-0	2020	S-100beta in predicting the need of hyperbaric oxygen in CO-induced delayed neurological sequels.	Oxygen	47-53	S100 calcium binding protein A1	Homo sapiens	0-9
31758335-3	2020	In this study, a consortium of bacteria was utilized for determination of biodegradation and removal rates, based on reduction in chemical oxygen demand of a mixture of acetone, propionic acid and hexanoic acid (APH) (all components of F-T wastewater), at an organic loading of 5 and 9.53 g CODL-1.	Oxygen	139-145	acylaminoacyl-peptide hydrolase	Homo sapiens	212-215
32070268-2	2020	The P2X7 receptor (P2X7R), a member of the P2X receptor subfamily of P2 receptors, is a unique molecule that has been shown to affect tumor growth and progression as well as various inflammatory processes, including proliferation of T lymphocytes, release of cytokines, and production of free oxygen radicals.	Oxygen	293-299	purinergic receptor P2X 7	Homo sapiens	4-17
32070268-2	2020	The P2X7 receptor (P2X7R), a member of the P2X receptor subfamily of P2 receptors, is a unique molecule that has been shown to affect tumor growth and progression as well as various inflammatory processes, including proliferation of T lymphocytes, release of cytokines, and production of free oxygen radicals.	Oxygen	293-299	purinergic receptor P2X 7	Homo sapiens	19-24
31981230-0	2020	Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria.	Oxygen	26-32	signal transducer and activator of transcription 3	Homo sapiens	67-72
31981230-2	2020	Mitochondrial STAT3 regulates complex I activity and reactive oxygen species (ROS) production, yet the mechanisms governing its translocation to mitochondria remain poorly understood.	Oxygen	62-68	signal transducer and activator of transcription 3	Homo sapiens	14-19
31549922-6	2020	During Stage 1, oxygen uptake was 37.9 +- 1.5 mL kg-1 min-1 in the TRAD condition and 39.6 +- 1.8 mL kg-1 min-1 in THSL (p = 0.05).	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
32323755-3	2020	AMPK indirectly inhibits mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a serine/threonine kinase and central regulator of cell growth and metabolism, which integrates various growth inhibitory signals, such as the depletion of glucose, amino acids, ATP and oxygen.	Oxygen	268-274	mechanistic target of rapamycin kinase	Homo sapiens	56-60
32060059-4	2020	The signalling mechanism underlying increased degranulation involved Rac2 activation, subsequently resulting in proteinase-activated receptor 2 activation by serine proteinases and enhanced reactive oxygen species production.	Oxygen	199-205	Rac family small GTPase 2	Homo sapiens	69-73
32043704-12	2020	The diverting research unveiled that KISS1 repression eased H2 O2 -caused HTR8 cells injury via mediating PI3K/AKT/mTOR pathway.	Oxygen	63-65	AKT serine/threonine kinase 1	Homo sapiens	111-114
32043704-12	2020	The diverting research unveiled that KISS1 repression eased H2 O2 -caused HTR8 cells injury via mediating PI3K/AKT/mTOR pathway.	Oxygen	63-65	mechanistic target of rapamycin kinase	Homo sapiens	115-119
31603990-8	2020	Meanwhile, our study also showed that the over-expression of cystatin C greatly enhanced caveolin-1 expression, which later increased occludin expression in oxygen-glucose deprivation-exposed brain microvascular endothelial cells.	Oxygen	157-163	cystatin C	Mus musculus	61-71
31603990-8	2020	Meanwhile, our study also showed that the over-expression of cystatin C greatly enhanced caveolin-1 expression, which later increased occludin expression in oxygen-glucose deprivation-exposed brain microvascular endothelial cells.	Oxygen	157-163	occludin	Mus musculus	134-142
32185673-9	2020	In contrast, some wetland plants with high O2 supply system efficiently use NO3- from the soil where nitrification occurs.	Oxygen	43-45	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
31907582-4	2020	It was found that ERK1/2 phosphorylation induced by CsA was highly reduced in the presence of the reactive oxygen species (ROS) scavenger polyethylene glycol-superoxide dismutase (PEG-SOD).	Oxygen	107-113	mitogen-activated protein kinase 3	Homo sapiens	18-24
32311236-3	2020	Owing to its highly electroactive sites with numerous nanoporous networks and plentiful oxygen vacancies, the optimal O-Co0.5 Mo0.5 Se2 could catalyze the hydrogen evolution reaction and oxygen evolution reaction effectively with a low overpotential of  102 and 189 mV, at a current density of 10 mA cm-2 , respectively, and exceptional durability.	Oxygen	88-94	fucosyltransferase 2	Homo sapiens	132-135
32311236-3	2020	Owing to its highly electroactive sites with numerous nanoporous networks and plentiful oxygen vacancies, the optimal O-Co0.5 Mo0.5 Se2 could catalyze the hydrogen evolution reaction and oxygen evolution reaction effectively with a low overpotential of  102 and 189 mV, at a current density of 10 mA cm-2 , respectively, and exceptional durability.	Oxygen	187-193	fucosyltransferase 2	Homo sapiens	132-135
32981284-6	2020	Results: Under hypoxia condition, the expression of HIF-1alpha in MCF-7 and BT-20 cells was much higher than that under normal oxygen(P<0.05).	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
31669521-2	2020	Transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply.	Oxygen	228-234	transforming growth factor beta 1	Homo sapiens	0-31
32067150-4	2020	The results indicated decreases in the levels of miR-126-3p and miR-126-5p expression in mice and gerbils after I-R, consistent with the results after oxygen and glucose deprivation and reperfusion (OGD/R) in PC12 cells.	Oxygen	151-157	microRNA 126a	Mus musculus	49-56
32012382-8	2020	In addition, miR-137 modulates mitochondrial dynamics by inducing mitochondrial fusion and fission events, resulting in increased mitochondrial content and activation of oxidative phosphorylation (OXPHOS) and oxygen consumption rate (OCR).	Oxygen	209-215	microRNA 137	Homo sapiens	13-20
32113683-4	2020	High oxygen exposure for three consecutive weeks increased the levels of Grx1 in the lungs of hyperoxic mice from control levels, while Grx1 levels in Grx1 knockout (KO) mice were significantly reduced under high oxygen conditions.	Oxygen	5-11	glutaredoxin	Mus musculus	73-77
32113683-4	2020	High oxygen exposure for three consecutive weeks increased the levels of Grx1 in the lungs of hyperoxic mice from control levels, while Grx1 levels in Grx1 knockout (KO) mice were significantly reduced under high oxygen conditions.	Oxygen	213-219	glutaredoxin	Mus musculus	136-140
32113683-4	2020	High oxygen exposure for three consecutive weeks increased the levels of Grx1 in the lungs of hyperoxic mice from control levels, while Grx1 levels in Grx1 knockout (KO) mice were significantly reduced under high oxygen conditions.	Oxygen	213-219	glutaredoxin	Mus musculus	136-140
32113683-5	2020	Exposure to 85% oxygen for 21 days reduced alveolarization in wild-type (WT) mice but increased the numbers of alveoli and the survival rate of Grx1 KO littermates.	Oxygen	16-22	glutaredoxin	Mus musculus	144-148
31773793-9	2020	The combination of ESI/APPI favors hydrocarbons and oxygen containing species.	Oxygen	52-58	amyloid beta precursor protein	Homo sapiens	23-27
32360463-7	2020	According to the obtained data, Cro inhibits SOD activity by scavenging superoxide radical (O2), while Crt inhibits SOD by affecting the copper-binding site.	Oxygen	92-94	superoxide dismutase 1	Homo sapiens	45-48
32196307-1	2020	Nanozymatic reactions that produce or consume oxygen (O2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity.	Oxygen	46-52	superoxide dismutase 1	Homo sapiens	123-143
32196307-1	2020	Nanozymatic reactions that produce or consume oxygen (O2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity.	Oxygen	46-52	superoxide dismutase 1	Homo sapiens	145-148
32267265-9	2020	The formation of O+ and ArO+ involves direct abstraction of O- from O2 by Ar2+.	Oxygen	68-70	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	24-27
32196307-1	2020	Nanozymatic reactions that produce or consume oxygen (O2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity.	Oxygen	54-56	superoxide dismutase 1	Homo sapiens	123-143
32196307-1	2020	Nanozymatic reactions that produce or consume oxygen (O2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity.	Oxygen	54-56	superoxide dismutase 1	Homo sapiens	145-148
32368190-12	2020	The knock down of NEK10 resulted further in changes in mitochondrial reactive oxygen species (ROS) levels, decreased citrate synthase activity, and culminated in inhibition of mitochondrial respiration, affecting particularly ATP-linked oxygen consumption rate and spare capacity.	Oxygen	78-84	NIMA related kinase 10	Homo sapiens	18-23
32367699-11	2020	Conclusion: As Hb plays an important role in oxygen transport, low levels of Hb and especially MCH may cause increased vascular endothelial growth factor secretion from the hypoxic retina, thereby causing ROP.	Oxygen	45-51	vascular endothelial growth factor A	Homo sapiens	119-153
32391042-8	2020	Functional enrichment analysis showed that up-regulated DEGs and DELs" targets, including LDHA, PFKP, and VEGFA, were significantly enriched in biological processes related to hypoxia or oxygen levels, and the downregulated DEGs and DELs" targets were significantly enriched in extracellular-matrix-related biological processes.	Oxygen	187-193	lactate dehydrogenase A	Homo sapiens	90-94
32391042-8	2020	Functional enrichment analysis showed that up-regulated DEGs and DELs" targets, including LDHA, PFKP, and VEGFA, were significantly enriched in biological processes related to hypoxia or oxygen levels, and the downregulated DEGs and DELs" targets were significantly enriched in extracellular-matrix-related biological processes.	Oxygen	187-193	vascular endothelial growth factor A	Homo sapiens	106-111
32346399-0	2020	EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells.	Oxygen	69-75	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
31923903-0	2020	Theoretical study of oxygen insertion and diffusivity in the g-TiAl L10 system.	Oxygen	21-27	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	68-71
31923903-1	2020	This work is a first-principles study of the insertion and diffusivity of oxygen in the [Formula: see text]-TiAl L10 system.	Oxygen	74-80	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	113-116
32377332-2	2020	As a cellular oxygen sensor, prolyl hydroxylase domain containing protein 2 (PHD2, encoded by egl-9 family hypoxia inducible factor 1, EGLN1) modifies hypoxia-inducible factor alpha (HIF-alpha) protein for proteasomal destruction under normoxic condition.	Oxygen	14-20	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-75
32377332-2	2020	As a cellular oxygen sensor, prolyl hydroxylase domain containing protein 2 (PHD2, encoded by egl-9 family hypoxia inducible factor 1, EGLN1) modifies hypoxia-inducible factor alpha (HIF-alpha) protein for proteasomal destruction under normoxic condition.	Oxygen	14-20	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
32377332-2	2020	As a cellular oxygen sensor, prolyl hydroxylase domain containing protein 2 (PHD2, encoded by egl-9 family hypoxia inducible factor 1, EGLN1) modifies hypoxia-inducible factor alpha (HIF-alpha) protein for proteasomal destruction under normoxic condition.	Oxygen	14-20	egl-9 family hypoxia inducible factor 1	Homo sapiens	135-140
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Oxygen	47-53	egl-9 family hypoxia inducible factor 1	Homo sapiens	69-73
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Oxygen	47-53	iron responsive element binding protein 2	Homo sapiens	123-164
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Oxygen	47-53	iron responsive element binding protein 2	Homo sapiens	166-170
31981873-2	2020	The oxygen-17 excess of nitrate (Delta17O(NO3-)) can be used to reveal the relative importance of nitrate formation pathways and get more insight into reactive nitrogen chemistry.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
32191862-1	2020	The folding reaction of a stable monomeric variant of Cu/Zn superoxide dismutase (mSOD1), an enzyme responsible for the conversion of superoxide free radicals into hydrogen peroxide and oxygen, is known to be among the slowest folding processes that adhere to two-state behavior.	Oxygen	186-192	superoxide dismutase 1	Homo sapiens	54-80
32191862-1	2020	The folding reaction of a stable monomeric variant of Cu/Zn superoxide dismutase (mSOD1), an enzyme responsible for the conversion of superoxide free radicals into hydrogen peroxide and oxygen, is known to be among the slowest folding processes that adhere to two-state behavior.	Oxygen	186-192	superoxide dismutase 1, soluble	Mus musculus	82-87
32290750-0	2020	Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants.	Oxygen	21-27	troponin T2, cardiac type	Homo sapiens	125-130
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Oxygen	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Oxygen	63-66	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	10-17
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Oxygen	63-66	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	10-16
31960561-4	2020	Quasi-in-situ solid state NMR detects C 2 species of acetyl [-COCH 3 ] bonding with an oxygen, ethyl [-CH 2 CH 3 ] bonding with a Zn site, and epoxyethane molecules adsorbing on a Zn site and a Bronsted acid site of the catalyst, respectively.	Oxygen	87-93	cochlin	Homo sapiens	62-66
32227905-1	2020	A copper-catalyzed approach was disclosed for C(sp3)-C(sp2) bond formation via an alpha-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp3)-N bond, wherein O2 served as a green oxidant.	Oxygen	207-209	Sp2 transcription factor	Homo sapiens	53-58
32308987-12	2020	Results: The percentage of change in time until exhaustion and in maximum oxygen consumption was higher in the PBMT/sMF + PBMT/sMF group than in the Placebo+Placebo group at all time-points (p < 0.05).	Oxygen	74-80	small nuclear ribonucleoprotein polypeptide F	Homo sapiens	111-119
31701138-3	2020	We first replicated earlier findings by showing that repetition of target color and of target location from the immediately preceding trial both result in reduced blood oxygen level-dependent (BOLD) signals in a cortical network that encompasses occipital, parietal, and frontal cortices: lag-1 repetition suppression.	Oxygen	169-175	ceramide synthase 1	Homo sapiens	289-294
32308987-12	2020	Results: The percentage of change in time until exhaustion and in maximum oxygen consumption was higher in the PBMT/sMF + PBMT/sMF group than in the Placebo+Placebo group at all time-points (p < 0.05).	Oxygen	74-80	small nuclear ribonucleoprotein polypeptide F	Homo sapiens	122-130
32714599-9	2020	Both oxygen changes caused barriers to release factors that decreased GluN1, GABAAalpha1 staining and increased GluN3a staining.	Oxygen	5-11	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	70-75
32269223-2	2020	Here, we report a H2O2/O2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA).	Oxygen	20-22	moesin	Homo sapiens	53-56
32269223-4	2020	The exposed CaO2 reacts with water to produce O2 and H2O2 for hypoxia-relieved ICG-mediated PDT and H2O2-supplying MSN-based CDT, acting as an open source strategy for ROS production.	Oxygen	14-16	moesin	Homo sapiens	115-118
32328497-8	2020	Flavonoids compete for the oxygen provided by the heme moiety of aromatase in the course of aromatase-catalyzed conversion of steroid precursors to estrogens.	Oxygen	27-33	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	65-74
32328497-8	2020	Flavonoids compete for the oxygen provided by the heme moiety of aromatase in the course of aromatase-catalyzed conversion of steroid precursors to estrogens.	Oxygen	27-33	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	92-101
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Oxygen	165-171	F-box and leucine rich repeat protein 5	Homo sapiens	74-79
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Oxygen	181-187	F-box and leucine rich repeat protein 5	Homo sapiens	64-69
32126207-0	2020	FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.	Oxygen	58-64	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
32126207-0	2020	FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.	Oxygen	58-64	iron responsive element binding protein 2	Homo sapiens	16-20
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Oxygen	181-187	F-box and leucine rich repeat protein 5	Homo sapiens	145-150
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Oxygen	142-148	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Oxygen	165-171	iron responsive element binding protein 2	Homo sapiens	96-100
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Oxygen	142-148	iron responsive element binding protein 2	Homo sapiens	72-97
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Oxygen	142-148	iron responsive element binding protein 2	Homo sapiens	99-103
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Oxygen	181-187	iron responsive element binding protein 2	Homo sapiens	162-166
31967857-0	2020	Carotid body Type I cells engage flavoprotein and Pin1 for oxygen sensing.	Oxygen	59-65	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	50-54
31556366-8	2020	In this article, we discuss the possible involvement of MCU in AD by linking the uniporter to mitochondrial dysfunction, calcium homeostasis, reactive oxygen species, neurotransmitters and the hallmarks of AD - amyloid plaque formation and tau tangle formation.	Oxygen	151-157	mitochondrial calcium uniporter	Homo sapiens	56-59
32126207-5	2020	Interestingly, IRP2 binding to FBXL5 hinges on the oxidized state of the [2Fe2S] cluster maintained by ambient oxygen, which could explain hypoxia-induced IRP2 stabilization.	Oxygen	111-117	iron responsive element binding protein 2	Homo sapiens	15-19
32126207-5	2020	Interestingly, IRP2 binding to FBXL5 hinges on the oxidized state of the [2Fe2S] cluster maintained by ambient oxygen, which could explain hypoxia-induced IRP2 stabilization.	Oxygen	111-117	F-box and leucine rich repeat protein 5	Homo sapiens	31-36
32126207-5	2020	Interestingly, IRP2 binding to FBXL5 hinges on the oxidized state of the [2Fe2S] cluster maintained by ambient oxygen, which could explain hypoxia-induced IRP2 stabilization.	Oxygen	111-117	iron responsive element binding protein 2	Homo sapiens	155-159
32171979-7	2020	The NSAPP pathway is an oxide transport chain that begins when insulin stimulates NADPH oxidase-4 to generate superoxide (O2 -).	Oxygen	122-126	insulin	Homo sapiens	63-70
31659561-11	2020	In addition, FCPR16 decreased the expression of inducible nitric oxide synthase and the production of reactive oxygen species in HT-22 cells exposed to TNF-alpha.	Oxygen	111-117	tumor necrosis factor	Mus musculus	152-161
31956982-6	2020	Foxa1 overexpression increased cell density, cell viability, and easy- and difficult-to-express protein yields, whereas it decreased reactive oxygen species late in fed-batch cultures.	Oxygen	142-148	hepatocyte nuclear factor 3-alpha	Cricetulus griseus	0-5
32112486-5	2020	Additionally, HIF-1alpha-knockdown led to lower mitochondrial membrane potential (DeltaPsim ) and higher reactive oxygen species production in hiPSCs.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
31964469-8	2020	In addition, DL reduced reactive oxygen species either by scavenging them or by activating Nrf2.	Oxygen	33-39	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
31968140-1	2020	The processing of intracellular reactive oxygen species (ROS) by nuclear factor erythroid-derived 2-like 2 (Nrf2) and NADPH quinone oxidoreductase 1 (Nqo1) is important for tumor metastasis.	Oxygen	41-47	NFE2 like bZIP transcription factor 2	Homo sapiens	65-106
31968140-1	2020	The processing of intracellular reactive oxygen species (ROS) by nuclear factor erythroid-derived 2-like 2 (Nrf2) and NADPH quinone oxidoreductase 1 (Nqo1) is important for tumor metastasis.	Oxygen	41-47	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
31968140-1	2020	The processing of intracellular reactive oxygen species (ROS) by nuclear factor erythroid-derived 2-like 2 (Nrf2) and NADPH quinone oxidoreductase 1 (Nqo1) is important for tumor metastasis.	Oxygen	41-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	118-148
31968140-1	2020	The processing of intracellular reactive oxygen species (ROS) by nuclear factor erythroid-derived 2-like 2 (Nrf2) and NADPH quinone oxidoreductase 1 (Nqo1) is important for tumor metastasis.	Oxygen	41-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	150-154
31868937-0	2020	Inhibition of microRNA-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signaling.	Oxygen	42-48	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
31955862-11	2020	Further, DPP4 and METTL7A differentially activated prosurvival signaling pathways including PI3K/AKT, ERK1/2 and STAT3, and attenuated the accumulation of reactive oxygen species (ROS) in choriocarcinoma cell lines.	Oxygen	164-170	methyltransferase like 7A	Homo sapiens	18-25
31930988-14	2020	Cells with LKB1 knockdown had a reduced rate of oxygen consumption, which was partially restored by PDK4 inhibition with dichloroacetate.	Oxygen	48-54	serine/threonine kinase 11	Mus musculus	11-15
32014499-4	2020	DKK-1 was upregulated by Ang II, which was weakened by the Ang II type 1 receptor (AT1R) blocker, reactive oxygen species (ROS) scavenger, and p38 inhibitor.	Oxygen	107-113	angiotensinogen	Homo sapiens	25-31
31838664-6	2020	The direct measurement of the reactive oxygen species by 2,7-Dichlorodihydrofluorescein diacetate confirmed the antioxidant activity of P53 in the vasculature.	Oxygen	39-45	tumor protein p53	Homo sapiens	136-139
31838664-7	2020	Furthermore, the increased reactive oxygen species production due to P53 suppression was associated with lung hyperpermeability responses.	Oxygen	36-42	tumor protein p53	Homo sapiens	69-72
31838664-8	2020	In conclusion, P53 supports endothelial barrier function, at least in part, via the modulation of the reactive oxygen species.	Oxygen	111-117	tumor protein p53	Homo sapiens	15-18
32168447-4	2020	The conversion of 1-trans to 2-trans proceeds via the intermediate formation of an iron(III)-superoxide species 3, which could be trapped and spectroscopically characterized at -50  C. Surprisingly, 3 is a stronger oxygen atom transfer (OAT) agent than 2-trans; 3 performs OAT to 1-trans or PPh3 to yield 2-trans quantitatively.	Oxygen	215-221	caveolin 1	Homo sapiens	291-295
31728053-3	2020	Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of the response to decreased oxygen levels.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
31926875-4	2020	Furthermore, reactive oxygen species have been found to play a crucial role among pathogenesis of TB infection in diabetics (DM-TB) through regulating inflammasome activation and the production of IL-1beta, which in turn modulates the inflammatory network in TB infection, leading to dysfunctional inflammatory responses and tissue remodeling.	Oxygen	22-28	interleukin 1 beta	Homo sapiens	197-205
30161091-10	2020	Furthermore, significant moderate to strong correlations were found between SIT1 and SIT2 total work and peak oxygen uptake (r = 0.48; r = 0.52, respectively), maximal aerobic power (r = 0.89; r = 0.89, respectively), and respiratory compensation point (r = 0.80; r = 0.78, respectively).	Oxygen	110-116	signaling threshold regulating transmembrane adaptor 1	Homo sapiens	76-80
32364989-6	2020	Lipase (LPL), glutathione peroxidase 3 (GPX3), cathelicidin-2 (CATHL2), ceruloplasmin (CP), and hemoglobin subunit alpha 1 (HBA1) cooperatively played roles in the thermal fitness of dairy buffalo by decreasing heat production and increasing blood oxygen delivery.	Oxygen	248-254	glutathione peroxidase 3	Homo sapiens	14-38
31728053-3	2020	Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of the response to decreased oxygen levels.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
32002772-3	2020	Prdx2 reduces the production of reactive oxygen species and participates in regulating various signaling pathways in neurons by catalyzing hydrogen peroxide (H2O2), thereby protecting neurons against oxidative stress and an inflammatory injury.	Oxygen	41-47	peroxiredoxin 2	Homo sapiens	0-5
32066881-0	2020	The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production.	Oxygen	109-115	BCL2 like 1	Homo sapiens	24-30
32066881-9	2020	In contrast, the use of a BH4 peptide that disrupts the Bcl-xL/VDAC1 complex supports that Bcl-xL by acting on VDAC1 permeability contributes to cell migration through the promotion of reactive oxygen species production by the electron transport chain.	Oxygen	194-200	BCL2 like 1	Homo sapiens	56-62
32123312-5	2020	Metabolite tracing with 13C-glucose and 13C-glutamine following MCT1 inhibitor treatment revealed increased quantities of tricarboxylic acid (TCA) cycle intermediates and increased oxygen consumption rate.	Oxygen	181-187	solute carrier family 16 member 1	Homo sapiens	64-68
32066881-9	2020	In contrast, the use of a BH4 peptide that disrupts the Bcl-xL/VDAC1 complex supports that Bcl-xL by acting on VDAC1 permeability contributes to cell migration through the promotion of reactive oxygen species production by the electron transport chain.	Oxygen	194-200	BCL2 like 1	Homo sapiens	91-97
32529190-7	2020	We also demonstrate that these nanospindles can generate oxygen in the presence of endogenous hydrogen peroxide to inhibit P-glycoprotein expression under hypoxia and can achieve excellent tumor eradication and tumor metastasis inhibition performance.	Oxygen	57-63	ATP binding cassette subfamily B member 1	Homo sapiens	123-137
32063036-10	2020	To conclude, reactive oxygen species in semen is considered to have an adverse effect on both the early and late stages of embryo development in intracytoplasmic sperm injection.Abbreviations: GnRH, gonadotropin-releasing hormone; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; LPO, lipid peroxidation; NADPH, nicotinamide adenine dinucleotide phosphate; RLU, relative light units; ROC, receiver operating characteristic; ROS, reactive oxygen species.	Oxygen	22-28	lactoperoxidase	Homo sapiens	300-303
31813922-7	2020	Since TXNIP is well known to be involved in the production of reactive oxygen species (ROS), we next examined the effect of ChREBP/Mlx co-overexpression, in the absence of glucose, on ROS production in HK-2 cells.	Oxygen	71-77	thioredoxin interacting protein	Mus musculus	6-11
32034035-0	2020	CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.	Oxygen	77-83	cysteine-rich RLK (RECEPTOR-like protein kinase) 2	Arabidopsis thaliana	0-4
32342732-8	2020	Knockdown of A-kinase anchor protein 4 also led to increased reactive oxygen species generation as a result of upregulation of NOXA and CHOP.	Oxygen	70-76	A-kinase anchoring protein 4	Homo sapiens	13-38
32050753-8	2020	Upregulated TRIP-Br1 suppressed necroptosis by repressing reactive oxygen species generation.	Oxygen	67-73	SERTA domain containing 1	Homo sapiens	12-20
32265740-3	2020	Among these channels, TRPML1 is a reactive oxygen species sensor localized on the lysosomal membrane that is able to control intracellular oxidative stress due to the activation of the autophagic process.	Oxygen	43-49	mucolipin TRP cation channel 1	Homo sapiens	22-28
32209682-8	2020	The increased amino acid demand of the fur mutant or iron chelated cells was exacerbated by aerobic conditions, which could be partly explained by the O2-dependent synthesis of the siderophore aerobactin, encoded by an operon within a pathogenicity island.	Oxygen	151-153	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	39-42
32107323-10	2020	Incubation of cultured microglia with sVE-cadherin resulted in increased inducible nitric oxide synthase, interleukin-1beta, reactive oxygen species, cell soma size, and metabolic activity, consistent with microglia activation.	Oxygen	134-140	cadherin 5	Homo sapiens	42-50
31931619-1	2020	NADPH oxidases (NOX-es) produce reactive oxygen species and modulate beta-cell insulin secretion.	Oxygen	41-47	insulin	Homo sapiens	79-86
32197638-11	2020	Interestingly, VEGF knockdown in 1%O2 MSCs attenuated HGF secretion and the inhibition of TGF-beta1-induced fibrotic changes in HK-2 cells.	Oxygen	35-37	vascular endothelial growth factor A	Homo sapiens	15-19
32118423-3	2020	The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.	Oxygen	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
32197638-11	2020	Interestingly, VEGF knockdown in 1%O2 MSCs attenuated HGF secretion and the inhibition of TGF-beta1-induced fibrotic changes in HK-2 cells.	Oxygen	35-37	transforming growth factor, beta 1	Rattus norvegicus	90-99
32046917-1	2020	The Keap1-Nrf2-ARE system represents a crucial antioxidant defense mechanism that protects cells against reactive oxygen species.	Oxygen	114-120	kelch like ECH associated protein 1	Homo sapiens	4-9
32183695-2	2020	Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 alpha post-translational modification system.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-106
31884782-7	2020	The intracellular reactive oxygen species production of NI-Por NPs and NI-ZnPor NPs was confirmed using DCFH-DA as an indicator.	Oxygen	27-33	cytochrome p450 oxidoreductase	Homo sapiens	59-62
32046917-1	2020	The Keap1-Nrf2-ARE system represents a crucial antioxidant defense mechanism that protects cells against reactive oxygen species.	Oxygen	114-120	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
32226385-2	2020	Inflammation, in particular interleukin-1beta (IL-1beta), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP.	Oxygen	171-177	interleukin 1 beta	Rattus norvegicus	28-45
32292509-7	2020	The mechanism of TNF-driven T cell death involves TNFR2 and production of mitochondrial oxygen free radicals which damage DNA.	Oxygen	88-94	tumor necrosis factor	Homo sapiens	17-20
32226385-2	2020	Inflammation, in particular interleukin-1beta (IL-1beta), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP.	Oxygen	171-177	interleukin 1 alpha	Rattus norvegicus	47-55
31883459-5	2020	Under irradiation, BTZ@ZnPc-ALN could generate reactive oxygen species (ROS) to cause mitochondrial damage, and increase the cytosolic Ca2+ levels and the expression of GRP78 protein to induce excessive endoplasmic reticulum (ER) stress, thereby synergistically inhibiting cell proliferation.	Oxygen	56-62	heat shock protein family A (Hsp70) member 5	Homo sapiens	169-174
32123892-2	2020	It was found that Fe atoms were strongly anchored at the sp-C vacancy site of alpha-graphyne with a large binding energy of -5.28 eV and effectively adsorbed and activated O2 molecules.	Oxygen	172-174	surfactant protein C	Homo sapiens	57-61
31985487-5	2020	We identify mitochondrial trifunctional protein-alpha (MTPalpha) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTPalpha.	Oxygen	187-193	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	55-63
32150252-9	2020	Our findings also demonstrate that exposure to 1% O2 or to Roxa increases the expression of HIF1alpha, the number of lipid-containing vesicles, the content of neutral lipids, and the activity of DNase II and decreases the pH in IHMGECs in vitro.	Oxygen	50-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-101
32152275-6	2020	Exposure to 1% O2 induced HIF1A protein and reduced miR-100-5p expression, while HIF1A silencing dramatically rescued miR-100-5p expression upon 1% O2 exposure.	Oxygen	15-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
32152275-6	2020	Exposure to 1% O2 induced HIF1A protein and reduced miR-100-5p expression, while HIF1A silencing dramatically rescued miR-100-5p expression upon 1% O2 exposure.	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-86
32152275-7	2020	In addition, 1% O2-induced increases in lactate concentration and glucose uptake were also suppressed by HIF1A silencing.	Oxygen	16-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
32201801-1	2020	Both theory and experiment show that sp2 carbon nanomaterials doped with N have great potential as high-efficiency catalysts for oxygen reduction reactions (ORR).	Oxygen	129-135	Sp2 transcription factor	Homo sapiens	37-40
32036249-6	2020	SLC7A11-AS1 promotes chemoresistance through reducing intracellular reactive oxygen species (ROS) by stabilizing nuclear factor erythroid-2-related factor 2 (NRF2), the key regulator in antioxidant defense.	Oxygen	77-83	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
32215176-16	2020	Our findings demonstrate that TRPM7 knockdown promotes HIF-1alpha degradation via an oxygen-independent mechanism involving increased binding of RAKC1 to HIF-1alpha, and TRPM7-HIF-1alpha-Annexin A1 signaling axis plays a crucial role in the EMT, cell migration, and invasion of androgen-independent prostate cancer cells under hypoxic conditions.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
31985487-5	2020	We identify mitochondrial trifunctional protein-alpha (MTPalpha) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTPalpha.	Oxygen	187-193	glucagon	Homo sapiens	138-143
31985487-5	2020	We identify mitochondrial trifunctional protein-alpha (MTPalpha) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTPalpha.	Oxygen	233-239	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	55-63
31985487-5	2020	We identify mitochondrial trifunctional protein-alpha (MTPalpha) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTPalpha.	Oxygen	233-239	glucagon	Homo sapiens	89-94
31985487-5	2020	We identify mitochondrial trifunctional protein-alpha (MTPalpha) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTPalpha.	Oxygen	233-239	glucagon	Homo sapiens	138-143
31797403-0	2020	Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2-related factor 2 activation.	Oxygen	59-65	NFE2 like bZIP transcription factor 2	Homo sapiens	95-138
31904285-0	2020	Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats.	Oxygen	48-54	angiotensinogen	Rattus norvegicus	14-28
31904285-7	2020	Ang II decreased oxygen consumption in mitochondria from both control and diabetic rats.	Oxygen	17-23	angiotensinogen	Rattus norvegicus	0-6
31904285-8	2020	Ang II response was reversed to increased oxygen consumption by nitric oxide synthase inhibitor L-NAME.	Oxygen	42-48	angiotensinogen	Rattus norvegicus	0-6
32293153-8	2020	It reveals that NIR-LED inhibits the production of reactive oxygen species by regulating the Nox4-NF-kappaB pathway.	Oxygen	60-66	nuclear factor kappa B subunit 1	Homo sapiens	98-107
31865141-12	2020	Importantly, we found that CRBN knockdown-ameliorated inflammatory response was markedly abrogated by the pre-treatment of Nrf-2 inhibitor and ER stress activator, suggesting that CRBN-regulated inflammation in ALI was partly through the meditation of reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress.	Oxygen	261-267	cereblon	Mus musculus	27-31
31740404-0	2020	PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.	Oxygen	101-107	platelet factor 4	Mus musculus	0-3
31865141-12	2020	Importantly, we found that CRBN knockdown-ameliorated inflammatory response was markedly abrogated by the pre-treatment of Nrf-2 inhibitor and ER stress activator, suggesting that CRBN-regulated inflammation in ALI was partly through the meditation of reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress.	Oxygen	261-267	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-128
31865141-12	2020	Importantly, we found that CRBN knockdown-ameliorated inflammatory response was markedly abrogated by the pre-treatment of Nrf-2 inhibitor and ER stress activator, suggesting that CRBN-regulated inflammation in ALI was partly through the meditation of reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress.	Oxygen	261-267	cereblon	Mus musculus	180-184
31777134-7	2020	LETM1 suppression did not alter the expression of OXPHOS complexes, but the oxygen consumption rates decreased significantly; however, this change was not related to complex I but instead involved complex IV and complex II.	Oxygen	76-82	leucine zipper-EF-hand containing transmembrane protein 1	Mus musculus	0-5
31902637-1	2020	Denitratation (NO3- NO2-)/anammox is a promising method for anammox application in mainstream wastewater treatment plants (WWTPs) to reduce oxygen and organic matter consumption.	Oxygen	140-146	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF superfamily member 10	Homo sapiens	18-23
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF superfamily member 10	Homo sapiens	31-36
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	mitogen-activated protein kinase 8	Homo sapiens	113-116
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	mitogen-activated protein kinase 8	Homo sapiens	118-141
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF superfamily member 10	Homo sapiens	25-30
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF superfamily member 10	Homo sapiens	278-283
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF superfamily member 10	Homo sapiens	25-30
31794767-6	2020	S100 proteins are released from monocytes, smooth muscle cells and endothelial cells in response to cellular stress stimuli, and then the binding of S100 proteins to RAGE activate downstream signaling such as transcription factor kappa B (NF-kappaB) translocation and reactive oxygen species (ROS) production, which act as a positive feedback loop for inducing pro-inflammatory phenotype in a wide variety of cell types including endothelial cells, vascular smooth muscle cells and leukocytes.	Oxygen	277-283	S100 calcium binding protein B	Homo sapiens	0-4
31794767-6	2020	S100 proteins are released from monocytes, smooth muscle cells and endothelial cells in response to cellular stress stimuli, and then the binding of S100 proteins to RAGE activate downstream signaling such as transcription factor kappa B (NF-kappaB) translocation and reactive oxygen species (ROS) production, which act as a positive feedback loop for inducing pro-inflammatory phenotype in a wide variety of cell types including endothelial cells, vascular smooth muscle cells and leukocytes.	Oxygen	277-283	S100 calcium binding protein B	Homo sapiens	149-153
31904099-6	2020	Additionally, the levels of C-reactive protein (CRP), proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha), and reactive oxygen species (ROS) were significantly increased in the IR/R and IR/gammaR groups compared to the control group.	Oxygen	125-131	insulin receptor-related receptor	Rattus norvegicus	182-193
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	Oxygen	255-261	nuclear receptor subfamily 1, group H, member 3	Mus musculus	197-200
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	RUNX family transcription factor 2	Homo sapiens	76-81
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	bone gamma-carboxyglutamate protein	Homo sapiens	88-93
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	CCAAT enhancer binding protein alpha	Homo sapiens	137-142
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	peroxisome proliferator activated receptor gamma	Homo sapiens	144-149
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	adiponectin, C1Q and collagen domain containing	Homo sapiens	155-161
31855674-0	2020	Oxygen mobility and microstructure properties-redox performance relationship of Rh/(Ce,Zr,La)O2 catalysts.	Oxygen	0-6	Rh blood group CcEe antigens	Homo sapiens	80-95
31944416-1	2020	The HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1alpha and HIF-2alpha.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
31593329-1	2020	Catalase is a widespread heme-containing enzyme, which converts hydrogen peroxide (H2 O2 ) to water and molecular oxygen, thereby protecting cells from the toxic effects of H2 O2 .	Oxygen	114-120	catalase	Homo sapiens	0-8
31887331-3	2020	HIF-1alpha maintains oxygen homeostasis by inducing glycolysis, erythropoiesis, and angiogenesis.	Oxygen	21-27	hypoxia inducible factor 1 alpha subunit	Gallus gallus	0-10
31985025-3	2020	Furthermore, the inhibitory role of ligustrazine on the upregulation of NOD2 and apoptosis of kidney cells induced by CoCl2 and oxygen and glucose deprivation followed by reoxygenation was investigated in in vitro experiments.	Oxygen	128-134	nucleotide-binding oligomerization domain containing 2	Rattus norvegicus	72-76
32147983-6	2020	The mean ROX index (the ratio of SpO2 divided by fraction of inspired oxygen to respiratory rate) at 6 hours of the weaned group was 12.3 versus 9.3 in the ongoing HFNC group, and 8.5 in the reintubated group (P = 0.02).	Oxygen	70-76	MAX network transcriptional repressor	Homo sapiens	9-12
31860779-6	2020	There is evidence for the involvement of reactive oxygen species (ROS) in Cd-induced ERK1/2 activation.	Oxygen	50-56	mitogen-activated protein kinase 3	Homo sapiens	85-91
31957111-5	2020	Furthermore, we found that NaB inhibited migration and induced AMPK/mTOR pathway-activated autophagy and reactive oxygen species (ROS) overproduction via the miR-139-5p/Bmi-1 axis.	Oxygen	114-120	mechanistic target of rapamycin kinase	Homo sapiens	68-72
31933392-2	2020	We previously showed that 27-hydroxycholesterol (27HC) promoted the invasion and migration of breast cancer cells and activated signal transducer and activator of transcription 3 (STAT-3) signaling through reactive oxygen species (ROS).	Oxygen	215-221	signal transducer and activator of transcription 3	Homo sapiens	128-178
31933392-2	2020	We previously showed that 27-hydroxycholesterol (27HC) promoted the invasion and migration of breast cancer cells and activated signal transducer and activator of transcription 3 (STAT-3) signaling through reactive oxygen species (ROS).	Oxygen	215-221	signal transducer and activator of transcription 3	Homo sapiens	180-186
31700166-9	2020	Moreover, the administration of LDN significantly reduced Ang II-induced left atrial dilation, fibrosis, inflammatory cell infiltration, and reactive oxygen species (ROS) production.	Oxygen	150-156	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	58-64
31889412-9	2020	Overexpression of miR-27a or miR-142-5p suppressed the expression of Nrf2 and its downstream antioxidant genes and increased production of reactive oxygen species, whereas inhibition of miR-27a or miR-142-5p reversed these effects.	Oxygen	148-154	microRNA 27a	Homo sapiens	18-25
31889412-9	2020	Overexpression of miR-27a or miR-142-5p suppressed the expression of Nrf2 and its downstream antioxidant genes and increased production of reactive oxygen species, whereas inhibition of miR-27a or miR-142-5p reversed these effects.	Oxygen	148-154	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
31725940-8	2020	Bmi1 overexpression in MSCs also corrected 1,25(OH)2 D deficiency-induced oxidative stress and DNA damage, and cellular senescence of Cyp27b1+/- mice by reducing levels of reactive oxygen species, elevating serum total superoxide dismutase levels, reducing the percentage of gammaH2 A.X, p16, IL-1beta and TNF-alpha positive cells and decreasing gammaH2A.X, p16, p19, p53, p21, IL-1beta and IL-6 expression levels.	Oxygen	181-187	Bmi1 polycomb ring finger oncogene	Mus musculus	0-4
31868637-6	2020	With an initial OTC concentration of 44 muM, after 30 min the removal rates of chemical oxygen demand (COD) by Raw-GF and NaOH-GF were 59.18% and 83.75%, respectively.	Oxygen	88-94	latexin	Homo sapiens	40-43
31659628-11	2020	CCN1 binds to integrin alpha6beta1 to induce autophagy through reactive oxygen species, and the activation of ERK and JNK.	Oxygen	72-78	cellular communication network factor 1	Mus musculus	0-4
32134862-7	2020	RESULTS: LTC at 0.5 to 2 mug/mL significantly increased cell viability and decreased LDH, NO, PGE2, IL-1beta, IL-6, and TNF-alpha production in oxygen-glucose deprivation/reoxygenation (OGD/R) and lipopolysaccharide (LPS)-induced BV2 microglia cells.	Oxygen	144-150	tumor necrosis factor	Mus musculus	120-129
32060587-2	2020	However, prolonged P38 and JNK signalling is associated with damaging inflammatory responses, reactive oxygen species-induced cell death, and fibrosis in multiple tissues, such as the kidney, liver, central nervous system, and cardiopulmonary systems.	Oxygen	103-109	mitogen-activated protein kinase 14	Homo sapiens	19-22
32060587-2	2020	However, prolonged P38 and JNK signalling is associated with damaging inflammatory responses, reactive oxygen species-induced cell death, and fibrosis in multiple tissues, such as the kidney, liver, central nervous system, and cardiopulmonary systems.	Oxygen	103-109	mitogen-activated protein kinase 8	Homo sapiens	27-30
30789095-0	2020	Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis.	Oxygen	90-96	albumin	Homo sapiens	34-41
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Oxygen	126-132	catalase	Homo sapiens	70-78
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	spinster homolog 2	Mus musculus	172-177
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Oxygen	126-132	catalase	Homo sapiens	17-20
31932812-7	2020	Through activation of EGR1, excessive reactive oxygen species in the tumor microenvironment induce expression of PAC1, which recruits the Mi-2beta nucleosome-remodeling and histone-deacetylase complex, eventually leading to chromatin remodeling of effector T cells.	Oxygen	47-53	chromodomain helicase DNA binding protein 4	Homo sapiens	138-146
32194708-9	2020	In addition, rhES had no effect on the proliferation of SW620 cells, suggesting that the reduction in TSP-1 was associated with increased oxygen content during vascular normalization, rather than inhibited cell proliferation.	Oxygen	138-144	thrombospondin 1	Homo sapiens	102-107
31870893-0	2020	MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4.	Oxygen	22-28	AKT serine/threonine kinase 1	Homo sapiens	96-99
32005973-7	2020	Moreover, we found that mitochondrial fusion driven by AIM2 knockdown leads to a decrease of cellular reactive oxygen species (ROS) production, which further causes inactivation of the MAPK/ERK signaling pathway.	Oxygen	111-117	absent in melanoma 2	Homo sapiens	55-59
31831174-2	2020	In this study, we found that RNPS1 expression was significantly up-regulated in the brains of ischemic stroke mice and primary cortical neurons after oxygen-glucose deprivation (OGD) treatment.	Oxygen	150-156	RNA binding protein with serine rich domain 1	Mus musculus	29-34
32146607-0	2020	Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes.	Oxygen	9-15	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	39-52
32146607-0	2020	Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes.	Oxygen	9-15	interleukin 6	Mus musculus	62-66
31899805-3	2020	PSK1 is a nutrient responsive protein kinase involved in regulation of glucose metabolism, sensory response to light, oxygen, and redox state.	Oxygen	118-124	serine/threonine protein kinase PSK1	Saccharomyces cerevisiae S288C	0-4
31907278-2	2020	The master regulators of oxygen homeostasis in mammalian cells are the heterodimeric hypoxia-inducible transcription factors HIF-1 and HIF-2.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-130
32110867-1	2020	During the electric arc furnace steelmaking process, the coherent jet technology was widely used to protect the kinetic energy of the supersonic oxygen jet and achieve better mixing effects.	Oxygen	145-151	F-box and leucine rich repeat protein 15	Homo sapiens	66-69
32102665-0	2020	Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling.	Oxygen	61-67	kelch like ECH associated protein 1	Homo sapiens	0-5
32102665-1	2020	BACKGROUND: Mimicking ischemia-reperfusion injury, oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) applied to endometrial cells produces significant oxidative stress and programmed necrosis, which can be inhibited by nuclear-factor-E2-related factor 2 (Nrf2) signaling.	Oxygen	51-57	NFE2 like bZIP transcription factor 2	Homo sapiens	228-262
32102665-1	2020	BACKGROUND: Mimicking ischemia-reperfusion injury, oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) applied to endometrial cells produces significant oxidative stress and programmed necrosis, which can be inhibited by nuclear-factor-E2-related factor 2 (Nrf2) signaling.	Oxygen	51-57	NFE2 like bZIP transcription factor 2	Homo sapiens	264-268
32110867-1	2020	During the electric arc furnace steelmaking process, the coherent jet technology was widely used to protect the kinetic energy of the supersonic oxygen jet and achieve better mixing effects.	Oxygen	145-151	F-box and leucine rich repeat protein 15	Homo sapiens	152-155
32110867-3	2020	However, there was limited research about the effect of restriction structure for the coherent lance tip on the flow field characteristic of the main oxygen jet.	Oxygen	150-156	F-box and leucine rich repeat protein 15	Homo sapiens	157-160
31822409-7	2020	ZnO NPs addition also induced the dose-dependent variations in the superoxide dismutase (SOD) and catalase (CAT) activities, which probably contributed to the suppression of the excess reactive oxygen species (ROS) generations to mitigate nanotoxicity.	Oxygen	194-200	catalase	Homo sapiens	98-106
32106535-7	2020	Moreover, when applying this method to iPSCs from Alzheimer"s disease (AD) patients with presenilin-1 (PS1) or presenilin-2 (PS2) mutations, cellular phenotypes such as increased amount of extracellular secretion of amyloid beta42, abnormal oxygen consumption, and increased reactive oxygen species in the cells were observed in a shorter culture period than those previously reported.	Oxygen	241-247	presenilin 2	Homo sapiens	125-128
31822409-7	2020	ZnO NPs addition also induced the dose-dependent variations in the superoxide dismutase (SOD) and catalase (CAT) activities, which probably contributed to the suppression of the excess reactive oxygen species (ROS) generations to mitigate nanotoxicity.	Oxygen	194-200	catalase	Homo sapiens	108-111
31937588-0	2020	Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.	Oxygen	0-6	OTU deubiquitinase 7B	Homo sapiens	86-93
31914408-1	2020	Production of reactive oxygen species due to dysregulated endothelial nitric oxide synthase (eNOS) activity is linked to vascular dysfunction.	Oxygen	23-29	nitric oxide synthase 3	Homo sapiens	58-91
31937588-8	2020	They also uncover that this interaction with ubiquitin, and thus with modified substrates, can be modulated by oxygen-dependent asparagine hydroxylation, suggesting that Cezanne is regulated by oxygen levels.	Oxygen	111-117	OTU deubiquitinase 7B	Homo sapiens	170-177
31937588-8	2020	They also uncover that this interaction with ubiquitin, and thus with modified substrates, can be modulated by oxygen-dependent asparagine hydroxylation, suggesting that Cezanne is regulated by oxygen levels.	Oxygen	194-200	OTU deubiquitinase 7B	Homo sapiens	170-177
31937588-3	2020	We demonstrate that Cezanne is a substrate for factor inhibiting HIF1 (FIH1)- and oxygen-dependent asparagine hydroxylation.	Oxygen	82-88	OTU deubiquitinase 7B	Homo sapiens	20-27
31838253-0	2020	lncRNA NR_120420 Promotes SH-SY5Y Cells Apoptosis by Regulating NF-kappaB after Oxygen and Glucose Deprivation.	Oxygen	80-86	nuclear factor kappa B subunit 1	Homo sapiens	64-73
32149226-7	2020	We showed that after the LTAOP treatment, the surfaces of both SM and SLA titanium substrates become more hydrophilic with a larger active oxygen species composition, whereas no obvious morphological changes were observed.	Oxygen	139-145	Src like adaptor	Homo sapiens	70-73
32093169-2	2020	At the same time, the induction of oxygen-dependent molecule expression, in particular, miRNA and erythropoietin, is modulated.	Oxygen	35-41	erythropoietin	Homo sapiens	98-112
32065769-11	2020	Change in VO2peak ranged from -2.7 to 4.1 mL O2 kg-1 min-1 and from -3.6 to 5.1 mL O2 kg-1 min-1 in LET and NLET, respectively.	Oxygen	11-13	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
32071291-4	2020	A series of PD-related cascade events such as ER stress, abnormal calcium homeostasis, mitochondrial dysfunction, increase of reactive oxygen species, and apoptosis were observed in PLA2G6 D331Y mutant DA neurons, whereas azoramide significantly protected PLA2G6 D331Y mutant DA neurons against these events.	Oxygen	135-141	phospholipase A2 group VI	Homo sapiens	182-188
32071294-6	2020	Furthermore, NR1D1 activation reduced reactive oxygen species (ROS) generation and increased the production of nuclear transcription factor E2-related factor 2 (Nrf2)-associated enzymes.	Oxygen	47-53	nuclear receptor subfamily 1 group D member 1	Homo sapiens	13-18
32065781-6	2020	Inhibition of MEG3 remarkably increased the expression of miR-424-5p and decreased the expression of Sema3A, which also led to in an increased cell viability and decreased cellular apoptosis in oxygen-glucose deprivation and reoxygenation (OGD/R) model, as well as an activated MAPK signaling pathways.	Oxygen	194-200	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	14-18
32071354-7	2020	The reduction in mitochondrial PC levels and oxygen consumption rates, decreased expression of myomaker, myomerger and PGC-1alpha, as well as impaired myogenic differentiation, were completely restored when the protein was reintroduced into StarD7-knockout C2C12 cells.	Oxygen	45-51	START domain containing 7	Mus musculus	241-247
32211593-6	2020	Thus, resident disc cells may utilize autophagy and mTOR signaling to cope with harsh low-nutrient conditions, such as low glucose, low oxygen, and low pH.	Oxygen	136-142	mechanistic target of rapamycin kinase	Homo sapiens	52-56
31854058-6	2020	CoxFluor enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protein expression within live macrophage cells.	Oxygen	34-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-67
31590087-6	2020	The transformation of 2-CDD was accompanied by the resale of Cl ion, and the additional oxygen was proven to be able to consume electrons and hydrogen ions, thus greatly inhibiting the degradation of PCDD in systems.	Oxygen	88-94	natriuretic peptide A	Homo sapiens	24-27
32079134-1	2020	An oxygen-free solar selective absorbing coating of Cu/TixSiyN/AlSiN was prepared on a Cu buffered stainless steel substrate by magnetron sputtering.	Oxygen	3-9	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	63-68
31821812-5	2020	Moreover, we show that these two neutralizing mutations, G127V and G127I, significantly decrease the human PrP cytotoxicity resulting from PrP fibril formation, mitochondrial damage, and elevated reactive oxygen species production enhanced by a strong prion-prone peptide PrP 106-126.	Oxygen	205-211	prion protein	Homo sapiens	107-110
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	29-35	Rho guanine nucleotide exchange factor 7	Homo sapiens	4-7
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	139-145	Rho guanine nucleotide exchange factor 7	Homo sapiens	4-7
32116694-6	2020	Nevertheless, miR-96 was significantly downregulated in the retina and choroid of OIR rats (80% O2 from P5 to P10) during the phase of microvascular degeneration.	Oxygen	96-98	microRNA 96	Rattus norvegicus	14-20
32075095-2	2020	Single-crystal X-ray analyses revealed two modes of Hhp ligation in these complexes: a monodentate coordination of carbonyl oxygen in all of them and an additional micro2-oxygen bridging coordination in the dinuclear complex 4.	Oxygen	124-130	IH	Homo sapiens	52-55
32075095-2	2020	Single-crystal X-ray analyses revealed two modes of Hhp ligation in these complexes: a monodentate coordination of carbonyl oxygen in all of them and an additional micro2-oxygen bridging coordination in the dinuclear complex 4.	Oxygen	171-177	IH	Homo sapiens	52-55
32060388-8	2020	In addition, Ocellatin-K1(1-16) and Ocellatin-K1(1-21) were effective in impairing lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) formation and NF-kB activation in living microglia.	Oxygen	125-131	toll-like receptor 4	Mus musculus	103-106
32053878-3	2020	NRF2 is activated in response to oxidative stress by reactive oxygen species (ROS) and electrophiles.	Oxygen	62-68	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32041924-0	2020	microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation.	Oxygen	89-95	microRNA 1203	Homo sapiens	0-13
32041924-0	2020	microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation.	Oxygen	89-95	peptidylprolyl isomerase F	Homo sapiens	35-48
32050585-9	2020	Ang-(1-7) also abolished the increase of myostatin-induced reactive oxygen species production, atrogin-1, MuRF-1, and TNF-alpha gene expressions and NF-kappaB signaling activation.	Oxygen	68-74	myostatin	Homo sapiens	41-50
32046324-7	2020	p38 MAPK contributed to Akt-induced eNOS phosphorylation at Ser1177 that resulted in accelerated NO production and reduced reactive oxygen species production in aortic endothelia.	Oxygen	132-138	thymoma viral proto-oncogene 1	Mus musculus	24-27
31927922-6	2020	This work indicates that, the electrochemical proper-ties of low-doped BDD containing sp2 might be due partially to the high level of surface oxygen, the large work function, the low carrier density and the existence of different types of sp2 carbon.	Oxygen	142-148	Sp2 transcription factor	Homo sapiens	86-89
31939292-5	2020	We employed a combined multiscale approach involving classical atomistic equilibrium and non-equilibrium MD simulations combined with QM/MM trajectories to investigate dioxygen diffusion to, and binding at, the active site in the PHD2.Fe(II).2OG.HIF substrate complex; PHD2 is the most important of the three human PHDs.	Oxygen	168-176	egl-9 family hypoxia inducible factor 1	Homo sapiens	230-234
31939292-6	2020	The transport of dioxygen to the active site is described; dioxygen transport follows a single well-defined hydrophobic tunnel, formed from both enzyme and substrate elements to reach the PHD2 active site.	Oxygen	17-25	egl-9 family hypoxia inducible factor 1	Homo sapiens	188-192
31939292-6	2020	The transport of dioxygen to the active site is described; dioxygen transport follows a single well-defined hydrophobic tunnel, formed from both enzyme and substrate elements to reach the PHD2 active site.	Oxygen	59-67	egl-9 family hypoxia inducible factor 1	Homo sapiens	188-192
31939292-7	2020	The results provide estimates for rate constants that define a diffusion-reaction model for dioxygen:PHD2 interactions; in combination with reported biophysical analyses they provide chemical insight into the basis of the slow reaction of PHD2 with dioxygen.	Oxygen	92-100	egl-9 family hypoxia inducible factor 1	Homo sapiens	101-105
31939292-7	2020	The results provide estimates for rate constants that define a diffusion-reaction model for dioxygen:PHD2 interactions; in combination with reported biophysical analyses they provide chemical insight into the basis of the slow reaction of PHD2 with dioxygen.	Oxygen	92-100	egl-9 family hypoxia inducible factor 1	Homo sapiens	239-243
31939292-7	2020	The results provide estimates for rate constants that define a diffusion-reaction model for dioxygen:PHD2 interactions; in combination with reported biophysical analyses they provide chemical insight into the basis of the slow reaction of PHD2 with dioxygen.	Oxygen	249-257	egl-9 family hypoxia inducible factor 1	Homo sapiens	101-105
31939292-7	2020	The results provide estimates for rate constants that define a diffusion-reaction model for dioxygen:PHD2 interactions; in combination with reported biophysical analyses they provide chemical insight into the basis of the slow reaction of PHD2 with dioxygen.	Oxygen	249-257	egl-9 family hypoxia inducible factor 1	Homo sapiens	239-243
31939292-9	2020	The extent of HIF-alpha substrate prolyl hydroxylation, which signals for subsequent HIF-alpha degradation is thus a manifestation of the equilibrium between dioxygen in bulk solution and dioxygen bound to the PHD2.Fe.2OG.HIF-alpha substrate complex.	Oxygen	188-196	egl-9 family hypoxia inducible factor 1	Homo sapiens	210-214
31311728-0	2020	Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Insulin-Dependent Diabetes Mellitus Patients: A Pilot Study.	Oxygen	21-27	insulin	Homo sapiens	66-73
31994577-0	2020	An Fe-V@NiO heterostructure electrocatalyst towards the oxygen evolution reaction.	Oxygen	56-62	FEV transcription factor, ETS family member	Homo sapiens	3-7
32048999-3	2020	In this study, we show that hypoxia-inducible factor 1alpha (HIF1alpha), a central regulator of adaptation to limiting oxygen tension, is an unexpected but crucial regulator of innate immune-mediated nuclear reprogramming.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-59
32048999-3	2020	In this study, we show that hypoxia-inducible factor 1alpha (HIF1alpha), a central regulator of adaptation to limiting oxygen tension, is an unexpected but crucial regulator of innate immune-mediated nuclear reprogramming.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-70
31808470-4	2020	Taking advantage of the high catalytic efficiency of catalase when it meets hydrogen peroxide (H2O2), continuous oxygen can be generated due to the abnormally elevated level of H2O2 within the tumor, thus remarkably promoting tumor oxygenation.	Oxygen	113-119	catalase	Homo sapiens	53-61
31990036-5	2020	In this study, the transfection of human umbilical vein endothelial cells (HUVECs) with miR-101-3p mimic induced reactive oxygen species (ROS) production, EC dysfunction, and activated nuclear factor-kappaB (NF-kappaB), whereas transfection with miR-101-3p inhibitor alleviated these events.	Oxygen	122-128	nuclear factor kappa B subunit 1	Homo sapiens	208-217
31965792-5	2020	This cage contains potential Lewis acidic/basic active sites endowed by In3+ ions as Lewis acidic sites and the uncoordinated oxygen atoms of mu1-HCO2 moieties as Lewis basic sites and was explored as an effective heterogeneous catalyst in the cycloaddition of CO2 with epoxides and the Strecker reaction for amino nitriles.	Oxygen	126-132	glutathione S-transferase mu 1	Homo sapiens	142-145
31967459-2	2020	Inspired by the experimental development of a CoIII-peroxo complex (i.e., [CoIII(TBDAP)(O2)]+, TBDAP = N,N-ditert-butyl-2,11-diaza[3.3](2,6)-pyridinophane) that exhibits dioxygenase-like reactivity to activate nitriles, a density functional theory (DFT) mechanistic study has been carried out to understand how the peroxo ligand is broken to activate nitriles.	Oxygen	88-91	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	46-51
31967459-2	2020	Inspired by the experimental development of a CoIII-peroxo complex (i.e., [CoIII(TBDAP)(O2)]+, TBDAP = N,N-ditert-butyl-2,11-diaza[3.3](2,6)-pyridinophane) that exhibits dioxygenase-like reactivity to activate nitriles, a density functional theory (DFT) mechanistic study has been carried out to understand how the peroxo ligand is broken to activate nitriles.	Oxygen	88-91	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	75-80
31918224-0	2020	Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-alpha/BAFF signaling pathway.	Oxygen	9-15	tumor necrosis factor	Homo sapiens	144-153
31811910-8	2020	Taken together, our results suggest that FoxO3 could reverse 5-FU resistance in CRC via inhibiting the Nrf2/TR1 signaling pathway, and increasing the level of intracellular reactive oxygen species.	Oxygen	182-188	forkhead box O3	Homo sapiens	41-46
32116694-7	2020	Similarly, human retinal microvascular endothelial cells (HRMEC) subjected to hyperoxia (80% O2) showed a significant downregulation of miR-96 evaluated by qPCR.	Oxygen	93-95	microRNA 96	Homo sapiens	136-142
31590025-4	2020	Further investigations of Pb(II) adsorption on a selected UF microspheres showed fast kinetics and relatively high adsorption capacity (21.5 mg/g), which can be attributed to the mesoporous structure and abundance of oxygen surface functional groups of the microspheres.	Oxygen	217-223	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
31785945-6	2020	PCB 118 also induced excessive reactive oxygen species (ROS) in HUVECs.	Oxygen	40-46	pyruvate carboxylase	Homo sapiens	0-3
31712319-5	2020	SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD.	Oxygen	87-93	sirtuin 3	Homo sapiens	0-5
31683435-10	2020	Both in vivo and in vitro, CBNPs exposure significantly increased the expression of NLRP3 inflammasome, accompanied by the increased reactive oxygen species (ROS), decreased miR-96 and increased FOXO3a expressions dose -and time-dependently.	Oxygen	142-148	NLR family pyrin domain containing 3	Homo sapiens	84-89
32058297-4	2020	Generation of reactive oxygen species (ROS) and intracellular calcium mobilization can activate the NLRP3 inflammasome.	Oxygen	23-29	NLR family pyrin domain containing 3	Homo sapiens	100-105
31908078-5	2020	p53-induced mitochondrial elongation resulted in mitochondrial dysfunction and subsequent increases in intracellular reactive oxygen species (ROS) levels, an important mediator of cellular senescence.	Oxygen	126-132	tumor protein p53	Homo sapiens	0-3
31863907-0	2020	Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression.	Oxygen	20-26	signal transducer and activator of transcription 3	Homo sapiens	131-136
31981984-11	2020	In addition, the enhanced oxygen consumption rate is reduced in TSP-1-/- FD-VECs.	Oxygen	26-32	thrombospondin 1	Homo sapiens	64-69
31912559-7	2020	Attenuated obesity in MYOF KO mice on an HFD was also accompanied with increased oxygen consumption by an unidentified mechanism and with reduced adipose inflammation due to less inflammatory macrophages.	Oxygen	81-87	myoferlin	Mus musculus	22-26
31845380-6	2020	CD206+ and PD-L2+ cells were identified with high granularity and size, expressed arginase-1 and costimulatory molecules, had enhanced phagocytic activity, and produced reactive oxygen species (ROS).	Oxygen	178-184	programmed cell death 1 ligand 2	Sus scrofa	11-16
31879336-1	2020	BACKGROUND: Myeloperoxidase released after neutrophil and monocyte activation can generate reactive oxygen species, leading to host tissue damage.	Oxygen	100-106	myeloperoxidase	Homo sapiens	12-27
31013399-1	2020	Optimal function of immunoisolated islets requires adequate supply of oxygen to metabolically active insulin producing beta-cells.	Oxygen	70-76	insulin	Homo sapiens	101-108
31957305-0	2020	Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.	Oxygen	11-17	angiotensinogen	Homo sapiens	69-83
31957305-0	2020	Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.	Oxygen	11-17	mitogen-activated protein kinase 8	Homo sapiens	88-91
31901444-11	2020	Increased levels of superoxide anion (O2-) were found in the renal cortex of both WT and IL-10-deficient mice.	Oxygen	38-41	interleukin 10	Mus musculus	89-94
31875928-4	2020	In addition to DNA strand breaks, ATM and ATR also respond to oxidative DNA damage and reactive oxygen species (ROS), suggesting an unconventional function as regulators of intracellular redox status.	Oxygen	96-102	ATR serine/threonine kinase	Homo sapiens	42-45
31874167-9	2020	Moreover, at the cellular level, modulation of the CaSR regulates cytosolic Ca2+ levels, reactive oxygen species (ROS) generation and the mitogen-activated protein kinase (MAPK) signaling cascades as well as autophagy and the suppression of apoptosis, an effect predominantly triggered by heavy metals.	Oxygen	98-104	calcium sensing receptor	Homo sapiens	51-55
31916203-0	2020	Knockdown of IL-32 protects PC12 cells against oxygen-glucose deprivation/reoxygenation-induced injury via activation of Nrf2/NF-kappaB pathway.	Oxygen	47-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	121-125
31811499-5	2020	Using 172 mmol/L as sub-MIC value it was observed that yap1 deletion mutant was sensitive to lawsone independent the presence of oxygen.	Oxygen	129-135	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	55-59
31606879-11	2020	Oxygen cost improvements were larger in participants with higher VO2max (>= 52.3 ml kg-1 min-1) (0.39 [95% CI 0.06, 0.72], Z = 2.34, p = 0.02), and in programs greater or equal to 8 weeks (0.35 [95% CI 0.03, 0.67], Z = 2.13, p = 0.03).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
32007910-2	2020	The NQO1 bioactivatable agent beta-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species (ROS), which are actively scavenged in cells with NRF2/KEAP1 mutations.	Oxygen	129-135	NAD(P)H quinone dehydrogenase 1	Homo sapiens	4-8
32007910-2	2020	The NQO1 bioactivatable agent beta-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species (ROS), which are actively scavenged in cells with NRF2/KEAP1 mutations.	Oxygen	129-135	NFE2 like bZIP transcription factor 2	Homo sapiens	194-198
31912870-2	2020	The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1a via oxygen-dependent hydroxylation of proline residues and subsequent proteasomal degradation.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-46
31894856-5	2020	ERRalpha knockdown restored the inhibitory effects of lapatinib on the BT-474R cell viability and migration; in the meantime, ERRalpha knockdown rescued the production of reactive oxygen species (ROS)whereas decreased the ratio of glutathione (GSH)/ oxidized glutathione (GSSG)upon lapatinib treatment.	Oxygen	180-186	estrogen related receptor alpha	Homo sapiens	0-8
31894856-5	2020	ERRalpha knockdown restored the inhibitory effects of lapatinib on the BT-474R cell viability and migration; in the meantime, ERRalpha knockdown rescued the production of reactive oxygen species (ROS)whereas decreased the ratio of glutathione (GSH)/ oxidized glutathione (GSSG)upon lapatinib treatment.	Oxygen	180-186	estrogen related receptor alpha	Homo sapiens	126-134
31912870-2	2020	The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1a via oxygen-dependent hydroxylation of proline residues and subsequent proteasomal degradation.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-90
32012940-9	2020	The effect of oxygen and tumor necrosis factor alpha (TNFalpha) on MME protein in fpEC was investigated in vitro.	Oxygen	14-20	membrane metalloendopeptidase	Homo sapiens	67-70
32082261-0	2020	Hyperbaric Oxygen Ameliorates Insulin Sensitivity by Increasing GLUT4 Expression in Skeletal Muscle and Stimulating UCP1 in Brown Adipose Tissue in T2DM Mice.	Oxygen	11-17	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	64-69
32082261-3	2020	Therefore, we sought to determine whether hyperbaric oxygen would ameliorate insulin sensitivity by promoting glucose transporter type 4 (GLUT4) expression in muscle and by stimulating UCP1 in brown adipose tissue (BAT) in a streptozocin (STZ)-induced type 2 diabetes mellitus (T2DM) mouse model.	Oxygen	53-59	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	110-136
32082261-3	2020	Therefore, we sought to determine whether hyperbaric oxygen would ameliorate insulin sensitivity by promoting glucose transporter type 4 (GLUT4) expression in muscle and by stimulating UCP1 in brown adipose tissue (BAT) in a streptozocin (STZ)-induced type 2 diabetes mellitus (T2DM) mouse model.	Oxygen	53-59	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	138-143
32063866-9	2020	Estimated maximal oxygen uptake was ~52.5 ml kg-1 min-1 for females and 62.6 ml kg-1 min-1 for males (p &lt; 0.0001).	Oxygen	18-24	CD59 molecule (CD59 blood group)	Homo sapiens	50-55
31992279-7	2020	Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2).	Oxygen	59-65	C-reactive protein	Homo sapiens	117-135
31992279-7	2020	Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2).	Oxygen	59-65	C-reactive protein	Homo sapiens	137-140
32089648-4	2020	Here, we studied the control by CD154 of the proinflammatory cytokine interleukin- (IL-) 6 secretion in short-term oxygen (O2) deprivation conditions, using the HK-2 cell line as a kidney tubular epithelial cell (TEC) model.	Oxygen	115-121	CD40 ligand	Homo sapiens	32-37
32089648-8	2020	Therefore, CD154 is a potent early stimulus for IL-6 secretion by TECs in O2 deprivation conditions, a mechanism likely to take part in the deleterious inflammatory consequences of platelet activation in kidney tubular injury.	Oxygen	74-76	CD40 ligand	Homo sapiens	11-16
32089648-8	2020	Therefore, CD154 is a potent early stimulus for IL-6 secretion by TECs in O2 deprivation conditions, a mechanism likely to take part in the deleterious inflammatory consequences of platelet activation in kidney tubular injury.	Oxygen	74-76	interleukin 6	Homo sapiens	48-52
32019240-4	2020	Mounting evidence suggests that these defects increase oxidative stress susceptibility and reactive oxygen species production in FA, where the pathologic picture is worsened by a defective regulation of the expression and signaling pathway modulation of the transcription factor NF-E2 p45-related factor 2 (NRF2), one of the fundamental mediators of the cellular antioxidant response.	Oxygen	100-106	NFE2 like bZIP transcription factor 2	Homo sapiens	279-305
32019240-4	2020	Mounting evidence suggests that these defects increase oxidative stress susceptibility and reactive oxygen species production in FA, where the pathologic picture is worsened by a defective regulation of the expression and signaling pathway modulation of the transcription factor NF-E2 p45-related factor 2 (NRF2), one of the fundamental mediators of the cellular antioxidant response.	Oxygen	100-106	NFE2 like bZIP transcription factor 2	Homo sapiens	307-311
31687725-7	2020	In addition, reactive oxygen species triggered the activation of Nrf2 and the antioxidant system, including HO-1, r-GCS, and GSH-Px.	Oxygen	22-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
31687725-7	2020	In addition, reactive oxygen species triggered the activation of Nrf2 and the antioxidant system, including HO-1, r-GCS, and GSH-Px.	Oxygen	22-28	glutathione peroxidase 1	Rattus norvegicus	125-131
31733286-8	2020	Mechanistically, absence of PAR2 in MDSCs directly enhanced their immunosuppressive activity by promoting STAT3-mediated reactive oxygen species production.	Oxygen	130-136	signal transducer and activator of transcription 3	Homo sapiens	106-111
31897463-3	2020	CuA acts as an electron hub by transferring electrons from reduced cytochrome c to the catalytic site of the enzyme where dioxygen reduction takes place.	Oxygen	122-130	cytochrome c, somatic	Homo sapiens	67-79
32051875-7	2020	Using C2C12 myoblast cells, we have found that TBP increased mitochondrial mass and oxygen respiration, as well as the production of the IGF-1 hormone.	Oxygen	84-90	TATA box binding protein	Mus musculus	47-50
31979093-9	2020	In addition, MTDH knockdown increased reactive oxygen species (ROS) levels in MDA-MB-231/IR cells.	Oxygen	47-53	metadherin	Homo sapiens	13-17
31901818-5	2020	Besides, Cu-bound NMPs (Cu-NMPs) could serve as combined POD, superoxide dismutase (SOD), and CAT alternatives, which exhibited prominent reactive oxygen species (ROS) scavenging ability, revealing great potential in anti-inflammation.	Oxygen	147-153	superoxide dismutase 1	Homo sapiens	62-82
31901818-5	2020	Besides, Cu-bound NMPs (Cu-NMPs) could serve as combined POD, superoxide dismutase (SOD), and CAT alternatives, which exhibited prominent reactive oxygen species (ROS) scavenging ability, revealing great potential in anti-inflammation.	Oxygen	147-153	superoxide dismutase 1	Homo sapiens	84-87
31901818-5	2020	Besides, Cu-bound NMPs (Cu-NMPs) could serve as combined POD, superoxide dismutase (SOD), and CAT alternatives, which exhibited prominent reactive oxygen species (ROS) scavenging ability, revealing great potential in anti-inflammation.	Oxygen	147-153	catalase	Homo sapiens	94-97
31845986-5	2020	OXR1-overexpression alleviated the increases in reactive oxygen species (ROS) level and MN formation after irradiation.	Oxygen	57-63	oxidation resistance 1	Homo sapiens	0-4
31991669-6	2020	The effect was due to the decrease of intracellular reactive oxygen species, consequent inhibition of the Akt/IKKalpha-beta/NF-kB axis, and reduced transcriptional activation of the Pgp promoter by p65/p50 NF-kB.	Oxygen	61-67	AKT serine/threonine kinase 1	Homo sapiens	106-109
31991669-6	2020	The effect was due to the decrease of intracellular reactive oxygen species, consequent inhibition of the Akt/IKKalpha-beta/NF-kB axis, and reduced transcriptional activation of the Pgp promoter by p65/p50 NF-kB.	Oxygen	61-67	ATP binding cassette subfamily B member 1	Homo sapiens	182-185
31991669-6	2020	The effect was due to the decrease of intracellular reactive oxygen species, consequent inhibition of the Akt/IKKalpha-beta/NF-kB axis, and reduced transcriptional activation of the Pgp promoter by p65/p50 NF-kB.	Oxygen	61-67	nuclear factor kappa B subunit 1	Homo sapiens	202-205
31993073-5	2020	In atherosclerotic plaques, excessive generation of reactive oxygen species (ROS) activates the NLRP3 inflammasome.	Oxygen	61-67	NLR family pyrin domain containing 3	Homo sapiens	96-101
32039207-7	2019	In addition, TRADD was critical for the accumulation of reactive oxygen species (ROS), which contributed to RIPK1-independent necroptosis triggered by TNF.	Oxygen	65-71	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	108-113
32039207-7	2019	In addition, TRADD was critical for the accumulation of reactive oxygen species (ROS), which contributed to RIPK1-independent necroptosis triggered by TNF.	Oxygen	65-71	tumor necrosis factor	Mus musculus	151-154
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Oxygen	150-156	catalase	Homo sapiens	0-8
31948482-10	2020	Ang II infusion increased media to lumen ratio and caused fibrosis and reactive oxygen species production in the aorta of Cyp1b1+/+ mice.	Oxygen	80-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
32064022-0	2020	Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation.	Oxygen	49-55	ETS transcription factor ERG	Homo sapiens	73-77
31961852-7	2020	SUB signaling affects early increase of intracellular reactive oxygen species, stress gene induction as well as ectopic lignin and callose accumulation upon exogenous application of the cellulose biosynthesis inhibitor isoxaben.	Oxygen	63-69	Leucine-rich repeat protein kinase family protein	Arabidopsis thaliana	0-3
31988590-0	2020	Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway.	Oxygen	50-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	150-154
32055241-11	2020	Conclusion: We predict that miR-208 is involved in oxygen metabolism and regulation of cellular energy balance.	Oxygen	51-57	microRNA 208a	Homo sapiens	28-35
31948482-2	2020	This study was conducted to test the hypothesis that 6beta-OHT contributes to increased vascular reactivity, endothelial dysfunction, vascular hypertrophy, and reactive oxygen species production associated with Ang II-induced hypertension.	Oxygen	169-175	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	211-217
31963256-1	2020	Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility.	Oxygen	150-156	catalase	Homo sapiens	10-13
31963305-0	2020	JNK Pathway Mediates Low Oxygen Level Induced Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer Cells.	Oxygen	25-31	mitogen-activated protein kinase 8	Homo sapiens	0-3
31931869-7	2020	Assessment of global energy metabolism in real time demonstrated Abeta-mediated reduction in oxygen consumption affecting basal and maximal respiration and causing decreased ATP production.	Oxygen	93-99	amyloid beta precursor protein	Homo sapiens	65-70
31949174-4	2020	Maximal oxygen consumption ([Formula: see text]) in ml min-1 kg-1 was estimated.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	55-65
31849213-6	2020	Catalase (CAT) was encapsulated to catalyze the production of oxygen (O2) from H2O2.	Oxygen	62-68	catalase	Mus musculus	0-8
31849213-6	2020	Catalase (CAT) was encapsulated to catalyze the production of oxygen (O2) from H2O2.	Oxygen	62-68	catalase	Mus musculus	10-13
31761381-5	2020	10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis.	Oxygen	353-359	tumor protein p53	Homo sapiens	60-63
31761381-5	2020	10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis.	Oxygen	353-359	tumor protein p53	Homo sapiens	80-83
31761381-5	2020	10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis.	Oxygen	353-359	tumor protein p53	Homo sapiens	80-83
31805339-6	2020	Mitochondria isolated from the affected region of the spinal cord of nano-SOD/CAT treated animals demonstrated significantly reduced mitochondrial reactive oxygen species (ROS) activities, increased mitochondrial membrane potential, reduced calcium levels, and also higher adenosine triphosphate (ATP) production capacity than those isolated from the spinal cords of untreated control or SOD/CAT solution treated animals.	Oxygen	156-162	catalase	Rattus norvegicus	78-81
31941010-11	2020	Furthermore, the mechanism study found that PPVI could activate the NF-kappaB signaling pathway via increasing reactive oxygen species (ROS) levels in A549 and H1299 cells, and N-acetyl-L-cysteine (NAC), a scavenger of ROS, remarkably inhibited the cell death, and the activation of NF-kappaB and the NLRP3 inflammasome in PPVI-treated A549 and H1299 cells.	Oxygen	120-126	nuclear factor kappa B subunit 1	Homo sapiens	68-77
31820975-0	2020	Development of novel oxotriazinoindole inhibitors of aldose reductase: isosteric sulfur/oxygen replacement in the thioxotriazinoindole cemtirestat markedly improved inhibition selectivity.	Oxygen	88-94	aldo-keto reductase family 1 member B	Homo sapiens	53-69
31951520-1	2020	Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1alpha, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD).	Oxygen	66-72	erythropoietin	Homo sapiens	0-14
31951520-1	2020	Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1alpha, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD).	Oxygen	66-72	erythropoietin	Homo sapiens	16-19
31951520-1	2020	Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1alpha, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD).	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
31820975-2	2020	We proceeded with optimization of the thioxotriazinoindole scaffold of the novel aldose reductase inhibitor cemtirestat by replacement of sulfur with oxygen.	Oxygen	150-156	aldo-keto reductase family 1 member B	Homo sapiens	81-97
31820975-4	2020	More electronegative and less bulky oxygen of OTIs compared to the sulfur of the original thioxotriazinoindole congeners was found to form stronger H-bond with Leu300 of AR and to render larger rotational flexibility of the carboxymethyl pharmacophore.	Oxygen	36-42	aldo-keto reductase family 1 member B	Homo sapiens	170-172
31618435-2	2020	Hypoxia-inducible transcription factor prolyl hydroxylase-containing enzymes (PHD1, PHD2, and PHD3) are molecular oxygen sensors that control adaptive gene expression through hypoxia-inducible factor (HIF).	Oxygen	114-120	egl-9 family hypoxia inducible factor 1	Homo sapiens	84-88
31936545-4	2020	Here we present an extension of the chemical module of the Monte Carlo particle track structure code TRAX, taking into account the presence of dissolved molecular oxygen in the target material.	Oxygen	163-169	translin associated factor X	Homo sapiens	101-105
31936545-13	2020	Here we present an extension of the chemical module of the Monte Carlo particle track structure code TRAX, taking into account the presence of dissolved molecular oxygen in the target material.	Oxygen	163-169	translin associated factor X	Homo sapiens	101-105
31721616-0	2020	Reactive Oxygen Species-Dependent Regulation of PDK4 in White Adipose Tissue.	Oxygen	9-15	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	48-52
31793717-2	2020	Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy.	Oxygen	113-119	transferrin	Homo sapiens	30-41
31802447-2	2020	Metallic nanomaterials are capable of mimicking all the three major antioxidant enzymes such as catalase (CAT), peroxidase and oxidase, to control the level of reactive oxygen species (ROS) inside the cell as an alternative strategy over conventional one which has biological toxicity and have several adverse effects, if accumulation takes places during the treatment.	Oxygen	169-175	catalase	Homo sapiens	96-104
31802447-2	2020	Metallic nanomaterials are capable of mimicking all the three major antioxidant enzymes such as catalase (CAT), peroxidase and oxidase, to control the level of reactive oxygen species (ROS) inside the cell as an alternative strategy over conventional one which has biological toxicity and have several adverse effects, if accumulation takes places during the treatment.	Oxygen	169-175	catalase	Homo sapiens	106-109
31860288-5	2020	Reactions with four equimolar amounts of AgL (L = CH3COO- or NO3-) in water-acetone gave doubly oxido- and bidentate oxygen donor ligand-bridged diruthenium complexes of Ru(III)-Ru(IV), [{RuIII,IV(ebpma)}2(mu-O)2(mu-L)]2+ ([3L]2+; L = O2CCH3; [3CH3COO]2+, L = O2NO; [3NO3]2+).	Oxygen	117-123	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	41-44
33350989-2	2020	Sustained advanced glycation end products (AGEs) receptor (RAGE) activation triggers the production of reactive oxygen species and inflammatory response, leading to neuronal dysfunction and neurodegenerative disorders.	Oxygen	112-118	advanced glycosylation end product-specific receptor	Mus musculus	10-57
33350989-2	2020	Sustained advanced glycation end products (AGEs) receptor (RAGE) activation triggers the production of reactive oxygen species and inflammatory response, leading to neuronal dysfunction and neurodegenerative disorders.	Oxygen	112-118	advanced glycosylation end product-specific receptor	Mus musculus	59-63
31619063-7	2020	AIP1B, which lacks the N-terminal pleckstrin homology domain of AIP1A, localized to the mitochondria and augmented TNF (tumor necrosis factor)-induced mitochondrial reactive oxygen species generation and EC activation.	Oxygen	174-180	DAB2 interacting protein	Homo sapiens	0-5
31906399-6	2020	Lnv-adipo-HO-1-transfected mice on a HFD display increased cellular respiration, increased oxygen consumption, increased mitochondrial function, and decreased adipocyte size.	Oxygen	91-97	heme oxygenase 1	Mus musculus	10-14
31906396-0	2020	Melatonin Prevents Transforming Growth Factor-beta1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms.	Oxygen	160-166	transforming growth factor beta 1	Homo sapiens	19-51
31619063-7	2020	AIP1B, which lacks the N-terminal pleckstrin homology domain of AIP1A, localized to the mitochondria and augmented TNF (tumor necrosis factor)-induced mitochondrial reactive oxygen species generation and EC activation.	Oxygen	174-180	tumor necrosis factor	Homo sapiens	115-118
31619063-7	2020	AIP1B, which lacks the N-terminal pleckstrin homology domain of AIP1A, localized to the mitochondria and augmented TNF (tumor necrosis factor)-induced mitochondrial reactive oxygen species generation and EC activation.	Oxygen	174-180	tumor necrosis factor	Homo sapiens	120-141
31619063-8	2020	AIP1B-ECTG (EC-specific AIP1B transgenic) mice exhibited augmented reactive oxygen species production, EC activation, and neointima formation in vascular remodeling models.	Oxygen	76-82	DAB2 interacting protein	Homo sapiens	0-5
31619063-8	2020	AIP1B-ECTG (EC-specific AIP1B transgenic) mice exhibited augmented reactive oxygen species production, EC activation, and neointima formation in vascular remodeling models.	Oxygen	76-82	DAB2 interacting protein	Homo sapiens	24-29
31606133-11	2020	Moreover, ET-1 stimulated formation of reactive oxygen species (ROS) in THP-1-derived macrophages via an arginase-dependent mechanism.	Oxygen	48-54	endothelin 1	Homo sapiens	10-14
31490096-0	2020	Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.	Oxygen	21-27	NLR family pyrin domain containing 3	Homo sapiens	141-146
31707348-4	2020	In the study, our results showed that BRD4 expression was up-regulated in human and mouse hypertrophied hearts, and importantly these effects were modulated by reactive oxygen species (ROS) generation.	Oxygen	169-175	bromodomain containing 4	Homo sapiens	38-42
31664507-5	2020	Furthermore, the hydrogen bonding between the interfacial oxygen atoms of CeO2 and lysine residues of the cytochrome c in bacteria yields excellent extracellular electron transfer efficiency.	Oxygen	58-64	cytochrome c, somatic	Homo sapiens	106-118
32116239-0	2020	Serum levels of nitric oxide and endothelin-1 in vasculopathy managed with hyperbaric oxygen therapy.	Oxygen	86-92	endothelin 1	Homo sapiens	33-45
31731193-12	2020	In addition, VIP inhibited the generation of reactive oxygen species in macrophages by decreasing NOX1 and NOX2 expression.	Oxygen	54-60	vasoactive intestinal polypeptide	Mus musculus	13-16
31884142-8	2020	The presence of the amino protonated group attached at the benzothiazole moiety was essential for the antiproliferative and antioxidant activity observed, exerted through a change in the levels of the reactive oxygen species-modulated HIF-1 protein.	Oxygen	210-216	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-240
31796664-2	2020	Reactive oxygen species released from mitochondria can activate Nrf2, and the Nrf2/Keap1 pathway affects glycolysis, oxidative phosphorylation, mitochondrial biogenesis and mitophagy.	Oxygen	9-15	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
31796664-2	2020	Reactive oxygen species released from mitochondria can activate Nrf2, and the Nrf2/Keap1 pathway affects glycolysis, oxidative phosphorylation, mitochondrial biogenesis and mitophagy.	Oxygen	9-15	kelch like ECH associated protein 1	Homo sapiens	83-88
31790952-1	2020	Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner.	Oxygen	134-140	tumor necrosis factor	Homo sapiens	0-27
31790952-1	2020	Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner.	Oxygen	134-140	tumor necrosis factor	Homo sapiens	29-32
33216018-10	2020	RESULTS: After exposure to hyperbaric oxygen, cell culturess showed a significant increase in the expression of VEGF after 3 and 5 days.	Oxygen	38-44	vascular endothelial growth factor A	Homo sapiens	112-116
32691710-3	2020	Different signaling pathways such as PI3K-AKt-mTOR, MAPK, HIF-1alpha, etc active or inactive by the amount and type of energy source or oxygen levels that determine the fate of T cells in a cancerous environment.	Oxygen	136-142	AKT serine/threonine kinase 1	Homo sapiens	42-45
31880261-0	2020	Propofol pretreatment prevents oxygen-glucose deprivation/reoxygenation(OGD/R)-induced inflammation through nuclear transcription factor kappaB (NF-kappaB) pathway in neuroblastoma cells.	Oxygen	31-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-143
31880261-0	2020	Propofol pretreatment prevents oxygen-glucose deprivation/reoxygenation(OGD/R)-induced inflammation through nuclear transcription factor kappaB (NF-kappaB) pathway in neuroblastoma cells.	Oxygen	31-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
31889485-3	2020	These enzymes inhibit hypoxic response by inducing the oxygen-dependent degradation of hypoxia-inducible factor 1alpha, the master regulator of the transcriptional hypoxic response.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-118
31624141-9	2020	In vitro exposure of human renal proximal tubular epithelial cells to C5a led to altered mitochondrial respiratory function and reactive oxygen species generation.	Oxygen	137-143	complement C5a receptor 1	Homo sapiens	70-73
31804169-5	2020	It has been observed that nickel exposure induces the generation of reactive oxygen species which leads to the increased expression of p53, NF-kbeta, AP-1, and MAPK.	Oxygen	77-83	tumor protein p53	Homo sapiens	135-138
32738735-7	2020	Cardiac differentiation in 5% instead of 20% oxygen resulted in reduced development of spontaneously beating cardiomyocytes and lower expression of cardiac markers Nkx2.5, Myh6 and MF20 (myosin), regardless whether ESC had been cultured in 5% or 20% oxygen tension.	Oxygen	45-51	NK2 homeobox 5	Homo sapiens	164-170
32738735-7	2020	Cardiac differentiation in 5% instead of 20% oxygen resulted in reduced development of spontaneously beating cardiomyocytes and lower expression of cardiac markers Nkx2.5, Myh6 and MF20 (myosin), regardless whether ESC had been cultured in 5% or 20% oxygen tension.	Oxygen	45-51	myosin heavy chain 6	Homo sapiens	172-176
31839365-2	2020	Mouse embryonic fibroblasts (MEFs) lacking Klf4 exhibit genomic instability, increased reactive oxygen species (ROS), and decreased autophagy.	Oxygen	96-102	Kruppel-like factor 4 (gut)	Mus musculus	43-47
32151172-2	2020	Decreased p50 suggested the presence of a high oxygen affinity hemoglobin (Hb) variant.	Oxygen	47-53	nuclear factor kappa B subunit 1	Homo sapiens	10-13
31654708-8	2020	Furthermore, SA that bound to Toll-Like Receptor 4 (TLR4) was able to reduce endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) generation in response to LPS stimulation.	Oxygen	124-130	toll-like receptor 4	Mus musculus	30-50
31654708-8	2020	Furthermore, SA that bound to Toll-Like Receptor 4 (TLR4) was able to reduce endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) generation in response to LPS stimulation.	Oxygen	124-130	toll-like receptor 4	Mus musculus	52-56
30895638-0	2020	The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.	Oxygen	33-39	hypocretin neuropeptide precursor	Rattus norvegicus	48-54
31804891-7	2020	MVM erythropoietin receptor abundance, determined by immunoblot, was greater in HA than in LA placentas, consistent with lower placental oxygen levels at HA.	Oxygen	137-143	erythropoietin	Homo sapiens	4-18
31856355-11	2020	The transfection of a dominant negative transmembrane deletion construct of BNIP3 (BNIP3DeltaTM) and treatment of a reactive oxygen species (ROS) inhibitor suppressed chemo drug-induced cell death.	Oxygen	125-131	BCL2 interacting protein 3	Homo sapiens	76-81
31856355-11	2020	The transfection of a dominant negative transmembrane deletion construct of BNIP3 (BNIP3DeltaTM) and treatment of a reactive oxygen species (ROS) inhibitor suppressed chemo drug-induced cell death.	Oxygen	125-131	BCL2 interacting protein 3	Homo sapiens	83-95
31724066-3	2020	The superoxide dismutase (SOD), an antioxidant enzyme, plays an essential pathogenic role in the inflammatory diseases by not only catalyzing the conversion of the superoxide to hydrogen peroxide and oxygen but also affecting immune responses.	Oxygen	200-206	superoxide dismutase 1	Homo sapiens	4-24
31724066-3	2020	The superoxide dismutase (SOD), an antioxidant enzyme, plays an essential pathogenic role in the inflammatory diseases by not only catalyzing the conversion of the superoxide to hydrogen peroxide and oxygen but also affecting immune responses.	Oxygen	200-206	superoxide dismutase 1	Homo sapiens	26-29
31778952-3	2020	Here we show that an increase of oxidative stress (ROS and singlet oxygen), generated by photoactivated TMPyP4, results in the upregulation of KRAS and Nrf2, the major regulator of the redox homeostasis.	Oxygen	67-73	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
31782270-10	2020	Mechanical investigations revealed that TAM enabled potent reactive oxygen species (ROS) production by reduced nuclear factor Nrf2 expression and its target genes, leading to the activation of AMPK, which subsequently induced impaired glycolysis and survival advantages.	Oxygen	68-74	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
31646664-7	2020	This study shows that a 30-min thermal treatment at 120 C generates antioxidative MRPs in the rutin-Lys, rutin-His, rutin-Ile and rutin-Glu model systems, which can directly inhibit reactive oxygen species generation and enhance SOD and CAT activities while activating the Nrf2-dependent pathway and upregulating the expression of phase II detoxifying antioxidant genes.	Oxygen	191-197	NFE2 like bZIP transcription factor 2	Homo sapiens	273-277
31663146-11	2020	It has been proved that wheat bran has a good blood pressure lowering and antioxidation and other biological activities, and the <1 kDa fraction showing high oxygen radical absorbance capacity level also has better in vitro ACE inhibition and renin-inhibitory activity.	Oxygen	158-164	angiotensin I converting enzyme	Rattus norvegicus	224-227
31721213-1	2020	KEY POINTS: -We determined if bed rest increased mitochondrial derived reactive oxygen species and cellular redox stress, contributing to the induction insulin resistance -Bed rest decreased maximal and submaximal ADP-stimulated mitochondrial respiration -Bed rest did not alter mitochondrial H2 O2 emission in the presence of ADP concentrations indicative of resting muscle, the ratio of H2 O2 emission to JO2 consumption, or markers of oxidative stress -The present data strongly suggests that mitochondrial H2 O2 does not contribute to bed rest-induced insulin resistance ABSTRACT: Mitochondrial H2 O2 has been causally linked to diet-induced insulin resistance, however it remains unclear if muscle disuse similarly increases mitochondrial H2 O2 .	Oxygen	80-86	insulin	Homo sapiens	152-159
31833075-2	2020	Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2 ), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2 .	Oxygen	20-26	prostaglandin D2 synthase	Homo sapiens	33-37
32808228-4	2020	Combining fluorescent dyes with cell surface antibodies, we demonstrate how to analyze mitochondrial density, membrane potential, and reactive oxygen species production in CD4 and CD8 T cells from cryopreserved clinical samples.	Oxygen	143-149	CD4 molecule	Homo sapiens	172-175
32943144-5	2020	Depending on the catalase expression level, microcolonies of library bacteria with active protease variants contained in polymeric droplets generate an oxygen bubble, which causes a density shift in the droplet and enables it to float.	Oxygen	152-158	catalase	Homo sapiens	17-25
31801996-5	2020	We find that the RGF1-receptor pathway controls the distribution of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root.	Oxygen	77-83	root meristem growth factor 1	Arabidopsis thaliana	17-21
31392515-7	2020	In vitro studies in human retinal cells showed that alamandine attenuated the Ang II and LPS-induced increases in inflammatory cytokine gene expression, NF-kappaB activation, Ang II and hydrogen peroxide-induced production of reactive oxygen species, comparable to that mediated by Ang-(1-7).	Oxygen	235-241	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	78-84
31819254-5	2020	This triggers Lyn/Syk-dependent calcium entry and the production of reactive oxygen species, leading to activation of caspase-8.	Oxygen	77-83	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
31883860-7	2020	HIF-1alpha is a key mediator of chondrocyte response to fluctuations in oxygen availability during cartilage development or damage, and its expression was unregulated by ICA treatment.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
31853067-6	2020	In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species.	Oxygen	116-122	modifier of curly tail 1	Mus musculus	27-31
31358683-10	2020	Therefore, our results identify a role for AGO1 and AGO4 RNA-silencing pathways in low-oxygen signaling in Arabidopsis.	Oxygen	87-93	Stabilizer of iron transporter SufD / Polynucleotidyl transferase	Arabidopsis thaliana	43-47
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Oxygen	293-299	AKT serine/threonine kinase 1	Homo sapiens	14-17
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Oxygen	293-299	BCL2 like 1	Homo sapiens	186-192
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Oxygen	293-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31790899-8	2020	HIF-1 activation could be partly attributed to an increase in radical oxygen species and a decrease in superoxide dismutase activity.	Oxygen	70-76	Hypoxia-inducible factor 1	Caenorhabditis elegans	0-5
32018260-6	2020	RG suppressed Abeta-induced increases in intracellular and mitochondrial reactive oxygen species (ROS) levels and mitochondrial dysfunction (determined by low mitochondrial membrane potential and oxygen consumption rate) in a dose-dependent manner.	Oxygen	82-88	amyloid beta precursor protein	Homo sapiens	14-19
32018260-6	2020	RG suppressed Abeta-induced increases in intracellular and mitochondrial reactive oxygen species (ROS) levels and mitochondrial dysfunction (determined by low mitochondrial membrane potential and oxygen consumption rate) in a dose-dependent manner.	Oxygen	196-202	amyloid beta precursor protein	Homo sapiens	14-19
32971113-0	2020	Age-related change in peak oxygen uptake and change of cardiovascular risk factors.	Oxygen	27-33	renin binding protein	Homo sapiens	0-3
31897199-2	2020	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a crucial transcription factor regulating oxygen homeostasis that is involved in tumor cell metastasis.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
31897199-2	2020	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a crucial transcription factor regulating oxygen homeostasis that is involved in tumor cell metastasis.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
31707353-8	2020	Impaired inflammasome activation in G6PD-kd THP-1 cells was mediated by a decrease in the production of reactive oxygen species (ROS) by NOX signaling, while treatment with hydrogen peroxide (H2O2) enhanced inflammasome activation in G6PD-kd THP-1 cells.	Oxygen	113-119	GLI family zinc finger 2	Homo sapiens	44-49
31606550-3	2020	An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells.	Oxygen	221-227	fms related receptor tyrosine kinase 3	Homo sapiens	37-41
31606550-3	2020	An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells.	Oxygen	221-227	fms related receptor tyrosine kinase 3	Homo sapiens	141-145
31606550-3	2020	An underlying rationale was that the FLT3 gene is frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants of FLT3 with "internal tandem duplications (FLT3ITD)" drive production of reactive oxygen in leukemic cells.	Oxygen	221-227	fms related receptor tyrosine kinase 3	Homo sapiens	182-189
31639651-0	2020	Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway.	Oxygen	44-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	134-139
31639651-0	2020	Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway.	Oxygen	44-50	heme oxygenase 1	Mus musculus	140-144
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	heat shock protein 5	Mus musculus	150-182
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	heat shock protein 5	Mus musculus	184-189
31539803-0	2020	The NOTCH1-dependent HIF1alpha/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha a	Danio rerio	21-30
31765888-6	2020	In addition, Alkbh8def MEFs undergo a metabolic shift that is highlighted by a striking increase in the level of uncoupling protein 2 (UCP2) which enhances oxygen consumption and promotes a reliance on glycolytic metabolism.	Oxygen	156-162	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	113-133
31765888-6	2020	In addition, Alkbh8def MEFs undergo a metabolic shift that is highlighted by a striking increase in the level of uncoupling protein 2 (UCP2) which enhances oxygen consumption and promotes a reliance on glycolytic metabolism.	Oxygen	156-162	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	135-139
31539803-0	2020	The NOTCH1-dependent HIF1alpha/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation.	Oxygen	45-51	vestigial-like family member 4b	Danio rerio	31-36
31539803-3	2020	In this study, after detecting the upregulation of vgll4b in response to oxygen levels, we generated vgll4b mutant zebrafish using CRISPR/Cas9, and verified the resulting impaired heme and dysfunctional erythroid terminal differentiation phenotype.	Oxygen	73-79	vestigial-like family member 4b	Danio rerio	51-57
31539803-8	2020	Our study also indicates that VGLL4 is a key player in the mediation of NOTCH1-dependent HIF1alpha-regulated erythropoiesis and can be sensitively regulated by oxygen concentrations.	Oxygen	160-166	vestigial-like family member 4b	Danio rerio	30-35
31539803-8	2020	Our study also indicates that VGLL4 is a key player in the mediation of NOTCH1-dependent HIF1alpha-regulated erythropoiesis and can be sensitively regulated by oxygen concentrations.	Oxygen	160-166	hypoxia inducible factor 1 subunit alpha a	Danio rerio	89-98
31539803-9	2020	On the other hand, VGLL4 is a pivotal regulator of heme biosynthesis and erythroid terminal differentiation, which collectively improve oxygen metabolism.	Oxygen	136-142	vestigial-like family member 4b	Danio rerio	19-24
31912702-6	2019	Oxygen-glucose deprivation up-regulated the expression of regulator of reprogramming, and regulator of reprogramming promoted ASK-1/STRAP/14-3-3 complex formation to inhibit the activation of TNF-alpha/ASK-1-mediated apoptosis of human brain microvascular endothelial cells, while small interfering ribonucleic acid (RNA) targeting regulator of reprogramming amplified these effects.	Oxygen	0-6	tumor necrosis factor	Homo sapiens	192-201
31799810-6	2020	Substructural damage and obvious mitochondria membrane potential depolarization are caused subsequently with the combined action of numerously reactive oxygen species production, ultimately initiating the apoptotic process through the translocation of cytochrome c to the cytoplasm and activating apoptotic markers including caspase-9 and -3.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	252-264
31911948-2	2020	Genetic deletion of Epac1 ameliorated pathological angiogenesis in mouse models of oxygen-induced retinopathy (OIR) and carotid artery ligation.	Oxygen	83-89	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	20-25
31760267-2	2020	We previously identified anti-TNFalpha-induced apoptosis (ATIA, also known as vasorin) as an antiapoptotic factor that suppresses reactive oxygen species (ROS) production.	Oxygen	139-145	tumor necrosis factor	Homo sapiens	30-38
31878222-3	2019	Robust evidence suggests that the major mechanism driving impaired beta-cell function and insulin signalling is through the action of intracellular reactive oxygen species (ROS)-induced stress.	Oxygen	157-163	insulin	Homo sapiens	90-97
31890203-1	2019	Background: Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-50
31890203-4	2019	Transcriptome studies were performed to identify gene expression changes induced by hypoxia or by overexpression of oxygen-insensitive HIF1 and HIF2 mutants.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-139
31878222-5	2019	Reactive oxygen species can disrupt intracellular signalling pathways, thereby dysregulating the expression of genes associated with insulin secretion and signalling.	Oxygen	9-15	insulin	Homo sapiens	133-140
31878239-1	2019	DJ-1 was recently reported to be involved in the cardioprotection of hypoxic preconditioning (HPC) against hypoxia/reoxygenation (H/R)-induced oxidative stress damage, by preserving mitochondrial complex I activity and, subsequently, inhibiting mitochondrial reactive oxygen species (ROS) generation.	Oxygen	117-123	Parkinsonism associated deglycase	Rattus norvegicus	0-4
31878047-9	2019	Reactive oxygen species (ROS) appeared to play a key role in ASC stimulation as the inhibition of ROS generation and NOX4 knockout attenuated ASC stimulation and THPO upregulation by HB-EGF.	Oxygen	9-15	thrombopoietin	Homo sapiens	162-166
31903165-6	2019	Compared to wild-type cells, KEAP1-disrupted cells showed lower basal and sorafenib-induced reactive oxygen species (ROS) levels and were more resistant to oxidative stress-induced cell death.	Oxygen	101-107	kelch like ECH associated protein 1	Homo sapiens	29-34
31870428-2	2019	Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1beta and IL-18, leading to the aggravation of the downstream inflammatory response.	Oxygen	9-15	NLR family pyrin domain containing 3	Homo sapiens	94-99
31870428-2	2019	Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1beta and IL-18, leading to the aggravation of the downstream inflammatory response.	Oxygen	9-15	interleukin 1 beta	Homo sapiens	164-172
31862915-5	2019	We report converse syncytin-1 and SUPYN transcriptional and translational responses to surrounding oxygen concentrations that suggest both are important in the effects of hypoxia and hyperoxia on placental syncytialization.	Oxygen	99-105	endogenous retrovirus group W member 1, envelope	Homo sapiens	19-29
31862915-5	2019	We report converse syncytin-1 and SUPYN transcriptional and translational responses to surrounding oxygen concentrations that suggest both are important in the effects of hypoxia and hyperoxia on placental syncytialization.	Oxygen	99-105	endogenous retrovirus group 48 member 1	Homo sapiens	34-39
31920721-9	2019	In particular, higher production of reactive oxygen species deriving from a variety of enzymatic sources, including uncoupled endothelial nitric oxide synthase and the electron transport chain, causes DNA damage and activates the NAD+-consuming enzymes polyADP-ribose polymerase 1 (PARP1).	Oxygen	45-51	nitric oxide synthase 3	Homo sapiens	126-159
31920721-9	2019	In particular, higher production of reactive oxygen species deriving from a variety of enzymatic sources, including uncoupled endothelial nitric oxide synthase and the electron transport chain, causes DNA damage and activates the NAD+-consuming enzymes polyADP-ribose polymerase 1 (PARP1).	Oxygen	45-51	poly(ADP-ribose) polymerase 1	Homo sapiens	253-280
31920721-9	2019	In particular, higher production of reactive oxygen species deriving from a variety of enzymatic sources, including uncoupled endothelial nitric oxide synthase and the electron transport chain, causes DNA damage and activates the NAD+-consuming enzymes polyADP-ribose polymerase 1 (PARP1).	Oxygen	45-51	poly(ADP-ribose) polymerase 1	Homo sapiens	282-287
31863782-3	2019	Here, we show that AgRP increases ad libitum feeding and operant responding for food in mice, decreases oxygen consumption, and lowers body temperature and activity, indicating lower energy expenditure.	Oxygen	104-110	agouti related neuropeptide	Mus musculus	19-23
31387048-6	2019	Meanwhile, the 80% oxygen treatment could increase the activities of phenylalanine ammonia lyase (PAL) and peroxidase (POD), and the total phenolic content.	Oxygen	19-25	suberization-associated anionic peroxidase	Solanum tuberosum	107-117
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	Oxygen	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31387048-6	2019	Meanwhile, the 80% oxygen treatment could increase the activities of phenylalanine ammonia lyase (PAL) and peroxidase (POD), and the total phenolic content.	Oxygen	19-25	suberization-associated anionic peroxidase	Solanum tuberosum	119-122
31938458-6	2020	These small molecules perturbed antiapoptotic (Bcl-2/Bcl-xl) and pro-apoptotic (Bax) proteins to produce reactive oxygen species (ROS).	Oxygen	114-120	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
31614143-4	2019	Here the effects of reactive oxygen species on the transactivation of the EGFR and HER2 were investigated.	Oxygen	29-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
31614143-7	2019	Neurotensin addition to NCI-H838 cells increased significantly reactive oxygen species which was inhibited by SR48692, Tiron (superoxide scavenger) and diphenylene iodonium (DPI inhibits the ability of NADPH oxidase and dual oxidase enzymes to produce reactive oxygen species).	Oxygen	72-78	neurotensin	Homo sapiens	0-11
31614143-7	2019	Neurotensin addition to NCI-H838 cells increased significantly reactive oxygen species which was inhibited by SR48692, Tiron (superoxide scavenger) and diphenylene iodonium (DPI inhibits the ability of NADPH oxidase and dual oxidase enzymes to produce reactive oxygen species).	Oxygen	261-267	neurotensin	Homo sapiens	0-11
31614143-11	2019	The results indicate that neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	114-120	epidermal growth factor receptor	Homo sapiens	86-90
31614143-11	2019	The results indicate that neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	114-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
31920538-1	2019	Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation.	Oxygen	80-86	cytoglobin	Rattus norvegicus	0-10
31920538-1	2019	Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation.	Oxygen	80-86	cytoglobin	Rattus norvegicus	12-16
31614143-0	2019	Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	82-88	neurotensin	Homo sapiens	0-11
31614143-0	2019	Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	82-88	epidermal growth factor receptor	Homo sapiens	54-58
31614143-0	2019	Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	82-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
31614143-4	2019	Here the effects of reactive oxygen species on the transactivation of the EGFR and HER2 were investigated.	Oxygen	29-35	epidermal growth factor receptor	Homo sapiens	74-78
31470321-4	2019	50 nM C10-HSL showed a negligible effect on the granulation process while 5000 nM C10-HSL achieved the best performance with the highest chemical oxygen demand (COD) removal, largest granule size and best extracellular polymeric substance production.	Oxygen	146-152	homeobox C10	Homo sapiens	82-89
31748766-1	2019	Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen storage, oxygen activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.	Oxygen	67-73	cytochrome c, somatic	Homo sapiens	216-228
33423492-4	2019	Monolayer cultures under low oxygen conditions exhibited increased expression of hypoxia-related genes such as VEGF, CAIX, and GLUT1.	Oxygen	29-35	vascular endothelial growth factor A	Homo sapiens	111-115
31748766-1	2019	Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen storage, oxygen activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.	Oxygen	84-90	cytochrome c, somatic	Homo sapiens	216-228
31748766-1	2019	Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen storage, oxygen activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.	Oxygen	84-90	cytochrome c, somatic	Homo sapiens	216-228
31809527-3	2019	Here, we have uncovered that Snf5, a subunit of SWI/SNF chromatin remodeling complex, is a major transcriptional regulator that links oxygen status to the metabolic capacity of C. albicans.	Oxygen	134-140	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Mus musculus	29-33
31808750-6	2019	Sirt3 knockdown reduced the oxygen consumption and ATP production in primary neurons with the human ApoE3, while Sirt3 overexpression protected these damages in ApoE4 neurons.Our findings suggest that ApoE4 suppresses mitochondrial function via the PGC-1alpha- Sirt3 pathway.	Oxygen	28-34	sirtuin 3	Homo sapiens	0-5
31808750-6	2019	Sirt3 knockdown reduced the oxygen consumption and ATP production in primary neurons with the human ApoE3, while Sirt3 overexpression protected these damages in ApoE4 neurons.Our findings suggest that ApoE4 suppresses mitochondrial function via the PGC-1alpha- Sirt3 pathway.	Oxygen	28-34	apolipoprotein E	Homo sapiens	201-206
31804464-4	2019	In this study, we explored the intriguing ability of LRRC8/VRAC to transport glutathione (GSH), the major cellular reactive oxygen species (ROS) scavenger, and its involvement in epithelial-to-mesenchymal transition (EMT), a cellular process in which cellular oxidative status is a crucial step.	Oxygen	124-130	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	53-58
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	angiotensinogen	Rattus norvegicus	42-56
31920915-0	2019	SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury.	Oxygen	63-69	sirtuin 1	Rattus norvegicus	0-5
31920915-3	2019	We investigated the effect of SIRT1 on oxygen and glucose deprivation/reperfusion (OGD/R) cell injury.	Oxygen	39-45	sirtuin 1	Rattus norvegicus	30-35
31817166-4	2019	Since the rise of oxygen-based metabolism and antioxidant defense systems are evolutionary coupled, SOD is an interesting protein with a deep evolutionary history.	Oxygen	18-24	superoxide dismutase 1	Homo sapiens	100-103
31844418-0	2019	Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.	Oxygen	39-45	inhibitor of growth family member 5	Homo sapiens	99-103
31804581-5	2019	In response to Pep-13 treatment, the formation of reactive oxygen species and MAP kinase activation, observed in wild type plants, is highly reduced in StSERK3A/B-RNAi plants, suggesting that StSERK3A/B are required for perception of Pep-13 in potato.	Oxygen	59-65	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like	Solanum tuberosum	152-162
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	angiotensinogen	Rattus norvegicus	58-64
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	93-98
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	SMAD family member 3	Rattus norvegicus	259-267
31871542-0	2019	NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells.	Oxygen	24-30	formyl peptide receptor 1	Homo sapiens	48-73
31732667-9	2019	We further demonstrate that macropinocytosis depends on MKK4 activated by elevated reactive oxygen species.	Oxygen	92-98	mitogen-activated protein kinase kinase 4	Homo sapiens	56-60
31577960-5	2019	Then, we will debate the NLRP3 inflammasome putting the focus on its activation through the canonical, non-canonical and alternative pathways and the triggers involved herein namely endoplasmic reticulum stress, mitochondrial dysfunction, reactive oxygen species and amyloid beta peptide.	Oxygen	248-254	NLR family pyrin domain containing 3	Homo sapiens	25-30
31509440-6	2019	Furthermore, Bnip3 downregulation altered the structure (electron density) and function (cellular ATP levels, membrane potential, and reacitve oxygen species generation) of mitochondria and decreased expression of cytoskeleton proteins vinculin, paxillin, and actinin.	Oxygen	143-149	BCL2 interacting protein 3	Homo sapiens	13-18
31788331-4	2019	Meanwhile, the activities of glutathione S-transferase and superoxide dismutase are significantly enhanced, and the reaction oxygen species content is reduced concomitantly.	Oxygen	125-131	glutathione S-transferase delta 1	Bombyx mori	29-54
31580991-4	2019	The reactive oxygen species (ROS) promoted histone acetylation mediated-Snail regulating the expression of E-cad after Oxy-PAHs treatment.	Oxygen	13-19	cadherin 1	Homo sapiens	107-112
30873870-8	2019	Moreover, after pretreatment with N-acetyl-cysteine, Shikonin increased the production of reactive oxygen species that are involved in regulating ER stress-mediated apoptosis and p38-activated autophagy, as evidenced by the reversion of cell viability and apoptosis and a decrease in p-eIF2alpha, CHOP, p-p38, LC3B-II, and Beclin 1 levels.	Oxygen	99-105	mitogen-activated protein kinase 14	Homo sapiens	179-182
31493379-7	2019	Biochemical and laboratory tests described a hyper unstable Hb variant with altered oxygen affinity that was clinically significant only when co-inherited with genetic defects affecting the alpha2 locus.	Oxygen	84-90	glycoprotein hormone subunit alpha 2	Homo sapiens	190-196
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	NLR family pyrin domain containing 3	Homo sapiens	244-249
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	signal transducer and activator of transcription 3	Homo sapiens	266-271
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	proteasome 20S subunit alpha 2	Homo sapiens	375-380
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	NLR family pyrin domain containing 3	Homo sapiens	244-249
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	signal transducer and activator of transcription 3	Homo sapiens	266-271
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	proteasome 20S subunit alpha 2	Homo sapiens	375-380
31556307-6	2019	CTRP3 also attenuated HG-induced oxidative stress in ARPE-19 cells with decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and increased superoxide dismutase (SOD) activity.	Oxygen	101-107	C1q and TNF related 3	Homo sapiens	0-5
31654346-4	2019	The purpose of this research was to clarify the relation between thioredoxin-interacting protein (TXNIP) and reactive oxygen species (ROS) in the placenta of patients with GDM, which has thus far remained unclear.	Oxygen	118-124	thioredoxin interacting protein	Homo sapiens	65-96
31654346-4	2019	The purpose of this research was to clarify the relation between thioredoxin-interacting protein (TXNIP) and reactive oxygen species (ROS) in the placenta of patients with GDM, which has thus far remained unclear.	Oxygen	118-124	thioredoxin interacting protein	Homo sapiens	98-103
31378559-3	2019	Although conventionally thought to be generated by mitochondria, reactive oxygen species during status epilepticus and prolonged seizure are generated mainly by NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (stimulated by NMDA receptor activation).	Oxygen	74-80	dual oxidase 2	Homo sapiens	168-220
31605506-4	2019	Furthermore, NGF suppressed the production of reactive oxygen species (ROS) and promoted antioxidant function via Abeta25-35.	Oxygen	55-61	nerve growth factor	Homo sapiens	13-16
31570002-6	2019	Both S47-phosphorylated and phosphomimetic Cytc showed a lower oxygen consumption rate in reaction with isolated Cytc oxidase, which we propose maintains intermediate mitochondrial membrane potentials under physiologic conditions, thus minimizing production of reactive oxygen species.	Oxygen	63-69	cytochrome c, somatic	Homo sapiens	43-47
31570002-6	2019	Both S47-phosphorylated and phosphomimetic Cytc showed a lower oxygen consumption rate in reaction with isolated Cytc oxidase, which we propose maintains intermediate mitochondrial membrane potentials under physiologic conditions, thus minimizing production of reactive oxygen species.	Oxygen	63-69	cytochrome c, somatic	Homo sapiens	113-117
31570002-6	2019	Both S47-phosphorylated and phosphomimetic Cytc showed a lower oxygen consumption rate in reaction with isolated Cytc oxidase, which we propose maintains intermediate mitochondrial membrane potentials under physiologic conditions, thus minimizing production of reactive oxygen species.	Oxygen	270-276	cytochrome c, somatic	Homo sapiens	43-47
31365782-6	2019	In primary astrocyte cultures, the microRNA miR-424 was found to target nuclear factor IA (NFIA); miR-424 agomir increased DNMT1 and H3K27me3 levels in U87 cells subjected to oxygen and glucose deprivation and induced cell cycle arrest in primary astrocytes while suppressing reactive astrocytosis, thereby preserving the structure of neurons and their axons in MCAO mice.	Oxygen	175-181	DNA methyltransferase (cytosine-5) 1	Mus musculus	123-128
31570002-6	2019	Both S47-phosphorylated and phosphomimetic Cytc showed a lower oxygen consumption rate in reaction with isolated Cytc oxidase, which we propose maintains intermediate mitochondrial membrane potentials under physiologic conditions, thus minimizing production of reactive oxygen species.	Oxygen	270-276	cytochrome c, somatic	Homo sapiens	113-117
31686134-5	2019	In addition, a decreased level of reactive oxygen species was found in Dgp-1[843K] mutant males maintained under stress conditions.	Oxygen	43-49	Dgp-1	Drosophila melanogaster	71-76
31634788-5	2019	Exposure of mouse hippocampal HT22 neurons to conditioned media from LPS + IFNgamma-stimulated BV-2 cells resulted in reduced cell viability and generation of cellular reactive oxygen species.	Oxygen	177-183	interferon gamma	Mus musculus	75-83
31670091-2	2019	This synthetic pyrazolone derivative is a potent scavenger of oxygen free radicals and also functions as a modulator of transcription factors, repressing NFkappaB and activating Nrf2, to regulate oxidative stress.	Oxygen	62-68	NFE2 like bZIP transcription factor 2	Homo sapiens	178-182
31871426-11	2019	Further experiments revealed that pyroptosis and the downstream inflammatory response in AS induced by IRF-1 is a process that is dependent on reactive oxygen species (ROS) generation.	Oxygen	152-158	interferon regulatory factor 1	Homo sapiens	103-108
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	178-182
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	56-60
31446614-7	2019	Hypoxia (5% O2, 5% CO2, 90% humidity) treatment for 6 h and 12 h induced HSP27, HSP32, and HSP70 expression.	Oxygen	12-14	heme oxygenase 1	Mus musculus	80-85
31446614-7	2019	Hypoxia (5% O2, 5% CO2, 90% humidity) treatment for 6 h and 12 h induced HSP27, HSP32, and HSP70 expression.	Oxygen	12-14	heat shock protein 1B	Mus musculus	91-96
31585129-2	2019	As an intermediate metabolite of 1,2-DCE in vivo, 2-chloroethanol (2-CE) can be transformed into chloroacetaldehyde and reactive oxygen species (ROS) through cytochrome P450 2E1 (CYP2E1) mediated metabolism.	Oxygen	129-135	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	158-177
31544319-6	2019	However, the expression of NOTCH1 and E2F1 was higher in female embryos cultured in high oxygen level.	Oxygen	89-95	E2F transcription factor 1	Bos taurus	38-42
31585129-2	2019	As an intermediate metabolite of 1,2-DCE in vivo, 2-chloroethanol (2-CE) can be transformed into chloroacetaldehyde and reactive oxygen species (ROS) through cytochrome P450 2E1 (CYP2E1) mediated metabolism.	Oxygen	129-135	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	179-185
31883232-8	2019	Moreover, oxygen consumption was higher in CA than in NCA (p < .001, d = 0.8).	Oxygen	10-16	CEA cell adhesion molecule 4	Homo sapiens	54-57
31788060-8	2019	Furthermore, it was identified p38 signaling (a major contributor to the response to reactive oxygen species generated by hypoxic stress), but not hypoxia-induced factor, as a key regulator of macrophages under hypoxia.	Oxygen	94-100	mitogen-activated protein kinase 14	Homo sapiens	31-34
31442335-0	2019	Effect of beta2 -adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men.	Oxygen	71-77	ATPase H+ transporting V0 subunit a2	Homo sapiens	10-15
31617338-4	2019	Here, we present evidence that the PI3K-AKTmTOR-reactive oxygen species-p53 pathway is necessary for CK2 downregulation-mediated H3K9me3 and SAHFs formation.	Oxygen	57-63	tumor protein p53	Homo sapiens	72-75
32245933-4	2019	In 180 min EF reaction, the removal rate of chemical oxygen demand (COD) in GF-0, GF-1 and GF-2 EF systems was 31.88%, 60.65% and 52.08% respectively; the removal rate of NH4+-N in GF-0, GF-1 and GF-2 EF systems was 43.37%, 98.10% and 94.81% respectively.	Oxygen	53-59	GATA binding protein 1	Homo sapiens	82-86
32245933-4	2019	In 180 min EF reaction, the removal rate of chemical oxygen demand (COD) in GF-0, GF-1 and GF-2 EF systems was 31.88%, 60.65% and 52.08% respectively; the removal rate of NH4+-N in GF-0, GF-1 and GF-2 EF systems was 43.37%, 98.10% and 94.81% respectively.	Oxygen	53-59	GATA binding protein 1	Homo sapiens	187-191
31658511-3	2019	Methods and Results: In this study, we found that the PVC secretome effectively alleviates secretion of both caspase-1 and interleukin-1beta in lipopolysaccharide-primed and activated human and murine macrophages by blocking inflammasome activation and attenuating the production of mitochondrial reactive oxygen species (ROS).	Oxygen	306-312	caspase 1	Homo sapiens	109-118
31658511-3	2019	Methods and Results: In this study, we found that the PVC secretome effectively alleviates secretion of both caspase-1 and interleukin-1beta in lipopolysaccharide-primed and activated human and murine macrophages by blocking inflammasome activation and attenuating the production of mitochondrial reactive oxygen species (ROS).	Oxygen	306-312	interleukin 1 beta	Homo sapiens	123-140
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Oxygen	130-136	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31919321-1	2019	Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a major source of reactive oxygen species (ROS) in the cardiovascular system.	Oxygen	88-94	dual oxidase 2	Homo sapiens	0-51
31885781-10	2019	In conclusion, HIF-1alpha, F2RL1, and PIK3CB may act as novel drivers for vitiligo, which are all closely associated with reactive oxygen species and possibly contribute to the activation and/or migration of melanocyte-specific CD8+ T cells in vitiligo.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
31885799-2	2019	Intracellular reactive oxygen species generation induces the activation of NF-kappaB via the inhibitor of kappaB (IkappaB) kinase (IKK) complex signaling.	Oxygen	23-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
31754158-0	2019	The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli.	Oxygen	91-97	Enolase	Escherichia coli	57-64
31652065-0	2019	Induced Night-Vision by Singlet-Oxygen-Mediated Activation of Rhodopsin.	Oxygen	32-38	rhodopsin	Homo sapiens	62-71
31885775-3	2019	This study shows that CGRP activates the PI3K/AKT pathway, thereby inducing increased expression of Nrf2 and HO-1 and resulting in the decrease of reactive oxygen species and malondialdehyde levels and reduced neuronal apoptosis.	Oxygen	156-162	calcitonin related polypeptide alpha	Homo sapiens	22-26
31885775-3	2019	This study shows that CGRP activates the PI3K/AKT pathway, thereby inducing increased expression of Nrf2 and HO-1 and resulting in the decrease of reactive oxygen species and malondialdehyde levels and reduced neuronal apoptosis.	Oxygen	156-162	AKT serine/threonine kinase 1	Homo sapiens	46-49
31704904-7	2019	We also studied the regulation of oxygen-responsive cellular signalling pathways (Hypoxia inducible factor, unfolded protein response and mTOR pathway) since most of what we know comes from studies on cancerous mammalian cell lines.Arctic char, were exposed to a cumulative, graded hypoxia trials, for 3 hours at each air saturation level (100%, 50%, 30% and 15%).	Oxygen	34-40	mechanistic target of rapamycin kinase	Homo sapiens	138-142
31754158-2	2019	We report a molecular mechanism underlying the regulation of enolase (eno) expression by two endoribonucleases, RNase G and RNase III, the expression levels of which are modulated by oxygen availability in Escherichia coli.	Oxygen	183-189	Enolase	Escherichia coli	61-68
31611307-7	2019	N-acetyl-L-cysteine and mito-TEMPO blocked the induction of IL-1beta by inhibiting reactive oxygen species (ROS) with SAA treatment.	Oxygen	92-98	interleukin 1 beta	Mus musculus	60-68
31754158-2	2019	We report a molecular mechanism underlying the regulation of enolase (eno) expression by two endoribonucleases, RNase G and RNase III, the expression levels of which are modulated by oxygen availability in Escherichia coli.	Oxygen	183-189	Enolase	Escherichia coli	61-64
31754158-7	2019	Thereby, this posttranscriptional up-regulation of eno expression helps E. coli cells adjust their physiological reactions to oxygen-deficient metabolic modes.	Oxygen	126-132	Enolase	Escherichia coli	51-54
31606392-7	2019	During activation of NLRP3, the mitochondrial membrane potential (MMP) decreased, the opening rate of mitochondrial permeability transition pore (MPTP) increased, and the content of reactive oxygen species (ROS) increased.	Oxygen	191-197	NLR family pyrin domain containing 3	Homo sapiens	21-26
31819864-0	2019	Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP.	Oxygen	114-120	NLR family pyrin domain containing 3	Homo sapiens	56-61
31827678-7	2019	Since several years, the role of Nrf2 in hematopoiesis has been extensively studied, which has functional similarities of cellular oxygen sensor hypoxia-inducible factor-1 as transcriptional factors.	Oxygen	131-137	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
31803133-9	2019	Meanwhile, in the SH-SY5Y cell injury model, serpina3k at an optimal concentration (150 nM) inhibited the generation of intracellular reactive oxygen species, abrogated changes of the mitochondrial membrane potential, and reduced the phospho-extracellular regulated protein kinases (p-ERK)/ERK, phospho-P38 (p-P38)/P38, B cell lymphoma (Bcl)-2-associated X protein/Bcl-2, and cleaved caspase-3/caspase-3 ratios, thereby reducing the apoptosis rate.	Oxygen	143-149	serine (or cysteine) peptidase inhibitor, clade A, member 3K	Mus musculus	45-54
31814867-7	2019	In addition, an inhibition of AKT/mTORC1 activity was found after PP7 administration, and it seemed that the overproduction of reactive oxygen species (ROS) was responsible for this effect.	Oxygen	136-142	AKT serine/threonine kinase 1	Homo sapiens	30-33
31422944-0	2019	Electronic properties and oxygen reduction reaction catalytic activity of h-BeN2 and MgN2 by first-principles calculations.	Oxygen	26-32	mago homolog B, exon junction complex subunit	Homo sapiens	85-89
31725783-6	2019	Although Acss2 is predominantly cytosolic, a subset of the Acss2 cellular pool is enriched in the nucleus following oxygen or glucose deprivation.	Oxygen	116-122	acyl-CoA synthetase short-chain family member 1	Mus musculus	59-64
31739632-10	2019	Variables related to PGF at 36 weeks PMA were initial weight loss (%), need for oxygen and lower parenteral lipids in the first week.	Oxygen	80-86	placental growth factor	Homo sapiens	21-24
31814867-7	2019	In addition, an inhibition of AKT/mTORC1 activity was found after PP7 administration, and it seemed that the overproduction of reactive oxygen species (ROS) was responsible for this effect.	Oxygen	136-142	protein phosphatase with EF-hand domain 1	Homo sapiens	66-69
31827713-4	2019	A catalase is one of the crucial antioxidant enzymes that mitigates oxidative stress to a considerable extent by destroying cellular hydrogen peroxide to produce water and oxygen.	Oxygen	172-178	catalase	Homo sapiens	2-10
31526567-8	2019	Mechanistically, PRDX1-regulated cerebral I-R injury was through the promotion of toll-like receptor-4 (TLR4), as proved by the evidence that TLR4 suppression abrogated the exacerbated effect of TLR4 on inflammatory response and apoptosis in oxygen and glucose deprivation (OGD)-treated primary microglial cells.	Oxygen	242-248	toll-like receptor 4	Mus musculus	82-102
31526567-8	2019	Mechanistically, PRDX1-regulated cerebral I-R injury was through the promotion of toll-like receptor-4 (TLR4), as proved by the evidence that TLR4 suppression abrogated the exacerbated effect of TLR4 on inflammatory response and apoptosis in oxygen and glucose deprivation (OGD)-treated primary microglial cells.	Oxygen	242-248	toll-like receptor 4	Mus musculus	104-108
31526567-8	2019	Mechanistically, PRDX1-regulated cerebral I-R injury was through the promotion of toll-like receptor-4 (TLR4), as proved by the evidence that TLR4 suppression abrogated the exacerbated effect of TLR4 on inflammatory response and apoptosis in oxygen and glucose deprivation (OGD)-treated primary microglial cells.	Oxygen	242-248	toll-like receptor 4	Mus musculus	142-146
31526567-8	2019	Mechanistically, PRDX1-regulated cerebral I-R injury was through the promotion of toll-like receptor-4 (TLR4), as proved by the evidence that TLR4 suppression abrogated the exacerbated effect of TLR4 on inflammatory response and apoptosis in oxygen and glucose deprivation (OGD)-treated primary microglial cells.	Oxygen	242-248	toll-like receptor 4	Mus musculus	142-146
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	151-157	erythropoietin	Homo sapiens	194-197
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	266-272	erythropoietin	Homo sapiens	194-197
31717992-8	2019	Moreover, melatonin suppressed elevation of intracellular reactive oxygen species (ROS) levels in TGF-beta1-treated cells.	Oxygen	67-73	transforming growth factor beta 1	Homo sapiens	98-107
31718044-7	2019	This comprises impact of TGF-beta on liver fibrogenesis related biological processes, such as senescence, metabolism, reactive oxygen species generation, epigenetics, circadian rhythm, epithelial mesenchymal transition, and endothelial-mesenchymal transition.	Oxygen	127-133	transforming growth factor beta 1	Homo sapiens	25-33
31781040-2	2019	Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species.	Oxygen	188-194	catalase	Homo sapiens	36-44
31575661-1	2019	Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the Gi/o protein-coupled kappa opioid receptor (KOR), mu opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS).	Oxygen	249-255	mitogen-activated protein kinase 8	Homo sapiens	58-81
31575661-1	2019	Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the Gi/o protein-coupled kappa opioid receptor (KOR), mu opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS).	Oxygen	249-255	mitogen-activated protein kinase 8	Homo sapiens	83-86
31717375-5	2019	In the TAA-treated AML12 cells, the PGC-secretome significantly increased cell viability, promoted expression of proliferation-related markers, such as PCNA and p-STAT, and significantly reduced the levels of reactive oxygen species (ROS).	Oxygen	218-224	progastricsin (pepsinogen C)	Mus musculus	36-39
31781040-2	2019	Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species.	Oxygen	188-194	catalase	Homo sapiens	46-49
31698794-4	2019	Thereafter, elevated intracellular hydrogen peroxide, the main source of ROS, diffused into liposomes and encapsulated CAT catalyzed the decomposition of hydrogen peroxide into oxygen and water.	Oxygen	177-183	catalase	Mus musculus	119-122
31700102-5	2019	Herein, we report 12 DVL-1 lysine residues that show differential acetylation in response to changes in oxygen tension and deacetylase inhibition in triple-negative breast cancer (TNBC).	Oxygen	104-110	dishevelled segment polarity protein 1	Homo sapiens	21-26
31698802-4	2019	Furthermore, a defective CFTR appears to produce a redox imbalance in epithelial cells and extracellular fluids and to cause an abnormal generation of reactive oxygen species: as a consequence, oxidative stress has been implicated as a causative factor in the aetiology of the process.	Oxygen	160-166	CF transmembrane conductance regulator	Homo sapiens	25-29
31362200-0	2019	The distribution of Pb(II)/Cd(II) adsorption mechanisms on biochars from aqueous solution: Considering the increased oxygen functional groups by HCl treatment.	Oxygen	117-123	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
31689402-2	2019	Loss of the E-cadherin tumor suppressor protein enhanced cell invasion, but inhibited multiple steps in metastatic spread due to the accumulation of reactive oxygen species and induction of apoptosis.	Oxygen	158-164	cadherin 1	Homo sapiens	12-22
32312920-4	2019	Sirtuin 3 is a key protein for mitochondrial homeostasis, regulating a number of metabolic processes related mainly to the control of the level of reactive oxygen species.	Oxygen	156-162	sirtuin 3	Homo sapiens	0-9
31430465-0	2019	The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.	Oxygen	49-55	tumor protein p53	Homo sapiens	99-102
31760917-5	2019	The sections of the review are devoted to the studies of GAPDH inactivation by reactive oxygen species, glutathione, and glycating agents.	Oxygen	88-94	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-62
31760925-1	2019	Terminal oxidases of aerobic respiratory chains catalyze the transfer of electrons from the respiratory substrate, cytochrome c or quinol, to O2 with the formation of two H2O molecules.	Oxygen	142-144	cytochrome c, somatic	Homo sapiens	115-127
31635777-4	2019	The aim of this study was to investigate whether addition of 15 IU/mL each of SOD, CAT, and GPX to diluted stallion semen would ameliorate a reactive oxygen-mediated decrease in semen quality during 72 h of storage at 5  C. Ejaculates (n = 7) were divided in two aliquots and diluted in INRA 96 without (control) or with addition of antioxidants.	Oxygen	150-156	superoxide dismutase 1	Homo sapiens	78-81
31635777-4	2019	The aim of this study was to investigate whether addition of 15 IU/mL each of SOD, CAT, and GPX to diluted stallion semen would ameliorate a reactive oxygen-mediated decrease in semen quality during 72 h of storage at 5  C. Ejaculates (n = 7) were divided in two aliquots and diluted in INRA 96 without (control) or with addition of antioxidants.	Oxygen	150-156	catalase	Homo sapiens	83-86
31445464-0	2019	High erythropoietin may be associated with vascular complications in patients with secondary erythrocytosis caused by high oxygen affinity variant hemoglobin Coimbra.	Oxygen	123-129	erythropoietin	Homo sapiens	5-19
31362200-2	2019	The adsorption of Pb(II) and Cd(II) on biochars are mainly controlled by ion exchange, oxygen functional groups (OFGs) complexation, Pb(II)/Cd(II)-pi interactions, and precipitation with minerals.	Oxygen	87-93	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24
31362200-6	2019	Precipitation with minerals was the dominant mechanism for Pb(II) and Cd(II) removal, accounting for 80.61-89.03% and 53.57-75.84%, respectively, of the total adsorption as the pyrolysis temperature increased from 300  C to 700  C. As for oxygen functional groups complexation, the percentage of Pb(II) and Cd(II) removal were 4.76-8.55% and 11.34-29.59%, respectively.	Oxygen	239-245	submaxillary gland androgen regulated protein 3B	Homo sapiens	59-76
31362200-6	2019	Precipitation with minerals was the dominant mechanism for Pb(II) and Cd(II) removal, accounting for 80.61-89.03% and 53.57-75.84%, respectively, of the total adsorption as the pyrolysis temperature increased from 300  C to 700  C. As for oxygen functional groups complexation, the percentage of Pb(II) and Cd(II) removal were 4.76-8.55% and 11.34-29.59%, respectively.	Oxygen	239-245	submaxillary gland androgen regulated protein 3B	Homo sapiens	59-65
31520768-10	2019	ROS are mainly substrates of catalase and superoxide dismutase (H2O2 and O2 -).	Oxygen	66-68	catalase	Homo sapiens	29-37
31908895-13	2019	ATRX and TP53 are important nodes in the network and have potential links with the blood oxygen imbalance.	Oxygen	89-95	tumor protein p53	Homo sapiens	9-13
31483333-4	2019	O2 homeostasis is critically intertwined with erythropoietic response in blood loss and anemia and the hormones that modulate iron mobilization and RBC production (e.g., erythropoietin, erythroferrone, and hepcidin) are intriguing markers for the monitoring of transfusion effectiveness in acute and chronic settings.	Oxygen	0-2	erythropoietin	Homo sapiens	170-184
31446555-0	2019	Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway.	Oxygen	41-47	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
31610903-1	2019	BACKGROUND: Glutathione peroxidase 3 (GPX3) provides critical protection against reactive oxygen species (ROS) in cells.	Oxygen	90-96	glutathione peroxidase 3	Homo sapiens	12-36
31290706-1	2019	Purpose: This work investigates the effect of resveratrol and melatonin on structural and functional changes of two enzymes, lactate dehydrogenase (LDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), exposed to radiation-induced reactive oxygen species.Materials and methods: Solutions of dehydrogenases with or without antioxidants (resveratrol or melatonin) were irradiated with X-rays under the atmosphere of air and at room temperature (21 +- 2  C).	Oxygen	245-251	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	157-197
31485604-10	2019	In conclusion, to the best of our knowledge, the results of the present study demonstrated for the first time that overexpression of miRNA-200a-3p promoted inflammation in sepsis-induced brain injury through reactive oxygen species-induced NLRP3.	Oxygen	217-223	NLR family pyrin domain containing 3	Homo sapiens	240-245
30945283-0	2019	CXCL16 protects against oxygen and glucose deprivation-induced injury in human microvascular endothelial cells-1: Potential role in ischemic stroke.	Oxygen	24-30	C-X-C motif chemokine ligand 16	Homo sapiens	0-6
31310363-9	2019	The overexpression of GPX3 reduced the glucose uptake, extracellular lactic acid content, and extracellular acidification rate and increased the oxygen consumption rate level.	Oxygen	145-151	glutathione peroxidase 3	Homo sapiens	22-26
31725141-0	2019	PURL: Supplemental oxygen: More isn"t always better.	Oxygen	19-25	phosphoribosylformylglycinamidine synthase	Homo sapiens	0-4
31610903-1	2019	BACKGROUND: Glutathione peroxidase 3 (GPX3) provides critical protection against reactive oxygen species (ROS) in cells.	Oxygen	90-96	glutathione peroxidase 3	Homo sapiens	38-42
31577387-5	2019	As the result, such HSA-CAT NRs upon tumor accumulation would significantly attenuate tumor hypoxia by decomposing endogenous H2 O2 produced by cancer cells to molecular oxygen, and thereby remarkably improve the therapeutic efficacy of radionuclide 131 I.	Oxygen	170-176	catalase	Mus musculus	24-27
30585987-10	2019	In the in vitro experiments, TNF-alpha induced an increase in mitochondrial oxygen consumption, which was attenuated by landiolol, which could represent a mechanism for renal protection.	Oxygen	76-82	tumor necrosis factor	Rattus norvegicus	29-38
31671122-5	2019	Cellular oxygen consumption rates and respiratory control ratio were decreased in the LBSL patient; in addition, fragmentation of mitochondria was increased, while their tubular elongation and interconnectivity were decreased.	Oxygen	9-15	aspartyl-tRNA synthetase 2, mitochondrial	Homo sapiens	86-90
31665070-11	2019	The maximal oxygen uptake (mean +- SD) measured at baseline was 54.7 +- 4.1 ml min- 1 kg- 1.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	79-91
31673096-0	2019	Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate.	Oxygen	24-30	AKT serine/threonine kinase 1	Homo sapiens	98-101
31781232-11	2019	Moreover, PRP treatment ameliorated the survival and activated the proliferation of in vitro cultured MSC and that these effects were accompanied by an alteration of the MSC energetic metabolism including oxygen consumption rate and mitochondrial ATP production.	Oxygen	205-211	proline rich protein HaeIII subfamily 1	Mus musculus	10-13
31781234-4	2019	First, we found that FoxO1 overexpression reduced reactive oxygen species (ROS) accumulation, decreased malondialdehyde (MDA) levels, and elevated antioxidant potential under oxidative condition.	Oxygen	59-65	forkhead box O1	Homo sapiens	21-26
31772705-0	2019	Endotoxin Engages Mitochondrial Quality Control via an iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes.	Oxygen	69-75	nitric oxide synthase 2, inducible	Mus musculus	55-59
31736997-9	2019	Yeast one-hybrid (Y1H) assays and electrophoretic mobility shift assays (EMSAs) revealed that GhWRKY91 directly targets GhWRKY17, a gene associated with ABA signals and reactive oxygen species (ROS) production.	Oxygen	178-184	probable WRKY transcription factor 46	Gossypium hirsutum	120-128
31646893-8	2021	Partial correlation analysis showed that the mean least oxygen saturation was significantly correlated with CRP after adjustment for BMI Pearson"s correlation coefficients examining the relationship between BMI and total cholesterol; TG and CRP were found to be 0.531, 0.401, and 0.321.	Oxygen	56-62	C-reactive protein	Homo sapiens	108-111
31646893-8	2021	Partial correlation analysis showed that the mean least oxygen saturation was significantly correlated with CRP after adjustment for BMI Pearson"s correlation coefficients examining the relationship between BMI and total cholesterol; TG and CRP were found to be 0.531, 0.401, and 0.321.	Oxygen	56-62	C-reactive protein	Homo sapiens	241-244
31646893-9	2021	The correlation of CRP levels with disease severity as assessed by RDI, ESS, and least oxygen saturation was significant after adjustment for BMI.	Oxygen	87-93	C-reactive protein	Homo sapiens	19-22
31772705-4	2019	Herein, we hypothesized that endotoxin-induced changes in hepatocyte mitochondrial respiration and homeostasis are regulated by an inducible nitric oxide synthase/nitric oxide (iNOS/NO)-mitochondrial reactive oxygen species (mtROS) signaling axis, involving activation of the NRF2 signaling pathway.	Oxygen	209-215	nitric oxide synthase 2, inducible	Mus musculus	131-162
31772705-4	2019	Herein, we hypothesized that endotoxin-induced changes in hepatocyte mitochondrial respiration and homeostasis are regulated by an inducible nitric oxide synthase/nitric oxide (iNOS/NO)-mitochondrial reactive oxygen species (mtROS) signaling axis, involving activation of the NRF2 signaling pathway.	Oxygen	209-215	nitric oxide synthase 2, inducible	Mus musculus	177-181
31772705-4	2019	Herein, we hypothesized that endotoxin-induced changes in hepatocyte mitochondrial respiration and homeostasis are regulated by an inducible nitric oxide synthase/nitric oxide (iNOS/NO)-mitochondrial reactive oxygen species (mtROS) signaling axis, involving activation of the NRF2 signaling pathway.	Oxygen	209-215	nuclear factor, erythroid derived 2, like 2	Mus musculus	276-280
31652571-6	2019	In glyI4 mutant plants, we observed a general stress phenotype, characterized by compromised MG scavenging, accumulation of reactive oxygen species (ROS), stomatal closure, and reduced fitness.	Oxygen	133-139	Lactoylglutathione lyase / glyoxalase I family protein	Arabidopsis thaliana	3-8
31560359-4	2019	Since the azobenzene units in the AMOFs can be reduced to amines by the highly expressed azoreductase in an oxygen-deficient environment, the VEGF mRNA-targeted molecular beacon (MB), which is adsorbed on the surface of AMOFs via electrostatic interactions, can be released due to the structural damage of AMOFs.	Oxygen	108-114	vascular endothelial growth factor A	Homo sapiens	142-146
31625633-0	2019	Understanding the Role of Solvents and Spin-Orbit Coupling in an Aerial Oxygen Assisted SN2 Type Oxidative Transmetalation Reaction.	Oxygen	72-78	solute carrier family 38 member 5	Homo sapiens	88-91
31762805-1	2019	HIF-1alpha (hypoxia-inducible factor-1alpha) is a transcriptional factor that participates in the regulation of oxygen homeostasis.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
31658548-11	2019	The content of TNF-alpha in wound granulation tissue after 7 days of treatment with VSD combined with irrigation of oxygen-loaded fluid was (10.1+-2.9) pg/L, significantly lower than (73.6+-5.6) pg/L before lesion resection (t=33.47, P&lt;0.01).	Oxygen	116-122	tumor necrosis factor	Homo sapiens	15-24
31615975-3	2019	Thioredoxin-interacting protein (TXNIP) promotes cellular oxidative stress by inhibiting thioredoxin reducing capacity and is in turn inversely regulated by reactive oxygen species levels; however, its role in oxidative stress-induced RPE cell dysfunction and the mechanistic link between TXNIP and autophagy are largely unknown.	Oxygen	166-172	thioredoxin interacting protein	Homo sapiens	0-31
31615975-3	2019	Thioredoxin-interacting protein (TXNIP) promotes cellular oxidative stress by inhibiting thioredoxin reducing capacity and is in turn inversely regulated by reactive oxygen species levels; however, its role in oxidative stress-induced RPE cell dysfunction and the mechanistic link between TXNIP and autophagy are largely unknown.	Oxygen	166-172	thioredoxin interacting protein	Homo sapiens	33-38
31615975-3	2019	Thioredoxin-interacting protein (TXNIP) promotes cellular oxidative stress by inhibiting thioredoxin reducing capacity and is in turn inversely regulated by reactive oxygen species levels; however, its role in oxidative stress-induced RPE cell dysfunction and the mechanistic link between TXNIP and autophagy are largely unknown.	Oxygen	166-172	thioredoxin interacting protein	Homo sapiens	289-294
31762805-1	2019	HIF-1alpha (hypoxia-inducible factor-1alpha) is a transcriptional factor that participates in the regulation of oxygen homeostasis.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
31680961-7	2019	This study investigated the reversal effect of PL both in vitro and in vivo, and provided evidence that PL inhibited the phosphorylation of Akt via the accumulation of reactive oxygen species in chemotherapy resistance cells.	Oxygen	177-183	AKT serine/threonine kinase 1	Homo sapiens	140-143
31611596-8	2019	Luseogliflozin suppressed the oxygen consumption rate in HRPTECs, and subsequently decreased hypoxia-sensitive dye, pimonidazole staining under hypoxia, suggesting that luseogliflozin promoted the degradation of HIF-1alpha protein by redistribution of intracellular oxygen.	Oxygen	266-272	hypoxia inducible factor 1 subunit alpha	Homo sapiens	212-222
31444841-0	2019	Construction of a sp3 /sp2 Carbon Interface in 3D N-Doped Nanocarbons for the Oxygen Reduction Reaction.	Oxygen	78-84	Sp3 transcription factor	Homo sapiens	18-21
31444841-0	2019	Construction of a sp3 /sp2 Carbon Interface in 3D N-Doped Nanocarbons for the Oxygen Reduction Reaction.	Oxygen	78-84	Sp2 transcription factor	Homo sapiens	23-26
31531426-0	2019	Photo- and dioxygen-enabled radical C(sp3)-N(sp2) cross-coupling between guanidines and perfluoroalkyl iodides.	Oxygen	11-19	Sp2 transcription factor	Homo sapiens	45-48
31605522-6	2019	RESULTS: DL had the highest maximal oxygen uptake (42.3 mL min-1 kg-1) ever observed for a female older than 80 years of age, which gave her a remarkable physiological age (27 y).	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	59-69
31681307-5	2019	NLRX1 has been shown to negatively regulate type-I interferon, attenuate pro-inflammatory NF-kappaB signaling, promote reactive oxygen species production, and modulate autophagy, cell death, and proliferation.	Oxygen	128-134	NLR family member X1	Mus musculus	0-5
31632061-11	2019	Besides, the results showed that the reactive oxygen species (ROS) levels increase when inhibiting RBPJ.	Oxygen	46-52	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	99-103
31594932-6	2019	These include sequential activation of endosomal escape through photochemical-internalization for enhanced cellular uptake, followed by photocontrolled gene knockdown of superoxide dismutase-1 to increase sensitivity to reactive oxygen species and finally, photodynamic therapy under these favorable conditions.	Oxygen	229-235	superoxide dismutase 1	Homo sapiens	170-192
31535110-0	2019	Identification of oxygen diffusion mechanisms in Nd1-xAExBaInO4-x/2 (AE = Ca, Sr, Ba) compounds through molecular dynamics.	Oxygen	18-24	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	49-52
31535110-3	2019	In this work, Nd1-xAExBaInO4-x/2 (AE = Ca, Sr, Ba) compounds have been studied by MD simulations focusing on oxygen diffusion mechanisms.	Oxygen	109-115	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	14-17
31548395-1	2019	The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange surface and allows passive diffusion of oxygen into the blood stream.	Oxygen	135-141	angiotensin II receptor, type 1a	Mus musculus	42-45
31687078-3	2019	ER stress has been found to affect NLRP3 inflammasome activation through multiple effects including the unfolded protein response (UPR), calcium or lipid metabolism, and reactive oxygen species (ROS) generation.	Oxygen	179-185	NLR family pyrin domain containing 3	Homo sapiens	35-40
31282122-2	2019	Herein we report the use of O2 as an external stimulus to switch the polymerization mechanism from the radical polymerization of vinyl monomers mediated by (Salen)CoIII -R [Salen=N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine; R=alkyl] to the ring-opening copolymerization (ROCOP) of CO2 /epoxides.	Oxygen	28-30	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	163-168
31557421-3	2019	Reported is a biocompatible and biodegradable catalase-conjugated iron oxide nanoparticle (Cat-IONP) capable of converting reactive oxygen species to molecular oxygen to supply an oxygen source for the hypoxic tumor microenvironment.	Oxygen	132-138	catalase	Homo sapiens	46-54
31557421-3	2019	Reported is a biocompatible and biodegradable catalase-conjugated iron oxide nanoparticle (Cat-IONP) capable of converting reactive oxygen species to molecular oxygen to supply an oxygen source for the hypoxic tumor microenvironment.	Oxygen	160-166	catalase	Homo sapiens	46-54
31135464-10	2019	Hyperbaric oxygen reduced the inflammatory reaction and glial scar formation by inhibiting inflammation-related factors iNOS and COX-2 and glial scar-related components GFAP and NG2.	Oxygen	11-17	nitric oxide synthase 2	Rattus norvegicus	120-124
31432707-13	2019	These data demonstrate that chronic subclinical TLR4 activation impairs afferent arteriolar autoregulatory behavior through mechanisms involving reactive oxygen species and major histocompatibility complex class II activation.	Oxygen	154-160	toll-like receptor 4	Rattus norvegicus	48-52
31388826-4	2019	Exposure to 100% oxygen for 72 h in male C57BL/6 mice resulted in increased protein levels of tumor necrosis factor-alpha and interleukin-1beta in lung tissues, and aggravated lung histological alterations.	Oxygen	17-23	tumor necrosis factor	Mus musculus	94-121
31581413-1	2019	Based on the antioxidative effect of resveratrol (RES) in mitigating reactive oxygen species (ROS) production through the induction of nuclear factor-erythroid 2-related factor-2 (Nrf2)/heme oxigenase-1 (HO-1) signaling pathway, we investigated whether the protective activity of RES against ROS-mediated cytotoxicity is mediated by intracellular carbon monoxide (CO), a product of HO-1 activity, in ultraviolet B (UVB)-irradiated human keratinocyte HaCaT cells.	Oxygen	78-84	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
31388826-4	2019	Exposure to 100% oxygen for 72 h in male C57BL/6 mice resulted in increased protein levels of tumor necrosis factor-alpha and interleukin-1beta in lung tissues, and aggravated lung histological alterations.	Oxygen	17-23	interleukin 1 beta	Mus musculus	126-143
31339770-0	2019	Improved exercise capacity in cyclophilin-D knockout mice associated with enhanced oxygen utilization efficiency and augmented glucose uptake via AMPK-TBC1D1 signaling nexus.	Oxygen	83-89	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	30-43
31402373-7	2019	Simultaneously, CaO2 could significantly downregulate multidrug resistance-associated protein 2 (MRP2) by O2-dependent hypoxia-inducible factor 1 (HIF-1) inactivation.	Oxygen	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-145
31402373-7	2019	Simultaneously, CaO2 could significantly downregulate multidrug resistance-associated protein 2 (MRP2) by O2-dependent hypoxia-inducible factor 1 (HIF-1) inactivation.	Oxygen	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-152
31374455-4	2019	OBJECTIVE: To determine whether premature infants treated with erythropoietin (Epo) in the neonatal period for anemia had a lower incidence of bronchopulmonary dysplasia (BPD), defined as oxygen need at 36 weeks postmenstrual age, and lower rehospitalization rates in the first year of life than infants not exposed.	Oxygen	188-194	erythropoietin	Homo sapiens	63-77
31374455-4	2019	OBJECTIVE: To determine whether premature infants treated with erythropoietin (Epo) in the neonatal period for anemia had a lower incidence of bronchopulmonary dysplasia (BPD), defined as oxygen need at 36 weeks postmenstrual age, and lower rehospitalization rates in the first year of life than infants not exposed.	Oxygen	188-194	erythropoietin	Homo sapiens	79-82
31099025-5	2019	Moreover, PFB@PLLA loads high amount of oxygen and US-triggering PFB@PLLA reoxygenation effectively inhibits the expression of hypoxia-related proteins (HIF-1alpha and CAIX), reduces lactate secretion and glycolysis, which modulates hypoxic microenvironment and inhibits cancer cell migration and invasion in vitro.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
31476902-4	2019	The current study sought to investigate the role of TLR4 signaling in neonatal oxygen-induced cardiomyopathy.	Oxygen	79-85	toll-like receptor 4	Rattus norvegicus	52-56
31476902-8	2019	At day 10, cardiac TLR4, Il (interleukin) 18, and Il1beta expression were increased in oxygen-exposed compared with room air controls.	Oxygen	87-93	toll-like receptor 4	Rattus norvegicus	19-23
31476902-8	2019	At day 10, cardiac TLR4, Il (interleukin) 18, and Il1beta expression were increased in oxygen-exposed compared with room air controls.	Oxygen	87-93	interleukin 1 beta	Rattus norvegicus	50-57
31476902-14	2019	This study indicates that neonatal exposure to high oxygen programs TLR4 activation, which contributes to cardiac remodeling and dysfunction.	Oxygen	52-58	toll-like receptor 4	Rattus norvegicus	68-72
31454684-3	2019	The enzyme nitric oxide synthase (NOS), responsible for the production of nitric oxide (NO), when uncoupled is as a source of O2-, for example by the absence of its cofactor tetrahydrobiopterin (BH4).	Oxygen	126-129	nitric oxide synthase 2	Homo sapiens	11-32
31425381-7	2019	SIRT3 deficiency in EC resulted in a significant decrease in glycolysis, whereas, it exhibited higher mitochondrial respiration and more prominent production of reactive oxygen species.	Oxygen	170-176	sirtuin 3	Homo sapiens	0-5
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hemoglobin subunit zeta	Gallus gallus	164-167
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hemoglobin subunit zeta	Gallus gallus	246-249
31392398-7	2019	GHRH-R antagonist increased basal and maximal oxygen consumption of cultured lung fibroblasts.	Oxygen	46-52	growth hormone releasing hormone receptor	Mus musculus	0-6
31398346-4	2019	Here, we found that in DCM patients, CD4+ T-cells exhibited immune dysfunction and glycolytic metabolic reprogramming based on extracellular acidification and oxygen consumption rates.	Oxygen	159-165	CD4 molecule	Homo sapiens	37-40
31694361-6	2019	Oxygen consumption and rating of perceived exertion were significantly higher in RAIN than in CON at 50 and 60 minutes (P&lt;0.05).	Oxygen	0-6	Ras interacting protein 1	Homo sapiens	81-85
31581560-9	2019	Although there was limited dissolved oxygen, aerobic degrading genes AlkB and Cdo were more abundant than anaerobic degrading genes AssA and BssA.	Oxygen	37-43	cell adhesion associated, oncogene regulated	Homo sapiens	78-81
31273612-7	2019	In antioxidant defence system, the superoxide dismutase (SOD) family is a first line antioxidant enzyme group involved in catalysing reactive oxygen species (ROS) to hydrogen peroxide and molecular oxygen.	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	35-55
31273612-7	2019	In antioxidant defence system, the superoxide dismutase (SOD) family is a first line antioxidant enzyme group involved in catalysing reactive oxygen species (ROS) to hydrogen peroxide and molecular oxygen.	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	57-60
31569523-0	2019	Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1alpha and the Upregulation of Reactive Oxygen Species in Tumor Cells.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
31488900-1	2019	Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of the classical physiological responses to hypoxia, led to the discovery of human oxygen-sensing mechanisms, which are now being targeted therapeutically.	Oxygen	174-180	erythropoietin	Homo sapiens	29-43
31488900-1	2019	Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of the classical physiological responses to hypoxia, led to the discovery of human oxygen-sensing mechanisms, which are now being targeted therapeutically.	Oxygen	174-180	erythropoietin	Homo sapiens	45-48
31557122-0	2019	Letter by Huttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".	Oxygen	120-126	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	46-52
31391251-6	2019	We found that the molecular switch involves a hydrogen bond interaction between Tyr-73 of mCD1d and the amide group oxygen of alphaGSAs.	Oxygen	116-122	CD1d1 antigen	Mus musculus	90-95
31662771-0	2019	SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells.	Oxygen	50-56	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
31557123-0	2019	Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".	Oxygen	140-146	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	66-72
31558702-6	2019	Mechanistically, HMGB1 binding with TLR2 receptor functions in a paracrine manner to affect CD133- pancreatic cancer cells dedifferentiation via activating Hippo-YAP pathway and HIF-1alpha expression in oxygen independent manner in vitro and in vivo.	Oxygen	203-209	toll like receptor 2	Homo sapiens	36-40
31476275-5	2019	Furthermore, theoretical calculations reveal that the optimization of the sp2 electronic structure of C C by amino radicals could effectively lower the kinetic formation barrier of the *O intermediate on the H2N-C C moiety, contributing to a prominent acidic oxygen-involved catalysis.	Oxygen	259-265	Sp2 transcription factor	Homo sapiens	74-77
31695774-8	2019	The enhanced tumor oxygenation after oxygen microbubble treatment inhibited hypoxia inducible factor-1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor vasculature.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-108
31554740-10	2019	The p.G2019S mutant Lrrk2 augmented immune cell chemotaxis and generated more reactive oxygen species during virulent infection.	Oxygen	87-93	leucine rich repeat kinase 2	Homo sapiens	20-25
31551405-0	2019	Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway.	Oxygen	128-134	fibroblast growth factor 2	Homo sapiens	0-30
31551405-0	2019	Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway.	Oxygen	128-134	fibroblast growth factor receptor 1	Homo sapiens	193-228
31551405-0	2019	Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway.	Oxygen	128-134	fibroblast growth factor receptor 1	Homo sapiens	230-235
31551405-0	2019	Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway.	Oxygen	128-134	mitogen-activated protein kinase 1	Homo sapiens	237-240
31551405-3	2019	This study aimed to investigate the role of bFGF in vitro in human brain microvascular endothelial cells (HBMECs) challenged by oxygen-glucose deprivation/reperfusion (OGD/R).	Oxygen	128-134	fibroblast growth factor 2	Homo sapiens	44-48
31695774-8	2019	The enhanced tumor oxygenation after oxygen microbubble treatment inhibited hypoxia inducible factor-1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor vasculature.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
31695774-8	2019	The enhanced tumor oxygenation after oxygen microbubble treatment inhibited hypoxia inducible factor-1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor vasculature.	Oxygen	19-25	vascular endothelial growth factor A	Homo sapiens	122-156
31309671-2	2019	Our experiments and density functional theory (DFT) calculations show the 3D p-FGDY/CC network is highly active and it is a high potential metal-free catalyst for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), as well as overall water splitting (OWS) under both acidic and alkaline conditions.	Oxygen	205-211	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	79-83
31695774-8	2019	The enhanced tumor oxygenation after oxygen microbubble treatment inhibited hypoxia inducible factor-1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor vasculature.	Oxygen	19-25	vascular endothelial growth factor A	Homo sapiens	158-162
31546731-5	2019	Furthermore, I3M remarkably increased the production of reactive oxygen species (ROS), which were reduced in transient p53 knockdown, indicating that I3M-mediated apoptosis was promoted by p53-mediated ROS production.	Oxygen	65-71	tumor protein p53	Homo sapiens	119-122
31072419-0	2019	Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma.	Oxygen	9-15	OTU deubiquitinase 7B	Homo sapiens	33-40
31576167-2	2019	MCOLN1, a reactive oxygen species sensor, can regulate autophagy via lysosomal Ca(2+); however, the role of MCOLN1 in NSCLC is largely unknown.	Oxygen	19-25	mucolipin TRP cation channel 1	Homo sapiens	0-6
31546731-5	2019	Furthermore, I3M remarkably increased the production of reactive oxygen species (ROS), which were reduced in transient p53 knockdown, indicating that I3M-mediated apoptosis was promoted by p53-mediated ROS production.	Oxygen	65-71	tumor protein p53	Homo sapiens	189-192
31546746-1	2019	: The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient-sensing pathway, constitute major targets for selective therapeutic intervention against several types of tumors, due to their extensive rewiring in cancer cells as compared to healthy cells.	Oxygen	29-35	mechanistic target of rapamycin kinase	Homo sapiens	154-158
31150877-4	2019	The results indicated that under long-term exposure to 5 mg L-1 tetracycline and 1 mg L-1 sulfamethoxazole, removals of chemical oxygen demand and total nitrogen were inhibited, the tendency of sludge bulking was increased, more filamentous bacteria were observed and more extracellular polymeric substance was secreted.	Oxygen	129-135	immunoglobulin kappa variable 1-16	Homo sapiens	60-82
31150877-4	2019	The results indicated that under long-term exposure to 5 mg L-1 tetracycline and 1 mg L-1 sulfamethoxazole, removals of chemical oxygen demand and total nitrogen were inhibited, the tendency of sludge bulking was increased, more filamentous bacteria were observed and more extracellular polymeric substance was secreted.	Oxygen	129-135	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
31540488-2	2019	Exposure of the oxygen transport protein horse heart myoglobin (hhMb) to HOCl inhibits Iron III (Fe(III))-heme reduction by cytochrome b5 to oxygen-binding Iron II (Fe(II))Mb.	Oxygen	16-22	myoglobin	Equus caballus	53-62
31540488-2	2019	Exposure of the oxygen transport protein horse heart myoglobin (hhMb) to HOCl inhibits Iron III (Fe(III))-heme reduction by cytochrome b5 to oxygen-binding Iron II (Fe(II))Mb.	Oxygen	141-147	myoglobin	Equus caballus	53-62
31407903-5	2019	Oxygen atom reactions occur more rapidly, generating complex product distributions; reaction pathways include associative electron detachment, substitution of the hydrogen atom by an oxygen atom, and generation of OCN-.	Oxygen	0-6	bone gamma-carboxyglutamate protein	Homo sapiens	214-217
31521090-5	2019	The isotropic ion images reveal that the NO-O2 system evolves through a long-lived NO3 collision complex prior to formation of products.	Oxygen	44-46	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
31607945-9	2019	The findings of the study suggest that small variations in training stimulus during the period of analysis and increases in maximal oxygen uptake result in improvements in the performance of trail running athletes when considering the running speed in the race.	Oxygen	132-138	TNF superfamily member 10	Homo sapiens	191-196
31555293-2	2019	Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in the detoxification of reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses.	Oxygen	120-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-43
31555293-2	2019	Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in the detoxification of reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses.	Oxygen	120-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	cereblon	Homo sapiens	0-4
31254862-2	2019	In this paper, we present a simple, label-free and signal-on electrochemiluminescence (ECL) aptasensor for the detection of amyloid-beta (Abeta) peptide using luminol as ECL emitter and in-situ generated reactive oxygen species (ROS) as coreactant via catalytic reaction between Cu2+-Abeta and the dissolved O2 in the presence of ascorbic acid (AA).	Oxygen	308-310	amyloid beta precursor protein	Homo sapiens	124-136
31254862-2	2019	In this paper, we present a simple, label-free and signal-on electrochemiluminescence (ECL) aptasensor for the detection of amyloid-beta (Abeta) peptide using luminol as ECL emitter and in-situ generated reactive oxygen species (ROS) as coreactant via catalytic reaction between Cu2+-Abeta and the dissolved O2 in the presence of ascorbic acid (AA).	Oxygen	308-310	amyloid beta precursor protein	Homo sapiens	138-143
31202990-4	2019	The hypothesis was verified by the increase of the intracellular reactive oxygen species, the decrease of mitochondrial membrane potential, the release of cytochrome C from the mitochondria into the cytoplasm, and the cascade activation of caspase-9 and caspase-3 when A549 cells were treated with 3a.	Oxygen	74-80	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	240-249
31519904-3	2019	Here, we show that muscle-specific HuR knockout (muHuR-KO) mice have high exercise endurance that is associated with enhanced oxygen consumption and carbon dioxide production.	Oxygen	126-132	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	35-38
31278893-12	2019	These results implied that exogenous NAD administration promoted Sirt5-mediated SDH-a desuccinylation and decreased the activity of SDH-a, which attenuated the succinate accumulation during ischemia and its depleting rate during reperfusion and finally alleviated reactive oxygen species generation.	Oxygen	273-279	sirtuin 5	Rattus norvegicus	65-70
31484989-5	2019	This result suggests that the immune signaling initiated by Mcp1 leads instead to the inhibition of cellular oxygen usage, for which mitochondrial respiration is an obvious target.	Oxygen	109-115	mast cell protease 1	Mus musculus	60-64
31582985-0	2019	Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha.	Oxygen	27-33	tumor necrosis factor	Homo sapiens	127-154
31582985-1	2019	Accumulation of reactive oxygen species (ROS), which can be induced by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), can significantly inhibit the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Oxygen	25-31	tumor necrosis factor	Homo sapiens	103-130
31582985-1	2019	Accumulation of reactive oxygen species (ROS), which can be induced by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), can significantly inhibit the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Oxygen	25-31	tumor necrosis factor	Homo sapiens	132-141
31327667-3	2019	MRE11A deficiency in RA T cells disrupted mitochondrial oxygen consumption and suppressed ATP generation.	Oxygen	56-62	MRE11 homolog, double strand break repair nuclease	Homo sapiens	0-6
31564830-0	2019	Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling.	Oxygen	53-59	FKBP prolyl isomerase 1B	Rattus norvegicus	166-174
31551713-10	2019	It lowered the cellular reactive oxygen species (ROS) level in C17.2 cells via Nuclear Factor Erythroid 2-Related Factor 1/2 (NRF1/2) - NAD(P)H Quinone Dehydrogenase 1 (NQO-1) - Heme Oxygenase 1 (HO-1) pathway.	Oxygen	33-39	nuclear factor, erythroid derived 2,-like 1	Mus musculus	79-124
31551713-10	2019	It lowered the cellular reactive oxygen species (ROS) level in C17.2 cells via Nuclear Factor Erythroid 2-Related Factor 1/2 (NRF1/2) - NAD(P)H Quinone Dehydrogenase 1 (NQO-1) - Heme Oxygenase 1 (HO-1) pathway.	Oxygen	33-39	nuclear respiratory factor 1	Mus musculus	126-132
31237976-10	2019	S100A8-induced IL-8 secretion was dependent on receptor RAGE, AP-1 activation, and reactive oxygen species production.	Oxygen	92-98	C-X-C motif chemokine ligand 8	Bos taurus	15-19
31485072-9	2019	Colony formation of E-cadherin-negative cells was rescued by inhibition of TGFbeta-receptor signalling, reactive oxygen accumulation or apoptosis.	Oxygen	113-119	cadherin 1	Homo sapiens	20-30
31047972-3	2019	When Abeta peptide (Abeta) is deposited on brain vessels, it induces vascular degeneration by producing reactive oxygen species and promoting inflammation.	Oxygen	113-119	amyloid beta precursor protein	Homo sapiens	5-10
31047972-3	2019	When Abeta peptide (Abeta) is deposited on brain vessels, it induces vascular degeneration by producing reactive oxygen species and promoting inflammation.	Oxygen	113-119	amyloid beta precursor protein	Homo sapiens	20-25
31202172-3	2019	2% O2 and 48 h were screened as optimal oxygen concentration and effect time, respectively, by determining cell apoptosis and mRNA expression of ASIC3, hypoxia inducible factor-1alpha (HIF-1alpha) and aquaporin 3.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-183
30908945-0	2019	Alterations in myocardial connexin-43 and matrix metalloproteinase-2 signaling in response to pregnancy and oxygen deprivation of Wistar rats: a pilot study 1.	Oxygen	108-114	gap junction protein, alpha 1	Rattus norvegicus	26-37
30696318-1	2019	Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis.	Oxygen	101-107	Hypoxia-inducible factor 1	Caenorhabditis elegans	12-38
30696318-1	2019	Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis.	Oxygen	101-107	Hypoxia-inducible factor 1	Caenorhabditis elegans	40-45
30696318-1	2019	Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis.	Oxygen	212-218	Hypoxia-inducible factor 1	Caenorhabditis elegans	12-38
30696318-1	2019	Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis.	Oxygen	212-218	Hypoxia-inducible factor 1	Caenorhabditis elegans	40-45
31239290-7	2019	Taken together, this study provided mechanistic insights into the oxygen-dependent modification of BRD4 and revealed new roles of the pathway in regulating BRD4-dependent gene expression.	Oxygen	66-72	bromodomain containing 4	Homo sapiens	99-103
31239290-7	2019	Taken together, this study provided mechanistic insights into the oxygen-dependent modification of BRD4 and revealed new roles of the pathway in regulating BRD4-dependent gene expression.	Oxygen	66-72	bromodomain containing 4	Homo sapiens	156-160
31162976-6	2019	Ischemic stress elicited by oxygen-glucose deprivation suppressed TGF-beta1-induced hyperpolarization and VSMC differentiation, but this effect was abolished by TRPC6 deletion.	Oxygen	28-34	transforming growth factor beta 1	Homo sapiens	66-75
31342141-1	2019	In order to shed light on metal-dependent mechanisms for O-O bond cleavage, and its microscopic reverse, we compare herein the electronic and geometric structures of O2-derived binuclear Co(III)- and Mn(III)-peroxo compounds.	Oxygen	166-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	187-194
31342141-1	2019	In order to shed light on metal-dependent mechanisms for O-O bond cleavage, and its microscopic reverse, we compare herein the electronic and geometric structures of O2-derived binuclear Co(III)- and Mn(III)-peroxo compounds.	Oxygen	166-168	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	190-193
31081255-8	2019	RESULTS: The test of phagocytosis function and production of reactive oxygen species showed that 200 ng/mL insulin treatment had a significant influence on antibacterial and production of reactive oxygen species.	Oxygen	70-76	insulin	Homo sapiens	107-114
31081255-8	2019	RESULTS: The test of phagocytosis function and production of reactive oxygen species showed that 200 ng/mL insulin treatment had a significant influence on antibacterial and production of reactive oxygen species.	Oxygen	197-203	insulin	Homo sapiens	107-114
31485072-10	2019	Our results reveal that E-cadherin acts as a survival factor in invasive ductal carcinomas during the detachment, systemic dissemination and seeding phases of metastasis by limiting reactive oxygen-mediated apoptosis.	Oxygen	191-197	cadherin 1	Homo sapiens	24-34
31470261-2	2019	Mice lacking the superoxide scavenger CuZnSOD (Sod1-/-) exhibit high levels of oxygen-derived radicals and oxidative damage, associated with neuronal and muscular phenotypes consistent with sarcopenia.	Oxygen	79-85	superoxide dismutase 1, soluble	Mus musculus	38-45
31299612-0	2019	Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1.	Oxygen	0-6	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	86-91
31108306-10	2019	Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group.	Oxygen	41-47	AKT serine/threonine kinase 1	Homo sapiens	216-220
31108306-10	2019	Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group.	Oxygen	41-47	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	227-267
31108306-10	2019	Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group.	Oxygen	41-47	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	269-274
31470261-2	2019	Mice lacking the superoxide scavenger CuZnSOD (Sod1-/-) exhibit high levels of oxygen-derived radicals and oxidative damage, associated with neuronal and muscular phenotypes consistent with sarcopenia.	Oxygen	79-85	superoxide dismutase 1, soluble	Mus musculus	47-51
31311815-8	2019	Platelets from old mice (where TNF-alpha was endogenously increased) and from young mice exposed to exogenous TNF-alpha exhibited significant mitochondrial changes characterized by elevated mitochondrial mass and increased oxygen consumption during activation.	Oxygen	223-229	tumor necrosis factor	Mus musculus	31-40
31311815-8	2019	Platelets from old mice (where TNF-alpha was endogenously increased) and from young mice exposed to exogenous TNF-alpha exhibited significant mitochondrial changes characterized by elevated mitochondrial mass and increased oxygen consumption during activation.	Oxygen	223-229	tumor necrosis factor	Mus musculus	110-119
31416223-1	2019	The conversion reaction of NO to NO3- ion catalyzed by the end-on [Cr(III)(n-TMC)(O2)(Cl)]+ superoxo and side-on [Cr(IV)(n-TMC)(O2)(Cl)]+ peroxo non-heme complexes (n = 12, 13, 14 and 15), which are biomimetic systems of nitric oxide dioxygenases (NODs), has been explored using a computational protocol in the framework of density functional theory.	Oxygen	82-84	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
31364628-14	2019	For temperatures between 200 K and 400 K we find several second-order phase transitions from one ice structure to another, changing in many cases both the arrangements of the oxygen atoms and the proton ordering.	Oxygen	175-181	caspase 1	Homo sapiens	97-100
31319025-2	2019	Superoxide dismutase (SOD) protects cells from superoxide-triggered apoptosis by converting superoxide to oxygen and peroxide.	Oxygen	106-112	superoxide dismutase 1	Homo sapiens	0-20
31319025-2	2019	Superoxide dismutase (SOD) protects cells from superoxide-triggered apoptosis by converting superoxide to oxygen and peroxide.	Oxygen	106-112	superoxide dismutase 1	Homo sapiens	22-25
31949512-2	2019	AIM: This study was conducted to demonstrate the ability of hyperbaric oxygen therapy (HBOT) as a complementary therapy in DFUs healing through raising vascular endothelial growth factor (VEGF) levels and suppressing tumour necrosis factor-alpha (TNF-alpha).	Oxygen	71-77	vascular endothelial growth factor A	Homo sapiens	152-186
31949512-2	2019	AIM: This study was conducted to demonstrate the ability of hyperbaric oxygen therapy (HBOT) as a complementary therapy in DFUs healing through raising vascular endothelial growth factor (VEGF) levels and suppressing tumour necrosis factor-alpha (TNF-alpha).	Oxygen	71-77	vascular endothelial growth factor A	Homo sapiens	188-192
31949512-2	2019	AIM: This study was conducted to demonstrate the ability of hyperbaric oxygen therapy (HBOT) as a complementary therapy in DFUs healing through raising vascular endothelial growth factor (VEGF) levels and suppressing tumour necrosis factor-alpha (TNF-alpha).	Oxygen	71-77	tumor necrosis factor	Homo sapiens	247-256
31251921-10	2019	Our results suggested that quercein could modulate NADPH oxidase-derived O2.- production in macrophages at least partly through HO-1 induction.	Oxygen	73-76	heme oxygenase 1	Mus musculus	128-132
31051337-6	2019	Finally, the adsorption mechanism of Pb(II) by RGO was proposed, Pb(II) was adsorbed on the surface of RGO via the electrons on the pi-bond on RGO and the interaction of Pb(II) with oxygen-containing functional groups, which were supported by the Fourier Transform Infrared and X-ray photoelectron spectroscopy results.	Oxygen	182-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	37-43
31051337-6	2019	Finally, the adsorption mechanism of Pb(II) by RGO was proposed, Pb(II) was adsorbed on the surface of RGO via the electrons on the pi-bond on RGO and the interaction of Pb(II) with oxygen-containing functional groups, which were supported by the Fourier Transform Infrared and X-ray photoelectron spectroscopy results.	Oxygen	182-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	65-71
31051337-6	2019	Finally, the adsorption mechanism of Pb(II) by RGO was proposed, Pb(II) was adsorbed on the surface of RGO via the electrons on the pi-bond on RGO and the interaction of Pb(II) with oxygen-containing functional groups, which were supported by the Fourier Transform Infrared and X-ray photoelectron spectroscopy results.	Oxygen	182-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	65-71
31482833-4	2019	All infants underwent a room air diagnostic sleep study (RA-PSG), followed by a sleep study while breathing supplemental oxygen via nasal cannula (O2-PSG) on a separate night.	Oxygen	147-149	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	150-153
31482833-7	2019	The mean age of infants at the time of RA-PSG was 13.0 +- 11.7 weeks and at O2-PSG was 15.4 +- 13.0 weeks.	Oxygen	76-78	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	79-82
31482833-8	2019	The obstructive AHI decreased from 19.7 +- 13.0 during RA-PSG to 10.6 +- 11.7 during O2-PSG (P < .001).	Oxygen	85-87	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	88-91
31453072-0	2019	Erratum: Co (II) Boron Imidazolate Framework with Rigid Auxiliary Linkers for Stable Electrocatalytic Oxygen Evolution Reaction.	Oxygen	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
30935870-4	2019	Traditionally, enzymes involved in primary oxygen metabolism such as cytochrome c, and reactive oxygen species (ROS)-neutralizing enzymes (e.g. catalase), were used as identifiers of oxygen phenotype.	Oxygen	43-49	cytochrome c, somatic	Homo sapiens	69-81
31235522-5	2019	Atg7 DeltaMye macrophages exhibited defective mitochondrial respiration and displayed elevated mitochondrial reactive oxygen species production and inflammasome activation relative to WT cells.	Oxygen	118-124	autophagy related 7	Mus musculus	0-4
31251921-5	2019	In RAW264.7 macrophages, quercetin significantly attenuated NADPH oxidase-derived O2.- generation via a HO-1-dependent mechanism.	Oxygen	82-84	heme oxygenase 1	Mus musculus	104-108
30980427-1	2019	RATIONALE: The nitrogen and oxygen (delta15 N, delta18 O, and delta17 O values) isotopic compositions of nitrate (NO3 - ) are crucial tracers of nutrient nitrogen (N) sources and dynamics in aquatic systems.	Oxygen	28-34	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
31416223-1	2019	The conversion reaction of NO to NO3- ion catalyzed by the end-on [Cr(III)(n-TMC)(O2)(Cl)]+ superoxo and side-on [Cr(IV)(n-TMC)(O2)(Cl)]+ peroxo non-heme complexes (n = 12, 13, 14 and 15), which are biomimetic systems of nitric oxide dioxygenases (NODs), has been explored using a computational protocol in the framework of density functional theory.	Oxygen	128-130	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
31304734-3	2019	From the surface chemical analysis, it is found that NO2 stably reconstructs surface chemical bonding with NO3- ions by capturing the charged electrons and oxygen and the regions with and without NO2 treatment display extreme differences in their electrical conductivity.	Oxygen	156-162	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
31411185-11	2019	Furthermore, pro-inflammatory cytokines IL-1ss, IL-6, and TNF-alpha were inhibited and anti-inflammatory cytokines IL-10 was increased in the lungs of rats in O2+Ad-hBD2 group.	Oxygen	159-162	defensin beta 4A	Homo sapiens	165-169
31389949-2	2019	In this study, bovine serum albumin (BSA) was hybridized with Mn2+via biomineralization to develop a hybrid protein oxygen nanocarrier, which contained doxorubicin (DOX) and small interfering RNA (siRNA).	Oxygen	116-122	albumin	Homo sapiens	22-35
31291107-5	2019	This study reveals the first member of a previously unidentified superfamily of TIM-barrel-fold enzymes for metal-dependent dioxygen activation, with the majority predicted to act on CoA-linked substrates, thus expanding our knowledge of nature"s repertoire of nonheme diiron monooxygenases and TIM-barrel-fold enzymes.	Oxygen	124-132	triosephosphate isomerase 1	Homo sapiens	80-83
31291107-5	2019	This study reveals the first member of a previously unidentified superfamily of TIM-barrel-fold enzymes for metal-dependent dioxygen activation, with the majority predicted to act on CoA-linked substrates, thus expanding our knowledge of nature"s repertoire of nonheme diiron monooxygenases and TIM-barrel-fold enzymes.	Oxygen	124-132	triosephosphate isomerase 1	Homo sapiens	295-298
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-211
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	213-223
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	63-69	vascular endothelial growth factor A	Homo sapiens	257-291
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	63-69	vascular endothelial growth factor A	Homo sapiens	293-297
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	19-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-211
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	19-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	213-223
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	19-21	vascular endothelial growth factor A	Homo sapiens	257-291
31389949-5	2019	Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated.	Oxygen	19-21	vascular endothelial growth factor A	Homo sapiens	293-297
31178138-10	2019	The suppressive effects of Trim47 knockdown on cerebral I/R were verified in human neuron-like cells stimulated by oxygen and glucose deprivation (OGD).	Oxygen	115-121	tripartite motif containing 47	Homo sapiens	27-33
31078990-6	2019	The surface oxygen content promoted the ability of GO to remove Pb(II).	Oxygen	12-18	submaxillary gland androgen regulated protein 3B	Homo sapiens	64-70
31646013-5	2019	Mechanistically, prolonged activation of Akt signaling caused an accumulation of reactive oxygen species and triggered chondrocyte senescence as well as a senescence-associated secretory phenotype, whereas chronic administration of the antioxidant N-acetylcysteine suppressed chondrocyte senescence and mitigated OA progression in PTEN-deficient mice.	Oxygen	90-96	thymoma viral proto-oncogene 1	Mus musculus	41-44
30355069-8	2019	In addition, Rpd3 and Hda1 may regulate the responsiveness to oxygen in isoamyl acetate production.	Oxygen	62-68	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	13-17
30690929-7	2019	The study demonstrated a correlation between venular retinal blood oxygen saturation and proangiogenic factors HGF (r = 0.558, p = 0.038), Ang2 (r = 0.556, p = 0.039) and EGF (r = -0.554, p = 0.040), but did not find any correlation for IL-8 (r = 0.330, p = 0.249) even though this biomarker was significantly higher in the diabetic group.	Oxygen	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
31188638-9	2019	Furthermore, COX activity and oxygen consumption were also diminished after SIRT3 knockdown.	Oxygen	30-36	sirtuin 3	Homo sapiens	76-81
30880408-7	2019	This new methodology enabled the quantitative assessment of the interaction of Pdi1p and Ero1p in vitro by measuring oxygen consumption and reoxidation of reduced RNase A.	Oxygen	117-123	ER oxidoreductin	Saccharomyces cerevisiae S288C	89-94
31234258-4	2019	A variety of characterizations indicated that oxygen containing groups were generated on CNT surface upon the oxidation, and the O/C ratio increased in the order of pristine CNT &lt; H2O2-CNT &lt; O3-CNT.	Oxygen	46-52	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	197-203
30959399-2	2019	a glucose/oxygen enzymatic fuel cell, with a charge-storing component, in which the redox features of the immobilized redox protein cytochrome c (cyt c) were utilized.	Oxygen	10-16	cytochrome c, somatic	Homo sapiens	132-144
30959399-2	2019	a glucose/oxygen enzymatic fuel cell, with a charge-storing component, in which the redox features of the immobilized redox protein cytochrome c (cyt c) were utilized.	Oxygen	10-16	cytochrome c, somatic	Homo sapiens	146-151
31292775-1	2019	Copper-zinc superoxide dismutase (Sod1) is a critical antioxidant enzyme that rids the cell of reactive oxygen through the redox cycling of a catalytic copper ion provided by its copper chaperone (Ccs).	Oxygen	104-110	superoxide dismutase 1	Homo sapiens	34-38
31026756-4	2019	Moreover, the incorporation of CIN or ZnO NPs to SPI matrix affected differently color parameters, oxygen permeability and storage modulus of the resulting composite films.	Oxygen	99-105	chromogranin A	Homo sapiens	49-52
31026756-7	2019	Meanwhile, the oxygen permeability and water permeability for SPI + CIN + ZnO film are 66.1% and 54.8% of that in regular SPI film, respectively.	Oxygen	15-21	chromogranin A	Homo sapiens	62-65
31152312-0	2019	Systemic Rho-kinase inhibition using fasudil in mice with oxygen-induced retinopathy.	Oxygen	58-64	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	9-19
31103492-3	2019	PC12 cells were treated with corticosterone with or without d-limonene for 24 h. Western blots were performed to measure activation of AMPK pathway members [Silent mating type information regulation 2 homolog-1 (SIRT1), AMPKalpha, and nuclear factor (NFkappaB)], reactive oxygen species, inflammatory cytokines, and markers of apoptosis.	Oxygen	272-278	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	135-139
31152312-1	2019	PURPOSE: To investigate the influence of the selective Rho-kinase (ROCK) inhibitor, fasudil, on the mRNA level of proinflammatory factors and the retinal vascular development in mice with oxygen-induced retinopathy (OIR).	Oxygen	188-194	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	55-65
31152312-1	2019	PURPOSE: To investigate the influence of the selective Rho-kinase (ROCK) inhibitor, fasudil, on the mRNA level of proinflammatory factors and the retinal vascular development in mice with oxygen-induced retinopathy (OIR).	Oxygen	188-194	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	67-71
31091460-9	2019	Finally, DHCR24 inhibition increased the levels of reactive oxygen species and cleaved caspase-3 after cisplatin-induced injury.	Oxygen	60-66	24-dehydrocholesterol reductase	Rattus norvegicus	9-15
31278195-4	2019	Mice lacking a receptor on their erythrocytes called ADORA2B, which increases O2 delivery, and patients with CKD were studied to assess the role of ADORA2B-mediated O2 delivery in CKD.	Oxygen	165-167	adenosine A2b receptor	Homo sapiens	148-155
31278195-10	2019	CONCLUSIONS: Mouse and human evidence reveals that ADORA2B-AMPK signaling cascade-induced 2,3-BPG production promotes O2 delivery by erythrocytes to counteract kidney hypoxia and progression of CKD.	Oxygen	118-120	adenosine A2b receptor	Homo sapiens	51-58
31363852-0	2019	Quadruply-labeled serum albumin as a biodegradable nanosensor for simultaneous fluorescence imaging of intracellular pH values, oxygen and temperature.	Oxygen	128-134	albumin	Homo sapiens	18-31
31363852-9	2019	Graphical abstractA triple nanosensor for simultaneously ratiometrically sensing intracellular pH, oxygen and temperature values was constructed by covalently labelling four fluorophores on a single serum albumin protein.	Oxygen	99-105	albumin	Homo sapiens	199-212
31357627-4	2019	Moreover, our data identify mitochondria as the main responsible sites for the alteration of calcium homeostasis induced by TDP-43 aggregates, which, in turn, stimulates an increase in reactive oxygen species and, finally, caspase activation.	Oxygen	194-200	TAR DNA binding protein	Homo sapiens	124-130
31173822-2	2019	Neuroglobin (Ngb) is a novel oxygen-carrying globulin that has been demonstrated to have neuroprotective effects in a variety of central nervous system disorders.	Oxygen	29-35	neuroglobin	Rattus norvegicus	0-11
31173822-2	2019	Neuroglobin (Ngb) is a novel oxygen-carrying globulin that has been demonstrated to have neuroprotective effects in a variety of central nervous system disorders.	Oxygen	29-35	neuroglobin	Rattus norvegicus	13-16
31313790-5	2019	Exposure to As(iii) and As(v) generates an increase in the release of the pro-inflammatory cytokine IL-8 (57-1135%) and an increase in the generation of reactive oxygen and/or nitrogen species (130-340%) in both cell lines.	Oxygen	162-168	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
31022534-1	2019	Nitric oxide synthase (NOS) catalyzes the transformation of l-arginine, molecular oxygen (O2), and NADPH-derived electrons to nitric oxide (NO) and l-citrulline.	Oxygen	82-88	nitric oxide synthase 2	Homo sapiens	0-21
31022534-1	2019	Nitric oxide synthase (NOS) catalyzes the transformation of l-arginine, molecular oxygen (O2), and NADPH-derived electrons to nitric oxide (NO) and l-citrulline.	Oxygen	90-92	nitric oxide synthase 2	Homo sapiens	0-21
31632627-7	2019	In addition, activity of the pathogenesis-related proteins glucanase (PR2) and chitinase (PR3), lipoxygenase and polyphenol oxidase was enhanced together with an increased capacity to remove reactive oxygen species (ROS).	Oxygen	99-105	beta-1,3-glucanase 2	Arabidopsis thaliana	70-73
31170466-0	2019	New concepts for transdermal delivery of oxygen based on catalase biochemical reactions studied by oxygen electrode amperometry.	Oxygen	41-47	catalase	Homo sapiens	57-65
31170466-0	2019	New concepts for transdermal delivery of oxygen based on catalase biochemical reactions studied by oxygen electrode amperometry.	Oxygen	99-105	catalase	Homo sapiens	57-65
31170466-2	2019	In this work we approach this topic by a novel strategy based on the antioxidative enzyme catalase, which is naturally present in the skin organ where it enables conversion of the reactive oxygen species hydrogen peroxide (H2O2) into O2.	Oxygen	189-195	catalase	Homo sapiens	90-98
31170466-2	2019	In this work we approach this topic by a novel strategy based on the antioxidative enzyme catalase, which is naturally present in the skin organ where it enables conversion of the reactive oxygen species hydrogen peroxide (H2O2) into O2.	Oxygen	225-227	catalase	Homo sapiens	90-98
31170466-3	2019	We introduce various applications of the skin covered oxygen electrode (SCOE) as an in-vitro tool for studies of catalase activity and function.	Oxygen	54-60	catalase	Homo sapiens	113-121
31170466-6	2019	The activity of native catalase in skin is sufficient to generate considerable amounts of O2 by conversion from H2O2 and proof-of-concept is presented for catalase-based transdermal O2 delivery from topical formulations containing H2O2.	Oxygen	90-92	catalase	Homo sapiens	23-31
31170466-6	2019	The activity of native catalase in skin is sufficient to generate considerable amounts of O2 by conversion from H2O2 and proof-of-concept is presented for catalase-based transdermal O2 delivery from topical formulations containing H2O2.	Oxygen	90-92	catalase	Homo sapiens	155-163
31170466-6	2019	The activity of native catalase in skin is sufficient to generate considerable amounts of O2 by conversion from H2O2 and proof-of-concept is presented for catalase-based transdermal O2 delivery from topical formulations containing H2O2.	Oxygen	114-116	catalase	Homo sapiens	23-31
31170466-6	2019	The activity of native catalase in skin is sufficient to generate considerable amounts of O2 by conversion from H2O2 and proof-of-concept is presented for catalase-based transdermal O2 delivery from topical formulations containing H2O2.	Oxygen	114-116	catalase	Homo sapiens	155-163
31170466-7	2019	In addition, we show that this concept can be further improved by topical application of external catalase on the skin surface, which enables transdermal O2 delivery from 50 times lower concentrations of H2O2.	Oxygen	154-156	catalase	Homo sapiens	98-106
31701714-10	2019	CONCLUSION: Hypoxia can affect the Nrf2 antioxidant system, and the different oxygen concentrations have different impact.	Oxygen	78-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
31170466-9	2019	Further, our results indicate that the O2 production by catalase, derived from topically applied S. epidermidis (a simple model for skin microbiota) is relatively low as compared to the O2 produced by the catalase naturally present in skin.	Oxygen	39-41	catalase	Homo sapiens	56-64
31170466-9	2019	Further, our results indicate that the O2 production by catalase, derived from topically applied S. epidermidis (a simple model for skin microbiota) is relatively low as compared to the O2 produced by the catalase naturally present in skin.	Oxygen	39-41	catalase	Homo sapiens	205-213
31170466-9	2019	Further, our results indicate that the O2 production by catalase, derived from topically applied S. epidermidis (a simple model for skin microbiota) is relatively low as compared to the O2 produced by the catalase naturally present in skin.	Oxygen	186-188	catalase	Homo sapiens	56-64
31170466-9	2019	Further, our results indicate that the O2 production by catalase, derived from topically applied S. epidermidis (a simple model for skin microbiota) is relatively low as compared to the O2 produced by the catalase naturally present in skin.	Oxygen	186-188	catalase	Homo sapiens	205-213
31701714-0	2019	[The antioxidant system mediated by Nrf2 in C2C12 cells responding to H2O2 stimulus under different oxygen concentration].	Oxygen	100-106	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-40
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	73-79	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
31229404-0	2019	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	Oxygen	3-9	F-box and leucine rich repeat protein 5	Homo sapiens	40-45
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	73-79	nuclear receptor coactivator 5	Homo sapiens	23-26
31229404-0	2019	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	Oxygen	3-9	nuclear receptor coactivator 5	Homo sapiens	54-57
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	81-83	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	81-83	nuclear receptor coactivator 5	Homo sapiens	23-26
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	nuclear receptor coactivator 5	Homo sapiens	23-26
31467861-5	2019	Here, we present a method for HCD cultivation of oxygenic phototrophs based on the co-cultivation of different trophies in a biofilm format to avoid high oxygen partial-pressure and attain HCDs of up to 51.8 gBDW L-1 on a lab scale.	Oxygen	49-55	immunoglobulin kappa variable 1-16	Homo sapiens	213-216
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
31251022-4	2019	The azobenzene units within the frameworks of AMOFs could be reduced to amines by the highly expressed azoreductase under the oxygen-deficient environment, which results in azoreductase-responsive release of the encapsulated drugs and siRNAs under the hypoxic condition.	Oxygen	126-132	NAD(P)H quinone dehydrogenase 1	Homo sapiens	103-115
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	nuclear receptor coactivator 5	Homo sapiens	23-26
31251022-4	2019	The azobenzene units within the frameworks of AMOFs could be reduced to amines by the highly expressed azoreductase under the oxygen-deficient environment, which results in azoreductase-responsive release of the encapsulated drugs and siRNAs under the hypoxic condition.	Oxygen	126-132	NAD(P)H quinone dehydrogenase 1	Homo sapiens	173-185
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	nuclear receptor coactivator 5	Homo sapiens	23-26
31332228-1	2019	The transcription factor HIF-1 induces the expression of genes that are essential for cell survival and oxygen homeostasis in hypoxic conditions.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-30
31337753-0	2019	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1alpha and HIF2alpha.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-98
31346243-1	2019	The Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme that catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide.	Oxygen	118-124	superoxide dismutase 1	Homo sapiens	32-36
30849228-7	2019	Increased neutrophil apoptosis in hypoxia, also observed with IL-13, required active STAT signaling, and was dependent on expression of the oxygen-sensing prolyl hydroxylase PHD2.	Oxygen	140-146	interleukin 13	Homo sapiens	62-67
31316111-0	2019	Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production.	Oxygen	143-149	kelch like ECH associated protein 1	Homo sapiens	14-19
31316111-0	2019	Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production.	Oxygen	143-149	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
31221773-5	2019	This was caused by Abeta generating reactive oxygen species, which evoked the release of endothelin-1 (ET) that activated pericyte ETA receptors.	Oxygen	45-51	amyloid beta precursor protein	Homo sapiens	19-24
31221773-5	2019	This was caused by Abeta generating reactive oxygen species, which evoked the release of endothelin-1 (ET) that activated pericyte ETA receptors.	Oxygen	45-51	endothelin 1	Homo sapiens	89-101
30849228-7	2019	Increased neutrophil apoptosis in hypoxia, also observed with IL-13, required active STAT signaling, and was dependent on expression of the oxygen-sensing prolyl hydroxylase PHD2.	Oxygen	140-146	egl-9 family hypoxia inducible factor 1	Homo sapiens	174-178
31087617-3	2019	The catalase triggered the decomposition of hydrogen peroxide to oxygen gas, hence propelling the autonomous motion of microshell motors.	Oxygen	65-71	catalase	Homo sapiens	4-12
31146911-0	2019	CXCL1 promotes the proliferation of neural stem cells by stimulating the generation of reactive oxygen species in APP/PS1 mice.	Oxygen	96-102	chemokine (C-X-C motif) ligand 1	Mus musculus	0-5
31108095-0	2019	Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.	Oxygen	11-17	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	93-97
31108095-14	2019	These findings suggest that hyperbaric oxygen therapy ameliorates spinal cord injury-induced neurological impairment by anti-apoptosis and suppressing dendritic/synaptic degeneration via upregulating the BDNF/TrkB signaling pathways.	Oxygen	39-45	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	209-213
31534494-5	2019	The shell was modified with catalase (E), which catalyzes the conversion of hydrogen peroxide to oxygen at the tumor site, alleviating hypoxia and increasing the effect of the photodynamic treatment.	Oxygen	97-103	catalase	Mus musculus	28-36
31300478-4	2019	Combination of alphaPDL1 nanoparticle treatment with near-infrared (NIR) laser irradiation-triggered activation of photosensitizer indocyanine green induces the generation of reactive oxygen species, which promotes the intratumoral infiltration of CTLs and sensitizes the tumors to PDL1 blockade therapy.	Oxygen	184-190	CD274 antigen	Mus musculus	20-24
31195793-9	2019	This study developed a hypoxia-responsive MSN with the azobenzene polymer as the removable gate-keeper, which would expand the application of MSNs in pharmaceutical and biomedical areas since the low oxygen concentration is a unique trigger in many pathological conditions.	Oxygen	200-206	moesin	Homo sapiens	42-45
31195793-2	2019	Herein, we report a gated smart MSN that is sensitive to low oxygen concentration (i.e., hypoxia) via taking advantage of the superior electron-accepting ability of the azobenzene moiety.	Oxygen	61-67	moesin	Homo sapiens	32-35
31284572-3	2019	The NLRP3 inflammasome is activated by diverse stimuli, and multiple molecular and cellular events, including ionic flux, mitochondrial dysfunction, and the production of reactive oxygen species, and lysosomal damage have been shown to trigger its activation.	Oxygen	180-186	NLR family pyrin domain containing 3	Homo sapiens	4-9
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	39-45	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	39-45	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	218-220	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	218-220	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	251-257	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Oxygen	251-257	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
31251057-5	2019	Subsequently, monodentate NO3- species decompose to NO2 to restore one of the lattice oxygen atoms that act as a reversible redox center, and the vacancy can easily activate O2 to replenish the consumed one.	Oxygen	86-92	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
31251057-5	2019	Subsequently, monodentate NO3- species decompose to NO2 to restore one of the lattice oxygen atoms that act as a reversible redox center, and the vacancy can easily activate O2 to replenish the consumed one.	Oxygen	53-55	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
31312229-6	2019	O2 consumption and CO2 production were higher in Ccr7 null mice than in wild-type mice, despite a similar respiratory quotient and glucose and lipid utilization, suggesting that energy expenditure increased in Ccr7 null mice via enhanced metabolism.	Oxygen	0-2	chemokine (C-C motif) receptor 7	Mus musculus	210-214
31312229-6	2019	O2 consumption and CO2 production were higher in Ccr7 null mice than in wild-type mice, despite a similar respiratory quotient and glucose and lipid utilization, suggesting that energy expenditure increased in Ccr7 null mice via enhanced metabolism.	Oxygen	0-2	chemokine (C-C motif) receptor 7	Mus musculus	49-53
31264974-4	2019	Here, we identified a regulatory axis whereby the oxygen-sensing transcription factor HIF-1alpha orchestrated epithelial barrier integrity, selectively controlling tight junction CLDN1 (claudin-1).	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
30508396-5	2019	Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including beta-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-gammaH2A.X (phosphorylated gamma-histone family member X).	Oxygen	25-27	cyclin dependent kinase inhibitor 2A	Homo sapiens	168-171
31477256-1	2019	Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism.	Oxygen	26-32	erythropoietin	Homo sapiens	153-167
30863976-0	2019	The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension.	Oxygen	83-89	superoxide dismutase 1	Homo sapiens	30-52
30863976-11	2019	Our results show for the first time that O2 tension is a principal determinant of SOD1 stability in human patient-derived cells.	Oxygen	41-43	superoxide dismutase 1	Homo sapiens	82-86
30860893-2	2019	Catalase-containing silica nanoshells are nanoparticles that generate O2 microbubbles imaged with ultrasound in the presence of elevated H2O2.	Oxygen	70-72	catalase	Homo sapiens	0-8
30860893-3	2019	We aimed to determine whether ultrasound-detectable O2 microbubbles produced by catalase-containing silica nanoshells can determine whether fluid collections drained from patients are infected.	Oxygen	52-54	catalase	Homo sapiens	80-88
30995110-7	2019	Consistent with in vivo results, inhibition of ADK suppressed cisplatin-induced apoptosis, reactive oxygen species production, and inflammation in HK2 cells.	Oxygen	100-106	adenosine kinase	Homo sapiens	47-50
30508396-5	2019	Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including beta-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-gammaH2A.X (phosphorylated gamma-histone family member X).	Oxygen	25-27	tumor protein p53	Homo sapiens	184-187
31035003-0	2019	Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy.	Oxygen	88-94	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
31038790-1	2019	In secondary erythrocytosis, the elevated red cell count is powered by factors outside the erythroid compartment, for instance by raised erythropoietin (EPO) synthesis based on congenital defects of the oxygen-sensing pathway.	Oxygen	203-209	erythropoietin	Homo sapiens	137-151
31038790-1	2019	In secondary erythrocytosis, the elevated red cell count is powered by factors outside the erythroid compartment, for instance by raised erythropoietin (EPO) synthesis based on congenital defects of the oxygen-sensing pathway.	Oxygen	203-209	erythropoietin	Homo sapiens	153-156
30970221-3	2019	The mesenchymal stem cells (MSCs) were harvested from male rats and cytoprotective effect of this designer SAP (DSAP) on cultured MSCs was detected by Hoechst 33342 staining after being exposed to oxygen and glucose deprivation (OGD).	Oxygen	197-203	amyloid P component, serum	Rattus norvegicus	107-110
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	nitric oxide synthase 2, inducible	Mus musculus	252-256
31067085-11	2019	This work provides novel and relevant information about the signaling pathway of NFAT5 during responses to oxygen depletion in mammalian cells and suggests that the expression of iNOS induced by hypoxia is dependent on NFAT5.	Oxygen	107-113	nitric oxide synthase 2	Homo sapiens	179-183
31593847-9	2019	MiR-182 mimic was administered before oxygen and glucose deprivation and reperfusion (OGD/R) in mice intestinal mucosa epithelial (MIME) cells.	Oxygen	38-44	microRNA 182	Mus musculus	0-7
30395227-2	2019	To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable form of HIF-1alpha can be inducibly expressed in cardiac myocytes, under the regulation of tetracycline.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-14
30395227-8	2019	In HEK293 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1, we demonstrated inhibition of HIF-1 activity by a luciferase reporter assay.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
30395227-8	2019	In HEK293 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1, we demonstrated inhibition of HIF-1 activity by a luciferase reporter assay.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-52
30395227-9	2019	Using mouse primary cells and cell lines, we show that transfection with oxygen-stable HIF-1alpha and PRKCBP1 reduced expression of direct HIF-1 gene targets and that knockdown of PRKCBP1 removes that negative inhibition.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
30395227-10	2019	Consistent with previous reports suggesting that PRKCBP1 modulates the chromatin landscape, we found that HL-1 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1 have reduced global 5-methyl cytosine compared to HIF-1 alone.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-153
30679163-11	2019	Furthermore, LIMS1 promoted HIF1A protein translation by activating AKT/mTOR signaling, while hypoxia-inducible factor 1 (HIF1) transactivated LIMS1 transcription, thus forming a positive feedback loop in PDAC cell adaptation to oxygen deprivation stress.	Oxygen	229-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-120
31023420-6	2019	The line with the lowest ANS expression level, ans-1, was also the most sensitive to HL, showing the lowest anthocyanin content, chlorophyll content, Fv/Fm ratio, and Rubisco content and the highest O2 - accumulation and membrane leakage rate, although it also had the highest antioxidant capacity.	Oxygen	199-201	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	47-50
31059007-9	2019	In vitro, protein expression of p57KIP2 was increased in HTR-8/SVneo cells exposed to 2% O2.	Oxygen	89-91	cyclin dependent kinase inhibitor 1C	Homo sapiens	32-39
31022415-7	2019	In contrast, high HNF-1beta expression was significantly associated with SLC3A1 expression, which plays a major role in HNF-1beta-triggered induction of reactive oxygen species in OCCCas, independent of abnormalities in both beta-catenin and MSI/MMR status.	Oxygen	162-168	HNF1 homeobox A	Homo sapiens	18-27
31022415-7	2019	In contrast, high HNF-1beta expression was significantly associated with SLC3A1 expression, which plays a major role in HNF-1beta-triggered induction of reactive oxygen species in OCCCas, independent of abnormalities in both beta-catenin and MSI/MMR status.	Oxygen	162-168	HNF1 homeobox A	Homo sapiens	120-129
31059007-12	2019	Taken together, p57KIP2 knockdown significantly increased apoptosis in HTR-8/SVneo cells exposed to 2% O2, whereas overexpression of p57KIP2 had opposite effects, mediated by the JNK/stress activated protein kinase (SAPK) signaling pathway.	Oxygen	103-105	cyclin dependent kinase inhibitor 1C	Homo sapiens	16-23
31335953-0	2019	Age-Related Decline of Retinal Oxygen Extraction in Healthy Subjects.	Oxygen	31-37	renin binding protein	Homo sapiens	0-3
31335953-1	2019	Purpose: To investigate the age-dependence of total retinal blood flow and total retinal oxygen extraction in healthy subjects and determine their possible correlations with structural optical coherence tomography (OCT) parameters.	Oxygen	89-95	renin binding protein	Homo sapiens	28-31
31335953-10	2019	Conclusions: We showed that there was an age-related decline of retinal oxygen extraction.	Oxygen	72-78	renin binding protein	Homo sapiens	41-44
31379413-6	2019	In females only, VEGF level was negatively correlated with O2  - scavenging activity before the astaxanthin intake (r = -0.6, p&lt;0.01) and positively correlated with total hydroperoxide level before and after the astaxanthin intake (r = 0.7 and 0.8, respectively, p&lt;0.01).	Oxygen	59-61	vascular endothelial growth factor A	Homo sapiens	17-21
31375326-0	2019	Transplantation of cardiac Sca-1-positive cells rather than c-Kit-positive cells preserves mitochondrial oxygen consumption of the viable myocardium following myocardial infarction in rats.	Oxygen	105-111	ataxin 1	Rattus norvegicus	27-32
31263281-7	2019	Subsequent therapy of the lead proband with a MEK inhibitor led to dramatic clinical improvement, with remodeling of the patient"s lymphatic system with resolution of the lymphatic edema, marked improvement in his pulmonary function tests, cessation of supplemental oxygen requirements and near normalization of daily activities.	Oxygen	266-272	mitogen-activated protein kinase kinase 7	Homo sapiens	46-49
31012816-14	2019	Conclusion MRI-based brain oxygen extraction shows that cognitively healthy carriers of the apolipoprotein E4 gene manifest diminished brain oxygen extraction capacity independent of amyloid burden.	Oxygen	27-33	apolipoprotein E	Homo sapiens	92-109
30999001-8	2019	Therefore, the inhibition of cytochrome c oxidase by  NO may be involved in the physiological and/or pathological regulation of respiration rate, and its affinity for oxygen, which depend on reactive nitrogen species formation, pH, proton motriz force and oxygen supply to tissues.	Oxygen	167-173	cytochrome c, somatic	Homo sapiens	29-41
30999001-8	2019	Therefore, the inhibition of cytochrome c oxidase by  NO may be involved in the physiological and/or pathological regulation of respiration rate, and its affinity for oxygen, which depend on reactive nitrogen species formation, pH, proton motriz force and oxygen supply to tissues.	Oxygen	256-262	cytochrome c, somatic	Homo sapiens	29-41
31288900-0	2019	Early treatment of recombinant Akt protects the retina from oxygen-induced injury in mice.	Oxygen	60-66	thymoma viral proto-oncogene 1	Mus musculus	31-34
31288900-5	2019	These results indicate that Akt plays a critical role in the pathological process (vessels loss and neovascularization) of oxygen-induced retinopathy in a mouse model, which may provide a valuable therapeutic tool for ischemic-induced retinal diseases.	Oxygen	123-129	thymoma viral proto-oncogene 1	Mus musculus	28-31
31012816-0	2019	Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.	Oxygen	6-12	apolipoprotein E	Homo sapiens	75-91
31012816-3	2019	Purpose To investigate the influence of APOE4 on global cerebral oxygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brain oxygen extraction technique.	Oxygen	65-71	apolipoprotein E	Homo sapiens	40-45
31012816-14	2019	Conclusion MRI-based brain oxygen extraction shows that cognitively healthy carriers of the apolipoprotein E4 gene manifest diminished brain oxygen extraction capacity independent of amyloid burden.	Oxygen	141-147	apolipoprotein E	Homo sapiens	92-109
30882866-0	2019	STOP1 regulates the expression of HsfA2 and GDHs that are critical for low-oxygen tolerance in Arabidopsis.	Oxygen	75-81	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	0-5
30882866-0	2019	STOP1 regulates the expression of HsfA2 and GDHs that are critical for low-oxygen tolerance in Arabidopsis.	Oxygen	75-81	heat shock transcription factor A2	Arabidopsis thaliana	34-39
30882866-2	2019	In this study, we investigated the mechanism responsible for the sensitivity of the stop1 mutant to low-oxygen stress in Arabidopsis.	Oxygen	104-110	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	84-89
31117657-3	2019	A recent study of FtmOx1, a fungal iron(II)- and 2-(oxo)glutarate-dependent oxygenase that installs the endoperoxide of verruculogen by adding O2 between carbons 21 and 27 of fumitremorgin B, posited that tyrosine (Tyr or Y) 224 serves as HAT intermediary to separate the C21 radical (C21 ) and Fe(III)-OH HAT products and prevent rebound.	Oxygen	143-145	TBL1X/Y related 1	Homo sapiens	272-275
30882866-3	2019	Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type.	Oxygen	64-70	glutamate dehydrogenase 2	Arabidopsis thaliana	126-130
30882866-3	2019	Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type.	Oxygen	64-70	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	170-175
30882866-4	2019	Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the low-oxygen sensitivity of the stop1 mutant.	Oxygen	49-55	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	128-133
30882866-4	2019	Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the low-oxygen sensitivity of the stop1 mutant.	Oxygen	102-108	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	128-133
30882866-6	2019	An in planta complementation assay indicated that CaMV35S::STOP2 or CaMV35S::HsfA2 partially rescued the low-oxygen tolerance of the stop1 mutant, which was concomitant with recovered expression of genes regulating low-pH tolerance and genes encoding molecular chaperones.	Oxygen	109-115	heat shock transcription factor A2	Arabidopsis thaliana	77-82
30882866-6	2019	An in planta complementation assay indicated that CaMV35S::STOP2 or CaMV35S::HsfA2 partially rescued the low-oxygen tolerance of the stop1 mutant, which was concomitant with recovered expression of genes regulating low-pH tolerance and genes encoding molecular chaperones.	Oxygen	109-115	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	133-138
31117657-3	2019	A recent study of FtmOx1, a fungal iron(II)- and 2-(oxo)glutarate-dependent oxygenase that installs the endoperoxide of verruculogen by adding O2 between carbons 21 and 27 of fumitremorgin B, posited that tyrosine (Tyr or Y) 224 serves as HAT intermediary to separate the C21 radical (C21 ) and Fe(III)-OH HAT products and prevent rebound.	Oxygen	143-145	TBL1X/Y related 1	Homo sapiens	285-288
30994642-2	2019	Here, an oxygen self-supplied nanodelivery system that is based on nanometal-organic frameworks (nMOFs) with embedded AuNPs (Au@ZIF-8) on the nMOF surface as a catalase (CAT)-like nanozyme and encapsulating Ce6 inside as a photosensitizer was found to mitigate tumor hypoxia and reinforce PDT.	Oxygen	9-15	catalase	Homo sapiens	160-168
31117657-5	2019	The C21-hydroxylated (rebound) product, which undergoes deprenylation, predominates when low [O2] slows C21 -O2 coupling in the next step of the endoperoxidation pathway.	Oxygen	94-96	TBL1X/Y related 1	Homo sapiens	4-7
30994642-2	2019	Here, an oxygen self-supplied nanodelivery system that is based on nanometal-organic frameworks (nMOFs) with embedded AuNPs (Au@ZIF-8) on the nMOF surface as a catalase (CAT)-like nanozyme and encapsulating Ce6 inside as a photosensitizer was found to mitigate tumor hypoxia and reinforce PDT.	Oxygen	9-15	catalase	Homo sapiens	170-173
31117657-5	2019	The C21-hydroxylated (rebound) product, which undergoes deprenylation, predominates when low [O2] slows C21 -O2 coupling in the next step of the endoperoxidation pathway.	Oxygen	94-96	TBL1X/Y related 1	Homo sapiens	104-107
31098605-3	2019	Removal of Cu(ii) from the amyloid-beta peptide prevents the stabilization of oligomers and protofibrils and the complexation of Cu(i) also stops the formation of reactive oxygen species.	Oxygen	172-178	amyloid beta precursor protein	Homo sapiens	27-39
31143894-1	2019	Treating iminoxyl species with oxygen acceptors such as PPh3 resulted in oxygen atom transfer and afforded the corresponding iminyl radicals.	Oxygen	31-37	caveolin 1	Homo sapiens	56-60
31143894-1	2019	Treating iminoxyl species with oxygen acceptors such as PPh3 resulted in oxygen atom transfer and afforded the corresponding iminyl radicals.	Oxygen	73-79	caveolin 1	Homo sapiens	56-60
31212255-1	2019	We have shown that the effects of transplantation of CD146+ mesenchymal stem cells (MSCs) on myocardial regeneration after myocardial infarction (MI) exceeds the effects of transplantation of MSCs, likely resulting from reduction of aging-associated cellular reactive oxygen species in injured cardiac muscle cells (CMCs).	Oxygen	268-274	melanoma cell adhesion molecule	Mus musculus	53-58
30953923-1	2019	High oxygen sensitivity (the slope of the Stern-Volmer plot reaches 0.73/muM) is achieved with a phosphorescence indicator, gadolinium-hematoporphyrin monomethyl ether (Gd-HMME), by decreasing the extent of its protection.	Oxygen	5-11	latexin	Homo sapiens	73-76
30953923-6	2019	The oxygen response of Gd-HMME without any protection reaches 240 (0-374 muM oxygen), whereas that in the rigid microenvironment is only 3 in this range.	Oxygen	4-10	latexin	Homo sapiens	73-76
31003769-0	2019	MicroRNA-146b-5p protects oligodendrocyte precursor cells from oxygen/glucose deprivation-induced injury through regulating Keap1/Nrf2 signaling via targeting bromodomain-containing protein 4.	Oxygen	63-69	kelch like ECH associated protein 1	Homo sapiens	124-129
30953923-9	2019	Gd-HMME without any protection can be applied to detect oxygen as low as 0.1 muM.	Oxygen	56-62	latexin	Homo sapiens	77-80
31245372-2	2019	EPO production by the neural crest is transient in mid-stage embryos but essential for the first erythropoiesis in the yolk sac and for sufficient oxygen supply in the whole embryo growing in utero.	Oxygen	147-153	erythropoietin	Homo sapiens	0-3
31003769-0	2019	MicroRNA-146b-5p protects oligodendrocyte precursor cells from oxygen/glucose deprivation-induced injury through regulating Keap1/Nrf2 signaling via targeting bromodomain-containing protein 4.	Oxygen	63-69	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
31003769-0	2019	MicroRNA-146b-5p protects oligodendrocyte precursor cells from oxygen/glucose deprivation-induced injury through regulating Keap1/Nrf2 signaling via targeting bromodomain-containing protein 4.	Oxygen	63-69	bromodomain containing 4	Homo sapiens	159-191
31003769-4	2019	In this study, we aimed to investigate the potential function of miR-146b-45p in regulating oxygen/glucose deprivation (OGD)-induced injury of OPCs and explore the underlying mechanism.	Oxygen	92-98	microRNA 146b	Homo sapiens	65-73
31206022-4	2019	Disruption of the BAP31-Tom40 complex inhibits mitochondrial complex I activity and oxygen consumption by the decreased NDUFS4 localization to the mitochondria.	Oxygen	84-90	translocase of outer mitochondrial membrane 40	Homo sapiens	24-29
31171849-5	2019	In contrast, the constitutive growth phenotypes are invariant within this range of molecular oxygen suggesting that ESR1 mutations confer a growth advantage not only during estrogen deprivation but also at lower oxygen levels.	Oxygen	93-99	estrogen receptor 1	Homo sapiens	116-120
31333799-9	2019	PGC1alpha expression correlated with oxygen consumption in thyroid cancer cells and was inversely related to AKT activity.	Oxygen	37-43	PPARG coactivator 1 alpha	Homo sapiens	0-9
31211019-6	2019	Deoxygenated haemoglobin ( HHb) in the pre-frontal cortex (FH), gastrocnemius (GN), left vastus lateralis (LVL) and the right vastus lateralis (RVL) muscles, systemic oxygen utilisation (VO2), systolic (SBP) and diastolic (DBP) blood pressure and physical activity enjoyment scale (PACES) were measured during the experiment conditions.	Oxygen	2-8	D-box binding PAR bZIP transcription factor	Homo sapiens	223-226
31171849-5	2019	In contrast, the constitutive growth phenotypes are invariant within this range of molecular oxygen suggesting that ESR1 mutations confer a growth advantage not only during estrogen deprivation but also at lower oxygen levels.	Oxygen	212-218	estrogen receptor 1	Homo sapiens	116-120
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
30950157-1	2019	In this study, we report a remarkably active CeVO4 nanozyme that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four-electron reduction of dioxygen to water.	Oxygen	221-229	cytochrome c, somatic	Homo sapiens	85-97
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-149
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	8-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	8-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-149
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	197-199	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
31105007-1	2019	Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia).	Oxygen	197-199	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-149
30925081-2	2019	TNFalpha activates NADPH oxidase 1 (Nox1) and reactive oxygen species (ROS), including superoxide (O2 -), production extracellularly is required for subsequent signaling in vascular smooth muscle cells (VSMCs).	Oxygen	99-103	tumor necrosis factor	Homo sapiens	0-8
31169018-9	2019	Exposure of A549 cells to 1% O2 significantly up-regulated HIF1alpha expression, maintained cell viability to cisplatin but decreased the ROS level, which promoted chemoresistance to cisplatin.	Oxygen	29-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-68
30889497-3	2019	MDSP NPs (~54 nm), with near infrared absorption (~853 nm), can be rapidly dissociated to generate oxygen in response to TME, whereby improving tumor hypoxia, in favor of effective drugs release and enhanced chemo/photodynamic therapy.	Oxygen	99-105	dual specificity phosphatase 13	Homo sapiens	0-4
30552708-2	2019	This study aimed to reveal the functional impacts and the underlying mechanisms of NG-R1 on oxygen-glucose deprivation (OGD)-injured cardiomyocytes.	Oxygen	92-98	reticulon 4 receptor	Rattus norvegicus	83-88
30762162-1	2019	Cancer cells are characterized by a metabolic shift in cellular energy production, orchestrated by the transcription factor HIF-1alpha, from mitochondrial oxidative phosphorylation to increased glycolysis, regardless of oxygen availability (Warburg effect).	Oxygen	220-226	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
31934025-10	2019	Activity of intracellular reactive oxygen species was estimated by measuring the levels of superoxide dismutase (SOD), glutathione (GHS), and reactive oxygen species (ROS).	Oxygen	35-41	superoxide dismutase 1	Homo sapiens	91-111
31934025-10	2019	Activity of intracellular reactive oxygen species was estimated by measuring the levels of superoxide dismutase (SOD), glutathione (GHS), and reactive oxygen species (ROS).	Oxygen	35-41	superoxide dismutase 1	Homo sapiens	113-116
29355388-15	2019	Changes in capillary density and expression of VEGFA found in the p. major muscle of broilers with DPM suggest increased blood flow to increase oxygen availability.	Oxygen	144-150	vascular endothelial growth factor A	Parus major	47-52
30988028-4	2019	The negative effect of AFP on mitochondrial metabolism and ATP production was confirmed with observation of reduction in basal oxygen consumption rate (OCR) in DCs exposed to AFP derived from cord blood.	Oxygen	127-133	alpha fetoprotein	Homo sapiens	23-26
30988028-4	2019	The negative effect of AFP on mitochondrial metabolism and ATP production was confirmed with observation of reduction in basal oxygen consumption rate (OCR) in DCs exposed to AFP derived from cord blood.	Oxygen	127-133	alpha fetoprotein	Homo sapiens	175-178
31111477-4	2019	Interestingly, CYP5A1 was found for the first time to work on a substrate other than prostaglandin H2 , and, moreover, to catalyze an aliphatic hydroxylation reaction that consumes molecular oxygen.	Oxygen	191-197	thromboxane A synthase 1	Homo sapiens	15-21
30949956-13	2019	These findings suggest that miR-181a protects neurons from apoptosis by inhibiting reelin expression and regulating the Smac/IAP signaling pathway after oxygen-glucose deprivation/reperfusion injury.	Oxygen	153-159	diablo, IAP-binding mitochondrial protein	Mus musculus	120-124
31033195-7	2019	We found that bromide decreased FFA-induced lipid accumulation and increased FFA-inhibited oxygen consumptions in mouse PHs in a dose-dependent manner via activation of PPARalpha.	Oxygen	91-97	peroxisome proliferator activated receptor alpha	Mus musculus	169-178
31022673-4	2019	In contrast, MEFs cultured at physiologically relevant conditions of 5% O2 exhibited a transient induction of Nrf2 Phase II target genes and stress-protective enzymes (the Lon protease and OXR1) following H2O2 treatment.	Oxygen	72-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
30940686-4	2019	Consistent with a role in PTI, bsk5 mutant plants displayed enhanced susceptibility to the bacterial pathogen Pseudomonas syringae and to the fungus Botrytis cinerea Furthermore, bsk5 mutant plants were impaired in several immune responses induced by the elf18, pep1, and flg22 PAMP/DAMPs, including resistance to P. syringae and B. cinerea, production of reactive oxygen species, callose deposition at the cell wall, and enhanced PATHOGENESIS-RELATED1 gene expression.	Oxygen	365-371	kinase with tetratricopeptide repeat domain-containing protein	Arabidopsis thaliana	31-35
30940686-4	2019	Consistent with a role in PTI, bsk5 mutant plants displayed enhanced susceptibility to the bacterial pathogen Pseudomonas syringae and to the fungus Botrytis cinerea Furthermore, bsk5 mutant plants were impaired in several immune responses induced by the elf18, pep1, and flg22 PAMP/DAMPs, including resistance to P. syringae and B. cinerea, production of reactive oxygen species, callose deposition at the cell wall, and enhanced PATHOGENESIS-RELATED1 gene expression.	Oxygen	365-371	kinase with tetratricopeptide repeat domain-containing protein	Arabidopsis thaliana	179-183
31108461-13	2019	Our data highlight a hitherto unrecognized role of macrophage-hepatocyte crosstalk for a joint and oxygen-dependent hepcidin production through STAT3 and CEBPdelta.	Oxygen	99-105	signal transducer and activator of transcription 3	Homo sapiens	144-149
31137604-5	2019	Human dermal fibroblasts cultured under hypoxia (1% O2) expressed phosphorylated ERK and exhibited activation of p38 mitogen-activated protein kinase signaling.	Oxygen	52-54	mitogen-activated protein kinase 1	Homo sapiens	81-84
30876885-1	2019	Cellular adaptation to hypoxia is controlled by hypoxia-inducible factor 1alpha (HIF1alpha), a transcription factor activated in response to oxygen tension, reactive oxygen species (ROS) and inflammation.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-79
30876885-1	2019	Cellular adaptation to hypoxia is controlled by hypoxia-inducible factor 1alpha (HIF1alpha), a transcription factor activated in response to oxygen tension, reactive oxygen species (ROS) and inflammation.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-90
30928399-7	2019	The results show that overexpression of KLF2 increased the cell viability, reduced the lactate dehydrogenase leakage rate, downregulated the generation of O2 - and ONOO-, and increased NO levels and eNOS activity.	Oxygen	155-157	Kruppel like factor 2	Homo sapiens	40-44
30768269-5	2019	The kinetics of N-NO2 and C-N bond cleavage, as well as the following oxygen-abstraction of NO2, are significantly slowed in the CL-20/TNT thermolysis against beta-CL-20, which are responsible for the low sensitivity at the stage of active intermediate generation.	Oxygen	70-76	epithelial membrane protein 1	Homo sapiens	129-134
30768269-5	2019	The kinetics of N-NO2 and C-N bond cleavage, as well as the following oxygen-abstraction of NO2, are significantly slowed in the CL-20/TNT thermolysis against beta-CL-20, which are responsible for the low sensitivity at the stage of active intermediate generation.	Oxygen	70-76	epithelial membrane protein 1	Homo sapiens	164-169
31070624-5	2019	The controlled reaction time within the ion mobility instrument enables calculation of ozonation reaction rates and assuming oxygen atoms are added sequentially, we find that the reaction rate between C60- and O3 is near the collision controlled limit.	Oxygen	125-131	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	201-212
31137604-5	2019	Human dermal fibroblasts cultured under hypoxia (1% O2) expressed phosphorylated ERK and exhibited activation of p38 mitogen-activated protein kinase signaling.	Oxygen	52-54	mitogen-activated protein kinase 14	Homo sapiens	113-149
31113906-11	2019	Our results show that a) oxygen and the targets of SV40LT (e.g. p53) modulate epigenetic aging rates and b) the chronological age of donor cells determines the speed of mitosis-associated DNAm age progression in daughter cells.	Oxygen	25-31	tumor protein p53	Homo sapiens	64-67
31240212-0	2019	Role of TGF-Beta1/SMAD2/3 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 50/10 Oxygen-Induced Retinopathy.	Oxygen	110-116	transforming growth factor, beta 1	Rattus norvegicus	8-17
31240212-4	2019	We hypothesized that the TGF-beta1 alteration in rat 50/10 oxygen-induced retinopathy (OIR) model contributed to oDVP malformation and exerted consequent effects on photoreceptor development.	Oxygen	59-65	transforming growth factor, beta 1	Rattus norvegicus	25-34
31231213-5	2019	Here, we found that APN and APN receptor agonist AdipoRon (APR) were protective against excitotoxicity induced by oxygen and glucose deprivation/reperfusion (OGD/R) and NMDA in primary neurons.	Oxygen	114-120	adiponectin, C1Q and collagen domain containing	Homo sapiens	20-23
31231213-5	2019	Here, we found that APN and APN receptor agonist AdipoRon (APR) were protective against excitotoxicity induced by oxygen and glucose deprivation/reperfusion (OGD/R) and NMDA in primary neurons.	Oxygen	114-120	adiponectin, C1Q and collagen domain containing	Homo sapiens	28-31
30848866-2	2019	CoII sites associated with oxygen vacancies were favored at low temperatures and performed selective C-O hydrogenolysis, in which Sr-substitution facilitated oxygen vacancy formation, leading to approximately 10 times higher reactivity compared to undoped LaCoO3 .	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
30848866-2	2019	CoII sites associated with oxygen vacancies were favored at low temperatures and performed selective C-O hydrogenolysis, in which Sr-substitution facilitated oxygen vacancy formation, leading to approximately 10 times higher reactivity compared to undoped LaCoO3 .	Oxygen	158-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
30685435-7	2019	The effect was found to be dependent on oxygen availability, wherein DLBS6747-increased EPO expression was found to be more significant in hypoxic condition.	Oxygen	40-46	erythropoietin	Homo sapiens	88-91
32475850-2	2019	The plasma protein haptoglobin (Hp) takes care of the Hb physiologically leaked into the plasma - it binds Hb and makes it much less toxic while retaining the Hb"s high oxygen transporting capacity.	Oxygen	169-175	haptoglobin	Homo sapiens	19-30
31214621-2	2019	Hypoxia-inducible factor-1 (HIF-1) is the key mediator in cellular oxygen homeostasis that facilitates the adaptation to hypoxia.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
31214621-2	2019	Hypoxia-inducible factor-1 (HIF-1) is the key mediator in cellular oxygen homeostasis that facilitates the adaptation to hypoxia.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
31068630-0	2019	A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
30994634-6	2019	The competition between the reaction of CHF2O radicals with O2 and with CH2F2 was investigated and an experimental rate coefficient ratio of 0.57 +- 0.08 of reaction with O2 over reaction with CH2F2 was determined.	Oxygen	60-62	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	40-44
30994634-6	2019	The competition between the reaction of CHF2O radicals with O2 and with CH2F2 was investigated and an experimental rate coefficient ratio of 0.57 +- 0.08 of reaction with O2 over reaction with CH2F2 was determined.	Oxygen	171-173	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	40-44
31068630-4	2019	Herein we report a non-invasive in vitro detection method of hypoxia using designed fluorescent peptide probes based on the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	163-173
30779468-2	2019	Herein, the ability of sp2 carbonyl oxygen atoms to act as halogen-bond acceptors was established through cocrystallization.	Oxygen	36-42	Sp2 transcription factor	Homo sapiens	23-26
31068630-5	2019	The fluorescent probe retains the oxygen-sensing capability of HIF-1alpha, so that it is stabilized under hypoxia and readily degraded by the proteasome under normoxia, thus providing direct information of the cellular oxygen availability.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
31068630-5	2019	The fluorescent probe retains the oxygen-sensing capability of HIF-1alpha, so that it is stabilized under hypoxia and readily degraded by the proteasome under normoxia, thus providing direct information of the cellular oxygen availability.	Oxygen	219-225	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
30895741-3	2019	This result indicated that QQ-BF2 was first generated as an O,O-bidentate chelate, which immediately underwent a two-electron reduction to produce QA-BF2 .	Oxygen	60-63	forkhead box G1	Homo sapiens	30-33
31088512-3	2019	We investigated whether cerebral oxygen saturation (rSO2) measured with NIRS correlates with the serum concentration of neuron-specific enolase (NSE), a marker of neurological injury, and with clinical outcome in out-of-hospital cardiac arrest (OHCA) patients.	Oxygen	33-39	enolase 2	Homo sapiens	120-143
31088512-3	2019	We investigated whether cerebral oxygen saturation (rSO2) measured with NIRS correlates with the serum concentration of neuron-specific enolase (NSE), a marker of neurological injury, and with clinical outcome in out-of-hospital cardiac arrest (OHCA) patients.	Oxygen	33-39	enolase 2	Homo sapiens	145-148
30905713-11	2019	We found that H2O2 increases the toxicity of TDP-43, suggesting that the reactive oxygen species associated with respiration could likewise enhance the toxicity of TDP-43.	Oxygen	82-88	TAR DNA binding protein	Homo sapiens	45-51
30905713-11	2019	We found that H2O2 increases the toxicity of TDP-43, suggesting that the reactive oxygen species associated with respiration could likewise enhance the toxicity of TDP-43.	Oxygen	82-88	TAR DNA binding protein	Homo sapiens	164-170
30905713-12	2019	In this case, the TDP-43 toxicity targets in the presence or absence of respiration could be identical, with the reactive oxygen species produced by respiration activating TDP-43 to become more toxic or making TDP-43 targets more vulnerable.	Oxygen	122-128	TAR DNA binding protein	Homo sapiens	172-178
30905713-12	2019	In this case, the TDP-43 toxicity targets in the presence or absence of respiration could be identical, with the reactive oxygen species produced by respiration activating TDP-43 to become more toxic or making TDP-43 targets more vulnerable.	Oxygen	122-128	TAR DNA binding protein	Homo sapiens	172-178
30895741-3	2019	This result indicated that QQ-BF2 was first generated as an O,O-bidentate chelate, which immediately underwent a two-electron reduction to produce QA-BF2 .	Oxygen	60-63	forkhead box G1	Homo sapiens	150-153
30860876-0	2019	Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production.	Oxygen	138-144	insulin	Homo sapiens	21-28
30690774-2	2019	Changes in Hb oxygen affinity shift the oxygen dissociation curve, and can be identified by abnormal p50 measurements of patient red blood cells.	Oxygen	14-20	nuclear factor kappa B subunit 1	Homo sapiens	101-104
29099662-3	2019	We determined the cerebral metabolic rate of oxygen (CMRO2) along a tissue depth of &lt;0.3 mm in the hippocampal CA3 region during various network activities, including gamma oscillations and sharp wave-ripples that occur during wakefulness and sleep.	Oxygen	45-51	carbonic anhydrase 3	Mus musculus	114-117
30607695-8	2019	Furthermore, in an oxygen-induced retinopathy model, overexpression of KLF4 results in decreased vaso-obliteration and neovascular tuft formation that is similar to genetic or pharmacologic DLL4 inhibition.	Oxygen	19-25	Kruppel-like factor 4 (gut)	Mus musculus	71-75
30719713-1	2019	EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity.	Oxygen	103-109	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-5
30719713-1	2019	EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity.	Oxygen	103-109	egl-9 family hypoxia inducible factor 1	Homo sapiens	57-77
30719713-1	2019	EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity.	Oxygen	103-109	egl-9 family hypoxia inducible factor 1	Homo sapiens	79-83
30856427-0	2019	Oxygen-reducing microbial cathodes monitoring toxic shocks in tap water.	Oxygen	0-6	USO1 vesicle transport factor	Homo sapiens	62-65
30856427-6	2019	Here we show that O2-reducing EABs can grow in unamended tap water on carbon electrodes at + 0.2 V vs. Ag/AgCl.	Oxygen	18-20	USO1 vesicle transport factor	Homo sapiens	57-60
30948460-7	2019	This multi-tier regulation coordinated by ADAR1 promotes robust and timely accumulation of HIF-1alpha upon oxygen depletion and reinforces target gene induction and downstream angiogenesis.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
30776354-4	2019	In the present study, we used a gene microarray and western blotting analysis to show that the expression of mitochondrially encoded cytochrome c oxidase subunit 2 (MT-CO2, COXII) increased significantly in SH-SY5Y cells stimulated by alpha-Syn for 24 h. Furthermore, the decline in ATP levels, the decreased mitochondrial membrane potential, and the enhanced reactive oxygen species in cells treated by alpha-Syn was reversed by inhibiting MT-CO2 gene expression.	Oxygen	369-375	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
30849487-2	2019	Most of previous studies reported that Cu-Abeta could contribute to oxidative stress, as H2O2 and  OH are catalytically generated by Cu-Abeta with the assistance of biological reductant, with only one recent report stated that free O2 - is also generated in the Cu-Abeta catalyzed processes, where an indirect technique was applied.	Oxygen	232-236	amyloid beta precursor protein	Homo sapiens	42-47
30849487-4	2019	All the experimental results obtained from the three methods demonstrated that Cu-Abeta in the biological reducing environment was not only able to catalyze the production of H2O2 and  OH, but also to generate free O2 -.	Oxygen	215-219	amyloid beta precursor protein	Homo sapiens	82-87
30849487-8	2019	More interestingly, the fibrillar forms of Abeta generated less O2 - and  OH compared with oligomeric and monomeric forms.	Oxygen	64-68	amyloid beta precursor protein	Homo sapiens	43-48
30820661-5	2019	The rate of oxygen desaturation during the first 3 min of exercise was accelerated in severe hypoxia (- 5.3 +- 2.8% min- 1) relative to moderate hypoxia (- 2.5 +- 1.0% min- 1) and normoxia (- 0.7 +- 0.3% min- 1).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
30820661-5	2019	The rate of oxygen desaturation during the first 3 min of exercise was accelerated in severe hypoxia (- 5.3 +- 2.8% min- 1) relative to moderate hypoxia (- 2.5 +- 1.0% min- 1) and normoxia (- 0.7 +- 0.3% min- 1).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	168-174
30820661-5	2019	The rate of oxygen desaturation during the first 3 min of exercise was accelerated in severe hypoxia (- 5.3 +- 2.8% min- 1) relative to moderate hypoxia (- 2.5 +- 1.0% min- 1) and normoxia (- 0.7 +- 0.3% min- 1).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	168-174
30776180-9	2019	The addition of naringenin significantly and dose-dependently increased the respiratory rate from 5.8 +- 0.2 to 14.0 +- 0.6 nmol O2  x min-1  x mg protein-1 .	Oxygen	129-131	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
31397596-0	2019	Hb Alcorn County: A beta-Globin Variant [beta40(C6)Arg Thr; HBB: c.122G&gt;C (p.Arg41Thr)] with Increased Oxygen Affinity.	Oxygen	106-112	amyloid beta precursor protein	Homo sapiens	18-24
31082959-0	2019	Mechanism of Emulsified Isoflurane Postconditioning-Induced Activation of the Nrf2-Antioxidant Response Element Signaling Pathway During Myocardial Ischemia-Reperfusion: The Relationship With Reactive Oxygen Species.	Oxygen	201-207	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
30814312-11	2019	In this manuscript, we show that, while loss of Ucp2 does increase mitochondrial membrane potential and the production of reactive oxygen species, it also initiates an increase in mitophagy that is ultimately neuroprotective.	Oxygen	131-137	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	48-52
31085953-1	2019	The mechanistic target of rapamycin (mTOR) pathway coordinates the metabolic activity of eukaryotic cells through environmental signals, including nutrients, energy, growth factors, and oxygen.	Oxygen	186-192	mechanistic target of rapamycin kinase	Homo sapiens	4-35
31085953-1	2019	The mechanistic target of rapamycin (mTOR) pathway coordinates the metabolic activity of eukaryotic cells through environmental signals, including nutrients, energy, growth factors, and oxygen.	Oxygen	186-192	mechanistic target of rapamycin kinase	Homo sapiens	37-41
30601794-0	2019	A Simple Method to Quantify the V O2 Mean Response Time of Ramp-Incremental Exercise.	Oxygen	34-36	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	59-63
30601794-1	2019	During ramp-incremental exercise, the mean response time (MRT) of oxygen uptake (V O2) represents the time delay for changes in muscle V O2 to be reflected at the level of the mouth and is generally calculated by linear (MRTLIN) and monoexponential (tau") fitting of V O2 data.	Oxygen	66-72	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	7-11
30601794-1	2019	During ramp-incremental exercise, the mean response time (MRT) of oxygen uptake (V O2) represents the time delay for changes in muscle V O2 to be reflected at the level of the mouth and is generally calculated by linear (MRTLIN) and monoexponential (tau") fitting of V O2 data.	Oxygen	83-85	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	7-11
30601794-1	2019	During ramp-incremental exercise, the mean response time (MRT) of oxygen uptake (V O2) represents the time delay for changes in muscle V O2 to be reflected at the level of the mouth and is generally calculated by linear (MRTLIN) and monoexponential (tau") fitting of V O2 data.	Oxygen	137-139	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	7-11
30601794-1	2019	During ramp-incremental exercise, the mean response time (MRT) of oxygen uptake (V O2) represents the time delay for changes in muscle V O2 to be reflected at the level of the mouth and is generally calculated by linear (MRTLIN) and monoexponential (tau") fitting of V O2 data.	Oxygen	137-139	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	7-11
31118615-12	2019	Furthermore, MSN-trityl displayed outstanding intracellular oxygen mapping in both in vitro and in vivo animal studies.	Oxygen	60-66	moesin	Homo sapiens	13-16
30705246-3	2019	We have previously characterized HAF as an oxygen-independent ubiquitin ligase for HIF-1alpha.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
31009360-12	2019	By contrast, IPC induced SOCE and Ca2+ release-activated Ca2+current upregulation, thereby preventing STIM1 and ORAI1 downregulation induced by oxygen and glucose deprivation+reoxygenation.	Oxygen	144-150	stromal interaction molecule 1	Rattus norvegicus	102-107
30664690-3	2019	Isogenic p53-null radioresistant cancer cells established through cumulative irradiation showed decreased oxygen consumption and increased glycolysis with compromised mitochondria, corresponding with their enhanced sensitivity to drugs that target glycolysis.	Oxygen	106-112	tumor protein p53	Homo sapiens	9-12
30957431-2	2019	Herein, a Co-engineered FeOOH catalyst integrated on carbon fiber paper (Co-FeOOH/CFP) is reported, which realized a great improvement of the oxygen evolution activity by tuning the coordination geometry of the Fe species with an electrochemically driven method.	Oxygen	142-148	complement factor properdin	Homo sapiens	82-85
31052167-2	2019	In our research, a series of dihydropyrazole derivatives containing benzo oxygen heterocycle and sulfonamide moieties were designed as highly potent and selective COX-2 inhibitors by computer-aided drug analysis of known COX-2 inhibitors.	Oxygen	74-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	163-168
31052167-2	2019	In our research, a series of dihydropyrazole derivatives containing benzo oxygen heterocycle and sulfonamide moieties were designed as highly potent and selective COX-2 inhibitors by computer-aided drug analysis of known COX-2 inhibitors.	Oxygen	74-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	221-226
31293763-4	2019	Due to the high oxygen capacity of such nanoparticles, the hypoxic tumor microenvironment was greatly modulated after these nanoparticles reached the tumor region, and the results revealed that hypoxia-inducible factor alpha (HIF-1alpha) was down-regulated and the expression of P-glycoprotein (P-gp) was then reduced, which were in favor of chemotherapy.	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	226-236
31293763-4	2019	Due to the high oxygen capacity of such nanoparticles, the hypoxic tumor microenvironment was greatly modulated after these nanoparticles reached the tumor region, and the results revealed that hypoxia-inducible factor alpha (HIF-1alpha) was down-regulated and the expression of P-glycoprotein (P-gp) was then reduced, which were in favor of chemotherapy.	Oxygen	16-22	ATP binding cassette subfamily B member 1	Homo sapiens	279-293
31293763-4	2019	Due to the high oxygen capacity of such nanoparticles, the hypoxic tumor microenvironment was greatly modulated after these nanoparticles reached the tumor region, and the results revealed that hypoxia-inducible factor alpha (HIF-1alpha) was down-regulated and the expression of P-glycoprotein (P-gp) was then reduced, which were in favor of chemotherapy.	Oxygen	16-22	ATP binding cassette subfamily B member 1	Homo sapiens	295-299
31035575-9	2019	Serum levels of TNF alpha were significantly reduced after oxygen persufflation (p &lt; 0.05).	Oxygen	59-65	tumor necrosis factor	Homo sapiens	16-25
31035592-3	2019	LDHA has a higher affinity for pyruvate, preferentially converting pyruvate to lactate, and NADH to NAD+ in anaerobic conditions, whereas LDHB possess a higher affinity for lactate, preferentially converting lactate to pyruvate, and NAD+ to NADH, when oxygen is abundant.	Oxygen	252-258	lactate dehydrogenase A	Homo sapiens	0-4
30964974-8	2019	The encapsulated catalase was able to decompose the endogenous H2O2 to generate O2 in situ for relieving hypoxia in cells incubated under hypoxic conditions.	Oxygen	65-67	catalase	Homo sapiens	17-25
31183001-12	2019	The extract alone did not modify superoxide (O2 -) and nitric oxide (NO ) production in femoral arteries from control mice but significantly limited Ang II-induced O2 - production.	Oxygen	164-168	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	149-155
30860522-6	2019	GE11-PDA-Pt@USPIOs had high specificity for EGFR-positive tumor cells, could catalyze decomposition of H2O2 to oxygen and exhibited radio-chemo synergetic therapeutic effects under hypothermia conditions in vitro.	Oxygen	111-117	epidermal growth factor receptor	Homo sapiens	44-48
30872401-7	2019	Pretreatment with acitretin abolished activation of Fyn kinase and prevented an increase in reactive oxygen species caused by AbetaO binding to PrPC Besides blocking AbetaO binding and toxicity, acitretin also increased the nonamyloidogenic processing of APP.	Oxygen	101-107	prion protein	Homo sapiens	144-148
30668788-6	2019	In cells that underwent multiple rounds of H2O2 treatments, we identified a genetic alteration that resulted in improved H2O2 tolerance by amplification of the CTT1 gene that encodes cytosolic catalase T. Lastly, we showed that cells grown in the absence of oxygen have reduced levels of recombination.	Oxygen	258-264	catalase T	Saccharomyces cerevisiae S288C	160-164
30996134-0	2019	Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia.	Oxygen	7-13	angiomotin	Homo sapiens	31-41
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	70-76	angiomotin	Homo sapiens	106-110
30817904-3	2019	Prolyl-4-hydroxylase 2 (PHD2), one member of PHDs family, regulates the stability of the hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to oxygen availability.	Oxygen	150-156	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-22
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	115-121	angiomotin	Homo sapiens	106-110
30817904-3	2019	Prolyl-4-hydroxylase 2 (PHD2), one member of PHDs family, regulates the stability of the hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to oxygen availability.	Oxygen	150-156	egl-9 family hypoxia inducible factor 1	Homo sapiens	24-28
30817904-3	2019	Prolyl-4-hydroxylase 2 (PHD2), one member of PHDs family, regulates the stability of the hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to oxygen availability.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-121
30996134-10	2019	Our data reveal an oxygen- and TGF-beta-driven migratory function for AMOT in the human placenta, and implicate its deficiency in impaired trophoblast migration that plagues preeclampsia.	Oxygen	19-25	angiomotin	Homo sapiens	70-74
30817904-3	2019	Prolyl-4-hydroxylase 2 (PHD2), one member of PHDs family, regulates the stability of the hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to oxygen availability.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
30817904-4	2019	During hypoxia, the inhibition of PHD2 permits the accumulation of HIF-1alpha, allowing the cellular adaptation to oxygen limitation, causing activation of numerous genes, which enhances the angiogenesis, metastasis and invasiveness.	Oxygen	115-121	egl-9 family hypoxia inducible factor 1	Homo sapiens	34-38
30740789-1	2019	An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR).	Oxygen	268-274	carboxylesterase 2	Homo sapiens	3-6
30817904-4	2019	During hypoxia, the inhibition of PHD2 permits the accumulation of HIF-1alpha, allowing the cellular adaptation to oxygen limitation, causing activation of numerous genes, which enhances the angiogenesis, metastasis and invasiveness.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
30817904-5	2019	Accurate regulation of oxygen homeostasis is essential, and which implies PHD2 may have a regulatory role in the pathogenesis of cancer.	Oxygen	23-29	egl-9 family hypoxia inducible factor 1	Homo sapiens	74-78
30817904-7	2019	Despite their original role as the oxygen sensors of the cell and many of the its functions are clearly conveyed through the HIF system, PHD2 is currently known to display HIF-independent and hydroxylase-independent functions in cancer cells and stroma in the control of different cellular pathways.	Oxygen	35-41	egl-9 family hypoxia inducible factor 1	Homo sapiens	137-141
31040780-5	2019	We also found that hypoxia (2% O2) activated p38/mitogen-activated protein kinase (MAPK) signaling, and we identified p38/MAPK as an upstream regulator of MAP4 phosphorylation in endothelial cells.	Oxygen	31-33	mitogen-activated protein kinase 14	Homo sapiens	45-81
30594715-2	2019	The current study revealed that reduction of GO to r-GO (the reduced form) was coupled with a decrease of oxygen-containing groups (OCGs) under reductive potential, and the maximum adsorption capacity of GO for Pb(II) decreased from 931.66 to 714.78 mg g-1 after electrochemical reduction.	Oxygen	106-112	submaxillary gland androgen regulated protein 3B	Homo sapiens	211-217
31040780-5	2019	We also found that hypoxia (2% O2) activated p38/mitogen-activated protein kinase (MAPK) signaling, and we identified p38/MAPK as an upstream regulator of MAP4 phosphorylation in endothelial cells.	Oxygen	31-33	mitogen-activated protein kinase 14	Homo sapiens	83-87
31040780-5	2019	We also found that hypoxia (2% O2) activated p38/mitogen-activated protein kinase (MAPK) signaling, and we identified p38/MAPK as an upstream regulator of MAP4 phosphorylation in endothelial cells.	Oxygen	31-33	mitogen-activated protein kinase 14	Homo sapiens	45-48
30735958-8	2019	Specifically, 5 mg L-1 nZVI dosage moderately enhanced the intracellular O2- production (~150% of the control) after scavenging 2.0 mg L-1 DO, and the anammox activity recovered better than that of both 5 and 25 mg L-1 Fe(II) ions additions.	Oxygen	73-75	immunoglobulin kappa variable 1-16	Homo sapiens	19-22
30735958-8	2019	Specifically, 5 mg L-1 nZVI dosage moderately enhanced the intracellular O2- production (~150% of the control) after scavenging 2.0 mg L-1 DO, and the anammox activity recovered better than that of both 5 and 25 mg L-1 Fe(II) ions additions.	Oxygen	73-75	immunoglobulin kappa variable 1-16	Homo sapiens	135-138
30735958-8	2019	Specifically, 5 mg L-1 nZVI dosage moderately enhanced the intracellular O2- production (~150% of the control) after scavenging 2.0 mg L-1 DO, and the anammox activity recovered better than that of both 5 and 25 mg L-1 Fe(II) ions additions.	Oxygen	73-75	immunoglobulin kappa variable 1-16	Homo sapiens	135-138
30955284-10	2019	VEGF concentration was correlated negatively with the lowest SpO(2) (r (s)=-0.480,P=0.001), but positively with apnea-hypopnea index(r (s)=0.403, P=0.005), oxygen desaturation index (r (s)=0.378, P=0.010) and proportion of SpO(2) less than or equal to 90% of total sleep time(r (s)=0.547, P=0.000 3).	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	0-4
30888785-2	2019	Relying on the catalytic generation of oxygen gas by catalase in H2O2 fuel, the jellyfish-like micromotor showed good bubble-propelled motion in different biomedia with speed exceeding 209 mum s-1 in 1.5% H2O2.	Oxygen	39-45	catalase	Homo sapiens	53-61
30888790-5	2019	The functional utility of Co(II)-MOF is demonstrated by employing it toward oxygen evolution reaction (OER) in a photoelectrochemical cell, exhibiting appreciable photocurrents of up to 5.89 mA/cm2 when used as an anode in a photoelectrochemical cell, while also displaying encouraging electrocatalytic currents of 9.32 mA/cm2 (at 2.01 V vs RHE) for the OER.	Oxygen	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
30962349-3	2019	We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays.	Oxygen	65-67	mitogen-activated protein kinase 3	Homo sapiens	128-134
30959909-7	2019	We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1).	Oxygen	29-35	collagen type II alpha 1 chain	Homo sapiens	102-108
30959909-9	2019	We found TGF-beta receptors ALK1 and ALK5 to be regulated by oxygen tension on the mRNA and protein level.	Oxygen	61-67	transforming growth factor beta 1	Homo sapiens	9-17
30876876-5	2019	Commensal-IgG immune complexes engaged gut-resident FcgammaR-expressing macrophages, inducing NLRP3- and reactive-oxygen-species-dependent production of interleukin-1beta (IL-1beta) and neutrophil-recruiting chemokines.	Oxygen	114-120	interleukin 1 beta	Mus musculus	153-170
30876876-5	2019	Commensal-IgG immune complexes engaged gut-resident FcgammaR-expressing macrophages, inducing NLRP3- and reactive-oxygen-species-dependent production of interleukin-1beta (IL-1beta) and neutrophil-recruiting chemokines.	Oxygen	114-120	interleukin 1 beta	Mus musculus	172-180
30719914-4	2019	No reaction occurred when 9,10-PQ was incubated with Na2S; however, when 5 muM 9,10-PQ was incubated with either 250 muM Na2S2 or Na2S4, we detected extensive consumption of dissolved oxygen (84 muM).	Oxygen	184-190	latexin	Homo sapiens	75-78
30864779-4	2019	It has been confirmed by both theoretical calculations and experimental methods that, benefiting from the rich amine groups and oxygen-containing functional groups, the as-prepared PPG composite film shows great ability to capture polysulfides.	Oxygen	128-134	serglycin	Homo sapiens	181-184
30848915-6	2019	Lys41 is found to guide phosphate transfer through the interactions with the beta-,gamma-, and gamma-phosphate oxygen atoms of adenosine 5"-triphosphate surrounded by two highly conserved glycine residues (Gly44 and Gly76), while Arg98 helps to position the NAG substrate in the catalytic site, which facilitates the phosphate transfer.	Oxygen	111-117	N-acetyl-alpha-glucosaminidase	Homo sapiens	258-261
29991707-3	2019	Hypoxia-dependent activation of HIF-1alpha regulates cellular O2 homeostasis.	Oxygen	62-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
30863710-1	2019	The aim of this study was to explore the neuroprotective effect and the underlying mechanism of erythropoietin (EPO) on the cortical neuronal cells insulted with oxygen and glucose deprivation (OGD).	Oxygen	162-168	erythropoietin	Homo sapiens	96-110
30863710-1	2019	The aim of this study was to explore the neuroprotective effect and the underlying mechanism of erythropoietin (EPO) on the cortical neuronal cells insulted with oxygen and glucose deprivation (OGD).	Oxygen	162-168	erythropoietin	Homo sapiens	112-115
30810066-0	2019	NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5.	Oxygen	45-51	insulin like growth factor binding protein 5	Homo sapiens	99-143
30697837-7	2019	Due to the photoformed valence band holes and selective two-electron reduction of O2 by the conduction band electrons, it also renders an efficient, economic, and green route to light-driven H2 O2 production with an initial rate of 0.75 x 10-6 m min-1 .	Oxygen	82-84	CD59 molecule (CD59 blood group)	Homo sapiens	246-251
30724472-0	2019	Efficient Fe-Co-N-C Electrocatalyst Towards Oxygen Reduction Derived from a Cationic CoII -based Metal-Organic Framework Modified by Anion-Exchange with Potassium Ferricyanide.	Oxygen	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30476008-5	2019	In the placenta, mTOR responds to a large number of growth-related signals, including amino acids, glucose, oxygen, folate, and growth factors, to regulate trophoblast mitochondrial respiration, nutrient transport, and protein synthesis, thereby influencing fetal growth.	Oxygen	108-114	mechanistic target of rapamycin kinase	Homo sapiens	17-21
30476008-6	2019	In the maternal compartment, mTOR is an integral part of a decidual nutrient sensor which links oxygen and nutrient availability to the phosphorylation of IGFBP-1 with preferential effects on the bioavailability of IGF-I in the maternal-fetal interface and in the maternal circulation.	Oxygen	96-102	mechanistic target of rapamycin kinase	Homo sapiens	29-33
30756254-7	2019	Previously, we found that HIF-1 may be associated with resistance of colorectal cancer cells to photodynamic therapy (PDT), an antitumor therapy that combines photosensitizing agents, O2 and light to create a harmful photochemical reaction.	Oxygen	184-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
29955959-9	2019	The model predicts that the optimal combination of SGLT2/SGLT1 inhibition lowers the oxygen requirements of key tubular segments, but decreases urine flow and [Formula: see text] excretion; the latter effect may limit the cardiovascular protection of the treatment.	Oxygen	85-91	solute carrier family 5 member 1	Homo sapiens	57-62
30683653-3	2019	Here, we show that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma stem cells (GSC) increases mitochondrial respiratory capacity and reduces production of reactive oxygen species.	Oxygen	247-253	sirtuin 3	Homo sapiens	133-138
30763157-0	2019	Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1beta.	Oxygen	97-103	interleukin 1 beta	Mus musculus	135-152
30611867-7	2019	Seahorse XFe-24 analyzer analysis of mitochondrial bioenergetics demonstrated an increase in oxygen consumption rate (OCR) and a decrease of extracellular acidification rate (ECAR) in Igf1r+/- cells.	Oxygen	93-99	insulin-like growth factor I receptor	Mus musculus	184-189
30507031-4	2019	Type 2-5 FE are secondary FEs caused by mutations of genes involved in oxygen sensing pathway important for erythropoietin (EPO) regulation.	Oxygen	71-77	erythropoietin	Homo sapiens	108-122
30507031-4	2019	Type 2-5 FE are secondary FEs caused by mutations of genes involved in oxygen sensing pathway important for erythropoietin (EPO) regulation.	Oxygen	71-77	erythropoietin	Homo sapiens	124-127
30684751-2	2019	Adopting zinc zeolitic imidazolate framework and graphitic carbon nitride as nitrogen-sources and templates, we herein design a facile route to fabricate an oxygen (6.11%) functionalized and heavy nitrogen (23.54%) doped porous carbon (NOC-800) with high graphitization degree, high surface area and total pore volume.	Oxygen	157-163	nocturnin	Homo sapiens	236-239
30770219-8	2019	The action of Wnt/beta-catenin was dependent on the receptor of advanced glycation end products (RAGE)-mediated NADPH oxidase induction, reactive oxygen species generation, and nuclear factor-kappaB activation.	Oxygen	146-152	Wnt family member 1	Homo sapiens	14-17
30320908-2	2019	Overexpression of human NSD3s or the yeast protein Pdp3 in Saccharomyces cerevisiae induces similar metabolic changes, including increased growth rate and sensitivity to oxidative stress, accompanied by decreased oxygen consumption.	Oxygen	213-219	Pdp3p	Saccharomyces cerevisiae S288C	51-55
30684751-3	2019	Electrochemical measurements indicate that as-obtained NOC-800 sample has satisfactory multifunctional oxygen-involving electrocatalytic properties in alkaline media, showing an onset and half-wave potential of -0.141 and -0.249 V vs. Ag/AgCl for oxygen reduction and an overpotential of 377 and 448 mV at 10 and 50 mA cm-2 for electrocatalytic oxygen evolution, respectively, even comparable to commercial RuO2 catalyst and majority of present mainstream metal-free catalysts.	Oxygen	103-109	nocturnin	Homo sapiens	55-58
30684751-3	2019	Electrochemical measurements indicate that as-obtained NOC-800 sample has satisfactory multifunctional oxygen-involving electrocatalytic properties in alkaline media, showing an onset and half-wave potential of -0.141 and -0.249 V vs. Ag/AgCl for oxygen reduction and an overpotential of 377 and 448 mV at 10 and 50 mA cm-2 for electrocatalytic oxygen evolution, respectively, even comparable to commercial RuO2 catalyst and majority of present mainstream metal-free catalysts.	Oxygen	247-253	nocturnin	Homo sapiens	55-58
30579843-5	2019	Furthermore, in vitro treatment with miR-93 agomir decreased the OGD (Oxygen and glucose deprivation)-induced proliferation of BV2 microglial cells tested by Flow cytometry.	Oxygen	70-76	microRNA 9-3	Mus musculus	37-43
30684751-3	2019	Electrochemical measurements indicate that as-obtained NOC-800 sample has satisfactory multifunctional oxygen-involving electrocatalytic properties in alkaline media, showing an onset and half-wave potential of -0.141 and -0.249 V vs. Ag/AgCl for oxygen reduction and an overpotential of 377 and 448 mV at 10 and 50 mA cm-2 for electrocatalytic oxygen evolution, respectively, even comparable to commercial RuO2 catalyst and majority of present mainstream metal-free catalysts.	Oxygen	247-253	nocturnin	Homo sapiens	55-58
30684751-4	2019	Moreover, the desirable stability of NOC-800 catalyst for both oxygen reduction and oxygen evolution reaction is also demonstrated.	Oxygen	63-69	nocturnin	Homo sapiens	37-40
30684751-4	2019	Moreover, the desirable stability of NOC-800 catalyst for both oxygen reduction and oxygen evolution reaction is also demonstrated.	Oxygen	84-90	nocturnin	Homo sapiens	37-40
30726964-10	2019	Expression of a number of RAS mRNAs (ATP6AP2, AGT, ACE and AGTR1) were increased in either, or both, 1 and 5% oxygen compared with 20% oxygen.	Oxygen	110-116	angiotensinogen	Homo sapiens	46-49
30726964-11	2019	AGT protein levels were increased in 1% oxygen compared with 5%.	Oxygen	40-46	angiotensinogen	Homo sapiens	0-3
30726964-10	2019	Expression of a number of RAS mRNAs (ATP6AP2, AGT, ACE and AGTR1) were increased in either, or both, 1 and 5% oxygen compared with 20% oxygen.	Oxygen	110-116	angiotensin I converting enzyme	Homo sapiens	51-54
30685420-3	2019	Evidence suggests that the effects of NO3- are augmented during conditions of reduced oxygen availability (e.g., hypoxia), thereby increasing the probability of performance improvements for well-trained athletes in hypoxia vs. normoxia.	Oxygen	86-92	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
30546089-8	2019	We conclude that oxygen pressure in the tumor microenvironment orchestrates an anti- and pro-tumoral gammadelta T-cell equilibrium by altering TEX content, which subsequently regulates MDSC function in a miR-21/PTEN/PD-L1-axis-dependent manner.	Oxygen	17-23	CD274 antigen	Mus musculus	216-221
30538167-5	2019	The removal of the PsbTn proteins decreased the oxygen evolution rate and PSII core phosphorylation level but increased the susceptibility of PSII to photoinhibition and the production of reactive oxygen species.	Oxygen	48-54	photosystem II subunit T	Arabidopsis thaliana	19-24
30758069-2	2019	Fast electrophilic attack to the P=O group oxygen atom is favored by exergonic CO2 release to form phosphonium Ph3 PCl+ and chloride Cl- , which may slowly cleave H2 by an unstable HPh3 PCl complex yielding Ph3 PH+ and Cl- ions in solution.	Oxygen	43-49	polyhomeotic homolog 3	Homo sapiens	181-185
30825774-5	2019	By contrast, activation by LPS led to an increased extracellular acidification rate (glycolysis) and decreased oxygen consumption rate (oxidative phosphorylation) in mouse bone marrow-derived macrophages (mBMDMs).	Oxygen	111-117	toll-like receptor 4	Mus musculus	27-30
30710412-8	2019	RESULTS: The expression of HIF-1alpha and mitochondrial NDUFA4L2 increased in NSCLC cell lines cultured in hypoxic conditions (1% O2 ).	Oxygen	130-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
32254807-2	2019	Herein, a new phototherapeutic nanoagent based on FDA-approved Prussian blue (PB) functionalized oxygen-deficient molybdenum oxide nanoparticles (MoO3-x NPs) is strategically designed and synthesized by a facile one-pot size/morphology-controlled process.	Oxygen	97-103	modifier of obesity 3	Mus musculus	146-150
32254807-3	2019	The as-prepared PB-MoO3-x nanocomposites (NCs) with a uniform particle size of ~90 nm and high water dispersibility exhibited strong optical absorption in the first biological window, which is induced by plasmon resonance in an oxygen-deficient MoO3-x semiconductor.	Oxygen	228-234	modifier of obesity 3	Mus musculus	19-23
30839954-0	2019	Unusual strain effect of a Pt-based L10 face-centered tetragonal core in core/shell nanoparticles for the oxygen reduction reaction.	Oxygen	106-112	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	36-39
30996821-2	2019	It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a pterin cofactor.	Oxygen	135-141	nitric oxide synthase 2	Homo sapiens	34-45
30909668-1	2019	In addition, low oxygen tension is able to regulate the expression of different genes involved in malignancy.In this study, we hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF-A) genes wereassessed as principal regulators of hypoxia in do novo AML patients.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-158
30909668-1	2019	In addition, low oxygen tension is able to regulate the expression of different genes involved in malignancy.In this study, we hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF-A) genes wereassessed as principal regulators of hypoxia in do novo AML patients.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
30909668-1	2019	In addition, low oxygen tension is able to regulate the expression of different genes involved in malignancy.In this study, we hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF-A) genes wereassessed as principal regulators of hypoxia in do novo AML patients.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	176-210
30909668-1	2019	In addition, low oxygen tension is able to regulate the expression of different genes involved in malignancy.In this study, we hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF-A) genes wereassessed as principal regulators of hypoxia in do novo AML patients.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	212-218
30677605-3	2019	The obtained LPC had abundant micropores (0.70 cm-3 g-1), hierarchical pore distribution (mesopore ratio: 65.8%), and an oxygen-enriched chemical structure (surface oxygen content: 16.5%).	Oxygen	121-127	proprotein convertase subtilisin/kexin type 7	Homo sapiens	13-16
30677605-3	2019	The obtained LPC had abundant micropores (0.70 cm-3 g-1), hierarchical pore distribution (mesopore ratio: 65.8%), and an oxygen-enriched chemical structure (surface oxygen content: 16.5%).	Oxygen	165-171	proprotein convertase subtilisin/kexin type 7	Homo sapiens	13-16
30949065-5	2019	Mean power output for the duration of the simulated race (91.63 +- 7.19 s) was 203.8 +- 45.0 W, incurring an oxygen deficit of 1.386 +- 0.541 L min-1 translating to an overall anaerobic contribution of 32 +- 18% and aerobic contribution of 68 +- 18%.	Oxygen	109-115	CD59 molecule (CD59 blood group)	Homo sapiens	144-149
30941102-4	2019	Bombyxin-II did not affect lipid accumulation in the hemolymph and fat body, while it increased the rate of oxygen consumption and increased the content of fructose 2, 6-bisphosphate, a potent activator of glycolysis, in the gonads, imaginal discs, and midgut.	Oxygen	108-114	bombyxin A-6	Bombyx mori	0-11
31049136-1	2019	Nitrate (NO3 -) supplementation is associated with exercise performance, oxygen uptake, blood flow, and blood pressure improvement, and it can act as an antioxidant agent.	Oxygen	73-79	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30793885-0	2019	An sp2 Patterned Boron Doped Diamond Electrode for the Simultaneous Detection of Dissolved Oxygen and pH.	Oxygen	91-97	Sp2 transcription factor	Homo sapiens	3-6
30793885-1	2019	A hybrid sp2-sp3 electrochemical sensor comprising patterned regions of nondiamond-carbon (sp2) in a boron doped diamond (sp3) matrix is described for the simultaneous voltammetric detection of dissolved oxygen (DO) and pH in buffered aqueous solutions.	Oxygen	204-210	Sp2 transcription factor	Homo sapiens	9-12
30793885-1	2019	A hybrid sp2-sp3 electrochemical sensor comprising patterned regions of nondiamond-carbon (sp2) in a boron doped diamond (sp3) matrix is described for the simultaneous voltammetric detection of dissolved oxygen (DO) and pH in buffered aqueous solutions.	Oxygen	204-210	Sp3 transcription factor	Homo sapiens	13-16
30793885-1	2019	A hybrid sp2-sp3 electrochemical sensor comprising patterned regions of nondiamond-carbon (sp2) in a boron doped diamond (sp3) matrix is described for the simultaneous voltammetric detection of dissolved oxygen (DO) and pH in buffered aqueous solutions.	Oxygen	204-210	Sp2 transcription factor	Homo sapiens	91-94
30793885-1	2019	A hybrid sp2-sp3 electrochemical sensor comprising patterned regions of nondiamond-carbon (sp2) in a boron doped diamond (sp3) matrix is described for the simultaneous voltammetric detection of dissolved oxygen (DO) and pH in buffered aqueous solutions.	Oxygen	204-210	Sp3 transcription factor	Homo sapiens	122-125
30793885-3	2019	These regions both promote the electrocatalytic reduction of oxygen and facilitate the proton coupled electron transfer of quinone groups, integrated into the surface of the sp2 carbon.	Oxygen	61-67	Sp2 transcription factor	Homo sapiens	174-177
30901878-6	2019	For the range of [PA]0 covered under air saturated conditions and 30 mL min-1 flow of air in this setup, the estimated half-lives of O2(aq) consumed by the photolytic radicalsfall within the interval from 22 to 3 min.	Oxygen	133-135	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
30834901-4	2019	At 900  C, oxygen fluxes of 1.01 mL min-1 cm-2 and 1.33 mL min-1 cm-2 were obtained for membranes with thicknesses of 1.35 mm and 0.75 mm, respectively.	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	36-52
30834901-4	2019	At 900  C, oxygen fluxes of 1.01 mL min-1 cm-2 and 1.33 mL min-1 cm-2 were obtained for membranes with thicknesses of 1.35 mm and 0.75 mm, respectively.	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
30692269-9	2019	IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose.	Oxygen	136-142	insulin-like growth factor 2 mRNA binding protein 2	Mus musculus	0-4
30692269-9	2019	IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose.	Oxygen	185-191	insulin-like growth factor 2 mRNA binding protein 2	Mus musculus	0-4
30889848-13	2019	This result implies that supercritical CO2 exposure has potential to limit physical aging performance loss in PIM-1 based membranes for O2/N2 separation.	Oxygen	40-42	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	110-115
30930751-3	2019	In this study, we found that Homer1a was upregulated by oxygen and glucose deprivation (OGD) and that overexpression of Homer1a alleviated OGD-induced lactate dehydrogenase (LDH) release and cell death in cultured cortical neurons.	Oxygen	56-62	homer scaffold protein 1	Homo sapiens	29-36
30810308-0	2019	Mechanistic Insight into Dioxygen Evolution from Diastereomeric mu-Peroxo Dinuclear Co(III) Complexes Based on Stoichiometric Electron-Transfer Oxidation.	Oxygen	25-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	84-91
30810308-1	2019	Stoichiometric electron-transfer (ET) oxidation of two diastereomeric mu-peroxo-mu-hydroxo dinuclear Co(III) complexes with tris(2-pyridylmethyl)amine (TPA) was examined to scrutinize the reaction mechanism of O2 evolution from the peroxo complexes, as seen in the final step in water oxidation by a Co(III)-TPA complex.	Oxygen	210-212	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	101-108
30810308-1	2019	Stoichiometric electron-transfer (ET) oxidation of two diastereomeric mu-peroxo-mu-hydroxo dinuclear Co(III) complexes with tris(2-pyridylmethyl)amine (TPA) was examined to scrutinize the reaction mechanism of O2 evolution from the peroxo complexes, as seen in the final step in water oxidation by a Co(III)-TPA complex.	Oxygen	210-212	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	104-107
30810308-6	2019	ET-oxidation rate constants of the isomers were determined to be much faster than the O2-evolving rate constants, indicating that the O2-releasing step is the rate-determining step in the O2 evolution through the stoichiometric ET oxidation of the dinuclear Co(III)-mu-peroxo complexes.	Oxygen	86-88	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	261-264
30810308-6	2019	ET-oxidation rate constants of the isomers were determined to be much faster than the O2-evolving rate constants, indicating that the O2-releasing step is the rate-determining step in the O2 evolution through the stoichiometric ET oxidation of the dinuclear Co(III)-mu-peroxo complexes.	Oxygen	134-136	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	261-264
30810308-7	2019	Therefore, the difference of reactivity in the O2 evolution for the two isomers should be derived from the thermodynamic stability of two-electron oxidized species of the dinuclear Co(III)-mu-peroxo complexes, mu-dioxygen-mu-hydroxo dinuclear Co(III) intermediates.	Oxygen	47-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	184-187
30810308-7	2019	Therefore, the difference of reactivity in the O2 evolution for the two isomers should be derived from the thermodynamic stability of two-electron oxidized species of the dinuclear Co(III)-mu-peroxo complexes, mu-dioxygen-mu-hydroxo dinuclear Co(III) intermediates.	Oxygen	47-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	181-188
30810308-7	2019	Therefore, the difference of reactivity in the O2 evolution for the two isomers should be derived from the thermodynamic stability of two-electron oxidized species of the dinuclear Co(III)-mu-peroxo complexes, mu-dioxygen-mu-hydroxo dinuclear Co(III) intermediates.	Oxygen	213-221	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	184-187
30551085-3	2019	Results indicated that lysozyme boosted the ES hydrolysis significantly with approximately 236.5 mg/L soluble chemical oxygen demand (SCOD), 58.6 mg/L polysaccharide and 662.7 mg/L protein release within 240 min at the lysozyme dosage of 150 mg/gSS.	Oxygen	119-125	lysozyme	Homo sapiens	23-31
30872525-0	2019	Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.	Oxygen	42-48	lysine demethylase 6A	Homo sapiens	20-25
30872525-6	2019	We found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM6B, is oxygen sensitive.	Oxygen	85-91	lysine demethylase 6A	Homo sapiens	44-49
30872525-6	2019	We found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM6B, is oxygen sensitive.	Oxygen	85-91	lysine demethylase 6A	Homo sapiens	50-53
31087986-3	2019	In the experiment, when the concentration of dissolved oxygen was 6.5 mg L-1 and the sludge age was 30 days, the effluent TP was less than 0.5 mg L-1, the concentration of COD was less than 50 mg L-1, and the accumulation rate of nitrite nitrogen was above 90%.	Oxygen	55-61	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
31001558-2	2019	Hypoxia-inducible factor-1A (HIF-1A) helps maintain oxygen homeostasis by promoting the transcription of various genes and can be affected by ROS levels.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-27
31001558-2	2019	Hypoxia-inducible factor-1A (HIF-1A) helps maintain oxygen homeostasis by promoting the transcription of various genes and can be affected by ROS levels.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-35
30875802-3	2019	The catalytic domain of FGFR1 fused to the algal light-oxygen-voltage-sensing (LOV) domain was directed to different cellular compartments (plasma membrane, cytoplasm and nucleus) in human embryonic kidney (HEK293) and pheochromocytoma (PC12) cells.	Oxygen	55-61	fibroblast growth factor receptor 1	Homo sapiens	24-29
31087986-3	2019	In the experiment, when the concentration of dissolved oxygen was 6.5 mg L-1 and the sludge age was 30 days, the effluent TP was less than 0.5 mg L-1, the concentration of COD was less than 50 mg L-1, and the accumulation rate of nitrite nitrogen was above 90%.	Oxygen	55-61	immunoglobulin kappa variable 1-16	Homo sapiens	146-149
31087986-3	2019	In the experiment, when the concentration of dissolved oxygen was 6.5 mg L-1 and the sludge age was 30 days, the effluent TP was less than 0.5 mg L-1, the concentration of COD was less than 50 mg L-1, and the accumulation rate of nitrite nitrogen was above 90%.	Oxygen	55-61	immunoglobulin kappa variable 1-16	Homo sapiens	146-149
30787190-8	2019	Two EOPE TB modules, EOPE1 and EOPE2, also correlated positively and negatively, respectively, with 20% O2 conditions, but only weakly with invasion; they largely contained the same sets of genes present in modules CTL4 and CTL9.	Oxygen	104-106	solute carrier family 44 member 4	Homo sapiens	215-219
30475644-0	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Oxygen	170-172	catalase	Mus musculus	122-130
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Oxygen	170-172	catalase	Mus musculus	132-135
30373378-9	2019	Using logistic regression analysis, a unique pattern of pre-exercise miR-150-5p, post-exercise miR-101-3p, miR-141-3p and miR-200b-3p together with maximal oxygen uptake and maximal power corrected for bodyweight allowed discrimination between healthy subjects and CAD patients with an accuracy of 92.5%.	Oxygen	156-162	microRNA 200b	Homo sapiens	122-130
30475644-9	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
30843740-0	2019	Insulin resistance and diabetes in hyperthyroidism: a possible role for oxygen and nitrogen reactive species.	Oxygen	72-78	insulin	Homo sapiens	0-7
30390406-4	2019	ASC viability following encapsulation and culture under 2% O2 was significantly impaired in the MGC-IKVAV group relative to the MGC and MGC-RGD groups.	Oxygen	59-61	PYD and CARD domain containing	Homo sapiens	0-3
30686087-9	2019	Overexpression of SCO2 restored the beneficial effect of CR on antagonizing Ang II-induced expression of AAA-related molecules and reactive oxygen species generation in p53-/- vascular smooth muscle cells.	Oxygen	140-146	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	76-82
30658160-9	2019	Calcitriol increased oxygen consumption rate while PLIN2 knockdown decreased oxygen consumption rate.	Oxygen	77-83	perilipin 2	Homo sapiens	51-56
30469179-4	2019	The samples deposited with an oxygen partial pressure of 12% showed the best p-type characteristics, which included a maximum hole mobility of 1.94 cm2/Vs, carrier concentration of 3.83x1017/cm3, Sn2+ peak area percentage of 91.34%, Sn4+ peak area percentage of 2.35%, and Sn0 peak area percentage of 6.31%.	Oxygen	30-36	solute carrier family 38 member 5	Homo sapiens	196-199
30469179-5	2019	As the oxygen partial pressure was increased to more than 12%, the Sn2+ peak area percentage decreased while the Sn4+ peak area percentage increased.	Oxygen	7-13	solute carrier family 38 member 5	Homo sapiens	67-70
30658160-10	2019	PLIN2 was required for a calcitriol-induced increase in oxygen consumption driven by mitochondrial complex II.	Oxygen	56-62	perilipin 2	Homo sapiens	0-5
30693780-1	2019	The rhodium/O2 system-catalyzed distal C(sp2)-H olefination of quinoline N-oxides is developed.	Oxygen	12-14	Sp2 transcription factor	Homo sapiens	39-44
30808328-7	2019	Furthermore, low oxygen levels generate HIF1A-dependent or HIF1A-independent signatures, able to stratify patients according to risk categories.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
30641122-17	2019	The presence of a minor allele in G894T polymorphism of the NOS3 gene contributes to formation of oxygen transport function of blood.	Oxygen	98-104	nitric oxide synthase 3	Homo sapiens	60-64
30911278-0	2019	Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages.	Oxygen	18-24	endothelin 1	Rattus norvegicus	58-70
30911278-0	2019	Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages.	Oxygen	18-24	nitric oxide synthase 2	Rattus norvegicus	72-76
30768111-3	2019	Exposure to air of dichloromethane solutions of complexes 1 and 2 produced dioxygen derivatives [Os(eta5-C5Me5)(eta2-O2)(PPh3){P(OR)3}]BPh4 (10, 11) [R = Me (10), Et (11)].	Oxygen	75-83	caveolin 1	Homo sapiens	121-125
30609375-8	2019	Our data reveal time-resolved changes in the regulation of metabolic proteins under oxygen-deprived conditions and elucidate GLUL as a strong responder to HIFs and the hypoxic environment.	Oxygen	84-90	glutamate-ammonia ligase	Homo sapiens	125-129
30867760-0	2019	Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-alpha and IL-6 levels.	Oxygen	11-17	tumor necrosis factor	Homo sapiens	81-90
30867760-0	2019	Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-alpha and IL-6 levels.	Oxygen	11-17	interleukin 6	Homo sapiens	95-99
30508716-0	2019	PPCP degradation and DBP formation in the solar/free chlorine system: Effects of pH and dissolved oxygen.	Oxygen	98-104	D-box binding PAR bZIP transcription factor	Homo sapiens	21-24
30813522-7	2019	Oxygen stable isotope ratios in milk water were relatively lower in winter and transitional seasons and higher in summer, showing the dependence on the main water source.	Oxygen	0-6	Weaning weight-maternal milk	Bos taurus	32-36
30808328-7	2019	Furthermore, low oxygen levels generate HIF1A-dependent or HIF1A-independent signatures, able to stratify patients according to risk categories.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-64
30915350-6	2019	Furthermore, downregulation of TNKS suppressed the glucose uptake, lactate excretion, and cellular ATP levels and increased cellular O2 consumption rates.	Oxygen	133-135	tankyrase	Homo sapiens	31-35
30796298-5	2019	Instead, a bienzymatic oxygen scavenger system comprising glucose oxidase and catalase can be used to promote anoxic conditions in aired environments.	Oxygen	23-29	catalase	Homo sapiens	78-86
30808910-3	2019	Hypoxia-inducible factor 1 alpha (Hif-1alpha) is a necessary component of the cellular oxygen-sensing machinery and has been implicated as a major regulator of trophoblast differentiation.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
30808910-3	2019	Hypoxia-inducible factor 1 alpha (Hif-1alpha) is a necessary component of the cellular oxygen-sensing machinery and has been implicated as a major regulator of trophoblast differentiation.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
30357211-8	2019	By comparing the variation in the binding energy of Ti 2p to that of C 1s, and observing how the variation changes for different excitation signals (at different frequency and amplitudes), it is possible to inspect the effect of the oxygen vacancy drift.	Oxygen	233-239	complement C1s	Homo sapiens	69-73
30633519-2	2019	CYP450 is a nanomachine that uses dioxygen and two reducing and two proton equivalents to oxidize a plethora of molecules (so-called substrates) as a means of supplying bio-organisms with essential molecules (e.g., brain neurotransmitters, sex hormones, etc.)	Oxygen	34-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-6
30620788-6	2019	Porous carbon tri-doped with nitrogen, phosphorous, and oxygen exhibits a high packing density (2.13 g cm-3 ) and an exceptional volumetric energy density (36.8 Wh L-1 ) in alkaline electrolytes, making it competitive to even some Ni-MH cells.	Oxygen	56-62	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
30784061-3	2019	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a core factor that mediates hypoxia stress responses and allows the cells to adapt to low-oxygen conditions.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
30784061-3	2019	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a core factor that mediates hypoxia stress responses and allows the cells to adapt to low-oxygen conditions.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
30770797-4	2019	Overexpression of Fhit protein in Fhit-deficient cancer cells modulates the production of intracellular reactive oxygen species, causing increased ROS, following peroxide treatment, with subsequent increased apoptosis of lung cancer cells under oxidative stress conditions; conversely, Fhit-negative cells escape ROS overproduction and ROS-induced apoptosis, likely carrying oxidative damage.	Oxygen	113-119	fragile histidine triad gene	Mus musculus	18-22
30911355-1	2019	Multiple signaling pathways including ERK, PI3K-Akt, and NF-kappaB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2  - into H2O2.	Oxygen	188-190	nuclear factor kappa B subunit 1	Homo sapiens	57-66
30911355-1	2019	Multiple signaling pathways including ERK, PI3K-Akt, and NF-kappaB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2  - into H2O2.	Oxygen	188-190	superoxide dismutase 1	Homo sapiens	273-277
30770797-4	2019	Overexpression of Fhit protein in Fhit-deficient cancer cells modulates the production of intracellular reactive oxygen species, causing increased ROS, following peroxide treatment, with subsequent increased apoptosis of lung cancer cells under oxidative stress conditions; conversely, Fhit-negative cells escape ROS overproduction and ROS-induced apoptosis, likely carrying oxidative damage.	Oxygen	113-119	fragile histidine triad gene	Mus musculus	34-38
30755634-4	2019	In this work, we fabricated microwell spheroid culture devices made of oxygen-permeable polydimethylsiloxane (PDMS), with which hypoxia in the core of bioartificial islets was alleviated and glucose-stimulated insulin secretion was increased ~2.5-fold compared to a device with the same configuration but made of non-oxygen-permeable plastic.	Oxygen	71-77	insulin	Homo sapiens	210-217
30837842-5	2019	Using an immortalized hippocampal cell line, we observed significant reductions in several parameters of mitochondrial oxygen consumption after a 24-h exposure period to TNF-alpha.	Oxygen	119-125	tumor necrosis factor	Homo sapiens	170-179
30815434-2	2019	IL-1beta signaling leads to parturition in preterm birth (PTB) and contributes to the retinal vaso-obliteration characteristic of oxygen-induced retinopathy (OIR) of premature infants.	Oxygen	130-136	interleukin 1 beta	Homo sapiens	0-8
30792696-3	2019	Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus.	Oxygen	104-110	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
30605314-1	2019	Measurements of the stable isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3-) enable identification of sources, dispersal, and fate of natural and contaminant NO3- in aquatic environments.	Oxygen	68-74	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
30605314-2	2019	The 18O/16O of NO3- produced by nitrification is often assumed to reflect the proportional contribution of oxygen atom sources, water, and molecular oxygen, in a 2:1 ratio.	Oxygen	107-113	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
30605314-2	2019	The 18O/16O of NO3- produced by nitrification is often assumed to reflect the proportional contribution of oxygen atom sources, water, and molecular oxygen, in a 2:1 ratio.	Oxygen	149-155	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
30605314-3	2019	Culture and seawater incubations, however, indicate oxygen isotopic equilibration between nitrite (NO2-) and water, and kinetic isotope effects for oxygen atom incorporation, which modulate the NO3- 18O/16O produced during nitrification.	Oxygen	148-154	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
30605314-5	2019	Resulting NO3- 18O/16O ratios showed (1) a disproportionate sensitivity to the 18O/16O ratio of water, mediated by isotopic equilibration between water and NO2-, as well as (2) kinetic isotope discrimination during O atom incorporation from molecular oxygen and water.	Oxygen	251-257	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30388689-7	2019	MSH could be removed over 95% under the condition of 2 s of residence time, 15 kV of output voltage with oxygen concentration of 9%.	Oxygen	105-111	msh homeobox 2	Homo sapiens	0-3
30520688-4	2019	Breathing normobaric 11% O2 prevents neurological disease and improves survival in Ndufs4-/- mice.	Oxygen	25-27	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	83-89
30520688-6	2019	In mice breathing air, the partial pressure of arterial oxygen during LMBO was lower in Ndufs4-/- and in piericidin A-treated Ndufs4+/+ mice than in respective controls.	Oxygen	56-62	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	88-94
30520688-6	2019	In mice breathing air, the partial pressure of arterial oxygen during LMBO was lower in Ndufs4-/- and in piericidin A-treated Ndufs4+/+ mice than in respective controls.	Oxygen	56-62	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	126-132
30520688-8	2019	In Ndufs4-deficient mice, 3 wk of breathing 11% O2 restored HPV in response to LMBO.	Oxygen	48-50	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	3-9
30453214-3	2019	The hybridized nanoplatform (R-MnO2-FBP) was prepared by assembly of Rhodamine B (RhB)-encapsulated manganese dioxide (R-MnO2) as O2 supplier and indicator, and fluorescein isothiocyanate (FITC)-labelled peptide-functionalized black phosphorus as the theranostic agent.	Oxygen	33-35	ECB2	Homo sapiens	36-39
30453214-4	2019	The time-dependent assays suggested that the O2 release was proportional to the liberation of Mn2+ and RhB in the R-MnO2-FBP system.	Oxygen	45-47	ECB2	Homo sapiens	121-124
30453214-5	2019	After specific delivery into cancer cells, R-MnO2-FBP was dissociated in the acidic and H2O2-rich environment and generated oxygen to overcome hypoxia-associated PDT resistance.	Oxygen	124-130	ECB2	Homo sapiens	50-53
30535970-9	2019	These data demonstrate the importance of ERK-mediated activation of HIF-1 for low oxygen adaptation and the applicability of ETD peptide derivatives as sequence-specific HIF-1 and cancer cell growth inhibitors under hypoxia.	Oxygen	82-88	mitogen-activated protein kinase 1	Homo sapiens	41-44
30535970-9	2019	These data demonstrate the importance of ERK-mediated activation of HIF-1 for low oxygen adaptation and the applicability of ETD peptide derivatives as sequence-specific HIF-1 and cancer cell growth inhibitors under hypoxia.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-73
30284087-4	2019	The strategy adopted includes a combination of erythropoietin and other injectable drugs under low oxygen levels, which resulted in an increase in the number of mature RBCs produced in vitro.	Oxygen	99-105	erythropoietin	Homo sapiens	47-61
30638307-0	2019	The effect of isolated nocturnal oxygen desaturations on serum hs-CRP and IL-6 in patients with chronic obstructive pulmonary disease.	Oxygen	33-39	interleukin 6	Homo sapiens	74-78
30638307-3	2019	OBJECTIVES: We aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs-CRP and IL-6 than those who did not meet the guidelines for iNOT (iNOT-).	Oxygen	97-103	C-reactive protein	Homo sapiens	140-143
30638307-3	2019	OBJECTIVES: We aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs-CRP and IL-6 than those who did not meet the guidelines for iNOT (iNOT-).	Oxygen	97-103	interleukin 6	Homo sapiens	148-152
30443753-5	2019	METHODS: CD5-2 was tested in three mouse models of retinal dysfunction: conditional Muller cell depletion, streptozotocin-induced diabetes and oxygen-induced retinopathy.	Oxygen	143-149	CD52 antigen	Mus musculus	9-14
30638307-9	2019	CONCLUSION: COPD patients who have more than 5 minutes and 5% of their sleep time spent at oxygen saturation less than 88% have increased hs-CRP, which is associated with increased risk of future CVD.	Oxygen	91-97	C-reactive protein	Homo sapiens	141-144
29947971-8	2019	This decoupling allows bacteria to sense oxygen and regulate the amount of variability in TMAO reductase expression (that is, to turn bet hedging on or off) without having to adjust the mean TMAO reductase expression level.	Oxygen	41-47	putative DNA recombination protein Bet	Escherichia coli	134-137
30443753-11	2019	RESULTS: CD5-2 penetrated the vasculature of the eye in the oxygen-induced retinopathy model.	Oxygen	60-66	CD52 antigen	Mus musculus	9-14
30443753-12	2019	Treatment of diseased mice with CD5-2 resulted in reduced vascular leak in all three animal models, enhanced expression of VE-cadherin in the microvessels of the eye and improved pericyte coverage of the retinal vasculature in streptozotocin-induced diabetic models and oxygen-induced retinopathy models.	Oxygen	270-276	CD52 antigen	Mus musculus	32-37
30547349-5	2019	Reviewing the emerging dataset, we underline this unanticipated phenotypic consequence of pathogenic FLNA mutation-associated pulmonary disease.Conclusion: From the emerging data, we suggest that while reviewing complex cases with a sustained oxygen requirement against a clincial background of cardiac concerns or intestinal obstruction to have a high index of suspicion for FLNA related pathology and to instigate early MRI brain scan and FLNA mutation analysis.	Oxygen	243-249	filamin A	Homo sapiens	101-105
30471165-5	2019	HIF-1 is to a large degree regulated by the availability of oxygen as in its presence, the subunit HIF-1alpha is degraded by HIF prolyl hydroxylase enzymes (HPHs).	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
30471165-5	2019	HIF-1 is to a large degree regulated by the availability of oxygen as in its presence, the subunit HIF-1alpha is degraded by HIF prolyl hydroxylase enzymes (HPHs).	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
30471165-8	2019	Treatment with all HPH inhibitors at high oxygen tension (20%) resulted in HIF-1alpha stabilization as assessed by immunocytochemistry for HIF-1alpha and detection of increased levels of vascular endothelial growth factor in the conditioned culture medium.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
30471165-8	2019	Treatment with all HPH inhibitors at high oxygen tension (20%) resulted in HIF-1alpha stabilization as assessed by immunocytochemistry for HIF-1alpha and detection of increased levels of vascular endothelial growth factor in the conditioned culture medium.	Oxygen	42-48	vascular endothelial growth factor A	Homo sapiens	187-221
31031250-3	2019	The results show that the spatial distribution of the snail populations is related to pH, dissolved oxygen (mg/l), conductivity, temperature (C), and water flow velocity (m/s).	Oxygen	100-106	snail family transcriptional repressor 1	Homo sapiens	54-59
30400060-3	2019	Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen.	Oxygen	240-246	mechanistic target of rapamycin kinase	Homo sapiens	105-136
30400060-3	2019	Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen.	Oxygen	240-246	mechanistic target of rapamycin kinase	Homo sapiens	138-142
29717493-14	2019	Incubation of PA with Su5416 and hypoxia (3% O2 ) increased miR-1 and induced a decline in Kv1.5 currents, which was prevented by antagomiR-1.	Oxygen	45-47	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	91-96
30188362-1	2019	INTRODUCTION: Recombinant human erythropoietin (rHuEpo) administration enhances oxygen carrying capacity and performance at sea level.	Oxygen	80-86	erythropoietin	Homo sapiens	32-46
30535469-4	2019	As a key downstream protein of the PI3K/Akt signaling pathway, hypoxia-inducible factor (HIF)-1 is closely associated with the concentration of oxygen in the environment.	Oxygen	144-150	AKT serine/threonine kinase 1	Homo sapiens	40-43
30536571-5	2019	Hypoxia (1% O2 ) induced high expression of both HIF-1alpha and especially HIF-2alpha, and increased the resistance of OVCAR-3 S and CAOV-3 S cells to ADR.	Oxygen	12-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
30535469-4	2019	As a key downstream protein of the PI3K/Akt signaling pathway, hypoxia-inducible factor (HIF)-1 is closely associated with the concentration of oxygen in the environment.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-95
30657490-6	2019	Equally important is the fact that the position of both the conduction and valence band edges of the h-BCH sheet matches well with the chemical reaction potential of H2/H+ and O2/H2O, giving a 2D photocatalyst as a potential candidate for overall visible-light-driven water splitting.	Oxygen	176-178	chimerin 2	Homo sapiens	103-106
30756520-8	2019	Mitochondrial reactive oxygen species production per oxygen consumed was elevated in aged Nrf2 KO mice.	Oxygen	23-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
29781952-10	2019	RESULTS: Simulation revealed that 12 C of 50% O2 PIM-R culture supplied O2 effectively into the islet core.	Oxygen	46-48	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	49-52
29781952-10	2019	RESULTS: Simulation revealed that 12 C of 50% O2 PIM-R culture supplied O2 effectively into the islet core.	Oxygen	72-74	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	49-52
31250610-0	2019	[Effects of Notch signal on the expressions of HIF-alpha and autophagy- related genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation induced myocardial cell injury].	Oxygen	110-116	notch receptor 1	Homo sapiens	12-17
30699348-3	2019	Studies of SCA7 mice uncovered marked impairments in oxygen consumption and respiratory exchange.	Oxygen	53-59	ataxin 7	Mus musculus	11-15
30774348-0	2019	Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3beta/beta-catenin pathway.	Oxygen	11-17	thymoma viral proto-oncogene 1	Mus musculus	94-97
30679577-3	2019	Compared to the conventional process of overnight oxidation, only ~10 s of oxygen/argon mixture plasma treatment is enough for the solar cell devices with FTO/ETL/perovskite/HTL/Au structure demonstrating a high power conversion efficiency.	Oxygen	75-81	adhesion G protein-coupled receptor L4	Homo sapiens	159-162
30697423-10	2019	TPD54 knockdown increased PDH E1alpha protein degradation and led to decreased PDH enzyme activity, which reduced mitochondrial oxygen consumption and reactive oxygen species (ROS) production, thus contributing to the resistance of breast cancer cells to metformin treatment.	Oxygen	128-134	TPD52 like 2	Homo sapiens	0-5
30697423-10	2019	TPD54 knockdown increased PDH E1alpha protein degradation and led to decreased PDH enzyme activity, which reduced mitochondrial oxygen consumption and reactive oxygen species (ROS) production, thus contributing to the resistance of breast cancer cells to metformin treatment.	Oxygen	128-134	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	79-82
30391318-0	2019	Effect of hyperbaric oxygen therapy on HMGB1/NF-kappaB expression and prognosis of acute spinal cord injury: A randomized clinical trial.	Oxygen	21-27	nuclear factor kappa B subunit 1	Homo sapiens	45-54
30552009-1	2019	A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesized using ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-l-glutamic acid, as a molecular template in order to better understand the impact of replacing one of the two nitrogen atoms in the urea-based GCPII inhibitor with an oxygen atom.	Oxygen	340-346	folate hydrolase 1	Homo sapiens	42-71
30669593-10	2019	Finally, transcription of HIF1A mRNA differs in response to chronic and intermittent hypoxia suggesting that HIF-1alpha may be regulated at the transcriptional level in intermittent hypoxia and not just by the post-translational oxygen-dependent degradation pathway seen in chronic hypoxia.	Oxygen	229-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
30669593-10	2019	Finally, transcription of HIF1A mRNA differs in response to chronic and intermittent hypoxia suggesting that HIF-1alpha may be regulated at the transcriptional level in intermittent hypoxia and not just by the post-translational oxygen-dependent degradation pathway seen in chronic hypoxia.	Oxygen	229-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
30774414-0	2019	Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.	Oxygen	11-17	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
30670058-2	2019	The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose transcriptional activity is canonically regulated through their oxygen-labile HIF-alpha subunits.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-97
30670058-3	2019	These are constitutively degraded in the presence of oxygen; however, HIF-1alpha can be stabilised, even at high oxygen concentrations, through the activation of HER receptor signalling.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
30666472-11	2019	CONCLUSION: According to our results, PPG-RR is an interesting approach for ventilation monitoring, as this technique would make simultaneous monitoring of respiratory rate and arterial oxygen saturation possible, thus minimizing the number of sensors attached to the patient.	Oxygen	186-192	serglycin	Homo sapiens	38-41
30552009-1	2019	A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesized using ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-l-glutamic acid, as a molecular template in order to better understand the impact of replacing one of the two nitrogen atoms in the urea-based GCPII inhibitor with an oxygen atom.	Oxygen	340-346	folate hydrolase 1	Homo sapiens	73-78
30630244-13	2019	As exercise power increases, the heart oxygen consumption per stroke and the amount of volume and oxygen re-quired for gax exchange does increase.	Oxygen	39-45	mesenchyme homeobox 2	Homo sapiens	119-122
30787979-10	2019	Activation of the Nrf2 pathway as well as the protective effects of Sch A in an oxygen and glucose deprivation-induced injury model was abolished by AMPK knockdown.	Oxygen	80-86	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
30342030-7	2019	More importantly, we firstly find resveratrol stimulates the cardiac mitochondrial activities, but silencing Err-alpha decreased mitochondrial function on ATP production, oxygen consumption and complex I activity.	Oxygen	171-177	estrogen related receptor, alpha	Mus musculus	109-118
30642030-1	2019	The hypoxia-inducible transcription factors (HIF)-1/2alpha are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-58
30547578-2	2019	In this situation, chiral epoxides can successfully be incorporated into the cleft of V-shaped host BP1 by double coordination of both oxygen lone pairs of the guest to the two central zinc ions of the host.	Oxygen	135-141	BP1	Homo sapiens	100-103
30630244-13	2019	As exercise power increases, the heart oxygen consumption per stroke and the amount of volume and oxygen re-quired for gax exchange does increase.	Oxygen	98-104	mesenchyme homeobox 2	Homo sapiens	119-122
30656220-3	2019	Our previous studies have suggested that alteration of oxygen homeostasis may be involved in the kidney injury caused by AQP11 deficiency, although the underlying mechanism is largely unknown.	Oxygen	55-61	aquaporin 11	Mus musculus	121-126
30656220-4	2019	To clarify this issue, we examined genes that are related to oxygen homeostasis in Aqp11 -/- mice.	Oxygen	61-67	aquaporin 11	Mus musculus	83-88
31225497-1	2019	Hypoxia-Inducible Factor (HIF)-1 is a transcription factor that plays the key role in response to low oxygen concentrations, or hypoxia.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
30656220-5	2019	Among 62 genes that are involved in oxygen homeostasis, 35 were upregulated by more than 2-fold in Aqp11 -/- mice in comparison with wild-type mice.	Oxygen	36-42	aquaporin 11	Mus musculus	99-104
30656220-9	2019	These results indicate that NOX2-induced oxidative stress accompanied by macrophage infiltration plays an important role in alteration of oxygen homeostasis in Aqp11 -/- mice.	Oxygen	138-144	aquaporin 11	Mus musculus	160-165
30634998-14	2019	Interestingly, the Oxygen Consumption Rates (OCR) was increased in M(LPS + IFNgamma) microglia but reduced in M(IL-4) microglia by STF31 treatment.	Oxygen	19-25	interferon gamma	Mus musculus	75-83
30755771-0	2019	Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study.	Oxygen	28-34	nitric oxide synthase 2	Homo sapiens	38-69
30755771-1	2019	This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients.	Oxygen	62-68	nitric oxide synthase 2	Homo sapiens	87-118
30755771-1	2019	This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients.	Oxygen	62-68	nitric oxide synthase 2	Homo sapiens	120-124
30625200-5	2019	We focused on oxygen uptake standards and compared the maximal oxygen uptake [mLO2 kg-1 min-1] values with those in the existing literature.	Oxygen	63-69	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
30625200-11	2019	In our cohort, the 50th percentile maximal oxygen uptake values for men and women decreased from 44.7 and 36.3 mLO2 kg-1 min-1 to 28.4 and 22.3 mLO2 kg-1 min-1 for patients aged 20-29 years to patients aged 60-69 years, respectively.	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
30625200-11	2019	In our cohort, the 50th percentile maximal oxygen uptake values for men and women decreased from 44.7 and 36.3 mLO2 kg-1 min-1 to 28.4 and 22.3 mLO2 kg-1 min-1 for patients aged 20-29 years to patients aged 60-69 years, respectively.	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	154-159
31225497-4	2019	It is well established that oxygen tension in solid tumor tissue induces the aberrant activation of the HIF-1 pathway, and subsequently promotes angiogenesis and tumor progression.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-109
31225497-7	2019	The differential activation of the HIF-1 pathway in breast cancer subtypes suggests that oxygen-independent pathways may be involved in HIF-1 regulation during TNBC progression.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
31225497-7	2019	The differential activation of the HIF-1 pathway in breast cancer subtypes suggests that oxygen-independent pathways may be involved in HIF-1 regulation during TNBC progression.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-141
31073929-10	2019	The increase in PRL likely reflects a stress response after physical exercise, amplified by hyperbaric oxygen.	Oxygen	103-109	prolactin	Homo sapiens	16-19
30413532-4	2019	We demonstrate that TRPC5 is involved in endothelial cell sprouting, angiogenesis, and blood perfusion in an oxygen-induced retinopathy model and a hind limb ischemia model.	Oxygen	109-115	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	20-25
30609861-4	2019	In this study, chloramphenicol was found to repress the oxygen-labile transcription factor, hypoxia inducible factor-1 alpha (HIF-1alpha), in hypoxic A549 and H1299 cells.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-124
30609861-4	2019	In this study, chloramphenicol was found to repress the oxygen-labile transcription factor, hypoxia inducible factor-1 alpha (HIF-1alpha), in hypoxic A549 and H1299 cells.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	207-213	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
31562623-1	2019	The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	207-213	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
30468780-6	2019	The identified element conferred oxygen sensitivity to otherwise hypoxia-resistant WT1 and SV40 promoter constructs.	Oxygen	33-39	WT1 transcription factor	Homo sapiens	83-86
31201718-3	2019	Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1beta subunit and an oxygen sensitive HIF-1alpha subunit, thus, adapts to decreased oxygen availability as a transcriptional factor.	Oxygen	207-213	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
30994625-4	2019	Injection of this drug to the ischaemised tissues of lower extremities ensures long-term synthesis of vascular endothelial growth factor 165 leading to the development of an additional collateral vascular network and consequently to increased perfusion of tissues with oxygen and decreased degree of ischaemia.	Oxygen	269-275	vascular endothelial growth factor A	Homo sapiens	102-136
30468780-9	2019	These findings demonstrate that binding of HIF-2alpha to an oxygen-sensitive enhancer in intron 3 stimulates transcription of the WT1 gene in neuroblastoma cells by hypoxia-independent chromatin looping.	Oxygen	60-66	WT1 transcription factor	Homo sapiens	130-133
30460429-3	2019	Here, we showed that under oxygen-glucose deprivation and reperfusion (OGD/R), APC-Cdh1 was decreased in primary cortical neurons.	Oxygen	27-33	cadherin 1	Homo sapiens	83-87
30120048-9	2019	In addition, secreted frizzled-related protein 5 was negatively correlated with homeostasis model assessment of insulin resistance but positively correlated with the mean and lowest oxygen saturation with or without adjusting for age, gender, body mass index, neck circumference, waist circumference and waist-to-hip ratio.	Oxygen	182-188	secreted frizzled related protein 5	Homo sapiens	13-48
31804046-1	2019	BACKGROUND/AIMS: We have previously shown that inhibition of the mitochondrial Kv1.3 channel results in an initial mitochondrial hyperpolarization and a release of oxygen radicals that mediate mitochondrial depolarization, cytochrome c release and death.	Oxygen	164-170	cytochrome c, somatic	Homo sapiens	223-235
31096895-5	2019	Particularly, oxygen-sensing pathways (e.g. hypoxia inducible factor, HIF1), are critical for adaptation to changes in oxygen availability in diseases such as myocardial ischemia.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-74
31096895-5	2019	Particularly, oxygen-sensing pathways (e.g. hypoxia inducible factor, HIF1), are critical for adaptation to changes in oxygen availability in diseases such as myocardial ischemia.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-74
31096895-8	2019	This review addresses our current understanding of the connection between light-sensing pathways (PER2), and oxygen-sensing pathways (HIF1A), in the context of myocardial ischemia and lays the groundwork for future studies to take advantage of these two evolutionarily conserved pathways in the treatment of myocardial ischemia.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
31486323-0	2019	C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1alpha through the Oxygen-Dependent Degradation Pathway.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
31486323-12	2019	Surprisingly, we found that when the C-terminal of HSP90 is inhibited, HIF-1alpha degradation occurs through the proteasome and prolyl hydroxylases in an oxygen-dependent manner even in very low levels of oxygen (tumor hypoxia levels).	Oxygen	154-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
31486323-12	2019	Surprisingly, we found that when the C-terminal of HSP90 is inhibited, HIF-1alpha degradation occurs through the proteasome and prolyl hydroxylases in an oxygen-dependent manner even in very low levels of oxygen (tumor hypoxia levels).	Oxygen	205-211	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
29943700-4	2019	Clinical and animal experiments reveal that age-related bone loss is associated with many factors such as accumulation of autophagy, increased levels of reactive oxygen species, sex hormone deficiency, and high levels of endogenous glucocorticoids.	Oxygen	162-168	renin binding protein	Homo sapiens	44-47
31339071-0	2019	Inhibition of Histone Deacetylase 6 Protects Hippocampal Cells Against Mitochondria-mediated Apoptosis in a Model of Severe Oxygen-glucose Deprivation.	Oxygen	124-130	histone deacetylase 6	Mus musculus	14-35
30843002-16	2019	Secondary polycythemia occurs in response to decreased oxygen intake, often as a result of smoking, which results in increased erythropoietin and hematocrit levels.	Oxygen	55-61	erythropoietin	Homo sapiens	127-141
31695223-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	4-31
31695223-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	33-37
31695223-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	122-126
31695223-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	157-161
32091028-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	4-31
32091028-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	33-37
32091028-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	122-126
32091028-1	2019	The superoxide dismutase type 1 (SOD1) gene is the first responsible gene mapped in amyotrophic lateral sclerosis type 1 (ALS1), and it codes for the enzyme SOD1, the function of which is to protect against damage mediated by free radicals deriving from oxygen.	Oxygen	254-260	superoxide dismutase 1	Homo sapiens	157-161
30255592-14	2019	Oxygen tension may profoundly and differentially influence inflammation-associated cartilage injury and diseases by regulating the expression of HIF1alpha and HIF2alpha.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	145-154
31640091-6	2019	It specifically proposes that during oxygen limitation, Abeta selectively inactivates ETC complexes in mitochondria that exhibit relatively low absolute values of Psim, thereby suppressing oxygen binding and consumption by complex IV of the ETC in these mitochondria.	Oxygen	37-43	amyloid beta precursor protein	Homo sapiens	56-61
31640091-6	2019	It specifically proposes that during oxygen limitation, Abeta selectively inactivates ETC complexes in mitochondria that exhibit relatively low absolute values of Psim, thereby suppressing oxygen binding and consumption by complex IV of the ETC in these mitochondria.	Oxygen	189-195	amyloid beta precursor protein	Homo sapiens	56-61
31640091-7	2019	This effect of Abeta on low-Psim mitochondria is hypothesized to spare hypoxia-limited oxygen for oxphos-enabling utilization by the ETC of the remaining active, higher-Psim local mitochondria, and thereby to increase overall ATP generated collectively by the local mitochondrial population, i.e., to ameliorate hypoxia-induced oxphos reduction.	Oxygen	87-93	amyloid beta precursor protein	Homo sapiens	15-20
31003581-4	2019	The oxygen-limiting zone (dissolved oxygen = 0.5-1.5 mg L-1), where nitrite-oxidizing activity has been suggested to be suppressed and ammonia-oxidizing activity was reported to be maintained, occurred at 10-230 microm from the gel matrices surface.	Oxygen	4-10	immunoglobulin kappa variable 1-16	Homo sapiens	56-59
30522768-0	2019	Arterial oxygen content regulates plasma erythropoietin independent of arterial oxygen tension: a blinded crossover study.	Oxygen	9-15	erythropoietin	Homo sapiens	41-55
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	68-74	erythropoietin	Homo sapiens	18-32
30606417-2	2019	Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension.	Oxygen	94-100	erythropoietin	Homo sapiens	50-64
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	68-74	erythropoietin	Homo sapiens	34-37
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	128-134	erythropoietin	Homo sapiens	18-32
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	128-134	erythropoietin	Homo sapiens	34-37
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	128-134	erythropoietin	Homo sapiens	18-32
30522768-1	2019	The production of erythropoietin (Epo) is modulated by renal tissue oxygen tension, which in principle depends on both arterial oxygen content (CaO2) and arterial oxygen tension (PaO2).	Oxygen	128-134	erythropoietin	Homo sapiens	34-37
31262220-5	2019	Remarkably, upon treatment with the flg22, elf18 and pep1 PAMP/DAMPs, BSK5-overexpressing plants displayed higher levels of immune responses, including production of reactive oxygen species, callose deposition at the cell wall, and PATHOGENESIS-RELATED1 (PR1) gene expression.	Oxygen	175-181	kinase with tetratricopeptide repeat domain-containing protein	Arabidopsis thaliana	70-74
31727237-2	2019	The P2X7R is an extracellular ATP-gated ion channel with peculiar permeability properties expressed by most cell types, mainly in the immune system, where it has a leading role in cytokine release, oxygen radical generation, T lymphocyte differentiation and proliferation.	Oxygen	198-204	purinergic receptor P2X 7	Homo sapiens	4-9
31382832-0	2019	Hyperbaric oxygen promotes mitophagy by activating CaMKKbeta/AMPK signal pathway in rats of neuropathic pain.	Oxygen	11-17	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	61-65
31815118-2	2019	Key transcription factors that recognize xenobiotics or xenobiotic-induced stress such as reactive oxygen species (ROS), include AhR, PXR, CAR, MTF, Nrf2, NF-kappaB, and AP-1.	Oxygen	99-105	nuclear receptor subfamily 1 group I member 2	Homo sapiens	134-137
30712667-1	2019	INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1).	Oxygen	52-58	vascular endothelial growth factor A	Homo sapiens	118-154
30712667-1	2019	INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1).	Oxygen	52-58	vascular endothelial growth factor A	Homo sapiens	156-161
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	vascular endothelial growth factor A	Homo sapiens	57-62
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	placental growth factor	Homo sapiens	77-100
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	placental growth factor	Homo sapiens	102-105
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	vascular endothelial growth factor A	Homo sapiens	116-121
31683367-7	2019	Isolated VGE usually requires no treatment; AGE treatment is similar to decompression sickness (DCS), with first aid oxygen then hyperbaric oxygen.	Oxygen	117-123	renin binding protein	Homo sapiens	44-47
31672495-1	2019	AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-35
31672495-1	2019	AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
30290302-4	2019	No hydrogen peroxide accumulation was observed in DDC + HOCbl solutions; however, catalase slowed down the oxygen reduction rate.	Oxygen	107-113	catalase	Homo sapiens	82-90
30086098-0	2019	Reducing Proinflammatory Signaling and Enhancing Insulin Secretion With the Application of Oxygen Persufflation in Human Pancreata.	Oxygen	91-97	insulin	Homo sapiens	49-56
30095738-0	2019	Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.	Oxygen	0-6	insulin	Homo sapiens	61-68
30525478-6	2018	Thus, MSN-Ru is a promising molecular probe of oxygen levels in living cells and tissues.	Oxygen	47-53	moesin	Homo sapiens	6-9
30575721-1	2018	Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor.	Oxygen	66-72	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
30575721-1	2018	Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor.	Oxygen	66-72	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
30506081-0	2018	Boosting the triplet activity of heavy-atom-free difluoroboron dibenzoylmethane via sp3 oxygen-bridged electron donors.	Oxygen	88-94	Sp3 transcription factor	Homo sapiens	84-87
30506081-3	2018	Here we show that by simply introducing an sp3 oxygen-bridged methoxylphenyl group as a pendant to BF2dbm, the boron complex exhibits a triplet quantum yield of 0.16, a more than 100-fold increase compared to that of BF2dbm.	Oxygen	47-53	Sp3 transcription factor	Homo sapiens	43-46
30506081-3	2018	Here we show that by simply introducing an sp3 oxygen-bridged methoxylphenyl group as a pendant to BF2dbm, the boron complex exhibits a triplet quantum yield of 0.16, a more than 100-fold increase compared to that of BF2dbm.	Oxygen	47-53	forkhead box G1	Homo sapiens	99-102
30651902-10	2018	Moreover, intrathecal administration of 20 mug/mL oxygen/ozone reversed the increased levels of spinal PDE2A and NF-kappaB/p65 mRNA and protein expressions in rats with chronic radiculitis.	Oxygen	50-56	synaptotagmin 1	Rattus norvegicus	123-126
30403990-11	2018	This was associated by maladaptation of myosin heavy-chain isoforms and lower reactive oxygen scavenger enzymes induction in Cnr2-/--hearts.	Oxygen	87-93	cannabinoid receptor 2 (macrophage)	Mus musculus	125-129
30463908-7	2018	We identified MAPK kinase kinase 8 (MAP3K8) as a target gene of hypoxia-induced factor (HIF), a transcription factor controlled by oxygen tension, upstream of the p38/MAPK pathway.	Oxygen	131-137	mitogen-activated protein kinase 14	Homo sapiens	14-18
30463908-7	2018	We identified MAPK kinase kinase 8 (MAP3K8) as a target gene of hypoxia-induced factor (HIF), a transcription factor controlled by oxygen tension, upstream of the p38/MAPK pathway.	Oxygen	131-137	mitogen-activated protein kinase 14	Homo sapiens	163-166
30463908-7	2018	We identified MAPK kinase kinase 8 (MAP3K8) as a target gene of hypoxia-induced factor (HIF), a transcription factor controlled by oxygen tension, upstream of the p38/MAPK pathway.	Oxygen	131-137	mitogen-activated protein kinase 14	Homo sapiens	167-171
30549016-6	2018	The "critmeter" theory suggests that O2 sensors located within the juxtamedullary apparatus regulate the hematocrit via modulation of renal erythropoietin (EPO) production according to arterial O2 content-dependent changes in tissue O2 pressure.	Oxygen	37-39	erythropoietin	Homo sapiens	140-154
30549016-6	2018	The "critmeter" theory suggests that O2 sensors located within the juxtamedullary apparatus regulate the hematocrit via modulation of renal erythropoietin (EPO) production according to arterial O2 content-dependent changes in tissue O2 pressure.	Oxygen	37-39	erythropoietin	Homo sapiens	156-159
30549016-6	2018	The "critmeter" theory suggests that O2 sensors located within the juxtamedullary apparatus regulate the hematocrit via modulation of renal erythropoietin (EPO) production according to arterial O2 content-dependent changes in tissue O2 pressure.	Oxygen	194-196	erythropoietin	Homo sapiens	140-154
30549016-6	2018	The "critmeter" theory suggests that O2 sensors located within the juxtamedullary apparatus regulate the hematocrit via modulation of renal erythropoietin (EPO) production according to arterial O2 content-dependent changes in tissue O2 pressure.	Oxygen	194-196	erythropoietin	Homo sapiens	140-154
30651902-0	2018	Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-kappaB/p65 Signaling in Chronic Radiculitis Rats.	Oxygen	18-24	synaptotagmin 1	Rattus norvegicus	119-122
30651902-8	2018	Intrathecal administration of 10 mug/mL, 20 mug/mL, or 30 mug/mL oxygen/ozone significantly attenuated the decreased mechanical PWTs, downregulated the overexpression of spinal TNF-alpha, IL-1beta, and IL-6, and increased the expression of cGMP and cAMP in chronic radiculitis rats.	Oxygen	65-71	tumor necrosis factor	Rattus norvegicus	177-186
30651902-8	2018	Intrathecal administration of 10 mug/mL, 20 mug/mL, or 30 mug/mL oxygen/ozone significantly attenuated the decreased mechanical PWTs, downregulated the overexpression of spinal TNF-alpha, IL-1beta, and IL-6, and increased the expression of cGMP and cAMP in chronic radiculitis rats.	Oxygen	65-71	interleukin 1 beta	Rattus norvegicus	188-196
30651902-8	2018	Intrathecal administration of 10 mug/mL, 20 mug/mL, or 30 mug/mL oxygen/ozone significantly attenuated the decreased mechanical PWTs, downregulated the overexpression of spinal TNF-alpha, IL-1beta, and IL-6, and increased the expression of cGMP and cAMP in chronic radiculitis rats.	Oxygen	65-71	interleukin 6	Rattus norvegicus	202-206
30651902-11	2018	Conclusion: Intrathecal administration of low-concentration oxygen/ozone alleviated mechanical allodynia and attenuated radiculitis, likely by a PDE2A-cGMP/cAMP-NF-kappaB/p65 signaling pathway in chronic radiculitis rats.	Oxygen	60-66	synaptotagmin 1	Rattus norvegicus	171-174
30347500-1	2018	Carbon bonds (C-bonds) are the highly directional noncovalent interactions between carbonyl-oxygen acceptors and sp3 -hybridized-carbon sigma-hole donors through n sigma* electron delocalization.	Oxygen	92-98	Sp3 transcription factor	Homo sapiens	113-116
29990903-12	2018	In the submerged area with limited oxygen, the microbial transformation of NO3- - N still occurred.	Oxygen	35-41	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30557110-3	2018	The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device.	Oxygen	71-77	microtubule affinity regulating kinase 1	Homo sapiens	13-17
30525843-0	2018	Oxygen pulse as a protective factor of insulin resistance in sedentary women with overweight or obesity.	Oxygen	0-6	insulin	Homo sapiens	39-46
30557110-3	2018	The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device.	Oxygen	121-127	microtubule affinity regulating kinase 1	Homo sapiens	13-17
30531464-1	2018	Frequent, low doses of recombinant human erythropoietin (rHuEpo) have been shown to increase the oxygen carrying capacity of an athlete and enhance endurance performance, although its effect on repeated sprint ability (RSA) remains unknown.	Oxygen	97-103	erythropoietin	Homo sapiens	41-55
30133321-12	2018	unc-51 mutants also had a proportionally smaller reduction in oxygen consumption rate during starvation, suggesting that autophagy also contributes to reduced mitochondrial function.	Oxygen	62-68	Serine/threonine-protein kinase unc-51	Caenorhabditis elegans	0-6
30372875-6	2018	Increased expression of caveolin-1 and tight junction protein ZO-1 were found in rats with hyperbaric oxygen exposure compared to those in IS group.	Oxygen	102-108	caveolin 1	Rattus norvegicus	24-34
30372875-7	2018	CONCLUSIONS: Hyperbaric oxygen exposure improved the permeability of the blood-brain barrier in rats with global cerebral ischemia/reperfusion injury, and increased expression of caveolin-1 and tight junction protein ZO-1 were involved in the mechanisms.	Oxygen	24-30	caveolin 1	Rattus norvegicus	179-189
29764240-1	2018	Iron or oxygen regulates the stability of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-73
30278417-7	2018	Collectively, our results indicate a cytosolic ROS overproduction, inducing oxidative damage and activating oxygen sensitive NRF2 and NF-kB signaling pathways for all the cell models acutely or repeatedly exposed to PM2.5.	Oxygen	108-114	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
30542494-3	2018	Hypoxia-inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional activator that drives the transcription of several immunosuppressive molecules.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
30542494-3	2018	Hypoxia-inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional activator that drives the transcription of several immunosuppressive molecules.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
29764240-1	2018	Iron or oxygen regulates the stability of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
30073566-0	2018	Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-kappaB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes.	Oxygen	11-17	nuclear factor kappa B subunit 1	Homo sapiens	92-101
30223019-5	2018	VAOS was further identified to induce NSCLC cell apoptosis through activating protein kinase B (AKT) to elevate intracellular reactive oxygen species (ROS) levels by increasing in oxygen consumption and impairing the ROS-scavenging system.	Oxygen	135-141	AKT serine/threonine kinase 1	Homo sapiens	96-99
30451174-2	2018	Its pathophysiology starts with decreased retinal oxygen tension that manifests as retinal capillary hyperpermeability and increased intravascular pressure mediated by vascular endothelial growth factor (VEGF) upregulation and retinal vascular autoregulation, respectively.	Oxygen	50-56	vascular endothelial growth factor A	Homo sapiens	168-202
30451174-2	2018	Its pathophysiology starts with decreased retinal oxygen tension that manifests as retinal capillary hyperpermeability and increased intravascular pressure mediated by vascular endothelial growth factor (VEGF) upregulation and retinal vascular autoregulation, respectively.	Oxygen	50-56	vascular endothelial growth factor A	Homo sapiens	204-208
30381478-6	2018	We now report that exposure of primary murine AEC to hypoxia (1% oxygen) for 24 h results in significant suppression of key innate immune molecules, including GM-CSF, CCL2, and IL-6.	Oxygen	65-71	interleukin 6	Mus musculus	177-181
30359537-0	2018	Long-term effects of NO3- on the relationship between oxygen uptake and power after three weeks of supplemented HIHVT.	Oxygen	54-60	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
30359537-1	2018	The aim of this study was to investigate the later effects of daily NO3- supplementation over 3 wk of training on the relationship between O2 uptake and power at different intensities with an incremental test (IT), a double-wingate test (WT), and an endurance capacity test at 80% Wmax (ECT) before and after the supplementation period.	Oxygen	139-141	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
30307701-5	2018	Furthermore, utilizing the ability of TAM in reducing the oxygen consumption of cancer cells, it is found that HSA-Ce6/TAM after systemic administration could efficiently attenuate the tumor hypoxia status.	Oxygen	58-64	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	38-41
30353303-12	2018	SNPs and expression of ARSB are associated with response to long-term oxygen in COPD.	Oxygen	70-76	arylsulfatase B	Mus musculus	23-27
30353303-13	2018	The ARSB SNPs were expression quantitative trait loci depending on oxygen therapy.	Oxygen	67-73	arylsulfatase B	Mus musculus	4-8
29052437-3	2018	The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis.	Oxygen	96-102	vascular endothelial growth factor A	Homo sapiens	18-22
30054562-10	2018	Accordingly, CAB39L reversed the Warburg effect in GC, as evidenced by enhanced oxygen consumption rate and reduced extracellular acidification rate; inversely, CAB39L knockdown promoted a metabolic shift towards the Warburg phenotype.	Oxygen	80-86	calcium binding protein 39 like	Homo sapiens	13-19
30898982-2	2018	Diminished O2 saturation which is related to elevated level of hypoxia inducible factor 1 (HIF-1) transcription factor, may switch the expression of many genes.	Oxygen	11-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-89
30898982-2	2018	Diminished O2 saturation which is related to elevated level of hypoxia inducible factor 1 (HIF-1) transcription factor, may switch the expression of many genes.	Oxygen	11-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
30031069-2	2018	Hif-1alpha is only stabilised under low oxygen levels, and the in vivo stabilisation of this factor in neural crest cells is poorly understood.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha a	Danio rerio	0-10
30031069-3	2018	Multiple oxygen-independent Hif-1alpha regulators have been described in cell cultures and cancer models.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha a	Danio rerio	28-38
30415294-7	2018	Cell culture in 0.2% O2 induced expression of NLRP3 and pro-IL-1beta genes but not of the pro-IL-18 gene.	Oxygen	21-23	NLR family pyrin domain containing 3	Homo sapiens	46-51
30415294-7	2018	Cell culture in 0.2% O2 induced expression of NLRP3 and pro-IL-1beta genes but not of the pro-IL-18 gene.	Oxygen	21-23	interleukin 1 beta	Homo sapiens	56-68
30307701-5	2018	Furthermore, utilizing the ability of TAM in reducing the oxygen consumption of cancer cells, it is found that HSA-Ce6/TAM after systemic administration could efficiently attenuate the tumor hypoxia status.	Oxygen	58-64	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	111-122
30282042-12	2018	This study suggests that introduction of an oxygen to compensate for the N+ - charge could be a useful strategy for reducing hERG potency and increasing the safety margin of alkaloid-type compounds in drug development.	Oxygen	44-50	ETS transcription factor ERG	Homo sapiens	125-129
30282042-0	2018	Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs.	Oxygen	70-76	ETS transcription factor ERG	Homo sapiens	11-15
30282042-8	2018	Compared to their parent compounds, only an oxygen atom was introduced in the nitrogen oxidative isoforms to compensate for the N+ - charge, suggesting that the protonated nitrogen is the key group for strychnine and brucine binding to hERG channel.	Oxygen	44-50	ETS transcription factor ERG	Homo sapiens	236-240
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Oxygen	17-23	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Oxygen	17-23	Src like adaptor	Homo sapiens	216-220
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Oxygen	17-23	NBL1, DAN family BMP antagonist	Homo sapiens	289-292
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Oxygen	62-68	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30515183-7	2018	The transcriptional expression of mll2707 and mlr0970 genes was analyzed under different oxygen growth conditions.	Oxygen	89-95	ubiquinol-cytochrome c reductase iron-sulfur subunit	Mesorhizobium japonicum MAFF 303099	34-41
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	interleukin 1 beta	Mus musculus	78-86
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	interleukin 6	Mus musculus	88-92
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	tumor necrosis factor	Mus musculus	104-113
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	autophagy related 7	Mus musculus	252-256
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	7-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-3	2018	Here we utilized a novel dianionic pentadentate ligand system that enabled a detailed mechanistic investigation of the protonation of a cobalt(III)-cobalt(III) peroxo dimer, a known intermediate in oxygen reduction catalysis to hydrogen peroxide.	Oxygen	198-204	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	143-146
30398331-3	2018	Here we utilized a novel dianionic pentadentate ligand system that enabled a detailed mechanistic investigation of the protonation of a cobalt(III)-cobalt(III) peroxo dimer, a known intermediate in oxygen reduction catalysis to hydrogen peroxide.	Oxygen	198-204	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	155-158
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	41-44	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	214-217
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	41-44	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-229
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	108-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	108-110	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	214-217
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	108-110	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-229
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	195-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	195-197	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	214-217
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	195-197	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-229
30568518-0	2018	Relationship between oxygen cost and C-reactive protein response to marathon running in college recreational runners.	Oxygen	21-27	C-reactive protein	Homo sapiens	37-55
30568518-10	2018	Spearman correlation analysis showed that the change in CRP level was significantly positively correlated with oxygen cost (r=0.619, P=0.011) but not maximal oxygen uptake.	Oxygen	111-117	C-reactive protein	Homo sapiens	56-59
30568518-10	2018	Spearman correlation analysis showed that the change in CRP level was significantly positively correlated with oxygen cost (r=0.619, P=0.011) but not maximal oxygen uptake.	Oxygen	158-164	C-reactive protein	Homo sapiens	56-59
30628229-5	2018	The average effluent concentrations of NH4+-N, NO2--N, and chemical oxygen demand (COD) were 2.14, 1.07, and 30.50 mg L-1, and their removal rates were 93.62%, 97.79%, and 74.75%, respectively.	Oxygen	68-74	immunoglobulin kappa variable 1-16	Homo sapiens	118-121
30451826-5	2018	Moreover, ER-resident Osm1 can transfer electrons from the Ero1 FAD cofactor to fumarate either by free FAD or by a direct interaction, allowing de novo disulfide bond formation in the absence of oxygen.	Oxygen	196-202	fumarate reductase	Saccharomyces cerevisiae S288C	22-26
30417421-3	2018	We revealed that Rab6A was induced by hypoxia (1% O2 ) and was involved in a hypoxia-induced phenotypic switch and endoplasmic reticulum stress (ERS) in RPASMCs.	Oxygen	50-52	RAB6A, member RAS oncogene family	Rattus norvegicus	17-22
30354247-7	2018	Cultured human brain endothelial cells subjected to oxygen-glucose deprivation and exposed to platelets from MBL-/- mice present less cell death and lower CXCL1 (chemokine [C-X-C motif] ligand 1) release (downstream to IL-1alpha) than those exposed to wild-type platelets.	Oxygen	52-58	chemokine (C-X-C motif) ligand 1	Mus musculus	155-160
30339375-7	2018	In the presence of O2, both 5 and 6 transform to nitrite-bound monomers [(LMe(S-S))Ni(NO2)](ClO4) (7) and [(LBr(S-S))Ni(NO2)](ClO4)2 (8).	Oxygen	19-21	lamin B receptor	Homo sapiens	108-111
30144273-3	2018	Different roles for the human HIF-1/2alpha isoforms and their two oxygen-dependent degradation domains (ODDs) are proposed.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-42
30346746-7	2018	Parallel enzymatic studies on the CDO variant C93G were carried out with the abt substrate and show that reaction with O2 leads to disulfide formation, as opposed to S-oxygenation.	Oxygen	119-121	cell adhesion associated, oncogene regulated	Homo sapiens	34-37
30809352-1	2019	A biomimetic study for S/Se oxygenation in Ni(mu-EPh)(mu-SN2)Fe, (E = S or Se; SN2 = Me-diazacycloheptane-CH2CH2S); Fe = (eta5-C5H5)FeII(CO) complexes related to the oxygen-damaged active sites of [NiFeS]/[NiFeSe]-H2ases is described.	Oxygen	28-34	solute carrier family 38 member 5	Homo sapiens	57-60
30809352-1	2019	A biomimetic study for S/Se oxygenation in Ni(mu-EPh)(mu-SN2)Fe, (E = S or Se; SN2 = Me-diazacycloheptane-CH2CH2S); Fe = (eta5-C5H5)FeII(CO) complexes related to the oxygen-damaged active sites of [NiFeS]/[NiFeSe]-H2ases is described.	Oxygen	28-34	solute carrier family 38 member 5	Homo sapiens	79-82
30809352-4	2019	Computational studies (DFT) found that the lowest energy isomers of mono-oxygen derivatives of Ni(mu-EPh)(mu-SN2)Fe complexes were those with O attachment to Ni rather than Fe, a result consonant with experimental findings, but at odds with oxygenates found in oxygen-damaged [NiFeS]/[NiFeSe]-H2ase structures.	Oxygen	73-79	solute carrier family 38 member 5	Homo sapiens	109-112
30809352-4	2019	Computational studies (DFT) found that the lowest energy isomers of mono-oxygen derivatives of Ni(mu-EPh)(mu-SN2)Fe complexes were those with O attachment to Ni rather than Fe, a result consonant with experimental findings, but at odds with oxygenates found in oxygen-damaged [NiFeS]/[NiFeSe]-H2ase structures.	Oxygen	241-247	solute carrier family 38 member 5	Homo sapiens	109-112
30354155-0	2018	Visible-Light- and Oxygen-Promoted Direct Csp2-H Radical Difluoromethylation of Coumarins and Antifungal Activities.	Oxygen	19-25	regulator of calcineurin 2	Homo sapiens	42-46
29894205-10	2018	In newborn mice, MV with air or 40% O2 inhibited EGFR phosphorylation and suppressed Klf4 protein content in lungs (vs. unventilated controls), yielding increased apoptosis.	Oxygen	36-38	Kruppel-like factor 4 (gut)	Mus musculus	85-89
30354247-7	2018	Cultured human brain endothelial cells subjected to oxygen-glucose deprivation and exposed to platelets from MBL-/- mice present less cell death and lower CXCL1 (chemokine [C-X-C motif] ligand 1) release (downstream to IL-1alpha) than those exposed to wild-type platelets.	Oxygen	52-58	chemokine (C-X-C motif) ligand 1	Mus musculus	162-194
28825349-4	2018	The results showed that oxygen in the atmosphere was reduced to OH  on the GDE, where carbon black catalyzed oxygen reduction to H2O2 and graphene provide Pi-electrons for the following H2O2 decomposition.	Oxygen	24-30	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	75-78
29028939-2	2018	In the current report, blood oxygen level-dependent (BOLD) signal was collected during music listening in 25 healthy adults after administration of placebo, lysergic acid diethylamide (LSD), and LSD pretreated with the 5HT2A antagonist ketanserin, to investigate the role of 5HT2A receptor signaling in the neural response to the time-varying tonal structure of music.	Oxygen	29-35	5-hydroxytryptamine receptor 2A	Homo sapiens	219-224
29772209-5	2018	Prolyl hydroxylase 2 (PHD2) is a negative regulator of HIF-1alpha and causes degradation of HIF-1alpha in the presence of oxygen.	Oxygen	122-128	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-20
29772209-5	2018	Prolyl hydroxylase 2 (PHD2) is a negative regulator of HIF-1alpha and causes degradation of HIF-1alpha in the presence of oxygen.	Oxygen	122-128	egl-9 family hypoxia inducible factor 1	Homo sapiens	22-26
29772209-5	2018	Prolyl hydroxylase 2 (PHD2) is a negative regulator of HIF-1alpha and causes degradation of HIF-1alpha in the presence of oxygen.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
30203466-10	2018	The basal microvascular flow of patients with peak oxygen consumption below 16.0 mL kg-1 min-1 was superior to that of patients with values greater than 16.0 mL kg-1 min-1 (P = .0046).	Oxygen	51-57	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
30607738-3	2018	The functioning of xanthine oxidase from milk along with the two-electron reduction of O2 to H2O2 carries through the one-electron reduction of O2 to [Formula: see text], and the rate and the fraction of generation of [Formula: see text] increased with increasing pH.	Oxygen	87-89	Weaning weight-maternal milk	Bos taurus	41-45
30607738-3	2018	The functioning of xanthine oxidase from milk along with the two-electron reduction of O2 to H2O2 carries through the one-electron reduction of O2 to [Formula: see text], and the rate and the fraction of generation of [Formula: see text] increased with increasing pH.	Oxygen	95-97	Weaning weight-maternal milk	Bos taurus	41-45
30143543-3	2018	Here, we used SILAC-based proteomics to identify the orphan G protein-coupled receptor GPRC5A as a novel hypoxia-induced protein that functions to protect cancer cells from apoptosis during oxygen deprivation.	Oxygen	190-196	G protein-coupled receptor class C group 5 member A	Homo sapiens	87-93
28825349-4	2018	The results showed that oxygen in the atmosphere was reduced to OH  on the GDE, where carbon black catalyzed oxygen reduction to H2O2 and graphene provide Pi-electrons for the following H2O2 decomposition.	Oxygen	109-115	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	75-78
31949608-7	2018	Further study found that aconitine activated the production of reactive oxygen species, leading to an increased release of cytochrome c from mitochondria and the activation of apoptosis.	Oxygen	72-78	cytochrome c, somatic	Homo sapiens	123-135
30468455-0	2018	Autologous oxygen release nano bionic scaffold composite miR-106a induced BMSCs enhances osteoblast conversion and promotes bone repair through regulating BMP-2.	Oxygen	11-17	microRNA 106a	Rattus norvegicus	57-65
30468455-4	2018	We intend to investigate the role of autologous oxygen release nano bionic scaffold composite miR-106a in inducing BMSCs constructing tissue engineering bone.	Oxygen	48-54	microRNA 106a	Rattus norvegicus	94-102
30468455-12	2018	Autologous oxygen release nano bionic scaffold composite miR-106a induced BMSCs exhibited more significant effect on bone repair (p&lt;0.05).	Oxygen	11-17	microRNA 106a	Rattus norvegicus	57-65
30468455-13	2018	CONCLUSIONS: Autologous oxygen release nano bionic scaffold composite miR-106a induced BMSCs enhanced osteoblast conversion and promoted bone repair through regulating BMP-2.	Oxygen	24-30	microRNA 106a	Rattus norvegicus	70-78
30255553-5	2018	Patients with peak oxygen uptake of &lt;13.1 ml O2  kg-1  min-1 and ventilatory equivalent for carbon dioxide at anaerobic threshold &gt;=34 are associated with increased risk of postoperative mortality at 2 years.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
30255553-5	2018	Patients with peak oxygen uptake of &lt;13.1 ml O2  kg-1  min-1 and ventilatory equivalent for carbon dioxide at anaerobic threshold &gt;=34 are associated with increased risk of postoperative mortality at 2 years.	Oxygen	48-50	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
30539720-13	2018	CONCLUSIONS: Oxygen may regulate AQP4 expression in human placenta, possibly through HIF-1alpha.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
30351095-4	2018	In contrast, the azide splits off N2 and furnishes a transient triplet sulfonyl nitrene intermediate (OCN)S(O)2N upon a 266 nm laser irradiation in solid Ne-matrix at 2.8 K. Subsequent photolysis of the nitrene with visible light (lambda = 380-450 nm) results in oxygen-shifted Curtius rearrangement to a novel nitroso sulfoxide (OCN)S(O)NO.	Oxygen	263-269	bone gamma-carboxyglutamate protein	Homo sapiens	102-105
30115664-7	2018	In order to address potential acquired resistance mechanisms to MCT1 inhibition, we generated MCT1 inhibitor-resistant cell lines and show that resistance can occur by upregulation of MCT4 even in the presence of sufficient oxygen, as well as by shifting energy generation toward oxidative phosphorylation.	Oxygen	224-230	solute carrier family 16 member 1	Homo sapiens	94-98
30127511-2	2018	Here we describe the design and construction of catalase-containing organoclay/DNA semipermeable microcapsules, which in the presence of hydrogen peroxide exhibit enzyme-powered oxygen gas bubble-dependent buoyancy.	Oxygen	178-184	catalase	Homo sapiens	48-56
30533532-3	2018	Factors that regulate these developmental processes include vascular endothelial growth factor and matrix metalloproteinases, both of which are influenced by generation of oxygen byproducts, or reactive oxygen species (ROS).	Oxygen	172-178	vascular endothelial growth factor A	Homo sapiens	60-94
30130256-1	2018	Renin cells are crucial for survival - they control fluid-electrolyte and blood pressure homeostasis, vascular development, regeneration, and oxygen delivery to tissues.	Oxygen	142-148	renin	Homo sapiens	0-5
30409713-4	2018	OIR was induced in neonatal mice by exposure to 80% oxygen from postnatal day (P) 7 to P10 and to atmospheric oxygen from P10 to P15.	Oxygen	110-116	cyclin dependent kinase inhibitor 2B	Mus musculus	129-132
30382089-0	2018	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen.	Oxygen	75-81	epidermal growth factor receptor	Homo sapiens	20-24
30281275-3	2018	In this work, we studied proton and oxygen transport at the interface between H+-SOFC electrolyte BaCe xZr0.9- xY0.1O2.95 ( x = 0; 0.2; 0.9) thin films and the gas (100 mTorr of H2O and O2) by using synchrotron-based ambient pressure X-ray photoelectron spectroscopy at operating temperature (&gt;400  C).	Oxygen	36-42	beta-secretase 1	Homo sapiens	98-102
30281275-3	2018	In this work, we studied proton and oxygen transport at the interface between H+-SOFC electrolyte BaCe xZr0.9- xY0.1O2.95 ( x = 0; 0.2; 0.9) thin films and the gas (100 mTorr of H2O and O2) by using synchrotron-based ambient pressure X-ray photoelectron spectroscopy at operating temperature (&gt;400  C).	Oxygen	116-118	beta-secretase 1	Homo sapiens	98-102
30229749-8	2018	Insufficient oxygen and nutrient diffusion into the internal surface of lung scaffolds resulted in intracellular hypoxia, quantified by a significant upregulation of HIF-1alpha protein expression compared to that of cell monolayers.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
30425647-6	2018	In this context, the increase of oxygen and nitrogen reactive species could nitrate AQP9, producing the accumulation of a non-functional protein affecting the survival of the villous trophoblast (VT).	Oxygen	33-39	aquaporin 9	Homo sapiens	84-88
30373540-4	2018	METHODS: Hyperoxic ALI was induced in wild-type (WT) and IL-3 gene disrupted (IL-3-/-) mice by exposure to 100% O2 for 72 h. RESULTS: Hyperoxia increased IL-3 levels in plasma and lung tissues in WT mice.	Oxygen	112-114	interleukin 3	Mus musculus	57-61
30373540-5	2018	Pulmonary inflammation and edema were detected by histological assay in WT mice exposed to 100% O2 for 72 h. However, the hyperoxia-induced lung histological changes were improved in IL-3-/- mice.	Oxygen	96-98	interleukin 3	Mus musculus	183-187
30510589-0	2018	Oxygen Tension Strongly Influences Metabolic Parameters and the Release of Interleukin-6 of Human Amniotic Mesenchymal Stromal Cells In Vitro.	Oxygen	0-6	interleukin 6	Homo sapiens	75-88
30373276-10	2018	ApoE2 promoted neurite outgrowth after oxygen-glucose deprivation and axonal outgrowth of neurons, and increased proliferation/survival of OPCs derived from ABCA1-B/-B mice.	Oxygen	39-45	apolipoprotein E	Homo sapiens	0-5
30510589-8	2018	Furthermore, IL-6 was significantly increased at 20% oxygen.	Oxygen	53-59	interleukin 6	Homo sapiens	13-17
30510589-9	2018	To conclude, short-time cultivation at 20% oxygen of freshly isolated hAMSCs induced significant changes in mitochondrial function and release of IL-6.	Oxygen	43-49	interleukin 6	Homo sapiens	146-150
30402039-9	2018	Expression levels for Bcl-xL, caspase-9, receptor for advanced glycation end products (RAGE) and brain-derived neurotrophic factor (BDNF) were significantly different in quantification of band intensity between the rats that inhaled O2 and sevoflurane in Abeta-treated groups (all P &lt; 0.05).	Oxygen	233-235	advanced glycosylation end product-specific receptor	Rattus norvegicus	41-85
30241947-9	2018	We demonstrated that physiological temperature (37  C) and O2 supply were essential for the induction of IL-6 release from the incubated muscle, suggesting it is a controlled secretion rather than a spontaneous leak.	Oxygen	59-61	interleukin 6	Homo sapiens	105-109
30370249-7	2018	Cell lines grown in 5% oxygen showed increased expression of the hypoxia-inducible factor 1 (HIF-1) target gene carbonic anhydrase 9 (CA9) and decreased levels of ROS.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-91
30370249-7	2018	Cell lines grown in 5% oxygen showed increased expression of the hypoxia-inducible factor 1 (HIF-1) target gene carbonic anhydrase 9 (CA9) and decreased levels of ROS.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98
30364139-11	2018	In this review article, we describe and discuss the roles of Nrf2 in various iron-mediated bioreactions and its possible coevolution with iron and oxygen.	Oxygen	147-153	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
30245209-2	2018	To identify new druggable targets alternative to BCR/ABL, we investigated the role of the MEK5/ERK5 pathway in LSC maintenance in low oxygen, a feature of bone marrow stem cell niches.	Oxygen	134-140	mitogen-activated protein kinase kinase 5	Homo sapiens	90-94
29969687-1	2018	Cytoglobin is a widely expressed heme protein that binds oxygen, carbon monoxide and nitric oxide.	Oxygen	57-63	cytoglobin	Homo sapiens	0-10
30350781-6	2018	Further, the risk likelihood of apnea-related mortality associated with suppression of Pet1 neurons was higher for animals with baseline elevated ventilatory equivalents for oxygen.	Oxygen	174-180	plasmacytoma expressed transcript 1	Mus musculus	87-91
30158244-7	2018	Under hypoxia (1% oxygen), however, LDHA/B suppression completely abolished in vitro growth, consistent with the reliance on OXPHOS.	Oxygen	18-24	lactate dehydrogenase A	Homo sapiens	36-40
30305827-3	2018	In response to oxygen deprivation or hypoxia, one of the key response elements is hypoxia inducible factor (HIF) and a key protein induced by hypoxia is vascular endothelial growth factor (VEGF).	Oxygen	15-21	vascular endothelial growth factor A	Homo sapiens	153-187
30305827-3	2018	In response to oxygen deprivation or hypoxia, one of the key response elements is hypoxia inducible factor (HIF) and a key protein induced by hypoxia is vascular endothelial growth factor (VEGF).	Oxygen	15-21	vascular endothelial growth factor A	Homo sapiens	189-193
30195493-12	2018	When subjected for respirometry, PlGF-treated differentiated adipocytes showed higher oxygen consumption rates than controls.	Oxygen	86-92	placental growth factor	Homo sapiens	33-37
30286760-6	2018	RESULTS: Maximal oxygen uptake was 54.78 +- 3.13 mL min- 1 kg- 1, and gross efficiency was &gt; 22% at each load intensity and experimental condition.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	52-64
30241031-10	2018	Taken together, our results demonstrate that NRF2 targets a functional ARE at the HIF1A locus, and reveal a direct regulatory connection between two important oxygen responsive transcription factors.	Oxygen	159-165	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
30279167-4	2018	Spectral Doppler ultrasound revealed that deletion of the AMPK-alpha1 catalytic subunit blocked HPV in mice during mild (8% O2) and severe (5% O2) hypoxia, whereas AMPK-alpha2 deletion attenuated HPV only during severe hypoxia.	Oxygen	124-126	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	58-69
30279167-4	2018	Spectral Doppler ultrasound revealed that deletion of the AMPK-alpha1 catalytic subunit blocked HPV in mice during mild (8% O2) and severe (5% O2) hypoxia, whereas AMPK-alpha2 deletion attenuated HPV only during severe hypoxia.	Oxygen	143-145	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	58-69
30279167-7	2018	However, deletion of AMPK-alpha1, but not of AMPK-alpha2, blocked hypoxia from inhibiting KV1.5, the classical "oxygen-sensing" K+ channel in pulmonary arterial myocytes.	Oxygen	112-118	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	21-32
29933232-9	2018	The effect is less pronounced for the oxygen deficient MoO3 samples where cell viability does not fall below 85%.	Oxygen	38-44	modifier of obesity 3	Mus musculus	55-59
30124965-2	2018	We, therefore, developed the PARIS risk score based on blood pressure, age, respiratory rate, loss of independence and oxygen saturation.	Oxygen	119-125	zinc finger protein 746	Homo sapiens	29-34
29246449-7	2018	In this review we discuss who low fat mass and the resulting relative deficiencies in leptin and adiponectin could contribute to the increase frequency of oxygen desaturations that occurs days after birth in the smallest and youngest premature infants.	Oxygen	155-161	adiponectin, C1Q and collagen domain containing	Homo sapiens	97-108
30318520-0	2018	Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2-  production in cancer cells.	Oxygen	75-77	tumor protein p53	Homo sapiens	7-10
30318520-0	2018	Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2-  production in cancer cells.	Oxygen	75-77	PPARG coactivator 1 alpha	Homo sapiens	29-39
30154083-6	2018	We found activated, GITR-treated CD8+ T cells upregulated nutrient uptake, lipid stores, glycolysis, and oxygen consumption rate (OCR) in vitro Using MEK, PI3Kdelta, and metabolic inhibitors, we show increased metabolism is required, but not sufficient, for GITR antibody (DTA-1)-induced cellular proliferation and IFNgamma production.	Oxygen	105-111	tumor necrosis factor receptor superfamily, member 18	Mus musculus	20-24
30237125-0	2018	FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1alpha.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
30237125-7	2018	Since the FIH-dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
30148961-1	2018	FIH [factor inhibiting HIF (hypoxia inducible factor)] is an alpha-ketoglutarate (alphaKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the C-terminal transactivation domain (CAD) asparagine residue in HIF-1alpha to regulate cellular oxygen levels.	Oxygen	255-261	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-233
30355102-11	2018	Moreover, oxygen and glucose deprivation promoted MDM2 binding with p53 in neurons.	Oxygen	10-16	tumor protein p53	Homo sapiens	68-71
30355102-12	2018	Disruption of the MDM2-p53 interaction with nutlin-3a, or MDM2 knockdown by siRNA, triggered p53 accumulation, which increased neuronal susceptibility to oxygen and glucose deprivation-induced apoptosis.	Oxygen	154-160	tumor protein p53	Homo sapiens	23-26
30355102-12	2018	Disruption of the MDM2-p53 interaction with nutlin-3a, or MDM2 knockdown by siRNA, triggered p53 accumulation, which increased neuronal susceptibility to oxygen and glucose deprivation-induced apoptosis.	Oxygen	154-160	tumor protein p53	Homo sapiens	93-96
30274243-1	2018	Ion-molecule reaction between atomic oxygen anion (O-) and methane (CH4) has been systematically investigated employing the on-the-fly ab initio molecular dynamics simulations.	Oxygen	37-43	COP9 signalosome subunit 4	Drosophila melanogaster	68-71
30132477-1	2018	This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16-20 hours.	Oxygen	48-54	catalase	Homo sapiens	111-119
30132477-1	2018	This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16-20 hours.	Oxygen	145-151	catalase	Homo sapiens	111-119
30093113-0	2018	Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry.	Oxygen	29-35	coagulation factor II, thrombin	Homo sapiens	56-64
30093113-7	2018	We demonstrated a rapid, transient increase in oxygen consumption rate within minutes of platelet stimulation by the physiological activator, thrombin.	Oxygen	47-53	coagulation factor II, thrombin	Homo sapiens	142-150
30183273-5	2018	The most active catalyst was comprised of the m-PYA pincer ligand and PPh3, complex [Ru( m-PYA)(PPh3)(MeCN)2]2+, which reached a TOF50 of 430 h-1 under aerobic conditions and up to 4000 h-1 in the absence of oxygen.	Oxygen	208-214	caveolin 1	Homo sapiens	70-74
30219798-8	2018	Ex vivo, BNP attenuated oxygen-induced vasoconstriction of isolated DA rings of newborn rats.	Oxygen	24-30	natriuretic peptide B	Rattus norvegicus	9-12
30183273-5	2018	The most active catalyst was comprised of the m-PYA pincer ligand and PPh3, complex [Ru( m-PYA)(PPh3)(MeCN)2]2+, which reached a TOF50 of 430 h-1 under aerobic conditions and up to 4000 h-1 in the absence of oxygen.	Oxygen	208-214	caveolin 1	Homo sapiens	96-100
30223548-7	2018	We found that 4OH-PCB11 increased mitochondrial respiration and endogenous fatty-acid oxidation-associated oxygen consumption in SIRT3-knockout MEFs; this appeared to occur because the cells exhausted their reserve respiratory capacity.	Oxygen	107-113	sirtuin 3	Homo sapiens	129-134
30271757-4	2018	Persistent inflammation causes ongoing production of large quantities of pro-inflammatory cytokines and both oxygen and nitrogen reactive species, with consequent activation of transcription factor nuclear factor-kappa B (NF-kappaB) and genes encoding for further production of pro-inflammatory cytokines, chemotactic factors, and growth factors.	Oxygen	109-115	nuclear factor kappa B subunit 1	Homo sapiens	198-220
30271757-4	2018	Persistent inflammation causes ongoing production of large quantities of pro-inflammatory cytokines and both oxygen and nitrogen reactive species, with consequent activation of transcription factor nuclear factor-kappa B (NF-kappaB) and genes encoding for further production of pro-inflammatory cytokines, chemotactic factors, and growth factors.	Oxygen	109-115	nuclear factor kappa B subunit 1	Homo sapiens	222-231
30072100-5	2018	Our results showed that IDH2 downregulation led to mitochondrial dysfunction by decreasing the expression of mitochondrial oxidative phosphorylation complexes I, II, and IV, reducing oxygen consumption, and depolarizing mitochondrial membrane potential in human umbilical vein endothelial cells (HUVECs).	Oxygen	183-189	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	24-28
30216369-8	2018	It has been shown that PKM2 expression is regulated by HIF-1alpha and that PKM2 favors HIF-1alpha transactivation under mild (1% O2) but not severe (0.1% O2) hypoxic conditions, and some of our findings are consistent with these previous results.	Oxygen	129-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
30155529-1	2018	Based on the electronic properties of different hybridized oxygen atoms (sp3versus sp2) in the structure of O,O-acetals containing an enol ether moiety, the chemoselective formation of oxocarbenium ions was realized to furnish diversified chiral heterocyclic compounds with excellent stereoselectivities by reacting with different types of nucleophiles.	Oxygen	59-65	Sp2 transcription factor	Homo sapiens	83-86
29990814-4	2018	Firstly, the addition of EDDS could enhance hydroxyl radical generation by ZVI and oxygen for the oxidation of PCB including distribution in the soil phase and dissolved form in the aqueous phase.	Oxygen	83-89	pyruvate carboxylase	Homo sapiens	111-114
30212529-3	2018	The maximal oxygen uptake during running was higher (p = 0.001; large effect size) vs. cycling (49.2+-3.8 mL kg-1 min-1 vs. 44.7+-5.7 mL kg-1 min-1, respectively).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	114-119
30212529-3	2018	The maximal oxygen uptake during running was higher (p = 0.001; large effect size) vs. cycling (49.2+-3.8 mL kg-1 min-1 vs. 44.7+-5.7 mL kg-1 min-1, respectively).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
30213274-3	2018	FANCC is a predominantly cytoplasmic protein that has multiple functions including DNA damage signaling, oxygen radical metabolism, signal transduction, transcriptional regulation and apoptosis.	Oxygen	105-111	FA complementation group C	Homo sapiens	0-5
30245695-3	2018	The genesis of tissue edema is tightly linked to pathological changes in the endothelium: various reports demonstrated the effect of transforming growth factor beta, vascular endothelial growth factor and hypoxia-reperfusion damage with reactive oxygen species generation in altering vascular permeability and extravasation, in particular in SSc.	Oxygen	246-252	tumor necrosis factor	Homo sapiens	133-164
29931794-7	2018	A Rosetta docking model of CYP7B1 suggested that these substrates" D-ring hydroxy groups might prevent them from binding in the same way as the native substrates, bringing different carbon atoms close to the active ferryl oxygen atom.	Oxygen	222-228	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
29935187-3	2018	Our experimental results had shown that nuclear HIF-1alpha proteins were significantly induced after HepG2 cells treatment with 1% O2 for 6 h and reached the peak expression level in 24 h. Meanwhile, the results of RT-qPCR and Western-blotting showed that HIF-1alpha and cathepsin B (CTSB) expressions increased with a similar pattern in response to hypoxia in the HepG2 cells.	Oxygen	131-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
29935187-3	2018	Our experimental results had shown that nuclear HIF-1alpha proteins were significantly induced after HepG2 cells treatment with 1% O2 for 6 h and reached the peak expression level in 24 h. Meanwhile, the results of RT-qPCR and Western-blotting showed that HIF-1alpha and cathepsin B (CTSB) expressions increased with a similar pattern in response to hypoxia in the HepG2 cells.	Oxygen	131-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	256-266
29908183-0	2018	MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway.	Oxygen	21-27	AKT serine/threonine kinase 1	Homo sapiens	112-115
30153788-0	2018	Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.	Oxygen	65-71	MAX network transcriptional repressor	Homo sapiens	85-88
30323966-7	2018	Further, by inhibiting PDK4 expression, miR-211 promotes a phenotype shift towards a pro-glycolytic state evidenced by decreased extracellular acidification rate (ECAR); increased oxygen consumption rate (OCR); and increased spare respiratory capacity in breast cancer cell lines.	Oxygen	180-186	pyruvate dehydrogenase kinase 4	Homo sapiens	23-27
29857082-0	2018	Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression.	Oxygen	67-73	serpin family A member 1	Homo sapiens	6-25
29857082-4	2018	This study aimed to test whether hAAT can protect different kind of neurons and glial cells after the oxygen and glucose deprivation (OGD).	Oxygen	102-108	serpin family A member 1	Homo sapiens	33-37
29908837-1	2018	Hypoxia inducible factor-1 (HIF-1) supports survival of normal cells under low oxygen concentration and cancer cells in the hypoxic tumor microenvironment.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
29908837-1	2018	Hypoxia inducible factor-1 (HIF-1) supports survival of normal cells under low oxygen concentration and cancer cells in the hypoxic tumor microenvironment.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
29908837-8	2018	In conclusion, our findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions.	Oxygen	350-356	hypoxia inducible factor 1 subunit alpha	Homo sapiens	211-216
29908837-8	2018	In conclusion, our findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions.	Oxygen	350-356	hypoxia inducible factor 1 subunit alpha	Homo sapiens	267-272
29753286-2	2018	Coagulation with polyferric sulfate at a dosage of 1.5 g L-1 and a pH of 8.0 was effective, with color and chemical oxygen demand (COD) removal rates of 96.8 and 83.4%, respectively.	Oxygen	116-122	immunoglobulin kappa variable 1-16	Homo sapiens	57-60
30271595-8	2018	After 6 days in 4 C, the IL6-/- mice exhibited significantly lower body temperature and oxygen consumption compared with Wt mice (P&lt;0.05).	Oxygen	88-94	interleukin 6	Mus musculus	25-28
30153789-0	2018	Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.	Oxygen	65-71	MAX network transcriptional repressor	Homo sapiens	85-88
29945023-5	2018	PSG and 1-PSG proved to be stable in biological medium in the presence of atmospheric oxygen for several days.	Oxygen	86-92	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
29601782-6	2018	By using the noninvasive bioluminescence imaging ROSA26 oxygen-dependent domain Luc mouse model, we reveal that exercise increases in vivo HIFalpha levels in the liver.	Oxygen	56-62	gene trap ROSA 26, Philippe Soriano	Mus musculus	49-55
29887450-9	2018	Moreover, when we knocked down PGC1alpha, the mitochondrial maximal oxygen consumption and ATP levels enhanced by overexpression of UIHTC were nearly completely restored.	Oxygen	68-74	PPARG coactivator 1 alpha	Rattus norvegicus	31-40
30015875-6	2018	Secondly, the stable overexpression of Bcl-2 and ability to shift metabolism towards oxidative phosphorylation (OXPHOS) in SKOV3/DDP cells were associated with increased oxygen consumption.	Oxygen	170-176	BCL2 apoptosis regulator	Homo sapiens	39-44
29663377-0	2018	UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.	Oxygen	24-30	thymoma viral proto-oncogene 1	Mus musculus	123-126
29786753-8	2018	Furthermore, synthetic siRNA specific for HIF-1alpha significantly suppressed the expression of CXCR4 in JEG3 cells exposed to 3% O2, whereas pcDNA-HIF-1alpha significantly increased the expression of CXCR4.	Oxygen	130-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
29945023-5	2018	PSG and 1-PSG proved to be stable in biological medium in the presence of atmospheric oxygen for several days.	Oxygen	86-92	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	10-13
30015931-7	2018	The present study also detected the expression of HTRA1 and HTRA4 in HTR-8/SVneo transfected cells under hypoxia (1% O2) and further studied the effects of hypoxia on HTR-8 cell migration.	Oxygen	117-119	telomerase RNA component	Homo sapiens	50-53
29808231-8	2018	cUMP forms one hydrogen bond with PDE3B (uracil 3-NH with side chain oxygen of Q988).	Oxygen	69-75	phosphodiesterase 3B	Rattus norvegicus	34-39
30060096-4	2018	The expression of genes encoding prorenin (REN), angiotensinogen, (pro)renin receptor, angiotensin converting enzyme 2, and the angiotensin II type 1 receptor are highest in early gestation, at a time when oxygen tension is at its lowest.	Oxygen	206-212	renin	Homo sapiens	43-46
29862666-10	2018	Lower nadir oxygen saturation was associated with higher levels of tonsil TNF-alpha (P &lt; 0.001) and IL-10 (P &lt; 0.05).	Oxygen	12-18	tumor necrosis factor	Homo sapiens	74-83
30344587-8	2018	The partial pressure of blood oxygen was in a negative correlation with myocardial enzymes, hepatic and renal function and cTnT in the severe pneumonia group.	Oxygen	30-36	troponin T2, cardiac type	Homo sapiens	123-127
29726060-2	2018	However, various compounds can also stabilize HIF"s oxygen-responsive element, HIF-1alpha, at normoxia and mimic many hypoxia-induced cellular responses.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	87-89	Nanog homeobox	Mus musculus	45-50
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	113-115	Nanog homeobox	Mus musculus	45-50
29953346-7	2018	The oxygen enhancement ratio for double-strand break induction was 3.0 for low-LET radiation up to approximately 15 keV/mum, after which it gradually decreased to a value of 1.3 at 150 keV/mum.	Oxygen	4-10	latexin	Homo sapiens	120-123
29953346-7	2018	The oxygen enhancement ratio for double-strand break induction was 3.0 for low-LET radiation up to approximately 15 keV/mum, after which it gradually decreased to a value of 1.3 at 150 keV/mum.	Oxygen	4-10	latexin	Homo sapiens	189-192
30005164-2	2018	In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds to develop a hybrid protein oxygen nanocarrier with chlorine e6 encapsulated (C@HPOC) for oxygen self-sufficient photodynamic therapy (PDT).	Oxygen	128-134	albumin	Homo sapiens	21-34
30091518-5	2018	Biotinylated polymer vesicles that encapsulate catalase, an enzyme which converts hydrogen peroxide to water and oxygen, are prepared and these vesicles are adhered weakly to avidin-coated surfaces.	Oxygen	113-119	catalase	Homo sapiens	47-55
29887347-8	2018	Estimated oxygen consumption was highest during ingress hikes and was significantly different from all other hike types on fire assignments (ingress: 22+-12, shift: 19+-12, egress: 19+-12 mL kg-1 min-1; P=0.01).	Oxygen	10-16	CD59 molecule (CD59 blood group)	Homo sapiens	196-201
29887347-9	2018	Oxygen consumption was higher during training hikes (34+-14 mL kg-1 min-1) than during job-related hikes (P&lt;0.01).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
30060652-7	2018	Computational studies show that protonation is strongly favored at the proximal oxygen of the CoIII(OOH) species, accounting for the high selectivity for formation of hydrogen peroxide.	Oxygen	80-86	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	94-99
30060652-8	2018	Further analysis shows that a weak dependence of the ORR rate on the p Ka values of the protonated CoIII(OOH) species across a series of Co(N2O2) catalysts provides a rationale for the unusually low overpotential observed for O2 reduction to H2O2.	Oxygen	142-144	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	99-104
30197470-0	2018	Unveiling the Outstanding Oxygen Mass Transport Properties of Mn-Rich Perovskites in Grain Boundary-Dominated La0.8Sr0.2(Mn1-x Co x )0.85O3+-delta Nanostructures.	Oxygen	26-32	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	121-124
30197470-4	2018	Here, we fabricate a thin film continuous composition map of the La0.8Sr0.2(Mn1-x Co x )0.85O3+-delta family revealing a substantial enhancement of the grain boundary oxygen mass transport properties for the entire range of compositions.	Oxygen	167-173	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	76-79
30005164-2	2018	In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds to develop a hybrid protein oxygen nanocarrier with chlorine e6 encapsulated (C@HPOC) for oxygen self-sufficient photodynamic therapy (PDT).	Oxygen	190-196	albumin	Homo sapiens	21-34
30150707-4	2018	Here we show that abnormal, alpha-SMA-expressing pericytes cover angiogenic sprouts and pathological neovascular tufts (NVTs) in a mouse model of oxygen-induced retinopathy.	Oxygen	146-152	actin alpha 2, smooth muscle, aorta	Mus musculus	28-37
30153269-5	2018	Moreover, HIF-1alpha was stabilized in a proline hydroxylase-dependent manner by transient induction of intracellular hypoxia via the PGC-1alpha/ERRalpha-induced increases in mitochondrial biogenesis and oxygen consumption.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
30153269-5	2018	Moreover, HIF-1alpha was stabilized in a proline hydroxylase-dependent manner by transient induction of intracellular hypoxia via the PGC-1alpha/ERRalpha-induced increases in mitochondrial biogenesis and oxygen consumption.	Oxygen	204-210	PPARG coactivator 1 alpha	Homo sapiens	134-144
30153269-5	2018	Moreover, HIF-1alpha was stabilized in a proline hydroxylase-dependent manner by transient induction of intracellular hypoxia via the PGC-1alpha/ERRalpha-induced increases in mitochondrial biogenesis and oxygen consumption.	Oxygen	204-210	estrogen related receptor alpha	Homo sapiens	145-153
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Oxygen	216-222	estrogen related receptor alpha	Homo sapiens	131-139
30079408-2	2018	The inherent photochemical reactivity of the uranyl dication mediates the transformation of cage-1 to cage-2via the activation of molecular oxygen.	Oxygen	140-146	cancer antigen 1	Homo sapiens	92-98
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Oxygen	75-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-46
30114262-8	2018	High CRP levels were associated with younger age, higher body mass index (BMI), chronic obstructive pulmonary disease (COPD), lower peak oxygen consumption and higher endothelin-1 and aldosterone levels.	Oxygen	137-143	C-reactive protein	Homo sapiens	5-8
29631220-7	2018	Based on the structural results we propose a stoichiometry of the surface complexation reaction of Pb(II) on the hematite (11 02) surface and use bond valence analysis to assign the protonation schemes of surface oxygens.	Oxygen	213-220	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
29803741-0	2018	Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.	Oxygen	92-98	activating transcription factor 4	Mus musculus	84-88
30158902-8	2018	Diabetes impairs HIF-1 activation and thus, compromises HIF-1 mediated responses under oxygen-limited conditions.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
29641235-2	2018	Adrenergically stimulated sodium-proton exchangers (beta-NHE) create H+ gradients across the red blood cell (RBC) membrane that are short-circuited in the presence of plasma-accessible carbonic anhydrase (paCA) at the tissues; the result is a large arterial-venous pH shift that greatly enhances O2 unloading from pH-sensitive Hb.	Oxygen	296-298	Na(+)/H(+) exchanger beta	Oncorhynchus mykiss	52-60
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Oxygen	152-158	proline rich protein gene cluster	Homo sapiens	65-68
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Oxygen	203-209	proline rich protein gene cluster	Homo sapiens	65-68
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Oxygen	203-209	proline rich protein gene cluster	Homo sapiens	65-68
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Oxygen	203-209	proline rich protein gene cluster	Homo sapiens	65-68
29763796-6	2018	Based on column evaluations, more than 93% of chemical oxygen demand (influent concentration of 658 +- 19 mg L-1) could be removed microbially under flow conditions, when the hydraulic retention time was 45 h. Raw hematite-based Fe(III) bio-reduction has a promising potential for the removal of humic and benzene series in humified landfill leachate.	Oxygen	55-61	immunoglobulin kappa variable 1-16	Homo sapiens	109-112
30124647-1	2018	Low oxygen levels (hypoxia) trigger a variety of adaptive responses with the Hypoxia-inducible factor 1 (HIF-1) complex acting as a master regulator.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-103
30124647-1	2018	Low oxygen levels (hypoxia) trigger a variety of adaptive responses with the Hypoxia-inducible factor 1 (HIF-1) complex acting as a master regulator.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
30033085-3	2018	Using a human induced pluripotent stem cell-derived liver bud (hiPSC-LB) model, we found hypoxia induced with an O2-permeable plate promoted hepatic differentiation accompanied by TGFB1 and TGFB3 suppression.	Oxygen	113-115	transforming growth factor beta 1	Homo sapiens	180-185
30135282-9	2018	The data obtained suggest that if the oxygen supply of the organism is impaired, the endothelial nitric oxide synthase G894T polymorphism may be important for the oxidative stress development.	Oxygen	38-44	nitric oxide synthase 3	Homo sapiens	85-118
29930174-4	2018	LIMD1 complexes with PHD2 and VHL in physiological oxygen levels (normoxia) to facilitate proteasomal degradation of the HIF-alpha subunit.	Oxygen	51-57	LIM domain containing 1	Homo sapiens	0-5
29679130-3	2018	Aerated/non-aerated periods varied in the range of 2/1-1/3 h. The chemical oxygen demand (COD) in the effluent remained between 26 and 42 mg L-1 throughout all the aeration conditions.	Oxygen	75-81	immunoglobulin kappa variable 1-16	Homo sapiens	141-144
29704240-6	2018	As the O2 -supply capacity was systematically lowered, O2 respiration was gradually replaced by NO3- respiration.	Oxygen	7-9	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
29930174-4	2018	LIMD1 complexes with PHD2 and VHL in physiological oxygen levels (normoxia) to facilitate proteasomal degradation of the HIF-alpha subunit.	Oxygen	51-57	egl-9 family hypoxia inducible factor 1	Homo sapiens	21-25
29901150-9	2018	Furthermore, NT-PGC-1alpha overexpression alleviated the PE-induced suppression of fatty acid metabolism-associated protein expression, increased extracellular oxygen consumption and decreased lipid droplet accumulation in NRCMs.	Oxygen	160-166	PPARG coactivator 1 alpha	Rattus norvegicus	16-26
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	BCL2 apoptosis regulator	Homo sapiens	107-112
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	tumor protein p53	Homo sapiens	137-140
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	caspase 3	Homo sapiens	150-158
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	heat shock protein family A (Hsp70) member 5	Homo sapiens	160-165
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	DNA damage inducible transcript 3	Homo sapiens	167-171
30369300-9	2018	This was paralleled by a rise in peak oxygen uptake (VO2peak = 29.14 +- 5.34 versus 32.48 +- 5.75 ml kg-1 min-1, p = .04).	Oxygen	38-44	CD59 molecule (CD59 blood group)	Homo sapiens	106-111
29458646-7	2018	The electronegativity differences between the metal and oxygen was ZnO (1.79) &gt; CdO (1.75) &gt; CuO (1.54) &gt; AgO (1.51).	Oxygen	56-62	cell adhesion associated, oncogene regulated	Homo sapiens	83-86
29728002-5	2018	Particularly, the NC-MoS2 possesses an excellent adsorption capacity (439.09mgg-1) for Pb(II), which attributes to the integrated physicochemical adsorption resulting from the oxygen-containing functional groups on the surface of nanohybrid composites.	Oxygen	176-182	submaxillary gland androgen regulated protein 3B	Homo sapiens	87-93
29777774-0	2018	MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS/H2S pathway.	Oxygen	27-33	cystathionine beta synthase	Rattus norvegicus	84-87
29777774-5	2018	The objective of this study was to investigate the effect of miR-125b-5p on protecting against oxygen and glucose deprivation (OGD) injury in PC-12 cells by regulating CBS and H2S generation.	Oxygen	95-101	cystathionine beta synthase	Rattus norvegicus	168-171
30038238-6	2018	Chemical and probe-based analysis revealed a substantial decrease in cardiolipin content and an increase in reactive oxygen species generation in DDHD2 knockout cells.	Oxygen	117-123	DDHD domain containing 2	Mus musculus	146-151
30220284-0	2018	[Protective effects of high-density lipoprotein on mice cardiomyocytes induced by oxygen and glucose deprivation through Akt signaling pathway].	Oxygen	82-88	thymoma viral proto-oncogene 1	Mus musculus	121-124
30060489-0	2018	Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model.	Oxygen	17-23	galectin 3	Rattus norvegicus	94-104
30060489-0	2018	Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model.	Oxygen	17-23	toll-like receptor 4	Rattus norvegicus	115-135
29748146-3	2018	The inhibition of HIF-1alpha accumulation induced by compound 4b was attenuated by treating the cells with MG132, a proteasome inhibitor, in a concentration-dependent manner, indicating that the compound 4b induces oxygen-independent proteasomal degradation of HIF-1alpha.	Oxygen	215-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
29660163-7	2018	Nevertheless, upon modelling the reduction of the tyrosine residue in photosystem II (TyrZ ) and the protonation of Asp61, spontaneous proton transfer occurs, leading to the deprotonation of an oxygen atom bound to Mn1; thus making it available for O-O bond formation.	Oxygen	194-200	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	215-218
29660163-7	2018	Nevertheless, upon modelling the reduction of the tyrosine residue in photosystem II (TyrZ ) and the protonation of Asp61, spontaneous proton transfer occurs, leading to the deprotonation of an oxygen atom bound to Mn1; thus making it available for O-O bond formation.	Oxygen	249-252	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	215-218
29748146-3	2018	The inhibition of HIF-1alpha accumulation induced by compound 4b was attenuated by treating the cells with MG132, a proteasome inhibitor, in a concentration-dependent manner, indicating that the compound 4b induces oxygen-independent proteasomal degradation of HIF-1alpha.	Oxygen	215-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	261-271
29626600-1	2018	Catalase is a protective enzyme against oxidative stress and converts hydrogen peroxide into water and molecular oxygen.	Oxygen	113-119	catalase	Homo sapiens	0-8
30083516-5	2018	Results: Intrinsic susceptibility, oxygen-enhanced and dynamic contrast-enhanced MRI revealed significantly slower baseline R2* , lower hyperoxia-induced DeltaR2* and volume transfer constant Ktrans in the CALR tumors which were associated with significantly lower Hoechst 33342 uptake and greater pimonidazole-adduct formation.	Oxygen	35-41	calreticulin	Homo sapiens	206-210
30060357-9	2018	Oxygen consumption rate of siTimeless-1 and siTimeless-2 group were 3.686+-0.389 and 3.955+-0.431, respectively, significantly higher than 1.690+-0.297 of control group (P&lt;0.05); Oxygen consumption rate of Timeless overexpressed group was 1.302+-0.336, significantly lower than 3.185+-0.262 of vector transfected group (P&lt;0.05) Timeless inhibited the expression of p53.	Oxygen	0-6	timeless circadian regulator	Homo sapiens	29-37
30060357-9	2018	Oxygen consumption rate of siTimeless-1 and siTimeless-2 group were 3.686+-0.389 and 3.955+-0.431, respectively, significantly higher than 1.690+-0.297 of control group (P&lt;0.05); Oxygen consumption rate of Timeless overexpressed group was 1.302+-0.336, significantly lower than 3.185+-0.262 of vector transfected group (P&lt;0.05) Timeless inhibited the expression of p53.	Oxygen	0-6	timeless circadian regulator	Homo sapiens	46-54
30060357-9	2018	Oxygen consumption rate of siTimeless-1 and siTimeless-2 group were 3.686+-0.389 and 3.955+-0.431, respectively, significantly higher than 1.690+-0.297 of control group (P&lt;0.05); Oxygen consumption rate of Timeless overexpressed group was 1.302+-0.336, significantly lower than 3.185+-0.262 of vector transfected group (P&lt;0.05) Timeless inhibited the expression of p53.	Oxygen	0-6	tumor protein p53	Homo sapiens	371-374
30060357-9	2018	Oxygen consumption rate of siTimeless-1 and siTimeless-2 group were 3.686+-0.389 and 3.955+-0.431, respectively, significantly higher than 1.690+-0.297 of control group (P&lt;0.05); Oxygen consumption rate of Timeless overexpressed group was 1.302+-0.336, significantly lower than 3.185+-0.262 of vector transfected group (P&lt;0.05) Timeless inhibited the expression of p53.	Oxygen	182-188	timeless circadian regulator	Homo sapiens	29-37
30060357-9	2018	Oxygen consumption rate of siTimeless-1 and siTimeless-2 group were 3.686+-0.389 and 3.955+-0.431, respectively, significantly higher than 1.690+-0.297 of control group (P&lt;0.05); Oxygen consumption rate of Timeless overexpressed group was 1.302+-0.336, significantly lower than 3.185+-0.262 of vector transfected group (P&lt;0.05) Timeless inhibited the expression of p53.	Oxygen	182-188	timeless circadian regulator	Homo sapiens	46-54
29402177-4	2018	These studies have elucidated LRRK2-related mechanisms of mitochondrial dysregulation, increased reactive oxygen species, truncated and simplified neurites, and cell death.	Oxygen	106-112	leucine rich repeat kinase 2	Homo sapiens	30-35
29679806-6	2018	Meanwhile, CAT within mpg-C3N4 could trigger decomposition of endogenic TME H2O2 to increase oxygen supply in-situ to relieve tumor hypoxia.	Oxygen	93-99	catalase	Homo sapiens	11-14
30005601-15	2018	PC-depleted cells demonstrated a decrease in glycolytic capacity and oxygen consumption rates and an enhanced sensitivity to oxidative stress.	Oxygen	69-75	pyruvate carboxylase	Homo sapiens	0-2
29980690-1	2018	Signaling by members of the transforming growth factor-beta (TGF-beta) superfamily, such as TGF-beta3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology.	Oxygen	116-122	tumor necrosis factor	Homo sapiens	28-59
29967369-0	2018	Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.	Oxygen	11-17	sclerostin	Homo sapiens	78-88
29967369-7	2018	Thus, oxygen sensing by PHD2 in osteocytes negatively regulates bone mass through epigenetic regulation of sclerostin and targeting PHD2 elicits an osteo-anabolic response in osteoporotic models.	Oxygen	6-12	egl-9 family hypoxia inducible factor 1	Homo sapiens	24-28
29967369-7	2018	Thus, oxygen sensing by PHD2 in osteocytes negatively regulates bone mass through epigenetic regulation of sclerostin and targeting PHD2 elicits an osteo-anabolic response in osteoporotic models.	Oxygen	6-12	sclerostin	Homo sapiens	107-117
29967369-7	2018	Thus, oxygen sensing by PHD2 in osteocytes negatively regulates bone mass through epigenetic regulation of sclerostin and targeting PHD2 elicits an osteo-anabolic response in osteoporotic models.	Oxygen	6-12	egl-9 family hypoxia inducible factor 1	Homo sapiens	132-136
28782878-8	2018	CFS workload decreased on day 2, alongside a decrease in HR but with an increase in V O2 (ml  kg  min-1 ).	Oxygen	86-88	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
29746306-1	2018	PURPOSE OF REVIEW: Historically, the identity of O2-sensing renal erythropoietin (Epo)-producing (REP) cells was a matter of debate.	Oxygen	49-51	erythropoietin	Homo sapiens	66-80
29746306-1	2018	PURPOSE OF REVIEW: Historically, the identity of O2-sensing renal erythropoietin (Epo)-producing (REP) cells was a matter of debate.	Oxygen	49-51	erythropoietin	Homo sapiens	82-85
29812941-6	2018	Using PARP-1 as a model protein, we report that treatment of ADP-ribosylated peptides with hydrofluoric acid generates a specific +132 Da mass signature that corresponds to the decomposition of mono- and poly(ADP-ribosylated) peptides into ribose adducts as a consequence of the cleavage of the phosphorus-oxygen bonds.	Oxygen	306-312	poly(ADP-ribose) polymerase 1	Homo sapiens	6-12
31458879-0	2018	Catalytic Application of Oxygen Vacancies Induced by Bi3+ Incorporation in ThO2 Samples Obtained by Solution Combustion Synthesis.	Oxygen	25-31	THO complex 2	Homo sapiens	75-79
29788427-8	2018	Perhaps reflecting the dependence of PAM on molecular oxygen, many PAM-responsive genes are known to be hypoxia responsive.	Oxygen	54-60	uncharacterized protein	Chlamydomonas reinhardtii	37-40
29788427-8	2018	Perhaps reflecting the dependence of PAM on molecular oxygen, many PAM-responsive genes are known to be hypoxia responsive.	Oxygen	54-60	uncharacterized protein	Chlamydomonas reinhardtii	67-70
29538230-10	2018	Cytochrome c increased oxygen consumption on Day 15 and platelet mitochondrial membrane potential steadily decreased over time, an effect attenuated by Res or Cyt c supplementation 10 days post-storage.	Oxygen	23-29	cytochrome c, somatic	Homo sapiens	0-12
29774488-0	2018	The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.	Oxygen	14-20	sirtuin 3	Homo sapiens	24-29
29774488-11	2018	In the absence of oxygen these Sirt3-dependent effects were abolished.	Oxygen	18-24	sirtuin 3	Homo sapiens	31-36
29774488-12	2018	These data indicate, that Sirt3-mediated myocardial protection is oxygen-dependent.	Oxygen	66-72	sirtuin 3	Homo sapiens	26-31
29119535-9	2018	Mitochondrial O2 consumption related to mt-HK activation by 2-deoxyglucose was also higher in CSy.	Oxygen	14-16	hexokinase 1	Homo sapiens	43-45
29941933-7	2018	Interestingly, aspartate levels also decrease under low oxygen, and increasing aspartate import by SLC1A3 provides a competitive advantage to cancer cells at low oxygen levels and in tumour xenografts.	Oxygen	162-168	solute carrier family 1 member 3	Homo sapiens	99-105
29655763-0	2018	Sleeping oxygen saturation, rapid eye movement sleep, and the adaptation of postprandial metabolic function in insulin sensitive and resistant individuals without diabetes.	Oxygen	9-15	insulin	Homo sapiens	111-118
29502264-7	2018	CO was higher when inhaling O2-poor gas mixtures with or without CO2 (~ 17 L min-1) than in the other conditions (~ 14 L min-1, p &lt; 0.001).	Oxygen	28-30	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
29672776-0	2018	Postoperative Monitoring of Free DIEP Flap in Breast Reconstruction with Near-Infrared Spectroscopy: Variables Affecting the Regional Oxygen Saturation.	Oxygen	134-140	arachidonate 5-lipoxygenase activating protein	Homo sapiens	38-42
29672776-4	2018	The aim of this study is to identify patient and flap-related variables that can affect regional oxygen saturation (rSO2).	Oxygen	97-103	arachidonate 5-lipoxygenase activating protein	Homo sapiens	49-53
29655763-10	2018	CONCLUSION: Sleeping oxygen desaturation and diminished REM duration are associated with a metabolic pattern that reflects a compensatory adaptation of postprandial insulin metabolism accompanying preclinical diabetic risk.	Oxygen	21-27	insulin	Homo sapiens	165-172
29516744-5	2018	The obtained results have shown that EPO does not only regulate [Hb] by erythropoiesis stimulation but also by PV modulation, which probably aims at keeping proper level of arterial oxygen content for oxygen delivery to tissues.	Oxygen	182-188	erythropoietin	Homo sapiens	37-40
29516744-5	2018	The obtained results have shown that EPO does not only regulate [Hb] by erythropoiesis stimulation but also by PV modulation, which probably aims at keeping proper level of arterial oxygen content for oxygen delivery to tissues.	Oxygen	201-207	erythropoietin	Homo sapiens	37-40
29882235-5	2018	It is demonstrated that this biomimetic core-shell nanoplatform with oxygen generation can be partial to accumulate in tumor and downregulate the expression of hypoxia-inducible factor 1alpha, which can further enhance the therapeutic effects of chemotherapy and reduce the expression of programmed death ligand 1 (PD-L1).	Oxygen	69-75	CD274 antigen	Mus musculus	288-313
29852735-4	2018	In this mechanism, the O2 molecule first dissociates from the Mn sites in order, that is, the O atom coordinating to the Mn3 (O5a) first dissociates, then the other O atom coordinating to the Mn1 (O5d) dissociates in the next step in the late S4 state (1   2).	Oxygen	23-25	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	192-195
29891713-5	2018	Here we show that Cx43 plays a critical role in astrocyte apoptosis and the resulting preretinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	136-142	gap junction protein, alpha 1	Mus musculus	18-22
29432891-1	2018	Erythrocyte storage induces a nonphysiological increase in hemoglobin-oxygen affinity (quantified by low p50, the oxygen tension at 50% hemoglobin saturation), which can be restored through biochemical rejuvenation.	Oxygen	70-76	nuclear factor kappa B subunit 1	Homo sapiens	105-108
29432891-1	2018	Erythrocyte storage induces a nonphysiological increase in hemoglobin-oxygen affinity (quantified by low p50, the oxygen tension at 50% hemoglobin saturation), which can be restored through biochemical rejuvenation.	Oxygen	114-120	nuclear factor kappa B subunit 1	Homo sapiens	105-108
29717634-5	2018	We have shown that when activated under conditions of 5% O2, Notch signaling dramatically increases the rate of glycolysis, improves proliferation efficiency, prevents senescence, and maintains the multipotency of hASCs.	Oxygen	57-59	notch receptor 1	Homo sapiens	61-66
29882235-5	2018	It is demonstrated that this biomimetic core-shell nanoplatform with oxygen generation can be partial to accumulate in tumor and downregulate the expression of hypoxia-inducible factor 1alpha, which can further enhance the therapeutic effects of chemotherapy and reduce the expression of programmed death ligand 1 (PD-L1).	Oxygen	69-75	CD274 antigen	Mus musculus	315-320
29988564-7	2018	Inhibition of either channel decreased basal O2 consumption rate but only RyR1 inhibition decreased ATP-linked O2 consumption.	Oxygen	111-113	ryanodine receptor 1	Homo sapiens	74-78
29925335-6	2018	HIF1-alpha is stabilised in response to low oxygen levels in the cellular environment and its expression is seen in hypoxic regions throughout the tumour.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
29921218-15	2018	Further researches must be conducted to elucidate the molecular mechanism underlying LKB1/AMPK response to oxygen supply.	Oxygen	107-113	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	90-94
29895831-0	2018	Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-89
29627613-4	2018	Infrared spectroscopic confirm that the Pir behaves as a bidentate ligand co-ordinated to the metal ions via the oxygen and nitrogen atoms of nu(CO)carbonyl and nu(CN)pyridyl, respectively.	Oxygen	113-119	pirin	Homo sapiens	40-43
29895317-7	2018	Interestingly, a 1% O2 concentration ensured better percentages of CD34+Lin- cells and LTC-IC cells.	Oxygen	20-22	CD34 molecule	Homo sapiens	67-71
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	vascular endothelial growth factor A	Homo sapiens	52-86
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	vascular endothelial growth factor A	Homo sapiens	88-92
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	interleukin 6	Homo sapiens	118-136
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	interleukin 7	Homo sapiens	138-142
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	thrombopoietin	Homo sapiens	172-186
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	thrombopoietin	Homo sapiens	188-191
29917232-7	2018	Taken together, these findings demonstrate a key role for the PHD2-HIF-2alpha couple in Type I cells with respect to the oxygen sensing functions of the carotid body.	Oxygen	121-127	egl-9 family hypoxia inducible factor 1	Homo sapiens	62-66
29917232-16	2018	These findings implicate specific components of the HIF hydroxylase pathway (PHD2 and HIF-2alpha) within Type I cells of the carotid body with respect to the oxygen sensing and adaptive functions of that organ.	Oxygen	158-164	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
29799201-2	2018	XPS analysis shows the CuCo2O4@CQDs possesses the Co(II)-rich surface associated with the oxygen vacancies, which can effectively boost the Faradaic reactions and oxygen evolution reaction (OER) activity.	Oxygen	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29799201-2	2018	XPS analysis shows the CuCo2O4@CQDs possesses the Co(II)-rich surface associated with the oxygen vacancies, which can effectively boost the Faradaic reactions and oxygen evolution reaction (OER) activity.	Oxygen	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29799201-5	2018	The synergy of Co(II)-rich surface, oxygen vacancies, and well-defined 3D hollow structures facilitates the subsequent surface electrochemical reactions.	Oxygen	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
30857083-10	2018	Key controls on oxygen transfer efficiency within the aerated treatment system were also determined, revealing that standard oxygen transfer efficiency was inversely related to aeration rate between 1 L and 3 L min-1 and positively related to bed media depth between 1500 mm and 3000 mm.	Oxygen	125-131	CD59 molecule (CD59 blood group)	Homo sapiens	211-216
29845135-0	2018	Spin crossover dynamics studies on the thermally activated molecular oxygen binding mechanism on a model copper complex.	Oxygen	69-75	spinster	Drosophila melanogaster	0-4
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	43-51	spinster	Drosophila melanogaster	183-187
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	43-51	spinster	Drosophila melanogaster	252-256
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	53-55	spinster	Drosophila melanogaster	183-187
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	53-55	spinster	Drosophila melanogaster	252-256
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	215-223	spinster	Drosophila melanogaster	183-187
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Oxygen	215-223	spinster	Drosophila melanogaster	252-256
29845135-2	2018	In this work, we presented the early-stage ultrafast spin flip dynamics of O2 binding for a simplified monocopper complex, involving the coupled singlet and triplet electronic states.	Oxygen	75-77	spinster	Drosophila melanogaster	53-57
29895831-3	2018	Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death.	Oxygen	198-204	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-34
29895831-3	2018	Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death.	Oxygen	198-204	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
29895831-3	2018	Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death.	Oxygen	198-204	hypoxia inducible factor 1 subunit alpha	Homo sapiens	269-274
29895831-5	2018	It was demonstrated that HIF-1 is involved in suppressing oxygen consumption and facilitating glycolysis in cells and that the resistance to propofol-induced cell death was established in a HIF-1 activation-dependent manner.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-30
29446169-5	2018	RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 .	Oxygen	36-38	interleukin 6	Homo sapiens	112-116
29879119-8	2018	Finally, we find that the oxygen-sensing guanylate cyclase GCY-35, which normally localizes at the dendrite ending, is localized throughout the overgrown region, and that overgrowth can be suppressed by overexpressing GCY-35 or by genetically mimicking elevated cGMP signaling.	Oxygen	26-32	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	59-65
29879119-8	2018	Finally, we find that the oxygen-sensing guanylate cyclase GCY-35, which normally localizes at the dendrite ending, is localized throughout the overgrown region, and that overgrowth can be suppressed by overexpressing GCY-35 or by genetically mimicking elevated cGMP signaling.	Oxygen	26-32	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	218-224
29882755-3	2018	In this review we will focus on the role of HIF1&amp;alpha; and HIF2&amp;alpha; isoforms in lung responses to oxygen insufficiency.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-48
29882755-6	2018	In summary, we will review the biological functions executed by HIF1 or HIF2 in the pulmonary vessels and epithelium to control lung responses to oxygen fluctuations as well as their pathological consequences in the hypoxic lung.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-68
29446169-5	2018	RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 .	Oxygen	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-229
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	ATP binding cassette subfamily B member 1	Homo sapiens	244-266
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	ATP binding cassette subfamily B member 1	Homo sapiens	268-272
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	ATP binding cassette subfamily B member 1	Homo sapiens	278-292
30026868-5	2018	Results: The precise oxygen preservation and release of the HPOC guaranteed sufficient tumor oxygenation, which is able to break hypoxia-induced chemoresistance by downregulating the expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), multidrug resistance 1 (MDR1) and P-glycoprotein (P-gp), resulting in minimized cellular efflux of chemodrug.	Oxygen	21-27	ATP binding cassette subfamily B member 1	Homo sapiens	294-298
29928235-6	2018	However, increases in minute ventilation during severe hypoxia (8% O2) were, if affected at all, augmented by AMPK-alpha1 and AMPK-alpha2 deletion in smooth muscles; despite the fact that hypoxia (8% O2) evoked falls in arterial SpO2 comparable with controls.	Oxygen	67-69	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	110-121
29928235-6	2018	However, increases in minute ventilation during severe hypoxia (8% O2) were, if affected at all, augmented by AMPK-alpha1 and AMPK-alpha2 deletion in smooth muscles; despite the fact that hypoxia (8% O2) evoked falls in arterial SpO2 comparable with controls.	Oxygen	67-69	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	126-137
29688635-6	2018	On the one hand, catalase can catalyze intracellular H2 O2 into O2 and promote PDT efficiency.	Oxygen	56-58	catalase	Homo sapiens	17-25
29446169-5	2018	RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 .	Oxygen	36-38	interleukin 6	Homo sapiens	97-110
29334615-1	2018	Recent examinations have shown lower maximal oxygen consumption during traditional ramp (RAMP) compared with self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac output.	Oxygen	45-51	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	83-87
29334615-1	2018	Recent examinations have shown lower maximal oxygen consumption during traditional ramp (RAMP) compared with self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac output.	Oxygen	45-51	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	89-93
29540304-1	2018	Cytochrome c (Cyt c) was rapidly oxidized by molecular oxygen in the presence, but not absence of PEG.	Oxygen	55-61	cytochrome c, somatic	Homo sapiens	0-12
30002689-0	2018	MicroRNA-135b-5p prevents oxygen-glucose deprivation and reoxygenation-induced neuronal injury through regulation of the GSK-3beta/Nrf2/ARE signaling pathway.	Oxygen	26-32	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
29540304-1	2018	Cytochrome c (Cyt c) was rapidly oxidized by molecular oxygen in the presence, but not absence of PEG.	Oxygen	55-61	cytochrome c, somatic	Homo sapiens	14-19
29753074-3	2018	Fluorescent measurements as well as oxygen production experiments showed that catalase was responsible for most of the decomposition of H2O2 at cell densities suitable for both experimental settings (0.1-10 x 1010 cell L-1), since sodium azide but not N-ethylmaleimide (NEM) inhibited H2O2 consumption.	Oxygen	36-42	catalase	Homo sapiens	78-86
29678610-4	2018	In mouse lung epithelial cells subjected to oxygen and glucose deprivation/reperfusion (OGD/Rep), Nrf2 silencing increased the OGD/Rep-induced upregulation of TLR4 and MyD88 and downregulation of HO-1, and exacerbated OGD/Rep-induced apoptosis, autophagy, and the downregulation of phospho-Akt.	Oxygen	44-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
29898517-8	2018	According to the effect on the decrease in soil pH, the attendant anions form the following series: SO42-   Cl- &gt; NO3- &gt; Ac- &gt; PO42- &gt; O2-, which correlates with the Cu LBC content.	Oxygen	147-149	NBL1, DAN family BMP antagonist	Homo sapiens	117-120
29772534-1	2018	The three mammalian isoforms of nitric oxide synthase (NOS) produce the signalling molecule nitric oxide (NO) from L-arginine, molecular oxygen, and NADPH.	Oxygen	137-143	nitric oxide synthase 2	Homo sapiens	32-53
29318655-4	2018	This enabled LK7-HH to arrest the generation of reactive oxygen species catalyzed by Cu2+ or Cu2+ -Abeta complex, and to inhibit Cu2+ -induced Abeta aggregation.	Oxygen	57-63	amyloid beta precursor protein	Homo sapiens	99-104
29659033-13	2018	Using a cell model of human umbilical cord vein endothelial cells cultured under physiological chronic low O2 (3% O2 ), we showed that GNA11 small interfering RNA (siRNA) dramatically inhibited (P &lt; 0.05) FGF2- and VEGFA-stimulated fetoplacental endothelial migration (by ~36% and ~50%, respectively) but not proliferation and permeability.	Oxygen	107-109	G protein subunit alpha 11	Homo sapiens	135-140
29659033-13	2018	Using a cell model of human umbilical cord vein endothelial cells cultured under physiological chronic low O2 (3% O2 ), we showed that GNA11 small interfering RNA (siRNA) dramatically inhibited (P &lt; 0.05) FGF2- and VEGFA-stimulated fetoplacental endothelial migration (by ~36% and ~50%, respectively) but not proliferation and permeability.	Oxygen	114-116	G protein subunit alpha 11	Homo sapiens	135-140
29573705-10	2018	Our hypothesis is that during collagen IV network formation PXDN cooperates with a NOX/DUOX-independent H2O2 source that is functional also at very low ambient oxygen levels.	Oxygen	160-166	peroxidasin	Homo sapiens	60-64
29339137-4	2018	In mouse embryonic stem cells, oxygen concentrations modulated the transcriptional regulation of the TET family of enzymes, as well as the de novo methyltransferase Dnmt3a.	Oxygen	31-37	DNA methyltransferase 3A	Mus musculus	165-171
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	SET domain, bifurcated 1	Mus musculus	198-204
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	lysine (K)-specific demethylase 1A	Mus musculus	240-245
29130390-4	2018	METHODS: A blood cell analyzer and a blood oxygen analyzer were used to conduct routine blood tests and measure the oxygen affinity P50 in in the Han population that rapidly entered the plateau (for 3-7 days), the plateau-acclimatized Han population (residing for 30 days on the plateau), the plateau Han population (more than 10 years on the plateau), and the Tibetan population.	Oxygen	116-122	nuclear factor kappa B subunit 1	Homo sapiens	132-135
29877830-9	2018	This CMOS-enabled oxygen sensor was then employed to test water quality from different sources (tap water, lakes, and rivers).	Oxygen	18-24	SEC14 like lipid binding 2	Homo sapiens	96-99
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	heme oxygenase 1	Mus musculus	54-70
29530984-3	2018	Herein, we report that cytochrome c, in the presence of either cardiolipin (CL), O2 and H2O2, or oxidized CL and O2, catalyzes the oxidation of the plasmalogen vinyl ether linkage, promoting its hydrolytic cleavage and resultant production of 2-AA-lysolipids and highly reactive alpha-hydroxy fatty aldehydes.	Oxygen	81-83	cytochrome c, somatic	Homo sapiens	23-35
29530984-3	2018	Herein, we report that cytochrome c, in the presence of either cardiolipin (CL), O2 and H2O2, or oxidized CL and O2, catalyzes the oxidation of the plasmalogen vinyl ether linkage, promoting its hydrolytic cleavage and resultant production of 2-AA-lysolipids and highly reactive alpha-hydroxy fatty aldehydes.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	23-35
29575791-7	2018	CARD9 absence significantly modified O2 consumption, CO2 production and heat production.	Oxygen	37-39	caspase recruitment domain family, member 9	Mus musculus	0-5
29155057-7	2018	Short exposures to 5% and 10% O2, efficiently activated anti-apoptotic mechanisms through NFkappaB activation, HIF1alpha and gammaH2AX related DNA damage repair pathways.	Oxygen	30-32	nuclear factor kappa B subunit 1	Homo sapiens	90-98
29155057-7	2018	Short exposures to 5% and 10% O2, efficiently activated anti-apoptotic mechanisms through NFkappaB activation, HIF1alpha and gammaH2AX related DNA damage repair pathways.	Oxygen	30-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-120
29459227-4	2018	SiRNA silencing of JAK1, STAT3 and NOX4 diminished the hypoxia-mediated effect while a role of HIF1alpha could be clearly ruled out by the response to hypoxia-mimetics and competition experiments with a plasmid harboring the oxygen-dependent degradation domain of HIF1alpha.	Oxygen	225-231	Janus kinase 1	Homo sapiens	19-23
29459227-9	2018	It remains to be studied whether the peroxide-STAT3-hepcidin axis simply acts to continuously compensate for oxygen fluctuations or is directly involved in iron sensing per se.	Oxygen	109-115	signal transducer and activator of transcription 3	Homo sapiens	46-51
29498054-9	2018	Subsequently, EPO accumulated in plasma indicating decreased O2 availability in the kidneys.	Oxygen	61-63	erythropoietin	Homo sapiens	14-17
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	Oxygen	107-113	CD33 molecule	Homo sapiens	58-62
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	Oxygen	107-113	NLR family pyrin domain containing 3	Homo sapiens	126-131
29843785-7	2018	In vivo markers of angiogenesis (vascular endothelial growth factor, angiopoietin 2 [Ang2], tyrosine kinase receptor [Tie2]) were significantly associated with oxidative damage and oxygen metabolism in the inflamed synovium.	Oxygen	181-187	vascular endothelial growth factor A	Homo sapiens	33-67
29851229-9	2018	Their mean VO2 max in GXT and O2 uptake at the end of the 6MWT were 34 4 ml kg-1 min-1 (SD +- 7 6) and 27 2  ml kg-1 min-1 (SD +- 6 5), respectively.	Oxygen	12-14	CD59 molecule (CD59 blood group)	Homo sapiens	81-97
29851229-9	2018	Their mean VO2 max in GXT and O2 uptake at the end of the 6MWT were 34 4 ml kg-1 min-1 (SD +- 7 6) and 27 2  ml kg-1 min-1 (SD +- 6 5), respectively.	Oxygen	12-14	CD59 molecule (CD59 blood group)	Homo sapiens	117-133
29955245-7	2018	The current review focuses on the induction of liver inflammation, fibrosis, and steatosis by free cholesterol via the hypoxia-inducible factor 1alpha (HIF-1alpha), a main oxygen-sensing transcription factor involved in all stages of NAFLD.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-150
29955245-7	2018	The current review focuses on the induction of liver inflammation, fibrosis, and steatosis by free cholesterol via the hypoxia-inducible factor 1alpha (HIF-1alpha), a main oxygen-sensing transcription factor involved in all stages of NAFLD.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
29799025-3	2018	Our current study focused on the interaction of HBx with a transcription factor, hypoxia-inducible factor-1alpha (HIF-1alpha), which is stabilized by low O2 condition (hypoxia) and is found to be frequently overexpressed in HCC intra-tumorally due to poor blood perfusion.	Oxygen	154-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-112
32254386-5	2018	The lysosome-targeted derivative exhibits higher cellular uptake and more efficient reactive oxygen species generation inside HeLa cells, resulting in higher PDT efficacy with an IC50 value of 0.48 muM and cell death mainly through apoptosis.	Oxygen	93-99	latexin	Homo sapiens	198-201
29799025-3	2018	Our current study focused on the interaction of HBx with a transcription factor, hypoxia-inducible factor-1alpha (HIF-1alpha), which is stabilized by low O2 condition (hypoxia) and is found to be frequently overexpressed in HCC intra-tumorally due to poor blood perfusion.	Oxygen	154-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
29621550-0	2018	RETRACTED: Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway.	Oxygen	55-61	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	102-108
29669911-7	2018	Furthermore, the MPC inhibitor, UK5099, blocked PGC-1alpha-induced pyruvate-dependent mitochondrial oxygen consumption.	Oxygen	100-106	PPARG coactivator 1 alpha	Homo sapiens	48-58
29741888-0	2018	Electron and Oxygen Atom Transfer Chemistry of Co(II) in a Proton Responsive, Redox Active Ligand Environment.	Oxygen	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
29955245-8	2018	Cholesterol loading in hepatocytes can result in chronic HIF-1alpha activity because of the decreased oxygen availability and excessive production of nitric oxide and mitochondrial reactive oxygen species.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
29485192-4	2018	Minute modifications of oxygen availability, either positive or negative, induce the expression of specific genes, the major actors of this responses being the transcription factors HIF and Nrf2 that control the attempt to cope with low oxygen (hypoxia) or to either high oxygen or to an oxygen "overflow," respectively.	Oxygen	24-30	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	peroxisome proliferator activated receptor gamma	Homo sapiens	68-73
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	PPARG coactivator 1 alpha	Homo sapiens	123-131
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	PPARG coactivator 1 beta	Homo sapiens	133-141
28971989-0	2018	Inhibition of mammalian target of rapamycin decreases intrarenal oxygen availability and alters glomerular permeability.	Oxygen	65-71	mechanistic target of rapamycin kinase	Homo sapiens	14-43
28971989-8	2018	In both groups, mTOR inhibition induced mitochondrial uncoupling, resulting in increased total kidney oxygen consumption and decreased intrarenal oxygen availability.	Oxygen	102-108	mechanistic target of rapamycin kinase	Homo sapiens	16-20
28971989-8	2018	In both groups, mTOR inhibition induced mitochondrial uncoupling, resulting in increased total kidney oxygen consumption and decreased intrarenal oxygen availability.	Oxygen	146-152	mechanistic target of rapamycin kinase	Homo sapiens	16-20
28971989-11	2018	In conclusion, mTOR inhibition induces mitochondrial dysfunction leading to decreased oxygen availability in normal and diabetic kidneys, which translates into increased KIM-1 in the urine.	Oxygen	86-92	mechanistic target of rapamycin kinase	Homo sapiens	15-19
29715084-5	2018	O2 - derived from pirarubicin in the presence of Cu(II) was detected by cytochrome c reduction.	Oxygen	0-2	cytochrome c, somatic	Homo sapiens	72-84
29466710-1	2018	Uncoupled endothelial nitric oxide synthase (eNOS) produces O2- instead of nitric oxide (NO).	Oxygen	60-62	nitric oxide synthase 3	Homo sapiens	10-43
29466710-1	2018	Uncoupled endothelial nitric oxide synthase (eNOS) produces O2- instead of nitric oxide (NO).	Oxygen	60-62	nitric oxide synthase 3	Homo sapiens	45-49
29537672-9	2018	Interestingly, the NADH-stimulated oxygen consumption and ATP synthesis increased in the presence of the physiological platelets agonists, thrombin or collagen.	Oxygen	35-41	coagulation factor II, thrombin	Homo sapiens	139-147
29486169-9	2018	The highest V O2 achieved at 115%, 130%, and 170% of iV O2max was 54.2 +- 7.9 mL kg-1 min-1, 52.5 +- 8.1 mL kg-1 min-1, and 49.6 +- 7.5 mL kg-1 min-1, respectively.	Oxygen	14-16	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
29486169-9	2018	The highest V O2 achieved at 115%, 130%, and 170% of iV O2max was 54.2 +- 7.9 mL kg-1 min-1, 52.5 +- 8.1 mL kg-1 min-1, and 49.6 +- 7.5 mL kg-1 min-1, respectively.	Oxygen	14-16	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
29486169-9	2018	The highest V O2 achieved at 115%, 130%, and 170% of iV O2max was 54.2 +- 7.9 mL kg-1 min-1, 52.5 +- 8.1 mL kg-1 min-1, and 49.6 +- 7.5 mL kg-1 min-1, respectively.	Oxygen	14-16	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
29530922-5	2018	Physiologically, the hypoxia response is tempered through HIF-1alpha hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2) and subsequent ubiquitination and degradation.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
29530922-5	2018	Physiologically, the hypoxia response is tempered through HIF-1alpha hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2) and subsequent ubiquitination and degradation.	Oxygen	90-96	egl-9 family hypoxia inducible factor 1	Homo sapiens	105-140
29530922-5	2018	Physiologically, the hypoxia response is tempered through HIF-1alpha hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2) and subsequent ubiquitination and degradation.	Oxygen	90-96	egl-9 family hypoxia inducible factor 1	Homo sapiens	142-146
29529249-1	2018	HIF1alpha (hypoxia inducible factor 1alpha) is the central regulator of the cellular response to low oxygen and its activity is deregulated in multiple human pathologies.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
29529249-1	2018	HIF1alpha (hypoxia inducible factor 1alpha) is the central regulator of the cellular response to low oxygen and its activity is deregulated in multiple human pathologies.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-42
29485192-4	2018	Minute modifications of oxygen availability, either positive or negative, induce the expression of specific genes, the major actors of this responses being the transcription factors HIF and Nrf2 that control the attempt to cope with low oxygen (hypoxia) or to either high oxygen or to an oxygen "overflow," respectively.	Oxygen	237-243	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
29485192-4	2018	Minute modifications of oxygen availability, either positive or negative, induce the expression of specific genes, the major actors of this responses being the transcription factors HIF and Nrf2 that control the attempt to cope with low oxygen (hypoxia) or to either high oxygen or to an oxygen "overflow," respectively.	Oxygen	237-243	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
29485192-4	2018	Minute modifications of oxygen availability, either positive or negative, induce the expression of specific genes, the major actors of this responses being the transcription factors HIF and Nrf2 that control the attempt to cope with low oxygen (hypoxia) or to either high oxygen or to an oxygen "overflow," respectively.	Oxygen	237-243	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
29032465-2	2018	Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-165
29611698-2	2018	Cu bound to Abeta is able to produce reactive oxygen species (ROS) by the successive reductions of molecular dioxygen, and the ROS produced contribute to oxidative stress.	Oxygen	109-117	amyloid beta precursor protein	Homo sapiens	12-17
29453066-10	2018	Oxidation resistance was enhanced by the formation of new MgP crystals, which prevented the oxidation of CC, CC, and CH into CO, CO, and COOH, respectively, by acting as a physical barrier between the biochar surface and oxygen.	Oxygen	221-227	matrix Gla protein	Bos taurus	58-61
29437791-3	2018	A phase I study of CPI-613 plus cytarabine and mitoxantrone was conducted in patients with relapsed or refractory AML.Results: Exposure to chemotherapy induced mitochondrial oxygen consumption that depended on PDH.	Oxygen	174-180	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	210-213
29546425-4	2018	Human cytotrophoblasts cultured in 20% O2 spontaneously differentiate to syncytiotrophoblast with induction of hCYP191A/aromatase, a marker of differentiation.	Oxygen	39-41	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	111-129
29488201-2	2018	First of all, a chemical oxygen demand (COD) and color removal efficiency of 66 and 63% was achieved at initial pH of 6.8, 25 mmol L-1 of H2O2, and 2 g L-1 of Fe0 in the Fe0/H2O2 reaction.	Oxygen	25-31	L1 cell adhesion molecule	Homo sapiens	131-134
29488201-2	2018	First of all, a chemical oxygen demand (COD) and color removal efficiency of 66 and 63% was achieved at initial pH of 6.8, 25 mmol L-1 of H2O2, and 2 g L-1 of Fe0 in the Fe0/H2O2 reaction.	Oxygen	25-31	L1 cell adhesion molecule	Homo sapiens	152-162
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	86-88	superoxide dismutase 1	Homo sapiens	54-57
29480936-0	2018	TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus.	Oxygen	106-112	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	0-4
29480936-0	2018	TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus.	Oxygen	106-112	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
29480936-3	2018	Here, we show that oxygen-glucose deprivation-reperfusion (OGD-RP), an in vitro model that mimic the pathological conditions of the ischemic stroke, increases the phosphorylation level of tropomyosin receptor kinase B (TrkB) in area CA3.	Oxygen	19-25	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	188-217
29480936-3	2018	Here, we show that oxygen-glucose deprivation-reperfusion (OGD-RP), an in vitro model that mimic the pathological conditions of the ischemic stroke, increases the phosphorylation level of tropomyosin receptor kinase B (TrkB) in area CA3.	Oxygen	19-25	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	219-223
29741264-6	2018	Secondary CE can also result from defects in the components of the oxygen-sensing pathway (PHD2, HIF2alpha and VHL).	Oxygen	67-73	egl-9 family hypoxia inducible factor 1	Homo sapiens	91-95
29795723-0	2018	Serum Tumor Necrosis Factor-alpha associates with Myocardial Oxygen Demand and Exercise Tolerance in Postmenopausal Women.	Oxygen	61-67	tumor necrosis factor	Homo sapiens	6-33
29795723-2	2018	The aims of this investigation were to examine the independent associations of TNF-alpha on myocardial oxygen demand at rest and during submaximal exercise, while also evaluating the association of TNF-alpha on exercise tolerance.	Oxygen	103-109	tumor necrosis factor	Homo sapiens	79-88
29795723-9	2018	These data suggest TNF-alpha independently associates with myocardial oxygen demand during physical exertion, thus highlighting the utility of higher-intensity efforts to expose important phenomena not apparent at rest.	Oxygen	70-76	tumor necrosis factor	Homo sapiens	19-28
29795728-1	2018	Dietary nitrate (NO3-) has been shown to reduce oxygen consumption (VO2) during moderate to high-intensity (e.g. time to fatigue, time trials) exercise and often in trained athletes.	Oxygen	48-54	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29795728-2	2018	However, less is known regarding prolonged exercise and the potential impact of NO3- on post-exercise excess oxygen consumption (EPOC), particularly in untrained individuals, who may have different metabolic goals during exercise than trained individuals.	Oxygen	109-115	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
28758835-6	2018	Rate of oxygen consumption decreased by 10% from IS to SS (IS: 37.9 +- 5.68 ml kg-1 min-1, SS: 34.1 +- 5.07 ml kg-1 min-1, P &lt; 0.0001, ES 3.05).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
29131393-0	2018	Flap monitoring with continuous oxygen partial tension measurement in breast reconstructive surgery: A preliminary report.	Oxygen	32-38	arachidonate 5-lipoxygenase activating protein	Homo sapiens	0-4
29763367-11	2018	Nitric oxide, nitric oxide synthase, and inducible nitric oxide synthase levels in the hippocampus were significantly increased after hyperbaric oxygen exposure, but reversed by geranylgeranylacetone, while heat shock protein 70 inhibitor quercetin could inhibit this effect of geranylgeranylacetone.	Oxygen	145-151	nitric oxide synthase 2	Rattus norvegicus	41-72
29763367-13	2018	In conclusion, overexpression of heat shock protein 70 in hippocampal neurons may protect rats from central nervous system oxygen toxicity by suppression of neuronal nitric oxide synthase and inducible nitric oxide synthase-mediated nitric oxide production and translocation of nuclear factor-kappaB to nucleus.	Oxygen	123-129	nitric oxide synthase 2	Rattus norvegicus	192-223
29731878-12	2018	Differences in oxygen concentration at primary sites and homing sites are important in the EMT-MET process, and the underlying mechanism may involve HIF-1alpha-Snail signaling.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
29731878-12	2018	Differences in oxygen concentration at primary sites and homing sites are important in the EMT-MET process, and the underlying mechanism may involve HIF-1alpha-Snail signaling.	Oxygen	15-21	snail family transcriptional repressor 1	Homo sapiens	160-165
29220697-4	2018	H2S was concentration- and oxygen-dependently oxidized by 1muM SOD to polysulfides (mainly H2S2, and to a lesser extent H2S3 and H2S5) with an EC50 of approximately 380muM H2S.	Oxygen	27-33	superoxide dismutase 1	Homo sapiens	63-66
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	86-88	superoxide dismutase 1	Homo sapiens	112-115
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	54-57
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	112-115
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	54-57
29220697-10	2018	These experiments suggest that, unlike the well-known SOD-mediated dismutation of two O2 - to form H2O2 and O2, SOD catalyzes a reaction using H2S and O2 to form persulfide.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	112-115
29797877-6	2018	The concentration of dissolved oxygen (DO) showed strong seasonal and spatial variations, with the range of 0.43-13.99 mg L-1.	Oxygen	31-37	immunoglobulin kappa variable 1-16	Homo sapiens	122-125
29611701-4	2018	The optimized Fe,Co,N-CNP(0.3) (Fe/Co molar ratio of 0.3 in Fe,Co-ZIF) electrocatalyst exhibited a highly promising activity for oxygen reduction reaction (ORR) with a positive half-wave potential ( E1/2) of 0.875 V (29 mV higher than that of the commercial Pt/C), excellent methanol tolerance, and electrochemical stability in the alkaline electrolyte.	Oxygen	129-135	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	22-25
29611701-2	2018	Herein, we present a novel and facile route for synthesis of iron-, cobalt-, and nitrogen-codoped carbon nanopolyhedra electrocatalysts (Fe,Co,N-CNP) by one-step pyrolysis of a new type of Fe/Co bimetal zeolitic imidazolate framework (Fe,Co-ZIF) crystals that were self-assembled by oxygen-free solvothermal reaction of Fe2+ and Co2+ with 2-methylimidazole.	Oxygen	283-289	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	145-148
29770194-2	2018	There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity.	Oxygen	74-80	vascular endothelial growth factor A	Homo sapiens	154-188
29666307-6	2018	IL-2-JAK1/3 signaling pathways thus increased the abundance of nutrient transporters, nutrient sensors, and critical oxygen-sensing molecules.	Oxygen	117-123	interleukin 2	Homo sapiens	0-4
29666307-6	2018	IL-2-JAK1/3 signaling pathways thus increased the abundance of nutrient transporters, nutrient sensors, and critical oxygen-sensing molecules.	Oxygen	117-123	Janus kinase 1	Homo sapiens	5-9
29666307-7	2018	These data provide key insights into how IL-2 promotes T cell function and highlight signaling mechanisms and transcription factors that integrate oxygen sensing to transcriptional control of CD8+ T cell differentiation.	Oxygen	147-153	interleukin 2	Homo sapiens	41-45
29582997-10	2018	The mechanism of the hydrolysis reaction of tBuNC is explained with support provided by DFT calculations; a positively polarized C atom of tBuNC on the Co(III) center is nucleophilically attacked by a hydroxide anion activated through an interaction of the sulfenyl/sulfinyl oxygen with the nucleophile.	Oxygen	275-281	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	152-159
29806308-13	2018	At 2 days, the MVD was significantly higher in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group ( P&lt;0.05); the expression of TNF-alpha was significantly lower in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group ( P&lt;0.05).	Oxygen	58-64	tumor necrosis factor	Rattus norvegicus	173-182
29268188-10	2018	Semi-quantitative detection of IL-8 consumption in HUVEC cells in low oxygen condition was also achieved.	Oxygen	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
29850636-2	2018	Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1beta, IL-10, and IL-8 and TNF-alpha in preterm newborns under mechanical ventilation (MV) in their first two days.	Oxygen	57-63	interleukin 6	Homo sapiens	127-131
29850636-2	2018	Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1beta, IL-10, and IL-8 and TNF-alpha in preterm newborns under mechanical ventilation (MV) in their first two days.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
29850636-11	2018	In the high oxygen group, IL-6, IL-8, and TNF-alpha plasma levels increased significantly after two hours under MV.	Oxygen	12-18	interleukin 6	Homo sapiens	26-30
29850636-11	2018	In the high oxygen group, IL-6, IL-8, and TNF-alpha plasma levels increased significantly after two hours under MV.	Oxygen	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
29850636-11	2018	In the high oxygen group, IL-6, IL-8, and TNF-alpha plasma levels increased significantly after two hours under MV.	Oxygen	12-18	tumor necrosis factor	Homo sapiens	42-51
29806308-13	2018	At 2 days, the MVD was significantly higher in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group ( P&lt;0.05); the expression of TNF-alpha was significantly lower in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group ( P&lt;0.05).	Oxygen	221-227	tumor necrosis factor	Rattus norvegicus	173-182
29806308-16	2018	The expression of TNF-alpha was significantly lower in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group, in combined group than in natural hirudin group and hyperbaric oxygen group ( P&lt;0.05).	Oxygen	66-72	tumor necrosis factor	Rattus norvegicus	18-27
29806308-16	2018	The expression of TNF-alpha was significantly lower in hyperbaric oxygen group, natural hirudin group, and combined group than that in control group, in combined group than in natural hirudin group and hyperbaric oxygen group ( P&lt;0.05).	Oxygen	213-219	tumor necrosis factor	Rattus norvegicus	18-27
29643458-7	2018	Human MSCs expressed HIF3alpha, differentially regulated by pro-inflammatory cytokines in an oxygen-independent manner, a novel and still uncharacterized mechanism, where NF-kappaB is critical for its expression.	Oxygen	93-99	hypoxia inducible factor 3 subunit alpha	Homo sapiens	21-30
29342315-6	2018	The result tallies with the fact that addition of O2 to MAO produces Me2 AlOMe from free Me3 Al which eventually leads to formation of oxidized MAO oligomers and changes in ion abundance.	Oxygen	50-52	malic enzyme 2	Homo sapiens	69-72
29628090-3	2018	In Test 1 of 95% AEB, removal rates of ammonia, total nitrogen (TN) and chemical oxygen demand (COD) reached 99.34%+-0.11%, 99.34%+-0.10% and 90.79%+-0.12%, respectively.	Oxygen	81-87	serine protease 21	Homo sapiens	3-9
29469815-2	2018	In the case of irradiation with 3 MeV Au ions where displacement cascade processes are dominant, the Ta L3-edge x-ray absorption measurements suggest that a peak corresponding to the Ta-O bonds in the TaO6 octahedra splits, which is attributed to the formation of TaK antisite defects that are coupled with oxygen vacancies, V O.	Oxygen	307-313	cyclin dependent kinase 9	Homo sapiens	264-267
29965002-7	2018	Under the same oxygen supply conditions, an initial NH4+-N concentration lower than 100 mg L-1 could inhibit the activity of AMX partly.	Oxygen	15-21	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
29965002-8	2018	However, with an initial NH4+-N concentration over 150 mg L-1, either oxygen-limiting or high free ammonia concentration could lead to the dramatic decrease of q(TN).	Oxygen	70-76	immunoglobulin kappa variable 1-16	Homo sapiens	58-61
29504411-5	2018	Apart from direct inhibitors, common pharmacological agents, herbal and dietary medicines as well as hyperbaric oxygen, low level laser and low intensity pulsed ultrasound have been shown to exhibit a chondroprotective effect by inhibiting the expression of iNOS.	Oxygen	112-118	nitric oxide synthase 2	Homo sapiens	258-262
29344798-10	2018	CONCLUSIONS: Oxygen desaturation during 6MWT was a good predictor for poor surgical outcomes in lung cancer patients with decreased ppo pulmonary function.	Oxygen	13-19	protoporphyrinogen oxidase	Homo sapiens	132-135
29452237-8	2018	Finally, we showed that chlordecone induces endothelial cells angiogenesis by a cross-talk involving NADPH oxidase and mitochondrial O2-via a NO sensitive pathways through activation of ERalpha.	Oxygen	133-135	estrogen receptor 1	Homo sapiens	186-193
28606854-7	2018	Under hypoxia (1% atmospheric O2), only glob1 overexpression enhanced the activity of mitochondrial oxidases and the ATP content.	Oxygen	30-32	globin 1	Drosophila melanogaster	40-45
29523748-0	2018	High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2.	Oxygen	77-83	AKT serine/threonine kinase 1	Homo sapiens	133-143
29438588-2	2018	Here, we report a molecular barium vanadium oxide, [Ba4 (dmso)14 V14 O38 (NO3 )] (={Ba4 V14 }) as viable homogeneous catalyst for a series of oxidation reactions in N,N-dimethyl formamide solution under oxygen (8 bar).	Oxygen	203-209	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
29606139-6	2018	It appears that Hif2alpha counteracts Hif1alpha and ROS-mediated protein deactivation under intermediate hypoxia and normoxia (20%), respectively, to regulate the response of cell cycle commitment to oxygen tension.	Oxygen	200-206	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-47
29674767-1	2018	The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen.	Oxygen	112-118	catalase	Homo sapiens	76-84
29351410-9	2018	The basal protein expression levels of STIM1/2, Orai1/2, and TRPC6 were higher in CASMC than in PASMC, but hypoxia (3% O2 for 72 h) significantly upregulated protein expression levels of STIM1/STIM2, Orai1/Orai2, and TRPC6 and increased the resting [Ca2+]cyt only in PASMC, but not in CASMC.	Oxygen	119-121	stromal interaction molecule 1	Homo sapiens	39-46
29351410-9	2018	The basal protein expression levels of STIM1/2, Orai1/2, and TRPC6 were higher in CASMC than in PASMC, but hypoxia (3% O2 for 72 h) significantly upregulated protein expression levels of STIM1/STIM2, Orai1/Orai2, and TRPC6 and increased the resting [Ca2+]cyt only in PASMC, but not in CASMC.	Oxygen	119-121	stromal interaction molecule 1	Homo sapiens	39-44
30417160-1	2018	The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in response to diverse stimuli such as variations in amino acid content, changes in cellular bioenergetics, oxygen levels, neurotrophic factors and xenobiotics.	Oxygen	268-274	mechanistic target of rapamycin kinase	Homo sapiens	4-57
29357480-3	2018	We aimed to investigate the effect of recombinant human EPO (rHuEPO) administration on healthy cerebral metabolism in humans during normoxia and during metabolic stress by inhalation of 10% O2 hypoxic air.	Oxygen	190-192	erythropoietin	Homo sapiens	56-59
28606854-13	2018	Together, the results indicate divergent functions of the Drosophila globins: glob1 may play a role in the O2-dependent metabolism while glob2 may protect spermatogenesis from reactive oxygen species.	Oxygen	107-109	globin 1	Drosophila melanogaster	78-83
29534204-16	2018	Interestingly, InhA expression was higher under 8% O2, while PlGF expression was inhibited compared to 21% O2.	Oxygen	51-53	inhibin subunit alpha	Homo sapiens	15-19
29429687-5	2018	The optimal overall yields of both NO2- and NO3- were obtained at the N2/O2 volume (in the sparged gas) ratio of 3:1 which is near to the ratio of N2/O2 in air.	Oxygen	73-75	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
29380818-7	2018	Furthermore, renin-expressing cells have an intricate lineage and functional relationship with erythropoietin-producing cells and are therefore central to two endocrine systems - the renin-angiotensin and erythropoietin systems - that sustain life by controlling fluid volume and composition, perfusion pressure and oxygen delivery to tissues.	Oxygen	316-322	renin	Homo sapiens	13-18
29380818-7	2018	Furthermore, renin-expressing cells have an intricate lineage and functional relationship with erythropoietin-producing cells and are therefore central to two endocrine systems - the renin-angiotensin and erythropoietin systems - that sustain life by controlling fluid volume and composition, perfusion pressure and oxygen delivery to tissues.	Oxygen	316-322	erythropoietin	Homo sapiens	183-219
29055589-2	2018	In this study, the seasonal and spatial variations of sediment oxygen demand (SOD) and the influencing factors were explored using pore water chemistry for the weir-impounded rivers.	Oxygen	63-69	superoxide dismutase 1	Homo sapiens	78-81
29371097-0	2018	Akt activation improves microregional oxygen supply/consumption balance after cerebral ischemia-reperfusion.	Oxygen	38-44	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
29567975-6	2018	In HEI-OC1 mouse inner ear cell lines, knockdown of Idh2 resulted in a decline in cell viability and mitochondrial oxygen consumption.	Oxygen	115-121	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	52-56
31458563-10	2018	The calculations show that a small part of the inorganic spins are delocalized over the oxygens from hfac {~0.03 for Co(II) and ~0.015 for Mn(II)}, whereas a more significant fraction {~0.24 for Mn(II) and ~0.13 for Co(II)} of delocalized spins from the metal ion is transferred to the coordinated oxygen atom(s) of nitronyl nitroxide.	Oxygen	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
31458563-10	2018	The calculations show that a small part of the inorganic spins are delocalized over the oxygens from hfac {~0.03 for Co(II) and ~0.015 for Mn(II)}, whereas a more significant fraction {~0.24 for Mn(II) and ~0.13 for Co(II)} of delocalized spins from the metal ion is transferred to the coordinated oxygen atom(s) of nitronyl nitroxide.	Oxygen	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
29518129-0	2018	STAT3 precedes HIF1alpha transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.	Oxygen	54-60	signal transducer and activator of transcription 3	Homo sapiens	0-5
29518129-0	2018	STAT3 precedes HIF1alpha transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-24
29518129-0	2018	STAT3 precedes HIF1alpha transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.	Oxygen	65-71	signal transducer and activator of transcription 3	Homo sapiens	0-5
29518129-0	2018	STAT3 precedes HIF1alpha transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-24
29518129-6	2018	However, we find that the transcription factors Jun Proto-Oncogene (c-JUN), Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells (NFkappaB) and signal transducer and activator of transcription 3 (STAT3) bind genes regulated after 2hours (hs) of omitted glucose and oxygen before HIF1alpha.	Oxygen	279-285	signal transducer and activator of transcription 3	Homo sapiens	158-208
29518129-6	2018	However, we find that the transcription factors Jun Proto-Oncogene (c-JUN), Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells (NFkappaB) and signal transducer and activator of transcription 3 (STAT3) bind genes regulated after 2hours (hs) of omitted glucose and oxygen before HIF1alpha.	Oxygen	279-285	signal transducer and activator of transcription 3	Homo sapiens	210-215
29518129-8	2018	Phosphorylated STAT3 protein is at its highest after 5 min of oxygen and glucose (OGD) deprivation, whereas maximum HIF1alpha stabilisation requires 120 min.	Oxygen	62-68	signal transducer and activator of transcription 3	Homo sapiens	15-20
29614715-7	2018	In the oxygen-induced retinopathy model in C57BL/6:Hsd mice, we demonstrate an endothelial cell count decrease.	Oxygen	7-13	histidine ammonia lyase	Mus musculus	51-54
29744282-2	2018	Three weak interactions were analyzed: 1) the CH/pi donor-acceptor interaction of phenyl rings in the PPh3 ligand, 2) the PhPPh3 face-on Cp stabilization, and 3) the hydrogen bond between the oxygen atom of the acyl group and an ortho-C-H bond of one of the PPh3 phenyl rings.	Oxygen	192-198	caveolin 1	Homo sapiens	124-128
29615839-10	2018	Through suppression of IGF-1R, miR-342-3p dampens glycolysis by decreasing glucose uptake, lactate generation, ATP production, and extracellular acidification rate (ECAR), and increasing oxygen consumption rate (OCR) in hepatoma cells.	Oxygen	187-193	insulin-like growth factor I receptor	Mus musculus	23-29
29485847-10	2018	Recent developments in designing various functional surfaces, such as self-assembled monolayers, gold nanostructures, and nanostructured semiconductors for facilitating electron transfer from specific enzymes, including superoxide dismutase (SOD), and further application to an O2 - biosensor are summarized.	Oxygen	278-280	superoxide dismutase 1	Homo sapiens	220-240
29485847-10	2018	Recent developments in designing various functional surfaces, such as self-assembled monolayers, gold nanostructures, and nanostructured semiconductors for facilitating electron transfer from specific enzymes, including superoxide dismutase (SOD), and further application to an O2 - biosensor are summarized.	Oxygen	278-280	superoxide dismutase 1	Homo sapiens	242-245
29356324-1	2018	Starting from NO-bound heme, the first step in converting NO into benign NO3- is the ligand exchange reaction FeNO+O2  FeO2 +NO, which is still poorly understood at a molecular level.	Oxygen	115-117	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
29392823-4	2018	Insights into the O2 binding pathway reveals the presence of a novel [(l+d)-PF-Cu3+ -O2- ] species, which can efficiently reduce ferric cytochrome c with the reactive O2- by receiving an electron from reductant ascorbic acid.	Oxygen	18-20	cytochrome c, somatic	Homo sapiens	136-148
29392823-4	2018	Insights into the O2 binding pathway reveals the presence of a novel [(l+d)-PF-Cu3+ -O2- ] species, which can efficiently reduce ferric cytochrome c with the reactive O2- by receiving an electron from reductant ascorbic acid.	Oxygen	85-87	cytochrome c, somatic	Homo sapiens	136-148
29514032-1	2018	Familial erythrocytosis with elevated erythropoietin levels is frequently caused by mutations in genes that regulate oxygen-dependent transcription of the gene encoding erythropoietin ( EPO).	Oxygen	117-123	erythropoietin	Homo sapiens	38-52
29514032-1	2018	Familial erythrocytosis with elevated erythropoietin levels is frequently caused by mutations in genes that regulate oxygen-dependent transcription of the gene encoding erythropoietin ( EPO).	Oxygen	117-123	erythropoietin	Homo sapiens	169-183
29514032-1	2018	Familial erythrocytosis with elevated erythropoietin levels is frequently caused by mutations in genes that regulate oxygen-dependent transcription of the gene encoding erythropoietin ( EPO).	Oxygen	117-123	erythropoietin	Homo sapiens	186-189
29965460-3	2018	The research presented here is, therefore, based on an areal hypolimnetic oxygen demand (AHOD) model to address three key themes related to the sediment oxygen demand (SOD):(1) the characteristics of sediment and its influences on SOD; (2) evaluation of SOD with different turbulence levels overlying the sediment; and (3) the influence of microbial metabolic activity on SOD.	Oxygen	74-80	superoxide dismutase 1	Homo sapiens	168-171
29965460-3	2018	The research presented here is, therefore, based on an areal hypolimnetic oxygen demand (AHOD) model to address three key themes related to the sediment oxygen demand (SOD):(1) the characteristics of sediment and its influences on SOD; (2) evaluation of SOD with different turbulence levels overlying the sediment; and (3) the influence of microbial metabolic activity on SOD.	Oxygen	153-159	superoxide dismutase 1	Homo sapiens	168-171
29371097-2	2018	We tested the hypothesis that activation of Akt would decrease infarct size and improve microregional O2 supply/consumption balance after cerebral ischemia-reperfusion.	Oxygen	102-104	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
29371097-14	2018	These results suggest that early Akt activation is important for not only cell survival, but also for the control of local oxygen balance after cerebral ischemia-reperfusion.	Oxygen	123-129	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
29509794-9	2018	Moreover, we showed that expression of DmHsp22 in transiently transfected HeLa cells increased maximal mitochondrial oxygen consumption capacity and ATP contents, providing a mechanistic link between DmHsp22 and mitochondrial functions.	Oxygen	117-123	Heat shock protein 22	Drosophila melanogaster	39-46
29509701-2	2018	The mTOR has a central converging role for many cell functions, serving as a sensor for extracellular signals from energy status and nutrients availability, growth factors, oxygen and stress.	Oxygen	173-179	mechanistic target of rapamycin kinase	Homo sapiens	4-8
29560463-5	2018	A compelling hypothesis for the evolution of a heterodimeric Type I reaction centre is that the gene duplication that allowed the divergence of PsaA and PsaB was an adaptation to incorporate photoprotective mechanisms against the formation of reactive oxygen species, therefore occurring after the origin of water oxidation to oxygen.	Oxygen	252-258	fatty acid amide hydrolase	Homo sapiens	153-157
29285833-3	2018	The importance of oxygen-dependent and ubiquitin-mediated proteolysis of the regulatory subunit of HIF-1 (HIF-1alpha) was first reported in 1997.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
29507344-9	2018	Physiological relevance of our findings was asserted in a mouse model of oxygen-induced retinopathy, where the beneficial anti-angiogenic properties of CLCF1 were abrogated when co-administrated with VLDL, indicating, that CLCF1 binds purified lipoproteins or lipoproteins in physiological fluids such as serum and behave as a "lipocytokine".	Oxygen	73-79	CD320 antigen	Mus musculus	200-204
29515645-8	2018	Capillary leakage was increased in the lungs of the animals in the vasopressin group compared to that in the lungs of animals in the RLB group (p &lt; 0.05); this increase was associated with the lowest partial pressure of oxygen (p &lt; 0.05).	Oxygen	223-229	arginine vasopressin	Rattus norvegicus	67-78
29212791-6	2018	Using pressure-volume assessments, males exposed to LPS/O2 had more pronounced contractile deficiencies than similarly exposed females, but females tended to have long PR intervals.	Oxygen	56-58	toll-like receptor 4	Mus musculus	52-55
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-151
29315872-2	2018	Oxygen activation by DNICs has been implicated as a possible route for protein tyrosine nitration (PTN), which leads to neurodegenerative disorders.	Oxygen	0-6	pleiotrophin	Homo sapiens	99-102
29315872-10	2018	Our report also sheds light on the plausible mechanistic pathway of PTN by reactive species formed once O2 activation by DNICs have been achieved.	Oxygen	104-106	pleiotrophin	Homo sapiens	68-71
29285833-3	2018	The importance of oxygen-dependent and ubiquitin-mediated proteolysis of the regulatory subunit of HIF-1 (HIF-1alpha) was first reported in 1997.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
29285833-4	2018	Since then, accumulating evidence has shown that HIF-1alpha may become stable and active even under normoxic conditions; for example, when disease-associated genetic and functional alterations in some genes trigger the aberrant activation of HIF-1 regardless of oxygen conditions.	Oxygen	262-268	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
29285833-4	2018	Since then, accumulating evidence has shown that HIF-1alpha may become stable and active even under normoxic conditions; for example, when disease-associated genetic and functional alterations in some genes trigger the aberrant activation of HIF-1 regardless of oxygen conditions.	Oxygen	262-268	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
29285833-5	2018	We herein review the last two decades of knowledge, since 1997, on the regulatory mechanisms of HIF-1 activity from conventional oxygen- and proteolysis-dependent mechanisms to up-to-the-minute information on cancer-associated genetic and functional alteration-mediated mechanisms.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
29211505-4	2018	Dietary nitrate (NO3-) supplementation has been shown to lower the O2 consumption in various conditions.	Oxygen	67-69	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29247929-4	2018	However, the photocatalytic fuel cell was still able to perform 37% of decolorization in a slow rate (k = 0.033 h-1) under extremely low dissolved oxygen concentration (approximately 0.2 mg L-1) when nitrogen gas was introduced into the fuel cell throughout the 8 h. However, the change of the UV-Vis spectrum indicates that the intermediates of the dye could not be mineralized under insufficient dissolved oxygen level.	Oxygen	147-153	immunoglobulin kappa variable 1-16	Homo sapiens	190-193
29456694-5	2018	Analyses for correlation showed a caspase-3 positive area that was positively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P&lt;0.05); and a Bcl-2 expression level that was negatively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P&lt;0.05).	Oxygen	94-100	caspase 3	Homo sapiens	34-43
29456694-5	2018	Analyses for correlation showed a caspase-3 positive area that was positively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P&lt;0.05); and a Bcl-2 expression level that was negatively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P&lt;0.05).	Oxygen	115-121	caspase 3	Homo sapiens	34-43
29337249-3	2018	HIF-1 induces genes involved in glucose metabolism and regulates cellular oxygen homeostasis.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
29253610-10	2018	SNP rs7656411*TLR2 was associated with length of oxygen use; SNPs rs352162*TLR9, rs187084*TLR9, and rs2280788*CCL5 were associated with requirement for intensive care unit admission; while SNPs rs1927911*TLR4, rs352162*TLR9, and rs2107538*CCL5 were associated with the need for mechanical ventilation.	Oxygen	49-55	toll like receptor 2	Homo sapiens	14-18
29393397-0	2018	Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor-1alpha.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-181
29447889-6	2018	RESULTS: Patients with higher respiratory related index or lower mean/lowest oxygen saturation of PSG showed smaller z-score for height.	Oxygen	77-83	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	98-101
29393397-2	2018	The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-alpha (HIF-1alpha) subunit.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-189
29393397-2	2018	The aim of this study was to validate the use of oxygen nanobubble water to overcome resistance to radiation in cancer cell lines via the suppression of the hypoxia-inducible factor 1-alpha (HIF-1alpha) subunit.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
29393397-11	2018	This newly created single-nanometer range oxygen nanobubble water, without any additives, may thus prove to be a promising agent which may be used to overcome the hypoxia-induced resistance of cancer cells to radiation via the suppression of HIF-1alpha.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	242-252
28942242-3	2018	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric protein, part of the basic helix-loop-helix family and one of the main regulators of cellular responses in a low-oxygen environment.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
29175739-0	2018	One-pot aqueous fabrication of reduced graphene oxide supported porous PtAg alloy nanoflowers to greatly boost catalytic performances for oxygen reduction and hydrogen evolution.	Oxygen	138-144	rhomboid domain containing 3	Homo sapiens	71-75
29110300-19	2018	Thus, the putative relationship between PLIN5 and insulin sensitivity is at best indirect and is apparent only in conjunction with maximal oxygen uptake.	Oxygen	139-145	perilipin 5	Homo sapiens	40-45
29110300-19	2018	Thus, the putative relationship between PLIN5 and insulin sensitivity is at best indirect and is apparent only in conjunction with maximal oxygen uptake.	Oxygen	139-145	insulin	Homo sapiens	50-57
29519422-3	2018	Plasma functionalized (N2 and O2) and stabilized Graphene Oxide (GO) thin layers in a hybrid with amorphous carbon (aC) induced the expression of vascular endothelial growth factor (VEGF) and osteoprotegerin (OPG) growth factors in fibroblasts (hGF) and, more remarkably, in osteoblasts (hFOB) cells confirming the suitability for tissue regeneration and osteo-integration applications.	Oxygen	30-32	vascular endothelial growth factor A	Homo sapiens	146-180
29519422-3	2018	Plasma functionalized (N2 and O2) and stabilized Graphene Oxide (GO) thin layers in a hybrid with amorphous carbon (aC) induced the expression of vascular endothelial growth factor (VEGF) and osteoprotegerin (OPG) growth factors in fibroblasts (hGF) and, more remarkably, in osteoblasts (hFOB) cells confirming the suitability for tissue regeneration and osteo-integration applications.	Oxygen	30-32	vascular endothelial growth factor A	Homo sapiens	182-186
29421238-6	2018	Furthermore, inhibition of extracellular O2 - by overexpression of ECSOD or alteration of the extracellular Cys/CySS ratio by knockdown of xCT protein inhibited PCa cell invasion.	Oxygen	41-43	superoxide dismutase 3	Homo sapiens	67-72
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	vascular endothelial growth factor A	Homo sapiens	19-53
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	vascular endothelial growth factor A	Homo sapiens	55-59
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	fibroblast growth factor 2	Homo sapiens	62-92
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	fibroblast growth factor 2	Homo sapiens	94-98
28942242-3	2018	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric protein, part of the basic helix-loop-helix family and one of the main regulators of cellular responses in a low-oxygen environment.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
29065215-7	2018	Gene expression experiments showed that, apart from the conventional nitrogen catabolic repression mechanism that is operating in aerobiosis, there seems to be an oxygen-independent mechanism acting to overexpress key genes like GAP1, GDH1, GDH2 and GLT1 to ensure adequate anaerobic growth even in the presence of non-preferential nitrogen source.	Oxygen	163-169	amino acid permease GAP1	Saccharomyces cerevisiae S288C	229-233
29411604-0	2018	Fe Stabilization by Intermetallic L10-FePt and Pt Catalysis Enhancement in L10-FePt/Pt Nanoparticles for Efficient Oxygen Reduction Reaction in Fuel Cells.	Oxygen	115-121	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	34-37
29322561-2	2018	In this study, an oxygen-generating scaffold was fabricated to prevent hypoxic cell damage and improve the viability and insulin secretion of islets.	Oxygen	18-24	insulin	Homo sapiens	121-128
29411604-0	2018	Fe Stabilization by Intermetallic L10-FePt and Pt Catalysis Enhancement in L10-FePt/Pt Nanoparticles for Efficient Oxygen Reduction Reaction in Fuel Cells.	Oxygen	115-121	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	75-78
29507732-7	2018	Results: Linear mixed models showed that the maximal oxygen uptake increased by 1.1 mL kg-1 min- 1 during the rehabilitation program and by 3.7 mL kg-1 min- 1 at one-year follow-up.	Oxygen	53-59	CD59 molecule (CD59 blood group)	Homo sapiens	92-98
29407982-4	2018	Docking studies revealed the capacity of this compound to occupy the selective COX-2 cavity establishing additional hydrogen bonds between the oxygen of the methoxy group and the His90 and Arg513 of the binding site of the enzyme.	Oxygen	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
29507732-7	2018	Results: Linear mixed models showed that the maximal oxygen uptake increased by 1.1 mL kg-1 min- 1 during the rehabilitation program and by 3.7 mL kg-1 min- 1 at one-year follow-up.	Oxygen	53-59	CD59 molecule (CD59 blood group)	Homo sapiens	152-158
29600135-9	2018	Similar interactions of oxygen vacancies existing on the TiO2 surface with SP1 and SP2 were observed.	Oxygen	24-30	Sp2 transcription factor	Homo sapiens	83-86
29266939-1	2018	Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of chemically inert carbon-hydrogen bonds in diverse endogenous and exogenous organic compounds by atmospheric oxygen.	Oxygen	26-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
29266939-1	2018	Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of chemically inert carbon-hydrogen bonds in diverse endogenous and exogenous organic compounds by atmospheric oxygen.	Oxygen	26-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
29594649-1	2018	Gold nanoclusters (AuNCs) capped with lipoic acid (LA) or templated with bovine serum albumin (BSA) are shown to be viable fluorescent probes for oxygen (O2) which acts as a collisional quencher.	Oxygen	146-152	albumin	Homo sapiens	80-93
29577109-2	2018	Recent work demonstrated that cells lacking NLRX1 have higher oxygen consumption but lower levels of adenosine triphosphate, suggesting that NLRX1 might prevent uncoupling of oxidative phosphorylation.	Oxygen	62-68	NLR family member X1	Mus musculus	44-49
29434038-0	2018	Poldip2 is an oxygen-sensitive protein that controls PDH and alphaKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.	Oxygen	14-20	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	53-56
28994107-6	2018	Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts.	Oxygen	62-64	snail family transcriptional repressor 1	Homo sapiens	115-120
29449553-1	2018	Vascular endothelial growth factor A (VEGF-A), a fundamental component of angiogenesis, provides nutrients and oxygen to solid tumors, and enhances tumor cell survival, invasion, and migration.	Oxygen	111-117	vascular endothelial growth factor A	Homo sapiens	0-36
29449553-1	2018	Vascular endothelial growth factor A (VEGF-A), a fundamental component of angiogenesis, provides nutrients and oxygen to solid tumors, and enhances tumor cell survival, invasion, and migration.	Oxygen	111-117	vascular endothelial growth factor A	Homo sapiens	38-44
29131928-1	2018	RATIONALE: The nitrogen and oxygen (delta15 N, delta18 O, delta17 O) isotopic compositions of NO3- and NO2- are important tracers of nutrient dynamics in soil, rain, groundwater and oceans.	Oxygen	28-34	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
29643975-4	2018	In this study, we found that physiological hypoxia (10% O2) enhanced the stemness properties and promoted the proliferation ability of iHepSCs by accelerating G1/S transition via p53-p21 signaling pathway.	Oxygen	56-58	tumor protein p53	Homo sapiens	179-182
29594649-1	2018	Gold nanoclusters (AuNCs) capped with lipoic acid (LA) or templated with bovine serum albumin (BSA) are shown to be viable fluorescent probes for oxygen (O2) which acts as a collisional quencher.	Oxygen	154-156	albumin	Homo sapiens	80-93
29378948-1	2018	The oncoprotein c-Myc plays an important role in regulating glycolysis under normoxia; yet, in cancer cells, HIF1alpha, which is essential for driving glycolysis under hypoxia, is often up-regulated even in the presence of oxygen.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-118
29416029-8	2018	Serial truncation and point mutation of Ngb revealed that the 7-105 aa fragment of Ngb was required and the oxygen-binding site (His64) of Ngb was the major regulatory site for its p38 interaction/activation.	Oxygen	108-114	mitogen-activated protein kinase 14	Homo sapiens	181-184
29434188-8	2018	Analysis of mitochondrial functions in G2019S Lrrk2-expressing SH-SY5Y cells revealed strong rotenone-induced oxidative stress characterized by reduced Ca2+ buffering capability and ATP synthesis, production of reactive oxygen species, and increased mitochondrial fragmentation.	Oxygen	220-226	leucine rich repeat kinase 2	Homo sapiens	46-51
29507904-10	2018	Moreover, expression of hepatocyte nuclear factor 4alpha (Hnf4alpha) and farnesoid X receptor (Fxr) were better preserved in shaken cultures as a result of improved oxygen delivery.	Oxygen	165-171	nuclear receptor subfamily 1, group H, member 4	Mus musculus	95-98
29452577-12	2018	Poldip2 expression was upregulated in astrocytes exposed to oxygen and glucose deprivation (OGD) and siRNA-mediated downregulation of Poldip2 abrogated OGD-induced IL-6 and TNF-alpha expression.	Oxygen	60-66	interleukin 6	Mus musculus	164-168
29682321-4	2018	Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx.	Oxygen	14-20	lysine demethylase 6A	Homo sapiens	55-58
29121425-5	2018	The BF2 nbm dye (1) was substituted with Br on naphthyl (2), phenyl (3), or both rings (4) to tailor the fluorescence/phosphorescence ratio and RTP lifetime-important features for designing O2 sensing dyes by means of the heavy atom effect.	Oxygen	190-192	forkhead box G1	Homo sapiens	4-7
29682321-4	2018	Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx.	Oxygen	14-20	lysine demethylase 6A	Homo sapiens	74-77
29682321-4	2018	Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx.	Oxygen	14-20	lysine demethylase 6A	Homo sapiens	74-77
29682321-4	2018	Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx.	Oxygen	14-20	lysine demethylase 6A	Homo sapiens	74-77
29682321-4	2018	Comparison of oxygen saturation values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx.	Oxygen	14-20	lysine demethylase 6A	Homo sapiens	74-77
29222974-8	2018	We also demonstrated that cytosolic hydrogen peroxide, formed by O2- dismutation, act as an intracellular messenger to specifically activate the Trk/Ras/ERK signaling pathway.	Oxygen	65-67	mitogen-activated protein kinase 1	Homo sapiens	153-156
29120493-1	2018	BACKGROUND: One mechanism by which alcoholic liver disease (ALD) progresses is oxidative stress and the generation of reactive oxygen species, among others due to the induction of cytochrome P-4502E1 (CYP2E1).	Oxygen	127-133	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	180-199
29120493-1	2018	BACKGROUND: One mechanism by which alcoholic liver disease (ALD) progresses is oxidative stress and the generation of reactive oxygen species, among others due to the induction of cytochrome P-4502E1 (CYP2E1).	Oxygen	127-133	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	201-207
29130578-8	2018	Notably, mitochondrially targeted p53 (mito-p53) directly reduced mitochondria DNA-encoded ND2 and ND4 gene expression resulting in increased reactive oxygen species (ROS) and reduced mitochondrial oxygen consumption.	Oxygen	151-157	tumor protein p53	Homo sapiens	34-37
29130578-8	2018	Notably, mitochondrially targeted p53 (mito-p53) directly reduced mitochondria DNA-encoded ND2 and ND4 gene expression resulting in increased reactive oxygen species (ROS) and reduced mitochondrial oxygen consumption.	Oxygen	151-157	tumor protein p53	Homo sapiens	44-47
29130578-11	2018	SIRT3 overexpression restored the expression of ND2 and ND4 and improved mitochondrial oxygen consumption by repressing mito-p53 activity.	Oxygen	87-93	sirtuin 3	Homo sapiens	0-5
29155105-8	2018	Cygb and aMb1 have high O2 affinity and nitrite reductase activity, while the two hemoglobins display low O2 affinity and nitrite reductase activity.	Oxygen	24-26	cytoglobin	Homo sapiens	0-4
29155105-9	2018	Cygb and aHb6 but not aHb5a show cooperative O2 binding, correlating with increased stability of dimers, as shown by gel filtration and molecular modeling.	Oxygen	45-47	cytoglobin	Homo sapiens	0-4
29155105-11	2018	The dimeric structure and O2-binding properties of sea lamprey and mammalian Cygb were very similar, suggesting a conservation of function since their divergence around 500million years ago.	Oxygen	26-28	cytoglobin	Homo sapiens	77-81
29186390-1	2018	Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen, and insulin to muscle.	Oxygen	98-104	angiotensinogen	Rattus norvegicus	0-14
29254050-4	2018	The experimental results indicated that the well-kept MMT@CPF after embedding in the EVOH matrix significantly improved the thermal stability and mechanical properties of the film, and also endowed the film with outstanding oxygen barrier (0.2x10-16cm3cmcm-2s-1Pa-1) and good moisture barrier (4.6x10-6gmm-2s-1atm-1 under a relative humidity of 90%) by prolonging the tortuous paths for molecule penetration.	Oxygen	224-230	nuclear receptor subfamily 5 group A member 2	Homo sapiens	58-61
29396728-5	2018	Our study demonstrates an oxygen- and prolyl hydroxylase-independent regulation of HIF-1alpha by P-AscH-.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
29366441-5	2018	We have observed the overexpression of the hypoxia-inducible factor 1 (HIF-1), an essential factor for oxygen homeostasis, in the epithelium of sinus mucosa in sinusitis patients.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-69
29366441-5	2018	We have observed the overexpression of the hypoxia-inducible factor 1 (HIF-1), an essential factor for oxygen homeostasis, in the epithelium of sinus mucosa in sinusitis patients.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
29070584-5	2018	MiR-130a overexpression induced by miR-130a mimic increased monolayer permeability, and intercellular inhibition of miR-130a by a miR-130a inhibitor suppressed oxygen-glucose deprivation-induced increase in monolayer permeability.	Oxygen	160-166	microRNA 130a	Rattus norvegicus	0-8
29070584-5	2018	MiR-130a overexpression induced by miR-130a mimic increased monolayer permeability, and intercellular inhibition of miR-130a by a miR-130a inhibitor suppressed oxygen-glucose deprivation-induced increase in monolayer permeability.	Oxygen	160-166	microRNA 130a	Rattus norvegicus	35-43
29070584-5	2018	MiR-130a overexpression induced by miR-130a mimic increased monolayer permeability, and intercellular inhibition of miR-130a by a miR-130a inhibitor suppressed oxygen-glucose deprivation-induced increase in monolayer permeability.	Oxygen	160-166	microRNA 130a	Rattus norvegicus	116-124
29070584-5	2018	MiR-130a overexpression induced by miR-130a mimic increased monolayer permeability, and intercellular inhibition of miR-130a by a miR-130a inhibitor suppressed oxygen-glucose deprivation-induced increase in monolayer permeability.	Oxygen	160-166	microRNA 130a	Rattus norvegicus	116-124
29278949-4	2018	The results presented herein show that highly concentrated solutions of bovine serum albumin (BSA) exposed to peroxynitrite, or metmyoglobin/H2O2, initiate the formation and propagation of protein peroxyl radicals, as evidenced by oxygen consumption, fluorescence spectroscopy, chemiluminescence, and electron paramagnetic resonance studies.	Oxygen	231-237	albumin	Homo sapiens	79-92
28600879-5	2018	IFN-gamma priming provoked ROS elevation, cell growth slowdown, attenuation of both spontaneous and induced osteodifferentiation of tissue O2 -adapted ASCs.	Oxygen	139-141	interferon gamma	Homo sapiens	0-9
29327348-9	2018	RESULTS: Kcna1-/- mice experienced an increase in basal respiratory drive, chronic oxygen desaturation, frequent apnea-hypopnea (A-H), an atypical breathing sequence of A-H-tachypnea-A-H, increased tidal volume, and hyperventilation induced by MCh.	Oxygen	83-89	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	9-14
28600879-12	2018	Thus, this study first demonstrated that IFN-gamma priming itself and in combination with acute O2 deprivation could supply dual effects on ASC functions providing both stimulatory and hampering effects.	Oxygen	96-98	PYD and CARD domain containing	Homo sapiens	140-143
28865129-8	2018	The 5% oxygen atmosphere did not influence cell proliferation, but enhanced slightly ACAN and COL2A1 gene expression.	Oxygen	7-13	collagen type II alpha 1 chain	Homo sapiens	94-100
29070768-0	2018	Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study.	Oxygen	72-78	growth hormone 1	Homo sapiens	10-24
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Oxygen	73-79	NLR family pyrin domain containing 3	Homo sapiens	183-188
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Oxygen	73-79	caspase 1	Homo sapiens	201-210
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Oxygen	73-79	interleukin 1 beta	Homo sapiens	224-232
29227471-5	2018	Inhibition of Mir1 by ML316 in respiring yeast diminished mitochondrial oxygen consumption, resulting in an unusual metabolic catastrophe marked by citrate accumulation and death.	Oxygen	72-78	Mir1p	Saccharomyces cerevisiae S288C	14-18
29067740-8	2018	Intravitreal injected ASC SH-NOTCH2 in oxygen-induced retinopathy mouse eyes did not engraft in the preexisting retinal microvasculature.	Oxygen	39-45	PYD and CARD domain containing	Homo sapiens	22-25
29308820-3	2018	The S-nitrosylation detection and subsequent kinetic investigations into the arachidonic acid (AA) oxidation of COX enzymes indicate that NO S-nitrosylates both COX-1 and COX-2 in an oxygen-dependent manner, but enhances only the dioxygenase activity of COX-2.	Oxygen	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	Oxygen	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29146540-5	2018	Furthermore, after treated with ROSP@MSN@DOX at a concentration of 100 mug/mL for 24 h, the viability of Hela cells is reduced to 40.5%; Control experiments demonstrate that, when Hela cells are pretreated with active oxygen scavenger, cell viability is about 65.3% due to the significant decrease of intracellular reactive oxygen species.	Oxygen	218-224	moesin	Homo sapiens	32-40
29246543-2	2018	Classically, expression and activity of HIF1-alpha is regulated by oxygen-concentration within cell.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-87
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-94
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-161
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-161
29105714-0	2018	Oxygen induced enhancement of NIR emission in brookite TiO2 powders: comparison with rutile and anatase TiO2 powders.	Oxygen	0-6	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	30-33
29105714-5	2018	However, exposure to O2 shows curious behaviors: the visible emission was quenched but the NIR emission was enhanced.	Oxygen	21-23	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	91-94
29105714-9	2018	The O2 adsorption promotes the hole accumulation at the surface and then assists the recombination of these deeply trapped electrons, resulting in the enhancement of the NIR emission.	Oxygen	4-6	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	170-173
29070768-3	2018	This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry.	Oxygen	94-100	growth hormone 1	Homo sapiens	34-48
29351198-5	2018	The current study demonstrates that the Mn(II)-containing pentaazamacrocyclic selective SOD mimetic GC4419 may serve as an AscH-/O2 - oxidoreductase as evidenced by the increased rate of oxygen consumption, steady-state concentrations of ascorbate radical, and H2O2 production in complete cell culture media.	Oxygen	187-193	superoxide dismutase 1	Homo sapiens	88-91
29360776-0	2018	Involvement of Bradykinin B2 Receptor in Pathological Vascularization in Oxygen-Induced Retinopathy in Mice and Rabbit Cornea.	Oxygen	73-79	kininogen 1	Homo sapiens	15-25
29581926-5	2018	While using morphine and oxygen is associated with risks such as higher mortality and increase in the size of the infarct, respectively, several available drugs such as fibrinolytics, anticoagulants, beta-blockers, renin-angiotensin-aldosterone system inhibitors, P2Y12 inhibitors, and statins are known to be useful to treat ACS.	Oxygen	25-31	renin	Homo sapiens	215-220
29218809-3	2018	Such trimetallic cluster has proved to be a suitable platform for developing the unprecedented non-redox rare-earth-mediated oxygen atom transfer from ketones to CS2 and PhNCS.	Oxygen	125-131	chorionic somatomammotropin hormone 2	Homo sapiens	162-165
29497482-11	2017	In MDA-MB-231 cells high fractional oxygen increased secretion of angiogenesis factors monocyte chemotactic protein 1, regulated on activation normal T-cell expressed and vascular endothelial growth factor.	Oxygen	36-42	vascular endothelial growth factor A	Homo sapiens	171-205
29497482-12	2017	In MCF-7 cells, interleukin-8, angiogenin and vascular endothelial growth factor secretion was significantly increased by high fractional oxygen.	Oxygen	138-144	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
29497482-12	2017	In MCF-7 cells, interleukin-8, angiogenin and vascular endothelial growth factor secretion was significantly increased by high fractional oxygen.	Oxygen	138-144	vascular endothelial growth factor A	Homo sapiens	46-80
29128627-0	2018	Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and glucose deprivation and reoxygenation.	Oxygen	81-87	Janus kinase 1	Homo sapiens	14-18
29403357-4	2018	Here we show for the first time that normal rat birth is also accompanied by an AVP surge, and that the fetal AVP surge is further enhanced in a model of birth asphyxia, based on exposing 6-day old rat pups to a gas mixture containing 4% O2 and 20% CO2 for 45 min.	Oxygen	238-240	arginine vasopressin	Rattus norvegicus	110-113
29346761-5	2018	Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status.	Oxygen	51-57	chromatin-remodeling ATPase INO80	Saccharomyces cerevisiae S288C	14-19
29298355-7	2018	In plants treated with HpaXm35-51 or Hpa1Xoo36-52, the expression of the HR marker genes Hin1 and Hsr203J and the active oxygen metabolism related gene AOX were significantly upregulated.	Oxygen	121-127	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	152-155
29242061-8	2018	If one considers that S340E mutation enhances Nox1 activation (Kaito et al., 2014), the present study suggests that betaPix can also play an inhibitory role in O2- production, depending on the sites of phosphorylation.	Oxygen	160-162	Rho guanine nucleotide exchange factor 7	Homo sapiens	116-123
29576854-7	2018	An increase in cell death after Abeta peptide treatment or irradiation was unexpectedly restored to the control level or below when both were combined, particularly at 5% O2.	Oxygen	171-173	amyloid beta precursor protein	Homo sapiens	32-37
29158339-7	2018	Finally, Ccr4 and Dhh1 associate with mRNAs whose abundance increases during nutrient starvation, and those that fluctuate during metabolic and oxygen consumption cycles, which explains the known genetic connections between these factors and nutrient utilization and stress pathways.	Oxygen	144-150	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	18-22
29850654-1	2018	Superoxide dismutase 1 (SOD1) is a metalloenzyme that catalyzes the disproportionation of superoxide into molecular oxygen and hydrogen peroxide.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	0-22
29035674-3	2018	During the acclimation process, the chemical oxygen demand (COD) of MSIW gradually increased from 0 to 2,000 mg L-1, and the COD removal finally reached 90%.	Oxygen	45-51	immunoglobulin kappa variable 1-16	Homo sapiens	112-115
29850654-1	2018	Superoxide dismutase 1 (SOD1) is a metalloenzyme that catalyzes the disproportionation of superoxide into molecular oxygen and hydrogen peroxide.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	24-28
29178490-4	2018	The oxygen vacancy in PrNPs increases the metal reactivity to anchor LiPSs, and co-existence of lithiophilic (O) and sulfiphilic (Sr) sites in PrNP favor the dual-bonding (Li O and Sr S bonds) to anchor LiPSs.	Oxygen	4-10	prion protein	Homo sapiens	22-26
30178379-3	2018	Published experimental work with rhodopsin and bacteriorhodopsin has led to the hypothesis that integral proteins lessen membrane oxygen permeability, as well as the permeability of the lipid region.	Oxygen	130-136	rhodopsin	Homo sapiens	33-42
30178315-8	2018	Angioplasticity is primarily regulated through the hypoxia inducible transcription factor, acting as a detector of the balance between oxygen delivery and energy demand at the level of the cell redox state, controlling vascular endothelial growth factor production which helps determine capillary density in consort with the cyclooxygenase-2/angiopoietin-2 pathway that controls endothelial cell junction mechanical stability.	Oxygen	135-141	vascular endothelial growth factor A	Homo sapiens	219-253
30178315-8	2018	Angioplasticity is primarily regulated through the hypoxia inducible transcription factor, acting as a detector of the balance between oxygen delivery and energy demand at the level of the cell redox state, controlling vascular endothelial growth factor production which helps determine capillary density in consort with the cyclooxygenase-2/angiopoietin-2 pathway that controls endothelial cell junction mechanical stability.	Oxygen	135-141	prostaglandin-endoperoxide synthase 2	Homo sapiens	325-341
29199120-5	2018	Oxygen affinity was evaluated by measuring p50 values in distinct pHs (Bohr effect), and the heme-heme cooperativity was analyzed by determining the Hill coefficient (n), in addition to the effect of the allosteric effectors inositol hexaphosphate (IHP) and 2,3-bisphosphoglyceric acid (2,3-BPG).	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	43-46
30450978-3	2018	In the absence of protective enzymes (superoxide dismutase (SOD) and catalase (CAT)) Hb is oxidized to MetHb and thus losing its function of oxygen delivery.	Oxygen	141-147	superoxide dismutase 1	Homo sapiens	38-58
29191924-7	2018	Moreover, the expressions of HB-EGF and VEGF were increased after laser-induced CNV and oxygen-induced retinopathy, and their expression sites were located around the neovascular areas.	Oxygen	88-94	vascular endothelial growth factor A	Homo sapiens	40-44
30450978-3	2018	In the absence of protective enzymes (superoxide dismutase (SOD) and catalase (CAT)) Hb is oxidized to MetHb and thus losing its function of oxygen delivery.	Oxygen	141-147	superoxide dismutase 1	Homo sapiens	60-63
29317401-8	2018	Although acute FSTL1 administration caused minimal hemodynamic changes at baseline, in HF dogs it enhanced cardiac oxygen consumption and transiently reversed the changes in free fatty acid and glucose oxidation and systemic respiratory quotient.	Oxygen	115-121	follistatin like 1	Canis lupus familiaris	15-20
29287673-6	2018	RESULTS: At oxygen flow rate of 5L.min-1, time to reach EtO2&gt;=90% was significantly longer with Bain"s system (3.7+-0.67min) than Mapleson A and Circle system (2.9+-0.6, 3.3+-0.97min, respectively).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
29287673-7	2018	However at oxygen flow rate of 10L.min-1 this time was significantly shorter and comparable among all the three breathing systems (2.33+-0.38min with Mapleson, 2.59+-0.50min with Bain"s and 2.60+-0.47min with Circle system).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
29287673-8	2018	CONCLUSIONS: With spontaneous normal tidal volume breathing at oxygen flow rate of 5L.min-1, Mapleson A can optimally preoxygenate patients within 3min while Bain"s and Circle system require more time.	Oxygen	63-69	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
29287673-9	2018	However at O2 flow rate of 10L.min-1 all the three breathing systems are capable of optimally preoxygenating the patients in less than 3min.	Oxygen	11-13	CD59 molecule (CD59 blood group)	Homo sapiens	31-36
29990992-7	2018	T3 significantly enhanced complex I (+145% vs. Hypo), complex II (+66% vs. Hypo), and glycerol-3 phosphate dehydrogenase (G3PDH)-linked oxygen consumptions (about 6- fold those obtained in Hypo), while 3,5-T2 administration selectively restored Euthyroid values of complex II- and increased G3PDH- linked respiratory pathways (+165% vs. Hypo).	Oxygen	136-142	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	86-120
29990992-7	2018	T3 significantly enhanced complex I (+145% vs. Hypo), complex II (+66% vs. Hypo), and glycerol-3 phosphate dehydrogenase (G3PDH)-linked oxygen consumptions (about 6- fold those obtained in Hypo), while 3,5-T2 administration selectively restored Euthyroid values of complex II- and increased G3PDH- linked respiratory pathways (+165% vs. Hypo).	Oxygen	136-142	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	122-127
30930507-7	2018	This had a substantial influence on the main outflow of Windermere, the River Leven, where dissolved oxygen concentrations decreased by ~ 48%, from 9.3 to 4.8 mg L-1, while at the mid-lake monitoring station in Windermere, it decreased by only ~ 3%.	Oxygen	101-107	immunoglobulin kappa variable 1-16	Homo sapiens	162-165
29129693-6	2018	Mechanistically, FOXJ1 enhances glycolysis by increasing glucose uptake, lactate production and extracellular acidification rate (ECAR), and decreasing ATP generation and oxygen consumption rate (OCR) in bladder cancer cells.	Oxygen	171-177	forkhead box J1	Homo sapiens	17-22
29846435-10	2018	Trained groups with ACE-II and ACE-ID genotypes presented an increase in oxygen consumption (VO2VAT) and power output after the AIT program.	Oxygen	73-79	angiotensin I converting enzyme	Homo sapiens	20-23
29846435-10	2018	Trained groups with ACE-II and ACE-ID genotypes presented an increase in oxygen consumption (VO2VAT) and power output after the AIT program.	Oxygen	73-79	angiotensin I converting enzyme	Homo sapiens	31-34
29742494-2	2018	Hypoxia-inducible factor 1alpha (HIF-1alpha) is the key transcription factor in the response to oxygen deficiency in mammals.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
29742494-2	2018	Hypoxia-inducible factor 1alpha (HIF-1alpha) is the key transcription factor in the response to oxygen deficiency in mammals.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
29317401-11	2018	Complementary in vitro experiments in primary cardiac and skeletal muscle myocytes showed that FSTL1 stimulated oxygen consumption through AMPK (AMP-activated kinase) activation.	Oxygen	112-118	follistatin like 1	Canis lupus familiaris	95-100
29318974-4	2018	Owing to an energy and/or oxygen supply imbalance, different signaling mechanisms including MAPK/PI3K-Akt signaling pathways, glutamatergic synapse formation, and/or translocation of phosphatidylserine, might activate some central executing mechanism common to all these pathologies and also related to oxidative stress.	Oxygen	26-32	AKT serine/threonine kinase 1	Homo sapiens	102-105
28165799-14	2018	However, transcription of VEGF and ANG-1 was significantly higher at 2% oxygen than at 21% O2.	Oxygen	72-78	vascular endothelial growth factor A	Homo sapiens	26-30
28165799-14	2018	However, transcription of VEGF and ANG-1 was significantly higher at 2% oxygen than at 21% O2.	Oxygen	91-93	vascular endothelial growth factor A	Homo sapiens	26-30
28165799-15	2018	The optimum oxygen range at which hMSCs proliferated rapidly and angiogenic factors ANG-1 and VEGF simultaneously came to expression was from 1 to 2% oxygen.	Oxygen	12-18	vascular endothelial growth factor A	Homo sapiens	94-98
28165799-15	2018	The optimum oxygen range at which hMSCs proliferated rapidly and angiogenic factors ANG-1 and VEGF simultaneously came to expression was from 1 to 2% oxygen.	Oxygen	150-156	vascular endothelial growth factor A	Homo sapiens	94-98
30411685-5	2018	In normoxia condition HIF is inactivated by prolyl hydroxylase enzymes (EGLN 1-3, also known as PHD 1-3) using oxygen as a substrate.	Oxygen	111-117	egl-9 family hypoxia inducible factor 1	Homo sapiens	72-80
30411685-8	2018	The most studied factor is HIF-1 which is a heterodimer consisting of two forms, the form alpha is expressed in manner oxygen dependent, the form beta is expressed constitutively.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-32
29037940-0	2018	Hyperbaric oxygen treatment effects on in vitro cultured umbilical cord blood CD34+ cells.	Oxygen	11-17	CD34 molecule	Homo sapiens	78-82
29140411-9	2018	Steroidogenic stimuli such as Ang II and ACTH increase ABF to promote oxygen and cholesterol delivery for steroidogenesis and aldosterone transport to its target tissues.	Oxygen	70-76	angiotensinogen	Rattus norvegicus	30-36
29077919-4	2018	Our results showed that overexpressed miR-19b in stromal vascular fraction (SVF) cells derived from subcutaneous adipose tissue had the same effects as dexamethasone (DEX) treatment on the inhibition of adipose browning and oxygen consumption rate.	Oxygen	224-230	microRNA 19b-2	Mus musculus	38-45
29077919-5	2018	The inhibition of miR-19b blocked DEX-mediated suppression of the expression of browning marker genes as well as the oxygen consumption rate in differentiated SVF cells derived from subcutaneous and brown adipose tissue.	Oxygen	117-123	microRNA 19b-2	Mus musculus	18-25
28911884-3	2018	The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function.	Oxygen	197-203	vascular endothelial growth factor A	Homo sapiens	19-23
28911884-3	2018	The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function.	Oxygen	197-203	vascular endothelial growth factor A	Homo sapiens	139-143
29950791-7	2018	Above a vessel wall thickness of approximately 100 microm, hypoxia-induced factor (HIF-1alpha) is intensified by the lack of oxygen, which leads to an increase in growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
29121446-1	2018	von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1alpha in an oxygen-dependent manner.	Oxygen	131-137	VHL binding protein 1	Homo sapiens	0-35
29121446-1	2018	von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1alpha in an oxygen-dependent manner.	Oxygen	131-137	VHL binding protein 1	Homo sapiens	37-41
29121446-1	2018	von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1alpha in an oxygen-dependent manner.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
29121446-2	2018	HIF-1 is a key regulator of adaptive responses to a lack of oxygen that controls glucose metabolism, angiogenesis, proliferation, invasion, and metastasis.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
29950791-7	2018	Above a vessel wall thickness of approximately 100 microm, hypoxia-induced factor (HIF-1alpha) is intensified by the lack of oxygen, which leads to an increase in growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	187-221
29950791-7	2018	Above a vessel wall thickness of approximately 100 microm, hypoxia-induced factor (HIF-1alpha) is intensified by the lack of oxygen, which leads to an increase in growth factors, such as vascular endothelial growth factor (VEGF).	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	223-227
28990117-0	2018	Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-200
28990117-11	2018	MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
29236166-0	2018	Correction to: Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.	Oxygen	171-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-215
29115384-7	2018	Results from the Seahorse metabolic flux analyzer indicated that Ang II decreased basal oxygen consumption, maximal respiration capacity, spare respiration capacity, adenosine triphosphate-linked respiration and non-mitochondrial respiration.	Oxygen	88-94	angiotensinogen	Homo sapiens	65-71
28982945-5	2018	Before training, inhibition of PDE5 increased ( P < 0.05) skeletal muscle blood flow and O2 uptake during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training.	Oxygen	89-91	phosphodiesterase 5A	Homo sapiens	31-35
29115415-4	2018	In the present study, we used MCF7 breast cancer cells and confirmed that a combination of IFN-alpha/beta/gamma incubation induced STAT1/3 phosphorylation and mitochondria importation, which increased mitochondria respiratory complexes, the cellular oxygen consumption rate (OCR), and ROS production, followed by cellular apoptosis.	Oxygen	250-256	interferon alpha 1	Homo sapiens	91-100
28332183-6	2018	These results collectively suggest that RORalpha functions as an important mediator of HIF-1alpha activities in regulating keratinocyte differentiation/survival and epidermal barrier function during the oxygen sensing stage.	Oxygen	203-209	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
29061339-6	2018	We propose that HIC2 regulates a switching event within both the contractile machinery of cardiomyocytes and the oxygen carrying systems during the developmental period where demands on cardiac loading change rapidly.	Oxygen	113-119	HIC ZBTB transcriptional repressor 2	Homo sapiens	16-20
29132019-1	2018	Oxygen homeostasis in normal and tumor cells is mediated by hypoxia-inducible factors (HIFs), which are active as heterodimer complexes, such as HIF-2alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-1alpha-ARNT.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-224
29394390-0	2018	Reply to Comment "Nocturnal decrease of arterial oxygen content-hidden stimulus for erythropoietin secretion at altitude by Boning et al.	Oxygen	49-55	erythropoietin	Homo sapiens	84-98
29456269-11	2018	Overall, our data indicate that the abrupt change in O2 microdistribution caused by aggregates stimulates denitrification of NO3- from the overlying water, and loosens the coupling between benthic nitrification and denitrification both in time and space.	Oxygen	53-55	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
29232455-0	2018	Nocturnal decrease of arterial oxygen content-hidden stimulus for erythropoietin secretion at altitude.	Oxygen	31-37	erythropoietin	Homo sapiens	66-80
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	superoxide dismutase 2, mitochondrial	Mus musculus	86-89
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	catalase	Mus musculus	173-181
29372152-11	2018	On western blots, the expression of HIF-1alpha decreased significantly after treatment with estradiol under 3% O2 tension.	Oxygen	111-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
30097105-3	2018	Our previous work has shown that generating the critical, glycine-centered radical species on CutC requires posttranslational modification by an S-adenosyl-l-methionine (SAM)-dependent radical-activating protein (CutD) harboring an oxygen-sensitive [4Fe-4S] cofactor.	Oxygen	232-238	cutC copper transporter	Homo sapiens	94-98
29257198-0	2018	P2Y1 receptor antagonists mitigate oxygen and glucose deprivation-induced astrocyte injury.	Oxygen	35-41	purinergic receptor P2Y1	Rattus norvegicus	0-4
29257202-0	2018	Overexpression of microRNA-146 protects against oxygen-glucose deprivation/recovery-induced cardiomyocyte apoptosis by inhibiting the NF-kappaB/TNF-alpha signaling pathway.	Oxygen	48-54	tumor necrosis factor	Rattus norvegicus	144-153
29592784-0	2018	The analgesic effect of early hyperbaric oxygen treatment in chronic constriction injury rats and its influence on nNOS and iNOS expression and inflammatory factor production.	Oxygen	41-47	nitric oxide synthase 2	Rattus norvegicus	124-128
29562226-3	2018	This has led to the development of pharmacological agents for anti-angiogenesis to disrupt the vascular supply and starve the tumor of nutrients and oxygen, primarily through the blockade of VEGF/VEGF receptor signaling.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	191-195
29562226-3	2018	This has led to the development of pharmacological agents for anti-angiogenesis to disrupt the vascular supply and starve the tumor of nutrients and oxygen, primarily through the blockade of VEGF/VEGF receptor signaling.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	196-200
29380952-1	2018	Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment.	Oxygen	49-51	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29168340-7	2018	This oxygen-induced increase in paracellular leak was associated with altered claudin expression, where claudin-3 and -18 were downregulated at both the mRNA and protein level.	Oxygen	5-11	claudin 3	Rattus norvegicus	104-121
30451453-3	2018	In this study the optimal %DO (dissolved oxygen) and post induction temperature values for improved production of beta-NGF were found in the bioreactor scale using response surface methodology (RSM) as the most common statistical method.	Oxygen	41-47	nerve growth factor	Homo sapiens	114-122
29202233-1	2017	Novel hybrid molecule containing 2-mercaptoethylamine was synthesized starting from O-propyloxime-N-propoxy bacteriopurpurinimide (dipropoxy-BPI), which was readily oxidized in oxygen atmosphere yielding the corresponding disulfide analogue (disulfide-BPI).	Oxygen	177-183	bactericidal permeablility increasing protein	Mus musculus	141-144
29165911-5	2018	The defects and interfaces on PtPb nanoplates, controlled by the fluence of incident C+ ions, make them exhibit the volcano-like electrocatalytic activity for methanol oxidation reaction (MOR), ethanol oxidation reaction (EOR), and oxygen reduction reaction (ORR) as a function of ion irradiation fluence.	Oxygen	232-238	protein tyrosine phosphatase receptor type B	Homo sapiens	30-34
28400207-1	2018	INTRODUCTION: Growth hormone (GH) increases lean body mass, decreases fat mass, increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and improves linear growth.	Oxygen	121-127	growth hormone 1	Homo sapiens	14-28
28400207-1	2018	INTRODUCTION: Growth hormone (GH) increases lean body mass, decreases fat mass, increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and improves linear growth.	Oxygen	121-127	growth hormone 1	Homo sapiens	30-32
29202233-1	2017	Novel hybrid molecule containing 2-mercaptoethylamine was synthesized starting from O-propyloxime-N-propoxy bacteriopurpurinimide (dipropoxy-BPI), which was readily oxidized in oxygen atmosphere yielding the corresponding disulfide analogue (disulfide-BPI).	Oxygen	177-183	bactericidal permeablility increasing protein	Mus musculus	252-255
29281714-3	2017	In cancer cells exposed to oxygen or glucose deprivation, there is an increase in cellular levels of acetate, a substrate for acetate-dependent acetyl CoA synthetase 2 (Acss2) that also stimulates translocation of Acss2 from the cytosol to the nucleus.	Oxygen	27-33	acyl-CoA synthetase short-chain family member 1	Mus musculus	144-167
29339995-8	2017	Midfielders (57.2 +- 3.1 ml1 kg-1 min1) and defenders (56.1 +- 5.1 ml1 kg-1 min1) had significantly higher values of maximal oxygen uptake (VO2max) than goalkeepers (47.9 +- 0.2 ml-1 kg-1 min-1) and strikers (49.8 +- 6.2 ml-1 kg-1 min-1).	Oxygen	125-131	CD59 molecule (CD59 blood group)	Homo sapiens	34-38
29339995-8	2017	Midfielders (57.2 +- 3.1 ml1 kg-1 min1) and defenders (56.1 +- 5.1 ml1 kg-1 min1) had significantly higher values of maximal oxygen uptake (VO2max) than goalkeepers (47.9 +- 0.2 ml-1 kg-1 min-1) and strikers (49.8 +- 6.2 ml-1 kg-1 min-1).	Oxygen	125-131	CD59 molecule (CD59 blood group)	Homo sapiens	76-80
29281714-3	2017	In cancer cells exposed to oxygen or glucose deprivation, there is an increase in cellular levels of acetate, a substrate for acetate-dependent acetyl CoA synthetase 2 (Acss2) that also stimulates translocation of Acss2 from the cytosol to the nucleus.	Oxygen	27-33	acyl-CoA synthetase short-chain family member 1	Mus musculus	169-174
29281714-3	2017	In cancer cells exposed to oxygen or glucose deprivation, there is an increase in cellular levels of acetate, a substrate for acetate-dependent acetyl CoA synthetase 2 (Acss2) that also stimulates translocation of Acss2 from the cytosol to the nucleus.	Oxygen	27-33	acyl-CoA synthetase short-chain family member 1	Mus musculus	214-219
28937253-0	2017	Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.	Oxygen	104-110	sirtuin 1	Rattus norvegicus	0-5
31225445-5	2017	We demonstrated that SIRT4 reduces O2 consumption and decreases mitochondrial membrane potential in line with an increased generation of mitochondrial reactive oxygen species (mtROS).	Oxygen	35-37	sirtuin 4	Homo sapiens	21-26
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Oxygen	239-245	amyloid beta precursor protein	Homo sapiens	40-60
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Oxygen	239-245	amyloid beta precursor protein	Homo sapiens	62-67
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Oxygen	239-245	amyloid beta precursor protein	Homo sapiens	214-219
29267600-3	2017	Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-inducible factor alpha 1 (HIF-1alpha) transcription factors.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
29281819-7	2017	Upon uncoupling these pathways, we find more efficient Rlim-independent XCI in ESCs cultured under physiological oxygen conditions.	Oxygen	113-119	ring finger protein, LIM domain interacting	Mus musculus	55-59
29084846-8	2017	Of note, Thr264 is in close vicinity to a structurally and functionally important TRPV3 region comprising an atypical finger 3 and oxygen-dependent hydroxylation site.	Oxygen	131-137	transient receptor potential cation channel subfamily V member 3	Homo sapiens	82-87
29116760-0	2017	Relative Propensities of Cytochrome c Oxidase and Cobalt Corrins for Reaction with Cyanide and Oxygen: Implications for Amelioration of Cyanide Toxicity.	Oxygen	95-101	cytochrome c, somatic	Homo sapiens	25-37
29256392-3	2017	Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular lipolysis.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
29116760-9	2017	Additionally, the catalytic consumption of oxygen by the cobalt corrins is demonstrated and, in the case of cobinamide, the involvement of cytochrome c when present.	Oxygen	43-49	cytochrome c, somatic	Homo sapiens	139-151
29116760-10	2017	Particularly in the case of cobinamide, these oxygen-dependent reactions could potentially lead to erroneous assessment of the ability of the cyanide scavenger to restore the activity of cyanide-inhibited cytochrome c oxidase.	Oxygen	46-52	cytochrome c, somatic	Homo sapiens	205-217
30966002-4	2017	Compared to the previously investigated cobalt complex OMRP mediators having a fully oxygen-based first coordination sphere, this study emphasizes a few peculiarities of Co(SAL)2: a lower ability to trap radical chains as compared to Co(acac)2 and the absence of catalytic chain transfer reactions, which dominates polymerizations carried in the presence of 9-oxyphenalenone cobalt derivative.	Oxygen	85-91	spalt like transcription factor 2	Homo sapiens	173-178
29326602-6	2017	In terms of physical capacity, the IET showed that cavers had a maximum oxygen uptake (VO2max) of 2,248.7 +- 657.8 ml min-1 (i.e., 32.4 +- 6.4 ml kg-1 min-1), while anaerobic threshold (AT) occurred on average at 74.5% of VO2max.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	118-123
29276790-6	2017	Cellular adaptation to low oxygen is mediated by the transcription factors HIF-1alpha and HIF-2alpha.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
29964573-5	2017	The effluent chemical oxygen demand (COD) concentration could be lowered to 23 mg L-1.	Oxygen	22-28	L1 cell adhesion molecule	Homo sapiens	82-85
29964576-2	2017	The experimental results under different conditions showed that shortcut nitrification in the MBR was achieved by controlling the dissolved oxygen (DO) concentration to low levels (0.5-1.0 mg L-1 to 0.3-0.7 mg L-1) and changing the effective volume of the MBR to control hydraulic retention time (HRT), with the HRT in the ABR equal to 6 h, sludge reflux ratio of 100%, NOx--N reflux ratio of 300%, and temperature of 30C+-2C.	Oxygen	140-146	L1 cell adhesion molecule	Homo sapiens	192-195
29222481-1	2017	Hypoxia-inducible factor 1alpha (HIF1alpha) induces the expression of several hundred genes in hypoxia aiming at restoration of oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
29222481-1	2017	Hypoxia-inducible factor 1alpha (HIF1alpha) induces the expression of several hundred genes in hypoxia aiming at restoration of oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
29222481-2	2017	HIF prolyl-4-hydroxylases (HIF-P4Hs) regulate the stability of HIF1alpha in an oxygen-dependent manner.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-72
29371964-10	2017	We propose a novel mode of regulation of FIH1 stability by dynamic SUMOylation and deSUMOylation in the human placenta in response to changing oxygen tension, thereby mediating HIF1A transcriptional activity in physiological and pathological conditions.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-182
29209092-0	2017	Opposite effects of dissolved oxygen on the removal of As(III) and As(V) by carbonate structural Fe(II).	Oxygen	30-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	67-72
29270404-13	2017	MMP13 was upregulated with 10% PRP at both 24 and 72 h but significantly downregulated under hypoxia (1% O2) for all circumstances.	Oxygen	105-107	matrix metallopeptidase 13	Homo sapiens	0-5
28923783-9	2017	Analysis of renal collecting duct (mIMCD) and tubular epithelial (HK-2) cells stimulated with TGFbeta1 or hypoxia (1% oxygen) to activate Akt provided further evidence that BMP-7 specifically inhibited PI3K/Akt signaling.	Oxygen	118-124	thymoma viral proto-oncogene 1	Mus musculus	138-141
29131596-0	2017	Dioxygenation Reaction of a Cobalt-Nitrosyl: Putative Formation of a Cobalt-Peroxynitrite via a {CoIII(NO)(O2-)} Intermediate.	Oxygen	107-111	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	97-102
29172931-4	2017	Moreover, protein levels of VHL, HIF1A, HIF2A, EPO, and VEGF estimated by immunohistochemical staining substantiated hyperactivation of the oxygen-sensing pathway.	Oxygen	140-146	erythropoietin	Homo sapiens	47-50
29172931-4	2017	Moreover, protein levels of VHL, HIF1A, HIF2A, EPO, and VEGF estimated by immunohistochemical staining substantiated hyperactivation of the oxygen-sensing pathway.	Oxygen	140-146	vascular endothelial growth factor A	Homo sapiens	56-60
28882760-5	2017	Using an oxygen sensor, the oxygen concentration was found to increase with a rate up to 0.4muM/min, which was dependent upon the concentrations of hydrogen peroxide and the Mn-protein.	Oxygen	9-15	latexin	Homo sapiens	92-95
28882760-5	2017	Using an oxygen sensor, the oxygen concentration was found to increase with a rate up to 0.4muM/min, which was dependent upon the concentrations of hydrogen peroxide and the Mn-protein.	Oxygen	28-34	latexin	Homo sapiens	92-95
28985606-10	2017	We presented a promising method for relieving the hypoxia degree in solid tumors and down-regulating HIF-1alpha protein by directly delivering oxygen into tumors, which will be very helpful for subsequent cancer therapy.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
29472734-1	2017	The muscle-specific creatine kinase (CKM) A/G variants (rs8111989) have been associated with skeletal muscle performance in humans; they are correlated with physical performance and contribute to differences in the maximum oxygen uptake (VO2max) responses during power or endurance training.	Oxygen	223-229	creatine kinase, M-type	Homo sapiens	37-40
28887380-13	2017	One example is arachidonate 15-lipoxygenase (ALOX15), an IL4/IL13 polarization-specific protein, which was upregulated under low oxygen conditions and is associated with an increase in the rate of phagocytosis of apoptotic cells.	Oxygen	34-40	arachidonate 15-lipoxygenase	Homo sapiens	45-51
29202261-0	2017	Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.	Oxygen	65-71	MAX network transcriptional repressor	Homo sapiens	85-88
29111380-7	2017	Moreover, miR-675-5p depletion in a low-oxygen condition partially abolished the hypoxic response, including angiogenesis, and in particular restored the MSC phenotype, demonstrated by cytofluorimetric analysis.	Oxygen	40-46	microRNA 675	Homo sapiens	10-17
28643395-1	2017	Catalase is an antioxidative enzyme that converts hydrogen peroxide (H2 O2 ) produced by superoxide dismutase from highly reactive superoxide (O2- ) to water and oxygen molecules.	Oxygen	72-74	catalase	Mus musculus	0-8
28643395-1	2017	Catalase is an antioxidative enzyme that converts hydrogen peroxide (H2 O2 ) produced by superoxide dismutase from highly reactive superoxide (O2- ) to water and oxygen molecules.	Oxygen	162-168	catalase	Mus musculus	0-8
29285165-4	2017	As hypoxia-inducible factor-1alpha (HIF-1alpha) is a critical oxygen sensor and major transcriptional regulator of the hypoxic adaptive response, the current study assessed whether mitoKATP opening contributes to the chronic proliferation of human PASMCs (hPASMCs) in collaboration with HIF-1alpha and its downstream targets under hypoxic conditions.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-34
29285165-4	2017	As hypoxia-inducible factor-1alpha (HIF-1alpha) is a critical oxygen sensor and major transcriptional regulator of the hypoxic adaptive response, the current study assessed whether mitoKATP opening contributes to the chronic proliferation of human PASMCs (hPASMCs) in collaboration with HIF-1alpha and its downstream targets under hypoxic conditions.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
28444901-10	2017	Loss of EP1 results in inactivation of Hif1alpha, increased oxygen consumption rate and thus increased osteoblast differentiation.	Oxygen	60-66	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	8-11
27922759-0	2017	The Effects of Hyperbaric Oxygen Treatment on Total Antioxidant Capacity and Prolidase Activity after Bile Duct Ligation in Rats.	Oxygen	26-32	peptidase D	Rattus norvegicus	77-86
28928122-5	2017	Levels of HIFalpha are modulated by oxygen tension via the action of a family of HIF-prolyl hydroxylases (PHDs), which tag HIFalpha for proteasomal degradation.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-18
28928122-5	2017	Levels of HIFalpha are modulated by oxygen tension via the action of a family of HIF-prolyl hydroxylases (PHDs), which tag HIFalpha for proteasomal degradation.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-131
29279598-12	2017	In conclusion, high oxygen affinity haemoglobin like Hb Tak should be considered in the investigation of polycythaemic patients with abnormal Hb analyses.	Oxygen	20-26	cyclin dependent kinase 9	Homo sapiens	56-59
29230384-1	2017	Hypoxia-inducible factor 1 alpha (HIF-1alpha) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
29097020-3	2017	RESULTS: Maximal oxygen consumption (ml kg min-1) was approximately 50% higher (p &lt; 0.05) in endurance-trained runners compared with sedentary controls (65.8 +- 2.3 and 43.1 +- 3.4, respectively).	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
28165641-1	2017	Nitrate (NO3-) supplementation resulting in higher plasma nitrite (NO2-) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance-trained individuals.	Oxygen	141-147	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29135012-2	2017	In medicine, small encapsulated bubbles (&lt;10 mum) are desirable because of their utility in drug/oxygen delivery, sonoporation, and ultrasound diagnostics.	Oxygen	100-106	latexin	Homo sapiens	48-51
29230103-6	2017	Additionally, hypoxia inducible factor (HIF)-1alpha also has a stimulative elevation by O2 supplementation.	Oxygen	88-90	hypoxia inducible factor 1 alpha subunit	Gallus gallus	14-51
29230103-8	2017	Altogether, these findings demonstrated that the up-regulation of VEGFA and its receptors are accompanied by proangiogeneic factor (HIF-1alpha) expression, which were required for angiogenesis to meliorate tibia development of TBCs in hypoxia-induced bone suppression that occurred during O2 supplementation.	Oxygen	289-291	hypoxia inducible factor 1 alpha subunit	Gallus gallus	132-142
27826749-9	2017	Astrocytes isolated from TRPC3/6/7 KO mice and subjected to oxygen/glucose deprivation and subsequent reoxygenation (OGD-R, mimicking in vivo I/R injury) also exhibit enhanced Bcl-2 expression, reduced Bax expression, enhanced AKT phosphorylation, and reduced NF-kB phosphorylation.	Oxygen	60-66	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	25-30
29230384-1	2017	Hypoxia-inducible factor 1 alpha (HIF-1alpha) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
29230384-3	2017	However, in certain circumstances, HIF-1alpha regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
28925921-4	2017	Treatment with Au@Pt NPs appeared to improve oxygen in intracellular environments and decrease hypoxia-inducible factor-1alpha expression.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-126
29039921-2	2017	Each of these complexes, with CoIII/II reduction potentials that span nearly 400 mV, mediate highly selective two-electron reduction of O2 to H2O2 (93-99%) using decamethylferrocene (Fc*) as the reductant and acetic acid as the proton source.	Oxygen	136-138	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	30-35
28949512-4	2017	A 1.63 A X-ray crystallographic structure of cyanabactin in complex with PYR1 illustrates that cyanabactin"s arylnitrile mimics ABA"s cyclohexenone oxygen and engages the tryptophan lock, a key component required to stabilize activated receptors.	Oxygen	148-154	Polyketide cyclase/dehydrase and lipid transport superfamily protein	Arabidopsis thaliana	73-77
29158891-5	2017	Oxygen-dependent (through pVHL, PHDs, calcium-mediated) and independent (through growth factor signaling pathway, mdm2 pathway, HSP90) regulation of HIF-1alpha leads to angiogenesis, metastasis, and cell survival.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
29180880-8	2017	Furthermore, we found that cytochrome c oxidase subunit Vb (COX5B), the terminal enzyme of the electron transport chain, was the central gene in a coexpression network that transfers electrons from reduced cytochrome c to oxygen and, in the process, generates an electrochemical gradient across the mitochondrial inner membrane.	Oxygen	222-228	cytochrome c, somatic	Homo sapiens	27-39
29158672-0	2017	Lung transplantation and survival outcomes in patients with oxygen-dependent COPD with regard to their alpha-1 antitrypsin deficiency status.	Oxygen	60-66	serpin family A member 1	Homo sapiens	103-122
29072761-3	2017	When utilized as a 3D catalyst electrode for the OER in 1.0 M KHCO3 (pH: 8.3), as-formed CoCH/NF demands overpotential of only 332 mV to drive a geometrical catalytic current density of 10 mA cm-2, with its catalytic activity being maintained for at least 130 h. Impressively, it also demonstrates a high turnover frequency value of 0.22 mol O2 s-1 at an overpotential of 500 mV.	Oxygen	342-344	cochlin	Homo sapiens	89-93
29117182-3	2017	The Hypoxia Inducible Factor 1 (HIF-1) is a heterodimeric transcription factor used for maintenance of oxygen homeostasis and adaptation to hypoxia.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
29117182-3	2017	The Hypoxia Inducible Factor 1 (HIF-1) is a heterodimeric transcription factor used for maintenance of oxygen homeostasis and adaptation to hypoxia.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
29117182-8	2017	Although HIF-1alpha has an incomplete Oxygen-dependent Degradation Domain (ODD) relative to its human homolog, its protein level is increased under hypoxia when tested in mammalian cells.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
29124366-5	2017	The water temperatures are consistently above 25  C, which impairs dissolved oxygen levels (3.1 to 6.7 mg L-1) and may suggest eutrophication.	Oxygen	77-83	L1 cell adhesion molecule	Homo sapiens	106-109
28383996-4	2017	As a result of ETC dysfunction, NFE2L2/NRF2-silenced cancer cells exhibited the decreases in the mitochondrial membrane potential, oxygen consumption rate, and cellular adenosine triphosphate (ATP) contents.	Oxygen	131-137	NFE2 like bZIP transcription factor 2	Homo sapiens	32-38
29163184-3	2017	Here, we identified that NAC1-PDK3 axis as necessary for suppression of mitochondrial function, oxygen consumption, and more harmful ROS generation and protects cancer cells from apoptosis in hypoxia.	Oxygen	96-102	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	Mus musculus	25-29
28383996-4	2017	As a result of ETC dysfunction, NFE2L2/NRF2-silenced cancer cells exhibited the decreases in the mitochondrial membrane potential, oxygen consumption rate, and cellular adenosine triphosphate (ATP) contents.	Oxygen	131-137	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
28841267-15	2017	Oxygen uptake was not different during the control and resistor trials (3.8 +- 0.9 versus 3.7 +- 0.8 l min-1 , P &gt; 0.05), but was lower on the proportional assist ventilator trial (3.4 +- 0.7 l min-1 , P &lt; 0.05) compared with control.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
28801051-0	2017	The mechanism for oxygen reduction in cytochrome c dependent nitric oxide reductase (cNOR) as obtained from a combination of theoretical and experimental results.	Oxygen	18-24	cytochrome c, somatic	Homo sapiens	38-50
28801051-3	2017	One approach towards this goal is to compare the mechanisms for the different types of HCuOs, cytochrome c oxidase (CcO) and NOR, reducing the two substrates O2 and NO.	Oxygen	158-160	cytochrome c, somatic	Homo sapiens	94-106
28801051-4	2017	Specifically in this study, we describe the mechanism for oxygen reduction in cytochrome c dependent NOR (cNOR).	Oxygen	58-64	cytochrome c, somatic	Homo sapiens	78-90
28811274-3	2017	Exercise is accompanied by a decrease in intramuscular oxygen levels, resulting in induction of HIF-1alpha.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
29058412-1	2017	Exposure to humid O2 or ambient air affords a 5-order-of-magnitude increase in electronic conductivity of a new Prussian blue analogue incorporating CoII and VIV-oxo units.	Oxygen	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29064238-9	2017	The number of electrons transferred (n) during ORRs is 2.0 for the butano(TpYPP)CoII derivatives, consistent with only H2O2 being produced as a product for the reaction with O2.	Oxygen	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
28841267-15	2017	Oxygen uptake was not different during the control and resistor trials (3.8 +- 0.9 versus 3.7 +- 0.8 l min-1 , P &gt; 0.05), but was lower on the proportional assist ventilator trial (3.4 +- 0.7 l min-1 , P &lt; 0.05) compared with control.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	197-202
28425621-0	2017	p53-competent cells and p53-deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity.	Oxygen	80-86	tumor protein p53	Homo sapiens	0-3
28663152-3	2017	Catalase is a common enzyme ubiquitously found in all living organisms exposed to oxygen.	Oxygen	82-88	catalase	Homo sapiens	0-8
28938034-14	2017	At 13, 18, and 23 days of culture, higher ALP activity was recorded under 3% O2 pressure.	Oxygen	77-79	alkaline phosphatase, placental	Homo sapiens	42-45
28425621-0	2017	p53-competent cells and p53-deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity.	Oxygen	80-86	tumor protein p53	Homo sapiens	24-27
28425621-5	2017	Here, we show that p53 functional status correlates with oxygen functionalized graphene (f-G) cytotoxicity and genotoxicity in vitro.	Oxygen	57-63	tumor protein p53	Homo sapiens	19-22
28814529-1	2017	Hypoxia-inducible factor-1 (HIF-1) is a key gene regulator for cellular adaptation to low oxygen.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
28814529-1	2017	Hypoxia-inducible factor-1 (HIF-1) is a key gene regulator for cellular adaptation to low oxygen.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
28814529-8	2017	Interestingly, the effect of PD184161 was specific to nonhypoxic activators, since HIF-1alpha induction by hypoxia (1% O2) was unaffected under similar conditions.	Oxygen	119-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
29492090-1	2017	Background &amp; Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species.	Oxygen	125-131	catalase	Homo sapiens	28-36
28961497-0	2017	Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway.	Oxygen	51-57	NLR family, pyrin domain containing 3	Rattus norvegicus	119-124
29492090-1	2017	Background &amp; Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species.	Oxygen	125-131	catalase	Homo sapiens	38-41
28041993-6	2017	Erythropoietin (Epo) was originally discovered as a cytokine able to increase the production of red blood cells upon conditions of reduced oxygen availability.	Oxygen	139-145	erythropoietin	Homo sapiens	0-14
28803324-2	2017	NO is a gas synthesized from Larginine (a conditionally essential amino acid) and oxygen by endothelial nitric oxide synthase (eNOS).	Oxygen	82-88	nitric oxide synthase 3	Homo sapiens	92-125
28041993-6	2017	Erythropoietin (Epo) was originally discovered as a cytokine able to increase the production of red blood cells upon conditions of reduced oxygen availability.	Oxygen	139-145	erythropoietin	Homo sapiens	16-19
29157580-11	2017	For those with OSA, sleep parameters related to oxygen desaturation significantly correlated with higher fasting insulin resistance and more severe beta-cell dysfunction, as evaluated by MTT.	Oxygen	48-54	insulin	Homo sapiens	113-120
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	2-8	tumor necrosis factor	Mus musculus	55-64
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	2-8	interleukin 1 beta	Mus musculus	88-96
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	tumor necrosis factor	Mus musculus	55-64
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	interleukin 1 beta	Mus musculus	88-96
29157580-16	2017	OSA severity, especially the degree of oxygen desaturation, correlated with fasting glucose, insulin resistance, and beta-cell function.	Oxygen	39-45	insulin	Homo sapiens	93-100
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	tumor necrosis factor	Mus musculus	55-64
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	interleukin 1 beta	Mus musculus	88-96
29075011-4	2017	Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF).	Oxygen	47-49	superoxide dismutase 1, soluble	Mus musculus	130-152
29163156-1	2017	TSPO (Translocator 18 KDa; tryptophan-rich sensory protein oxygen sensor) is a constitutive outer mitochondrial membrane protein overexpressed in inflammatory cells during local or systemic processes.	Oxygen	59-65	translocator protein	Mus musculus	0-4
28263224-10	2017	CONCLUSIONS: In order for cell-based insulin replacement to be applied as a treatment for type 1 diabetes, oxygen and nutrient delivery to beta cells will need to be maintained.	Oxygen	107-113	insulin	Homo sapiens	37-44
29075011-4	2017	Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF).	Oxygen	47-49	superoxide dismutase 1, soluble	Mus musculus	154-158
28847726-2	2017	We demonstrated that curcumin (40 muM) reduced the mitochondrial coupling efficiency (percentage of oxygen consumption coupled to ATP synthesis) of intact skeletal muscle cells.	Oxygen	100-106	latexin	Homo sapiens	34-37
29187867-3	2017	It has been suggested, that lower oxygen tension, may modulate the IREB2 and FAM13A activity.	Oxygen	34-40	iron responsive element binding protein 2	Homo sapiens	67-72
28886997-2	2017	Docking results from the hCYP27B1-SDZ-88357 complex showed amino acids Arg107, Asn387 and Asp320 have an important role in binding interaction, with Asp320 part of the important acid-alcohol pair situated in the I-helix with the conserved sequence (A/G) GX (E/D) (T/S), which assumes an essential role in the binding of an oxygen molecule for catalysis.	Oxygen	323-329	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	25-33
28937222-3	2017	In this work, single-molecule fluorescence microscopy is utilized to determine the adsorption dynamics of lysozyme, a well-studied antibacterial protein, at the interface of polystyrene oxidized via UV exposure and oxygen plasma and functionalized by ligand grafting to produce varying degrees of surface hydrophilicity, surface roughness, and induced oxygen content.	Oxygen	215-221	lysozyme	Homo sapiens	106-114
28937222-3	2017	In this work, single-molecule fluorescence microscopy is utilized to determine the adsorption dynamics of lysozyme, a well-studied antibacterial protein, at the interface of polystyrene oxidized via UV exposure and oxygen plasma and functionalized by ligand grafting to produce varying degrees of surface hydrophilicity, surface roughness, and induced oxygen content.	Oxygen	352-358	lysozyme	Homo sapiens	106-114
28937222-5	2017	Adsorption dynamics of lysozyme depend on the extent and the specificity of the oxygen functionalities introduced to the polystyrene surface.	Oxygen	80-86	lysozyme	Homo sapiens	23-31
29051813-1	2017	BACKGROUND: A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1).	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	165-191
29030617-6	2017	A Monte Carlo simulation that takes various plant uptake scenarios into account yields a terrestrial gross primary productivity of 120 +- 30 PgC year-1 and soil invasion of 110 +- 30 PgC year-1, providing a quantitative assessment utilizing the oxygen isotope anomaly for quantifying CO2 cycling.	Oxygen	245-251	progastricsin	Homo sapiens	183-186
29051813-1	2017	BACKGROUND: A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1).	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	193-198
28969371-12	2017	The finding that mTORC1 activation causes an increase in oxygen consumption and renders malignant glioma cells susceptible to hypoxia and nutrient deprivation could help identify glioblastoma patient cohorts more likely to benefit from hypoxia-inducing therapies such as the VEGFA-targeting antibody bevacizumab in future clinical evaluations.	Oxygen	57-63	vascular endothelial growth factor A	Homo sapiens	275-280
28936873-8	2017	Finally, the products of Rox(III) degradation were identified as As(III) and 2-nitrohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxygen into the carbon and the other to the arsenic to catalyze cleavage of the C-As bond.	Oxygen	129-135	MAX network transcriptional repressor	Homo sapiens	25-28
28936873-8	2017	Finally, the products of Rox(III) degradation were identified as As(III) and 2-nitrohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxygen into the carbon and the other to the arsenic to catalyze cleavage of the C-As bond.	Oxygen	127-135	MAX network transcriptional repressor	Homo sapiens	25-28
27840167-4	2017	Meanwhile, catalase within those nanoparticles could trigger decomposition of endogenic TME H2O2 to generate oxygen in-situ so as to relieve tumor hypoxia.	Oxygen	109-115	catalase	Homo sapiens	11-19
28302706-10	2017	The results support the hypothesis that the microvascular acclimatization to hypoxia results from the restoration of the ROS/NO balance mediated by iNOS expression at key sites in the inflammatory cascade.NEW &amp; NOTEWORTHY The study shows that the systemic inflammation of acute hypoxia resolves via an inducible nitric oxide (NO) synthase-induced restoration of the reactive O2 species/NO balance in the systemic microcirculation.	Oxygen	379-381	nitric oxide synthase 2	Rattus norvegicus	148-152
28752896-1	2017	OBJECTIVES: Poor cell survival severely limits the beneficial effect of adipose-derived stem cell (ADSC)-based therapy for disease treatment and tissue regeneration, which might be caused by the attenuated level of hypoxia-inducible factor-1 (HIF-1) in these cells after having been cultured in 21% ambient oxygen in vitro for weeks.	Oxygen	307-313	hypoxia inducible factor 1 subunit alpha	Homo sapiens	215-241
28198604-7	2017	Pulling one tire (12.5 kg) required an oxygen uptake of 27 (4) mL kg-1 min-1 at 4 km h-1 and 0% inclination.	Oxygen	39-45	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
28675767-0	2017	Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway.	Oxygen	51-57	tumor protein p53	Homo sapiens	137-140
28198604-8	2017	Adding one more tire (6 kg) drove the oxygen uptake further up to 39 (4) mL kg-1 min-1.	Oxygen	38-44	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
27730511-4	2017	P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1beta by immune cells, which stimulates the production of oxygen reactive species.	Oxygen	142-148	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	0-13
29067455-0	2017	Hyperbaric oxygen alleviates the activation of NLRP-3-inflammasomes in traumatic brain injury.	Oxygen	11-17	NLR family pyrin domain containing 3	Homo sapiens	47-53
29067455-2	2017	In the present study, the authors investigated the effects of hyperbaric oxygen (HBO) therapy on the NLRP-3 inflammasome pathway following TBI.	Oxygen	73-79	NLR family pyrin domain containing 3	Homo sapiens	101-107
27730511-4	2017	P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1beta by immune cells, which stimulates the production of oxygen reactive species.	Oxygen	142-148	interleukin 1 beta	Mus musculus	81-89
29031730-8	2017	Furthermore, co-activation of Ppargamma2 with either Prdm16 or Zfp423 transcripts drove distinct thermogenic gene expression patterns associated with increased or decreased oxygen consumption, respectively, mimicking typical characteristics of brite/beige or white cell lineages.	Oxygen	173-179	zinc finger protein 423	Mus musculus	63-69
26845626-8	2017	Grx1-/- mice with NEC showed significantly decreased NO and increased O2 - production with increases in eNOS-SSG.	Oxygen	70-72	glutaredoxin	Mus musculus	0-4
28623709-9	2017	However, it was demonstrated that further different molecular processes connected with neurotoxicity (e.g. the inhibition of mitochondrial complex I, activation of caspase-3, apoptosis) follow later and are initiated by the reactive oxygen species.	Oxygen	233-239	caspase 3	Homo sapiens	164-173
28963486-8	2017	Low oxygen condition was also associated with reduced PlGF production in syncytializing primary cells and BeWo choriocarcinoma cells.	Oxygen	4-10	placental growth factor	Homo sapiens	54-58
28704337-9	2017	The ALR transfection prevented cells from apoptosis, which can be attributed to the preservation of the mitochondrial membrane potential, enhancement of oxygen consumption rate and production of adenosine triphosphate.	Oxygen	153-159	growth factor, augmenter of liver regeneration	Mus musculus	4-7
28961236-7	2017	Furthermore, expression of 65kDa eIF2Bepsilon led to increased survival of head and neck cancer cells under hypoxia, providing evidence that this isoform enables cells to adapt to conditions of low oxygen.	Oxygen	198-204	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	33-45
28974155-2	2017	It is well established that prostate cancer is exposed to fluctuating oxygen tensions and both acute and chronic hypoxia exist, and these conditions can upregulate angiogenesis-associated proteins such as hypoxia-inducible factor 1 alpha and vascular endothelial growth factor A.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	205-237
28974155-2	2017	It is well established that prostate cancer is exposed to fluctuating oxygen tensions and both acute and chronic hypoxia exist, and these conditions can upregulate angiogenesis-associated proteins such as hypoxia-inducible factor 1 alpha and vascular endothelial growth factor A.	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	242-278
28728105-8	2017	Molecular docking revealed that the nitrogen atom of imidazopyridines and the oxygen atom of the phenoxypropyl linker were involved in hydrogen bound interactions with Asp228 and Asp32 of BACE1 active site, respectively.	Oxygen	78-84	beta-secretase 1	Homo sapiens	188-193
29152137-1	2017	The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1alpha and constitutive HIF-1beta.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-51
28902212-4	2017	The anode was then conjugated to a compatible enzymatic cathode that employs a cascade of catalase (CAT) and bilirubin oxidase (BOD), allowing the cell to operate in an aerobic environment and/or to utilize, under anaerobic conditions for instance, hydrogen peroxide as a source for the oxygen oxidizer.	Oxygen	287-293	catalase	Homo sapiens	90-98
28902212-4	2017	The anode was then conjugated to a compatible enzymatic cathode that employs a cascade of catalase (CAT) and bilirubin oxidase (BOD), allowing the cell to operate in an aerobic environment and/or to utilize, under anaerobic conditions for instance, hydrogen peroxide as a source for the oxygen oxidizer.	Oxygen	287-293	catalase	Homo sapiens	100-103
28954928-4	2017	These cells showed increased EPO expression and secretion in response to low oxygen conditions, prolyl hydroxylase domain-containing enzyme inhibitors, and insulin-like growth factor 1.	Oxygen	77-83	erythropoietin	Homo sapiens	29-32
29152137-1	2017	The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1alpha and constitutive HIF-1beta.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
29152137-1	2017	The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1alpha and constitutive HIF-1beta.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
29082091-5	2017	Both the initial rate of pO2 change and the change in bandage pO2 at equilibration (CBP20) were found to be directly related to the metabolic oxygen consumption rate of the tissue in contact.	Oxygen	142-148	nuclear cap binding protein subunit 2	Homo sapiens	84-89
28884777-1	2017	This work demonstrates that a single Ru atom-modified covalent triazine framework (Ru-CTF) has selectivity for the electrooxidation of benzyl alcohol in water over the oxygen evolution reaction.	Oxygen	168-174	nuclear factor I C	Homo sapiens	86-89
28928465-9	2017	Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease treatment.	Oxygen	90-96	mitogen-activated protein kinase 1	Mus musculus	182-185
29158812-4	2017	Furthermore, the nanoagent-mediated hyperthermia could effectively increase the oxygen concentration in hypoxic regions thereby inhibiting the expression of hypoxia-inducible factor (HIF-1alpha).	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-193
28928465-9	2017	Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease treatment.	Oxygen	90-96	thymoma viral proto-oncogene 1	Mus musculus	186-189
28840922-0	2017	A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1alpha and HIF-2alpha.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
28970805-6	2017	Results: Peak power output (POpeak) was 359 +- 48 W. Maximal oxygen consumption ([Formula: see text]O2max) was 3.87 +- 0.46 L min-1.	Oxygen	61-67	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
29086874-0	2017	Reversible uptake of molecular oxygen by heteroligand Co(II)-L-alpha-amino acid-imidazole systems: equilibrium models at full mass balance.	Oxygen	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Oxygen	205-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Oxygen	304-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-7	2017	RESULTS: Investigations of oxygenation of the Co(II)-amino acid-imidazole systems indicated that dioxygen uptake proceeds along with a rise in pH to 9-10.	Oxygen	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
29086874-14	2017	CONCLUSIONS: The Co(II)-amac-Himid systems formed by using a [Co(imid)2]n polymer as starting material demonstrate that the reversible uptake of molecular oxygen occurs by forming dimeric mu-peroxy adducts.	Oxygen	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
28921494-1	2017	The oligoribonucleotide phosphorodithioate (PS2-RNA) modification uses two sulfur atoms to replace two non-bridging oxygen atoms at an internucleotide phosphorodiester backbone linkage.	Oxygen	116-122	taste 2 receptor member 64 pseudogene	Homo sapiens	44-47
28840922-4	2017	We studied the hypoxic activation of the transcription factors HIF-1alpha and HIF-2alpha in human endothelial cells within a spatial linear gradient of oxygen.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
28840922-5	2017	Quantification of the nuclear to cytosolic ratio of HIF immunofluorescent staining demonstrated that the threshold for HIF-1alpha activation was below 2.5% O2 while HIF-2alpha was activated throughout the entire linear gradient.	Oxygen	156-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
28840922-7	2017	These results underscore the differences between HIF-1alpha and HIF-2alpha regulation and suggest that a microfluidic oxygen gradient is a novel tool for identifying distinct hypoxic signaling activation and interactions between differentially oxygenated cells.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
28525865-3	2017	This bidentate ligand coordinates three metal ions of Co(II), Cu(II) and Fe(II) via nitrogen and oxygen atoms.	Oxygen	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28886081-8	2017	Orexin A oxygen-independently promoted the mRNA and protein expression of HIF-1alpha as well as its nuclear accumulation in HepG2 cells and the elevated HIF-1alpha protein was associated, at least partly, with the activation of the PI3K/Akt/mTOR pathway.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
28886081-8	2017	Orexin A oxygen-independently promoted the mRNA and protein expression of HIF-1alpha as well as its nuclear accumulation in HepG2 cells and the elevated HIF-1alpha protein was associated, at least partly, with the activation of the PI3K/Akt/mTOR pathway.	Oxygen	9-15	AKT serine/threonine kinase 1	Homo sapiens	237-240
28886081-8	2017	Orexin A oxygen-independently promoted the mRNA and protein expression of HIF-1alpha as well as its nuclear accumulation in HepG2 cells and the elevated HIF-1alpha protein was associated, at least partly, with the activation of the PI3K/Akt/mTOR pathway.	Oxygen	9-15	mechanistic target of rapamycin kinase	Homo sapiens	241-245
28878122-4	2017	Importantly, downregulation of Wnt11 expression was associated with cyanotic congenital heart defect (CHD) phenotypes and correlated with O2 saturation levels in hypoxemic infants with Tetralogy of Fallot (TOF).	Oxygen	138-140	Wnt family member 11	Homo sapiens	31-36
28435049-0	2017	Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity.	Oxygen	38-44	insulin like growth factor 1	Homo sapiens	134-139
28871102-5	2017	Ang II decreased oxygen consumption rate, which resulted in reactive oxygen species (ROS) generation and inhibition of ROS blocked Ang II-mediated JNK phosphorylation and TGF-beta1 induction.	Oxygen	17-23	angiotensinogen	Homo sapiens	0-6
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Oxygen	125-131	beta-secretase 1	Homo sapiens	44-49
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Oxygen	125-131	beta-secretase 1	Homo sapiens	94-99
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Oxygen	125-131	beta-secretase 1	Homo sapiens	94-99
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Oxygen	241-247	beta-secretase 1	Homo sapiens	94-99
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Oxygen	241-247	beta-secretase 1	Homo sapiens	94-99
28871102-5	2017	Ang II decreased oxygen consumption rate, which resulted in reactive oxygen species (ROS) generation and inhibition of ROS blocked Ang II-mediated JNK phosphorylation and TGF-beta1 induction.	Oxygen	17-23	angiotensinogen	Homo sapiens	131-137
28871102-5	2017	Ang II decreased oxygen consumption rate, which resulted in reactive oxygen species (ROS) generation and inhibition of ROS blocked Ang II-mediated JNK phosphorylation and TGF-beta1 induction.	Oxygen	17-23	mitogen-activated protein kinase 8	Homo sapiens	147-150
28871102-5	2017	Ang II decreased oxygen consumption rate, which resulted in reactive oxygen species (ROS) generation and inhibition of ROS blocked Ang II-mediated JNK phosphorylation and TGF-beta1 induction.	Oxygen	17-23	transforming growth factor beta 1	Homo sapiens	171-180
28658531-4	2017	METHODS: Primary HSNE cell cultures were subjected to a 1% oxygen environment for 12 hours to induce acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction.	Oxygen	59-65	CF transmembrane conductance regulator	Homo sapiens	110-161
27489224-1	2017	The mitochondrial enzyme cytochrome c oxidase catalyzes the reduction of molecular oxygen in the critical step of oxidative phosphorylation that links the oxidation of food consumed to ATP production in cells.	Oxygen	83-89	cytochrome c, somatic	Homo sapiens	25-37
27489224-3	2017	In this study, we demonstrated how oxygen binding at haem a3 could trigger long-distance conformational changes and then simulated a conformational change in an eight-residue loop near the enzyme"s substrate (cytochrome c) binding site.	Oxygen	35-41	cytochrome c, somatic	Homo sapiens	209-221
28010122-7	2017	Arteries from TgLOX mice, Ang II-infused mice, and/or SHR exhibited increased vascular H2O2 and O2.- levels, NADPH oxidase activity, and/or mitochondrial dysfunction.	Oxygen	89-91	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	26-32
28550753-4	2017	After being loaded inside liposomes, CAT within CAT@Pt (IV)-liposome shows retained and well-protected enzyme activity, and is able to trigger decomposition of H2O2 produced by tumor cells, so as to produce additional oxygen for hypoxia relief.	Oxygen	218-224	catalase	Homo sapiens	37-40
28550753-4	2017	After being loaded inside liposomes, CAT within CAT@Pt (IV)-liposome shows retained and well-protected enzyme activity, and is able to trigger decomposition of H2O2 produced by tumor cells, so as to produce additional oxygen for hypoxia relief.	Oxygen	218-224	catalase	Homo sapiens	48-51
28617934-2	2017	Firstly, the formation of the alk-1"-enyl ether bond in animal cells is oxygen dependent.	Oxygen	72-78	secretory leukocyte peptidase inhibitor	Homo sapiens	30-35
28603086-4	2017	SOD catalyzes the dismutation of the superoxide anion (O2 -) to oxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	55-57	superoxide dismutase 1	Homo sapiens	0-3
28603086-4	2017	SOD catalyzes the dismutation of the superoxide anion (O2 -) to oxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	64-70	superoxide dismutase 1	Homo sapiens	0-3
28603086-4	2017	SOD catalyzes the dismutation of the superoxide anion (O2 -) to oxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	72-74	superoxide dismutase 1	Homo sapiens	0-3
28658531-4	2017	METHODS: Primary HSNE cell cultures were subjected to a 1% oxygen environment for 12 hours to induce acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction.	Oxygen	59-65	CF transmembrane conductance regulator	Homo sapiens	163-167
28862673-7	2017	In culture under 20% oxygen, IGF-1 induced 51% hypertrophy.	Oxygen	21-27	insulin like growth factor 1	Homo sapiens	29-34
28399115-3	2017	The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function.	Oxygen	98-104	mechanistic target of rapamycin kinase	Homo sapiens	4-33
28862673-10	2017	Myoglobin mRNA expression increased by 75% under 5% O2 but decreased by 50% upon IGF-1 treatment under 20% O2, compared to control.	Oxygen	107-109	insulin like growth factor 1	Homo sapiens	81-86
28294416-6	2017	At the molecular level we observed increases in mRNA expression of MuRF-1 only at 1% O2 whereas MAFbx expression was elevated at 10%, 5%, and 1% O2 .	Oxygen	85-87	tripartite motif containing 63	Homo sapiens	67-73
28599130-4	2017	Since HSA is the most abundant serum protein in most biological organisms, its presence may affect the spectral properties of the employed probes and, consequently, the determination of the oxygen concentration.	Oxygen	190-196	albumin	Homo sapiens	6-9
28599130-8	2017	Importantly, [Ru(Phen)3]2+ retained a reliable luminescence lifetime sensitivity to the oxygen concentration in solutions supplemented with HSA and in U87 MG cancer cells.	Oxygen	88-94	albumin	Homo sapiens	140-143
28655155-6	2017	In silico analyses of the COX3 subunit postulated as the entry point for O2 into the COX protein catalytic core, points to variation in COX3 protein stability (estimated as free energy of unfolding) contributing to the variation in COX Km,app O2.	Oxygen	73-75	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	26-30
28655155-6	2017	In silico analyses of the COX3 subunit postulated as the entry point for O2 into the COX protein catalytic core, points to variation in COX3 protein stability (estimated as free energy of unfolding) contributing to the variation in COX Km,app O2.	Oxygen	73-75	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	136-140
28599130-1	2017	The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties.	Oxygen	58-64	albumin	Homo sapiens	120-139
28599130-1	2017	The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties.	Oxygen	58-64	albumin	Homo sapiens	135-138
28399115-3	2017	The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function.	Oxygen	98-104	mechanistic target of rapamycin kinase	Homo sapiens	35-39
28864287-9	2017	Kelch-like ECH-associated protein 1 (Keap1) is an oxygen sensor protein and regulates the levels of Nrf2 by the proteasomal degradation.	Oxygen	50-56	kelch like ECH associated protein 1	Homo sapiens	0-35
28349346-1	2017	Earlier the catalase-insensitive formation of organic hydroperoxides (via the interaction of organic radicals produced due to redox activity of P680+  (or TyrZ ) with molecular oxygen) has been found in Mn-depleted PS2 preparations (apo-WOC-PS2) by Khorobrykh et al.	Oxygen	177-183	taste 2 receptor member 64 pseudogene	Homo sapiens	215-218
28349346-1	2017	Earlier the catalase-insensitive formation of organic hydroperoxides (via the interaction of organic radicals produced due to redox activity of P680+  (or TyrZ ) with molecular oxygen) has been found in Mn-depleted PS2 preparations (apo-WOC-PS2) by Khorobrykh et al.	Oxygen	177-183	catalase	Homo sapiens	12-20
28864287-9	2017	Kelch-like ECH-associated protein 1 (Keap1) is an oxygen sensor protein and regulates the levels of Nrf2 by the proteasomal degradation.	Oxygen	50-56	kelch like ECH associated protein 1	Homo sapiens	37-42
28864287-9	2017	Kelch-like ECH-associated protein 1 (Keap1) is an oxygen sensor protein and regulates the levels of Nrf2 by the proteasomal degradation.	Oxygen	50-56	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
28760843-6	2017	HIF-1alpha expression in PC3 cells was significantly increased after incubating with 5% O2 for 24 h. The viability of hypoxia-induced PC3 cells was inhibited by a higher dose of irradiation than control cells.	Oxygen	88-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
28666875-2	2017	It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR as a therapeutic target in proliferative retinopathies.	Oxygen	159-165	plasminogen activator, urokinase receptor	Mus musculus	54-99
28666875-2	2017	It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR as a therapeutic target in proliferative retinopathies.	Oxygen	159-165	plasminogen activator, urokinase receptor	Mus musculus	101-105
28753307-4	2017	The benzopyrone sp2 oxygen atom was found to be position independent and a productive contributor for the ligand-enzyme complex stability.	Oxygen	20-26	Sp2 transcription factor	Homo sapiens	16-19
28621377-1	2017	Two bis-tridentate chelated cobalt(ii) complexes, which differ in the ligand structure by a methylene group, activate molecular oxygen (O2), and give different oxidation products.	Oxygen	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-37
28621377-1	2017	Two bis-tridentate chelated cobalt(ii) complexes, which differ in the ligand structure by a methylene group, activate molecular oxygen (O2), and give different oxidation products.	Oxygen	136-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-37
28852144-6	2017	ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha in mice exposed to chronic mild stress.	Oxygen	50-56	interleukin 6	Mus musculus	164-210
28753305-4	2017	In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions.	Oxygen	245-251	cytochrome c, somatic	Homo sapiens	77-89
28753305-4	2017	In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions.	Oxygen	245-251	cytochrome c, somatic	Homo sapiens	148-160
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	Oxygen	193-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28808304-7	2017	Finally, increased HIF1alpha protein expression reversed the inhibitory effect of TET1 knockdown on the migration and invasion of JEG3 cells exposed to 3% oxygen.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-28
28686251-2	2017	Sod1 dismutes superoxide anions to hydrogen peroxide and oxygen.	Oxygen	57-63	superoxide dismutase 1	Homo sapiens	0-4
28813008-6	2017	We measured the effects of a low concentration of Ang II (10-12 mol/L) on transport-related oxygen consumption (QO2), and Na/K-ATPase and Na/H-exchange (NHE) activities and expression in PTs from rats consuming tap water (Control) or 20% fructose (FRUC).	Oxygen	92-98	angiotensinogen	Rattus norvegicus	50-56
28798125-4	2017	Microbiota-induced PPAR-gamma signaling also limits the luminal bioavailability of oxygen by driving the energy metabolism of colonic epithelial cells (colonocytes) toward beta-oxidation.	Oxygen	83-89	peroxisome proliferator activated receptor gamma	Homo sapiens	19-29
28626071-5	2017	We found that NLRX1 regulates oxidative phosphorylation and cell integrity, whereas loss of NLRX1 results in increased oxygen consumption, oxidative stress, and subsequently apoptosis in epithelial cells during ischemia-reperfusion injury.	Oxygen	119-125	NLR family member X1	Homo sapiens	92-97
28801626-0	2017	HIF1alpha regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
28554130-7	2017	B10 caused a significant decrease in mitochondrial oxygen consumption rate, mitochondrial complex I, II, III, IV, and V activities, and ATP level, and increase of mitochondrial ROS production, indicating the induction of mitochondrial dysfunction.	Oxygen	51-57	granzyme C	Mus musculus	0-3
28331062-10	2017	We observed significant improvement in renal blood flow, glomerular filtration rate, and tubular Na reabsorption per mole of oxygen consumed with HIF-1alpha activation.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
28331062-11	2017	Importantly, HIF-1alpha activation significantly lowered mitochondrial oxygen consumption and superoxide production and increased mitochondrial volume density.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
28671819-4	2017	The reduced, ferrous cytoglobin can bind oxygen and will react with NO in a dioxygenation reaction to form nitrate, which dampens NO signaling.	Oxygen	41-47	cytoglobin	Homo sapiens	21-31
28723078-2	2017	The covalent Cd-O bonds affect other metal-oxygen bonds, inducing drastic changes in crystal structures and electronic states.	Oxygen	43-49	cell adhesion associated, oncogene regulated	Homo sapiens	13-17
28686842-2	2017	In the first step, the electron transfer from O2 - to SOD3 occurred without the bond formation between the donor and the acceptor and formed the triplet oxygen molecule and reduced SOD3.	Oxygen	153-159	superoxide dismutase 3	Homo sapiens	54-58
28522568-6	2017	Our findings demonstrate that PDCD4 is reduced in the mouse lung upon exposure to chronic hypoxia (10% O2 for 3 wk) and in hypoxia-exposed HPASMCs (1% O2).	Oxygen	103-105	programmed cell death 4	Mus musculus	30-35
28522568-6	2017	Our findings demonstrate that PDCD4 is reduced in the mouse lung upon exposure to chronic hypoxia (10% O2 for 3 wk) and in hypoxia-exposed HPASMCs (1% O2).	Oxygen	151-153	programmed cell death 4	Mus musculus	30-35
28522262-5	2017	We show that, in response to oxygen/glucose deprivation (OGD), acute lentiviral-mediated knockdown of TG2, as well as inhibition with an irreversible TG2 inhibitor, enhances cell survival.	Oxygen	29-35	transglutaminase 2	Homo sapiens	102-105
28447205-3	2017	Here, we investigated whether GGA protected neonatal lungs from hyperoxic stress in a murine BPD model, and measured the serum HSP70 levels in preterm humans treated with oxygen.	Oxygen	171-177	heat shock protein 1B	Mus musculus	127-132
28461244-5	2017	Through inhibition of LDHA, miR-30a-5p dampens glycolysis by decreasing glucose uptake, lactate production, ATP generation, and extracellular acidification rate (ECAR), and increasing oxygen consumption rate (OCR) in breast cancer cells.	Oxygen	184-190	lactate dehydrogenase A	Homo sapiens	22-26
29048538-5	2017	We also discovered that TET expression was enhanced under low oxygen (5%) culture conditions, which facilitated CNS2 DNA demethylation and stabilization of Foxp3 expression in a TET2- and TET3-dependent manner.	Oxygen	62-68	tet methylcytosine dioxygenase 3	Homo sapiens	188-192
29082365-13	2017	CONCLUSION: Continuous exposure of 2 MAC sevoflurane in 2 lit/min O2 simultaneous during prepubertal may create more testicular tissue damage in terms of cellular and molecular function compared to continuous exposure to lower level of sevoflurane by increase in ratio of Bax/Bcl2 and apoptosis in germ cells after puberty.	Oxygen	66-68	B cell leukemia/lymphoma 2	Mus musculus	276-280
28572492-12	2017	In summary, not only does selective beta1 blockade reduce myocardial oxygen demand during exercise, but it also unveils beta2-receptor-mediated coronary exercise hyperemia.NEW &amp; NOTEWORTHY In this study, we evaluated the role of vascular beta1 vs. beta2 receptors in coronary exercise hyperemia in a single-blind, randomized, crossover study in healthy men.	Oxygen	69-75	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	36-41
28452899-8	2017	Mechanistic analysis revealed oxygen consumption increased in response to Cyt c at 22 C, whereas neither Cyt c or Res affected oxygen consumption at 4 C. Lipid peroxidation was only reduced at 22 C (day 7 and day 10), but remained unchanged at 4 C, or when Res or Cyt c was added.	Oxygen	30-36	cytochrome c, somatic	Homo sapiens	74-79
28527012-5	2017	Oxygen uptake ([Formula: see text]) was lower in the hypocapnia than control trials (822 +- 235 vs. 1645 +- 245 mL min-1; mean +- SD) during Ex1, but not Ex2 or Ex3, without a between-trial difference in the power output during the exercises.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
28656256-4	2017	HS-1793 was found to inhibit hypoxia (1.0% oxygen)-induced HIF-1alpha expression at the protein level, and its inhibitory effect was more potent than that of resveratrol in MCF-7 and MDA-MB-231 breast cancer cells.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
28378105-6	2017	In the media of brain microvascular endothelial cells (BMECs), oxygen and glucose deprivation-reperfusion (OGD-R) could remarkably lead to the elevation of TNF-alpha and IL-1beta levels, while magnolol evidently reversed these effects.	Oxygen	63-69	tumor necrosis factor	Mus musculus	156-165
28378105-6	2017	In the media of brain microvascular endothelial cells (BMECs), oxygen and glucose deprivation-reperfusion (OGD-R) could remarkably lead to the elevation of TNF-alpha and IL-1beta levels, while magnolol evidently reversed these effects.	Oxygen	63-69	interleukin 1 beta	Mus musculus	170-178
28716941-0	2017	Cryptic oxygen cycling in anoxic marine zones.	Oxygen	8-14	cripto, FRL-1, cryptic family 1	Homo sapiens	0-7
28627618-2	2017	It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)-1alpha, in order to adapt and survive.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-186
28627618-3	2017	HIF-1alpha is important in the regulation of oxygen homeostasis and the transcription of hundreds of genes in response to conditions of hypoxia, hence maintaining energy and redox homeostasis.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
28521045-13	2017	The partial pressure of water and oxygen were found to depend on the pump down parameters due to the formation of fog in the chamber and desorption of water from the birds and the walls of the vacuum chamber.	Oxygen	34-40	zinc finger protein, FOG family member 1	Homo sapiens	114-117
28624952-2	2017	By the production of renin, erythropoietin and arachidonate metabolites (medullipin) subsets of renal interstitial fibroblasts and pericytes in different kidney zones play a central role in salt, blood pressure and oxygen homeostasis of the body.	Oxygen	215-221	erythropoietin	Homo sapiens	28-42
28798696-2	2017	Three mitophagy receptors, FUNDC1, BNIP3 and NIX, induce the removal of dysfunctional mitochondria (mitophagy) under prolonged hypoxic conditions in mammalian cells, to maintain oxygen homeostasis and prevent cell death.	Oxygen	178-184	BCL2 interacting protein 3	Homo sapiens	35-40
28531964-2	2017	Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1alpha-subunit (HIF-alpha).	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-101
28374809-9	2017	Men had significantly higher resting oxygen uptake compared to women, 0.19 vs 0.15 l min-1 (P=0.005), REE per 24 h, 1286 vs 1030 kcal (P=0.003) and EE during weight-bearing activities.	Oxygen	37-43	CD59 molecule (CD59 blood group)	Homo sapiens	85-90
28374809-10	2017	However, these became nonsignificant after adjustment for body weight and speed of movement, with a mean resting oxygen uptake of 2.47 ml O2 per kg min-1 for the whole group (women 2.43 and men 2.57 ml O2 kg-1 min-1, P=0.49).	Oxygen	113-119	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
28374809-13	2017	The mean resting oxygen uptake for the whole group was 2.47 ml O2 kg-1 min-1.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
28750088-0	2017	A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.	Oxygen	57-63	aldehyde oxidase 1	Homo sapiens	92-108
28798696-9	2017	Molecular evolutionary analysis revealed that BNIP3 and NIX, as the targets of oxygen sensing HIF-1alpha, showed higher rates of substitution in fishes than in mammals.	Oxygen	79-85	BCL2 interacting protein 3	Homo sapiens	46-51
28702583-6	2017	Single crystal X-ray diffraction was used to determine the structure of a dimeric complex, [(Dipp2NDI)Mg2(THF)3]2, that features strong coordination of Mg2+ by the oxygen atoms of the reduced NDI.	Oxygen	164-170	arginine vasopressin receptor 2	Homo sapiens	98-101
28733640-3	2017	We further show that TGF-beta and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy.	Oxygen	144-150	activin A receptor, type II-like 1	Mus musculus	34-38
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	Oxygen	100-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
28746471-7	2017	Under alkaline pH and HIF1alpha regulation, glucose consumption, extracellular lactate production, and LDH activity of BCSCs were upregulated while O2 consumption was downregulated.	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-31
28728562-9	2017	Immunofluorescence showed that the intensity of staining for HIF-2alpha, MnSOD and LIFR were higher in 3% O2.	Oxygen	106-108	superoxide dismutase 2, mitochondrial	Mus musculus	73-78
28728562-8	2017	The transcription levels of MnSOD, PRDX5, VEGF and GLUT-3 also significantly increased in 3% O2 compared with 20% O2 (P &lt; 0.05).	Oxygen	93-95	superoxide dismutase 2, mitochondrial	Mus musculus	28-33
28728562-8	2017	The transcription levels of MnSOD, PRDX5, VEGF and GLUT-3 also significantly increased in 3% O2 compared with 20% O2 (P &lt; 0.05).	Oxygen	114-116	superoxide dismutase 2, mitochondrial	Mus musculus	28-33
28723567-3	2017	Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption, obesity, decreased core body temperature, and cold sensitivity.	Oxygen	148-154	sirtuin 6	Mus musculus	12-17
29137270-9	2017	Human MSC transplantation in LPS- and O2-treated rats reduced the MWT, RV:LV thickness ratio, and beta-MHC and TLR4 expression to normal levels.	Oxygen	38-40	toll-like receptor 4	Rattus norvegicus	111-115
28657302-0	2017	PtPb/PtNi Intermetallic Core/Atomic Layer Shell Octahedra for Efficient Oxygen Reduction Electrocatalysis.	Oxygen	72-78	protein tyrosine phosphatase receptor type B	Homo sapiens	0-4
28723567-3	2017	Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption, obesity, decreased core body temperature, and cold sensitivity.	Oxygen	156-158	sirtuin 6	Mus musculus	12-17
28947973-0	2017	Hyperbaric oxygen protects type II collagen in interleukin-1beta-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway.	Oxygen	11-17	interleukin 1 beta	Rattus norvegicus	47-64
28947973-1	2017	The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1beta (IL-1beta) induced rat"s mandibular condylar chondrocytes.	Oxygen	66-72	interleukin 1 beta	Rattus norvegicus	93-110
28947973-1	2017	The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1beta (IL-1beta) induced rat"s mandibular condylar chondrocytes.	Oxygen	66-72	interleukin 1 beta	Rattus norvegicus	112-120
28947973-2	2017	Chondrocytes were exposure to Hyperbaric oxygen after induced inflammatory by IL-1beta.	Oxygen	41-47	interleukin 1 beta	Rattus norvegicus	78-86
28947973-6	2017	However, Hyperbaric oxygen can inhibits IL-1beta induced inflammatory response in chondrocytes though block the JNK/c-Jun signaling pathway and up-regulate the expression of Sox-9 and COL2.	Oxygen	20-26	interleukin 1 beta	Rattus norvegicus	40-48
28579483-0	2017	S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures.	Oxygen	69-75	glutamic acid decarboxylase 2	Mus musculus	19-24
28315322-1	2017	Investigation into the regulation of the erythropoietin gene by oxygen led to the discovery of a process of direct oxygen sensing that transduces many cellular and systemic responses to hypoxia.	Oxygen	64-70	erythropoietin	Homo sapiens	41-55
28315322-1	2017	Investigation into the regulation of the erythropoietin gene by oxygen led to the discovery of a process of direct oxygen sensing that transduces many cellular and systemic responses to hypoxia.	Oxygen	115-121	erythropoietin	Homo sapiens	41-55
28336293-1	2017	Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
28336293-1	2017	Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
28336293-3	2017	This review provides a compendium of proteins that interact with the HIF-1alpha subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.	Oxygen	140-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
28336293-3	2017	This review provides a compendium of proteins that interact with the HIF-1alpha subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.	Oxygen	140-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
28336293-3	2017	This review provides a compendium of proteins that interact with the HIF-1alpha subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.	Oxygen	156-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
28336293-3	2017	This review provides a compendium of proteins that interact with the HIF-1alpha subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.	Oxygen	156-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
28704555-5	2017	A two-compartment description was adopted to model plasma IL-6 changes in response to oxygen uptake"s variation during an exercise bout.	Oxygen	86-92	interleukin 6	Homo sapiens	58-62
28512254-4	2017	Epac1-deficient mice showed a reduced amount of pre-retinal neovascularizations in the model of oxygen-induced retinopathy, which is predominantly driven by vascular endothelial growth factor (VEGF).	Oxygen	96-102	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	0-5
28471085-2	2017	Surprisingly, highly charged protein ions (HCPI) can readily protonate non-polar molecules and inert gases, including Ar, O2 , and N2 in thermal IMRs.	Oxygen	122-124	ubiquitin specific peptidase like 1	Homo sapiens	14-36
28684847-7	2017	Under salt stress, the activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) enzymes in transgenic chrysanthemum were significantly higher than those in WT, whereas the accumulation of H2O2, O2- and malondialdehyde (MDA) was reduced in transgenic chrysanthemum.	Oxygen	211-213	catalase	Homo sapiens	96-99
28362162-4	2017	To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61.	Oxygen	108-114	vascular endothelial growth factor A	Homo sapiens	149-153
28586102-5	2017	The resulting RET-BDP shows significantly enhanced absorption and singlet oxygen efficiency relative to that of the acceptor moiety of the photosensitizer alone in the NIR range.	Oxygen	74-80	AT-rich interaction domain 3B	Homo sapiens	18-21
27568384-3	2017	Hypoxia is characterized in molecular terms by the stabilization of hypoxia-inducible factor (HIF) 1alpha, a subunit of the heterodimeric nuclear transcriptional factor HIF-1 and a master regulator of oxygen homeostasis.	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-105
28668074-14	2017	CONCLUSION: The results confirm the hypothesis that Growth Restricted foetuses (FGR) have fewer oxygen reserves to deal with labour.	Oxygen	96-102	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
28526370-4	2017	Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1alpha protein.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
28672923-4	2017	The aim of the present study was to evaluate the effects of terlipressin, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).	Oxygen	129-135	arginine vasopressin	Rattus norvegicus	93-104
28637827-6	2017	Therefore, oxygen, nutrient, and hormonal passage over the encapsulation membrane is solely dependent on diffusion over the immune barrier, contributing to delays in glucose sensing and insulin secretion kinetics.	Oxygen	11-17	insulin	Homo sapiens	186-193
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	Oxygen	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
28693255-4	2017	Lack of oxygen activates hypoxia-inducible factor (HIF) protein, which is followed by the upregulation of growth factors, including vascular endothelial growth factor and activation of the RTK signaling pathway.	Oxygen	8-14	vascular endothelial growth factor A	Homo sapiens	132-166
28433661-1	2017	SOD2 is the primary antioxidant enzyme neutralizing  O2- in mitochondria.	Oxygen	53-55	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
28096297-9	2017	We conclude that differential regulation of exocytosis by TNF-alpha involves the actin cytoskeleton and is a necessary component for priming of the 2 major neutrophil antimicrobial defense mechanisms: oxygen radical generation and release of toxic granule contents.	Oxygen	201-207	tumor necrosis factor	Homo sapiens	58-67
27572850-3	2017	The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth in response to nutrient, hormone, and oxygen levels.	Oxygen	118-124	mechanistic target of rapamycin kinase	Homo sapiens	4-33
27572850-3	2017	The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth in response to nutrient, hormone, and oxygen levels.	Oxygen	118-124	mechanistic target of rapamycin kinase	Homo sapiens	35-39
27987212-1	2017	The plant mitochondrial electron transport chain (ETC) is bifurcated such that electrons from ubiquinol are passed to oxygen via the usual cytochrome path or through alternative oxidase (AOX).	Oxygen	118-124	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	166-185
27987212-1	2017	The plant mitochondrial electron transport chain (ETC) is bifurcated such that electrons from ubiquinol are passed to oxygen via the usual cytochrome path or through alternative oxidase (AOX).	Oxygen	118-124	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	187-190
27995331-5	2017	Quantitative RT-PCR analyses showed that oxygen deficiency had different effects on the expression of the hypoxia-induced genes Rboh B, D, G, and I in the AtERF73/HRE1 knockout lines.	Oxygen	41-47	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	155-162
28627561-5	2017	Due to "CO-Promoted O2 Activation", the termolecular Eley-Rideal (TER) mechanism is the most relevant one for CO oxidation over Ag1/BN and the rate-limiting reaction barrier is only 0.33 eV.	Oxygen	20-22	thioredoxin domain containing 12	Homo sapiens	128-134
28838128-9	2017	Several plasma membrane and tonoplast ion channels (such as TPC, AKT and KCO) and oxygen domain-containing proteins with predicted oxygen-sensing ability were identified and discussed.	Oxygen	131-137	AKT serine/threonine kinase 1	Homo sapiens	65-68
28571041-6	2017	We also compared CBF1 expression in cells exposed to low and high oxygen tension.	Oxygen	66-72	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	17-21
27397579-8	2017	Limited oxygen availability not only attenuates NOS2 activity but also causes accumulation of hypoxia-inducible factors 1 and 2 (HIF-1/HIF-2).	Oxygen	8-14	nitric oxide synthase 2	Homo sapiens	48-52
28449325-0	2017	Electrosynthesis of Bifunctional WS3-x /Reduced Graphene Oxide Hybrid for Hydrogen Evolution Reaction and Oxygen Reduction Reaction Electrocatalysis.	Oxygen	106-112	dynactin subunit 6	Homo sapiens	33-36
28449325-6	2017	The excellent bifunctional electrocatalytic performances of WS3-x /rGO towards both HER and oxygen reduction reaction stemmed from the coupled impacts of amplified electrical conductivity and surface area of rGO; the presence of metallic species within rGO, resulting from the oxidation process; and the amount of WS3-x successfully electrodeposited in the hybrid.	Oxygen	92-98	dynactin subunit 6	Homo sapiens	60-63
28635661-4	2017	Under hypoxia (2% O2), the expression of GRP78 was significantly increased via hypoxia-inducible factor (HIF)-1alpha.	Oxygen	18-20	heat shock protein 5	Mus musculus	41-46
28537706-6	2017	X-ray photoelectron spectra and soft X-ray absorption spectra show that the surface lattice oxygen of Na1/HMO has a higher electronic density than that of Ag1/HMO, which is responsible for its higher catalytic efficiency in the oxidation of HCHO.	Oxygen	92-98	thioredoxin domain containing 12	Homo sapiens	155-162
28730075-0	2017	CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	85-91	chemokine (C-C motif) receptor 7	Mus musculus	0-4
28630416-2	2017	Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the involvement of HIF-1 activity in lidocaine-induced cell death.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-34
28630416-2	2017	Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the involvement of HIF-1 activity in lidocaine-induced cell death.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
28630416-4	2017	We demonstrate that HIF-1 suppressed oxygen consumption and facilitated glycolysis in a pyruvate dehydrogenase kinase-1-dependent manner and that activation of HIF-1 conferred resistance to lidocaine-induced cell death.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
28730075-1	2017	AIM: To investigate the role of CCR7/p-ERK1/2/VEGF signaling in the mouse model of oxygen-induced retinopathy (OIR).	Oxygen	83-89	chemokine (C-C motif) receptor 7	Mus musculus	32-36
28730075-9	2017	RESULTS: High oxygen promoted retinal neovascularization (P&lt;0.05) and increased the number of endothelial nuclei in new vessels extending from the retina to the vitreous body; CCR7 promoted this process (P&lt;0.05).	Oxygen	14-20	chemokine (C-C motif) receptor 7	Mus musculus	179-183
28584285-3	2017	A helium/oxygen radio frequency driven atmospheric plasma profoundly induced apoptosis in THP-1 cells whereas helium, humidified helium, and humidified helium/oxygen plasmas were inefficient.	Oxygen	9-15	GLI family zinc finger 2	Homo sapiens	90-95
27829557-2	2017	Oxygen-plasma-treated rGO surfaces were employed as reactive interfaces for the detection of amyloid-beta (Abeta) peptides, the pathological hallmarks of Alzheimer"s disease (AD), as the target analytes.	Oxygen	0-6	amyloid beta precursor protein	Homo sapiens	93-105
27829557-2	2017	Oxygen-plasma-treated rGO surfaces were employed as reactive interfaces for the detection of amyloid-beta (Abeta) peptides, the pathological hallmarks of Alzheimer"s disease (AD), as the target analytes.	Oxygen	0-6	amyloid beta precursor protein	Homo sapiens	107-112
27829557-6	2017	Finally, the feasibility of the oxygen-plasma-treated rGO sensors as a diagnostic tool was evaluated with clinical samples of neural-derived exosomal Abeta peptides extracted from apparent AD patients and normal controls (NC).	Oxygen	32-38	amyloid beta precursor protein	Homo sapiens	150-155
28619042-8	2017	RESULTS: Targeting HIF-1alpha reduced lactate content, and increased both oxygen consumption and hypoxic fraction in these tumors after exposure to short-term continuous hypoxia.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
28450115-12	2017	We revealed that an insufficient level of oxygen in the cysts is the main factor for the unusual stabilization of IRP2 against iron-mediated degradation, which provides aberrant uptake of iron in ovarian endometrial stromal cells and can potentially lead to carcinogenesis.	Oxygen	42-48	iron responsive element binding protein 2	Homo sapiens	114-118
28670397-5	2017	In this in vitro experiment, we obtained RAW264.7 macrophages and human peripheral blood mononuclear cells (PBMCs) incubated by LPS or plasma from septic patients to explore the NF-kappaB pathway in the effect of the inhalation of sevoflurane combined with oxygen in sepsis.	Oxygen	257-263	nuclear factor kappa B subunit 1	Homo sapiens	178-187
28670397-7	2017	We also founded that 0.5 MAC of sevoflurane in 60% oxygen inhibited the nuclear translocation of NF-kappaB in human PBMCs induced by LPS or plasma from septic patients.	Oxygen	51-57	nuclear factor kappa B subunit 1	Homo sapiens	97-106
28534396-3	2017	It is first proposed that the active sites, wherein O2 molecules become adsorbed and activated, be tailored by synergistic graphitic and pyridinic N atoms (GrN and PyN, respectively), which remarkably accelerate the generation of highly chemically reactive O-containing species.	Oxygen	52-54	granulin precursor	Homo sapiens	156-159
28534396-5	2017	These active sites steer the electron transfer between O2 molecules, and the reaction centers in a one-way transmission manner along the PyN   O1   O2   C   GrN path.	Oxygen	55-57	granulin precursor	Homo sapiens	157-160
28615726-8	2017	The above characterisations showed that alterations in glucose concentration and/or oxygen level as induced by chemical hypoxia causes elevations in VEGF produced in ARPE-19 which in turn affected directional growth of HUVEC.	Oxygen	84-90	vascular endothelial growth factor A	Homo sapiens	149-153
28591612-7	2017	O2 shielding provided stronger apoptotic effects trough caspase-3 activation compared to N2 shielding.	Oxygen	0-2	caspase 3	Homo sapiens	56-65
28509540-0	2017	Characterization of the High-Spin Co(II) Intermediate Species of the O2-Evolving Co4O4 Cubic Molecules.	Oxygen	69-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
28509540-8	2017	Additionally, a possible role of the symmetry of the Co(II) species and a proposed model that explains its formation during the O2-evolving process of the Co4O4 cubic molecules are discussed.	Oxygen	128-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28584285-0	2017	Oxygen atoms are critical in rendering THP-1 leukaemia cells susceptible to cold physical plasma-induced apoptosis.	Oxygen	0-6	GLI family zinc finger 2	Homo sapiens	39-44
28168378-1	2017	A novel micro-pressure swirl reactor (MPSR) was designed and applied to treat domestic wastewater at low temperature by acclimating microbial biomass with steadily decreasing temperature from 15 to 3  C. Chemical oxygen demand (COD) was constantly removed by 85% and maintained below 50 mg L-1 in the effluent during the process.	Oxygen	213-219	immunoglobulin kappa variable 1-16	Homo sapiens	290-293
28416613-2	2017	As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-195
28416613-2	2017	As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	197-207
28416613-2	2017	As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-195
28416613-2	2017	As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	197-207
28416613-3	2017	We show here that HIF-1alpha links pathways for oxygen sensing and feedback control of cholesterol synthesis in human fibroblasts by directly activating transcription of the INSIG-2 gene.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
28416613-3	2017	We show here that HIF-1alpha links pathways for oxygen sensing and feedback control of cholesterol synthesis in human fibroblasts by directly activating transcription of the INSIG-2 gene.	Oxygen	48-54	insulin induced gene 2	Homo sapiens	174-181
28416613-8	2017	These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.	Oxygen	151-157	insulin induced gene 2	Homo sapiens	54-61
28537399-1	2017	Palladium-catalyzed arene C(sp2)-H acetoxylation has emerged as a powerful tool to construct a carbon-oxygen (C-O) bond.	Oxygen	102-108	Sp2 transcription factor	Homo sapiens	26-31
26990284-5	2017	In response to several stimuli, p66Shc migrates into mitochondria where it catalyses electron transfer from cytochrome c to oxygen resulting in hydrogen peroxide formation.	Oxygen	124-130	cytochrome c, somatic	Homo sapiens	108-120
28267240-4	2017	MT1-MMP also has a non-protease activity in that it inhibits the oxygen-dependent suppression of hypoxia-inducible factors (HIFs) via Munc18-1-interacting protein 3 (Mint3) and thereby enhances the expression of HIF target genes.	Oxygen	65-71	amyloid beta (A4) precursor protein-binding, family A, member 3	Mus musculus	134-164
28267240-4	2017	MT1-MMP also has a non-protease activity in that it inhibits the oxygen-dependent suppression of hypoxia-inducible factors (HIFs) via Munc18-1-interacting protein 3 (Mint3) and thereby enhances the expression of HIF target genes.	Oxygen	65-71	amyloid beta (A4) precursor protein-binding, family A, member 3	Mus musculus	166-171
28223135-0	2017	Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-56
28589682-7	2017	Long-term ASC expansion at low O2 (5%) revoked in part the replicative senescence-associated alterations.	Oxygen	31-33	PYD and CARD domain containing	Homo sapiens	10-13
28270521-9	2017	Further, retinal miR-21 levels were increased, while PPARalpha levels were decreased in oxygen-induced retinopathy (OIR).	Oxygen	88-94	peroxisome proliferator activated receptor alpha	Mus musculus	53-62
27600268-9	2017	Thus, we discovered a novel biological pathway of soluble biglycan inducing HIF-2alpha protein stabilization and Epo production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.	Oxygen	145-151	biglycan	Mus musculus	58-66
28326455-11	2017	Levels of O2.- and NO also showed a significant fall in case of the group treated with MMP-2 inhibitor and TNFR1 antibody both.	Oxygen	10-12	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	107-112
28583723-2	2017	mTOR forms two compositionally and functionally distinct complexes, mTORC1 and mTORC2, which are crucial for coordinating nutrient, energy, oxygen, and growth factor availability with cellular growth, proliferation, and survival.	Oxygen	140-146	mechanistic target of rapamycin kinase	Homo sapiens	0-4
28223135-5	2017	Hypoxia inducible factor-1 (HIF-1) plays a key transcriptional role in the adaptation of cell physiology in relation with the oxygen content within a cell.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
28223135-5	2017	Hypoxia inducible factor-1 (HIF-1) plays a key transcriptional role in the adaptation of cell physiology in relation with the oxygen content within a cell.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Oxygen	111-113	triosephosphate isomerase 1	Homo sapiens	51-76
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Oxygen	111-113	triosephosphate isomerase 1	Homo sapiens	78-81
28422389-3	2017	Both of desferrioxamine and catechin could inhibit TIM nitration induced by heme-H2 O2 -NaNO2 and SIN-1 and protein oxidation induced by SIN-1, but promoted heme-H2 O2 -NaNO2 -induced protein oxidation.	Oxygen	84-86	triosephosphate isomerase 1	Homo sapiens	51-54
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Oxygen	111-113	MAPK associated protein 1	Homo sapiens	260-265
27829319-5	2017	OBJECTIVE: Evaluation of Sig1R, SOD1, and SOD2 expression in different concentrations of oxygen (1%, 10%, 21%) in colon adenocarcinoma cell lines.	Oxygen	89-95	superoxide dismutase 1	Homo sapiens	32-36
28282582-1	2017	Catalase, a heme enzyme, which catalyzes decomposition of hydrogen peroxide to water and molecular oxygen, is one of the main enzymes of the antioxidant defense system of the cell.	Oxygen	99-105	catalase	Homo sapiens	0-8
27573480-5	2017	Reduced mRNA levels of transforming growth factor-beta1 and alkaline phosphatase in HBO-treated rats on day 28 suggested that a quicker resolution in both soft tissue and bone remodeling occurred following oxygen treatment.	Oxygen	206-212	transforming growth factor, beta 1	Rattus norvegicus	23-55
27829319-10	2017	RESULTS: We observed significant changes in expression of Sig1R, SOD1, SOD2 due to different oxygen concentrations.	Oxygen	93-99	superoxide dismutase 1	Homo sapiens	65-69
28088487-1	2017	Retinopathy of prematurity (ROP) is a major cause of childhood blindness in the world and is caused by oxygen-induced damage to the developing retinal vasculature, resulting in hyperoxia-induced vaso-obliteration and subsequent delayed retinal vascularization and hypoxia-induced pathological neovascularization driven by vascular endothelial growth factor (VEGF) signaling pathway in retina.	Oxygen	103-109	vascular endothelial growth factor A	Homo sapiens	322-356
28088487-1	2017	Retinopathy of prematurity (ROP) is a major cause of childhood blindness in the world and is caused by oxygen-induced damage to the developing retinal vasculature, resulting in hyperoxia-induced vaso-obliteration and subsequent delayed retinal vascularization and hypoxia-induced pathological neovascularization driven by vascular endothelial growth factor (VEGF) signaling pathway in retina.	Oxygen	103-109	vascular endothelial growth factor A	Homo sapiens	358-362
28276602-5	2017	DOE results revealed that MSC spheroids formed with 40,000 cells per spheroid in 1% oxygen with an inflammatory stimulus (Spheroid 1) would exhibit enhanced PGE2 and VEGF production versus those formed with 10,000 cells per spheroid in 21% oxygen with no inflammatory stimulus (Spheroid 2).	Oxygen	84-90	vascular endothelial growth factor A	Homo sapiens	166-170
28337518-5	2017	Under oxygen deficiency, enhancements of the transcripts of alcohol dehydrogenase 1 (ADH1) and pyruvate decarboxylase 1 (PDC1) and the activities of ADH, PDC and lactate dehydrogenase in WT are clearly reduced in the single mutants, and more strongly reduced in the double mutant.	Oxygen	6-12	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	95-119
28337518-5	2017	Under oxygen deficiency, enhancements of the transcripts of alcohol dehydrogenase 1 (ADH1) and pyruvate decarboxylase 1 (PDC1) and the activities of ADH, PDC and lactate dehydrogenase in WT are clearly reduced in the single mutants, and more strongly reduced in the double mutant.	Oxygen	6-12	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	121-125
28495827-0	2017	Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats.	Oxygen	11-17	sirtuin 1	Rattus norvegicus	92-97
31457587-4	2017	The resulting catalase MIC preserved the catalase activity, confirmed by monitoring the O2 concentration with a Clark-type oxygen electrode, in spite of MIC formation.	Oxygen	88-90	catalase	Homo sapiens	14-22
28615919-2	2017	The phylogenetic studies of hypoxia-inducible factor-1alpha (HIF-1alpha) sequences across different organisms/species may leave a clue on the evolutionary relationships and its probable correlation to tumorigenesis and adaptation to low oxygen environments.	Oxygen	237-243	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-59
28615919-2	2017	The phylogenetic studies of hypoxia-inducible factor-1alpha (HIF-1alpha) sequences across different organisms/species may leave a clue on the evolutionary relationships and its probable correlation to tumorigenesis and adaptation to low oxygen environments.	Oxygen	237-243	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
28318896-3	2017	Oxygen levels, as well as other factors, control the activity of HIF-1alpha.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
28486846-10	2017	The optimum conditions for the maximum chemical oxygen demand sonocatalytic degradation of 85.82% were found to be pH 6.9, cupric oxide nanoparticles dosage of 0.05 gr L-1, and the ultrasonic frequency of 130 kHz at a contact time of 10 min.	Oxygen	48-54	immunoglobulin kappa variable 1-16	Homo sapiens	168-171
28690378-7	2017	In Lig No#5, we decreased the hydrophobicity by adding oxygen in the hydrophobic tail of the molecule at positions C5 and C10.	Oxygen	55-61	homeobox C10	Homo sapiens	122-125
31457587-4	2017	The resulting catalase MIC preserved the catalase activity, confirmed by monitoring the O2 concentration with a Clark-type oxygen electrode, in spite of MIC formation.	Oxygen	88-90	catalase	Homo sapiens	41-49
31457587-4	2017	The resulting catalase MIC preserved the catalase activity, confirmed by monitoring the O2 concentration with a Clark-type oxygen electrode, in spite of MIC formation.	Oxygen	123-129	catalase	Homo sapiens	14-22
31457587-4	2017	The resulting catalase MIC preserved the catalase activity, confirmed by monitoring the O2 concentration with a Clark-type oxygen electrode, in spite of MIC formation.	Oxygen	123-129	catalase	Homo sapiens	41-49
28593139-4	2017	It was observed that the NO dioxygenase activity of Cygb only slightly changed (~ 25%) while the P50 of O2 binding to Cygb changed over four-fold with these modifications.	Oxygen	104-106	cytoglobin	Homo sapiens	118-122
28558702-1	2017	BACKGROUND: Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia.	Oxygen	138-144	arginine vasopressin	Homo sapiens	39-50
28593139-0	2017	Oxygen binding and nitric oxide dioxygenase activity of cytoglobin are altered to different extents by cysteine modification.	Oxygen	0-6	cytoglobin	Homo sapiens	56-66
28593139-1	2017	Cytoglobin (Cygb), like other members of the globin family, is a nitric oxide (NO) dioxygenase, metabolizing NO in an oxygen (O2)-dependent manner.	Oxygen	85-91	cytoglobin	Homo sapiens	0-10
28593139-1	2017	Cytoglobin (Cygb), like other members of the globin family, is a nitric oxide (NO) dioxygenase, metabolizing NO in an oxygen (O2)-dependent manner.	Oxygen	85-91	cytoglobin	Homo sapiens	12-16
28593139-5	2017	Our results suggest that it is possible to separately regulate one Cygb function (such as O2 binding) without largely affecting the other Cygb functions (such as its NO dioxygenase activity).	Oxygen	90-92	cytoglobin	Homo sapiens	67-71
28593139-1	2017	Cytoglobin (Cygb), like other members of the globin family, is a nitric oxide (NO) dioxygenase, metabolizing NO in an oxygen (O2)-dependent manner.	Oxygen	126-128	cytoglobin	Homo sapiens	0-10
28593139-1	2017	Cytoglobin (Cygb), like other members of the globin family, is a nitric oxide (NO) dioxygenase, metabolizing NO in an oxygen (O2)-dependent manner.	Oxygen	126-128	cytoglobin	Homo sapiens	12-16
28228237-9	2017	Denitrification of NO3- to N2 occurred in anaerobic conditions, while at intermediate dissolved oxygen; N2O was the dominant reaction product.	Oxygen	96-102	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
28432138-4	2017	Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in Abeta-treated neurons.	Oxygen	110-116	dynamin 1-like	Mus musculus	14-18
28237221-4	2017	Chemical Oxygen Demand (COD) removal efficiency of 90% was achieved for synthetic textile wastewater (initial COD - 780 mg L-1) at a flow rate of 500 mL h-1 (retention time of 6 h) and a current density of 1.15 mA cm-2 and the energy consumption for the degradation was 9.2 kWh (kg COD)-1.	Oxygen	9-15	immunoglobulin kappa variable 1-16	Homo sapiens	123-126
28277081-6	2017	The addition of 1 mL min-1 hydrogen peroxide has shown complete CBF degradation and 76% chemical oxygen demand removal under the following operating conditions of CBF ~50 mg L-1, TiO2 ~5 mg L-1 and feed flow rate ~82.5 mL min-1.	Oxygen	97-103	CD59 molecule (CD59 blood group)	Homo sapiens	21-26
28497799-0	2017	Corrigendum: Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1alpha.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
33440492-4	2017	We show that calcium peroxide physically cross-links gellan gum into a hydrogel, which when loaded with catalase raises the dissolved oxygen content of media for up to 64 h. Additionally, doxorubicin could be loaded into the hydrogel in situ, allowing release in well-defined quantities.	Oxygen	134-140	catalase	Homo sapiens	104-112
28469167-5	2017	In the mouse model of oxygen-induced retinopathy (OIR), pericytes become the predominant CCN1 producing cells.	Oxygen	22-28	cellular communication network factor 1	Mus musculus	89-93
27982675-6	2017	We hypothesized that responsiveness of VEGFRs in the major end organs of plateau animals is differential with insult of hypoxic stress and is modulated by low oxygen sensitive HIF-1alpha.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-186
27496203-1	2017	AIM: We studied whether available oxygen without induced mechanical stretch regulates the release of the biologically active B-type natriuretic peptide (BNP) from Langendorff heart.	Oxygen	34-40	natriuretic peptide B	Rattus norvegicus	125-151
27496203-1	2017	AIM: We studied whether available oxygen without induced mechanical stretch regulates the release of the biologically active B-type natriuretic peptide (BNP) from Langendorff heart.	Oxygen	34-40	natriuretic peptide B	Rattus norvegicus	153-156
27496203-6	2017	RESULTS: A low oxygen concentration in the perfusate was associated with a significant increase in BNP release (F = 40.4, P &lt; 0.001).	Oxygen	15-21	natriuretic peptide B	Rattus norvegicus	99-102
27496203-8	2017	There was also a significant but inverse correlation between BNP and oxygen in the coronary flow (R2  = 0.27, P &lt; 0.001).	Oxygen	69-75	natriuretic peptide B	Rattus norvegicus	61-64
27496203-9	2017	CONCLUSION: In the spontaneously beating Langendorff rat heart, a decreasing concentration of oxygen in the ingoing perfusion increased the secretion of BNP.	Oxygen	94-100	natriuretic peptide B	Rattus norvegicus	153-156
28270443-6	2017	Specifically, an increase in the plateau at which O2 uptake (Vo2) did not change from baseline with increasing treadmill speed [peak Vo2 (DeltaVo2max)] was maintained in trained mice with PGC-1beta overexpression in muscle 6 wk after cessation of training.	Oxygen	50-52	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	188-197
27496203-11	2017	The difference in the oxygen capacitance of blood and Krebs-Henseleit solution appears to be a major factor affecting secretion of BNP, which is correlated with the oxygen tension of myocardial cells and affected both by the oxygen concentration and capacitance of solution perfusing the heart and by the coronary flow.	Oxygen	22-28	natriuretic peptide B	Rattus norvegicus	131-134
27496203-11	2017	The difference in the oxygen capacitance of blood and Krebs-Henseleit solution appears to be a major factor affecting secretion of BNP, which is correlated with the oxygen tension of myocardial cells and affected both by the oxygen concentration and capacitance of solution perfusing the heart and by the coronary flow.	Oxygen	165-171	natriuretic peptide B	Rattus norvegicus	131-134
27496203-11	2017	The difference in the oxygen capacitance of blood and Krebs-Henseleit solution appears to be a major factor affecting secretion of BNP, which is correlated with the oxygen tension of myocardial cells and affected both by the oxygen concentration and capacitance of solution perfusing the heart and by the coronary flow.	Oxygen	165-171	natriuretic peptide B	Rattus norvegicus	131-134
28259641-3	2017	The distinctive C-type (or cbb3) cytochrome c oxidases, which are mostly present in proteobacteria, exhibit a number of unique structural and functional features, including high catalytic activity at low oxygen concentrations.	Oxygen	204-210	cytochrome c, somatic	Homo sapiens	33-45
28361267-2	2017	This has led to the development of pharmacological agents for anti-angiogenesis to disrupt the vascular supply and starve tumor of nutrients and oxygen, primarily through blockade of VEGF/VEGFR signaling.	Oxygen	145-151	vascular endothelial growth factor A	Homo sapiens	183-187
28324021-7	2017	Glucose tolerance and insulin sensitivity were better in CGRP-/- than WT mice, and expired gas analysis revealed greater oxygen consumption by CGRP-/- mice.	Oxygen	121-127	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	143-147
28320085-0	2017	Down-regulation of microRNA-142-5p attenuates oxygen-glucose deprivation and reoxygenation-induced neuron injury through up-regulating Nrf2/ARE signaling pathway.	Oxygen	46-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
28409544-3	2017	The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) regulates cellular adaptation to low oxygen conditions.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
28402148-1	2017	INTRODUCTION: A defining feature of human hemoglobin is its oxygen binding affinity, quantified by the partial pressure of oxygen at which hemoglobin is 50% saturated (p50), and the variability of this parameter over a range of physiological and environmental states.	Oxygen	60-66	nuclear factor kappa B subunit 1	Homo sapiens	168-171
28402148-1	2017	INTRODUCTION: A defining feature of human hemoglobin is its oxygen binding affinity, quantified by the partial pressure of oxygen at which hemoglobin is 50% saturated (p50), and the variability of this parameter over a range of physiological and environmental states.	Oxygen	123-129	nuclear factor kappa B subunit 1	Homo sapiens	168-171
28549090-7	2017	Results: Oxygen and glucose deprivation in RGCs resulted in decreased mitochondrial membrane potential and cytochrome c oxidase activity when compared with normoxic RGCs.	Oxygen	9-15	cytochrome c, somatic	Homo sapiens	107-119
28549090-9	2017	Oxygen and glucose depreavtation induced decreases in cytochrome c activity were partially restored by overexpression or activation of sigma-1r.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	54-66
28328748-8	2017	CONCLUSIONS: This study showed different effects of isoflurane, sevoflurane, and desflurane on mitochondrial functions and highlighted the implication of CypD in the regulation of adenosine diphosphate consumption and complex I-induced radical oxygen species production.	Oxygen	244-250	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	154-158
28810002-8	2017	In both diseases, the change in oxygen levels is a consequence of disturbed blood flow with resulting tissue hypoxia and vascular endothelial growth factor (VEGF) production.	Oxygen	32-38	vascular endothelial growth factor A	Homo sapiens	121-155
28810002-8	2017	In both diseases, the change in oxygen levels is a consequence of disturbed blood flow with resulting tissue hypoxia and vascular endothelial growth factor (VEGF) production.	Oxygen	32-38	vascular endothelial growth factor A	Homo sapiens	157-161
28941528-4	2017	Pathogenic OPA1 gene mutations in DOA and 3 primary mutations of mitochondrial DNA in LHON-induced mitochondrial dysfunction, which in turn leads to increased reactive oxygen species levels in mitochondria and possibly insufficient ATP production.	Oxygen	168-174	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	11-15
28051298-2	2017	These enzymes require molecular oxygen for catalytic activity and, as 2-oxoglutarate (2OG)-dependent oxygenases, are related to the cellular oxygen sensing HIF hydroxylases PHD2 and FIH.	Oxygen	32-38	egl-9 family hypoxia inducible factor 1	Homo sapiens	173-177
28271621-4	2017	c-KIT+ hAFS were isolated from leftover samples of amniotic fluid from prenatal screening and stimulated to enhance EV release (24 hours 20% O2 versus 1% O2 preconditioning).	Oxygen	141-143	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
28271621-4	2017	c-KIT+ hAFS were isolated from leftover samples of amniotic fluid from prenatal screening and stimulated to enhance EV release (24 hours 20% O2 versus 1% O2 preconditioning).	Oxygen	154-156	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
28459376-6	2017	20(S)-Rg3 could decrease the expression of hypoxia-inducible factor 1alpha by upregulation of prolyl hydroxylase domain protein 1 to promoting hypoxia-inducible factor 1alpha ubiquitin-proteasome degradation under normal oxygen levels.	Oxygen	221-227	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-74
28288786-5	2017	These results support a novel connection between HIF-1alpha and Pak4 in hypoxic cancer cells, and provide insights into mechanisms whereby tumors respond to and thrive under oxygen-deficient conditions.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
28445828-2	2017	At 20% O2, the synthesis of HIF-1alpha is balanced by its hydroxylation and proteasomal degradation.	Oxygen	7-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
28332377-7	2017	P50 (partial pressure at which Hb is half saturated with oxygen), which is an indicator of left-shift of oxygen dissociation curve (high oxygen affinity state), was 14.3 mm Hg (reference value 22.6-29.4 mm Hg).	Oxygen	57-63	nuclear factor kappa B subunit 1	Homo sapiens	0-3
28332377-7	2017	P50 (partial pressure at which Hb is half saturated with oxygen), which is an indicator of left-shift of oxygen dissociation curve (high oxygen affinity state), was 14.3 mm Hg (reference value 22.6-29.4 mm Hg).	Oxygen	105-111	nuclear factor kappa B subunit 1	Homo sapiens	0-3
28332377-7	2017	P50 (partial pressure at which Hb is half saturated with oxygen), which is an indicator of left-shift of oxygen dissociation curve (high oxygen affinity state), was 14.3 mm Hg (reference value 22.6-29.4 mm Hg).	Oxygen	105-111	nuclear factor kappa B subunit 1	Homo sapiens	0-3
28497026-6	2017	Here, we show that either long-term (72 h) exposure to hypoxia (1% O2) or elevated expression of CHCHD4 in tumor cells in normoxia leads to perinuclear accumulation of mitochondria, which is dependent on the expression of HIF-1alpha.	Oxygen	67-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	222-232
28051298-2	2017	These enzymes require molecular oxygen for catalytic activity and, as 2-oxoglutarate (2OG)-dependent oxygenases, are related to the cellular oxygen sensing HIF hydroxylases PHD2 and FIH.	Oxygen	101-107	egl-9 family hypoxia inducible factor 1	Homo sapiens	173-177
28279976-2	2017	Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen-independent degradation of HIF-1alpha.	Oxygen	225-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	259-269
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Oxygen	60-66	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Oxygen	192-198	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
28458631-9	2017	Inhibition of the early mitochondrial p53 accumulation by PFT-mu also prevented the abnormalities in mitochondrial morphology and mitochondrial bioenergetics (reduced oxygen consumption rate, maximum respiratory capacity, and adenosine triphosphate synthesis) that develop in DRG and peripheral nerve after cisplatin-treatment.	Oxygen	167-173	tumor protein p53	Homo sapiens	38-41
27914367-3	2017	By employing repeated two-step oxygen (O2) plasma treatment processes with 35 days of recovery periods, we achieved the enhanced functionalization of the CNT surface and the removal of the byproduct of spray-coated SWCNTs that hinders charge transfer and stable CD4+ T cell sensing.	Oxygen	31-37	CD4 molecule	Homo sapiens	262-265
27914367-3	2017	By employing repeated two-step oxygen (O2) plasma treatment processes with 35 days of recovery periods, we achieved the enhanced functionalization of the CNT surface and the removal of the byproduct of spray-coated SWCNTs that hinders charge transfer and stable CD4+ T cell sensing.	Oxygen	39-41	CD4 molecule	Homo sapiens	262-265
28148392-4	2017	We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate.	Oxygen	160-166	microRNA 200a	Homo sapiens	47-55
28299930-0	2017	Cross-Dehydrogenative Coupling of Heterocyclic Scaffolds with Unfunctionalized Aroyl Surrogates by Palladium(II) Catalyzed C(sp2)-H Aroylation through Organocatalytic Dioxygen Activation.	Oxygen	167-175	Sp2 transcription factor	Homo sapiens	123-128
28299930-1	2017	Cross-dehydrogenative coupling of biorelevant heterocyclic scaffolds with arylmethanes for aroylation during Pd(II)-catalyzed C(sp2)-H activation has been achieved through dioxygen activation by NHPI.	Oxygen	172-180	Sp2 transcription factor	Homo sapiens	126-131
28393874-3	2017	Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O2-dependent manner with decreased NO consumption in physiological hypoxia.	Oxygen	121-123	cytoglobin	Homo sapiens	0-4
28394264-3	2017	VEGF is regulated by many factors in the tumor microenvironment including lowered oxygen levels and elevated androgens.	Oxygen	82-88	vascular endothelial growth factor A	Homo sapiens	0-4
28266841-1	2017	To improve the utilization of visible light and reduce photogenerated electron/hole recombination, Ti3+ self-doped TiO2/oxygen-doped graphitic carbon nitride (Ti3+-TiO2/O-g-C3N4) heterojunctions were prepared via hydrothermal treatment of a mixture of g-C3N4 and titanium oxohydride sol obtained from the reaction of TiH2 with H2O2.	Oxygen	120-126	RuvB like AAA ATPase 2	Homo sapiens	317-321
28054425-4	2017	We demonstrate that a loss-of-function mutation in the neuropeptide receptor gene npr-1 and a deletion mutation in the atypical soluble guanylate cyclase gcy-35 O2 sensor interact synergistically to extend worm lifespan.	Oxygen	161-163	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	154-160
28054425-5	2017	The function of npr-1 and gcy-35 in the O2 -sensing neurons AQR, PQR, and URX shortens the lifespan of the worm.	Oxygen	40-42	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	26-32
26619971-5	2017	Chemical anaerobiosis on dechorionation-stimulated phospho-ERK levels and the in vivo effect of anaerobiosis showed that the supply of oxygen also plays a role in ERK signaling.	Oxygen	135-141	extracellular regulated MAP kinase	Bombyx mori	163-166
27796296-7	2017	IL-22 stimulation of hepatocytes incubated in low oxygen led to reduced levels of activated signal transducer and activator of transcription 3 and further downstream effects such as reduced induction of the anti-microbial protein, lipocalin-2.	Oxygen	50-56	signal transducer and activator of transcription 3	Homo sapiens	92-142
30595866-2	2017	PURPOSE: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias.	Oxygen	151-157	superoxide dismutase 1	Homo sapiens	23-43
30595866-2	2017	PURPOSE: Evaluation of superoxide dismutase (SOD) variations as an antioxidant enzyme (with a physiological role in the dismutation of highly reactive oxygen free radicals into oxygen and water) in young patients with cardiac arrhythmias.	Oxygen	151-157	superoxide dismutase 1	Homo sapiens	45-48
27441981-2	2017	Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions.	Oxygen	182-184	neuroglobin	Rattus norvegicus	33-44
27441981-2	2017	Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions.	Oxygen	182-184	cytoglobin	Rattus norvegicus	56-66
27441981-2	2017	Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions.	Oxygen	182-184	cytoglobin	Rattus norvegicus	68-72
27441981-2	2017	Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions.	Oxygen	186-192	cytoglobin	Rattus norvegicus	68-72
28441900-10	2017	In vitro, NFE2L2 was suppressed under severe hypoxia (3% O2) but was clearly up-regulated under mild hypoxia (10% O2).	Oxygen	57-59	NFE2 like bZIP transcription factor 2	Homo sapiens	10-16
28441900-10	2017	In vitro, NFE2L2 was suppressed under severe hypoxia (3% O2) but was clearly up-regulated under mild hypoxia (10% O2).	Oxygen	114-116	NFE2 like bZIP transcription factor 2	Homo sapiens	10-16
28043649-8	2017	GALP significantly increased oxygen consumption, an indirect estimator of metabolic rate, without having any significant effect on motor activity.	Oxygen	29-35	galanin-like peptide	Rattus norvegicus	0-4
28181110-6	2017	The SLP1 thermotolerant yeast exposed to high temperature showed a diminution of 33% of the oxygen consumption in state 4.	Oxygen	92-98	Slp1p	Saccharomyces cerevisiae S288C	4-8
28032259-11	2017	We propose that NQR and AIR12 interact via the quinone, allowing an electron transfer from cytosolic NAD(P)H to apoplastic monodehydroascorbate and control thereby the level of reactive oxygen production and the redox state of the apoplast.	Oxygen	186-192	plasma membrane ascorbate-reducible b-type cytochrome family protein	Glycine max	24-29
28400504-1	2017	Oxygen-dependent regulation of the erythropoietin gene is mediated by the hypoxia-inducible factor (HIF) family of transcription factors.	Oxygen	0-6	erythropoietin	Homo sapiens	35-49
28400504-3	2017	When oxygen is scarce, the PHD enzymes are inactivated, leading to HIF accumulation and upregulation not only of erythropoietin expression, but also the expression of hundreds of other genes, including those coordinating cardiovascular and ventilatory adaptation to hypoxia.	Oxygen	5-11	erythropoietin	Homo sapiens	113-127
27917446-11	2017	Correlation analysis showed serum OC levels were negatively correlated with apnea hyponea index, obstructive apnea index, arousal index, and lowest oxygen saturation.	Oxygen	148-154	bone gamma-carboxyglutamate protein	Homo sapiens	34-36
28490186-7	2017	The selected descriptors are in accordance with the literature, once C10 and C1 are bound or close to the quinone oxygens involved in the production of radical anions (O2- ).	Oxygen	114-121	homeobox C10	Homo sapiens	69-72
28490186-7	2017	The selected descriptors are in accordance with the literature, once C10 and C1 are bound or close to the quinone oxygens involved in the production of radical anions (O2- ).	Oxygen	168-170	homeobox C10	Homo sapiens	69-72
28346371-1	2017	Two transient receptor potential (TRP) channels-TRPA1 and TRPV3-are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity.	Oxygen	116-122	transient receptor potential cation channel subfamily V member 3	Homo sapiens	58-63
28202541-1	2017	The Mga2 and Sre1 transcription factors regulate oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 transcription factors.	Oxygen	49-55	sterol regulatory element binding transcription factor 2	Homo sapiens	227-234
27721400-0	2017	Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells.	Oxygen	83-85	estrogen receptor 1	Homo sapiens	24-41
27721400-2	2017	We previously reported activation of a key oncogenic signaling cascade via mammalian target of rapamycin (mTOR) signaling complex-2 (mTORC2) owing to estrogen receptor (ER-alpha)-dependent augmentation of O2.- within the mitochondria of 17-beta-estradiol (E2)-stimulated breast cancer cells.	Oxygen	205-207	mechanistic target of rapamycin kinase	Homo sapiens	75-104
27721400-2	2017	We previously reported activation of a key oncogenic signaling cascade via mammalian target of rapamycin (mTOR) signaling complex-2 (mTORC2) owing to estrogen receptor (ER-alpha)-dependent augmentation of O2.- within the mitochondria of 17-beta-estradiol (E2)-stimulated breast cancer cells.	Oxygen	205-207	mechanistic target of rapamycin kinase	Homo sapiens	106-110
27721400-2	2017	We previously reported activation of a key oncogenic signaling cascade via mammalian target of rapamycin (mTOR) signaling complex-2 (mTORC2) owing to estrogen receptor (ER-alpha)-dependent augmentation of O2.- within the mitochondria of 17-beta-estradiol (E2)-stimulated breast cancer cells.	Oxygen	205-207	estrogen receptor 1	Homo sapiens	150-167
27721400-2	2017	We previously reported activation of a key oncogenic signaling cascade via mammalian target of rapamycin (mTOR) signaling complex-2 (mTORC2) owing to estrogen receptor (ER-alpha)-dependent augmentation of O2.- within the mitochondria of 17-beta-estradiol (E2)-stimulated breast cancer cells.	Oxygen	205-207	estrogen receptor 1	Homo sapiens	169-177
27721400-9	2017	In addition, we also observed diminished interaction of MnSOD with sirtuin-3, the key mitochondrial deacetylase that deacetylates MnSOD at critical K68 and thereby activates it for scavenging O2.-.	Oxygen	192-194	sirtuin 3	Homo sapiens	67-76
28352301-9	2017	Moreover, overexpression of TKL1 allows for efficient production of erythritol independently from the supplied dissolved oxygen.	Oxygen	121-127	transketolase TKL1	Saccharomyces cerevisiae S288C	28-32
28320353-8	2017	RESULTS: We present the first comprehensive overview of the effects of bona fide low environmental oxygen (hypoxia) and HIF-1alpha activity on ER-alpha abundance and transcriptional activity.	Oxygen	99-105	estrogen receptor 1	Homo sapiens	143-151
28335733-1	2017	BACKGROUND: The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of "relative hypoxia" which stimulates erythropoietin (EPO) production.	Oxygen	27-33	erythropoietin	Homo sapiens	191-205
28335733-1	2017	BACKGROUND: The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of "relative hypoxia" which stimulates erythropoietin (EPO) production.	Oxygen	27-33	erythropoietin	Homo sapiens	207-210
28386234-9	2017	Results: With similar daily energy intake and physical activity, the increases in [Formula: see text]O2peak [NORM: 0.26 +- 0.37 L min-1 (+11.8%) vs. HYP: 0.54 +- 0.34 L min-1 (+26.1%)] and peak O2 pulse (NORM: +13.4% vs. HYP: +25.9%) for HYP were twice-larger than for NORM (p &lt; 0.05).	Oxygen	101-103	CD59 molecule (CD59 blood group)	Homo sapiens	130-135
28386234-9	2017	Results: With similar daily energy intake and physical activity, the increases in [Formula: see text]O2peak [NORM: 0.26 +- 0.37 L min-1 (+11.8%) vs. HYP: 0.54 +- 0.34 L min-1 (+26.1%)] and peak O2 pulse (NORM: +13.4% vs. HYP: +25.9%) for HYP were twice-larger than for NORM (p &lt; 0.05).	Oxygen	101-103	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
27978620-1	2017	The cellular response to hypoxia is orchestrated by HIF-1, a heterodimeric transcription factor composed of an alpha and a beta subunit that enables cell survival under low oxygen conditions by altering the transcription of over 300 genes.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-57
28326310-7	2017	Oxygen uptake after 3 min of squat exercises increased from 339+-40 mL min-1 to 1060+-160 mL min-1 with WBVT and 988+-124 mL min-1 without WBV (p=0.093).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	71-76
28325294-3	2017	The purpose of this study was to examine the expression of POSTN in the ischemic retinas of a mouse model of oxygen-induced retinal NV.	Oxygen	109-115	periostin, osteoblast specific factor	Mus musculus	59-64
28301544-8	2017	Epoxy can cause deformation of the graphite lattice due to the transition of graphite from sp2 to sp3 after the addition of an oxygen atom.	Oxygen	127-133	Sp2 transcription factor	Homo sapiens	91-94
28301544-8	2017	Epoxy can cause deformation of the graphite lattice due to the transition of graphite from sp2 to sp3 after the addition of an oxygen atom.	Oxygen	127-133	Sp3 transcription factor	Homo sapiens	98-101
28386321-10	2017	Similar results were observed in vitro, as aFGF exerted protective effects on endothelial cell integrity by up-regulating junction proteins and PI3K-Akt-Rac1 pathway and down-regulating RhoA expression under oxygen-glucose deprivation/reoxygenation (OGD) conditions.	Oxygen	208-214	fibroblast growth factor 1	Homo sapiens	43-47
28386321-10	2017	Similar results were observed in vitro, as aFGF exerted protective effects on endothelial cell integrity by up-regulating junction proteins and PI3K-Akt-Rac1 pathway and down-regulating RhoA expression under oxygen-glucose deprivation/reoxygenation (OGD) conditions.	Oxygen	208-214	ras homolog family member A	Homo sapiens	186-190
28088722-9	2017	In such a reduced environment (low dissolved oxygen and low redox potential), higher DNRA over the denitrification rate can be attributed to the high C concentration and high TC/NO3--N ratio.	Oxygen	45-51	NBL1, DAN family BMP antagonist	Homo sapiens	178-181
28348480-5	2017	Studies of pulmonary artery endothelial cells in a low-oxygen environment and cardiac muscle cells in an ischemic environment have shown that ghrelin can activate the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway.	Oxygen	55-61	AKT serine/threonine kinase 1	Homo sapiens	197-200
28302994-10	2017	Furthermore, hTSCs cultured in 20% O2 exhibited significantly higher expression of the 3 markers (PPAR-gamma, Sox-9, and Runx-2).	Oxygen	35-37	peroxisome proliferator activated receptor gamma	Homo sapiens	98-108
28302994-10	2017	Furthermore, hTSCs cultured in 20% O2 exhibited significantly higher expression of the 3 markers (PPAR-gamma, Sox-9, and Runx-2).	Oxygen	35-37	RUNX family transcription factor 2	Homo sapiens	121-127
28326310-7	2017	Oxygen uptake after 3 min of squat exercises increased from 339+-40 mL min-1 to 1060+-160 mL min-1 with WBVT and 988+-124 mL min-1 without WBV (p=0.093).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
28326310-7	2017	Oxygen uptake after 3 min of squat exercises increased from 339+-40 mL min-1 to 1060+-160 mL min-1 with WBVT and 988+-124 mL min-1 without WBV (p=0.093).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
28192982-4	2017	With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2.	Oxygen	222-224	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-82
28289716-5	2017	Ptrf deletion also caused decreased mitochondrial function, oxygen consumption, and altered myofiber composition.	Oxygen	60-66	caveolae associated 1	Mus musculus	0-4
28192982-4	2017	With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2.	Oxygen	222-224	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
28272302-10	2017	Oxy-Di-OA significantly suppressed the increases of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (p &lt; 0.05).	Oxygen	0-3	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	59-85
28157264-1	2017	In this study, we proposed high-performance chemically regenerative redox fuel cells (CRRFCs) using NO3- /NO with a nitrogen-doped carbon-felt electrode and a chemical regeneration reaction of NO to NO3- via O2 .	Oxygen	208-210	NBL1, DAN family BMP antagonist	Homo sapiens	199-202
28267794-8	2017	Moreover, three of the normalized viral gene copy numbers (NS1, NS2, and N) correlated significantly with arterial O2 saturation levels.	Oxygen	115-117	NS2	Homo sapiens	64-67
28272302-10	2017	Oxy-Di-OA significantly suppressed the increases of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (p &lt; 0.05).	Oxygen	0-3	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	87-90
28146458-13	2017	Phosphokinase arrays revealed that different O2 concentrations activated distinct sets of cytoprotective and cell death-associated kinases, including mitogen-activated protein kinases, Src kinases, p53, Akt, mitogen-activated and stress-activated kinase, Lyn, Lck, p70S6, signal transducers and activators of transcription 5b and 6, glycogen synthase kinase 3a/b and 5" AMP-activated protein kinases 1/2.	Oxygen	45-47	tumor protein p53	Homo sapiens	198-201
28229599-2	2017	Notably, the configuration of these tetrasubstituted olefins was dominated by the trans-oxopalladation step where the aryl group derived from ArX is located trans to the oxygen attached in the double bond.	Oxygen	170-176	aristaless related homeobox	Homo sapiens	142-145
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Oxygen	127-133	histone PARylation factor 1	Homo sapiens	24-51
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Oxygen	127-133	histone PARylation factor 1	Homo sapiens	53-57
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Oxygen	127-133	poly(ADP-ribose) polymerase 1	Homo sapiens	75-80
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Oxygen	127-133	poly(ADP-ribose) polymerase 1	Homo sapiens	191-196
26938749-6	2017	Serum osteocalcin levels and bone age are negatively correlated with apnea-hypopnea index, oxygen desaturation index, the percentage of the total recorded time spent below 90% oxygen saturation, and Epworth sleepiness scale scores (all P &lt; 0.05).	Oxygen	91-97	bone gamma-carboxyglutamate protein	Homo sapiens	6-17
28177744-8	2017	Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 +- 0.01 L min-1, p &lt; 0.001; 0.52 +- 0.03 L min-1, p &lt; 0.001; 0.35 +- 0.01 L min-1, respectively).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	123-128
28177744-8	2017	Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 +- 0.01 L min-1, p &lt; 0.001; 0.52 +- 0.03 L min-1, p &lt; 0.001; 0.35 +- 0.01 L min-1, respectively).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	159-164
28177744-8	2017	Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 +- 0.01 L min-1, p &lt; 0.001; 0.52 +- 0.03 L min-1, p &lt; 0.001; 0.35 +- 0.01 L min-1, respectively).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	159-164
28534058-1	2017	BACKGROUND: Catalase enzyme is usually distributed in mammalian seminal plasma, where it decomposes hydrogen peroxide into water and oxygen and enhances sperm survivability.	Oxygen	133-139	catalase	Homo sapiens	12-20
28146458-13	2017	Phosphokinase arrays revealed that different O2 concentrations activated distinct sets of cytoprotective and cell death-associated kinases, including mitogen-activated protein kinases, Src kinases, p53, Akt, mitogen-activated and stress-activated kinase, Lyn, Lck, p70S6, signal transducers and activators of transcription 5b and 6, glycogen synthase kinase 3a/b and 5" AMP-activated protein kinases 1/2.	Oxygen	45-47	AKT serine/threonine kinase 1	Homo sapiens	203-206
28146458-13	2017	Phosphokinase arrays revealed that different O2 concentrations activated distinct sets of cytoprotective and cell death-associated kinases, including mitogen-activated protein kinases, Src kinases, p53, Akt, mitogen-activated and stress-activated kinase, Lyn, Lck, p70S6, signal transducers and activators of transcription 5b and 6, glycogen synthase kinase 3a/b and 5" AMP-activated protein kinases 1/2.	Oxygen	45-47	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	255-258
27903434-4	2017	The primary key factor mediating the mammalian hypoxic response is hypoxia inducible factor (HIF)-1, which regulates oxygen homeostasis on cellular, tissue and organism level.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-99
27893932-6	2017	In this conceptual model, the density of rain is increased by solution of surface salts, transporting near-surface oxygenated NO3- bearing water downward where it encounters reducing conditions and mixes with oxygen-free ascending geologic brines.	Oxygen	115-121	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
28110220-6	2017	In immunoblot assays, the expression of HIF-1alpha was lowly detected in whole and nuclear lysates of RCC cell lines even under normoxia (20% O2), and their expression in whole lysates was increased under hypoxia (1% O2).	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
28110220-6	2017	In immunoblot assays, the expression of HIF-1alpha was lowly detected in whole and nuclear lysates of RCC cell lines even under normoxia (20% O2), and their expression in whole lysates was increased under hypoxia (1% O2).	Oxygen	217-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
27930438-8	2017	Furthermore, CRF assessed by volume oxygen peak was associated with insulin levels (r = -0.273; P &lt; 0.05), the SD of the NN interval series (r = 0.268, P &lt; 0.05) and the long-term variation using the Poincare plot (PS1: r = 0.275, P &lt; 0.05; PS2: r = 0.273, P &lt; 0.05).	Oxygen	36-42	insulin	Homo sapiens	68-75
27930438-8	2017	Furthermore, CRF assessed by volume oxygen peak was associated with insulin levels (r = -0.273; P &lt; 0.05), the SD of the NN interval series (r = 0.268, P &lt; 0.05) and the long-term variation using the Poincare plot (PS1: r = 0.275, P &lt; 0.05; PS2: r = 0.273, P &lt; 0.05).	Oxygen	36-42	taste 2 receptor member 64 pseudogene	Homo sapiens	250-253
28115494-8	2017	Involvement of HIF1A and EPAS1 (also known as HIF2A), two HIF isoforms expressed in trophoblasts, was shown by treating another group of cells cultured under 2.5% O2 with specific inhibitors of HIF1A and EPAS1 for 16 h. INHA mRNA expression was assessed by real-time PCR and secreted inhibin A was quantified by ELISA.	Oxygen	163-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-20
26820681-0	2017	Combining Normobaric Oxygen with Ethanol or Hypothermia Prevents Brain Damage from Thromboembolic Stroke via PKC-Akt-NOX Modulation.	Oxygen	21-27	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
28115494-12	2017	Main Results and the Role of Chance: HIF1 protein stabilization with DMOG and DFX increased 21% O2-induced INHA mRNA and protein upregulation (P &lt; 0.05 versus control), while hypoxia-induced INHA upregulation was repressed by HIF1A and EPAS1 inhibitors (P &lt; 0.05 versus control).	Oxygen	96-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-41
28115494-1	2017	Study Question: Are hypoxia-inducible factors (HIF) responsible for the potentiation of inhibin alpha subunit (INHA) gene expression in primary cultures of human term cytotrophoblasts under low-oxygen tension?	Oxygen	194-200	inhibin subunit alpha	Homo sapiens	88-109
28115494-3	2017	What Is Known Already: During the in vitro differentiation of cytotrophoblasts into syncytiotrophoblasts under 21% O2, INHA expression increases.	Oxygen	115-117	inhibin subunit alpha	Homo sapiens	119-123
28115494-12	2017	Main Results and the Role of Chance: HIF1 protein stabilization with DMOG and DFX increased 21% O2-induced INHA mRNA and protein upregulation (P &lt; 0.05 versus control), while hypoxia-induced INHA upregulation was repressed by HIF1A and EPAS1 inhibitors (P &lt; 0.05 versus control).	Oxygen	96-98	inhibin subunit alpha	Homo sapiens	107-111
28115494-12	2017	Main Results and the Role of Chance: HIF1 protein stabilization with DMOG and DFX increased 21% O2-induced INHA mRNA and protein upregulation (P &lt; 0.05 versus control), while hypoxia-induced INHA upregulation was repressed by HIF1A and EPAS1 inhibitors (P &lt; 0.05 versus control).	Oxygen	96-98	inhibin subunit alpha	Homo sapiens	194-198
28115494-12	2017	Main Results and the Role of Chance: HIF1 protein stabilization with DMOG and DFX increased 21% O2-induced INHA mRNA and protein upregulation (P &lt; 0.05 versus control), while hypoxia-induced INHA upregulation was repressed by HIF1A and EPAS1 inhibitors (P &lt; 0.05 versus control).	Oxygen	96-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	229-234
28115494-13	2017	In transfection experiments of primary term cytotrophoblasts, cloned INHA promoter transcriptional activity was increased by 2.5% O2 compared to 21% O2 (P &lt; 0.05).	Oxygen	130-132	inhibin subunit alpha	Homo sapiens	69-73
28115494-13	2017	In transfection experiments of primary term cytotrophoblasts, cloned INHA promoter transcriptional activity was increased by 2.5% O2 compared to 21% O2 (P &lt; 0.05).	Oxygen	149-151	inhibin subunit alpha	Homo sapiens	69-73
28115494-14	2017	Overexpression of both HIF1A and EPAS1 under 21% O2 increased cloned INHA transcriptional activity (P &lt; 0.001 versus control).	Oxygen	49-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
28115494-14	2017	Overexpression of both HIF1A and EPAS1 under 21% O2 increased cloned INHA transcriptional activity (P &lt; 0.001 versus control).	Oxygen	49-51	inhibin subunit alpha	Homo sapiens	69-73
28122357-0	2017	Activation of Akt by SC79 protects myocardiocytes from oxygen and glucose deprivation (OGD)/re-oxygenation.	Oxygen	55-61	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
28184944-9	2017	Then, activation of HspB6 induced the angiogenesis process which provides necessary nutrition and oxygen for tumor cells.	Oxygen	98-104	heat shock protein family B (small) member 6	Homo sapiens	20-25
28092125-3	2017	RB/UCNP@ROS successfully inhibits Abeta self-assembly under NIR irradiation by generating 1 O2 .	Oxygen	92-94	amyloid beta precursor protein	Homo sapiens	34-39
28292469-3	2017	METHODS: Human BeWo choriocarcinoma cells were treated with the hypoxia mimetic, cobalt chloride (CoCl2), or 3% oxygen for 24-48 h. Activation of HIF-1alpha signaling and regulation of BCRP was assessed using qPCR, ELISA, western blotting and a fluorescent substrate transport assay.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
28292469-5	2017	RESULTS: CoCl2 and 3% oxygen increased HIF-1alpha protein signaling and decreased the mRNA and protein expression of BCRP by 30-75% in BeWo cells.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
28292469-5	2017	RESULTS: CoCl2 and 3% oxygen increased HIF-1alpha protein signaling and decreased the mRNA and protein expression of BCRP by 30-75% in BeWo cells.	Oxygen	22-28	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	117-121
28292469-7	2017	A number of transcription factors known to regulate BCRP, including AHR, NRF2 and PPARgamma, were also coordinately down-regulated by 3% oxygen in BeWo cells.	Oxygen	137-143	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	52-56
28292469-7	2017	A number of transcription factors known to regulate BCRP, including AHR, NRF2 and PPARgamma, were also coordinately down-regulated by 3% oxygen in BeWo cells.	Oxygen	137-143	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
28292469-7	2017	A number of transcription factors known to regulate BCRP, including AHR, NRF2 and PPARgamma, were also coordinately down-regulated by 3% oxygen in BeWo cells.	Oxygen	137-143	peroxisome proliferator activated receptor gamma	Homo sapiens	82-91
28250970-16	2017	ALI-induced improvement of oxygen supply reduced nuclear HIF-1alpha, demonstrating a major change in the transcriptional response.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
28128570-5	2017	In this study, we calculated potentials of mean force for water, ammonia, urea, molecular oxygen, and methanol across the urea transporter B (UT-B) and aquaporin-1 (AQP1), using 3D-RISM, as well as using MD simulations and umbrella sampling.	Oxygen	90-96	aquaporin 1 (Colton blood group)	Homo sapiens	152-163
28235070-5	2017	The bottom waters of virtually all of the eastern half of the bay were below the depth of the mixed layer, and the lowest bottom water oxygen concentrations, 3-5 mg L-1, were found in that part of the bay.	Oxygen	135-141	immunoglobulin kappa variable 1-16	Homo sapiens	165-168
28952497-5	2017	In this paper, we report on synergistic effects of inorganic cerium oxide (IV) nanoparticles conjugated with the antioxidative enzymes superoxide dismutase and catalase on scavenging oxygen and nitrogen radicals.	Oxygen	183-189	catalase	Homo sapiens	160-168
28128570-5	2017	In this study, we calculated potentials of mean force for water, ammonia, urea, molecular oxygen, and methanol across the urea transporter B (UT-B) and aquaporin-1 (AQP1), using 3D-RISM, as well as using MD simulations and umbrella sampling.	Oxygen	90-96	aquaporin 1 (Colton blood group)	Homo sapiens	165-169
27772541-6	2017	After treatment with BM-MSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by upregulating protein kinase B/mammalian target of rapamycin (AKT/mTOR) expression in an oxygen- and glucose-deprived (OGD) environment.	Oxygen	192-198	vascular endothelial growth factor A	Homo sapiens	87-91
28231837-8	2017	RESULTS: PBMCs from nAMD patients secreted higher levels of IL-8, CCL2 and VEGF, especially following LPS and 1% oxygen stimulation, than those from controls.	Oxygen	113-119	vascular endothelial growth factor A	Homo sapiens	75-79
28115238-0	2017	NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway.	Oxygen	21-27	nerve growth factor	Homo sapiens	0-3
28115238-0	2017	NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway.	Oxygen	21-27	mitogen-activated protein kinase kinase 7	Homo sapiens	124-127
28115238-0	2017	NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway.	Oxygen	21-27	mitogen-activated protein kinase 1	Homo sapiens	128-131
28211523-0	2017	PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.	Oxygen	122-128	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	0-4
27772541-6	2017	After treatment with BM-MSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by upregulating protein kinase B/mammalian target of rapamycin (AKT/mTOR) expression in an oxygen- and glucose-deprived (OGD) environment.	Oxygen	192-198	mechanistic target of rapamycin kinase	Homo sapiens	134-163
27772541-6	2017	After treatment with BM-MSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by upregulating protein kinase B/mammalian target of rapamycin (AKT/mTOR) expression in an oxygen- and glucose-deprived (OGD) environment.	Oxygen	192-198	AKT serine/threonine kinase 1	Homo sapiens	165-168
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	vascular endothelial growth factor A	Homo sapiens	139-144
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	insulin like growth factor 1	Homo sapiens	146-150
28231837-8	2017	RESULTS: PBMCs from nAMD patients secreted higher levels of IL-8, CCL2 and VEGF, especially following LPS and 1% oxygen stimulation, than those from controls.	Oxygen	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
28092936-5	2017	DBP formation generally decreased significantly with BAC treatment at 15 min EBCT, but little further reduction was observed at higher EBCT where low dissolved oxygen concentrations may have limited biological activity.	Oxygen	160-166	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
28112911-5	2017	Data from H2 temperature-programmed reduction and O core-level X-ray photoelectron spectra (XPS) reveal that Ag1/HMO possesses a great amount of active surface lattice oxygen available for benzene oxidation.	Oxygen	168-174	thioredoxin domain containing 12	Homo sapiens	109-116
28112911-7	2017	Therefore, the excellent activation abilities of Ag1/HMO toward both surface lattice oxygen and gaseous oxygen account for its high catalytic activity in benzene oxidation.	Oxygen	85-91	thioredoxin domain containing 12	Homo sapiens	49-52
28112911-7	2017	Therefore, the excellent activation abilities of Ag1/HMO toward both surface lattice oxygen and gaseous oxygen account for its high catalytic activity in benzene oxidation.	Oxygen	104-110	thioredoxin domain containing 12	Homo sapiens	49-52
28134531-2	2017	This metal-free spirocyclization process is suggested to encompass a sequential C(sp2)-C(sp) and C(sp2)-N bond formation with the concomitant introduction of a carbonyl oxygen.	Oxygen	169-175	Sp2 transcription factor	Homo sapiens	80-85
28134531-2	2017	This metal-free spirocyclization process is suggested to encompass a sequential C(sp2)-C(sp) and C(sp2)-N bond formation with the concomitant introduction of a carbonyl oxygen.	Oxygen	169-175	Sp2 transcription factor	Homo sapiens	97-102
28011628-2	2017	Responses to reduced oxygen levels (hypoxia) rely on the conserved hypoxia-inducible factor 1 (HIF-1).	Oxygen	21-27	similar	Drosophila melanogaster	67-93
28011628-2	2017	Responses to reduced oxygen levels (hypoxia) rely on the conserved hypoxia-inducible factor 1 (HIF-1).	Oxygen	21-27	similar	Drosophila melanogaster	95-100
28011628-4	2017	To visualise and analyse HIF-1 dynamics in Drosophila, we used a hypoxia biosensor consisting of GFP fused to the oxygen-dependent degradation domain (ODD) of the HIF-1 homologue Sima.	Oxygen	114-120	similar	Drosophila melanogaster	163-168
28131773-2	2017	The degradation of FBXL5 itself is regulated in an iron- and oxygen-responsive manner through its diiron center containing Hr-like domain.	Oxygen	61-67	F-box and leucine rich repeat protein 5	Homo sapiens	19-24
28011628-5	2017	GFP-ODD responds to changing oxygen levels and to genetic manipulations of the hypoxia pathway, reflecting oxygen-dependent regulation of HIF-1 at the single-cell level.	Oxygen	29-35	similar	Drosophila melanogaster	138-143
28131773-3	2017	Although the crystal structure of the Hr-like domain of FBXL5 and its degradation based on iron/oxygen sensing has been reported, the redox sensing molecular mechanism is still not clear.	Oxygen	96-102	F-box and leucine rich repeat protein 5	Homo sapiens	56-61
28011628-5	2017	GFP-ODD responds to changing oxygen levels and to genetic manipulations of the hypoxia pathway, reflecting oxygen-dependent regulation of HIF-1 at the single-cell level.	Oxygen	107-113	similar	Drosophila melanogaster	138-143
27940158-0	2017	Inactivation of maternal Hif-1alpha at mid-pregnancy causes placental defects and deficits in oxygen delivery to the fetal organs under hypoxic stress.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
28239356-5	2017	The maximal oxygen uptake [Formula: see text] was higher in men than in women [4,492 +- 585 ml min-1 and 57.7 +- 4.4 ml kg-1 min-1 vs. 2,752.4 +- 187.9 ml min-1 (p &lt;= 0.001) and 50.0 +- 5.7 ml kg-1 min-1(p = 0.007), respectively].	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
28199842-1	2017	Oxygen-dependent HIF1alpha hydroxylation and degradation are strictly controlled by PHD2.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-26
28199842-1	2017	Oxygen-dependent HIF1alpha hydroxylation and degradation are strictly controlled by PHD2.	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	84-88
28199842-2	2017	In hypoxia, HIF1alpha partly escapes degradation because of low oxygen availability.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-21
28239356-5	2017	The maximal oxygen uptake [Formula: see text] was higher in men than in women [4,492 +- 585 ml min-1 and 57.7 +- 4.4 ml kg-1 min-1 vs. 2,752.4 +- 187.9 ml min-1 (p &lt;= 0.001) and 50.0 +- 5.7 ml kg-1 min-1(p = 0.007), respectively].	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
28239356-5	2017	The maximal oxygen uptake [Formula: see text] was higher in men than in women [4,492 +- 585 ml min-1 and 57.7 +- 4.4 ml kg-1 min-1 vs. 2,752.4 +- 187.9 ml min-1 (p &lt;= 0.001) and 50.0 +- 5.7 ml kg-1 min-1(p = 0.007), respectively].	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
28239356-5	2017	The maximal oxygen uptake [Formula: see text] was higher in men than in women [4,492 +- 585 ml min-1 and 57.7 +- 4.4 ml kg-1 min-1 vs. 2,752.4 +- 187.9 ml min-1 (p &lt;= 0.001) and 50.0 +- 5.7 ml kg-1 min-1(p = 0.007), respectively].	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
28148750-9	2017	This is analogous to the evolutionary adaptation of haemoglobin to the needs of O2 transport across the animal kingdom and supports the hypothesis that Cx26 is an important and universal CO2 sensor in homeotherms.	Oxygen	80-82	gap junction protein beta 2	Homo sapiens	152-156
28178996-6	2017	Reduced cardiac output in the moderate and mild in silico ARDS patients produced significant drops in oxygen delivery during the RM (average decrease of 423 ml min-1 and 526 ml min-1, respectively).	Oxygen	102-108	CD59 molecule (CD59 blood group)	Homo sapiens	160-165
28178996-6	2017	Reduced cardiac output in the moderate and mild in silico ARDS patients produced significant drops in oxygen delivery during the RM (average decrease of 423 ml min-1 and 526 ml min-1, respectively).	Oxygen	102-108	CD59 molecule (CD59 blood group)	Homo sapiens	177-182
28178996-7	2017	In the in-silico patients with severe ARDS, however, significantly improved gas-exchange led to an average increase of 89 ml min-1 in oxygen delivery during the RM, despite a simultaneous fall in cardiac output of more than 3 l min-1 on average.	Oxygen	134-140	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
28178996-9	2017	In patients with high baseline cardiac outputs (&gt;6.5 l min-1), oxygen delivery never fell below 700 ml min-1.	Oxygen	66-72	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
28132831-4	2017	These microdomain Ca2+ transients were facilitated by the production of reactive oxygen species during oxidative phosphorylation and were enhanced by expression of a mutant form of superoxide dismutase 1 (SOD1 G93A) that causes astrocyte dysfunction and neurodegeneration in amyotrophic lateral sclerosis (ALS).	Oxygen	81-87	superoxide dismutase 1, soluble	Mus musculus	205-209
28038470-3	2017	Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level.	Oxygen	10-16	egl-9 family hypoxia inducible factor 1	Homo sapiens	149-153
28038470-3	2017	Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level.	Oxygen	10-16	epidermal growth factor receptor	Homo sapiens	158-162
28038470-3	2017	Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level.	Oxygen	10-16	egl-9 family hypoxia inducible factor 1	Homo sapiens	24-69
28038470-6	2017	Overall, we introduce for the first time the direct crosstalk between the oxygen sensor PHD2 and EGFR-mediated tumorigenesis in breast cancer.	Oxygen	74-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	88-92
28038470-3	2017	Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level.	Oxygen	10-16	egl-9 family hypoxia inducible factor 1	Homo sapiens	71-75
28038470-3	2017	Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
28038470-6	2017	Overall, we introduce for the first time the direct crosstalk between the oxygen sensor PHD2 and EGFR-mediated tumorigenesis in breast cancer.	Oxygen	74-80	epidermal growth factor receptor	Homo sapiens	97-101
27858176-1	2017	We have shown that serum levels of reactive oxygen metabolites (ROM) were associated with C-reactive protein (CRP) and disease activity score based on the examination of 28 joints (DAS28) in patients with rheumatoid arthritis (RA); however, their clinical significance as biomarkers has not been elucidated.	Oxygen	44-50	C-reactive protein	Homo sapiens	90-108
27332955-5	2017	A subgroup of 15 subjects continued with 3-min cycling exercise in hypoxia with subsequent evaluation followed by an assessment 1 min at rest while breathing 4 L min-1 oxygen.	Oxygen	168-174	CD59 molecule (CD59 blood group)	Homo sapiens	162-167
28057606-10	2017	Comparatively, the estimation of p50 by blood gas analyzers on venous blood is a much more convenient and attractive method but due to the lack of proof as to its effectiveness in the diagnosis of hemoglobins with high oxygen affinity, it requires further investigations.	Oxygen	219-225	nuclear factor kappa B subunit 1	Homo sapiens	33-36
28179300-9	2017	In summary, the results presented here provide a novel finding of STAT3 inhibitor activity under hypoxic conditions and indicate that under such low oxygen conditions, the anticancer efficacy of STAT3 inhibitors was indeed hampered.	Oxygen	149-155	signal transducer and activator of transcription 3	Homo sapiens	66-71
28179300-9	2017	In summary, the results presented here provide a novel finding of STAT3 inhibitor activity under hypoxic conditions and indicate that under such low oxygen conditions, the anticancer efficacy of STAT3 inhibitors was indeed hampered.	Oxygen	149-155	signal transducer and activator of transcription 3	Homo sapiens	195-200
28203702-4	2017	For ex vivo hypoxia treatment, uterine arteries from normoxic animals were treated with 21.0% O2 or 10.5% O2 for 48 h. High-altitude hypoxia significantly upregulated DNMT3b expression and enzyme activity in uterine arteries.	Oxygen	94-96	DNA (cytosine-5)-methyltransferase 3B	Ovis aries	167-173
27888296-7	2017	In cell culture, activation of neuronal TLR2 induced an inflammatory response, including the secretion of inflammatory cytokines and microglial-activating chemokines, as well as the production of reactive oxygen species.	Oxygen	205-211	toll like receptor 2	Homo sapiens	40-44
27858176-1	2017	We have shown that serum levels of reactive oxygen metabolites (ROM) were associated with C-reactive protein (CRP) and disease activity score based on the examination of 28 joints (DAS28) in patients with rheumatoid arthritis (RA); however, their clinical significance as biomarkers has not been elucidated.	Oxygen	44-50	C-reactive protein	Homo sapiens	110-113
28215263-7	2017	Leptin correlated with oxygen desaturation index (r = -0.17, p = 0.03), adiponectin correlated with mean oxygen saturation (r = 0.24, p = 0.002) and with the percentage of sleep time with an oxygen saturation &gt;95% (r = 0.25, p = 0.001).	Oxygen	105-111	adiponectin, C1Q and collagen domain containing	Homo sapiens	72-83
28282048-4	2017	Isotopic labelling confirms that the carbon and oxygen atoms of CO2 originate from CS2 and H2O, respectively, and reaction intermediates were observed by gas-phase and electrospray ionization mass spectrometry, as well as by Fourier transform infrared spectroscopy.	Oxygen	48-54	chorionic somatomammotropin hormone 2	Homo sapiens	83-86
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	14-26
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	66-78
27979921-1	2017	Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping.	Oxygen	90-92	cytochrome c, somatic	Homo sapiens	80-85
27904934-0	2017	Part-2: Analytical Expressions of Concentrations of Glucose, Oxygen, and Gluconic Acid in a Composite Membrane for Closed-Loop Insulin Delivery for the Non-steady State Conditions.	Oxygen	61-67	insulin	Homo sapiens	127-134
28038356-1	2017	The hypoxia inducible factor 1 (HIF1) is a heterodimeric transcription factor that ultimately regulates cellular responses to changes in oxygen tension.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
28038356-1	2017	The hypoxia inducible factor 1 (HIF1) is a heterodimeric transcription factor that ultimately regulates cellular responses to changes in oxygen tension.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-36
27835826-0	2017	Reactive oxygen species-driven HIF1alpha triggers accelerated glycolysis in endothelial cells exposed to low oxygen tension.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-40
28215263-7	2017	Leptin correlated with oxygen desaturation index (r = -0.17, p = 0.03), adiponectin correlated with mean oxygen saturation (r = 0.24, p = 0.002) and with the percentage of sleep time with an oxygen saturation &gt;95% (r = 0.25, p = 0.001).	Oxygen	105-111	adiponectin, C1Q and collagen domain containing	Homo sapiens	72-83
27881662-5	2017	Moreover, cells lacking PC1 expression use less O2 and show less mitochondrial Ca2+ uptake in response to bradykinin-induced ER Ca2+ release, indicating that PC1 can modulate mitochondrial function.	Oxygen	48-50	kininogen 1	Homo sapiens	106-116
28032976-11	2017	Thus, reorientation/protonation steps in ferrous THB1 appear to present a significant barrier for dioxygen binding, and consequently, NOD turnover.	Oxygen	98-106	uncharacterized protein	Chlamydomonas reinhardtii	49-53
28039311-7	2017	Sleep-disordered breathing was more severe in participants with cognitive impairment with an apnea/hypopnea index (AHI) of 18.0 (7.8-35.5)/h (p50 [p25-p75]) (vs 12.9 [7.2-24.5]/h, p &lt; 0.001), and higher oxygen desaturation index (ODI).	Oxygen	206-212	nuclear factor kappa B subunit 1	Homo sapiens	142-145
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Oxygen	69-75	Eph receptor B1	Rattus norvegicus	119-122
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Oxygen	69-75	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Oxygen	69-75	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-145
28120861-4	2017	By comparing the molecular responses of macrophages derived from THP1 monocytes to both types of CNTs, we highlight a molecular mechanism regulated by Nrf2/Bach1 signaling pathways to induce CNT degradation via NOX2 complex activation and O2 -, H2O2 and OH  production.	Oxygen	239-241	GLI family zinc finger 2	Homo sapiens	65-69
28120861-4	2017	By comparing the molecular responses of macrophages derived from THP1 monocytes to both types of CNTs, we highlight a molecular mechanism regulated by Nrf2/Bach1 signaling pathways to induce CNT degradation via NOX2 complex activation and O2 -, H2O2 and OH  production.	Oxygen	239-241	NFE2 like bZIP transcription factor 2	Homo sapiens	151-155
28120861-4	2017	By comparing the molecular responses of macrophages derived from THP1 monocytes to both types of CNTs, we highlight a molecular mechanism regulated by Nrf2/Bach1 signaling pathways to induce CNT degradation via NOX2 complex activation and O2 -, H2O2 and OH  production.	Oxygen	239-241	BTB domain and CNC homolog 1	Homo sapiens	156-161
28106050-3	2017	By fusing an oxygen sensitive subdomain of HIF1alpha to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-52
27909249-7	2017	These findings reveal an ERK-controlled, unconventional and anti-apoptotic function of HIF-1alpha that might serve as an early protective mechanism upon oxygen limitation and promote cancer cell resistance to chemotherapy.	Oxygen	153-159	mitogen-activated protein kinase 1	Homo sapiens	25-28
27909249-7	2017	These findings reveal an ERK-controlled, unconventional and anti-apoptotic function of HIF-1alpha that might serve as an early protective mechanism upon oxygen limitation and promote cancer cell resistance to chemotherapy.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
27865763-5	2017	The study showed that aerobic treatment reduced respiration activity (final values 0.9-1.1mgO2/gTS) and residual methane potential (1.1LCH4/kgTS) better than anaerobic methods (1.8-2.3mg O2/g TS and 1.3-2.4L CH4/kg TS, respectively).	Oxygen	92-94	GTS	Homo sapiens	95-98
28255270-3	2017	The alteration of ClC-2 expression in various developmental stages of cerebral white matter with/without being exposed to high glucose was analyzed using RT-PCR, active oxygen detection, TUNEL staining, Western Blot as well as immuno-histochemical staining.	Oxygen	169-175	chloride voltage-gated channel 2	Rattus norvegicus	18-23
28084425-4	2017	In epididymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated, resulting in "browning" phenotype, with a smaller increases in body weight under high-fat diet, smaller fat deposits, increased beta-oxidation of fatty acids (FAO) and oxygen consumption.	Oxygen	353-359	phosphodiesterase 3B, cGMP-inhibited	Mus musculus	45-50
27579789-2	2017	When adding p-NP into Ag NCs, an obvious color change from pale yellow to deep yellow could be observed by naked eyes, accompanying with an apparent red-shift of absorption peak, and the reason was attributed to the formation of oxygen anion of p-NP based on the transfer of H+ from p-NP to amine groups of PEI.	Oxygen	229-235	purine nucleoside phosphorylase	Homo sapiens	12-16
27579789-2	2017	When adding p-NP into Ag NCs, an obvious color change from pale yellow to deep yellow could be observed by naked eyes, accompanying with an apparent red-shift of absorption peak, and the reason was attributed to the formation of oxygen anion of p-NP based on the transfer of H+ from p-NP to amine groups of PEI.	Oxygen	229-235	purine nucleoside phosphorylase	Homo sapiens	245-249
27579789-2	2017	When adding p-NP into Ag NCs, an obvious color change from pale yellow to deep yellow could be observed by naked eyes, accompanying with an apparent red-shift of absorption peak, and the reason was attributed to the formation of oxygen anion of p-NP based on the transfer of H+ from p-NP to amine groups of PEI.	Oxygen	229-235	purine nucleoside phosphorylase	Homo sapiens	245-249
28085964-4	2017	The kinetic parametors kcat, Vmax and kcat/Km in the OPH reaction were remarkably increased in the buffers (pH 8.0, 25 C) containing aminoalcohols with C2 between nitrogen (N) and oxygen (O) in their structures, including triethanolamine (TEA), diethanolamine, monoethanolamine, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and triisopropanolamine.	Oxygen	180-186	acylaminoacyl-peptide hydrolase	Homo sapiens	53-56
27966954-1	2017	The discovery of a novel potent type II ABL/c-KIT dual kinase inhibitor compound 34 (CHMFL-ABL/KIT-155), which utilized a hydrogen bond formed by NH on the kinase backbone and carbonyl oxygen of 34 as a unique hinge binding, is described.	Oxygen	185-191	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	44-49
27936573-2	2017	With increasing of the oxygen partial pressure, the crystal lattice of Ga1.4Sn0.6O3 films expands due to tin ions valence changes from Sn4+ to Sn2+.	Oxygen	23-29	solute carrier family 38 member 5	Homo sapiens	143-146
28079178-6	2017	Two of the most promising O2-transporters (Homo sapiens AQP1 and Nicotiana tabacum PIP1;3) were confirmed to facilitate O2 transport in the spectrophotometric assay using yeast protoplasts.	Oxygen	26-28	aquaporin 1 (Colton blood group)	Homo sapiens	56-60
27936662-5	2017	The strong electron-phonon coupling of the vanadia particles has been proposed to create the O - radicals (V5+ = O2-+ heat   V4+-O -) for the n &gt; 25 clusters with Delta = -2, -1, 0, and 2.	Oxygen	113-115	delta like non-canonical Notch ligand 1	Homo sapiens	166-190
28685439-4	2017	In this study two-photon phosphorescence lifetime microscopy (2PLM) was used to determine and define the tissue oxygen tension field within the cerebral cortex of mice to a cortical depth of between 200-250 mum under normoxia and acute hypoxia (FiO2 = 0.10).	Oxygen	112-118	FXYD domain-containing ion transport regulator 1	Mus musculus	63-66
27773695-0	2017	Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1alpha.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-63
27773695-5	2017	Oxygen cycles, within the physiological range, were sufficient to synchronize cellular clocks in a HIF1alpha-dependent manner.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
27773695-6	2017	Furthermore, several clock genes responded to changes in oxygen levels through HIF1alpha.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-88
27773695-8	2017	We conclude that oxygen, via HIF1alpha activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-38
27773695-8	2017	We conclude that oxygen, via HIF1alpha activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-38
28116225-0	2017	Hyperbaric Oxygen Therapy for the Compromised Graft or Flap.	Oxygen	11-17	arachidonate 5-lipoxygenase activating protein	Homo sapiens	55-59
29129868-3	2017	After optimization of the reaction cell gas, it was found that the best performance for measuring BaF+ could be achieved at a flow rate of O2 in the range from 0.65 to 0.75 mL min-1.	Oxygen	139-141	BAF nuclear assembly factor 1	Homo sapiens	98-101
28215043-4	2017	Oxygen at 6 L min-1 was administered by a facial mask.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	14-19
28362031-11	2017	The automatic group consumed more anaesthetic and oxygen per minute (sevoflurane 0.1171 mL min-1; IQR: 0.0503; oxygen 1.8286 mL min-1, IQR: 1,3751) than MANUAL-ET (sevoflurane 0.0824 mL min-1, IQR: 0.0305; oxygen 1,288 mL min-1, IQR: 0,6517) (P = 0.0028 and P = 0.0171, respectively).	Oxygen	50-56	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
28889269-4	2017	The amyloid precursor protein (APP) and the amyloid beta (Abeta) peptide both have Cu binding sites, and interaction with Cu can lead to potentially neurotoxic outcomes through generation of reactive oxygen species.	Oxygen	200-206	amyloid beta precursor protein	Homo sapiens	44-56
29129868-3	2017	After optimization of the reaction cell gas, it was found that the best performance for measuring BaF+ could be achieved at a flow rate of O2 in the range from 0.65 to 0.75 mL min-1.	Oxygen	139-141	CD59 molecule (CD59 blood group)	Homo sapiens	176-181
27914786-3	2017	Batch experiments indicated that low dissolved oxygen (DO&lt;0.3mg L-1) greatly repressed the ammonium oxidizing bacteria (AOB) but only slightly inhibited the nitrite oxidizing bacteria (NOB).	Oxygen	47-53	immunoglobulin kappa variable 1-16	Homo sapiens	67-70
27605567-9	2017	RESULTS: Absence of a minor allele in 2 IL6 SNPs was associated with fecal calprotectin ( p = .0222, p = .0429), length of stay ( p = .0158), SNAPPE-II ( p = .0497), weight gain ( p = .0272), and days on oxygen ( p = .0316).	Oxygen	204-210	interleukin 6	Homo sapiens	40-43
28395329-6	2017	Using annexin-V as a marker of released MP assessed by flow cytometry and cytochrome c reduction assay to measure EC superoxide generation, we found that MP release and superoxide generation were significantly increased when cells were cultured under 2%O2, which could be significantly inhibited by 1,25(OH)2D3.	Oxygen	253-255	cytochrome c, somatic	Homo sapiens	74-86
28395329-9	2017	We found that under lowered oxygen condition, 1,25(OH)2D3 could upregulate EC eNOS, p-eNOSSer1177, and p-AktSer473 expression, but inhibit cleaved ROCK1 expression.	Oxygen	28-34	nitric oxide synthase 3	Homo sapiens	78-82
28675894-0	2017	Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome.	Oxygen	4-10	interleukin 6	Homo sapiens	85-89
28675894-5	2017	RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p &lt; 0.05).	Oxygen	174-180	interleukin 6	Homo sapiens	37-40
28675894-5	2017	RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p &lt; 0.05).	Oxygen	174-180	interleukin 6	Homo sapiens	126-130
27864359-11	2017	The roles of tumor necrosis factor (TNF)-alpha (25 ng/ml) and oxygen (1%) in ET-1 regulation of MMP14 and 15 expression were assessed by Western blotting.	Oxygen	62-68	endothelin 1	Homo sapiens	77-81
27388246-3	2017	Animal models of oxygen-induced retinopathy studies have shown vascular endothelial growth factor (VEGF) to be a key player in the pathogenesis of ROP.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	63-97
27388246-3	2017	Animal models of oxygen-induced retinopathy studies have shown vascular endothelial growth factor (VEGF) to be a key player in the pathogenesis of ROP.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	99-103
28857653-3	2017	The activity of HIF-1 is largely regulated by the abundance of its alpha subunit (HIF-1alpha), which is primarily regulated by an oxygen-dependent and ubiquitin/proteasome-mediated degradation process.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
28857653-3	2017	The activity of HIF-1 is largely regulated by the abundance of its alpha subunit (HIF-1alpha), which is primarily regulated by an oxygen-dependent and ubiquitin/proteasome-mediated degradation process.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
27748176-2	2017	While VEGF can have positive effects on hyperglycemia stressed retinal tissues, it also plays a role in events progressing to the oxygen- stressed, i.e. hypoxic, diabetic retina.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	6-10
27890795-3	2017	This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2.	Oxygen	282-284	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	140-143
27612012-6	2017	In addition, TIA-1 increased mitochondrial activity, including the rate of ATP synthesis and oxygen consumption.	Oxygen	93-99	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	13-18
27645688-12	2017	Genetic and epigenetic abnormalities of this oxygen-sensing pathway can trigger normoxic activation of HIF-1alpha and can promote abnormal metabolism and cell proliferation.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
29531793-2	2017	During cancer progression, VEGF production is often increased to stimulate the growth of new blood vessels to supply growing tumors with the additional oxygen and nutrients they require.	Oxygen	152-158	vascular endothelial growth factor A	Homo sapiens	27-31
28509314-7	2017	RESULTS: CD4+CD28+ and CD8+CD28+ cells from the whole study group were characterized by shorter time required to enter the first (G1) phase of the first cell cycle at 21% compared to 10% O2.	Oxygen	187-189	CD4 molecule	Homo sapiens	9-12
28509314-11	2017	Compared to males, the female CD4+ cells showed increased susceptibility to apoptosis at both O2 concentrations.	Oxygen	94-96	CD4 molecule	Homo sapiens	30-33
28509314-13	2017	CONCLUSIONS: We showed that in vitro female T cells (both CD4+ and CD8+ cells) are more sensitive than male lymphocytes to low O2 concentration as demonstrated by the decrease in their proliferation dynamics.	Oxygen	127-129	CD4 molecule	Homo sapiens	58-61
27658702-0	2017	Oxygen tension modulates the effects of TNFalpha in compressed chondrocytes.	Oxygen	0-6	tumor necrosis factor	Homo sapiens	40-48
27658702-2	2017	We examined whether low oxygen tension influenced the cells response to TNFalpha and dynamic compression.	Oxygen	24-30	tumor necrosis factor	Homo sapiens	72-80
27658702-6	2017	RESULTS: TNFalpha dose-dependently increased NO, PGE2 and MMP activity (all p &lt; 0.001) and induced MMP-13 (p &lt; 0.05) and ADAMTS-5 gene expression (pp &lt; 0.01) with values greater at 5 % oxygen tension than 21 %.	Oxygen	194-200	tumor necrosis factor	Homo sapiens	9-17
27658702-9	2017	CONCLUSIONS: The present findings revealed that TNFalpha increased production of NO, PGE2 and MMP activity at 5 % oxygen tension.	Oxygen	114-120	tumor necrosis factor	Homo sapiens	48-56
27658702-11	2017	Future therapeutics should develop oxygen-sensitive antagonists which are directed to interfering with the TNFalpha-induced pathways.	Oxygen	35-41	tumor necrosis factor	Homo sapiens	107-115
27848178-1	2017	The TET dioxygenases, TET1, TET2, and TET3, catalyze transfer of an oxygen atom to the methyl group of 5-methylcytocine (5-mC), converting it to 5-hydroxymethylcytocine (5-hmC).	Oxygen	10-16	tet methylcytosine dioxygenase 3	Homo sapiens	38-42
27902963-1	2017	BACKGROUND: Hypoxia-inducible factor 2 alpha (HIF2alpha), prolyl hydroxylase domain protein 2 (PHD2), and the von Hippel Lindau tumor suppressor protein (pVHL) are three principal proteins in the oxygen-sensing pathway.	Oxygen	196-202	egl-9 family hypoxia inducible factor 1	Homo sapiens	58-93
27237220-4	2017	The CP-H group was exposed to 1.25 atmospheres absolute with 36% oxygen for 3 h daily for 16 weeks.	Oxygen	65-71	carboxypeptidase E	Rattus norvegicus	4-8
28115125-4	2017	The similar dependence of wavelength and oxygen for photochemical production of COS, CS2 and DMS implied that they might be from the same precursors.	Oxygen	41-47	chorionic somatomammotropin hormone 2	Homo sapiens	85-88
27815979-2	2017	FIH activates O2 via oxidative decarboxylation of alpha-ketoglutarate (alphaKG) to generate an enzyme-based oxidant which hydroxylates the Asn803 residue within the C-terminal transactivation domain (CTAD) of HIF-1alpha.	Oxygen	14-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-219
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Oxygen	90-96	egl-9 family hypoxia inducible factor 1	Homo sapiens	79-83
27377914-2	2017	In healthy individuals, exercise and improved aerobic fitness (peak oxygen uptake; peak VO2) increases IGF-1 in circulation.	Oxygen	68-74	insulin like growth factor 1	Homo sapiens	103-108
30615357-5	2017	Under obesity, increasing of number of insulin-depended subcutaneous adipocytes results in: a) increasing of volume of distal part of arterial channel; b) slowing down of bloodstream, biological reaction metabolism-micro-circulation is disturbing, O2 clearance decreases, excretion of catabolites is deranged; c) multiplicity of blood turnover in capillaries is decreased; d) implementation of biological functions of homeostasis, trophology, biological function of endoecology and adaptation are disordered.	Oxygen	248-250	insulin	Homo sapiens	39-46
27529351-10	2017	Sod1 and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.	Oxygen	97-99	superoxide dismutase 1, soluble	Mus musculus	0-4
27529351-10	2017	Sod1 and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.	Oxygen	97-99	interleukin 1 beta	Mus musculus	9-13
27233446-2	2017	It has been shown that insulin resistance impairs glucose metabolism and mitochondrial function, thus increasing production of reactive oxygen species.	Oxygen	136-142	insulin	Homo sapiens	23-30
28845732-10	2017	The observed hyperbaric oxygen-induced reductions in glial cell activation and neuroinflammation, as indicated by the production of TNF-alpha, IL-1beta, and fractalkine, were also prominently diminished in the group with kindlin-1 overexpression.	Oxygen	24-30	tumor necrosis factor	Rattus norvegicus	132-141
28845732-10	2017	The observed hyperbaric oxygen-induced reductions in glial cell activation and neuroinflammation, as indicated by the production of TNF-alpha, IL-1beta, and fractalkine, were also prominently diminished in the group with kindlin-1 overexpression.	Oxygen	24-30	interleukin 1 beta	Rattus norvegicus	143-151
28376500-0	2017	Suppression of Retinal Neovascularization by Anti-CCR3 Treatment in an Oxygen-Induced Retinopathy Model in Mice.	Oxygen	71-77	chemokine (C-C motif) receptor 3	Mus musculus	50-54
27865879-0	2017	Arachidonic acid has protective effects on oxygen-glucose deprived astrocytes mediated through enhancement of potassium channel TREK-1 activity.	Oxygen	43-49	potassium two pore domain channel subfamily K member 2	Homo sapiens	128-134
28123527-11	2017	Our results showed that compared with normoxia condition, under anoxia condition (3% O2), the expression levels of the contractile phenotype marker proteins decreased significantly after 24 and 48 h. The positive rate of the EdU staining increased significantly and the expression of miR-23a increased.	Oxygen	85-87	microRNA 23a	Rattus norvegicus	284-291
28376500-1	2017	PURPOSE: To investigate the association between retinal neovascularization and the CC chemokine receptor-3 (CCR3) in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	134-140	chemokine (C-C motif) receptor 3	Mus musculus	83-106
28376500-1	2017	PURPOSE: To investigate the association between retinal neovascularization and the CC chemokine receptor-3 (CCR3) in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	134-140	chemokine (C-C motif) receptor 3	Mus musculus	108-112
28593021-1	2017	Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen.	Oxygen	143-149	cytochrome c, somatic	Homo sapiens	0-12
28593021-1	2017	Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen.	Oxygen	143-149	cytochrome c, somatic	Homo sapiens	127-139
28607561-0	2017	The Transcription Factor Nrf2 Protects Angiogenic Capacity of Endothelial Colony-Forming Cells in High-Oxygen Radical Stress Conditions.	Oxygen	103-109	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
27440799-2	2017	We sought to investigate the gender differences in the association between WBV, coronary blood flow and tissue oxygen delivery index (TODI) in cardiac syndrome X (CSX).	Oxygen	111-117	NK2 homeobox 5	Homo sapiens	163-166
29806034-13	2017	The results support that MnTBAP or catalase may be more effective for the prevention of oxidative stress in oxygen-induced retinopathy.	Oxygen	108-114	catalase	Homo sapiens	35-43
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-152
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	197-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-152
27701121-5	2017	Cellular oxygen consumption rate increased as a function of Mn up to 10 muM and decreased with Mn dose &gt;=50 muM.	Oxygen	9-15	latexin	Homo sapiens	72-75
28819544-4	2017	Cultivation in 1% O2 for 24 h resulted in the strong dephosphorylation of ERK and its upstream kinases and to a lesser extent of Akt in an HIF-1-independent manner, while STAT3 phosphorylation remained unaffected.	Oxygen	18-20	mitogen-activated protein kinase 1	Mus musculus	74-77
28819544-4	2017	Cultivation in 1% O2 for 24 h resulted in the strong dephosphorylation of ERK and its upstream kinases and to a lesser extent of Akt in an HIF-1-independent manner, while STAT3 phosphorylation remained unaffected.	Oxygen	18-20	thymoma viral proto-oncogene 1	Mus musculus	129-132
28819544-4	2017	Cultivation in 1% O2 for 24 h resulted in the strong dephosphorylation of ERK and its upstream kinases and to a lesser extent of Akt in an HIF-1-independent manner, while STAT3 phosphorylation remained unaffected.	Oxygen	18-20	signal transducer and activator of transcription 3	Mus musculus	171-176
27701121-5	2017	Cellular oxygen consumption rate increased as a function of Mn up to 10 muM and decreased with Mn dose &gt;=50 muM.	Oxygen	9-15	latexin	Homo sapiens	111-114
27773243-3	2017	The X-ray structure revealed that the Pb(II) atom is coordinated by one oxygen and three nitrogen atoms from two qcnh ligands and five oxygen atoms from three nitrate ligands in an 8+1 fashion with a PbN3O6 donor set.	Oxygen	72-78	submaxillary gland androgen regulated protein 3B	Homo sapiens	38-44
27773243-3	2017	The X-ray structure revealed that the Pb(II) atom is coordinated by one oxygen and three nitrogen atoms from two qcnh ligands and five oxygen atoms from three nitrate ligands in an 8+1 fashion with a PbN3O6 donor set.	Oxygen	135-141	submaxillary gland androgen regulated protein 3B	Homo sapiens	38-44
28629523-7	2017	These findings suggest that the inhibition of the Epo-EpoR signaling by EMP9 induces the cancer cell death that is mediated by the apoptosis and calcification of the cancer cells as well as the oxygen deficiency through the feeding vessels.	Oxygen	194-200	erythropoietin	Homo sapiens	50-53
27908452-9	2017	This study concludes that NO3- formation during ozonation of DON is induced by an oxygen-transfer to nitrogen forming hydroxylamine and oxime, while NH4+ formation is induced by electron-transfer reactions involving C-centered radicals and imine intermediates.	Oxygen	82-88	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
28629524-2	2017	First, endogenous EPO regulates erythroid cell apoptosis so that red blood cell production is balanced against the number of cells destroyed in order to maintain optimal tissue oxygen levels (i.e., consistent with provision of homeostatic functional signaling information).	Oxygen	177-183	erythropoietin	Homo sapiens	18-21
28247506-12	2017	CONCLUSIONS: Hypoxia (2%-5% oxygen or pO2 : 15.2-38.0 mm Hg) affects the viability, metabolic activity, and insulin secretion of both free and encapsulated APIs over a six-day culture period.	Oxygen	28-34	insulin	Homo sapiens	108-115
28217292-4	2016	Therefore, providing the O2 as soon as possible (NBO treatment), freezing the brain (hypothermia treatment) to slow down ischemia-induced BBB damage or their combined use may extend the time window for the treatment of tPA.	Oxygen	25-27	plasminogen activator, tissue type	Homo sapiens	219-222
27727524-1	2016	Cytochrome P450 enzymes are heme-containing mono-oxygenases that mainly react through oxygen-atom transfer.	Oxygen	49-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
28100855-10	2016	Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase.	Oxygen	54-60	catalase	Homo sapiens	64-72
28036332-8	2016	In contrast, a reduction of 75% and 25% in the transcriptional and translational expression of HIF1alpha respectively (p&lt;0.001) was found for the animals receiving the oxygen nanobubbles.	Oxygen	171-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-104
27984871-1	2016	A nitrate ion (NO3-) with its trigonal planar geometry and charges distributed among nitrogen and oxygen atoms can couple to the extensive hydrogen bond network of water to give rise to unique dynamical characteristics.	Oxygen	98-104	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
28343622-2	2017	Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1alpha).	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
27978745-1	2016	A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10, and C13.	Oxygen	136-142	homeobox C10	Homo sapiens	171-174
27991883-4	2016	Instead, activation of other TLRs, such as TLR2 activation by Pam3CysSK4 (P3C), increased oxygen consumption and mitochondrial enzyme activity.	Oxygen	90-96	toll like receptor 2	Homo sapiens	43-47
27992567-8	2016	Nondiabetic ASC exposition to hypoxia (0.1% oxygen) combined with hyperglycemia (25mM glucose), resulted in a significant increase in VEGF secretion (+64%, p&lt;0.05) with no deleterious impact on KGF release in comparison to physiological conditions (5% oxygen and 5 mM glucose).	Oxygen	44-50	vascular endothelial growth factor A	Homo sapiens	134-138
27992567-8	2016	Nondiabetic ASC exposition to hypoxia (0.1% oxygen) combined with hyperglycemia (25mM glucose), resulted in a significant increase in VEGF secretion (+64%, p&lt;0.05) with no deleterious impact on KGF release in comparison to physiological conditions (5% oxygen and 5 mM glucose).	Oxygen	44-50	fibroblast growth factor 7	Homo sapiens	197-200
27992567-8	2016	Nondiabetic ASC exposition to hypoxia (0.1% oxygen) combined with hyperglycemia (25mM glucose), resulted in a significant increase in VEGF secretion (+64%, p&lt;0.05) with no deleterious impact on KGF release in comparison to physiological conditions (5% oxygen and 5 mM glucose).	Oxygen	255-261	vascular endothelial growth factor A	Homo sapiens	134-138
27982118-1	2016	Hypoxia-inducible factor-1 (HIF-1) is an important transcription factor that induces adaptive responses upon low oxygen conditions in human cancers and triggers off a poor prognostic outcome of conventional treatments.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
27982118-1	2016	Hypoxia-inducible factor-1 (HIF-1) is an important transcription factor that induces adaptive responses upon low oxygen conditions in human cancers and triggers off a poor prognostic outcome of conventional treatments.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
27980207-0	2016	Biaxially strained PtPb/Pt core/shell nanoplate boosts oxygen reduction catalysis.	Oxygen	55-61	protein tyrosine phosphatase receptor type B	Homo sapiens	19-23
28163901-4	2016	Recently, innovative experimental observations have suggested that remote ischaemic preconditioning (RIPC) may be largely mediated through hypoxic inhibition of the oxygen-sensing enzyme PHD2, leading to enhanced levels of alpha-ketoglutarate and subsequent increases in circulating kynurenic acid (KYNA).	Oxygen	165-171	egl-9 family hypoxia inducible factor 1	Homo sapiens	187-191
28031758-5	2016	Significantly lower maximal oxygen uptake (VO2max, ml kg-1 min-1) was observed for GIV (56.6 +- 3.8) compared to GI (59.6 +- 3.9), GII (59.4 +- 4.2) and GIV (59.7 +- 4.1).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
27372571-2	2016	Amphiphilic polymer poly (styrene-co-maleic anhydride) (PSMA) was firstly cooperated with polystyrene (PS) to envelop the highly photostable phosphorescent oxygen indicator, platinum(II)-tetrakis(pentafluorophenyl)porphyrin (PtTFPP, emission at 648nm), and the reference fluorophore, poly(9, 9-dioctylfluorene) (PFO, emission at 440nm ), via hydrophobic interaction in aqueous solution.	Oxygen	156-162	folate hydrolase 1	Homo sapiens	56-60
27966538-3	2016	Here we show a previously undescribed function for NQO1 in stabilizing HIF-1alpha, a master transcription factor of oxygen homeostasis that has been implicated in the survival, proliferation and malignant progression of cancers.	Oxygen	116-122	NAD(P)H quinone dehydrogenase 1	Homo sapiens	51-55
27966538-3	2016	Here we show a previously undescribed function for NQO1 in stabilizing HIF-1alpha, a master transcription factor of oxygen homeostasis that has been implicated in the survival, proliferation and malignant progression of cancers.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
27789221-3	2016	We therefore investigated the effects of LIG on iron uptake protein transferrin receptor 1, iron exporter protein ferroportin 1, iron storage protein ferritin light chain and also hypoxia inducible factor-1 alpha (HIF-1 alpha) in oxygen-glucose deprivation/reoxygenation (OGD/R)-treated SH-SY5Y cells, using Western blot analysis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-212
27844077-2	2016	Heme binds both amyloid beta (Abeta) and human islet amyloid polypeptide (hIAPP) to form heme-Abeta and heme-hIAPP complexes, respectively, and form reactive oxygen species (ROS) like H2O2, O2 -etc., which are known to cause oxidative damage.	Oxygen	190-194	amyloid beta precursor protein	Homo sapiens	30-35
27797510-11	2016	For example, hydrogen peroxide can be decomposed to oxygen by 0.44 U catalase enzyme and semiquantified in the range up to ~1.0 mumol.	Oxygen	52-58	catalase	Homo sapiens	69-77
27783445-5	2016	Cubic fluorite CeO2 exhibited good catalase mimetic activity toward H2 O2 to generate O2 , providing more multiple mimetic enzyme activities of CeO2 NPs for H2 O2 .	Oxygen	17-19	catalase	Homo sapiens	35-43
27966538-4	2016	We demonstrate that NQO1 directly binds to the oxygen-dependent domain of HIF-1alpha and inhibits the proteasome-mediated degradation of HIF-1alpha by preventing PHDs from interacting with HIF-1alpha.	Oxygen	47-53	NAD(P)H quinone dehydrogenase 1	Homo sapiens	20-24
27789221-3	2016	We therefore investigated the effects of LIG on iron uptake protein transferrin receptor 1, iron exporter protein ferroportin 1, iron storage protein ferritin light chain and also hypoxia inducible factor-1 alpha (HIF-1 alpha) in oxygen-glucose deprivation/reoxygenation (OGD/R)-treated SH-SY5Y cells, using Western blot analysis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-225
27966538-4	2016	We demonstrate that NQO1 directly binds to the oxygen-dependent domain of HIF-1alpha and inhibits the proteasome-mediated degradation of HIF-1alpha by preventing PHDs from interacting with HIF-1alpha.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
27966538-4	2016	We demonstrate that NQO1 directly binds to the oxygen-dependent domain of HIF-1alpha and inhibits the proteasome-mediated degradation of HIF-1alpha by preventing PHDs from interacting with HIF-1alpha.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
27733380-6	2016	NFE2L2 binds to antioxidant response elements in the promoters of a variety of antioxidant genes that minimize the opportunities for generation of reactive oxygen intermediates.	Oxygen	156-162	NFE2 like bZIP transcription factor 2	Homo sapiens	0-6
27966538-4	2016	We demonstrate that NQO1 directly binds to the oxygen-dependent domain of HIF-1alpha and inhibits the proteasome-mediated degradation of HIF-1alpha by preventing PHDs from interacting with HIF-1alpha.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
27966538-7	2016	These results collectively reveal a function of NQO1 in the oxygen-sensing mechanism that regulates HIF-1alpha stability in cancers.	Oxygen	60-66	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
27738103-6	2016	Transgenic mice overexpressing Ldhb in muscle (muscle creatine kinase (MCK)-Ldhb) exhibited increased exercise performance and enhanced oxygen consumption during exercise.	Oxygen	136-142	creatine kinase, muscle	Mus musculus	47-69
27738103-6	2016	Transgenic mice overexpressing Ldhb in muscle (muscle creatine kinase (MCK)-Ldhb) exhibited increased exercise performance and enhanced oxygen consumption during exercise.	Oxygen	136-142	creatine kinase, muscle	Mus musculus	71-74
27380303-3	2016	DFT calculations suggested that superior HOMO distributions spread over the nitrogen-donor (as well as somehow oxygen- donor in L2) groups of L1 and L2 macrocycles were the key factor for the observed Kb value enhancement.	Oxygen	111-117	L1 cell adhesion molecule	Homo sapiens	142-151
27694215-0	2016	Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration.	Oxygen	26-32	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	78-83
27694216-1	2016	We tested the hypothesis that dietary nitrate (NO3-)-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation.	Oxygen	135-137	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
27694216-9	2016	NO3- supplementation reduced the O2 cost of moderate-intensity exercise and attenuated the decline in ramp incremental exercise performance following blood donation.	Oxygen	33-35	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
28090139-6	2016	The oxygen conditions and gender had a significant influence on CAT activity.	Oxygen	4-10	catalase	Homo sapiens	64-67
27737800-2	2016	Activation of human macrophages with interleukin (IL)-4 showed that up-regulation of some IL-4 target genes was reduced when macrophages were incubated at 1% oxygen.	Oxygen	158-164	interleukin 4	Homo sapiens	37-55
27737800-2	2016	Activation of human macrophages with interleukin (IL)-4 showed that up-regulation of some IL-4 target genes was reduced when macrophages were incubated at 1% oxygen.	Oxygen	158-164	interleukin 4	Homo sapiens	90-94
27693634-6	2016	In this study, we demonstrated that pVHL inhibits NF-kappaB by mediating K63-ubiquitination of IKKbeta, which is dependent on oxygen.	Oxygen	126-132	nuclear factor kappa B subunit 1	Homo sapiens	50-59
27744020-3	2016	We examined the expressions of periostin splice variants in the ischemic retinas of a mouse model of oxygen-induced retinal NV.	Oxygen	101-107	periostin, osteoblast specific factor	Mus musculus	31-40
27911494-5	2016	The PS2 modification uses two sulfur atoms to replace two non-bridging oxygen atoms at an internucleotide phosphodiester backbone linkage.	Oxygen	71-77	taste 2 receptor member 64 pseudogene	Homo sapiens	4-7
27854125-5	2016	Besides, the apelin/APJ system prevents mitochondrial oxygen damage and lipid peroxidation through nitric oxide formation.	Oxygen	54-60	apelin	Homo sapiens	13-19
27663694-7	2016	In the postanesthesia care unit, O2 flow was started at 5 l min-1 , reduced to 2 and then 0.25 l min-1 every 3 min.	Oxygen	33-35	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
27959879-6	2016	The ratios of nitrogen and oxygen stable isotopes indicated that NO3- contamination of groundwater at Oyu Tolgoi and Tavan Tolgoi was caused by livestock waste.	Oxygen	27-33	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
27840972-0	2016	Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury.	Oxygen	22-28	advanced glycosylation end product-specific receptor	Rattus norvegicus	40-44
27836781-4	2016	In vitro, EsA treatment inhibited APAP- or H2O2-induced cytotoxicity, H2O2 and O2- production, glutathione (GSH) depletion and apoptosis dependent on nuclear factor erythroid-2-related factor 2 (Nrf2) activation in HepG2 cells.	Oxygen	45-47	NFE2 like bZIP transcription factor 2	Homo sapiens	150-193
27836781-4	2016	In vitro, EsA treatment inhibited APAP- or H2O2-induced cytotoxicity, H2O2 and O2- production, glutathione (GSH) depletion and apoptosis dependent on nuclear factor erythroid-2-related factor 2 (Nrf2) activation in HepG2 cells.	Oxygen	45-47	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
27623370-7	2016	The addition of silicone oil at 20% (on a volume basis) stabilized system performance, leading to dissolved O2 concentrations of 7 mg L-1 and steady ECs of 320 g m-3 h-1 in the PB.	Oxygen	108-110	L1 cell adhesion molecule	Homo sapiens	134-137
27663694-7	2016	In the postanesthesia care unit, O2 flow was started at 5 l min-1 , reduced to 2 and then 0.25 l min-1 every 3 min.	Oxygen	33-35	CD59 molecule (CD59 blood group)	Homo sapiens	97-102
27748844-9	2016	Using high resolution respirometry, we observed that the Warburg effect was present in the BCPAP and TPC1 cells, characterized by low oxygen consumption and high reactive oxygen species production.	Oxygen	134-140	two pore segment channel 1	Homo sapiens	101-105
27744530-7	2016	We constructed a second AdRGD vector that expressed oxygen-dependent degradation (ODD)-caspase 3 under the control of the EGFR promoter; the fusion protein contains a core part of the ODD domain of hypoxia inducible factor-1 alpha (HIF-1alpha) fused to caspase 3.	Oxygen	52-58	epidermal growth factor receptor	Canis lupus familiaris	122-126
27826011-5	2016	Hyperglycaemia, hyperlipidaemia and hyperuricaemia can activate the NLRP3 inflammasome, which then mediates the occurrence and development of DN through the K+ channel model, the lysosomal damage model and the active oxygen cluster model.	Oxygen	217-223	NLR family pyrin domain containing 3	Homo sapiens	68-73
27871461-12	2016	NFAT1 and NFAT3 mRNA expression were significantly increased under hypoxia (1% O2).	Oxygen	79-81	nuclear factor of activated T cells 4	Homo sapiens	10-15
27747790-5	2016	RESULTS: Maximal oxygen uptake (VO2max) was 56.17 +- 4.95 and 46.04 +- 3.25 ml kg-1 min-1 in ATL and NATL, respectively.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
27882935-3	2016	Here we show that Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates cutaneous wound healing.	Oxygen	80-86	roundabout guidance receptor 4	Mus musculus	18-23
27965593-3	2016	Here we highlight new aspects of SOD1 physiology that point out some inedited effects of this enzyme in addition to the canonic role of oxygen radical enzymatic dismutation.	Oxygen	136-142	superoxide dismutase 1, soluble	Mus musculus	33-37
27694445-5	2016	Real time analysis of respiratory activity demonstrated that the oxygen consumption rate and activity of mitochondrial complexes were impaired in StarD7-KD cells.	Oxygen	65-71	START domain containing 7	Mus musculus	146-152
27897204-1	2016	In the mitochondria-mediated vicious cycle of Alzheimer"s disease (AD), intracellular amyloid beta (Abeta) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Abeta accumulation.	Oxygen	154-160	amyloid beta precursor protein	Homo sapiens	86-98
27897204-1	2016	In the mitochondria-mediated vicious cycle of Alzheimer"s disease (AD), intracellular amyloid beta (Abeta) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Abeta accumulation.	Oxygen	154-160	amyloid beta precursor protein	Homo sapiens	100-105
27897204-1	2016	In the mitochondria-mediated vicious cycle of Alzheimer"s disease (AD), intracellular amyloid beta (Abeta) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Abeta accumulation.	Oxygen	154-160	amyloid beta precursor protein	Homo sapiens	195-200
29296695-6	2016	Low oxygen levels decrease T-cell proliferation, promote glycolysis, and cause the appearance of a population of PD-1+ and IL-10-secreting T cells.	Oxygen	4-10	IL10	Sus scrofa	123-128
27802058-3	2016	Here we demonstrate a new chelating platform composed of a multidentate high-affinity oxygen-donating ligand 3,4,3-LI(CAM) bound to the mammalian protein siderocalin.	Oxygen	86-92	calmodulin 3	Homo sapiens	118-121
27874067-8	2016	Our results provided the first evidence that 5-HTR as a GPCR and an ion channel, functionally expressed in mitochondria and participated in the mitochondria function and regulation to maintain homeostasis of mitochondrial [Ca2+], ROS, and ATP generation efficiency in cardiomyocytes in response to stress and O2 tension.	Oxygen	309-311	telomerase RNA component	Homo sapiens	47-50
27895592-9	2016	The main result was that the MSIT group substantially improved parameters related to physical capacity (+5.31 +- 5.12 ml min-1/kg in maximal oxygen uptake at T6) in comparison with the MSCTL group (-0.97 +- 4.89 ml min-1/kg at T6; group effect: p = 0.0004).	Oxygen	141-147	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
27875893-5	2016	Comparison with the MeC(H)O study shows that replacing oxygen with sulfur significantly lowers the P required to initiate oligomerization (from 26 GPa to 5 GPa), increases the types of reactions in which systems of this type can take part, and increases the variety of products formed through these reactions.	Oxygen	55-61	C-C motif chemokine ligand 28	Homo sapiens	20-23
27904712-0	2016	Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1beta-induced apoptosis via the PI3K/AKT signaling pathway.	Oxygen	11-17	interleukin 1 beta	Rattus norvegicus	65-82
27904712-0	2016	Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1beta-induced apoptosis via the PI3K/AKT signaling pathway.	Oxygen	11-17	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
27835955-8	2016	The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients.	Oxygen	56-62	interleukin 6	Homo sapiens	27-31
27633738-1	2016	Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production.	Oxygen	65-67	cytochrome c, somatic	Homo sapiens	99-111
26951539-5	2016	Phd-2 is a group of enzymes that acts as an oxygen sensor.	Oxygen	44-50	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-5
27372381-5	2016	Inflamed tissues are characterized by low levels of oxygen and glucose, a microenvironment that triggers the stabilization of the hypoxia-inducible transcription factor HIF-1alpha.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	tumor necrosis factor	Mus musculus	267-276
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	interleukin 1 beta	Mus musculus	278-286
27824128-9	2016	Finally, the Rosa-Lkb1 mice had much reduced oxygen consumption, carbon dioxide production, and energy expenditure.	Oxygen	45-51	serine/threonine kinase 11	Mus musculus	18-22
27749236-3	2016	RESULTS: Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions.	Oxygen	85-91	tumor necrosis factor	Homo sapiens	14-17
27749236-5	2016	CONCLUSIONS: Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.	Oxygen	102-108	tumor necrosis factor	Homo sapiens	18-21
27585216-5	2016	Loss of OPA1 protein function by OPA1 gene mutations causes mitochondrial dysfunction because of the loss of mitochondrial fusion, impaired mitochondrial oxidative phosphorylation, increases in reactive oxygen species, and altered calcium homeostasis.	Oxygen	203-209	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	8-12
27585216-5	2016	Loss of OPA1 protein function by OPA1 gene mutations causes mitochondrial dysfunction because of the loss of mitochondrial fusion, impaired mitochondrial oxidative phosphorylation, increases in reactive oxygen species, and altered calcium homeostasis.	Oxygen	203-209	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	33-37
27633738-1	2016	Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production.	Oxygen	65-67	cytochrome c, somatic	Homo sapiens	0-12
27633738-6	2016	The model predictions show that: 1) the apparent Km of O2 varies considerably and increases from fully reduced to fully oxidized cytochrome c depending on pH and the energy state of mitochondria, and 2) the intermediate enzyme states depend on pH and cytochrome c redox fraction and play a central role in coupling mitochondrial respiration to PMF.	Oxygen	55-57	cytochrome c, somatic	Homo sapiens	129-141
27633738-6	2016	The model predictions show that: 1) the apparent Km of O2 varies considerably and increases from fully reduced to fully oxidized cytochrome c depending on pH and the energy state of mitochondria, and 2) the intermediate enzyme states depend on pH and cytochrome c redox fraction and play a central role in coupling mitochondrial respiration to PMF.	Oxygen	55-57	cytochrome c, somatic	Homo sapiens	251-263
27503671-4	2016	Low oxygen level, referred to as hypoxia, has been independently shown to induce angiogenesis, modulate TGFbeta signalling and promote EndoMT.	Oxygen	4-10	transforming growth factor beta 1	Homo sapiens	104-111
27529445-6	2016	The first model indicated that neurons due to injury with pro-inflammatory agents (IFN-gamma) release soluble neurotoxic factors, including COX-2, reactive oxygen species, and calpain, thus activating microglia, which in turn released neurotoxic factors as well.	Oxygen	156-162	interferon gamma	Homo sapiens	83-92
27426098-0	2016	Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow.	Oxygen	64-70	angiotensinogen	Rattus norvegicus	25-39
27426098-4	2016	Exogenous angiotensin-II reduced renal cortical tissue PO2 more than equi-pressor doses of phenylephrine, probably because it reduced renal oxygen delivery more than did phenylephrine.	Oxygen	140-146	angiotensinogen	Rattus norvegicus	10-24
27426098-7	2016	ABSTRACT: We hypothesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the progression of chronic kidney disease.	Oxygen	121-127	angiotensinogen	Rattus norvegicus	61-75
27426098-7	2016	ABSTRACT: We hypothesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the progression of chronic kidney disease.	Oxygen	121-127	angiotensinogen	Rattus norvegicus	77-82
27426098-13	2016	Oxygen delivery decreased by 50% after infusion of AngII and renal blood flow (RBF) fell by 3.3 ml min-1 .	Oxygen	0-6	angiotensinogen	Rattus norvegicus	51-56
27426098-19	2016	This phenomenon appears to be attributable to the profound impact of AngII on renal oxygen delivery.	Oxygen	84-90	angiotensinogen	Rattus norvegicus	69-74
27434830-5	2016	Interleukin-7 mRNA expression at enrollment in peripheral blood mononuclear cells differed significantly between those with moderate and severe bronchiolitis, and correlated with both the subsequent length of hospital stay and need for supplemental oxygen therapy.	Oxygen	249-255	interleukin 7	Homo sapiens	0-13
27400794-8	2016	Interestingly, a negative relation for VEGF secretion was found when ASCs were contaminated by fibroblasts, especially when cells were exposed to 4.5 g/l glucose and 0.1% O2 (R = -0.521; p &lt; .001).	Oxygen	171-173	vascular endothelial growth factor A	Homo sapiens	39-43
27780532-5	2016	Intriguingly, exposure of mice to non-severe hypoxia (O2 = 12%) between E11.5-E17.5 reduced placental miR-210 expression, with slight expression changes of some miR-210 target mRNAs.	Oxygen	54-56	microRNA 210	Mus musculus	102-109
27780532-5	2016	Intriguingly, exposure of mice to non-severe hypoxia (O2 = 12%) between E11.5-E17.5 reduced placental miR-210 expression, with slight expression changes of some miR-210 target mRNAs.	Oxygen	54-56	microRNA 210	Mus musculus	161-168
27822494-8	2016	CCR3 inhibition or deletion protects murine cortical cultures from oxygen-glucose deprivation-induced cell death, and CCR3 deletion in mice provides protection from ischemia in vivo.	Oxygen	67-73	chemokine (C-C motif) receptor 3	Mus musculus	0-4
27620809-4	2016	Low oxygen tension leads to upregulation of hypoxia-regulated genes (i.e. VEGF), that should help to restore the impaired blood flow.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	74-78
27796314-5	2016	The increase in oxygen diffusivity for (Thx,Pu1-x)O2 is explained in terms of lower oxygen defect formation enthalpies for (Thx,Pu1-x)O2 than PuO2 and ThO2, while links are drawn between the superionic transition temperature and oxygen Frenkel disorder.	Oxygen	16-22	THO complex 2	Homo sapiens	151-155
27796314-5	2016	The increase in oxygen diffusivity for (Thx,Pu1-x)O2 is explained in terms of lower oxygen defect formation enthalpies for (Thx,Pu1-x)O2 than PuO2 and ThO2, while links are drawn between the superionic transition temperature and oxygen Frenkel disorder.	Oxygen	84-90	THO complex 2	Homo sapiens	151-155
27796314-5	2016	The increase in oxygen diffusivity for (Thx,Pu1-x)O2 is explained in terms of lower oxygen defect formation enthalpies for (Thx,Pu1-x)O2 than PuO2 and ThO2, while links are drawn between the superionic transition temperature and oxygen Frenkel disorder.	Oxygen	84-90	THO complex 2	Homo sapiens	151-155
27411540-4	2016	In particular, triply excited states can be largely present in the excited BSA-Ag13 NC and readily sensitized molecular oxygen to produce singlet oxygen (1 O2 ) with a high quantum efficiency ( 1.26 using Rose Bengal as a standard).	Oxygen	120-126	albumin	Homo sapiens	75-78
27637085-6	2016	Increased DUOX2-related VEGF-A expression appears to result from reactive oxygen-mediated activation of ERK signaling that is responsible for AP-1-related transcriptional effects on the VEGF-A promoter.	Oxygen	74-80	dual oxidase 2	Homo sapiens	10-15
27637085-6	2016	Increased DUOX2-related VEGF-A expression appears to result from reactive oxygen-mediated activation of ERK signaling that is responsible for AP-1-related transcriptional effects on the VEGF-A promoter.	Oxygen	74-80	vascular endothelial growth factor A	Homo sapiens	24-30
27637085-6	2016	Increased DUOX2-related VEGF-A expression appears to result from reactive oxygen-mediated activation of ERK signaling that is responsible for AP-1-related transcriptional effects on the VEGF-A promoter.	Oxygen	74-80	mitogen-activated protein kinase 1	Homo sapiens	104-107
27637085-6	2016	Increased DUOX2-related VEGF-A expression appears to result from reactive oxygen-mediated activation of ERK signaling that is responsible for AP-1-related transcriptional effects on the VEGF-A promoter.	Oxygen	74-80	vascular endothelial growth factor A	Homo sapiens	186-192
27867481-5	2016	RIF-1 tumors were hypoxic with a baseline tissue pO2 of 6.2-8.3 mmHg in mice breathing 30% O2.	Oxygen	50-52	replication timing regulatory factor 1	Mus musculus	0-5
27739509-9	2016	5% O2 significantly increased the proliferation rate, migration ability, expression of stem cell markers (CXCR4 and G-CSFR), and expression of SOX2, VEGF, NGF, and BDNF genes of DPSCs.	Oxygen	3-5	vascular endothelial growth factor A	Homo sapiens	149-153
27642068-3	2016	Within an unexpectedly polar active site, CutC orients choline through hydrogen bonding with a putative general base, and through close interactions between phenolic and carboxylate oxygen atoms of the protein scaffold and the polarized methyl groups of the trimethylammonium moiety.	Oxygen	182-188	cutC copper transporter	Homo sapiens	42-46
27617624-6	2016	The formed alpha-(4-nitrocyclohexa-2,4-dien-1-yl) phenylacetamide anion intermediate oxidized by a basic solution of DMSO or atmospheric oxygen led to the desired sp3 C-H and sp2 C-H coupled alpha-(2/4-nitroaryl) phenylacetamides.	Oxygen	137-143	Sp3 transcription factor	Homo sapiens	163-166
27617624-6	2016	The formed alpha-(4-nitrocyclohexa-2,4-dien-1-yl) phenylacetamide anion intermediate oxidized by a basic solution of DMSO or atmospheric oxygen led to the desired sp3 C-H and sp2 C-H coupled alpha-(2/4-nitroaryl) phenylacetamides.	Oxygen	137-143	Sp2 transcription factor	Homo sapiens	175-178
27588494-7	2016	We provide evidence that adipocytes drive metabolic reprogramming of tumor cells via oxygen-independent mechanism of HIF-1alpha activation that can be reversed by HIF-1alpha downregulation.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
27588494-7	2016	We provide evidence that adipocytes drive metabolic reprogramming of tumor cells via oxygen-independent mechanism of HIF-1alpha activation that can be reversed by HIF-1alpha downregulation.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	163-173
27589845-3	2016	We were able to show that low oxygen concentrations consistently lead to the upregulation of miR-210 in different primary TIC-enriched cultures.	Oxygen	30-36	pleckstrin and Sec7 domain containing 4	Homo sapiens	122-125
27411540-4	2016	In particular, triply excited states can be largely present in the excited BSA-Ag13 NC and readily sensitized molecular oxygen to produce singlet oxygen (1 O2 ) with a high quantum efficiency ( 1.26 using Rose Bengal as a standard).	Oxygen	156-158	albumin	Homo sapiens	75-78
27611728-5	2016	In addition, substitution of the hydrogen atom H4 of Phe471 with halogen atoms, in particular the bromine atom Br4, can constitute a geometrically satisfactory halogen bonding with the oxygen atom O of CETP Ile193 residue.	Oxygen	185-191	cholesteryl ester transfer protein	Homo sapiens	202-206
27704869-10	2016	In these, systematic increases were observed for heart rate (~12 beats min-1) and oxygen consumption (~5.7 mL kg-1 min-1).	Oxygen	82-88	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
27545759-6	2016	Therefore, this study demonstrates that the O2 concentration in the microenvironment differentially affects the repressive methylation on K27 and the activating methylation on K4 at the INK4a locus by inhibiting the H3K27me3 and H3K4me3 demethylases.	Oxygen	44-46	cyclin dependent kinase inhibitor 2A	Homo sapiens	186-191
28077536-8	2016	The cerebral tissue oxygen saturation measured with FORE-SIGHT  started at 68 (sd 13)% and increased by 0.0142% min-1 (P&lt;0.01).	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	112-117
27485932-6	2016	By contrast, in HDAC4/TM transformed cells, glycolysis is only modestly up-regulated, lactate secretion is not augmented and, instead, mitochondrial oxygen consumption is increased.	Oxygen	149-155	histone deacetylase 4	Mus musculus	16-21
27499495-1	2016	Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen).	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
27591797-1	2016	Regulation of ROS metabolism plays a major role in cellular adaptation to oxidative stress in cancer cells, but the molecular mechanism that regulates catalase, a key antioxidant enzyme responsible for conversion of hydrogen peroxide to water and oxygen, remains to be elucidated.	Oxygen	247-253	catalase	Homo sapiens	151-159
27521459-0	2016	Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy.	Oxygen	79-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
27499160-8	2016	Overexpression of hypoxia-inducible factor-1alpha (HIF-1alpha) increased Malat1 expression in 21% O2 conditions, whereas pharmacological inhibition of HIF-1alpha blocked the impact of hypoxia on the Malat1 promoter.	Oxygen	98-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-49
27499160-8	2016	Overexpression of hypoxia-inducible factor-1alpha (HIF-1alpha) increased Malat1 expression in 21% O2 conditions, whereas pharmacological inhibition of HIF-1alpha blocked the impact of hypoxia on the Malat1 promoter.	Oxygen	98-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
27289409-0	2016	Oxygen Therapy in Patients With Acute Heart Failure: Friend or Foe?	Oxygen	0-6	WAPL cohesin release factor	Homo sapiens	63-66
27609199-2	2016	Our previous work showed that chronic hypoxia induces the oxygen-sensing enzyme heme oxygenase-1 (HO-1) within the C1 sympathoexcitatory region and the pre-Botzinger complex (pre-BotC).	Oxygen	58-64	heme oxygenase 1	Mus musculus	80-96
27609199-2	2016	Our previous work showed that chronic hypoxia induces the oxygen-sensing enzyme heme oxygenase-1 (HO-1) within the C1 sympathoexcitatory region and the pre-Botzinger complex (pre-BotC).	Oxygen	58-64	heme oxygenase 1	Mus musculus	98-102
27756077-0	2016	The Systemic Blood Pressure and Oxygen Saturation in Retinal Arterioles Predict the Effect of Intravitreal Anti-VEGF Treatment on Diabetic Maculopathy.	Oxygen	32-38	vascular endothelial growth factor A	Homo sapiens	112-116
27756077-3	2016	The purpose of the present study was to test the hypothesis that the oxygen saturation in retinal vessels together with other risk factors can predict the effect of anti-VEGF treatment on diabetic maculopathy.	Oxygen	69-75	vascular endothelial growth factor A	Homo sapiens	170-174
27756077-8	2016	Conclusions: The MAP and oxygen saturation in retinal arterioles might potentially be included as parameters in risk models predicting the effect of anti-VEGF treatment in patients with diabetic maculopathy.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	154-158
27526028-5	2016	A single glucuronic acid-beta1,3-xylose disaccharide repeat straddles a Ca(2+) ion in the LG4 domain, with oxygen atoms from both sugars replacing Ca(2+)-bound water molecules.	Oxygen	107-113	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	25-32
27588920-0	2016	Oxygen-Content-Controllable Graphene Oxide from Electron-Beam-Irradiated Graphite: Synthesis, Characterization, and Removal of Aqueous Lead [Pb(II)].	Oxygen	0-6	submaxillary gland androgen regulated protein 3B	Homo sapiens	141-148
27335160-5	2016	Under the optimized conditions, 4.14 +- 0.19 g/L of TRAIL in soluble form was achieved at 19 h without pure oxygen.	Oxygen	108-114	TNF superfamily member 10	Homo sapiens	52-57
27170156-6	2016	In the brain, in microvascular endothelial cells, bFGF treatment increased the levels of junction proteins, caveolin-1 small interfering RNA abolished the protective effect of bFGF under oxygen-glucose deprivation conditions, and the expression of fibroblast growth factor receptor 1 and co-localization with caveolin-1 decreased significantly, which could not be reversed by bFGF treatment.	Oxygen	187-193	caveolin 1	Rattus norvegicus	108-118
27503656-7	2016	An anaerobiosis-responsive green fluorescent protein reporter gene for lactate dehydrogenase was induced in the region of the gel where the measured oxygen concentrations were low, confirming biologically relevant hypoxia.	Oxygen	149-155	AT695_RS04475	Staphylococcus aureus	71-92
28163959-6	2017	RESULTS: There was significant (P &lt; 0.05) reduction in the activity of catalase, superoxide dismutase, and glutathione peroxidase with concomitant reduction in oxygen radical absorbance capacity in ischemic rat heart of control compared to group pre-treated with KV, respectively.	Oxygen	163-169	catalase	Rattus norvegicus	74-82
27662095-2	2016	The later discoveries that erythropoietin and VEGF levels adapt to oxygen levels launched a new field aimed at understanding how cells sense and respond to normal- and low-oxygen environments.	Oxygen	67-73	erythropoietin	Homo sapiens	27-41
27662095-2	2016	The later discoveries that erythropoietin and VEGF levels adapt to oxygen levels launched a new field aimed at understanding how cells sense and respond to normal- and low-oxygen environments.	Oxygen	67-73	vascular endothelial growth factor A	Homo sapiens	46-50
27662095-2	2016	The later discoveries that erythropoietin and VEGF levels adapt to oxygen levels launched a new field aimed at understanding how cells sense and respond to normal- and low-oxygen environments.	Oxygen	172-178	erythropoietin	Homo sapiens	27-41
27662095-2	2016	The later discoveries that erythropoietin and VEGF levels adapt to oxygen levels launched a new field aimed at understanding how cells sense and respond to normal- and low-oxygen environments.	Oxygen	172-178	vascular endothelial growth factor A	Homo sapiens	46-50
27141964-1	2016	Adaptation to hypoxia depends on a conserved alpha/beta heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose alpha-subunit is regulated by oxygen through different concurrent mechanisms.	Oxygen	166-172	similar	Drosophila melanogaster	98-122
32263759-4	2016	Herein, we report an oxygen delivery functional material by using hollow mesoporous silica nanoparticles (HMSNs) as carriers, synthesizing sodium percarbonate (SPC) in the channels and cavity of HMSNs (SPC@HMSNs) and coating polyacrylic acid (PAA) on the functional materials (SPC@HMSNs-PAA).	Oxygen	21-27	surfactant protein C	Homo sapiens	160-163
32263759-4	2016	Herein, we report an oxygen delivery functional material by using hollow mesoporous silica nanoparticles (HMSNs) as carriers, synthesizing sodium percarbonate (SPC) in the channels and cavity of HMSNs (SPC@HMSNs) and coating polyacrylic acid (PAA) on the functional materials (SPC@HMSNs-PAA).	Oxygen	21-27	surfactant protein C	Homo sapiens	202-211
32263759-4	2016	Herein, we report an oxygen delivery functional material by using hollow mesoporous silica nanoparticles (HMSNs) as carriers, synthesizing sodium percarbonate (SPC) in the channels and cavity of HMSNs (SPC@HMSNs) and coating polyacrylic acid (PAA) on the functional materials (SPC@HMSNs-PAA).	Oxygen	21-27	surfactant protein C	Homo sapiens	277-286
32263759-5	2016	SPC@HMSNs-PAA could release more SPC in a simulated tumor acidic microenvironment (pH ~ 6.5), which can provide oxygen to improve radiotherapy outcome even under low energy X-ray irradiation.	Oxygen	112-118	surfactant protein C	Homo sapiens	0-9
32263759-5	2016	SPC@HMSNs-PAA could release more SPC in a simulated tumor acidic microenvironment (pH ~ 6.5), which can provide oxygen to improve radiotherapy outcome even under low energy X-ray irradiation.	Oxygen	112-118	surfactant protein C	Homo sapiens	0-3
27141964-1	2016	Adaptation to hypoxia depends on a conserved alpha/beta heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose alpha-subunit is regulated by oxygen through different concurrent mechanisms.	Oxygen	166-172	similar	Drosophila melanogaster	124-127
27141964-6	2016	Thus, Musashi is a novel regulator of HIF that inhibits responses to hypoxia specifically when oxygen is available.	Oxygen	95-101	musashi	Drosophila melanogaster	6-13
27141964-6	2016	Thus, Musashi is a novel regulator of HIF that inhibits responses to hypoxia specifically when oxygen is available.	Oxygen	95-101	similar	Drosophila melanogaster	38-41
27585373-7	2016	Theoretical studies show crossing from the high-spin to low-spin surface upon neutral oxygen atom transfer from the nitrate ligand in [MnO2(NO3)](-) allows formation of (1)[MnO4](-).	Oxygen	86-92	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
27503933-7	2016	Our results define ILK as a key mechanotransducer in modulating breast CSC development in response to tissue mechanics and oxygen tension.	Oxygen	123-129	integrin linked kinase	Homo sapiens	19-22
27385075-2	2016	Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-1alpha by prolyl hydroxylase domain enzymes (PHDs) is an important step for controlling the expression of oxygen-regulated genes in metazoan species, thereby constituting a molecular mechanism for oxygen sensing and response.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-71
27385075-2	2016	Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-1alpha by prolyl hydroxylase domain enzymes (PHDs) is an important step for controlling the expression of oxygen-regulated genes in metazoan species, thereby constituting a molecular mechanism for oxygen sensing and response.	Oxygen	171-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-71
27385075-2	2016	Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-1alpha by prolyl hydroxylase domain enzymes (PHDs) is an important step for controlling the expression of oxygen-regulated genes in metazoan species, thereby constituting a molecular mechanism for oxygen sensing and response.	Oxygen	262-268	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-71
27585373-4	2016	Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand.	Oxygen	75-81	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
27585373-4	2016	Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand.	Oxygen	75-81	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
27611801-9	2016	Taken together, a novel MDH2 inhibitor, compound 7, suppressed HIF-1alpha accumulation via reduction of oxygen consumption and ATP production, integrating metabolism into anti-cancer efficacy in cancer cells.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
27600662-2	2016	In this study, a novel, facile method to synthesize these chalcohalides, including BiSBr1-xIx solid solutions, at low temperatures was developed via the substitution of anions from O(2-) to S(2-) (or Se(2-)) using bismuth oxyhalide precursors.	Oxygen	181-186	fucosyltransferase 2	Homo sapiens	200-206
27533734-1	2016	An unprecedented C(8)-H bond allylation of quinoline with allyl carbonate and allyl alcohol catalyzed by Cp*Co(III) using a traceless directing group via beta-oxygen and beta-hydroxy elimination is described.	Oxygen	159-165	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	108-115
30034766-3	2016	Thus, the intracellular levels of O2 - and H2O2 can directly be controlled through regulating SOD1 activity.	Oxygen	34-36	superoxide dismutase 1	Homo sapiens	94-98
27488030-0	2016	Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.	Oxygen	9-15	interleukin 6	Homo sapiens	31-44
27476419-5	2016	In vitro antiproliferative activity and Hsp90 binding affinity of the compounds were determined, suggesting the C18-oxygen of herbimycin A is removable and bulky lipophilic groups can be accommodated at C15 without loss of activity.	Oxygen	116-122	Bardet-Biedl syndrome 9	Homo sapiens	112-115
30034766-4	2016	Here, based on the active site structure and catalytic mechanism of SOD1, we developed a new type of efficient and specific SOD1 inhibitors which can directly change the intracellular levels of H2O2 and O2 -.	Oxygen	196-198	superoxide dismutase 1	Homo sapiens	68-72
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	175-177	superoxide dismutase 1	Homo sapiens	42-46
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	175-177	superoxide dismutase 1	Homo sapiens	73-77
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	175-177	superoxide dismutase 1	Homo sapiens	73-77
30034766-4	2016	Here, based on the active site structure and catalytic mechanism of SOD1, we developed a new type of efficient and specific SOD1 inhibitors which can directly change the intracellular levels of H2O2 and O2 -.	Oxygen	196-198	superoxide dismutase 1	Homo sapiens	124-128
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	245-247	superoxide dismutase 1	Homo sapiens	42-46
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	245-247	superoxide dismutase 1	Homo sapiens	73-77
27284109-7	2016	To gain mechanistic insight into the increased fat oxidation in HFD-fed AdSod2 KO mice, we quantified the mitochondrial function and mitochondrial content in WAT and found that MnSOD deletion increased mitochondrial oxygen consumption and induced mitochondrial biogenesis.	Oxygen	216-222	superoxide dismutase 2, mitochondrial	Mus musculus	177-182
30034766-5	2016	These inhibitors inactivate intracellular SOD1 via localization into the SOD1 active site, thereby coordinating to the Cu2+ in the active site of SOD1, blocking the access of O2 - to Cu2+, and breaking the Cu2+/Cu+ catalytic cycle essential for O2 - dismutation.	Oxygen	245-247	superoxide dismutase 1	Homo sapiens	73-77
27472253-15	2016	This was independently associated with an imbalance between oxygen transport and consumption and was corrected by insulin.	Oxygen	60-66	insulin	Homo sapiens	114-121
27491637-1	2016	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a master regulator of oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
27491637-1	2016	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a master regulator of oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
26851891-2	2016	We have previously reported that low oxygen-mediated activity of FGF2 leads to an increase in cellular lifespan and acquisition of regeneration competence in human dermal fibroblasts (iRC cells).	Oxygen	37-43	fibroblast growth factor 2	Homo sapiens	65-69
27556627-12	2016	CONCLUSION: The regional oxygen saturation index may be a simple and fast criterion for detecting vascular problems following free flap reconstruction compared with existing criteria.	Oxygen	25-31	arachidonate 5-lipoxygenase activating protein	Homo sapiens	131-135
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	38-44	mechanistic target of rapamycin kinase	Homo sapiens	157-161
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	64-70	mechanistic target of rapamycin kinase	Homo sapiens	157-161
27692362-2	2016	Transcription factors involved in gene regulation under low oxygen tension are the hypoxia-inducible factors, mainly HIF1A, EPAS1 and their dimerization partner HIF1B.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-122
27692362-12	2016	Interestingly, HIF1A, but not EPAS1, was detected in the nuclei of undifferentiated cytotrophoblasts, and in the nuclei of cytotrophoblasts that grew under 21% O2.	Oxygen	160-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-20
26825530-6	2016	When isolated from diabetic mice and cultured in high glucose, Drp1-null podocytes had more elongated mitochondria and better mitochondrial fitness associated with enhanced oxygen consumption and ATP production than wild-type podocytes.	Oxygen	173-179	dynamin 1-like	Mus musculus	63-67
26680008-7	2016	In conclusion, our data show that a non-lethal and transient ER stress triggers a rapid activation of JNK without inducing apoptosis, leading to the fragmentation of the mitochondrial network and a reduction of O2 ( -) production.	Oxygen	211-213	mitogen-activated protein kinase 8	Homo sapiens	102-105
27506747-10	2016	More interestingly, higher levels of circulating GRP78 protein were found in obese compared to lean subjects which correlated negatively with maximum oxygen uptake (VO2 Max) but positively with high-sensitivity C-reactive protein (hsCRP) and obesity indicators such as BMI, percentage body fat (PBF) and waist circumference.	Oxygen	150-156	heat shock protein family A (Hsp70) member 5	Homo sapiens	49-54
27655733-2	2016	The oxygen labile alpha subunits, HIF-1alpha/-2alpha, form a heterodimeric transcription factor with HIF-1beta and modulate gene expression.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-52
27597764-2	2016	We hypothesized that a nocturnal decrease of arterial oxygen saturation (SaO2) causes a temporary rise of [Epo] not detected by morning measurements.	Oxygen	54-60	erythropoietin	Homo sapiens	107-110
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Oxygen	355-357	cystathionine beta synthase	Rattus norvegicus	122-149
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Oxygen	355-357	cystathionine beta synthase	Rattus norvegicus	151-154
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Oxygen	384-386	cystathionine beta synthase	Rattus norvegicus	122-149
27238370-2	2016	We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate (HR) before and after blocking of enzyme Cystathionine beta-synthase (CBS) producing H2S in neural tissue by microinjection of aminooxyacetate (inhibitor of CBS) into the fourth ventricle of Wistar normotensive rats (WNR) and SHR followed by 30min of normoxia (21% inspired O2) or hypoxia (10% inspired O2) exposure.	Oxygen	384-386	cystathionine beta synthase	Rattus norvegicus	151-154
27325674-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) (also known as EGLN1) is a key oxygen sensor in mammals that posttranslationally modifies hypoxia-inducible factor alpha (HIF-alpha) and targets it for degradation.	Oxygen	74-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
27325674-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) (also known as EGLN1) is a key oxygen sensor in mammals that posttranslationally modifies hypoxia-inducible factor alpha (HIF-alpha) and targets it for degradation.	Oxygen	74-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
27325674-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) (also known as EGLN1) is a key oxygen sensor in mammals that posttranslationally modifies hypoxia-inducible factor alpha (HIF-alpha) and targets it for degradation.	Oxygen	74-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	58-63
27316461-0	2016	The Ca2+/Mn2+-transporting SPCA2 pump is regulated by oxygen and cell density in colon cancer cells.	Oxygen	54-60	ATPase secretory pathway Ca2+ transporting 2	Homo sapiens	27-32
27559166-5	2016	In a mouse model of oxygen-induced retinopathy, mimicking proliferative DR, p75(NTR)-dependent inflammation leads to ischemia and pathological angiogenesis through Semaphorin 3A.	Oxygen	20-26	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	76-84
27529549-0	2016	Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways.	Oxygen	11-17	mitogen-activated protein kinase 14	Homo sapiens	139-153
27563096-4	2016	We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1.	Oxygen	49-55	AKT serine/threonine kinase 1	Homo sapiens	14-17
27563096-4	2016	We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1.	Oxygen	49-55	egl-9 family hypoxia inducible factor 1	Homo sapiens	78-83
27563096-6	2016	In cells lacking oxygen or functional pVHL, Akt was activated to promote cell survival and tumorigenesis.	Oxygen	17-23	AKT serine/threonine kinase 1	Homo sapiens	44-47
27316461-3	2016	We found that in contrast with other Ca(2+)-ATPase isoforms the expression of SPCA2 was up-regulated under hypoxia (3% O2), in both adherent (2D) and spheroid (3D) cultures.	Oxygen	119-121	ATPase secretory pathway Ca2+ transporting 2	Homo sapiens	78-83
27316461-4	2016	In spheroids, experiencing lowest O2 levels (30-50 muM, measured by phosphorescence lifetime imaging microscopy), we observed lower staining with reactive oxygen species (ROS)-specific fluorescent probe, which correlated with increased SPCA2.	Oxygen	34-36	latexin	Homo sapiens	51-54
27107233-6	2016	The eminent performance of HMO@GO was attributed to its specific structure, that is, the abundant oxygen-containing groups on GO mediated the growth of highly dispersed HMO that preferably sequestrated Pb(II) through specific interaction, and the host GO offered the preconcentration of Pb(II) for enhanced sequestration through the Donnan membrane effect.	Oxygen	98-104	submaxillary gland androgen regulated protein 3B	Homo sapiens	202-208
27107233-6	2016	The eminent performance of HMO@GO was attributed to its specific structure, that is, the abundant oxygen-containing groups on GO mediated the growth of highly dispersed HMO that preferably sequestrated Pb(II) through specific interaction, and the host GO offered the preconcentration of Pb(II) for enhanced sequestration through the Donnan membrane effect.	Oxygen	98-104	submaxillary gland androgen regulated protein 3B	Homo sapiens	287-293
27563535-10	2015	CART was also associated with significant increase in peak oxygen uptake and maximal workload compared to the SG (p &lt; 0.05).	Oxygen	59-65	CART prepropeptide	Homo sapiens	0-4
27508526-0	2016	FY17-PDH-EVTest04 GodInput Impact of the Oxygen Defects1 FY17-PDH-EVTest04 Reduction Rates of Stearic AcidFY17-PDH-T04.	Oxygen	41-47	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	5-8
27508526-0	2016	FY17-PDH-EVTest04 GodInput Impact of the Oxygen Defects1 FY17-PDH-EVTest04 Reduction Rates of Stearic AcidFY17-PDH-T04.	Oxygen	41-47	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	62-65
27508526-0	2016	FY17-PDH-EVTest04 GodInput Impact of the Oxygen Defects1 FY17-PDH-EVTest04 Reduction Rates of Stearic AcidFY17-PDH-T04.	Oxygen	41-47	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	62-65
27377137-6	2016	The plasma IL-6 response to exercise (reported as fold changes) was significantly greater in HIGH (2.70 +- 1.51) than LOW (1.40 +- 0.32) (P = 0.04) and was also positively correlated to the mean exercise oxygen uptake (r = 0.54, P &lt; 0.01).	Oxygen	204-210	interleukin 6	Homo sapiens	11-15
27264439-1	2016	Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Abeta) induced reactive oxygen species production in the context of Alzheimer"s disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-beta peptide itself.	Oxygen	100-106	amyloid beta precursor protein	Homo sapiens	76-81
29964739-6	2016	When the dissolved oxygen was controlled between 1 to 2 mg L-1, the nitrite accumulation rate could be maintained around 90%, ensuring the stable operation of the subsequent anaerobic ammonia oxidation system.	Oxygen	19-25	immunoglobulin kappa variable 1-16	Homo sapiens	59-62
29964739-7	2016	The nitrogen of municipal wastewater could be stable and efficiently removed by the shortcut nitrification -ANAMMOX integration ABR with temperature of 30C and dissolved oxygen of 1-2 mg L-1.	Oxygen	170-176	immunoglobulin kappa variable 1-16	Homo sapiens	187-190
27335075-8	2016	SDF2 expression, however, was significantly diminished in placentas from neonates small for gestational age and in hypoxic in vitro conditions (P &lt;= 0.001, 2% O2), suggesting a link with cellular stress.	Oxygen	162-164	stromal cell derived factor 2	Homo sapiens	0-4
27131779-0	2016	Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.	Oxygen	142-148	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
27131779-0	2016	Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.	Oxygen	142-148	sirtuin 1	Rattus norvegicus	79-84
27131779-1	2016	Sirtuin 1 (Sirt1) is a class III histone deacetylase involved in neuroprotection induced by hyperbaric oxygen preconditioning (HBO-PC) in animal models of ischemia.	Oxygen	103-109	sirtuin 1	Rattus norvegicus	0-9
27131779-1	2016	Sirtuin 1 (Sirt1) is a class III histone deacetylase involved in neuroprotection induced by hyperbaric oxygen preconditioning (HBO-PC) in animal models of ischemia.	Oxygen	103-109	sirtuin 1	Rattus norvegicus	11-16
27155083-0	2016	Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis.	Oxygen	14-20	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	122-125
27345715-7	2016	Our results strongly suggest that the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.	Oxygen	172-178	arginyltransferase 1	Mus musculus	54-58
27345715-7	2016	Our results strongly suggest that the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.	Oxygen	172-178	regulator of G-protein signaling 4	Mus musculus	133-137
26765586-10	2016	High final CAT score was inversely related to oxygen therapy use (p = 0.001) and HTP prescription (p &lt; 0.001), and positively related to presence of co-morbidities (p = 0.001) and baseline CAT (p &lt; 0.001).	Oxygen	46-52	catalase	Homo sapiens	11-14
27409140-4	2016	Both CuL and CuL2 were redox-silent in the presence of ascorbate, but a CuL(NIm) complex can generate reactive oxygen species.	Oxygen	111-117	cullin 2	Homo sapiens	13-17
27294328-7	2016	RESULTS: Independent of intensity, PTH concentrations decreased with the onset of exercise (-21% to -33%; P &lt;= .001), increased thereafter, and were higher than baseline by the end of exercise at 75% maximal oxygen consumption (+52%; P &lt;= .001).	Oxygen	211-217	parathyroid hormone	Homo sapiens	35-38
26940531-12	2016	Two atypical mitochondrial electron transport chain subunits (Ndufa4l2 and Cox4i2) were among the most specifically expressed genes in CB glomus cells, highlighting their potential roles in mitochondria-mediated oxygen sensing.	Oxygen	212-218	Ndufa4, mitochondrial complex associated like 2	Mus musculus	62-70
27158936-5	2016	In addition, a significant increase in reactive oxygen species production, Nrf2 and NFkappaB activation in endothelial cells exposed to mutant SOD1 astrocytes in both human and murine BBB models were observed.	Oxygen	48-54	superoxide dismutase 1	Homo sapiens	143-147
26156288-2	2016	Erythropoietin (EPO) has been reported to have neuroprotective effects through anti-oxidative, anti-apoptotic, and anti-inflammatory mechanisms, and it has also been shown to modulate autophagy signaling in an oxygen toxicity model.	Oxygen	210-216	erythropoietin	Homo sapiens	0-14
26694499-0	2016	Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans.	Oxygen	62-68	erythropoietin	Homo sapiens	44-58
26694499-2	2016	Comparative effects of aerobic training and erythropoietin on oxygen uptake in untrained humans.	Oxygen	62-68	erythropoietin	Homo sapiens	44-58
26156288-2	2016	Erythropoietin (EPO) has been reported to have neuroprotective effects through anti-oxidative, anti-apoptotic, and anti-inflammatory mechanisms, and it has also been shown to modulate autophagy signaling in an oxygen toxicity model.	Oxygen	210-216	erythropoietin	Homo sapiens	16-19
26827127-9	2016	The catalase and MnSOD contents were also increased in myoblasts and myotubes that were maintained in 20% O2 compared with myoblasts and myotubes grown in 6% O2.	Oxygen	106-108	catalase	Mus musculus	4-12
27017351-7	2016	Pyranyl ring oxygen in compound 9a forms two hydrogen bonds with HIS353 and HIS513 residues in the active site of the ACE having good G score ([Formula: see text]) of this compound, comparable to that of the reference drug captopril ([Formula: see text]).	Oxygen	13-19	angiotensin I converting enzyme	Homo sapiens	118-121
27651777-0	2016	Protective mechanisms of microRNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons.	Oxygen	46-52	microRNA 27a	Homo sapiens	25-37
27139518-2	2016	At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-70
26827127-9	2016	The catalase and MnSOD contents were also increased in myoblasts and myotubes that were maintained in 20% O2 compared with myoblasts and myotubes grown in 6% O2.	Oxygen	106-108	superoxide dismutase 2, mitochondrial	Mus musculus	17-22
26827127-9	2016	The catalase and MnSOD contents were also increased in myoblasts and myotubes that were maintained in 20% O2 compared with myoblasts and myotubes grown in 6% O2.	Oxygen	158-160	catalase	Mus musculus	4-12
26827127-9	2016	The catalase and MnSOD contents were also increased in myoblasts and myotubes that were maintained in 20% O2 compared with myoblasts and myotubes grown in 6% O2.	Oxygen	158-160	superoxide dismutase 2, mitochondrial	Mus musculus	17-22
27217104-4	2016	Here, our bioinformatics analysis reveals other transcription factors, photoreceptors, kinases, and oxygen sensors that harbor a B12-binding domain that could also regulate activity in response to light absorption.	Oxygen	100-106	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	129-132
27478033-4	2016	Although hypoxia inducible factor - 1alpha was activated at 2% oxygen tension, increased extracellular matrix synthesis was not observed.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-42
27208107-3	2016	Nitrogen and oxygen isotope ratios of nitrite (delta(15)NNO2- and delta(18)ONO2-, respectively) are geochemical tracers for evaluating the sources and the in situ rate of nitrite turnover determined from the activities of nitrification and denitrification; however, the isotope ratios of nitrite from archaeal ammonia oxidation have been characterized only for a few marine species.	Oxygen	13-19	membrane frizzled-related protein	Homo sapiens	56-60
27536462-9	2016	A host of other biological systems are also altered in RLS, including the dopaminergic, oxygen-sensing, opioid, glutamatergic, and serotonergic systems.	Oxygen	88-94	RLS1	Homo sapiens	55-58
28955916-0	2016	Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity.	Oxygen	77-83	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	141-146
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Oxygen	89-95	superoxide dismutase 2, mitochondrial	Mus musculus	18-23
27440994-9	2016	CONCLUSIONS: Collectively, our data show that expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF.	Oxygen	105-111	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	281-285
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
27312695-5	2016	The H-bond in the dioxygen adducts of the Co(II) porphyrins was directly measured by Q-band Davies-ENDOR spectroscopy.	Oxygen	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
27417117-1	2016	Depletion of mitochondrial endo/exonuclease G-like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS).	Oxygen	119-125	exo/endonuclease G	Homo sapiens	27-50
27191352-4	2016	Using small hydrogel bricks with oxygen distribution equal to the microchanneled configuration, this study demonstrates that among different culture conditions, co-culture of mesenchymal and endothelial cells supplemented with ANG-1 and VEGF leads to the most developed vascular network.	Oxygen	33-39	vascular endothelial growth factor A	Homo sapiens	237-241
27417117-1	2016	Depletion of mitochondrial endo/exonuclease G-like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS).	Oxygen	119-125	exo/endonuclease G	Homo sapiens	52-56
26997358-0	2016	Low oxygen tension favored expansion and hematopoietic reconstitution of CD34(+) CD38(-) cells expanded from human cord blood-derived CD34(+) Cells.	Oxygen	4-10	CD34 molecule	Homo sapiens	73-77
27540529-1	2016	OBJECTIVE: Hypoxia-Inducible Factor (HIF)-1 plays an essential role in the body"s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-43
26997358-0	2016	Low oxygen tension favored expansion and hematopoietic reconstitution of CD34(+) CD38(-) cells expanded from human cord blood-derived CD34(+) Cells.	Oxygen	4-10	CD34 molecule	Homo sapiens	134-138
26997358-6	2016	It was found that low oxygen tension favored expansion of CD34(+) CD38(-) cells.	Oxygen	22-28	CD34 molecule	Homo sapiens	58-62
26997358-7	2016	Additionally, CD34(+) cells expanded under low oxygen tension showed better secondary expansion ability and reconstitution ability than those under atmospheric oxygen concentration.	Oxygen	47-53	CD34 molecule	Homo sapiens	14-18
26997358-7	2016	Additionally, CD34(+) cells expanded under low oxygen tension showed better secondary expansion ability and reconstitution ability than those under atmospheric oxygen concentration.	Oxygen	160-166	CD34 molecule	Homo sapiens	14-18
26997358-8	2016	Finally, the genetic profiling of CD34(+) CD38(-) cells cultured under low oxygen tension was more akin to freshly isolated cells.	Oxygen	75-81	CD34 molecule	Homo sapiens	34-38
27039902-8	2016	In isolated mouse islets and MIN6 cells, O2 deprivation (1-5% vs 20%; 4-24 h) markedly reduced the expression of adaptive UPR genes, including Hspa5, Hsp90b1, Fkbp11 and spliced Xbp1.	Oxygen	41-43	heat shock protein 5	Mus musculus	143-148
27371670-4	2016	Similarly, during oxygen stress, p53 facilitates redirection of cellular metabolism toward energy generation through nonoxidative means, the suppression of reactive oxygen species (ROS) generation, and ROS detoxification-promoting cell survival.	Oxygen	18-24	tumor protein p53	Homo sapiens	33-36
27039902-8	2016	In isolated mouse islets and MIN6 cells, O2 deprivation (1-5% vs 20%; 4-24 h) markedly reduced the expression of adaptive UPR genes, including Hspa5, Hsp90b1, Fkbp11 and spliced Xbp1.	Oxygen	41-43	FK506 binding protein 11	Mus musculus	159-165
27039902-8	2016	In isolated mouse islets and MIN6 cells, O2 deprivation (1-5% vs 20%; 4-24 h) markedly reduced the expression of adaptive UPR genes, including Hspa5, Hsp90b1, Fkbp11 and spliced Xbp1.	Oxygen	41-43	X-box binding protein 1	Mus musculus	178-182
27026547-1	2016	Sediment oxygen demand (SOD) is a critical dissolved oxygen (DO) sink in many rivers.	Oxygen	9-15	superoxide dismutase 1	Homo sapiens	24-27
27026547-1	2016	Sediment oxygen demand (SOD) is a critical dissolved oxygen (DO) sink in many rivers.	Oxygen	53-59	superoxide dismutase 1	Homo sapiens	24-27
26204846-10	2016	In multivariate assessments performed for apnea/hypopnea index values, mean saturation O2 levels were found to be significantly associated with osteocalcin levels and neck BMD.	Oxygen	87-89	bone gamma-carboxyglutamate protein	Homo sapiens	144-155
27126377-5	2016	Moreover, estimated plasma volume excess rate was positively associated with EPO level (P = 0.003), and anaemic patients with a higher than expected EPO level tended to have a higher estimated plasma volume excess rate and plasma lactate level, and lower systemic oxygen saturation level with the preservation of the reticulocyte production index than those with a lower than expected EPO level.	Oxygen	264-270	erythropoietin	Homo sapiens	149-152
27126377-5	2016	Moreover, estimated plasma volume excess rate was positively associated with EPO level (P = 0.003), and anaemic patients with a higher than expected EPO level tended to have a higher estimated plasma volume excess rate and plasma lactate level, and lower systemic oxygen saturation level with the preservation of the reticulocyte production index than those with a lower than expected EPO level.	Oxygen	264-270	erythropoietin	Homo sapiens	149-152
27129925-3	2016	The reduction of molecular oxygen induced by the cytosolic NADH/cyto-c pathway is coupled to the generation of an electrochemical proton gradient available for ATP synthesis.	Oxygen	27-33	cytochrome c, somatic	Homo sapiens	64-70
27007876-11	2016	Compared with gene expression levels at 5 % O2, which were arbitrarily set as "1," 20 % O2 is associated with significantly higher expression of BAX (2.14 +- 0.47), G6PD (2.92 +- 1.06), MnSOD (2.87 +- 0.88), and HSP70.1 (8.68 +- 4.19).	Oxygen	88-90	heat shock protein family A (Hsp70) member 1A	Homo sapiens	212-219
27328274-8	2016	Paired t-tests matching variables measured at each stage of the GXT identified significantly higher values on the NMT for V[Combining Dot Above]O2 83% of the time, HR 67% of the time, and RPE 25% of the time.	Oxygen	144-146	N-myristoyltransferase 1	Homo sapiens	114-117
27499573-7	2016	Using multivariate analysis, pre-astaxanthin vascular endothelial growth factor level was associated with two factors of total hydroperoxide and O2 ( -) scavenging activity (r = 0.49, p&lt;0.05), and post-astaxanthin vascular endothelial growth factor level with two factors of total hydroperoxide and sex (r = 0.60, p&lt;0.01).	Oxygen	145-147	vascular endothelial growth factor A	Homo sapiens	45-79
27499573-8	2016	Astaxanthin intake may have affected vascular endothelial growth factor level through its antioxidant effects by increasing O2 ( -) scavenging activity and suppressing peroxide production.	Oxygen	124-126	vascular endothelial growth factor A	Homo sapiens	37-71
27087120-10	2016	We hypothesize that SUMOylated HIF-1alpha plays a fundamental role in the protection afforded and may underlie some of quercetin"s ability to protect cells from oxygen/glucose deprivation-induced cell death, via an up-regulation of HO-1 and NOS1, which ultimately leads to the induction of pro-life NOS1/protein kinase G signaling.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
26969105-17	2016	The effects of vasopressin on muHBO2 might be related to decreased oxygen consumption during hypercapnia.	Oxygen	67-73	arginine vasopressin	Rattus norvegicus	15-26
27340022-3	2016	mTOR integrates a variety of cues, such as growth factor levels, oxygen levels, and nutrient and energy availability, to regulate protein synthesis and cell growth.	Oxygen	65-71	mechanistic target of rapamycin kinase	Homo sapiens	0-4
27214402-5	2016	NSUN3-knockout cells showed strong reduction in mitochondrial protein synthesis and reduced oxygen consumption, leading to deficient mitochondrial activity.	Oxygen	92-98	NOP2/Sun RNA methyltransferase 3	Homo sapiens	0-5
28763176-0	2016	Patient diagnosed with chronic erectile dysfunction refractory to PDE 5 Inhibitor therapy reports improvement in function after hyperbaric oxygen therapy.	Oxygen	139-145	phosphodiesterase 5A	Homo sapiens	66-71
27260108-1	2016	Despite being prohibited by the World Anti-Doping Agency, blood doping through erythropoietin injection or blood transfusion is frequently used by athletes to increase oxygen delivery to muscles and enhance performance.	Oxygen	168-174	erythropoietin	Homo sapiens	79-93
26434586-5	2016	Furthermore, nestin was co-localized with mitochondria, and knockdown of nestin increased mitochondrial elongation and influenced the mitochondrial function, including oxygen consumption rates, ATP generation and mitochondrial membrane potential and so on.	Oxygen	168-174	nestin	Homo sapiens	13-19
27368101-6	2016	Therefore, EglN1 senses both oxygen and cysteine.	Oxygen	29-35	egl-9 family hypoxia inducible factor 1	Homo sapiens	11-16
26996298-0	2016	Leptin contributes to long-term stabilization of HIF-1alpha in cancer cells subjected to oxygen limiting conditions.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
27303039-5	2016	The results of the present study suggest a second source of (1)O2 formation in grana margins close to the site of chlorophyll synthesis where EX1 is localized and the disassembly of damaged and reassembly of active PSII take place.	Oxygen	60-65	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	142-145
27191981-1	2016	Hypoxia is a prominent feature of the microenvironment of solid tumors and may contribute to tumor progression through the oxygen-sensitive transcriptional regulator hypoxia-inducible factor-1 (HIF-1).	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-192
27191981-1	2016	Hypoxia is a prominent feature of the microenvironment of solid tumors and may contribute to tumor progression through the oxygen-sensitive transcriptional regulator hypoxia-inducible factor-1 (HIF-1).	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-199
27251591-5	2016	All complexes were, furthermore, employed in three benchmark oxygen-atom-transfer (OAT) reactions, namely, the reduction of perchlorate, the epoxidation of cyclooctene, and OAT from dimethyl sulfoxide (DMSO) to triphenylphosphane (PPh3), to assess the influence of the isomeric structure on the reactivity in these reactions.	Oxygen	61-67	caveolin 1	Homo sapiens	231-235
26434586-5	2016	Furthermore, nestin was co-localized with mitochondria, and knockdown of nestin increased mitochondrial elongation and influenced the mitochondrial function, including oxygen consumption rates, ATP generation and mitochondrial membrane potential and so on.	Oxygen	168-174	nestin	Homo sapiens	73-79
27297177-3	2016	We demonstrate that orthologues of Nrf2 first appeared in fungi around 1.5 Ga during the Paleoproterozoic when photosynthetic oxygen was being absorbed into the oceans.	Oxygen	126-132	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
27378854-1	2016	The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy, stress, oxygen levels, and growth factors.	Oxygen	96-102	mechanistic target of rapamycin kinase	Homo sapiens	11-40
27378854-1	2016	The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy, stress, oxygen levels, and growth factors.	Oxygen	96-102	mechanistic target of rapamycin kinase	Homo sapiens	42-46
26819450-12	2016	Inactivation of HIF1/NDUFA4L2 increased mitochondrial activity and oxygen consumption, resulting in ROS accumulation and apoptosis.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-20
27247382-4	2016	Here, we use live-cell imaging to demonstrate that OPTN, NDP52, and TAX1BP1 are recruited to mitochondria with similar kinetics following either mitochondrial depolarization or localized generation of reactive oxygen species, leading to sequestration by the autophagosome within ~45 min after insult.	Oxygen	210-216	optineurin	Homo sapiens	51-55
27297177-4	2016	A subsequent significant divergence in Nrf2 is seen during the split between fungi and the Metazoa approximately 1.0-1.2 Ga, at a time when oceanic ventilation released free oxygen to the atmosphere, but with most being absorbed by methane oxidation and oxidative weathering of land surfaces until approximately 800 Ma.	Oxygen	174-180	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
27159266-9	2016	Addition of 7 mL min(-1) O2 to the Ar plasma discharge resulted in a quantitative retention of arsane in the optical arm of the DBD atomizer.	Oxygen	25-27	CD59 molecule (CD59 blood group)	Homo sapiens	17-23
27295076-8	2016	CNI-induced TLR4 activity increased O2(-)/ROS production and NF-kappaB-regulated synthesis of proinflammatory factors in cultured as well as aortic endothelial and VSMCs.	Oxygen	36-38	toll-like receptor 4	Mus musculus	12-16
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
27277809-5	2016	Nrf2 activation by DMF but not MMF was associated with depletion of glutathione, decreased cell viability, and inhibition of mitochondrial oxygen consumption and glycolysis rates in a dose-dependent manner, whereas MMF increased these activities in vitro However, both DMF and MMF upregulated mitochondrial biogenesis in vitro in an Nrf2-dependent manner.	Oxygen	139-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
27114304-7	2016	Depletion of Sirt3 suppressed glutamate dehydrogenase activity, leading to impaired mitochondrial oxygen consumption.	Oxygen	98-104	sirtuin 3	Homo sapiens	13-18
27283141-8	2016	CONCLUSIONS: The new facts support the hypothesis that carotenoids that show anticancer effects with anti-oxygen function might reduce the risk of ER- breast cancer.	Oxygen	106-112	estrogen receptor 1	Homo sapiens	147-149
27058876-6	2016	HIF-1alpha signaling limits oxygen consumption to avoid accumulation of harmful ROS and preserve redox balance, and additionally induces a switch to glycolysis to prevent energetic distress.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
27208681-6	2016	A combination of any two of: P(a)o(2) &lt;= 10.5 kPa, FEV(1) &lt;= 60% predicted, and PEF &lt;= 350 L   min(-1) predicted the need for in-flight oxygen with a sensitivity of 89% and a specificity of 69%.	Oxygen	145-151	CD59 molecule (CD59 blood group)	Homo sapiens	104-110
26826591-7	2016	When O(2) leaves the active site, a second Ca-bound water molecule reorients to bridge the gap between the manganese ions Mn1 and Mn4, forming a new oxo-bridge for the next reaction cycle.	Oxygen	5-9	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	122-125
26841878-2	2016	The mice were exposed to 75 % oxygen from P7 to P12 to initiate oxygen-induced retinopathy (OIR).	Oxygen	64-70	polymerase (DNA-directed), delta 4	Mus musculus	48-51
27055905-10	2016	The importance of IL-17A in oxygen-induced retinopathy was confirmed by IL-17A neutralization reducing vasculopathy, VEGF, placental growth factor, tumor necrosis factor-alpha, microglial density and Muller cell, and ganglion cell injury.	Oxygen	28-34	tumor necrosis factor	Rattus norvegicus	148-175
26987588-0	2016	Silencing of S100A4, a metastasis-associated protein, inhibits retinal neovascularization via the downregulation of BDNF in oxygen-induced ischaemic retinopathy.	Oxygen	124-130	S100 calcium binding protein A4	Mus musculus	13-52
26901626-3	2016	In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a dioxygen generator under irradiation with LED light in water.	Oxygen	99-107	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	80-83
27032396-2	2016	On a molecular level, this response can be controlled by oxygen-dependent stabilization of the transcription factor hypoxia-inducible factor (HIF)-1alpha.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-153
27281270-3	2016	METHODS: Retinopathy was induced by exposing mice to 75% oxygen from postnatal day 7 (P7) to P12.	Oxygen	57-63	polymerase (DNA-directed), delta 4	Mus musculus	93-96
26777666-6	2016	We identified that the changing oxygen tension triggered mitochondrial uncoupling protein 2 (UCP2) expression and showed that UCP2 is crucial for these adaptive mitochondrial responses.	Oxygen	32-38	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	57-91
27108485-0	2016	TLR2/NFkappaB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.	Oxygen	156-162	toll-like receptor 2	Rattus norvegicus	0-4
27108485-0	2016	TLR2/NFkappaB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.	Oxygen	156-162	interleukin 6	Rattus norvegicus	46-50
27108485-1	2016	Two previous studies published by our group identified that mesenchymal stromal cells (MSCs) conferred neuroprotection in a rat model of hypoxic-ischaemic brain damage (HIBD), and that MSCs secreted abundant interleukin-6 (IL-6) when co-cultured with oxygen and glucose deprivation (OGD)-injured PC12 cells.	Oxygen	251-257	interleukin 6	Rattus norvegicus	208-221
26777666-6	2016	We identified that the changing oxygen tension triggered mitochondrial uncoupling protein 2 (UCP2) expression and showed that UCP2 is crucial for these adaptive mitochondrial responses.	Oxygen	32-38	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	93-97
26777666-6	2016	We identified that the changing oxygen tension triggered mitochondrial uncoupling protein 2 (UCP2) expression and showed that UCP2 is crucial for these adaptive mitochondrial responses.	Oxygen	32-38	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	126-130
26777666-7	2016	In UCP2 KO mice, changing oxygen tension did not induce changes in mitochondrial parameters and function but decreased mitochondria-ER contacts and resulted in loss of synapses both in the cortex and hippocampus.	Oxygen	26-32	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	3-7
27089028-7	2016	The roGFP2-Tsa2DeltaCR probe revealed real-time interplay between basal H2O2 levels and partial oxygen pressure.	Oxygen	96-102	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	11-15
27193867-0	2016	Oxygen diffusion in ThO2-CeO2 and ThO2-UO2 solid solutions from atomistic calculations.	Oxygen	0-6	THO complex 2	Homo sapiens	20-24
27193867-0	2016	Oxygen diffusion in ThO2-CeO2 and ThO2-UO2 solid solutions from atomistic calculations.	Oxygen	0-6	THO complex 2	Homo sapiens	34-38
27193867-1	2016	We elucidate oxygen diffusivity in ThO2-CeO2 and ThO2-UO2 solid solutions across their whole concentration ranges in the phase diagram using static pair-potential calculations and molecular dynamics simulations.	Oxygen	13-19	THO complex 2	Homo sapiens	35-39
27193867-1	2016	We elucidate oxygen diffusivity in ThO2-CeO2 and ThO2-UO2 solid solutions across their whole concentration ranges in the phase diagram using static pair-potential calculations and molecular dynamics simulations.	Oxygen	13-19	THO complex 2	Homo sapiens	49-53
27193867-2	2016	Between pure CeO2 (and UO2) and pure ThO2, oxygen diffusivity is higher in CeO2 (and UO2) due to lower oxygen migration barriers.	Oxygen	43-49	THO complex 2	Homo sapiens	37-41
27193867-2	2016	Between pure CeO2 (and UO2) and pure ThO2, oxygen diffusivity is higher in CeO2 (and UO2) due to lower oxygen migration barriers.	Oxygen	103-109	THO complex 2	Homo sapiens	37-41
27193867-4	2016	On the other side of the phase diagram, with the addition of Ce to ThO2 oxygen diffusion decreases due to oxygen vacancy binding with Ce, even though the migration barriers decrease due to the smaller size of Ce than the host Th.	Oxygen	72-78	THO complex 2	Homo sapiens	67-71
27211491-2	2016	Under ambient conditions, AgO has two nonequivalent Ag1 and Ag2 sites that adopt linear and square planar oxygen environment configuration, respectively, corresponding to Ag mixed-valence states.	Oxygen	106-112	NBPF member 10	Homo sapiens	52-55
27059084-5	2016	Furthermore, low oxygen increases canonical Wnt pathway signaling coreceptor Lrp5 expression, and PI3K/Akt pathway activation.	Oxygen	17-23	LDL receptor related protein 5	Homo sapiens	77-81
27059084-7	2016	Wortmannin-mediated PI3K/Akt pathway inhibition leads to increased osteoblastic differentiation at both low and high oxygen tension.	Oxygen	117-123	AKT serine/threonine kinase 1	Homo sapiens	25-28
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	interleukin 6	Mus musculus	90-103
27059084-8	2016	We demonstrate that low oxygen stimulates a complex signaling network involving PI3K/Akt, Notch, and canonical Wnt pathways, which mediate the observed increase in nuclear Oct4a and REST, with simultaneous decrease in p53, AIF, and Bak.	Oxygen	24-30	AKT serine/threonine kinase 1	Homo sapiens	85-88
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	interleukin 6	Mus musculus	105-109
27059084-8	2016	We demonstrate that low oxygen stimulates a complex signaling network involving PI3K/Akt, Notch, and canonical Wnt pathways, which mediate the observed increase in nuclear Oct4a and REST, with simultaneous decrease in p53, AIF, and Bak.	Oxygen	24-30	tumor protein p53	Homo sapiens	218-221
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	tumor necrosis factor	Mus musculus	112-139
27059084-10	2016	Importantly, the PI3K/Akt pathway plays a central mechanistic role in the oxygen tension-regulated self-renewal versus osteoblastic differentiation of progenitor cells.	Oxygen	74-80	AKT serine/threonine kinase 1	Homo sapiens	22-25
27303300-6	2016	However, the role of VIP family members in GBM infiltration under low oxygen tension has not been clarified yet.	Oxygen	70-76	vasoactive intestinal peptide	Homo sapiens	21-24
27496406-2	2016	Rising graft temperature during WIT2, which comprises the creation of vascular anastomoses, increases oxygen demand and tissue damage, especially in the kidney tubular cells.	Oxygen	102-108	WT1 transcription factor	Homo sapiens	32-36
27245613-1	2016	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that enable cells to adapt to reduced O2 availability.	Oxygen	128-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
27245613-1	2016	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that enable cells to adapt to reduced O2 availability.	Oxygen	128-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
27303300-8	2016	The results suggest that either PACAP or VIP exert an anti-infiltrative effect under low oxygen tension by modulating HIFs and EGFR expression, key elements involved in cell migration and angiogenesis.	Oxygen	89-95	vasoactive intestinal peptide	Homo sapiens	41-44
27239113-6	2016	RESULTS: HIF-1alpha is highly expressed in the esophageal carcinoma cell lines tested, and with decreasing levels of oxygen, the expression of HIF-1alpha and the associated glycolytic enzymes and the extracellular lactic acid concentration were enhanced in the esophageal carcinoma cell lines Eca109 and TE13.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
27210110-5	2016	HIF1alpha was higher in HAPE-S (320.3 +- 267.5 vs 58.75 +- 33.88 pg/ml, P &lt; 0.05) than HAPE-R, at baseline, despite no significant difference in baseline oxygen saturations (97.7 +- 1.7% and 98.8 +- 0.7).	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
27223464-2	2016	In normoxia, HIFalpha is hydroxylated by specific prolyl-4-hydroxylases, targeting it for proteasomal degradation, while in hypoxia the activity of these hydroxylases decreases due to low oxygen availability, leading to HIFalpha accumulation and expression of HIF target genes.	Oxygen	188-194	similar	Drosophila melanogaster	13-21
27223464-6	2016	Thus, miR-190 is a novel regulator of the hypoxia response that represses the oxygen sensor Fatiga, leading to HIFalpha stabilization and enhancement of hypoxic responses.	Oxygen	78-84	mir-190 stem loop	Drosophila melanogaster	6-13
27223464-6	2016	Thus, miR-190 is a novel regulator of the hypoxia response that represses the oxygen sensor Fatiga, leading to HIFalpha stabilization and enhancement of hypoxic responses.	Oxygen	78-84	HIF prolyl hydroxylase	Drosophila melanogaster	92-98
27223464-6	2016	Thus, miR-190 is a novel regulator of the hypoxia response that represses the oxygen sensor Fatiga, leading to HIFalpha stabilization and enhancement of hypoxic responses.	Oxygen	78-84	similar	Drosophila melanogaster	111-119
28539803-0	2016	Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy.	Oxygen	118-124	vascular endothelial growth factor A	Homo sapiens	5-9
27284569-2	2016	The AHR-dependent TCDD-induced mitochondrial hyperpolarization (Tappenden et al., 2011) [1] and reduced oxygen consumption rate of intact mouse hepatoma cells (Huang et al., in press) [2] in the previous studies suggest that these alterations can be related to enzymatic activities of the electron transport chain (ETC) and ATP synthase in oxidative phosphorylation (OXPHOS) system.	Oxygen	104-110	aryl-hydrocarbon receptor	Mus musculus	4-7
27083257-9	2016	Oxygen moieties in organic cations decreased the affinity for C18/SCX-SPME.	Oxygen	0-6	Bardet-Biedl syndrome 9	Homo sapiens	62-65
27198227-5	2016	Loss of GRSF1 lowered the mitochondrial levels of RMRP, in turn suppressing oxygen consumption rates and modestly reducing mitochondrial DNA replication priming.	Oxygen	76-82	G-rich RNA sequence binding factor 1	Homo sapiens	8-13
27058421-3	2016	Here we report that hypoxia (1% O2) treatment of PrECs, prostate cell lines, and a macrophage cell line (THP-1) increased the levels of NLRP3, AIM2, and pro-IL-1beta.	Oxygen	32-34	NLR family pyrin domain containing 3	Homo sapiens	136-141
27323011-2	2016	In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro.	Oxygen	68-74	microRNA 152	Rattus norvegicus	15-27
27323011-2	2016	In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro.	Oxygen	68-74	microRNA 152	Rattus norvegicus	29-36
27058421-3	2016	Here we report that hypoxia (1% O2) treatment of PrECs, prostate cell lines, and a macrophage cell line (THP-1) increased the levels of NLRP3, AIM2, and pro-IL-1beta.	Oxygen	32-34	absent in melanoma 2	Homo sapiens	143-147
27058421-3	2016	Here we report that hypoxia (1% O2) treatment of PrECs, prostate cell lines, and a macrophage cell line (THP-1) increased the levels of NLRP3, AIM2, and pro-IL-1beta.	Oxygen	32-34	interleukin 1 beta	Homo sapiens	153-165
27279905-4	2016	We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis.	Oxygen	153-159	microRNA 675	Homo sapiens	44-50
27073983-7	2016	The results indicate that the NO3 addition reactions on the aromatic ring of the methoxyphenols are exothermic, with energy values ranging between -13 and -21 kcal mol(-1), depending on the environment of the carbon on which the oxygen atom of NO3 is attached.	Oxygen	229-235	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
27073983-7	2016	The results indicate that the NO3 addition reactions on the aromatic ring of the methoxyphenols are exothermic, with energy values ranging between -13 and -21 kcal mol(-1), depending on the environment of the carbon on which the oxygen atom of NO3 is attached.	Oxygen	229-235	NBL1, DAN family BMP antagonist	Homo sapiens	244-247
27011264-5	2016	The slow reaction process on the single Co(III) -OH site of the Co3 O4 cocatalyst, oxidizing H2 O to H2 O2 with two photogenerated holes, could be accelerated by the timely H2 O2 oxidation to O2 catalyzed on CDots.	Oxygen	104-106	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	40-47
27094953-4	2016	Incorporation into a nanostructured metal-oxide matrix (AP200/19) gave highly sensitive O2 sensing films, as the detection sensitivity was 200-300% higher than with the commonly used PtTFPP and approaches the sensitivity of the best O2-sensing dyes reported to date.	Oxygen	88-90	adaptor related protein complex 1 subunit sigma 1	Homo sapiens	56-64
27094953-4	2016	Incorporation into a nanostructured metal-oxide matrix (AP200/19) gave highly sensitive O2 sensing films, as the detection sensitivity was 200-300% higher than with the commonly used PtTFPP and approaches the sensitivity of the best O2-sensing dyes reported to date.	Oxygen	233-235	adaptor related protein complex 1 subunit sigma 1	Homo sapiens	56-64
27117397-1	2016	The apparent four-electron oxygen evolution catalyzed by Co3O4 nanosheets indeed proceeds via a double two-electron process, because the generated Co(III)/Co(IV) redox couple can synchronously, quickly, and effectively oxidate the intermediate OOH(ads), and thus accelerate O generation.	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	147-154
26791377-1	2016	mTOR is a serine/threonine (Ser/Thr) protein kinase that responds to multiple signals, including growth factors, amino acids, energy status, stress, and oxygen, regulates cell survival, cell growth, the cell cycle, and cell metabolism, and maintains homeostasis [1].	Oxygen	153-159	mechanistic target of rapamycin kinase	Homo sapiens	0-4
27199656-3	2016	PGRN has a neurotrophic and anti-inflammatory activity, and it is neuroprotective in several injury conditions, such as oxygen or glucose deprivation, oxidative injury, and hypoxic stress.	Oxygen	120-126	granulin precursor	Homo sapiens	0-4
26082309-6	2016	Addition of a selective inhibitor of the oxygen-sensitive prolyl hydroxylase domain-containing protein 2 (PHD-2), IOX2, fully recovered HIF-1alpha stability, nuclear translocation, and target gene expression in NHEK and NHDF.	Oxygen	41-47	egl-9 family hypoxia inducible factor 1	Homo sapiens	58-104
26082309-6	2016	Addition of a selective inhibitor of the oxygen-sensitive prolyl hydroxylase domain-containing protein 2 (PHD-2), IOX2, fully recovered HIF-1alpha stability, nuclear translocation, and target gene expression in NHEK and NHDF.	Oxygen	41-47	egl-9 family hypoxia inducible factor 1	Homo sapiens	106-111
26082309-6	2016	Addition of a selective inhibitor of the oxygen-sensitive prolyl hydroxylase domain-containing protein 2 (PHD-2), IOX2, fully recovered HIF-1alpha stability, nuclear translocation, and target gene expression in NHEK and NHDF.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
27071377-2	2016	Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which hypoxia-inducible factor 1 (HIF-1), an oxygen-sensitive transcription factor that allows adaptation to hypoxia environments, has been shown to play an important function.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	241-267
27071377-2	2016	Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which hypoxia-inducible factor 1 (HIF-1), an oxygen-sensitive transcription factor that allows adaptation to hypoxia environments, has been shown to play an important function.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	269-274
27071377-2	2016	Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which hypoxia-inducible factor 1 (HIF-1), an oxygen-sensitive transcription factor that allows adaptation to hypoxia environments, has been shown to play an important function.	Oxygen	280-286	hypoxia inducible factor 1 subunit alpha	Homo sapiens	269-274
26856890-4	2016	Conversely, exposure to increased oxygen levels rescued NSC differentiation in Gpr124 null embryos and increased it further in WT embryos, suggesting that niche blood vessels regulate NSC differentiation at least in part by providing oxygen.	Oxygen	34-40	adhesion G protein-coupled receptor A2	Homo sapiens	79-85
26856890-4	2016	Conversely, exposure to increased oxygen levels rescued NSC differentiation in Gpr124 null embryos and increased it further in WT embryos, suggesting that niche blood vessels regulate NSC differentiation at least in part by providing oxygen.	Oxygen	234-240	adhesion G protein-coupled receptor A2	Homo sapiens	79-85
27001071-0	2016	Knockdown of Drosophila hemoglobin suggests a role in O2 homeostasis.	Oxygen	54-56	globin 1	Drosophila melanogaster	24-34
27001071-8	2016	However, the knockdown of glob1 led to a significantly reduced survival rate of adult flies under hypoxia (5% and 1.5% O2).	Oxygen	119-121	globin 1	Drosophila melanogaster	26-31
27001071-9	2016	Surprisingly, the glob1 knockdown flies also displayed increased resistance towards the reactive oxygen species-forming agent paraquat, which may be explained by a restricted availability of O2 resulting in decreased formation of harmful O2(-).	Oxygen	191-193	globin 1	Drosophila melanogaster	18-23
27001071-9	2016	Surprisingly, the glob1 knockdown flies also displayed increased resistance towards the reactive oxygen species-forming agent paraquat, which may be explained by a restricted availability of O2 resulting in decreased formation of harmful O2(-).	Oxygen	238-240	globin 1	Drosophila melanogaster	18-23
27001071-10	2016	In summary, our results suggest an important functional role of glob1 in O2 homeostasis, possibly by enhancing O2 supply.	Oxygen	73-75	globin 1	Drosophila melanogaster	64-69
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Oxygen	239-245	BCL2-related ovarian killer	Mus musculus	31-34
26708156-5	2016	RESULTS: BMP-2 is much more efficient to stimulate the expression of the cartilage-specific gene COL2A1 by HACs when cultured under hypoxia (1%O2) compared to normoxia (21%O2).	Oxygen	143-145	collagen type II alpha 1 chain	Homo sapiens	97-103
26708156-5	2016	RESULTS: BMP-2 is much more efficient to stimulate the expression of the cartilage-specific gene COL2A1 by HACs when cultured under hypoxia (1%O2) compared to normoxia (21%O2).	Oxygen	172-174	collagen type II alpha 1 chain	Homo sapiens	97-103
27800511-0	2016	Oxygen-dependent regulation of aquaporin-3 expression.	Oxygen	0-6	aquaporin 3	Mus musculus	31-42
26879839-4	2016	The primary endpoint of the study was the effect of epoetin alfa on peak oxygen uptake (VO2 max) at the cardiopulmonary exercise test.	Oxygen	73-79	erythropoietin	Homo sapiens	52-59
27010351-1	2016	The kinetics for the isomerization of the 50e cluster Os3(mu-TeTol-p)2(CO)10 (), where the tellurides bridge two different Os-Os edges, to one in which the tellurides bridge the same open OsOs edge () have been measured experimentally by (1)H NMR spectroscopy.	Oxygen	123-128	asporin	Homo sapiens	54-57
26867580-0	2016	Control of the Position of Oxygen Delivery in Soybean Lipoxygenase-1 by Amino Acid Side Chains within a Gas Migration Channel.	Oxygen	27-33	seed linoleate 13S-lipoxygenase-1	Glycine max	54-68
26867580-1	2016	Understanding gas migration pathways is critical to unraveling structure-function relationships in enzymes that process gaseous substrates such as O2, H2, and N2 This work investigates the role of a defined pathway for O2 in regulating the peroxidation of linoleic acid by soybean lipoxygenase 1.	Oxygen	219-221	seed linoleate 13S-lipoxygenase-1	Glycine max	281-295
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Oxygen	76-82	BCL2-related ovarian killer	Mus musculus	31-34
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Oxygen	76-82	BCL2-related ovarian killer	Mus musculus	183-186
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Oxygen	239-245	BCL2-related ovarian killer	Mus musculus	183-186
26612512-6	2016	IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O2) saturation &lt; 90% and positively correlated with the average and minimum O2 saturation (p = 0.027).	Oxygen	115-121	insulin like growth factor 1	Homo sapiens	0-5
26934203-0	2016	Catalase-Modified Carbon Electrodes: Persuading Oxygen To Accept Four Electrons Rather Than Two.	Oxygen	48-54	catalase	Homo sapiens	0-8
26934203-1	2016	We successfully exploited the natural highly efficient activity of an enzyme (catalase) together with carbon electrodes to produce a hybrid electrode for oxygen reduction, very appropriate for energy transformation.	Oxygen	154-160	catalase	Homo sapiens	78-86
26934203-3	2016	With the immobilization of catalase on the surface, the hydrogen peroxide produced electrochemically is decomposed back to oxygen by the enzyme; the enzyme natural activity on the surface regenerates oxygen, which is further reduced by the carbon electrode with no direct electron transfer between the enzyme and the electrode.	Oxygen	123-129	catalase	Homo sapiens	27-35
26934203-3	2016	With the immobilization of catalase on the surface, the hydrogen peroxide produced electrochemically is decomposed back to oxygen by the enzyme; the enzyme natural activity on the surface regenerates oxygen, which is further reduced by the carbon electrode with no direct electron transfer between the enzyme and the electrode.	Oxygen	200-206	catalase	Homo sapiens	27-35
26612512-6	2016	IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O2) saturation &lt; 90% and positively correlated with the average and minimum O2 saturation (p = 0.027).	Oxygen	123-125	insulin like growth factor 1	Homo sapiens	0-5
26612512-6	2016	IGF-1 level was negatively correlated with body mass index, waist circumference (WC), AHI, and sleep duration with oxygen (O2) saturation &lt; 90% and positively correlated with the average and minimum O2 saturation (p = 0.027).	Oxygen	202-204	insulin like growth factor 1	Homo sapiens	0-5
26612512-7	2016	In a multivariable linear regression, considering WC and minimum O2 saturation as independent variables, only the minimum O2 saturation was a predictor of low IGF-1 levels.	Oxygen	122-124	insulin like growth factor 1	Homo sapiens	159-164
26918937-5	2016	Our results strongly indicate that hydrogen abstraction from C13 in 15-LOX-2 is only consistent with the "tail-first" orientation of AA, with its carboxylate group interacting with Arg429, and that only the pro-S H13 hydrogen will be abstracted (being the pro-R H13 and H10 too far from the acceptor oxygen atom).	Oxygen	300-306	arachidonate 15-lipoxygenase	Homo sapiens	68-74
26935869-2	2016	The present study aimed to investigate the effects of miR-218, as well as its host genes, Slit2 and Slit3, on oxygen-induced retinal neovascularization (RNV) and to explore the associated mechanisms of action.	Oxygen	110-116	microRNA 218	Mus musculus	54-61
26971568-1	2016	Oxygen surface exchange kinetics and diffusion have been studied by the isotope exchange method with gas phase equilibration using a static circulation experimental rig in the temperature range of 600-800  C and oxygen pressure range of 0.13-2.5 kPa.	Oxygen	0-6	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	165-168
26857638-1	2016	BACKGROUND: We hypothesized that the myocardial oxygen supply-demand balance is impaired in patients after a Norwood procedure and that an abnormal oxygen supply-demand balance is associated with pronounced activation of the renin-angiotensin-aldosterone system and worse clinical outcome after this procedure.	Oxygen	148-154	renin	Homo sapiens	225-230
26857638-9	2016	CONCLUSIONS: Myocardial oxygen supply-demand imbalance is intrinsic to Norwood circulation but may be improved by technical refinement of aortic reconstruction or afterload-reducing medication with renin-angiotensin-aldosterone system blockade.	Oxygen	24-30	renin	Homo sapiens	198-203
26854136-10	2016	Levels of ROS, Bax, caspase-3 and BACE were increased, whereas expression of Bcl-2 was decreased, in cells treated with 95% oxygen plus 2.4% isoflurane compared with the control and 2.4% isoflurane plus air groups.	Oxygen	124-130	BCL2, apoptosis regulator	Rattus norvegicus	77-82
26593628-2	2016	The rate of ascorbate radical (Asc(-)) formation (and stability) was strongly dependent on the presence of oxygen.	Oxygen	107-113	PYD and CARD domain containing	Homo sapiens	12-37
27053772-4	2016	In human cortical neuronal cultures, excitotoxicity or ischemia due to oxygen and glucose deprivation led to cell death that was dependent on N-methyl-D-aspartate (NMDA) receptors, nitric oxide (NO), and poly(ADP-ribose) polymerase (PARP) (a cell death pathway called parthanatos that is distinct from apoptosis, necroptosis, and other forms of cell death).	Oxygen	71-77	poly(ADP-ribose) polymerase 1	Homo sapiens	204-231
27053772-4	2016	In human cortical neuronal cultures, excitotoxicity or ischemia due to oxygen and glucose deprivation led to cell death that was dependent on N-methyl-D-aspartate (NMDA) receptors, nitric oxide (NO), and poly(ADP-ribose) polymerase (PARP) (a cell death pathway called parthanatos that is distinct from apoptosis, necroptosis, and other forms of cell death).	Oxygen	71-77	poly(ADP-ribose) polymerase 1	Homo sapiens	233-237
27044404-7	2016	CONCLUSIONS: This review focusses on the importance of HIF-1 in the adaption and reprogramming of the metabolic system to reduced oxygen values as well as on the role of the tumor microenvironment for evasion of OSCC from immune recognition and destruction.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-60
26899267-0	2016	Melatonin and the von Hippel-Lindau/HIF-1 oxygen sensing mechanism: A review.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
30276274-4	2016	We also describe the neuroprotective influence of antioxidants, dichloroacetate, acetyl-L-carnitine, and combined therapy with ethanol and normobaric oxygen, explained in relation to PDH modulation.	Oxygen	150-156	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	183-186
26901092-6	2016	Furthermore, ColI(2.3)(+)/Rs1(+) mice showed reduced O2 consumption and respiratory quotient measures without effects on food intake and energy expenditure.	Oxygen	53-55	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	26-29
26405833-5	2016	In contrast, B/C mats formed at locations where oxygen in the water column was comparatively abundant (&gt;45 muM) and continuously present.	Oxygen	48-54	latexin	Homo sapiens	110-113
26935869-2	2016	The present study aimed to investigate the effects of miR-218, as well as its host genes, Slit2 and Slit3, on oxygen-induced retinal neovascularization (RNV) and to explore the associated mechanisms of action.	Oxygen	110-116	slit guidance ligand 2	Mus musculus	90-95
26972007-0	2016	The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.	Oxygen	4-10	egl-9 family hypoxia inducible factor 1	Homo sapiens	18-22
26375488-1	2016	Hypoxia-inducible factor-1alpha (HIF1a) is a key transcriptional regulator that enables cellular metabolic adaptation to low levels of oxygen.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26375488-1	2016	Hypoxia-inducible factor-1alpha (HIF1a) is a key transcriptional regulator that enables cellular metabolic adaptation to low levels of oxygen.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
26375488-7	2016	These findings suggest a possible role for the oxygen-dependent protein folding process from the ER-Golgi compartment in fine-tuning HIF1a transcriptional output.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-138
26403263-5	2016	Here we investigate the mechanism of a collagen I binding integrin alpha11 (ITGA11) deregulation in response to low oxygen-mediated FGF2 effects in dermal fibroblasts.	Oxygen	116-122	integrin subunit alpha 11	Homo sapiens	76-82
26403263-5	2016	Here we investigate the mechanism of a collagen I binding integrin alpha11 (ITGA11) deregulation in response to low oxygen-mediated FGF2 effects in dermal fibroblasts.	Oxygen	116-122	fibroblast growth factor 2	Homo sapiens	132-136
26096935-5	2016	The CYGB gene encodes cytoglobin, a member of the globin protein family, which facilitates the diffusion of oxygen through tissues and acts as a scavenger for nitric oxide or other ROS.	Oxygen	108-114	cytoglobin	Homo sapiens	4-8
26096935-5	2016	The CYGB gene encodes cytoglobin, a member of the globin protein family, which facilitates the diffusion of oxygen through tissues and acts as a scavenger for nitric oxide or other ROS.	Oxygen	108-114	cytoglobin	Homo sapiens	22-32
26846556-4	2016	Published calibrations for a common oxygen probe, Pd-porphyrin + bovine serum albumin (BSA), vary because of differences in the techniques used.	Oxygen	36-42	albumin	Homo sapiens	72-85
27016777-12	2016	CONCLUSION: During early placental development, SUMOylation events control HIF1A stability in an oxygen-dependent manner.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-80
27033381-6	2016	The short-lived reactive oxygen species (ROS) and reactive nitrogen species (RNS) are strongly coupled in liquid-phase reactions: NO3 is an important precursor for short-lived ROS, and in turn OH, O2(-) and HO2 play a crucial role for the production of short-lived RNS.	Oxygen	197-199	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
26883495-6	2016	X-ray photoelectron spectroscopy (XPS) and photoluminescence (PL) measurements confirm the presence of more oxygen defects in the TNF samples compared to the NW samples.	Oxygen	108-114	tumor necrosis factor	Homo sapiens	130-133
26972007-0	2016	The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.	Oxygen	4-10	filamin A	Homo sapiens	82-91
26960375-0	2016	microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1.	Oxygen	22-28	roundabout guidance receptor 1	Mus musculus	95-107
26930130-10	2016	This study provides further insight into the Cu(I) coordination properties of His111 in human PrP(C) and the molecular mechanism of oxygen activation by this site.	Oxygen	132-138	prion protein	Homo sapiens	94-100
26960375-4	2016	Our present work explored the expression and the role of microRNA-128 (miR-218) in oxygen-induced RNV.	Oxygen	83-89	microRNA 218	Mus musculus	71-78
26732686-5	2016	Insulin augmented heart rate, blood pressure, and stroke index in both groups (all P &lt; 0.01) and significantly increased myocardial oxygen consumption (P = 0.04) and perfusion (P = 0.01) in both groups.	Oxygen	135-141	insulin	Homo sapiens	0-7
27054191-2	2016	Herein we present data relative to the effect of knocking down BCKDK gene on the real time oxygen consumption rate of fibroblasts obtained from a Maple Syrup Urine Disease (MSUD) patient.	Oxygen	91-97	branched chain keto acid dehydrogenase kinase	Homo sapiens	63-68
26949978-7	2016	Mechanistic investigations of dioxygen reduction revealed that the reaction proceeds through a eta(2)-peroxo intermediate (Int1) at low temperatures followed by subsequent ligand oxidation at higher temperatures in a reaction that consumed half an equivalent of O2 and produced water as a final oxygenic byproduct.	Oxygen	30-38	Wnt family member 1	Homo sapiens	123-127
26949978-7	2016	Mechanistic investigations of dioxygen reduction revealed that the reaction proceeds through a eta(2)-peroxo intermediate (Int1) at low temperatures followed by subsequent ligand oxidation at higher temperatures in a reaction that consumed half an equivalent of O2 and produced water as a final oxygenic byproduct.	Oxygen	262-264	Wnt family member 1	Homo sapiens	123-127
26949978-9	2016	The reaction of 4-Me with dioxygen at low temperature produces a species (8-Me) analogous to Int1 demonstrating that initial dioxygen activation is an inner sphere Pd-based process where the hydroquinone moiety only subsequently participates in the reduction of O2, at higher temperatures, by H(+)/e(-) transfers.	Oxygen	26-34	Wnt family member 1	Homo sapiens	93-97
26949978-9	2016	The reaction of 4-Me with dioxygen at low temperature produces a species (8-Me) analogous to Int1 demonstrating that initial dioxygen activation is an inner sphere Pd-based process where the hydroquinone moiety only subsequently participates in the reduction of O2, at higher temperatures, by H(+)/e(-) transfers.	Oxygen	125-133	Wnt family member 1	Homo sapiens	93-97
26949978-9	2016	The reaction of 4-Me with dioxygen at low temperature produces a species (8-Me) analogous to Int1 demonstrating that initial dioxygen activation is an inner sphere Pd-based process where the hydroquinone moiety only subsequently participates in the reduction of O2, at higher temperatures, by H(+)/e(-) transfers.	Oxygen	262-264	Wnt family member 1	Homo sapiens	93-97
26861551-2	2016	Exploration of 8-oxoadenine derivatives bearing saturated oxygen or nitrogen heterocycles in the N-9 substituent has revealed a remarkable selective enhancement in IFNalpha inducing potency in the nitrogen series.	Oxygen	58-64	interferon alpha 1	Homo sapiens	164-172
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	198-204	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	198-204	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	198-204	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	198-204	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	198-204	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	125-127	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	125-127	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	125-127	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	125-127	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	125-127	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-5	2016	The AlO2(NO3)2(-) fragment also undergoes elimination of O2.	Oxygen	6-8	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Oxygen	18-20	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Oxygen	18-20	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Oxygen	4-10	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Oxygen	42-48	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Oxygen	42-48	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
26948053-1	2016	Unlike most cells, cancer cells activate hypoxia inducible factor-1 (HIF-1) to use glycolysis even at normal oxygen levels, or normoxia.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-67
27005664-1	2016	As Nuclear Factor-kappaB (NF-kappaB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability.	Oxygen	172-178	nuclear factor kappa B subunit 1	Homo sapiens	26-35
26962451-11	2016	Adaptations in PMN gene expression in OVE + SM cows associated with the lower SCC were gradual increases from -10 to 21 d in genes that facilitate migration into inflammatory sites (SELL, ITGAM), enzymes essential for reducing reactive oxygen metabolites (SOD1, SOD2), and a transcription factor(s) required for controlling PMN development (RXRA).	Oxygen	236-242	integrin subunit alpha M	Bos taurus	188-193
26948053-1	2016	Unlike most cells, cancer cells activate hypoxia inducible factor-1 (HIF-1) to use glycolysis even at normal oxygen levels, or normoxia.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
27512758-0	2016	WT1 in Cardiac Development and Disease The heart is essential for realizing the distribution of oxygen and nutrients throughout the body.	Oxygen	96-102	WT1 transcription factor	Homo sapiens	0-3
26838789-7	2016	Induction of O2 (-) production in H9C2 cardiac myocytes led to the release of a transferable factor able to induce peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ expression in cocultured EpAT.	Oxygen	13-15	adiponectin, C1Q and collagen domain containing	Homo sapiens	189-195
26936506-0	2016	Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.	Oxygen	25-31	activating transcription factor 4	Mus musculus	70-74
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Oxygen	13-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Oxygen	13-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
26741196-5	2016	We observed that 1) MA-10:TspoDelta/Delta cells had a shift in substrate utilization for energy production from glucose to fatty acids with significantly higher mitochondrial fatty acid oxidation (FAO), and increased reactive oxygen species production; and 2) oxygen consumption rate, mitochondrial membrane potential, and proton leak were not different between MA-10:TspoDelta/Delta and MA-10:Tspo+/+ control cells.	Oxygen	226-232	translocator protein	Mus musculus	26-30
27192835-2	2016	It has been found out that low concentrations of O2 and factor bFGF added to the cell culture medium increase an expression of abcg2 gene and its gene protein, ABCG2 transport gene, in mesenchymal stem cells.	Oxygen	49-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	127-132
27192835-2	2016	It has been found out that low concentrations of O2 and factor bFGF added to the cell culture medium increase an expression of abcg2 gene and its gene protein, ABCG2 transport gene, in mesenchymal stem cells.	Oxygen	49-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	160-165
26521940-3	2016	We found that hypoxic stress (0.1% O2) decreased the expression of cytochrome P450 7A1 (CYP7A1), a rate-limiting enzyme involved in bile acid biosynthesis.	Oxygen	35-37	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	67-86
26521940-3	2016	We found that hypoxic stress (0.1% O2) decreased the expression of cytochrome P450 7A1 (CYP7A1), a rate-limiting enzyme involved in bile acid biosynthesis.	Oxygen	35-37	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	88-94
26521940-7	2016	Thus, the results of this study suggested that hypoxia decreased the activity of CYP7A1 by limiting its substrate O2, and by decreasing the transcription of CYP7A1.	Oxygen	114-116	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	81-87
26599446-4	2016	RECENT FINDINGS: ANKH expression is regulated by intracellular levels of oxygen, phosphate and calcium as well as by the growth factor TGF-beta.	Oxygen	73-79	ANKH inorganic pyrophosphate transport regulator	Homo sapiens	17-21
26566615-7	2016	Adjusting oxygen content from 0 to 20 % could increase the DE value from 27.4 to 82.2 % for the M-1 and from 15.8 to 68.9 % for the M-2.	Oxygen	10-16	myoregulin	Homo sapiens	96-99
26760116-0	2016	Low Oxygen Tension Modulates the Insulin-Like Growth Factor-1 or -2 Signaling via Both Insulin-Like Growth Factor-1 Receptor and Insulin Receptor to Maintain Stem Cell Identity in Placental Mesenchymal Stem Cells.	Oxygen	4-10	insulin like growth factor 1	Homo sapiens	33-61
26760116-5	2016	We hypothesized that IGF-1 and IGF-2 signal via distinct signaling pathways under low-oxygen tension to maintain PMSC multipotency.	Oxygen	86-92	insulin like growth factor 1	Homo sapiens	21-26
26760116-6	2016	In preterm PMSCs, low-oxygen tension increased the expression of IGF-2 and reduced IGF-1.	Oxygen	22-28	insulin like growth factor 1	Homo sapiens	83-88
26760116-7	2016	IGF-1 stimulated higher phosphorylation of IGF-1Rbeta, ERK1/2, and AKT, which was maintained at steady lower levels by low oxygen tension.	Oxygen	123-129	insulin like growth factor 1	Homo sapiens	0-5
26760116-7	2016	IGF-1 stimulated higher phosphorylation of IGF-1Rbeta, ERK1/2, and AKT, which was maintained at steady lower levels by low oxygen tension.	Oxygen	123-129	mitogen-activated protein kinase 3	Homo sapiens	55-61
26760116-7	2016	IGF-1 stimulated higher phosphorylation of IGF-1Rbeta, ERK1/2, and AKT, which was maintained at steady lower levels by low oxygen tension.	Oxygen	123-129	AKT serine/threonine kinase 1	Homo sapiens	67-70
26698668-0	2016	Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.	Oxygen	140-146	BTB domain and CNC homolog 1	Homo sapiens	0-5
26760116-9	2016	This IGF/low oxygen tension-mediated proliferation was receptor dependent because neutralization of the IGF-1R inhibited PMSC proliferation in the presence of IGF-1 and the IR in presence of IGF-2.	Oxygen	13-19	insulin like growth factor 1	Homo sapiens	104-109
26760116-11	2016	We conclude that low-oxygen tension can modify the IGF-1 or IGF-2 signaling via the IGF-1R and IR in PMSCs.	Oxygen	21-27	insulin like growth factor 1	Homo sapiens	51-56
26802904-0	2016	Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al.	Oxygen	155-161	BTB domain and CNC homolog 1	Homo sapiens	15-20
26698668-0	2016	Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.	Oxygen	140-146	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
26802904-0	2016	Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al.	Oxygen	155-161	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
26698668-1	2016	The effects of physiological oxygen tension on Nuclear Factor-E2-Related Factor 2 (Nrf2)-regulated redox signaling remain poorly understood.	Oxygen	29-35	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
26698668-2	2016	We report the first study of Nrf2-regulated signaling in human primary endothelial cells (EC) adapted long-term to physiological O2 (5%).	Oxygen	129-131	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
26698668-4	2016	Affymetrix array profiling and subsequent qPCR/protein validation revealed that induction of select Nrf2 target genes, HO-1 and NQO1, was significantly attenuated in cells adapted to 5% O2, despite nuclear accumulation and DNA binding of Nrf2.	Oxygen	186-188	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
26698668-4	2016	Affymetrix array profiling and subsequent qPCR/protein validation revealed that induction of select Nrf2 target genes, HO-1 and NQO1, was significantly attenuated in cells adapted to 5% O2, despite nuclear accumulation and DNA binding of Nrf2.	Oxygen	186-188	NAD(P)H quinone dehydrogenase 1	Homo sapiens	128-132
26698668-4	2016	Affymetrix array profiling and subsequent qPCR/protein validation revealed that induction of select Nrf2 target genes, HO-1 and NQO1, was significantly attenuated in cells adapted to 5% O2, despite nuclear accumulation and DNA binding of Nrf2.	Oxygen	186-188	NFE2 like bZIP transcription factor 2	Homo sapiens	238-242
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	35-37	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
26812880-16	2016	2ME2 is related to vascular endothelial growth factor (VEGF), which regulates blood capillary growth and O2 supply.	Oxygen	105-107	vascular endothelial growth factor A	Homo sapiens	19-53
26812880-16	2016	2ME2 is related to vascular endothelial growth factor (VEGF), which regulates blood capillary growth and O2 supply.	Oxygen	105-107	vascular endothelial growth factor A	Homo sapiens	55-59
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	35-37	BTB domain and CNC homolog 1	Homo sapiens	139-144
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	172-174	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	172-174	BTB domain and CNC homolog 1	Homo sapiens	139-144
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	49-55	glutamate-cysteine ligase modifier subunit	Homo sapiens	39-43
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	49-55	kelch like ECH associated protein 1	Homo sapiens	217-222
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	273-275	NFE2 like bZIP transcription factor 2	Homo sapiens	212-216
26830628-3	2016	We sought to address these disparate reports by reducing the ambient oxygen exposure of ApoE-/- mice.	Oxygen	69-75	apolipoprotein E	Mus musculus	88-92
26989669-2	2016	Thus the aim of this study was determine the effect of recorded mum"s lullaby and Brahm"s lullaby on oxygen saturation in preterm infants.	Oxygen	101-107	latexin	Homo sapiens	64-67
27019453-11	2016	We also observe a significant enr ichment of the highly connected hub genes which could explain differences in prakriti, focussing on EGLN1, a key oxygen sensor that differs between prakriti types and is linked to high altitude adaptation.	Oxygen	147-153	egl-9 family hypoxia inducible factor 1	Homo sapiens	134-139
26830628-4	2016	We observed that long-term adaptation to 10% O2 (equivalent to oxygen content at ~5000 m), compared to 21% O2 (room air at sea level), resulted in a marked decrease in aortic atherosclerosis in ApoE-/- mice.	Oxygen	45-47	apolipoprotein E	Mus musculus	194-198
26830628-9	2016	Anti-inflammatory cytokine IL-10 levels are increased by low ambient O2.	Oxygen	69-71	interleukin 10	Mus musculus	27-32
26830628-11	2016	Absence of IL-10 results in the loss of the anti-atherosclerosis effect of low O2.	Oxygen	79-81	interleukin 10	Mus musculus	11-16
26801054-4	2016	Here, it was found that in most myeloma cell lines tested, HIF1alpha, but not HIF2alpha expression was oxygen dependent, and this could be explained by the differential expression of the regulatory prolyl hydroxylase isoforms.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-68
26850205-8	2016	In addition, mitochondrial oxygen consumption in kidney cortex was measured in the presence of Ang II and hANP.	Oxygen	27-33	angiotensinogen	Homo sapiens	95-101
26850205-8	2016	In addition, mitochondrial oxygen consumption in kidney cortex was measured in the presence of Ang II and hANP.	Oxygen	27-33	natriuretic peptide A	Homo sapiens	106-110
26850205-11	2016	Treatment with hANP significantly attenuated this effect after 4 and 6 h. Oxygen consumption in renal mitochondria increased with the addition of Ang II, which was also attenuated by hANP.	Oxygen	74-80	natriuretic peptide A	Homo sapiens	15-19
26850205-11	2016	Treatment with hANP significantly attenuated this effect after 4 and 6 h. Oxygen consumption in renal mitochondria increased with the addition of Ang II, which was also attenuated by hANP.	Oxygen	74-80	angiotensinogen	Homo sapiens	146-152
26850205-11	2016	Treatment with hANP significantly attenuated this effect after 4 and 6 h. Oxygen consumption in renal mitochondria increased with the addition of Ang II, which was also attenuated by hANP.	Oxygen	74-80	natriuretic peptide A	Homo sapiens	183-187
26821234-10	2016	E2 treatment or PirB silencing markedly decreased hyperoxia-induced apoptosis, increased cell viability and decreased the expression of caspases-3 and -8, and Fas in OPCs, indicating that E2 protects OPCs from hyperoxia-induced apoptosis, predominantly through the downregulation of PirB The results of the present study provide a theoretical basis for the reasonable use of oxygen in Neonatal Intensive Care Units.	Oxygen	375-381	leukocyte immunoglobulin like receptor B2	Rattus norvegicus	16-20
26801054-9	2016	This provides a rationale for targeting the adaptive cellular hypoxic response of the O2-dependent activation of HIFalpha using polyamides.	Oxygen	86-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-121
26896427-8	2016	Hypoxia caused significant increase in AR expression at 6h of oxygen deprivation.	Oxygen	62-68	androgen receptor	Homo sapiens	39-41
25633094-0	2016	GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury.	Oxygen	72-78	golgi phosphoprotein 3	Mus musculus	0-6
25633094-5	2016	The current study found that GOLPH3, an outer membrane protein of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation (OGD/R), positioning from the compact perinuclear ribbon to dispersed vesicle-like structures throughout the cytoplasm.	Oxygen	133-139	golgi phosphoprotein 3	Mus musculus	29-35
26992674-7	2016	We investigated the effect of hypoxia on the expression of Twist1 and GCM1 in primary CTBs cultured with 2% oxygen.	Oxygen	108-114	twist family bHLH transcription factor 1	Homo sapiens	59-65
26742793-2	2016	We tested the hypothesis that inhibition of mTOR would increase infarct size and decrease microregional O2 supply/consumption balance after cerebral ischemia-reperfusion.	Oxygen	104-106	mechanistic target of rapamycin kinase	Homo sapiens	44-48
26742793-11	2016	This suggests that mTOR is important for not only cell survival, but also for the control of oxygen balance after cerebral ischemia-reperfusion.	Oxygen	93-99	mechanistic target of rapamycin kinase	Homo sapiens	19-23
26992688-0	2016	R1 changes in the human placenta at 3 T in response to a maternal oxygen challenge protocol.	Oxygen	66-72	Dopamine 1-like receptor 1	Drosophila melanogaster	0-2
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
26863188-1	2016	Although the oxidation of water is efficiently catalysed by the oxygen-evolving complex in photosystem II (refs 1 and 2), it remains one of the main bottlenecks when aiming for synthetic chemical fuel production powered by sunlight or electricity.	Oxygen	64-70	tissue factor pathway inhibitor 2	Homo sapiens	107-119
26889381-4	2016	HIF-1 alpha is known to orchestrate the expression of numerous genes, many of which code for metabolic enzymes that play key roles in the adaptation of cellular metabolism to low oxygen tension.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
26847407-9	2016	CONCLUSIONS: In non-obese non-diabetic OSA patients, nocturnal oxygen desaturation is strongly associated to insulin resistance.	Oxygen	63-69	insulin	Homo sapiens	109-116
26721561-6	2016	We observe that zebrafish Ngb and Cygb2 have comparable spectral features to those of human Ngb and Cygb, consistent with a six-coordinate heme, whereas unexpectedly Cygb1 has a five-coordinate heme, a slower autoxidation and in general has properties more akin to oxygen transport proteins.	Oxygen	265-271	cytoglobin	Homo sapiens	34-38
26902719-1	2016	An enzyme called p38 MAP kinase helps nematodes to adapt to low-oxygen environments, and also to escape from them.	Oxygen	64-70	mitogen-activated protein kinase 14	Homo sapiens	17-20
26679997-3	2016	One key step to mediate this metabolic adaptation is the stabilization of HIF1alpha, which leads to increased glycolysis and lactate release, as well as decreased oxygen consumption.	Oxygen	163-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-83
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26875667-7	2016	Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner.	Oxygen	76-82	tumor protein p53	Homo sapiens	51-54
26875667-7	2016	Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
26873439-6	2016	RESULTS: The non-angiogenic tumours were distinguished from the angiogenic ones by having higher levels of proteins associated with ephrin pathways, mitochondria, cell biogenesis, and hypoxia-inducible factor 1 (HIF1) regulation by oxygen and transcription of HIF-controlled genes but lower levels of proteins involved in the stroma, cell-cell signaling and adhesion, integrins, and Delta-Notch and epidermal growth factor (EGF)-related signaling.	Oxygen	232-238	hypoxia inducible factor 1 subunit alpha	Homo sapiens	184-210
26859482-12	2016	DC cell culture supplemented with N-acetylcysteine, or alternatively grown in low oxygen, afforded significant proliferative benefits (proliferation: maximum 2-fold increase; NAC: 5-fold p53 decrease; low oxygen: maximum 3.5-fold p53 decrease).	Oxygen	205-211	tumor protein p53	Homo sapiens	230-233
25961932-2	2016	Despite the absence of detectable DNA damage, severe hypoxia (&lt;0.1% O2) induces a DNA damage response, including the activation of p53 and subsequent induction of p53-dependent apoptosis.	Oxygen	71-73	tumor protein p53	Homo sapiens	134-137
25961932-2	2016	Despite the absence of detectable DNA damage, severe hypoxia (&lt;0.1% O2) induces a DNA damage response, including the activation of p53 and subsequent induction of p53-dependent apoptosis.	Oxygen	71-73	tumor protein p53	Homo sapiens	166-169
26924856-4	2016	Spitzer-IRS mid-infrared spectroscopic imaging of the nearby, oxygen-rich planetary nebula NGC 6720 reveals the presence of the 11.3 mum aromatic (PAH) emission band.	Oxygen	62-68	isoleucyl-tRNA synthetase 1	Homo sapiens	8-11
26863487-6	2016	Simultaneously, HIF-1alpha signaling increased glycogen storage, preventing an energy deficit during nutrient or oxygen deprivation.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
26603903-2	2016	Mice lacking PEMT are protected from high-fat diet-induced obesity and insulin resistance, and exhibit increased whole-body energy expenditure and oxygen consumption.	Oxygen	147-153	phosphatidylethanolamine N-methyltransferase	Mus musculus	13-17
26689466-7	2016	The released bFGF significantly improved MSC survival and paracrine effects under low nutrient and oxygen conditions (0% FBS and 1% O2) in vitro.	Oxygen	99-105	fibroblast growth factor 2	Homo sapiens	13-17
26689466-7	2016	The released bFGF significantly improved MSC survival and paracrine effects under low nutrient and oxygen conditions (0% FBS and 1% O2) in vitro.	Oxygen	132-134	fibroblast growth factor 2	Homo sapiens	13-17
26802381-7	2016	Continuous oxygen at 2 L   min-1 via nasal cannula corrected the hypoxia, although P(a)co(2) increased to 6.9 kPa with reduction in pH to the threshold of severe respiratory acidosis (pH 7.25).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	27-32
26841847-1	2016	The activation/inactivation of HIF1alpha is precisely regulated in an oxygen-dependent manner.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-40
26603903-3	2016	Since skeletal muscle is a major site of fatty acid oxidation and energy utilization, we determined if rates of fatty acid oxidation/oxygen consumption in muscle are higher in Pemt(-/-) mice than in Pemt(+/+) mice.	Oxygen	133-139	phosphatidylethanolamine N-methyltransferase	Mus musculus	176-180
26935614-10	2016	CONCLUSION: Hyperbaric oxygen preconditioning protected the integrity of BBB in an in vitro model through modulation of occludin and ZO-1 expression under hypoxic conditions.	Oxygen	23-29	tight junction protein 1	Homo sapiens	133-137
26714229-7	2016	We inhibited mTOR either by rapamycin or small interfering RNA (siRNA) targeting raptor (mTOR complex [mTORC]1) and/or rictor (mTORC2) in HepG2 cells cultured under hypoxia (1% O2) or basal (20% O2) conditions.	Oxygen	177-179	mechanistic target of rapamycin kinase	Homo sapiens	13-17
26820389-9	2016	Hypoxia inhibits oxidative phosphorylation and stimulates the oxygen signalling pathway through the HIF1.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-104
26607244-6	2016	Maximal oxygen consumption in normoxia was 70 +- 2 ml min(-1 )kg(-1) in ATL vs. 43 +- 2 ml min(-1 )kg(-1) in CON, and in hypoxia decreased more in ATL (-41%) than in CON (-25%, P &lt; 0.05).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	54-60
26607244-6	2016	Maximal oxygen consumption in normoxia was 70 +- 2 ml min(-1 )kg(-1) in ATL vs. 43 +- 2 ml min(-1 )kg(-1) in CON, and in hypoxia decreased more in ATL (-41%) than in CON (-25%, P &lt; 0.05).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	91-97
26606288-5	2016	In the particular case of O2(-), [Fe(mpp)3] and [Fe(dmpp)3] (both at 15muM) presented 35% and 22% of inhibition, respectively, while all the other compounds were neither able to scavenge O2(-) nor stimulate its production.	Oxygen	26-28	latexin	Homo sapiens	71-74
27433700-9	2016	The principal mechanism of the adsorption of Pb(II) in the present study is attributed to both ion exchange and oxygen bonding.	Oxygen	112-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	45-51
26776678-0	2016	O2 sensing, mitochondria and ROS signaling: The fog is lifting.	Oxygen	0-2	zinc finger protein, FOG family member 1	Homo sapiens	48-51
26580235-10	2016	The reduction in plasma peptide YY with octreotide positively correlated with the increase in brain reward system blood oxygen level-dependent signal in RYGB/BAND subjects, with a similar trend for glucagon-like peptide-1.	Oxygen	120-126	peptide YY	Homo sapiens	24-34
26714229-7	2016	We inhibited mTOR either by rapamycin or small interfering RNA (siRNA) targeting raptor (mTOR complex [mTORC]1) and/or rictor (mTORC2) in HepG2 cells cultured under hypoxia (1% O2) or basal (20% O2) conditions.	Oxygen	195-197	mechanistic target of rapamycin kinase	Homo sapiens	13-17
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Oxygen	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26499095-0	2016	A discrete role for FNR in the transcriptional response to moderate changes in oxygen by Haemophilus influenzae Rd KW20.	Oxygen	79-85	FNR family transcription factor	Haemophilus influenzae Rd KW20	20-23
26709097-5	2016	Metabolic cage analysis of Riz1(-/-) mice showed lower oxygen consumption but no changes in food intake and ambulatory activity.	Oxygen	55-61	PR domain containing 2, with ZNF domain	Mus musculus	27-31
26499095-6	2016	At these levels of oxygen, even though the growth rate of an H. influenzae fnr mutant was similar to wild type, its ROS and RNS tolerance was significantly different.	Oxygen	19-25	FNR family transcription factor	Haemophilus influenzae Rd KW20	75-78
26499095-7	2016	Additionally, the subtle changes in oxygen did alter the whole cell transcriptional profile and this was different between the wild type and fnr mutant strains.	Oxygen	36-42	FNR family transcription factor	Haemophilus influenzae Rd KW20	141-144
26499095-3	2016	Haemophilus influenzae senses oxygen levels largely through the redox state of the intracellular fumarate-nitrate global regulator (FNR).	Oxygen	30-36	FNR family transcription factor	Haemophilus influenzae Rd KW20	132-135
26909929-0	2016	Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury.	Oxygen	22-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	36-40
26909929-1	2016	We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model.	Oxygen	42-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
26909929-7	2016	Hyperbaric oxygen treatment significantly increased the expression of nuclear Nrf2 protein (P &lt; 0.05), HO-1, and NQO-1 in the brain tissues surrounding the lesion after a traumatic brain injury (P &lt; 0.05) and also significantly reduced the number of apoptotic and injured nerve cells.	Oxygen	11-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
26909929-7	2016	Hyperbaric oxygen treatment significantly increased the expression of nuclear Nrf2 protein (P &lt; 0.05), HO-1, and NQO-1 in the brain tissues surrounding the lesion after a traumatic brain injury (P &lt; 0.05) and also significantly reduced the number of apoptotic and injured nerve cells.	Oxygen	11-17	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	116-121
26909929-9	2016	Therefore, hyperbaric oxygen has a neuroprotective role in traumatic brain injury, which is mediated by up-regulation of the Nrf2 signaling pathway.	Oxygen	22-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
26812205-0	2016	Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-kappaB Signaling Pathway.	Oxygen	11-17	toll-like receptor 4	Rattus norvegicus	87-91
26812205-4	2016	RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappaB signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1beta (P&lt;0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P&lt;0.05).	Oxygen	20-26	toll-like receptor 4	Rattus norvegicus	81-85
26812205-4	2016	RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappaB signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1beta (P&lt;0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P&lt;0.05).	Oxygen	20-26	tumor necrosis factor	Rattus norvegicus	160-169
26812205-4	2016	RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappaB signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1beta (P&lt;0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P&lt;0.05).	Oxygen	20-26	interleukin 6	Rattus norvegicus	171-175
26812205-4	2016	RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappaB signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1beta (P&lt;0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P&lt;0.05).	Oxygen	20-26	interleukin 1 beta	Rattus norvegicus	180-188
26812205-5	2016	CONCLUSIONS: Hyperbaric oxygen therapy protects the neurons after traumatic injury, possibly through inhibition of the TLR4/NF-kappaB signaling pathway.	Oxygen	24-30	toll-like receptor 4	Rattus norvegicus	119-123
26626533-7	2016	In addition, the Ti(3+) species due to the removal of oxygen atoms during calcination and the associated oxygen vacancy defects on the surface of S-TNT could act as hole and electron scavengers, respectively.	Oxygen	54-60	chromosome 16 open reading frame 82	Homo sapiens	148-151
26791224-2	2016	In the nematode Caenorhabditis elegans, a complex of sGCs, GCY-35 and GCY-36, functions in oxygen (O2) sensing.	Oxygen	91-97	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	59-65
26629876-0	2016	Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Abeta Peptide and O2.	Oxygen	58-60	amyloid beta precursor protein	Homo sapiens	74-79
26629876-2	2016	Cu bound to the peptide amyloid-beta (Abeta) is found in AD brains, and Cu-Abeta could contribute to this oxidative stress, as it is able to produce in vitro H2O2 and HO  in the presence of oxygen and biological reducing agents such as ascorbate.	Oxygen	190-196	amyloid beta precursor protein	Homo sapiens	38-43
26629876-2	2016	Cu bound to the peptide amyloid-beta (Abeta) is found in AD brains, and Cu-Abeta could contribute to this oxidative stress, as it is able to produce in vitro H2O2 and HO  in the presence of oxygen and biological reducing agents such as ascorbate.	Oxygen	190-196	amyloid beta precursor protein	Homo sapiens	75-80
26629876-3	2016	The mechanism of Cu-Abeta-catalyzed H2O2 production is however not known, although it was proposed that H2O2 is directly formed from O2 via a 2-electron process.	Oxygen	38-40	amyloid beta precursor protein	Homo sapiens	20-25
26629876-4	2016	Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Abeta in the presence of ascorbate occurs mainly via a free O2 (-) intermediate.	Oxygen	137-139	superoxide dismutase 1	Homo sapiens	71-93
26629876-4	2016	Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Abeta in the presence of ascorbate occurs mainly via a free O2 (-) intermediate.	Oxygen	137-139	superoxide dismutase 1	Homo sapiens	95-99
26629876-4	2016	Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Abeta in the presence of ascorbate occurs mainly via a free O2 (-) intermediate.	Oxygen	137-139	amyloid beta precursor protein	Homo sapiens	157-162
26629876-5	2016	This finding radically changes the view on the catalytic mechanism of H2O2 production by Cu-Abeta, and opens the possibility that Cu-Abeta-catalyzed O2 (-) contributes to oxidative stress in AD, and hence may be of interest.	Oxygen	72-74	amyloid beta precursor protein	Homo sapiens	92-97
26629876-5	2016	This finding radically changes the view on the catalytic mechanism of H2O2 production by Cu-Abeta, and opens the possibility that Cu-Abeta-catalyzed O2 (-) contributes to oxidative stress in AD, and hence may be of interest.	Oxygen	72-74	amyloid beta precursor protein	Homo sapiens	133-138
26731300-8	2016	Mechanistic studies revealed that 2 disrupts the mitochondrial integrity by depolarization of the mitochondrial membrane (IC50 0.6 muM) and permanent opening of the mitochondrial permeability transition pore, leading to increased mitochondrial oxygen consumption and extracellular acidification.	Oxygen	244-250	latexin	Homo sapiens	131-134
26791224-2	2016	In the nematode Caenorhabditis elegans, a complex of sGCs, GCY-35 and GCY-36, functions in oxygen (O2) sensing.	Oxygen	99-101	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	59-65
26727884-4	2016	Factor inhibiting HIF (FIH) is a Fe(2+)/alphaKG-dependent oxygenase that forms part of the O2 sensing machinery in human cells by hydroxylating the C-terminal transactivation domain (CTAD) found within the HIF-1alpha protein.	Oxygen	91-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-216
26765566-0	2016	An oxygen-insensitive Hif-3alpha isoform inhibits Wnt signaling by destabilizing the nuclear beta-catenin complex.	Oxygen	3-9	hypoxia inducible factor 3 subunit alpha	Homo sapiens	22-32
26766745-5	2016	In vitro, the levels of IL-6 release and the levels of IL-6R and STAT3 expression were increased in both primary neurons and astrocytes subjected to oxygen and glucose deprivation (OGD) following MSCs co-culture.	Oxygen	149-155	interleukin 6	Rattus norvegicus	24-28
26766745-5	2016	In vitro, the levels of IL-6 release and the levels of IL-6R and STAT3 expression were increased in both primary neurons and astrocytes subjected to oxygen and glucose deprivation (OGD) following MSCs co-culture.	Oxygen	149-155	interleukin 6 receptor	Rattus norvegicus	55-60
26626533-7	2016	In addition, the Ti(3+) species due to the removal of oxygen atoms during calcination and the associated oxygen vacancy defects on the surface of S-TNT could act as hole and electron scavengers, respectively.	Oxygen	105-111	chromosome 16 open reading frame 82	Homo sapiens	148-151
26754054-1	2016	Idiopathic erythrocytosis is a rare disease characterized by an increase in red blood cell mass due to mutations in proteins of the oxygen-sensing pathway, such as prolyl hydroxylase 2 (PHD2).	Oxygen	132-138	egl-9 family hypoxia inducible factor 1	Homo sapiens	164-184
26754054-1	2016	Idiopathic erythrocytosis is a rare disease characterized by an increase in red blood cell mass due to mutations in proteins of the oxygen-sensing pathway, such as prolyl hydroxylase 2 (PHD2).	Oxygen	132-138	egl-9 family hypoxia inducible factor 1	Homo sapiens	186-190
26620226-11	2016	The results of the present study suggest that pTr cells adapt to oxygen deficiency and proliferate in response to an oxygen-dependent HIF-1 system, and that EGF at maternal-conceptus interface can increase the abundance of HIF-1alpha protein via translational regulation through AKT, ERK1/2 and mTOR signaling cascades.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
26620226-2	2016	Hypoxia-inducible factor (HIF)-1 is a master regulator whereby cells adapt to changes in oxygen concentrations.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
26620226-11	2016	The results of the present study suggest that pTr cells adapt to oxygen deficiency and proliferate in response to an oxygen-dependent HIF-1 system, and that EGF at maternal-conceptus interface can increase the abundance of HIF-1alpha protein via translational regulation through AKT, ERK1/2 and mTOR signaling cascades.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-233
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	Oxygen	62-68	ferrochelatase	Rattus norvegicus	124-138
26740011-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylation and degradation.	Oxygen	135-141	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
26740011-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylation and degradation.	Oxygen	135-141	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
26740011-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylation and degradation.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-248
26740011-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylation and degradation.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	250-260
27343101-0	2016	Optical Analysis of Hypoxia Inducible Factor (HIF)-1 Complex Assembly: Imaging of Cellular Oxygen Sensing.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-52
26727049-6	2016	The in vitro analysis showed that LCC6(HER-2) cells become more hypoxic in 1% oxygen and utilise significantly more glucose in normoxia compared to LCC6(Vector)cells (p &lt; 0.005).	Oxygen	78-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-44
26727049-7	2016	Amalgamation of all the data points suggests a novel metabolic adaptation driven by HER-2 overexpression where higher oxygen and glucose metabolic rates produce rich energy supply but also a more hypoxic tumour mass.	Oxygen	118-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-89
27343101-3	2016	Genetic adaptation to hypoxia is under control of hypoxia-inducible factors (HIFs), of which two highly homologous subunits HIF-1alpha and HIF-2alpha are regulated by oxygen tension.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
27430909-2	2016	Because HIF-1[Formula: see text] is instable with oxygen, HIF-1 is scarce in normal mammalian cells.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-13
26782203-7	2016	NO production declined with decreasing oxygen concentration given that oxygen is a substrate for nitric oxide synthase (NOS).	Oxygen	39-45	nitric oxide synthase 2	Homo sapiens	97-118
26782203-7	2016	NO production declined with decreasing oxygen concentration given that oxygen is a substrate for nitric oxide synthase (NOS).	Oxygen	71-77	nitric oxide synthase 2	Homo sapiens	97-118
26782237-0	2016	Local Measurement of Flap Oxygen Saturation: An Application of Visible Light Spectroscopy.	Oxygen	26-32	arachidonate 5-lipoxygenase activating protein	Homo sapiens	21-25
26782245-13	2016	Whilst, betaLys66Tyr and rwt autoxidised (oxy to met) at similar rates, the oxygen p50 for betaLys66Tyr was very low.	Oxygen	76-82	nuclear factor kappa B subunit 1	Homo sapiens	83-86
26727534-11	2016	The effects of HF-rTMS on dACC blood oxygen level-dependent response were negatively correlated with the baseline dACC activation.	Oxygen	37-43	Acetyl-CoA carboxylase	Drosophila melanogaster	26-30
26727534-11	2016	The effects of HF-rTMS on dACC blood oxygen level-dependent response were negatively correlated with the baseline dACC activation.	Oxygen	37-43	Acetyl-CoA carboxylase	Drosophila melanogaster	114-118
26546248-6	2016	CRP levels predicted shorter exercise times (R = -0.65, p = 0.006), lower oxygen consumption (VO2) at the anaerobic threshold (R = -0.66, p = 0.005), and lower peak VO2 (R = -0.70, p = 0.002), reflecting worse cardiovascular performance.	Oxygen	74-80	C-reactive protein	Homo sapiens	0-3
26546248-7	2016	CRP levels also significantly correlated with an elevated ventilation/carbon dioxide production slope (R = +0.64, p = 0.008), a reduced oxygen uptake efficiency slope (R = -0.55, p = 0.026), and reduced end-tidal CO2 level at rest and with exercise (R = -0.759, p = 0.001 and R = -0.739, p = 0.001, respectively), reflecting impaired gas exchange.	Oxygen	136-142	C-reactive protein	Homo sapiens	0-3
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27040637-1	2016	Hypoxia-inducible factor (HIF)-1alpha is a transcription factor belonging to the HIF family that is activated in mammalian cells during conditions of low oxygen tension or hypoxia to induce an adaptive response and promote cell survival.	Oxygen	154-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
26667076-3	2016	Due to the daily changes in tissue oxygen levels in the intestine, the hypoxic transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are essential in maintaining intestinal homeostasis.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-138
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Oxygen	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
26523859-2	2016	However, oxygen tension influences MMP/TIMP balances, potentially leading to pathology.	Oxygen	9-15	TIMP metallopeptidase inhibitor 1	Homo sapiens	39-43
27648004-1	2016	This paper introduces the structural characterization and studies on reversible oxygenation behavior of a new oxygen carrier Co(II)-2,4-diaminobutanoic acid (DABA) complex in aqueous solution.	Oxygen	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
26523859-3	2016	Intriguingly, new 2H,3H-decafluoropentane-based oxygen-loaded nanodroplets (OLNDs) have proven effective in abrogating hypoxia-dependent dysregulation of MMP and TIMP secretion by single cell populations.	Oxygen	48-54	TIMP metallopeptidase inhibitor 1	Homo sapiens	162-166
26523859-6	2016	Explants cultured at higher oxygen tension released constitutive proMMP-2, proMMP-9, TIMP-1, and TIMP-2.	Oxygen	28-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	85-91
26785721-3	2016	Hypoxia-inducible factor-1 (HIF-1alpha) is a master regulator of the transcriptional response to oxygen deprivation in cancer cells.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
28396525-5	2016	We review here two bypass mechanisms that either instigate angiogenic and immune-suppressive polarization of intratumoral innate immune cells to facilitate VEGF-independent angiogenesis or enable metabolic adaptation and reprogramming of endothelial cells and tumor cells to adapt to low-oxygen tension.	Oxygen	288-294	vascular endothelial growth factor A	Homo sapiens	156-160
27197977-0	2016	Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-x03BA; B-Mediated Signaling Pathway.	Oxygen	11-17	toll-like receptor 4	Rattus norvegicus	136-140
26726739-9	2016	Moreover, the inhibition of Abeta aggregation was achieved via oxygenation (i.e., incorporation of oxygen atoms to Abeta) using an artificial catalyst.	Oxygen	63-69	amyloid beta precursor protein	Homo sapiens	28-33
26711465-7	2016	Copeptin was significantly positively correlated with B-type natriuretic peptide (r = 0.434, p &lt; 0.001), D-dimer (r = 0.315, p = 0.003) and troponin I (r = 0.300, p = 0.004) and inversely correlated with arterial oxygen saturations (r = -0.533, p &lt; 0001).	Oxygen	216-222	arginine vasopressin	Homo sapiens	0-8
26391043-3	2016	Much of the oxidative damage of proteins is brought about by the overproduction of nitric oxide by nitric oxide synthases (NOS) and its subsequent reactivity with reactive oxygen species.	Oxygen	172-178	nitric oxide synthase 2	Homo sapiens	99-121
26055405-7	2016	About 60% of the O2 consumption in yeastless dough is ascribed to oxidation of fatty acids by wheat lipoxygenase activity.	Oxygen	17-19	LOC543232	Triticum aestivum	100-112
26055405-8	2016	In yeasted dough, about 70% of the O2 in dough is consumed by yeast and wheat lipoxygenase.	Oxygen	35-37	LOC543232	Triticum aestivum	78-90
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
27464520-2	2016	It is produced from the amino acid L-Arginine and oxygen by the enzymatic action of three isoforms of the Nitric Oxide Synthase (NOS), differently expressed and regulated in tissues.	Oxygen	50-56	nitric oxide synthase 2	Homo sapiens	106-127
25708430-4	2016	In diabetic animals, sufficient nutrition and oxygen supply to islets grafted in the CNS provide adequate insulin response to increase glucose level resulting in rapid normoglycemia.	Oxygen	46-52	insulin	Homo sapiens	106-113
26794506-1	2016	Catalase is responsible for converting hydrogen peroxide (H2O2) into water and oxygen in cells.	Oxygen	79-85	catalase	Mus musculus	0-8
26556270-6	2016	On the other hand, recent studies have shown that adipose tissue oxygen tension was actually higher (hyperoxia) than normal and associated with insulin resistance in obesity, despite a reduction in blood flow.	Oxygen	65-71	insulin	Homo sapiens	144-151
26453314-5	2016	Hypoxia-inducible factor-1 (HIF-1, a heterodimer of HIF-1alpha and HIF-1beta) is a master regulator of oxygen homeostasis that mediates the adaptive cellular responses to hypoxia by regulating the expression of genes involved in angiogenesis, metabolic changes, proliferation, migration, and cell survival.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
26453314-5	2016	Hypoxia-inducible factor-1 (HIF-1, a heterodimer of HIF-1alpha and HIF-1beta) is a master regulator of oxygen homeostasis that mediates the adaptive cellular responses to hypoxia by regulating the expression of genes involved in angiogenesis, metabolic changes, proliferation, migration, and cell survival.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
28003846-5	2016	A 24-week treatment of PF especially in the dosage of 40 mg/kg d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.	Oxygen	79-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	190-194
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	35-41	erythropoietin	Homo sapiens	79-93
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	35-41	vascular endothelial growth factor A	Homo sapiens	122-156
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	326-331
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	217-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	217-223	erythropoietin	Homo sapiens	79-93
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	217-223	vascular endothelial growth factor A	Homo sapiens	122-156
26391197-3	2016	The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which makes HIF-1 an interesting candidate as a mediator of skeletal muscle adaptation to endurance training.	Oxygen	217-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	326-331
26391197-4	2016	However, HIF-1 may also inhibit cellular oxygen consumption and mitochondrial oxidative metabolism, features discordant with the phenotype of a trained muscle.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-14
26608793-5	2016	HIF-1 activity depends on the HIF-1alpha subunit level which is regulated by oxygen, nitric oxide (NO), reactive oxygen species and mTOR.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
27003382-0	2016	Pigment Epithelium-Derived Factor Inhibits Oxygen-Induced Retinal Neovascularization in a Murine Model.	Oxygen	43-49	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	0-33
26608793-5	2016	HIF-1 activity depends on the HIF-1alpha subunit level which is regulated by oxygen, nitric oxide (NO), reactive oxygen species and mTOR.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
29975476-1	2016	The purpose of this work was to define dependence of maintenance of myeloperoxidase (MPO) in plasma of blood of patients by the acute infarct of myocardium from the state of oxygen metabolism of neutrophils, which was estimated on activity of myeloperoxidases, superoxid-anion and catalase in cells and on maintenance by peroxigens.	Oxygen	174-180	myeloperoxidase	Homo sapiens	68-83
29975476-1	2016	The purpose of this work was to define dependence of maintenance of myeloperoxidase (MPO) in plasma of blood of patients by the acute infarct of myocardium from the state of oxygen metabolism of neutrophils, which was estimated on activity of myeloperoxidases, superoxid-anion and catalase in cells and on maintenance by peroxigens.	Oxygen	174-180	myeloperoxidase	Homo sapiens	85-88
26358273-0	2016	S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression.	Oxygen	25-31	S100 calcium binding protein A4	Mus musculus	0-6
26729624-0	2016	Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia brain damage by activating Nrf2 expression in vivo and in vitro.	Oxygen	11-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
26729624-1	2016	The present study aimed to investigate whether hyperbaric oxygen preconditioning (HBO-PC) could ameliorate hypoxia-ischemia brain damage (HIBD) by an increase of Nrf2 expression.	Oxygen	58-64	NFE2 like bZIP transcription factor 2	Rattus norvegicus	162-166
26358273-0	2016	S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression.	Oxygen	25-31	cAMP responsive element binding protein 1	Mus musculus	120-124
27747290-9	2016	Mechanistic studies on PER2 mediated cardioprotection revealed an important role for PER2 in optimizing cardiac metabolism through activation of oxygen saving pathways.	Oxygen	145-151	period circadian clock 2	Mus musculus	23-27
27720550-6	2016	Oxygen is a major risk factor for ROP and during the phase 2 study oxygen saturation targets were increased to 90-95%, due to national guidelines, which might have affected ROP rate and severity making increased IGF-I a weaker preventative factor for ROP.	Oxygen	0-6	insulin like growth factor 1	Homo sapiens	212-217
27720550-6	2016	Oxygen is a major risk factor for ROP and during the phase 2 study oxygen saturation targets were increased to 90-95%, due to national guidelines, which might have affected ROP rate and severity making increased IGF-I a weaker preventative factor for ROP.	Oxygen	67-73	insulin like growth factor 1	Homo sapiens	212-217
27525289-3	2016	Accumulation of HIF-1alpha under hypoxia is mainly controlled by the oxygen-sensing HIF prolyl 4-hydroxylases (EGLNs, also known as PHDs).	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
26887694-0	2016	Effect of oxygen pressure during incubation with a (10)B-carrier on (10)B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of (10)B-carriers.	Oxygen	10-16	tumor protein p53	Homo sapiens	102-105
26639961-4	2016	These results support a relationship between the aggregation of Abeta protein plaques in the neocortex, increased cognitive impairment, and more inefficient myocardial oxygen use in the absence of significant metabolic demands.	Oxygen	168-174	amyloid beta precursor protein	Homo sapiens	64-69
26147348-1	2016	It has been reported that beta amyloid induces production of radical oxygen species and oxidative stress in neuronal cells, which in turn upregulates beta-secretase (BACE-1) expression and beta amyloid levels, thereby propagating oxidative stress and increasing neuronal injury.	Oxygen	69-75	beta-secretase 1	Homo sapiens	166-172
27403445-12	2016	In culture, macrophages exposed to cigarette smoke and oxygen also demonstrated decreased TNF-alpha secretion and enhanced phagocytosis of PAO1 bacteria.	Oxygen	55-61	tumor necrosis factor	Mus musculus	90-99
27003382-1	2016	BACKGROUND: The inhibitory effects of pigment epithelium-derived factor (PEDF) on retinal neovascularization were observed in a murine model of oxygen-induced retinopathy.	Oxygen	144-150	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	38-71
27003382-1	2016	BACKGROUND: The inhibitory effects of pigment epithelium-derived factor (PEDF) on retinal neovascularization were observed in a murine model of oxygen-induced retinopathy.	Oxygen	144-150	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	73-77
27747290-9	2016	Mechanistic studies on PER2 mediated cardioprotection revealed an important role for PER2 in optimizing cardiac metabolism through activation of oxygen saving pathways.	Oxygen	145-151	period circadian clock 2	Mus musculus	85-89
26477504-0	2016	Superoxide dismutase 1 and glutathione peroxidase 1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose deprivation.	Oxygen	145-151	superoxide dismutase 1	Homo sapiens	0-22
27518620-1	2016	The hypoxia-inducible factor 1 (HIF-1) is a transcriptional factor involved in the regulation of oxygen within cellular environments.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
27518620-1	2016	The hypoxia-inducible factor 1 (HIF-1) is a transcriptional factor involved in the regulation of oxygen within cellular environments.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
27518620-2	2016	In hypoxic tissues or those with inadequate oxygen concentrations, activation of the HIF-1 transcription factor allows for subsequent activation of target gene expression implicated in cell survival.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-90
28191549-4	2016	Anti-VEGF treatment can normalize the tumor vasculature, improving vessel perfusion and delivery of oxygen.	Oxygen	100-106	vascular endothelial growth factor A	Homo sapiens	5-9
28191549-5	2016	It is known that oxygen is a potent radiosensitizer; therefore, combining anti-VEGF treatment with radiation therapy can achieve better tumor control and allow for the use of lower radiation doses, thus minimizing treatment-related neurological toxicity.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	79-83
26859849-2	2016	In this segment, while transport is increased by ADH via cAMP, sodium reabsorption results from Ang II-induced superoxide (O2(-)) production.	Oxygen	123-125	angiotensinogen	Rattus norvegicus	96-102
26763345-6	2016	In addition, MRS3 expressed from a high copy number vector was able to suppress the oxygen consumption and copper uptake defects of a strain lacking PIC2.	Oxygen	84-90	Fe(2+) transporter	Saccharomyces cerevisiae S288C	13-17
26859849-5	2016	METHODS: The effect of ADH/Ang II in TALs from spontaneously hypertensive rats (SHR) on oxygen consumption (QO2), cAMP and O2(-) was measured.	Oxygen	88-94	angiotensinogen	Rattus norvegicus	27-33
26859849-9	2016	These accumulative effects could be due to nitric oxide synthase (NOS) uncoupling, lower Ang II ability to decrease cAMP or increased O2(-).	Oxygen	134-136	angiotensinogen	Rattus norvegicus	89-95
26859849-16	2016	We conclude that (1) in SHR, Ang II has accumulative effects on ADH-stimulated transport; (2) this effect is mediated by AT1 receptors, and increased O2(-) production.	Oxygen	150-152	angiotensinogen	Rattus norvegicus	29-35
27251645-6	2016	During this phase, VEGF levels increase, especially if there is retinal hypoxia with increasing retinal metabolism and demand for oxygen leading to abnormal vasoproliferation.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	19-23
27974949-0	2016	Partial Oxygen Pressure Affects the Expression of Prognostic Biomarkers HIF-1 Alpha, Ki67, and CK20 in the Microenvironment of Colorectal Cancer Tissue.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-83
27597885-0	2016	Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation.	Oxygen	24-30	dynamin 1-like	Mus musculus	83-87
27974949-0	2016	Partial Oxygen Pressure Affects the Expression of Prognostic Biomarkers HIF-1 Alpha, Ki67, and CK20 in the Microenvironment of Colorectal Cancer Tissue.	Oxygen	8-14	keratin 20	Homo sapiens	95-99
26748156-1	2016	During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF).	Oxygen	73-79	vascular endothelial growth factor A	Homo sapiens	152-186
26748156-1	2016	During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF).	Oxygen	73-79	vascular endothelial growth factor A	Homo sapiens	188-192
26748156-8	2016	Low oxygen significantly increased the expression of both angiotensin II type 1 receptor (AGTR1) and VEGF (both P &lt; 0.05).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	101-105
26748156-9	2016	There was a positive correlation between AGTR1 and VEGF expression at low oxygen (r = 0.64, P &lt; 0.005).	Oxygen	74-80	vascular endothelial growth factor A	Homo sapiens	51-55
26748156-10	2016	Corresponding increases in VEGF protein were observed with low oxygen (P &lt; 0.05).	Oxygen	63-69	vascular endothelial growth factor A	Homo sapiens	27-31
26748156-13	2016	Low oxygen increased AGTR1 and VEGF expression, as well as ACE and VEGF protein levels, suggesting that the proangiogenic RAS pathway is activated.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	31-35
26499794-5	2015	Additionally, a potential role for O2 in catalysis by the RPE65 group of CCOs has not been evaluated to date.	Oxygen	35-37	retinoid isomerohydrolase RPE65	Bos taurus	58-63
26719776-2	2015	Myeloperoxidase plays an important role in oxygen-dependent killing of bacteria, fungi, virus and malignant cells.	Oxygen	43-49	myeloperoxidase	Homo sapiens	0-15
26876188-1	2015	The aim of this study was to assess circulating levels of reactive oxygen metabolites (ROMs) as a marker of oxidative stress in rheumatoid arthritis (RA) patients during an anti-tumor necrosis factor alpha (TNF-alpha) treatment.	Oxygen	67-73	tumor necrosis factor	Homo sapiens	207-216
26341689-6	2015	Upon co-expression of splice variant Rac1b, but not of Rac1, the B-Raf-induced senescence phenotype was reverted and expression of the cell-cycle inhibitors downregulated in a reactive oxygen-species dependent manner.	Oxygen	185-191	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	65-70
26568481-3	2015	We use several theoretical descriptors to categorize these species, focusing our attention on the interaction between the carbene carbon and the methanol oxygen, CcO, because this is the key interaction in the formation of O-ylides, ether products, and O-ylidic solvation complexes.	Oxygen	154-160	ryanodine receptor 1	Homo sapiens	162-165
26711269-4	2015	Depletion of Lrp5 decreases glucose uptake, lactate secretion, and oxygen consumption rates; inhibition of glucose consumption phenocopies the loss of Lrp5 function.	Oxygen	67-73	LDL receptor related protein 5	Homo sapiens	13-17
26680696-3	2015	HIF-1alpha is degraded through the prolyl hydroxylase (PHD)/von Hippel-Lindau (VHL) ubiquitination pathway in an oxygen-dependent manner.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
26526962-0	2015	Oxygen-Controlled Catalysis by Vitamin B12 -TiO2 : Formation of Esters and Amides from Trichlorinated Organic Compounds by Photoirradiation.	Oxygen	0-6	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	39-42
26674118-3	2015	Here we identify IL-8 as a hypoxia-regulated cytokine in both AML cell lines and primary AML samples that is induced within 48 hours of severe hypoxia (1% O2).	Oxygen	155-157	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26526962-1	2015	An oxygen switch in catalysis of the cobalamin derivative (B12 )-TiO2 hybrid catalyst for the dechlorination of trichlorinated organic compounds has been developed.	Oxygen	3-9	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	59-62
26361075-1	2015	The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans.	Oxygen	92-98	Hypoxia-inducible factor 1	Caenorhabditis elegans	25-51
26671371-2	2015	These data illustrate the ability of field enhanced photoemission (FEP) to determine V0(rho) accurately in strongly absorbing fluids (e.g., O2) and fluids with extremely low critical temperatures (e.g., H2 and D2).	Oxygen	140-142	rhodopsin	Homo sapiens	85-92
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	ATP binding cassette subfamily B member 1	Homo sapiens	97-111
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	ATP binding cassette subfamily C member 1	Homo sapiens	150-154
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	234-265
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	267-277
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	ATP binding cassette subfamily B member 1	Homo sapiens	280-284
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	ATP binding cassette subfamily C member 1	Homo sapiens	285-289
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	97-111
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily C member 1	Homo sapiens	150-154
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	234-265
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	267-277
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	280-284
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily C member 1	Homo sapiens	285-289
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	97-111
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily C member 1	Homo sapiens	150-154
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	234-265
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	267-277
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily B member 1	Homo sapiens	280-284
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	ATP binding cassette subfamily C member 1	Homo sapiens	285-289
26587763-2	2015	Under H2O and H2 atmospheres, hydrogens derived from H2O or H2 molecules were introduced into the oxygen sites as a hydride ion, and SmFeAsO(1-x)Hx was obtained.	Oxygen	98-104	fibroblast growth factor receptor 1	Homo sapiens	6-16
26587763-3	2015	However, when the H2O and H2 sources were removed from the synthetic process, nearly stoichiometric SmFeAsO was obtained and the maximum amount of oxygen vacancies introduced remained x = 0.05(4).	Oxygen	147-153	fibroblast growth factor receptor 1	Homo sapiens	18-28
26653189-0	2015	Characteristics of Alpha-1 Antitrypsin-Deficient Individuals in the Long-term Oxygen Treatment Trial and Comparison with Other Subjects with Chronic Obstructive Pulmonary Disease.	Oxygen	78-84	serpin family A member 1	Homo sapiens	19-38
26658212-6	2015	Gas exchange tests also revealed that at a porcine blood flow rate of 5 l min(-1), O2 and CO2 exchange rates through the PSF-PEGA membrane were 198.6 and 170.9 ml min(-1), respectively; approximately this is the gas exchange capacity of commercial respiratory assistance devices.	Oxygen	83-85	insulin like growth factor binding protein 7	Homo sapiens	121-124
26361075-1	2015	The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans.	Oxygen	92-98	Hypoxia-inducible factor 1	Caenorhabditis elegans	53-58
26351913-4	2015	In contrast, reduced oxygen availability inhibits PHD activity resulting in HIF-1alpha stabilisation and nuclear accumulation.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
26338830-1	2015	PURPOSE: Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat.	Oxygen	63-65	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
26514431-3	2015	Since the oxygen-sensitive HIF-1alpha subunit is stabilized during hypoxia, it functions as the regulatory subunit of the protein.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
26298291-2	2015	Drop in ambient oxygen pressure likely results in a decrease in muscle cells oxygenation, reactive oxygen species (ROS) overproduction and stabilization of the oxygen-sensitive hypoxia-inducible factor (HIF)-1alpha.	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-214
25855771-11	2015	Furthermore, in cultured human podocytes exposed to HG, TxNIP knockdown with siRNA abolished the increased mitochondrial O2 (-) generation and apoptosis.	Oxygen	121-123	thioredoxin interacting protein	Homo sapiens	56-61
26531845-7	2015	Eighty-eight genes were differentially expressed between cells cultured in 1% oxygen (where HIF-1alpha protein was localised to the nucleus) and 5% oxygen (where HIF-1alpha was mainly cytoplasmic).	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
26531845-7	2015	Eighty-eight genes were differentially expressed between cells cultured in 1% oxygen (where HIF-1alpha protein was localised to the nucleus) and 5% oxygen (where HIF-1alpha was mainly cytoplasmic).	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-172
26531845-7	2015	Eighty-eight genes were differentially expressed between cells cultured in 1% oxygen (where HIF-1alpha protein was localised to the nucleus) and 5% oxygen (where HIF-1alpha was mainly cytoplasmic).	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-172
26459773-0	2015	CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.	Oxygen	69-75	cellular communication network factor 1	Mus musculus	0-4
26459773-0	2015	CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.	Oxygen	69-75	cellular communication network factor 1	Mus musculus	5-10
26459773-0	2015	CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.	Oxygen	69-75	thymoma viral proto-oncogene 1	Mus musculus	16-19
26459773-6	2015	In addition, mouse pups with oxygen-induced retinopathy (OIR) were administered an intravitreal injection of CCN1 siRNA.	Oxygen	29-35	cellular communication network factor 1	Mus musculus	109-113
26399516-9	2015	Consistent with previous findings, irisin significantly increased expression of several genes including peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) leading to increased mitochondrial content and oxygen consumption.	Oxygen	232-238	PPARG coactivator 1 alpha	Homo sapiens	104-171
26449597-4	2015	The key regulatory component, hypoxia-inducible factor (HIF)-1alpha (HIF-1alpha) was stabilized at 5 h in 5 % oxygen for all three studied regimens, i.e. in glycolytic cells at 5 mM or 25 mM glucose, or in aglycemic (OXPHOS) cells when glucose was replaced by galactose.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-67
26449597-4	2015	The key regulatory component, hypoxia-inducible factor (HIF)-1alpha (HIF-1alpha) was stabilized at 5 h in 5 % oxygen for all three studied regimens, i.e. in glycolytic cells at 5 mM or 25 mM glucose, or in aglycemic (OXPHOS) cells when glucose was replaced by galactose.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
26449597-5	2015	However, the conventional HIF-mediated suppression of respiration was prevented at aglycemia, which correlated with a high proportion of unphosphorylated pyruvate dehydrogenase (PDH) at 5 % oxygen.	Oxygen	190-196	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	154-176
26449597-5	2015	However, the conventional HIF-mediated suppression of respiration was prevented at aglycemia, which correlated with a high proportion of unphosphorylated pyruvate dehydrogenase (PDH) at 5 % oxygen.	Oxygen	190-196	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	178-181
26215820-10	2015	NTV ventilation with 60 % O2 attenuated the increase in chemokine (C-X-C motif) ligand (CXCL)-1 secretion and neutrophil accumulation observed in the atelectatic lungs, but that with 100 % N2 did not.	Oxygen	26-28	chemokine (C-X-C motif) ligand 1	Mus musculus	67-95
26399516-9	2015	Consistent with previous findings, irisin significantly increased expression of several genes including peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) leading to increased mitochondrial content and oxygen consumption.	Oxygen	232-238	PPARG coactivator 1 alpha	Homo sapiens	173-183
26233464-3	2015	Glutamine synthetase is also thought to be especially sensitive to inactivation by the oxygen- and nitrogen-centered radicals generated during strokes.	Oxygen	87-93	glutamate-ammonia ligase	Homo sapiens	0-20
26553865-3	2015	AIM: The aim of this study was to investigate the effect of varying doses of sildenafil on the p50 of the oxygen-hemoglobin dissociation curve in blood samples from eight (8) healthy adult male volunteers with normal hemoglobin HbAA.	Oxygen	106-112	nuclear factor kappa B subunit 1	Homo sapiens	95-98
26553865-7	2015	CONCLUSION: Sildenafil caused a dose-dependent increase in the release of oxygen from the erythrocytes as shown by the increased p50 values and rightward shift of the oxygen-hemoglobin dissociation curve.	Oxygen	74-80	nuclear factor kappa B subunit 1	Homo sapiens	129-132
26558482-6	2015	Theoretical studies show the 3d electrons in chromium are removed by O( -) for CrOn(NO3)(4-n)(-), n = 1-3, to yield oxo, O(2-) ligands, but the electron density is replaced by donation from pi bonds involving the oxygen lone pairs.	Oxygen	213-219	NBL1, DAN family BMP antagonist	Homo sapiens	84-87
26617391-6	2015	Here we show that 25% of AML patients down-regulate FLT3 expression on blasts in response to in vitro hypoxia (1% O2), which was independent of its mutational state.	Oxygen	114-116	fms related receptor tyrosine kinase 3	Homo sapiens	52-56
26617391-11	2015	In conclusion, FLT3 expression in AML is dependent on the oxygen partial pressure, but response to hypoxia differs.	Oxygen	58-64	fms related receptor tyrosine kinase 3	Homo sapiens	15-19
26611735-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension.	Oxygen	180-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26611735-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension.	Oxygen	180-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
26611735-2	2015	The stability of HIF-1alpha protein is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
26611735-2	2015	The stability of HIF-1alpha protein is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	227-237
26554010-5	2015	It is known that oxygen is a potent radiosensitizer; therefore, we further demonstrated that combining anti-VEGF with radiation therapy can achieve a better tumor control and help lower the radiation dose and, thus, minimize radiation-related neurological toxicity.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	108-112
26588727-5	2015	To advance the mechanistic understanding of oxygen sensing in hypoxia, we demonstrated that the rate of HIF-1alpha nuclear import substantially influences its stabilization and the formation of HIF-1 transcription factor complex.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
26588727-6	2015	We described the biological feedback loops involving let-7 and AGO1 in which the impact of external perturbations were minimized; as a pair of master regulators when low oxygen tension was sensed, they coordinated the critical process of VEGF desuppression in a controlled manner.	Oxygen	170-176	argonaute RISC component 1	Homo sapiens	63-67
26590427-3	2015	During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and the ER stress response.	Oxygen	7-9	mechanistic target of rapamycin kinase	Homo sapiens	118-122
26588727-6	2015	We described the biological feedback loops involving let-7 and AGO1 in which the impact of external perturbations were minimized; as a pair of master regulators when low oxygen tension was sensed, they coordinated the critical process of VEGF desuppression in a controlled manner.	Oxygen	170-176	vascular endothelial growth factor A	Homo sapiens	238-242
26610526-1	2015	Hypoxia inducible factor-1alpha (HIF-1alpha) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26610526-1	2015	Hypoxia inducible factor-1alpha (HIF-1alpha) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
26610526-1	2015	Hypoxia inducible factor-1alpha (HIF-1alpha) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26610526-1	2015	Hypoxia inducible factor-1alpha (HIF-1alpha) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
26567667-0	2015	Size and structure effects of PtN (N = 12 - 13) clusters for the oxygen reduction reaction: First-principles calculations.	Oxygen	65-71	pleiotrophin	Homo sapiens	30-33
26386109-0	2015	Selective TNF-alpha targeting with infliximab attenuates impaired oxygen metabolism and contractile function induced by an acute exposure to air particulate matter.	Oxygen	66-72	tumor necrosis factor	Mus musculus	10-19
26572229-4	2015	HIF-1alpha is regulated in an oxygen-dependent manner whereas ARNT is considered to be constitutively expressed.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
26567667-1	2015	Size and structure effects on the oxygen reduction reaction on PtN clusters with N = 12-13 atoms have been investigated using periodic density functional theory calculations with the generalized gradient approximation.	Oxygen	34-40	pleiotrophin	Homo sapiens	63-66
26446170-8	2015	Additionally, mas1 mitochondria respond to temperature elevation with an increase in membrane potential and oxygen consumption.	Oxygen	108-114	MAS1 proto-oncogene, G protein-coupled receptor	Homo sapiens	14-18
26427541-1	2015	We investigate, by means of density-functional theory, the binding of dioxygen to Cu(I)-amyloid beta (Abeta), one of the first steps in the oxidation of ascorbate by dioxygen.	Oxygen	166-174	amyloid beta precursor protein	Homo sapiens	102-107
26498856-0	2015	The PHD2 oxygen sensor paves the way to metastasis.	Oxygen	9-15	egl-9 family hypoxia inducible factor 1	Homo sapiens	4-8
26542760-6	2015	Confocal microscopy analysis of cardiac cells revealed that apelin prevents nuclear translocation of FoxO3 in response to oxygen deprivation through a PI3K pathway.	Oxygen	122-128	apelin	Homo sapiens	60-66
26542760-6	2015	Confocal microscopy analysis of cardiac cells revealed that apelin prevents nuclear translocation of FoxO3 in response to oxygen deprivation through a PI3K pathway.	Oxygen	122-128	forkhead box O3	Homo sapiens	101-106
26427541-1	2015	We investigate, by means of density-functional theory, the binding of dioxygen to Cu(I)-amyloid beta (Abeta), one of the first steps in the oxidation of ascorbate by dioxygen.	Oxygen	70-78	amyloid beta precursor protein	Homo sapiens	102-107
26601842-4	2015	LPO processes were more active in Buryat men, which can indicate exposure of cell membranes to toxic oxygen species.	Oxygen	101-107	lactoperoxidase	Homo sapiens	0-3
26327596-5	2015	Incubation of hepatocytes with TNFalpha increased CL content 15% (p&lt;0.05), mitochondrial oxygen consumption 33% (p&lt;0.05), PGPS gene expression 44% (p&lt;0.05) and MLCL AT-1 activity 20% (p&lt;0.05) compared to controls.	Oxygen	92-98	tumor necrosis factor	Rattus norvegicus	31-39
26823875-10	2015	Interactions were existed between NOS3 gene polymorphisms and oxygen therapy duration.	Oxygen	62-68	nitric oxide synthase 3	Homo sapiens	34-38
26194803-1	2015	von Hippel-Lindau (pVHL)-mediated ubiquitination of HIF-1alpha plays a central role in the cellular responses to changes in oxygen availability.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha a	Danio rerio	52-62
26215374-4	2015	The effect of classical activators (lipopolysaccharide, LPS; interferon-gamma, IFN-gamma) was further potentiated with hypoxic (5% O2) conditions.	Oxygen	131-133	interferon gamma	Homo sapiens	61-77
26215374-4	2015	The effect of classical activators (lipopolysaccharide, LPS; interferon-gamma, IFN-gamma) was further potentiated with hypoxic (5% O2) conditions.	Oxygen	131-133	interferon gamma	Homo sapiens	79-88
26398547-6	2015	Cultured rat aortic VSMCs treated with Ang II (1 microM) for 24 h exhibited mitochondrial dysfunction, including a decrease in mitochondrial oxygen consumption rates (OCRs), adenosine triphosphate (ATP) production and mitochondrial DNA (mtDNA) levels, as well as the disruption of mitochondrial structural integrity.	Oxygen	141-147	angiotensinogen	Rattus norvegicus	39-45
26263212-7	2015	We hypothesize that the EDF characteristics of the synthesized PLM may be attributed to the presence of n-pi* interactions of the hydroxyl oxygen atoms of PEG with carbonyl groups of the ester linkages.	Oxygen	139-145	FXYD domain containing ion transport regulator 1	Homo sapiens	63-66
26258821-0	2015	Antioxidants may Attenuate Plasma Erythropoietin Decline after Hyperbaric Oxygen Diving.	Oxygen	74-80	erythropoietin	Homo sapiens	34-48
26258821-1	2015	According to previous studies, plasma erythropoietin (EPO) may decrease after hyperbaric oxygen exposure due to oxidative stress.	Oxygen	89-95	erythropoietin	Homo sapiens	38-52
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	190-196	superoxide dismutase 1	Homo sapiens	41-44
26258821-1	2015	According to previous studies, plasma erythropoietin (EPO) may decrease after hyperbaric oxygen exposure due to oxidative stress.	Oxygen	89-95	erythropoietin	Homo sapiens	54-57
26258821-2	2015	It is hypothesized that the decrease of EPO can be attenuated by oxygen free radical scavengers.The aim of the present study was to evaluate whether EPO plasma levels can be influenced by oral application of vitamin C and E before repeated hyperbaric oxygen exposure during diving.	Oxygen	65-71	erythropoietin	Homo sapiens	149-152
26258821-8	2015	Radical scavenging vitamins C and D may counteract hyperbaric oxygen related mechanisms reducing EPO production in hyperbaric oxygen exposure during diving.	Oxygen	62-68	erythropoietin	Homo sapiens	97-100
26258821-8	2015	Radical scavenging vitamins C and D may counteract hyperbaric oxygen related mechanisms reducing EPO production in hyperbaric oxygen exposure during diving.	Oxygen	126-132	erythropoietin	Homo sapiens	97-100
26374996-8	2015	Mitochondria of SOD2-tg mice had a decreased state 3 oxygen consumption rate, but maintained the same ATP production flux under the basal and L-NAME treatment conditions, indicating a higher bioenergetic efficiency.	Oxygen	53-59	superoxide dismutase 2, mitochondrial	Mus musculus	16-20
25940780-6	2015	Results demonstrate a synergistic effect of oxygen concentration and 1% ZnONP in up-regulation of anabolic gene expression (Type II collagen and aggrecan), and a down regulation of catabolic (MMP-13) gene expression.	Oxygen	44-50	matrix metallopeptidase 13	Bos taurus	192-198
26206760-4	2015	Furthermore, abundant oxygen in vivo inhibits the activation of HIF-1 and potentially blockades kinds of HIF-1-induced oncogenic signaling pathways.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
26206760-4	2015	Furthermore, abundant oxygen in vivo inhibits the activation of HIF-1 and potentially blockades kinds of HIF-1-induced oncogenic signaling pathways.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	190-196	superoxide dismutase 1	Homo sapiens	57-61
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	220-226	superoxide dismutase 1	Homo sapiens	41-44
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	220-226	superoxide dismutase 1	Homo sapiens	57-61
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	220-226	superoxide dismutase 1	Homo sapiens	41-44
26203919-5	2015	The short-term exposure of SCAP to glucose/oxygen deprivation (GOD) in the presence, but mainly in deprivation, of serum (SGOD) elicited a proangiogenesis effect indicated by expression of angiogenesis-related genes involved in vascular endothelial growth factor (VEGF)/VEGFR and angiopoietins/Tie pathways.	Oxygen	43-49	vascular endothelial growth factor A	Homo sapiens	228-262
26203919-5	2015	The short-term exposure of SCAP to glucose/oxygen deprivation (GOD) in the presence, but mainly in deprivation, of serum (SGOD) elicited a proangiogenesis effect indicated by expression of angiogenesis-related genes involved in vascular endothelial growth factor (VEGF)/VEGFR and angiopoietins/Tie pathways.	Oxygen	43-49	vascular endothelial growth factor A	Homo sapiens	264-268
26637092-5	2015	AIM: The aim of study was to evaluate of SOD isoenzymes (SOD1 and SOD2) expression level in cell lines of primary (SW 480) and metastatic (SW 620) colorectal cancer, cultured in hypoxia (1% oxygen), tissue normoxia (10% oxygen), and atmospheric normoxia (21% oxygen).	Oxygen	220-226	superoxide dismutase 1	Homo sapiens	57-61
26637092-15	2015	CONCLUSIONS: The profile of expression of SOD1 and SOD2 in cell lines SW480 and SW620 indicates differentiated response of tumor cells depending on access to oxygen.	Oxygen	158-164	superoxide dismutase 1	Homo sapiens	42-46
26013839-4	2015	RESULTS: The addition of IL-6 to HRMCs exposed to 20% O2 did not significantly impact either the CFCs or in vivo short-term repopulating cells.	Oxygen	54-56	interleukin 6	Mus musculus	25-29
26637092-17	2015	Differences of SOD isoenzymes expression level in tissue normoxia indicate their compensatory action, allowing to maintain the balance between O2- removal and H2O2production in studied tumor cells.	Oxygen	143-145	superoxide dismutase 1	Homo sapiens	15-18
26013839-6	2015	The exposure of HRMCs to 5% O2 negatively affected the amplification of CFCs, which was not changed by the addition of IL-6 and exhibited a partial enhancing effect on the long-term repopulating cells.	Oxygen	28-30	interleukin 6	Mus musculus	119-123
26013839-7	2015	CONCLUSION: The addition of IL-6 to the cytokine cocktail further improves our expansion procedure based on atmospheric O2 concentration-exposed HRMCs by enhancing the maintenance of the most primitive HSCs without a negative impact on the less primitive HSC populations and CFCs.	Oxygen	120-122	interleukin 6	Mus musculus	28-32
29124218-1	2015	Protoporphyrinogen oxidase (PPOX), the penultimate enzyme in the haem biosynthetic pathway catalysers the six electron oxidation of protoporphyrinogen-IX to protoporphyrin-IX, in the presence of flavin adenine dinucleotide (FAD) and oxygen.	Oxygen	233-239	protoporphyrinogen oxidase	Homo sapiens	28-32
26512962-7	2015	This evidence suggests that both potassium efflux and calcium influx are necessary for mitochondrial reactive oxygen generation upstream of NLRP3 inflammasome assembly and pyroptotic cell death.	Oxygen	110-116	NLR family pyrin domain containing 3	Homo sapiens	140-145
26512962-8	2015	We propose a model wherein potassium efflux is necessary for calcium influx, resulting in mitochondrial reactive oxygen generation to trigger the NLRP3 inflammasome.	Oxygen	113-119	NLR family pyrin domain containing 3	Homo sapiens	146-151
26308144-1	2015	Superoxide dismutase (SOD) is a 32 kDa dimeric enzyme that actively removes a toxic oxygen species within red cells.	Oxygen	84-90	superoxide dismutase 1	Homo sapiens	0-20
26308144-1	2015	Superoxide dismutase (SOD) is a 32 kDa dimeric enzyme that actively removes a toxic oxygen species within red cells.	Oxygen	84-90	superoxide dismutase 1	Homo sapiens	22-25
26416428-9	2015	Levels of phosphorylated Akt, anti-apoptotic Bcl-xL, pro-apoptotic Bax and endothelial nitric oxide synthase (NOS) were re-regulated after combined oxygen and melatonin delivery, whereas neuronal and inducible NOS, which were increased by oxygen treatment, were not influenced by melatonin.	Oxygen	148-154	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
26503783-5	2015	Despite substantial decreases in mitochondrial thermogenic proteins in brown fat, mice lacking YY1 in this tissue are strongly protected against diet-induced obesity and exhibit increased energy expenditure and oxygen consumption in beige and white fat depots.	Oxygen	211-217	YY1 transcription factor	Mus musculus	95-98
26419907-3	2015	Upon the stimuli by CA generated from ALP, the inert TiO2 NPs is activated, which demonstrates highly efficient oxidase mimicking activity for catalyzing the oxidation of the typical substrate of 3,3",5,5"-tetramethylbenzidine (TMB) under visible light (lambda &gt;= 400 nm) irradiation utilizing dissolved oxygen as an electron acceptor.	Oxygen	307-313	alkaline phosphatase, placental	Homo sapiens	38-41
26469226-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that triggers adaptive responses upon low oxygen conditions and plays a crucial role in cancer metabolism and therapy resistance.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26469226-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that triggers adaptive responses upon low oxygen conditions and plays a crucial role in cancer metabolism and therapy resistance.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
26469226-4	2015	TM-mediated HIF-1alpha downregulation was suppressed when HIF-prolyl hydroxylase activity was pharmacologically inhibited using deferoxamine or dimethyloxaloylglycine, and also when the oxygen-dependent degradation domains of HIF-1alpha, which are responsible for the interaction with HIF-prolyl hydroxylase, were deleted.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
26475712-6	2015	In vitro, we found that MSC co-culture downregulated TLR2/NFkappaB signaling and repressed Bax expression and IL-10 secretion in oxygen and glucose deprivation (OGD)-injured adrenal pheochromocytoma (PC12) cells.	Oxygen	129-135	musculin	Rattus norvegicus	24-27
26416428-9	2015	Levels of phosphorylated Akt, anti-apoptotic Bcl-xL, pro-apoptotic Bax and endothelial nitric oxide synthase (NOS) were re-regulated after combined oxygen and melatonin delivery, whereas neuronal and inducible NOS, which were increased by oxygen treatment, were not influenced by melatonin.	Oxygen	148-154	nitric oxide synthase 3	Homo sapiens	75-108
26335043-5	2015	Significant oxidation of pyrite was measured at pH 0 with a yield of 100 muM Fe(III) after 5 mM pyrite was incubated with 2000 muM nitrite for 24 h. Dissolved oxygen increased the rate at pH 0.	Oxygen	159-165	latexin	Homo sapiens	73-76
26335043-5	2015	Significant oxidation of pyrite was measured at pH 0 with a yield of 100 muM Fe(III) after 5 mM pyrite was incubated with 2000 muM nitrite for 24 h. Dissolved oxygen increased the rate at pH 0.	Oxygen	159-165	latexin	Homo sapiens	127-130
26384744-8	2015	Moreover, unlike previous studies, the sulfoxidation is preferred through a beta-oxygen atom transfer from the Ti hydroperoxo group because the alpha-oxygen atom transfer leads to an unfavourable seven-fold coordinated Ti environment in the transition state.	Oxygen	81-87	amyloid beta precursor protein	Homo sapiens	74-80
26384744-8	2015	Moreover, unlike previous studies, the sulfoxidation is preferred through a beta-oxygen atom transfer from the Ti hydroperoxo group because the alpha-oxygen atom transfer leads to an unfavourable seven-fold coordinated Ti environment in the transition state.	Oxygen	150-156	amyloid beta precursor protein	Homo sapiens	74-80
26254336-6	2015	Interestingly, although mitochondrial ROS emission is reduced in the ErbB2(tg) hearts, oxygen consumption rates and complex I activity are similar to control littermates.	Oxygen	87-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-78
26291542-10	2015	Peak oxygen uptake increased 1.1 (0.4-1.7) ml min(-1) kg(-1) (8%) from baseline (P&lt;0.01).	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	46-52
26190797-5	2015	Zn-Por moieties in SNG keep the photosensitivity in the range of visible wavelength and possess the ability of generating active oxygen species for photodynamic therapy.	Oxygen	129-135	cytochrome p450 oxidoreductase	Homo sapiens	3-6
26096044-2	2015	Haplotype A is very similar to the goat beta-globin locus, whereas haplotype B has a deletion spanning four globin genes, including beta-C globin, which encodes a globin with high oxygen affinity.	Oxygen	180-186	hemoglobin subunit beta-C	Capra hircus	132-145
31973389-2	2015	Preliminary studies show that, among the four platinum(II) complexes, Pt3 is an efficient catalyst for CDC reactions with oxygen as an oxidant.	Oxygen	122-128	zinc finger protein 135	Homo sapiens	70-73
26112987-8	2015	However, 50% O2 increased expression of Epac2, which is activated by cAMP and can regulate protein secretion.	Oxygen	13-15	Rap guanine nucleotide exchange factor 4	Homo sapiens	40-45
26483619-3	2015	Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of immediate adaptation to hypoxia necessary for (1) succinate-related energy synthesis in the conditions of oxygen deficiency and formation of urgent resistance in the body; (2) succinate-related stabilization of HIF-1alpha and initiation of its transcriptional activity related with formation of long-term adaptation; (3) succinate-related activation of the succinate-specific receptor, GPR91.	Oxygen	209-215	hypoxia inducible factor 1 subunit alpha	Homo sapiens	314-324
26306982-4	2015	Furthermore, the introduction of an oxygen atom in the hydrocarbon scaffold of adamantane is deleterious to 11beta-HSD1 inhibition.	Oxygen	36-42	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	108-119
26194913-6	2015	Sema3C administration strongly inhibited the formation of pathological pre-retinal vascular tufts during oxygen-induced retinopathy.	Oxygen	105-111	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	Mus musculus	0-6
26117330-1	2015	Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen.	Oxygen	103-109	catalase	Homo sapiens	0-8
26483636-4	2015	Overexpression of active BACE1, but not a protease-dead mutant BACE1, protein in SH-SY5Y cells reduced glucose oxidation and the basal oxygen consumption rate, which was associated with a compensatory increase in glycolysis.	Oxygen	135-141	beta-secretase 1	Homo sapiens	25-30
25808624-9	2015	RUNX2 also repressed mitochondrial oxygen consumption rates (OCR), a measure of oxidative phosphorylation (respiration).	Oxygen	35-41	RUNX family transcription factor 2	Homo sapiens	0-5
25892255-4	2015	We found that an oxygen concentration exceeding 3 muM is required for formation and maintenance of microcolonies.	Oxygen	17-23	latexin	Homo sapiens	50-53
26211916-3	2015	While the 20-fold higher oxygen affinity of Lba compared with Mb is required for its dual physiological function, the mechanism by which this high affinity is achieved is only emerging.	Oxygen	25-31	leghemoglobin A	Glycine max	44-47
26269525-2	2015	mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.	Oxygen	206-212	mechanistic target of rapamycin kinase	Homo sapiens	0-4
23596131-5	2015	2% O(2) resulted in a significantly lower CD34(+) cell expansion (25-fold vs 60-, 64- and 92-fold at day 10 for 5%, 21%, 10% O(2), respectively).	Oxygen	3-7	CD34 molecule	Homo sapiens	42-46
23596131-6	2015	In turn, 10% O(2) promoted the highest CD34(+) CD90(+) cell expansion, reaching 22 +- 5.4- vs 5.6 +- 2.4- and 5.7 +- 2.0-fold for 2%, 5% and 21% O(2), respectively, after 14 days.	Oxygen	13-17	CD34 molecule	Homo sapiens	39-43
26066786-1	2015	HIF-1 is the master regulator of cellular hypoxia response; the oxygen sensitive HIF-1alpha subunit transactivates its own expression in hypoxia via a hypoxia response element (HRE) in the promoter of the HIF-1alpha gene.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
26066786-1	2015	HIF-1 is the master regulator of cellular hypoxia response; the oxygen sensitive HIF-1alpha subunit transactivates its own expression in hypoxia via a hypoxia response element (HRE) in the promoter of the HIF-1alpha gene.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
26066786-1	2015	HIF-1 is the master regulator of cellular hypoxia response; the oxygen sensitive HIF-1alpha subunit transactivates its own expression in hypoxia via a hypoxia response element (HRE) in the promoter of the HIF-1alpha gene.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	205-215
26779382-3	2015	Earlier we observed that OM-mediated aryl hydrocarbon receptor (AhR) activation attenuates acute hyperoxic lung injury in adult mice and oxygen toxicity in adult human lung cells.	Oxygen	137-143	aryl-hydrocarbon receptor	Mus musculus	64-67
26360882-6	2015	We demonstrate enhanced transcription of the gene VEGFA (vascular endothelial growth factor A) with decreasing oxygen levels in human lung adenocarcinoma cells.	Oxygen	111-117	vascular endothelial growth factor A	Homo sapiens	50-55
26159831-4	2015	In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.	Oxygen	38-44	transcription factor A, mitochondrial	Homo sapiens	155-159
26413894-3	2015	We have determined the K0.5(Ca2+) of the external NADPH dehydrogenase from Solanum tuberosum mitochondria and membranes of E. coli expressing Arabidopsis thaliana NDB1 over the physiological pH range using O2 and decylubiquinone as electron acceptors.	Oxygen	206-208	NAD(P)H dehydrogenase B1	Arabidopsis thaliana	163-167
26252621-14	2015	Synthetic analogues of heme, offering a hydrophobic distal environment, have been used to trap oxygen bound intermediates, which provides insight into the mechanism of PROS generation by reduced heme-Abeta.	Oxygen	95-101	amyloid beta precursor protein	Homo sapiens	200-205
26366999-0	2015	IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway.	Oxygen	27-33	AKT serine/threonine kinase 1	Homo sapiens	85-88
26366999-7	2015	These findings suggest that IL-10 provides neuroprotective effects by protecting neurites through PI3K/AKT signaling pathway in oxygen-glucose-deprived primary cortical neurons.	Oxygen	128-134	AKT serine/threonine kinase 1	Homo sapiens	103-106
26270157-6	2015	We show that Zn CPF interacts with (1)O2 mainly by physical quenching using a combination of (1)O2 luminescence quenching and kinetic competition experiments.	Oxygen	35-40	nuclear receptor subfamily 5 group A member 2	Homo sapiens	16-19
26270157-6	2015	We show that Zn CPF interacts with (1)O2 mainly by physical quenching using a combination of (1)O2 luminescence quenching and kinetic competition experiments.	Oxygen	93-98	nuclear receptor subfamily 5 group A member 2	Homo sapiens	16-19
26236034-4	2015	In contrast to the formation of 1-3, the use of N-methyldiethanolamine (L) in the reaction with Ce(NO3 )3  6 H2 O and pivalic acid afforded a previously reported Ce(III) dinuclear cluster, Ce2 (O2 CtBu)6 L2 , even in the presence of dioxygen.	Oxygen	233-241	carboxylesterase 2	Homo sapiens	189-192
26360882-6	2015	We demonstrate enhanced transcription of the gene VEGFA (vascular endothelial growth factor A) with decreasing oxygen levels in human lung adenocarcinoma cells.	Oxygen	111-117	vascular endothelial growth factor A	Homo sapiens	57-93
26347290-0	2015	Reverse Catalase Reaction: Dioxygen Activation via Two-Electron Transfer from Hydroxide to Dioxygen Mediated By a Manganese(III) Salen Complex.	Oxygen	27-35	catalase	Homo sapiens	8-16
26347290-0	2015	Reverse Catalase Reaction: Dioxygen Activation via Two-Electron Transfer from Hydroxide to Dioxygen Mediated By a Manganese(III) Salen Complex.	Oxygen	91-99	catalase	Homo sapiens	8-16
26347290-7	2015	The conversion of both O2 and OH(-) to a peroxide species is exactly the reverse of a catalase-like reaction, which has a great potential as the most efficient O2 activation.	Oxygen	23-25	catalase	Homo sapiens	86-94
26347290-7	2015	The conversion of both O2 and OH(-) to a peroxide species is exactly the reverse of a catalase-like reaction, which has a great potential as the most efficient O2 activation.	Oxygen	160-162	catalase	Homo sapiens	86-94
26205818-8	2015	By the same reasoning, dioxygenase inhibition by FQ was predicted to stabilize transcription factor HIF-1alpha by inhibition of the oxygen-dependent hypoxia-inducible transcription factor prolyl hydroxylation.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
26211519-2	2015	It is found that in the presence of p53, the strong interaction between the wild-type p53 and its consensus DNA sequence on the electrode surface can block the electron transfer from the BOD to the electrode, thus providing a good opportunity for reducing the electrocatalytic activity of oxygen reduction in the biocathode.	Oxygen	289-295	tumor protein p53	Homo sapiens	36-39
26211519-2	2015	It is found that in the presence of p53, the strong interaction between the wild-type p53 and its consensus DNA sequence on the electrode surface can block the electron transfer from the BOD to the electrode, thus providing a good opportunity for reducing the electrocatalytic activity of oxygen reduction in the biocathode.	Oxygen	289-295	tumor protein p53	Homo sapiens	86-89
26113285-1	2015	AIM: Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of series of genes and the primary factor mediating this response is the hypoxia-inducible factor-1alpha.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	181-212
26138643-4	2015	Results indicated that inflammation (IL-6 levels) and oxidation (F2a-isoprostanes) persisted through 8 wk of life in mice exposed to LPS/O2 perinatally.	Oxygen	137-139	interleukin 6	Mus musculus	37-41
26138643-4	2015	Results indicated that inflammation (IL-6 levels) and oxidation (F2a-isoprostanes) persisted through 8 wk of life in mice exposed to LPS/O2 perinatally.	Oxygen	137-139	toll-like receptor 4	Mus musculus	133-136
26138645-8	2015	At P7d, HO-1 gene expression was greater in the 65% O2 group than in the 21% O2 group.	Oxygen	52-54	heme oxygenase 1	Mus musculus	8-12
26138645-8	2015	At P7d, HO-1 gene expression was greater in the 65% O2 group than in the 21% O2 group.	Oxygen	77-79	heme oxygenase 1	Mus musculus	8-12
26187473-2	2015	At physiological oxygen concentration, PHDs drive the degradation of the HIF-1alpha (hypoxia-inducible factor 1-alpha), which is responsible for upregulating the expression of genes involved in the cellular response to hypoxia.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
26187473-2	2015	At physiological oxygen concentration, PHDs drive the degradation of the HIF-1alpha (hypoxia-inducible factor 1-alpha), which is responsible for upregulating the expression of genes involved in the cellular response to hypoxia.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-117
26235421-2	2015	In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased oxygen consumption and energy expenditure.	Oxygen	171-177	G protein-coupled bile acid receptor 1	Homo sapiens	142-146
26269505-11	2015	The Prl3d1 gene is expressed by trophoblast giant cells both in the labyrinth layer, sitting on the arterial side where maternal blood is highest in oxygen and nutrients, and in the junctional zone as maternal blood leaves the placenta.	Oxygen	149-155	prolactin family 3, subfamily d, member 1	Mus musculus	4-10
26137956-2	2015	Myeloperoxidase is a reactive oxygen generating enzyme and is expressed by microglia.	Oxygen	30-36	myeloperoxidase	Homo sapiens	0-15
26417446-11	2015	Elucidating the effect of hyperoxia on ovalbumin-induced acute airway inflammation is relevant to preventing or treating asthmatic patients that require oxygen supplementation to reverse the hypoxemia.	Oxygen	153-159	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	39-48
26024859-10	2015	Our data suggest LDH as a direct PrP(c) interactor with possible physiological relevance under low oxygen conditions.	Oxygen	99-105	prion protein	Homo sapiens	33-39
26617752-13	2015	ATRA decreased anti-oxygen protein Nrf2 and HO-1, and increases inflammatory factors NF-kappaB and TNF-alpha.	Oxygen	20-26	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
26116387-2	2015	Catalase, an important antioxidant enzyme, catalyzing decomposition of hydrogen peroxide to water and molecular oxygen, hampers in vitro HOCl formation, but is also one of the main targets for HOCl.	Oxygen	112-118	catalase	Homo sapiens	0-8
26113536-2	2015	HF-fed Pemt(-/-) mice show higher oxygen consumption and heat production, indicating that more energy might be utilized for thermogenesis and might account for the resistance to diet-induced weight gain.	Oxygen	34-40	phosphatidylethanolamine N-methyltransferase	Mus musculus	7-11
26289278-2	2015	The O2 gas was made from the reaction between H2O2 and catalase.	Oxygen	4-6	catalase	Mus musculus	46-63
26111938-12	2015	Supplementation of BH4 or activation of PPARdelta prevents detrimental effects of eNOS uncoupling by restoring bioavailability of BH4 and scavenging of .O2(-), respectively (b).	Oxygen	153-155	peroxisome proliferator activator receptor delta	Mus musculus	40-49
25825812-1	2015	BACKGROUND: The aim of the present study was to investigate the association of fMRI blood oxygen-level dependent (BOLD) reactivity with the level of epigenetic methylation of SLC6A4 in blood DNA from a sample of healthy participants and patients with major depressive disorder (MDD).	Oxygen	90-96	solute carrier family 6 member 4	Homo sapiens	175-181
26048361-11	2015	We found decreased Akt phosphorylation in Eker but not Long-Evans rat brains, suggesting that this may be related to the increased cerebral O2 consumption in the Eker rat.	Oxygen	140-142	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
26297648-2	2015	The quinol oxidase (Cyo) encoded by cyoABCD is needed for efficient adaptation to low oxygen conditions and cyo transcription is upregulated at low oxygen.	Oxygen	86-92	DoxX family protein	Rhizobium etli CFN 42	4-18
26297648-2	2015	The quinol oxidase (Cyo) encoded by cyoABCD is needed for efficient adaptation to low oxygen conditions and cyo transcription is upregulated at low oxygen.	Oxygen	148-154	DoxX family protein	Rhizobium etli CFN 42	4-18
26426613-10	2015	Levels of IL-6, IL-1beta, and IL-8 detected in NPA from RSV single and associated to HRV were significantly higher than HRV infected and positively associated with days requiring O2.Levels of IL-6, IL-1beta, and IL-8 detected in NPA from patients infected with RSV only or with both RSV and HRV are increased, and any of those 3 cytokines may have a predictive value for the number of days with need of supplemental oxygen.	Oxygen	179-181	interleukin 6	Homo sapiens	10-14
26426613-10	2015	Levels of IL-6, IL-1beta, and IL-8 detected in NPA from RSV single and associated to HRV were significantly higher than HRV infected and positively associated with days requiring O2.Levels of IL-6, IL-1beta, and IL-8 detected in NPA from patients infected with RSV only or with both RSV and HRV are increased, and any of those 3 cytokines may have a predictive value for the number of days with need of supplemental oxygen.	Oxygen	179-181	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
26392741-11	2015	CONCLUSIONS: Recently, we reported that nuclear beta-catenin, but not HIF-2alpha, regulates the expression of fibronectin and alpha-SMA in atmospheric oxygen.	Oxygen	151-157	fibronectin 1	Homo sapiens	110-121
26291737-4	2015	Here, we demonstrate that the aminopeptidase inhibitor, CHR-2797/tosedostat, increases the radiosensitivity of esophageal cancer cell lines (FLO-1 and OE21) in vitro in both normoxic and physiologically relevant low oxygen conditions.	Oxygen	216-222	carboxypeptidase Q	Homo sapiens	30-44
26827533-8	2015	CONCLUSION: Low oxygen reduced Kv1.5 mRNA and protein expressions, U0126 could resistant the Kv1.5 channel lower expression caused by hypoxia.	Oxygen	16-22	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	31-36
26298789-9	2015	Moreover, the TNFalpha concentration was significantly correlated with the percentage of nighttime spent with oxygen saturation less than 90%.	Oxygen	110-116	tumor necrosis factor	Homo sapiens	14-22
26323635-4	2015	Here, using synchrotron x-ray diffraction in laser-heated diamond anvil cells, we show that MgO and oxygen react at pressures above 96 GPa and T = 2150 K with the formation of I4/mcm MgO2.	Oxygen	100-106	PPP1R2C family member C	Homo sapiens	176-187
26827528-9	2015	But the total BALF protein level and the inflammatory cytokine TNF-alpha expression of 1 ATA oxygen pre-breathe group were obviously decreased, while the dry/wet ratio of lung as obviously increased instead (P &lt; 0.05).	Oxygen	93-99	tumor necrosis factor	Rattus norvegicus	63-72
26827533-9	2015	Anisomycin had no significant effect on Kv1.5 channel expression under hypoxia, but the expression of Kv1.5 was still significantly lower than the normal oxygen group.	Oxygen	154-160	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	102-107
26179900-2	2015	When O2 availability decreases, the transcription factor hypoxia-inducible factor (HIF)-1alpha is stabilized and regulates cellular adaptation to hypoxia.	Oxygen	5-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-94
26315260-5	2015	At even higher pressure, the close-packed structure of the oxygen sublattice becomes unstable to a new unusual superionic phase in which the oxygen sublattice takes the P2(1)/c symmetry.	Oxygen	141-147	cyclin dependent kinase inhibitor 1A	Homo sapiens	169-174
26339320-10	2015	We also observed that cells move faster towards high concentrations of chemoattractant when the oxygen tension is below 3% due to the increased expression of HIF-1 (hypoxia-inducible factor 1), which promotes a transition to the amoeboid rather than mesenchymal mode of movement.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-163
26339320-10	2015	We also observed that cells move faster towards high concentrations of chemoattractant when the oxygen tension is below 3% due to the increased expression of HIF-1 (hypoxia-inducible factor 1), which promotes a transition to the amoeboid rather than mesenchymal mode of movement.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	165-191
26009875-10	2015	Low oxygen tension inhibits the function of Jarid1A, leading to increased presence of H3K4me3 within the CEMIP promoter.	Oxygen	4-10	cell migration inducing hyaluronidase 1	Homo sapiens	105-110
26196462-2	2015	A notable feature of this enzyme complex is that it uses menaquinol as its electron donor instead of cytochrome c when it reduces dioxygen to water.	Oxygen	130-138	cytochrome c, somatic	Homo sapiens	101-113
26286023-1	2015	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease.	Oxygen	94-100	nitric oxide synthase 3	Homo sapiens	0-33
26286023-1	2015	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease.	Oxygen	94-100	nitric oxide synthase 3	Homo sapiens	35-39
26293784-2	2015	HIF-1 alpha regulates oxygen homeostasis in hypoxic tissues such as joint cartilage; efficiency of transcriptional activity of the HIF1A gene is strongly influenced by the presence of polymorphic variants.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
26293784-2	2015	HIF-1 alpha regulates oxygen homeostasis in hypoxic tissues such as joint cartilage; efficiency of transcriptional activity of the HIF1A gene is strongly influenced by the presence of polymorphic variants.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-136
26274907-8	2015	Consistent with its relatively high in vitro activity, crystallographic studies suggest that absence in Hybrid-2 of an ether oxygen of the C2-ethoxymethyl substituent, which can engage in unfavorable electrostatic and/or dipolar interactions with the carbonyl oxygen of Gly572 in human TLR8, may confer greater efficacy and potency compared to R848.	Oxygen	125-131	toll like receptor 8	Homo sapiens	286-290
26274907-8	2015	Consistent with its relatively high in vitro activity, crystallographic studies suggest that absence in Hybrid-2 of an ether oxygen of the C2-ethoxymethyl substituent, which can engage in unfavorable electrostatic and/or dipolar interactions with the carbonyl oxygen of Gly572 in human TLR8, may confer greater efficacy and potency compared to R848.	Oxygen	260-266	toll like receptor 8	Homo sapiens	286-290
26574473-2	2015	The binding of the von Hippel-Lindau tumor suppressor protein (pVHL)-ElonginC-ElonginB complex (VCB) to HIF-1alpha is highly selective for the trans-4-hydroxylation form of when Pro564 in the C-terminal oxygen-dependent degradation domain (ODDD) of HIF-1alpha.	Oxygen	203-209	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
26235614-0	2015	The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.	Oxygen	16-22	egl-9 family hypoxia inducible factor 1	Homo sapiens	30-34
26235614-1	2015	Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed.	Oxygen	40-46	egl-9 family hypoxia inducible factor 1	Homo sapiens	54-74
26235614-1	2015	Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed.	Oxygen	40-46	egl-9 family hypoxia inducible factor 1	Homo sapiens	76-80
26574473-2	2015	The binding of the von Hippel-Lindau tumor suppressor protein (pVHL)-ElonginC-ElonginB complex (VCB) to HIF-1alpha is highly selective for the trans-4-hydroxylation form of when Pro564 in the C-terminal oxygen-dependent degradation domain (ODDD) of HIF-1alpha.	Oxygen	203-209	hypoxia inducible factor 1 subunit alpha	Homo sapiens	249-259
26037477-6	2015	Exposure of primary isolated trophoblast cells, human villous explants, and JEG3 choriocarcinoma cells to low oxygen (3%) and sodium nitroprusside (inducer of oxidative stress) also resulted in elevated JMJD6 levels, which was abrogated by HIF1A knockdown.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	240-245
25314640-1	2015	AIMS: Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures.	Oxygen	144-150	aldehyde oxidase 1	Homo sapiens	75-91
25929785-5	2015	Hypoxia (1% O2) did not modify cytotoxicity, but decreasing O2 tensions during CTL and CD8(+) tumor-infiltrating lymphocyte reactivation dose-dependently decreased proliferation, induced secretion of the immunosuppressive cytokine IL-10, and upregulated the expression of CD137 (4-1BB) and CD25.	Oxygen	60-62	interleukin 10	Mus musculus	231-236
25929785-5	2015	Hypoxia (1% O2) did not modify cytotoxicity, but decreasing O2 tensions during CTL and CD8(+) tumor-infiltrating lymphocyte reactivation dose-dependently decreased proliferation, induced secretion of the immunosuppressive cytokine IL-10, and upregulated the expression of CD137 (4-1BB) and CD25.	Oxygen	60-62	tumor necrosis factor receptor superfamily, member 9	Mus musculus	272-277
26112411-5	2015	PHD2, the most important human PHD isoform, is proposed to be biochemically/kinetically suited as a hypoxia sensor due to its relatively high sensitivity to changes in O2 concentration and slow reaction with O2.	Oxygen	168-170	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
26112411-5	2015	PHD2, the most important human PHD isoform, is proposed to be biochemically/kinetically suited as a hypoxia sensor due to its relatively high sensitivity to changes in O2 concentration and slow reaction with O2.	Oxygen	208-210	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
26112411-6	2015	To ascertain whether these parameters are conserved among the HIF hydroxylases, we compared the reactions of FIH and PHD2 with O2.	Oxygen	127-129	egl-9 family hypoxia inducible factor 1	Homo sapiens	117-121
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	79-81	interleukin 6	Homo sapiens	33-37
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	79-81	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	123-125	interleukin 6	Homo sapiens	33-37
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	123-125	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
26037477-10	2015	In summary, our data signify a novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-133
25946602-10	2015	VEGF was secreted more during hypoxia (0.1% oxygen) than during normoxia (21% oxygen).	Oxygen	44-50	vascular endothelial growth factor A	Homo sapiens	0-4
25862413-1	2015	Oxygen-derived free radicals (ROS) have been identified to contribute significantly to ischemia-reperfusion (I/R) injury by initiating chain reactions with polyunsaturated membrane lipids (lipid peroxidation, LPO) resulting in the generation of several aldehydes and ketones.	Oxygen	0-6	lactoperoxidase	Homo sapiens	209-212
26007236-7	2015	At hypoxia (5% O2), IDH2-related and unrelated (13)C-accumulation into citrate and malate increased 1.5-2.5-fold with unchanged IDH2 expression; whereas hypoxic 2HG formation did not.	Oxygen	15-17	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
26095976-7	2015	Exposure of AMCs to chronic hypoxia (2% O2; 48 h) in vitro caused a significant increase to TrkB mRNA expression.	Oxygen	40-42	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	92-96
26095976-9	2015	A specific TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), stimulated quantal catecholamine secretion from chronically hypoxic (CHox; 2% O2) AMCs to a greater extent than normoxic (Nox; 21% O2) controls.	Oxygen	135-137	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	11-15
26095976-9	2015	A specific TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), stimulated quantal catecholamine secretion from chronically hypoxic (CHox; 2% O2) AMCs to a greater extent than normoxic (Nox; 21% O2) controls.	Oxygen	188-190	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	11-15
25995437-0	2015	The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1alpha Phosphorylation.	Oxygen	31-37	AKT serine/threonine kinase 1	Homo sapiens	9-12
25995437-0	2015	The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1alpha Phosphorylation.	Oxygen	31-37	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	77-80
25995437-5	2015	Pharmacologic inhibition of the PI3K/mTOR pathway or genetic inhibition of Akt/PI3K decreased the oxygen consumption rate (OCR) in vitro in SQ20B and other cell lines by 30% to 40%.	Oxygen	98-104	AKT serine/threonine kinase 1	Homo sapiens	75-78
25995437-10	2015	Our findings highlight an association between the PI3K/mTOR pathway and tumor cell oxygen consumption that is regulated in part by PDH phosphorylation.	Oxygen	83-89	mechanistic target of rapamycin kinase	Homo sapiens	55-59
25995437-10	2015	Our findings highlight an association between the PI3K/mTOR pathway and tumor cell oxygen consumption that is regulated in part by PDH phosphorylation.	Oxygen	83-89	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	131-134
26272735-5	2015	The current study aimed to evaluate the effect of inhibiting the main enzyme involved in cGMP degradation, phosphodiesterase 5 (PDE5), on blood flow and O2 delivery in contracting skeletal muscle of young and older humans.	Oxygen	153-155	phosphodiesterase 5A	Homo sapiens	107-126
26272735-5	2015	The current study aimed to evaluate the effect of inhibiting the main enzyme involved in cGMP degradation, phosphodiesterase 5 (PDE5), on blood flow and O2 delivery in contracting skeletal muscle of young and older humans.	Oxygen	153-155	phosphodiesterase 5A	Homo sapiens	128-132
25881547-6	2015	SIN-1 simultaneously releases ( )NO and O2( -), which react to form ONOO(H), but exposure of the three strains separately to an ( )NO donor (spermine-NONOate) or an O2( -) generator (paraquat) mainly depresses catalase or Prx activity, whereas co-challenge with the NONOate and paraquat stimulates these activities.	Oxygen	40-42	MAPK associated protein 1	Homo sapiens	0-5
25982374-1	2015	BACKGROUND: The neuroprotective mechanisms of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) remain unclear, especially neuronal apoptosis associations such as the expression of tumor necrosis factor alpha (TNF-alpha), transforming growth-interacting factor (TGIF), and TGF-beta1 after TBI.	Oxygen	57-63	tumor necrosis factor	Rattus norvegicus	195-222
26095815-0	2015	Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women.	Oxygen	84-90	Rho GTPase activating protein 45	Homo sapiens	30-67
26095815-8	2015	HA-1 mRNA was increased in cobalt chloride-treated placental explants and purified cytotrophoblast cells (P = 0.04 and P&lt;0.01, respectively) and in purified cytotrophoblast cells cultured under 2% as compared to 8% and 21% oxygen (P&lt;0.01).	Oxygen	226-232	Rho GTPase activating protein 45	Homo sapiens	0-4
26095815-11	2015	DISCUSSION: Placental HA-1 expression is regulated by oxygen and is increased in the syncytial nuclear aggregates and syncytiotrophoblast of preeclamptic as compared to control placentas.	Oxygen	54-60	Rho GTPase activating protein 45	Homo sapiens	22-26
25946602-10	2015	VEGF was secreted more during hypoxia (0.1% oxygen) than during normoxia (21% oxygen).	Oxygen	78-84	vascular endothelial growth factor A	Homo sapiens	0-4
28162290-7	2015	Inhibition of mitochondrial respiration by low concentrations of NO at critical O2 concentrations also leads to prevention of the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) due to the redistribution of O2 towards non-respiratory O2-dependent targets.	Oxygen	221-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-178
28162290-7	2015	Inhibition of mitochondrial respiration by low concentrations of NO at critical O2 concentrations also leads to prevention of the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) due to the redistribution of O2 towards non-respiratory O2-dependent targets.	Oxygen	221-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
28162290-7	2015	Inhibition of mitochondrial respiration by low concentrations of NO at critical O2 concentrations also leads to prevention of the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) due to the redistribution of O2 towards non-respiratory O2-dependent targets.	Oxygen	221-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-178
28162290-7	2015	Inhibition of mitochondrial respiration by low concentrations of NO at critical O2 concentrations also leads to prevention of the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) due to the redistribution of O2 towards non-respiratory O2-dependent targets.	Oxygen	221-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
26026624-14	2015	Oxygen saturation (p = 0.019), poor sleep quality (p &lt;0.01), and Quinghai score of &gt;=6 (p = 0.026) were independently associated with RLS diagnosis.	Oxygen	0-6	RLS1	Homo sapiens	140-143
26026624-15	2015	CONCLUSIONS: Our results did not show a direct association between RLS and CMS; however, RLS was associated with reduced oxygen saturation.	Oxygen	121-127	RLS1	Homo sapiens	89-92
25827082-8	2015	IER3 expression was induced by Activin A, which plays a crucial role in adipocyte differentiation as well as by a decrease in oxygen tension through HIF1-induced transcriptional activation.	Oxygen	126-132	immediate early response 3	Homo sapiens	0-4
25827082-8	2015	IER3 expression was induced by Activin A, which plays a crucial role in adipocyte differentiation as well as by a decrease in oxygen tension through HIF1-induced transcriptional activation.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-153
26205723-1	2015	According to the data of reverse-transcription-PCR, long-term culturing of multipotent mesenchymal stromal cells from human adipose tissue at 1% O2 (vs. standard 20% O2) led to a decrease in HIF-1alpha gene expression, while no changes in this parameter were revealed at 5% O2.	Oxygen	145-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
26085096-4	2015	In PC12 cells, a small fraction of nitrated Hsp90 was located on the mitochondrial outer membrane and down-regulated mitochondrial membrane potential, oxygen consumption, and ATP production.	Oxygen	151-157	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	44-49
26223692-1	2015	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
26223692-1	2015	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
26214510-10	2015	In comparison of the invasive trophoblasts under normoxia and oxygenated conditions, the ratio of PlGF gene expression and protein expression under oxygenation (2% O2+8% O2 / 2% O2+2% O2) in the active-smokers were both significantly higher than in the non-smokers.	Oxygen	164-166	placental growth factor	Homo sapiens	98-102
26095764-4	2015	The decomposition of the MPAN-OH adduct yields HMML + NO3 (~75%) and hydroxyacetone + CO + NO3 (~25%), out-competing its reaction with atmospheric oxygen.	Oxygen	147-153	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
26153230-4	2015	Moreover, low O2 availability (hypoxia) impedes progenitor-dependent myogenesis in vitro through multiple mechanisms, including activation of hypoxia inducible factor 1alpha (HIF1alpha).	Oxygen	14-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-173
26153230-4	2015	Moreover, low O2 availability (hypoxia) impedes progenitor-dependent myogenesis in vitro through multiple mechanisms, including activation of hypoxia inducible factor 1alpha (HIF1alpha).	Oxygen	14-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-184
26051600-4	2015	Selectivity for Pb(II) is markedly improved as compared to the oxygen analogue 1 which was also competitive for Ca(II) ion.	Oxygen	63-69	submaxillary gland androgen regulated protein 3B	Homo sapiens	16-22
26050709-0	2015	Density Functional Theory Insights into the Role of the Methionine-Tyrosine-Tryptophan Adduct Radical in the KatG Catalase Reaction: O2 Release from the Oxyheme Intermediate.	Oxygen	133-135	catalase	Homo sapiens	114-122
26086541-12	2015	Moreover, we have found that the base pair oxygen of the DNA has a greater preference to form hydrogen bonds than the backbone oxygen with Abeta at the two ends.	Oxygen	43-49	amyloid beta precursor protein	Homo sapiens	139-144
26086541-12	2015	Moreover, we have found that the base pair oxygen of the DNA has a greater preference to form hydrogen bonds than the backbone oxygen with Abeta at the two ends.	Oxygen	127-133	amyloid beta precursor protein	Homo sapiens	139-144
25995271-5	2015	In JAR cells, low oxygen tension (1% O2) induced NFAT5 mRNA and increased its nuclear abundance, peaking at 16 h. This increase did not occur in parallel with the earlier HIF1A induction.	Oxygen	37-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-176
26258123-3	2015	Central to the molecular mechanisms underlying O2 homeostasis are the hypoxia-inducible factors-1 and -2 alpha (HIF-1alpha and EPAS1/HIF-2alpha) that function as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
25723768-2	2015	The bio-bar-coded Pt nanoparticles (NPs)/G-quadruplex/hemin exhibited high CAT-like activity following the Michaelis-Menten model for decomposing H2O2 to water and oxygen, whose activity even slightly exceeded that of natural CAT.	Oxygen	164-170	catalase	Homo sapiens	75-78
25723768-2	2015	The bio-bar-coded Pt nanoparticles (NPs)/G-quadruplex/hemin exhibited high CAT-like activity following the Michaelis-Menten model for decomposing H2O2 to water and oxygen, whose activity even slightly exceeded that of natural CAT.	Oxygen	164-170	catalase	Homo sapiens	226-229
25723768-4	2015	Oxygen in situ generated by the CAT mimetics of the bio-bar-code of Pt NPs/G-quadruplex/hemin acted as an efficient electron acceptor of illuminated PbS QDs, promoting charge separation and enhancing cathodic photocurrent.	Oxygen	0-6	catalase	Homo sapiens	32-35
26025927-8	2015	In addition, mitophagy was induced by deletion of p53, with this effect being weakened by Parkin knockdown at a low oxygen tension.	Oxygen	116-122	tumor protein p53	Homo sapiens	50-53
26136527-0	2015	Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.	Oxygen	98-100	elastase, neutrophil expressed	Rattus norvegicus	0-19
26136527-4	2015	Exposure to 60% O2 was associated with increased lung contents of neutrophil elastase and alpha-elastin, a marker of denatured elastin, and a decrease in elastin fiber density.	Oxygen	16-18	elastase, neutrophil expressed	Rattus norvegicus	66-85
26136527-5	2015	This led us to speculate that neutrophil elastase-induced elastin fragments were the chemokines that led to a LM influx into the 60% O2-exposed lung.	Oxygen	133-135	elastase, neutrophil expressed	Rattus norvegicus	30-49
25695948-4	2015	Here, we identified a sulfated derivative of the Escherichia coli polysaccharide K5 [K5-N,OS(H)] as a multitarget molecule highly effective in inhibiting VEGF-driven angiogenic responses in different in vitro, ex vivo, and in vivo assays, including a murine model of oxygen-induced retinopathy.	Oxygen	267-273	vascular endothelial growth factor A	Homo sapiens	154-158
25638347-7	2015	Nitroglycerin and antihypertensive drugs such as beta-blockers, ACE inhibitors or calcium channel blockers may also be used to lower blood pressure and to improve the oxygen demand of heart.	Oxygen	167-173	angiotensin I converting enzyme	Homo sapiens	64-67
25843656-7	2015	Activation of the mTOR-YY1-PGC1alpha pathway by FGF21 in myoblasts regulated energy homeostasis as demonstrated by significant increases in intracellular ATP synthesis, oxygen consumption rate, activity of citrate synthase, glycolysis, mitochondrial DNA copy number, and induction of the expression of key energy metabolic genes.	Oxygen	169-175	mechanistic target of rapamycin kinase	Homo sapiens	18-22
25837584-8	2015	Cyp-D silencing reduced mitochondrial membrane potential and cellular oxygen consumption (from 59 +- 5 to 34 +- 1 micromol oxygen/min/10(6) cells, P &lt; 0.001); the latter without a statistically significant reversal after uncoupling electron transport from ATP synthesis, consistent with down-regulation of electron transport complexes.	Oxygen	70-76	peptidylprolyl isomerase F	Homo sapiens	0-5
25837584-8	2015	Cyp-D silencing reduced mitochondrial membrane potential and cellular oxygen consumption (from 59 +- 5 to 34 +- 1 micromol oxygen/min/10(6) cells, P &lt; 0.001); the latter without a statistically significant reversal after uncoupling electron transport from ATP synthesis, consistent with down-regulation of electron transport complexes.	Oxygen	123-129	peptidylprolyl isomerase F	Homo sapiens	0-5
25934456-6	2015	Notably, this interaction between dimensionality and oxygen status via IL-8 increased angiogenic sprouting in a 3D endothelial invasion assay.	Oxygen	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25031207-0	2015	An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-beta1.	Oxygen	40-46	interleukin 6	Rattus norvegicus	135-139
25031207-0	2015	An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-beta1.	Oxygen	40-46	transforming growth factor, beta 1	Rattus norvegicus	145-154
25843656-7	2015	Activation of the mTOR-YY1-PGC1alpha pathway by FGF21 in myoblasts regulated energy homeostasis as demonstrated by significant increases in intracellular ATP synthesis, oxygen consumption rate, activity of citrate synthase, glycolysis, mitochondrial DNA copy number, and induction of the expression of key energy metabolic genes.	Oxygen	169-175	fibroblast growth factor 21	Homo sapiens	48-53
25604781-0	2015	Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme Oxygenase 1 Expression: PI3K/Akt/Nrf2 Pathway Involved.	Oxygen	11-17	heme oxygenase 1	Mus musculus	108-124
25604781-0	2015	Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme Oxygenase 1 Expression: PI3K/Akt/Nrf2 Pathway Involved.	Oxygen	11-17	thymoma viral proto-oncogene 1	Mus musculus	142-145
25604781-0	2015	Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme Oxygenase 1 Expression: PI3K/Akt/Nrf2 Pathway Involved.	Oxygen	11-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
25604781-7	2015	Hyperbaric oxygen preconditioning increased expression of HO-1, which was suppressed by PI3K inhibitor LY294002, Nrf2 knockout, and Akt inhibitor triciribine.	Oxygen	11-17	heme oxygenase 1	Mus musculus	58-62
25604781-7	2015	Hyperbaric oxygen preconditioning increased expression of HO-1, which was suppressed by PI3K inhibitor LY294002, Nrf2 knockout, and Akt inhibitor triciribine.	Oxygen	11-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-117
25604781-7	2015	Hyperbaric oxygen preconditioning increased expression of HO-1, which was suppressed by PI3K inhibitor LY294002, Nrf2 knockout, and Akt inhibitor triciribine.	Oxygen	11-17	thymoma viral proto-oncogene 1	Mus musculus	132-135
25604781-8	2015	The expression of Nrf2 was enhanced by hyperbaric oxygen preconditioning, but decreased by LY294002 and triciribine.	Oxygen	50-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
25604781-9	2015	The Akt was also activated by hyperbaric oxygen preconditioning but suppressed by LY294002.	Oxygen	41-47	thymoma viral proto-oncogene 1	Mus musculus	4-7
25604781-11	2015	CONCLUSION: These data present a novel signaling mechanism by which hyperbaric oxygen preconditioning protects myocardium ischemia-reperfusion injury via PI3K/Akt/Nrf2-dependent antioxidant defensive system.	Oxygen	79-85	thymoma viral proto-oncogene 1	Mus musculus	159-162
25604781-11	2015	CONCLUSION: These data present a novel signaling mechanism by which hyperbaric oxygen preconditioning protects myocardium ischemia-reperfusion injury via PI3K/Akt/Nrf2-dependent antioxidant defensive system.	Oxygen	79-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
26155978-7	2015	Human mesenchymal stromal cells cultured on casted films of these oxygen-releasing composites required catalase to proliferate, indicating the production of cytotoxic hydrogen peroxide as intermediate.	Oxygen	66-72	catalase	Homo sapiens	103-111
25982178-3	2015	Here, we demonstrate that while there is no detectable difference in the hypoxic level of bone marrow infiltrated by acute myeloid leukemia (AML) and healthy bone marrow, physiological hypoxia of 1% O2 itself leads to cell cycle arrest of AML blasts (both cell lines and primary AML samples) in the G0/G1 phase with upregulation of p27 and consecutive decrease of cells in the S phase.	Oxygen	199-201	dynactin subunit 6	Homo sapiens	332-335
25519716-6	2015	In addition, the ratio of BAX/BCL2 also increased after adding vitamin C under conditions of 2% O2, while the gene expression level of BCL2 increased after adding vitamin C under increasing oxygen concentrations.	Oxygen	96-98	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
26170997-8	2015	Immunohistochemical analysis also indicated that hyperbaric oxygen increased positive staining for Ki-67 and CD34, while reducing staining for TUNEL (a marker of apoptosis).	Oxygen	60-66	CD34 molecule	Homo sapiens	109-113
25519716-6	2015	In addition, the ratio of BAX/BCL2 also increased after adding vitamin C under conditions of 2% O2, while the gene expression level of BCL2 increased after adding vitamin C under increasing oxygen concentrations.	Oxygen	96-98	BCL2 apoptosis regulator	Homo sapiens	30-34
25519716-6	2015	In addition, the ratio of BAX/BCL2 also increased after adding vitamin C under conditions of 2% O2, while the gene expression level of BCL2 increased after adding vitamin C under increasing oxygen concentrations.	Oxygen	190-196	BCL2 apoptosis regulator	Homo sapiens	135-139
26170654-10	2015	Among patients with low transcutaneous oxygen saturation during exacerbations, PaO2 (partial oxygen pressure) correlated with concentrations of MPO and NE protein and neutrophils in a negative manner.	Oxygen	39-45	myeloperoxidase	Homo sapiens	144-147
25930012-11	2015	When oxygen is present in the feed gas or ambient, high levels of oxidation with low concentrations of NO3 on the surface were observed.	Oxygen	5-11	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
25934465-13	2015	Although exposure to high-concentration oxygen prolongs the duration of PAI-1 mRNA overexpression in ALI, inhaled NO can reduce this effect and alleviate both fibrin deposition and lung injury.	Oxygen	40-46	serpin family E member 1	Rattus norvegicus	72-77
26170654-10	2015	Among patients with low transcutaneous oxygen saturation during exacerbations, PaO2 (partial oxygen pressure) correlated with concentrations of MPO and NE protein and neutrophils in a negative manner.	Oxygen	93-99	myeloperoxidase	Homo sapiens	144-147
26066988-1	2015	Ratiometric molecular probes RP1 and RP2 consisting of a blue fluorescent coumarin and a red phosphorescent cationic iridium complex connected by a tetra- or octaproline linker, respectively, were designed and synthesized for sensing oxygen levels in living cells.	Oxygen	234-240	RP2 activator of ARL3 GTPase	Homo sapiens	37-40
26075742-12	2015	There were also significant effects due to oxygen tension on gene expression, wherein there was greater collagen type I, collagen type II, SOX9 and less MMP13 expression on tissue culture plastic compared to synoviocyte matrix.	Oxygen	43-49	matrix metallopeptidase 13	Homo sapiens	153-158
26066988-8	2015	Thus, the intracellular oxygen levels of MCF-7 cells could be imaged by ratiometric emission measurements using the complex RP2.	Oxygen	24-30	RP2 activator of ARL3 GTPase	Homo sapiens	124-127
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	26-32	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	121-128
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	217-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	217-223	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	121-128
26066988-4	2015	The ratios (R(I) = (I(p)/I(f))) between the phosphorescence (I(p)) and fluorescence (I(f)) intensities showed excellent oxygen responses; the ratio of R(I) under degassed and aerated conditions ( R(I)(0) was 20.3 and 19.6 for RP1 and RP2.	Oxygen	120-126	RP2 activator of ARL3 GTPase	Homo sapiens	234-237
26066988-7	2015	The complex RP2 with an octaproline linker provided ratios comparable to the ratiometric measurements obtained using a microplate reader: the ratio of the R(I)) value of RP2 under hypoxia (2.5% O2) to that under normoxia (21% O2) was 1.5 and 1.7 for HeLa and MCF-7 cells, respectively.	Oxygen	194-196	RP2 activator of ARL3 GTPase	Homo sapiens	12-15
26066988-7	2015	The complex RP2 with an octaproline linker provided ratios comparable to the ratiometric measurements obtained using a microplate reader: the ratio of the R(I)) value of RP2 under hypoxia (2.5% O2) to that under normoxia (21% O2) was 1.5 and 1.7 for HeLa and MCF-7 cells, respectively.	Oxygen	226-228	RP2 activator of ARL3 GTPase	Homo sapiens	12-15
26089800-2	2015	Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis.	Oxygen	93-99	erythropoietin	Homo sapiens	0-3
26052946-10	2015	Hypoxic exposure (oxygen partial pressure = 5 kPa) in turn caused a significant increase in the level of Hif-1alpha protein even at 1 dpf and in later stages, while neither Hif-2alpha nor Hif-3alpha protein level were affected.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha a	Danio rerio	105-115
25931124-6	2015	In addition, apelin increases the basal activity of brown adipocytes, as evidenced by the increased PGC1alpha and UCP1 expressions, mitochondrial biogenesis, and oxygen consumption.	Oxygen	162-168	apelin	Homo sapiens	13-19
26065064-2	2015	In response to low tissue oxygen levels in anaemia the kidney produces the hormone erythropoietin which stimulates the bone marrow to produce red blood cells.	Oxygen	26-32	erythropoietin	Homo sapiens	83-97
26039450-6	2015	Conversely, knockdown of ACL in myotubes not only reduces mitochondrial complex I, IV, and V activity but also blocks IGF1-induced increases in oxygen consumption.	Oxygen	144-150	insulin like growth factor 1	Homo sapiens	118-122
25746207-5	2015	The HIF-1alpha, AR, VEGF, and IL-8 were upregulated under 3% O2.	Oxygen	61-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
25746207-5	2015	The HIF-1alpha, AR, VEGF, and IL-8 were upregulated under 3% O2.	Oxygen	61-63	vascular endothelial growth factor A	Homo sapiens	20-24
25746207-5	2015	The HIF-1alpha, AR, VEGF, and IL-8 were upregulated under 3% O2.	Oxygen	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
28834658-9	2015	In stepwise regression analyses in CHF, only insulin sensitivity emerged as a predictor of strength per unit area of muscle [standardized coefficient (SC) = 0.45, P = 0.006; diuretic dose, SC = -0.31, P = 0.051; R2  = 0.37, P = 0.001], while age, left ventricular ejection fraction, maximal oxygen consumption, fasting glucose and insulin and blood flow were excluded.	Oxygen	291-297	insulin	Homo sapiens	45-52
25818442-2	2015	One approach to overcome this challenge is to target the cellular hypoxia inducible factor (HIF-1alpha) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of numerous pro-angiogenic genes including vascular endothelial growth factor (VEGF).	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
25818442-2	2015	One approach to overcome this challenge is to target the cellular hypoxia inducible factor (HIF-1alpha) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of numerous pro-angiogenic genes including vascular endothelial growth factor (VEGF).	Oxygen	135-141	vascular endothelial growth factor A	Homo sapiens	239-273
25818442-2	2015	One approach to overcome this challenge is to target the cellular hypoxia inducible factor (HIF-1alpha) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of numerous pro-angiogenic genes including vascular endothelial growth factor (VEGF).	Oxygen	135-141	vascular endothelial growth factor A	Homo sapiens	275-279
25784177-6	2015	The rates of oxygen consumption were decreased only in the carcinogen-treated UCP2 knockout mice, whereas glycolysis was increased only in the carcinogen-treated wild-type mice.	Oxygen	13-19	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	78-82
25857228-2	2015	We previously reported the angiogenic effects of the CGRP family peptide adrenomedullin in oxygen-induced retinopathy; however, the effects of CGRP on ocular angiogenesis remain unknown.	Oxygen	91-97	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	53-57
25936780-3	2015	Oxygen negatively regulates NDRG3 expression at the protein level via the PHD2/VHL system, whereas lactate, produced in excess under prolonged hypoxia, blocks its proteasomal degradation by binding to NDRG3.	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	74-78
26165528-7	2015	RESULTS: While none of the emergency delivery devices performed as well as the head hood, limb tissue oxygenation was greatest when O2 was delivered via the NRB at 15 L min-1.	Oxygen	132-134	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
25858494-1	2015	We tested the hypothesis that inorganic nitrate (NO3 (-)) supplementation would improve muscle oxygenation, pulmonary oxygen uptake (Vo2) kinetics, and exercise tolerance (Tlim) to a greater extent when cycling at high compared with low pedal rates.	Oxygen	95-101	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
25651816-2	2015	During this process, protein disulfide isomerase (PDI) chaperones oxidatively fold their client proteins before endoplasmic reticulum oxireductin 1 (ERO1) oxidase transfers electrons from the reduced PDI to the terminal acceptor, which is usually molecular oxygen and is subsequently reduced to H2O2.	Oxygen	257-263	ER oxidoreductin	Saccharomyces cerevisiae S288C	112-147
25651816-2	2015	During this process, protein disulfide isomerase (PDI) chaperones oxidatively fold their client proteins before endoplasmic reticulum oxireductin 1 (ERO1) oxidase transfers electrons from the reduced PDI to the terminal acceptor, which is usually molecular oxygen and is subsequently reduced to H2O2.	Oxygen	257-263	ER oxidoreductin	Saccharomyces cerevisiae S288C	149-153
25671767-4	2015	We have recently identified the SAM-domain containing protein Anks3 as a potential ANKS6/NPHP16-interacting protein, and report now that Anks3 interacts with several NPHPs as well as with Bicc1 and the oxygen-sensitive asparaginyl hydroxylase HIF1AN.	Oxygen	202-208	ankyrin repeat and sterile alpha motif domain containing 3	Danio rerio	137-142
25873687-1	2015	Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments.	Oxygen	131-137	protoporphyrinogen oxidase	Homo sapiens	0-18
25873687-1	2015	Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments.	Oxygen	131-137	protoporphyrinogen oxidase	Homo sapiens	20-23
25809665-5	2015	In the presence of O2, the alpha subunits are hydroxylated by specific prolyl-4-hydroxylase domain proteins (PHD1, PHD2, and PHD3) and an asparaginyl hydroxylase (factor inhibiting HIF-1, FIH-1).	Oxygen	19-21	egl-9 family hypoxia inducible factor 1	Homo sapiens	115-119
25902947-2	2015	H2O2-driven oxygen (O2) bubble-propelled microrockets were synthesized using CNT and Fe3O4 nanoparticles in the inner surface and covalently conjugating transferrin on the outer surface.	Oxygen	12-18	transferrin	Homo sapiens	153-164
25292361-6	2015	(1)O2 activates a signalling pathway that depends on the two EXECUTER (EX) proteins EX1 and EX2 and triggers a programmed cell death response.	Oxygen	0-5	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	84-87
25292361-7	2015	In seedlings treated with TeA at half-inhibition concentration (1)O2-mediated and EX-dependent signalling is activated as indicated by the rapid and transient up-regulation of (1)O2-responsive genes in wild type, and its suppression in ex1/ex2 mutants.	Oxygen	63-68	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	236-239
26195892-10	2015	Interestingly, the p16(INK4A) expression altered proportionately to the O2 concentration.	Oxygen	72-74	cyclin dependent kinase inhibitor 2A	Homo sapiens	19-22
26195892-10	2015	Interestingly, the p16(INK4A) expression altered proportionately to the O2 concentration.	Oxygen	72-74	cyclin dependent kinase inhibitor 2A	Homo sapiens	23-28
26236158-4	2015	This increases the capacity of the blood to carry oxygen, reduces the hypoxic stimulus and provides a negative feedback of stopping EPO production.	Oxygen	50-56	erythropoietin	Homo sapiens	132-135
25902947-2	2015	H2O2-driven oxygen (O2) bubble-propelled microrockets were synthesized using CNT and Fe3O4 nanoparticles in the inner surface and covalently conjugating transferrin on the outer surface.	Oxygen	2-4	transferrin	Homo sapiens	153-164
25996919-11	2015	Lactate increased NRF-2 nuclear expression and SOD activity probably as counter-regulatory responses to increased O2 -/H2O2.	Oxygen	114-116	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-23
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Oxygen	53-59	bromodomain containing 4	Homo sapiens	83-87
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Oxygen	53-59	bromodomain containing 4	Homo sapiens	126-130
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	247-256
25429101-8	2015	PFCE-O2-treated HbSS mice also had significantly lower pulmonary leukocyte counts, lower interleukin 1beta and interferon gamma levels, and higher interleukin 10 levels than PFCE-air-treated HbSS mice.	Oxygen	5-7	interleukin 1 beta	Mus musculus	89-106
25429101-8	2015	PFCE-O2-treated HbSS mice also had significantly lower pulmonary leukocyte counts, lower interleukin 1beta and interferon gamma levels, and higher interleukin 10 levels than PFCE-air-treated HbSS mice.	Oxygen	5-7	interleukin 10	Mus musculus	147-161
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-162
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-168
26377014-8	2015	As the aniline ring was substituted by a strong electron-withdrawing group (e.g., NO(2), COCH(3), or CF(3)) at the para position, a characteristic phenolate anion was obtained, which was derived from the Smiles rearrangement reaction initiated by the oxygen anion through a four-membered ring transition state.	Oxygen	251-257	cochlin	Homo sapiens	89-93
25918383-1	2015	Hypoxia-inducible factor stimulates the expression of apelin, a potent vasodilator, in response to reduced blood arterial oxygen saturation.	Oxygen	122-128	apelin	Homo sapiens	54-60
25972164-6	2015	In addition, in neurons silenced with siRNA of NCX1 and subjected to oxygen and glucose deprivation (OGD) (3 h) plus reoxygenation (RX) (24 h), the neuroprotection of Class I HDAC inhibitor MS-275 was counteracted, whereas in neurons overexpressing NCX1 and subjected to ischemic preconditioning (PC+OGD/RX), the neurotoxic effect of p300 inhibitor C646 was prevented.	Oxygen	69-75	solute carrier family 8 member A1	Rattus norvegicus	47-51
25895657-3	2015	The photoluminescence measurements showed a substantial enhancement in the ratio of defect emission to band-edge emission for TNF (ratio   7) compared to NW structures (ratio &lt;= 0.4), attributed to the presence of more oxygen defects in TNF sample.	Oxygen	222-228	tumor necrosis factor	Homo sapiens	126-129
25895657-3	2015	The photoluminescence measurements showed a substantial enhancement in the ratio of defect emission to band-edge emission for TNF (ratio   7) compared to NW structures (ratio &lt;= 0.4), attributed to the presence of more oxygen defects in TNF sample.	Oxygen	222-228	tumor necrosis factor	Homo sapiens	240-243
25857330-0	2015	Increased Turnover at Limiting O2 Concentrations by the Thr(387)   Ala Variant of HIF-Prolyl Hydroxylase PHD2.	Oxygen	31-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	105-109
25857330-1	2015	PHD2 is a 2-oxoglutarate, non-heme Fe(2+)-dependent oxygenase that senses O2 levels in human cells by hydroxylating two prolyl residues in the oxygen-dependent degradation domain (ODD) of HIF1alpha.	Oxygen	74-76	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
25857330-1	2015	PHD2 is a 2-oxoglutarate, non-heme Fe(2+)-dependent oxygenase that senses O2 levels in human cells by hydroxylating two prolyl residues in the oxygen-dependent degradation domain (ODD) of HIF1alpha.	Oxygen	74-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	188-197
25857330-1	2015	PHD2 is a 2-oxoglutarate, non-heme Fe(2+)-dependent oxygenase that senses O2 levels in human cells by hydroxylating two prolyl residues in the oxygen-dependent degradation domain (ODD) of HIF1alpha.	Oxygen	52-58	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
25857330-1	2015	PHD2 is a 2-oxoglutarate, non-heme Fe(2+)-dependent oxygenase that senses O2 levels in human cells by hydroxylating two prolyl residues in the oxygen-dependent degradation domain (ODD) of HIF1alpha.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	188-197
25857330-4	2015	Here we tested the impact of the side chain of Thr(387) on the reactivity of PHD2 toward O2 through a combination of point mutagenesis, steady state kinetic experiments and {FeNO}(7) EPR spectroscopy.	Oxygen	89-91	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
25857330-7	2015	Here we show that the side chain of residue Thr(387) plays a significant role in determining the rate of turnover by PHD2 at low O2 concentrations.	Oxygen	129-131	egl-9 family hypoxia inducible factor 1	Homo sapiens	117-121
25834102-6	2015	PIM1 was markedly up-regulated in multiple HCC cell lines in hypoxic condition (1% O2) versus normoxia (20% O2).	Oxygen	83-85	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
25834102-6	2015	PIM1 was markedly up-regulated in multiple HCC cell lines in hypoxic condition (1% O2) versus normoxia (20% O2).	Oxygen	108-110	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
24985791-7	2015	IL-6 and MIP-1beta levels in NPA were directly correlated to oxygen therapy.	Oxygen	61-67	interleukin 6	Homo sapiens	0-4
25940685-1	2015	There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-204
25820907-7	2015	Lactate dehydrogenase release and crystal violet staining revealed that IL-27 or IL-6 significantly attenuated severe hypoxia (SH, 2 % O2)-induced cell damage in H9c2 cardiomyoblasts and primary rat neonatal cardiomyocytes.	Oxygen	135-137	interleukin 6	Mus musculus	81-85
25637186-1	2015	HIF-1alpha is degraded by oxygen-dependent mechanisms but stabilized in hypoxia to form transcriptional complex HIF-1, which transactivates genes promoting cancer hallmarks.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
25637186-1	2015	HIF-1alpha is degraded by oxygen-dependent mechanisms but stabilized in hypoxia to form transcriptional complex HIF-1, which transactivates genes promoting cancer hallmarks.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
25576887-8	2015	Exposure to 18% oxygen did not phosphorylate extracellular signal regulated kinases (ERK1/2) or AMP activated protein kinase (AMPK), but it phosphorylated protein kinase B (Akt).	Oxygen	16-22	AKT serine/threonine kinase 1	Rattus norvegicus	173-176
25576887-12	2015	We conclude that PI3K/Akt signalling pathway and LDH play a crucial role in increase of cardiac SUR2A induced by in vivo exposure to 18% oxygen.	Oxygen	137-143	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
25703138-3	2015	A link between RAGE and oxygen levels is evident from studies showing RAGE-mediated injury following hyperoxia.	Oxygen	24-30	advanced glycosylation end product-specific receptor	Mus musculus	15-19
25303683-1	2015	We hypothesized that O2 tension influences the redox state and the immunomodulatory responses of inflammatory cells to dimethyl fumarate (DMF), an activator of the nuclear factor Nrf2 that controls antioxidant genes expression.	Oxygen	21-23	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
25648080-3	2015	Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage.	Oxygen	11-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
25510668-3	2015	A common variant of HIF-1alpha (1772C&gt;T) (rs 11549465) polymorphism, corresponding to an amino acid change from proline to serine at 582 position within the oxygen-dependent degradation domain, results in increased stability of the protein and altered transactivation of its target genes.	Oxygen	160-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-30
24402441-8	2015	Mean VO(2max) was 5.18 +- 0.66 l O2 min-1 corresponding to 57.0 +- 4.1 mL O2 min-1 kg-1.	Oxygen	33-35	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
25779537-3	2015	The hypoxia-inducible factor 1alpha (HIF-1alpha) is a central regulator of the pathophysiological response of mammalian cells to low oxygen levels.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
25779537-3	2015	The hypoxia-inducible factor 1alpha (HIF-1alpha) is a central regulator of the pathophysiological response of mammalian cells to low oxygen levels.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
25336286-8	2015	Oxygen plasma-treated rods resulted in loose tissue arrangement, collagen, and collagen/TGF-beta-coated rods yielded thick, collagen-rich, densely packed tissue capsules, though with a random distribution of myofibroblasts.	Oxygen	0-6	transforming growth factor, beta 1	Rattus norvegicus	88-96
25569379-8	2015	These results suggest that the complex structural remodeling of the matrix might reduce oxygen availability in the valve cusp contributing to the stabilization of HIF-1alpha that in turn induces a metabolic adaptation through the upregulation of VEGF and the formation of new blood vessels not only to overcome the hypoxic state but also to sustain the calcification process.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	163-173
25995618-0	2015	The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.	Oxygen	61-67	cellular communication network factor 1	Mus musculus	17-21
25569379-8	2015	These results suggest that the complex structural remodeling of the matrix might reduce oxygen availability in the valve cusp contributing to the stabilization of HIF-1alpha that in turn induces a metabolic adaptation through the upregulation of VEGF and the formation of new blood vessels not only to overcome the hypoxic state but also to sustain the calcification process.	Oxygen	88-94	vascular endothelial growth factor A	Homo sapiens	246-250
25995618-0	2015	The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.	Oxygen	61-67	thymoma viral proto-oncogene 1	Mus musculus	101-104
25798900-4	2015	A paramagnetic S = 3/2 impurity that forms during the synthesis of [Co(II)(dmgH)2P(nBu)3] when exposed to adventitious oxygen has also been characterized.	Oxygen	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
25892103-1	2015	Low oxygen environments are a hallmark of solid tumors, and transcription of many hypoxia-responsive genes needed for survival under these conditions is regulated by the transcription factor HIF-1 (hypoxia-inducible factor 1).	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-196
25892103-1	2015	Low oxygen environments are a hallmark of solid tumors, and transcription of many hypoxia-responsive genes needed for survival under these conditions is regulated by the transcription factor HIF-1 (hypoxia-inducible factor 1).	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-224
25919031-9	2014	These changes were at least partly ensured by the increased concentration of MCP-1 and IL-8 at 5% O2.	Oxygen	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25900271-4	2015	In particular, the discovery of the role of oxygen-dependent hydroxylase enzymes in modulating the activity of HIF-1alpha has sparked interest in potentially promising therapeutic strategies in multiple clinical fields and most recently bone healing.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
25772087-1	2015	Highly oxidizing nitrate radicals (NO3 ) are easily accessed from readily available nitrate salts by visible light photoredox catalysis using a purely organic dye as the catalyst and oxygen as the terminal oxidant.	Oxygen	183-189	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
25659740-3	2015	The Cu(II) and Co(II) complexes interacted with CT-DNA via intercalative mode with the respective Kb value of 3.2x10(4) M(-1) and 2.9x10(4) M(-1) and acted as proficient photocleavers of SC pUC19 DNA in UV-A light, forming (1)O2 as the reactive oxygen species with the quantum yield of 0.38 and 0.36, respectively.	Oxygen	226-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
26131111-1	2015	Neuroglobin (Ngb) is well known as a physiological role in oxygen homeostasis of neurons and perhaps a protective role against hypoxia and oxidative stress.	Oxygen	59-65	neuroglobin	Rattus norvegicus	0-11
26131111-1	2015	Neuroglobin (Ngb) is well known as a physiological role in oxygen homeostasis of neurons and perhaps a protective role against hypoxia and oxidative stress.	Oxygen	59-65	neuroglobin	Rattus norvegicus	13-16
25608933-6	2015	In this context, four types of NHC-complexes, i.e., carbon-functionalized NHCs, nitrogen-functionalized NHCs, oxygen-functionalized NHCs and nitrogen/oxygen-functionalized unsymmetric NHCs, are described.	Oxygen	110-116	high mobility group nucleosomal binding domain 4	Homo sapiens	31-34
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	82-87
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	82-85
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	148-153
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Oxygen	200-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
25867881-0	2015	Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score): a prospective cohort study with external validation.	Oxygen	136-142	zinc finger protein 746	Homo sapiens	159-164
25742117-7	2015	In conclusion, our study shows an unexpected role of lipids as orchestrators of chondrogenesis in response to oxygen tension which is, at least in part, mediated through FGF-1.	Oxygen	110-116	fibroblast growth factor 1	Homo sapiens	170-175
25608933-6	2015	In this context, four types of NHC-complexes, i.e., carbon-functionalized NHCs, nitrogen-functionalized NHCs, oxygen-functionalized NHCs and nitrogen/oxygen-functionalized unsymmetric NHCs, are described.	Oxygen	150-156	high mobility group nucleosomal binding domain 4	Homo sapiens	31-34
25793416-1	2015	Cytochrome P450 enzymes are renowned for their ability to insert oxygen into an enormous variety of compounds with a high degree of chemo- and regio-selectivity under mild conditions.	Oxygen	65-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
25700580-3	2015	Angiotensin II contributes to the production and release of oxygen reactive species that react with nitric oxide, inactivating its effects.	Oxygen	60-66	angiotensinogen	Homo sapiens	0-14
25608846-3	2015	The catalytic performance of iNOS is proposed to rely mainly on the haem midpoint potential and the ability of the substrate L-Arg to provide a hydrogen bond for oxygen activation (O-O scission).	Oxygen	162-168	nitric oxide synthase 2	Homo sapiens	29-33
25789734-2	2015	Prior studies of the ROX Coupler show that it increases cardiac output, oxygen delivery, and decreases systemic vascular resistance, thereby lowering blood pressure.	Oxygen	72-78	MAX network transcriptional repressor	Homo sapiens	21-24
26173295-0	2015	Upregulation of Bcl-2 enhances secretion of growth factors by   adipose-derived stem cells deprived of oxygen and glucose.	Oxygen	103-109	BCL2 apoptosis regulator	Homo sapiens	16-21
26173295-9	2015	In addition, Bcl-2 overexpression enhanced the secretion of VEGF, bFGF, and HGF by 14.47%, 16.9%, and 91%, respectively, compared to ADSCs alone that were deprived of oxygen and glucose.	Oxygen	167-173	BCL2 apoptosis regulator	Homo sapiens	13-18
26173295-10	2015	These data suggest that Bcl-2 overexpression enhances secretion of angiogenic growth factors by ADSCs deprived of oxygen and glucose.	Oxygen	114-120	BCL2 apoptosis regulator	Homo sapiens	24-29
25676362-3	2015	These results suggested that Cu(II)-catalyzed phenol autoxidation by activating O2 and phenol in terms of a phenoxy radical (ArO)-Cu(II)-superoxide ternary complex, whereas selectivity between oxygenation and coupling depends mainly on the electronic structure of ArO.	Oxygen	80-82	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	125-128
25676362-3	2015	These results suggested that Cu(II)-catalyzed phenol autoxidation by activating O2 and phenol in terms of a phenoxy radical (ArO)-Cu(II)-superoxide ternary complex, whereas selectivity between oxygenation and coupling depends mainly on the electronic structure of ArO.	Oxygen	80-82	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	264-267
25585871-5	2015	Under optimized 2.0 V of applied potential, 38 C of temperature, and 500 mL min(-1) of oxygen flow, over 90% of phenol, 60% of TOC and 20% of salinity were removed during 300 min of electrolysis time.	Oxygen	87-93	CD59 molecule (CD59 blood group)	Homo sapiens	76-82
26257575-2	2015	Here we explore approaches to rapid "assembly" of novel photoprecursors with nitrogen/oxygen-rich tethers capable of producing potential pharmacophores and also compatible with subsequent 1,3-dipolar cycloadditions to furnish pentacyclic heterocycles with new structural cores, minimal number of rotatable bonds, and a high content of sp3 hybridized carbons.	Oxygen	86-92	Sp3 transcription factor	Homo sapiens	335-338
25744979-14	2015	OPA1 mutant cells also displayed reduced oxygen consumption and underwent glycolysis to produce ATP.	Oxygen	41-47	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	0-4
25550463-1	2015	Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric alpha/beta transcription factors that regulate cellular responses to low oxygen.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-40
25598140-5	2015	Here, we find that in an in vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is pathological activation of the calcium/calmodulin-dependent protein kinase kinase beta (CaMKKbeta)-AMPKalpha1 signalling pathway.	Oxygen	76-82	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	223-233
25627142-0	2015	Immobilized cytochrome c bound to cardiolipin exhibits peculiar oxidation state-dependent axial heme ligation and catalytically reduces dioxygen.	Oxygen	136-144	cytochrome c, somatic	Homo sapiens	12-24
25230001-6	2015	RESULTS: Peak oxygen consumption (VO2peak) and heart rate in UBT and TMT were 34.1 +- 4.1 vs 58.3 +- 2.6 mL   min-1   kg-1 and 185 +- 8 vs 197 +- 8 beats/min, respectively, and both variables were of significantly lower magnitude during UBT (P &lt; .001).	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	110-130
25491171-1	2015	Trans-sodium crocetinate (TSC) is a novel synthetic carotenoid compound that improves diffusion of small molecules, including oxygen, in solutions.	Oxygen	126-132	solute carrier family 12, member 3	Mus musculus	26-29
25598140-8	2015	We show that in an in vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is a pathological activation of the CaMKKbeta-AMPKalpha1 signalling pathway.	Oxygen	70-76	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	161-171
25684657-6	2015	RESULTS: A hypoxic reaction with stabilization of HIF1A protein as well as up-regulation of HIF1A and VEGFA gene expressions, but without any hint for apoptosis, was present at 0.1% and 1% oxygen.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
24703425-9	2015	In luciferase assays and EMSA, the inducing effect of low oxygen could be assigned to HIF-1alpha, which binds to hypoxia responsive elements (HRE) in the OSTalpha and OSTbeta gene promoters.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
24703425-9	2015	In luciferase assays and EMSA, the inducing effect of low oxygen could be assigned to HIF-1alpha, which binds to hypoxia responsive elements (HRE) in the OSTalpha and OSTbeta gene promoters.	Oxygen	58-64	solute carrier family 51 subunit beta	Homo sapiens	167-174
25831278-4	2015	The feasibility of the method was tested on oxygen saturated hemoglobin and deoxygenated hemoglobin in vitro in a blood circulating rig.	Oxygen	44-50	DIRAS family, GTP-binding RAS-like 1	Mus musculus	132-135
25699588-4	2015	Down-regulation of PSBR expression diminished the efficiency of oxygen evolution and the extent of nonphotochemical quenching and had an impact on the stability of the oxygen-evolving complex as well as on PSII-LHCII-LHCSR3 supercomplex formation.	Oxygen	64-70	uncharacterized protein	Chlamydomonas reinhardtii	19-23
25699588-4	2015	Down-regulation of PSBR expression diminished the efficiency of oxygen evolution and the extent of nonphotochemical quenching and had an impact on the stability of the oxygen-evolving complex as well as on PSII-LHCII-LHCSR3 supercomplex formation.	Oxygen	168-174	uncharacterized protein	Chlamydomonas reinhardtii	19-23
25154023-3	2015	Catalase gene encodes an antioxidant enzyme, detoxifying hydrogen peroxide to H2O and O2.	Oxygen	86-88	catalase	Homo sapiens	0-8
25742254-5	2015	Among the four concentrations of AVP, 5 x 10 U/mL had the best effect: it significantly improved hemodynamics and increased cardiac function, oxygen delivery, as well as hepatic blood flow and hepatic function in the shock rats.	Oxygen	142-148	arginine vasopressin	Rattus norvegicus	33-36
25684657-6	2015	RESULTS: A hypoxic reaction with stabilization of HIF1A protein as well as up-regulation of HIF1A and VEGFA gene expressions, but without any hint for apoptosis, was present at 0.1% and 1% oxygen.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-97
25684657-6	2015	RESULTS: A hypoxic reaction with stabilization of HIF1A protein as well as up-regulation of HIF1A and VEGFA gene expressions, but without any hint for apoptosis, was present at 0.1% and 1% oxygen.	Oxygen	189-195	vascular endothelial growth factor A	Homo sapiens	102-107
25648699-7	2015	Neutralizing antibody against VEGF-C ameliorated pathological angiogenesis in oxygen-induced retinopathy lesions.	Oxygen	78-84	vascular endothelial growth factor C	Mus musculus	30-36
26069529-1	2015	The purpose of this in vitro study was to develop a useful biomarker (e.g., cellular respiration, or mitochondrial O2 consumption) for measuring activities of mTOR inhibitors.	Oxygen	115-117	mechanistic target of rapamycin kinase	Homo sapiens	159-163
25711811-2	2015	Recombinant AIR12 from Arabidopsis accepted electrons from ascorbate or superoxide, and donated electrons to either monodehydroascorbate or oxygen.	Oxygen	140-146	auxin-induced in root cultures-like protein	Arabidopsis thaliana	12-17
25807077-5	2015	Three tumor cell lines (breast cancer MCF-7, colon cancer HCT116 and glioblastoma U87) showed a quick relocation of mTOR to mitochondria after irradiation with a single dose 5 Gy, which was companied with decreased lactate production, increased mitochondrial ATP generation and oxygen consumption.	Oxygen	278-284	mechanistic target of rapamycin kinase	Homo sapiens	116-120
25803180-5	2015	The transcription factor HIF-1 functions as a key regulator of oxygen homeostasis.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-30
25803180-8	2015	Mechanistic studies revealed that kalkitoxin inhibits HIF-1 activation by suppressing mitochondrial oxygen consumption at electron transport chain (ETC) complex I (NADH-ubiquinone oxidoreductase).	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-59
25785990-0	2015	Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular endothelial growth factor receptor Flk-1.	Oxygen	45-51	vascular endothelial growth factor A	Homo sapiens	110-144
25683572-1	2015	When oxygen is limiting in soils and sediments, microorganisms utilize nitrate (NO3-) in respiration--through the process of denitrification--leading to the production of dinitrogen (N2) gas and trace amounts of nitrous (N2O) and nitric (NO) oxides.	Oxygen	5-11	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
25786132-7	2015	In addition, LPS exposed eNOS-/- mice had increased oxygen saturation and improved lung mechanics.	Oxygen	52-58	toll-like receptor 4	Mus musculus	13-16
25303714-5	2015	There is also genomic evidence of oxygen-tolerant cytochrome c oxidases and oxidative stress-related genes, indicating that others may be exposed to higher oxygen conditions.	Oxygen	34-40	cytochrome c, somatic	Homo sapiens	50-62
25303714-5	2015	There is also genomic evidence of oxygen-tolerant cytochrome c oxidases and oxidative stress-related genes, indicating that others may be exposed to higher oxygen conditions.	Oxygen	156-162	cytochrome c, somatic	Homo sapiens	50-62
25576221-1	2015	Catalase is an important endogenous antioxidant enzyme that detoxifies hydrogen peroxide to oxygen and water, thus limiting the deleterious effects of reactive oxygen species.	Oxygen	92-98	catalase	Homo sapiens	0-8
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	28-34	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	48-51
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	28-34	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	178-181
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	108-114	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	48-51
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	132-139	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	48-51
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	132-139	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	178-181
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	255-262	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	48-51
25733891-4	2015	In particular, the carboxyl oxygen of the alpha-CNP acts as the potential equivalent of the alpha-phosphate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dNTPs.	Oxygen	255-262	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	178-181
25589622-4	2015	Here, we show that the oxygen-sensitive alpha subunit of hypoxia-inducible factor 1 (HIF-1alpha) plays a central role in cancer immune adaptation under conditions of normal oxygen tension.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
25589622-4	2015	Here, we show that the oxygen-sensitive alpha subunit of hypoxia-inducible factor 1 (HIF-1alpha) plays a central role in cancer immune adaptation under conditions of normal oxygen tension.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
25762504-5	2015	A novel approach utilizing electron imaging of ion-polished samples shows that meiofauna pervasively reworked sediment under oxygen-depleted conditions that excluded macrofauna, fragmenting organic laminae and emplacing 15- to 70-mum-diameter faecal pellets without macroscopically influencing the fabric.	Oxygen	125-131	latexin	Homo sapiens	230-233
25550320-3	2015	Due to oxygen deficiency, mammalian cells activate the transcriptional factor hypoxia-inducible factor (HIF); its degradation is regulated by prolyl hydroxylase 3 (PHD3) in interaction with the scaffold protein MAPK organizer 1 (Morg1).	Oxygen	7-13	WD repeat domain 83	Homo sapiens	211-227
25550320-3	2015	Due to oxygen deficiency, mammalian cells activate the transcriptional factor hypoxia-inducible factor (HIF); its degradation is regulated by prolyl hydroxylase 3 (PHD3) in interaction with the scaffold protein MAPK organizer 1 (Morg1).	Oxygen	7-13	WD repeat domain 83	Homo sapiens	229-234
25889814-13	2015	In the extreme hypoxic conditions (0.2% oxygen), the overexpression of CCAAT enhancer-binding proteins (C/EBPs), especially C/EBPdelta, and HIF-1A upregulated the promoter activities of adipocyte-specific genes such as leptin, CFD, HIG2, LPL, PGAR.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-146
25889814-13	2015	In the extreme hypoxic conditions (0.2% oxygen), the overexpression of CCAAT enhancer-binding proteins (C/EBPs), especially C/EBPdelta, and HIF-1A upregulated the promoter activities of adipocyte-specific genes such as leptin, CFD, HIG2, LPL, PGAR.	Oxygen	40-46	hypoxia inducible lipid droplet associated	Homo sapiens	232-236
25792848-7	2015	However, hs-cTnT was significantly correlated with age (P&lt;0.01), blood concentrations of brain natriuretic peptide (P&lt;0.01), reactive oxygen metabolites (markers of oxidative stress, P&lt;0.001), and the cardio-ankle vascular index (marker of arterial function, P&lt;0.01).	Oxygen	140-146	troponin T2, cardiac type	Homo sapiens	12-16
25695878-8	2015	The computed structure of PuO3(NO3)2(-) is essentially a plutonyl(VI) core, Pu(VI)O2(2+), coordinated in the equatorial plane by two nitrate ligands and one radical oxygen atom.	Oxygen	165-171	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
25586178-5	2015	Duox2 released O2 (-) even in correctly matched combinations, including Duox2 + DuoxA2 and Duox2 + N-terminally tagged DuoxA2 regardless of the type or number of tags.	Oxygen	15-17	dual oxidase 2	Homo sapiens	0-5
25746286-5	2015	Compared to beta-Gal control, WT-Hsp22 accumulated in mitochondria by 2.5 fold (P&lt;0.05) and increased oxygen consumption rates by 2-fold (P&lt;0.01).	Oxygen	105-111	heat shock protein family B (small) member 8	Homo sapiens	33-38
25695878-9	2015	The computations indicate that in the ground spin-orbit free state of PuO3(NO3)2(-), the unpaired electron of the oxygen atom is antiferromagnetically coupled to the spin-triplet state of the plutonyl core.	Oxygen	114-120	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
25542506-8	2015	Enhanced oxygen consumption and fatty acid oxidation enzymes, Carnitine palmitoyl transferase 1 and Acyl-coenzyme A oxidase (CPT-1 and ACOX) were also observed.	Oxygen	9-15	carnitine palmitoyltransferase 1A	Homo sapiens	125-130
25552662-0	2015	Mechanisms of C-peptide-mediated rescue of low O2-induced ATP release from erythrocytes of humans with type 2 diabetes.	Oxygen	47-49	insulin	Homo sapiens	14-23
25552662-4	2015	To begin to investigate the mechanisms by which C-peptide influences low O2-induced ATP release, erythrocytes from healthy humans and humans with DM2 were exposed to reduced O2 in a thin-film tonometer, and ATP release under these conditions was compared with release during normoxia.	Oxygen	73-75	insulin	Homo sapiens	48-57
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	26-28	insulin	Homo sapiens	85-94
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	26-28	insulin	Homo sapiens	173-182
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	310-312	insulin	Homo sapiens	173-182
25552662-7	2015	In addition, since both C-peptide and phosphodiesterase 5 inhibitors rescue low O2-induced ATP release from erythrocytes of humans with DM2, their administration to humans with DM2 could aid in the treatment and/or prevention of the vascular disease associated with this condition.	Oxygen	80-82	insulin	Homo sapiens	24-33
25529353-0	2015	How cytochrome c oxidase can pump four protons per oxygen molecule at high electrochemical gradient.	Oxygen	51-57	cytochrome c, somatic	Homo sapiens	4-16
25529353-1	2015	Experiments have shown that the A-family cytochrome c oxidases pump four protons per oxygen molecule, also at a high electrochemical gradient.	Oxygen	85-91	cytochrome c, somatic	Homo sapiens	41-53
25480159-10	2015	Interleukin-10 treatment markedly prolonged the survival of mice during oxygen exposure.	Oxygen	72-78	interleukin 10	Mus musculus	0-14
25703688-3	2015	Hypoxia (3% oxygen) induced cellular proliferation in mouse MSCs and upregulated endogenous angiotensin II and angiotensin-converting enzyme in the cell culture and expression of AT1 receptors.	Oxygen	12-18	angiotensin II receptor, type 1a	Mus musculus	179-182
25703688-8	2015	The data demonstrated that the hypoxia at 3% oxygen level could induce mouse MSC proliferation, probably as a result of the activation of PI3K signalling pathways via AT1 receptors.	Oxygen	45-51	angiotensin II receptor, type 1a	Mus musculus	167-170
25964036-0	2015	Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes.	Oxygen	11-17	insulin	Homo sapiens	36-43
25964036-2	2015	For patients with type 2 diabetes, we recently showed that peripheral insulin sensitivity was increased during hyperbaric oxygen treatment (HBOT).	Oxygen	122-128	insulin	Homo sapiens	70-77
25447313-0	2015	Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells.	Oxygen	0-6	C-terminal binding protein 2	Homo sapiens	65-70
25447313-8	2015	Our results suggest that microenvironmental oxygen levels influence the dimerization and acetylation levels, and thereby the activity, of CtBP2 in proliferating NSCs.	Oxygen	44-50	C-terminal binding protein 2	Homo sapiens	138-143
25480159-13	2015	Furthermore, absence of IL-10 aggravated hyperoxia-induced acute lung injury and reduced the duration of survival of mice during oxygen exposure, which was attenuated by treatment with IL-10.	Oxygen	129-135	interleukin 10	Mus musculus	24-29
25480159-13	2015	Furthermore, absence of IL-10 aggravated hyperoxia-induced acute lung injury and reduced the duration of survival of mice during oxygen exposure, which was attenuated by treatment with IL-10.	Oxygen	129-135	interleukin 10	Mus musculus	185-190
25480159-12	2015	Interleukin-10 treatment suppressed activities of matrix metalloproteinase 2 and matrix metalloproteinase 9 and reduced lung permeability in mice during oxygen exposure.	Oxygen	153-159	interleukin 10	Mus musculus	0-14
25514442-11	2015	That 60% O2-induced impairment of alveologenesis was mediated in part by TGFbeta1 was confirmed by demonstrating an improvement in secondary crest formation when 60% O2-exposed pups received concurrent treatment with the TGFss1 activin receptor-like kinase, SB 431542.	Oxygen	9-11	transforming growth factor, beta 1	Rattus norvegicus	73-81
25552276-2	2015	Many of these changes are directly regulated by the conserved hypoxia-inducible factor-1 (HIF-1) complex; however, even in its absence, many oxygen-sensitive transcripts in Caenorhabditis elegans are appropriately regulated in hypoxia.	Oxygen	141-147	Hypoxia-inducible factor 1	Caenorhabditis elegans	62-88
25552276-2	2015	Many of these changes are directly regulated by the conserved hypoxia-inducible factor-1 (HIF-1) complex; however, even in its absence, many oxygen-sensitive transcripts in Caenorhabditis elegans are appropriately regulated in hypoxia.	Oxygen	141-147	Hypoxia-inducible factor 1	Caenorhabditis elegans	90-95
25514442-11	2015	That 60% O2-induced impairment of alveologenesis was mediated in part by TGFbeta1 was confirmed by demonstrating an improvement in secondary crest formation when 60% O2-exposed pups received concurrent treatment with the TGFss1 activin receptor-like kinase, SB 431542.	Oxygen	166-168	transforming growth factor, beta 1	Rattus norvegicus	73-81
25514442-12	2015	That the increased TGFbeta1 content in lungs of pups exposed to 60% O2 was regulated by peroxynitrite was confirmed by its attenuation by concurrent treatment with a peroxynitrite decomposition catalyst.	Oxygen	68-70	transforming growth factor, beta 1	Rattus norvegicus	19-27
25514442-13	2015	We conclude that peroxynitrite contributes to the impaired alveologenesis observed following the exposure of neonatal rats to 60% O2 both by preventing binding of IGF-I to the IGF-R1, secondary to nitration of the IGF-R1, and by causing an up-regulation of the growth inhibitor, TGFbeta1.	Oxygen	130-132	transforming growth factor, beta 1	Rattus norvegicus	279-287
25369881-6	2015	Erythropoietin administration increases oxygen-carrying capacity of blood improving endurance measures, whereas systemic administration of beta-adrenergic agonists may have positive effect on sprint capacity, and beta-adrenergic antagonists reduce muscle tremor.	Oxygen	40-46	erythropoietin	Homo sapiens	0-14
25780331-10	2015	This study suggests that cilostazol caused an increase in the release of oxygen from hemoglobin as shown in the P50 values.	Oxygen	73-79	nuclear factor kappa B subunit 1	Homo sapiens	112-115
26045804-1	2015	The purpose of this in vitro study was to develop a useful biomarker (e.g., cellular respiration, or mitochondrial O2 consumption) for measuring activities of mTOR inhibitors.	Oxygen	115-117	mechanistic target of rapamycin kinase	Homo sapiens	159-163
25490569-8	2015	In addition, the hydrogen uptake of Pd/AC-ox3 with lower oxygen contents demonstrates that the hydrogen spillover enhancement gradually disappears when the pressure is increased to more than 2 MPa (i.e., a transition from spillover to physisorption).	Oxygen	57-63	acyl-CoA oxidase 3, pristanoyl	Homo sapiens	39-45
25578537-7	2015	Under 20% O2, oocytes and embryos had high expression of PDH indicating higher oxidative phosphorylation.	Oxygen	10-12	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	57-60
26211153-2	2015	METHOD: 46 cases with severe OSAHS were diagnosed by PSG according to AHI and the lowest arterial oxygen saturation (LSaO2).	Oxygen	98-104	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	53-56
25444956-2	2015	Although it is widely accepted that hypoxia induces HIF1alpha expression up-regulation by a reduction in oxygen dependent degradation, HIF1alpha up-regulation under normoxic conditions is noted with increasing frequency in many cancers.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-61
25672499-6	2015	In PAH, acquired mitochondrial abnormalities, including epigenetic silencing of superoxide dismutase (SOD2), disrupt oxygen sensing creating a pseudo-hypoxic environment characterized by normoxic activation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	210-241
25672499-6	2015	In PAH, acquired mitochondrial abnormalities, including epigenetic silencing of superoxide dismutase (SOD2), disrupt oxygen sensing creating a pseudo-hypoxic environment characterized by normoxic activation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	243-253
25412407-11	2015	Effective inhibition of PARP and iNOS, by DPQ and 1400W, was detected by western blotting and immunofluorescence, and was shown to repress O2- and nitrotyrosine levels, following MI.	Oxygen	139-141	nitric oxide synthase 2	Rattus norvegicus	33-37
25624148-7	2015	We observe that this interaction between excess Fe, ferritin, and root system architecture (RSA) is in part mediated by the H2O2/O2 - balance between the root cell proliferation and differentiation zones regulated by the UPB1 transcription factor.	Oxygen	126-128	transcription factor UPBEAT protein	Arabidopsis thaliana	221-225
25528444-2	2015	Herein, we examined the effects of lipopolysaccharide (LPS), the primary ligand for TLR4, on mitochondrial oxygen consumption in skeletal muscle cell culture and mitochondria isolated from rodent skeletal muscle.	Oxygen	107-113	toll-like receptor 4	Mus musculus	84-88
25600213-7	2015	Increased steady-state ROS in mice with forebrain-specific conditional deletion of manganese superoxide dismutase (Sod2(fl/fl)NEX(Cre/Cre)) in mice resulted in profound deficits in mitochondrial oxygen consumption.	Oxygen	195-201	superoxide dismutase 2, mitochondrial	Mus musculus	115-119
25617045-10	2015	The stimulating effect of CrCAH3 and CO2/HCO3 (-) on PSII activity was demonstrated by comparing the flash-induced oxygen evolution pattern of wild-type and CrCAH3-less PSII preparations.	Oxygen	115-121	uncharacterized protein	Chlamydomonas reinhardtii	26-32
25539718-4	2015	METHODS: The neonatal mice were exposed to either hyperoxia or hypoxia in order to detect the pulmonary and cardiac Egfl7 messenger RNA (mRNA) or protein expression regulated by oxygen tension in vivo by reverse transcriptase polymerase chain reaction or immunohistochemistry staining.	Oxygen	178-184	EGF-like domain 7	Mus musculus	116-121
26101492-1	2015	OBJECTIVE: The VEGF in low oxygen conditions are reported to prolong the survival of malignant cell, and thus this gene has a critical role in tumor growth and invasion as well as development of malignant tumor.	Oxygen	27-33	vascular endothelial growth factor A	Homo sapiens	15-19
24870112-9	2015	In multivariate analysis, oxygen desaturation index was the major contributing factor for elevated ALT (beta = 0.435, p = 0.000), average O2 saturation was the major independent predictor of elevated AST (beta = -0.269, p = 0.020).	Oxygen	138-140	solute carrier family 17 member 5	Homo sapiens	200-203
25539718-13	2015	Egfl7 could be a HIF-1alpha responsive gene regulated by oxygen tension.	Oxygen	57-63	EGF-like domain 7	Mus musculus	0-5
25611163-4	2015	On the other hand, in linear trinuclear complex , in addition to the mu2-phenoxido and mu1,1-azido bridges with terminal octahedral Co(III) centres, the central Co(II) is bonded with two mutually trans-oxygen atoms of water molecules.	Oxygen	202-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
25648746-0	2015	Fog-like fluffy structured N-doped carbon with a superior oxygen reduction reaction performance to a commercial Pt/C catalyst.	Oxygen	58-64	zinc finger protein, FOG family member 1	Homo sapiens	0-3
25646428-4	2015	Based on kinetic experiments on the O-O bond splitting transition of the catalytic cycle (A   P(R)), it has been proposed that the electron transfer to the binuclear iron-copper center of O2 reduction initiates the proton pump mechanism.	Oxygen	188-190	LDL receptor related protein 1	Homo sapiens	90-98
25683712-2	2015	HIF-1 regulates many responses to oxygen deprivation, but viable cells within hypoxic perinecrotic solid tumor regions frequently lack HIF-1alpha.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
25713332-9	2015	The attenuated response to CL 316,243 in white adipose tissue in IL-6(-/-) mice was associated with reductions in whole-body oxygen consumption and energy expenditure in the light phase.	Oxygen	125-131	interleukin 6	Mus musculus	65-69
25709425-8	2015	Further, logarithmically transformed hs-cTnT values significantly and negatively correlated with forced vital capacity, FEV1% predicted, diffusion capacity, arterial oxygen tension, and 6-minute walking distance (range r= -0.482 to -0.377, P=0.000 to P=0.002).	Oxygen	166-172	troponin T2, cardiac type	Homo sapiens	40-44
25233291-7	2015	We found that EVCs differentiated under low-oxygen conditions produced copious amounts of collagen IV and fibronectin as well as vascular endothelial growth factor and angiopoietin 2.	Oxygen	44-50	fibronectin 1	Homo sapiens	106-117
25675305-5	2015	Calpain-mediated cleavage of Ret51 was also observed in hippocampal neurons subjected to transient oxygen and glucose deprivation (OGD), a model of global brain ischemia, as well as in the ischemic region in the cerebral cortex of mice exposed to transient middle cerebral artery occlusion.	Oxygen	99-105	ret proto-oncogene	Mus musculus	29-34
25713564-9	2015	Methylophilales (mainly PE2 clade) was positively correlated to dissolved oxygen, whereas Rhodocyclales (mainly R.12up clade) was negatively correlated.	Oxygen	74-80	ETS2 repressor factor	Homo sapiens	24-27
25559492-7	2015	With the formation of the sandwich-type structure of TBA 1, TB, and TBA 2 signal probes, a desirable enhanced ECL signal was measured in the testing buffer of an S2O8(2-)/O2 solution for detecting TB.	Oxygen	171-173	coagulation factor II, thrombin	Homo sapiens	53-55
25531556-1	2015	Correction for "In situ study of the catalytic mechanism for the oxygen reduction reaction on a polypyrrole modified carbon supported cobalt hydroxide cathode in direct borohydride fuel cells" by Haiying Qin et al., Phys.	Oxygen	65-71	forkhead box G1	Homo sapiens	204-207
25559492-7	2015	With the formation of the sandwich-type structure of TBA 1, TB, and TBA 2 signal probes, a desirable enhanced ECL signal was measured in the testing buffer of an S2O8(2-)/O2 solution for detecting TB.	Oxygen	171-173	coagulation factor II, thrombin	Homo sapiens	60-62
29560240-1	2015	Cytochrome P450 enzymes are heme based monoxygenases that catalyse a range of oxygen atom transfer reactions with various substrates, including aliphatic and aromatic hydroxylation as well as epoxidation reactions.	Oxygen	42-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
25463508-7	2015	The usage of the commercially available polymerization monomer of SBMA, the simple convenient synthesis process regardless of the presence of oxygen and the excellent controllability of e-siATRP make it a very promising and universal technique in the preparation of zwitterionic polymer coatings, especially in the development of biocompatible material for implantable devices such as neural and biosensor electrodes.	Oxygen	142-148	androgen receptor	Homo sapiens	66-70
25653067-6	2015	With these spirals, spatial gradients of 3-15 % oxygen were delivered to fibroblast cells seeded across a gas-permeable membrane to modulate VEGF secretions.	Oxygen	48-54	vascular endothelial growth factor A	Homo sapiens	141-145
25499849-0	2015	Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells.	Oxygen	8-14	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
24841383-7	2015	Moreover, IGF-1 effectively ameliorated O2 consumption and mitochondrial membrane potential (Deltapsim) in HD lymphoblasts, which occurred concomitantly with increased levels of cytochrome c.	Oxygen	40-42	insulin like growth factor 1	Homo sapiens	10-15
25534037-7	2015	Our results showed that exposure of hASC to human BMP7 was associated with significant escalation of (1) UCP1 gene expression, a signature gene of brown adipocytes, (2) beige specific marker gene expression (i.e., CD137 and TMEM26), (3) glucose and fatty acid uptake, and (4) basal and cAMP-stimulated oxygen consumption rate compared to white adipocyte control.	Oxygen	302-308	PYD and CARD domain containing	Homo sapiens	36-40
26040109-0	2015	Serum neuron-specific enolase and S-100beta levels as prognostic follow-up markers for oxygen administered carbon monoxide intoxication cases.	Oxygen	87-93	enolase 2	Homo sapiens	6-29
25973000-0	2015	Hyperbaric oxygen intervention reduces secondary spinal cord injury in rats via regulation of HMGB1/TLR4/NF-kappaB signaling pathway.	Oxygen	11-17	toll-like receptor 4	Rattus norvegicus	100-104
25973000-1	2015	BACKGROUND: To investigate whether hyperbaric oxygen (HBO) intervention affects the expressions of inflammatory cytokines, HMGB1/TLR4/NF-kappaB, and arrests secondary spinal cord injury (SCI).	Oxygen	46-52	toll-like receptor 4	Rattus norvegicus	129-133
25973000-11	2015	CONCLUSIONS: Hyperbaric oxygen reduced the expressions of HMGB1, TLR4, and NF-kappaB and reduced secondary SCI as measured using BBB scores.	Oxygen	24-30	toll-like receptor 4	Rattus norvegicus	65-69
25327972-4	2015	First, we performed two different hypoxia-like procedures in hCMEC/D3 cells; namely, exposition of cells to 150 muM deferoxamine or to glucose and oxygen deprivation for 6 h. These two procedures led to hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha proteins accumulation together with a significant induction of the two well-known hypoxia-inducible genes VEGF and GLUT-1.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	203-240
25374014-4	2015	In this study, an oxygen-induced retinopathy model was used to investigate the effects of reduced beta2GPI and beta2GPI, and to monitor the expression of VEGF, VEGF receptor (VEGFR) 1, VEGFR-2 and hypoxia-inducible factor 1 (HIF-1) mRNA and the phosphorylation of extracellular signal-regulated kinase (ERK) and Akt.	Oxygen	18-24	apolipoprotein H	Mus musculus	98-106
25022804-10	2015	Early oxygen therapies prevented occludin degradation, MMP-9 activation, and reduced HIF-1alpha expression.	Oxygen	6-12	occludin	Mus musculus	33-41
25327251-4	2015	Reductive dehalogenases form a distinct subfamily of cobalamin (B12)-dependent enzymes that are usually membrane associated and oxygen sensitive, hindering detailed studies.	Oxygen	128-134	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	64-67
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	vascular endothelial growth factor A	Homo sapiens	56-60
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	fibroblast growth factor 2	Homo sapiens	65-69
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	cyclin dependent kinase inhibitor 2A	Homo sapiens	171-174
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	tumor protein p53	Homo sapiens	181-184
25590809-3	2015	beta-Lap is bioactivated by NADPH:quinone oxidoreductase 1 (NQO1) in a futile redox cycle that consumes oxygen and generates high levels of reactive oxygen species (ROS) that cause extensive DNA damage and rapid PARP1-mediated NAD(+) consumption.	Oxygen	104-110	NAD(P)H quinone dehydrogenase 1	Homo sapiens	28-58
25058943-3	2015	As a mimetic of endogenous EPO (eEPO), rHuEPO augments the oxygen carrying capacity of blood.	Oxygen	59-65	erythropoietin	Homo sapiens	27-30
25561552-3	2015	Consequently, S-MIF is considered some of the strongest evidence for the lack of free atmospheric oxygen before 2.4 Ga.	Oxygen	98-104	decapping mRNA 1A	Homo sapiens	14-19
25590809-3	2015	beta-Lap is bioactivated by NADPH:quinone oxidoreductase 1 (NQO1) in a futile redox cycle that consumes oxygen and generates high levels of reactive oxygen species (ROS) that cause extensive DNA damage and rapid PARP1-mediated NAD(+) consumption.	Oxygen	104-110	NAD(P)H quinone dehydrogenase 1	Homo sapiens	60-64
25535359-6	2015	Our findings, supported by in vivo and clinical evidence, demonstrate a mechanism for oxygen-independent HIF-1 regulation, which has important implications for individualizing therapies in patients with cancer.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
25462371-5	2015	In the ISA, the beam reacts with O2 gas, selectively removing the BaF2- and leaving the Cs analyte to be reaccelerated and sent through the remainder of the AMS system.	Oxygen	33-35	BANF family member 2	Homo sapiens	66-70
25413349-0	2015	Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.	Oxygen	0-6	transient receptor potential cation channel subfamily V member 3	Homo sapiens	52-57
25413349-4	2015	Hypoxia, FIH inhibitors and mutation of asparagine 242 all potentiated TRPV3-mediated current, without altering TRPV3 protein levels, indicating that oxygen-dependent hydroxylation inhibits TRPV3 activity.	Oxygen	150-156	transient receptor potential cation channel subfamily V member 3	Homo sapiens	71-76
26002730-2	2015	CYP enzymes catalyze monooxygenation reactions by inserting one oxygen atom from O2 into an enormous number and variety of substrates.	Oxygen	25-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
26002730-2	2015	CYP enzymes catalyze monooxygenation reactions by inserting one oxygen atom from O2 into an enormous number and variety of substrates.	Oxygen	81-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
26002730-5	2015	CYP-mediated hydroxylations occur via a consensus H atom abstraction/oxygen rebound mechanism involving an initial abstraction by CpdI of a H atom from the substrate, generating a highly-reactive protonated Compound II (CpdII) intermediate (FeIV-OH) and a carbon-centered alkyl radical that rebounds onto the ferryl hydroxyl moiety to yield the hydroxylated substrate.	Oxygen	69-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
26002730-6	2015	CYP enzymes utilize hydroperoxides, peracids, perborate, percarbonate, periodate, chlorite, iodosobenzene and N-oxides as surrogate oxygen atom donors to oxygenate substrates via the shunt pathway in the absence of NAD(P)H/O2 and reduction-oxidation (redox) auxiliary proteins.	Oxygen	132-138	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
26002730-6	2015	CYP enzymes utilize hydroperoxides, peracids, perborate, percarbonate, periodate, chlorite, iodosobenzene and N-oxides as surrogate oxygen atom donors to oxygenate substrates via the shunt pathway in the absence of NAD(P)H/O2 and reduction-oxidation (redox) auxiliary proteins.	Oxygen	223-225	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
25351440-2	2015	The findings reported in this paper demonstrate that, in the early phase of apoptosis, glucose metabolism is enhanced, i.e. key proteins which internalize and metabolize glucose-glucose transporter, hexokinase and phosphofructokinase-are up-regulated, in concomitance with a parallel decrease in oxygen consumption by mitochondria and increase of L-lactate accumulation.	Oxygen	296-302	hexokinase 1	Homo sapiens	199-209
26233903-4	2015	CYP enzymes catalyze the oxygenation of an organic substrate and the simultaneous reduction of molecular oxygen.	Oxygen	25-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
25424768-3	2015	According to the most recent evidence, there is an overlap between osteoblastic and perivascular niches that affects HSC function involving mesenchymal stromal and endothelial cells and a gradient of oxygen regulated by hypoxia inducible factor (HIF)-1alpha.	Oxygen	200-206	hypoxia inducible factor 1 subunit alpha	Homo sapiens	220-257
26273614-5	2015	In order to show this, experiments directly targeting the activity of hypoxia-inducible factor-1 (HIF1), the complex mediating responses to oxygen deprivation, were performed.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-96
25997392-2	2015	Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated alpha subunits (HIF1A/HIF-1alpha or EPAS1/HIF-2alpha), and a constitutively expressed ARNT/HIF-1beta subunit, that serve as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-182
25997392-2	2015	Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated alpha subunits (HIF1A/HIF-1alpha or EPAS1/HIF-2alpha), and a constitutively expressed ARNT/HIF-1beta subunit, that serve as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-193
26738305-5	2015	VEGF-A synthesis linearly increased with FCS concentration both at 20% and 5% O2.	Oxygen	78-80	vascular endothelial growth factor A	Coturnix japonica	0-6
25447141-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a regulated subunit of the hypoxia-inducible factor 1 (HIF1), which functions as a key transcription factor in response to hypoxic stress by regulating genes involved in maintaining oxygen homeostasis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
25447141-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a regulated subunit of the hypoxia-inducible factor 1 (HIF1), which functions as a key transcription factor in response to hypoxic stress by regulating genes involved in maintaining oxygen homeostasis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
25447141-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a regulated subunit of the hypoxia-inducible factor 1 (HIF1), which functions as a key transcription factor in response to hypoxic stress by regulating genes involved in maintaining oxygen homeostasis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-101
25447141-1	2015	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a regulated subunit of the hypoxia-inducible factor 1 (HIF1), which functions as a key transcription factor in response to hypoxic stress by regulating genes involved in maintaining oxygen homeostasis.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-107
26273614-5	2015	In order to show this, experiments directly targeting the activity of hypoxia-inducible factor-1 (HIF1), the complex mediating responses to oxygen deprivation, were performed.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-102
25348671-9	2015	Our findings suggest that Oct-3/4-expressing glioblastoma cells have the ability to adapt to low-oxygen environments within tumor masses by promoting tumor angiogenesis through AKT-HIF1 pathway.	Oxygen	97-103	AKT serine/threonine kinase 1	Homo sapiens	177-180
26624507-4	2015	The best-known function of PHD2 is to mediate the oxygen-dependent degradation of the labile alpha-subunit of hypoxia-inducible factor (HIF).	Oxygen	50-56	egl-9 family hypoxia inducible factor 1	Homo sapiens	27-31
25006059-5	2015	PA1 and PA2 are internalised by endocytosis, result in efficient staining in primary neurons, astrocytes, and PC12 cells and multi-cellular aggregates, and allow for the monitoring of local O(2) levels on a time-resolved fluorescence plate reader and PLIM microscope.	Oxygen	190-194	Paxip1-associated glutamate-rich protein 1	Rattus norvegicus	0-3
25548969-0	2015	Pigment epithelium-derived factor regulates glutamine synthetase and l-glutamate/l-aspartate transporter in retinas with oxygen-induced retinopathy.	Oxygen	121-127	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	0-33
25197983-11	2015	We conclude that the therapeutic ability of ASC spheroids to stimulate angiogenesis in endothelial cells is affected by both culture size and oxygenation parameters, suggesting that, while ASC spheroids offer potential in the treatment of injured and ischemic tissues, careful consideration of culture size in respect to in vivo local oxygen tension will be necessary for optimal results.	Oxygen	142-148	PYD and CARD domain containing	Homo sapiens	44-47
26407140-7	2015	HIF-1alpha displayed transient up-regulation, with maximum levels 30 min after acute hypoxic exposure, while HIF-3alpha was significantly up-regulated after 24 h. Up-regulation of ERK7, MEK1 and c-fos, and down-regulation of MKK6, p53, CCNA2, CCNB1 and CCNB2 were observed after 24 h of oxygen deprivation.	Oxygen	287-293	hypoxia inducible factor 3 subunit alpha	Homo sapiens	109-119
23514971-2	2015	This study examined the relationship between hematocrit, blood viscosity, plasma viscosity, erythrocyte deformability, and fibrinogen concentration during maximal oxygen uptake in aerobically trained (AT) and resistance trained (RT) athletes.	Oxygen	163-169	fibrinogen beta chain	Homo sapiens	123-133
26279426-6	2015	RESULTS: Elevated levels of IL-1beta, alphavbeta6 and TGF-beta1 were each associated with aberrant elastin production in O2-exposed lungs.	Oxygen	121-123	interleukin 1 beta	Mus musculus	28-36
25548969-0	2015	Pigment epithelium-derived factor regulates glutamine synthetase and l-glutamate/l-aspartate transporter in retinas with oxygen-induced retinopathy.	Oxygen	121-127	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	44-64
25548969-0	2015	Pigment epithelium-derived factor regulates glutamine synthetase and l-glutamate/l-aspartate transporter in retinas with oxygen-induced retinopathy.	Oxygen	121-127	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	69-104
26728723-3	2015	FZD1, FZD3, SFRP1, and SFRP4 genes were up-regulated after short-term hypoxic stress (0.1% O2), whereas the expression of LEF-1 and RUVBL1 genes was significantly inhibited (down-regulated).	Oxygen	91-93	secreted frizzled related protein 4	Homo sapiens	23-28
25968948-12	2015	CONCLUSION: Insulin stimulated the expression of miR-210 through the PI3K/Akt pathway, resulting in a protective effect against cardiomyocyte injury that had been induced by H2O2/oxygen species.	Oxygen	179-185	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
25453601-12	2015	CONCLUSIONS: The data on reduced oxygen consumption and altered calcium homeostasis obtained on mutant fibroblasts are the first evidences, in physiological conditions, of a mitochondrial dysfunction in PNKD.	Oxygen	33-39	PNKD metallo-beta-lactamase domain containing	Homo sapiens	203-207
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	57-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	73-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	73-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
25447307-8	2015	Consequently, viability of cells deprived of O2 and glucose decreased upon inhibition of AMPK with dorsomorphin.	Oxygen	45-47	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	89-93
26400662-6	2015	In this paper, we address the evolution of tetracobalt(III) cubanes, stabilised by a pyridine/acetate ligand pool, to active species that perform water oxidation to oxygen.	Oxygen	165-171	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	55-58
26400662-9	2015	A more accentuated evolution occurs under continuous irradiation, where Electron Paramagnetic Resonance (EPR) spectroscopy reveals the formation of Co(ii) intermediates, likely contributing to the catalytic process that evolves oxygen.	Oxygen	228-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
26037200-7	2015	Data show that ERRalpha exerts its metabolic control by regulating the expression of SIRT5 that influences oxygen consumption and ATP generation.	Oxygen	107-113	estrogen related receptor alpha	Homo sapiens	15-23
24806737-3	2015	Ten elite male cross-country skiers (mean +- SD; 28.2 +- 5.4 y, 181 +- 8 cm, 77.9 +- 9.4 kg, 69.5 +- 4.3 mL   min-1   kg-1 maximal oxygen uptake [VO2max]) performed 2 sessions of roller-skiing on a treadmill: a 2 x 3-km time trial and the same 6-km at an imposed submaximal speed followed by a final 800-m time trial.	Oxygen	131-137	CD59 molecule (CD59 blood group)	Homo sapiens	110-122
25395666-3	2015	The precise functionality of these neurons is specified by the coexpression of a membrane-bound receptor-type guanylyl cyclase GCY-9 that is required for responses to CO2 upshifts and the soluble guanylyl cyclases GCY-31 and GCY-33 that mediate responses to downshifts in O2.	Oxygen	168-170	Receptor-type guanylate cyclase gcy-9	Caenorhabditis elegans	127-132
25841134-3	2015	This study utilized a model of continuously contracting adult cardiomyocytes to determine the effects of sustained oxygen reduction (hypoxia) on ERRalpha target gene expression.	Oxygen	115-121	estrogen related receptor alpha	Homo sapiens	145-153
26370867-4	2015	His P50 value was mildly decreased, thus we suspected the presence of an Hb variant with a high oxygen affinity.	Oxygen	96-102	nuclear factor kappa B subunit 1	Homo sapiens	4-7
26823030-7	2015	hs-cTnT was significantly correlated with advanced glycation end-product levels at the skin (r=0.23, p&lt;0.001), blood concentrations of brain natriuretic peptide (r=0.23, p&lt;0.001), reactive oxygen metabolites as markers of oxidative stress (r=0.28, p&lt;0.001), and the augmentation index at the radial artery as marker of arterial reflection (r=0.31, p&lt;0.001).	Oxygen	195-201	troponin T2, cardiac type	Homo sapiens	3-7
25590838-9	2015	In laboratory experiments, metabolic heterogeneity in oxygen consumption, extracellular acidification rates (ECARs), and amounts of OxPhos complexes were consistently observed in BCPAP, TPC1, HTH-7, and XTC.UC1 cell lines.	Oxygen	54-60	two pore segment channel 1	Homo sapiens	186-190
25259652-5	2015	Recombinant erythropoietin treatment increased mitochondrial O2 flux during ADP stimulated state 3 respiration in the presence of complex I and II substrates (malate, glutamate, pyruvate, succinate) with additional electron input from beta-oxidation (octanoylcarnitine) (from 60 +- 13 to 87 +- 24 pmol   s(-1)   mg(-1) P &lt; 0.01).	Oxygen	61-63	erythropoietin	Homo sapiens	12-26
26031822-3	2015	Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum.	Oxygen	121-127	interleukin 6	Homo sapiens	172-179
26031822-3	2015	Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum.	Oxygen	121-127	fibroblast growth factor 2	Homo sapiens	213-217
25370750-0	2015	A quinol oxidase, encoded by cyoABCD, is utilized to adapt to lower O2 concentrations in Rhizobium etli CFN42.	Oxygen	68-70	DoxX family protein	Rhizobium etli CFN 42	2-16
25878404-0	2015	Oxygen-Loaded Nanodroplets Effectively Abrogate Hypoxia Dysregulating Effects on Secretion of MMP-9 and TIMP-1 by Human Monocytes.	Oxygen	0-6	TIMP metallopeptidase inhibitor 1	Homo sapiens	104-110
25861159-6	2015	Deletion of AMPKalpha1 in the mixed glial cells of Abcd1-KO mice induced spontaneous mitochondrial dysfunction (lower oxygen consumption rate and ATP levels).	Oxygen	118-124	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	12-22
25444347-5	2015	Based on studies in animal models of oxygen-induced retinopathy (OIR), exogenous factors such as oxygen levels, oxidative stress, inflammation, and nutritional capacity have been linked to severe ROP through dysregulated signaling pathways involving hypoxia-inducible factors and angiogenic factors like VEGF, oxidative species, and neuroprotective growth factors to cause phases of ROP.	Oxygen	37-43	vascular endothelial growth factor A	Homo sapiens	304-308
26613578-5	2015	RESULTS: TGFbeta treatment in podocytes induced a significant Smad-dependent increase of mitochondrial oxygen consumption rate (OCR).	Oxygen	103-109	transforming growth factor beta 1	Homo sapiens	9-16
25444347-5	2015	Based on studies in animal models of oxygen-induced retinopathy (OIR), exogenous factors such as oxygen levels, oxidative stress, inflammation, and nutritional capacity have been linked to severe ROP through dysregulated signaling pathways involving hypoxia-inducible factors and angiogenic factors like VEGF, oxidative species, and neuroprotective growth factors to cause phases of ROP.	Oxygen	97-103	vascular endothelial growth factor A	Homo sapiens	304-308
26265981-6	2015	Oxygen/O3 dose-dependently increased the expression of the antioxidant enzymes Mn-SOD and GPx1 and of eNOS compared to the exercised O2 rats.	Oxygen	0-6	glutathione peroxidase 1	Rattus norvegicus	90-94
25447041-12	2015	CONCLUSION: This human cadaver study demonstrates that continuous oxygen insufflation induced less gastric inflation than intermittent insufflation during CPR.	Oxygen	66-72	cytochrome p450 oxidoreductase	Homo sapiens	155-158
26417938-3	2015	By employing the purified proteins of horseradish peroxidase as a model, we have recently proposed a likely role for free Fe(2+) in reduction of ferric enzyme of plant peroxidases into ferrous intermediate and oxygen-bound form of enzyme known as Compound III which may eventually releases superoxide anion radical (O2( -)), especially under alkaline condition, possibly contributing to the plant defense mechanism.	Oxygen	210-216	peroxidase	Glycine max	50-60
26417938-3	2015	By employing the purified proteins of horseradish peroxidase as a model, we have recently proposed a likely role for free Fe(2+) in reduction of ferric enzyme of plant peroxidases into ferrous intermediate and oxygen-bound form of enzyme known as Compound III which may eventually releases superoxide anion radical (O2( -)), especially under alkaline condition, possibly contributing to the plant defense mechanism.	Oxygen	316-318	peroxidase	Glycine max	50-60
25868435-7	2015	Interestingly, we also found that ischemic per- and post-conditioning significantly increased expression of Ngb, an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke, at peri-infarct regions from day 1 to day 14 following ischemia/reperfusion.	Oxygen	116-122	neuroglobin	Rattus norvegicus	108-111
25791185-8	2015	Furthermore, there was an increase in peak oxygen con-sumption (1.7 ml O2 kg-1 min-1; CI95%: 0.1 to 3.3, P &lt; 0.05) and muscular strength (P &lt; 0.001).	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	79-84
25526634-0	2014	The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.	Oxygen	120-126	purinergic receptor P2Y1	Rattus norvegicus	37-41
25587028-2	2014	Concurrent attenuation of oxidative phosphorylation and HIF-1alpha/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and oxygen-dependent cell death that we term ferroxitosis.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
25531909-8	2014	Additionally, tumor necrosis factor-alpha and interleukin-10 mRNA expression levels were significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury.	Oxygen	140-146	tumor necrosis factor	Rattus norvegicus	14-41
25301896-7	2014	These findings suggest that the NO3 (-)-NO2 (-)-NO pathway is a significant modulator of muscle energetics and O2 delivery during hypoxic exercise and subsequent recovery.	Oxygen	41-43	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
25513814-3	2014	Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
25513814-3	2014	Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-40
25496056-1	2014	BACKGROUND: HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that functions as a critical regulator of oxygen homeostasis.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-17
25496056-1	2014	BACKGROUND: HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that functions as a critical regulator of oxygen homeostasis.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-45
25517035-3	2014	The reduction of BFXs by both P-450R and NQO1 was accompanied by O2 uptake, which was much lower than the NADPH oxidation rate; except for annelated BFXs, whose reduction was followed by the production of peroxide.	Oxygen	65-67	cytochrome p450 oxidoreductase	Homo sapiens	30-36
25517035-3	2014	The reduction of BFXs by both P-450R and NQO1 was accompanied by O2 uptake, which was much lower than the NADPH oxidation rate; except for annelated BFXs, whose reduction was followed by the production of peroxide.	Oxygen	65-67	NAD(P)H quinone dehydrogenase 1	Homo sapiens	41-45
25510649-11	2014	Expression of MMP13 was reduced at 2% oxygen tension in control cells.	Oxygen	38-44	matrix metallopeptidase 13	Homo sapiens	14-19
25510649-12	2014	Relative expression of MMP13 increased in cells stimulated with IL-1beta and 5-aza-dC in normoxic conditions, and this effect was eliminated at low oxygen tension although no correlation with methylation status was observed.	Oxygen	148-154	matrix metallopeptidase 13	Homo sapiens	23-28
25361009-4	2014	Here, we show that phospholipase D1 (PLD1) protein itself acts as a molecular platform, interacting directly with HIF-1alpha, PHD, and VHL, thereby dynamically assembling a multiprotein complex that mediates efficient degradation of HIF-1alpha in an O2-dependent manner.	Oxygen	250-252	phospholipase D1	Homo sapiens	19-35
25361009-4	2014	Here, we show that phospholipase D1 (PLD1) protein itself acts as a molecular platform, interacting directly with HIF-1alpha, PHD, and VHL, thereby dynamically assembling a multiprotein complex that mediates efficient degradation of HIF-1alpha in an O2-dependent manner.	Oxygen	250-252	phospholipase D1	Homo sapiens	37-41
25361009-4	2014	Here, we show that phospholipase D1 (PLD1) protein itself acts as a molecular platform, interacting directly with HIF-1alpha, PHD, and VHL, thereby dynamically assembling a multiprotein complex that mediates efficient degradation of HIF-1alpha in an O2-dependent manner.	Oxygen	250-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
25324517-1	2014	Cytochrome c oxidase is the enzyme responsible for oxygen consumption by mitochondrial oxidative phosphorylation and coupling site 3 of oxidative phosphorylation.	Oxygen	51-57	cytochrome c, somatic	Homo sapiens	0-12
25361009-4	2014	Here, we show that phospholipase D1 (PLD1) protein itself acts as a molecular platform, interacting directly with HIF-1alpha, PHD, and VHL, thereby dynamically assembling a multiprotein complex that mediates efficient degradation of HIF-1alpha in an O2-dependent manner.	Oxygen	250-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	233-243
25361009-7	2014	Interestingly, the pleckstrin homology domain interacting with these proteins promoted degradation of HIF-1alpha independent of oxygen concentration and suppressed tumor progression.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
25324517-3	2014	Four electrons are required for the reduction of oxygen to water, and these are provided by the one-electron donor, cytochrome c.	Oxygen	49-55	cytochrome c, somatic	Homo sapiens	116-128
25324517-4	2014	The rate of oxygen consumption (ATP synthesis) is dependent on the fraction of cytochrome c reduced (fred), oxygen pressure (pO2), energy state ([ATP]/[ADP][Pi]), and pH.	Oxygen	12-18	cytochrome c, somatic	Homo sapiens	79-91
25324518-3	2014	In addition, neither the mechanism of oxygen reduction by mitochondrial cytochrome c oxidase nor how its rate is controlled is understood, although this enzyme determines the rate of oxygen consumption and thereby the rate of ATP synthesis.	Oxygen	38-44	cytochrome c, somatic	Homo sapiens	72-84
25324518-3	2014	In addition, neither the mechanism of oxygen reduction by mitochondrial cytochrome c oxidase nor how its rate is controlled is understood, although this enzyme determines the rate of oxygen consumption and thereby the rate of ATP synthesis.	Oxygen	183-189	cytochrome c, somatic	Homo sapiens	72-84
25324518-4	2014	Cytochrome c oxidase is responsible for reduction of molecular oxygen to water using reducing equivalents donated by cytochrome c and for site 3 energy coupling in oxidative phosphorylation.	Oxygen	63-69	cytochrome c, somatic	Homo sapiens	0-12
25324518-4	2014	Cytochrome c oxidase is responsible for reduction of molecular oxygen to water using reducing equivalents donated by cytochrome c and for site 3 energy coupling in oxidative phosphorylation.	Oxygen	63-69	cytochrome c, somatic	Homo sapiens	117-129
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Oxygen	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
25399573-6	2014	For example, the pro-angiogenic VEGFA is secreted by cells in need of oxygen, presented to the basal side of the endothelium, whereas BMP9 and BMP10 are supplied via the bloodstream in constant interaction with the apical side to suppress angiogenesis.	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	32-37
25505325-9	2014	PDL-1 promotes localization of GCY-33 and GCY-35, atypical soluble guanylate cyclases that act as O2 sensors, to the dendritic endings of URX and BAG neurons, where they colocalize with GLB-5.	Oxygen	98-100	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	42-48
25407895-3	2014	DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates.	Oxygen	30-35	D site albumin promoter binding protein	Mus musculus	0-3
25407895-3	2014	DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates.	Oxygen	30-35	D site albumin promoter binding protein	Mus musculus	175-178
25407895-3	2014	DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates.	Oxygen	144-149	D site albumin promoter binding protein	Mus musculus	0-3
25407895-3	2014	DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates.	Oxygen	144-149	D site albumin promoter binding protein	Mus musculus	175-178
25301764-0	2014	Effective CPR at high altitudes likely requires oxygen-supplemented continuous abdominal compressions.	Oxygen	48-54	cytochrome p450 oxidoreductase	Homo sapiens	10-13
25399601-3	2014	Additionally, BiP is a member of the heat-shock protein (HSP) 70 family and, as a stress protein, is up-regulated by conditions of reduced oxygen and glucose.	Oxygen	139-145	heat shock protein 5	Mus musculus	14-17
25399601-3	2014	Additionally, BiP is a member of the heat-shock protein (HSP) 70 family and, as a stress protein, is up-regulated by conditions of reduced oxygen and glucose.	Oxygen	139-145	heat shock protein 1B	Mus musculus	37-64
25320003-0	2014	Mesoporous TiN as a noncarbon support of Ag-rich PtAg nanoalloy catalysts for oxygen reduction reaction in alkaline media.	Oxygen	78-84	rhomboid domain containing 3	Homo sapiens	49-53
24963048-8	2014	In pancreatic cancer cells, inhibition of functional p38 by SB202190 increased cell proliferation in vitro in both low-serum and low-oxygen conditions.	Oxygen	133-139	mitogen-activated protein kinase 14	Homo sapiens	53-56
25172885-0	2014	Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. High-altitude natives are challenged by hypoxia, and a potential compensatory mechanism could be reduced blood oxygen-binding affinity (P50), as seen in several high-altitude mammalian species.	Oxygen	199-205	nuclear factor kappa B subunit 1	Homo sapiens	224-227
25355043-1	2014	The transcription factor HIF-1alpha is essential for cells to rapidly adapt to low oxygen levels (hypoxia).	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
25172885-1	2014	In 21 Qinghai Tibetan and nine Han Chinese men, all resident at 4200 m, standard P50 was calculated from measurements of arterial PO2 and forehead oximeter oxygen saturation, which was validated in a separate examination of 13 healthy subjects residing at sea level.	Oxygen	156-162	nuclear factor kappa B subunit 1	Homo sapiens	81-84
25172885-0	2014	Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. High-altitude natives are challenged by hypoxia, and a potential compensatory mechanism could be reduced blood oxygen-binding affinity (P50), as seen in several high-altitude mammalian species.	Oxygen	16-22	nuclear factor kappa B subunit 1	Homo sapiens	224-227
25224641-0	2014	Self-oxidation of cytochrome c at methionine80 with molecular oxygen induced by cleavage of the Met-heme iron bond.	Oxygen	62-68	cytochrome c, somatic	Homo sapiens	18-30
25065497-8	2014	These data indicate that TRPM8-induced increase of HIF-1alpha protein in hypoxia- or normoxia-exposed prostate cancer cells was mediated through a newly characterized Ca(2+) -dependent but O2 -independent mechanism involving binding of RACK1 to HIF-1alpha and RACK1-mediated ubiquitination of HIF-1alpha.	Oxygen	189-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
25971106-3	2014	An Oxygen-Hydrogen plasma treatment process is performed to remove OSP material.	Oxygen	3-9	claudin 11	Homo sapiens	67-70
25245610-8	2014	We show that the dynamics of HIF-1alpha and transcriptional targets of HIF-1alpha display a non-monotone response to the oxygen dynamics.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
25245610-8	2014	We show that the dynamics of HIF-1alpha and transcriptional targets of HIF-1alpha display a non-monotone response to the oxygen dynamics.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
25537043-4	2014	Two systems are investigated: human macrophages subjected to lipopolysaccharide challenge, analogous to the immune response against Gram-negative bacteria and the response of the proteins involved in the mTOR signalizing network of GBM cancer cells to changes in partial oxygen pressure.	Oxygen	271-277	mechanistic target of rapamycin kinase	Homo sapiens	204-208
25224641-2	2014	We found that the mass of human cyt c increases by 16 Da in the Met80-Lys86 region by reaction with molecular oxygen in the presence of CL-containing liposomes and dithiothreitol (DTT).	Oxygen	110-116	cytochrome c, somatic	Homo sapiens	32-37
25269825-1	2014	This study aimed to investigate the effect and potential mechanisms of exogenous administration of recombinant human erythropoietin (rhEPO) on retinal angiogenesis in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	184-190	erythropoietin	Homo sapiens	117-131
25224641-3	2014	To investigate the effect of Met80 dissociation on the reaction of cyt c with molecular oxygen without affecting its secondary structures, a human cyt c mutant (Delta8384 cyt c) was constructed by removing two amino acids (Val83 and Gly84) from the loop containing Met80.	Oxygen	88-94	cytochrome c, somatic	Homo sapiens	67-72
25224641-4	2014	According to MALDI-TOF-MS and tandem mass measurements, Met80 of Delta8384 cyt c was modified site-specifically to methionine sulfoxide when purified in the presence of molecular oxygen, whereas Met80 was not modified in the absence of molecular oxygen.	Oxygen	179-185	cytochrome c, somatic	Homo sapiens	75-80
25224641-4	2014	According to MALDI-TOF-MS and tandem mass measurements, Met80 of Delta8384 cyt c was modified site-specifically to methionine sulfoxide when purified in the presence of molecular oxygen, whereas Met80 was not modified in the absence of molecular oxygen.	Oxygen	246-252	cytochrome c, somatic	Homo sapiens	75-80
25224641-5	2014	A red-shift of the Soret band from 406 to 412 nm and absorption increase at ~536 and ~568 nm were observed for Delta8384 cyt c when it reacted with DTT and molecular oxygen, followed by a further red-shift of the Soret band to 416 nm and absorption increase at ~620 and ~650 nm.	Oxygen	166-172	cytochrome c, somatic	Homo sapiens	121-126
25293376-9	2014	Low oxygen supply upregulated CXCR4, CCR7 and CXCR6, but downregulated CXCL12 and CCR1.	Oxygen	4-10	C-C motif chemokine receptor 7	Homo sapiens	37-41
25152242-8	2014	In addition, a reactive oxygen-eliminating enzyme, Mn-SOD, was observed only in prehypertrophic chondrocytes at 3 weeks of age, and not detected in osteoblasts.	Oxygen	24-30	superoxide dismutase 2, mitochondrial	Mus musculus	51-57
24510497-10	2014	Fibrinogen levels were directly related to AHI and arousal index and inversely related to mean and lowest oxygen saturation during sleep.	Oxygen	106-112	fibrinogen beta chain	Homo sapiens	0-10
24510497-11	2014	CONCLUSIONS: Severity of OSA was associated with increased fibrinogen level independent of other factors, suggesting that apneic events and oxygen desaturation during sleep are mechanisms for increased fibrinogen levels in patients with OSA.	Oxygen	140-146	fibrinogen beta chain	Homo sapiens	59-69
24510497-11	2014	CONCLUSIONS: Severity of OSA was associated with increased fibrinogen level independent of other factors, suggesting that apneic events and oxygen desaturation during sleep are mechanisms for increased fibrinogen levels in patients with OSA.	Oxygen	140-146	fibrinogen beta chain	Homo sapiens	202-212
25168373-10	2014	At 6, 12, 24, and 36 h following hypoxia, CCR7 and HIF-1alpha proteins were both obviously upregulated in a time-dependent method, compared with normal oxygen.	Oxygen	152-158	C-C motif chemokine receptor 7	Homo sapiens	42-46
25876351-5	2014	RESULTS: Acupunc- ture at Taichong (LR 3) in EH patients mainly increased opposite-side oxygen consumption, which generally activated left anterior cingulated gyrus (BA 32), left inferior parietal lobule (BA 40), left inferior temporal gyrus (BA 19), left middle temporal gyrus (BA 37) and right anterior central gyrus (BA 6).	Oxygen	88-94	LDL receptor related protein 5	Homo sapiens	36-40
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Oxygen	123-131	nitric oxide synthase 2	Homo sapiens	0-31
25621297-7	2014	Our results suggest that MEK inhibition may be a strategy for triggering cell death within the hypoperfused, oxygen and nutrient poor regions of tumors with activated RAS alleles.	Oxygen	109-115	mitogen-activated protein kinase kinase 7	Homo sapiens	25-28
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Oxygen	123-131	nitric oxide synthase 2	Homo sapiens	33-37
25356789-4	2014	Significantly, the inhibitory effect of the probes on HIF-1alpha activity was consistent with that of the MDH2 enzyme assay, which was further confirmed by the effect on in vitro binding activity to recombinant human MDH2, oxygen consumption, ATP production, and AMP activated protein kinase (AMPK) activation.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
25431923-0	2014	Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.	Oxygen	20-26	egl-9 family hypoxia inducible factor 1	Homo sapiens	35-40
25431923-1	2014	Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-alpha inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1alpha, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).	Oxygen	8-14	egl-9 family hypoxia inducible factor 1	Homo sapiens	24-42
25431923-1	2014	Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-alpha inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1alpha, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).	Oxygen	8-14	egl-9 family hypoxia inducible factor 1	Homo sapiens	44-49
25431923-1	2014	Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-alpha inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1alpha, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
25418722-6	2014	Furthermore, our data show that even transient changes in O2 concentration can affect cell fate through HIF by regulating the activity of MYC, a regulator of LIN28/let-7 that is critical for fate decisions in the neural lineage.	Oxygen	58-60	lin-28 homolog A	Homo sapiens	158-163
25251247-0	2014	Nef reaction with molecular oxygen in the absence of metal additives, and mechanistic insights.	Oxygen	28-34	S100 calcium binding protein B	Homo sapiens	0-3
25251247-1	2014	A Nef reaction has been developed that is conducted under mildly basic conditions with molecular oxygen as an oxidant, without the need for metal additives.	Oxygen	97-103	S100 calcium binding protein B	Homo sapiens	2-5
25251247-2	2014	Whereas nitroalkanes are converted into ketones in good yield, nitroalkenes are transformed into alpha,beta-unsaturated ketones in one-pot by double-bond isomerization followed by the oxygen-mediated Nef reaction.	Oxygen	184-190	S100 calcium binding protein B	Homo sapiens	200-203
25412154-5	2014	NO3- supplementation (either as BRJ or sodium nitrate [NaNO3-]) has also demonstrated modest benefits pertaining to cardiovascular health, such as reducing blood pressure (BP), enhancing blood flow, and elevating the driving pressure of O2 in the microcirculation to areas of hypoxia or exercising tissue.	Oxygen	237-239	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
27774475-3	2014	HIF-1alpha, a master transcription factor of oxygen homeostasis, induces inflammation and insulin resistance in obesity, whereas its isoform, HIF-2alpha, exerts opposing functions in these obesity-associated metabolic phenotypes.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
24607784-5	2014	MAIN METHODS: Using Western blotting assay and a reporter gene containing the HIF-1alpha oxygen-dependent degradation domain we monitored the capacity of ET-1 to increase HIF-1alpha and HIF-2alpha stability and nuclear accumulation.	Oxygen	89-95	endothelin 1	Homo sapiens	154-158
25401928-12	2014	Finally, hypoxia (0% oxygen) down-regulates ELK3 mRNA in a microRNA and hsa-miR-155-5p dependent manner.	Oxygen	21-27	ETS transcription factor ELK3	Homo sapiens	44-48
25392999-1	2014	Oxygen sensing by hypoxia-inducible factor prolyl hydroxylases (HIF-PHs) is the dominant regulatory mechanism of erythropoietin (EPO) expression.	Oxygen	0-6	erythropoietin	Homo sapiens	113-127
25392999-1	2014	Oxygen sensing by hypoxia-inducible factor prolyl hydroxylases (HIF-PHs) is the dominant regulatory mechanism of erythropoietin (EPO) expression.	Oxygen	0-6	erythropoietin	Homo sapiens	129-132
25368913-5	2014	Furthermore, the siRNA was released from the FRS-NPs in the cells and knocked down ICAM-1 expression in the TNF-alpha-stimulated cells and in the cells under oxygen-glucose deprivation/reoxygenation (OGD/R) condition.	Oxygen	158-164	tumor necrosis factor	Mus musculus	108-117
25385697-7	2014	We observe that this interaction between excess Fe, ferritin and RSA is in part mediated by the H2O2/O2.- balance between the root cell proliferation and differentiation zones regulated by the UPB1 transcription factor.	Oxygen	98-100	transcription factor UPBEAT protein	Arabidopsis thaliana	193-197
25383028-4	2014	Correspondingly, oxygen diffusivity is higher in pure UO2 than in pure ThO2.	Oxygen	17-23	THO complex 2	Homo sapiens	71-75
25376904-8	2014	This resulted in a reduction in mitochondrial Ca(2+) uptake, Akt activation, glucose uptake and oxygen consumption in response to insulin.	Oxygen	96-102	insulin	Homo sapiens	130-137
25218903-7	2014	Levels of Nrf2 (P&lt;0.01) in peripheral blood mononuclear cells (PBMC) were found to increase immediately after ozone/oxygen exposure (35microg/ml, prior to reinfusion).	Oxygen	119-125	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
25365359-5	2014	These phenotypes are suppressed by treatment with selective Rho-kinase inhibitor, associated with increased whole body O2 consumption and AMPK activation in the skeletal muscle and liver.	Oxygen	119-121	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	60-70
25440060-2	2014	Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1alpha and Hif-2alpha) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-alpha signaling.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
25064694-7	2014	These findings indicate that a small drop in oxygen tension up-regulates SUR2A in the heart by activating ERK signaling pathway.	Oxygen	45-51	mitogen-activated protein kinase 1	Mus musculus	106-109
26019598-7	2014	eNOS is a subgroup of this family of enzymes that catalyses the production of nitric oxide (NO) from L-arginine and oxygen, which leads to vascular relaxation by activating the guanylate cyclase.	Oxygen	116-122	nitric oxide synthase 3	Homo sapiens	0-4
25618118-15	2014	Thus, the effect of sevoflurane was useful for maintaining cerebral oxygen saturation during CBP.	Oxygen	68-74	CREB binding protein	Homo sapiens	93-96
24998603-9	2014	In xenografts in mice exposed to hypoxia (10% O2) for 21days, tumour necrosis was significantly increased by knocking down gastrin expression.	Oxygen	46-48	gastrin	Mus musculus	123-130
25120187-3	2014	Transient kinetic studies have shown that purified PHD2 reacts slowly with O2 compared with some other studied 2OG oxygenases, a property which may be related to its hypoxia-sensing role.	Oxygen	75-77	egl-9 family hypoxia inducible factor 1	Homo sapiens	51-55
25120187-4	2014	PHD2 forms a stable complex with Fe(II) and 2OG; crystallographic and kinetic analyses indicate that an Fe(II)-co-ordinated water molecule, which must be displaced before O2 binding, is relatively stable in the active site of PHD2.	Oxygen	171-173	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
25120187-4	2014	PHD2 forms a stable complex with Fe(II) and 2OG; crystallographic and kinetic analyses indicate that an Fe(II)-co-ordinated water molecule, which must be displaced before O2 binding, is relatively stable in the active site of PHD2.	Oxygen	171-173	egl-9 family hypoxia inducible factor 1	Homo sapiens	226-230
25120187-5	2014	We used active site substitutions to investigate whether these properties are related to the slow reaction of PHD2 with O2.	Oxygen	120-122	egl-9 family hypoxia inducible factor 1	Homo sapiens	110-114
24521195-1	2014	OBJECTIVES: This study aimed to compare the levels of plasma B-type natriuretic peptide (BNP) and C-reactive protein (CRP) in relation to oxygen transport between patients with restrictive right ventricle (rRV) and those without (non-rRV) early after tetralogy of Fallot (TOF) repair.	Oxygen	138-144	C-reactive protein	Homo sapiens	118-121
24610641-3	2014	We found that expression of the tumor-promoting cytokines, IL-8 and VEGF, induced by hypoxia (&lt;1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARdelta-deficient HCT116 colon cancer cells.	Oxygen	101-103	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
25111015-3	2014	We have recently found that FlaOHs inhibit catalase, the heme enzyme which catalyzes the decomposition of hydrogen peroxide (H2O2) into water and molecular oxygen.	Oxygen	156-162	catalase	Homo sapiens	43-51
25036722-6	2014	BCRP substrate specificity is quite low as it interacts with a spectrum of substances with only a few common features: hydrophobic and aromatic regions, possibly a flat conformation and the metal ion-, oxygen- and nitrogen-containing functionalities, most of which may be the donors/acceptors of H-bonds.	Oxygen	202-208	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
25236749-7	2014	Omission of superoxide dismutase (SOD) reduced by half the GSNO yield in the absence of Mg(2+), demonstrating O2(-) formation.	Oxygen	110-112	superoxide dismutase 1	Homo sapiens	12-32
25236749-7	2014	Omission of superoxide dismutase (SOD) reduced by half the GSNO yield in the absence of Mg(2+), demonstrating O2(-) formation.	Oxygen	110-112	superoxide dismutase 1	Homo sapiens	34-37
24610641-3	2014	We found that expression of the tumor-promoting cytokines, IL-8 and VEGF, induced by hypoxia (&lt;1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARdelta-deficient HCT116 colon cancer cells.	Oxygen	101-103	vascular endothelial growth factor A	Homo sapiens	68-72
25239494-9	2014	At all tested O2 levels, FGF4 maintained Warburg metabolism; mitochondrial inactivity and aerobic glycolysis.	Oxygen	14-16	fibroblast growth factor 4	Mus musculus	25-29
25365937-7	2014	Neonatal mice at postnatal day 7 (P7) were exposed to 75% concentration of oxygen for 5 days (P7-P12), and then returned to room air from P12 to P17 to induce retinal neovascularization.	Oxygen	75-81	polymerase (DNA-directed), delta 4	Mus musculus	97-100
24713588-6	2014	For PAVM patients, the age-adjusted pulse rise was 0.79 min(-1) greater for every 1% greater drop in oxygen saturation on standing (p&lt;0.001).	Oxygen	101-107	CD59 molecule (CD59 blood group)	Homo sapiens	56-62
25338163-0	2014	Role of compartmentalization on HiF-1alpha degradation dynamics during changing oxygen conditions: a computational approach.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
25598372-9	2014	The expressions of ER alpha in OSAHS patients showed positively correlated trends with the patients" lowest oxygen saturation.	Oxygen	108-114	estrogen receptor 1	Homo sapiens	19-27
25252141-3	2014	Incubation of purified aromatase with its 19-deutero-19-oxo androgen substrate was performed in the presence of (18)O2, and the products were derivatized using a novel diazo reagent.	Oxygen	116-118	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	23-32
25351418-5	2014	We show that DICER expression is suppressed by hypoxia through an epigenetic mechanism that involves inhibition of oxygen-dependent H3K27me3 demethylases KDM6A/B and results in silencing of the DICER promoter.	Oxygen	115-121	lysine demethylase 6A	Homo sapiens	154-159
25351853-2	2014	Amyloid-beta (Abeta), a key pathogenic factor in this disease, has potent cerebrovascular effects that contribute to brain dysfunction underlying dementia by limiting the delivery of oxygen and glucose to the working brain.	Oxygen	183-189	amyloid beta precursor protein	Homo sapiens	14-19
25196843-1	2014	Heme oxygenase (HO) catalyzes the rate-limiting step in the O2-dependent degradation of heme to biliverdin, CO, and iron with electrons delivered from NADPH via cytochrome P450 reductase (CPR).	Oxygen	60-62	cytochrome p450 oxidoreductase	Homo sapiens	161-186
25196843-1	2014	Heme oxygenase (HO) catalyzes the rate-limiting step in the O2-dependent degradation of heme to biliverdin, CO, and iron with electrons delivered from NADPH via cytochrome P450 reductase (CPR).	Oxygen	60-62	cytochrome p450 oxidoreductase	Homo sapiens	188-191
25061917-5	2014	TD-1 induced a greater increase in oxygen affinity of human hemoglobin in solution and in red blood cells than did 5-hydroxymethyl-2-furfural (5-HMF), N-ethylmaleimide (NEM), or diformamidine disulfide.	Oxygen	35-41	TLX1 neighbor	Homo sapiens	0-4
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	217-223	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	272-278	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	272-278	interleukin 1 beta	Homo sapiens	70-92
29123689-2	2015	The present study was carried out to compare the effect of administration of exogenous PGE1 with that of IL-1beta on oxygen metabolism.	Oxygen	117-123	interleukin-1 beta	Oryctolagus cuniculus	105-113
29123689-8	2015	Conclusion: These results indicate that simple vasodilation and hypotension induced by administration of PGE1 are insufficient to account for the abnormal oxygen metabolism induced by IL-1beta.	Oxygen	155-161	interleukin-1 beta	Oryctolagus cuniculus	184-192
25288742-5	2014	Here we show that peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) is highly expressed in the intestinal epithelium and possesses dual activity, stimulating mitochondrial biogenesis and oxygen consumption while inducing antioxidant enzymes.	Oxygen	216-222	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	18-84
25288742-5	2014	Here we show that peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) is highly expressed in the intestinal epithelium and possesses dual activity, stimulating mitochondrial biogenesis and oxygen consumption while inducing antioxidant enzymes.	Oxygen	216-222	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	86-95
25294927-3	2014	Using live cell imaging, we demonstrate the parkin-dependent recruitment of optineurin to mitochondria damaged by depolarization or reactive oxygen species.	Oxygen	141-147	optineurin	Homo sapiens	76-86
25061917-8	2014	TD-1 increased the oxygen affinity of sickle hemoglobin and inhibited in vitro hypoxia-induced sickling of red blood cells in patients with sickle cell disease without causing hemolysis.	Oxygen	19-25	TLX1 neighbor	Homo sapiens	0-4
25310726-2	2014	The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation.	Oxygen	55-61	similar	Drosophila melanogaster	116-140
25319447-8	2014	It was also observed that the expression levels of p53 and the phospho-p53 were enhanced in the presence of additive oxygen flow compared with those from the pure helium plasma treatment.	Oxygen	117-123	tumor protein p53	Homo sapiens	51-54
25319447-8	2014	It was also observed that the expression levels of p53 and the phospho-p53 were enhanced in the presence of additive oxygen flow compared with those from the pure helium plasma treatment.	Oxygen	117-123	tumor protein p53	Homo sapiens	71-74
25358785-0	2014	Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.	Oxygen	118-120	mitogen-activated protein kinase 14	Homo sapiens	14-17
25358785-0	2014	Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.	Oxygen	118-120	NFE2 like bZIP transcription factor 2	Homo sapiens	28-33
25358785-5	2014	Under 21% O2, increased p38 phosphorylation led to activation of p21.	Oxygen	10-12	mitogen-activated protein kinase 14	Homo sapiens	24-27
25358785-7	2014	The upregulation of NRF-2 antioxidant defense genes under 21% O2 may interact with cell-cycle-related proteins involved in regulating cell proliferation.	Oxygen	62-64	NFE2 like bZIP transcription factor 2	Homo sapiens	20-25
25358785-8	2014	Activation of p38/p21/NRF-2 in hDPSCs cultured under ambient oxygen tension inhibits stem cell proliferation and upregulates NRF-2 antioxidant defenses.	Oxygen	61-67	mitogen-activated protein kinase 14	Homo sapiens	14-17
25358785-8	2014	Activation of p38/p21/NRF-2 in hDPSCs cultured under ambient oxygen tension inhibits stem cell proliferation and upregulates NRF-2 antioxidant defenses.	Oxygen	61-67	NFE2 like bZIP transcription factor 2	Homo sapiens	22-27
25358785-8	2014	Activation of p38/p21/NRF-2 in hDPSCs cultured under ambient oxygen tension inhibits stem cell proliferation and upregulates NRF-2 antioxidant defenses.	Oxygen	61-67	NFE2 like bZIP transcription factor 2	Homo sapiens	125-130
25329456-0	2014	Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.	Oxygen	117-123	thioredoxin interacting protein	Mus musculus	12-43
25329456-0	2014	Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.	Oxygen	117-123	thioredoxin interacting protein	Mus musculus	45-50
25085889-5	2014	When breathing 40% O2, which minimizes contributions from diffusion limitation and alveolar ventilation-to-perfusion inequality, the A-aDO2 increased by 12 +- 7 mmHg during 320 ADR, and by 9 +- 6 mmHg during ATR + 80 ADR, and the change in calculated Q VA /QT was +2% in both conditions.	Oxygen	19-21	ATR serine/threonine kinase	Homo sapiens	208-211
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	regulator of cell cycle	Sus scrofa	31-35
25301052-4	2014	Mechanistically, we discover that Lin28A and Lin28B enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1, in a hypoxia- or hypoxia-inducible factor-1 (HIF-1)-independent manner, illustrating a novel pathway to mediate aerobic glycolysis of cancer cells even in ambient oxygen levels.	Oxygen	325-331	lin-28 homolog A	Homo sapiens	34-40
25301052-4	2014	Mechanistically, we discover that Lin28A and Lin28B enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1, in a hypoxia- or hypoxia-inducible factor-1 (HIF-1)-independent manner, illustrating a novel pathway to mediate aerobic glycolysis of cancer cells even in ambient oxygen levels.	Oxygen	325-331	lin-28 homolog B	Homo sapiens	45-51
25301052-4	2014	Mechanistically, we discover that Lin28A and Lin28B enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1, in a hypoxia- or hypoxia-inducible factor-1 (HIF-1)-independent manner, illustrating a novel pathway to mediate aerobic glycolysis of cancer cells even in ambient oxygen levels.	Oxygen	325-331	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-205
25210805-8	2014	On the basis of the comparison with other HAT Pb(II) and Bi(III) systems, the "volume" of this lone pair correlates well with the bond distance distributions and the number of the proximal oxygen atoms tethered to the post-transition metal cation.	Oxygen	189-195	submaxillary gland androgen regulated protein 3B	Homo sapiens	46-52
24954800-5	2014	In the last ten years, our group has demonstrated the generation of singlet molecular oxygen from reactions involving the decomposition of biologically relevant hydroperoxides, especially from lipid hydroperoxides in the presence of metal ions, peroxynitrite, HOCl and cytochrome c.	Oxygen	86-92	cytochrome c, somatic	Homo sapiens	269-281
25080497-0	2014	Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.	Oxygen	4-6	insulin	Homo sapiens	129-136
25080497-3	2014	Both C-peptide and insulin individually inhibit low O2-induced ATP release from healthy human erythrocytes, yet when coadministered at physiological concentrations and ratios, no inhibition is seen.	Oxygen	52-54	insulin	Homo sapiens	19-26
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	endothelial PAS domain protein 1	Sus scrofa	63-68
25299781-0	2014	Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.	Oxygen	57-63	BCL2 modifying factor	Mus musculus	115-118
25299781-1	2014	Stress signaling in response to oxygen/glucose deprivation (OGD) and ischemic injury activates a group of pro-apoptotic genes, the Bcl-2 homology domain 3 (BH3)-only proteins, which are capable of activating the mitochondrial apoptosis pathway.	Oxygen	32-38	B cell leukemia/lymphoma 2	Mus musculus	131-136
25050483-5	2014	C5aR expression levels in non-treated or 100% oxygen-treated mice were assessed by reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry.	Oxygen	46-52	complement component 5a receptor 1	Mus musculus	0-4
25106938-6	2014	Blastocysts in reduced oxygen (5 %) had low levels of both SA-beta-gal and gamma-H2A.X compared with blastocysts cultured in ambient oxygen.	Oxygen	23-29	H2A.X variant histone	Mus musculus	75-86
25016313-0	2014	Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS.	Oxygen	14-20	nitric oxide synthase 2	Homo sapiens	54-58
25371520-13	2014	This free radical of GSSG can then donate an electron to the oxygen molecule, producing O2 ( -) Subsequently, O2 ( -) is eliminated by SOD.	Oxygen	61-67	superoxide dismutase 1	Homo sapiens	135-138
25371520-13	2014	This free radical of GSSG can then donate an electron to the oxygen molecule, producing O2 ( -) Subsequently, O2 ( -) is eliminated by SOD.	Oxygen	88-90	superoxide dismutase 1	Homo sapiens	135-138
25371520-13	2014	This free radical of GSSG can then donate an electron to the oxygen molecule, producing O2 ( -) Subsequently, O2 ( -) is eliminated by SOD.	Oxygen	110-112	superoxide dismutase 1	Homo sapiens	135-138
25091694-1	2014	Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
25705415-0	2014	Thrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats.	Oxygen	69-75	thrombomodulin	Rattus norvegicus	0-14
25705415-6	2014	Rats ventilated with a tidal volume of 6 ml/kg under 100% oxygen with rhsTM (LV (low tidal volume)/TM) or saline (LV/SAL) were used as controls.	Oxygen	58-64	thrombomodulin	Rattus norvegicus	73-75
25091694-1	2014	Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
25302049-2	2014	Several single nucleotide polymorphisms (SNPs) of HIF-1alpha gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1alpha activity.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
25241037-4	2014	Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1alpha) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.	Oxygen	234-240	PPARG coactivator 1 alpha	Homo sapiens	56-125
25241037-4	2014	Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1alpha) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.	Oxygen	234-240	PPARG coactivator 1 alpha	Homo sapiens	127-135
25241037-4	2014	Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1alpha) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.	Oxygen	234-240	PPARG coactivator 1 alpha	Homo sapiens	151-161
24810896-5	2014	In the present paper, we analysed the role of SUS1 and SUS4, both induced by low oxygen, in plant survival and ethanol production.	Oxygen	81-87	sucrose synthase 1	Arabidopsis thaliana	46-50
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	38-44	interleukin 1 beta	Homo sapiens	184-192
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	38-44	tumor necrosis factor	Homo sapiens	197-206
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	54-56	interleukin 1 beta	Homo sapiens	184-192
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	54-56	tumor necrosis factor	Homo sapiens	197-206
25751962-5	2014	If antioxidant structures with active ingredients of traditional Chinese medicines were introduced to improve the antioxidant activity of NSAIDs, they could scavenge the active oxygen species to protect the normal function of vascular endothelia and enhance the bioavailability of NO, which is conducive to enhance the cardiovascular safety of cyclooxygenase (COX-2) inhibitor.	Oxygen	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	360-365
24502504-6	2014	Also, pHBA-induced NO and H2 O2 could be compromised in NO synthesis mutants noa1, nia1 and nia2, or H2 O2 metabolism mutant rbohD/F, but suppressing NO accumulation with a NO synthesis inhibitor or using NO synthesis-related mutants did not reduce pHBA-induced H2 O2 accumulation.	Oxygen	29-31	nitrate reductase 1	Arabidopsis thaliana	83-87
24712343-7	2014	A low oxygen tension reduced lubricin gene expression levels in bovine superficial chondrocytes, TGF-beta1-treated middle/deep zone chondrocytes, and TGF-beta1-treated ATDC5 cells.	Oxygen	6-12	proteoglycan 4	Bos taurus	29-37
25302049-2	2014	Several single nucleotide polymorphisms (SNPs) of HIF-1alpha gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1alpha activity.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
25255025-1	2014	Hypoxia inducible factor 1alpha (HIF1alpha) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen.	Oxygen	176-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
25128463-3	2014	This study demonstrated that cocaine- and amphetamine-regulated transcript (CART) peptide, specifically CART55-102, increased the survival rate, but decreased the mortality of neurons exposed to oxygen-glucose deprivation (OGD), in a dose-dependent manner.	Oxygen	195-201	CART prepropeptide	Homo sapiens	29-74
25128463-3	2014	This study demonstrated that cocaine- and amphetamine-regulated transcript (CART) peptide, specifically CART55-102, increased the survival rate, but decreased the mortality of neurons exposed to oxygen-glucose deprivation (OGD), in a dose-dependent manner.	Oxygen	195-201	CART prepropeptide	Homo sapiens	76-80
25255025-1	2014	Hypoxia inducible factor 1alpha (HIF1alpha) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen.	Oxygen	176-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
25279352-13	2014	A concurrent enhancement of tumor oxygenation might improve results by decreasing HIF-1 activity while increasing the interaction of ascorbic acid with oxygen.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
25249606-0	2014	Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.	Oxygen	20-26	a disintegrin and metallopeptidase domain 15 (metargidin)	Mus musculus	120-126
25249606-2	2014	We have previously described that mice lacking the membrane-anchored metalloproteinase ADAM15 (a Disintegrin and Metalloprotease 15) have decreased pathological neovascularization of the retina in the oxygen-induced retinopathy (OIR) model.	Oxygen	201-207	a disintegrin and metallopeptidase domain 15 (metargidin)	Mus musculus	87-93
25201986-3	2014	The production of NO by granuloma macrophages expressing nitric oxide synthase-2 (NOS2) via l-arginine and oxygen is a key protective mechanism against mycobacteria.	Oxygen	107-113	nitric oxide synthase 2, inducible	Mus musculus	82-86
25226504-11	2014	Specifically, NRF2 knockdown resulted in enhanced cell death and increased singlet oxygen and ROS levels following PDT through the diminished expression of BCRP.	Oxygen	83-89	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
25166909-5	2014	These structures are in accord with oxygen-atom-transfer reactivity for pmARC-1 and persulfide bond cleavage chemistry for HMCS-CT.	Oxygen	36-42	MKKS centrosomal shuttling protein	Homo sapiens	123-127
24673633-4	2014	This was associated with significantly increased mRNA expression for antioxidant genes mediated by nuclear factor erythroid 2-related factor (Nrf2) in the O2 (n = 4) versus RA group (n = 5).	Oxygen	155-157	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-140
24878247-9	2014	Five percent O2 significantly increased the level of activated Notch1 and expression of its downstream gene, HES1.	Oxygen	13-15	notch receptor 1	Homo sapiens	63-69
25118587-4	2014	Upon the sandwich hybridization of DNA1-aptamer-DNA2, the signal probe could be captured on the aptasensor to catalyze the reduction of dissolved oxygen, the coreactant for cathodic ECL emission of QDs, leading to a decrease of ECL intensity and thus the "off" state.	Oxygen	146-152	DNA replication helicase/nuclease 2	Homo sapiens	48-52
24968694-4	2014	The obvious biological proxy for inferring the impact of changing O2-levels on life is the evolutionary history of the enzyme allowing organisms to tap into the redox power of molecular oxygen, i.e. the bioenergetic O2 reductases, alias the cytochrome and quinol oxidases.	Oxygen	66-68	SEC14 like lipid binding 2	Homo sapiens	148-151
24968694-4	2014	The obvious biological proxy for inferring the impact of changing O2-levels on life is the evolutionary history of the enzyme allowing organisms to tap into the redox power of molecular oxygen, i.e. the bioenergetic O2 reductases, alias the cytochrome and quinol oxidases.	Oxygen	186-192	SEC14 like lipid binding 2	Homo sapiens	148-151
25017175-1	2014	Synergistic release of platinum anticancer drugs and O2 can be achieved in an H2O2-responsive nanocarrier incorporated with catalase.	Oxygen	53-55	catalase	Homo sapiens	124-132
25038418-4	2014	Mitochondrial dysfunction may cause reduction of O2 consumption and subsequently activate prolyl hydroxylase, which leads to decreased level of HIF-1alpha.	Oxygen	49-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
24673633-4	2014	This was associated with significantly increased mRNA expression for antioxidant genes mediated by nuclear factor erythroid 2-related factor (Nrf2) in the O2 (n = 4) versus RA group (n = 5).	Oxygen	155-157	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146
24673633-5	2014	SOD3, an Nrf2-independent antioxidant, was significantly reduced in the O2-exposed mice compared with RA.	Oxygen	72-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
24993130-10	2014	Furthermore, H2O2 levels are decreased following CH as a result of diminished dismutation of O2 ( -) and increased H2O2 catalysis through GPx-1, leading to augmented ASIC1-dependent SOCE.	Oxygen	15-17	glutathione peroxidase 1	Rattus norvegicus	138-143
24993130-10	2014	Furthermore, H2O2 levels are decreased following CH as a result of diminished dismutation of O2 ( -) and increased H2O2 catalysis through GPx-1, leading to augmented ASIC1-dependent SOCE.	Oxygen	15-17	acid sensing ion channel subunit 1	Rattus norvegicus	166-171
25070608-7	2014	Finally, under the same conditions and increasing the oxygen partial pressure to 0.1 MPa in the feed, the oxygen permeation reached 12 mL min(-1)  cm(-2).	Oxygen	106-112	CD59 molecule (CD59 blood group)	Homo sapiens	138-144
25312135-1	2014	OBJECTIVE: To investigate the effect of phorbol 12-myristate 13-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (FMLP) on oxygen consumption of differentiated and non-differentiated immune cell lines by retinoic acid and calcitriol treatment which might be useful in subsequent elicitation of immunological action during immunosuppressive states.	Oxygen	130-136	formyl peptide receptor 1	Homo sapiens	121-125
25312135-7	2014	Exposure of differentiated U937 cells to PMA and FMLP increased significantly (P&lt;0.05) in their oxygen consumption when compared with the control.	Oxygen	99-105	formyl peptide receptor 1	Homo sapiens	49-53
25070608-5	2014	This membrane exhibited a promising oxygen permeation value of 4.8 mL min(-1)  cm(-2) at 1000  C upon using Ar and air as the sweep and feed gases, respectively.	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	70-76
25070608-6	2014	Mimicking oxyfuel operating conditions by switching argon to pure CO2 as a sweep gas at 1000  C and air as feed enabled an oxygen flux value of 5.6 mL min(-1)  cm(-2) to be reached.	Oxygen	123-129	CD59 molecule (CD59 blood group)	Homo sapiens	151-157
25070608-7	2014	Finally, under the same conditions and increasing the oxygen partial pressure to 0.1 MPa in the feed, the oxygen permeation reached 12 mL min(-1)  cm(-2).	Oxygen	54-60	CD59 molecule (CD59 blood group)	Homo sapiens	138-144
25043839-1	2014	The transcription factor hypoxia inducible factors (HIF)-1 functions as a master regulator of oxygen homeostasis.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-58
25312135-8	2014	PMA calcitriol-treated cells resulted in 55% oxygen consumption more than the control while FMLP oxygen consumption increased 78% by comparison with the control.	Oxygen	97-103	formyl peptide receptor 1	Homo sapiens	92-96
24953559-6	2014	AMP-activated protein kinase knock down reduced erythropoietin mediated increase in cellular oxidative function including the increased oxygen consumption rate, fatty acid utilization and induction of key metabolic genes.	Oxygen	136-142	erythropoietin	Homo sapiens	48-62
24583949-1	2014	Cure of infections with Leishmania major is critically dependent on the ability of macrophages to induce the type 2 nitic oxide (NO) synthase (NOS2) that produces high levels of NO in the presence of ample oxygen.	Oxygen	206-212	nitric oxide synthase 2, inducible	Mus musculus	143-147
24953559-9	2014	Additionally, AMP-activated protein kinase is found to be involved in erythropoietin stimulated increase in oxygen consumption rate, fatty acid oxidation and mitochondrial gene expression.	Oxygen	108-114	erythropoietin	Homo sapiens	70-84
24583949-2	2014	Therefore, we analyzed the oxygen levels found in leishmanial skin lesions and their effect on the NOS2-dependent leishmanicidal activity of macrophages (MPhi).	Oxygen	27-33	nitric oxide synthase 2, inducible	Mus musculus	99-103
24583949-10	2014	Low oxygen levels found at leishmanial skin lesions impaired the NOS2-dependent leishmanicidal activity of MPhi.	Oxygen	4-10	nitric oxide synthase 2, inducible	Mus musculus	65-69
24906456-0	2014	Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.	Oxygen	97-103	mitogen-activated protein kinase 14	Homo sapiens	23-26
25317019-0	2014	Bilirubin activates transcription of HIF-1alpha in human proximal tubular cells cultured in the physiologic oxygen content.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
25317019-2	2014	Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
24906456-0	2014	Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.	Oxygen	97-103	epidermal growth factor receptor	Homo sapiens	18-22
24906456-0	2014	Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.	Oxygen	97-103	mitogen-activated protein kinase 8	Homo sapiens	27-30
24906456-3	2014	Because epidermal growth factor receptor (EGFR) signaling is also redox regulated and participates in oxygen sensing and vasoconstriction in other systems, we explored the role of the EGFR and its signaling cascade (p38 and c-Jun N-amino-terminal kinase (JNK)) in DA contraction.	Oxygen	102-108	epidermal growth factor receptor	Homo sapiens	42-46
24906456-7	2014	In DA rings, EGF caused contraction while the specific EGFR inhibitor (AG1478) and the tyrosine kinase inhibitors (genistein or tyrphostin A23) selectively attenuated oxygen-induced contraction (p &lt; 0.01).	Oxygen	167-173	epidermal growth factor receptor	Homo sapiens	55-59
24906456-9	2014	Anisomycin, an activator of EGFR"s downstream kinases, p38 and JNK, caused DA contraction; conversely, oxygen-induced DA contraction was blocked by inhibitors of p38 mitogen-activated protein kinases (MAPK) (SB203580) or JNK (JNK inhibitor II).	Oxygen	103-109	epidermal growth factor receptor	Homo sapiens	28-32
24906456-9	2014	Anisomycin, an activator of EGFR"s downstream kinases, p38 and JNK, caused DA contraction; conversely, oxygen-induced DA contraction was blocked by inhibitors of p38 mitogen-activated protein kinases (MAPK) (SB203580) or JNK (JNK inhibitor II).	Oxygen	103-109	mitogen-activated protein kinase 14	Homo sapiens	55-58
24906456-9	2014	Anisomycin, an activator of EGFR"s downstream kinases, p38 and JNK, caused DA contraction; conversely, oxygen-induced DA contraction was blocked by inhibitors of p38 mitogen-activated protein kinases (MAPK) (SB203580) or JNK (JNK inhibitor II).	Oxygen	103-109	mitogen-activated protein kinase 14	Homo sapiens	162-165
24906456-9	2014	Anisomycin, an activator of EGFR"s downstream kinases, p38 and JNK, caused DA contraction; conversely, oxygen-induced DA contraction was blocked by inhibitors of p38 mitogen-activated protein kinases (MAPK) (SB203580) or JNK (JNK inhibitor II).	Oxygen	103-109	mitogen-activated protein kinase 8	Homo sapiens	221-224
24906456-9	2014	Anisomycin, an activator of EGFR"s downstream kinases, p38 and JNK, caused DA contraction; conversely, oxygen-induced DA contraction was blocked by inhibitors of p38 mitogen-activated protein kinases (MAPK) (SB203580) or JNK (JNK inhibitor II).	Oxygen	103-109	mitogen-activated protein kinase 8	Homo sapiens	221-224
24906456-10	2014	O2-induced phosphorylation of EGFR occurred within 5 min of increasing pO2 and was inhibited by mitochondrial-targeted overexpression of catalase.	Oxygen	0-2	epidermal growth factor receptor	Homo sapiens	30-34
24906456-11	2014	AG1478 prevented the oxygen-induced p38 and JNK phosphorylation.	Oxygen	21-27	mitogen-activated protein kinase 14	Homo sapiens	36-39
24906456-11	2014	AG1478 prevented the oxygen-induced p38 and JNK phosphorylation.	Oxygen	21-27	mitogen-activated protein kinase 8	Homo sapiens	44-47
24906456-12	2014	In conclusion, O2-induced EGFR transactivation initiates p38/JNK-mediated increases in cytosolic calcium and contributes to DA contraction.	Oxygen	15-17	epidermal growth factor receptor	Homo sapiens	26-30
24906456-12	2014	In conclusion, O2-induced EGFR transactivation initiates p38/JNK-mediated increases in cytosolic calcium and contributes to DA contraction.	Oxygen	15-17	mitogen-activated protein kinase 14	Homo sapiens	57-60
24906456-12	2014	In conclusion, O2-induced EGFR transactivation initiates p38/JNK-mediated increases in cytosolic calcium and contributes to DA contraction.	Oxygen	15-17	mitogen-activated protein kinase 8	Homo sapiens	61-64
24906456-14	2014	KEY MESSAGES: Oxygen activates epidermal growth factor receptor (EGFR) in ductus arteriosus (DA) smooth muscle cells.	Oxygen	14-20	epidermal growth factor receptor	Homo sapiens	31-63
24906456-14	2014	KEY MESSAGES: Oxygen activates epidermal growth factor receptor (EGFR) in ductus arteriosus (DA) smooth muscle cells.	Oxygen	14-20	epidermal growth factor receptor	Homo sapiens	65-69
24906456-15	2014	EGFR inhibition selectively attenuates O2-induced DA constriction.	Oxygen	39-41	epidermal growth factor receptor	Homo sapiens	0-4
24906456-17	2014	p38 MAPK and JNK mediated EGFR"s effects on oxygen-induced DA contraction.	Oxygen	44-50	mitogen-activated protein kinase 14	Homo sapiens	0-3
24906456-17	2014	p38 MAPK and JNK mediated EGFR"s effects on oxygen-induced DA contraction.	Oxygen	44-50	mitogen-activated protein kinase 8	Homo sapiens	13-16
24906456-17	2014	p38 MAPK and JNK mediated EGFR"s effects on oxygen-induced DA contraction.	Oxygen	44-50	epidermal growth factor receptor	Homo sapiens	26-30
24957212-3	2014	Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxia-inducible factor-1 (HIF-1), have been shown to be critically involved in virtually all processes of wound healing and remodeling.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-117
24957212-3	2014	Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxia-inducible factor-1 (HIF-1), have been shown to be critically involved in virtually all processes of wound healing and remodeling.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-124
25002363-5	2014	A2B adenosine receptor stimulation decreased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and stress-activated protein kinase/Jun-amino-terminal kinase (SAPK/JNK) at all three O2 concentrations.	Oxygen	206-208	mitogen-activated protein kinase 1	Homo sapiens	64-110
25009285-3	2014	We further demonstrate that Bmi1 expression might be directly regulated by hypoxia-inducible factor-1a (HIF-1a) under low oxygen.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-102
25009285-3	2014	We further demonstrate that Bmi1 expression might be directly regulated by hypoxia-inducible factor-1a (HIF-1a) under low oxygen.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-110
25129147-5	2014	The PHD2 p.[Asp4Glu; Cys127Ser] variant exhibits a lower K(m) value for oxygen, suggesting that it promotes increased HIF degradation under hypoxic conditions.	Oxygen	72-78	egl-9 family hypoxia inducible factor 1	Homo sapiens	4-8
25002363-5	2014	A2B adenosine receptor stimulation decreased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and stress-activated protein kinase/Jun-amino-terminal kinase (SAPK/JNK) at all three O2 concentrations.	Oxygen	206-208	mitogen-activated protein kinase 3	Homo sapiens	112-118
25002363-7	2014	Adenosine receptor A2B stimulation decreased VEGF expression at 2% and 8% O2 but led to increased levels at 21% O2.	Oxygen	74-76	vascular endothelial growth factor A	Homo sapiens	45-49
24924401-0	2014	Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.	Oxygen	80-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	8-12
24924401-5	2014	Immunohistochemistry revealed that Nrf2(-/-) mice with an intrahepatic shunt manifest changes to hepatic oxygen and protein expression gradients when compared with wild-type (WT) and non-shunted Nrf2(-/-) mice.	Oxygen	105-111	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
25128406-9	2014	However inhibition of VEGF-A with blocking antibodies (bevacizumab or anti-VEGF-A165b) had marked cytotoxic effects under low oxygen conditions presumably through the blockade of autocrine survival pathways.	Oxygen	126-132	vascular endothelial growth factor A	Homo sapiens	22-28
25124892-3	2014	Comparisons with three-dimensional (3-D) simulations and another PVI screening tool, BioVapor, show that the AAMB is suitable for application in a scenario involving a building with an impermeable foundation surrounded by open ground surface, where the atmosphere is regarded as the primary oxygen source.	Oxygen	291-297	methyltransferase like 7A	Homo sapiens	109-113
27774472-3	2014	Due to the obligatory requirement of molecular O2 as a co-substrate, the activity of PHDs is inhibited under hypoxic conditions, resulting in stabilized HIFalpha, which dimerizes with HIFbeta and, together with transcriptional co-activators CBP/p300, activates the transcription of its target genes.	Oxygen	47-49	CREB binding protein	Homo sapiens	241-249
27774472-5	2014	The HIF1alpha isoform in particular has a strong impact on cellular metabolism, most notably by promoting anaerobic, whilst inhibiting O2-dependent, metabolism of glucose.	Oxygen	135-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-13
25116264-1	2014	A detailed chemical kinetic model for oxidation of CS2 has been developed, on the basis of ab initio calculations for key reactions, including CS2 + O2 and CS + O2, and data from literature.	Oxygen	149-151	chorionic somatomammotropin hormone 2	Homo sapiens	51-54
25116264-1	2014	A detailed chemical kinetic model for oxidation of CS2 has been developed, on the basis of ab initio calculations for key reactions, including CS2 + O2 and CS + O2, and data from literature.	Oxygen	149-151	chorionic somatomammotropin hormone 2	Homo sapiens	143-146
24983538-5	2014	The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2.	Oxygen	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
24657643-2	2014	The prepared sensor exhibits a remarkable sensitivity of (16.18muA/muM) with a linear range of 5.0x10(-11)-5.0x10(-6)M and limit of detection as low as 1.0x10(-11)M in the detection of DA, which might be due to the plenty cavities for binding DA through pi-pi stacking between aromatic rings and hydrogen bonds between amino groups of DA and oxygen-containing groups of the novel PPy.	Oxygen	342-348	latexin	Homo sapiens	67-70
24894671-1	2014	Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis.	Oxygen	183-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-97
24894671-1	2014	Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis.	Oxygen	183-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
25165860-6	2014	Binding studies revealed that 3,6-DHF had a strong binding affinity to JNK1 (1.996 x 105 M-1) and that the 6-OH and the carbonyl oxygen of the C ring of 3,6-DHF participated in hydrogen bonding interactions with the carbonyl oxygen and the amide proton of Met111, respectively.	Oxygen	225-231	mitogen-activated protein kinase 8	Homo sapiens	71-75
25090036-5	2014	The (17)O hyperfine coupling constants determined for O2 in the SAP and TSAP isomers are similar to each other and to the values reported for several Gd(III) complexes comprising fast-exchanging ligands.	Oxygen	54-56	SH2 domain containing 1A	Homo sapiens	64-67
25128406-11	2014	In contrast in high oxygen conditions exogenous VEGF-A isoforms have a greater effect on trophoblast survival.	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	48-54
25071185-1	2014	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to oxygen deprivation.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24734982-5	2014	Maintenance of mouse PSCs in low oxygen was associated with a significant increase in the expression of early differentiation markers FGF5 and Eomes, while conversely we observed decreased expression of these genes in human PSCs.	Oxygen	33-39	fibroblast growth factor 5	Mus musculus	134-138
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	brachyury, T-box transcription factor T	Mus musculus	186-195
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	forkhead box A2	Mus musculus	209-214
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	brachyury, T-box transcription factor T	Mus musculus	242-251
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	forkhead box A2	Mus musculus	267-272
25071185-1	2014	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to oxygen deprivation.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
25088159-8	2014	There was a significant increase in expression of nestin mRNA and protein in human MSCs in response to hypoxia (1% O2) or the chemical hypoxia mimetic desferroxamine.	Oxygen	115-117	nestin	Homo sapiens	50-56
25133093-3	2014	At the same time, when the ionizing radiation energy is absorbed, these agents partially neutralize the "oxygen effect" as a radiobiological phenomenon, especially in the radiolysis of DNA; 2) Radiation protective agents that exert their effect at the system level by accelerating the post-radiation recovery of radiosensitive tissues through activation of a number of pro-inflammatory signaling pathways and an increase in the secretion of hematopoietic growth factors, including their use as mitigators in the early period after irradiation prior to the clinical development of acute radiation syndrome (ARS).	Oxygen	105-111	DNA replication helicase/nuclease 2	Homo sapiens	185-191
25019986-6	2014	In vivo, PDE4B deletion could attenuate the lung water content, histological signs of pulmonary injury and elevate the ratio of partial pressure of arterial O2 to fraction of inspired O2 (PaO2/FIO2 ratio).	Oxygen	157-159	phosphodiesterase 4B	Homo sapiens	9-14
25019986-6	2014	In vivo, PDE4B deletion could attenuate the lung water content, histological signs of pulmonary injury and elevate the ratio of partial pressure of arterial O2 to fraction of inspired O2 (PaO2/FIO2 ratio).	Oxygen	184-186	phosphodiesterase 4B	Homo sapiens	9-14
25099217-9	2014	The ASD subjects with lower ET-1 level demonstrated longer time of exercise and higher peak oxygen consumption (p &lt; 0.05).	Oxygen	92-98	endothelin 1	Homo sapiens	28-32
25125975-10	2014	Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes.	Oxygen	194-200	C-C motif chemokine ligand 11	Homo sapiens	82-89
25125975-10	2014	Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes.	Oxygen	194-200	interleukin 6	Homo sapiens	91-95
24726894-1	2014	Hypoxia-inducible transcription factor-1 (HIF-1) plays a decisive role in cell survival and adaptation to hypoxic stress by controlling the expression of genes involved in oxygen homeostasis.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-40
25089613-8	2014	Under hypoxia, downregulation of HIF-1alpha and upregulation of caspase-3, caspase-8, caspase-9, LC3 and Beclin-1 were observed when paclitaxel was combined with oxygen-CNT.	Oxygen	162-168	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
24769115-2	2014	When the DFO was added to human umbilical vein endothelial cells cultured in 5.0% O2, the level of hypoxia-inducible factor-1alpha and vascular endothelial growth factor significantly increased compared with that without DFO.	Oxygen	82-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-130
24726894-1	2014	Hypoxia-inducible transcription factor-1 (HIF-1) plays a decisive role in cell survival and adaptation to hypoxic stress by controlling the expression of genes involved in oxygen homeostasis.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
24914935-6	2014	The addition of GDP and BSA to inhibit uncoupling protein 1 decreased oxygen consumption in BAT mitochondria equally in both groups.	Oxygen	70-76	uncoupling protein 1	Rattus norvegicus	39-59
24374745-9	2014	Mechanistic investigations suggested that HIF-1alpha degradation during hypoxia could be attributed to reduced mitochondrial O2 consumption in Nrf2-inhibited cells.	Oxygen	125-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
24743965-8	2014	In pre-capillary pulmonary hypertension, oxygen uptake was also lower at the anaerobic threshold (41 +- 11% versus 50 +- 8% predicted, p=0.04) and at peak exercise (12.8 +- 1.6 versus 15.0 +- 2.5 mL   kg(-1)   min(-1), p=0.02).	Oxygen	41-47	CD59 molecule (CD59 blood group)	Homo sapiens	210-216
24374745-9	2014	Mechanistic investigations suggested that HIF-1alpha degradation during hypoxia could be attributed to reduced mitochondrial O2 consumption in Nrf2-inhibited cells.	Oxygen	125-127	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
24721989-5	2014	RESULTS: The average peak values for all of the drivers with respect to oxygen uptake and heart rate were 4.5+-0.8 L min-1 (56.7+-7.9 mL min-1 kg-1) and 193+-5 beats min-1, respectively.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	117-122
24716787-0	2014	Nrf2 activation in astrocytes contributes to spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning.	Oxygen	98-104	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
24716787-1	2014	In this study, we investigated whether nuclear factor erythroid 2-related factor 2 (Nrf2) activation in astrocytes contributes to the neuroprotection induced by a single hyperbaric oxygen preconditioning (HBO-PC) against spinal cord ischemia/reperfusion (SCIR) injury.	Oxygen	181-187	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-82
24716787-1	2014	In this study, we investigated whether nuclear factor erythroid 2-related factor 2 (Nrf2) activation in astrocytes contributes to the neuroprotection induced by a single hyperbaric oxygen preconditioning (HBO-PC) against spinal cord ischemia/reperfusion (SCIR) injury.	Oxygen	181-187	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
24722450-7	2014	Hypoxia-induced gene transcription is controlled by the transcription factors hypoxia-inducible transcription factor (HIF)-1alpha and HIF2alpha, which are constitutively produced but stable only under low oxygen conditions.	Oxygen	205-211	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-129
25935996-7	2014	The resultant UNG has demonstrated to show remarkable electrocatalytic activity toward oxygen reduction reaction (ORR) with better fuel selectivity, and stability than that of the commercially available 20 wt% Pt/C electrode using cyclic voltammetry (CV) and chronoamperometry.	Oxygen	87-93	uracil DNA glycosylase	Homo sapiens	14-17
24721989-5	2014	RESULTS: The average peak values for all of the drivers with respect to oxygen uptake and heart rate were 4.5+-0.8 L min-1 (56.7+-7.9 mL min-1 kg-1) and 193+-5 beats min-1, respectively.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	137-142
24721989-5	2014	RESULTS: The average peak values for all of the drivers with respect to oxygen uptake and heart rate were 4.5+-0.8 L min-1 (56.7+-7.9 mL min-1 kg-1) and 193+-5 beats min-1, respectively.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	137-142
24861242-7	2014	KEY RESULTS: Mechanically induced tissue damage, interference with the respiratory chain and oxygen (O2 ) deprivation increased nuclear HuC/D immunoreactivity.	Oxygen	93-99	ELAV like RNA binding protein 3	Mus musculus	136-139
24160851-4	2014	In gene expression analysis, low oxygen levels promoted HIF1A activation in a time-dependent manner, in both ALL cell lines.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-61
25199329-3	2014	Her Sp(O2) was 92-93% even after administration of 10 l x min(-1) oxygen through a reservoir-attached face mask.	Oxygen	66-72	CD59 molecule (CD59 blood group)	Homo sapiens	58-64
23359392-4	2014	Our previous studies have demonstrated that the chemopreventive bioflavonoid apigenin inhibited hypoxia-induced elevation of VEGF production at low oxygen conditions characteristic for solid tumors.	Oxygen	148-154	vascular endothelial growth factor A	Homo sapiens	125-129
23359392-5	2014	Low oxygen (hypoxia) and transforming growth factor-beta (TGF-beta) are two major factors responsible for increased VEGF secretion.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	116-120
24861242-7	2014	KEY RESULTS: Mechanically induced tissue damage, interference with the respiratory chain and oxygen (O2 ) deprivation increased nuclear HuC/D immunoreactivity.	Oxygen	101-103	ELAV like RNA binding protein 3	Mus musculus	136-139
24824450-3	2014	ARNT is also required by the hypoxia-inducible factor-1alpha (HIF-1alpha), a crucial regulator of responses to conditions of reduced oxygen.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-60
24882526-11	2014	Each neutral Co(II) porphyrin was also examined as to its catalytic activity for electroreduction of molecular oxygen when coated on an edge-plane pyrolytic graphite electrode in 1.0 M HClO4.	Oxygen	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
24780550-1	2014	Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a transcription factor that belongs to the PPAR family, but the role of PPAR-beta/delta in acute lung injury (ALI) induced by hyperbaric oxygen is unknown.	Oxygen	201-207	peroxisome proliferator-activated receptor delta	Rattus norvegicus	44-48
24780550-1	2014	Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a transcription factor that belongs to the PPAR family, but the role of PPAR-beta/delta in acute lung injury (ALI) induced by hyperbaric oxygen is unknown.	Oxygen	201-207	peroxisome proliferator-activated receptor delta	Rattus norvegicus	136-145
25080581-7	2014	Using an injury model of oxygen and glucose deprivation, we identified a similarly rapid bioenergetics response, yet with incomplete ATP recovery and decreased AMPK activity.	Oxygen	25-31	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	160-164
24824450-3	2014	ARNT is also required by the hypoxia-inducible factor-1alpha (HIF-1alpha), a crucial regulator of responses to conditions of reduced oxygen.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
24814023-0	2014	Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.	Oxygen	53-59	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	18-22
24814023-0	2014	Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.	Oxygen	53-59	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	156-167
25033834-4	2014	APE1/Ref-1 maintains cellular homeostasis (redox) via the activation of TFs that regulate various physiological processes and that crosstalk with redox balancing agents (for example, thioredoxin, catalase and superoxide dismutase) by controlling levels of reactive oxygen and nitrogen species.	Oxygen	265-271	catalase	Homo sapiens	196-229
25061885-3	2014	METHODOLOGY/PRINCIPAL FINDINGS: COX activities were measured via changes in oxygen consumption due to oxygenation of arachidonic acid (for COX-1) and arachidonic acid and 2-AG (for COX-2).	Oxygen	76-82	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	139-144
24979669-5	2014	Stoichiometric oxygen atom transfer from N2O to PPh3 was mediated by (IMes)Cu-FeCp(CO)2, indicating the presence of an N2O-activated intermediate that can be intercepted by exogenous reagents.	Oxygen	15-21	caveolin 1	Homo sapiens	48-52
25347858-7	2014	On day 12, gene expression analysis revealed that Nkx2.1 and Foxa2 (endodermal and early lung epithelial cell marker) were significantly upregulated at 5% oxygen tension in ESC and iPSC differentiated cultures compared to 20% oxygen conditions.	Oxygen	155-161	forkhead box A2	Mus musculus	61-66
25101250-8	2014	The concept of GRP as a mediator of ROS-induced tissue damage represents a paradigm shift about how O2 can cause injury, inflammation, and fibrosis.	Oxygen	100-102	gastrin releasing peptide	Mus musculus	15-18
25347858-7	2014	On day 12, gene expression analysis revealed that Nkx2.1 and Foxa2 (endodermal and early lung epithelial cell marker) were significantly upregulated at 5% oxygen tension in ESC and iPSC differentiated cultures compared to 20% oxygen conditions.	Oxygen	226-232	forkhead box A2	Mus musculus	61-66
25090517-6	2014	For the optically forbidden oxygen transition under investigation, a limit of detection (SNR = 1) of 810 ppm was achieved for a 10 ms acquisition time.	Oxygen	28-34	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	89-96
24780244-1	2014	Cytoglobin (Cygb) plays a role in regulating vasodilation in response to changes in local oxygen concentration by altering the rate of nitric oxide (NO) metabolism.	Oxygen	90-96	cytoglobin	Homo sapiens	0-10
24780244-1	2014	Cytoglobin (Cygb) plays a role in regulating vasodilation in response to changes in local oxygen concentration by altering the rate of nitric oxide (NO) metabolism.	Oxygen	90-96	cytoglobin	Homo sapiens	12-16
25010988-4	2014	Prolyl-4-hydroxylase 2 (PHD2) is known as an important mediator of the oxygen-dependent degradation of HIF-alpha subunits.	Oxygen	71-77	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-22
24705306-4	2014	Together, our findings suggest that Hif-1alpha and Hif-2alpha competitively bind to NICD and dynamically regulate the activation of Notch signaling in GSCs likely depending on different oxygen tensions, providing improved therapeutic opportunities for malignant gliomas.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
24901940-3	2014	The results of this long-term permeation operation revealed a stepwise increase in oxygen permeation values at 1000  C after each thermal cycle, reaching from 1.38 cm(3) (STP) min(-1) cm(-2) in the first cycle to 1.75 cm(3) (STP) min(-1) cm(-2) in the fourth cycle.	Oxygen	83-89	CD59 molecule (CD59 blood group)	Homo sapiens	176-182
24901940-3	2014	The results of this long-term permeation operation revealed a stepwise increase in oxygen permeation values at 1000  C after each thermal cycle, reaching from 1.38 cm(3) (STP) min(-1) cm(-2) in the first cycle to 1.75 cm(3) (STP) min(-1) cm(-2) in the fourth cycle.	Oxygen	83-89	CD59 molecule (CD59 blood group)	Homo sapiens	230-236
24901940-5	2014	Despite a partial decrease in oxygen permeation fluxes at 850  C, a steady state of 0.25 cm(3) (STP) min(-1) cm(-2) was reached and maintained for more than 100 h. The newly developed PSCF membrane also exhibited a higher oxygen permeation flux with He and CO2 sweeping at all measured temperatures compared to a similar La0.6Sr0.4Co0.8Fe0.2O3-delta (LSCF) membrane.	Oxygen	222-228	CD59 molecule (CD59 blood group)	Homo sapiens	101-107
25010988-4	2014	Prolyl-4-hydroxylase 2 (PHD2) is known as an important mediator of the oxygen-dependent degradation of HIF-alpha subunits.	Oxygen	71-77	egl-9 family hypoxia inducible factor 1	Homo sapiens	24-28
24988463-0	2014	The transcription factor MEF2C negatively controls angiogenic sprouting of endothelial cells depending on oxygen.	Oxygen	106-112	myocyte enhancer factor 2C	Mus musculus	25-30
24988463-9	2014	Taken together, this suggests that the MEF2C/alpha-2-macroglobulin axis functions in endothelial cells as a negative feed-back mechanism that adapts sprouting activity to the oxygen concentration thus diminishing inappropriate and excess angiogenesis.	Oxygen	175-181	alpha-2-macroglobulin	Mus musculus	45-66
24726658-10	2014	CONCLUSIONS: A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1alpha and HIF-2alpha-mediated and TSA-sensitive chromatin modification mechanisms.	Oxygen	63-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	186-196
24589481-10	2014	CONCLUSION: Disruption of NRG1-ErbB4 signaling in the parvalbumin-positive interneurons might, at least partially, contribute to the isoflurane-induced hippocampus-dependent cognitive impairment after exposure to isoflurane carried by 100% O2 in aged mice.	Oxygen	240-242	parvalbumin	Mus musculus	54-65
24726658-7	2014	RESULTS: Lowering O2 concentration from 21% to the physiologically relevant 5% level substantially affected cell characteristics, with induction of stemness-related-transcription-factor and stimulation of cell proliferative capacity, with increased colony-forming unit fibroblasts (CFU-F) centers exerting OCT4A, NANOG and HIF-1alpha and HIF-2alpha immunoreactivity.	Oxygen	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	323-333
24787051-4	2014	One potential oxygen responsive regulator of EVTs is the transforming growth factor-beta (TGFbeta) family of cytokines.	Oxygen	14-20	transforming growth factor beta 1	Homo sapiens	90-97
24787051-5	2014	This work aimed to determine the role of TGFbeta1, beta2 and beta3 in regulating EVT outgrowth in the low oxygen environment of early pregnancy.	Oxygen	106-112	transforming growth factor beta 1	Homo sapiens	41-49
24859482-1	2014	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24706325-0	2014	Circulating adiponectin levels are associated with peak oxygen uptake in Japanese.	Oxygen	56-62	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
24706325-1	2014	OBJECTIVE: The aim of this study was to investigate the link between circulating adiponectin levels and peak oxygen uptake and/or physical activity in Japanese.	Oxygen	109-115	adiponectin, C1Q and collagen domain containing	Homo sapiens	81-92
24706325-9	2014	CONCLUSION: Circulating adiponectin levels were associated with peak oxygen uptake rather than physical activity.	Oxygen	69-75	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35
24812122-3	2014	Overexpression of HIF-1alpha is detected in a wide spectrum of cancers via different kinds of mechanisms, including reduced oxygen concentration, loss-of-function of tumor suppressor gene, activating mutation of oncogenes, and hyperactivation of protein kinase signaling pathways.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
27774468-1	2014	The transcription of the erythropoietin (EPO) gene is tightly regulated by the hypoxia response pathway to maintain oxygen homeostasis.	Oxygen	116-122	erythropoietin	Homo sapiens	25-39
27774468-1	2014	The transcription of the erythropoietin (EPO) gene is tightly regulated by the hypoxia response pathway to maintain oxygen homeostasis.	Oxygen	116-122	erythropoietin	Homo sapiens	41-44
24840762-4	2014	RESULTS: Vasopressin therapy increased mean arterial pressure and decreased pulmonary/systemic pressure ratio, heart rate, and fraction of inspired oxygen.	Oxygen	148-154	arginine vasopressin	Homo sapiens	9-20
24859482-1	2014	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24916276-2	2014	The transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of HIF-1alpha, an oxygen-sensitive subunit of HIF-1, are mainly modulated by various post-translational modifications.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
24703970-6	2014	The ventilatory response to abrupt O2 inhalation was diminished in Hyperoxia rats at P4 and P6-7, consistent with smaller contributions of peripheral chemoreceptors to eupneic ventilation at these ages.	Oxygen	35-37	guanylate binding protein 2	Rattus norvegicus	92-96
24916276-2	2014	The transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of HIF-1alpha, an oxygen-sensitive subunit of HIF-1, are mainly modulated by various post-translational modifications.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-116
25109080-0	2014	The effect of hyperbaric oxygen therapy on ischemia-modified albumin levels in people with diabetes with foot ulcers.	Oxygen	25-31	albumin	Homo sapiens	61-68
24816917-2	2014	Hypoxic upregulation of Cygb as well as its altered expression in various human cancers suggest another possible role of this newly discovered globin in tumor cell response under low oxygen tension.	Oxygen	183-189	cytoglobin	Homo sapiens	24-28
24754893-8	2014	The results showed that simultaneous activation of beta2AR with a beta2AR agonist and inhibition of beta1AR with a selective beta1AR blocker normalized myocardial oxygen consumption, decreased myocardial damage, augmented cardiomyocyte survival, improved cardiac function, reduced the incidence of arrhythmia, thus decreasing the occurrence of cardiac events in perioperative aged rats undergoing non-cardiac surgery.	Oxygen	163-169	adrenoceptor beta 1	Rattus norvegicus	100-107
24754893-8	2014	The results showed that simultaneous activation of beta2AR with a beta2AR agonist and inhibition of beta1AR with a selective beta1AR blocker normalized myocardial oxygen consumption, decreased myocardial damage, augmented cardiomyocyte survival, improved cardiac function, reduced the incidence of arrhythmia, thus decreasing the occurrence of cardiac events in perioperative aged rats undergoing non-cardiac surgery.	Oxygen	163-169	adrenoceptor beta 1	Rattus norvegicus	125-132
25131089-0	2014	Islet oxygen consumption rate dose predicts insulin independence for first clinical islet allotransplants.	Oxygen	6-12	insulin	Homo sapiens	44-51
24967963-2	2014	Adaption to hypoxia is an essential cellular response that is controlled by the master oxygen-sensitive transcription factor HIF1 (hypoxia-inducible factor 1).	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-129
25112032-6	2014	At an applied voltage of 0.9 V, the biocathode MEC achieved a hydrogen production rate of 0.39 m3 m(-3) d(-1), with a current density of 134 Am(-3), chemical oxygen demand (COD) removal of 90%, a coulombic efficiency of 63%, a cathodic hydrogen recovery of 37%, and an energy efficiency based on an electricity input of 67%.	Oxygen	158-164	C-C motif chemokine ligand 28	Homo sapiens	47-50
25013382-3	2014	Dimethyloxaloylglycine (DMOG) can activate HIF-1alpha expression in cells at normal oxygen tension.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
24967963-2	2014	Adaption to hypoxia is an essential cellular response that is controlled by the master oxygen-sensitive transcription factor HIF1 (hypoxia-inducible factor 1).	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-157
24967811-7	2014	Oxygen sensing that is mediated through guanylate cyclases (gcy-31, 33, 35) is unlikely to be involved in conferring this sensitivity.	Oxygen	0-6	Guanylate cyclase;Soluble guanylate cyclase gcy-31	Caenorhabditis elegans	60-66
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	fibroblast growth factor 2	Homo sapiens	90-94
24796659-0	2014	Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
24796659-2	2014	Under such conditions, cells are believed to sense O2 changes primarily via hypoxia inducible factor 1 alpha (HIF1A).	Oxygen	51-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-108
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	vascular endothelial growth factor A	Homo sapiens	100-105
24796659-2	2014	Under such conditions, cells are believed to sense O2 changes primarily via hypoxia inducible factor 1 alpha (HIF1A).	Oxygen	51-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-115
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	mitogen-activated protein kinase kinase 7	Homo sapiens	204-207
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	77-79	fibroblast growth factor 2	Homo sapiens	90-94
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	77-79	vascular endothelial growth factor A	Homo sapiens	100-105
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	fibroblast growth factor 2	Homo sapiens	90-94
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	vascular endothelial growth factor A	Homo sapiens	100-105
24796659-4	2014	We recently reported that physiological chronic normoxia (PCN; 20-25 day, 3% O2) enhanced FGF2- and VEGFA-stimulated proliferation and migration of human umbilical vein endothelial cells (HUVECs) via the MEK/ERK1/2 and PI3K/AKT1 pathways compared to standard cell culture normoxia (SCN; ambient O2: ~21% O2).	Oxygen	295-297	mitogen-activated protein kinase kinase 7	Homo sapiens	204-207
24477458-6	2014	TG2/NF-kappaB-induced increase in HIF-1alpha expression was associated with increased glucose uptake, increased lactate production and decreased oxygen consumption by mitochondria.	Oxygen	145-151	transglutaminase 2	Homo sapiens	0-3
24987455-13	2014	An additional notable feature in both of these complexes are the bridging ability of the quin oxygen which forms a network of coordination bonds in between the four Pb(II) ions.	Oxygen	94-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	165-171
24949970-4	2014	Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal beta cell function.	Oxygen	100-106	C-type lectin domain family 16, member A	Mus musculus	52-59
24477458-6	2014	TG2/NF-kappaB-induced increase in HIF-1alpha expression was associated with increased glucose uptake, increased lactate production and decreased oxygen consumption by mitochondria.	Oxygen	145-151	nuclear factor kappa B subunit 1	Homo sapiens	4-13
24477458-6	2014	TG2/NF-kappaB-induced increase in HIF-1alpha expression was associated with increased glucose uptake, increased lactate production and decreased oxygen consumption by mitochondria.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
25375112-5	2014	RESULTS: Data suggests high intensity aerobic interval training increases peak oxygen consumption by a standardized mean difference of 3.60 mL/kg-1/min-1 (95% confidence interval, 0.28-4.91).	Oxygen	79-85	CD59 molecule (CD59 blood group)	Homo sapiens	143-153
24918289-1	2014	Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress.	Oxygen	90-96	erythropoietin	Homo sapiens	0-14
24918289-1	2014	Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress.	Oxygen	90-96	erythropoietin	Homo sapiens	16-19
24918289-3	2014	Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues.	Oxygen	231-237	erythropoietin	Homo sapiens	91-94
24906151-0	2014	Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity.	Oxygen	20-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
24906151-0	2014	Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity.	Oxygen	20-22	insulin	Homo sapiens	81-88
25016511-3	2014	Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcription factor and mediates various cellular responses to hypoxia, including metabolism, cell death and survival, angiogenesis, oxygen delivery, immune evasion, and genomic adaptation.	Oxygen	182-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24887070-6	2014	When chicks were incubated in low oxygen (hypoxia), miR-15a was significantly increased in embryonic lung tissue.	Oxygen	34-40	microRNA 15a	Gallus gallus	52-59
25016511-3	2014	Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcription factor and mediates various cellular responses to hypoxia, including metabolism, cell death and survival, angiogenesis, oxygen delivery, immune evasion, and genomic adaptation.	Oxygen	182-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24528233-4	2014	However, closer scrutiny of the same parameters in brain microvascular endothelial cells subjected to oxygen-glucose deprivation +- reperfusion revealed marked increases in prooxidant NADPH oxidase enzyme activity, superoxide anion release and in expressions of antioxidant enzyme catalase and tight junction protein claudin-5.	Oxygen	102-108	catalase	Homo sapiens	281-289
24879149-8	2014	Moreover, decreased GABARAPL1 expression led to cellular bioenergetic changes including increased basal oxygen consumption rate, increased intracellular ATP, increased total glutathione, and an accumulation of damaged mitochondria.	Oxygen	104-110	GABA type A receptor associated protein like 1	Homo sapiens	20-29
24668884-5	2014	Our findings provide a novel mechanism for HIF-1alpha regulation, in which oxygen-dependent HIF-1 activity is modulated by an oxygen-insensitive lipid metabolic enzyme.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
24668884-5	2014	Our findings provide a novel mechanism for HIF-1alpha regulation, in which oxygen-dependent HIF-1 activity is modulated by an oxygen-insensitive lipid metabolic enzyme.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
24668884-5	2014	Our findings provide a novel mechanism for HIF-1alpha regulation, in which oxygen-dependent HIF-1 activity is modulated by an oxygen-insensitive lipid metabolic enzyme.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
24668884-5	2014	Our findings provide a novel mechanism for HIF-1alpha regulation, in which oxygen-dependent HIF-1 activity is modulated by an oxygen-insensitive lipid metabolic enzyme.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
24627160-0	2014	Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.	Oxygen	0-6	TSC complex subunit 1	Homo sapiens	57-60
24696144-9	2014	Additionally, data suggest a dose-dependent increase in CLOCK gene expression with increased oxygen concentrations.	Oxygen	93-99	circadian locomotor output cycles kaput	Mus musculus	56-61
24704415-1	2014	Hypoxia is a recognized cause for solid tumors malignancy and resistance, probably via hypoxia-induced overexpression of the hypoxia-inducible factor (HIF)-1alpha, major modulator of the cell response to oxygen deprivation.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-162
24627160-0	2014	Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.	Oxygen	0-6	mechanistic target of rapamycin kinase	Homo sapiens	66-70
24627160-3	2014	This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells.	Oxygen	133-139	TSC complex subunit 1	Homo sapiens	33-36
24627160-3	2014	This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells.	Oxygen	133-139	TSC complex subunit 1	Homo sapiens	62-66
24002363-0	2014	Conversion rate of para-hydrogen to ortho-hydrogen by oxygen: implications for PHIP gas storage and utilization.	Oxygen	54-60	pleckstrin homology domain interacting protein	Homo sapiens	79-83
24696491-16	2014	This discovery implies that KAP1, RBP-Jkappa, and HIF-1alpha play an essential role in KSHV pathogenesis through subtle cross talk which is dependent on the oxygen levels in the infected cells.	Oxygen	157-163	tripartite motif containing 28	Homo sapiens	28-32
24696491-16	2014	This discovery implies that KAP1, RBP-Jkappa, and HIF-1alpha play an essential role in KSHV pathogenesis through subtle cross talk which is dependent on the oxygen levels in the infected cells.	Oxygen	157-163	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	34-44
24696491-16	2014	This discovery implies that KAP1, RBP-Jkappa, and HIF-1alpha play an essential role in KSHV pathogenesis through subtle cross talk which is dependent on the oxygen levels in the infected cells.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
24439479-5	2014	Additionally, among ApoE3+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was positively correlated with p-tau (r = 0.30, p = 0.023), t-tau (r = 0.31, p = 0.021), and Abeta-42 (r = 0.31, p = 0.021).	Oxygen	71-73	apolipoprotein E	Homo sapiens	20-25
25057524-5	2014	The expression levels of NRF2 and its downstream antioxidant genes were higher in 8-cell, 16-cell, and blastocyst stages under high oxygen tension, whereas KEAP1 expression was down-regulated under the same conditions.	Oxygen	132-138	NFE2 like bZIP transcription factor 2	Bos taurus	25-29
25057524-6	2014	Higher expression of NRF2 and lower ROS levels were detected in early (competent) blastocysts compared to their late (noncompetent) counterparts in both oxygen-tension groups.	Oxygen	153-159	NFE2 like bZIP transcription factor 2	Bos taurus	21-25
24439479-6	2014	In ApoE2+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was correlated with lower levels of CSF Abeta-42 (r = -0.71, p = 0.004), similarly to ApoE4+ subjects where there was also a trend toward lower CSF Abeta-42 levels.	Oxygen	54-56	apolipoprotein E	Homo sapiens	3-8
24439479-6	2014	In ApoE2+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was correlated with lower levels of CSF Abeta-42 (r = -0.71, p = 0.004), similarly to ApoE4+ subjects where there was also a trend toward lower CSF Abeta-42 levels.	Oxygen	54-56	apolipoprotein E	Homo sapiens	162-167
24972465-8	2014	Furthermore in obese subjects consumption of oxygen peak was inversely correlated with parameters of cardiometabolic risk, particularly insulin and HOMA index.	Oxygen	45-51	insulin	Homo sapiens	136-143
25003023-1	2014	Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen.	Oxygen	132-138	superoxide dismutase 1, soluble	Mus musculus	0-22
24722990-7	2014	Pharmacological inhibition or lentiviral knockdown of Nnt in N27 dopaminergic cells (a) decreased H2O2 catabolism, (b) decreased NADPH and increased NADP(+) levels, and (c) decreased basal, spare, and maximal mitochondrial oxygen consumption rates.	Oxygen	223-229	nicotinamide nucleotide transhydrogenase	Homo sapiens	54-57
24936444-5	2014	Pharmacological inhibition of NADPH oxidase, PKC-a, PKC-ss or PKC-ssI via their specific inhibitors and neutralisation of O2 ( -) by a cell-permeable superoxide dismutase mimetic, MnTBAP normalised all the aforementioned increases induced by hyperglycaemia.	Oxygen	122-124	protein kinase C alpha	Homo sapiens	45-48
25212028-4	2014	And HIF-1 alpha subunit decides the activity of HIF-1, which is regulated by oxygen.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-15
25212028-4	2014	And HIF-1 alpha subunit decides the activity of HIF-1, which is regulated by oxygen.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
24792722-5	2014	betaPix expression enhanced O2(-) production in resting cells and cells stimulated with EGF or phorbol ester.	Oxygen	28-30	Rho guanine nucleotide exchange factor 7	Homo sapiens	0-7
24792722-6	2014	betaPix(S340E) further enhanced O2(-) production, while betaPix(S340A) eliminated the betaPix effect.	Oxygen	32-34	Rho guanine nucleotide exchange factor 7	Homo sapiens	0-7
25003023-1	2014	Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen.	Oxygen	132-138	superoxide dismutase 1, soluble	Mus musculus	24-28
24835245-0	2014	The role of the HIF-1alpha transcription factor in increased cell division at physiological oxygen tensions.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
24755411-1	2014	Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC.	Oxygen	0-6	erythropoietin	Homo sapiens	35-49
24711448-0	2014	Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.	Oxygen	78-84	egl-9 family hypoxia inducible factor 1	Homo sapiens	18-22
24711448-2	2014	Tibetans bear a genetic signature in the prolyl hydroxylase domain protein 2 (PHD2/EGLN1) gene, which encodes for the central oxygen sensor of the hypoxia-inducible factor (HIF) pathway.	Oxygen	126-132	egl-9 family hypoxia inducible factor 1	Homo sapiens	78-82
24711448-2	2014	Tibetans bear a genetic signature in the prolyl hydroxylase domain protein 2 (PHD2/EGLN1) gene, which encodes for the central oxygen sensor of the hypoxia-inducible factor (HIF) pathway.	Oxygen	126-132	egl-9 family hypoxia inducible factor 1	Homo sapiens	83-88
24858344-10	2014	Importantly, this loss of mitochondrial function was accompanied by the inability of OVCA420 cells to cope with hypoxic stress, and a compromised ability to stabilize HIF-1alpha in response to 1% O2 hypoxia.	Oxygen	196-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-177
24630930-1	2014	Catalase is an antioxidant enzyme that catalyzes mainly the transformation of hydrogen peroxide into water and oxygen.	Oxygen	111-117	catalase	Homo sapiens	0-8
24835245-1	2014	HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1alpha.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
24835245-1	2014	HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1alpha.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
24835245-1	2014	HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1alpha.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
24835245-1	2014	HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1alpha.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
24835245-2	2014	HIF-1alpha has been carefully studied in the context of severe hypoxic stresses (&lt;1% O2), but it is also known to be present at oxygen tensions commonly found in normal tissues in vivo (~1-13% O2), albeit at much lower levels.	Oxygen	88-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
24835245-2	2014	HIF-1alpha has been carefully studied in the context of severe hypoxic stresses (&lt;1% O2), but it is also known to be present at oxygen tensions commonly found in normal tissues in vivo (~1-13% O2), albeit at much lower levels.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
24835245-2	2014	HIF-1alpha has been carefully studied in the context of severe hypoxic stresses (&lt;1% O2), but it is also known to be present at oxygen tensions commonly found in normal tissues in vivo (~1-13% O2), albeit at much lower levels.	Oxygen	196-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
24835245-4	2014	Here, we show that a transcriptionally active HIF-1alpha was up-regulated at 5% O2, both in normal and cancer cells, but only some of its target genes were elevated as a result.	Oxygen	80-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
24835245-5	2014	HIF-1alpha induction was in part dependent on the activation of the ERK1/2 MAPK signalling pathway, which we have previously shown is active at 5% O2.	Oxygen	147-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
24835245-5	2014	HIF-1alpha induction was in part dependent on the activation of the ERK1/2 MAPK signalling pathway, which we have previously shown is active at 5% O2.	Oxygen	147-149	mitogen-activated protein kinase 3	Homo sapiens	68-74
24835245-5	2014	HIF-1alpha induction was in part dependent on the activation of the ERK1/2 MAPK signalling pathway, which we have previously shown is active at 5% O2.	Oxygen	147-149	mitogen-activated protein kinase 3	Homo sapiens	75-79
24835245-7	2014	Moreover, absence of HIF-1alpha significantly reduced the growth advantage of cells cultured at 5% O2.	Oxygen	99-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
24835245-8	2014	In view of these data, we conclude that HIF-1alpha can be induced and activated at physiological oxygen tensions in a MAPK-dependent manner and that, although this does not lead to pro-survival responses to stress, it determines the increased cell proliferation rates that are common under these conditions.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
24835245-8	2014	In view of these data, we conclude that HIF-1alpha can be induced and activated at physiological oxygen tensions in a MAPK-dependent manner and that, although this does not lead to pro-survival responses to stress, it determines the increased cell proliferation rates that are common under these conditions.	Oxygen	97-103	mitogen-activated protein kinase 3	Homo sapiens	118-122
24716876-4	2014	The direct redox reaction of Cyt c, followed by the biochemical reaction between Cyt c and H2O2, established a reliable approach to determine H2O2 at an optimized potential with high selectivity over other reactive oxygen species (ROS), oxygen, metal ions, ascobic acid (AA), and so on.	Oxygen	215-221	cytochrome c, somatic	Homo sapiens	29-34
24716876-4	2014	The direct redox reaction of Cyt c, followed by the biochemical reaction between Cyt c and H2O2, established a reliable approach to determine H2O2 at an optimized potential with high selectivity over other reactive oxygen species (ROS), oxygen, metal ions, ascobic acid (AA), and so on.	Oxygen	215-221	cytochrome c, somatic	Homo sapiens	81-86
24800963-6	2014	The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen).	Oxygen	168-174	angiotensinogen	Homo sapiens	24-38
24800963-6	2014	The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen).	Oxygen	203-209	angiotensinogen	Homo sapiens	24-38
24806920-2	2014	The excess oxygen concentration within the plesiomorphic cyanobacterium Gloeobactor violaceus is only 0.025 muM, or four orders of magnitude lower than the oxygen concentration in air-saturated water.	Oxygen	11-17	latexin	Homo sapiens	108-111
24648344-0	2014	Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1alpha in breast cancer.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-100
24648344-2	2014	Hypoxia-inducible factor-1 (HIF1) has a pivotal role in the regulation of cellular responses to oxygen deficiency.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-32
24648344-4	2014	However, the molecular mechanism that controls oxygen-independent degradation of HIF1alpha has remained elusive.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-90
24806920-5	2014	Excess oxygen concentrations within individual cells of the apomorphic cyanobacteria Synechocystis and Synechococcus are 0.064 and 0.25 muM, respectively.	Oxygen	7-13	latexin	Homo sapiens	136-139
24648344-7	2014	We show that RHBDF1 interaction with the receptor of activated protein-C kinase-1 (RACK1) in breast cancer cells prevents RACK1-assisted, oxygen-independent HIF1alpha degradation.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-166
24806920-8	2014	Calculations show that the excess concentration within colonies that are ~40 mum or larger in diameter can be comparable to the oxygen concentration in air-saturated water, suggesting that species forming colonies require protection against reactive oxygen species even in the absence of oxygen in the surrounding atmosphere.	Oxygen	250-256	latexin	Homo sapiens	77-80
24668805-0	2014	Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface gamma-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP).	Oxygen	14-20	DNA damage inducible transcript 3	Homo sapiens	251-255
24788190-4	2014	Low oxygen resulted in upregulation of vascular endothelial growth factor and increased the proportion of tyrosine hydroxylase-immunoreactive (TH-ir) cells in both types of cultures (midbrain: 9.1 +- 0.5 and 17.1 +- 0.4 (P&lt;0.001); forebrain: 1.9 +- 0.4 and 3.9 +- 0.6 (P&lt;0.01) percent of total cells).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	39-73
24684437-8	2014	Meanwhile, HIF-1 expression also changed dynamically along with alteration in oxygen levels.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-16
24804159-3	2014	Hypoxia-inducible factor-1 (HIF-1), as the master regulator of oxygen homeostasis, is an important determinant of healing outcomes.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24804159-3	2014	Hypoxia-inducible factor-1 (HIF-1), as the master regulator of oxygen homeostasis, is an important determinant of healing outcomes.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24321330-3	2014	Increase in O &amp; G mass loading from 5 to 20 mg min(-1) caused decreases in both dissolved oxygen concentration and sediment redox potential, which affected treatment performance.	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	51-57
33412652-0	2014	Oxygen and Carbon Dioxide Solubility and Diffusivity in Solid Food Matrices: A Review of Past and Current Knowledge.	Oxygen	0-6	EH domain containing 1	Homo sapiens	89-93
24695395-10	2014	Blockage of galectin-3 activity by N-acetyllactosamine (LacNac 10 mmol/l) reduced both collagen I and O2(*-) production induced by leptin.	Oxygen	102-104	galectin 3	Rattus norvegicus	12-22
24626988-11	2014	By contrast, the transcriptional coactivator PGC-1alpha, which has roles in the regulation of mitochondrial biogenesis and reactive-oxygen-species detoxification, abrogated aSyn toxicity in both the axon and the cell body.	Oxygen	132-138	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Danio rerio	45-55
24390774-7	2014	Peak oxygen uptake was significantly and positively correlated with serum vaspin levels even after adjusting for age, physical activity evaluated by Sigma[metabolic equivalents x h per week (METs[Symbol: see text]h/w)], BMI, and other confounding factors in men.	Oxygen	5-11	serpin family A member 12	Homo sapiens	74-80
24733837-6	2014	The modification of HCN channel function is a photodynamic process that involves (1)O2, as supported by the dependence on dissolved oxygen in solutions, the inhibitory effect by a (1)O2 scavenger, and the results with the HCN2-SOG fusion protein.	Oxygen	81-86	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	222-226
24359187-5	2014	Hypoxia (1% O2 for 22 h) caused greater loss of viability and more marked activation of caspase 3/7 in the motor neuronal NSC-34 cell line stably transfected with the G93A mutant human SOD1 (G93A-NSC) than in the one with the wild-type SOD1 (WT-NSC) or in untransfected NSC-34.	Oxygen	12-14	superoxide dismutase 1	Homo sapiens	185-189
23397434-3	2014	This review focuses on the study of molecular complexes, design of which is inspired by the components of natural photosynthesis, and covers research from early triad reaction centers developed by the group of Gust, Moore, and Moore to recent photoelectrochemical systems capable of using light to convert water to oxygen and hydrogen.	Oxygen	315-321	GUST	Homo sapiens	210-214
24510616-6	2014	By immunochemical localization of astrocytes (GFAP), activated microglia (Cd11b), and total microglia (Iba-1), we identified an oxygen-sensing glial layer in the NTS, in which astrocytes are first activated after 1-6 hr of hypoxia, followed by microglia after 6-24 hr of hypoxia.	Oxygen	128-134	integrin alpha M	Mus musculus	74-79
24664207-8	2014	Under high light, CEF increased under photorespiratory conditions (high oxygen and low CO2), consistent with a primary role in energy balancing.	Oxygen	72-78	hypothetical protein	Arabidopsis thaliana	18-21
24685282-3	2014	However, the changes in P-gp and BCRP transporter expression coincide with those of oxygen tension in the placenta, and oxygen tension has been shown to modulate P-gp and BCRP expression in other tissues.	Oxygen	84-90	ATP binding cassette subfamily B member 1	Homo sapiens	24-28
24685282-3	2014	However, the changes in P-gp and BCRP transporter expression coincide with those of oxygen tension in the placenta, and oxygen tension has been shown to modulate P-gp and BCRP expression in other tissues.	Oxygen	84-90	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	33-37
24685282-3	2014	However, the changes in P-gp and BCRP transporter expression coincide with those of oxygen tension in the placenta, and oxygen tension has been shown to modulate P-gp and BCRP expression in other tissues.	Oxygen	120-126	ATP binding cassette subfamily B member 1	Homo sapiens	162-166
24685282-3	2014	However, the changes in P-gp and BCRP transporter expression coincide with those of oxygen tension in the placenta, and oxygen tension has been shown to modulate P-gp and BCRP expression in other tissues.	Oxygen	120-126	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	171-175
24685282-4	2014	The objective of this study was to investigate the effects of oxygen tension on P-gp and BCRP expression in the term human placenta.	Oxygen	62-68	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
24685282-4	2014	The objective of this study was to investigate the effects of oxygen tension on P-gp and BCRP expression in the term human placenta.	Oxygen	62-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	89-93
24685282-8	2014	RESULTS: Oxygen tension had a significant effect on P-gp expression, with ABCB1/P-gp mRNA and protein levels increased in the hypoxic condition (3% O2) after 48 h (p &lt; 0.05).	Oxygen	9-15	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
24685282-8	2014	RESULTS: Oxygen tension had a significant effect on P-gp expression, with ABCB1/P-gp mRNA and protein levels increased in the hypoxic condition (3% O2) after 48 h (p &lt; 0.05).	Oxygen	9-15	ATP binding cassette subfamily B member 1	Homo sapiens	74-79
24685282-8	2014	RESULTS: Oxygen tension had a significant effect on P-gp expression, with ABCB1/P-gp mRNA and protein levels increased in the hypoxic condition (3% O2) after 48 h (p &lt; 0.05).	Oxygen	9-15	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
24685282-8	2014	RESULTS: Oxygen tension had a significant effect on P-gp expression, with ABCB1/P-gp mRNA and protein levels increased in the hypoxic condition (3% O2) after 48 h (p &lt; 0.05).	Oxygen	148-150	ATP binding cassette subfamily B member 1	Homo sapiens	74-79
24685282-8	2014	RESULTS: Oxygen tension had a significant effect on P-gp expression, with ABCB1/P-gp mRNA and protein levels increased in the hypoxic condition (3% O2) after 48 h (p &lt; 0.05).	Oxygen	148-150	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
24685282-10	2014	In contrast, placental ABCG2/BCRP mRNA and protein expression were stable with changes in oxygen tension.	Oxygen	90-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	23-28
24685282-10	2014	In contrast, placental ABCG2/BCRP mRNA and protein expression were stable with changes in oxygen tension.	Oxygen	90-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	29-33
24685282-12	2014	CONCLUSIONS: These findings demonstrate that, at term, the expression of placental P-gp, is regulated by oxygen tension.	Oxygen	105-111	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
24642336-0	2014	CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.	Oxygen	52-58	CD34 molecule	Homo sapiens	0-4
24405386-0	2014	Human adipose-derived stromal/stem cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture conditions.	Oxygen	110-116	CD4 molecule	Homo sapiens	59-62
24405386-4	2014	Forkhead box P3 (FoxP3) and transforming growth factor beta (TGF-beta) mRNA expression were significantly increased when ASCs were cocultured with CD4(+) T cells under low compared with ambient O2 conditions.	Oxygen	194-196	transforming growth factor beta 1	Homo sapiens	28-59
24405386-4	2014	Forkhead box P3 (FoxP3) and transforming growth factor beta (TGF-beta) mRNA expression were significantly increased when ASCs were cocultured with CD4(+) T cells under low compared with ambient O2 conditions.	Oxygen	194-196	transforming growth factor beta 1	Homo sapiens	61-69
24405386-4	2014	Forkhead box P3 (FoxP3) and transforming growth factor beta (TGF-beta) mRNA expression were significantly increased when ASCs were cocultured with CD4(+) T cells under low compared with ambient O2 conditions.	Oxygen	194-196	CD4 molecule	Homo sapiens	147-150
24634066-4	2014	The ability of oxygen to generate S-thiolation artifacts was tested by comparing purification of SOD1 from postmortem human cerebral cortex under aerobic and anaerobic conditions.	Oxygen	15-21	superoxide dismutase 1	Homo sapiens	97-101
25669098-0	2014	[Erythropoietin influence on the blood oxygen transport and prooxidant-antioxidant state during hepatic ischemia-reperfusion].	Oxygen	39-45	erythropoietin	Homo sapiens	1-15
24642336-0	2014	CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.	Oxygen	74-80	CD34 molecule	Homo sapiens	0-4
24405386-5	2014	The low O2-induced regulatory T cells (iTregs) exhibited functionality when added to mixed lymphocyte reactions as demonstrated by inhibition of peripheral blood mononuclear cell proliferation, and by &gt;300-fold increase in FoxP3 mRNA, and &gt;2-fold increase in TGF-beta mRNA expression.	Oxygen	8-10	transforming growth factor beta 1	Homo sapiens	265-273
24884656-6	2014	VO2 peak was correlated with body mass index, C-reactive protein, FEV1, FVC, RV, DLCO, VE/VCO2 peak, VD/VT, PaO2, PaCO2, P(A-a)O2, and breathing reserve.	Oxygen	1-3	C-reactive protein	Homo sapiens	46-64
24405386-6	2014	These results demonstrate that under physiologically relevant low O2 conditions, direct contact of human ASCs with naive CD4(+) T cells induced functional iTregs.	Oxygen	66-68	CD4 molecule	Homo sapiens	121-124
24333723-5	2014	Among them, HIF-1alpha is known to be the master regulator of cellular oxygen homeostasis, mediating transcriptional activation of lymphangiogenesis via regulation of signaling cascades like VEGF-A/-C/-D, TGF-beta and Prox-1 in experimental and human tumors.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-110
24460692-7	2014	However, physical removal of dissolved oxygen prior to RF-PRT protects ADAMTS13 as well as FVIII and fibrinogen from damage, indicating a direct role for reactive oxygen species.	Oxygen	39-45	fibrinogen beta chain	Homo sapiens	101-111
25151725-1	2014	Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings.	Oxygen	180-186	aldehyde oxidase 1	Homo sapiens	0-16
25151725-1	2014	Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings.	Oxygen	180-186	aldehyde oxidase 1	Homo sapiens	18-21
24333723-5	2014	Among them, HIF-1alpha is known to be the master regulator of cellular oxygen homeostasis, mediating transcriptional activation of lymphangiogenesis via regulation of signaling cascades like VEGF-A/-C/-D, TGF-beta and Prox-1 in experimental and human tumors.	Oxygen	71-77	vascular endothelial growth factor A	Homo sapiens	191-197
24333723-5	2014	Among them, HIF-1alpha is known to be the master regulator of cellular oxygen homeostasis, mediating transcriptional activation of lymphangiogenesis via regulation of signaling cascades like VEGF-A/-C/-D, TGF-beta and Prox-1 in experimental and human tumors.	Oxygen	71-77	transforming growth factor beta 1	Homo sapiens	205-213
24291771-0	2014	Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice.	Oxygen	58-64	interleukin 10	Mus musculus	0-14
24291771-1	2014	The aim of present study was to elucidate the role of Interleukin-10 (IL-10) in the neuroprotection of hyperbaric oxygen (HBO) against traumatic brain injury (TBI) in mice.	Oxygen	114-120	interleukin 10	Mus musculus	54-68
24291771-1	2014	The aim of present study was to elucidate the role of Interleukin-10 (IL-10) in the neuroprotection of hyperbaric oxygen (HBO) against traumatic brain injury (TBI) in mice.	Oxygen	114-120	interleukin 10	Mus musculus	70-75
24610812-9	2014	An important effect of calmodulin binding is to suppress adventitious electron transfer from nNOS to molecular oxygen and thereby preventing accumulation of reactive oxygen species.	Oxygen	111-117	calmodulin 1	Homo sapiens	23-33
24755153-1	2014	BACKGROUND: Glutathionylation of endothelial nitric oxide synthase (eNOS) "uncouples" the enzyme, switching its function from nitric oxide (NO) to O2( -) generation.	Oxygen	147-149	nitric oxide synthase 3	Homo sapiens	33-66
24670063-1	2014	Dehaloperoxidase hemoglobin A (DHP A) is a multifunctional hemoglobin that appears to have evolved oxidative pathways for the degradation of xenobiotics as a protective function that complements the oxygen transport function.	Oxygen	199-205	dihydropyrimidinase	Homo sapiens	31-34
24755153-6	2014	Moreover, Ang II-induced increase in O2( -) and decrease in NO were abolished in HUVECs transiently transfected, with mutant eNOS rendered resistant to glutathionylation.	Oxygen	37-39	angiotensinogen	Homo sapiens	10-16
24755153-9	2014	Furthermore, attenuation of Ang II signaling in vivo by administration of an angiotensin converting enzyme (ACE) inhibitor reduced eNOS glutathionylation, increased NO, diminished O2( -), improved endothelium-dependent vasorelaxation and reduced blood pressure.	Oxygen	180-182	angiotensinogen	Homo sapiens	28-34
24755153-9	2014	Furthermore, attenuation of Ang II signaling in vivo by administration of an angiotensin converting enzyme (ACE) inhibitor reduced eNOS glutathionylation, increased NO, diminished O2( -), improved endothelium-dependent vasorelaxation and reduced blood pressure.	Oxygen	180-182	angiotensin I converting enzyme	Homo sapiens	77-106
24755153-9	2014	Furthermore, attenuation of Ang II signaling in vivo by administration of an angiotensin converting enzyme (ACE) inhibitor reduced eNOS glutathionylation, increased NO, diminished O2( -), improved endothelium-dependent vasorelaxation and reduced blood pressure.	Oxygen	180-182	angiotensin I converting enzyme	Homo sapiens	108-111
24755153-11	2014	We suggest that Ang II-induced O2( -) generation in endothelial cells, although dependent on NADPH oxidase, is amplified by glutathionylation-dependent eNOS uncoupling.	Oxygen	31-33	angiotensinogen	Homo sapiens	16-22
24503013-6	2014	Exposing hepatocytes to 1% O2 reduced the mRNA expression of carnitine palmitoyltransferase 1 (CPT-1), which catalyzes the rate-limiting step in the mitochondrial import of fatty acids for beta-oxidation.	Oxygen	27-29	carnitine palmitoyltransferase 1A	Homo sapiens	61-93
24503013-6	2014	Exposing hepatocytes to 1% O2 reduced the mRNA expression of carnitine palmitoyltransferase 1 (CPT-1), which catalyzes the rate-limiting step in the mitochondrial import of fatty acids for beta-oxidation.	Oxygen	27-29	carnitine palmitoyltransferase 1A	Homo sapiens	95-100
24503685-8	2014	There was significantly more COL2A1 gene expression in normoxic group than that in low O2 group (P &lt; 0.05).	Oxygen	87-89	collagen type II alpha 1 chain	Homo sapiens	29-35
24583185-4	2014	The insulin sensitive group showed reduced blood oxygen level dependent (BOLD) signal in response to food pictures following glucose ingestion in numerous corticolimbic brain regions, whereas the insulin resistant group did not.	Oxygen	49-55	insulin	Homo sapiens	4-11
24561043-4	2014	The addition of NVP-BEZ235 reverses the EMT-like morphologic changes, down-regulation of E-cadherin, and enhancement of cell migration induced by 1% O2 partially through interfering with the expression and transcriptional activity of Hif-1alpha via PI3K/mTOR pathway.	Oxygen	149-151	cadherin 1	Homo sapiens	89-99
24561043-4	2014	The addition of NVP-BEZ235 reverses the EMT-like morphologic changes, down-regulation of E-cadherin, and enhancement of cell migration induced by 1% O2 partially through interfering with the expression and transcriptional activity of Hif-1alpha via PI3K/mTOR pathway.	Oxygen	149-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	234-244
24561043-4	2014	The addition of NVP-BEZ235 reverses the EMT-like morphologic changes, down-regulation of E-cadherin, and enhancement of cell migration induced by 1% O2 partially through interfering with the expression and transcriptional activity of Hif-1alpha via PI3K/mTOR pathway.	Oxygen	149-151	mechanistic target of rapamycin kinase	Homo sapiens	254-258
24673361-3	2014	When exposed to O2, it transformed from an EPR inactive to an EPR active species indicative of oxidation of Co(I) to Co(II) with the formation of H2O2.	Oxygen	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24535440-8	2014	Exposure of endothelial cells to hypoxia (1% O2) increased TH mRNA.	Oxygen	45-47	tyrosine hydroxylase	Homo sapiens	59-61
24733551-1	2014	OBJECTIVES: The mechanisms by which low oxygen availability are associated with the development of insulin resistance remain obscure.	Oxygen	40-46	insulin	Homo sapiens	99-106
24722573-0	2014	Vasostatin inhibits VEGF-induced endothelial cell proliferation, tube formation and induces cell apoptosis under oxygen deprivation.	Oxygen	113-119	vascular endothelial growth factor A	Homo sapiens	20-24
24554704-0	2014	High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.	Oxygen	5-11	insulin	Homo sapiens	128-135
24722573-6	2014	We found that vasostatin could inhibit the cell viability of HUVEC and induce cell apoptosis through mitochondrial pathways via activation of caspase-3 under oxygen deprivation conditions.	Oxygen	158-164	caspase 3	Homo sapiens	142-151
24562186-0	2014	Outer Co(II) ions in Co-ZIF-67 reversibly adsorb oxygen from both gas phase and liquid water.	Oxygen	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24562186-1	2014	Outer Co(II) species in Co-ZIF-67 coordinate molecular oxygen both from the gas phase and liquid water, through an adsorption process (presumably yielding in both cases surface superoxo species), respectively weak and reversible (gas phase), and strong and irreversible (liquid); in the latter case desorption is however brought about by illumination with solar light comprising the UV component.	Oxygen	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24705372-5	2014	Moreover, only the oxidized Cyt c form was reduced by the generated O2(-) that significantly enhanced the fluorescence of the QDs" system, which was also demonstrated by fluorescence imaging in HeLa cells.	Oxygen	68-70	cytochrome c, somatic	Homo sapiens	28-33
24554704-5	2014	In this study, we tried to establish an effective method for the differentiation of induced pluripotent stem cells (iPSCs) into insulin-producing cells by culturing under high oxygen (O2) conditions.	Oxygen	176-182	insulin	Homo sapiens	128-135
24554704-5	2014	In this study, we tried to establish an effective method for the differentiation of induced pluripotent stem cells (iPSCs) into insulin-producing cells by culturing under high oxygen (O2) conditions.	Oxygen	184-186	insulin	Homo sapiens	128-135
24554704-6	2014	Treatment with a high O2 condition in the early stage of differentiation increased insulin-positive cells at the terminus of differentiation.	Oxygen	22-24	insulin	Homo sapiens	83-90
24554704-10	2014	Optimal stage-specific treatment with a high O2 condition resulted in a significant increase in insulin production in both mouse embryonic stem cells and human iPSCs and yielded populations containing up to 10% C-peptide-positive cells in human iPSCs.	Oxygen	45-47	insulin	Homo sapiens	96-103
24554704-11	2014	These results suggest that culturing in a high O2 condition at a specific stage is useful for the efficient generation of insulin-producing cells.	Oxygen	47-49	insulin	Homo sapiens	122-129
24526696-5	2014	EVCs differentiated in 5% O2 had an increased vascular endothelial cadherin expression with clusters of vascular endothelial cadherin+ cells surrounded by platelet-derived growth factor beta+ cells.	Oxygen	26-28	cadherin 5	Homo sapiens	46-75
28788592-1	2014	Oxidation of ferritic/martensitic steel P92 was investigated in pure oxygen and in pure steam at 600-800  C by thermogravimetric analysis (TGA), optical microscopy (OM), scanning electron microscopy (SEM), and X-ray diffraction (XRD).	Oxygen	69-75	advillin	Homo sapiens	40-43
24526696-5	2014	EVCs differentiated in 5% O2 had an increased vascular endothelial cadherin expression with clusters of vascular endothelial cadherin+ cells surrounded by platelet-derived growth factor beta+ cells.	Oxygen	26-28	cadherin 5	Homo sapiens	104-133
24464498-8	2014	A quantitative structure-activity relationship model was developed and validated, and the maximal partial charge for an oxygen atom was the descriptor predicted as being implicated in P-gp activation by the dihydroxylated xanthones.	Oxygen	120-126	ATP binding cassette subfamily B member 1	Homo sapiens	184-188
24526696-7	2014	EVCs differentiated in 5% O2 exhibited an increased expression of vascular endothelial cadherin and CD31 along with their localization to the membrane, enhanced lectin binding and acetylated low-density lipoprotein uptake, rapid cord-like structure formation, and increased expression of arterial endothelial cell markers.	Oxygen	26-28	cadherin 5	Homo sapiens	66-95
24134698-8	2014	Effects of cardiolipin on electron transfer kinetics of cytochrome c were determined by cytochrome c reduction in vitro and oxygen consumption using mitoplasts, frozen and fresh mitochondria.	Oxygen	124-130	cytochrome c, somatic	Homo sapiens	56-68
24206264-6	2014	We measured ATP synthesis-dependent, -independent and cytochrome c-limited maximal oxygen consumption rates (OCRs) and cell death of immortalized wild-type (WT) and Drp1 knockout (KO) mouse embryonic fibroblasts (MEFs) treated with ABT-737.	Oxygen	83-89	cytochrome c, somatic	Homo sapiens	54-66
24506070-4	2014	Preterm PMSCs had greater proliferative response to IGF-I, which was further enhanced by low-oxygen tension.	Oxygen	93-99	insulin like growth factor 1	Homo sapiens	52-57
24474703-4	2014	The loss of a key hydrogen bond between the oxygen atom of the furanyl ring of the agonist and Thr 574 in TLR8 suggested that the furan ring is dispensable.	Oxygen	44-50	toll like receptor 8	Homo sapiens	106-110
24506070-6	2014	Low-oxygen tension prolonged ERK1/2 and AKT phosphorylation with a slowed phosphorylation decay even in presence of IGF-I.	Oxygen	4-10	mitogen-activated protein kinase 3	Homo sapiens	29-35
24506070-6	2014	Low-oxygen tension prolonged ERK1/2 and AKT phosphorylation with a slowed phosphorylation decay even in presence of IGF-I.	Oxygen	4-10	AKT serine/threonine kinase 1	Homo sapiens	40-43
24491879-1	2014	Neuroglobin is a neuron-specific hexacoordinated globin capable of binding various ligands, including O2, NO, and CO, the biological function of which is still uncertain.	Oxygen	102-104	neuroglobin	Rattus norvegicus	0-11
24506070-6	2014	Low-oxygen tension prolonged ERK1/2 and AKT phosphorylation with a slowed phosphorylation decay even in presence of IGF-I.	Oxygen	4-10	insulin like growth factor 1	Homo sapiens	116-121
24506070-7	2014	Low-oxygen tension maintained higher levels of IGF-I receptor and insulin receptor substrate 1 that were otherwise decreased by exposure to IGF-I and induced a differential phosphorylation pattern on IGF-I receptorbeta and insulin receptor substrate 1.	Oxygen	4-10	insulin like growth factor 1	Homo sapiens	47-52
24506070-7	2014	Low-oxygen tension maintained higher levels of IGF-I receptor and insulin receptor substrate 1 that were otherwise decreased by exposure to IGF-I and induced a differential phosphorylation pattern on IGF-I receptorbeta and insulin receptor substrate 1.	Oxygen	4-10	insulin like growth factor 1	Homo sapiens	140-145
24506070-7	2014	Low-oxygen tension maintained higher levels of IGF-I receptor and insulin receptor substrate 1 that were otherwise decreased by exposure to IGF-I and induced a differential phosphorylation pattern on IGF-I receptorbeta and insulin receptor substrate 1.	Oxygen	4-10	insulin like growth factor 1	Homo sapiens	140-145
24506070-9	2014	These studies demonstrate that low-oxygen tension regulates the fate of PMSCs from early and late gestations in response to IGF-I, both independently and dependently, via specific signal transduction mechanisms.	Oxygen	35-41	insulin like growth factor 1	Homo sapiens	124-129
24509158-1	2014	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low-oxygen environment.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24509158-1	2014	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low-oxygen environment.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24509158-1	2014	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low-oxygen environment.	Oxygen	250-256	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24509158-1	2014	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low-oxygen environment.	Oxygen	250-256	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24510339-0	2014	A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression.	Oxygen	60-66	erythropoietin	Homo sapiens	77-91
24232699-9	2014	APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p=0.009 and p&lt;0.001, respectively; R(2)=0.148) and ApoB levels (p=0.001 and p=0.003, respectively; R(2)=0.104).	Oxygen	22-28	apolipoprotein B	Homo sapiens	165-169
24624894-0	2014	Protective role of peroxisome proliferator-activated receptor-beta/delta against pulmonary oxygen toxicity mediated through changes in NOS expression levels.	Oxygen	91-97	peroxisome proliferator-activated receptor delta	Rattus norvegicus	19-72
24624894-1	2014	Recent studies have demonstrated that peroxisome proliferator-activated receptor-beta/delta (PPAR-beta/delta) has a protective effect during lung injury induced by bleomycin and polymicrobial sepsis, but its function in pulmonary oxygen toxicity is unknown.	Oxygen	230-236	peroxisome proliferator-activated receptor delta	Rattus norvegicus	93-102
24624894-12	2014	Collectively, these data indicate that PPAR-beta/delta activation can protect against pulmonary oxygen toxicity in the lungs of rats through changes in the expression of NOS.	Oxygen	96-102	peroxisome proliferator-activated receptor delta	Rattus norvegicus	39-48
24201705-4	2014	Two of these loci, EGLN1 and EPAS1, encode major components of the hypoxia-inducible factor transcriptional system, which has a central role in oxygen sensing and coordinating an organism"s response to hypoxia, as evidenced by studies in humans and mice.	Oxygen	144-150	egl-9 family hypoxia inducible factor 1	Homo sapiens	19-24
23869067-5	2014	Maximum oxygen uptake was correlated directly to DL(CO) and inversely to the slope of mPpa-cardiac index relationships in both Sherpas and acclimatized lowlanders.	Oxygen	8-14	preproenkephalin	Mus musculus	86-90
24468676-5	2014	Research on PHD2 and FIH is focused on developing inhibitors and understanding the links between HIF binding and the O2 reaction in these enzymes.	Oxygen	117-119	egl-9 family hypoxia inducible factor 1	Homo sapiens	12-16
24468676-10	2014	Emerging data suggests that proteins containing a hemerythrin-domain, such as FBXL5, may serve to connect iron sensing to O2-sensing in both bacteria and humans.	Oxygen	122-124	F-box and leucine rich repeat protein 5	Homo sapiens	78-83
24658033-5	2014	Moreover, HSP40 was involved in regulating glucose metabolism on PKM2 dependent way and at the mean time had an effect on mitochondrial oxygen respiration.	Oxygen	136-142	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	10-15
24781731-9	2014	Therefore, MyHC composition has an impact on the oxygen cost of cycling both below and above the LT.	Oxygen	49-55	myosin heavy chain 6	Homo sapiens	11-15
24548970-1	2014	A bifunctional probe (PTC-Tb) which acts as not only a well-defined and stable electrochemical redox molecule but also as a highly efficient co-reactant of an electrochemiluminescent oxygen-peroxydisulfate system was firstly synthesized and applied to the construction of dual-response aptasensors for thrombin detection.	Oxygen	183-189	coagulation factor II, thrombin	Homo sapiens	302-310
24104542-6	2014	Apnea induced no change in lactatemia, but a decrease in arterial oxygen saturation in both SAp and FAp (p &lt; 0.001) was noted and a decrease in HR and swimming performance in SAp (p &lt; 0.01).	Oxygen	66-72	SH2 domain containing 1A	Homo sapiens	92-95
24375083-6	2014	RESULTS: In total, ~81% of the gene expression changes were altered in response to reoxygenation with 60 or 100% O2 and constituted many inflammatory-responsive genes (i.e., C5ar2, Stat3, and Ccl12).	Oxygen	113-115	signal transducer and activator of transcription 3	Mus musculus	181-186
24375083-6	2014	RESULTS: In total, ~81% of the gene expression changes were altered in response to reoxygenation with 60 or 100% O2 and constituted many inflammatory-responsive genes (i.e., C5ar2, Stat3, and Ccl12).	Oxygen	113-115	chemokine (C-C motif) ligand 12	Mus musculus	192-197
24631147-0	2014	Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia.	Oxygen	14-16	mechanistic target of rapamycin kinase	Homo sapiens	45-49
24631147-7	2014	RESULTS: Inhibition of PI3K and mTOR reduced oxygen consumption by cancer cell lines is predominantly due to reduction of mitochondrial respiration coupled to ATP production.	Oxygen	45-51	mechanistic target of rapamycin kinase	Homo sapiens	32-36
24631147-10	2014	CONCLUSIONS: Targeting the PI3K/mTOR pathway substantially reduces mitochondrial oxygen consumption thereby reducing tumor hypoxia.	Oxygen	81-87	mechanistic target of rapamycin kinase	Homo sapiens	32-36
24550366-0	2014	Effects of anti-VEGF treatment on the recovery of the developing retina following oxygen-induced retinopathy.	Oxygen	82-88	vascular endothelial growth factor A	Homo sapiens	16-20
24678241-1	2014	In the present study, we assessed, if the novel dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 radiosensitizes triple negative (TN) MDA-MB-231 and estrogen receptor (ER) positive MCF-7 cells to ionizing radiation under various oxygen conditions, simulating different microenvironments as occurring in the majority of breast cancers (BCs).	Oxygen	280-286	mechanistic target of rapamycin kinase	Homo sapiens	121-125
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Oxygen	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Oxygen	60-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-9	2014	In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2( )  released from the Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system.	Oxygen	98-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-130
24642865-5	2014	Nitrite (0.1 to 1.0 muM) significantly decreased the percentage of these surface markers on the platelet membrane at the hematocrit values above 23% and oxygen levels lower than 49 mmHg.	Oxygen	153-159	latexin	Homo sapiens	20-23
24599172-5	2014	The latter may be important, because very high levels of HO-1 overexpression are associated with significant oxygen cytotoxicity in vitro.	Oxygen	109-115	heme oxygenase 1	Mus musculus	57-61
24571611-9	2014	In the presence of triphenylphosphine, the "oxidized complex" proved capable of transferring one oxygen atom to phosphine, generating phosphine oxide and forming an Ir-PPh3 adduct in 92% yield.	Oxygen	97-103	caveolin 1	Homo sapiens	168-172
24618279-9	2014	Addition of LY294002 only significantly increased the O2- level in the lung and liver of the Tlr4-/- mice but not in the C57BL/6 mice following 500-mug LPS injection.	Oxygen	54-56	toll-like receptor 4	Mus musculus	93-97
24618279-12	2014	CONCLUSIONS: In this study, we demonstrate that innate resistance to LPS toxicity in Tlr4-/- mice is impaired by inhibition of the PI3K pathway, with a corresponding increase in mortality and production of tissue O2- and inflammatory cytokines.	Oxygen	213-215	toll-like receptor 4	Mus musculus	85-89
24184599-3	2014	On the basis of the effect of OPs on the ECL signal of AChE-QDs-GNs modified glassy carbon electrode (GCE), a highly sensitive GNs-anchored-QDs-based signal-on ECL biosensor was developed for sensing OPs, combined with the enzymatic reactions and the dissolved oxygen as coreactant.	Oxygen	261-267	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59
24469104-1	2014	The fructose/dioxygen biofuel cell, one of the direct electron transfer (DET)-type bioelectrochemical devices, utilizes fructose dehydrogenase (FDH) on the anode and multi-copper oxidase such as bilirubin oxidase (BOD) on the cathode as catalysts.	Oxygen	13-21	aldehyde dehydrogenase 1 family member L1	Homo sapiens	120-142
24469104-1	2014	The fructose/dioxygen biofuel cell, one of the direct electron transfer (DET)-type bioelectrochemical devices, utilizes fructose dehydrogenase (FDH) on the anode and multi-copper oxidase such as bilirubin oxidase (BOD) on the cathode as catalysts.	Oxygen	13-21	aldehyde dehydrogenase 1 family member L1	Homo sapiens	144-147
24458145-8	2014	After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated.	Oxygen	11-13	chemokine (C-C motif) ligand 12	Mus musculus	57-62
24458145-8	2014	After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated.	Oxygen	11-13	signal transducer and activator of transcription 3	Mus musculus	86-91
23984829-11	2014	Path analysis indicated that number of atoms, oxygen &amp; nitrogen atoms, and Log P are the greatest determinants for formula weight for known COX-2 inhibitors.	Oxygen	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24591714-3	2014	One of these ROS, singlet oxygen ((1)O2), activates a signalling pathway within chloroplasts that depends on the two plastid-localized proteins EXECUTER 1 and 2.	Oxygen	34-39	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	144-160
24366505-0	2014	Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass.	Oxygen	20-26	S100 calcium binding protein B	Homo sapiens	53-58
24333653-3	2014	Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1(UNCL)) or of PARP-1(24) conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-1(89) was cytotoxic.	Oxygen	125-131	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
24333653-3	2014	Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1(UNCL)) or of PARP-1(24) conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-1(89) was cytotoxic.	Oxygen	125-131	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
24333653-3	2014	Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1(UNCL)) or of PARP-1(24) conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-1(89) was cytotoxic.	Oxygen	180-186	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
24091465-4	2014	The second outcome was the nitrogen phase III slope (SN2), an index of global ventilation heterogeneity derived from the tidal nitrogen SBW test using pure oxygen.	Oxygen	156-162	solute carrier family 38 member 5	Homo sapiens	53-56
24374061-6	2014	In both models, all these changes were reversed by pre-treatment of the cells with the PPARgamma agonist, rosiglitazone, which increased mitochondrial biogenesis, increased oxygen consumption and suppressed free radical generation and autophagy.	Oxygen	173-179	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
24002459-2	2014	The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-105
24002459-2	2014	The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
24002459-5	2014	According to this hypothesis, the cell interprets the return to normoxia after a hyperoxic event as an oxygen shortage, and induces HIF-1-regulated gene synthesis, including EPO.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-137
24002459-5	2014	According to this hypothesis, the cell interprets the return to normoxia after a hyperoxic event as an oxygen shortage, and induces HIF-1-regulated gene synthesis, including EPO.	Oxygen	103-109	erythropoietin	Homo sapiens	174-177
24333653-3	2014	Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1(UNCL)) or of PARP-1(24) conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-1(89) was cytotoxic.	Oxygen	180-186	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
24446253-2	2014	Hypoxia-inducible factor-1alpha (HIF-1alpha) expression is regulated by O2 level.	Oxygen	72-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
24446253-2	2014	Hypoxia-inducible factor-1alpha (HIF-1alpha) expression is regulated by O2 level.	Oxygen	72-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
24418676-7	2014	Membrane culture resulted in increased wet mass, homogenous matrix morphology and an increase in total collagen content, while 5% oxygen culture resulted in higher GAG and type II collagen content.	Oxygen	130-136	collagen type II alpha 1 chain	Equus caballus	172-188
24366505-13	2014	Although the absolute cerebral regional saturation on cardiopulmonary bypass was not associated with S100B elevation, patients who had arterial-cerebral oxygen saturation difference greater than 50 at any time during cardiopulmonary bypass had a higher S100B peak (mean +- SE: 1.053 +- 0.080 vs 0.504 +- 0.039 ng/mL; p &lt; 0.0001).	Oxygen	153-159	S100 calcium binding protein B	Homo sapiens	253-258
24022988-4	2014	Incubation of adult rat CPCs in CdM from human MSCs isolated by plastic adherence or by magnetic sorting against CD271 (a.k.a., p75 low-affinity nerve growth factor receptor; p75MSCs) induced phosphorylation of STAT3 and Akt in CPCs, supporting their proliferation under normoxic conditions and survival under hypoxic conditions (1% oxygen).	Oxygen	333-339	signal transducer and activator of transcription 3	Homo sapiens	211-216
24375542-7	2014	Our results show that oxygen modulation does indeed contribute to enhanced maturation of PP cells, as evidenced by improved engraftment, segregation of alpha and beta cells, body weight maintenance, and rate of diabetes reversal in vivo, and by elevated expression of pancreatic endocrine makers, beta-cell differentiation yield, and insulin production in vitro.	Oxygen	22-28	insulin	Homo sapiens	334-341
24749345-5	2014	RESULTS Comparing with the RA group, we found that newborn rats exposed to 600 mL/L oxygen develop a heterogeneous parenchymal lung injury with areas of arrested alveolarization and growth mixed with areas of interstitial thinning, meanwhile, both the expression of IL-6 and IL-10 in serum and lung tissue increased significantly (P &lt; 0.05).	Oxygen	84-90	interleukin 6	Rattus norvegicus	266-270
24394419-5	2014	Using live cell imaging in a controlled oxygen environment, we observed transient 3-h pulses of HIF-1alpha and -2alpha expression under continuous hypoxia.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-118
24518819-2	2014	Previously we showed that EPOR expression in endothelial cells is increased at low oxygen tension and that EPO stimulation of endothelial cells during hypoxia can increase endothelial nitric oxide (NO) synthase (eNOS) expression and activation as well as NO production.	Oxygen	83-89	erythropoietin	Homo sapiens	26-29
24518819-12	2014	These observations provide a new effect of NO on EPOR expression to enhance EPO response in endothelial cells, particularly at low oxygen tensions.	Oxygen	131-137	erythropoietin	Homo sapiens	49-52
23682865-4	2014	BKCa is colocalized with hemeoxygenase-2, an enzyme that generates CO in the presence of O2, and CO is a BKCa channel opener.	Oxygen	89-91	heme oxygenase 2	Rattus norvegicus	25-40
24571688-0	2014	Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult.	Oxygen	58-64	apolipoprotein E	Homo sapiens	15-31
24407350-0	2014	The strong catalytic effect of Pb(II) on the oxygen reduction reaction on 5 nm gold nanoparticles.	Oxygen	45-51	submaxillary gland androgen regulated protein 3B	Homo sapiens	31-37
24555826-9	2014	Three genes significantly impact survival rates in low oxygen: cic, an ortholog of human CIC, Hsl, an ortholog of human LIPE, and Paf-AHalpha, an ortholog of human PAFAH1B3.	Oxygen	55-61	capicua transcriptional repressor	Homo sapiens	63-66
24555826-9	2014	Three genes significantly impact survival rates in low oxygen: cic, an ortholog of human CIC, Hsl, an ortholog of human LIPE, and Paf-AHalpha, an ortholog of human PAFAH1B3.	Oxygen	55-61	capicua transcriptional repressor	Homo sapiens	89-92
24555826-9	2014	Three genes significantly impact survival rates in low oxygen: cic, an ortholog of human CIC, Hsl, an ortholog of human LIPE, and Paf-AHalpha, an ortholog of human PAFAH1B3.	Oxygen	55-61	platelet activating factor acetylhydrolase 1b catalytic subunit 3	Homo sapiens	164-172
24533077-9	2014	Interestingly, IL-6-/- mice displayed important adaptive mechanisms including significantly lower oxygen cost of running at a given speed accompanied by lower expression of sarcoplasmic reticulum Ca2+-ATPase and lower plasma lactate concentrations during running at submaximal and maximal running velocities.	Oxygen	98-104	interleukin 6	Mus musculus	15-19
24564828-1	2014	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1), a master regulator of oxygen homeostasis, is a heterodimer consisting of HIF-1alpha and HIF-1beta subunits, and is implicated in calcification of cartilage and vasculature.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
24564828-1	2014	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1), a master regulator of oxygen homeostasis, is a heterodimer consisting of HIF-1alpha and HIF-1beta subunits, and is implicated in calcification of cartilage and vasculature.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
24578615-3	2014	METHODS AND RESULTS: Hypoxia (10.5% O2) treatment of pregnant rats from day 15 to day 21 resulted in a significant increase in prepro-ET-1 mRNA expression in fetal hearts.	Oxygen	36-38	endothelin 1	Rattus norvegicus	134-138
24363306-12	2014	miR-1, -133a, and -206 correlated to aerobic performance parameters such as maximum oxygen uptake (VO(2max)) and running speed at individual anaerobic lactate threshold (VIAS).	Oxygen	84-90	mir-1	Caenorhabditis elegans	0-5
24134622-4	2014	Exposure of hASCs for 10 days under hypoxia (3% oxygen) in combination with leptin increased the percentage of CD31(+) endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor, and endothelial cell nitric oxide synthase mRNA expression.	Oxygen	48-54	cadherin 5	Homo sapiens	154-165
24135452-9	2014	The ABCB1-dependent ATPase activity stimulated by nitensidine A was greatly reduced by substituting sulfur (S) or oxygen (O) for the imino nitrogen atom (N) in nitensidine A.	Oxygen	114-120	ATP binding cassette subfamily B member 1	Homo sapiens	4-9
24322607-0	2014	Inducible nitric oxide synthase inhibits oxygen consumption in collateral-dependent myocardium.	Oxygen	41-47	nitric oxide synthase 2	Homo sapiens	0-31
24066808-3	2014	We determined that sustained NF-kappaB activity mediated by IkappaBbeta attenuates lung injury and prevents mortality in adult mice exposed to greater than 95% O2.	Oxygen	160-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
24322607-8	2014	Thus the coordinated expression of iNOS to restrain MVo2 and eNOS to maintain collateral vasodilation act to optimize the O2 supply-demand relationship and protect the collateralized myocardium from ischemia.	Oxygen	122-124	nitric oxide synthase 2	Homo sapiens	35-39
23443522-1	2014	The misuse of recombinant human erythropoietin (rhEPO) increases the proliferation/production of erythrocytes, which enhance oxygen transport capacities, and has grave consequences with respect to human health and fairness in sports.	Oxygen	125-131	erythropoietin	Homo sapiens	32-46
24510989-4	2014	HIF1 is a heterodimeric transcriptional complex that functions as the main regulator of systemic and cellular oxygen homeostasis; it is composed of HIF1alpha and HF1beta subunits.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-4
24510989-5	2014	At physiological concentrations of oxygen, prolyl hydroxylases (PHDs) modify HIF1alpha and prepare it for proteasomal degradation.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-86
24198163-0	2014	Oxygen at a high flow rate (35 L min -1) via face mask for preoxygenation.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	33-39
24374034-2	2014	It has been shown that the levels of peroxisome proliferator-activated receptor gamma (PPARgamma) are influenced by changes in oxygen tension, and PPARgamma plays a critical role in metabolism regulation and cancers.	Oxygen	127-133	peroxisome proliferator activated receptor gamma	Homo sapiens	37-85
24374034-2	2014	It has been shown that the levels of peroxisome proliferator-activated receptor gamma (PPARgamma) are influenced by changes in oxygen tension, and PPARgamma plays a critical role in metabolism regulation and cancers.	Oxygen	127-133	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
24794724-1	2014	Serine/threonine protein kinase mTOR regulates the maintenance of cellular homeostasis by coordinating transcription, translation, metabolism, and autophagy with availability of amino acids, growth factors, ATP, and oxygen.	Oxygen	216-222	mechanistic target of rapamycin kinase	Homo sapiens	32-36
24292632-1	2014	PURPOSE: Hypoxia-inducible factor-1 (HIF-1) facilitates the adaptation of normal and tumor tissues to oxygen deprivation.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-35
24292632-1	2014	PURPOSE: Hypoxia-inducible factor-1 (HIF-1) facilitates the adaptation of normal and tumor tissues to oxygen deprivation.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
25419449-1	2014	We report mechanistic aspects of the trapping of thermally (HDDA) generated benzyne derivatives by pendant silyl ether groups, which results in net insertion of the pair of benzyne Csp-hydribized carbon atoms into the silicon-oxygen sigma bond.	Oxygen	226-232	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	181-184
23949111-5	2014	The inputs with the greatest effect were those related to oxygen content (NO3) or oxygen demand (NH3-NL).	Oxygen	58-64	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
24184535-2	2014	SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of catalase to disproportionate H2O2 to O2, and has obvious effect on the proliferation of HepG-2 cells in 72 h. Moreover, the two nanoparticles show some inhibition on the expression of hypoxia inducible factor (HIF-1alpha), glucose transporter (GLUT1) and the production of lactate in HepG-2 cells.	Oxygen	2-4	catalase	Homo sapiens	110-118
24184535-2	2014	SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of catalase to disproportionate H2O2 to O2, and has obvious effect on the proliferation of HepG-2 cells in 72 h. Moreover, the two nanoparticles show some inhibition on the expression of hypoxia inducible factor (HIF-1alpha), glucose transporter (GLUT1) and the production of lactate in HepG-2 cells.	Oxygen	2-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	320-330
24259533-0	2014	LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes.	Oxygen	37-43	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-8
23736373-14	2014	Treatment of WA with FGF21-induced UCP1 expression and increased oxygen consumption, respiratory uncoupling, norepinephrine-mediated thermogenesis, fatty acid oxidation and heat production, thus recapitulating the association between cold-induced FGF21 secretion and cold-induced thermogenesis in vivo.	Oxygen	65-71	fibroblast growth factor 21	Homo sapiens	21-26
23966271-1	2014	Hypoxia-inducible factor (HIF)-1alpha mediates the hypoxia response signaling pathway essential for maintaining cellular homeostasis in low oxygen environments through its complex formation with CBP/p300 in the nucleus.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
23966271-1	2014	Hypoxia-inducible factor (HIF)-1alpha mediates the hypoxia response signaling pathway essential for maintaining cellular homeostasis in low oxygen environments through its complex formation with CBP/p300 in the nucleus.	Oxygen	140-146	CREB binding protein	Homo sapiens	195-203
24355658-1	2014	PURPOSE: To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD).	Oxygen	47-53	CTD	Homo sapiens	194-197
24355658-1	2014	PURPOSE: To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD).	Oxygen	64-66	CTD	Homo sapiens	194-197
24355658-9	2014	CONCLUSION: O2-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD.	Oxygen	12-14	CTD	Homo sapiens	138-141
24103013-7	2014	In addition, high oxygen tension during in vitro culture (IVC) with RDCM significantly increases the mRNA expression of oxidative stress-related genes (GPX-1, SOD-1, CAT and GSS) (P &lt; 0.05).	Oxygen	18-24	glutathione peroxidase 1	Bos taurus	152-157
24601117-4	2014	Spinal anesthesia was performed with bupivacaine 12.5 mg. At the beginning of anesthesia SPO2 was 97% in supine position, but it rapidly decreased to less than 90% and 3 l x min(-1) oxygen was supplied with a facial mask.	Oxygen	182-188	CD59 molecule (CD59 blood group)	Homo sapiens	174-180
24226635-5	2014	The O2 treatment was &gt;95% O2 for 7 d, followed by 60% O2 for 14 d. RESULTS: Rat pups born to LPS-injected dams exhibited significantly higher lung interferon-gamma and interleukin-1beta (IL-1beta) on postnatal day 7 than the pups born to NS-injected dams.	Oxygen	4-6	interleukin 1 beta	Rattus norvegicus	171-188
24226635-5	2014	The O2 treatment was &gt;95% O2 for 7 d, followed by 60% O2 for 14 d. RESULTS: Rat pups born to LPS-injected dams exhibited significantly higher lung interferon-gamma and interleukin-1beta (IL-1beta) on postnatal day 7 than the pups born to NS-injected dams.	Oxygen	4-6	interleukin 1 beta	Rattus norvegicus	190-198
24123616-0	2014	Physiological oxygen prevents frequent silencing of the DLK1-DIO3 cluster during human embryonic stem cells culture.	Oxygen	14-20	delta like non-canonical Notch ligand 1	Homo sapiens	56-60
24123616-0	2014	Physiological oxygen prevents frequent silencing of the DLK1-DIO3 cluster during human embryonic stem cells culture.	Oxygen	14-20	iodothyronine deiodinase 3	Homo sapiens	61-65
24123616-5	2014	Furthermore, we demonstrated that 5% oxygen, instead of the commonly used 20% oxygen, is required for preserving the expression of the DLK1-DIO3 cluster.	Oxygen	37-43	delta like non-canonical Notch ligand 1	Homo sapiens	135-139
24123616-5	2014	Furthermore, we demonstrated that 5% oxygen, instead of the commonly used 20% oxygen, is required for preserving the expression of the DLK1-DIO3 cluster.	Oxygen	37-43	iodothyronine deiodinase 3	Homo sapiens	140-144
24516756-7	2014	RESULTS: Cellular oxygen consumption was inhibited by 2.5 muM and 25 muM of AFB1.	Oxygen	18-24	latexin	Homo sapiens	58-61
24516756-7	2014	RESULTS: Cellular oxygen consumption was inhibited by 2.5 muM and 25 muM of AFB1.	Oxygen	18-24	latexin	Homo sapiens	69-72
24123616-6	2014	Overall, the data suggest that active expression of the DLK1-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.	Oxygen	196-202	delta like non-canonical Notch ligand 1	Homo sapiens	56-60
24123616-6	2014	Overall, the data suggest that active expression of the DLK1-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.	Oxygen	196-202	iodothyronine deiodinase 3	Homo sapiens	61-65
24739646-7	2014	CONCLUSIONS: The expression of miR-155 and HIF-1alpha is topically stimulated by oxygen signal.HIF-1alpha adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
24739646-7	2014	CONCLUSIONS: The expression of miR-155 and HIF-1alpha is topically stimulated by oxygen signal.HIF-1alpha adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
24739646-7	2014	CONCLUSIONS: The expression of miR-155 and HIF-1alpha is topically stimulated by oxygen signal.HIF-1alpha adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.	Oxygen	81-87	vascular endothelial growth factor A	Homo sapiens	151-155
24761603-2	2014	PHD2 plays a critical role in cells and tissues adaptation to the low oxygen environment.	Oxygen	70-76	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
24489651-13	2014	Growth of cells in 1% O2 induced elevated HIF1alpha, BCRP and MDR-1 protein, and these cells were resistant to DOX.	Oxygen	22-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-51
24489651-13	2014	Growth of cells in 1% O2 induced elevated HIF1alpha, BCRP and MDR-1 protein, and these cells were resistant to DOX.	Oxygen	22-24	ATP binding cassette subfamily B member 1	Homo sapiens	62-67
24457964-6	2014	In this study, we found that in the human glioblastoma cell lines U87MG and U138MG, IL-1beta inhibits the transactivation activity of HIF-1 by promoting the ubiquitin-independent proteasomal degradation of the oxygen-labile alpha-subunit of HIF-1 and downregulates the expression of the HIF-1 target gene adrenomedullin (AM).	Oxygen	210-216	interleukin 1 beta	Homo sapiens	84-92
24457964-6	2014	In this study, we found that in the human glioblastoma cell lines U87MG and U138MG, IL-1beta inhibits the transactivation activity of HIF-1 by promoting the ubiquitin-independent proteasomal degradation of the oxygen-labile alpha-subunit of HIF-1 and downregulates the expression of the HIF-1 target gene adrenomedullin (AM).	Oxygen	210-216	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
24299758-3	2014	The water adsorption of the CMKGM/SPI films progressively decreased with increasing CMKGM level, the surface wettability of the blended films was improved with increasing CMKGM content; the CMKGM/SPI blend films had enhanced tensile strength (TS) and elongation at break (EAB) compared to pure CMKGM and SPI films; the oxygen permeability of blend films was decreased; the roughness was decreased with increasing CMKGM content.	Oxygen	319-325	chromogranin A	Homo sapiens	196-199
24761603-4	2014	Subsequently, PHD2 acts as an important factor in oxygen homeostasis.	Oxygen	50-56	egl-9 family hypoxia inducible factor 1	Homo sapiens	14-18
24262762-9	2014	The reduction in CRP levels correlated with the improvement in peak oxygen consumption (R = -0.60, p = 0.002).	Oxygen	68-74	C-reactive protein	Homo sapiens	17-20
24466056-1	2014	Lactate dehydrogenase A (LDHA) is an important enzyme in fermentative glycolysis, generating most energy for cancer cells that rely on anaerobic respiration even under normal oxygen concentrations.	Oxygen	175-181	lactate dehydrogenase A	Homo sapiens	0-23
24466056-1	2014	Lactate dehydrogenase A (LDHA) is an important enzyme in fermentative glycolysis, generating most energy for cancer cells that rely on anaerobic respiration even under normal oxygen concentrations.	Oxygen	175-181	lactate dehydrogenase A	Homo sapiens	25-29
24309216-12	2014	Adenosine and 1% oxygen induce vasorelaxation in PGF2alpha-contracted porcine coronary arteries partly by force suppression caused by increased cAMP and phosphorylation of HSP20.	Oxygen	17-23	heat shock protein family B (small) member 6	Homo sapiens	172-177
24439383-4	2014	Rather, mature glomus cells expressing endothelin-1, the O2-sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth.	Oxygen	57-59	endothelin 1	Homo sapiens	39-51
24439383-4	2014	Rather, mature glomus cells expressing endothelin-1, the O2-sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth.	Oxygen	57-59	endothelin 1	Homo sapiens	39-49
24309216-8	2014	1% oxygen or adenosine increased cAMP accumulation and HSP20 phosphorylation without changing T850-MYPT1 and MLC phosphorylation.	Oxygen	3-9	heat shock protein family B (small) member 6	Homo sapiens	55-60
24551277-7	2014	HeLa and SiHa cells cultured in 1% oxygen showed the increased viability and apoptosis, and the former effect could be partly reversed by anti-human IL-8 neutralizing antibody.	Oxygen	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24076356-2	2014	Myoglobin is an oxygen-binding cytoplasmic hemoprotein that is abundantly expressed in oxidative skeletal and cardiac myocytes.	Oxygen	16-22	myoglobin	Pantholops hodgsonii	0-9
24482687-4	2014	The mRNA and protein expression of IL-6, MCP-1 and SePP1 were detected in preadipocytes under normoxic (21% O2) and hyperoxic (4% O2) conditions, and the impact of IL-6, MCP-1 and SePP1 on VF was investigated.	Oxygen	108-110	interleukin 6	Rattus norvegicus	35-39
24482687-4	2014	The mRNA and protein expression of IL-6, MCP-1 and SePP1 were detected in preadipocytes under normoxic (21% O2) and hyperoxic (4% O2) conditions, and the impact of IL-6, MCP-1 and SePP1 on VF was investigated.	Oxygen	130-132	interleukin 6	Rattus norvegicus	35-39
24076356-9	2014	But these amino acid substitutions are unlikely to effect the ability of binding oxygen because their location is less important, which is revealed by the secondary structure and 3D structure of TA myoglobin elaborated by homology modeling.	Oxygen	81-87	myoglobin	Pantholops hodgsonii	198-207
24076356-11	2014	We speculated that the higher expression of myoglobin in TA cardiac and skeletal muscles improves their ability to obtain and store oxygen under hypoxic conditions.	Oxygen	132-138	myoglobin	Pantholops hodgsonii	44-53
24178759-6	2014	RESULTS: Lactate dehydrogenase A was significantly increased under hypoxic conditions (1% O2), where the novel LDH-A inhibitors proved to be particularly effective (e.g., with IC50 values of 0.9 vs 16.3 muM for NHI-1 in LPC006 in hypoxia vs normoxia, respectively).	Oxygen	90-92	lactate dehydrogenase A	Homo sapiens	9-32
23318445-7	2014	In turn, overexpression of SOD1 could rescue oxygen consumption rate in FA-deficient cells.	Oxygen	45-51	superoxide dismutase 1	Homo sapiens	27-31
24178759-6	2014	RESULTS: Lactate dehydrogenase A was significantly increased under hypoxic conditions (1% O2), where the novel LDH-A inhibitors proved to be particularly effective (e.g., with IC50 values of 0.9 vs 16.3 muM for NHI-1 in LPC006 in hypoxia vs normoxia, respectively).	Oxygen	90-92	lactate dehydrogenase A	Homo sapiens	111-116
25478170-4	2014	Blood oxygen levels negatively correlate with 7 of 10 quantitative markers of murine lung injury, including neutrophilia and interleukin-6 expression.	Oxygen	6-12	interleukin 6	Mus musculus	125-138
24275138-4	2014	p53 Silencing decreased survival of glucose-starved C8161 melanoma with pyruvate supplementation under hypoxia (&lt;=1% oxygen), but increased resistance to glycolytic inhibitors oxamate and 2-deoxyglucose in 5mM glucose, preferentially under normoxia.	Oxygen	120-126	tumor protein p53	Homo sapiens	0-3
24091497-9	2014	We further observed that DKK1 diminished retinal vessel density and increased avascular area in an in vivo murine model of oxygen-induced retinopathy, whereas DKK2 showed opposite results.	Oxygen	123-129	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	25-29
24729228-0	2014	Angiotensin II reduces transport-dependent oxygen consumption but increases transport-independent oxygen consumption in immortalized mouse proximal tubular cells.	Oxygen	43-49	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
24729228-0	2014	Angiotensin II reduces transport-dependent oxygen consumption but increases transport-independent oxygen consumption in immortalized mouse proximal tubular cells.	Oxygen	98-104	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
24729228-2	2014	Angiotensin II (Ang II) can activate the NADPH-oxidase, increasing oxidative stress that is thought to blunt proximal tubular electrolyte transport and thereby oxygen consumption (QO2).	Oxygen	160-166	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
24729228-2	2014	Angiotensin II (Ang II) can activate the NADPH-oxidase, increasing oxidative stress that is thought to blunt proximal tubular electrolyte transport and thereby oxygen consumption (QO2).	Oxygen	160-166	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	16-22
23988176-3	2014	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
23988176-3	2014	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24809065-0	2014	Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland.	Oxygen	8-14	insulin like growth factor 1	Homo sapiens	189-193
24749309-2	2014	The mean pulmonary oxygen consumption was higher than the same value calculated by the reverse Fick principle--148.4 +/- 39.9 ml x min(-1) x m(-2) and 120 +/- 35.1 ml x min(-1) x m(-2), respectively, the mean difference between two methods was 28.4 +/- 18.4 ml x min(-1) x m(-2).	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	131-137
24749309-2	2014	The mean pulmonary oxygen consumption was higher than the same value calculated by the reverse Fick principle--148.4 +/- 39.9 ml x min(-1) x m(-2) and 120 +/- 35.1 ml x min(-1) x m(-2), respectively, the mean difference between two methods was 28.4 +/- 18.4 ml x min(-1) x m(-2).	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	169-175
24749309-2	2014	The mean pulmonary oxygen consumption was higher than the same value calculated by the reverse Fick principle--148.4 +/- 39.9 ml x min(-1) x m(-2) and 120 +/- 35.1 ml x min(-1) x m(-2), respectively, the mean difference between two methods was 28.4 +/- 18.4 ml x min(-1) x m(-2).	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	169-175
23988176-4	2014	HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
24097299-1	2014	Solid tumors supply oxygen and nutrients required for angiogenesis by producing vascular endothelial growth factor (VEGF).	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	80-114
24097299-1	2014	Solid tumors supply oxygen and nutrients required for angiogenesis by producing vascular endothelial growth factor (VEGF).	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	116-120
23953010-0	2014	Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34+ cells in a murine model of umbilical cord blood transplantation.	Oxygen	11-17	CD34 molecule	Homo sapiens	85-89
23725018-4	2014	Herein we aimed to study the possible role of nSMase-derived ceramide as a common factor in the acute oxygen-sensing function of specialized vascular tissues.	Oxygen	102-108	sphingomyelin phosphodiesterase 2	Gallus gallus	46-52
23725018-11	2014	INNOVATION: These data provide evidence for the proposal that nSMase-derived ceramide is a critical player in acute oxygen-sensing in specialized vascular tissues.	Oxygen	116-122	sphingomyelin phosphodiesterase 2	Gallus gallus	62-68
25366488-0	2014	Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy.	Oxygen	88-94	mechanistic target of rapamycin kinase	Homo sapiens	27-56
25366488-2	2014	In the present study, we examined the effects of rapamycin and everolimus, inhibitors of mammalian target of rapamycin (mTOR), on retinal pathologic angiogenesis in mice with oxygen-induced retinopathy (OIR), an animal model of proliferative ischemic retinopathy.	Oxygen	175-181	mechanistic target of rapamycin kinase	Homo sapiens	120-124
24649080-0	2014	Angiotensin II protects cortical neurons against oxygen-glucose deprivation-induced injury in vitro.	Oxygen	49-55	angiotensinogen	Homo sapiens	0-14
25180188-5	2014	Transferrin and iron levels presented high values related to an overstimulation of the liver, a normal renal function, a tendency to decrease flexibility, and an increase in aerobic capacity, finding a tendency to increase the absolute maximal oxygen uptake (37.2 +-2.4 versus 38.7 +- 1.8 mL/min) in contrast to previous studies conducted with subjects with similar age.	Oxygen	244-250	transferrin	Homo sapiens	0-11
24369116-4	2014	Our results show considerable differences in H43R compared to WT and W32F mutated SOD1, such as increasing distances between the critical residues results in open conformation at the active site, strong fluctuations in the important loops (Zinc and electrostatic loops) and weakening of important hydrogen bonds especially between N (His 43/Arg 43) and carbonyl oxygen (His 120) in agreement with the experimental report.	Oxygen	362-368	superoxide dismutase 1	Homo sapiens	82-86
24275025-6	2014	These removals were higher than those previously obtained in mini-MEC tests, as oxygen crossover from the cathode enhanced degradation in MFCs compared to MECs.	Oxygen	80-86	C-C motif chemokine ligand 28	Homo sapiens	66-69
24819865-3	2014	Most attention has been focused on the NO generating pathways within the endothelium; however, the recent discovery of a NO synthase (NOS)-like enzyme residing in red blood cells (RBC) has increased our understanding of the blood flow and oxygen delivery modulation by RBC.	Oxygen	239-245	nitric oxide synthase 2	Homo sapiens	121-132
24381864-6	2014	A feedback mechanism involving oxygen delivery to the tissues seems to regulate erythropoietin production.	Oxygen	31-37	erythropoietin	Homo sapiens	80-94
24894165-2	2014	Tumor cells respond to hypoxia by activating several oxygen-sensitive signaling pathways that include the hypoxia inducible factor 1/2 (HIF1/2) signalling pathways and the unfolded protein response (UPR), which alter gene expression to promote adaptation and survival during hypoxic conditions.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-142
24552809-0	2014	Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.	Oxygen	101-107	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	0-35
24552809-0	2014	Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.	Oxygen	101-107	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	37-41
24552809-3	2014	In this study, we found that even at a representative physiological concentration of 3% O2, Ppm1d(-/-) MEFs underwent premature cellular senescence that depended on the functional activation of p53.	Oxygen	88-90	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	92-97
24552809-7	2014	These findings suggest that Wip1 prevents the induction of cellular senescence at physiological oxygen levels by attenuating DDR signaling in response to endogenous double-stranded breaks that form during DNA replication.	Oxygen	96-102	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	28-32
24496287-6	2014	RESULTS: Atmospheric oxygen, or removal of FGF2 from hESCs cultured at 5% oxygen, perturbed the uptake or release of individual amino acids and the total amino acid turnover compared to hESCs cultured at 5% oxygen.	Oxygen	74-80	fibroblast growth factor 2	Homo sapiens	43-47
24496287-6	2014	RESULTS: Atmospheric oxygen, or removal of FGF2 from hESCs cultured at 5% oxygen, perturbed the uptake or release of individual amino acids and the total amino acid turnover compared to hESCs cultured at 5% oxygen.	Oxygen	74-80	fibroblast growth factor 2	Homo sapiens	43-47
26155140-4	2014	In TLR4-/- HF mice, the O2 consumption, CO2 production and activities were higher than in the WT HF group.	Oxygen	24-26	toll-like receptor 4	Mus musculus	3-7
24357688-5	2014	As well as providing a conduit for delivery of the primary input stimulus (glucose) and dissemination of its most important effector (insulin), intraislet blood vessels deliver oxygen to these dense clusters of metabolically active cells.	Oxygen	177-183	insulin	Homo sapiens	134-141
25273051-6	2014	The results of this study suggest that TZP surface treated with oxygen plasma promotes the initial attachment capability of human oral keratinocytes with enhancing the extracellular matrix such as laminin gamma2.	Oxygen	64-70	laminin subunit gamma 2	Homo sapiens	197-211
24009260-7	2014	Three hours of insulin treatment increased Opa-1 protein levels, promoted mitochondrial fusion, increased mitochondrial membrane potential, and elevated both intracellular ATP levels and oxygen consumption in cardiomyocytes in vitro and in vivo.	Oxygen	187-193	insulin	Homo sapiens	15-22
24404861-4	2014	High-intensity interval training had a beneficial effect on maximal O2 uptake (mean change, +-90% confidence intervals: 0.19 L   min(-1), +-0.19, respectively), on the O2 uptake at the gas exchange threshold (0.09 L   min(-1), +-0.13) and on the O2 cost of sub-maximal exercise (-0.04 L   min(-1), +-0.04).	Oxygen	68-70	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
25335240-6	2014	The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.	Oxygen	168-174	uncharacterized protein	Drosophila melanogaster	310-317
25803753-1	2014	The purpose of the current study was to determine the effects of three different pulse durations (200, 350, and 500 microseconds [P200, P350, and P500, respectively]) on oxygen uptake (VO2), cycling performance, and energy expenditure (EE) percentage of fatigue of the knee extensor muscle group immediately and 48 to 72 h after cycling in persons with spinal cord injury (SCI).	Oxygen	170-176	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	136-140
25803753-1	2014	The purpose of the current study was to determine the effects of three different pulse durations (200, 350, and 500 microseconds [P200, P350, and P500, respectively]) on oxygen uptake (VO2), cycling performance, and energy expenditure (EE) percentage of fatigue of the knee extensor muscle group immediately and 48 to 72 h after cycling in persons with spinal cord injury (SCI).	Oxygen	170-176	C-C motif chemokine ligand 1	Homo sapiens	146-150
24949080-9	2014	Importantly, THSWD"s protection against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by antioxidant response element (ARE) decoy oligonucleotides, suggesting the protection of THSWD may be likely regulated at least in part by Nrf2-mediated phase II enzymes.	Oxygen	40-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	278-282
24166752-6	2014	At 16 weeks, hearts from O(2)-exposed rats showed cardiomyocyte hypertrophy, enhanced fibrosis, and increased expression of transforming growth factor-beta1, senescence-associated proteins p53 and Rb, upregulation of angiotensin II type 1 (AT1) receptor expression (protein and AT1a/b mRNA), and downregulation of AT2 receptors.	Oxygen	25-29	angiotensin II receptor, type 1b	Rattus norvegicus	217-253
24166752-7	2014	At 4 weeks (before blood pressure increase), the expression of cardiomyocyte surface area, fibrosis, p53, and AT1b was significantly increased and AT2 decreased in O(2)-exposed animals.	Oxygen	164-168	angiotensin II receptor, type 1b	Rattus norvegicus	110-114
24166752-8	2014	After 4 weeks of continuous angiotensin II infusion (starting at 12 weeks), O(2)-exposed rats developed severe heart failure, with impaired myocardial mechanical properties compared with saline-infused rats.	Oxygen	76-80	angiotensinogen	Rattus norvegicus	28-42
25165472-2	2014	Our results showed significant positive correlations between circulating testosterone and insulin growth factor-1 (IGF-1) with knee flexion, knee extension, one-repetition maximum (1-RM), and peak oxygen consumption (VO2 peak), while no correlation was observed with estradiol.	Oxygen	197-203	insulin like growth factor 1	Homo sapiens	90-113
25165472-2	2014	Our results showed significant positive correlations between circulating testosterone and insulin growth factor-1 (IGF-1) with knee flexion, knee extension, one-repetition maximum (1-RM), and peak oxygen consumption (VO2 peak), while no correlation was observed with estradiol.	Oxygen	197-203	insulin like growth factor 1	Homo sapiens	115-120
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	235-237	steroidogenic acute regulatory protein	Bos taurus	96-134
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	235-237	steroidogenic acute regulatory protein	Bos taurus	136-140
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	346-348	steroidogenic acute regulatory protein	Bos taurus	96-134
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	346-348	steroidogenic acute regulatory protein	Bos taurus	136-140
24558938-2	2014	On admission, Glasgow Coma Scale score was 7; arterial blood pressure was 113/73 mm Hg; heart rate was 157 beats x min(-1), and percutaneous oxygen saturation was 99% on 10 l x min(-1) of oxygen.	Oxygen	188-194	CD59 molecule (CD59 blood group)	Homo sapiens	177-183
24114661-0	2014	Pyrroloquinoline quinone inhibits oxygen/glucose deprivation-induced apoptosis by activating the PI3K/AKT pathway in cardiomyocytes.	Oxygen	34-40	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	CD33 molecule	Homo sapiens	249-252
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	AKT serine/threonine kinase 1	Homo sapiens	296-299
25138030-6	2014	RESULTS: Cultured Muller cells secrete TSP-1 under normoxic and hypoxic (0.2% O2) conditions.	Oxygen	78-80	thrombospondin 1	Homo sapiens	39-44
23954169-0	2014	Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.	Oxygen	203-209	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-60
24410431-2	2014	Vascular endothelial growth factor (VEGF) promotes this growth by stimulating endothelial cells, which form vessel walls and transport nutrients and oxygen to tissues.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	0-34
24410431-2	2014	Vascular endothelial growth factor (VEGF) promotes this growth by stimulating endothelial cells, which form vessel walls and transport nutrients and oxygen to tissues.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	36-40
23998203-6	2014	The aryl hydrocarbon receptor (AhR) mediates the cellular response to some pollutants, while hypoxia responses occur through the oxygen-sensitive transcription factor hypoxia-inducible factor (HIF)-1.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-199
24955212-0	2014	Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway.	Oxygen	32-38	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
24955212-0	2014	Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway.	Oxygen	32-38	NFE2 like bZIP transcription factor 2	Rattus norvegicus	111-115
24955212-7	2014	Importantly, the protective effect of PTS against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by PI3K inhibitor and antioxidant response element (ARE) decoy oligonucleotides, suggesting that both PI3K/Akt and Nrf2 signaling pathway are essential during this protective process.	Oxygen	50-56	AKT serine/threonine kinase 1	Rattus norvegicus	254-257
24955212-7	2014	Importantly, the protective effect of PTS against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by PI3K inhibitor and antioxidant response element (ARE) decoy oligonucleotides, suggesting that both PI3K/Akt and Nrf2 signaling pathway are essential during this protective process.	Oxygen	50-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	262-266
24517755-1	2014	This paper focuses on the surprising discovery of multiple species of ionization-created CS2 anions in gas mixtures containing electronegative CS2 and O2, identified by their slightly different drift velocities.	Oxygen	151-153	chorionic somatomammotropin hormone 2	Homo sapiens	89-92
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-104
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	178-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-104
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	178-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
23574450-0	2014	Analysis of the role of the pyruvate decarboxylase gene family in Arabidopsis thaliana under low-oxygen conditions.	Oxygen	97-103	pyruvate decarboxylase-2	Arabidopsis thaliana	28-50
23574450-4	2014	The availability of microarray data sets enabled the relative importance of the four PDC genes under low oxygen to be assessed, and revealed that, contrary to previous published evidence, not only PDC1 but also PDC2 plays a role under hypoxic conditions.	Oxygen	105-111	pyruvate decarboxylase-2	Arabidopsis thaliana	85-88
23574450-4	2014	The availability of microarray data sets enabled the relative importance of the four PDC genes under low oxygen to be assessed, and revealed that, contrary to previous published evidence, not only PDC1 but also PDC2 plays a role under hypoxic conditions.	Oxygen	105-111	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	197-201
23574450-4	2014	The availability of microarray data sets enabled the relative importance of the four PDC genes under low oxygen to be assessed, and revealed that, contrary to previous published evidence, not only PDC1 but also PDC2 plays a role under hypoxic conditions.	Oxygen	105-111	pyruvate decarboxylase-2	Arabidopsis thaliana	211-215
23574450-7	2014	The expression of both PDC1 and PDC2 is strongly up-regulated under low oxygen.	Oxygen	72-78	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	23-27
23574450-7	2014	The expression of both PDC1 and PDC2 is strongly up-regulated under low oxygen.	Oxygen	72-78	pyruvate decarboxylase-2	Arabidopsis thaliana	32-36
24741770-2	2014	Studies have revealed that mutant huntingtin, polyglutamine-expanded ataxin-1 and ataxin-3 can cause elevated levels of reactive oxygen species in neuronal cells.	Oxygen	129-135	ataxin 1	Homo sapiens	69-77
24183749-0	2014	Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats.	Oxygen	80-86	gap junction protein, alpha 1	Rattus norvegicus	19-23
24291646-0	2014	Hyperbaric oxygen promotes osteogenic differentiation of bone marrow stromal cells by regulating Wnt3a/beta-catenin signaling--an in vitro and in vivo study.	Oxygen	11-17	protein Wnt-3a	Oryctolagus cuniculus	97-102
24291646-0	2014	Hyperbaric oxygen promotes osteogenic differentiation of bone marrow stromal cells by regulating Wnt3a/beta-catenin signaling--an in vitro and in vivo study.	Oxygen	11-17	LOC100125986	Oryctolagus cuniculus	103-115
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	endothelin 1	Homo sapiens	222-234
24291646-1	2014	We hypothesized that the effect of hyperbaric oxygen (HBO) on bone formation is increased via osteogenic differentiation of bone marrow stromal cells (BMSCs), which is regulated by Wnt3a/beta-catenin signaling.	Oxygen	46-52	protein Wnt-3a	Oryctolagus cuniculus	181-186
24291646-1	2014	We hypothesized that the effect of hyperbaric oxygen (HBO) on bone formation is increased via osteogenic differentiation of bone marrow stromal cells (BMSCs), which is regulated by Wnt3a/beta-catenin signaling.	Oxygen	46-52	LOC100125986	Oryctolagus cuniculus	187-199
24374914-8	2014	The experimental evidences indicate that (1)O2 is generated at a yield close to 10 % by the Russell mechanism from LOOH, either free or in membranes, in the presence of biologically relevant oxidants, such as metal ions, peroxynitrite, HOCl and cytochrome c.	Oxygen	41-46	cytochrome c, somatic	Homo sapiens	245-257
25201196-0	2014	Crosstalk between Mdm2, p53 and HIF1-alpha: distinct responses to oxygen stress and implications for tumour hypoxia.	Oxygen	66-72	tumor protein p53	Homo sapiens	24-27
25201196-0	2014	Crosstalk between Mdm2, p53 and HIF1-alpha: distinct responses to oxygen stress and implications for tumour hypoxia.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	interleukin 6	Homo sapiens	236-240
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	242-246
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	tumor necrosis factor	Homo sapiens	251-260
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	vascular endothelial growth factor A	Homo sapiens	303-309
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	fibroblast growth factor 2	Homo sapiens	314-318
24511349-0	2013	CKM Gene G (Ncoi-) Allele Has a Positive Effect on Maximal Oxygen Uptake in Caucasian Women Practicing Sports Requiring Aerobic and Anaerobic Exercise Metabolism.	Oxygen	59-65	creatine kinase, M-type	Homo sapiens	0-3
24511349-5	2013	The study revealed a positive effect of a rare G (NcoI-) allele of the CKM gene on maximal oxygen uptake in Caucasian women practicing sports requiring aerobic and anaerobic exercise metabolism.	Oxygen	91-97	creatine kinase, M-type	Homo sapiens	71-74
24155240-8	2013	Treatment with a PPARalpha antagonist indicates that the increase in UCP1 expression and oxygen consumption is PPARalpha-dependent.	Oxygen	89-95	peroxisome proliferator activated receptor alpha	Mus musculus	17-26
24274590-5	2013	Singlet oxygen ((1)O2) reaction kinetics of individual photooxidizable residues in the protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were examined.	Oxygen	16-21	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	95-135
24274590-5	2013	Singlet oxygen ((1)O2) reaction kinetics of individual photooxidizable residues in the protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were examined.	Oxygen	16-21	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	137-142
24155240-8	2013	Treatment with a PPARalpha antagonist indicates that the increase in UCP1 expression and oxygen consumption is PPARalpha-dependent.	Oxygen	89-95	peroxisome proliferator activated receptor alpha	Mus musculus	111-120
24089376-0	2013	Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.	Oxygen	52-54	insulin	Homo sapiens	23-32
24349516-7	2013	Furthermore, there were differential changes in levels of beclin-1, DRAM, and LC3B-II in response to changes in oxygen and glucose levels.	Oxygen	112-118	DNA damage regulated autophagy modulator 1	Homo sapiens	68-72
23973669-6	2013	We found that Snail1-enriched HBL-100 cells were less sensitive to hypoxia-induced growth suppression if compared with MCF-7 line (31% MCF-7 vs. 71% HBL-100 cell viability after 1% O2 atmosphere for 3 days).	Oxygen	181-183	snail family transcriptional repressor 1	Homo sapiens	14-20
24142693-7	2013	By contrast, ligand stimulation of non-overexpressed ERBB2 transiently removes UCP2 and paradoxically reduces the mitochondrial membrane potential, oxygen consumption, and OXPHOS on a signaling time scale.	Oxygen	148-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-58
24152727-5	2013	In oxygen reversal experiments (i.e., when PCN cells were exposed to SCN for 24 h and vice versa), we found that preexposure to 21% O2 decreased the migratory ability, but not the proliferative ability, of the PCN-HUAECs in response to FGF2 and VEGFA.	Oxygen	132-134	fibroblast growth factor 2	Homo sapiens	236-240
24152727-5	2013	In oxygen reversal experiments (i.e., when PCN cells were exposed to SCN for 24 h and vice versa), we found that preexposure to 21% O2 decreased the migratory ability, but not the proliferative ability, of the PCN-HUAECs in response to FGF2 and VEGFA.	Oxygen	132-134	vascular endothelial growth factor A	Homo sapiens	245-250
24228842-0	2013	"Criss-crossed" dinucleating behavior of an N4 Schiff base ligand: formation of a mu-OH,mu-O2 dicobalt(III) core via O2 activation.	Oxygen	91-93	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	103-106
24089376-0	2013	Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.	Oxygen	52-54	insulin	Homo sapiens	37-44
24089376-2	2013	It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release.	Oxygen	101-103	insulin	Homo sapiens	40-47
24089376-2	2013	It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release.	Oxygen	101-103	insulin	Homo sapiens	69-76
24089376-4	2013	Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain low O2-induced ATP release from human erythrocytes.	Oxygen	100-102	insulin	Homo sapiens	41-50
24089376-4	2013	Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain low O2-induced ATP release from human erythrocytes.	Oxygen	100-102	insulin	Homo sapiens	55-62
24089376-5	2013	Using a thin-film tonometer to alter O2 tension, we determined that either C-peptide or insulin alone inhibits low O2-induced ATP release in a concentration-dependent manner; however, coadministration of the peptides at a 1:1 ratio does not (n = 5; P &lt; 0.05).	Oxygen	37-39	insulin	Homo sapiens	75-84
24089376-5	2013	Using a thin-film tonometer to alter O2 tension, we determined that either C-peptide or insulin alone inhibits low O2-induced ATP release in a concentration-dependent manner; however, coadministration of the peptides at a 1:1 ratio does not (n = 5; P &lt; 0.05).	Oxygen	115-117	insulin	Homo sapiens	75-84
24089376-5	2013	Using a thin-film tonometer to alter O2 tension, we determined that either C-peptide or insulin alone inhibits low O2-induced ATP release in a concentration-dependent manner; however, coadministration of the peptides at a 1:1 ratio does not (n = 5; P &lt; 0.05).	Oxygen	115-117	insulin	Homo sapiens	88-95
24089376-8	2013	However, at a concentration of insulin found in the peripheral circulation of humans under postprandial conditions (0.5 nM), a ratio of C-peptide to insulin of 6:1 inhibited low O2-induced ATP release (n = 5).	Oxygen	178-180	insulin	Homo sapiens	31-38
22703342-11	2013	INNOVATION: Reactive oxygen species (ROS)-induced hypoxic gene expression in normoxia involves the oxygen-responding Rox1 transcriptional machinery.	Oxygen	21-27	Rox1p	Saccharomyces cerevisiae S288C	117-121
24089376-8	2013	However, at a concentration of insulin found in the peripheral circulation of humans under postprandial conditions (0.5 nM), a ratio of C-peptide to insulin of 6:1 inhibited low O2-induced ATP release (n = 5).	Oxygen	178-180	insulin	Homo sapiens	136-145
24089376-8	2013	However, at a concentration of insulin found in the peripheral circulation of humans under postprandial conditions (0.5 nM), a ratio of C-peptide to insulin of 6:1 inhibited low O2-induced ATP release (n = 5).	Oxygen	178-180	insulin	Homo sapiens	149-156
23973738-3	2013	Chronoamperometry measurements showed a detection limit towards oxygen of 6 +- 1 muM with a linear range of 6-300 muM, i.e. exceeding usual physiological ranges of oxygen in human tissues and fluids.	Oxygen	64-70	latexin	Homo sapiens	81-84
23880643-6	2013	Of 71 proteins identified, five proteins involved in extracellular matrix (ECM) remodeling exhibited &gt;=2-fold decrease under low O2 culture and were confirmed by Western immunoblot and qRT-PCR: fibronectin 1, TGF-beta1-induced protein (betaig-h3), osteonectin, and collagens type 1alpha1 and alpha2.	Oxygen	132-134	fibronectin 1	Homo sapiens	197-210
23880643-6	2013	Of 71 proteins identified, five proteins involved in extracellular matrix (ECM) remodeling exhibited &gt;=2-fold decrease under low O2 culture and were confirmed by Western immunoblot and qRT-PCR: fibronectin 1, TGF-beta1-induced protein (betaig-h3), osteonectin, and collagens type 1alpha1 and alpha2.	Oxygen	132-134	transforming growth factor beta 1	Homo sapiens	212-221
23880643-9	2013	Fifteen cytokines/chemokines including Type 2 cytokines IL-13, MCP-1, and CD40 ligand were detected in ambient O2 ASC medium.	Oxygen	111-113	interleukin 13	Homo sapiens	56-61
23973738-3	2013	Chronoamperometry measurements showed a detection limit towards oxygen of 6 +- 1 muM with a linear range of 6-300 muM, i.e. exceeding usual physiological ranges of oxygen in human tissues and fluids.	Oxygen	64-70	latexin	Homo sapiens	114-117
23880643-10	2013	IL-6 was detected in low O2 but not ambient O2 ASC medium.	Oxygen	25-27	interleukin 6	Homo sapiens	0-4
23973738-3	2013	Chronoamperometry measurements showed a detection limit towards oxygen of 6 +- 1 muM with a linear range of 6-300 muM, i.e. exceeding usual physiological ranges of oxygen in human tissues and fluids.	Oxygen	164-170	latexin	Homo sapiens	81-84
23973738-3	2013	Chronoamperometry measurements showed a detection limit towards oxygen of 6 +- 1 muM with a linear range of 6-300 muM, i.e. exceeding usual physiological ranges of oxygen in human tissues and fluids.	Oxygen	164-170	latexin	Homo sapiens	114-117
24140851-8	2013	The higher heating value (HHV) and oxygen content of HSF from humin were fully compatible with biofuel characteristics.	Oxygen	35-41	interleukin 6	Homo sapiens	53-56
23846330-12	2013	Reduction of O2 (.-) generation results from reversal of eNOS uncoupling and inhibition of arginase and iNOS.	Oxygen	13-15	nitric oxide synthase 2	Homo sapiens	104-108
24177164-7	2013	PNP biodegradation was unstable and the oxygen limiting condition was found to be the main explanation for this unsteadiness.	Oxygen	40-46	purine nucleoside phosphorylase	Homo sapiens	0-3
24177164-8	2013	An increase in dissolved oxygen concentration from 2.0 to 4.5 mg O2 L(-1) significantly enhanced PNP removal, achieving total elimination.	Oxygen	25-31	purine nucleoside phosphorylase	Homo sapiens	97-100
23632742-3	2013	In the study, the expression of CAT, GPx, SOD1, and SOD2 and their activities in rat cardiomyocytes in infrasound exposure groups were significantly decreased compared to those in the various time controls, along with significantly higher levels of O2 (-) and H2O2.	Oxygen	249-251	catalase	Rattus norvegicus	32-35
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Oxygen	245-251	apolipoprotein A-I	Salmo salar	153-158
23634964-15	2013	A negative correlation exists between adiponectin and blood glucose levels and a positive correlation between adiponectin and oxygen saturation.	Oxygen	126-132	adiponectin, C1Q and collagen domain containing	Homo sapiens	110-121
23884959-2	2013	This study showed that pathological hypoxia (&lt;0.5% O2) increased the expression of androgen receptor (AR) target genes such as prostate-specific antigen (PSA) and kallikrein-related peptidase 2 in LNCaP human prostate cancer cells by modifying the quantity and activity of related Jumonji C domain-containing histone demethylases (JMJDs).	Oxygen	54-56	androgen receptor	Homo sapiens	86-103
23884959-2	2013	This study showed that pathological hypoxia (&lt;0.5% O2) increased the expression of androgen receptor (AR) target genes such as prostate-specific antigen (PSA) and kallikrein-related peptidase 2 in LNCaP human prostate cancer cells by modifying the quantity and activity of related Jumonji C domain-containing histone demethylases (JMJDs).	Oxygen	54-56	androgen receptor	Homo sapiens	105-107
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Oxygen	245-251	beta-2-microglobulin	Salmo salar	167-170
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Oxygen	245-251	glyceraldehyde-3-phosphate dehydrogenase	Salmo salar	189-194
24034856-4	2013	Like soluble guanylate cyclase, cytochrome c" also excludes O2 completely from the binding pocket.	Oxygen	60-62	cytochrome c, somatic	Homo sapiens	32-44
24338456-4	2013	PATIENTS AND METHODS: Two cases of complicated massive pulmonary gas embolism were presented: one in CRT and the other in pacemaker implantation, both of which were captured rapidly and treated successfully by inhalation of high flow oxygen, closure of gas inflow tract, position change, and vasoactive drugs.	Oxygen	234-240	calcitonin receptor	Homo sapiens	101-104
24080119-3	2013	We report that peroxidase and H2O2 induce superoxide dismutase (SOD)-sensitive, L-012-derived CL in the presence of oxygen.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	42-62
24080119-3	2013	We report that peroxidase and H2O2 induce superoxide dismutase (SOD)-sensitive, L-012-derived CL in the presence of oxygen.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	64-67
24080119-5	2013	Self-generated O2(*-) during oxidation of L-012 and luminol analogs artifactually induce CL inhibitable by SOD.	Oxygen	15-17	superoxide dismutase 1	Homo sapiens	107-110
23689986-0	2013	Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-105
23952610-1	2013	The mammalian target of rapamycin (mTOR) pathway is an important integrator of nutrient-sensing signals in all mammalian cells, and acts to coordinate the cell proliferation with the availability of nutrients such as glucose, amino acids and energy (oxygen and ATP).	Oxygen	250-256	mechanistic target of rapamycin kinase	Homo sapiens	4-33
23952610-1	2013	The mammalian target of rapamycin (mTOR) pathway is an important integrator of nutrient-sensing signals in all mammalian cells, and acts to coordinate the cell proliferation with the availability of nutrients such as glucose, amino acids and energy (oxygen and ATP).	Oxygen	250-256	mechanistic target of rapamycin kinase	Homo sapiens	35-39
24045779-0	2013	Vascular endothelial growth factor and angiopoietin production by primate follicles during culture is a function of growth rate, gonadotrophin exposure and oxygen milieu.	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	0-34
23670361-1	2013	The increase in oxygen uptake &gt; 100 ml   min-1 during steady state exercise when elevating the inspired fractional air content (FinO2) from 0.21-1.00 defines the "spirografic oxygen deficit" (SOD).	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
23670361-1	2013	The increase in oxygen uptake &gt; 100 ml   min-1 during steady state exercise when elevating the inspired fractional air content (FinO2) from 0.21-1.00 defines the "spirografic oxygen deficit" (SOD).	Oxygen	16-22	superoxide dismutase 1	Homo sapiens	165-199
23804301-4	2013	We have determined that YB-1 is a substrate for the protein-crosslinking enzyme transglutaminase 2 (TG2) that catalyzes calcium-dependent formation of covalent gamma-glutamyl-isopeptide linkages in response to reactive oxygen signaling.	Oxygen	219-225	Y-box binding protein 1	Homo sapiens	24-28
23804301-4	2013	We have determined that YB-1 is a substrate for the protein-crosslinking enzyme transglutaminase 2 (TG2) that catalyzes calcium-dependent formation of covalent gamma-glutamyl-isopeptide linkages in response to reactive oxygen signaling.	Oxygen	219-225	transglutaminase 2	Homo sapiens	80-98
23804301-4	2013	We have determined that YB-1 is a substrate for the protein-crosslinking enzyme transglutaminase 2 (TG2) that catalyzes calcium-dependent formation of covalent gamma-glutamyl-isopeptide linkages in response to reactive oxygen signaling.	Oxygen	219-225	transglutaminase 2	Homo sapiens	100-103
23804301-7	2013	In human pulmonary fibroblasts, YB-1 crosslinking was inhibited by (a) anti-oxidant cystamine, (b) the reactive-oxygen antagonist, diphenyleneiodonium, (c) competitive inhibition of TG2 transamidation using the aminyl-surrogate substrate, monodansylcadaverine, and (d) transfection with small-interfering RNA specific for human TG2 mRNA.	Oxygen	112-118	Y-box binding protein 1	Homo sapiens	32-36
23689986-2	2013	PROCEDURES: We synthesized the peptide probes that contain or lack an essential sequence of the oxygen-dependent degradation of HIF-1alpha in proteasomes ((123/125)I-DKOP30 or (125)I-mDKOP, respectively).	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
24132642-1	2013	Hypoxia-inducible factor 1 (HIF-1) is regulated by the oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHDs).	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24132642-1	2013	Hypoxia-inducible factor 1 (HIF-1) is regulated by the oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHDs).	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
24195787-1	2013	Myoglobin (Mb) binds diatomic ligands, like O2, CO, and NO, in a cavity that is only transiently accessible.	Oxygen	44-46	myoglobin	Equus caballus	0-9
24091996-7	2013	In a concentration of 10 muM, 8-hydroxy-efavirenz and efavirenz did not affect mitochondrial respiration, while both compounds lowered in a concentration of 60 muM significantly the oxygen consumption by mitochondria that had been isolated form cultured astrocytes, suggesting that the stimulation of glycolytic flux by 8-hydroxy-efavrienz is not caused by direct inhibition of respiration.	Oxygen	182-188	latexin	Homo sapiens	160-163
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	84-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-25
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	84-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	215-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-25
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	215-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	215-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-25
24349900-7	2013	Expression of HIF- 1alpha protein and the HIF-1-downstream genes were low under 20% O2 conditions and increased in response to PGE1 treatment in both HUVECs and HASMCs in a dose- and time-dependent manner under 20% O2 conditions as comparable to exposure to 1% O2 conditions.	Oxygen	215-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
24187992-5	2013	Upon investigation of the derivatives with L = PPh3, AsPh3, Me2S O, and (H2N)2C S, it has been concluded that an electrostatic interaction between the oxygen lone pair of the iminoether and the platinum center, fostered by the net positive charge of the complex and the low dielectric constant around the metal core provided by the hydrophobic L ligands, stabilizes the Z configuration.	Oxygen	151-157	caveolin 1	Homo sapiens	47-51
24104860-1	2013	An oxygen generation core-shell structure uploading rose bengal has been fabricated by covalent assembly of catalase and alginate dialdehyde via Schiff"s base.	Oxygen	3-9	catalase	Homo sapiens	108-116
24324479-7	2013	However, in senescence, superoxide dismutase (SOD), that converts superoxide anion radical ([Formula: see text]) to hydrogen peroxide (H2O2,) decreases, while the thylakoid Ndh complex, that favors the generation of singlet oxygen ((1)O2) and [Formula: see text], and peroxidase (PX), that consumes H2O2, increase.	Oxygen	137-139	superoxide dismutase 1	Homo sapiens	24-44
24324479-7	2013	However, in senescence, superoxide dismutase (SOD), that converts superoxide anion radical ([Formula: see text]) to hydrogen peroxide (H2O2,) decreases, while the thylakoid Ndh complex, that favors the generation of singlet oxygen ((1)O2) and [Formula: see text], and peroxidase (PX), that consumes H2O2, increase.	Oxygen	137-139	superoxide dismutase 1	Homo sapiens	46-49
24312167-4	2013	Based on a joint analysis of hemoglobin structures in the Protein Data Bank (Ren, companion article), here I present a reverse engineering approach to elucidate how two subunits within each dimer reciprocate identical motions that achieves intradimer cooperativity, how ligand-induced structural signals from two subunits are integrated to drive quaternary rotation, and how the structural environment at the oxygen binding sites alter their binding affinity.	Oxygen	409-415	renin	Homo sapiens	77-80
24278276-4	2013	Exposure to low oxygen tension stimulated ROS accumulation and increased apoptosis in CMECs within 6-24 h. Hypoxia also significantly increased the expressions of HIF-1alpha and FoxO3a.	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	163-173
24278276-4	2013	Exposure to low oxygen tension stimulated ROS accumulation and increased apoptosis in CMECs within 6-24 h. Hypoxia also significantly increased the expressions of HIF-1alpha and FoxO3a.	Oxygen	16-22	forkhead box O3	Homo sapiens	178-184
24260556-2	2013	sFlt-1, a truncated and soluble form of VEGFR-1 which binds and inhibits VEGF, is increased in preeclampsia and is positively regulated by low oxygen.	Oxygen	143-149	fms related receptor tyrosine kinase 1	Homo sapiens	40-47
24260556-2	2013	sFlt-1, a truncated and soluble form of VEGFR-1 which binds and inhibits VEGF, is increased in preeclampsia and is positively regulated by low oxygen.	Oxygen	143-149	vascular endothelial growth factor A	Homo sapiens	40-44
23988122-2	2013	The series was derived from a known AR binder, which had previously been shown to form a halogen bond between its bromine atom and the oxygen atom of the Thr-113 side chain of AR.	Oxygen	135-141	aldo-keto reductase family 1 member B	Homo sapiens	36-38
23988122-2	2013	The series was derived from a known AR binder, which had previously been shown to form a halogen bond between its bromine atom and the oxygen atom of the Thr-113 side chain of AR.	Oxygen	135-141	aldo-keto reductase family 1 member B	Homo sapiens	176-178
24233717-1	2013	Cytochrome P450 enzymes activate oxygen at heme iron centers to oxidize relatively inert substrate carbon-hydrogen bonds.	Oxygen	33-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
23770394-5	2013	Pre-incubation of the mAb-covered electrode with native Abeta decreased the amount of Abeta(1-16)-heme-AuNPs immobilized onto the electrode, resulting in the decrease of the reduction current of O2 to H2O2.	Oxygen	195-197	amyloid beta precursor protein	Homo sapiens	56-61
24236174-4	2013	CD4 lymphocyte apoptotic and autophagic responses to hypoxic exercise (HE, 100 W under 12%O2 for 30 minutes) were determined before and after various regimens.	Oxygen	90-92	CD4 molecule	Homo sapiens	0-3
24252187-1	2013	BACKGROUND: The Blood-brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Abeta) peptides.	Oxygen	69-75	amyloid beta precursor protein	Homo sapiens	146-166
24236104-9	2013	Furthermore, CBS also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial ROS production, oxygen consumption and ATP generation.	Oxygen	114-120	cystathionine beta-synthase	Homo sapiens	13-16
23880069-1	2013	BACKGROUND: Oxygen sensing in mammalian cells is a conserved signaling pathway regulated by hypoxia inducible factor type 1 (HIF-1).	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-123
24062309-6	2013	Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8.	Oxygen	21-27	interleukin 6	Homo sapiens	115-119
24062309-6	2013	Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8.	Oxygen	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
24117377-4	2013	CYP on polycrystalline ITO film enhanced the electron transfer rate of oxygen reduction about fifteen times more than with amorphous film.	Oxygen	71-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
24117377-6	2013	The oxygen reduction current at the polycrystalline ITO film electrodes had increased 3- to 4-fold, specifically coupled with the oxidation of drugs (testosterone and quinidine) by the monooxygenase activity of CYP.	Oxygen	4-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	211-214
24117377-7	2013	In contrast, the oxygen reduction current completely disappeared in the presence of the CYP inhibitor (ketoconazole).	Oxygen	17-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	88-91
23986517-8	2013	Ouabain-sensitive oxygen consumption was 17 +- 5% (P &lt; 0.043) greater in tubules from ANG II-treated than vehicle rats.	Oxygen	18-24	angiotensinogen	Rattus norvegicus	89-95
23880069-1	2013	BACKGROUND: Oxygen sensing in mammalian cells is a conserved signaling pathway regulated by hypoxia inducible factor type 1 (HIF-1).	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-130
24229686-0	2013	Cbl-b and PI3K/Akt pathway are differently involved in oxygen-glucose deprivation preconditioning in PC12 cells.	Oxygen	55-61	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
24096875-8	2013	Understanding this novel oxygen-p53 survival pathway will open new avenues in cardioprotection molecular therapy.	Oxygen	25-31	tumor protein p53	Homo sapiens	32-35
23884884-12	2013	In summary, a decrease in ATP7A protein expression contributes to impaired SOD3 activity, resulting in O2( -) overproduction and endothelial dysfunction in blood vessels of T1DM.	Oxygen	103-105	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	26-31
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Oxygen	46-52	tumor protein p53	Homo sapiens	0-3
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Oxygen	46-52	tumor protein p53	Homo sapiens	95-98
23884884-10	2013	Furthermore, SOD3-deficient T1DM mice or ATP7A mutant T1DM mice augment endothelial dysfunction and vascular O2( -) production versus T1DM mice.	Oxygen	109-111	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	41-46
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Oxygen	46-52	nitric oxide synthase 3	Homo sapiens	102-106
23952904-0	2013	Post-translational regulation of gene expression using the ATF4 oxygen-dependent degradation domain for hypoxia-specific gene therapy.	Oxygen	64-70	activating transcription factor 4	Mus musculus	59-63
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Oxygen	46-52	tumor protein p53	Homo sapiens	95-98
24096875-4	2013	p53 exhibited a differential DNA-binding, namely, BAX-p53RE in the infarct heart or NOS3-p53RE in the oxygenated heart, which was regulated by oxygen-induced, post-translational modification of p53.	Oxygen	102-108	tumor protein p53	Homo sapiens	0-3
24096875-4	2013	p53 exhibited a differential DNA-binding, namely, BAX-p53RE in the infarct heart or NOS3-p53RE in the oxygenated heart, which was regulated by oxygen-induced, post-translational modification of p53.	Oxygen	102-108	nitric oxide synthase 3	Homo sapiens	84-88
24096875-5	2013	In the infarct heart, p53 was heavily acetylated at Lys(118) residue, which was exclusively reversed in the oxygenated heart, apparently regulated by oxygen-dependent expression of TIP60.	Oxygen	108-114	tumor protein p53	Homo sapiens	22-25
23952904-3	2013	In this study, the oxygen-dependent degradation (ODD) domain on activating transcription factor-4 (ATF4) was evaluated for post-translational regulation of proteins.	Oxygen	19-25	activating transcription factor 4	Mus musculus	64-97
23952904-3	2013	In this study, the oxygen-dependent degradation (ODD) domain on activating transcription factor-4 (ATF4) was evaluated for post-translational regulation of proteins.	Oxygen	19-25	activating transcription factor 4	Mus musculus	99-103
23999071-8	2013	Reoxygenation with 100% oxygen after hypoxia uniquely upregulated Gadd45g, Dusp1, Peg3, and Tgm2.	Oxygen	2-8	paternally expressed 3	Mus musculus	82-86
23792783-7	2013	Oxygen deprivation increased the expression of inducible nitric oxide synthetase (iNOS) and up-regulated selected cytokines and chemokines.	Oxygen	0-6	nitric oxide synthase 2, inducible	Mus musculus	82-86
23462909-2	2013	The role of human beta defensin-1 (hBD-1) is notable because its gene (beta-defensin 1 (DEFB1)) is constitutively expressed and its antimicrobial activity is potentiated in the low-oxygen environment that characterizes the intestinal mucosa.	Oxygen	181-187	defensin beta 1	Homo sapiens	18-33
23462909-2	2013	The role of human beta defensin-1 (hBD-1) is notable because its gene (beta-defensin 1 (DEFB1)) is constitutively expressed and its antimicrobial activity is potentiated in the low-oxygen environment that characterizes the intestinal mucosa.	Oxygen	181-187	defensin beta 1	Homo sapiens	35-40
23462909-2	2013	The role of human beta defensin-1 (hBD-1) is notable because its gene (beta-defensin 1 (DEFB1)) is constitutively expressed and its antimicrobial activity is potentiated in the low-oxygen environment that characterizes the intestinal mucosa.	Oxygen	181-187	defensin beta 1	Homo sapiens	71-86
23462909-2	2013	The role of human beta defensin-1 (hBD-1) is notable because its gene (beta-defensin 1 (DEFB1)) is constitutively expressed and its antimicrobial activity is potentiated in the low-oxygen environment that characterizes the intestinal mucosa.	Oxygen	181-187	defensin beta 1	Homo sapiens	88-93
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	Oxygen	21-23	interleukin 1 beta	Homo sapiens	80-88
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	Oxygen	44-46	interleukin 1 beta	Homo sapiens	80-88
23850530-6	2013	Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at &lt;1% O2.	Oxygen	130-132	interleukin 1 beta	Homo sapiens	13-21
23668629-5	2013	In the present study, we investigated the impact of spheroid size on hypoxia-inducible transcription factor (HIF)-1 activity in spheroid cultures under atmospheric and physiological oxygen conditions using a fluorescent marker.	Oxygen	182-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-115
24055807-5	2013	In mice permitted to spontaneously exercise on a running-wheel, GALP ICV administration increased the consumed oxygen volume and heat production level from 5 to 11h after administration.	Oxygen	111-117	galanin-like peptide	Mus musculus	64-68
23668629-6	2013	Hypoxia could be induced and modulated by controlling the size of the spheroid; HIF-1 activity increased with spheroid size and with decreasing external oxygen concentration.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
24286132-0	2013	Low oxygen tension increased fibronectin fragment induced catabolic activities--response prevented with biomechanical signals.	Oxygen	4-10	fibronectin 1	Homo sapiens	29-40
23767827-5	2013	Since PPARgamma is known to be regulated by hypoxia in adipose tissue, we hypothesized that there may be a link between oxygen tension, PPARgamma expression, and trophoblast differentiation.	Oxygen	120-126	peroxisome proliferator activated receptor gamma	Homo sapiens	6-15
24030640-1	2013	Formation of the NO3 radical was observed following photolysis of the CH2I2 + O2 system at 248 nm under ambient atmospheric boundary layer conditions (~760 Torr and 297 K) in the presence of NO2.	Oxygen	78-80	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
24286132-10	2013	Whilst FN-f reduced GAG synthesis at all oxygen tension, the effect of IL-1beta was significant at 1% oxygen tension.	Oxygen	102-108	interleukin 1 beta	Homo sapiens	71-79
24286132-12	2013	In unstrained constructs, FN-f was more effective than IL-1beta at 5% oxygen tension and increased production of NO, PGE2, MMP, IL-1beta, IL-6 and TNFalpha.	Oxygen	70-76	interleukin 1 beta	Homo sapiens	55-63
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Oxygen	127-133	interleukin 1 beta	Homo sapiens	75-83
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Oxygen	127-133	nitric oxide synthase 2	Homo sapiens	146-150
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Oxygen	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
24000351-1	2013	The reaction site of the Co(II) porphyrin created by an amide group and coordinating 1,2-dimethylimidazole at the fifth site activated an O2 molecule, and then hydroxylated the meso-carbon of the ligand.	Oxygen	138-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
24144230-6	2013	CONCLUSIONS: We observe that transformations which increased polarity (for example adding an oxygen, or an sp2 nitrogen), decreased lipophilicity (removing carbons), or decreased positive charge consistently reduced hERG inhibition between 3- and 10-fold.	Oxygen	93-99	ETS transcription factor ERG	Homo sapiens	216-220
24038300-0	2013	Synthesis, characterization, and reactivity of cobalt(III)-oxygen complexes bearing a macrocyclic N-tetramethylated cyclam ligand.	Oxygen	59-65	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	54-57
23959856-3	2013	HIF-1 activity is usually suppressed under normoxic conditions because of rapid oxygen-dependent degradation of HIF-1alpha.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
23959856-3	2013	HIF-1 activity is usually suppressed under normoxic conditions because of rapid oxygen-dependent degradation of HIF-1alpha.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
24038300-2	2013	In this work, a side-on cobalt(III)-peroxo complex bearing a macrocyclic N-tetramethylated cyclam (TMC) ligand, [Co(III) (15-TMC)(O2 )](+) , was synthesized and characterized with various spectroscopic methods.	Oxygen	130-134	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-34
24038300-2	2013	In this work, a side-on cobalt(III)-peroxo complex bearing a macrocyclic N-tetramethylated cyclam (TMC) ligand, [Co(III) (15-TMC)(O2 )](+) , was synthesized and characterized with various spectroscopic methods.	Oxygen	130-134	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	113-120
24020639-4	2013	Rate enhancements up to 113 and 48% were observed, yielding a maximum oxygen flux of 0.32 and 4.53 mL min(-1) cm(-2) under air/helium and air/CO gradients at 950  C, respectively.	Oxygen	70-76	CD59 molecule (CD59 blood group)	Homo sapiens	102-108
24116217-9	2013	Together, these results demonstrate that loss of Icp55p function reduces mitochondrial oxygen consumption and ATP synthase complex assembly in glucose media, while also promoting stress resistance, decreasing reactive oxygen species and increasing chronological lifespan through mechanisms that are distinct from decreased Tor1p activity.	Oxygen	87-93	aminopeptidase	Saccharomyces cerevisiae S288C	49-55
24050193-0	2013	Mechanistic studies on the reaction of nitroxylcobalamin with dioxygen: evidence for formation of a peroxynitritocob(III)alamin intermediate.	Oxygen	62-70	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	117-120
24050193-4	2013	Only base-on NOCbl reacts with O2, and the reaction proceeds via an associative mechanism involving a peroxynitritocob(III)alamin intermediate, Co(III)-N(O)OO(-).	Oxygen	31-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	119-122
23885061-9	2013	I propose that such gene duplications were the result of shear stress on the microvasculature, locally generating radical oxygen species that caused DNA mutations, giving rise to duplication of the PTHrP and beta-adrenergic receptor genes.	Oxygen	122-128	parathyroid hormone-like peptide	Mus musculus	198-203
23001818-2	2013	Treatment with the p38 MAP kinase inhibitor SB203580 increased both lifespan and growth rate, as did reduction of oxidative stress using low oxygen in some strains.	Oxygen	141-147	mitogen-activated protein kinase 14	Homo sapiens	19-22
23919773-3	2013	BACE1 levels are increased under low energy or low oxygen conditions, which may occur in individuals with impaired circulation in the brain.	Oxygen	51-57	beta-secretase 1	Homo sapiens	0-5
23643711-4	2013	Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1alpha transcription and low content of phosphorylated CREB.	Oxygen	45-51	PPARG coactivator 1 alpha	Homo sapiens	136-145
23902163-4	2013	When tested with a 50-ml reservoir, a high fractional oxygen concentration was achieved: mean (SD) 0.83 (0.11) at a flow of 15 l.min(-1) oxygen.	Oxygen	54-60	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
23902163-4	2013	When tested with a 50-ml reservoir, a high fractional oxygen concentration was achieved: mean (SD) 0.83 (0.11) at a flow of 15 l.min(-1) oxygen.	Oxygen	137-143	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
24120591-2	2013	The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis.	Oxygen	142-148	erythropoietin	Homo sapiens	4-18
23832611-5	2013	An ex1/ex2/flu mutant accumulates in the dark Pchlide and upon illumination generates similar amounts of (1)O2 as flu, but (1)O2-mediated responses are abrogated in the triple mutant.	Oxygen	105-110	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	3-6
24059558-11	2013	S100B storage in cardiomyocytes correlates with the different oxygen concentration used during reoxygenation, being higher in piglets reoxygenated with 18% and 21%, and lower in animals reoxygenated with 40% oxygen.	Oxygen	62-68	protein S100-B	Sus scrofa	0-5
24059558-11	2013	S100B storage in cardiomyocytes correlates with the different oxygen concentration used during reoxygenation, being higher in piglets reoxygenated with 18% and 21%, and lower in animals reoxygenated with 40% oxygen.	Oxygen	97-103	protein S100-B	Sus scrofa	0-5
24059558-12	2013	Intermediate levels of S100B expression were found in 100% O2-treated animals.	Oxygen	59-61	protein S100-B	Sus scrofa	23-28
23486514-8	2013	Erythropoietin (EPO) is critical for the development of erythroid progenitors and thus for tissue oxygen supply.	Oxygen	98-104	erythropoietin	Homo sapiens	0-14
23486514-8	2013	Erythropoietin (EPO) is critical for the development of erythroid progenitors and thus for tissue oxygen supply.	Oxygen	98-104	erythropoietin	Homo sapiens	16-19
23881110-7	2013	The ratio of PC to PG in BAL-relevant for surfactant dysfunction-was significantly elevated by oxygen exposure, with the greatest increase in Abca3(+/-) mice.	Oxygen	95-101	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	142-147
23670359-11	2013	The s-EPO rise, 24 h after resurfacing, is clearly documented and related to the "Normobaric Oxygen Paradox".	Oxygen	93-99	erythropoietin	Homo sapiens	6-9
23670359-12	2013	This evidence suggests interesting hypotheses for new clinical applications such as modulation of s-EPO production and Hgb content triggered by appropriate O2 administration in pre-surgical patients or in some anemic disease.	Oxygen	156-158	erythropoietin	Homo sapiens	100-103
23959272-0	2013	Binding of V(IV)O2+ to the Fe binding sites of human serum transferrin.	Oxygen	16-19	transferrin	Homo sapiens	59-70
23959272-2	2013	The binding of V(IV)O2+ to human serum transferrin (hTF) at the FeIII binding sites is addressed.	Oxygen	20-23	transferrin	Homo sapiens	39-50
23924606-6	2013	Our RT-PCR and immunoblotting results indicated that csOATP1B3, but not WT OATP1B3, can be induced in response to ambient or chemical hypoxia (upon exposure to 1% O2 or cobalt chloride).	Oxygen	163-165	solute carrier organic anion transporter family member 1B3	Homo sapiens	55-62
23856923-2	2013	We have recently shown that a low-dose vasopressin infusion (0.005 - 0.01 units/kg per hour) may improve myocardial oxygen transport balance in a swine model of neonatal hypoxia-reoxygenation.	Oxygen	116-122	vasopressin	Sus scrofa	39-50
24069415-0	2013	c-Src and neural Wiskott-Aldrich syndrome protein (N-WASP) promote low oxygen-induced accelerated brain invasion by gliomas.	Oxygen	71-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
24069415-6	2013	However, only Src-mediated NWASP phosphorylation distinguishes the four cell lines that exhibit enhanced motility in low ambient oxygen.	Oxygen	129-135	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-17
24069415-7	2013	Downregulating c-Src or NWASP by RNA interference abrogates the low-oxygen-induced enhancement in motility by in vitro assays and in organotypic brain slice cultures.	Oxygen	68-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-20
24069415-8	2013	The findings support the idea that c-Src and NWASP play key roles in mediating the molecular pathogenesis of low oxygen-induced accelerated brain invasion by gliomas.	Oxygen	113-119	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
23886708-1	2013	Hypoxia inducible factor 1alpha (HIF-1alpha) regulates oxygen homeostasis in the cell through a sensing mechanism involving its hydroxylation and binding to the von Hippel-Lindau (VHL) tumor suppressor.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23886708-1	2013	Hypoxia inducible factor 1alpha (HIF-1alpha) regulates oxygen homeostasis in the cell through a sensing mechanism involving its hydroxylation and binding to the von Hippel-Lindau (VHL) tumor suppressor.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23977830-1	2013	S-Glutathionylation is a redox-regulated modification that uncouples endothelial nitric oxide synthase (eNOS), switching its function from nitric oxide (NO) synthesis to ( )O2(-) generation, and serves to regulate vascular function.	Oxygen	173-175	nitric oxide synthase 3	Homo sapiens	104-108
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	Oxygen	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23833310-4	2013	RESULTS: LDH-A knockdown cells (KD9) showed a significant reduction in LDH-A protein and LDH activity, less acid production, decreased transwell migration and invasion, lower proliferation, reduced glucose consumption and glycolysis, and increase in oxygen consumption, reactive oxygen species (ROS), and cellular ATP levels, compared with control (NC) cells cultured in 25 mmol/L glucose.	Oxygen	250-256	lactate dehydrogenase A	Homo sapiens	9-14
23833310-4	2013	RESULTS: LDH-A knockdown cells (KD9) showed a significant reduction in LDH-A protein and LDH activity, less acid production, decreased transwell migration and invasion, lower proliferation, reduced glucose consumption and glycolysis, and increase in oxygen consumption, reactive oxygen species (ROS), and cellular ATP levels, compared with control (NC) cells cultured in 25 mmol/L glucose.	Oxygen	250-256	lactate dehydrogenase A	Homo sapiens	9-12
24030400-12	2013	Furthermore, microglial upregulation of TLR-4 occurred after oxygen and glucose deprivation, and the absence of functional TLR-4 significantly attenuated the production of proinflammatory cytokines.	Oxygen	61-67	toll-like receptor 4	Mus musculus	40-45
23919400-1	2013	The metalloenzyme Cu/Zn-superoxide dismutase (SOD1) catalyzes the reduction of superoxide anions into molecular oxygen and hydrogen peroxide.	Oxygen	112-118	superoxide dismutase 1	Homo sapiens	18-44
23919400-1	2013	The metalloenzyme Cu/Zn-superoxide dismutase (SOD1) catalyzes the reduction of superoxide anions into molecular oxygen and hydrogen peroxide.	Oxygen	112-118	superoxide dismutase 1	Homo sapiens	46-50
23085754-6	2013	Here, we show that even less severe hypoxia (0.1% O2) also induces activation of ATR through replicative stress.	Oxygen	50-52	ATR serine/threonine kinase	Homo sapiens	81-84
23927036-2	2013	To remove ROS, cells have developed ROS-specific defense mechanisms, including the enzyme Cu/Zn superoxide dismutase (SOD1), which catalyzes the disproportionation of superoxide anions into molecular oxygen and hydrogen peroxide.	Oxygen	200-206	superoxide dismutase 1	Homo sapiens	118-122
24040163-12	2013	1% O2 induced F-actin reorganization, increase of Hif-1alpha, vimentin and alpha-SMA in HSC-T6 cells.	Oxygen	3-5	actin alpha 2, smooth muscle, aorta	Mus musculus	75-84
23941465-1	2013	4-Hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate synthase (HMS) are similar enzymes that catalyze complex dioxygenation reactions using the substrates 4-hydroxyphenylpyruvate (HPP) and dioxygen.	Oxygen	24-32	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	37-41
23900840-6	2013	These results suggest that O2 concentration gradients influence the formation of Wnt ligand gradients, which are involved in the regulation of pluripotency, cell proliferation, and cell differentiation.	Oxygen	27-29	Wnt family member 1	Homo sapiens	81-84
23919805-3	2013	In deareated buffered solutions the open circuit potential of the PdH in equilibrium between its beta and alpha phases (OCP(beta alpha)) does not depend on the tip-substrate distance while in aerated conditions it is found to be controlled by hindered diffusion of oxygen.	Oxygen	265-271	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	66-69
23919805-7	2013	Over a wide potential window, the highly reactive nanostructure promotes the reduction of oxygen which rapidly discharges hydrogen from the PdH.	Oxygen	90-96	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	140-143
23864660-1	2013	3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is a dimeric flavoprotein that catalyzes the NADH- and oxygen-dependent para-hydroxylation of 3-hydroxybenzoate to 2,5-dihydroxybenzoate.	Oxygen	124-130	3-hydroxybenzoate 6-hydroxylase	Rhodococcus jostii RHA1	0-38
23942974-0	2013	Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].	Oxygen	77-83	activating transcription factor 4	Mus musculus	54-58
23711352-0	2013	Identification of multiple, oxygen-stable HIF1 alpha isoforms, and augmented expression of adrenomedullin in rheumatoid arthritis.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
23942974-3	2013	Therefore, the objective of this study was to determine whether ATF4 deficiency could reduce neovascularization in mice with oxygen-induced retinopathy (OIR).	Oxygen	125-131	activating transcription factor 4	Mus musculus	64-68
23811199-0	2013	Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations.	Oxygen	72-78	superoxide dismutase 1, soluble	Mus musculus	26-30
23811199-3	2013	We attempted to elucidate the molecular mechanisms responsible for the oxygen toxicity in SOD1-KO MEFs.	Oxygen	71-77	superoxide dismutase 1, soluble	Mus musculus	90-94
24744487-6	2013	Maximum oxygen uptake increased from 60.0 +- 1.5 ml min(-1) kg(-1) at the beginning of the season to 65.2 +- 1.4 ml min(-1) kg(-1) (P &lt; 0.05) in the season.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	52-58
24744487-6	2013	Maximum oxygen uptake increased from 60.0 +- 1.5 ml min(-1) kg(-1) at the beginning of the season to 65.2 +- 1.4 ml min(-1) kg(-1) (P &lt; 0.05) in the season.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
23785078-3	2013	We therefore sought to investigate the effects of acute (1 day) and more sustained (7 days) hypoxia (13% O2) on the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) and its targets in mouse cardiac and skeletal muscle.	Oxygen	105-107	peroxisome proliferator activated receptor alpha	Mus musculus	137-185
23785078-3	2013	We therefore sought to investigate the effects of acute (1 day) and more sustained (7 days) hypoxia (13% O2) on the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) and its targets in mouse cardiac and skeletal muscle.	Oxygen	105-107	peroxisome proliferator activated receptor alpha	Mus musculus	187-196
23684916-11	2013	Data suggest that TNF-alpha-induced BAFF expression and BAFF-mediated VEGF expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments.	Oxygen	217-223	tumor necrosis factor	Homo sapiens	18-27
23806974-10	2013	These data demonstrate that decreased oxygen utilization in older age could have resulted in decreased mitochondrial ROS-mediated oxidative damage requiring less Sod2 for protection against mitochondrial oxidative stress in older wildtype or older Sod2(+/-) mice.	Oxygen	38-44	superoxide dismutase 2, mitochondrial	Mus musculus	162-166
23806974-10	2013	These data demonstrate that decreased oxygen utilization in older age could have resulted in decreased mitochondrial ROS-mediated oxidative damage requiring less Sod2 for protection against mitochondrial oxidative stress in older wildtype or older Sod2(+/-) mice.	Oxygen	38-44	superoxide dismutase 2, mitochondrial	Mus musculus	248-252
23999440-2	2013	This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance oxygen supply and demand.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
23788576-6	2013	Rox was higher at LT in T [22.7 +- 2.9, 75% peak oxygen consumption (Vo2peak)] compared with UT (13.4 +- 2.5, 68% Vo2peak, P &lt; 0.05).	Oxygen	49-55	MAX network transcriptional repressor	Homo sapiens	0-3
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Oxygen	220-226	egl-9 family hypoxia inducible factor 1	Homo sapiens	28-32
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Oxygen	220-226	hypoxia inducible factor 1 subunit alpha	Homo sapiens	304-314
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Oxygen	85-91	egl-9 family hypoxia inducible factor 1	Homo sapiens	28-32
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	304-314
23687307-3	2013	The effects of HDL or apoA-I, its major apolipoprotein, occur through the modulation of intracellular calcium, oxygen-derived free-radical production, numerous kinases, and enzymes, including endothelial nitric-oxide synthase (eNOS).	Oxygen	111-117	apolipoprotein A1	Homo sapiens	22-28
23815140-7	2013	Phosphorylation of IGF-I receptor by IGF-I was attenuated in low oxygen conditions.	Oxygen	65-71	insulin like growth factor 1	Homo sapiens	19-24
23815140-11	2013	These findings indicate that low oxygen conditions inhibit IGF-I action by increasing IGFBP-1, especially phosphorylated IGFBP-1, which inhibits IGF-I action.	Oxygen	33-39	insulin like growth factor 1	Homo sapiens	145-150
23815140-8	2013	IGF-I-induced phosphorylation of insulin receptor substrate-1 (IRS-1) was attenuated in low oxygen conditions as well.	Oxygen	92-98	insulin like growth factor 1	Homo sapiens	0-5
23815140-10	2013	While IGF-I-induced cell proliferation was also inhibited in low oxygen conditions, LR3IGF-I-stimulated cell proliferation was not inhibited.	Oxygen	65-71	insulin like growth factor 1	Homo sapiens	6-11
23815140-11	2013	These findings indicate that low oxygen conditions inhibit IGF-I action by increasing IGFBP-1, especially phosphorylated IGFBP-1, which inhibits IGF-I action.	Oxygen	33-39	insulin like growth factor 1	Homo sapiens	59-64
23423463-6	2013	In a model of the blood-brain barrier with human umbilical vascular epithelium cells, we found that t-PA in low concentrations prevented the impairment of the blood-brain barrier as a result of oxygen and glucose deprivation.	Oxygen	194-200	plasminogen activator, tissue type	Homo sapiens	100-104
23900639-3	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a nuclear transcription factor that facilitates the adaptation of human cells to compromised oxygen tension under hypoxic conditions.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23900639-3	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a nuclear transcription factor that facilitates the adaptation of human cells to compromised oxygen tension under hypoxic conditions.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23088526-1	2013	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha), the alpha subunit of the heterodimeric transcription factor HIF-1, maintains oxygen homeostasis by regulating gene expression.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
23088526-1	2013	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha), the alpha subunit of the heterodimeric transcription factor HIF-1, maintains oxygen homeostasis by regulating gene expression.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
23088526-1	2013	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha), the alpha subunit of the heterodimeric transcription factor HIF-1, maintains oxygen homeostasis by regulating gene expression.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-50
23794249-8	2013	VEGF and sENG mRNA expressions increased in 2.5% compared to 21% O2 , but no protein was detected in the cell supernatants.	Oxygen	65-67	vascular endothelial growth factor A	Homo sapiens	0-4
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	6-12	ATP binding cassette subfamily B member 1	Homo sapiens	135-140
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	6-12	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	6-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	150-155
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	6-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-160
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	104-110	ATP binding cassette subfamily B member 1	Homo sapiens	135-140
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	104-110	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
23954921-3	2013	The sensitivity and response time of the oxygen sensor were evaluated in vitro with a gas pressure chamber system, where oxygen partial pressure was rapidly changed between 5 and 15 kPa, and then in vivo in five healthy adult participants who synchronized their breathing to a metronome set at 10, 20, 30, 40, 50, and 60 breaths min(-1).	Oxygen	41-47	CD59 molecule (CD59 blood group)	Homo sapiens	329-335
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	104-110	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	150-155
23790363-3	2013	Since oxygen is a regulator of multidrug resistance in various tissues, we hypothesized that changes in oxygen tension alter placental ABCB1/P-gp and ABCG2/BCRP expression in the first trimester.	Oxygen	104-110	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-160
23790363-13	2013	CONCLUSION: We conclude that placental multidrug resistance expression, specifically ABCG2, is regulated by oxygen tension in the first trimester.	Oxygen	108-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-90
23744828-5	2013	Surprisingly, pediatric bone marrow and UCB MSCs showed normoxic stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) that is normally degraded completely by HIF prolyl 4-hydroxylases in the presence of oxygen.	Oxygen	212-218	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-113
23179139-7	2013	CD34+ cell counts were positively correlated with oxygen desaturation index (ODI) (r = 0.250, p = 0.041) and duration of oxygen desaturation &lt;90 % (T90) (r = 0.261, p = 0.033) and negatively with minimal oxygen saturation (r = -0.247, p = 0.044) after adjusting for age, glucose, body weight, and smoking status.	Oxygen	50-56	CD34 molecule	Homo sapiens	0-4
23179139-7	2013	CD34+ cell counts were positively correlated with oxygen desaturation index (ODI) (r = 0.250, p = 0.041) and duration of oxygen desaturation &lt;90 % (T90) (r = 0.261, p = 0.033) and negatively with minimal oxygen saturation (r = -0.247, p = 0.044) after adjusting for age, glucose, body weight, and smoking status.	Oxygen	121-127	CD34 molecule	Homo sapiens	0-4
23744828-5	2013	Surprisingly, pediatric bone marrow and UCB MSCs showed normoxic stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) that is normally degraded completely by HIF prolyl 4-hydroxylases in the presence of oxygen.	Oxygen	212-218	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
23179139-7	2013	CD34+ cell counts were positively correlated with oxygen desaturation index (ODI) (r = 0.250, p = 0.041) and duration of oxygen desaturation &lt;90 % (T90) (r = 0.261, p = 0.033) and negatively with minimal oxygen saturation (r = -0.247, p = 0.044) after adjusting for age, glucose, body weight, and smoking status.	Oxygen	121-127	CD34 molecule	Homo sapiens	0-4
23541003-3	2013	We have previously shown that sustained and surface-restricted epidermal growth factor receptor (EGFR) signaling by a tethered form of its prototypal ligand EGF enhances survival of MSC in the presence of death cytokines such as FasL, serum deprivation, and low oxygen in vitro.	Oxygen	262-268	epidermal growth factor receptor	Homo sapiens	63-95
23541003-3	2013	We have previously shown that sustained and surface-restricted epidermal growth factor receptor (EGFR) signaling by a tethered form of its prototypal ligand EGF enhances survival of MSC in the presence of death cytokines such as FasL, serum deprivation, and low oxygen in vitro.	Oxygen	262-268	epidermal growth factor receptor	Homo sapiens	97-101
24224284-7	2013	With the CO boost, N2 washout increased 6% breathing O2 at -15 cmH2O CNPB and INPB, while during normoxic breathing there were 6% and 12% increases due to CNBP, -10 and -15 respectively and 6% with -15cmH2O INPB; breathing 100% O2 yielding 5% to 15% less N2 washout than normoxic breathing.	Oxygen	53-55	troponin T2, cardiac type	Homo sapiens	63-67
23850460-4	2013	The major transcription factor which regulates oxygen tension level is hypoxia-inducible factor-1 alpha (HIF-1alpha).	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-103
23764544-5	2013	Of the MnPs tested, MnT4MPyP exerted the greatest effect on increasing the rate of AscH- oxidation as determined by the concentration of ascorbate radical [Asc -] and the rate of oxygen consumption.	Oxygen	179-185	PYD and CARD domain containing	Homo sapiens	83-86
23850460-4	2013	The major transcription factor which regulates oxygen tension level is hypoxia-inducible factor-1 alpha (HIF-1alpha).	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
23806034-6	2013	In rats, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can also improve insulin sensitivity, secondary to an effective suppression of adiposity.	Oxygen	77-83	insulin	Homo sapiens	127-134
23983604-1	2013	Hypoxia-inducible factor 1 alpha (HIF-1alpha), an essential transcription factor which mediates the adaptation of cells to low oxygen tensions, is regulated precisely by hypoxia and hyperglycemia, which are major determinants of the chronic complications associated with diabetes.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
23983604-1	2013	Hypoxia-inducible factor 1 alpha (HIF-1alpha), an essential transcription factor which mediates the adaptation of cells to low oxygen tensions, is regulated precisely by hypoxia and hyperglycemia, which are major determinants of the chronic complications associated with diabetes.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
23991374-10	2013	RESULTS: TUNEL-positive cells and iNOS immunoreactive neurons were present in the inner nuclear and ganglion cell retinal layers of mice in the high oxygen group.	Oxygen	149-155	nitric oxide synthase 2, inducible	Mus musculus	34-38
23991374-13	2013	The expression of iNOS was significantly higher in the high oxygen group compared with the normal group (t=-21.95, P 14d&lt;0.05; t=-17.30, P 17d&lt;0.05).	Oxygen	60-66	nitric oxide synthase 2, inducible	Mus musculus	18-22
23991374-14	2013	However, the expression of iNOS in the AG treatment group was significantly lower (t=-12.17, P 14d&lt;0.05; t=-10.30, P 17d&lt;0.05) compared with the high oxygen group.	Oxygen	156-162	nitric oxide synthase 2, inducible	Mus musculus	27-31
23850514-9	2013	Further, C60/HSA efficiently generated not only superoxide anion radicals O2 - but also singlet oxygen 1O2 through photoirradiation.	Oxygen	74-76	albumin	Homo sapiens	13-16
23798676-5	2013	The functional significance of CCN1 and its truncated variants was determined in the mouse model of oxygen-induced retinopathy, which simulates neovascular growth associated with PDR and assesses treatment outcomes.	Oxygen	100-106	cellular communication network factor 1	Mus musculus	31-35
23937964-1	2013	BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
23798702-0	2013	Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor/Ca2+ release channel (RyR1): sites and nature of oxidative modification.	Oxygen	0-6	ryanodine receptor 1	Homo sapiens	96-100
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	Oxygen	41-47	ryanodine receptor 1	Homo sapiens	15-19
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	Oxygen	58-60	ryanodine receptor 1	Homo sapiens	15-19
23937964-1	2013	BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
23809096-9	2013	Heart-type fatty acid-binding protein levels in patients treated with HBO were significantly higher than in those treated with normobaric oxygen.	Oxygen	138-144	fatty acid binding protein 3	Homo sapiens	0-37
23336597-0	2013	Novel Nanodimension artificial red blood cells that act as O2 and CO2 carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated PolySFHb-superoxide dismutase-catalase-carbonic anhydrase.	Oxygen	59-61	catalase	Rattus norvegicus	169-177
23664904-3	2013	However, the effect of oxygen levels on the antimicrobial activity of LL-37 remains obscure.	Oxygen	23-29	cathelicidin antimicrobial peptide	Homo sapiens	70-75
23664904-4	2013	In order to test the effect of oxygen (or lack thereof) on LL-37"s activity against E. coli and S. pyogenes, a method for adapting commonly used microtiter plates for real-time growth-kinetic (and growth-inhibition) measurements under anaerobic conditions was developed.	Oxygen	31-37	cathelicidin antimicrobial peptide	Homo sapiens	59-64
23664904-9	2013	The oxygen facultative E. coli grew to a higher density under aerobic conditions and its sensitivity to LL-37 was increased under anaerobiosis.	Oxygen	4-10	cathelicidin antimicrobial peptide	Homo sapiens	104-109
23664904-10	2013	The microaerophilic pathogen S. pyogenes grew faster and to a higher density under anaerobic conditions and was much more resistant to LL-37 under oxygen deprivation.	Oxygen	147-153	cathelicidin antimicrobial peptide	Homo sapiens	135-140
23664904-0	2013	Oxygen deprivation affects the antimicrobial action of LL-37 as determined by microplate real-time kinetic measurements under anaerobic conditions.	Oxygen	0-6	cathelicidin antimicrobial peptide	Homo sapiens	55-60
23336597-4	2013	This resulted in the formation of PLA-PEG-PolySFHb-SOD-CAT-CA nanocapsules that have enhanced antioxidant activity and that can transport both O2 and CO2.	Oxygen	143-145	catalase	Rattus norvegicus	55-58
23710929-0	2013	Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles.	Oxygen	15-21	cytoglobin	Homo sapiens	59-69
23766263-4	2013	APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia.	Oxygen	97-99	NLR family, pyrin domain containing 3	Rattus norvegicus	196-201
23766263-4	2013	APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia.	Oxygen	97-99	interleukin 1 beta	Rattus norvegicus	220-228
23766263-4	2013	APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia.	Oxygen	97-99	interleukin 1 beta	Rattus norvegicus	249-257
23766263-8	2013	CONCLUSIONS: Our findings suggest that in the early stages of O2-induced retinopathy, retinal microglia are activated to produce IL-1beta, which sustains the activation of microglia and induces microvascular injury through the release of Sema3A from adjacent neurons.	Oxygen	62-64	interleukin 1 beta	Rattus norvegicus	129-137
23837729-4	2013	To gain access to the S3 and S3 subpocket of the BACE1 active site, various linkers are described including nitrogen- and oxygen-based, aryl, and amide-based linkers.	Oxygen	122-128	beta-secretase 1	Homo sapiens	49-54
23760768-5	2013	The transcription factor, hypoxia-inducible factor 1 (HIF-1), is a critical mediator of these adaptive responses, and its activation by hypoxia involves O2 -dependent posttranslational modifications and nuclear translocation.	Oxygen	153-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-52
23760768-5	2013	The transcription factor, hypoxia-inducible factor 1 (HIF-1), is a critical mediator of these adaptive responses, and its activation by hypoxia involves O2 -dependent posttranslational modifications and nuclear translocation.	Oxygen	153-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-59
23760768-6	2013	Through the induction of the expression of its target genes, HIF-1 coordinately regulates tissue O2 supply and energetic metabolism.	Oxygen	97-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
23660374-3	2013	In normoxia, HIF is repressed primarily through the action of a family of hydroxylases, which target HIFalpha subunits for degradation in an oxygen-dependent manner.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-109
23740517-6	2013	The preterm and control mice were treated with high oxygen (75%) from postnatal day 7 (P7) to P12.	Oxygen	52-58	polymerase (DNA-directed), delta 4	Mus musculus	94-97
23710929-8	2013	In the low [O2] range (0-50 muM), the Cygb-mediated NO consumption rate is ~ 500 times more sensitive to changes in O2 concentration than that of Mb.	Oxygen	12-14	latexin	Homo sapiens	28-31
23710929-8	2013	In the low [O2] range (0-50 muM), the Cygb-mediated NO consumption rate is ~ 500 times more sensitive to changes in O2 concentration than that of Mb.	Oxygen	12-14	cytoglobin	Homo sapiens	38-42
23710929-8	2013	In the low [O2] range (0-50 muM), the Cygb-mediated NO consumption rate is ~ 500 times more sensitive to changes in O2 concentration than that of Mb.	Oxygen	116-118	latexin	Homo sapiens	28-31
23710929-8	2013	In the low [O2] range (0-50 muM), the Cygb-mediated NO consumption rate is ~ 500 times more sensitive to changes in O2 concentration than that of Mb.	Oxygen	116-118	cytoglobin	Homo sapiens	38-42
23710929-11	2013	Our results suggest that the rapid reduction of Cygb by cellular reductants enables Cygb to efficiently regulate NO metabolism in the vascular wall in an oxygen-dependent manner, but the slow rate of Mb reduction does not show this oxygen dependence.	Oxygen	154-160	cytoglobin	Homo sapiens	48-52
23710929-11	2013	Our results suggest that the rapid reduction of Cygb by cellular reductants enables Cygb to efficiently regulate NO metabolism in the vascular wall in an oxygen-dependent manner, but the slow rate of Mb reduction does not show this oxygen dependence.	Oxygen	154-160	cytoglobin	Homo sapiens	84-88
23456821-3	2013	We validated the use of a reporter containing the oxygen-dependent degradation domain of HIF-1alpha fused to firefly luciferase (ODD-luc) to monitor quantitatively distinct biochemical events leading to hypoxic HIF-1alpha expression or stabilization in a human neuroblastoma cell line (SH-SY5Y).	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
23876042-12	2013	During hyperoxia, Bmp4(+/-) mice were the most susceptible in terms of atrioventricular conduction changes and risk of atrial fibrillation, which may have important implications for patients treated with O2 who also harbor Bmp4 mutations.	Oxygen	204-206	bone morphogenetic protein 4	Mus musculus	18-22
23371827-6	2013	Minute ventilation, oxygen consumption and levels of plasma lactate and norepinephrine were significantly higher (P&lt;0.05) in RAIN than in CON.	Oxygen	20-26	Ras interacting protein 1	Homo sapiens	128-132
23371827-7	2013	In conclusion, the higher oxygen consumption and plasma lactate in RAIN indicated that energy demand increases when running in cold conditions.	Oxygen	26-32	Ras interacting protein 1	Homo sapiens	67-71
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha inhibitor S homeolog	Xenopus laevis	18-24
23867575-3	2013	DBP is currently defined by the need for supplemental oxygen at 28 days of life (mild BPD) and at the 36 weeks of post-menstrual age (moderate and severe BPD).	Oxygen	54-60	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
23727062-10	2013	By constructing Cdh1 expressing lentivirus system, we also found exogenous Cdh1 can down-regulate Skp2 and inhibit reactive astrocyte proliferation induced by oxygen-glucose deprivation and reperfusion.	Oxygen	159-165	cadherin 1	Homo sapiens	75-79
23684380-0	2013	Oxygen tension modulates AQP9 expression in human placenta.	Oxygen	0-6	aquaporin 9	Homo sapiens	25-29
23684380-3	2013	Up to now, the response of AQP9 to changes in the oxygen tension in trophoblast cells is still unknown.	Oxygen	50-56	aquaporin 9	Homo sapiens	27-31
23684380-4	2013	OBJECTIVE: Our aim was to establish whether alterations in oxygen levels may modulate AQP9 expression in human placenta.	Oxygen	59-65	aquaporin 9	Homo sapiens	86-90
23684380-9	2013	However, placental AQP9 decreased abruptly when HIF-1alpha is expressed by deprivation of oxygen or CoCl2 stabilization.	Oxygen	90-96	aquaporin 9	Homo sapiens	19-23
23684380-9	2013	However, placental AQP9 decreased abruptly when HIF-1alpha is expressed by deprivation of oxygen or CoCl2 stabilization.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
23684380-13	2013	CONCLUSION: Our findings suggest that oxygen tension may modulate AQP9 expression in human placenta.	Oxygen	38-44	aquaporin 9	Homo sapiens	66-70
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Oxygen	148-154	cadherin 1	Homo sapiens	42-46
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Oxygen	148-154	cadherin 1	Homo sapiens	105-109
25505656-3	2013	VEGF ensures oxygen supply to the tissues when blood supply is not adequate, or tissue environment is in hypoxic condition.	Oxygen	13-19	vascular endothelial growth factor A	Homo sapiens	0-4
23858469-0	2013	Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease.	Oxygen	0-6	cystathionine beta-synthase	Homo sapiens	47-74
23858469-8	2013	Mitochondrial accumulation of heme oxygenase-1, another heme protein, was also regulated by oxygen level and Lon protease in the same mechanism as for CBS.	Oxygen	35-41	cystathionine beta-synthase	Homo sapiens	151-154
23806450-7	2013	The EPO effect was associated with significantly higher myocardial O2 consumption (12 +- 6 mL/min/unit of tissue vs 6 +- 2 mL/min/unit of tissue, P &lt; 0.017) without effects on myocardial lactate consumption.	Oxygen	67-69	erythropoietin	Sus scrofa	4-7
25505656-5	2013	Cancers that have ability to express VEGF are more efficient to grow and metastasize because solid cancers cannot grow larger than a limited size without adequate blood and oxygen supply.	Oxygen	173-179	vascular endothelial growth factor A	Homo sapiens	37-41
23836652-5	2013	ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis.	Oxygen	263-269	cystathionine beta-synthase	Homo sapiens	28-31
23589424-3	2013	By using sarcosine oxidase (SOD), the photocurrent can be suppressed because of biocatalytic oxygen reduction.	Oxygen	93-99	superoxide dismutase 1	Homo sapiens	9-26
23836663-3	2013	HIF-1alpha stabilization is mediated by VACV protein C16 that binds the human oxygen sensing enzyme prolyl-hydroxylase domain containing protein (PHD)2 and thereby inhibits PHD2-dependent hydroxylation of HIF-1alpha.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
23589424-3	2013	By using sarcosine oxidase (SOD), the photocurrent can be suppressed because of biocatalytic oxygen reduction.	Oxygen	93-99	superoxide dismutase 1	Homo sapiens	28-31
23836663-3	2013	HIF-1alpha stabilization is mediated by VACV protein C16 that binds the human oxygen sensing enzyme prolyl-hydroxylase domain containing protein (PHD)2 and thereby inhibits PHD2-dependent hydroxylation of HIF-1alpha.	Oxygen	78-84	egl-9 family hypoxia inducible factor 1	Homo sapiens	146-151
23836663-3	2013	HIF-1alpha stabilization is mediated by VACV protein C16 that binds the human oxygen sensing enzyme prolyl-hydroxylase domain containing protein (PHD)2 and thereby inhibits PHD2-dependent hydroxylation of HIF-1alpha.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	205-215
23694817-3	2013	Prolyl hydroxylase domain protein 2 (PHD2) is a cellular oxygen sensor that regulates 2 key transcription factors involved in cell survival and inflammation: hypoxia-inducible factor and nuclear factor-kappaB.	Oxygen	57-63	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
23695032-0	2013	Tuning affinity and reversibility for O2 binding in dinuclear Co(II) complexes.	Oxygen	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
23695032-6	2013	Using density functional theory calculations, we conclude that the Co(II) atoms of the deoxy complexes coordinate solvent molecules as auxiliary ligands and that a conformation change of the ligand is involved in the reversible O2 binding process.	Oxygen	228-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23694817-3	2013	Prolyl hydroxylase domain protein 2 (PHD2) is a cellular oxygen sensor that regulates 2 key transcription factors involved in cell survival and inflammation: hypoxia-inducible factor and nuclear factor-kappaB.	Oxygen	57-63	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
23796364-1	2013	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival, and progression of tumors.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
23750001-1	2013	Hypoxia-inducible factor (HIF) 1 and HIF-2 are heterodimeric proteins composed of an oxygen-regulated HIF-1alpha or HIF-2alpha subunit, respectively, and a constitutively expressed HIF-1beta subunit, which mediate adaptive transcriptional responses to hypoxia.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
23750001-1	2013	Hypoxia-inducible factor (HIF) 1 and HIF-2 are heterodimeric proteins composed of an oxygen-regulated HIF-1alpha or HIF-2alpha subunit, respectively, and a constitutively expressed HIF-1beta subunit, which mediate adaptive transcriptional responses to hypoxia.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
23750456-11	2013	As a consequence of its apparent high reactivity, the FpR intermediate was observed to undergo oxidation under oxygen-saturated conditions to yield another radical species, denoted as FOR, which subsequently underwent intramolecular hydrogen transfer (IHT) and dehydroxylation (DHO) to form a final product, which could react with the carboxyl from the decarboxylation reaction to generate a minor final product.	Oxygen	111-117	formyl peptide receptor 1	Homo sapiens	54-57
23829766-5	2013	This insight derived through a detailed quantitative analysis of the stereocontrolling transition states suggests that the commonly found interpretations solely based on steric interactions between the incoming oxygen and the protruding angular methyl groups (C10, C13 methyls) in the beta face calls for adequate refinement.	Oxygen	211-217	homeobox C10	Homo sapiens	260-263
23796364-1	2013	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival, and progression of tumors.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
23874855-4	2013	Cells with elevated NQO1 levels exhibited higher levels of oxygen consumption and ATP production, and lower production of reactive oxygen species.	Oxygen	59-65	NAD(P)H quinone dehydrogenase 1	Homo sapiens	20-24
23882269-9	2013	Under both oxygen levels ASC were capable of strong upregulation of the immunomodulatory molecules indoleamine 2,3-dioxygenase (IDO) and programed death ligand-1 upon stimulation with IFN-gamma and TNF-alpha, and, in addition, IDO activity as measured by the accumulation of l-kynurenine was not affected under hypoxia.	Oxygen	11-17	interferon gamma	Homo sapiens	184-193
23695215-6	2013	Exercise capacity was significantly reduced in LKB1-DN mice, with a marked reduction in oxygen consumption and carbon dioxide production during exercise.	Oxygen	88-94	serine/threonine kinase 11	Mus musculus	47-51
23695215-9	2013	We concluded that LKB1 in the skeletal muscle contributes significantly to exercise capacity and oxygen uptake during exercise.	Oxygen	97-103	serine/threonine kinase 11	Mus musculus	18-22
23663895-0	2013	NR4A1 enhances neural survival following oxygen and glucose deprivation: an in vitro study.	Oxygen	41-47	nuclear receptor subfamily 4 group A member 1	Homo sapiens	0-5
23663895-4	2013	Our results showed that oxygen and glucose deprivation (OGD) dramatically induced primary culture neural cell apoptosis and NR4A1 expression at both protein and mRNA level.	Oxygen	24-30	nuclear receptor subfamily 4 group A member 1	Homo sapiens	124-129
23603614-4	2013	It was found that hypoxia (3% O2) significantly affected the expression of a range of angiogenesis-related factors including VEGF, angiogenin and thrombospondin-1, relative to the normoxic baseline.	Oxygen	30-32	vascular endothelial growth factor A	Homo sapiens	125-129
23603614-4	2013	It was found that hypoxia (3% O2) significantly affected the expression of a range of angiogenesis-related factors including VEGF, angiogenin and thrombospondin-1, relative to the normoxic baseline.	Oxygen	30-32	thrombospondin 1	Homo sapiens	146-162
23874890-8	2013	As the hypoxia-inducible factor-1alpha (HIF-1alpha) is stabilised in hypoxia and plays a pivotal role in the transcriptional response to changes in oxygen availability we used an shRNA-approach to examine the role of HIF-1alpha in cytoskeleton-related architecture and functions.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	7-38
23874890-8	2013	As the hypoxia-inducible factor-1alpha (HIF-1alpha) is stabilised in hypoxia and plays a pivotal role in the transcriptional response to changes in oxygen availability we used an shRNA-approach to examine the role of HIF-1alpha in cytoskeleton-related architecture and functions.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Oxygen	255-261	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Oxygen	255-261	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
23702615-7	2013	Among them, the microfluidic oxygenator with porous PDMS membrane has the highest gas exchange rate of 1.46 muL min(-1) cm(2) for oxygen and 5.27 muL min(-1) cm(2) for carbon dioxide and performs better than a commercial hollow fiber-based oxygenator by 367 and 233%, respectively.	Oxygen	29-35	CD59 molecule (CD59 blood group)	Homo sapiens	112-118
23652801-9	2013	CONCLUSIONS: This first description of the role of UCP2 in oxygen sensing and in pulmonary hypertension vascular remodeling may open a new window in biomarker and therapeutic strategies.	Oxygen	59-65	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	51-55
23702615-7	2013	Among them, the microfluidic oxygenator with porous PDMS membrane has the highest gas exchange rate of 1.46 muL min(-1) cm(2) for oxygen and 5.27 muL min(-1) cm(2) for carbon dioxide and performs better than a commercial hollow fiber-based oxygenator by 367 and 233%, respectively.	Oxygen	29-35	CD59 molecule (CD59 blood group)	Homo sapiens	150-156
23418947-4	2013	AIM: We hypothesized that acute exposure to normobaric hypoxia (11% O2 ) would repress the activation of the mTOR pathway usually observed after a meal and would activate the proteolytic pathways in skeletal muscle.	Oxygen	68-70	mechanistic target of rapamycin kinase	Homo sapiens	109-113
23742069-1	2013	Factor inhibiting hypoxia-inducible factor (FIH) is an alpha-ketoglutarate (alphaKG)-dependent enzyme which catalyzes hydroxylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and plays an important role in cellular oxygen sensing and hypoxic response.	Oxygen	285-291	hypoxia inducible factor 1 subunit alpha	Homo sapiens	200-231
23742069-1	2013	Factor inhibiting hypoxia-inducible factor (FIH) is an alpha-ketoglutarate (alphaKG)-dependent enzyme which catalyzes hydroxylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and plays an important role in cellular oxygen sensing and hypoxic response.	Oxygen	285-291	hypoxia inducible factor 1 subunit alpha	Homo sapiens	233-243
23618787-2	2013	This is in contrast to the reduction of O2 in cytochrome c oxidase (CcO), the other member of the heme-copper oxidase family, which stores energy by the generation of a membrane gradient.	Oxygen	40-42	cytochrome c, somatic	Homo sapiens	46-58
23640575-6	2013	Moreover, in vivo delivery of siRNA targeting apelin, which causes exuberant endothelial cell proliferation and pathological angiogenesis through its receptor APJ, led to increased pericyte coverage and suppressed pathological angiogenesis in an oxygen-induced retinopathy model.	Oxygen	246-252	apelin	Homo sapiens	46-52
23673340-7	2013	Expanding roles for MYC, PI3K and TP53 in regulating reactive oxygen production, glycolysis and glutaminolysis in lymphoma cells have been described.	Oxygen	62-68	tumor protein p53	Homo sapiens	34-38
24455878-2	2013	The yield of chemiluminescence exceeds spontaneous light from Fenton solution at [Asc] - 10(-4) - 10(-3) mol/l in the presence of dissolved oxygen, and prooxidant properties are displayed.	Oxygen	140-146	PYD and CARD domain containing	Homo sapiens	82-85
23862672-0	2013	The bioanalytical molecular pharmacology of the N-methyl-D-aspartate (NMDA) receptor nexus and the oxygen-responsive transcription factor HIF-1alpha: putative mechanisms and regulatory pathways unravel the intimate hypoxia connection.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
23815641-2	2013	In this reaction, the ONO ligand undergoes a two-electron reduction, with concomitant oxidation of PPh3 to OPPh3 and transformation of the dioxorhenium(V) fragment into a monooxorhenium(V) fragment, constituting a net nonclassical oxygen atom transfer.	Oxygen	231-237	caveolin 1	Homo sapiens	99-103
22985061-9	2013	CONCLUSIONS: The increase in telomerase activity and TRF1 protein expression of vascular endothelial cell might show an aspect of cellular protective reaction against oxygen stress.	Oxygen	167-173	telomeric repeat binding factor 1	Homo sapiens	53-57
23701276-2	2013	Cellular response to reduced oxygen levels is mediated by the transcriptional regulator hypoxia-inducible factor-1 (HIF-1).	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-114
23701276-2	2013	Cellular response to reduced oxygen levels is mediated by the transcriptional regulator hypoxia-inducible factor-1 (HIF-1).	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
23701276-3	2013	It is a heterodimeric complex protein consisting of an oxygen dependent subunit (HIF-1alpha) and a constitutively expressed nuclear subunit (HIF-1beta).	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
23701276-8	2013	Further, various inhibitors of HIF-1 pathway that may have a viable potential in the treatment of oxygen-dependent ocular diseases are also discussed.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-36
23862672-6	2013	The NMDAR connection with hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor considered master regulator of oxygen sensing mechanisms, is not well established in the CNS.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-57
23862672-6	2013	The NMDAR connection with hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor considered master regulator of oxygen sensing mechanisms, is not well established in the CNS.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
23354880-3	2013	To elucidate the mechanism by which GALP exerts its effect on energy homeostasis, urethane-anesthetized rats were intracerebroventricularly injected with GALP or saline, after which oxygen consumption, heart rate, and body temperature were monitored for 4 h. In some cases, animals were also pretreated with the cyclooxygenase (COX) inhibitor, diclofenac, via intracerebroventricular (i.c.v.)	Oxygen	182-188	galanin-like peptide	Rattus norvegicus	36-40
23728938-2	2013	Western blot analysis revealed that along with an upregulation of hypoxia-inducible factor-1alpha, there was a time-dependent induction of periostin in MKN-45 cells under hypoxia (2% O2 ), increasing by eightfold as compared to normoxic cells.	Oxygen	183-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-97
23699668-3	2013	Hypoxia-inducible factor-1 (HIF-1) is a key player in the transcriptional response to low oxygen tension in many types of cancer.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
23699668-3	2013	Hypoxia-inducible factor-1 (HIF-1) is a key player in the transcriptional response to low oxygen tension in many types of cancer.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
23562913-0	2013	Role of HIF1alpha and PKCbeta in mediating the effect of oxygen and glucose in a novel wound assay.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-17
23462455-5	2013	Hyperbaric oxygen therapy treatment significantly decreased the elevated tissue malondialdehyde level, myeloperoxidase activity, and hydroxyproline content and increased the reduced superoxide dismutase and catalase activities and glutathione level in the tissues.	Oxygen	11-17	catalase	Rattus norvegicus	207-215
23681751-7	2013	In addition, the DSE feeding as well as bezafibrate (a PPAR-alpha potent agonist) feeding increased oxygen consumption rate and rectal temperature.	Oxygen	100-106	peroxisome proliferator activated receptor alpha	Mus musculus	55-65
23957201-4	2013	The results showed that the ERK and p38 were phosphorylated at two hours and reached a peak at six hours into exposure to hyperbaric oxygen.	Oxygen	133-139	Eph receptor B1	Rattus norvegicus	28-31
23394201-8	2013	Results show a downregulation of the osteogenic markers (ALP activity, mineralization, ON, OPN) in both 1% and 2% O2 when compared to 20% O2 in both 2-D and 3-D culture.	Oxygen	114-116	alkaline phosphatase, placental	Homo sapiens	57-60
23394201-9	2013	Vascular endothelial growth factor secretion over 28 days was significantly higher in low O2 environments and HIF-1 inhibition reduced this effect.	Oxygen	90-92	vascular endothelial growth factor A	Homo sapiens	0-34
23645533-9	2013	CDH5 expression was significantly upregulated in GSCs, but not in non-GSCs or normal neural stem cells, under a 1% O2 condition.	Oxygen	115-117	cadherin 5	Homo sapiens	0-4
24403689-1	2013	PURPOSE: To examine the response of cerebral oxygenation during treadmill walking in a person with Parkinson disease (PD) who experiences freezing of gait (FOG) and to determine whether the oxygen response was related to the timing of his PD medication.	Oxygen	45-51	zinc finger protein, FOG family member 1	Homo sapiens	156-159
24403689-4	2013	Cerebral oxygen response (measured by near-infrared spectroscopy) was stable until the FOG episodes occurred, at which point it decreased until the FOG episode was over.	Oxygen	9-15	zinc finger protein, FOG family member 1	Homo sapiens	148-151
24403689-8	2013	IMPLICATIONS: Haemodynamic and cerebral oxygen changes occurred that were specific to the timing of the client"s PD medication and to his FOG episodes.	Oxygen	40-46	zinc finger protein, FOG family member 1	Homo sapiens	138-141
23957201-8	2013	These results demonstrated different changes of activation of ERK and p38 during lung injury induced by prolonged exposure to hyperbaric oxygen.	Oxygen	137-143	Eph receptor B1	Rattus norvegicus	62-65
23809189-7	2013	RESULTS: Additional oxygen uptake increased over the frequency range to a maximum of 564 (SD 114) ml min-1 at 12 Hz, and the respiratory exchange ratio was close to unity from 4 to 12 Hz.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	101-106
23731014-1	2013	The hypoxia-inducible factor-1 (HIF-1) transcription factor regulates cellular oxygen homeostasis.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
23785333-4	2013	Low oxygen tensions (hypoxia) and immunosuppressive cytokines inhibit iNOS activity and lead to production of low amounts of NO/RNS, which are pro-angiogenic and support tumor growth and metastasis by inducing growth factors (e.g., VEGF) and matrix metalloproteinases (MMPs).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	232-236
23731014-1	2013	The hypoxia-inducible factor-1 (HIF-1) transcription factor regulates cellular oxygen homeostasis.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
23805218-10	2013	Co-overexpression of SelR and Clu in N2aSW cells, an AD model cell line, significantly decreased the level of intracellular reactive oxygen species.	Oxygen	133-139	methionine sulfoxide reductase B1	Mus musculus	21-25
23801966-3	2013	FOXO3 also regulates the adaptation to hypoxia by reducing mitochondrial mass and oxygen consumption during HIF-1alpha activation.	Oxygen	82-88	forkhead box O3	Homo sapiens	0-5
23785333-4	2013	Low oxygen tensions (hypoxia) and immunosuppressive cytokines inhibit iNOS activity and lead to production of low amounts of NO/RNS, which are pro-angiogenic and support tumor growth and metastasis by inducing growth factors (e.g., VEGF) and matrix metalloproteinases (MMPs).	Oxygen	4-10	nitric oxide synthase 2	Homo sapiens	70-74
23225569-1	2013	The prolyl-4-hydroxylase domain 1-3 (PHD1-3) enzymes are regulating the protein stability of the alpha-subunit of the hypoxia-inducible factor-1 (HIF-1), which mediates oxygen-dependent gene expression.	Oxygen	169-175	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-151
23675962-0	2013	Covalent core-shell architecture of hemoglobin and human serum albumin as an artificial O2 carrier.	Oxygen	88-90	albumin	Homo sapiens	57-70
23826414-1	2013	OBJECTIVE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on the iNOS mRNA-iNOS-NO signaling pathway and neurofunction protected in a rat spinal cord injury model.	Oxygen	51-57	nitric oxide synthase 2	Rattus norvegicus	80-84
23826414-1	2013	OBJECTIVE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on the iNOS mRNA-iNOS-NO signaling pathway and neurofunction protected in a rat spinal cord injury model.	Oxygen	51-57	nitric oxide synthase 2	Rattus norvegicus	90-94
23635431-12	2013	Through this modification, the oxygen permeability decreased further and was below 17 cm(3) mum m(-2) d(-1) kPa(-1) even at 97.4% RH, and the water vapor transmission rate decreased from 600 to 40 g/m(2) day.	Oxygen	31-37	latexin	Homo sapiens	92-95
23732018-8	2013	Limbal epithelial cells expanded in 2% O2 exhibited slow growth, low fraction of cells in S/G2 , high CFE, high expression of stem cell markers ABCG2 and p63alpha, and low fraction of differentiation marker CK3 resembling a LESC phenotype.	Oxygen	39-41	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-149
23515531-8	2013	Our data demonstrate that depletion of oxygen or fuel results in repression or induction, respectively, of PGC-1alpha expression via discrete mechanisms, which may contribute to cardiac energetic derangement during hypoxia, ischemia, and failure.	Oxygen	39-45	PPARG coactivator 1 alpha	Rattus norvegicus	107-117
23492967-12	2013	Computer modeling studies predicted that etomidate, carboetomidate, and azi-etomidate can fit into the heme-containing pocket that forms 11beta-hydroxylase"s active site and pose with their carbonyl oxygens interacting with the heme iron and their phenyl rings stacking with phenylalanine-80.	Oxygen	199-206	antizyme inhibitor 1	Homo sapiens	72-75
23970920-3	2013	Several evidences have demonstrated that angiogenesis sustains inflammation by preparing oxygen and nutrients for inflammatory cells and inflammation in turn can cause insulin resistance, type 2 diabetes, and cardiovascular disease.	Oxygen	89-95	insulin	Homo sapiens	168-175
23847732-2	2013	We demonstrate a combined optical system using two-photon phosphorescence lifetime and fluorescence microscopy (2PLM) to characterize the partial pressure of oxygen (pO2) in single descending cortical arterioles in the mouse brain before and after generating a targeted photothrombotic occlusion.	Oxygen	158-164	FXYD domain-containing ion transport regulator 1	Mus musculus	113-116
23458834-2	2013	HIF-1 is involved in cellular homeostasis under hypoxia, in development and in several diseases affected by oxygen availability, particularly cancer.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
23723163-11	2013	Myofibroblast differentiation and alveolar development was unaffected in Postn null mice and acute 85%-O2 exposure equally inhibited septal formation in Postn null and wild-type littermates.	Oxygen	103-105	periostin, osteoblast specific factor	Mus musculus	153-158
23723163-9	2013	Initially, 85%-O2 prematurely downregulated Postn and alphaSMA expression and suppressed proliferation before the first evidence of distal lung simplification at P4.	Oxygen	15-17	periostin, osteoblast specific factor	Mus musculus	44-49
23723163-9	2013	Initially, 85%-O2 prematurely downregulated Postn and alphaSMA expression and suppressed proliferation before the first evidence of distal lung simplification at P4.	Oxygen	15-17	actin alpha 2, smooth muscle, aorta	Mus musculus	54-62
23519896-3	2013	We found that pathophysiological hypoxia (&lt;2% O2 ) significantly decreased CD4(+) T-cell survival after mitogenic stimulation.	Oxygen	49-51	CD4 molecule	Homo sapiens	78-81
23723163-10	2013	By P14, chronic 85%-O2 resulted in secondary upregulation of Postn and alphaSMA in blunted septa.	Oxygen	20-22	SUB1 homolog, transcriptional regulator	Mus musculus	3-6
23723163-10	2013	By P14, chronic 85%-O2 resulted in secondary upregulation of Postn and alphaSMA in blunted septa.	Oxygen	20-22	periostin, osteoblast specific factor	Mus musculus	61-66
23723163-10	2013	By P14, chronic 85%-O2 resulted in secondary upregulation of Postn and alphaSMA in blunted septa.	Oxygen	20-22	actin alpha 2, smooth muscle, aorta	Mus musculus	71-79
23438722-6	2013	RESULTS: Oxygen uptake was lower during room temp than during cold recovery (0.40 +- 0.05 L x min-1 vs. 0.80 +- 0.12 L x min-1; p&lt;0.01).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
23438722-6	2013	RESULTS: Oxygen uptake was lower during room temp than during cold recovery (0.40 +- 0.05 L x min-1 vs. 0.80 +- 0.12 L x min-1; p&lt;0.01).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
23529663-3	2013	HIF1A is the major sensor of oxygen concentration in mammalian cells.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
23534609-6	2013	BMSCs protected against neonatal rat hyperoxic lung injury during recovery as demonstrated by enhanced expression of AQP5 and SP-C, likely due to the suppression of alveolar cell apoptosis and lung inflammation responses to oxygen with up-regulation of the expression of BCL-2 gene and down-regulation of the expression of BAX gene and stimulation of vascular endothelial growth factor and so on.	Oxygen	224-230	surfactant protein C	Rattus norvegicus	126-130
23947022-2	2013	The effects of O2 and H2 in Ar gas on the removal of CS2 were examined.	Oxygen	15-17	chorionic somatomammotropin hormone 2	Homo sapiens	53-56
23947022-4	2013	The decomposition of CS2 was improved in the presence of O2 in gas stream and the maximal removal was over 97%.	Oxygen	57-59	chorionic somatomammotropin hormone 2	Homo sapiens	21-24
23529546-7	2013	The consumption of oxygen induced by SIN-1 was found to not be affected by 5-ASA at 0.1-50 mM, indicating that 5-ASA at these concentrations is not involved in the auto-oxidation of SIN-1 to form peroxynitrite.	Oxygen	19-25	MAPK associated protein 1	Homo sapiens	37-42
23947022-5	2013	The main gaseous products of CS2 decomposition with the addition of O2 in Ar gas were CO, CO2 COS and SO2, while, with the presence of H2 in Ar gas, the main products of CS2 decomposition were H2S and CH4.	Oxygen	68-70	chorionic somatomammotropin hormone 2	Homo sapiens	29-32
23479280-1	2013	A series of no-chlorine and oxygen-rich hydrazine derivatives (hydrazine modified with -NO2 and NO3(-) groups) was designed and optimized to obtain molecular geometries and electronic structures at density functional theory-B3PW91/6-311++G(3df,3pd) level.	Oxygen	28-34	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
23378030-0	2013	Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.	Oxygen	78-84	nuclear receptor subfamily 2 group F member 2	Homo sapiens	147-152
23474170-10	2013	The targeting of iNOS protein to the peroxisome may shift the balance of metabolic processes that rely on heme proteins susceptible to modification by radical oxygen and nitrogen radicals.	Oxygen	159-165	nitric oxide synthase 2, inducible	Mus musculus	17-21
23540714-3	2013	Functional studies in genetic models show that ADORA2B signaling attenuates myocardial infarction by adapting metabolism towards more oxygen efficient utilization of carbohydrates.	Oxygen	134-140	adenosine A2b receptor	Homo sapiens	47-54
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	69-71	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	69-71	superoxide dismutase 2, mitochondrial	Mus musculus	32-37
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	69-71	catalase	Mus musculus	194-202
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	69-71	catalase	Mus musculus	204-207
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	224-230	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
23649652-1	2013	Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen.	Oxygen	224-230	superoxide dismutase 2, mitochondrial	Mus musculus	32-37
23671091-2	2013	The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.	Oxygen	106-112	AKT serine/threonine kinase 1	Homo sapiens	11-14
23611775-1	2013	Hypoxia-inducible factor 1alpha (HIF-1alpha) is an oxygen-sensitive subunit of HIF-1, the master transcription factor for cellular response to hypoxia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23609931-0	2013	PdCl2 and N-hydroxyphthalimide co-catalyzed C(sp2)-H hydroxylation by dioxygen activation.	Oxygen	70-78	Sp2 transcription factor	Homo sapiens	44-49
23611775-1	2013	Hypoxia-inducible factor 1alpha (HIF-1alpha) is an oxygen-sensitive subunit of HIF-1, the master transcription factor for cellular response to hypoxia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23611775-1	2013	Hypoxia-inducible factor 1alpha (HIF-1alpha) is an oxygen-sensitive subunit of HIF-1, the master transcription factor for cellular response to hypoxia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
23560683-7	2013	At the same time, the oxygen-scavenging ability of glucose oxidase (GO) and catalase (CAT) is synergistically employed to prevent sample photodegradation.	Oxygen	22-28	catalase	Homo sapiens	86-89
23671581-1	2013	Hypoxia-inducible factor 1alpha (HIF1alpha) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23282141-3	2013	A single in vitro exposure of ASCs to severe hypoxia (&lt;0.1% O2) significantly increased both the transcriptional and translational level of the vascular endothelial growth factor-A (VEGF-A) and angiogenin (ANG).	Oxygen	63-65	vascular endothelial growth factor A	Homo sapiens	147-183
23282141-3	2013	A single in vitro exposure of ASCs to severe hypoxia (&lt;0.1% O2) significantly increased both the transcriptional and translational level of the vascular endothelial growth factor-A (VEGF-A) and angiogenin (ANG).	Oxygen	63-65	vascular endothelial growth factor A	Homo sapiens	185-191
23704930-6	2013	Overexpression of APOOL led to fragmentation of mitochondria, a reduced basal oxygen consumption rate, and altered cristae morphology.	Oxygen	78-84	apolipoprotein O like	Homo sapiens	18-23
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Oxygen	281-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Oxygen	331-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23471155-8	2013	Whereas in complex 3, H2L(-) ligand links two Co(II) centers via one oxygen and one sulphur atoms.	Oxygen	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
23671581-1	2013	Hypoxia-inducible factor 1alpha (HIF1alpha) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
23671581-1	2013	Hypoxia-inducible factor 1alpha (HIF1alpha) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP.	Oxygen	152-158	CREB binding protein	Homo sapiens	223-226
23713218-5	2013	RESULTS: Peak oxygen uptake during exercise using RAD and C2 averaged 3.11 +/- 0.49 and 3.18 +/- 0.50 L x min(-1), respectively.	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	106-112
23644619-1	2013	Controlled oxygen reperfusion could protect the lung against ischemia-reperfusion injury in cardiopulmonary bypass (CPB) by downregulating high mobility group box 1 (HMGB1), a high affinity receptor of HMGB1.	Oxygen	11-17	high mobility group box 1	Canis lupus familiaris	139-164
23725836-9	2013	CONCLUSION: IFP and delivery of oxygen might be improved by rebalance of Ang-1/Ang-2 under the treatment of EGCG in NSCLC, which also acts as a sensitizer of chemotherapy.	Oxygen	32-38	angiopoietin 1	Mus musculus	73-78
23644619-1	2013	Controlled oxygen reperfusion could protect the lung against ischemia-reperfusion injury in cardiopulmonary bypass (CPB) by downregulating high mobility group box 1 (HMGB1), a high affinity receptor of HMGB1.	Oxygen	11-17	high mobility group box 1	Canis lupus familiaris	166-171
23644619-1	2013	Controlled oxygen reperfusion could protect the lung against ischemia-reperfusion injury in cardiopulmonary bypass (CPB) by downregulating high mobility group box 1 (HMGB1), a high affinity receptor of HMGB1.	Oxygen	11-17	high mobility group box 1	Canis lupus familiaris	202-207
23421720-9	2013	On the other hand, circadian transgenic zebrafish cells, simulating a repressed or an overstimulated circadian clock, modified gene transcription levels of oxygen-regulated genes such as erythropoietin and vascular endothelial growth factor 165 and altered the hypoxia-induced increase in Hif-1alpha protein concentration.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha a	Danio rerio	289-299
23725836-9	2013	CONCLUSION: IFP and delivery of oxygen might be improved by rebalance of Ang-1/Ang-2 under the treatment of EGCG in NSCLC, which also acts as a sensitizer of chemotherapy.	Oxygen	32-38	angiogenin, ribonuclease A family, member 2	Mus musculus	79-84
23905311-5	2013	Results show that the spectral line intensity from oxygen atom increases with increasing the peak value of the applied voltage, increases with increasing the gas flow rate, reaches its maximum with a gas flow rate of 30 L x min(-1) and then decreases with further increasing the gas flow rate.	Oxygen	51-57	CD59 molecule (CD59 blood group)	Homo sapiens	224-230
23306842-1	2013	BACKGROUND AND AIMS: Cytoglobin (Cygb) is the newest globin family and is upregulated during hypoxia to maintain the oxygen status.	Oxygen	117-123	cytoglobin	Rattus norvegicus	21-31
23306842-1	2013	BACKGROUND AND AIMS: Cytoglobin (Cygb) is the newest globin family and is upregulated during hypoxia to maintain the oxygen status.	Oxygen	117-123	cytoglobin	Rattus norvegicus	33-37
23398717-7	2013	Our results suggest that optimized expression levels of GRE3, XYL2, and XYL3 could overcome redox imbalance during xylose fermentation by engineered S. cerevisiae under oxygen-limited conditions.	Oxygen	169-175	trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))	Saccharomyces cerevisiae S288C	56-60
23416721-3	2013	Insulin, oxygen and amino acid concentrations may regulate the mammalian target of rapamycin (mTOR) nutrient sensor in the human placenta affecting trophoblast metabolism and nutrient delivery.	Oxygen	9-15	mechanistic target of rapamycin kinase	Homo sapiens	63-92
23416721-3	2013	Insulin, oxygen and amino acid concentrations may regulate the mammalian target of rapamycin (mTOR) nutrient sensor in the human placenta affecting trophoblast metabolism and nutrient delivery.	Oxygen	9-15	mechanistic target of rapamycin kinase	Homo sapiens	94-98
23416112-7	2013	Furthermore, the CKB knockdown reduced glucose consumption and lactate production, and increased ROS production and oxygen consumption.	Oxygen	116-122	creatine kinase B	Homo sapiens	17-20
23391748-3	2013	Heme oxygenase-1 (HO-1), an oxygen-dependent enzyme regulating vascular tone and cell proliferation, was implicated in HPH and was promoted by hypoxia.	Oxygen	5-11	heme oxygenase 1	Mus musculus	18-22
23449935-3	2013	We report that IL-6 knockout (KO) mice, 4 mo of age, have similar body weight to wild-type (WT), and, under resting conditions, oxygen consumption, food intake, substrate utilization, glucose tolerance, and insulin sensitivity are not different.	Oxygen	128-134	interleukin 6	Mus musculus	15-19
23989819-15	2013	The low S100beta variance during the fluid restrictive MCABG technique may be due to more efficient oxygen transport to the brain provided by significantly higher perioperative Ht levels.	Oxygen	100-106	S100 calcium binding protein B	Homo sapiens	8-16
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Oxygen	226-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22692861-8	2013	The discrepant results between in vitro and in vivo data were attributed to biphasic oxygen dependent expression of monocarboxylate transporter-1 in vivo.	Oxygen	85-91	solute carrier family 16 (monocarboxylic acid transporters), member 1	Mus musculus	116-145
23635654-6	2013	Treatment with CHK1 inhibitors during acute or prolonged hypoxia (&lt; 0.03%, 0.2%, and 1% O2; 3 h or 20-24 h) gave similar effects on cell survival as treatment with these inhibitors during normoxia.	Oxygen	91-93	checkpoint kinase 1	Homo sapiens	15-19
23756005-7	2013	Peak oxygen consumption ranged from 21.8 +- 3.8 to 40.0 +- 3.4 mL kg(-1) min(-1) during cutting activities and a search and rescue task, respectively, representing values similar to or higher than the current entry standards.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	73-79
23777106-4	2013	Besides its function as O2, carbon monoxide, and nitric oxide-binding molecule, cytoglobin exhibits antioxidative properties under hypoxic condition.	Oxygen	24-26	cytoglobin	Homo sapiens	80-90
23478801-12	2013	Mutation of Ngb at its oxygen-binding site (H64L) abolished the inhibitory effects of Ngb on Erk activation and HepG2 cell proliferation.	Oxygen	23-29	mitogen-activated protein kinase 1	Homo sapiens	93-96
23478801-13	2013	Therefore, we propose that Ngb controls HCC development by linking oxygen/ROS signals to oncogenic Raf/mitogen-activated protein kinase (MAPK)/Erk signaling.	Oxygen	67-73	mitogen-activated protein kinase 1	Homo sapiens	143-146
23525349-8	2013	Following 12 h of exposure, the expression of the Wnt signaling pathway in the high volume oxygen fraction (&gt;0.95) group was significantly higher, whereas it decreased after 24 h of exposure.	Oxygen	91-97	Wnt family member 5A	Rattus norvegicus	50-53
23634216-1	2013	P450(cam) (CYP101A1) is a bacterial monooxygenase that is known to catalyze the oxidation of camphor, the first committed step in camphor degradation, with simultaneous reduction of oxygen (O2).	Oxygen	40-46	calmodulin 3	Homo sapiens	0-9
23634216-6	2013	This reaction has an adaptive value to bacteria that express this camphor catabolism pathway, which requires O2, for two reasons: 1) the borneol and H2O2 mixture generated is toxic to other bacteria and 2) borneol down-regulates the expression of P450(cam) and its electron transfer partners.	Oxygen	109-111	calmodulin 3	Homo sapiens	247-256
23638125-0	2013	The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.	Oxygen	95-101	adenosine A2b receptor	Homo sapiens	35-42
23634216-1	2013	P450(cam) (CYP101A1) is a bacterial monooxygenase that is known to catalyze the oxidation of camphor, the first committed step in camphor degradation, with simultaneous reduction of oxygen (O2).	Oxygen	190-192	calmodulin 3	Homo sapiens	0-9
23634216-2	2013	We report that P450(cam) catalysis is controlled by oxygen levels: at high O2 concentration, P450(cam) catalyzes the known oxidation reaction, whereas at low O2 concentration the enzyme catalyzes the reduction of camphor to borneol.	Oxygen	52-58	calmodulin 3	Homo sapiens	15-24
23634216-2	2013	We report that P450(cam) catalysis is controlled by oxygen levels: at high O2 concentration, P450(cam) catalyzes the known oxidation reaction, whereas at low O2 concentration the enzyme catalyzes the reduction of camphor to borneol.	Oxygen	52-58	calmodulin 3	Homo sapiens	93-102
23634216-2	2013	We report that P450(cam) catalysis is controlled by oxygen levels: at high O2 concentration, P450(cam) catalyzes the known oxidation reaction, whereas at low O2 concentration the enzyme catalyzes the reduction of camphor to borneol.	Oxygen	75-77	calmodulin 3	Homo sapiens	15-24
23634216-2	2013	We report that P450(cam) catalysis is controlled by oxygen levels: at high O2 concentration, P450(cam) catalyzes the known oxidation reaction, whereas at low O2 concentration the enzyme catalyzes the reduction of camphor to borneol.	Oxygen	75-77	calmodulin 3	Homo sapiens	93-102
23634216-2	2013	We report that P450(cam) catalysis is controlled by oxygen levels: at high O2 concentration, P450(cam) catalyzes the known oxidation reaction, whereas at low O2 concentration the enzyme catalyzes the reduction of camphor to borneol.	Oxygen	158-160	calmodulin 3	Homo sapiens	15-24
23416151-10	2013	Correspondingly, exposing murine microglial BV2 cells to hypoxia (1% O2) for 20h resulted in an increased expression of TNF-alpha, CD14, iNOS, and nitrotyrosine.	Oxygen	69-71	tumor necrosis factor	Mus musculus	120-129
23626778-1	2013	Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1alpha by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
23626778-1	2013	Oxygen sensing transcription factor HIF-1 is activated due to accumulation of regulatory subunit HIF-1alpha by posttranslational stability mechanism during hypoxia or by several other stimuli even in normoxia.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
23416151-10	2013	Correspondingly, exposing murine microglial BV2 cells to hypoxia (1% O2) for 20h resulted in an increased expression of TNF-alpha, CD14, iNOS, and nitrotyrosine.	Oxygen	69-71	nitric oxide synthase 2, inducible	Mus musculus	137-141
23413029-1	2013	Prolyl hydroxylase domain protein 2 (PHD2, also known as Egg Laying Defective Nine homolog 1) is a key oxygen-sensing protein in metazoans.	Oxygen	103-109	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
23398456-2	2013	Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
23401619-1	2013	Studies of regulation of the haematopoietic growth factor erythropoietin led to the unexpected discovery of a widespread system of direct oxygen sensing that regulates gene expression in animals.	Oxygen	138-144	erythropoietin	Homo sapiens	58-72
23566437-3	2013	Hypoxia inducible factor-1alpha (HIF-1alpha), a key mediator of cellular adaptation to low oxygen levels, is emerging as a novel prognostic marker in breast cancer.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23566437-3	2013	Hypoxia inducible factor-1alpha (HIF-1alpha), a key mediator of cellular adaptation to low oxygen levels, is emerging as a novel prognostic marker in breast cancer.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23616771-5	2013	Tafazzin-knockdown in mice markedly impaired oxygen consumption rates during an exercise, without any significant effect on resting metabolic rates.	Oxygen	45-51	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	0-8
23418090-6	2013	Levels of the oxygen-sensitive HIF-1alpha subunit and expression of HIF target genes were increased in both hypoxic cells and cells treated with ET-1.	Oxygen	14-20	endothelin 1	Rattus norvegicus	145-149
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	endothelin 1	Rattus norvegicus	17-21
23413029-1	2013	Prolyl hydroxylase domain protein 2 (PHD2, also known as Egg Laying Defective Nine homolog 1) is a key oxygen-sensing protein in metazoans.	Oxygen	103-109	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
23413029-2	2013	In an oxygen-dependent manner, PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypoxic response, hypoxia-inducible factor-alpha (HIF-alpha), thereby targeting HIF-alpha for degradation.	Oxygen	6-12	egl-9 family hypoxia inducible factor 1	Homo sapiens	31-35
23347696-0	2013	Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.	Oxygen	80-86	arginine vasopressin receptor 2	Rattus norvegicus	22-45
23347696-1	2013	AIM: In the present study, we aimed to elucidate the effects of chronic vasopressin administration on renal medullary oxygen levels.	Oxygen	118-124	arginine vasopressin	Rattus norvegicus	72-83
23395155-5	2013	In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting eNOS to a superoxide-producing enzyme.	Oxygen	19-25	nitric oxide synthase 3	Homo sapiens	84-88
23545994-6	2013	A significant decrease in oxygen consumption (VO2) was observed after surgery, from 1,719 +- 571 to 1609 +- 428 mL min-1, p = 0.036.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
23713537-6	2013	Training-induced enhancement of insulin sensitivity (clamp) correlated with higher peak oxygen uptake (r = 0.70; p &lt; 0.05), but was independent of glucose kinetic and substrate metabolism.	Oxygen	88-94	insulin	Homo sapiens	32-39
23130672-2	2013	EGLN1, being an actual oxygen sensor, appears to have a potential role in the functional adaptation to the hypobaric hypoxic environment.	Oxygen	23-29	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-5
23380539-2	2013	Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor alpha (HIF-alpha) for von Hippel-Lindau protein-mediated proteasomal destruction.	Oxygen	104-110	egl-9 family hypoxia inducible factor 1	Homo sapiens	51-55
24194964-1	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
24194964-1	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
24194964-1	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
23340020-2	2013	In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and glucose deprivation (OGD).	Oxygen	208-214	vasoactive intestinal peptide	Rattus norvegicus	93-96
23596488-7	2013	The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure.	Oxygen	104-106	fibrinogen beta chain	Homo sapiens	23-26
22350022-3	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor for more than 60 genes recognized to control the delivery of oxygen and nutrients through the induction of angiogenesis and glycolysis under hypoxic conditions.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23830406-0	2013	Angiotensin II inhibits ADH-stimulated cAMP: role on O2- and transport-related oxygen consumption in the loop of Henle.	Oxygen	53-55	angiotensinogen	Rattus norvegicus	0-14
23830406-0	2013	Angiotensin II inhibits ADH-stimulated cAMP: role on O2- and transport-related oxygen consumption in the loop of Henle.	Oxygen	79-85	angiotensinogen	Rattus norvegicus	0-14
23830406-14	2013	The O2- scavenger tempol blocked the late Ang II effects on QO2, while Ang II increased O2- production during this period.	Oxygen	4-6	angiotensinogen	Rattus norvegicus	42-48
23830406-15	2013	We conclude that 1) Ang II has a transient effect on ADH-stimulated transport; 2) this effect is mediated by AT1 receptors; 3) the initial period is mediated by decreased cAMP and 4) the late period is mediated by O2-.	Oxygen	214-216	angiotensinogen	Rattus norvegicus	20-26
23286299-9	2013	In addition, SHIP2-Tg showed increased food consumption after starvation and become heavier with visceral fat accumulation than wild-type mice, despite normal levels of oxygen consumption and spontaneous movement.	Oxygen	169-175	inositol polyphosphate phosphatase-like 1	Mus musculus	13-21
23584321-6	2013	The best regression model to calculate the O2 consumption (VO2) was: VO2 (L min-1) =-1.264+0.026 bw (kg)+0.195 VD (m).	Oxygen	43-45	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
23379999-1	2013	Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF).	Oxygen	28-34	succinate receptor 1	Rattus norvegicus	87-116
23379999-1	2013	Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF).	Oxygen	28-34	succinate receptor 1	Rattus norvegicus	118-123
22350022-3	2013	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor for more than 60 genes recognized to control the delivery of oxygen and nutrients through the induction of angiogenesis and glycolysis under hypoxic conditions.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23097160-1	2013	Hypoxia inducible factor 1alpha (HIF-1alpha), an essential transcriptional factor, is negatively regulated by two different types of oxygen and Fe(2+) -dependent HIF hydroxylases, proline hydroxylase (PHD) and factor inhibiting HIF (FIH), under normoxia.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
23097160-1	2013	Hypoxia inducible factor 1alpha (HIF-1alpha), an essential transcriptional factor, is negatively regulated by two different types of oxygen and Fe(2+) -dependent HIF hydroxylases, proline hydroxylase (PHD) and factor inhibiting HIF (FIH), under normoxia.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
23142737-3	2013	The aim of this study was to determine whether human erythropoietin (rhEPO) reduces the astrocytic swelling created by oxygen-glucose deprivation followed by reoxygenation (OGD/Reox) in vitro and whether this effect can be mediated through the modulation of aquaporin4 (AQP4) expression in the plasma membrane (PM) and phosphorylation of the mitogen-activated protein kinase pathway (MAPK) pathway.	Oxygen	119-125	erythropoietin	Homo sapiens	53-67
23599780-2	2013	Expression of the HIF-1alpha subunit is responsive to changes in oxygen levels.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
26105901-9	2013	The partial pressure of oxygen (PaO2) in umbilical arterial blood tended to be lower in preeclamptic women with FGR (p=0.08).	Oxygen	24-30	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
23352974-11	2013	Carbogen (95% O2 plus 5% CO2) treatment increased the ratio of p-Smad2/t-Smad2, which was inhibited by 10006329 EUK (EUK134) and sodium nitroprusside (SNP).	Oxygen	14-16	SMAD family member 2	Mus musculus	65-70
23352974-11	2013	Carbogen (95% O2 plus 5% CO2) treatment increased the ratio of p-Smad2/t-Smad2, which was inhibited by 10006329 EUK (EUK134) and sodium nitroprusside (SNP).	Oxygen	14-16	SMAD family member 2	Mus musculus	73-78
23448368-3	2013	Under normoxia, the oxygen-sensitive alpha subunit of HIF1 is rapidly and constitutively degraded but is stabilized and accumulates under hypoxia.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-58
23292809-1	2013	We and others have shown that epithelial Na(+) channels (ENaC) in alveolar type 2 (AT2) cells are activated by beta2 agonists, steroid hormones, elevated oxygen tension, and by dopamine.	Oxygen	154-160	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	30-55
23292809-1	2013	We and others have shown that epithelial Na(+) channels (ENaC) in alveolar type 2 (AT2) cells are activated by beta2 agonists, steroid hormones, elevated oxygen tension, and by dopamine.	Oxygen	154-160	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	57-61
23348729-4	2013	One gene previously known to be important in cellular oxygen sensing, egl nine homolog 1 (EGLN1), shows evidence of positive selection in both Tibetans and Andeans.	Oxygen	54-60	egl-9 family hypoxia inducible factor 1	Homo sapiens	70-88
23337360-0	2013	Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.	Oxygen	60-66	aryl-hydrocarbon receptor	Mus musculus	25-50
23351038-2	2013	Oxygen homeostasis is set by the hypoxia inducible factor-1alpha (HIF-1alpha) pathway, which is controlled by factor inhibiting HIF-1alpha (FIH).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-64
23351038-2	2013	Oxygen homeostasis is set by the hypoxia inducible factor-1alpha (HIF-1alpha) pathway, which is controlled by factor inhibiting HIF-1alpha (FIH).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
23351038-2	2013	Oxygen homeostasis is set by the hypoxia inducible factor-1alpha (HIF-1alpha) pathway, which is controlled by factor inhibiting HIF-1alpha (FIH).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
23348729-4	2013	One gene previously known to be important in cellular oxygen sensing, egl nine homolog 1 (EGLN1), shows evidence of positive selection in both Tibetans and Andeans.	Oxygen	54-60	egl-9 family hypoxia inducible factor 1	Homo sapiens	90-95
23201478-7	2013	Analysis of oxygen uptake by isolated mitochondria showed that complex I and external NADH dehydrogenase activities were inhibited in GSNOR(OE) cells grown under nutritional stress.	Oxygen	12-18	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	134-139
23281060-4	2013	OGD induced a retarded and sustained increase in extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after restoring glucose and O(2) (reperfusion-like conditions).	Oxygen	144-148	mitogen-activated protein kinase 1	Homo sapiens	49-90
23160832-3	2013	Neuroglobin and cytoglobin have been suggested as novel therapeutic targets in various neurodegenerative diseases based on their oxygen binding and cell protecting properties.	Oxygen	129-135	cytoglobin	Homo sapiens	16-26
22977222-10	2013	We conclude that increased ambient oxygen concentration after birth drives maturation of the cardiac electrical conduction system, failure of which leads to aberrant ion channel and Connexin43 expression and predisposes to arrhythmia and sudden death.	Oxygen	35-41	gap junction protein, alpha 1	Mus musculus	182-192
23297826-0	2013	Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
23297826-0	2013	Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer.	Oxygen	0-6	AKT serine/threonine kinase 1	Homo sapiens	66-69
23297826-0	2013	Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer.	Oxygen	0-6	mechanistic target of rapamycin kinase	Homo sapiens	70-74
23297826-1	2013	Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a transcription factor which is central component of oxygen sensing mechanism in mammalian cells.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-83
23297826-1	2013	Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a transcription factor which is central component of oxygen sensing mechanism in mammalian cells.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-90
23297826-3	2013	Thus, HIF-1 claimed the role of the master that orchestrates cellular responses to oxygen deprivation.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	6-11
23297826-4	2013	In addition, HIF-1 is also activated or influenced through oxygen-independent mechanisms via growth factors, deregulated oncogenes, and/or tumor suppressors.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-18
23341197-4	2013	Exposure of primary isolated trophoblasts to 3% O(2) resulted in elevated Par6 expression, maintenance of tight junction marker ZO-1 at cell boundaries, and decreased fusogenic syncytin 1 expression compared with cells cultured at 20% O(2).	Oxygen	48-52	tight junction protein 1	Homo sapiens	128-132
23341197-4	2013	Exposure of primary isolated trophoblasts to 3% O(2) resulted in elevated Par6 expression, maintenance of tight junction marker ZO-1 at cell boundaries, and decreased fusogenic syncytin 1 expression compared with cells cultured at 20% O(2).	Oxygen	48-52	endogenous retrovirus group W member 1, envelope	Homo sapiens	177-187
23281060-4	2013	OGD induced a retarded and sustained increase in extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after restoring glucose and O(2) (reperfusion-like conditions).	Oxygen	144-148	mitogen-activated protein kinase 3	Homo sapiens	92-98
22382653-8	2013	Fractalkine were associated with AHI (r = 0.756, P &lt; 0.0001), lowest oxygen saturation (r = -0.466, P = 0.005), and mean oxygen saturation (r = -0.344, P = 0.043).	Oxygen	72-78	C-X3-C motif chemokine ligand 1	Homo sapiens	0-11
23299244-0	2013	SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.	Oxygen	26-32	sirtuin 1	Rattus norvegicus	0-5
22991091-2	2013	We investigated the effect of hyperbaric oxygen (HBO) on (1) interleukin-1beta (IL-1beta)-induced NO production and apoptosis of rabbit chondrocytes and (2) healing of articular cartilage defects.	Oxygen	41-47	interleukin-1 beta	Oryctolagus cuniculus	61-78
22991091-2	2013	We investigated the effect of hyperbaric oxygen (HBO) on (1) interleukin-1beta (IL-1beta)-induced NO production and apoptosis of rabbit chondrocytes and (2) healing of articular cartilage defects.	Oxygen	41-47	interleukin-1 beta	Oryctolagus cuniculus	80-88
23059865-6	2013	In STG, V O2max increased (P &lt; 0.01) from 32.6 +- 4.9 to 35.4 +- 6.6 mL min-1 kg-1 and relative V O2 during cycling at 100 W was lowered (P &lt; 0.05) from 55% +- 7% to 50% +- 8% V O2max over 6 months, with no changes in DAG.	Oxygen	10-12	CD59 molecule (CD59 blood group)	Homo sapiens	75-85
23060043-0	2013	Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension.	Oxygen	139-145	fibroblast growth factor 2	Homo sapiens	10-36
23266676-5	2013	By embedding [Cu(DPPZ)(PPh(3))(2)]BF(4) into a polymer supporting matrix of polystyrene, the emission signal is found to be sensitive towards varying oxygen concentrations, with a maximum sensitivity of 3.78.	Oxygen	150-156	caveolin 1	Homo sapiens	23-29
23266676-6	2013	We attribute this sensitivity to the large conjugation plane in DPPZ ligand which can increase the population of excited state electrons and favor the oxygen attack on [Cu(DPPZ)(PPh(3))(2)]BF(4) excited state.	Oxygen	151-157	caveolin 1	Homo sapiens	178-184
22382653-8	2013	Fractalkine were associated with AHI (r = 0.756, P &lt; 0.0001), lowest oxygen saturation (r = -0.466, P = 0.005), and mean oxygen saturation (r = -0.344, P = 0.043).	Oxygen	124-130	C-X3-C motif chemokine ligand 1	Homo sapiens	0-11
23110349-5	2013	Oxygen ingress through the closure postbottling was positively correlated with the decrease of SPI.	Oxygen	0-6	chromogranin A	Homo sapiens	95-98
23281937-5	2013	The changes observed in the chemical shifts of (31)P MAS NMR spectra with x are found to be too large to be caused solely by changing sodium modification of the phosphate SRO structural groups, and this indicates that internetwork bonding between phosphorus and boron through bridging oxygens (BOs), P-O-B, must be a major contributor to the IRO structure of these glasses.	Oxygen	285-292	ER membrane protein complex subunit 3	Homo sapiens	300-305
23293030-5	2013	Cytoplasmic extracts of MCF-7 cells grown under hypoxia (1% oxygen) recapitulate VEGF IRES-mediated reporter mRNA translation.	Oxygen	60-66	vascular endothelial growth factor A	Homo sapiens	81-85
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	Oxygen	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23239109-0	2013	Sp2 C-dominant N-doped carbon sub-micrometer spheres with a tunable size: a versatile platform for highly efficient oxygen-reduction catalysts.	Oxygen	116-122	Sp2 transcription factor	Homo sapiens	0-3
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Oxygen	178-184	amyloid beta precursor protein	Homo sapiens	77-82
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	Oxygen	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-163
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Oxygen	178-184	amyloid beta precursor protein	Homo sapiens	63-75
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-54
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Oxygen	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-185
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Oxygen	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
23343346-6	2013	Such a positive shift of [Co(III)(Ch)](+) by protonation resulted in enhancement of the catalytic reactivity of [Co(III)(ChH)](2+) for the two-electron reduction of O(2) with a lower overpotential as compared with that of [Co(III)(OEP)](+).	Oxygen	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-234
23220721-0	2013	Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors.	Oxygen	38-44	cannabinoid receptor 1	Homo sapiens	92-95
23347056-0	2013	Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties.	Oxygen	190-196	catalase	Rattus norvegicus	151-159
23125284-1	2013	The mitochondrial respiratory chain complex IV (cytochrome c oxidase) is a multi-subunit enzyme that transfers electrons from cytochrome c to molecular oxygen, yielding water.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	48-60
23125284-1	2013	The mitochondrial respiratory chain complex IV (cytochrome c oxidase) is a multi-subunit enzyme that transfers electrons from cytochrome c to molecular oxygen, yielding water.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	126-138
23348708-7	2013	Taken together, these results suggest that the ERK-mediated Ser phosphorylation of p47(phox) is not implicated in the assembly of NADPH oxidase or O2( -) generation, and that O2( -) generation is partly attributable to p38 MAPK signaling through mechanisms other than p47(phox) activation, Akt activation and S100A9 membrane recruitment in fMLP-stimulated neutrophils.	Oxygen	175-177	mitogen-activated protein kinase 1	Homo sapiens	47-50
23241411-3	2013	The goal of this study is to determine the role of TLR4 signaling in oxygen-induced neovascularization in retina, a neural tissue.	Oxygen	69-75	toll-like receptor 4	Mus musculus	51-55
23241411-4	2013	METHODS AND RESULTS: In oxygen-induced retinopathy model, we found that retinal neovascularization was significantly attenuated in TLR4(-/-) mice.	Oxygen	24-30	toll-like receptor 4	Mus musculus	131-135
23242184-11	2013	This effect is mediated by suppression of EPO 3"-enhancer activity via ATF4 without any direct effect on HIF, indicating that UPR contributes to oxygen-sensing regulation of EPO.	Oxygen	145-151	activating transcription factor 4	Rattus norvegicus	71-75
23333395-6	2013	IL-8 production was significantly induced in 1% O(2), with 5.5 mM glucose (p&lt;0.01).	Oxygen	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23259733-7	2013	When the oxygen concentration was lower than 22 muM and under the presence of 150 nM H(2)O(2), the model showed that the oxidation of Cu(I) was controlled by its reaction with H(2)O(2).	Oxygen	9-15	latexin	Homo sapiens	48-51
23314690-6	2013	Hypermethylation with low oxygen tension was independently confirmed by bisulfite-pyrosequencing in a subset of functionally relevant genes including CD59, CFB, GRAM3 and ZNF217.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	150-154
23168532-0	2013	Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.	Oxygen	0-6	carbonic anhydrase 3	Homo sapiens	92-95
23117226-0	2013	Analytical expressions for the steady-state concentrations of glucose, oxygen and gluconic acid in a composite membrane for closed-loop insulin delivery.	Oxygen	71-77	insulin	Homo sapiens	136-143
23277191-2	2013	It provides an oxygen sparing effect in the myocardium by creating a switch from fatty acid to glucose metabolism through partial inhibition of carnitine palmitoyltransferase 1 and 2.	Oxygen	15-21	carnitine palmitoyltransferase 2	Mus musculus	144-182
23022047-9	2013	DRG neurons derived from STZ-diabetic mice also exhibited deficiencies in maximal oxygen consumption rate and associated spare respiratory capacity that were corrected by exposure to CNTF for 24 h in an NF-kappaB-dependent manner.	Oxygen	82-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	203-212
23303788-0	2013	Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.	Oxygen	0-6	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	117-121
23303788-6	2013	We demonstrate that RBPJ and CHCHD2 function towards activating the ORE at 4% oxygen, whereas CXXC5 functions as an inhibitor.	Oxygen	78-84	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	20-24
22886767-0	2013	Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells.	Oxygen	11-17	mitogen-activated protein kinase 3	Homo sapiens	39-43
23631138-5	2013	Compared with the data before surgery, oxygen saturation of blood in children of treatment group recorded by PSG increased (P&lt;0.05), while value of other data decreased (P&lt;0.05).	Oxygen	39-45	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	109-112
22987685-1	2013	Hemoglobin (Hb), an oxygen-binding protein composed of four subunits (alpha1, alpha2, beta1, and beta2), is a well-known example of allosteric proteins that are capable of cooperative ligand binding.	Oxygen	20-26	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	86-91
23011899-1	2013	The von Hippel-Lindau tumor suppressor protein (pVHL) plays a central role in the oxygen-sensing pathway by regulating the degradation of the hypoxia-inducible factor (HIF-1alpha).	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-178
23299479-2	2013	Previous studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membrane-anchored metalloproteinase that regulates epidermal growth factor receptor (EGFR) signaling, reduces pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	266-272	a disintegrin and metallopeptidase domain 17	Mus musculus	45-83
23011899-2	2013	The capture of HIF-1alpha by pVHL is regulated by an oxygen-dependent hydroxylation of a specific conserved prolyl residue.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
23143058-12	2013	Low-dose ET-1 infusion caused an increase in hepatic O(2)consumption, whereas low-dose ET-1 infusion decreased O(2) consumption in endotoxemic livers.	Oxygen	53-57	endothelin 1	Rattus norvegicus	9-13
23143058-12	2013	Low-dose ET-1 infusion caused an increase in hepatic O(2)consumption, whereas low-dose ET-1 infusion decreased O(2) consumption in endotoxemic livers.	Oxygen	111-115	endothelin 1	Rattus norvegicus	87-91
23299479-2	2013	Previous studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membrane-anchored metalloproteinase that regulates epidermal growth factor receptor (EGFR) signaling, reduces pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	266-272	a disintegrin and metallopeptidase domain 17	Mus musculus	85-91
23386854-6	2013	The Photosystem II oxygen-evolving complex protein PsbO interaction with TGB3 is presumed to have a crucial role in symptom development and lethal damage under dark conditions.	Oxygen	19-25	triple gene block 3 protein 7k	Alternanthera mosaic virus	73-77
23294126-3	2013	When the oxygen deintercalated from the "MnO(2)" equatorial layers of the structure results in the Sr(2)MnO(3.69(2)) composition, the RP phase undergoes a first order I4/mmm   P2(1)/c, tetragonal to monoclinic phase transition as observed from time-resolved in situ NPD.	Oxygen	9-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-183
23229554-1	2013	Oxygen deprivation is accompanied by the coordinated expression of numerous hypoxia-responsive genes, many of which are controlled by hypoxia-inducible factor-1 (HIF-1).	Oxygen	0-6	Hypoxia-inducible factor 1	Caenorhabditis elegans	134-160
23229554-1	2013	Oxygen deprivation is accompanied by the coordinated expression of numerous hypoxia-responsive genes, many of which are controlled by hypoxia-inducible factor-1 (HIF-1).	Oxygen	0-6	Hypoxia-inducible factor 1	Caenorhabditis elegans	162-167
23188724-1	2013	PURPOSE: To determine the function of tumor necrosis factor receptor-2 (TNFR2) in retinal development and ischemia-induced revascularization in an oxygen-induced retinopathy (OIR) model.	Oxygen	147-153	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	38-70
23332757-0	2013	SOD1 integrates signals from oxygen and glucose to repress respiration.	Oxygen	29-35	superoxide dismutase 1	Homo sapiens	0-4
23104692-12	2013	In addition to maintaining the activity of mitochondrial respiratory chain complexes and possibly decreasing apoptosis, pretreatment with BNP protects skeletal muscle against IR-induced lesions, most likely by decreasing excessive production of radical oxygen species and opening mK(ATP) channels.	Oxygen	253-259	natriuretic peptide B	Rattus norvegicus	138-141
24216696-1	2013	Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
24216696-1	2013	Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
23332757-6	2013	Therefore, in a single circuit, oxygen, glucose, and reactive oxygen can repress respiration through SOD1/CK1gamma signaling.	Oxygen	32-38	superoxide dismutase 1	Homo sapiens	101-105
23332757-6	2013	Therefore, in a single circuit, oxygen, glucose, and reactive oxygen can repress respiration through SOD1/CK1gamma signaling.	Oxygen	62-68	superoxide dismutase 1	Homo sapiens	101-105
24024154-5	2013	Using soluble guanylyl cyclase (sGC) and p53 as model  NO-sensitive proteins, we demonstrate that their concentration-dependent responses to  NO are a function of the O2 concentration.	Oxygen	167-169	tumor protein p53	Homo sapiens	41-44
24024154-9	2013	Enzymatic  NO production, however, requires O2 as a substrate such that decreasing the O2 concentration below the K m for O2 for nitric oxide synthase (NOS) will decrease the production of  NO.	Oxygen	44-46	nitric oxide synthase 2	Homo sapiens	129-150
24024154-9	2013	Enzymatic  NO production, however, requires O2 as a substrate such that decreasing the O2 concentration below the K m for O2 for nitric oxide synthase (NOS) will decrease the production of  NO.	Oxygen	87-89	nitric oxide synthase 2	Homo sapiens	129-150
24024154-9	2013	Enzymatic  NO production, however, requires O2 as a substrate such that decreasing the O2 concentration below the K m for O2 for nitric oxide synthase (NOS) will decrease the production of  NO.	Oxygen	87-89	nitric oxide synthase 2	Homo sapiens	129-150
24024135-1	2013	Superoxide dismutase (EC-SOD) controls the level of superoxide in the extracellular space by catalyzing the dismutation of superoxide into hydrogen peroxide and molecular oxygen.	Oxygen	171-177	superoxide dismutase 3	Homo sapiens	22-28
23188724-1	2013	PURPOSE: To determine the function of tumor necrosis factor receptor-2 (TNFR2) in retinal development and ischemia-induced revascularization in an oxygen-induced retinopathy (OIR) model.	Oxygen	147-153	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	72-77
22836639-0	2013	Development and aging are oxygen-dependent and correlate with VEGF and NOS along life span.	Oxygen	26-32	vascular endothelial growth factor A	Homo sapiens	62-66
24307995-2	2013	Based on our previous work that coadministration of tissue factor and lipopolysaccharide following radiosurgery selectively induced thrombosis in cerebral arteriovenous malformations, achieving thrombosis of 69% of the capillaries and 39% of medium sized vessels, we hypothesized that a rapid and selective shutdown of the capillaries in glioblastoma vasculature would decrease the delivery of oxygen and nutrients, reducing tumor growth, preventing intracranial hypertension, and improving life expectancy.	Oxygen	394-400	coagulation factor III	Mus musculus	52-65
23224890-5	2013	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	solute carrier family 8 member A1	Homo sapiens	28-32
23224890-5	2013	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	solute carrier family 8 member A3	Homo sapiens	157-161
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	Oxygen	78-84	glutathione S-transferase mu 1	Homo sapiens	121-126
23509738-0	2013	Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels.	Oxygen	25-31	CD34 molecule	Homo sapiens	62-66
23762985-2	2013	Simvastatin at a concentration of 100 ng/ml increases p50 (the blood pO2 corresponding to its 50% oxygen saturation) at real values of pH and pCO2 from 39.53 + 2.41 (p &lt;0.05) to 36.60 (36, 40, 37, 60) (p &lt;0.05) mm Hg.	Oxygen	98-104	nuclear factor kappa B subunit 1	Homo sapiens	54-57
23138570-1	2013	Induction of HIF-1alpha by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
23138570-1	2013	Induction of HIF-1alpha by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells.	Oxygen	27-33	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	146-149
23712868-7	2013	Expression of the HIF-1alpha oxygen-dependent degradation domain mutant in cells resulted in elevated AGR2 levels and an increased ability to induce HUVEC migration and tube formation in vitro and enhanced growth and vascularity of tumor xenografts in vivo, which were prevented by AGR2 knockdown.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
23336598-4	2013	We then determined by Western blots the effects of cell-free media from hypoxic-conditioned HUCBCs (HUCM) on activation of the cell survival protein Akt in human coronary artery endothelial cells and cardiac myocytes in culture during 24 h of 1% O2.	Oxygen	246-248	AKT serine/threonine kinase 1	Homo sapiens	149-152
23336598-8	2013	HUCM, which contained these biological factors, significantly increased Akt phosphorylation/activation in coronary artery endothelial cells and cardiac myocytes subjected to 24 h of 1% O2 by more than 60% (p&lt;0.05) and increased the antiapoptotic protein Bcl-2 expression by 34-50% in comparison with endothelial cells and myocytes treated without HUCM in 1% O2(p&lt;0.05).	Oxygen	185-187	AKT serine/threonine kinase 1	Homo sapiens	72-75
22973959-4	2013	Considering the effects of EGFR-targeting agents under reduced oxygen conditions, it is now accepted that, together with their demonstrated antiproliferative and proapoptotic effects, the antiangiogenic activity of these drugs also contributes to their overall antitumor activity in vivo.	Oxygen	63-69	epidermal growth factor receptor	Homo sapiens	27-31
22523355-2	2013	The Src family tyrosine kinase (SrcTK) may control potassium channel function in human pulmonary artery smooth muscle cells (hPASMCs) in response to changes in oxygen tension and the clinical use of a SrcTK inhibitor has resulted in partly reversible pulmonary hypertension.	Oxygen	160-166	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
23165748-9	2013	In conclusion,             TSA inhibited the growth of HeLa cells via Bcl-2-mediated apoptosis, which was             closely related to O2 - and GSH content levels.	Oxygen	137-139	BCL2 apoptosis regulator	Homo sapiens	70-75
23024006-8	2013	Higher hs-cTnT levels were also associated with the presence of pathological q-waves (p=0.012) and electrocardiographic left ventricular hypertrophy (p=0.039), long-term oxygen treatment (p=0.002) and decreasing forced expiratory volume in 1 s (p=0.014).	Oxygen	170-176	troponin T2, cardiac type	Homo sapiens	10-14
24001722-4	2013	In X. laevis Gln38alpha is unable to form a hydrogen bond with beta97His or beta99Asp, which is responsible for the increase in oxygen affinity of the Xenopus HbA1.	Oxygen	128-134	Hemoglobin subunit alpha-1	Xenopus laevis	159-163
24001722-6	2013	Hence it is predicted that the HbA1 component of X. laevis has higher oxygen affinity.	Oxygen	70-76	Hemoglobin subunit alpha-1	Xenopus laevis	31-35
23135723-4	2013	In cells, the mammalian target of rapamycin (mTOR) regulates the activity of host cap-dependent translation by integrating amino acid, energy, and oxygen availability signals.	Oxygen	147-153	mechanistic target of rapamycin kinase	Homo sapiens	14-43
23671876-0	2013	IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers.	Oxygen	32-38	insulin like growth factor 1	Homo sapiens	0-5
23671876-2	2013	To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers.	Oxygen	85-91	insulin like growth factor 1	Homo sapiens	15-43
23671876-2	2013	To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers.	Oxygen	85-91	insulin like growth factor 1	Homo sapiens	45-50
23082872-10	2013	Intetumumab significantly decreased VEGF levels in DAOY cells at both oxygen conditions (p &lt; 0.05) and in normoxic D283 cells (p &lt; 0.01).	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	36-40
24846908-2	2013	When in excess, both pyruvate and lactate can increase the stabilization of the hypoxia-inducible factor 1-alpha (HIF-1alpha) transcription factor, resulting in the trans-activation of HIF-1alpha regulated genes independent of low oxygen, termed pseudo-hypoxia.	Oxygen	231-237	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-112
24846908-2	2013	When in excess, both pyruvate and lactate can increase the stabilization of the hypoxia-inducible factor 1-alpha (HIF-1alpha) transcription factor, resulting in the trans-activation of HIF-1alpha regulated genes independent of low oxygen, termed pseudo-hypoxia.	Oxygen	231-237	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
22644539-10	2013	Furthermore, increased TH homo-specific activity leading to an increase in DA may cause toxic reactive oxygen species in the neurons to promote neurodegeneration.	Oxygen	103-109	tyrosine hydroxylase	Homo sapiens	23-25
23348535-11	2013	IL-6 level correlated negatively with peak oxygen consumption (r = -0.25, p = 0.035) and the IPAQ-SF score (r = -0.26, p = 0.02), and sCD40L level correlated negatively with the IPAQ-SF score (r = -0.4, p = 0.004).	Oxygen	43-49	interleukin 6	Homo sapiens	0-4
23879047-0	2013	[The influence of amlodipine on transcapillary metabolism of oxygen during coronary heart disease with insulin resistance].	Oxygen	61-67	insulin	Homo sapiens	103-110
24577260-12	2013	CONCLUSIONS: Overexpression of the VEGF gene in subjects with DPE&gt;3,5 g may point to insufficient oxygen supply in renal tissue which may result in tubulointerstitial fibrosis with further functional renal impairment and decline of eGFR.	Oxygen	101-107	vascular endothelial growth factor A	Homo sapiens	35-39
23135723-4	2013	In cells, the mammalian target of rapamycin (mTOR) regulates the activity of host cap-dependent translation by integrating amino acid, energy, and oxygen availability signals.	Oxygen	147-153	mechanistic target of rapamycin kinase	Homo sapiens	45-49
23335846-6	2013	Furthermore, we demonstrate a link between sustained VEGF expression and the ability of the hypoxic human lens epithelial cell to thrive in low oxygen conditions and resist mitochondrial membrane permeability transition (also referred to as lenticular cytoprotection).	Oxygen	144-150	vascular endothelial growth factor A	Homo sapiens	53-57
23335846-12	2013	RESULTS: Cultured human lens epithelial cells (HLE-B3) maintained under hypoxic condition (1% oxygen) displayed consistent accumulation of VEGF throughout the 72 h incubation period.	Oxygen	94-100	vascular endothelial growth factor A	Homo sapiens	139-143
23401655-15	2013	The results suggest that PSSG and PSSC formation may act to delay O(2)-induced insolubilization of gammaA-, gammaB-, and gammaC-crystallins, and beta-crystallins, but with a greater effect on the gamma-crystallins at an early stage of oxidative stress.	Oxygen	66-70	phosphatidylserine decarboxylase	Homo sapiens	34-38
23401655-15	2013	The results suggest that PSSG and PSSC formation may act to delay O(2)-induced insolubilization of gammaA-, gammaB-, and gammaC-crystallins, and beta-crystallins, but with a greater effect on the gamma-crystallins at an early stage of oxidative stress.	Oxygen	66-70	gamma-crystallin B	Cavia porcellus	99-139
23983903-6	2013	for 7 days significantly suppressed the microglial expression of IL-1beta, TNF-alpha, IL-6, and 8-oxo-deoxyguanosine, a biomarker for oxidative damaged DNA, in the somatosensory cortex of mice subjected to hypoxia exposure (10% O2, 4 h).	Oxygen	228-230	interleukin 1 beta	Mus musculus	65-73
23711562-8	2013	In multivariable analysis controlling for postnatal age, lower VEGF/protein was associated with higher levels of mechanical respiratory support (p = 0.006), male gender (p = 0.001) and early sepsis (p = 0.003) but not with fraction of inspired oxygen.	Oxygen	244-250	vascular endothelial growth factor A	Homo sapiens	63-67
23738044-1	2013	Nrf2 protects the lung from adverse responses to oxidants, including 100% oxygen (hyperoxia) and airborne pollutants like particulate matter (PM) exposure, but the role of Nrf2 on heart rate (HR) and heart rate variability (HRV) responses is not known.	Oxygen	74-80	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
23418527-1	2013	UNLABELLED: Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hb(mass)) and maximal oxygen uptake (v O(2 max)).	Oxygen	104-110	erythropoietin	Homo sapiens	30-44
23382692-1	2013	Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway.	Oxygen	4-10	similar	Drosophila melanogaster	175-199
23382692-1	2013	Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway.	Oxygen	4-10	similar	Drosophila melanogaster	201-204
23459416-6	2013	This tracheogenic phenotype shows a genetic dependence on sima, which encodes the HIF-1alpha subunit of the hypoxia-inducible transcription factor dHIF and its target the FGF ligand branchless (bnl), and is enhanced by depletion of the Drosophila Von Hippel Lindau (dVHL) factor, which is a subunit of an oxygen-dependent ubiquitin ligase that degrades Sima/HIF-1alpha protein in metazoan cells.	Oxygen	305-311	similar	Drosophila melanogaster	58-62
23459416-6	2013	This tracheogenic phenotype shows a genetic dependence on sima, which encodes the HIF-1alpha subunit of the hypoxia-inducible transcription factor dHIF and its target the FGF ligand branchless (bnl), and is enhanced by depletion of the Drosophila Von Hippel Lindau (dVHL) factor, which is a subunit of an oxygen-dependent ubiquitin ligase that degrades Sima/HIF-1alpha protein in metazoan cells.	Oxygen	305-311	similar	Drosophila melanogaster	82-92
23516428-2	2013	We currently evaluated the significance of miR-29c, a highly expressed miRNA in rodent brain that was significantly down-regulated after focal ischemia in adult rats as well as after oxygen-glucose deprivation in PC12 cells.	Oxygen	183-189	microRNA 29c	Rattus norvegicus	43-50
23457492-1	2013	Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms.	Oxygen	111-117	catalase	Homo sapiens	0-8
23342124-6	2013	During neural differentiation, 3% O2 treatment increases the expression of HIF-1alpha, phosphorylated ERK and p38 MAPK.	Oxygen	34-36	Eph receptor B1	Rattus norvegicus	102-105
23372771-8	2013	We propose that the changing oxygen environment at birth acts as a physiologic signal to induce lung Klf4 mRNA expression, which then regulates proliferation and apoptosis in fibroblasts and airway epithelial cells, and connective tissue gene expression and myofibroblast differentiation at the tips of developing alveoli.	Oxygen	29-35	Kruppel-like factor 4 (gut)	Mus musculus	101-105
23662182-9	2013	This study also underscores the importance of PLD signaling in vascular leak and associated tissue injury in the etiology of lung diseases among critically ill patients encountering oxygen toxicity and excess ROS production during ventilator-assisted breathing.	Oxygen	182-188	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
23355903-0	2013	Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line.	Oxygen	0-6	GLI family zinc finger 2	Homo sapiens	97-102
23355903-5	2013	However, decreasing the oxygen tension to 5% O2 significantly increased the rate of phorbol ester-induced differentiation of THP-1 cells into macrophage-like cells as well as the metabolic activity of both undifferentiated and PMA-differentiated THP-1 cells.	Oxygen	24-30	GLI family zinc finger 2	Homo sapiens	125-130
23355903-5	2013	However, decreasing the oxygen tension to 5% O2 significantly increased the rate of phorbol ester-induced differentiation of THP-1 cells into macrophage-like cells as well as the metabolic activity of both undifferentiated and PMA-differentiated THP-1 cells.	Oxygen	24-30	GLI family zinc finger 2	Homo sapiens	246-251
23355903-5	2013	However, decreasing the oxygen tension to 5% O2 significantly increased the rate of phorbol ester-induced differentiation of THP-1 cells into macrophage-like cells as well as the metabolic activity of both undifferentiated and PMA-differentiated THP-1 cells.	Oxygen	45-47	GLI family zinc finger 2	Homo sapiens	125-130
23355903-5	2013	However, decreasing the oxygen tension to 5% O2 significantly increased the rate of phorbol ester-induced differentiation of THP-1 cells into macrophage-like cells as well as the metabolic activity of both undifferentiated and PMA-differentiated THP-1 cells.	Oxygen	45-47	GLI family zinc finger 2	Homo sapiens	246-251
23355903-7	2013	In differentiated THP-1 cells, lowering the oxygen tension to 5% O2 decreased phagocytic activity, the constitutive release of beta-hexosaminidase and LPS-induced NF-kappaB activation but enhanced LPS-stimulated release of cytokines.	Oxygen	44-50	GLI family zinc finger 2	Homo sapiens	18-23
23355903-7	2013	In differentiated THP-1 cells, lowering the oxygen tension to 5% O2 decreased phagocytic activity, the constitutive release of beta-hexosaminidase and LPS-induced NF-kappaB activation but enhanced LPS-stimulated release of cytokines.	Oxygen	65-67	GLI family zinc finger 2	Homo sapiens	18-23
23355903-8	2013	Collectively, these data demonstrate that oxygen tension influences THP-1 cell differentiation and primary macrophage functions, and suggest that culturing these cells under tightly regulated oxygen tension in the absence of exogenous reducing agent and serum is likely to provide a physiologically relevant baseline from which to study the role of the local redox environment in regulating THP-1 cell physiology.	Oxygen	42-48	GLI family zinc finger 2	Homo sapiens	68-73
23742090-0	2013	Production, purification, and chemical stability of recombinant human interferon-gamma in low oxygen tension condition: a formulation approach.	Oxygen	94-100	interferon gamma	Homo sapiens	70-86
22902253-1	2013	Erythropoietin (Epo) was originally discovered as a cytokine able to increase the production of red blood cells upon conditions of reduced oxygen availability.	Oxygen	139-145	erythropoietin	Homo sapiens	0-14
24001324-10	2013	Oxygen pretreatment inhibited caspase 3 activation and decreased Bax/Bcl-2 ratio.	Oxygen	0-6	caspase 3	Homo sapiens	30-39
24001324-10	2013	Oxygen pretreatment inhibited caspase 3 activation and decreased Bax/Bcl-2 ratio.	Oxygen	0-6	BCL2 associated X, apoptosis regulator	Homo sapiens	65-68
24001324-10	2013	Oxygen pretreatment inhibited caspase 3 activation and decreased Bax/Bcl-2 ratio.	Oxygen	0-6	BCL2 apoptosis regulator	Homo sapiens	69-74
23372771-0	2013	Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation.	Oxygen	50-56	Kruppel-like factor 4 (gut)	Mus musculus	21-25
22902253-1	2013	Erythropoietin (Epo) was originally discovered as a cytokine able to increase the production of red blood cells upon conditions of reduced oxygen availability.	Oxygen	139-145	erythropoietin	Homo sapiens	16-19
22738377-8	2013	Culture of eMSC for 7 days on a fibronectin matrix in DMEM/SF/FGF2/EGF serum-free media in 5% O2 maintained greater numbers of undifferentiated eMSC expressing CD140b, CD146, and W5C5 compared to culture under similar conditions in Lonza TP-SF medium.	Oxygen	94-96	fibroblast growth factor 2	Homo sapiens	62-66
24135094-7	2013	Calculated average oxygen transfer rates (OTRs) increased proportionally with the influent load, and the OTR value was Vr &gt; V&gt; H. The relations of load-OTR, COD-ammonium, and a Arrhenius temperature-dependent equation enable the basic design of a reed bed system.	Oxygen	19-25	oxytocin receptor	Sus scrofa	42-45
23060442-4	2012	We show that hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity induced by VEGFA was inhibited by endorepellin independent of oxygen concentration and that only a combination of both PI3K and calcineurin inhibitors completely blocked the suppressive activity evoked by endorepellin on HIF1A and VEGFA promoter activity.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-44
22940127-1	2012	We report here the first examples of Polymer Therapeutics synthesised with the intention of inhibiting Hypoxia Inducible Factor-1 (HIF-1), a transcription factor heavily involved in numerous cell processes under a low oxygen environment.	Oxygen	218-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-129
22940127-1	2012	We report here the first examples of Polymer Therapeutics synthesised with the intention of inhibiting Hypoxia Inducible Factor-1 (HIF-1), a transcription factor heavily involved in numerous cell processes under a low oxygen environment.	Oxygen	218-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-136
23336160-9	2013	CONCLUSIONS: INSURE method can improve the oxygenation function of the lung, decrease the incidence of VAP and shorten the duration of oxygen therapy in neonates with NRDS, which is probably due to the fact that this method can reduce the production of TNF-alpha and SF and inhibit the decrease of IL-10.	Oxygen	43-49	tumor necrosis factor	Homo sapiens	253-262
23060442-4	2012	We show that hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity induced by VEGFA was inhibited by endorepellin independent of oxygen concentration and that only a combination of both PI3K and calcineurin inhibitors completely blocked the suppressive activity evoked by endorepellin on HIF1A and VEGFA promoter activity.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
23060442-4	2012	We show that hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity induced by VEGFA was inhibited by endorepellin independent of oxygen concentration and that only a combination of both PI3K and calcineurin inhibitors completely blocked the suppressive activity evoked by endorepellin on HIF1A and VEGFA promoter activity.	Oxygen	145-151	vascular endothelial growth factor A	Homo sapiens	94-99
23248643-6	2012	Indirect calorimetry revealed that both Ames dwarf and GHR-KO mice utilize more oxygen per gram (g) of body weight than sex- and age-matched normal animals from the same strain.	Oxygen	80-86	growth hormone receptor	Mus musculus	55-58
23131858-1	2012	CdO nanosheet film can be synthesized by electrochemical deposition in an ultra-thin liquid layer by using Cd(NO(3))(2) and HNO(3) as source materials for Cd and oxygen respectively.	Oxygen	162-168	cell adhesion associated, oncogene regulated	Homo sapiens	0-3
23104697-1	2012	The oxygen dependence of mitochondrial oxidative phosphorylation was measured in suspensions of isolated rat liver mitochondria using recently developed methods for measuring oxygen and cytochrome c reduction.	Oxygen	4-10	cytochrome c, somatic	Homo sapiens	186-198
23104697-3	2012	For mitochondrial suspensions with added ATP, metabolic conditions approximating those in intact cells and decreasing oxygen pressure both increased reduction of cytochrome c and decreased respiratory rate.	Oxygen	118-124	cytochrome c, somatic	Homo sapiens	162-174
22544557-11	2012	CONCLUSIONS: These findings point to a role for HIF1alpha in osteosarcoma progression and suggest that the observed differences in HIF1alpha oxygen dependent degradation may play an important pathophysiological role in this disease.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-140
23085741-0	2012	Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.	Oxygen	73-79	cysteinyl leukotriene receptor 1	Homo sapiens	25-57
23247535-10	2012	In addition the administration of continuous oxygen airflow of 2 l min-1 through the suction channel of the flexible bronchoscope was tested as an alternative method to prevent lens fogging.	Oxygen	45-51	CD59 molecule (CD59 blood group)	Homo sapiens	67-72
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
23252979-0	2012	Association between reactive oxygen metabolites and paraoxonase 1 activity during a physical activity increase intervention with older Japanese people.	Oxygen	29-35	paraoxonase 1	Homo sapiens	52-65
22311647-2	2012	Water-forming NADH oxidase (nox-2) can catalyze the conversion of oxygen to water with concomitant NADH oxidation in anaerobic microorganisms.	Oxygen	66-72	SagB/ThcOx family dehydrogenase	Bacillus cereus ATCC 14579	14-26
22855218-7	2012	During strenuous exercising, MPO as well as its educts may be elevated due to increased oxygen intake and excretion of pro-inflammatory mediators inducing host tissue damage via oxidative stress.	Oxygen	88-94	myeloperoxidase	Homo sapiens	29-32
22907804-11	2012	Finally, our in vitro hypoxia-ischemia model, using A172 glioma cells and primary astrocytes, showed that downregulation of Bis blocked the enhanced expression of galectin 3 after oxygen-glucose deprivation.	Oxygen	180-186	lectin, galactose binding, soluble 3	Mus musculus	163-173
23023398-5	2012	HIF-1alpha is the key mediator of the cellular             response to oxygen deprivation and induces the expression of genes involved in             survival and angiogenesis within solid hypoxic tumors.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
23095889-9	2012	We also show that, concurrently, HIF1alpha maintains cellular levels of oxygen, most likely by controlling the expression of pyruvate dehydrogenase kinase 1, an inhibitor of the tricarboxylic acid cycle.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
22890790-5	2012	Seven days and onward after the injections, the PRP/LH/P MPs-treated and PRP-treated groups recovered from ischemia, as reflected by the improved oxygen saturation.	Oxygen	146-152	proline rich protein HaeIII subfamily 1	Mus musculus	48-51
22890790-5	2012	Seven days and onward after the injections, the PRP/LH/P MPs-treated and PRP-treated groups recovered from ischemia, as reflected by the improved oxygen saturation.	Oxygen	146-152	proline rich protein HaeIII subfamily 1	Mus musculus	73-76
22890790-6	2012	In the PRP-treated group, however, the level of recovery of oxygen saturation after ischemia decreased after 14 days.	Oxygen	60-66	proline rich protein HaeIII subfamily 1	Mus musculus	7-10
23042909-2	2012	According to this hypothesis describing the "normobaric oxygen paradox", normoxia following a hyperoxic event is sensed by tissues as an oxygen shortage, upregulating HIF-1 activity.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-172
23042909-2	2012	According to this hypothesis describing the "normobaric oxygen paradox", normoxia following a hyperoxic event is sensed by tissues as an oxygen shortage, upregulating HIF-1 activity.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-172
23042909-3	2012	With the aim of confirming, at cellular and at functional level, that normoxia following a hyperoxic event is "interpreted" as a hypoxic event, we report a combination of experiments addressing the effects of an intermittent increase of oxygen concentration on HIF-1 levels and the activity level of specific oxygen-modulated proteins in cultured human umbilical vein endothelial cells and the effects of hemoglobin levels after intermittent breathing of normobaric high (100%) and low (15%) oxygen in vivo in humans.	Oxygen	237-243	hypoxia inducible factor 1 subunit alpha	Homo sapiens	261-266
23187137-1	2012	Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling.	Oxygen	87-93	vascular endothelial growth factor A	Homo sapiens	188-192
24150080-5	2012	Intra-class correlation coefficient (ICC) scores for power output (W kg(-1)) and oxygen uptake (ml kg(-1) min(-1)) were highly reliable (R1 = 0.96 and 0.96, respectively) and the ICC for RPE was moderately reliable (R1 = 0.83).	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	106-112
22535284-7	2012	Additionally, a higher oxygen tension led to an upregulation of the expression of IL-6, MCP-1, and PPAR-gamma, while ANGPTL4 was downregulated in the hyperoxia group with respect to control.	Oxygen	23-29	interleukin 6	Homo sapiens	82-86
22535284-7	2012	Additionally, a higher oxygen tension led to an upregulation of the expression of IL-6, MCP-1, and PPAR-gamma, while ANGPTL4 was downregulated in the hyperoxia group with respect to control.	Oxygen	23-29	peroxisome proliferator activated receptor gamma	Homo sapiens	99-109
24150080-7	2012	A Pearson"s product-moment correlation demonstrated a strong relationship between power output (W kg(-1)) and oxygen uptake (ml kg(-1) min(-1)) for both trials (r = 0.93 and 0.89, respectively).	Oxygen	110-116	CD59 molecule (CD59 blood group)	Homo sapiens	135-141
23324150-8	2012	CONCLUSION: As an initial factor, low oxygen made HIF-1alpha, ET-1 and iNOS expression raised in the pathogenesis of HPH of the neonatal rats and causedn a imbalance of ET-1 and NO.	Oxygen	38-44	endothelin 1	Rattus norvegicus	62-66
23204802-1	2012	PURPOSE: We investigated whether oxygen-induced retinopathy (OIR) results in changes in the protein expression of neuronal and inducible nitric oxide synthases (nNOS and iNOS, respectively) in rat model of OIR.	Oxygen	33-39	nitric oxide synthase 2	Rattus norvegicus	170-174
23269905-0	2012	Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.	Oxygen	0-6	carbonic anhydrase 3	Homo sapiens	110-113
22982617-2	2012	Hypoxia-inducible factor-1alpha (HIF-1alpha) as a critical oxygen-sensitive transcriptional factor participates in many physiological and pathological processes including PAH.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
22982617-2	2012	Hypoxia-inducible factor-1alpha (HIF-1alpha) as a critical oxygen-sensitive transcriptional factor participates in many physiological and pathological processes including PAH.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
22452597-0	2012	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo (Bubalus bubalis) embryos affect mRNA expression of BCL-2, BCL-XL, MCL-1, BAX and BID.	Oxygen	0-6	apoptosis regulator Bcl-2	Bubalus bubalis	142-147
22452597-6	2012	At the 8- to 16-cell stage, where developmental block occurs in buffalo, the relative mRNA abundance of BCL-2 and MCL-1 was highest under 5% O(2) concentration and that of BAX and BID was highest (p &lt; 0.05) under 20% O(2) concentration.	Oxygen	141-145	apoptosis regulator Bcl-2	Bubalus bubalis	104-109
22452597-6	2012	At the 8- to 16-cell stage, where developmental block occurs in buffalo, the relative mRNA abundance of BCL-2 and MCL-1 was highest under 5% O(2) concentration and that of BAX and BID was highest (p &lt; 0.05) under 20% O(2) concentration.	Oxygen	220-224	apoptosis regulator Bcl-2	Bubalus bubalis	104-109
23324150-8	2012	CONCLUSION: As an initial factor, low oxygen made HIF-1alpha, ET-1 and iNOS expression raised in the pathogenesis of HPH of the neonatal rats and causedn a imbalance of ET-1 and NO.	Oxygen	38-44	nitric oxide synthase 2	Rattus norvegicus	71-75
23324150-8	2012	CONCLUSION: As an initial factor, low oxygen made HIF-1alpha, ET-1 and iNOS expression raised in the pathogenesis of HPH of the neonatal rats and causedn a imbalance of ET-1 and NO.	Oxygen	38-44	endothelin 1	Rattus norvegicus	169-180
23035118-11	2012	Brief hydrogen peroxide treatment or incubation in an enriched oxygen atmosphere led to a marked further reduction of ISCU protein levels, which could be prevented by pretreatment with the antioxidant ascorbate.	Oxygen	63-69	iron-sulfur cluster assembly enzyme	Homo sapiens	118-122
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Oxygen	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23006780-2	2012	Here we report that short exposures to non-physiologic oxygen levels change the balance of the ROS-dependent thioredoxin/peroxiredoxin system in the developing rat brain.	Oxygen	55-61	thioredoxin 1	Rattus norvegicus	109-120
22936271-3	2012	Given that low oxygen levels induce 5-HT production and secretion through a hypoxia inducible factor 1alpha (HIF-1alpha)-dependent pathway, we also hypothesized that increasing O(2) would reduce 5-HT production and secretion.	Oxygen	177-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-107
22936271-3	2012	Given that low oxygen levels induce 5-HT production and secretion through a hypoxia inducible factor 1alpha (HIF-1alpha)-dependent pathway, we also hypothesized that increasing O(2) would reduce 5-HT production and secretion.	Oxygen	177-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
22936271-6	2012	PCR confirmed activation of HIF-downstream targets, GLUT1, IGF2, and VEGF under reduced O(2) levels (0.5%).	Oxygen	88-92	vascular endothelial growth factor A	Homo sapiens	69-73
22936271-8	2012	Increasing O(2) to 100% inhibited HRE-mediated signaling, transcription, reduced 5-HT secretion, and significantly lowered HIF-1alpha levels (~75% of control).	Oxygen	11-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
22936271-10	2012	We concluded that gut EC cells are oxygen responsive, and alterations in O(2) levels differentially activate HIF-1alpha and tryptophan hydroxylase 1, as well as NF-kappaB signaling.	Oxygen	73-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
23006780-5	2012	Oxygen-toxicity significantly induced upregulation of peroxiredoxins 1 and 2, peroxiredoxin sulfonic form, thioredoxin 1, and sulfiredoxin 1 in the brains of infant rats.	Oxygen	0-6	thioredoxin 1	Rattus norvegicus	107-120
22929863-4	2012	In this study, we show that the electrocatalytic oxidation of hydrogen peroxide on a platinum electrode generates reactive oxygen species, presumably surface-bound platinum-oxo species, which are capable of oxygen insertion reactions in analogy to oxo-ferryl radical cations in the active site of Cytochrome P450.	Oxygen	123-129	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	297-312
23007801-9	2012	The mean (SD) corresponding oxygen uptake values for the sedentary, dance, and boxing video games were 6.1 (1.3), 12.8 (3.3), and 17.7 (5.1) mL   min-1   kg-1, respectively.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	146-158
23030649-1	2012	Cytochrome c oxidase encoded by multiple mitochondrial genes (COXI, COXII, and COXIII) and nuclear genes is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c.	Oxygen	212-218	cytochrome c, somatic	Homo sapiens	0-12
23030649-1	2012	Cytochrome c oxidase encoded by multiple mitochondrial genes (COXI, COXII, and COXIII) and nuclear genes is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c.	Oxygen	212-218	cytochrome c, somatic	Homo sapiens	230-242
22915822-1	2012	Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen.	Oxygen	137-143	catalase	Homo sapiens	52-60
22628534-9	2012	Furthermore, the identification of the EGLN1 gene from the HIF pathway suggests a common adaptive mechanism for Eurasian human populations residing at different altitudes with different oxygen pressures.	Oxygen	186-192	egl-9 family hypoxia inducible factor 1	Homo sapiens	39-44
22985120-5	2012	Using this imaging technique, it was possible to demonstrate the spatial pattern of oxygen production and consumption at a c. 20-mum level of resolution, and their visualization in the rhizosphere, stem and leaf, and within the developing seed.	Oxygen	84-90	latexin	Homo sapiens	129-132
22987149-6	2012	Therefore, the effects of hypoxia on the oxygen-sensing mTOR pathway and geroconversion are cell type-specific.	Oxygen	41-47	mechanistic target of rapamycin kinase	Homo sapiens	56-60
22566398-2	2012	The possibility of enhancing oxygen transport through an increase of erythrocytes has led to EPO abuse in sports.	Oxygen	29-35	erythropoietin	Homo sapiens	93-96
22709874-5	2012	RESULTS: First- ly, the percentage of monocytes producing reactive oxygen metabolites was higher in groups with exogenous AFP than the group without AFP exposure.	Oxygen	67-73	alpha fetoprotein	Homo sapiens	122-125
22946054-0	2012	Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	43-47
22956520-6	2012	High O(2)-cultured oocytes also showed higher amounts of SOD1, SOD2, GSR, GPX1, and CAT mRNA.	Oxygen	5-9	superoxide dismutase 1	Canis lupus familiaris	57-61
22956520-6	2012	High O(2)-cultured oocytes also showed higher amounts of SOD1, SOD2, GSR, GPX1, and CAT mRNA.	Oxygen	5-9	catalase	Canis lupus familiaris	84-87
22948140-0	2012	Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.	Oxygen	198-204	lactate dehydrogenase A	Homo sapiens	54-77
23009063-7	2012	The significantly decreased Lewis acidity of the Zr metal center in anions 4a,b (versus neutral analogues) due to the anionic charge and a likely substantial electronic pi donation of the four Zr-O(ArO) oxygens to the Zr metal center may rationalize the moderate polymerization activity.	Oxygen	203-210	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	198-201
23009067-1	2012	The Mn 1s near-edge absorption fine structure (NEXAFS) has been computed by means of transition-state gradient-corrected density functional theory (DFT) on four Mn(4)Ca clusters modeling the successive S(0) to S(3) steps of the oxygen-evolving complex (OEC) in photosystem II (PSII).	Oxygen	228-234	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	4-8
22896706-10	2012	With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells.	Oxygen	483-489	cytoglobin	Homo sapiens	164-168
22896706-10	2012	With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells.	Oxygen	483-489	cytoglobin	Homo sapiens	164-168
22932900-3	2012	Incubation of cancer cells under 1% oxygen for 16 h significantly induced HIF-1alpha expression and activity as assayed by Western blotting and reporter gene analysis.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
23066366-1	2012	STUDY OBJECTIVE: To test the hypothesis that low iron availability, measured as transferrin saturation, is associated with low nocturnal hemoglobin oxygen saturation (SpO(2)) in children with homozygous sickle cell anemia (SCA; hemoglobin SS).	Oxygen	148-154	transferrin	Homo sapiens	80-91
23066366-6	2012	CONCLUSIONS: Contrary to our hypothesis, higher iron availability, assessed by transferrin saturation, is associated with nocturnal chronic and intermittent hemoglobin oxygen desaturation in SCA.	Oxygen	168-174	transferrin	Homo sapiens	79-90
22917661-5	2012	Physical hypoxia (1% oxygen) and CoCl(2) treatment decreased both FGF21 mRNA and secreted protein levels.	Oxygen	21-27	fibroblast growth factor 21	Homo sapiens	66-71
22923613-1	2012	Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin.	Oxygen	11-17	cytochrome p450 oxidoreductase	Homo sapiens	89-120
23202931-3	2012	Earlier we demonstrated that oxygen contributes to the pathogenesis of neonatal brain damage, which can be ameliorated by intervention with recombinant human erythropoietin (rhEpo).	Oxygen	29-35	erythropoietin	Homo sapiens	158-172
22910906-1	2012	The mRNA of hif-1alpha is considered as being constitutively and ubiquitously expressed, regardless of the level of oxygen tension.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
22885714-0	2012	Structural and oxygen binding properties of dimeric horse myoglobin.	Oxygen	15-21	myoglobin	Equus caballus	58-67
22885714-1	2012	Myoglobin (Mb) stores dioxygen in muscles, and is a fundamental model protein widely used in molecular design.	Oxygen	22-30	myoglobin	Equus caballus	0-9
22910906-2	2012	However many recent reports have showed that hif-1alpha mRNA could be regulated by natural antisense transcripts, potential microRNAs, and low O(2).	Oxygen	143-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
23045974-0	2012	Thymosin beta4 stabilizes hypoxia-inducible factor-1alpha protein in an oxygen-independent manner.	Oxygen	72-78	thymosin beta 4 X-linked	Homo sapiens	0-14
22966761-2	2012	The resultant POMC with a small amount of P doping is demonstrated as a metal-free electrode with excellent electrocatalytic activity for oxygen reduction reaction (ORR), coupled with much enhanced stability and alcohol tolerance compared to those of platinum via four-electron pathway in alkaline medium.	Oxygen	138-144	proopiomelanocortin	Homo sapiens	14-18
22915309-5	2012	The MSIT-related blood oxygen level-dependent (BOLD) response was increased with increasing copies of the TPH2 yin haplotype for the dorsal anterior cingulate cortex (dACC), right inferior frontal cortex (IFC), and anterior striatum.	Oxygen	23-29	Acetyl-CoA carboxylase	Drosophila melanogaster	167-171
22791340-9	2012	The dual regulation by NO of oxygen supply and demand is predicted to significantly attenuate the hypoxic effects of angiotensin II.	Oxygen	29-35	angiotensinogen	Rattus norvegicus	117-131
23045974-7	2012	These data suggest that Tbeta4 indirectly induces VEGF expression by increasing the protein stability of HIF-1alpha in an oxygen-independent manner.	Oxygen	122-128	thymosin beta 4 X-linked	Homo sapiens	24-30
23045974-7	2012	These data suggest that Tbeta4 indirectly induces VEGF expression by increasing the protein stability of HIF-1alpha in an oxygen-independent manner.	Oxygen	122-128	vascular endothelial growth factor A	Homo sapiens	50-54
22703030-3	2012	The O2 uptake reported by the Moxus system was 83 +- 78 mL min-1 higher (mean +- SD;  3%, +62 micromol s-1, P &lt; 0.001) than that reported by the Douglas-bag method; the bias varied by  2% between the subjects.	Oxygen	4-6	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
23045974-7	2012	These data suggest that Tbeta4 indirectly induces VEGF expression by increasing the protein stability of HIF-1alpha in an oxygen-independent manner.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
22932316-8	2012	The close proximity of the 5"-carbonyl oxygen atom in 2-7 to the sulfur atom of Met274 in HDAC8 or the corresponding isobutyl group of Leu274 in HDAC1 may attenuate potency through repulsive steric and dipole-dipole forces.	Oxygen	39-45	histone deacetylase 1	Homo sapiens	145-150
22926288-4	2012	It has been previously shown that PRP and NP inhibit overproduction of reactive oxygen species, nitric oxide and proinflammatory cytokines induced by lipopolysaccharide or PMA.	Oxygen	80-86	prion protein	Homo sapiens	34-37
22846601-8	2012	SOD must favor reduction of oxygen by the INH radical to give superoxide and ultimately hydrogen peroxide.	Oxygen	28-34	superoxide dismutase 1	Homo sapiens	0-3
22742515-8	2012	Insulin treatment increased oxygen consumption but reduced mitochondrial membrane potential and ROS production.	Oxygen	28-34	insulin	Homo sapiens	0-7
22875277-1	2012	2-Oxoglutarate or alpha-ketoglutarate (alphaKG) is a substrate of HIF prolyl hydroxylases 1-3 that decrease cellular levels of the hypoxia-inducible factor 1alpha (HIF-1alpha) in the presence of oxygen.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-162
23122309-8	2012	NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet.	Oxygen	110-116	nitric oxide synthase 3	Homo sapiens	0-4
22872171-6	2012	Genetic and pharmacological interventions to inhibit the major source of reactive oxygen species, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, are neuroprotective in experimental cerebral ischemia.	Oxygen	82-88	dual oxidase 2	Homo sapiens	98-157
22922758-4	2012	Accordingly, expression of mutant LC3B with impaired ceramide binding, as predicted by molecular modeling, prevented CerS1-mediated mitochondrial targeting, recovering oxygen consumption.	Oxygen	168-174	ceramide synthase 1	Homo sapiens	117-122
22814443-0	2012	Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen.	Oxygen	72-78	cytochrome c, somatic	Homo sapiens	0-12
26201518-2	2012	Inadequate oxygen uptake by the hepatocytes resulting in centrilobular necrosis associated with abnormally raised levels of the serum transaminases (ALT, AST) in patients with clinical history of cardiac, respiratory, or circulatory failures is the key feature of this condition.	Oxygen	11-17	solute carrier family 17 member 5	Homo sapiens	154-157
22633996-7	2012	The second series of experiments revealed that c-fos protein and mRNA expression in the hippocampus neurons (CA1) increased in naked mole rats that were repeatedly exposed to 3% O2 for 60 min per day for 5 days when compared to normoxia.	Oxygen	178-180	carbonic anhydrase 1	Heterocephalus glaber	109-112
22875277-1	2012	2-Oxoglutarate or alpha-ketoglutarate (alphaKG) is a substrate of HIF prolyl hydroxylases 1-3 that decrease cellular levels of the hypoxia-inducible factor 1alpha (HIF-1alpha) in the presence of oxygen.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-174
23311134-7	2012	The expression of cyp2e1 in transgenic tobacco with cyp2e1 decreased obviously treated by ethyl alcohol and reduced slightly by benzene and toluene, while it enhanced by acetone, formaldehyde and oxygen deficit in different levels.	Oxygen	196-202	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-24
22884420-0	2012	Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.	Oxygen	0-6	ribosomal protein SA	Homo sapiens	34-57
22884420-2	2012	In this study, we found that 67LR protein levels are reduced by exposure to low O(2) levels (5%), without affecting the expression of HIF-1alpha.	Oxygen	80-84	ribosomal protein SA	Homo sapiens	29-33
22884420-5	2012	In summary, 67LR expression is highly sensitive to O(2) partial pressure, and the activity of EGCG can be regulated in cancer cells by O(2) partial pressure.	Oxygen	51-55	ribosomal protein SA	Homo sapiens	12-16
22884420-5	2012	In summary, 67LR expression is highly sensitive to O(2) partial pressure, and the activity of EGCG can be regulated in cancer cells by O(2) partial pressure.	Oxygen	135-139	ribosomal protein SA	Homo sapiens	12-16
22365890-1	2012	The enzyme catalase catalyzes the breakdown of hydrogen peroxide into oxygen and water.	Oxygen	70-76	catalase	Homo sapiens	11-19
22990116-5	2012	Mitochondrial ROS production is thought to play a role in hypoxia signaling by stabilizing the oxygen-sensitive transcription factor hypoxia-inducible factor-1alpha.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-164
22843785-1	2012	RATIONALE: Kv1.5 (KCNA5) is expressed in the heart, where it underlies the I(Kur) current that controls atrial repolarization, and in the pulmonary vasculature, where it regulates vessel contractility in response to changes in oxygen tension.	Oxygen	227-233	potassium voltage-gated channel subfamily A member 5	Homo sapiens	11-16
22760073-1	2012	Hypoxia-inducible factor-1 (HIF-1) consists of two subunits, the HIF-1beta, which is constitutively expressed, and HIF-1alpha, which is oxygen-responsive.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
22760073-1	2012	Hypoxia-inducible factor-1 (HIF-1) consists of two subunits, the HIF-1beta, which is constitutively expressed, and HIF-1alpha, which is oxygen-responsive.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
22760073-1	2012	Hypoxia-inducible factor-1 (HIF-1) consists of two subunits, the HIF-1beta, which is constitutively expressed, and HIF-1alpha, which is oxygen-responsive.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
22841759-0	2012	Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?	Oxygen	24-30	tumor protein p53	Homo sapiens	56-59
22843785-1	2012	RATIONALE: Kv1.5 (KCNA5) is expressed in the heart, where it underlies the I(Kur) current that controls atrial repolarization, and in the pulmonary vasculature, where it regulates vessel contractility in response to changes in oxygen tension.	Oxygen	227-233	potassium voltage-gated channel subfamily A member 5	Homo sapiens	18-23
22659352-12	2012	We demonstrate that oxygen transport limitations result in significant heterogeneity in HIF-1 alpha signalling and cell-cycle status, and when these are combined with drug transport limitations, the efficacy of the therapy is significantly impaired.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-99
22885059-6	2012	We compared the pattern of blood oxygen level-dependent activity evoked by each object before and after this exposure, and found that perirhinal cortex, parahippocampal cortex, subiculum, CA1, and CA2/CA3/dentate gyrus (CA2/3/DG) encoded regularities by increasing the representational similarity of their constituent objects.	Oxygen	33-39	carbonic anhydrase 3	Homo sapiens	201-204
22871579-3	2012	The docking results suggested that these alkenyl derivatives containing ester moiety interact well with the PDE4B protein in silico where the ester carbonyl oxygen played a key role.	Oxygen	157-163	phosphodiesterase 4B	Homo sapiens	108-113
22900546-2	2012	The migration reaction occurred in a conformation in which the carbonyl oxygen and the TMS group were antiperiplanar to predominantly afford trans-seven-membered ketones.	Oxygen	72-78	PYD and CARD domain containing	Homo sapiens	87-90
22639088-5	2012	The effects of catalase, glutathione and ascorbate on the reaction were all consistent with a direct oxygen insertion mechanism, as opposed to a radical mechanism.	Oxygen	101-107	catalase	Homo sapiens	15-23
21912865-1	2012	Sediment oxygen demand (SOD) has become an integral part of modeling dissolved oxygen (DO) within surface water bodies.	Oxygen	9-15	superoxide dismutase 1	Homo sapiens	24-27
22709448-2	2012	In this study, we investigated whether Src and Fyn kinases, two major members of SrcPTKs in the brain, have distinct roles in the oxygen and glucose deprivation (OGD) and amyloid-beta peptide (Abeta)-induced neuronal apoptosis.	Oxygen	130-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	39-42
22389124-3	2012	Insulin-producing pancreatic beta cells are known to be highly susceptible to oxygen deficiency.	Oxygen	78-84	insulin	Homo sapiens	0-7
22711313-1	2012	Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine and oxygen by the enzyme nitric oxide synthase (NOS).	Oxygen	98-104	nitric oxide synthase 2	Homo sapiens	119-140
21912865-1	2012	Sediment oxygen demand (SOD) has become an integral part of modeling dissolved oxygen (DO) within surface water bodies.	Oxygen	79-85	superoxide dismutase 1	Homo sapiens	24-27
22683849-1	2012	Application of recombinant human erythropoietin (rhEpo) improves exercise capacity by stimulating red blood cell production that, in turn, enhances oxygen delivery and utilization.	Oxygen	148-154	erythropoietin	Homo sapiens	33-47
22899010-5	2012	Depletion of IMP2 in gliomaspheres decreases their oxygen consumption rate and both complex I and complex IV activity that results in impaired clonogenicity in vitro and tumorigenicity in vivo.	Oxygen	51-57	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	13-17
22736084-0	2012	TGF-beta1 and IGF-1 influence the re-differentiation capacity of human             chondrocytes in 3D pellet cultures in relation to different oxygen concentrations.	Oxygen	143-149	transforming growth factor beta 1	Homo sapiens	0-9
22994514-5	2012	Since the master regulator of the hypoxic response, hypoxia inducible factor 1 (HIF-1), is a key determinant for adaptation of cells and tissues to oxygen deprivation, it is likely that this transcription factor also plays a key role in barrier permeability.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-78
22994514-5	2012	Since the master regulator of the hypoxic response, hypoxia inducible factor 1 (HIF-1), is a key determinant for adaptation of cells and tissues to oxygen deprivation, it is likely that this transcription factor also plays a key role in barrier permeability.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
22994514-6	2012	The possible future use of HIF-1 stabilizers for treatment of diseases characterized by oxygen deprivation to increase neuronal/cell survival means this question is now very pertinent.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-32
22994516-5	2012	Here, reduced oxygen tension activates a hypoxic response that culminates in an increased expression of vascular endothelial growth factor.	Oxygen	14-20	vascular endothelial growth factor A	Homo sapiens	104-138
22736084-0	2012	TGF-beta1 and IGF-1 influence the re-differentiation capacity of human             chondrocytes in 3D pellet cultures in relation to different oxygen concentrations.	Oxygen	143-149	insulin like growth factor 1	Homo sapiens	14-19
22929836-9	2012	Under oxidative stress conditions, eNOS for example can switch from producing NO to O2 - in a process called uncoupling, which is believed to be caused by oxidation of heme or the co-factor, tetrahydrobiopterin (BH4).	Oxygen	84-86	nitric oxide synthase 3	Homo sapiens	35-39
22805345-6	2012	Oxygen consumption and high-resolution respirometry analyses showed that mTAL cells and the mitochondria in the outer medulla of SS rats fed high-salt diet exhibited lower rates of oxygen utilization compared with those from SS.13(BN) rats.	Oxygen	0-6	talipes	Mus musculus	73-77
22805345-6	2012	Oxygen consumption and high-resolution respirometry analyses showed that mTAL cells and the mitochondria in the outer medulla of SS rats fed high-salt diet exhibited lower rates of oxygen utilization compared with those from SS.13(BN) rats.	Oxygen	181-187	talipes	Mus musculus	73-77
22747465-1	2012	Prolyl hydroxylase domain 2 (PHD2) is deemed a primary oxygen sensor in humans, yet many details of its underlying mechanism are still not fully understood.	Oxygen	55-61	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-27
22747465-1	2012	Prolyl hydroxylase domain 2 (PHD2) is deemed a primary oxygen sensor in humans, yet many details of its underlying mechanism are still not fully understood.	Oxygen	55-61	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-33
22320379-5	2012	RESULTS: The findings show that interleukin concentrations (IL-6, IL-8, TNF-alpha) were significantly decreased between 0 and 72 hours (p &lt; 0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group.	Oxygen	184-190	interleukin 6	Homo sapiens	60-64
22320379-5	2012	RESULTS: The findings show that interleukin concentrations (IL-6, IL-8, TNF-alpha) were significantly decreased between 0 and 72 hours (p &lt; 0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group.	Oxygen	184-190	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
22320379-5	2012	RESULTS: The findings show that interleukin concentrations (IL-6, IL-8, TNF-alpha) were significantly decreased between 0 and 72 hours (p &lt; 0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group.	Oxygen	184-190	tumor necrosis factor	Homo sapiens	72-81
22833559-7	2012	In addition, the model predicts that increased Ofd1 production at low oxygen plays an important role in the hypoxic response, and the model indicates that the Ofd1 binding partner Nro1 tunes the response to oxygen.	Oxygen	70-76	Ett1p	Saccharomyces cerevisiae S288C	180-184
22833559-7	2012	In addition, the model predicts that increased Ofd1 production at low oxygen plays an important role in the hypoxic response, and the model indicates that the Ofd1 binding partner Nro1 tunes the response to oxygen.	Oxygen	207-213	Ett1p	Saccharomyces cerevisiae S288C	180-184
22669298-7	2012	After correcting for age and adiposity in multiple-regression models, Log frequency of desaturation (defined as &gt;=3% drop in oxygen saturation from baseline) negatively correlated with insulin sensitivity.	Oxygen	128-134	insulin	Homo sapiens	188-195
23363896-11	2012	Serum adiponectin levels are related to the severity of OSAS and arterial oxygen saturation.	Oxygen	74-80	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
22907205-6	2012	Fibroblast growth factor-1 (FGF-1) is a naturally occurring growth factor that is able to stimulate blood vessel formation and improve oxygen levels in ischemic tissues.	Oxygen	135-141	fibroblast growth factor 1	Homo sapiens	0-26
22659133-3	2012	Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of genes essential for adaptation to low oxygen conditions.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
22659133-3	2012	Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of genes essential for adaptation to low oxygen conditions.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
22120717-4	2012	Here we report that short hairpin RNA-mediated gene suppression of wild-type p53 or ectopic expression of mutant temperature-sensitive dominant-negative p53(V135A) increased glucose consumption and lactate production, decreased oxygen consumption and enhanced hypoxia-induced cell death in p53 wild-type human glioblastoma cells.	Oxygen	228-234	tumor protein p53	Homo sapiens	77-80
22120717-4	2012	Here we report that short hairpin RNA-mediated gene suppression of wild-type p53 or ectopic expression of mutant temperature-sensitive dominant-negative p53(V135A) increased glucose consumption and lactate production, decreased oxygen consumption and enhanced hypoxia-induced cell death in p53 wild-type human glioblastoma cells.	Oxygen	228-234	tumor protein p53	Homo sapiens	153-156
22120717-4	2012	Here we report that short hairpin RNA-mediated gene suppression of wild-type p53 or ectopic expression of mutant temperature-sensitive dominant-negative p53(V135A) increased glucose consumption and lactate production, decreased oxygen consumption and enhanced hypoxia-induced cell death in p53 wild-type human glioblastoma cells.	Oxygen	228-234	tumor protein p53	Homo sapiens	153-156
22789427-2	2012	Stabilization of a key regulator termed the hypoxia inducible factor (HIF)-1alpha under oxygen deficient environment around tumor is known to elicit expression of VEGF through binding to p300.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-81
22789427-2	2012	Stabilization of a key regulator termed the hypoxia inducible factor (HIF)-1alpha under oxygen deficient environment around tumor is known to elicit expression of VEGF through binding to p300.	Oxygen	88-94	vascular endothelial growth factor A	Homo sapiens	163-167
22897855-2	2012	Prolyl hydroxylase domain protein 2 (PHD2) is an oxygen/redox-sensitive enzyme that induces cellular adaptations to stress conditions.	Oxygen	49-55	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-35
22897855-2	2012	Prolyl hydroxylase domain protein 2 (PHD2) is an oxygen/redox-sensitive enzyme that induces cellular adaptations to stress conditions.	Oxygen	49-55	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
22907205-6	2012	Fibroblast growth factor-1 (FGF-1) is a naturally occurring growth factor that is able to stimulate blood vessel formation and improve oxygen levels in ischemic tissues.	Oxygen	135-141	fibroblast growth factor 1	Homo sapiens	28-33
22747342-0	2012	Vibrational relaxation of O2(X3Sigma(-)g, v = 6-8) by collisions with O2(X3Sigma(-)g, v = 0): solution of the problems in the integrated profiles method.	Oxygen	26-28	CD101 molecule	Homo sapiens	29-49
22870988-11	2012	RESULTS: We demonstrate, using primary human monocytes and hMDM, that the localization of transcription factor HIF-1alpha during the differentiation process is shifted from the cytosol (in monocytes) into the nucleus (in macrophages), apparently as an adaptation to a low oxygen environment.	Oxygen	272-278	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
22703473-2	2012	Irradiation of the arsenite/goethite under conditions where dissolved oxygen was present in solution led to the presence of arsenate (As(V)) product adsorbed on goethite and in solution.	Oxygen	70-76	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	134-139
22747342-0	2012	Vibrational relaxation of O2(X3Sigma(-)g, v = 6-8) by collisions with O2(X3Sigma(-)g, v = 0): solution of the problems in the integrated profiles method.	Oxygen	70-72	CD101 molecule	Homo sapiens	29-49
22747342-2	2012	The problem that plots for linear regression in the IPM analysis cannot be made, however, has been found in the study of self relaxation of O2(X3Sigma(-)g, v = 6-8).	Oxygen	140-142	CD101 molecule	Homo sapiens	143-163
22275240-7	2012	Notch-1 intracellular domain (NICD) expression was significantly higher in synovial tissue from patients with tissue PO2 of &lt;20 mm Hg (&lt;3% O2) than in those with tissue PO2 of &gt;20 mm Hg (&gt;3% O2).	Oxygen	118-120	notch receptor 1	Homo sapiens	0-7
21713375-3	2012	We have recently shown that angiotensin II enhances dopaminergic degeneration by increasing levels of reactive oxygen species and neuroinflammation, and that there is an aging-related increase in angiotensin II activity in the substantia nigra in rats, which may constitute a major factor in the increased risk of Parkinson"s disease with aging.	Oxygen	111-117	angiotensinogen	Rattus norvegicus	28-42
22718803-1	2012	Maternally derived inflammatory mediators, such as IL-6 and IL-8, contribute to preterm delivery, low birth weight, and respiratory insufficiency, which are routinely treated with oxygen.	Oxygen	180-186	interleukin 6	Mus musculus	51-55
22653840-9	2012	CONCLUSIONS: With our modern anesthesia machines, reducing the fresh gas flow of oxygen to 0.3-0.5 L min(-1) and using third-generation inhaled anesthetics provide a reassuringly safe anesthetic technique.	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	101-107
22521680-5	2012	In protein adsorption experiments, human serum albumin (HSA) and fibrinogen (Fg) were adsorbed on untreated and oxygen plasma treated PET and PP surfaces.	Oxygen	112-118	fibrinogen beta chain	Homo sapiens	41-75
22269009-0	2012	Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans.	Oxygen	11-17	insulin	Homo sapiens	46-53
22269009-3	2012	The aim of this study was to determine whether peripheral insulin sensitivity by hyperinsulinaemic euglycaemic clamp is increased in patients presenting for hyperbaric oxygen therapy.	Oxygen	168-174	insulin	Homo sapiens	58-65
22269009-9	2012	CONCLUSION: Insulin sensitivity increased within 3 days of hyperbaric oxygen treatment and this was maintained for 30 sessions.	Oxygen	70-76	insulin	Homo sapiens	12-19
22269009-11	2012	The mechanisms underlying the insulin-sensitizing effect of hyperbaric oxygen require further elucidation.	Oxygen	71-77	insulin	Homo sapiens	30-37
22729570-8	2012	Heart rate (HR) was found to be significantly associated with the eNOS3 SNP (rs1799983) and arterial oxygen saturation of hemoglobin (SaO2) was found to be significantly associated with the VEGFA SNPs (rs13207351, rs1570360) in Han patients with AMS.	Oxygen	101-107	vascular endothelial growth factor A	Homo sapiens	190-195
22212640-0	2012	Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption.	Oxygen	86-92	gap junction protein, alpha 1	Mus musculus	14-25
22212640-3	2012	Therefore, we analysed the importance of mitochondrial Cx43 for oxygen consumption.	Oxygen	64-70	gap junction protein, alpha 1	Mus musculus	55-59
22689692-1	2012	BACKGROUND AND OBJECTIVE: The nuclear receptor peroxisome proliferator activated receptor gamma (PPARgamma) contributes to placental development and thus to the maternofetal transfer of oxygen and nutrients that allow for prenatal growth.	Oxygen	186-192	peroxisome proliferator activated receptor gamma	Homo sapiens	97-106
22537771-6	2012	L-4F inhibited the expression and activity of HIF-1alpha induced by low oxygen concentration, cobalt chloride (CoCl(2), a hypoxia-mimic compound), lysophosphatidic acid, and insulin in two human ovarian cancer cell lines, OV2008 and CAOV-3.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
23027351-1	2012	This study aimed at exploring the expression of Surfactant protein-C (SP-C) and Ki67 in autopsy lung tissues of premature infants dying from respiratory distress syndrome (RDS) who were exposed to mechanical ventilation and elevated oxygen concentrations.	Oxygen	233-239	surfactant protein C	Homo sapiens	48-68
23027351-9	2012	Thus our results suggest SP-C and Ki67 may have participated in the pulmonary pathological process in ventilated/oxygen treated preterm infants with RDS, and exogenous surfactant had no effect on the expression of SP-C and Ki67 in the lungs of ventilated/oxygen treated preterm infants with RDS.	Oxygen	113-119	surfactant protein C	Homo sapiens	25-29
22713662-8	2012	Consistently, ATR inhibition sensitised tumour cell lines to a range of oxygen tensions.	Oxygen	72-78	ATR serine/threonine kinase	Homo sapiens	14-17
23700522-0	2012	Differentiation of human adipocytes at physiological oxygen levels results in increased adiponectin secretion and isoproterenol-stimulated lipolysis.	Oxygen	53-59	adiponectin, C1Q and collagen domain containing	Homo sapiens	88-99
23700522-12	2012	This study demonstrates that oxygen levels during adipogenesis are important factors altering adipocyte functionality such as adipokine release, in particular adiponectin secretion, as well as the hormone-induced lipolytic pathway.	Oxygen	29-35	adiponectin, C1Q and collagen domain containing	Homo sapiens	159-170
22566116-11	2012	Ventilator, oxygen supplementation, and hospital days correlated with TA IFN-gamma levels (all p &lt;= 0.01).	Oxygen	12-18	interferon gamma	Homo sapiens	73-82
22516622-6	2012	FINDINGS: Ensemble-averaged oxygen uptakes across pedal cadences were higher during stepping (448 (75) ml min(-1)) compared to cycling (422 (54) ml min(-1)).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	106-112
22516622-6	2012	FINDINGS: Ensemble-averaged oxygen uptakes across pedal cadences were higher during stepping (448 (75) ml min(-1)) compared to cycling (422 (54) ml min(-1)).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	148-154
22717724-7	2012	Supplemental oxygen should only be used if, despite effective ventilation, the heart rate does not increase above 100  beats  min(-1), or if oxygenation as indicated by pulse oximetry, remains unacceptably low.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	126-132
22208333-10	2012	This condition may lead to long-term accumulation of reactive oxygen metabolites resulting in a pro-oxidation milieu, which in turn can lead to increased peroxide levels and decreased antioxidant PON1 activity.	Oxygen	62-68	paraoxonase 1	Homo sapiens	196-200
22449275-10	2012	CONCLUSIONS: IL-6-634 polymorphism is associated with duration of oxygen therapy in VLBW infants.	Oxygen	66-72	interleukin 6	Homo sapiens	13-17
22750003-1	2012	Cytoglobin, a new member of the mammalian heme-globin family has been shown to bind oxygen and to have cell protective properties in vitro.	Oxygen	84-90	cytoglobin	Homo sapiens	0-10
22750246-2	2012	Hypoxia has pronounced effects on almost every aspect of cell physiology, and the nuclear transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) regulates adaptive responses to low concentrations of oxygen in mammalian cells.	Oxygen	210-216	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
22750246-2	2012	Hypoxia has pronounced effects on almost every aspect of cell physiology, and the nuclear transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) regulates adaptive responses to low concentrations of oxygen in mammalian cells.	Oxygen	210-216	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
22750246-6	2012	To investigate the effect of low oxygen concentration on ALOX15 we incubated human vascular muscle cells in hypoxia and showed that expression of ALOX15 increased 22-fold compared with cells incubated in normoxic conditions.	Oxygen	33-39	arachidonate 15-lipoxygenase	Homo sapiens	57-63
22750246-6	2012	To investigate the effect of low oxygen concentration on ALOX15 we incubated human vascular muscle cells in hypoxia and showed that expression of ALOX15 increased 22-fold compared with cells incubated in normoxic conditions.	Oxygen	33-39	arachidonate 15-lipoxygenase	Homo sapiens	146-152
22815500-7	2012	Our data indicate that tPA activates a cell signaling pathway that allows neurons to sense and adapt to oxygen and glucose deprivation.	Oxygen	104-110	plasminogen activator, tissue type	Homo sapiens	23-26
22467849-5	2012	Hypoxic upregulation of lipin 1 expression involves predominantly HIF-1, which binds to a single distal hypoxia-responsive element in the lipin 1 gene promoter and causes its activation under low oxygen conditions.	Oxygen	196-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-71
22234530-8	2012	Moreover, oxyphilic interactions of the cations with the oxygen atoms of the peptide backbone also contribute as further van-der-Waals interactions of the Cs(+) substituted angiotensin II.	Oxygen	57-63	angiotensinogen	Homo sapiens	173-187
22676472-6	2012	The Raman spectroscopy studies indicated also that the ammonium cations are coordinated by the ether-type oxygen atoms of the PPO chains backbone, whereas the amine groups of the urea linkage participate in the (PtCl3EtOH)(-) anion coordination.	Oxygen	106-112	protoporphyrinogen oxidase	Homo sapiens	126-129
22676472-7	2012	In situ Raman monitoring of Pt species decomplexation induced by immersion of hybrid matrix in water highlighted the specific participation of Pt ligands in interaction with the urea group and of NH4(+) cations coordinated by ether-type oxygen atoms in the formation of supramolecular interactions between the PPO chains.	Oxygen	237-243	protoporphyrinogen oxidase	Homo sapiens	310-313
22648410-0	2012	Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.	Oxygen	110-116	F-box and leucine rich repeat protein 5	Homo sapiens	72-77
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Oxygen	105-111	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Oxygen	105-111	iron responsive element binding protein 2	Homo sapiens	56-60
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Oxygen	179-185	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Oxygen	179-185	iron responsive element binding protein 2	Homo sapiens	56-60
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Oxygen	179-185	F-box and leucine rich repeat protein 5	Homo sapiens	140-145
22648410-4	2012	Here, we investigated the iron- and oxygen-dependent conformational changes within FBXL5-Hr that underlie its role as a cellular sensor.	Oxygen	36-42	F-box and leucine rich repeat protein 5	Homo sapiens	83-88
22831473-3	2012	Erythropoiesis, which takes place in bone marrow, is under the control of EPO, a hormone secreted primarily by the kidneys when the arterial oxygen tension decreases.	Oxygen	141-147	erythropoietin	Homo sapiens	74-77
22275240-7	2012	Notch-1 intracellular domain (NICD) expression was significantly higher in synovial tissue from patients with tissue PO2 of &lt;20 mm Hg (&lt;3% O2) than in those with tissue PO2 of &gt;20 mm Hg (&gt;3% O2).	Oxygen	145-147	notch receptor 1	Homo sapiens	0-7
22593272-5	2012	Exposure to a low oxygen concentration (1%) increased gastrin mRNA concentrations in wild-type AGS cells (AGS) and in AGS cells overexpressing the gastrin receptor (AGS-cholecystokinin receptor 2) by 2.1 +- 0.4- and 4.1 +- 0.3-fold (P &lt; 0.05), respectively.	Oxygen	18-24	cholecystokinin B receptor	Homo sapiens	147-163
22424214-0	2012	Systematic investigation of oxygen and growth factors in clinically valid ex vivo expansion of cord blood CD34(+) hematopoietic progenitor cells.	Oxygen	28-34	CD34 molecule	Homo sapiens	106-110
22424214-5	2012	METHODS: This is the first study to characterize systematically the effect of growth factor combinations across multiple oxygen levels on the ex vivo expansion of cord blood CD34(+) hematopoietic cells utilizing clinically approvable reagents and methodologies throughout.	Oxygen	121-127	CD34 molecule	Homo sapiens	174-178
21979130-2	2012	Hypoxia inducible factor-1alpha (HIF-1alpha) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
22426121-7	2012	Third, the effect of hypoxia was mediated by HIF1alpha, since the addition of an HIF1alpha inhibitor at 3% O(2) increased the number of NGN3-expressing progenitors as compared to nontreated controls (9.2-fold, P&lt;0.001).	Oxygen	107-111	neurogenin 3	Mus musculus	136-140
22588007-6	2012	Determination of the reduction potentials of ETF showed that thermodynamic properties of the FAD cofactor are changed upon formation of a complex between ETF and MCAD, supporting the notion that protein:protein interactions modulate the reactivity of the protein with dioxygen.	Oxygen	268-276	acyl-CoA dehydrogenase medium chain	Homo sapiens	162-166
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	interleukin 6	Mus musculus	254-258
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	mast cell protease 1	Mus musculus	263-268
22988612-2	2012	In the absence of any textile preparation chemical, NP-10 degradation was complete in 15 min (rate coefficient: 0.22 min(-1)) accompanied by 78% chemical oxygen demand (COD) (rate coefficient: 0.026 min(-1)) and 57% total organic carbon (TOC) (rate coefficient: 0.014 min(-1)) removals achieved after 60 min photochemical treatment.	Oxygen	154-160	nuclear receptor subfamily 4 group A member 1	Homo sapiens	52-57
21979130-2	2012	Hypoxia inducible factor-1alpha (HIF-1alpha) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
22552373-5	2012	Angiogenesis is regulated by a list of factors, also known             as growth factors, such as the vascular endothelial growth factor (VEGF), the             placental growth factor (PlGF) and the basic fibroblastic growth factor (bFGF),             as well as the partial pressure of oxygen in the fetoplacental vessels.	Oxygen	288-294	vascular endothelial growth factor A	Homo sapiens	138-142
22460831-4	2012	Exposure of renal epithelial HK-2 cells to oxygen and glucose reintroduction after depletion resulted in an increase in nuclear translocation of Nrf2 protein in a manner dependent upon glucose.	Oxygen	43-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
22661086-4	2012	Exposure of mice deficient in IRAK-M (IRAK-M(-/-)) to 95% oxygen resulted in reduced mortality compared with wild-type mice and occurred in association with decreased alveolar permeability and cell death.	Oxygen	58-64	interleukin-1 receptor-associated kinase 3	Mus musculus	30-36
22661086-4	2012	Exposure of mice deficient in IRAK-M (IRAK-M(-/-)) to 95% oxygen resulted in reduced mortality compared with wild-type mice and occurred in association with decreased alveolar permeability and cell death.	Oxygen	58-64	interleukin-1 receptor-associated kinase 3	Mus musculus	38-44
22148982-1	2012	PURPOSE: To explore the effect of resveratrol on B-cell leukemia/lymphoma-2 (Bcl-2) and vascular endothelial growth factor (VEGF) expression in rats with oxygen-induced retinopathy of prematurity (ROP).	Oxygen	154-160	BCL2, apoptosis regulator	Rattus norvegicus	77-82
22148982-11	2012	CONCLUSION: Resveratrol can significantly inhibit expression of Bcl-2 and VEGF in the retina of neonatal rats with oxygen-induced ROP.	Oxygen	115-121	BCL2, apoptosis regulator	Rattus norvegicus	64-69
22495066-8	2012	In an oxygen-induced retinopathy model, one intravitreous injection of PEGylated-PEDF after mouse pups were moved into room air resulted in a significant difference in the inhibition of retinal neovascularization, which decreased the nonperfusion area, compared with the PEDF-treated group.	Oxygen	6-12	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	81-85
22754038-8	2012	Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO2) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not.	Oxygen	0-6	interleukin 6	Homo sapiens	108-112
22588047-1	2012	Acute dietary nitrate (NO3-) supplementation has been reported to lower resting blood pressure, reduce the oxygen (O2) cost of sub-maximal exercise, and improve exercise tolerance.	Oxygen	107-113	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
22588047-1	2012	Acute dietary nitrate (NO3-) supplementation has been reported to lower resting blood pressure, reduce the oxygen (O2) cost of sub-maximal exercise, and improve exercise tolerance.	Oxygen	115-117	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
21193295-8	2012	The change in hsCRP was associated with apnea-hypopnea index, and improving night-time oxygen saturation was related to tumor necrosis factor alpha.	Oxygen	87-93	tumor necrosis factor	Homo sapiens	120-147
22960547-2	2012	mTOR activity responds to many signals, including cellular stress, oxygen, nutrient availability, energy status and growth factors.	Oxygen	67-73	mechanistic target of rapamycin kinase	Homo sapiens	0-4
22811423-2	2012	The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the HIF family of transcriptional activators has provided insight into the molecular underpinnings of oxygen homeostasis.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-43
22811423-2	2012	The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the HIF family of transcriptional activators has provided insight into the molecular underpinnings of oxygen homeostasis.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-50
22754038-8	2012	Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO2) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not.	Oxygen	0-6	C-reactive protein	Homo sapiens	117-120
22450332-4	2012	In this study, a plasmid expressing vascular endothelial growth factor (VEGF) was constructed with an oxygen dependent degradation (ODD) domain and a secretion signal peptide (SP) in order to stabilize the VEGF protein and facilitate the secretion of VEGF protein, specifically under hypoxic conditions.	Oxygen	102-108	vascular endothelial growth factor A	Homo sapiens	36-70
22450332-4	2012	In this study, a plasmid expressing vascular endothelial growth factor (VEGF) was constructed with an oxygen dependent degradation (ODD) domain and a secretion signal peptide (SP) in order to stabilize the VEGF protein and facilitate the secretion of VEGF protein, specifically under hypoxic conditions.	Oxygen	102-108	vascular endothelial growth factor A	Homo sapiens	72-76
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	340-344	cytochrome p450 oxidoreductase	Homo sapiens	200-203
22697787-4	2012	The next step is nucleophilic attack on the carbonyl carbon of EPX by the negatively charged Thr1-O(gamma) atom, followed by a proton transfer from Thr1-N(z) to the carbonyl oxygen of EPX (third step).	Oxygen	174-180	thyroid hormone receptor beta	Homo sapiens	93-97
22697787-4	2012	The next step is nucleophilic attack on the carbonyl carbon of EPX by the negatively charged Thr1-O(gamma) atom, followed by a proton transfer from Thr1-N(z) to the carbonyl oxygen of EPX (third step).	Oxygen	174-180	thyroid hormone receptor beta	Homo sapiens	148-152
22577939-0	2012	Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration.	Oxygen	53-59	cytoglobin	Homo sapiens	36-46
22577939-4	2012	Cygb is expressed in the vascular wall and can consume NO in an O(2)-dependent manner.	Oxygen	64-68	cytoglobin	Homo sapiens	0-4
22577939-6	2012	This kinetic model expresses the relationship between the rate of O(2)-dependent consumption of NO by Cygb and rate constants of the molecular reactions involved.	Oxygen	66-70	cytoglobin	Homo sapiens	102-106
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytoglobin	Homo sapiens	82-86
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytochrome p450 oxidoreductase	Homo sapiens	171-198
22577939-7	2012	The predicted rate of O(2)-dependent consumption of NO by Cygb is consistent with experimental results supporting the validity of the kinetic model.	Oxygen	22-26	cytoglobin	Homo sapiens	58-62
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytochrome p450 oxidoreductase	Homo sapiens	200-203
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytoglobin	Homo sapiens	232-236
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	245-249	cytoglobin	Homo sapiens	76-80
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytochrome p450 oxidoreductase	Homo sapiens	258-261
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytoglobin	Homo sapiens	232-236
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	46-50	cytoglobin	Homo sapiens	232-236
22577939-5	2012	Therefore, we characterize the process of the O(2)-dependent consumption of NO by Cygb in the presence of the cellular reductants and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constants of Cygb reduction by Asc and CPR, and propose a reaction mechanism and derive a related kinetic model for this O(2)-dependent NO consumption involving Cygb(Fe(3+)) as the main intermediate reduced back to ferrous Cygb by cellular reductants.	Oxygen	340-344	cytoglobin	Homo sapiens	82-86
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	245-249	cytoglobin	Homo sapiens	152-156
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	245-249	cytoglobin	Homo sapiens	152-156
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	346-350	cytoglobin	Homo sapiens	76-80
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	346-350	cytoglobin	Homo sapiens	152-156
22577939-8	2012	Simulations based on this kinetic model suggest that the high efficiency of Cygb in regulating the NO consumption rate is due to the rapid reduction of Cygb by cellular reductants, which greatly increases the rate of consumption of NO at higher O(2) concentrations, and binding of NO to Cygb, which reduces the rate of consumption of NO at lower O(2) concentrations.	Oxygen	346-350	cytoglobin	Homo sapiens	152-156
22577939-9	2012	Thus, the coexistence of Cygb with efficient reductants in tissues allows Cygb to function as an O(2)-dependent regulator of NO decay.	Oxygen	97-101	cytoglobin	Homo sapiens	25-29
22577939-9	2012	Thus, the coexistence of Cygb with efficient reductants in tissues allows Cygb to function as an O(2)-dependent regulator of NO decay.	Oxygen	97-101	cytoglobin	Homo sapiens	74-78
22698140-8	2012	Oxygen consumption was increased in the Mgat2-deficient mice when maintained on an HFD.	Oxygen	0-6	monoacylglycerol O-acyltransferase 2	Mus musculus	40-45
22532167-3	2012	Deoxynyboquinone lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).	Oxygen	87-93	NAD(P)H quinone dehydrogenase 1	Homo sapiens	37-41
22521743-1	2012	Catalase, an antioxidant and hydroperoxidase enzyme protects the cellular environment from harmful effects of hydrogen peroxide by facilitating its degradation to oxygen and water.	Oxygen	163-169	catalase	Homo sapiens	0-8
22715327-5	2012	Recent optogenetic experiments combined with functional magnetic resonance imaging have revealed that light stimulation of neurons expressing the calcium binding protein parvalbumin (PV) is associated with positive blood oxygen level-dependent (BOLD) signal in the corresponding barrel field but also with negative BOLD in the surrounding deeper area.	Oxygen	221-227	parvalbumin	Mus musculus	170-181
22514282-4	2012	We now demonstrate recombinant JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe(2+)-, 2-OG-, and O(2)-dependent manner.	Oxygen	119-123	protein arginine methyltransferase 5	Homo sapiens	31-35
22578081-9	2012	Under the low nutrient and low oxygen conditions (1% O(2) and 1% FBS), bFGF enhanced MSC survival and differentiation in the hydrogel.	Oxygen	31-37	fibroblast growth factor 2	Homo sapiens	71-75
22514282-10	2012	The influence of environment upon J biosynthesis via oxygen-sensitive regulation of JBP1/2 has exciting implications for the regulation of gene expression and parasite adaptation to different host niches.	Oxygen	53-59	protein arginine methyltransferase 5	Homo sapiens	84-90
22672319-0	2012	High dose erythropoietin increases brain tissue oxygen tension in severe vasospasm after subarachnoid hemorrhage.	Oxygen	48-54	erythropoietin	Homo sapiens	10-24
22437427-9	2012	60% reduction in the amount of hydrogen peroxide (H(2)O(2)) generated by Cu(2+)-Abeta in the presence of dioxygen (O(2)) and a reducing agent.	Oxygen	105-113	amyloid beta precursor protein	Homo sapiens	80-85
22437427-9	2012	60% reduction in the amount of hydrogen peroxide (H(2)O(2)) generated by Cu(2+)-Abeta in the presence of dioxygen (O(2)) and a reducing agent.	Oxygen	54-58	amyloid beta precursor protein	Homo sapiens	80-85
22243719-7	2012	There was a significant O(2) -dependent increase in the secretion of IL-10 (P &lt; 0.01) and decrease in TNFalpha/IL-10 ratio (P &lt; 0.005) in the culture medium in both groups.	Oxygen	24-28	tumor necrosis factor	Homo sapiens	105-113
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Oxygen	272-278	vascular endothelial growth factor A	Homo sapiens	129-134
22521302-0	2012	MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy.	Oxygen	120-126	myocyte enhancer factor 2C	Mus musculus	0-5
22521302-6	2012	However, MEF2C ablation in ECs suppressed vessel loss in oxygen-induced retinopathy and strongly promoted vascular regrowth, consequently reducing retinal avascularity.	Oxygen	57-63	myocyte enhancer factor 2C	Mus musculus	9-14
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Oxygen	272-278	nitric oxide synthase 3	Homo sapiens	139-143
22389426-11	2012	The results indicate that PACAP causes transactivation of the EGFR in NSCLC cells in an oxygen-dependent manner that involves phospholipase C but not protein kinase A.	Oxygen	88-94	epidermal growth factor receptor	Homo sapiens	62-66
22360728-2	2012	Cells recognize and respond to hypoxia by accumulation of the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of an oxygen-sensitive HIF-1alpha and a constitutive HIF-1beta subunit.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-109
22360728-2	2012	Cells recognize and respond to hypoxia by accumulation of the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of an oxygen-sensitive HIF-1alpha and a constitutive HIF-1beta subunit.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-116
22360728-2	2012	Cells recognize and respond to hypoxia by accumulation of the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of an oxygen-sensitive HIF-1alpha and a constitutive HIF-1beta subunit.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
22626901-17	2012	Young age at BCPC, high preoperative oxygen saturation and smaller PAs are associated with increased SPC flow, which may promote increased postoperative pleural drainage and lengthen recovery.	Oxygen	37-43	proline rich protein gene cluster	Homo sapiens	101-104
22612944-12	2012	The amount of HSPA1A mRNA was less for morulae that were heat shocked than for 2-cell embryos cultured at 38.5 C. Heat shock at a temperature and oxygen tension similar to those seen in vivo can disrupt developmental competence of bovine zygotes.	Oxygen	146-152	heat shock 70 kDa protein 1B	Bos taurus	14-20
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	70-76	erythropoietin	Homo sapiens	43-57
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	70-76	erythropoietin	Homo sapiens	59-62
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	78-80	erythropoietin	Homo sapiens	43-57
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	78-80	erythropoietin	Homo sapiens	59-62
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	99-105	erythropoietin	Homo sapiens	43-57
22828812-1	2012	BACKGROUND: A novel approach to increasing erythropoietin (EPO) using oxygen (O2) (the "normobaric oxygen paradox") has been reported in healthy volunteers.	Oxygen	99-105	erythropoietin	Homo sapiens	59-62
22652785-4	2012	Several studies found that many factors, including hormone levels, osmotic pressure, temperature, and oxygen concentration, regulate expression of AQPs in placenta, fetal membranes, and other mammalian organs through several signal transduction pathways, such as the cAMP, the MAPK, the PI3K/AKT, and the PKC pathways.	Oxygen	102-108	AKT serine/threonine kinase 1	Homo sapiens	292-295
22781821-6	2012	LPO, inhibition of Mn-SOD and complex III activities were more pronounced when inhaled oxygen was partially enriched with superoxide radical.	Oxygen	87-93	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	19-25
22781821-7	2012	In contrast, when O(2) was enriched with oxygen cation (O(2) +), LPO and loss of Mn-SOD activity were prevented.	Oxygen	41-47	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	81-87
22472608-1	2012	Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1alpha (Hif-1alpha) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-200
22472608-1	2012	Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1alpha (Hif-1alpha) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	202-212
22472608-1	2012	Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1alpha (Hif-1alpha) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses.	Oxygen	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	218-261
22472608-1	2012	Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1alpha (Hif-1alpha) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses.	Oxygen	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
21875341-6	2012	After 3 days in suspension culture as embryoid bodies (EBs), 2% O(2) caused the activation of hypoxia inducible factor responsive genes VEGF and LDHA and was accompanied by elevated expression levels of the early eye field genes Six3 and Lhx2.	Oxygen	64-68	vascular endothelial growth factor A	Homo sapiens	136-140
22490611-0	2012	Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-kappaB activation in a cerebral ischemia mouse model.	Oxygen	123-129	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-147
22540931-7	2012	Interestingly, when the astrocytes were exposed to severe hypoxia (0.1% O2), the altered cell morphology was ameliorated with up-regulation of HIF-1alpha.	Oxygen	72-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-153
21875341-6	2012	After 3 days in suspension culture as embryoid bodies (EBs), 2% O(2) caused the activation of hypoxia inducible factor responsive genes VEGF and LDHA and was accompanied by elevated expression levels of the early eye field genes Six3 and Lhx2.	Oxygen	64-68	lactate dehydrogenase A	Homo sapiens	145-149
21875341-6	2012	After 3 days in suspension culture as embryoid bodies (EBs), 2% O(2) caused the activation of hypoxia inducible factor responsive genes VEGF and LDHA and was accompanied by elevated expression levels of the early eye field genes Six3 and Lhx2.	Oxygen	64-68	SIX homeobox 3	Homo sapiens	229-233
22552282-7	2012	Low-oxygen-induced MULE expression in JEG3 choriocarcinoma cells was abolished by hypoxia-inducible factor (HIF)-1alpha siRNA.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-119
22481312-1	2012	We present a molecular level description of NO3  NO + O2 photodissociation for both of the experimentally observed reaction pathways using the results of ion imaging experiments and recent theoretical studies.	Oxygen	54-56	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
22678294-3	2012	Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (mTOR)-dependent mechanisms.	Oxygen	4-10	mechanistic target of rapamycin kinase	Homo sapiens	94-123
22678294-3	2012	Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (mTOR)-dependent mechanisms.	Oxygen	4-10	mechanistic target of rapamycin kinase	Homo sapiens	125-129
22678294-7	2012	We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.	Oxygen	77-83	RNA binding motif protein 4	Homo sapiens	164-168
22824280-8	2012	This analysis points to coupled conformational changes in CcO and their potential to influence both proton and oxygen access.	Oxygen	111-117	ryanodine receptor 1	Homo sapiens	58-61
21967640-6	2012	In response to stress signals, traffic of pro- and antiapoptotic mitochondrial proteins in the intermembrane space (B-cell lymphoma-extra large, Bcl-2-associated death promoter, Bcl-2 associated X-protein and cytochrome c) is modulated by the redox condition determined by mitochondrial O2 utilization and mitochondrial nitric oxide metabolism.	Oxygen	287-289	BCL2 apoptosis regulator	Homo sapiens	145-150
21967640-6	2012	In response to stress signals, traffic of pro- and antiapoptotic mitochondrial proteins in the intermembrane space (B-cell lymphoma-extra large, Bcl-2-associated death promoter, Bcl-2 associated X-protein and cytochrome c) is modulated by the redox condition determined by mitochondrial O2 utilization and mitochondrial nitric oxide metabolism.	Oxygen	287-289	BCL2 apoptosis regulator	Homo sapiens	178-183
22261596-7	2012	RESULTS: The 100% oxygen treatment significantly decreased the serum level of TNF-alpha and increased the serum level of IL-10.	Oxygen	18-24	tumor necrosis factor	Mus musculus	78-87
22261596-7	2012	RESULTS: The 100% oxygen treatment significantly decreased the serum level of TNF-alpha and increased the serum level of IL-10.	Oxygen	18-24	interleukin 10	Mus musculus	121-126
22451659-2	2012	Moreover, oxygen-dependent turnover of HIF-1alpha in these cells is controlled by the prolyl-4-hydroxylase domain (PHD) family of proteins.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
22451659-8	2012	Finally, loss of function studies using lentiviral transduction of ShPHDs clearly shows that even at 1% O(2), PHD2 selectively degrades HIF-1alpha.	Oxygen	104-108	egl-9 family hypoxia inducible factor 1	Homo sapiens	110-114
22574892-4	2012	The activation of NF-kappaB in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O2 consumption as well as lower heat production and body temperature in comparison to healthy peers.	Oxygen	188-190	nuclear factor kappa B subunit 1	Homo sapiens	18-27
22552282-11	2012	These data demonstrate that oxygen regulates Mcl-1 and p53 stability during placentation via HIF-1-controlled MULE expression.	Oxygen	28-34	tumor protein p53	Homo sapiens	55-58
22283926-5	2012	RESULTS: Histamine-induced itch compared with saline resulted in significant area under the curve blood oxygen level dependent (BOLD) signal changes in the middle/superior temporal gyrus and right inferior frontal gyrus/insula.	Oxygen	104-110	itchy E3 ubiquitin protein ligase	Homo sapiens	27-31
21254897-3	2012	Activation of the classical, alternative, and lectin complement pathways and the generation of the anaphylatoxins C3a and C5a lead to recruitment of polymorphonuclear leukocytes, generation of radical oxygen species, up-regulation of adhesion molecules on the endothelium and platelets, and induction of cytokine release.	Oxygen	201-207	complement C5a receptor 1	Homo sapiens	122-125
22691784-1	2012	The superoxide dismutase (SOD) family of proteins are necessary to protect oxygen-utilizing cells from the toxicity of reactive oxygen species.	Oxygen	75-81	superoxide dismutase 1	Homo sapiens	4-24
22691784-1	2012	The superoxide dismutase (SOD) family of proteins are necessary to protect oxygen-utilizing cells from the toxicity of reactive oxygen species.	Oxygen	75-81	superoxide dismutase 1	Homo sapiens	26-29
22352680-0	2012	The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs.	Oxygen	112-118	natriuretic peptide B	Canis lupus familiaris	40-65
22369766-9	2012	The mean ventilatory response was 5.8 litre min(-2) starting from air breathing and 4.5 litre min(-2) with oxygen breathing.	Oxygen	107-113	CD59 molecule (CD59 blood group)	Homo sapiens	94-100
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c, somatic	Homo sapiens	182-194
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c, somatic	Homo sapiens	182-194
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c, somatic	Homo sapiens	19-31
22311417-2	2012	Oxidative stress causes increased oxygen consumption in type 1 diabetic kidneys, partly mediated by uncoupling protein-2 (UCP-2)-induced mitochondrial uncoupling.	Oxygen	34-40	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	100-120
22172637-1	2012	BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-44
22172637-1	2012	BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	117-123	vascular endothelial growth factor A	Homo sapiens	148-182
22172637-1	2012	BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	117-123	vascular endothelial growth factor A	Homo sapiens	184-188
22172637-1	2012	BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	117-123	erythropoietin	Homo sapiens	194-208
22311417-2	2012	Oxidative stress causes increased oxygen consumption in type 1 diabetic kidneys, partly mediated by uncoupling protein-2 (UCP-2)-induced mitochondrial uncoupling.	Oxygen	34-40	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	122-127
22311417-3	2012	The present study investigates the role of UCP-2 and oxidative stress in mitochondrial oxygen consumption and kidney function in db/db mice as a model of type 2 diabetes.	Oxygen	87-93	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	43-48
22311417-9	2012	CONCLUSIONS/INTERPRETATION: db/db mice displayed oxidative stress-mediated activation of UCP-2, which resulted in mitochondrial uncoupling and increased oxygen consumption.	Oxygen	153-159	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	89-94
22344702-3	2012	In the present study, we show that inactivation of CYP3A4 by BG results in formation of a modified apoprotein-3A4 and a GSH conjugate, both exhibiting mass increases of 388 Da, which corresponds to the mass of 6",7"-dihydroxybergamottin (DHBG), a metabolite of BG, plus one oxygen atom.	Oxygen	274-280	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57
22539295-6	2012	The chemokine receptor CCR7 was expressed at higher levels in wild-type DCs compared with HIF1alpha-deficient DCs, whereas the production of CCL17 and CCL22 was increased in conditions of low oxygen.	Oxygen	192-198	chemokine (C-C motif) receptor 7	Mus musculus	23-27
22385418-0	2012	Controlled oxygen reperfusion protects the lung against early ischemia-reperfusion injury in cardiopulmonary bypasses by downregulating high mobility group box 1.	Oxygen	11-17	high mobility group box 1	Canis lupus familiaris	136-161
22385418-9	2012	After lung IR injury, HMGB1 mRNA and protein expressions were significantly decreased in the controlled oxygen group (all P &lt; .001).	Oxygen	104-110	high mobility group box 1	Canis lupus familiaris	22-27
22385418-10	2012	Controlled oxygen reperfusion is protective in the early stages of lung IR injury in a canine CPB model, and this protection is linked to HMGB1 downregulation.	Oxygen	11-17	high mobility group box 1	Canis lupus familiaris	138-143
22539295-6	2012	The chemokine receptor CCR7 was expressed at higher levels in wild-type DCs compared with HIF1alpha-deficient DCs, whereas the production of CCL17 and CCL22 was increased in conditions of low oxygen.	Oxygen	192-198	chemokine (C-C motif) ligand 17	Mus musculus	141-146
22539295-6	2012	The chemokine receptor CCR7 was expressed at higher levels in wild-type DCs compared with HIF1alpha-deficient DCs, whereas the production of CCL17 and CCL22 was increased in conditions of low oxygen.	Oxygen	192-198	chemokine (C-C motif) ligand 22	Mus musculus	151-156
22335188-2	2012	Endothelin-1 (ET-1) contributes to impaired autoregulation via oxygen (O2-) after TBI in piglets, but its relative role in males compared with females has not been previously investigated.	Oxygen	63-69	endothelin 1	Homo sapiens	0-12
22321729-1	2012	Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes.	Oxygen	40-46	erythropoietin	Homo sapiens	0-14
22321729-1	2012	Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes.	Oxygen	40-46	erythropoietin	Homo sapiens	16-19
22403348-9	2012	H(2)S in 21% O(2) increased Akt-P(Ser473) and GSK-3beta-P(Ser9) in the heart whereas phosphorylation was decreased by H(2)S in 10.5% O(2), indicating O(2) dependence in regulating cardiac signaling pathways.	Oxygen	13-17	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
22403352-9	2012	Pulsatile flow was not associated with augmentation of free hemoglobin production and was paralleled by improved oxygen consumption from 70 +- 14 to 82 +- 16 ml min(-1) m(-2) (P = 0.01) at the end of aortic cross-clamping.	Oxygen	113-119	CD59 molecule (CD59 blood group)	Homo sapiens	161-167
22335456-7	2012	A convergent pathway for the regulation of multiple modalities involved in O2 sensing is the mitogen activated protein kinase (p42/44 MAPK) or (ERK1/2 extracellular signal-regulated kinases) pathway terminating in a variety of transcription factors, for example, hypoxia-inducible factor 1alpha.	Oxygen	75-77	mitogen-activated protein kinase 1	Homo sapiens	127-138
22335456-7	2012	A convergent pathway for the regulation of multiple modalities involved in O2 sensing is the mitogen activated protein kinase (p42/44 MAPK) or (ERK1/2 extracellular signal-regulated kinases) pathway terminating in a variety of transcription factors, for example, hypoxia-inducible factor 1alpha.	Oxygen	75-77	mitogen-activated protein kinase 3	Homo sapiens	144-150
22335456-7	2012	A convergent pathway for the regulation of multiple modalities involved in O2 sensing is the mitogen activated protein kinase (p42/44 MAPK) or (ERK1/2 extracellular signal-regulated kinases) pathway terminating in a variety of transcription factors, for example, hypoxia-inducible factor 1alpha.	Oxygen	75-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	263-294
22335188-2	2012	Endothelin-1 (ET-1) contributes to impaired autoregulation via oxygen (O2-) after TBI in piglets, but its relative role in males compared with females has not been previously investigated.	Oxygen	63-69	endothelin 1	Homo sapiens	14-18
22335188-2	2012	Endothelin-1 (ET-1) contributes to impaired autoregulation via oxygen (O2-) after TBI in piglets, but its relative role in males compared with females has not been previously investigated.	Oxygen	71-73	endothelin 1	Homo sapiens	0-12
22335188-2	2012	Endothelin-1 (ET-1) contributes to impaired autoregulation via oxygen (O2-) after TBI in piglets, but its relative role in males compared with females has not been previously investigated.	Oxygen	71-73	endothelin 1	Homo sapiens	14-18
22033515-5	2012	Peak oxygen uptake (V O2peak) increased by ~35% from before (0.64 L min-1 or 11.4 mL kg min-1) to 1 month (0.88 L min-1 or 15.7 mL kg min-1) of treatment and did not significantly change thereafter.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
22033515-5	2012	Peak oxygen uptake (V O2peak) increased by ~35% from before (0.64 L min-1 or 11.4 mL kg min-1) to 1 month (0.88 L min-1 or 15.7 mL kg min-1) of treatment and did not significantly change thereafter.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
22033515-5	2012	Peak oxygen uptake (V O2peak) increased by ~35% from before (0.64 L min-1 or 11.4 mL kg min-1) to 1 month (0.88 L min-1 or 15.7 mL kg min-1) of treatment and did not significantly change thereafter.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
22033515-5	2012	Peak oxygen uptake (V O2peak) increased by ~35% from before (0.64 L min-1 or 11.4 mL kg min-1) to 1 month (0.88 L min-1 or 15.7 mL kg min-1) of treatment and did not significantly change thereafter.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
22051572-5	2012	Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp, peak oxygen uptake by a graded exercise test, and body composition by dual-energy x-ray absorptiometry.	Oxygen	76-82	insulin	Homo sapiens	0-7
22351759-4	2012	Runx2 also increased the nuclear translocation of HIF-1alpha when coexpressed in HEK293 cells and interacted with HIF-1alpha at the oxygen-dependent degradation domain (ODDD).	Oxygen	132-138	RUNX family transcription factor 2	Homo sapiens	0-5
22293863-6	2012	The MEK inhibitor decreased O2 - levels in ATO-treated             HPF cells whereas JNK and p38 inhibitors generally increased ROS levels including             O2 - in these cells.	Oxygen	161-163	mitogen-activated protein kinase 8	Homo sapiens	85-88
22293863-6	2012	The MEK inhibitor decreased O2 - levels in ATO-treated             HPF cells whereas JNK and p38 inhibitors generally increased ROS levels including             O2 - in these cells.	Oxygen	161-163	mitogen-activated protein kinase 14	Homo sapiens	93-96
22293863-6	2012	The MEK inhibitor decreased O2 - levels in ATO-treated             HPF cells whereas JNK and p38 inhibitors generally increased ROS levels including             O2 - in these cells.	Oxygen	28-30	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
22883037-1	2012	OBJECTIVE: To investigate the influence of high oxygen exposure on signaling pathway of the receptor for advanced glycation end products (RAGE)-NF-kappaB of lung in newborn rats and the mechanisms of protecting lung injury for human mesenchymal stem cells (hMSC).	Oxygen	48-54	advanced glycosylation end product-specific receptor	Rattus norvegicus	138-142
22351759-4	2012	Runx2 also increased the nuclear translocation of HIF-1alpha when coexpressed in HEK293 cells and interacted with HIF-1alpha at the oxygen-dependent degradation domain (ODDD).	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
22351759-4	2012	Runx2 also increased the nuclear translocation of HIF-1alpha when coexpressed in HEK293 cells and interacted with HIF-1alpha at the oxygen-dependent degradation domain (ODDD).	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
22539855-5	2012	Impairment of mitochondrial Ca2+ uptake was associated with increased mitochondrial reactive oxygen species and depolarization of mitochondrial membrane potential.	Oxygen	93-99	carbonic anhydrase 2	Mus musculus	28-31
22215442-7	2012	This was supported by our observations in parkin larvae that the resting potential was depolarized, oxygen consumption and ATP concentration were drastically reduced while lactate was increased.	Oxygen	100-106	parkin	Drosophila melanogaster	42-48
22455795-3	2012	The [NHC(H)][HCO(3)] salts were next shown to behave as masked NHCs, allowing for the NHC moiety to be readily transferred to both organic and organometallic substrates, without the need for dry and oxygen-free conditions.	Oxygen	199-205	high mobility group nucleosomal binding domain 4	Homo sapiens	5-8
22455795-3	2012	The [NHC(H)][HCO(3)] salts were next shown to behave as masked NHCs, allowing for the NHC moiety to be readily transferred to both organic and organometallic substrates, without the need for dry and oxygen-free conditions.	Oxygen	199-205	high mobility group nucleosomal binding domain 4	Homo sapiens	63-66
22338082-3	2012	In the present study, we characterized the antivascular endothelial growth factor (VEGF) effects of LMPs on pathological angiogenesis in an animal model of oxygen-induced retinopathy and explored the role of receptor-mediated endocytosis in the effects of LMPs on human retinal endothelial cells (HRECs).	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	83-87
22513875-8	2012	Thus, low glucose and oxygen conditions induce the UPR, generation of ROS, and expressed the Nrf2 and Nrf2-dependent antioxidant enzymes at normal levels.	Oxygen	22-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
22513875-8	2012	Thus, low glucose and oxygen conditions induce the UPR, generation of ROS, and expressed the Nrf2 and Nrf2-dependent antioxidant enzymes at normal levels.	Oxygen	22-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
22360297-3	2012	This study evaluates the association between S100beta, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo(2)).	Oxygen	210-216	S100 calcium binding protein B	Homo sapiens	45-53
22504483-4	2012	Metabolic studies uncovered a limited ability of ischemic hearts in Per2(-/-) mice to use carbohydrates for oxygen-efficient glycolysis.	Oxygen	108-114	period circadian clock 2	Mus musculus	68-72
22306110-0	2012	The effects of ROS-mediating oxygen tension on human CD34(+)CD38(-) cells induced into mature dendritic cells.	Oxygen	29-35	CD34 molecule	Homo sapiens	53-57
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Oxygen	170-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	0-12
21939634-6	2012	The reactions of interest are reviewed, with special attention to the molecular mechanisms underlying the effects of NO observed on cytochrome c oxidase, particularly during turnover with oxygen and reductants.	Oxygen	188-194	cytochrome c, somatic	Homo sapiens	132-144
22394372-2	2012	R(TMP) was inversely proportional to dioxygen concentration at [O(2)] &gt; 50 muM, a dependence consistent with reaction with triplet excited states, but not with (1)O(2) or RO(2).	Oxygen	37-45	latexin	Homo sapiens	78-81
22397317-0	2012	Oxidation of human growth hormone by oxygen-centered radicals: formation of Leu-101 hydroperoxide and Tyr-103 oxidation products.	Oxygen	37-43	growth hormone 1	Homo sapiens	19-33
22397317-1	2012	Human growth hormone (hGH) was exposed to oxygen-centered radicals generated through the thermolysis of AAPH in the presence of dioxygen.	Oxygen	128-136	growth hormone 1	Homo sapiens	6-20
22221948-6	2012	In the Fontan group, patients in the highest quartile of SPC flow had larger ventricular end-diastolic volume/BSA (p &lt;0.0001) and were older at the time of Fontan surgery (p = 0.04), but SPC flow/BSA was not associated with heart failure symptoms, atrial or ventricular arrhythmias, atrioventricular valve regurgitation, the ventricular ejection fraction, or peak oxygen consumption.	Oxygen	367-373	proline rich protein gene cluster	Homo sapiens	57-60
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	14-18
21771582-1	2012	Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water.	Oxygen	152-158	cytochrome c, somatic	Homo sapiens	24-36
22527961-0	2012	Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).	Oxygen	26-32	fms related receptor tyrosine kinase 3	Homo sapiens	150-176
22181812-1	2012	Hypoxia inducible factor-1alpha (HIF-1alpha) has a central role in cellular oxygen-sensing, and its overexpression in many types of cancer is considered important in tumor progression.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
22181812-1	2012	Hypoxia inducible factor-1alpha (HIF-1alpha) has a central role in cellular oxygen-sensing, and its overexpression in many types of cancer is considered important in tumor progression.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
22181812-3	2012	In normoxic conditions, HIF-1alpha is hydroxylated by oxygen-dependent prolyl-hydroxylases, which require ferrous iron for its activity.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
22221911-5	2012	Oxygen-uptake and inhibition studies with cell-free extracts displayed a change from cytochrome c to quinol as electron donor after exposure to oxygen.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	85-97
22221911-5	2012	Oxygen-uptake and inhibition studies with cell-free extracts displayed a change from cytochrome c to quinol as electron donor after exposure to oxygen.	Oxygen	144-150	cytochrome c, somatic	Homo sapiens	85-97
22234382-0	2012	NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase zeta under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices.	Oxygen	114-120	diacylglycerol kinase zeta	Rattus norvegicus	81-107
21604266-7	2012	Alkaline phosphatase activity and RNA expression as well as RUNX2 expression were significantly reduced under 2% oxygen.	Oxygen	113-119	RUNX family transcription factor 2	Homo sapiens	60-65
22527961-0	2012	Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).	Oxygen	26-32	fms related receptor tyrosine kinase 3	Homo sapiens	178-182
21895822-9	2012	All inflammatory markers except MPO correlated to AHI and oxygen desaturation measures, and to waist circumference.	Oxygen	58-64	myeloperoxidase	Homo sapiens	32-35
21895822-10	2012	In multiple linear regressions adjusting for age, waist circumference and smoking, independent correlations between oxygen desaturation indices (ODI) and inflammation were found for IL-6 (P = 0.03 for % sleep time with saturation &lt;90%) and TNFalpha (P = 0.03 for ODI 3%).	Oxygen	116-122	interleukin 6	Homo sapiens	182-186
22124351-2	2012	OBJECTIVES: To determine whether leg vascular occlusion (LEVO) augment arm cycling (ACE) peak oxygen uptake in spinal cord-injured individuals.	Oxygen	94-100	angiotensin I converting enzyme	Homo sapiens	84-87
22458830-6	2012	HSP72 under normoxia followed the established trend; however, following the hyperbaric air or oxygen exposure a reduction in detectable HSP72 was observed at 17:00 and 21:00.	Oxygen	94-100	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
22458830-6	2012	HSP72 under normoxia followed the established trend; however, following the hyperbaric air or oxygen exposure a reduction in detectable HSP72 was observed at 17:00 and 21:00.	Oxygen	94-100	heat shock protein family A (Hsp70) member 1A	Homo sapiens	136-141
22395314-3	2012	Three HIF prolyl hydroxylase enzymes (PHD1, PHD2 and PHD3) function as oxygen sensing enzymes, which regulate the activity of HIFs in normoxic and hypoxic conditions.	Oxygen	71-77	egl-9 family hypoxia inducible factor 1	Homo sapiens	44-48
22325888-0	2012	Ubiquitin/proteasome-mediated proteolysis is involved in the response to flooding stress in soybean roots, independent of oxygen limitation.	Oxygen	122-128	polyubiquitin	Glycine max	0-9
22011014-2	2012	The results presented here demonstrate that constructs cultured under hypoxic conditions with insulin supplementation increased in collagen density by approximately five-fold and both the ultimate tensile strength (UTS) and modulus by more than three-fold compared with normoxic (20% oxygen tension), noninsulin supplemented controls.	Oxygen	284-290	insulin	Homo sapiens	94-101
22414879-3	2012	Two schemes have been proposed for oxygen action--one involving a cytochrome P450 hemoprotein (sensor)/endothelin-1 (effector) complex and the other a set of voltage-gated K(+) channels.	Oxygen	35-41	endothelin 1	Homo sapiens	103-115
22113497-11	2012	In vivo, chronic exposure of mice to a normobaric atmosphere of 10% oxygen increased lung tissue expression of mRNA encoding MIF and accumulation of MIF in plasma.	Oxygen	68-74	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	125-128
22113497-11	2012	In vivo, chronic exposure of mice to a normobaric atmosphere of 10% oxygen increased lung tissue expression of mRNA encoding MIF and accumulation of MIF in plasma.	Oxygen	68-74	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	149-152
22411802-3	2012	In this study, we combined magnetic resonance spectroscopy ((1)H-MRS) and functional magnetic resonance imaging (fMRI), finding that interindividual differences of glutamate levels in the dACC during resting-state predict the strength of the blood-oxygen level-dependent (BOLD) response to a task requiring cognitive control.	Oxygen	248-254	Acetyl-CoA carboxylase	Drosophila melanogaster	188-192
22385473-6	2012	Primary ONIOM (DFT:UFF) calculations, which were performed to investigate the effect of the competitive coordination of (S)-induction agent versus cyclohexene oxide to Co(III) center on enantioselectivity, suggest that the (S)-C-O bond in cyclohexene oxide is more favorable for cleavage, due to the interaction between oxygen atom of (S)-induction agent and (S)-C-H of the coordinated cyclohexene oxide.	Oxygen	320-326	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	168-175
22263529-4	2012	The oxygen removal system consists of an oxidase enzyme, an oxidase-specific substrate, and catalase for dismutation of hydrogen peroxide generated in the enzyme catalyzed oxygen removal reaction.	Oxygen	4-10	catalase	Homo sapiens	57-100
22252129-6	2012	Instead, EGL-9 interacts with the Mint orthologue LIN-10, a mediator of GLR-1 membrane recycling, to promote LIN-10 subcellular localization in an oxygen-dependent manner.	Oxygen	147-153	Protein lin-10	Caenorhabditis elegans	50-56
22252129-6	2012	Instead, EGL-9 interacts with the Mint orthologue LIN-10, a mediator of GLR-1 membrane recycling, to promote LIN-10 subcellular localization in an oxygen-dependent manner.	Oxygen	147-153	Protein lin-10	Caenorhabditis elegans	109-115
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Oxygen	203-209	Protein lin-10	Caenorhabditis elegans	149-155
22419111-5	2012	Accordingly, Tat decreases substrate oxidation by mitochondria isolated from these tissues, with oxygen uptake being initially restored by adding cytochrome c.	Oxygen	97-103	cytochrome c, somatic	Homo sapiens	146-158
22419115-7	2012	The oxygen-mediated rescue of mutant p53 followed by its trans-activation is responsible for the induction of p53-downstream apoptotic, cell-cycle arrest and DNA-repair genes.	Oxygen	4-10	tumor protein p53	Homo sapiens	37-40
22419115-7	2012	The oxygen-mediated rescue of mutant p53 followed by its trans-activation is responsible for the induction of p53-downstream apoptotic, cell-cycle arrest and DNA-repair genes.	Oxygen	4-10	tumor protein p53	Homo sapiens	110-113
22419115-9	2012	We have thus concluded that oxygen therapy without pressure, as opposed to HBO therapy, may be ideal for hypoxic tumor regression, which functions through oxygen-mediated rescue of mutant p53 followed by induction of apoptosis.	Oxygen	28-34	tumor protein p53	Homo sapiens	188-191
22419115-9	2012	We have thus concluded that oxygen therapy without pressure, as opposed to HBO therapy, may be ideal for hypoxic tumor regression, which functions through oxygen-mediated rescue of mutant p53 followed by induction of apoptosis.	Oxygen	155-161	tumor protein p53	Homo sapiens	188-191
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Oxygen	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Oxygen	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-4	2012	The active species to react with O(2) in the catalytic reaction is switched from Co(II)(Ph(8)Pc) to protonated Co(I)(Ph(8)PcH), depending on the reducing ability of ferrocene derivatives employed.	Oxygen	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22411794-2	2012	Here we identify CAV1 as a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor within the confined surface area of caveolae and its subsequent phosphorylation in the absence of ligand.	Oxygen	60-66	caveolin 1	Homo sapiens	17-21
22393014-9	2012	Csb is a multifunctional protein regulating both repair and the transcriptional response to reactive oxygen through its interaction with histone acetylase p300 and the hypoxia-inducible factor (HIF)1 pathway.	Oxygen	101-107	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	0-3
22416235-6	2012	RESULTS: Mean peak oxygen uptake [Formula: see text] increased from 34 +- 7 to 37 +- 7 ml kg(-1) min(-1) in training group (p &lt; 0.001) and did not change in control group (from 34 +- 7 to 34 +- 7 ml kg(-1) min(-1)).	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	97-103
22342667-2	2012	Evidence suggests that cytochrome c and vitamin C function as a redox relay for diffusible reduced oxygen species in the reaction system, without invoking specific or affinity-based molecular interactions for electron transfers.	Oxygen	99-105	cytochrome c, somatic	Homo sapiens	23-35
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22394569-9	2012	In patients with PM and DM with ILD, serum CX3CL1 was also correlated with alveolar-arterial oxygen pressure difference.	Oxygen	93-99	C-X3-C motif chemokine ligand 1	Homo sapiens	43-49
22253436-3	2012	The stability of FBXL5 is regulated in an iron- and oxygen-responsive manner, contingent upon the presence of its N-terminal domain.	Oxygen	52-58	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
22263529-4	2012	The oxygen removal system consists of an oxidase enzyme, an oxidase-specific substrate, and catalase for dismutation of hydrogen peroxide generated in the enzyme catalyzed oxygen removal reaction.	Oxygen	172-178	catalase	Homo sapiens	57-100
22210751-7	2012	The work to exhaustion (vertical distance x body weight) and peak oxygen uptake were significantly decreased in ANG II compared with vehicle.	Oxygen	66-72	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	112-118
22205687-6	2012	The degradation and activity of HIF-1alpha and HIF-2alpha are tightly controlled by the fine-tuned action of oxygen-sensing prolyl and asparaginyl hydroxylase enzymes.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
22246635-2	2012	This study shows that dissimilatory nitrate reduction to ammonium (DNRA) process, where nitrogen is not removed but instead recycled in the system, dominates nitrate reduction in low oxygen conditions (O(2) &lt;110 muM), which have been persistent in the central Gulf of Finland during the past decade.	Oxygen	183-189	latexin	Homo sapiens	215-218
21638206-9	2012	Hypoxia-inducible factor-3alpha mRNA was up-regulated in these cultures in response to low oxygen tension.	Oxygen	91-97	hypoxia inducible factor 3 subunit alpha	Homo sapiens	0-31
22058205-10	2012	Increased vascular endothelial growth factor-A secretion by mesenchymal stromal cells under low oxygen conditions, which increased the permeability of the monolayer, was responsible for this effect.	Oxygen	96-102	vascular endothelial growth factor A	Homo sapiens	10-46
22058205-11	2012	Furthermore, vascular endothelial growth factor-A expression in low oxygen mesenchymal stromal cells was induced via hypoxia-inducible factor signaling.	Oxygen	68-74	vascular endothelial growth factor A	Homo sapiens	13-49
22207131-5	2012	We primed naive CD4(+) T cells under 5% O(2), which has been observed in the lymph node or spleen and reoxygenated under normoxia that mimicked the O(2) concentration in blood.	Oxygen	40-44	CD4 molecule	Homo sapiens	16-19
21904933-9	2012	In Laks, a non-synonymous variant within HIF1A already known to be associated with improvement in oxygen metabolism was rediscovered, and in Kubachians a cluster of 13 SNPs located in a conserved intronic region within EGLN1 showing high population differentiation was found.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-46
21904933-9	2012	In Laks, a non-synonymous variant within HIF1A already known to be associated with improvement in oxygen metabolism was rediscovered, and in Kubachians a cluster of 13 SNPs located in a conserved intronic region within EGLN1 showing high population differentiation was found.	Oxygen	98-104	egl-9 family hypoxia inducible factor 1	Homo sapiens	219-224
22207131-7	2012	Under the condition of 5% O(2), mammalian target of rapamycin complex 1 (mTORC1) was activated and led to the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) in T(h)17 cells.	Oxygen	26-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
22207131-7	2012	Under the condition of 5% O(2), mammalian target of rapamycin complex 1 (mTORC1) was activated and led to the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) in T(h)17 cells.	Oxygen	26-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-158
24627673-1	2012	OBJECTIVE: Hypoxia inducible factor 1 alpha (HIF-1alpha) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-43
24627673-1	2012	OBJECTIVE: Hypoxia inducible factor 1 alpha (HIF-1alpha) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
22219185-4	2012	FHL1-3 inhibit HIF-1 transcriptional activity and HIF-1alpha transactivation domain function by oxygen-independent mechanisms.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
22198287-4	2012	In this study, we found that temporary exposure of rBMSCs after osteogenic induction for 7 days to hypoxia (2% oxygen) led to a marked decrease in ALPase activity and the expression of osteocalcin and Runt related transcription factor 2/core binding factor a1 (Runx2/Cbfa1).	Oxygen	111-117	bone gamma-carboxyglutamate protein	Rattus norvegicus	185-196
22198287-4	2012	In this study, we found that temporary exposure of rBMSCs after osteogenic induction for 7 days to hypoxia (2% oxygen) led to a marked decrease in ALPase activity and the expression of osteocalcin and Runt related transcription factor 2/core binding factor a1 (Runx2/Cbfa1).	Oxygen	111-117	RUNX family transcription factor 2	Rattus norvegicus	201-236
22198287-4	2012	In this study, we found that temporary exposure of rBMSCs after osteogenic induction for 7 days to hypoxia (2% oxygen) led to a marked decrease in ALPase activity and the expression of osteocalcin and Runt related transcription factor 2/core binding factor a1 (Runx2/Cbfa1).	Oxygen	111-117	RUNX family transcription factor 2	Rattus norvegicus	261-266
22198287-4	2012	In this study, we found that temporary exposure of rBMSCs after osteogenic induction for 7 days to hypoxia (2% oxygen) led to a marked decrease in ALPase activity and the expression of osteocalcin and Runt related transcription factor 2/core binding factor a1 (Runx2/Cbfa1).	Oxygen	111-117	RUNX family transcription factor 2	Rattus norvegicus	267-272
21110125-2	2012	Athletes either live or sleep in artificial or natural hypoxic conditions with the aim to increase serum erythropoietin concentrations, which are thought to improve maximum oxygen uptake and thus exercise performance.	Oxygen	173-179	erythropoietin	Homo sapiens	105-119
22737909-6	2012	CONCLUSION: Tibetan antelope may improve their ability to get oxygen under hypoxia by increasing the content of myoglobin in skeletal muscle, and the proportion of aerobic metabolism is high in skeletal muscle, it may be relate that with high myoglobin content in skeletal muscle, we suppose that high myoglobin content in skeletal muscle of tibetan antelope might be one of the molecular basis to adapt hypoxia.	Oxygen	62-68	myoglobin	Pantholops hodgsonii	112-121
22083267-1	2012	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation and controls genes involved in glycolysis, angiogenesis, migration and invasion.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
22083267-1	2012	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation and controls genes involved in glycolysis, angiogenesis, migration and invasion.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
22213097-0	2012	Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1alpha-notch signal interaction in the developing brain.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-114
22213097-3	2012	Here, we show that the oxygen sensor hypoxia-inducible factor 1alpha (HIF1alpha) plays a critical role in astrocytic gene demethylation in mgNPCs by cooperating with the Notch signaling pathway.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-68
22213097-3	2012	Here, we show that the oxygen sensor hypoxia-inducible factor 1alpha (HIF1alpha) plays a critical role in astrocytic gene demethylation in mgNPCs by cooperating with the Notch signaling pathway.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-79
22226677-2	2012	The kinetics of the oxygen atom transfer between [{MoO(2)(Bz(2)Benzenediyldtc)}(2)] and PPh(3) was studied spectrophotometrically in CH(2)Cl(2) medium at 520 nm and four different temperatures, 288, 293, 298 and 303 K, respectively.	Oxygen	20-26	caveolin 1	Homo sapiens	88-94
22226677-7	2012	Catalytic oxygen atom transfer reaction from DMSO to PPh(3) was also followed by monitoring the chemical shift changes in (31)P NMR spectroscopy.	Oxygen	10-16	caveolin 1	Homo sapiens	53-59
22318826-8	2012	CRP and arterial oxygen tension (PaO2) were significantly correlated with both serum VEGF (p=0.032 and p=0.016, respectively) and Ang-2 levels (p&lt;0.001 and p=0.041, respectively), after adjusting for other factors.	Oxygen	17-23	vascular endothelial growth factor A	Homo sapiens	85-89
21924301-8	2012	In most cases, substitution of carbon with nitrogen and oxygen was related to increased compound degradation in comparison to unalkylated and sulphur- or unsubstituted PAH with a similar ring number.The obtained results indicate that GC2/MS can be employed for the rapid assessment of a large variety of structurally heterogeneous environmental contaminants.	Oxygen	56-62	solute carrier family 25 member 18	Homo sapiens	234-237
22214241-2	2012	We examine the concentration and pressure of hydrogen gas as a function of temperature in which abstraction of oxygen is possible with minimum damage to C-sp(2) bonds, hence preserving the integrity of the graphene sheet.	Oxygen	111-117	regulator of calcineurin 2	Homo sapiens	153-160
22206978-13	2012	ROS EPR signals were completely eliminated when superoxide dismutase and catalase were included in the complete in vitro enzymatic system, providing additional proof of oxygen radical participation.	Oxygen	169-175	catalase	Homo sapiens	73-81
21792862-3	2012	PHD2 is considered the key oxygen sensor-regulating hypoxia-inducible factor (HIF).	Oxygen	27-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
22277279-6	2012	Our findings suggest that hCA VII could use the in vivo S-glutathionylation to function as an oxygen radical scavenger for protecting cells from oxidative damage, as the activity and affinity for inhibitors of the modified enzyme are similar to those of the wild type.	Oxygen	94-100	carbonic anhydrase 7	Homo sapiens	26-33
22004513-2	2012	Transcription factor hypoxia-inducible factor 1 (HIF-1) is known to respond to intracellular reduced oxygen (O(2)) availability, which is regulated by an elaborate balance between O(2) supply and demand.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
21923556-2	2012	RESULTS: Bone marrow Sca-1(+) cells were exposed to oxygen and glucose deprivation (OGD) for up to 12 h. Erk1/2 was activated in Sca-1(+) cells under OGD which was blocked by MEK inhibitor (PD98059) and resulted in accelerated cell death.	Oxygen	52-58	ataxin 1	Homo sapiens	21-26
21923556-2	2012	RESULTS: Bone marrow Sca-1(+) cells were exposed to oxygen and glucose deprivation (OGD) for up to 12 h. Erk1/2 was activated in Sca-1(+) cells under OGD which was blocked by MEK inhibitor (PD98059) and resulted in accelerated cell death.	Oxygen	52-58	mitogen-activated protein kinase 3	Homo sapiens	105-111
21923556-2	2012	RESULTS: Bone marrow Sca-1(+) cells were exposed to oxygen and glucose deprivation (OGD) for up to 12 h. Erk1/2 was activated in Sca-1(+) cells under OGD which was blocked by MEK inhibitor (PD98059) and resulted in accelerated cell death.	Oxygen	52-58	ataxin 1	Homo sapiens	129-134
22312113-10	2012	The experiments identify the single methyl group on the 2"-oxygen of G(m)18 as a natural modification in native tRNA that, beyond its primary structural role, has acquired a secondary function as an antagonist of TLR7.	Oxygen	59-65	toll like receptor 7	Homo sapiens	213-217
22004513-9	2012	INNOVATION: For the first time, we show that H(2)S modulates intracellular O(2) homeostasis and regulates activation of HIF-1 and the subsequent gene expression induced by hypoxia by using an in vitro system with established cell lines and an in vivo system in mice.	Oxygen	75-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-125
22004513-2	2012	Transcription factor hypoxia-inducible factor 1 (HIF-1) is known to respond to intracellular reduced oxygen (O(2)) availability, which is regulated by an elaborate balance between O(2) supply and demand.	Oxygen	109-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
22004513-2	2012	Transcription factor hypoxia-inducible factor 1 (HIF-1) is known to respond to intracellular reduced oxygen (O(2)) availability, which is regulated by an elaborate balance between O(2) supply and demand.	Oxygen	180-184	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
21771385-11	2012	Further study is warranted to examine tight glucose control with insulin therapy on postoperative systemic and cerebral oxygen transport and functional outcomes in neonates after cardiopulmonary bypass.	Oxygen	120-126	insulin	Homo sapiens	65-72
22143159-4	2012	The classic paradigm views MPO as a component of the phagocyte oxygen-dependent intracellular microbicidal system, and thus an important arm of the effector phase of innate immune responses.	Oxygen	63-69	myeloperoxidase	Homo sapiens	27-30
22339724-8	2012	Cross-linked Hb accelerates erythropoiesis by downregulating NF-kappa B, stabilizing and facilitating HIF-1 alpha binding to the EPO gene, under both oxygen conditions.	Oxygen	150-156	erythropoietin	Homo sapiens	129-132
22207007-2	2012	The deprotonated tolfenamato ligands are coordinated to Co(II) ion through carboxylato oxygen atoms.	Oxygen	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
22233504-6	2012	The expression of SPC in the group of high concentration of oxygen was significantly reduced on day 3.	Oxygen	60-66	surfactant protein C	Rattus norvegicus	18-21
22288477-9	2012	The ability of BDNF to modify brain metabolism and the efficiency of oxygen utilization via a MEK-Bcl-2 pathway may be an important component of the neuroprotective action observed with this neurotrophin.	Oxygen	69-75	B cell leukemia/lymphoma 2	Mus musculus	98-103
22088764-6	2012	The adsorbed Pb(II) and Cu(II) ions were in the form of the complex with oxygen in carboxyl and hydroxyl groups binding on the surface of magnetic porous MnFe(2)O(4).	Oxygen	73-79	submaxillary gland androgen regulated protein 3B	Homo sapiens	13-19
21987385-1	2012	Studies of many cell types show that levels of hypoxia inducible factor (HIF)-1alpha and HIF-2alpha are primarily controlled by oxygen-dependent proteasomal degradation, catalyzed by HIF prolyl-hydroxylases (PHDs).	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-84
22172337-5	2012	RESULTS: Exposure of LNCaP cells to low oxygen tension induced a neuroendocrine phenotype, associated with an increased expression of the transcription factor neurogenin3 and neuroendocrine markers, such as neuron-specific enolase, chromogranin A, and beta3-tubulin.	Oxygen	40-46	enolase 2	Homo sapiens	207-230
22178666-2	2012	The deprotonated naproxen acts as monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Oxygen	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
21820133-4	2012	Waist girth (centimeters) and fitness (milliliters of oxygen per kilogram of fat-free mass) were associated with high-density lipoprotein cholesterol, leptin, and insulin resistance after adjustment for age, saturated fat intake, and total energy intake.	Oxygen	54-60	insulin	Homo sapiens	163-170
22093255-2	2012	We hypothesized that iron chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as those involved with oxygen sensing and that similar inhibition may be observed with agents which simulate hypoxia.	Oxygen	134-140	vascular cell adhesion molecule 1	Homo sapiens	58-64
22308962-4	2012	The stability (for example, k-values) of L-5-MTHF in an oxygen controlled environment improved (P &lt; 0.001) proportionally when in the presence of increasing molar ratios of sodium ascorbate (NaAsc).	Oxygen	56-62	ribosomal protein L5	Homo sapiens	41-49
22172337-5	2012	RESULTS: Exposure of LNCaP cells to low oxygen tension induced a neuroendocrine phenotype, associated with an increased expression of the transcription factor neurogenin3 and neuroendocrine markers, such as neuron-specific enolase, chromogranin A, and beta3-tubulin.	Oxygen	40-46	chromogranin A	Homo sapiens	232-246
22054172-4	2012	Upon photoexcitation with white light (400-800 nm) with 90 and 45 mW cm(-2) for bacteria and cancer cells killing respectively, PBF nanoparticles can sensitize the oxygen molecule to readily produce reactive oxygen species (ROS) for rapidly killing neighboring bacteria and cancer cells.	Oxygen	164-170	PTTG1 interacting protein	Homo sapiens	128-131
20409610-2	2012	This review compiles the existing literature concerning the effects of APOE genotype on the blood oxygen level dependent (BOLD) response, measured during task-based functional magnetic resonance imaging.	Oxygen	98-104	apolipoprotein E	Homo sapiens	71-75
21988537-6	2012	Two different light-dependent reactive oxygen bursts in mitochondria play prominent and causal roles in the acd2 PCD phenotype.	Oxygen	39-45	accelerated cell death 2 (ACD2)	Arabidopsis thaliana	108-112
21791162-7	2012	GLUT1, G6PD and LDHA were up-regulated in cumulus cells that had been matured in low oxygen, suggesting a higher glucose uptake and an increase in anaerobic glycolysis, whereas cyclin B1 (CCNB) and MnSOD (Mn-superoxide dismutase) were upregulated in cumulus cells that had been matured in high oxygen, which suggests a higher activity of mitosis-promoting factor and antioxidant response.	Oxygen	85-91	lactate dehydrogenase A	Homo sapiens	16-20
22237207-6	2012	Here, we report that elevated oxygen (hyperoxia) triggers a marked increase in active caspase-2 expression, resulting in an initiation of the intrinsic apoptotic pathway with upregulation of key proteins, namely, cytochrome c, apoptosis protease-activating factor-1, and the caspase-independent protein apoptosis-inducing factor, whereas BH3-interacting domain death agonist and the anti-apoptotic protein B-cell lymphoma-2 are downregulated.	Oxygen	30-36	cytochrome c, somatic	Homo sapiens	213-225
22294712-0	2012	Letter by Lecoultre and Tam regarding article, "Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation".	Oxygen	73-79	insulin	Homo sapiens	138-145
22299875-0	2012	17O excess transfer during the NO2 + O3   NO3 + O2 reaction.	Oxygen	32-34	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
22142421-0	2012	EPR-ENDOR characterization of (17O, 1H, 2H) water in manganese catalase and its relevance to the oxygen-evolving complex of photosystem II.	Oxygen	97-103	catalase	Homo sapiens	63-71
22139840-10	2012	Pronounced abnormalities inherent in T4826I-RYR1 channels confer MHS and promote basal disturbances of excitation-contraction coupling, [Ca(2+)](rest), and oxygen consumption rates.	Oxygen	156-162	ryanodine receptor 1, skeletal muscle	Mus musculus	44-48
22147694-4	2012	WT p53 exists in mutant conformation in hypoxic core of MCF-7 solid tumors, and its conformation is oxygen-dependent.	Oxygen	100-106	tumor protein p53	Homo sapiens	3-6
22071158-8	2012	Finally, chronic induction of HO-1 increases oxygen consumption, CO(2), and heat production and activity in obese mice.	Oxygen	45-51	heme oxygenase 1	Mus musculus	30-34
22239663-0	2012	A distal pocket Leu residue inhibits the binding of O2 and NO at the distal heme site of cytochrome c".	Oxygen	52-54	cytochrome c, somatic	Homo sapiens	89-101
22265524-2	2012	Characterization studies revealed the presence of edge plane sites and surface carbon-oxygen functionalities at the surface of the CNP material.	Oxygen	86-92	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	131-134
22226148-11	2012	CONCLUSION: Downregulated StAR and 3-beta-HSD significantly contribute to low testosterone in hypoxic rats and is associated with ER stress which mediates testis damage caused by oxygen deprivation.	Oxygen	179-185	steroidogenic acute regulatory protein	Rattus norvegicus	26-30
22009797-2	2012	The latter is the oxygen-regulated subunit of HIF-1, the most important transcription factor of the cellular adaptive processes to hypoxic conditions.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-51
22009797-6	2012	Hypoxia (1% O(2)) or treatment with hypoxia-mimicking CoCl(2) enhanced RSUME and HIF-1alpha expression, induced translocation of HIF-1alpha to the nuclei and stimulated VEGF-A production both in pituitary tumour cell lines and primary human pituitary adenoma cell cultures.	Oxygen	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
22009797-6	2012	Hypoxia (1% O(2)) or treatment with hypoxia-mimicking CoCl(2) enhanced RSUME and HIF-1alpha expression, induced translocation of HIF-1alpha to the nuclei and stimulated VEGF-A production both in pituitary tumour cell lines and primary human pituitary adenoma cell cultures.	Oxygen	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
22225988-1	2012	INTRODUCTION: Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) correlates with poor prognosis in breast cancer patients.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-106
22225988-1	2012	INTRODUCTION: Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) correlates with poor prognosis in breast cancer patients.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
22221278-1	2012	The carbon-supported cobalt(III) complex of beta-pyrrole-brominated 5,10,15-tris(pentafluorophenyl)corrole [Co(tpfc)Br(8)/C] is introduced as a nonplatinum alternative for electrocatalytic oxygen reduction in aqueous solutions.	Oxygen	189-195	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	28-31
23080171-1	2012	Hypoxia inducible factor 1(HIF-1alpha) is the regulator of oxygen homeostasis in tissue correlated with neuroglobin (NGB) a member of the family of globins in vertebrates.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
23080146-5	2012	Accumulating evidence therefore suggests that the LKB1-AMPK signalling pathway is necessary for hypoxia-response coupling by the carotid body, and serves to regulate oxygen and therefore energy supply at the whole body level.	Oxygen	166-172	serine/threonine kinase 11	Mus musculus	50-54
22729865-1	2012	Cytochrome c oxidase (COX) catalyzes the last step in respiration, transferring electrons from cytochrome c to molecular oxygen and coupling electron transfer with proton translocation from the mitochondrial matrix to the intermembrane space.	Oxygen	121-127	cytochrome c, somatic	Homo sapiens	0-12
22729865-1	2012	Cytochrome c oxidase (COX) catalyzes the last step in respiration, transferring electrons from cytochrome c to molecular oxygen and coupling electron transfer with proton translocation from the mitochondrial matrix to the intermembrane space.	Oxygen	121-127	cytochrome c, somatic	Homo sapiens	95-107
23080146-5	2012	Accumulating evidence therefore suggests that the LKB1-AMPK signalling pathway is necessary for hypoxia-response coupling by the carotid body, and serves to regulate oxygen and therefore energy supply at the whole body level.	Oxygen	166-172	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	55-59
23080171-5	2012	The increase of NGB and HIF-1alpha expression suggests a possible role of the two oxygen sensors in the aging processes.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
22959024-2	2012	As tumors grow in situ, a fraction of it is further away from their blood supply, leading to decreased oxygen concentrations (hypoxia), which induces the hypoxia response pathways of HIF1alpha, mTOR, and UPR.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-192
22959024-2	2012	As tumors grow in situ, a fraction of it is further away from their blood supply, leading to decreased oxygen concentrations (hypoxia), which induces the hypoxia response pathways of HIF1alpha, mTOR, and UPR.	Oxygen	103-109	mechanistic target of rapamycin kinase	Homo sapiens	194-198
23080174-7	2012	Both normoxia (20%O(2)/5%CO(2)) and hypoxia (0%O(2)/5%CO(2)) induced a similar increase in the FRET emission ratio (14.5 +- 0.8 and 14.7 +- 0.8, respectively).PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole SCG with no modulation by hypoxia.	Oxygen	26-30	phosphodiesterase 3A	Homo sapiens	159-164
23080174-7	2012	Both normoxia (20%O(2)/5%CO(2)) and hypoxia (0%O(2)/5%CO(2)) induced a similar increase in the FRET emission ratio (14.5 +- 0.8 and 14.7 +- 0.8, respectively).PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole SCG with no modulation by hypoxia.	Oxygen	26-30	phosphodiesterase 4B	Homo sapiens	166-171
22056361-11	2012	The combination of hyperglycemia and high oxygen levels (21%) reduces proliferation of human first-trimester trophoblasts in a ROS-independent manner involving MAPK.	Oxygen	42-48	mitogen-activated protein kinase 3	Homo sapiens	160-164
23367297-3	2012	The catalase immobilized in chitosan matrix was coated on top of the groove to decompose residual hydrogen peroxide to oxygen.	Oxygen	119-125	catalase	Homo sapiens	4-12
22567318-4	2012	During ischemic stress, erythropoietin, which is hypoxia inducible, can contribute to brain homeostasis by increasing red blood cell production to increase the blood oxygen carrying capacity, stimulate nitric oxide production to modulate blood flow and contribute to the neurovascular response, or act directly on neural cells to provide neuroprotection as demonstrated in culture and animal models.	Oxygen	166-172	erythropoietin	Homo sapiens	24-38
22404633-3	2012	NO is synthesized from l-arginine and oxygen (O(2)) by the enzyme nitric oxide synthase (NOS).	Oxygen	38-44	nitric oxide synthase 2	Homo sapiens	66-87
22404633-3	2012	NO is synthesized from l-arginine and oxygen (O(2)) by the enzyme nitric oxide synthase (NOS).	Oxygen	46-51	nitric oxide synthase 2	Homo sapiens	66-87
22938422-10	2012	This will result in a decreased EC-SOD activity, thus leading to an increase in the steady-state concentration of O2- in this domain, and increase in EC-SOD activity in extracellular fluid.	Oxygen	114-116	superoxide dismutase 3	Homo sapiens	32-38
21546402-9	2012	Erythropoietin therapy was shown to be an independent risk factor after adjusting for all other known factors and oxygen therapy in multivariable analysis (HR 2.82, 95% CI 1.55 to 5.12).	Oxygen	114-120	erythropoietin	Homo sapiens	0-14
22538531-7	2012	The sensor contained an oxygen reservoir which was consumed by the tissue corresponding to the perfusion status of the flap.	Oxygen	24-30	arachidonate 5-lipoxygenase activating protein	Homo sapiens	119-123
22846293-2	2012	In this study, the GOX/CAT system was used to independently provide and control the amount of H2O2 and oxygen in cell culture.	Oxygen	103-109	catalase	Homo sapiens	23-26
21535910-12	2012	The proapoptotic molecules BNIP3, BNIP3L, and Beclin-1 were all highly expressed, indicating exposure of islets to oxygen and nutrient deprivation during isolation.	Oxygen	115-121	BCL2 interacting protein 3	Homo sapiens	27-32
23091723-0	2012	Oxygen versus Reactive Oxygen in the Regulation of HIF-1alpha: The Balance Tips.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
23091723-0	2012	Oxygen versus Reactive Oxygen in the Regulation of HIF-1alpha: The Balance Tips.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
23091723-6	2012	Finally, the protein CHCHD4, which modulates cellular HIF-1alpha concentrations by promoting mitochondrial electron transport chain activity, has been proposed to exert its regulatory effect by affecting cellular oxygen availability.	Oxygen	213-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
23091723-7	2012	These reports are consistent with the hypothesis that mitochondria play a critical role in the regulation of HIF-1alpha by controlling intracellular oxygen concentrations.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
22415096-8	2012	In addition, AQP1 induction in dense cultures was dependent on lowered oxygen (O(2)) tension.	Oxygen	71-77	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
22415096-8	2012	In addition, AQP1 induction in dense cultures was dependent on lowered oxygen (O(2)) tension.	Oxygen	79-84	aquaporin 1 (Colton blood group)	Homo sapiens	13-17
22415096-10	2012	CONCLUSION: These findings suggest that AQP1 could be induced by hypoxia at transcription level, and the regulation of AQP1 in PC-3M cells is dependent on calcium, PKC and p38 MAPK, as well as low oxygen tension.	Oxygen	197-203	aquaporin 1 (Colton blood group)	Homo sapiens	40-44
22415096-10	2012	CONCLUSION: These findings suggest that AQP1 could be induced by hypoxia at transcription level, and the regulation of AQP1 in PC-3M cells is dependent on calcium, PKC and p38 MAPK, as well as low oxygen tension.	Oxygen	197-203	aquaporin 1 (Colton blood group)	Homo sapiens	119-123
22538531-11	2012	CONCLUSION: Flap monitoring via oxygen imaging by means of fluorescent sensor foils appears to be a fast, non-invasive, cost-effective and thus suitable method for analyzing flap perfusion with the additional advantage of aiding decision making on flap revision.	Oxygen	32-38	arachidonate 5-lipoxygenase activating protein	Homo sapiens	12-16
22538531-11	2012	CONCLUSION: Flap monitoring via oxygen imaging by means of fluorescent sensor foils appears to be a fast, non-invasive, cost-effective and thus suitable method for analyzing flap perfusion with the additional advantage of aiding decision making on flap revision.	Oxygen	32-38	arachidonate 5-lipoxygenase activating protein	Homo sapiens	174-178
22538531-11	2012	CONCLUSION: Flap monitoring via oxygen imaging by means of fluorescent sensor foils appears to be a fast, non-invasive, cost-effective and thus suitable method for analyzing flap perfusion with the additional advantage of aiding decision making on flap revision.	Oxygen	32-38	arachidonate 5-lipoxygenase activating protein	Homo sapiens	248-252
22286561-4	2012	These studies indicate the increase of P-O-B bonds (up to Y=[B(2)O(3)]/([B(2)O(3)]+[P(2)O(5)]) 0.5 and B-O-B bonds, as well as the decrease of P-O-P bonds and non-bridging oxygens (NBOs) with rising B(2)O(3) content.	Oxygen	172-179	ER membrane protein complex subunit 3	Homo sapiens	39-44
23728971-10	2012	Inflation of the lung to an airway pressure of 40 cmH2O recruits almost all collapsed lung and the lung remains open if ventilation is with moderate oxygen concentration (&lt; 40%) but recollapses within a few minutes if ventilation is with 100% oxygen.	Oxygen	246-252	troponin T2, cardiac type	Homo sapiens	50-54
22773957-1	2012	Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost all nucleated mammalian cells.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-61
21828119-1	2012	The oxygen sensing pathway modulates erythropoietin expression.	Oxygen	4-10	erythropoietin	Homo sapiens	37-51
21828119-7	2012	Identification of the disease-causing genes will be of critical importance for a better classification of familial and acquired erythrocytosis, offering additional insight into the erythropoietin regulating oxygen sensing pathway.	Oxygen	207-213	erythropoietin	Homo sapiens	181-195
21754923-4	2012	In the oxygen-induced retinopathy (OIR) model using transgenic mice that have Tie2 promoter-driven GFP expression, we quantified Tie2GFP(+) cells in bone marrow and peripheral blood by fluorescence-activated cell sorting (FACS).	Oxygen	7-13	TEK receptor tyrosine kinase	Mus musculus	78-82
21754923-4	2012	In the oxygen-induced retinopathy (OIR) model using transgenic mice that have Tie2 promoter-driven GFP expression, we quantified Tie2GFP(+) cells in bone marrow and peripheral blood by fluorescence-activated cell sorting (FACS).	Oxygen	7-13	TEK receptor tyrosine kinase	Mus musculus	129-133
22773957-1	2012	Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost all nucleated mammalian cells.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-68
22773957-2	2012	The fundamental process adapted to cellular oxygen alteration largely depends on the refined regulation on its alpha subunit, HIF-1alpha.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
22946472-9	2012	CONCLUSION: ILP with TNF and melphalan induces severe oxygen deprivation in soft tissue sarcoma.	Oxygen	54-60	tumor necrosis factor	Homo sapiens	21-24
22462014-1	2012	Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase.	Oxygen	9-15	superoxide dismutase 1	Homo sapiens	122-142
23109831-1	2012	NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen.	Oxygen	159-165	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-32
23109831-1	2012	NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen.	Oxygen	159-165	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-38
23109849-9	2012	Interestingly, as compared to the control TE1-NT, TE1-sh-TFAM(97) exhibited lower levels of the relative mtDNA copy number (p = 0.001), mRNA of mtDNA-encoded ND1 gene (p = 0.050), succinate-supported oxygen consumption rate (p = 0.065), and ATP content (p = 0.007), but had a higher lactate concentration in the culture medium (p = 0.010) and higher protein level of lactate dehydrogenase.	Oxygen	200-206	transcription factor A, mitochondrial	Homo sapiens	57-61
22462014-1	2012	Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase.	Oxygen	9-15	superoxide dismutase 1	Homo sapiens	144-147
22530138-6	2012	Results in vitro showed that PPAL decreased oxidative deamination of GLU and oxygen consumption, whereas AAOA and OHAMINE inhibited GDH activity competitively and also inhibited oxygen consumption when alphaK reductive amination was carried out.	Oxygen	77-83	acid phosphatase, prostate	Mus musculus	29-33
22045484-0	2012	The BACE1-PSEN-AbetaPP regulatory axis has an ancient role in response to low oxygen/oxidative stress.	Oxygen	78-84	beta-secretase 1	Danio rerio	4-9
21954286-7	2012	p67(phox) is involved in the regulation of electron flow from NADPH to oxygen, leading to superoxide radical formation inside the phagosome.	Oxygen	71-77	CD33 molecule	Homo sapiens	0-3
22201682-5	2012	Consistently, Txnip-KO mitochondria were functionally and structurally altered, showing reduced oxygen consumption and ultrastructural derangements.	Oxygen	96-102	thioredoxin interacting protein	Mus musculus	14-19
22247599-6	2012	Since SOD could restrict the GSH-dependent EPR signal decay of TEMPOL, O(2) ( -) is related with this reaction.	Oxygen	71-75	superoxide dismutase 1	Homo sapiens	6-9
21989481-0	2012	Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones.	Oxygen	57-63	SUMO specific peptidase 1	Homo sapiens	25-31
22906272-0	2012	The synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines is accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels.	Oxygen	66-72	vascular endothelial growth factor A	Homo sapiens	132-166
22906272-0	2012	The synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines is accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels.	Oxygen	66-72	ATP binding cassette subfamily C member 1	Homo sapiens	171-212
22906280-1	2012	OBJECTIVE: This cross-sectional study investigated the correlation between diacron reactive oxygen metabolites (d-ROMs) and high-sensitivity C-reactive protein (hs-CRP) in subjects with or without metabolic syndrome.	Oxygen	92-98	C-reactive protein	Homo sapiens	141-159
22876780-3	2012	Mean power during the designated start section (68.5 +- 5.5 s) was 481 +- 122 W, incurring an O2 deficit of 1.58 +- 0.67 L - min(-1) highlighting a significant initial anaerobic (32.4 +- 10.2%) contribution.	Oxygen	94-96	CD59 molecule (CD59 blood group)	Homo sapiens	125-131
23960668-4	2012	Within few hours, in the afternoon of the same day after administration of ACE Inhibitor, the baby could be weaned off oxygen, maintaining on room air, oxygen saturation between 87% and 92%.	Oxygen	119-125	angiotensin I converting enzyme	Homo sapiens	75-78
22200419-9	2012	Our work also indicated a possible connection between IS and the desensitization of the oxygen-sensing mechanism in erythropoietin-producing cells, which may partly explain inadequate erythropoietin production in hypoxic kidneys of end-stage renal disease patients.	Oxygen	88-94	erythropoietin	Homo sapiens	116-130
22200419-9	2012	Our work also indicated a possible connection between IS and the desensitization of the oxygen-sensing mechanism in erythropoietin-producing cells, which may partly explain inadequate erythropoietin production in hypoxic kidneys of end-stage renal disease patients.	Oxygen	88-94	erythropoietin	Homo sapiens	184-198
23251549-4	2012	Tumor hypoxia was probed over a prolonged observation period in response to treatment with different cytotoxic agents, using a non-invasive bioluminescent ODD-Luc reporter system, in which part of the oxygen-dependent degradation (ODD) domain of HIF-1alpha is fused to luciferase.	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	246-256
22113277-2	2012	von Hippel-Lindau (VHL) tumor-suppressor protein binds and ubiquitylates the catalytic alpha subunit of HIF in an oxygen-dependent manner for rapid destruction via the 26S proteasome, thereby establishing VHL as a critical negative regulator of HIF.	Oxygen	114-120	trichoplein keratin filament binding	Homo sapiens	24-48
22222171-0	2012	Towards erythropoietin equations that estimate oxygen delivery rather than static hemoglobin targets.	Oxygen	47-53	erythropoietin	Homo sapiens	8-22
22480420-3	2012	Our results show that the inhibition of oxygen consumption rates is recovered by the addition of exogenous synthetic analog of CoQ idebenone (hydroxydecyl-ubiquinone; IDB) and cyt c.	Oxygen	40-46	cytochrome c, somatic	Homo sapiens	176-181
23236266-5	2012	Here we analyze oxygen labeling in a physiological heart phosphotransfer network with active CK and adenylate kinase (AdK) shuttles and establish which fluxes determine the labeling state.	Oxygen	16-22	adenosine kinase	Homo sapiens	118-121
23139766-0	2012	CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer"s disease.	Oxygen	44-50	sirtuin 3	Homo sapiens	4-9
23166730-1	2012	UNLABELLED: Amyloid beta-peptide (Abeta) is hypothesized to play a key role by oxidatively impairing the capacity of red blood cells (RBCs) to deliver oxygen to the brain.	Oxygen	151-157	amyloid beta precursor protein	Homo sapiens	34-39
23272129-9	2012	Moreover, rCD93D23 promoted blood vessel formation in a Matrigel-plug assay and an oxygen-induced retinopathy model in vivo.	Oxygen	83-89	BCL10, immune signaling adaptor	Rattus norvegicus	10-13
23049945-7	2012	The effect of the trypsin treatment on the transcription of VEGF peaked at 6 hours after the treatment and was comparable to the activation observed after keeping hASCs for 24 hours at 1% oxygen.	Oxygen	188-194	vascular endothelial growth factor A	Homo sapiens	60-64
23094087-3	2012	We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to oxygen/glucose deprivation, and in mice exposed to middle cerebral artery occlusion.	Oxygen	158-164	small ubiquitin-like modifier 1	Mus musculus	48-54
23094087-3	2012	We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to oxygen/glucose deprivation, and in mice exposed to middle cerebral artery occlusion.	Oxygen	158-164	small ubiquitin-like modifier 2	Mus musculus	59-65
23050013-2	2012	Activation of the hypoxia inducible factor (HIF)-1 promotes expression of genes that increase the capacity to cope with the stress imposed by a reduced oxygen environment.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
22815878-5	2012	Furthermore, cytotrophoblasts cultured under hypoxia (2% oxygen) in the presence or absence of nutlin-3 (a p53 activity stimulator) had higher levels of LC3B-II, DRAM, and M30 proteins and increased Bax mRNA expression compared with controls cultured under standard conditions.	Oxygen	57-63	DNA damage regulated autophagy modulator 1	Homo sapiens	162-166
22768306-6	2012	3) The dose-response curve demonstrated that HIF-1alpha peaked at 2.5% and NFAT5 at 1% of O(2).	Oxygen	90-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
22768306-7	2012	4) At 2.5% of O(2), the time-course curve of hypoxia demonstrated earlier induction of HIF-1alpha gene expression than NFAT5.	Oxygen	14-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
22848603-9	2012	CONCLUSION: Our results suggest that CysLT1 antagonists may have protective effects on the hypoxic heart, and improve the oxygen supply to areas of myocardial ischemia, for instance during episodes of sleep apnea.	Oxygen	122-128	cysteinyl leukotriene receptor 1	Mus musculus	37-43
22745678-9	2012	CONCLUSIONS: gammaH2AX may be involved in repair of preimplantation embryos fertilized with oxygen-stressed spermatozoa.	Oxygen	92-98	H2A.X variant histone	Mus musculus	13-22
22719883-6	2012	These cells were collected and cultured again in primate ES cell medium supplemented with bFGF in 20% O2 and maintained on PronectinF -coated dishes.	Oxygen	102-104	fibroblast growth factor 2	Homo sapiens	90-94
22701652-1	2012	Recent evidence established a crucial role for mammalian oxygen sensing transcription factor hypoxia inducible factor-1 (HIF-1) in innate immunity against intracellular pathogens.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-119
22701652-1	2012	Recent evidence established a crucial role for mammalian oxygen sensing transcription factor hypoxia inducible factor-1 (HIF-1) in innate immunity against intracellular pathogens.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-126
22764653-13	2012	They are responsible for increased oxygen delivery, i.e. by boosting angiogensis due to vascular endothelial growth factor (VEGF) release and the enhancement of red blood cell production by erythropoietin (EPO).	Oxygen	35-41	vascular endothelial growth factor A	Homo sapiens	88-122
22428001-4	2012	When primary human bronchial and human colonic epithelial cells were exposed to 10% O(2) x 1 h, ARSB activity declined by ~41% and ~30% from baseline, as nuclear hypoxia inducible factor (HIF)-1alpha increased by ~53% and ~37%.	Oxygen	84-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-199
22359545-2	2012	Possible functions of cytoglobin include buffering of intracellular oxygen and detoxification of reactive oxygen species.	Oxygen	68-74	cytoglobin	Homo sapiens	22-32
22432008-4	2012	We found that HIF-1 alpha is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-25
22108059-7	2012	Prominent among these factors are vascular endothelial growth factor and erythropoietin, which may contribute to normal angiogenesis during development, but may also cause neovascularization and vascular leakage under pathologically reduced oxygen levels.	Oxygen	241-247	vascular endothelial growth factor A	Homo sapiens	34-68
22108059-7	2012	Prominent among these factors are vascular endothelial growth factor and erythropoietin, which may contribute to normal angiogenesis during development, but may also cause neovascularization and vascular leakage under pathologically reduced oxygen levels.	Oxygen	241-247	erythropoietin	Homo sapiens	73-87
22764653-13	2012	They are responsible for increased oxygen delivery, i.e. by boosting angiogensis due to vascular endothelial growth factor (VEGF) release and the enhancement of red blood cell production by erythropoietin (EPO).	Oxygen	35-41	vascular endothelial growth factor A	Homo sapiens	124-128
22764653-13	2012	They are responsible for increased oxygen delivery, i.e. by boosting angiogensis due to vascular endothelial growth factor (VEGF) release and the enhancement of red blood cell production by erythropoietin (EPO).	Oxygen	35-41	erythropoietin	Homo sapiens	190-204
22764653-13	2012	They are responsible for increased oxygen delivery, i.e. by boosting angiogensis due to vascular endothelial growth factor (VEGF) release and the enhancement of red blood cell production by erythropoietin (EPO).	Oxygen	35-41	erythropoietin	Homo sapiens	206-209
22792045-4	2012	We examined the expression pattern of the fermentative genes PDC3, LDH1, ADH2, PFL1, and PFR1 in response to day-night cycles, continuous light, continuous darkness, and low or high oxygen availability, which are all conditions that vary on a regular basis in Chlamydomonas" natural environment.	Oxygen	182-188	uncharacterized protein	Chlamydomonas reinhardtii	61-65
22687695-7	2012	Because the alpha subunit of HIF-1 (HIF-1alpha) controls the transcriptional activity of HIF-1 and is unique in that its degradation is regulated by the oxygen partial pressure, we first developed a fusion protein probe that is degraded similarly as HIF-1alpha.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
22412226-7	2012	Prolactin and 16-kDa PRL correlated inversely with the 6-minute-walk distance (P &lt;0.01) and with peak oxygen uptake during exercise (P &lt;0.005).Serum levels of prolactin and 16-kDa PRL were significantly higher in patients with precapillary pulmonary hypertension and were inversely correlated with 6-minute-walk distance and peak oxygen uptake.These results indicate that prolactin and 16-kDa PRL might play a role in the pathophysiology of precapillary pulmonary hypertension.	Oxygen	105-111	prolactin	Homo sapiens	0-9
22412226-7	2012	Prolactin and 16-kDa PRL correlated inversely with the 6-minute-walk distance (P &lt;0.01) and with peak oxygen uptake during exercise (P &lt;0.005).Serum levels of prolactin and 16-kDa PRL were significantly higher in patients with precapillary pulmonary hypertension and were inversely correlated with 6-minute-walk distance and peak oxygen uptake.These results indicate that prolactin and 16-kDa PRL might play a role in the pathophysiology of precapillary pulmonary hypertension.	Oxygen	336-342	prolactin	Homo sapiens	165-174
22766874-4	2012	A GDE made of carbon nanoparticles bound with 30% polytetrafluoroethylene (PTFE) (wt./wt.C) to a carbon fiber paper performed best and catalyzed H(2)O(2) production from oxygen in air with a coulombic efficiency of 95.1%.	Oxygen	170-176	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	2-5
22687695-7	2012	Because the alpha subunit of HIF-1 (HIF-1alpha) controls the transcriptional activity of HIF-1 and is unique in that its degradation is regulated by the oxygen partial pressure, we first developed a fusion protein probe that is degraded similarly as HIF-1alpha.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
22687695-7	2012	Because the alpha subunit of HIF-1 (HIF-1alpha) controls the transcriptional activity of HIF-1 and is unique in that its degradation is regulated by the oxygen partial pressure, we first developed a fusion protein probe that is degraded similarly as HIF-1alpha.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
21692070-10	2011	Oxygen and bone morphogenetic protein 9 levels were shown to modulate TGF-beta-induced VEGFR2 down-regulation.	Oxygen	0-6	transforming growth factor beta 1	Homo sapiens	70-78
22138393-7	2011	Interestingly, Hamp gene expression was induced, even after subjecting rats to a 4h hypoxia treatment (8% oxygen).	Oxygen	106-112	hepcidin antimicrobial peptide	Rattus norvegicus	15-19
22215075-15	2011	This reduced oxygen availability may especially impact beta-cells whose insulin secretory function is highly dependent on oxygen.	Oxygen	13-19	insulin	Homo sapiens	72-79
22215075-15	2011	This reduced oxygen availability may especially impact beta-cells whose insulin secretory function is highly dependent on oxygen.	Oxygen	122-128	insulin	Homo sapiens	72-79
22215075-22	2011	Stabilization of HIF-1 by low oxygen conditions will drive transcription of the fluorescent protein (Figure 1).	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
21951999-3	2011	The alpha-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent manner.	Oxygen	132-138	egl-9 family hypoxia inducible factor 1	Homo sapiens	110-114
22215075-28	2011	While the low oxygen stress does not cause a pronounced drop in viability, it is clearly impacting MIN6 aggregation and function as measured by glucose-stimulated insulin secretion.	Oxygen	14-20	insulin	Homo sapiens	163-170
22215075-29	2011	Western blot analysis of encapsulated cells in 20% and 1% oxygen also showed a significant increase in HIF-1alpha for cells cultured in the low oxygen conditions which correlates with the expression of the DsRed DR protein.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
22215075-29	2011	Western blot analysis of encapsulated cells in 20% and 1% oxygen also showed a significant increase in HIF-1alpha for cells cultured in the low oxygen conditions which correlates with the expression of the DsRed DR protein.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
22134239-1	2011	The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is a master regulator of cell adaptation to decreasing oxygen levels.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-56
22134239-1	2011	The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is a master regulator of cell adaptation to decreasing oxygen levels.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
22134239-2	2011	High oxygen tension promotes proteosomal degradation of HIF-1alpha via a pathway that requires hydroxylation of prolines 402 and 564.	Oxygen	5-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
22134239-5	2011	Here we show that, in these cells, HIF-1alpha is efficiently degraded even in condition of low oxygen tension.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
22081937-6	2011	These results suggest that CL oxidation in mitochondria could occur by the reaction of molecular oxygen with the ferrous CL:cyt c complex in addition to the well-described reaction of peroxides with the ferric form.	Oxygen	97-103	cytochrome c, somatic	Homo sapiens	124-129
21816551-1	2011	Since the 1990"s, cheating athletes have abused substances to increase their oxygen transport capabilities; among these substances, recombinant EPO is the most well known.	Oxygen	77-83	erythropoietin	Homo sapiens	144-147
22070750-5	2011	The abundant oxygen-containing functional groups on the surfaces of graphene oxide nanosheets played an important role on Cd(II) and Co(II) sorption.	Oxygen	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
21964931-4	2011	Here, we show that Rg1 is an effective stimulator of HIF-1alpha under normal cellular oxygen conditions in human umbilical vein endothelial cells.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
22100406-0	2011	Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity.	Oxygen	72-78	Ndufa4, mitochondrial complex associated like 2	Mus musculus	31-39
22100406-5	2011	Our results, obtained employing NDUFA4L2-silenced cells and NDUFA4L2 knockout murine embryonic fibroblasts, indicate that hypoxia-induced NDUFA4L2 attenuates mitochondrial oxygen consumption involving inhibition of Complex I activity, which limits the intracellular ROS production under low-oxygen conditions.	Oxygen	172-178	Ndufa4, mitochondrial complex associated like 2	Mus musculus	32-40
21862725-4	2011	Consistent with this, rats administered Ang II had increased whole body heat production and oxygen consumption.	Oxygen	92-98	angiotensinogen	Rattus norvegicus	40-46
22333107-0	2011	[Effects of hyperbaric oxygen therapy in the management of chronic wounds and its correlation with CD34(+) endothelial progenitor cells].	Oxygen	23-29	CD34 molecule	Homo sapiens	99-103
21952239-5	2011	As we recently showed, VEGF is also strongly induced in endometrial cancer cells in vitro when excessive degradation of hypoxia-inducible factor 1alpha, caused by the abnormally high oxygen level to which cultured cells are exposed, is prevented.	Oxygen	183-189	vascular endothelial growth factor A	Homo sapiens	23-27
22108004-2	2011	Here we show that normobaric hyperoxia (exposure of cells to 40% oxygen for five days), and consequent activation of macroautophagy and accumulation of Abeta within lysosomes, induced apoptosis in differentiated SH-SY5Y neuroblastoma cells.	Oxygen	65-71	amyloid beta precursor protein	Homo sapiens	152-157
21774842-9	2011	There was a significant negative correlation between vascular endothelial growth factor levels and aortic O(2) saturation in the cyanotic group (p &lt; 0.05).	Oxygen	106-110	vascular endothelial growth factor A	Homo sapiens	53-87
21940948-5	2011	Second, we demonstrated that LXRalpha increased HIF-1alpha protein stability through a physical interaction between the ligand binding domain of LXRalpha and the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	162-168	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
21940948-5	2011	Second, we demonstrated that LXRalpha increased HIF-1alpha protein stability through a physical interaction between the ligand binding domain of LXRalpha and the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	162-168	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-211
21965273-7	2011	This EGCG-induced stabilization of HIF-1alpha was further shown by the stabilization of HA-tagged HIF-1alpha but not the P402A/P564A-mutated HIF-1alpha by EGCG, suggesting that EGCG targets the oxygen-dependent degradation (ODD) domain.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
21965273-7	2011	This EGCG-induced stabilization of HIF-1alpha was further shown by the stabilization of HA-tagged HIF-1alpha but not the P402A/P564A-mutated HIF-1alpha by EGCG, suggesting that EGCG targets the oxygen-dependent degradation (ODD) domain.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
21965273-7	2011	This EGCG-induced stabilization of HIF-1alpha was further shown by the stabilization of HA-tagged HIF-1alpha but not the P402A/P564A-mutated HIF-1alpha by EGCG, suggesting that EGCG targets the oxygen-dependent degradation (ODD) domain.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
21952239-5	2011	As we recently showed, VEGF is also strongly induced in endometrial cancer cells in vitro when excessive degradation of hypoxia-inducible factor 1alpha, caused by the abnormally high oxygen level to which cultured cells are exposed, is prevented.	Oxygen	183-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-151
21958548-8	2011	Recent work suggests a prominent role for O(2) substrate dependence in the short-term regulation of iNOS-mediated NO production.	Oxygen	42-46	nitric oxide synthase 2	Homo sapiens	100-104
21962636-3	2011	3T3-L1 adipocytes cultured in a 1% O2 atmosphere responded with a classic hypoxia response by elevating protein expression of HIF-1alpha.	Oxygen	35-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
22021246-9	2011	Myocardial oxygen consumption averaged 0.137 +- 0.057 mL min(-1) g(-1) in carriers and was not significantly different from controls (0.125 +- 0.043 mL min(-1) g(-1), P= 0.29).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	57-63
21925591-1	2011	Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that breaks down superoxide anion into oxygen and hydrogen peroxide in extracellular spaces and plays key roles in controlling pulmonary and vascular diseases in response to oxidative stresses.	Oxygen	108-114	superoxide dismutase 3	Homo sapiens	0-34
21925591-1	2011	Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that breaks down superoxide anion into oxygen and hydrogen peroxide in extracellular spaces and plays key roles in controlling pulmonary and vascular diseases in response to oxidative stresses.	Oxygen	108-114	superoxide dismutase 3	Homo sapiens	36-42
21958548-0	2011	Oxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase.	Oxygen	0-6	nitric oxide synthase 2	Homo sapiens	58-89
21109616-9	2011	Maximum and minimum oxygen (O(2)) saturations were significantly lower in the R-CHOP group (p=0.0444 and 0.0165, respectively).	Oxygen	20-26	DNA damage inducible transcript 3	Homo sapiens	78-84
21958548-1	2011	Inducible nitric oxide synthase (iNOS) catalyzes the reaction that converts the substrates O(2) and l-arginine to the products nitric oxide (NO) and l-citrulline.	Oxygen	91-95	nitric oxide synthase 2	Homo sapiens	0-31
21958548-1	2011	Inducible nitric oxide synthase (iNOS) catalyzes the reaction that converts the substrates O(2) and l-arginine to the products nitric oxide (NO) and l-citrulline.	Oxygen	91-95	nitric oxide synthase 2	Homo sapiens	33-37
21958548-3	2011	Physiological and pathophysiological oxygen tension can regulate NO production by iNOS at multiple levels, including transcriptional, translational, posttranslational, enzyme dimerization, cofactor availability, and substrate dependence.	Oxygen	37-43	nitric oxide synthase 2	Homo sapiens	82-86
21963991-4	2011	Using recombinant human GAPDH, we found that this glycolytic enzyme indeed catalyzes the two-electron reduction of 1,2-NQ accompanied by extensive NADH consumption under 20% oxygen conditions.	Oxygen	174-180	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	24-29
21109616-9	2011	Maximum and minimum oxygen (O(2)) saturations were significantly lower in the R-CHOP group (p=0.0444 and 0.0165, respectively).	Oxygen	28-33	DNA damage inducible transcript 3	Homo sapiens	78-84
21969601-8	2011	In summary, this study identifies hypoxia as a mediator of the miRNA-dependent gene silencing pathway through posttranslational modification of Ago2, which might be responsible for cell survival or pathological responses under low oxygen stress.	Oxygen	231-237	argonaute RISC catalytic component 2	Homo sapiens	144-148
22202117-2	2011	The HIF-1a subunit is stabilized by low oxygen, genetic alteration and cobaltous ions, and its over-expression correlates with drug resistance and increased cancer mortality in various cancer types, therefore representing an important anticancer target.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-10
22057436-4	2011	Then, O(2) (-) biosensors are fabricated by mixing superoxide dismutase (SOD) in the KMWNTs-[BMIM]PF(6) gels via monitoring oxygen produced by an enzymic reaction between SOD/O(2) (-) without the help of electron mediators.	Oxygen	124-130	superoxide dismutase 1	Homo sapiens	51-71
22057436-4	2011	Then, O(2) (-) biosensors are fabricated by mixing superoxide dismutase (SOD) in the KMWNTs-[BMIM]PF(6) gels via monitoring oxygen produced by an enzymic reaction between SOD/O(2) (-) without the help of electron mediators.	Oxygen	124-130	superoxide dismutase 1	Homo sapiens	73-76
22084410-4	2011	TDP-43 acted as a co-activator of p65, and glial cells expressing higher amounts of TDP-43 produced more proinflammatory cytokines and neurotoxic mediators after stimulation with lipopolysaccharide or reactive oxygen species.	Oxygen	210-216	TAR DNA binding protein	Mus musculus	0-6
22304097-3	2011	Considering recent evidence demonstrating that the contact angle of water on a graphitic plane is much higher than what was previously reported, we estimate the oxygen-carbon interaction for the recent SPC/Fw water model.	Oxygen	161-167	proline rich protein gene cluster	Homo sapiens	202-205
22011290-4	2011	A blue intermediate forms within 20 ms of mixing of O(2) with H200N-HPCA (H200N(Int1)(HPCA)).	Oxygen	52-56	Wnt family member 1	Homo sapiens	80-84
22011290-8	2011	Reaction of FeHPCD-HPCA with O(2) results in rapid formation of a colorless Fe(II) intermediate (FeHPCD(Int1)(HPCA)).	Oxygen	29-33	Wnt family member 1	Homo sapiens	104-108
22011290-10	2011	The absence of a chromophore from a semiquinone or evidence of a spin-coupled species in FeHPCD(Int1)(HPCA) suggests it is an intermediate occurring after O(2) activation and attack.	Oxygen	155-159	Wnt family member 1	Homo sapiens	96-100
21833390-3	2011	Compound 2 having a I4(1)/a space group exhibits a tetranuclear Co(II) cluster with a cubane topology in which the central Co(II) ion and oxygen atoms from bm occupy the alternate vertices of the cube.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21788952-2	2011	OBJECTIVES: Previous studies indicated that at least 2-h leg exercise at more than 60% maximum oxygen consumption (VO(2)max) increased plasma interleukin (IL)-6 in able-bodied (AB) subjects.	Oxygen	95-101	interleukin 6	Homo sapiens	142-160
22084410-4	2011	TDP-43 acted as a co-activator of p65, and glial cells expressing higher amounts of TDP-43 produced more proinflammatory cytokines and neurotoxic mediators after stimulation with lipopolysaccharide or reactive oxygen species.	Oxygen	210-216	TAR DNA binding protein	Mus musculus	84-90
21890695-5	2011	Here we show that Y-27632 (1 muM) increases erythrocyte deformability (5%) and increases low O(2) tension-induced ATP release (203%) from healthy human erythrocytes.	Oxygen	93-97	latexin	Homo sapiens	29-32
21915097-2	2011	HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that reduces oxygen consumption and inhibits the production of potentially harmful reactive oxygen species (ROS).	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21915097-4	2011	FoxO3A is required for hypoxic suppression of mitochondrial mass, oxygen consumption, and ROS production and promotes cell survival in hypoxia.	Oxygen	66-72	forkhead box O3	Homo sapiens	0-6
21918761-3	2011	The abundant oxygen-containing groups on the surfaces of FGO played an important role in Pb(II) ion adsorption on FGO.	Oxygen	13-19	submaxillary gland androgen regulated protein 3B	Homo sapiens	89-95
22055192-0	2011	Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha.	Oxygen	0-6	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	33-58
22055192-3	2011	Here, we show that p75 neurotrophin receptor (p75(NTR)) undergoes hypoxia-induced gamma-secretase-dependent cleavage to provide a positive feed-forward mechanism required for oxygen-dependent HIF-1alpha stabilization.	Oxygen	175-181	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	19-44
22055192-3	2011	Here, we show that p75 neurotrophin receptor (p75(NTR)) undergoes hypoxia-induced gamma-secretase-dependent cleavage to provide a positive feed-forward mechanism required for oxygen-dependent HIF-1alpha stabilization.	Oxygen	175-181	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	46-54
22055192-8	2011	Thus, hypoxia-induced intramembrane proteolysis of p75(NTR) constitutes an apical oxygen-dependent mechanism to control the magnitude of the hypoxic response.	Oxygen	82-88	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	51-59
21714485-4	2011	Laboratory work has shown that in vitro Abeta will react with Cu(2+) to induce peptide aggregation and the production of reactive oxygen species.	Oxygen	130-136	amyloid beta precursor protein	Homo sapiens	40-45
22084445-9	2011	Tumor cells ensure sufficient oxygen and nutrient supply for proliferation through lactate-induced secretion of VEGF, resulting in the formation of new vessels.	Oxygen	30-36	vascular endothelial growth factor A	Homo sapiens	112-116
21901864-5	2011	4-10% O(2) was associated with large increases in the total production of viable cells and the highest number of cells expressing Nestin, betaIII tubulin, and MAP2.	Oxygen	6-10	microtubule-associated protein 2	Mus musculus	159-163
21782234-6	2011	Oxygen and nutrient diffusion limitations through the collagen I matrix as well as competition for available nutrients resulted in growing levels of intra-cellular hypoxia, quantified by a statistically significant (p &lt; 0.01) upregulation of HIF-1alpha gene expression.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	245-255
22012496-14	2011	RESULTS: Oxygen consumption during spring-loaded-crutch ambulation (17.88 +- 2.13 mL   kg-1   min-1) was 6.2% greater (P = .015; effect size [ES] = .50) than during traditional axillary-crutch ambulation (16.84 +- 2.08 mL   kg-1   min-1).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Oxygen	106-112	catalase	Mus musculus	65-73
21394639-3	2011	We investigated if EPO production could be stimulated with a single dose of NAC, after 90 min of pure oxygen breathing.	Oxygen	102-108	erythropoietin	Homo sapiens	19-22
21704159-4	2011	We now show that SOD1 is expressed in cortical neurons, that SOD1 expression is increased by exposure of brain slice cultures to E(2), and that the E(2)-mediated increase in SOD1 expression is further augmented by exposure of brain slice cultures to increased superoxide levels or oxygen and glucose deprivation.	Oxygen	281-287	superoxide dismutase 1	Homo sapiens	17-21
21557450-2	2011	When CPF was absent, S(2)O(8)(2-) was electrochemically reduced to sulphate free radical (SO(4)( -)), and dissolved oxygen absorbed on the electrode surface was reduced to protonated superoxide anion radical (HO(2)( )).	Oxygen	116-122	nuclear receptor subfamily 5 group A member 2	Homo sapiens	5-8
21557450-8	2011	The other emitting species was excited singlet molecular oxygen pair [((1)O(2))(2)*], which originated from the chemical oxidation of CPF by SO(4)( -) and dissolved oxygen.	Oxygen	57-63	nuclear receptor subfamily 5 group A member 2	Homo sapiens	134-137
21755341-11	2011	Treatment of the MDA-MB-231 cell line with DAC followed by hypoxia (0.1% O2) resulted in down-regulation of expression of the HIF-1alpha downstream genes VEGFA and SLC2A1 (P = 0.0029).	Oxygen	73-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
21755341-11	2011	Treatment of the MDA-MB-231 cell line with DAC followed by hypoxia (0.1% O2) resulted in down-regulation of expression of the HIF-1alpha downstream genes VEGFA and SLC2A1 (P = 0.0029).	Oxygen	73-75	vascular endothelial growth factor A	Homo sapiens	154-159
22340214-14	2011	CONCLUSIONS: Combined therapy of intrapancreatic BMT and hyperbaric oxygen treatment can improve glucose control and reduce the dose of insulin and/or oral hypoglycemic drugs in type 2 DM patients, but it only improve pancreatic beta-cell function transiently.	Oxygen	68-74	insulin	Homo sapiens	136-143
21999228-0	2011	RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	120-126	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	30-40
21999228-1	2011	PURPOSE: To study RhoA activation and the effect of the Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	146-152	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	56-66
21785823-6	2011	PHD2 accumulation, which occurred concomitant with HIF1 stabilization, may have compensated for the lack of oxygen under hypoxic conditions to regulate the HIF levels.	Oxygen	108-114	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
21863063-2	2011	Recent studies showed an increase in EPO production by pharmacological activation of hypoxia-inducible transcription factors (HIFs) in dialysis patients, suggesting that desensitization of the oxygen-sensing mechanism is responsible for the development of renal anemia.	Oxygen	193-199	erythropoietin	Homo sapiens	37-40
21863063-4	2011	Here we provide evidence of an additional property that IS impairs oxygen sensing in EPO-producing cells.	Oxygen	67-73	erythropoietin	Homo sapiens	85-88
21863063-13	2011	Results of the present study provide a possible connection between a uremic toxin and the desensitization of the oxygen-sensing mechanism in EPO-producing cells, which may partly explain inadequate EPO production in hypoxic kidneys of CKD patients.	Oxygen	113-119	erythropoietin	Homo sapiens	141-144
21863063-13	2011	Results of the present study provide a possible connection between a uremic toxin and the desensitization of the oxygen-sensing mechanism in EPO-producing cells, which may partly explain inadequate EPO production in hypoxic kidneys of CKD patients.	Oxygen	113-119	erythropoietin	Homo sapiens	198-201
21557450-8	2011	The other emitting species was excited singlet molecular oxygen pair [((1)O(2))(2)*], which originated from the chemical oxidation of CPF by SO(4)( -) and dissolved oxygen.	Oxygen	165-171	nuclear receptor subfamily 5 group A member 2	Homo sapiens	134-137
22012496-14	2011	RESULTS: Oxygen consumption during spring-loaded-crutch ambulation (17.88 +- 2.13 mL   kg-1   min-1) was 6.2% greater (P = .015; effect size [ES] = .50) than during traditional axillary-crutch ambulation (16.84 +- 2.08 mL   kg-1   min-1).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	231-236
21872926-9	2011	The addition of CF to placental tissue explants in culture modulates the placental secretion of TNFalpha-receptors and TNFalpha at both physiological and atmospheric O(2) tension resulting in a concentration much higher than that found in the CF.	Oxygen	166-170	tumor necrosis factor	Homo sapiens	96-104
21887475-3	2011	Lack of oxygen (hypoxia) induces the HIF-1 (hypoxia-inducible factor-1) transcription factor, which is a heterodimer composed of a constitutively expressed beta subunit and a hypoxia-inducible alpha-subunit.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
21887475-3	2011	Lack of oxygen (hypoxia) induces the HIF-1 (hypoxia-inducible factor-1) transcription factor, which is a heterodimer composed of a constitutively expressed beta subunit and a hypoxia-inducible alpha-subunit.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-70
21887475-13	2011	Our study shows for the first time that this increase in VHL expression could be HIF-1A-dependent and serves within a negative feedback pathway during hypoxia to regulate the cell-specific oxygen threshold for HIF-1A activation.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-87
21887475-13	2011	Our study shows for the first time that this increase in VHL expression could be HIF-1A-dependent and serves within a negative feedback pathway during hypoxia to regulate the cell-specific oxygen threshold for HIF-1A activation.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	210-216
21872926-9	2011	The addition of CF to placental tissue explants in culture modulates the placental secretion of TNFalpha-receptors and TNFalpha at both physiological and atmospheric O(2) tension resulting in a concentration much higher than that found in the CF.	Oxygen	166-170	tumor necrosis factor	Homo sapiens	119-127
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-53
22102829-10	2011	FOXO is recognized as a key player in the response of size, immunity, and longevity to changes in developmental nutrition, stress, and oxygen levels.	Oxygen	135-141	forkhead box, sub-group O	Drosophila melanogaster	0-4
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-53
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-53
22021211-0	2011	Oxygen insertion catalysis by sp2 carbon.	Oxygen	0-6	Sp2 transcription factor	Homo sapiens	30-33
21909526-0	2011	Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction.	Oxygen	57-65	cytochrome c, somatic	Homo sapiens	21-33
21909526-1	2011	Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein.	Oxygen	109-113	cytochrome c, somatic	Homo sapiens	28-40
21909526-2	2011	Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.	Oxygen	0-8	cytochrome c, somatic	Homo sapiens	55-67
21909526-2	2011	Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.	Oxygen	2-8	cytochrome c, somatic	Homo sapiens	55-67
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Oxygen	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Oxygen	383-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-38
21945436-6	2011	We report that the BD lymphoblast cells contained low-levels of superoxide dismutase-1 (SOD-1) due to the long-term stress of reactive oxygen species.	Oxygen	135-141	superoxide dismutase 1	Homo sapiens	64-86
21945436-6	2011	We report that the BD lymphoblast cells contained low-levels of superoxide dismutase-1 (SOD-1) due to the long-term stress of reactive oxygen species.	Oxygen	135-141	superoxide dismutase 1	Homo sapiens	88-93
21884484-0	2011	Increasing EPO using the normobaric oxygen paradox: a "not so simple" task.	Oxygen	36-42	erythropoietin	Homo sapiens	11-14
21870836-8	2011	Only one of the two electrons that are required for the reduction of O(2) to H(2)O(2) is derived from the reduced metal site, while the Tyr(10) residue of the native Abeta peptide donates the second electron.	Oxygen	69-73	amyloid beta precursor protein	Homo sapiens	166-171
21481060-6	2011	IL-1beta and TNF-alpha, but not IFN-gamma production, was reduced by 21% O(2) .	Oxygen	73-77	interleukin 1 beta	Homo sapiens	0-8
21481060-6	2011	IL-1beta and TNF-alpha, but not IFN-gamma production, was reduced by 21% O(2) .	Oxygen	73-77	tumor necrosis factor	Homo sapiens	13-22
21481060-7	2011	Moreover, 21% O(2) levels increased the anti-inflammatory cytokines IL-10 and IL-13 while 1% O(2) tended to decrease the production of these cytokines.	Oxygen	14-18	interleukin 13	Homo sapiens	78-83
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	Wnt family member 5A	Homo sapiens	93-98
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-156
23733688-6	2011	The secretion of Epo into the circulation and hence its plasma concentrations are mainly determined by the transcription rate of the Epo gene, which itself is essentially under control of the cellular oxygen concentration.	Oxygen	201-207	erythropoietin	Homo sapiens	17-20
21993003-2	2011	The major biochemical pathway for reactive oxygen species (ROS) formation proceeds through O2- production, which is generated by NADPH oxidase, such oxidative stress can activate p38 MAPK to intensify the cytotoxic effect of CP.	Oxygen	91-93	mitogen-activated protein kinase 14	Homo sapiens	179-182
21574962-5	2011	The active GTP-bound form of RhoA was reduced in 1% oxygen, whereas activation of RhoA under hypoxic conditions rescued migration.	Oxygen	52-58	ras homolog family member A	Homo sapiens	29-33
23733688-6	2011	The secretion of Epo into the circulation and hence its plasma concentrations are mainly determined by the transcription rate of the Epo gene, which itself is essentially under control of the cellular oxygen concentration.	Oxygen	201-207	erythropoietin	Homo sapiens	133-136
23733688-7	2011	Sinks of the oxygen concentrations increase the activity of the hypoxia-inducible transcription factor (HIF), which in turn triggers Epo gene transcription.	Oxygen	13-19	erythropoietin	Homo sapiens	133-136
21722982-5	2011	MATERIALS AND METHODS: We analysed UBE2T expression by microarray, quantitative PCR and western blot analysis in a panel of cancer cell lines as a function of oxygen concentration.	Oxygen	159-165	ubiquitin conjugating enzyme E2 T	Homo sapiens	35-40
22217996-3	2011	Extracellular superoxide dismutase (SOD3), a copper and zinc superoxide dismutase, which is expressed in selected tissues, is secreted into the extracellular space and catalyzes the dismutation of superoxide radical to hydrogen peroxide and molecular oxygen.	Oxygen	251-257	superoxide dismutase 3	Homo sapiens	36-40
21881206-7	2011	Furthermore, tubular cells had reduced PGC-1alpha expression and oxygen consumption in response to TNF-alpha; however, excess PGC-1alpha reversed the latter effect.	Oxygen	65-71	tumor necrosis factor	Mus musculus	99-108
21895890-4	2011	The functional role of RAD-8 may be evolutionarily conserved because expression of the putative human homologue RTN4IP/NIMP in rad-8 rescued the increased sensitivity to oxygen in rad-8.	Oxygen	170-176	reticulon 4 interacting protein 1	Homo sapiens	119-123
21624628-1	2011	A model of sedimentary oxygen demand (SOD) for stagnant water in a lake or a reservoir is presented.	Oxygen	23-29	superoxide dismutase 1	Homo sapiens	38-41
21265612-4	2011	Culturing ASC in a hypoxic incubator (2% oxygen tension) increased the proliferation and migration, and this was mediated by Akt and ERK pathways.	Oxygen	41-47	PYD and CARD domain containing	Homo sapiens	10-13
21265612-4	2011	Culturing ASC in a hypoxic incubator (2% oxygen tension) increased the proliferation and migration, and this was mediated by Akt and ERK pathways.	Oxygen	41-47	AKT serine/threonine kinase 1	Homo sapiens	125-128
21624628-4	2011	SOD is found to be substantially limited by oxygen transfer in the water column when water is stagnant.	Oxygen	44-50	superoxide dismutase 1	Homo sapiens	0-3
21624628-5	2011	When flow over the sediment surface is present, SOD becomes larger than that for stagnant water, depending on flow velocity and the biochemical oxygen uptake rate in the sediment.	Oxygen	144-150	superoxide dismutase 1	Homo sapiens	48-51
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Oxygen	109-115	superoxide dismutase 1	Homo sapiens	23-26
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Oxygen	109-115	superoxide dismutase 1	Homo sapiens	47-50
21624628-7	2011	The difference between SOD with fluid flow and SOD for stagnant water becomes significant as the biochemical oxygen uptake rate becomes larger, i.e. SOD is 10-100 times larger when flow over the sediment surface is present.	Oxygen	109-115	superoxide dismutase 1	Homo sapiens	47-50
21854046-4	2011	We explain why the oxygen vacancy in CdO acts as a shallow donor and does not display negative-U behavior similar to all other wide band gap n-type oxides.	Oxygen	19-25	cell adhesion associated, oncogene regulated	Homo sapiens	37-40
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Oxygen	17-21	ryanodine receptor 1	Homo sapiens	141-145
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Oxygen	53-57	ryanodine receptor 1	Homo sapiens	141-145
21896730-5	2011	These findings reveal a molecular mechanism for O(2)-based signaling by an NADPH oxidase and demonstrate a physiological role for oxidative modification of RyR1.	Oxygen	48-52	ryanodine receptor 1	Homo sapiens	156-160
21757736-2	2011	A controlled in vitro oxygen consumption assay was carried out to analyze the ERO1-PDI reaction.	Oxygen	22-28	ER oxidoreductin	Saccharomyces cerevisiae S288C	78-82
21911814-9	2011	Total systemic oxygen delivery was markedly reduced in the hybrid palliation (Blalock-Tausig shunt 591, right ventricle-to-pulmonary artery shunt 640, and hybrid 475 mL   min(-1)   m(-2)).	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	171-177
21677261-6	2011	Thus MCM proteins inhibit HIF activity via two distinct O(2)-dependent mechanisms.	Oxygen	56-60	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	5-8
21601556-2	2011	Care is needed to stabilize HIF-1alpha protein during sample preparation for Western blot analysis due to its rapid degradation in the presence of oxygen.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
21850721-8	2011	The highest oxygen permeation rate achieved a value of 2.02 cc min(-1) cm(-2) at 1273 K for Sr(3)Ti(0.8)Co(1.2)O(7-delta).	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	63-69
21776535-6	2011	The first complexed Pb(II) ion acts as a template to bring the host into a cone conformation and induces a positive allosteric effect for the extraction of the second Pb(II) ion at an oxygen rich coordinating site composed of carboxyl groups.	Oxygen	184-190	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
21776535-6	2011	The first complexed Pb(II) ion acts as a template to bring the host into a cone conformation and induces a positive allosteric effect for the extraction of the second Pb(II) ion at an oxygen rich coordinating site composed of carboxyl groups.	Oxygen	184-190	submaxillary gland androgen regulated protein 3B	Homo sapiens	167-173
21815644-1	2011	4-Hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate synthase (HMS) each catalyze similar complex dioxygenation reactions using the substrates 4-hydroxyphenylpyruvate (HPP) and dioxygen.	Oxygen	24-32	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	37-41
21685248-3	2011	The underlying signaling events leading to the accumulation of HIF1A in the presence of oxygen are still poorly understood.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-68
21633368-0	2011	HIF-1alpha in epidermis: oxygen sensing, cutaneous angiogenesis, cancer, and non-cancer disorders.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21723853-6	2011	Hyperoxia (100% O(2)) attenuated both NO donor-induced accumulation of HIF-1alpha and inhibition of HPH-mediated hydroxylation.	Oxygen	16-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
21723853-9	2011	Our data suggest that NO inhibits HPH-2 via competing with dioxygen and that the discriminative effect of NO on CPHs and HPH-2 is attributable to the difference in the affinity of the two enzymes toward dioxygen.	Oxygen	203-211	egl-9 family hypoxia inducible factor 1	Homo sapiens	34-39
21723853-9	2011	Our data suggest that NO inhibits HPH-2 via competing with dioxygen and that the discriminative effect of NO on CPHs and HPH-2 is attributable to the difference in the affinity of the two enzymes toward dioxygen.	Oxygen	203-211	egl-9 family hypoxia inducible factor 1	Homo sapiens	121-126
21633368-2	2011	Skin epidermal oxygenation occurs mostly through atmospheric oxygen rather than tissue vasculature, resulting in a mildly hypoxic microenvironment that favors increased expression of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-214
21055994-5	2011	The results of the current study, as a proof of concept, have shown that the device can generate oxygen at a rate of 4.06 muM O(2)/(cm(2)min), thus extending its possible application range to the full oxygenation of flowing venous blood.	Oxygen	97-103	latexin	Homo sapiens	122-125
21633368-2	2011	Skin epidermal oxygenation occurs mostly through atmospheric oxygen rather than tissue vasculature, resulting in a mildly hypoxic microenvironment that favors increased expression of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-226
22024847-10	2011	CONCLUSIONS: Sinonasal epithelial CFTR and TMEM16A-mediated Cl(-)  transport and mRNA expression were robustly decreased in an oxygen-restricted environment.	Oxygen	127-133	CF transmembrane conductance regulator	Homo sapiens	34-38
22024847-2	2011	The objectives of the present study were to investigate the role of oxygen restriction in 1) Cl(-)  transport across primary sinonasal epithelial monolayers, 2) expression of the apical Cl(-)  channels cystic fibrosis transmembrane conductance regulator (CFTR) and transmembrane protein 16A (TMEM16A), and 3) the pathogenesis of chronic rhinosinusitis.	Oxygen	68-74	CF transmembrane conductance regulator	Homo sapiens	202-253
21757507-0	2011	Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.	Oxygen	52-58	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	93-98
21615413-8	2011	ERF73/HRE1-ox1 and ERF73/HRE1-ox5 plants that were exposed to 5% O2 did not show enhanced ADH activity after treatment with ethylene, indicating that the ethylene response with respect to ADH activity was saturated in the ERF73/HRE1ox lines.	Oxygen	65-67	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-5
21615413-8	2011	ERF73/HRE1-ox1 and ERF73/HRE1-ox5 plants that were exposed to 5% O2 did not show enhanced ADH activity after treatment with ethylene, indicating that the ethylene response with respect to ADH activity was saturated in the ERF73/HRE1ox lines.	Oxygen	65-67	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	19-24
21615413-8	2011	ERF73/HRE1-ox1 and ERF73/HRE1-ox5 plants that were exposed to 5% O2 did not show enhanced ADH activity after treatment with ethylene, indicating that the ethylene response with respect to ADH activity was saturated in the ERF73/HRE1ox lines.	Oxygen	65-67	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	19-24
21615413-10	2011	Our data show that ethylene regulates metabolic adaptation to low oxygen stress in the Arabidopsis root through ERF73/ HRE1.	Oxygen	66-72	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	112-117
21615413-10	2011	Our data show that ethylene regulates metabolic adaptation to low oxygen stress in the Arabidopsis root through ERF73/ HRE1.	Oxygen	66-72	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	119-123
21775632-2	2011	They use the hypoxia-sensitive stabilization of the hypoxia-inducible factor-1alpha (HIF-1alpha) transcription factor to engage specific transcriptional programs in response to oxygen changes.	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-83
21775632-2	2011	They use the hypoxia-sensitive stabilization of the hypoxia-inducible factor-1alpha (HIF-1alpha) transcription factor to engage specific transcriptional programs in response to oxygen changes.	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
21698390-7	2011	Adiponectin gene expression was reduced at 15% O2 and below, while adiponectin release was significantly reduced at 5% O2.	Oxygen	47-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
21698390-7	2011	Adiponectin gene expression was reduced at 15% O2 and below, while adiponectin release was significantly reduced at 5% O2.	Oxygen	119-121	adiponectin, C1Q and collagen domain containing	Homo sapiens	67-78
21698390-9	2011	The alterations in substrate transport were accompanied by parallel changes in transporter gene expression, GLUT1 and MCT1 mRNA level increasing from 15% and 10% O2, respectively.	Oxygen	162-164	solute carrier family 16 member 1	Homo sapiens	118-122
21844787-1	2011	Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors hypoxia-inducible factor 1alpha and nuclear factor kappaB (NF-kappaB) via inhibition of oxygen sensing hydroxylase enzymes.	Oxygen	216-222	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	187-196
22276431-6	2011	The conclusion is made, that the increase of O2(.-) generation in wheat coleoptiles under the action of SaA and SuA is related, probably, to the increase of apoplast peroxidase and NADP.H-oxidase activity, and the rise of H2O2 content is related to the growth of SOD activity.	Oxygen	45-47	respiratory burst oxidase homolog protein A	Triticum aestivum	181-195
21690092-3	2011	Formation of the dioxygen adduct and oxidation of Trp were accelerated by the addition of small amounts of hydrogen peroxide, and both processes were inhibited in the presence of either superoxide dismutase or catalase.	Oxygen	17-25	catalase	Homo sapiens	210-218
21809858-2	2011	Oxygen evolution activity, which is inhibited in the presence of the herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), is recovered by adding Co(III) complexes.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	150-157
22176958-6	2011	Multiple linear regression analysis showed that fasting plasma insulin and insulin resistance was positive correlation with apnea-hypopnea index, while they also negatively associated with saturation of minimum oxygen.	Oxygen	211-217	insulin	Homo sapiens	63-70
22176958-6	2011	Multiple linear regression analysis showed that fasting plasma insulin and insulin resistance was positive correlation with apnea-hypopnea index, while they also negatively associated with saturation of minimum oxygen.	Oxygen	211-217	insulin	Homo sapiens	75-82
22176958-7	2011	CONCLUSIONS: FIns and insulin resistance strongly associate with AHI and levels of saturation of minimum oxygen from skin.	Oxygen	105-111	insulin	Homo sapiens	22-29
21681331-1	2011	The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant.	Oxygen	183-189	deoxyhypusine synthase	Homo sapiens	161-165
21849555-0	2011	Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors.	Oxygen	0-6	glutamate metabotropic receptor 1	Rattus norvegicus	113-119
21849555-2	2011	It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia, oxygen/glucose deprivation (OGD), leads to an enhanced permeability of AMPARs to Ca(2+), resulting in delayed cell death.	Oxygen	117-123	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	188-194
21683784-5	2011	Abeta(25-35)-induced neuronal toxicity was inhibited by the overexpression of CypB as measured by cell viability, apoptotic morphology, sub-G1 cell population, intracellular reactive oxygen species accumulation, activated caspase-3, PARP cleavage, Bcl-2 proteins, mitogen-activated protein kinase (MAPK) activation, and phosphoinositide 3-kinase (PI-3-K) activation.	Oxygen	183-189	cytochrome P450, family 4, subfamily a, polypeptide 28, pseudogene	Mus musculus	78-82
21710591-1	2011	Erythropoietin (EPO) and other erythropoiesis-stimulating agents possess a high misuse potential in elite sport due to their ability to increase the oxygen transport capacity, which plays a vital role in enhancing endurance performance.	Oxygen	149-155	erythropoietin	Homo sapiens	0-14
21710591-1	2011	Erythropoietin (EPO) and other erythropoiesis-stimulating agents possess a high misuse potential in elite sport due to their ability to increase the oxygen transport capacity, which plays a vital role in enhancing endurance performance.	Oxygen	149-155	erythropoietin	Homo sapiens	16-19
21795816-0	2011	Distinguishing between Cl- and O2(2-) as the bridging element between Fe3+ and Cu2+ in resting-oxidized cytochrome c oxidase.	Oxygen	31-33	cytochrome c, somatic	Homo sapiens	104-116
21659512-8	2011	Notably, USP13 expression is attenuated in melanoma cells maintained under hypoxia, thereby relieving Siah2 inhibition and increasing its activity under low oxygen levels.	Oxygen	157-163	ubiquitin specific peptidase 13	Homo sapiens	9-14
21609781-7	2011	Percentage of cells showing ATR foci were more with gamma however number of foci per cell were more in case of oxygen beam.	Oxygen	111-117	ATR serine/threonine kinase	Homo sapiens	28-31
21609781-8	2011	Oxygen beam irradiated cells showed phosphorylation of Chk1, Chk2 and p53.	Oxygen	0-6	checkpoint kinase 1	Homo sapiens	55-59
21609781-8	2011	Oxygen beam irradiated cells showed phosphorylation of Chk1, Chk2 and p53.	Oxygen	0-6	tumor protein p53	Homo sapiens	70-73
21609781-10	2011	The noteworthy finding of this study is the activation of the sensor proteins, ATM and ATR by oxygen irradiation and the significant activation of Chk1, Chk2 and p53 only in the oxygen beam irradiated cells.	Oxygen	94-100	ATR serine/threonine kinase	Homo sapiens	87-90
21609781-10	2011	The noteworthy finding of this study is the activation of the sensor proteins, ATM and ATR by oxygen irradiation and the significant activation of Chk1, Chk2 and p53 only in the oxygen beam irradiated cells.	Oxygen	178-184	checkpoint kinase 1	Homo sapiens	147-151
21609781-10	2011	The noteworthy finding of this study is the activation of the sensor proteins, ATM and ATR by oxygen irradiation and the significant activation of Chk1, Chk2 and p53 only in the oxygen beam irradiated cells.	Oxygen	178-184	tumor protein p53	Homo sapiens	162-165
21561530-3	2011	Among these pathways, evidence has directly pointed to the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway, whose activation resulted in tolerance to the absence of nutrients and oxygen when tumor angiogenesis has been inhibited.	Oxygen	184-190	thymoma viral proto-oncogene 1	Mus musculus	89-92
21338656-1	2011	The hypoxia inducible factor-1alpha (HIF-1alpha) is a pleiotropic transcription factor typically activated in response to low oxygen tension as well as other stress factors in normoxic conditions.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
21338656-1	2011	The hypoxia inducible factor-1alpha (HIF-1alpha) is a pleiotropic transcription factor typically activated in response to low oxygen tension as well as other stress factors in normoxic conditions.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
21069338-3	2011	SSAT1 has been reported to bind to HIF-1alpha and RACK1, resulting in oxygen-independent HIF-1 ubiquitination and degradation.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
21069338-4	2011	SSAT2, a related protein, stabilizes the interaction of the VHL protein and elongin C with HIF-1 leading to oxygen-dependent HIF-1alpha ubiquitination and degradation.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
21561530-5	2011	In modeled microenvironments in vitro, we observed that the phosphorylation of Akt in tumor cells was increased gradually in the absence of serum and oxygen in a time-dependent manner.	Oxygen	150-156	thymoma viral proto-oncogene 1	Mus musculus	79-82
21701263-4	2011	Here, we demonstrate that siRNA oligonucleotides targeting the mRNA surveillance proteins SMG1, Upf1, Upf2, or the PIKK protein ATM attenuated p53 (ser15) phosphorylation in cells damaged by high oxygen (hyperoxia), a model of persistent oxidative stress that damages nucleotides.	Oxygen	196-202	tumor protein p53	Homo sapiens	143-146
21573718-5	2011	We found a decrease in the growth of fibroblasts and in the expression of ILGF-1 and TGF-beta messengers in keloid and nonkeloid fibroblast after chronic exposition to hyperbaric oxygenation compared with normal oxygen partial pressure.	Oxygen	179-185	transforming growth factor beta 1	Homo sapiens	85-93
21791526-1	2011	The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors.	Oxygen	168-174	mechanistic target of rapamycin kinase	Homo sapiens	4-33
21791526-1	2011	The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors.	Oxygen	168-174	mechanistic target of rapamycin kinase	Homo sapiens	35-39
21659868-3	2011	RECENT FINDINGS: As a well known example, physical exercise at high altitude results in the transcriptional induction of erythropoietin that functions to increase oxygen carrying capacity and red cell volume.	Oxygen	163-169	erythropoietin	Homo sapiens	121-135
21614571-4	2011	HIF-1 is a critical transcription factor involved in oxygen homeostasis that regulates a variety of adaptive responses to hypoxia, including angiogenesis, metabolic reprogramming and survival.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21614571-5	2011	Thus, destabilisation of HIF-1 is likely to have a negative impact on cell and tissue adaptation to low oxygen.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-30
21614571-6	2011	Indeed, destabilisation of HIF-1 by high glucose levels has serious consequences in various organs and tissues, including myocardial collateralisation, wound healing, renal, neural and retinal function, as a result of poor cell and tissue responses to low oxygen.	Oxygen	256-262	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-32
21576503-3	2011	Here, we show in humans that mass-related BMR correlates strongly to the mitochondrial oxygen affinity (p50(mito); R(2)=0.66, P=0.0004) measured in isolated skeletal muscle mitochondria.	Oxygen	87-93	nuclear factor kappa B subunit 1	Homo sapiens	104-107
21677035-6	2011	Treatment of an endometrial epithelial cell line and primary human endometrial stromal cells with 100 nm PGF2alpha or hypoxia (0.5% O2) resulted in significant increases in VEGF mRNA and protein.	Oxygen	132-134	vascular endothelial growth factor A	Homo sapiens	173-177
21766199-1	2011	The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also share a number of uncanny molecular and mechanistic similarities.	Oxygen	19-25	cytochrome c, somatic	Homo sapiens	76-88
21766199-1	2011	The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also share a number of uncanny molecular and mechanistic similarities.	Oxygen	172-180	cytochrome c, somatic	Homo sapiens	76-88
21766199-1	2011	The photosynthetic oxygen evolving complex (PSII-OEC) and the mitochondrial cytochrome c oxidase (CcO) not only catalyze anti-parallel reactions (the OEC oxidizes water to dioxygen, whereas CcO reduces dioxygen to water), they also share a number of uncanny molecular and mechanistic similarities.	Oxygen	202-210	cytochrome c, somatic	Homo sapiens	76-88
22020111-7	2011	The evolutionary self-association of these many genes under the common control of Nrf2 suggests that the immune and inflammatory systems may present the largest demand for increased antioxidant protection, apart from constitutive oxidative stress resulting from mitochondrial oxygen consumption for metabolic purposes.	Oxygen	276-282	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
21397696-5	2011	We tested the hypothesis about whether UCP4 contributes to the regulation of oxidative stress using the model of oxygen deprivation.	Oxygen	113-119	solute carrier family 25, member 27	Rattus norvegicus	39-43
21486751-1	2011	The transcription factor HIF-1alpha (hypoxia inducible factor 1alpha) has an essential role in the maintenance of oxygen homeostasis in metazoans.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
21486751-1	2011	The transcription factor HIF-1alpha (hypoxia inducible factor 1alpha) has an essential role in the maintenance of oxygen homeostasis in metazoans.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-68
21611730-5	2011	The peak oxygen uptake was 26% higher in the trained than in the untrained muscle (395 vs. 315 ml min(-1) kg(-1), respectively; P&lt;0.01).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	98-104
21622558-0	2011	Oxygen supply from the bird"s eye perspective: globin E is a respiratory protein in the chicken retina.	Oxygen	0-6	eye-globin	Gallus gallus	47-55
21611730-7	2011	The difference between the trained and untrained muscles with respect to peak oxygen uptake (80 ml min(-1) kg(-1)) corresponded to a flux through the Krebs cycle of 1.05 mumol min(-1) g(-1), and the corresponding difference in oxoglutarate dehydrogenase activity (at 38 C) was 0.83 mumol min(-1) g(-1).	Oxygen	78-84	CD59 molecule (CD59 blood group)	Homo sapiens	99-105
21611730-7	2011	The difference between the trained and untrained muscles with respect to peak oxygen uptake (80 ml min(-1) kg(-1)) corresponded to a flux through the Krebs cycle of 1.05 mumol min(-1) g(-1), and the corresponding difference in oxoglutarate dehydrogenase activity (at 38 C) was 0.83 mumol min(-1) g(-1).	Oxygen	78-84	CD59 molecule (CD59 blood group)	Homo sapiens	176-182
21611730-7	2011	The difference between the trained and untrained muscles with respect to peak oxygen uptake (80 ml min(-1) kg(-1)) corresponded to a flux through the Krebs cycle of 1.05 mumol min(-1) g(-1), and the corresponding difference in oxoglutarate dehydrogenase activity (at 38 C) was 0.83 mumol min(-1) g(-1).	Oxygen	78-84	CD59 molecule (CD59 blood group)	Homo sapiens	176-182
21503666-4	2011	When inhaled O(2) was enriched with oxygen cation, O (2) ( +) , the Mn-SOD expression and activity were stimulated to similar extend, but lipid peroxidation and protein oxidation were prevented.	Oxygen	13-17	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	68-74
21503666-4	2011	When inhaled O(2) was enriched with oxygen cation, O (2) ( +) , the Mn-SOD expression and activity were stimulated to similar extend, but lipid peroxidation and protein oxidation were prevented.	Oxygen	36-42	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	68-74
21503666-4	2011	When inhaled O(2) was enriched with oxygen cation, O (2) ( +) , the Mn-SOD expression and activity were stimulated to similar extend, but lipid peroxidation and protein oxidation were prevented.	Oxygen	51-56	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	68-74
21622558-9	2011	Spectroscopic analysis and ligand binding kinetics of recombinant chicken GbE reveal a penta-coordinated globin with an oxygen affinity of P(50) = 5.8 torrs at 25  C and 15 torrs at 41  C. Together these data suggest that GbE helps to sustain oxygen supply to the avian retina.	Oxygen	120-126	eye-globin	Gallus gallus	74-77
21622558-9	2011	Spectroscopic analysis and ligand binding kinetics of recombinant chicken GbE reveal a penta-coordinated globin with an oxygen affinity of P(50) = 5.8 torrs at 25  C and 15 torrs at 41  C. Together these data suggest that GbE helps to sustain oxygen supply to the avian retina.	Oxygen	243-249	eye-globin	Gallus gallus	74-77
21672517-0	2011	Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK.	Oxygen	60-66	natriuretic peptide A	Homo sapiens	0-26
21665470-1	2011	Oxygen dependent degradation of hypoxia-inducible factor (HIF)-1alpha is triggered with hydroxylation by proline hydroxylase domain 2 (PHD2) under normoxic conditions.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-69
21665470-1	2011	Oxygen dependent degradation of hypoxia-inducible factor (HIF)-1alpha is triggered with hydroxylation by proline hydroxylase domain 2 (PHD2) under normoxic conditions.	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	105-133
21665470-1	2011	Oxygen dependent degradation of hypoxia-inducible factor (HIF)-1alpha is triggered with hydroxylation by proline hydroxylase domain 2 (PHD2) under normoxic conditions.	Oxygen	0-6	egl-9 family hypoxia inducible factor 1	Homo sapiens	135-139
21775280-3	2011	Although HIF-alpha is a key regulator of the low-oxygen stress response, here it acts without its HIF-beta partner by interacting with and stabilizing the Notch receptor.	Oxygen	49-55	similar	Drosophila melanogaster	9-18
21775280-4	2011	These roles for HIF-alpha and Notch are atypical in multiple ways, from the activity of HIF-alpha under normal oxygen tensions and without its partner HIF-beta to the ligand-independent activity of Notch, and serve as a challenge to identify other noncanonical uses of well-studied signaling pathways.	Oxygen	111-117	similar	Drosophila melanogaster	16-25
21775280-4	2011	These roles for HIF-alpha and Notch are atypical in multiple ways, from the activity of HIF-alpha under normal oxygen tensions and without its partner HIF-beta to the ligand-independent activity of Notch, and serve as a challenge to identify other noncanonical uses of well-studied signaling pathways.	Oxygen	111-117	similar	Drosophila melanogaster	88-97
21672517-4	2011	Here we demonstrate that ANP regulates lipid metabolism and oxygen utilization in differentiated human adipocytes by activating the alpha2 subunit of AMPK.	Oxygen	60-66	natriuretic peptide A	Homo sapiens	25-28
21672517-5	2011	ANP treatment increased lipolysis by seven fold and oxygen consumption by two fold, both of which were attenuated by inhibition of AMPK activity.	Oxygen	52-58	natriuretic peptide A	Homo sapiens	0-3
21672517-7	2011	ANP-induced activation of AMPK enhanced mitochondrial oxidative capacity as evidenced by a two fold increase in oxygen consumption and induction of mitochondrial genes, including carnitine palmitoyltransferase 1A (CPT1a) by 1.4-fold, cytochrome C (CytC) by 1.3-fold, and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) by 1.4-fold.	Oxygen	112-118	natriuretic peptide A	Homo sapiens	0-3
21670228-0	2011	Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation.	Oxygen	25-31	insulin	Homo sapiens	90-97
21641423-4	2011	Under the optimal conditions for luminol-O(2) system, the ECL signal intensity of luminol was linear with the concentration of dissolved oxygen in the range between 0.08 and 0.94 mM (r=0.9996) and for luminol-H(2)O(2) system, the ECL signal intensity of luminol was linear with the concentration of glucose in the range between 0.1 and 1000 muM (r=0.9998).	Oxygen	137-143	latexin	Homo sapiens	341-344
21670228-3	2011	We hypothesized that adipose tissue blood flow (ATBF) regulates AT oxygen partial pressure (AT P(O2)), thereby affecting AT inflammation and insulin sensitivity.	Oxygen	67-73	insulin	Homo sapiens	141-148
21670228-3	2011	We hypothesized that adipose tissue blood flow (ATBF) regulates AT oxygen partial pressure (AT P(O2)), thereby affecting AT inflammation and insulin sensitivity.	Oxygen	97-99	insulin	Homo sapiens	141-148
21670228-6	2011	Local administration of angiotensin II (vasoconstrictor) in abdominal subcutaneous AT decreased ATBF and AT P(O2), whereas infusion of isoprenaline (vasodilator) evoked opposite effects.	Oxygen	110-112	angiotensinogen	Homo sapiens	24-38
21536847-7	2011	POTS subjects had an increased peripheral chemoreflex sensitivity (in l min(-1) %oxygen(-1)) in response to hypoxia (0.42 +- 0.38 vs. 0.19 +- 0.17) but a decreased central chemoreflex sensitivity (l min(-1) Torr(-1)) CO(2) response (0.49 +- 0.38 vs. 1.04 +- 0.18) compared with controls.	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	72-78
20731624-8	2011	DM2 erythrocytes and erythrocytes incubated with insulin at levels similar to those seen in pre-diabetes fail to release ATP in response to reduced O(2) tension.	Oxygen	148-152	insulin	Homo sapiens	49-56
21515660-8	2011	Overnight (24 h) exposure of ASM cells to 50% oxygen increased BDNF and TrkB expression and potentiated both SP- and BDNF-induced enhancement of [Ca(2+)](i) (P &lt; 0.05).	Oxygen	46-52	tachykinin precursor 1	Homo sapiens	109-111
21763979-4	2011	Oxygen-dependent factors leading to microvascular degeneration include generation of reactive oxygen species and suppression of specific oxygen-regulated vascular survival factors, such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	189-223
21763979-4	2011	Oxygen-dependent factors leading to microvascular degeneration include generation of reactive oxygen species and suppression of specific oxygen-regulated vascular survival factors, such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	225-229
21763979-4	2011	Oxygen-dependent factors leading to microvascular degeneration include generation of reactive oxygen species and suppression of specific oxygen-regulated vascular survival factors, such as vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	0-6	erythropoietin	Homo sapiens	235-249
21718164-5	2011	Similarly, functional mutations in the hypoxia-inducible transcription factor 1alpha (HIF-1alpha) gene that represents the oxygen-dependent subunit of the HIF-1 heterodimer, the latter being the main regulator of over 100 hypoxia-inducible genes, have not been described so far.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
20732359-1	2011	Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to reduced oxygen availability by regulating gene expression.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20732359-1	2011	Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to reduced oxygen availability by regulating gene expression.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21674817-13	2011	Then, it was used to study c-kit expression of CD34+ cells at 5% O2, using 21%-O2 cultures as a control.	Oxygen	65-67	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-32
21674817-13	2011	Then, it was used to study c-kit expression of CD34+ cells at 5% O2, using 21%-O2 cultures as a control.	Oxygen	65-67	CD34 molecule	Homo sapiens	47-51
21873755-8	2011	PSG findings were abnormal in 19/24 patients (79.2%) with a nadir of oxygen saturation (pulse oximetry) below 90% and/or a nadir of transcutaneous partial pressure of oxygen below 45 mmHg.	Oxygen	69-75	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
21873755-8	2011	PSG findings were abnormal in 19/24 patients (79.2%) with a nadir of oxygen saturation (pulse oximetry) below 90% and/or a nadir of transcutaneous partial pressure of oxygen below 45 mmHg.	Oxygen	167-173	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
21337334-7	2011	Despite an increase in survival rate, bcl-2 over-expression resulted in a decrease of specific productivity, glucose consumption, oxygen uptake rate and intracellular protein content, indicating a lower energy generating metabolism.	Oxygen	130-136	B cell leukemia/lymphoma 2	Mus musculus	38-43
21555366-0	2011	Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.	Oxygen	100-106	AKT serine/threonine kinase 1	Homo sapiens	0-3
21555366-4	2011	By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms.	Oxygen	28-34	AKT serine/threonine kinase 1	Homo sapiens	48-51
21617369-3	2011	TET, Jumonji-family histone demethylases, and prolyl hydroxylase, a repressor of HIF1alpha under high oxygen conditions, all require alpha ketoglutarate (alpha-KG) as cofactors for their activation.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-90
21419845-7	2011	The suppression of oxygen consumption by addition of SOD or catalase further confirmed the production of superoxide and hydrogen peroxide.	Oxygen	19-25	superoxide dismutase 1	Homo sapiens	53-56
21419845-7	2011	The suppression of oxygen consumption by addition of SOD or catalase further confirmed the production of superoxide and hydrogen peroxide.	Oxygen	19-25	catalase	Homo sapiens	60-68
21800501-6	2011	The decreased activity of superoxide dismutase (SOD) and an increased activity of catalase as well as an increased activity of xanthine oxidase (XO) indicate generation and possible accumulation of reactive oxygen intermediates.	Oxygen	207-213	catalase	Rattus norvegicus	82-90
21718164-5	2011	Similarly, functional mutations in the hypoxia-inducible transcription factor 1alpha (HIF-1alpha) gene that represents the oxygen-dependent subunit of the HIF-1 heterodimer, the latter being the main regulator of over 100 hypoxia-inducible genes, have not been described so far.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-91
21978706-1	2011	The present study aims to assess the protective role of the antioxidant enzyme catalase (CAT) with relation to hydrogen peroxide (H(2)O(2)) degradation in oxygen plus water on electrophysiological and fluorescence changes induced by in vitro ischemia and on brain damage produced by transient in vivo ischemia.	Oxygen	155-161	catalase	Mus musculus	79-87
21978706-1	2011	The present study aims to assess the protective role of the antioxidant enzyme catalase (CAT) with relation to hydrogen peroxide (H(2)O(2)) degradation in oxygen plus water on electrophysiological and fluorescence changes induced by in vitro ischemia and on brain damage produced by transient in vivo ischemia.	Oxygen	155-161	catalase	Mus musculus	89-92
21742796-15	2011	More recently, genetic and pharmacological approaches have begun to unravel some other key regulators of vascular normalization such as proteins that regulate tissue oxygen sensing (PHD2) and vessel maturation (PDGFRbeta, RGS5, Ang1/2, TGF-beta).	Oxygen	166-172	egl-9 family hypoxia inducible factor 1	Homo sapiens	182-186
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-164
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	216-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	216-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-164
21555452-1	2011	Oxygen-dependent regulation of the transcription factor HIF-1alpha relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1alpha (HIF-1alpha) protein at two prolines during normal oxygen conditions, resulting in degradation by the proteasome.	Oxygen	216-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
21646714-9	2011	The global O(2) uptake measured by EIT was 208 +- 79 ml min(-1) corresponding to the values obtained by metabolic gas exchange (259 +- 73 ml min(-1); Spearman correlation coefficient: 0.81, p = 0.02).	Oxygen	11-15	CD59 molecule (CD59 blood group)	Homo sapiens	56-62
21646714-9	2011	The global O(2) uptake measured by EIT was 208 +- 79 ml min(-1) corresponding to the values obtained by metabolic gas exchange (259 +- 73 ml min(-1); Spearman correlation coefficient: 0.81, p = 0.02).	Oxygen	11-15	CD59 molecule (CD59 blood group)	Homo sapiens	141-147
21353244-6	2011	RESULTS: Predictors of ESBP were cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) (rs28360521) CC genotype (OR, 2.92; 95% CI, 1.48-5.79), adjusted for outpatient oxygen therapy (OR, 4.53; 95% CI, 2.23-8.81) and history of urinary tract infection (OR, 4.68; 95% CI, 1.47-14.86).	Oxygen	176-182	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	33-86
21353244-6	2011	RESULTS: Predictors of ESBP were cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) (rs28360521) CC genotype (OR, 2.92; 95% CI, 1.48-5.79), adjusted for outpatient oxygen therapy (OR, 4.53; 95% CI, 2.23-8.81) and history of urinary tract infection (OR, 4.68; 95% CI, 1.47-14.86).	Oxygen	176-182	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	88-94
21353244-7	2011	Maximum SBP was modeled by multivariate linear regression analysis: maximum SBP=84.8 mm Hg + 6.8 mm Hg if cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) CC genotype + 6.8 mm Hg if discharged on supplemental oxygen + 4.4 mm Hg if received inpatient glucocorticoids (P=.0002).	Oxygen	223-229	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	161-167
21626641-1	2011	PtAg bimetallic nanoparticles for oxygen reduction reaction (ORR) in alkaline media were prepared by pulse electrodeposition (PED).	Oxygen	34-40	rhomboid domain containing 3	Homo sapiens	0-4
21950100-9	2011	The authors come to the conclusion about the leading role of receptor-mediated (Fas-dependent) caspase- and p53-dependent ways of realizing apoptosis oflymphocytes induced by UV-light at doses 151 and 1510 J/m2 and active oxygen metabolites.	Oxygen	222-228	tumor protein p53	Homo sapiens	108-111
21610214-4	2011	The Schizosaccharomyces pombe orthologs of Tpa1 and Ett1, Ofd1, and its partner Nro1, respectively, have been shown to regulate the stability of the Sre1 transcription factor in response to oxygen levels.	Oxygen	190-196	Ett1p	Saccharomyces cerevisiae S288C	52-56
21610214-4	2011	The Schizosaccharomyces pombe orthologs of Tpa1 and Ett1, Ofd1, and its partner Nro1, respectively, have been shown to regulate the stability of the Sre1 transcription factor in response to oxygen levels.	Oxygen	190-196	Ett1p	Saccharomyces cerevisiae S288C	80-84
21333760-3	2011	Oxygen consumption differed significantly only in females at P15 when it was reduced in 5HTT nulls (P&lt;0.01).	Oxygen	0-6	cyclin dependent kinase inhibitor 2B	Mus musculus	61-64
21693022-0	2011	A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets.	Oxygen	20-26	insulin	Homo sapiens	47-54
21693022-8	2011	Further optimization is still needed, but calculated insulin responses to stepwise increments in the incoming glucose concentration are in good agreement with existing experimental insulin release data characterizing glucose and oxygen dependence.	Oxygen	229-235	insulin	Homo sapiens	53-60
21693022-8	2011	Further optimization is still needed, but calculated insulin responses to stepwise increments in the incoming glucose concentration are in good agreement with existing experimental insulin release data characterizing glucose and oxygen dependence.	Oxygen	229-235	insulin	Homo sapiens	181-188
21754844-1	2011	The title compound, C(9)H(22)NOP, was obtained by slow diffusion of oxygen into a toluene solution of (i)Pr(2)PNH(i)Pr.	Oxygen	68-74	prepronociceptin	Homo sapiens	29-32
21636775-2	2011	We report that crystal cells express elevated levels of Sima protein orthologous to mammalian hypoxia-inducible factor-alpha (Hif-alpha) even under conditions of normal oxygen availability.	Oxygen	169-175	similar	Drosophila melanogaster	126-135
21368293-5	2011	HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21289292-4	2011	Oxygen consumption and cellular ATP levels were reduced in BAX-deficient cells, while glycolysis was increased.	Oxygen	0-6	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
21289292-9	2011	Expression of either full-length or COOH-terminal-truncated BAX in BAX-deficient cells rescued ATP synthesis and oxygen consumption and reduced glycolytic activity, suggesting that this metabolic function of BAX was not dependent upon its COOH-terminal helix.	Oxygen	113-119	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
21512133-6	2011	We have previously identified HAF as an E3 ubiquitin ligase that binds and ubiquitinates HIF-1alpha by an oxygen and pVHL-independent mechanism, thus targeting HIF-1alpha for proteasomal degradation.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
21382012-3	2011	Hypoxia (5-1% O2) increased VEGF expression in HMVECs.	Oxygen	14-16	vascular endothelial growth factor A	Homo sapiens	28-32
21382012-4	2011	In contrast, the levels of sFlt-1 mRNA and protein in HMVECs decreased significantly as the O2 concentration fell, whereas mFlt-1 (membrane-bound Flt-1) mRNA and protein remained unchanged.	Oxygen	92-94	fms related receptor tyrosine kinase 1	Homo sapiens	28-33
21443541-8	2011	The PANC-1 and MIA PaCa-2 pancreatic cancer cell lines showed &gt;2-fold higher Insig2 mRNA expression levels under hypoxic conditions (1% O2) than under normoxic conditions (21% O2 ).	Oxygen	139-141	insulin induced gene 2	Homo sapiens	80-86
21472683-1	2011	Cytoglobin/stellate cell activation-associated protein (Cygb/STAP), a hemoprotein, functions as part of an O2 reservoir with protective effects against oxidative stress in hepatic stellate cells.	Oxygen	107-109	cytoglobin	Homo sapiens	0-10
21472683-1	2011	Cytoglobin/stellate cell activation-associated protein (Cygb/STAP), a hemoprotein, functions as part of an O2 reservoir with protective effects against oxidative stress in hepatic stellate cells.	Oxygen	107-109	cytoglobin	Homo sapiens	11-54
21472683-1	2011	Cytoglobin/stellate cell activation-associated protein (Cygb/STAP), a hemoprotein, functions as part of an O2 reservoir with protective effects against oxidative stress in hepatic stellate cells.	Oxygen	107-109	cytoglobin	Homo sapiens	56-60
25961263-6	2011	In the present study, we report that the dual inhibitory effect exerted by sildenafil on both XO and PDE-5 is a consequence of a structural modification induced by O2 -, also consisting of the release of a piperazine group that could in turn inhibit the XO enzyme.	Oxygen	164-166	phosphodiesterase 5A	Homo sapiens	101-106
21472683-1	2011	Cytoglobin/stellate cell activation-associated protein (Cygb/STAP), a hemoprotein, functions as part of an O2 reservoir with protective effects against oxidative stress in hepatic stellate cells.	Oxygen	107-109	cytoglobin	Homo sapiens	61-65
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Oxygen	110-116	TBL1X/Y related 1	Homo sapiens	132-136
21511332-7	2011	SAPK activity increases transiently with FGF4 removal at 2% O(2), but SAPK activity decreases when O(2) is switched from 20% to 2% with FGF4 present.	Oxygen	60-64	mitogen-activated protein kinase 9	Homo sapiens	0-4
21511332-7	2011	SAPK activity increases transiently with FGF4 removal at 2% O(2), but SAPK activity decreases when O(2) is switched from 20% to 2% with FGF4 present.	Oxygen	99-103	mitogen-activated protein kinase 9	Homo sapiens	70-74
21511332-7	2011	SAPK activity increases transiently with FGF4 removal at 2% O(2), but SAPK activity decreases when O(2) is switched from 20% to 2% with FGF4 present.	Oxygen	99-103	fibroblast growth factor 4	Homo sapiens	136-140
21555542-6	2011	Bound HD1 and hirugen alter Trp(148) orientation in a loop near exosite I preventing contacts with the sulfate oxygen atoms of Tys(279).	Oxygen	111-117	histone deacetylase 1	Homo sapiens	6-9
21576354-2	2011	We report that DNA-PK is activated by mild hypoxia conditions (0.1-1% O2) as shown by (1) its autophosphorylation on Ser2056, and (2) its mobilisation from a soluble nucleoplasmic compartment to a less extractable nuclear fraction.	Oxygen	70-72	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	15-21
21576354-7	2011	Our results show that hypoxia initiates chromatin modification and consequently DNA-PK activation, which positively regulate cellular oxygen-sensing and oxygen-signalling pathways.	Oxygen	134-140	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	80-86
21576354-7	2011	Our results show that hypoxia initiates chromatin modification and consequently DNA-PK activation, which positively regulate cellular oxygen-sensing and oxygen-signalling pathways.	Oxygen	153-159	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	80-86
21633661-2	2011	Increased production of oxygen-derived free radicals due to ethanol metabolism by CYP2E1 is principally located in the cytoplasm and in the mitochondria, which does not only injure liver cells, but also other vital organs, such as the heart and the brain.	Oxygen	24-30	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	82-88
21446712-6	2011	Molecular dynamics simulations indicate that binding of the steroid nucleus perpendicular to the plane of the CYP21A2 heme ring limits access of the heme oxygen to the C-21 hydrogen atoms.	Oxygen	154-160	TBL1X/Y related 1	Homo sapiens	168-172
21711908-2	2011	The densely packed layers of InN-w nanostructures (5-40 nm) are shown to be oxidized by atmospheric oxygen via the formation of an intermediate amorphous In-Ox-Ny (indium oxynitride) phase to a final bi-phase hcp-InN/bcc-In2O3 nanotexture.	Oxygen	100-106	growth hormone releasing hormone	Homo sapiens	29-32
21711908-2	2011	The densely packed layers of InN-w nanostructures (5-40 nm) are shown to be oxidized by atmospheric oxygen via the formation of an intermediate amorphous In-Ox-Ny (indium oxynitride) phase to a final bi-phase hcp-InN/bcc-In2O3 nanotexture.	Oxygen	100-106	growth hormone releasing hormone	Homo sapiens	213-216
21294852-12	2011	Increased O(2) tension suppresses the EPO concentration 3 and 5 h after the exposure; thereafter EPO seems to change in a manner consistent with natural diurnal variation.	Oxygen	10-14	erythropoietin	Homo sapiens	38-41
21575165-13	2011	Blocking of potassium channels with TEA (tetraethylammounium chloride)(10 muM) inhibited vasodilation to O2 lowering as well as to NO.	Oxygen	105-107	latexin	Homo sapiens	74-77
21575165-14	2011	The superoxide scavenger tiron (10 muM) and the putative NADPH oxidase inhibitor apocynin (10 muM) leftward shifted concentration-response curves for O2 lowering without changing vasodilation to 1% O2.	Oxygen	150-152	latexin	Homo sapiens	35-38
21575165-14	2011	The superoxide scavenger tiron (10 muM) and the putative NADPH oxidase inhibitor apocynin (10 muM) leftward shifted concentration-response curves for O2 lowering without changing vasodilation to 1% O2.	Oxygen	150-152	latexin	Homo sapiens	94-97
21412525-0	2011	Damage of aromatic amino acids by the atmospheric free radical oxidant NO3  in the presence of NO2 , N2O4, O3 and O2.	Oxygen	96-98	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
21406725-0	2011	Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC.	Oxygen	0-6	erythropoietin	Homo sapiens	35-49
21406725-4	2011	In the present study, we present the human kidney cell line REPC (for renal Epo-producing cells), established from an explanted human kidney exhibiting EPO gene expression and release of the EPO protein in an oxygen-dependent manner.	Oxygen	209-215	erythropoietin	Homo sapiens	76-79
21406725-4	2011	In the present study, we present the human kidney cell line REPC (for renal Epo-producing cells), established from an explanted human kidney exhibiting EPO gene expression and release of the EPO protein in an oxygen-dependent manner.	Oxygen	209-215	erythropoietin	Homo sapiens	152-155
21406725-4	2011	In the present study, we present the human kidney cell line REPC (for renal Epo-producing cells), established from an explanted human kidney exhibiting EPO gene expression and release of the EPO protein in an oxygen-dependent manner.	Oxygen	209-215	erythropoietin	Homo sapiens	191-194
21294852-1	2011	AIM: The purpose of the present study was to evaluate the "normobaric oxygen paradox" theory by investigating the effect of a 2-h normobaric O(2) exposure on the concentration of plasma erythropoietin (EPO).	Oxygen	70-76	erythropoietin	Homo sapiens	186-200
21542902-0	2011	Tumor necrosis factor-alpha enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells.	Oxygen	48-54	tumor necrosis factor	Homo sapiens	0-27
21542902-0	2011	Tumor necrosis factor-alpha enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells.	Oxygen	48-54	mitogen-activated protein kinase 8	Homo sapiens	87-90
21169273-10	2011	Simulated ischaemia (60 min oxygen/glucose deprivation) caused a reduction at 24 h in both THY-1 mRNA and the numbers of NeuN-labelled neurons of HORCs.	Oxygen	28-34	RNA binding fox-1 homolog 3	Homo sapiens	121-125
21318419-2	2011	On the contrary, endothelial cells are especially adept at surviving conditions of oxygen deprivation via up-regulation of vascular endothelial growth factor (VEGF) the most potent endothelial survival factor.	Oxygen	83-89	vascular endothelial growth factor A	Homo sapiens	123-157
21318419-2	2011	On the contrary, endothelial cells are especially adept at surviving conditions of oxygen deprivation via up-regulation of vascular endothelial growth factor (VEGF) the most potent endothelial survival factor.	Oxygen	83-89	vascular endothelial growth factor A	Homo sapiens	159-163
21318295-7	2011	We conclude that increased cardiac oxygen utilisation, and thereby decreased cardiac efficiency, occurs in non-genetic obesity, which is associated with increased mitochondrial uncoupling due to elevated UCP3 and MTE-1 levels.	Oxygen	35-41	acyl-CoA thioesterase 2	Rattus norvegicus	213-218
21486225-7	2011	Overexpression of Bcl-2 increases mitochondrial oxygen consumption and in doing so generates a slight pro-oxidant intracellular milieu, which promotes genomic instability and blocks death signalling.	Oxygen	48-54	BCL2 apoptosis regulator	Homo sapiens	18-23
20950656-4	2011	Abeta undergoes a self-aggregation process and concomitantly generates reactive oxygen species that can trigger membrane-associated oxidative stress which, in turn, impairs the functions of ion-motive ATPases and glutamate and glucose transporters thereby rendering neurons vulnerable to excitotoxicity and apoptosis.	Oxygen	80-86	amyloid beta precursor protein	Homo sapiens	0-5
21132545-0	2011	The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes.	Oxygen	25-31	heat shock protein family A (Hsp70) member 1A	Homo sapiens	51-72
21619415-2	2011	We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical monooxygenase product serving as a coupling link.	Oxygen	42-48	endothelin 1	Homo sapiens	104-116
21247928-2	2011	Human mitochondrial thioredoxin reductase (TXNRD2) is a selenocysteine-containing enzyme essential for mitochondrial oxygen radical scavenging.	Oxygen	117-123	thioredoxin reductase 2	Homo sapiens	43-49
21324713-8	2011	In accordance with our previous results of NO induction by EPO at low oxygen tension in human umbilical vein endothelial cells and bone marrow endothelial cells, these results provide further evidence in HMVEC-L for EPO regulation of NO production to modify the effects of hypoxia and cause compensatory vasoconstriction.	Oxygen	70-76	erythropoietin	Homo sapiens	59-62
21471739-3	2011	In order to address this problem, isolated rat islets were transfected with a plasmid encoding cytoglobin, an intracellular oxygen binding protein.	Oxygen	124-130	cytoglobin	Rattus norvegicus	95-105
21316481-6	2011	We here found that the HIF-1alpha-FIH interaction is disrupted in 1-5% oxygen.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
21316481-8	2011	Furthermore, because the pVHL-FIH interaction depends on oxygen tension, the FIH-mediated inactivation of HIF-1alpha can be exquisitely regulated according to the severity of hypoxia.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
21316481-9	2011	Based on these findings, we propose that pVHL fine-tunes the transcriptional activity of HIF-1alpha in graded oxygen tensions.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
21498502-0	2011	Increase in endogenous erythropoietin synthesis through the normobaric oxygen paradox in cardiac surgery patients.	Oxygen	71-77	erythropoietin	Homo sapiens	23-37
21618402-0	2011	Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport.	Oxygen	0-6	hemoglobin 2	Arabidopsis thaliana	39-43
21618402-0	2011	Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport.	Oxygen	92-98	hemoglobin 2	Arabidopsis thaliana	39-43
21618402-2	2011	Despite a relatively fast autoxidation in the presence of O(2) , we were able to collect O(2) -binding curves for AHb2 in the presence of a reduction enzymatic system.	Oxygen	58-62	hemoglobin 2	Arabidopsis thaliana	114-118
21618402-2	2011	Despite a relatively fast autoxidation in the presence of O(2) , we were able to collect O(2) -binding curves for AHb2 in the presence of a reduction enzymatic system.	Oxygen	89-93	hemoglobin 2	Arabidopsis thaliana	114-118
21618402-3	2011	AHb2 binds O(2) noncooperatively with a p50 of 0.021 +- 0.003 Torr, a value consistent with a recently proposed role in O(2) transport.	Oxygen	11-15	hemoglobin 2	Arabidopsis thaliana	0-4
21357625-4	2011	Rgs16 is expressed during the last few hours of the daily fast in periportal hepatocytes, the oxygen-rich zone of the liver where lipolysis and gluconeogenesis predominate.	Oxygen	94-100	regulator of G-protein signaling 16	Mus musculus	0-5
21618402-3	2011	AHb2 binds O(2) noncooperatively with a p50 of 0.021 +- 0.003 Torr, a value consistent with a recently proposed role in O(2) transport.	Oxygen	120-124	hemoglobin 2	Arabidopsis thaliana	0-4
21618402-5	2011	Overall, our results are consistent with a role for AHb2 as an oxygen carrier, as recently proposed on the basis of experiments on AHb2-overexpressing mutants of A. thaliana.	Oxygen	63-69	hemoglobin 2	Arabidopsis thaliana	52-56
21397265-12	2011	In group Cy, baseline HSP-70i correlated with better postoperative right ventricular function (rho = 0.80; P = .009), mixed venous oxygen saturation (rho = 0.68; P = .04), and oxygen extraction ratio (rho = -0.71; P = .03).	Oxygen	131-137	heat shock protein family A (Hsp70) member 1A	Homo sapiens	22-29
21397265-12	2011	In group Cy, baseline HSP-70i correlated with better postoperative right ventricular function (rho = 0.80; P = .009), mixed venous oxygen saturation (rho = 0.68; P = .04), and oxygen extraction ratio (rho = -0.71; P = .03).	Oxygen	176-182	heat shock protein family A (Hsp70) member 1A	Homo sapiens	22-29
21490398-1	2011	Hypoxia inducible factor-1 (HIF-1) is the master transcriptional regulator of the cellular response to altered oxygen levels.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
21490398-1	2011	Hypoxia inducible factor-1 (HIF-1) is the master transcriptional regulator of the cellular response to altered oxygen levels.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21349627-0	2011	Monitoring of cerebral oxygen saturation during closed-chest and open-chest CPR.	Oxygen	23-29	cytochrome p450 oxidoreductase	Homo sapiens	76-79
21320746-3	2011	Furthermore, the expression of HIF-1alpha induced by SCF is not dependent on the oxygen level, but rather on both the PI3K/Akt and Ras/MEK/ERK signaling pathways.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
21220553-8	2011	The mean differences (SD) between the measured and calculated oxygen saturations in segments of the 100 and 150 mum tubes overlying the 20%, 60%, and 99% background reflectivities were (100 mum) -4.0% (13.4%), -6.4% (9.9%), and -5.5% (10.2%) and (150 mum) -5.3% (10.8%), -5.2% (10.7%), and -5.2% (10.9%), respectively.	Oxygen	62-68	latexin	Homo sapiens	112-115
21220553-8	2011	The mean differences (SD) between the measured and calculated oxygen saturations in segments of the 100 and 150 mum tubes overlying the 20%, 60%, and 99% background reflectivities were (100 mum) -4.0% (13.4%), -6.4% (9.9%), and -5.5% (10.2%) and (150 mum) -5.3% (10.8%), -5.2% (10.7%), and -5.2% (10.9%), respectively.	Oxygen	62-68	latexin	Homo sapiens	190-193
21559462-9	2011	We conclude that OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization.	Oxygen	113-119	OS9 endoplasmic reticulum lectin	Homo sapiens	103-107
21220553-8	2011	The mean differences (SD) between the measured and calculated oxygen saturations in segments of the 100 and 150 mum tubes overlying the 20%, 60%, and 99% background reflectivities were (100 mum) -4.0% (13.4%), -6.4% (9.9%), and -5.5% (10.2%) and (150 mum) -5.3% (10.8%), -5.2% (10.7%), and -5.2% (10.9%), respectively.	Oxygen	62-68	latexin	Homo sapiens	190-193
21516287-8	2011	With the aim to resolve this problem, this work studied the ability of the human glycophorin A test to determine human blood in samples that have been treated with active oxygen.	Oxygen	171-177	glycophorin A (MNS blood group)	Homo sapiens	81-94
21614171-0	2011	Protein kinase B (akt) promotes pathological angiogenesis in murine model of oxygen-induced retinopathy.	Oxygen	77-83	thymoma viral proto-oncogene 1	Mus musculus	18-21
21614171-4	2011	We showed that in the hyperoxic phase of oxygen-induced retinopathy, the expression of Akt was greatly suppressed.	Oxygen	41-47	thymoma viral proto-oncogene 1	Mus musculus	87-90
21614171-8	2011	These results indicate that Akt play a critical role in the pathological process (vessels loss and neovascularization) of mouse model of oxygen-induced retinopathy, which may provide a valubale therapeutic tool for ischemic-induced retinal diseases.	Oxygen	137-143	thymoma viral proto-oncogene 1	Mus musculus	28-31
21338581-5	2011	It was found that neuronal damage induced by oxygen-glucose deprivation was accompanied by a significant decrease in both HIF-1alpha and HIF-3alpha mRNA levels in CA1 but not CA3 neurons.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-132
21338581-5	2011	It was found that neuronal damage induced by oxygen-glucose deprivation was accompanied by a significant decrease in both HIF-1alpha and HIF-3alpha mRNA levels in CA1 but not CA3 neurons.	Oxygen	45-51	hypoxia inducible factor 3 subunit alpha	Homo sapiens	137-147
21516287-9	2011	Our results show that the human glycophorin A test has a greater resistance to the destructive effect of the new detergents containing active oxygen; consequently, it provides an alternative to be taken into consideration in the confirmatory diagnoses of bloodstains.	Oxygen	142-148	glycophorin A (MNS blood group)	Homo sapiens	32-45
21285402-6	2011	Analysis of oxygen consumption by indirect calorimetry indicated a modest reduction in total oxygen consumption in neil1(-/-) mice that was abolished upon correction for lean body mass.	Oxygen	12-18	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	115-120
21486799-9	2011	Still, Pet-1(-/-) animals hyperventilated relative to WT (increased V(E)/V(O2)) irrespective of T(A) (P = 0.002).	Oxygen	75-77	plasmacytoma expressed transcript 1	Mus musculus	7-12
21481276-0	2011	Compound C prevents Hypoxia-Inducible Factor-1alpha protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-51
21481276-1	2011	The transcription factor Hypoxia-Inducible Factor-1alpha is a master regulator of the cellular response to low oxygen concentration.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-56
21285402-6	2011	Analysis of oxygen consumption by indirect calorimetry indicated a modest reduction in total oxygen consumption in neil1(-/-) mice that was abolished upon correction for lean body mass.	Oxygen	93-99	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	115-120
22485072-6	2011	This enabled preparation of a water-soluble oxygen probe (by staining bovine serum albumin) and a trace oxygen sensor (by coupling to amino-modified silica gel).	Oxygen	44-50	albumin	Homo sapiens	77-90
21526439-2	2011	The results showed that on each surface fraction covered by biofilm the oxygen reduction kinetics resembled a reaction catalyzed by an immobilised enzyme with high oxygen affinity (apparent Michaelis-Menten dissociation constant close to K(O(2))(M)    10 muM) and low activation energy (W   20 KJ mole(-1)).	Oxygen	72-78	latexin	Homo sapiens	255-258
21526439-2	2011	The results showed that on each surface fraction covered by biofilm the oxygen reduction kinetics resembled a reaction catalyzed by an immobilised enzyme with high oxygen affinity (apparent Michaelis-Menten dissociation constant close to K(O(2))(M)    10 muM) and low activation energy (W   20 KJ mole(-1)).	Oxygen	164-170	latexin	Homo sapiens	255-258
21404259-3	2011	We provide evidence that ectopic expression of the global metabolic sensor and processing protein mammalian target of rapamycin (mTOR), simultaneously improves key bioprocess-relevant characteristics of Chinese hamster ovary (CHO) cell-derived production cell lines such as cell growth (increased cell size and protein content), proliferation (increased cell-cycle progression), viability (decreased apoptosis), robustness (decreased sensitivity to sub-optimal growth factor and oxygen supplies) and specific productivity of secreted human glycoproteins.	Oxygen	479-485	mechanistic target of rapamycin kinase	Homo sapiens	98-127
21404259-3	2011	We provide evidence that ectopic expression of the global metabolic sensor and processing protein mammalian target of rapamycin (mTOR), simultaneously improves key bioprocess-relevant characteristics of Chinese hamster ovary (CHO) cell-derived production cell lines such as cell growth (increased cell size and protein content), proliferation (increased cell-cycle progression), viability (decreased apoptosis), robustness (decreased sensitivity to sub-optimal growth factor and oxygen supplies) and specific productivity of secreted human glycoproteins.	Oxygen	479-485	mechanistic target of rapamycin kinase	Homo sapiens	129-133
21144788-1	2011	AIM: Reactive oxygen intermediates have been implicated in mediating the destruction of insulin-producing beta cells and antioxidant nutrients thought to protect against such a process.	Oxygen	14-20	insulin	Homo sapiens	88-95
21119518-4	2011	The fresh gas flow rate was 1 l min(-1) (0.5 l min(-1) O2 + 0.5 l min(-1) N2O + desflurane) in group 1 and 3 l min(-1) (1.5 l min(-1) O2 + 1.5 l min(-1) N2O + desflurane) in group 2.	Oxygen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
21119518-4	2011	The fresh gas flow rate was 1 l min(-1) (0.5 l min(-1) O2 + 0.5 l min(-1) N2O + desflurane) in group 1 and 3 l min(-1) (1.5 l min(-1) O2 + 1.5 l min(-1) N2O + desflurane) in group 2.	Oxygen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
21119518-4	2011	The fresh gas flow rate was 1 l min(-1) (0.5 l min(-1) O2 + 0.5 l min(-1) N2O + desflurane) in group 1 and 3 l min(-1) (1.5 l min(-1) O2 + 1.5 l min(-1) N2O + desflurane) in group 2.	Oxygen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
21119518-4	2011	The fresh gas flow rate was 1 l min(-1) (0.5 l min(-1) O2 + 0.5 l min(-1) N2O + desflurane) in group 1 and 3 l min(-1) (1.5 l min(-1) O2 + 1.5 l min(-1) N2O + desflurane) in group 2.	Oxygen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
21119518-4	2011	The fresh gas flow rate was 1 l min(-1) (0.5 l min(-1) O2 + 0.5 l min(-1) N2O + desflurane) in group 1 and 3 l min(-1) (1.5 l min(-1) O2 + 1.5 l min(-1) N2O + desflurane) in group 2.	Oxygen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
21176768-1	2011	Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA.	Oxygen	122-128	tyrosine hydroxylase	Homo sapiens	0-20
21232972-3	2011	Oxygen flow of 5-10 l min(-1) administered by a paediatric intra-field catheter placed in the distal bronchi during bronchial anastomosis of the spared lobe(s), following the principles of apnoeic (hyper)oxygenated ventilation, successfully improves oxygenation without significant impairment of the operation field.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	22-28
20947680-2	2011	In this study, we demonstrated for the first time in humans (n = 9) that sEPOR is downregulated upon daytime exposure to 4 days of intermittent hypoxia (IH; 6 h day-1, cycles of 2 min of hypoxia followed by 2 min of reoxygenation; peak end-tidal oxygen tension (P(ET,O2)) 88 Torr, nadir P(ET,O2)) 45 Torr), thereby allowing EPO concentration to rise.	Oxygen	218-224	erythropoietin	Homo sapiens	74-77
20947680-2	2011	In this study, we demonstrated for the first time in humans (n = 9) that sEPOR is downregulated upon daytime exposure to 4 days of intermittent hypoxia (IH; 6 h day-1, cycles of 2 min of hypoxia followed by 2 min of reoxygenation; peak end-tidal oxygen tension (P(ET,O2)) 88 Torr, nadir P(ET,O2)) 45 Torr), thereby allowing EPO concentration to rise.	Oxygen	267-269	erythropoietin	Homo sapiens	74-77
20947680-2	2011	In this study, we demonstrated for the first time in humans (n = 9) that sEPOR is downregulated upon daytime exposure to 4 days of intermittent hypoxia (IH; 6 h day-1, cycles of 2 min of hypoxia followed by 2 min of reoxygenation; peak end-tidal oxygen tension (P(ET,O2)) 88 Torr, nadir P(ET,O2)) 45 Torr), thereby allowing EPO concentration to rise.	Oxygen	292-294	erythropoietin	Homo sapiens	74-77
21195120-5	2011	Using various reactive oxygen scavengers, we found that catalase and sodium azide effectively inhibited GABA-tea extract/Cu(II)-induced DNA degradation, suggesting the essential role of singlet oxygen and H(2)O(2) in the reaction.	Oxygen	23-29	catalase	Homo sapiens	56-64
23851206-8	2011	This property of multiple sensitivities is achieved by using a mix of two O2 sensitive luminophores in each pin-printed xerogel sensor element.	Oxygen	74-76	dynein light chain LC8-type 1	Homo sapiens	108-111
21215309-0	2011	Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.	Oxygen	28-34	NADPH--cytochrome P450 reductase	Cricetulus griseus	156-187
20617487-1	2011	The wide-spread assumption that doping with erythropoietin or blood transfusion is only effective by increasing arterial blood O2 content because of rising hematocrit is not self-evident.	Oxygen	127-129	erythropoietin	Homo sapiens	44-58
21472608-2	2011	Two novel rearrangement reactions with hydroxyl oxygen or carbonyl oxygen migrations were observed in ESI-MS/MS of the metallic adducts of DIPP-dipeptides, but not for the corresponding protonated DIPP-dipeptides.	Oxygen	48-54	nudix hydrolase 3	Homo sapiens	139-143
20978516-6	2011	Deprivation of oxygen and glucose-SD produced large FluoZin-3 increases that propagated with the event, and signals were abolished in tissues from ZnT3 knockout animals lacking synaptic Zn(2+).	Oxygen	15-21	solute carrier family 30 member 3	Homo sapiens	147-151
21063426-5	2011	Likewise, in cultured cortical neurons exposed to oxygen and glucose deprivation, MIF levels increase, and inhibition of MIF by (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) protects against cell death.	Oxygen	50-56	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	82-85
21063426-5	2011	Likewise, in cultured cortical neurons exposed to oxygen and glucose deprivation, MIF levels increase, and inhibition of MIF by (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) protects against cell death.	Oxygen	50-56	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	121-124
21146939-1	2011	The "normobaric oxygen paradox" is a dual mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-132
21319863-7	2011	The levels of these proteins, subsequently determined in fetal plasma by immunoassays, strongly correlate with the fetal blood oxygen level at birth; PAI-1 and transferrin increase with low venous pO(2) (r = -0.70, p = 0.02, and r = -0.66, p = 0.04), clusterin and fibrinogen decrease (r = 0.82, p = 0.002, and r = 0.70, p = 0.02).	Oxygen	127-133	transferrin	Homo sapiens	160-171
21146939-1	2011	The "normobaric oxygen paradox" is a dual mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
21146939-1	2011	The "normobaric oxygen paradox" is a dual mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-132
21146939-1	2011	The "normobaric oxygen paradox" is a dual mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1alpha).	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
21266576-3	2011	The response to low oxygen environment is mainly mediated by the hypoxia-inducible factor named HIF-1alpha, which activates signaling pathways leading to adaptive mechanisms in tumor cells.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
20964692-6	2011	Low oxygen plays an important role for the induction of HYD1, HYDEF and HYDG, while ADH1 and HYD2 expression was relatively insensitive to oxygen availability.	Oxygen	4-10	uncharacterized protein	Chlamydomonas reinhardtii	62-67
21437769-4	2011	HIF-1alpha protein levels were studied by Western blotting at 20% (air) or after 12 hours at 0.1% O2 (hypoxia).	Oxygen	98-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21219877-8	2011	Blood O2 saturation, pulse rate and respiratory dynamics were normalized in animals treated with PON1 compared to controls.	Oxygen	6-8	paraoxonase 1	Homo sapiens	97-101
21192320-9	2011	Caspase-3 siRNA also doubled oxygen consumption and significantly neutralized perfusate pH.	Oxygen	29-35	caspase 3	Homo sapiens	0-9
20977891-7	2011	Taken together our results show that the Cdk5/p35 complex may significantly contribute to modulation of Hif-1alpha stabilisation and impact neuronal survival during oxygen deprivation.	Oxygen	165-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
21212276-5	2011	The expression of CCN1 becomes abnormally reduced during the hyperoxic and ischemic phases of ROP modeled in the mouse eye with oxygen-induced retinopathy (OIR).	Oxygen	128-134	cellular communication network factor 1	Mus musculus	18-22
20807784-2	2011	At the blood level EPO increases the arterial O(2) content not only by increasing red blood cell volume, but also by an equally important decrease in plasma volume.	Oxygen	46-50	erythropoietin	Homo sapiens	19-22
20807784-5	2011	Thus, treatment with EPO may result in suppression of endogenous EPO production through a decrease in intrarenal oxygen consumption.	Oxygen	113-119	erythropoietin	Homo sapiens	21-24
20807784-5	2011	Thus, treatment with EPO may result in suppression of endogenous EPO production through a decrease in intrarenal oxygen consumption.	Oxygen	113-119	erythropoietin	Homo sapiens	65-68
21210027-0	2011	Carbon-supported Pt^Ag nanostructures as cathode catalysts for oxygen reduction reaction.	Oxygen	63-69	rhomboid domain containing 3	Homo sapiens	17-22
26596305-10	2011	Moreover, this model also provides a plausible explanation for how structurally diverse core motifs that all share the carbonyl atoms O2 and O3 bind to FKBP12.	Oxygen	134-136	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	152-158
21138765-2	2011	Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (hypoxia) and is found over expressed in hypoxic regions of many tumors.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-80
21167179-2	2011	The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake.	Oxygen	108-114	vascular endothelial growth factor A	Homo sapiens	46-80
21167179-2	2011	The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake.	Oxygen	108-114	vascular endothelial growth factor A	Homo sapiens	82-86
20518705-7	2011	Reintroduction of oxygen generates reactive oxygen species that activate protein kinase C to increase sensitivity of adenosine A(2b) receptors allowing adenosine released from ischemic cells to bind leading to activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.	Oxygen	18-24	mitogen-activated protein kinase 3	Homo sapiens	258-299
21211514-0	2011	Explaining the enigmatic K(M) for oxygen in cytochrome c oxidase: a kinetic model.	Oxygen	34-40	cytochrome c, somatic	Homo sapiens	44-56
21138765-2	2011	Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (hypoxia) and is found over expressed in hypoxic regions of many tumors.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
20795759-7	2011	The expression of VEGF and IGF-1 was up-regulated in ASC cultured at 1% oxygen for 13 days compared with 4 days.	Oxygen	72-78	vascular endothelial growth factor A	Homo sapiens	18-22
20795759-7	2011	The expression of VEGF and IGF-1 was up-regulated in ASC cultured at 1% oxygen for 13 days compared with 4 days.	Oxygen	72-78	insulin like growth factor 1	Homo sapiens	27-32
20352258-2	2011	Mitochondrial production of ROS stabilizes the O(2)-regulated HIF-1alpha subunit of the HIF-1 dimer promoting transaction functions in a large number of potential target genes, activating transcription of sequences into RNA and, eventually, protein production.	Oxygen	47-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
21430823-0	2011	Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms" Tumor Gene, WT1.	Oxygen	0-6	WT1 transcription factor	Homo sapiens	104-107
21129992-12	2011	Vasopressin adversely correlated with systemic oxygen-transport variables and SsO(2) (p &lt; 0.05).	Oxygen	47-53	arginine vasopressin	Homo sapiens	0-11
21129992-15	2011	Aggressive use of vasopressin may worsen systemic oxygen transport and decrease splanchnic perfusion.	Oxygen	50-56	arginine vasopressin	Homo sapiens	18-29
21406623-7	2011	All germinating seeds of the kp1 and vdac3 mutants had increased oxygen consumption; the respiration balance between the cytochrome pathway and the alternative oxidase pathway was disrupted, and the ATP level was reduced.	Oxygen	65-71	kinesin-like protein 1	Arabidopsis thaliana	29-32
21245297-4	2011	Brain areas showing blood-oxygen level-dependent signals, a validated method to assess neuronal activity elicited by pain, were significantly reduced as early as 24 h after an infusion of a monoclonal antibody to TNF-alpha.	Oxygen	26-32	tumor necrosis factor	Homo sapiens	213-222
21152606-8	2011	Carbon dioxide transfer within the device was 156 ml min(-1) m(-2) and the oxygen transfer was 34 ml min(-1) m(-2).	Oxygen	75-81	CD59 molecule (CD59 blood group)	Homo sapiens	101-107
21205621-8	2011	Under low external oxygen, AHb2 overexpression maintained an up to 5-fold higher energy state and prevented fermentation.	Oxygen	19-25	hemoglobin 2	Arabidopsis thaliana	27-31
21205621-9	2011	This is consistent with AHb2 overexpression results in improved oxygen availability within developing seeds.	Oxygen	64-70	hemoglobin 2	Arabidopsis thaliana	24-28
21510275-0	2011	Different activation of ERK1/2 and p38 with hyperbaric oxygen in dorsal root ganglion.	Oxygen	55-61	mitogen-activated protein kinase 3	Homo sapiens	24-30
21510275-0	2011	Different activation of ERK1/2 and p38 with hyperbaric oxygen in dorsal root ganglion.	Oxygen	55-61	mitogen-activated protein kinase 1	Homo sapiens	35-38
21510275-4	2011	Using Western blot analysis, we found that the phosphorylation levels of ERK1/2 (phospho-ERK1/2) increased significantly (p &lt; 0.05, n = 3 for each group) in the six-hour treatment of 100% oxygen at a pressure of 2.3 ATA.	Oxygen	191-197	mitogen-activated protein kinase 3	Homo sapiens	73-79
21510275-4	2011	Using Western blot analysis, we found that the phosphorylation levels of ERK1/2 (phospho-ERK1/2) increased significantly (p &lt; 0.05, n = 3 for each group) in the six-hour treatment of 100% oxygen at a pressure of 2.3 ATA.	Oxygen	191-197	mitogen-activated protein kinase 3	Homo sapiens	89-95
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	141-147	mitogen-activated protein kinase 1	Homo sapiens	30-33
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	141-147	mitogen-activated protein kinase 1	Homo sapiens	43-46
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	141-147	caspase 3	Homo sapiens	253-262
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	141-147	mitogen-activated protein kinase 1	Homo sapiens	43-46
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	318-320	mitogen-activated protein kinase 1	Homo sapiens	30-33
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	318-320	mitogen-activated protein kinase 1	Homo sapiens	43-46
21510275-5	2011	The phosphorylation levels of p38 (phospho-p38) increased significantly (p &lt; 0.05, n = 3 for each group) in the 10-hour treatment of 100% oxygen at a pressure of 2.3 ATA--which was consistent with time course changes of an apoptosis marker, cleavage caspase-3--while the phospho-p38 decreased in the 10 hours of N2-O2 mixture.	Oxygen	318-320	mitogen-activated protein kinase 1	Homo sapiens	43-46
21510275-6	2011	These results demonstrate that the ERK1/2 and p38 have been differently activated in the DRG by prolonged hyperbaric oxygen exposure.	Oxygen	117-123	mitogen-activated protein kinase 3	Homo sapiens	35-41
21510275-6	2011	These results demonstrate that the ERK1/2 and p38 have been differently activated in the DRG by prolonged hyperbaric oxygen exposure.	Oxygen	117-123	mitogen-activated protein kinase 1	Homo sapiens	46-49
21609620-10	2011	RESULTS: The mouse treated with PRR siRNA, Losartan and combined therapy could significantly reduce retina neovascularization and vessel leakage compared with oxygen-induced retinopathy group and control plasmid group.	Oxygen	159-165	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	32-35
21430823-4	2011	As such, the Wilms" tumor gene, WT1, is among the fetal genes that are regulated by the local oxygen tension.	Oxygen	94-100	WT1 transcription factor	Homo sapiens	32-35
21430823-14	2011	This article shall provide a concise review of the function of WT1 in development and disease with special consideration of its regulation by molecular oxygen.	Oxygen	152-158	WT1 transcription factor	Homo sapiens	63-66
21341853-3	2011	Although the hydrogen bond energy and the distance of the nearest-neighbor oxygen pair are significantly different for TIP4P and GCP models, they approach to similar ground state structures and melting transition temperatures in cluster sizes we considered.	Oxygen	75-81	golgin B1	Homo sapiens	129-132
21265562-6	2011	Docking of heme onto a high-resolution structure of the G-quadruplex fold of Bcl-2 promoter DNA, which both binds heme and transfers oxygen, suggests a relatively open active site for this class of ribozymes and deoxyribozymes.	Oxygen	133-139	BCL2 apoptosis regulator	Homo sapiens	77-82
21281640-5	2011	We show that iron-dependent decay of tetracycline-inducible IRP2 proceeds efficiently under mild hypoxic conditions (3% oxygen) but is compromised in severe hypoxia (0.1% oxygen).	Oxygen	120-126	iron responsive element binding protein 2	Homo sapiens	60-64
21281640-5	2011	We show that iron-dependent decay of tetracycline-inducible IRP2 proceeds efficiently under mild hypoxic conditions (3% oxygen) but is compromised in severe hypoxia (0.1% oxygen).	Oxygen	171-177	iron responsive element binding protein 2	Homo sapiens	60-64
21281640-8	2011	These data demonstrate that the degradation of IRP2 in iron-replete cells is not only oxygen-dependent but also sensitive to redox perturbations.	Oxygen	86-92	iron responsive element binding protein 2	Homo sapiens	47-51
21182313-12	2011	Despite the long triplet lifetimes of the CINH(+)/HSA complexes, the rate constant of quenching by oxygen was found to be 2 orders of magnitude lower than that determined in acetonitrile, which can be attributed to the relative slower diffusion rates in this microheterogeneous system.	Oxygen	99-105	albumin	Homo sapiens	50-53
21269829-1	2011	Ero1p, using molecular oxygen as its preferred terminal electron acceptor, promotes disulfide bond formation by interaction with protein disulfide isomerase.	Oxygen	23-29	ER oxidoreductin	Saccharomyces cerevisiae S288C	0-5
21180730-0	2011	Catalytic dioxygen activation by Co(II) complexes employing a coordinatively versatile ligand scaffold.	Oxygen	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
21303984-2	2011	Numerous studies have shown that hypoxia-inducible factor 1alpha (HIF-1alpha), an oxygen-sensitive transcription factor, is overexpressed in various types of human cancers and upregulates a battery of hypoxia-responsive genes for the growth and survival of cancer cells.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-64
21303984-2	2011	Numerous studies have shown that hypoxia-inducible factor 1alpha (HIF-1alpha), an oxygen-sensitive transcription factor, is overexpressed in various types of human cancers and upregulates a battery of hypoxia-responsive genes for the growth and survival of cancer cells.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
21281817-6	2011	These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-117
21059645-6	2011	Over 24 h, MitoVES caused stabilization of the oxygen-dependent destruction domain of HIF1alpha fused to GFP, indicating promotion of the state of pseudohypoxia.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-95
21289181-5	2011	On the autonomic side, Trpv1 KO mice were hypometabolic (had a lower oxygen consumption) and hypervasoconstricted (had a lower tail skin temperature).	Oxygen	69-75	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
21192937-6	2011	Hypoxia dependent Txnip down-regulation may be an important compensatory mechanism through which cancer cells adapt their metabolism to low oxygen concentrations.	Oxygen	140-146	thioredoxin interacting protein	Homo sapiens	18-23
20640462-1	2011	Beta-amyloid (Abeta) is considered to be responsible for the pathogenesis of Alzheimer"s disease (AD), and accumulation and aggregation of Abeta peptide in the brains of AD patients result in activation of glial cells which, in turn, initiates neuroinflammatory responses that involve reactive oxygen intermediates and release of inflammatory cytokines.	Oxygen	294-300	amyloid beta precursor protein	Homo sapiens	14-19
20640462-1	2011	Beta-amyloid (Abeta) is considered to be responsible for the pathogenesis of Alzheimer"s disease (AD), and accumulation and aggregation of Abeta peptide in the brains of AD patients result in activation of glial cells which, in turn, initiates neuroinflammatory responses that involve reactive oxygen intermediates and release of inflammatory cytokines.	Oxygen	294-300	amyloid beta precursor protein	Homo sapiens	139-144
21281801-4	2011	In contrast, PEDF-Tg animals with oxygen-induced retinopathy (OIR) developed significantly less severe retinal neovascularization compared with wild-type (Wt) mice with OIR.	Oxygen	34-40	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	13-17
21281817-6	2011	These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC.	Oxygen	42-48	ubiquitin conjugating enzyme E2 S	Homo sapiens	141-147
20348209-0	2011	Activation of Akt protects alveoli from neonatal oxygen-induced lung injury.	Oxygen	49-55	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
21048020-11	2011	In a human proximal tubular cell culture, we show that PEDF downregulates HIF1alpha protein and gene expression in cells exposed to 1% oxygen.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-83
20348209-7	2011	Conversely, in an experimental model of BPD induced by oxygen exposure of newborn rats, alveolar simplification is associated with a decreased activation of lung Akt.	Oxygen	55-61	AKT serine/threonine kinase 1	Rattus norvegicus	162-165
20348209-8	2011	In vitro studies with rat lung epithelial (RLE) cells cultured in hyperoxia (95% O(2)) showed decreased apoptosis and improved cell survival after the forced expression of active Akt by adenovirus-mediated gene transfer.	Oxygen	81-85	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
21148070-3	2011	Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-117
21112084-3	2011	With hydrogen peroxide as substrate, we observed oxygen gas bubbles were generated from hydrogen peroxide decomposed by Pt-Ft; the generation of oxygen gas strongly supports Pt-Ft reacts as catalase, other than peroxidase.	Oxygen	49-55	catalase	Homo sapiens	190-198
21112084-3	2011	With hydrogen peroxide as substrate, we observed oxygen gas bubbles were generated from hydrogen peroxide decomposed by Pt-Ft; the generation of oxygen gas strongly supports Pt-Ft reacts as catalase, other than peroxidase.	Oxygen	145-151	catalase	Homo sapiens	190-198
21219576-0	2011	Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-kappaB activity in pancreatic islets depends on oxygen availability.	Oxygen	135-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
21148070-3	2011	Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
21158590-11	2011	CONCLUSIONS: Cultured retinal cells up-regulate their VEGF production when their energy supply, including glucose and/or O(2), is inadequate.	Oxygen	121-125	vascular endothelial growth factor A	Homo sapiens	54-58
21158590-12	2011	Supplying glucose to the cells in the presence of low O(2) reduces their VEGF production.	Oxygen	54-58	vascular endothelial growth factor A	Homo sapiens	73-77
21158590-1	2011	PURPOSE: To study the relationship of oxygen level and glucose concentration on the secretion of vascular endothelial growth factor (VEGF) mRNA and protein in several types of cultured retinal cells.	Oxygen	38-44	vascular endothelial growth factor A	Homo sapiens	97-131
21158590-1	2011	PURPOSE: To study the relationship of oxygen level and glucose concentration on the secretion of vascular endothelial growth factor (VEGF) mRNA and protein in several types of cultured retinal cells.	Oxygen	38-44	vascular endothelial growth factor A	Homo sapiens	133-137
21449473-4	2011	A multivariate mixed model analysis of variance indicated that the SRP and NO3- -N concentrations were controlled primarily by three classes of variables: environmental variables, including precipitation and water table depth; source variables, including manure applied and crop type; and chemical variables, including DOC and dissolved oxygen concentrations in groundwater.	Oxygen	337-343	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
21228800-2	2011	Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.	Oxygen	270-276	angiotensinogen	Rattus norvegicus	173-179
21228800-2	2011	Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.	Oxygen	270-276	angiotensinogen	Rattus norvegicus	315-321
20199782-7	2011	Fetuin-A was significantly higher (~20%) in both young and older LO men compared with their HI counterparts, and fetuin-A was inversely related to maximal oxygen uptake (r = -0.40, P = .014).	Oxygen	155-161	alpha 2-HS glycoprotein	Homo sapiens	113-121
21052705-0	2011	5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner.	Oxygen	5-11	arachidonate 5-lipoxygenase activating protein	Mus musculus	35-39
21052705-4	2011	We hypothesized that a 5-lipoxygenase-activating protein (FLAP) inhibitor given while newborn mice were exposed to 85% oxygen would prevent aberrant alveolarization in a dose- and time-dependent manner.	Oxygen	28-34	arachidonate 5-lipoxygenase activating protein	Mus musculus	58-62
21347709-8	2011	The percentage of cells positive for active caspase-3, which was high during normoxia (21% O(2)), gradually decreased when hESCs were continuously cultured under mild hypoxia.	Oxygen	91-96	caspase 3	Homo sapiens	44-53
21142119-3	2011	Co K-edge EXAFS data show that both 1 and 2 are side-on O2-bound cobalt(III) peroxide complexes.	Oxygen	56-58	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	72-75
21205613-7	2011	On the other hand, the combined deletion of HPR1, HPR2, and HPR3 causes increased growth retardation, decreased photochemical efficiency, and reduced oxygen-dependent gas exchange in comparison with the hpr1xhpr2 double mutant.	Oxygen	150-156	nuclear matrix protein-like protein	Arabidopsis thaliana	44-48
21081489-9	2011	Experiments to identify how miR-200b modulates angiogenesis under a low oxygen environment illustrated that hypoxia-induced miR-200b down-regulation de-repressed Ets-1 expression to promote angiogenesis.	Oxygen	72-78	microRNA 200b	Homo sapiens	28-36
21081489-9	2011	Experiments to identify how miR-200b modulates angiogenesis under a low oxygen environment illustrated that hypoxia-induced miR-200b down-regulation de-repressed Ets-1 expression to promote angiogenesis.	Oxygen	72-78	microRNA 200b	Homo sapiens	124-132
21298084-1	2011	Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
21298084-1	2011	Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21230000-5	2011	In the presence of oxygen, the sensitivity of these sensors for measuring low levels of RSNOs (&lt;muM) is greatly reduced.	Oxygen	19-25	latexin	Homo sapiens	99-102
20888325-8	2011	HIF-1alpha protein levels were reduced by NO-sulindac exposure and radiation at 21 and 0.2% oxygen.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21051333-7	2011	Pde6b(rd1/rd1) retinal explants cultured in 6% O(2) showed 31% less PR death than normoxic explants.	Oxygen	47-51	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	0-5
21051333-7	2011	Pde6b(rd1/rd1) retinal explants cultured in 6% O(2) showed 31% less PR death than normoxic explants.	Oxygen	47-51	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	6-9
21051333-7	2011	Pde6b(rd1/rd1) retinal explants cultured in 6% O(2) showed 31% less PR death than normoxic explants.	Oxygen	47-51	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	10-13
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21169549-2	2011	In transformed cells, MIF was shown to modulate and to be modulated via the oxygen-sensitive transcription factor hypoxia-inducible factor (HIF)-1.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-146
21149600-2	2011	Hypoxia contributes to inflammation through the regulation of gene expression via key oxygen-sensitive transcriptional regulators including the hypoxia-inducible factor (HIF) and NF-kappaB.	Oxygen	86-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	179-188
21141873-1	2011	Glycolate oxidase is a flavin-dependent enzyme that catalyzes the oxidation of alpha-hydroxy acids to the corresponding alpha-keto acids, with reduction of molecular oxygen to hydrogen peroxide.	Oxygen	166-172	hydroxyacid oxidase 2	Homo sapiens	0-17
21205697-1	2011	One rationale behind the use of agents that inhibit vascular endothelial growth factor in the therapy of primary CNS malignancies is based upon the concept that normalization of tumor vasculature with a decrease in tumor interstitial pressure will improve access of cytoreductive drugs and improve radiotherapy efficacy due to increased oxygen delivery.	Oxygen	337-343	vascular endothelial growth factor A	Homo sapiens	52-86
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21586359-9	2011	As such, the ADORA(2B) has emerged as a therapeutic target for dampening hypoxia-induced inflammation and tissue adaptation to limited oxygen availability.	Oxygen	135-141	adenosine A2b receptor	Homo sapiens	13-21
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21248371-3	2011	The levels of HIF-1alpha subunit are increased in most solid tumors not only by low oxygen but also by growth factors and oncogenes and correlate with patient prognosis and treatment failure.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
21445801-2	2011	In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo.	Oxygen	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
20939709-3	2011	EPO transcription, in turn, is regulated by a distinctive oxygen-sensing mechanism.	Oxygen	58-64	erythropoietin	Homo sapiens	0-3
21525597-5	2011	Using cytokine protein arrays and real time gene expression analysis, we indeed found that low oxygen exposure increased expression of characteristic macrophage inflammatory cytokines such as IL-1, IL-6, and TNF-alpha.	Oxygen	95-101	interleukin 6	Homo sapiens	198-202
22040890-1	2011	Catalase protects cells from reactive oxygen species-induced damage by catalyzing the breakdown of hydrogen peroxide to oxygen and water.	Oxygen	38-44	catalase	Homo sapiens	0-8
21525597-5	2011	Using cytokine protein arrays and real time gene expression analysis, we indeed found that low oxygen exposure increased expression of characteristic macrophage inflammatory cytokines such as IL-1, IL-6, and TNF-alpha.	Oxygen	95-101	tumor necrosis factor	Homo sapiens	208-217
21084864-3	2011	HIF-1alpha expression allows metabolic adaptation to low oxygen availability, partly through upregulation of VEGF and increased tumor angiogenesis.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21617322-6	2011	Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively).	Oxygen	192-198	fatty acid binding protein 3	Homo sapiens	54-60
21248471-3	2011	To develop an effective and low cytotoxic biological agent for targeted therapy, a p53 fusion protein, which was conjugated with the minimum motif of oxygen-dependent degradation domain (ODD) and the basic domain of TAT of HIV-1 named as TAT-ODD-p53, was evaluated for the treatment of NSCLC established by grafting H1299 cell line in which TP53 is homozygously deleted.	Oxygen	150-156	tumor protein p53	Homo sapiens	83-86
20671746-3	2011	Culture of human CD34(+) cells at low O(2) concentrations (O(2) &lt;=3%) maintains stem cell engraftment potential better than at 20% O(2) (NOD/Scid xenograft model).	Oxygen	38-42	CD34 molecule	Homo sapiens	17-21
22178933-3	2011	HIF-1alpha/ beta and HIF-2alpha/ beta are transcriptional activators of oxygen-regulated genes.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21785006-1	2011	The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this process in metazoan species is hypoxia-inducible factor 1 (HIF-1), which controls both O(2) delivery and utilization.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-154
21785006-1	2011	The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this process in metazoan species is hypoxia-inducible factor 1 (HIF-1), which controls both O(2) delivery and utilization.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-161
21785006-2	2011	Under conditions of reduced O(2) availability, HIF-1 activates the transcription of genes, whose protein products mediate a switch from oxidative to glycolytic metabolism.	Oxygen	28-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-52
21861815-1	2011	Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
21625097-3	2011	The antioxidant properties of these membranes have an important clinical benefit because of reducing oxygen stress and inflammation may contribute to an improvement of hemoglobin levels, lower recombinant human erythropoietin dose and better anemia management, and at the same time may have a favorable impact on cardiovascular complications.	Oxygen	101-107	erythropoietin	Homo sapiens	211-225
21861815-1	2011	Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21861815-2	2011	HIF-1, a heterodimer consisting of a constitutively expressed beta subunit and an oxygen-regulated alpha subunit, regulates a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Oxygen	0-6	protein regulator of cytokinesis 1	Mus musculus	120-131
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Oxygen	0-6	cyclin dependent kinase inhibitor 2A	Mus musculus	170-173
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Oxygen	0-6	cyclin dependent kinase inhibitor 2A	Mus musculus	174-179
21046429-2	2011	Abiotic reduction of As(V) (0.1 mM) to As(III) by aqueous Fe(II) and sorbed Fe(II) in pH range 5.0-7.0 and Fe(II)(aq) concentration (0.6-1.2 mM) was investigated along with the effect of As(V) on the oxidation of Fe(II) by dissolved oxygen (DO).	Oxygen	233-239	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	21-26
21797710-1	2011	We describe a high oxygen affinity hemoglobin (Hb) variant (Hb Vanderbilt) as a result of a heterozygous novel base change from T to A at codon 89 (AGT&gt;AGA) leading to an amino acid change from serine to arginine.	Oxygen	19-25	angiotensinogen	Homo sapiens	148-151
21687640-1	2011	Superoxide dismutase (SOD, EC 1.15.1.1) plays an important antioxidant defense role in skins exposed to oxygen.	Oxygen	104-110	superoxide dismutase 1	Homo sapiens	0-20
21687640-1	2011	Superoxide dismutase (SOD, EC 1.15.1.1) plays an important antioxidant defense role in skins exposed to oxygen.	Oxygen	104-110	superoxide dismutase 1	Homo sapiens	22-25
20888935-5	2011	Here, we report on a male patient aged 6 years presenting with a mosaic nonsense mutation c.994delG within the FLNA gene, PH and severe congenital lung disease comprising bilateral atelectasis, lung cysts, tracheobronchomalacia, pulmonary arterial hypertension and long-term oxygen dependence; histology of resected lung showed panpulmonary emphysema with marked reduction of bronchial cartilage.	Oxygen	275-281	filamin A	Homo sapiens	111-115
21196394-2	2011	Boron-doped diamond (BDD) electrodes exhibit outstanding properties compared to oxygen-containing sp2 carbon electrodes.	Oxygen	80-86	Sp2 transcription factor	Homo sapiens	98-101
20525945-1	2011	Cytochrome c oxidase is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c.	Oxygen	128-134	cytochrome c, somatic	Homo sapiens	0-12
22174616-5	2011	PGC-1alpha overexpression resulted in increased mitochondrial mass, reactive oxygen species production, and oxygen consumption.	Oxygen	77-83	PPARG coactivator 1 alpha	Homo sapiens	0-10
20966191-1	2011	Erythropoietin (Epo) is produced primarily in the kidneys upon low blood oxygen availability and stimulates erythropoiesis in the bone marrow.	Oxygen	73-79	erythropoietin	Homo sapiens	0-14
20966191-1	2011	Erythropoietin (Epo) is produced primarily in the kidneys upon low blood oxygen availability and stimulates erythropoiesis in the bone marrow.	Oxygen	73-79	erythropoietin	Homo sapiens	16-19
20966191-2	2011	Recombinant human Epo (rHuEpo), a drug developed to increase arterial oxygen content in patients, is also illicitly used by athletes to improve their endurance performance.	Oxygen	70-76	erythropoietin	Homo sapiens	18-21
22272128-3	2011	SOD-1 catalyses the superoxide radical (O(-2)) into hydrogen peroxide and molecular oxygen.	Oxygen	40-45	superoxide dismutase 1	Homo sapiens	0-5
22272128-3	2011	SOD-1 catalyses the superoxide radical (O(-2)) into hydrogen peroxide and molecular oxygen.	Oxygen	84-90	superoxide dismutase 1	Homo sapiens	0-5
22553628-0	2011	Role of unc5b in retinal neovascularization in mice with oxygen-induced retinopathy.	Oxygen	57-63	unc-5 netrin receptor B	Mus musculus	8-13
22553628-1	2011	AIM: To explore the role of unc5b in retinal neovascularization in murine oxygen-induced retinopathy (OIR).	Oxygen	74-80	unc-5 netrin receptor B	Mus musculus	28-33
21253945-4	2011	The involvement of active oxygen in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, catalase, thiourea, sodium azide, potassium iodide, and sodium benzoate.	Oxygen	26-32	catalase	Homo sapiens	124-132
20525945-1	2011	Cytochrome c oxidase is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c.	Oxygen	128-134	cytochrome c, somatic	Homo sapiens	146-158
20661932-0	2011	Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1beta and p38 MAPK signal.	Oxygen	33-39	interleukin 1 beta	Homo sapiens	106-114
21391037-3	2011	The degree of aeration was also estimated, and the role of dissolved oxygen in AIRP performance is discussed.	Oxygen	69-75	5'-nucleotidase, cytosolic IB	Homo sapiens	79-83
21088376-0	2011	Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-alpha is partially oxygen dependent.	Oxygen	119-125	tumor necrosis factor	Homo sapiens	96-105
21088376-5	2011	Similar to priming by endotoxin, priming of the respiratory burst by TNF-alpha was predominantly oxygen dependent, with marked attenuation of ROS generation if primed anaerobically.	Oxygen	97-103	tumor necrosis factor	Homo sapiens	69-78
20661932-0	2011	Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1beta and p38 MAPK signal.	Oxygen	33-39	mitogen-activated protein kinase 14	Homo sapiens	119-122
21422725-4	2011	Additional oxygen sensitive signaling pathways including mammalian target of rapamycin (mTOR) signaling and signaling through activation of the unfolded protein response (UPR) also contribute to the adaptation in the tumor microenvironment.	Oxygen	11-17	mechanistic target of rapamycin kinase	Homo sapiens	57-86
21043802-2	2011	It is composed of an oxygen-sensitive alpha subunit (HIF-1alpha) and a constitutively expressed beta subunit.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
21422725-4	2011	Additional oxygen sensitive signaling pathways including mammalian target of rapamycin (mTOR) signaling and signaling through activation of the unfolded protein response (UPR) also contribute to the adaptation in the tumor microenvironment.	Oxygen	11-17	mechanistic target of rapamycin kinase	Homo sapiens	88-92
21422728-4	2011	Interestingly, some of the histone demethylase enzymes, which have the Jumonji domain-containing family, require oxygen to function and are induced by hypoxia in an HIF-1-dependent manner.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	165-170
21209911-5	2010	This downregulatory effect was abolished when the oxygen-dependent domain (ODD) of HIF-1alpha (HIF-1alpha-DeltaODD, the domain responsible for HIF-1alpha degradation) was experimentally deleted or when the activity of HIF-1alpha prolyl hydroxylase (PHD) or the 26S proteasomal complex was inhibited, indicating that the 1, 9 PA downregulates HIF-1alpha by promoting PHD-dependent HIF-1alpha degradation.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
20978083-2	2011	The u-ATP9 transgene driven by A9 and APETALA3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and adenine nucleotides (ATP, ADP) levels without changes in the ATP/ADP ratio.	Oxygen	121-127	ATPase subunit 9	Arabidopsis thaliana	6-10
20351613-12	2011	Significant positive correlations exist between sPLA2, TNF-alpha and oxygen need, mean airway pressure, ventilatory index, and the Murray"s lung injury score.	Oxygen	69-75	tumor necrosis factor	Homo sapiens	55-64
20351613-14	2011	CONCLUSIONS: The sPLA2 and TNF-alpha are increased in ARDS and seem correlated with clinical severity, higher oxygen requirement, and more aggressive ventilation.	Oxygen	110-116	phospholipase A2 group X	Homo sapiens	17-22
20351613-14	2011	CONCLUSIONS: The sPLA2 and TNF-alpha are increased in ARDS and seem correlated with clinical severity, higher oxygen requirement, and more aggressive ventilation.	Oxygen	110-116	tumor necrosis factor	Homo sapiens	27-36
22022615-5	2011	Depression of oxygen consumption rate and upregulation of heat shock protein genes (hsps) occurred in sequence when ambient temperature was increased from 24 to 30 C. Large-scale mortality of the sea cucumber occurred when temperatures rose beyond 30 C, suggesting that the upregulation of heat shock proteins and mortality are closely related to the depression of aerobic metabolism, a phenomenon that is in line with the concept of oxygen- and capacity-limited thermal tolerance (OCLTT).	Oxygen	434-440	heat shock 70 kDa protein, mitochondrial	Cucumis sativus	58-76
21799876-5	2011	Recent evidence shows that SCF triggers accumulation of the inducible alpha subunit of hypoxia-inducible factor 1 (HIF-1) in hematopoietic cells--a transcription complex that plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	226-232	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-120
21694754-6	2011	After four weeks of calorie-restricted feeding, oxygen consumption and locomotor activity were elevated in AGRPPdk1(-/-) mice and reduced in Delta256Foxo1(AGRP)Pdk1(-/-) mice.	Oxygen	48-54	agouti related neuropeptide	Mus musculus	107-111
21694754-6	2011	After four weeks of calorie-restricted feeding, oxygen consumption and locomotor activity were elevated in AGRPPdk1(-/-) mice and reduced in Delta256Foxo1(AGRP)Pdk1(-/-) mice.	Oxygen	48-54	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	111-115
21346313-5	2011	Furthermore, we documented that both iron chelators significantly attenuated the elevated iron level and transferrin receptor expression, decreased oxygen free radicals and suppressed microglial and astrocytic activation in the spinal cords of the SOD1(G93A) mice.	Oxygen	148-154	superoxide dismutase 1, soluble	Mus musculus	248-252
21966417-3	2011	HIF-1 is also induced in an oxygen-independent manner through the activation of epidermal growth factor receptor tyrosine kinase (EGFR-TK).	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21966417-3	2011	HIF-1 is also induced in an oxygen-independent manner through the activation of epidermal growth factor receptor tyrosine kinase (EGFR-TK).	Oxygen	28-34	epidermal growth factor receptor	Homo sapiens	130-134
22016779-1	2011	We have previously shown that a massive increase in global SUMOylation occurs during torpor in ground squirrels, and that overexpression of Ubc9 and/or SUMO-1 in cell lines and cortical neurons protects against oxygen and glucose deprivation.	Oxygen	211-217	small ubiquitin-like modifier 1	Mus musculus	152-158
21804324-4	2011	We have found that apelin/APJ system is involved in not only physiological but also pathological retinal angiogenesis using a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	141-147	apelin receptor	Mus musculus	26-29
21209911-5	2010	This downregulatory effect was abolished when the oxygen-dependent domain (ODD) of HIF-1alpha (HIF-1alpha-DeltaODD, the domain responsible for HIF-1alpha degradation) was experimentally deleted or when the activity of HIF-1alpha prolyl hydroxylase (PHD) or the 26S proteasomal complex was inhibited, indicating that the 1, 9 PA downregulates HIF-1alpha by promoting PHD-dependent HIF-1alpha degradation.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
21209911-5	2010	This downregulatory effect was abolished when the oxygen-dependent domain (ODD) of HIF-1alpha (HIF-1alpha-DeltaODD, the domain responsible for HIF-1alpha degradation) was experimentally deleted or when the activity of HIF-1alpha prolyl hydroxylase (PHD) or the 26S proteasomal complex was inhibited, indicating that the 1, 9 PA downregulates HIF-1alpha by promoting PHD-dependent HIF-1alpha degradation.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
21176170-0	2010	The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	65-99
21179168-2	2010	In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor, from l-arginine (l-Arg) by means of electron transfer from NADPH through a flavin containing reductase domain to oxygen bound at the haem of an oxygenase domain, which also contains binding sites for tetrahydrobiopterin (BH(4)) and l-Arg.	Oxygen	206-212	nitric oxide synthase 3	Homo sapiens	38-42
21176170-0	2010	The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	101-105
21151608-8	2010	Nine hours after oxygen-assisted resuscitation, caspase-3 expression and activity was increased by 30-40% in the 100% O(2) group (n = 9/10) vs. the 21% O(2) group (n = 10; p&lt;0.04), whereas brain-derived neurotrophic factor (BDNF) activity was decreased by 65% p&lt;0.03.	Oxygen	17-23	caspase 3	Homo sapiens	48-57
21082809-6	2010	The magnetic susceptibility and solid-state/frozen solution EPR data on 1 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin of S = 1/2.	Oxygen	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
25214984-2	2011	Neuroglobin (NGB) is an oxygen-binding heme protein found in the brain with a protection role against ischemic-hypoxic brain injury.	Oxygen	24-30	neuroglobin	Rattus norvegicus	0-11
25214984-2	2011	Neuroglobin (NGB) is an oxygen-binding heme protein found in the brain with a protection role against ischemic-hypoxic brain injury.	Oxygen	24-30	neuroglobin	Rattus norvegicus	13-16
25214996-15	2011	In addition, the level of plasma vWF was positively correlated with platelet count, but negatively correlated with oxygen index.	Oxygen	115-121	von Willebrand factor	Homo sapiens	33-36
25214996-16	2011	The level of serum IL-8 was positively correlated with white blood cell count and ISS score, and inversely correlated with oxygen index.	Oxygen	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
20962028-3	2010	HIF-1alpha and HIF-2alpha undergo oxygen-dependent regulation, and their overexpression is frequently associated with metastasis and poor clinical outcomes.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21149533-1	2010	BACKGROUND: The production of erythropoietin is triggered by impaired oxygen delivery to the kidney, either because of anemia or hypoxemia.	Oxygen	70-76	erythropoietin	Homo sapiens	30-44
21070073-1	2010	In the present work, we have designed and synthesized a new highly durable iron phtalocyanine based nonprecious oxygen reduction reaction (ORR) catalyst (Fe-SPc) for polymer electrolyte membrane fuel cells (PEMFCs).	Oxygen	112-118	proline rich protein gene cluster	Homo sapiens	157-160
21070073-2	2010	The Fe-SPc, with a novel structure inspired by that of naturally occurring oxygen activation catalysts, is prepared by a nonpyrolyzing method, allowing adequate control of the atomic structure and surface properties of the material.	Oxygen	75-81	proline rich protein gene cluster	Homo sapiens	7-10
20963248-0	2010	Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(eta1-ONO2), even at ~100 K. The oxy-globin models Fe(Por)(NH(3))(O(2)), prepared by sequential reactions of O(2) ((18)O(2)) and NH(3) with thin porous layers of Fe(II)(Por), react with NO ((15)NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH(3))(eta(1)-ONO(2)), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog.	Oxygen	46-48	cytochrome p450 oxidoreductase	Homo sapiens	36-39
20963248-0	2010	Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(eta1-ONO2), even at ~100 K. The oxy-globin models Fe(Por)(NH(3))(O(2)), prepared by sequential reactions of O(2) ((18)O(2)) and NH(3) with thin porous layers of Fe(II)(Por), react with NO ((15)NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH(3))(eta(1)-ONO(2)), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog.	Oxygen	46-48	cytochrome p450 oxidoreductase	Homo sapiens	100-103
20963248-0	2010	Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(eta1-ONO2), even at ~100 K. The oxy-globin models Fe(Por)(NH(3))(O(2)), prepared by sequential reactions of O(2) ((18)O(2)) and NH(3) with thin porous layers of Fe(II)(Por), react with NO ((15)NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH(3))(eta(1)-ONO(2)), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog.	Oxygen	46-48	cytochrome p450 oxidoreductase	Homo sapiens	100-103
20963248-0	2010	Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(eta1-ONO2), even at ~100 K. The oxy-globin models Fe(Por)(NH(3))(O(2)), prepared by sequential reactions of O(2) ((18)O(2)) and NH(3) with thin porous layers of Fe(II)(Por), react with NO ((15)NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH(3))(eta(1)-ONO(2)), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog.	Oxygen	46-48	cytochrome p450 oxidoreductase	Homo sapiens	100-103
20963248-0	2010	Hexacoordinate oxy-globin models Fe(Por)(NH3)(O2) react with NO to form only the nitrato analogs Fe(Por)(NH3)(eta1-ONO2), even at ~100 K. The oxy-globin models Fe(Por)(NH(3))(O(2)), prepared by sequential reactions of O(2) ((18)O(2)) and NH(3) with thin porous layers of Fe(II)(Por), react with NO ((15)NO) at 80-100 K to form only the low-spin nitrato complexes Fe(Por)(NH(3))(eta(1)-ONO(2)), thus implying that peroxynitrite intermediates, if formed, must undergo very facile isomerization to the nitrato analog.	Oxygen	46-48	cytochrome p450 oxidoreductase	Homo sapiens	100-103
21151608-8	2010	Nine hours after oxygen-assisted resuscitation, caspase-3 expression and activity was increased by 30-40% in the 100% O(2) group (n = 9/10) vs. the 21% O(2) group (n = 10; p&lt;0.04), whereas brain-derived neurotrophic factor (BDNF) activity was decreased by 65% p&lt;0.03.	Oxygen	118-122	caspase 3	Homo sapiens	48-57
20869263-8	2010	Patients with low FKN levels showed significantly higher levels of oxygen saturation in room air compared to patients with high FKN levels (p&lt;0.05).	Oxygen	67-73	C-X3-C motif chemokine ligand 1	Homo sapiens	18-21
20881034-2	2010	We observed increased kidney oxygen consumption (Q(O2)) and altered renal hemodynamics in the A/I kidney that were normalized after combined angiotensin II (ANG II) blockade.	Oxygen	51-53	angiotensinogen	Homo sapiens	157-163
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	fibroblast growth factor 2	Homo sapiens	97-102
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	mitogen-activated protein kinase kinase 7	Homo sapiens	103-106
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	mitogen-activated protein kinase 3	Homo sapiens	107-114
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	nuclear factor kappa B subunit 1	Homo sapiens	115-124
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	protein kinase C alpha	Homo sapiens	129-132
20497028-0	2010	Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways.	Oxygen	11-17	mitogen-activated protein kinase 8	Homo sapiens	133-136
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	fibroblast growth factor 2	Homo sapiens	78-110
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	AKT serine/threonine kinase 1	Homo sapiens	151-154
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	mitogen-activated protein kinase 3	Homo sapiens	181-184
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	nuclear factor kappa B subunit 1	Homo sapiens	186-212
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	protein kinase C alpha	Homo sapiens	232-241
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	mitogen-activated protein kinase 8	Homo sapiens	262-285
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	mitogen-activated protein kinase 8	Homo sapiens	287-290
20881034-6	2010	Treatment with DMOG, CoCl(2), and ANG II blockade normalized kidney oxygen consumption factored by Na reabsorption and increased both renal blood flow and glomerular filtration rate.	Oxygen	68-74	angiotensinogen	Homo sapiens	34-40
20861024-1	2010	A phosphodiesterase (PDE) from Escherichia coli (Ec DOS) is a novel haem-based oxygen sensor enzyme.	Oxygen	79-85	phosphodiesterase	Escherichia coli	2-19
20696493-7	2010	These findings will help to tailor PetF for achieving an optimized photobiotechnological hydrogen production in C. reinhardtii, which might also benefit from new insights into the mechanism of how oxygen attacks the active site metal cluster of HydA1.	Oxygen	197-203	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21115615-2	2010	A better understanding of EPO regulation, namely oxygen-dependent hydroxylation of the hypoxia-inducible transcription factor (HIF), may enable targeted pharmacological intervention.	Oxygen	49-55	erythropoietin	Homo sapiens	26-29
24489484-8	2010	This property of multiple sensitivities is achieved by using a strategic mix of two oxygen sensitive luminophores ([Ru(dpp)3]2+ and ([Ru(bpy)3]2+) in each pin-printed xerogel sensor element.	Oxygen	84-90	dynein light chain LC8-type 1	Homo sapiens	155-158
20656555-5	2010	Our findings not only provide insight into the synergistic functions of SOD and peroxidase but also could potentially be used to develop novel therapeutic agents with more efficient O2 carrying capability.	Oxygen	182-184	superoxide dismutase 1	Homo sapiens	72-90
20861024-1	2010	A phosphodiesterase (PDE) from Escherichia coli (Ec DOS) is a novel haem-based oxygen sensor enzyme.	Oxygen	79-85	phosphodiesterase	Escherichia coli	21-24
21030877-2	2010	However, evidence supports the concept that signaling via the androgen receptor (AR) is important in progression to castration-resistant prostate cancer (CRPC).Steroid hormones are synthesized from cholesterol in a series of tightly regulated steps involving the cleavage of carbon-carbon bonds, the introduction of functional groups derived from activated molecular oxygen, and the oxidation and reduction of carbon-carbon and carbon-oxygen bonds.	Oxygen	367-373	androgen receptor	Homo sapiens	62-79
20861024-2	2010	Binding of O(2) to the reduced haem in the sensor domain enhances PDE activity exerted by the catalytic domain.	Oxygen	11-15	phosphodiesterase	Escherichia coli	66-69
20686497-4	2010	Culture for 5 days at 2% oxygen is perceived as hypoxia and significantly reduced myofibroblast differentiation and contraction despite high levels of the profibrotic transforming growth factor-beta1.	Oxygen	25-31	transforming growth factor beta 1	Homo sapiens	167-199
21030877-2	2010	However, evidence supports the concept that signaling via the androgen receptor (AR) is important in progression to castration-resistant prostate cancer (CRPC).Steroid hormones are synthesized from cholesterol in a series of tightly regulated steps involving the cleavage of carbon-carbon bonds, the introduction of functional groups derived from activated molecular oxygen, and the oxidation and reduction of carbon-carbon and carbon-oxygen bonds.	Oxygen	367-373	androgen receptor	Homo sapiens	81-83
21030877-2	2010	However, evidence supports the concept that signaling via the androgen receptor (AR) is important in progression to castration-resistant prostate cancer (CRPC).Steroid hormones are synthesized from cholesterol in a series of tightly regulated steps involving the cleavage of carbon-carbon bonds, the introduction of functional groups derived from activated molecular oxygen, and the oxidation and reduction of carbon-carbon and carbon-oxygen bonds.	Oxygen	435-441	androgen receptor	Homo sapiens	62-79
21030877-2	2010	However, evidence supports the concept that signaling via the androgen receptor (AR) is important in progression to castration-resistant prostate cancer (CRPC).Steroid hormones are synthesized from cholesterol in a series of tightly regulated steps involving the cleavage of carbon-carbon bonds, the introduction of functional groups derived from activated molecular oxygen, and the oxidation and reduction of carbon-carbon and carbon-oxygen bonds.	Oxygen	435-441	androgen receptor	Homo sapiens	81-83
21124777-1	2010	Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell adaptation to low oxygen and stabilization of HIF-1 is vital to ensure cell survival under hypoxia.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20980400-0	2010	TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1alpha pathway.	Oxygen	76-82	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	0-4
20980400-0	2010	TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1alpha pathway.	Oxygen	76-82	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	9-14
20980400-0	2010	TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1alpha pathway.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
20805787-3	2010	After hyperoxic exposure (O2 &gt;95%), nuclear NF-kappaB consensus sequence binding increased and was associated with IkappaBalpha degradation.	Oxygen	26-28	nuclear factor kappa B subunit 1	Homo sapiens	47-56
20805787-3	2010	After hyperoxic exposure (O2 &gt;95%), nuclear NF-kappaB consensus sequence binding increased and was associated with IkappaBalpha degradation.	Oxygen	26-28	NFKB inhibitor alpha	Homo sapiens	118-130
21128791-7	2010	Radiation does not increase apoptosis in BPAEC but inhibits cell growth and up-regulates p53 and p21 at either 3% or 20% oxygen.	Oxygen	121-127	cyclin dependent kinase inhibitor 1A	Bos taurus	97-100
20807796-1	2010	INTRODUCTION: Angiotensin II (AngII) regulates blood pressure and water and electrolyte metabolism through the stimulation of NAD(P)H oxidase and production of reactive oxygen species (ROS) such as O2-, which is metabolised by superoxide dismutase, catalase and glutathione peroxidase.	Oxygen	198-200	angiotensinogen	Rattus norvegicus	14-28
20807796-1	2010	INTRODUCTION: Angiotensin II (AngII) regulates blood pressure and water and electrolyte metabolism through the stimulation of NAD(P)H oxidase and production of reactive oxygen species (ROS) such as O2-, which is metabolised by superoxide dismutase, catalase and glutathione peroxidase.	Oxygen	198-200	angiotensinogen	Rattus norvegicus	30-35
20937770-7	2010	CPEB4 is necessary for cell survival and becomes nuclear in response to focal ischemia in vivo and when cultured neurons are deprived of oxygen and glucose.	Oxygen	137-143	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	0-5
21124777-1	2010	Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell adaptation to low oxygen and stabilization of HIF-1 is vital to ensure cell survival under hypoxia.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20974954-7	2010	This study shows that IFN-gamma effector functions on intracellular C. trachomatis depend on the environmental oxygen supply, which could explain inadequate bacterial clearance and subsequent chronic infections eventually occurring in the UGT of women.	Oxygen	111-117	interferon gamma	Homo sapiens	22-31
20732396-6	2010	SFN was also able to prevent the CIS-induced mitochondrial alterations both in LLC-PK1 cells (loss of membrane potential) and in isolated mitochondria (inhibition of mitochondrial calcium uptake, release of cytochrome c, and decrease in GSH content, aconitase activity, adenosine triphosphate (ATP) content and oxygen consumption).	Oxygen	311-317	cytokine inducible SH2 containing protein	Sus scrofa	33-36
21068326-2	2010	In this study, we investigated the role of Na(+)/H(+) exchanger isoform 1 (NHE-1) in activation of microglia after lipopolysaccharide (LPS) or oxygen and glucose deprivation and reoxygenation (OGD/REOX) exposure.	Oxygen	143-149	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	43-73
21068326-2	2010	In this study, we investigated the role of Na(+)/H(+) exchanger isoform 1 (NHE-1) in activation of microglia after lipopolysaccharide (LPS) or oxygen and glucose deprivation and reoxygenation (OGD/REOX) exposure.	Oxygen	143-149	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	75-80
20923173-8	2010	In the first binding motif, WT1, the Mg2+ ion is coordinated to D352beta, zinc-bound D297beta, two water molecules, and one oxygen atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).	Oxygen	124-130	WT1 transcription factor	Homo sapiens	28-31
20532951-10	2010	The reaction of protein radicals formed on insulin, beta-lactoglobulin, pepsin, chymotrypsin and bovine serum albumin with ascorbate is relatively rapid, competes with the reaction with dioxygen, and the relatively innocuous ascorbyl radical is formed.	Oxygen	186-194	insulin	Homo sapiens	43-50
21057730-3	2010	CD73 activity is primarily regulated at the level of transcription in response to the oxygen-sensing transcription factor HIF1, and its tissue-specific expression correlates negatively with oxygen tension.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-126
20810912-6	2010	Compared with 20% oxygen, exposure of syncytiotrophoblasts to &lt;1% oxygen upregulated hypoxia-inducible factor (HIF)-1alpha and rapidly downregulated p53.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-125
20810912-6	2010	Compared with 20% oxygen, exposure of syncytiotrophoblasts to &lt;1% oxygen upregulated hypoxia-inducible factor (HIF)-1alpha and rapidly downregulated p53.	Oxygen	69-75	tumor protein p53	Homo sapiens	152-155
20832062-6	2010	After 30 days of treatment, group B showed higher levels of adiponectin which is inversely correlated to reduced levels of sgp91(phox), urinary isoprostanes and platelet oxygen free radicals (p&lt;0.001).	Oxygen	170-176	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
20367259-7	2010	Mutant SOD1 localization in the IMS is not dictated by oxygen concentration and the Mia40/Erv1 system, but is primarily dependent on aberrant protein folding and aggregation.	Oxygen	55-61	superoxide dismutase 1	Homo sapiens	7-11
20680307-6	2010	In WT, TNFalpha reduced State 3 respiration from 279.3 +- 3 to 119.3 +- 2 (nmol O2/mg protein/min), increased proton leak from 15.7 +- 0.6% (control) to 36.6 +- 4.4%, and decreased membrane potential by 20.5 +- 3.1% compared to control groups.	Oxygen	80-82	tumor necrosis factor	Mus musculus	7-15
20578983-3	2010	The expression, activity and stability of HIF-1 is not only induced in response to reduced oxygen availability but also modulated through PI-3K, MAPK, autocrine signaling pathways, E3 ubiquitin ligases, and other regulators.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-47
22043202-5	2010	Available information suggests that when tissue oxygen supply is limited, mitochondria emanate signals involving reactive oxygen species generation which in turn stabilizes oxygen sensing transcription factor HIF-1.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-214
22043202-5	2010	Available information suggests that when tissue oxygen supply is limited, mitochondria emanate signals involving reactive oxygen species generation which in turn stabilizes oxygen sensing transcription factor HIF-1.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-214
22043202-6	2010	Upon stabilization, HIF-1 elicits necessary genetic response to cope with the diminished oxygen level.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
20833896-8	2010	These results clearly indicate that Crr1 is involved in the transcriptional regulation of the FDX5 gene in the absence of oxygen or copper.	Oxygen	122-128	uncharacterized protein	Chlamydomonas reinhardtii	94-98
20679134-1	2010	Heme oxygenase 1 (HO-1) uses molecular oxygen and electrons from NADPH cytochrome P450 reductase to convert heme to CO, ferrous iron, and biliverdin (BV).	Oxygen	5-11	cytochrome p450 oxidoreductase	Homo sapiens	65-96
20972325-1	2010	Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1).	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-145
21132643-3	2010	Recent research has demonstrated that cerebral astrocytes and skin keratocytes can also produce erythropoietin as a response to different oxygen concentrations.	Oxygen	138-144	erythropoietin	Homo sapiens	96-110
21132643-4	2010	Therefore, it is possible to hypothesize a skin-brain-kidney link which, through erythropoietin production, modulates the oxygen contribution to tissues.	Oxygen	122-128	erythropoietin	Homo sapiens	81-95
20972325-1	2010	Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1).	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-152
20972325-2	2010	HIF-1 expression is also controlled by specific microRNAs and, in turn, controls the expression of other microRNAs, which fine-tune adaptation to low oxygen tension.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
20972332-1	2010	The mammalian target of rapamycin (mTOR) is a signaling molecule that senses environmental cues, such as nutrient status and oxygen supply, to regulate cell growth, proliferation, and other functions.	Oxygen	125-131	mechanistic target of rapamycin kinase	Homo sapiens	4-33
20972332-1	2010	The mammalian target of rapamycin (mTOR) is a signaling molecule that senses environmental cues, such as nutrient status and oxygen supply, to regulate cell growth, proliferation, and other functions.	Oxygen	125-131	mechanistic target of rapamycin kinase	Homo sapiens	35-39
20972335-3	2010	Mammalian cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates genes governing angiogenesis and metabolic pathways.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-147
20972335-3	2010	Mammalian cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates genes governing angiogenesis and metabolic pathways.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
20972335-4	2010	Oxygen-dependent changes in HIF-1alpha levels are regulated by proline hydroxylation and proteasomal degradation.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
20637870-6	2010	The present study provides the first evidence supporting the hypothesis that autophagy and apoptosis can be differentially induced by 4-HPR under different oxygen conditions; mediated by HIF-1alpha, 4-HPR-induced autophagy under hypoxia confers a survival advantage to HeLa cells, protects them from 4-HPR-induced death signals, and thus contributes to their hypoxia-induced resistance to this agent.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
21141287-2	2010	This polymer formation is associated with a marked right-shifted oxyhemoglobin dissociation curve (decreased affinity, increased P50), which results in a decrease in arterial oxygen saturation (SaO2.	Oxygen	175-181	nuclear factor kappa B subunit 1	Homo sapiens	129-132
21141287-4	2010	This theoretical study, which views SCA as a disease of oxygen transport, provides a novel framework to suggest that a small to modest increase in cardiac index (by decreasing the P50 and thus increasing the SaO2) could change the distribution of the delay times (sec) such that the balance between occlusion and opening of microcirculatory vessels is shifted favoring the opening of these vessels, therefore disfavoring vaso-occlusion.	Oxygen	56-62	nuclear factor kappa B subunit 1	Homo sapiens	180-183
21307646-4	2010	Growth factors, amino acids, cellular nutrients, and oxygen deficiency can down-regulate mTOR activity.	Oxygen	53-59	mechanistic target of rapamycin kinase	Homo sapiens	89-93
20889540-6	2010	CXCR7 protein is, however, expressed on mouse primitive erythroid cells, which supply oxygen to the embryo during early stages of development.	Oxygen	86-92	atypical chemokine receptor 3	Mus musculus	0-5
21588853-1	2010	The Pb(II )atom in the title compound, {[Pb(2)(C(7)H(6)NO(2))(4)]}(n), is chelated by two 3-aminobenzoato ligands in a distorted pentagonal-bipyramidal coordination geometry with five oxygen donors in the equatorial positions, one nitro-gen donor and one oxygen donor in the axial positions.	Oxygen	184-190	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-11
21284207-1	2010	Microbial catalase is an important industrial enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Oxygen	120-126	catalase	Homo sapiens	10-18
20801873-1	2010	Cells are responding to hypoxia via prolyl-4-hydroxylase domain (PHD) enzymes, which are responsible for oxygen-dependent hydroxylation of the hypoxia-inducible factor (HIF)-1alpha subunit.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-180
20827750-6	2010	Our results indicate that MDB-derived precursor cells require hypoxic conditions for in vitro expansion, whereas acute exposure to 20% oxygen induces tumor cell differentiation and death through inhibition of Notch signaling.	Oxygen	135-141	notch receptor 1	Homo sapiens	209-214
21588853-1	2010	The Pb(II )atom in the title compound, {[Pb(2)(C(7)H(6)NO(2))(4)]}(n), is chelated by two 3-aminobenzoato ligands in a distorted pentagonal-bipyramidal coordination geometry with five oxygen donors in the equatorial positions, one nitro-gen donor and one oxygen donor in the axial positions.	Oxygen	255-261	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-11
20965424-1	2010	The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling.	Oxygen	169-175	mechanistic target of rapamycin kinase	Homo sapiens	42-46
20967267-3	2010	HIF-1alpha stability is controlled by O(2)-sensing enzymes including prolyl hydroxylases (PHDs), Factor Inhibiting HIF (FIH), and E3 ligases Seven In Absentia Homologues (SIAHs).	Oxygen	38-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20938491-3	2010	Previous work has shown that sediment oxygen demand (SOD) is elevated in instream floodplain swamps and due to these areas of intense oxygen demand, these locations play a major role in determining the oxygen balance of the watershed as a whole.	Oxygen	38-44	superoxide dismutase 1	Homo sapiens	53-56
20938491-3	2010	Previous work has shown that sediment oxygen demand (SOD) is elevated in instream floodplain swamps and due to these areas of intense oxygen demand, these locations play a major role in determining the oxygen balance of the watershed as a whole.	Oxygen	134-140	superoxide dismutase 1	Homo sapiens	53-56
20938491-3	2010	Previous work has shown that sediment oxygen demand (SOD) is elevated in instream floodplain swamps and due to these areas of intense oxygen demand, these locations play a major role in determining the oxygen balance of the watershed as a whole.	Oxygen	134-140	superoxide dismutase 1	Homo sapiens	53-56
20967245-0	2010	Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen species.	Oxygen	61-67	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
20967245-1	2010	The bi-enzymatic system of cytochrome P450 (CYP, a hemoprotein) and cytochrome P450 reductase (CPR, a diflavoenzyme) mediate the redox metabolism of diverse indigenous and xenobiotic molecules in various cellular and organ systems, using oxygen and NADPH.	Oxygen	238-244	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-42
20967245-1	2010	The bi-enzymatic system of cytochrome P450 (CYP, a hemoprotein) and cytochrome P450 reductase (CPR, a diflavoenzyme) mediate the redox metabolism of diverse indigenous and xenobiotic molecules in various cellular and organ systems, using oxygen and NADPH.	Oxygen	238-244	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-47
20967245-1	2010	The bi-enzymatic system of cytochrome P450 (CYP, a hemoprotein) and cytochrome P450 reductase (CPR, a diflavoenzyme) mediate the redox metabolism of diverse indigenous and xenobiotic molecules in various cellular and organ systems, using oxygen and NADPH.	Oxygen	238-244	cytochrome p450 oxidoreductase	Homo sapiens	68-93
20967245-1	2010	The bi-enzymatic system of cytochrome P450 (CYP, a hemoprotein) and cytochrome P450 reductase (CPR, a diflavoenzyme) mediate the redox metabolism of diverse indigenous and xenobiotic molecules in various cellular and organ systems, using oxygen and NADPH.	Oxygen	238-244	cytochrome p450 oxidoreductase	Homo sapiens	95-98
20967245-5	2010	We report here that CPR is capable of activating molecular oxygen on its own merit, generating diffusible reduced oxygen species (DROS).	Oxygen	59-65	cytochrome p450 oxidoreductase	Homo sapiens	20-23
20967245-5	2010	We report here that CPR is capable of activating molecular oxygen on its own merit, generating diffusible reduced oxygen species (DROS).	Oxygen	114-120	cytochrome p450 oxidoreductase	Homo sapiens	20-23
20967245-6	2010	Also, in the first instance for a flavoprotein, CPR is shown to deplete peroxide via diffusible radical mediated process, thereby leading to the formation of water (but without significant evolution of oxygen).	Oxygen	202-208	cytochrome p450 oxidoreductase	Homo sapiens	48-51
20967245-7	2010	We also quantitatively demonstrate that the rate of oxygen activation and peroxide depletion by CPR accounts for the major reactivity in the CYP+CPR mixture.	Oxygen	52-58	cytochrome p450 oxidoreductase	Homo sapiens	96-99
20967245-7	2010	We also quantitatively demonstrate that the rate of oxygen activation and peroxide depletion by CPR accounts for the major reactivity in the CYP+CPR mixture.	Oxygen	52-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	141-144
20967245-7	2010	We also quantitatively demonstrate that the rate of oxygen activation and peroxide depletion by CPR accounts for the major reactivity in the CYP+CPR mixture.	Oxygen	52-58	cytochrome p450 oxidoreductase	Homo sapiens	145-148
20967245-8	2010	We show unambiguously that CPR is able to regulate the concentration of diffusible reduced oxygen species in the reaction milieu.	Oxygen	91-97	cytochrome p450 oxidoreductase	Homo sapiens	27-30
20932347-1	2010	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha), a critical transcription factor to reduced O2 availability, has been demonstrated to be extensively involved in tumor survival, aggressive progression, drug resistance and angiogenesis.	Oxygen	101-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
20932347-1	2010	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha), a critical transcription factor to reduced O2 availability, has been demonstrated to be extensively involved in tumor survival, aggressive progression, drug resistance and angiogenesis.	Oxygen	101-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
20675386-6	2010	Thus, reestablishing mitochondrial oxygen consumption in the presence of a complex III inhibitor by using an artificial electron donor to complex IV or by overexpressing Ciona intestinalis alternative oxidase results in HIF-1alpha protein stabilization in hypoxia.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	220-230
19176260-3	2010	Adiponectin correlated inversely with peak oxygen consumption and 6-minute walking distance and was able to identify CHF patients with impaired exercise capacity.	Oxygen	43-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
20675386-1	2010	The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) is a master regulator of the cellular response to low oxygen.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-56
20675386-1	2010	The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) is a master regulator of the cellular response to low oxygen.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20675386-2	2010	HIF-1alpha protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1alpha on two conserved proline residues (Pro(402) and Pro(564)), thus targeting the protein for 26 S proteasome-dependent degradation.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
20679349-2	2010	The membrane-integrated protein gp91(phox) serves as the catalytic core, because it contains a complete electron-transporting apparatus from NADPH to molecular oxygen for superoxide production.	Oxygen	160-166	CD33 molecule	Homo sapiens	37-41
20486761-3	2010	To maintain an oxidized state, Ero1 couples disulfide transfer to PDI with reduction of molecular oxygen, forming hydrogen peroxide.	Oxygen	98-104	ER oxidoreductin	Saccharomyces cerevisiae S288C	31-35
20429727-6	2010	From here it was possible to identify a fraction of probesets induced at low oxygen independent of pH in these two cell lines, this fraction included HIG2, NDRG1, PAI1 and RORA.	Oxygen	77-83	hypoxia inducible lipid droplet associated	Homo sapiens	150-154
20973793-3	2010	In the presence of oxygen, HIF1alpha is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1alpha for proteasomal degradation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-36
20973793-3	2010	In the presence of oxygen, HIF1alpha is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1alpha for proteasomal degradation.	Oxygen	19-25	egl-9 family hypoxia inducible factor 1	Homo sapiens	63-68
20973793-3	2010	In the presence of oxygen, HIF1alpha is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1alpha for proteasomal degradation.	Oxygen	19-25	egl-9 family hypoxia inducible factor 1	Homo sapiens	82-86
20973793-3	2010	In the presence of oxygen, HIF1alpha is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1alpha for proteasomal degradation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-150
20889127-4	2010	miR-378(*) performs this function by inhibiting the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in tricarboxylic acid cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation.	Oxygen	181-187	PPARG coactivator 1 beta	Homo sapiens	70-79
20214493-5	2010	Proteins destined to the intermembrane space are trapped by a disulfide relay mechanism that involves an electron cascade from the incoming substrate to Mia40, then on to Erv1, and finally to molecular oxygen via cytochrome c.	Oxygen	202-208	cytochrome c, somatic	Homo sapiens	213-225
20885190-4	2010	Oxygen consumption (VO2, ml kg-1 min-1) was measured with steady-state VO2 requirements and responses determined using the mathematical model from the following equation: VO2 (WR) = VO2 (rest) + VO2 (unloading pedaling) + alpha.WR; DeltaVO2(t, WR) = DeltaVO2 (WR) = [1-e[-(t-td)/tO2].	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	33-38
20807755-8	2010	At 1% O(2), vascular endothelial growth factor was regulated by both HIF-1alpha and HIF-2alpha, but glucose transporter 1, carbonic anhydrase 9, and urokinase-type plasminogen activator receptor were regulated by HIF-1alpha rather than by HIF-2alpha.	Oxygen	6-10	vascular endothelial growth factor A	Homo sapiens	12-46
20599784-5	2010	We found that LW6 promoted the degradation of wild type HIF-1alpha, but not of a DM-HIF-1alpha with modifications of P402A and P564A, at hydroxylation sites in the oxygen-dependent degradation domain (ODDD).	Oxygen	164-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
20840591-0	2010	Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.	Oxygen	85-91	egl-9 family hypoxia inducible factor 1	Homo sapiens	34-79
20339099-9	2010	We hypothesize that EPO reduction by HCT is caused by a decrease in renal oxygen requirement, which is the main stimulus for EPO production, due to the inhibition of active tubular sodium reabsorption.	Oxygen	74-80	erythropoietin	Homo sapiens	20-23
20852629-10	2010	O2 availability, therefore, may have a direct role in stem cell regulation through HIF-1alpha modulation of Wnt/beta-catenin signalling.	Oxygen	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
20339099-9	2010	We hypothesize that EPO reduction by HCT is caused by a decrease in renal oxygen requirement, which is the main stimulus for EPO production, due to the inhibition of active tubular sodium reabsorption.	Oxygen	74-80	erythropoietin	Homo sapiens	125-128
20095867-4	2010	HIF-1alpha stability within the cells is under the control of a class of iron-dependent and oxygen-sensor enzymes, HIF prolyl-4-hydroxylases (PHDs) that target HIF-1alpha for degradation.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20669236-2	2010	Ero1p contains a pair of essential disulfide bonds that participate directly in the electron transfer pathway from substrate thiol groups to oxygen.	Oxygen	141-147	ER oxidoreductin	Saccharomyces cerevisiae S288C	0-5
20804197-3	2010	Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms.	Oxygen	243-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20546814-2	2010	The synthesis of HIF-1 alpha can be stimulated via oxygen (O(2))-independent mechanisms; whereas, the degradation of HIF-1 alpha is regulated via Fe(2+) and/or O(2)-dependent enzyme prolyl hydroxylase (PHD).	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-28
20546814-2	2010	The synthesis of HIF-1 alpha can be stimulated via oxygen (O(2))-independent mechanisms; whereas, the degradation of HIF-1 alpha is regulated via Fe(2+) and/or O(2)-dependent enzyme prolyl hydroxylase (PHD).	Oxygen	59-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-28
20546814-2	2010	The synthesis of HIF-1 alpha can be stimulated via oxygen (O(2))-independent mechanisms; whereas, the degradation of HIF-1 alpha is regulated via Fe(2+) and/or O(2)-dependent enzyme prolyl hydroxylase (PHD).	Oxygen	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-28
20367277-4	2010	Whereas overexpression of Bcl-2 increased mitochondrial oxygen consumption and complex IV activity, CEM/Bcl-2 cells responded to the increased mitochondrial oxidative stress induced by resveratrol by significantly reducing mitochondrial respiration, complex IV activity, and O(2)(-) production, and promoted cell survival.	Oxygen	56-62	BCL2 apoptosis regulator	Homo sapiens	26-31
20095867-4	2010	HIF-1alpha stability within the cells is under the control of a class of iron-dependent and oxygen-sensor enzymes, HIF prolyl-4-hydroxylases (PHDs) that target HIF-1alpha for degradation.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
20660157-1	2010	Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor for responses to low oxygen.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20660157-1	2010	Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor for responses to low oxygen.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20657942-2	2010	The central Co(II) ion, of each trinuclear entity, exhibits a distorted octahedral geometry, with two ligand molecules coordinating through their carbonyl oxygen atoms along with two bridging Cl(-) ions and two pyridine N atoms from the neighboring molecules.	Oxygen	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20681735-4	2010	With oxygen permeabilities as low as below 1 cm(3) mum m(-2) day(-1) kPa(-1) and with adequate mechanical properties, the films and coatings show promising property profiles for renewable packaging applications.	Oxygen	5-11	latexin	Homo sapiens	51-54
20818181-1	2010	K(V)1.2 is a potassium channel protein whose electrophysiological properties, including an oxygen sensing response, are modulated by auxiliary beta subunits.	Oxygen	91-97	potassium voltage-gated channel subfamily A member 2	Homo sapiens	0-7
20838600-10	2010	Interestingly, one gene previously known to be important in cellular oxygen sensing, EGLN1 (also known as PHD2), shows evidence of positive selection in both Tibetans and Andeans.	Oxygen	69-75	egl-9 family hypoxia inducible factor 1	Homo sapiens	85-90
20838600-10	2010	Interestingly, one gene previously known to be important in cellular oxygen sensing, EGLN1 (also known as PHD2), shows evidence of positive selection in both Tibetans and Andeans.	Oxygen	69-75	egl-9 family hypoxia inducible factor 1	Homo sapiens	106-110
20382751-4	2010	In the present work, we first showed that in vitro Bcl-2 can rescue murine pulmonary epithelial cells (MLE12) from oxygen-induced cell apoptosis, as shown by analysis of LDH release, annexin V/propidium staining, and caspase-3 activity.	Oxygen	115-121	B cell leukemia/lymphoma 2	Mus musculus	51-56
20671264-3	2010	When GBM-derived neurosphere cultures are grown in 1% oxygen, hypoxia-inducible factor 1alpha (HIF1alpha) protein levels increase dramatically, and mRNA encoding other hypoxic response genes, such as those encoding hypoxia-inducible gene-2, lysyl oxidase, and vascular endothelial growth factor, are induced over 10-fold.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-104
20671264-7	2010	We believe HIF1alpha plays a causal role in these changes, as when oxygen-stable HIF1alpha is expressed in normoxic glioma cells CD133 is induced.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-20
20671264-7	2010	We believe HIF1alpha plays a causal role in these changes, as when oxygen-stable HIF1alpha is expressed in normoxic glioma cells CD133 is induced.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-90
20400218-2	2010	Much less recognition exists for the role of the renin-angiotensin system in regulating erythropoiesis, a biological function critical for oxygen delivery to tissues.	Oxygen	139-145	renin	Homo sapiens	49-54
20339946-1	2010	BACKGROUND: The mammalian target of rapamycin (mTOR) plays central roles in the regulation of cell growth and proliferation by monitoring nutrient availability, cellular energy level, oxygen level, and mitogenic signals.	Oxygen	184-190	mechanistic target of rapamycin kinase	Homo sapiens	16-45
20339946-1	2010	BACKGROUND: The mammalian target of rapamycin (mTOR) plays central roles in the regulation of cell growth and proliferation by monitoring nutrient availability, cellular energy level, oxygen level, and mitogenic signals.	Oxygen	184-190	mechanistic target of rapamycin kinase	Homo sapiens	47-51
20576633-3	2010	METHODS: We randomized 39 ASA I-II parturients undergoing elective CS under GA to receive 30% (Gp 30), 50% (Gp 50), or 100% (Gp 100) oxygen with nitrous oxide and sevoflurane adjusted to provide equivalent minimum alveolar concentration.	Oxygen	133-139	premelanosome protein	Homo sapiens	125-131
20736373-2	2010	AhR dimerizes with HIF-1beta/AhR, which is shared with HIF-1alpha, a transcription factor critical for the response of cells to oxygen deprivation.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
20815766-2	2010	Catalase activity was evaluated by measuring oxygen from the reaction between hydrogen peroxide (H(2)O(2)) and catalase-positive cells.	Oxygen	45-51	catalase	Homo sapiens	0-8
20652949-8	2010	Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport.	Oxygen	177-183	cadherin 1	Mus musculus	18-22
20520555-8	2010	Colloid infusions (mainly HES and human albumin) at 120 min caused significant changes in central venous pressure, cardiac index, GEDVI, SVV, DO2I and central venous oxygen saturation compared with baseline.	Oxygen	166-172	albumin	Homo sapiens	40-47
20729179-9	2010	CONCLUSION: Culture of primary AML cells under low oxygen tension induces HIF-1alpha expression and increases the release of several cytokines, including proangiogenic mediators, compared to culture at ambient 21% O(2).	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
20815766-2	2010	Catalase activity was evaluated by measuring oxygen from the reaction between hydrogen peroxide (H(2)O(2)) and catalase-positive cells.	Oxygen	45-51	catalase	Homo sapiens	111-119
20875979-5	2010	Reducing gases, such as acetone, can reduce the density of ZnO through reaction with the adsorbed oxygen, leading to a lower TCF.	Oxygen	98-104	hepatocyte nuclear factor 4 alpha	Homo sapiens	125-128
20592263-1	2010	The three Drosophila atypical soluble guanylyl cyclases, Gyc-89Da, Gyc-89Db, and Gyc-88E, have been proposed to act as oxygen detectors mediating behavioral responses to hypoxia.	Oxygen	119-125	Guanylyl cyclase at 89Da	Drosophila melanogaster	57-65
20623582-7	2010	Intriguingly, the introduction of Cas DeltaSH3 induced a loss of fenestrae, the characteristic cell-penetrating pores in SECs that serve as a critical route for supplying oxygen and nutrients to hepatocytes.	Oxygen	171-177	breast cancer anti-estrogen resistance 1	Mus musculus	34-37
20557423-0	2010	Endoplasmic reticulum Ca2+ signaling and mitochondrial Cyt c release in astrocytes following oxygen and glucose deprivation.	Oxygen	93-99	cytochrome c, somatic	Homo sapiens	55-60
20679732-3	2010	Production of NO by the inducible host enzyme NOS2 is a key antimycobacterial defense mechanism that requires oxygen as a substrate; it is therefore likely to perform inefficiently in hypoxic regions of granulomas in which M. tuberculosis persists.	Oxygen	110-116	nitric oxide synthase 2, inducible	Mus musculus	46-50
20572162-3	2010	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1 alpha and HIF-1 beta, plays a critical role in oxygen homeostasis and is involved in angiogenesis and cell proliferation.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20572162-3	2010	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1 alpha and HIF-1 beta, plays a critical role in oxygen homeostasis and is involved in angiogenesis and cell proliferation.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20572162-3	2010	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1 alpha and HIF-1 beta, plays a critical role in oxygen homeostasis and is involved in angiogenesis and cell proliferation.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-97
20832523-9	2010	Vasopressin reduced cardiac output, superior mesenteric artery (SMA) blood flow and oxygen delivery, and systemic oxygen delivery and consumption, and increased oxygen extraction.	Oxygen	84-90	vasopressin	Sus scrofa	0-11
19660198-8	2010	Both N-methyl-D-aspartic acid (NMDA) receptor antagonist (ketamine) and oxygen free radical scavenger (alpha-tocopherol) decreased AMPK activity as well as the content of GLUT4 in the plasma membrane following cerebral ischemia.	Oxygen	72-78	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	131-135
20832523-12	2010	Vasopressin was associated with inadequate oxygen delivery, estimated from decreased oxygen delivery and increased oxygen extraction.	Oxygen	85-91	vasopressin	Sus scrofa	0-11
20832523-12	2010	Vasopressin was associated with inadequate oxygen delivery, estimated from decreased oxygen delivery and increased oxygen extraction.	Oxygen	43-49	vasopressin	Sus scrofa	0-11
20832523-12	2010	Vasopressin was associated with inadequate oxygen delivery, estimated from decreased oxygen delivery and increased oxygen extraction.	Oxygen	85-91	vasopressin	Sus scrofa	0-11
20690752-4	2010	Contrary to that, the methyl derivative L3(Me2) is transformed into the ortho-benzoquinone species L5(Me2), which still contains one methoxy substituent while one oxygen atom has been newly introduced.	Oxygen	163-169	malic enzyme 2	Homo sapiens	43-46
20832699-1	2010	OBJECTIVE: The aim of this study was to investigate the associations between alleles of the hypoxia-inducible factor 1A (HIF1A) C1772T polymorphism and several physiological responses to hypoxia, including the hypoxic ventilatory response (HVR), and serum erythropoietin (EPO), arterial oxygen saturation (Sao2), and acute mountain sickness (AMS) responses during 8 hours of exposure to normobaric hypoxia.	Oxygen	287-293	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-119
20832699-1	2010	OBJECTIVE: The aim of this study was to investigate the associations between alleles of the hypoxia-inducible factor 1A (HIF1A) C1772T polymorphism and several physiological responses to hypoxia, including the hypoxic ventilatory response (HVR), and serum erythropoietin (EPO), arterial oxygen saturation (Sao2), and acute mountain sickness (AMS) responses during 8 hours of exposure to normobaric hypoxia.	Oxygen	287-293	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-126
20832702-5	2010	RESULTS: The mean oxygen flow was 1.75 +- 1.58 L x min(-1) (mean +- SD) with a total yield of 40.4 +- 2.6 L. Oxygen flow increased slowly and with substantial variability between reactant groups, exceeding 2.0 L x min(-1) after 15.7 +- 6.4 minutes of operation.	Oxygen	18-24	CD59 molecule (CD59 blood group)	Homo sapiens	51-57
20832702-5	2010	RESULTS: The mean oxygen flow was 1.75 +- 1.58 L x min(-1) (mean +- SD) with a total yield of 40.4 +- 2.6 L. Oxygen flow increased slowly and with substantial variability between reactant groups, exceeding 2.0 L x min(-1) after 15.7 +- 6.4 minutes of operation.	Oxygen	109-115	CD59 molecule (CD59 blood group)	Homo sapiens	51-57
20832702-5	2010	RESULTS: The mean oxygen flow was 1.75 +- 1.58 L x min(-1) (mean +- SD) with a total yield of 40.4 +- 2.6 L. Oxygen flow increased slowly and with substantial variability between reactant groups, exceeding 2.0 L x min(-1) after 15.7 +- 6.4 minutes of operation.	Oxygen	109-115	CD59 molecule (CD59 blood group)	Homo sapiens	214-220
20832702-6	2010	Oxygen flow briefly peaked at 5.93 +- 0.56 L x min(-1) at 17.8 +- 7.9 minutes before rapidly falling to zero.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
20811646-1	2010	BACKGROUND: The Hypoxia Inducible Factor (HIF) mediates cellular adaptations to low oxygen.	Oxygen	84-90	similar	Drosophila melanogaster	16-40
20811646-1	2010	BACKGROUND: The Hypoxia Inducible Factor (HIF) mediates cellular adaptations to low oxygen.	Oxygen	84-90	similar	Drosophila melanogaster	42-45
20811646-2	2010	Prolyl-4-hydroxylases are oxygen sensors that hydroxylate the HIF alpha-subunit, promoting its proteasomal degradation in normoxia.	Oxygen	26-32	similar	Drosophila melanogaster	62-65
20811646-5	2010	PHD2 and PHD3 genes are induced in hypoxia to shut down HIF dependent transcription upon reoxygenation, while expression of PHD1 is oxygen-independent.	Oxygen	91-97	HIF prolyl hydroxylase	Drosophila melanogaster	0-4
20811646-5	2010	PHD2 and PHD3 genes are induced in hypoxia to shut down HIF dependent transcription upon reoxygenation, while expression of PHD1 is oxygen-independent.	Oxygen	91-97	similar	Drosophila melanogaster	56-59
20865124-4	2010	First, EGL-9 is the enzyme that targets HIF-1 for oxygen-dependent degradation via the VHL-1 E3 ligase.	Oxygen	50-56	Hypoxia-inducible factor 1	Caenorhabditis elegans	40-45
20669954-1	2010	Nitric oxide synthase (NOS), a homodimeric enzyme with a flavin reductase domain and a P450-type heme-containing oxygenase domain, catalyzes the formation of NO from L-arginine, NADPH, and O(2) in a two-step reaction sequence.	Oxygen	189-193	nitric oxide synthase 2	Homo sapiens	0-21
20413632-3	2010	OBJECTIVES: We hypothesized that ET1 levels in the first month would be higher in infants with CDH who subsequently expired or were discharged on oxygen (poor outcome).	Oxygen	146-152	endothelin 1	Homo sapiens	33-36
20690752-4	2010	Contrary to that, the methyl derivative L3(Me2) is transformed into the ortho-benzoquinone species L5(Me2), which still contains one methoxy substituent while one oxygen atom has been newly introduced.	Oxygen	163-169	malic enzyme 2	Homo sapiens	102-105
20675543-5	2010	These studies have indicated that activation of key transcription factors (MEF2, NFAT and Sp1) and co-activators (PGC-1alpha) by locomotor activity, differential intracellular calcium fluxes and low intracellular oxygen tension collectively regulate myoglobin expression.	Oxygen	213-219	PPARG coactivator 1 alpha	Homo sapiens	114-124
20559021-6	2010	Western blot analysis revealed that hypoxia (1% O2, 8 h) induced HIF-1alpha and HIF-2alpha expression in different gastric cancer cell lines, including SGC7901, AGS, MGC803 and MKN45.	Oxygen	48-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
20660313-2	2010	The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1alpha and HIF-2alpha are overexpressed in many human NSCLCs, and constitutive HIF-2alpha activity can promote murine lung tumor progression, suggesting that HIF proteins may be effective NSCLC therapeutic targets.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
20435418-1	2010	The degradation mechanism of p-nitrophenol (p-NP) exposed to 254 nm UV light was studied in the presence and the absence of oxygen respectively via both steady-state photolysis and time-resolved laser flash photolysis (LFP) experiments.	Oxygen	124-130	purine nucleoside phosphorylase	Homo sapiens	44-48
20435418-3	2010	In neutral solution p-NP(+) will be quickly deprotonated to form its phenoxyl radical (p-NP) which will react with oxygen to promote the breakage of benzene ring of p-NP.	Oxygen	115-121	purine nucleoside phosphorylase	Homo sapiens	20-24
20435418-3	2010	In neutral solution p-NP(+) will be quickly deprotonated to form its phenoxyl radical (p-NP) which will react with oxygen to promote the breakage of benzene ring of p-NP.	Oxygen	115-121	purine nucleoside phosphorylase	Homo sapiens	87-91
20435418-3	2010	In neutral solution p-NP(+) will be quickly deprotonated to form its phenoxyl radical (p-NP) which will react with oxygen to promote the breakage of benzene ring of p-NP.	Oxygen	115-121	purine nucleoside phosphorylase	Homo sapiens	87-91
20435418-5	2010	However, oxygen could improve the photo-degradation efficiency, which is due to the reaction of oxygen with p-NP.	Oxygen	9-15	purine nucleoside phosphorylase	Homo sapiens	108-112
20435418-5	2010	However, oxygen could improve the photo-degradation efficiency, which is due to the reaction of oxygen with p-NP.	Oxygen	96-102	purine nucleoside phosphorylase	Homo sapiens	108-112
20435418-6	2010	The reaction between oxygen and p-NP has been experimentally confirmed both in LFP and in pulse radiolysis.	Oxygen	21-27	purine nucleoside phosphorylase	Homo sapiens	32-36
20502970-1	2010	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20613473-8	2010	Tumor necrosis factor-alpha concentrations were significantly lower for samples incubated at 80% O2 when compared with 21% O2 (P &lt; 0.05).	Oxygen	97-99	tumor necrosis factor	Homo sapiens	0-27
20502970-1	2010	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20525878-2	2010	Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1alpha protein, an oxygen-sensitive subunit of HIF-1 that is a master factor for cellular response to hypoxia, significantly increases galectin-1 expression in both messenger RNA and protein levels in all four colorectal cancer (CRC) cell lines tested.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-78
20470447-9	2010	The peak of oxygen uptake correlated with CD34 positive and CD133 positive/CD34 positive cells, r is equal to 0.458 and 0.456; p-value less than 0.05, while no correlations were found between parameters of weight, body composition, and respiratory quotient with progenitor cells.	Oxygen	12-18	CD34 molecule	Homo sapiens	42-46
20525878-2	2010	Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1alpha protein, an oxygen-sensitive subunit of HIF-1 that is a master factor for cellular response to hypoxia, significantly increases galectin-1 expression in both messenger RNA and protein levels in all four colorectal cancer (CRC) cell lines tested.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-124
20470447-9	2010	The peak of oxygen uptake correlated with CD34 positive and CD133 positive/CD34 positive cells, r is equal to 0.458 and 0.456; p-value less than 0.05, while no correlations were found between parameters of weight, body composition, and respiratory quotient with progenitor cells.	Oxygen	12-18	CD34 molecule	Homo sapiens	75-79
20544853-6	2010	In contrast, using a model of oxygen-induced ischemic retinopathy, we show that astrocyte-derived VEGF is essential for hypoxia-induced neovascularization.	Oxygen	30-36	vascular endothelial growth factor A	Homo sapiens	98-102
20560877-0	2010	Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation.	Oxygen	93-99	interleukin 1 beta	Homo sapiens	11-28
20434429-2	2010	This pseudo-catalase cycle involves several redox intermediates including Compounds I, II and III, hydrogen peroxide reduction and oxidation reactions as well as release of both dioxygen and superoxide.	Oxygen	178-186	catalase	Homo sapiens	12-20
20494919-2	2010	Studies of the oxygen-sensitive subunit alpha of hypoxia-inducible factor-1 (HIF-1) are difficult owing to the large variety of functionally diverse muscle fibres that possess unique patterns of protein and gene expression, producing different capillarization and energy metabolism systems.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-75
20494919-2	2010	Studies of the oxygen-sensitive subunit alpha of hypoxia-inducible factor-1 (HIF-1) are difficult owing to the large variety of functionally diverse muscle fibres that possess unique patterns of protein and gene expression, producing different capillarization and energy metabolism systems.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-82
20471471-0	2010	Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species.	Oxygen	98-104	amyloid beta precursor protein	Homo sapiens	40-65
20522733-1	2010	Recombinant human erythropoietin (EPO) increases exercise capacity by stimulating erythropoiesis and subsequently enhancing oxygen delivery to the working muscles.	Oxygen	124-130	erythropoietin	Homo sapiens	18-32
20522733-1	2010	Recombinant human erythropoietin (EPO) increases exercise capacity by stimulating erythropoiesis and subsequently enhancing oxygen delivery to the working muscles.	Oxygen	124-130	erythropoietin	Homo sapiens	34-37
20522733-8	2010	We confirmed that 3 mo of administration of EPO increases exercise capacity, but the improvement could not be accounted for by other mechanisms than enhanced oxygen delivery.	Oxygen	158-164	erythropoietin	Homo sapiens	44-47
20522733-9	2010	In conclusion, EPO does not attenuate central fatigue or change cognitive performance strategy, suggesting that EPO enhances exercise capacity exclusively by increased oxygen delivery to the working muscles.	Oxygen	168-174	erythropoietin	Homo sapiens	112-115
20352475-11	2010	It could weaken the hydrophobic component of cyt c-CL interactions and might function following complex IV inhibition or in oxygen lack, both conditions producing accumulation of reduced cyt c and free fatty acids.	Oxygen	124-130	cytochrome c, somatic	Homo sapiens	187-192
20685321-5	2010	The basal mitochondrial oxygen consumption of CD4+PBLs from stavudine-treated patients was reduced relative to that of untreated HIV-infected patients and controls (stavudine treated group, 4.22 (25% 2.16, 75% 8.84); control uninfected, 11.2 (25% 3.95, 75% 16.6); untreated 18.1 (25% 11.8, 75% 37.9)ng oxygen atoms/min/ml).	Oxygen	24-30	CD4 molecule	Homo sapiens	46-49
20685321-5	2010	The basal mitochondrial oxygen consumption of CD4+PBLs from stavudine-treated patients was reduced relative to that of untreated HIV-infected patients and controls (stavudine treated group, 4.22 (25% 2.16, 75% 8.84); control uninfected, 11.2 (25% 3.95, 75% 16.6); untreated 18.1 (25% 11.8, 75% 37.9)ng oxygen atoms/min/ml).	Oxygen	302-308	CD4 molecule	Homo sapiens	46-49
20493790-5	2010	The balance between VO(2) and DO(2) is given by fractional oxygen extraction (FOE=VO(2)/DO(2)).	Oxygen	59-65	WAPL cohesin release factor	Homo sapiens	78-81
20716698-7	2010	Furthermore, we showed that S-nitrosoglutathione protects TGA1 from oxygen-mediated modifications and enhances the DNA binding activity of TGA1 to the as-1 element in the presence of NPR1.	Oxygen	68-74	bZIP transcription factor family protein	Arabidopsis thaliana	58-62
20079867-5	2010	In addition to the capacity of these proteins to promote fusion, mitofusin 2 or OPA1 regulate mitochondrial metabolism and loss-of-function reduces oxygen consumption and the capacity to oxidize substrates.	Oxygen	148-154	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	80-84
20679826-0	2010	Hyperbaric oxygen inhibits ischemia-reperfusion-induced neutrophil CD18 polarization by a nitric oxide mechanism.	Oxygen	11-17	integrin subunit beta 2	Rattus norvegicus	67-71
20679826-1	2010	BACKGROUND: Hyperbaric oxygen decreases ischemia-reperfusion-induced neutrophil/intercellular adhesion molecule-1 adhesion by blocking CD18 polarization.	Oxygen	23-29	integrin subunit beta 2	Rattus norvegicus	135-139
20679826-11	2010	RESULTS: C-PTIO-treated ischemia-reperfusion/hyperbaric oxygen plasma showed a significant increase in the percentage polarization of CD18 compared with ischemia-reperfusion/hyperbaric oxygen-untreated plasma from 4.1 + or - 2.5 percent to 33.7 + or - 7.7 percent (p &lt; or = 0.05).	Oxygen	56-62	integrin subunit beta 2	Rattus norvegicus	134-138
20679826-13	2010	Administration of N-nitro-L-arginine methyl ester and other nitric oxide synthase inhibitors before hyperbaric oxygen treatment restored neutrophil adhesion and CD18 polarization to ischemia-reperfusion control values, significantly greater than ischemia-reperfusion/hyperbaric oxygen alone.	Oxygen	111-117	integrin subunit beta 2	Rattus norvegicus	161-165
20679826-14	2010	CONCLUSION: These results suggest that the hyperbaric oxygen reduction of ischemia-reperfusion-induced neutrophil polarization of CD18 and adherence to intercellular adhesion molecule-1 is mediated through a nitric oxide mechanism that requires nitric oxide synthase.	Oxygen	54-60	integrin subunit beta 2	Rattus norvegicus	130-134
20665378-3	2010	Many of the effects of hypoxia are mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen-sensitive transcription factor.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-78
20665378-3	2010	Many of the effects of hypoxia are mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen-sensitive transcription factor.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
20493790-7	2010	Measurements of FOE for the whole body produce a range of about 0.15-0.33, i.e. the body consumes 15-33% of oxygen transported.	Oxygen	108-114	WAPL cohesin release factor	Homo sapiens	16-19
20583766-2	2010	An enzymatic oxygen scavenging system of glucose oxidase and catalase is widely used to improve the dye photostability but with the unfavorable side effect of producing gluconic acid.	Oxygen	13-19	catalase	Homo sapiens	61-69
20668552-7	2010	The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein.	Oxygen	62-68	BCL2 apoptosis regulator	Homo sapiens	4-9
20668552-7	2010	The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
20668552-7	2010	The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
20668552-7	2010	The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
20558139-6	2010	Treatment of Huh7 cells with kaempferol under hypoxic conditions (1% oxygen) effectively inhibited HIF-1 activity in a dose-dependent manner (IC(50)=5.16microM).	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
20723316-5	2010	The results indicated that the oxygen environment below normal oxygen, especially hypoxia, could amplify more primitive CD34(+)AC133(+) HSCs and CD34(+) HSCs with activity, arrest more HSCs in G0/G1 phase, promote the generation of BFU-E, CFU-GM, CFU-GEMM, and better preserve the migration ability of HSCs.	Oxygen	31-37	CD34 molecule	Homo sapiens	120-124
20723316-5	2010	The results indicated that the oxygen environment below normal oxygen, especially hypoxia, could amplify more primitive CD34(+)AC133(+) HSCs and CD34(+) HSCs with activity, arrest more HSCs in G0/G1 phase, promote the generation of BFU-E, CFU-GM, CFU-GEMM, and better preserve the migration ability of HSCs.	Oxygen	31-37	CD34 molecule	Homo sapiens	145-149
20723316-5	2010	The results indicated that the oxygen environment below normal oxygen, especially hypoxia, could amplify more primitive CD34(+)AC133(+) HSCs and CD34(+) HSCs with activity, arrest more HSCs in G0/G1 phase, promote the generation of BFU-E, CFU-GM, CFU-GEMM, and better preserve the migration ability of HSCs.	Oxygen	63-69	CD34 molecule	Homo sapiens	120-124
20723316-5	2010	The results indicated that the oxygen environment below normal oxygen, especially hypoxia, could amplify more primitive CD34(+)AC133(+) HSCs and CD34(+) HSCs with activity, arrest more HSCs in G0/G1 phase, promote the generation of BFU-E, CFU-GM, CFU-GEMM, and better preserve the migration ability of HSCs.	Oxygen	63-69	CD34 molecule	Homo sapiens	145-149
20979864-7	2010	RESULTS: In three non-oxygen subgroups, the serum VEGF was declining with postnatal age in prematurities and stable in term neonates.	Oxygen	22-28	vascular endothelial growth factor A	Homo sapiens	50-54
20979864-9	2010	Serum VEGF (ng/L) in oxygen subgroup at Weeks 1 and 3 was significantly lower than that of non-oxygen subgroup (324 +- 148 vs 522 +- 224, P = 0.000; 264 +- 106 vs 393 +- 220, P = 0.005) only in 32 - 36 week premature group.	Oxygen	21-27	vascular endothelial growth factor A	Homo sapiens	6-10
20624301-1	2010	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
20644645-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: Using patient skin biopsies, cell culture and murine infection models, HIF-1 activation was determined by immunohistochemistry, immunoblotting and reporter gene assays and was linked to cellular oxygen consumption.	Oxygen	227-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-108
20644645-6	2010	HIF-1 activation by human pathogens was induced by oxygen-dependent mechanisms.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
20624301-1	2010	BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
20513808-2	2010	The NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular metabolism in lipid synthesis, cellular defense against oxidative stress, oxidative respiration, and oxygen-sensing signal transduction.	Oxygen	210-216	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	66-70
20527796-2	2010	This CcO mimic not only performs the selective four-electron reduction of oxygen to water but also catalytically reduces oxygen using the biological one-electron reductant, cytochrome c.	Oxygen	74-80	cytochrome c, somatic	Homo sapiens	173-185
20527796-2	2010	This CcO mimic not only performs the selective four-electron reduction of oxygen to water but also catalytically reduces oxygen using the biological one-electron reductant, cytochrome c.	Oxygen	121-127	cytochrome c, somatic	Homo sapiens	173-185
20559130-6	2010	Even if the islet survives in a low-oxygen environment, the insulin productivity will likely be reduced.	Oxygen	36-42	insulin	Homo sapiens	60-67
20404338-8	2010	Depletion of PHD2 resulted in greater HIF-2alpha levels and therefore enhanced SOX9-induced cartilage matrix production compared with the levels normally found in hypoxia (1% oxygen) implying that PHD2 inhibition offers a novel means to enhance cartilage repair in vivo.	Oxygen	175-181	egl-9 family hypoxia inducible factor 1	Homo sapiens	13-17
20452975-9	2010	Furthermore, Pemt(+/+) mice that were fed a choline-deficient diet had increased oxygen consumption, had improved glucose tolerance, and gained less weight.	Oxygen	81-87	phosphatidylethanolamine N-methyltransferase	Mus musculus	13-17
20444740-2	2010	Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia.	Oxygen	45-51	erythropoietin	Homo sapiens	111-125
20444740-2	2010	Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia.	Oxygen	45-51	erythropoietin	Homo sapiens	127-130
20444740-2	2010	Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia.	Oxygen	45-51	erythropoietin	Homo sapiens	277-280
20408818-5	2010	Both selenite and GS-Se-SG were reduced by Grx1 and Grx2 in a non-stoichiometric manner due to redox cycling with oxygen, which in turn generated ROS.	Oxygen	114-120	glutaredoxin 2	Homo sapiens	52-56
20395290-6	2010	Our results position hypoxia-inducible factor-2alpha as a novel regulator of EGFR activation under low oxygen conditions, and suggest that hypoxia-induced EGFR signaling may promote a more aggressive phenotype in a fraction of HNSCC tumors.	Oxygen	103-109	epidermal growth factor receptor	Homo sapiens	77-81
20386489-5	2010	Low-VT ventilation with 50% oxygen significantly increased IL-6 and CXCL-2 expression versus low-VT ventilation alone.	Oxygen	28-34	interleukin 6	Rattus norvegicus	59-63
20583310-9	2010	The increased oxygen consumption by diabetic proximal tubular cells correlated with increased protein expressions of p47(phox) and nNOS and the treatments prevented these increases.	Oxygen	14-20	NSFL1 cofactor	Rattus norvegicus	117-120
20380593-1	2010	HIF-1alpha represents the oxygen-regulated sub-unit of the transcription factor HIF-1, which regulates the transcription of numerous genes involved in cellular response to hypoxia and oxidative stress.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20380593-1	2010	HIF-1alpha represents the oxygen-regulated sub-unit of the transcription factor HIF-1, which regulates the transcription of numerous genes involved in cellular response to hypoxia and oxidative stress.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
20436356-10	2010	Peak oxygen uptake increased from pre-LVAD measures of 11.8 mL x kg(-1) x min(-1) to 17.0 mL x kg(-1) x min(-1).	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	74-80
20436356-10	2010	Peak oxygen uptake increased from pre-LVAD measures of 11.8 mL x kg(-1) x min(-1) to 17.0 mL x kg(-1) x min(-1).	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	104-110
20223891-3	2010	Development of all embryos from SOD1-deficient oocytes was arrested at the 2-cell stage under conventional culture conditions with atmospheric oxygen (20% O(2)).	Oxygen	143-149	superoxide dismutase 1, soluble	Mus musculus	32-36
21787634-0	2010	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker.	Oxygen	61-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
21033220-2	2010	In oxygen deficiency Bcl-xL can also be upregulated.	Oxygen	3-9	BCL2 like 1	Homo sapiens	21-27
20386489-6	2010	LPS pretreatment combined with low-VT ventilation with 50% oxygen amplified IL-6 mRNA expression when compared with low VT alone or low VT + 50% O2 treatment.	Oxygen	59-65	interleukin 6	Rattus norvegicus	76-80
20461086-2	2010	Of the four identified PHD enzymes, PHD2 is considered to be the key oxygen sensor, as knockdown of PHD2 results in elevated HIF protein.	Oxygen	69-75	egl-9 family hypoxia inducible factor 1	Homo sapiens	36-40
20422640-5	2010	After adding exogenous cytochrome c, the sarcolemma isolated from myotubes had an ability to consume oxygen in the presence of NADH or succinate.	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	23-35
20619089-7	2010	RESULTS: Compared with the CBDL group, the alveoloarterial oxygen difference decreased significantly in CBDL+TNF-alpha mAb group.	Oxygen	59-65	tumor necrosis factor	Rattus norvegicus	109-118
20461086-2	2010	Of the four identified PHD enzymes, PHD2 is considered to be the key oxygen sensor, as knockdown of PHD2 results in elevated HIF protein.	Oxygen	69-75	egl-9 family hypoxia inducible factor 1	Homo sapiens	100-104
20206208-12	2010	We demonstrate that CD4(+) T cells are highly adaptive in bioenergetic terms which ensure their proper function under extreme conditions of glucose and/or oxygen availability as found under physiological and pathophysiological conditions.	Oxygen	155-161	CD4 molecule	Homo sapiens	20-23
20574527-4	2010	Under normoxic conditions, ET-1 controls HIF-alpha stability by inhibiting its degradation, as determined by impaired degradation of a reporter gene containing the HIF-1alpha oxygen-dependent degradation domain encompassing the PHD-targeted prolines.	Oxygen	175-181	endothelin 1	Homo sapiens	27-31
20574527-4	2010	Under normoxic conditions, ET-1 controls HIF-alpha stability by inhibiting its degradation, as determined by impaired degradation of a reporter gene containing the HIF-1alpha oxygen-dependent degradation domain encompassing the PHD-targeted prolines.	Oxygen	175-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-174
19827104-7	2010	Generally, Caco-2 cells preferred to attach on collagen-coated, fibronectin-coated, and fibronectin-coated oxygen-plasma treated PDMS.	Oxygen	107-113	fibronectin 1	Homo sapiens	88-99
20368331-2	2010	The HIF1alpha subunit is constantly synthesized and degraded under normoxia, but degradation is rapidly inhibited when oxygen levels drop.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-13
20368331-3	2010	Oxygen-dependent hydroxylation by prolyl-4-hydroxylases (PHD) mediates HIF1alpha proteasome degradation.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-80
20368331-6	2010	We assessed the separate involvement of oxygen and glucose in HIF1alpha regulation in differentiated neuroblastoma cells subjected to ischemia.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-71
20368331-7	2010	We report higher transcriptional activity and HIF1alpha expression under oxygen deprivation in the presence of glucose (OD), than in its absence (oxygen and glucose deprivation, OGD).	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-55
20368331-11	2010	Lack of HIF1alpha degradation in the presence of oxygen was accompanied by a very low alpha-ketoglutarate/fumarate ratio.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-17
20368331-13	2010	In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
20368331-13	2010	In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-244
20589171-6	2010	Indomethacin treatment in O2 resulted in higher pulmonary levels of 8-epi-PGF2alpha which was associated with downregulation of most antioxidant genes with early treatment and overexpression of GPX5 and 6 with late treatment.	Oxygen	26-28	glutathione peroxidase 5	Rattus norvegicus	194-198
20368331-13	2010	In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.	Oxygen	290-296	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
20368331-13	2010	In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.	Oxygen	290-296	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-244
20181925-8	2010	Accumulations of HIF-1alpha were detected in all four cell lines cultured in 1% O(2).	Oxygen	80-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
20384313-4	2010	The crystal structure (-173 degrees C) of fac-OsO(3)F(2)(NCCH(3)).2CH(3)CN consists of two co-crystallized CH(3)CN molecules and a pseudo-octahedral OsO(3)F(2).NCCH(3) molecule in which three oxygen atoms are in a facial arrangement and CH(3)CN is coordinated trans to an oxygen atom in an end-on fashion.	Oxygen	192-198	FA complementation group C	Homo sapiens	42-45
20384313-4	2010	The crystal structure (-173 degrees C) of fac-OsO(3)F(2)(NCCH(3)).2CH(3)CN consists of two co-crystallized CH(3)CN molecules and a pseudo-octahedral OsO(3)F(2).NCCH(3) molecule in which three oxygen atoms are in a facial arrangement and CH(3)CN is coordinated trans to an oxygen atom in an end-on fashion.	Oxygen	272-278	FA complementation group C	Homo sapiens	42-45
20207810-5	2010	In addition, we determined that insulin, at concentrations measured in humans and Zucker diabetic fatty rats with prediabetes, inhibited the O(2)-dependent release of ATP from rat red blood cells (RBCs).	Oxygen	141-145	insulin	Homo sapiens	32-39
20207810-8	2010	The finding that insulin attenuates the O(2)-dependent release of ATP from RBCs suggests that this defect in RBC physiology could contribute to a failure in the regulation of O(2) supply to meet the demand in skeletal muscle in prediabetes.	Oxygen	40-44	insulin	Homo sapiens	17-24
20231286-6	2010	Recently, an atypical sGC from Drosophila, Gyc-88E, was shown to form a stable complex with oxygen.	Oxygen	92-98	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	22-25
20398622-2	2010	It is embedded in the inner mitochondrial membrane where it couples the transfer of electrons from reduced cytochrome c to molecular oxygen with vectorial proton translocation across the membrane.	Oxygen	133-139	cytochrome c, somatic	Homo sapiens	107-119
20207810-8	2010	The finding that insulin attenuates the O(2)-dependent release of ATP from RBCs suggests that this defect in RBC physiology could contribute to a failure in the regulation of O(2) supply to meet the demand in skeletal muscle in prediabetes.	Oxygen	175-179	insulin	Homo sapiens	17-24
20153717-4	2010	Cells exposed to hypoxia respond acutely with endogenous metabolites and proteins promptly regulating metabolic pathways, but if low oxygen levels are prolonged, cells activate adapting mechanisms, the master switch being the hypoxia-inducible factor 1 (HIF-1).	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	226-252
20153717-4	2010	Cells exposed to hypoxia respond acutely with endogenous metabolites and proteins promptly regulating metabolic pathways, but if low oxygen levels are prolonged, cells activate adapting mechanisms, the master switch being the hypoxia-inducible factor 1 (HIF-1).	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	254-259
20188819-1	2010	The formation of reactive oxygen species by the cytochrome P450 monooxygenase system is thought to be due to autoxidation of NADPH-cytochrome P450 reductase and the nonproductive decay of oxygen-bound cytochrome P450 intermediates.	Oxygen	26-32	cytochrome p450 oxidoreductase	Homo sapiens	125-156
20503366-0	2010	Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy.	Oxygen	64-70	ephrin B2	Homo sapiens	31-39
20606811-6	2010	The formation of carbon-centered (1-hydroxyethyl) and oxygen-centered (hydroxyl) radicals during the metabolism of ethanol is considered: the generation of hydroxyethyl radicals, which occurs likely during the process of univalent reduction of dioxygen, is highlighted and is carried out by ferric cytochrome P(450) oxy-complex (P(450)-Fe(3+)O(2) (.-)) formed during the reduction of heme-oxygen.	Oxygen	54-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	298-315
20553503-7	2010	An internal disulfide bond may form which modifies the rate of dissociation of the distal histidine and apparently leads to different cytoglobin conformations, which may affect the observed oxygen affinity by an order of magnitude.	Oxygen	190-196	cytoglobin	Homo sapiens	134-144
20606811-6	2010	The formation of carbon-centered (1-hydroxyethyl) and oxygen-centered (hydroxyl) radicals during the metabolism of ethanol is considered: the generation of hydroxyethyl radicals, which occurs likely during the process of univalent reduction of dioxygen, is highlighted and is carried out by ferric cytochrome P(450) oxy-complex (P(450)-Fe(3+)O(2) (.-)) formed during the reduction of heme-oxygen.	Oxygen	244-252	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	298-315
20606811-6	2010	The formation of carbon-centered (1-hydroxyethyl) and oxygen-centered (hydroxyl) radicals during the metabolism of ethanol is considered: the generation of hydroxyethyl radicals, which occurs likely during the process of univalent reduction of dioxygen, is highlighted and is carried out by ferric cytochrome P(450) oxy-complex (P(450)-Fe(3+)O(2) (.-)) formed during the reduction of heme-oxygen.	Oxygen	246-252	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	298-315
20544535-3	2010	ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air.	Oxygen	51-57	apolipoprotein E	Mus musculus	0-4
20585293-8	2010	After the tenth week, we found a reduction of 11 beats.min-1 in average training heart rate, an increase of 0.5 mL/kg-1.min-1 in average training oxygen uptake and an increase of 8.6 Watts in average power output.	Oxygen	146-152	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
20551700-9	2010	Quantitative RT-PCR showed that the mRNA expression of VEGF-A, but not VEGFR-2 is upregulated in explants cultured at 1.5% compared with 21% oxygen.	Oxygen	141-147	vascular endothelial growth factor A	Homo sapiens	55-61
20107169-3	2010	In a model of oxygen-induced retinopathy (OIR), TNFalpha and iNOS, upregulated in response to tissue ischemia, are cytotoxic and inhibit vascular repair.	Oxygen	14-20	tumor necrosis factor	Mus musculus	48-56
20107169-3	2010	In a model of oxygen-induced retinopathy (OIR), TNFalpha and iNOS, upregulated in response to tissue ischemia, are cytotoxic and inhibit vascular repair.	Oxygen	14-20	nitric oxide synthase 2, inducible	Mus musculus	61-65
20299614-2	2010	HIF1A target genes code for proteins involved in oxygen transport, glycolytic enzymes, and glucose transporters.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
20066538-7	2010	The VEGF levels of IPF patients with high alveolar-arterial difference of oxygen (AaDO(2)) levels were significantly elevated than those with low AaDO(2) levels and those of healthy volunteers.	Oxygen	74-80	vascular endothelial growth factor A	Homo sapiens	4-8
20416277-2	2010	Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the hydroxylation of the specific proline and asparagine residues of HIF-1alpha, thereby controlling the level of HIF-1alpha and ultimately the HIF response.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
20416277-2	2010	Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the hydroxylation of the specific proline and asparagine residues of HIF-1alpha, thereby controlling the level of HIF-1alpha and ultimately the HIF response.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	226-236
20428565-1	2010	Catalase and methaemoglobin have very similar haem groups, which are both ferric, yet catalase decomposes hydrogen peroxide to water and oxygen very efficiently, while methaemoglobin does not.	Oxygen	137-143	catalase	Homo sapiens	0-8
20479825-2	2010	O(2)(a1Delta) is produced by a single rf-excited electric discharge sustained in an O(2)-He-NO gas mixture flowing through a rectangular geometry, and I(P2(1/2)) is then pumped using energy transferred from O(2)(a1Delta).	Oxygen	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-161
20372735-2	2010	The experimental data suggest that mefenamic acid acts as deprotonated monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
20428565-1	2010	Catalase and methaemoglobin have very similar haem groups, which are both ferric, yet catalase decomposes hydrogen peroxide to water and oxygen very efficiently, while methaemoglobin does not.	Oxygen	137-143	catalase	Homo sapiens	86-94
20386850-1	2010	2-(3-Benzyloxy)prop-1-ynyl)benzaldehyde with PtCl(2) in toluene would form Pt-pyryliums that underwent [3+2] cycloaddition with alkenes to the oxygen-bridged (5H-benzo[7]annulen-5-ylidene)platinum(ii) intermediates with good stereoselectivities.	Oxygen	143-149	PROP paired-like homeobox 1	Homo sapiens	15-21
20094799-6	2010	After MOMP was complete, the flux of cyt c diffusing back into the mitochondria was measured from the residual mitochondrial oxygen consumption after complete inhibition of the bc(1) with antimycin and myxothiazol.	Oxygen	125-131	cytochrome c, somatic	Homo sapiens	37-42
20388966-1	2010	Uncapped InN nanostructures undergo a deleterious natural aging process at ambient conditions by oxygen incorporation.	Oxygen	97-103	growth hormone releasing hormone	Homo sapiens	9-12
20459757-5	2010	Oxygen tension also affects many mammalian transactivators including AP-1, NFkB, and p53 by affecting the reduced state of critical cysteines in these proteins.	Oxygen	0-6	tumor protein p53	Homo sapiens	85-88
20459757-14	2010	CONCLUSIONS: We conclude that oxygen partial pressure and oxidative stress affects the functions of EBNA1 and Tat in a dramatically opposed fashion.	Oxygen	30-36	EBNA-1	Human gammaherpesvirus 4	100-105
20139176-1	2010	The transcription factor hypoxia-inducible factor (HIF)-1 plays a central physiological role in oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the subunit HIF-1alpha.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-57
20139176-1	2010	The transcription factor hypoxia-inducible factor (HIF)-1 plays a central physiological role in oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the subunit HIF-1alpha.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
20412331-7	2010	RESULTS: Exposure of Kupffer cells isolated from control mice to 1% oxygen activated hypoxia-inducible factor-1alpha, and increased mRNA levels of platelet-derived growth factor-B, vascular endothelial growth factor, angiopoietin-1 and monocyte chemotactic protein-1.	Oxygen	68-74	angiopoietin 1	Mus musculus	217-231
20302516-3	2010	NO donors can be useful to induce the transcription factor hypoxia-inducible factor 1 (HIF-1) that coordinates the protection of cells and tissues from the lack of oxygen, termed hypoxia.	Oxygen	164-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-85
20302516-3	2010	NO donors can be useful to induce the transcription factor hypoxia-inducible factor 1 (HIF-1) that coordinates the protection of cells and tissues from the lack of oxygen, termed hypoxia.	Oxygen	164-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
20672628-11	2010	When PP : MRP: MH = 100 (phr) : 15 (phr) : 50 (phr), the limited oxygen index of the MRP/MH/PP composite is 26%, and vertical firing ranks UL-94 V-0.	Oxygen	65-71	MYC binding protein 2	Homo sapiens	36-39
20672628-11	2010	When PP : MRP: MH = 100 (phr) : 15 (phr) : 50 (phr), the limited oxygen index of the MRP/MH/PP composite is 26%, and vertical firing ranks UL-94 V-0.	Oxygen	65-71	MYC binding protein 2	Homo sapiens	36-39
20427686-0	2010	Hyperbaric oxygen therapy for diabetic foot wounds: has hope hurdled hype?	Oxygen	11-17	FIC domain protein adenylyltransferase	Homo sapiens	69-73
20212266-13	2010	These results suggest that low tissue oxygen determines increased expression of the atrial SUR2A/B/Kir6.1 gene via activation of HIF-1alpha-FOXO1.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
20212266-13	2010	These results suggest that low tissue oxygen determines increased expression of the atrial SUR2A/B/Kir6.1 gene via activation of HIF-1alpha-FOXO1.	Oxygen	38-44	forkhead box O1	Homo sapiens	140-145
20359034-6	2010	The co-dehydrocoupling of 1 and 2 with AgNO3 even at dry nitrogen atmosphere is occurred, supporting that the oxidation of NO3- ion to NO2 is only the possible oxygen source, but not from the adventitious moisture in air.	Oxygen	160-166	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
20213746-7	2010	ASCs cultured in 1% oxygen secreted more vascular endothelial growth factor (VEGF) over the 4-week period than cells cultured in other conditions, with cells cultured in 2D secreting VEGF in a more sustained manner than those in 3D.	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	41-75
20213746-7	2010	ASCs cultured in 1% oxygen secreted more vascular endothelial growth factor (VEGF) over the 4-week period than cells cultured in other conditions, with cells cultured in 2D secreting VEGF in a more sustained manner than those in 3D.	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	77-81
20149461-7	2010	Two Ag1 atoms, related to each other by a symmetry centre, make bond contact with two equivalent oxygen atoms.	Oxygen	97-103	thioredoxin domain containing 12	Homo sapiens	4-7
20184893-1	2010	Cu,Zn superoxide dismutase (SOD1) is a dimeric metal-binding enzyme responsible for the dismutation of toxic superoxide to hydrogen peroxide and oxygen in cells.	Oxygen	145-151	superoxide dismutase 1	Homo sapiens	0-26
20158611-7	2010	RESULTS: Exposure of hepatocytes to 1% oxygen increased expression of alpha-smooth muscle actin, vimentin, Snail and fibroblast-specific protein-1 (FSP-1).	Oxygen	39-45	S100 calcium binding protein A4	Mus musculus	117-146
20158611-7	2010	RESULTS: Exposure of hepatocytes to 1% oxygen increased expression of alpha-smooth muscle actin, vimentin, Snail and fibroblast-specific protein-1 (FSP-1).	Oxygen	39-45	S100 calcium binding protein A4	Mus musculus	148-153
20213497-5	2010	Mechanisms involved include binding to repressor response elements on the eNOS gene, competing for co-regulators common to hormones with positive genomic actions, regulating eNOS co-factors, decreasing substrate for eNOS, and increasing production of oxygen-derived free radicals.	Oxygen	251-257	nitric oxide synthase 3	Homo sapiens	74-78
20836033-2	2010	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
20836033-2	2010	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20228054-3	2010	Here, we show that p53-dependent apoptosis in response to different DNA-damaging agents was reduced when normal and cancer cells were cultured at physiological oxygen tensions instead of the usual atmospheric levels.	Oxygen	160-166	tumor protein p53	Homo sapiens	19-22
20228054-5	2010	At these physiological oxygen levels, we found a constitutive activation of the ERK1/2 MAPK in all the models studied.	Oxygen	23-29	mitogen-activated protein kinase 3	Homo sapiens	80-86
20194505-4	2010	We reasoned that availability of molecular oxygen within the LOX active site favors oxygenation, whereas lack of O(2) promotes LTA epoxide synthesis.	Oxygen	43-49	seed linoleate 9S-lipoxygenase-3	Glycine max	61-64
20646612-21	2010	Compared with the severity of hypoxia, the insulin resistance has a closer relation with oxygen desaturation index.	Oxygen	89-95	insulin	Homo sapiens	43-50
20184893-1	2010	Cu,Zn superoxide dismutase (SOD1) is a dimeric metal-binding enzyme responsible for the dismutation of toxic superoxide to hydrogen peroxide and oxygen in cells.	Oxygen	145-151	superoxide dismutase 1	Homo sapiens	28-32
20156434-1	2010	Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1alpha and -2alpha).	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-160
22371751-7	2010	In the cyanotic group, oxygen saturation (SaO(2)) was negatively correlated with VEGF (r=-0.631, p &lt; 0.001) while haemoglobin was positively correlated (r=0.781, p = 0.007).	Oxygen	23-29	vascular endothelial growth factor A	Homo sapiens	81-85
20427666-3	2010	In addition to the well characterized oxygen-dependent mode of action of HIF-1, recent work has shown that various growth factors and cytokines stimulate HIF-1alpha expression, thereby triggering transcription of numerous hypoxia-inducible genes by oxygen-independent mechanisms.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-78
20427666-3	2010	In addition to the well characterized oxygen-dependent mode of action of HIF-1, recent work has shown that various growth factors and cytokines stimulate HIF-1alpha expression, thereby triggering transcription of numerous hypoxia-inducible genes by oxygen-independent mechanisms.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
20427666-3	2010	In addition to the well characterized oxygen-dependent mode of action of HIF-1, recent work has shown that various growth factors and cytokines stimulate HIF-1alpha expression, thereby triggering transcription of numerous hypoxia-inducible genes by oxygen-independent mechanisms.	Oxygen	249-255	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
20409470-8	2010	In Free AQP1, backbone oxygen atoms of Gly190, Cys191, and Gly192 lined, and were oriented to, the surface of the water pore channel.	Oxygen	23-29	aquaporin 1 (Colton blood group)	Homo sapiens	8-12
20184881-6	2010	Transfection of C(2)C(12) cells with a HIF-1alpha oxygen-dependent degradation domaine-GFP fusion protein revealed that prolyl hydroxylase (PHD) activity is impaired at low glucose concentrations, thus stabilizing the fusion protein.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
20416509-2	2010	A cell-based reporter produced by fusing HIF-1 alpha oxygen degradable domain (ODD) to luciferase was shown to work as a capture assay monitoring stability of the overexpressed luciferase-labeled HIF PHD substrate under conditions more physiological than in vitro test tubes.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-52
20307068-5	2010	In this report, the peroxide shunt with both Mn- and Fe-containing heme domain constructs of iNOS(heme) was used to characterize the formation of HNO as the initial inorganic product produced when oxygen activation occurs without pterin radical formation.	Oxygen	197-203	nitric oxide synthase 2	Homo sapiens	93-97
20589162-8	2010	VEGF, an oxygen-dependent gene, showed significant expression alterations across three time points in epithelium (p=0.008), but not in stroma (p=0.66).	Oxygen	9-15	vascular endothelial growth factor A	Homo sapiens	0-4
20145250-1	2010	Cellular oxygen sensing is required for hypoxia-inducible factor-1alpha stabilization, which is important for tumor cell survival, proliferation, and angiogenesis.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-71
20153226-7	2010	In addition, this study resulted in a k-nearest neighbour classification model with three descriptors suggesting the key role of oxygen (SssOE-index) and aromatic carbon (SaaCHE-index and SaasCE-index) atoms electro-topological environment that differentiate molecules binding to Akt1 kinase or PH domain.	Oxygen	129-135	AKT serine/threonine kinase 1	Homo sapiens	280-284
20308573-5	2010	Molecular oxygen is required for [PSI(+)] prion formation as growth under anaerobic conditions prevents prion formation in the tsa1 tsa2 mutant.	Oxygen	10-16	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	132-136
20361867-6	2010	Within the heme pocket the dioxygen molecule is stabilized by a hydrogen bonded network including TyrB10 and GlnE7.GLB-1 exhibits high ligand affinity, which is, however, lower than in other globins with the same distal TyrB10-GlnE7 amino-acid pair.	Oxygen	27-35	Globin-like protein	Caenorhabditis elegans	115-120
19948845-3	2010	For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-74
19948845-3	2010	For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-80
20022734-1	2010	Hypoxia (approximately 3-0.1% oxygen) is capable of rapidly inducing, via the hypoxia-inducible factor (HIF-1), a cell survival response engaging autophagy.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-109
20022734-4	2010	In contrast, severe hypoxic conditions or anoxia (&lt;0.1% oxygen), where the latter is often confused with physiological hypoxia, are capable of inducing a HIF-independent autophagic response, generated via an extreme nutritional stress response implicating the AMPK-mTOR and unfolded protein response (UPR) pathways.	Oxygen	59-65	mechanistic target of rapamycin kinase	Homo sapiens	268-272
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	251-257	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	251-257	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
20185296-1	2010	The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension.	Oxygen	251-257	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
19959649-2	2010	In the mouse model of oxygen-induced retinopathy (OIR), somatostatin-14 (SRIF) acting at the SRIF receptor subtype 2 (sst(2)) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor.	Oxygen	22-28	somatostatin	Mus musculus	73-77
19959649-2	2010	In the mouse model of oxygen-induced retinopathy (OIR), somatostatin-14 (SRIF) acting at the SRIF receptor subtype 2 (sst(2)) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor.	Oxygen	22-28	somatostatin	Mus musculus	93-97
19997118-4	2010	Exposing mice to normobaric hypoxia (8% oxygen for 48 h) led to a significant increase in vascular permeability associated with diminished expression of the TJ protein occludin.	Oxygen	40-46	occludin	Mus musculus	168-176
19813243-7	2010	Extracellular pH proved to more potently influence cell function than oxygen tension, the latter showing down-regulation of COL1 gene expression and up-regulation of VEGF protein under hypoxia.	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	166-170
20201565-3	2010	The relative propensities of amine donors versus carboxylate oxygen donors of four L = polyaminocarboxylate ligands to coordinate in fac-[Re(I)(CO)(3)L](n) complexes were assessed by examining the reaction of fac-[Re(I)(CO)(3)(H(2)O)(3)](+) under conditions differing in acidity and temperature.	Oxygen	61-67	FA complementation group C	Homo sapiens	133-136
19922526-5	2010	Furthermore, we analysed the expression of the ATF-4 target gene GADD153 as a function of oxygen concentration.	Oxygen	90-96	DNA damage inducible transcript 3	Homo sapiens	65-72
19922526-10	2010	CONCLUSION: Our results demonstrate the involvement of oxygen-dependent proteasomal degradation of ATF-4 in the hypoxia-induced expression of GADD153.	Oxygen	55-61	DNA damage inducible transcript 3	Homo sapiens	142-149
20530420-3	2010	RESULTS: There was a significant, and rather unexpected, association of HIF1alpha expression with high body mass index (BMI) (p=0.01) and high body weight (p=0.01) of patients with lung carcinomas, but other anesthesia-related parameters, including analysis of arterial oxygen partial tension and anthropometric factors remained insignificant.	Oxygen	270-276	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-81
19713194-5	2010	METHODS: C57BL/6J mice were exposed to 75% oxygen from postnatal day (p) 7 to p12.	Oxygen	43-49	polymerase (DNA-directed), delta 4	Mus musculus	78-81
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Oxygen	338-345	parathyroid hormone 1 receptor	Homo sapiens	22-26
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Oxygen	338-345	parathyroid hormone 1 receptor	Homo sapiens	153-157
20026114-8	2010	In CMA whole-blood measurements, splanchnic oxygen consumption (44.8 +/- 4.3 mL/min/1.73 m(2) BS) was slightly lower than in controls (57.5 +/- 8.4 mL/min/1.73 m(2) BS; P = NS).	Oxygen	44-50	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
20300020-8	2010	Excess postexercise oxygen consumption was significantly greater after SUPER (79.36 +/- 7.49 kJ) over TRAD (59.67 +/- 8.37 kJ).	Oxygen	20-26	RAD51 paralog D	Homo sapiens	102-106
20113439-9	2010	We found that the regulation of HRE1 and HRE2 by low oxygen relies on different mechanisms, since HRE1 requires protein synthesis to be induced while HRE2 does not.	Oxygen	53-59	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	32-36
20338478-1	2010	PURPOSE: Nitric oxide (NO), synthesized by the inducible nitric oxide synthase (iNOS), is known to inhibit metabolic oxygen consumption because of interference with mitochondrial respiratory activity.	Oxygen	117-123	nitric oxide synthase 2, inducible	Mus musculus	47-78
20338478-1	2010	PURPOSE: Nitric oxide (NO), synthesized by the inducible nitric oxide synthase (iNOS), is known to inhibit metabolic oxygen consumption because of interference with mitochondrial respiratory activity.	Oxygen	117-123	nitric oxide synthase 2, inducible	Mus musculus	80-84
20338478-6	2010	Activation of iNOS in tumor cells resulted in a profound oxygen sparing and a 2.3-fold radiosensitization.	Oxygen	57-63	nitric oxide synthase 2, inducible	Mus musculus	14-18
20338478-10	2010	CONCLUSIONS: Our study is the first, as far as we are aware, to provide evidence that iNOS may induce radiosensitization through oxygen sparing, and illuminates NO-producing macrophages as a novel determinant of tumor cell radioresponse within the hypoxic tumor microenvironment.	Oxygen	129-135	nitric oxide synthase 2, inducible	Mus musculus	86-90
20113439-9	2010	We found that the regulation of HRE1 and HRE2 by low oxygen relies on different mechanisms, since HRE1 requires protein synthesis to be induced while HRE2 does not.	Oxygen	53-59	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	98-102
20113439-11	2010	We propose that HRE1 and HRE2 play a partially redundant role in low oxygen signalling in Arabidopsis thaliana, thus improving the tolerance of the plant to the stress by enhancing anaerobic gene expression and ethanolic fermentation.	Oxygen	69-75	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	16-20
20152804-7	2010	The CO-enhanced Akt phosphorylation was suppressed by an O2(-) scavenger (Tiron), catalase or a superoxide dismutase (SOD) inhibitor (DETC).	Oxygen	57-59	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
20430163-1	2010	This study sought to determine whether oxygen radical scavengers of dimethylthiourea (DMTU), superoxide dismutase (SOD), or catalase (CAT) pretreatment attenuated ischemia-reperfusion (I/R)-induced lung injury.	Oxygen	39-45	catalase	Rattus norvegicus	134-137
20135683-4	2010	Significantly, low O(2) levels promote vascular development and maturation in wild-type (WT) ESC cultures measured by an increase in the numbers of CD31(+) endothelial cells (ECs) and sprouting angiogenic EBs, but refractory in Arnt(-/-) and Vegf(-/-) ESC cultures.	Oxygen	19-23	vascular endothelial growth factor A	Homo sapiens	242-246
20035031-11	2010	Additional beta(2)-adrenoceptor blockade with propranolol further inhibited myocardial oxygen supply during exercise, resulting in a further clockwise rotation of the relationship between myocardial oxygen consumption and coronary venous Po(2).	Oxygen	87-93	adrenoceptor beta 2	Sus scrofa	11-31
20205712-3	2010	The abundance and activity of HIF-1 are controlled through posttranslational modification by hydroxylases, the cellular oxygen sensors, of which the activity is oxygen dependent.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35
20205712-3	2010	The abundance and activity of HIF-1 are controlled through posttranslational modification by hydroxylases, the cellular oxygen sensors, of which the activity is oxygen dependent.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35
20205712-8	2010	Interaction between the O2-sensing hydroxylase PHD1 and HIF-1alpha was demonstrated and revealed exclusive localization of O2-sensing in the nucleus.	Oxygen	24-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
20205712-10	2010	CONCLUSION: FRET measurements do not only allow following the assembly of the HIF-1 complex under hypoxic conditions but can also provide important information about the process of O2-sensing and its localisation within a cell.MCS codes: 92C30, 92C05, 92C40.	Oxygen	181-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-83
20233687-5	2010	Results indicated competition exercise performance was significantly increased 4.2% (+49 sec; p&lt;0.05) as was peak VO2 response 4.4% (+2.5 ml O2 x kg(-1) x min(-1); p&lt;0.05) versus non-competition.	Oxygen	118-120	CD59 molecule (CD59 blood group)	Homo sapiens	158-164
20035031-11	2010	Additional beta(2)-adrenoceptor blockade with propranolol further inhibited myocardial oxygen supply during exercise, resulting in a further clockwise rotation of the relationship between myocardial oxygen consumption and coronary venous Po(2).	Oxygen	199-205	adrenoceptor beta 2	Sus scrofa	11-31
19901273-2	2010	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is a transcription factor that is the master regulator of cellular adaptation to low oxygen tension.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
19861159-4	2010	By hydroxylating HIF-1alpha in an oxygen-dependent manner PHDs and FIH-1 function as oxygen-sensing enzymes of HIF signalling.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
19861159-4	2010	By hydroxylating HIF-1alpha in an oxygen-dependent manner PHDs and FIH-1 function as oxygen-sensing enzymes of HIF signalling.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
19861159-5	2010	Besides molecular oxygen nitric oxide (NO), a mediator of the inflammatory response, can regulate HIF-1alpha accumulation, HIF-1 activity and HIF-1 dependent target gene expression.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
19861159-5	2010	Besides molecular oxygen nitric oxide (NO), a mediator of the inflammatory response, can regulate HIF-1alpha accumulation, HIF-1 activity and HIF-1 dependent target gene expression.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-103
19861159-5	2010	Besides molecular oxygen nitric oxide (NO), a mediator of the inflammatory response, can regulate HIF-1alpha accumulation, HIF-1 activity and HIF-1 dependent target gene expression.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-128
19861159-9	2010	More recent studies support the view that NO regulates HIF-1 by modulating the activity of the oxygen-sensor enzymes PHDs and FIH-1.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-60
19861159-12	2010	Three major mechanisms are discussed to be involved in enhancing the PHD activity despite the lack of oxygen: (1) NO mediated induction of a HIF-1 dependent feedback loop leading to newly expressed PHD2 and enhanced nuclear localization, (2) O2-redistribution towards PHDs after inhibition of mitochondrial respiration by NO, (3) reactivation of PHD activity by a NO mediated increase of iron and 2-oxoglutarate and/or involvement of reactive oxygen and/or nitrogen species.	Oxygen	242-244	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-146
19608588-5	2010	Concentrations of TNF-alpha were associated with the presence of bacteraemia, initial blood pressure &lt;90 mmHg and with a lower oxygen saturation at admission.	Oxygen	130-136	tumor necrosis factor	Homo sapiens	18-27
19901273-2	2010	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is a transcription factor that is the master regulator of cellular adaptation to low oxygen tension.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
19901273-3	2010	Only in hypoxic conditions is HIF-1alpha protein stabilized and translocated to the nucleus, where it induces transcription of target genes involved in oxygen delivery and energy metabolism.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
19861346-4	2010	Since angiotensin II is a pro-inflammatory compound that can induce the production of reactive oxygen species due to activation of the NADPH-dependent oxidase complex, this peptide might contribute to dopaminergic cell death.	Oxygen	95-101	angiotensinogen	Homo sapiens	6-20
19536046-2	2010	These investigations test the hypothesis that HO-1 overexpression protects against hemorrhage-induced hypoxia by regulating cellular respiration and oxygen availability.	Oxygen	149-155	heme oxygenase 1	Mus musculus	46-50
20518291-8	2010	However, serum adiponectin level was positively correlated with the minimum oxygen saturation.	Oxygen	76-82	adiponectin, C1Q and collagen domain containing	Homo sapiens	15-26
20518291-11	2010	And fasting adiponectin level was correlated with BMI, AHI and the minimum oxygen saturation.	Oxygen	75-81	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
19536046-7	2010	In vitro, HO-1 overexpression resulted in decreased cellular respiration under hypoxic conditions as determined by oxygen consumption and cytochrome c oxidase activity.	Oxygen	115-121	heme oxygenase 1	Mus musculus	10-14
19917279-0	2010	Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: application of an enzyme based oxygen deficiency system.	Oxygen	135-141	catalase	Homo sapiens	85-93
21789879-7	2010	The incidences of adverse reactions (respiratory rate &gt; or =35 breaths/min or oxygen saturation &lt; or =89% for &gt; or =1 min) were relatively high for the 21% O2-0 and 5 cm H2O CPAP groups (20 patients each) and low for the 40% O(2)-5 cmH2O CPAP group (2 patients).	Oxygen	165-167	troponin T2, cardiac type	Homo sapiens	241-245
20047324-10	2010	Higher concentrations of 1-hydroxyethyl radicals, which were trapped by N-tert-butyl-alpha-phenylnitrone (PBN) and detected by electron paramagnetic resonance spectroscopy, were observed when oxygen was excluded and when 4-MeC was included.	Oxygen	192-198	C-C motif chemokine ligand 28	Homo sapiens	223-226
20007914-7	2010	In LS heart tissues, lucigenin chemiluminescence was increased 2.3-fold to angiotensin II (10(-8) mol/L), and bradykinin (10(-4) mol/L) induced reduction of myocardial oxygen consumption in vitro was decreased (40 + or - 1.3% to 16 + or - 6.3%) and completely restored by coincubation with tiron, tempol or apocynin.	Oxygen	168-174	kininogen 1	Homo sapiens	110-120
19932078-9	2010	In contrast to the inhibition of NO generation, ROS enhanced O2(.-) production from iNOS, while ONOO(-) had the opposite effect.	Oxygen	61-63	nitric oxide synthase 2	Homo sapiens	84-88
20018872-4	2010	Exposure to low oxygen tension or treatment with the hypoxia-mimetic dimethyloxalyl glycine (DMOG) stabilized HIF-1alpha and up-regulated CTGF in human umbilical vein endothelial cells and in a murine microvascular endothelial cell line.	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
19760108-7	2010	Higher concentrations of zinc results on a rapid dismutation of O2*- to oxygen and hydrogen peroxide, which in turn is used by myeloperoxidase to generate hypochlorous acid (HOCl).	Oxygen	64-66	myeloperoxidase	Homo sapiens	127-142
20049649-5	2010	Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3).	Oxygen	124-130	cathelicidin antimicrobial peptide	Homo sapiens	23-28
19946328-2	2010	O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).	Oxygen	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-242
19946328-2	2010	O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).	Oxygen	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	244-249
19946328-2	2010	O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-242
19946328-2	2010	O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	244-249
19760108-7	2010	Higher concentrations of zinc results on a rapid dismutation of O2*- to oxygen and hydrogen peroxide, which in turn is used by myeloperoxidase to generate hypochlorous acid (HOCl).	Oxygen	72-78	myeloperoxidase	Homo sapiens	127-142
20066008-5	2010	Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption.	Oxygen	88-94	activating transcription factor 4	Mus musculus	14-18
19639355-3	2010	Repeated fluctuations in oxygen increased retinal vascular endothelial growth factor (VEGF) even while peripheral avascular retina persisted and prior to the development of intravitreous neovascularization.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	50-84
19639355-3	2010	Repeated fluctuations in oxygen increased retinal vascular endothelial growth factor (VEGF) even while peripheral avascular retina persisted and prior to the development of intravitreous neovascularization.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	86-90
19639355-4	2010	Repeated fluctuations in oxygen increased VEGF(164) expression but not VEGF(120).	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	42-46
19882183-4	2010	The importance of oxygen-dependent vascular endothelial growth factor in the pathophysiology of both phases of OIR has long been recognized.	Oxygen	18-24	vascular endothelial growth factor A	Homo sapiens	35-69
19639355-8	2010	Supplemental oxygen reduced retinal VEGF concentration and exacerbated NADPH oxidase activation to contribute to intravitreous neovascularization through activation of the JAK/STAT pathway.	Oxygen	13-19	vascular endothelial growth factor A	Homo sapiens	36-40
19768540-6	2010	The consumption of oxygen induced by 250 microM SIN-1 was found to be decreased in the presence of EP (0.5-10 mM), indicating that EP might affect the auto-oxidation of SIN-1.	Oxygen	19-25	MAPK associated protein 1	Homo sapiens	48-53
20030379-1	2010	A single-chamber microbial electrolysis cell (MEC) that used a high density of nonmetal-catalyst carbon fibers as the anode achieved high volumetric current densities from 1470 +/- 60 to 1630 +/- 50 A/m(3) for a hydraulic retention time of 1.6-6.5 h. The high current density was driven by a large anode surface area and corresponded to a volumetric chemical oxygen demand (COD)-removal rate of 27-49 kg COD/m(3).d.	Oxygen	359-365	C-C motif chemokine ligand 28	Homo sapiens	46-49
19859910-2	2010	In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF-alpha, thereby suppressing PGC-1alpha, and hence affecting down stream molecules that regulate oxygen transport and muscle function.	Oxygen	208-214	tumor necrosis factor	Mus musculus	109-118
19927033-4	2010	RESULTS: Both analyses (cross-sectional data followed by longitudinal data) showed a significant decline in peak oxygen consumption with age (0.03 and 0.04 L x min(-1) x yr(-1)), which was related to an age-associated decline in HRmax (0.97 and 0.81 beats per year) and peak oxygen pulse (0.13 and 0.08 mL per beat per year).	Oxygen	113-119	CD59 molecule (CD59 blood group)	Homo sapiens	160-166
19919574-7	2010	Low oxygen conditions increase the Bcl-2 protein, which is associated with anti-apoptotic signals, and recover the PrP (106-126)-induced reduction in mitochondrial transmembrane potential.	Oxygen	4-10	prion protein	Homo sapiens	115-118
19768540-6	2010	The consumption of oxygen induced by 250 microM SIN-1 was found to be decreased in the presence of EP (0.5-10 mM), indicating that EP might affect the auto-oxidation of SIN-1.	Oxygen	19-25	MAPK associated protein 1	Homo sapiens	169-174
19880525-1	2010	Activation of transcription in response to low oxygen tension is mediated by the hypoxia-inducible factor-1 (HIF-1).	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-107
20041248-10	2010	CONCLUSIONS: Because VEGF probably functions as a hypoxia-inducible angiogenic factor, overexpression of this mediator, concomitant with hypervascularity, may be induced more strongly in malignant thyroid tumors, which need more oxygen to proliferate, than in benign follicular tumors.	Oxygen	229-235	vascular endothelial growth factor A	Homo sapiens	21-25
20066380-9	2010	The oxygen bridge between two Co(iii) sites in the Co(3)O(4) cluster is responsible for the oxidation reactions with CO, NO, C(2)H(2), and C(2)H(4).	Oxygen	4-10	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	30-37
20109207-5	2010	RESULTS: After transferring MSC from atmospheric oxygen levels of 21% to 1%, HIF-1alpha expression was induced, indicating efficient oxygen reduction.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
20109207-5	2010	RESULTS: After transferring MSC from atmospheric oxygen levels of 21% to 1%, HIF-1alpha expression was induced, indicating efficient oxygen reduction.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
19880525-1	2010	Activation of transcription in response to low oxygen tension is mediated by the hypoxia-inducible factor-1 (HIF-1).	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-114
19880525-9	2010	Chromatin immunoprecipitation demonstrated that at 1% O(2) CBP is recruited to a HIF-1 alpha but not to a p53 target gene.	Oxygen	54-58	CREB binding protein	Homo sapiens	59-62
19880525-9	2010	Chromatin immunoprecipitation demonstrated that at 1% O(2) CBP is recruited to a HIF-1 alpha but not to a p53 target gene.	Oxygen	54-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-92
20193091-9	2010	In contrast, reducing O(2) during Phase II resulted in increased proteoglycan and type II collagen synthesis and reduced expression and release of MMP-13 mRNA and protein.	Oxygen	22-26	matrix metallopeptidase 13	Homo sapiens	147-153
20024146-9	2010	Control experiments showed that the photo-induced reduction of cytochrome c only occurs in the absence of oxygen and presence of a sacrificial donor.	Oxygen	106-112	cytochrome c, somatic	Homo sapiens	63-75
20204774-8	2010	These results suggest beneficial roles of PPARalpha activated by fenofibrate on the regulation of both lipid metabolisms and microvascular environments of oxygen metabolism in HFD-induced fatty liver.	Oxygen	155-161	peroxisome proliferator activated receptor alpha	Mus musculus	42-51
20338856-7	2010	Oxygen consumption in single smooth muscle cells A7r5 during an [Arg(8)]-vasopressin-induced contraction is measured.	Oxygen	0-6	arginine vasopressin	Homo sapiens	73-84
20037603-6	2010	CONCLUSION: Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA-dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level.	Oxygen	250-256	epidermal growth factor receptor	Homo sapiens	92-96
20037603-6	2010	CONCLUSION: Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA-dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level.	Oxygen	250-256	AKT serine/threonine kinase 1	Homo sapiens	115-118
20037603-6	2010	CONCLUSION: Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA-dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level.	Oxygen	250-256	mitogen-activated protein kinase 3	Homo sapiens	123-129
20037603-6	2010	CONCLUSION: Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA-dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level.	Oxygen	250-256	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-204
19875090-7	2010	The resultant elevated intraocular oxygen tension likely proves beneficial for vascular endothelial growth factor-mediated retinal diseases.	Oxygen	35-41	vascular endothelial growth factor A	Homo sapiens	79-113
20028863-6	2010	Gain and loss of function experiments defined PHD2 and PHD3 as HIF target genes that remained operative even at low oxygen concentrations.	Oxygen	116-122	egl-9 family hypoxia inducible factor 1	Homo sapiens	46-50
19995553-2	2010	The HIF1A gene product HIF-1alpha plays key roles in maintaining oxygen homeostasis in eukaryotic organisms and is involved in many processes, including immune response and hematopoiesis.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
19995553-2	2010	The HIF1A gene product HIF-1alpha plays key roles in maintaining oxygen homeostasis in eukaryotic organisms and is involved in many processes, including immune response and hematopoiesis.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
20460770-0	2010	Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells.	Oxygen	33-39	RB transcriptional corepressor like 2	Rattus norvegicus	81-86
19883626-4	2010	In this study, we show that expression of ephrinB2 is oxygen dependent.	Oxygen	54-60	ephrin B2	Homo sapiens	42-50
20054152-13	2010	ET-1 was oppositely regulated by decreased oxygen tensions in the investigated cell types.	Oxygen	43-49	endothelin 1	Homo sapiens	0-4
19690399-7	2010	Low oxygen tension has an inhibitory effect on MMP-13 and TIMP-1 expression, which are involved in extracellular matrix remodeling and potentially vascular invasion.	Oxygen	4-10	matrix metallopeptidase 13	Homo sapiens	47-53
19690399-7	2010	Low oxygen tension has an inhibitory effect on MMP-13 and TIMP-1 expression, which are involved in extracellular matrix remodeling and potentially vascular invasion.	Oxygen	4-10	TIMP metallopeptidase inhibitor 1	Homo sapiens	58-64
20018547-3	2010	The decrease of oxygen partial pressure, a reduced number of erythrocytes caused by bleeding or excessive destruction, or increased tissues oxygen requirements lead to increased secretion of EPO.	Oxygen	16-22	erythropoietin	Homo sapiens	191-194
20018547-3	2010	The decrease of oxygen partial pressure, a reduced number of erythrocytes caused by bleeding or excessive destruction, or increased tissues oxygen requirements lead to increased secretion of EPO.	Oxygen	140-146	erythropoietin	Homo sapiens	191-194
21787583-3	2010	Chromium diminished oxygen consumption by cells in a concentration-dependent manner (IC(50)=66+-8muM).	Oxygen	20-26	latexin	Homo sapiens	97-100
20517715-5	2010	In neutrophils, HIF-1alpha promotes survival under O(2)-deprived conditions and mediates blood vessel extravasation by modulating beta (2) integrin expression.	Oxygen	51-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
21190501-3	2010	Extensively reduced arterial oxygen saturation at rest (R-Spo2) has been proposed as an indicator of inadequate acclimatization and impending AMS.	Oxygen	29-35	R-spondin 2	Homo sapiens	56-62
20046003-4	2010	The arterial oxygen tension/inspiratory oxygen fraction ratio improved during PMX-DHP treatment in all 3 patients.	Oxygen	13-19	dihydropyrimidinase	Homo sapiens	82-85
20808661-4	2010	Thus there is an increase in pulmonary ventilation, increase in diffusing capacity in the lung, an increase in the cardiac output and increase in the red blood cell count due to an increase in erythropoietin secretion by the kidney, all of which enhance oxygen delivery to the cells.	Oxygen	254-260	erythropoietin	Homo sapiens	193-207
19924633-6	2010	These data support the existence, in the placenta, of metabolic reprogramming mechanisms, previously documented in tumor cells, whereby HIF-1 stimulates reductions in mitochondrial oxygen consumption at the cost of increased glucose consumption.	Oxygen	181-187	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-141
20647644-0	2010	Using the oxygen-cost diagram in ramp-slope selection for dyspneic patients.	Oxygen	10-16	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	33-37
20647644-3	2010	Oxygen-cost diagram (OCD) is a scoring scale for the capability of daily activity performed and therefore can be used to estimate the ramp-slope.	Oxygen	0-6	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	134-138
19737107-3	2010	In this study, we developed an adenoviral vector carrying a fusion of human WW domain-containing oxidoreductase (hWWOX) and the HIF-1alpha oxygen-dependent degradation domain (ODD) under the control of a synthetic human recombinant telomerase reverse transcriptase promoter (hrTRTP).	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
20046003-4	2010	The arterial oxygen tension/inspiratory oxygen fraction ratio improved during PMX-DHP treatment in all 3 patients.	Oxygen	40-46	dihydropyrimidinase	Homo sapiens	82-85
19801500-0	2010	Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC.	Oxygen	26-32	tumor necrosis factor	Homo sapiens	14-17
20397086-1	2010	A methodology is presented to determine the impact of flow rate upon sediment oxygen demand (SOD) based upon dissolved oxygen transport through the logarithmic boundary layer in stream systems.	Oxygen	78-84	superoxide dismutase 1	Homo sapiens	93-96
20397086-1	2010	A methodology is presented to determine the impact of flow rate upon sediment oxygen demand (SOD) based upon dissolved oxygen transport through the logarithmic boundary layer in stream systems.	Oxygen	119-125	superoxide dismutase 1	Homo sapiens	93-96
19845827-4	2010	It has been shown that HIF-1 triggers the expression of genes involved in oxygen transport, glycolytic metabolism, angiogenesis, cell survival, apoptosis, and others processes that can interfere with cell survival.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
20209309-4	2010	In addition, serum IL-6 concentrations presented a significant positive correlation with the duration of oxygen therapy and with the length of hospital stay.	Oxygen	105-111	interleukin 6	Homo sapiens	19-23
20209309-6	2010	The serum levels of IL-6 determined at admission could also be used to predict prolonged oxygen supplementation and hospital stay.	Oxygen	89-95	interleukin 6	Homo sapiens	20-24
19801500-4	2010	In this study, we demonstrate that inhibition of delta-PKC with a dominant-negative delta-PKC TAT peptide resulted in a significant delay in the onset time of TNF-elicited O(2)(-) generation but had no effect on Vmax, indicating an involvement of delta-PKC in the initiation of O(2)(-) production.	Oxygen	172-176	tumor necrosis factor	Homo sapiens	159-162
19801500-4	2010	In this study, we demonstrate that inhibition of delta-PKC with a dominant-negative delta-PKC TAT peptide resulted in a significant delay in the onset time of TNF-elicited O(2)(-) generation but had no effect on Vmax, indicating an involvement of delta-PKC in the initiation of O(2)(-) production.	Oxygen	278-282	tumor necrosis factor	Homo sapiens	159-162
19801500-5	2010	In contrast, fMLP-elicited O(2)(-) production in adherent and nonadherent neutrophils was delta-PKC-independent, suggesting differential regulation of O(2)(-) production.	Oxygen	27-31	formyl peptide receptor 1	Homo sapiens	13-17
19801500-5	2010	In contrast, fMLP-elicited O(2)(-) production in adherent and nonadherent neutrophils was delta-PKC-independent, suggesting differential regulation of O(2)(-) production.	Oxygen	151-155	formyl peptide receptor 1	Homo sapiens	13-17
19801500-7	2010	In adherent neutrophils, TNF triggered a time-dependent association of delta-PKC with p47phox, which was associated with p47phox phosphorylation, indicating a role for delta-PKC in regulating O(2)(-) production at the level of p47phox.	Oxygen	192-197	tumor necrosis factor	Homo sapiens	25-28
19766670-3	2010	The oxygen-dependent degradation (ODD) domain of HIF-1alpha can lead to degradation of the HIF-1alpha protein in normoxia.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
19755960-2	2010	The HIF-1alpha subunit, which is regulated by O2-dependent hydroxylation, ubiquitination, and degradation, has been identified as an important molecular target for cancer therapy.	Oxygen	46-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
19957135-3	2010	Hypoxia inducible factor 1 (HIF-1) is the key transcription factor in controlling the expression of oxygen-dependent genes required for this adaptation.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19957135-3	2010	Hypoxia inducible factor 1 (HIF-1) is the key transcription factor in controlling the expression of oxygen-dependent genes required for this adaptation.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19957135-4	2010	HIF-1 is a heterodimer of an oxygen dependent alpha-subunit and constitutive beta-subunit.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19889840-2	2010	The transcription factor hypoxia-inducible factor (HIF)-1 is well known to respond to alterations in oxygen availability.	Oxygen	101-107	Hypoxia-inducible factor 1	Caenorhabditis elegans	25-57
19956890-4	2010	Compared with those in normoxia (20% O2), Hpa mRNA, protein and enzymatic activity levels, were up-regulated by a reduction in the oxygen level (1% O2).	Oxygen	131-137	heparanase	Homo sapiens	42-45
19956890-4	2010	Compared with those in normoxia (20% O2), Hpa mRNA, protein and enzymatic activity levels, were up-regulated by a reduction in the oxygen level (1% O2).	Oxygen	148-150	heparanase	Homo sapiens	42-45
19766670-3	2010	The oxygen-dependent degradation (ODD) domain of HIF-1alpha can lead to degradation of the HIF-1alpha protein in normoxia.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
20418617-4	2010	Residual oxygen was rapidly consumed at a rate, r(O(2)), of 0.35 mg O(2) l(-1) min(-1).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	79-85
21113404-4	2010	Following eight days in culture at 1% oxygen, C(2)C(12) muscle myoblasts displayed a reduction of PGC-1alpha, PPAR-alpha, and RXR-alpha mRNA, as well as CPT-1b and UCP-2 mRNA.	Oxygen	38-44	PPARG coactivator 1 alpha	Homo sapiens	98-108
19755485-5	2010	HIF1A protein was not expressed at 20% oxygen and displayed only a transient, nuclear localisation at 5% oxygen.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19755485-5	2010	HIF1A protein was not expressed at 20% oxygen and displayed only a transient, nuclear localisation at 5% oxygen.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19755485-6	2010	HIF2A (EPAS1) and HIF3A displayed a cytoplasmic localisation during initial hypoxic culture but translocated to the nucleus following long-term culture at 5% oxygen and were significantly upregulated compared with cells cultured at 20% oxygen.	Oxygen	158-164	hypoxia inducible factor 3 subunit alpha	Homo sapiens	18-23
19755485-6	2010	HIF2A (EPAS1) and HIF3A displayed a cytoplasmic localisation during initial hypoxic culture but translocated to the nucleus following long-term culture at 5% oxygen and were significantly upregulated compared with cells cultured at 20% oxygen.	Oxygen	236-242	hypoxia inducible factor 3 subunit alpha	Homo sapiens	18-23
20062524-3	2010	We also show that the phagocytosis of yeast and the release of reactive oxygen intermediates in response to Candida albicans challenge are impaired in macrophages from Dectin-1 deficient mice treated with PPARgamma ligands or IL-13.	Oxygen	72-78	interleukin 13	Mus musculus	226-231
20297691-0	2010	[Erythropoietin influence on oxygen transport function of blood and prooxidant/antioxidant balance in rabbits under lipopolysaccharide injection].	Oxygen	29-35	erythropoietin	Oryctolagus cuniculus	1-15
20297691-1	2010	We aimed to study the erythropoietin influence on oxygen transport function of blood and prooxidant/antioxidant balance in rabbits under lipopolysaccharide injection.	Oxygen	50-56	erythropoietin	Oryctolagus cuniculus	22-36
20297691-4	2010	Erythropoietin improves parameters of oxygen transport function of blood, increases hemoglobin-oxygen affinity through the NO-dependent mechanism, reduces activity of free radical processes, and increases antioxidant protection under lipopolysaccharide injection.	Oxygen	38-44	erythropoietin	Oryctolagus cuniculus	0-14
20297691-4	2010	Erythropoietin improves parameters of oxygen transport function of blood, increases hemoglobin-oxygen affinity through the NO-dependent mechanism, reduces activity of free radical processes, and increases antioxidant protection under lipopolysaccharide injection.	Oxygen	95-101	erythropoietin	Oryctolagus cuniculus	0-14
19928890-8	2009	Moreover, a decrease of the spin population on all oxygen atoms as a result of complexation of Pb(II) via carboxyl oxygens and protonation of hydroxyl oxygens is required to reproduce the experimental g parameters.	Oxygen	51-57	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
20355325-5	2010	The activities of the oxygen-scavenging enzymes catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) in infected leaves were significantly higher than those in the healthy leaves, and the enzyme activities in DGIs were always lower than in the yellow leaf tissues.	Oxygen	22-28	catalase	Homo sapiens	58-61
20355325-5	2010	The activities of the oxygen-scavenging enzymes catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) in infected leaves were significantly higher than those in the healthy leaves, and the enzyme activities in DGIs were always lower than in the yellow leaf tissues.	Oxygen	22-28	superoxide dismutase 1	Homo sapiens	86-106
20355325-5	2010	The activities of the oxygen-scavenging enzymes catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) in infected leaves were significantly higher than those in the healthy leaves, and the enzyme activities in DGIs were always lower than in the yellow leaf tissues.	Oxygen	22-28	superoxide dismutase 1	Homo sapiens	108-111
19928890-8	2009	Moreover, a decrease of the spin population on all oxygen atoms as a result of complexation of Pb(II) via carboxyl oxygens and protonation of hydroxyl oxygens is required to reproduce the experimental g parameters.	Oxygen	115-122	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
19832698-4	2009	Mice with a hepatocellular-specific deficiency in the Pten (phosphatase and tensin homologue deleted on chromosome 10) gene, a tumour suppressor, were exposed to a 10% O2 (hypoxic) or 21% O2 (control) atmosphere for 7 days.	Oxygen	168-170	phosphatase and tensin homolog	Mus musculus	54-58
20023878-0	2009	Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution.	Oxygen	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
20975915-4	2009	The HIF-1 alpha is absolutely critical for continued survival of cancer cells as it is involved in the activation of glycolysis and it helps an oxygen-starved cell convert sugar to energy without using oxygen.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-15
19782121-1	2009	The oxidative injury in Alzheimer"s disease (AD), in which amyloid beta protein induces production of reactive oxygen species, may be cause of neurodegeneration.	Oxygen	111-117	amyloid beta precursor protein	Homo sapiens	59-71
20003191-1	2009	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
20003191-1	2009	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
19801639-10	2009	Oxygen tension, substrate, and pH levels were important regulators of AO-catalyzed NO generation.	Oxygen	0-6	aldehyde oxidase 1	Homo sapiens	70-72
20007376-3	2009	Herein, we describe experiments that imply that the phenomenon probably results from reversible inhibition of the enzyme cytochrome c oxidase (CcO), which reduces oxygen during respiration.	Oxygen	163-169	cytochrome c, somatic	Homo sapiens	121-133
19785994-5	2009	Moreover, the consumption of oxygen caused by 250 microM SIN-1 was found to be decreased in the presence of aspirin, indicating that aspirin might affect the auto-oxidation of SIN-1.	Oxygen	29-35	MAPK associated protein 1	Homo sapiens	57-62
19785994-5	2009	Moreover, the consumption of oxygen caused by 250 microM SIN-1 was found to be decreased in the presence of aspirin, indicating that aspirin might affect the auto-oxidation of SIN-1.	Oxygen	29-35	MAPK associated protein 1	Homo sapiens	176-181
20975915-4	2009	The HIF-1 alpha is absolutely critical for continued survival of cancer cells as it is involved in the activation of glycolysis and it helps an oxygen-starved cell convert sugar to energy without using oxygen.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-15
20054120-1	2009	Glycolate oxidase, a peroxisomal flavoenzyme, generates glyoxylate at the expense of oxygen.	Oxygen	85-91	hydroxyacid oxidase 2	Homo sapiens	0-17
19552994-14	2009	IL-6 levels at baseline correlated significantly and negatively with minimum nocturnal oxygen saturation.	Oxygen	87-93	interleukin 6	Homo sapiens	0-4
20078552-6	2009	For this, we have analyzed the coding region of oxygen-dependent degradation domain of HIF1alpha in 47 colon, 47 gastric, 47 breast, 47 lung, and 47 hepatocellular carcinomas, and 47 acute leukemias by a single-strand conformation polymorphism assay.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-96
19779343-5	2009	Many of the effects of low oxygen have been attributed to action by hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-99
19506990-13	2009	This MPO, which releases proteolytic enzymes and radical oxygen species, acts on tissue destruction, namely the lysis of endothelial cell membranes as well as vascular basement membranes in the peritubular capillary.	Oxygen	57-63	myeloperoxidase	Homo sapiens	5-8
19786866-11	2009	Thus, high aerobic power as assessed by maximal oxygen consumption appears to be associated with lower plasma viscosity and lower plasma fibrinogen.	Oxygen	48-54	fibrinogen beta chain	Homo sapiens	137-147
19779343-5	2009	Many of the effects of low oxygen have been attributed to action by hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
19819950-0	2009	Inhibition of oxygen-induced hypoxia-inducible factor-1alpha degradation unmasks estradiol induction of vascular endothelial growth factor expression in ECC-1 cancer cells in vitro.	Oxygen	14-20	vascular endothelial growth factor A	Homo sapiens	104-138
20091346-6	2009	The proportion of cells in the S (DNA synthesis) phase of the cell cycle was increased by 50%, and p21(Cip1) gene and protein expression was decreased in 5 versus 20% oxygen.	Oxygen	167-173	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-102
20091346-6	2009	The proportion of cells in the S (DNA synthesis) phase of the cell cycle was increased by 50%, and p21(Cip1) gene and protein expression was decreased in 5 versus 20% oxygen.	Oxygen	167-173	cyclin dependent kinase inhibitor 1A	Homo sapiens	103-107
19766100-1	2009	The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha).	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-56
19773738-7	2009	Compared with wild-type mice, the obese phenotype observed in the GAL-Tg mice was attributed to decreased oxygen consumption and carbon dioxide production, and this effect was independent of any changes in food intake or horizontal activity.	Oxygen	106-112	galanin and GMAP prepropeptide	Mus musculus	66-69
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	interferon gamma	Homo sapiens	74-90
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	beta-1,3-glucuronyltransferase 1	Homo sapiens	223-227
19558268-9	2009	Changes in adiponectin levels during nCPAP therapy were positively correlated with an improvement in minimum oxygen saturation (r = 0.773; P = 0.041) and negatively correlated with changes in TNF-alpha levels (r = -0.885; P = 0.008).	Oxygen	109-115	adiponectin, C1Q and collagen domain containing	Homo sapiens	11-22
19892399-4	2009	Hypoxia (3% O(2)) significantly promoted FGF2- and VEGF-stimulated cell proliferation as compared to normoxia.	Oxygen	12-16	fibroblast growth factor 2	Homo sapiens	41-45
19892399-4	2009	Hypoxia (3% O(2)) significantly promoted FGF2- and VEGF-stimulated cell proliferation as compared to normoxia.	Oxygen	12-16	vascular endothelial growth factor A	Homo sapiens	51-55
20596845-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) and the neo-angiogenic factors induced as a result of hypoxia-inducible factor transcriptional activation may contribute to tumorigenesis by inducing vessel formation that in turn provides oxygen and nutrients promoting tumor expansion.	Oxygen	234-240	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
20596845-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) and the neo-angiogenic factors induced as a result of hypoxia-inducible factor transcriptional activation may contribute to tumorigenesis by inducing vessel formation that in turn provides oxygen and nutrients promoting tumor expansion.	Oxygen	234-240	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19138863-7	2009	Vertical impulse over the extension phase was lower (p&lt;0.05) while backward horizontal impulse was higher (p&lt;0.05) during unloaded condition than those extrapolated to 0 W. Oxygen consumptions were higher during unloaded condition than extrapolated to 0 W (750+/-147 vs. 529+/-297 mLO(2) x min(-1); p&lt;0.05).	Oxygen	179-185	CD59 molecule (CD59 blood group)	Homo sapiens	296-302
19766100-1	2009	The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha).	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
19919690-2	2009	When oxygen tensions fall HIF-1alpha protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions.	Oxygen	5-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-36
19844232-7	2009	RESULTS: Exposure to 0.1% oxygen resulted in elevated levels of Snail protein, along with changes in vimentin and E-cadherin expression, and in addition increased migration of MDA-MB-468 cells.	Oxygen	26-32	snail family transcriptional repressor 1	Homo sapiens	64-69
19844232-7	2009	RESULTS: Exposure to 0.1% oxygen resulted in elevated levels of Snail protein, along with changes in vimentin and E-cadherin expression, and in addition increased migration of MDA-MB-468 cells.	Oxygen	26-32	cadherin 1	Homo sapiens	114-124
19919690-5	2009	We also detected expression of a HIF-1alpha mRNA splice variant that lacks part of the oxygen-dependent regulation domain in WM1366 and WM9 melanoma cells.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19580395-2	2009	The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2).	Oxygen	79-81	BCL2 apoptosis regulator	Homo sapiens	4-9
19758989-1	2009	Glycolate oxidase is a flavin-dependent, peroxisomal enzyme that oxidizes alpha-hydroxy acids to the corresponding alpha-keto acids, with reduction of oxygen to H(2)O(2).	Oxygen	151-157	hydroxyacid oxidase 2	Homo sapiens	0-17
19244202-8	2009	In conclusion, oxidation of Trx1 and sustained Txnip expression in the lungs of newborn mice exposed to 85% oxygen is likely to severely attenuate normal Trx1 function.	Oxygen	108-114	thioredoxin interacting protein	Mus musculus	47-52
19762474-2	2009	Hypoxia-inducible factor-1 (HIF-1) can activate expression of a broad range of genes that mediate many of the adaptive responses to decreased oxygen concentration, such as enhanced glucose uptake and formation of new blood vessels.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19762474-2	2009	Hypoxia-inducible factor-1 (HIF-1) can activate expression of a broad range of genes that mediate many of the adaptive responses to decreased oxygen concentration, such as enhanced glucose uptake and formation of new blood vessels.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19583705-2	2009	Here we investigated whether the expression of TrkB and other neurotrophin receptors is oxygen-sensitive also in vivo, and explored the functional consequences of an oxygen-regulated TrkB expression.	Oxygen	88-94	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	47-51
19583705-2	2009	Here we investigated whether the expression of TrkB and other neurotrophin receptors is oxygen-sensitive also in vivo, and explored the functional consequences of an oxygen-regulated TrkB expression.	Oxygen	166-172	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	183-187
19580395-4	2009	In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen.	Oxygen	112-118	BCL2 apoptosis regulator	Homo sapiens	45-50
19622015-2	2009	Enzymatically active MPO, together with hydrogen peroxide and chloride, produces the powerful oxidant hypochlorous acid and is a key contributor to the oxygen-dependent microbicidal activity of phagocytes.	Oxygen	152-158	myeloperoxidase	Homo sapiens	21-24
19924984-8	2009	The high CE for the GF1 separator was attributed to a low oxygen mass transfer coefficient (k(O) = 5.0 x 10(-5) cm/s).	Oxygen	58-64	GATA binding protein 1	Homo sapiens	20-23
19775891-1	2009	Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.	Oxygen	57-63	egl-9 family hypoxia inducible factor 1	Homo sapiens	79-106
19775891-1	2009	Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.	Oxygen	57-63	egl-9 family hypoxia inducible factor 1	Homo sapiens	108-112
19756382-2	2009	It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread oxygen-sensing mechanism.	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-122
19877306-1	2009	OBJECTIVE: Myeloperoxidase catalyzes the formation of reactive oxygen metabolites in neutrophils and monocytes.	Oxygen	63-69	myeloperoxidase	Homo sapiens	11-26
19924984-9	2009	The GF1 and JC materials differed in the amount of biomass that accumulated on the separator and its biodegradability, which affected long-term power production and oxygen transport.	Oxygen	165-171	GATA binding protein 1	Homo sapiens	4-7
19737748-8	2009	Remarkably, we find that each of these treatments or mutations eliminates oxygen-dependent degradation of HIF-1 protein, but none of them abolishes EGL-9-mediated repression of HIF-1 transcriptional activity.	Oxygen	74-80	Hypoxia-inducible factor 1	Caenorhabditis elegans	106-111
19788422-6	2009	We show that the engineered SOD-Hb fusion protein retains the oxygen-binding capacity and, moreover, decreases cytotoxic ferrylHb (HbFe(4+)) formation when challenged with superoxide radicals.	Oxygen	62-68	superoxide dismutase 1	Homo sapiens	28-31
19626680-7	2009	At 3% O(2), the activity of CDK9/cyclin T1 was inhibited and Sp1 activity was reduced, whereas the activity of other host cell factors such as CDK2 or NF-kappaB was not affected.	Oxygen	6-10	cyclin dependent kinase 9	Homo sapiens	28-32
19691658-2	2009	In this study, by using a mouse model (designated tg6) that constitutively overexpresses human Epo in an oxygen-independent manner, we have investigated mast cell and macrophage number and distribution in duodenal mucosa using immunohistochemical, morphometric and image analysis methods.	Oxygen	105-111	erythropoietin	Homo sapiens	95-98
19626680-7	2009	At 3% O(2), the activity of CDK9/cyclin T1 was inhibited and Sp1 activity was reduced, whereas the activity of other host cell factors such as CDK2 or NF-kappaB was not affected.	Oxygen	6-10	cyclin T1	Homo sapiens	33-42
19626680-8	2009	CDK9-specific inhibitor ARC was much less efficient at 3% compared to 21% O(2) and also expression of CDK9/cyclin T1-dependent IkappaB inhibitor alpha was repressed.	Oxygen	74-78	cyclin dependent kinase 9	Homo sapiens	0-4
19626680-8	2009	CDK9-specific inhibitor ARC was much less efficient at 3% compared to 21% O(2) and also expression of CDK9/cyclin T1-dependent IkappaB inhibitor alpha was repressed.	Oxygen	74-78	cyclin T1	Homo sapiens	107-116
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	57-61	cyclin dependent kinase 9	Homo sapiens	120-124
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	57-61	cyclin T1	Homo sapiens	125-134
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	57-61	nuclear factor kappa B subunit 1	Homo sapiens	209-218
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	78-82	cyclin dependent kinase 9	Homo sapiens	120-124
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	78-82	cyclin T1	Homo sapiens	125-134
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	78-82	cyclin dependent kinase 9	Homo sapiens	120-124
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	78-82	cyclin T1	Homo sapiens	125-134
19744167-7	2009	TNF-alpha and CoCl(2), but not TLR agonists, induced a reduction in complex I-, II- and IV-dependent mitochondrial oxygen consumption.	Oxygen	115-121	tumor necrosis factor	Homo sapiens	0-9
19692634-6	2009	Anti-PECAM/catalase also reduced alveolar edema and attenuated decline in arterial oxygen in mice that underwent unilateral lung ischemia/reperfusion, whereas anti-PECAM/SOD was not effective, implying the key role of H(2)O(2) in tissue damage in this pathology.	Oxygen	83-89	catalase	Mus musculus	11-19
19744167-8	2009	TNF-alpha-associated reduction of cellular oxygen consumption was abolished through inhibition of HIF-1 alpha activity by chetomin (CTM).	Oxygen	43-49	tumor necrosis factor	Homo sapiens	0-9
19744167-8	2009	TNF-alpha-associated reduction of cellular oxygen consumption was abolished through inhibition of HIF-1 alpha activity by chetomin (CTM).	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-109
19745171-8	2009	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	solute carrier family 8 member A1	Rattus norvegicus	11-14
19912970-6	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a nuclear transcription factor with a central role in the regulation of cellular oxygen homeostasis.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
19912970-6	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a nuclear transcription factor with a central role in the regulation of cellular oxygen homeostasis.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19912970-8	2009	HIF-1alpha can also be stabilized under normoxic condition during inflammation and this activation seems to be associated with a prominent pro-inflammatory profile, with lymphocytes dysfunction, and to a reduction in cellular oxygen consumption.	Oxygen	226-232	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19745171-8	2009	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	solute carrier family 8 member A1	Rattus norvegicus	28-32
19762597-4	2009	The stability of FBXL5 itself was regulated, accumulating under iron- and oxygen-replete conditions and degraded upon iron depletion.	Oxygen	74-80	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
19502547-1	2009	Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-133
19502547-1	2009	Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-140
19502547-1	2009	Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-133
19502547-1	2009	Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-140
19762596-4	2009	The F-box substrate adaptor protein FBXL5 was degraded upon iron and oxygen depletion in a process that required an iron-binding hemerythrin-like domain in its N terminus.	Oxygen	69-75	F-box and leucine rich repeat protein 5	Homo sapiens	36-41
19762597-5	2009	FBXL5 contains an iron- and oxygen-binding hemerythrin domain that acted as a ligand-dependent regulatory switch mediating FBXL5"s differential stability.	Oxygen	28-34	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
19762597-5	2009	FBXL5 contains an iron- and oxygen-binding hemerythrin domain that acted as a ligand-dependent regulatory switch mediating FBXL5"s differential stability.	Oxygen	28-34	F-box and leucine rich repeat protein 5	Homo sapiens	123-128
19622751-3	2009	Recent studies showed that nutrient and oxygen starvation during tissue ischemia induce certain ER stress response genes, including GRP78; however, the role of ATF6 in mediating this induction has not been examined.	Oxygen	40-46	heat shock protein family A (Hsp70) member 5	Homo sapiens	132-137
19850204-2	2009	We propose that increased FFA-induced mitochondrial uncoupling and substantial oxygen wastage is closely associated with the generation of reactive oxygen species, inflammatory markers, and the development of insulin resistance.	Oxygen	79-85	insulin	Homo sapiens	209-216
19893619-0	2009	Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
19893619-0	2009	Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.	Oxygen	93-99	vascular endothelial growth factor A	Homo sapiens	29-33
19893619-9	2009	Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
19893619-9	2009	Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations.	Oxygen	185-191	vascular endothelial growth factor A	Homo sapiens	104-108
19893619-9	2009	Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
19855843-5	2009	ROX1 encodes a major oxygen-responding regulator in S. cerevisiae.	Oxygen	21-27	Rox1p	Saccharomyces cerevisiae S288C	0-4
19855843-8	2009	Bioinformatics and stochastic analyses of the Rox1p-binding site (YYYATTGTTCTC) in the upstream sequences of the S. cerevisiae Rox1p-mediated genes and of the K. lactis orthologs also indicated that K. lactis lacks the specific gene system responding to oxygen limiting environment, which is present in the "post-WGD" genome of S. cerevisiae.	Oxygen	254-260	Rox1p	Saccharomyces cerevisiae S288C	46-51
21578144-2	2009	The Co(III) cation has site symmetry m, and is coordinated by four oxygen atoms from four bridging pivalate groups, one central O anion and a methanol oxygen atom, forming a distorted octa-hedral geometry.	Oxygen	67-73	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-11
19855843-8	2009	Bioinformatics and stochastic analyses of the Rox1p-binding site (YYYATTGTTCTC) in the upstream sequences of the S. cerevisiae Rox1p-mediated genes and of the K. lactis orthologs also indicated that K. lactis lacks the specific gene system responding to oxygen limiting environment, which is present in the "post-WGD" genome of S. cerevisiae.	Oxygen	254-260	Rox1p	Saccharomyces cerevisiae S288C	127-132
21578144-2	2009	The Co(III) cation has site symmetry m, and is coordinated by four oxygen atoms from four bridging pivalate groups, one central O anion and a methanol oxygen atom, forming a distorted octa-hedral geometry.	Oxygen	151-157	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-11
19625206-1	2009	4-Hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate synthase (HMS) are the only two known members of the alpha-keto acid-dependent oxygenases that adopt the fold common to the vicinal oxygen chelate superfamily of enzymes.	Oxygen	26-32	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	37-41
19764732-0	2009	An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.	Oxygen	3-9	phosphodiesterase	Escherichia coli	42-59
19520500-0	2009	Clarified sludge (basic oxygen furnace sludge)--an adsorbent for removal of Pb(II) from aqueous solutions--kinetics, thermodynamics and desorption studies.	Oxygen	24-30	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-82
19520500-1	2009	The basic oxygen furnace waste generated in steel plant has been used as a low cost adsorbent for the removal of Pb(II) from aqueous solution.	Oxygen	10-16	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
19631610-0	2009	Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.	Oxygen	9-15	egl-9 family hypoxia inducible factor 1	Homo sapiens	127-131
19845620-1	2009	Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB).	Oxygen	109-115	nuclear factor kappa B subunit 1	Homo sapiens	220-229
19845620-5	2009	Recent studies have demonstrated that similar oxygen-sensing mechanisms are employed in conferring oxygen sensitivity to both HIF and NF-kappaB-dependent gene expression.	Oxygen	46-52	nuclear factor kappa B subunit 1	Homo sapiens	134-143
19845620-5	2009	Recent studies have demonstrated that similar oxygen-sensing mechanisms are employed in conferring oxygen sensitivity to both HIF and NF-kappaB-dependent gene expression.	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	134-143
19366737-3	2009	Using pharmacological and immunochemical methods, we tested the role of mitochondrial permeability transition (MPT) and the Bcl-2 proteins in oxygen-dependent radiosensitivity.	Oxygen	142-148	BCL2 apoptosis regulator	Homo sapiens	124-129
19366737-7	2009	Nor was evidence found for the modulation of oxygen-dependent radiosensitivity by Bax/Bcl-2 signalling, mitochondrial ATP-dependent potassium (mitoK(ATP)) channels or mitochondrial Ca(2+) uptake.	Oxygen	45-51	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
19366737-7	2009	Nor was evidence found for the modulation of oxygen-dependent radiosensitivity by Bax/Bcl-2 signalling, mitochondrial ATP-dependent potassium (mitoK(ATP)) channels or mitochondrial Ca(2+) uptake.	Oxygen	45-51	BCL2 apoptosis regulator	Homo sapiens	86-91
19789328-1	2009	PURPOSE: Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular response to low oxygen, functions as a transcription factor for a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-35
19789328-1	2009	PURPOSE: Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular response to low oxygen, functions as a transcription factor for a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
19789328-1	2009	PURPOSE: Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular response to low oxygen, functions as a transcription factor for a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-35
19789328-1	2009	PURPOSE: Hypoxia inducible factor-1 (HIF-1), the central mediator of the cellular response to low oxygen, functions as a transcription factor for a broad range of genes that provide adaptive responses to oxygen deprivation.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
19168699-9	2009	Taken together, our results suggest that IL-6 induces Bcl-2 expression to perform cytoprotective functions in response to oxygen toxicity, and that this effect is mediated by alterations in the interactions between Bak and Mfns.	Oxygen	122-128	interleukin 6	Mus musculus	41-45
19168699-9	2009	Taken together, our results suggest that IL-6 induces Bcl-2 expression to perform cytoprotective functions in response to oxygen toxicity, and that this effect is mediated by alterations in the interactions between Bak and Mfns.	Oxygen	122-128	B cell leukemia/lymphoma 2	Mus musculus	54-59
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Oxygen	190-196	caspase 3	Homo sapiens	243-252
19738058-0	2009	c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-46
19738058-2	2009	We report here that c-Jun associates with HIF-1alpha via its oxygen-dependent degradation domain, masks the sites for ubiquitination, and thus protects HIF-1alpha from proteasome-executing degradation.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
19738058-2	2009	We report here that c-Jun associates with HIF-1alpha via its oxygen-dependent degradation domain, masks the sites for ubiquitination, and thus protects HIF-1alpha from proteasome-executing degradation.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
19777592-2	2009	The EF5-positive tissues were also specifically positive for nuclear-localized hypoxia inducible factor-1 alpha (HIF-1alpha), the oxygen-sensitive component of the hypoxia inducible factor-1 (HIF-1) heterodimer.	Oxygen	130-136	hypoxia inducible factor 1 alpha subunit	Gallus gallus	79-111
19777592-2	2009	The EF5-positive tissues were also specifically positive for nuclear-localized hypoxia inducible factor-1 alpha (HIF-1alpha), the oxygen-sensitive component of the hypoxia inducible factor-1 (HIF-1) heterodimer.	Oxygen	130-136	hypoxia inducible factor 1 alpha subunit	Gallus gallus	113-123
19625206-6	2009	This mini-review summarizes the structural and mechanistic data assembled in recent years for HPPD and HMS in the context of both their roles in nature and the vicinal oxygen chelate and alpha-keto acid-dependent oxygenases superfamilies.	Oxygen	168-174	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	94-98
19670369-3	2009	Lowering of O(2) from 21 to 5% induced upregulation of cofilin-1, cyclophilin A, tubulin and tubulin fragments, a fragment of glucose-regulated protein 78 (Grp78) and calmodulin.	Oxygen	12-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	126-154
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase like 2	Homo sapiens	30-35
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase like 2	Homo sapiens	286-291
19629519-6	2009	O(2) levels in initially oxygenated solutions gassed with N(2) fell to approximately 1% within 2 h. A progressive fall in pH(i) and acid extrusion capacity was observed, with statistically significant effects (P &lt; 0.05) apparent within 3 h. For equine and bovine cell populations subjected to step change in O(2) by resuspension in hypoxic (1%) solutions, a decline in acid extrusion and pH(i) was observed within 10 min and continued throughout the recording period.	Oxygen	0-4	glucose-6-phosphate isomerase	Bos taurus	391-396
19712973-0	2009	Differential regulation of human PlGF gene expression in trophoblast and nontrophoblast cells by oxygen tension.	Oxygen	97-103	placental growth factor	Homo sapiens	33-37
19712973-1	2009	OBJECTIVE: To determine the mechanism for differential effects of low oxygen tension on human PlGF gene transcription in trophoblast and nontrophoblast cells.	Oxygen	70-76	placental growth factor	Homo sapiens	94-98
19712973-4	2009	RESULTS: PlGF transcription is specifically inhibited by low oxygen tension in trophoblast but is induced in some nontrophoblast cells.	Oxygen	61-67	placental growth factor	Homo sapiens	9-13
19712973-6	2009	CONCLUSIONS: These results suggest that transcriptional repression of PlGF gene expression occurs in human trophoblast exposed to low oxygen tension but that PlGF transcription is stimulated in certain hypoxic nontrophoblast cells.	Oxygen	134-140	placental growth factor	Homo sapiens	70-74
19670369-3	2009	Lowering of O(2) from 21 to 5% induced upregulation of cofilin-1, cyclophilin A, tubulin and tubulin fragments, a fragment of glucose-regulated protein 78 (Grp78) and calmodulin.	Oxygen	12-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	156-161
19670369-3	2009	Lowering of O(2) from 21 to 5% induced upregulation of cofilin-1, cyclophilin A, tubulin and tubulin fragments, a fragment of glucose-regulated protein 78 (Grp78) and calmodulin.	Oxygen	12-16	calmodulin 1	Homo sapiens	167-177
19670369-4	2009	The upregulation of Grp78 suggested that ER stress proteins were altered and indeed Grp94 and caspase 12 expression were increased in cells exposed to 5% O(2).	Oxygen	154-158	heat shock protein family A (Hsp70) member 5	Homo sapiens	20-25
19670369-8	2009	The present investigations reveal that lowering O(2), probably in part through hypoxia-inducible factor, alter the expression of a series of proteins mainly involved in cytoskeletal changes (e.g. cofilin-1, tubulin, and beta-actin) and in ER stress/apoptosis (e.g. Grp78/94, caspase 12, and cyclophilin A).	Oxygen	48-52	heat shock protein family A (Hsp70) member 5	Homo sapiens	265-270
19805328-3	2009	The Nrf2-ARE pathway is activated in response to reactive oxygen species to trigger the simultaneous expression of numerous protective enzymes and scavengers.	Oxygen	58-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
19849936-10	2009	Arterial oxygen saturation was negatively correlated with serum VEGF (p&lt;0.01) and LEP levels (p&lt;0.01) in the CCHD group.	Oxygen	9-15	vascular endothelial growth factor A	Homo sapiens	64-68
19860242-11	2009	SpO2 was 85-93% with O2 inhalation at 1l x min(-1) during the operation.	Oxygen	2-4	CD59 molecule (CD59 blood group)	Homo sapiens	43-49
19553016-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transciptional regulator of cellular and systemic oxygen homeostasis.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
19707690-0	2009	The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O(2) and CO binding to iron protoporphyrin IX.	Oxygen	94-98	albumin	Homo sapiens	76-89
19707690-1	2009	Complexation of iron(II) protoporphyrin IX (Fe(2+)PP) into a genetically engineered heme pocket on recombinant human serum albumin (rHSA) creates an artificial hemoprotein which can bind O(2) reversibly at room temperature.	Oxygen	187-191	albumin	Homo sapiens	117-130
19559788-2	2009	Nitrosative species were generated by 3-morpholinesydnonymine (SIN1) decomposition, using cyt c heme iron and/or molecular oxygen as electron acceptor.	Oxygen	123-129	MAPK associated protein 1	Homo sapiens	63-67
19553016-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transciptional regulator of cellular and systemic oxygen homeostasis.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19658385-8	2009	The octahedral sites of Co(II) are occupied by oxygens, thereby reflecting the nature of interactions between the divalent metal ion and quinic acid.	Oxygen	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19591804-0	2009	The critical iron-oxygen intermediate in human aromatase.	Oxygen	18-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	47-56
19753310-3	2009	The effect of transient hypoxia treatment (1% oxygen, 4 h/day) on TGFbeta1 (5 ng/ml)-induced alpha-smooth muscle actin (alpha-SM actin) expression was examined by immunofluorescence, flow cytometry, and immunocytochemistry 72 h after treatment.	Oxygen	46-52	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	66-74
19658385-9	2009	The magnetic and EPR data on 1 and 3 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin of S = 1/2.	Oxygen	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
19745533-9	2009	The electrode gave a well-defined current-potential curve with a steady state limiting current due to the PA1-[Fe(CN)6](4-/3-) polyion complex-mediated bioelectrocatalytic current for the reduction of O2.	Oxygen	201-203	PAXIP1 associated glutamate rich protein 1	Homo sapiens	106-109
19572935-13	2009	Finally, vasopressin impaired the renal oxygen demand/supply relationship.	Oxygen	40-46	arginine vasopressin	Homo sapiens	9-20
19426704-7	2009	Steady-state oxygen consumption due to choline oxidation in kidney mitochondria was measurable at 37 degrees C (125+/-6 pmol O2/min/mg mitochondrial protein), in the absence of other mitochondrial electron transport chain substrates and the choline transporter was shown to be the major site of control (96+/-4%) over choline oxidation flux in isolated kidney mitochondria.	Oxygen	13-19	solute carrier family 6 member 8	Rattus norvegicus	241-260
19789122-3	2009	EPO synthesis by peritubular cells in the kidney is regulated by oxygen concentration and must lead adaptation of the organism to face many different physiological situations.	Oxygen	65-71	erythropoietin	Homo sapiens	0-3
19716583-6	2009	Mobilization through microbially mediated As(V) and Fe(III) reduction occurred both in the presence and absence of oxygen.	Oxygen	115-121	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	42-47
19764241-2	2009	Two AChE immobilization strategies are proposed based on the composite film with hydrophobic and hydrophilic surface tailored by oxygen plasma.	Oxygen	129-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
19423615-1	2009	The hypoxia inducible factor-1alpha (HIF1alpha) is a key regulator of oxygen homeostasis, modulating cell survival, and growth in cells exposed to hypoxia.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
19423615-1	2009	The hypoxia inducible factor-1alpha (HIF1alpha) is a key regulator of oxygen homeostasis, modulating cell survival, and growth in cells exposed to hypoxia.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-46
20633497-1	2009	INTRODUCTION: Superoxide dismutase (SOD) is one of the most important antioxidant enzymes present in all oxygen-metabolizing cells.	Oxygen	105-111	superoxide dismutase 1	Homo sapiens	14-34
19500668-4	2009	The enzyme activity toward single oxygen-induced DNA damage and mRNA expression levels of Ercc1, Neil1, and Ogg1 remained unaltered with age.	Oxygen	34-40	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	97-102
19482077-1	2009	Copper/zinc-superoxide dismutase (SOD1) plays a protective role in cells by catalyzing the conversion of the superoxide anion into molecular oxygen and hydrogen peroxide.	Oxygen	141-147	superoxide dismutase 1, soluble	Mus musculus	34-38
20633497-1	2009	INTRODUCTION: Superoxide dismutase (SOD) is one of the most important antioxidant enzymes present in all oxygen-metabolizing cells.	Oxygen	105-111	superoxide dismutase 1	Homo sapiens	36-39
19822105-5	2009	This effect may be partly due to the possibility that leghemoglobin may mimic the function of cytoglobin by shuttling oxygen to prolyl-4-hydroxylase, the enzyme responsible for oxidizing proline residues in procollagen bundles.	Oxygen	118-124	cytoglobin	Homo sapiens	94-104
19441077-4	2009	At lower O2 tensions, hypoxia-inducible factor 1alpha (HIF1alpha) facilitates signal transduction pathways that promote self-renewal (e.g., Notch) and inhibits pathways that promote NSC differentiation or apoptosis (e.g., bone morphogenetic proteins).	Oxygen	9-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-53
19441077-4	2009	At lower O2 tensions, hypoxia-inducible factor 1alpha (HIF1alpha) facilitates signal transduction pathways that promote self-renewal (e.g., Notch) and inhibits pathways that promote NSC differentiation or apoptosis (e.g., bone morphogenetic proteins).	Oxygen	9-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-64
19441077-5	2009	Increasing O2 tension degrades HIF1alpha, thus promoting differentiation or apoptosis of NSCs and progenitors.	Oxygen	11-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-40
19365612-10	2009	These results demonstrated that PEG 10 wt% modified PLA HbP with suitable size, surface charge, and surface hydrophilicity, has a promising potential as long-circulating oxygen carriers with desirable biocompatibility and biofunctionality.	Oxygen	170-176	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	56-59
19587118-0	2009	Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export.	Oxygen	20-26	similar	Drosophila melanogaster	79-83
19587118-0	2009	Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export.	Oxygen	87-93	similar	Drosophila melanogaster	79-83
19587118-2	2009	We have characterized the mechanism governing Sima oxygen-dependent subcellular localization and found that Sima shuttles continuously between the nucleus and the cytoplasm.	Oxygen	51-57	similar	Drosophila melanogaster	46-50
19587118-2	2009	We have characterized the mechanism governing Sima oxygen-dependent subcellular localization and found that Sima shuttles continuously between the nucleus and the cytoplasm.	Oxygen	51-57	similar	Drosophila melanogaster	108-112
19587118-6	2009	At high oxygen tension rapid nuclear export of Sima occurs, whereas in hypoxia, Sima nuclear export is largely inhibited.	Oxygen	8-14	similar	Drosophila melanogaster	47-51
19587118-7	2009	HIFalpha/Sima nucleo-cytoplasmic localization is the result of a dynamic equilibrium between nuclear import and nuclear export, and nuclear export is modulated by oxygen tension.	Oxygen	163-169	similar	Drosophila melanogaster	0-8
19587118-7	2009	HIFalpha/Sima nucleo-cytoplasmic localization is the result of a dynamic equilibrium between nuclear import and nuclear export, and nuclear export is modulated by oxygen tension.	Oxygen	163-169	similar	Drosophila melanogaster	9-13
19706450-3	2009	The calculated isotopic fractionation factors for SO2 photolysis give mass independent distributions that are highly sensitive to the atmospheric concentrations of O2, O3, CO2, H2O, CS2, NH3, N2O, H2S, OCS, and SO2 itself.	Oxygen	51-53	chorionic somatomammotropin hormone 2	Homo sapiens	182-185
19505835-6	2009	Measures of exercise performance including maximal oxygen uptake (VO2max) and ventilatory threshold (VeT) are impaired in GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition and improved thermoregulation.	Oxygen	51-57	growth hormone 1	Homo sapiens	122-124
19463914-3	2009	The TH-positive neurons cultured in lowered oxygen (3-5% O(2)) had more branches and those branches were longer than those of neurons cultured under 20% O(2) culture conditions.	Oxygen	44-50	tyrosine hydroxylase	Homo sapiens	4-6
19463914-3	2009	The TH-positive neurons cultured in lowered oxygen (3-5% O(2)) had more branches and those branches were longer than those of neurons cultured under 20% O(2) culture conditions.	Oxygen	57-61	tyrosine hydroxylase	Homo sapiens	4-6
19463914-3	2009	The TH-positive neurons cultured in lowered oxygen (3-5% O(2)) had more branches and those branches were longer than those of neurons cultured under 20% O(2) culture conditions.	Oxygen	153-157	tyrosine hydroxylase	Homo sapiens	4-6
19463914-4	2009	Furthermore, more TH-positive cells with mature morphology were observed in the culture containing combined SCM addition and lowered oxygen.	Oxygen	133-139	tyrosine hydroxylase	Homo sapiens	18-20
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	erythropoietin	Homo sapiens	54-68
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	erythropoietin	Homo sapiens	70-73
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	paired like homeodomain 3	Homo sapiens	169-174
19601593-9	2009	The Abeta-Fe(II)-NTA complex electrogenerated from the Abeta-Fe(III)-NTA complex was also found to catalyze the reduction of oxygen to produce H(2)O(2).	Oxygen	125-131	amyloid beta precursor protein	Homo sapiens	4-9
19601593-9	2009	The Abeta-Fe(II)-NTA complex electrogenerated from the Abeta-Fe(III)-NTA complex was also found to catalyze the reduction of oxygen to produce H(2)O(2).	Oxygen	125-131	amyloid beta precursor protein	Homo sapiens	55-60
19546213-2	2009	Whereas PHD1 and PHD3 proteolysis has been shown to be regulated by Siah2 ubiquitin E3 ligase-mediated polyubiquitylation and proteasomal destruction, protein regulation of the main oxygen sensor responsible for hypoxia-inducible factor alpha regulation, PHD2, remained unknown.	Oxygen	182-188	egl-9 family hypoxia inducible factor 1	Homo sapiens	255-259
19360424-2	2009	Hypoxia inducible factor-1 alpha (HIF-1alpha) is an inducible transcription factor whose activity is dependent on environmental conditions, most notably oxygen levels and cellular stress.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
19360424-2	2009	Hypoxia inducible factor-1 alpha (HIF-1alpha) is an inducible transcription factor whose activity is dependent on environmental conditions, most notably oxygen levels and cellular stress.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
19542903-4	2009	Lung IL-1 alpha and -1 beta contents were increased after a 4-d exposure to 60% O2.	Oxygen	80-82	interleukin 1 alpha	Rattus norvegicus	5-27
19479945-3	2009	HIF-1 is a key regulator of the response of mammalian cells to oxygen deprivation and plays critical roles in the adaptation of tumor cells to a hypoxic microenvironment.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19505835-6	2009	Measures of exercise performance including maximal oxygen uptake (VO2max) and ventilatory threshold (VeT) are impaired in GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition and improved thermoregulation.	Oxygen	215-221	growth hormone 1	Homo sapiens	122-124
19470762-4	2009	Pseudohypoxia requires the oxygen-independent stabilization of the alpha subunit of the hypoxia-inducible transcription factor (HIF-1alpha).	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
19666350-6	2009	Renal denervation and angiotensin II type 1 receptor antagonist, but not bilateral ureter dissection, abolished the reduction in cortex oxygen tension and microcirculation, increased renal ROS production, increased perivascular monocyte/macrophage infiltration, and led to endothelial ICAM-1 overexpression in the kidney.	Oxygen	136-142	angiotensin II receptor, type 1b	Rattus norvegicus	22-52
19689405-2	2009	One such factor is hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor induced by low oxygen conditions and found in high levels in malignant solid tumors, but not in normal tissues or slow-growing tumors.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-50
19689405-2	2009	One such factor is hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor induced by low oxygen conditions and found in high levels in malignant solid tumors, but not in normal tissues or slow-growing tumors.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
19689405-8	2009	HIF-1alpha action may also modulate mitochondrial function and oxygen consumption by inactivating the pyruvate dehydrogenase complex in some tumor types, or by modulating cytochrome c oxidase subunit 4 expression to increase oxidative phosphorylation in other cancer cell lines.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19491311-1	2009	The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-51
19491311-1	2009	The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
19624909-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha), a nuclear transcriptional factor, is constitutively expressed in mammalian cells under hypoxia, which contributes a lot to the regulation of internal O2 homeostasis.	Oxygen	196-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
19390487-3	2009	Prolonged exposure of fetal ductus to PGE2 in vitro increased the expression of CaL- and K+-channel genes (CaLalpha1c, CaLbeta2, Kir6.1, and Kv1.5, which regulate oxygen-induced constriction) without affecting the genes that regulate Rho-kinase-mediated calcium sensitization.	Oxygen	163-169	potassium voltage-gated channel, shaker-related subfamily, member 5	Mus musculus	141-146
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Oxygen	401-407	amyloid beta precursor protein	Homo sapiens	80-84
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Oxygen	401-407	amyloid beta precursor protein	Homo sapiens	198-202
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Oxygen	401-407	amyloid beta precursor protein	Homo sapiens	198-202
19433855-5	2009	Treating NY1DD mice with anti-CD1d antibody to inhibit iNKT cell activation reverses baseline pulmonary dysfunction manifested as elevated vascular permeability, decreased arterial oxygen saturation, and increased numbers of activated leukocytes.	Oxygen	181-187	CD1d1 antigen	Mus musculus	30-34
19427832-2	2009	HIFs are mainly regulated by a group of prolyl-hydroxylases (PHDs) that in the presence of oxygen, target the HIFalpha subunit for degradation.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-118
19587783-0	2009	Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
19587783-7	2009	We found that GBM cells, when acutely exposed to high oxygen tension, undergo Akt/mTOR pathway activation and that BMP2 acts in an analogous way.	Oxygen	54-60	AKT serine/threonine kinase 1	Homo sapiens	78-81
19587783-7	2009	We found that GBM cells, when acutely exposed to high oxygen tension, undergo Akt/mTOR pathway activation and that BMP2 acts in an analogous way.	Oxygen	54-60	mechanistic target of rapamycin kinase	Homo sapiens	82-86
19587783-10	2009	CONCLUSIONS/SIGNIFICANCE: In this study we elucidate the molecular mechanisms by which two pro-differentiating stimuli, BMP2 and acute high oxygen exposure, control HIF-1alpha stability.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	165-175
19637235-1	2009	Hypoxia-inducible factor-1 (HIF-1), consisting of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, is a master transcriptional activator for cellular response to hypoxia.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19637235-1	2009	Hypoxia-inducible factor-1 (HIF-1), consisting of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, is a master transcriptional activator for cellular response to hypoxia.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19637235-1	2009	Hypoxia-inducible factor-1 (HIF-1), consisting of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, is a master transcriptional activator for cellular response to hypoxia.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
19544425-4	2009	In vitro, in hypoxic (1% oxygen) and serum-deprived conditions that simulate in vivo ischemia, fibroblast growth factor-2 (FGF2) significantly reduced hADSC apoptosis and enhanced angiogenic growth factor secretion.	Oxygen	25-31	fibroblast growth factor 2	Homo sapiens	95-121
19544425-4	2009	In vitro, in hypoxic (1% oxygen) and serum-deprived conditions that simulate in vivo ischemia, fibroblast growth factor-2 (FGF2) significantly reduced hADSC apoptosis and enhanced angiogenic growth factor secretion.	Oxygen	25-31	fibroblast growth factor 2	Homo sapiens	123-127
19646254-5	2009	Mechanistic study demonstrated that genomic DNA fragmentation and phosphatidylserine externalization occurred where increase of intracellular singlet oxygen level triggers the phosphorylation of c-Jun N-terminal Kinase (JNK) and leads to activation of intrinsic apoptotic caspases cascade during the Pa-PDT treatment.	Oxygen	150-156	mitogen-activated protein kinase 8	Homo sapiens	195-218
19646254-5	2009	Mechanistic study demonstrated that genomic DNA fragmentation and phosphatidylserine externalization occurred where increase of intracellular singlet oxygen level triggers the phosphorylation of c-Jun N-terminal Kinase (JNK) and leads to activation of intrinsic apoptotic caspases cascade during the Pa-PDT treatment.	Oxygen	150-156	mitogen-activated protein kinase 8	Homo sapiens	220-223
19633713-9	2009	These data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging.	Oxygen	190-196	Hypoxia-inducible factor 1	Caenorhabditis elegans	21-26
19473970-0	2009	FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells.	Oxygen	17-23	forkhead box O3	Homo sapiens	0-6
19473970-11	2009	We conclude that FOXO3a regulates oxygen-dependent changes in expression of TNFR2 in HDMECs, controlling sensitivity to TNF-mediated apoptosis.	Oxygen	34-40	forkhead box O3	Homo sapiens	17-23
19473970-11	2009	We conclude that FOXO3a regulates oxygen-dependent changes in expression of TNFR2 in HDMECs, controlling sensitivity to TNF-mediated apoptosis.	Oxygen	34-40	tumor necrosis factor	Homo sapiens	76-79
19604478-4	2009	We report crystal structures of the catalytic domain of PHD2, the most important of the human PHDs, in complex with the C-terminal oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	131-137	egl-9 family hypoxia inducible factor 1	Homo sapiens	56-60
19604478-4	2009	We report crystal structures of the catalytic domain of PHD2, the most important of the human PHDs, in complex with the C-terminal oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	170-180
19624909-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha), a nuclear transcriptional factor, is constitutively expressed in mammalian cells under hypoxia, which contributes a lot to the regulation of internal O2 homeostasis.	Oxygen	196-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19501525-6	2009	The second aim was to determine if the link between varying levels of the cytokine, IL-10, and the expression/release of TNF-alpha was oxygen dependent, and whether there was a concurrent change in sFlt-1.	Oxygen	135-141	tumor necrosis factor	Homo sapiens	121-130
19298791-0	2009	Response of blood vessels in vitro to hyperbaric oxygen (HBO): modulation of VEGF and NO(x) release by external lactate or arginine.	Oxygen	49-55	vascular endothelial growth factor A	Homo sapiens	77-81
19233690-6	2009	Gene Ontology analysis indicated a significant alteration of oxygen transport (increased hemoglobin gene expression) and lipid metabolism [including monoglyceride lipase and low density lipoprotein receptor-related protein 5 (LRP5) gene].	Oxygen	61-67	LDL receptor related protein 5	Homo sapiens	174-224
19233690-6	2009	Gene Ontology analysis indicated a significant alteration of oxygen transport (increased hemoglobin gene expression) and lipid metabolism [including monoglyceride lipase and low density lipoprotein receptor-related protein 5 (LRP5) gene].	Oxygen	61-67	LDL receptor related protein 5	Homo sapiens	226-230
19456861-10	2009	However, the effect of IkappaB alpha on HIF-1alpha activity was only observed in atmospheres containing 1% or more of oxygen.	Oxygen	118-124	NFKB inhibitor alpha	Homo sapiens	23-36
19374898-5	2009	TAT-mGluR1 peptide prevented oxygen/glucose deprivation- (OGD) and hypoxia/ischemia- (H/I) induced neuronal death in cultured hippocampal slices and neonatal rats, respectively.	Oxygen	29-35	glutamate metabotropic receptor 1	Rattus norvegicus	4-10
19332053-4	2009	The discovery that HIF-1 activity is not only restricted to pathological conditions of reduced oxygen availability but also is needed for the normal O2-homeostasis by regulating O2-delivery and consumption opens a diverse spectrum of so far unappreciated HIF-1 functions in several organs, including the immune system.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-24
19332053-4	2009	The discovery that HIF-1 activity is not only restricted to pathological conditions of reduced oxygen availability but also is needed for the normal O2-homeostasis by regulating O2-delivery and consumption opens a diverse spectrum of so far unappreciated HIF-1 functions in several organs, including the immune system.	Oxygen	149-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-24
19332053-4	2009	The discovery that HIF-1 activity is not only restricted to pathological conditions of reduced oxygen availability but also is needed for the normal O2-homeostasis by regulating O2-delivery and consumption opens a diverse spectrum of so far unappreciated HIF-1 functions in several organs, including the immune system.	Oxygen	178-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-24
19301028-0	2009	Suppression of retinal neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy.	Oxygen	90-96	nitric oxide synthase 2, inducible	Mus musculus	49-53
19456861-10	2009	However, the effect of IkappaB alpha on HIF-1alpha activity was only observed in atmospheres containing 1% or more of oxygen.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
19496610-1	2009	Copper interactions with the beta-amyloid peptide (Abeta) are believed to play a role in Alzheimer"s disease (AD), in particular due to production of reactive oxygen species and Cu(2+)-mediated oligomerization.	Oxygen	159-165	amyloid beta precursor protein	Homo sapiens	29-49
19519225-8	2009	Enhanced mitochondrial and angiogenic protein expression in human muscle with exercise up to 4000 m is related to the reduction in intramuscular oxygen content below 1% (8 torr), when the master regulator of hypoxia-dependent gene expression, HIF-1alpha, is stabilized.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	243-253
19401150-1	2009	FIH-1, factor inhibiting hypoxia-inducible factor-1 (HIF-1), regulates oxygen sensing by hydroxylating an asparagine within HIF-alpha.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
19401150-4	2009	We determined the contributions of substrate sequence composition and length and of oxygen concentration to the FIH-1-binding and/or hydroxylation of Notch1-4 and compared them with those for HIF-1alpha.	Oxygen	84-90	notch receptor 1	Homo sapiens	150-156
19401150-10	2009	Importantly, we demonstrate that the K(m) of FIH-1 for oxygen at the preferred Site 1 of Notch1-3, 10-19 microM, is an order of magnitude lower than that for Site 2 or HIF-1alpha.	Oxygen	55-61	notch receptor 1	Homo sapiens	89-95
19488048-7	2009	NPY and AgRP increased feeding and decreased oxygen consumption, with the effects of AgRP being more prolonged.	Oxygen	45-51	neuropeptide Y	Rattus norvegicus	0-3
19488048-8	2009	In contrast, orexin-A increased both feeding and oxygen consumption, consistent with an observed increase in activity.	Oxygen	49-55	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
21084849-3	2009	In order to enhance intracellular oxygen delivery and utilization, islets were transfected with a plasmid encoding cytoglobin, an intracellular oxygen binding protein.	Oxygen	34-40	cytoglobin	Homo sapiens	115-125
21084849-3	2009	In order to enhance intracellular oxygen delivery and utilization, islets were transfected with a plasmid encoding cytoglobin, an intracellular oxygen binding protein.	Oxygen	144-150	cytoglobin	Homo sapiens	115-125
21084849-6	2009	Cytoglobin treated islets maintained a normal rate of oxygen consumption, while untreated islets increased the rate of oxygen consumption caused by a shift to anaerobic metabolism and increased reactive oxygen specie synthesis.	Oxygen	54-60	cytoglobin	Homo sapiens	0-10
19496610-1	2009	Copper interactions with the beta-amyloid peptide (Abeta) are believed to play a role in Alzheimer"s disease (AD), in particular due to production of reactive oxygen species and Cu(2+)-mediated oligomerization.	Oxygen	159-165	amyloid beta precursor protein	Homo sapiens	51-56
19496610-3	2009	To date, the identity of the oxygen ligand(s) involved in Cu(2+) coordination by Abeta has remained unclear.	Oxygen	29-35	amyloid beta precursor protein	Homo sapiens	81-86
19412833-0	2009	Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control.	Oxygen	21-27	insulin	Homo sapiens	0-7
19556054-11	2009	The effect of denitrification is further supported as mean groundwater NO3-N was significantly (P&lt;0.05) related to groundwater N2/Ar ratio, redox potential (Eh), dissolved O2 and N2 and was close to being significant with N2O (P=0.08).	Oxygen	175-177	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
20715691-5	2009	These days, SGC also has continuous cardiac output measurement system and mixed venous blood oxygen saturation monitoring system.	Oxygen	93-99	sarcoglycan beta	Homo sapiens	12-15
19659655-2	2009	This report describes a patient with BAC refractory to conventional chemotherapy but with a partial response to S-1, oral fluoropyrimidine, resulting in symptom improvement and weaning from oxygen supplementation.	Oxygen	190-196	proteasome 26S subunit, non-ATPase 1	Homo sapiens	112-115
19580403-3	2009	MATERIALS &amp; METHODS: In this investigation, the impact of available oxygen was investigated to identify optimal conditions for human ASC chondrogenesis in vitro.	Oxygen	72-78	PYD and CARD domain containing	Homo sapiens	137-140
19287338-4	2009	In this review, we discuss transcription factors whose activity is regulated by oxygen, including nuclear factor, erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), p53, nuclear factor kappaB (NF-kappaB), signal transducers and activators of transcription protein (STAT), and ccat/enhancer binding protein (CEBP).	Oxygen	80-86	NFE2 like bZIP transcription factor 2	Homo sapiens	98-142
19287338-4	2009	In this review, we discuss transcription factors whose activity is regulated by oxygen, including nuclear factor, erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), p53, nuclear factor kappaB (NF-kappaB), signal transducers and activators of transcription protein (STAT), and ccat/enhancer binding protein (CEBP).	Oxygen	80-86	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
19287338-4	2009	In this review, we discuss transcription factors whose activity is regulated by oxygen, including nuclear factor, erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), p53, nuclear factor kappaB (NF-kappaB), signal transducers and activators of transcription protein (STAT), and ccat/enhancer binding protein (CEBP).	Oxygen	80-86	CCAAT enhancer binding protein alpha	Homo sapiens	290-319
19287338-4	2009	In this review, we discuss transcription factors whose activity is regulated by oxygen, including nuclear factor, erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), p53, nuclear factor kappaB (NF-kappaB), signal transducers and activators of transcription protein (STAT), and ccat/enhancer binding protein (CEBP).	Oxygen	80-86	CCAAT enhancer binding protein alpha	Homo sapiens	321-325
19304911-2	2009	Here, we tested the hypothesis that PHD2, a prolyl hydroxylase domain (PHD)-containing O(2) sensor, modulates growth factor-induced proliferative responses of human pulmonary artery SMC (HPASMC).	Oxygen	87-91	egl-9 family hypoxia inducible factor 1	Homo sapiens	36-40
19650992-7	2009	RESULTS: Compared with the control group, the 3% and 5% oxygen treatment groups significantly increased the adhesion, migration and invasion abilities of K562 cells (p&lt;0.05 or &lt;0.01), and up-regulated the protein level of HIF-1alpha and the mRNA levels of HIF-1alpha,VEGF, MMP-9 and MMP-2 (p&lt;0.05 or 0.01).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	228-238
19650992-7	2009	RESULTS: Compared with the control group, the 3% and 5% oxygen treatment groups significantly increased the adhesion, migration and invasion abilities of K562 cells (p&lt;0.05 or &lt;0.01), and up-regulated the protein level of HIF-1alpha and the mRNA levels of HIF-1alpha,VEGF, MMP-9 and MMP-2 (p&lt;0.05 or 0.01).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	262-272
19650992-7	2009	RESULTS: Compared with the control group, the 3% and 5% oxygen treatment groups significantly increased the adhesion, migration and invasion abilities of K562 cells (p&lt;0.05 or &lt;0.01), and up-regulated the protein level of HIF-1alpha and the mRNA levels of HIF-1alpha,VEGF, MMP-9 and MMP-2 (p&lt;0.05 or 0.01).	Oxygen	56-62	vascular endothelial growth factor A	Homo sapiens	273-277
19487805-3	2009	The microsized grains of the commercially available ZnO:Zn (P 15) were reduced to the nanometre scale by pulsed laser ablation at an oxygen ambient pressure of 10 kPa.	Oxygen	133-139	cyclin dependent kinase inhibitor 2B	Homo sapiens	60-64
19432395-11	2009	We suggest that the extensive set of ionic bonds and H-bonds between PsaC and the PsaA/PsaB heterodimer has evolved to ensure an exceedingly tight binding interface, thereby rendering the [4Fe-4S] clusters in PsaC inaccessible to dioxygen at the onset of oxygenic photosynthesis.	Oxygen	230-238	fatty acid amide hydrolase	Homo sapiens	87-91
19328848-5	2009	OH-Cbl and CN(2)-Cbi prevented binding of the oxygen analog carbon monoxide (CO) to the reduced NOS1 and NOS2 heme active site.	Oxygen	46-52	nitric oxide synthase 2, inducible	Mus musculus	105-109
19610677-8	2009	The KIEs in the leaving group oxygens (the beta nonbridge and the beta-gamma bridge oxygens) reveal that chemistry is rate-limiting in GAP(334)-facilitated GTP hydrolysis but only partially rate-limiting in the NF1(333)-facilitated GTP hydrolysis reaction.	Oxygen	30-37	neurofibromin 1	Homo sapiens	211-214
19610677-9	2009	The KIEs in the gamma nonbridge oxygens and the leaving group oxygens reveal that the GAP(334) or NF1(333)-facilitated GTP hydrolysis reaction proceeds through a loose transition state that is similar in nature to the transition state of the GTP hydrolysis catalyzed by Ras alone.	Oxygen	32-39	neurofibromin 1	Homo sapiens	98-101
19610677-9	2009	The KIEs in the gamma nonbridge oxygens and the leaving group oxygens reveal that the GAP(334) or NF1(333)-facilitated GTP hydrolysis reaction proceeds through a loose transition state that is similar in nature to the transition state of the GTP hydrolysis catalyzed by Ras alone.	Oxygen	62-69	neurofibromin 1	Homo sapiens	98-101
19610677-10	2009	However, the KIEs in the pro-S beta, pro-R beta, and beta-gamma oxygens suggest that charge increase on the beta-gamma bridge oxygen is more prominent in the transition states of GAP(334)- and NF1(333)-facilitated reactions than that catalyzed by the intrinsic GTPase activity of Ras.	Oxygen	64-71	neurofibromin 1	Homo sapiens	193-196
19610677-10	2009	However, the KIEs in the pro-S beta, pro-R beta, and beta-gamma oxygens suggest that charge increase on the beta-gamma bridge oxygen is more prominent in the transition states of GAP(334)- and NF1(333)-facilitated reactions than that catalyzed by the intrinsic GTPase activity of Ras.	Oxygen	64-70	neurofibromin 1	Homo sapiens	193-196
19304911-8	2009	Given the role of PHD2 as an oxygen sensor in mammalian cells, these results raise the possibility that PHD2 links VSMC proliferation to O(2) availability.	Oxygen	137-141	egl-9 family hypoxia inducible factor 1	Homo sapiens	104-108
19764568-3	2009	The immunohistochemistry SABC method was performed to test the expression of ASIC1b, ASIC2a, and ASIC3 in neurons of trapezoid body and lateral paragigantocellular nucleus in the control (O2) and intermittent hypoxic (IH) groups of rats.	Oxygen	188-190	acid sensing ion channel subunit 3	Rattus norvegicus	97-102
19960790-2	2009	Treatment with interferon-gamma (IFN-gamma) 1beta has been reported to significantly improve lung function and arterial oxygen saturation in a first randomized controlled trial; unexpectedly, these findings have not been confirmed in a subsequent large placebo-controlled randomized study.	Oxygen	120-126	interferon gamma	Homo sapiens	15-31
19960790-2	2009	Treatment with interferon-gamma (IFN-gamma) 1beta has been reported to significantly improve lung function and arterial oxygen saturation in a first randomized controlled trial; unexpectedly, these findings have not been confirmed in a subsequent large placebo-controlled randomized study.	Oxygen	120-126	interferon gamma	Homo sapiens	33-49
19614926-6	2009	The keratinocyte adherens junction proteins E-cadherin and beta-catenin were dramatically decreased in a regio-specific manner throughout the epidermis following oxygen deprivation.	Oxygen	162-168	cadherin 1	Homo sapiens	44-54
19232460-5	2009	The fusion protein contained the TAT peptide for transduction across membranes, the oxygen-dependent degradation domain of hypoxia-inducible factor-1alpha and wild-type p53.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-154
19406746-6	2009	We subsequently discovered that SMG-1 kinase activity was activated by hypoxia, and depletion of SMG-1 up-regulated MAPK activity under low oxygen.	Oxygen	140-146	mitogen-activated protein kinase 3	Homo sapiens	116-120
19398950-3	2009	We show that depletion of Artemis under typical culture conditions (21% oxygen) leads to a spontaneous phosphorylation and stabilization of p53, and resulting cellular G1 arrest and apoptosis.	Oxygen	72-78	tumor protein p53	Homo sapiens	140-143
19398950-5	2009	Culturing of cellsat 3% oxygen or treatment with an antioxidant abrogated p53 stabilization, indicating that oxidative stress is the responsible cellular stimulus.	Oxygen	24-30	tumor protein p53	Homo sapiens	74-77
19304911-8	2009	Given the role of PHD2 as an oxygen sensor in mammalian cells, these results raise the possibility that PHD2 links VSMC proliferation to O(2) availability.	Oxygen	29-35	egl-9 family hypoxia inducible factor 1	Homo sapiens	18-22
18936945-1	2009	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor that mediates cellular and systemic homeostatic responses to reduced oxygen availability in mammals.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-38
18936945-1	2009	BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor that mediates cellular and systemic homeostatic responses to reduced oxygen availability in mammals.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-45
19423865-2	2009	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of genes essential for adaptation to low oxygen.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19268423-1	2009	This review focuses on the terminal part of the respiratory chain where, macroscopically speaking, electron transfer (ET) switches from the two-electron donor, ubiquinol, to the single-electron carrier, cytochrome c, to finally reduce the four-electron acceptor dioxygen.	Oxygen	262-270	cytochrome c, somatic	Homo sapiens	203-215
19423865-2	2009	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of genes essential for adaptation to low oxygen.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19303436-8	2009	HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19294410-4	2009	Over the first period, maximal oxygen uptake (VO(2max)) remained above 6 l min(-1) which is an outstanding value.	Oxygen	31-37	CD59 molecule (CD59 blood group)	Homo sapiens	75-81
19456874-5	2009	Recent studies reveal that PIS1 expression is regulated at the level of transcription in response to carbon source, oxygen, and zinc.	Oxygen	116-122	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Saccharomyces cerevisiae S288C	27-31
19303436-8	2009	HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-32
19212422-6	2009	Paradoxically, however, enzymatic NO formation from NO synthase (NOS) is inactive during conditions of inadequate oxygen and substrate delivery, such as in ischemia.	Oxygen	114-120	nitric oxide synthase 2	Homo sapiens	52-63
19487569-3	2009	Hypoxia-induced macroautophagy in tumor cells is also HIF1alpha-dependent, with HIF1alpha integrating signals from PDGFRs and oxygen tension.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-63
19487569-3	2009	Hypoxia-induced macroautophagy in tumor cells is also HIF1alpha-dependent, with HIF1alpha integrating signals from PDGFRs and oxygen tension.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-89
24149537-2	2009	OBJECTIVE: The effect of a potentially functional single nucleotide polymorphism (SNP) -174G/C of the IL6 gene (rs1800795) promoter was examined on maximal oxygen uptake (VO2max), body mass index (BMI) and plasma IL-6 levels in response to physical training.	Oxygen	156-162	interleukin 6	Homo sapiens	102-105
19213929-4	2009	When oxygen was made available before the first gasp, allowing autoresuscitation to occur, gasping frequency was decreased and the duration of the gasping period was extended in the Pet-1 mutants compared with wild type, resulting in a nearly threefold increase in the time needed for successful autoresuscitation.	Oxygen	5-11	plasmacytoma expressed transcript 1	Mus musculus	182-187
19455291-6	2009	Recent genetic data indicate that ECs sense an imbalance in oxygen levels, by using the oxygen-sensing prolyl hydroxylase PHD2.	Oxygen	60-66	egl-9 family hypoxia inducible factor 1	Homo sapiens	122-126
19455291-6	2009	Recent genetic data indicate that ECs sense an imbalance in oxygen levels, by using the oxygen-sensing prolyl hydroxylase PHD2.	Oxygen	88-94	egl-9 family hypoxia inducible factor 1	Homo sapiens	122-126
19409199-0	2009	An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation.	Oxygen	87-93	angiopoietin 1	Mus musculus	3-7
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Oxygen	62-68	lactoperoxidase	Homo sapiens	85-88
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Oxygen	62-68	myeloperoxidase	Homo sapiens	144-147
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Oxygen	62-68	lactoperoxidase	Homo sapiens	252-255
19388688-4	2009	A spherical trapping potential was assigned to every SPC/E oxygen, thereby allowing the formation of protonated water molecules.	Oxygen	59-65	proline rich protein gene cluster	Homo sapiens	53-56
19277991-6	2009	HIF-1alpha stabilization was induced in cells cultured in 21% oxygen by treatment with dimethyloxaloglycine (DMOG) or siRNA targeted against PHD2.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19277991-6	2009	HIF-1alpha stabilization was induced in cells cultured in 21% oxygen by treatment with dimethyloxaloglycine (DMOG) or siRNA targeted against PHD2.	Oxygen	62-68	egl-9 family hypoxia inducible factor 1	Homo sapiens	141-145
19409199-0	2009	An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation.	Oxygen	87-93	TEK receptor tyrosine kinase	Mus musculus	8-12
19409199-3	2009	Using embryonic mouse NPCs and the in vitro oxygen and glucose deprivation (OGD) model, we found that angiopoietin-1 (Ang1) could prevent NPCs from OGD-induced apoptosis, as evidenced by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and annexin V labeling.	Oxygen	44-50	angiopoietin 1	Mus musculus	102-116
19409199-3	2009	Using embryonic mouse NPCs and the in vitro oxygen and glucose deprivation (OGD) model, we found that angiopoietin-1 (Ang1) could prevent NPCs from OGD-induced apoptosis, as evidenced by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and annexin V labeling.	Oxygen	44-50	angiopoietin 1	Mus musculus	118-122
19409522-3	2009	Erv1p is reoxidized within this system, transferring its electrons to molecular oxygen through interactions with cytochrome c and cytochrome c oxidase (COX), thereby linking the DRS to the respiratory chain.	Oxygen	80-86	cytochrome c, somatic	Homo sapiens	113-125
19409522-3	2009	Erv1p is reoxidized within this system, transferring its electrons to molecular oxygen through interactions with cytochrome c and cytochrome c oxidase (COX), thereby linking the DRS to the respiratory chain.	Oxygen	80-86	cytochrome c, somatic	Homo sapiens	130-142
19413822-6	2009	At a flow of 2 l x min(-1), oxygen concentrations exceeded 23% only within a few centimetres of the nasal cannula.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	19-25
19225052-8	2009	Our results demonstrate that renal I/R induces early iNOS-dependent microvascular hypoxia in disrupting the balance between microvascular oxygen supply and Vo(2)(ren), whereas endothelial NO synthase activity is compulsory for the maintenance of this balance.	Oxygen	138-144	nitric oxide synthase 2	Rattus norvegicus	53-57
19345587-9	2009	Choline presence and methylene replacement of the choline oxygen were detrimental to ATX recognition.	Oxygen	58-64	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	85-88
19377289-0	2009	HAF  : the new player in oxygen-independent HIF-1alpha degradation.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
19442097-5	2009	The mitochondria function is regulated by several factors including nitric oxide, oxidative stress, mammalian target of rapamycin, ADP and P(i) availability, which result in a complex regulation of ATP production and oxygen consumption, but also superoxide generation.	Oxygen	217-223	mechanistic target of rapamycin kinase	Homo sapiens	100-129
19165496-2	2009	HIF-1alpha is the inducible subunit of HIF-1, but the underlying mechanisms by which RPE cells sense a decrease in oxygen concentration and transduce this signal to HIF-1alpha are largely unknown.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19245828-8	2009	Increased Abeta levels promoted the production of reactive oxygen species, which damage DNA and accelerate neurodegenerative events.	Oxygen	59-65	amyloid beta precursor protein	Homo sapiens	10-15
19351718-9	2009	Collectively, these findings demonstrate that copper delivery into the biosynthetic secretory pathway is regulated by oxygen availability in macrophages by a selective increase in copper transport involving ATP7A.	Oxygen	118-124	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	207-212
19358330-9	2009	FGFR2-Tg-ECs exposed to 1% oxygen exhibited enhanced phosphorylation of 416-Tyr-Src, 473-Ser-Akt, and HIF1alpha accumulation.	Oxygen	27-33	thymoma viral proto-oncogene 1	Mus musculus	93-96
19468264-7	2009	Oxygen uptake decreased significantly after hormone replacement (24.1+/-6.3 vs 17.1+/-4.2 ml x kg x min(-1); p=0.03).Minute ventilation also showed an enhanced performance in treated patients (28.0+/-8.1 vs 23.5+/-5.6 l x min(-1); p=0.03), as did the heart rate (128+/-17 vs 121+/-17 bpm; p=0.03).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	100-106
19468264-7	2009	Oxygen uptake decreased significantly after hormone replacement (24.1+/-6.3 vs 17.1+/-4.2 ml x kg x min(-1); p=0.03).Minute ventilation also showed an enhanced performance in treated patients (28.0+/-8.1 vs 23.5+/-5.6 l x min(-1); p=0.03), as did the heart rate (128+/-17 vs 121+/-17 bpm; p=0.03).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	222-228
19232736-8	2009	EXAFS studies on C-424 CBS are consistent with the presence of two axial N/O low Z scatters with only one being a rigid unit of a histidine residue while the other could be a solvent molecule, an oxygen atom from the peptide backbone or a side chain nitrogen.	Oxygen	196-202	cystathionine beta-synthase	Homo sapiens	23-26
19232363-2	2009	We previously reported that soluble (s) forms of EphB4 and ephrinB2 significantly reduced retinal NV in a model of oxygen-induced retinopathy.	Oxygen	115-121	ephrin B2	Homo sapiens	59-67
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-68
18841468-1	2009	The NO donor 3-Morpholinosydnonimine (SIN-1) releases NO in the presence of molecular oxygen.	Oxygen	86-92	MAPK associated protein 1	Homo sapiens	38-43
18841468-4	2009	The mean oxygen consumption by synaptosomal mitochondria was approximately 3.8 nmol of O(2) min(-1) mg(-1) protein, which decreased significantly in the presence of SIN-1 1 mM to 2.5 nmol O(2) min(-1) mg(-1).	Oxygen	9-15	MAPK associated protein 1	Homo sapiens	165-170
18841468-4	2009	The mean oxygen consumption by synaptosomal mitochondria was approximately 3.8 nmol of O(2) min(-1) mg(-1) protein, which decreased significantly in the presence of SIN-1 1 mM to 2.5 nmol O(2) min(-1) mg(-1).	Oxygen	87-91	MAPK associated protein 1	Homo sapiens	165-170
19723471-4	2009	For luciferase-based reporters, we hypothesized that the oxygen-dependent destruction domain (ODD) from hypoxia-inducible factor 1 alpha (HIF-1 alpha) may provide improved sensitivity over luciferase-ODC, owing to its extremely rapid turnover by the proteasome (HIF-1 alpha has a half-life of less than 5 minutes).	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-136
19723471-4	2009	For luciferase-based reporters, we hypothesized that the oxygen-dependent destruction domain (ODD) from hypoxia-inducible factor 1 alpha (HIF-1 alpha) may provide improved sensitivity over luciferase-ODC, owing to its extremely rapid turnover by the proteasome (HIF-1 alpha has a half-life of less than 5 minutes).	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-149
19723471-4	2009	For luciferase-based reporters, we hypothesized that the oxygen-dependent destruction domain (ODD) from hypoxia-inducible factor 1 alpha (HIF-1 alpha) may provide improved sensitivity over luciferase-ODC, owing to its extremely rapid turnover by the proteasome (HIF-1 alpha has a half-life of less than 5 minutes).	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	262-273
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
19384570-8	2009	Finally, exposure to hyperbaric oxygen (HBO) also stabilized HIF-1alpha in hmNPCs and induced neurogenesis in vitro.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
19461873-5	2009	HIF-1 is a transcription factor complex that plays key roles in oxygen homeostasis, tumor formation, glucose metabolism, cell survival, and inflammatory response.	Oxygen	64-70	Hypoxia-inducible factor 1	Caenorhabditis elegans	0-5
19220812-4	2009	In addition, low oxygen concentrations induced the active export of COMMD1 from the nucleus in a CRM1-dependent manner.	Oxygen	17-23	copper metabolism domain containing 1	Homo sapiens	68-74
19385054-6	2009	Because oxygen plays a fundamental key role in our life and oxidative stress is implicated in a wide variety of human diseases, catalase delivery could have wide application in the near future.	Oxygen	8-14	catalase	Homo sapiens	128-136
19390832-0	2009	Backbone resonance assignment of a proteolysis-resistant fragment in the oxygen-dependent degradation domain of the hypoxia inducible factor 1alpha.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-147
19390832-1	2009	Hypoxia-inducible factor 1alpha (HIF1alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
19390832-1	2009	Hypoxia-inducible factor 1alpha (HIF1alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
19390832-1	2009	Hypoxia-inducible factor 1alpha (HIF1alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
19390832-1	2009	Hypoxia-inducible factor 1alpha (HIF1alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
19390832-2	2009	The oxygen-dependent degradation (ODD) domain of HIF1alpha responsible for the negative regulation of HIF1alpha in normoxia is intrinsically unfolded.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-58
19390832-2	2009	The oxygen-dependent degradation (ODD) domain of HIF1alpha responsible for the negative regulation of HIF1alpha in normoxia is intrinsically unfolded.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-111
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
19251694-11	2009	SEPT9_v1 also protected HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
19251694-11	2009	SEPT9_v1 also protected HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-123
19251694-12	2009	In conclusion, a new mechanism of oxygen-independent activation of HIF-1 has been identified that is mediated by SEPT9_v1 blockade of RACK1 activity on HIF-1alpha degradation.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
19251694-12	2009	In conclusion, a new mechanism of oxygen-independent activation of HIF-1 has been identified that is mediated by SEPT9_v1 blockade of RACK1 activity on HIF-1alpha degradation.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
19204000-3	2009	HIF-1 is a transcription factor that is responsive to oxygen.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
19262507-6	2009	The soluble guanylate cyclase GCY-35 is required for high oxygen to activate the neurons; GLB-5 provides inhibitory input when oxygen decreases below 21%.	Oxygen	58-64	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	30-36
18942756-3	2009	This study tested the hypothesis that pre- or post-treatment of cultured cortical astrocytes with sulforaphane, an alkylating agent known to activate the NRF2 pathway of gene expression protects against death of astrocytes caused by transient exposure to O(2) and glucose deprivation (OGD).	Oxygen	255-259	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-158
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-129
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	226-236
19317484-0	2009	Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase.	Oxygen	23-25	cytochrome c, somatic	Homo sapiens	29-41
19278337-6	2009	Expression of APRIL and antiviral antibodies of IgA and IgM but not IgG isotype predicted better oxygen saturation.	Oxygen	97-103	TNF superfamily member 13	Homo sapiens	14-19
19317484-0	2009	Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase.	Oxygen	23-25	cytochrome c, somatic	Homo sapiens	69-81
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Oxygen	68-74	cytochrome c, somatic	Homo sapiens	0-12
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Oxygen	68-74	cytochrome c, somatic	Homo sapiens	112-124
19317484-1	2009	Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons.	Oxygen	68-74	cytochrome c, somatic	Homo sapiens	126-130
19317484-4	2009	The current paper shows that the same functional CcO model catalyzes the four-electron reduction of O(2) using the actual biological reductant Cytc in a homogeneous solution.	Oxygen	100-104	cytochrome c, somatic	Homo sapiens	143-147
20157526-5	2009	We further show that cells derived from Atg7(-/-) mice have an altered metabolic profile characterized by decreased resting mitochondrial oxygen consumption and a compensatory increase in basal glycolytic rates.	Oxygen	138-144	autophagy related 7	Mus musculus	40-44
19348778-1	2009	The kinetics of the glucose oxidase-catalyzed reaction of glucose with O2, which produces gluconic acid and hydrogen peroxide, and the catalase-assisted breakdown of hydrogen peroxide to generate oxygen, have been measured via the rate of O2 depletion or production.	Oxygen	196-202	catalase	Homo sapiens	135-143
19348778-1	2009	The kinetics of the glucose oxidase-catalyzed reaction of glucose with O2, which produces gluconic acid and hydrogen peroxide, and the catalase-assisted breakdown of hydrogen peroxide to generate oxygen, have been measured via the rate of O2 depletion or production.	Oxygen	239-241	catalase	Homo sapiens	135-143
19348778-4	2009	The two reactions were combined in a single experiment: addition of glucose oxidase to glucose-rich cell-free media caused a rapid drop in [O2], and subsequent addition of catalase caused [O2] to rise and then decrease to zero.	Oxygen	189-191	catalase	Homo sapiens	172-180
19208626-6	2009	Under hypoxic conditions, this inherently oxygen-dependent modification is arrested, thereby stabilizing HIF-alpha and allowing it to activate the EPO gene.	Oxygen	42-48	erythropoietin	Homo sapiens	147-150
18394828-8	2009	Supplementation with fibroblast growth factor 2 did not affect cell numbers but increased (P&lt;0.02) IFNT concentrations for blastocysts cultured in 5% oxygen but not those cultured in 20% oxygen.	Oxygen	153-159	fibroblast growth factor 2	Bos taurus	21-47
18394828-8	2009	Supplementation with fibroblast growth factor 2 did not affect cell numbers but increased (P&lt;0.02) IFNT concentrations for blastocysts cultured in 5% oxygen but not those cultured in 20% oxygen.	Oxygen	190-196	fibroblast growth factor 2	Bos taurus	21-47
19359588-3	2009	Forced expression of mutant IDH1 in cultured cells reduces formation of the enzyme product, alpha-ketoglutarate (alpha-KG), and increases the levels of hypoxia-inducible factor subunit HIF-1alpha, a transcription factor that facilitates tumor growth when oxygen is low and whose stability is regulated by alpha-KG.	Oxygen	255-261	hypoxia inducible factor 1 subunit alpha	Homo sapiens	185-195
19317484-5	2009	Both single and steady-state turnover kinetics studies indicate that O(2) binding is rate-determining and that O-O bond cleavage and electron transfer from reduced Cytc to the oxidized model complex are relatively fast.	Oxygen	69-73	cytochrome c, somatic	Homo sapiens	164-168
19341914-5	2009	Another recent novel approach is the assembling of hemoglobin and fibrinogen into a soluble nanodimension polyhemoglobin-fibrinogen complex that acts as an oxygen carrier with platelet-like activity.	Oxygen	156-162	fibrinogen beta chain	Homo sapiens	66-76
19290865-0	2009	Density functional theory (DFT) and combined quantum mechanical/molecular mechanics (QM/MM) studies on the oxygen activation step in nitric oxide synthase enzymes.	Oxygen	107-113	nitric oxide synthase 2	Homo sapiens	133-154
19341914-5	2009	Another recent novel approach is the assembling of hemoglobin and fibrinogen into a soluble nanodimension polyhemoglobin-fibrinogen complex that acts as an oxygen carrier with platelet-like activity.	Oxygen	156-162	fibrinogen beta chain	Homo sapiens	121-131
19213794-6	2009	A significant correlation was found between CRP levels, time spent at night with arterial oxygen saturation &lt;90% and ODI.	Oxygen	90-96	C-reactive protein	Homo sapiens	44-47
19095742-9	2009	Interestingly, also human islets subjected to prolactin treatment before experimental transplantation demonstrated improved revascularization, blood perfusion, and oxygen tension when evaluated 1 month after transplantation.	Oxygen	164-170	prolactin	Homo sapiens	46-55
19299711-6	2009	CD4(+)CD25(+) regulatory T cells suppress N-alpha-syn microglial-induced reactive oxygen species and NF-kappaB activation by modulating redox-active enzymes, cell migration, phagocytosis, and bioenergetic protein expression and cell function.	Oxygen	82-88	CD4 molecule	Homo sapiens	0-3
19165176-2	2009	It is a classic example of a hypoxia-inducible gene, and studies of the induction of EPO synthesis by low oxygen led to the discovery of a widespread system of hypoxia-inducible transcription factors.	Oxygen	106-112	erythropoietin	Homo sapiens	85-88
19278426-5	2009	RESULTS: LI fibroblasts showing a reduction of fibronectin expression evidenced a strong inhibition of oxygen consumption, a dramatic drop in the mitochondrial membrane potential (Delta psi(m)), and a higher apoptotic index.	Oxygen	103-109	fibronectin 1	Homo sapiens	47-58
18941752-4	2009	In the model, low tissue oxygen levels alter the internal dynamics of normal cells, causing them to release vascular endothelial growth factor (VEGF), which stimulates angiogenic sprouting.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	108-142
18941752-4	2009	In the model, low tissue oxygen levels alter the internal dynamics of normal cells, causing them to release vascular endothelial growth factor (VEGF), which stimulates angiogenic sprouting.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	144-148
19296479-5	2009	Also, higher order structures of hemoglobin-based oxygen carriers (HBOCs) and their interactions with human haptoglobin were analyzed.	Oxygen	50-56	haptoglobin	Homo sapiens	108-119
19364912-0	2009	Regulation of oxygen homeostasis by hypoxia-inducible factor 1.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-62
19176720-3	2009	The Arabidopsis (Arabidopsis thaliana) NAC domain-containing gene ANAC102 was shown to be induced under 0.1% oxygen within 30 min in both roots and shoots as well as in 0.1% oxygen-treated germinating seeds.	Oxygen	109-115	NAC domain containing protein 102	Arabidopsis thaliana	66-73
19176720-3	2009	The Arabidopsis (Arabidopsis thaliana) NAC domain-containing gene ANAC102 was shown to be induced under 0.1% oxygen within 30 min in both roots and shoots as well as in 0.1% oxygen-treated germinating seeds.	Oxygen	174-180	NAC domain containing protein 102	Arabidopsis thaliana	66-73
19176720-4	2009	Overexpression of ANAC102 altered the expression of a number of genes, including many previously identified as being low-oxygen responsive.	Oxygen	121-127	NAC domain containing protein 102	Arabidopsis thaliana	18-25
19176720-5	2009	Decreasing ANAC102 expression had no effect on global gene transcription in plants but did alter expression patterns in low-oxygen-stressed seeds.	Oxygen	124-130	NAC domain containing protein 102	Arabidopsis thaliana	11-18
19176720-7	2009	Decreased ANAC102 expression significantly decreased germination efficiency following a 0.1% oxygen treatment, but increased expression had no effect on germination.	Oxygen	93-99	NAC domain containing protein 102	Arabidopsis thaliana	10-17
19176720-8	2009	This protective role during germination appeared to be specific to low-oxygen stress, implicating ANAC102 as an important regulator of seed germination under flooding.	Oxygen	71-77	NAC domain containing protein 102	Arabidopsis thaliana	98-105
19176720-0	2009	The low-oxygen-induced NAC domain transcription factor ANAC102 affects viability of Arabidopsis seeds following low-oxygen treatment.	Oxygen	8-14	NAC domain containing protein 102	Arabidopsis thaliana	55-62
19176720-0	2009	The low-oxygen-induced NAC domain transcription factor ANAC102 affects viability of Arabidopsis seeds following low-oxygen treatment.	Oxygen	116-122	NAC domain containing protein 102	Arabidopsis thaliana	55-62
19364912-2	2009	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19364912-2	2009	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19221500-2	2009	Here we demonstrate that in response to limited oxygen conditions PTEN and p53 work in tandem to induce maspin in glioblastoma cells.	Oxygen	48-54	phosphatase and tensin homolog	Mus musculus	66-70
19586893-1	2009	The inducible nitric-oxide synthase (iNOS) can be induced by hypoxia to produce NO, which regulates blood flow and improves oxygen delivery to tissues.	Oxygen	124-130	nitric oxide synthase 2	Gallus gallus	4-35
19586893-1	2009	The inducible nitric-oxide synthase (iNOS) can be induced by hypoxia to produce NO, which regulates blood flow and improves oxygen delivery to tissues.	Oxygen	124-130	nitric oxide synthase 2	Gallus gallus	37-41
19445326-5	2009	Three scenarios were simulated, and the results confirmed that sediment oxygen demand (SOD) is the governing factor controlling a dissolved oxygen decrease in the system.	Oxygen	72-78	superoxide dismutase 1	Homo sapiens	87-90
19445326-5	2009	Three scenarios were simulated, and the results confirmed that sediment oxygen demand (SOD) is the governing factor controlling a dissolved oxygen decrease in the system.	Oxygen	140-146	superoxide dismutase 1	Homo sapiens	87-90
19221500-8	2009	The integration of PTEN and p53 into a common pathway for the induction of another tumor suppressor, Maspin, constitutes a tumor suppressor network of PTEN/p53/Mapsin that is operational under limited oxygen conditions.	Oxygen	201-207	phosphatase and tensin homolog	Mus musculus	19-23
19221500-8	2009	The integration of PTEN and p53 into a common pathway for the induction of another tumor suppressor, Maspin, constitutes a tumor suppressor network of PTEN/p53/Mapsin that is operational under limited oxygen conditions.	Oxygen	201-207	phosphatase and tensin homolog	Mus musculus	151-155
19260015-0	2009	Erythropoietin and the skin: a role for epidermal oxygen sensing?	Oxygen	50-56	erythropoietin	Homo sapiens	0-14
19374861-1	2009	Current study was attempted to assess whether hyperbaric oxygen pretreatment or treatment exerts its antipyresis by reducing circulating interleukin-6 and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) in rabbits.	Oxygen	57-63	interleukin-6	Oryctolagus cuniculus	137-150
19267931-8	2009	Gene silencing of p21 and p27 promoted DNA synthesis at ambient oxygen concentrations.	Oxygen	64-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-21
18776134-8	2009	In addition, IL-6 Tg(+) mice exposed to 100% oxygen exhibited reduced ASK-1 levels and enhanced SOCS-1 expression compared with wild-type mice.	Oxygen	45-51	interleukin 6	Mus musculus	13-17
19238291-8	2009	This disease causes decreased oxygen delivery to the heart resulting in tissue death and the release of cardiac myoglobin into the bloodstream.	Oxygen	30-36	myoglobin	Equus caballus	112-121
19374861-4	2009	Pretreatment or treatment with hyperbaric oxygen significantly reduced the lipopolysaccharide-induced overproduction of circulating interleukin-6, and hypothalamic glutamate, prostaglandin E(2), and hydroxyl radicals.	Oxygen	42-48	interleukin-6	Oryctolagus cuniculus	132-145
19374861-5	2009	The febrile response caused by central administration of interleukin-6 could also be suppressed by hyperbaric oxygen pretreatment or treatment.	Oxygen	110-116	interleukin-6	Oryctolagus cuniculus	57-70
19374861-7	2009	These results indicate that hyperbaric oxygen pretreatment or treatment may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-prostaglandin-E(2) pathways in the hypothalamus and circulating interleukin-6 accumulation during lipopolysaccharide-fever.	Oxygen	39-45	interleukin-6	Oryctolagus cuniculus	208-221
19138154-5	2009	On the basis of isotope labeling studies using a residual gas analyzer, the mechanism is determined to be formation of O=FeIV(Por)*+ (Compound I) from oxygen atom transfer, and subsequent rebound with the resulting hypochlorite ion (ClO-) to give dioxygen and chloride.	Oxygen	151-157	cytochrome p450 oxidoreductase	Homo sapiens	126-129
19138154-5	2009	On the basis of isotope labeling studies using a residual gas analyzer, the mechanism is determined to be formation of O=FeIV(Por)*+ (Compound I) from oxygen atom transfer, and subsequent rebound with the resulting hypochlorite ion (ClO-) to give dioxygen and chloride.	Oxygen	247-255	cytochrome p450 oxidoreductase	Homo sapiens	126-129
19318315-0	2009	Low O2 concentrations enhance the positive effect of IL-17 on the maintenance of erythroid progenitors during co-culture of CD34+ and mesenchymal stem cells.	Oxygen	4-6	CD34 molecule	Homo sapiens	124-128
19002703-2	2009	Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen.	Oxygen	235-241	vascular cell adhesion molecule 1	Homo sapiens	0-33
19002703-2	2009	Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen.	Oxygen	235-241	vascular cell adhesion molecule 1	Homo sapiens	35-41
19318315-5	2009	In addition, the stimulation of IL-6 production by IL-17 in MSC cultures and co-cultures is enhanced by low O2 concentration.	Oxygen	108-110	interleukin 6	Homo sapiens	32-36
19318315-6	2009	The expression of some differentiation markers (CD34, CD13 and CD41) on haematopoietic cells in co-cultures also depends upon the oxygen concentration.	Oxygen	130-136	CD34 molecule	Homo sapiens	48-52
19023330-4	2009	We also show that loss of HtrA2 results in the accumulation of unfolded proteins in the mitochondria, defective mitochondrial respiration and enhanced production of reactive oxygen species that contribute to the induction of CHOP expression and to neuronal cell death.	Oxygen	174-180	DNA damage inducible transcript 3	Homo sapiens	225-229
19171477-2	2009	The discovery that the hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular response to low oxygen led to the concept that inhibiting HIF-1 activity may sensitise hypoxic cancer cells to radiation and cytotoxic drugs.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-49
19171477-2	2009	The discovery that the hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular response to low oxygen led to the concept that inhibiting HIF-1 activity may sensitise hypoxic cancer cells to radiation and cytotoxic drugs.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-56
19010979-6	2009	Oxygen transfer capacity averaged 41.7+/-20.8 mL x min(-1), carbon dioxide removal was 148.0+/-63.4 mL x min(-1).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	51-57
19135258-5	2009	The catalase like activity was tested using a Clark-type oxygen electrode.	Oxygen	57-63	catalase	Homo sapiens	4-12
18339380-11	2009	CONCLUSION(S): PARP-2 may have a role in prevention of oxygen species/oxidative stress and chemical (staurosporine)-induced sperm cell apoptosis.	Oxygen	55-61	poly(ADP-ribose) polymerase 2	Homo sapiens	15-21
19016245-4	2009	Prolonged exposure to 1% O(2) caused barrier breakdown and exposure to 0.1% O(2) dramatically accelerated disruption and induced cell death, mediated at least in part via caspase-3 activation.	Oxygen	76-80	caspase 3	Homo sapiens	171-180
18787531-7	2009	Furthermore, inhibition of IFNgamma signaling and downregulation of IFNgammaR1 was also mediated by nonmetal-binding hypoxia mimetics and reduced oxygen tensions.	Oxygen	146-152	interferon gamma	Homo sapiens	27-35
19212630-2	2009	A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-120
19234213-0	2009	Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor.	Oxygen	11-17	interferon gamma	Mus musculus	92-101
24150558-11	2009	Key pointsIn sports training athletes engaged in the same training regimen acquired different stages of cardiac hypertrophy.Physical exercise had a significant effect on serum insulin-like growth factor - I concentration depending on maximal oxygen uptake during endurance exercise.Athletes with clinically diagnosed physiological left ventricular hypertrophy had higher resting serum insulin-like growth factor - I concentration compared to those without left ventricular hypertrophy and sedentary subjects.Increased insulin-like growth factor - I release during long-term training seems to significantly contribute to sports-specific functional adaptation of the left ventricle.	Oxygen	242-248	insulin like growth factor 1	Homo sapiens	176-206
19118564-4	2009	If the oxygen supply is insufficient, the resulting hypoxia stimulates angiogenesis through upregulation of HIF-1 alpha and VEGF.	Oxygen	7-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-119
19118564-4	2009	If the oxygen supply is insufficient, the resulting hypoxia stimulates angiogenesis through upregulation of HIF-1 alpha and VEGF.	Oxygen	7-13	vascular endothelial growth factor A	Homo sapiens	124-128
19175415-4	2009	The gene expressions of both the important transcription factors Hap1 and Rox1, involved in oxygen sensing, were mainly increased in the first 3 h, while YAP1 expression, which is involved in the oxidative stress response, increased drastically only in the first 45 min.	Oxygen	92-98	Rox1p	Saccharomyces cerevisiae S288C	74-78
19082545-6	2009	The consumption of oxygen induced by 250 microM SIN-1 was found to be decreased in the presence of high concentrations of LA (400-1,600 microM), indicating that LA at these concentrations may affect the generation of peroxynitrite from auto-oxidation of SIN-1.	Oxygen	19-25	MAPK associated protein 1	Homo sapiens	48-53
19082545-6	2009	The consumption of oxygen induced by 250 microM SIN-1 was found to be decreased in the presence of high concentrations of LA (400-1,600 microM), indicating that LA at these concentrations may affect the generation of peroxynitrite from auto-oxidation of SIN-1.	Oxygen	19-25	MAPK associated protein 1	Homo sapiens	254-259
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	BCL2 apoptosis regulator	Homo sapiens	161-166
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	199-215
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	myeloperoxidase	Homo sapiens	236-251
19205055-5	2009	Multivariate linear regressions demonstrated that MMP-9 levels and MMP-9/TIMP-1 ratios in the cord blood of the premature infants correlated with the oxygen supplementation period (r = 0.58, P = 0.003 and r = 0.41, P = 0.030, respectively).	Oxygen	150-156	TIMP metallopeptidase inhibitor 1	Homo sapiens	73-79
19095301-5	2009	We have recently reported on the expression and function of two Bcl-2 family members in normal placental development, namely the pro-apoptotic Mtd/Bok, and its anti-apoptotic partner Mcl-1 and have found that their expression is upregulated by low oxygen, a key mediator of trophoblast cell proliferation in early placentation.	Oxygen	248-254	BCL2 apoptosis regulator	Homo sapiens	64-69
19255003-13	2009	CONCLUSIONS: Vascular endothelial growth factor concentrations of &gt;140 pg/mL may indicate insufficient oxygen delivery to tissues and may serve as a marker of the need for transfusion or of tissue hypoxia in other diseases.	Oxygen	106-112	vascular endothelial growth factor A	Homo sapiens	13-47
19095301-5	2009	We have recently reported on the expression and function of two Bcl-2 family members in normal placental development, namely the pro-apoptotic Mtd/Bok, and its anti-apoptotic partner Mcl-1 and have found that their expression is upregulated by low oxygen, a key mediator of trophoblast cell proliferation in early placentation.	Oxygen	248-254	BCL2 family apoptosis regulator BOK	Homo sapiens	147-150
18777130-7	2009	From the results of stepwise multiple linear regression analysis, the lowest oxygen saturation was a significant determinant of FMD (beta = 0.25, p &lt; 0.01, adjusted R (2) = 6%), and BMI (beta = 0.22, p &lt; 0.05) and waist-to-hip ratio (beta = 0.21, p &lt; 0.05) were significant variables to explain CRP (adjusted R (2) = 11%, p &lt; 0.01) in the middle aged patients.	Oxygen	77-83	C-reactive protein	Homo sapiens	304-307
19164785-12	2009	CONCLUSIONS: These results suggest that nuclear factor kappa B-dependent NCX1 upregulation may play a fundamental role in Ca(2+) refilling in the endoplasmic reticulum, thus helping neurons to prevent endoplasmic reticulum stress during oxygen and glucose deprivation.	Oxygen	237-243	solute carrier family 8 member A1	Homo sapiens	73-77
19335985-5	2009	RESULTS: Western blot analysis showed that both HIF-1 alpha and HSP70-2 proteins were strongly increased after HCC cells were exposed to hypoxic conditions (1% O2) for 6 h, and the expression level of HSP70-2 was increased in a time-dependent manner.	Oxygen	160-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-59
19218147-4	2009	Akt activation is regulated by growth factors, insulin, and also environmental factors as altered oxygen tension and high temperature.	Oxygen	98-104	AKT serine/threonine kinase 1	Homo sapiens	0-3
19041937-10	2009	These findings suggest that TNF alters the cellular redox state, reduces the expression of four complex I subunits by increasing mitochondrial O(2)(*)(-) production and depleting ATP synthesis, and decreases oxygen consumption, thereby resulting in mitochondrial damage and leading to LV dysfunction.	Oxygen	208-214	tumor necrosis factor	Rattus norvegicus	28-31
19098000-8	2009	All of these results indicate that Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor.	Oxygen	230-236	AKT serine/threonine kinase 1	Homo sapiens	35-38
19098000-8	2009	All of these results indicate that Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor.	Oxygen	230-236	mechanistic target of rapamycin kinase	Homo sapiens	39-43
19098000-8	2009	All of these results indicate that Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
19098000-8	2009	All of these results indicate that Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
19187779-0	2009	Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.	Oxygen	38-44	BHLH domain-containing protein	Caenorhabditis elegans	18-23
19179292-0	2009	PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.	Oxygen	90-96	PPARG coactivator 1 alpha	Homo sapiens	0-10
19179292-0	2009	PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
19179292-5	2009	PGC-1alpha-dependent induction of HIF target genes under physiologic oxygen concentrations is not through transcriptional coactivation of HIF or up-regulation of HIF-1alpha mRNA but through HIF-1alpha protein stabilization.	Oxygen	69-75	PPARG coactivator 1 alpha	Homo sapiens	0-10
19179292-7	2009	Thus, we propose that at physiologic oxygen concentrations, PGC-1alpha is coupled to HIF signaling through the regulation of intracellular oxygen availability, allowing cells and tissues to match increased oxygen demand after mitochondrial biogenesis with increased oxygen supply.	Oxygen	37-43	PPARG coactivator 1 alpha	Homo sapiens	60-70
19179292-7	2009	Thus, we propose that at physiologic oxygen concentrations, PGC-1alpha is coupled to HIF signaling through the regulation of intracellular oxygen availability, allowing cells and tissues to match increased oxygen demand after mitochondrial biogenesis with increased oxygen supply.	Oxygen	139-145	PPARG coactivator 1 alpha	Homo sapiens	60-70
19179292-7	2009	Thus, we propose that at physiologic oxygen concentrations, PGC-1alpha is coupled to HIF signaling through the regulation of intracellular oxygen availability, allowing cells and tissues to match increased oxygen demand after mitochondrial biogenesis with increased oxygen supply.	Oxygen	139-145	PPARG coactivator 1 alpha	Homo sapiens	60-70
19179292-7	2009	Thus, we propose that at physiologic oxygen concentrations, PGC-1alpha is coupled to HIF signaling through the regulation of intracellular oxygen availability, allowing cells and tissues to match increased oxygen demand after mitochondrial biogenesis with increased oxygen supply.	Oxygen	139-145	PPARG coactivator 1 alpha	Homo sapiens	60-70
19187779-2	2009	Using Caenorhabditis elegans we found extended oxygen deprivation resulted in activation of SBP-1, the worm homologue of SREBP1, a transcription factor important in maintaining lipid homeostasis.	Oxygen	47-53	BHLH domain-containing protein	Caenorhabditis elegans	92-97
18392771-4	2009	Regression analysis showed that decreases in Tf were simultaneously correlated with the plasma lipid pattern (in particular with decreasing cholesterol and increasing triglycerides), with decreases in albumin and peripheral O2 extraction, and with increasing cardiac index (p &lt; 0.001 for all).	Oxygen	224-226	transferrin	Homo sapiens	45-47
19204295-4	2009	administration of ITPP (0.5-3 g/kg) caused a dose-related increase in the oxygen tension at which Hb is 50% saturated (p50), with a maximal increase of 31%.	Oxygen	74-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-122
19128155-5	2009	The two terminal Co(II) ions contain a facial coordination environment (3N, 3O) comprising three imino nitrogen atoms and three phenolate oxygen atoms.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19133788-1	2009	We use quantum mechanics to elucidate the mechanism for the reaction of molecular oxygen with palladium-hydride complexes, (pyridine)(2)-Pd(II)(H)OAc, in toluene, focusing specifically on the direct insertion pathway of dioxygen into the Pd-H bond and pathways proceeding through a Pd(0) intermediate for both cis and trans starting configurations as well as with the assistance of an extra HOAc molecule We report the potential energy surfaces and structures for each of these pathways.	Oxygen	82-88	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	238-242
18990675-9	2009	Oxygen desaturation greater than 4.6% was associated with a 1.5-fold increase in insulin resistance, according to the homeostasis model assessment index.	Oxygen	0-6	insulin	Homo sapiens	81-88
19143641-1	2009	mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell.	Oxygen	101-107	mechanistic target of rapamycin kinase	Homo sapiens	0-4
19143641-1	2009	mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell.	Oxygen	101-107	mechanistic target of rapamycin kinase	Homo sapiens	6-35
18793248-1	2009	BACKGROUND: High oxygen-affinity haemoglobin variants and 2,3-diphosphoglycerate (2,3-DPG) deficiency are inherited diseases generating low tissue oxygen tension and erythropoietin-driven erythrocytosis, that characterizes the clinical phenotype of patients.	Oxygen	17-23	erythropoietin	Homo sapiens	166-180
19143764-7	2009	When cultured at 5% oxygen for either 4 weeks or up to 18 months, high levels of Nanog and Notch1 transcriptional expression were detected, albeit the expression was significantly lower during longer exposure.	Oxygen	20-26	notch receptor 1	Homo sapiens	91-97
19143764-9	2009	Looking into the molecular mechanisms of the maintenance of self-renewal at low oxygen tensions, we found that inhibition of Notch signalling fully abrogated the hypoxic induction of undifferentiated phenotype.	Oxygen	80-86	notch receptor 1	Homo sapiens	125-130
19187775-7	2009	Furthermore, AceCS2(-/-) mice exhibited increased oxygen consumption and reduced weight gain on a low-carbohydrate diet.	Oxygen	50-56	acyl-CoA synthetase short-chain family member 1	Mus musculus	13-19
18607542-1	2009	Hypoxia-inducing factor-1 alpha (HIF-1alpha), is a major survival factor for tumor cells growing in a low oxygen environment.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
19169834-4	2009	Overall mean bias [95% confidence interval (CI)] of rate of uptake was 17.9 [7.3 to 28.5] ml min(-1) for oxygen, 0.04 [-0.42 to 0.50] ml min(-1) for sevoflurane, 10.9 [-16.1 to 37.8] for CO(2), and 8.8 [-14.8 to 32.4] ml min(-1) for nitrous oxide where present.	Oxygen	105-111	CD59 molecule (CD59 blood group)	Homo sapiens	93-99
18793248-2	2009	Level of blood p50 (the oxygen tension at which haemoglobin is 50% saturated) is used to recognize these conditions.	Oxygen	24-30	nuclear factor kappa B subunit 1	Homo sapiens	15-18
19143941-2	2009	The first followed from the detailed characterization of the regulation of expression of erythropoietin by oxygen and led to the discovery of the hypoxically regulated transcription factor, HIF (hypoxia-inducible factor).	Oxygen	107-113	erythropoietin	Homo sapiens	89-103
19007879-0	2009	Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
19123835-1	2009	The amyloid beta peptide (Abeta) of Alzheimer"s disease evolves hydrogen peroxide in vitro in the presence of Cu(II), external reducing agents, and molecular oxygen, without producing detectable amounts of the one-electron reduced intermediate, superoxide, O(2)(-*).	Oxygen	158-164	amyloid beta precursor protein	Homo sapiens	26-31
19158663-0	2009	Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.	Oxygen	0-6	Ett1p	Saccharomyces cerevisiae S288C	28-32
19158663-8	2009	In the presence of oxygen, Nro1 binding to Ofd1 is disrupted, leading to rapid degradation of Sre1N.	Oxygen	19-25	Ett1p	Saccharomyces cerevisiae S288C	27-31
19158663-9	2009	We conclude that the Ofd1 dioxygenase domain functions as an oxygen sensor that regulates binding of Nro1 to Ofd1 to control oxygen-dependent Sre1N stability.	Oxygen	28-34	Ett1p	Saccharomyces cerevisiae S288C	101-105
19158663-9	2009	We conclude that the Ofd1 dioxygenase domain functions as an oxygen sensor that regulates binding of Nro1 to Ofd1 to control oxygen-dependent Sre1N stability.	Oxygen	61-67	Ett1p	Saccharomyces cerevisiae S288C	101-105
18835277-4	2009	Mutations at M57 (M57L) and H210 (H210G, H210M, and H210N), both of which are involved in interactions with the C2 carbonyl oxygen in uracil or xanthine, cause substantial reductions in XDG and UDG activities.	Oxygen	124-130	uracil DNA glycosylase	Homo sapiens	194-197
18952043-5	2009	We demonstrated submicromolar affinities for 2-OG and ferrous iron and HIF-PHD2 Km values for oxygen that are greater than atmospheric oxygen levels, suggesting that molecular oxygen is indeed the key regulator of this pathway.	Oxygen	94-100	egl-9 family hypoxia inducible factor 1	Homo sapiens	75-79
18952043-5	2009	We demonstrated submicromolar affinities for 2-OG and ferrous iron and HIF-PHD2 Km values for oxygen that are greater than atmospheric oxygen levels, suggesting that molecular oxygen is indeed the key regulator of this pathway.	Oxygen	135-141	egl-9 family hypoxia inducible factor 1	Homo sapiens	75-79
18952043-5	2009	We demonstrated submicromolar affinities for 2-OG and ferrous iron and HIF-PHD2 Km values for oxygen that are greater than atmospheric oxygen levels, suggesting that molecular oxygen is indeed the key regulator of this pathway.	Oxygen	135-141	egl-9 family hypoxia inducible factor 1	Homo sapiens	75-79
19007879-1	2009	HIF1 (hypoxia-inducible factor 1 alpha) is considered a central oxygen-threshold sensor in mammalian cells.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-4
19007879-1	2009	HIF1 (hypoxia-inducible factor 1 alpha) is considered a central oxygen-threshold sensor in mammalian cells.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	6-38
19007879-2	2009	In the presence of oxygen, HIF1 is marked by prolyl hydroxylases (PHDs) at the oxygen-dependent degradation (ODD) domain for ubiquitination followed by rapid proteasomal degradation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-31
19007879-2	2009	In the presence of oxygen, HIF1 is marked by prolyl hydroxylases (PHDs) at the oxygen-dependent degradation (ODD) domain for ubiquitination followed by rapid proteasomal degradation.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-31
19007879-3	2009	However, the actual mechanisms of oxygen sensing by HIF1 are still controversial.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-56
19007879-4	2009	Thus, HIF1 expression correlates poorly with tissue oxygen levels, and PHDs are themselves target genes of HIF1 considered to readjust to new oxygen thresholds.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-111
19007879-9	2009	The rapid and complete degradation of HIF1 under enzymatic hypoxia suggests that, in addition to hypoxia sensing, the HIF1/PHD loop may also compensate for fluctuations of tissue oxygen staying tuned to other, e.g., metabolic, signals.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-42
19028555-5	2009	An AhR-activation by 10nM TCDD and HIF-1alpha activation by 5% oxygen induced activation of NFATc1.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
18616988-4	2009	Here we show that Clca1 expression is induced in cultured rat hippocampal neurons exposed to oxygen/glucose-free media; this induction is mediated by a signaling pathway activated by extrasynaptic NMDA receptors.	Oxygen	93-99	chloride channel accessory 1	Rattus norvegicus	18-23
19014992-7	2009	By utilizing both antioxidants or specific COX inhibitors, it was shown that COX-2 upregulation was dependent on ROS, specifically, O2(-).	Oxygen	132-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19072325-0	2009	First half-reaction mechanism of nitric oxide synthase: the role of proton and oxygen coupled electron transfer in the reaction by quantum mechanics/molecular mechanics.	Oxygen	79-85	nitric oxide synthase 2	Homo sapiens	33-54
19536501-8	2009	This time domain of O(2)-sensing in the brain involves gene expression under the control of hypoxia inducible factor-1+/- (HIF-1+/- and potentially several HIF-1+/- targets, such as erythropoietin, endothelin-1, heme oxygenase and tyrosine hydroxylase.	Oxygen	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-128
19536501-8	2009	This time domain of O(2)-sensing in the brain involves gene expression under the control of hypoxia inducible factor-1+/- (HIF-1+/- and potentially several HIF-1+/- targets, such as erythropoietin, endothelin-1, heme oxygenase and tyrosine hydroxylase.	Oxygen	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-161
19536481-2	2009	Ngb is concentrated in the mitochondria-containing areas of neurons, and its distribution is correlated with oxygen consumption rates.	Oxygen	109-115	neuroglobin	Rattus norvegicus	0-3
19536501-8	2009	This time domain of O(2)-sensing in the brain involves gene expression under the control of hypoxia inducible factor-1+/- (HIF-1+/- and potentially several HIF-1+/- targets, such as erythropoietin, endothelin-1, heme oxygenase and tyrosine hydroxylase.	Oxygen	20-24	erythropoietin	Homo sapiens	182-196
19536481-8	2009	Similar to hemoglobin, Ngb may act as a respiratory protein by reversibly binding gaseous ligands NO and O(2) and could act as a NO scavenger and participate in detoxification of Reactive Oxygen Species (ROS) generated under hypoxic conditions.	Oxygen	105-109	neuroglobin	Rattus norvegicus	23-26
19227455-0	2009	Carotid body sensory discharge and glomus cell HIF-1 alpha are regulated by a common oxygen sensor.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-58
19227455-3	2009	In this paper, we summarize evidence that both the acute changes in neural activity and the longer term adaptive changes linked to HIF-1 alpha induction share the same oxygen sensor, mitochondrial cytochrome c oxidase.	Oxygen	168-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-142
19536501-8	2009	This time domain of O(2)-sensing in the brain involves gene expression under the control of hypoxia inducible factor-1+/- (HIF-1+/- and potentially several HIF-1+/- targets, such as erythropoietin, endothelin-1, heme oxygenase and tyrosine hydroxylase.	Oxygen	20-24	endothelin 1	Homo sapiens	198-210
19227471-0	2009	Effects of proinsulin C-peptide on oxygen transport, uptake and utilization in insulinopenic diabetic subjects--a review.	Oxygen	35-41	insulin	Homo sapiens	11-21
19227471-0	2009	Effects of proinsulin C-peptide on oxygen transport, uptake and utilization in insulinopenic diabetic subjects--a review.	Oxygen	35-41	insulin	Homo sapiens	22-31
19052874-11	2009	Regulation of Fas and Bcl-2 may be regarded as protective measures of the cell in response to hyperbaric oxygen.	Oxygen	105-111	BCL2 apoptosis regulator	Homo sapiens	22-27
19227471-3	2009	C-peptide also improves diabetes-induced erythrocyte deformability, which likely improves oxygen availability and uptake in affected tissues.	Oxygen	90-96	insulin	Homo sapiens	0-9
19227471-5	2009	In the kidney, C-peptide normalizes the diabetes-induced increase in oxygen consumption via inhibition of the Na+/K+-ATPase.	Oxygen	69-75	insulin	Homo sapiens	15-24
20636072-3	2009	Among the classes of prohibited substances, three have given rise to the most recent analytical developments in the field: anabolic agents; peptide and protein hormones; and methods to increase oxygen delivery to the tissues, including recombinant erythropoietin.	Oxygen	194-200	erythropoietin	Homo sapiens	248-262
19827678-10	2009	The mitochondrial isoenzymes of catalase, glutation peroxidase, and thioredoxin reductase convert hydrogen peroxide into molecular oxygen and form high local oxygen concentration as the major factor for the cytochrome oxidase activity.	Oxygen	131-137	catalase	Homo sapiens	32-40
19827678-10	2009	The mitochondrial isoenzymes of catalase, glutation peroxidase, and thioredoxin reductase convert hydrogen peroxide into molecular oxygen and form high local oxygen concentration as the major factor for the cytochrome oxidase activity.	Oxygen	158-164	catalase	Homo sapiens	32-40
18992855-1	2009	Laser flash photolysis technique was used to study zinc and cadmium ion effects on bimolecular and nanosecond geminate molecular oxygen (O(2)) rebinding to horse heart myoglobin.	Oxygen	129-135	myoglobin	Equus caballus	168-177
19229698-2	2009	A nanobiotechnology-based polyhemogloin-calatase-superoxide dismutase can prevent this because the oxygen carrier, polyhemoglobin, is linked to antioxidant enzymes, catalase and superoxide dismutase.	Oxygen	99-105	catalase	Homo sapiens	165-173
18992855-1	2009	Laser flash photolysis technique was used to study zinc and cadmium ion effects on bimolecular and nanosecond geminate molecular oxygen (O(2)) rebinding to horse heart myoglobin.	Oxygen	137-141	myoglobin	Equus caballus	168-177
18992855-4	2009	The study revealed that modulation of the myoglobin affinity for O(2) by zinc and cadmium occurs at the level of the innermost barrier controlling O(2) rebinding from within the primary docking site.	Oxygen	65-69	myoglobin	Equus caballus	42-51
18992855-4	2009	The study revealed that modulation of the myoglobin affinity for O(2) by zinc and cadmium occurs at the level of the innermost barrier controlling O(2) rebinding from within the primary docking site.	Oxygen	147-151	myoglobin	Equus caballus	42-51
19591694-1	2009	INTRODUCTION: Infusing arginine vasopressin (AVP) in vasodilatory shock usually decreases cardiac output and thus systemic oxygen transport.	Oxygen	123-129	vasopressin	Sus scrofa	32-43
18365198-8	2009	These results indicate that Her2 blockade can improve tumor oxygenation by decreasing oxygen consumption (reducing tumor cell proliferation and inducing necrosis) and increasing oxygen delivery (vascular density and architecture).	Oxygen	60-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32
18365198-8	2009	These results indicate that Her2 blockade can improve tumor oxygenation by decreasing oxygen consumption (reducing tumor cell proliferation and inducing necrosis) and increasing oxygen delivery (vascular density and architecture).	Oxygen	86-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32
20037203-2	2009	The C1772T (P582S) and G1790A (A588T) polymorphisms, within the oxygen dependent degradation domain of HIF-1alpha protein, seem to be important in the oxygen regulation of protein stability, influencing the progression of some hypoxic solid tumors.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
20037203-2	2009	The C1772T (P582S) and G1790A (A588T) polymorphisms, within the oxygen dependent degradation domain of HIF-1alpha protein, seem to be important in the oxygen regulation of protein stability, influencing the progression of some hypoxic solid tumors.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
19718265-3	2009	The authors present a case report where a free latissimus dorsi flap with subsequent hyperbaric oxygen therapy allowed a successful single stage reconstruction of this complex severely contaminated defect.	Oxygen	96-102	arachidonate 5-lipoxygenase activating protein	Homo sapiens	64-68
19863760-5	2009	beta1 blockade improves cardiovascular homeostasis in septic animals, by lowering myocardial oxygen consumption without altering organ perfusion, and perhaps by restoring normal cardiovascular variability.	Oxygen	93-99	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-5
19671044-1	2009	The hypoxia-inducible factor-1 (HIF-1) is a key regulator in the mammalian response to oxygen deficiency under both physiological and pathological conditions such as cancer.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
19671044-1	2009	The hypoxia-inducible factor-1 (HIF-1) is a key regulator in the mammalian response to oxygen deficiency under both physiological and pathological conditions such as cancer.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
19061057-3	2009	PC12 cells pre-conditioned with 35% O2 could generate a small quantity of reactive oxygen species (ROS), which activated the extracellular signal-regulated kinase (ERK) signalling pathway, then the over-expression of the B-cell lymphoma/leukaemia-2 (Bcl-2) was induced, which subsequently protected PC12 cell against death resulting from hypoxia exposure.	Oxygen	36-38	Eph receptor B1	Rattus norvegicus	125-162
19671047-1	2009	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein composed of HIF-1alpha and HIF-1alpha subunits, which is activated in response to reduced O2 availability.	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19671047-1	2009	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein composed of HIF-1alpha and HIF-1alpha subunits, which is activated in response to reduced O2 availability.	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19671047-1	2009	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein composed of HIF-1alpha and HIF-1alpha subunits, which is activated in response to reduced O2 availability.	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
19671047-1	2009	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein composed of HIF-1alpha and HIF-1alpha subunits, which is activated in response to reduced O2 availability.	Oxygen	152-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
19479577-5	2009	RESULTS: Peak oxygen uptake was 671 +/- 192 mL min(-1) (mean + standard deviation), peak HR 90 +/- 12 beats min(-1), net peak power 8.4 +/- 3.3 W and peak minute ventilation 23.6 +/- 7.5 L min(-1).	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	47-53
19061057-3	2009	PC12 cells pre-conditioned with 35% O2 could generate a small quantity of reactive oxygen species (ROS), which activated the extracellular signal-regulated kinase (ERK) signalling pathway, then the over-expression of the B-cell lymphoma/leukaemia-2 (Bcl-2) was induced, which subsequently protected PC12 cell against death resulting from hypoxia exposure.	Oxygen	36-38	Eph receptor B1	Rattus norvegicus	164-167
19061057-3	2009	PC12 cells pre-conditioned with 35% O2 could generate a small quantity of reactive oxygen species (ROS), which activated the extracellular signal-regulated kinase (ERK) signalling pathway, then the over-expression of the B-cell lymphoma/leukaemia-2 (Bcl-2) was induced, which subsequently protected PC12 cell against death resulting from hypoxia exposure.	Oxygen	36-38	BCL2, apoptosis regulator	Rattus norvegicus	221-248
19061057-3	2009	PC12 cells pre-conditioned with 35% O2 could generate a small quantity of reactive oxygen species (ROS), which activated the extracellular signal-regulated kinase (ERK) signalling pathway, then the over-expression of the B-cell lymphoma/leukaemia-2 (Bcl-2) was induced, which subsequently protected PC12 cell against death resulting from hypoxia exposure.	Oxygen	36-38	BCL2, apoptosis regulator	Rattus norvegicus	250-255
19321927-8	2009	ASCT2 mRNA levels were preserved at normoxia and downregulated at 1% O(2) after 48 h. CONCLUSION: Our data support the premise that the expression of GCMa and syncytin-1 precedes syncytialization of trophoblasts, e.g. at 6% O(2), which is assumed to resemble physiological conditions.	Oxygen	224-228	endogenous retrovirus group W member 1, envelope	Homo sapiens	159-169
20008248-4	2009	Congenital causes include mutations of the erythropoietin receptor and defects of the oxygen-sensing pathway including VHL, PHD2 and HIF2A mutations.	Oxygen	86-92	egl-9 family hypoxia inducible factor 1	Homo sapiens	124-128
19321927-6	2009	RESULTS: Following incubation with cAMP at 21% O(2), peak gene expression of syncytin-1 and GCMa was found after 24 h along with syncytium formation at 72 h. Conversely, incubation at 1% O(2) led to a time-dependent reduction of GCMa and syncytin-1 at the transcriptional level.	Oxygen	47-51	endogenous retrovirus group W member 1, envelope	Homo sapiens	77-87
19321927-6	2009	RESULTS: Following incubation with cAMP at 21% O(2), peak gene expression of syncytin-1 and GCMa was found after 24 h along with syncytium formation at 72 h. Conversely, incubation at 1% O(2) led to a time-dependent reduction of GCMa and syncytin-1 at the transcriptional level.	Oxygen	187-191	endogenous retrovirus group W member 1, envelope	Homo sapiens	77-87
19301653-2	2009	These are thought to be instigated by vascular endothelial growth factor, which in turn is regulated by cellular oxygen tension.	Oxygen	113-119	vascular endothelial growth factor A	Homo sapiens	38-72
19639506-0	2009	Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.	Oxygen	27-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	41-45
19639506-0	2009	Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.	Oxygen	27-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	47-53
19639506-1	2009	PURPOSE: Prolyl hydroxylase domain proteins constitute a family of oxygen sensors that regulate the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha), which mediates transcription of many genes under low oxygen concentration.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-146
19639506-1	2009	PURPOSE: Prolyl hydroxylase domain proteins constitute a family of oxygen sensors that regulate the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha), which mediates transcription of many genes under low oxygen concentration.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
19639506-1	2009	PURPOSE: Prolyl hydroxylase domain proteins constitute a family of oxygen sensors that regulate the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha), which mediates transcription of many genes under low oxygen concentration.	Oxygen	214-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-146
19639506-1	2009	PURPOSE: Prolyl hydroxylase domain proteins constitute a family of oxygen sensors that regulate the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha), which mediates transcription of many genes under low oxygen concentration.	Oxygen	214-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
18781596-6	2009	We clearly demonstrate that density-dependant HIF-1alpha accumulation during normoxia is due to the cells high consumption of oxygen, as demonstrated by using a respiration inhibitor (oligomycin) and respiratory-defective mutant cells (GSK3).	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
18781596-7	2009	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70(S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Oxygen	195-201	AKT serine/threonine kinase 1	Homo sapiens	67-70
18781596-7	2009	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70(S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Oxygen	195-201	mechanistic target of rapamycin kinase	Homo sapiens	162-166
18818681-0	2009	Regulation of oxygen utilization by angiotensin II in chronic kidney disease.	Oxygen	14-20	angiotensinogen	Rattus norvegicus	36-50
18924134-9	2009	Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-18
19607981-10	2009	Thus, our findings demonstrate that MS is neuroprotective in both in vivo and in vitro ischemic conditions, through a mechanism which may involve increased endogenous levels of H2O2 and its consequent conversion to molecular oxygen by catalase.	Oxygen	225-231	catalase	Rattus norvegicus	235-243
18704111-5	2009	In contrast, DC activation was obtained when PPD was chemically pre-oxidized or after air oxygen exposure.	Oxygen	90-96	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	45-48
19072214-1	2009	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19072214-1	2009	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
20384178-9	2009	Neither in men nor in women were plasma glucose and insulin levels correlated with maximal oxygen uptake.	Oxygen	91-97	insulin	Homo sapiens	52-59
19147540-0	2009	Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability.	Oxygen	97-103	mechanistic target of rapamycin kinase	Homo sapiens	50-79
19147540-7	2009	The regulatory features and the involvement of molecular oxygen itself in this regulation of HIF by mTOR are poorly understood.	Oxygen	57-63	mechanistic target of rapamycin kinase	Homo sapiens	100-104
19839829-9	2009	The beneficial effect of oxygen pretreatment in this group was associated with increased renal catalase activity compared with those obtained from control group (p &lt; 0.05).	Oxygen	25-31	catalase	Rattus norvegicus	95-103
19390974-12	2009	We concluded that 5 years of GH replacement promoted positive effects on exercise capacity and maximum oxygen uptake in spite of a modest increase in BP levels and left ventricular mass.	Oxygen	103-109	growth hormone 1	Homo sapiens	29-31
19149741-1	2009	In response to hypoxia, adaptive hypoxia-inducible factor-1 (HIF-1) signaling events are activated to increase oxygen transport, anaerobic energy production and protective pathways to minimize ischemic tissue damage.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-59
19149741-1	2009	In response to hypoxia, adaptive hypoxia-inducible factor-1 (HIF-1) signaling events are activated to increase oxygen transport, anaerobic energy production and protective pathways to minimize ischemic tissue damage.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
22573989-2	2009	CAT is present in almost all aerobic living organisms, where it catalyzes the disproportionation of H(2)O(2) into oxygen and water without forming free radicals.	Oxygen	114-120	catalase	Homo sapiens	0-3
19145387-8	2009	CRP value in this population had a statistically significant relation with admission to Intensive Care Unit (ICU) (p=0.008), length of hospital stay (p=0.025) and need for supplementary oxygen during hospital stay (p=0.022).	Oxygen	186-192	C-reactive protein	Homo sapiens	0-3
19950861-2	2009	It was shown that neopterin and 7, 8-dihydroneopterin while being a redox-pair regulated the process of oxygen activation in neutrophils by functioning of myeloperoxidase.	Oxygen	104-110	myeloperoxidase	Homo sapiens	155-170
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-92
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-92
18822394-3	2008	In this study, we investigated the role of TRP channels and the Na+-Ca2+ exchanger (NCX) in mediating hypoxia-induced [Ca2+]i elevation in a model of the O2-sensing rat pheochromocytoma (PC12) cell line by using Ca2+ imaging and molecular biological approaches.	Oxygen	154-156	solute carrier family 8 member A1	Rattus norvegicus	84-87
18940239-6	2008	Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.	Oxygen	10-16	cytoglobin	Homo sapiens	110-120
18816030-0	2008	Electronic state of the molecular oxygen released by catalase.	Oxygen	34-40	catalase	Homo sapiens	53-61
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Oxygen	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Oxygen	224-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18983820-0	2008	Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells.	Oxygen	46-52	transforming growth factor beta 1	Homo sapiens	84-116
18983820-0	2008	Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells.	Oxygen	46-52	transforming growth factor beta 1	Homo sapiens	118-127
19109240-0	2008	mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
19109240-1	2008	The activity of the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is increased in response to reduced intracellular oxygen.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-72
19109240-1	2008	The activity of the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is increased in response to reduced intracellular oxygen.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
18773881-11	2008	In our research NF-kappaB was found activated in INPCs after oxygen-glucose deprivation.	Oxygen	61-67	nuclear factor kappa B subunit 1	Homo sapiens	16-25
18922957-0	2008	Differential regulation of AMP-activated kinase and AKT kinase in response to oxygen availability in crucian carp (Carassius carassius).	Oxygen	78-84	AKT serine/threonine kinase 1	Homo sapiens	52-55
19061837-2	2008	Akt activation induces premature senescence and sensitizes cells to ROS-mediated apoptosis by increasing intracellular ROS through increased oxygen consumption and by inhibiting the expression of ROS scavengers downstream of FoxO, particularly sestrin 3.	Oxygen	141-147	AKT serine/threonine kinase 1	Homo sapiens	0-3
18834862-3	2008	Tumor survival requires oxygen supply through induced neovascularization, a process largely mediated by the vascular endothelial growth factor (VEGF), a prominent target of the transcription factors hypoxia-inducible factor-1 (HIF-1) and HIF-2.	Oxygen	24-30	vascular endothelial growth factor A	Homo sapiens	108-142
18834862-3	2008	Tumor survival requires oxygen supply through induced neovascularization, a process largely mediated by the vascular endothelial growth factor (VEGF), a prominent target of the transcription factors hypoxia-inducible factor-1 (HIF-1) and HIF-2.	Oxygen	24-30	vascular endothelial growth factor A	Homo sapiens	144-148
18834862-3	2008	Tumor survival requires oxygen supply through induced neovascularization, a process largely mediated by the vascular endothelial growth factor (VEGF), a prominent target of the transcription factors hypoxia-inducible factor-1 (HIF-1) and HIF-2.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	199-225
18922957-3	2008	In contrast, anoxia exposure (0.01 mg O2/l at 8 degrees C) substantially increased AMPK phosphorylation but decreased AKT phosphorylation in carp heart and brain, indicating activation of AMPK and deactivation of AKT.	Oxygen	38-40	AKT serine/threonine kinase 1	Homo sapiens	118-121
18922957-3	2008	In contrast, anoxia exposure (0.01 mg O2/l at 8 degrees C) substantially increased AMPK phosphorylation but decreased AKT phosphorylation in carp heart and brain, indicating activation of AMPK and deactivation of AKT.	Oxygen	38-40	AKT serine/threonine kinase 1	Homo sapiens	213-216
18922957-2	2008	We report that phosphorylation of AMPK and AKT in heart and brain showed small changes after 10 days of severe hypoxia (0.3 mg O2/l at 9 degrees C).	Oxygen	127-129	AKT serine/threonine kinase 1	Homo sapiens	43-46
19076451-9	2008	Erv1 directly interacts with Mia40 and shuttles electrons from reduced Mia40 to oxidized cytochrome c, from whence they flow through cytochrome oxidase to molecular oxygen.	Oxygen	165-171	cytochrome c, somatic	Homo sapiens	89-101
18795957-2	2008	The transcriptional profiles reported in previous studies of cells grown under anaerobic, aerobic and dynamic growth conditions have shown significantly altered responses including induction of genes regulated by the oxidative stress transcription factor Yap1p when oxygen was present.	Oxygen	266-272	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	255-260
19107989-9	2008	B6.MRL-Tnfrsf6(lpr) mice were protected against oxygen-mediated injury, confirming Fas involvement in hyperoxia-induced cell death.	Oxygen	48-54	Fas (TNF receptor superfamily member 6)	Mus musculus	7-14
19001187-0	2008	Angiotensin II-dependent hypertension increases Na transport-related oxygen consumption by the thick ascending limb.	Oxygen	69-75	angiotensinogen	Rattus norvegicus	0-14
18236154-1	2008	Erythropoietin, the primary regulator of erythropoiesis, is produced by the kidney and levels vary inversely with oxygen availability.	Oxygen	114-120	erythropoietin	Homo sapiens	0-14
18236154-2	2008	Hypoxia-inducible factor-1 (HIF-1), a major transcriptional regulator of several hypoxia-sensitive genes, including erythropoietin, is functionally deactivated by oxygen in a reaction catalyzed by prolyl hydroxylase.	Oxygen	163-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
18236154-2	2008	Hypoxia-inducible factor-1 (HIF-1), a major transcriptional regulator of several hypoxia-sensitive genes, including erythropoietin, is functionally deactivated by oxygen in a reaction catalyzed by prolyl hydroxylase.	Oxygen	163-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
18236154-2	2008	Hypoxia-inducible factor-1 (HIF-1), a major transcriptional regulator of several hypoxia-sensitive genes, including erythropoietin, is functionally deactivated by oxygen in a reaction catalyzed by prolyl hydroxylase.	Oxygen	163-169	erythropoietin	Homo sapiens	116-130
18942689-7	2008	Anti-TNF antibody (Ab) pretreatment did not inhibit the increase of Kupffer cells, but it effectively suppressed superoxide/reactive oxygen production from Kupffer cells and the resulting hepatic injury.	Oxygen	133-139	tumor necrosis factor	Mus musculus	5-8
19001187-5	2008	Ang II-dependent hypertension increased furosemide-sensitive oxygen consumption (26.2+/-1.0% versus 36.6+/-1.2% of total oxygen consumption; P&lt;0.01).	Oxygen	61-67	angiotensinogen	Rattus norvegicus	0-6
19001187-5	2008	Ang II-dependent hypertension increased furosemide-sensitive oxygen consumption (26.2+/-1.0% versus 36.6+/-1.2% of total oxygen consumption; P&lt;0.01).	Oxygen	121-127	angiotensinogen	Rattus norvegicus	0-6
19037001-15	2008	IL-1beta decreased oxygen consumption of the R28 cells by nearly half, but did not lower cytochrome c oxidase activity.	Oxygen	19-25	interleukin 1 beta	Rattus norvegicus	0-8
18838541-0	2008	Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-111
18808197-3	2008	The complexes of Fe(II) and Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Oxygen	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
18808197-10	2008	It was determined that oxidation of DNA by molecular oxygen catalyzed by complex of Fe(II)-phthalocyanines proceeds with higher rate than in the case of Co(II)-phthalocyanines but the latter led to a greater extent of target DNA modification.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
18208562-0	2008	Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
19027603-0	2008	Associations of monocytes, neutrophil count, and C-reactive protein with maximal oxygen uptake in overweight women.	Oxygen	81-87	C-reactive protein	Homo sapiens	49-67
18838541-2	2008	A key regulator of HIF-1alpha is von Hippel-Lindau protein (pVHL), which mediates the oxygen-dependent, proteasomal degradation of HIF-1alpha in normoxia.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
18838541-2	2008	A key regulator of HIF-1alpha is von Hippel-Lindau protein (pVHL), which mediates the oxygen-dependent, proteasomal degradation of HIF-1alpha in normoxia.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
18838541-3	2008	Here, we describe a new regulator of HIF-1alpha, the hypoxia-associated factor (HAF), a novel E3-ubiquitin ligase that binds HIF-1alpha leading to its proteasome-dependent degradation irrespective of cellular oxygen tension.	Oxygen	209-215	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
18838541-3	2008	Here, we describe a new regulator of HIF-1alpha, the hypoxia-associated factor (HAF), a novel E3-ubiquitin ligase that binds HIF-1alpha leading to its proteasome-dependent degradation irrespective of cellular oxygen tension.	Oxygen	209-215	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-135
18838541-8	2008	Therefore, HAF is the key mediator of a new HIF-1alpha-specific degradation pathway that degrades HIF-1alpha through a new, oxygen-independent mechanism.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
18838541-8	2008	Therefore, HAF is the key mediator of a new HIF-1alpha-specific degradation pathway that degrades HIF-1alpha through a new, oxygen-independent mechanism.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
19048259-8	2008	Oxygen-dependent vascular endothelial growth factor (VEGF) and oxygen-independent insulin-like growth factor (IGF-1) have been identified as important factors in the pathogenesis of ROP.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	17-51
19048259-8	2008	Oxygen-dependent vascular endothelial growth factor (VEGF) and oxygen-independent insulin-like growth factor (IGF-1) have been identified as important factors in the pathogenesis of ROP.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	53-57
19198181-4	2008	We have found that SOD3 minimizes O2- levels preserving NO availability at resting conditions.	Oxygen	34-36	superoxide dismutase 3	Homo sapiens	19-23
19198181-5	2008	SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO.	Oxygen	55-57	superoxide dismutase 3	Homo sapiens	0-4
19198181-5	2008	SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO.	Oxygen	103-105	superoxide dismutase 3	Homo sapiens	0-4
19198181-5	2008	SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO.	Oxygen	103-105	superoxide dismutase 3	Homo sapiens	69-73
19198181-5	2008	SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO.	Oxygen	124-130	superoxide dismutase 3	Homo sapiens	0-4
19198181-5	2008	SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO.	Oxygen	124-130	superoxide dismutase 3	Homo sapiens	69-73
18765227-1	2008	The Cu-Zn superoxide dismutase (SOD1) belongs to a family of isoenzymes that are able to dismutate the oxygen superoxide in hydrogen peroxide and molecular oxygen.	Oxygen	103-109	superoxide dismutase 1	Rattus norvegicus	32-36
18776187-6	2008	Maximal PHD2 activity was found between 120 and 210 microm O2.	Oxygen	59-61	egl-9 family hypoxia inducible factor 1	Homo sapiens	8-12
18776187-7	2008	PHD2 activity was strongly decreased below 100 microm O2 with a half-maximum activity at 53 +/- 13 microm O2 for the cytosolic and 54 +/- 10 microm O2 for nuclear PHD2 matching the physiological O2 concentration within most cells.	Oxygen	54-56	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
18776187-7	2008	PHD2 activity was strongly decreased below 100 microm O2 with a half-maximum activity at 53 +/- 13 microm O2 for the cytosolic and 54 +/- 10 microm O2 for nuclear PHD2 matching the physiological O2 concentration within most cells.	Oxygen	54-56	egl-9 family hypoxia inducible factor 1	Homo sapiens	163-167
18776187-7	2008	PHD2 activity was strongly decreased below 100 microm O2 with a half-maximum activity at 53 +/- 13 microm O2 for the cytosolic and 54 +/- 10 microm O2 for nuclear PHD2 matching the physiological O2 concentration within most cells.	Oxygen	106-108	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
18776187-7	2008	PHD2 activity was strongly decreased below 100 microm O2 with a half-maximum activity at 53 +/- 13 microm O2 for the cytosolic and 54 +/- 10 microm O2 for nuclear PHD2 matching the physiological O2 concentration within most cells.	Oxygen	106-108	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
18776187-7	2008	PHD2 activity was strongly decreased below 100 microm O2 with a half-maximum activity at 53 +/- 13 microm O2 for the cytosolic and 54 +/- 10 microm O2 for nuclear PHD2 matching the physiological O2 concentration within most cells.	Oxygen	106-108	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-4
18776187-8	2008	Our data suggest a role for PHD2 as a decisive oxygen sensor of the hypoxia-inducible factor degradation pathway within the cell nucleus.	Oxygen	47-53	egl-9 family hypoxia inducible factor 1	Homo sapiens	28-32
18840459-4	2008	The gsh1 strain showed an increase in cell yield under calorie restriction that was associated with a higher pyruvate kinase activity and a reduction in oxygen consumption and aconitase activity.	Oxygen	153-159	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	4-8
18779333-5	2008	Interference with Tfam resulted in cells with decreased respiratory chain capacity, reflected by decreased basal oxygen consumption, and decreased mitochondrial ATP synthesis, but no difference in many other adipocyte functions or expression levels of adipose-specific genes.	Oxygen	113-119	transcription factor A, mitochondrial	Homo sapiens	18-22
18765230-6	2008	Under serum-deprived hypoxic (1% oxygen) conditions, TNF-alpha expression in HUVECs increased relative to normoxic (20% oxygen) and serum-containing conditions.	Oxygen	33-39	tumor necrosis factor	Homo sapiens	53-62
18765230-6	2008	Under serum-deprived hypoxic (1% oxygen) conditions, TNF-alpha expression in HUVECs increased relative to normoxic (20% oxygen) and serum-containing conditions.	Oxygen	120-126	tumor necrosis factor	Homo sapiens	53-62
18839991-7	2008	These PCB (hydro-)quinones readily react with oxygen or via comproportionation to yield the corresponding semiquinone free radicals, as detected by electron paramagnetic resonance spectroscopy (EPR alias ESR).	Oxygen	46-52	pyruvate carboxylase	Homo sapiens	6-9
18854902-6	2008	The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex.	Oxygen	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
19054859-1	2008	Home care cries foul over CMS oxygen therapy reg.	Oxygen	30-36	regenerating family member 1 alpha	Homo sapiens	45-48
18980686-0	2008	Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene are not associated with pre-eclampsia in the Finnish population.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
18474670-0	2008	Role of oxygen availability in CFTR expression and function.	Oxygen	8-14	CF transmembrane conductance regulator	Homo sapiens	31-35
18694997-4	2008	Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molecules) in response to lipopolysaccharide (LPS), as well as their stimulatory capacity for T-cell functions.	Oxygen	4-10	CD1d1 antigen	Mus musculus	100-104
18787063-7	2008	Administration of rebamipide, a gastroprotective drug that acts as an oxygen-derived free radical scavenger, significantly decreased LPO and nitrotyrosine as well as the nitration of ERK by peroxynitrite in PHT gastric mucosa, therefore normalizing ERK activation and restoring the gastric mucosal healing response to ethanol injury.	Oxygen	70-76	Eph receptor B1	Rattus norvegicus	183-186
18826240-1	2008	Cu, Zn-superoxide dismutase (SOD-1), an enzyme that catalyzes the disproportionation reaction of superoxide to produce oxygen and hydrogen peroxide, thereby protecting cells from oxidative stress, is a homodimer that coordinates one copper and one zinc ion per monomer.	Oxygen	119-125	superoxide dismutase 1	Homo sapiens	29-34
18694997-4	2008	Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molecules) in response to lipopolysaccharide (LPS), as well as their stimulatory capacity for T-cell functions.	Oxygen	4-10	CD80 antigen	Mus musculus	112-116
18694997-4	2008	Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molecules) in response to lipopolysaccharide (LPS), as well as their stimulatory capacity for T-cell functions.	Oxygen	4-10	CD83 antigen	Mus musculus	118-122
18694997-4	2008	Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molecules) in response to lipopolysaccharide (LPS), as well as their stimulatory capacity for T-cell functions.	Oxygen	4-10	CD86 antigen	Mus musculus	124-128
18703498-7	2008	Therefore, SOD1 localization responds to changes in environmental conditions following redistribution of CCS, which operates as an oxygen sensor.	Oxygen	131-137	superoxide dismutase 1	Homo sapiens	11-15
18721997-6	2008	In contrast to the suggestion that inter system crossing can be highly efficient with reaction originating from a PCB triplet, oxygen quenching data suggest that a significant minimum of the quantum yield is non-quenchable, presumably because of a reaction path from the PCB singlet.	Oxygen	127-133	pyruvate carboxylase	Homo sapiens	114-117
18721997-6	2008	In contrast to the suggestion that inter system crossing can be highly efficient with reaction originating from a PCB triplet, oxygen quenching data suggest that a significant minimum of the quantum yield is non-quenchable, presumably because of a reaction path from the PCB singlet.	Oxygen	127-133	pyruvate carboxylase	Homo sapiens	271-274
19090810-8	2008	The addition of superoxide dismutase prolonged the half-life of the signal, which suggested that increased oxygen radical formation occurred in the STZ Nrf2 KO mice.	Oxygen	107-113	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
18924608-6	2008	Hyperactivated PI3K/Akt signaling led to upregulation of Notch1 through NF-kappaB activity, while the low oxygen content normally found in skin increased mRNA and protein levels of Notch1 via stabilization of HIF-1alpha.	Oxygen	106-112	notch receptor 1	Homo sapiens	181-187
18682967-1	2008	Circulating erythropoietin (EPO) is mainly produced in the kidneys, depending on blood oxygen level.	Oxygen	87-93	erythropoietin	Homo sapiens	12-26
18682967-1	2008	Circulating erythropoietin (EPO) is mainly produced in the kidneys, depending on blood oxygen level.	Oxygen	87-93	erythropoietin	Homo sapiens	28-31
18617020-9	2008	TNF-alpha, which is an important cytokine for oxygen independent killing by macrophage also increased by methylglyoxal in both tumor-bearing and non tumor-bearing animals.	Oxygen	46-52	tumor necrosis factor	Mus musculus	0-9
18924608-6	2008	Hyperactivated PI3K/Akt signaling led to upregulation of Notch1 through NF-kappaB activity, while the low oxygen content normally found in skin increased mRNA and protein levels of Notch1 via stabilization of HIF-1alpha.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-219
19017170-2	2008	EPO also mediates other effects directed towards optimizing oxygen delivery to tissues, e.g. modulating regional blood flow and reducing blood loss by promoting thrombosis within damaged vessels.	Oxygen	60-66	erythropoietin	Homo sapiens	0-3
18316093-10	2008	CONCLUSIONS: Hyperbaric oxygen inhibits IR-induced neutrophil adhesion by blocking CD18 surface polarization and requires plasma exposure to HBO.	Oxygen	24-30	integrin subunit beta 2	Rattus norvegicus	83-87
18947306-13	2008	Conversely, we identified 302 gene upregulations and 56 downregulations when comparing 21% O(2) (p0p10) with 2% O2 (p10).	Oxygen	91-95	S100 calcium binding protein A10	Homo sapiens	99-102
18673420-3	2008	NO donors may be useful to induce the transcription factor hypoxia inducible factor 1 (HIF-1), which coordinates the protection of cells and tissues from the lack of oxygen (hypoxia).	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-85
18673420-3	2008	NO donors may be useful to induce the transcription factor hypoxia inducible factor 1 (HIF-1), which coordinates the protection of cells and tissues from the lack of oxygen (hypoxia).	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
18650791-4	2008	This receptor blocker decreased reactive oxygen generation elicited by either TNF or the pro-oxidant hydrogen peroxide and reinstated redox homeostasis, suggesting a direct antioxidant effect.	Oxygen	41-47	tumor necrosis factor	Rattus norvegicus	78-81
21479491-3	2008	ASC was inducible under a 1% O2 hypoxic condition in pancreatic cancer cells, which was HIF1alpha-dependent but p53-independent.	Oxygen	29-31	PYD and CARD domain containing	Homo sapiens	0-3
21479491-3	2008	ASC was inducible under a 1% O2 hypoxic condition in pancreatic cancer cells, which was HIF1alpha-dependent but p53-independent.	Oxygen	29-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-97
21479491-3	2008	ASC was inducible under a 1% O2 hypoxic condition in pancreatic cancer cells, which was HIF1alpha-dependent but p53-independent.	Oxygen	29-31	tumor protein p53	Homo sapiens	112-115
18959466-3	2008	Glucose oxidase is employed to deplete oxygen from the medium by selectively oxidizing glucose and reducing molecular oxygen to hydrogen peroxide; an excess of catalase is also used to scavenge the peroxide molecules.	Oxygen	39-45	catalase	Homo sapiens	160-168
18809331-2	2008	It is widely accepted that HIF-1alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
18768468-3	2008	Kinetic analysis indicates the compounds can irreversibly inactivate caspase-3 in a 1,4-dithiothreitol (DTT)- and oxygen-dependent manner, implying that a redox cycle might take place in the inactivation process.	Oxygen	114-120	caspase 3	Homo sapiens	69-78
18927305-0	2008	Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.	Oxygen	22-28	egl-9 family hypoxia inducible factor 1	Homo sapiens	44-49
18927305-2	2008	Our aim was to assess the expression of proteins that act as cellular oxygen sensors, directly regulating the hypoxia inducible factor (HIF) pathway, i.e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET).	Oxygen	70-76	egl-9 family hypoxia inducible factor 1	Homo sapiens	200-205
18694926-1	2008	The hypoxia-inducible factor-1alpha (HIF-1alpha) is a master regulator of the cellular response to decreased oxygen levels.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
18694926-1	2008	The hypoxia-inducible factor-1alpha (HIF-1alpha) is a master regulator of the cellular response to decreased oxygen levels.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
18789444-6	2008	The combined macro-scale/micro-scale approach indicated that 0.3 ml min(-1), which subjected 95% of the cells to less than 6.3 mPa shear, would maintain the oxygen supply throughout the scaffold above anoxic levels (&gt;1%), with 99.5% of the scaffold supplied with 8-2% O(2).	Oxygen	157-163	CD59 molecule (CD59 blood group)	Homo sapiens	68-74
18768468-5	2008	Oxygen-free radical scavenger catalase and superoxide dismutase eliciting the inactivation of caspase-3 by the inhibitors confirm that ROS mediates the inactivation process.	Oxygen	0-6	caspase 3	Homo sapiens	94-103
18827009-2	2008	These changes are dependent on the generation of nitric oxide (NO) by an inducible NO synthase that becomes a significant consumer of oxygen.	Oxygen	134-140	nitric oxide synthase 2, inducible	Mus musculus	73-94
18774795-0	2008	Influence of ligand polarizability on the reversible binding of O2 by trans-[Rh(X)(XNC)(PPh3)2] (X = Cl, Br, SC6F5, C2Ph; XNC = xylyl isocyanide).	Oxygen	64-66	caveolin 1	Homo sapiens	88-92
18687685-2	2008	Its regulated subunit, HIF-1alpha, is controlled by oxygen levels and major signaling pathways.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
26047280-2	2008	Dissolved oxygen (DO) level became a limiting factor for HA production during 8-16h, and thus hyaluronidase (0.05, 0.10, 0.15, 0.20, 0.25g/l) was added at 8h to degrade HA.	Oxygen	10-16	beta-N-acetylglucosaminidase domain-containing protein	Streptococcus equi subsp. zooepidemicus	94-107
26047280-3	2008	Oxygen transfer rate coefficient and DO level during 8-16h increased with increased hyaluronidase concentration.	Oxygen	0-6	beta-N-acetylglucosaminidase domain-containing protein	Streptococcus equi subsp. zooepidemicus	84-97
21832625-5	2008	The growth of the CdO pyramidal nanostructures takes place in the solid-liquid-solid phase, with the rates determined by the interaction of plasma-produced oxygen atoms and ions with the surface.	Oxygen	156-162	cell adhesion associated, oncogene regulated	Homo sapiens	18-21
18839041-1	2008	BACKGROUND: Hypoxia-inducible factor 1 (HIF)-1alpha is a transcription factor that functions as master regulator of mammalian oxygen homeostasis.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-51
18555029-6	2008	Because of its low P50 and increased molecular size, the release of O2 in resistance vessels (arterioles) by Hemospan is restricted, and vasoconstriction is greatly reduced.	Oxygen	68-70	nuclear factor kappa B subunit 1	Homo sapiens	19-22
18658046-1	2008	OBJECTIVE: Hypoxia-inducible factor 1alpha (HIF-1alpha) is primarily involved in the adapting of cells to changes in oxygen levels, which is essential for normal vascular function.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-42
18658046-1	2008	OBJECTIVE: Hypoxia-inducible factor 1alpha (HIF-1alpha) is primarily involved in the adapting of cells to changes in oxygen levels, which is essential for normal vascular function.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
18926407-10	2008	Pre-transplant priming of donor lungs with thioredoxin-1 improved oxygen exchange and attenuated NF-kappaB/DNA binding activity, and infiltration of macrophages, neutrophils, and CD8(+) T cell sub-sets in allografts at Days 1 and 5 post-transplant.	Oxygen	66-72	thioredoxin 1	Rattus norvegicus	43-56
18551145-4	2008	Stable MDA-MB-435 cells expressing the chimeric therapeutic gene under 1% O2 showed an increase in stable HIF-1alpha protein levels and synthesis of the endonuclease G protein in a time-dependent manner.	Oxygen	74-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
18795948-0	2008	Oxygen-induced changes in hemoglobin expression in Drosophila.	Oxygen	0-6	globin 1	Drosophila melanogaster	26-36
18795948-4	2008	We show that expression levels of dmeglob1 are decreased under both short- and long-term hypoxia, compared with the normoxic (21% O2) control.	Oxygen	130-132	globin 1	Drosophila melanogaster	34-42
18795948-6	2008	An excess of O2 (hyperoxia) also triggered an increase in dmeglob1 mRNA.	Oxygen	13-15	globin 1	Drosophila melanogaster	58-66
18795948-8	2008	Rather, dmeglob1 may protect the fly from an excess of O2, either by buffering the flux of O2 from the tracheoles to the cells or by degrading noxious reactive oxygen species.	Oxygen	55-57	globin 1	Drosophila melanogaster	8-16
18795948-8	2008	Rather, dmeglob1 may protect the fly from an excess of O2, either by buffering the flux of O2 from the tracheoles to the cells or by degrading noxious reactive oxygen species.	Oxygen	91-93	globin 1	Drosophila melanogaster	8-16
18689483-1	2008	Part of the oxygen responsiveness of Rhodobacter sphaeroides 2.4.1 tetrapyrrole production involves changes in transcription of the hemA gene, which codes for one of two isoenzymes catalyzing 5-aminolevulinic acid synthesis.	Oxygen	12-18	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	132-136
18692496-5	2008	Although Sirt1 was up-regulated in both cell lines by 3% oxygen the effects on antioxidant enzymes (MnSOD, CuZnSOD and catalase) were cell line specific.	Oxygen	57-63	sirtuin 1	Rattus norvegicus	9-14
18710233-6	2008	Our results establish the oxygen of the ubiquitous siderophore hydroxamate functionality as a nucleophile and may be indicative of general strategy for N-O-C bond formation in nature.	Oxygen	26-32	nocturnin	Homo sapiens	152-157
18955813-1	2008	Superoxide dismutase (SOD) removes damaging reactive oxygen species from the cellular environment by catalyzing the dismutation of two superoxide radicals to hydrogen peroxide and oxygen.	Oxygen	53-59	superoxide dismutase 3	Homo sapiens	22-25
17622488-11	2008	The relationship between the level of hypoxemia and microalbuminuria, fibrinogen and vWF was found to be significant (r = -0.360, P = 0.005 between oxygen saturation and microalbuminuria, r = -0.359, P = 0.005 between the level of PaO(2) and fibrinogen, and r = -0.336, P = 0.009 between PaO(2) and vWF).	Oxygen	148-154	fibrinogen beta chain	Homo sapiens	70-80
17622488-11	2008	The relationship between the level of hypoxemia and microalbuminuria, fibrinogen and vWF was found to be significant (r = -0.360, P = 0.005 between oxygen saturation and microalbuminuria, r = -0.359, P = 0.005 between the level of PaO(2) and fibrinogen, and r = -0.336, P = 0.009 between PaO(2) and vWF).	Oxygen	148-154	von Willebrand factor	Homo sapiens	85-88
18926064-10	2008	CONCLUSION: Exposure of AEC II from immature rat to 60% oxygen for 24 hours may produce oxidative injury, inducing apoptosis and decrease in SPC mRNA level of AEC II of premature rat in vitro, while CGRP may play a protective role against hyperoxic lung injury by its antioxidant property, and also inhibition of AEC II apoptosis and promotion of the SPC mRNA expression.	Oxygen	56-62	surfactant protein C	Rattus norvegicus	141-144
18926064-10	2008	CONCLUSION: Exposure of AEC II from immature rat to 60% oxygen for 24 hours may produce oxidative injury, inducing apoptosis and decrease in SPC mRNA level of AEC II of premature rat in vitro, while CGRP may play a protective role against hyperoxic lung injury by its antioxidant property, and also inhibition of AEC II apoptosis and promotion of the SPC mRNA expression.	Oxygen	56-62	surfactant protein C	Rattus norvegicus	351-354
18713836-3	2008	Signals generated by scratch wounding stabilise the HIF1alpha protein, which requires activation of the PI3K pathway independently of oxygen availability.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-61
18948754-4	2008	In this study, we retrovirally transduced TIG-7 human fibroblasts with a shRNA against PASG and compared the rate of change in DNA methylation as well as the replicative life-span to control cells under low (3%) and ambient (20%) oxygen.	Oxygen	230-236	helicase, lymphoid specific	Homo sapiens	87-91
18826332-1	2008	Beta-defensin antimicrobial peptides are multifunctional biomolecules, which are a major component of the oxygen-independent microbicidal system of buffalo polymorphonuclear (PMN) cells.	Oxygen	106-112	LOC100296173	Bos taurus	0-13
18595776-0	2008	Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice.	Oxygen	11-17	apolipoprotein E	Mus musculus	84-100
18639543-1	2008	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
18639543-1	2008	Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
18769544-6	2008	Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gammadelta and alphabeta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB) dysfunction and hypothermia.	Oxygen	12-18	tumor necrosis factor	Mus musculus	73-82
18769544-6	2008	Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gammadelta and alphabeta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB) dysfunction and hypothermia.	Oxygen	12-18	interferon gamma	Mus musculus	84-93
18769544-6	2008	Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gammadelta and alphabeta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB) dysfunction and hypothermia.	Oxygen	12-18	interleukin 10	Mus musculus	98-103
18448591-7	2008	In adults, certain hormones--estrogen and vasopressin (usually elevated in cases of hyponatremia)--have been shown to impair brain adaptation, decreasing both cerebral blood flow and oxygen utilization.	Oxygen	183-189	arginine vasopressin	Homo sapiens	42-53
18448591-11	2008	In menstruant women, estrogen + vasopressin inhibits the Na(+)-K(+)-ATPase system and decreases cerebral oxygen utilization, impairing brain adaptation.	Oxygen	105-111	arginine vasopressin	Homo sapiens	32-43
17473988-6	2008	Meanwhile, each phase of the cell cycle was detected to have increased expression of HIF-1alpha in response to oxygen-deficient treatment.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
18461556-6	2008	Taken together, these results indicate that PGF2alpha promotes the activation of the HIF-1 transcription factor pathway under normal oxygen conditions, and highlight a potential role for the normoxic activation of the HIF-1/DEC1-pathway in mediating the inhibitory effects of PGF2alpha on adipocyte differentiation.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-90
19759857-1	2008	Nitric oxide synthase (NOS) catalyzes the production of nitric oxide from L-arginine and dioxygen at a thiolate-ligated heme active site.	Oxygen	89-97	nitric oxide synthase 2	Homo sapiens	0-21
18617693-9	2008	The hypoxia-induced apelin expression may, thus, provide a new mechanism involved in adaptive physiological and pathophysiological response of vascular cells to low oxygen level.	Oxygen	165-171	apelin	Homo sapiens	20-26
18578010-3	2008	Hypoxia-responsive cis elements were used in tandem with a single proline-modified oxygen-dependent degradation (ODD) domain of hypoxia-inducible factor-1alpha to form a double oxygen-sensing vector system (DOSVS).	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-159
18578010-3	2008	Hypoxia-responsive cis elements were used in tandem with a single proline-modified oxygen-dependent degradation (ODD) domain of hypoxia-inducible factor-1alpha to form a double oxygen-sensing vector system (DOSVS).	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-159
18672900-3	2008	These regulators of CO metabolism, BxRcoM-1 and BxRcoM-2, are gas-responsive heme-PAS domain proteins like mammalian neuronal PAS domain protein 2 (NPAS2) and the direct oxygen sensor from Escherichia coli ( EcDos).	Oxygen	170-176	neuronal PAS domain protein 2	Homo sapiens	117-146
18672900-3	2008	These regulators of CO metabolism, BxRcoM-1 and BxRcoM-2, are gas-responsive heme-PAS domain proteins like mammalian neuronal PAS domain protein 2 (NPAS2) and the direct oxygen sensor from Escherichia coli ( EcDos).	Oxygen	170-176	neuronal PAS domain protein 2	Homo sapiens	148-153
18486631-1	2008	Decreased oxygen availability evokes adaptive responses, which are primarily under the gene regulatory control of hypoxia inducible factor-1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-140
18486631-1	2008	Decreased oxygen availability evokes adaptive responses, which are primarily under the gene regulatory control of hypoxia inducible factor-1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-147
18503779-3	2008	However, under hypoxic conditions, the ubiquitination system for HIF-1 alpha is inhibited by inactivation of prolyl hydroxylase which is responsible for hydroxylation of proline in the oxygen-dependent degradation domain of HIF-1 alpha.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-76
18503779-3	2008	However, under hypoxic conditions, the ubiquitination system for HIF-1 alpha is inhibited by inactivation of prolyl hydroxylase which is responsible for hydroxylation of proline in the oxygen-dependent degradation domain of HIF-1 alpha.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	224-235
18509654-6	2008	By estimating and measuring the extent of cell death, release of active oxygen species, and accumulation defense-associated gene transcripts, it is shown that bax transgenic plants mount a more robust cell death response compared to control plants.	Oxygen	72-78	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
18708911-5	2008	Exposure to 60 min of 2.1% isoflurane inhalation with oxygen 24 h before ischemia significantly reduced I/R-induced myocardial infarct size that was associated with overexpression of iNOS protein and increased NO content in the heart.	Oxygen	54-60	nitric oxide synthase 2	Rattus norvegicus	183-187
18714372-1	2008	Treatment with recombinant human erythropoietin (rhEpo) induces a rise in blood oxygen-carrying capacity (CaO(2)) that unequivocally enhances maximal oxygen uptake (VO(2)max) during exercise in normoxia, but not when exercise is carried out in severe acute hypoxia.	Oxygen	80-86	erythropoietin	Homo sapiens	33-47
18714372-1	2008	Treatment with recombinant human erythropoietin (rhEpo) induces a rise in blood oxygen-carrying capacity (CaO(2)) that unequivocally enhances maximal oxygen uptake (VO(2)max) during exercise in normoxia, but not when exercise is carried out in severe acute hypoxia.	Oxygen	150-156	erythropoietin	Homo sapiens	33-47
18565696-1	2008	The hypoxia-inducible factor-1 alpha (HIF-1alpha) protein is the major regulator of oxygen-dependent gene expression and a member of the bHLH-PAS family of transcription factors.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48
18565696-6	2008	We suggest that the relaxed selective constraints in teleost HIF-1alpha may be associated with the variable environmental oxygen levels to which teleosts have been exposed during their evolutionary history.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
18582035-1	2008	Co(III) corroles were investigated as efficient catalysts for the reduction of dioxygen in the presence of perchloric acid in both heterogeneous and homogeneous systems.	Oxygen	79-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	0-7
18648693-1	2008	In nature the four electron reduction of O2 to H2O is carried out by Cytochrome c oxidase (CcO) and the multicopper oxidases (MCOs).	Oxygen	41-43	cytochrome c, somatic	Homo sapiens	69-81
18438939-2	2008	HIF-1alpha promotes the expression of genes encoding proteins that increase the cellular supply of oxygen and promote survival in periods of cellular stress and availability of cellular energy.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
18518865-4	2008	The mean (SD) fractional end-tidal oxygen at the end of 3 min was 0.86 (0.07) for 5 l.min(-1), 0.92 (0.05) for 10 l.min(-1)and 0.90 (0.09) for 15 l.min(-1) (p &lt; 0.001).	Oxygen	35-41	CD59 molecule (CD59 blood group)	Homo sapiens	86-92
18518865-4	2008	The mean (SD) fractional end-tidal oxygen at the end of 3 min was 0.86 (0.07) for 5 l.min(-1), 0.92 (0.05) for 10 l.min(-1)and 0.90 (0.09) for 15 l.min(-1) (p &lt; 0.001).	Oxygen	35-41	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
18518865-4	2008	The mean (SD) fractional end-tidal oxygen at the end of 3 min was 0.86 (0.07) for 5 l.min(-1), 0.92 (0.05) for 10 l.min(-1)and 0.90 (0.09) for 15 l.min(-1) (p &lt; 0.001).	Oxygen	35-41	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
18518865-6	2008	Oxygen flow rates of 10 l.min(-1) or above provide optimal pre-oxygenation using a circle system in term parturients.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	26-32
18557976-12	2008	Our best hypothesis is that the presence of ROS-destroying enzymes such as peroxiredoxins and a lower dissolved O2 concentration in those msr-lacking organisms grown at high temperatures might account for the successful survival of these organisms under oxidative stress.	Oxygen	112-114	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	138-141
18063561-0	2008	Neurotensin receptor involvement in the rise of extracellular glutamate levels and apoptotic nerve cell death in primary cortical cultures after oxygen and glucose deprivation.	Oxygen	145-151	neurotensin	Homo sapiens	0-11
18474440-6	2008	Treatment with 1% O2 markedly increased the gene expression levels of iNOS and MMP-9, indicating that ras/myc SFME cells alter the expression levels of tumor-associated genes and possibly enhance their malignancy as cancer cells under inflammatory, infectious and hypoxic conditions.	Oxygen	18-20	nitric oxide synthase 2, inducible	Mus musculus	70-74
18535160-4	2008	Exposing hESC-derived EBs to ambient oxygen at or below 5% results in stabilization of HIF-1alpha and increased transcription of hypoxic responsive genes.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
18375543-4	2008	TG2 is up-regulated in neurons exposed to oxygen and glucose deprivation (OGD), and increased TG2 expression protects neurons against OGD-induced cell death independent of its transamidating activity.	Oxygen	42-48	transglutaminase 2	Homo sapiens	0-3
18676825-7	2008	Enhancing CtBP-mediated repression by growing cells in low oxygen increased the association of CtBP with the p16 promoter, as assessed by chromatin immunoprecipitation, and reduced p16 expression.	Oxygen	59-65	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
18676825-7	2008	Enhancing CtBP-mediated repression by growing cells in low oxygen increased the association of CtBP with the p16 promoter, as assessed by chromatin immunoprecipitation, and reduced p16 expression.	Oxygen	59-65	cyclin dependent kinase inhibitor 2A	Homo sapiens	181-184
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Oxygen	91-97	ATP binding cassette subfamily B member 1	Homo sapiens	166-180
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Oxygen	91-97	ATP binding cassette subfamily B member 1	Homo sapiens	182-185
18460651-6	2008	Pah-1 mutants show stimulation of superoxide dismutase activity, suggesting that cuticle melanin functions as oxygen radical scavenger.	Oxygen	110-116	Phenylalanine-4-hydroxylase	Caenorhabditis elegans	0-5
18583375-1	2008	BACKGROUND: the main action of recombinant human erythropoietin (rHuEpo) is to increase the oxygen carrying capacity of the blood.	Oxygen	92-98	erythropoietin	Homo sapiens	49-63
18535134-1	2008	This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood.	Oxygen	141-147	erythropoietin	Homo sapiens	89-103
18535134-1	2008	This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood.	Oxygen	186-192	erythropoietin	Homo sapiens	89-103
18414140-6	2008	Thus, in newborn cord blood, the higher number of red cells and reticulocytes with lower Hb content may have impaired the oxygen carrying capacity that has been a trigger for EPO production.	Oxygen	122-128	erythropoietin	Homo sapiens	175-178
26631704-1	2008	Density Functional Theory (DFT) has been applied to a comprehensive mechanistic study of the conversion reaction of the Pd(II)-hydride complex, (IMe)2(RCO2)PdH (R=CH3, Ph, and p-O2NC6H4), to the corresponding Pd(II)-hydroperoxide in the presence of molecular oxygen.	Oxygen	259-265	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	156-159
26631704-6	2008	In addition, according to the experimentally detected enhancement of the reaction rate due to the presence of a nitro group on the benzoate ligand, our calculations show that the transition state for the hydrogen atom abstraction by molecular oxygen along the pathway for the oxygenation reaction of (IMe)2(p-O2NC6H4CO2)PdH lies lower in energy with respect to the analogous transition state calculated for R=Ph.	Oxygen	243-249	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	320-323
18466326-6	2008	At the end of the period of oxygen and glucose deprivation, both cytochrome c and apoptosis-inducing factor translocated from mitochondria to cytosol.	Oxygen	28-34	cytochrome c, somatic	Homo sapiens	65-77
18596824-2	2008	VEGF-targeted therapies were initially developed with the notion that they would inhibit new blood vessel growth and thus starve tumours of necessary oxygen and nutrients.	Oxygen	150-156	vascular endothelial growth factor A	Homo sapiens	0-4
18636195-1	2008	D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death.	Oxygen	167-173	D-amino-acid oxidase	Rattus norvegicus	0-20
18636195-1	2008	D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death.	Oxygen	167-173	D-amino-acid oxidase	Rattus norvegicus	22-26
18710014-7	2008	Although we gave her O2 6 l x min(-1) after extubation, she showed low oxygen saturation (90%), thus we started bag-mask ventilation.	Oxygen	21-23	CD59 molecule (CD59 blood group)	Homo sapiens	30-36
18670636-3	2008	We have previously reported in established breast lines that HIF-1alpha levels in the presence of oxygen leads to the Warburg effect.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
18636206-12	2008	An oxygen- and time-dependent elevation of nuclear HIF-1alpha binding on HRE was displayed.	Oxygen	3-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
18298405-1	2008	Superoxide dismutase (SOD) is an enzymatic component of the antioxidant defense system that protects spermatozoa by catalysing the dismutation of superoxide anions to hydrogen peroxide and oxygen.	Oxygen	189-195	superoxide dismutase 3	Homo sapiens	22-25
18482580-3	2008	Ferrous CYP19 in Nanodiscs was mixed anaerobically in a rapid-scan stopped-flow with atmospheric dioxygen and the formation of the ferrous-oxy complex observed.	Oxygen	97-105	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	8-13
19115638-0	2008	[Expression of vascular endothelial growth factor and pigment epithelium derived factor in mouse oxygen-induced retinopathy and its significance].	Oxygen	97-103	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	54-87
19115638-1	2008	OBJECTIVE: To investigate the expression and significance of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in oxygen-induced mouse retinopathy.	Oxygen	151-157	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	107-140
19115638-1	2008	OBJECTIVE: To investigate the expression and significance of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in oxygen-induced mouse retinopathy.	Oxygen	151-157	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	142-146
18612512-1	2008	A long, two-electron ten-center (2e(-)/10c) [8 carbon plus 2 oxygen] bond in diamagnetic dimers of radical-anion tetracyano-1,4-benzoquinoneide (cyanil, [Q] (-)), [Q](2)(2-), is described by B3LYP and CASSCF(2,2)/MCQDPT calculations.	Oxygen	61-67	Rho GTPase activating protein 9	Homo sapiens	39-42
19040016-5	2008	The oxygen consumption at the anaerobic threshold (VO2AT) 3 months later of the exercise group was [(12.6 +/- 2.9) ml x min(-1) x kg(1)], significantly greater and that before the exercise [(10.5 x 2.9) ml x min x kg(-1), P = 0.000].	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	120-126
18635960-2	2008	The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) composed of HIF-1alpha and HIF-1beta, which becomes active under low oxygen condition.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-69
18635960-2	2008	The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) composed of HIF-1alpha and HIF-1beta, which becomes active under low oxygen condition.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
18591435-2	2008	Convincing evidence confirms a central role of hypoxia-inducible factor (HIF)-1 in mammalian oxygen homeostasis.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-79
18450754-2	2008	The direct oxygen sensor protein isolated from Escherichia coli (Ec DOS) is a heme-based signal transducer protein responsible for phosphodiesterase (PDE) activity.	Oxygen	11-17	phosphodiesterase	Escherichia coli	131-148
18450754-2	2008	The direct oxygen sensor protein isolated from Escherichia coli (Ec DOS) is a heme-based signal transducer protein responsible for phosphodiesterase (PDE) activity.	Oxygen	11-17	phosphodiesterase	Escherichia coli	150-153
18450754-3	2008	Binding of O(2), CO, or NO to a reduced heme significantly enhances the PDE activity toward 3",5"-cyclic diguanylic acid.	Oxygen	11-15	phosphodiesterase	Escherichia coli	72-75
18561900-1	2008	Recent experimental data have shown that hyperbaric oxygen therapy (HBOT) was associated increased Bcl-2 expression at the injury site that correlated with reduced apoptosis.	Oxygen	52-58	BCL2, apoptosis regulator	Rattus norvegicus	99-104
18547057-1	2008	The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5"-phosphate (PLP) enzyme DOPA decarboxylase (DDC) was here investigated.	Oxygen	12-18	dopa decarboxylase	Homo sapiens	113-131
18558410-0	2008	Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells.	Oxygen	11-17	placental growth factor	Homo sapiens	26-49
18366346-9	2008	We demonstrated that under moderate hypoxic conditions (1% O2) intracellular expression of cathepsin L was up-regulated.	Oxygen	59-61	cathepsin L	Homo sapiens	91-102
18457654-1	2008	Cytochrome c oxidase is a membrane-bound enzyme, which catalyses the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of O(2) to water.	Oxygen	161-165	cytochrome c, somatic	Homo sapiens	0-12
18515117-3	2008	The addition of SOD to a solution containing Cu(I)-glutathione led to a sustained decline of the basal oxygen level.	Oxygen	103-109	superoxide dismutase 1	Homo sapiens	16-19
19040016-6	2008	The peak oxygen uptake (VO2 pea) 3 months of the exercise group was (20 +/- 4) ml x min(-1) x kg(-1), signficantly greater then that before exercise [(14 +/- 4) ml x min(-1) x kg(-1), P = 0.000].	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	84-90
18514774-3	2008	Activated CD8+ T cells displayed an interferon (IFN)-gamma+ phenotype and enhanced by 1.8-fold the radiosensitivity of EMT-6 tumor cells in 1% oxygen, which modeled tumor-relevant hypoxia.	Oxygen	143-149	IL2 inducible T cell kinase	Mus musculus	119-122
18593917-5	2008	It was found that HIF-1alpha binds hARD1 through the oxygen-dependent degradation domain and, in so doing, dissociates hARD1 from beta-catenin, which prevents beta-catenin acetylation.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
18638657-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is critical not only in the regulation of oxygen homeostasis but also in the regulation of innate and adaptive immune systems.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
18638657-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is critical not only in the regulation of oxygen homeostasis but also in the regulation of innate and adaptive immune systems.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
18371179-7	2008	Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta.	Oxygen	59-65	tumor necrosis factor	Rattus norvegicus	124-133
18371179-7	2008	Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta.	Oxygen	59-65	interleukin 1 beta	Rattus norvegicus	138-146
18424433-1	2008	Oxygen-dependent ubiquitination of the alpha-subunit of hypoxia-inducible factor (HIF-alpha) by the (von Hippel-Lindau protein)-Elongin B/C-Cullin2-Rbx1 (VBC-Cul2) ubiquitin ligase, a member of the cullin-RING ubiquitin ligases (CRLs), plays a central role in controlling oxygen metabolism.	Oxygen	0-6	cullin 2	Homo sapiens	140-147
17941019-12	2008	In addition, perfusion culture at low oxygen (5%) enhanced the expansion of CD34+ cells and colony-forming activity compared to high oxygen (19%) cultures.	Oxygen	38-44	CD34 molecule	Homo sapiens	76-80
18384646-4	2008	In contrast, the excess release in response to 30 min combined oxygen and glucose deprivation was outside [Ca(2+)] independent, but still sensitive to the inhibition of both facilitatory P2X(1) and inhibitory P2Y(1) receptors.	Oxygen	63-69	purinergic receptor P2Y1	Rattus norvegicus	209-215
17913559-9	2008	The average dynamic O2 cost for protocol C (6.53 (+/-0.46) ml min(-1)W(-1)) was lower than that of protocol A (10.02 (+/-1.16) ml min(-1) W(-1)) and protocol B (10.03 (+/-0.91) ml min(-1) W(-1)).	Oxygen	20-22	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
18388202-4	2008	In this study, we examine the NO(2)(-)-dependent NO production in yeast engineered to contain alternative isoforms, Va or Vb, of Cco subunit V. Previous studies have shown that these isoforms have differential effects on oxygen reduction by Cco, and that their genes (COX5a and COX5b, respectively) are inversely regulated by oxygen.	Oxygen	221-227	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	278-283
18495282-7	2008	Catalase was used to disproportionate the formed hydrogen peroxide in close proximity to the oxygen consuming enzymes and applied in different amounts to adjust the hydrogen peroxide concentration, which was found to be the main reason for enzyme deactivation under turnover conditions.	Oxygen	93-99	catalase	Homo sapiens	0-8
18424433-1	2008	Oxygen-dependent ubiquitination of the alpha-subunit of hypoxia-inducible factor (HIF-alpha) by the (von Hippel-Lindau protein)-Elongin B/C-Cullin2-Rbx1 (VBC-Cul2) ubiquitin ligase, a member of the cullin-RING ubiquitin ligases (CRLs), plays a central role in controlling oxygen metabolism.	Oxygen	272-278	cullin 2	Homo sapiens	140-147
18462753-7	2008	These data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2"-phosphoryl moiety of NADP(+) and a threonine/lysine pair on ALDH(C).	Oxygen	105-111	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	188-192
18524954-10	2008	Exposure to hypoxia (&lt;1% O2) also suppresses CO2 avoidance via activation of the hypoxia-inducible transcription factor HIF-1.	Oxygen	28-30	Hypoxia-inducible factor 1	Caenorhabditis elegans	123-128
18417716-3	2008	Previous work from this laboratory demonstrated attenuation of postnatal retinal vascular development and retinal neovascularization during oxygen-induced ischemic retinopathy in bcl-2-deficient (bcl-2-/-) mice.	Oxygen	140-146	B cell leukemia/lymphoma 2	Mus musculus	179-184
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Oxygen	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18417716-3	2008	Previous work from this laboratory demonstrated attenuation of postnatal retinal vascular development and retinal neovascularization during oxygen-induced ischemic retinopathy in bcl-2-deficient (bcl-2-/-) mice.	Oxygen	140-146	B cell leukemia/lymphoma 2	Mus musculus	196-201
18378852-1	2008	Erythrocytosis can arise from deregulation of the erythropoietin (Epo) axis resulting from defects in the oxygen-sensing pathway.	Oxygen	106-112	erythropoietin	Homo sapiens	50-64
18441204-8	2008	The HNP-induced COX-2 and ET-1 production was attenuated by the treatment with the oxygen free radical scavenger N-acetyl-L-cysteine and the inhibitors of p38 MAPK and NF-kappaB, respectively.	Oxygen	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18441204-8	2008	The HNP-induced COX-2 and ET-1 production was attenuated by the treatment with the oxygen free radical scavenger N-acetyl-L-cysteine and the inhibitors of p38 MAPK and NF-kappaB, respectively.	Oxygen	83-89	endothelin 1	Homo sapiens	26-30
18359283-14	2008	Our results, and a structure model based on the crystal structures of the ferrous dioxygen complexes of P450(cam) and its T252A mutant, suggest that Asn252 can stabilize the ferric hydroperoxy intermediate, preventing premature release of H(2)O(2) and enabling addition of the second proton to the distal oxygen to generate the catalytic ferryl species.	Oxygen	84-90	calmodulin 3	Homo sapiens	104-113
18378852-1	2008	Erythrocytosis can arise from deregulation of the erythropoietin (Epo) axis resulting from defects in the oxygen-sensing pathway.	Oxygen	106-112	erythropoietin	Homo sapiens	66-69
18503213-6	2008	At 3 months after AMI, the number of CD34(+)/133(+) cells significantly correlated with oxygen consumption at the anaerobic threshold (p=0.002).	Oxygen	88-94	CD34 molecule	Homo sapiens	37-41
18334284-3	2008	By dissecting the impact of hypoxia-inducible factor 1 alpha on molecular responses, this review provides evidence for a powerful protecting role of oxygen deprivation against oxidative stress injury, androgen deprivation, chemotherapeutic and radiation cytotoxicity.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-60
18475156-6	2008	In multiple linear regression analysis controlling for confounding factors related with sleep apnea syndrome, high-sensitivity C-reactive protein was significantly correlated with 3% oxygen desaturation index (P = 0.047).	Oxygen	183-189	C-reactive protein	Homo sapiens	127-145
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	704-740
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	854-863
18343940-5	2008	The mouse model of oxygen-induced retinopathy consisted of a 5-day exposure to 75% oxygen from postnatal day 7 to 12 (P12) followed by 5 days in room air (relative hypoxia).	Oxygen	19-25	polymerase (DNA-directed), delta 4	Mus musculus	118-121
19099788-0	2008	[Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen].	Oxygen	108-114	serpin family E member 1	Rattus norvegicus	21-26
18566226-4	2008	The present study was designed to investigate whether low oxygen conditions might modulate HIF-1alpha expression through the Rho/ROCK signaling in human umbilical vascular ECs (HUVEC).	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
19099788-14	2008	(3) PAI-1 expression: From d 7 to 21 of oxygen exposure, PAI-1 protein expression (147.83 +/- 12.27, 149.07 +/- 11.17, 161.42 +/- 13.08) increased compared with the controls (116.18 +/- 10.67, 113.73 +/- 15.58, 126.60 +/- 8.59), P &lt; 0.01, &lt; 0.05 and &lt; 0.01, respectively.	Oxygen	40-46	serpin family E member 1	Rattus norvegicus	4-9
18359290-6	2008	Dose-dependent prosurvival effects of rapamycin were consistent with mTOR inhibition being a critical downstream mediator of AMPK in persistent low oxygen.	Oxygen	148-154	mechanistic target of rapamycin kinase	Homo sapiens	69-73
19099788-14	2008	(3) PAI-1 expression: From d 7 to 21 of oxygen exposure, PAI-1 protein expression (147.83 +/- 12.27, 149.07 +/- 11.17, 161.42 +/- 13.08) increased compared with the controls (116.18 +/- 10.67, 113.73 +/- 15.58, 126.60 +/- 8.59), P &lt; 0.01, &lt; 0.05 and &lt; 0.01, respectively.	Oxygen	40-46	serpin family E member 1	Rattus norvegicus	57-62
18239067-3	2008	Interestingly, those target genes are also hypoxia inducible and under the control of the oxygen-dependent transcription factor hypoxia-inducible factor (HIF)-1).	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-160
18264140-5	2008	HBx induced deacetylation of the oxygen-dependent degradation domain of HIF-1 alpha, which was accompanied with dissociation of prolyl hydroxylases and von Hippel-Lindau tumor suppressor from HIF-1 alpha.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-83
18264140-5	2008	HBx induced deacetylation of the oxygen-dependent degradation domain of HIF-1 alpha, which was accompanied with dissociation of prolyl hydroxylases and von Hippel-Lindau tumor suppressor from HIF-1 alpha.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	192-203
18513036-0	2008	Local reactivity of O2 with Pt3 on Co3Pt and related backgrounds.	Oxygen	20-22	zinc finger protein 135	Homo sapiens	28-31
18477695-0	2008	Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.	Oxygen	80-86	Hypoxia-inducible factor 1	Caenorhabditis elegans	16-21
18477695-2	2008	On a slower time scale, many cells respond to oxygen through the activity of the hypoxia-inducible transcription factor HIF-1.	Oxygen	46-52	Hypoxia-inducible factor 1	Caenorhabditis elegans	120-125
18477695-3	2008	Here, we show that in the nematode Caenorhabditis elegans, prolonged growth in hypoxia alters the neuronal circuit for oxygen preference by activating the hif-1 pathway.	Oxygen	119-125	Hypoxia-inducible factor 1	Caenorhabditis elegans	155-160
18477695-4	2008	Activation of hif-1 by hypoxia or by mutations in its negative regulator egl-9/prolyl hydroxylase shifts behavioral oxygen preferences to lower concentrations and eliminates a regulatory input from food.	Oxygen	116-122	Hypoxia-inducible factor 1	Caenorhabditis elegans	14-19
18477695-5	2008	At a neuronal level, hif-1 activation transforms a distributed, regulated neuronal network for oxygen preference into a smaller, fixed network that is constitutively active.	Oxygen	95-101	Hypoxia-inducible factor 1	Caenorhabditis elegans	21-26
18477695-6	2008	The hif-1 pathway acts both in neurons and in gonadal endocrine cells to regulate oxygen preference.	Oxygen	82-88	Hypoxia-inducible factor 1	Caenorhabditis elegans	4-9
18480265-1	2008	Superoxide dismutase 1 (SOD1) is an abundant copper/zinc enzyme found in the cytoplasm that converts superoxide into hydrogen peroxide and molecular oxygen.	Oxygen	149-155	superoxide dismutase 1	Homo sapiens	0-22
18480265-1	2008	Superoxide dismutase 1 (SOD1) is an abundant copper/zinc enzyme found in the cytoplasm that converts superoxide into hydrogen peroxide and molecular oxygen.	Oxygen	149-155	superoxide dismutase 1	Homo sapiens	24-28
18422316-5	2008	OxyL is a NADPH-dependent dioxygenase that introduces two oxygen atoms into 1 to yield the unstable intermediate 4-keto-ATC 2.	Oxygen	28-34	corin, serine peptidase	Homo sapiens	120-125
18160678-12	2008	These data support a functional role for GCM1 contributing to constitutively high trophoblast PGF expression and is the first direct evidence of an oxygen-responsive, trophoblast-specific transcription factor contributing to the regulation of PGF expression.	Oxygen	148-154	placental growth factor	Homo sapiens	243-246
18483329-1	2008	Catalase, a ubiquitous heme enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells from oxidative stress.	Oxygen	101-107	catalase	Homo sapiens	0-8
18073334-8	2008	In addition, stabilizing HIF1/2alpha by infecting mammalian cells with adenoviruses containing the oxygen-dependent degradation domain of HIF1alpha did not affect the plasma membrane Na-K-ATPase degradation.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-36
18073334-8	2008	In addition, stabilizing HIF1/2alpha by infecting mammalian cells with adenoviruses containing the oxygen-dependent degradation domain of HIF1alpha did not affect the plasma membrane Na-K-ATPase degradation.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-147
18243616-1	2008	Glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) have been established as being responsible for cellular adaptation to oxygen deficiency in tissue ischemia and hypoxia mediated by hypoxia-inducible factor 1.	Oxygen	146-152	vascular endothelial growth factor A	Homo sapiens	34-68
18243616-1	2008	Glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) have been established as being responsible for cellular adaptation to oxygen deficiency in tissue ischemia and hypoxia mediated by hypoxia-inducible factor 1.	Oxygen	146-152	vascular endothelial growth factor A	Homo sapiens	70-74
18410087-5	2008	2 oxidizes PPh 3 to SPPh3 and reacts with O2, generating several products, one of which has been identified as [(PhTt (tBu))Ni]2(mu-S) (3).	Oxygen	42-44	caveolin 1	Homo sapiens	11-16
18437152-10	2008	In contrast, catalase, which catalyzes the conversion of hydrogen peroxide to oxygen and water, inhibited neutrophil-endothelial adhesion in the preeclamptic group (8.1 +/- 0.5%, P &lt; 0.01).	Oxygen	78-84	catalase	Homo sapiens	13-21
18199003-5	2008	The transcription factor hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to reduced oxygen availability.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-51
18199003-5	2008	The transcription factor hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to reduced oxygen availability.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
18418234-2	2008	Multiple factors are thought to play a role in collateral development; however, the contribution of hypoxia inducible factor-1alpha (HIF-1alpha), which is a transcriptional activator that functions as a master regulator of oxygen homeostasis, is not completely clear.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-131
18418234-2	2008	Multiple factors are thought to play a role in collateral development; however, the contribution of hypoxia inducible factor-1alpha (HIF-1alpha), which is a transcriptional activator that functions as a master regulator of oxygen homeostasis, is not completely clear.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
18438213-6	2008	Oxygen consumption was significantly lower carrying the double-strap golf bag (L x min(-1), p = 0.0004; ml x kg(-1) x min(-1), p &lt; 0.0003), as were heart rate (p = 0.0013) and rate of perceived exertion (p &lt; 0.005) During the double strap trial, the perceived comfort was higher (p &lt; 0.005).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	83-89
18312373-4	2008	Pau5 is highly induced by low temperature, low oxygen and wine fermentation conditions.	Oxygen	47-53	seripauperin PAU5	Saccharomyces cerevisiae S288C	0-4
18572682-4	2008	The effects of the oxygen on the bonding configuration and electrical properties were investigated by adjusting TMS/O2 gas ratios.	Oxygen	19-25	PYD and CARD domain containing	Homo sapiens	112-115
18397321-2	2008	At 4 degrees C, the on-rate constants and off-rate constants of oxygen binding to PGIS in solution are 5.9 x 10(5) m(-1).s(-1) and 29 s(-1), respectively.	Oxygen	64-70	prostaglandin I2 synthase	Homo sapiens	82-86
18438213-6	2008	Oxygen consumption was significantly lower carrying the double-strap golf bag (L x min(-1), p = 0.0004; ml x kg(-1) x min(-1), p &lt; 0.0003), as were heart rate (p = 0.0013) and rate of perceived exertion (p &lt; 0.005) During the double strap trial, the perceived comfort was higher (p &lt; 0.005).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	118-124
18717335-1	2008	In present study, we investigated the mechanism of regulating HIF-1alpha expression by hydroxysafflor yellow A (HSYA) in Eahy 926 cell line under 1% O2 hypoxia.	Oxygen	149-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
18440561-1	2008	UNLABELLED: HIF-1 is a transcription factor that regulates genes involved in oxygen homeostasis.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-17
18440561-3	2008	For therapeutic angiogenesis purposes, HIF-1 alpha stabilization was previously achieved by either deleting its oxygen-dependent degradation domains, or introducing two proline point mutations at residues P402 and P564.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-50
18332128-1	2008	Hypoxia-inducible factor alpha (HIF-alpha) proteins are regulated by oxygen levels through several different mechanisms that include protein stability, transcriptional coactivator recruitment, and subcellular localization.	Oxygen	69-75	similar	Drosophila melanogaster	32-41
18225991-9	2008	EPO added at the time of reperfusion improved oxygen consumption when added to NP in comparison to static hypothermic storage but did not exert any other major benefits.	Oxygen	46-52	erythropoietin	Homo sapiens	0-3
18071747-0	2008	Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.	Oxygen	73-79	carbonic anhydrase 9	Rattus norvegicus	13-34
18283105-2	2008	Results demonstrate that exposure to high oxygen partial pressures increases synthesis of reactive species derived from type 2 nitric-oxide synthase and myeloperoxidase, leading to excessive S-nitrosylation of beta-actin and possibly profilin.	Oxygen	42-48	myeloperoxidase	Homo sapiens	153-168
18330983-11	2008	Thus, the Ni-S bond is protected from S-based oxygenation explaining the enhanced stability of the NiSOD active-site toward oxygenation by dioxygen.	Oxygen	139-147	solute carrier family 5 member 5	Homo sapiens	10-14
18417691-4	2008	Mitochondria from SOD1(G93A) rat astrocytes displayed a defective respiratory function, including decreased oxygen consumption, lack of ADP-dependent respiratory control, and decreased membrane potential.	Oxygen	108-114	superoxide dismutase 1	Rattus norvegicus	18-22
17973296-1	2008	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 that is the key regulator of cellular response to low oxygen tension.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
17973296-1	2008	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 that is the key regulator of cellular response to low oxygen tension.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
17973296-1	2008	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 that is the key regulator of cellular response to low oxygen tension.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-39
18405381-7	2008	Moreover, the use of PLB-985 granulocytes in which the NADPH oxidase is inactive due to the targeted disruption of a key component (gp91phox) revealed that NF-kappaB activation and kappaB-dependent responses are independent of endogenous reactive oxygen intermediates in these cells.	Oxygen	247-253	nuclear factor kappa B subunit 1	Homo sapiens	156-165
18410730-3	2008	Here, we show that extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor.	Oxygen	161-167	HIF prolyl hydroxylase	Drosophila melanogaster	134-140
17520326-0	2008	Oxygen dependence of tyrosine hydroxylase.	Oxygen	0-6	tyrosine hydroxylase	Homo sapiens	21-41
17520326-1	2008	The effects of dioxygen on tyrosine hydroxylase (TH) activity was studied, measuring the formation of DOPA from tyrosine, (3)H(2)O from 3,5-(3)H-tyrosine, or by direct oxygraphic determination of oxygen consumption.	Oxygen	15-23	tyrosine hydroxylase	Homo sapiens	27-47
17520326-1	2008	The effects of dioxygen on tyrosine hydroxylase (TH) activity was studied, measuring the formation of DOPA from tyrosine, (3)H(2)O from 3,5-(3)H-tyrosine, or by direct oxygraphic determination of oxygen consumption.	Oxygen	15-23	tyrosine hydroxylase	Homo sapiens	49-51
17520326-1	2008	The effects of dioxygen on tyrosine hydroxylase (TH) activity was studied, measuring the formation of DOPA from tyrosine, (3)H(2)O from 3,5-(3)H-tyrosine, or by direct oxygraphic determination of oxygen consumption.	Oxygen	17-23	tyrosine hydroxylase	Homo sapiens	27-47
17520326-1	2008	The effects of dioxygen on tyrosine hydroxylase (TH) activity was studied, measuring the formation of DOPA from tyrosine, (3)H(2)O from 3,5-(3)H-tyrosine, or by direct oxygraphic determination of oxygen consumption.	Oxygen	17-23	tyrosine hydroxylase	Homo sapiens	49-51
17520326-3	2008	During the initial reaction phase, apparent K (m)-values of 29-45 microM for dioxygen were determined for all human TH isoforms, i.e. 2-40 times higher than previously reported for TH isolated from animal tissues.	Oxygen	77-85	tyrosine hydroxylase	Homo sapiens	116-118
17520326-3	2008	During the initial reaction phase, apparent K (m)-values of 29-45 microM for dioxygen were determined for all human TH isoforms, i.e. 2-40 times higher than previously reported for TH isolated from animal tissues.	Oxygen	77-85	tyrosine hydroxylase	Homo sapiens	181-183
17520326-5	2008	Thus, TH activity may be severely limited by oxygen availability even at moderate hypoxic conditions, and the enzyme is rapidly and turnover dependent inactivated at the experimental conditions commonly employed to measure in vitro activities.	Oxygen	45-51	tyrosine hydroxylase	Homo sapiens	6-8
18452809-6	2008	Our study further demonstrates that as a result of Ca(2+)-DMP self-assembly, the distance between anionic oxygens between the two DMP molecules is reduced to 2.92A, which is in close agreement with the 2.8A SNARE-induced apposition established between opposing bilayers, reported earlier from X-ray diffraction measurements.	Oxygen	106-113	small NF90 (ILF3) associated RNA E	Homo sapiens	207-212
18371493-1	2008	In mitochondria and many aerobic bacteria cytochrome c oxidase is the terminal enzyme of the respiratory chain where it catalyses the reduction of oxygen to water.	Oxygen	147-153	cytochrome c, somatic	Homo sapiens	42-54
18338748-4	2008	The complexed hydrogen peroxide can then be degraded in the presence of catalase to form oxygen and water.	Oxygen	89-95	catalase	Homo sapiens	72-80
18385079-8	2008	RMVECs treated with 1% O2 had increased p-JNK compared with RMVECs exposed to room air.	Oxygen	23-25	mitogen-activated protein kinase 8	Homo sapiens	42-45
18384505-5	2008	These include blockade of reactive oxygen, resulting in decreased activation of NF-kappaB, which should sensitize tumors to chemotherapy and radiation.	Oxygen	35-41	nuclear factor kappa B subunit 1	Homo sapiens	80-89
18187198-1	2008	The oxygen atom transfer reactivity of Tp( *)MoO(2)(SPh) (1) (where Tp( *)=hydrotris-(3,5-dimethylpyrazol-1-yl)borate) with trimethyl phosphine (PMe(3)) has been investigated.	Oxygen	4-10	surfactant associated 3	Homo sapiens	52-55
17490458-1	2008	Our purpose was to determine the possible association between genotypes of three polymorphisms (Gly482Ser, Thr394Thr and A2962G) of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene, on one hand, and both the pre- (baseline) and post-training levels of maximal (i.e., maximal oxygen uptake [VO2max]) and submaximal human endurance capacity (i.e., running economy [RE]).	Oxygen	315-321	PPARG coactivator 1 alpha	Homo sapiens	136-204
17490458-1	2008	Our purpose was to determine the possible association between genotypes of three polymorphisms (Gly482Ser, Thr394Thr and A2962G) of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene, on one hand, and both the pre- (baseline) and post-training levels of maximal (i.e., maximal oxygen uptake [VO2max]) and submaximal human endurance capacity (i.e., running economy [RE]).	Oxygen	315-321	PPARG coactivator 1 alpha	Homo sapiens	206-214
18275186-3	2008	The potential catalytic effect of this type of interaction, with regard to P-OR bond cleavage, was investigated computationally through simple model systems in which an efficient intramolecular hydrogen bond can take place between a H-bond donor group and the bridging oxygen atom of the dianionic phosphate.	Oxygen	269-275	cytochrome p450 oxidoreductase	Homo sapiens	75-79
18622912-4	2008	Another promising treatment option is the VEGF-antibody bevacizumab, which blocks tumor-mediated angiogenesis leading to oxygen undersupply and finally growth inhibition of the tumor.	Oxygen	121-127	vascular endothelial growth factor A	Homo sapiens	42-46
18339855-2	2008	Hypoxia-inducible factor-1 (HIF-1) is the master regulator of both developmental and pathologic angiogenesis, composed of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-subunit.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
18339855-2	2008	Hypoxia-inducible factor-1 (HIF-1) is the master regulator of both developmental and pathologic angiogenesis, composed of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-subunit.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
18335029-4	2008	METHODOLOGY/PRINCIPAL FINDINGS: We illustrate here that NO produced by translocated nNOS (mtNOS) is the insulin-signaling molecule that controls mitochondrial oxygen utilization.	Oxygen	159-165	insulin	Homo sapiens	104-111
18335029-6	2008	At a precise concentration, insulin increased phospho-Akt2 that translocates to mitochondria and determines in situ phosphorylation and substantial cooperative mtNOS activation (+4-8 fold, P&lt;.05), high NO, and a lowering of mitochondrial oxygen uptake and resting metabolic rate (-25 to -60%, P&lt;.05).	Oxygen	241-247	insulin	Homo sapiens	28-35
17932373-4	2008	The mechanisms by which HIF modulates pro-inflammatory myeloid cell lifespan and function remain to be fully characterized, but roles for the oxygen-sensing hydroxylase enzymes through direct hydroxylation of NF-kappaB and its repressor protein IkappaBalpha have been suggested.	Oxygen	142-148	NFKB inhibitor alpha	Homo sapiens	245-257
17933562-7	2008	The genetic defects herein described are the first frameshift and nonsense mutations reported in the PHD2 gene and, as the previous missense mutation described, suggest that a decreased prolyl hydroxylase activity disturbing the oxygen-sensing pathway might be the cause of erythrocytosis.	Oxygen	229-235	egl-9 family hypoxia inducible factor 1	Homo sapiens	101-105
18361005-7	2008	The arginine vasopressin caused a decrease in cardiac output (3.8+/-1.1 vs. 2.7+/-0.7 l/min, P &lt;0.001) and mixed-venous oxygen tension (39.1+/-5.8 vs. 34.4+/-5 mmHg, P=0.003).	Oxygen	123-129	vasopressin	Sus scrofa	13-24
18164678-3	2008	The trigonal NO3- is coplanar with the Arg569 guanidinium group and mimics three of the four oxygen atoms of phosphate.	Oxygen	93-99	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
18077097-3	2008	In turn, LacCer activates an "oxygen-sensitive" signaling pathway involving superoxides, nitric oxide, p21 Ras GTP loading, kinase cascade, PI3kinase/Akt activation, nuclear factor up-regulation ultimately contributing to phenotypic changes such as cell proliferation, adhesion, migration and angiogenesis.	Oxygen	30-36	AKT serine/threonine kinase 1	Homo sapiens	150-153
18205324-0	2008	O2 binding to human serum albumin incorporating iron porphyrin with a covalently linked methyl-L-histidine isomer.	Oxygen	0-2	albumin	Homo sapiens	20-33
18205324-1	2008	We describe the significant difference in the O2 binding affinities of human serum albumin (HSA) incorporating 5,10,15,20-tetrakis{alpha,alpha,alpha,alpha- o-(1"-methylcyclohexanamido)phenyl}porphinatoiron(II) with a covalently linked 1-methyl-L-histidine or 3-methyl-L-histidine [HSA-FeP(1-MHis), HSA-FeP(3-MHis)].	Oxygen	46-48	albumin	Homo sapiens	77-90
18225859-2	2008	The Co(II) ion in the title compound is octahedrally coordinated by six phosphonate oxygen atoms from four carboxylate phosphonate ligands.	Oxygen	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18004559-1	2008	A major source of neurodegeneration observed in Alzheimer"s disease is believed to be caused by the toxicity from reactive oxygen species produced in the brain mediated by the A beta protein and mainly copper species.	Oxygen	123-129	amyloid beta precursor protein	Homo sapiens	176-182
18160046-1	2008	BACKGROUND: Hypoxia inducible factor 1 alpha (HIF-1A) is activated by low oxygen condition tension, a key regulator of the gene involved in the cellular response to hypoxia.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-44
18160046-1	2008	BACKGROUND: Hypoxia inducible factor 1 alpha (HIF-1A) is activated by low oxygen condition tension, a key regulator of the gene involved in the cellular response to hypoxia.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-52
18316597-9	2008	Our in vitro data displayed an elevated sensitivity to oxygen in Xpc(-/-) in mouse embryonic fibroblasts (MEF) when compared with Xpa(-/-) and wild-type fibroblasts.	Oxygen	55-61	xeroderma pigmentosum, complementation group C	Mus musculus	65-68
18316597-10	2008	We believe that XPC plays a role in the removal of oxidative DNA damage and that, therefore, Xpc(-/-) mice display a significant increase in lung tumors and a significant elevation in mutant frequency in lung, and Xpc-deficient MEFs show greater sensitivity to oxygen when compared with Xpa(-/-) and wild-type mice.	Oxygen	261-267	xeroderma pigmentosum, complementation group C	Mus musculus	16-19
18316597-10	2008	We believe that XPC plays a role in the removal of oxidative DNA damage and that, therefore, Xpc(-/-) mice display a significant increase in lung tumors and a significant elevation in mutant frequency in lung, and Xpc-deficient MEFs show greater sensitivity to oxygen when compared with Xpa(-/-) and wild-type mice.	Oxygen	261-267	xeroderma pigmentosum, complementation group C	Mus musculus	93-96
18350440-5	2008	In mice treated with oxygen, P2Y2 expression was detected in the ganglion and in the nerve fiber layers, whereas P2X2 expression was found in the inner and outer plexiform layers.	Oxygen	21-27	purinergic receptor P2Y, G-protein coupled 2	Mus musculus	29-33
18253865-2	2008	NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species.	Oxygen	176-182	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-32
18342758-7	2008	Presence of RLS did not correlate with measures of PH severity; however, patients with RLS were more likely to have a better 6-minute walk distance (p = 0.015) and lower BNP level (p = 0.07) and less likely to be WHO Class IV or require oxygen during the 6-minute walk test.	Oxygen	237-243	RLS1	Homo sapiens	87-90
18081811-10	2008	CONCLUSIONS: Reactive oxygen induced energy fuel gauge enzyme AMPKalpha expression and its activation by phosphorylation in RPC-C2A cells, suggesting that AMPK is essential for protection against H(2)O(2)-induced nonapoptotic cell death.	Oxygen	22-28	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-66
18496607-3	2008	The difference between the two lies in the insertion of the second oxygen atom, HMS directing this atom onto the benzylic carbon of the substrate while HPPD hydroxylates the aromatic C1 carbon.	Oxygen	67-73	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	152-156
18253865-2	2008	NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species.	Oxygen	176-182	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-38
18261897-3	2008	We show that DHEA decreased HIF-1alpha accumulation under both "chemical hypoxia" with treatment by the iron chelator deferroxamin and gas hypoxia (1% O2).	Oxygen	151-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
17920721-5	2008	The activity of SOD was down-regulated, but the activity of catalase was up-regulated by pyrogallol at 72 h. ROS scavengers, including Tempol, Tiron, Trimetazidine, and N-acetylcysteine (NAC), did not reduce the levels of the intracellular O2*-.	Oxygen	240-242	catalase	Homo sapiens	60-68
18164035-5	2008	RESULTS: Hepatocytes cultured in Matrigel with HepatoZyme medium at zone 1 and zone 3 oxygen conditions were viable for 1 wk and showed acute phase responses as measured by interleukin-6-induced fibrinogen production.	Oxygen	86-92	interleukin 6	Rattus norvegicus	173-186
18079996-6	2008	The magnitude of the postoperative increase in plasma MIF was associated with increased number of days required for mechanical ventilation (r = 0.553; P = 0.012), and peak plasma IL-8 correlated significantly with the fraction of inhaled oxygen (FiO(2)) required immediately after surgery (r = 0.510; P = 0.02).	Oxygen	238-244	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
18222538-4	2008	As assessed by Western analysis, the defective oxygen-dependent reduction of HIF-1alpha protein in villous explants from PE placenta was unaffected by the protein synthesis inhibitor, cycloheximide.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
18397606-6	2008	Hypoxia can trigger some of such changes and this has suggested that low oxygen tension at fiber level might be a mediator, possibly based on HIF and VEGF, of the muscle adaptation to increased contractile activity.	Oxygen	73-79	vascular endothelial growth factor A	Homo sapiens	150-154
18376310-3	2008	In addition, HIF-1alpha dependency was assessed by transiently transfecting MiaPaCa-2 pancreatic cancer cells with HIF-1alpha with a mutated oxygen degradation domain resulting in stable HIF-1alpha expression in normoxic conditions.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
18376310-3	2008	In addition, HIF-1alpha dependency was assessed by transiently transfecting MiaPaCa-2 pancreatic cancer cells with HIF-1alpha with a mutated oxygen degradation domain resulting in stable HIF-1alpha expression in normoxic conditions.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
18227840-4	2008	We used a model of human B cell lymphoma to show that tumor-specific T cells modified with this vector upregulate hIL-2 expression when oxygen tension is low in vitro and in vivo.	Oxygen	136-142	interleukin 2	Homo sapiens	114-119
18326315-2	2008	Epo is the major regulator of erythropoiesis, which is produced by kidneys with an inverse relation to oxygen availability.	Oxygen	103-109	erythropoietin	Homo sapiens	0-3
18222538-5	2008	However, after incubation with the proteasomal inhibitor, clasto-lactacystin, oxygen-dependent reduction of HIF-1alpha protein was markedly and similarly impaired in the villous explants from both normal and PE placentas.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
18222538-6	2008	Thus, impairment of protein degradation rather than increased synthesis causes inadequate oxygen-dependent reduction of HIF-1alpha protein in PE placentas.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
17590507-11	2008	More THBs were generated under degradation conditions without gases bubbling or adding any catalyst, and more DHBs under the condition of adding ferrous ion, and more carboxylic acids under the condition of oxygen-containing ozone gas bubbling.	Oxygen	207-213	thrombospondin 1	Homo sapiens	5-9
18241959-1	2008	The Catalase of Helicobacter pylori (H. pylori) helps bacteria to protect themselves from oxygen toxicity and damage and have been identified an immunodominant antigen.	Oxygen	90-96	catalase	Mus musculus	4-12
18287515-1	2008	Hypoxia inducible factor-1alpha (HIF-1alpha) is a key regulator of oxygen homeostasis, because it is responsible for the regulation of genes involved in glycolysis, erythropoiesis, angiogenesis, and apoptosis.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
18287515-1	2008	Hypoxia inducible factor-1alpha (HIF-1alpha) is a key regulator of oxygen homeostasis, because it is responsible for the regulation of genes involved in glycolysis, erythropoiesis, angiogenesis, and apoptosis.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
18183963-1	2008	During the analysis of surface-spotted analytes using desorption electrospray ionization-mass spectrometry (DESI-MS), abundant ions are sometimes observed that appear to be the result of oxygen addition reactions.	Oxygen	187-193	desumoylating isopeptidase 2	Homo sapiens	108-112
19039422-6	2008	The multiple regression lines had described two models to estimate the maximum oxygen consumption with the following average values: model 1 =48 ,46 +/-11,41 and model 2=46,83+/-11.11 ml/kg.min -1 .	Oxygen	79-85	CD59 molecule (CD59 blood group)	Homo sapiens	190-196
19039422-8	2008	The average results of the maximum oxygen consumption estimated for Group 2 model 1=48 ,14 +/-10,74 ml/kg.min -1 and model 2 =46,59+/-10,36 ml/kg.min -1 were not significantly different from the values observed in the effort test.	Oxygen	35-41	CD59 molecule (CD59 blood group)	Homo sapiens	106-112
18288196-7	2008	Thus, PGC-1alpha and ERR-alpha, major regulators of mitochondrial function in response to exercise and other stimuli, also control a novel angiogenic pathway that delivers needed oxygen and substrates.	Oxygen	179-185	estrogen related receptor, alpha	Mus musculus	21-30
18334941-4	2008	METHODS: C57BL/6 neonatal mice were exposed to a 75% concentration of oxygen from postnatal day 7 (P7) to P12 and returned to room air from P12 to P17 to induce retinal neovascularization.	Oxygen	70-76	polymerase (DNA-directed), delta 4	Mus musculus	106-109
18762723-2	2008	While oxygen availability regulates HIF-1 alpha by proteolytic degradation, some growth factors regulate HIF-1 alpha by protein synthesis in part through mammalian target of rapamycin complex 1 (TORC1) pathway.	Oxygen	6-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-47
17991881-4	2008	Here, we demonstrate that exposure of fetal pulmonary artery smooth muscle cells (FPASMCs) to high levels of oxygen for 24 hours leads to decreased responsiveness to exogenous NO, as determined by a decreased intracellular cGMP response, increased PDE5 mRNA and protein expression, as well as increased PDE5 cGMP hydrolytic activity.	Oxygen	109-115	phosphodiesterase 5A	Homo sapiens	248-252
17991881-4	2008	Here, we demonstrate that exposure of fetal pulmonary artery smooth muscle cells (FPASMCs) to high levels of oxygen for 24 hours leads to decreased responsiveness to exogenous NO, as determined by a decreased intracellular cGMP response, increased PDE5 mRNA and protein expression, as well as increased PDE5 cGMP hydrolytic activity.	Oxygen	109-115	phosphodiesterase 5A	Homo sapiens	303-307
18072750-3	2008	HIF-1 alpha can be activated by low oxygen concentrations and hypoxia-inducing agents.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
17991881-10	2008	These data suggest that PDE5 expression and activity play a critical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments for PPHN, such as oxygen and inhaled NO.	Oxygen	181-187	phosphodiesterase 5A	Homo sapiens	24-28
18187131-14	2008	The antiapoptotic protein Akt was also activated in cells exposed to hyperoxia, possibly reflecting a protective response to oxygen toxicity.	Oxygen	125-131	AKT serine/threonine kinase 1	Homo sapiens	26-29
18072750-5	2008	Here, we analyze the interference between the AhR signaling, activated by 10 nM 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), and the HIF-1 alpha pathway, induced by hypoxia (5% O2), in two human cell lines, the breast carcinoma cell line MCF-7 and the hepatocyte cell line HepG2.	Oxygen	177-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-144
18219391-2	2008	SOD1 is a cytosolic enzyme that facilitates the conversion of superoxide (O(2)(*-)) to H(2)O(2).	Oxygen	74-78	superoxide dismutase 1, soluble	Mus musculus	0-4
18357874-6	2008	RESULTS: In regard to surface roughness, average roughness for SB, SLA1 and SLA2 was obviously higher than S0 Oxygen ratio increased on SB,contrarily, it decreased on SLA.	Oxygen	110-116	Src like adaptor	Homo sapiens	67-70
18158356-7	2008	In conclusion, oxygen availability in the clipped kidney is maintained by angiotensin II generation, angiotensin II type 2 receptors, and NO synthase.	Oxygen	15-21	angiotensinogen	Rattus norvegicus	74-88
18158356-7	2008	In conclusion, oxygen availability in the clipped kidney is maintained by angiotensin II generation, angiotensin II type 2 receptors, and NO synthase.	Oxygen	15-21	angiotensinogen	Rattus norvegicus	101-115
18081797-7	2008	The normalisation of haemoglobin concentration by EPO in patients with CHF and CRI results in improved exercise capacity by increasing oxygen delivery and improving cardiac function.	Oxygen	135-141	erythropoietin	Homo sapiens	50-53
18219391-3	2008	Here we demonstrate that SOD1 is not just a catabolic enzyme, but can also directly regulate NADPH oxidase-dependent (Nox-dependent) O(2)(*-) production by binding Rac1 and inhibiting its GTPase activity.	Oxygen	133-137	superoxide dismutase 1, soluble	Mus musculus	25-29
17989353-3	2008	Here we show that treatment of neuronal cell line (SHSY-5Y) with antisense ORNs targeting the bcl-2 ARE (bcl-2 ARE asORNs) prevents bcl-2 down-regulation in response to apoptotic stimuli with glucose/growth factor starvation (Locke medium) or oxygen deprivation and enhances the apoptotic threshold as evaluated by time-lapse videomicroscopy, fluorescence-activated cell sorting analysis, and caspase-3 activation.	Oxygen	243-249	caspase 3	Homo sapiens	393-402
18376155-12	2008	Oxygen requirements for desired FiO2 and VE resulted in a mean oxygen usage of 3.24 L/min +/- 1.87 L/min (range, 1.6-10.2 L/min).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	86-95
18176562-2	2008	Here, we show that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP production through activation of a Pparalpha pathway.	Oxygen	39-45	peroxisome proliferator activated receptor alpha	Mus musculus	185-194
17989353-3	2008	Here we show that treatment of neuronal cell line (SHSY-5Y) with antisense ORNs targeting the bcl-2 ARE (bcl-2 ARE asORNs) prevents bcl-2 down-regulation in response to apoptotic stimuli with glucose/growth factor starvation (Locke medium) or oxygen deprivation and enhances the apoptotic threshold as evaluated by time-lapse videomicroscopy, fluorescence-activated cell sorting analysis, and caspase-3 activation.	Oxygen	243-249	BCL2 apoptosis regulator	Homo sapiens	94-99
17989353-3	2008	Here we show that treatment of neuronal cell line (SHSY-5Y) with antisense ORNs targeting the bcl-2 ARE (bcl-2 ARE asORNs) prevents bcl-2 down-regulation in response to apoptotic stimuli with glucose/growth factor starvation (Locke medium) or oxygen deprivation and enhances the apoptotic threshold as evaluated by time-lapse videomicroscopy, fluorescence-activated cell sorting analysis, and caspase-3 activation.	Oxygen	243-249	BCL2 apoptosis regulator	Homo sapiens	105-110
17989353-3	2008	Here we show that treatment of neuronal cell line (SHSY-5Y) with antisense ORNs targeting the bcl-2 ARE (bcl-2 ARE asORNs) prevents bcl-2 down-regulation in response to apoptotic stimuli with glucose/growth factor starvation (Locke medium) or oxygen deprivation and enhances the apoptotic threshold as evaluated by time-lapse videomicroscopy, fluorescence-activated cell sorting analysis, and caspase-3 activation.	Oxygen	243-249	BCL2 apoptosis regulator	Homo sapiens	105-110
18218341-2	2008	Abeta and amyloid-precursor protein are known to localize to mitochondrial membranes, block the transport of nuclear-encoded mitochondrial proteins to mitochondria, interact with mitochondrial proteins, disrupt the electron-transport chain, increase reactive oxygen species production, cause mitochondrial damage and prevent neurons from functioning normally.	Oxygen	259-265	amyloid beta precursor protein	Homo sapiens	10-35
18155142-3	2008	These changes in apoptosis and p53 expression are purported to result from exposure to altered oxygen tension.	Oxygen	95-101	tumor protein p53	Homo sapiens	31-34
18155142-4	2008	Using a model of villous trophoblast turnover, we examined the effect of 20%, 6% and 1% ambient oxygen (O(2)) on apoptosis, necrosis, proliferation and expression of p53 and related regulators of cell turnover, compared to both fresh tissue.	Oxygen	104-108	tumor protein p53	Homo sapiens	166-169
18155142-8	2008	The expression of p53, p21 and Mdm2 in both cytotrophoblast and stromal cells was increased following culture in 1% O(2).	Oxygen	116-120	tumor protein p53	Homo sapiens	18-21
18155142-11	2008	The potential role of the p53-pathway in the control of cell turnover in villous trophoblast and the regulation of p53 by altered O(2) tension merits further investigation.	Oxygen	130-134	tumor protein p53	Homo sapiens	115-118
18085260-3	2008	Using whole-body, continuous-flow plethysmography, we compared ventilatory responses to moderate hypoxia (10% inspired O2) of Sod1+/+, +/- and -/- postnatal day 4 (P4) littermates.	Oxygen	119-121	superoxide dismutase 1	Homo sapiens	126-130
17684492-2	2008	Here we investigated the potential relationship of oxygen-sensitive alpha-subunit of angiogenesis-related hypoxia-inducible factor-1alpha (HIF-1alpha) with Runt-related protein 1 (Runx1, also known as acute myeloid leukemia-1, AML-1), an important hematopoietic transcription factor.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
18190199-8	2008	The O2+ decays via dissociative recombination and either reacts with Ar resulting in electronically excited ArO or it recombines to O2 within the Ar cage.	Oxygen	4-7	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	108-111
18190199-8	2008	The O2+ decays via dissociative recombination and either reacts with Ar resulting in electronically excited ArO or it recombines to O2 within the Ar cage.	Oxygen	4-6	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	108-111
18516448-4	2008	RESULTS: Bilirubin decreased while aminotransferase activity increased 6 hours after BD (p&lt;0.01); TNFalpha determination at the 6th hour after BD was higher than the one at the 24th hour (p&lt;0.05); oxygen consumption in states 3 and 4 remained elevated in the BD initial phase , and liver cell damage worsened 24 hours after BD.	Oxygen	203-209	tumor necrosis factor	Rattus norvegicus	101-109
18290322-5	2008	Hypoxia-inducible factor (HIF)-1alpha, the master transcriptional regulator of the hypoxic response, as well as certain downstream genes, e.g., glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX, have been considered to be suitable as surrogate biomarkers of hypoxia due to their tight regulation by O2 levels under certain, well-defined in vitro conditions.	Oxygen	309-311	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
18190199-6	2008	Energy-resolved vis fluorescence spectra show the 2 1Sigma+--&gt;1 1Sigma+(ArO(1S)--&gt;ArO(1D)) transition from argon oxide as well as the vibrational progression A "3Delta u(nu"=0)--&gt;X 3Sigmag*(nu") of O2 indicating that molecular oxygen dissociates and occasionally recombines depending on the experimental conditions.	Oxygen	207-209	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	75-78
18190199-6	2008	Energy-resolved vis fluorescence spectra show the 2 1Sigma+--&gt;1 1Sigma+(ArO(1S)--&gt;ArO(1D)) transition from argon oxide as well as the vibrational progression A "3Delta u(nu"=0)--&gt;X 3Sigmag*(nu") of O2 indicating that molecular oxygen dissociates and occasionally recombines depending on the experimental conditions.	Oxygen	236-242	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	75-78
18190199-7	2008	Both the emission from ArO and O2 as well the vuv quenching by oxygen are found to depend on the excitation energy, providing evidence that the energy transfer from the photoexcited cluster to the embedded oxygen proceeds via the O2+ ground state.	Oxygen	206-212	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	23-26
18190199-7	2008	Both the emission from ArO and O2 as well the vuv quenching by oxygen are found to depend on the excitation energy, providing evidence that the energy transfer from the photoexcited cluster to the embedded oxygen proceeds via the O2+ ground state.	Oxygen	230-232	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	23-26
18171933-3	2008	When PP1 is inhibited pharmacologically or genetically, recovery from oxygen/glucose deprivation (OGD) in vitro, or ischemia in vivo is impaired.	Oxygen	70-76	inorganic pyrophosphatase 1	Homo sapiens	5-8
18290311-11	2008	These results suggest that Abeta interactions with RBCs in AD subjects can result in impaired oxygen transport and delivery, which will have important implications for AD.	Oxygen	94-100	amyloid beta precursor protein	Homo sapiens	27-32
19432205-6	2008	The age-related alterations in F, SOD, and GR stress responsiveness lead to activation of peroxide oxidation of lipids that may be considered as an important factor of aging damage of erythrocyte functioning and reliability of oxygen transport to tissues under stress conditions.	Oxygen	227-233	superoxide dismutase 1	Homo sapiens	34-37
18791271-4	2008	Here we provide a novel approach for HIF-1 targeted therapy using single-domain llama antibodies directed against the HIF-1alpha oxygen dependent degradation domain which encompass the N-terminal transactivation domain.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
17822384-11	2008	In conclusion, BNP appears to be part of the protective program steered by HIF-1 in response to oxygen deprivation.	Oxygen	96-102	natriuretic peptide B	Rattus norvegicus	15-18
19065037-13	2008	Furthermore, cytochrome C capacity to trap O(2) is reduced; this phenomenon alters the cellular redox potential and leads to the accumulation of electrons that induce the formation of ROS.This review presents an overview of the behaviour of endothelial cells face to hypoxia.	Oxygen	43-47	cytochrome c, somatic	Homo sapiens	13-25
17994289-7	2008	A VEGF response was elicited by cells exposed to low oxygen levels (20 mmHg), primarily within the construct core.	Oxygen	53-59	vascular endothelial growth factor A	Homo sapiens	2-6
18791271-4	2008	Here we provide a novel approach for HIF-1 targeted therapy using single-domain llama antibodies directed against the HIF-1alpha oxygen dependent degradation domain which encompass the N-terminal transactivation domain.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
18090356-13	2008	"At-risk" tissue defined by the physiologic region of interest, however, showed a universal increase in cerebral metabolic rate of oxygen from a median (interquartile range) of 23 (22-25) micromol x 100 mL(-1) x min(-1) to 30 (28-36) micromol x 100 mL(-1) x min(-1) (p &lt; .01).	Oxygen	131-137	CD59 molecule (CD59 blood group)	Homo sapiens	258-264
18090356-13	2008	"At-risk" tissue defined by the physiologic region of interest, however, showed a universal increase in cerebral metabolic rate of oxygen from a median (interquartile range) of 23 (22-25) micromol x 100 mL(-1) x min(-1) to 30 (28-36) micromol x 100 mL(-1) x min(-1) (p &lt; .01).	Oxygen	131-137	CD59 molecule (CD59 blood group)	Homo sapiens	212-218
18090670-4	2008	High oxygen consumption and hypoxia are thought to play important roles in progression of kidney disease, and angiotensin II and nitric oxide appear to influence oxygen consumption in these models.	Oxygen	162-168	angiotensinogen	Homo sapiens	110-124
18090362-14	2008	CONCLUSIONS: During the onset of sepsis, concurrent with the onset of microvascular dysfunction, there is an iNOS/NO-mediated reduction in local skeletal muscle tissue oxygen consumption.	Oxygen	168-174	nitric oxide synthase 2	Rattus norvegicus	109-113
18291025-10	2008	The hypoperfusion induced by AVP was associated with an increased systemic oxygen extraction.	Oxygen	75-81	vasopressin	Sus scrofa	29-32
18394182-2	2008	Intravenous vasopressor support, using 1 mg doses of epinephrine every 5 minutes in adults or vasopressin 40 IU, is recommended by American Heart Association Advanced Cardiac Life Support Guidelines to maximize oxygen delivery to the heart and brain and increase cellular high energy phosphate levels.	Oxygen	211-217	arginine vasopressin	Homo sapiens	94-105
18045551-1	2008	Hypoxia-inducible factor-1 (HIF-1), consisting of two subunits, HIF-1alpha and HIF-1beta, is a key regulator for adaptation to low oxygen availability, i.e., hypoxia.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17909095-10	2008	However, AgRP induced delayed and long-lasting modifications of energy balance in Pomc(-/-)Tg/+, but not glucocorticoid-deficient Pomc(-/-) mice, by decreasing oxygen consumption, increasing the respiratory exchange ratio, and increasing food intake.	Oxygen	160-166	agouti related neuropeptide	Mus musculus	9-13
19227238-0	2008	[Effect of endothelin-1 on the liver oxygen balance and heat production].	Oxygen	37-43	endothelin 1	Rattus norvegicus	11-23
18045551-1	2008	Hypoxia-inducible factor-1 (HIF-1), consisting of two subunits, HIF-1alpha and HIF-1beta, is a key regulator for adaptation to low oxygen availability, i.e., hypoxia.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
18195524-3	2008	We have studied the iron-mediated regulatory mechanism of a regulator of the iron metabolism, IRP2, and found that IRP2 is regulated by an oxidation-induced degradation, which is triggered by heme and molecular oxygen.	Oxygen	211-217	iron responsive element binding protein 2	Homo sapiens	115-119
17852555-6	2008	Oxygen increased considerably the inactivation of GAPDH and ADH.	Oxygen	0-6	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	50-55
19281089-11	2008	CONCLUSIONS: These findings indicate that physiological determinants of tissue oxygen availability are independently associated with CRP blood levels.	Oxygen	79-85	C-reactive protein	Homo sapiens	133-136
18071656-4	2008	This review focuses on the role(s) of TLR2 and Dectin-1 in triggering inflammatory responses, transcription factor activation, phagocytosis, and reactive oxygen production in response to fungi.	Oxygen	154-160	toll like receptor 2	Homo sapiens	38-42
19281089-0	2008	C-reactive protein correlates with tissue oxygen availability in patients with stable COPD.	Oxygen	42-48	C-reactive protein	Homo sapiens	0-18
19281089-3	2008	Tissue oxygen availability depends on arterial PaO2, oxygen concentration, hemoglobin oxygen affinity (P50), and hemoglobin oxygen binding capacity (ceHb).	Oxygen	7-13	nuclear factor kappa B subunit 1	Homo sapiens	103-106
17956952-13	2008	Lowered oxygen conditions promote sEng and sFlt-1, but reduce PlGF, productions by PE TCs.	Oxygen	8-14	placental growth factor	Homo sapiens	62-66
18050057-1	2008	Erythropoietin (EPO) promotes the production of red blood cells, the key factor in the regulation of the oxygen transport, and has been abused by athletes for performance enhancement in endurance sports.	Oxygen	105-111	erythropoietin	Homo sapiens	0-14
18050057-1	2008	Erythropoietin (EPO) promotes the production of red blood cells, the key factor in the regulation of the oxygen transport, and has been abused by athletes for performance enhancement in endurance sports.	Oxygen	105-111	erythropoietin	Homo sapiens	16-19
17541946-1	2008	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is a key determinant of oxygen-dependent gene regulation in angiogenesis.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
17541946-1	2008	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is a key determinant of oxygen-dependent gene regulation in angiogenesis.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-45
17925338-3	2008	DESIGN AND SUBJECTS: In 56 healthy young men (22.6 +/- 3.2 yr; 26.4 +/- 4.1 kg/m2) we determined insulin sensitivity by a euglycemic-hyperinsulinemic clamp, and whole body oxygen consumption and respiratory quotient by indirect calorimetry.	Oxygen	172-178	insulin	Homo sapiens	97-104
17956953-0	2008	Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity.	Oxygen	93-99	growth hormone 1	Homo sapiens	0-14
18575103-13	2008	TPI-N contained more oxygen-containing functional groups than the other fractions.	Oxygen	21-27	triosephosphate isomerase 1	Homo sapiens	0-3
19195551-7	2008	As a result of Ca(2+)-DMP self-assembly, the distance between anionic oxygens between the two DMP molecules is reduced to 2.92 A, which is in agreement with the 2.8 A SNARE-induced apposition established between opposing lipid bilayers, reported from X-ray diffraction measurements.	Oxygen	70-77	small NF90 (ILF3) associated RNA E	Homo sapiens	167-172
17939020-0	2008	Oxygen-dependent oxidation of Fe(II) to Fe(III) and interaction of Fe(III) with bovine serum albumin, leading to a hysteretic effect on the fluorescence of bovine serum albumin.	Oxygen	0-6	albumin	Homo sapiens	87-100
17939020-0	2008	Oxygen-dependent oxidation of Fe(II) to Fe(III) and interaction of Fe(III) with bovine serum albumin, leading to a hysteretic effect on the fluorescence of bovine serum albumin.	Oxygen	0-6	albumin	Homo sapiens	163-176
17384975-5	2008	We conclude that the photoinactivation of ACE with sequential 2-gamma irradiation involves reactive oxygen species produced by the interaction of the upper excited T(n) state of CuPcS(4) with molecular oxygen.	Oxygen	100-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-45
18268422-4	2008	Previous experimental and clinical studies detected changes in TNF circulating levels related to arterial oxygen (O2) saturation.	Oxygen	106-112	tumor necrosis factor	Homo sapiens	63-66
18268422-4	2008	Previous experimental and clinical studies detected changes in TNF circulating levels related to arterial oxygen (O2) saturation.	Oxygen	114-116	tumor necrosis factor	Homo sapiens	63-66
18268422-5	2008	The aim of the present study was to evaluate whether standard O2 hospital therapy affects plasma concentration of TNF-alpha in stable CHF patients.	Oxygen	62-64	tumor necrosis factor	Homo sapiens	114-123
18268422-8	2008	In these ten patients, the TNF-alpha plasma level increased after O2 compared to the basal condition (delta 5.47 +/- 1.72 pg/ml; P &lt; 0.05) whereas, in the same patients, the TNF-alpha plasma level did not change after the night with air (delta -0.05 +/- 3.03 pg/ml).	Oxygen	66-68	tumor necrosis factor	Homo sapiens	27-36
18268422-9	2008	A linear positive correlation (r = 0.62, P &lt; 0.01) between minutes of O2 saturation above 95% and TNF-alpha circulating differences from basal to post-O2 therapy was found.	Oxygen	73-75	tumor necrosis factor	Homo sapiens	101-110
18268422-9	2008	A linear positive correlation (r = 0.62, P &lt; 0.01) between minutes of O2 saturation above 95% and TNF-alpha circulating differences from basal to post-O2 therapy was found.	Oxygen	154-156	tumor necrosis factor	Homo sapiens	101-110
18268422-10	2008	CONCLUSIONS: Effective nocturnal hospital O2 therapy affects TNF-alpha plasma levels and the increase of TNF-alpha appears to be linearly related to the time of blood O2 saturation above 95%.	Oxygen	42-44	tumor necrosis factor	Homo sapiens	61-70
18268422-10	2008	CONCLUSIONS: Effective nocturnal hospital O2 therapy affects TNF-alpha plasma levels and the increase of TNF-alpha appears to be linearly related to the time of blood O2 saturation above 95%.	Oxygen	42-44	tumor necrosis factor	Homo sapiens	105-114
18268422-10	2008	CONCLUSIONS: Effective nocturnal hospital O2 therapy affects TNF-alpha plasma levels and the increase of TNF-alpha appears to be linearly related to the time of blood O2 saturation above 95%.	Oxygen	167-169	tumor necrosis factor	Homo sapiens	105-114
18374171-6	2008	Data show that Rho GTPases RhoA and Rac1 regulate pulmonary endothelial barrier function in response to changes in oxygen tension.	Oxygen	115-121	ras homolog family member A	Homo sapiens	27-31
18237625-1	2008	On delivery of nitric oxide (NO) to protein samples (e.g., cytochrome c"), for spectroscopic experiments it is important to avoid exposure to oxygen and to remove contaminants from the NO gas.	Oxygen	142-148	cytochrome c, somatic	Homo sapiens	59-71
18383347-6	2008	We conclude that treatment with GLP-2 attenuates intestinal I/R injury, reduces bacterial translocation, inhibits the release of oxygen free radicals and ET-1, and may well inhibit the production of proinflammatory cytokines.	Oxygen	129-135	mast cell protease 10	Rattus norvegicus	32-37
18039850-1	2008	Vascular endothelial growth factor (VEGF) is a key angiogenic factor expressed under restricted nutrient and oxygen conditions in most solid tumors.	Oxygen	109-115	vascular endothelial growth factor A	Homo sapiens	0-34
18039850-1	2008	Vascular endothelial growth factor (VEGF) is a key angiogenic factor expressed under restricted nutrient and oxygen conditions in most solid tumors.	Oxygen	109-115	vascular endothelial growth factor A	Homo sapiens	36-40
17942596-1	2008	Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes induced under low oxygen conditions.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17942596-1	2008	Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes induced under low oxygen conditions.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17942596-2	2008	Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
17942596-2	2008	Under normal oxygen conditions, HIF-1alpha, the active subunit of HIF-1, is hydroxylated on proline residues by specific HIF prolyl-hydroxylases, leading to ubiquitination and degradation by the proteasome.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
17942596-4	2008	Recent studies have shown that in normal oxygen conditions G-protein-coupled receptor agonists, including angiotensin (Ang) II and thrombin, potently induce and activate HIF-1 in vascular smooth muscle cells.	Oxygen	41-47	coagulation factor II, thrombin	Homo sapiens	131-139
17942596-4	2008	Recent studies have shown that in normal oxygen conditions G-protein-coupled receptor agonists, including angiotensin (Ang) II and thrombin, potently induce and activate HIF-1 in vascular smooth muscle cells.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	170-175
18391509-4	2008	Sixty minutes prior to the end of surgery, we kept a fixed 2% inspired isoflurane in 6,000 ml min(-1) oxygen flow.	Oxygen	102-108	CD59 molecule (CD59 blood group)	Homo sapiens	94-100
18451642-1	2008	Neuroglobin (Ngb) is a neuronal hemeprotein similar to myoglobin and hemoglobin and shares their capability for oxygen binding.	Oxygen	112-118	neuroglobin	Rattus norvegicus	0-11
18451642-1	2008	Neuroglobin (Ngb) is a neuronal hemeprotein similar to myoglobin and hemoglobin and shares their capability for oxygen binding.	Oxygen	112-118	neuroglobin	Rattus norvegicus	13-16
18451642-2	2008	It has thus been proposed that Ngb acts as an oxygen reservoir or combats reactive oxygen species.	Oxygen	46-52	neuroglobin	Rattus norvegicus	31-34
18487876-6	2008	RESULTS: Plasma adiponectin levels were negatively correlated with AHI, body mass index (BMI) and SpO(2) &lt;90% and positively correlated with minimum oxygen saturation.	Oxygen	152-158	adiponectin, C1Q and collagen domain containing	Homo sapiens	16-27
18220085-6	2008	MEASUREMENTS AND RESULTS: Markers of hypoxia (lowest oxygen saturation level and %T&lt;90), correlated significantly with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (Pearson"s r = -0.31 to -0.38, P &lt;0.003), while apnea hypopnea index, body mass index, blood pressure, fasting glucose, triglyceride, and cholesterol levels did not.	Oxygen	53-59	solute carrier family 17 member 5	Homo sapiens	122-148
19026021-2	2008	While the results are variable and sometimes inconsistent, and corroborating phenotypic data limited, carriers of the ACE "insertion" allele (the presence of an alu repeat element in intron 16 of the gene) have been reported to have higher maximum oxygen uptake (VO2max), greater response to training, and increased muscle efficiency when compared with individuals carrying the "deletion" allele (absence of the alu repeat).	Oxygen	248-254	angiotensin I converting enzyme	Homo sapiens	118-121
18230405-3	2008	Densitographic analyses of vWF multimer distribution also showed an inverse correlation between %HMW-multimers and oxygen saturation (r=-0.62, p=0.03).	Oxygen	115-121	von Willebrand factor	Homo sapiens	27-30
17666400-0	2007	Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
17320433-0	2008	Shifts in the haemoglobin-oxygen dissociation curve: can we manipulate P50 to good effect?	Oxygen	26-32	nuclear factor kappa B subunit 1	Homo sapiens	71-74
17666400-10	2007	Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
18044974-0	2007	Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila.	Oxygen	36-42	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	53-78
18001111-1	2007	The development of enzyme mimics of catalase which decompose hydrogen peroxide to water and molecular oxygen according to the 2:1 stoichiometry of native catalase and in aqueous solution at pH 7 and at micromolar concentrations of the enzyme model and hydrogen peroxide is reported.	Oxygen	102-108	catalase	Homo sapiens	36-44
18001111-1	2007	The development of enzyme mimics of catalase which decompose hydrogen peroxide to water and molecular oxygen according to the 2:1 stoichiometry of native catalase and in aqueous solution at pH 7 and at micromolar concentrations of the enzyme model and hydrogen peroxide is reported.	Oxygen	102-108	catalase	Homo sapiens	154-162
17965024-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of transcriptional responses to changes in O2 concentration.	Oxygen	100-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17965024-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of transcriptional responses to changes in O2 concentration.	Oxygen	100-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
18044974-2	2007	The heme cofactor in sGC does not bind oxygen, thereby allowing it to selectively bind NO despite a cellular concentration of oxygen (microM) that is much higher than signaling concentrations of nitric oxide (nM).	Oxygen	126-132	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	21-24
18044974-3	2007	The molecular details of this ligand discrimination against oxygen have emerged and allowed for predictions regarding ligand specificity in the sGC family.	Oxygen	60-66	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	144-147
18037122-6	2007	Mechanistically, amyloid-beta aggregates in mitochondria to impair function, leading to energy hypometabolism and elevated reactive oxygen species production.	Oxygen	132-138	amyloid beta precursor protein	Homo sapiens	17-29
17827022-4	2007	Hybrid 1 (O-2220) was found to have very high binding affinity to CB1 receptors (K(i)=8.5 nM), and it is interesting to note that the orientation of the side chain with respect to the oxygen in the phenol is the same as in THCs.	Oxygen	184-190	cannabinoid receptor 1	Homo sapiens	66-69
18050215-5	2007	Immunoblotting was conducted to evaluate intracellular protein levels of mPGES and nuclear accumulation of HIF-1alpha under different oxygen tension levels and with different stimulatory or inhibitory chemical agents.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
18036907-9	2007	The high-dose insulin therapy group had early extraction of lactate and higher oxygen extraction immediately postoperatively compared with the standard group.	Oxygen	79-85	insulin	Homo sapiens	14-21
17990984-4	2007	The HIFalpha hydroxylases belong to a superfamily of dioxygenases that require the co-substrates oxygen and 2-oxoglutarate as well as the cofactors Fe2+ and ascorbate.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-12
17725546-2	2007	The activity of these transcription factors is mainly determined by the stability of the HIFalpha subunit, which is regulated, in an oxygen-dependent manner, by a family of three prolyl 4-hydroxylases [EGLN1-EGLN3 (EGL nine homologues 1-3)].	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-97
17725546-2	2007	The activity of these transcription factors is mainly determined by the stability of the HIFalpha subunit, which is regulated, in an oxygen-dependent manner, by a family of three prolyl 4-hydroxylases [EGLN1-EGLN3 (EGL nine homologues 1-3)].	Oxygen	133-139	egl-9 family hypoxia inducible factor 1	Homo sapiens	202-207
17725546-3	2007	HIFalpha contains two, N- and C-terminal, independent ODDs (oxygen-dependent degradation domains), namely NODD and CODD, that, upon hydroxylation by the EGLNs, target HIFalpha for proteasomal degradation.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-8
17725546-3	2007	HIFalpha contains two, N- and C-terminal, independent ODDs (oxygen-dependent degradation domains), namely NODD and CODD, that, upon hydroxylation by the EGLNs, target HIFalpha for proteasomal degradation.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-175
17990984-7	2007	This recognition motif is present twice in HIF1alpha, which gives rise to a NODD [N-terminal ODD (oxygen-dependent degradation domain)] containing Pro402 of HIF1alpha and a CODD (C-terminal ODD) where Pro564 is hydroxylated.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-52
17990984-7	2007	This recognition motif is present twice in HIF1alpha, which gives rise to a NODD [N-terminal ODD (oxygen-dependent degradation domain)] containing Pro402 of HIF1alpha and a CODD (C-terminal ODD) where Pro564 is hydroxylated.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-166
17990984-11	2007	This elegant study improves our understanding of the interaction of the oxygen-sensing PHDs/EGLNs with their substrates, which include, but are not limited to, the HIFalpha proteins.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-172
18071267-6	2007	SOD possibly enhances the formation of the hydroxyl radical in reaction mixtures of photosensitizers that can produce O(2)(-.	Oxygen	118-122	superoxide dismutase 1	Homo sapiens	0-3
18071269-1	2007	The conditional ero1-1 mutant, deficient in the ER-localized PDI oxidase Ero1p, is blocked in disulfide bond formation under restrictive conditions, such as high temperature, lack of oxygen, or high concentrations of membrane-permeant thiols.	Oxygen	183-189	ER oxidoreductin	Saccharomyces cerevisiae S288C	16-22
18071269-1	2007	The conditional ero1-1 mutant, deficient in the ER-localized PDI oxidase Ero1p, is blocked in disulfide bond formation under restrictive conditions, such as high temperature, lack of oxygen, or high concentrations of membrane-permeant thiols.	Oxygen	183-189	ER oxidoreductin	Saccharomyces cerevisiae S288C	73-78
19002995-4	2007	Vascular endothelial growth factor (VEGF) is a major angiogenic factor in the formation of blood capillaries by cancer cells to supply nutrients and oxygen for their sustained growth.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	0-34
19002995-4	2007	Vascular endothelial growth factor (VEGF) is a major angiogenic factor in the formation of blood capillaries by cancer cells to supply nutrients and oxygen for their sustained growth.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	36-40
17609976-8	2007	The secretion of IL-6, leptin, MIF and VEGF from the adipocytes was also stimulated by exposure to 1% O(2).	Oxygen	102-106	interleukin 6	Homo sapiens	17-21
18026918-2	2007	This sensitivity has the merit of facilitating the kidneys in their adjustment of erythropoietin (EPO) production to changes in oxygen supply.	Oxygen	128-134	erythropoietin	Homo sapiens	82-96
18026918-2	2007	This sensitivity has the merit of facilitating the kidneys in their adjustment of erythropoietin (EPO) production to changes in oxygen supply.	Oxygen	128-134	erythropoietin	Homo sapiens	98-101
18026918-3	2007	The main determinant of EPO synthesis is the transcriptional activity of its gene in kidneys, which is related to local oxygen tensions.	Oxygen	120-126	erythropoietin	Homo sapiens	24-27
18026918-5	2007	When local oxygen tension decreases, accumulated HIF binds to the key sequence of the EPO gene, the hypoxia-responsive element (HRE), and activates transcription of EPO.	Oxygen	11-17	erythropoietin	Homo sapiens	86-89
18026918-5	2007	When local oxygen tension decreases, accumulated HIF binds to the key sequence of the EPO gene, the hypoxia-responsive element (HRE), and activates transcription of EPO.	Oxygen	11-17	erythropoietin	Homo sapiens	165-168
18026918-6	2007	HIF consists of a constitutive beta-subunit and one of alternative oxygen-regulated HIF alpha-subunits (HIF-1alpha, HIF-2alpha, and HIF-3alpha), and HIF-2alpha is responsible for erythropoietin production.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
18030436-1	2007	The hypoxia-inducible transcription factor (HIF-1alpha) is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
17898080-1	2007	The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of the cellular response to hypoxia.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-68
17898080-1	2007	The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of the cellular response to hypoxia.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
17609976-2	2007	Hypoxia led to a rapid and substantial increase (greater than sevenfold by 4 h of exposure to 1% O(2)) in the hypoxia-sensitive transcription factor, HIF-1alpha, in human adipocytes.	Oxygen	97-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-160
17609976-4	2007	Hypoxia (1% O(2) or CoCl(2)) led to a reduction (up to threefold over 24 h) in adiponectin and haptoglobin mRNA levels; adiponectin secretion also decreased.	Oxygen	12-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90
17609976-4	2007	Hypoxia (1% O(2) or CoCl(2)) led to a reduction (up to threefold over 24 h) in adiponectin and haptoglobin mRNA levels; adiponectin secretion also decreased.	Oxygen	12-16	haptoglobin	Homo sapiens	95-106
17609976-8	2007	The secretion of IL-6, leptin, MIF and VEGF from the adipocytes was also stimulated by exposure to 1% O(2).	Oxygen	102-106	vascular endothelial growth factor A	Homo sapiens	39-43
17609976-4	2007	Hypoxia (1% O(2) or CoCl(2)) led to a reduction (up to threefold over 24 h) in adiponectin and haptoglobin mRNA levels; adiponectin secretion also decreased.	Oxygen	12-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	120-131
18270190-5	2007	The risk of acute renal failure significantly increases for an oxygen delivery approximately at the same value (272 mL min(-1) m(- 2)).	Oxygen	63-69	CD59 molecule (CD59 blood group)	Homo sapiens	119-125
17944819-1	2007	The alternative oxidase (AOX) of plant mitochondria transfers electrons from the ubiquinione pool to oxygen without energy conservation and prevents the formation of reactive oxygen species (ROS) when the ubiquinone pool is over-reduced.	Oxygen	101-107	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	4-23
17944819-1	2007	The alternative oxidase (AOX) of plant mitochondria transfers electrons from the ubiquinione pool to oxygen without energy conservation and prevents the formation of reactive oxygen species (ROS) when the ubiquinone pool is over-reduced.	Oxygen	101-107	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	25-28
18046480-3	2007	Intersystem crossing to the triplet excited state (3HPPH*) competes with the electron transfer and 3HPPH* is quenched by oxygen to produce singlet oxygen (1O2), leading to specific covalent cross-linking of the nonactivated signal transducer and activator of transcription (STAT-3).	Oxygen	121-127	signal transducer and activator of transcription 3	Homo sapiens	274-280
18092379-8	2007	Plethysmographic oxygen saturation was the only parameter independently associated with AVP (regression coefficient, -0.126; 95% confidence interval, -0.237 to -0.014; P = 0.03).	Oxygen	17-23	arginine vasopressin	Homo sapiens	88-91
18336764-12	2007	The morning-evening difference of DBP was associated with AHI (r = -0.303, P = 0.011), amplitude of oxygen desaturation with pulse oxygen saturation (SpO(2)) less than 90% (OLA90%, r = -0.281, P = 0.018), and gradient of oxygen desaturation with SpO(2) less than 90% (OLG90%, r = 0.286, P = 0.035).	Oxygen	100-106	D-box binding PAR bZIP transcription factor	Homo sapiens	34-37
18046414-5	2007	In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption.	Oxygen	284-290	mechanistic target of rapamycin kinase	Homo sapiens	42-46
18046414-5	2007	In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption.	Oxygen	284-290	PPARG coactivator 1 alpha	Homo sapiens	145-189
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Oxygen	29-35	cytochrome c, somatic	Homo sapiens	133-145
17884817-3	2007	We report that low oxygen concentrations and TNFalpha enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 (HIF-1) to the 5" promoter region.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-149
17884817-3	2007	We report that low oxygen concentrations and TNFalpha enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 (HIF-1) to the 5" promoter region.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-156
18000055-4	2007	We found that in fetal pulmonary artery (PA) smooth muscle cells (SMC), fetal HIF-1 protein levels were O(2)-insensitive, whereas in adult PA SMC, hypoxia increased HIF-1 protein expression.	Oxygen	104-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-83
17901053-7	2007	Such results indicate the possibility that modulation of cellular Bach1 concentrations will have variable effects among the genes coordinately regulated by maf recognition/antioxidant response elements in iron/oxygen/antioxidant metabolism.	Oxygen	210-216	BTB domain and CNC homolog 1	Homo sapiens	66-71
17875644-1	2007	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of oxygen homeostasis that controls the expression of genes encoding proteins that play key roles in angiogenesis, erythropoiesis, and glucose/energy metabolism.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17875644-1	2007	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of oxygen homeostasis that controls the expression of genes encoding proteins that play key roles in angiogenesis, erythropoiesis, and glucose/energy metabolism.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17875644-3	2007	In aerobic cells, O(2)-dependent prolyl hydroxylation of HIF-1alpha is required for binding of the von Hippel-Lindau tumor suppressor protein VHL, which then recruits the Elongin C ubiquitin-ligase complex.	Oxygen	18-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
17702967-0	2007	Apolipoprotein E genotype and response of carbon monoxide poisoning to hyperbaric oxygen treatment.	Oxygen	82-88	apolipoprotein E	Homo sapiens	0-16
17998805-2	2007	These mutations invariably result in an inappropriate accumulation of HIF-alpha due to a failure of VHL as a substrate-recognition component of an E3 ubiquitin ligase complex to target HIFalpha for oxygen-dependent ubiquitin-mediated destruction.	Oxygen	198-204	hypoxia inducible factor 1 subunit alpha	Homo sapiens	185-193
17687652-7	2007	An ARX model was developed to accurately reproduce the measured oxygen uptake dynamics within the aerobic range.	Oxygen	64-70	aristaless related homeobox	Homo sapiens	3-6
17957310-8	2007	Furthermore, molecular oxygen significantly enhanced the extent of SO(2) uptake on alpha-Fe(2)O(3), as indicated by the greater than two-fold increase in the S2p : Fe2p ratio.	Oxygen	23-29	ribosomal protein S2	Homo sapiens	158-161
17704189-9	2007	Collectively, these results suggest that in alveolar macrophages, O(2)(*-) generation mediates chemokine expression after TNF-alpha stimulation in an ERK-dependent manner.	Oxygen	66-70	tumor necrosis factor	Homo sapiens	122-131
17704189-9	2007	Collectively, these results suggest that in alveolar macrophages, O(2)(*-) generation mediates chemokine expression after TNF-alpha stimulation in an ERK-dependent manner.	Oxygen	66-70	mitogen-activated protein kinase 1	Homo sapiens	150-153
17967948-5	2007	Here, we show that Erv1 passes its electrons on to molecular oxygen via interaction with cytochrome c and cytochrome c oxidase.	Oxygen	61-67	cytochrome c, somatic	Homo sapiens	89-101
17967948-5	2007	Here, we show that Erv1 passes its electrons on to molecular oxygen via interaction with cytochrome c and cytochrome c oxidase.	Oxygen	61-67	cytochrome c, somatic	Homo sapiens	106-118
17698984-2	2007	Insulin and meal feeding increase microvascular perfusion and thus oxygen, nutrient, and hormone delivery to human skeletal muscle.	Oxygen	67-73	insulin	Homo sapiens	0-7
17698984-12	2007	This insulin-mediated cardiac microvascular perfusion may play an important role in normal human myocardial oxygen and substrate physiology.	Oxygen	108-114	insulin	Homo sapiens	5-12
17720871-8	2007	After 6 h of HV(T) ventilation and LMBO, systemic arterial oxygen tension was higher in NOS2(-/-) than in wild-type mice (192 +/- 11 vs. 171 +/- 17 mmHg; P &lt; 0.05).	Oxygen	59-65	nitric oxide synthase 2, inducible	Mus musculus	88-92
18056950-4	2007	Maintenance of WI38 and IMR90 cells in 1.5% or 3% O(2) concentration significantly delayed the appearance of replicative senescence compared to cells grown in 20% O(2), induced the hypoxia-inducible factor-1alpha, and resulted in reduced expression levels of the key cell cycle modulators, namely p21 and p16.	Oxygen	50-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	181-212
17660267-6	2007	Insulin deprivation decreased muscle mitochondrial ATP production rate (MAPR) despite an increase in whole-body oxygen consumption and altered expression of many muscle mitochondrial gene transcripts.	Oxygen	112-118	insulin	Homo sapiens	0-7
18056950-4	2007	Maintenance of WI38 and IMR90 cells in 1.5% or 3% O(2) concentration significantly delayed the appearance of replicative senescence compared to cells grown in 20% O(2), induced the hypoxia-inducible factor-1alpha, and resulted in reduced expression levels of the key cell cycle modulators, namely p21 and p16.	Oxygen	50-54	cyclin dependent kinase inhibitor 2A	Homo sapiens	305-308
17720748-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O(2) in all metazoan species.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17720748-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O(2) in all metazoan species.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17880109-2	2007	This study was designed to evaluate the source of oxygen atoms in the covalent ester link in CYP4B1 enzymes labeled with [18O]glutamate and [18O]aspartate.	Oxygen	50-56	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	93-99
17997700-5	2007	Interaction of Abeta with Abeta-binding alcohol dehydrogenase (ABAD), a short-chain alcohol dehydrogenase in the mitochondrial matrix, leads to mitochondrial dysfunction evidenced by increased reactive oxygen species generation, mitochondrial membrane permeability formation and caspase-3-like activity induction, and decreased activities of the Krebs cycle.	Oxygen	202-208	amyloid beta precursor protein	Homo sapiens	15-20
17951900-1	2007	Wet age-related macular degeneration and diabetic retinopathy are pathological consequences of vascular endothelial growth factor (VEGF) release as a reaction to deficiency of oxygen and nutrients in the macular cells.	Oxygen	176-182	vascular endothelial growth factor A	Homo sapiens	95-129
17951900-1	2007	Wet age-related macular degeneration and diabetic retinopathy are pathological consequences of vascular endothelial growth factor (VEGF) release as a reaction to deficiency of oxygen and nutrients in the macular cells.	Oxygen	176-182	vascular endothelial growth factor A	Homo sapiens	131-135
17680990-2	2007	In addition, the possible involvement of Ras/extracellular-regulated kinase (ERK) ERK1/2 pathway in preserving cortical neurons exposed to oxygen and glucose deprivation (OGD) followed by reoxygenation was also examined.	Oxygen	139-145	mitogen-activated protein kinase 3	Homo sapiens	77-80
18047090-6	2007	The Si-Si/Si-O dehydrocoupling of 1 with AgNO3 even at dry nitrogen atmosphere is occurred, supporting that the oxidation of NO3- ion to NO2 is only the possible oxygen source, but not from the adventitious moisture in air.	Oxygen	162-168	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
17993959-1	2007	BACKGROUND: Hemoglobin-based oxygen carrier (HBOC) resuscitation has been associated with increased systemic and pulmonary vascular resistances (SVR, PVR), which may result in reduced blood flow and severe pulmonary hypertension.	Oxygen	29-35	PVR cell adhesion molecule	Sus scrofa	150-153
18095591-2	2007	METHODS: The HIBD model of SD rat was set up by ligating the right carotid artery and exposing the animals to 8% oxygen for 2.5 h. The dynamic change of CCR2 mRNA level was studied by using quantitative, real-time, fluorescence PCR assay (TaqMan), and the change of CCR2 protein was detected by SDS-PAGE assay.	Oxygen	113-119	C-C motif chemokine receptor 2	Rattus norvegicus	153-157
17717113-3	2007	Peak exercise and reserve Vo(2)(p), Q, and systemic arterial-venous oxygen difference (a-vO(2diff)) were 23-52% lower (P &lt; 0.05) in HTR.	Oxygen	68-74	telomerase RNA component	Homo sapiens	135-138
17717113-7	2007	The lower peak Vo(2)(p) and prolonged Vo(2)(p) kinetics in HTR were secondary to impairments in both cardiovascular and skeletal muscle function that result in reduced oxygen delivery and utilization by the active muscles.	Oxygen	168-174	telomerase RNA component	Homo sapiens	59-62
17625226-6	2007	Results indicate that the primary function of ferritin FtMt is not involved in storing cellular or body iron, but its association with cell types characterized by high metabolic activity and oxygen consumption suggests a role in protecting mitochondria from iron-dependent oxidative damage.	Oxygen	191-197	ferritin mitochondrial	Mus musculus	55-59
17785431-8	2007	The ability of Hap1 to function as a ligand-dependent repressor and activator is a property shared with mammalian nuclear hormone receptors and likely allows greater transcriptional control by Hap1 in response to changing oxygen levels.	Oxygen	222-228	huntingtin associated protein 1	Homo sapiens	15-19
17785431-8	2007	The ability of Hap1 to function as a ligand-dependent repressor and activator is a property shared with mammalian nuclear hormone receptors and likely allows greater transcriptional control by Hap1 in response to changing oxygen levels.	Oxygen	222-228	huntingtin associated protein 1	Homo sapiens	193-197
20507535-10	2007	Neither of the pathogens triggered cell death or accumulation of active oxygen species in dnd1-1.	Oxygen	72-78	Cyclic nucleotide-regulated ion channel family protein	Arabidopsis thaliana	90-94
18307948-6	2007	Under sufficient oxygen supply situation, HIF-1 alpha mRNA level was downregulated by pSUPER(H1-siHIF-1 alpha), but pSUPER(H1-siHIF-1 alpha) did not cause suppression of VEGF expression.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-53
17940602-7	2007	IFN-gamma and SP concentrations were lower in NPA from infants who required oxygen or mechanical ventilation.	Oxygen	76-82	interferon gamma	Homo sapiens	0-9
17880109-7	2007	These data demonstrate that the oxygen atom in 5-hydroxyheme derived from wild-type CYP4B1 originates in Glu310.	Oxygen	32-38	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	84-90
17952198-2	2007	Estimation of oxygen affinity of Hb from venous blood gas parameters (P50) revealed low P50 suggesting a high affinity Hb variant.	Oxygen	14-20	nuclear factor kappa B subunit 1	Homo sapiens	70-73
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	0-20
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	22-25
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	98-100	superoxide dismutase 1	Homo sapiens	0-20
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	98-100	superoxide dismutase 1	Homo sapiens	22-25
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	172-178	superoxide dismutase 1	Homo sapiens	0-20
19093460-2	2007	Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide (H2O2) and molecular oxygen (O2) thus providing a biological defense against oxygen toxicity.	Oxygen	172-178	superoxide dismutase 1	Homo sapiens	22-25
17942912-9	2007	Furthermore, LRP-1-silenced cells expressed decreased levels of vascular endothelial growth factor in response to 1.0% O2.	Oxygen	119-121	LDL receptor related protein 1	Homo sapiens	13-18
17942912-9	2007	Furthermore, LRP-1-silenced cells expressed decreased levels of vascular endothelial growth factor in response to 1.0% O2.	Oxygen	119-121	vascular endothelial growth factor A	Homo sapiens	64-98
17925579-4	2007	The hydroxylation reactions, which utilize O2 and alpha-ketoglutarate as substrates and generate CO2 and succinate as by-products, provide a mechanism by which changes in cellular oxygenation are transduced to the nucleus as changes in HIF-1 activity.	Oxygen	43-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	236-241
17916248-10	2007	Several globin genes are upregulated following oxygen deprivation and we find that HIF-1 and DAF-2 each are required for this response.	Oxygen	47-53	Hypoxia-inducible factor 1	Caenorhabditis elegans	83-88
17916248-10	2007	Several globin genes are upregulated following oxygen deprivation and we find that HIF-1 and DAF-2 each are required for this response.	Oxygen	47-53	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	93-98
17916248-16	2007	Ten globins are responsive to oxygen deprivation in an interacting HIF-1 and DAF-16 dependent manner.	Oxygen	30-36	Hypoxia-inducible factor 1	Caenorhabditis elegans	67-72
17952198-2	2007	Estimation of oxygen affinity of Hb from venous blood gas parameters (P50) revealed low P50 suggesting a high affinity Hb variant.	Oxygen	14-20	nuclear factor kappa B subunit 1	Homo sapiens	88-91
17696767-3	2007	Further, a role for mitochondrial dysfunction in AD is supported by studies of neurons from autopsy specimens of patients with AD, transgenic AD mice, and neuronal cells expressing human AD mutation, which have revealed that amyloid beta (Abeta) enters mitochondria early in the disease process and disrupts the electron-transport chain, generates reactive oxygen species, and inhibits the production of cellular ATP, which in turn prevents neurons from functioning normally.	Oxygen	357-363	amyloid beta precursor protein	Homo sapiens	225-237
17916722-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis and has essential roles in metazoan development, physiology, and disease pathogenesis.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17916722-2	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis and has essential roles in metazoan development, physiology, and disease pathogenesis.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17556672-0	2007	Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.	Oxygen	12-18	mechanistic target of rapamycin kinase	Homo sapiens	45-49
17556672-7	2007	Under 3% O(2), DEX decreased abundance of phosphorylated forms of the mTOR effectors, S6 kinase and ribosomal protein S6.	Oxygen	9-13	mechanistic target of rapamycin kinase	Homo sapiens	70-74
17644579-12	2007	Thus increases in eNOS and SOD-1 promote the coupling of oxygen delivery and efficiency in the heart during pregnancy.	Oxygen	57-63	superoxide dismutase 1	Canis lupus familiaris	27-32
17845207-11	2007	There is a significant negative correlation between the concentrations of MK and oxygen in FF, and a significant positive correlation between the concentrations of MK and estradiol.	Oxygen	81-87	midkine	Homo sapiens	74-76
17696767-3	2007	Further, a role for mitochondrial dysfunction in AD is supported by studies of neurons from autopsy specimens of patients with AD, transgenic AD mice, and neuronal cells expressing human AD mutation, which have revealed that amyloid beta (Abeta) enters mitochondria early in the disease process and disrupts the electron-transport chain, generates reactive oxygen species, and inhibits the production of cellular ATP, which in turn prevents neurons from functioning normally.	Oxygen	357-363	amyloid beta precursor protein	Homo sapiens	239-244
18080036-5	2007	In particular, diseases involving oxygen and nutrient deprivation, such as stroke, or diseases characterized by aggregate formation, such as Alzheimer"s and Huntington"s disease, could gain substantial benefit by either inhibiting or enhancing mTOR activity.	Oxygen	34-40	mechanistic target of rapamycin kinase	Homo sapiens	244-248
17881913-3	2007	We have shown that a mutation in a subunit, cytochrome b large subunit (SDHC), of complex II, also results in increasing O2 production and therefore leads to apoptosis and precocious aging in Caenorhabditis elegans.	Oxygen	121-123	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	72-76
17719234-5	2007	Experimental evidence suggests that O(2)(-*), which was directly observed in the APPI source, plays a key role in the formation of [M - H](-) ions by way of proton transfer.	Oxygen	36-40	amyloid beta precursor protein	Homo sapiens	81-85
20607138-7	2007	Some of the most ancient oxygen-sensing molecules, i.e., hypoxia-inducible factor-1alpha and erythropoietin, are up-regulated during mammalian lung development and growth under apparently normoxic conditions, suggesting functional evolution.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-88
20607138-7	2007	Some of the most ancient oxygen-sensing molecules, i.e., hypoxia-inducible factor-1alpha and erythropoietin, are up-regulated during mammalian lung development and growth under apparently normoxic conditions, suggesting functional evolution.	Oxygen	25-31	erythropoietin	Homo sapiens	93-107
17558516-9	2007	Correspondingly, oxygen cost of the work (38.8 +/- 13.9 ml min(-1) W(-1)) was found to be approximately 3.5 times higher.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	59-65
17495954-5	2007	Here, we demonstrate that the major oxygen-dependent HIF isoforms are strongly upregulated in psoriatic skin: HIF-1alpha mainly in the epidermis, in an expression pattern similar to VEGF mRNA; HIF-2alpha in both the epidermis and in capillary endothelial cells of the dermis.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
17445980-4	2007	The oxygen required for oxidation of ammonia might have been generated through catalase enzymatic activity of facultative anaerobes in mixed culture.	Oxygen	4-10	catalase	Homo sapiens	79-87
17445980-5	2007	The oxygen generation possibility by catalase enzyme route was demonstrated.	Oxygen	4-10	catalase	Homo sapiens	37-45
17495954-5	2007	Here, we demonstrate that the major oxygen-dependent HIF isoforms are strongly upregulated in psoriatic skin: HIF-1alpha mainly in the epidermis, in an expression pattern similar to VEGF mRNA; HIF-2alpha in both the epidermis and in capillary endothelial cells of the dermis.	Oxygen	36-42	vascular endothelial growth factor A	Homo sapiens	182-186
17634230-5	2007	Moreover, we have now determined that this association was dependent on the residues 46 to 89 of LANA and the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
17270495-4	2007	Significant differences were observed for the p50 values (the oxygen tension at which the haemoglobin is 50% saturated) between sedentary controls (25+/-1 mmHg) and either elite (26+/-1 mmHg; p&lt;0.01) or professional athletes (27+/-0.8; p&lt;0.01), whereas other conventional parameters of the venous blood-gas status (pH, P(O2), P(CO2) and saturation) did not differ significantly between the three study populations.	Oxygen	62-68	nuclear factor kappa B subunit 1	Homo sapiens	46-49
17270495-5	2007	Results of the present investigation suggest that intensive training may be associated with a right-shift of the standard oxygen dissociation curve, as attested by the increased p50.	Oxygen	122-128	nuclear factor kappa B subunit 1	Homo sapiens	178-181
17715198-6	2007	Itch ratings of the subjects were correlated with blood-oxygen-level-dependent (BOLD) effects.	Oxygen	56-62	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
17449336-3	2007	The distribution of O(2) between dissolved (PO2) and hemoglobin-bound (saturation) is the familiar oxygen equilibrium curve, whose position is noted as P50.	Oxygen	20-24	nuclear factor kappa B subunit 1	Homo sapiens	152-155
17879999-10	2007	These proteins have been reported with their important roles in microparticles in human blood cells: vWF is a platelet and endothelial cell product that binds to P-selectin, GP1b, and GP IIb/IIIa, and beta-globin is one of the peptides of hemoglobin involved in the transportation of oxygen by red blood cells.	Oxygen	284-290	von Willebrand factor	Homo sapiens	101-104
18246735-7	2007	Arterial oxygen saturation (SaO2) was negatively correlated (r=-0.625, p&lt;0.001) with VEGF, but not correlated with leptin (r=-0.207, p=0.211) in the cyanotic group.	Oxygen	9-15	vascular endothelial growth factor A	Homo sapiens	88-92
18007082-9	2007	CONCLUSION: Low concentration of thrombin precondition (TPC) can protect the astrocytes from oxygen-glucose deprived injury, and attenuate its apoptosis in a dose-dependent manner.	Oxygen	93-99	coagulation factor II	Rattus norvegicus	33-41
17449336-1	2007	Hemoglobin is involved in the regulation of O(2) transport in two ways: a long-term adjustment in red cell mass is mediated by erythropoietin (EPO), a response to renal oxgyenation.	Oxygen	44-48	erythropoietin	Homo sapiens	127-141
17449336-1	2007	Hemoglobin is involved in the regulation of O(2) transport in two ways: a long-term adjustment in red cell mass is mediated by erythropoietin (EPO), a response to renal oxgyenation.	Oxygen	44-48	erythropoietin	Homo sapiens	143-146
17449336-2	2007	Short-term, rapid-response adjustments are mediated by ventilation, cardiac output, hemoglobin oxygen affinity (P50), barriers to O(2) diffusion, and the control of local microvascular tissue perfusion.	Oxygen	95-101	nuclear factor kappa B subunit 1	Homo sapiens	112-115
17449336-3	2007	The distribution of O(2) between dissolved (PO2) and hemoglobin-bound (saturation) is the familiar oxygen equilibrium curve, whose position is noted as P50.	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	152-155
17449336-5	2007	However, more specialized species native to high altitudes (guinea pig and bar-headed goose, for example) seem to have a lower P50 than their sea level counterparts, an adaptation that presumably promotes O(2) uptake from a hypoxic environment.	Oxygen	205-209	nuclear factor kappa B subunit 1	Homo sapiens	127-130
17467346-4	2007	This led to an incredible increase in the understanding of the EPO-feedback-regulation loop at a molecular level, especially the oxygen-dependent EPO gene expression, a key function in the regulation loop.	Oxygen	129-135	erythropoietin	Homo sapiens	63-66
17662674-5	2007	Eicosapentaenoic acid depletion, products of lipid peroxidation (LP), as well as, lack of oxygen may combine in exacerbating activity of nuclear factor kappa B (NFkappaB), an ubiquitous pro-inflammatory and anti-apoptotic transcription factor.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	137-159
17662674-5	2007	Eicosapentaenoic acid depletion, products of lipid peroxidation (LP), as well as, lack of oxygen may combine in exacerbating activity of nuclear factor kappa B (NFkappaB), an ubiquitous pro-inflammatory and anti-apoptotic transcription factor.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	161-169
17698846-4	2007	In the presence of both L-arginine and tetrahydrobiopterin, eNOS is highly coupled (&gt;90%), and the measured stoichiometry of O(2)/NADPH is very close to the theoretical value.	Oxygen	128-132	nitric oxide synthase 3	Homo sapiens	60-64
17467346-4	2007	This led to an incredible increase in the understanding of the EPO-feedback-regulation loop at a molecular level, especially the oxygen-dependent EPO gene expression, a key function in the regulation loop.	Oxygen	129-135	erythropoietin	Homo sapiens	146-149
17698846-5	2007	We report for the first time that the presence of L-arginine stimulates oxygen uptake by eNOS.	Oxygen	72-78	nitric oxide synthase 3	Homo sapiens	89-93
17698846-8	2007	These results reveal different mechanisms for oxygen metabolism for eNOS as opposed to nNOS and, perhaps, partially explain their functional differences.	Oxygen	46-52	nitric oxide synthase 3	Homo sapiens	68-72
17521971-5	2007	The changes in O(2) diffusion to the tissues are discussed in relation to the expression of hypoxia inducible factor (HIF-1alpha) and vascular endothelial growth factor (VEGF) and their possible changes induced by training and/or hypoxic exposure.	Oxygen	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
17521971-5	2007	The changes in O(2) diffusion to the tissues are discussed in relation to the expression of hypoxia inducible factor (HIF-1alpha) and vascular endothelial growth factor (VEGF) and their possible changes induced by training and/or hypoxic exposure.	Oxygen	15-19	vascular endothelial growth factor A	Homo sapiens	134-168
17521971-5	2007	The changes in O(2) diffusion to the tissues are discussed in relation to the expression of hypoxia inducible factor (HIF-1alpha) and vascular endothelial growth factor (VEGF) and their possible changes induced by training and/or hypoxic exposure.	Oxygen	15-19	vascular endothelial growth factor A	Homo sapiens	170-174
17960110-13	2007	CONCLUSIONS: We conclude that NADH binding to lambda-crystallin enhances NADH photo-oxidation through a radical chain reaction mechanism that is initiated by superoxides generated by NADH photosensitization and propagated by another superoxide from the molecule oxygen.	Oxygen	262-268	lambda-crystallin	Oryctolagus cuniculus	46-63
17984939-10	2007	The difference between the evening and morning S100B levels correlated negatively with AHI and ODI and positively with basal saturation and average minimal oxygen saturation.	Oxygen	156-162	S100 calcium binding protein B	Homo sapiens	47-52
17664275-4	2007	NHE1 activity was significantly increased during 10-60 min reoxygenation (REOX) after 2-h oxygen and glucose deprivation (OGD).	Oxygen	61-67	solute carrier family 9 member A1	Homo sapiens	0-4
17960110-14	2007	High concentrations of NADH bound to lambda-crystallin may be beneficial to the rabbit lens in scavenging the low amounts of superoxide produced by near-UV absorption, since oxygen tension in the lens is very low.	Oxygen	174-180	lambda-crystallin	Oryctolagus cuniculus	37-54
17650504-5	2007	Stability of the oxy-ferrous complex in CYP3A4 and the amplitude of the geminate CO rebinding increased significantly as a result of binding of just one testosterone molecule.	Oxygen	17-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
17785842-7	2007	Delayed SAP injections also reduce the bleomycin-induced decrease in peripheral blood hemoglobin oxygen saturation, and an increase in lung collagen, leukocyte infiltration, and fibrosis.	Oxygen	97-103	amyloid P component, serum	Rattus norvegicus	8-11
17635920-7	2007	These results define a novel oxygen-sensing mechanism mediated by the combined actions of methylated intermediates in cholesterol synthesis and the hypoxia-activated transcription factor HIF-1alpha.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
17705494-0	2007	Genetic engineering of the heme pocket in human serum albumin: modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids.	Oxygen	77-79	albumin	Homo sapiens	48-61
17705494-1	2007	Complexing an iron protoporphyrin IX into a genetically engineered heme pocket of recombinant human serum albumin (rHSA) generates an artificial hemoprotein, which can bind O2 in much the same way as hemoglobin (Hb).	Oxygen	173-175	albumin	Homo sapiens	100-113
17624305-0	2007	The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-131
17624305-3	2007	We constructed here a novel HIF-1-dependent reporter gene, 5HREp-ODD-luc, in which 5 copies of the hypoxia-response element (5HRE) enhance expression of the oxygen-dependent degradation (ODD) domain and luciferase (luc) fusion under hypoxia.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17696490-0	2007	O2-binding albumin thin films: solid membranes of poly(ethylene glycol)-conjugated human serum albumin incorporating iron porphyrin.	Oxygen	0-2	albumin	Homo sapiens	89-102
17724133-9	2007	Hippocampal neurons from MyD88-5-deficient mice were protected from death after deprivation of oxygen and glucose.	Oxygen	95-101	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	25-32
17596326-8	2007	In mice with functional TLR4, the stress-induced increase in bactericidal activity was associated with a significant increase in macrophage gene expression for inducible nitric oxide synthase and subunits of the NADPH oxidase complex, which are responsible for generating reactive nitrogen and oxygen intermediates, respectively.	Oxygen	294-300	toll-like receptor 4	Mus musculus	24-28
17576198-6	2007	We detected a potent pathway that activated HIF-1 in the HTLV-1-infected T-cells under a normal oxygen concentration.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-49
17696490-1	2007	Poly(ethylene glycol) (PEG)-conjugated human serum albumin (HSA) incorporating the tetrakis(alpha,alpha,alpha,alpha-o-amidophenyl)porphinatoiron(II) derivative (FeP) [PEG(HSA-FeP)] is a unique plasma protein-based O2 carrier as a red blood cell substitute.	Oxygen	214-216	albumin	Homo sapiens	45-58
17658253-1	2007	A series of fluorinated diphenylchalcogen derivatives, possessing a sulfur or an oxygen bridge, has been prepared with the aim to get a suitable radiotracer to image the SERT in vivo using positron emission tomography (PET).	Oxygen	81-87	solute carrier family 6 member 4	Homo sapiens	170-174
17510660-5	2007	We report a higher level of COX activity, oxygen consumption and mitochondrial respiration in tumor cells overexpressing Bcl-2.	Oxygen	42-48	BCL2 apoptosis regulator	Homo sapiens	121-126
18457045-1	2007	Oxidatively-modified fibrinogen induces platelet aggregation and potentiates ADP-induced platelet aggregation and production of active oxygen forms in zymosan-stimulated leukocytes.	Oxygen	135-141	fibrinogen beta chain	Homo sapiens	21-31
17785204-4	2007	Ectopic expression of an oxygen-independent, stabilized HIF-1 mutant rescued lymphoma xenografts from inhibition by two antioxidants: N-acetylcysteine and vitamin C.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-61
17762611-4	2007	This very important observation indicates that hypoxia-inducible factor-1alpha is absolutely necessary for chondrocytes to survive extremely low oxygen tensions.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-78
17804701-0	2007	Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.	Oxygen	0-6	notch receptor 1	Homo sapiens	58-65
17896956-5	2007	On the basis of our previous studies on ischemia/reperfusion (I/R) in human cardiomyocytes it has become clear that severe hypoxic and ischemic stimuli evoke a mitochondrial response in terms of the functional adaptation of cyt c oxidase (COX) to oxygen altered availability.	Oxygen	247-253	cytochrome c, somatic	Homo sapiens	224-229
17896956-11	2007	These phenomena are strictly linked to the aforementioned ischemia-induced cyt c adaptive changes, for the reason that a primary imbalance is induced between the persistent down-regulated enzymatic oxidative capacity and mitochondrial oxygen gradients are rapidly restored.	Oxygen	235-241	cytochrome c, somatic	Homo sapiens	75-80
17467109-8	2007	Insulin sensitivity was negatively correlated with exercise tolerance (with anaerobic threshold, r=0.548; with peak oxygen uptake, r=0.581).	Oxygen	116-122	insulin	Homo sapiens	0-7
17467109-9	2007	Insulin sensitivity also showed significant positive correlation with cardiac function during exercise (GIR versus peak oxygen pulse: r=0.535).	Oxygen	120-126	insulin	Homo sapiens	0-7
17582597-9	2007	In the "inflammatory" scenario, p53, activated by DNA damage induced by oxygen and nitrogen species, recruits NF-kappaB to activate COX-2, resulting in antiapoptotic effects that contribute to cell expansion in inflammatory precursor lesions.	Oxygen	72-78	tumor protein p53	Homo sapiens	32-35
17825578-4	2007	In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium.	Oxygen	135-141	tumor necrosis factor	Homo sapiens	27-36
17825578-4	2007	In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium.	Oxygen	135-141	interleukin 1 beta	Homo sapiens	41-49
17937296-3	2007	delta(18)O of dissolved oxygen (DO) corroborates the delta(13)C(DIC) interpretation.	Oxygen	24-30	solute carrier family 25 member 10	Homo sapiens	64-67
17582597-9	2007	In the "inflammatory" scenario, p53, activated by DNA damage induced by oxygen and nitrogen species, recruits NF-kappaB to activate COX-2, resulting in antiapoptotic effects that contribute to cell expansion in inflammatory precursor lesions.	Oxygen	72-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-137
17458899-0	2007	Prostate carcinoma cells selected by long-term exposure to reduced oxygen tension show remarkable biochemical plasticity via modulation of superoxide, HIF-1alpha levels, and energy metabolism.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
17676847-1	2007	Photolysis of aqueous NO3(-) with lambda &gt; or = 195 nm is known to induce the formation of NO2(-) and O2 as the only stable products.	Oxygen	95-97	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
17521773-3	2007	Stimulatory effects of PACAP and VIP on cyclic AMP formation were significantly smaller in cell cultures subjected to 24h lasting hypoxic conditions, induced either chemically (100 microM cobalt chloride) or by low 3% oxygen hypoxia, compared to the normoxic condition (95% air and 5% CO(2)).	Oxygen	218-224	vasoactive intestinal peptide	Rattus norvegicus	33-36
17556599-8	2007	During this late exposure to 20% oxygen, bipotent glial (A2B5+) and early (platelet-derived growth factor receptor alpha) oligodendrocyte progenitors appeared and disappeared more quickly, relative to 5% oxygen, and late stage O4+ oligodendrocyte progenitors never appeared.	Oxygen	33-39	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	75-120
17610843-2	2007	Here, we show that HIF-1alpha undergoes post-translational modification by the three isoforms of the small ubiquitin-related modifier (SUMO-1, -2 and -3) in vitro in proximity to and within the oxygen-dependent degradation domain (ODDD).	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
17676735-6	2007	Together with our previously published Pd-H/O2 direct insertion mechanism, these reports provide a complete mapping of the possible pathways for reoxidation of palladium hydride with molecular oxygen.	Oxygen	193-199	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	39-46
17576767-3	2007	In addition, the block of respiration by antimycin A added to RLM respiring in state 4 conditions, or the addition of H2O2, results in O2 generation, which is blocked by the catalase inhibitors aminotriazole or KCN.	Oxygen	120-122	catalase	Rattus norvegicus	174-182
17676875-1	2007	The heme-containing respiratory protein, myoglobin (Mb), best known for oxygen storage, can exhibit peroxidase-like activity under conditions of oxidative stress.	Oxygen	72-78	myoglobin	Equus caballus	41-50
17655222-7	2007	However, for fac-Re(CO)3(DNS-dien), both chelate rings have the same pucker chirality because the sulfonamido ring has an unusual pucker for the absolute configuration at Re; a finding that is attributable to intramolecular and intermolecular hydrogen bonds from the sulfonamido oxygens to the NH2 groups.	Oxygen	279-286	FA complementation group C	Homo sapiens	13-16
18001528-6	2007	RESULTS: Compared with those of the intermittent normal oxygen group and blank control groups the ET-1 levels of the 4 IH sub groups were significantly higher (F = 28.453, P = 0.000), the NO levels ere significantly lower F = 65.252, P = 0.000), the NOS activity levels were significantly lower (F = 5.969, P = 0.008), and eNOS mRNA was significantly down-regulated (F = 16.630, P = 0.000).	Oxygen	56-62	endothelin 1	Homo sapiens	98-102
17675410-0	2007	Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.	Oxygen	10-18	arachidonate 15-lipoxygenase	Homo sapiens	45-63
17584741-7	2007	An even greater induction of AtNIP2;1 expression was observed upon anoxia challenge of Arabidopsis seedlings, with a 300-fold increase in AtNIP2;1 transcript observed by 2 h after the initiation of oxygen deprivation.	Oxygen	198-204	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	29-37
17584741-7	2007	An even greater induction of AtNIP2;1 expression was observed upon anoxia challenge of Arabidopsis seedlings, with a 300-fold increase in AtNIP2;1 transcript observed by 2 h after the initiation of oxygen deprivation.	Oxygen	198-204	NOD26-like intrinsic protein 2;1	Arabidopsis thaliana	138-146
17532579-0	2007	Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.	Oxygen	10-16	cytoglobin	Homo sapiens	110-120
17532579-1	2007	Several studies support the hypothesis that neuroglobin and cytoglobin play a protective role against cell death when cellular oxygen supply is critical.	Oxygen	127-133	cytoglobin	Homo sapiens	60-70
17636872-8	2007	The voltammetric behaviors of the three Abeta segments suggest that diffusion of oxygen to the metal center can be affected by the length and hydrophobicity of the Abeta peptide.	Oxygen	81-87	amyloid beta precursor protein	Homo sapiens	40-45
17675410-0	2007	Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.	Oxygen	12-18	arachidonate 15-lipoxygenase	Homo sapiens	45-63
17636872-8	2007	The voltammetric behaviors of the three Abeta segments suggest that diffusion of oxygen to the metal center can be affected by the length and hydrophobicity of the Abeta peptide.	Oxygen	81-87	amyloid beta precursor protein	Homo sapiens	164-169
17675410-3	2007	Choosing 12/15-lipoxygenase as a typical example for such oxygen-dependent enzymes, we determined the oxygen distribution within the protein and defined potential routes for oxygen access.	Oxygen	58-64	arachidonate 15-lipoxygenase	Homo sapiens	9-27
17558023-1	2007	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that functions as a master regulator of oxygen homeostasis.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17558023-1	2007	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that functions as a master regulator of oxygen homeostasis.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17558023-2	2007	The HIF-1alpha subunit is subjected to O(2)-dependent prolyl hydroxylation leading to ubiquitination by the von Hippel-Lindau protein (VHL)-Elongin C ubiquitin-ligase complex and degradation by the 26 S proteasome.	Oxygen	39-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
17675410-3	2007	Choosing 12/15-lipoxygenase as a typical example for such oxygen-dependent enzymes, we determined the oxygen distribution within the protein and defined potential routes for oxygen access.	Oxygen	58-64	arachidonate 15-lipoxygenase	Homo sapiens	9-27
17537429-2	2007	Atrial natriuretic peptide (ANP) actions are mediated by cGMP which is implicated in the metabolic adaptation of glucose metabolism to oxygen deprivation in the heart.	Oxygen	135-141	natriuretic peptide A	Homo sapiens	0-26
17507141-3	2007	The Lund University Cardiopulmonary Assist System (LUCAS) device is driven by &gt; 70 l min(-1) oxygen which is also likely to increase ambient oxygen concentrations and cause similar risk of fire and explosion.	Oxygen	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
17507141-3	2007	The Lund University Cardiopulmonary Assist System (LUCAS) device is driven by &gt; 70 l min(-1) oxygen which is also likely to increase ambient oxygen concentrations and cause similar risk of fire and explosion.	Oxygen	144-150	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
17562539-2	2007	Tumors expressing hypoxia-inducible factor-1alpha (HIF-1alpha), an important transcriptional activator of oxygen-regulated genes, are resistant to chemotherapy and radiotherapy.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-49
17562539-2	2007	Tumors expressing hypoxia-inducible factor-1alpha (HIF-1alpha), an important transcriptional activator of oxygen-regulated genes, are resistant to chemotherapy and radiotherapy.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
17486142-6	2007	Uncoupling of eNOS (one electron transfer to molecular oxygen, the second substrate of eNOS) during ischemia-reperfusion due to diminished availability of L-arginine and/or tetrahydrobiopterin is even discussed as one major source of superoxide formation.	Oxygen	55-61	nitric oxide synthase 3	Homo sapiens	14-18
17486142-6	2007	Uncoupling of eNOS (one electron transfer to molecular oxygen, the second substrate of eNOS) during ischemia-reperfusion due to diminished availability of L-arginine and/or tetrahydrobiopterin is even discussed as one major source of superoxide formation.	Oxygen	55-61	nitric oxide synthase 3	Homo sapiens	87-91
17629795-8	2007	The levels of TNF-alpha, IL-6, and KC in BAL fluid were increased after oxygen exposure, which was suppressed by the lack of TLR4 signaling.	Oxygen	72-78	tumor necrosis factor	Mus musculus	14-23
17629795-8	2007	The levels of TNF-alpha, IL-6, and KC in BAL fluid were increased after oxygen exposure, which was suppressed by the lack of TLR4 signaling.	Oxygen	72-78	interleukin 6	Mus musculus	25-29
17629795-8	2007	The levels of TNF-alpha, IL-6, and KC in BAL fluid were increased after oxygen exposure, which was suppressed by the lack of TLR4 signaling.	Oxygen	72-78	toll-like receptor 4	Mus musculus	125-129
17394531-5	2007	Additionally, we tested the hypothesis that mutant SOD1 increases mitochondrial-produced superoxide (O(2) (*)) levels and that SOD2 overexpression protects neurons from mutant SOD1-induced toxicity by reducing O(2) (*) levels in mitochondria.	Oxygen	101-105	superoxide dismutase 1	Homo sapiens	51-55
17394531-5	2007	Additionally, we tested the hypothesis that mutant SOD1 increases mitochondrial-produced superoxide (O(2) (*)) levels and that SOD2 overexpression protects neurons from mutant SOD1-induced toxicity by reducing O(2) (*) levels in mitochondria.	Oxygen	210-214	superoxide dismutase 1	Homo sapiens	176-180
17394531-7	2007	Utilizing the mitochondrial-targeted O(2) (*)-sensitive fluorogenic probe MitoSOX Red, we observed a significant increase in mitochondrial O(2) (*) levels in neural cells expressing mutant SOD1.	Oxygen	37-41	superoxide dismutase 1	Homo sapiens	189-193
17394531-7	2007	Utilizing the mitochondrial-targeted O(2) (*)-sensitive fluorogenic probe MitoSOX Red, we observed a significant increase in mitochondrial O(2) (*) levels in neural cells expressing mutant SOD1.	Oxygen	139-143	superoxide dismutase 1	Homo sapiens	189-193
17394531-9	2007	These data suggest that mitochondrial-produced O(2) (*) radicals play a critical role in mutant SOD1-mediated neuronal toxicity and implicate mitochondrial-produced free radicals as potential therapeutic targets in ALS.	Oxygen	47-51	superoxide dismutase 1	Homo sapiens	96-100
17689698-0	2007	Hemoglobin-based oxygen carrier induces hepatic heme oxygenase 1 expression in Kupffer cells.	Oxygen	17-23	heme oxygenase 1	Mus musculus	48-64
17689698-3	2007	A hemoglobin-based oxygen carrier (HBOC) has been shown to prevent organ inflammation from hemorrhagic shock as well as induce HO-1 at the cellular level.	Oxygen	19-25	heme oxygenase 1	Mus musculus	127-131
17702269-6	2007	In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI.	Oxygen	122-124	C-reactive protein	Homo sapiens	13-16
17702269-6	2007	In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI.	Oxygen	169-171	C-reactive protein	Homo sapiens	13-16
21162257-3	2007	RESULTS: In the group of a 12 h long exposure to oxygen concentration of 0%, diazoxide (100 micromol/L), the K(ATP) channels agonist, reduced p53 expression and the hypoxia-induced apoptosis.	Oxygen	49-55	tumor protein p53	Homo sapiens	142-145
17537429-2	2007	Atrial natriuretic peptide (ANP) actions are mediated by cGMP which is implicated in the metabolic adaptation of glucose metabolism to oxygen deprivation in the heart.	Oxygen	135-141	natriuretic peptide A	Homo sapiens	28-31
17564434-1	2007	The properties of Cu(II) and Co(II) complexes with oxygen- or nitrogen-containing macrocycles have been extensively studied; however, less attention has been paid to the study of complexes containing sulfur atoms in the first coordination sphere.	Oxygen	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
17923015-11	2007	HES130/0.4 lowers the S100B protein levels from the beginning of CPB to one hour after the termination of CPB with the probable mechanism of improving the cerebral metabolism of oxygen.	Oxygen	178-184	S100 calcium binding protein B	Homo sapiens	22-27
17510190-14	2007	Uterine artery O(2) delivery in these pregnancies was 99 +/- 3 ml min(-1), approximately 5-fold greater than near-term fetal O(2) consumption.	Oxygen	15-19	CD59 molecule (CD59 blood group)	Homo sapiens	66-72
17567269-9	2007	The SIN-1-induced improvement in the P(CO(2)) gap was accompanied by an increase in serosal muP(O(2)) above shock levels.	Oxygen	40-44	MAPK associated protein 1	Homo sapiens	4-9
17612411-0	2007	Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes.	Oxygen	36-42	Dual oxidase	Drosophila melanogaster	73-77
17558293-3	2007	Rises of [Ca2+]i evoked by bradykinin, and subsequent capacitative Ca2+ entry, were enhanced by prior hypoxia (1% O2, 24 h) without effect on reduced glutathione levels.	Oxygen	114-116	kininogen 1	Homo sapiens	27-37
17442736-10	2007	Our results show that GLUTs are upregulated by hypoxia via a HIF-1-mediated pathway in trophoblast cells and suggest that the GLUT response to hypoxia in vivo will be determined not only by low oxygen tension but also by other factors that modulate HIF-1 levels.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
17329595-7	2007	Oxygen-regulated expression of LDHA and SLC2A1 in bovine blastocysts suggests that regulation of these genes may be mediated by HIF2.	Oxygen	0-6	L-lactate dehydrogenase A chain	Bos taurus	31-35
16973170-0	2007	Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice.	Oxygen	19-25	apolipoprotein E	Mus musculus	103-107
17679571-6	2007	Bottled oxygen delivered at 2 L x min(-1) via nasal cannula was prescribed for her journey.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	34-40
17630596-5	2007	It is proposed that the kidneys detect small changes in tissue oxygen tension for erythropoietin production at the critmeter, a functional unit of marginal oxygen tension within the kidneys.	Oxygen	63-69	erythropoietin	Homo sapiens	82-96
17630596-5	2007	It is proposed that the kidneys detect small changes in tissue oxygen tension for erythropoietin production at the critmeter, a functional unit of marginal oxygen tension within the kidneys.	Oxygen	156-162	erythropoietin	Homo sapiens	82-96
17907405-1	2007	Oxygen reduction in a photosynthetic electron-transport chain (PETC) was studied in isolated pea thylakoids in the presence of either ferredoxin, or ferredoxin + NADP+, or cytochrome c.	Oxygen	0-6	cytochrome c, somatic	Homo sapiens	172-184
17907405-4	2007	However, the absolute rate of oxygen reduction by membrane components of PETC in the presence of NADP+ was 3-4 times less than that in the presence of ferredoxin alone and close to the rate of oxygen reduction in the presence of cytochrome c.	Oxygen	30-36	cytochrome c, somatic	Homo sapiens	229-241
17907405-4	2007	However, the absolute rate of oxygen reduction by membrane components of PETC in the presence of NADP+ was 3-4 times less than that in the presence of ferredoxin alone and close to the rate of oxygen reduction in the presence of cytochrome c.	Oxygen	193-199	cytochrome c, somatic	Homo sapiens	229-241
17503097-0	2007	Locally enhanced sampling molecular dynamics study of the dioxygen transport in human cytoglobin.	Oxygen	58-66	cytoglobin	Homo sapiens	86-96
17846000-6	2007	Angiogenesis is stimulated by vascular endothelial growth factor (VEGF), a HIF target gene, to increase blood flow towards oxygen-deprived tissues.	Oxygen	123-129	vascular endothelial growth factor A	Homo sapiens	30-64
17846000-6	2007	Angiogenesis is stimulated by vascular endothelial growth factor (VEGF), a HIF target gene, to increase blood flow towards oxygen-deprived tissues.	Oxygen	123-129	vascular endothelial growth factor A	Homo sapiens	66-70
17371947-5	2007	Consistent with the role of GSK3b in destabilizing beta-catenin, there was more cytoplasmic beta-catenin in UC-HPCs exposed to 2% to 3% O(2) on fibronectin, compared with suspension culture.	Oxygen	136-140	fibronectin 1	Homo sapiens	144-155
17371947-6	2007	UC-HPCs cultured at 2% to 3% O(2) with OB factors showed an increase in nuclear beta-catenin and persistence of a small pool of CD34(+)38(-) HPCs.	Oxygen	29-33	CD34 molecule	Homo sapiens	128-132
17544543-5	2007	PKB/Akt activity was increased by low oxygen concentrations in kidney cells, and insulin-stimulated activation of PKB/Akt was stronger, more rapid and more sustained in hypoxia.	Oxygen	38-44	AKT serine/threonine kinase 1	Homo sapiens	0-3
17544543-5	2007	PKB/Akt activity was increased by low oxygen concentrations in kidney cells, and insulin-stimulated activation of PKB/Akt was stronger, more rapid and more sustained in hypoxia.	Oxygen	38-44	AKT serine/threonine kinase 1	Homo sapiens	4-7
17544543-5	2007	PKB/Akt activity was increased by low oxygen concentrations in kidney cells, and insulin-stimulated activation of PKB/Akt was stronger, more rapid and more sustained in hypoxia.	Oxygen	38-44	insulin	Homo sapiens	81-88
17502492-8	2007	Renal oxygen consumption and acetate turnover varied on a wide range from 0.05 to 0.29 mmol min(-1) (&gt;5-fold) and from 0.025 to 0.188 minutes(-1) (&gt;7-fold), respectively.	Oxygen	6-12	CD59 molecule (CD59 blood group)	Homo sapiens	92-98
17607360-1	2007	Erythrocyte precursors produce abundant alpha- and beta-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier.	Oxygen	148-154	hemoglobin alpha chain complex	Mus musculus	112-124
17607360-1	2007	Erythrocyte precursors produce abundant alpha- and beta-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier.	Oxygen	148-154	hemoglobin alpha chain complex	Mus musculus	126-129
17503097-4	2007	In this paper, the results of 60 ns molecular dynamics (MD) simulations of dioxygen diffusion inside Cyg matrix are discussed.	Oxygen	75-83	cytoglobin	Homo sapiens	101-104
17503097-10	2007	Implications of efficient oxygen transport found in Cyg to its possible physiological role are discussed.	Oxygen	26-32	cytoglobin	Homo sapiens	52-55
17590070-7	2007	Mean average oxygen flow rate was 1.00 +/- 0.17 L x min(-1).	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	52-58
17434750-2	2007	HIF prolyl hydroxylases (PHDs) control HIF-1 accumulation by hydroxylation dependent on molecular oxygen.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
17913962-5	2007	Compared to vehicle control, increasing concentrations of ET-1 reduce by 3- to 6-fold the level of apoptosis in cytotrophoblasts exposed to serum-free conditions at 20% oxygen.	Oxygen	169-175	endothelin 1	Homo sapiens	58-62
17913962-7	2007	ET-1 significantly reduces apoptosis in cultures exposed to 20% oxygen but not in cultures exposed to 8% or 1% oxygen.	Oxygen	64-70	endothelin 1	Homo sapiens	0-4
17913962-8	2007	The effect of ET-1 on apoptosis in 20% oxygen is accompanied by reduced p53 expression and is correlated with enhanced expression of endothelin B receptor, compared to cultures in 8% or 1% oxygen.	Oxygen	39-45	endothelin 1	Homo sapiens	14-18
17913962-8	2007	The effect of ET-1 on apoptosis in 20% oxygen is accompanied by reduced p53 expression and is correlated with enhanced expression of endothelin B receptor, compared to cultures in 8% or 1% oxygen.	Oxygen	39-45	tumor protein p53	Homo sapiens	72-75
17913962-8	2007	The effect of ET-1 on apoptosis in 20% oxygen is accompanied by reduced p53 expression and is correlated with enhanced expression of endothelin B receptor, compared to cultures in 8% or 1% oxygen.	Oxygen	39-45	endothelin receptor type B	Homo sapiens	133-154
17462608-0	2007	Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia.	Oxygen	34-40	endothelin 1	Rattus norvegicus	59-71
17536854-1	2007	Mammalian inducible nitric oxide synthase (iNOS) catalyzes the production of l-citrulline and nitric oxide (NO) from L-arginine and O2.	Oxygen	132-134	nitric oxide synthase 2	Homo sapiens	10-41
17536854-1	2007	Mammalian inducible nitric oxide synthase (iNOS) catalyzes the production of l-citrulline and nitric oxide (NO) from L-arginine and O2.	Oxygen	132-134	nitric oxide synthase 2	Homo sapiens	43-47
17384064-6	2007	On the other hand, when the electrostatic interaction brings the positively charged groups of K-8 and K-28 into the vicinity of the carbonyl oxygen atoms of the inner leaflet lipids, the system exhibits a deep binding mode.	Oxygen	141-147	keratin 28	Homo sapiens	102-106
17512464-3	2007	The generation of ROS by FMLP-activated neutrophils was monitored according to the magnitude of oxygen consumption and autoiodination, while spectrofluorimetric procedures were used to measure alterations in membrane potential and influx of Ca(2+).	Oxygen	96-102	formyl peptide receptor 1	Homo sapiens	25-29
17687397-5	2007	RESULTS: bFGF could protect some signal transduction proteins from the oxygen-derived free radicals induced degradation.	Oxygen	71-77	fibroblast growth factor 2	Homo sapiens	9-13
17418478-3	2007	We describe a mathematical model for O(2) transport by hemoglobin solutions and red blood cells flowing through arteriolar-sized tubes to optimize values of p50, Hill number, hemoglobin molecular diffusivity and concentration.	Oxygen	37-41	nuclear factor kappa B subunit 1	Homo sapiens	157-160
17329402-2	2007	A growing body of evidence suggests that an additional target for NO is the mitochondrial oxygen-consuming heme/copper enzyme, cytochrome c oxidase.	Oxygen	90-96	cytochrome c, somatic	Homo sapiens	127-139
17893997-1	2007	The transcription factor hypoxia-inducible factor (HIF)-1 plays a central physiological role in oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the subunit HIF-1alpha.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-57
17893997-1	2007	The transcription factor hypoxia-inducible factor (HIF)-1 plays a central physiological role in oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the subunit HIF-1alpha.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
17418478-7	2007	The model predicts that regardless of size, hemoglobin solutions with higher p50 will present excess O(2) to arteriolar walls.	Oxygen	101-105	nuclear factor kappa B subunit 1	Homo sapiens	77-80
17400550-1	2007	Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor sensitive to oxygen levels, which responds to stress factors under both hypoxic and nonhypoxic conditions.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17400550-1	2007	Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor sensitive to oxygen levels, which responds to stress factors under both hypoxic and nonhypoxic conditions.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17879147-0	2007	Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers" most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.	Oxygen	193-199	hexokinase 2	Equus caballus	16-28
17551816-1	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17562881-0	2007	Myoglobin-enhanced oxygen delivery to isolated cardiac mitochondria.	Oxygen	19-25	myoglobin	Equus caballus	0-9
17551816-1	2007	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17562881-7	2007	We conclude that, in normal steady states of contraction of the myoglobin-containing heart, oxygen utilization by mitochondrial cytochrome oxidase is not limited by oxygen availability.	Oxygen	92-98	myoglobin	Equus caballus	64-73
17498258-2	2007	SIRT1 overexpression reduces the level of oxygen consumption, which is correlative with nonalcoholic fatty liver disease (NAFLD).	Oxygen	42-48	sirtuin 1	Rattus norvegicus	0-5
17513437-1	2007	Nitric oxide (NO) is synthesized from arginine and O2 by NO synthase (NOS).	Oxygen	51-53	nitric oxide synthase 2	Homo sapiens	57-68
17558861-1	2007	AIMS AND METHODS: Hypoxia-inducible factor (HIF-1) which contains oxygen regulated HIF-1alpha subunit maintains cytoprotective defence against hypoxic injury by induction of numerous genes.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-49
17558861-1	2007	AIMS AND METHODS: Hypoxia-inducible factor (HIF-1) which contains oxygen regulated HIF-1alpha subunit maintains cytoprotective defence against hypoxic injury by induction of numerous genes.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
17512623-10	2007	Glut1 and LDH-A had a similar expression pattern to each other, with a maximum expression at 0.01% oxygen, in both cell lines.	Oxygen	99-105	lactate dehydrogenase A	Homo sapiens	10-15
17146432-1	2007	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
17467020-1	2007	For many decades it has been thought that oxygen analogs (oxons) of organophosphorus insecticides phosphorylate the catalytic site of acetylcholinesterase by a mechanism that follows simple Michaelis-Menten kinetics.	Oxygen	42-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-154
17501870-1	2007	Manipulation of the blood"s oxygen carrying capacity (CaO(2)) through reinfusion of red blood cells, injections of recombinant erythropoietin or by other means results in an increased maximal oxygen uptake and concomitantly enhanced endurance performance.	Oxygen	28-34	erythropoietin	Homo sapiens	127-141
17501870-1	2007	Manipulation of the blood"s oxygen carrying capacity (CaO(2)) through reinfusion of red blood cells, injections of recombinant erythropoietin or by other means results in an increased maximal oxygen uptake and concomitantly enhanced endurance performance.	Oxygen	192-198	erythropoietin	Homo sapiens	127-141
18160990-1	2007	Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body"s response to low oxygen concentrations, or hypoxia.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
17146432-1	2007	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
17488012-0	2007	Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.	Oxygen	32-40	nitric oxide synthase 2	Homo sapiens	54-75
17374610-11	2007	Our findings indicate that transcription of the NTRK2 gene is stimulated at low oxygen tension through a HIF-1-dependent mechanism.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
17284667-0	2007	Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia.	Oxygen	45-47	Multidrug resistance protein 4	Drosophila melanogaster	11-16
17284667-4	2007	In this screen, we identified Drosophila CG14709 gene as a homolog of the human multidrug resistance protein 4 (MRP4/ABCC4) that is tightly regulated to oxygen.	Oxygen	153-159	Multidrug resistance protein 4	Drosophila melanogaster	41-48
17284667-6	2007	When exposed to 4% oxygen chronically (throughout its lifespan), constitutive expression of dMRP4 in larvae caused larval lethality due to growth arrest.	Oxygen	19-25	Multidrug resistance protein 4	Drosophila melanogaster	92-97
17284667-9	2007	Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O(2) deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O(2) in the whole organism.	Oxygen	107-111	Multidrug-Resistance like Protein 1	Drosophila melanogaster	39-42
17284667-9	2007	Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O(2) deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O(2) in the whole organism.	Oxygen	107-111	Multidrug resistance protein 4	Drosophila melanogaster	55-60
17284667-9	2007	Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O(2) deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O(2) in the whole organism.	Oxygen	107-111	Multidrug-Resistance like Protein 1	Drosophila melanogaster	55-59
17284667-9	2007	Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O(2) deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O(2) in the whole organism.	Oxygen	202-206	Multidrug-Resistance like Protein 1	Drosophila melanogaster	39-42
17436234-7	2007	Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy.	Oxygen	189-195	interleukin 6	Homo sapiens	10-28
17436234-7	2007	Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy.	Oxygen	189-195	interferon gamma	Homo sapiens	43-65
17362885-2	2007	In organotypic hippocampal slice cultures, we demonstrate that incubation with low doses of thrombin protects neurons against a subsequent severe oxygen and glucose deprivation.	Oxygen	146-152	coagulation factor II	Mus musculus	92-100
17411073-0	2007	Interplay of oxygen, vitamin E, and carotenoids in radical reactions following oxidation of Trp and Tyr residues in native HDL3 apolipoproteins.	Oxygen	13-19	HDL3	Homo sapiens	123-127
17476338-5	2007	After 1-day exposure to low oxygen, MSCs increased in vitro migration in response to the fractalkine and SDF-1alpha in a dose dependent manner.	Oxygen	28-34	C-X3-C motif chemokine ligand 1	Homo sapiens	89-100
17485712-7	2007	Average 50-cm depth soil solution NO3- and ground water dissolved oxygen (DO) explained 64% of average cropland ground water NO3- variability.	Oxygen	66-72	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
17437619-2	2007	Glutathione-S-transferases (GSTs) are detoxification enzymes, evolved to protect cells against reactive oxygen metabolites.	Oxygen	104-110	glutathione S-transferase mu 1	Homo sapiens	28-32
17456219-6	2007	RESULTS: NAC (0.1-1 mm) inhibited the extracellular generation of oxygen species induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and eotaxin (in the presence of IL-5) with -logIC(50) values of 3.61+/-0.03 and 3.36+/-0.09, respectively.	Oxygen	66-72	formyl peptide receptor 1	Homo sapiens	139-143
17456219-6	2007	RESULTS: NAC (0.1-1 mm) inhibited the extracellular generation of oxygen species induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and eotaxin (in the presence of IL-5) with -logIC(50) values of 3.61+/-0.03 and 3.36+/-0.09, respectively.	Oxygen	66-72	C-C motif chemokine ligand 11	Homo sapiens	149-156
17552288-6	2007	Multiple logistic regression analysis showed that insulin resistance as evaluated by fasting insulin, sigma insulin during OGTT, HOMA-IR, insulin sensitivity index, the levels of uric acid, fasting glucose, systolic blood pressure and maximal oxygen uptake were independently associated with ST segment depression.	Oxygen	243-249	insulin	Homo sapiens	50-57
17522445-2	2007	NO is synthesized from L-arginine and oxygen by nitric oxide synthase: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS).	Oxygen	38-44	nitric oxide synthase 2	Homo sapiens	123-127
17475478-3	2007	We screened the transcript levels of over 8000 genes in the estrogen receptor (ERalpha) positive T-47D human breast cancer cell lines maintained at 21% O2 or 1% O2 with or without E2 co-treatment.	Oxygen	152-154	estrogen receptor 1	Homo sapiens	60-77
17475478-3	2007	We screened the transcript levels of over 8000 genes in the estrogen receptor (ERalpha) positive T-47D human breast cancer cell lines maintained at 21% O2 or 1% O2 with or without E2 co-treatment.	Oxygen	152-154	estrogen receptor 1	Homo sapiens	79-86
17475478-3	2007	We screened the transcript levels of over 8000 genes in the estrogen receptor (ERalpha) positive T-47D human breast cancer cell lines maintained at 21% O2 or 1% O2 with or without E2 co-treatment.	Oxygen	161-163	estrogen receptor 1	Homo sapiens	60-77
17481888-7	2007	Moreover, we have shown that hypoxia (5% of oxygen) enhanced GR transactivation in both glial cells.	Oxygen	44-50	nuclear receptor subfamily 3 group C member 1	Homo sapiens	61-63
17381162-12	2007	These interactions of superoxide and myeloperoxidase will have a major influence on the way neutrophils use oxygen to kill bacteria.	Oxygen	108-114	myeloperoxidase	Homo sapiens	37-52
17325032-6	2007	These effects were mediated via three amino acid residues in the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
17444949-2	2007	In the present review, we summarize the current knowledge about the role of nitric oxide and reactive nitrogen species (RNS) derived from it in hypoxic signal transduction and particularly in accumulation/de-accumulation of hypoxia inducible factor 1 alpha (HIF-1alpha) protein, which is critical not only for cellular adaptation to low oxygen availability but also for generation of inflammatory and innate immune responses.	Oxygen	337-343	hypoxia inducible factor 1 subunit alpha	Homo sapiens	224-256
17444949-2	2007	In the present review, we summarize the current knowledge about the role of nitric oxide and reactive nitrogen species (RNS) derived from it in hypoxic signal transduction and particularly in accumulation/de-accumulation of hypoxia inducible factor 1 alpha (HIF-1alpha) protein, which is critical not only for cellular adaptation to low oxygen availability but also for generation of inflammatory and innate immune responses.	Oxygen	337-343	hypoxia inducible factor 1 subunit alpha	Homo sapiens	258-268
17342175-2	2007	Catalase is a highly conserved heme-containing protein that reduces hydrogen peroxide to water and oxygen and is an important factor decreasing cellular injury owing to oxidative stress.	Oxygen	99-105	catalase	Mus musculus	0-8
17390074-5	2007	Both hypoxia and reoxygenation induced statistically significant changes in uPA, PAI-1 and uPAR mRNA and protein levels in the various cell lines investigated, showing that oxygen tension is a strong modulator of the plasminogen activation system in vitro.	Oxygen	19-25	plasminogen activator, urokinase	Homo sapiens	76-79
17406354-3	2007	Here, we show that the transient transfection of the proline allele in p53 null cancer cells exposed to low oxygen tension or to the hypoxia-mimetic drug Desferoxamine induces a higher amount of cell death than the arginine allele.	Oxygen	108-114	tumor protein p53	Homo sapiens	71-74
17009333-2	2007	Hypoxia-inducible-factor-1alpha (HIF-1alpha) is a transcription factor that responds to low-oxygen environments by upregulating genes for cell survival and metabolism.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
17408620-7	2007	Application of 7beta-HC to ABCG1 expressing cells induced hyperpolarization of mitochondrial membrane potential and production of reactive oxygen species, indicating energy consumption by the ATP-binding cassette transporter when it is activated by its correct substrate.	Oxygen	139-145	ATP binding cassette subfamily G member 1	Homo sapiens	27-32
17408620-7	2007	Application of 7beta-HC to ABCG1 expressing cells induced hyperpolarization of mitochondrial membrane potential and production of reactive oxygen species, indicating energy consumption by the ATP-binding cassette transporter when it is activated by its correct substrate.	Oxygen	139-145	ATP binding cassette subfamily A member 4	Homo sapiens	192-224
17009333-2	2007	Hypoxia-inducible-factor-1alpha (HIF-1alpha) is a transcription factor that responds to low-oxygen environments by upregulating genes for cell survival and metabolism.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
17438103-2	2007	These are thought to be instigated by vascular endothelial growth factor, which, in turn, is regulated by cellular oxygen tension.	Oxygen	115-121	vascular endothelial growth factor A	Homo sapiens	38-72
17434127-2	2007	Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1alpha.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
17382205-1	2007	Molecular oxygen is involved in hydroxylation and subsequent degradation of HIF-1alpha, a subunit of HIF-1 transcription factor; therefore oxygen shortage (hypoxia) stabilizes this protein.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
17382205-1	2007	Molecular oxygen is involved in hydroxylation and subsequent degradation of HIF-1alpha, a subunit of HIF-1 transcription factor; therefore oxygen shortage (hypoxia) stabilizes this protein.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-81
17382205-1	2007	Molecular oxygen is involved in hydroxylation and subsequent degradation of HIF-1alpha, a subunit of HIF-1 transcription factor; therefore oxygen shortage (hypoxia) stabilizes this protein.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
17382205-1	2007	Molecular oxygen is involved in hydroxylation and subsequent degradation of HIF-1alpha, a subunit of HIF-1 transcription factor; therefore oxygen shortage (hypoxia) stabilizes this protein.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-81
17382205-2	2007	However, HIF-1alpha can also be stabilized by transition metal ions in the presence of oxygen, suggesting that a different mechanism is involved in metal-induced hypoxic stress.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
17434127-2	2007	Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1alpha.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
17434127-2	2007	Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1alpha.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
17434127-5	2007	As a result, the HIF-1alpha protein is S-nitrosylated at Cys533 (through "biotin switch" assay) in the oxygen-dependent degradation domain, which prevents its destruction.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
17434127-6	2007	Importantly, this mechanism appears to be independent of the prolylhydroxylase-based pathway that is involved in oxygen-dependent regulation of HIF-1alpha.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
17418782-1	2007	The hypoxia-inducible factor HIF-1 is known to promote anaerobic respiration during low oxygen conditions (hypoxia).	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
17428968-5	2007	Under hypoxic conditions (2.5 and 1% O2 exposure for 24 h), glutamate uptake was significantly reduced, and pharmacological separation of uptake transporter subtypes suggested that the EAAT2 subtype was preferentially reduced relative to the EAAT1.	Oxygen	37-39	solute carrier family 1 member 2	Homo sapiens	185-190
17355126-0	2007	Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1.	Oxygen	10-16	prostaglandin-endoperoxide synthase 1	Homo sapiens	60-76
17404504-6	2007	There is mounting evidence that Hif-1alpha, the oxygen sensitive subunit of HIF-1, provides protection against cell death and stimulates tumor growth by upregulating genes that are involved in cellular energy metabolism.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
17218454-4	2007	Based on the DMb, the equipoise diffusion PO2, the PO2 in which Mb-facilitated and free O2 diffusion contribute equally to the O2 flux, varies from 2.72 to 0.15 in myocardium and from 7.27 to 4.24 mmHg in skeletal muscle.	Oxygen	43-45	RT1 class II, locus DMb	Rattus norvegicus	13-16
17164436-3	2007	In wild-type (WT) mice, IL-1beta injection (5 microg/kg ip) increased body temperature (+1.82 degrees C at 20 min), decreased physical activity (-37% at 1 h), and produced a slight and insignificant rise (+15% at 1 h) in oxygen consumption (Vo(2)).	Oxygen	221-227	interleukin 1 beta	Mus musculus	24-32
17353002-1	2007	Aldehyde oxidase, a molybdoflavoenzyme that plays an important role in aldehyde biotransformation, requires oxygen as substrate and produces reduced oxygen species.	Oxygen	108-114	aldehyde oxidase 1	Homo sapiens	0-16
17353002-1	2007	Aldehyde oxidase, a molybdoflavoenzyme that plays an important role in aldehyde biotransformation, requires oxygen as substrate and produces reduced oxygen species.	Oxygen	149-155	aldehyde oxidase 1	Homo sapiens	0-16
17353002-7	2007	Electrochemical measurements of oxygen consumption and hydrogen peroxide formation yielded values of 650 and 355 nmol min(-1) mg(-1).	Oxygen	32-38	CD59 molecule (CD59 blood group)	Homo sapiens	118-124
17404504-6	2007	There is mounting evidence that Hif-1alpha, the oxygen sensitive subunit of HIF-1, provides protection against cell death and stimulates tumor growth by upregulating genes that are involved in cellular energy metabolism.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-81
17349933-4	2007	Overexpression of Bcl-2 significantly protected cells from oxygen-induced apoptosis, as shown by measurement of lactate dehydrogenase release, quantification of apoptotic nuclei, and detection of Annexin-V-positive cells.	Oxygen	59-65	B cell leukemia/lymphoma 2	Mus musculus	18-23
17300770-13	2007	In addition, the decrease of mRNA and protein levels in IGF-I/IGF-IR of VSD patients show related to the saturation of oxygen in the right atrium and the ratio of systolic right ventricular pressure to left ventricular pressure.	Oxygen	119-125	insulin like growth factor 1	Homo sapiens	56-61
17215485-6	2007	Moreover, we show that frh-1-inhibiting RNAi impairs oxygen consumption and that respiratory rate is positively correlated with life span in this multicellular eukaryote (r=0.8566), suggesting that >73% of life span variance in C. elegans is explained by changes in respiratory rate.	Oxygen	53-59	Frataxin, mitochondrial	Caenorhabditis elegans	23-28
17430107-0	2007	Substrate and cofactor requirements of indoleamine 2,3-dioxygenase in interferon-gamma-treated cells: utilization of oxygen rather than superoxide.	Oxygen	57-63	interferon gamma	Homo sapiens	70-86
17349933-8	2007	In addition, Bcl-2-overexpressing cells showed significantly higher intracellular amounts of glutathione after 72 h of oxygen exposure.	Oxygen	119-125	B cell leukemia/lymphoma 2	Mus musculus	13-18
17292965-1	2007	It is well known that the wild type Cu,Zn superoxide dismutase (holo SOD) catalyzes the conversion of superoxide anion to peroxide hydrogen and dioxygen.	Oxygen	144-152	superoxide dismutase 1	Homo sapiens	36-62
17189520-2	2007	Hypoxia-inducible factor (HIF)-1 plays an important role in mediating oxygen-regulated events.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
17292965-1	2007	It is well known that the wild type Cu,Zn superoxide dismutase (holo SOD) catalyzes the conversion of superoxide anion to peroxide hydrogen and dioxygen.	Oxygen	144-152	superoxide dismutase 1	Homo sapiens	69-72
17303160-6	2007	The major Drosophila hemoglobin binds oxygen with high affinity.	Oxygen	38-44	globin 1	Drosophila melanogaster	21-31
17303160-7	2007	This hemoglobin type possibly functions as a buffer system for oxygen supply at low partial pressures and/or for the protection from an excess of oxygen.	Oxygen	63-69	globin 1	Drosophila melanogaster	5-15
17303160-7	2007	This hemoglobin type possibly functions as a buffer system for oxygen supply at low partial pressures and/or for the protection from an excess of oxygen.	Oxygen	146-152	globin 1	Drosophila melanogaster	5-15
17311330-5	2007	TIMP-1 amounts were also negatively correlated with O2 saturation, and positively correlated with IL-6, MIP-1alpha, and G-CSF amounts following RSV infection.	Oxygen	52-54	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-6
17311330-6	2007	IL-6, MIP-1alpha, and G-CSF were negatively correlated with O2 saturation during RSV infection.	Oxygen	60-62	interleukin 6	Homo sapiens	0-4
17342317-1	2007	Hypoxia-inducible factor-1 (HIF-1) plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumors.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16716637-4	2007	A fully computer-controlled gas testing rig has been constructed to automate the varying of oxygen levels.	Oxygen	92-98	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	40-43
16698079-7	2007	We conclude that (1) the DNA and protein sequence for chymase in placental trophoblast cells are the same as those reported in the human heart; (2) CLP/chymase expression is upregulated in TCs during PE; and (3) lowered oxygen condition promotes CLP release by placental TCs.	Oxygen	220-226	chymase 1	Homo sapiens	54-61
16698079-7	2007	We conclude that (1) the DNA and protein sequence for chymase in placental trophoblast cells are the same as those reported in the human heart; (2) CLP/chymase expression is upregulated in TCs during PE; and (3) lowered oxygen condition promotes CLP release by placental TCs.	Oxygen	220-226	chymase 1	Homo sapiens	152-159
17342317-1	2007	Hypoxia-inducible factor-1 (HIF-1) plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumors.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17335280-1	2007	The direct oxygen sensor protein from Escherichia coli (Ec DOS) is a heme-based signal transducer protein responsible for phosphodiesterase (PDE) activity.	Oxygen	11-17	phosphodiesterase	Escherichia coli	122-139
17335280-1	2007	The direct oxygen sensor protein from Escherichia coli (Ec DOS) is a heme-based signal transducer protein responsible for phosphodiesterase (PDE) activity.	Oxygen	11-17	phosphodiesterase	Escherichia coli	141-144
17361105-2	2007	Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O2 concentration.	Oxygen	85-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17335280-2	2007	Binding of either O2 or CO molecule to a reduced heme enhances the PDE activity toward 3",5"-cyclic diguanylic acid.	Oxygen	18-20	phosphodiesterase	Escherichia coli	67-70
17258463-3	2007	Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency.	Oxygen	34-40	AKT serine/threonine kinase 1	Homo sapiens	172-175
17237236-3	2007	The reactivity of these thiol groups was very sensitive to oxidation by naphthoquinone, H2O2, NO, or O2, all known modulators of the RyR1 channel complex.	Oxygen	90-92	ryanodine receptor 1	Homo sapiens	133-137
17174941-7	2007	Treatment of SOD and catalase also reduced the intracellular H2O2 and loss of mitochondrial transmembrane potential (DeltaPsi(m)) without reducing O2- level and apoptosis in antimycin A-treated As4.1 cells.	Oxygen	63-65	catalase	Mus musculus	13-29
17361105-2	2007	Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O2 concentration.	Oxygen	85-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17158647-11	2007	Previously, we have reported that the oxygen-sensitive induction of p21/Cip1/Waf1/Sdi1 in cardiac fibroblasts in the peri-infarct zone plays a vital role in myocardial remodeling.	Oxygen	38-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-71
17410782-12	2007	In contrast to samples prepared in air, XAS experiments with samples prepared in the absence of oxygen revealed solely the presence of Co(II).	Oxygen	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
17179152-10	2007	In conclusion, our study elucidates a mechanism by which insulin and IGF-1 signaling can be matched to the oxygen level that is available to support growth and energy metabolism.	Oxygen	107-113	insulin like growth factor 1	Homo sapiens	69-74
17158647-11	2007	Previously, we have reported that the oxygen-sensitive induction of p21/Cip1/Waf1/Sdi1 in cardiac fibroblasts in the peri-infarct zone plays a vital role in myocardial remodeling.	Oxygen	38-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-76
17158647-11	2007	Previously, we have reported that the oxygen-sensitive induction of p21/Cip1/Waf1/Sdi1 in cardiac fibroblasts in the peri-infarct zone plays a vital role in myocardial remodeling.	Oxygen	38-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-81
17158647-11	2007	Previously, we have reported that the oxygen-sensitive induction of p21/Cip1/Waf1/Sdi1 in cardiac fibroblasts in the peri-infarct zone plays a vital role in myocardial remodeling.	Oxygen	38-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	82-86
17334528-11	2007	The opposite effect of iNOS blockade by AG in these models could be explained by restriction of oxygen for immune cells or an efficient action of NO in anaerobic localized infections.	Oxygen	96-102	nitric oxide synthase 2, inducible	Mus musculus	23-27
17126898-1	2007	Hb (hemoglobin)-loaded particles (HbP) encapsulated by a biodegradable polymer used as oxygen carrier were prepared.	Oxygen	87-93	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	34-37
17210255-7	2007	The loss of one H bond by the NH-O exchange might be partially compensated by, for example, the weak interaction of one furanyl oxygen with FLT3 Cys-828.	Oxygen	128-134	fms related receptor tyrosine kinase 3	Homo sapiens	140-144
17348829-3	2007	VEGF increases vascular permeability, which might facilitate tumor dissemination via the circulation causing a greater delivery of oxygen and nutrients; it recruits circulating endothelial precursor cells, and acts as a survival factor for immature tumor blood vessels.	Oxygen	131-137	vascular endothelial growth factor A	Homo sapiens	0-4
16920014-7	2007	OLE1 is regulated through Spt23p and Mga2p by multiple systems that control its transcription and mRNA stability in response to diverse stimuli that include nutrient fatty acids, carbon source, metal ions and the availability of oxygen.	Oxygen	229-235	Spt23p	Saccharomyces cerevisiae S288C	26-32
17259593-0	2007	A luminescent oxygen channeling immunoassay for the determination of insulin in human plasma.	Oxygen	14-20	insulin	Homo sapiens	69-76
17253966-5	2007	During the last 15 yr, major progress has been made in identifying the molecules controlling Epo gene expression, primarily the hypoxia-inducible transcription factors (HIF) that are regulated by specific O2 and oxoglutarate requiring Fe2+-containing dioxygenases.	Oxygen	205-207	erythropoietin	Homo sapiens	93-96
17197389-1	2007	Hypoxia-inducible factor-1 (HIF-1) coordinates the cellular response to a lack of oxygen by controlling the expression of hypoxia-inducible genes that ensure an adequate energy supply.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17197389-1	2007	Hypoxia-inducible factor-1 (HIF-1) coordinates the cellular response to a lack of oxygen by controlling the expression of hypoxia-inducible genes that ensure an adequate energy supply.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
17197389-2	2007	Assembly of the HIF-1 complex by its oxygen-regulated subunit HIF-1alpha and its constitutive beta subunit also known as ARNT is the key event of the cellular genetic response to hypoxia.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
17197389-2	2007	Assembly of the HIF-1 complex by its oxygen-regulated subunit HIF-1alpha and its constitutive beta subunit also known as ARNT is the key event of the cellular genetic response to hypoxia.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
17366925-7	2007	Oxygen 6 l x min(-1) was adminisitered to prevent both desaturation of patient and fogging of blade during intubation procedure.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	13-19
17306562-4	2007	The permeability of AQP1 to two types of gas molecules, O2 and CO2, was investigated using two complementary methods, namely, explicit gas diffusion simulation and implicit ligand sampling.	Oxygen	56-58	aquaporin 1 (Colton blood group)	Homo sapiens	20-24
17414341-5	2007	RESULTS: After hemodynamic decompensation, AVP resulted in a significantly higher increase of CPP (mean +/- SD; 47 +/- 19 versus 28 +/- 9 mm Hg; p &lt; 0.01) and cerebral venous partial pressure of oxygen (66 +/- 8 versus 49 +/- 9 mm Hg; p &lt; 0.05) compared with NE after 10 minutes of therapy.	Oxygen	198-204	vasopressin	Sus scrofa	43-46
17208929-0	2007	The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes.	Oxygen	15-21	interleukin 6	Homo sapiens	79-92
17208929-4	2007	The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology.	Oxygen	400-406	interleukin 1 beta	Homo sapiens	83-91
17208929-4	2007	The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology.	Oxygen	461-467	interleukin 1 beta	Homo sapiens	83-91
17564285-7	2007	Additional oxygen, autologous and homologous transfusion and erythropoietin, mainly the synthetic type, have been administered with the aim of increasing the amount of oxygen being delivered to the tissues.	Oxygen	168-174	erythropoietin	Homo sapiens	61-75
16517059-2	2007	Specifically, NAD(P)H:quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase Ya subunit (Gst ya) are key enzymes involved in cellular defense against reactive forms of oxygen and the inhibition of carcinogenesis.	Oxygen	175-181	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-46
17273746-5	2007	In addition, immunoprecipitation and in vitro binding assays revealed that HDAC1 and 3 directly bind to the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	108-114	histone deacetylase 1	Homo sapiens	75-86
17273746-5	2007	In addition, immunoprecipitation and in vitro binding assays revealed that HDAC1 and 3 directly bind to the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
16964624-6	2007	Specifically, we applied random mutagenesis and a multi-stage flow cytometry screen to isolate mutants of the oxygen-responsive Saccharomyces cerevisiae DAN1 promoter.	Oxygen	110-116	Dan1p	Saccharomyces cerevisiae S288C	153-157
16517059-2	2007	Specifically, NAD(P)H:quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase Ya subunit (Gst ya) are key enzymes involved in cellular defense against reactive forms of oxygen and the inhibition of carcinogenesis.	Oxygen	175-181	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
17095038-3	2007	Oxidants (i.e., dissolved oxygen (DO) and chlorine) present in the water, however, may decrease the DBP degradation rate by competing for reactive sites and rapidly aging or corroding the iron surface.	Oxygen	26-32	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
17969555-15	2007	Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-.	Oxygen	192-198	CD33 molecule	Homo sapiens	11-14
17969555-15	2007	Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-.	Oxygen	223-225	CD33 molecule	Homo sapiens	11-14
17387264-5	2007	This alteration in oxygen metabolism would drive tumor invasion and metastasis via glycolysis-mediated extracellular acidification, excessive production of hydrogen peroxide (H(2)O(2)) and hypoxia-inducible factor 1 (HIF-1) activation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	189-215
17387264-5	2007	This alteration in oxygen metabolism would drive tumor invasion and metastasis via glycolysis-mediated extracellular acidification, excessive production of hydrogen peroxide (H(2)O(2)) and hypoxia-inducible factor 1 (HIF-1) activation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-222
16977326-6	2007	In low-oxygen conditions, the cells exhibited increased colony-forming ability, consistent with a lower proportion of differentiated cells, and increased expression of vascular endothelial growth factor and cyclooxygenase-2.	Oxygen	7-13	vascular endothelial growth factor A	Homo sapiens	168-202
17289868-6	2007	Ironically, recent investigations suggest that oxygen depletion stimulates mitochondria to elaborate increased ROS, with subsequent activation of signaling pathways, such as hypoxia inducible factor 1alpha, that promote cancer cell survival and tumor growth.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	174-205
17071723-7	2007	Exposure of primary lung fibroblasts to 85% O(2) significantly enhanced the TGF-beta-stimulated production of the alpha(1) subunit of type I collagen (Ialpha(1)), tissue inhibitor of metalloproteinase-1, tropoelastin, and tenascin-C.	Oxygen	44-48	tissue inhibitor of metalloproteinase 1	Mus musculus	163-202
16741710-12	2007	CONCLUSION: An IP injection of 17-AAG is able to reduce angioproliferative retinopathy in a mouse model for oxygen-induced retinopathy.	Oxygen	108-114	N-methylpurine-DNA glycosylase	Mus musculus	34-37
17013614-1	2007	A contributing factor to the pathology of Alzheimer"s disease is the generation of reactive oxygen species, most probably a consequence of the beta-amyloid (Abeta) peptide coordinating copper ions.	Oxygen	92-98	amyloid beta precursor protein	Homo sapiens	157-162
17013614-4	2007	The Abeta-Cu(II) complex has been shown to catalytically generate H(2)O(2) from reducing agents and O(2).	Oxygen	70-74	amyloid beta precursor protein	Homo sapiens	4-9
16977326-6	2007	In low-oxygen conditions, the cells exhibited increased colony-forming ability, consistent with a lower proportion of differentiated cells, and increased expression of vascular endothelial growth factor and cyclooxygenase-2.	Oxygen	7-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	207-223
16924414-3	2007	In this study, we determined that mitochondrial uncouplers, rottlerin and FCCP, significantly decreased hypoxic as well as normoxic HIF-1 transcriptional activity which was in part mediated by down-regulation of the oxygen labile HIF-1alpha and HIF-2alpha protein levels in PC-3 and DU-145 prostate cancer cells.	Oxygen	216-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-137
17101781-1	2007	Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-alpha) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in oxygen (O(2))-replete cells.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-67
17101781-1	2007	Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-alpha) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in oxygen (O(2))-replete cells.	Oxygen	197-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-67
16924414-3	2007	In this study, we determined that mitochondrial uncouplers, rottlerin and FCCP, significantly decreased hypoxic as well as normoxic HIF-1 transcriptional activity which was in part mediated by down-regulation of the oxygen labile HIF-1alpha and HIF-2alpha protein levels in PC-3 and DU-145 prostate cancer cells.	Oxygen	216-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	230-240
17321223-3	2007	We have shown that a mutation in a subunit, cytochrome b large subunit (SDHC), of complex II, also results in increasing O2- production and therefore lead to apoptosis and precocious aging in Caenorhabditis elegans.	Oxygen	121-123	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	72-76
17276741-3	2007	A concept of mitochondrial radical metabolism is suggested based on the two electron-leak pathways mediated by cytochrome c are metabolic routes of O2-*.	Oxygen	148-150	cytochrome c, somatic	Homo sapiens	111-123
17276741-7	2007	The models of respiratory chain operating with two cytochrome c-mediated electron-leak pathways and a radical metabolism of mitochondria accompanied with energy metabolism are helpful to comprehend the pathological problems caused by oxygen toxicity.	Oxygen	234-240	cytochrome c, somatic	Homo sapiens	51-63
17276741-0	2007	Detoxifying function of cytochrome c against oxygen toxicity.	Oxygen	45-51	cytochrome c, somatic	Homo sapiens	24-36
17276741-1	2007	The detoxifying function of cytochrome c to scavenge O2-* and H2O2 in mitochondria is confirmed experimentally.	Oxygen	53-55	cytochrome c, somatic	Homo sapiens	28-40
17301694-5	2007	COX-1 metabolic activity was evaluated in vitro using an oxygen consumption assay under basal conditions and in the presence of indomethacin.	Oxygen	57-63	prostaglandin-endoperoxide synthase 1	Homo sapiens	0-5
17200441-7	2007	HHcy significantly decreased bradykinin- or carbachol-induced reduction of myocardial oxygen consumption in vitro, and this effect was completely restored by coincubation with ascorbic acid, Tempol, or apocynin.	Oxygen	86-92	kininogen 1	Canis lupus familiaris	29-39
17287564-4	2007	Mean-while, water loss results in increased activities of reactive-oxygen-scavenging enzymes (SOD, CAT, APX and GR).	Oxygen	67-73	catalase	Homo sapiens	99-102
17645840-2	2007	METHODS: The mRNA and protein levels of HIF-1alpha, mdr-1 and p-gp were studied by immunocytochemistry, semiquantitative reverse transcription-ploymerase chain reaction (RT-PCR) and Western blot analysis in human ovarian cancer cells (A2780) in 5% CO2 + 1% O2 hypoxic culture and 21% O2 normoxic culture, respectively.	Oxygen	249-251	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
17645840-2	2007	METHODS: The mRNA and protein levels of HIF-1alpha, mdr-1 and p-gp were studied by immunocytochemistry, semiquantitative reverse transcription-ploymerase chain reaction (RT-PCR) and Western blot analysis in human ovarian cancer cells (A2780) in 5% CO2 + 1% O2 hypoxic culture and 21% O2 normoxic culture, respectively.	Oxygen	257-259	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
17645840-8	2007	The HIF-1alpha expression at mRNA level was oxygen gradient-independent, while HIF-1alpha expression at protein level was oxygen gradient-dependent.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
17645840-8	2007	The HIF-1alpha expression at mRNA level was oxygen gradient-independent, while HIF-1alpha expression at protein level was oxygen gradient-dependent.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
17060326-0	2007	Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-67
17060326-1	2007	The transcription factor complex hypoxia-inducible factor 1 (HIF-1) plays a crucial role in cellular adaptation to low oxygen availability.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-59
17060326-1	2007	The transcription factor complex hypoxia-inducible factor 1 (HIF-1) plays a crucial role in cellular adaptation to low oxygen availability.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
17196530-2	2007	Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique mechanism involving an "NO-reactive oxygen sensor motif" whose determinants include C744 and C798 of the NR1 subunit.	Oxygen	125-131	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	194-197
17233898-7	2007	There was also a "memory" of HIF-1alpha and HIF target gene induction when oxygen levels were normalized for one week, and this "memory" could be interrupted by adding a small molecule HIF inhibitor to the last week of normalized oxygen.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
17233898-7	2007	There was also a "memory" of HIF-1alpha and HIF target gene induction when oxygen levels were normalized for one week, and this "memory" could be interrupted by adding a small molecule HIF inhibitor to the last week of normalized oxygen.	Oxygen	230-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
17233898-8	2007	Finally, levels of ubiquitylated HIF-1alpha were reduced in response to chronic mild decreased oxygen and were not full restored after oxygen normalization.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
17189822-2	2007	Cells exposed to low oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as an adaptive response.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-105
17189822-2	2007	Cells exposed to low oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as an adaptive response.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-112
17213624-6	2007	This sensor could determine DMSO in an unpurged aqueous solution with glucose oxidase (GOD) and catalase (CAT) for oxygen removal.	Oxygen	115-121	catalase	Homo sapiens	96-104
17085088-8	2007	There was however a clear correlation between the surface nickel and oxygen concentration and the amount of albumin adsorbed.	Oxygen	69-75	albumin	Homo sapiens	108-115
17085088-9	2007	Samples with higher levels of nickel and less oxygen in the surface oxide layer of the wires showed increased albumin adsorption, which could lead to improved biocompatibility.	Oxygen	46-52	albumin	Homo sapiens	110-117
18269190-7	2007	Recent studies using BOLD-MRI showed an immediate decrease of oxygen tension in the kidney after angiotensin II infusion.	Oxygen	62-68	angiotensinogen	Rattus norvegicus	97-111
17051422-1	2007	Mammalian hexokinase (HXK) is found at the outer mitochondrial membrane, exposed to mitochondrial oxygen- and nitrogen-radicals.	Oxygen	98-104	hexokinase 1	Homo sapiens	10-20
17051422-1	2007	Mammalian hexokinase (HXK) is found at the outer mitochondrial membrane, exposed to mitochondrial oxygen- and nitrogen-radicals.	Oxygen	98-104	hexokinase 1	Homo sapiens	22-25
17332988-5	2007	Excessive oxygen contributes to ROP through regulation of vascular endothelial growth factor (VEGF).	Oxygen	10-16	vascular endothelial growth factor A	Homo sapiens	58-92
17332988-5	2007	Excessive oxygen contributes to ROP through regulation of vascular endothelial growth factor (VEGF).	Oxygen	10-16	vascular endothelial growth factor A	Homo sapiens	94-98
17332988-6	2007	Suppression of VEGF by oxygen in phase I of ROP inhibits normal vessel growth, whereas elevated levels of VEGF induced by hypoxia in phase II of ROP precipitate pathological vessel proliferation.	Oxygen	23-29	vascular endothelial growth factor A	Homo sapiens	15-19
17213624-6	2007	This sensor could determine DMSO in an unpurged aqueous solution with glucose oxidase (GOD) and catalase (CAT) for oxygen removal.	Oxygen	115-121	catalase	Homo sapiens	106-109
17406058-9	2007	Under low oxygen tension, cells increase the transcription of specific genes via stabilization of the transcription factor hypoxia-inducible factor (HIF)-1.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-155
17174724-6	2007	There was also a negative relationship between oxygen uptake during cycling and presence of the IGF-I189 independent of AFADM (p = 0.010).	Oxygen	47-53	insulin like growth factor 1	Homo sapiens	96-101
17640365-0	2007	Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-60
16956324-1	2007	A central means by which mammalian cells respond to low oxygen tension is through the activation of the transcription factor HIF-1 (hypoxia-inducible factor-1).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-130
16956324-1	2007	A central means by which mammalian cells respond to low oxygen tension is through the activation of the transcription factor HIF-1 (hypoxia-inducible factor-1).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-158
16754651-6	2007	Carriers of the IFNgamma(+874)T allele required mechanical ventilation and oxygen supplementation for time periods 41% and 35%, respectively, shorter than those required by those not carrying the IFNgamma(+874)T allele.	Oxygen	75-81	interferon gamma	Homo sapiens	16-24
17237644-4	2007	Recent studies have documented increased O2 in endothelial cells exposed to H2O2 via uncoupled nitric oxide synthase (NOS) and NADPH oxidase under static conditions.	Oxygen	41-43	nitric oxide synthase 2	Homo sapiens	95-116
16952279-2	2007	An oxygen consumption assay was developed and used to study the relationship between HIF hydroxylase activity and oxygen concentration for recombinant forms of two human HIF hydroxylases, PHD2 (prolyl hydroxylase domain-containing protein 2) and FIH (factor inhibiting HIF), and compared with two other 2OG-dependent dioxygenases.	Oxygen	3-9	egl-9 family hypoxia inducible factor 1	Homo sapiens	188-192
16952279-2	2007	An oxygen consumption assay was developed and used to study the relationship between HIF hydroxylase activity and oxygen concentration for recombinant forms of two human HIF hydroxylases, PHD2 (prolyl hydroxylase domain-containing protein 2) and FIH (factor inhibiting HIF), and compared with two other 2OG-dependent dioxygenases.	Oxygen	3-9	egl-9 family hypoxia inducible factor 1	Homo sapiens	194-240
16952279-2	2007	An oxygen consumption assay was developed and used to study the relationship between HIF hydroxylase activity and oxygen concentration for recombinant forms of two human HIF hydroxylases, PHD2 (prolyl hydroxylase domain-containing protein 2) and FIH (factor inhibiting HIF), and compared with two other 2OG-dependent dioxygenases.	Oxygen	114-120	egl-9 family hypoxia inducible factor 1	Homo sapiens	188-192
16952279-2	2007	An oxygen consumption assay was developed and used to study the relationship between HIF hydroxylase activity and oxygen concentration for recombinant forms of two human HIF hydroxylases, PHD2 (prolyl hydroxylase domain-containing protein 2) and FIH (factor inhibiting HIF), and compared with two other 2OG-dependent dioxygenases.	Oxygen	114-120	egl-9 family hypoxia inducible factor 1	Homo sapiens	194-240
16952279-3	2007	Although there are caveats on the absolute values, the apparent K(m) (oxygen) values for PHD2 and FIH were within the range observed for other 2OG oxygenases.	Oxygen	70-76	egl-9 family hypoxia inducible factor 1	Homo sapiens	89-93
16952279-5	2007	The analyses also suggest that human PHD2 is selective for fragments of the C-terminal over the N-terminal oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	107-113	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
16952279-5	2007	The analyses also suggest that human PHD2 is selective for fragments of the C-terminal over the N-terminal oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
16952394-8	2007	Compared with PLGA(70/30), the apatite layer formed on oxygen plasma-treated PLGA(70/30) surface enhanced adhesion and proliferation of OCT-1 osteoblast-like cell, but had no significant effect on cell"s ALP activity at day 7.	Oxygen	55-61	solute carrier family 22 member 1	Homo sapiens	136-141
17215574-2	2007	This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress.	Oxygen	154-160	C-reactive protein	Homo sapiens	56-74
17215574-2	2007	This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress.	Oxygen	154-160	C-reactive protein	Homo sapiens	76-79
16996047-0	2007	Effects of hyperbaric oxygen therapy on circulating interleukin-8, nitric oxide, and insulin-like growth factors in patients with type 2 diabetes mellitus.	Oxygen	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
16996047-0	2007	Effects of hyperbaric oxygen therapy on circulating interleukin-8, nitric oxide, and insulin-like growth factors in patients with type 2 diabetes mellitus.	Oxygen	22-28	insulin	Homo sapiens	85-92
17022961-2	2007	Evidence from in vitro and structural analyses supports a critical role for Cited2 in down-regulating HIF-1-mediated transcription by competing for binding with oxygen-sensitive HIF-1alpha to transcriptional co-activators CBP/p300.	Oxygen	161-167	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	76-82
18177510-1	2007	Infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac index and systemic oxygen transport.	Oxygen	134-140	arginine vasopressin	Homo sapiens	18-29
18177510-1	2007	Infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac index and systemic oxygen transport.	Oxygen	134-140	arginine vasopressin	Homo sapiens	31-34
17402592-2	2007	Nebivolol increased the values of p50 (pO2 at 50% hemoglobin saturation with oxygen) under real pH and pCO2 (by 4.3 +/- 0.8 mm Hg at the lowest concentration (p &lt; 0.01).	Oxygen	77-83	nuclear factor kappa B subunit 1	Homo sapiens	34-37
17045587-9	2007	Thus, reduced oxygen levels lead to activation of the Dll4-Notch-Hey2 signaling cascade and subsequent repression of COUP-TFII in endothelial progenitor cells.	Oxygen	14-20	nuclear receptor subfamily 2 group F member 2	Homo sapiens	117-126
17117714-9	2007	Recently, two novel BMs, namely, P50, a measure of ex vivo/in vitro whole blood oxygen affinity and S(pO2), i.e., in vivo pulse oximetry, were used in the development of an allosteric synthetic hemoglobin modifier (SAM), efaproxiral, as PD endpoints; these BMs are based on the MOA of SAMs.	Oxygen	80-86	nuclear factor kappa B subunit 1	Homo sapiens	33-36
17139180-2	2007	A low oxygen tension induces hypoxia-inducible factor-1 (HIF-1alpha) which may play an important role as a transcription factor in maintaining the proliferative and undifferentiated phenotype in human trophoblasts.	Oxygen	6-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
17164174-6	2007	We demonstrate that hypoxia (0.5% O2) elicits macrophages to produce higher levels of O2*-, TGF-beta, and VEGF than normoxia.	Oxygen	34-36	transforming growth factor beta 1	Homo sapiens	92-100
17164174-6	2007	We demonstrate that hypoxia (0.5% O2) elicits macrophages to produce higher levels of O2*-, TGF-beta, and VEGF than normoxia.	Oxygen	34-36	vascular endothelial growth factor A	Homo sapiens	106-110
17185023-7	2007	Pre-incubation of amyloid-beta peptide-treated erythrocytes with a specific inhibitor of caspase 3, partially restores the oxygen-dependent modulation.	Oxygen	123-129	caspase 3	Homo sapiens	89-98
17101841-1	2007	Prolyl hydroxylase domain 2 protein (PHD2) signals the degradation of hypoxia-inducible factor (HIF)-1alpha by hydroxylating specific prolyl residues located within oxygen-dependent degradation domains.	Oxygen	165-171	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
17101841-1	2007	Prolyl hydroxylase domain 2 protein (PHD2) signals the degradation of hypoxia-inducible factor (HIF)-1alpha by hydroxylating specific prolyl residues located within oxygen-dependent degradation domains.	Oxygen	165-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-107
17197733-16	2007	CONCLUSIONS: The results of our study suggest higher oxygen-free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and catalase activity, support to the oxidative stress in osteoarthritis.	Oxygen	53-59	catalase	Homo sapiens	160-168
17135360-8	2007	A requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA (siRNA).	Oxygen	73-79	death associated protein 3	Homo sapiens	18-22
17185023-8	2007	This finding suggests that human erythrocytes following to exposure to amyloid-beta peptide show a complete loss of the oxygen-dependent metabolic modulation, which is partially restored by caspase 3 inhibitor-treatment.	Oxygen	120-126	caspase 3	Homo sapiens	190-199
17018578-7	2007	We demonstrate that inhibition of HO1 reflects an interaction of MGd with NADPH-cytochrome P450 reductase, the electron donor for HO1, that results in diversion of reducing equivalents from heme oxidation to oxygen reduction.	Oxygen	208-214	cytochrome p450 oxidoreductase	Homo sapiens	74-105
16962833-3	2007	When the effect of exposure of plasma to radical oxygen species on binding of thiols to albumin was determined by the present method, significant increases in the ratio of cysteine bound to albumin (Alb-Cys) to total cysteine were clearly demonstrated.	Oxygen	49-55	albumin	Homo sapiens	199-202
17198096-3	2007	In this study, we used Western blot analysis and propidium iodide stain to determine whether the activations of nPKCepsilon and ERKs were involved in oxygen-glucose deprivation (OGD)-induced neuroprotection via N-methyl-D-aspartate (NMDA) receptors.	Oxygen	150-156	mitogen-activated protein kinase 1	Mus musculus	128-132
17095558-1	2007	Erythropoietin (Epo) has been suggested to affect plasma volume, and would thereby possess a mechanism apart from erythropoiesis to increase arterial oxygen content.	Oxygen	150-156	erythropoietin	Homo sapiens	0-14
17095558-1	2007	Erythropoietin (Epo) has been suggested to affect plasma volume, and would thereby possess a mechanism apart from erythropoiesis to increase arterial oxygen content.	Oxygen	150-156	erythropoietin	Homo sapiens	16-19
17998050-1	2007	The hypoxia-inducible factor (HIF) is a heterodimeric basic helix-loop-helix (bHLH) transcription factor that controls the mammalian cellular transcriptional response to low oxygen tension by up-regulating genes including glycolytic enzymes and angiogenic factors, such as the vascular endothelial growth factor (VEGF).	Oxygen	174-180	vascular endothelial growth factor A	Homo sapiens	277-311
17998050-1	2007	The hypoxia-inducible factor (HIF) is a heterodimeric basic helix-loop-helix (bHLH) transcription factor that controls the mammalian cellular transcriptional response to low oxygen tension by up-regulating genes including glycolytic enzymes and angiogenic factors, such as the vascular endothelial growth factor (VEGF).	Oxygen	174-180	vascular endothelial growth factor A	Homo sapiens	313-317
17998052-3	2007	A hypoxia-responsive system homologous to mammalian hypoxia-inducible factor (HIF) has been described in the fruit fly, where Fatiga is a Drosophila oxygen-dependent HIF prolyl hydroxylase, and the basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins Sima and Tango are, respectively, the Drosophila homologues of mammalian HIF-alpha (alpha) and HIF-beta (beta).	Oxygen	149-155	HIF prolyl hydroxylase	Drosophila melanogaster	126-132
17998052-3	2007	A hypoxia-responsive system homologous to mammalian hypoxia-inducible factor (HIF) has been described in the fruit fly, where Fatiga is a Drosophila oxygen-dependent HIF prolyl hydroxylase, and the basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins Sima and Tango are, respectively, the Drosophila homologues of mammalian HIF-alpha (alpha) and HIF-beta (beta).	Oxygen	149-155	similar	Drosophila melanogaster	254-258
17998069-1	2007	Decreased oxygen availability evokes adaptive responses, which are primarily under the gene regulatory control of hypoxia-inducible factor 1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-140
17998069-1	2007	Decreased oxygen availability evokes adaptive responses, which are primarily under the gene regulatory control of hypoxia-inducible factor 1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-147
17998069-3	2007	The HIF-1 transcriptional system senses decreased oxygen availability and transmits this signal into pathophysiological responses, such as angiogenesis, erythropoiesis, vasomotor control, an altered energy metabolism, and/or cell survival decisions.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
17998070-4	2007	Recent work has uncovered mechanisms by which hypoxia modulates the activation of NF-kappaB in cells through decreased oxygen-dependent suppression of the key regulators of this pathway.	Oxygen	119-125	nuclear factor kappa B subunit 1	Homo sapiens	82-91
17182883-5	2007	In contrast, a low HIF-1alpha score correlates with primary nonfunction, likely reflecting loss of oxygen consumption for tubular transport.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
17164295-1	2007	Nitric oxide (NO), generated endogenously in NO-synthase-transfected cells, increases the reduction of mitochondrial cytochrome c oxidase (CcO) at O2 concentrations ([O2]) above those at which it inhibits cell respiration.	Oxygen	147-149	cytochrome c, somatic	Homo sapiens	117-129
17164295-1	2007	Nitric oxide (NO), generated endogenously in NO-synthase-transfected cells, increases the reduction of mitochondrial cytochrome c oxidase (CcO) at O2 concentrations ([O2]) above those at which it inhibits cell respiration.	Oxygen	167-169	cytochrome c, somatic	Homo sapiens	117-129
17209132-2	2007	Catalase is a major antioxidant enzyme that detoxifies hydrogen peroxide by converting it into water and oxygen, thereby preventing cellular injury by oxidative stress.	Oxygen	105-111	catalase	Homo sapiens	0-8
17493766-6	2007	A recently discovered "normobaric oxygen paradox" demonstrates that renal tissue can be stimulated to increase EPO production via a simple pattern of oxygen breathing at normal atmospheric pressures.	Oxygen	34-40	erythropoietin	Homo sapiens	111-114
17493766-6	2007	A recently discovered "normobaric oxygen paradox" demonstrates that renal tissue can be stimulated to increase EPO production via a simple pattern of oxygen breathing at normal atmospheric pressures.	Oxygen	150-156	erythropoietin	Homo sapiens	111-114
17365660-8	2007	Thus, the RRF pathway is sensitive to changes in oxygen tension and might be a sensitive mechanism for adjusting vascular diameter to retinal oxygen levels.	Oxygen	49-55	mitochondrial ribosome recycling factor	Rattus norvegicus	10-13
17365660-8	2007	Thus, the RRF pathway is sensitive to changes in oxygen tension and might be a sensitive mechanism for adjusting vascular diameter to retinal oxygen levels.	Oxygen	142-148	mitochondrial ribosome recycling factor	Rattus norvegicus	10-13
16998808-0	2007	The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-87
17070589-4	2007	The VHL protein is required for oxygen-dependent degradation of hypoxia-inducible factor 1alpha.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-95
18087198-0	2007	Inducible nitric oxide synthase mediates hypoxia-induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen-induced retinopathy.	Oxygen	154-160	nitric oxide synthase 2	Homo sapiens	0-31
18087198-0	2007	Inducible nitric oxide synthase mediates hypoxia-induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen-induced retinopathy.	Oxygen	154-160	vascular endothelial growth factor A	Homo sapiens	105-139
16998808-1	2007	BACKGROUND: The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1), consisting of a critically regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit, is a master regulator of genes involved in adaptation and survival under low-oxygen conditions.	Oxygen	272-278	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-56
16998808-1	2007	BACKGROUND: The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1), consisting of a critically regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit, is a master regulator of genes involved in adaptation and survival under low-oxygen conditions.	Oxygen	272-278	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-84
16998808-1	2007	BACKGROUND: The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1), consisting of a critically regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit, is a master regulator of genes involved in adaptation and survival under low-oxygen conditions.	Oxygen	272-278	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-135
16998808-1	2007	BACKGROUND: The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1), consisting of a critically regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit, is a master regulator of genes involved in adaptation and survival under low-oxygen conditions.	Oxygen	272-278	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-129
16998808-3	2007	METHODS: We studied 402 prostate cancer patients for the presence of the 1772C &gt; T (P582S) and 1790G &gt; A (A588T) mutations within the oxygen-dependent domain of HIF-1 alpha.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-178
17396564-1	2007	Phytogenous flavonoid-containing agents (PFCA) are able to initiate electron flow bypassing the NAD-dependent region of respiratory chain, which is related with the activity of DT-diaphorase catalyzing two-electron reduction of quinones to hydroquinones and hydrogen peroxide in the presence of NADH and oxygen.	Oxygen	304-310	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-190
17935120-0	2007	Oxygen exchange between (de)nitrification intermediates and H2O and its implications for source determination of NO3- and N2O: a review.	Oxygen	0-6	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
17049893-0	2007	Influence of hyperbaric oxygen on tumor necrosis factor-alpha and nitric oxide production in endotoxin-induced acute lung injury in rats.	Oxygen	24-30	tumor necrosis factor	Rattus norvegicus	34-61
17244751-2	2007	We examined the hypothesis that at physiological (35-50 mmHg) oxygen tensions, the production of TNFalpha stimulates the apoptosis of placental trophoblasts associated with infants that are intrauterine growth-restricted (IUGR).	Oxygen	62-68	tumor necrosis factor	Homo sapiens	97-105
17891653-10	2007	A significant correlation was found between arterial oxygen partial pressure and individual S100B concentration in the pulmonary and systemic bloodstream in the entire study group (R = -0.66 and R = 0.71, respectively; p &lt; 0.05, for both).	Oxygen	53-59	S100 calcium binding protein B	Homo sapiens	92-97
17396559-4	2007	The most significant of them is HIF-1alpha, transcription factor playing an important role in the regulation of oxygen homeostasis in the cell as well as in resistance of the heart and the brain to ischemic and reperfusion injury.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
17284428-9	2007	In addition, the expression of HIF-1alpha mRNA in the brain of Tibetan chicken embryos was similar to that of the low-altitude chickens when they were hatched under normal oxygen tensions.	Oxygen	172-178	hypoxia inducible factor 1 alpha subunit	Gallus gallus	31-41
17802835-0	2007	Interaction of oxygen concentration and retention of pollutants in vertical flow constructed wetlands for CSO treatment.	Oxygen	15-21	twist family bHLH transcription factor 1	Homo sapiens	106-109
17305120-2	2007	A commercial catalase, which is an enzyme to decompose hydrogen peroxide to water and oxygen, was entrapped in chitosan beads.	Oxygen	86-92	catalase	Homo sapiens	13-21
17181304-5	2006	In the 17beta-estradiol molecule, the oxygen atoms appear to be close to sp3 in shape, exhibiting two consistent, distinct lone pairs despite different chemical environments.	Oxygen	38-44	Sp3 transcription factor	Homo sapiens	73-76
17181240-6	2006	Although the electroactive Pt surface area is larger for commercial electrodes of similar loadings, Pt/MWCNT electrodes largely outperform the commercial electrode for the oxygen reduction reaction in GDE experiments using H2SO4 at pH 1.	Oxygen	172-178	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	201-204
17177465-3	2006	For the diester, ethyl p-nitrophenyl phosphate, the nonbridge 18O effect for the hydrolysis reactions catalyzed by Co(III) 1,5,9-triazacyclononane and Eu(III) were 1.0006 and 1.0016, respectively, indicative of a slightly associative transition state and little net change in bonding to the nonbridge oxygen.	Oxygen	301-307	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	118-121
17177465-3	2006	For the diester, ethyl p-nitrophenyl phosphate, the nonbridge 18O effect for the hydrolysis reactions catalyzed by Co(III) 1,5,9-triazacyclononane and Eu(III) were 1.0006 and 1.0016, respectively, indicative of a slightly associative transition state and little net change in bonding to the nonbridge oxygen.	Oxygen	301-307	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	154-157
17177468-4	2006	This is 80-fold smaller than kiso = 3.2 x 10-4 s-1 for the isomerization that exchanges oxygen-16 and oxygen-18 of 3-NO2C6H413CH(Me)OS(18O)2Tos during solvolysis and 10-fold smaller than the minimum value of k(rac) = 4.6 x 10-5 s-1 predicted if isomerization and racemization products form by partitioning of a common ion-pair intermediate of a stepwise reaction.	Oxygen	88-94	AKT serine/threonine kinase 1	Homo sapiens	210-213
17177468-4	2006	This is 80-fold smaller than kiso = 3.2 x 10-4 s-1 for the isomerization that exchanges oxygen-16 and oxygen-18 of 3-NO2C6H413CH(Me)OS(18O)2Tos during solvolysis and 10-fold smaller than the minimum value of k(rac) = 4.6 x 10-5 s-1 predicted if isomerization and racemization products form by partitioning of a common ion-pair intermediate of a stepwise reaction.	Oxygen	102-108	AKT serine/threonine kinase 1	Homo sapiens	210-213
16990406-12	2006	These findings are consistent with metabolic inertia, via delayed activation of PDH, in part limiting the adaptation of pulmonary .VO2 and muscle O2 consumption during the normal transition to exercise.	Oxygen	132-134	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	80-83
17040902-2	2006	Hsps are known to be regulated by heat shock factor (Hsf), but our results demonstrate an unexpected regulatory link between the oxygen-sensing and heat shock pathways.	Oxygen	129-135	interleukin 6	Homo sapiens	34-51
17040902-2	2006	Hsps are known to be regulated by heat shock factor (Hsf), but our results demonstrate an unexpected regulatory link between the oxygen-sensing and heat shock pathways.	Oxygen	129-135	interleukin 6	Homo sapiens	53-56
17166265-1	2006	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) plays an essential role in oxygen homeostasis.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	Oxygen	130-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	Oxygen	167-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-5	2006	100 mV is observed for O2 reduction at an EPG electrode coated with the Co(II)/Pt(II) porphyrin which has been oxidized in 1.0 M HClO4.	Oxygen	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
17117223-6	2006	In addition to the added electrocatalysis a significant percentage of O2 reduced at the oxidized Co(II)/Pt(II) EPG electrode is converted to H2O as determined by rotating disk electrode measurements.	Oxygen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
17149846-10	2006	In this respect, the competition between NO2 and O2 is considered: the rate ratios are such to indicate that the NO3 and HO initiated pathways are the major source of nitroarenes.	Oxygen	42-44	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
17166265-1	2006	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) plays an essential role in oxygen homeostasis.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
17161060-14	2006	CONCLUSIONS: In anemic CHF patients, correction of anemia with EPO and oral iron leads to improvement in New York Heart Association status, measured exercise endurance, oxygen use during exercise, renal function and plasma B-type natriuretic peptide levels and reduces the need for hospitalization.	Oxygen	169-175	erythropoietin	Homo sapiens	63-66
17205940-7	2006	Although epoetin use can increase maximal oxygen uptake, its effects on maximal power output are less pronounced than what is generally assumed.	Oxygen	42-48	erythropoietin	Homo sapiens	9-16
17056012-7	2006	Model building studies on the human HIF prolyl hydroxylase 2 showed that the two phenolate oxygen atoms of gallate form a chelate with the active site Fe(2+), while the carboxyl group of gallate forms a strong ionic/hydrogen bonding interaction with Arg383, explaining why nPG, which has an esterified carboxyl group, is unable to inhibit the hydroxylase.	Oxygen	91-97	egl-9 family hypoxia inducible factor 1	Homo sapiens	36-60
17133035-8	2006	These cases demonstrate that beta-APP staining of the brain may not only provide clues as to possible mechanisms of death in pediatric forensic cases but may indicate a need for careful clinical evaluation of subsequent siblings for possible central apnea requiring oxygen therapy.	Oxygen	266-272	amyloid beta precursor protein	Homo sapiens	29-37
17172857-2	2006	Under hypoxic conditions, transcription of a large group of genes relevant for oxygen homeostasis is induced by the hypoxia-inducible factor-1 (HIF-1).	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-142
17034877-1	2006	The discovery of the colocalization of catalase with H2O2-generating oxidases in peroxisomes was the first indication of their involvement in the metabolism of oxygen metabolites.	Oxygen	160-166	catalase	Mus musculus	39-47
17109460-1	2006	The ongoing interest in very efficient systems for the imitation of cytochrome P-450-dependent monooxygenase reactions, consisting of metalloporphyrin and oxygen donor, prompted us to develop a method to compare the catalytic activity of soluble metalloporphyrins with those which have been immobilised on different silica surfaces.	Oxygen	99-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-84
17213686-5	2006	Furthermore, significant elevations in oxygen consumption were observed in the TGF-beta group during both light and dark phase.	Oxygen	39-45	transforming growth factor, beta 1	Rattus norvegicus	79-87
17172857-2	2006	Under hypoxic conditions, transcription of a large group of genes relevant for oxygen homeostasis is induced by the hypoxia-inducible factor-1 (HIF-1).	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-149
17172857-4	2006	The stability of HIF-1alpha protein is also target of O2 regulation.	Oxygen	54-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
17168650-5	2006	Abeta-mediated mitochondrial stress was evidenced by impaired oxygen consumption and decreased respiratory chain complexes III and IV activities in brains from AD patients and AD-type transgenic mouse model.	Oxygen	62-68	amyloid beta precursor protein	Homo sapiens	0-5
16928196-2	2006	This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply.	Oxygen	140-146	vascular endothelial growth factor A	Homo sapiens	50-54
17056198-4	2006	RESULTS: OM-174 activated the production of IFN-gamma at high levels that reached 70 ng/mL in normoxia (21% oxygen) and 27 ng/mL in tumor-relevant hypoxia (1% oxygen).	Oxygen	108-114	interferon gamma	Mus musculus	44-53
16928196-2	2006	This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply.	Oxygen	140-146	vascular endothelial growth factor A	Homo sapiens	56-90
17209524-2	2006	Hypoxia-inducible factor (HIF)-1, a transcription factor upregulated in hypoxia, orchestrates a range of adaptive responses that allow tumor cells to survive oxygen deprivation.	Oxygen	158-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
17056198-4	2006	RESULTS: OM-174 activated the production of IFN-gamma at high levels that reached 70 ng/mL in normoxia (21% oxygen) and 27 ng/mL in tumor-relevant hypoxia (1% oxygen).	Oxygen	159-165	interferon gamma	Mus musculus	44-53
17112259-2	2006	Efficient electron transfer (&gt;19%) is observed with CS2, NH3, C6F6, NO2, NO*, and C6H6, molecular addition occurs with D2O, CH4, CH3F, CH3Cl, and OCS, and SF6, CO, CO2, N2O, and O2 showed no measurable reactivity with Hg*+.	Oxygen	72-74	chorionic somatomammotropin hormone 2	Homo sapiens	55-58
17097641-3	2006	Here we investigated the effect of the Th2 type cytokines IL-4 and IL-10 on HIF-1alpha mediated response in normoxia (21% O2) and hypoxia (1% O2).	Oxygen	122-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
17097641-3	2006	Here we investigated the effect of the Th2 type cytokines IL-4 and IL-10 on HIF-1alpha mediated response in normoxia (21% O2) and hypoxia (1% O2).	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
17164661-0	2006	Ca2+ ion accumulation precedes formation of O2-* in isolated brain mitochondria.	Oxygen	44-46	carbonic anhydrase 2	Rattus norvegicus	0-3
17164661-7	2006	Mitochondrial Ca2+ accumulation obeyed similar [Ca2+] dependence but shorter t(1/2) (2.5+/-0.3 ms), providing kinetic evidence for Ca2+ accumulation-dependent primary formation of O2-* in brain mitochondria.	Oxygen	180-182	carbonic anhydrase 2	Rattus norvegicus	14-17
17123436-8	2006	Rgs16 is expressed in periportal hepatocytes, the oxygen-rich zone of the liver where lipolysis and gluconeogenesis predominates.	Oxygen	50-56	regulator of G-protein signaling 16	Mus musculus	0-5
17054949-6	2006	A T-DNA knockout mutant of Prx Q did not show any visible phenotype and had normal photosynthetic performance with a slightly increased oxygen evolving activity.	Oxygen	136-142	Thioredoxin superfamily protein	Arabidopsis thaliana	27-32
17415966-8	2006	RESULTS: Incubation of human retinal glial cells at low oxygen concentration for 24 hours lead to HIF-lalpha expression and a significant increase of VEGF released to the media[ (319.	Oxygen	56-62	vascular endothelial growth factor A	Homo sapiens	150-154
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	23-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-58
17067582-1	2006	Hypoxia inducible factor-1alpha (HIF1alpha) plays a key role in the regulation of genes controlling oxygen supply, glucose metabolism and angiogenesis.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
17067582-1	2006	Hypoxia inducible factor-1alpha (HIF1alpha) plays a key role in the regulation of genes controlling oxygen supply, glucose metabolism and angiogenesis.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
17078950-14	2006	These studies show that the recombinant L-chain apoferritin and its mutant are able to demetallate haemin to give a hydroxyethyl protoporphyrin IX derivative in a dimeric form [Macieira, S., Martins, B. M. and Huber, R. (2003) Oxygen-dependent coproporphyrinogen IX oxidase from Escherichia coli: one-step purification and biochemical characterization.	Oxygen	227-233	ferritin heavy chain	Equus caballus	48-59
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	23-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	23-25	erythropoietin	Homo sapiens	82-96
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	23-25	erythropoietin	Homo sapiens	98-101
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	169-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-58
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	169-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	169-171	erythropoietin	Homo sapiens	82-96
17090665-2	2006	In response to reduced O2, hypoxia-inducible factor 1alpha (HIF-1alpha) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O2 deficiency.	Oxygen	169-171	erythropoietin	Homo sapiens	98-101
17090665-3	2006	Epo produced by the kidney stimulates erythrocyte production, leading to decreased HIF-1alpha production by improved tissue O2 delivery.	Oxygen	124-126	erythropoietin	Homo sapiens	0-3
17047453-4	2006	We studied nondemented apolipoprotein E-epsilon4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance.	Oxygen	118-124	apolipoprotein E	Homo sapiens	23-48
17028918-2	2006	The principle is based on an enzymatic reaction between catalase and H2O2 to release O2, thus to increase the O2 amount in the enzyme matrix.	Oxygen	71-73	catalase	Homo sapiens	56-64
17076683-8	2006	TNFalpha also diminished oxygen uptake.	Oxygen	25-31	tumor necrosis factor	Rattus norvegicus	0-8
16997880-0	2006	Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells.	Oxygen	0-6	caveolin 1	Homo sapiens	14-24
16997880-1	2006	We determined the effect of oxygen [approximately 100 Torr (normoxia) and approximately 30-40 Torr (hypoxia)] on functions of endothelial nitric oxide (NO) synthase (NOS-3) and its negative regulator caveolin-1 in ovine fetal and neonatal lung microvascular endothelial cells (MVECs).	Oxygen	28-34	nitric oxide synthase 3	Homo sapiens	166-171
16997880-9	2006	These data support our hypothesis that increased Po(2) at birth promotes dissociation of caveolin-1 and NOS-3, with an increase in their activities, and that PKC and an oxygen-sensitive cell surface G protein-coupled receptor regulate caveolin-1 and NOS-3 interactions in fetal and neonatal lung MVECs.	Oxygen	169-175	caveolin 1	Homo sapiens	89-99
16997880-9	2006	These data support our hypothesis that increased Po(2) at birth promotes dissociation of caveolin-1 and NOS-3, with an increase in their activities, and that PKC and an oxygen-sensitive cell surface G protein-coupled receptor regulate caveolin-1 and NOS-3 interactions in fetal and neonatal lung MVECs.	Oxygen	169-175	caveolin 1	Homo sapiens	235-245
16997880-9	2006	These data support our hypothesis that increased Po(2) at birth promotes dissociation of caveolin-1 and NOS-3, with an increase in their activities, and that PKC and an oxygen-sensitive cell surface G protein-coupled receptor regulate caveolin-1 and NOS-3 interactions in fetal and neonatal lung MVECs.	Oxygen	169-175	nitric oxide synthase 3	Homo sapiens	250-255
17028918-2	2006	The principle is based on an enzymatic reaction between catalase and H2O2 to release O2, thus to increase the O2 amount in the enzyme matrix.	Oxygen	85-87	catalase	Homo sapiens	56-64
17111303-8	2006	In all the groups, the maximal oxygen consumption/kg correlated positively with basal levels of testosterone (r=0.60, p&lt;0.001) and insulin (r=0.34), and negatively to ghrelin (r=-0.35) and leptin (r=-0.32) (p&lt;0.05).	Oxygen	31-37	insulin	Homo sapiens	134-141
16980385-2	2006	The stability of the C. elegans HIF-1 protein is controlled by the evolutionarily conserved EGL-9/VHL-1 pathway for oxygen-dependent degradation.	Oxygen	116-122	Hypoxia-inducible factor 1	Caenorhabditis elegans	32-37
30754154-4	2006	From recombinant erythropoietin to synthetic hemoglobin, all the developed tools are potentially useful to increase the oxygen transport to peripheral tissues in endurance athletes.	Oxygen	120-126	erythropoietin	Homo sapiens	17-31
17065516-0	2006	Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy.	Oxygen	109-115	insulin like growth factor 1	Homo sapiens	64-69
17016618-4	2006	We demonstrated that pretreatment with sTNFRI, for inducing reverse signaling through mTNF-alpha, sensitized U937 cells to sTNF-alpha stimulation, as evidenced by an increase in reactive oxygen production and mRNA levels of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-8) in these cells.	Oxygen	187-193	tumor necrosis factor	Mus musculus	86-96
17016618-4	2006	We demonstrated that pretreatment with sTNFRI, for inducing reverse signaling through mTNF-alpha, sensitized U937 cells to sTNF-alpha stimulation, as evidenced by an increase in reactive oxygen production and mRNA levels of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-8) in these cells.	Oxygen	187-193	tumor necrosis factor	Homo sapiens	87-96
17065527-11	2006	CONCLUSIONS: Inhibition of TNFalpha via TNF-Rp55 can alter retinal development and angiogenesis in a model of oxygen-induced retinopathy.	Oxygen	110-116	tumor necrosis factor	Mus musculus	27-35
17065527-11	2006	CONCLUSIONS: Inhibition of TNFalpha via TNF-Rp55 can alter retinal development and angiogenesis in a model of oxygen-induced retinopathy.	Oxygen	110-116	tumor necrosis factor	Mus musculus	27-30
17065527-12	2006	The data underscore the potential effectiveness of TNF-inhibitory treatments as modulators in oxygen-induced retinopathy.	Oxygen	94-100	tumor necrosis factor	Mus musculus	51-54
17065527-3	2006	This study was conducted to investigate the effect of TNF-Rp55 and TNF-Rp75 on retinal development in oxygen-induced retinopathy.	Oxygen	102-108	tumor necrosis factor	Mus musculus	54-57
16887934-2	2006	The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-76
17119284-2	2006	Furthermore, metal ions such as zinc and copper can interact with both AbetaPP and Abeta to potentiate Alzheimer"s disease by participating in the aggregation of these normal cellular proteins and in the generation of reactive oxygen species.	Oxygen	227-233	amyloid beta precursor protein	Homo sapiens	71-78
17119284-2	2006	Furthermore, metal ions such as zinc and copper can interact with both AbetaPP and Abeta to potentiate Alzheimer"s disease by participating in the aggregation of these normal cellular proteins and in the generation of reactive oxygen species.	Oxygen	227-233	amyloid beta precursor protein	Homo sapiens	71-76
16930622-1	2006	BACKGROUND: We have recently shown that attenuation of sepsis-induced lung injury by hyperbaric oxygen (HBO) pretreatment involves expression regulation of inducible nitric oxide synthase (iNOS) and heme oxygenase (HO)-1.	Oxygen	96-102	nitric oxide synthase 2	Rattus norvegicus	156-187
16930622-1	2006	BACKGROUND: We have recently shown that attenuation of sepsis-induced lung injury by hyperbaric oxygen (HBO) pretreatment involves expression regulation of inducible nitric oxide synthase (iNOS) and heme oxygenase (HO)-1.	Oxygen	96-102	nitric oxide synthase 2	Rattus norvegicus	189-193
16788740-9	2006	Changes in grp78 gene and protein expression appear to aid stress tolerance in two highly oxygen-dependent organs that are critical to whole animal survival during hibernation.	Oxygen	90-96	endoplasmic reticulum chaperone BiP	Ictidomys tridecemlineatus	11-16
17256467-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17256467-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16887934-2	2006	The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-83
16887934-5	2006	In normoxia, hydroxylation of two proline residues and acetylation of a lysine residue at the oxygen-dependent degradation domain (ODDD) of HIF-1alpha trigger its association with pVHL E3 ligase complex, leading to HIF-1alpha degradation via ubiquitin-proteasome pathway.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-150
16887934-5	2006	In normoxia, hydroxylation of two proline residues and acetylation of a lysine residue at the oxygen-dependent degradation domain (ODDD) of HIF-1alpha trigger its association with pVHL E3 ligase complex, leading to HIF-1alpha degradation via ubiquitin-proteasome pathway.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	215-225
17132228-5	2006	Here, we demonstrate that oxygen-dependent recognition of HIFalpha by VHL triggers Rbx1-dependent neddylation of Cul2, which preferentially engages the E2 ubiquitin-conjugating enzyme UbcH5a.	Oxygen	26-32	cullin 2	Homo sapiens	113-117
17294836-3	2006	Thus, the purpose of this study was to explore the effects of intermittent hypoxia (8 h at 12 % O2 per day) for 0, 7 or 14 days on inducible nitric oxide synthase (iNOS) expression in the spleen and on splenic calcium response to the mitogen phytohemagglutinin (PHA).	Oxygen	96-98	nitric oxide synthase 2	Rattus norvegicus	164-168
16917908-4	2006	Specifically, the dimanganese form of DF1 is a mimic of the natural enzyme manganese catalase, which catalyzes the dismutation reaction of hydrogen peroxide into water and oxygen.	Oxygen	172-178	catalase	Homo sapiens	85-93
17150152-6	2006	HIF-1, consisting of HIF-1alpha and HIF-1beta subunits, is a major transcription factor that functions as a master regulator of oxygen homeostasis that plays essential roles in cellular and systemic pathophysiology.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
17150152-7	2006	HIF-1alpha expression and HIF-1 transcriptional activity increase exponentially as cellular oxygen concentration is decreased.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
17150152-7	2006	HIF-1alpha expression and HIF-1 transcriptional activity increase exponentially as cellular oxygen concentration is decreased.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
17031957-2	2006	The new probe is highly water soluble with a large stability constant of approximately 10(21) and a wide pH available range (pH 3-10), and can specifically react with (1)O2 to form its endoperoxide (EP-MTTA-Eu(3+)) with a high reaction rate constant at 10(10) M(-1) s(-1), accompanied by the remarkable increases of luminescence quantum yield from 0.90% to 13.8% and lifetime from 0.80 to 1.29 ms, respectively.	Oxygen	167-172	mitochondrially encoded tRNA alanine	Homo sapiens	202-206
17236590-4	2006	RESULTS: Under the condition of normal concentration oxygen, P53 was highly expressed in the placenta of pregnant women with ICP (P &lt; 0.01), however the HIF-1alpha expression was not up to higher than in normal control.	Oxygen	53-59	tumor protein p53	Homo sapiens	61-64
17236590-5	2006	Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P &lt; 0.05 and P &lt; 0.001 respectively).	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
17236590-5	2006	Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P &lt; 0.05 and P &lt; 0.001 respectively).	Oxygen	43-49	tumor protein p53	Homo sapiens	78-81
17236590-5	2006	Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P &lt; 0.05 and P &lt; 0.001 respectively).	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	209-219
17236590-5	2006	Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P &lt; 0.05 and P &lt; 0.001 respectively).	Oxygen	54-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
17236590-5	2006	Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P &lt; 0.05 and P &lt; 0.001 respectively).	Oxygen	54-56	tumor protein p53	Homo sapiens	78-81
17004712-14	2006	Taken together, these results support the hypothesis that it is the carboxamide oxygen of the C-3 substituent of 1 that engages in a hydrogen bond with K3.28(192) in WT CB1.	Oxygen	80-86	cannabinoid receptor 1	Homo sapiens	169-172
16627691-10	2006	This oxygen-induced effect is mediated via the transcription factor HIF-1.	Oxygen	5-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-73
16682946-1	2006	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen tension.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
16682946-1	2006	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen tension.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
16682946-1	2006	Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to low oxygen tension.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-39
16520989-8	2006	In addition, in 20% O2, but not in 2% O2, 4-HPR obviously downregulated the protein expression of procaspase-3, ERK1/2 and XIAP, and increased the cleavage of PARP.	Oxygen	20-22	caspase 3	Homo sapiens	98-110
17111008-6	2006	This was further supported by the fact that 7 tests exhibited peak oxygen uptake values over 100 mL.min(-1) (&gt;or= 3%) lower than the peak values attained in the incremental phase.	Oxygen	67-73	CD59 molecule (CD59 blood group)	Homo sapiens	100-106
17469342-8	2006	The glucose-insulin-potassium solution provides the glucose needed by the myocardium in reperfusion conditions and protects the cellular membrane"s integrity as well as pumps and ionic channels, it allows maintaining the action potential probably because ATP-depended channels block and prevent potassium loss, it reduces the cytosol calcium overload and prevent cardiac arrhythmias, preserves the sodium ATPasa pump avoiding the rise in cytosolic sodium; glucose prevents the production of free oxygen radicals.	Oxygen	496-502	insulin	Homo sapiens	12-19
17015940-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
17015940-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16873387-4	2006	RESULTS: The rate of oxygen desaturation of haemoglobin from 90 to 40% was similar across the ages studied, being approximately 30% min(-1).	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	132-138
16978312-3	2006	The common approach of inserting a 14-gauge cannula and using low-pressure ventilation via intermittent occlusion of an opening in oxygen tubing (15 l x min(-1) flow) results in ineffective ventilation within 60 s or less, depending on the degree of airway obstruction.	Oxygen	131-137	CD59 molecule (CD59 blood group)	Homo sapiens	153-159
16520989-8	2006	In addition, in 20% O2, but not in 2% O2, 4-HPR obviously downregulated the protein expression of procaspase-3, ERK1/2 and XIAP, and increased the cleavage of PARP.	Oxygen	20-22	mitogen-activated protein kinase 3	Homo sapiens	112-118
17073607-0	2006	From the oxygen to the organ protection: erythropoietin as protagonist in internal medicine.	Oxygen	9-15	erythropoietin	Homo sapiens	41-55
17002676-7	2006	The abundance and activity of HIF-1, a heterodimer of an alpha- and beta-subunit, is predominantly regulated by oxygen-dependent post-translational hydroxylation of the alpha-subunit.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35
17002676-12	2006	In addition to the tight regulation by oxygen tension, temporal and tissue-specific signals limit expression of the EPO gene primarily to the fetal liver and the adult kidney.	Oxygen	39-45	erythropoietin	Homo sapiens	116-119
16999507-4	2006	Significant differences in density and oxygen-oxygen radial distribution functions are found between the predictions of the SPC/E, TIP5P, and the models of the TIP4P family.	Oxygen	39-45	proline rich protein gene cluster	Homo sapiens	124-127
16826568-8	2006	In summary, we demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia.	Oxygen	167-173	inorganic pyrophosphatase 1	Homo sapiens	74-82
17014551-1	2006	AIM: To evaluate whether factors such as acidosis and hyperphosphataemia that might cause an increased oxygen delivery to tissues could result in increased dosing requirements for intravenous erythropoietin (EPO) administration given to haemodialysis patients.	Oxygen	103-109	erythropoietin	Homo sapiens	192-206
17014551-1	2006	AIM: To evaluate whether factors such as acidosis and hyperphosphataemia that might cause an increased oxygen delivery to tissues could result in increased dosing requirements for intravenous erythropoietin (EPO) administration given to haemodialysis patients.	Oxygen	103-109	erythropoietin	Homo sapiens	208-211
17014551-12	2006	While this study did not evaluate the mechanism of such requirements and indeed many mechanisms might be possible, a rightward shift in the oxygen-haemoglobin dissociation curve resulting in down-regulation of erythropoietin receptors is considered consistent with the data and present knowledge.	Oxygen	140-146	erythropoietin	Homo sapiens	210-224
16932233-0	2006	Hyperbaric oxygen protects from sepsis mortality via an interleukin-10-dependent mechanism.	Oxygen	11-17	interleukin 10	Mus musculus	56-70
17144261-3	2006	The volumetric oxygen transfer coefficient (kLa) values for superficial air velocities between 8.4 cm min(-1) and 57.0 cm min(-1) varied from 20.8 h(-1) to 58.8 h(-1) for tap water, and 16.8 h(-1) to 53.0 h(-1) for the anaerobic pre-treated effluent.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	102-108
17144261-3	2006	The volumetric oxygen transfer coefficient (kLa) values for superficial air velocities between 8.4 cm min(-1) and 57.0 cm min(-1) varied from 20.8 h(-1) to 58.8 h(-1) for tap water, and 16.8 h(-1) to 53.0 h(-1) for the anaerobic pre-treated effluent.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	122-128
16511503-6	2006	In addition, pharmacological blockade of the phosphoinositide 3-kinase (PI3K)/Akt pathway reduced cell death induced by oxygen and glucose deprivation (OGD) and increased the protective effect of preconditioning (PC).	Oxygen	120-126	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-83
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-90
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	erythropoietin	Homo sapiens	93-107
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	erythropoietin	Homo sapiens	109-112
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	vascular endothelial growth factor A	Homo sapiens	118-152
16963303-1	2006	Accumulating studies demonstrate that the expressions of hypoxia-inducible factor 1 (HIF-1), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) depend on cellular oxygen tension, which is involved in the pathological process of tissue hypoxia and/or ischemia.	Oxygen	179-185	vascular endothelial growth factor A	Homo sapiens	154-158
17096698-3	2006	In the present study, we examined whether the performance of DHP-PMX improved tissue oxygen metabolism in patients with sepsis.	Oxygen	85-91	dihydropyrimidinase	Homo sapiens	61-64
17096698-10	2006	These findings suggest that DHP-PMX improves tissue oxygen metabolism.	Oxygen	52-58	dihydropyrimidinase	Homo sapiens	28-31
16999507-4	2006	Significant differences in density and oxygen-oxygen radial distribution functions are found between the predictions of the SPC/E, TIP5P, and the models of the TIP4P family.	Oxygen	46-52	proline rich protein gene cluster	Homo sapiens	124-127
16782283-5	2006	While oxygen, serum and glucose deprivation triggered the most rapid release of S100B, serum and glucose deprivation provoked comparable levels of released S100B at the later time points.	Oxygen	6-12	S100 calcium binding protein B	Homo sapiens	80-85
16782283-8	2006	Interestingly, S100B mRNA expression was potently downregulated after 12 and 24 h of oxygen, serum and glucose deprivation, and prolonged oxygen, serum and glucose deprivation for 48 h was associated with a significant reduction of S100B release at later time intervals, whereas lactate dehydrogenase levels remained constant.	Oxygen	85-91	S100 calcium binding protein B	Homo sapiens	15-20
16782283-8	2006	Interestingly, S100B mRNA expression was potently downregulated after 12 and 24 h of oxygen, serum and glucose deprivation, and prolonged oxygen, serum and glucose deprivation for 48 h was associated with a significant reduction of S100B release at later time intervals, whereas lactate dehydrogenase levels remained constant.	Oxygen	138-144	S100 calcium binding protein B	Homo sapiens	15-20
16782283-8	2006	Interestingly, S100B mRNA expression was potently downregulated after 12 and 24 h of oxygen, serum and glucose deprivation, and prolonged oxygen, serum and glucose deprivation for 48 h was associated with a significant reduction of S100B release at later time intervals, whereas lactate dehydrogenase levels remained constant.	Oxygen	138-144	S100 calcium binding protein B	Homo sapiens	232-237
16847060-0	2006	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	Oxygen	73-79	mechanistic target of rapamycin kinase	Homo sapiens	4-33
16780822-3	2006	This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.	Oxygen	137-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-177
16847060-0	2006	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	Oxygen	73-79	mechanistic target of rapamycin kinase	Homo sapiens	35-39
16847060-3	2006	Here we demonstrate that in mammalian cells the mammalian TOR (mTOR) pathway plays a significant role in determining both resting oxygen consumption and oxidative capacity.	Oxygen	130-136	mechanistic target of rapamycin kinase	Homo sapiens	63-67
16847060-5	2006	Disruption of this complex following treatment with the mTOR pharmacological inhibitor rapamycin lowered mitochondrial membrane potential, oxygen consumption, and ATP synthetic capacity.	Oxygen	139-145	mechanistic target of rapamycin kinase	Homo sapiens	56-60
16847054-3	2006	We further demonstrated that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor (HIF)-1alpha up-regulation in EGF-treated cancer cells.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-139
16793356-8	2006	Only at these intermediate levels of ligand conditioning, did the presence of an extra oxygen atom in the backbone of poly(DTD diglycolate) relative to poly(DTD glutarate) (i) alter the overall organization/concentration of the fibronectin; (ii) weaken cell attachment strength and inhibited excessive cell spreading; and (iii) promote cell motility kinetics.	Oxygen	87-93	fibronectin 1	Homo sapiens	228-239
16617125-3	2006	In isolated mitochondria without exogenous substrates, addition of catalase and the membrane-permeant reducing agent N-acetylcysteine (Nac) or the ROS scavenger mercaptopropionyl glycine significantly increased the ability to phosphorylate added ADP, as demonstrated by 1) full recovery of membrane potential (Deltapsi) and matrix volume from ADP-induced dissipation and shrinkage, 2) ADP-dependent increase in O2 consumption, and 3) enhanced rate of ATP synthesis.	Oxygen	411-413	catalase	Homo sapiens	67-75
16617125-4	2006	Removal of extramitochondrial H2O2 by catalase was required to stimulate endogenous substrate oxidation, as shown by the increase in O2 consumption and Deltapsi.	Oxygen	32-34	catalase	Homo sapiens	38-46
17017857-2	2006	The cytotoxic effects of these quinones are mainly due to the following two factors: (i) inhibition of DNA topoisomerase-II and, (ii) formation of semiquinone radical that can transfer an electron to oxygen to produce super oxide, which is catalyzed by flavoenzymes such as NADPH-cytochrome-P-450 reductase.	Oxygen	200-206	cytochrome p450 oxidoreductase	Homo sapiens	274-306
16615111-8	2006	UV-visible absorption spectra suggest that three nitrogen donor ligands and one oxygen donor ligand (3N1O) in Abeta(1-16) may form a type II square-planar coordination geometry with Cu2+.	Oxygen	80-86	amyloid beta precursor protein	Homo sapiens	110-115
16934676-7	2006	In the present study we verified that the addition of EDTA eliminates completely the effect of excess copper on the decomposition rate of O2*- in the presence of Cu,Zn-SOD.	Oxygen	138-141	superoxide dismutase 1	Homo sapiens	162-171
16971531-0	2006	The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.	Oxygen	86-92	erythropoietin	Homo sapiens	117-131
16455769-9	2006	In response to cage-switch stress, the increase in oxygen consumption at both 30 and 20 degrees C was lower in IL-6-/- than in wild-type mice.	Oxygen	51-57	interleukin 6	Mus musculus	111-115
16455769-10	2006	The increase in heart rate was lower in IL-6-/- mice at 30 degrees C. At 4 degrees C, both the oxygen consumption and core temperature were lower in IL-6-/- compared with wild-type mice, suggesting a lower cold-induced thermogenesis in IL-6-/- mice.	Oxygen	95-101	interleukin 6	Mus musculus	40-44
16455769-10	2006	The increase in heart rate was lower in IL-6-/- mice at 30 degrees C. At 4 degrees C, both the oxygen consumption and core temperature were lower in IL-6-/- compared with wild-type mice, suggesting a lower cold-induced thermogenesis in IL-6-/- mice.	Oxygen	95-101	interleukin 6	Mus musculus	149-153
16455769-10	2006	The increase in heart rate was lower in IL-6-/- mice at 30 degrees C. At 4 degrees C, both the oxygen consumption and core temperature were lower in IL-6-/- compared with wild-type mice, suggesting a lower cold-induced thermogenesis in IL-6-/- mice.	Oxygen	95-101	interleukin 6	Mus musculus	149-153
16966147-5	2006	VEGF expression, determined by real-time polymerase chain reaction (PCR) for mRNA and ELISA for protein, was determined after exposure to 24 h of 1% oxygen.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	0-4
17699326-0	2006	Properties permitting the renal cortex to be the oxygen sensor for the release of erythropoietin: clinical implications.	Oxygen	49-55	erythropoietin	Homo sapiens	82-96
16939503-8	2006	The tissue sensitivity to insulin increased 32% (P = 0.03) with oxygen supplementation.	Oxygen	64-70	insulin	Homo sapiens	26-33
16939503-9	2006	The results indicate that normalization of oxygen saturation in COPD patients with chronic hypoxaemia may have an immediate effect on glucose tolerance and tissue sensitivity to insulin in these patients.	Oxygen	43-49	insulin	Homo sapiens	178-185
17033273-6	2006	The change in O2 consumption was significantly correlated with the degree of beta1-blockade (r =0.45; P&lt;.05).	Oxygen	14-16	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	77-82
16820303-2	2006	The ESI mass spectrum of angiotensin II following exposure to ozone showed the formation of adducts containing one, three, and four oxygen atoms.	Oxygen	132-138	angiotensinogen	Homo sapiens	25-39
16750526-7	2006	Oxygen plays the key role in stabilizing HIF-1alpha and its function.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
16750526-8	2006	When the oxygen tension is normal, HIF-1alpha is rapidly oxidized by hydroxylase enzymes, but when cells become hypoxic, HIF-1alpha escapes the degradation and starts to accumulate, triggering the activation of a large number of genes, like vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
16750526-8	2006	When the oxygen tension is normal, HIF-1alpha is rapidly oxidized by hydroxylase enzymes, but when cells become hypoxic, HIF-1alpha escapes the degradation and starts to accumulate, triggering the activation of a large number of genes, like vascular endothelial growth factor (VEGF) and erythropoietin.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-131
16750526-9	2006	HIF-1alpha has been shown to have, either clinically or experimentally, a mediating or contributing role in several oxygen-dependent retinal diseases such as von Hippel-Lindau, proliferative diabetic retinopathy, retinopathy of prematurity and glaucoma.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
17122956-3	2006	Under the conditions of oxidative stress, superoxide dismutase (SOD) acts as an endogenous cellular defense system to degrade superoxide (O2-) into oxygen and hydrogen peroxide.	Oxygen	138-140	superoxide dismutase 1	Homo sapiens	42-62
17122956-3	2006	Under the conditions of oxidative stress, superoxide dismutase (SOD) acts as an endogenous cellular defense system to degrade superoxide (O2-) into oxygen and hydrogen peroxide.	Oxygen	138-140	superoxide dismutase 1	Homo sapiens	64-67
17122956-3	2006	Under the conditions of oxidative stress, superoxide dismutase (SOD) acts as an endogenous cellular defense system to degrade superoxide (O2-) into oxygen and hydrogen peroxide.	Oxygen	148-154	superoxide dismutase 1	Homo sapiens	42-62
17122956-3	2006	Under the conditions of oxidative stress, superoxide dismutase (SOD) acts as an endogenous cellular defense system to degrade superoxide (O2-) into oxygen and hydrogen peroxide.	Oxygen	148-154	superoxide dismutase 1	Homo sapiens	64-67
16815840-2	2006	Even though HIF-1 is highly regulated by cellular oxygen levels, other elements of the inflammatory and tumor microenvironment were shown to influence its activity under normal oxygen concentration.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-17
16914311-6	2006	These versions suggest that some cytochrome P-450"s catalyze the introduction of both oxygen atoms of dioxygen into an appropriate sterol precursor.	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-49
16914311-6	2006	These versions suggest that some cytochrome P-450"s catalyze the introduction of both oxygen atoms of dioxygen into an appropriate sterol precursor.	Oxygen	102-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-49
16914311-9	2006	Central to these new renditions is the hypothesis that the appropriate P-450 introduces dioxygen into the precursor yielding either: A, a 20 peroxy sterol species or B, a species oxygenated at both C-17 and C-20 or C, a species oxygenated at both C-20 and C-21.	Oxygen	88-96	TBL1X/Y related 1	Homo sapiens	256-260
16790533-6	2006	Although NQO1 protected against dopamine-induced proteasomal inhibition, the metabolism of aminochrome by NQO1 led to oxygen uptake because of the generation of a redox-labile cyclized hydroquinone, further demonstrating the lack of involvement of oxygen radicals in proteasomal inhibition.	Oxygen	118-124	NAD(P)H quinone dehydrogenase 1	Homo sapiens	106-110
16772346-5	2006	Perfusion and oxidative capacity were measured during insulin stimulation by [15O]H2O and [15O]O2.	Oxygen	95-97	insulin	Homo sapiens	54-61
16793304-5	2006	C2C12 cells with Bcl-2Delta consistently produced more protein regardless of the oxygen level or promoter used.	Oxygen	81-87	B cell leukemia/lymphoma 2	Mus musculus	17-22
16973514-9	2006	CONCLUSION: In CRF patients there is a negative correlation between FR(Na) and EPO dose, which supports the hypothesis that EPO deficiency may be related to the decreased renal oxygen-consuming work of sodium reabsorption.	Oxygen	177-183	erythropoietin	Homo sapiens	79-82
16973514-9	2006	CONCLUSION: In CRF patients there is a negative correlation between FR(Na) and EPO dose, which supports the hypothesis that EPO deficiency may be related to the decreased renal oxygen-consuming work of sodium reabsorption.	Oxygen	177-183	erythropoietin	Homo sapiens	124-127
16815840-2	2006	Even though HIF-1 is highly regulated by cellular oxygen levels, other elements of the inflammatory and tumor microenvironment were shown to influence its activity under normal oxygen concentration.	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-17
16815840-6	2006	As a consequence, the degradation of HIF-1alpha was inhibited as determined by impaired degradation of a reporter protein containing the HIF-1alpha oxygen-dependent degradation domain encompassing the PHD-targeted prolines.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
16815840-6	2006	As a consequence, the degradation of HIF-1alpha was inhibited as determined by impaired degradation of a reporter protein containing the HIF-1alpha oxygen-dependent degradation domain encompassing the PHD-targeted prolines.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
16893217-1	2006	A joint experimental and theoretical approach has been developed to study oxygen atom recombination on a beta-quartz surface.	Oxygen	74-80	amyloid beta precursor protein	Homo sapiens	103-109
16893705-5	2006	However, the model that included the circulatory power (peak oxygen uptake x systolic blood pressure), in addition to age, New York Heart Association class, and left ventricular ejection fraction, was the best 1 for patients on beta-blocker therapy.	Oxygen	61-67	bestrophin 1	Homo sapiens	205-211
16760477-0	2006	Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-65
16899821-0	2006	A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-86
16899821-2	2006	We developed a computational model to gain a detailed quantitative understanding of how HIF1 acts to sense oxygen and respond to hypoxia.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-92
16899821-4	2006	We tested an existing hypothesis of a switch-like change in HIF1 expression in response to a gradual decrease in O2 concentration.	Oxygen	113-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-64
16899821-6	2006	We show HIF1-activated cellular responses can be divided into two categories: a steep, switch-like response to O2 and a gradual one.	Oxygen	111-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-12
16760477-1	2006	The hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of target genes associated with numerous processes, including vascularization and glycolysis.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-41
16766528-7	2006	Furthermore, we have also identified a new Cys-type sulfatase-maturating enzyme that catalyzes the conversion of cysteine into FGly, in anaerobic conditions, whereas the only enzyme reported so far to be able to catalyze this reaction is oxygen-dependent.	Oxygen	238-244	arylsulfatase family member H	Homo sapiens	52-61
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Oxygen	261-267	lactoperoxidase	Homo sapiens	485-488
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Oxygen	261-267	lactoperoxidase	Homo sapiens	500-503
16547490-0	2006	Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation.	Oxygen	74-80	ETS variant transcription factor 6	Homo sapiens	27-30
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Oxygen	352-358	lactoperoxidase	Homo sapiens	485-488
16547490-4	2006	In low oxygen tension conditions, the HIF1alpha/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity.	Oxygen	7-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-47
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Oxygen	352-358	lactoperoxidase	Homo sapiens	500-503
16547490-4	2006	In low oxygen tension conditions, the HIF1alpha/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity.	Oxygen	7-13	ETS variant transcription factor 6	Homo sapiens	48-51
16547490-4	2006	In low oxygen tension conditions, the HIF1alpha/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity.	Oxygen	7-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-42
16878955-3	2006	2005, 3165) have synthesized a unique compound of the form Li9O2(hpp)7, with an O2 unit encapsulated in the Li cluster.	Oxygen	62-64	familial progressive hyperpigmentation 1	Homo sapiens	65-68
16547490-5	2006	Differentiation of normal human CD34+ progenitors cells along all the erythrocytic, megakaryocytic and granulocytic pathways was accelerated in low versus high oxygen tension conditions.	Oxygen	160-166	CD34 molecule	Homo sapiens	32-36
16884302-5	2006	While retention of the maleimide ring and pendant 4-phenyl group is necessary for potency, replacement of the carbazole nitrogen by oxygen is well tolerated and results in improved Wee1 selectivity against the related checkpoint kinase Chk1.	Oxygen	132-138	checkpoint kinase 1	Homo sapiens	236-240
16554418-2	2006	Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation.	Oxygen	46-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
16554418-2	2006	Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation.	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
16877351-3	2006	Exposure of primary human articular chondrocytes to 1% oxygen enhanced accumulation of native type II collagen and stabilized hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-157
16554418-2	2006	Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation.	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
16877351-3	2006	Exposure of primary human articular chondrocytes to 1% oxygen enhanced accumulation of native type II collagen and stabilized hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
16877351-7	2006	mRNA levels of type II collagen (Col2A1) and the beta-subunit (P4HB) of prolyl-4-hydroxylase, however, displayed only modest changes at 1% oxygen.	Oxygen	139-145	collagen type II alpha 1 chain	Homo sapiens	33-39
16861921-1	2006	Hypoxia inducible factor-1 (HIF-1) is a master regulator of cellular adaptation to oxygen deprivation and activates transcription of genes involved in tumor metabolism, angiogenesis, invasion and metastasis, all of which are implicated in cancer progression.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16824482-1	2006	Respiratory heme-copper oxidases are integral membrane proteins that catalyze the reduction of molecular oxygen to water using electrons donated by either quinol (quinol oxidases) or cytochrome c (cytochrome c oxidases, CcOs).	Oxygen	105-111	cytochrome c, somatic	Homo sapiens	183-195
16824482-1	2006	Respiratory heme-copper oxidases are integral membrane proteins that catalyze the reduction of molecular oxygen to water using electrons donated by either quinol (quinol oxidases) or cytochrome c (cytochrome c oxidases, CcOs).	Oxygen	105-111	cytochrome c, somatic	Homo sapiens	197-209
17102090-5	2006	Germline mutations in VHL and HIF1 prolyl hydroxylase 2 genes cause polycythemia consistent with their role in oxygen homeostasis.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-34
16861921-1	2006	Hypoxia inducible factor-1 (HIF-1) is a master regulator of cellular adaptation to oxygen deprivation and activates transcription of genes involved in tumor metabolism, angiogenesis, invasion and metastasis, all of which are implicated in cancer progression.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16843828-4	2006	In cultured skin fibroblasts from human volunteers exposed to high insulin concentration, either in the presence or in the absence of pravastatin, insulin induced translocation of the p47(phox) subunit of NAD(P)H oxidase from the cytosol to the membrane and generation of radical oxygen species through a PKC delta-dependent mechanism.	Oxygen	280-286	insulin	Homo sapiens	147-154
16926105-3	2006	These include both a transcriptional response initiated by oxygen-dependent stabilisation of the HIF-1 transcription factor and an mRNA translational response characterized by activation of the unfolded protein response (UPR) and inhibition of mTOR signalling.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-102
16673399-9	2006	Apoptosis was detected at various stages (annexin-V, activated caspase-3) after 24-48 hr of incubation in 80% oxygen in pre- and immature OLs.	Oxygen	110-116	caspase 3	Homo sapiens	63-72
17015265-2	2006	We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1).	Oxygen	60-62	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	248-284
17015265-2	2006	We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1).	Oxygen	60-62	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	286-290
16849472-11	2006	This new role for ERK in alveolar macrophage homeostasis may help to explain the survival characteristic of these cells within their unique high oxygen and stress microenvironment.	Oxygen	145-151	mitogen-activated protein kinase 1	Homo sapiens	18-21
16757529-1	2006	CONTEXT: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO(2max)).	Oxygen	149-155	insulin	Homo sapiens	9-16
16888453-2	2006	Hypoxia inducible factor-1 (HIF-1) controls the expression of several genes" encoding involved in physiological responses towards reduced oxygen availability, in particular by increasing serum erythropoietin (EPO).	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16873253-3	2006	Here we show that the latency-associated nuclear antigen (LANA), which plays a crucial role in modulating viral and cellular gene expression, directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-223
16873253-3	2006	Here we show that the latency-associated nuclear antigen (LANA), which plays a crucial role in modulating viral and cellular gene expression, directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	225-236
16847924-1	2006	BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in responses to hypoxia and expression of HIF-1alpha downstream genes leads to both an adapted metabolism and increased oxygen supply.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
16847924-1	2006	BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in responses to hypoxia and expression of HIF-1alpha downstream genes leads to both an adapted metabolism and increased oxygen supply.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
16847924-1	2006	BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in responses to hypoxia and expression of HIF-1alpha downstream genes leads to both an adapted metabolism and increased oxygen supply.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
16888453-2	2006	Hypoxia inducible factor-1 (HIF-1) controls the expression of several genes" encoding involved in physiological responses towards reduced oxygen availability, in particular by increasing serum erythropoietin (EPO).	Oxygen	138-144	erythropoietin	Homo sapiens	209-212
16888453-2	2006	Hypoxia inducible factor-1 (HIF-1) controls the expression of several genes" encoding involved in physiological responses towards reduced oxygen availability, in particular by increasing serum erythropoietin (EPO).	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16888453-2	2006	Hypoxia inducible factor-1 (HIF-1) controls the expression of several genes" encoding involved in physiological responses towards reduced oxygen availability, in particular by increasing serum erythropoietin (EPO).	Oxygen	138-144	erythropoietin	Homo sapiens	193-207
16869871-2	2006	Glutathione S-transferases (GSTs) play a primer role in cellular defense against electrophilic chemical species and radical oxygen species.	Oxygen	124-130	glutathione S-transferase mu 1	Homo sapiens	28-32
16848423-10	2006	These anomalous (rare) binding events may account for some of the unique properties associated with the Abeta, such as its proposed "dual role", where sequestration of metal ions by the monomer is neuroprotective, while that by beta-aggregates generates oxygen radicals and causes neuronal death.	Oxygen	254-260	amyloid beta precursor protein	Homo sapiens	104-109
16923368-10	2006	It is speculated that NADPH oxidase as an oxygen sensor regulates the HIF-1alpha expression by changing the intracellular redox reaction and that except HIF-1, H2O2 might contribute to ET-1 synthesis and release.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
16923368-10	2006	It is speculated that NADPH oxidase as an oxygen sensor regulates the HIF-1alpha expression by changing the intracellular redox reaction and that except HIF-1, H2O2 might contribute to ET-1 synthesis and release.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
17039774-7	2006	CONCLUSION: iNOS plays dual roles in 629 metabolism, enhancing or decreasing the cytoxicity of 629 depending on the intracellular oxygen pressure P(O2), which caused higher cytotoxicity to hypoxia cells of 629 with the increasing of iNOS activity.	Oxygen	130-136	nitric oxide synthase 2	Homo sapiens	12-16
17039774-7	2006	CONCLUSION: iNOS plays dual roles in 629 metabolism, enhancing or decreasing the cytoxicity of 629 depending on the intracellular oxygen pressure P(O2), which caused higher cytotoxicity to hypoxia cells of 629 with the increasing of iNOS activity.	Oxygen	148-150	nitric oxide synthase 2	Homo sapiens	12-16
16836315-2	2006	Cadmium vapor generated by the carbothermal reduction of CdO powder in a tube furnace heated to 500 degrees C was carried to the substrate zone by an argon flow with a trace amount of oxygen.	Oxygen	184-190	cell adhesion associated, oncogene regulated	Homo sapiens	57-60
16483558-8	2006	The oxygen-sensitive signaling pathways involved have been characterized and point towards a central role of p21, TGFbeta and p38MAPK.	Oxygen	4-10	transforming growth factor beta 1	Homo sapiens	114-121
16836315-7	2006	Interesting CdO nanowires with a necklace-like morphology were also observed in a small region of the substrate, where the oxygen supply may be ample to facilitate the lateral growth of rhombohedron-shaped crystals over the straight wires.	Oxygen	123-129	cell adhesion associated, oncogene regulated	Homo sapiens	12-15
16509823-2	2006	Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF.	Oxygen	6-12	egl-9 family hypoxia inducible factor 1	Homo sapiens	87-91
16843087-9	2006	Similarly, vasopressin plus estrogen leads to cerebral vasoconstriction, resulting in a decrement of brain oxygen utilization and cerebral blood flow.	Oxygen	107-113	arginine vasopressin	Homo sapiens	11-22
16910783-0	2006	The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.	Oxygen	83-89	nitric oxide synthase 2	Homo sapiens	33-54
16814742-6	2006	Some flexibility of the myoglobin is required for these reactions to occur; a nucleophile is required near the chromophores for photoreduction (Krasnovskii reaction), and oxygen for photooxidation.	Oxygen	171-177	myoglobin	Equus caballus	24-33
16611863-6	2006	Expression of HIF1A and VHL was high at 7-9 wk of gestation, when oxygen tension is low, and decreased when placental oxygen tension increases (10-12 wk of gestation).	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
16611863-6	2006	Expression of HIF1A and VHL was high at 7-9 wk of gestation, when oxygen tension is low, and decreased when placental oxygen tension increases (10-12 wk of gestation).	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
16836698-6	2006	Peak oxygen consumption in the study population was 2.42 (+/-0.74) l min(-1) and subjects achieved 101 +/- 7% of this value during the measurement of .	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	69-75
16702992-12	2006	Chol-but SLN inhibited O2-* production and myeloperoxidase release by PMNs evoked by FMLP, in a dose-dependent, but not time-dependent, manner and were more active than sodium butyrate.	Oxygen	23-25	formyl peptide receptor 1	Homo sapiens	85-89
16842205-1	2006	Hypoxia inducible factor-1 (HIF-1) is a central component of the oxygen sensing system that coordinates cellular responses to conditions of decreased oxygen availability.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16842205-1	2006	Hypoxia inducible factor-1 (HIF-1) is a central component of the oxygen sensing system that coordinates cellular responses to conditions of decreased oxygen availability.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16842205-1	2006	Hypoxia inducible factor-1 (HIF-1) is a central component of the oxygen sensing system that coordinates cellular responses to conditions of decreased oxygen availability.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16842205-1	2006	Hypoxia inducible factor-1 (HIF-1) is a central component of the oxygen sensing system that coordinates cellular responses to conditions of decreased oxygen availability.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16814724-2	2006	Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.	Oxygen	33-39	tumor protein p53	Homo sapiens	8-11
16809770-4	2006	These findings imply that HIF-1 and AMPK are components of a concerted cellular response to maintain energy homeostasis in low-oxygen or ischemic-tissue microenvironments.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
16611863-10	2006	EGLN1, EGLN2, and EGLN3 were also temporally expressed in an oxygen-dependent fashion, with greatest mRNA expression at 10-12 wk of gestation.	Oxygen	61-67	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-5
16774642-3	2006	We propose that the enzyme is a member of the DHODH family 2, which comprises mitochondrially bound enzymes, with quinone as the direct electron acceptor and oxygen as the final electron acceptor.	Oxygen	158-164	dihydroorotate dehydrogenase (quinone)	Homo sapiens	46-51
16137743-14	2006	(b) All oxygen consuming cells have a built-in mechanism, the transcription factor HIF-1, the discovery of which has led to the delineation of oxygen-regulated gene expression.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-88
16830075-6	2006	A negative correlation (p &lt; 0.01) between IL-6, IL-8, and mixed venous oxygen saturation suggested compromised cardiopulmonary function.	Oxygen	74-80	interleukin 6	Homo sapiens	45-49
16889436-11	2006	JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.	Oxygen	153-159	mitogen-activated protein kinase 8	Homo sapiens	0-4
16137743-14	2006	(b) All oxygen consuming cells have a built-in mechanism, the transcription factor HIF-1, the discovery of which has led to the delineation of oxygen-regulated gene expression.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-88
16137743-16	2006	HIF-1alpha, which is a part of HIF-1, has come to be known as master regulator for oxygen homeostasis, and is precisely regulated by the cellular oxygen concentration.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16137743-16	2006	HIF-1alpha, which is a part of HIF-1, has come to be known as master regulator for oxygen homeostasis, and is precisely regulated by the cellular oxygen concentration.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16137743-16	2006	HIF-1alpha, which is a part of HIF-1, has come to be known as master regulator for oxygen homeostasis, and is precisely regulated by the cellular oxygen concentration.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16137743-16	2006	HIF-1alpha, which is a part of HIF-1, has come to be known as master regulator for oxygen homeostasis, and is precisely regulated by the cellular oxygen concentration.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16786114-14	2006	We conclude that HRE is a promising regulator for h-VEGF(165) gene expression following the changes of oxygen environment.	Oxygen	103-109	vascular endothelial growth factor A	Homo sapiens	52-56
16678800-3	2006	Recently, we demonstrated that AMP-activated protein kinase (AMPK), which acts as an energy sensor, providing metabolic adaptation effects under ATP-deprived conditions, is critical for the expression of VEGF under oxygen- and glucose-deprived conditions.	Oxygen	215-221	vascular endothelial growth factor A	Homo sapiens	204-208
16782814-0	2006	Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).	Oxygen	9-15	egl-9 family hypoxia inducible factor 1	Homo sapiens	91-95
16786114-15	2006	HRE can induce the expression of h-VEGF(165) gene after hypoxia, but in normal oxygen condition, the expression of h-VEGF(165) was inhibited.	Oxygen	79-85	vascular endothelial growth factor A	Homo sapiens	117-121
16565084-2	2006	These oxygen-sensitive modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family (PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of involvement of these and other enzymes of the same family in directing the global changes in gene expression that are induced by hypoxia.	Oxygen	6-12	egl-9 family hypoxia inducible factor 1	Homo sapiens	117-121
16523522-0	2006	The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells.	Oxygen	24-30	erythropoietin	Homo sapiens	100-114
16732655-9	2006	The aggregation mechanism is, therefore, believed to be due to hydrogen-bonding between the hydrogens of the carboxylic acid groups and the ether oxygens present on the surface of the PEO-functionalized particles.	Oxygen	146-153	twinkle mtDNA helicase	Homo sapiens	184-187
16854301-12	2006	The plasma ET-1 level showed significantly lower during APSSV than that before and during oxygen treatment (P &lt; 0.05), but no significant difference between the levels before and during oxygen treatment (P &gt; 0.05).	Oxygen	90-96	endothelin 1	Homo sapiens	11-15
16735674-7	2006	Depressed mitochondrial reactive oxygen species (ROS) production caused normoxic activation of hypoxia inducible factor (HIF-1alpha), which then inhibited expression of oxygen-sensitive, voltage-gated K+ channels (eg, Kv1.5).	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-131
16740701-2	2006	Two transcription factors [hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha] are dramatically induced in hypoxic areas and regulate the expression of genes necessary for tumor adaptation to the conditions of low oxygen; however, the relative contribution of these factors is controversial.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-58
16740701-2	2006	Two transcription factors [hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha] are dramatically induced in hypoxic areas and regulate the expression of genes necessary for tumor adaptation to the conditions of low oxygen; however, the relative contribution of these factors is controversial.	Oxygen	223-229	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
16713317-2	2006	This is accomplished through activation of RBC Na+/H+ exchange (beta-NHE), ultimately minimizing impairment to oxygen transport.	Oxygen	111-117	Na(+)/H(+) exchanger beta	Oncorhynchus mykiss	64-72
16775626-4	2006	HIF-3alpha was strongly induced by hypoxia (1% O2) both at the level of protein and mRNA due to an increase in protein stability and transcriptional activation, whereas HIF-1alpha protein and mRNA levels enhanced transiently and then decreased because of a reduction in its mRNA stability in A549 cells, as measured on mRNA and protein levels.	Oxygen	47-49	hypoxia inducible factor 3 subunit alpha	Homo sapiens	0-10
16651461-3	2006	Hypoxia (1% O2) increased both eNOS expression and NO production, peaking at 24 hours, in bovine aortic endothelial cells, and these increases were accompanied by increases in pCREB.	Oxygen	12-14	nitric oxide synthase 3	Bos taurus	31-35
16753841-0	2006	Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
16753841-0	2006	Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
16753841-4	2006	Here, we propose a hypothesis that peroxynitrite, formed in the cells upon exposure to NO under low oxygen availability, serves as an alternative donor of oxygen for activated PHDs so they can perform HIF-1alpha proline hydroxylation to de-accumulate the protein.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-211
16618841-8	2006	The renal BOLD response to angiotensin II appeared with short onset latency (as early as 10 seconds after peripheral intravenous angiotensin II bolus administration) suggesting that this response is a consequence of altered perfusion rather than increased renal oxygen consumption.	Oxygen	262-268	angiotensinogen	Homo sapiens	27-41
16845226-1	2006	The aim of this study was to examine the relationship between the content of various types of myosin heavy chain isoforms (MyHC) in the vastus lateralis muscle and pulmonary oxygen uptake during moderate power output incremental exercise, performed at low and at high pedalling rates.	Oxygen	174-180	myosin heavy chain 6	Homo sapiens	123-127
16388929-1	2006	The present study was aimed to speculate whether the up-regulation of VEGF in oral squamous cell carcinoma (OSCC) is associated with oxygen levels, tumor angiogenesis and severity of disease.	Oxygen	133-139	vascular endothelial growth factor A	Homo sapiens	70-74
16388929-2	2006	Under different oxygen levels, VEGF protein production in two oral cancer cell lines was quantitatively documented by using ELISA kit.	Oxygen	16-22	vascular endothelial growth factor A	Homo sapiens	31-35
16388929-4	2006	VEGF production was continuously elevated in supernatants from both cell lines in respond to the drop of oxygen levels.	Oxygen	105-111	vascular endothelial growth factor A	Homo sapiens	0-4
16388929-5	2006	When oxygen level decreased to 1%, there was a 2.1-fold and nearly a 2.9-fold elevation of VEGF production in TSCCa and GNM cell line, respectively.	Oxygen	5-11	vascular endothelial growth factor A	Homo sapiens	91-95
16545962-10	2006	In the active structures, S20 interacts with the gamma-P oxygen in Rab11b-GppNHp but does not in Rab11a-GppNHp and the Q70 side chain is found in different positions.	Oxygen	57-63	RAB11B, member RAS oncogene family	Homo sapiens	67-73
16845226-7	2006	We have found that during incremental exercise at the power output between 30-120 W, performed at 60 rev.min(-1), oxygen uptake in the group H was significantly greater than in the group L (ANCOVA, p=0.003, upward shift of the intercept in VO2/power output relationship).	Oxygen	114-120	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
16845226-8	2006	During cycling at the same power output but at 120 rev.min(-1), the oxygen uptake was also higher in the group H, when compared to the group L (i.e. upward shift of the intercept in VO2/power output relationship, ANCOVA, p=0.002).	Oxygen	68-74	CD59 molecule (CD59 blood group)	Homo sapiens	55-61
16845226-9	2006	Moreover, the increase in pedalling rate from 60 to 120 rev.min(-1) was accompanied by a significantly higher increase of oxygen cost of cycling and by a significantly higher plasma lactate concentration in subjects from group H. We concluded that the muscle mechanical efficiency, expressed by the VO2/PO ratio, during cycling in the range of power outputs 30-120 W, performed at 60 as well as 120 rev.min(-1), is significantly lower in the individuals with the highest content of MyHC II, when compared to the individuals with the lowest content of MyHC II in the vastus lateralis.	Oxygen	122-128	CD59 molecule (CD59 blood group)	Homo sapiens	60-66
16621843-1	2006	The cytochrome c550-deficient mutant (psbV-disruptant) of Synechocystis requires a high concentration of Cl(-) in the culture medium to support photosynthetic oxygen evolution.	Oxygen	159-165	cytochrome c, somatic	Homo sapiens	4-16
16738327-1	2006	The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that mediates adaptive cellular responses to decreased oxygen availability (hypoxia).	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-36
16738327-1	2006	The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that mediates adaptive cellular responses to decreased oxygen availability (hypoxia).	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-49
16407821-6	2006	Interestingly, there was pericellular hypoxia in the vicinity of NIH3T3 fibroblasts when co-cultured with "dense" epithelial cells, and the recovery of the partial pressure of oxygen level resulted in the reduction of enhanced COX-2 expression only in NIH3T3 fibroblasts co-cultured with "dense" Intestine-407 cells.	Oxygen	176-182	prostaglandin-endoperoxide synthase 2	Homo sapiens	227-232
16641218-1	2006	Animal studies have shown that induction of cytochrome P450 (CYP) in the lung by oxygen exposure may result in the release of free radical oxidants and arachidonic acid metabolites, which can cause lung injury that is reduced by treatment with cimetidine, a CYP inhibitor.	Oxygen	81-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59
16641218-1	2006	Animal studies have shown that induction of cytochrome P450 (CYP) in the lung by oxygen exposure may result in the release of free radical oxidants and arachidonic acid metabolites, which can cause lung injury that is reduced by treatment with cimetidine, a CYP inhibitor.	Oxygen	81-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-64
16641218-1	2006	Animal studies have shown that induction of cytochrome P450 (CYP) in the lung by oxygen exposure may result in the release of free radical oxidants and arachidonic acid metabolites, which can cause lung injury that is reduced by treatment with cimetidine, a CYP inhibitor.	Oxygen	81-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	258-261
16491397-4	2006	In this study, we tested the hypothesis that the reported shift in MyHC composition to slower isoforms in CK-deficient muscle leads to a decrease in oxygen cost of twitch performance.	Oxygen	149-155	myosin heavy chain, cardiac muscle complex	Mus musculus	67-71
16719463-2	2006	The peroxo complex (eta(2)-O(2))PdL(2) (L = PPh(3)), generated in the reaction of dioxygen with the Pd(0) catalyst, was found to play a crucial role.	Oxygen	82-90	caveolin 1	Homo sapiens	44-50
16484344-8	2006	Furthermore, NPC2 protein upregulates hypoxia inducible factor 1-alpha protein level at 7% O(2), but not at 20% O(2).	Oxygen	91-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-70
16724053-2	2006	The mTOR protein kinase has emerged as a critical growth-control node, receiving stimulatory signals from Ras and phosphatidylinositol-3-OH kinase (PI(3)K) downstream from growth factors, as well as nutrient inputs in the form of amino-acid, glucose and oxygen availability.	Oxygen	254-260	mechanistic target of rapamycin kinase	Homo sapiens	4-8
16681377-1	2006	(4-Hydroxyphenyl)pyruvate dioxygenase (HPPD) incorporates both atoms of molecular oxygen into 4-hydroxyphenylpyruvate (HPP) to form homogentisate (HG).	Oxygen	28-34	4-hydroxyphenylpyruvate dioxygenase	Arabidopsis thaliana	39-43
16407835-3	2006	A large number of disease-causing mutations in either the alpha or beta domain renders HIFalpha stable irrespective of oxygen tension, leading to the upregulation of numerous HIF-target genes, such as GLUT1 and VEGF.	Oxygen	119-125	vascular endothelial growth factor A	Homo sapiens	211-215
16514109-8	2006	The IL-6 response to exercise was attenuated during cycling with supplemental oxygen.	Oxygen	78-84	interleukin 6	Homo sapiens	4-8
16514109-11	2006	CONCLUSION: Short-term supplementary oxygen does not affect basal systemic inflammation and oxidative stress but prevents exercise-induced oxidative stress in normoxemic, muscle-wasted patients with COPD, and attenuates plasma IL-6 response.	Oxygen	37-43	interleukin 6	Homo sapiens	227-231
16709134-7	2006	Imidazolium cations are coordinated by both the anions and the oxygen atoms of PEO chains.	Oxygen	63-69	twinkle mtDNA helicase	Homo sapiens	79-82
16673038-8	2006	At sufficiently high concentration of PPh3, the oxygen atom transfer from 2 to PPh3 was followed by the formation of [Cu(PPh3)3I].	Oxygen	48-54	caveolin 1	Homo sapiens	38-42
16673038-8	2006	At sufficiently high concentration of PPh3, the oxygen atom transfer from 2 to PPh3 was followed by the formation of [Cu(PPh3)3I].	Oxygen	48-54	caveolin 1	Homo sapiens	79-83
16673038-8	2006	At sufficiently high concentration of PPh3, the oxygen atom transfer from 2 to PPh3 was followed by the formation of [Cu(PPh3)3I].	Oxygen	48-54	caveolin 1	Homo sapiens	79-83
16634644-1	2006	Specific substrate-induced structural changes in the heme pocket are proposed for human cytochrome P450 aromatase (P450arom) which undergoes three consecutive oxygen activation steps.	Oxygen	159-165	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	115-123
15967572-1	2006	Glioma cells produce vascular endothelial growth factor (VEGF) to induce vascularization and thereby supply the malignant tissue with oxygen and nutrients.	Oxygen	134-140	vascular endothelial growth factor A	Homo sapiens	21-55
15967572-1	2006	Glioma cells produce vascular endothelial growth factor (VEGF) to induce vascularization and thereby supply the malignant tissue with oxygen and nutrients.	Oxygen	134-140	vascular endothelial growth factor A	Homo sapiens	57-61
16827160-4	2006	The data demonstrated that, in all cell types assayed, either hypoxia or CoCl2 induced the main regulator of transcriptional responses to reduced oxygen tension, namely the hypoxia inducible factor-1alpha (HIF-1alpha), in a dose- and time-dependent manner.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-204
16339827-0	2006	DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption.	Oxygen	104-110	vascular endothelial growth factor A	Homo sapiens	53-57
16339827-1	2006	In its role as an endothelial cell proliferation and migration factor, vascular endothelial growth factor (VEGF) can affect peripheral circulation and therefore impact maximal oxygen consumption (Vo2 max).	Oxygen	176-182	vascular endothelial growth factor A	Homo sapiens	71-105
16339827-1	2006	In its role as an endothelial cell proliferation and migration factor, vascular endothelial growth factor (VEGF) can affect peripheral circulation and therefore impact maximal oxygen consumption (Vo2 max).	Oxygen	176-182	vascular endothelial growth factor A	Homo sapiens	107-111
16771675-5	2006	The CCS-dependent activation of SOD1 is dependent upon oxygen availability, suggesting that the cell only loads copper and activates this enzyme when O(2)-based oxidative stress is present.	Oxygen	55-61	superoxide dismutase 1	Homo sapiens	32-36
16771675-5	2006	The CCS-dependent activation of SOD1 is dependent upon oxygen availability, suggesting that the cell only loads copper and activates this enzyme when O(2)-based oxidative stress is present.	Oxygen	150-154	superoxide dismutase 1	Homo sapiens	32-36
16827160-4	2006	The data demonstrated that, in all cell types assayed, either hypoxia or CoCl2 induced the main regulator of transcriptional responses to reduced oxygen tension, namely the hypoxia inducible factor-1alpha (HIF-1alpha), in a dose- and time-dependent manner.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-216
17193962-5	2006	Low level of iron and significantly increased erythropoietin on R+0 are the testimony of intensive hemoglobin production and an adequate bone morrow response to the increased oxygen demand.	Oxygen	175-181	erythropoietin	Homo sapiens	46-60
16310922-1	2006	Cells exposed to low oxygen conditions respond by initiating defense mechanisms, including the stabilization of hypoxia-inducible factor (HIF) 1alpha, a transcription factor that upregulates genes such as those involved in angiogenesis and glycolysis, which also plays a pivotal role in the regulation of cellular utilization of oxygen and is an essential regulator of angiogenesis in solid tumor and ischemic disorders.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-149
16310922-1	2006	Cells exposed to low oxygen conditions respond by initiating defense mechanisms, including the stabilization of hypoxia-inducible factor (HIF) 1alpha, a transcription factor that upregulates genes such as those involved in angiogenesis and glycolysis, which also plays a pivotal role in the regulation of cellular utilization of oxygen and is an essential regulator of angiogenesis in solid tumor and ischemic disorders.	Oxygen	329-335	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-149
16310922-3	2006	In the present study we found that nitric oxide inhibits HIF-1alpha accumulation under low oxygen (1%) conditions.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
16473902-6	2006	This grabbing motion resulted in smooth and stepwise exchange in coordination partners of Ca2+ from water oxygen to atoms in the calmodulin loop.	Oxygen	106-112	calmodulin 1	Homo sapiens	129-139
16708536-9	2006	CONCLUSION: GPx-3 and GSH could constitute the most readily mobilizable antioxidants that would then contribute to the buffering against a sudden increase in the generation of radical oxygen species.	Oxygen	184-190	glutathione peroxidase 3	Homo sapiens	12-17
16687917-2	2006	As it is typically driven by elevated or inappropriately normal erythropoietin (Epo) levels, it has the potential to reveal the identities of proteins involved in the oxygen sensing pathway that regulates the transcription factor, Hypoxia Inducible Factor (HIF), and hence Epo production in humans.	Oxygen	167-173	erythropoietin	Homo sapiens	64-78
15830398-5	2006	(1) Increased reactive oxygen metabolites levels in ulcerative colitis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased malondialdehyde levels, (2) increased cytokines may be a possible cause of decreased paraoxonase 1 activity and (3) decreased serum paraoxonase 1 activity may be a part of an inflammatory response.	Oxygen	23-29	paraoxonase 1	Homo sapiens	166-179
15830398-5	2006	(1) Increased reactive oxygen metabolites levels in ulcerative colitis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased malondialdehyde levels, (2) increased cytokines may be a possible cause of decreased paraoxonase 1 activity and (3) decreased serum paraoxonase 1 activity may be a part of an inflammatory response.	Oxygen	23-29	paraoxonase 1	Homo sapiens	288-301
15830398-5	2006	(1) Increased reactive oxygen metabolites levels in ulcerative colitis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased malondialdehyde levels, (2) increased cytokines may be a possible cause of decreased paraoxonase 1 activity and (3) decreased serum paraoxonase 1 activity may be a part of an inflammatory response.	Oxygen	23-29	paraoxonase 1	Homo sapiens	288-301
16627974-1	2006	Hypoxia-inducible factor (HIF)-1alpha, a global regulator of oxygen homeostasis, plays a crucial role in tumor cell adaptation to the hypoxic microenvironment through transcriptional regulation of its target genes.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
16687917-2	2006	As it is typically driven by elevated or inappropriately normal erythropoietin (Epo) levels, it has the potential to reveal the identities of proteins involved in the oxygen sensing pathway that regulates the transcription factor, Hypoxia Inducible Factor (HIF), and hence Epo production in humans.	Oxygen	167-173	erythropoietin	Homo sapiens	80-83
16687917-2	2006	As it is typically driven by elevated or inappropriately normal erythropoietin (Epo) levels, it has the potential to reveal the identities of proteins involved in the oxygen sensing pathway that regulates the transcription factor, Hypoxia Inducible Factor (HIF), and hence Epo production in humans.	Oxygen	167-173	erythropoietin	Homo sapiens	273-276
16373444-10	2006	Insulin resistance was reversed by exercise (40.1 +/- 7.7 vs. 27.6 +/- 5.6 units, P &lt; 0.01) and correlated with changes in VF (r = 0.66, P &lt; 0.01) and maximal oxygen consumption (r = -0.48, P &lt; 0.05) but not adipocytokines.	Oxygen	165-171	insulin	Homo sapiens	0-7
16455829-8	2006	C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance.	Oxygen	117-123	C-reactive protein	Homo sapiens	0-18
16675839-3	2006	Here I propose a model in which an alteration in oxygen metabolism is the key cellular event involved in HIF-1 activation under hypoxic and nonhypoxic conditions.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-110
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Oxygen	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16779519-4	2006	Cells were then exposed to control medium (M199/1% fetal bovine serum/2% antibiotic-antimycotic) or control medium with 100 ng/mL insulin in oxygen concentrations of 17% (normoxia), 5%, and 1%.	Oxygen	141-147	insulin	Homo sapiens	130-137
16803994-3	2006	We report that the exposure of human neuroblastoma cells to hyperoxia (40% vs. 8% ambient oxygen) induced the accumulation of large (over 1 microM) Abeta-containing lysosomes, which were not typical of control cells, showing a distinct localization of Abeta and lysosomal markers.	Oxygen	90-96	amyloid beta precursor protein	Homo sapiens	148-153
16614266-3	2006	Radionuclide myocardial perfusion defects, coronary sinus oxygen saturation abnormalities and pH changes, myocardial lactate production and stress-induced alterations of cardiac high energy phosphate have been reported in CSX patients, suggesting an ischaemic origin for their symptoms.	Oxygen	58-64	NK2 homeobox 5	Homo sapiens	222-225
16677307-5	2006	Under oxygen-restricted conditions, FNR positively controlled the transcription of nine transcriptional units, the most upregulated of which were the two operons NMB0388-galM and mapA-pgmbeta implicated in sugar metabolism and fermentation.	Oxygen	6-12	galactose mutarotase	Homo sapiens	170-174
16408279-10	2006	These results indicate that normoxic stabilization of HIF-1alpha is a metabolic adaptation of nucleus pulposus cells to a unique oxygen-limited microenvironment.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
16677307-5	2006	Under oxygen-restricted conditions, FNR positively controlled the transcription of nine transcriptional units, the most upregulated of which were the two operons NMB0388-galM and mapA-pgmbeta implicated in sugar metabolism and fermentation.	Oxygen	6-12	leucine rich repeat containing 25	Homo sapiens	179-183
16331674-6	2006	Hypoxia induced increased total protein levels in hMSC throughout the culture period, as well as significantly different fibronectin expression patterns suggesting that oxygen levels can significantly affect tissue-development patterns.	Oxygen	169-175	fibronectin 1	Homo sapiens	121-132
16598858-3	2006	NEM-treated cytochrome c has lower reducibility and lower function to support mitochondrial oxygen consumption.	Oxygen	92-98	cytochrome c, somatic	Homo sapiens	12-24
16689381-3	2006	In addition, ischemia will also be controlled by decreasing oxygen demand related to BP and HR, and with increasing oxygen supply by increased ECNOS gene expression, collateral formation and regression of coronary stenosis.	Oxygen	116-122	nitric oxide synthase 3	Homo sapiens	143-148
16500018-16	2006	The use of 100% oxygen was associated with increased level of NSE at 24h in patients not treated with therapeutic hypothermia.	Oxygen	16-22	enolase 2	Homo sapiens	62-65
16774156-3	2006	We thus examined the relationship between serum C-reactive protein levels and nocturnal arterial oxygen desaturation, stratified by category of body mass index (BMI).	Oxygen	97-103	C-reactive protein	Homo sapiens	48-66
16516853-1	2006	The hypoxia-inducible factor (HIF) 1alpha is a key regulator of the cellular response to oxygen deprivation.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-41
16631533-2	2006	Conditions of decreased oxygen availability provoke accumulation and activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-109
16631533-2	2006	Conditions of decreased oxygen availability provoke accumulation and activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-116
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16605242-0	2006	Fluorophore-assisted light inactivation of calmodulin involves singlet-oxygen mediated cross-linking and methionine oxidation.	Oxygen	71-77	calmodulin 1	Homo sapiens	43-53
16585600-12	2006	Although CpG DNA alone had no effect, IFN-gamma plus CpG enhanced NO and reactive oxygen metabolite release compared with IFN-gamma treatment alone.	Oxygen	82-88	interferon gamma	Homo sapiens	38-47
16598858-6	2006	SNO-cytochrome c has lower reducibility and function to support mitochondrial oxygen consumption, similar to NEM-treated cytochrome c.	Oxygen	78-84	cytochrome c, somatic	Homo sapiens	4-16
16599438-6	2006	The topological analysis of the distribution of the charge density (AIM theory) confirmed the existence of the hydrogen bond in I-1, I-2 complexes and indicated weak interaction between the oxygen atom of CH(3)OH and three fluorine atoms of CF(4) in the I-3 complex.	Oxygen	190-196	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	128-131
16600877-3	2006	Unlike the chromodomain that recognizes the methylated H3-K4 through a hydrophobic cage, the specificity of WDR5 for methylated H3-K4 is conferred by the nonconventional hydrogen bonds between the two zeta-methyl groups of the dimethylated Lys4 and the carboxylate oxygen of Glu322 in WDR5.	Oxygen	265-271	WD repeat domain 5	Homo sapiens	108-112
16584176-9	2006	These results suggest that ADX functions as an effector for the oxygen transfer reaction in addition to being an electron donor for CYP27B1.	Oxygen	64-70	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	132-139
16571065-0	2006	Perfluorobutane sulfonic acid hydration and interactions with O2 adsorbed on Pt3.	Oxygen	62-64	zinc finger protein 135	Homo sapiens	77-80
16598262-3	2006	Cytochrome c oxidase is a key component of the respiratory chain, which harnesses dioxygen as a sink for electrons and links O2 reduction to proton pumping.	Oxygen	82-90	cytochrome c, somatic	Homo sapiens	0-12
16585616-7	2006	It should be noted that the average value of dissolved oxygen was 3.4 mg L-1 with an air supply of 15 L min-1, and there was no indication of oxygen limitation.	Oxygen	55-61	CD59 molecule (CD59 blood group)	Homo sapiens	104-109
16598262-3	2006	Cytochrome c oxidase is a key component of the respiratory chain, which harnesses dioxygen as a sink for electrons and links O2 reduction to proton pumping.	Oxygen	125-127	cytochrome c, somatic	Homo sapiens	0-12
16598262-4	2006	Electrons from cytochrome c are transferred sequentially to the O2 reduction site of cytochrome c oxidase via two other metal centres, Cu(A) and haem a, and this is coupled to vectorial proton transfer across the membrane by a hitherto unknown mechanism.	Oxygen	64-66	cytochrome c, somatic	Homo sapiens	15-27
16598262-4	2006	Electrons from cytochrome c are transferred sequentially to the O2 reduction site of cytochrome c oxidase via two other metal centres, Cu(A) and haem a, and this is coupled to vectorial proton transfer across the membrane by a hitherto unknown mechanism.	Oxygen	64-66	cytochrome c, somatic	Homo sapiens	85-97
16434697-3	2006	We show that hypoxia (&lt;0.3% O2 for 48 h) reduced the output of TNF-alpha-induced proMMP-9 by threefold (P &lt; 0.01) in the U937 monocytic cell line and in primary human monocytes.	Oxygen	31-33	tumor necrosis factor	Homo sapiens	66-75
16585195-0	2006	The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-62
16585195-1	2006	The function of the hypoxia-inducible factor-1 (HIF-1), the key transcription factor involved in cellular adaptation to hypoxia, is restricted to low oxygen tension (pO(2)).	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-46
16585195-1	2006	The function of the hypoxia-inducible factor-1 (HIF-1), the key transcription factor involved in cellular adaptation to hypoxia, is restricted to low oxygen tension (pO(2)).	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-53
16384869-12	2006	The expression pattern of EG-VEGF, its regulation by oxygen tension, and its complementary localization to that of VEGF suggest that this new factor might also be deregulated in preeclampsia.	Oxygen	53-59	vascular endothelial growth factor A	Homo sapiens	29-33
16516296-0	2006	Cobalt(IV) corroles as catalysts for the electroreduction of O2: reactions of heterobimetallic dyads containing a face-to-face linked Fe(III) or Mn(III) porphyrin.	Oxygen	61-63	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	137-140
16516296-0	2006	Cobalt(IV) corroles as catalysts for the electroreduction of O2: reactions of heterobimetallic dyads containing a face-to-face linked Fe(III) or Mn(III) porphyrin.	Oxygen	61-63	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-151
16551791-1	2006	Recombinant human growth hormone (rhGH) therapy in Prader-Willi syndrome (PWS) causes increased basal metabolic rate and oxygen consumption, and hence increased ventilatory load.	Oxygen	121-127	growth hormone 1	Homo sapiens	18-32
16304044-2	2006	In mammalian cells, the transcriptional response to oxygen deprivation is largely mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer composed of HIF-1alpha and HIF-1beta subunits.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-120
16304044-2	2006	In mammalian cells, the transcriptional response to oxygen deprivation is largely mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer composed of HIF-1alpha and HIF-1beta subunits.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-127
16304044-7	2006	Neutralizing antibodies to bFGF, but not IGF-1, VEGF, or PDGF-BB, blocked survival and sprouting of HUVECs under hypoxic conditions, suggesting the existence of an autocrine loop induced by low oxygen levels.	Oxygen	194-200	fibroblast growth factor 2	Homo sapiens	27-31
16094314-1	2006	Superoxide-dismutases (SOD) catalyze O2- conversion to hydrogen peroxide (H2O2) and with other antioxidant enzymes and low molecular weight antioxidants (LMWA) constitute endogenous defense mechanisms.	Oxygen	37-39	superoxide dismutase 1, soluble	Mus musculus	23-26
16427074-3	2006	Evidence is accumulating that this molecular O2 sensor is, surprisingly, a class of soluble guanylyl cyclase (sGC) known as atypical sGCs.	Oxygen	45-47	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	84-108
16427074-3	2006	Evidence is accumulating that this molecular O2 sensor is, surprisingly, a class of soluble guanylyl cyclase (sGC) known as atypical sGCs.	Oxygen	45-47	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	110-113
16009421-1	2006	Nitric oxide is produced enzymatically by the nitric oxide synthase (NOS), which converts L-arginine in the presence of oxygen to L-citrulline and NO.	Oxygen	120-126	nitric oxide synthase 2	Homo sapiens	46-67
16482104-6	2006	By epitope-mapping, we show that all five antibody fragments bind within the functionally important oxygen-dependent degradation domain of the HIF-1alpha protein.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-153
16581766-5	2006	Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia.	Oxygen	94-98	NK2 homeobox 1	Homo sapiens	144-149
16581766-5	2006	Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia.	Oxygen	94-98	CREB binding protein	Homo sapiens	156-159
16628086-2	2006	METHODS: BxPc-3 cells transfected with antisense HIF-1alpha plasmid were exposed to 0.5% O2 for 4 hours.	Oxygen	89-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
16549519-1	2006	We tested the hypothesis that inducible isoform of nitric oxide synthase (iNOS)-derived nitric oxide (NO) inhibits oxygen consumption (VO2) in human intestine resected for necrotizing enterocolitis (NEC).	Oxygen	115-121	nitric oxide synthase 2	Homo sapiens	74-78
16009423-1	2006	Insulin-dependent diabetes mellitus (Type I) is associated with disregulation of the glucose and oxygen metabolic pathways during pregnancy, both of which affect placental villous development.	Oxygen	97-103	insulin	Homo sapiens	0-7
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16171982-3	2006	In this work, we show that the thi4 strain presents significant induction of petites and reduced oxygen consumption when grown at 37 degrees C, a condition that induces high levels of reactive oxygen species in yeast.	Oxygen	97-103	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	31-35
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	placental growth factor	Homo sapiens	132-154
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	vascular endothelial growth factor A	Homo sapiens	29-65
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	vascular endothelial growth factor A	Homo sapiens	67-73
16407229-1	2006	Hypoxia-inducible factor-1 (HIF-1), a transcriptional complex composed of an oxygen-sensitive alpha- and a beta-subunit, plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16407229-1	2006	Hypoxia-inducible factor-1 (HIF-1), a transcriptional complex composed of an oxygen-sensitive alpha- and a beta-subunit, plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16407229-1	2006	Hypoxia-inducible factor-1 (HIF-1), a transcriptional complex composed of an oxygen-sensitive alpha- and a beta-subunit, plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	placental growth factor	Homo sapiens	156-160
16407229-1	2006	Hypoxia-inducible factor-1 (HIF-1), a transcriptional complex composed of an oxygen-sensitive alpha- and a beta-subunit, plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16480683-2	2006	The reaction of cytochrome c with GSH involves radical oxygen species and exhibits significant complexity.	Oxygen	55-61	cytochrome c, somatic	Homo sapiens	16-28
16553373-4	2006	Here, by using density functional theory calculations, we modeled the reaction route from the reaction components to the high-spin metal-oxide intermediate in the activation of oxygen molecule by 2OG-dependent enzymes for three metal ions Fe(II), Ni(II), and Co(II) in the active site.	Oxygen	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
16542075-14	2006	The oxygen atom isotope exchange reaction involving ArO and ArO2 van der Waals complexes is also investigated; the weak binding of O or O2 to Ar has only a small effect.	Oxygen	4-10	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	52-55
16526629-3	2006	Results indicate an increase in activity as the oxygen-to-sulfur ratio increases (SO2 &gt; SCO &gt; CS2) with products ranging from association to break down of the met-car cluster.	Oxygen	48-54	chorionic somatomammotropin hormone 2	Homo sapiens	100-103
16227345-4	2006	The present study hypothesized that an NAD(P)H oxidase on the sarcoplasmic reticulum (SR) in coronary artery smooth muscle (CASM) regulates SR ryanodine receptor (RyR) activity by producing O2-* locally.	Oxygen	190-192	ryanodine receptor 1	Homo sapiens	163-166
16407262-3	2006	Here we describe results that identified oxygen as the terminal electron acceptor for plant sulfite oxidase and hydrogen peroxide as the product of this reaction in addition to sulfate.	Oxygen	41-47	sulfite oxidase	Arabidopsis thaliana	92-107
16227345-6	2006	Fluorescent spectrometric analysis demonstrated that incubation of SR with NADH time dependently produced O2-*, which could be substantially blocked by the specific NAD(P)H oxidase inhibitors diphenylene iodonium and apocynin and by SOD or its mimetic tiron.	Oxygen	106-108	superoxide dismutase 1	Homo sapiens	233-236
16227345-9	2006	These results suggest that a local NAD(P)H oxidase system on SR from CASM regulates RyR/Ca2+ channel activity and Ca2+ release from SR by producing O2-*.	Oxygen	148-150	ryanodine receptor 1	Homo sapiens	84-87
16677093-0	2006	Regulation by the cAMP cascade of oxygen free radical balance in mammalian cells.	Oxygen	34-40	cathelicidin antimicrobial peptide	Homo sapiens	18-22
16677093-1	2006	A study is presented of the effect of the cAMP cascade on oxygen metabolism in mammalian cell cultures.	Oxygen	58-64	cathelicidin antimicrobial peptide	Homo sapiens	42-46
16517406-0	2006	HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	30-32	paraoxonase 1	Homo sapiens	14-18
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	30-32	paraoxonase 1	Homo sapiens	90-94
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	30-32	paraoxonase 1	Homo sapiens	90-94
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	35-41	paraoxonase 1	Homo sapiens	14-18
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	35-41	paraoxonase 1	Homo sapiens	90-94
16026789-9	2006	Exposition of PON1 to *OH and O2*- oxygen free radicals induced a significant decrease in PON1 p.ase activity as well as a reduction in the number of PON1"s free sulfhydryl groups.	Oxygen	35-41	paraoxonase 1	Homo sapiens	90-94
16337793-2	2006	For the development of imaging agents, we have synthesized novel derivatives of recently reported diphenylsulfide SERT ligands, in which the sulfur atom linking the two phenyl rings was replaced by an oxygen, sulfinyl, sulfonyl, amino or carbon group.	Oxygen	201-207	solute carrier family 6 member 4	Homo sapiens	114-118
16517406-1	2006	The HIF-1 transcription factor drives hypoxic gene expression changes that are thought to be adaptive for cells exposed to a reduced-oxygen environment.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
16517406-4	2006	However, we find that while HIF-1 stimulates glycolysis, it also actively represses mitochondrial function and oxygen consumption by inducing pyruvate dehydrogenase kinase 1 (PDK1).	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16505665-8	2006	However, intensive insulin therapy was associated with increased incidence of microdialysis markers of cellular distress, namely elevated glutamate (38+/-37% vs. 10+/-17%, p&lt;.01), elevated lactate/pyruvate ratio (38+/-37% vs. 19+/-26%, p&lt;.03) and low glucose (26+/-17% vs. 11+/-15%, p&lt;.05, and increased global oxygen extraction fraction.	Oxygen	320-326	insulin	Homo sapiens	19-26
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Oxygen	308-314	signal transducer and activator of transcription 3	Homo sapiens	28-33
16505017-13	2006	CONCLUSIONS: A constitutively expressed NADPH oxidase complex that includes NOX4 is a source of O2-* produced by rabbit corneal epithelial and stromal cells.	Oxygen	96-98	NADPH oxidase 4	Oryctolagus cuniculus	76-80
16526637-1	2006	The heterogeneous reaction of liquid oleic acid aerosol particles with NO3 radicals in the presence of NO2, N2O5, and O2 was investigated in an environmental chamber using a combination of on-line and off-line mass spectrometric techniques.	Oxygen	104-106	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
16526637-3	2006	The key intermediate in the reaction is the nitrooxyalkylperoxy radical, which is formed by the addition of NO3 to the carbon-carbon double bond and subsequent addition of O2.	Oxygen	172-174	NBL1, DAN family BMP antagonist	Homo sapiens	108-111
16505036-0	2006	Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons.	Oxygen	28-34	cytoglobin	Homo sapiens	16-26
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	cytoglobin	Homo sapiens	135-145
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	cytoglobin	Homo sapiens	147-151
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	cytoglobin	Homo sapiens	208-212
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Oxygen	308-314	signal transducer and activator of transcription 3	Homo sapiens	121-126
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Oxygen	308-314	signal transducer and activator of transcription 3	Homo sapiens	121-126
16337823-2	2006	The aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (EPO), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF1A) mRNAs, and to investigate the postmortem stability of these mRNA transcripts in forensic autopsy materials.	Oxygen	69-75	erythropoietin	Homo sapiens	104-118
16337823-2	2006	The aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (EPO), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF1A) mRNAs, and to investigate the postmortem stability of these mRNA transcripts in forensic autopsy materials.	Oxygen	69-75	erythropoietin	Homo sapiens	120-123
16540826-6	2006	RESULTS: Peak oxygen uptake increased significantly in the diet and exercise group (mean +/- SD: 32 +/- 5 mL x kg(-1) x min(-1) before; 40 +/- 8 mL x kg(-1) x min(-1) after) but not in the diet only group (34 +/- 7 mL x kg(-1) x min(-1) before; 35 +/- 8 mL x kg(-1) x min(-1) after).	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	120-126
16337823-2	2006	The aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (EPO), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF1A) mRNAs, and to investigate the postmortem stability of these mRNA transcripts in forensic autopsy materials.	Oxygen	69-75	vascular endothelial growth factor A	Homo sapiens	126-160
16337823-2	2006	The aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (EPO), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF1A) mRNAs, and to investigate the postmortem stability of these mRNA transcripts in forensic autopsy materials.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-204
16337823-2	2006	The aim of the present study was to establish quantitative assays of oxygen-regulated factors including erythropoietin (EPO), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF1A) mRNAs, and to investigate the postmortem stability of these mRNA transcripts in forensic autopsy materials.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-211
16417408-2	2006	A transcription factor, hypoxia-inducible factor (HIF), plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
16438547-3	2006	The MP2/6-31G(d) geometries and a natural population analysis of natural lone-pair orbitals on the donor atoms support the mechanism and reveal that oxygen and nitrogen donor groups are more stabilizing than sulfur.	Oxygen	149-155	major intrinsic protein of lens fiber	Homo sapiens	4-9
16736613-8	2006	Associated with p53, HIF-1alpha may induce apoptosis, which decreases oxygen consumption and lightens hypoxia in the scar maturation.	Oxygen	70-76	tumor protein p53	Homo sapiens	16-19
16736613-8	2006	Associated with p53, HIF-1alpha may induce apoptosis, which decreases oxygen consumption and lightens hypoxia in the scar maturation.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16471857-11	2006	A slightly activated rearrangement to a symmetric triangular Au(3) intermediate with two equivalent Au-H bonds, addition of O(2) into the Au-H bond, and rotation reforms the hydroperoxy intermediate in the main cycle.	Oxygen	124-128	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	138-142
16326710-13	2006	Isolated heart mitochondria from 5-day-old sod2 null animals respiring on the complex II substrate succinate exhibited statistically significant higher levels of mitochondrial O2* (157%, p &lt; 0.01) but significantly less H2O2 (33%, p &lt; 0.001) than wild type littermates.	Oxygen	176-178	superoxide dismutase 2, mitochondrial	Mus musculus	43-47
16677483-9	2006	Compared with the hypoxia group, the mPAP, the plasma levels of U-II, NO, and CNP, and the lung tissue homogenate levels of U-II and CNP in the oxygen treatment group [(31.4 +/- 2.0) mm Hg, (2.1 +/- 0.7) pg/ml, (14.8 +/- 1.7) micromol/L, (4.4 +/- 0.7) pg/ml; (3.5 +/- 0.8) pg/ml, (0.74 +/- 0.17) pg/ml, respectively] were significantly decreased (all P &lt; 0.01).	Oxygen	144-150	urotensin 2	Rattus norvegicus	124-128
16475826-10	2006	Oxidation of ferrous TyrH by molecular oxygen can be described as a single-step second-order reaction, with a rate constant of 210 mM(-)(1) s(-)(1).	Oxygen	39-45	tyrosine hydroxylase	Homo sapiens	21-25
16473674-1	2006	Cellular response to limiting oxygen levels is managed, in part, by the transcription factor hypoxia-inducible factor 1 (HIF-1), and the prolyl hydroxylase (PHD) family of oxygen-requiring enzymes.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-119
16473674-1	2006	Cellular response to limiting oxygen levels is managed, in part, by the transcription factor hypoxia-inducible factor 1 (HIF-1), and the prolyl hydroxylase (PHD) family of oxygen-requiring enzymes.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-126
16483933-8	2006	Together, eIF2alpha, eEF2, and mTOR inhibition represent important HIF-independent mechanisms of energy conservation that promote survival under low O2 conditions.	Oxygen	149-151	mechanistic target of rapamycin kinase	Homo sapiens	31-35
16489060-14	2006	CONCLUSIONS: Our results show that increased levels and nuclear translocation of the cellular oxygen sensor, PHD2, are associated with less differentiated and strongly proliferating tumors.	Oxygen	94-100	egl-9 family hypoxia inducible factor 1	Homo sapiens	109-113
16435846-0	2006	Phosphonation of arenes with dialkyl phosphites catalyzed by Mn(II)/Co(II)/O2 redox couple.	Oxygen	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
16155085-4	2006	In this study, we examined the effect of pharmacological inhibitors of these kinases on maximum tension generated by IPA from CH rats (10% O2 for 21 days) in response to ET-1.	Oxygen	139-141	endothelin 1	Rattus norvegicus	170-174
16143585-14	2006	We conclude that the normal function of eNOS becomes uncoupled after birth, leading to a developmental adaptation of the pulmonary vascular system to produce oxygen species other than NO.	Oxygen	158-164	nitric oxide synthase, endothelial	Ovis aries	40-44
16251495-10	2006	The reduction in the invasive capacity of EVT cultured at 3% oxygen appears to be mediated both by a general inhibition of the PLAU system and a decrease in the number of cells available to invade.	Oxygen	61-67	plasminogen activator, urokinase	Homo sapiens	127-131
16172163-7	2006	Also, enzymatic generation of O2-* by xanthine oxidase-lumazine and H2O2 by glucose oxidase-glucose increased occludin phosphorylation, implicating reactive oxygen species as modulators of the OxPAPC effects on occludin phosphorylation.	Oxygen	30-32	occludin	Bos taurus	110-118
16139409-2	2006	In the presence of oxygen and iron, proline residues in two degradation domains are modified by HIF-1-prolyl hydroxylases (PHDs), resulting in ubiquitination and degradation of HIF-1alpha.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-187
16139409-3	2006	Since both molecular oxygen and iron are elements required for this hydroxylation process, HIF-1alpha might be unmodified and stable in conditions lacking oxygen or iron.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16139409-3	2006	Since both molecular oxygen and iron are elements required for this hydroxylation process, HIF-1alpha might be unmodified and stable in conditions lacking oxygen or iron.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16139409-10	2006	The further mutational analysis demonstrated that the ARD1-acetylated motif near the C-terminal degradation domain (CDD) modulates the oxygen-dependent regulation of HIF-1alpha.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
16139409-11	2006	The oxygen-dependent HIF-1alpha regulation requiring both proline hydroxylation and lysine acetylation may be more complicated than the iron-dependent regulation requiring only proline hydroxylation.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16099461-1	2006	We have reported that, in rats, hypoxia (10.8% O2) stimulates prolactin (PRL) release from the pituitary.	Oxygen	47-49	prolactin	Rattus norvegicus	62-71
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	epidermal growth factor receptor	Homo sapiens	26-30
16420471-5	2006	The data suggest an important role of the glob1 protein in Drosophila, which may be the control of oxygen flow from the tracheal system.	Oxygen	99-105	globin 1	Drosophila melanogaster	42-47
16452213-10	2006	Therefore, failure to inhibit mTOR under oxygen-limiting conditions can be affected by upstream activating mutations and increases the survival and growth of hypoxic tumor cells.	Oxygen	41-47	mechanistic target of rapamycin kinase	Homo sapiens	30-34
16099461-1	2006	We have reported that, in rats, hypoxia (10.8% O2) stimulates prolactin (PRL) release from the pituitary.	Oxygen	47-49	prolactin	Rattus norvegicus	73-76
16412252-3	2006	Here, we investigate the novel polymorphisms in exon 12, that approximate the oxygen-dependent degradation domain of HIF-1alpha in five cell lines and 28 patients with oral squamous carcinomas.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
16270338-6	2006	The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol.	Oxygen	4-10	fibrinogen beta chain	Homo sapiens	55-65
16270338-6	2006	The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol.	Oxygen	4-10	fibrinogen beta chain	Homo sapiens	183-193
16270338-6	2006	The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol.	Oxygen	213-219	fibrinogen beta chain	Homo sapiens	183-193
16439573-2	2006	The present study determined the expression of Kvbeta1 and four oxygen-sensitive Kvalpha subunits (Kv1.2, Kv1.5, Kv2.1, and Kv9.3) in the ductus arteriosus (DA), the aorta (Ao), and the pulmonary artery (PA) in porcine neonates immediately after birth.	Oxygen	64-70	potassium voltage-gated channel subfamily A member 2	Homo sapiens	99-104
16439573-2	2006	The present study determined the expression of Kvbeta1 and four oxygen-sensitive Kvalpha subunits (Kv1.2, Kv1.5, Kv2.1, and Kv9.3) in the ductus arteriosus (DA), the aorta (Ao), and the pulmonary artery (PA) in porcine neonates immediately after birth.	Oxygen	64-70	potassium voltage-gated channel subfamily A member 5	Homo sapiens	106-111
16439573-9	2006	Our findings suggest that the molecular basis for the differential electrophysiological characteristics including opposing response to oxygen in the DA and the PA are partially due to diversity in expression of Kv1.5 and Kvbeta1.2 subunits.	Oxygen	135-141	potassium voltage-gated channel subfamily A member 5	Homo sapiens	211-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	Oxygen	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
16176182-5	2006	Drosophila PHD has a low substrate specificity and hydroxylates key proline residues in the ODD (oxygen-dependent degradation) domains of human HIF-1alpha and Similar, the Drosophila homologue of HIF-1alpha.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
16176182-5	2006	Drosophila PHD has a low substrate specificity and hydroxylates key proline residues in the ODD (oxygen-dependent degradation) domains of human HIF-1alpha and Similar, the Drosophila homologue of HIF-1alpha.	Oxygen	97-103	similar	Drosophila melanogaster	196-206
16239610-0	2006	Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing: the "normobaric oxygen paradox".	Oxygen	96-102	erythropoietin	Homo sapiens	6-20
16239610-0	2006	Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing: the "normobaric oxygen paradox".	Oxygen	130-136	erythropoietin	Homo sapiens	6-20
16239610-4	2006	Serum EPO concentration was measured using a radioimmunoassay at various time points during 24-36 h. A 60% increase (P &lt; 0.001) in serum EPO was observed 36 h after normobaric oxygen.	Oxygen	179-185	erythropoietin	Homo sapiens	140-143
16239610-5	2006	In contrast, a 53% decrease in serum EPO was observed at 24 h after hyperbaric oxygen.	Oxygen	79-85	erythropoietin	Homo sapiens	37-40
16239610-7	2006	These results indicate that a sudden and sustained decrease in tissue oxygen tension, even above hypoxia thresholds (e.g., after a period of normobaric oxygen breathing), may act as a trigger for EPO serum level.	Oxygen	70-76	erythropoietin	Homo sapiens	196-199
16239610-7	2006	These results indicate that a sudden and sustained decrease in tissue oxygen tension, even above hypoxia thresholds (e.g., after a period of normobaric oxygen breathing), may act as a trigger for EPO serum level.	Oxygen	152-158	erythropoietin	Homo sapiens	196-199
16239610-8	2006	This EPO trigger, the "normobaric oxygen paradox," does not appear to be present after hyperbaric oxygen breathing.	Oxygen	34-40	erythropoietin	Homo sapiens	5-8
16254058-5	2006	An EGFP-fused protein demonstrated that the dominant-negative HIF-1alpha was nucleus-localized and constitutively expressed irrespective of oxygen tension.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
16407130-2	2006	Decreased oxygen delivery resulting from anemia induces the production of erythropoietin, which increases red cell production and hence oxygen delivery.	Oxygen	10-16	erythropoietin	Homo sapiens	74-88
16407130-2	2006	Decreased oxygen delivery resulting from anemia induces the production of erythropoietin, which increases red cell production and hence oxygen delivery.	Oxygen	136-142	erythropoietin	Homo sapiens	74-88
16407158-2	2006	It was previously demonstrated that Ero1p can transfer electrons from thiol substrates to molecular oxygen.	Oxygen	100-106	ER oxidoreductin	Saccharomyces cerevisiae S288C	36-41
16407158-5	2006	Under aerobic conditions, reduction of molecular oxygen by Ero1p yielded stoichiometric hydrogen peroxide.	Oxygen	49-55	ER oxidoreductin	Saccharomyces cerevisiae S288C	59-64
16407158-6	2006	Remarkably, we found that reduced Ero1p can transfer electrons to a variety of small and macromolecular electron acceptors in addition to molecular oxygen.	Oxygen	148-154	ER oxidoreductin	Saccharomyces cerevisiae S288C	34-39
17718406-4	2006	CYP2E1"s use of oxygen in alcohol metabolism generates reactive oxygen species, ultimately leading to oxidative stress and tissue damage.	Oxygen	16-22	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
16204254-9	2006	We thus conclude that mutation in the laminin alpha4 chain leads to abnormal cardiovascular ECM structure that cause insufficient oxygen supply to the heart and the subsequent ischemic cardiac phenotype observed.	Oxygen	130-136	laminin, alpha 4	Mus musculus	38-52
16489848-2	2006	In laboratory models of cardiac arrest, vasopressin improved vital organ blood flow, cerebral oxygen delivery, the rate of return of spontaneous circulation, and neurological recovery compared with epinephrine (adrenaline).	Oxygen	94-100	arginine vasopressin	Homo sapiens	40-51
17089888-5	2006	Using murine embryonic cells lacking cytochrome c, we show that mitochondrial reactive O2 species (ROS) are essential for O2 sensing and subsequent HIF alpha stabilization at 1.5% O2.	Oxygen	87-89	cytochrome c, somatic	Homo sapiens	37-49
17089888-5	2006	Using murine embryonic cells lacking cytochrome c, we show that mitochondrial reactive O2 species (ROS) are essential for O2 sensing and subsequent HIF alpha stabilization at 1.5% O2.	Oxygen	122-124	cytochrome c, somatic	Homo sapiens	37-49
17089888-9	2006	The cytochrome c mutant embryonic cells provide a unique reagent to further dissect the role of mitochondria in O2 mediated-intracellular events.	Oxygen	112-114	cytochrome c, somatic	Homo sapiens	4-16
16100289-3	2006	We found that TG hEC-SOD ameliorated the 95% O2-impaired bromodeoxyuridine uptake in alveolar and bronchiolar epithelium at P3, but not at P5 and P7, when overall epithelial proliferation rates were lower in air-exposed WT mice.	Oxygen	45-47	superoxide dismutase 3	Homo sapiens	17-24
16402910-4	2006	ABCG2 expression is upregulated under low-oxygen conditions, consistent with its high expression in tissues exposed to low-oxygen environments.	Oxygen	42-48	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
16402910-4	2006	ABCG2 expression is upregulated under low-oxygen conditions, consistent with its high expression in tissues exposed to low-oxygen environments.	Oxygen	123-129	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
16049063-0	2006	NF-kappaB in tracheal lavage fluid from intubated premature infants: association with inflammation, oxygen, and outcome.	Oxygen	100-106	nuclear factor kappa B subunit 1	Homo sapiens	0-9
16049063-6	2006	RESULTS: Square root transformed NF-kappaB concentrations were significantly related to signs of inflammation (cell count, p = 0.002; IL8, p = 0.019) and to simultaneous fraction of inspired oxygen in samples from the first 3 days of life (r = 0.512, p&lt;0.003).	Oxygen	191-197	nuclear factor kappa B subunit 1	Homo sapiens	33-42
16049063-8	2006	CONCLUSIONS: Tracheobronchial lavage NF-kappaB concentrations are related to lung inflammation, oxygen exposure, and pulmonary outcome in intubated preterm infants.	Oxygen	96-102	nuclear factor kappa B subunit 1	Homo sapiens	37-46
16417263-0	2006	Human serum albumin hybrid incorporating tailed porphyrinatoiron(II) in the alpha,alpha,alpha,beta-conformer as an O2-binding site.	Oxygen	115-117	albumin	Homo sapiens	6-19
16417263-1	2006	We have found that recombinant human serum albumin (HSA) incorporating tailed porphyrinatoiron(II) in the alpha,alpha,alpha,beta-conformer can reversibly bind and release O2 under physiological conditions (pH 7.3, 37 degrees C) like hemoglobin and myoglobin.	Oxygen	171-173	albumin	Homo sapiens	37-50
16192692-9	2006	RESULTS: Pure CD34(pos) cells from preterm (n = 5) and term (n = 5) neonates and from adults (n = 4) generated similar numbers of Mk colonies in all three oxygen concentrations.	Oxygen	155-161	CD34 molecule	Homo sapiens	14-18
17497004-3	2006	The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Oxygen	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17497012-6	2006	A conjugate of Co(II)-tetracarboxyphthalocyanine with the oligonucleotide was found to modify the DNA target in the presence of O(2) and 2-mercaptoethanol or in the presence of H(2)O(2).	Oxygen	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
16556156-4	2006	Some of them, like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are considered to play a major role in graft protection against oxygen stress during reperfusion.	Oxygen	160-166	superoxide dismutase 1	Homo sapiens	41-44
16556156-4	2006	Some of them, like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are considered to play a major role in graft protection against oxygen stress during reperfusion.	Oxygen	160-166	catalase	Homo sapiens	47-55
16556156-4	2006	Some of them, like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are considered to play a major role in graft protection against oxygen stress during reperfusion.	Oxygen	160-166	catalase	Homo sapiens	57-60
17187227-1	2006	Glucose-regulated protein 78 (GRP78) has been implicated in the protection of tumor cells from cytotoxic damage and apoptosis and thus assists cells in survival under oxygen-deprivation and nutrient-stress conditions.	Oxygen	167-173	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-28
17187227-1	2006	Glucose-regulated protein 78 (GRP78) has been implicated in the protection of tumor cells from cytotoxic damage and apoptosis and thus assists cells in survival under oxygen-deprivation and nutrient-stress conditions.	Oxygen	167-173	heat shock protein family A (Hsp70) member 5	Homo sapiens	30-35
17946181-7	2006	A useful ARX model is identified to justify the measured oxygen uptake dynamics within the aerobic range.	Oxygen	57-63	aristaless related homeobox	Homo sapiens	9-12
16028272-5	2006	The EF5 positive tissues were also specifically positive for nuclear-localized hypoxia inducible factor 1alpha (HIF-1alpha), the oxygen-sensitive component of the hypoxia inducible factor 1 (HIF-1) heterodimer.	Oxygen	129-135	hypoxia inducible factor 1 alpha subunit	Gallus gallus	79-110
17129364-1	2006	Supplementary arginine vasopressin infusion in advanced vasodilatory shock may be accompanied by a decrease in cardiac index and systemic oxygen transport capacity in approximately 40% of patients.	Oxygen	138-144	arginine vasopressin	Homo sapiens	23-34
16842166-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a key mediator of oxygen homeostasis that was first identified as a transcription factor that is induced and activated by decreased oxygen tension.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16842166-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a key mediator of oxygen homeostasis that was first identified as a transcription factor that is induced and activated by decreased oxygen tension.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16842166-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a key mediator of oxygen homeostasis that was first identified as a transcription factor that is induced and activated by decreased oxygen tension.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16842166-1	2006	Hypoxia-inducible factor-1 (HIF-1) is a key mediator of oxygen homeostasis that was first identified as a transcription factor that is induced and activated by decreased oxygen tension.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16028272-5	2006	The EF5 positive tissues were also specifically positive for nuclear-localized hypoxia inducible factor 1alpha (HIF-1alpha), the oxygen-sensitive component of the hypoxia inducible factor 1 (HIF-1) heterodimer.	Oxygen	129-135	hypoxia inducible factor 1 alpha subunit	Gallus gallus	112-122
20141508-5	2006	This is achieved either by directly coordinating to the metal ion found in some metalloenzymes (CAs, CPA, STS), usually by means of one of the nitrogen atoms present in the sulfamide motif, or, as in the case of the cyclic sulfamides, acting as HIV protease inhibitors interacting with the catalytically critical aspartic acid residues of the active site by means of an oxygen atom belonging to the HN-SO(2)-NH motif that substitutes a catalytically essential water molecule.	Oxygen	370-376	carboxypeptidase A1	Homo sapiens	101-104
16328220-1	2006	OBJECTIVE: To determine the effects of increasing dosages of continuously infused arginine-vasopressin (AVP) on mucosal tissue oxygen tension and oxygen supply in an auto-perfused, innervated jejunal segment in an acute endotoxic porcine model.	Oxygen	127-133	vasopressin	Sus scrofa	91-102
16575421-5	2006	In the present case a slight increase in the oxygen affinity of Hb J Meerut, relative to that of the normal control, has been observed as detected by low p50 values in arterial whole blood.	Oxygen	45-51	nuclear factor kappa B subunit 1	Homo sapiens	154-157
17160630-16	2006	Experimental data showed that on chronic ischemia, the signal triggering HIF-1alpha accumulation may disappear despite continuous hypoxia suggesting that compensatory mechanisms triggered during prolonged hypoxia may be able to restore normal tissue oxygen levels.	Oxygen	250-256	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
16291837-8	2006	Angiotensin II not only constricts efferent arterioles but, via its induction of oxidative stress, also hampers the efficient utilization of oxygen in tubular cells.	Oxygen	141-147	angiotensinogen	Homo sapiens	0-14
16328781-0	2006	Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.	Oxygen	11-17	vascular endothelial growth factor A	Homo sapiens	26-30
16328781-0	2006	Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.	Oxygen	11-17	mitogen-activated protein kinase 1	Homo sapiens	50-53
16328781-0	2006	Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.	Oxygen	11-17	mitogen-activated protein kinase 8	Homo sapiens	55-58
16715769-5	2006	In the presence of oxygen, the alpha subunit of HIF-1 (HIF-1alpha) is modified by hydroxylases, that represent the central point of the oxygen sensing mechanism.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-53
16173076-0	2006	Oxygen concentration influences mRNA processing and expression of the cd34 gene.	Oxygen	0-6	CD34 molecule	Homo sapiens	70-74
16173076-4	2006	An examination of CD34 regulation by a low O2 concentration that ensures a better maintenance of stem cells may provide important insights into the molecular control of hematopoiesis.	Oxygen	43-45	CD34 molecule	Homo sapiens	18-22
16173076-5	2006	Using human cord blood CD34+ cells, we first compared the effect of short term (24 h) culture in hypoxia (1% O2) and normoxia (20% O2) on the expression of full length and truncated form of cd34 transcripts and on the expression of the CD34 antigen.	Oxygen	109-111	CD34 molecule	Homo sapiens	190-194
16173076-7	2006	After 72 h of culture at 1% and 20% O2, sorted CD34low sub-population from 1% O2 primary culture still contained more cd34 full length mRNAs than those from 20% O2, maintained better CD34 antigen expression during secondary culture at 20% O2 and contained more undifferentiated cells.	Oxygen	36-38	CD34 molecule	Homo sapiens	47-51
16173076-7	2006	After 72 h of culture at 1% and 20% O2, sorted CD34low sub-population from 1% O2 primary culture still contained more cd34 full length mRNAs than those from 20% O2, maintained better CD34 antigen expression during secondary culture at 20% O2 and contained more undifferentiated cells.	Oxygen	36-38	CD34 molecule	Homo sapiens	118-122
16173076-7	2006	After 72 h of culture at 1% and 20% O2, sorted CD34low sub-population from 1% O2 primary culture still contained more cd34 full length mRNAs than those from 20% O2, maintained better CD34 antigen expression during secondary culture at 20% O2 and contained more undifferentiated cells.	Oxygen	78-80	CD34 molecule	Homo sapiens	47-51
16173076-7	2006	After 72 h of culture at 1% and 20% O2, sorted CD34low sub-population from 1% O2 primary culture still contained more cd34 full length mRNAs than those from 20% O2, maintained better CD34 antigen expression during secondary culture at 20% O2 and contained more undifferentiated cells.	Oxygen	78-80	CD34 molecule	Homo sapiens	47-51
16173076-7	2006	After 72 h of culture at 1% and 20% O2, sorted CD34low sub-population from 1% O2 primary culture still contained more cd34 full length mRNAs than those from 20% O2, maintained better CD34 antigen expression during secondary culture at 20% O2 and contained more undifferentiated cells.	Oxygen	78-80	CD34 molecule	Homo sapiens	47-51
16136272-7	2006	Following transfection of HIF1-alpha siRNA at 1% oxygen, PDGF-B expression was significantly suppressed at mRNA level.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-36
16374431-10	2006	Both HIFalpha isoforms are activated in the developing kidney in a cell-specific and temporally controlled manner, indicating a regulatory role of oxygen tension in nephrogenesis.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	5-13
16860490-13	2006	The combination of iron administration (by injection or oral rout), hemin, or transferrin, as a source for iron, HBO(2) as a source of oxygen under pressure and PDT as a source of generating free-radical tissue damage may be useful in the treatment of tumors.	Oxygen	135-141	transferrin	Homo sapiens	78-89
16551688-0	2006	Characterization of active oxygen-producing proteins in response to hypo-osmolarity in tobacco and Arabidopsis cell suspensions: identification of a cell wall peroxidase.	Oxygen	27-33	peroxidase	Arabidopsis thaliana	159-169
16551688-5	2006	In Arabidopsis, 30 kDa and 34 kDa proteins localized in the cell wall were shown to be able to produce active oxygen in the presence of cofactors and the production is prevented by peroxidase inhibitors, as is the in vivo response.	Oxygen	110-116	peroxidase	Arabidopsis thaliana	181-191
17392579-5	2006	After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P &lt; .05).	Oxygen	6-12	endothelin 1	Homo sapiens	24-28
16715769-5	2006	In the presence of oxygen, the alpha subunit of HIF-1 (HIF-1alpha) is modified by hydroxylases, that represent the central point of the oxygen sensing mechanism.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
16715769-5	2006	In the presence of oxygen, the alpha subunit of HIF-1 (HIF-1alpha) is modified by hydroxylases, that represent the central point of the oxygen sensing mechanism.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-53
16715769-5	2006	In the presence of oxygen, the alpha subunit of HIF-1 (HIF-1alpha) is modified by hydroxylases, that represent the central point of the oxygen sensing mechanism.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
16715769-9	2006	The role of HIF-1alpha is not restricted to the mere induction of adaptation to decreased oxygen: instead, it significantly participates in cell repairing mechanisms.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
17374968-6	2006	On the other hand, the expression of antiapoptotic Bcl-2 gene was increased by exposure to high-dose steroid hormones under a normoxic condition (20% O2).	Oxygen	150-152	B cell leukemia/lymphoma 2	Mus musculus	51-56
16046141-4	2006	Interestingly, intercepting activation of the caspases cascade is also effective in preventing both the mitochondrial damage and the increase in the production of reactive oxygen species induced by fALS-SOD1, even in the presence of cytochrome c release.	Oxygen	172-178	superoxide dismutase 1	Homo sapiens	203-207
17551265-2	2006	In the present study, we examine the differentiation ability of neural precursors expanded under lowered oxygen conditions, and the potential role of hypoxia-inducible factor (HIF)-1alphain vitro, which is the key molecule in response to lowered oxygen.	Oxygen	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-182
17551265-8	2006	The levels of HIF-1alpha mRNA expression under 3% oxygen did not change as compared with those under normal conditions.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
17551265-11	2006	These results suggest that HIF-1alpha is involved in the regulation of dopaminergic differentiation of NSCs in lowered oxygen.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
23074496-6	2006	CONVENTIONAL APPROACHES TO RESTORING THE BALANCE BETWEEN OXYGEN SUPPLY AND DEMAND FOCUS ON THE DISRUPTION OF THE UNDERLYING DISEASE THROUGH: drug therapy (beta blockers, calcium channel blockers, nitrates, antiplatelet agents, ACE inhibitors, statins); life-style modifications (smoking cessation, weight loss); or revascularization techniques such as coronary artery bypass graft surgery (CABG) or percutaneous coronary interventions (PCI).	Oxygen	57-63	angiotensin I converting enzyme	Homo sapiens	227-230
16775390-5	2006	UCP4 expressing cells also exhibited changes of oxygen-consumption rate, GDP sensitivity, and response of Deltapsim to oligomycin that were consistent with mitochondrial uncoupling.	Oxygen	48-54	solute carrier family 25, member 27	Rattus norvegicus	0-4
16686434-6	2006	Furthermore, good correlation was observed between data obtained from recombinant BK channels and those from acutely isolated rat carotid body glomus cells, suggesting strongly that HO-2 also acts as an O2 sensor in native arterial chemoreceptors.	Oxygen	203-205	heme oxygenase 2	Rattus norvegicus	182-186
16054700-3	2006	In response to changes in environmental factors such as oxygen tension, blood flow, circulating cytokines, and growth factors, the endothelium synthesizes and/or extracts many vasoactive mediators such as endothelin-1 (ET-1), norepinephrine, angiotensin 1, thromboxane, prostacyclin (PGI(2)), and the endothelial-derived relaxing factor nitric oxide (NO).	Oxygen	56-62	endothelin 1	Homo sapiens	205-217
16618987-4	2006	If the concentration of H2O2 is high, catalase acts catalytically, i.e. removes H2O2 by forming H2O and O2 (catalatic reaction).	Oxygen	26-28	catalase	Homo sapiens	38-46
17298220-2	2006	The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mitochondrial membrane, where it catalyzes the transfer of electrons form reduced cytochrome c to dioxygen, coupling this reaction with vectorial proton pumping across the inner membrane.	Oxygen	198-206	cytochrome c, somatic	Homo sapiens	182-194
16497108-6	2006	Catalase activity also correlated significantly with maximal oxygen consumption in long-distance runners.	Oxygen	61-67	catalase	Homo sapiens	0-8
16497108-8	2006	This different effect of the two training modules on catalase activity of long-distance runners might be partly due to the high oxygen load imposed during their repeated prolonged exercise bouts.	Oxygen	128-134	catalase	Homo sapiens	53-61
16686997-6	2006	This may due to the enzymatic ability of over-expressed CuZn-superoxide dismutase in Down syndrome to catalyze the formation of H2O2 from O2*-, thereby increasing the availability of substrate H2O2 for the iron-dependent generation of HO* via the Fenton reaction, suggesting that HO* generated from DS-GF may be involved in progressive periodontitis of Down syndrome.	Oxygen	130-132	superoxide dismutase 1	Homo sapiens	56-81
16470704-3	2006	Metal-catalyzed oxidation can mimic in vivo oxidation of amyloid beta because the metal ion binds to the amino acid residues at the site of oxidation, which then deliver reactive oxygen species to that site.	Oxygen	179-185	amyloid beta precursor protein	Homo sapiens	57-69
17259665-2	2006	Regulation of PPARgamma activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms.	Oxygen	142-148	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
16373281-8	2006	Splanchnic oxygen uptake showed a significant peak increase of 1.40 (0.44-4.13) mmol x min(-1) from a baseline level of 2.18 (1.41-3.31) mmol x min(-1).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	87-93
16541400-10	2006	Fe-EDTA/H2O2 and uncoupled CYP(Fe=O) may both initiate the reaction, the latter in an attempt to reduce the ferryl oxygen to water.	Oxygen	115-121	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-30
16373281-8	2006	Splanchnic oxygen uptake showed a significant peak increase of 1.40 (0.44-4.13) mmol x min(-1) from a baseline level of 2.18 (1.41-3.31) mmol x min(-1).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	144-150
16737181-7	2006	By means of inhibitory analysis, it has been established that processes of oxygen activation are related to arachidonic acid metabolism, and depend on the activity of phospholipase A2.	Oxygen	75-81	phospholipase A2 group IB	Homo sapiens	167-183
16140263-4	2005	Oxidation of LDL by the O2/cytochrome P450 cytochrome c reductase/NADPH/FeCl3 MFO system is only slightly higher (25%) in the bicarbonate/CO2 buffer as compared to phosphate buffer, but is dependent on all components except FeCl3.	Oxygen	24-26	cytochrome c, somatic	Homo sapiens	43-55
16257962-3	2005	We show in O2-sensitive excitable rat PC12 cells that, among the mtDNA-encoded genes, hypoxia produced a specific down-regulation of the transcripts encoding mitochondrial complex I NADH dehydrogenase (ND) subunits, particularly ND4 and ND5 mRNAs and a stable mRNA precursor containing the ND5 and cytochrome b genes.	Oxygen	11-13	NADH dehydrogenase 4, mitochondrial	Rattus norvegicus	229-232
16406803-3	2005	Unlike most P450s, which require exogenous reducing equivalents and an oxygen molecule for mono-oxygenation, PGIS catalyzes an isomerization with an initial step of endoperoxide bond cleavage of prostaglandin H(2) (PGH(2)).	Oxygen	71-77	prostaglandin I2 synthase	Homo sapiens	109-113
16269134-1	2005	Based on sequence alignments and homology modeling, threonine 309 in cytochrome P450 2D6 (CYP2D6) is proposed to be the conserved I-helix threonine, which is supposed to be involved in dioxygen activation by CYPs.	Oxygen	185-193	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	69-88
16269134-1	2005	Based on sequence alignments and homology modeling, threonine 309 in cytochrome P450 2D6 (CYP2D6) is proposed to be the conserved I-helix threonine, which is supposed to be involved in dioxygen activation by CYPs.	Oxygen	185-193	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	90-96
15957168-3	2005	The HIF-1alpha subunit is highly sensible to oxygen and is rapidly degraded by the proteasome 26S in normoxia.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
16869254-8	2006	Oxygen-dependent killing was controlled mostly by IL-6 during the pre-operative period, and by this plus TNF-alpha 24 hours after surgery.	Oxygen	0-6	interleukin 6	Homo sapiens	50-54
16869254-8	2006	Oxygen-dependent killing was controlled mostly by IL-6 during the pre-operative period, and by this plus TNF-alpha 24 hours after surgery.	Oxygen	0-6	tumor necrosis factor	Homo sapiens	105-114
16223732-1	2005	Continuous hydroxylation of the HIF-1 transcription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the transcriptional activation of many genes involved in energy metabolism, angiogenesis, cell survival, and matrix modification.	Oxygen	76-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
16223732-4	2005	Here we show that the glucose metabolites pyruvate and oxaloacetate inactivate HIF-1alpha decay in a manner selectively reversible by ascorbate, cysteine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.	Oxygen	212-218	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
16126163-0	2005	Hunting oxygen complexes of nitric oxide synthase at low temperature and high pressure.	Oxygen	8-14	nitric oxide synthase 2	Homo sapiens	28-49
16126163-1	2005	The reaction of nitric oxide synthase (NOS) with oxygen is fast and takes place within several steps, separated by ephemeral intermediates.	Oxygen	49-55	nitric oxide synthase 2	Homo sapiens	16-37
16154531-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16284183-11	2005	Perfusion of H2(O2) was sufficient to induce Akt activation.	Oxygen	16-18	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
16154531-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16154531-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability.	Oxygen	184-190	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16154531-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability.	Oxygen	184-190	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16154531-2	2005	In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.	Oxygen	135-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98
16373885-4	2005	METHODS: Ang/Tie2 gene expression was assessed in rats that had been exposed to hypoxia (ie, 10% O2) for 1, 3, or 7 days.	Oxygen	97-99	TEK receptor tyrosine kinase	Rattus norvegicus	13-17
16170370-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes.	Oxygen	104-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16170370-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes.	Oxygen	104-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16170370-3	2005	HIF-1alpha is degraded following enzyme-dependent hydroxylation of prolines of HIF-1alpha in the presence of molecular oxygen, Fe2+, alpha-ketoglutarate, and ascorbate.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16170370-3	2005	HIF-1alpha is degraded following enzyme-dependent hydroxylation of prolines of HIF-1alpha in the presence of molecular oxygen, Fe2+, alpha-ketoglutarate, and ascorbate.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
16337862-0	2005	Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
16337862-4	2005	Various other mechanisms might also contribute to HIF-1alpha expression, such as mutation of the oxygen dependent degradation domain (ODD), which prevents binding of prolyl-hydroxylases.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
16001425-0	2005	CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation.	Oxygen	60-66	DNA damage inducible transcript 3	Homo sapiens	0-4
16001425-5	2005	Our study revealed that the expression of the CEBP homologous protein (CHOP)-coding gene is promptly an intensely upregulated following astrocyte oxygen and glucose deprivation.	Oxygen	146-152	DNA damage inducible transcript 3	Homo sapiens	46-69
16001425-5	2005	Our study revealed that the expression of the CEBP homologous protein (CHOP)-coding gene is promptly an intensely upregulated following astrocyte oxygen and glucose deprivation.	Oxygen	146-152	DNA damage inducible transcript 3	Homo sapiens	71-75
16391483-0	2005	[Intravenous oxygen therapy increases the activity of the antioxidative and antiatherogenic serum enzyme paraoxonase 1].	Oxygen	13-19	paraoxonase 1	Homo sapiens	105-118
16391483-4	2005	OBJECTIVE: To evaluate the effect of repeated intravenous oxygen infusions on serum PON1 activity.	Oxygen	58-64	paraoxonase 1	Homo sapiens	84-88
16391483-10	2005	RESULTS: Using the substrate paraoxon PON1 activity significantly increased by 38% above basal levels 24 hours after intravenous oxygen infusion 9 (p &lt; 0.001).	Oxygen	129-135	paraoxonase 1	Homo sapiens	38-42
16391483-12	2005	CONCLUSION: Treatments with intravenous oxygen infusions evoke an adaptation to oxidative stress by an increase of serum PON1 activity.	Oxygen	40-46	paraoxonase 1	Homo sapiens	121-125
16391483-14	2005	PON1 activity is proposed to be an appropriate parameter for monitoring the success of this kind of oxygen therapy.	Oxygen	100-106	paraoxonase 1	Homo sapiens	0-4
16396835-3	2005	Here, we report on the molecular mechanism of HIF-1alpha IRES-mediated translation during oxygen deprivation.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
16396835-7	2005	In agreement with these results, the IRES activity of HIF-1alpha IRES deletion mutants that are deficient in PTB-binding could not be stimulated by oxygen deprivation.	Oxygen	148-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
16396835-8	2005	All together, our data suggest that PTB plays a stimulatory role in the IRES-mediated translation of HIF-1alpha when oxygen supply is limited.	Oxygen	117-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
16226717-5	2005	Reductase-catalyzed deformylation is unaffected by metal ion chelators and oxygen radical scavengers, but is strongly inhibited by catalase, and the catalase-mediated inhibition is prevented by azide.	Oxygen	75-81	catalase	Homo sapiens	149-157
16281953-2	2005	EPO production is inversely related to oxygen availability, so that an effective feedback loop is established, which controls erythropoiesis.	Oxygen	39-45	erythropoietin	Homo sapiens	0-3
16281953-4	2005	The main determinant of EPO synthesis is the transcriptional activity of its gene in liver and kidneys, which is related to local oxygen tensions.	Oxygen	130-136	erythropoietin	Homo sapiens	24-27
16281953-6	2005	In the presence of oxygen (normoxia) the HIFalpha subunits are hydroxylated, which targets them for proteasomal degradation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-49
16281953-9	2005	Although EPO is a prime example for an oxygen- regulated gene, the role of the HIF system goes far beyond the regulation of EPO, because it operates widely in almost all cells and controls a broad transcriptional response to hypoxia, including genes involved in cell metabolism, angiogenesis and vascular tone.	Oxygen	39-45	erythropoietin	Homo sapiens	9-12
16210396-3	2005	Abeta progressively accumulates in mitochondria and is associated with diminished enzymatic activity of respiratory chain complexes (III and IV) and a reduction in the rate of oxygen consumption.	Oxygen	176-182	amyloid beta precursor protein	Homo sapiens	0-5
16078234-0	2005	Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation.	Oxygen	107-113	dopamine receptor D3	Rattus norvegicus	0-27
16267663-1	2005	Two of the defining hallmarks of Alzheimer"s disease (AD) are deposits of the beta-amyloid peptide, Abeta, and the generation of reactive oxygen species, both of which may be due to the Abeta peptide coordinating metal ions.	Oxygen	138-144	amyloid beta precursor protein	Homo sapiens	186-191
16278294-4	2005	HIF-alpha/Sima is regulated by oxygen at several different levels that include protein stability and subcellular localization.	Oxygen	31-37	similar	Drosophila melanogaster	0-9
16278294-4	2005	HIF-alpha/Sima is regulated by oxygen at several different levels that include protein stability and subcellular localization.	Oxygen	31-37	similar	Drosophila melanogaster	10-14
16502647-2	2005	Based on a finite element model for insulin response to a glucose load in the presence of various oxygen supplies, the present study aimed at pointing out the major parameters influencing this secretion.	Oxygen	98-104	insulin	Homo sapiens	36-43
16311928-0	2005	Superoxide production and oxygen consumption in endothelium-intact and -denuded artery stimulated by angiotensin II.	Oxygen	26-32	angiotensinogen	Homo sapiens	101-115
16311928-4	2005	DPI treatment resulted in the expected increase in O2 consumption upon contractile activation with AII challenge (1.05+/- 0.23 micromol/g/min; n = 6, p &lt; .01), as did treatment with SOD (0.67+/- 0.20 micromol/g/min; n = 4, p &lt; .05).	Oxygen	51-53	angiotensinogen	Homo sapiens	99-102
16155211-1	2005	Hypoxia-induced gene expression is initiated when the hypoxia-inducible factor-1 (HIF-1) alpha subunit is stabilized in response to a lack of oxygen.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-94
16155211-2	2005	An HIF-1alpha-specific prolyl-hydroxylase (PHD) catalyzes hydroxylation of the proline-564 and/or -402 residues of HIF-1alpha by an oxygen molecule.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	3-13
16155211-2	2005	An HIF-1alpha-specific prolyl-hydroxylase (PHD) catalyzes hydroxylation of the proline-564 and/or -402 residues of HIF-1alpha by an oxygen molecule.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
16311928-5	2005	Catalase incubation resulted in a burst of O2 generation upon AII challenge (1.30 +/- 0.21 micromol/g/min; n = 10, p &lt; .001).	Oxygen	43-45	angiotensinogen	Homo sapiens	62-65
16311928-2	2005	We tested the hypothesis that superoxide (O2-) or other reactive oxidant species generated by AII played a role in the paradoxical O2 consumption response in porcine carotid artery, with or without an intact endothelium.	Oxygen	131-133	angiotensinogen	Homo sapiens	94-97
16311928-8	2005	An intact endothelium was required to manifest the burst of O2 generation with AII stimulation under normal conditions.	Oxygen	60-62	angiotensinogen	Homo sapiens	79-82
16286658-7	2005	These data suggest a unique mechanism for control of TCR signaling through Hif-1alpha, which may be operative at the physiologic oxygen tensions seen in solid lymphoid organs.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
16708805-5	2005	RESULTS: Before the treatment, there was a significant positive correlation between CRP and AHI in all subjects (r = 0.615, P &lt; 0.001), a significant negative correlation between CRP and the mean nocturnal oxygen saturation (r = -0.682, P &lt; 0.001), and a significant negative correlation between CRP and the lowest nocturnal SaO2 (r = -0.61, P &lt; 0.001).	Oxygen	209-215	C-reactive protein	Homo sapiens	182-185
16708805-5	2005	RESULTS: Before the treatment, there was a significant positive correlation between CRP and AHI in all subjects (r = 0.615, P &lt; 0.001), a significant negative correlation between CRP and the mean nocturnal oxygen saturation (r = -0.682, P &lt; 0.001), and a significant negative correlation between CRP and the lowest nocturnal SaO2 (r = -0.61, P &lt; 0.001).	Oxygen	209-215	C-reactive protein	Homo sapiens	182-185
16216223-1	2005	Hypoxia-inducible factor-1 (HIF-1), the major transcriptional regulator of the mammalian cellular response to low oxygen (hypoxia), is embedded within a complex network of signaling pathways.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16216223-1	2005	Hypoxia-inducible factor-1 (HIF-1), the major transcriptional regulator of the mammalian cellular response to low oxygen (hypoxia), is embedded within a complex network of signaling pathways.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16257394-2	2005	A key step in ROS detoxification is the conversion of hydrogen peroxide to water and oxygen by either catalase (CAT) or glutathione peroxidase (GPX).	Oxygen	85-91	catalase	Homo sapiens	102-110
16257394-2	2005	A key step in ROS detoxification is the conversion of hydrogen peroxide to water and oxygen by either catalase (CAT) or glutathione peroxidase (GPX).	Oxygen	85-91	catalase	Homo sapiens	112-115
16148002-13	2005	In the other pathway, myeloperoxidase uses superoxide to insert dioxygen into melatonin to form AFMK.	Oxygen	64-72	myeloperoxidase	Homo sapiens	22-37
16284587-2	2005	SUMMARY OF BACKGROUND DATA: We have recently shown that in a low oxygen environment, rat nucleus pulposus cells activate phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathways.	Oxygen	65-71	AKT serine/threonine kinase 1	Rattus norvegicus	151-154
16277537-1	2005	The binding properties of O2 and CO to recombinant human serum albumin (rHSA) mutants with a prosthetic heme group have been physicochemically and kinetically characterized.	Oxygen	26-28	albumin	Homo sapiens	57-70
16284587-2	2005	SUMMARY OF BACKGROUND DATA: We have recently shown that in a low oxygen environment, rat nucleus pulposus cells activate phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathways.	Oxygen	65-71	Eph receptor B1	Rattus norvegicus	247-250
16284587-7	2005	RESULTS: In a hypoxic environment (2% O2), rat nucleus pulposus cells showed a persistent phosphorylation of p38 and ERK proteins; pERK catalyzed the phosphorylation of Elk1-Gst fusion protein.	Oxygen	38-40	Eph receptor B1	Rattus norvegicus	117-120
16157596-2	2005	Recent evidence suggests that the transcription factor, HIF-1alpha, functions as a master regulator of oxygen homeostasis by controlling a broad range of cellular events in hypoxia.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Oxygen	201-207	androgen receptor	Homo sapiens	127-129
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Oxygen	201-207	androgen receptor	Homo sapiens	289-291
16157596-3	2005	In normoxia, HIF-1alpha is targeted for destruction via prolyl hydroxylation, an oxygen-dependent modification that signals for recognition by the ubiquitin ligase complex containing the von Hippel-Lindau tumor suppressor.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
16182243-1	2005	Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor 1alpha (HIF-1alpha) plays a central role in regulating transcriptional responses to hypoxia.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-82
16182243-1	2005	Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor 1alpha (HIF-1alpha) plays a central role in regulating transcriptional responses to hypoxia.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	225-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	225-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16182248-1	2005	Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	225-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
16552951-1	2005	BACKGROUND &amp; OBJECTIVE: Transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha) is a key determinant of oxygen-dependent gene regulation in angiogenesis.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-81
16552951-1	2005	BACKGROUND &amp; OBJECTIVE: Transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha) is a key determinant of oxygen-dependent gene regulation in angiogenesis.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
16099502-1	2005	Eu et al., reported that O2 dynamically controls the redox state of 6-8 out of 50 thiols per skeletal ryanodine receptor (RyR1) subunit and thereby tunes the response of Ca2+-release channels to authentic nitric oxide (NO) [J.P. Eu, J.	Oxygen	25-27	ryanodine receptor 1	Homo sapiens	122-126
15895231-6	2005	In a parallel series of in vitro experiments, cell cultures were exposed to hypoxia (0.1% or 0.7% O(2)) in a hypoxic chamber or normoxia for 24 h. We found a dose-dependent downregulation of HIF-1alpha by topotecan (30-270 nM).	Oxygen	98-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
15919729-5	2005	During exercise, mean arm O2 extraction correlated with the P(O2) value that causes hemoglobin to be 50% saturated (P50: r = 0.93, P &lt; 0.05), but for a given value of P50, O2 extraction was always higher in the legs than in the arms.	Oxygen	26-28	nuclear factor kappa B subunit 1	Homo sapiens	116-119
15919729-5	2005	During exercise, mean arm O2 extraction correlated with the P(O2) value that causes hemoglobin to be 50% saturated (P50: r = 0.93, P &lt; 0.05), but for a given value of P50, O2 extraction was always higher in the legs than in the arms.	Oxygen	62-64	nuclear factor kappa B subunit 1	Homo sapiens	116-119
16205110-3	2005	Previous reports have identified the existence of single nucleotide polymorphisms (SNPs) in the oxygen-dependent degradation domain of the HIF-1alpha gene in renal cell carcinoma, head and neck squamous cell carcinoma, and androgen-independent prostate cancer (AIPC).	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
16099502-4	2005	A role for O2 was based on the observation that RyR1 can be activated by submicromolar NO at physiological ( approximately 10 mmHg) but not ambient (approximately 150 mmHg) pO2.	Oxygen	11-13	ryanodine receptor 1	Homo sapiens	48-52
16256737-5	2005	The Notch intracellular domain interacts with HIF-1alpha, a global regulator of oxygen homeostasis, and HIF-1alpha is recruited to Notch-responsive promoters upon Notch activation under hypoxic conditions.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
16179946-0	2005	Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima.	Oxygen	52-58	HIF prolyl hydroxylase	Drosophila melanogaster	45-51
16099863-0	2005	Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension.	Oxygen	142-148	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	17-22
16099863-0	2005	Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-95
16099863-8	2005	To examine whether this up-regulation of Met was directly induced by HIF-1alpha, we performed the chromatin immunoprecipitation assay, which revealed that HIF-1alpha binds to the promoter region of the Met gene under low-oxygen tension.	Oxygen	221-227	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-165
16179946-0	2005	Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima.	Oxygen	52-58	similar	Drosophila melanogaster	90-114
16179946-1	2005	Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis.	Oxygen	133-139	similar	Drosophila melanogaster	0-24
16179946-1	2005	Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis.	Oxygen	133-139	similar	Drosophila melanogaster	26-29
16179946-2	2005	In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF-alpha polypeptides, thereby promoting their proteasomal degradation.	Oxygen	19-25	similar	Drosophila melanogaster	76-85
16179946-4	2005	Here, we describe novel loss-of-function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality.	Oxygen	97-103	HIF prolyl hydroxylase	Drosophila melanogaster	52-58
16280300-2	2005	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an oxygen-dependent transcriptional activator, which plays a crucial role in tumor angiogenesis.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
16280300-2	2005	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an oxygen-dependent transcriptional activator, which plays a crucial role in tumor angiogenesis.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
16278632-9	2005	On this context, an essential role is played by the hypoxia-induced factor-1alpha (HIF-1alpha) in terms of key transcription factor involved in oxygen-dependent gene regulation.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
16102994-13	2005	These results show that insulin regulates erythrocyte glycolysis and viability and suggest that this regulation is associated to other erythrocyte functions such as oxygen transport.	Oxygen	165-171	insulin	Homo sapiens	24-31
15935685-5	2005	Death of human neuronal precursor cells challenged by oxygen and glucose deprivation was increased by erythropoietin when cells were cultured under hypoxic but not under normoxic conditions.	Oxygen	54-60	erythropoietin	Homo sapiens	102-116
16183808-0	2005	Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B.	Oxygen	2-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-83
16183808-3	2005	We have studied NF-kappaB activation in hypoxic mice reoxygenated with either 21% O2 (room air) or 100% O2.	Oxygen	82-84	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-25
16183808-3	2005	We have studied NF-kappaB activation in hypoxic mice reoxygenated with either 21% O2 (room air) or 100% O2.	Oxygen	104-106	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-25
16183808-12	2005	Our data indicate that brain NF-kappaB activity is increased in mice subjected to 4% oxygen followed by reoxygenation with 100% oxygen.	Oxygen	85-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
16183808-12	2005	Our data indicate that brain NF-kappaB activity is increased in mice subjected to 4% oxygen followed by reoxygenation with 100% oxygen.	Oxygen	106-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
16278578-8	2005	Data was analyzed by generating receiver operating curves and the area under the curve was 0.889 (95% CI: 0.645-1.000) and 0.738 (95% CI: 0.413-1.000) for cytochrome c reduction and oxygen consumption respectively (1 indicates absolute predictive capability and 0.5 indicates no predictive capability).	Oxygen	182-188	cytochrome c, somatic	Homo sapiens	155-167
16185670-0	2005	Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2.	Oxygen	60-66	prostaglandin-endoperoxide synthase 2	Homo sapiens	9-46
16185670-0	2005	Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2.	Oxygen	60-66	mitogen-activated protein kinase 3	Homo sapiens	140-146
16185670-7	2005	These results indicate that PGHS-2 gene expression is induced by oxygen and glucose deprivation synergistically in neurons, and this induction is mediated by one or more members of the MAPK family.	Oxygen	65-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-34
16079130-1	2005	Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to degrade hydrogen peroxide into water and oxygen.	Oxygen	132-138	catalase	Homo sapiens	0-8
16107316-7	2005	In conclusion, visible and near-infrared light modifies the biochemical behavior of ATP in the hexokinase reaction and the fluorescence intensity of the molecule thus altering the Mg2+ binding strength to the oxygen atoms in the phosphate group.	Oxygen	209-215	hexokinase 1	Homo sapiens	95-105
16234508-1	2005	The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue.	Oxygen	165-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
16234508-1	2005	The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue.	Oxygen	165-171	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
16234508-1	2005	The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue.	Oxygen	165-171	erythropoietin	Homo sapiens	105-119
16234508-2	2005	Subsequently, a family of oxygen-dependent protein hydroxylases was found to regulate the abundance and activity of three oxygen-sensitive HIFalpha subunits, which, as part of the HIF heterodimer, regulated the transcription of at least 70 different effector genes.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-147
16202884-2	2005	The principle of the measurements was based on the determination of the decrease in the differentiation of oxygen level which had been caused by the inhibition of catalase in the bioactive layer of the biosensor by azide.	Oxygen	107-113	catalase	Homo sapiens	163-171
16081477-0	2005	Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans.	Oxygen	69-71	erythropoietin	Homo sapiens	31-45
16202857-6	2005	Insulin and Ang II stimulated O2- production by 34% and 35%, respectively (both P &lt; .05), but together synergistically stimulated it by 143% (P &lt; .05 versus insulin or Ang II) in a DPI or gp91ds-tat-sensitive manner.	Oxygen	30-32	angiotensinogen	Rattus norvegicus	12-18
16190729-8	2005	The structural and dynamic features of the CYP3A4-progesterone complex indicate that the oxidative degradation of progesterone occurs through hydroxylation at the C16 position by the reactive oxygen coordinated to the heme iron.	Oxygen	192-198	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49
15958730-9	2005	Because maternal and fetal endothelia must make dynamic adaptations to oxidative stress resulting from enhanced pregnancy-specific oxygen metabolism favoring prooxidant production, which is emerging as one of the leading causes of the dysfunctional activated endothelium during pregnancy, these unique features of CAV1 phosphorylation on oxidative stress observed implicate an important role of CAV1 in placental endothelial cell biology during pregnancy.	Oxygen	131-137	caveolin 1	Homo sapiens	314-318
16100226-10	2005	CONCLUSIONS: There is interspecies variation in glycolate oxidase activity associated with the granal development in the BS chloroplasts and the O2 production from photosystem II, which suggests different potential photorespiration capacities among C4 grasses.	Oxygen	145-147	hydroxyacid oxidase 2	Homo sapiens	48-65
15901600-1	2005	We recently reported that Na+/H+ exchanger isoform 1 (NHE1) activity in astrocytes is stimulated and leads to intracellular Na+ loading after oxygen and glucose deprivation (OGD).	Oxygen	142-148	solute carrier family 9 member A1	Homo sapiens	26-52
15901600-1	2005	We recently reported that Na+/H+ exchanger isoform 1 (NHE1) activity in astrocytes is stimulated and leads to intracellular Na+ loading after oxygen and glucose deprivation (OGD).	Oxygen	142-148	solute carrier family 9 member A1	Homo sapiens	54-58
15958730-9	2005	Because maternal and fetal endothelia must make dynamic adaptations to oxidative stress resulting from enhanced pregnancy-specific oxygen metabolism favoring prooxidant production, which is emerging as one of the leading causes of the dysfunctional activated endothelium during pregnancy, these unique features of CAV1 phosphorylation on oxidative stress observed implicate an important role of CAV1 in placental endothelial cell biology during pregnancy.	Oxygen	131-137	caveolin 1	Homo sapiens	395-399
16125437-2	2005	Recent discoveries place sGC in the H-NOX (heme nitric oxide and/or oxygen binding domain) family that includes bacterial proteins.	Oxygen	68-74	sarcoglycan beta	Homo sapiens	25-28
16234850-0	2005	Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition.	Oxygen	75-81	5'-aminolevulinate synthase 1	Homo sapiens	19-45
16200423-3	2005	Our conjecture is that this relationship describes a condition of predominant sympathetic activation, from which it is hypothesized that selective beta1-adrenergic blockade (BB) would reduce O(2) delivery (QaO(2)) and QvO(2).	Oxygen	191-195	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	147-152
16112903-8	2005	There were three main clinical determinants of NF-kappaB activation in PBL from CHF patients: peak oxygen consumption (r=0.53, p=0.025), presence of peripheral oedema (r=0.37, p&lt;0.05) and serum C-reactive protein (r=0.40, p=0.02).	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	47-56
15987707-7	2005	The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P&lt;0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P&lt;0.001).	Oxygen	303-309	C-reactive protein	Homo sapiens	25-43
16081065-1	2005	Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions in hypoxic tumor cells.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16081065-1	2005	Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions in hypoxic tumor cells.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16471171-8	2005	When the subjects were divided into two groups according to the change of plasma nitrotyrosine as an indicator of NO bioavailability, the subjects whose plasma nitrotyrosine decreased exhibited a significant relationship between the blood pressure-lowering effect of the lifestyle modification and the increase in EC-SOD, whereas those without a decrease in plasma nitrotyrosine exhibited a significant relationship between the blood pressure-lowering effect and the increase in maximum oxygen consumption.	Oxygen	487-493	superoxide dismutase 3	Homo sapiens	314-320
16136514-8	2005	This model incorporates the hypoxia-inducible factor alpha (HIF-1alpha) as an oxygen sensor and the hypoxia responsive facilitative glucose transporters, GLUT1 and GLUT3 as putative components of the glucose sensing apparatus in chondrocytes.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
16005113-2	2005	According to in vitro studies, microglia activated by amyloid-beta (Abeta) peptides have been reported to damage or kill neurons by the release of neurotoxic molecules such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, nitric oxide or reactive oxygen species.	Oxygen	261-267	amyloid beta precursor protein	Homo sapiens	54-66
16341774-8	2005	As a result, two parameters considered to be critical for controlling the release of mitochondrial cytochrome c on the induction of PT were mitochondrial volume and the velocity of mitochondrial oxygen consumption.	Oxygen	195-201	cytochrome c, somatic	Homo sapiens	99-111
16202925-8	2005	In contrast, when arteries were normalized at high stretch, constriction to ET-1 was greater at 38 than at 156 or 15 mm Hg oxygen and nifedipine inhibition of ET-1-induced constriction was greater at 38 and 15 mm Hg than at 156 mm Hg oxygen.	Oxygen	123-129	endothelin 1	Homo sapiens	76-80
16202925-9	2005	CONCLUSIONS: VGCCs and nifedipine-insensitive processes underlie the contractile response of chorionic plate arteries to ET-1 and their relative contribution to vasoconstriction is modulated by oxygen tension when vessels are normalized at high stretch.	Oxygen	194-200	endothelin 1	Homo sapiens	121-125
16005113-2	2005	According to in vitro studies, microglia activated by amyloid-beta (Abeta) peptides have been reported to damage or kill neurons by the release of neurotoxic molecules such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, nitric oxide or reactive oxygen species.	Oxygen	261-267	amyloid beta precursor protein	Homo sapiens	68-73
16142350-1	2005	HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16242072-4	2005	Here we show that, under hypoxic conditions (&lt; 2% O2), adenosine upregulates HIF-1alpha protein expression in a dose-dependent and time-dependent manner, exclusively through the A3 receptor subtype.	Oxygen	53-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
15947285-2	2005	Mechanisms that inhibit distal lung growth are poorly understood, but recent studies suggest that impaired vascular endothelial growth factor signaling and reduced nitric oxide (NO) production decreases alveolar and vessel growth in the developing lung, features observed in experimental oxygen-induced BPD.	Oxygen	288-294	vascular endothelial growth factor A	Homo sapiens	107-141
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	197-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	197-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	197-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	197-203	egl-9 family hypoxia inducible factor 1	Homo sapiens	249-269
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	197-203	egl-9 family hypoxia inducible factor 1	Homo sapiens	271-275
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	224-230	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	224-230	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
16185289-6	2005	HIF-1 is composed of two subunits, HIF-1alpha and HIF-1beta, and HIF-1 activity depends mainly on the intracellular level of HIF-1alpha protein, which is regulated to be in inverse relation to the oxygen concentration by an oxygen-dependent enzyme, prolyl hydroxylase 2 (PHD2).	Oxygen	224-230	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
16185289-7	2005	Thus, cells respond to tissue hypoxia by sensing the oxygen concentration as the enzyme activity of PHD2, regulating the HIF-1 activity and consequently changing the expression of various hypoxia-responsive molecules.	Oxygen	53-59	egl-9 family hypoxia inducible factor 1	Homo sapiens	100-104
16185289-7	2005	Thus, cells respond to tissue hypoxia by sensing the oxygen concentration as the enzyme activity of PHD2, regulating the HIF-1 activity and consequently changing the expression of various hypoxia-responsive molecules.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-126
16298626-3	2005	Cytoglobin is an intracellular oxygen-binding protein found in islet beta-cells, inducible by hypoxia.	Oxygen	31-37	cytoglobin	Rattus norvegicus	0-10
16298626-11	2005	Cytoglobin transfected islets and cells retained the ability to secrete insulin at low oxygen concentrations in contrast to controls.	Oxygen	87-93	cytoglobin	Rattus norvegicus	0-10
16173721-5	2005	An acid-catalyzed SN2" intramolecular alkylation of an acetal oxygen was followed by a one-pot sequence of beta-elimination and spiroketalization.	Oxygen	62-68	solute carrier family 38 member 5	Homo sapiens	18-21
15967517-0	2005	Accumulation and nuclear import of HIF1 alpha during high and low oxygen concentration in skeletal muscle cells in primary culture.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
15967517-5	2005	Immunofluorescence analysis reveals that under normoxic and high oxygen conditions, significant amounts of HIF1alpha can be found exclusively in the cytoplasm of the myotubes.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-116
16156633-7	2005	The potential for the catalytic electroreduction of O2 in HCl shifts negatively by 60 to 70 mV as compared to E(1/2) values in 1 M HClO4, consistent with the binding of Cl- to the Co(IV) form of the corrole and its rapid dissociation after electroreduction to Co(III) at the electrode surface.	Oxygen	52-54	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	260-267
15967517-4	2005	In view of this, we aimed to investigate HIF1alpha accumulation and subcellular localization as well as the transcriptional activity of the HIF1alpha-regulated gene of glyceraldehyde dehydrogenase (GAPDH) in skeletal muscle cells exposed to low oxygen concentration (3% O2), normoxia (20% O2) or high oxygen concentration (42% O2).	Oxygen	245-251	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15967517-7	2005	Under conditions of low oxygen, HIF1alpha in controls as well as in CoCl2-treated cells is found in the nuclei.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-41
15967517-8	2005	CdCl2 inhibits nuclear import of HIF1alpha at low oxygen concentration and leads to a transcriptional downregulation of the marker enzyme of anaerobic glycolysis GAPDH.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
15967517-4	2005	In view of this, we aimed to investigate HIF1alpha accumulation and subcellular localization as well as the transcriptional activity of the HIF1alpha-regulated gene of glyceraldehyde dehydrogenase (GAPDH) in skeletal muscle cells exposed to low oxygen concentration (3% O2), normoxia (20% O2) or high oxygen concentration (42% O2).	Oxygen	270-272	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15967517-9	2005	Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-39
16139272-3	2005	Nitration and phosphorylation of ERK1/2 by Ang II was significantly inhibited by NAD(P)H inhibitors and scavengers of oxygen and nitrogen reactive species and completely blocked by a selective inducible nitric-oxide synthase inhibitor.	Oxygen	118-124	angiotensinogen	Rattus norvegicus	43-49
15967517-4	2005	In view of this, we aimed to investigate HIF1alpha accumulation and subcellular localization as well as the transcriptional activity of the HIF1alpha-regulated gene of glyceraldehyde dehydrogenase (GAPDH) in skeletal muscle cells exposed to low oxygen concentration (3% O2), normoxia (20% O2) or high oxygen concentration (42% O2).	Oxygen	289-291	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15967517-4	2005	In view of this, we aimed to investigate HIF1alpha accumulation and subcellular localization as well as the transcriptional activity of the HIF1alpha-regulated gene of glyceraldehyde dehydrogenase (GAPDH) in skeletal muscle cells exposed to low oxygen concentration (3% O2), normoxia (20% O2) or high oxygen concentration (42% O2).	Oxygen	301-307	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15967517-4	2005	In view of this, we aimed to investigate HIF1alpha accumulation and subcellular localization as well as the transcriptional activity of the HIF1alpha-regulated gene of glyceraldehyde dehydrogenase (GAPDH) in skeletal muscle cells exposed to low oxygen concentration (3% O2), normoxia (20% O2) or high oxygen concentration (42% O2).	Oxygen	289-291	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15994299-0	2005	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.	Oxygen	115-121	nuclear receptor subfamily 1 group I member 2	Homo sapiens	23-42
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Oxygen	170-172	cytochrome c, somatic	Homo sapiens	93-105
16148937-3	2005	In mitochondria and many bacteria, the last enzyme complex in the electron transfer chain is cytochrome c oxidase (CytcO), which catalyses the four-electron reduction of O2 to H2O using electrons delivered by a water-soluble donor, cytochrome c.	Oxygen	170-172	cytochrome c, somatic	Homo sapiens	232-244
16124788-2	2005	Three tpip ligands form a shell around the lanthanide with the ligand coordinating via the two oxygens leading to neutral complexes, Ln(tpip)3.	Oxygen	95-102	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	Homo sapiens	6-10
15958387-3	2005	AMID is a flavoprotein; possesses NAD(P)H oxidase activity; and catalyzes NAD(P)H-dependent reduction of cytochrome c and other electron acceptors, including molecular oxygen.	Oxygen	168-174	cytochrome c, somatic	Homo sapiens	105-117
16131206-5	2005	EPR spectrum of Co(II)-ACMSD provides a high-spin (S = 3/2 mononuclear metal ion in a non-heme, noncorrinoid environment with a mixed nitrogen/oxygen ligand field.	Oxygen	143-149	aminocarboxymuconate semialdehyde decarboxylase	Homo sapiens	23-28
16124788-2	2005	Three tpip ligands form a shell around the lanthanide with the ligand coordinating via the two oxygens leading to neutral complexes, Ln(tpip)3.	Oxygen	95-102	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	Homo sapiens	136-140
16688932-11	2005	In conclusion, this study demonstrates an age-related decline in Cu/Zn-SOD and IDO activities, the two enzymes responsible for scavenging O2*-.	Oxygen	138-140	superoxide dismutase 1	Rattus norvegicus	65-74
16115043-4	2005	We examined the effect of pressure on oxygen-induced vascular endothelial growth factor (VEGF) expression by human HaCaT keratinocytes.	Oxygen	38-44	vascular endothelial growth factor A	Homo sapiens	53-87
16115043-4	2005	We examined the effect of pressure on oxygen-induced vascular endothelial growth factor (VEGF) expression by human HaCaT keratinocytes.	Oxygen	38-44	vascular endothelial growth factor A	Homo sapiens	89-93
16245689-4	2005	AChE is shown to hydrolyze only those substrates that form equilibrium conformers compatible in the mutual arrangement of trimethylammonium group, carbonyl carbon, and carbonyl oxygen with the tt conformation of ACh; in this case, the rate of substrate hydrolysis depends on the total population of these conformers.	Oxygen	177-183	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
16126907-6	2005	HIF-3alpha4 itself is oxygen-regulated, suggesting a novel feedback mechanism of controlling HIF-1 activity.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98
16123449-0	2005	KGF prevents oxygen-mediated damage in ARPE-19 cells.	Oxygen	13-19	fibroblast growth factor 7	Homo sapiens	0-3
16195986-4	2005	Absolute maximal oxygen uptake was significantly higher in elite than junior players (4.8 vs. 4.2 L x min(-1), p &lt; 0.01), but relative expressions, including allometric scaling, eliminated the difference.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	102-108
16039977-6	2005	Catalase adsorbed on MWCNTs exhibits a remarkable electrocatalytic activity toward the reduction of oxygen and hydrogen peroxide.	Oxygen	100-106	catalase	Homo sapiens	0-8
16110315-0	2005	Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
16140203-9	2005	These data suggest that cell death induced by lack of oxygen is predominantly apoptotic and can be prevented by pro-survival IGF-I signaling.	Oxygen	54-60	insulin like growth factor 1	Homo sapiens	125-130
16192672-13	2005	However, ozone/oxygen mixture induced a significant stimulation in the enzymatic activity of CAT, SOD, and glutathione peroxidase, as well as reduced glutathione in relation with Sham and positive control groups.	Oxygen	15-21	catalase	Rattus norvegicus	93-96
16054191-2	2005	A model to estimate the actual DO profile and the "sedimentary oxygen demand (SOD)" must specify the rate of microbial or chemical activity in the sediment as well as the diffusive supply of DO from the water column through the diffusive boundary layer into the sediment.	Oxygen	63-69	superoxide dismutase 1	Homo sapiens	78-81
16148071-0	2005	Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8.	Oxygen	43-45	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16148071-12	2005	Moreover, IL-8 concentration increased significantly in piglets that were resuscitated with 100% O2 compared with 21% O2, suggesting a marked proinflammatory response in the pulmonary tissue.	Oxygen	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
16148071-12	2005	Moreover, IL-8 concentration increased significantly in piglets that were resuscitated with 100% O2 compared with 21% O2, suggesting a marked proinflammatory response in the pulmonary tissue.	Oxygen	118-120	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
16039036-3	2005	The action of vasopressors in the heart, particularly beta1-adrenergic stimulation, is associated with adverse cardiac effects including post-resuscitation myocardial dysfunction, worsening ventricular arrhythmias, and increasing myocardial oxygen consumption.	Oxygen	241-247	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	54-59
16114794-8	2005	We also believe that the ACE inhibitor might have contributed to salvaging the kidney by improving medullary oxygen balance and maintaining adequate medullary blood flow.	Oxygen	109-115	angiotensin I converting enzyme	Homo sapiens	25-28
16103077-1	2005	Hypoxia that develops in solid tumors stabilizes the hypoxia-inducible factor-1alpha (HIF-1alpha) subunit of the HIF-1 transcription factor, leading to up-regulation of dozens of hypoxia-regulated genes that increase glycolysis and oxygen delivery.	Oxygen	232-238	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-84
16103077-1	2005	Hypoxia that develops in solid tumors stabilizes the hypoxia-inducible factor-1alpha (HIF-1alpha) subunit of the HIF-1 transcription factor, leading to up-regulation of dozens of hypoxia-regulated genes that increase glycolysis and oxygen delivery.	Oxygen	232-238	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
16103078-4	2005	We found that 24-hour hypoxia (&lt;0.1% O2) alone (no serum deprivation) showed sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) associated with bcl-2 up-regulation and resistance to etoposide-induced (5 mumol/L) apoptosis.	Oxygen	40-42	mitogen-activated protein kinase 1	Homo sapiens	104-145
16103078-4	2005	We found that 24-hour hypoxia (&lt;0.1% O2) alone (no serum deprivation) showed sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) associated with bcl-2 up-regulation and resistance to etoposide-induced (5 mumol/L) apoptosis.	Oxygen	40-42	mitogen-activated protein kinase 3	Homo sapiens	147-153
16103078-4	2005	We found that 24-hour hypoxia (&lt;0.1% O2) alone (no serum deprivation) showed sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) associated with bcl-2 up-regulation and resistance to etoposide-induced (5 mumol/L) apoptosis.	Oxygen	40-42	BCL2 apoptosis regulator	Homo sapiens	171-176
16094703-5	2005	HIF-1alpha could be detected in cancerous tissues in all patients, suggesting low oxygen tension in the tumors.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16158227-5	2005	Bcrp expression is induced under low oxygen conditions consistent with its high expression in tissues exposed to low oxygen environments.	Oxygen	37-43	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
16158227-5	2005	Bcrp expression is induced under low oxygen conditions consistent with its high expression in tissues exposed to low oxygen environments.	Oxygen	117-123	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
16158227-10	2005	We propose that Bcrp plays a role in porphyrin homoeostasis and regulates survival under low oxygen conditions.	Oxygen	93-99	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	16-20
16100168-3	2005	Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16100168-3	2005	Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16060655-1	2005	In cytochrome c oxidase (CcO), exergonic electron transfer reactions from cytochrome c to oxygen drive proton pumping across the membrane.	Oxygen	90-96	cytochrome c, somatic	Homo sapiens	3-15
16060655-1	2005	In cytochrome c oxidase (CcO), exergonic electron transfer reactions from cytochrome c to oxygen drive proton pumping across the membrane.	Oxygen	90-96	cytochrome c, somatic	Homo sapiens	74-86
16001273-0	2005	Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, treated by hyperbaric oxygen therapy: a quantitative immunohistochemical study.	Oxygen	158-164	BCL2, apoptosis regulator	Rattus norvegicus	52-57
15778277-0	2005	gp91phox-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II.	Oxygen	105-111	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	127-133
15778277-1	2005	We have previously reported that ANG II stimulation increased superoxide anion (O2-) through the activation of NAD(P)H oxidase and inhibited nitric oxide (NO)-dependent control of myocardial oxygen consumption (MVo2) by scavenging NO.	Oxygen	80-82	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	33-39
15778277-1	2005	We have previously reported that ANG II stimulation increased superoxide anion (O2-) through the activation of NAD(P)H oxidase and inhibited nitric oxide (NO)-dependent control of myocardial oxygen consumption (MVo2) by scavenging NO.	Oxygen	191-197	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	33-39
15778277-10	2005	ANG II resulted in significant increases in O2- production in WT mice, which was inhibited by coincubation with Tiron or apocynin.	Oxygen	44-46	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
16014049-0	2005	Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II.	Oxygen	0-6	angiotensinogen	Rattus norvegicus	80-94
15788485-7	2005	We also demonstrated that Etk utilizes a phosphatidylinositol 3-kinase/Akt pathway to promote reporter activation driven by NF-kappaB, another oxygen-sensitive transcription factor, and to augment cytokine-induced inducible nitric oxide synthase expression in endothelial cells.	Oxygen	143-149	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
15799019-6	2005	Furthermore, we demonstrated that overexpressed RTN3 and stimuli that activate both EOR and UPR, not UPR only, were able to induce up-regulation of inducible nitric oxide synthase (iNOS) in HeLa cells through ER Ca(2+) release and reactive oxygen intermediates (ROIs), resulting in endogenous calcium-dependent nitric oxide protecting cells against ER specific apoptosis, which suggested that the nitric oxide and iNOS represented a likely protective response to EOR, not the UPR.	Oxygen	240-246	nitric oxide synthase 2	Homo sapiens	148-179
15799019-6	2005	Furthermore, we demonstrated that overexpressed RTN3 and stimuli that activate both EOR and UPR, not UPR only, were able to induce up-regulation of inducible nitric oxide synthase (iNOS) in HeLa cells through ER Ca(2+) release and reactive oxygen intermediates (ROIs), resulting in endogenous calcium-dependent nitric oxide protecting cells against ER specific apoptosis, which suggested that the nitric oxide and iNOS represented a likely protective response to EOR, not the UPR.	Oxygen	240-246	nitric oxide synthase 2	Homo sapiens	181-185
15942765-10	2005	Analysis of EPOC data revealed that CT resulted in a significantly higher (p&lt;0.05) oxygen uptake during the first 30 min of recovery (0.27 +/- 0.01 l min(-1) vs 0.23+/-0.01 l min(-1)); though, at 60 min, treatment differences were not present.	Oxygen	86-92	CD59 molecule (CD59 blood group)	Homo sapiens	153-159
16026872-8	2005	Hypoxia (48-72 h of 0.2% O2) decreased RNA expression of a number of HR-related genes (e.g. Rad51, Rad52, Rad54, BRCA1, BRCA2) in both normal and malignant cultures.	Oxygen	25-27	RAD52 homolog, DNA repair protein	Homo sapiens	99-104
16099495-1	2005	Superoxide dismutases (SOD), a group of metal-containing enzymes, have a vital anti-oxidant role in human health, conferred by their scavenging of one of the reactive oxygen species, superoxide anion.	Oxygen	167-173	superoxide dismutase 1	Homo sapiens	0-21
16099495-1	2005	Superoxide dismutases (SOD), a group of metal-containing enzymes, have a vital anti-oxidant role in human health, conferred by their scavenging of one of the reactive oxygen species, superoxide anion.	Oxygen	167-173	superoxide dismutase 1	Homo sapiens	23-26
16024780-0	2005	Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-101
16024780-2	2005	The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated in the presence of oxygen, allowing the von Hippel-Lindau (VHL) E3 ubiquitin ligase to interact and target HIF-1alpha to the proteasome for degradation.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
16024780-2	2005	The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated in the presence of oxygen, allowing the von Hippel-Lindau (VHL) E3 ubiquitin ligase to interact and target HIF-1alpha to the proteasome for degradation.	Oxygen	205-211	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
16024780-4	2005	Here we show that the two ODDs of HIF-1alpha have independent yet interactive roles in the regulation of HIF-1alpha protein turnover, with the relative involvement of each ODD depending on the levels of oxygen.	Oxygen	203-209	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
16144688-0	2005	The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-29
15916908-2	2005	Recent studies have shown that a protein known as CSN5 or JAB1 interacts with both the HIF-1alpha oxygen-responsive transcription factor and its oxygen-dependent regulator, the Von Hippel-Lindau (pVHL) tumor suppressor.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
15916908-6	2005	This review will give a broad overview of known CSN5 and COP9 Signalosome functions and how these functions impact the pVHL/HIF-1alpha signaling complex and potentially other oxygen-sensitive response networks.	Oxygen	175-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
15936961-5	2005	We previously identified two PAS proteins highly expressed in the testis: a novel isoform of the hypoxia-inducible factor (HIF)-1alpha and PASKIN, a PAS-Ser/Thr kinase related to bacterial oxygen sensing PAS-domain proteins.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-134
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	lactate dehydrogenase A	Homo sapiens	244-267
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	lactate dehydrogenase A	Homo sapiens	269-274
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	lactate dehydrogenase A	Homo sapiens	275-279
16144688-0	2005	The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen.	Oxygen	80-86	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-38
16144688-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a critical regulator of the transcriptional response to low oxygen conditions (hypoxia/anoxia) experienced by mammalian cells in both physiological and pathophysiological circumstances.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
16144688-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a critical regulator of the transcriptional response to low oxygen conditions (hypoxia/anoxia) experienced by mammalian cells in both physiological and pathophysiological circumstances.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16144688-2	2005	As our understanding of the biology and biochemistry of HIF-1 has grown, it has become apparent that cells adapt to signals generated by low oxygen through a network of stress responsive transcription factors or complexes, which are influenced by HIF-1 activity.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-61
16144688-2	2005	As our understanding of the biology and biochemistry of HIF-1 has grown, it has become apparent that cells adapt to signals generated by low oxygen through a network of stress responsive transcription factors or complexes, which are influenced by HIF-1 activity.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	247-252
15996866-3	2005	A recent article provides in vitro biophysical evidence supporting a direct interaction between p53 and the oxygen-dependent degradation domain of the HIF-1alpha subunit.	Oxygen	108-114	tumor protein p53	Homo sapiens	96-99
15996866-3	2005	A recent article provides in vitro biophysical evidence supporting a direct interaction between p53 and the oxygen-dependent degradation domain of the HIF-1alpha subunit.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
16144688-3	2005	This review summarizes our current understanding of the interaction of HIF-1 with AP-1, a classic example of a family of pleiotropic transcription factors that impact on diverse cellular processes and phenotypes, including the adaptation to low oxygen stress.	Oxygen	245-251	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
16144688-3	2005	This review summarizes our current understanding of the interaction of HIF-1 with AP-1, a classic example of a family of pleiotropic transcription factors that impact on diverse cellular processes and phenotypes, including the adaptation to low oxygen stress.	Oxygen	245-251	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-86
15994012-1	2005	Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis and angiogenesis.	Oxygen	176-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15994012-1	2005	Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis and angiogenesis.	Oxygen	176-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16035955-2	2005	HIF-1alpha is the relevant, oxygen-dependent subunit and its overexpression has been associated with a poor prognosis in a variety of malignant tumours.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
15964510-11	2005	NO mediates oxygen-dependent injury in HeLa and MCF7 cells, by p38-dependent and MAPK-independent mechanisms, respectively.	Oxygen	12-18	mitogen-activated protein kinase 14	Homo sapiens	63-66
15967713-4	2005	Recently, PIS1 expression was found to be regulated in response to carbon source and oxygen availability.	Oxygen	85-91	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Saccharomyces cerevisiae S288C	10-14
15978586-1	2005	Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that mediates cellular and systemic homeostatic responses to reduce O2 availability, such as erythropoiesis, angiogenesis, and glycolysis.	Oxygen	136-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15883163-2	2005	This study was aimed to characterize the mitochondrial and extra-mitochondrial oxygen consuming reactions in human CD34+ hematopoietic stem cells.	Oxygen	79-85	CD34 molecule	Homo sapiens	115-119
15897903-1	2005	In the presence of oxygen and iron, hypoxia-inducible factor (HIF-1alpha) is rapidly degraded via the prolyl hydroxylases (PHD)/VHL pathways.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
15964510-8	2005	SB203580 inhibition of p38 MAPK appreciably protected HeLa and marginally protected MCF7 cells against oxygen-dependent irradiation injury, while the less specific JNK/SAPK inhibitor SP600125 and ERK inhibitor U0126 had no effect.	Oxygen	103-109	mitogen-activated protein kinase 14	Homo sapiens	23-26
15878209-8	2005	Oxygen uptake was stimulated in the perivenous area; in the periportal area it ranged from inhibition at low vasopressin concentrations to stimulation at high ones.	Oxygen	0-6	arginine vasopressin	Rattus norvegicus	109-120
15978586-1	2005	Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that mediates cellular and systemic homeostatic responses to reduce O2 availability, such as erythropoiesis, angiogenesis, and glycolysis.	Oxygen	136-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15978586-2	2005	Using the yeast two-hybrid screening system, we found that the oxygen dependent degradation (ODD) domain of HIF-1alpha interacts with necdin, a growth suppressor.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
15970707-1	2005	Under low oxygen tension, the activated transcription factor HIF-1alpha upregulates an array of hypoxia-inducible genes via heterodimerization with ARNT and binding to the hypoxia-responsive element in the promoter.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
15764677-0	2005	Arginine vasopressin reduces intestinal oxygen supply and mucosal tissue oxygen tension.	Oxygen	40-46	vasopressin	Sus scrofa	9-20
15764677-0	2005	Arginine vasopressin reduces intestinal oxygen supply and mucosal tissue oxygen tension.	Oxygen	73-79	vasopressin	Sus scrofa	9-20
16080536-2	2005	We investigated the impact of hypoxia (1% oxygen) on the expression of cathepsin B and its natural inhibitors cystatin B and C. MATERIALS AND METHODS: Patient-matched oral carcinoma cell lines from primary tumor and lymph node metastasis were used to study the effects of hypoxia on proliferation, protein expression, and proteolytic and inhibitor activities.	Oxygen	42-48	cystatin B	Homo sapiens	110-120
15863483-7	2005	The results show that the negatively charged carboxyl oxygens of D4899 and E4900 side chains are major determinants of RyR ion conductance and selectivity.	Oxygen	54-61	ryanodine receptor 1	Homo sapiens	119-122
15994954-7	2005	Our studies imply that antivascular and antiangiogenesis therapy that results in severe glucose and oxygen deprivation will induce GRP78 expression that could lead to drug resistance.	Oxygen	100-106	heat shock protein family A (Hsp70) member 5	Homo sapiens	131-136
16012039-2	2005	CONCLUSION: Our experience confirms that pectoralis major flap is the first-choice technique for repairing recurrent hypopharyngeal fistulae in previously irradiated patients in whom microsurgical techniques are not indicated, and that hyperbaric oxygen therapy helps to solve this complex pathology.	Oxygen	247-253	arachidonate 5-lipoxygenase activating protein	Homo sapiens	58-62
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	269-276	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
16000563-4	2005	RESULTS: We observed that low glucose and low glutamine, but not low pyruvate, effectively suppressed the elevation of HIF-1alpha level during hypoxia (0.1-1% oxygen).	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	348-355	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
15934728-5	2005	(18)O isotope tracing shows that H(2)O is the source of oxygen transferred to PPh(3).	Oxygen	56-62	caveolin 1	Homo sapiens	78-84
15994384-4	2005	IL-1beta (10 ng x mL(-1); 21 degrees C; 15 h) increased the release of NGF from human isolated bronchi in vitro, and, in organ bath studies, the response of human bronchi to [Sar9,Met(O2)11]-substance P (0.1 microm).	Oxygen	184-186	interleukin 1 beta	Homo sapiens	0-8
15878931-4	2005	Studies performed with purified PGHS-2 revealed maximal elevation of enzyme activity in the presence of equimolar concentrations of *NO and *O2-, which together form peroxynitrite, while excessive production of either one radical was inhibitory.	Oxygen	141-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	32-38
16000716-0	2005	Effect of static growth and different levels of environmental oxygen on toxA and ptxR expression in the Pseudomonas aeruginosa strain PAO1.	Oxygen	62-68	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	81-85
16095223-6	2005	She was treated by 38 times of the hyperbaric oxygen therapy with cytochrome C and fully recovered.	Oxygen	46-52	cytochrome c, somatic	Homo sapiens	66-78
15950061-10	2005	Reduced oxygen fraction, FGF-4 and FGF-10 stimulated Spry-2 expression.	Oxygen	8-14	sprouty RTK signaling antagonist 2	Homo sapiens	53-59
15917188-5	2005	Hydrogen peroxide was implicated in the response as catalase prevented the increase in oxygen consumption normally associated with high oxygen.	Oxygen	87-93	catalase	Homo sapiens	52-60
15917188-5	2005	Hydrogen peroxide was implicated in the response as catalase prevented the increase in oxygen consumption normally associated with high oxygen.	Oxygen	136-142	catalase	Homo sapiens	52-60
15985531-0	2005	Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.	Oxygen	9-15	a disintegrin and metallopeptidase domain 17	Mus musculus	34-61
15705733-1	2005	Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death.	Oxygen	168-174	PPARG coactivator 1 alpha	Homo sapiens	46-113
15705733-1	2005	Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death.	Oxygen	168-174	PPARG coactivator 1 alpha	Homo sapiens	115-123
15705733-1	2005	Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death.	Oxygen	185-187	PPARG coactivator 1 alpha	Homo sapiens	46-113
15705733-1	2005	Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death.	Oxygen	185-187	PPARG coactivator 1 alpha	Homo sapiens	115-123
15883010-0	2005	Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1.	Oxygen	28-30	potassium two pore domain channel subfamily K member 2	Homo sapiens	77-83
16030390-8	2005	Our results show that SOD and CAT can protect neutrophils against NO-donors-induced apoptosis and suggest that the interaction of NO and oxygen metabolites signals may determine the destructive or protective role of NO donor compounds during apoptotic neutrophil death.	Oxygen	137-143	superoxide dismutase 1	Homo sapiens	22-25
15924420-1	2005	Each homologous lobe of human serum transferrin (hTF) has one Fe(3+) ion bound by an aspartic acid, a histidine, two tyrosine residues, and two oxygens from the synergistic anion, carbonate.	Oxygen	144-151	transferrin	Homo sapiens	36-47
15923516-3	2005	Angiogenesis is controlled by among other factors the expression of vascular endothelial growth factor (VEGF), which in turn is regulated by absolute and relative lack of oxygen.	Oxygen	171-177	vascular endothelial growth factor A	Homo sapiens	68-102
15923516-3	2005	Angiogenesis is controlled by among other factors the expression of vascular endothelial growth factor (VEGF), which in turn is regulated by absolute and relative lack of oxygen.	Oxygen	171-177	vascular endothelial growth factor A	Homo sapiens	104-108
15778089-9	2005	These data suggest that amplification of c-myb in tumor cells may lead to robust GRP78 gene induction, which may in turn assist cells in survival under conditions of oxygen deprivation and nutrient stress.	Oxygen	166-172	heat shock protein family A (Hsp70) member 5	Homo sapiens	81-86
16054088-0	2005	Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.	Oxygen	79-85	cytochrome c, somatic	Homo sapiens	49-61
16054088-5	2005	These results provide genetic evidence indicating that mtROS act upstream of prolyl hydroxylases in regulating HIF-1 alpha and HIF-2 alpha in this O(2)-sensing pathway.	Oxygen	147-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-122
16054089-4	2005	These results demonstrate that mitochondria function as O(2) sensors and signal hypoxic HIF-1 alpha and HIF-2 alpha stabilization by releasing ROS to the cytosol.	Oxygen	56-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-99
15959796-5	2005	In previous studies, we have demonstrated that Kupffer cells isolated from rats with CCl4-induced steatonecrosis produced more reactive oxygen intermediates than cells isolated from normal rats.	Oxygen	136-142	C-C motif chemokine ligand 4	Rattus norvegicus	85-89
15943813-8	2005	Comparison of the Rio2-ATP-Mn complex with the Rio2 structure with no added nucleotides and with the ADP complex indicates that a flexible portion of the Rio2 molecule becomes ordered through direct interaction between His126 and the gamma-phosphate oxygen of ATP.	Oxygen	250-256	protein kinase RIO2	Saccharomyces cerevisiae S288C	18-22
15943813-8	2005	Comparison of the Rio2-ATP-Mn complex with the Rio2 structure with no added nucleotides and with the ADP complex indicates that a flexible portion of the Rio2 molecule becomes ordered through direct interaction between His126 and the gamma-phosphate oxygen of ATP.	Oxygen	250-256	protein kinase RIO2	Saccharomyces cerevisiae S288C	47-51
15943813-8	2005	Comparison of the Rio2-ATP-Mn complex with the Rio2 structure with no added nucleotides and with the ADP complex indicates that a flexible portion of the Rio2 molecule becomes ordered through direct interaction between His126 and the gamma-phosphate oxygen of ATP.	Oxygen	250-256	protein kinase RIO2	Saccharomyces cerevisiae S288C	47-51
16407994-6	2005	These data suggest that sGC uses a kinetic selection against O2; we propose that the O2 dissociation rate in the absence of this tyrosine is fast and that a stable O2 complex does not form.	Oxygen	61-63	sarcoglycan beta	Homo sapiens	24-27
15957953-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional complex that has been recognized primarily for its role in the maintenance of oxygen and energy homoeostasis.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15957953-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional complex that has been recognized primarily for its role in the maintenance of oxygen and energy homoeostasis.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16195006-2	2005	The average oxygen uptake for international soccer teams ranges from 55 to 68 ml.kg-1.min-1 and the half-squat maximal strength from 120 to 180 kg.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
16187223-6	2005	On the other hand, by inducing the production and release of inflammatory cytokines, reactive oxygen molecules and excitotoxins, activation of NF-kappaB in microglia and astrocytes may contribute to neuronal degeneration.	Oxygen	94-100	nuclear factor kappa B subunit 1	Homo sapiens	143-152
15888316-1	2005	Mutations in the mev-1 and gas-1 genes of the nematode Caenorhabditis elegans render animals hypersensitive to oxygen and paraquat, and lead to premature aging.	Oxygen	111-117	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	17-22
17220917-6	2005	The percentage of oxygen saturation (SPO((2)) of both the subjects and their control population was determined using a pulse oximeter.	Oxygen	18-24	synaptoporin	Homo sapiens	37-40
16407994-6	2005	These data suggest that sGC uses a kinetic selection against O2; we propose that the O2 dissociation rate in the absence of this tyrosine is fast and that a stable O2 complex does not form.	Oxygen	85-87	sarcoglycan beta	Homo sapiens	24-27
16407994-6	2005	These data suggest that sGC uses a kinetic selection against O2; we propose that the O2 dissociation rate in the absence of this tyrosine is fast and that a stable O2 complex does not form.	Oxygen	85-87	sarcoglycan beta	Homo sapiens	24-27
15922018-2	2005	FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate.	Oxygen	42-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	10-25
15911074-6	2005	Several cis-responsive elements of the ANP promoter are involved in the response to changes in oxygen tension.	Oxygen	95-101	natriuretic peptide A	Homo sapiens	39-42
15922018-2	2005	FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate.	Oxygen	42-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	27-30
15781453-1	2005	The human hypoxia-inducible transcription factor HIF-1 is a critical regulator of cellular and systemic responses to low oxygen levels.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
15896821-8	2005	In the presence of sunlight and dissolved oxygen, As(III) (26.7 microM or 2mg/L) was completely converted to As(V) in a 0.2g/L TiO(2) suspension through photocatalytic oxidation within 25 min.	Oxygen	42-48	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	109-114
15923322-8	2005	Ethylene signaling mutants (ein2 and etr1) and reactive oxygen metabolism mutants (vtc1, vtc2, npq1, and cad2) were more defective in basal than acquired thermotolerance, especially under high light.	Oxygen	56-62	cinnamyl alcohol dehydrogenase homolog 2	Arabidopsis thaliana	105-109
15750626-6	2005	Investigation of both N-terminal and C-terminal (aa 727-826) oxygen-regulated proline and asparagine hydroxylation of HIF-1alpha revealed that both are inhibited during high cell density, as determined by impaired capture of HIF-1alpha by VHL and enhanced C-terminal transactivation.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
15750626-6	2005	Investigation of both N-terminal and C-terminal (aa 727-826) oxygen-regulated proline and asparagine hydroxylation of HIF-1alpha revealed that both are inhibited during high cell density, as determined by impaired capture of HIF-1alpha by VHL and enhanced C-terminal transactivation.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	225-235
16852273-2	2005	One of the dimers is a model of the active site of manganese catalase, while another represents a basic building block of the oxygen-evolving complex in photosystem II.	Oxygen	126-132	catalase	Homo sapiens	61-69
15916947-2	2005	In C. elegans, an atypical O2 binding soluble guanylate cyclase (sGC), GCY-35, regulates O2 responses.	Oxygen	27-29	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	71-77
15916947-2	2005	In C. elegans, an atypical O2 binding soluble guanylate cyclase (sGC), GCY-35, regulates O2 responses.	Oxygen	89-91	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	71-77
15916947-5	2005	This aerokinetic response is mediated by GCY-35 and GCY-36 sGCs, which appear to become activated as O2 levels drop and to depolarize the AQR, PQR, and URX neurons.	Oxygen	101-103	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	41-47
15916947-6	2005	Coexpression of GCY-35 and GCY-36 is sufficient to transform olfactory neurons into O2 sensors.	Oxygen	84-86	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	16-22
15757894-8	2005	We conclude that mitochrondrially derived reactive oxygen from Ucp2-/- cells constitutively activates NF-kappa B, resulting in a "primed" state to both potentiate and amplify the inflammatory response upon subsequent stimulation.	Oxygen	51-57	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	63-67
15878343-1	2005	Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1alpha and one HIF-1beta subunit.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15878343-1	2005	Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1alpha and one HIF-1beta subunit.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15878343-1	2005	Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1alpha and one HIF-1beta subunit.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
15538748-3	2005	METHODS: A series of 15 metastatic androgen independent prostate cancers were examined for mutations in the oxygen-dependent domain (ODD) of HIF-1alpha by PCR amplification and DNA sequencing.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
16008970-11	2005	IL-6 level in EBC was correlated positively with AHI (r = 0.441, P &lt; 0.05), ODI(4) (r = 0.533, P &lt; 0.05), and negatively with minimal oxygen saturation (r = -0.529, P &lt; 0.05).	Oxygen	140-146	interleukin 6	Homo sapiens	0-4
15757894-8	2005	We conclude that mitochrondrially derived reactive oxygen from Ucp2-/- cells constitutively activates NF-kappa B, resulting in a "primed" state to both potentiate and amplify the inflammatory response upon subsequent stimulation.	Oxygen	51-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-112
15901372-9	2005	RESULTS &amp; CONCLUSIONS: HIF-1alpha expression occurred following exposure of cells to 3% oxygen for 8 h in all three cell lines, and its expression was found to be dependent on NOS activity, being reduced or inhibited by L-NMMA.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
15851671-1	2005	Cytochrome c (CYC) oxidase (COX), a multisubunit enzyme that functions in mitochondrial aerobic energy production, catalyzes the transfer of electrons from CYC to oxygen and participates in creating the electrochemical gradient used for ATP synthesis.	Oxygen	163-169	cytochrome c, somatic	Homo sapiens	0-12
15851671-1	2005	Cytochrome c (CYC) oxidase (COX), a multisubunit enzyme that functions in mitochondrial aerobic energy production, catalyzes the transfer of electrons from CYC to oxygen and participates in creating the electrochemical gradient used for ATP synthesis.	Oxygen	163-169	cytochrome c, somatic	Homo sapiens	14-17
15851671-1	2005	Cytochrome c (CYC) oxidase (COX), a multisubunit enzyme that functions in mitochondrial aerobic energy production, catalyzes the transfer of electrons from CYC to oxygen and participates in creating the electrochemical gradient used for ATP synthesis.	Oxygen	163-169	cytochrome c, somatic	Homo sapiens	156-159
15851671-3	2005	Because of the functional importance of the transfer of electrons to oxygen, it might be expected that natural selection would drastically constrain amino acid replacement rates of CYC and COX.	Oxygen	69-75	cytochrome c, somatic	Homo sapiens	181-184
15840558-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a key regulator of cellular responses to reduced oxygen availability.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15840558-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a key regulator of cellular responses to reduced oxygen availability.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15890018-1	2005	Exposure to chronic oxidative stress during elevated oxygen (hyperoxia) damages DNA and inhibits cell proliferation in G(1) through induction of the cyclin-dependent kinase inhibitor p21.	Oxygen	53-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	183-186
15862307-1	2005	Exposure to limiting oxygen in cells and tissues induce the stabilization and transcriptional activation of the hypoxia-inducible factor 1 alpha (HIF-1alpha) protein, a key regulator of the hypoxic response.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-144
15862307-1	2005	Exposure to limiting oxygen in cells and tissues induce the stabilization and transcriptional activation of the hypoxia-inducible factor 1 alpha (HIF-1alpha) protein, a key regulator of the hypoxic response.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
15862307-4	2005	Our results show that under conditions of reduced oxygen (3% O(2)), MitoQ ablated the hypoxic induction of ROS generation and destabilized HIF-1alpha protein.	Oxygen	61-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
15797310-7	2005	Wound inducible nitric oxide synthase (iNOS), modulated by psychological stress and oxygen balance, was studied for gene expression by real-time PCR.	Oxygen	84-90	nitric oxide synthase 2, inducible	Mus musculus	6-37
15797310-7	2005	Wound inducible nitric oxide synthase (iNOS), modulated by psychological stress and oxygen balance, was studied for gene expression by real-time PCR.	Oxygen	84-90	nitric oxide synthase 2, inducible	Mus musculus	39-43
15879029-1	2005	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15879029-1	2005	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15879029-1	2005	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15879029-1	2005	Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15850830-10	2005	RESULTS: Among the five cell lines, UT-7/Epo exhibited active pseudopodial extension in hypoxia (1% O2), and cell motility was increased.	Oxygen	100-102	erythropoietin	Homo sapiens	41-44
15804511-3	2005	Since blood is the major oxygen storage site in marine mammals, it was hypothesized that EPO may have a significant influence on the development of hematology parameters associated with the expansion of blood oxygen stores during development.	Oxygen	25-31	erythropoietin	Homo sapiens	89-92
16004370-5	2005	The presence of a catalase enzyme system in the Microsporidia was first made evident by the detection of significant levels of molecular oxygen in the medium containing discharging spores in the presence of hydrogen peroxide.	Oxygen	137-143	catalase	Homo sapiens	18-26
15804511-3	2005	Since blood is the major oxygen storage site in marine mammals, it was hypothesized that EPO may have a significant influence on the development of hematology parameters associated with the expansion of blood oxygen stores during development.	Oxygen	209-215	erythropoietin	Homo sapiens	89-92
15895734-7	2005	Under 10 and 15% oxygen conditions, neurotoxin was not detected after 1 week of storage, but sample spoilage was detected after the same period.	Oxygen	17-23	neurotoxin	Clostridium botulinum	36-46
15765501-6	2005	These performances were related to the surface morphology, to the film calcium/phosphate ratio and its surface oxygen content, as well as to a preferential binding of structural proteins such as fibronectin.	Oxygen	111-117	fibronectin 1	Homo sapiens	195-206
15895734-8	2005	Under 0% oxygen conditions, neurotoxin was detected at 1 week, but the sample remained organoleptically acceptable even after 2 weeks of storage.	Oxygen	9-15	neurotoxin	Clostridium botulinum	28-38
15895734-9	2005	Both neurotoxin and sample spoilage were detected at 1 week of storage under 5% oxygen conditions.	Oxygen	80-86	neurotoxin	Clostridium botulinum	5-15
16176069-0	2005	Endoplasmic reticulum dysfunction and Ca2+ deregulation in isolated CA1 neurons during oxygen and glucose deprivation.	Oxygen	87-93	carbonic anhydrase 2	Rattus norvegicus	38-41
15874902-8	2005	DAN-G cells cultured in an (18)O(2) atmosphere produced (S)-[ (18)O(2)]-norlaudanosoline and (S)-[ (18)O(2)]-reticuline, each labeled with (18)O atoms at only two of the four possible positions.	Oxygen	30-35	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
15829290-7	2005	When it comes to the arena of oxygen sensing, oxidative stress and inflammation, nuclear factor-kappaB (NF-kappaB) and hypoxia-inducible factor-1alpha (HIF-1alpha) are key players that determine antioxidant/prooxidant responses with oxidative challenge.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-150
15829290-7	2005	When it comes to the arena of oxygen sensing, oxidative stress and inflammation, nuclear factor-kappaB (NF-kappaB) and hypoxia-inducible factor-1alpha (HIF-1alpha) are key players that determine antioxidant/prooxidant responses with oxidative challenge.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
15708444-3	2005	Here we describe the effect of reduced DAF-2 signaling on several parameters of metabolism including rates of oxygen consumption and heat output, the calorimetric/respirometric ratio, ATP levels, XTT reduction capacity and accumulation of lipofuscin.	Oxygen	110-116	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	39-44
15563275-4	2005	Therefore PHD2 is regarded as the main cellular oxygen sensor.	Oxygen	48-54	egl-9 family hypoxia inducible factor 1	Homo sapiens	10-14
15695372-1	2005	Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-independent manner.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15695372-1	2005	Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-independent manner.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
16176069-2	2005	The aim of the present study was to investigate the routes of Ca2+ entry during non-excitotoxic oxygen and glucose deprivation (OGD) in acutely dissociated rat CA1 neurons.	Oxygen	96-102	carbonic anhydrase 2	Rattus norvegicus	62-65
15823455-2	2005	Recent observations suggest that reactive oxygen intermediates may play a pivotal role in TNF-alpha signaling and upregulate gene expression.	Oxygen	42-48	tumor necrosis factor	Homo sapiens	90-99
15716268-4	2005	In PC12 cells, increased expression of the NAD-dependent deacetylase SIRT1 reduces cellular oxygen consumption by approximately 25%.	Oxygen	92-98	sirtuin 1	Rattus norvegicus	69-74
15860771-7	2005	The combination of specific zinc finger transcription factors and siRNAs greatly enhanced the silencing of the human VEGF-A gene, not only when cells were grown in the presence of normal amounts of oxygen but also under conditions of hypoxic stimulation.	Oxygen	198-204	vascular endothelial growth factor A	Homo sapiens	117-123
15794924-1	2005	Being key regulator of oxygen homeostasis hypoxia-inducible factor 1 (HIF-1) plays significant roles in cancer progression as well as in cardiovascular diseases.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-68
15794924-1	2005	Being key regulator of oxygen homeostasis hypoxia-inducible factor 1 (HIF-1) plays significant roles in cancer progression as well as in cardiovascular diseases.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
15826202-0	2005	Cobalt(III) corroles as electrocatalysts for the reduction of dioxygen: reactivity of a monocorrole, biscorroles, and porphyrin-corrole dyads.	Oxygen	62-70	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	7-10
15812313-6	2005	Of the energy metabolism intermediates examined, pyruvate significantly reduced the death and production of reactive oxygen species in cells expressing mutant SOD1.	Oxygen	117-123	superoxide dismutase 1	Homo sapiens	159-163
15826202-1	2005	Three series of cobalt(III) corroles were tested as catalysts for the electroreduction of dioxygen to water.	Oxygen	90-98	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-26
15826202-6	2005	The cobalt(III) monocorrole (Me(4)Ph(5)Cor)Co also catalyzes the electroreduction of dioxygen at E(1/2) = 0.38 V with the final products being an approximate 50% mixture of H(2)O(2) and H(2)O.	Oxygen	85-93	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	11-14
15792492-7	2005	It is proposed that [CuL]+ most likely features I coordinated via the deprotonated carboxylic acid group (O1) and the endocyclic oxygen atom (OR) forming a five-membered chelate ring.	Oxygen	129-135	cullin 2	Homo sapiens	21-24
15884375-7	2005	The oxygen flux was negative (consumption) at a rate of -4.9+/-0.5 nmoles cm(-2) min(-1) O2.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
15884375-7	2005	The oxygen flux was negative (consumption) at a rate of -4.9+/-0.5 nmoles cm(-2) min(-1) O2.	Oxygen	89-91	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
15653678-1	2005	The hypoxia-inducible factors 1alpha (HIF-1alpha) and 2alpha (HIF-2alpha) are key regulators of the transcriptional response to low oxygen and are closely related in domain architecture, DNA binding, and activation mechanisms.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-60
15819984-3	2005	This led us to suspect that reduction of IGF-1R levels in lung tissue could prevent deleterious effects of oxygen exposure.	Oxygen	107-113	insulin-like growth factor I receptor	Mus musculus	41-47
15819984-6	2005	RESULTS: Strikingly, after 72 h of exposure to 90% O2, IGF-1Rneo/- mice had a significantly better survival rate during recovery than IGF-1R+/+ mice (77% versus 53%, P &lt; 0.05).	Oxygen	51-53	insulin-like growth factor I receptor	Mus musculus	55-61
15808915-8	2005	Under hypoxic conditions (1% O2), expression of both adrenomedullin and endothelin-1 was induced in these cells.	Oxygen	29-31	endothelin 1	Homo sapiens	72-84
15833847-8	2005	Taken together, these findings indicate that additional molecular events are triggered by anoxia in a HIF-1-independent manner, and these changes are necessary for cell death observed in low-oxygen environments.	Oxygen	191-197	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-107
15792446-1	2005	A novel linear trinuclear mu-O-bridging 2-phosphinophenolate nickel(II) complex with fac-tris(P(intersection)O- chelates) in the terminal positions and the three oxygen atoms each facing the central nickel(II) cation was synthesized and structurally characterized by X-ray crystallography.	Oxygen	162-168	FA complementation group C	Homo sapiens	85-88
15625598-3	2005	Despite excellent vasopressive effects, vasopressin analogues may potentially impair macro-hemodynamics, oxygen transport and microvascular blood flow.	Oxygen	105-111	arginine vasopressin	Homo sapiens	40-51
15805316-2	2005	The authors studied the role of complement C5 in the development of abnormal oxygen kinetics during sepsis in mice, arguing that as a pro-inflammatory event, complement activation might exacerbate disturbances in oxygen use during abdominal sepsis.	Oxygen	77-83	hemolytic complement	Mus musculus	32-45
15805316-2	2005	The authors studied the role of complement C5 in the development of abnormal oxygen kinetics during sepsis in mice, arguing that as a pro-inflammatory event, complement activation might exacerbate disturbances in oxygen use during abdominal sepsis.	Oxygen	213-219	hemolytic complement	Mus musculus	32-45
15591411-6	2005	Rac1 and RhoA rapidly respond to changes in oxygen tension, and their activity depends on NADPH oxidase- and PI3 kinase-dependent production of ROS.	Oxygen	44-50	ras homolog family member A	Homo sapiens	9-13
15625598-5	2005	This review article discusses the results of clinical and experimental studies to judge the effects of vasopressin and terlipressin on microcirculation, oxygen supply, metabolism and organ function in patients with sepsis or systemic inflammatory response syndrome (SIRS).	Oxygen	153-159	arginine vasopressin	Homo sapiens	103-114
15871240-7	2005	Roots deliver oxygen, which oxidizes lead-bearing solid phases and releases Pb(II) to the sediment pore water.	Oxygen	14-20	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-82
15814637-1	2005	Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15814637-1	2005	Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15752713-1	2005	Cytochrome c (cyto-c) added to isolated mitochondria promotes the oxidation of extra-mitochondrial NADH and the reduction of molecular oxygen associated to the generation of an electrochemical membrane potential available for ATP synthesis.	Oxygen	135-141	cytochrome c, somatic	Homo sapiens	0-12
15752713-1	2005	Cytochrome c (cyto-c) added to isolated mitochondria promotes the oxidation of extra-mitochondrial NADH and the reduction of molecular oxygen associated to the generation of an electrochemical membrane potential available for ATP synthesis.	Oxygen	135-141	cytochrome c, somatic	Homo sapiens	14-20
15755667-8	2005	The docking studies between SH and BSA showed that the position of the oxygen atom of the hydroxyl group of SH (O(12)) was in favor of a nucleophilic attack on carbon atom of the amide bond of a beta-sheet (C(34)) because the distance between O(12) and C(34) was 3.37A.	Oxygen	71-77	albumin	Homo sapiens	35-38
15803054-2	2005	We found that 4 h of mild hypoxia (5% O2) caused substantial necrosis of isolated rat aortae (measured as lactate dehydrogenase release) if inducible NO synthase (iNOS) had previously been induced by endotoxin plus interferon-gamma.	Oxygen	38-40	nitric oxide synthase 2	Rattus norvegicus	163-167
15728783-9	2005	Both allantoin, a marker of oxygen free radical generation, and reactive oxygen species increased significantly after EPO or NESP treatment compared with control.	Oxygen	28-34	GNAS complex locus	Homo sapiens	125-129
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	Oxygen	248-250	transcription factor Dp-1	Homo sapiens	86-89
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Oxygen	3-5	transcription factor Dp-1	Homo sapiens	24-27
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Oxygen	3-5	transcription factor Dp-1	Homo sapiens	158-161
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Oxygen	165-167	transcription factor Dp-1	Homo sapiens	24-27
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Oxygen	165-167	transcription factor Dp-1	Homo sapiens	158-161
15798192-4	2005	This adaptive mechanism is accompanied by initial inhibition of the myoD, E2A, and myogenin genes followed by resumption of their expression in an oxygen-dependent manner.	Oxygen	147-153	myogenic differentiation 1	Homo sapiens	68-72
16705796-2	2005	The post-translational modification of HIF-1a, the oxygen-sensitive subunit of HIF-1, regulates stabilization, nuclear translocation, DNA binding activity, and transcriptional activity of the protein.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-45
16705796-2	2005	The post-translational modification of HIF-1a, the oxygen-sensitive subunit of HIF-1, regulates stabilization, nuclear translocation, DNA binding activity, and transcriptional activity of the protein.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
15876406-0	2005	New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible?	Oxygen	126-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	99-115
15876406-8	2005	For aldosterone formation, dioxygen is bonded to C-11 and C-18 of an appropriate precursor.	Oxygen	27-35	Bardet-Biedl syndrome 9	Homo sapiens	58-62
15777842-3	2005	Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	Oxygen	215-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15739015-0	2005	Kinetics and mechanism of the Co(II)-assisted oxidation of thioureas by dioxygen.	Oxygen	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15966258-20	2005	The transcription factor hypoxia-inducible factor 1 (HIF-1) is a global regulator of oxygen homeostasis.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-51
15966258-20	2005	The transcription factor hypoxia-inducible factor 1 (HIF-1) is a global regulator of oxygen homeostasis.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
15781740-11	2005	There was a decrease in SOD2 protein level and a concomitant increase in lucigenin-detectable O2- production in skeletal muscle from SOD2+/-.	Oxygen	94-96	superoxide dismutase 2, mitochondrial	Mus musculus	133-137
15781740-12	2005	CONCLUSIONS: These results suggest that exercise capacity is reduced in conditions in which superoxide anion is increased, and this is associated with a greater increase in whole-body oxygen consumption in SOD2+/- compared with SOD2+/+.	Oxygen	184-190	superoxide dismutase 2, mitochondrial	Mus musculus	206-210
15767462-0	2005	Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-111
15694394-2	2005	In this report, we demonstrate the ability of the tricyclic antidepressant chlorimipramine to kill human glioma cells in vitro by a molecular mechanism resulting in an increase in caspase 3 activity following inhibition of glioma oxygen consumption.	Oxygen	230-236	caspase 3	Homo sapiens	180-189
15767462-3	2005	Low O(2) exposure blocked cytochrome c release after NGF withdrawal, in part by suppressing the up-regulation of BIM(EL).	Oxygen	4-8	cytochrome c, somatic	Homo sapiens	26-38
15767462-5	2005	Exposing neurons to low O(2) also activated hypoxia-inducible factor (HIF) and expression of a stabilized form of HIF-1alpha (HIF-1alpha(PP--&gt;AG)) inhibited cell death in normoxic, NGF-deprived cells.	Oxygen	24-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
15767462-5	2005	Exposing neurons to low O(2) also activated hypoxia-inducible factor (HIF) and expression of a stabilized form of HIF-1alpha (HIF-1alpha(PP--&gt;AG)) inhibited cell death in normoxic, NGF-deprived cells.	Oxygen	24-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
15767462-6	2005	Targeted deletion of HIF-1alpha partially suppressed the protective effect of low O(2), whereas deletion of HIF-1alpha combined with forced BIM(EL) expression completely reversed the ability of low O(2) to inhibit cell death.	Oxygen	198-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
15599750-8	2005	The increased Epo secretion may represent either a physiologic response to tissue hypoxia, an abnormal autonomous Epo production, or a dysregulation of the oxygen-dependent Epo synthesis.	Oxygen	156-162	erythropoietin	Homo sapiens	14-17
15592883-0	2005	Changes of local brain tissue oxygen pressure after vasopressin during spontaneous circulation.	Oxygen	30-36	arginine vasopressin	Homo sapiens	52-63
15618010-2	2005	Hypoxia-inducible factor 1 (HIF-1) is the major oxygen homeostasis regulator.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15790116-5	2005	This electrode was successfully applied as an indicator electrode in the potentiometric titration of ascorbic acid and hydroquinone from pharmaceutical preparations as well as ascorbic acid in orange juice and dissolved O2 in tap water.	Oxygen	220-222	SEC14 like lipid binding 2	Homo sapiens	226-229
15826412-7	2005	The relevance of these findings to free flap oxygen consumption and to the delay phenomenon is discussed.	Oxygen	45-51	arachidonate 5-lipoxygenase activating protein	Homo sapiens	40-44
15777089-2	2005	Low temperature direct ESR revealed that cysteine (Cys) caused the reduction of copper(II) to copper(I) that was reoxidized by molecular oxygen to copper(II) at the active site of SOD1.	Oxygen	137-143	superoxide dismutase 1	Homo sapiens	180-184
15731028-0	2005	Susceptibility of germfree phagocyte oxidase- and nitric oxide synthase 2-deficient mice, defective in the production of reactive metabolites of both oxygen and nitrogen, to mucosal and systemic candidiasis of endogenous origin.	Oxygen	150-156	nitric oxide synthase 2, inducible	Mus musculus	50-73
15618548-2	2005	METHODS AND RESULTS: Electroporation of anti-p47phox antibody into VSMCs abrogated Ang II-mediated O2 generation, establishing the requirement for p47phox in this response.	Oxygen	99-101	angiotensinogen	Homo sapiens	83-89
15708569-0	2005	Attenuation of retinal vascular development and neovascularization during oxygen-induced ischemic retinopathy in Bcl-2-/- mice.	Oxygen	74-80	B cell leukemia/lymphoma 2	Mus musculus	113-118
15708569-4	2005	In this study, we investigated the physiological role of bcl-2 in development of retinal vasculature and retinal neovascularization during oxygen-induced ischemic retinopathy (OIR).	Oxygen	139-145	B cell leukemia/lymphoma 2	Mus musculus	57-62
16004298-8	2005	Oxygen promotes CS2 photooxidation.	Oxygen	0-6	chorionic somatomammotropin hormone 2	Homo sapiens	16-19
15618010-2	2005	Hypoxia-inducible factor 1 (HIF-1) is the major oxygen homeostasis regulator.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15618010-4	2005	However, under hypoxic conditions, HIF-1 is stabilized and permits the activation of genes essential to cellular adaptation to low oxygen conditions.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
15598682-3	2005	The present study was designed to investigate the effect of low-oxygen conditions on RhoA expression in trophoblast cells isolated from early stages of human placenta and in trophoblast-derived BeWo cells and JAR cells.	Oxygen	64-70	ras homolog family member A	Homo sapiens	85-89
15598682-4	2005	Immunoblot and RT-PCR analyses showed that low-oxygen conditions (1% O(2) or 250 mum CoCl(2)) stimulated expression of RhoA protein and mRNA.	Oxygen	47-53	ras homolog family member A	Homo sapiens	119-123
15598682-4	2005	Immunoblot and RT-PCR analyses showed that low-oxygen conditions (1% O(2) or 250 mum CoCl(2)) stimulated expression of RhoA protein and mRNA.	Oxygen	69-73	ras homolog family member A	Homo sapiens	119-123
15598682-5	2005	Pull-down assays demonstrated that these low-oxygen conditions increased RhoA activity.	Oxygen	45-51	ras homolog family member A	Homo sapiens	73-77
15598682-7	2005	Under 1% O(2) or 250 mum CoCl(2), BeWo cells, transfected with a dominant-negative RhoA, exhibited decreased levels of HIF-1alpha protein and mRNA compared with the control vector transfectants.	Oxygen	9-13	ras homolog family member A	Homo sapiens	83-87
15598682-7	2005	Under 1% O(2) or 250 mum CoCl(2), BeWo cells, transfected with a dominant-negative RhoA, exhibited decreased levels of HIF-1alpha protein and mRNA compared with the control vector transfectants.	Oxygen	9-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
15598682-9	2005	These findings suggest that up-regulation of RhoA induced by low-oxygen conditions may play an important role in regulation of HIF-1alpha expression in trophoblast cells.	Oxygen	65-71	ras homolog family member A	Homo sapiens	45-49
15598682-9	2005	These findings suggest that up-regulation of RhoA induced by low-oxygen conditions may play an important role in regulation of HIF-1alpha expression in trophoblast cells.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
15678512-8	2005	In acute hippocampal slices maintained on nonvascular supplies of glucose and oxygen, ET-1 significantly decreased the distance traveled along the Schaffer collateral tract by nonmetabolically-labeled lipid rafts at 5 and 10 min after pulse-labeling.	Oxygen	78-84	endothelin 1	Rattus norvegicus	86-90
15590888-6	2005	Co-cultures exposed to these physiologic oxygen gradients demonstrated regionally heterogeneity of CYP2B and CYP3A protein that mimics the distribution seen in the zonated liver.	Oxygen	41-47	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	109-114
15752200-4	2005	SOD2 deletion rendered Cn highly growth-defective at 37 degrees C in 19-20% oxygen (normal air), and this defect was reversed by limiting oxygen to 1.3% as well in the presence of antioxidant, ascorbic acid.	Oxygen	76-82	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
15752200-4	2005	SOD2 deletion rendered Cn highly growth-defective at 37 degrees C in 19-20% oxygen (normal air), and this defect was reversed by limiting oxygen to 1.3% as well in the presence of antioxidant, ascorbic acid.	Oxygen	138-144	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
15752200-8	2005	The virulence defect of sod2 mutant appeared related to its growth defects in high oxygen environment, but not resulting from increased sensitivity to oxidative killing by phagocytes.	Oxygen	83-89	superoxide dismutase 2, mitochondrial	Mus musculus	24-28
15635051-6	2005	VEGF -460TT/+405CC haplotype was more prevalent in the treated patients than in the untreated patients (13 of 86 versus 1 of 115; p &lt;0.001), and the association remained significant (p &lt;0.01) even after the adjustment for risk factors of ROP (gestational age, supplemental oxygen therapy, and gender).	Oxygen	279-285	vascular endothelial growth factor A	Homo sapiens	0-4
15743827-7	2005	TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron.	Oxygen	175-177	mitogen-activated protein kinase 1	Homo sapiens	67-113
15743827-7	2005	TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron.	Oxygen	175-177	mitogen-activated protein kinase 3	Homo sapiens	115-121
15743827-7	2005	TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron.	Oxygen	175-177	mitogen-activated protein kinase 1	Homo sapiens	127-130
15664123-0	2005	Inhibitors of iNOS protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.	Oxygen	72-78	nitric oxide synthase 2	Rattus norvegicus	14-18
15762917-2	2005	Several CPR studies in pigs showed that vasopressin improved blood flow to vital organs, cerebral oxygen delivery, resuscitability and neurological outcome when compared with epinephrine.	Oxygen	98-104	vasopressin	Sus scrofa	40-51
15743620-8	2005	The rapid removal of As(III) and As(V) was caused by adsorption on ferric hydroxides formed readily through oxidation of Fe(0) by dissolved oxygen.	Oxygen	140-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
15721249-1	2005	In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).	Oxygen	124-126	OS9 endoplasmic reticulum lectin	Homo sapiens	64-68
15770062-7	2005	Ozone/oxygen gaseous mixture reduced serum TNF-alpha levels in a dose-dependent manner.	Oxygen	6-12	tumor necrosis factor	Mus musculus	43-52
15716413-0	2005	NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.	Oxygen	31-37	amyloid beta precursor protein	Homo sapiens	101-113
15721249-1	2005	In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).	Oxygen	124-126	OS9 endoplasmic reticulum lectin	Homo sapiens	254-258
15721254-7	2005	These data indicate that OS-9 is an essential component of a multiprotein complex that regulates HIF-1alpha levels in an O2-dependent manner.	Oxygen	121-123	OS9 endoplasmic reticulum lectin	Homo sapiens	25-29
15721254-7	2005	These data indicate that OS-9 is an essential component of a multiprotein complex that regulates HIF-1alpha levels in an O2-dependent manner.	Oxygen	121-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
15721254-0	2005	OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.	Oxygen	87-93	OS9 endoplasmic reticulum lectin	Homo sapiens	0-4
15721254-0	2005	OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
15721254-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15721254-1	2005	Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15721254-3	2005	The half-life of the HIF-1alpha subunit is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
15721254-3	2005	The half-life of the HIF-1alpha subunit is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
15557328-5	2005	Here, we show that in superoxide dismutase 1 (SOD1) knock-out mice, lacking Cu,Zn-SOD, an enzyme that acts to reduce the concentration of O2*- mainly in cytosol, not only is aconitase activity of IRP1 inhibited but the level of IRP1 is also strongly decreased.	Oxygen	138-140	superoxide dismutase 1, soluble	Mus musculus	22-44
15635607-7	2005	These results raise the possibility that NPAS1 plays a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.	Oxygen	156-162	neuronal PAS domain protein 1	Homo sapiens	41-46
15635607-7	2005	These results raise the possibility that NPAS1 plays a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.	Oxygen	156-162	erythropoietin	Homo sapiens	117-120
15557328-5	2005	Here, we show that in superoxide dismutase 1 (SOD1) knock-out mice, lacking Cu,Zn-SOD, an enzyme that acts to reduce the concentration of O2*- mainly in cytosol, not only is aconitase activity of IRP1 inhibited but the level of IRP1 is also strongly decreased.	Oxygen	138-140	superoxide dismutase 1, soluble	Mus musculus	46-50
15557328-5	2005	Here, we show that in superoxide dismutase 1 (SOD1) knock-out mice, lacking Cu,Zn-SOD, an enzyme that acts to reduce the concentration of O2*- mainly in cytosol, not only is aconitase activity of IRP1 inhibited but the level of IRP1 is also strongly decreased.	Oxygen	138-140	superoxide dismutase 1, soluble	Mus musculus	76-85
15681845-1	2005	The present study was undertaken to test whether inhibition of the proangiogenic inflammatory cytokine tumor necrosis factor (TNF)-alpha can modulate retinal hypoxia and preretinal neovascularization in a murine model of oxygen-induced retinopathy (OIR).	Oxygen	221-227	tumor necrosis factor	Mus musculus	103-136
15683237-9	2005	Surprisingly, cytochrome c is about a 100-fold better electron acceptor for ALR than oxygen when DTT is the reducing substrate.	Oxygen	85-91	cytochrome c, somatic	Homo sapiens	14-26
15675840-3	2005	For example, 2-amino-1-butanol, 6a, was treated with 1 to get the N,O-diPoc compound 7a in 90% yield, which when treated with 1.1 equiv of 2 at room temperature removes the Poc group attached to oxygen while leaving the one attached to nitrogen intact to yield compound 8a in 85% yield.	Oxygen	195-201	proopiomelanocortin	Homo sapiens	72-75
15629108-0	2005	Reaction of ferrous lactoperoxidase with hydrogen peroxide and dioxygen: an anaerobic stopped-flow study.	Oxygen	63-71	lactoperoxidase	Homo sapiens	20-35
15629108-3	2005	The present anaerobic stopped-flow kinetic analysis was performed in order to elucidate the catalytic mechanism of LPO and the kinetics of compound III formation by probing the reactivity of ferrous LPO with hydrogen peroxide and molecular oxygen.	Oxygen	240-246	lactoperoxidase	Homo sapiens	115-118
15629108-6	2005	Alternatively, compound III is also formed by dioxygen binding to ferrous LPO at an apparent bimolecular rate constant of (1.8+/-0.2) x 10(5) M(-1) s(-1).	Oxygen	46-54	lactoperoxidase	Homo sapiens	74-77
15629108-8	2005	The rate constant of dioxygen dissociation from compound III is higher than conversion of compound III to ferric LPO, which is not affected by the oxygen concentration and follows a biphasic kinetics.	Oxygen	21-29	lactoperoxidase	Homo sapiens	113-116
15629108-8	2005	The rate constant of dioxygen dissociation from compound III is higher than conversion of compound III to ferric LPO, which is not affected by the oxygen concentration and follows a biphasic kinetics.	Oxygen	23-29	lactoperoxidase	Homo sapiens	113-116
15667229-1	2005	Human cytochrome P450 (CYP) 3A4 catalyzes the oxygen-dependent metabolism of greater than 60% of known drugs.	Oxygen	46-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-31
16040352-5	2005	The role of ACO5 in the low oxygen response of tomato is discussed.	Oxygen	28-34	1-aminocyclopropane-1-carboxylate oxidase	Solanum lycopersicum	12-16
15679808-1	2005	OBJECTIVES: To investigate the possible role of hypoxia-inducible factor 1alpha (HIF-1alpha, a transcription factor important in regulating O(2) homeostasis and physiological responses to oxygen deprivation) in the recurrence and progression of superficial urothelial bladder cancer, and to examine its expression in relation to proliferation status, apoptotic activity and intratumoral angiogenesis.	Oxygen	140-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-79
15679808-1	2005	OBJECTIVES: To investigate the possible role of hypoxia-inducible factor 1alpha (HIF-1alpha, a transcription factor important in regulating O(2) homeostasis and physiological responses to oxygen deprivation) in the recurrence and progression of superficial urothelial bladder cancer, and to examine its expression in relation to proliferation status, apoptotic activity and intratumoral angiogenesis.	Oxygen	140-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
15679808-1	2005	OBJECTIVES: To investigate the possible role of hypoxia-inducible factor 1alpha (HIF-1alpha, a transcription factor important in regulating O(2) homeostasis and physiological responses to oxygen deprivation) in the recurrence and progression of superficial urothelial bladder cancer, and to examine its expression in relation to proliferation status, apoptotic activity and intratumoral angiogenesis.	Oxygen	188-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-79
15679808-1	2005	OBJECTIVES: To investigate the possible role of hypoxia-inducible factor 1alpha (HIF-1alpha, a transcription factor important in regulating O(2) homeostasis and physiological responses to oxygen deprivation) in the recurrence and progression of superficial urothelial bladder cancer, and to examine its expression in relation to proliferation status, apoptotic activity and intratumoral angiogenesis.	Oxygen	188-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
15749641-1	2005	Hypoxia-inducible factor-1 is a heterodimer made up of an oxygen-regulated HIF1alpha subunit and a constitutively expressed HIF1beta subunit.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-84
15792365-3	2005	We analyzed the expression of the hypoxia-inducible factor-1alpha (HIF-1alpha) under different hypoxic conditions (3% and nearly 0% O2) and Co2+ -concentrations (0.01-0.7 mM).	Oxygen	132-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-65
15501927-5	2005	We found that exposure of serum-starved fibroblasts to 3% O2 resulted in a time-dependent activation of PI3K and transient phosphorylation of Akt.	Oxygen	58-60	AKT serine/threonine kinase 1	Homo sapiens	142-145
15694772-1	2005	The calcium-dependent interaction of calmodulin and melittin is studied through the application of a radical probe approach in which solutions of the protein and peptide and protein alone are subjected to high fluxes of hydroxyl and other oxygen radicals on millisecond timescales.	Oxygen	239-245	calmodulin 1	Homo sapiens	37-47
15792365-3	2005	We analyzed the expression of the hypoxia-inducible factor-1alpha (HIF-1alpha) under different hypoxic conditions (3% and nearly 0% O2) and Co2+ -concentrations (0.01-0.7 mM).	Oxygen	132-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
15516695-1	2005	Heme oxygenase-1 (HO-1) catalyzes the physiological degradation of heme at the expense of molecular oxygen using electrons donated by NADPH-cytochrome P450 reductase (CPR).	Oxygen	5-11	cytochrome p450 oxidoreductase	Homo sapiens	134-165
15680278-7	2005	The results demonstrated that increases in plasma TNF-alpha and NO, and the vasohyporeactivity induced by lipopolysaccharide treatment were significantly inhibited by hyperbaric oxygen and aminoguanidine.	Oxygen	178-184	tumor necrosis factor	Rattus norvegicus	50-59
15663790-11	2005	CONCLUSION: In the initiation phase of pulmonary oxygen toxicity, an increase of TNFalpha and its receptor TNFR1 leads to the activation of caspase 8 and 3 in TIIcells.	Oxygen	49-55	tumor necrosis factor	Rattus norvegicus	81-89
15695405-1	2005	Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15695405-1	2005	Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15509579-8	2005	Partial inactivation of MTU1 in HeLa cells by small interference RNA also reduced their oxygen consumption and resulted in mitochondria with defective membrane potentials, which are similar phenotypic features observed in MERRF.	Oxygen	88-94	tRNA mitochondrial 2-thiouridylase	Homo sapiens	24-28
15631446-3	2005	The artificially created domain worked as a barrier against exogenous ligand penetration into the heme pocket, whereas the bound O2 was stabilized in the reconstituted myoglobin as well as in the native one.	Oxygen	129-131	myoglobin	Equus caballus	168-177
15631446-5	2005	As a result, the substantial ligand selectivity for the reconstituted myoglobin significantly increases in favor of O2 over CO with the M" value (= KCO/KO2) of 0.88, whereas, to the best of our knowledge, there is no myoglobin mutant in which the O2 affinity exceeds the CO one.	Oxygen	116-118	myoglobin	Equus caballus	70-79
15631446-5	2005	As a result, the substantial ligand selectivity for the reconstituted myoglobin significantly increases in favor of O2 over CO with the M" value (= KCO/KO2) of 0.88, whereas, to the best of our knowledge, there is no myoglobin mutant in which the O2 affinity exceeds the CO one.	Oxygen	116-118	myoglobin	Equus caballus	217-226
15631446-5	2005	As a result, the substantial ligand selectivity for the reconstituted myoglobin significantly increases in favor of O2 over CO with the M" value (= KCO/KO2) of 0.88, whereas, to the best of our knowledge, there is no myoglobin mutant in which the O2 affinity exceeds the CO one.	Oxygen	153-155	myoglobin	Equus caballus	70-79
15631446-6	2005	The present work concludes that the O2 selectivity of myoglobin over CO is markedly improved by chemically modifying the heme propionates without any mutation of the amino acid residues in the distal site.	Oxygen	36-38	myoglobin	Equus caballus	54-63
15516695-1	2005	Heme oxygenase-1 (HO-1) catalyzes the physiological degradation of heme at the expense of molecular oxygen using electrons donated by NADPH-cytochrome P450 reductase (CPR).	Oxygen	5-11	cytochrome p450 oxidoreductase	Homo sapiens	167-170
15629713-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that plays a crucial role in mediating oxygen response in the cell.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15799568-1	2005	CONCLUSION: As we demonstrated previously that transcription of alpha-ENaC was correlated with oxygen tension in the culture medium, this study suggests that the increase in alpha-ENaC expression observed under ALI conditions may result from greater oxygenation of ME cells.	Oxygen	95-101	sodium channel epithelial 1 subunit alpha	Homo sapiens	64-74
15629713-1	2005	Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that plays a crucial role in mediating oxygen response in the cell.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15581571-3	2005	HPPD is a member of the alpha-keto acid dependent oxygenases that typically require an alpha-keto acid (almost exclusively alpha-ketoglutarate) and molecular oxygen to either oxygenate or oxidize a third molecule.	Oxygen	50-56	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	0-4
15622543-7	2005	Mice deficient in IL-1 receptor-associated kinase 4 (IRAK-4), which is pivotal for both IL-1beta and IL-18 signal transduction, were protected against oxygen-mediated neurotoxicity.	Oxygen	151-157	interleukin 1 beta	Mus musculus	88-96
15607903-8	2005	In addition, (bi)carbonate enhanced H2O2-induced SOD1 turnover as demonstrated by an enhancement in oxygen evolution and SOD1 inactivation.	Oxygen	100-106	superoxide dismutase 1	Homo sapiens	49-53
15615775-1	2005	The hypoxia-inducible factor-1 (HIF-1) is a key regulator of oxygen homeostasis in the cell.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
15615775-1	2005	The hypoxia-inducible factor-1 (HIF-1) is a key regulator of oxygen homeostasis in the cell.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
15622543-3	2005	We hypothesized that two caspase-1-processed cytokines, interleukin (IL)-1beta and IL-18, are involved in oxygen-induced neuronal cell death.	Oxygen	106-112	caspase 1	Homo sapiens	25-34
15622543-3	2005	We hypothesized that two caspase-1-processed cytokines, interleukin (IL)-1beta and IL-18, are involved in oxygen-induced neuronal cell death.	Oxygen	106-112	interleukin 1 beta	Homo sapiens	56-78
15581571-4	2005	As an exception in this class of enzymes HPPD has only two substrates, does not use alpha-ketoglutarate, and incorporates both atoms of dioxygen into the aromatic product, homogentisate.	Oxygen	136-144	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	41-45
16392333-6	2005	Impairment of the myeloperoxidase- and NADPH-depended production of active oxygen by non-activated and activated neutrophils observed before operations resulted in altered synthesis of active oxygen after the surgery.	Oxygen	75-81	myeloperoxidase	Homo sapiens	18-33
16392333-6	2005	Impairment of the myeloperoxidase- and NADPH-depended production of active oxygen by non-activated and activated neutrophils observed before operations resulted in altered synthesis of active oxygen after the surgery.	Oxygen	192-198	myeloperoxidase	Homo sapiens	18-33
16392333-8	2005	Detection of the myeloperoxidase- and NADPH-depended production of active oxygen could be of help in revealing the groups of risk among patients at the stage of the preoperative examination and serve as a prognostic factor of the development of severe infectious complications during the postoperative period.	Oxygen	74-80	myeloperoxidase	Homo sapiens	17-32
15987491-2	2005	Binding of immune complexes (ICs) to FcgammaRI leads to the prominent production of oxygen radicals.	Oxygen	84-90	Fc receptor, IgG, high affinity I	Mus musculus	37-46
15585204-8	2005	Furthermore hypoxia (&lt; or =1% O2) as a further proinflammatory and especially proangiogenetic factor was able to stimulate MIF secretion by THP-1, human monocytes and HUVECs.	Oxygen	33-35	GLI family zinc finger 2	Homo sapiens	143-148
15987493-1	2005	Transcription factor hypoxia-inducible factor (HIF)-1 protein accumulates and activates the transcription of genes that are of fundamental importance for oxygen homeostasis - including genes involved in energy metabolism, angiogenesis, vasomotor control, apoptosis, proliferation, and matrix production - under hypoxic conditions.	Oxygen	154-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-53
16015032-11	2005	Plasma fibrinogen was correlated with nocturnal minimal oxygen saturation (r=-0275, p=0.0036) and AHI (r=0.297, p=0.001).	Oxygen	56-62	fibrinogen beta chain	Homo sapiens	7-17
15745143-12	2005	The inverse relationship of both cerebral and renal markers with DO2 and VO2 suggests that increased levels of S100beta and NAG during CPB may primarily be caused by an oxygen deficit and secondary to the inflammatory response.	Oxygen	169-175	S100 calcium binding protein B	Homo sapiens	111-119
15745143-10	2005	After protamine infusion, total body oxygen delivery and consumption correlated negatively with S100beta levels (both p &lt; 0.05) and with NAG levels (both p &lt; 0.01).	Oxygen	37-43	S100 calcium binding protein B	Homo sapiens	96-104
15656571-0	2005	Human serum albumin bearing covalently attached iron(II) porphyrins as O2-coordination sites.	Oxygen	71-73	albumin	Homo sapiens	6-19
16041620-1	2005	The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-36
16041620-3	2005	The destruction of HIF-1alpha in the presence of oxygen is initiated by prolyl-4-hydroxylation.	Oxygen	49-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
15665520-2	2005	With respect to O2 deprivation, the hypoxia-inducible factor 1alpha/ beta (HIF-1) is the most important transcription factor driving VEGF mRNA expression.	Oxygen	16-18	vascular endothelial growth factor A	Homo sapiens	133-137
15232594-2	2005	We examined whether an increase in the naturally occurring enzyme copper-zinc superoxide dismutase (CuZnSOD), which controls oxygen, can reduce the severity of oxygen-induced retinopathy in a mouse model.	Oxygen	125-131	superoxide dismutase 1, soluble	Mus musculus	100-107
15809210-0	2005	The association of the carrier state of the tumor necrosis factor-alpha (TNFalpha) -308A allele with the duration of oxygen supplementation in preterm neonates.	Oxygen	117-123	tumor necrosis factor	Homo sapiens	44-71
15809210-0	2005	The association of the carrier state of the tumor necrosis factor-alpha (TNFalpha) -308A allele with the duration of oxygen supplementation in preterm neonates.	Oxygen	117-123	tumor necrosis factor	Homo sapiens	73-81
15809210-6	2005	RESULTS: The carrier state of the TNF-alpha G(-308)A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on average, an additional 36 hours of oxygen supplementation (p=0.0008).	Oxygen	183-189	tumor necrosis factor	Homo sapiens	34-43
15809210-8	2005	CONCLUSIONS: The TNF-alpha G(308)A genotype - which is associated with increased TNF-alpha levels - might influence the supplemental oxygen requirement of VLBW infants.	Oxygen	133-139	tumor necrosis factor	Homo sapiens	17-26
15809210-8	2005	CONCLUSIONS: The TNF-alpha G(308)A genotype - which is associated with increased TNF-alpha levels - might influence the supplemental oxygen requirement of VLBW infants.	Oxygen	133-139	tumor necrosis factor	Homo sapiens	81-90
15809211-6	2005	Amongst the hypoxic infants, the number of days of oxygen supplementation correlated positively with early IL-10 levels (p=0.009; r=0.495) and negatively with the IFN-gamma/IL-10 ratio (p=0.007; r=0.495).	Oxygen	51-57	interferon gamma	Homo sapiens	163-172
15665520-2	2005	With respect to O2 deprivation, the hypoxia-inducible factor 1alpha/ beta (HIF-1) is the most important transcription factor driving VEGF mRNA expression.	Oxygen	16-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-73
15665520-2	2005	With respect to O2 deprivation, the hypoxia-inducible factor 1alpha/ beta (HIF-1) is the most important transcription factor driving VEGF mRNA expression.	Oxygen	16-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-80
16305531-6	2005	Key structural features determining A3AR interaction include the N6-benzyl group, 2-position substitution such as halo, substitution of ribose (e.g., the (N)-methanocarba ring system, various 2"- and 3"-substitutions and 4"-thio substitution of oxygen).	Oxygen	245-251	adenosine A3 receptor	Homo sapiens	36-40
15617478-4	2005	Prolyl and asparaginyl hydroxylases as recently characterized oxygen sensors allow the regulation of HIFs that in turn modulate expression of hypoxically regulated genes such as VEGF.	Oxygen	62-68	vascular endothelial growth factor A	Homo sapiens	178-182
15232594-2	2005	We examined whether an increase in the naturally occurring enzyme copper-zinc superoxide dismutase (CuZnSOD), which controls oxygen, can reduce the severity of oxygen-induced retinopathy in a mouse model.	Oxygen	160-166	superoxide dismutase 1, soluble	Mus musculus	100-107
15232594-10	2005	CONCLUSIONS: The results suggest that high SOD activity protects neonatal mice against oxygen-induced retinopathy, and support the assumption that oxygen radicals are a major causative factor in oxygen-induced retinopathy.	Oxygen	87-93	superoxide dismutase 1, soluble	Mus musculus	43-46
15658785-10	2005	By altering the properties of the incorporated hydrophobic group, liposomes able to fuse in response to initiators milder than UV light, such as green or red light, sound, temperature, oxygen or pH can be engineered.	Oxygen	185-191	Polykaryocytosis inducer	Homo sapiens	84-88
15232594-10	2005	CONCLUSIONS: The results suggest that high SOD activity protects neonatal mice against oxygen-induced retinopathy, and support the assumption that oxygen radicals are a major causative factor in oxygen-induced retinopathy.	Oxygen	147-153	superoxide dismutase 1, soluble	Mus musculus	43-46
15742531-4	2005	Lower P50 with increased Hb-O2 affinity induced by low 2,3-BPG is a characteristic of hibernating species and could be advantageous in O2-impoverished environments.	Oxygen	28-30	nuclear factor kappa B subunit 1	Homo sapiens	6-9
15574355-8	2005	A three-dimensional model of CYP27B1 structure simulated on the basis of the crystal structure of rabbit CYP2C5 supports the experimental data from mutagenesis study of CYP27B1 that the mutated amino acid residues may be involved in protein folding, heme-propionate binding or activation of molecular oxygen.	Oxygen	301-307	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-36
15574355-8	2005	A three-dimensional model of CYP27B1 structure simulated on the basis of the crystal structure of rabbit CYP2C5 supports the experimental data from mutagenesis study of CYP27B1 that the mutated amino acid residues may be involved in protein folding, heme-propionate binding or activation of molecular oxygen.	Oxygen	301-307	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	169-176
15849721-3	2005	The enzyme activity of aryl sulfotransferase IV increased 3- to 8-fold in &gt;95% O2 treated rat lungs.	Oxygen	82-84	sulfotransferase family 1A member 1	Rattus norvegicus	23-47
16052887-3	2005	In normal cells, oxygen derivatives are neutralized or eliminated owing to the presence of a natural defense mechanism that involves enzymatic antioxidants (glutathione peroxidase, superoxide dismutase, catalase) and water or fat-soluble non-enzymatic antioxidants (vitamins C and E, glutathione, selenium).	Oxygen	17-23	catalase	Homo sapiens	203-211
15486012-4	2005	It has recently been reported that TREK-1 channels are also affected by oxygen concentrations, and that at the levels of hypoxia that occur in the normal human brain, the channels greatly change their properties and, for example, lose their ability to be modulated by arachidonic acid and internal acidosis.	Oxygen	72-78	potassium two pore domain channel subfamily K member 2	Homo sapiens	35-41
15804045-4	2005	The aim of this study was to assess the influence of in vivo TNF blockade on oxygen burst (OB) and phagocytosis of human neutrophils.	Oxygen	77-83	tumor necrosis factor	Homo sapiens	61-64
15586242-1	2005	Hypoxia-inducible factor-1 (HIF-1) is one of the key mammalian transcription factors and shows increased levels in both protein stability and intrinsic transcriptional activity during low oxygen tension.	Oxygen	188-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15586242-1	2005	Hypoxia-inducible factor-1 (HIF-1) is one of the key mammalian transcription factors and shows increased levels in both protein stability and intrinsic transcriptional activity during low oxygen tension.	Oxygen	188-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15674517-3	2005	One of the most important transcription factors that activate the expression of oxygen-regulated genes is hypoxia-inducible factor 1 (HIF-1).	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-132
15674517-3	2005	One of the most important transcription factors that activate the expression of oxygen-regulated genes is hypoxia-inducible factor 1 (HIF-1).	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
16201271-2	2005	The expression of hypoxia inducible factor-1 alpha, P-gp and mutltidrug resistance protein was immunohistochemically detected by culturing human lung adenocarcinoma A549 cell under hypoxia (2 % O2) for 24 h. After interaction with adriamycin or cisplatin under hypoxia (2 % O2) for 24 h, the cell survival rate was detected by MTT.	Oxygen	194-196	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
16113471-1	2005	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15754761-7	2005	Suppression of EC-SOD production in growth medium along with MC proliferation and chemokine hyper-production compared with production in differentiation medium might mimic reduction of the protective capacity against oxygen radical toxity during mesangial proliferation in the glomerular nephritis.	Oxygen	217-223	superoxide dismutase 3	Homo sapiens	15-21
15754761-8	2005	MC proliferation with type I collagen and fibronectin might enhance oxygen radical toxity in the glomeruli, and accelerate glomerular sclerosis through the suppression of EC-SOD production.	Oxygen	68-74	fibronectin 1	Homo sapiens	42-53
16291246-1	2005	Macrophages serve as the first-line defense against invading pathogens by (a) overproducing O2- via activation of NADPH-oxidase localized in its plasma membrane, (b) inducing the expression of inducible nitric oxide synthase (iNOS) and overproducing NO, and (c) generating highly toxic peroxynitrite (ONOO-) to kill the invading pathogens without killing the macrophages themselves.	Oxygen	92-94	nitric oxide synthase 2	Homo sapiens	193-224
16291246-1	2005	Macrophages serve as the first-line defense against invading pathogens by (a) overproducing O2- via activation of NADPH-oxidase localized in its plasma membrane, (b) inducing the expression of inducible nitric oxide synthase (iNOS) and overproducing NO, and (c) generating highly toxic peroxynitrite (ONOO-) to kill the invading pathogens without killing the macrophages themselves.	Oxygen	92-94	nitric oxide synthase 2	Homo sapiens	226-230
16291246-4	2005	Thus, the NO overproduced by the O2- -dependent induction of iNOS expression can scavenge O2- to produce ONOO-, first to kill the invading pathogens and second to enhance the HO-1 expression in macrophages.	Oxygen	33-35	nitric oxide synthase 2	Homo sapiens	61-65
16291246-4	2005	Thus, the NO overproduced by the O2- -dependent induction of iNOS expression can scavenge O2- to produce ONOO-, first to kill the invading pathogens and second to enhance the HO-1 expression in macrophages.	Oxygen	90-92	nitric oxide synthase 2	Homo sapiens	61-65
15567517-0	2005	Role of Bcl-2 family of proteins in mediating apoptotic death of PC12 cells exposed to oxygen and glucose deprivation.	Oxygen	87-93	BCL2, apoptosis regulator	Rattus norvegicus	8-13
15567517-3	2005	We have examined the role of Bcl-2 family of proteins in mediating apoptosis of PC12 cells exposed to the conditions of oxygen and glucose deprivation (OGD) or OGD followed by restoration of oxygen and glucose (OGD-restoration, OGD-R).	Oxygen	120-126	BCL2, apoptosis regulator	Rattus norvegicus	29-34
15567517-3	2005	We have examined the role of Bcl-2 family of proteins in mediating apoptosis of PC12 cells exposed to the conditions of oxygen and glucose deprivation (OGD) or OGD followed by restoration of oxygen and glucose (OGD-restoration, OGD-R).	Oxygen	191-197	BCL2, apoptosis regulator	Rattus norvegicus	29-34
16182452-8	2005	In conclusion, these data demonstrated that glucocorticoid exposure modulated oxygen-glucose deprivation-mediated propidium iodide uptake, which likely involved glucocorticoid receptor activation and pro-oxidant effects.	Oxygen	78-84	nuclear receptor subfamily 3 group C member 1	Homo sapiens	161-184
16113471-1	2005	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15571394-2	2004	Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-state (TS) analogues in the immucillin family showed an unusual geometric arrangement of the atoms O-5", O-4", and O(P), the nucleophilic phosphate oxygen, lying in a close three-oxygen stack.	Oxygen	245-251	purine nucleoside phosphorylase	Homo sapiens	34-65
16060122-5	2005	Oxygen induced significant increments in glomerular filtration rate (90 +/- 21 to 111 +/- 36 mL/min/1.73 m2, p = 0.03), sodium filtered load (10 +/- 3 to 12 +/- 5 mEq/min, p = 0.004), sodium excreted load (79 +/- 67 to 194 +/- 106 mEq/day, p = 0.0006), fractional excretion of sodium (0.51 +/- 0.49 to 1.30 +/- 1.32%, p = 0.015) diuresis (1048 +/- 548 to 1893 +/- 440 mL/day, p = 0.002), osmolar clearance (1.43 +/- 0.7 to 2.08 +/- 0.6 mOsm/min, p = 0.008) and decreased hematocrit (48 +/- 4 to 44 +/- 3%, p = 0.0038).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	96-101
15589727-6	2005	In total, five oxygen sites were identified in these borophosphate glasses: P-O-P, Na...O-P, P-O-B, B-O-B, Na...O-B.	Oxygen	15-21	ER membrane protein complex subunit 3	Homo sapiens	93-105
15606203-7	2004	The octahedral geometry around each Pb(II) is satisfied by coordination to 3 nitrogen atoms, two oxygen atoms of the chelating acetate group, and bridging of one of the oxygen atoms of the nearby acetate.	Oxygen	97-103	submaxillary gland androgen regulated protein 3B	Homo sapiens	36-42
15606203-7	2004	The octahedral geometry around each Pb(II) is satisfied by coordination to 3 nitrogen atoms, two oxygen atoms of the chelating acetate group, and bridging of one of the oxygen atoms of the nearby acetate.	Oxygen	169-175	submaxillary gland androgen regulated protein 3B	Homo sapiens	36-42
15623619-0	2004	Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
16180943-1	2005	The administration of recombinant human erythropoietin (rhEPO) increases the maximum oxygen consumption capacity, and is therefore abused as a doping method in endurance sports.	Oxygen	85-91	erythropoietin	Homo sapiens	40-54
15625007-4	2004	Accordingly, the activation of human neutrophil FPR and FPRL1 induces identical, pertussis toxin-sensitive functional responses and a transient increase in intracellular calcium is followed by a secretory response leading to mobilization of receptors from intracellular stores, as well as a release of reactive oxygen metabolites.	Oxygen	311-317	formyl peptide receptor 1	Homo sapiens	48-51
15597054-4	2004	Since the snail has non-magnetic hemocyanins as oxygen carrying protein, it seems that the image intensity change is mainly due to the local magnetic fields produced by the neuronal currents.	Oxygen	48-54	snail family transcriptional repressor 1	Homo sapiens	10-15
15604406-3	2004	We found that IRP2-/- cells misregulated iron metabolism when cultured in 3 to 6% oxygen, which is comparable to physiological tissue concentrations, but not in 21% oxygen, a concentration that activated IRP1 and allowed it to substitute for IRP2.	Oxygen	82-88	iron responsive element binding protein 2	Homo sapiens	14-18
15604406-4	2004	Thus, IRP2 dominates regulation of mammalian iron homeostasis because it alone registers iron concentrations and modulates its RNA-binding activity at physiological oxygen tensions.	Oxygen	165-171	iron responsive element binding protein 2	Homo sapiens	6-10
15604270-1	2004	Hypoxia-inducible factor (HIF)-1, a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits coordinates pathophysiologic responses toward decreased oxygen availability.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
15485853-4	2004	A member of this family, GCY-35 in C. elegans, was recently shown to be required for a behavioral response to low oxygen levels and may be directly regulated by oxygen (Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., Marletta, M. A., and Bargmann, C. I.	Oxygen	114-120	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	25-31
15571394-2	2004	Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-state (TS) analogues in the immucillin family showed an unusual geometric arrangement of the atoms O-5", O-4", and O(P), the nucleophilic phosphate oxygen, lying in a close three-oxygen stack.	Oxygen	245-251	purine nucleoside phosphorylase	Homo sapiens	67-71
15485853-4	2004	A member of this family, GCY-35 in C. elegans, was recently shown to be required for a behavioral response to low oxygen levels and may be directly regulated by oxygen (Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., Marletta, M. A., and Bargmann, C. I.	Oxygen	161-167	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	25-31
15485853-7	2004	COS-7 cells co-transfected with Gyc-88E and Gyc-89Da or Gyc-89Db accumulate low levels of cGMP under normal atmospheric oxygen concentrations and are potently activated under anoxic conditions.	Oxygen	120-126	Guanylyl cyclase at 89Da	Drosophila melanogaster	44-52
15571394-2	2004	Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-state (TS) analogues in the immucillin family showed an unusual geometric arrangement of the atoms O-5", O-4", and O(P), the nucleophilic phosphate oxygen, lying in a close three-oxygen stack.	Oxygen	276-282	purine nucleoside phosphorylase	Homo sapiens	34-65
15571394-2	2004	Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-state (TS) analogues in the immucillin family showed an unusual geometric arrangement of the atoms O-5", O-4", and O(P), the nucleophilic phosphate oxygen, lying in a close three-oxygen stack.	Oxygen	276-282	purine nucleoside phosphorylase	Homo sapiens	67-71
15571394-4	2004	We propose that protein-facilitated dynamic modes in hPNP cause this stack, centered on the ribosyl O-4" oxygen, to squeeze together and push electrons toward the purine ring, stabilizing the oxacarbenium character of the TS.	Oxygen	105-111	purine nucleoside phosphorylase	Homo sapiens	53-57
15571394-13	2004	Our calculations showed the existence of PPVs coupled to the reaction coordinate, which effect electronic alterations in the active site by pushing the three oxygen centers together in proximity, and accelerate substrate turnover in the phosphorolysis reaction catalyzed by hPNP.	Oxygen	158-164	purine nucleoside phosphorylase	Homo sapiens	274-278
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-108
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-115
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	59-65	vascular endothelial growth factor A	Homo sapiens	287-291
15592306-6	2004	The apoptotic index was reduced by &gt;/=30% ( P &lt;.001), and the expression of p53 was 2-fold lower ( P &lt;.02) in troglitazone-exposed cells under hypoxia for &lt;/=16 hours but not different after &gt;24 hours of low oxygen.	Oxygen	223-229	tumor protein p53	Homo sapiens	82-85
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	59-65	erythropoietin	Homo sapiens	293-307
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	266-272	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-108
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	266-272	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-115
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	266-272	vascular endothelial growth factor A	Homo sapiens	287-291
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	266-272	erythropoietin	Homo sapiens	293-307
15644946-1	2004	The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner.	Oxygen	188-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
15548897-5	2004	Within extravascular cells, the global regulator of oxygen homeostasis is hypoxia-inducible factor-1 (HIF- 1).	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-100
15548897-5	2004	Within extravascular cells, the global regulator of oxygen homeostasis is hypoxia-inducible factor-1 (HIF- 1).	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-108
15548897-7	2004	HIF-1 activation is responsible for the up-regulation of proteins, which increase O(2) supply.	Oxygen	82-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15644946-1	2004	The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner.	Oxygen	188-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
15616384-4	2004	Vasopressin but not norepinephrine improved renal blood flow and oxygen delivery and prolonged survival in animal models of septic shock.	Oxygen	65-71	arginine vasopressin	Homo sapiens	0-11
20368827-2	2004	One mechanism by which tumor cells respond to a reduced oxygen level is via the activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-120
20368827-2	2004	One mechanism by which tumor cells respond to a reduced oxygen level is via the activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-127
20368827-3	2004	HIF-1 is an oxygen-dependent transcriptional activator that plays crucial roles in the angiogenesis of tumors and mammalian development.	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
20368827-8	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Oxygen	183-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
15616384-7	2004	In hypodynamic animal models of sepsis vasopressin compromised oxygen delivery and decreased systemic and gut blood flow.High-dose bolus vasopressin appeared promising in animal studies of hemorrhagic shock and cardiopulmonary arrest and in a large, randomized clinical trial of vasopressin versus epinephrine in human cardiopulmonary arrest with asystole.	Oxygen	63-69	arginine vasopressin	Homo sapiens	39-50
15616384-7	2004	In hypodynamic animal models of sepsis vasopressin compromised oxygen delivery and decreased systemic and gut blood flow.High-dose bolus vasopressin appeared promising in animal studies of hemorrhagic shock and cardiopulmonary arrest and in a large, randomized clinical trial of vasopressin versus epinephrine in human cardiopulmonary arrest with asystole.	Oxygen	63-69	arginine vasopressin	Homo sapiens	137-148
15616384-7	2004	In hypodynamic animal models of sepsis vasopressin compromised oxygen delivery and decreased systemic and gut blood flow.High-dose bolus vasopressin appeared promising in animal studies of hemorrhagic shock and cardiopulmonary arrest and in a large, randomized clinical trial of vasopressin versus epinephrine in human cardiopulmonary arrest with asystole.	Oxygen	63-69	arginine vasopressin	Homo sapiens	137-148
15642323-9	2004	Furthermore, Sod2-deficient cells showed dramatic mitochondrial damage, cytochrome C leakage, caspase 3 activation and increased apoptotic cell death when they were challenged with O2-.	Oxygen	181-183	caspase 3	Homo sapiens	94-103
15563698-2	2004	The aim of this study was to investigate whether short term supplementary oxygen (28%) increases oxidative stress and inflammation in the airways by measuring 8-isoprostane and interleukin 6 (IL-6) concentrations in exhaled breath condensate.	Oxygen	74-80	interleukin 6	Homo sapiens	177-190
15545626-8	2004	Furthermore, we show that scylla and charybdis are induced under hypoxic conditions and that scylla is a target of Drosophila HIF-1 (hypoxia-inducible factor-1) like its mammalian counterpart RTP801/REDD1, thus establishing a potential cross-talk between growth and oxygen sensing.	Oxygen	266-272	similar	Drosophila melanogaster	133-159
15590400-1	2004	BACKGROUND AND OBJECTIVES: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites.	Oxygen	150-156	NAD(P)H quinone dehydrogenase 1	Homo sapiens	27-59
15590400-1	2004	BACKGROUND AND OBJECTIVES: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites.	Oxygen	150-156	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
15620241-12	2004	Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
15620241-12	2004	Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
15620252-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that induces oxygen-regulated genes in response to reduced oxygen conditions (hypoxia).	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15620252-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that induces oxygen-regulated genes in response to reduced oxygen conditions (hypoxia).	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15620252-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that induces oxygen-regulated genes in response to reduced oxygen conditions (hypoxia).	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15620252-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that induces oxygen-regulated genes in response to reduced oxygen conditions (hypoxia).	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15620252-2	2004	Expression of the oxygen-regulated HIF-1alpha subunit correlates positively with advanced disease stages and poor prognosis in cancer patients.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
15557261-5	2004	A putative orientation for the phosphorylcholine head group of the ASM substrate, sphingomyelin (SM), was made based on the predicted catalysis of the phosphorus-oxygen bond in the active site of ASM and on a structural comparison of the PAP-phosphate complex to the C-reactive protein-phosphorylcholine complex.	Oxygen	162-168	sphingomyelin phosphodiesterase 1	Homo sapiens	67-70
15557261-5	2004	A putative orientation for the phosphorylcholine head group of the ASM substrate, sphingomyelin (SM), was made based on the predicted catalysis of the phosphorus-oxygen bond in the active site of ASM and on a structural comparison of the PAP-phosphate complex to the C-reactive protein-phosphorylcholine complex.	Oxygen	162-168	sphingomyelin phosphodiesterase 1	Homo sapiens	196-199
15455214-4	2004	Up-regulated genes, clustered mainly in biological processes involving cell adhesion/cytoskeleton, extracellular matrix components, cell cycle, protein modification/phosphorylation, protein metabolism, transcription and inflammation/stress (e.g. key iron and oxygen sensor EGLN1).	Oxygen	259-265	egl-9 family hypoxia inducible factor 1	Homo sapiens	273-278
15563698-2	2004	The aim of this study was to investigate whether short term supplementary oxygen (28%) increases oxidative stress and inflammation in the airways by measuring 8-isoprostane and interleukin 6 (IL-6) concentrations in exhaled breath condensate.	Oxygen	74-80	interleukin 6	Homo sapiens	192-196
15563698-5	2004	RESULTS: Increased concentrations of 8-isoprostane and IL-6 were found in all subjects after breathing 28% oxygen for 1 hour.	Oxygen	107-113	interleukin 6	Homo sapiens	55-59
15730782-10	2004	CEA was increased in I-PAP patients [(12.85 +/- 3.79) ng/ml] compared with disease control [(2.04 +/- 0.63) ng/ml] and health control [(1.46 +/- 0.34) ng/ml] and correlated with alveolar-artery oxygen gradient (r = 0.552).	Oxygen	194-200	CEA cell adhesion molecule 3	Homo sapiens	0-3
15585142-1	2004	OBJECTIVE: To observe the changes in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP) so as to provide a theoretical basis for clinical treatment.	Oxygen	54-60	amyloid P component, serum	Sus scrofa	112-115
15585142-9	2004	CONCLUSION: There is not only hemodynamic disturbances but also oxygen metabolism dysfunction in pigs with SAP.	Oxygen	64-70	amyloid P component, serum	Sus scrofa	107-110
15522429-7	2004	Recombinant CYP1A protein expressed in yeast was mainly in the denatured P420 form under normal microsomal preparation conditions but when the oxygen concentration was reduced in the buffer by degassing and the yeast cells were maintained at less than 10 degrees C, the integrity of the CYP1A was preserved and it exhibited a characteristic reduced CO-difference spectrum maximum at 448 nm.	Oxygen	143-149	cytochrome P450, family 1, subfamily A	Danio rerio	12-17
15257986-3	2004	IFN-gamma is known to be induced in lungs exposed to high concentrations of oxygen; however, its contribution to hyperoxia-induced lung injury remains unclear.	Oxygen	76-82	interferon gamma	Mus musculus	0-9
15556623-0	2004	The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-71
15556623-5	2004	We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions.	Oxygen	201-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-132
15556623-5	2004	We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions.	Oxygen	201-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
15556623-5	2004	We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions.	Oxygen	233-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-132
15556623-5	2004	We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions.	Oxygen	233-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
15477015-5	2004	Because this enzyme needs molecular oxygen to perform the reaction, we have hypothesized that oxygen present in the alveolar space favors the generation of free radicals by xanthine oxidase and explains why P-selectin is expressed only in the lung.	Oxygen	36-42	selectin P	Rattus norvegicus	207-217
15477015-5	2004	Because this enzyme needs molecular oxygen to perform the reaction, we have hypothesized that oxygen present in the alveolar space favors the generation of free radicals by xanthine oxidase and explains why P-selectin is expressed only in the lung.	Oxygen	94-100	selectin P	Rattus norvegicus	207-217
15465032-2	2004	HIF-1 consists of an oxygen-sensitive HIF-1alpha and oxygen-insensitive HIF-1beta.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15465032-2	2004	HIF-1 consists of an oxygen-sensitive HIF-1alpha and oxygen-insensitive HIF-1beta.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48
15465032-2	2004	HIF-1 consists of an oxygen-sensitive HIF-1alpha and oxygen-insensitive HIF-1beta.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15465032-3	2004	Oxygen-sensitive HIF-1alpha is subjected to post-translational modifications such as hydroxylation, ubiquitination, and acetylation, which are related to the regulation of its stability.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
15476858-1	2004	NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of neoplasia.	Oxygen	102-108	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-32
15476858-1	2004	NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of neoplasia.	Oxygen	102-108	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-38
15358808-0	2004	Influence of nitric oxide synthase inhibition on pulmonary O2 uptake kinetics during supra-maximal exercise in humans.	Oxygen	59-61	nitric oxide synthase 2	Homo sapiens	13-34
15358808-1	2004	We have recently reported that inhibition of nitric oxide synthase (NOS) with N(G)-nitro-L-arginine methyl ester (L-NAME) accelerates the "phase II" pulmonary O2 uptake (VO2) kinetics following the onset of moderate and heavy intensity submaximal exercise in humans.	Oxygen	159-161	nitric oxide synthase 2	Homo sapiens	45-66
15328343-8	2004	Together, these studies indicate that PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response.	Oxygen	100-106	mitogen-activated protein kinase kinase 4	Homo sapiens	158-162
15328343-8	2004	Together, these studies indicate that PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response.	Oxygen	100-106	mitogen-activated protein kinase 8	Homo sapiens	163-166
15505715-4	2004	The Fe(II) complexes formed dioxygen (O2) adducts in dimethylformamide at 25 degrees C. Some of them were incorporated into the hydrophobic domain of recombinant human serum albumin (rHSA), providing albumin-heme hybrids (rHSA-heme), which can bind and release O2 in aqueous media (pH 7.3, 25 degrees C).	Oxygen	28-36	albumin	Homo sapiens	168-181
15505715-4	2004	The Fe(II) complexes formed dioxygen (O2) adducts in dimethylformamide at 25 degrees C. Some of them were incorporated into the hydrophobic domain of recombinant human serum albumin (rHSA), providing albumin-heme hybrids (rHSA-heme), which can bind and release O2 in aqueous media (pH 7.3, 25 degrees C).	Oxygen	38-41	albumin	Homo sapiens	168-181
15505715-4	2004	The Fe(II) complexes formed dioxygen (O2) adducts in dimethylformamide at 25 degrees C. Some of them were incorporated into the hydrophobic domain of recombinant human serum albumin (rHSA), providing albumin-heme hybrids (rHSA-heme), which can bind and release O2 in aqueous media (pH 7.3, 25 degrees C).	Oxygen	38-40	albumin	Homo sapiens	168-181
15547537-7	2004	In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P &lt; .05).	Oxygen	70-76	interleukin 6	Homo sapiens	16-20
15516132-5	2004	With the aid of a scanning electrochemical microscope, it was possible to use the distance sensor by recording the negative feedback effect on the reduction of molecular oxygen to "guide" the nitric oxide sensor to various known distances from a layer of adherently growing human umbilical vein endothelial cells for the detection of nitric oxide released from the cells upon stimulation with bradykinin.	Oxygen	170-176	kininogen 1	Homo sapiens	393-403
15464726-1	2004	We have studied the peroxidase-oxidase reaction catalyzed by human myeloperoxidase in an open system where both substrates-molecular oxygen and NADH-are supplied continuously to the reaction mixture.	Oxygen	133-139	myeloperoxidase	Homo sapiens	67-82
15804831-7	2004	Cytoglobin may hypothetically be involved in the oxygen-consuming maturation of collagen proteins.	Oxygen	49-55	cytoglobin	Homo sapiens	0-10
15492505-3	2004	In hypoxia, HIF-1alpha is stabilized as a result of inhibition of HIF-1alpha hydroxylation, which in part is achieved by decreased activity of PHD enzymes at very low oxygen concentrations.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
15492505-3	2004	In hypoxia, HIF-1alpha is stabilized as a result of inhibition of HIF-1alpha hydroxylation, which in part is achieved by decreased activity of PHD enzymes at very low oxygen concentrations.	Oxygen	167-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
15522599-4	2004	The second step is that the amount of Agm is determined by the amount of oxygen consumed in the AUH-PuOx reactor.	Oxygen	73-79	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	96-99
15284201-3	2004	To address this, we explored the effect of oxygen tension on the expression of VEGF, placenta growth factor (PlGF), and their antagonist, soluble fms-like tyrosine kinase-1 (sFlt-1) using ELISA and real-time PCR in a primary CT cell culture.	Oxygen	43-49	vascular endothelial growth factor A	Homo sapiens	79-83
15284201-3	2004	To address this, we explored the effect of oxygen tension on the expression of VEGF, placenta growth factor (PlGF), and their antagonist, soluble fms-like tyrosine kinase-1 (sFlt-1) using ELISA and real-time PCR in a primary CT cell culture.	Oxygen	43-49	placental growth factor	Homo sapiens	85-107
15284201-6	2004	Free (not bound to sFlt-1) VEGF was not detected in CT culture media regardless of oxygen concentration, even though VEGF expression was stimulated by reduced oxygen in CTs, which was similar to the stimulation in HUVECs and VFs.	Oxygen	159-165	vascular endothelial growth factor A	Homo sapiens	117-121
15284201-7	2004	Free PlGF was also diminished in CT culture media by reduced oxygen.	Oxygen	61-67	placental growth factor	Homo sapiens	5-9
15284201-8	2004	These results implicate that CTs possess a unique property to enhance sFlt-1 production under reduced oxygen, which could consequently antagonize angiogenic activity of VEGF and PlGF.	Oxygen	102-108	vascular endothelial growth factor A	Homo sapiens	169-173
15284201-8	2004	These results implicate that CTs possess a unique property to enhance sFlt-1 production under reduced oxygen, which could consequently antagonize angiogenic activity of VEGF and PlGF.	Oxygen	102-108	placental growth factor	Homo sapiens	178-182
15804829-5	2004	Cygb is linked to collagen synthesis, may provide O2 for enzymatic reactions, and may be involved in a ROS(NO)-signaling pathway(s).	Oxygen	50-52	cytoglobin	Homo sapiens	0-4
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	cytoglobin	Homo sapiens	72-82
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	cytoglobin	Homo sapiens	84-88
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	cytoglobin	Homo sapiens	72-82
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	cytoglobin	Homo sapiens	84-88
15804832-2	2004	The Cygb gene harbours both conserved HREs and mRNA stabilization sites, strongly suggestive of an oxygen-dependent regulation.	Oxygen	99-105	cytoglobin	Homo sapiens	4-8
15804833-8	2004	The O2 binding properties of cytoglobin, which is upregulated upon hypoxia, are consistent with a role for this protein in O2-requiring reactions, such as those catalysed by hydroxylases.	Oxygen	4-6	cytoglobin	Homo sapiens	29-39
15804833-8	2004	The O2 binding properties of cytoglobin, which is upregulated upon hypoxia, are consistent with a role for this protein in O2-requiring reactions, such as those catalysed by hydroxylases.	Oxygen	123-125	cytoglobin	Homo sapiens	29-39
15496383-8	2004	Macrophage migration inhibition factor (MIF) and IL4 responses during anti-CD3 stimulation of immunized mice indicated that the role of anti-CD3 in generation of O2- is due to a synergistic effect by Th1 subsets of Th0 cells.	Oxygen	162-164	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	40-43
15496383-8	2004	Macrophage migration inhibition factor (MIF) and IL4 responses during anti-CD3 stimulation of immunized mice indicated that the role of anti-CD3 in generation of O2- is due to a synergistic effect by Th1 subsets of Th0 cells.	Oxygen	162-164	negative elongation factor complex member C/D, Th1l	Mus musculus	200-203
15514500-5	2004	RESULTS: Maximal oxygen uptake increased by 18% to 50.4 +/- 3.1 mL x kg(-1) x min(-1) (P &lt; 0.001).	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	78-84
15475194-7	2004	We found that both normal and malignant chondrocytes increased HIF-1alpha protein expression in an oxygen concentration dependent manner and also increased VEGF mRNA expression in response to hypoxia.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
15531071-0	2004	Cerebral oximetry in out-of-hospital cardiac arrest: standard CPR rarely provides detectable hemoglobin-oxygen saturation to the frontal cortex.	Oxygen	104-110	cytochrome p450 oxidoreductase	Homo sapiens	62-65
15380813-0	2004	Impact of intravenous oxygen therapy on the expression of reticulocyte-type 15-lipoxygenase in human volunteers.	Oxygen	22-28	arachidonate 15-lipoxygenase	Homo sapiens	76-91
15380813-2	2004	Since this subset of human peripheral leukocytes are known to express large amounts of the reticulocyte-type 15-lipoxygenase (15-lipoxygenase 1), which was suggested to exhibit anti-inflammatory activities, we profiled expression of this enzyme in the peripheral blood during the time course of typical oxygen infusion therapy.	Oxygen	115-121	arachidonate 15-lipoxygenase	Homo sapiens	126-141
15477159-9	2004	alpha2 and gamma2 increase with increase in x in both the series, which indicates that, the covalency of the vanadium oxygen bonds decreases.	Oxygen	118-124	tryptophanyl-tRNA synthetase 1	Homo sapiens	11-17
15474364-5	2004	Oxygen caused oxidative stress, decreased expression of neurotrophins, and inactivation of survival signaling proteins Ras, extracellular signal-regulated kinase (ERK 1/2), and protein kinase B (Akt).	Oxygen	0-6	mitogen-activated protein kinase 3	Homo sapiens	163-170
15474364-5	2004	Oxygen caused oxidative stress, decreased expression of neurotrophins, and inactivation of survival signaling proteins Ras, extracellular signal-regulated kinase (ERK 1/2), and protein kinase B (Akt).	Oxygen	0-6	AKT serine/threonine kinase 1	Homo sapiens	195-198
15600254-9	2004	Myeloperoxidase (MPD) is a heme enzyme, participating in oxygen mechanisms of microorganism killing by phagocytes.	Oxygen	57-63	myeloperoxidase	Homo sapiens	0-15
15496093-0	2004	Oxygen-promoted palladium(II) catalysis: facile C(sp2)-C(sp2) bond formation via cross-coupling of alkenylboronic compounds and olefins.	Oxygen	0-6	Sp2 transcription factor	Homo sapiens	48-53
21158113-6	2004	The expression of HIF-1alpha mRNA decreased with the deprivation of both oxygen and glucose, which reversed after the pretreatment of Gin.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
15496093-0	2004	Oxygen-promoted palladium(II) catalysis: facile C(sp2)-C(sp2) bond formation via cross-coupling of alkenylboronic compounds and olefins.	Oxygen	0-6	Sp2 transcription factor	Homo sapiens	55-60
15322093-1	2004	Hypoxia-Inducible Factor-1 (HIF-1) is the key transcription factor in control of the expression of hypoxia-inducible genes needed by cells to adapt to decreased oxygen availability.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15299006-0	2004	Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin.	Oxygen	52-58	cytoglobin	Homo sapiens	92-102
15299006-3	2004	In analogy to hemoglobin and myoglobin, neuroglobin and cytoglobin are supposedly involved in O2 storage and delivery, although their physiological role remains to be solved.	Oxygen	94-96	cytoglobin	Homo sapiens	56-66
15299006-8	2004	In CYGB, O2 binding is cooperative, consistent with its proposed dimeric structure.	Oxygen	9-11	cytoglobin	Homo sapiens	3-7
15299006-9	2004	Similar to myoglobin but in contrast to NGB, O2 binding to CYGB is pH-independent and exothermic throughout the temperature range investigated.	Oxygen	45-47	cytoglobin	Homo sapiens	59-63
15299006-10	2004	Our data support the hypothesis that CYGB may be involved in O2-requiring metabolic processes.	Oxygen	61-63	cytoglobin	Homo sapiens	37-41
15640758-0	2004	Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury.	Oxygen	22-28	glial cell derived neurotrophic factor	Homo sapiens	32-36
15640758-4	2004	The gene expression of glial cell line-derived neurotrophic factor (GDNF) and inducible nitric oxide synthetase (iNOS) was significantly attenuated 1 day after the injury in the hyperbaric oxygen groups compared with the control group.	Oxygen	189-195	glial cell derived neurotrophic factor	Homo sapiens	23-66
15640758-4	2004	The gene expression of glial cell line-derived neurotrophic factor (GDNF) and inducible nitric oxide synthetase (iNOS) was significantly attenuated 1 day after the injury in the hyperbaric oxygen groups compared with the control group.	Oxygen	189-195	glial cell derived neurotrophic factor	Homo sapiens	68-72
15640758-4	2004	The gene expression of glial cell line-derived neurotrophic factor (GDNF) and inducible nitric oxide synthetase (iNOS) was significantly attenuated 1 day after the injury in the hyperbaric oxygen groups compared with the control group.	Oxygen	189-195	nitric oxide synthase 2	Homo sapiens	78-111
15640758-4	2004	The gene expression of glial cell line-derived neurotrophic factor (GDNF) and inducible nitric oxide synthetase (iNOS) was significantly attenuated 1 day after the injury in the hyperbaric oxygen groups compared with the control group.	Oxygen	189-195	nitric oxide synthase 2	Homo sapiens	113-117
15640758-6	2004	Early hyperbaric oxygen treatment was shown to effectively suppress the progress of apoptosis perhaps via the inhibition of iNOS gene despite the down-regulation of the GDNF gene.	Oxygen	17-23	nitric oxide synthase 2	Homo sapiens	124-128
15640758-6	2004	Early hyperbaric oxygen treatment was shown to effectively suppress the progress of apoptosis perhaps via the inhibition of iNOS gene despite the down-regulation of the GDNF gene.	Oxygen	17-23	glial cell derived neurotrophic factor	Homo sapiens	169-173
15322093-1	2004	Hypoxia-Inducible Factor-1 (HIF-1) is the key transcription factor in control of the expression of hypoxia-inducible genes needed by cells to adapt to decreased oxygen availability.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15474019-2	2004	The CuA domain of cytochrome c oxidase, the terminal enzyme which catalyzes the four-electron reduction of molecular oxygen in the respiratory chains of mitochondria and many bacteria, also has a periplasmic location.	Oxygen	117-123	cytochrome c, somatic	Homo sapiens	18-30
15388638-5	2004	Similar to OS, BMP4 stimulated H2O2 and O2- production in ECs.	Oxygen	33-35	bone morphogenetic protein 4	Mus musculus	15-19
15461448-9	2004	In contrast, light-dependent, oxygen-dependent, oxidation of A1-1 was modest and oxidation of human albumin was extensive in the presence of HYP, as monitored by electrospray mass spectrometry (ESI-MS).	Oxygen	30-36	BCL2 related protein A1	Homo sapiens	61-65
15483710-1	2004	The oxygen-atom transfer reaction from the bis(mu-oxo)dicopper(III) complex [Cu(III)(2)(mu-O)(2)(L)(2)](2+), where L =N,N,N",N" -tetraethylethylenediamine, to PPh(3) has been studied by UV-vis, EPR, (1)H NMR and Cu K-edge X-ray absorption spectroscopy in parallel at low temperatures (193 K) and above.	Oxygen	4-10	caveolin 1	Homo sapiens	159-165
15483710-2	2004	Under aerobic conditions (excess dioxygen), 1 reacted with PPh(3), giving O=Ph(3) and a diamagnetic species that has been assigned to an oxo-bridged dicopper(II) complex on the basis of EPR and Cu K-edge X-ray absorption spectroscopic data.	Oxygen	33-41	caveolin 1	Homo sapiens	59-65
15483710-6	2004	By contrast, when the reaction was performed in the absence of excess dioxygen, negligible substrate (PPh(3)) oxidation was observed.	Oxygen	70-78	caveolin 1	Homo sapiens	102-108
15302861-7	2004	Evidence for FIH activity in severely hypoxic cells contrasted with results for the prolyl hydroxylase PHD2, suggesting that these enzymes display different oxygen dependence in vivo, with PHD2 requiring higher levels of oxygen for biological activity.	Oxygen	221-227	egl-9 family hypoxia inducible factor 1	Homo sapiens	189-193
15474027-3	2004	We show that all three are capable of high rates of catalysis, in the order PHD2=PHD3&gt;PHD1, using substrate peptides derived from the C-terminal degradation domain of HIF-alpha subunits, and that each demonstrates similar and remarkable sensitivity to oxygen, commensurate with a common role in signaling hypoxia.	Oxygen	255-261	egl-9 family hypoxia inducible factor 1	Homo sapiens	76-80
15205261-5	2004	We find that EPOR is inducible by EPO in primary human endothelial cells of vein (HUVECs) and artery (HUAECs) and cells from a human bone marrow microvascular endothelial line (TrHBMEC) to a much greater extent at low oxygen tension than in room air.	Oxygen	218-224	erythropoietin	Homo sapiens	13-16
15388552-9	2004	RCP occurred on average at a significantly (p = 0.043) higher oxygen uptake (+0.15 l x min(-1)) compared with the first test.	Oxygen	62-68	CD59 molecule (CD59 blood group)	Homo sapiens	87-93
15205261-3	2004	In this study we investigated the EPO response of vascular endothelial cells at reduced oxygen tension (5% and 2%), in particular the effect of EPO on nitric oxide (NO) release.	Oxygen	88-94	erythropoietin	Homo sapiens	34-37
15205261-9	2004	These results suggest that low oxygen tension increases endothelial cell capacity to produce NO in response to EPO by induction of both EPOR and eNOS.	Oxygen	31-37	erythropoietin	Homo sapiens	111-114
15280364-1	2004	Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
15466261-3	2004	When oxygen tension falls, HIF-alpha subunits translocate to the nucleus and, upon dimerization with HIF-beta, activate transcription of target genes, including vascular endothelial growth factor, vascular endothelial growth factor receptor-1 and -2, and WT-1, which are vital for kidney development.	Oxygen	5-11	WT1 transcription factor	Homo sapiens	255-259
15280364-1	2004	Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	116-122	vascular endothelial growth factor A	Homo sapiens	142-176
15280364-1	2004	Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	116-122	vascular endothelial growth factor A	Homo sapiens	178-182
15486189-8	2004	Like UCN-01, isogranulatimide binds in the ATP-binding pocket of Chk1 and hydrogen bonds with the backbone carbonyl oxygen of Glu(85) and the amide nitrogen of Cys(87).	Oxygen	116-122	checkpoint kinase 1	Homo sapiens	65-69
15472216-0	2004	Growth hormone treatment improves peripheral muscle oxygen extraction-utilization during exercise in patients with human immunodeficiency virus-associated wasting: a randomized controlled trial.	Oxygen	52-58	growth hormone 1	Homo sapiens	0-14
15361774-4	2004	Insulin-adjusted glucose disposal rate (GDR/I) was measured with a 90-min hyperinsulinaemic glucose clamp and fitness by peak oxygen uptake (VO2peak) during a treadmill test.	Oxygen	126-132	insulin	Homo sapiens	0-7
15465804-2	2004	Nitric oxide synthase (NOS) utilizes L-arginine and oxygen as substrates to produce nitric oxide (NO) and citrulline.	Oxygen	52-58	nitric oxide synthase 2	Homo sapiens	0-21
15552949-4	2004	Mean PaO2 and PaCO2 were 76.5 mmHg and 45.5 mmHg, respectively, under nasal oxygen of 1.67 l x min(-1).	Oxygen	76-82	CD59 molecule (CD59 blood group)	Homo sapiens	95-101
15601571-2	2004	The lack of O(2) (hypoxia) is transmitted into many adaptive responses, a process that is largely controlled by a transcription factor known as hypoxia inducible factor-1 (HIF-1).	Oxygen	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-170
15601571-2	2004	The lack of O(2) (hypoxia) is transmitted into many adaptive responses, a process that is largely controlled by a transcription factor known as hypoxia inducible factor-1 (HIF-1).	Oxygen	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-177
15477108-4	2004	RESULTS: The MHF and HTR groups had similar ventilatory responses to exercise and O(2) recovery kinetics.	Oxygen	82-86	telomerase RNA component	Homo sapiens	21-24
15387607-5	2004	The oxidative decarboxylation of these latter with oxygen as terminal oxidant in the presence of pivalaldehyde and the Co(III)-Me2opba complex as catalyst gives substituted nitrobenzophenones.	Oxygen	51-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	119-125
15474879-6	2004	RESULTS: Maximal oxygen consumption (corrected for body weight) values were 29.9 +/- 6.7 mL x kg(-1) x min(-1) in group 1 and 47.2 +/- 5.3 mL x kg(-1) x min(-1) in group 2 (P &lt; 0.05).	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	103-109
15336552-5	2004	This is in agreement with our recent observation using other inhibitors of mitochondrial respiration which bring about rapid degradation of HIF1alpha in hypoxia due to increased availability of oxygen and reactivation of prolyl hydroxylases.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-149
15328538-3	2004	Glycolysis is the central source of anaerobic energy in animals, and this metabolic pathway is regulated under low-oxygen conditions by the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-192
15328538-3	2004	Glycolysis is the central source of anaerobic energy in animals, and this metabolic pathway is regulated under low-oxygen conditions by the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	194-204
15377891-6	2004	However, parameters related to microvascular oxygen distribution were significantly lower in the MalPEG-Alb group compared with the previous data from the MalPEG-Hb group in that tissue oxygen partial pressure was 5 +/- 2 mmHg (vs. 8 +/- 3 mmHg, P &lt; 0.05), oxygen delivery was reduced to 60 +/- 27% (P &lt; 0.05), and oxygen consumption was reduced to 69 +/- 28% (P &lt; 0.05).	Oxygen	45-51	albumin	Homo sapiens	104-107
15377891-6	2004	However, parameters related to microvascular oxygen distribution were significantly lower in the MalPEG-Alb group compared with the previous data from the MalPEG-Hb group in that tissue oxygen partial pressure was 5 +/- 2 mmHg (vs. 8 +/- 3 mmHg, P &lt; 0.05), oxygen delivery was reduced to 60 +/- 27% (P &lt; 0.05), and oxygen consumption was reduced to 69 +/- 28% (P &lt; 0.05).	Oxygen	186-192	albumin	Homo sapiens	104-107
15377891-6	2004	However, parameters related to microvascular oxygen distribution were significantly lower in the MalPEG-Alb group compared with the previous data from the MalPEG-Hb group in that tissue oxygen partial pressure was 5 +/- 2 mmHg (vs. 8 +/- 3 mmHg, P &lt; 0.05), oxygen delivery was reduced to 60 +/- 27% (P &lt; 0.05), and oxygen consumption was reduced to 69 +/- 28% (P &lt; 0.05).	Oxygen	186-192	albumin	Homo sapiens	104-107
15377891-6	2004	However, parameters related to microvascular oxygen distribution were significantly lower in the MalPEG-Alb group compared with the previous data from the MalPEG-Hb group in that tissue oxygen partial pressure was 5 +/- 2 mmHg (vs. 8 +/- 3 mmHg, P &lt; 0.05), oxygen delivery was reduced to 60 +/- 27% (P &lt; 0.05), and oxygen consumption was reduced to 69 +/- 28% (P &lt; 0.05).	Oxygen	186-192	albumin	Homo sapiens	104-107
15278417-11	2004	The increase in the levels of antioxidant enzyme activities, for example superoxide dismutase and peroxidase, indicated the presence of excess oxygen uptake and the stressed condition of the plant tissues that arose from haemoglobin supplementation.	Oxygen	143-149	peroxidase 42-like	Gossypium hirsutum	98-108
15454650-7	2004	IL-13 mRNA correlated with forced expiratory volume in 1 second (r = 0.5, p = 0.04) and arterial oxygen tension (r = 0.45, p = 0.03) in emphysema patients.	Oxygen	97-103	interleukin 13	Homo sapiens	0-5
15313390-2	2004	The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and adapting of cells to changes in the O2 level, which is essential for their viability.	Oxygen	116-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
15383669-8	2004	Growth of DAN-G cells in an (18)O(2) atmosphere yielded norlaudanosoline and (S)-reticuline, both labeled at only two of the four oxygen atoms.	Oxygen	130-136	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
15263007-0	2004	Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts.	Oxygen	21-27	RUNX family transcription factor 2	Homo sapiens	75-80
15328013-4	2004	HIF-1alpha expression was sensitive to changes in ambient oxygen concentrations, while its dimerization partner HIF-1beta was constitutively expressed.	Oxygen	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
15313390-2	2004	The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and adapting of cells to changes in the O2 level, which is essential for their viability.	Oxygen	116-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
15313390-4	2004	HIF-1 regulation by post-translational modification is the central theme of the scenario of O2 homeostasis.	Oxygen	92-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15327892-3	2004	Hypoxia-inducible factor-1 (HIF-1), the main transcription factor involved in the cellular response to reduced oxygenation, is shown to bind an HIF binding site (HBS) located in the distal part of the B19 promoter region, but the precise mechanism involved in the oxygen-sensitive upregulation of viral gene expression remains to be elucidated.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15363852-7	2004	In freshly isolated rat renal tubules, aHIF RNA level was increased by acute hypoxia and low in normal supply of oxygen.	Oxygen	113-119	HIF1A antisense RNA 2	Homo sapiens	39-43
15327892-3	2004	Hypoxia-inducible factor-1 (HIF-1), the main transcription factor involved in the cellular response to reduced oxygenation, is shown to bind an HIF binding site (HBS) located in the distal part of the B19 promoter region, but the precise mechanism involved in the oxygen-sensitive upregulation of viral gene expression remains to be elucidated.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15302574-4	2004	Decreasing oxygen concentrations cause strong attenuation of PEDF release resulting in enhanced VEGF/PEDF ratios.	Oxygen	11-17	vascular endothelial growth factor A	Homo sapiens	96-100
15350145-0	2004	A novel multistep mechanism for oxygen binding to ferrous hemoproteins: rapid kinetic analysis of ferrous-dioxy myeloperoxidase (compound III) formation.	Oxygen	32-38	myeloperoxidase	Homo sapiens	112-127
15350145-4	2004	Using spectral and rapid kinetic measurements, we now demonstrate that molecular oxygen (O(2)) binds to ferrous MPO (MPO-Fe(II)) in a distinct and novel mechanism.	Oxygen	81-87	myeloperoxidase	Homo sapiens	112-115
15350145-4	2004	Using spectral and rapid kinetic measurements, we now demonstrate that molecular oxygen (O(2)) binds to ferrous MPO (MPO-Fe(II)) in a distinct and novel mechanism.	Oxygen	81-87	myeloperoxidase	Homo sapiens	117-127
15350145-4	2004	Using spectral and rapid kinetic measurements, we now demonstrate that molecular oxygen (O(2)) binds to ferrous MPO (MPO-Fe(II)) in a distinct and novel mechanism.	Oxygen	89-94	myeloperoxidase	Homo sapiens	112-115
15350145-4	2004	Using spectral and rapid kinetic measurements, we now demonstrate that molecular oxygen (O(2)) binds to ferrous MPO (MPO-Fe(II)) in a distinct and novel mechanism.	Oxygen	89-94	myeloperoxidase	Homo sapiens	117-127
15350145-8	2004	Insights into mechanisms for inactivating MPO and the novel mode of O(2) binding to the hemoprotein may provide important clues toward understanding the catalytic action of MPO.	Oxygen	68-72	myeloperoxidase	Homo sapiens	173-176
15353504-7	2004	Transmural Kv1.5 or Kv2.1 gene transfer "rescues" the developmental deficiency, conferring O2 responsiveness to preterm rabbit DAs.	Oxygen	91-93	potassium voltage-gated channel subfamily A member 5	Homo sapiens	11-16
15339195-3	2004	This is exemplified by the bioelectrocatalyzed cytochrome c-mediated reduction of oxygen and oxidation of lactate in the presence of cytochrome oxidase and lactate dehydrogenase, respectively.	Oxygen	82-88	cytochrome c, somatic	Homo sapiens	47-59
15358106-6	2004	A significant upregulation of the mAM mRNA was observed in monkey cells exposed to low oxygen tension conditions, TGF-beta1, all-trans-retinoic acid, and dexamethasone.	Oxygen	87-93	activating transcription factor 7 interacting protein	Mus musculus	34-37
15514750-0	2004	Synthesis and magnetism of oxygen-bridged tetranuclear defect dicubane Co(II) and Ni(II) clusters.	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
15337024-6	2004	RESULTS: Serum VEGF significantly negatively correlated with arterial oxygen saturation (r = -0.62, p &lt; 0.0001).	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	15-19
15155277-2	2004	Hypoxia, the reduction of oxygen supply, results in adaptationally appropriate alterations in gene expression through the activation of hypoxia-inducible factor 1 (HIF-1) to overcome any shortage of oxygen.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-162
15155277-2	2004	Hypoxia, the reduction of oxygen supply, results in adaptationally appropriate alterations in gene expression through the activation of hypoxia-inducible factor 1 (HIF-1) to overcome any shortage of oxygen.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-169
15155277-2	2004	Hypoxia, the reduction of oxygen supply, results in adaptationally appropriate alterations in gene expression through the activation of hypoxia-inducible factor 1 (HIF-1) to overcome any shortage of oxygen.	Oxygen	199-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-162
15155277-2	2004	Hypoxia, the reduction of oxygen supply, results in adaptationally appropriate alterations in gene expression through the activation of hypoxia-inducible factor 1 (HIF-1) to overcome any shortage of oxygen.	Oxygen	199-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-169
15155277-4	2004	Thyroid hormones have been found to augment the oxygen capacity of the blood by increasing the production of erythropoietin (EPO) and to improve perfusion by vasodilation through the augmented expression of adrenomedullin (ADM).	Oxygen	48-54	erythropoietin	Homo sapiens	109-123
15155277-10	2004	Increased synthesis of HIF-1alpha may contribute to the adaptive response of increased oxygen demand under hyperthyroid conditions.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
15363211-1	2004	Hypoxia-inducible factor-1(HIF-1) is a major transcriptional regulator of O2 homeostasis, and plays a key role in physiology, and pathophysiology, and also in tumor pathogenesis.	Oxygen	74-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
15363211-3	2004	The activities of HIF-1 is mainly determined by HIF-1alpha, which transcriptional activity and DNA-binding ability were strictly regulated by O2 concentration, and other stimuli such as metalion, nitric oxide(NO), reactive oxygen species (ROS), and many growth factors.	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
15363211-3	2004	The activities of HIF-1 is mainly determined by HIF-1alpha, which transcriptional activity and DNA-binding ability were strictly regulated by O2 concentration, and other stimuli such as metalion, nitric oxide(NO), reactive oxygen species (ROS), and many growth factors.	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
15363820-4	2004	However, erythropoietin levels increased (by 20%, P =.037) in patients with severe obstructive sleep apnea after 3.5 hours untreated (lowest O2, 77% +/- 3%), and decreased after 4 hours of continuous positive airway pressure treatment (P =.001).	Oxygen	141-143	erythropoietin	Homo sapiens	9-23
15337026-9	2004	Permeabilization was further demonstrated by augmentation of oxygen consumption in isolated mitochondria after administration of exogenous cytochrome c.	Oxygen	61-67	LOC101107954	Ovis aries	139-151
15508673-4	2004	RESULTS: In the cardiopulmonary resuscitation laboratory, vasopressin improved vital organ blood flow, cerebral oxygen delivery, the probability of restoring spontaneous circulation, and neurologic recovery better than epinephrine.	Oxygen	112-118	arginine vasopressin	Homo sapiens	58-69
15364715-1	2004	OBJECTIVE: To examine tissue hypoxia in the retina and optic nerve head of glaucomatous eyes by the assessment of a transcription factor, hypoxia-inducible factor 1alpha (HIF-1alpha), which is tightly regulated by the cellular oxygen concentration.	Oxygen	227-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-169
15364715-1	2004	OBJECTIVE: To examine tissue hypoxia in the retina and optic nerve head of glaucomatous eyes by the assessment of a transcription factor, hypoxia-inducible factor 1alpha (HIF-1alpha), which is tightly regulated by the cellular oxygen concentration.	Oxygen	227-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
15364715-6	2004	CONCLUSIONS: Because the regions of HIF-1alpha induction represent the areas of decreased oxygen delivery and hypoxic stress, information obtained from this study provides direct evidence that tissue hypoxia is present in the retina and optic nerve head of glaucomatous eyes, and hypoxic signaling is a likely component of the pathogenic mechanisms of glaucomatous neurodegeneration.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
15350301-4	2004	These polymorphisms are found within the oxygen-dependent degradation domain of the HIF-1alpha protein and may be important in the oxygen regulation of the protein via hydroxylation of the proline residue at position 564 (P564) by HIF-alpha prolyl hydroxylase (HIF-PH).	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
15350301-4	2004	These polymorphisms are found within the oxygen-dependent degradation domain of the HIF-1alpha protein and may be important in the oxygen regulation of the protein via hydroxylation of the proline residue at position 564 (P564) by HIF-alpha prolyl hydroxylase (HIF-PH).	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
15292117-12	2004	Vitamin E enhanced the therapeutic effect of the PDE5 inhibitor in this study, supporting the potential use of oxygen free radical scavengers in salvaging erectile function in diabetic patients.	Oxygen	111-117	phosphodiesterase 5A	Homo sapiens	49-53
15490337-7	2004	Also a hint is given to oxygen as a toxic compound though being a chemical prerequisite for aerobic life on earth.	Oxygen	24-30	histidine triad nucleotide binding protein 1	Homo sapiens	7-11
15453585-6	2004	However, the peptide Tyr-Ala-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, which was a strong ACE inhibitor (50% inhibitory concentration, 4.7 microM) also exhibited a high radical scavenging activity (oxygen radical absorbance capacity-fluorescein value, 3.8 micromol of Trolox equivalent per micromol of peptide) and delayed the low-density lipoprotein lipid oxidation induced by Cu2+ at a concentration of approximately 0.16 mg/mg of low-density lipoprotein.	Oxygen	185-191	angiotensin I converting enzyme	Homo sapiens	77-80
15669763-1	2004	Biomimetic oxidation of unactivated carbons for structurally different steroids was studied with a model of cytochrome P-450, oxorutheniumporphyrinate complex, which is generated in situ by 2,6-dichloropyridine N-oxide as an oxygen donor and (5,10,15,20-tetramesitylporphyrinate) ruthenium(II) carbonyl complex and HBr as catalysts.	Oxygen	225-231	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	108-124
15453987-8	2004	Overall, the results suggest that ERK activation is initiated by increased oxygen radical activity and that overactivation of ERK sets off secondary cell death mechanisms in TBI.	Oxygen	75-81	mitogen-activated protein kinase 1	Homo sapiens	34-37
15328060-10	2004	The exact local structure of the inner sphere Co(II) surface complexes, formed by exchanging the H(2)O ligands with surface oxygens, has been already approached but only for the surface planes of the alpha-Al(2)O(3) and rutile monocrystals.	Oxygen	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15244505-0	2004	Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation time.	Oxygen	20-26	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	102-105
15244505-2	2004	To examine the relation between the reaction mechanism and measured phototoxicity, we carefully measured the kinetics of photochemical oxygen consumption and photobleaching during irradiation of ATX-S10.Na(II)-sensitized A549 monolayer cultures.	Oxygen	135-141	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	195-198
15240867-3	2004	Exposure to 80% oxygen led to increased formation of S-nitrosocysteine and 3-nitrotyrosine adducts in lung tissue that were also associated with increased expression of iNOS.	Oxygen	16-22	nitric oxide synthase 2	Rattus norvegicus	169-173
15169765-1	2004	Although hypoxia-inducible factor-alpha (HIFalpha) subunit-specific hydroxylation and proteolytic breakdown explain the binary switch between the presence (hypoxia) and absence (normoxia) of HIFs, little is known of the mechanisms that fine-tune HIF activity under constant, rather than changing, oxygen tensions.	Oxygen	297-303	similar	Drosophila melanogaster	41-44
15447112-3	2004	The oxygen atoms in the formed larger clusters prefer to migrate from the centers to the exterior surfaces, leading to the growth of sp3 silicon cores.	Oxygen	4-10	Sp3 transcription factor	Homo sapiens	133-136
15217912-15	2004	Heterologously expressed human PASMC Kv1.5 generated an O2- and correolide-sensitive I(K) like that in resistance PASMCs.	Oxygen	56-58	potassium voltage-gated channel subfamily A member 5	Homo sapiens	37-42
15287748-9	2004	TtTar4H forms a low-spin, 6-coordinate ferrous-oxy complex, the first of this sGC-related family that binds O2.	Oxygen	108-110	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	78-81
15287748-12	2004	The results reported here, with sequence-related proteins from prokaryotes but in the same family as the sGC heme domain, show that these proteins have evolved to discriminate between ligands such as NO and O2; hence, we term this family H-NOX domains (heme-nitric oxide/oxygen).	Oxygen	207-209	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	105-108
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	Oxygen	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15291622-7	2004	The approach of the oxygen atom cation to acetylene goes over an energy barrier TS1 of 29 kcal/mol (relative to the reactant) and adiabatically leads the CT2 product or a weakly bound intermediate Int1 between CT2 products.	Oxygen	20-26	Wnt family member 1	Homo sapiens	197-201
15287748-12	2004	The results reported here, with sequence-related proteins from prokaryotes but in the same family as the sGC heme domain, show that these proteins have evolved to discriminate between ligands such as NO and O2; hence, we term this family H-NOX domains (heme-nitric oxide/oxygen).	Oxygen	271-277	Guanylyl cyclase alpha-subunit at 99B	Drosophila melanogaster	105-108
15217912-16	2004	In conclusion, Kv1.5 and Kv2.1 account for virtually all the O2-sensitive current.	Oxygen	61-63	potassium voltage-gated channel subfamily A member 5	Homo sapiens	15-20
15280664-3	2004	HIF is degraded in normal oxygen tension by the VHL (von Hippel-Lindau) tumor suppressor protein but stabilized by hypoxia to activate an array of genes implicated in oxygen homeostasis including vascular endothelial growth factor.	Oxygen	167-173	vascular endothelial growth factor A	Homo sapiens	196-230
15039136-1	2004	Endothelial PAS domain protein-1 (EPAS1) regulates transcription of the genes encoding erythropoietin and vascular endothelial growth factor, which are important for maintaining oxygen homeostasis.	Oxygen	178-184	erythropoietin	Homo sapiens	87-101
15039136-1	2004	Endothelial PAS domain protein-1 (EPAS1) regulates transcription of the genes encoding erythropoietin and vascular endothelial growth factor, which are important for maintaining oxygen homeostasis.	Oxygen	178-184	vascular endothelial growth factor A	Homo sapiens	106-140
15271702-3	2004	In this study, we investigated the relationship between intraoperative changes in regional cerebral oxygen saturation (rSo(2)) and postoperative values of neuron-specific enolase (NSE) and S-100, which are specific variables that indicate cerebral disturbances due to hypoxia/ischemia.	Oxygen	100-106	enolase 2	Homo sapiens	155-178
15271702-3	2004	In this study, we investigated the relationship between intraoperative changes in regional cerebral oxygen saturation (rSo(2)) and postoperative values of neuron-specific enolase (NSE) and S-100, which are specific variables that indicate cerebral disturbances due to hypoxia/ischemia.	Oxygen	100-106	enolase 2	Homo sapiens	180-183
15120957-7	2004	In standard conditions (pH 7.4, pCO2 40 mmHg and temperature 37 degrees C), the partial oxygen pressure at half-saturation of haemoglobin (p50) was 30.0+/-1.3 mmHg for dogs and 34.1+/-1.8 mmHg for cats.	Oxygen	88-94	nuclear factor kappa B subunit 1	Homo sapiens	139-142
15321699-6	2004	Co-infusion of the oxygen-derived free radical scavenger vitamin C significantly increased baseline FBF from 2.0 +/- 0.5 to 2.5 +/- 0.7 (mL/min/100 mL forearm tissue (P &lt; 0.001)) and acetylcholine-stimulated FBF responses in patients with elevated CRP, but not in patients with low CRP serum levels.	Oxygen	19-25	C-reactive protein	Homo sapiens	251-254
15321699-6	2004	Co-infusion of the oxygen-derived free radical scavenger vitamin C significantly increased baseline FBF from 2.0 +/- 0.5 to 2.5 +/- 0.7 (mL/min/100 mL forearm tissue (P &lt; 0.001)) and acetylcholine-stimulated FBF responses in patients with elevated CRP, but not in patients with low CRP serum levels.	Oxygen	19-25	C-reactive protein	Homo sapiens	285-288
15339684-2	2004	One way of enhancing oxygen delivery is to take recombinant human erythropoietin (rHuEpo), which is an unethical and potentially dangerous practice.	Oxygen	21-27	erythropoietin	Homo sapiens	66-80
15304631-0	2004	Hydroxylation of HIF-1: oxygen sensing at the molecular level.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
15208263-3	2004	In this study, we demonstrate the actual role of a functional cross-talk between glial and neuronal cells expressing fALS mutant G93A-SOD1, where an increase in the production of reactive oxygen species occurs.	Oxygen	188-194	superoxide dismutase 1, soluble	Mus musculus	134-138
15123765-0	2004	Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.	Oxygen	72-78	aryl-hydrocarbon receptor	Mus musculus	18-29
15336911-7	2004	Furthermore, despite the fact that the p38 MAPK pathway was activated less strongly by GM-CSF, the p38 MAPK inhibitor SB203580 reduced GM-CSF-induced O2- production in the neutrophils of the elderly to levels similar to those obtained with PD98059.	Oxygen	150-152	mitogen-activated protein kinase 1	Homo sapiens	99-102
15336911-8	2004	TNF-alpha-triggered O2- production was not altered by ageing and in fact, a similar ERK1/2 or p38 MAPK activation was found in TNF-alpha-stimulated neutrophils from elderly and young individuals.	Oxygen	20-22	tumor necrosis factor	Homo sapiens	0-9
15235597-5	2004	Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension.	Oxygen	240-246	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-107
15235597-5	2004	Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension.	Oxygen	240-246	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-114
15300180-4	2004	METHODS: Hypoxia-inducible factor 1alpha (HIF-1alpha) ELISA was performed on MCF7 human breast cancer cells in hypoxia (1% O2) or normoxia (21% O2).	Oxygen	123-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
15280800-1	2004	EC-SOD catalyzes the dismutation of superoxide radical to hydrogen peroxide and oxygen in the interstitial spaces of tissues and in extracellular fluids (plasma, lymph, and synovial fluid).	Oxygen	80-86	superoxide dismutase 3	Homo sapiens	0-6
15166218-0	2004	Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.	Oxygen	16-22	nitric oxide synthase 3	Homo sapiens	50-83
15297737-3	2004	Since superoxide dismutase and catalase inhibited these reactions extensively, active oxygens such as superoxide and hydrogen peroxide were considered to be involved in the oxido-reductive reaction of human hemoglobin by pyrogallol.	Oxygen	86-93	catalase	Homo sapiens	31-39
15263953-1	2004	The formation constants of the ligand N,N,N",N"-tetrakis(carbamoylmethyl)-ethylenediamine suggest that the amide oxygen is a stronger Lewis base in water than the alcoholic oxygen, or water, and that part of the selectivity for Ca2+ over Mg2+ shown by calcium-binding proteins such as calmodulin or annexin may be due to the higher affinity of Ca2+ for the O-donor of the Ca-binding amide groups present in such proteins.	Oxygen	113-119	calmodulin 1	Homo sapiens	285-295
15131110-12	2004	Taken together, these data suggest that endogenous NCB5OR is a soluble NAD(P)H reductase preferentially reducing substrate(s) rather than transferring electrons to molecular oxygen and therefore not an NAD(P)H oxidase for superoxide production.	Oxygen	174-180	cytochrome b5 reductase 4	Homo sapiens	51-57
15303088-18	2004	Total VEGF protein was increased to a greater degree by repeated fluctuations in oxygen compared to a single cycle of oxygen.	Oxygen	81-87	vascular endothelial growth factor A	Homo sapiens	6-10
15303088-18	2004	Total VEGF protein was increased to a greater degree by repeated fluctuations in oxygen compared to a single cycle of oxygen.	Oxygen	118-124	vascular endothelial growth factor A	Homo sapiens	6-10
15236589-7	2004	Collectively, the data indicate that VHR and likely all DSPs can match leaving-group potential with the timing of the proton transfer to the ester oxygen, such that diverse aryl and alkyl phosphoesters are turned over with similar catalytic efficiency.	Oxygen	147-153	dual specificity phosphatase 3	Homo sapiens	37-40
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Oxygen	192-198	Cti6p	Saccharomyces cerevisiae S288C	28-32
15131110-3	2004	We initially reported human NCB5OR to be a 487-residue soluble protein that reduces cytochrome c, methemoglobin, ferricyanide, and molecular oxygen in vitro.	Oxygen	141-147	cytochrome b5 reductase 4	Homo sapiens	28-34
15131110-10	2004	However, both full-length and truncated NCB5OR produce superoxide from oxygen with slow turnover rates: kcat = approximately 0.05 and approximately 1 s(-1), respectively.	Oxygen	71-77	cytochrome b5 reductase 4	Homo sapiens	40-46
15223330-7	2004	The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.	Oxygen	73-79	Peptidoglycan recognition protein LB	Drosophila melanogaster	151-158
15220933-4	2004	Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35.	Oxygen	18-24	Cyclic nucleotide-gated cation channel	Caenorhabditis elegans	92-97
15220933-4	2004	Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35.	Oxygen	18-24	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	150-156
15220933-5	2004	The GCY-35 haem domain binds molecular oxygen, unlike the haem domains of classical nitric-oxide-regulated guanylate cyclases.	Oxygen	39-45	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	4-10
15220933-6	2004	GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans.	Oxygen	25-31	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	0-6
15220933-6	2004	GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans.	Oxygen	25-31	Cyclic nucleotide-gated cation channel	Caenorhabditis elegans	11-16
15220933-7	2004	Social feeding and related behaviours occur only when oxygen exceeds C. elegans" preferred level, and require gcy-35 activity.	Oxygen	54-60	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	110-116
15220933-8	2004	Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments.	Oxygen	58-64	Guanylate cyclase domain-containing protein;Soluble guanylate cyclase gcy-35	Caenorhabditis elegans	25-31
15123662-3	2004	We recently demonstrated that NADPH oxidase activation involves sequential interactions between Rac and the flavocytochrome b(558) and p67(phox) oxidase components to regulate electron transfer from NADPH to molecular oxygen.	Oxygen	218-224	AKT serine/threonine kinase 1	Homo sapiens	96-99
15240811-9	2004	AAV-mediated overexpression of AIP in primary cortical- hippocampal neurons markedly reduced cell death and caspase-3 activation triggered by protein kinase C inhibition, DNA damage, or oxygen- glucose deprivation.	Oxygen	186-192	APAF1 interacting protein	Rattus norvegicus	31-34
15178641-4	2004	Interestingly, upregulation of VEGF was not mediated by hypoxia-inducible transcription factor-1 (HIF-1) as indicated by only a weak expression of the oxygen-sensitive alpha-subunit of HIF-1 in the skin of SSc patients.	Oxygen	151-157	vascular endothelial growth factor A	Homo sapiens	31-35
15178641-4	2004	Interestingly, upregulation of VEGF was not mediated by hypoxia-inducible transcription factor-1 (HIF-1) as indicated by only a weak expression of the oxygen-sensitive alpha-subunit of HIF-1 in the skin of SSc patients.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	185-190
15296452-3	2004	The results of this study show that increasing the G-Hb molar ratio elicits a general decrease in the P50 (partial pressure of oxygen at which Hb is half saturated with oxygen) and cooperativity and a simultaneous increase in the weight averaged molecular weight (Mw) of the PolyHb dispersion and methemoglobin (MetHb) level.	Oxygen	127-133	nuclear factor kappa B subunit 1	Homo sapiens	102-105
15013953-0	2004	Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice.	Oxygen	23-29	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	73-103
15013953-8	2004	Furthermore, 2 h of oxygen and glucose deprivation (OGD) led to an approximately 80% increase in pH(i) recovery rate in NHE1(+/+) astrocytes.	Oxygen	20-26	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	120-124
15296452-3	2004	The results of this study show that increasing the G-Hb molar ratio elicits a general decrease in the P50 (partial pressure of oxygen at which Hb is half saturated with oxygen) and cooperativity and a simultaneous increase in the weight averaged molecular weight (Mw) of the PolyHb dispersion and methemoglobin (MetHb) level.	Oxygen	169-175	nuclear factor kappa B subunit 1	Homo sapiens	102-105
15190211-1	2004	In hypoxic cells, HIF-1alpha escapes from oxygen-dependent proteolysis and binds to the hypoxia-responsive element (HRE) for transcriptional activation of target genes involved in angiogenesis and glycolysis.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
15233838-5	2004	Thereafter, a rise in O(2) of 223 +/- 123 ml min(-1) (consistent with the mathematical model, 259 +/- 126 ml min(-1)) was observed between minutes 2 and 10.	Oxygen	22-26	CD59 molecule (CD59 blood group)	Homo sapiens	45-51
15233838-5	2004	Thereafter, a rise in O(2) of 223 +/- 123 ml min(-1) (consistent with the mathematical model, 259 +/- 126 ml min(-1)) was observed between minutes 2 and 10.	Oxygen	22-26	CD59 molecule (CD59 blood group)	Homo sapiens	109-115
15229867-10	2004	In erythrocytes of many lower vertebrates, NHE1 is activated during hypoxia and is an important modulator of hemoglobin oxygen affinity.	Oxygen	120-126	solute carrier family 9 member A1	Homo sapiens	43-47
15223825-0	2004	Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice.	Oxygen	63-69	prolactin	Homo sapiens	49-53
15223825-4	2004	16K hPRL inhibited retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	66-72	prolactin	Homo sapiens	4-8
15223825-9	2004	CONCLUSIONS: Intravitreal administration of 16K hPRL inhibited neovascularization in the mouse model of oxygen-induced retinopathy.	Oxygen	104-110	prolactin	Homo sapiens	48-52
15199099-3	2004	HIF-1alpha is rapidly degraded by a proteasome under normal oxygen (21% O2) conditions, mainly as a result of prolyl hydroxylation needed for protein destabilization.	Oxygen	60-66	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	0-10
15199099-3	2004	HIF-1alpha is rapidly degraded by a proteasome under normal oxygen (21% O2) conditions, mainly as a result of prolyl hydroxylation needed for protein destabilization.	Oxygen	72-74	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	0-10
15250052-5	2004	It is hypothesized in this research that 1) by mimicking facilitated oxygen transport in avascular tissues, the immunoprotected islets release a higher amount of insulin, recover their intrinsic biphasic release pattern, and prolong their life-span, and 2) insulinotropic agents further promote insulin secretion from islets.	Oxygen	69-75	insulin	Homo sapiens	162-169
15280069-8	2004	RESULTS: Although IRL1620 and endothelin-1 increased oxygen consumption in isolated hepatocytes, in intact liver, endothelin decreased oxygen consumption while IRL1620 produced no change.	Oxygen	53-59	endothelin 1	Homo sapiens	30-42
15246585-6	2004	RESULTS: Vasopressin generated higher cortical cerebral blood flow (P &lt; 0.001) and lower cerebral oxygen extraction (P &lt; 0.001) during CPR compared to continuous adrenaline.	Oxygen	101-107	vasopressin	Sus scrofa	9-20
15246585-8	2004	CONCLUSIONS: In this experimental model, vasopressin caused a greater increase in cortical cerebral blood flow and lower cerebral oxygen extraction during CPR compared to continuous adrenaline.	Oxygen	130-136	vasopressin	Sus scrofa	41-52
15454064-0	2004	[High expression of catalase inhibiting of activated oxygen-induced apoptosis of len epithelial cell apoptosis].	Oxygen	53-59	catalase	Homo sapiens	20-28
15228594-1	2004	Hypoxia inducible factor (HIF-1)-1alpha is a specific, oxygen-sensitive protein that regulates the activity of HIF-1, a transcriptional factor that increases after cerebral ischemia and may either promote or prevent neuronal survival.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
15228594-1	2004	Hypoxia inducible factor (HIF-1)-1alpha is a specific, oxygen-sensitive protein that regulates the activity of HIF-1, a transcriptional factor that increases after cerebral ischemia and may either promote or prevent neuronal survival.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-116
15256062-6	2004	Together, the data show that overexpression of DDAH results in C6 gliomas that are more hypoxic compared to wild-type tumors, and point strongly to an inverse relationship of tumor oxygenation and angiogenesis in vivo--a concept now being supported by the enhanced understanding of oxygen sensing at the molecular level.	Oxygen	181-187	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	47-51
15250052-5	2004	It is hypothesized in this research that 1) by mimicking facilitated oxygen transport in avascular tissues, the immunoprotected islets release a higher amount of insulin, recover their intrinsic biphasic release pattern, and prolong their life-span, and 2) insulinotropic agents further promote insulin secretion from islets.	Oxygen	69-75	insulin	Homo sapiens	257-264
15130787-0	2004	Kinetics of oxygen binding to ferrous myeloperoxidase.	Oxygen	12-18	myeloperoxidase	Homo sapiens	38-53
15235573-4	2004	METHODS: OIR was produced by exposure of neonatal mice to 75% oxygen between postnatal days 7 and 12 (P7-P12).	Oxygen	62-68	polymerase (DNA-directed), delta 4	Mus musculus	105-108
15199114-6	2004	We used an enzyme-linked immunosorbent assay to measure VEGF secretion by transfected cells cultured in hypoxic (1% O2) or nonhypoxic (20% O2) conditions.	Oxygen	116-118	vascular endothelial growth factor A	Homo sapiens	56-60
15199114-6	2004	We used an enzyme-linked immunosorbent assay to measure VEGF secretion by transfected cells cultured in hypoxic (1% O2) or nonhypoxic (20% O2) conditions.	Oxygen	139-141	vascular endothelial growth factor A	Homo sapiens	56-60
15205314-11	2004	Bax-deficient HCT116 cells were completely resistant to TRAIL regardless of oxygen content, demonstrating a pivotal role of Bax in TRAIL-induced apoptotic signaling.	Oxygen	76-82	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
15205314-11	2004	Bax-deficient HCT116 cells were completely resistant to TRAIL regardless of oxygen content, demonstrating a pivotal role of Bax in TRAIL-induced apoptotic signaling.	Oxygen	76-82	TNF superfamily member 10	Homo sapiens	131-136
15159288-7	2004	Two oxygen radical scavengers and the epidermal growth factor receptor (EGFR) antagonist AG1478 reduced Ang II-, Ald-, and combination-induced ERK1/2 phosphorylation.	Oxygen	4-10	angiotensinogen	Homo sapiens	104-110
15159288-7	2004	Two oxygen radical scavengers and the epidermal growth factor receptor (EGFR) antagonist AG1478 reduced Ang II-, Ald-, and combination-induced ERK1/2 phosphorylation.	Oxygen	4-10	mitogen-activated protein kinase 3	Homo sapiens	143-149
15172174-5	2004	iNOS activation is regulated mainly at the transcriptional level, but also at posttranscriptional, translational and postranslational levels through effects on protein stability, dimerization, phosphorylation, cofactor binding and availability of oxygen and L-arginine as substrates.	Oxygen	247-253	nitric oxide synthase 2	Homo sapiens	0-4
15215539-5	2004	A recent paper describes the presence of an inactive pool of SOD1 whose activation is wholly reliant on the presence of superoxide or oxygen and a specific copper-containing chaperone.	Oxygen	134-140	superoxide dismutase 1	Homo sapiens	61-65
15178343-1	2004	The recent identification of hypoxia-inducible-factor (HIF) prolyl hydroxylases (PHD1, 2, and 3), which modify HIF-1 alpha in an oxygen-dependent manner, provided an important link between oxygen availability and hypoxia-induced gene expression.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-122
15178343-1	2004	The recent identification of hypoxia-inducible-factor (HIF) prolyl hydroxylases (PHD1, 2, and 3), which modify HIF-1 alpha in an oxygen-dependent manner, provided an important link between oxygen availability and hypoxia-induced gene expression.	Oxygen	189-195	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-122
15142852-0	2004	Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression.	Oxygen	0-6	erythropoietin	Homo sapiens	51-65
15142852-2	2004	EPO is the main regulator of red blood cell production and more than 100 years of research on the regulation of EPO production have led to the identification of a widespread cellular oxygen sensing mechanism.	Oxygen	183-189	erythropoietin	Homo sapiens	0-3
15142852-2	2004	EPO is the main regulator of red blood cell production and more than 100 years of research on the regulation of EPO production have led to the identification of a widespread cellular oxygen sensing mechanism.	Oxygen	183-189	erythropoietin	Homo sapiens	112-115
15142852-4	2004	Meanwhile, it is known that HIF-1 controls more than 50 oxygen-dependent genes and is now recognized as the main regulator of oxygen homoeostasis in the body.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15142852-4	2004	Meanwhile, it is known that HIF-1 controls more than 50 oxygen-dependent genes and is now recognized as the main regulator of oxygen homoeostasis in the body.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15142852-9	2004	Understanding oxygen and tissue-specific regulation of EPO production is of high relevance for physiology.	Oxygen	14-20	erythropoietin	Homo sapiens	55-58
15144292-3	2004	Simulated oxygen uptake values between 200 and 350 ml x min(-1) were modelled.	Oxygen	10-16	CD59 molecule (CD59 blood group)	Homo sapiens	56-62
15144292-4	2004	The Biro-derived measurement of simulated O(2) uptake significantly underestimated the target value (mean difference -88.5 ml x min(-1), or -31.7%).	Oxygen	42-46	CD59 molecule (CD59 blood group)	Homo sapiens	128-134
15130787-3	2004	To investigate the reactivity of ferrous MPO with molecular oxygen, a stopped-flow kinetic analysis was performed.	Oxygen	60-66	myeloperoxidase	Homo sapiens	41-44
15130787-5	2004	At pH 7.0 and 25 degrees C, compound III formation (i.e., binding of dioxygen to ferrous MPO) occurs with a rate constant of (1.1+/-0.1) x 10(4)M(-1)s(-1).	Oxygen	69-77	myeloperoxidase	Homo sapiens	89-92
15130787-8	2004	The rate constant of dioxygen dissociation from compound III is much higher than conversion of compound III to ferric MPO (which is not affected by the oxygen concentration).	Oxygen	23-29	myeloperoxidase	Homo sapiens	118-121
15181371-9	2004	In conclusion, we demonstrate that epsilonPKC activation after IPC/PPC is essential for neuroprotection against oxygen/glucose deprivation in organotypic slice cultures and that the ERK pathway is downstream to epsilonPKC.	Oxygen	112-118	mitogen-activated protein kinase 1	Homo sapiens	182-185
14960485-2	2004	In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor.	Oxygen	7-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-56
14960485-2	2004	In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor.	Oxygen	7-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-63
14960485-2	2004	In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor.	Oxygen	7-13	vascular endothelial growth factor A	Homo sapiens	156-190
14960485-2	2004	In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor.	Oxygen	7-13	vascular endothelial growth factor A	Homo sapiens	192-196
15084514-1	2004	Hypoxia-inducible factor (HIF)-1alpha, a master regulator of oxygen homeostasis, regulates genes crucial for cell growth and survival.	Oxygen	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
15084514-3	2004	The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specific recognition of hydroxylated Pro-402 or Pro-564, both of which are modified by the oxygen-dependent HIF prolyl hydroxylases (PHDs/HPHs).	Oxygen	164-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
15084514-9	2004	Furthermore, mutation of Leu-574 disrupts the binding of PHD2/HPH2, a key prolyl hydroxylase for oxygen-dependent proteolysis of HIF-1alpha.	Oxygen	97-103	egl-9 family hypoxia inducible factor 1	Homo sapiens	57-61
15084514-9	2004	Furthermore, mutation of Leu-574 disrupts the binding of PHD2/HPH2, a key prolyl hydroxylase for oxygen-dependent proteolysis of HIF-1alpha.	Oxygen	97-103	egl-9 family hypoxia inducible factor 1	Homo sapiens	62-66
15084514-9	2004	Furthermore, mutation of Leu-574 disrupts the binding of PHD2/HPH2, a key prolyl hydroxylase for oxygen-dependent proteolysis of HIF-1alpha.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
14984367-4	2004	These enzymes are oxygen-, iron- and 2-oxoglutarate-dependent dioxygenases that hydroxylate key proline and asparagine residues in HIFalpha subunits.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-139
15149885-2	2004	METHODS: uPA monocyte expression was stimulated by either copper ions-oxidised or O2*-/HO* free radical-oxidised LDL.	Oxygen	82-84	plasminogen activator, urokinase	Homo sapiens	9-12
14988384-7	2004	During exercise, the young and older IL-6(-/-) mice had a reduced endurance and a progressive decrease in oxygen consumption compared with control mice.	Oxygen	106-112	interleukin 6	Mus musculus	37-41
15204834-2	2004	Interleukin (IL)-8 protein concentrations from homogenates of the premature lung rose significantly after hyperoxia (6.8 +/- 1.8 in 5% O2 to 45.7 +/- 21.3 pg/microg protein in 95% O2) but not in the term lung (15.9 +/- 6.7 to 20.4 +/- 4.3 pg/microg protein).	Oxygen	135-137	interleukin-8	Oryctolagus cuniculus	0-18
15204834-2	2004	Interleukin (IL)-8 protein concentrations from homogenates of the premature lung rose significantly after hyperoxia (6.8 +/- 1.8 in 5% O2 to 45.7 +/- 21.3 pg/microg protein in 95% O2) but not in the term lung (15.9 +/- 6.7 to 20.4 +/- 4.3 pg/microg protein).	Oxygen	180-182	interleukin-8	Oryctolagus cuniculus	0-18
15500003-4	2004	CA IX expression is upregulated by Hypoxia Inducible Factor-1 (HIF-1), which is negatively controlled by oxygen via wild type VHL protein and is also regulated by the cell redox state.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-61
15500003-4	2004	CA IX expression is upregulated by Hypoxia Inducible Factor-1 (HIF-1), which is negatively controlled by oxygen via wild type VHL protein and is also regulated by the cell redox state.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-68
15470316-6	2004	RESULTS: Mean maximal oxygen uptake was 73.7+/-7.0 and 47.4+/-7.5 ml x kg(-1) x min(-1) in the 2 groups, respectively.	Oxygen	22-28	CD59 molecule (CD59 blood group)	Homo sapiens	80-86
15223607-3	2004	Excess tumour necrosis factor (TNF)-alpha and NO* react with O2*- and cause further antioxidant depletion with an increase in mutation frequency by H2O2.	Oxygen	61-63	tumor necrosis factor	Homo sapiens	7-41
15173538-7	2004	Significant positive correlations were found between log CRP levels and AHI (r =.53) and arousal index (r =.28), whereas an inverse correlation was found between the lowest nocturnal arterial oxygen saturation and log CRP levels (r = -.47).	Oxygen	192-198	C-reactive protein	Homo sapiens	218-221
15116219-1	2004	A series of cobalt-free and low cost perovskite oxygen permeable membranes based on BaCe(x)Fe(1-x)O(3-delta)(BCF) oxides was successfully synthesized and the membrane showed both high oxygen permeability and high stability under reductive atmosphere, which will be most suitable for constructing a membrane reactor for selective oxidation of light hydrocarbons to syngas or high value corresponding oxygenates.	Oxygen	48-54	beta-secretase 1	Homo sapiens	84-88
15140065-15	2004	However, our data suggests that tyrosinase-related protein-1, rather than tyrosinase, facilitates toxicity, possibly by catalytic conversion of the compounds, which results in the generation of radical oxygen species.	Oxygen	202-208	tyrosinase related protein 1	Homo sapiens	32-60
15283163-7	2004	Exposure of growth-arrested HRCs with hypoxia (1% O2) or TNF-alpha (10 ng/ml) for 24 hours increased the secretion rate of PAI-1 protein by about 2.0-fold, while 24-hour treatment with high glucose (450 mg/dl) did not increase PAI-1 secretion at all, compared with that of the control cells under normal glucose (100 mg/dl) and normoxia (18% O2).	Oxygen	342-344	tumor necrosis factor	Homo sapiens	57-66
15154797-20	2004	The rearrangement of trans-HCOH (carbon bound) to CH(2)O (oxygen bound) on ZnO(0001) was calculated to be the overall barrier of the MSR reaction.	Oxygen	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	133-136
15147208-0	2004	Tyrosine B10 inhibits stabilization of bound carbon monoxide and oxygen in soybean leghemoglobin.	Oxygen	65-71	leghemoglobin A	Glycine max	83-96
15147208-6	2004	Thus, high oxygen affinity in leghemoglobin is established by a favorable staggered geometry of the proximal histidine.	Oxygen	11-17	leghemoglobin A	Glycine max	30-43
15147208-8	2004	If hydrogen bonding from His(E7) were as strong as it is in mammalian myoglobin, the resultant ultrahigh affinity of leghemoglobin would prevent oxygen transport in root nodules.	Oxygen	145-151	leghemoglobin A	Glycine max	117-130
18950090-4	2004	The transformation from chemically disordered fcc to chemically ordered L10 phase is achieved by annealing at 650 degrees C for 30 min in Ar atmosphere where the oxygen level is less than 1 ppm.	Oxygen	162-168	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	72-75
15149544-9	2004	CONCLUSIONS: These unexpected findings contrast with previous results in human primary cells using Epo at supraphysiological concentrations and open new doors to eventually understanding how low Epo concentrations mediate the moderate proliferation of erythroid progenitors under homeostatic blood oxygen levels.	Oxygen	298-304	erythropoietin	Homo sapiens	195-198
15256117-5	2004	RESULTS: The levels of HIF-1alpha mRNA changed significantly in response to different oxygen concentrations and an addition of genistein in SW480 cells.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
15004019-0	2004	Evidence of two distinct oxygen complexes of reduced endothelial nitric oxide synthase.	Oxygen	25-31	nitric oxide synthase 3	Homo sapiens	53-86
15004019-1	2004	Oxygen binding to the oxygenase domain of reduced endothelial nitric oxide synthase (eNOS) results in two distinct species differing in their Soret and visible absorbance maxima and in their capacity to exchange oxygen by CO.	Oxygen	0-6	nitric oxide synthase 3	Homo sapiens	50-83
15004019-1	2004	Oxygen binding to the oxygenase domain of reduced endothelial nitric oxide synthase (eNOS) results in two distinct species differing in their Soret and visible absorbance maxima and in their capacity to exchange oxygen by CO.	Oxygen	22-28	nitric oxide synthase 3	Homo sapiens	50-83
15071503-2	2004	HIF-1alpha, a basic helix-loop-helix PAS transcription factor, acts as a master regulator of oxygen homeostasis by upregulating various genes under low oxygen tension.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
15071503-2	2004	HIF-1alpha, a basic helix-loop-helix PAS transcription factor, acts as a master regulator of oxygen homeostasis by upregulating various genes under low oxygen tension.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
15252628-4	2004	DFT studies are also performed to gain an insight into the stabilization of the lower oxidation state of the CoL2(2+/3+) couple in order to understand the different reactivity of the Co(II) complexes towards dioxygen.	Oxygen	208-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
15116219-1	2004	A series of cobalt-free and low cost perovskite oxygen permeable membranes based on BaCe(x)Fe(1-x)O(3-delta)(BCF) oxides was successfully synthesized and the membrane showed both high oxygen permeability and high stability under reductive atmosphere, which will be most suitable for constructing a membrane reactor for selective oxidation of light hydrocarbons to syngas or high value corresponding oxygenates.	Oxygen	184-190	beta-secretase 1	Homo sapiens	84-88
15080932-3	2004	(R)-N-Hydroxy-N-sulfamoyl-beta-phenylalanine (8) was shown to be also a potent CPA inhibitor (Ki = 39 microM), the high potency of which may be ascribed to the involvement of the hydroxyl in the binding of CPA, most likely forming bidentate coordinative bonds to the zinc ion in CPA together with the sulfamoyl oxygen atom.	Oxygen	311-317	carboxypeptidase A1	Homo sapiens	79-82
14693680-9	2004	Severe hypoxia (3% O2) potentiated the growth-promoting effect of MCP-1, which was able to significantly induce cell proliferation even at a concentration as low as 0.1 pg/ml.	Oxygen	19-21	mast cell protease 1-like 1	Rattus norvegicus	66-71
15144951-3	2004	Following radiotherapy, tumor reoxygenation leads to: (1) nuclear accumulation of HIF-1 in response to reactive oxygen, and (2) enhanced translation of HIF-1-regulated transcripts secondary to stress granule depolymerization.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
15144951-3	2004	Following radiotherapy, tumor reoxygenation leads to: (1) nuclear accumulation of HIF-1 in response to reactive oxygen, and (2) enhanced translation of HIF-1-regulated transcripts secondary to stress granule depolymerization.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-157
15140018-0	2004	TNF-alpha suppresses dendritic cell death and the production of reactive oxygen intermediates induced by plasma withdrawal.	Oxygen	73-79	tumor necrosis factor	Homo sapiens	0-9
15144216-5	2004	Both peroxynitrite and cytochrome c were able to initiate oxygen consumption by SA, which was followed by polarimetric and chemiluminescence measurements.	Oxygen	58-64	cytochrome c, somatic	Homo sapiens	23-35
15044855-3	2004	Normal levels of Hph are required for cellular growth, demonstrating that Hph, in addition to its known function in the cellular response low oxygen levels, regulates growth.	Oxygen	142-148	HIF prolyl hydroxylase	Drosophila melanogaster	17-20
15044855-3	2004	Normal levels of Hph are required for cellular growth, demonstrating that Hph, in addition to its known function in the cellular response low oxygen levels, regulates growth.	Oxygen	142-148	HIF prolyl hydroxylase	Drosophila melanogaster	74-77
15044855-4	2004	Since Hph"s hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.	Oxygen	46-52	HIF prolyl hydroxylase	Drosophila melanogaster	6-9
15044855-4	2004	Since Hph"s hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.	Oxygen	142-148	HIF prolyl hydroxylase	Drosophila melanogaster	6-9
15237857-1	2004	Cytochrome P450 (CYP) enzymes in the brain may have a role in the activation or inactivation of centrally acting drugs, in the metabolism of endogenous compounds, and in the generation of damaging toxic metabolites and/or oxygen stress.	Oxygen	222-228	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
15237857-1	2004	Cytochrome P450 (CYP) enzymes in the brain may have a role in the activation or inactivation of centrally acting drugs, in the metabolism of endogenous compounds, and in the generation of damaging toxic metabolites and/or oxygen stress.	Oxygen	222-228	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
15116005-0	2004	Insulin-like growth factor 1 improves the relationship between systemic oxygen consumption and delivery in piglets after cardiopulmonary bypass.	Oxygen	72-78	insulin like growth factor 1	Homo sapiens	0-28
15170745-6	2004	Multiple-stage dissociation experiments suggest that [M - H(2)O + Cat](+) is not [b(4) - 1 + Cat](+) arising from the loss of H(2)O from the C-terminus, but may instead be a species that forms via a mechanism involving the elimination of an oxygen atom from an amide group.	Oxygen	241-247	catalase	Homo sapiens	66-69
15165135-11	2004	Further study revealed that 1 selectively blocked the induction of HIF-1alpha protein, the oxygen regulated HIF-1 subunit that determines HIF-1 activity.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
15165135-11	2004	Further study revealed that 1 selectively blocked the induction of HIF-1alpha protein, the oxygen regulated HIF-1 subunit that determines HIF-1 activity.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-113
15124263-5	2004	O2- production was measured by cytochrome C reduction after incubation of 106 synovial fluid (SF) cells with or without phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMLP) or opsonized zymosan.	Oxygen	0-2	cytochrome c, somatic	Homo sapiens	31-43
15124263-5	2004	O2- production was measured by cytochrome C reduction after incubation of 106 synovial fluid (SF) cells with or without phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMLP) or opsonized zymosan.	Oxygen	0-2	formyl peptide receptor 1	Homo sapiens	192-196
15116005-1	2004	OBJECTIVE: We sought to assess the effects of insulin-like growth factor 1 on the balance between systemic oxygen consumption and oxygen delivery after cardiopulmonary bypass in piglets.	Oxygen	107-113	insulin like growth factor 1	Homo sapiens	46-74
15116005-1	2004	OBJECTIVE: We sought to assess the effects of insulin-like growth factor 1 on the balance between systemic oxygen consumption and oxygen delivery after cardiopulmonary bypass in piglets.	Oxygen	130-136	insulin like growth factor 1	Homo sapiens	46-74
15116005-8	2004	RESULTS: Relative to the control group, intravenous infusion of insulin-like growth factor 1 significantly reduced oxygen consumption (P =.02) and increased cardiac output (P =.016) and oxygen delivery (P =.049) during the first 6 hours after surgery with hypothermic cardiopulmonary bypass.	Oxygen	115-121	insulin like growth factor 1	Homo sapiens	64-92
15116005-8	2004	RESULTS: Relative to the control group, intravenous infusion of insulin-like growth factor 1 significantly reduced oxygen consumption (P =.02) and increased cardiac output (P =.016) and oxygen delivery (P =.049) during the first 6 hours after surgery with hypothermic cardiopulmonary bypass.	Oxygen	186-192	insulin like growth factor 1	Homo sapiens	64-92
15116005-10	2004	CONCLUSIONS: Intravenous infusion of insulin-like growth factor 1 improved oxygen transport by reducing oxygen consumption as well as increasing cardiac output and oxygen delivery during the first 6 hours after cardiopulmonary bypass in piglets.	Oxygen	75-81	insulin like growth factor 1	Homo sapiens	37-65
15116005-10	2004	CONCLUSIONS: Intravenous infusion of insulin-like growth factor 1 improved oxygen transport by reducing oxygen consumption as well as increasing cardiac output and oxygen delivery during the first 6 hours after cardiopulmonary bypass in piglets.	Oxygen	104-110	insulin like growth factor 1	Homo sapiens	37-65
15116005-10	2004	CONCLUSIONS: Intravenous infusion of insulin-like growth factor 1 improved oxygen transport by reducing oxygen consumption as well as increasing cardiac output and oxygen delivery during the first 6 hours after cardiopulmonary bypass in piglets.	Oxygen	104-110	insulin like growth factor 1	Homo sapiens	37-65
19621736-0	2004	[Catalase and glutathione-peroxidase: qualitatively different correlations with the rate of oxygen consumption].	Oxygen	92-98	catalase	Mus musculus	1-9
14718647-7	2004	When cells were prelabeled with N-acetyl-cysteine (NAC), a substrate for glutathione synthesis, and catalase (CAT), the oxygen free radical scavenger, a significant reduction in cytogenetic damage was observed.	Oxygen	120-126	catalase	Homo sapiens	100-108
14718647-7	2004	When cells were prelabeled with N-acetyl-cysteine (NAC), a substrate for glutathione synthesis, and catalase (CAT), the oxygen free radical scavenger, a significant reduction in cytogenetic damage was observed.	Oxygen	120-126	catalase	Homo sapiens	110-113
15102952-1	2004	Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1:1 stoichiometry of oxygen consumption to NADH oxidation with the production of hydrogen peroxide.	Oxygen	178-184	NAD(P)H quinone dehydrogenase 1	Homo sapiens	45-77
15102952-1	2004	Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1:1 stoichiometry of oxygen consumption to NADH oxidation with the production of hydrogen peroxide.	Oxygen	178-184	NAD(P)H quinone dehydrogenase 1	Homo sapiens	79-83
19621736-1	2004	Correlative relations of the liver supernatant enzymatic activity of catalase (CAT) and glutathione-peroxidase (GP) with the velocities of oxygen consumption (VO2) and carbon dioxide exhalation (VCO2) were analyzed by the two- and three-dimensional linear and non-linear statistical methods in mice.	Oxygen	139-145	catalase	Mus musculus	69-77
19621736-1	2004	Correlative relations of the liver supernatant enzymatic activity of catalase (CAT) and glutathione-peroxidase (GP) with the velocities of oxygen consumption (VO2) and carbon dioxide exhalation (VCO2) were analyzed by the two- and three-dimensional linear and non-linear statistical methods in mice.	Oxygen	139-145	catalase	Mus musculus	79-82
14966128-5	2004	Examination of a series of wild type and mutant Stat3 proteins demonstrated loss of binding to pYXXQ-containing peptides only in Stat3 mutated at Lys-591 or Arg-609, whose side chains interact with the Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the +3 Gln side chain when the peptide ligand assumes a beta-turn.	Oxygen	280-286	signal transducer and activator of transcription 3	Homo sapiens	48-53
15130309-2	2004	METHODS: Culturing human lung adenocarcinoma A549 cell in hypoxia (2%O2) for 24 h, the expression of hypoxia inducible factor-1alpha, P-gp and multidrug resistance protein was detected by using immunohistochemistry, and after action of adriamycin or cisplatin in hypoxia (2%O2) for 24, the cell survival rate was detected by MTT.	Oxygen	69-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-132
14762718-4	2004	We conclude from these findings that the expression of TPI is regulated via the HIF pathway and thus belongs to the family of classic oxygen-regulated genes.	Oxygen	134-140	triosephosphate isomerase 1	Homo sapiens	55-58
15130309-2	2004	METHODS: Culturing human lung adenocarcinoma A549 cell in hypoxia (2%O2) for 24 h, the expression of hypoxia inducible factor-1alpha, P-gp and multidrug resistance protein was detected by using immunohistochemistry, and after action of adriamycin or cisplatin in hypoxia (2%O2) for 24, the cell survival rate was detected by MTT.	Oxygen	274-276	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-132
14764593-0	2004	Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-121
15064408-0	2004	Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	77-103
14761967-8	2004	Mutant eNOS lacking a pentabasic amino acid sequence within the autoinhibitory domain (residues 628-632 of the bovine eNOS) showed dramatically reduced binding to the mitochondrial but not to the plasma membrane, which was associated with increased oxygen consumption.	Oxygen	249-255	nitric oxide synthase 3	Bos taurus	7-11
14761967-8	2004	Mutant eNOS lacking a pentabasic amino acid sequence within the autoinhibitory domain (residues 628-632 of the bovine eNOS) showed dramatically reduced binding to the mitochondrial but not to the plasma membrane, which was associated with increased oxygen consumption.	Oxygen	249-255	nitric oxide synthase 3	Bos taurus	118-122
15044079-5	2004	In addition, oxygen-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation).	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
14726529-8	2004	HIF-1alpha co-immunoprecipitated with Hsp90/Hsp70 and direct binding of Hsp70 to the oxygen-dependent degradation domain (ODD) of HIF-1alpha was proven by a pull-down assay and a peptide array.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
14761947-5	2004	Endogenously produced extracellular ATP-enhanced mTOR-dependent uptake of glucose (3467 +/- 102 cpm/mg protein in 95% oxygen versus 2100 +/- 112 cpm/mg protein in control).	Oxygen	118-124	mechanistic target of rapamycin kinase	Homo sapiens	49-53
15069703-2	2004	In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic adaptation to low oxygen and promotes survival.	Oxygen	241-247	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
14726529-3	2004	In addition, it became apparent that Hsp90 protects HIF-1alpha from oxygen-independent degradation.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
14963632-1	2004	The catalytic reaction of catalase was investigated, by means of a Clark oxygen sensor, in the presence of various concentrations of acetylsalicylic acid.	Oxygen	73-79	catalase	Homo sapiens	26-34
15064408-3	2004	Data presented here are consistent with a previously uncharacterized function for CCS in the SOD1 pathway, namely mediating enzyme activation in response to increases in oxygen tension.	Oxygen	170-176	superoxide dismutase 1	Homo sapiens	93-97
15064408-6	2004	This CCS function provides oxidant-responsive posttranslational regulation of SOD1 activity and may be relevant to a wide array of physiological stresses that involve a sudden elevation of oxygen availability.	Oxygen	189-195	superoxide dismutase 1	Homo sapiens	78-82
14613480-7	2004	Conversely, in hypoxia (13% O2 for 1-2 h), BHT and Delta P ACO2 were reduced proportionally.	Oxygen	28-30	aconitase 2	Homo sapiens	59-63
15181463-4	2004	Before and for 67 min after the fatigue period, muscles contracted at 0.6 contractions x min(-1) in 95% oxygen - 5% carbon dioxide (hyperoxia).	Oxygen	104-110	CD59 molecule (CD59 blood group)	Homo sapiens	89-95
15030976-5	2004	The iron-induced cell injury was oxygen-dependent, and although it was not inhibitable by extracellular catalase, it was strongly inhibited by the novel membrane-permeable catalase mimic TAA-1/Fe.	Oxygen	33-39	catalase	Rattus norvegicus	172-180
15115770-3	2004	Hydrogen peroxide is converted to water and oxygen by catalase.	Oxygen	44-50	catalase	Homo sapiens	54-62
15131912-4	2004	Vasopressin, like epinephrine, promotes selective but potent vasoconstriction of smooth muscle, but unlike epinephrine, without the potentially harmful side effects of increasing myocardial workload, therefore increasing oxygen demand and subsequent worsening of cardiac function.	Oxygen	221-227	arginine vasopressin	Homo sapiens	0-11
15093994-10	2004	Inflammatory cytokine IL-6, but not anti-inflammatory cytokine Il-10, levels correlated significantly with the oxygen stress index.	Oxygen	111-117	interleukin 6	Homo sapiens	22-26
15024076-3	2004	Oxygen deprivation of human colon cancer cells in vitro provoked decreased mRNA and protein levels of proapoptotic Bid and Bad.	Oxygen	0-6	BH3 interacting domain death agonist	Homo sapiens	115-118
15064585-1	2004	PURPOSE: The aim of the study was to demonstrate whether changes in the charge pattern of urinary human erythropoietin (u-hEPO) from well-trained athletes before, during and after controlled administration of recombinant human EPO (r-hEPO) could be related to altered levels of hemoglobin (Hb), hematocrit (Hct), soluble transferrin receptor (sTfR) and maximal oxygen uptake (VO2max).	Oxygen	361-367	erythropoietin	Homo sapiens	227-238
15024076-5	2004	Oxygen deprivation resulted in proteosome-independent decreased expression of Bax in vitro, consistent with a reduction in global translation efficiency.	Oxygen	0-6	BCL2 associated X, apoptosis regulator	Homo sapiens	78-81
15233159-0	2004	Erythropoietin production can be enhanced by normobaric oxygen breathing in healthy humans.	Oxygen	56-62	erythropoietin	Homo sapiens	0-14
15023385-3	2004	Oxygen is an important modulator of gene expression and this regulation occurs largely through the activation of the transcriptional complex hypoxia-inducible factor-1 (HIF-1).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-167
15023385-3	2004	Oxygen is an important modulator of gene expression and this regulation occurs largely through the activation of the transcriptional complex hypoxia-inducible factor-1 (HIF-1).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-174
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	34-40	interleukin 1 beta	Rattus norvegicus	108-116
14691445-5	2004	When RCC4 cells expressing C-terminal truncations of VHL were exposed to graded hypoxia, differences in the induction of HIF-1alpha were observed in comparison with full-length VHL, with a shift in the maximal induction of HIF-1alpha to a higher oxygen tension.	Oxygen	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-233
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	34-40	tumor necrosis factor	Rattus norvegicus	235-244
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	34-40	interleukin 6	Rattus norvegicus	249-253
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	42-44	interleukin 1 beta	Rattus norvegicus	108-116
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	42-44	tumor necrosis factor	Rattus norvegicus	235-244
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	42-44	interleukin 6	Rattus norvegicus	249-253
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	178-180	tumor necrosis factor	Rattus norvegicus	235-244
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	178-180	interleukin 6	Rattus norvegicus	249-253
15001269-7	2004	RESULTS: In both cell lines, weak HIF-1 alpha expression was observed at 20% O(2) and after 10 min of hypoxia.	Oxygen	77-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-45
14994344-5	2004	By employing stable transfectants that expressed GLUT8-GFP, the effect of insulin and insulin-like growth factor-I, potassium chloride (depolarized state), and 3% oxygen on translocation of GLUT8 to the plasma membrane of N2A cells was examined immunohistochemically and by subfractionation, followed by Western blot analysis.	Oxygen	163-169	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	190-195
14985219-7	2004	RESULTS: Significant treatment effects were observed for time to complete the 15-km time trial, work rate, and percentage of maximal oxygen uptake in subjects with a baseline serum transferrin receptor concentration &gt; 8.0 mg/L.	Oxygen	133-139	transferrin	Homo sapiens	181-192
15068290-1	2004	A novel flow-injection assay (FIA) system with a double line for catalase activity was constructed in which an oxidase is immobilized and the substrate is continuously pumped to reduce the dissolved oxygen and to generate a given level of hydrogen peroxide.	Oxygen	199-205	catalase	Homo sapiens	65-73
14617515-2	2004	We previously demonstrated that exposing respiratory epithelial cells to 95% oxygen (hyperoxia) synergistically increased tumor necrosis factor-alpha (TNF-alpha)-mediated activation of NF-kappaB and NF-kappaB-dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK).	Oxygen	77-83	tumor necrosis factor	Homo sapiens	122-149
14617515-2	2004	We previously demonstrated that exposing respiratory epithelial cells to 95% oxygen (hyperoxia) synergistically increased tumor necrosis factor-alpha (TNF-alpha)-mediated activation of NF-kappaB and NF-kappaB-dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK).	Oxygen	77-83	tumor necrosis factor	Homo sapiens	151-160
14617515-2	2004	We previously demonstrated that exposing respiratory epithelial cells to 95% oxygen (hyperoxia) synergistically increased tumor necrosis factor-alpha (TNF-alpha)-mediated activation of NF-kappaB and NF-kappaB-dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK).	Oxygen	77-83	nuclear factor kappa B subunit 1	Homo sapiens	185-194
14617515-2	2004	We previously demonstrated that exposing respiratory epithelial cells to 95% oxygen (hyperoxia) synergistically increased tumor necrosis factor-alpha (TNF-alpha)-mediated activation of NF-kappaB and NF-kappaB-dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK).	Oxygen	77-83	nuclear factor kappa B subunit 1	Homo sapiens	199-208
15134336-3	2004	Of central importance is the activation of hypoxia-inducible factor-1 (HIF-1), a transcription factor complex that controls the expression of genes the products of which regulate glucose uptake and metabolism, vasotonus and angiogenesis, oxygen capacity of the blood as well as cell growth and death.	Oxygen	238-244	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-69
15134336-3	2004	Of central importance is the activation of hypoxia-inducible factor-1 (HIF-1), a transcription factor complex that controls the expression of genes the products of which regulate glucose uptake and metabolism, vasotonus and angiogenesis, oxygen capacity of the blood as well as cell growth and death.	Oxygen	238-244	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
15068290-2	2004	The catalase in a sample decomposed the hydrogen peroxide, and thus the increase in dissolved oxygen dependent on the activity was amperometrically monitored using a Clark-type oxygen electrode.	Oxygen	94-100	catalase	Homo sapiens	4-12
15068290-2	2004	The catalase in a sample decomposed the hydrogen peroxide, and thus the increase in dissolved oxygen dependent on the activity was amperometrically monitored using a Clark-type oxygen electrode.	Oxygen	177-183	catalase	Homo sapiens	4-12
15009163-3	2004	Although several proteins with signalling, assembling, transport, enzymatic function can be impaired in MCP, most frequently the activity of the respiratory chain (RC) protein complexes is primarily or secondarily affected, leading to impaired oxygen utilization and reduced energy production.	Oxygen	244-250	CD46 molecule	Homo sapiens	104-107
15050527-0	2004	Unusually weak oxygen binding, physical properties, partial sequence, autoxidation rate and a potential phosphorylation site of beluga whale (Delphinapterus leucas) myoglobin.	Oxygen	15-21	myoglobin	Equus caballus	165-174
14990507-1	2004	Cytochrome c oxidase mediates the final step of electron transfer reactions in the respiratory chain, catalyzing the transfer between cytochrome c and the molecular oxygen and concomitantly pumping protons across the inner mitochondrial membrane.	Oxygen	165-171	cytochrome c, somatic	Homo sapiens	0-12
14990507-1	2004	Cytochrome c oxidase mediates the final step of electron transfer reactions in the respiratory chain, catalyzing the transfer between cytochrome c and the molecular oxygen and concomitantly pumping protons across the inner mitochondrial membrane.	Oxygen	165-171	cytochrome c, somatic	Homo sapiens	134-146
15025502-1	2004	It has been proposed that the Met residue in the C-terminal domain of the Alzheimer"s disease beta-amyloid peptide (betaA) serves as a source of electrons for the Cu(II)-catalyzed reduction of molecular oxygen to hydrogen peroxide.	Oxygen	203-209	amyloid beta precursor protein	Homo sapiens	94-114
14980699-4	2004	We demonstrate here that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase (Sod2(-/+)) show increased incidence of spontaneous and handling-induced seizures that correlates with chronic mitochondrial oxidative stress (increased aconitase inactivation and 8-hydroxy-2"-deoxyguanosine formation in mitochondria) and diminished mitochondrial oxygen utilization.	Oxygen	372-378	superoxide dismutase 2, mitochondrial	Mus musculus	109-113
15016076-2	2004	The gene for amyloid precursor protein (APP), known to be involved in AD pathology, resides on chromosome 21 along with the gene for Cu/Zn superoxide dismutase (SOD1), a key enzyme in the metabolism of oxygen free radicals.	Oxygen	202-208	superoxide dismutase 1, soluble	Mus musculus	161-165
14712484-1	2004	We examined how ionizing radiation (IR) delivered under either severe hypoxia (&lt; 0.1% O2) or normoxia affects the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins 1, 2 and 4 in U87 human glioblastoma cells.	Oxygen	89-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-162
15129737-0	2004	Oxygen-copper (II) interplay in the repair of semi-oxidized urate by quercetin bound to human serum albumin.	Oxygen	0-6	albumin	Homo sapiens	94-107
15129738-5	2004	For EPR, potassium superoxide (KO2) was used as a source of O2- where qualitative results suggested that CpCpx and AcylCpCpx were SOD mimics, which catalyze the conversion of O2- to dioxygen and hydrogen peroxide (H2O2).	Oxygen	32-34	superoxide dismutase 1	Homo sapiens	130-133
15129738-5	2004	For EPR, potassium superoxide (KO2) was used as a source of O2- where qualitative results suggested that CpCpx and AcylCpCpx were SOD mimics, which catalyze the conversion of O2- to dioxygen and hydrogen peroxide (H2O2).	Oxygen	60-62	superoxide dismutase 1	Homo sapiens	130-133
15129738-5	2004	For EPR, potassium superoxide (KO2) was used as a source of O2- where qualitative results suggested that CpCpx and AcylCpCpx were SOD mimics, which catalyze the conversion of O2- to dioxygen and hydrogen peroxide (H2O2).	Oxygen	182-190	superoxide dismutase 1	Homo sapiens	130-133
15037806-1	2004	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15037806-1	2004	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15037806-2	2004	HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15037806-2	2004	HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
15037806-5	2004	In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-86
15037806-5	2004	In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-118
15037806-5	2004	In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-118
14657038-1	2004	We hypothesized that inhibition of nitric oxide synthase (NOS) by N(G)-nitro-L-arginine methyl ester (L-NAME) would alleviate the inhibition of mitochondrial oxygen uptake (Vo(2)) by nitric oxide and result in a speeding of phase II pulmonary Vo(2) kinetics at the onset of heavy-intensity exercise.	Oxygen	158-164	nitric oxide synthase 2	Homo sapiens	35-56
15080015-7	2004	The parallel increase in creatinine kinase concentration and A-a oxygen gradient indicates that IL-6 plays an important role in acute arterial occlusion and reperfusion injury.	Oxygen	65-71	interleukin 6	Homo sapiens	96-100
15072443-2	2004	In many tumors, VEGF plays a pivotal role for their vascularization and is necessary to supply the malignant tissue with oxygen and nutrients.	Oxygen	121-127	vascular endothelial growth factor A	Homo sapiens	16-20
14712484-1	2004	We examined how ionizing radiation (IR) delivered under either severe hypoxia (&lt; 0.1% O2) or normoxia affects the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins 1, 2 and 4 in U87 human glioblastoma cells.	Oxygen	89-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-174
15000391-7	2004	Superoxide dismutase (SOD) increased NO accumulation, suggesting that endogenous NO may modulate the level of H2O2 by interacting with O2- in the HR lesion.	Oxygen	112-114	superoxide dismutase 1	Homo sapiens	0-20
15000391-7	2004	Superoxide dismutase (SOD) increased NO accumulation, suggesting that endogenous NO may modulate the level of H2O2 by interacting with O2- in the HR lesion.	Oxygen	112-114	superoxide dismutase 1	Homo sapiens	22-25
15372127-5	2004	Neural fibers then release CGRP and other endogenous peptides to the coronary circulation reducing myocardial oxygen demand and enhancing vasodilation of collaterals to improve the myocardial blood flow of the most diseased regions of the heart.	Oxygen	110-116	calcitonin related polypeptide alpha	Homo sapiens	27-31
14691204-2	2004	The ARNT protein also forms heterodimers with other proteins such as HIF-1alpha and HIF-2alpha to alter gene expression in response to low oxygen conditions.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha a	Danio rerio	69-79
14961189-7	2004	Despite the compensatory increase in expression of iNOS and nNOS, nitric oxide bioavailability is reduced because of increased reaction rates with superoxide, yielding as by-products reactive nitrogen/oxygen species that induce protein nitration.	Oxygen	201-207	nitric oxide synthase 2	Homo sapiens	51-55
15095869-5	2004	In the absence of exogenous ligands (e.g. O2), the cytoglobin distal HisE7 residue is coordinated to the heme Fe atom, thus decreasing the ligand affinity.	Oxygen	42-44	cytoglobin	Homo sapiens	51-61
14660570-4	2004	Quantitative PCR demonstrates an up-regulation of cytoglobin mRNA levels in rat heart and liver under hypoxic conditions (22 and 44 h of 9% oxygen).	Oxygen	140-146	cytoglobin	Rattus norvegicus	50-60
14759647-9	2004	The O(2) utilized during enzymatic NO consumption is predicted to make the O(2) demands of activated macrophages much larger than those of unactivated ones (where iNOS is absent); this remains to be tested experimentally.	Oxygen	4-8	nitric oxide synthase 2	Homo sapiens	163-167
15031665-1	2004	Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
15031665-6	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Oxygen	183-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
15013423-1	2004	Hypoxia-inducible factor 1 (HIF-1) is a critical transcription factor for the adaptation to lowered oxygen environments.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15013423-1	2004	Hypoxia-inducible factor 1 (HIF-1) is a critical transcription factor for the adaptation to lowered oxygen environments.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
14741200-2	2004	Low oxygen tension increases the Epo levels by enhancing transcription, through the hypoxia-inducible factor (HIF)-1, a transcriptional modulator in oxygen-regulated gene expression.	Oxygen	4-10	erythropoietin	Homo sapiens	33-36
14970189-4	2004	Age-induced cell death is strongly delayed by overexpressing YAP1, a key transcriptional regulator in oxygen stress response.	Oxygen	102-108	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	61-65
15252555-1	2004	Dioxygen uptake by their dinuclear Co(II) complexes.	Oxygen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15252555-6	2004	Under aerobic conditions the binuclear Co(II) complexes of the ligands L1-L3 are able to bind molecular oxygen, with a bridging coordination of O2 between the two metals.	Oxygen	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15252555-6	2004	Under aerobic conditions the binuclear Co(II) complexes of the ligands L1-L3 are able to bind molecular oxygen, with a bridging coordination of O2 between the two metals.	Oxygen	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15059515-0	2004	[The overexpression and significance of MKP-1 in oxygen-deprived gastric cancer cell line SGC7901].	Oxygen	49-55	dual specificity phosphatase 1	Homo sapiens	40-45
15059515-1	2004	OBJECTIVE: To investigate the expression status of Mitogen-activated Protein Kinase Phosphatase-1 in oxygen-deprived gastric cancer cell line SGC7901 and its role in HIF-1 regulation.	Oxygen	101-107	dual specificity phosphatase 1	Homo sapiens	51-97
15059515-1	2004	OBJECTIVE: To investigate the expression status of Mitogen-activated Protein Kinase Phosphatase-1 in oxygen-deprived gastric cancer cell line SGC7901 and its role in HIF-1 regulation.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-171
14608012-3	2004	Using unrestrained, whole-body, flow-through plethysmography we found that, by postnatal day 4, the PACAP-null neonates had significantly reduced ventilation during baseline breathing, and blunted responses to both hypoxia (10% O2-90% N2) and hypercapnia (8% CO2-92% air).	Oxygen	228-230	adenylate cyclase activating polypeptide 1	Mus musculus	100-105
14627695-10	2004	Thus, oxygen deprivation-induced cell death in fibroblasts with deregulated expression of c-Myc is independent of p53 or HIF-1 status, but is dependent on the Bcl-2 family member Bax or Bak to initiate mitochondrial dependent cell death.	Oxygen	6-12	B cell leukemia/lymphoma 2	Mus musculus	159-164
14760391-0	2004	Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas.	Oxygen	59-65	involucrin	Homo sapiens	14-24
14760391-3	2004	Consistent with oxygen regulation, involucrin protein was found to increase with increasing hypoxia in confluent cultures of moderately differentiated human SCC9 cells.	Oxygen	16-22	involucrin	Homo sapiens	35-45
14760391-4	2004	Cells harvested at the point of confluence and exposed to graded concentrations of oxygen revealed a K(m) of approximately 15 mmHg for involucrin induction.	Oxygen	83-89	involucrin	Homo sapiens	135-145
14741200-2	2004	Low oxygen tension increases the Epo levels by enhancing transcription, through the hypoxia-inducible factor (HIF)-1, a transcriptional modulator in oxygen-regulated gene expression.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-116
14583436-2	2004	pVHL binding to HIF-1alpha is lost under low O2 tension, leading to transcription of several genes involved in the hypoxia response.	Oxygen	45-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
14527932-4	2004	However, BMC grown in low oxygen tension as found in other tissues (&lt;40 Torr, BMC(low)) were better phagocytes and APCs, similar to PM.	Oxygen	26-32	amyloid P component, serum	Mus musculus	118-122
14960044-10	2004	Although an increased expression of HSP72/73 was observed in each group 6 h after oxygen stress, only 100 micromol x L(-1) H2O2-treated cells remained at a high expression level after 24 h. CONCLUSION: It is likely that when cells encounter oxygen stress, an increased expression of HSP72/73 and subsequent repair of damaged proteins cause the retardation of cell cycle progression and prevent damaged cells from entering the S phase.	Oxygen	82-88	heat shock protein family A (Hsp70) member 1A	Homo sapiens	36-41
14564485-3	2004	Thus, As(III) in the adamsite molecule was oxidized by manganese peroxidase to As(V) which added dioxygen and released chloride.	Oxygen	97-105	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	79-84
14960044-10	2004	Although an increased expression of HSP72/73 was observed in each group 6 h after oxygen stress, only 100 micromol x L(-1) H2O2-treated cells remained at a high expression level after 24 h. CONCLUSION: It is likely that when cells encounter oxygen stress, an increased expression of HSP72/73 and subsequent repair of damaged proteins cause the retardation of cell cycle progression and prevent damaged cells from entering the S phase.	Oxygen	241-247	heat shock protein family A (Hsp70) member 1A	Homo sapiens	36-41
14965237-4	2004	Transcription factor NF-kappa B is reported to be the oxygen sensor in LPS induced endotoxemia.	Oxygen	54-60	nuclear factor kappa B subunit 1	Homo sapiens	21-31
14747339-0	2004	Oxidation of the Mn cluster induces structural changes of NO3- functionally bound to the Cl- site in the oxygen-evolving complex of photosystem II.	Oxygen	105-111	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
14712080-1	2004	HIF-1 is a transcription factor which acts as a master regulator coordinating oxygen homeostasis.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14712080-2	2004	An oxygen sensitive signal controlling HIF-1 is provided by enzymatic hydroxylation reactions which require molecular oxygen and modify specific prolyl and asparaginyl residues in the HIF a subunit.	Oxygen	3-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
14712080-2	2004	An oxygen sensitive signal controlling HIF-1 is provided by enzymatic hydroxylation reactions which require molecular oxygen and modify specific prolyl and asparaginyl residues in the HIF a subunit.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
14525767-1	2004	Hypoxia-inducible factor 1 (HIF-1) regulates many genes induced by low oxygen conditions.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
14525767-1	2004	Hypoxia-inducible factor 1 (HIF-1) regulates many genes induced by low oxygen conditions.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15013368-9	2004	VEGF and Bcl-2 immunoreactivity increased with prolonged exposure and increased extent of oxygen/metabolite deprivation.	Oxygen	90-96	vascular endothelial growth factor A	Homo sapiens	0-4
14751507-6	2004	The efficacy of TRAIL- and radiation-induced apoptosis under different oxygen conditions was quantified in vitro.	Oxygen	71-77	TNF superfamily member 10	Homo sapiens	16-21
14715687-5	2004	Examples include the neuronal bHLH-PAS carbon monoxide sensor NPAS2 that is implicated in the mammalian circadian clock, the acetobacterial oxygen sensor AxPDEA1 that directs cellulose production, and the rhizobial oxygen sensor FixL, which governs nitrogen fixation.	Oxygen	215-221	neuronal PAS domain protein 2	Homo sapiens	62-67
14980311-6	2004	RESULTS: : At 20% oxygen there was significantly reduced MMP-2 (P &lt; .05) and TIMP-1 (P &lt; .01) release and a trend for decreased MMP-9 release (P = .07) in explants from IUGR pregnancies compared with normal pregnancies; however, there were no differences at 3% oxygen.	Oxygen	18-24	TIMP metallopeptidase inhibitor 1	Homo sapiens	80-86
15013368-9	2004	VEGF and Bcl-2 immunoreactivity increased with prolonged exposure and increased extent of oxygen/metabolite deprivation.	Oxygen	90-96	BCL2 apoptosis regulator	Homo sapiens	9-14
15106882-8	2004	We suggest that a phosphate (or other activator) bound near the active site participates in AK catalysis by forming a transient pentavalent intermediate with a nonbridging oxygen of the beta-phosphate in ATP.	Oxygen	172-178	adenosine kinase	Homo sapiens	92-94
14767871-0	2004	Apolipoprotein E genotype and changes in serum lipids and maximal oxygen uptake with exercise training.	Oxygen	66-72	apolipoprotein E	Homo sapiens	0-16
15005300-6	2004	Mean bias for oxygen and nitrous oxide uptake was 0.003 l min(-1), for isoflurane 0.0001 l min(-1) and for carbon dioxide 0.001 l min(-1).	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	58-64
15032860-11	2004	Other stresses applied to the fruit, such as wounding, UV irradiation, water stress, low oxygen and exposure to the stress hormone ethylene decreased DHN mRNA levels, whereas abscisic acid had no effect at all.	Oxygen	89-95	dehydrin	Citrus sinensis	150-153
14738568-2	2004	Low oxygen tension within poorly-vascularized tumors is thought to be the prime stimulus causing the secretion of VEGF.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	114-118
15195597-10	2004	There were negative correlations between the concentration of ET-1 and the lowest oxygen desaturation in all the 60 OSAHS patients with and without hypertension (r = -0.230, P &lt; 0.05).	Oxygen	82-88	endothelin 1	Homo sapiens	62-66
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	CREB binding protein	Homo sapiens	63-83
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	CREB binding protein	Homo sapiens	85-88
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	120-126
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	CREB binding protein	Homo sapiens	128-131
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	hypoxia inducible factor 1 subunit alpha	Homo sapiens	241-251
15356719-4	2004	The structure of L(5) shows 3 methanol solvent molecules all of which form 2 or 3 hydrogen bonds with triazine nitrogen atoms, amide nitrogen or oxygen atoms, or pyridine nitrogen atoms.	Oxygen	145-151	ribosomal protein L5	Homo sapiens	17-21
12909591-0	2004	Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage.	Oxygen	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
15356722-2	2004	The oxidation of Ni(II) and Co(II) tetraglycine complexes in borate buffer aqueous solution, by dissolved oxygen, is strongly accelerated by sulfite.	Oxygen	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
14573596-4	2004	These findings suggest an enzymatic role for Pirin, most likely in biological redox reactions involving oxygen, and provide compelling evidence that Pirin requires the participation of the metal ion for its interaction with Bcl-3 to co-regulate the NF-kappaB transcription pathway and the interaction with NFI in DNA replication.	Oxygen	104-110	pirin	Homo sapiens	45-50
15448722-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master regulator of cellular and systemic oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15448722-1	2004	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master regulator of cellular and systemic oxygen homeostasis.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15448722-7	2004	Despite its name, HIF-1 is induced not only in response to reduced oxygen availability but also by other stimulants, such as nitric oxide, various growth factors, or direct inhibitors of prolyl and asparaginyl hydroxylases.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-143
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-155
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-143
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	148-155
14656932-6	2004	Intracellular radical oxygen species production prompted reduced protein expression of the transcriptional regulator nuclear factor 1 (NF-1).	Oxygen	22-28	neurofibromin 1	Homo sapiens	135-139
12909591-6	2004	An NF-kappa B mutation ablated baseline and O2- and LPS-stimulated reporter activity in both cell lines, whereas NF-IL6 mutations had little effect.	Oxygen	44-46	nuclear factor kappa B subunit 1	Homo sapiens	3-13
15646376-6	2004	Ozone/oxygen gaseous mixture reduced serum TNF-alpha levels in a dose-dependent manner.	Oxygen	6-12	tumor necrosis factor	Mus musculus	43-52
15205572-8	2004	Catalase, glutathione peroxidase, total and manganese superoxide dismutase activities as well as manganese superoxide dismutase (MnSOD) mRNA expression were elevated in both O2 groups after 7 days compared to the air groups (p &lt; 0.05) and MnSOD mRNA expression was elevated in the O2/dexamethasone group, but there were no differences between dexamethasone and saline groups in O2.	Oxygen	174-176	catalase	Rattus norvegicus	0-8
15696961-2	2004	On the other hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted attention because it is rapidly expressed when tissue oxygen tension is reduced, thus playing the role of a hypoxic sensor.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-70
15696961-2	2004	On the other hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted attention because it is rapidly expressed when tissue oxygen tension is reduced, thus playing the role of a hypoxic sensor.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
14726713-0	2004	HIF-1: an oxygen and metal responsive transcription factor.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14692041-13	2004	CONCLUSIONS: The current study indicates that the previously reported antiangiogenic activity of Genistein probably is mediated by the inhibition of HIF-1, an important regulator of VEGF gene homeostasis, particularly under low-oxygen conditions.	Oxygen	228-234	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-154
14726713-2	2004	The level of oxygen can be sensed by individual cells, which respond to reduced oxygenation (hypoxia) largely through activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-165
14726713-6	2004	Iron is central to the oxygen sensing mechanism, and sensitivity to other metals, namely cobalt and nickel, is a distinctive feature of the HIF system; in fact, this is often used as an initial way of implicating HIF-1 in a biological response.	Oxygen	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	213-218
14726713-2	2004	The level of oxygen can be sensed by individual cells, which respond to reduced oxygenation (hypoxia) largely through activation of hypoxia-inducible factor-1 (HIF-1).	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-158
15603511-1	2004	The p53 protein is an inducible transcription factor with multiple anti-proliferative roles in response to genotoxic damage; unprogrammed proliferative stimuli; and deprivation of oxygen, nutrients, or ribonucleotides.	Oxygen	180-186	tumor protein p53	Homo sapiens	4-7
12917010-7	2004	Our data are consistent with recent discoveries that the O2 sensing and regulation of EPO production is a complex process in which multiple factors, including cytokines and therapeutic agents, play a role by enhancing or inhibiting the response.	Oxygen	57-59	erythropoietin	Homo sapiens	86-89
15237209-7	2004	These results show that transcription of both Cpt1b and Cpt2 is triggered at the morula stage, concomitantly with known increasing profiles of oxygen uptake and fatty acids oxidation.	Oxygen	143-149	carnitine palmitoyltransferase 2	Mus musculus	56-60
14718443-13	2004	G-CSF in serum and IL-8 in BALF correlated negatively with PaO(2)/fraction of inspired oxygen (FIO(2)) ratio.	Oxygen	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
15078216-2	2004	A number of structural determinants for A(3)AR activation have recently been identified, including the N(6)-benzyl group, methanocarba substitution of ribose, 2-chloro and 2-fluoro substituents, various 2"- and 3"-substitutions and 4"-thio substitution of oxygen.	Oxygen	256-262	adenosine A3 receptor	Homo sapiens	40-46
14732290-5	2004	However, it has been suggested that H2O2 production, via Sod1 dismutation, is rate-limited by the availability of the substrate O2*-, and therefore age-related changes may occur as a result of other functions of Sod1.	Oxygen	38-40	superoxide dismutase 1, soluble	Mus musculus	57-61
15079902-3	2004	Both drugs also increased the oxygen affinity of hemoglobin in the P50 test in vitro.	Oxygen	30-36	nuclear factor kappa B subunit 1	Homo sapiens	67-70
14738229-9	2004	The reduction in oxygen saturation found in subjects with excessive erythrocytosis was small, yet consistent and potentially important, as it remained below the threshold known for the increase in erythropoietin stimulation.	Oxygen	17-23	erythropoietin	Homo sapiens	197-211
14992402-3	2004	Oxygen was measured as pO2 by the particlulate probes Gloxy and LiPc, which were surgically implanted at specific sites in tissues, and the soluble probe Trityl, which was administered intravenously.	Oxygen	0-6	lipase, hepatic	Mus musculus	64-68
14732290-5	2004	However, it has been suggested that H2O2 production, via Sod1 dismutation, is rate-limited by the availability of the substrate O2*-, and therefore age-related changes may occur as a result of other functions of Sod1.	Oxygen	38-40	superoxide dismutase 1, soluble	Mus musculus	212-216
14681851-0	2004	Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study.	Oxygen	75-81	apolipoprotein E	Homo sapiens	15-31
14694157-4	2004	Bradykinin, enalaprilat, and amlodipine significantly suppressed cortical oxygen consumption in 4-mo-old rats (bradykinin: -2.5 +/- 0.9% to -21 +/- 1.5%; enalaprilat: -0.7 +/- 0.5% to -26 +/- 1.2%; amlodipine: -1.3 +/- 0.9% to -18 +/- 1.2%; P &lt; 0.05).	Oxygen	74-80	kininogen 1	Homo sapiens	0-10
14694157-4	2004	Bradykinin, enalaprilat, and amlodipine significantly suppressed cortical oxygen consumption in 4-mo-old rats (bradykinin: -2.5 +/- 0.9% to -21 +/- 1.5%; enalaprilat: -0.7 +/- 0.5% to -26 +/- 1.2%; amlodipine: -1.3 +/- 0.9% to -18 +/- 1.2%; P &lt; 0.05).	Oxygen	74-80	kininogen 1	Homo sapiens	111-121
14694157-7	2004	Addition of the superoxide radical scavenger tempol restored the ability of bradykinin, enalaprilat, and amlodipine to suppress oxygen consumption in tissue from 23-mo-old animals to levels seen in younger animals, suggesting NO destruction by superoxide as the reason for decreased NO availability.	Oxygen	128-134	kininogen 1	Homo sapiens	76-86
15791851-4	2004	The level of HIF-1alpha in PC-3M significantly increased with the decrease of oxygen tension (P&lt;0.01).	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
15047111-0	2004	Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates.	Oxygen	114-120	NAD(P)H quinone dehydrogenase 1	Homo sapiens	8-45
15022889-5	2004	It has been demonstrated in clinical and experimental studies that exogenous VP treatment under this condition increases systemic vascular resistance, perfusion pressure, and oxygen supply to peripheral tissues, which makes it possible to decrease and to suspend vasopressors and also to increase survival.	Oxygen	175-181	arginine vasopressin	Homo sapiens	77-79
15190290-0	2004	Erythropoietin and erythropoiesis: polycythemias due to disruption of oxygen homeostasis.	Oxygen	70-76	erythropoietin	Homo sapiens	0-14
14702106-5	2004	However, exposure of adult Stat-3-deleted mice to 95% oxygen caused a more rapidly progressive lung injury associated with alveolar capillary leak and acute respiratory distress.	Oxygen	54-60	signal transducer and activator of transcription 3	Mus musculus	27-33
14702106-9	2004	Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury.	Oxygen	181-187	signal transducer and activator of transcription 3	Mus musculus	14-20
15193351-5	2004	Moreover EPO is capable of promoting angiogenesis in muscle cells, which provides an additional route to increase oxygen supply to active muscles.	Oxygen	114-120	erythropoietin	Homo sapiens	9-12
15047111-0	2004	Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates.	Oxygen	114-120	NAD(P)H quinone dehydrogenase 1	Homo sapiens	47-51
15627795-7	2004	Reduced oxygen tension (1% O2) led to the expected increase of EPO and EPO gene expression.	Oxygen	8-14	erythropoietin	Homo sapiens	63-66
16908971-6	2004	Moreover, the combination of hypocapnia (20 mm Hg CO2) and hypoxia (5%O2) induced caspase-3 activation and apoptosis in a synergistic manner.	Oxygen	51-53	caspase 3	Homo sapiens	82-91
15627795-7	2004	Reduced oxygen tension (1% O2) led to the expected increase of EPO and EPO gene expression.	Oxygen	8-14	erythropoietin	Homo sapiens	71-74
15627795-7	2004	Reduced oxygen tension (1% O2) led to the expected increase of EPO and EPO gene expression.	Oxygen	27-29	erythropoietin	Homo sapiens	63-66
15627795-7	2004	Reduced oxygen tension (1% O2) led to the expected increase of EPO and EPO gene expression.	Oxygen	27-29	erythropoietin	Homo sapiens	71-74
15627795-10	2004	This might point towards the hypothesis that in vivo renal cortical blood flow and consecutively the decrease of oxygen tension may lead to an increase of EPO secretion.	Oxygen	113-119	erythropoietin	Homo sapiens	155-158
15342936-3	2004	We report here that 7-day LCs of cord blood CD34+ cells at 3% O2 maintain SRC better than at 20% O2 and allow a similar amplification of CFCs (35- to 50-fold) without modifying the CD34+ cell proliferation.	Oxygen	62-64	CD34 molecule	Homo sapiens	44-48
15025431-8	2004	It could be hypothesized that the lower oxygen affinity to Hb in PV and ET patients partly explains the decreased EPO production.	Oxygen	40-46	erythropoietin	Homo sapiens	114-117
15379059-1	2004	Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2.	Oxygen	151-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
15379059-1	2004	Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2.	Oxygen	151-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
15342936-3	2004	We report here that 7-day LCs of cord blood CD34+ cells at 3% O2 maintain SRC better than at 20% O2 and allow a similar amplification of CFCs (35- to 50-fold) without modifying the CD34+ cell proliferation.	Oxygen	62-64	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	74-77
15298493-23	2004	Gut decontamination is not indicated following ingestion, due to the rapid decomposition of hydrogen peroxide by catalase to oxygen and water.	Oxygen	125-131	catalase	Homo sapiens	113-121
12966104-4	2003	These are reminiscent of the mechanism of cytochrome P-450, where a heme iron stabilizes the activated O2 species.	Oxygen	103-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58
14630097-1	2004	Dissolved oxygen uptake at a sediment/water interface (SOD) is controlled by mass transport and/or biochemical reactions in two adjacent boundary layers: the diffusive boundary layer delta(D) in the water and the penetration depth delta in the sediment.	Oxygen	10-16	superoxide dismutase 1	Homo sapiens	55-58
14657382-4	2003	Vessel loss is associated with oxygen-induced suppression of vascular endothelial growth factor (VEGF) and with pericyte (vascular smooth muscle cell) dropout.	Oxygen	31-37	vascular endothelial growth factor A	Homo sapiens	61-95
14657382-4	2003	Vessel loss is associated with oxygen-induced suppression of vascular endothelial growth factor (VEGF) and with pericyte (vascular smooth muscle cell) dropout.	Oxygen	31-37	vascular endothelial growth factor A	Homo sapiens	97-101
14657382-6	2003	We show that transforming growth factor beta1 (TGF-beta1)-expressing pericytes are specifically found on vessels resistant to oxygen-induced loss.	Oxygen	126-132	transforming growth factor beta 1	Homo sapiens	13-45
14657382-6	2003	We show that transforming growth factor beta1 (TGF-beta1)-expressing pericytes are specifically found on vessels resistant to oxygen-induced loss.	Oxygen	126-132	transforming growth factor beta 1	Homo sapiens	47-56
14657382-7	2003	TGF-beta1 potently induces VEGF receptor 1 (VEGFR-1) expression in endothelial cells and thereby prevents oxygen-induced vessel loss in vivo.	Oxygen	106-112	transforming growth factor beta 1	Homo sapiens	0-9
14657382-7	2003	TGF-beta1 potently induces VEGF receptor 1 (VEGFR-1) expression in endothelial cells and thereby prevents oxygen-induced vessel loss in vivo.	Oxygen	106-112	fms related receptor tyrosine kinase 1	Homo sapiens	27-42
14657382-7	2003	TGF-beta1 potently induces VEGF receptor 1 (VEGFR-1) expression in endothelial cells and thereby prevents oxygen-induced vessel loss in vivo.	Oxygen	106-112	fms related receptor tyrosine kinase 1	Homo sapiens	44-51
14657382-9	2003	TGF-beta1 induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen.	Oxygen	147-153	transforming growth factor beta 1	Homo sapiens	0-9
14657382-9	2003	TGF-beta1 induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen.	Oxygen	147-153	fms related receptor tyrosine kinase 1	Homo sapiens	23-30
14680803-1	2003	Transcription factor HIF-1 is a key determinant of oxygen-dependent gene regulation.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-26
14680803-8	2003	Moreover, this approach was found to suppress the shift from from S-phase to G1-phase observed in A549 cells in response to hypoxia, supporting a role of HIF-1alpha in oxygen-dependent cell cycle regulation.	Oxygen	168-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
14692760-1	2003	Heme oxygenase (HO) catalyzes the O2 and NADPH/cytochrome P450 reductase-dependent conversion of heme to biliverdin, free iron ion, and CO through a process in which the heme participates as both dioxygen-activating prosthetic group and substrate.	Oxygen	196-204	cytochrome p450 oxidoreductase	Homo sapiens	41-72
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Oxygen	43-49	cytoglobin	Homo sapiens	16-26
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Oxygen	109-115	cytoglobin	Homo sapiens	16-26
14695184-2	2003	It is composed of HIF-1alpha and HIF-1beta subunits and its activity depends on the amount of HIF-1alpha, which is tightly controlled by cellular oxygen tension.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
12966104-9	2003	In the context of the open and fully solvent-accessible active site for the homologous peptidylglycine-alpha-hydroxylating monooxygenase and by analogy to cytochrome P-450, the accumulation of a reduced and activated oxygen species in DbetaM before C-H cleavage would be expected to give some uncoupling of oxygen and substrate consumption.	Oxygen	127-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	155-171
12966104-9	2003	In the context of the open and fully solvent-accessible active site for the homologous peptidylglycine-alpha-hydroxylating monooxygenase and by analogy to cytochrome P-450, the accumulation of a reduced and activated oxygen species in DbetaM before C-H cleavage would be expected to give some uncoupling of oxygen and substrate consumption.	Oxygen	217-223	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	155-171
14625013-2	2003	In vitro studies have shown that mSOD1-induced, reactive oxygen species-mediated apoptosis of motor neurons depends on the presence of copper and the relative absence of zinc.	Oxygen	57-63	superoxide dismutase 1, soluble	Mus musculus	33-38
14671307-0	2003	Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-86
14671307-1	2003	Cells exposed to low oxygen concentrations respond by initiating defense mechanisms, including the stabilization of hypoxia-inducible factor (HIF) 1alpha, a transcription factor that upregulates genes such as those involved in glycolysis and angiogenesis.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-153
14604848-2	2003	Reactive oxygen and nitrogen species modulate ion channel function by a number of mechanisms including 1) transcriptional regulation of gene expression, 2) posttranslational modifications of channel proteins, i.e. nitrosylation, nitration, and oxidation of key amino acid residues, 3) by altering the gain in other signaling pathways that may in turn lead to changes in channel activity or channel gene expression, and 4) by modulating trafficking or turnover of channel proteins, as typified by oxygen radical activation of NF-kappa B, with subsequent changes in proteasomal degradation of channel degradation.	Oxygen	9-15	nuclear factor kappa B subunit 1	Homo sapiens	525-535
14656912-6	2003	Myocardial oxygen consumption (MVO2) of LV tissue was measured in vitro in response to bradykinin with preincubation of angiotensin II for 30 minutes.	Oxygen	11-17	kininogen 1	Canis lupus familiaris	87-97
14678869-7	2003	However, this benefit of exercise training and increased physical activity is complicated by the fact that individuals with insulin resistance or type 2 diabetes have decreased maximal exercise capacity or maximal oxygen consumption and have slower oxygen uptake kinetics at the beginning of exercise.	Oxygen	249-255	insulin	Homo sapiens	124-131
14678869-7	2003	However, this benefit of exercise training and increased physical activity is complicated by the fact that individuals with insulin resistance or type 2 diabetes have decreased maximal exercise capacity or maximal oxygen consumption and have slower oxygen uptake kinetics at the beginning of exercise.	Oxygen	214-220	insulin	Homo sapiens	124-131
14643931-4	2003	Taking into account the ratio of currents mediated by these channel subtypes in CA1 hippocampal neurons, we concluded that both types of HVA Ca2+ channels are sensitive to hypoxia, however, L-type was about 3.5 times more sensitive to oxygen reduction.	Oxygen	235-241	carbonic anhydrase 2	Rattus norvegicus	141-144
14633555-9	2003	Systemic and mesenteric oxygen delivery and consumption decreased and oxygen extraction increased in the VASO group.	Oxygen	24-30	vasopressin	Sus scrofa	105-109
14633555-9	2003	Systemic and mesenteric oxygen delivery and consumption decreased and oxygen extraction increased in the VASO group.	Oxygen	70-76	vasopressin	Sus scrofa	105-109
14705689-6	2003	Active warming improved thermal comfort and significantly reduced oxygen consumption from 9.7 (4.4) ml x min(-1) x kg(-1) to 5.6 (1.9) ml x min(-1) x kg(-1) (p = 0.038).	Oxygen	66-72	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
14639446-13	2003	The significant correlation between maximal oxygen consumption and insulin sensitivity indicates that, as in the able-bodied population, peak aerobic capacity is a predictive value with regard to insulin sensitivity in SCI.	Oxygen	44-50	insulin	Homo sapiens	67-74
14627433-3	2003	HIF-1alpha, a component of the heterodimer HIF-1, is rapidly degraded at high oxygen concentrations, and thus HIF-1 is only active as a transcription factor under hypoxic conditions.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
14627433-3	2003	HIF-1alpha, a component of the heterodimer HIF-1, is rapidly degraded at high oxygen concentrations, and thus HIF-1 is only active as a transcription factor under hypoxic conditions.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14627433-3	2003	HIF-1alpha, a component of the heterodimer HIF-1, is rapidly degraded at high oxygen concentrations, and thus HIF-1 is only active as a transcription factor under hypoxic conditions.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
14627433-5	2003	Close to hypoxia, low NO concentrations destabilized HIF-1alpha by inhibiting mitochondrial respiration, thereby increasing the local oxygen concentration.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
14627433-6	2003	In contrast, high NO concentrations stabilized HIF-1alpha at both high and low oxygen concentrations by a non-mitochondrial pathway.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
14627433-7	2003	These data resolve reported discrepancies on the effect of NO on HIF-1alpha stability at low oxygen concentrations and suggest that inhibition of mitochondrial respiration by NO may affect oxygen sensing by HIF-1 in vivo.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
14644195-8	2003	Loss of function of OPA-1, analogous to deficiency of its yeast homologue, Mgm1p, is expected to lead to mitochondrial fission, loss of mitochondrial DNA, respiratory deficits and an increase in reactive oxygen species.	Oxygen	204-210	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	20-25
14654739-0	2003	Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone?	Oxygen	10-16	angiotensinogen	Homo sapiens	60-74
14986813-6	2003	Hepatocyte necrosis and regeneration and the generation of oxygen and nitrogen reactive species resulting from chronic HBV infection increase the likelihood of the AFB1-induced p53 249ser and other mutations and the subsequent clonal expansion of cells containing these mutations.	Oxygen	59-65	tumor protein p53	Homo sapiens	177-180
14605793-1	2003	The aim was to determine whether uptake of 5-hydroxytryptamine (5-HT) by the 5-HT transporter (SERT) modulates contractile responses to 5-HT in rat pulmonary arteries and whether this modulation is altered by exposure of rats to chronic hypoxia (10% oxygen; 8 h/day; 5 days).	Oxygen	250-256	solute carrier family 6 member 4	Rattus norvegicus	95-99
14683498-4	2003	HIF-1 consists of an oxygen regulated alpha subunit and a constitutively expressed beta subunit, which bind and translocate to the nucleus to activate transcription of a range of genes involved in increasing glycolysis, inhibition of apoptosis and promotion of angiogenesis and metastasis.	Oxygen	21-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14688680-12	2003	To optimize postoperative recovery of newborns, consideration should be given to the levels of oxygen used to avoid the potential development of insulin resistance and subsequent decrease in glucose entry.	Oxygen	95-101	insulin	Homo sapiens	145-152
14614038-2	2003	In this study, we investigated the effect of changing oxygen tension on the expression and functional activity of endothelin-1 (ET-1) receptors in the penis.	Oxygen	54-60	endothelin 1	Homo sapiens	114-126
14614038-2	2003	In this study, we investigated the effect of changing oxygen tension on the expression and functional activity of endothelin-1 (ET-1) receptors in the penis.	Oxygen	54-60	endothelin 1	Homo sapiens	128-132
14625481-0	2003	Effect of Ibuprofen on interleukin-1beta-induced abnormalities in hemodynamics and oxygen metabolism in rabbits.	Oxygen	83-89	interleukin-1 beta	Oryctolagus cuniculus	23-40
14625481-1	2003	We showed previously that the administration of interleukin (IL)-1beta induces circulatory shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	113-119	interleukin-1 beta	Oryctolagus cuniculus	48-70
14625481-1	2003	We showed previously that the administration of interleukin (IL)-1beta induces circulatory shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	138-144	interleukin-1 beta	Oryctolagus cuniculus	48-70
14639446-13	2003	The significant correlation between maximal oxygen consumption and insulin sensitivity indicates that, as in the able-bodied population, peak aerobic capacity is a predictive value with regard to insulin sensitivity in SCI.	Oxygen	44-50	insulin	Homo sapiens	196-203
14609517-3	2003	During the TT mean oxygen consumption was 3.79 +/- 0.5 L x min(-1) (83 +/- 5.5% of VO2max) and mean blood lactate was 8.4 +/- 2.4 mM.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	59-65
12968018-7	2003	Loss of Nrf1 and Nrf2 leads to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen species levels and cell death that is reversed by culturing under reduced oxygen tension or the addition of antioxidants.	Oxygen	117-123	nuclear respiratory factor 1	Mus musculus	8-12
12968018-7	2003	Loss of Nrf1 and Nrf2 leads to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen species levels and cell death that is reversed by culturing under reduced oxygen tension or the addition of antioxidants.	Oxygen	117-123	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
14575853-1	2003	: inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-47
14636416-6	2003	Treatment with interferon-alpha (IFN-alpha) in hypoxia enhanced the cytotoxic potential of the NK cells less than it enhanced the cytotoxicity at ambient oxygen conditions.	Oxygen	154-160	interferon alpha 1	Homo sapiens	33-42
14636416-7	2003	In summary, the oxygen tension profoundly affects both the cytoxic activity of NK cells and their activation by IFN-alpha.	Oxygen	16-22	interferon alpha 1	Homo sapiens	112-121
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	Oxygen	124-126	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-67
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	Oxygen	124-126	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	138-141
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	Oxygen	124-126	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	138-141
14640466-5	2003	RESULTS: There was a strong correlation between maximal oxygen uptake and insulin-stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.	Oxygen	56-62	insulin	Homo sapiens	74-81
14616239-7	2003	O degrades HIF-1alpha, an HIF-1 subunit, by activating ubiquitin-proteasome and thereby decreases the transcriptional activation of many oxygen-sensitive genes.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-21
14616239-7	2003	O degrades HIF-1alpha, an HIF-1 subunit, by activating ubiquitin-proteasome and thereby decreases the transcriptional activation of many oxygen-sensitive genes.	Oxygen	137-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-16
12876069-5	2003	IGF-1 treatment also protected the redox potential of mesangial cells maintained at high ambient glucose concentration, by inhibiting the generation of reactive oxygen intermediates and preserving mitochondrial transmembrane potential.	Oxygen	161-167	insulin like growth factor 1	Homo sapiens	0-5
14595184-13	2003	These results suggests that hyperbaric oxygen reduces the accumulation of leukocytes in the TRAM flap, but not enough to prevent adhesion of neutrophils on endothelial cells; ischemia-reperfusion injury increases the expression of CD18 and ICAM-1 and causes increased adhesion of leukocytes on the endothelium; hyperbaric oxygen does not alter the expression of CD18 but decreases the expression of ICAM-1; and the point of application for hyperbaric oxygen, whether applied before or after reperfusion, did not show any differences in outcome.	Oxygen	39-45	integrin subunit beta 2	Rattus norvegicus	231-235
14595184-13	2003	These results suggests that hyperbaric oxygen reduces the accumulation of leukocytes in the TRAM flap, but not enough to prevent adhesion of neutrophils on endothelial cells; ischemia-reperfusion injury increases the expression of CD18 and ICAM-1 and causes increased adhesion of leukocytes on the endothelium; hyperbaric oxygen does not alter the expression of CD18 but decreases the expression of ICAM-1; and the point of application for hyperbaric oxygen, whether applied before or after reperfusion, did not show any differences in outcome.	Oxygen	39-45	integrin subunit beta 2	Rattus norvegicus	362-366
14581231-1	2003	The kinetics of formation and transformation of oxygen complexes of two heme-thiolate proteins (the F393H mutant of cytochrome P450 BM3 and the oxygenase domain of endothelial nitric oxide synthase, eNOS) were studied under high pressure.	Oxygen	48-54	nitric oxide synthase 3	Homo sapiens	164-197
14581231-6	2003	Furthermore, in the presence of 4-amino-tetrahydrobiopterin (ABH(4)), an analog to the natural second electron donor tetrahydrobiopterin (BH(4)), biphasic pressure profiles of the oxygen-binding rates were observed, both in the first and the second reaction cycles, indicative of the formation of an additional reaction intermediate.	Oxygen	180-186	alkB homolog 4, lysine demethylase	Homo sapiens	61-67
14612518-8	2003	Oxygen consumption rate was measured in NIH1286/VEGF+ [VEGF-transfected cells (VEGF+ cells)] and NIH1286/Vec cells [cells transfected with vector alone (Vec cells)] using a standard Clark oxygen electrode.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	48-52
14612518-8	2003	Oxygen consumption rate was measured in NIH1286/VEGF+ [VEGF-transfected cells (VEGF+ cells)] and NIH1286/Vec cells [cells transfected with vector alone (Vec cells)] using a standard Clark oxygen electrode.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	55-59
14612518-8	2003	Oxygen consumption rate was measured in NIH1286/VEGF+ [VEGF-transfected cells (VEGF+ cells)] and NIH1286/Vec cells [cells transfected with vector alone (Vec cells)] using a standard Clark oxygen electrode.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	55-59
14624631-0	2003	Prolonged oxygen-carrying ability of hemoglobin vesicles by coencapsulation of catalase in vivo.	Oxygen	10-16	catalase	Homo sapiens	79-87
14624631-7	2003	We succeeded in prolonging the oxygen-carrying ability of the Hb vesicle in vivo by the coencapsulation of catalase.	Oxygen	31-37	catalase	Homo sapiens	107-115
14612518-16	2003	VEGF+ and Vec cells had equivalent oxygen consumption rates.	Oxygen	35-41	vascular endothelial growth factor A	Homo sapiens	0-4
14605073-7	2003	Although not consistently shown, severity of OSA (ie, apnea-hypopnea index) and plasma epinephrine were independent predictors of platelet activity, and average minimal oxygen saturation was an independent predictor of fibrinogen.	Oxygen	169-175	fibrinogen beta chain	Homo sapiens	219-229
14640466-5	2003	RESULTS: There was a strong correlation between maximal oxygen uptake and insulin-stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.	Oxygen	142-148	insulin	Homo sapiens	74-81
14640466-6	2003	CONCLUSION: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.	Oxygen	20-26	insulin	Homo sapiens	74-81
14617263-2	2003	This study was designed to compare the effect of oxygen administration on pulmonary haemodynamics and tissue oxygenation during exercise in COPD patients with different ACE genotypes.	Oxygen	49-55	angiotensin I converting enzyme	Homo sapiens	169-172
14617263-9	2003	These findings suggest that the ability of oxygen administration to improve tissue oxygenation during exercise is associated with the ACE genotypes in COPD patients.	Oxygen	43-49	angiotensin I converting enzyme	Homo sapiens	134-137
14569080-0	2003	HIF-1: an oxygen response system with special relevance to the kidney.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14599483-5	2003	Here, we characterize cell death and the expression of Bcl-2 homologous proteins in 7-day-old neonatal rat cerebral cortex after hypoxia (5% O(2) for 40 min) and/or hyperoxia (&gt;95% O(2) for 2 h after hypoxia).	Oxygen	141-145	BCL2, apoptosis regulator	Rattus norvegicus	55-60
14599483-5	2003	Here, we characterize cell death and the expression of Bcl-2 homologous proteins in 7-day-old neonatal rat cerebral cortex after hypoxia (5% O(2) for 40 min) and/or hyperoxia (&gt;95% O(2) for 2 h after hypoxia).	Oxygen	184-188	BCL2, apoptosis regulator	Rattus norvegicus	55-60
14561390-1	2003	Erythropoietin (EPO) was originally identified as a hormone produced by the adult kidney to facilitate optimum delivery of oxygen to tissue beds by adjustment of the circulating erythrocyte mass.	Oxygen	123-129	erythropoietin	Homo sapiens	0-14
14561390-1	2003	Erythropoietin (EPO) was originally identified as a hormone produced by the adult kidney to facilitate optimum delivery of oxygen to tissue beds by adjustment of the circulating erythrocyte mass.	Oxygen	123-129	erythropoietin	Homo sapiens	16-19
14508692-4	2003	Professional cyclists achieved a maximal oxygen consumption, i.e. VO(2max), of 5.4 (0.5) l x min(-1) [74.6 (2.5) ml x min(-1) x kg(-1), range: 67.8-82.4 ml x min(-1) x kg(-1)] and a maximum power ( W(max)) of 475 (30) W (range: 438-516 W).	Oxygen	41-47	CD59 molecule (CD59 blood group)	Homo sapiens	93-99
14523474-0	2003	Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-149
14626370-7	2003	Oxygen consumption was 16% greater when running after the graded exercise test (47.9 +/- 5.0 ml x kg(-1) x min(-1); mean+/-s) than when running before it (41.1 +/- 2.7 ml x kg(-1) x min(-1)) (P &lt; 0.05).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	107-113
14626370-7	2003	Oxygen consumption was 16% greater when running after the graded exercise test (47.9 +/- 5.0 ml x kg(-1) x min(-1); mean+/-s) than when running before it (41.1 +/- 2.7 ml x kg(-1) x min(-1)) (P &lt; 0.05).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	182-188
14615416-3	2003	We examined the expression of PRL in cultured GH4C1 pituitary adenoma cells after exposure to hypoxia (0.1% oxygen) for periods of 12 to 36 hours.	Oxygen	108-114	prolactin	Rattus norvegicus	30-33
14586884-4	2003	These parameters include the effect of changes in oxyhemoglobin dissociation curve (ODC; expressed by P(50)) on oxygen availability, under the different circumstances occurring during liver transplantation.	Oxygen	112-118	nuclear factor kappa B subunit 1	Homo sapiens	102-107
14586884-11	2003	The intraoperative changes in P(50) values, which represent a shift of the ODC to the left, may reflect a more accurate estimation of O(2) release to the tissues, than the hemoglobin, Pao(2) and Sao(2) alone.	Oxygen	134-138	nuclear factor kappa B subunit 1	Homo sapiens	30-35
14586884-12	2003	Besides conventional hemodynamic parameters, P(50), which includes the effect of alterations in ODC on oxygen availability, could be of value in monitoring the systemic oxygenation during liver transplantation.	Oxygen	103-109	nuclear factor kappa B subunit 1	Homo sapiens	45-50
18969169-2	2003	To construct the biosensor catalase was immobilized by using gelatin and glutaraldehyde on a Clark type dissolved oxygen (DO) probe covered with a teflon membrane which is sensitive for oxygen.	Oxygen	114-120	catalase	Homo sapiens	27-35
14648482-4	2003	Oxygen appears to be a key factor controlling the mechanism of placentation by regulating the transcription of several genes, such as VEGF (vascular endothelial growth factor), leptin, etc.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	134-138
14648482-4	2003	Oxygen appears to be a key factor controlling the mechanism of placentation by regulating the transcription of several genes, such as VEGF (vascular endothelial growth factor), leptin, etc.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	140-174
14551773-0	2003	Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment.	Oxygen	7-13	erythropoietin	Homo sapiens	110-124
14704014-3	2003	The maximum specific growth rate, mum, was determined simultaneously according to measurements of oxygen consumption (i.e., oxygen uptake rate, OUR) and volatile suspended solids (VSS) increase.	Oxygen	98-104	latexin	Homo sapiens	8-11
14704014-3	2003	The maximum specific growth rate, mum, was determined simultaneously according to measurements of oxygen consumption (i.e., oxygen uptake rate, OUR) and volatile suspended solids (VSS) increase.	Oxygen	124-130	latexin	Homo sapiens	8-11
12907675-5	2003	Successive injections of LPS and dexamethasone or N-acetyl-cysteine prevented the induction of UCP2 in all three tissues, suggesting that oxygen free radical generation plays a role in UCP2 regulation.	Oxygen	138-144	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	95-99
12907675-5	2003	Successive injections of LPS and dexamethasone or N-acetyl-cysteine prevented the induction of UCP2 in all three tissues, suggesting that oxygen free radical generation plays a role in UCP2 regulation.	Oxygen	138-144	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	185-189
14551773-1	2003	We tested the hypothesis that prolonged administration of moderate doses of recombinant human erythropoietin (r-HuEPO) accelerates the initial rate of rise in pulmonary O2 uptake (VO2) in response to submaximal exercise and increases the maximal rate of O2 uptake (VO(2,max)).	Oxygen	169-171	erythropoietin	Homo sapiens	94-108
14551773-1	2003	We tested the hypothesis that prolonged administration of moderate doses of recombinant human erythropoietin (r-HuEPO) accelerates the initial rate of rise in pulmonary O2 uptake (VO2) in response to submaximal exercise and increases the maximal rate of O2 uptake (VO(2,max)).	Oxygen	181-183	erythropoietin	Homo sapiens	94-108
18969169-2	2003	To construct the biosensor catalase was immobilized by using gelatin and glutaraldehyde on a Clark type dissolved oxygen (DO) probe covered with a teflon membrane which is sensitive for oxygen.	Oxygen	186-192	catalase	Homo sapiens	27-35
18969169-4	2003	In the first reaction catalase catalyzes the degradation of hydrogen peroxide and oxygen is produced and also a steady-state DO concentration occurs in a few minutes.	Oxygen	82-88	catalase	Homo sapiens	22-30
12900407-7	2003	Taken together, our results suggest that AMPK is a novel and critical component of HIF-1 regulation, implying its new roles in oxygen-regulated cellular phenomena.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-88
12888568-7	2003	Since 2-OG-dependent dioxygenases require iron and oxygen, in addition to 2-OG, for substrate hydroxylation, we hypothesized that this activity may be involved in the regulation of IRP2 stability.	Oxygen	23-29	iron responsive element binding protein 2	Homo sapiens	181-185
14516198-0	2003	Kinetic studies of oxygen reactivity in soybean lipoxygenase-1.	Oxygen	19-25	seed linoleate 13S-lipoxygenase-1	Glycine max	48-62
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Oxygen	188-194	iron responsive element binding protein 2	Homo sapiens	39-43
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Oxygen	188-194	iron responsive element binding protein 2	Homo sapiens	64-68
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Oxygen	188-194	iron responsive element binding protein 2	Homo sapiens	64-68
14516198-1	2003	The reactivity of O(2) with soybean lipoxygenase-1 (SLO) has been examined using a range of kinetic probes.	Oxygen	18-22	seed linoleate 13S-lipoxygenase-1	Glycine max	36-50
14586087-2	2003	The nuclear anisotropic displacement parameters have been analysed showing that the carbon-oxygen skeleton conforms to a rigid-body (TLS) description.	Oxygen	91-97	FUS RNA binding protein	Homo sapiens	133-136
12874281-5	2003	In fresh human monocytes exposed to hypoxia (1% O2), there was an increase in COX-2 protein compared with cells in normoxia, and this was attributable to increased transcription and mRNA stability.	Oxygen	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
12876287-8	2003	Insulin treatment fails to inactivate proline hydroxylation of HIF-1alpha, which triggers recruitment of the von Hippel-Lindau protein and oxygen-dependent degradation of HIF-1alpha.	Oxygen	139-145	insulin	Homo sapiens	0-7
12876287-8	2003	Insulin treatment fails to inactivate proline hydroxylation of HIF-1alpha, which triggers recruitment of the von Hippel-Lindau protein and oxygen-dependent degradation of HIF-1alpha.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
12876287-8	2003	Insulin treatment fails to inactivate proline hydroxylation of HIF-1alpha, which triggers recruitment of the von Hippel-Lindau protein and oxygen-dependent degradation of HIF-1alpha.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
12816744-10	2003	Regulation of NaPi and PiUS mRNA expression was observed only in fish grown under optimal aqueous oxygen concentrations.	Oxygen	98-104	inositol hexakisphosphate kinase 2	Oncorhynchus mykiss	23-27
12730073-2	2003	Previous studies have determined that both interleukin (IL)-6 and IL-11 are protective in oxygen toxicity.	Oxygen	90-96	interleukin 6	Homo sapiens	43-61
12730074-6	2003	After hyperoxic exposure, L-selectin did not differ between the exposure groups but soluble L-selectin tended to increase in neonates after 7 d of O2 exposure Finally, CD18 was significantly higher after hyperoxic exposure of the adult (P = 0.008), but did not change with oxygen exposure in the neonate.	Oxygen	147-149	integrin subunit beta 2	Rattus norvegicus	168-172
12730074-6	2003	After hyperoxic exposure, L-selectin did not differ between the exposure groups but soluble L-selectin tended to increase in neonates after 7 d of O2 exposure Finally, CD18 was significantly higher after hyperoxic exposure of the adult (P = 0.008), but did not change with oxygen exposure in the neonate.	Oxygen	273-279	integrin subunit beta 2	Rattus norvegicus	168-172
14559797-2	2003	Tumor oxygenation is influenced by many interactions, including oxygen delivery (angiogenesis, permeability, and HgB) and consumption (metabolic and growth rates).	Oxygen	6-12	cytoglobin	Homo sapiens	113-116
14672330-5	2003	RESULTS: Simple regression analysis demonstrated a significant negative correlation between the concentrations of IL-8 and oxygen in FF (r = 0.50, P &lt; 0.0001).	Oxygen	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
14669980-7	2003	Sometimes the oxygen concentration also is of prime importance, since under normoxic conditions nitrosative stress activates HIF-1-dependent transcription, while under hypoxic conditions nitrosative stress leads to inhibition of HIF-1-dependent transcription.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-130
14669980-7	2003	Sometimes the oxygen concentration also is of prime importance, since under normoxic conditions nitrosative stress activates HIF-1-dependent transcription, while under hypoxic conditions nitrosative stress leads to inhibition of HIF-1-dependent transcription.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	229-234
14604332-6	2003	In an O2-free environment, DMS was converted primarily to CS2, methane (CH4), acetylene (C2H2), ethylene (C2H4), and hydrogen (H2), with traces of hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and dimethyl disulfide.	Oxygen	6-8	chorionic somatomammotropin hormone 2	Homo sapiens	58-61
14582920-6	2003	Ten DAN+ exhibited a mean lowest oxygen saturation &lt; 90% during REM sleep.	Oxygen	33-39	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
14526383-3	2003	HIF-1 is an essential component in changing the transcriptional repertoire of tissues as oxygen levels drop, and could prove to be a very important target for drug development, as treatments evolve for diseases, such as cancer, heart disease and stroke, in which hypoxia is a central aspect.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14604332-7	2003	In an O2-containing environment, the species detected were SO2, CS2, carbonyl sulfide, carbon dioxide (CO2), CH4, C2H4, C2H2, H2, formaldehyde, and methanol.	Oxygen	6-8	chorionic somatomammotropin hormone 2	Homo sapiens	64-67
12865501-0	2003	Sequence variation in hypoxia-inducible factor 1alpha (HIF1A): association with maximal oxygen consumption.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-53
12865501-0	2003	Sequence variation in hypoxia-inducible factor 1alpha (HIF1A): association with maximal oxygen consumption.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-60
12865501-2	2003	Genes regulated by HIF1 are involved in the processes of angiogenesis, erythropoiesis, and metabolism, making HIF1A a candidate gene in establishing maximal oxygen consumption (VO2 max) before and after aerobic exercise training.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-23
12865501-2	2003	Genes regulated by HIF1 are involved in the processes of angiogenesis, erythropoiesis, and metabolism, making HIF1A a candidate gene in establishing maximal oxygen consumption (VO2 max) before and after aerobic exercise training.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-115
14526226-2	2003	Treatment with IGF-I, IGF-II, or IGFBP-LI (2 microg/mL) significantly (P &lt; 0.05) reduced CA1 damage in organotypic hippocampal cultures resulting from 35 minutes of oxygen and glucose deprivation by 71%, 60%, and 40%, respectively.	Oxygen	168-174	insulin like growth factor 1	Homo sapiens	15-20
12928580-1	2003	The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
12928580-1	2003	The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
12928580-2	2003	As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amounts of HIF-1alpha under normoxic conditions.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
12967721-6	2003	Colocalisation of CNTF with CNTFRalpha, suggestive of ligand-receptor binding, was detected on outer segments, and in both normal retinas and retinas stressed by light or oxygen.	Oxygen	171-177	ciliary neurotrophic factor	Rattus norvegicus	18-22
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	Oxygen	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12968065-13	2003	The present study shows that exposure to low oxygen tension is capable of inducing programmed cell death and activating iNOS.	Oxygen	45-51	nitric oxide synthase 2	Rattus norvegicus	120-124
13678928-0	2003	Insulin ameliorates exercise ventilatory efficiency and oxygen uptake in patients with heart failure-type 2 diabetes comorbidity.	Oxygen	56-62	insulin	Homo sapiens	0-7
12939152-14	2003	This means not only that the HPPD.Fe(II).NTBC complex does not oxidize but also that the dissociation rate constant for NTBC is essentially zero because any HPPD.Fe(II) that formed would readily oxidize in the presence of dioxygen.	Oxygen	222-230	HPPD	Homo sapiens	29-33
12736139-4	2003	We found that BREC exposed to 40% oxygen (hyperoxia) for 48 h underwent apoptosis associated with activation of caspase-3 and cleavage of the caspase substrate poly(ADP-ribose) polymerase.	Oxygen	34-40	caspase 3	Homo sapiens	112-121
14521712-0	2003	A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-105
14521712-0	2003	A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation.	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
14521712-2	2003	Under normoxic conditions, the alpha subunit of HIF is rapidly degraded in a manner dependent on hydroxylation of two conserved proline residues at positions 402 and 564 in HIF-1alpha in the oxygen-dependent degradation (ODD) domain.	Oxygen	191-197	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-183
12750169-3	2003	Under low oxygen tensions Hb was previously found to modify apolipoprotein B100 with covalent binding of Hb fragments and formation of electronegative LDL particles (LDL-).	Oxygen	10-16	apolipoprotein B	Homo sapiens	60-79
12871028-3	2003	NO, a highly reactive radical, is produced from L-arginine and oxygen by the enzyme NO synthase (NOS).	Oxygen	63-69	nitric oxide synthase 2	Homo sapiens	84-95
12958195-4	2003	Epo protein production and promoter activity were induced in Hep3B cells with 1% O2.	Oxygen	81-83	erythropoietin	Homo sapiens	0-3
14964434-3	2003	An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under normoxic conditions but active in hypoxia, where it enhances Epo gene transcription resulting in elevated hemoglobin levels and O2 capacity of the blood.	Oxygen	3-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
14964434-3	2003	An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under normoxic conditions but active in hypoxia, where it enhances Epo gene transcription resulting in elevated hemoglobin levels and O2 capacity of the blood.	Oxygen	3-5	erythropoietin	Homo sapiens	178-181
14964434-4	2003	The stimulation of Epo production at lowered arterial O2 tension can be maladaptive, if erythrocytosis develops such as seen in high altitude habitants.	Oxygen	54-56	erythropoietin	Homo sapiens	19-22
14694976-6	2003	Preterm neonates positive for IL-1beta in their initial sample were on prolonged assisted ventilation (38 vs. 16 days, p = 0.013) and oxygen supplementation (62 vs. 40.5 days, p = 0.0462) and required prolonged hospitalization (69 vs. 46 days, p = 0.0165).	Oxygen	134-140	interleukin 1 beta	Homo sapiens	30-38
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	229-235	interleukin 6	Homo sapiens	0-13
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	229-235	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	268-274	interleukin 6	Homo sapiens	0-13
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	268-274	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
13129679-5	2003	Both constitutive and TNFalpha-induced apoptosis and cell loss were highest at low (&lt;10 mm Hg) and high ( approximately 140 mm Hg) oxygen tensions.	Oxygen	134-140	tumor necrosis factor	Homo sapiens	22-30
15038216-7	2003	Statistically significant were the differences between the arterial oxygen tension (PaO2) at Hb1 and Hb2 (p = 0.0001), as well as between the arterial oxygen saturation (SaO2) at the Hb1 and Hb2 values (p = 0.0001).	Oxygen	68-74	histocompatibility minor HB-1	Homo sapiens	93-96
12972882-5	2003	This combination of simultaneous increase in speed and grade yielded a linear work rate and its oxygen uptake response (R2 = 0.96 +/- 0.03) with a slope of 11.4 +/- 2.4 ml x min(-1) x W(-1)-slightly, but significantly, higher than on the cycle (9.6 +/- 2.0 ml x min(-1) x W(-1)).	Oxygen	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	174-180
12972882-5	2003	This combination of simultaneous increase in speed and grade yielded a linear work rate and its oxygen uptake response (R2 = 0.96 +/- 0.03) with a slope of 11.4 +/- 2.4 ml x min(-1) x W(-1)-slightly, but significantly, higher than on the cycle (9.6 +/- 2.0 ml x min(-1) x W(-1)).	Oxygen	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	262-268
12742081-4	2003	In this study the cellular localisation of the glutamate transporters GLAST and GLT-1 in organotypic hippocampal slice cultures was studied by immunofluorescence confocal microscopy, under normal culture conditions, and after a simulated ischemic insult, achieved by oxygen and glucose deprivation (OGD).	Oxygen	267-273	solute carrier family 1 member 3	Homo sapiens	70-75
12742081-4	2003	In this study the cellular localisation of the glutamate transporters GLAST and GLT-1 in organotypic hippocampal slice cultures was studied by immunofluorescence confocal microscopy, under normal culture conditions, and after a simulated ischemic insult, achieved by oxygen and glucose deprivation (OGD).	Oxygen	267-273	solute carrier family 1 member 2	Homo sapiens	80-85
12958623-5	2003	Active oxygen species sustained the increased MMP-9 activity for at least 24 h. In the post-hypoxic period 20 micro mol/L H(2)O(2) caused a 6-fold increase in the specific activity of MMP-9 over the normoxic cells and a comparable effect was exerted by thrombin (50 nmol/L) and leukocyte elastase (10 nmol/L).	Oxygen	7-13	coagulation factor II, thrombin	Homo sapiens	253-261
12761217-2	2003	Activation of the PI3K/AKT pathway has been shown to increase protein expression of the alpha subunit of the hypoxia-inducible factor (HIF) 1, a key regulator of oxygen homeostasis.	Oxygen	162-168	AKT serine/threonine kinase 1	Homo sapiens	23-26
14569522-10	2003	Arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (PAP) (r = 0.749, p &lt; 0.001), and arterial oxygen partial pressure (PaO2) (r = 0.79, p &lt; 0.001).	Oxygen	135-141	endothelin 1	Homo sapiens	9-13
12912907-0	2003	HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.	Oxygen	36-42	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-24
12912907-0	2003	HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
12912907-6	2003	We therefore conclude that, in vivo, PHDs have distinct assigned functions, PHD2 being the critical oxygen sensor setting the low steady-state levels of HIF-1alpha in normoxia.	Oxygen	100-106	egl-9 family hypoxia inducible factor 1	Homo sapiens	76-80
12912907-6	2003	We therefore conclude that, in vivo, PHDs have distinct assigned functions, PHD2 being the critical oxygen sensor setting the low steady-state levels of HIF-1alpha in normoxia.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
12912907-7	2003	Interestingly, PHD2 is upregulated by hypoxia, providing an HIF-1-dependent auto-regulatory mechanism driven by the oxygen tension.	Oxygen	116-122	egl-9 family hypoxia inducible factor 1	Homo sapiens	15-19
12912907-7	2003	Interestingly, PHD2 is upregulated by hypoxia, providing an HIF-1-dependent auto-regulatory mechanism driven by the oxygen tension.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-65
12782633-8	2003	LIF transgenic mice with a null mutation in IL-6 were more sensitive to the toxic effects of 100% O2 than LIF-transgenic animals with a wild-type IL-6 locus.	Oxygen	98-100	interleukin 6	Mus musculus	44-48
12914934-1	2003	Hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcriptional complex that plays pivotal role in the regulation of cellular utilization of oxygen as well as glucose and is an essential regulator of angiogenesis in solid tumor and ischemic disorders.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12914934-1	2003	Hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcriptional complex that plays pivotal role in the regulation of cellular utilization of oxygen as well as glucose and is an essential regulator of angiogenesis in solid tumor and ischemic disorders.	Oxygen	147-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12777372-6	2003	These data demonstrate a new mode of regulation of the mTOR pathway and position this pathway as a powerful point of control by O2 of cellular metabolism and energetics.	Oxygen	128-130	mechanistic target of rapamycin kinase	Homo sapiens	55-59
12934715-4	2003	Sod2-/- cultures showed accelerated cell death in serum-free conditions when grown in ambient oxygen.	Oxygen	94-100	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
12859980-2	2003	TXAS is a non-classic cytochrome P450 in that it does not require molecular oxygen or an external electron donor for catalysis.	Oxygen	76-82	thromboxane A synthase 1	Homo sapiens	0-4
12890175-18	2003	These results indicate that coadministered native SOD and catalase protect against gastric mucosal lesions in rats with WIR stress and suggest that this protective effect of coadministered native SOD and catalase could be due to their activity to scavenge XO-derived active oxygen species that are increased in the blood.	Oxygen	274-280	catalase	Rattus norvegicus	58-66
13678535-2	2003	Hypoxia inducible factor-1 (HIF-1) serves as a molecular bridge between the sensation and utilization of oxygen, and thus functions as a key player in oxygen homeostasis.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
13678535-2	2003	Hypoxia inducible factor-1 (HIF-1) serves as a molecular bridge between the sensation and utilization of oxygen, and thus functions as a key player in oxygen homeostasis.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
13678535-2	2003	Hypoxia inducible factor-1 (HIF-1) serves as a molecular bridge between the sensation and utilization of oxygen, and thus functions as a key player in oxygen homeostasis.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
13678535-2	2003	Hypoxia inducible factor-1 (HIF-1) serves as a molecular bridge between the sensation and utilization of oxygen, and thus functions as a key player in oxygen homeostasis.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
13678535-3	2003	HIF-1 is a heterodimeric transcription factor and is composed of two subunits, the oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
13678535-3	2003	HIF-1 is a heterodimeric transcription factor and is composed of two subunits, the oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
13678535-4	2003	HIF-1 regulates the expression of a broad range of genes that facilitate acclimation to low oxygen conditions by changes in protein levels in circulation, metabolism, and proliferation.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
13678535-7	2003	In this review, our first aim is to summarize the current knowledge of oxygen-dependent HIF-1 activation mechanisms based on its structure.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-93
12890175-18	2003	These results indicate that coadministered native SOD and catalase protect against gastric mucosal lesions in rats with WIR stress and suggest that this protective effect of coadministered native SOD and catalase could be due to their activity to scavenge XO-derived active oxygen species that are increased in the blood.	Oxygen	274-280	catalase	Rattus norvegicus	204-212
12895463-1	2003	The present study was designed to investigate the relative contributions of arterial P(O(2)), local cerebral blood flow, and oxygen delivery to the adenosine A(1) receptor-mediated depression of evoked synaptic transmission recorded in the rat hippocampus.	Oxygen	125-131	adenosine A1 receptor	Rattus norvegicus	148-171
12895463-7	2003	The adenosine A(1) receptor-mediated depression of the fEPSP was more strongly correlated with changes in HBF and oxygen delivery than with arterial P(O(2)).	Oxygen	114-120	adenosine A1 receptor	Rattus norvegicus	4-27
12858170-4	2003	In cultured cortical neurons, UCP-2 reduced cell death and inhibited caspase-3 activation induced by oxygen and glucose deprivation.	Oxygen	101-107	caspase 3	Homo sapiens	69-78
14629089-2	2003	Superoxide dismutase (SOD) is an antioxidant enzyme, which scavenges O2-.	Oxygen	69-71	superoxide dismutase 1	Homo sapiens	0-20
14629089-2	2003	Superoxide dismutase (SOD) is an antioxidant enzyme, which scavenges O2-.	Oxygen	69-71	superoxide dismutase 1	Homo sapiens	22-25
14629089-3	2003	We tested the hypothesis that a single intravenous dose of recombinant human Cu,Zn SOD (rhSOD) could influence microcirculation and biochemical markers of asphyxia in piglets reoxygenated with 21% or 100% O2 after combined cerebral hypoxemia-ischemia-hypercapnia.	Oxygen	205-207	superoxide dismutase 1	Homo sapiens	83-86
12914723-6	2003	IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally.	Oxygen	56-62	interleukin 6	Rattus norvegicus	0-4
12924491-0	2003	Effects of oxygen administration on the circulating vascular endothelial growth factor (VEGF) levels in patients with obstructive sleep apnea syndrome.	Oxygen	11-17	vascular endothelial growth factor A	Homo sapiens	52-86
12924491-0	2003	Effects of oxygen administration on the circulating vascular endothelial growth factor (VEGF) levels in patients with obstructive sleep apnea syndrome.	Oxygen	11-17	vascular endothelial growth factor A	Homo sapiens	88-92
12924491-8	2003	VEGF levels decreased from 515 +/- 31 (pg/ml) to 178 +/- 16 (pg/m) (p&lt;0.01) in OSAS patients whose nocturnal hypoxemia was found to be improved by administration of 2 l/min of oxygen during the night.	Oxygen	179-185	vascular endothelial growth factor A	Homo sapiens	0-4
12888312-5	2003	Heart rate, blood pressure, neural and humoral vasoactive factors such as plasma norepinephrine levels and renin activity, and probably also contractility are increased in the morning hours, indicating that increase in myocardial oxygen demand contribute importantly to the increased prevalence of ischemia in the morning.	Oxygen	230-236	renin	Homo sapiens	107-112
12869701-2	2003	One mechanism for RNA cleavage involves internal phosphoester transfer, wherein the 2"-oxygen atom carries out an SN2-like nucleophilic attack on the adjacent phosphorus center (transesterification).	Oxygen	87-93	solute carrier family 38 member 5	Homo sapiens	114-117
12913161-0	2003	A bypass of sucrose synthase leads to low internal oxygen and impaired metabolic performance in growing potato tubers.	Oxygen	51-57	sucrose synthase	Solanum tuberosum	12-28
12962153-9	2003	These data indicate that the transcriptional regulatory circuits involved in the control of MCAD gene expression under hypoxic conditions are modulated by upstream factors that are sensitive to the levels of oxygen.	Oxygen	208-214	acyl-CoA dehydrogenase medium chain	Homo sapiens	92-96
14655345-3	2003	The inhibition of SOD activity by copper diethyldithiocarbamate or the accelerated generation of O2-.	Oxygen	97-99	superoxide dismutase 1	Homo sapiens	18-21
12888880-0	2003	Enhanced TNF alpha and oxidative stress in patients with heart failure: effect of TNF alpha on platelet O2- production.	Oxygen	104-106	tumor necrosis factor	Homo sapiens	82-91
12868935-0	2003	Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system.	Oxygen	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	Oxygen	223-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12663441-3	2003	We here describe that Ang II highly stimulates endogenous and extracellular O2- production in these cells, consistent with the translocation to the cell membrane of the cytosolic components of NADPH oxidase, p47phox, and p67phox.	Oxygen	76-78	angiotensinogen	Homo sapiens	22-28
12880943-4	2003	The formation of superoxide anion via electron transfer to O2 was monitored by optical spectroscopy, using SOD-inhibitable cytochrome c reduction assay.	Oxygen	59-61	cytochrome c, somatic	Homo sapiens	123-135
12697770-5	2003	Expression was repressed by Mig1, which mediates responses to glucose, and Rox1, which mediates responses to oxygen.	Oxygen	109-115	Rox1p	Saccharomyces cerevisiae S288C	75-79
12663441-4	2003	The Ang II-dependent O2- production was suppressed by specific inhibitors of AT1 receptors, of the p38MAPK and ERK1/2 pathways, and of flavin oxidases.	Oxygen	21-23	angiotensinogen	Homo sapiens	4-10
12663441-4	2003	The Ang II-dependent O2- production was suppressed by specific inhibitors of AT1 receptors, of the p38MAPK and ERK1/2 pathways, and of flavin oxidases.	Oxygen	21-23	mitogen-activated protein kinase 3	Homo sapiens	111-117
12829158-5	2003	After 1 h, 6 h, and 18 h of in vitro hypoxia, a constant increase in HIF-1alpha protein levels with decreasing oxygen concentrations between 20% and &lt;0.02% was observed by both Western blot and flow cytometry, correlating with the pattern of pimonidazole labeling after in vitro hypoxia.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
12626334-6	2003	CGRP and RAMP1 ASODNs raised PPA in normoxic rats briefly exposed to 10% O2 above MMODN and saline controls.	Oxygen	73-75	receptor activity modifying protein 1	Rattus norvegicus	9-14
12833291-5	2003	Together with four methoxy groups anchored onto the primary face, the two P(III) centres of L 1 form a circularly arranged P(2)O(4) 12-electron donor set able to complex an Ag(+) ion in a dynamic way, each of the four oxygen atoms coordinating successively to the silver ion.	Oxygen	218-224	L1 cell adhesion molecule	Homo sapiens	92-95
12826846-8	2003	Compared with S. aureus, with E. coli antibody to TNF decreased alveolar-to-arterial oxygen gradients (P = 0.04) and increased serum interleukin-6 concentrations (P = 0.003).	Oxygen	85-91	tumor necrosis factor	Rattus norvegicus	50-53
12759799-3	2003	The proposed derivatization procedure protects Co(II) from oxidation by dissolved oxygen and enables rapid determination of all three metal species within a single run.	Oxygen	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
12914908-7	2003	The embedded catalase in PAM films showed the electrocatalytic activity toward dioxygen and hydrogen peroxide.	Oxygen	79-87	catalase	Homo sapiens	13-21
12678921-10	2003	Finally, we show that ectopic expression PGC1 beta leads to increased mitochondrial number and basal oxygen consumption.	Oxygen	101-107	PPARG coactivator 1 beta	Homo sapiens	41-50
12738801-6	2003	Wt1 expression was enhanced in the osteosarcoma line U-2OS and in Reh lymphoblast cells that were grown either at 1% O2 or in the presence of CoCl2 and desferrioxamine, respectively.	Oxygen	117-119	WT1 transcription factor	Homo sapiens	0-3
12943226-1	2003	Oxygen depravation in mammals leads to the transcriptional induction of a host of target genes to metabolically adapt to this deficiency, including erythropoietin and vascular endothelial growth factor.	Oxygen	0-6	erythropoietin	Homo sapiens	148-162
12943226-1	2003	Oxygen depravation in mammals leads to the transcriptional induction of a host of target genes to metabolically adapt to this deficiency, including erythropoietin and vascular endothelial growth factor.	Oxygen	0-6	vascular endothelial growth factor A	Homo sapiens	167-201
12823559-8	2003	The apparent Km values for oxygen differed significantly (NoxA-1, 0.06 mm; NoxB-1, 2.9 mm).	Oxygen	27-33	NADPH oxidase activator 1	Homo sapiens	58-64
14509702-3	2003	A 90% degradation of a 150-microM EDTA solution with continuous O2-bubbling was shown for the 20-kHz system in approximately 3 h (kpseudo-first order = 1.22 x 10(-2) min-1) and less than 1 h for the 354-kHz system (kpseudo-first order = 5.42 x 10(-2) min-1).	Oxygen	64-66	CD59 molecule (CD59 blood group)	Homo sapiens	166-171
12892369-6	2003	A fully automated gas testing rig was constructed to enable oxygen levels to be varied under computer control.	Oxygen	60-66	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	30-33
12929751-0	2003	Induction of tumor necrosis factor-alpha by UVB: a role for reactive oxygen intermediates and eicosanoids.	Oxygen	69-75	tumor necrosis factor	Homo sapiens	13-40
12810837-5	2003	Substrate for SOD was provided by reduction of oxygen during the autoxidation of riboflavin in the presence of UV light.	Oxygen	47-53	superoxide dismutase 1	Homo sapiens	14-17
12849846-2	2003	The present study examined the impact that specific Bzrp ligands have on oxygen homeostasis in the early mouse embryo.	Oxygen	73-79	translocator protein	Mus musculus	52-56
12849846-9	2003	These functional relationships suggest that Bzrp-dependent signals regulate the Nrf1 --&gt; Tfam1 --&gt; mtDNA --&gt; 16S rRNA pathway in response to oxygen levels.	Oxygen	150-156	translocator protein	Mus musculus	44-48
12849846-9	2003	These functional relationships suggest that Bzrp-dependent signals regulate the Nrf1 --&gt; Tfam1 --&gt; mtDNA --&gt; 16S rRNA pathway in response to oxygen levels.	Oxygen	150-156	nuclear respiratory factor 1	Mus musculus	80-84
14509702-3	2003	A 90% degradation of a 150-microM EDTA solution with continuous O2-bubbling was shown for the 20-kHz system in approximately 3 h (kpseudo-first order = 1.22 x 10(-2) min-1) and less than 1 h for the 354-kHz system (kpseudo-first order = 5.42 x 10(-2) min-1).	Oxygen	64-66	CD59 molecule (CD59 blood group)	Homo sapiens	251-256
12804584-0	2003	The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity.	Oxygen	97-103	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	23-28
12686560-11	2003	Molecular oxygen was needed for HCO3-/H2O2-dependent aggregation of hSOD1WT, implicating a role for a Trp-32-dependent peroxidative reaction in the covalent aggregation of hSOD1WT.	Oxygen	10-16	superoxide dismutase 1	Homo sapiens	68-73
12686560-11	2003	Molecular oxygen was needed for HCO3-/H2O2-dependent aggregation of hSOD1WT, implicating a role for a Trp-32-dependent peroxidative reaction in the covalent aggregation of hSOD1WT.	Oxygen	10-16	superoxide dismutase 1	Homo sapiens	68-75
12804584-7	2003	In contrast, transferring the S5-S6 segment of Kv1.2 into Kv2.1 produced an O(2)-sensitive K(+) current.	Oxygen	76-80	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	47-52
12804584-7	2003	In contrast, transferring the S5-S6 segment of Kv1.2 into Kv2.1 produced an O(2)-sensitive K(+) current.	Oxygen	76-80	potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog	Xenopus laevis	58-63
12804584-3	2003	Recombinant Kv1.2 currents expressed in Xenopus oocytes are inhibited by a decrease in O(2) availability.	Oxygen	87-91	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	12-17
12804584-5	2003	To elucidate the protein segment responsible for the O(2)-sensitivity of Kv1.2 channels, we analyzed the response to anoxia of Kv1.2/Kv2.1 chimeric channels.	Oxygen	53-57	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	73-78
12817295-6	2003	These results suggest that oxygen radical signals and mitochondrial K(ATP) channels are involved in the cardioprotection induced by TNF-alpha.	Oxygen	27-33	tumor necrosis factor	Homo sapiens	132-141
12804584-5	2003	To elucidate the protein segment responsible for the O(2)-sensitivity of Kv1.2 channels, we analyzed the response to anoxia of Kv1.2/Kv2.1 chimeric channels.	Oxygen	53-57	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	127-132
12804584-5	2003	To elucidate the protein segment responsible for the O(2)-sensitivity of Kv1.2 channels, we analyzed the response to anoxia of Kv1.2/Kv2.1 chimeric channels.	Oxygen	53-57	potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog	Xenopus laevis	133-138
12841268-1	2003	RuIV-CoIII (1:1.5) binary oxide, prepared by co-precipitation, is a highly efficient solid catalyst for the oxidation of primary alcohols to aldehydes with O2 (76-95% selectivity at 54-100% conversion) in a liquid phase under atmospheric pressure.	Oxygen	156-158	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	5-10
12730222-6	2003	Using purified catalases from a variety of species, the ROS generating activity was found to be temperature- and O2-dependent, stimulated by inhibitors of the catalatic activity of catalase, including 3-aminotriazole and azide, and inhibited by cyanide.	Oxygen	113-115	catalase	Homo sapiens	15-23
12794154-6	2003	Furthermore, we show that HSV triggers NF-kappaB activation by a signaling pathway involving oxidative stress in mitochondria and intracellular calcium, because specific inhibition of mitochondria-derived reactive oxygen intermediates, as well as mitochondrial calcium channels, prevented NF-kappaB activation.	Oxygen	214-220	nuclear factor kappa B subunit 1	Homo sapiens	39-48
12836066-1	2003	OBJECTIVE: To investigate clinical relevance and prognostic value of brain tissue oxygen response (TOR: response of brain tissue pO(2) to changes in arterial pO(2)) in traumatic brain injury (TBI).	Oxygen	82-88	RAR related orphan receptor C	Homo sapiens	99-102
12836066-21	2003	CONCLUSIONS: Evaluation of TOR affords insight in (disturbances in) oxygen regulation after traumatic brain injury, is of prognostic value and may aid in identifying patients at (increased) risk for ischemia.	Oxygen	68-74	RAR related orphan receptor C	Homo sapiens	27-30
12792702-10	2003	In conclusion, our data question the idea of adverse side effects of insulin treatment on oxygen transport.	Oxygen	90-96	insulin	Homo sapiens	69-76
12560208-0	2003	Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathway.	Oxygen	21-27	tumor necrosis factor	Rattus norvegicus	43-52
12576335-1	2003	We have generated a transgenic mouse line that reaches a hematocrit concentration of 0.85 due to constitutive overexpression of human erythropoietin in an oxygen-independent manner.	Oxygen	155-161	erythropoietin	Homo sapiens	134-148
12697836-6	2003	Caki-1 cells were exposed to hypoxia (1% O2) and exhibited increased Cdc42, Rac1 and RhoA protein expression.	Oxygen	41-43	ras homolog family member A	Homo sapiens	85-89
12839275-7	2003	It is proposed that oxygen triggers closure of the ductus arteriosus by activating a specific, cytochrome P450-linked reaction, which in turn stimulates the synthesis of ET-1.	Oxygen	20-26	endothelin 1	Homo sapiens	170-174
12697183-7	2003	Using pure oxygen, an optimal flow rate was observed at 300 ml min(-1), above which reactivity remains essentially constant.	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	63-69
12757848-4	2003	Among the postulated oxidative activities are the following: (i) peroxidase action; (ii) superoxide reductase action; and, (iii) the enhancement of production of O2- by partial reversal of the normal SOD activity, which then leads to increased formation of ONOO(-).	Oxygen	162-165	superoxide dismutase 1	Homo sapiens	200-203
12875367-0	2003	Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.	Oxygen	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
12938735-6	2003	Mice with endowed defences against superoxide or with deficiency in the nNOS and iNOS are protected from MPTP toxicity suggesting that formation of reactive oxygen and nitrogen intermediates both intracellularly and extracellularly contributes to the demise of dopaminergic neurons.	Oxygen	157-163	nitric oxide synthase 2, inducible	Mus musculus	81-85
12756290-1	2003	The enzyme endothelial nitric oxide synthase (eNOS) catalyzes the conversion of arginine, oxygen and NADPH to NO and citrulline.	Oxygen	90-96	nitric oxide synthase 3	Homo sapiens	11-44
12808484-13	2003	Moreover, alpha1-adrenergic receptors are present in the myocardium, and beta1-agonists, like beta-adrenergic agonists, increase myocardial oxygen consumption.	Oxygen	140-146	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	73-78
12756290-1	2003	The enzyme endothelial nitric oxide synthase (eNOS) catalyzes the conversion of arginine, oxygen and NADPH to NO and citrulline.	Oxygen	90-96	nitric oxide synthase 3	Homo sapiens	46-50
12853896-5	2003	RESULTS: The results indicated that oxygen consumption (VO2) was significantly higher in the K4b2 compared to the Quark at 80m x min(-1), 0% grade (14.3+/-1.2 vs 13.6+/-1.2ml x kg(-1) x min(-1), respectively), (p&lt;0.01).	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
12853896-5	2003	RESULTS: The results indicated that oxygen consumption (VO2) was significantly higher in the K4b2 compared to the Quark at 80m x min(-1), 0% grade (14.3+/-1.2 vs 13.6+/-1.2ml x kg(-1) x min(-1), respectively), (p&lt;0.01).	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	186-192
12853896-6	2003	The fractional concentration of oxygen in expired air was also significantly lower in the K4b2 at 80 m x min(-1), 0% grade and 80 m x min(-1), 10% grade (p&lt;0.05).	Oxygen	32-38	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
12853896-6	2003	The fractional concentration of oxygen in expired air was also significantly lower in the K4b2 at 80 m x min(-1), 0% grade and 80 m x min(-1), 10% grade (p&lt;0.05).	Oxygen	32-38	CD59 molecule (CD59 blood group)	Homo sapiens	134-140
12711384-2	2003	We developed a method to measure SPX activity in mixed whole saliva using an oxygen electrode.	Oxygen	77-83	lactoperoxidase	Homo sapiens	33-36
12854486-2	2003	We examined the possibility of using the oxygen concentrator, capable of producing 7 l.min-1 of oxygen, for anesthetic circuit.	Oxygen	41-47	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
12854486-2	2003	We examined the possibility of using the oxygen concentrator, capable of producing 7 l.min-1 of oxygen, for anesthetic circuit.	Oxygen	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
12854486-3	2003	When the oxygen concentrator is connected with an ordinary anesthetic vaporizer, the gas flow from the vaporizer is 6 l.min-1 and its vaporization is the same as when it is used with a high gas pressure.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
12805625-7	2003	We show that PDC1 is the only gene induced under oxygen limitation among the PDC1 gene family and that a pdc1 null mutant is comprised in anoxia tolerance but not other environmental stresses.	Oxygen	49-55	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	13-17
12805625-7	2003	We show that PDC1 is the only gene induced under oxygen limitation among the PDC1 gene family and that a pdc1 null mutant is comprised in anoxia tolerance but not other environmental stresses.	Oxygen	49-55	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	77-81
12805625-7	2003	We show that PDC1 is the only gene induced under oxygen limitation among the PDC1 gene family and that a pdc1 null mutant is comprised in anoxia tolerance but not other environmental stresses.	Oxygen	49-55	Thiamine pyrophosphate dependent pyruvate decarboxylase family protein	Arabidopsis thaliana	105-109
12776195-3	2003	By contrast, isogenic p53-null cells exposed to hypoxic conditions exhibited a 6-10-fold higher level of apoptosis, suggesting that p53 acts as a survival factor under limiting oxygen concentrations.	Oxygen	177-183	tumor protein p53	Homo sapiens	22-25
12776195-3	2003	By contrast, isogenic p53-null cells exposed to hypoxic conditions exhibited a 6-10-fold higher level of apoptosis, suggesting that p53 acts as a survival factor under limiting oxygen concentrations.	Oxygen	177-183	tumor protein p53	Homo sapiens	132-135
12748750-5	2003	For the DIHEN a nebuliser gas flow rate of 0.3 L min(-1) and 50 mL min(-1) of oxygen added to the plasma auxiliary gas flow gave stable conditions and high analyte sensitivity.	Oxygen	78-84	CD59 molecule (CD59 blood group)	Homo sapiens	67-73
12894587-10	2003	Finally LMP-1 induces expression of Hypoxia-Inducible Factor-1 alpha (HIF-1 alpha), which mediates adaptation of cells to O2-depleted states.	Oxygen	122-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-68
12894587-10	2003	Finally LMP-1 induces expression of Hypoxia-Inducible Factor-1 alpha (HIF-1 alpha), which mediates adaptation of cells to O2-depleted states.	Oxygen	122-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-81
12711384-3	2003	According to our results, when 50% of the peroxidase activity in saliva was due to MPO, determined using a typical substrate for peroxidase guaiacol, almost all oxygen evolved was due to SPX.	Oxygen	161-167	myeloperoxidase	Homo sapiens	83-86
12711384-3	2003	According to our results, when 50% of the peroxidase activity in saliva was due to MPO, determined using a typical substrate for peroxidase guaiacol, almost all oxygen evolved was due to SPX.	Oxygen	161-167	lactoperoxidase	Homo sapiens	187-190
12711384-4	2003	We propose that measurement of H(2)O(2)-dependent oxygen evolution is a useful method for determining SPX activity in whole saliva.	Oxygen	50-56	lactoperoxidase	Homo sapiens	102-105
12717822-0	2003	Fine tuning the HIF-1 "global" O2 sensor for hypobaric hypoxia in Andean high-altitude natives.	Oxygen	31-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
12717822-1	2003	Included in the acute response of lowlanders exposed to reduced oxygen availability is an elevated red blood cell count due to increased erythropoietin (Epo) synthesis.	Oxygen	64-70	erythropoietin	Homo sapiens	137-151
12717822-1	2003	Included in the acute response of lowlanders exposed to reduced oxygen availability is an elevated red blood cell count due to increased erythropoietin (Epo) synthesis.	Oxygen	64-70	erythropoietin	Homo sapiens	153-156
12678687-1	2003	Hypoxia inducible factor-1 (HIF-1) is a master regulator under conditions of decreased oxygen availability.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12718557-8	2003	These structural properties of the heme pocket of Cgb are discussed with respect to its proposed in vivo oxygen storage function.	Oxygen	105-111	cytoglobin	Homo sapiens	50-53
12816056-6	2003	O2.- is also a physiological substrate of myeloperoxidase.	Oxygen	0-2	myeloperoxidase	Homo sapiens	42-57
12678687-1	2003	Hypoxia inducible factor-1 (HIF-1) is a master regulator under conditions of decreased oxygen availability.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12678687-3	2003	The HIF-1 transcriptional system senses decreased oxygen availability and transmits this signal into patho-physiological responses such as angiogenesis, erythropoiesis, vasomotor control, an altered energy metabolism, as well as cell survival decisions.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
12816056-8	2003	O2.- affects the chlorinating and peroxidase activities of myeloperoxidase.	Oxygen	0-2	myeloperoxidase	Homo sapiens	59-74
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	23-29	nuclear factor kappa B subunit 1	Homo sapiens	93-102
12665562-1	2003	The transcription factor HIF-1alpha plays a crucial role in modifying gene expression during low oxygen tension.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	23-29	nuclear factor kappa B subunit 1	Homo sapiens	139-148
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	23-29	nuclear factor kappa B subunit 1	Homo sapiens	139-148
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	208-214	nuclear factor kappa B subunit 1	Homo sapiens	93-102
12759145-6	2003	In agreement with this, in vitro trophoblast expression of PGF can be down-regulated by low oxygen tension.	Oxygen	92-98	placental growth factor	Homo sapiens	59-62
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	208-214	nuclear factor kappa B subunit 1	Homo sapiens	139-148
12672017-8	2003	Inhibition of reactive oxygen intermediates with PDTC completely abolishes basal activity of NF-kappaB and strongly inhibits activation of NF-kappaB by neurotrophins, indicating an important role of reactive oxygen intermediates in the pathway by which neurotrophins activate NF-kappaB.	Oxygen	208-214	nuclear factor kappa B subunit 1	Homo sapiens	139-148
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Oxygen	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
12795136-5	2003	In this case, anesthesia was induced with sevoflurane and gradually increased to 5% in oxygen 4 l.min-1 and maintained with sevoflurane 2-3% in 2 nitrous oxide l.min-1 and 2 l.min-1 oxygen.	Oxygen	182-188	CD59 molecule (CD59 blood group)	Homo sapiens	162-173
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Oxygen	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-124
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Oxygen	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	196-206
12806962-8	2003	Our finding on Bach1 seems to be the first report of heme and oxygen-mediated regulation of genes in vertebrates.	Oxygen	62-68	BTB domain and CNC homolog 1	Homo sapiens	15-20
12586829-5	2003	Addition of the 530-603 C-terminal oxygen-dependent degradation (ODD) domain of HIF-1alpha to the green fluorescent protein (GFP) destabilized the protein in an oxygen-dependent manner.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
12744928-8	2003	In separate experiments, first trimester villi cultured under 10 per cent oxygen contained higher concentrations of catalase mRNA than controls maintained under 2.5 per cent oxygen.	Oxygen	74-80	catalase	Homo sapiens	116-124
12586829-5	2003	Addition of the 530-603 C-terminal oxygen-dependent degradation (ODD) domain of HIF-1alpha to the green fluorescent protein (GFP) destabilized the protein in an oxygen-dependent manner.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
12588875-2	2003	The transactivation activity of HIF complexes requires the recruitment of p300/CREB-binding protein (CBP) by HIF-1 alpha and HIF-2 alpha that undergo oxygen-dependent degradation.	Oxygen	150-156	CREB binding protein	Homo sapiens	79-99
12588875-2	2003	The transactivation activity of HIF complexes requires the recruitment of p300/CREB-binding protein (CBP) by HIF-1 alpha and HIF-2 alpha that undergo oxygen-dependent degradation.	Oxygen	150-156	CREB binding protein	Homo sapiens	101-104
12588875-2	2003	The transactivation activity of HIF complexes requires the recruitment of p300/CREB-binding protein (CBP) by HIF-1 alpha and HIF-2 alpha that undergo oxygen-dependent degradation.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-120
12667076-11	2003	Comparison of the spectral and physicochemical properties of the N-hydroxyguanidine complexes of BH(4)-free iNOS(oxy) (type II") with those of the previously described corresponding complexes of microperoxidase (MP-8) suggests that, in both cases, N-hydroxyguanidines bind to iron(III) via their oxygen atom after deprotonation or weakening of the O-H bond.	Oxygen	296-302	nitric oxide synthase 2	Homo sapiens	108-112
12695303-11	2003	Ad5-Kv1.5 restored the O2-sensitive K+ current of PASMCs, normalized HPV, and reduced pulmonary vascular resistance.	Oxygen	23-25	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	4-9
12670503-2	2003	When oxygen tension is reduced, PHD-mediated hydroxylation cannot occur, HIF-1 alpha accumulates in the nucleus, resulting in HIF-mediated gene transcription.	Oxygen	5-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-84
12606472-4	2003	VEGF concentrations also declined (P &lt; 0.05) in control, CoCl2, and CoCl2 + LH groups in 0% O2, although CoCl2 modestly increased (75% above control; P &lt; 0.05) VEGF levels in 20% and 5% O2.	Oxygen	95-97	vascular endothelial growth factor A	Homo sapiens	0-4
12670191-2	2003	In arginine-fed control rats, urinary and/or serum levels of guanidino compounds, nitric oxide (NO), urea, protein, and glucose increased significantly, while the renal activities of the oxygen species-scavenging enzymes superoxide dismutase (SOD) and catalase decreased, compared with casein-fed rats.	Oxygen	187-193	catalase	Rattus norvegicus	252-260
12671019-1	2003	BACKGROUND: Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic (low-oxygen) conditions.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-44
12671019-1	2003	BACKGROUND: Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic (low-oxygen) conditions.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
12671019-1	2003	BACKGROUND: Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic (low-oxygen) conditions.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-51
12817626-3	2003	The aim of this study was to evaluate the effects of chronic exposure to low oxygen tension on the induction of inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) in rat heart.	Oxygen	77-83	nitric oxide synthase 2	Rattus norvegicus	112-143
12817626-3	2003	The aim of this study was to evaluate the effects of chronic exposure to low oxygen tension on the induction of inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) in rat heart.	Oxygen	77-83	nitric oxide synthase 2	Rattus norvegicus	145-149
12606472-4	2003	VEGF concentrations also declined (P &lt; 0.05) in control, CoCl2, and CoCl2 + LH groups in 0% O2, although CoCl2 modestly increased (75% above control; P &lt; 0.05) VEGF levels in 20% and 5% O2.	Oxygen	192-194	vascular endothelial growth factor A	Homo sapiens	0-4
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Oxygen	91-97	iron responsive element binding protein 2	Homo sapiens	17-21
12615973-0	2003	Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.	Oxygen	79-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-47
12615973-1	2003	Hypoxia-inducible factor1 (HIF-1) is an essential transcription factor for cellular adaptation to decreased oxygen availability.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-25
12615973-1	2003	Hypoxia-inducible factor1 (HIF-1) is an essential transcription factor for cellular adaptation to decreased oxygen availability.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-32
12615973-2	2003	In normoxia the oxygen-sensitive alpha-subunit of HIF-1 is hydroxylated on Pro564 and Pro402 and thus targeted for proteasomal degradation.	Oxygen	16-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	12-18	egl-9 family hypoxia inducible factor 1	Homo sapiens	68-72
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	96-102	egl-9 family hypoxia inducible factor 1	Homo sapiens	68-72
12729258-9	2003	In the case of HIF-1 induction, a cell is now equipped with the expression of a variety of genes that will allow the cell to survive the lack of oxygen and thus should enable a previously initiated cancer cell to progress into a full malignant state and metastasize.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-20
12684384-5	2003	Moreover, we show that the HOG1 gene plays a role in chlamydospore formation, another oxygen-related morphogenetic event, as demonstrated by the fact that hog1 cells were unable to generate these thick-walled structures in several media through a mechanism different from that of the EFG1 regulator.	Oxygen	86-92	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	27-31
12654479-1	2003	Reversal of the superoxide dismutase (SOD) reaction was measured in terms of the reduction of tetranitromethane (TNM) by O2-.	Oxygen	121-124	superoxide dismutase 1	Homo sapiens	16-36
12654479-1	2003	Reversal of the superoxide dismutase (SOD) reaction was measured in terms of the reduction of tetranitromethane (TNM) by O2-.	Oxygen	121-124	superoxide dismutase 1	Homo sapiens	38-41
12657504-9	2003	Reducing the oxygen tension led to a selective increase in fibronectin and collagen IV production.	Oxygen	13-19	fibronectin 1	Homo sapiens	59-70
12793050-10	2003	There was a significant increase in the capacity of the transport system expressed by the value of the maximum oxygen uptake (from 1545 +/- 312 to 1740 +/- 359 ml.min-1) and MET (from 5.3 +/- 1.3 to 6.0 +/- 1.4).	Oxygen	111-117	CD59 molecule (CD59 blood group)	Homo sapiens	163-168
12668302-7	2003	FINDINGS: By using the Hudson non-rebreathing mask with three valves, increasing the oxygen flow to 15 l min(-1), and fitting the mask tightly to the face the average expired oxygen fraction could be raised to 0.85.	Oxygen	175-181	CD59 molecule (CD59 blood group)	Homo sapiens	105-111
12626552-3	2003	The role of Cu/Zn superoxide dismutase (SOD-1), an important enzyme in cellular oxygen metabolism, was examined in activated peritoneal elicited macrophages (PEM) and in several inflammatory processes in vivo.	Oxygen	80-86	superoxide dismutase 1, soluble	Mus musculus	40-45
12605983-0	2003	Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-45
12605983-14	2003	The HIF-1alpha antisense treatment exerted an oxygen-independent, and additive but not synergistic effect to the cytotoxicity of cisplatin, etoposide, and vincristine.	Oxygen	46-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-14
12538644-3	2003	This process is dependent on the hydroxylation of conserved proline residues on the alpha subunits of HIF-1/2 in the presence of oxygen.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-109
12538644-5	2003	We demonstrate that the common oxygen-dependent degradation domain of hHIF-3 alpha 1-3 splice variants is targeted for ubiquitylation by the pVHL complex in vitro and in vivo.	Oxygen	31-37	hypoxia inducible factor 3 subunit alpha	Homo sapiens	70-86
12631267-6	2003	Despite favorable energy scores, tyrosine in a position trans to PAH residue His290 or TH residue His336 interferes with the access of the essential cofactor dioxygen to the catalytic center, thereby blocking the enzymatic reaction.	Oxygen	158-166	tyrosine hydroxylase	Homo sapiens	87-89
12511571-10	2003	Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells.	Oxygen	118-124	BTB domain and CNC homolog 1	Homo sapiens	11-16
18968967-3	2003	The development of two polyphenol oxidase (PPO) sensors, based on monitoring the enzymatic consumption of oxygen using an oxygen electrode, or reduction of enzymatically generated o-quinone at a screen-printed electrode (SPE), for the measurement of phenol in transformer oil is reported.	Oxygen	106-112	protoporphyrinogen oxidase	Homo sapiens	23-41
18968967-3	2003	The development of two polyphenol oxidase (PPO) sensors, based on monitoring the enzymatic consumption of oxygen using an oxygen electrode, or reduction of enzymatically generated o-quinone at a screen-printed electrode (SPE), for the measurement of phenol in transformer oil is reported.	Oxygen	106-112	protoporphyrinogen oxidase	Homo sapiens	43-46
18968967-3	2003	The development of two polyphenol oxidase (PPO) sensors, based on monitoring the enzymatic consumption of oxygen using an oxygen electrode, or reduction of enzymatically generated o-quinone at a screen-printed electrode (SPE), for the measurement of phenol in transformer oil is reported.	Oxygen	122-128	protoporphyrinogen oxidase	Homo sapiens	23-41
18968967-3	2003	The development of two polyphenol oxidase (PPO) sensors, based on monitoring the enzymatic consumption of oxygen using an oxygen electrode, or reduction of enzymatically generated o-quinone at a screen-printed electrode (SPE), for the measurement of phenol in transformer oil is reported.	Oxygen	122-128	protoporphyrinogen oxidase	Homo sapiens	43-46
12641237-4	2003	For small peptides, such as angiotensin I (Agt I) and [Gln11]-amyloid-beta-protein fragment 1-16 (A beta(1-16)), the optimum conditions for specific modification involve the use of Cu(II)/ascorbate/O2.	Oxygen	198-200	angiotensinogen	Homo sapiens	28-41
12641237-4	2003	For small peptides, such as angiotensin I (Agt I) and [Gln11]-amyloid-beta-protein fragment 1-16 (A beta(1-16)), the optimum conditions for specific modification involve the use of Cu(II)/ascorbate/O2.	Oxygen	198-200	angiotensinogen	Homo sapiens	43-48
12603312-4	2003	In addition to this oxygen-dependent response, increased HIFalpha protein levels and/or enhanced transcriptional activity during normoxic conditions can be stimulated by various receptor-mediated factors such as growth-factors and cytokines (insulin, insulin-like growth factor 1 or 2, endothelial growth factor, tumour necrosis factor alpha, angiotensin-2).	Oxygen	20-26	insulin like growth factor 1	Homo sapiens	251-284
12588957-7	2003	This observation has potential therapeutic implications because the DT-diaphorase metabolic pathway is influenced by many agents, including drugs, diet, and environmental cell factors such as pH and oxygen tension.	Oxygen	199-205	NAD(P)H quinone dehydrogenase 1	Homo sapiens	68-81
12590978-7	2003	Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation.	Oxygen	57-63	interleukin 6	Homo sapiens	14-18
12590978-7	2003	Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation.	Oxygen	65-70	interleukin 6	Homo sapiens	14-18
12590978-7	2003	Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation.	Oxygen	65-69	interleukin 6	Homo sapiens	14-18
12614847-5	2003	As an intracellular oxygen sensor, heme stimulated TSA2 transcription by activating Hap1p.	Oxygen	20-26	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	51-55
12621249-4	2003	Hematological and molecular studies revealed that the boy is homozygous for Hb Tak, an extended beta-globin variant with high oxygen affinity.	Oxygen	126-132	cyclin dependent kinase 9	Homo sapiens	79-82
12657718-5	2003	Treatment of MCF-7 human breast cancer and HT-29 human colon carcinoma cells with PX-12 and pleurotin prevented the hypoxia (1% oxygen)-induced increase in HIF-1alpha protein.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
24616606-6	2003	LT oxygen consumption was significantly improved in Test 2 versus Test 1 (P&lt;0.01) VT was also improved (P&lt;0.05).	Oxygen	3-9	serine protease 21	Homo sapiens	66-72
12480940-8	2003	Ferrous eNOS(ox), in the presence of l-arginine, is fully functional in forming the tetrahydrobiopterin radical upon mixing with oxygen as demonstrated by rapid-freeze EPR measurements.	Oxygen	129-135	nitric oxide synthase 3	Homo sapiens	8-12
12360391-7	2003	Moreover, the VEGF levels were negatively correlated with oxygen saturation (p = 0.03) and positively correlated with hemoglobin (p = 0.004) in CHD patients aged between 3 months and 10 years.	Oxygen	58-64	vascular endothelial growth factor A	Homo sapiens	14-18
12360391-8	2003	Although the physiologic elevation of VEGF in the neonatal period decreases rapidly if oxygen saturation is normal, VEGF elevations persist if systemic hypoxia is present.	Oxygen	87-93	vascular endothelial growth factor A	Homo sapiens	38-42
12685656-2	2003	PSI-dependent oxygen uptake activity was stable during the first 3 h of photoinhibitory illumination in the presence of added superoxide dismutase (SOD).	Oxygen	14-20	superoxide dismutase 1	Homo sapiens	126-146
12685656-2	2003	PSI-dependent oxygen uptake activity was stable during the first 3 h of photoinhibitory illumination in the presence of added superoxide dismutase (SOD).	Oxygen	14-20	superoxide dismutase 1	Homo sapiens	148-151
12685656-3	2003	Without added SOD, the oxygen uptake almost doubled during this period, presumably due to the denaturation of native membrane-bound SOD or its release from the PSI membranes.	Oxygen	23-29	superoxide dismutase 1	Homo sapiens	132-135
12371906-3	2003	Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta.	Oxygen	50-56	endothelin 1	Rattus norvegicus	164-176
12573279-1	2003	A catalytic amount of cytochrome c (cyto-c) added to the incubation medium of isolated mitochondria promotes the transfer of reducing equivalents from extramitochondrial nicotinamide adenine dinucleotide in its reduced state (NADH) to molecular oxygen inside the mitochondria, a process coupled to the generation of a membrane potential.	Oxygen	245-251	cytochrome c, somatic	Homo sapiens	22-34
12573279-1	2003	A catalytic amount of cytochrome c (cyto-c) added to the incubation medium of isolated mitochondria promotes the transfer of reducing equivalents from extramitochondrial nicotinamide adenine dinucleotide in its reduced state (NADH) to molecular oxygen inside the mitochondria, a process coupled to the generation of a membrane potential.	Oxygen	245-251	cytochrome c, somatic	Homo sapiens	36-42
12706763-8	2003	RESULTS: Under 10 cmH2O EPAP, the required oxygen flow is &lt; or = 30 l x min(-1).	Oxygen	43-49	troponin T2, cardiac type	Homo sapiens	18-22
12706763-8	2003	RESULTS: Under 10 cmH2O EPAP, the required oxygen flow is &lt; or = 30 l x min(-1).	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	75-81
18968912-2	2003	The Eu(fod)(3) interaction displayed the selective binding role of oxygen on macrocyclic, H(2)COCH(2), backbones with o- or m-dioxyphenyl groups referring the (1)H chemical shifts.	Oxygen	67-73	cochlin	Homo sapiens	94-98
12371906-3	2003	Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta.	Oxygen	50-56	angiotensinogen	Rattus norvegicus	178-192
12371906-3	2003	Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta.	Oxygen	50-56	interleukin 1 beta	Rattus norvegicus	197-214
12582222-2	2003	In the present study, we determined whether insulin resistance in obesity is associated with an impaired ability of exercise to stimulate muscle blood flow, oxygen delivery, or glucose uptake.	Oxygen	157-163	insulin	Homo sapiens	44-51
12558074-4	2003	HIF-1 controls cellular and systemic responses to oxygen availability and coordinates up-regulation of genes involved in many pathways concerned with tumour growth and metabolism including angiogenesis, glucose and energy metabolism, cellular proliferation, differentiation and viability, apoptosis, pH regulation and matrix metabolism.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12391094-5	2003	Arm-crank peak oxygen consumption (in ml x kg(-1) x min(-1)) increased by 16% (P &lt; 0.05) after training, and significant differences (P &lt; 0.05) were found in wall thickness (from 0.86 to 0.99 cm) but not in left ventricular internal dimension in diastole or systole.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	52-58
12522812-3	2003	We have recently found that the administration of a recombinant human serum albumin (rHSA)-based oxygen carrier involving synthetic tetraphenyporphinatoiron(II) derivative (FeP) (rHSA-FeP) does not induce such hypertensive action, because of its low permeability through the vascular endothelium.	Oxygen	97-103	albumin	Homo sapiens	70-83
12617740-0	2003	Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1alpha.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-156
12566247-0	2003	Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-61
12486718-2	2003	Leghemoglobin serves an additional role as an oxygen scavenger to prevent inhibition of nitrogen fixation.	Oxygen	46-52	leghemoglobin A	Glycine max	0-13
12486718-3	2003	For this purpose, the oxygen affinity of soybean leghemoglobin is 20-fold greater than myoglobin, resulting from an 8-fold faster association rate constant combined with a 3-fold slower dissociation rate constant.	Oxygen	22-28	leghemoglobin A	Glycine max	49-62
12486718-6	2003	Oxygen and carbon monoxide binding to a comprehensive set of leghemoglobin distal heme pocket mutant proteins in comparison to their myoglobin counterparts has revealed some of these mechanisms.	Oxygen	0-6	leghemoglobin A	Glycine max	61-74
12507560-2	2003	pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the degradation of hypoxia-inducible factor-1 (HIF) alpha-subunits, a process regulated by oxygen availability and blocked by disease causing pVHL mutations.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-138
12486718-8	2003	Furthermore, soybean leghemoglobin uses an unusual combination of HisE7 and TyrB10 to sustain a weak stabilizing interaction with bound oxygen.	Oxygen	136-142	leghemoglobin A	Glycine max	21-34
12486718-9	2003	Thus, the leghemoglobin distal heme pocket provides a much lower barrier to oxygen association than occurs in myoglobin and oxygen dissociation is regulated from the proximal heme pocket.	Oxygen	76-82	leghemoglobin A	Glycine max	10-23
12486718-9	2003	Thus, the leghemoglobin distal heme pocket provides a much lower barrier to oxygen association than occurs in myoglobin and oxygen dissociation is regulated from the proximal heme pocket.	Oxygen	124-130	leghemoglobin A	Glycine max	10-23
12524110-1	2003	Preliminary results for collisional broadening are reported for two lines P(8) and R(32) of the nu3-nu1 band of CS2 in mixture with O2 and air.	Oxygen	132-134	chorionic somatomammotropin hormone 2	Homo sapiens	112-115
12578128-9	2003	Tissue oxygen use as estimated by LACi increased transiently at the beginning of volume expansion with similar maximum values.	Oxygen	7-13	tissue factor pathway inhibitor	Oryctolagus cuniculus	34-38
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	Oxygen	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
12560087-1	2003	Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a master regulator to sense decreased oxygen partial pressure.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
12560087-1	2003	Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a master regulator to sense decreased oxygen partial pressure.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-45
12560087-2	2003	HIF-1 alpha stability regulation initiates a complex biological response that allows cells to act appropriately to meet patho-physiological situations of decreased oxygen availability.	Oxygen	164-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
12403774-2	2003	On the other hand, the activity of cytochrome c oxidase is unchanged for the first 8 h after staurosporine treatment, as determined by oxygen consumption measurements in intact cells.	Oxygen	135-141	cytochrome c, somatic	Homo sapiens	35-47
12515825-4	2003	Caspase-3 disrupts oxygen consumption induced by complex I and II substrates but not that induced by electron transfer to complex IV.	Oxygen	19-25	caspase 3	Homo sapiens	0-9
12563064-3	2003	The vascular endothelial growth factor (VEGF) gene is highly sensitive to changes in tissue partial oxygen tension, and changes in genomic and protein expression occur even after changes in oxygenation within the physiologic range.	Oxygen	100-106	vascular endothelial growth factor A	Homo sapiens	4-38
12563064-3	2003	The vascular endothelial growth factor (VEGF) gene is highly sensitive to changes in tissue partial oxygen tension, and changes in genomic and protein expression occur even after changes in oxygenation within the physiologic range.	Oxygen	100-106	vascular endothelial growth factor A	Homo sapiens	40-44
12480550-2	2003	HIF-1 plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumor.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14713113-5	2003	Respiration of isolated heart mitochondria follows hyperbolic oxygen kinetics with half-saturating oxygen pressure, p50, of 0.04 kPa (0.3 Torr; 0.4 microM) in ADP-stimulated state 3.	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	116-119
14713113-6	2003	Thus mitochondrial respiration proceeds at 90% of its hyperbolic maximum at the p50 of myoglobin, suggesting the possibility of a small but significant oxygen limitation even under normoxia in active muscle.	Oxygen	152-158	nuclear factor kappa B subunit 1	Homo sapiens	80-83
14713115-3	2003	While the feedback loop wherein tissue oxygen pressure determines the production of erythropoietin, which further drives the production of red blood cells in the bone marrow, explains how the hematocrit is generated, it does not speak to how the hematocrit is regulated.	Oxygen	39-45	erythropoietin	Homo sapiens	84-98
14713115-8	2003	Hence, it may be the kidneys ability to report a measure of ECF volume as a tissue oxygen signal and thus to regulate the hematocrit that establishes it as the logical site of erythropoietin production.	Oxygen	83-89	erythropoietin	Homo sapiens	176-190
14713115-10	2003	Renal vasculature and nephron segment heterogeneity in sodium reabsorption likely provides the anatomical construct to generate the marginal tissue oxygen pressure required to trigger the production of erythropoietin.	Oxygen	148-154	erythropoietin	Homo sapiens	202-216
14713116-2	2003	Increased erythropoietin plasma levels and the consequent augmented production of red blood cells is the best known systemic adaptation to reduced oxygen partial pressure (pO2).	Oxygen	147-153	erythropoietin	Homo sapiens	10-24
14713116-5	2003	HIF-1 is a heterodimer consisting of an oxygen sensitive--HIF-1--and an oxygen-independent subunit--HIF-1beta (also known as the aryl hydrocarbon receptor nuclear translocator--ARNT).	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14713116-5	2003	HIF-1 is a heterodimer consisting of an oxygen sensitive--HIF-1--and an oxygen-independent subunit--HIF-1beta (also known as the aryl hydrocarbon receptor nuclear translocator--ARNT).	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
14713116-7	2003	Recently, the critical involvement of HIF-1alpha post-translational modifications in the cellular oxygen sensing mechanism was discovered.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48
12495935-4	2003	Northern blot analysis showed that this decay: (i) was observed as a marked diminution of transcript levels after 24-48 h of exposure to low oxygen tension; (ii) is not mediated by the transcription factor, hypoxia inducible factor-1; and (iii) is partially dependent on a higher hnRNP A2/B1 messenger RNA turnover under hypoxic than normoxic conditions.	Oxygen	141-147	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	280-291
14570584-7	2003	During terminal branching, FGF expression is regulated by hypoxia, ensuring that tracheal structure matches cellular oxygen need.	Oxygen	117-123	branchless	Drosophila melanogaster	27-30
12496536-15	2003	In contrast, animals treated with IL-1alpha showed an increase in postburn mesenteric oxygen supply and consumption.	Oxygen	86-92	interleukin 1 alpha	Sus scrofa	34-43
12524266-3	2003	The model predicts that after activation of a neutrophil, an increase in the activity of the hexose monophosphate shunt and the delivery of myeloperoxidase into the phagosome results in oscillations in oxygen and NAD(P)H concentration.	Oxygen	202-208	myeloperoxidase	Homo sapiens	140-155
14569872-13	2003	CONCLUSION: Ceramide synthesis and sphingomyelin breakdown, caspase activation and reactive oxygen metabolites production are required for the TNF-alpha-induced apoptosis and necrosis which may be regulated dependently on cell cycle.	Oxygen	92-98	tumor necrosis factor	Homo sapiens	143-152
14635422-6	2003	Other key elements of cell response to hypoxia have been described recently--von Hippel-Lindau protein and prolyl hydroxylases, that allow degradation of alpha-subunit of HIF-1 during normal oxygen tension.	Oxygen	191-197	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-176
14569872-0	2003	[TNF-induced apoptosis and necrosis in myeloleukemia cells HL-60 is regulated by reactive oxygen metabolites depending on a cell cycle phase].	Oxygen	90-96	tumor necrosis factor	Homo sapiens	1-4
14580258-1	2003	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) is part of a transcriptional factor that regulates genes involved in metabolic and vascular adaptation of tumours to oxygen restriction.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-43
14580258-1	2003	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) is part of a transcriptional factor that regulates genes involved in metabolic and vascular adaptation of tumours to oxygen restriction.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
15369237-3	2003	On the other hand, attempts have been made to improve maximal oxygen uptake by artificial means: blood doping, administration of human recombinant erythropoietin and, probably, by the use of a new class of therapeutic agents: the oxygen carriers.	Oxygen	62-68	erythropoietin	Homo sapiens	147-161
14635422-7	2003	This can ensure low level of HIF-1 in cells under physiological oxygen tension thus the expression of target genes is maintained on basal level.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
12638238-2	2003	Under 20% oxygen, the percentage of embryos that developed to blastocysts and expanded blastocysts, and nuclear numbers were lower in Slc embryos than in Nrs embryos.	Oxygen	10-16	chemokine (C-C motif) ligand 21A (serine)	Mus musculus	134-137
12570801-5	2003	Finally, we will present recent advances into oxygen-sensing, in particular the HIF-hydroxylases that govern HIF-1alpha instability (PHD2) or inactivation (FIH-1).	Oxygen	46-52	egl-9 family hypoxia inducible factor 1	Homo sapiens	133-137
12483106-2	2003	Rac-GTP is a component of the membrane-assembled NADPH oxidase complex, and new evidence suggests that Rac-GTP interacts directly with the oxidase flavocytochrome, in addition to binding to the regulatory p67 subunit, to regulate electron transfer both independently and cooperatively from NADPH to molecular oxygen.	Oxygen	309-315	thymoma viral proto-oncogene 1	Mus musculus	0-3
12483106-2	2003	Rac-GTP is a component of the membrane-assembled NADPH oxidase complex, and new evidence suggests that Rac-GTP interacts directly with the oxidase flavocytochrome, in addition to binding to the regulatory p67 subunit, to regulate electron transfer both independently and cooperatively from NADPH to molecular oxygen.	Oxygen	309-315	thymoma viral proto-oncogene 1	Mus musculus	103-106
12483106-2	2003	Rac-GTP is a component of the membrane-assembled NADPH oxidase complex, and new evidence suggests that Rac-GTP interacts directly with the oxidase flavocytochrome, in addition to binding to the regulatory p67 subunit, to regulate electron transfer both independently and cooperatively from NADPH to molecular oxygen.	Oxygen	309-315	CD33 molecule	Homo sapiens	205-208
12496163-1	2003	Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen peroxide and molecular oxygen and has been shown to contribute to the virulence of many human-pathogenic bacteria through its ability to neutralize toxic levels of reactive oxygen species generated by the host.	Oxygen	111-117	superoxide dismutase 1	Homo sapiens	0-20
12524467-10	2003	Oxygen-dependent regulation of EPO gene expression is postulated to be controlled by a hypoxia-inducible transcription factor (HIF-1alpha).	Oxygen	0-6	erythropoietin	Homo sapiens	31-34
12524467-10	2003	Oxygen-dependent regulation of EPO gene expression is postulated to be controlled by a hypoxia-inducible transcription factor (HIF-1alpha).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
12496163-1	2003	Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen peroxide and molecular oxygen and has been shown to contribute to the virulence of many human-pathogenic bacteria through its ability to neutralize toxic levels of reactive oxygen species generated by the host.	Oxygen	111-117	superoxide dismutase 1	Homo sapiens	22-25
12447987-1	2003	Oxygen-dependent regulation of HIF-1 activity occurs at multiple levels in vivo.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-36
12585337-8	2003	The initial physical condition of these patients was lower than expected, and improved after treatment with an increase in maximum oxygen consumption from 2.0 +/- 1.2 to 2.33 +/- 0.68 l x min(-1) (p = 0.01).	Oxygen	131-137	CD59 molecule (CD59 blood group)	Homo sapiens	188-194
12585337-13	2003	Further studies investigating GH action on maximum oxygen consumption are required, once its basic mechanism of action has been determined, either in the heart or peripheral factors.	Oxygen	51-57	growth hormone 1	Homo sapiens	30-32
12508095-9	2003	Paradoxically, peak oxygen consumption (an indicator of fitness) was negatively correlated with adiponectin levels (r = -0.471, p = 0.013) and positively correlated with TNF-alpha (r = 0.560, p = 0.002).	Oxygen	20-26	adiponectin, C1Q and collagen domain containing	Homo sapiens	96-107
12953846-1	2003	The microbicidal activity of the myeloperoxidase (MPO)-hydrogen peroxide-halide system has been implicated as the most efficient, oxygen-dependent antimicrobial component of neutrophil host defense.	Oxygen	130-136	myeloperoxidase	Homo sapiens	33-48
12953846-1	2003	The microbicidal activity of the myeloperoxidase (MPO)-hydrogen peroxide-halide system has been implicated as the most efficient, oxygen-dependent antimicrobial component of neutrophil host defense.	Oxygen	130-136	myeloperoxidase	Homo sapiens	50-53
12499918-8	2003	In vitro, all pancreatic cancer cell lines increased VEGF production when exposed to low oxygen levels, by highly specific activation of HIF-1 DNA binding activity to the VEGF promoter.	Oxygen	89-95	vascular endothelial growth factor A	Homo sapiens	53-57
12499918-8	2003	In vitro, all pancreatic cancer cell lines increased VEGF production when exposed to low oxygen levels, by highly specific activation of HIF-1 DNA binding activity to the VEGF promoter.	Oxygen	89-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-142
12499918-8	2003	In vitro, all pancreatic cancer cell lines increased VEGF production when exposed to low oxygen levels, by highly specific activation of HIF-1 DNA binding activity to the VEGF promoter.	Oxygen	89-95	vascular endothelial growth factor A	Homo sapiens	171-175
12472784-2	2003	Angiotensin II (Ang II) acting on Type I receptors (AT1-R) causes renal oxidative stress and functional nitric oxide (NO) deficiency that could enhance O2 usage.	Oxygen	152-154	angiotensinogen	Rattus norvegicus	0-14
12472784-2	2003	Angiotensin II (Ang II) acting on Type I receptors (AT1-R) causes renal oxidative stress and functional nitric oxide (NO) deficiency that could enhance O2 usage.	Oxygen	152-154	angiotensinogen	Rattus norvegicus	16-22
12829875-8	2003	It is thought that nitric oxide synthase catalyses transport of electrons for reactions between molecular oxygen and L-arginine.	Oxygen	106-112	nitric oxide synthase 2	Homo sapiens	19-40
12508095-9	2003	Paradoxically, peak oxygen consumption (an indicator of fitness) was negatively correlated with adiponectin levels (r = -0.471, p = 0.013) and positively correlated with TNF-alpha (r = 0.560, p = 0.002).	Oxygen	20-26	tumor necrosis factor	Homo sapiens	170-179
12505746-0	2003	The potential value of the protein S-100B level as a criterion for hyperbaric oxygen treatment and prognostic marker in carbon monoxide poisoned patients.	Oxygen	78-84	S100 calcium binding protein B	Homo sapiens	27-41
15139279-7	2003	These results indicate that significant fractions of cellular ATP in iNOS-positive peritoneal macrophages are synthesized by the increased activity of glycolysis particularly under physiological low oxygen tensions where the mitochondrial respiration is strongly inhibited by endogenously generated NO by macrophages and neutrophils.	Oxygen	199-205	nitric oxide synthase 2	Rattus norvegicus	69-73
12448000-7	2002	Severe hypoxia (0.2% O2), but not moderate hypoxia (5% O2) raised VEGF mRNA expression and protein secretion in 7/9 and 5/9 cell lines, respectively.	Oxygen	21-23	vascular endothelial growth factor A	Homo sapiens	66-70
12505283-5	2002	For example, oxyradical overload diseases such as Wilson disease and hemochromatosis result in the generation of oxygen/nitrogen species that can cause mutations in the p53 tumor suppressor gene.	Oxygen	113-119	tumor protein p53	Homo sapiens	169-172
15969046-1	2003	Hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcription factor that plays an important role in oxygen homeostasis.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15969046-1	2003	Hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcription factor that plays an important role in oxygen homeostasis.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
15969046-2	2003	In response to low level of oxygen, subunit HIF-1alpha expression is upregulated and transactivates its target genes essential for energy metabolism, erythropoiesis and vascular development.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
12468103-8	2002	Using quantitative real-time RT-PCR, we further studied the expression of presenilin-2 mRNA under conditions of low oxygen supply and glucose starvation.	Oxygen	116-122	presenilin 2	Rattus norvegicus	74-86
12468103-9	2002	Glucose deprivation itself caused significant up-regulation of the presenilin-2 (to 160%) and with low oxygen increased presenilin-2 level to over 200% of the control.	Oxygen	103-109	presenilin 2	Rattus norvegicus	120-132
12414157-2	2002	We have shown by both in vitro and in vivo studies that activation of macrophages with interferon-gamma (IFN-gamma) is an important factor for control of infection with B. abortus in the mouse model and that the mechanism of anti-brucella activity largely involved reactive oxygen intermediates.	Oxygen	274-280	interferon gamma	Mus musculus	105-114
12480817-4	2002	In the present study, electron spin resonance spectroscopy is utilized to demonstrate that VEGF stimulates O2*- production, which is inhibited by the NAD(P)H oxidase inhibitor, diphenylene iodonium, as well as by overexpression of dominant-negative Rac1 (N17Rac1) and transfection of gp91(phox) antisense oligonucleotides in human umbilical vein endothelial cells (ECs).	Oxygen	107-109	vascular endothelial growth factor A	Homo sapiens	91-95
12379645-1	2002	Hypoxia-inducible factor-1 (HIF-1) regulates the transcription of many genes induced by low oxygen conditions.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12379645-1	2002	Hypoxia-inducible factor-1 (HIF-1) regulates the transcription of many genes induced by low oxygen conditions.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12370489-3	2002	Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf-1 mediated caspase-9 activation.	Oxygen	27-33	cytochrome c, somatic	Homo sapiens	76-88
12630074-3	2002	The effects mediated by growth hormone comprise an increase in muscle mass, a decrease in body fat, improved physical condition, oxygen consumption and overall quality of life, an improvement of the ratio of high-density lipoprotein to low-density lipoprotein, as well as an increase in bone density.	Oxygen	129-135	growth hormone 1	Homo sapiens	24-38
12388163-6	2002	Pretreatment with oxygen free radical scavengers, superoxide dismutase (50,000 U/kg) and catalase (90,000 U/kg), also attenuated these PGF(2 alpha)-induced alterations.	Oxygen	18-24	catalase	Rattus norvegicus	72-97
12370489-3	2002	Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf-1 mediated caspase-9 activation.	Oxygen	27-33	apoptotic peptidase activating factor 1	Homo sapiens	93-99
12370489-5	2002	Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation.	Oxygen	144-150	BCL2 apoptosis regulator	Homo sapiens	14-19
12370489-5	2002	Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation.	Oxygen	144-150	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
12370489-5	2002	Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation.	Oxygen	144-150	cytochrome c, somatic	Homo sapiens	87-99
12370489-5	2002	Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation.	Oxygen	144-150	apoptotic peptidase activating factor 1	Homo sapiens	100-106
12370489-6	2002	Here we review what is currently known oxygen deprivation induced cell death and speculate about initiating mechanisms resulting in the activation of pro-apoptotic Bcl-2 family members.	Oxygen	39-45	BCL2 apoptosis regulator	Homo sapiens	164-169
12493070-2	2002	A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-1beta, and IFN-gamma.	Oxygen	32-38	interleukin 1 beta	Homo sapiens	198-206
12427234-5	2002	RESULTS: Retinal NPY mRNA expression was increased by 2.3-fold from P7 to P12, and 2.8-fold from P7 to P17 in oxygen-reared animals.	Oxygen	110-116	family with sequence similarity 72, member A	Mus musculus	103-106
12427234-8	2002	Retinal NPY Y2 expression in oxygen-reared animals increased by 2.8-fold from P7 to P12 and by 2.7-fold from P12 to P17.	Oxygen	29-35	family with sequence similarity 72, member A	Mus musculus	116-119
12458176-2	2002	The key regulator for this oxygen-dependent gene expression is the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of an alpha and a beta subunit.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-93
12493070-2	2002	A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-1beta, and IFN-gamma.	Oxygen	32-38	interferon gamma	Homo sapiens	212-221
12458176-2	2002	The key regulator for this oxygen-dependent gene expression is the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of an alpha and a beta subunit.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-100
12458176-5	2002	On the other hand, HIF-1alpha cannot be detected above a critical partial pressure of oxygen when it is subjected to rapid ubiquitinylation and proteasomal degradation.	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
12708795-3	2002	We hypothesise that secreted levels of VEGF are increased in cultures of trophoblast cells under lowered oxygen conditions while secreted levels of PlGFare alternatively regulated.	Oxygen	105-111	vascular endothelial growth factor A	Homo sapiens	39-43
12458176-7	2002	HIF-1 is not only a master regulator of oxygen homeostasis, it also appears to play a key role in tumor development as well as cardiovascular and ischemic diseases.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12458177-7	2002	In contrast, during re-warming, [Asc]p declines at a relatively rapid rate that peaks at the time of maximal O(2) consumption.	Oxygen	109-113	PYD and CARD domain containing	Homo sapiens	33-36
12708795-0	2002	Vascular endothelial growth factor and placental growth factor release in cultured trophoblast cells under different oxygen tensions.	Oxygen	117-123	vascular endothelial growth factor A	Homo sapiens	0-34
12708795-5	2002	There was a significant increase in the levels of VEGF secreted fromfirst trimester and term cytotrophoblast cells cultured under lowered oxygen conditions compared to the controls while there was a significant decrease in the secreted levels of PIGF in the same cell populations (as measured by ELISA).	Oxygen	138-144	vascular endothelial growth factor A	Homo sapiens	50-54
12708795-0	2002	Vascular endothelial growth factor and placental growth factor release in cultured trophoblast cells under different oxygen tensions.	Oxygen	117-123	placental growth factor	Homo sapiens	39-62
12558191-8	2002	IL-8 "hyper-responders" experienced significantly greater postoperative weight gain and had higher IL-8 levels at 24 h (p&lt;0.05), with trends towards renal impairment and protracted supplemental oxygen requirements.	Oxygen	197-203	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12409484-5	2002	Sensors include membrane proteins such as ionotropic ion channels, membrane or cytosolic heme proteins, mitochondrial proteins and/or oxygen sensitive transcription factors such as HIF-1alpha and NFkappaB.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	181-191
12553559-1	2002	Human spermatozoa are more dependent on glutathione peroxidase/glutathione reductase (GPX/GR) system, via reduced glutathione (GSH), to inactivate reactive oxygen metabolites (ROMs) such as hydrogen peroxide and organic hydroperoxides.	Oxygen	156-162	glutathione peroxidase 3	Homo sapiens	86-89
12590701-3	2002	The production of EPO is tightly modulated by the loss of oxygen and the hypoxia-inducible factor 1.	Oxygen	58-64	erythropoietin	Homo sapiens	18-21
12445170-0	2002	The effect of insulin and glucagon on splanchnic oxygen consumption.	Oxygen	49-55	insulin	Homo sapiens	14-21
12445170-1	2002	UNLABELLED: The purpose of these experiments was to measure the influence of insulin and glucagon on the splanchnic oxygen consumption.	Oxygen	116-122	insulin	Homo sapiens	77-84
12606820-8	2002	CONCLUSIONS: These results suggest that inhibition of the PI3K/Akt pathway can sensitize first-trimester trophoblast-like cells into oxygen-induced cell death and that EGF exerts its anti-apoptotic effect independently of PI3K/Akt.	Oxygen	133-139	AKT serine/threonine kinase 1	Homo sapiens	63-66
12510865-14	2002	Individuals with a high content of MyHC II in the vastus lateralis m. quadricipitisfemoris consume more oxygen in the pre-exercise conditions than subjects with a low content of MyHC II in their muscles.	Oxygen	104-110	myosin heavy chain 6	Homo sapiens	35-39
12510865-15	2002	Subjects with a high content of MyHC II require a smaller increase in VO2 for maintaining a linear increase in power output up to the lactate threshold (lower slope in this relationship), but after exceeding the LT, they consume more oxygen above that expected from the linear relationship below the LT, than the subjects with a low content of MyHC II in their muscles.	Oxygen	234-240	myosin heavy chain 6	Homo sapiens	32-36
12471320-7	2002	RESULTS: During treadmill testing, maximal oxygen consumption (VO2max) ranged from of 42.0 to 59.7 mL x kg(-1) x min(-1) (mean +/- SD = 47.6+/-8.1).	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	113-119
12479515-10	2002	RESULTS: For the entire cohort, peak exercise oxygen uptake was 19.9+/-4.8 mL x kg(-1) x min(-1) (61%+/-15% of age and sex predicted).	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	89-95
12516960-7	2002	In vitro, ET-2, ET-RA, and ET-RB mRNA were increased by incubating HTH-K cells in hypoxia (0.1% oxygen) for 24 h. Hypoxia also up-regulated ET-2 mRNA in several human breast tumor cell lines.	Oxygen	96-102	endothelin receptor type B	Homo sapiens	27-32
12434113-8	2002	Catalase is mainly found in the liver; it is active in the "antioxidative defense system" against toxic O2 metabolites.	Oxygen	104-106	catalase	Homo sapiens	0-8
12516032-8	2002	The reduced vascular permeability, resulting from inhibition of VEGF, led to increased delivery of oxygen and therapeutic agents to tumors.	Oxygen	99-105	vascular endothelial growth factor A	Homo sapiens	64-68
12464182-1	2002	Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12462562-1	2002	We previously showed that interleukin 1beta (IL-1beta) induces vasomotor shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	95-101	interleukin-1 beta	Oryctolagus cuniculus	26-43
12462562-1	2002	We previously showed that interleukin 1beta (IL-1beta) induces vasomotor shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	95-101	interleukin-1 beta	Oryctolagus cuniculus	45-53
12462562-1	2002	We previously showed that interleukin 1beta (IL-1beta) induces vasomotor shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	120-126	interleukin-1 beta	Oryctolagus cuniculus	26-43
12462562-1	2002	We previously showed that interleukin 1beta (IL-1beta) induces vasomotor shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits.	Oxygen	120-126	interleukin-1 beta	Oryctolagus cuniculus	45-53
12464182-1	2002	Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12376345-1	2002	The molecular mechanisms by which cells detect hypoxia (1.5% O2), resulting in the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein remain unclear.	Oxygen	61-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-131
12213816-7	2002	Furthermore, purified recombinant PKC protein fragments shed stoichiometric amounts of Zn(2+) upon reaction with diacylglycerol, phorbol ester, or reactive oxygen in vitro.	Oxygen	156-162	proline rich transmembrane protein 2	Homo sapiens	34-37
12385715-4	2002	The expression analysis of the MTL4 gene was demonstrated in free-living cells in the presence of Cd(2+) and Cu(2+), under the low oxygen condition.	Oxygen	131-137	metallothionein 1 pseudogene 3	Homo sapiens	31-35
12376345-1	2002	The molecular mechanisms by which cells detect hypoxia (1.5% O2), resulting in the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein remain unclear.	Oxygen	61-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
12376345-4	2002	In the present study, we investigated the role of mitochondria in regulating HIF-1alpha protein stabilization under anoxia (0% O2).	Oxygen	127-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
12433614-1	2002	BACKGROUND: We investigated whether vascular endothelial growth factor (VEGF) plays an important role in maintaining constant tumor growth in wasted elderly patients, in whom oxygen and glucose supply are often unable to meet the demands of the body.	Oxygen	175-181	vascular endothelial growth factor A	Homo sapiens	72-76
12485909-2	2002	The oxygen-dependent regulation of HIF-1 activity occurs at multiple levels in vivo.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
12220615-5	2002	Here, I describe the basic components of the intracellular oxidative/redox control machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors such as NF-kappaB and HIF-1alpha.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-205
12215449-3	2002	The female rats that had greater oxygen consumption showed higher UCP1 content, a higher multilocular arrangement, and both longer cristae and higher cristae dense mitochondria in BAT indicating heightened thermogenic capacity and activity; this picture is accompanied by a more sensitive beta(3)-AR to norepinephrine signal (EC(50) 10-fold lower for CGP12177A) and a lower expression of alpha(2A)-AR than male rats.	Oxygen	33-39	uncoupling protein 1	Rattus norvegicus	66-70
12398931-4	2002	The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels.	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-68
12398935-11	2002	These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2.	Oxygen	87-93	aryl-hydrocarbon receptor	Mus musculus	142-145
12398931-4	2002	The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels.	Oxygen	177-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
13677623-14	2002	SOD converts O2*- to H2O2, which is further converted to H2O with the help of GPx and CAT.	Oxygen	13-15	superoxide dismutase 1	Homo sapiens	0-3
12494887-2	2002	Vascular endothelial growth factor (VEGF) plays an important role in solid tumor angiogenesis by enhancing new blood vessel formation to transport nutrients and oxygen into tumors.	Oxygen	161-167	vascular endothelial growth factor A	Homo sapiens	0-34
12379927-8	2002	4MeOH, where Co(II) ion is in an octahedral environment of oxygen atoms.	Oxygen	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
12494887-2	2002	Vascular endothelial growth factor (VEGF) plays an important role in solid tumor angiogenesis by enhancing new blood vessel formation to transport nutrients and oxygen into tumors.	Oxygen	161-167	vascular endothelial growth factor A	Homo sapiens	36-40
12205091-2	2002	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a pivotal role in response to hypoxia by transcriptionally activating target genes involving oxygen uptake, transport, delivery, and consumption.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
12205091-2	2002	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a pivotal role in response to hypoxia by transcriptionally activating target genes involving oxygen uptake, transport, delivery, and consumption.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
12205091-3	2002	HIF-1alpha activity is regulated primarily through the ubiquitin-proteasome degradation pathway, which targets the oxygen-dependent degradation domain (ODD) of HIF-1alpha.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
12205091-3	2002	HIF-1alpha activity is regulated primarily through the ubiquitin-proteasome degradation pathway, which targets the oxygen-dependent degradation domain (ODD) of HIF-1alpha.	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
12409272-1	2002	Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase.	Oxygen	10-16	phospholipase A2	Ovis aries	20-36
12470895-6	2002	The daf-16 phenotype resembles that of mev-1 showing a short life and oxygen sensitivity.	Oxygen	70-76	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	39-44
12186875-1	2002	Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a regulator of gene expression under low oxygen conditions.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-47
12453408-0	2002	The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum.	Oxygen	13-17	ER oxidoreductin	Saccharomyces cerevisiae S288C	46-50
12453408-5	2002	Ero1p then uses molecular oxygen as its preferred terminal electron acceptor.	Oxygen	26-32	ER oxidoreductin	Saccharomyces cerevisiae S288C	0-5
12453408-6	2002	Thus Ero1p directly couples disulfide formation to the consumption of molecular oxygen, but its activity is modulated by free lumenal FAD levels, potentially linking disulfide formation to a cell"s nutritional or metabolic status.	Oxygen	80-86	ER oxidoreductin	Saccharomyces cerevisiae S288C	5-10
12506300-5	2002	Breathing 100% oxygen resulted in a significant decrease in catalase and Na+-K+ATPase activity and concentration of superoxide dismutase, glycine caused insignificant change of these enzymes after ischemia-index of lipid peroxidation and nitric oxide they were significantly elevated following reperfusion while rats breathed room air and further elevation was noticed after breathing 100% oxygen.	Oxygen	15-21	catalase	Rattus norvegicus	60-68
12430012-2	2002	At least in the case of plants and mammals, response at the level of the whole organism is a consequence of oxygen"s interaction with enzymes that should not exhibit oxygen sensitivity, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) and glutamate decarboxylase (GAD).	Oxygen	108-114	glutamate-ammonia ligase	Homo sapiens	248-271
12430012-2	2002	At least in the case of plants and mammals, response at the level of the whole organism is a consequence of oxygen"s interaction with enzymes that should not exhibit oxygen sensitivity, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) and glutamate decarboxylase (GAD).	Oxygen	108-114	glutamate-ammonia ligase	Homo sapiens	273-276
12186875-1	2002	Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a regulator of gene expression under low oxygen conditions.	Oxygen	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
12459261-1	2002	Hypoxia-inducible factor 1 is a heterodimeric transcription factor, made up of two subunits called HIF-1alpha and aryl receptor nuclear translocator, that regulates the expression of genes associated with adaptation to reduced oxygen pressure.	Oxygen	227-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
12239177-1	2002	Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O(2))-dependent manner.	Oxygen	122-128	erythropoietin	Homo sapiens	95-109
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	Oxygen	18-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12351415-7	2002	These results indicate that the neutrophil has a ferroprotein oxygen-sensing mechanism identical to that for erythropoietin regulation and results in HIF-1alpha up-regulation and profound but reversible inhibition of neutrophil apoptosis.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-160
12374623-2	2002	The extent of oxidative damage in AD brains correlates with the presence of the E4 allele of ApoE, suggesting an association between the ApoE4 genotype and oxygen-mediated damage in AD.	Oxygen	156-162	apolipoprotein E	Mus musculus	93-97
12397986-0	2002	First anionic silyl migration from sp2 carbon to carbonyl oxygen.	Oxygen	58-64	Sp2 transcription factor	Homo sapiens	35-38
12397986-2	2002	1,4-Silyl migration from sp2 carbon to carbonyl oxygen proceeded by the treatment of (Z)-beta-trimethylsilyl-alpha,beta-unsaturated ketones with copper(I) tert-alkoxide to afford vinylmetal species, which reacted with allylic halides to produce enol trimethylsilyl ethers of beta-alk-2-enyl-alpha,beta-unsaturated ketones with complete retention of configuration.	Oxygen	48-54	Sp2 transcription factor	Homo sapiens	25-28
12239177-1	2002	Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O(2))-dependent manner.	Oxygen	122-128	erythropoietin	Homo sapiens	111-114
12239177-1	2002	Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O(2))-dependent manner.	Oxygen	130-135	erythropoietin	Homo sapiens	95-109
12239177-1	2002	Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O(2))-dependent manner.	Oxygen	130-135	erythropoietin	Homo sapiens	111-114
12135701-4	2002	Hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappaB (NF-kappaB) are redox-sensitive transcription factors of particular importance because their differential activation by reducing and oxidizing signals, respectively, regulate the expression/suppression of O(2)-responsive genes.	Oxygen	276-280	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
12135701-4	2002	Hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappaB (NF-kappaB) are redox-sensitive transcription factors of particular importance because their differential activation by reducing and oxidizing signals, respectively, regulate the expression/suppression of O(2)-responsive genes.	Oxygen	276-280	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
12135701-4	2002	Hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappaB (NF-kappaB) are redox-sensitive transcription factors of particular importance because their differential activation by reducing and oxidizing signals, respectively, regulate the expression/suppression of O(2)-responsive genes.	Oxygen	276-280	nuclear factor kappa B subunit 1	Homo sapiens	72-81
12241538-2	2002	The present study examined the importance of body fatness and insulin sensitivity as variables that may be associated with muscle oxygen supply.	Oxygen	130-136	insulin	Homo sapiens	62-69
12677185-8	2002	Moreover, hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by reductions in oxygen concentration.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-36
12677185-8	2002	Moreover, hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by reductions in oxygen concentration.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-43
12238567-8	2002	Expression of CD18 rose significantly in the O2/endotoxin group after 4 hr, but thereafter did not differ from O2 controls.	Oxygen	45-47	integrin subunit beta 2	Rattus norvegicus	14-18
12355439-0	2002	IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension.	Oxygen	140-146	interferon gamma	Mus musculus	0-9
12215541-4	2002	We show that the bHLH-PAS proteins Similar (Sima) and Tango (Tgo) function as HIF-alpha and HIF-beta homologues, respectively, and demonstrate a conserved mode of regulation for Sima by oxygen.	Oxygen	186-192	similar	Drosophila melanogaster	44-48
12239605-3	2002	This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption.	Oxygen	80-86	agouti related neuropeptide	Mus musculus	56-60
12239605-5	2002	ICV administered AGRP (1 nmol/mouse) significantly decreased oxygen consumption compared to ACSF-treated controls.	Oxygen	61-67	agouti related neuropeptide	Mus musculus	17-21
12378005-0	2002	Oxygen-dependent and -independent regulation of HIF-1alpha.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
12378005-1	2002	Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1alpha and HIF-1beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12378005-1	2002	Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1alpha and HIF-1beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12378005-2	2002	Normally, the formation and transcriptional activity of HIF-1 depend on the amount of HIF-1alpha, and the expression of HIF-1alpha is tightly controlled by the cellular oxygen tension.	Oxygen	169-175	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
12378005-3	2002	Recent progress in the study of its regulation mechanism provided clues as to how HIF-1alpha is regulated by oxygen.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
12378005-4	2002	It appears that HIF-1alpha is not regulated only by the oxygen tension, but also by various other stimuli, such as transition metals, nitric oxide, reactive oxygen species, growth factors, and mechanical stresses.	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
12378005-5	2002	In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1alpha, and the respective physiological and pathological meanings.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
12536123-3	2002	Activation of HIF-1 in eukaryotes induces expression of many genes that assist in adapting the organism to an environment in which oxygen is limiting, such as of genes involved in new blood vessel formation, including isoforms of vascular endothelial growth factor and angiopoietins, among others.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
12536123-3	2002	Activation of HIF-1 in eukaryotes induces expression of many genes that assist in adapting the organism to an environment in which oxygen is limiting, such as of genes involved in new blood vessel formation, including isoforms of vascular endothelial growth factor and angiopoietins, among others.	Oxygen	131-137	vascular endothelial growth factor A	Homo sapiens	230-264
12324729-6	2002	The erythropoietin group had higher vascular resistance and mean arterial pressure values, lower intracerebral concentrations of glutamate and glycerol, higher brain tissue oxygen tension, and lower apoptotic index.	Oxygen	173-179	erythropoietin	Homo sapiens	4-18
12370842-1	2002	The purpose of the present study was to investigate the relationships among the resting systolic (SBP) and diastolic blood pressure (DBP) or SBP response during exercise with insulin resistance evaluated by a homeostasis model (HOMA-IR), abdominal fat accumulation (visceral fat area [VFA], subcutaneous fat area [SFA]) by computed tomography (CT), and an estimation of the maximal oxygen uptake (V*O2max) in 63 Japanese middle-aged male patients with type 2 diabetes mellitus (type 2 DM).	Oxygen	382-388	insulin	Homo sapiens	175-182
12215541-4	2002	We show that the bHLH-PAS proteins Similar (Sima) and Tango (Tgo) function as HIF-alpha and HIF-beta homologues, respectively, and demonstrate a conserved mode of regulation for Sima by oxygen.	Oxygen	186-192	similar	Drosophila melanogaster	78-87
12215541-4	2002	We show that the bHLH-PAS proteins Similar (Sima) and Tango (Tgo) function as HIF-alpha and HIF-beta homologues, respectively, and demonstrate a conserved mode of regulation for Sima by oxygen.	Oxygen	186-192	similar	Drosophila melanogaster	178-182
12242281-7	2002	Studies with GAL4-HIF-1alpha fusion proteins pinpointed the oxygen-dependent degradation domain as a critical target for the rapamycin-sensitive, mTOR-dependent signaling pathway leading to HIF-1alpha stabilization by CoCl(2).	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
12242281-7	2002	Studies with GAL4-HIF-1alpha fusion proteins pinpointed the oxygen-dependent degradation domain as a critical target for the rapamycin-sensitive, mTOR-dependent signaling pathway leading to HIF-1alpha stabilization by CoCl(2).	Oxygen	60-66	mechanistic target of rapamycin kinase	Homo sapiens	146-150
12215541-7	2002	Continuous ectopic expression overrode Sima degradation, which remained cytoplasmic in normoxia, and translocated to the nucleus only in hypoxia, revealing a second oxygen-regulated activation step.	Oxygen	165-171	similar	Drosophila melanogaster	39-43
12242281-7	2002	Studies with GAL4-HIF-1alpha fusion proteins pinpointed the oxygen-dependent degradation domain as a critical target for the rapamycin-sensitive, mTOR-dependent signaling pathway leading to HIF-1alpha stabilization by CoCl(2).	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	190-200
12428761-7	2002	One of these, the inducible cyclooxygenase-2 (COX-2), along with oxygen-starved mitochondria, comprise the major sources of ROS in the brain during hypoxia, ischemia, and reperfusion.	Oxygen	33-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-51
12428761-10	2002	Pro-inflammatory gene families that contribute to neurodegeneration are transiently activated in part by the heterodimeric oxygen-sensitive DNA-binding proteins nuclear factor for kappa B (NF-kappaB) and hypoxia-inducible factor-alpha (HIF-1alpha).	Oxygen	123-129	nuclear factor kappa B subunit 1	Homo sapiens	161-187
12428761-10	2002	Pro-inflammatory gene families that contribute to neurodegeneration are transiently activated in part by the heterodimeric oxygen-sensitive DNA-binding proteins nuclear factor for kappa B (NF-kappaB) and hypoxia-inducible factor-alpha (HIF-1alpha).	Oxygen	123-129	nuclear factor kappa B subunit 1	Homo sapiens	189-198
12428761-10	2002	Pro-inflammatory gene families that contribute to neurodegeneration are transiently activated in part by the heterodimeric oxygen-sensitive DNA-binding proteins nuclear factor for kappa B (NF-kappaB) and hypoxia-inducible factor-alpha (HIF-1alpha).	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	236-246
12356354-2	2002	VEGF is elevated in astrocytomas under normal oxygen conditions and undergoes induction in hypoxic stress.	Oxygen	46-52	vascular endothelial growth factor A	Homo sapiens	0-4
12371203-5	2002	Sonochemical generation of active oxygen species in the presence of EB, measured by ESR spectroscopy, was also inhibited by histidine.	Oxygen	34-40	esterase 5 regulator	Mus musculus	84-87
12372563-7	2002	If TNF-alpha treatment causes oxidative damage by compromising oxidative metabolism in oligodendrocytes, increasing products of lipid peroxidation and/or generating radical oxygen species that can interfere with maturation signals, CoQ(10) and NAC may protect oligodendrocytes by reversing one or more of those destructive processes during terminal maturation.	Oxygen	173-179	tumor necrosis factor	Homo sapiens	3-12
12400164-5	2002	The oxygen consumption was suppressed by superoxide dismutase and catalase, suggesting that superoxide and hydrogen peroxide could be generated in the reaction system.	Oxygen	4-10	catalase	Homo sapiens	66-74
12670123-0	2002	Exposure to increased pressure or hyperbaric oxygen suppresses interferon-gamma secretion in whole blood cultures of healthy humans.	Oxygen	45-51	interferon gamma	Homo sapiens	63-79
12095998-0	2002	Combinatorial control of yeast FET4 gene expression by iron, zinc, and oxygen.	Oxygen	71-77	Fet4p	Saccharomyces cerevisiae S288C	31-35
12237125-1	2002	Hypoxia increases the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and induces transcription of a variety of genes including vascular endothelial growth factor (VEGF) gene through oxygen sensing mechanisms.	Oxygen	196-202	vascular endothelial growth factor A	Homo sapiens	141-175
12237125-1	2002	Hypoxia increases the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and induces transcription of a variety of genes including vascular endothelial growth factor (VEGF) gene through oxygen sensing mechanisms.	Oxygen	196-202	vascular endothelial growth factor A	Homo sapiens	177-181
12237125-1	2002	Hypoxia increases the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and induces transcription of a variety of genes including vascular endothelial growth factor (VEGF) gene through oxygen sensing mechanisms.	Oxygen	196-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
12095998-10	2002	Finally, FET4 expression is regulated in response to oxygen by the Rox1 repressor.	Oxygen	53-59	Fet4p	Saccharomyces cerevisiae S288C	9-13
12095998-10	2002	Finally, FET4 expression is regulated in response to oxygen by the Rox1 repressor.	Oxygen	53-59	Rox1p	Saccharomyces cerevisiae S288C	67-71
12095998-13	2002	Thus, Fet4 is a multisubstrate metal ion transporter under combinatorial control by iron, zinc, and oxygen.	Oxygen	100-106	Fet4p	Saccharomyces cerevisiae S288C	6-10
12197759-6	2002	Our calculations indicate that, in the AChE-ACh Michaelis complex, only two hydrogen bonds are formed between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122.	Oxygen	123-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
12363340-2	2002	Limitation of the dissolved oxygen supplied during cultivation of various microbial strains can decrease the activity of cytochrome P-450 monooxygenases required for the processing of pathway intermediates into their final forms, resulting in the accumulation of these intermediates as the primary products.	Oxygen	28-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137
12213597-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis.	Oxygen	106-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12213597-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis.	Oxygen	106-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12213597-2	2002	HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation.	Oxygen	49-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12213597-2	2002	HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation.	Oxygen	95-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12213597-3	2002	HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal transduction pathways.	Oxygen	44-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12210984-3	2002	Two important factors that strongly influence the affinity to E. coli adhesin are: 1) the presence of an alpha-oriented aglycon that has a long aliphatic chain or an aromatic group immediately next to the glycosyl oxygen, and 2) the presence of multiple mannosyl residues that can span a distance of 20 nm or longer on a relatively inflexible structure.	Oxygen	214-220	adhesin	Escherichia coli	70-77
12380952-5	2002	Increased intracellular iron may also have a role in the inhibition of erythropoietin production, since the oxygen sensor is a hemoprotein.	Oxygen	108-114	erythropoietin	Homo sapiens	71-85
12208766-1	2002	Hypoxia-inducible factor 1 (HIF-1), a heterodimer of HIF-1alpha and HIF-1beta subunits, is a transcriptional activator central to the cellular response to low oxygen that includes metabolic adaptation, angiogenesis, metastasis, and inhibited apoptosis.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12208766-1	2002	Hypoxia-inducible factor 1 (HIF-1), a heterodimer of HIF-1alpha and HIF-1beta subunits, is a transcriptional activator central to the cellular response to low oxygen that includes metabolic adaptation, angiogenesis, metastasis, and inhibited apoptosis.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12352515-9	2002	IGF-1 treatment did not alter amino acid concentration in blood or amniotic fluid, but reduced gut uptake of glutamine from blood and the gut glutamine:oxygen quotient by 15%.	Oxygen	152-158	insulin like growth factor 1	Homo sapiens	0-5
12218958-3	2002	Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen.	Oxygen	100-106	superoxide dismutase 1	Homo sapiens	0-20
12218958-3	2002	Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen.	Oxygen	100-106	superoxide dismutase 1	Homo sapiens	22-25
12218958-3	2002	Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen.	Oxygen	132-138	superoxide dismutase 1	Homo sapiens	0-20
12218958-3	2002	Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen.	Oxygen	132-138	superoxide dismutase 1	Homo sapiens	22-25
12213874-8	2002	This increase may be related to low oxygen tension, as VEGF-A is up-regulated by hypoxia.	Oxygen	36-42	vascular endothelial growth factor A	Homo sapiens	55-61
12456992-10	2002	Hence, imidazoline compounds may protect beta cells against damage caused by IL-1beta-induced free oxygen and nitrogen radicals.	Oxygen	99-105	interleukin 1 beta	Rattus norvegicus	77-85
12052835-8	2002	These findings demonstrate that disruption of Hsp90 function 1) promotes HIF-1 alpha degradation via a novel, oxygen-independent E3 ubiquitin ligase and 2) diminishes HIF-1 alpha transcriptional activity.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-84
12243358-1	2002	At a low-oxygen tension, cells increase the expression of several genes (such as erythropoietin, the vascular endothelial growth factor, and glycolytic enzymes) in order to adapt to hypoxic stress.	Oxygen	9-15	erythropoietin	Homo sapiens	81-95
12243358-1	2002	At a low-oxygen tension, cells increase the expression of several genes (such as erythropoietin, the vascular endothelial growth factor, and glycolytic enzymes) in order to adapt to hypoxic stress.	Oxygen	9-15	vascular endothelial growth factor A	Homo sapiens	101-135
12126693-4	2002	This is the proposed role for ROS in oxygen sensing in systems, such as carotid body chemoreceptor cells, pulmonary artery smooth muscle cells, and erythropoietin-producing cells.	Oxygen	37-43	erythropoietin	Homo sapiens	148-162
12050149-4	2002	In comparison with native cyt c, the mass spectra obtained from the HOCl-treated cyt c revealed that oxygen is covalently incorporated into the protein as indicated by molecular ions of m/z = 12,360 (cyt c), 12,376 (cyt c + O), and 12,392 (cyt c + 2O).	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	26-31
12050149-4	2002	In comparison with native cyt c, the mass spectra obtained from the HOCl-treated cyt c revealed that oxygen is covalently incorporated into the protein as indicated by molecular ions of m/z = 12,360 (cyt c), 12,376 (cyt c + O), and 12,392 (cyt c + 2O).	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	81-86
12050149-4	2002	In comparison with native cyt c, the mass spectra obtained from the HOCl-treated cyt c revealed that oxygen is covalently incorporated into the protein as indicated by molecular ions of m/z = 12,360 (cyt c), 12,376 (cyt c + O), and 12,392 (cyt c + 2O).	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	81-86
12050149-4	2002	In comparison with native cyt c, the mass spectra obtained from the HOCl-treated cyt c revealed that oxygen is covalently incorporated into the protein as indicated by molecular ions of m/z = 12,360 (cyt c), 12,376 (cyt c + O), and 12,392 (cyt c + 2O).	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	81-86
12050149-4	2002	In comparison with native cyt c, the mass spectra obtained from the HOCl-treated cyt c revealed that oxygen is covalently incorporated into the protein as indicated by molecular ions of m/z = 12,360 (cyt c), 12,376 (cyt c + O), and 12,392 (cyt c + 2O).	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	81-86
12203292-3	2002	The reaction is a potential source of stratospheric ozone, in that O(3) (+) ions are known to undergo efficient charge exchange with oxygen to yield neutral O(3).	Oxygen	133-139	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	67-71
12050149-5	2002	Using tandem mass spectrometry, a peptide (obtained from the tryptic digests of HOCl-treated cyt c) corresponding to the amino acid sequence MIFAGIK, which contains the methionine that binds to the heme, was identified to be involved in the oxygen incorporation.	Oxygen	241-247	cytochrome c, somatic	Homo sapiens	93-98
12050149-10	2002	HOCl-oxidized cyt c also displayed an impaired ability to support oxygen consumption by the purified mitochondrial cytochrome c oxidase, suggesting that protein oxidation of cyt c may break the electron transport chain and inhibit energy transduction in mitochondria.	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	14-19
12050149-10	2002	HOCl-oxidized cyt c also displayed an impaired ability to support oxygen consumption by the purified mitochondrial cytochrome c oxidase, suggesting that protein oxidation of cyt c may break the electron transport chain and inhibit energy transduction in mitochondria.	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	115-127
12050149-10	2002	HOCl-oxidized cyt c also displayed an impaired ability to support oxygen consumption by the purified mitochondrial cytochrome c oxidase, suggesting that protein oxidation of cyt c may break the electron transport chain and inhibit energy transduction in mitochondria.	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	174-179
12163023-3	2002	Under normoxia, two highly conserved proline residues within the oxygen-dependent degradation domain (ODDD) are hydroxylated by oxoglutarate-dependent proline 4-hydroxylases EGLN1-3.	Oxygen	65-71	egl-9 family hypoxia inducible factor 1	Homo sapiens	174-179
12203292-3	2002	The reaction is a potential source of stratospheric ozone, in that O(3) (+) ions are known to undergo efficient charge exchange with oxygen to yield neutral O(3).	Oxygen	133-139	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	157-161
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Oxygen	332-338	cannabinoid receptor 1	Homo sapiens	38-41
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Oxygen	178-184	cannabinoid receptor 1	Homo sapiens	386-389
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Oxygen	178-184	cannabinoid receptor 1	Homo sapiens	38-41
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Oxygen	332-338	cannabinoid receptor 1	Homo sapiens	386-389
12153971-8	2002	However, Sa(O(2)) with ascent was significantly associated with the ACE genotype in the rapid ascent group (p = 0.01) with a relatively sustained Sa(O(2)) in the II subjects.	Oxygen	12-16	angiotensin I converting enzyme	Homo sapiens	68-71
12048208-4	2002	Recombinant Drosophila hemoglobin displays a typical hexacoordinated deoxy spectrum and binds oxygen with an affinity of 0.12 torr.	Oxygen	94-100	globin 1	Drosophila melanogaster	23-33
12048208-8	2002	This suggests that oxygen supply in insects may be more complex than thought previously and may depend on hemoglobin-mediated oxygen transport and storage in addition to simple diffusion.	Oxygen	19-25	globin 1	Drosophila melanogaster	106-116
12048208-8	2002	This suggests that oxygen supply in insects may be more complex than thought previously and may depend on hemoglobin-mediated oxygen transport and storage in addition to simple diffusion.	Oxygen	126-132	globin 1	Drosophila melanogaster	106-116
12146979-1	2002	Stearoyl acyl carrier protein Delta(9) desaturase catalyzes the NADPH- and O(2)-dependent insertion of a cis double bond between the C-9 and C-10 positions of the acyl chain in the kinetically preferred natural substrate 18:0-ACP.	Oxygen	75-79	homeobox C10	Homo sapiens	141-145
12127082-7	2002	Mitochondria isolated from UCP1-injected muscles showed a significant increase in state 2 and state 4 oxygen consumption rates and a decreased respiration control ratio in comparison to mitochondria from control muscles.	Oxygen	102-108	uncoupling protein 1	Rattus norvegicus	27-31
12124396-3	2002	One sequence was adjacent to and the other coincided with the two proline residues of the oxygen-dependent degradation domain (P402 and P564) that act as switches for the oxygen-dependent regulation of HIF-1alpha.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	202-212
12124396-3	2002	One sequence was adjacent to and the other coincided with the two proline residues of the oxygen-dependent degradation domain (P402 and P564) that act as switches for the oxygen-dependent regulation of HIF-1alpha.	Oxygen	171-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	202-212
12193088-6	2002	Furthermore, a higher oxygen content (50%) decreased drastically the expression of GAPDH, HIF-1 alpha and endothelin-1 (ET-1), and increased [(3)H]palmitate uptake.	Oxygen	22-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	83-88
12230874-2	2002	The inducible heme oxygenase-1 gene, ho-1, responds dramatically to changes in cellular redox potential provoked by multiple agents (oxidants, xenobiotics, reactive oxygen species, nitric oxide, and ultraviolet-A radiation) as well as deviations in oxygen tension in excess or deficit of normal physiological levels.	Oxygen	19-25	heme oxygenase 1	Mus musculus	37-41
12154057-13	2002	These interdependent pathways function at a lowered O(2) concentration that is, however, above that necessary for HIF-1 alpha stabilization.	Oxygen	52-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-125
12230874-8	2002	This review will examine the potential roles of iron, glutathione, and reactive oxygen species in the upstream events leading to ho-1 activation following oxygen related stress.	Oxygen	80-86	heme oxygenase 1	Mus musculus	129-133
12230876-0	2002	Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo.	Oxygen	58-64	heparin-binding EGF-like growth factor	Rattus norvegicus	0-38
12230876-0	2002	Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo.	Oxygen	58-64	heparin-binding EGF-like growth factor	Rattus norvegicus	40-46
12154035-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12154035-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12193080-1	2002	A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development of atherosclerosis.	Oxygen	29-35	endothelin 1	Homo sapiens	89-93
12193088-6	2002	Furthermore, a higher oxygen content (50%) decreased drastically the expression of GAPDH, HIF-1 alpha and endothelin-1 (ET-1), and increased [(3)H]palmitate uptake.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-101
12193088-6	2002	Furthermore, a higher oxygen content (50%) decreased drastically the expression of GAPDH, HIF-1 alpha and endothelin-1 (ET-1), and increased [(3)H]palmitate uptake.	Oxygen	22-28	endothelin 1	Homo sapiens	106-118
12193088-6	2002	Furthermore, a higher oxygen content (50%) decreased drastically the expression of GAPDH, HIF-1 alpha and endothelin-1 (ET-1), and increased [(3)H]palmitate uptake.	Oxygen	22-28	endothelin 1	Homo sapiens	120-124
12177505-1	2002	The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol can be diverted to oxygen via the alternative oxidase (AOX).	Oxygen	113-119	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	128-147
12163811-15	2002	Hemoglobin-based oxygen carriers can adequately serve as initial therapy to maintain tissue oxygen delivery while awaiting the maximal effect of recombinant erythropoietin on bone marrow red blood cell production.	Oxygen	17-23	erythropoietin	Homo sapiens	157-171
12212959-6	2002	Pa,O2 increased to acceptable levels with an O2 supply of 2 L x min(-1) at rest and 4 L x min(-1) during 20 W exercise.	Oxygen	3-5	CD59 molecule (CD59 blood group)	Homo sapiens	64-70
12212959-6	2002	Pa,O2 increased to acceptable levels with an O2 supply of 2 L x min(-1) at rest and 4 L x min(-1) during 20 W exercise.	Oxygen	3-5	CD59 molecule (CD59 blood group)	Homo sapiens	90-96
12212959-6	2002	Pa,O2 increased to acceptable levels with an O2 supply of 2 L x min(-1) at rest and 4 L x min(-1) during 20 W exercise.	Oxygen	45-47	CD59 molecule (CD59 blood group)	Homo sapiens	64-70
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	vascular endothelial growth factor A	Homo sapiens	63-97
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	vascular endothelial growth factor A	Homo sapiens	99-103
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	AKT serine/threonine kinase 1	Homo sapiens	152-155
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	AKT serine/threonine kinase 1	Homo sapiens	174-177
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	mitogen-activated protein kinase 3	Homo sapiens	184-223
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	mitogen-activated protein kinase 3	Homo sapiens	225-229
12214668-8	2002	A study of AQ4N metabolism in vitro and ex vivo using purified CYP enzymes, phenotyped human livers and CYP transfected cell lines shows that CYP3A, 1A and 1B1 family members contribute to AQ4N bioreduction in the absence of oxygen.	Oxygen	225-231	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66
12214669-4	2002	By contrast, NO synthase (NOS) containing BH4 catalyze the selective monooxygenation of some N-hydroxyguanidines by NADPH and O2 with formation of NO and the corresponding ureas in a 1:1 molar ratio.	Oxygen	126-128	nitric oxide synthase 2	Homo sapiens	13-24
12153983-1	2002	Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic.	Oxygen	43-49	erythropoietin	Homo sapiens	122-136
12153983-2	2002	The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF alpha subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing.	Oxygen	174-180	erythropoietin	Homo sapiens	131-145
12153983-2	2002	The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF alpha subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing.	Oxygen	308-314	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
12177505-1	2002	The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol can be diverted to oxygen via the alternative oxidase (AOX).	Oxygen	113-119	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	149-152
12195866-2	2002	Hypoxia-inducible factor-1 (HIF-1) is activated by low oxygen tension in all mammalian cells and underpins many aspects of the impressive ability to match oxygen supply and demand.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12119234-1	2002	Endothelin-1 (ET-1) mediates the development of pulmonary hypertension (PHT) in newborn rats exposed to 60% O(2) for 14 days, a model for human chronic neonatal lung injury.	Oxygen	108-112	endothelin 1	Rattus norvegicus	0-12
12119234-1	2002	Endothelin-1 (ET-1) mediates the development of pulmonary hypertension (PHT) in newborn rats exposed to 60% O(2) for 14 days, a model for human chronic neonatal lung injury.	Oxygen	108-112	endothelin 1	Rattus norvegicus	14-18
12119234-6	2002	Lung ET-1 content was significantly reduced by L670596 in 60% O(2)-exposed animals.	Oxygen	62-66	endothelin 1	Rattus norvegicus	5-9
12055086-1	2002	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of HIF-1alpha and HIF-1beta subunits, controls the expression of a large number of genes involved in the regulation of cellular responses to reduced oxygen availability.	Oxygen	233-239	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12055086-1	2002	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of HIF-1alpha and HIF-1beta subunits, controls the expression of a large number of genes involved in the regulation of cellular responses to reduced oxygen availability.	Oxygen	233-239	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12055086-2	2002	The oxygen-regulated subunit, HIF-1alpha, is stabilized in cells exposed to hypoxia.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
12063290-3	2002	NE and ANG II increased oxygen and glucose uptake as well as hindlimb lactate release by 50%.	Oxygen	24-30	angiotensinogen	Rattus norvegicus	7-13
12402447-3	2002	The duration of the exercise for the children in the obesity group was significantly shorter than controls (P = 0.010) but obese children have greater absolute values for oxygen uptake (VO2peak ml min-1 = 1907 +/- 671 versus 1495 +/- 562; P = 0.013) and ventilatory variables (VE, VT), which adjusted for body mass decrease significantly (VO2/kg ml min-1 kg-1 = 29.2 +/- 3.8 versus 33.6 +/- 3.5; P &lt; 0.001).	Oxygen	171-177	CD59 molecule (CD59 blood group)	Homo sapiens	197-202
12402451-5	2002	However, the higher value in HRVI was found in group A. Maximal oxygen consumption (VO2max) was 62.0 +/- 4.4 ml kg-1 min-1 in group A, 52.7 +/- 6.0 in group B, 44.6 +/- 5.3 in C and 41.6 +/- 6.0 in D. The higher value in VO2max was also found in group A.	Oxygen	64-70	CD59 molecule (CD59 blood group)	Homo sapiens	117-122
12175540-2	2002	Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to hypoxia (1% O2) and rapidly degraded when cells are re-oxygenated.	Oxygen	124-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
12175540-2	2002	Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to hypoxia (1% O2) and rapidly degraded when cells are re-oxygenated.	Oxygen	124-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-15
12175540-6	2002	Mechanisms involved in sustaining constitutive expression of HIF-1alpha protein in malignant cells at normal oxygen tension warrant further investigation.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
12099689-2	2002	Using a Hep3B cell-derived cell line, HRE7 cells, we found that the inhibition of HIF-1alpha activity by NO requires a substantial amount of oxygen, albeit at a lower level.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
12099689-3	2002	We further investigated the effect of NO on the binding activity of the von Hippel-Lindau tumor suppressor protein (pVHL) to the N-terminal activation domain (NAD) overlapping the oxygen-dependent degradation domain (ODD) of HIF-1alpha, because this reaction involves prolyl hydroxylation in NAD that requires oxygen.	Oxygen	180-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	225-235
12099689-3	2002	We further investigated the effect of NO on the binding activity of the von Hippel-Lindau tumor suppressor protein (pVHL) to the N-terminal activation domain (NAD) overlapping the oxygen-dependent degradation domain (ODD) of HIF-1alpha, because this reaction involves prolyl hydroxylation in NAD that requires oxygen.	Oxygen	310-316	hypoxia inducible factor 1 subunit alpha	Homo sapiens	225-235
12147561-11	2002	Peak oxygen uptake increased from 18.1 to 19.7 ml x kg(-1) x min(-1) in the strength and from 17.1 to 18.2 in the endurance group (non-significant).	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	61-67
12117343-9	2002	The SOS index significantly correlated with the Epworth Sleepiness Scale (r = - 0.42; P&lt;.001) and the global Pittsburgh Sleep Quality Index score (r = - 0.38; P&lt;.001), as well as with the number of recorded arterial oxygen saturation levels below 85% (r = - 0.46; P =.02).	Oxygen	222-228	xylosyltransferase 2	Homo sapiens	4-7
12195866-2	2002	Hypoxia-inducible factor-1 (HIF-1) is activated by low oxygen tension in all mammalian cells and underpins many aspects of the impressive ability to match oxygen supply and demand.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12195866-2	2002	Hypoxia-inducible factor-1 (HIF-1) is activated by low oxygen tension in all mammalian cells and underpins many aspects of the impressive ability to match oxygen supply and demand.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12195866-2	2002	Hypoxia-inducible factor-1 (HIF-1) is activated by low oxygen tension in all mammalian cells and underpins many aspects of the impressive ability to match oxygen supply and demand.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12195866-5	2002	This review describes how HIF-1 is regulated by oxygen and the central role played by the von Hippel-Lindau tumour suppressor protein.	Oxygen	48-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
12195866-6	2002	The underlying oxygen sensor is provided by a family of enzymes which oxidize specific proline residues in HIF alpha subunits.	Oxygen	15-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-116
12195866-7	2002	Inhibiting these newly discovered enzymes provides a way of activating HIF-1 in the presence of oxygen--an exciting prospect for therapeutic intervention in ischaemic diseases.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-76
12079454-8	2002	In it, there exist mononuclear octahedral sites of Co(II) surrounded by oxygens, belonging to terminal phosphonates and bound water molecules.	Oxygen	72-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12079454-11	2002	The magnetic and EPR data on 1 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin S = (1)/(2).	Oxygen	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
12068004-0	2002	Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption.	Oxygen	96-102	insulin	Homo sapiens	0-7
12136249-4	2002	Enhanced HIF-1alpha expression during hypoxia results from a drastic reduction of its degradation rate within a critical region of the protein referred to as the "oxygen-dependent degradation (ODD) domain".	Oxygen	163-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
12297333-7	2002	The protein levels and activity of CuZn SOD did not changed by 60% oxygen inhalation although the mRNA level was increased to 4.7-fold at 2 weeks of oxygen exposure.	Oxygen	149-155	superoxide dismutase 1	Rattus norvegicus	35-43
12212314-1	2002	PURPOSE: The purpose of this study was to investigate the relationship between ADL and residential environment for patients receiving home oxygen therapy.	Oxygen	139-145	sarcoglycan alpha	Homo sapiens	79-82
12112237-2	2002	Under aerobic conditions oxygen control of gene expression is exerted through the activator Hap1 and the repressor Rox1.	Oxygen	25-31	Rox1p	Saccharomyces cerevisiae S288C	115-119
14602992-4	2002	In a recent study published in Science Express on 13 June 2002, researchers screened for Caenorhabditis elegans mutants that survive in a low-oxygen environment and identified a number of daf-2 mutants that are resistant to hypoxia.	Oxygen	142-148	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	188-193
12132518-0	2002	Transient increase in endothelin-1 levels in the pulmonary circulation during exercise while breathing of oxygen in patients with chronic obstructive pulmonary disease.	Oxygen	106-112	endothelin 1	Homo sapiens	22-34
12132518-8	2002	In contrast, while breathing oxygen, ET-1 levels were significantly higher just after exercise [4.41 (0.43) pg/ml] than at rest [3.90 (0.37) pg/ml, p=0.0116] and 1 hour after exercise [3.93 (0.38) pg/ml, p=0.0246].	Oxygen	29-35	endothelin 1	Homo sapiens	37-41
12132518-12	2002	However, oxygen supplementation reversed the capacity of ET-1 release, and delta ET-1 with exercise was negatively correlated with delta mPAP.	Oxygen	9-15	endothelin 1	Homo sapiens	57-61
12124431-0	2002	Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer"s disease amyloid.	Oxygen	23-29	amyloid beta precursor protein	Homo sapiens	73-78
12127821-4	2002	RESULTS: The electrophoretic mobility shift assay detected increased HIF-1 DNA-binding activity in each cell line within 2 h of hypoxia (1% O2).	Oxygen	140-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	219-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	219-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
12127821-5	2002	HIF-1 binding was maximal within 4 h and remained stable for 24 h. HIF-1 DNA-binding activity was maximal in the established IEC-6 cell line below 2% oxygen, but HIF-1 DNA-binding activity was not detectable above 0.5% O2 in the primary human FHs 74 Int cell line.	Oxygen	219-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
12127821-7	2002	CONCLUSIONS: In conclusion, HIF-1 regulates gene expression in enterocytes and an undefined phosphorylation event is important for O2 sensing.	Oxygen	131-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
14993394-3	2002	Oxygen-dependent hydroxylation of conserved proline and asparagine residues in HIF-alpha are required for targeting HIF-alpha to proteasomes for destruction, and for inhibiting its capacity for CBP/p300-dependent transactivation, respectively.	Oxygen	0-6	CREB binding protein	Homo sapiens	194-202
12095139-6	2002	Splanchnic oxygen consumption increased in cardiac surgery patients from 39 (5) mL x min(-1) x m(-2) to 46 (6) mL x min(-1) x m(-2) (P = 0.003) but decreased in septic patients from 61 (19) mL x min(-1) x m(-2) to 51 (17) L x min(-1) x m(-2) (p = 0.021).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	85-91
12095139-6	2002	Splanchnic oxygen consumption increased in cardiac surgery patients from 39 (5) mL x min(-1) x m(-2) to 46 (6) mL x min(-1) x m(-2) (P = 0.003) but decreased in septic patients from 61 (19) mL x min(-1) x m(-2) to 51 (17) L x min(-1) x m(-2) (p = 0.021).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
12095139-6	2002	Splanchnic oxygen consumption increased in cardiac surgery patients from 39 (5) mL x min(-1) x m(-2) to 46 (6) mL x min(-1) x m(-2) (P = 0.003) but decreased in septic patients from 61 (19) mL x min(-1) x m(-2) to 51 (17) L x min(-1) x m(-2) (p = 0.021).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
12095139-6	2002	Splanchnic oxygen consumption increased in cardiac surgery patients from 39 (5) mL x min(-1) x m(-2) to 46 (6) mL x min(-1) x m(-2) (P = 0.003) but decreased in septic patients from 61 (19) mL x min(-1) x m(-2) to 51 (17) L x min(-1) x m(-2) (p = 0.021).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
12050673-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic homeostatic responses to oxygen availability.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12050673-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic homeostatic responses to oxygen availability.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12050673-3	2002	HIF-1 alpha is stable in hypoxia, but in the presence of oxygen it is targeted for proteasomal degradation by the ubiquitination complex pVHL, the protein of the von Hippel Lindau (VHL) tumour suppressor gene and a component of an E3 ubiquitin ligase complex.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
12051660-2	2002	Having previously noted that NO- can reduce Cu (II), Zn SOD aerobically, we now report that it also can do so anaerobically and that Cu, Zn SOD can catalyze the elimination of NO(-) in the absence of O2.NO- acts as a reductant of ferricytochrome c anaerobically, but in the presence of O2 causes the oxidation of ferrocytochrome c and NADPH.	Oxygen	200-202	superoxide dismutase 1	Homo sapiens	140-143
12051660-2	2002	Having previously noted that NO- can reduce Cu (II), Zn SOD aerobically, we now report that it also can do so anaerobically and that Cu, Zn SOD can catalyze the elimination of NO(-) in the absence of O2.NO- acts as a reductant of ferricytochrome c anaerobically, but in the presence of O2 causes the oxidation of ferrocytochrome c and NADPH.	Oxygen	286-288	superoxide dismutase 1	Homo sapiens	140-143
12051660-3	2002	Equivalent fluxes of NO-, and NO + O2- were able to comparably oxidize NADPH, but the oxidation by NO + O2- was more than fivefold more sensitive to inhibition by Cu, Zn SOD than was the oxidation by NO-.	Oxygen	35-37	superoxide dismutase 1	Homo sapiens	170-173
12051660-3	2002	Equivalent fluxes of NO-, and NO + O2- were able to comparably oxidize NADPH, but the oxidation by NO + O2- was more than fivefold more sensitive to inhibition by Cu, Zn SOD than was the oxidation by NO-.	Oxygen	104-106	superoxide dismutase 1	Homo sapiens	170-173
12051660-4	2002	Thus Cu, Zn SOD inhibited NADPH oxidation by NO- by a route independent of catalyzing the dismutation of O2.	Oxygen	105-107	superoxide dismutase 1	Homo sapiens	12-15
12055253-0	2002	Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygen-dependent pathway.	Oxygen	136-142	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
12055253-0	2002	Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygen-dependent pathway.	Oxygen	136-142	BCL2 like 1	Homo sapiens	122-128
12068004-6	2002	The oxygen consumption rate of tumor cells after in vivo insulin infusion was measured using high frequency electron paramagnetic resonance oximetry.	Oxygen	4-10	insulin	Homo sapiens	57-64
12068004-9	2002	We found that the insulin-induced increase of tumor pressure of oxygen: (a) is not caused by an increase in the tumor blood flow, which is even decreased after insulin infusion; (b) is because of a decrease in the tumor cell oxygen consumption (in vivo insulin consumed oxygen three times slower than control cells); and (c) is inhibited by a nitric oxide (NO) synthase inhibitor, Nomega-nitro-L-arginine methyl ester, when injected i.p.	Oxygen	64-70	insulin	Homo sapiens	18-25
12068004-9	2002	We found that the insulin-induced increase of tumor pressure of oxygen: (a) is not caused by an increase in the tumor blood flow, which is even decreased after insulin infusion; (b) is because of a decrease in the tumor cell oxygen consumption (in vivo insulin consumed oxygen three times slower than control cells); and (c) is inhibited by a nitric oxide (NO) synthase inhibitor, Nomega-nitro-L-arginine methyl ester, when injected i.p.	Oxygen	64-70	insulin	Homo sapiens	160-167
12077180-12	2002	Because aggregated Abeta is known to be an oxygen radical generator, our results provide a novel concept that the aggregation-dependent biological effects of Abeta are dualistic, being either an oxygen radical generator or its inhibitor.	Oxygen	43-49	amyloid beta precursor protein	Homo sapiens	19-24
12077180-12	2002	Because aggregated Abeta is known to be an oxygen radical generator, our results provide a novel concept that the aggregation-dependent biological effects of Abeta are dualistic, being either an oxygen radical generator or its inhibitor.	Oxygen	43-49	amyloid beta precursor protein	Homo sapiens	158-163
12068004-9	2002	We found that the insulin-induced increase of tumor pressure of oxygen: (a) is not caused by an increase in the tumor blood flow, which is even decreased after insulin infusion; (b) is because of a decrease in the tumor cell oxygen consumption (in vivo insulin consumed oxygen three times slower than control cells); and (c) is inhibited by a nitric oxide (NO) synthase inhibitor, Nomega-nitro-L-arginine methyl ester, when injected i.p.	Oxygen	64-70	insulin	Homo sapiens	160-167
12077180-12	2002	Because aggregated Abeta is known to be an oxygen radical generator, our results provide a novel concept that the aggregation-dependent biological effects of Abeta are dualistic, being either an oxygen radical generator or its inhibitor.	Oxygen	195-201	amyloid beta precursor protein	Homo sapiens	19-24
12077180-12	2002	Because aggregated Abeta is known to be an oxygen radical generator, our results provide a novel concept that the aggregation-dependent biological effects of Abeta are dualistic, being either an oxygen radical generator or its inhibitor.	Oxygen	195-201	amyloid beta precursor protein	Homo sapiens	158-163
12068004-9	2002	We found that the insulin-induced increase of tumor pressure of oxygen: (a) is not caused by an increase in the tumor blood flow, which is even decreased after insulin infusion; (b) is because of a decrease in the tumor cell oxygen consumption (in vivo insulin consumed oxygen three times slower than control cells); and (c) is inhibited by a nitric oxide (NO) synthase inhibitor, Nomega-nitro-L-arginine methyl ester, when injected i.p.	Oxygen	225-231	insulin	Homo sapiens	18-25
12068004-9	2002	We found that the insulin-induced increase of tumor pressure of oxygen: (a) is not caused by an increase in the tumor blood flow, which is even decreased after insulin infusion; (b) is because of a decrease in the tumor cell oxygen consumption (in vivo insulin consumed oxygen three times slower than control cells); and (c) is inhibited by a nitric oxide (NO) synthase inhibitor, Nomega-nitro-L-arginine methyl ester, when injected i.p.	Oxygen	225-231	insulin	Homo sapiens	18-25
12060808-3	2002	In the present study, we examined the effects of PBN on the regulation of the mitogen activated kinase Erk and as well as Src family tyrosine kinases, enzymes known to be activated by oxygen species such as H2O2.	Oxygen	184-190	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	122-125
12049845-1	2002	Four terpenylnaphthoquinones were found to enhance the rate of superoxide production in the presence of ascorbate as detected from the superoxide dismutase (SOD)-inhibitable initial oxygen consumption rates.	Oxygen	182-188	superoxide dismutase 1	Homo sapiens	135-155
12049845-1	2002	Four terpenylnaphthoquinones were found to enhance the rate of superoxide production in the presence of ascorbate as detected from the superoxide dismutase (SOD)-inhibitable initial oxygen consumption rates.	Oxygen	182-188	superoxide dismutase 1	Homo sapiens	157-160
12003831-2	2002	Maximum oxygen uptake increased from 46 +/- 6 to 54 +/- 5 ml x kg(-1) x min(-1) (P = 0.04), maximum ergometric workload changed from 3.8 +/- 0.3 to 4.4 +/- 0.3 W/kg (P = 0.001), and left ventricular mass index increased from 82 +/- 18 to 108 +/- 29 g/m(2) (P = 0.001).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	72-78
11959475-1	2002	In this study, acetylcholinesterase and choline oxidase were co-immobilized on poly(2-hydroxyethyl methacrylate) membranes and the change in oxygen consumption upon aldicarb introduction was measured.	Oxygen	141-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
12067916-7	2002	Thrombin-activated platelets primed neutrophils for enhanced oxygen-free radical release on triggering with formyl-Met-Leu-Phe, reduced by cerivastatin and simvastatin treatment of platelets.	Oxygen	61-67	coagulation factor II, thrombin	Homo sapiens	0-8
12006357-4	2002	Infusion of glucose and insulin significantly amplified and/or prolonged the cardiovascular, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and counterregulatory hormone responses to LPS, whereas the effects on fever, plasma norepinephrine concentrations, and oxygen consumption were unaffected.	Oxygen	283-289	insulin	Homo sapiens	24-31
11937361-6	2002	Inhibitor L- whose stereochemistry belongs to the stereochemical series of substrate binds CPA like substrate does with its carbonyl oxygen coordinating to the active site zinc ion.	Oxygen	133-139	carboxypeptidase A1	Homo sapiens	91-94
12040027-2	2002	cAMP induction of hSP-A2 expression is O2 dependent and mediated by increased phosphorylation, DNA binding, and transcriptional activation of thyroid transcription factor-1 (TTF-1).	Oxygen	39-41	NK2 homeobox 1	Homo sapiens	174-179
12072866-5	2002	Fasting insulin levels correlated with sleep variables, including log transformed RDI (log(10)RDI) (P =.01), desaturation events (P =.05), arousal index (P =.01), and sleep-time with oxygen saturation in arterial blood &lt;90% (P =.03) (adjusted r (2) = 0.21, F = 3.9, P =.005), but not with age, or BMI Z score.	Oxygen	183-189	insulin	Homo sapiens	8-15
12532179-5	2002	After activation, these cells secrete inflammatory mediators and reactive oxygen species, which can aggravate the aggregation of amyloid-beta.	Oxygen	74-80	amyloid beta precursor protein	Homo sapiens	129-141
12040027-13	2002	This provides intriguing evidence that permissive effects of O2/reactive oxygen species on cAMP regulation of SP-A expression may be mediated by cooperative interactions of TTF-1 and NF-kappaB at the TBE.	Oxygen	61-63	NK2 homeobox 1	Homo sapiens	173-178
12173346-6	2002	RESULTS: Under aerobic culture conditions (5% CO2 plus 21% O2) HTDEC expressed less Bcl-2 and were more susceptible to IFN-gamma-induced apoptosis with significant reductions in both cell proliferation and capillary tube formation, when compared with normal human macrovascular and microvascular EC.	Oxygen	47-49	interferon gamma	Homo sapiens	119-128
11893755-4	2002	In contrast to the very high oxygen affinities displayed by most hexacoordinate hemoglobins, the biophysical characteristics of histoglobin indicate that it could facilitate oxygen transport.	Oxygen	174-180	cytoglobin	Homo sapiens	128-139
12138409-1	2002	Erythropoietin, in its standard role for the treatment of anemia, is often mechanistically regarded simply as increasing blood oxygen-carrying capacity and hence decreasing tumor hypoxia.	Oxygen	127-133	erythropoietin	Homo sapiens	0-14
12036196-9	2002	The frequencies of IL-6 gene genotypes in hemodialysis patients were 16.4% for OO, 52.1% for AO and 31.5% for AA.	Oxygen	79-81	interleukin 6	Homo sapiens	19-23
12011461-1	2002	Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels.	Oxygen	204-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-122
11982365-3	2002	The method of calculation is based on the use of dimethyl phosphate as a reference state for evaluating relative pK(a) values, and on the optimization of the oxygen and acidic hydrogen van der Waals radii to give reasonable pK(1)(a), pK(2)(a), and pK(3)(a) for phosphoric acid in solution.	Oxygen	158-164	pyruvate kinase L/R	Homo sapiens	224-229
11978130-14	2002	Dimer 1 and MeReO(mtp)PPh(3) both catalyze oxygen atom transfer: PicO + PPh(3) --&gt; Pic + Ph(3)PO.	Oxygen	43-49	caveolin 1	Homo sapiens	22-28
11976274-6	2002	Allopurinol, deferoxamine and the combination of superoxide dismutase plus catalase inhibited the contractions to oxygen-derived free radicals but did not significantly affect those to acetylcholine.	Oxygen	114-120	catalase	Rattus norvegicus	75-83
11980636-9	2002	We conclude that geldanamycin induces reduction of HIF-1alpha levels and its downstream transcriptional activity by accelerating protein degradation independent of O2 tension.	Oxygen	164-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
12062197-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
12062197-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
12062197-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.	Oxygen	157-163	erythropoietin	Homo sapiens	180-194
12062197-1	2002	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.	Oxygen	157-163	vascular endothelial growth factor A	Homo sapiens	196-230
11923216-3	2002	To test to what extent hypoxia may contribute to early graft loss, we analyzed the occurrence of apoptotic events and the expression of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor consisting of an oxygen-dependent alpha subunit and a constitutive beta subunit.	Oxygen	226-232	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-162
12012076-8	2002	The average rates of oxygen consumption over the entire immersion period were lower ( P=0.002) during M [0.93 (0.20) l x min(-1)] compared to H [1.05 (0.21) l x min(-1)), and while these rates did not change during the last 90 min of immersion, there was an increase in fat oxidation.	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	121-127
11923216-3	2002	To test to what extent hypoxia may contribute to early graft loss, we analyzed the occurrence of apoptotic events and the expression of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor consisting of an oxygen-dependent alpha subunit and a constitutive beta subunit.	Oxygen	226-232	hypoxia inducible factor 1 subunit alpha	Homo sapiens	164-169
12064001-4	2002	However, little is known about the effects of somatostatin on the pancreatic tissue oxygen pressure and acinar cell injury during acute pancreatitis.	Oxygen	84-90	somatostatin	Rattus norvegicus	46-58
12076076-1	2002	The goal of this study was to determine the effect of two somatostatin analogs, Woc4D and octreotide, on oxygen induced retinopathy in the mouse.	Oxygen	105-111	somatostatin	Mus musculus	58-70
12064001-5	2002	The aim was to evaluate somatostatin by measuring its effect on the pancreatic tissue oxygen pressure and acinar injury in acute pancreatitis.	Oxygen	86-92	somatostatin	Rattus norvegicus	24-36
11940656-3	2002	Hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of HIF-1 alpha regulates its interaction with the von Hippel-Lindau protein (VHL) that targets HIF-1 alpha for ubiquitination and proteasomal degradation.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-103
12007957-2	2002	METHODS AND MATERIALS: Hemoglobin affinity is expressed in terms of P(50), the partial pressure of oxygen (Po(2)) at half saturation.	Oxygen	99-105	nuclear factor kappa B subunit 1	Homo sapiens	68-73
12007957-3	2002	Effects of changing P(50) on arterial Po(2) are predicted using an effective vessel approach to describe diffusive oxygen transport in the lungs, assuming fixed systemic oxygen demand and fixed blood flow rate.	Oxygen	115-121	nuclear factor kappa B subunit 1	Homo sapiens	20-25
12007957-3	2002	Effects of changing P(50) on arterial Po(2) are predicted using an effective vessel approach to describe diffusive oxygen transport in the lungs, assuming fixed systemic oxygen demand and fixed blood flow rate.	Oxygen	170-176	nuclear factor kappa B subunit 1	Homo sapiens	20-25
12071050-1	2002	Myeloperoxidase plays the key role in antimicrobial oxygen-dependent activity of neutrophils.	Oxygen	52-58	myeloperoxidase	Homo sapiens	0-15
11940656-3	2002	Hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of HIF-1 alpha regulates its interaction with the von Hippel-Lindau protein (VHL) that targets HIF-1 alpha for ubiquitination and proteasomal degradation.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	184-195
12022758-3	2002	We hypothesized that LPS priming leads to an exacerbation in the impaired oxygen delivery in response to intraportal infusion of ET-1.	Oxygen	74-80	endothelin 1	Rattus norvegicus	129-133
12022758-12	2002	In the whole liver, ET-1 suppressed oxygen consumption, and this response was potentiated by LPS pretreatment.	Oxygen	36-42	endothelin 1	Rattus norvegicus	20-24
12022758-0	2002	Endothelin 1 impairs oxygen delivery in livers from LPS-primed animals.	Oxygen	21-27	endothelin 1	Rattus norvegicus	0-12
12022758-13	2002	We propose that ET-1 impairs oxygen delivery in the liver during endotoxemia, resulting in areas of focal hypoxia.	Oxygen	29-35	endothelin 1	Rattus norvegicus	16-20
11859074-1	2002	The serine/threonine kinase Akt/PKB and the oxygen-responsive transcription factor HIF-1 share the ability to induce such processes as angiogenesis, glucose uptake, and glycolysis.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-88
12051835-0	2002	Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron.	Oxygen	47-53	Fet4p	Saccharomyces cerevisiae S288C	39-43
11973583-0	2002	[Protective effect of low concentration endothelin-1 on the reactive oxygen-induced inhibition of pulmonary surfactant lipid synthesis].	Oxygen	69-75	endothelin 1	Homo sapiens	40-52
11973583-1	2002	The effects of endothelin-1 (ET-1) at low concentration (1-100 pmol/L) on the reactive oxygen-induced inhibition of both pulmonary surfactant (PS) lipid synthesis and the activity of CTP: phosphorylcholine cytidylyltransferase (CCT), a rate-limiting enzyme in biosynthesis of phosphoatidylcholine (PC), were studied in cultured lung explants without serum.	Oxygen	87-93	endothelin 1	Homo sapiens	15-27
11973583-1	2002	The effects of endothelin-1 (ET-1) at low concentration (1-100 pmol/L) on the reactive oxygen-induced inhibition of both pulmonary surfactant (PS) lipid synthesis and the activity of CTP: phosphorylcholine cytidylyltransferase (CCT), a rate-limiting enzyme in biosynthesis of phosphoatidylcholine (PC), were studied in cultured lung explants without serum.	Oxygen	87-93	endothelin 1	Homo sapiens	29-33
11973583-3	2002	ET-1 reduced both the reactive oxygen-induced decrease in (3)H-choline incorporation and the increase in malondialdehyde (MDA) content of lung tissues, but did not change the levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the total antioxidant capability in the lung explants.	Oxygen	31-37	endothelin 1	Homo sapiens	0-4
11973583-3	2002	ET-1 reduced both the reactive oxygen-induced decrease in (3)H-choline incorporation and the increase in malondialdehyde (MDA) content of lung tissues, but did not change the levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the total antioxidant capability in the lung explants.	Oxygen	31-37	catalase	Homo sapiens	233-241
11973583-3	2002	ET-1 reduced both the reactive oxygen-induced decrease in (3)H-choline incorporation and the increase in malondialdehyde (MDA) content of lung tissues, but did not change the levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the total antioxidant capability in the lung explants.	Oxygen	31-37	catalase	Homo sapiens	243-246
12051835-3	2002	The oxygen regulation of FET4 was found to involve the Rox1p transcriptional repressor.	Oxygen	4-10	Fet4p	Saccharomyces cerevisiae S288C	25-29
12051835-3	2002	The oxygen regulation of FET4 was found to involve the Rox1p transcriptional repressor.	Oxygen	4-10	Rox1p	Saccharomyces cerevisiae S288C	55-60
12051835-10	2002	We found that FET4 contains a complex promoter regulated both by oxygen and iron status.	Oxygen	65-71	Fet4p	Saccharomyces cerevisiae S288C	14-18
12054621-2	2002	Under normal cellular oxygen conditions protein levels of the alpha subunit (HIF-1 alpha) are kept low due to massive ubiquitination and subsequent proteosomal degradation.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-88
12054621-8	2002	Taken together these results strongly indicate that the dietary flavonoid quercetin regulates HIF-1 function at normal oxygen concentrations.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-99
12051835-15	2002	Fet4p is not the only metal transporter that is negatively regulated by oxygen; we find that Rox1p also represses S. cerevisiae SMF3, proposed to function in vacuolar iron transport.	Oxygen	72-78	Fet4p	Saccharomyces cerevisiae S288C	0-5
11959977-1	2002	The cellular response to low tissue oxygen concentrations is mediated by the hypoxia-inducible transcription factor HIF-1.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-121
11948665-2	2002	Using an aggregate culture system derived from the rat fetal cortex, we defined the effects of oxygen and glucose deprivation on NPY expression, using BDNF-induced production of NPY as a functional criterion.	Oxygen	95-101	neuropeptide Y	Rattus norvegicus	129-132
11853865-0	2002	Exogenous endothelin-1 improves microvascular oxygen balance during focal cerebral ischemia in the rat.	Oxygen	46-52	endothelin 1	Rattus norvegicus	10-22
11853865-1	2002	We tested the hypothesis that endothelin-1 (ET-1), a cerebrovasoconstrictive peptide, would alter microvascular oxygen balance during focal cerebral ischemia.	Oxygen	112-118	endothelin 1	Rattus norvegicus	30-42
11948665-3	2002	NPY neurons exhibited a differential susceptibility to oxygen and glucose deprivation.	Oxygen	55-61	neuropeptide Y	Rattus norvegicus	0-3
11948665-5	2002	One-hour exposure to N+Glu- led to a transient inhibition ( approximately 50%) of NPY production manifesting within 24 hr and recovering by 5 days thereafter, a 2-hr exposure to N+Glu- led to a sustained inhibition (50-75%) manifesting 1-5 days thereafter, and a 4-hr exposure to N+Glu- led to a total irreversible suppression of BDNF-induced production of NPY manifesting within 24 hr and lasting 8 days after re-supply of oxygen and glucose.	Oxygen	424-430	neuropeptide Y	Rattus norvegicus	82-85
12023860-2	2002	The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates for the respiratory chain (succinate) and cytochrome c oxidase [N,N,N,N",N"-tetramethyl-p-phenylenediamine dihydrochloride (TMPD)+ascorbate] respectively at 30 degrees C and with maximum ADP stimulation (State 3).	Oxygen	75-81	cytochrome c, somatic	Homo sapiens	218-230
11993874-4	2002	Interaction of As(III) and As(V) with the sulfide surfaces shows primary coordination to four oxygens (As-O: 1.69-1.76 A) with further sulfur (approximately 3.1 A) and iron (3.4-3.5 A) shells suggesting outer sphere complexation.	Oxygen	94-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-32
11993874-2	2002	Arsenic species retain original oxidation states and occupy similar environments on the oxyhydroxide substrates, with first-shell coordination to four oxygens at 1.78 A for As(III) and 1.69 A for As(V).	Oxygen	151-158	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	196-201
12023860-2	2002	The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates for the respiratory chain (succinate) and cytochrome c oxidase [N,N,N,N",N"-tetramethyl-p-phenylenediamine dihydrochloride (TMPD)+ascorbate] respectively at 30 degrees C and with maximum ADP stimulation (State 3).	Oxygen	155-159	cytochrome c, somatic	Homo sapiens	218-230
12023860-8	2002	The flux control coefficient of cytochrome c oxidase, therefore, increases as a function of substrate limitation of oxygen and cytochrome c, which suggests a direct functional role for the apparent excess capacity of cytochrome c oxidase in hypoxia and under conditions of intracellular accumulation of cytochrome c after its release from mitochondria.	Oxygen	116-122	cytochrome c, somatic	Homo sapiens	32-44
11896013-1	2002	Recent studies have demonstrated that oxygen-sensitive type I cells in the carotid body express the gap junction-forming protein connexin43 (Cx43).	Oxygen	38-44	gap junction protein, alpha 1	Rattus norvegicus	129-139
12086861-3	2002	We demonstrate that competitive inhibition of the VHL substrate recognition site with a peptide derived from the oxygen degradation domain of HIF1alpha recapitulates the tumorigenic phenotype of VHL-deficient tumor cells.	Oxygen	113-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-151
11940763-10	2002	The effects of dopexamine on mu-Hbo2 as well as on cardiac output and oxygen delivery were prevented by selective beta2-adrenoceptor-blockade.	Oxygen	70-76	beta-2 adrenergic receptor	Canis lupus familiaris	114-132
11896013-1	2002	Recent studies have demonstrated that oxygen-sensitive type I cells in the carotid body express the gap junction-forming protein connexin43 (Cx43).	Oxygen	38-44	gap junction protein, alpha 1	Rattus norvegicus	141-145
11920680-0	2002	Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1.	Oxygen	4-10	transforming growth factor beta 1	Homo sapiens	96-105
11920680-2	2002	We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming growth factor-beta1 (TGF-beta1) in human dermal fibroblasts.	Oxygen	42-44	transforming growth factor beta 1	Homo sapiens	179-211
11978059-5	2002	Hypoxia Inducible Factor 1(HIF-1) is a transcription factor which activates gene transcription in response to varying oxygen concentration of cells.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-32
11920680-2	2002	We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming growth factor-beta1 (TGF-beta1) in human dermal fibroblasts.	Oxygen	42-44	transforming growth factor beta 1	Homo sapiens	213-222
11932561-6	2002	In contrast to CON, GH treatment improved absolute .VO(2peak) (+19%, P &lt; 0.01), peak ventilation (+14%, P &lt; 0.01), and peak oxygen pulse (+18%, P &lt; 0.01).	Oxygen	130-136	growth hormone 1	Homo sapiens	20-22
11932581-4	2002	During the descent, oxygen uptake and heart rate during the last 30 s of the climb were 17.0 +/- 3.8 mL.kg(-1).min(-1) and 107 +/- 18 beats.min(-1), respectively.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	140-146
12455733-7	2002	A rate constant per unit O2 concentration of 9.40E-10 ppm(-2) min(-1) for humidified gas was significantly higher than 8.27E-10 ppm(-2) min(-1) for "dry" gas (P = 0.008) at 22 degrees C. Rise in NO2 predicted from the "wet" rate constant achieved 3ppm in 65 seconds with 40 ppm NO in 100% oxygen and 107 sec.	Oxygen	25-27	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
12455733-7	2002	A rate constant per unit O2 concentration of 9.40E-10 ppm(-2) min(-1) for humidified gas was significantly higher than 8.27E-10 ppm(-2) min(-1) for "dry" gas (P = 0.008) at 22 degrees C. Rise in NO2 predicted from the "wet" rate constant achieved 3ppm in 65 seconds with 40 ppm NO in 100% oxygen and 107 sec.	Oxygen	25-27	CD59 molecule (CD59 blood group)	Homo sapiens	136-142
12455733-7	2002	A rate constant per unit O2 concentration of 9.40E-10 ppm(-2) min(-1) for humidified gas was significantly higher than 8.27E-10 ppm(-2) min(-1) for "dry" gas (P = 0.008) at 22 degrees C. Rise in NO2 predicted from the "wet" rate constant achieved 3ppm in 65 seconds with 40 ppm NO in 100% oxygen and 107 sec.	Oxygen	289-295	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
11978547-5	2002	Reduced oxygen tension has been shown to increase VEGF production by induction of the transcription factor hypoxia inducible factor 1 alpha (HIF-1alpha).	Oxygen	8-14	vascular endothelial growth factor A	Homo sapiens	50-54
11978547-5	2002	Reduced oxygen tension has been shown to increase VEGF production by induction of the transcription factor hypoxia inducible factor 1 alpha (HIF-1alpha).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-139
11978547-5	2002	Reduced oxygen tension has been shown to increase VEGF production by induction of the transcription factor hypoxia inducible factor 1 alpha (HIF-1alpha).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
11978059-7	2002	Using villous explants, we have demonstrated that the oxygen-regulated events of early trophoblast differentiation are in part mediated by TGFbeta(3), an inhibitor of trophoblast differentiation, via HIF-1alpha.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	200-210
11891305-2	2002	Catalase, which is involved in the degradation of H(2)O(2) into water and oxygen, is the major H(2)O(2)-scavenging enzyme in all aerobic organisms.	Oxygen	74-80	catalase	Homo sapiens	0-8
12014678-7	2002	CONCLUSION: Tumour-secreted factors have a greater inhibitory action than reduced oxygen tension on HUVECs adhesion molecule expression induced by TNFalpha.	Oxygen	82-88	tumor necrosis factor	Homo sapiens	147-155
11779866-1	2002	Hypoxia-inducible factor (HIF)-1alpha is the oxygen-sensitive subunit of HIF-1, a transcriptional master regulator of oxygen homeostasis.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
11779866-1	2002	Hypoxia-inducible factor (HIF)-1alpha is the oxygen-sensitive subunit of HIF-1, a transcriptional master regulator of oxygen homeostasis.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-78
11779866-1	2002	Hypoxia-inducible factor (HIF)-1alpha is the oxygen-sensitive subunit of HIF-1, a transcriptional master regulator of oxygen homeostasis.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
11779866-1	2002	Hypoxia-inducible factor (HIF)-1alpha is the oxygen-sensitive subunit of HIF-1, a transcriptional master regulator of oxygen homeostasis.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-78
11779866-2	2002	Oxygen-dependent prolyl hydroxylation targets HIF-1alpha for ubiquitinylation and proteasomal degradation.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
11882291-4	2002	The effect of SOD1 can also be modulated by cellular oxygen tension.	Oxygen	53-59	superoxide dismutase 1, soluble	Mus musculus	14-18
11861350-7	2002	RESULTS: The measured inspired O(2) concentration was higher in the OA at 2 (26.3 +/- 2.5 vs 23.3 +/- 0.5, P &lt;0.01) and 6 L x min(-1) (33.5 +/- 3.3 vs 28.8 +/- 1.2, P &lt;0.01) flow rates.	Oxygen	31-35	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
11934308-7	2002	The model predicts a sixteen-fold increase in the levels of nerve growth factor by dropping the porosity from 95 to 55% but only at the expense of reducing the oxygen concentration.	Oxygen	160-166	nerve growth factor	Homo sapiens	60-79
11861267-3	2002	Several earlier studies indicated that the regulation of the ventilatory response and erythropoietin (EPO) production by the respective oxygen sensors involves redox-sensitive signaling pathways, which are triggered by the O(2)-dependent production of reactive oxygen species.	Oxygen	136-142	erythropoietin	Homo sapiens	86-100
11861267-3	2002	Several earlier studies indicated that the regulation of the ventilatory response and erythropoietin (EPO) production by the respective oxygen sensors involves redox-sensitive signaling pathways, which are triggered by the O(2)-dependent production of reactive oxygen species.	Oxygen	136-142	erythropoietin	Homo sapiens	102-105
11861267-3	2002	Several earlier studies indicated that the regulation of the ventilatory response and erythropoietin (EPO) production by the respective oxygen sensors involves redox-sensitive signaling pathways, which are triggered by the O(2)-dependent production of reactive oxygen species.	Oxygen	223-227	erythropoietin	Homo sapiens	86-100
11861267-3	2002	Several earlier studies indicated that the regulation of the ventilatory response and erythropoietin (EPO) production by the respective oxygen sensors involves redox-sensitive signaling pathways, which are triggered by the O(2)-dependent production of reactive oxygen species.	Oxygen	223-227	erythropoietin	Homo sapiens	102-105
11885409-5	2002	In response to serious infection, a procoagulant process is activated leading to thrombin and fibrin deposition in small vessels that results in decreased blood flow, decreased oxygen delivery, and organ failure.	Oxygen	177-183	coagulation factor II, thrombin	Homo sapiens	81-89
11865061-2	2002	However, cellular exposure to hypoxia does not induce any detectable level of DNA lesions compared to ionizing radiation, and the oxygen dependency of p53 protein accumulation differs from that of HIF-1, the hypoxia-inducible transcription factor.	Oxygen	130-136	tumor protein p53	Homo sapiens	151-154
11865075-0	2002	Erythropoietin, tumours and the von Hippel-Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing.	Oxygen	112-118	erythropoietin	Homo sapiens	0-14
11855980-3	2002	An ATP binding site model, derived by homology from the FGFR-1 tyrosine kinase crystal structure suggesting hydrogen bonds of one indole NH and the methanone oxygen with the backbone carbonyl and amide, respectively, of Cys684, explains why only one indole moiety is open for substitution and locates groups in the 5- or 6-position outside the pocket.	Oxygen	158-164	fibroblast growth factor receptor 1	Homo sapiens	56-62
11896689-9	2002	In the present paper, we have computationally validated this hypothesis using Langevin dynamics methods to determine the collision frequency of the Met(35) thioether sulfur and the oxygen atoms of several peptide bonds in the betaAP sequence.	Oxygen	181-187	amyloid beta precursor protein	Homo sapiens	226-232
12171246-4	2002	In addition, O2-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with the intracellular redox state, such that modulating redox equilibrium affects their expression/activation.	Oxygen	13-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
11856960-1	2002	The renal medulla contains more mRNA of the inducible isoform of nitric oxide synthase (iNOS) than the cortex, which may be important in preventing ischaemic injury, since blood flow and tissue oxygen tension are normally low in this region.	Oxygen	194-200	nitric oxide synthase 2	Rattus norvegicus	88-92
12048813-2	2002	The results showed that 1.33 x 10(3) Pa CS2 could act with O2 or H2O in the atmosphere (25 degrees C, 10(5) Pa) under electric discharge conditions (V = 3000 V), and COS was produced as well as other species such as CO, CO2, SO2 and so on.	Oxygen	59-61	chorionic somatomammotropin hormone 2	Homo sapiens	40-43
11874235-4	2002	Incubation with 3-morpholinosydnonimine (SIN-1; 0.25-1 mM), an NO* and O2- donor that leads to PN release, also reduced both hOB proliferation and differentiation.	Oxygen	71-73	MAPK associated protein 1	Homo sapiens	41-46
11910013-1	2002	Crd1 (Copper response defect 1), which is required for the maintenance of photosystem I and its associated light-harvesting complexes in copper-deficient (-Cu) and oxygen-deficient (-O(2)) Chlamydomonas reinhardtii cells, is localized to the thylakoid membrane.	Oxygen	164-170	uncharacterized protein	Chlamydomonas reinhardtii	0-4
11910013-1	2002	Crd1 (Copper response defect 1), which is required for the maintenance of photosystem I and its associated light-harvesting complexes in copper-deficient (-Cu) and oxygen-deficient (-O(2)) Chlamydomonas reinhardtii cells, is localized to the thylakoid membrane.	Oxygen	164-170	uncharacterized protein	Chlamydomonas reinhardtii	6-30
11851418-6	2002	Incubation of pinacidil with CYP3A4 in the presence of (18)O(2) or H(2)(18)O showed that the amide carbonyl oxygen derived exclusively from molecular oxygen.	Oxygen	108-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
11851418-6	2002	Incubation of pinacidil with CYP3A4 in the presence of (18)O(2) or H(2)(18)O showed that the amide carbonyl oxygen derived exclusively from molecular oxygen.	Oxygen	150-156	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
11835502-0	2002	The leghemoglobin proximal heme pocket directs oxygen dissociation and stabilizes bound heme.	Oxygen	47-53	leghemoglobin A	Glycine max	4-17
11835502-3	2002	Removal of the constraint provided by covalent attachment of the proximal histidine to the F-helices of these proteins decreases oxygen affinity in Lba and increases oxygen affinity in Mb, mainly because of changes in oxygen dissociation rate constants.	Oxygen	129-135	leghemoglobin A	Glycine max	148-151
11792654-0	2002	Angiotensin II regulates oxygen consumption.	Oxygen	25-31	angiotensinogen	Rattus norvegicus	0-14
11792654-3	2002	Acute ANG II administration decreased oxygen consumption.	Oxygen	38-44	angiotensinogen	Rattus norvegicus	6-12
11792654-5	2002	Oxygen consumption was transiently decreased on day 1 of ANG II infusion; however, body weight and food intake were reduced for 14 days.	Oxygen	0-6	angiotensinogen	Rattus norvegicus	57-63
11792654-10	2002	However, losartan only partially prevented ANG II reductions in oxygen consumption.	Oxygen	64-70	angiotensinogen	Rattus norvegicus	43-49
11792654-11	2002	These results demonstrate that ANG II transiently decreases oxygen consumption through mechanisms unrelated to food intake.	Oxygen	60-66	angiotensinogen	Rattus norvegicus	31-37
11818393-2	2002	The goal of this study was to examine the immunohistochemical localization and relative levels of VEGF receptor-2 (KDR) in canine retina during postnatal vasculogenesis and during angiogenesis in oxygen-induced retinopathy (OIR) and to investigate the effects of neutralizing KDR on these processes.	Oxygen	196-202	kinase insert domain receptor	Canis lupus familiaris	115-118
11845881-8	2002	In group 1, preoperative IL-6 levels inversely correlated with preoperative oxygen saturation (Spearman correlation coefficient, -0.74, p &lt; 0.02).	Oxygen	76-82	interleukin 6	Homo sapiens	25-29
11796494-1	2002	IGF-I is known to stimulate the expression of oxygen- and nutrient-sensitive genes in several cell types.	Oxygen	46-52	insulin like growth factor 1	Homo sapiens	0-5
11821262-2	2002	The heterodimeric hypoxia-inducible factor (HIF) complex is critical in oxygen homeostasis via increased stability of HIF-1alpha/2alpha monomers, and these act as markers of hypoxia.	Oxygen	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
11818393-10	2002	In oxygen-treated animals, anti-KDR significantly inhibited revascularization of the retina (P = 0.005) and formation of intravitreal neovascularization compared with control IgG pellet eyes (P &lt; 0.04).	Oxygen	3-9	kinase insert domain receptor	Canis lupus familiaris	32-35
11818396-4	2002	A window of susceptibility to oxygen-induced vaso-obliteration was defined by comparing the extent of retinal vaso-obliteration resulting from 2 days of hyperoxia beginning on P7, P9, P11, P13, or P15.	Oxygen	30-36	SUB1 homolog, transcriptional regulator	Mus musculus	197-200
11719508-2	2002	We have asked whether also the vascular endothelial growth factor (VEGF) utilizes ROS as messenger intermediates downstream of the VEGF receptor-2 (VEGFR-2)/KDR receptor given that the proliferation of endothelial cells during neoangiogenesis is physiologically regulated by oxygen and likely by its derivative species.	Oxygen	275-281	vascular endothelial growth factor A	Homo sapiens	31-65
11719508-2	2002	We have asked whether also the vascular endothelial growth factor (VEGF) utilizes ROS as messenger intermediates downstream of the VEGF receptor-2 (VEGFR-2)/KDR receptor given that the proliferation of endothelial cells during neoangiogenesis is physiologically regulated by oxygen and likely by its derivative species.	Oxygen	275-281	vascular endothelial growth factor A	Homo sapiens	67-71
11818396-5	2002	RESULTS: Oxygen-induced vaso-obliteration of retinal capillaries was limited to the period between birth and P15.	Oxygen	9-15	SUB1 homolog, transcriptional regulator	Mus musculus	109-112
11858955-2	2002	To clarify the involvement of radical oxygen species in the NF-kappaB activation pathway in keratinocytes, we examined the effect of hydrogen peroxide (H(2)O(2)) on the activation of NF-kappaB in cultured normal human epidermal keratinocytes.	Oxygen	38-44	nuclear factor kappa B subunit 1	Homo sapiens	183-192
11858955-6	2002	The involvement of radical oxygen species in the NF-kappaB activation pathway was suggested.	Oxygen	27-33	nuclear factor kappa B subunit 1	Homo sapiens	49-58
11818497-1	2002	The heterodimeric hypoxia-inducible factor (HIF)-1 is a transcriptional master regulator of several genes involved in mammalian oxygen homeostasis, including erythropoietin, vascular endothelial growth factor, and factors involved in glucose transport and metabolism.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
11905995-0	2002	Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival.	Oxygen	60-66	superoxide dismutase 1, soluble	Mus musculus	107-111
11905995-8	2002	These findings suggest a causal relationship between enhanced oxidative stress and mutant SOD1-mediated motor neuron degeneration, considering that enhanced oxygen free radical production results from the SOD1 structural alterations.	Oxygen	157-163	superoxide dismutase 1, soluble	Mus musculus	90-94
11905995-8	2002	These findings suggest a causal relationship between enhanced oxidative stress and mutant SOD1-mediated motor neuron degeneration, considering that enhanced oxygen free radical production results from the SOD1 structural alterations.	Oxygen	157-163	superoxide dismutase 1, soluble	Mus musculus	205-209
11809856-1	2002	NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage.	Oxygen	304-310	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
11793372-3	2002	These then accumulate in the nucleus and bind to short DNA sequences called hypoxia-response elements (HREs) near or in such oxygen-sensitive genes as that encoding the pro-angiogenic factor vascular endothelial growth factor (VEGF).	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	227-231
11883705-8	2002	Hyperpnea with 95% O2-5% CO2, but not with 95% air-5% CO2, gas mixture induced significant increase in t-butyl hydroperoxide-initiated CL counts, which were inhibited by DMTU, catalase, or SOD in vitro.	Oxygen	19-21	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	189-192
11818497-1	2002	The heterodimeric hypoxia-inducible factor (HIF)-1 is a transcriptional master regulator of several genes involved in mammalian oxygen homeostasis, including erythropoietin, vascular endothelial growth factor, and factors involved in glucose transport and metabolism.	Oxygen	128-134	erythropoietin	Homo sapiens	158-172
11907823-2	2002	The aim of the present study was to examine the hypothesis that up-regulation of both ETA receptor and endogenous ET-1 expression in CB chemoreceptors enhances the response of intracellular Ca2+ to ET-1 following adaptation to chronic hypoxia (10% inspired O2 for 3-4 weeks).	Oxygen	257-259	endothelin 1	Rattus norvegicus	114-118
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Oxygen	174-180	uncharacterized protein	Chlamydomonas reinhardtii	52-56
11842150-2	2002	This response is physiologically relevant because C. reinhardtii experiences these growth conditions routinely, and furthermore, one of the target genes, Crd1, is functionally required for normal growth under oxygen-depleted conditions.	Oxygen	209-215	uncharacterized protein	Chlamydomonas reinhardtii	154-158
11829530-9	2002	NO and NO-derived oxygen species are suggested to modulate the balance between the activities of kinases and phosphatases, thus changing phosphorylation levels for NF, MAP-2, and, possibly, other proteins in neurons and adjacent cell elements.	Oxygen	18-24	microtubule-associated protein 2	Mus musculus	168-173
11823643-1	2002	The hypoxia-inducible factors (HIFs) 1alpha and 2alpha are key mammalian transcription factors that exhibit dramatic increases in both protein stability and intrinsic transcriptional potency during low-oxygen stress.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-54
11841888-10	2002	Treatment groups A-2 and B-2 had total body surface cooling during HS to rectal temperature 32 degrees C and were breathing 100% O(2).	Oxygen	129-133	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	17-28
11833862-2	2002	Vascular endothelial growth factor (VEGF) has detectable levels in the circulation and its expression is highly regulated by oxygen tension.	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	0-34
11969369-3	2002	HIF is primarily regulated through oxygen-dependent proteasomal destruction of the regulatory subunit, HIF-1 alpha or HIF-2 alpha.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-114
11896938-12	2002	The formyl-methionyl-leucyl-phenylalanine (fMLP)-induced proapoptotic reactive oxygen intermediates (ROI) production was significantly higher in DM1 patients.	Oxygen	79-85	formyl peptide receptor 1	Homo sapiens	43-47
11833862-2	2002	Vascular endothelial growth factor (VEGF) has detectable levels in the circulation and its expression is highly regulated by oxygen tension.	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	36-40
11833862-14	2002	CONCLUSIONS: We conclude that circulating VEGF levels are frequently elevated in OSA patients, and may play a role in the regulation of tissue oxygen delivery.	Oxygen	143-149	vascular endothelial growth factor A	Homo sapiens	42-46
11803471-2	2002	We demonstrate that manipulation of redox in air, achieved by inhibiting cytochrome oxidase with cyanide, induces HIF-1 mediated transcription in wild-type CHO and HT1080 human tumour cells but not in CHO cells deficient in the oxygen responsive, HIF-1alpha sub-unit of HIF-1.	Oxygen	228-234	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-119
11698397-1	2002	The ability of copper,zinc superoxide dismutase (Cu,Zn-SOD) to catalyze autoxidation of cysteine and other thiols was investigated by measuring thiol loss and oxygen consumption.	Oxygen	159-165	superoxide dismutase 1	Homo sapiens	55-58
11796207-0	2002	Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity.	Oxygen	56-62	superoxide dismutase 2, mitochondrial	Mus musculus	36-40
11796207-1	2002	Induction or overexpression of pulmonary manganese superoxide dismutase (MnSOD) has been shown to protect against oxygen (O2) toxicity.	Oxygen	114-120	superoxide dismutase 2, mitochondrial	Mus musculus	41-71
11796207-1	2002	Induction or overexpression of pulmonary manganese superoxide dismutase (MnSOD) has been shown to protect against oxygen (O2) toxicity.	Oxygen	114-120	superoxide dismutase 2, mitochondrial	Mus musculus	73-78
11796207-1	2002	Induction or overexpression of pulmonary manganese superoxide dismutase (MnSOD) has been shown to protect against oxygen (O2) toxicity.	Oxygen	122-124	superoxide dismutase 2, mitochondrial	Mus musculus	41-71
11796207-1	2002	Induction or overexpression of pulmonary manganese superoxide dismutase (MnSOD) has been shown to protect against oxygen (O2) toxicity.	Oxygen	122-124	superoxide dismutase 2, mitochondrial	Mus musculus	73-78
11796207-6	2002	Mortality of Sod2-/- mice increased from 0% in room air to 18 and 83% in 50 and 80% O2, respectively.	Oxygen	84-86	superoxide dismutase 2, mitochondrial	Mus musculus	13-17
11796207-8	2002	Histopathological analysis revealed abnormalities in saccules of Sod2-/- mice exposed either to room air or to 50% O2 suggestive of delayed postnatal lung development.	Oxygen	115-117	superoxide dismutase 2, mitochondrial	Mus musculus	65-69
11796207-9	2002	In 50% O2, activities of glutamate-cysteine ligase (GCL) (previously known as gamma-glutamylcysteine synthetase, gamma-GCS) and glutathione peroxidase increased in Sod2-/- (35 and 70%, respectively) and Sod2+/- (12 and 70%, respectively) mice, but glutathione levels remained unaltered.	Oxygen	7-9	superoxide dismutase 2, mitochondrial	Mus musculus	164-168
11796207-9	2002	In 50% O2, activities of glutamate-cysteine ligase (GCL) (previously known as gamma-glutamylcysteine synthetase, gamma-GCS) and glutathione peroxidase increased in Sod2-/- (35 and 70%, respectively) and Sod2+/- (12 and 70%, respectively) mice, but glutathione levels remained unaltered.	Oxygen	7-9	superoxide dismutase 2, mitochondrial	Mus musculus	203-207
11886167-2	2002	The expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, has been shown to be greatly stimulated in osteoblasts by hypoxic stimuli such as deprivation of oxygen and treatment with cobalt.	Oxygen	186-192	vascular endothelial growth factor A	Homo sapiens	18-52
11886167-2	2002	The expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, has been shown to be greatly stimulated in osteoblasts by hypoxic stimuli such as deprivation of oxygen and treatment with cobalt.	Oxygen	186-192	vascular endothelial growth factor A	Homo sapiens	54-58
11848304-9	2002	These findings suggest that FTS is useful for the prevention of tacrolimus-induced nephrotoxicity, and that the increase of renal CAT activity in the defense mechanism of FTS might be important for cell protection against active oxygen species.	Oxygen	229-235	catalase	Rattus norvegicus	130-133
11848304-9	2002	These findings suggest that FTS is useful for the prevention of tacrolimus-induced nephrotoxicity, and that the increase of renal CAT activity in the defense mechanism of FTS might be important for cell protection against active oxygen species.	Oxygen	229-235	AKT interacting protein	Rattus norvegicus	171-174
11779139-4	2002	On the contrary, activation by acetylcholine or endothelial nitric oxide synthase (eNOS), which produces NO while consuming oxygen, induces a significant decrease in PO(2), whose amplitude is dependent on the acetylcholine dose, i.e., the eNOS activity level.	Oxygen	124-130	nitric oxide synthase 3	Homo sapiens	48-81
11707426-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11707426-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11707426-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	161-167	vascular endothelial growth factor A	Homo sapiens	187-221
11707426-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	161-167	vascular endothelial growth factor A	Homo sapiens	223-227
11707426-1	2002	Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that controls transcriptional activation of a number of genes responsive to the low cellular oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin, and glycolytic enzymes.	Oxygen	161-167	erythropoietin	Homo sapiens	230-244
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Oxygen	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
12477260-10	2002	Following delivery the Epo levels vary between species, probably related to the oxygen transport capacity of the hemoglobin (Hb) mass.	Oxygen	80-86	erythropoietin	Homo sapiens	23-26
11779732-7	2002	The degree of nocturnal oxygen desaturation in OSA significantly correlated with the VEGF concentrations (r = 0.67, p &lt; 0.01).	Oxygen	24-30	vascular endothelial growth factor A	Homo sapiens	85-89
11779732-8	2002	In conclusion, serum levels of VEGF are elevated in severely hypoxic patients with OSA and are related to the degree of nocturnal oxygen desaturation.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	31-35
12000224-0	2002	Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion.	Oxygen	67-73	catalase	Rattus norvegicus	49-57
12000224-3	2002	We are studying an oxygen-carrying solution with anitoxidant activity formed by cross-linking hemoglobin, superoxide dismutase, and catalase to form PolyHb-SOD-CAT.	Oxygen	19-25	catalase	Rattus norvegicus	132-140
12000224-3	2002	We are studying an oxygen-carrying solution with anitoxidant activity formed by cross-linking hemoglobin, superoxide dismutase, and catalase to form PolyHb-SOD-CAT.	Oxygen	19-25	catalase	Rattus norvegicus	160-163
12000224-6	2002	The results show that the cross-linked PolyHb-SOD-CAT solution, unlike the other solutions, can supply oxygen to ischemic tissues without causing reperfusion injury in the transient global brain ischemia-reperfusion model.	Oxygen	103-109	catalase	Rattus norvegicus	50-53
11786364-1	2002	Catalase was investigated as a possible catalyst of the electrochemical reduction of oxygen on glassy carbon electrodes.	Oxygen	85-91	catalase	Homo sapiens	0-8
11786364-3	2002	When catalase was adsorbed from dimethylsulfoxide on the surface of electrodes that did not undergo any electrochemical pre-treatment (EP), catalase efficiently catalysed oxygen reduction via direct electron transfer from the electrode (Scheme II).	Oxygen	171-177	catalase	Homo sapiens	5-13
11786364-3	2002	When catalase was adsorbed from dimethylsulfoxide on the surface of electrodes that did not undergo any electrochemical pre-treatment (EP), catalase efficiently catalysed oxygen reduction via direct electron transfer from the electrode (Scheme II).	Oxygen	171-177	catalase	Homo sapiens	140-148
12234095-1	2002	The mammalian EGLN family contains three paralagous genes (EGLN1, EGLN2, and EGLN3) encoding prolyl hydroxylase isoforms that mediate the oxygen-dependent targeting of the transcription factor hypoxia inducible factor alpha to the proteosome.	Oxygen	138-144	egl-9 family hypoxia inducible factor 1	Homo sapiens	59-64
12207089-1	2002	The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen.	Oxygen	134-140	erythropoietin	Homo sapiens	59-73
11842416-5	2002	In addition, the chelated species in the 2 : 1 Co(II)/Carnos system is found to bind oxygen to a lesser degree.	Oxygen	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
11842416-6	2002	With respect to the coordination sites, each Co(II) ion of the binuclear dioxygenated complexes is bound to one oxygen atom and four nitrogen atoms: N(pi) and N(tau) of two Carnos molecules, the peptide, and the terminal amino nitrogen atoms.	Oxygen	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Oxygen	159-165	cytochrome c, somatic	Homo sapiens	29-41
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Oxygen	159-165	cytochrome c, somatic	Homo sapiens	133-145
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Oxygen	195-201	cytochrome c, somatic	Homo sapiens	29-41
11751290-1	2002	The redox-driven proton pump cytochrome c oxidase is that enzymatic machinery of the respiratory chain that transfers electrons from cytochrome c to molecular oxygen and thereby splits molecular oxygen to form water.	Oxygen	195-201	cytochrome c, somatic	Homo sapiens	133-145
12207089-1	2002	The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen.	Oxygen	134-140	erythropoietin	Homo sapiens	75-78
11774241-2	2002	Cu/Zn superoxide dismutase (SOD-1) is an important enzyme in cellular oxygen metabolism.	Oxygen	70-76	superoxide dismutase 1, soluble	Mus musculus	28-33
12046692-4	2002	Immunohistochemical studies showed good preservation of the region-specific expression of CYP2EI and CYP3A4 isoenzymes for up to 72 h of incubation in 70% O2.	Oxygen	155-157	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
11774067-6	2002	Percent body fat was negatively associated with ET and relative oxygen uptake (ml x min(-1) x kg(-1)) and was positively related to submaximal heart rate at 6 minutes exercise (HR6).	Oxygen	64-70	CD59 molecule (CD59 blood group)	Homo sapiens	84-90
11823039-9	2002	IL-3 decreased CFC-generation potential at both oxygen concentrations.	Oxygen	48-54	interleukin 3	Mus musculus	0-4
11774067-7	2002	Fat-free mass was positively related to W(total), P(max) and absolute oxygen uptake (ml x min(-1)).	Oxygen	70-76	CD59 molecule (CD59 blood group)	Homo sapiens	90-96
11774067-8	2002	Relative oxygen uptake (ml x min(-1) x kg(-1)) was related to ET.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	29-35
11774067-9	2002	Absolute oxygen uptake (ml x min(-1)) was related to W(total) and P(max).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	29-35
12090329-4	2002	Normalization of hematocrit with EPO increases oxygen supply to the brain tissue with improvement in brain function.	Oxygen	47-53	erythropoietin	Homo sapiens	33-36
14517639-5	2002	The repeated vital capacity breathing technique was used, with 5% sevoflurane in 10 l.min(-1) oxygen.	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	86-92
11813829-7	2002	CONCLUSIONS: These data imply that i) gelsolin depletion contributes to the pathogenesis of oxygen toxicity and ii) repletion of gelsolin can partially abrogate the resultant exudative response.	Oxygen	92-98	gelsolin	Mus musculus	38-46
11739725-10	2002	Proapoptotic Bcl-2 family members and a functional electron transport chain are required to initiate cell death in response to oxygen deprivation.	Oxygen	127-133	B cell leukemia/lymphoma 2	Mus musculus	13-18
11912914-3	2002	Future biochemical assays that measure the reaction of SOR with O2- should take into account the difficulties of assaying O2- directly and the myriad of redox reactions that can take place between components in the assay, for example, direct electron transfer between cytochrome c and Dfx.	Oxygen	64-66	cytochrome c, somatic	Homo sapiens	268-280
12475556-4	2002	In the present study, we have demonstrated using both methods that the stimulation of BV-2 murine microglial cell line by gamma-interferon and lipopolysaccharide leads to the increase of intracellular oxygen concentration and no change in the intracellular nitrogen concentration.	Oxygen	201-207	interferon gamma	Mus musculus	122-138
11739718-1	2002	Under low-oxygen conditions, cells develop an adaptive program that leads to the induction of several genes, which are transcriptionally regulated by hypoxia-inducible factor 1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-176
11812905-4	2002	Studies on the regulation of the erythropoietin gene have provided insights into the common mechanism of oxygen sensing and signal transduction, leading to activation of the hypoxia-inducible transcription factor 1 (HIF-1).	Oxygen	105-111	erythropoietin	Homo sapiens	33-47
11739718-1	2002	Under low-oxygen conditions, cells develop an adaptive program that leads to the induction of several genes, which are transcriptionally regulated by hypoxia-inducible factor 1 (HIF-1).	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	178-183
11739725-0	2002	Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death.	Oxygen	70-76	B cell leukemia/lymphoma 2	Mus musculus	0-5
11984000-0	2002	Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.	Oxygen	9-15	cyclin dependent kinase inhibitor 2A	Mus musculus	66-69
11984000-0	2002	Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.	Oxygen	9-15	cyclin dependent kinase inhibitor 2A	Mus musculus	70-75
12232783-8	2002	These results suggest that under Pl and oxygen stress conditions relatively minor variations in PSEN2 promoter DNA sequence structure can enhance PSEN2 gene expression and that consequently these may play a role in the induction and/or proliferation of a Pl response in AD brain.	Oxygen	40-46	presenilin 2	Homo sapiens	96-101
12232783-8	2002	These results suggest that under Pl and oxygen stress conditions relatively minor variations in PSEN2 promoter DNA sequence structure can enhance PSEN2 gene expression and that consequently these may play a role in the induction and/or proliferation of a Pl response in AD brain.	Oxygen	40-46	presenilin 2	Homo sapiens	146-151
11812905-4	2002	Studies on the regulation of the erythropoietin gene have provided insights into the common mechanism of oxygen sensing and signal transduction, leading to activation of the hypoxia-inducible transcription factor 1 (HIF-1).	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	174-214
11812905-4	2002	Studies on the regulation of the erythropoietin gene have provided insights into the common mechanism of oxygen sensing and signal transduction, leading to activation of the hypoxia-inducible transcription factor 1 (HIF-1).	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-221
11812905-5	2002	Activation of HIF-1 by hypoxia depends on rescue of its alpha-subunit from oxygen-dependent degradation in the proteasome, allowing it to form a heterodimer with HIF-1 beta.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
11812905-13	2002	In the presence of oxygen and iron, it may induce oxidative modifications that target HIF-1 alpha for ubiquitination and degradation.	Oxygen	19-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-97
12435404-9	2002	The hybridization signals suggest that the local concentration of neuroglobin is sufficient for its putative primary function as an oxygen-supplying protein.	Oxygen	132-138	neuroglobin	Rattus norvegicus	66-77
11868390-2	2002	For example, heme (protein) senses oxygen concentration to regulate hypoxia response genes such as erythropoietin, and free heme, a proxidant, controls levels of several oxidative stress response proteins as well as that of a few enzymes in the heme metabolic pathway.	Oxygen	35-41	erythropoietin	Homo sapiens	99-113
12523169-11	2002	The improved hearing found is, most surely, related to better oxygen supply of ciliated cells of internal ear, resulting from improved oxygen supply in peripheral blood and tissues of the body, and may also be related to the centric activity of erythropoietin, as the presence of receptors for EPO was found in the central nervous system (CNS) neurocytes, and it was also proven that EPO is produced in CNS, probably in astrocytes.	Oxygen	62-68	erythropoietin	Homo sapiens	245-259
12523169-11	2002	The improved hearing found is, most surely, related to better oxygen supply of ciliated cells of internal ear, resulting from improved oxygen supply in peripheral blood and tissues of the body, and may also be related to the centric activity of erythropoietin, as the presence of receptors for EPO was found in the central nervous system (CNS) neurocytes, and it was also proven that EPO is produced in CNS, probably in astrocytes.	Oxygen	62-68	erythropoietin	Homo sapiens	294-297
12523169-11	2002	The improved hearing found is, most surely, related to better oxygen supply of ciliated cells of internal ear, resulting from improved oxygen supply in peripheral blood and tissues of the body, and may also be related to the centric activity of erythropoietin, as the presence of receptors for EPO was found in the central nervous system (CNS) neurocytes, and it was also proven that EPO is produced in CNS, probably in astrocytes.	Oxygen	62-68	erythropoietin	Homo sapiens	384-387
12476614-8	2002	VEGF probably functions as a hypoxia-inducible angiogenic factor, and the expression of VEGF is stronger in malignant tumors, which need more oxygen supply to proliferate.	Oxygen	142-148	vascular endothelial growth factor A	Homo sapiens	88-92
11773609-5	2002	These include regulation of vascular tone, monitoring of oxygen tension in the control of ventilation and erythropoietin production, and signal transduction from membrane receptors in various physiological processes.	Oxygen	57-63	erythropoietin	Homo sapiens	106-120
12510782-5	2002	RESULTS: Oxygen flow peaked at 5.74 +/- 0.28 L x min(-1) (mean +/- SD) at 16.9 +/- 1.5 minutes before rapidly falling to zero.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	49-55
12537605-6	2002	In addition, oxygen-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with the intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation).	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
12537605-7	2002	The differential regulation of HIF-1alpha and NF-kappaB in vitro is paralleled by oxygen-sensitive and redox-dependent pathways governing the regulation of these factors during the transition from placental to lung-based respiration ex utero.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
11801349-6	2002	The most appropriate measure of CPR efficiency appears to be the amount of oxygen delivered to the body during CPR.	Oxygen	75-81	cytochrome p450 oxidoreductase	Homo sapiens	32-35
11801349-6	2002	The most appropriate measure of CPR efficiency appears to be the amount of oxygen delivered to the body during CPR.	Oxygen	75-81	cytochrome p450 oxidoreductase	Homo sapiens	111-114
11801349-8	2002	The best oxygen delivery was provided by continuous chest compression in the early stages of CPR.	Oxygen	9-15	cytochrome p450 oxidoreductase	Homo sapiens	93-96
12181720-1	2002	PURPOSE: Our previous studies showed that tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 are induced after hemorrhagic shock and that their induction is attenuated by hyperbaric oxygen treatment.	Oxygen	188-194	tumor necrosis factor	Rattus norvegicus	42-75
12181720-1	2002	PURPOSE: Our previous studies showed that tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 are induced after hemorrhagic shock and that their induction is attenuated by hyperbaric oxygen treatment.	Oxygen	188-194	interleukin 6	Rattus norvegicus	80-98
11755116-2	2001	Oxygen metabolites localized outside PMNL were visualized by isoluminol enhanced chemiluminescence, whereas chemiluminescence, enhanced with luminol and measured in the presence of the extracellular scavengers superoxide dismutase and catalase, was used for the detection of radicals originated intracellularly.	Oxygen	0-6	catalase	Homo sapiens	235-243
11724565-3	2001	The type II tandem G.U pairs have a combination of wobble and bifurcated hydrogen bonds where the uracil 2-carbonyl oxygen is hydrogen-bonded to both G,H1 and G,H2.	Oxygen	116-122	growth hormone 1	Homo sapiens	150-160
11709422-7	2001	Intravenous infusion of the oxygen radical scavenger N-2-mercaptopropionyl glycine (MPG) initiated 15 min before ischemia and maintained throughout reperfusion obviated chemokine induction, but MPG administration after reperfusion had begun had no effect.	Oxygen	28-34	N-methylpurine-DNA glycosylase	Mus musculus	53-82
11927290-1	2002	Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis).	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11927290-1	2002	Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis).	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11813986-2	2001	This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men.	Oxygen	79-81	nuclear factor kappa B subunit 1	Homo sapiens	112-121
11606485-1	2001	The heterodimeric hypoxia-inducible factor (HIF)-1 is a master transcriptional regulator of oxygen homeostasis and a possible target for gene therapy of ischemic disease.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
11606485-2	2001	Although the role of oxygen concentration in HIF-1a protein stabilization is well established, it is less clear whether and how oxygen-regulated mechanisms contribute to HIF-1a protein modifications, nuclear translocation, heterodimerization with the b-subunit, recruitment of cofactors, and gene trans-activation.	Oxygen	128-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	170-176
11829095-9	2001	Respirologists in Canada and the USA increased the resting Sa,O2 by 1-2 L x min(-1) during sleep, while those in Spain used the resting (awake) flow for the night prescription (62%).	Oxygen	62-64	CD59 molecule (CD59 blood group)	Homo sapiens	76-82
11640951-6	2001	A pharmacologically reinforced cAMP signaling in rat glial cell cultures depressed oxygen radical formation in microglia and their release of TNF-alpha and interleukine-1beta, feed-forward signals which mediate oxidative damage and secondary astrocyte activation.	Oxygen	83-89	tumor necrosis factor	Rattus norvegicus	142-151
11775128-7	2001	In multiple regression analyses, lower oxygen reserve was related to higher LVMI(MRI) (beta = -0.44), lower systemic vascular compliance (beta = -0.36), and higher MFVR (beta = -0.52) (adjusted R2 = 0.53, P &lt; .001).	Oxygen	39-45	cell cycle regulator of NHEJ	Homo sapiens	76-85
11800230-5	2001	The spectral changes indicate that the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca- in the malonate chelation mode, where a Ca2+ interacts with two oxygen atoms, one from each of the two COO- groups of a single gamma-carboxyglutamic acid residue.	Oxygen	175-181	bone gamma-carboxyglutamate protein	Homo sapiens	81-92
11726537-1	2001	The key elements of circadian clockwork and oxygen homeostasis are the PAS protein family members PER and CLOCK and hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	44-50	circadian locomotor output cycles kaput	Mus musculus	106-111
11717222-7	2001	Blood level of erythropoietin was related (r = 0.77) to arterial oxygen saturation but not to the levels of progesterone or estradiol.	Oxygen	65-71	erythropoietin	Homo sapiens	15-29
11881132-2	2001	The tissue oxygen pressure required to trigger the Epo gene under physiological conditions is uniquely sited at a restricted area in the kidney termed the critmeter.	Oxygen	11-17	erythropoietin	Homo sapiens	51-54
11881132-3	2001	Angiotensin II (Ang II) increases sodium reabsorption and hence oxygen consumption at any given bloodflow rate; therefore, it may affect the balance of renal oxygen supply vs. demand and hence Epo production.	Oxygen	64-70	angiotensinogen	Homo sapiens	0-14
11881132-3	2001	Angiotensin II (Ang II) increases sodium reabsorption and hence oxygen consumption at any given bloodflow rate; therefore, it may affect the balance of renal oxygen supply vs. demand and hence Epo production.	Oxygen	64-70	angiotensinogen	Homo sapiens	16-22
11881132-3	2001	Angiotensin II (Ang II) increases sodium reabsorption and hence oxygen consumption at any given bloodflow rate; therefore, it may affect the balance of renal oxygen supply vs. demand and hence Epo production.	Oxygen	158-164	angiotensinogen	Homo sapiens	0-14
11881132-3	2001	Angiotensin II (Ang II) increases sodium reabsorption and hence oxygen consumption at any given bloodflow rate; therefore, it may affect the balance of renal oxygen supply vs. demand and hence Epo production.	Oxygen	158-164	angiotensinogen	Homo sapiens	16-22
11709422-7	2001	Intravenous infusion of the oxygen radical scavenger N-2-mercaptopropionyl glycine (MPG) initiated 15 min before ischemia and maintained throughout reperfusion obviated chemokine induction, but MPG administration after reperfusion had begun had no effect.	Oxygen	28-34	N-methylpurine-DNA glycosylase	Mus musculus	84-87
11709422-7	2001	Intravenous infusion of the oxygen radical scavenger N-2-mercaptopropionyl glycine (MPG) initiated 15 min before ischemia and maintained throughout reperfusion obviated chemokine induction, but MPG administration after reperfusion had begun had no effect.	Oxygen	28-34	N-methylpurine-DNA glycosylase	Mus musculus	194-197
11677137-3	2001	The molecular modeling study for CPA(2R,3R)-3 complex suggested that the lone pair electrons on the nitrogen of the aziridine ring in the inhibitor forms a coordinative bond with the active site zinc ion and the proton on the nitrogen is engaged in hydrogen bonding with one of the carboxylate oxygens of Glu-270.	Oxygen	294-301	carboxypeptidase A1	Homo sapiens	33-36
11527963-2	2001	We have previously shown that a mutation in mev-1 causes shortened life span and rapid accumulation of aging markers such as fluorescent materials and protein carbonyls in an oxygen-dependent fashion.	Oxygen	175-181	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	44-49
11698451-6	2001	In the MRL/lpr mice, the catalytic subsets that existed in the initial repertoire were effectively captured by the phosphonyl oxygens in the TSA by interacting with the lysine at H95.	Oxygen	126-133	Fas (TNF receptor superfamily member 6)	Mus musculus	11-14
11527963-4	2001	Here we report important biochemical changes in mev-1 animals that serve to explain their abnormalities under normoxic conditions: (i) an overproduction of superoxide anion from mitochondria; and (ii) a reciprocal reduction in glutathione content even under atmospheric oxygen.	Oxygen	270-276	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	48-53
11820317-3	2001	Hyperbaric oxygen (HBO) inhalation also stimulates intracellular ROS production although the effects of HBO on skeletal muscle SOD, GPx and CAT activity have not been studied.	Oxygen	11-17	catalase	Rattus norvegicus	140-143
11592937-7	2001	In normal dogs, bradykinin (10(-4) M), ramiprilat (10(-4) M), amlodipine (10(-5) M), and SNAP (10(-4) M) significantly reduced O(2) consumption in the renal cortex (-31.8 +/- 0.9, -30.3 +/- 1.1, -30.1 +/- 2.0, -46.9 +/- 1.0%) and renal medulla (-29.7 +/- 2.1, -33.0 +/- 2.7, -30.8 +/- 2.2, -46.8 +/- 1.1%).	Oxygen	127-131	kininogen 1	Canis lupus familiaris	16-26
11598268-6	2001	These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen.	Oxygen	100-106	HIF prolyl hydroxylase	Drosophila melanogaster	29-32
11604545-2	2001	At pH 7.0 and 15 degrees C, the oxygen pressure at half saturation (p50) was measured to be 12.4 +/- 0.2 and 139 +/- 4 torr for hemoglobin gels prepared in the absence and presence of the strong allosteric effectors inositol hexaphosphate and bezafibrate, respectively.	Oxygen	32-38	nuclear factor kappa B subunit 1	Homo sapiens	68-71
11677045-2	2001	Increase in A beta production is followed by chelation of transition metal ions by A beta, accumulation of A beta-metal lipoprotein aggregates, production of reactive oxygen species and neurotoxicity.	Oxygen	167-173	amyloid beta precursor protein	Homo sapiens	12-18
11677045-5	2001	Most importantly, they embrace pathological mechanisms known to develop in aging (which is the major risk factor for AD), such as increased production of reactive oxygen species by mitochondria, that are positioned upstream relative to the generation of A beta.	Oxygen	163-169	amyloid beta precursor protein	Homo sapiens	254-260
11691837-2	2001	The chief mediator of hypoxic response in mammalian tissues is the transcription factor hypoxia-inducible factor 1 (HIF-1), and its oxygen-sensitive component HIF-1alpha.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-114
11691837-2	2001	The chief mediator of hypoxic response in mammalian tissues is the transcription factor hypoxia-inducible factor 1 (HIF-1), and its oxygen-sensitive component HIF-1alpha.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
11719891-3	2001	On the other hand, attempts have been made to improve maximal oxygen uptake by artificial means: blood doping and the misuse of recombinant human erythropoietin have beneficial effects on aerobic exercise capacity.	Oxygen	62-68	erythropoietin	Homo sapiens	146-160
11689745-5	2001	RESULTS: In the training group: a) maximal oxygen uptake (VO2max) increased from 58.1 +/- 4.5 mL x kg(-1) x min(-1) to 64.3 +/- 3.9 mL x kg(-1) x min(-1) (P &lt; 0.01); b) lactate threshold improved from 47.8 +/- 5.3 mL x kg(-1) x min(-1) to 55.4 +/- 4.1 mL x kg(-1) x min(-1) (P &lt; 0.01); c) running economy was also improved by 6.7% (P &lt; 0.05); d) distance covered during a match increased by 20% in the training group (P &lt; 0.01); e) number of sprints increased by 100% (P &lt; 0.01); f) number of involvements with the ball increased by 24% (P &lt; 0.05); g) the average work intensity during a soccer match, measured as percent of maximal heart rate, was enhanced from 82.7 +/- 3.4% to 85.6 +/- 3.1% (P &lt; 0.05); and h) no changes were found in maximal vertical jumping height, strength, speed, kicking velocity, kicking precision, or quality of passes after the training period.	Oxygen	43-49	CD59 molecule (CD59 blood group)	Homo sapiens	108-114
11758334-4	2001	Anesthesia was induced with sevoflurane slowly increased to 5% in nitrous oxide 3 l.min-1 with oxygen 3 l.min-1.	Oxygen	95-101	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
11758334-4	2001	Anesthesia was induced with sevoflurane slowly increased to 5% in nitrous oxide 3 l.min-1 with oxygen 3 l.min-1.	Oxygen	95-101	CD59 molecule (CD59 blood group)	Homo sapiens	106-111
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Oxygen	151-153	nitric oxide synthase 2	Homo sapiens	48-69
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Oxygen	151-153	nitric oxide synthase 2	Homo sapiens	71-75
11678630-3	2001	Endothelium removal and treatment of GA with 17-octadecynoic acid (17-ODYA; suicide substrate inhibitor of CP450 4A enzymes) impaired oxygen-induced constriction of the vessels; treatment of endothelium-denuded GA with 17-ODYA eliminated responses to elevated PO2.	Oxygen	134-140	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-112
11713650-7	2001	Interestingly, HIF-1 activity could be restored fully by point-mutating the ET-1 (but not the Flt-1) HBS, suggesting that the wild-type ET-1 HBS attenuated the full hypoxic response known from other oxygen-regulated genes.	Oxygen	199-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-20
11713650-7	2001	Interestingly, HIF-1 activity could be restored fully by point-mutating the ET-1 (but not the Flt-1) HBS, suggesting that the wild-type ET-1 HBS attenuated the full hypoxic response known from other oxygen-regulated genes.	Oxygen	199-205	endothelin 1	Homo sapiens	136-140
11583958-14	2001	These results suggest that reactive oxygen intermediate generation, after a brief ischemic episode, is capable of inducing MCP-1 expression in venular endothelium through AP-1 and NF-kappaB.	Oxygen	36-42	C-C motif chemokine ligand 2	Canis lupus familiaris	123-128
11641274-1	2001	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11641274-1	2001	Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11641274-2	2001	O(2)-dependent binding of the von Hippel-Lindau (VHL) tumor suppressor protein targets the HIF-1alpha subunit for ubiquitination and proteasomal degradation.	Oxygen	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
11641274-6	2001	Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration.	Oxygen	196-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
11583893-9	2001	Baseline ANP including all patients significantly correlated with PVR, right atrial pressure, cardiac index, RV ejection fraction, mixed venous oxygen saturation and cGMP.	Oxygen	144-150	natriuretic peptide A	Homo sapiens	9-12
11694457-8	2001	Analysis of p21(CIP1), an inhibitor of CDK, revealed an increased expression in O(2)-exposed cells that was no longer observed in cells treated with RA.	Oxygen	80-84	cyclin dependent kinase inhibitor 1A	Homo sapiens	12-15
11694457-8	2001	Analysis of p21(CIP1), an inhibitor of CDK, revealed an increased expression in O(2)-exposed cells that was no longer observed in cells treated with RA.	Oxygen	80-84	cyclin dependent kinase inhibitor 1A	Homo sapiens	16-20
11685376-1	2001	Washed cells of Desulfovibrio vulgaris strain Marburg (DSM 2119) reduced oxygen to water with H(2) as electron donor at a mean rate of 253 nmol O(2) min(-1) (mg protein)(-1).	Oxygen	73-79	CD59 molecule (CD59 blood group)	Homo sapiens	149-155
11585703-1	2001	Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11585703-1	2001	Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation.	Oxygen	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11686499-4	2001	Since COII carries a binding site for cytochrome c in the respiratory chain, and since it is required for the passage of chain electrons to molecular oxygen, driving the production of ATP, we hypothesized that metabolic dysfunction resulting from TBI alters COII gene expression directly, perhaps influencing the synaptic plasticity that occurs during postinjury recovery processes.	Oxygen	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
12060292-3	2001	Excess electrons from the photosynthetic and respiratory electron transport chains can be used for the reduction of oxygen, thus producing superoxide radicals (O2.-); these are subsequently transformed to H2O2 via superoxide dismutase (SOD; EC 1.15.1.1).	Oxygen	160-162	superoxide dismutase 1	Homo sapiens	214-234
11768244-7	2001	After exposure to hypoxia for 21 days (10% O2), Bcl-2 protein expression markedly increased, (44%) in gastrocnemius, (323%) in soleus and (1178%) in heart, with significant differences (p &lt; 0.05 student t-test), reaching a similar threshold of expression in both types of muscles.	Oxygen	43-45	BCL2, apoptosis regulator	Rattus norvegicus	48-53
11887493-4	2001	ET-1 levels were also significantly correlated with arterial oxygen (PaO2) (r = -0.935, p &lt; 0.001) and mean pulmonary arterial pressure (Ppa) (r = 0.657, p &lt; 0.001).	Oxygen	61-67	endothelin 1	Homo sapiens	0-4
12060292-3	2001	Excess electrons from the photosynthetic and respiratory electron transport chains can be used for the reduction of oxygen, thus producing superoxide radicals (O2.-); these are subsequently transformed to H2O2 via superoxide dismutase (SOD; EC 1.15.1.1).	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	214-234
12060292-3	2001	Excess electrons from the photosynthetic and respiratory electron transport chains can be used for the reduction of oxygen, thus producing superoxide radicals (O2.-); these are subsequently transformed to H2O2 via superoxide dismutase (SOD; EC 1.15.1.1).	Oxygen	116-122	superoxide dismutase 1	Homo sapiens	236-239
11579174-13	2001	Muscle V(O2) increased (P &lt; 0.05) by 0.06 +/- 0.03 (12 %) and 0.09 +/- 0.03 l min(-1) (14 %) from the third minute to the end of exercise at 60 and 100 r.p.m., respectively, but there was no difference between the two frequencies.	Oxygen	9-11	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
11828724-0	2001	[The effect of O2 therapy on mixed venous concentration of endothelin-1 in chronic obstructive pulmonary disease].	Oxygen	15-17	endothelin 1	Homo sapiens	59-71
11828724-3	2001	We therefore assessed the correlation of PH and ET-1, and the effect of O2 therapy on the plasma ET-1 concentration.	Oxygen	72-74	endothelin 1	Homo sapiens	97-101
11828724-4	2001	In COPD patients, the plasma ET-1 level in mixed venous blood, but not in arterial blood, was negatively correlated with mixed venous O2 tension and positively correlated with pulmonary vascular resistance.	Oxygen	134-136	endothelin 1	Homo sapiens	29-33
11828724-6	2001	O2 administration significantly suppressed the plasma ET-1 level.	Oxygen	0-2	endothelin 1	Homo sapiens	54-58
11828724-8	2001	and O2 administration decreased the plasma ET-1 level in mixed venous blood.	Oxygen	4-6	endothelin 1	Homo sapiens	43-47
11744946-8	2001	Absolute maximal oxygen uptake increased linearly from 1.2 +/- 0.2 L x min(-1) at age 7-9 years to 2.5 +/- 0.5 L x min(-1) at age 13-15 years.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	71-77
11744946-8	2001	Absolute maximal oxygen uptake increased linearly from 1.2 +/- 0.2 L x min(-1) at age 7-9 years to 2.5 +/- 0.5 L x min(-1) at age 13-15 years.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	115-121
11568365-0	2001	p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.	Oxygen	64-70	tumor protein p53	Homo sapiens	0-3
11568365-0	2001	p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.	Oxygen	64-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	27-30
11568365-0	2001	p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.	Oxygen	64-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-35
11568365-0	2001	p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.	Oxygen	64-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-40
11568365-0	2001	p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.	Oxygen	64-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	tumor protein p53	Homo sapiens	74-77
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	120-123
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	124-128
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	129-133
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-138
11568365-2	2001	Cells respond to oxygen-induced damage by expressing the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), which limits proliferation by blocking entry into S phase.	Oxygen	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-144
11568365-5	2001	Hyperoxia (95% O2, 5% CO2) increased p53 abundance, phosphorylation of p53 on serine 15, and p21 mRNA and protein in parental HCT116 cells that ceased proliferation.	Oxygen	15-17	tumor protein p53	Homo sapiens	37-40
11568365-5	2001	Hyperoxia (95% O2, 5% CO2) increased p53 abundance, phosphorylation of p53 on serine 15, and p21 mRNA and protein in parental HCT116 cells that ceased proliferation.	Oxygen	15-17	tumor protein p53	Homo sapiens	71-74
11568365-8	2001	The observation that p53-dependent induction of p21 prevents exit from G1 and promotes survival during hyperoxia is consistent with the importance of limiting DNA replication during genotoxic stress caused by oxygen exposure.	Oxygen	209-215	tumor protein p53	Homo sapiens	21-24
11568365-8	2001	The observation that p53-dependent induction of p21 prevents exit from G1 and promotes survival during hyperoxia is consistent with the importance of limiting DNA replication during genotoxic stress caused by oxygen exposure.	Oxygen	209-215	cyclin dependent kinase inhibitor 1A	Homo sapiens	48-51
11694184-8	2001	A step change in oxygen tension from 2% to 20% caused cells in the bioreactor to increase 17beta-estradiol secretion and shifted cell cycle from proliferation to differentiation, which were verified with the expression levels of cyclin B1 and p27(kip1).	Oxygen	17-23	zinc ribbon domain containing 2	Homo sapiens	243-246
11563840-3	2001	We previously demonstrated that incubation under reduced oxygen levels increases the in vitro invasiveness of trophoblast and breast carcinoma cells, an effect linked to elevated expression of the cell surface receptor for urokinase-type plasminogen activator (uPAR).	Oxygen	57-63	plasminogen activator, urokinase	Homo sapiens	223-259
11563840-5	2001	Compared to exposure to 20 and 5% oxygen, exposure to 1% oxygen decreased adhesion of these cells to vitronectin and fibronectin, an effect that was reversible by re-exposure to 20% oxygen.	Oxygen	57-63	fibronectin 1	Homo sapiens	117-128
11563840-5	2001	Compared to exposure to 20 and 5% oxygen, exposure to 1% oxygen decreased adhesion of these cells to vitronectin and fibronectin, an effect that was reversible by re-exposure to 20% oxygen.	Oxygen	57-63	fibronectin 1	Homo sapiens	117-128
11562475-1	2001	We have shown previously that at physiologically relevant oxygen tension (pO(2) approximately 10 mmHg), NO S-nitrosylates 1 of approximately 50 free cysteines per ryanodine receptor 1 (RyR1) subunit and transduces a calcium-sensitizing effect on the channel by means of calmodulin (CaM).	Oxygen	58-64	ryanodine receptor 1	Homo sapiens	185-189
11549290-3	2001	Interestingly, while MAPK appears to specifically upregulate the transactivation activity of HIF-1alpha through direct phosphorylation of its regulatory/inhibitory domain, GSK-3, a downstream target of Akt, directly phosphorylates the HIF-1alpha oxygen-dependent degradation domain.	Oxygen	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-103
11549290-3	2001	Interestingly, while MAPK appears to specifically upregulate the transactivation activity of HIF-1alpha through direct phosphorylation of its regulatory/inhibitory domain, GSK-3, a downstream target of Akt, directly phosphorylates the HIF-1alpha oxygen-dependent degradation domain.	Oxygen	246-252	AKT serine/threonine kinase 1	Homo sapiens	202-205
11514273-2	2001	Although HSR did not cause major disturbances of hepatic perfusion per se, the response to ET-1 (0.5 x 10(-9) M) was enhanced, leading to greater increases in portal driving pressure, total portal resistance, and zero-flow pressures and more pronounced decreases in portal flow, sinusoidal diameters, and hepatic oxygen delivery compared with time-matched sham shock controls.	Oxygen	313-319	endothelin 1	Rattus norvegicus	91-95
11514315-2	2001	The decrease in MnSOD activity was associated with increased mitochondrial oxidative damage as demonstrated by a decrease in the activities of iron sulfhydryl proteins sensitive to oxygen stress (aconitase and reduced nicotinamide adenine dinucleotide-oxidoreductase).	Oxygen	181-187	superoxide dismutase 2, mitochondrial	Mus musculus	16-21
12060292-3	2001	Excess electrons from the photosynthetic and respiratory electron transport chains can be used for the reduction of oxygen, thus producing superoxide radicals (O2.-); these are subsequently transformed to H2O2 via superoxide dismutase (SOD; EC 1.15.1.1).	Oxygen	160-162	superoxide dismutase 1	Homo sapiens	236-239
11509536-5	2001	Subjects of different ACE genotypes had similar peak oxygen uptakes and APFT scores, both before and after training.	Oxygen	53-59	angiotensin I converting enzyme	Homo sapiens	22-25
11509278-7	2001	Our additional finding was that there was a negative correlation between IL-8 level and hemoglobin saturation with oxygen in coronary sinus blood 10 min after coronary reperfusion.	Oxygen	115-121	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
11590848-13	2001	Transfusion of packed red blood cells or erythropoietin (before and following the procedure, if needed) may be necessary to increase oxygen content.	Oxygen	133-139	erythropoietin	Homo sapiens	41-55
11489845-10	2001	ARE2 requires the HAP1 transcription factor for optimal expression, and both ARE genes are derepressed in a rox1 (repressor of oxygen) mutant genetic background.	Oxygen	127-133	Rox1p	Saccharomyces cerevisiae S288C	108-112
11514675-3	2001	Oxygen equilibrium-binding studies in solution, which measure the overall oxygen affinity (the p50) and the overall cooperativity (the Hill coefficient) of a hemoglobin solution, show that removing the phenolic hydroxyl group of Tyr35beta results in small decreases in oxygen affinity and cooperativity.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	95-98
11604023-3	2001	Data set 1 contains 176 compounds having one or more nitrogen atoms with some oxygen (log S[mol/L] range is -7.41 to 0.96).	Oxygen	78-84	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	5-10
11517237-8	2001	High oxygen also prevented NO-induced neuronal death, consistent with death being induced by NO inhibition of cytochrome c oxidation in competition with oxygen.	Oxygen	5-11	cytochrome c, somatic	Homo sapiens	110-122
11511254-1	2001	A set of aryl-substituted allylic alcohols rac-2 has been epoxidized by chiral Mn(salen*) complexes 1 as the catalyst and iodosyl benzene (PhIO) as the oxygen source.	Oxygen	152-158	Rac family small GTPase 2	Homo sapiens	43-48
11526493-9	2001	Two amino acid substitutions (Pro582Ser and Ala588Thr) were identified in the oxygen-dependent degradation/pVHL binding domain of HIF-1alpha, however neither substitution was observed exclusively in tumour samples.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
11507045-3	2001	However, the relationship between tissue oxygen partial pressure (pO(2))/pH and VEGF transcription in vivo is not known.	Oxygen	41-47	vascular endothelial growth factor A	Homo sapiens	80-84
11476743-2	2001	In the CPR laboratory simulating adult pigs with ventricular fibrillation or postcountershock pulseless electrical activity, vasopressin improved vital organ blood flow, cerebral oxygen delivery, resuscitability, and neurological recovery better than did epinephrine.	Oxygen	179-185	vasopressin	Sus scrofa	125-136
11506127-2	2001	Halothane is reduced under low oxygen tensions by CYP2A6 and CYP3A4 in human liver microsome to an unstable free radical, and then to the volatile metabolites chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE).	Oxygen	31-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67
11479173-7	2001	The kidney has the unique ability to translate a measure of plasma volume as tissue oxygen pressure required to regulate erythropoietin production.	Oxygen	84-90	erythropoietin	Homo sapiens	121-135
11479173-10	2001	Renal vasculature and nephron segment heterogeneity in sodium reabsorption generate the marginal tissue oxygen pressure required to trigger the production of erythropoietin.	Oxygen	104-110	erythropoietin	Homo sapiens	158-172
11468193-3	2001	In solution studies of HbS by Benesch et al, it was demonstrated that p50, the point at which hemoglobin is half-saturated with oxygen, is proportional to the amount of polymer formed and that it may be used to measure C(SAT).	Oxygen	128-134	nuclear factor kappa B subunit 1	Homo sapiens	70-73
11498006-1	2001	Cytochrome c oxidase is an intricate metalloprotein that transfers electrons from cytochrome c to oxygen in the last step of the mitochondrial respiratory chain.	Oxygen	98-104	cytochrome c, somatic	Homo sapiens	0-12
11498006-1	2001	Cytochrome c oxidase is an intricate metalloprotein that transfers electrons from cytochrome c to oxygen in the last step of the mitochondrial respiratory chain.	Oxygen	98-104	cytochrome c, somatic	Homo sapiens	82-94
11775062-2	2001	Increased production of A beta in a form of lipoprotein antioxidant under the action of increased oxidative stress in aging with subsequent chelation of transition metal ions by A beta, accumulation of toxic A beta-metal lipoprotein complexes, production of reactive oxygen species, and neurotoxicity are reviewed and postulated to form the temporal sequence of events in the development of Alzheimer"s disease (AD).	Oxygen	267-273	amyloid beta precursor protein	Homo sapiens	24-30
11483405-6	2001	Quite similarly, accumulation of HIF-1alpha not only occurs during hypoxia, but also under conditions of NO delivery, thus mimicking a situation of reduced oxygen availability.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
11526436-8	2001	Both TNF-induced necrosis and necrosis induced by anti-Fas in the presence of the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone are prevented by the serine protease inhibitor N-tosyl-L-phenylalanine chloromethylketone and the oxygen radical scavenger butylated hydroxyanisole, while Fas-induced apoptosis is not affected.	Oxygen	252-258	tumor necrosis factor	Mus musculus	5-8
11697581-5	2001	HIF-1 modulates gene activity in response to low O2 tensions in the developing and in the adult brain.	Oxygen	49-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
11665862-3	2001	Because the brain has a high metabolic rate and is sensitive to changes in the supply of glucose and oxygen, we investigated the expression of AMPK in rat embryonic and adult brain and its role in modifying neuronal survival under conditions of cellular stress.	Oxygen	101-107	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	143-147
11447176-5	2001	However, SodC has a lipoprotein binding motif, which suggests that it may be anchored in the membrane to protect M. tuberculosis from reactive oxygen intermediates at the bacterial surface.	Oxygen	143-149	superoxide dismutase 1, soluble	Mus musculus	9-13
11594511-1	2001	Optimal oxygen-dependent antimicrobial activity of circulating polymorphonuclear leukocytes reflects the synergistic effects of the myeloperoxidase (MPO)-hydrogen peroxide-halide system.	Oxygen	8-14	myeloperoxidase	Homo sapiens	132-147
11594511-1	2001	Optimal oxygen-dependent antimicrobial activity of circulating polymorphonuclear leukocytes reflects the synergistic effects of the myeloperoxidase (MPO)-hydrogen peroxide-halide system.	Oxygen	8-14	myeloperoxidase	Homo sapiens	149-152
11516994-0	2001	Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11678584-8	2001	BAT O2 consumption was depressed by NPY treatment (P &lt; 0.001) and increased by NE (P &lt; 0.001).	Oxygen	4-6	neuropeptide Y	Rattus norvegicus	36-39
11678584-9	2001	In euthyroid Sx rats, NPY decreased O2 consumption (P &lt; 0.001).	Oxygen	36-38	neuropeptide Y	Rattus norvegicus	22-25
11678584-11	2001	The results show that NPY blocked the effects of T3 on BAT O2 consumption, and that cold-induced activation of the thermogenic process did not produce measurable changes in hypothalamic NPY.	Oxygen	59-61	neuropeptide Y	Rattus norvegicus	22-25
11516994-1	2001	Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11516994-1	2001	Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11454339-3	2001	The interaction of 2 with the D-fructose transporter GLUT5, was found to be weaker than that of D-fructose, a result that suggests involvement of the ring oxygen atom in the recognition of D-fructose by GLUT5.	Oxygen	155-161	solute carrier family 2 member 5	Homo sapiens	53-58
11442362-7	2001	These studies are then extended to consider the new features present in the binuclear non-heme iron enzymes and applied to understand (1) the mechanism of the two electron/coupled proton transfer to dioxygen binding to a single iron center in hemerythrin and (2) structure/function correlations over the oxygen-activating enzymes stearoyl-ACP Delta9-desaturase, ribonucleotide reductase, and methane monooxygenase.	Oxygen	199-207	fatty acid desaturase 3	Homo sapiens	343-360
11454339-3	2001	The interaction of 2 with the D-fructose transporter GLUT5, was found to be weaker than that of D-fructose, a result that suggests involvement of the ring oxygen atom in the recognition of D-fructose by GLUT5.	Oxygen	155-161	solute carrier family 2 member 5	Homo sapiens	203-208
11431174-7	2001	In addition, dissociation of iron from filtered transferrin, occasioned by a reduction in tubular fluid pH, can promote tubulointerstitial injury through the iron-catalyzed generation of oxygen free radicals.	Oxygen	187-193	transferrin	Homo sapiens	48-59
11440974-3	2001	TNF-alpha caused a dose-dependent increase in reactive oxygen and nitrogen intermediates in CA SMCs (P&lt;0.05).	Oxygen	55-61	tumor necrosis factor	Homo sapiens	0-9
11427068-2	2001	An initial model compound was constructed from a structure obtained by 300-ps molecular dynamics simulation of compound I-formed P-450cam under physiologic conditions, and it consisted of porphine for protoporphyrin IX, S(-)-CH(3) for the side chain of Cys357 of the fifth ligand of heme, a methane molecule for the substrate, a heme iron, and an oxygen atom of the sixth ligand of heme.	Oxygen	347-353	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-121
18968331-3	2001	Phenol was oxidized by tyrosinase and horse-radish peroxidase via catechol to o-quinone in the presence of oxygen and hydrogen peroxide.	Oxygen	107-113	tyrosinase	Equus caballus	23-33
11472975-10	2001	In situ hybridization studies demonstrated increases in SP-D, and to a lesser extent in SP-A, in peripheral lung tissues from oxygen-exposed newborns.	Oxygen	126-132	surfactant protein A1	Rattus norvegicus	88-92
11513327-0	2001	Hyperbaric O2 reduces intestinal ischemia-reperfusion-induced TNF-alpha production and lung neutrophil sequestration.	Oxygen	11-13	tumor necrosis factor	Rattus norvegicus	62-71
11431362-2	2001	Oxygen-dependent degradation of HIF-1alpha, the regulatory subunit, requires binding to the von Hippel Lindau (VHL) protein.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
11529507-5	2001	Under the lowered O2 conditions, we noted a remarkable increase in the percentage of large-sized colonies, activation of cell cycle progression factors, phosphorylation of Akt, and downregulation of the cell cycle inhibitor p27Kip1.	Oxygen	18-20	AKT serine/threonine kinase 1	Rattus norvegicus	172-175
11454738-9	2001	Surprisingly, we found that HIF-1 alpha is stabilized by hypoxia and undergoes O(2)-dependent proteasomal degradation with an identical half-life (5--8 min) in both cellular compartments.	Oxygen	79-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-39
11438210-12	2001	NMDAR1 was expressed at a 1.5- to 1.8-fold higher level at 5% O2.	Oxygen	62-64	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	0-6
11412041-0	2001	Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells.	Oxygen	0-6	TIMP metallopeptidase inhibitor 1	Homo sapiens	45-85
11438210-13	2001	Twenty percent O2 supported higher expression of the Mk-early and -late-maturation-specific transcription factors GATA-1 (1.2- to 2.2-fold higher) and NF-E2 (1.1- to 2.8-fold higher).	Oxygen	15-17	GATA binding protein 1	Homo sapiens	114-120
11438210-13	2001	Twenty percent O2 supported higher expression of the Mk-early and -late-maturation-specific transcription factors GATA-1 (1.2- to 2.2-fold higher) and NF-E2 (1.1- to 2.8-fold higher).	Oxygen	15-17	nuclear factor, erythroid 2	Homo sapiens	151-156
11438210-14	2001	This was consistent with RT-PCR data indicating the presence of higher levels of GATA-1 and NF-E2 mRNA at 20% O2.	Oxygen	110-112	GATA binding protein 1	Homo sapiens	81-87
11697117-8	2001	The addition of SOD results in purging a reaction mixture from O2.- and, as a corollary, in depressing undesirable reactions with the participation of O2.-.	Oxygen	63-65	superoxide dismutase 1	Homo sapiens	16-19
11438210-14	2001	This was consistent with RT-PCR data indicating the presence of higher levels of GATA-1 and NF-E2 mRNA at 20% O2.	Oxygen	110-112	nuclear factor, erythroid 2	Homo sapiens	92-97
11697117-8	2001	The addition of SOD results in purging a reaction mixture from O2.- and, as a corollary, in depressing undesirable reactions with the participation of O2.-.	Oxygen	151-153	superoxide dismutase 1	Homo sapiens	16-19
11479740-1	2001	Catalase is an important antioxidant enzyme that detoxifies H2O2 into oxygen and water and thus limits the deleterious effects of reactive oxygen species (ROS).	Oxygen	70-76	catalase	Homo sapiens	0-8
11455199-0	2001	Oxygen-induced seizures and inhibition of human glutamate decarboxylase and porcine cysteine sulfinic acid decarboxylase by oxygen and nitric oxide.	Oxygen	124-130	glutamate-ammonia ligase	Homo sapiens	48-71
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	integrin linked kinase	Homo sapiens	64-86
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	integrin linked kinase	Homo sapiens	88-91
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	fibronectin 1	Homo sapiens	94-105
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	erythropoietin	Homo sapiens	246-249
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	251-256
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	integrin linked kinase	Homo sapiens	64-86
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	integrin linked kinase	Homo sapiens	88-91
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	fibronectin 1	Homo sapiens	94-105
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	erythropoietin	Homo sapiens	246-249
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	hypoxia inducible factor 1 subunit alpha	Homo sapiens	251-256
11408933-10	2001	To our knowledge this is the first report implicating the ILK pathway in low oxygen responses.	Oxygen	77-83	integrin linked kinase	Homo sapiens	58-61
11444502-3	2001	Previous studies have shown that oxygen-derived free radicals can increase the synthesis of endothelin-1 in cultured endothelial cells.	Oxygen	33-39	endothelin 1	Homo sapiens	92-104
11444502-11	2001	We conclude that oxygen-derived free radicals can stimulate the synthesis of endothelin-1 in endothelial and vascular smooth muscle cells by increasing preproendothelin-1 mRNA content and that this effect is mediated predominantly by superoxide anions.	Oxygen	17-23	endothelin 1	Homo sapiens	77-89
11444502-11	2001	We conclude that oxygen-derived free radicals can stimulate the synthesis of endothelin-1 in endothelial and vascular smooth muscle cells by increasing preproendothelin-1 mRNA content and that this effect is mediated predominantly by superoxide anions.	Oxygen	17-23	endothelin 1	Homo sapiens	152-170
11455199-1	2001	The recombinant forms of the two human isozymes of glutamate decarboxylase, GAD65 and GAD67, are potently and reversibly inhibited by molecular oxygen (Ki = 0.46 and 0.29 mM, respectively).	Oxygen	144-150	glutamate-ammonia ligase	Homo sapiens	51-74
11455199-1	2001	The recombinant forms of the two human isozymes of glutamate decarboxylase, GAD65 and GAD67, are potently and reversibly inhibited by molecular oxygen (Ki = 0.46 and 0.29 mM, respectively).	Oxygen	144-150	glutamate decarboxylase 2	Homo sapiens	76-81
11455199-2	2001	Inhibition of the vesicle-associated glutamate decarboxylase (GAD65) by molecular oxygen is likely to result in incomplete filling of synaptic vesicles with gamma-aminobutyric acid (GABA) and may be a contributing factor in the genesis of oxygen-induced seizures.	Oxygen	82-88	glutamate-ammonia ligase	Homo sapiens	37-60
11455199-2	2001	Inhibition of the vesicle-associated glutamate decarboxylase (GAD65) by molecular oxygen is likely to result in incomplete filling of synaptic vesicles with gamma-aminobutyric acid (GABA) and may be a contributing factor in the genesis of oxygen-induced seizures.	Oxygen	82-88	glutamate decarboxylase 2	Homo sapiens	62-67
11455199-2	2001	Inhibition of the vesicle-associated glutamate decarboxylase (GAD65) by molecular oxygen is likely to result in incomplete filling of synaptic vesicles with gamma-aminobutyric acid (GABA) and may be a contributing factor in the genesis of oxygen-induced seizures.	Oxygen	239-245	glutamate-ammonia ligase	Homo sapiens	37-60
11478413-7	2001	Tracheal concentrations of IL-8 and MCP-1 were significantly increased in infants who developed BPD (IL-8: P=0.0001; MCP-1: P&lt;0.001, analysis of variance) and correlated with duration of mechanical ventilation and oxygen treatment.	Oxygen	217-223	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11455199-2	2001	Inhibition of the vesicle-associated glutamate decarboxylase (GAD65) by molecular oxygen is likely to result in incomplete filling of synaptic vesicles with gamma-aminobutyric acid (GABA) and may be a contributing factor in the genesis of oxygen-induced seizures.	Oxygen	239-245	glutamate decarboxylase 2	Homo sapiens	62-67
11455199-5	2001	Similar inhibition of glutamate decarboxylase and cysteine sulfinic acid decarboxylase by two different radical-containing compounds (O2 and NO) is consistent with the notion that these reactions proceed via radical mechanisms.	Oxygen	134-136	glutamate-ammonia ligase	Homo sapiens	22-45
11448753-5	2001	On the contrary, high oxygen supply promoted some NR inactivation.	Oxygen	22-28	nitrate reductase [NADH]-like	Cucumis sativus	50-52
11466560-13	2001	Since tubular hypertrophy depends on G(1)-phase arrest and may promote subsequent development of interstitial fibrosis, administering oxygen radical scavenger may be a therapeutic tool to counteract ANG II dependent remodeling of renal tubular cells.	Oxygen	134-140	angiotensinogen	Rattus norvegicus	199-205
11473689-0	2001	Mitochondrial alternative oxidase acts to dampen the generation of active oxygen species during a period of rapid respiration induced to support a high rate of nutrient uptake.	Oxygen	74-80	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	14-33
11473689-9	2001	Rather, we provide in vivo evidence that the utilization of AOX during the period of high respiration supporting P uptake was to dampen the mitochondrial generation of active oxygen species (AOS).	Oxygen	175-181	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	60-63
11439222-8	2001	Oxygen species may be involved in the mechanism of TCHQ intoxication since the urinary 8-epi-PGF2alpha and AST, ALT activities can be induced by TCHQ and attenuated by vitamin E treatment.	Oxygen	0-6	solute carrier family 17 member 5	Homo sapiens	107-110
11441215-9	2001	CONCLUSIONS: These results indicate that oxygen-derived free radicals, particularly superoxide, play an important role in the iNOS gene expression after SAH and provide a molecular basis for the protective role of SOD against vasospasm after SAH.	Oxygen	41-47	nitric oxide synthase 2, inducible	Mus musculus	126-130
11531102-4	2001	(2) Low oxygen partial pressure increased the reductive metabolism of CCl4 and thus covalent binding.	Oxygen	8-14	C-C motif chemokine ligand 4	Rattus norvegicus	70-74
11294857-8	2001	Thus, reduced oxygen tension regulates apoptosis in PC12 cells through activation of the PI3K/Akt survival pathway.	Oxygen	14-20	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
11432561-10	2001	COS, the main product, is formed by the catalytic oxidizing reaction of CS2 with adsorbed "molecular" oxygen overthe catalysts" surfaces.	Oxygen	102-108	chorionic somatomammotropin hormone 2	Homo sapiens	72-75
11412976-2	2001	The energetic and structural results point to the Ile to Val mutation at residue 523 as the key contributor to COX-2 selectivity; unfavorable steric contact between a sulfonamide oxygen and the delta methyl group of Ile523 destabilizes the complex with COX-1.	Oxygen	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
11475152-1	2001	The rare hemoglobinopathies with abnormal oxygen binding are usually characterized by erythropoietin-mediated erythrocytosis.	Oxygen	42-48	erythropoietin	Homo sapiens	86-100
11410286-4	2001	The distal residue hinders the access to the iron(III) center of hemin-HSA to small anionic ligands like azide and cyanide and destabilizes the binding of neutral diatomics like dioxygen and carbon monoxide to the iron(II) form.	Oxygen	178-186	albumin	Homo sapiens	71-74
11389602-8	2001	This behavior distinguishes iNOS from the other NOS isoforms and indicates a more complex regulation is possible for its activity and oxygen response in biologic settings.	Oxygen	134-140	nitric oxide synthase 2, inducible	Mus musculus	28-32
11278461-3	2001	Until now, the expression and function of HIF-1alpha have not been studied in fish, which experience wide fluctuations of oxygen tensions in their natural environment.	Oxygen	122-128	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	42-52
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	109-115	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	20-30
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	147-151	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	20-30
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	224-228	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	20-30
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	224-228	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	190-200
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	250-256	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	20-30
11278461-8	2001	The accumulation of HIF-1alpha was studied by incubating rainbow trout and chinook salmon cells at different oxygen concentrations from 20 to 0.2% O(2) for 1 h. The greatest accumulation of HIF-1alpha protein occurred at 5% O(2) (38 torr), a typical oxygen tension of venous blood in normoxic animals.	Oxygen	250-256	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	190-200
11278461-10	2001	Notably, the hypoxia response element of oxygen-dependent degradation domain is identical in mammalian, Xenopus, and rainbow trout HIF-1alpha proteins, suggesting a high degree of evolutionary conservation in degradation of HIF-1alpha protein.	Oxygen	41-47	hypoxia-inducible factor 1-alpha	Oncorhynchus mykiss	131-141
11381139-8	2001	In addition, cultured Arnt2(-/-) neurons display decreased hypoxic induction of HIF-1 target genes, demonstrating formally that ARNT2/HIF-1alpha complexes regulate oxygen-responsive genes.	Oxygen	164-170	aryl hydrocarbon receptor nuclear translocator 2	Mus musculus	22-27
11381139-8	2001	In addition, cultured Arnt2(-/-) neurons display decreased hypoxic induction of HIF-1 target genes, demonstrating formally that ARNT2/HIF-1alpha complexes regulate oxygen-responsive genes.	Oxygen	164-170	aryl hydrocarbon receptor nuclear translocator 2	Mus musculus	128-133
11350731-0	2001	Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis.	Oxygen	80-86	vascular endothelial growth factor A	Homo sapiens	0-34
11472414-7	2001	Caspase-3 was implicated in the two models of apoptosis, the ratios of several survival proteins to Bax decreased, regardless of the ability of apo+ AECA to activate the cells, while radical oxygen species did not appear to be involved.	Oxygen	191-197	caspase 3	Homo sapiens	0-9
11385563-7	2001	Here we show that MgB2 thin films that are alloyed with oxygen can exhibit a much steeper temperature dependence of H*(T) than is observed in bulk materials, yielding an H* value at 4.2 K greater than 14 T. In addition, very high critical current densities at 4.2 K are achieved: 1 MA cm-2 at 1 T and 105 A cm-2 at 10 T. These results demonstrate that MgB2 has potential for high-field superconducting applications.	Oxygen	56-62	secretoglobin family 2A member 1	Homo sapiens	18-22
11389899-1	2001	The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
11389899-1	2001	The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
11480378-5	2001	Beta blockers, nitrates, and angiotensin converting enzyme inhibitors diminish myocardial oxygen consumption and have been shown to decrease morbidity and mortality.	Oxygen	90-96	angiotensin I converting enzyme	Homo sapiens	29-58
11530815-7	2001	In conclusion, an oxygen-induced modulation of the rate of photoreceptor degeneration was more marked in the hsp70.1 knockout type than wild type rd mice.	Oxygen	18-24	heat shock protein 1B	Mus musculus	109-116
11436522-2	2001	In the CPR laboratory, vasopressin improved vital organ blood flow, cerebral oxygen delivery, resuscitability, and neurologic recovery more than did epinephrine.	Oxygen	77-83	arginine vasopressin	Homo sapiens	23-34
11410240-6	2001	These findings suggest that FeMPy(4)P as SOD mimic converts intracellular O2(*-) to H(2)O(2) and that it rapidly reacts with H(2)O(2) to form *OH, causing DNA damage and inducing cell death.	Oxygen	74-76	superoxide dismutase 1	Homo sapiens	41-44
11348637-1	2001	A membrane bound cytochrome b(558) (NADPH oxidase) is a candidate for the oxygen sensor in pulmonary neuroepithelial bodies (NEBs) - putative airway chemoreceptors.	Oxygen	74-80	cytochrome b, mitochondrial	Mus musculus	17-29
11385563-7	2001	Here we show that MgB2 thin films that are alloyed with oxygen can exhibit a much steeper temperature dependence of H*(T) than is observed in bulk materials, yielding an H* value at 4.2 K greater than 14 T. In addition, very high critical current densities at 4.2 K are achieved: 1 MA cm-2 at 1 T and 105 A cm-2 at 10 T. These results demonstrate that MgB2 has potential for high-field superconducting applications.	Oxygen	56-62	secretoglobin family 2A member 1	Homo sapiens	352-356
11309002-1	2001	BACKGROUND: The hemoglobin-oxygen affinity is conveniently described as the oxygen tension at which the hemoglobin is 50% saturated (p50).	Oxygen	27-33	nuclear factor kappa B subunit 1	Homo sapiens	133-136
11349005-1	2001	Oxygen-derived free radicals are involved in the vascular response to angiotensin II (Ang II), but the role of NADPH oxidase, its subunit proteins, and their vascular localization remain controversial.	Oxygen	0-6	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	70-84
11349005-1	2001	Oxygen-derived free radicals are involved in the vascular response to angiotensin II (Ang II), but the role of NADPH oxidase, its subunit proteins, and their vascular localization remain controversial.	Oxygen	0-6	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	86-92
11278694-5	2001	Similar to many other von Hippel-Lindau tumor-suppressor protein (pVHL) targets, the expression of STRA13 on the mRNA level was hypoxia-sensitive, indicating oxygen-dependent regulation of the gene, presumably through the pVHL/hypoxia-inducible factor 1 (HIF-1) pathway.	Oxygen	158-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	255-260
11336512-1	2001	The von Hippel-Lindau tumor-suppressor protein (pVHL) regulates the stability of HIF1 alpha and HIF2 alpha and thus is pivotal in cellular responses to changes in oxygen tension.	Oxygen	163-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
11309002-1	2001	BACKGROUND: The hemoglobin-oxygen affinity is conveniently described as the oxygen tension at which the hemoglobin is 50% saturated (p50).	Oxygen	76-82	nuclear factor kappa B subunit 1	Homo sapiens	133-136
11309002-7	2001	CONCLUSIONS: The Siggaard-Andersen oxygen status algorithm is presently the most clinically useful single-point method of p50 calculation.	Oxygen	35-41	nuclear factor kappa B subunit 1	Homo sapiens	122-125
11377166-8	2001	These observations lead to the logical conclusion that a high degree of acetyl group transfer capability is conferred when the acetoxy group on the benzenoid ring of the coumarin system is in closer proximity to the oxygen heteroatom, i.e., when the acetoxy groups are at the C-7 and C-8 positions.	Oxygen	216-222	complement C7	Rattus norvegicus	276-279
11396794-0	2001	Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by O2 availability in vitro and in vivo.	Oxygen	110-112	vascular endothelial growth factor A	Homo sapiens	0-34
11396794-2	2001	Mediated by the hypoxia-inducible transcription factor HIF-1alpha/beta, a reduction in O2 tension (pO2) leads to increased VEGF gene expression in nonmalignant tissues.	Oxygen	87-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
11396794-2	2001	Mediated by the hypoxia-inducible transcription factor HIF-1alpha/beta, a reduction in O2 tension (pO2) leads to increased VEGF gene expression in nonmalignant tissues.	Oxygen	87-89	vascular endothelial growth factor A	Homo sapiens	123-127
11396794-5	2001	For in vitro study MX-1 cultures were grown on dishes with a gas-permeable bottom to expose the cells to defined O2 concentrations (from 95% to 0%) for 4 h. Northern blot analysis showed significant VEGF mRNA in MX-1 cultures under normoxic conditions which was further increased by hypoxia.	Oxygen	113-115	vascular endothelial growth factor A	Homo sapiens	199-203
11356124-7	2001	However, one common theme that is emerging with the angiogenic growth factors, such as vascular endothelial growth factor and the angiopoietins, is the transcriptional control of these genes by oxygen tension within the placenta.	Oxygen	194-200	vascular endothelial growth factor A	Homo sapiens	87-121
11409648-9	2001	We further examined the effects of antioxidants on Ang II-induced increases in oxygen consumption as an index of ROS generation in RASMC.	Oxygen	79-85	angiotensinogen	Rattus norvegicus	51-57
11526789-4	2001	The observed increase in oxygen activity of neutrophils was statistically significant only in reaction with the use of fMLP.	Oxygen	25-31	formyl peptide receptor 1	Homo sapiens	119-123
11409648-10	2001	DPI strongly inhibited Ang II-induced increases in oxygen consumption.	Oxygen	51-57	angiotensinogen	Rattus norvegicus	23-29
11409648-11	2001	DETC also inhibited Ang II-induced oxygen consumption, whereas ascorbic acid markedly augmented it.	Oxygen	35-41	angiotensinogen	Rattus norvegicus	20-26
11328942-0	2001	Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11313373-3	2001	Hypoxia is a condition of low oxygen tension, occurring in several pathological tissues, which acts in synergy with IFN-gamma to induce full Mphi activation.	Oxygen	30-36	interferon gamma	Mus musculus	116-125
11313373-10	2001	In conclusion, the engineered Mphi, which produce IFN-gamma in an inducible manner, express new biochemical and functional properties in response to low oxygen environment as the sole stimulus, thereby circumventing the need for costimulation by other immune system-derived signals.	Oxygen	153-159	interferon gamma	Mus musculus	50-59
11382829-13	2001	CONCLUSIONS: Hyperbaric oxygenation in healthy volunteers can induce not only lipid peroxidation, but also liberation of compounds such as TNFa and endothelins, no matter whether pure oxygen is breathed or not.	Oxygen	24-30	tumor necrosis factor	Homo sapiens	139-143
11382829-13	2001	CONCLUSIONS: Hyperbaric oxygenation in healthy volunteers can induce not only lipid peroxidation, but also liberation of compounds such as TNFa and endothelins, no matter whether pure oxygen is breathed or not.	Oxygen	24-30	endothelin 1	Homo sapiens	148-159
11424471-6	2001	However, the SpO2 decreased to 84-88% under oxygen administration by mask at a rate of 3 l.min-1.	Oxygen	44-50	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
11328942-1	2001	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11328942-1	2001	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11306436-0	2001	Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos.	Oxygen	46-52	transforming growth factor, beta 1	Rattus norvegicus	103-114
11304553-1	2001	Manganese superoxide dismutase 2 (SOD2) is a critical component of the mitochondrial pathway for detoxification of O2(-), and targeted disruption of this locus leads to embryonic or neonatal lethality in mice.	Oxygen	115-117	superoxide dismutase 2, mitochondrial	Mus musculus	34-38
11312732-3	2001	The complex M40403 was previously shown to be a superoxide dismutase (SOD) catalyst with rates for the catalytic dismutation of superoxide to oxygen and hydrogen peroxide at pH = 7.4 of 1.2 x 10(+7) M(-1) s(-1).	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	48-68
11312732-3	2001	The complex M40403 was previously shown to be a superoxide dismutase (SOD) catalyst with rates for the catalytic dismutation of superoxide to oxygen and hydrogen peroxide at pH = 7.4 of 1.2 x 10(+7) M(-1) s(-1).	Oxygen	142-148	superoxide dismutase 1	Homo sapiens	70-73
11238001-7	2001	Our data reveal that hyperoxia inhibits proliferation in G1 and S phase and demonstrate that p53 and p21 retain their ability to affect G1 checkpoint control during exposure to elevated O2 levels.	Oxygen	186-188	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-104
11579424-1	2001	Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain, catalyzing the transfer of electrons from reduced cytochrome c to molecular oxygen.	Oxygen	166-172	cytochrome c, somatic	Homo sapiens	0-12
11579424-1	2001	Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain, catalyzing the transfer of electrons from reduced cytochrome c to molecular oxygen.	Oxygen	166-172	cytochrome c, somatic	Homo sapiens	140-152
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Oxygen	245-251	plasminogen activator, urokinase	Homo sapiens	89-92
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Oxygen	245-251	coagulation factor II, thrombin	Homo sapiens	123-131
11306467-2	2001	Because hypoxia-inducible factor (HIF)-1alpha plays an essential role in oxygen homeostasis in vitro, we explored the predictive potential of this factor in a cohort of 98 patients with squamous cell cancer of the oropharynx, who were treated by curative radiation therapy.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-45
11282084-9	2001	A 6 h oxygen deprivation with nitrogen resulted in elevated levels of Hsp60 (media: P=0.048), of Hsp72 (intima: P&lt;0.001 and media: P=0.004) and of Hsp73 (intima: P=0.029) in the saphenous vein.	Oxygen	6-12	heat shock protein family A (Hsp70) member 1A	Homo sapiens	97-102
11248550-1	2001	Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11309343-5	2001	Its potential as an intrinsic hypoxia marker arises from its dual control in hypoxic conditions by reduced oxidative phosphorylation and the hypoxia-inducible factor (HIF-1) oxygen-sensing pathway.	Oxygen	174-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-172
11248550-1	2001	Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11327741-7	2001	The infusion of LCT/MCT 1:1 emulsions increased oxygen consumption (VO2) from 340+/-10 to 398+/-15 ml/min, cardiac output (CO) from 8.8+/-0.2 to 9.5+/-0.5 L/min and CO2 production (VCO2) from 247+/-12 to 282+/-14 mL/min (P&lt;0.05).	Oxygen	48-54	solute carrier family 16 member 11	Homo sapiens	20-27
11248550-2	2001	The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-15
11247956-3	2001	We sought to determine the effect of chronic hypoxia (8 wk, inspired O2 fraction = 0.12) on skeletal muscle gene expression of VEGF, its receptors (flt-1 and flk-1), basic fibroblast growth factor, and transforming growth factor-beta1.	Oxygen	69-71	vascular endothelial growth factor A	Homo sapiens	127-131
11292660-8	2001	Tumor-induced angiogenesis may augment the oxygen consumption in tumors resulting in an increased expression of hypoxia-related, proangiogenic genes as well as of HSP27 and P-glycoprotein, which are involved in a multidrug resistance phenotype.	Oxygen	43-49	ATP binding cassette subfamily B member 1	Homo sapiens	173-187
11290707-9	2001	Furthermore, oxygen repression of the hypoxic HEM13 gene was not affected by the deletion nor was this putative ROX1 gene regulated positively by oxygen as is the case for the S. cerevisiae gene.	Oxygen	146-152	Rox1p	Saccharomyces cerevisiae S288C	112-116
11306431-1	2001	The objective of this study was to determine whether endogenous nitric oxide (NO), specifically the inducible NO synthase isoform (iNOS: NOS II), reduces or amplifies lung injury in mice breathing at a high oxygen tension.	Oxygen	207-213	nitric oxide synthase 2, inducible	Mus musculus	131-135
11491581-7	2001	Treatment with MAK at a dose of 500 mg/kg body weight daily for two months reduced the lipid peroxidation and lipofuscin pigment accumulation significantly in brain regions and it also helped in restoring the normal oxygen consumption in the older animals.	Oxygen	216-222	serine/threonine-protein kinase MAK	Cavia porcellus	15-18
28404337-0	2001	Effect of an inhaled beta-2 adrenergic receptor agonist on arterial partial pressure of oxygen in hypoxemic anesthetized horses.	Oxygen	88-94	adrenoceptor beta 2	Equus caballus	21-47
11289110-3	2001	Severe hypoxia (0.01% oxygen) initiated a signaling cascade by inducing the tyrosine phosphorylation of the platelet-derived growth factor (PDGF) receptor within 1 h of treatment and increasing receptor association with the p85 subunit of phosphatidylinositol 3-kinase (PI 3-K).	Oxygen	22-28	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	239-268
11136721-0	2001	Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.	Oxygen	123-129	diacylglycerol kinase beta	Homo sapiens	32-53
11136721-1	2001	Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adaptation to lowered oxygen environments.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11136721-1	2001	Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adaptation to lowered oxygen environments.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11136721-6	2001	Our results demonstrate for the first time that accumulation of phosphatidic acid through DGK underlines oxygen sensing and provide evidence for the involvement of this lipid kinase in the intracellular signaling that leads to HIF-1 activation.	Oxygen	105-111	diacylglycerol kinase beta	Homo sapiens	90-93
11257085-0	2001	Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart.	Oxygen	26-32	endothelin 1	Rattus norvegicus	0-12
11257085-11	2001	This unique oxygen-saving effect of ET-1 may play an adaptive role in the failing myocardium, in which local accumulation of ET-1 is present.	Oxygen	12-18	endothelin 1	Rattus norvegicus	36-40
11257085-11	2001	This unique oxygen-saving effect of ET-1 may play an adaptive role in the failing myocardium, in which local accumulation of ET-1 is present.	Oxygen	12-18	endothelin 1	Rattus norvegicus	125-129
11240256-8	2001	The pharmacodynamic effect of RSR13 on Hb-O(2) binding affinity was quantified by multipoint tonometry and expressed as an increase in p50, defined as the partial pressure of O(2) that results in 50% SaO(2).	Oxygen	42-46	nuclear factor kappa B subunit 1	Homo sapiens	135-138
11263877-2	2001	The sieves, and the few percent of the Al(III) sites within them that are replaced by catalytically active, transition-metal ions in high oxidation states (Co(III), Mn(III), Fe(III)), are designed so as to allow free access of oxygen in to and out of the interior of these high-area solids.	Oxygen	227-233	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	42-45
11253920-6	2001	That is, phenolic compounds having weak quenching activity against DPPH may enhance the LPO/H2O2-catalyzed oxidation of NAD(P)H or GSH to generate a large amount of O2*- or GS*.	Oxygen	94-96	lactoperoxidase	Homo sapiens	88-91
11179510-6	2001	The expression of catalase was significantly up-regulated at 20% O(2).	Oxygen	65-69	catalase	Homo sapiens	18-26
11224662-1	2001	In target organs, insulin switches substrate utilization from free fatty acids to glucose, a change that: (i) is oxygen-efficient; (ii) repletes glycogen stores; (iii) removes potentially toxic fatty acids; and (iv) restores intracellular potassium.	Oxygen	113-119	insulin	Homo sapiens	18-25
11179510-7	2001	However, when the cells were treated with Fe(3+)-NTA, the expression of catalase was markedly down-regulated under the condition of 20% O(2).	Oxygen	136-140	catalase	Homo sapiens	72-80
11285891-2	2001	The estimated areal extent of bottom dissolved oxygen concentration less than 2 mg L-1 during mid-summer surveys of 1993-2000 reached as high as 16,000 to 20,000 km2.	Oxygen	47-53	immunoglobulin kappa variable 1-16	Homo sapiens	83-86
11230720-6	2001	Plasma ET-1 showed positive correlations to lactate levels and PVRI, and negative correlations to cardiac output and oxygen delivery only in the LPS plus L-canavanine group, but not in the LPS plus vehicle group.	Oxygen	117-123	endothelin 1	Canis lupus familiaris	7-11
11302529-1	2001	Myoglobin is an important oxygen store for supporting aerobic diving in endotherms, yet little is known about its role during postnatal development.	Oxygen	26-32	myoglobin	Tursiops truncatus	0-9
11226418-1	2001	Bovine dopamine beta-hydroxylase (DbH) was inactivated by hydrogen peroxide and ascorbate in the presence of dioxygen.	Oxygen	109-117	dopamine beta-hydroxylase	Bos taurus	7-32
11228961-1	2001	The rate of oxidation of As(III) to As(V) by oxygen is increased by several orders of magnitude by the presence of dissolved Fe(III) and illumination with near ultraviolet light.	Oxygen	45-51	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-41
11261795-6	2001	This pro-apoptotic effect of TNF-alpha was blocked by anti-CD11b and was absent in neutrophils from patients with chronic granulomatous disease, which cannot produce toxic oxygen metabolites.	Oxygen	172-178	tumor necrosis factor	Homo sapiens	29-38
11226418-1	2001	Bovine dopamine beta-hydroxylase (DbH) was inactivated by hydrogen peroxide and ascorbate in the presence of dioxygen.	Oxygen	109-117	dopamine beta-hydroxylase	Bos taurus	34-37
11226425-0	2001	HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
11226425-0	2001	HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
11226425-1	2001	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
11226425-1	2001	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
11368345-6	2001	Moreover, monocytes stimulated with higher doses of cleaved AAT show an increase in cellular oxygen consumption by about 30%, while native AAT under the same experimental conditions inhibits oxygen consumption by about 50%.	Oxygen	93-99	serpin family A member 1	Homo sapiens	60-63
11159530-1	2001	The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-115
11159530-1	2001	The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-122
11159530-1	2001	The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
11368345-6	2001	Moreover, monocytes stimulated with higher doses of cleaved AAT show an increase in cellular oxygen consumption by about 30%, while native AAT under the same experimental conditions inhibits oxygen consumption by about 50%.	Oxygen	191-197	serpin family A member 1	Homo sapiens	60-63
11368345-6	2001	Moreover, monocytes stimulated with higher doses of cleaved AAT show an increase in cellular oxygen consumption by about 30%, while native AAT under the same experimental conditions inhibits oxygen consumption by about 50%.	Oxygen	191-197	serpin family A member 1	Homo sapiens	139-142
11159004-2	2001	Two and four weeks of hypoxia (10% O2) significantly increased right ventricular systolic pressure, the medial cross-sectional vascular wall area of the pulmonary arteries, and pulmonary ET-1 mRNA expression (2-fold and 3.2-fold, respectively).	Oxygen	35-37	endothelin 1	Rattus norvegicus	187-191
11221830-4	2001	Elevated cytochrome c levels were associated with enhanced cytochrome c oxidase-dependent oxygen uptake using TMPD/ascorbate as the electron donor, suggesting that the newly synthesized proteins were functional.	Oxygen	90-96	cytochrome c, somatic	Homo sapiens	9-21
11291601-11	2001	These studies provide evidence that reactive oxygen plays a significant role in signal transduction for activation via the transcription factor, NF-kappa B, thereby modulating distal actions and consequences of iNOS-derived nitric oxide.	Oxygen	45-51	nuclear factor kappa B subunit 1	Homo sapiens	145-155
11291601-11	2001	These studies provide evidence that reactive oxygen plays a significant role in signal transduction for activation via the transcription factor, NF-kappa B, thereby modulating distal actions and consequences of iNOS-derived nitric oxide.	Oxygen	45-51	nitric oxide synthase 2	Homo sapiens	211-215
11221830-4	2001	Elevated cytochrome c levels were associated with enhanced cytochrome c oxidase-dependent oxygen uptake using TMPD/ascorbate as the electron donor, suggesting that the newly synthesized proteins were functional.	Oxygen	90-96	cytochrome c, somatic	Homo sapiens	59-71
11156968-7	2001	Alteration of the phenotype by prior hypoxia exposure in the SOD2-deficient mutant provide a unique model to study adaptative mechanisms of cellular resistance to oxygen toxicity.	Oxygen	163-169	superoxide dismutase 2, mitochondrial	Mus musculus	61-65
11168446-6	2001	In patients with COLD or CLHF, plasma EPO was negatively correlated with both RBF and renal oxygen delivery (ROD) and positively correlated with filtration fraction.	Oxygen	92-98	erythropoietin	Homo sapiens	38-41
11156969-4	2001	Prestimulation of macrophages for 15 h with a combination of LPS/IFN-gamma attenuated oxygen radical formation in response to TPA.	Oxygen	86-92	interferon gamma	Homo sapiens	65-74
11264894-7	2001	The molsidomine metabolite (SIN-1), which was presumed to release both .NO and O2(7-) at pH 7.4, reacted with 5-HT differently, depending on the presence of reductant or oxidant.	Oxygen	79-81	MAPK associated protein 1	Homo sapiens	28-33
11264894-9	2001	The strong oxidant Cu2+, even in the presence of air oxygen, accelerated oxidation and increased .NO release from SIN-1 up to 86%.	Oxygen	53-59	MAPK associated protein 1	Homo sapiens	114-119
11264894-10	2001	Only a small part of SIN-1 gave simultaneously .NO and O2(7-) able to link together to give peroxynitrite, but other oxidants could enhance .NO release from SIN-1.	Oxygen	55-57	MAPK associated protein 1	Homo sapiens	21-26
11264894-10	2001	Only a small part of SIN-1 gave simultaneously .NO and O2(7-) able to link together to give peroxynitrite, but other oxidants could enhance .NO release from SIN-1.	Oxygen	55-57	MAPK associated protein 1	Homo sapiens	157-162
11168996-5	2001	OxLDL dose-dependently (10 to 300 microg/mL) stimulated O2- formation in HUVEC (detected by cytochrome c assay and by chemiluminescence of lucigenin).	Oxygen	56-58	cytochrome c, somatic	Homo sapiens	92-104
11322641-3	2001	The recombinant protein protected glutamine synthetase from oxidative damage caused by a metal ion-catalyzed oxidation system (ascorbate/Fe3+/O2) in the presence of dithiothreitol as an electron donor.	Oxygen	142-144	glutamate-ammonia ligase	Homo sapiens	34-54
11161842-11	2001	There was 2.7-fold suppression in expression immediately following oxygen exposure at P12.	Oxygen	67-73	polymerase (DNA-directed), delta 4	Mus musculus	86-89
11161842-15	2001	In summary, TNF-alpha is altered in the development of oxygen-induced retinopathy in the mouse.	Oxygen	55-61	tumor necrosis factor	Mus musculus	12-21
11161842-5	2001	Changes in TNF-alpha expression in the retina may play an important role in the development of oxygen-induced retinopathy.	Oxygen	95-101	tumor necrosis factor	Mus musculus	11-20
11201091-2	2001	The PS2 gene promoter contains multiple DNA binding sites for the relatively rare hypoxia-inducible transcription factor HIF-1, suggesting that PS2 expression may be a sensitive indicator of decreased oxygen availability.	Oxygen	201-207	presenilin 2	Rattus norvegicus	4-7
11161842-6	2001	Oxygen-induced retinopathy was produced in C57BL6 mice by exposure to 75% oxygen at Postnatal Day 7 (P7) for 5 days and the mice recovered in room air until Day 17 (P17).	Oxygen	0-6	family with sequence similarity 72, member A	Mus musculus	165-168
11161842-8	2001	TNF-alpha expression was evaluated at Day 7 prior to oxygen exposure, at Day 12 (P12) immediately upon removal from oxygen, and at Day 17, the time of maximal vasoproliferation by RT-PCR.	Oxygen	53-59	tumor necrosis factor	Mus musculus	0-9
11710394-11	2001	On the contrary, myocardial NO generation and iNOS expression were significantly reduced after repeated inhalation of hypobaric oxygen at 5500 m. NO metabolism regained to normal after repeated administration of TP.	Oxygen	128-134	nitric oxide synthase 2, inducible	Mus musculus	46-50
11481030-2	2001	It has been suggested that both reactive oxygen and nitrogen metabolites participate in regulating adhesion molecule expression in response to TNF-alpha.	Oxygen	41-47	tumor necrosis factor	Homo sapiens	143-152
11042174-13	2001	Several mechanisms are proposed for O2 adduct formation followed by decomposition to NO3- or by oxidation of an HN2O3- molecule to form NO2-.	Oxygen	36-38	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
11950139-1	2001	The major function of the erythrocyte is to transport oxygen from the lungs to the other tissues, a function ensured by the glycoprotein hormone erythropoietin which couples red cell production to long term tissue oxygen requirements.	Oxygen	54-60	erythropoietin	Homo sapiens	145-159
11950139-1	2001	The major function of the erythrocyte is to transport oxygen from the lungs to the other tissues, a function ensured by the glycoprotein hormone erythropoietin which couples red cell production to long term tissue oxygen requirements.	Oxygen	214-220	erythropoietin	Homo sapiens	145-159
11950150-3	2001	HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis.	Oxygen	72-78	Hypoxia-inducible factor 1	Caenorhabditis elegans	0-5
11999809-7	2001	O2 ventilation greatly affected the prostanoid synthesis of the microvessels, with an enhancement of PGD2 up to 247 +/- 27%.	Oxygen	0-2	prostaglandin D2 synthase	Homo sapiens	101-105
12162583-8	2001	The greatest oxygen uptake relative to body mass was found in the modern pentathlonists (73.22 ml x kg(-1) x min(-1)) and the lowest one (59.79) in the water polo players.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	109-115
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	151-153	erythropoietin	Homo sapiens	54-68
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	151-153	erythropoietin	Homo sapiens	70-73
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	151-153	vascular endothelial growth factor A	Homo sapiens	79-113
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	151-153	vascular endothelial growth factor A	Homo sapiens	115-119
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	240-242	erythropoietin	Homo sapiens	54-68
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	240-242	erythropoietin	Homo sapiens	70-73
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	240-242	vascular endothelial growth factor A	Homo sapiens	79-113
11950137-1	2001	Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.	Oxygen	240-242	vascular endothelial growth factor A	Homo sapiens	115-119
11216750-9	2001	Hearts in the insulin group displayed higher myocardial oxygen extraction than those in the blood group.	Oxygen	56-62	insulin	Homo sapiens	14-21
11146880-2	2001	Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that stimulate tumour vascularization.	Oxygen	20-26	tumor protein p53	Homo sapiens	65-68
11146880-4	2001	In this paper a mathematical model is presented to investigate the effects of alternating periods of hypoxia and normoxia (normal oxygen levels) on a population of wild-type and mutant p53 tumour cells.	Oxygen	130-136	tumor protein p53	Homo sapiens	185-188
11133970-0	2001	O2R, a novel regulatory element mediating Rox1p-independent O(2) and unsaturated fatty acid repression of OLE1 in Saccharomyces cerevisiae.	Oxygen	60-64	Rox1p	Saccharomyces cerevisiae S288C	42-47
11353933-13	2001	In the mesenteric circulation, dopamine at 32 microg kg-1 min-1 increased portal venous flow and total hepatic blood flow and oxygen delivery, and decreased MVRI; epinephrine had no effect on these variables.	Oxygen	126-132	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
11115828-9	2001	Hypoxia (1% oxygen) resulted in profound upregulation of VEGF mRNA and protein levels.	Oxygen	12-18	vascular endothelial growth factor A	Homo sapiens	57-61
11124232-0	2001	Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site.	Oxygen	80-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104
11134892-0	2001	Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.	Oxygen	9-15	fibronectin 1	Homo sapiens	50-61
11133899-6	2001	In contrast, acute hypoxic exercise decreased CCK by 7.0 +/- 5.5 pmol/l, which correlated with the decrease in arterial oxygen saturation (r = 0.56, P &lt; 0.05).	Oxygen	120-126	cholecystokinin	Homo sapiens	46-49
11133970-3	2001	It has been proposed that aerobic conditions lead to repression of OLE1 by well-established O(2)-responsive repressor Rox1p, since putative binding sequences for Rox1p are present in the promoter of OLE1.	Oxygen	92-96	Rox1p	Saccharomyces cerevisiae S288C	118-123
11133970-3	2001	It has been proposed that aerobic conditions lead to repression of OLE1 by well-established O(2)-responsive repressor Rox1p, since putative binding sequences for Rox1p are present in the promoter of OLE1.	Oxygen	92-96	Rox1p	Saccharomyces cerevisiae S288C	162-167
11136607-1	2001	Myoglobin is an important storage site for oxygen in the swimming muscles of diving marine mammals.	Oxygen	43-49	myoglobin	Tursiops truncatus	0-9
11136607-12	2001	These results show that myoglobin is not homogeneously distributed in the locomotory muscle of cetaceans and that levels may be highest in those areas that produce greater force and consume more oxygen during aerobic swimming.	Oxygen	195-201	myoglobin	Tursiops truncatus	24-33
11770031-12	2001	An inverse relationship was found for IL-10 (IL-6) levels and venous O2 saturation (SvO2), and mean arterial pressure (MAP).	Oxygen	69-71	interleukin 6	Homo sapiens	45-49
11501491-11	2001	Moreover, the VEGF level was negatively correlated with oxygen saturation (y = 440.6-3.53x, R = 0.47, p &lt; 0.0001) in cases more than 3 months old.	Oxygen	56-62	vascular endothelial growth factor A	Homo sapiens	14-18
11501491-13	2001	Although physiologically increased VEGF in the neonatal period was rapidly decreased under normal oxygen saturation, a higher VEGF level persisted if systemic hypoxia was present.	Oxygen	98-104	vascular endothelial growth factor A	Homo sapiens	35-39
21336918-2	2001	After activation of cellular phospholipases and release of free arachidonic acid, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2).	Oxygen	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
11746908-7	2001	A second mechanism involves nucleophilic attack of the phosphate oxygen on the sn-1 and sn-2 glycerol backbone to form carboxylate anions with neutral loss of cyclo lyso-phospholipids.	Oxygen	65-71	solute carrier family 38 member 3	Homo sapiens	79-83
11746908-7	2001	A second mechanism involves nucleophilic attack of the phosphate oxygen on the sn-1 and sn-2 glycerol backbone to form carboxylate anions with neutral loss of cyclo lyso-phospholipids.	Oxygen	65-71	solute carrier family 38 member 5	Homo sapiens	88-92
11217146-1	2001	BACKGROUND: The antioxidant enzyme Cu/Zn-superoxide dismutase-1 (SOD1) gene is localized to chromosome 21q22.1 and catalyzes the dismutation of superoxide anions to hydrogen peroxide, which may lead to the increased production of active oxygen species in Down Syndrome (DS), trisomy 21.	Oxygen	237-243	superoxide dismutase 1	Homo sapiens	35-63
11217146-1	2001	BACKGROUND: The antioxidant enzyme Cu/Zn-superoxide dismutase-1 (SOD1) gene is localized to chromosome 21q22.1 and catalyzes the dismutation of superoxide anions to hydrogen peroxide, which may lead to the increased production of active oxygen species in Down Syndrome (DS), trisomy 21.	Oxygen	237-243	superoxide dismutase 1	Homo sapiens	65-69
11211748-4	2001	Anesthesia was maintained with about 1% of sevoflurane, with nitrous oxide 3 l.min-1 in oxygen 3 l.min-1.	Oxygen	88-94	CD59 molecule (CD59 blood group)	Homo sapiens	79-84
11497223-6	2001	The suppressive effect of EPA was mediated via the production of reactive oxygen products, because EPA-stimulated H2O2 production and the suppressive effect of EPA was restored by addition of catalase or NAC.	Oxygen	74-80	catalase	Homo sapiens	192-200
11727931-3	2001	The central mediator of this response is a DNA binding complex termed hypoxia inducible factor 1 (HIF-1), which plays a key role in the regulation by oxygen of a large and rapidly growing panel of genes.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-96
11727931-3	2001	The central mediator of this response is a DNA binding complex termed hypoxia inducible factor 1 (HIF-1), which plays a key role in the regulation by oxygen of a large and rapidly growing panel of genes.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-103
11727931-13	2001	Equally regulation of the HIF-1alpha/pVHL interaction in normal cells should provide insights into the physiological mechanisms operating in cellular oxygen sensing.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-36
11354698-9	2001	The provision of supplemental oxygen causes retinal hyperoxia, a down regulation of vascular endothelial growth factor (VEGF) and a consequent cessation of normal retinal vascularisation.	Oxygen	30-36	vascular endothelial growth factor A	Homo sapiens	84-118
11354698-9	2001	The provision of supplemental oxygen causes retinal hyperoxia, a down regulation of vascular endothelial growth factor (VEGF) and a consequent cessation of normal retinal vascularisation.	Oxygen	30-36	vascular endothelial growth factor A	Homo sapiens	120-124
11865975-2	2001	Furthermore, it has been proposed that BCL-2 acts to inhibit cell death by interfering with the production of oxygen-derived free radicals induced by a wide variety of stimuli.	Oxygen	110-116	BCL2 apoptosis regulator	Homo sapiens	39-44
11565117-3	2001	The author considers, that interleukin-8 is connected with high concentration of oxygen active forms in neutrophils in the patients with this stage of disease.	Oxygen	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
11463947-1	2001	Decreased oxygen (O2) levels activate hypoxia-inducible factor (HIF-1) to induce genes involved in glycolysis, glucose transport, erythropoiesis, and angiogenesis.	Oxygen	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
11463947-1	2001	Decreased oxygen (O2) levels activate hypoxia-inducible factor (HIF-1) to induce genes involved in glycolysis, glucose transport, erythropoiesis, and angiogenesis.	Oxygen	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
11134659-5	2000	Pravastatin at concentrations of 5, 100 and 500 microM caused an inhibition of TNF-alpha-induced cellular oxygen consumption from 2.	Oxygen	106-112	tumor necrosis factor	Homo sapiens	79-88
11708401-13	2001	Human studies of CK-M gene sequence variation have shown a significant association between a polymorphism, distinguished by the NcoI restriction enzyme, and an increase in cardiorespiratory endurance as indexed by maximal oxygen uptake following 20 weeks of training.	Oxygen	222-228	creatine kinase, M-type	Homo sapiens	17-21
16351833-3	2001	The hypoxia-inducible transcription factor HIF-1, a heterodimer consisting of the oxygen-regulated alpha-subunit and the constitutively expressed beta or ARNT-subunit, serves as a master regulator of oxygen-dependent gene expression.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
16351833-3	2001	The hypoxia-inducible transcription factor HIF-1, a heterodimer consisting of the oxygen-regulated alpha-subunit and the constitutively expressed beta or ARNT-subunit, serves as a master regulator of oxygen-dependent gene expression.	Oxygen	200-206	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
11112110-7	2000	Fibrinogen was positively correlated with RDI (r = 0.24, p = 0.007), duration of the longest apnea (r = 0.18, p = 0.049), and negatively correlated with several oxygen indices including average minimal oxygen saturation (r = -0.41, p &lt; 0.001).	Oxygen	161-167	fibrinogen beta chain	Homo sapiens	0-10
11124810-3	2000	Hypoxia-inducible factor-1 (HIF-1), consisting of HIF-1alpha and ARNT subunits, activates many genes involved in the cellular and organismal response to O(2) deprivation.	Oxygen	153-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11124810-3	2000	Hypoxia-inducible factor-1 (HIF-1), consisting of HIF-1alpha and ARNT subunits, activates many genes involved in the cellular and organismal response to O(2) deprivation.	Oxygen	153-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11124810-3	2000	Hypoxia-inducible factor-1 (HIF-1), consisting of HIF-1alpha and ARNT subunits, activates many genes involved in the cellular and organismal response to O(2) deprivation.	Oxygen	153-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
10988296-3	2000	In confluent fibroblast cultures, the decrease in the concentration of oxygen species was associated with diminished activity of the small GTPase Rac-1, a signal transducer directly involved in the ligand-dependent generation of oxygen-derived molecules, and was effectively mimicked by exposure of sparse cultures to dithiothreitol (DTT) and inhibitors of enzymes (phospholipase A2 and lipoxygenase) acting in the arachidonic acid cascade downstream of growth factor receptors and Rac-1.	Oxygen	71-77	phospholipase A2 group IB	Homo sapiens	366-399
11112110-7	2000	Fibrinogen was positively correlated with RDI (r = 0.24, p = 0.007), duration of the longest apnea (r = 0.18, p = 0.049), and negatively correlated with several oxygen indices including average minimal oxygen saturation (r = -0.41, p &lt; 0.001).	Oxygen	202-208	fibrinogen beta chain	Homo sapiens	0-10
11112110-9	2000	Multiple linear regression identified minimal mean oxygen saturation and sex as independent predictors of fibrinogen level.	Oxygen	51-57	fibrinogen beta chain	Homo sapiens	106-116
11141343-6	2000	Endothelial growth is influenced by a variety of soluble factors, and several of these are regulated by oxygen, for example, vascular endothelial growth factor (VEGF), angiopoietin 2, and soluble flt (a VEGF antagonist).	Oxygen	104-110	vascular endothelial growth factor A	Homo sapiens	125-159
11141343-6	2000	Endothelial growth is influenced by a variety of soluble factors, and several of these are regulated by oxygen, for example, vascular endothelial growth factor (VEGF), angiopoietin 2, and soluble flt (a VEGF antagonist).	Oxygen	104-110	vascular endothelial growth factor A	Homo sapiens	161-165
11122370-2	2000	Slices deprived of glucose/oxygen to mimic ischemia or those exposed to 1 mM glutamate for 1 h exhibited Cx43 dephosphorylation, epitope masking and gap junction internalization as revealed by Western blotting and Cx43 immunolocalization with various antibodies.	Oxygen	27-33	gap junction protein, alpha 1	Rattus norvegicus	105-109
11113716-1	2000	BACKGROUND: Erythropoietin (Epo), a growth factor produced by the kidney, is important in heart failure patients to promote oxygen delivery to tissues.	Oxygen	124-130	erythropoietin	Homo sapiens	12-26
11113716-1	2000	BACKGROUND: Erythropoietin (Epo), a growth factor produced by the kidney, is important in heart failure patients to promote oxygen delivery to tissues.	Oxygen	124-130	erythropoietin	Homo sapiens	28-31
11106607-4	2000	Furthermore, increases in NAD(P)H amplitude, whether mediated by interferon-gamma or by an oscillating electric field, signals increased production of reactive oxygen metabolites.	Oxygen	160-166	interferon gamma	Homo sapiens	65-81
11122370-2	2000	Slices deprived of glucose/oxygen to mimic ischemia or those exposed to 1 mM glutamate for 1 h exhibited Cx43 dephosphorylation, epitope masking and gap junction internalization as revealed by Western blotting and Cx43 immunolocalization with various antibodies.	Oxygen	27-33	gap junction protein, alpha 1	Rattus norvegicus	214-218
11237107-2	2000	A mev-1 (kn1) mutant of Caenorhabditis elegans, isolated on the basis of its methyl viologen (paraquat) hypersensitivity, is also hypersensitive to elevated oxygen levels.	Oxygen	157-163	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	2-7
11163089-0	2000	Role of CD4+ regulatory T cells in hyperbaric oxygen-mediated immune nonresponsiveness.	Oxygen	46-52	CD4 molecule	Homo sapiens	8-11
11093754-1	2000	Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor involved in the oxygen-dependent regulation of gene expression.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11120759-6	2000	Catalase, which dismutates H(2)O(2) to form water and oxygen, inhibited EDHF-mediated relaxation and hyperpolarization, but it did not affect endothelium-independent relaxation following treatment with the K(+) channel opener levcromakalim.	Oxygen	54-60	catalase	Mus musculus	0-8
11093754-1	2000	Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor involved in the oxygen-dependent regulation of gene expression.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11123679-4	2000	The targets for H-NS-mediated aerobic repression are the four oxygen-regulated promoters, designated P1, P2, P3 and P4.	Oxygen	62-68	replication initiation protein	Escherichia coli	101-118
11134568-5	2000	RESULTS: The expansion of CD34+ cells and of clonogenic progenitors was significantly lower in liquid cultures at 1-percent O(2) than at 20-percent O(2).	Oxygen	124-128	CD34 molecule	Homo sapiens	26-30
10880853-2	2000	The amyloid beta-peptide (A beta), a hallmark in the pathogenesis of AD and the main component of senile plaques, generates free radicals in a metal-catalyzed reaction inducing neuronal cell death by a reactive oxygen species mediated process which damage neuronal membrane lipids, proteins and nucleic acids.	Oxygen	211-217	amyloid beta precursor protein	Homo sapiens	26-32
11225716-4	2000	The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of &lt;93%).	Oxygen	311-317	interleukin 6	Homo sapiens	62-66
11134568-8	2000	However, the CD34+ cells that divided more than four times (PKH2 staining) were more numerous in liquid cultures incubated at 1-percent O(2).	Oxygen	136-140	CD34 molecule	Homo sapiens	13-17
10961998-1	2000	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes responsive to the lack of oxygen, including erythropoietin, vascular endothelial growth factor, glycolytic enzymes, and glucose transporters.	Oxygen	160-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11134568-9	2000	CONCLUSION: When cultured at 1-percent O(2) for 7 days in presence of IL-3 and SCF, the CD34+ cells present in apheresis components underwent more cell divisions and better maintained their primitive progenitor cell potential.	Oxygen	39-43	CD34 molecule	Homo sapiens	88-92
10961998-1	2000	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes responsive to the lack of oxygen, including erythropoietin, vascular endothelial growth factor, glycolytic enzymes, and glucose transporters.	Oxygen	160-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10961998-9	2000	A partial complex I deficiency and a mild reduction in intact cell oxygen consumption effectively prevented hypoxic induction of HIF-1alpha protein.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
11050162-7	2000	These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene.	Oxygen	72-78	tumor protein p53	Homo sapiens	202-205
11013136-1	2000	Cytochrome c oxidase (COX) catalyzes both electron transfer from cytochrome c to molecular oxygen and the concomitant vectorial proton pumping across the inner mitochondrial membrane.	Oxygen	91-97	cytochrome c, somatic	Homo sapiens	0-12
11095513-0	2000	VEGF release by retinal glia depends on both oxygen and glucose supply.	Oxygen	45-51	vascular endothelial growth factor A	Homo sapiens	0-4
11095513-2	2000	In both types of cultures, hypoxia (5% O2) resulted in an upregulated VEGF release.	Oxygen	39-41	vascular endothelial growth factor A	Homo sapiens	70-74
11013136-1	2000	Cytochrome c oxidase (COX) catalyzes both electron transfer from cytochrome c to molecular oxygen and the concomitant vectorial proton pumping across the inner mitochondrial membrane.	Oxygen	91-97	cytochrome c, somatic	Homo sapiens	65-77
11093007-1	2000	The aim of this study was to investigate the effect of recombinant human erythropoietin (rHu-EPO) on oxygen affinity and adequate oxygen delivery to the tissues of stable premature infants.	Oxygen	101-107	erythropoietin	Homo sapiens	73-87
11050012-3	2000	RA induced Epo production through the transcriptional activation of the Epo gene in an oxygen-independent manner.	Oxygen	87-93	erythropoietin	Homo sapiens	11-14
11050012-3	2000	RA induced Epo production through the transcriptional activation of the Epo gene in an oxygen-independent manner.	Oxygen	87-93	erythropoietin	Homo sapiens	72-75
11093007-1	2000	The aim of this study was to investigate the effect of recombinant human erythropoietin (rHu-EPO) on oxygen affinity and adequate oxygen delivery to the tissues of stable premature infants.	Oxygen	130-136	erythropoietin	Homo sapiens	73-87
11236678-0	2000	[Effect of hyperbaric oxygen on the expression of proteins Bcl-2 and Bax in the gerbil hippocampus CA1 following forebrain ischemia reperfusion].	Oxygen	22-28	BCL2 apoptosis regulator	Homo sapiens	59-64
11071299-9	2000	Cytochrome P450 4A blockers also attenuate the vasoconstrictor response to elevations in tissue PO2, suggesting that this system may serve as a vascular oxygen sensor.	Oxygen	153-159	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
11038155-6	2000	When the substrates were incubated with the CYP3A4-expressed microsomes under oxygen-18 gas phase, atmospheric oxygen was incorporated into 35% of 7-oxo-Delta(8)-THC formed from 7alpha-OH-Delta(8)-THC, but only 12% of 7-oxo-Delta(8)-THC formed from 7beta-OH-Delta(8)-THC.	Oxygen	78-84	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	44-50
11038155-6	2000	When the substrates were incubated with the CYP3A4-expressed microsomes under oxygen-18 gas phase, atmospheric oxygen was incorporated into 35% of 7-oxo-Delta(8)-THC formed from 7alpha-OH-Delta(8)-THC, but only 12% of 7-oxo-Delta(8)-THC formed from 7beta-OH-Delta(8)-THC.	Oxygen	111-117	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	44-50
11053346-1	2000	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian cells.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
11053346-1	2000	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian cells.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
11093698-0	2000	Dyspnea management in alpha-1 antitrypsin deficiency: effect of oxygen administration.	Oxygen	64-70	serpin family A member 1	Homo sapiens	22-41
11093698-2	2000	OBJECTIVE: The research addressed whether short-term oxygen (O2) administration during activities might decrease dyspnea and improve exercise performance in nonhypoxemic patients with emphysema caused by a deficiency of alpha-1 antitrypsin.	Oxygen	53-59	serpin family A member 1	Homo sapiens	220-239
11093698-2	2000	OBJECTIVE: The research addressed whether short-term oxygen (O2) administration during activities might decrease dyspnea and improve exercise performance in nonhypoxemic patients with emphysema caused by a deficiency of alpha-1 antitrypsin.	Oxygen	61-63	serpin family A member 1	Homo sapiens	220-239
11046005-8	2000	Our data show that the private signaling pathways of Dex (oxygen dependent) and anti-CD95 (oxygen independent) both converge upstream of mitochondrial changes.	Oxygen	58-64	Fas (TNF receptor superfamily member 6)	Mus musculus	85-89
11046005-8	2000	Our data show that the private signaling pathways of Dex (oxygen dependent) and anti-CD95 (oxygen independent) both converge upstream of mitochondrial changes.	Oxygen	91-97	Fas (TNF receptor superfamily member 6)	Mus musculus	85-89
11114704-3	2000	We propose that interleukin-2 therapy should be supplemented with compounds that alleviate toxicity inflicted by monocyte/macrophage-derived reactive oxygen metabolites within and around tumors.	Oxygen	150-156	interleukin 2	Homo sapiens	16-29
11114704-4	2000	The hypothesis is founded on data demonstrating that (i) functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen metabolites, generated by neighboring monocytes/macrophages, (ii) interleukin-2 only weakly activates T-cells or natural killer cells in an environment of oxidative stress, and (iii) inhibitors of the formation of reactive oxygen metabolites or scavengers of reactive oxygen metabolites synergize with interleukin-2 to activate these lymphocyte subsets.	Oxygen	152-158	interleukin 2	Homo sapiens	461-474
11114704-4	2000	The hypothesis is founded on data demonstrating that (i) functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen metabolites, generated by neighboring monocytes/macrophages, (ii) interleukin-2 only weakly activates T-cells or natural killer cells in an environment of oxidative stress, and (iii) inhibitors of the formation of reactive oxygen metabolites or scavengers of reactive oxygen metabolites synergize with interleukin-2 to activate these lymphocyte subsets.	Oxygen	382-388	interleukin 2	Homo sapiens	225-238
11114704-4	2000	The hypothesis is founded on data demonstrating that (i) functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen metabolites, generated by neighboring monocytes/macrophages, (ii) interleukin-2 only weakly activates T-cells or natural killer cells in an environment of oxidative stress, and (iii) inhibitors of the formation of reactive oxygen metabolites or scavengers of reactive oxygen metabolites synergize with interleukin-2 to activate these lymphocyte subsets.	Oxygen	382-388	interleukin 2	Homo sapiens	225-238
11236678-0	2000	[Effect of hyperbaric oxygen on the expression of proteins Bcl-2 and Bax in the gerbil hippocampus CA1 following forebrain ischemia reperfusion].	Oxygen	22-28	BCL2 associated X, apoptosis regulator	Homo sapiens	69-72
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	fibroblast growth factor 2	Homo sapiens	23-49
11041855-6	2000	It is concluded that the extrinsic subunits keep the S-LHCII and CP29 subunits in proper positions at some distance from the central part of the photosystem II core dimer to ensure a directed transfer of excitation energy through the monomeric peripheral antenna proteins CP26 and CP29 and/or to maintain sequestered domains of inorganic cofactors required for oxygen evolution.	Oxygen	361-367	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	272-276
11069105-2	2000	The AMP-activated protein kinase (AMPK) is activated when the oxygen supply is restricted.	Oxygen	62-68	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	4-32
11069105-2	2000	The AMP-activated protein kinase (AMPK) is activated when the oxygen supply is restricted.	Oxygen	62-68	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	34-38
11007955-5	2000	We show that oxygen-regulated HIF-1 alpha protein levels are not affected by intracellular localization (nucleus versus cytoplasm).	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-41
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	fibroblast growth factor 2	Homo sapiens	51-56
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	vascular endothelial growth factor A	Homo sapiens	61-95
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	vascular endothelial growth factor A	Homo sapiens	97-101
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	tumor necrosis factor	Homo sapiens	117-144
11023511-3	2000	hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF) together with tumor necrosis factor-alpha (TNF-alpha) formed 2- to 3-fold more tubular structures under hypoxic conditions than in normoxic (20% oxygen) conditions.	Oxygen	248-254	tumor necrosis factor	Homo sapiens	146-155
11007651-7	2000	A binding mode for pABA, sulfonamides and sulfones is suggested based on: (i) the new conformation of the closed loop 1; (ii) the distribution of dapsone and sulfonamide resistance mutations; (iii) the observed direction of the bond between the 6-methyl carbon atom and the bridging oxygen atom to the alpha-phosphate group in the Mtb DHPS:PtP binary complex; and (iv) the conformation of loop 2 in the Escherichia coli DHPS structure.	Oxygen	283-289	dihydropteroate synthetase	Escherichia coli	335-339
11196970-7	2000	The dioxygen complex 4a transfers one oxygen atom to PPh3 (to give Ph3PO) or oxidizes iodide ions to triiodide ions in the presence of anhydrous HCl.	Oxygen	4-12	caveolin 1	Homo sapiens	53-57
11196970-7	2000	The dioxygen complex 4a transfers one oxygen atom to PPh3 (to give Ph3PO) or oxidizes iodide ions to triiodide ions in the presence of anhydrous HCl.	Oxygen	6-12	caveolin 1	Homo sapiens	53-57
11007651-7	2000	A binding mode for pABA, sulfonamides and sulfones is suggested based on: (i) the new conformation of the closed loop 1; (ii) the distribution of dapsone and sulfonamide resistance mutations; (iii) the observed direction of the bond between the 6-methyl carbon atom and the bridging oxygen atom to the alpha-phosphate group in the Mtb DHPS:PtP binary complex; and (iv) the conformation of loop 2 in the Escherichia coli DHPS structure.	Oxygen	283-289	dihydropteroate synthetase	Escherichia coli	420-424
10921504-0	2000	Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.	Oxygen	34-40	nuclear factor kappa B subunit 1	Homo sapiens	108-117
11001767-9	2000	Coincubation of EC and ZG cells in 8% oxygen inhibited ANG II-induced aldosterone release, and inhibition was reversed by blockade of NOS.	Oxygen	38-44	angiotensinogen	Homo sapiens	55-61
11000584-7	2000	In addition, LAK cell-activated bid may have increased the intracellular reactive oxygen intermediates (ROI) level and induced a decrease of mitochondrial membrane potential.	Oxygen	82-88	BH3 interacting domain death agonist	Homo sapiens	32-35
11081979-1	2000	Hap1 and Rox1 are transcriptional regulators that bind regulatory sites in the promoters of oxygen-regulated genes in Saccharomyces cerevisiae.	Oxygen	92-98	Rox1p	Saccharomyces cerevisiae S288C	9-13
11004690-3	2000	The low oxygen tensions (hypoxia) present in these tumours are known to up-regulate the expression of VEGF by tumour cells.	Oxygen	8-14	vascular endothelial growth factor A	Homo sapiens	102-106
11043580-7	2000	The objective of the present study was to utilize cytotrophoblasts isolated from midterm human placenta to analyze the effects of O2 on CYP19 gene expression and the molecular mechanisms that mediate these effects.	Oxygen	130-132	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	136-141
11120915-7	2000	During exercise, the mean oxygen consumption levels were 1.70 +/- 0.10/ x min(-1) for L-SS and 1.75 +/- 0.11/ x min(-1) for H-SS (p = 0.07), respectively.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	74-80
11043580-9	2000	However, when cytotrophoblasts that had been maintained in 2% O2 for 3 days were placed in a 20% O2 environment, there was a rapid onset of cell fusion and induction of P450arom mRNA and aromatase activity.	Oxygen	62-64	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	169-177
11043580-9	2000	However, when cytotrophoblasts that had been maintained in 2% O2 for 3 days were placed in a 20% O2 environment, there was a rapid onset of cell fusion and induction of P450arom mRNA and aromatase activity.	Oxygen	97-99	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	169-177
11200255-3	2000	Differential binding of oligomers containing carbadU, 4"-thiodU, and dU residues to wild type and mutant UDG proteins identify an essential role for the furanose 4"-oxygen in recognition and cleavage of dU residues in DNA.	Oxygen	165-171	uracil DNA glycosylase	Homo sapiens	105-108
10970783-1	2000	Previous studies have established that constitutive calcium-dependent ("low-output") nitric oxide synthase (NOS) is regulated by oxygen tension.	Oxygen	129-135	nitric oxide synthase 2	Homo sapiens	85-106
10993914-5	2000	Retinol served as a cofactor to augment the activation of both cRaf and PKC alpha by reactive oxygen, whereas the classical receptor-mediated pathway was unaffected by the presence or absence of retinol.	Oxygen	94-100	protein kinase C alpha	Homo sapiens	72-81
11068948-2	2000	Circulating levels of erythropoietin are remarkably consistent across the range of normal hemoglobin levels; levels Increase markedly as hemoglobin declines below 12 g/dL In a manner suggesting that mechanisms in addition to the level of tissue oxygen are important in regulating increases in erythropoietin production and erythropoiesis.	Oxygen	245-251	erythropoietin	Homo sapiens	22-36
11129066-10	2000	In conclusion, this study showed that beta-endorphin concentrations are increased in COPD patients whether or not they receive oxygen therapy.	Oxygen	127-133	proopiomelanocortin	Homo sapiens	38-52
11372412-1	2000	OBJECTIVE: To study the relationship between placental vascular endothelial growth factor (VEGF) expression and intrauterine growth retardation (IUGR) with abnormal Umbilical artery flow velocity waveforms (UmA FVWS), and deduce the oxygen content in placental terminal villi.	Oxygen	233-239	vascular endothelial growth factor A	Homo sapiens	55-89
11372412-1	2000	OBJECTIVE: To study the relationship between placental vascular endothelial growth factor (VEGF) expression and intrauterine growth retardation (IUGR) with abnormal Umbilical artery flow velocity waveforms (UmA FVWS), and deduce the oxygen content in placental terminal villi.	Oxygen	233-239	vascular endothelial growth factor A	Homo sapiens	91-95
10995243-7	2000	An additional hydrogen-bond connects the syn G amino group to the 5" nonbridging pro-R(p) phosphate oxygen.	Oxygen	100-106	synergin gamma	Homo sapiens	41-46
11025195-2	2000	NO was found to increase the production of reactive oxygen species (ROS), the putative signaling molecules between a cellular O2-sensor and hypoxia inducible factor 1 (HIF-1).	Oxygen	126-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-166
11025195-2	2000	NO was found to increase the production of reactive oxygen species (ROS), the putative signaling molecules between a cellular O2-sensor and hypoxia inducible factor 1 (HIF-1).	Oxygen	126-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-173
11055378-2	2000	The main signal in the control of Epo production is oxygen; hypoxia stimulates Epo production through activation of Epo gene transcription.	Oxygen	52-58	erythropoietin	Homo sapiens	34-37
11055378-2	2000	The main signal in the control of Epo production is oxygen; hypoxia stimulates Epo production through activation of Epo gene transcription.	Oxygen	52-58	erythropoietin	Homo sapiens	79-82
11055378-2	2000	The main signal in the control of Epo production is oxygen; hypoxia stimulates Epo production through activation of Epo gene transcription.	Oxygen	52-58	erythropoietin	Homo sapiens	79-82
11002999-6	2000	In the reaction of 5 with O2 for example, the Et-B bonds remained intact, and the dimeric five-coordinate compound [Et2B(mu-pz)2 Al(mu-OEt)Et]2 (9) was isolated in good yield.	Oxygen	26-28	endothelin receptor type B	Homo sapiens	46-50
11052456-5	2000	Oxygen affinity of red cells was assessed by calculation of P50 (the PO2 at which hemoglobin is half saturated).	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	60-63
11020663-3	2000	This article reviews the current literature surrounding the potential role of NADPH oxidase in the oxygen sensing processes which underlie hypoxic pulmonary vasoconstriction, systemic vascular smooth muscle proliferation, carotid and airways chemoreceptor activation, erythropoietin gene expression, and oxytropic responses of plant cells.	Oxygen	99-105	erythropoietin	Homo sapiens	268-282
10837481-1	2000	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions (hypoxia).	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10837481-1	2000	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions (hypoxia).	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10837481-1	2000	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions (hypoxia).	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	88-122
10837481-1	2000	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions (hypoxia).	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	124-128
10837481-1	2000	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions (hypoxia).	Oxygen	156-162	erythropoietin	Homo sapiens	134-148
10837481-2	2000	VEGF is strongly induced at both the mRNA and protein expression level by a number of hormones and growth factors in vascular smooth muscle cells (VSMC) independently of the oxygen environment.	Oxygen	174-180	vascular endothelial growth factor A	Homo sapiens	0-4
10998766-9	2000	Peak oxygen uptake increased from baseline significantly during the first 6 months (from 29.6 +/- 5.7 to 30.6 +/- 6.3 ml.min-1.kg-1) and decreased to the baseline level (29.1 +/- 5.5 ml.min-1.kg-1) at 24 months.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	121-126
10998766-9	2000	Peak oxygen uptake increased from baseline significantly during the first 6 months (from 29.6 +/- 5.7 to 30.6 +/- 6.3 ml.min-1.kg-1) and decreased to the baseline level (29.1 +/- 5.5 ml.min-1.kg-1) at 24 months.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	186-191
10960492-1	2000	We hypothesized that reactive O2 species, or their intermediary products, generated during exposure to elevated O2 lead to pathologic endothelin-1 expression in the newborn lung.	Oxygen	30-32	endothelin 1	Rattus norvegicus	134-146
11320727-3	2000	Direct influence of oxygen on aerobes due to slow and limited enzyme inactivation (for example glutamate decarboxylase) and small number of affected "targets" is not responsible for total adverse effects of oxygen.	Oxygen	20-26	glutamate-ammonia ligase	Homo sapiens	95-118
10998176-10	2000	Two of these promoters, designated P3 and P4, are co-ordinately regulated with P1 and P2 in response to oxygen, ArcA and Fnr.	Oxygen	104-110	replication initiation protein	Escherichia coli	79-88
11125761-6	2000	RESULTS: Body mass-normalised maximal oxygen uptake of 58.0+/-4.9 ml x kg(-1) x min(-1) of the group is comparable to values reported in the literature for team game players.	Oxygen	38-44	CD59 molecule (CD59 blood group)	Homo sapiens	80-86
10960492-6	2000	We conclude that reactive O2 species, or their bioactive intermediaries, are causative in O2-mediated pulmonary hypertension and endothelin-1 up-regulation.	Oxygen	26-28	endothelin 1	Rattus norvegicus	129-141
10989603-0	2000	Differential activation of ERK 1/2 and JNK in normal human fibroblast-like cells in response to UVC radiation under different oxygen tensions.	Oxygen	126-132	mitogen-activated protein kinase 3	Homo sapiens	27-34
10951577-5	2000	Our results indicate that hypoxia (1.5% O2) increases mitochondrial ROS generation and increases p53 protein levels in human breast carcinoma MCF-7 cells and in normal human diploid fibroblast IMR-90 cells.	Oxygen	40-42	tumor protein p53	Homo sapiens	97-100
10989603-0	2000	Differential activation of ERK 1/2 and JNK in normal human fibroblast-like cells in response to UVC radiation under different oxygen tensions.	Oxygen	126-132	mitogen-activated protein kinase 8	Homo sapiens	39-42
10989603-8	2000	Furthermore, the balance between ERK1/2 and JNK activities after UV irradiation under different oxygen tensions possibly modified cellular outcome in response to UV.	Oxygen	96-102	mitogen-activated protein kinase 3	Homo sapiens	33-39
10989603-8	2000	Furthermore, the balance between ERK1/2 and JNK activities after UV irradiation under different oxygen tensions possibly modified cellular outcome in response to UV.	Oxygen	96-102	mitogen-activated protein kinase 8	Homo sapiens	44-47
11051565-0	2000	The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase.	Oxygen	53-59	nitric oxide synthase 2	Homo sapiens	63-84
11051565-1	2000	We have studied the reaction of reduced nitric-oxide synthase (NOS) with molecular oxygen at -30 degrees C. In the first reaction cycle (from L-Arg to hydroxy-L-Arg), an oxygen adduct complex formed rapidly.	Oxygen	83-89	nitric oxide synthase 2	Homo sapiens	40-61
11051565-1	2000	We have studied the reaction of reduced nitric-oxide synthase (NOS) with molecular oxygen at -30 degrees C. In the first reaction cycle (from L-Arg to hydroxy-L-Arg), an oxygen adduct complex formed rapidly.	Oxygen	170-176	nitric oxide synthase 2	Homo sapiens	40-61
10874132-11	2000	The rate of oxygen consumption decreased by 50% in the presence of 2000 U/mL of catalase.	Oxygen	12-18	catalase	Homo sapiens	80-88
10944113-2	2000	Here we show that the product of the von Hippel-Lindau (VHL) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of HIF-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of HIF-1 alpha.	Oxygen	213-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-149
10944113-2	2000	Here we show that the product of the von Hippel-Lindau (VHL) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of HIF-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of HIF-1 alpha.	Oxygen	213-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	252-263
10966111-0	2000	The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions.	Oxygen	53-55	ryanodine receptor 1	Homo sapiens	4-43
10861408-7	2000	Soybean peroxidase, which normally shows only classical peroxidase activity, was transformed into an oxygen-transfer catalyst when coimmobilized with glucose oxidase.	Oxygen	101-107	peroxidase	Glycine max	8-18
10861408-7	2000	Soybean peroxidase, which normally shows only classical peroxidase activity, was transformed into an oxygen-transfer catalyst when coimmobilized with glucose oxidase.	Oxygen	101-107	peroxidase	Glycine max	56-66
10924082-1	2000	Low oxygen (O(2)) is the key stimulus for expression of vascular endothelial growth factor (VEGF) in several adherent cells.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	56-90
10924049-6	2000	Bradykinin (10(-4) M)- or carbachol (CCh, 10(-4) M)-induced inhibition of O(2) consumption was impaired in diabetic tissues (51 +/- 6 vs. 17 +/- 4% or 48 +/- 4 vs. 19 +/- 3%, respectively, both P &lt; 0.05 compared with normal).	Oxygen	74-78	kininogen 1	Canis lupus familiaris	0-10
10924082-1	2000	Low oxygen (O(2)) is the key stimulus for expression of vascular endothelial growth factor (VEGF) in several adherent cells.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	92-96
10924082-1	2000	Low oxygen (O(2)) is the key stimulus for expression of vascular endothelial growth factor (VEGF) in several adherent cells.	Oxygen	12-16	vascular endothelial growth factor A	Homo sapiens	56-90
10924082-1	2000	Low oxygen (O(2)) is the key stimulus for expression of vascular endothelial growth factor (VEGF) in several adherent cells.	Oxygen	12-16	vascular endothelial growth factor A	Homo sapiens	92-96
10999643-1	2000	Unlike the brain, oxygen extraction for the heart is almost maximal at rest, so lowering coronary filling pressure (DBP) below the lower limit of autoregulation with antihypertensive drugs can lead to myocardial ischemia.	Oxygen	18-24	D-box binding PAR bZIP transcription factor	Homo sapiens	116-119
10905409-6	2000	Oxygen availability was modified by changing the immobilized catalase concentration (0-15 units catalase per unit glucose oxidase) and by bubbling oxygen through the medium.	Oxygen	0-6	catalase	Rattus norvegicus	61-69
10905409-6	2000	Oxygen availability was modified by changing the immobilized catalase concentration (0-15 units catalase per unit glucose oxidase) and by bubbling oxygen through the medium.	Oxygen	0-6	catalase	Rattus norvegicus	96-104
10971400-3	2000	NO gas in air shifts the oxygen affinity, as measured by P50 to the left.	Oxygen	25-31	nuclear factor kappa B subunit 1	Homo sapiens	57-60
10850856-5	2000	However, when BAL cells were exposed to LPS in vitro, TNF-alpha production was higher in cells from rats exposed to 95% oxygen compared to cells from rats exposed to ambient air.	Oxygen	120-126	tumor necrosis factor	Rattus norvegicus	54-63
10987187-7	2000	Cytochrome P450 (CYP)-dependent 7-ethoxycoumarin O-deethylation (ECOD) did not differ between the various O2 concentrations, but declined from 2 to 48 hrs of incubation.	Oxygen	106-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
10966238-1	2000	OBJECTIVE: To test the effect of a continuous infusion of the nitric oxide (NO) synthase (S) inhibitor aminoethyl-isothiourea (AE-ITU) on survival time, hemodynamics, and oxygen transport in a porcine model of live group A streptococcal (GAS) sepsis.	Oxygen	171-177	nitric oxide synthase 2	Sus scrofa	62-88
10850856-6	2000	In addition, lung TNF-alpha and IL-6 mRNA levels were increased after exposure to 95% oxygen.	Oxygen	86-92	tumor necrosis factor	Rattus norvegicus	18-27
10850856-6	2000	In addition, lung TNF-alpha and IL-6 mRNA levels were increased after exposure to 95% oxygen.	Oxygen	86-92	interleukin 6	Rattus norvegicus	32-36
10942168-10	2000	In conclusion, short-term administration of simvastatin in rats potentiates the ability of angiotensin-converting enzyme (ACE) inhibitors and amlodipine to cause NO-mediated regulation of MV(O2).	Oxygen	191-193	angiotensin I converting enzyme	Rattus norvegicus	91-120
10906152-14	2000	These data provide evidence that AngII- mediated oxygen stress leads to the phosphorylation of p44/42 MAP kinase in proximal tubular cells.	Oxygen	49-55	angiotensinogen	Homo sapiens	33-38
10942168-10	2000	In conclusion, short-term administration of simvastatin in rats potentiates the ability of angiotensin-converting enzyme (ACE) inhibitors and amlodipine to cause NO-mediated regulation of MV(O2).	Oxygen	191-193	angiotensin I converting enzyme	Rattus norvegicus	122-125
10828388-6	2000	The paper presents a thermodynamic consideration and comparative analysis of PCB decomposition processes in air or argon (+oxygen) thermal plasmas.	Oxygen	123-129	pyruvate carboxylase	Homo sapiens	77-80
10947166-0	2000	Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.	Oxygen	29-35	interleukin-1 beta	Oryctolagus cuniculus	0-17
10900169-1	2000	Modulation of the biosynthesis of the vasoconstrictor peptide endothelin-1 by oxygen-derived free radicals generated by xanthine oxidase or hydrogen peroxide was studied in cultured endothelial cells.	Oxygen	78-84	endothelin 1	Homo sapiens	62-74
10922063-3	2000	HIF-1alpha, and its relatives HIF-2alpha/endothelial PAS domain protein (EPAS) and HIF-3alpha, are induced in response to hypoxia and serve to coordinately activate the expression of target genes whose products facilitate cell survival under conditions of oxygen deprivation.	Oxygen	256-262	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
10922063-3	2000	HIF-1alpha, and its relatives HIF-2alpha/endothelial PAS domain protein (EPAS) and HIF-3alpha, are induced in response to hypoxia and serve to coordinately activate the expression of target genes whose products facilitate cell survival under conditions of oxygen deprivation.	Oxygen	256-262	hypoxia inducible factor 3 subunit alpha	Homo sapiens	83-93
10947166-0	2000	Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.	Oxygen	45-51	interleukin-1 beta	Oryctolagus cuniculus	0-17
10947166-11	2000	These results indicate that IL-1beta impairs systemic oxygen uptake even before VO2 becomes supply-dependent, presumably due to maldistribution of the blood flow including the splanchnic circulation.	Oxygen	54-60	interleukin-1 beta	Oryctolagus cuniculus	28-36
10878378-6	2000	Our results indicate that hypoxia (1.5% O2) stimulates NF-kappa B and TNF-alpha gene transcription and increases ROS generation as measured by the oxidant sensitive dye 2",7"-dichlorofluorescein diacetate in murine macrophage J774.1 cells.	Oxygen	40-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-65
10878378-6	2000	Our results indicate that hypoxia (1.5% O2) stimulates NF-kappa B and TNF-alpha gene transcription and increases ROS generation as measured by the oxidant sensitive dye 2",7"-dichlorofluorescein diacetate in murine macrophage J774.1 cells.	Oxygen	40-42	tumor necrosis factor	Mus musculus	70-79
10801793-2	2000	The O(2) and redox-sensitive transcription factors hypoxia inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappaB (NF-kappaB) are differentially regulated in the alveolar epithelium over fetal to neonatal oxygen tensions.	Oxygen	213-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-82
10801793-2	2000	The O(2) and redox-sensitive transcription factors hypoxia inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappaB (NF-kappaB) are differentially regulated in the alveolar epithelium over fetal to neonatal oxygen tensions.	Oxygen	213-219	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
10913623-0	2000	Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension.	Oxygen	69-75	nitric oxide synthase 2	Rattus norvegicus	14-18
10913623-2	2000	We hypothesized that O(2) tension may regulate iNOS expression in rat liver through the production of reactive oxygen species (ROS) and the reduction of intracellular glutathione (GSH) levels.	Oxygen	21-25	nitric oxide synthase 2	Rattus norvegicus	47-51
10913623-5	2000	We found that 95% O(2) tension caused a significant induction of the iNOS protein and mRNA levels paralleled by a significant fall in intracellular GSH concentration.	Oxygen	18-22	nitric oxide synthase 2	Rattus norvegicus	69-73
10913623-7	2000	These results indicate that molecular O(2) regulates the expression of iNOS in rat liver at the transcriptional level, most likely through the production of ROS and the reduction of intracellular GSH levels.	Oxygen	38-42	nitric oxide synthase 2	Rattus norvegicus	71-75
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	tumor necrosis factor	Homo sapiens	23-32
10873905-3	2000	Profound alkalemia may impair oxygen delivery because of stronger hemoglobin-oxygen affinity, vasoconstriction, and alterations in the redox potential of cytochrome c.	Oxygen	30-36	cytochrome c, somatic	Homo sapiens	154-166
10903049-3	2000	Supplemental bFGF increased vascularity in nonirradiated flaps by 80% (p = .005), with a trend to a higher tissue oxygen level by day 14.	Oxygen	114-120	fibroblast growth factor 2	Homo sapiens	13-17
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	interleukin 6	Homo sapiens	58-62
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	interleukin 1 beta	Homo sapiens	67-75
10933830-4	2000	Super broth medium, a low post-induction temperature (30 degrees C), and a glucose feed based on dissolved oxygen resulted in high lpp-DBP yield and minimized apoprotein formation.	Oxygen	107-113	Dbp	Escherichia coli	135-138
10878565-0	2000	Simultaneous recording of calcium transients and reactive oxygen intermediates of human polymorphonuclear granulocytes in response to formyl-Met-Leu-Phe and the environmental agent sulfite.	Oxygen	58-64	formyl peptide receptor 1	Homo sapiens	134-152
10893358-1	2000	STUDY OBJECTIVES: To investigate the hypothesis that an increase in circulating vascular endothelial growth factor (VEGF) occurs in mountaineers at high altitude, particularly in association with acute mountain sickness (AMS) and/or low hemoglobin oxygen saturation.	Oxygen	248-254	vascular endothelial growth factor A	Homo sapiens	80-114
10893358-1	2000	STUDY OBJECTIVES: To investigate the hypothesis that an increase in circulating vascular endothelial growth factor (VEGF) occurs in mountaineers at high altitude, particularly in association with acute mountain sickness (AMS) and/or low hemoglobin oxygen saturation.	Oxygen	248-254	vascular endothelial growth factor A	Homo sapiens	116-120
10880232-5	2000	Aphidicolin also synergized with TNF and anti-Fas in inducing cell death which was prevented by reducing atmospheric oxygen or addition of n -acetyl cysteine, a scavenger of oxygen radicals.	Oxygen	117-123	tumor necrosis factor	Homo sapiens	33-36
10877840-3	2000	Lipoxygenases are enzymes that, as cyclooxygenases (COX), can insert oxygen into the molecule of arachidonic acid and thereby synthesize inflammatory eicosanoids: leukotrienes [due to 5-lipoxygenase (5-LOX) activity] and prostaglandins (via COX activity).	Oxygen	3-9	arachidonate 5-lipoxygenase	Homo sapiens	184-198
10909962-0	2000	Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.	Oxygen	144-146	insulin	Homo sapiens	42-49
10958374-4	2000	The subjects" oxygen consumption values ranged from 0.14 to 1.19 l x min(-1).	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	69-75
10907637-1	2000	OBJECTIVE: Future prospects for gene therapy of chronic anemias involve expression of the erythropoietin transgene, which is regulated by oxygen tension.	Oxygen	138-144	erythropoietin	Homo sapiens	90-104
10909962-6	2000	In the entire group, exercise increased oxygen consumption from 2.3 +/- 0.3 ml x kg(-1) muscle x min(-1) (insulin) to 34.2 +/- 3. ml x kg(-1) muscle x min(-1) (insulin and exercise) (P &lt; 0.001) and muscle glucose uptake from 60 +/- 6 pmol x kg(-1) muscle x min(-1) (insulin) to 220 +/- 22 micromol x kg(-1) muscle x min(-1) (insulin and exercise) (P &lt; 0.001).	Oxygen	40-46	insulin	Homo sapiens	106-113
10909968-6	2000	This increased toxicity of the cytokine mixture compared with that of IL-1beta alone could be explained by a higher rate of NO generation within the early 24-48 h incubation period that would favor the toxic synergism of NO and oxygen free radicals.	Oxygen	228-234	interleukin 1 beta	Rattus norvegicus	70-78
10907637-7	2000	CONCLUSION: These results show that, in addition to oxygen partial pressure, the intracellular iron content is critical in the modulation of hypoxia-regulated erythropoietin transgene expression.	Oxygen	52-58	erythropoietin	Homo sapiens	159-173
10959032-3	2000	Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry.	Oxygen	25-31	amyloid beta precursor protein	Homo sapiens	0-5
11758972-3	2000	Gadd153 mRNA content was increased in PASMCs cultured for 24 hours in 1% oxygen.	Oxygen	73-79	DNA damage inducible transcript 3	Homo sapiens	0-7
10898620-4	2000	D-Glucose showed a higher level of reactivity with the amino groups of LZM than D-fructose, both in the presence and in the absence of oxygen.	Oxygen	135-141	lysozyme	Homo sapiens	71-74
10898620-6	2000	The more reactive glycoxidation products formed during the initial stages of incubation in the presence of oxygen accelerated the rate of glycation during the later stages of incubation and increased the involvement of arginine residues of LZM in the glycation reaction.	Oxygen	107-113	lysozyme	Homo sapiens	240-243
10898620-9	2000	The effect of oxygen-induced glycoxidation on the glycation reaction was also more pronounced in the LZM-G system compared with that in the LZM-F system.	Oxygen	14-20	lysozyme	Homo sapiens	101-104
10898620-9	2000	The effect of oxygen-induced glycoxidation on the glycation reaction was also more pronounced in the LZM-G system compared with that in the LZM-F system.	Oxygen	14-20	lysozyme	Homo sapiens	140-143
10742562-1	2000	Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage.	Oxygen	69-75	myeloperoxidase	Homo sapiens	0-15
10742562-1	2000	Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage.	Oxygen	69-75	myeloperoxidase	Homo sapiens	17-20
10923785-4	2000	We constructed a refolding procedure of high lysozyme concentration (0.5-10 mg/ml) based on the linear reduction of the urea concentration during diafiltration under oxygen pressure.	Oxygen	166-172	lysozyme	Homo sapiens	45-53
10886548-11	2000	Stimulation of VEGF synthesis at low O2 tension and following IL-1beta treatment was detectable at the protein level only.	Oxygen	37-39	vascular endothelial growth factor A	Homo sapiens	15-19
10965376-6	2000	Measurements of maximal oxygen uptake before the start of the training (15 mL min-1 kg-1) revealed a level close to the presumed limit for independent living (13 mL min-1 kg-1).	Oxygen	24-30	CD59 molecule (CD59 blood group)	Homo sapiens	78-88
10873592-1	2000	The Hypoxia-Inducible Factor-1 (HIF-1) activates the transcription of many genes required for cellular and organismal responses to oxygen deprivation.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
10873592-1	2000	The Hypoxia-Inducible Factor-1 (HIF-1) activates the transcription of many genes required for cellular and organismal responses to oxygen deprivation.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
10873592-3	2000	ARNT2 is a conserved ARNT homolog that is highly expressed in neurons, suggesting that ARNT2/HIF-1alpha heterodimers mediate transcriptional responses to oxygen deprivation in the nervous system.	Oxygen	154-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-103
11196992-4	2000	The same reaction under an oxygen atmosphere initiates the cobalt-bromide-catalyzed oxidation of benzyl bromide, thus leading to the regeneration of inorganic bromide and the fast reduction of Co(III).	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	193-200
10799243-3	2000	Since nitric oxide (NO), the product of the action of iNOS on molecular oxygen and l-arginine, produces vasodilation and decreases platelet aggregation, we believe it is an integral part of the initial detrusor response to obstruction.	Oxygen	72-78	nitric oxide synthase 2, inducible	Mus musculus	54-58
10829093-7	2000	In this chain of reactions the vasoconstrictor effects derived from oxygen quenching of nitric oxide and increased isoprostane synthesis could explain how hypertension is maintained with normal plasma levels of renin.	Oxygen	68-74	renin	Homo sapiens	211-216
10751700-1	2000	This study was carried out to investigate the role of endogenous endothelins in intestinal motility following bum injury by using a nonselective endothelin-1 (ET-1) antagonist and to evaluate the ET-1-mediated reactive oxygen metabolite formation and neutrophil infiltration following burn injury.	Oxygen	219-225	endothelin 1	Homo sapiens	196-200
10875461-10	2000	Oxygen-derived free radicals and many cytokines (e.g., interleukin [IL]-1, IL-6, IL-8, tumor necrosis factor-alpha, platelet activating factor) are considered to be principal mediators in the transformation of acute pancreatitis from a local inflammatory process into a multiorgan illness.	Oxygen	0-6	interleukin 6	Homo sapiens	75-79
10875461-10	2000	Oxygen-derived free radicals and many cytokines (e.g., interleukin [IL]-1, IL-6, IL-8, tumor necrosis factor-alpha, platelet activating factor) are considered to be principal mediators in the transformation of acute pancreatitis from a local inflammatory process into a multiorgan illness.	Oxygen	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
10875461-10	2000	Oxygen-derived free radicals and many cytokines (e.g., interleukin [IL]-1, IL-6, IL-8, tumor necrosis factor-alpha, platelet activating factor) are considered to be principal mediators in the transformation of acute pancreatitis from a local inflammatory process into a multiorgan illness.	Oxygen	0-6	tumor necrosis factor	Homo sapiens	87-114
10811871-3	2000	This suggests that reduced oxygen tension can promote angiogenesis not only by stimulating the production of inducers, such as vascular endothelial growth factor, but also by reducing the production of inhibitors.	Oxygen	27-33	vascular endothelial growth factor A	Homo sapiens	127-161
10847587-0	2000	Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10948844-1	2000	Although chronic sympathetic activation provides inotropic and chronotropic support to the failing heart, such activation may also have deleterious effects, including the direct cardiotoxic effects of catecholamines, activation of the renin-angiotensin-aldosterone system and an increase in myocardial oxygen demand.	Oxygen	302-308	renin	Homo sapiens	235-240
10883739-7	2000	ET-1 release was increased by oxygen and reduced by pyrogens (endotoxin and IL-1, both at 100 ng mL(-1)).	Oxygen	30-36	endothelin 1	Homo sapiens	0-4
10883739-9	2000	We conclude that ET-1 is formed naturally in the ductus and that its formation may change in response to physiological (oxygen) and pathophysiological (pyrogens) stimuli.	Oxygen	120-126	endothelin 1	Homo sapiens	17-21
11305808-0	2000	Optimal hematocrit for the maximum oxygen delivery to the brain with recombinant human erythropoietin in hemodialysis patients.	Oxygen	35-41	erythropoietin	Homo sapiens	87-101
10811605-9	2000	In Chlamydomonas, Crd1 expression is activated in copper- or oxygen-deficient cells, and Crd1 function is required for adaptation to these conditions.	Oxygen	61-67	uncharacterized protein	Chlamydomonas reinhardtii	18-22
10952418-4	2000	Endothelin-1 levels correlate inversely with maximum oxygen consumption, and inhibition of the myocardial endothelin pathway in rats with CHF improves survival.	Oxygen	53-59	endothelin 1	Rattus norvegicus	0-12
10847180-0	2000	Temporal and small-scale spatial variations of dissolved oxygen in the Rivers Thames, Pang and Kennet, UK.	Oxygen	57-63	contactin 3	Homo sapiens	86-90
10781441-2	2000	The cytokine tumor necrosis factor (TNF)-alpha is induced in lungs exposed to high concentrations of oxygen; however, its contribution to hyperoxia-induced lung injury remains unclear.	Oxygen	101-107	tumor necrosis factor	Mus musculus	13-46
10844830-0	2000	Inspired oxygen fraction after cardiopulmonary bypass: effects on pulmonary function with regard to endothelin-1 concentrations and venous admixture.	Oxygen	9-15	endothelin 1	Homo sapiens	100-112
10844831-3	2000	Cardiac output and systemic oxygen consumption increased from 2.83 (0.68) litres min-1 m-2 to 3.17 (0.57) litres min-1 m-2 and from 126 (18) ml min-1 m-2 to 135 (44) ml min-1 m-2, respectively (mean (SD), P = 0.028 and P = 0.019, respectively, baseline vs 6 h).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
10844831-3	2000	Cardiac output and systemic oxygen consumption increased from 2.83 (0.68) litres min-1 m-2 to 3.17 (0.57) litres min-1 m-2 and from 126 (18) ml min-1 m-2 to 135 (44) ml min-1 m-2, respectively (mean (SD), P = 0.028 and P = 0.019, respectively, baseline vs 6 h).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
10844831-3	2000	Cardiac output and systemic oxygen consumption increased from 2.83 (0.68) litres min-1 m-2 to 3.17 (0.57) litres min-1 m-2 and from 126 (18) ml min-1 m-2 to 135 (44) ml min-1 m-2, respectively (mean (SD), P = 0.028 and P = 0.019, respectively, baseline vs 6 h).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
10844831-3	2000	Cardiac output and systemic oxygen consumption increased from 2.83 (0.68) litres min-1 m-2 to 3.17 (0.57) litres min-1 m-2 and from 126 (18) ml min-1 m-2 to 135 (44) ml min-1 m-2, respectively (mean (SD), P = 0.028 and P = 0.019, respectively, baseline vs 6 h).	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
10768942-2	2000	The macrophage (Mphi) represents the major cell defense against this pathogen; when activated with gamma interferon (IFN-gamma), murine Mphis kill the fungus by an oxygen-independent mechanism.	Oxygen	164-170	interferon gamma	Mus musculus	99-126
10892391-9	2000	Pulmonary TNF alpha was produced early on O2 exposure (day 3) and pulmonary IL-6 later (days 6 and 9).	Oxygen	42-44	tumor necrosis factor	Rattus norvegicus	10-19
10798670-3	2000	METHODS: OIR was induced in C57BL6 mice by a 5-day exposure to 75% oxygen from postnatal day (P)7 through P12.	Oxygen	67-73	polymerase (DNA-directed), delta 4	Mus musculus	106-109
10788812-6	2000	On postoperative day 5, oxygenation was significantly improved in grafts transfected with the transforming growth factor-beta1 sense construct compared with antisense controls (arterial oxygen tension = 411 +/- 198 vs 103 +/- 85 mm Hg, respectively; P =.002).	Oxygen	24-30	transforming growth factor, beta 1	Rattus norvegicus	94-126
10800947-0	2000	Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.	Oxygen	84-90	nitric oxide synthase 2	Rattus norvegicus	46-77
10800947-4	2000	We therefore decided to investigate whether glutamate, which is released in ischemia and is implicated in neurotoxicity, might be involved in the mechanisms by which oxygen and glucose deprivation (OGD) leads to the expression of iNOS in rat forebrain slices.	Oxygen	166-172	nitric oxide synthase 2	Rattus norvegicus	230-234
10817412-9	2000	For the 4 lifts, values (mean +/- SD) varied from 20.3 +/- 5.4 to 28.8 +/- 5.8 mL x kg x min(-1) for oxygen uptake, 42.2 +/- 11.1 to 66.4 +/- 15.2 L x min(-2) for minute ventilation,129 +/- 20.6 to 156 +/- 16.5 beats x min(-1) for heart rate, 5.8 +/- 1.6 to 8.2 +/- 1.6 for metabolic equivalent, and 197 +/- 49.4 to 245 +/- 41.2 for rate-pressure product (x10(-2)).	Oxygen	101-107	CD59 molecule (CD59 blood group)	Homo sapiens	89-95
10813371-0	2000	Oxygen radical system in chronic infarcted rat heart: the effect of combined beta blockade and ACE inhibition.	Oxygen	0-6	angiotensin I converting enzyme	Rattus norvegicus	95-98
10790158-12	2000	These findings show that the KO2 channel in PC12 cells belongs to the Kv1 subfamily of K+ channels and that the Kv1.2 alpha-subunit is important in conferring O2 sensitivity to this channel.	Oxygen	30-32	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	112-117
10889449-3	2000	In the presence of the oxygen free radical spin trapping reagent, 5,5-dimethyl pyrroline-N-oxide (DMPO), the induction of MnSOD gene expression by TNF-alpha was significantly reduced.	Oxygen	23-29	tumor necrosis factor	Homo sapiens	147-156
10795782-1	2000	PURPOSE: The majority of highly trained endurance athletes with a maximal oxygen uptake greater than 60 mL x min(-1) x kg(-1) develop exercise-induced hypoxemia (EIH).	Oxygen	74-80	CD59 molecule (CD59 blood group)	Homo sapiens	109-115
10773416-2	2000	The differences in gene expressions of Bcl-2, TRX and CO III mRNA between SHRSP and WKY were most remarkable at 30 min of oxygen stimulation, and the expressions of these genes were significantly lower in SHRSP compared with those in WKY.	Oxygen	122-128	BCL2, apoptosis regulator	Rattus norvegicus	39-44
10773416-2	2000	The differences in gene expressions of Bcl-2, TRX and CO III mRNA between SHRSP and WKY were most remarkable at 30 min of oxygen stimulation, and the expressions of these genes were significantly lower in SHRSP compared with those in WKY.	Oxygen	122-128	thioredoxin 1	Rattus norvegicus	46-49
10758161-0	2000	Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
10758161-1	2000	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O(2) availability in mammals, including angiogenesis, erythropoiesis, and glycolysis.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10758161-1	2000	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O(2) availability in mammals, including angiogenesis, erythropoiesis, and glycolysis.	Oxygen	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10907785-8	2000	The oxidative inactivation of PKC, particularly its activated form that translocated to the membrane fraction, was confirmed in the in vitro exposure to active oxygen generators at an optimal concentration; this inactivation was prevented by catalase and superoxide dismutase.	Oxygen	160-166	catalase	Rattus norvegicus	242-250
10766820-3	2000	Such tissue factor expression in an oxygen deficient environment is driven by the transcription factor Early Growth Response (Egr)-1.	Oxygen	36-42	coagulation factor III	Mus musculus	5-18
10677352-17	2000	Most importantly, incubation of apo A-I with the myeloperoxidase/H(2)O(2)/Cl(-) system (the source of HOCl in vivo) resulted in almost identical modification patterns to those observed with reagent NaOCl.	Oxygen	69-73	myeloperoxidase	Homo sapiens	49-64
10759582-7	2000	The maximal oxygen uptake of skeletal muscle is around 300-400 mL min-1 kg-1.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	66-76
10759582-8	2000	This uptake rate corresponds to a TCA cycle rate of 4-5 mmol min-1 kg-1, which is of the same magnitude as the activity of oxyglutarate dehydrogenase and pyruvate dehydrogenase, suggesting that these enzymes may be rate limiting for oxygen uptake when an isolated muscle is exercising.	Oxygen	233-239	CD59 molecule (CD59 blood group)	Homo sapiens	61-71
10711978-4	2000	Mean values for the directly measured oxygen uptake ranged for all trials from 0.5 to 2.1 l O2 min(-1), and analysis of variance showed significant differences regarding slope, load carried, and symmetry.	Oxygen	38-44	CD59 molecule (CD59 blood group)	Homo sapiens	95-101
10711978-5	2000	The calculated values of oxygen uptake based on the biomechanical model correlated significantly with the directly measured values, fitting to the line Y = 0.990 X + 0.144, where Y is the estimated and X is the measured oxygen uptake in l min(-1).	Oxygen	25-31	CD59 molecule (CD59 blood group)	Homo sapiens	239-245
10711978-5	2000	The calculated values of oxygen uptake based on the biomechanical model correlated significantly with the directly measured values, fitting to the line Y = 0.990 X + 0.144, where Y is the estimated and X is the measured oxygen uptake in l min(-1).	Oxygen	220-226	CD59 molecule (CD59 blood group)	Homo sapiens	239-245
12937606-8	2000	It consists of connective tissue cells: fibroblasts, macrophages and proliferating endothelial cells forming microvessels under the control of angiogenic growth factors: bFGF, VEGF and angiopoietins, which all promote angiogenesiscapillary vessel formation, essential for the restoration of microvascular network in the mucosa and thus crucial for oxygen and nutrient supply.	Oxygen	348-354	fibroblast growth factor 2	Homo sapiens	170-174
10776998-9	2000	In addition, we found a positive correlation between serum IGF-I levels and oxygen saturation of the patients (r=0.402, p&lt;0.05).	Oxygen	76-82	insulin like growth factor 1	Homo sapiens	59-64
10713080-8	2000	The up-regulation of monocyte-derived reactive oxygen by oxAAT could potentially result in self-amplification of AAT oxidation and, thereby, the other effects deriving from it.	Oxygen	47-53	serpin family A member 1	Homo sapiens	59-62
10932813-4	2000	Seven weeks of injection with recombinant human erythropoietin (rhEPO) (20-40 IU per kg body weight) increased [Hb] and Hct, maximal oxygen uptake (VO2max) and physical performance were increased.	Oxygen	133-139	erythropoietin	Homo sapiens	48-62
10758927-6	2000	Pure oxygen administration significantly decreased adenosine and beta-endorphin levels, much more so in patients with COPD and PPH.	Oxygen	5-11	proopiomelanocortin	Homo sapiens	65-79
10751333-5	2000	In this study, we hypothesized that the hypoxic regulation of VEGF expression by osteoblasts occurs via an oxygen-sensing mechanism similar to the regulation of the erythropoietin gene (EPO).	Oxygen	107-113	vascular endothelial growth factor A	Homo sapiens	62-66
10751333-6	2000	To test this hypothesis, we examined the kinetics of oxygen concentration on osteoblast VEGF expression.	Oxygen	53-59	vascular endothelial growth factor A	Homo sapiens	88-92
10751333-7	2000	In addition, we analyzed the effects of nickel and cobalt on the expression of VEGF in osteoblastic cells because these metallic ions mimic hypoxia by binding to the heme portion of oxygen-sensing molecules.	Oxygen	182-188	vascular endothelial growth factor A	Homo sapiens	79-83
10751333-9	2000	In addition, we found that nickel and cobalt both stimulate VEGF gene expression in a similar time- and dose-dependent manner, suggesting the presence of a hemelike oxygen-sensing mechanism similar to that of the EPO gene.	Oxygen	165-171	vascular endothelial growth factor A	Homo sapiens	60-64
10751333-11	2000	These studies demonstrate that hypoxia, nickel, and cobalt regulate VEGF expression in osteoblasts via a similar mechanism, implicating the involvement of a heme-containing oxygen-sensing molecule.	Oxygen	173-179	vascular endothelial growth factor A	Homo sapiens	68-72
10807515-1	2000	By comparing the hepatic responses to tumor necrosis factor (TNF)-alpha that occur during situations that promote liver injury (such as obesity or chronic exposure to ethanol) with those that occur after stimuli (such as partial hepatectomy) that lead to liver regeneration, it is apparent that hepatocytes are usually able to constrain noxious responses to TNF-alpha, such as the release of reactive oxygen from mitochondria.	Oxygen	401-407	tumor necrosis factor	Homo sapiens	38-71
10782904-0	2000	Oxygen regulation of rat hepatocyte iNOS gene expression.	Oxygen	0-6	nitric oxide synthase 2	Rattus norvegicus	36-40
10782904-2	2000	The aim of this study was to see whether iNOS gene expression is triggered by oxygen tension in rat hepatocytes exposed in vivo to high (periportal) and low (perivenous) oxygen tension.	Oxygen	78-84	nitric oxide synthase 2	Rattus norvegicus	41-45
10782904-2	2000	The aim of this study was to see whether iNOS gene expression is triggered by oxygen tension in rat hepatocytes exposed in vivo to high (periportal) and low (perivenous) oxygen tension.	Oxygen	170-176	nitric oxide synthase 2	Rattus norvegicus	41-45
10782904-8	2000	Transfection experiments showed that the expression of chloramphenicol acetyltransferase driven by iNOS promoter was increased in cells maintained at low oxygen tension.	Oxygen	154-160	nitric oxide synthase 2	Rattus norvegicus	99-103
10782904-9	2000	CONCLUSIONS: Our experiments show that in rat hepatocytes: 1) iNOS is induced by low oxygen tension; 2) the modification occurs at the transcriptional level; 3) the enzyme at 5% oxygen is able to catalyze the synthesis of NO, although no nitrites are accumulated in the medium.	Oxygen	85-91	nitric oxide synthase 2	Rattus norvegicus	62-66
10782904-9	2000	CONCLUSIONS: Our experiments show that in rat hepatocytes: 1) iNOS is induced by low oxygen tension; 2) the modification occurs at the transcriptional level; 3) the enzyme at 5% oxygen is able to catalyze the synthesis of NO, although no nitrites are accumulated in the medium.	Oxygen	178-184	nitric oxide synthase 2	Rattus norvegicus	62-66
10744228-0	2000	Effect of hyperbaric oxygen on neutrophil CD18 expression.	Oxygen	21-27	integrin subunit beta 2	Rattus norvegicus	42-46
10744228-3	2000	The purpose of this study was to evaluate the effect of hyperbaric oxygen on neutrophil CD18 adhesion sites by flow cytometry in an animal model of ischemia-reperfusion injury.	Oxygen	67-73	integrin subunit beta 2	Rattus norvegicus	88-92
10694440-5	2000	Transient transfections using a luciferase reporter construct containing 2 kbp of the mouse uPAR promoter showed that promoter activity increased up to 5-fold after exposure to 0.2% oxygen.	Oxygen	182-188	plasminogen activator, urokinase receptor	Mus musculus	92-96
10729748-6	2000	In the remnant-kidney model, catalase seems to be more vulnerable to reactive oxygen intermediates than superoxide dismutase and glutathione peroxidase.	Oxygen	78-84	catalase	Rattus norvegicus	29-37
10720691-6	2000	Also, total, CD15(bright)/CD11b(-) (promyelocytes, early myelocytes), and CD15(bright)/CD11b(+) cell expansion was enhanced at lower pO(2), with twice as many of each cell type produced at 5% O(2) as at 20% O(2).	Oxygen	134-138	fucosyltransferase 4	Homo sapiens	13-17
10720691-6	2000	Also, total, CD15(bright)/CD11b(-) (promyelocytes, early myelocytes), and CD15(bright)/CD11b(+) cell expansion was enhanced at lower pO(2), with twice as many of each cell type produced at 5% O(2) as at 20% O(2).	Oxygen	134-138	fucosyltransferase 4	Homo sapiens	74-78
10720691-7	2000	The effects of low pH and low pO(2) were additive, such that generation of total, CD15(bright)/CD11b(-), and CD15(bright)/CD11b(+) cells was 3.5-, 2.4-, and 4.0-fold greater at pH 7.21 and 5% O(2) than at the standard hematopoietic culture conditions of pH 7.38 and 20% O(2).	Oxygen	31-35	fucosyltransferase 4	Homo sapiens	82-86
10757022-3	2000	Constructs with five copies of hypoxia-responsive elements (HREs) derived from the 5"-untranslated region (UTR) of the human VEGF showed excellent transcriptional activation at low oxygen tension relevant to tumor hypoxia.	Oxygen	181-187	vascular endothelial growth factor A	Homo sapiens	125-129
10720691-7	2000	The effects of low pH and low pO(2) were additive, such that generation of total, CD15(bright)/CD11b(-), and CD15(bright)/CD11b(+) cells was 3.5-, 2.4-, and 4.0-fold greater at pH 7.21 and 5% O(2) than at the standard hematopoietic culture conditions of pH 7.38 and 20% O(2).	Oxygen	31-35	fucosyltransferase 4	Homo sapiens	109-113
10706580-7	2000	Vasopressin resulted in increased oxygen consumption but no change in triglyceride hydrolysis.	Oxygen	34-40	arginine vasopressin	Rattus norvegicus	0-11
10712429-0	2000	Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10712429-9	2000	These data suggest that the oxygen-regulated early events of trophoblast differentiation are in part mediated by TGFbeta(3) through HIF-1 transcription factors.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-137
10831117-0	2000	Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.	Oxygen	121-127	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	94-98
10752318-1	2000	The position of oxyhemoglobin dissociation curve (ODC) expressed with P50, has a large influence on the oxygen supply.	Oxygen	104-110	nuclear factor kappa B subunit 1	Homo sapiens	70-73
10752318-2	2000	It has been reported that during hypoxia with increased oxygen demand, P50 can increase with a reduction in oxygen affinity.	Oxygen	56-62	nuclear factor kappa B subunit 1	Homo sapiens	71-74
10752318-2	2000	It has been reported that during hypoxia with increased oxygen demand, P50 can increase with a reduction in oxygen affinity.	Oxygen	108-114	nuclear factor kappa B subunit 1	Homo sapiens	71-74
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Oxygen	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Oxygen	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10760139-10	2000	This simple example of protein engineering, converting an oxygen-labile [4Fe 4S] containing FNR-like protein into a dithiol-disulphide FLP-like redox sensor demonstrates the versatility of the basic CRP structure.	Oxygen	58-64	flp	Lactococcus lactis	135-138
10831117-0	2000	Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.	Oxygen	121-127	fms related receptor tyrosine kinase 1	Homo sapiens	112-117
10831117-2	2000	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) expression and function.	Oxygen	50-56	vascular endothelial growth factor A	Homo sapiens	164-198
10831117-2	2000	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) expression and function.	Oxygen	50-56	vascular endothelial growth factor A	Homo sapiens	200-204
10831117-2	2000	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) expression and function.	Oxygen	50-56	placental growth factor	Homo sapiens	210-232
10657030-0	2000	Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species.	Oxygen	137-143	BCL2 apoptosis regulator	Homo sapiens	0-5
10831117-2	2000	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) expression and function.	Oxygen	50-56	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	234-238
10831117-6	2000	Levels of soluble Flt-1 (sFlt-1) protein in supernatant of term villous explants were upregulated by 1 per cent hypoxia, whereas hyperoxia (40 per cent) decreased sFlt-1 levels, indicating that under conditions of increasing oxygen tension, PlGF function may remain unopposed.	Oxygen	225-231	fms related receptor tyrosine kinase 1	Homo sapiens	18-23
10831118-4	2000	In other mammalian systems, oxygen tension effects are mediated by hypoxia inducible factor-1 (HIF-1).	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-93
10831118-4	2000	In other mammalian systems, oxygen tension effects are mediated by hypoxia inducible factor-1 (HIF-1).	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-100
10681455-7	2000	In contrast, 50 nM (10 units/ml) thrombin decreased further the reduced neuronal survival that follows the deprivation of oxygen and glucose, and 500 nM even caused neuronal cell death by itself.	Oxygen	122-128	coagulation factor II	Rattus norvegicus	33-41
11186723-3	2000	If catalase is present in the lavage fluid (this enzyme is present in erythrocytes, leukocytes, and bacteria), hydrogen peroxide is degraded and oxygen is released.	Oxygen	145-151	catalase	Homo sapiens	3-11
10679271-4	2000	In addition, gliotoxin made neutrophils reduce cytochrome c regardless of absence of PMA, through its reaction with intracellular reductants in an oxygen-dependent process, named redox cycling.	Oxygen	147-153	cytochrome c, somatic	Homo sapiens	47-59
10684655-4	2000	Similar to mutations in cbb(3) and rdx, suitably constructed prrC deletion mutations lead to PS gene expression in the presence of high oxygen.	Oxygen	136-142	SCO family protein	Rhodobacter sphaeroides 2.4.1	61-65
10721144-2	2000	Conversion of As(III), which constituted over 70% of dissolved arsenic in the samples, to As(V) was fast with ozone, but sluggish with pure oxygen and air.	Oxygen	140-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
10671489-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) and the HIF-like factor (HLF) are two highly related basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) homology transcription factors that undergo dramatically increased function at low oxygen levels.	Oxygen	228-234	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
10671489-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) and the HIF-like factor (HLF) are two highly related basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) homology transcription factors that undergo dramatically increased function at low oxygen levels.	Oxygen	228-234	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
10691227-10	2000	CONCLUSIONS: A decrease in DO2 to 7.3+/-1.4 ml O2 x kg(-1) min(-1) in resting, healthy, conscious humans does not produce evidence of inadequate systemic oxygenation.	Oxygen	28-30	CD59 molecule (CD59 blood group)	Homo sapiens	59-65
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-153
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	63-69	erythropoietin	Homo sapiens	169-183
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	63-69	erythropoietin	Homo sapiens	185-188
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	99-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-153
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	99-105	erythropoietin	Homo sapiens	169-183
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Oxygen	99-105	erythropoietin	Homo sapiens	185-188
10719243-6	2000	TDO activity was appreciable at even 30 microM oxygen and rose steeply to a maximum at 40 microM.	Oxygen	47-53	tryptophan 2,3-dioxygenase	Rattus norvegicus	0-3
10656833-1	2000	Human catalase is an heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer.	Oxygen	104-110	catalase	Homo sapiens	6-14
10691227-0	2000	Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1).	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	79-85
10679488-2	2000	Although seemingly unrelated, these may all alter cellular redox state, suggesting that reactive oxygen intermediates might modulate eNOS expression.	Oxygen	97-103	nitric oxide synthase 3	Bos taurus	133-137
10719243-0	2000	Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway.	Oxygen	23-29	tryptophan 2,3-dioxygenase	Rattus norvegicus	65-91
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	Oxygen	18-24	tryptophan 2,3-dioxygenase	Rattus norvegicus	151-154
10688048-3	2000	The data presented suggest that long-term of hypoxia (10.8% O2) significantly suppresses body growth of rats and inhibits GH release and/or biosynthesis, which may in part correlate with decreased body weight gain; high circulating PRL concentration may be of significance in physiological adaptation to chronic hypoxia.	Oxygen	60-62	prolactin	Rattus norvegicus	232-235
10701033-1	2000	The in vivo P50 (P50iv) provides a useful index of haemoglobin-oxygen affinity and is calculated according to software algorithms incorporated into commercial blood gas analysers.	Oxygen	63-69	nuclear factor kappa B subunit 1	Homo sapiens	12-15
10701033-1	2000	The in vivo P50 (P50iv) provides a useful index of haemoglobin-oxygen affinity and is calculated according to software algorithms incorporated into commercial blood gas analysers.	Oxygen	63-69	nuclear factor kappa B subunit 1	Homo sapiens	17-22
11345346-0	2000	Vitreal macrophages express vascular endothelial growth factor in oxygen-induced retinopathy.	Oxygen	66-72	vascular endothelial growth factor A	Homo sapiens	28-62
10690527-7	2000	In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen.	Oxygen	143-149	hypoxia inducible lipid droplet associated	Homo sapiens	112-116
10682677-2	2000	Using these glioma models, we wished to test whether oxygen serves as a regulator of cellular VEGF expression in situ.	Oxygen	53-59	vascular endothelial growth factor A	Homo sapiens	94-98
10682677-5	2000	Northern blotting analyses of monolayer cells demonstrated significant up-regulation of VEGF mRNA in the M006X line at oxygen concentrations of 6% and below.	Oxygen	119-125	vascular endothelial growth factor A	Homo sapiens	88-92
10766028-1	2000	Proinsulin C-peptide ameliorates renal and autonomic nerve function and increases skeletal muscle blood flow, oxygen uptake and glucose transport in patients with insulin-dependent diabetes mellitus.	Oxygen	110-116	insulin	Homo sapiens	0-10
10766028-1	2000	Proinsulin C-peptide ameliorates renal and autonomic nerve function and increases skeletal muscle blood flow, oxygen uptake and glucose transport in patients with insulin-dependent diabetes mellitus.	Oxygen	110-116	insulin	Homo sapiens	11-20
11345346-12	2000	In addition, vitreal macrophages were also found to transcribe and express VEGF in the oxygen-treated animals during the vasoproliferative phase.	Oxygen	87-93	vascular endothelial growth factor A	Homo sapiens	75-79
10727072-1	2000	Maximal oxygen uptake (VO2max) in females, expressed as ml x kg(-1) x min(-1), declines steadily during the first three decades of life.	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	70-76
10670493-7	2000	In mice with oxygen-induced ischemic retinopathy there was a striking decrease in BMP-4 mRNA in the retina within 6 hours of the onset of hypoxia that was maintained for at least 5 days.	Oxygen	13-19	bone morphogenetic protein 4	Mus musculus	82-87
10646512-1	2000	Nitric oxide, which is generated in high quantities following induction of iNOS, combines with other oxygen radicals to form highly reactive, death-inducing compounds.	Oxygen	101-107	nitric oxide synthase 2	Rattus norvegicus	75-79
10766441-10	2000	Co(II) and Cd(II) complexes of non-native F1-CS peptides are more sensitive to oxidation by O2, relative to F1-SC, suggestive of a higher lability in the non-native chelate.	Oxygen	92-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	166-168	sucrose synthase 2	Zea mays	4-8
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 2	Zea mays	4-8
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 2	Zea mays	4-8
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 2	Zea mays	4-8
10640292-0	2000	Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.	Oxygen	16-22	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-90
12214610-4	2000	RESULT: In the air with 0.5% O2, AM"s survival rate and luminescence level were only 50% or 45% of the values before the exposure, and were reducing progressively with increasing dose of Vit.	Oxygen	29-31	vitrin	Oryctolagus cuniculus	187-190
10790762-3	2000	In this regard, NF-kappaB is also responsive to reactive oxygen intermediates and calcium.	Oxygen	57-63	nuclear factor kappa B subunit 1	Homo sapiens	16-25
10821417-1	2000	Reactive oxygen species (ROS; O2-, H2O2, and OH), normal by-products of cellular metabolic processes, are kept in control by antioxidant enzymes, such as catalase, glutathione peroxidase (GPX) and superoxide dismutases (SODs).	Oxygen	30-32	catalase	Homo sapiens	154-162
12214610-6	2000	To increase the concentration of oxygen in the air was advantageous in enhancing cell"s vitality and it can partly counteract the decrease of AM"s stimulated chemiluminescence level by adding Vit.	Oxygen	33-39	vitrin	Oryctolagus cuniculus	192-195
12214610-8	2000	CONCLUSION: Oxygen in the air is important for cultivated cell"s luminescence and survival, and it could lead to grave damage to the cultivated AMs when there is high concentration of Vit.	Oxygen	12-18	vitrin	Oryctolagus cuniculus	184-187
10636892-1	2000	Cytochrome c oxidase, the terminal enzyme in the electron transfer chain, catalyzes the reduction of oxygen to water in a multiple step process by utilizing four electrons from cytochrome c.	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	0-12
10640619-9	2000	This finding suggested that the mobilization of astroglial cells for the synthesis of SOD-1 protein is a response to the KA insult designed to decrease the neurotoxicity induced by oxygen-derived free radicals.	Oxygen	181-187	superoxide dismutase 1	Rattus norvegicus	86-91
10640619-10	2000	Therefore, these alterations might reflect the regulatory role of SOD-1 against oxygen-derived free radical-induced neuronal degeneration after systemic KA administration.	Oxygen	80-86	superoxide dismutase 1	Rattus norvegicus	66-71
10592513-8	2000	Furthermore, forced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) enhanced Epo production in all oxygen concentrations.	Oxygen	110-116	hypoxia-inducible factor 1-alpha	Cricetulus griseus	34-65
10592513-8	2000	Furthermore, forced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) enhanced Epo production in all oxygen concentrations.	Oxygen	110-116	hypoxia-inducible factor 1-alpha	Cricetulus griseus	67-77
10636892-1	2000	Cytochrome c oxidase, the terminal enzyme in the electron transfer chain, catalyzes the reduction of oxygen to water in a multiple step process by utilizing four electrons from cytochrome c.	Oxygen	101-107	cytochrome c, somatic	Homo sapiens	177-189
10863532-1	2000	It is an honor, and indeed fitting, to have a chapter on pulmonary oxygen toxicity included in a Festschrift for Dan Gilbert, whose contributions to the free radical theory of oxygen toxicity have been a catalyst to the last half-century of investigation in this field.	Oxygen	67-73	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
11424817-10	2000	The subsequent significant increased 2.3 DPG/Hb, ratio related to increased p50 values, could have a key role in a physiological mechanism aimed to ensure adequate oxygen delivery to the tissues and to counteract the higher oxygen affinity of fetal hemoglobin.	Oxygen	164-170	nuclear factor kappa B subunit 1	Homo sapiens	76-79
11424817-10	2000	The subsequent significant increased 2.3 DPG/Hb, ratio related to increased p50 values, could have a key role in a physiological mechanism aimed to ensure adequate oxygen delivery to the tissues and to counteract the higher oxygen affinity of fetal hemoglobin.	Oxygen	224-230	nuclear factor kappa B subunit 1	Homo sapiens	76-79
11996093-3	2000	47, 201-207) we have shown that catalase T holoenzyme is synthesized in the absence of oxygen after treatment of anaerobic yeast cultures with 0.3 M. NaCl, or during heat shock.	Oxygen	87-93	catalase T	Saccharomyces cerevisiae S288C	32-42
10615066-0	2000	Effects of reactive oxygen and nitrogen metabolites on eotaxin-induced eosinophil chemotactic activity in vitro.	Oxygen	20-26	C-C motif chemokine ligand 11	Homo sapiens	55-62
10955370-6	2000	Insulin also increased myocardial uptake of glucose (from 6+/-1 to 17+/-6 mmol/min) and lactate (from 8+/-2 to 12+/-5 mmol/min), resulting in approximately 30% increase in total oxidative substrate uptake, but without increasing myocardial oxygen consumption (7.0+/-0.7 vs. 7.1+/-0.8 ml/min).	Oxygen	240-246	insulin	Homo sapiens	0-7
10849651-2	2000	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10849651-2	2000	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10863532-1	2000	It is an honor, and indeed fitting, to have a chapter on pulmonary oxygen toxicity included in a Festschrift for Dan Gilbert, whose contributions to the free radical theory of oxygen toxicity have been a catalyst to the last half-century of investigation in this field.	Oxygen	176-182	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
10821478-2	2000	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to reduced O2 availability, including angiogenesis and glycolysis.	Oxygen	105-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10605934-3	2000	The expression and activity of the HIF-1alpha subunit are tightly regulated by cellular O2 concentration.	Oxygen	88-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
10605934-4	2000	Under hypoxic conditions, HIF-1 activates the transcription of genes encoding erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase O2 delivery or facilitate metabolic adaptation to hypoxia.	Oxygen	220-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-31
10605934-4	2000	Under hypoxic conditions, HIF-1 activates the transcription of genes encoding erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase O2 delivery or facilitate metabolic adaptation to hypoxia.	Oxygen	220-222	vascular endothelial growth factor A	Homo sapiens	136-170
10611060-0	2000	Oxygen stress increases prolyl cis/trans isomerase activity and expression of cyclophilin 18 in rabbit blastocysts.	Oxygen	0-6	peptidyl-prolyl cis-trans isomerase A	Oryctolagus cuniculus	78-92
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Oxygen	45-51	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Oxygen	45-51	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Oxygen	45-51	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
11227721-5	2000	After the individualized training programme, peak oxygen consumption on exercise (1679 +/- 100 vs 1487 +/- 89 ml.min-1, p = 0.0001) and at ventilatory threshold increased (1365 +/- 85 vs 1133 +/- 65 ml.min-1, p = 0.0001), the ventilatory threshold/peak exercise ratio increased (81.2 +/- 1.3 vs 76.7 +/- 1.4%, p = 0.0008), and there was a decrease in heart and ventilatory rates at submaximal metabolic levels (p = 0.0001).	Oxygen	50-56	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
10658829-8	2000	The O2 and O2+NO groups did not differ in CD18 expression or in intracellular oxidant production, but had significant increase in lung myeloperoxidase compared to the RA group.	Oxygen	4-6	myeloperoxidase	Homo sapiens	135-150
10658829-10	2000	The O2 group showed significantly increased lung SOD and catalase activity compared to the RA group, whereas the RA+NO and O2+NO groups did not.	Oxygen	4-6	superoxide dismutase 1	Homo sapiens	49-52
10971000-5	2000	Logistic regression analysis revealed AVP levels on day 3 were significantly correlated with the duration of oxygen dependency independent of other factors.	Oxygen	109-115	arginine vasopressin	Homo sapiens	38-41
10817351-11	2000	Lower CAT activity in our study may be the effect of higher production of ROMs, particularly O2*- and *OH.	Oxygen	93-95	catalase	Homo sapiens	6-9
12042052-0	2000	Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2.	Oxygen	4-10	interleukin 2	Homo sapiens	104-108
10821478-2	2000	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to reduced O2 availability, including angiogenesis and glycolysis.	Oxygen	105-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10601872-1	2000	An oxygen-induced iron superoxide dismutase was found in the culture fluid of the thermoacidophilic crenarchaeon Sulfolobus solfataricus during growth on glucose-rich media.	Oxygen	3-9	shikimate dehydrogenase	Saccharolobus solfataricus	23-43
11045901-2	2000	Two groups of compounds with different lengths of alkyl chains connecting the amine nitrogen and the central oxygen showed a one order difference in their 5-HT2 receptor binding affinity.	Oxygen	109-115	5-hydroxytryptamine receptor 2A	Homo sapiens	155-169
10662897-11	2000	Thus, restriction of nutrient and oxygen supply throughout fetal life was associated with suppression of renal renin and renal angiotensinogen gene expression, with no effect on hepatic angiotensinogen mRNA levels.	Oxygen	34-40	renin	Ovis aries	111-116
10662901-5	2000	At 120 rev min-1 there was also a pronounced upward shift of the O2-power output (O2-P) relationship.	Oxygen	65-67	CD59 molecule (CD59 blood group)	Homo sapiens	11-16
10662901-5	2000	At 120 rev min-1 there was also a pronounced upward shift of the O2-power output (O2-P) relationship.	Oxygen	82-84	CD59 molecule (CD59 blood group)	Homo sapiens	11-16
10662901-6	2000	At 50 W O2 between 80 and 100 rev min-1 amounted to +0.43 l min-1 but to +0.87 l min-1 between 100 and 120 rev min-1.	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
10997307-1	2000	It has been determined that serum albumin is more active in transport of lipids and POL products, the changes in erythrocyte"s metabolism and in affinity of haemoglobin to oxygen take place in organism of sportsmen-volleyball with high and low qualification under train loading.	Oxygen	172-178	albumin	Homo sapiens	28-41
10662901-6	2000	At 50 W O2 between 80 and 100 rev min-1 amounted to +0.43 l min-1 but to +0.87 l min-1 between 100 and 120 rev min-1.	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
10640274-3	2000	We find that p53 promotes Mdm2-mediated ubiquitination and proteasomal degradation of the HIF-1alpha subunit of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that regulates cellular energy metabolism and angiogenesis in response to oxygen deprivation.	Oxygen	259-265	tumor protein p53	Homo sapiens	13-16
10662901-6	2000	At 50 W O2 between 80 and 100 rev min-1 amounted to +0.43 l min-1 but to +0.87 l min-1 between 100 and 120 rev min-1.	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
10640274-3	2000	We find that p53 promotes Mdm2-mediated ubiquitination and proteasomal degradation of the HIF-1alpha subunit of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that regulates cellular energy metabolism and angiogenesis in response to oxygen deprivation.	Oxygen	259-265	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
10640274-3	2000	We find that p53 promotes Mdm2-mediated ubiquitination and proteasomal degradation of the HIF-1alpha subunit of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that regulates cellular energy metabolism and angiogenesis in response to oxygen deprivation.	Oxygen	259-265	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-95
10662901-11	2000	However, beyond 100 rev min-1 there is a decrease in external power that can be delivered for an given O2 with an associated earlier onset of metabolic acidosis and clearly this will be disadvantageous for sustained high intensity exercise.	Oxygen	103-105	CD59 molecule (CD59 blood group)	Homo sapiens	24-29
10567925-7	2000	Atmospheric O(2) inhibited the synthesis of a major basement membrane protein (Type IV collagen), a major surface protein (PECAM-1), and increased the synthesis of von Willebrand factor (vWf).	Oxygen	12-16	von Willebrand factor	Homo sapiens	164-185
10567925-7	2000	Atmospheric O(2) inhibited the synthesis of a major basement membrane protein (Type IV collagen), a major surface protein (PECAM-1), and increased the synthesis of von Willebrand factor (vWf).	Oxygen	12-16	von Willebrand factor	Homo sapiens	187-190
10807526-7	2000	Our data suggest that tachyarrhythmia-induced mechanical overload can increase the serum VEGF level, which can be a useful clinical marker for relative myocardial oxygen shortage in such patients.	Oxygen	163-169	vascular endothelial growth factor A	Homo sapiens	89-93
10847561-2	2000	It also discusses the significance of amyloid beta in initiating the generation of partially reduced oxygen species and points out their role in damaging essential macromolecules in the CNS which leads to neuronal dysfunction and loss.	Oxygen	101-107	amyloid beta precursor protein	Homo sapiens	38-50
10594042-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) functions as a transcription factor that is activated by decreased cellular oxygen concentrations to induce expression of a network of genes involved in angiogenesis, erythropoiesis, and glucose homeostasis.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
10594042-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) functions as a transcription factor that is activated by decreased cellular oxygen concentrations to induce expression of a network of genes involved in angiogenesis, erythropoiesis, and glucose homeostasis.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
10575000-8	1999	In this study, we examined the expression of the recently isolated VEGF gene family members (placenta growth factor (PlGF), VEGF-B, and VEGF-C) in human dermal microvascular endothelial cells and bovine retinal pericytes cultured under various oxygen tensions.	Oxygen	244-250	vascular endothelial growth factor A	Homo sapiens	67-71
10603309-4	1999	HIF-1 is a heterodimeric transcription factor tightly regulated by oxygen concentration.	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
10716201-3	1999	In normoxia (20% O2), 2-day exposure to ET-1 (10-1000 nM) caused a dose-dependent increase in BrdU uptake which peaked (approximately 55% of TH+ cells) at around 500 nM ET-1.	Oxygen	17-19	endothelin 1	Rattus norvegicus	40-44
10994872-7	2000	We could monitor formation of ferrous myeloperoxidase as well as its direct transition to compound II by addition of molecular oxygen.	Oxygen	127-133	myeloperoxidase	Homo sapiens	38-53
11712437-3	2000	The regression analysis of HOA, LPO and AD parameters in investigated material indicated the close positive correlations of oxygen pressure for hemoglobin half-saturation (p50) with CD, TBARS, and SB, and negative correlation of p50 with alpha-T and CAT.	Oxygen	124-130	catalase	Rattus norvegicus	250-253
10594078-1	1999	Cu/Zn superoxide dismutase (SOD-1) is a key enzyme in oxygen metabolism in the brain.	Oxygen	54-60	superoxide dismutase 1, soluble	Mus musculus	28-33
10641731-6	1999	The formation of these catecholestrogen-induced DNA strand breaks was associated with the utilization of oxygen and the generation of H2O2, because catalase inhibited the DNA cleaving activity of 4-OHE2.	Oxygen	105-111	catalase	Homo sapiens	148-156
10622706-1	1999	The O2*- -generating step of plant peroxidases during their catalytic cycle is represented by the decay of compound III (CoIII) into ferriperoxidase, which most likely involves the dissociation of a ferric-O2*- complex to yield the ferric form of the enzyme and O2*-.	Oxygen	4-6	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	107-119
10622706-1	1999	The O2*- -generating step of plant peroxidases during their catalytic cycle is represented by the decay of compound III (CoIII) into ferriperoxidase, which most likely involves the dissociation of a ferric-O2*- complex to yield the ferric form of the enzyme and O2*-.	Oxygen	206-208	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	107-119
10620398-5	1999	Northern analysis demonstrated that LDH-B mRNA is developmentally regulated in the chick retina according to a time course that correlates with oxygen availability.	Oxygen	144-150	lactate dehydrogenase B	Gallus gallus	36-41
10620398-8	1999	LDH-B mRNA increased to control levels in retinal cells exposed to hypoxia then reperfused with oxygen, while the opposite was true for LDH-A, an hypoxia inducible gene.	Oxygen	96-102	lactate dehydrogenase B	Gallus gallus	0-5
10620398-9	1999	These data demonstrate that LDH-B gene repression after hypoxia and reactivation after oxygen reperfusion occurs in both vascular and avascular retinal cells.	Oxygen	87-93	lactate dehydrogenase B	Gallus gallus	28-33
10620398-10	1999	Oxygen regulated expression of LDH-B is opposite and complementary to that of LDH-A and provides a system to elucidate the mechanisms underlying hypoxic gene repression and reactivation after reperfusion.	Oxygen	0-6	lactate dehydrogenase B	Gallus gallus	31-36
10643566-2	1999	The expression of insulin-like growth factor (IGF)-I, -II, and -IIR mRNAs and proteins was studied in FB and HTBE cells cultured separately in 95% oxygen and 5% CO2 for 48 hours.	Oxygen	147-153	insulin like growth factor 1	Homo sapiens	18-67
10594930-1	1999	Superoxide dismutase (SOD) converts superoxide radical to H(2)O(2), which is in turn broken down to water and oxygen by catalase.	Oxygen	110-116	catalase	Homo sapiens	120-128
10660846-10	1999	Exposure of healthy volunteers to less severe but more prolonged hypoxia did not induce APP, although a time dependent increase of serum erythropoietin (EPO) was measurable under these conditions, indicating the activation of oxygen dependent gene expression.	Oxygen	226-232	erythropoietin	Homo sapiens	137-151
10660846-10	1999	Exposure of healthy volunteers to less severe but more prolonged hypoxia did not induce APP, although a time dependent increase of serum erythropoietin (EPO) was measurable under these conditions, indicating the activation of oxygen dependent gene expression.	Oxygen	226-232	erythropoietin	Homo sapiens	153-156
10660846-12	1999	(ii) Despite in vitro evidence for similarities in the oxygen dependent regulation of APP and EPO production, the oxygen sensitivity of these proteins in vivo is different.	Oxygen	55-61	erythropoietin	Homo sapiens	94-97
10604577-3	1999	METHODS: Reactive oxygen scavenging activity of SOD conjugates was tested in livers of bile duct ligated rats.	Oxygen	18-24	superoxide dismutase 1	Homo sapiens	48-51
10616207-10	1999	Thus our data indicate that the coexpression of VEGF and VEGFR-1 in tumor cells could have an inhibitory effect on tumor cell proliferation and migration, a mechanism possibly induced as a response to a deficiency in nutrient and oxygen supply.	Oxygen	230-236	vascular endothelial growth factor A	Homo sapiens	48-52
10616207-10	1999	Thus our data indicate that the coexpression of VEGF and VEGFR-1 in tumor cells could have an inhibitory effect on tumor cell proliferation and migration, a mechanism possibly induced as a response to a deficiency in nutrient and oxygen supply.	Oxygen	230-236	fms related receptor tyrosine kinase 1	Homo sapiens	57-64
10594118-6	1999	By preventing severe respiratory restriction, AOX acts to prevent both redirections in C metabolism and the excessive generation of harmful active oxygen species in the mitochondrion.	Oxygen	147-153	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	46-49
10570058-6	1999	Both L-arginine (10 mM) and NOC-18 (0.3 mM) counteracted the stimulatory effect on hERG1 outward currents induced by the radical oxygen species-generating system FeSO(4) (25 microM)/ascorbic acid (50 microM; Fe/Asc).	Oxygen	129-135	PYD and CARD domain containing	Homo sapiens	211-214
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	113-119	superoxide dismutase 1	Homo sapiens	4-31
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	113-119	superoxide dismutase 1	Homo sapiens	33-36
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	113-119	catalase	Homo sapiens	207-215
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	170-176	superoxide dismutase 1	Homo sapiens	4-31
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	170-176	superoxide dismutase 1	Homo sapiens	33-36
10705716-5	1999	The superoxide dismutase enzyme (SOD) catalyzes dismutation of the superoxide radical into hydrogen peroxide and oxygen hydrogen peroxide is in turn reduced to water and oxygen by peroxidase glutathione and catalase enzymes.	Oxygen	170-176	catalase	Homo sapiens	207-215
10551817-1	1999	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor and erythropoietin in low oxygen conditions.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10647213-2	1999	Antioxidants are especially critical in root nodules because leghemoglobin, which is present at high concentrations in nodules, is prone to autoxidation and production of activated oxygen species such as O2.- and H2O2.	Oxygen	181-187	leghemoglobin A	Glycine max	61-74
10647213-2	1999	Antioxidants are especially critical in root nodules because leghemoglobin, which is present at high concentrations in nodules, is prone to autoxidation and production of activated oxygen species such as O2.- and H2O2.	Oxygen	204-206	leghemoglobin A	Glycine max	61-74
10563795-1	1999	Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed.	Oxygen	58-64	cytochrome c, somatic	Homo sapiens	0-12
10563795-1	1999	Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed.	Oxygen	144-150	cytochrome c, somatic	Homo sapiens	0-12
10563795-5	1999	It is more likely that only three protons are pumped during the second half of the catalytic cycle of cytochrome c oxidase after the reaction with oxygen.	Oxygen	147-153	cytochrome c, somatic	Homo sapiens	102-114
10563817-4	1999	It is proposed that this pi orbital interaction with the reduced biopterins and alpha-MSH could provide the basis for the observed stability of these pterins to oxidation by either molecular oxygen or photooxidation by UVB (290-320 nm) light.	Oxygen	191-197	proopiomelanocortin	Homo sapiens	80-89
10576684-1	1999	By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.	Oxygen	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
10551817-1	1999	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor and erythropoietin in low oxygen conditions.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10551817-1	1999	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor and erythropoietin in low oxygen conditions.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	88-122
10551817-1	1999	Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor and erythropoietin in low oxygen conditions.	Oxygen	149-155	erythropoietin	Homo sapiens	127-141
10516398-5	1999	Hypoxia (1% oxygen) and hypoxia-conditioned media increased PASMC numbers, and this mitogenic effect was abolished by anti-bFGF, but not by anti-PDGF or anti-VEGF.	Oxygen	12-18	fibroblast growth factor 2	Homo sapiens	123-127
10564216-6	1999	Furthermore, ICV infusion of the Y5 selective agonist D-[Trp(32)]-NPY significantly reduced oxygen consumption and energy expenditure of rats as measured by indirect calorimetry.	Oxygen	92-98	neuropeptide Y	Rattus norvegicus	66-69
10586561-11	1999	Anesthesia was induced with midazolam 3 mg, sevoflurane 5%, nitrous oxide 8 l.min-1 in oxygen 4 l.min-1.	Oxygen	87-93	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
10548590-4	1999	Administration of a combined dose of superoxide dismutase and catalase minimized the action of Hb and iron-EDTA, suggesting that both O(2)(.-) and H(2)O(2) are involved in the toxic action of Hb in this rat model.	Oxygen	134-138	catalase	Rattus norvegicus	62-70
10542067-6	1999	26, 37-43] have suggested that cytochrome oxidase is sensitive to oxygen concentrations below about 40 microM, but proposed that this sensitivity is obscured in intact cells because an increase in reduction state of cytochrome c acts to maintain oxygen consumption.	Oxygen	66-72	cytochrome c, somatic	Homo sapiens	216-228
10542067-6	1999	26, 37-43] have suggested that cytochrome oxidase is sensitive to oxygen concentrations below about 40 microM, but proposed that this sensitivity is obscured in intact cells because an increase in reduction state of cytochrome c acts to maintain oxygen consumption.	Oxygen	246-252	cytochrome c, somatic	Homo sapiens	216-228
10552089-9	1999	Oxygen delivery and consumption were 151+/-13 and 88+/-15 microl O(2) min(-1) g(-1) at rest and increased to 291+/-31 and 216+/-31 microl O(2) min(-1) g(-1), respectively, during pharmacological stress (P&lt;0.001).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	70-76
10552089-9	1999	Oxygen delivery and consumption were 151+/-13 and 88+/-15 microl O(2) min(-1) g(-1) at rest and increased to 291+/-31 and 216+/-31 microl O(2) min(-1) g(-1), respectively, during pharmacological stress (P&lt;0.001).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	143-149
10582858-10	1999	Partial pressures of oxygen required for various degrees of hemoglobin saturation were higher in meconium-exposed samples; P50 (30.1+/-0.6 vs. 27.8+/-0.4 mmHg, P &lt; 0.01); P75 (46.9+/-0.6 vs. 43.1+/-0.5 mmHg, P &lt; .001); P90 (69.2+/-1 vs. 63.3+/-1 mmHg, P &lt; 0.01).	Oxygen	21-27	nuclear factor kappa B subunit 1	Homo sapiens	123-126
10589791-5	1999	Immunohistochemical analysis of tumor lesions indicated that IL-8 overexpression was predominant in the regions surrounding necrotic areas, where cells were exposed to low oxygen tension (hypoxia) and acidic pH.	Oxygen	172-178	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10586561-11	1999	Anesthesia was induced with midazolam 3 mg, sevoflurane 5%, nitrous oxide 8 l.min-1 in oxygen 4 l.min-1.	Oxygen	87-93	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
10545952-1	1999	Mammalian cytochrome c oxidase (COX) catalyses the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.	Oxygen	115-121	cytochrome c, somatic	Homo sapiens	10-22
10531389-0	1999	Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin.	Oxygen	23-29	mitogen-activated protein kinase 8	Homo sapiens	62-85
10545952-1	1999	Mammalian cytochrome c oxidase (COX) catalyses the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.	Oxygen	115-121	cytochrome c, somatic	Homo sapiens	89-101
10876842-2	1999	Both SEA and LPS, when injected to animals, produced stimulating influence on the oxygen metabolism of phagocytizing cells.	Oxygen	82-88	toll-like receptor 4	Mus musculus	13-16
10876842-4	1999	Under the conditions of the development of lethal toxic shock, i.e. after the combined injection of SEA and LPS, the synergic activation of oxygen metabolism was observed, which was also manifested by the pronounced production of TNF alpha and the increased synthesis of gamma-interferon.	Oxygen	140-146	toll-like receptor 4	Mus musculus	108-111
10876842-4	1999	Under the conditions of the development of lethal toxic shock, i.e. after the combined injection of SEA and LPS, the synergic activation of oxygen metabolism was observed, which was also manifested by the pronounced production of TNF alpha and the increased synthesis of gamma-interferon.	Oxygen	140-146	tumor necrosis factor	Mus musculus	230-239
10876842-4	1999	Under the conditions of the development of lethal toxic shock, i.e. after the combined injection of SEA and LPS, the synergic activation of oxygen metabolism was observed, which was also manifested by the pronounced production of TNF alpha and the increased synthesis of gamma-interferon.	Oxygen	140-146	interferon gamma	Mus musculus	271-287
10521242-4	1999	With increasing oxygen concentrations above 6%, cardiac myocytes produce increasing amounts of angiotensin I, which is converted to angiotensin II by the blood vessel.	Oxygen	16-22	angiotensinogen	Homo sapiens	95-108
10542317-0	1999	Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene.	Oxygen	21-27	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	63-103
10540427-2	1999	This process is the first structural evidence for an effective method for the activation of molecular oxygen as postulated for the cytochrome P-450 system.	Oxygen	102-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	131-147
10521242-4	1999	With increasing oxygen concentrations above 6%, cardiac myocytes produce increasing amounts of angiotensin I, which is converted to angiotensin II by the blood vessel.	Oxygen	16-22	angiotensinogen	Homo sapiens	132-146
10469539-4	1999	Based on EXAFS results and bond valence analysis, plausible surface complexation reactions for Co(II) sorption on these two surfaces can be written as represent surface water molecules, hydroxyl groups, and oxygens bonded to one, two, and three Al cations, respectively.	Oxygen	207-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10516167-4	1999	Levels of IL-1alpha and IL-1beta mRNA increased in human VSMC after 24-48 h of incubation in low O(2) compared with levels in normoxic cells and then decreased upon subsequent reoxygenation.	Oxygen	97-101	interleukin 1 beta	Homo sapiens	24-32
10519507-6	1999	Cultures of astrocytes overexpressing bcl-xL or a control gene were injured by hydrogen peroxide, glucose deprivation, or combined oxygen and glucose deprivation.	Oxygen	131-137	BCL2 like 1	Homo sapiens	38-44
10673885-8	1999	Apnoea occurred in five of 15 patients who did not receive oxygen before sevoflurane and in four of 13 who received oxygen 6 litre min-1 (P &lt; 0.05).	Oxygen	116-122	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
10506576-3	1999	Transgenic animals stably overexpressed glutathione reductase by up to 100% throughout adult life and under continuous exposure to 100% oxygen or air.	Oxygen	136-142	Thioredoxin reductase-1	Drosophila melanogaster	40-61
10547153-2	1999	We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and natural killer (NK) cells, became anergic to the T cell and NK cell activator interleukin-2 (IL-2) after exposure to MO-derived reactive oxygen metabolites and subsequently acquired features characteristic of apoptosis.	Oxygen	242-248	interleukin 2	Homo sapiens	183-196
10547153-2	1999	We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and natural killer (NK) cells, became anergic to the T cell and NK cell activator interleukin-2 (IL-2) after exposure to MO-derived reactive oxygen metabolites and subsequently acquired features characteristic of apoptosis.	Oxygen	242-248	interleukin 2	Homo sapiens	198-202
10589830-3	1999	To identify genes which are involved in the oxygen-dependent activation of the Gal4-Pos9 hybrid protein we screened for mutants that failed to induce the heterologous test system upon oxidative stress (fap mutants for factors activating Pos9).	Oxygen	44-50	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	84-88
10589830-3	1999	To identify genes which are involved in the oxygen-dependent activation of the Gal4-Pos9 hybrid protein we screened for mutants that failed to induce the heterologous test system upon oxidative stress (fap mutants for factors activating Pos9).	Oxygen	44-50	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	237-241
10535739-0	1999	Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF.	Oxygen	0-6	branchless	Drosophila melanogaster	78-81
10535739-5	1999	During larval life, oxygen deprivation stimulates expression of Bnl, and the secreted growth factor functions as a chemoattractant that guides new terminal branches to the expressing cells.	Oxygen	20-26	branchless	Drosophila melanogaster	64-67
10529480-8	1999	Attenuation of bcl-2 expression by antisense oligonucleotides decreased the proportion of surviving neurons by approximately 50% after 48 h of exposure to 0.1% oxygen.	Oxygen	160-166	BCL2, apoptosis regulator	Rattus norvegicus	15-20
10598322-1	1999	This study tested whether a strain of heterozygous Mn superoxide dismutase (SOD) knockout mice differed from wild types in response to lethal (100 or 85%) or sublethal (50 or 75%) oxygen exposures.	Oxygen	180-186	superoxide dismutase 2, mitochondrial	Mus musculus	76-79
10618906-8	1999	CONCLUSIONS: The use of new oxygen permeable polyolefin containers and additive solutions, PAS-2, allows us to obtain pools of PC with suitable metabolic parameters during storage.	Oxygen	28-34	glycophorin A (MNS blood group)	Homo sapiens	91-96
10500158-2	1999	Here, we show that the glbN gene encodes a dimeric hemoglobin (HbN) that binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees C) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate.	Oxygen	79-85	hemoglobin GlbN	Mycobacterium tuberculosis H37Rv	23-27
10487921-9	1999	In vitro binding studies showed that Rox1p binds to the region responsible for oxygen regulation.	Oxygen	79-85	Rox1p	Saccharomyces cerevisiae S288C	37-42
10487921-12	1999	Thus, the activation of ATF1 transcription is dependent on Rap1p, and the Rox1p-Tup1p-Ssn6p hypoxic repressor complex is responsible for repression by oxygen.	Oxygen	151-157	Rox1p	Saccharomyces cerevisiae S288C	74-79
10460757-0	1999	Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.	Oxygen	0-6	tumor protein p53	Homo sapiens	51-54
10513558-11	1999	Based on these findings, we concluded that e-NOS exists in mitochondria and that NO* may play an important protective role in reperfusion cardiac injury after ischemia, by inhibiting the Ca2+ influx into mitochondria which are otherwise damaged by *O2-.	Oxygen	249-251	nitric oxide synthase, endothelial	Cavia porcellus	43-48
16118870-0	1999	Oxidative cleavage of vic-diols to aldehydes with dioxygen catalyzed by Ru(PPh3)3Cl2 on active carbon.	Oxygen	50-58	caveolin 1	Homo sapiens	75-79
16118870-1	1999	[reaction: see text] A variety of vic-diols were first successfully cleaved to the corresponding aldehydes with dioxygen catalyzed by Ru(PPh3)3Cl2 on active carbon in fair to good yields.	Oxygen	112-120	caveolin 1	Homo sapiens	137-141
10460757-0	1999	Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.	Oxygen	0-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
10460757-0	1999	Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.	Oxygen	0-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	63-67
10460757-0	1999	Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.	Oxygen	0-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-72
10460757-2	1999	Recent studies indicate that oxygen augments the expression of p53 and p21(WAF1/CIP1), and increases apoptotic labeling of airway epithelial cells.	Oxygen	29-35	tumor protein p53	Homo sapiens	63-66
10460757-2	1999	Recent studies indicate that oxygen augments the expression of p53 and p21(WAF1/CIP1), and increases apoptotic labeling of airway epithelial cells.	Oxygen	29-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	71-74
10460757-2	1999	Recent studies indicate that oxygen augments the expression of p53 and p21(WAF1/CIP1), and increases apoptotic labeling of airway epithelial cells.	Oxygen	29-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-79
10460757-2	1999	Recent studies indicate that oxygen augments the expression of p53 and p21(WAF1/CIP1), and increases apoptotic labeling of airway epithelial cells.	Oxygen	29-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-84
10484472-2	1999	We described the effects of hyperoxia on inducible nitric oxide synthase (iNOS) expression and NO production in the lungs of rats exposed to high concentrations of oxygen.	Oxygen	164-170	nitric oxide synthase 2	Rattus norvegicus	41-72
10460757-4	1999	The present study was conducted to determine whether oxygen alters the expression of p53 and p21(WAF1/CIP1) in human bronchial smooth-muscle cells (BSMC).	Oxygen	53-59	tumor protein p53	Homo sapiens	85-88
10484472-2	1999	We described the effects of hyperoxia on inducible nitric oxide synthase (iNOS) expression and NO production in the lungs of rats exposed to high concentrations of oxygen.	Oxygen	164-170	nitric oxide synthase 2	Rattus norvegicus	74-78
10460757-4	1999	The present study was conducted to determine whether oxygen alters the expression of p53 and p21(WAF1/CIP1) in human bronchial smooth-muscle cells (BSMC).	Oxygen	53-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	93-96
10460757-4	1999	The present study was conducted to determine whether oxygen alters the expression of p53 and p21(WAF1/CIP1) in human bronchial smooth-muscle cells (BSMC).	Oxygen	53-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-106
10460757-12	1999	Furthermore, high oxygen levels induce S-phase arrest and increased expression of p53 and p21(WAF1/CIP1).	Oxygen	18-24	tumor protein p53	Homo sapiens	82-85
10460757-12	1999	Furthermore, high oxygen levels induce S-phase arrest and increased expression of p53 and p21(WAF1/CIP1).	Oxygen	18-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-93
10460757-12	1999	Furthermore, high oxygen levels induce S-phase arrest and increased expression of p53 and p21(WAF1/CIP1).	Oxygen	18-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-103
10517163-9	1999	The crystal structure is stabilized by intermolecular hydrogen bonds involving NH of Val1 and carbonyl oxygen of a symmetry related (-x, y - 1/2, 1/2 + z) deltaPhe2 and NH of deltaPhe2 with carbonyl oxygen of a symmetry related (x, y1/2, 1/2 + z) Ile4.	Oxygen	103-109	RNA, Ro60-associated Y1	Homo sapiens	232-245
10482305-1	1999	The optimal level of oxygen-dependent microbicidal activity in human neutrophils depends on the generation of highly toxic products, including hypochlorous acid, by hydrogen peroxide in the presence of chloride anion and the neutrophil granule protein myeloperoxidase (MPO).	Oxygen	21-27	myeloperoxidase	Homo sapiens	252-267
10482305-1	1999	The optimal level of oxygen-dependent microbicidal activity in human neutrophils depends on the generation of highly toxic products, including hypochlorous acid, by hydrogen peroxide in the presence of chloride anion and the neutrophil granule protein myeloperoxidase (MPO).	Oxygen	21-27	myeloperoxidase	Homo sapiens	269-272
10474795-8	1999	Furthermore, transient transfection studies using the VEGF promoter containing an oxygen-responsive enhancer element failed to show induction in cells pretreated by subjection to chronic hypoxia.	Oxygen	82-88	vascular endothelial growth factor A	Homo sapiens	54-58
10517163-9	1999	The crystal structure is stabilized by intermolecular hydrogen bonds involving NH of Val1 and carbonyl oxygen of a symmetry related (-x, y - 1/2, 1/2 + z) deltaPhe2 and NH of deltaPhe2 with carbonyl oxygen of a symmetry related (x, y1/2, 1/2 + z) Ile4.	Oxygen	199-205	RNA, Ro60-associated Y1	Homo sapiens	232-245
10438466-1	1999	An activation domain in p67(phox) (residues within 199-210) is essential for cytochrome b(558)-dependent activation of NADPH superoxide (O2(-.))	Oxygen	137-139	CD33 molecule	Homo sapiens	24-27
10852035-4	1999	The study revealed that IL1 beta and the natural complex of cytokines primed peritoneal exudate cells for the production of active forms of oxygen.	Oxygen	140-146	interleukin 1 beta	Rattus norvegicus	24-32
10471290-7	1999	This agrees with our observation, using spin traps, that mainly singlet oxygen is produced by the complex of hypericin with the molten globule of acetylcholinesterase.	Oxygen	72-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-166
10463582-1	1999	Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other proteins involved in O2 homeostasis and tumor progression.	Oxygen	186-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10463582-1	1999	Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other proteins involved in O2 homeostasis and tumor progression.	Oxygen	186-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10463582-1	1999	Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other proteins involved in O2 homeostasis and tumor progression.	Oxygen	186-188	vascular endothelial growth factor A	Homo sapiens	119-153
10463582-2	1999	The expression and transcriptional activity of the HIF-1alpha subunit is regulated by the cellular O2 concentration.	Oxygen	99-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
10455137-1	1999	The nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to L-citrulline and NO through consumption of oxygen bound to the heme.	Oxygen	116-122	nitric oxide synthase 2	Homo sapiens	4-25
10464484-3	1999	More than 100% of non-NO3- oxygen relative to NO3- oxygen can still be found in forest soil water samples after cleanup if improper cleanup strategies, e.g., adsorption onto activated carbon, are used.	Oxygen	27-33	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
10464484-3	1999	More than 100% of non-NO3- oxygen relative to NO3- oxygen can still be found in forest soil water samples after cleanup if improper cleanup strategies, e.g., adsorption onto activated carbon, are used.	Oxygen	51-57	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
10464484-4	1999	Such non-NO3- oxygen compounds will bias O-isotopic data.	Oxygen	14-20	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
10438466-1	1999	An activation domain in p67(phox) (residues within 199-210) is essential for cytochrome b(558)-dependent activation of NADPH superoxide (O2(-.))	Oxygen	137-139	CD33 molecule	Homo sapiens	28-32
10438466-8	1999	The activation domain on p67(phox) was critical for regulating flavin reduction, since mutations in this region that decreased O2(-.)	Oxygen	127-129	CD33 molecule	Homo sapiens	25-28
10438532-8	1999	We suggest that TNF-alpha-induced apoptosis involves PKC-beta and then ceramide and, in turn, caspase-1 and/or -4, whereas anti-Fas mAb-induced apoptosis utilizes reactive oxygen intermediates and, in turn, caspase-3 and/or -7.	Oxygen	172-178	tumor necrosis factor	Homo sapiens	16-25
10438466-8	1999	The activation domain on p67(phox) was critical for regulating flavin reduction, since mutations in this region that decreased O2(-.)	Oxygen	127-129	CD33 molecule	Homo sapiens	29-33
10468195-2	1999	The role of H2O2 in these rats may be studied modulating the amount or activity of catalase, which breakdowns H2O2 to water and oxygen.	Oxygen	128-134	catalase	Rattus norvegicus	83-91
10458170-7	1999	Oxygen supplementation (hyperoxia) during detachment mitigated all these changes, reducing photoreceptor death, maintaining the specialized structures of surviving photoreceptors, and stabilizing the bFGF within the retina.	Oxygen	0-6	fibroblast growth factor 2	Homo sapiens	200-204
11207750-10	1999	In addition to chlorate, strain CKB can also couple acetate oxidation to the reduction of oxygen or perchlorate.	Oxygen	90-96	creatine kinase B	Homo sapiens	32-35
11207750-14	1999	Under anaerobic conditions, strain CKB can dismutate chlorite into chloride and O2, and is only the second organism shown to be capable of this metabolism.	Oxygen	80-82	creatine kinase B	Homo sapiens	35-38
10440381-1	1999	Cell respiration in mitochondria and some bacteria is catalysed by cytochrome c oxidase, which reduces O2 to water, coupled with translocation of four protons across the mitochondrial or bacterial membrane.	Oxygen	103-105	cytochrome c, somatic	Homo sapiens	67-79
10460304-2	1999	The congenital disorder is charaterized by a lack or major reduction of catalase, an enzyme that catalyzes the decomposition of hydrogen peroxide to oxygen and water.	Oxygen	149-155	catalase	Homo sapiens	72-80
10430608-3	1999	TLR4 expression levels in cardiac myocytes and in coronary microvascular endothelial cells could be enhanced by either LPS or IL-1beta, an effect inhibited by the oxygen radical scavenger PDTC.	Oxygen	163-169	interleukin 1 beta	Homo sapiens	126-134
10546471-6	1999	In 29 patients enrolled, the mean (+/- SD) O2 flow in L.min-1 was 1.5 +/- 0.6 during sleep, 1.4 +/- 0.6 during rest and 2.3 +/- 1.1 during exercise.	Oxygen	43-45	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
10440381-2	1999	The enzyme"s catalytic cycle consists of a reductive phase, in which the oxidized enzyme receives electrons from cytochrome c, and an oxidative phase, in which the reduced enzyme is oxidized by O2.	Oxygen	194-196	cytochrome c, somatic	Homo sapiens	113-125
10440583-4	1999	Superoxide dismutase (SOD), but not catalase or sodium formate, inhibited this NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction.	Oxygen	117-119	superoxide dismutase 1	Homo sapiens	0-20
10393722-14	1999	IMPLICATIONS: 4-HPR may form the basis for a novel, p53-independent chemotherapy that operates through increased intracellular levels of ceramide and that retains cytotoxicity under reduced oxygen conditions.	Oxygen	190-196	tumor protein p53	Homo sapiens	52-55
10360831-7	1999	We demonstrated that over-expression of bcl-2 inhibited LND-induced apoptosis, while reducing 14CO2 production, oxygen uptake and ATP content, whereas aerobic lactate production was essentially unaffected.	Oxygen	112-118	BCL2 apoptosis regulator	Homo sapiens	40-45
10409243-18	1999	We speculate that after hyperoxic lung injury, signals through the basement membrane confer specific protection against oxygen-induced DNA strand breakage and apoptosis through an ERK activation-dependent pathway.	Oxygen	120-126	Eph receptor B1	Rattus norvegicus	180-183
10417465-6	1999	In all groups, oxygen was insufflated under the drapes at a constant flow of 21.min-1.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
10417465-9	1999	An oxygen supply of 21.min-1 prevented hypoxaemia but not hypercapnia.	Oxygen	3-9	CD59 molecule (CD59 blood group)	Homo sapiens	23-28
10440583-4	1999	Superoxide dismutase (SOD), but not catalase or sodium formate, inhibited this NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction.	Oxygen	117-119	superoxide dismutase 1	Homo sapiens	22-25
10440583-4	1999	Superoxide dismutase (SOD), but not catalase or sodium formate, inhibited this NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction.	Oxygen	117-119	nuclear factor kappa B subunit 1	Homo sapiens	79-88
10405206-5	1999	IgG fractions from anti-PR3-positive patients induced more oxygen radical release from tumor necrosis factor-alpha-primed neutrophils compared with IgG fractions from anti-MPO-positive patients, as assessed by ferricytochrome c reduction (P &lt; 0.05) and dihydrorhodamine 123 oxidation (P &lt; 0.01).	Oxygen	59-65	tumor necrosis factor	Homo sapiens	87-114
10408392-0	1999	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines.	Oxygen	44-50	vascular endothelial growth factor A	Homo sapiens	94-128
10408392-0	1999	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines.	Oxygen	44-50	vascular endothelial growth factor A	Homo sapiens	130-134
10408392-5	1999	Suspension cultures of three human cervical cancer cell lines, SiHa, ME-180 and HeLa, were used to investigate up-regulation of VEGF mRNA levels following exposure to precisely defined oxygen concentrations for 2 or 4 h. An oxygen sensor was used to confirm the actual levels of dissolved oxygen present.	Oxygen	185-191	vascular endothelial growth factor A	Homo sapiens	128-132
10408392-6	1999	The oxygen concentrations which caused half-maximal upregulation (the Km value) of VEGF mRNA level in the three cell lines were similar except for one instance (Km at 4 h: SiHa 27.0 +/- 5.7 microM, ME-180 16.8 +/- 3.3 microM, HeLa 13.0 +/- 1.8 microM, SiHa and HeLa P = 0.01).	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	83-87
10450791-0	1999	Effects of insulin on N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated production of reactive oxygen metabolites from normal human neutrophils.	Oxygen	111-117	insulin	Homo sapiens	11-18
17883223-4	1999	A new model incorporating cell-specific parameters is proposed here to quantify the survival advantage of mutant or null p53 cells over their wild-type counterparts at any level of oxygen deprivation.	Oxygen	181-187	tumor protein p53	Homo sapiens	121-124
10450791-1	1999	OBJECTIVE AND DESIGN: To further understand the mechanisms behind defective neutrophil function in diabetes mellitus, the ability of insulin to affect the production and metabolism of reactive oxygen metabolites in normal human neutrophils was studied.	Oxygen	193-199	insulin	Homo sapiens	133-140
10450791-6	1999	CONCLUSIONS: These results suggest that elevated levels of insulin do not affect the NADPH-oxidase activity but, together with superoxide anions, interfere with myeloperoxidase availability and a subsequent myeloperoxidase-dependent generation of reactive oxygen metabolites in fMet-Leu-Phe-stimulated normal human neutrophils.	Oxygen	256-262	insulin	Homo sapiens	59-66
10450791-6	1999	CONCLUSIONS: These results suggest that elevated levels of insulin do not affect the NADPH-oxidase activity but, together with superoxide anions, interfere with myeloperoxidase availability and a subsequent myeloperoxidase-dependent generation of reactive oxygen metabolites in fMet-Leu-Phe-stimulated normal human neutrophils.	Oxygen	256-262	myeloperoxidase	Homo sapiens	207-222
10402422-7	1999	We also found that the activities of the active oxygen scavengers superoxide dismutase and ascorbate peroxidase were enhanced significantly in pst1 plants.	Oxygen	48-54	peroxidase	Arabidopsis thaliana	101-111
10415549-10	1999	Interestingly, this oxidase is activated upon stimulation with angiotension II, suggesting that under all conditions of an activated circulating and/or local renin-angiotensin system endothelial dysfunction secondary to increased vascular O2-.	Oxygen	239-241	renin	Homo sapiens	158-163
10366759-3	1999	Previously, we reported that exposing human dermal fibroblasts to UVA in the presence of AGEs that were prepared with bovine serum albumin (BSA) decreased the cell viability due to superoxide anion radical s (.O2(-)) and hydroxyl radicals (.OH) generated by AGEs under UVA irradiation, and active oxygen species are detected with ESR spin-trapping.	Oxygen	210-212	albumin	Homo sapiens	125-138
10366759-3	1999	Previously, we reported that exposing human dermal fibroblasts to UVA in the presence of AGEs that were prepared with bovine serum albumin (BSA) decreased the cell viability due to superoxide anion radical s (.O2(-)) and hydroxyl radicals (.OH) generated by AGEs under UVA irradiation, and active oxygen species are detected with ESR spin-trapping.	Oxygen	297-303	albumin	Homo sapiens	125-138
10750596-8	1999	Bradykinin and SNAP caused dose-dependent reductions in myocardial oxygen consumption (p &lt;0.05).	Oxygen	67-73	kininogen 1	Homo sapiens	0-10
10750596-14	1999	In conclusion, ACE inhibitors and amlodipine act synergistically to regulate myocardial oxygen consumption by modulating kinin-mediated nitric oxide release, and this combination of drugs may be useful in the treatment of heart failure.	Oxygen	88-94	angiotensin I converting enzyme	Homo sapiens	15-18
10498986-1	1999	Experiments on 25 intact dogs, 2 calves and clinical tests in 45 patients have shown that in the blood of the aorta or pulmonary vein leaving the lungs there is a rise in generation of active oxygen forms by leukocytes, their phagocytic activity, the activity of myeloperoxidase, NADPN-oxidase, complement, immunoglobulins content.	Oxygen	192-198	myeloperoxidase	Homo sapiens	263-278
10467859-1	1999	Presents the genetic aspects of haptoglobin in health, the rare types, and shifts of Hp fractions resultant from changes in the redox function (particularly in children) caused by high temperature, carbon monoxide, oxygen insufficiency, etc.	Oxygen	215-221	haptoglobin	Homo sapiens	32-43
10750596-3	1999	We investigated the possibility of synergy between ACE inhibitors and amlodipine in regulating myocardial oxygen consumption.	Oxygen	106-112	angiotensin I converting enzyme	Homo sapiens	51-54
10386999-5	1999	Spectrochemical techniques are used to show that molecular oxygen is then trapped by A beta and reduced to H2O2 in a reaction that is driven by substoichiometric amounts of Fe(II) or Cu(I).	Oxygen	59-65	amyloid beta precursor protein	Homo sapiens	85-91
10354503-3	1999	When EPO-producing Hep3B cells were incubated in 1% O2 (hypoxia) for 24 h, PMA treatment resulted in significant decreases in medium levels of EPO in Hep3B cell cultures at concentrations higher than 10 nM.	Oxygen	52-54	erythropoietin	Homo sapiens	5-8
10354503-3	1999	When EPO-producing Hep3B cells were incubated in 1% O2 (hypoxia) for 24 h, PMA treatment resulted in significant decreases in medium levels of EPO in Hep3B cell cultures at concentrations higher than 10 nM.	Oxygen	52-54	erythropoietin	Homo sapiens	143-146
10450606-3	1999	In the presence of dioxygen, the complex was converted to the well-characterized purple cluster species consisting of Cu+, Cu2+, and PS2-.	Oxygen	19-27	taste 2 receptor member 64 pseudogene	Homo sapiens	133-136
10403868-5	1999	The minimum inspired oxygen fraction measured with the remaining devices was greater than with the T-piece at an oxygen flow of 10 l.min-1.	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	133-138
10362508-7	1999	The oxygen patterns closely mimic those that have previously been reported for intracellular Ca2+ levels and are suggestive of an important role for Ca2+ in amplifying metabolic oscillations.	Oxygen	4-10	carbonic anhydrase 2	Mus musculus	149-152
10362686-0	1999	Increases in oxygen tension stimulate expression of ICAM-1 and VCAM-1 on human endothelial cells.	Oxygen	13-19	vascular cell adhesion molecule 1	Homo sapiens	63-69
10362686-5	1999	Subsequent rises in oxygen (21, 40, or 95% O2) led to marked increase of ICAM-1 and VCAM-1 cell surface and mRNA expression in both EC types, which after 16 h amounted to about one-third to one-half of maximal TNF-alpha-induced expression.	Oxygen	20-26	vascular cell adhesion molecule 1	Homo sapiens	84-90
10362686-5	1999	Subsequent rises in oxygen (21, 40, or 95% O2) led to marked increase of ICAM-1 and VCAM-1 cell surface and mRNA expression in both EC types, which after 16 h amounted to about one-third to one-half of maximal TNF-alpha-induced expression.	Oxygen	20-26	tumor necrosis factor	Homo sapiens	210-219
10362686-5	1999	Subsequent rises in oxygen (21, 40, or 95% O2) led to marked increase of ICAM-1 and VCAM-1 cell surface and mRNA expression in both EC types, which after 16 h amounted to about one-third to one-half of maximal TNF-alpha-induced expression.	Oxygen	43-45	vascular cell adhesion molecule 1	Homo sapiens	84-90
10362686-9	1999	Moreover, the oxygen-induced rise could be mimicked by addition of H2O2 to normoxic cells, and the oxygen-induced expression of VCAM-1 but not of ICAM-1 was inhibited by addition of the free radical scavengers superoxide dismutase, N-acetyl-L-cysteine, and pyrrolidinedithiocarbamate.	Oxygen	14-20	vascular cell adhesion molecule 1	Homo sapiens	128-134
10362686-9	1999	Moreover, the oxygen-induced rise could be mimicked by addition of H2O2 to normoxic cells, and the oxygen-induced expression of VCAM-1 but not of ICAM-1 was inhibited by addition of the free radical scavengers superoxide dismutase, N-acetyl-L-cysteine, and pyrrolidinedithiocarbamate.	Oxygen	99-105	vascular cell adhesion molecule 1	Homo sapiens	128-134
10362686-10	1999	These data indicate that an increase in oxygen availability stimulates ICAM-1 and VCAM-1 expression on micro- and macrovascular EC, which may contribute to adhesion and transmigration of different leukocyte populations in ischemia-reperfusion injuries.	Oxygen	40-46	vascular cell adhesion molecule 1	Homo sapiens	82-88
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	Oxygen	136-138	protein kinase C alpha	Homo sapiens	13-16
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	Oxygen	136-138	erythropoietin	Homo sapiens	83-86
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	Oxygen	136-138	erythropoietin	Homo sapiens	91-94
10354503-8	1999	The translocation of PKCalpha from the soluble to particulate fractions was increased in Hep3B cells incubated under hypoxia compared with normoxia (21% O2) controls.	Oxygen	153-155	protein kinase C alpha	Homo sapiens	21-29
10362508-7	1999	The oxygen patterns closely mimic those that have previously been reported for intracellular Ca2+ levels and are suggestive of an important role for Ca2+ in amplifying metabolic oscillations.	Oxygen	4-10	carbonic anhydrase 2	Mus musculus	93-96
10362799-7	1999	In this study, we demonstrate complete inhibition of retinal neovascularization in mice with oxygen-induced ischemic retinopathy by oral administration of a partially selective kinase inhibitor that blocks several members of the protein kinase C family, along with vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.	Oxygen	93-99	vascular endothelial growth factor A	Homo sapiens	265-299
10422630-9	1999	We found that sulphydryl oxidising agents exert a differential inhibitory effect on hypoxia-induced versus DFO-induced Epo production, providing further evidence that multiple pathways of oxygen sensing exist.	Oxygen	188-194	erythropoietin	Homo sapiens	119-122
10403868-5	1999	The minimum inspired oxygen fraction measured with the remaining devices was greater than with the T-piece at an oxygen flow of 10 l.min-1.	Oxygen	113-119	CD59 molecule (CD59 blood group)	Homo sapiens	133-138
10422630-0	1999	Erythropoietin production: evidence for multiple oxygen sensing pathways.	Oxygen	49-55	erythropoietin	Homo sapiens	0-14
10422630-7	1999	Iron chelation stimulates Epo production at 20% O2 and enhances Epo production at 1% O2, but it has no additive effect on cobalt-induced Epo production.	Oxygen	48-50	erythropoietin	Homo sapiens	26-29
10356310-0	1999	Regulation of erythropoietin gene expression depends on two different oxygen-sensing mechanisms.	Oxygen	70-76	erythropoietin	Homo sapiens	14-28
10454125-10	1999	In addition, by elevating oxygen consumption in the brain, UCP2 could in specific regions control the production of reactive oxygen species and thereby influence the process of neural degeneration.	Oxygen	26-32	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	59-63
10353251-9	1999	These findings indicate that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF alpha-subunits.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
10360361-1	1999	Here we present cryoelectron crystallographic analysis of an isolated dimeric oxygen-evolving complex of photosystem II (at a resolution of approximately 0.9 nm), revealing that the D1-D2 reaction center (RC) proteins are centrally located between the chlorophyll-binding proteins, CP43 and CP47.	Oxygen	78-84	beaded filament structural protein 2	Homo sapiens	291-295
10378001-3	1999	Our results are consistent with the conclusions of previous studies indicating that hypericin binds to HSA by means of a specific hydrogen-bonded interaction between its carbonyl oxygen and the N1-H of the tryptophan residue in the IIA subdomain of HSA.	Oxygen	179-185	albumin	Homo sapiens	103-106
10513071-7	1999	A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio.	Oxygen	127-133	interleukin 6	Homo sapiens	24-37
10328919-1	1999	Hypoxia-inducible factor 1 (HIF-1) is a dimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits that plays an essential role in mammalian O2 homeostasis.	Oxygen	157-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10353251-11	1999	The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-14
10328919-1	1999	Hypoxia-inducible factor 1 (HIF-1) is a dimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits that plays an essential role in mammalian O2 homeostasis.	Oxygen	157-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10328919-7	1999	In tissue culture cells, VEGF mRNA expression was induced by glucose deprivation independent of HIF-1alpha, providing a mechanism for increased VEGF mRNA expression in Hif1a-/- embryos, in which absence of adequate tissue perfusion resulted in both O2 and glucose deprivation.	Oxygen	249-251	vascular endothelial growth factor A	Homo sapiens	25-29
10320748-4	1999	In the wild-type, expression of the heat shock protein genes, hsp16-1 and hsp16-48, increased dramatically after incubation under high oxygen.	Oxygen	135-141	Heat shock protein 110	Caenorhabditis elegans	36-54
10463102-3	1999	These cells responded to fMLP or PAF (1 microM each) with an increase in [Ca2+]i (217.3 +/- 22.1 and 197.8 +/- 22.1 nM respectively) which was associated with production of O2- (40.2 +/- 8.2 and 35.2 +/- 7.6 pmol/min/10(6) cells respectively).	Oxygen	173-175	formyl peptide receptor 1	Homo sapiens	25-29
10329601-3	1999	In the present study, mice were treated with the recombinant human KGF intravenously before (days -2 and -1) or during (days 0 and +1) oxygen exposure.	Oxygen	135-141	fibroblast growth factor 7	Homo sapiens	67-70
10330014-5	1999	min-1, intra-SMA) reduced oxygen consumption by 25.1 +/- 2.9 from 73.1 +/- 10.8 micromol.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
10223943-9	1999	We conclude that (i) the control exerted by gamma interferon on intracellular multiplication of Listeria in THP-1 macrophages is dependent on the production of nitric oxide and hydrogen peroxide; (ii) intracellular Listeria may become insensitive to ampicillin in macrophages exposed to gamma interferon because the increase in reactive oxygen and nitrogen intermediates already controls bacterial growth; and (iii) azithromycin and still more sparfloxacin cooperate efficiently with gamma interferon, one of the main cellular host defenses in Listeria infection.	Oxygen	337-343	GLI family zinc finger 2	Homo sapiens	108-113
10332951-9	1999	Heart rate and oxygen consumption increased 75+/-4 bpm and 26.3+/-1.4 ml O2/kg x min(-1) from supine resting values, respectively.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
10332951-9	1999	Heart rate and oxygen consumption increased 75+/-4 bpm and 26.3+/-1.4 ml O2/kg x min(-1) from supine resting values, respectively.	Oxygen	73-75	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
11593517-1	1999	OBJECTIVE: To observe the effects of nerve growth factor (NGF) on nitric oxide (NO) release and constitutive nitric oxide synthase (cNOS) gene expression in oxygen/glucose deprived cortical neuron cultures.	Oxygen	157-163	nitric oxide synthase 3	Homo sapiens	132-136
10463102-5	1999	Removal or chelation of extracellular Ca2+ induced a reduction of both the fMLP and PAF-induced [Ca2+]i rise and O2- production.	Oxygen	113-115	formyl peptide receptor 1	Homo sapiens	75-79
10463102-7	1999	SK&amp;F 96365 had a stimulatory effect on PAF-induced [Ca2+]i rise and on fMLP-induced O2- production, this phenomenon was not observed with extracellular Ca2+ removal or chelation.	Oxygen	88-90	formyl peptide receptor 1	Homo sapiens	75-79
10463102-8	1999	Furthermore, Ni2+ exhibited an inhibition of both fMLP and PAF-induced [Ca2+]i rise and O2- production.	Oxygen	88-90	formyl peptide receptor 1	Homo sapiens	50-54
10463102-10	1999	Our results indicate that fMLP and PAF dependent O2- production in human eosinophils require intra- and extracellular Ca2+ and that Ca2+ influx is necessary for optimal activation.	Oxygen	49-51	formyl peptide receptor 1	Homo sapiens	26-30
10446756-5	1999	Active oxygen scavengers such as superoxide dismutase and catalase effectively blocked the formation of 8-OHdG in culture medium, and deferoxamine, which inhibits hydroxyl radicals production by chelating iron, was also effective in inhibiting the DEP-produced 8-OHdG formation.	Oxygen	7-13	catalase	Mus musculus	58-66
10432009-1	1999	We previously reported that reactive oxygen species (ROS) enhance tumor cell metastasis, and by administration of recombinant human superoxide dismutase (rh SOD), an enzyme which scavenges O2- successfully reduced lung metastasis of mouse MethA sarcoma and Lewis lung carcinoma.	Oxygen	189-191	superoxide dismutase 1	Homo sapiens	157-160
10432009-2	1999	These observations suggested that rh SOD suppressed tumor cell invasion by eliminating O2- the primary source of ROS.	Oxygen	87-89	superoxide dismutase 1	Homo sapiens	37-40
10217759-4	1999	The rate of benzene-dependent O2 consumption decreased with time, but it was partially increased by the addition of catalase in the course of the O2 consumption by NDO.	Oxygen	146-148	catalase	Homo sapiens	116-124
10212290-1	1999	This work determined Ca2+ transport processes that contribute to the rise in cytosolic Ca2+ during in vitro ischemia (deprivation of oxygen and glucose) in the hippocampus.	Oxygen	133-139	carbonic anhydrase 2	Rattus norvegicus	21-24
10212290-1	1999	This work determined Ca2+ transport processes that contribute to the rise in cytosolic Ca2+ during in vitro ischemia (deprivation of oxygen and glucose) in the hippocampus.	Oxygen	133-139	carbonic anhydrase 2	Rattus norvegicus	87-90
10319084-7	1999	Pharmacologic inhibition of AII production likely conveys myocardial and vascular protection in situations of acute myocardial oxygen debt.	Oxygen	127-133	angiotensinogen	Homo sapiens	28-31
10207038-5	1999	The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo).	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-13
10382860-1	1999	We have recently demonstrated that inducible nitric oxide synthase (iNOS) is expressed in rat forebrain slices exposed to oxygen and glucose deprivation (OGD).	Oxygen	122-128	nitric oxide synthase 2	Rattus norvegicus	35-66
10382860-1	1999	We have recently demonstrated that inducible nitric oxide synthase (iNOS) is expressed in rat forebrain slices exposed to oxygen and glucose deprivation (OGD).	Oxygen	122-128	nitric oxide synthase 2	Rattus norvegicus	68-72
10233113-2	1999	We further hypothesized that an increased exercise SaO2 with AA exposure would enhance O2 transport and improve both peak O2 uptake (VO2 peak; ml x kg-1 x min-1) and submaximal exercise time to exhaustion (Exh; min) in the midluteal phase.	Oxygen	53-55	CD59 molecule (CD59 blood group)	Homo sapiens	155-160
10344393-7	1999	Follow-up examinations have demonstrated that partial correction of anaemia with recombinant Epo can improve cardiac oxygen supply and partially reverse pathological changes in left ventricular geometry.	Oxygen	117-123	erythropoietin	Homo sapiens	93-96
10226334-2	1999	Increased NO from inducible nitric oxide synthase (iNOS) occurs in acute immune glomerulonephritis (GN), in which rapid induction probably depends on local cytokines and/or oxygen radical production.	Oxygen	173-179	nitric oxide synthase 2	Homo sapiens	18-49
10226334-2	1999	Increased NO from inducible nitric oxide synthase (iNOS) occurs in acute immune glomerulonephritis (GN), in which rapid induction probably depends on local cytokines and/or oxygen radical production.	Oxygen	173-179	nitric oxide synthase 2	Homo sapiens	51-55
10212278-0	1999	Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments.	Oxygen	84-90	dual specificity phosphatase 1	Homo sapiens	0-46
10212278-0	1999	Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments.	Oxygen	84-90	dual specificity phosphatase 1	Homo sapiens	48-53
10207038-5	1999	The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo).	Oxygen	140-146	erythropoietin	Homo sapiens	153-167
10207038-5	1999	The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo).	Oxygen	140-146	erythropoietin	Homo sapiens	169-172
10202154-1	1999	Hypoxia-inducible factor 1 alpha (HIF1alpha) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
10095044-4	1999	On the other hand, superoxide dismutase (SOD), catalase and deferoxamine (DFX), which have inhibitory effects on the generation of O2-, H2O2 and hydroxyl radicals, respectively, protected the neurons.	Oxygen	131-134	catalase	Homo sapiens	47-55
10455828-0	1999	The effect of oxygen on propofol-induced inhibition of microsomal cytochrome P450 3A4.	Oxygen	14-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-85
10455827-5	1999	Dopexamine produced a significant increase in oxygen delivery (infusion 548 ml O2.min-1.m-2; no infusion 492 ml O2.min-1.m-2) while prostacyclin caused a decrease (infusion 460 ml O2.min-1.m-2; no infusion 547 ml O2.min-1.m-2).	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
10223197-7	1999	NADPH enhanced AP-1 activation by increasing vanadate-mediated generation of O2-*.	Oxygen	77-79	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
10223197-12	1999	SOD inhibited the ESR spin adduct signal, further demonstrating the generation of O2-* in the cellular reduction of vanadate.	Oxygen	82-84	superoxide dismutase 1	Homo sapiens	0-3
10202154-1	1999	Hypoxia-inducible factor 1 alpha (HIF1alpha) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen.	Oxygen	156-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-43
10231349-4	1999	RESULTS: Unlike LCT and SL, LCT/MCT increased PMA- and STZ-induced oxygen uptake rate by 45% and 31% respectively (both P = 0.006 compared with medium) as well as superoxide (+56%, P = 0.006) and hydrogen peroxide (+14%, P = 0.04) production, within 5 min after stimulation.	Oxygen	67-73	solute carrier family 16 member 1	Homo sapiens	32-35
10202154-1	1999	Hypoxia-inducible factor 1 alpha (HIF1alpha) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen.	Oxygen	156-162	erythropoietin	Homo sapiens	122-136
10201010-8	1999	Induction of apoptosis by oxLDL and oxLp(a) in RA was enhanced by the superoxide dismutase (SOD) inhibitor, diethyl-dithio-carbamate, and was blunted by SOD and catalase in HUVECs and RA, suggesting that O2- formation was involved.	Oxygen	204-206	superoxide dismutase 1	Homo sapiens	92-95
10499085-1	1999	Photoexcited iron porphyrins can be used to mimic the catalytic activity of cytochrome P-450 oxygenases both in the reduction of halogenated alkanes and in the oxidation of hydrocarbons by O2 itself at room temperature and atmospheric pressure.	Oxygen	189-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-92
10200222-12	1999	When Ca2+-free (0 mM) with Co2+ (2.5 mM)-containing medium including oxygen and glucose was applied within 1 min after the rapid depolarization, the membrane potential was restored completely to the preexposure level in the majority of neurons.	Oxygen	69-75	carbonic anhydrase 2	Rattus norvegicus	5-8
10201010-8	1999	Induction of apoptosis by oxLDL and oxLp(a) in RA was enhanced by the superoxide dismutase (SOD) inhibitor, diethyl-dithio-carbamate, and was blunted by SOD and catalase in HUVECs and RA, suggesting that O2- formation was involved.	Oxygen	204-206	catalase	Homo sapiens	161-169
10394824-2	1999	Hypoxaemia, reduced blood oxygen-carrying capacity and increased affinity of haemoglobin (Hb) for oxygen are the primary stimuli for EPO secretion.	Oxygen	26-32	erythropoietin	Homo sapiens	133-136
10394824-3	1999	The effect of hyperoxaemia (arterial oxygen tension (Pa,O2) &gt; 13.3 kPa) on EPO secretion has not been thoroughly studied and is not fully understood.	Oxygen	56-58	erythropoietin	Homo sapiens	78-81
10394824-2	1999	Hypoxaemia, reduced blood oxygen-carrying capacity and increased affinity of haemoglobin (Hb) for oxygen are the primary stimuli for EPO secretion.	Oxygen	98-104	erythropoietin	Homo sapiens	133-136
10394824-3	1999	The effect of hyperoxaemia (arterial oxygen tension (Pa,O2) &gt; 13.3 kPa) on EPO secretion has not been thoroughly studied and is not fully understood.	Oxygen	37-43	erythropoietin	Homo sapiens	78-81
10203153-6	1999	We have found that activated clotting and t-PA plasma concentrations are positively correlated with arterial-to-alveolar oxygen tension ratio and ventilator efficiency index values.	Oxygen	121-127	plasminogen activator, tissue type	Homo sapiens	42-46
10198110-1	1999	4-Hydroxyphenylpyruvate dioxygenase (4HPPD) catalyzes the formation of homogentisate (2,5-dihydroxyphenylacetate) from p-hydroxyphenylpyruvate and molecular oxygen.	Oxygen	26-32	4-hydroxyphenylpyruvate dioxygenase	Arabidopsis thaliana	37-42
10385037-2	1999	It is likely that cells from a wide variety of tissues share a common mechanism of oxygen sensing and signal transduction leading to the activation of the transcription factor hypoxia-inducible factor 1 (HIF-1).	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-202
10085255-1	1999	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10085255-1	1999	Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
10385037-2	1999	It is likely that cells from a wide variety of tissues share a common mechanism of oxygen sensing and signal transduction leading to the activation of the transcription factor hypoxia-inducible factor 1 (HIF-1).	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	204-209
10385037-6	1999	The activation of HIF-1 by hypoxia depends upon signaling-dependent rescue of its alpha-subunit from oxygen-dependent degradation in the proteasome, allowing it to form a heterodimer with HIF-1beta (ARNT), which then translocates to the nucleus and impacts on the transcription of genes whose cis-acting elements contain cognate hypoxia response elements.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
10090785-4	1999	Replacement of the oxygen in the chromenone ring of 6 by a nitrogen atom further improved the inhibitory activity against the EGFR kinase.	Oxygen	19-25	epidermal growth factor receptor	Homo sapiens	126-130
10085090-2	1999	S100A8 may be exposed to oxygen metabolites, particularly hypochlorite, the major oxidant generated by activated neutrophils at inflammatory sites.	Oxygen	25-31	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	0-6
10100854-4	1999	could theoretically inhibit the oxygen consumption with continued ATP synthesis, by acting as an electron acceptor from cytochrome c or as a terminal electron acceptor in stead of oxygen.	Oxygen	32-38	cytochrome c, somatic	Homo sapiens	120-132
10085152-9	1999	Moreover, both NO and CO specifically targeted the internal oxygen-dependent degradation domain of HIF-1alpha, and also repressed the C-terminal transactivation domain of HIF-1alpha.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
10077670-1	1999	It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species.	Oxygen	226-232	superoxide dismutase 1	Homo sapiens	134-137
10385054-5	1999	Levels of reactive oxygen species, expressed as the slope of the relative fluorescence of a radical-reactive fluorochrome, in the cells from familial ALS patients with SOD-1 gene mutations (2.14+/-1.06 Gy(-1)) and patients with sporadic ALS (1.38+/-0.21 Gy(-1)) were not significantly different from the controls (1.54+/-0.39 Gy(-1)).	Oxygen	19-25	superoxide dismutase 1	Homo sapiens	168-173
10192175-0	1999	Blood oxygen partial pressure affects plasma prolactin concentration in humans.	Oxygen	6-12	prolactin	Homo sapiens	45-54
16599868-3	1999	SUMMARY OF REVIEW: The P50 of a species is determined by natural selection according to animal size, tissue metabolic requirements and ambient oxygen tension.	Oxygen	143-149	nuclear factor kappa B subunit 1	Homo sapiens	23-26
10103001-9	1999	The .OH-producing activity of horseradish peroxidase can be inhibited by inactivators of haem iron or by various O2.- and .OH scavengers.	Oxygen	113-115	peroxidase	Glycine max	42-52
10103001-4	1999	Here we show that horseradish peroxidase can also catalyze a third type of reaction that results in the production of hydroxyl radicals (.OH) from H2O2 in the presence of O2.-.	Oxygen	149-151	peroxidase	Glycine max	30-40
10103001-5	1999	We provide evidence that to mediate this reaction, the ferric form of horseradish peroxidase must be converted by O2.- into the perferryl form (Compound III), in which the haem iron can assume the ferrous state.	Oxygen	114-116	peroxidase	Glycine max	82-92
10103001-6	1999	It is concluded that the ferric/perferryl peroxidase couple constitutes an effective biochemical catalyst for the production of .OH from O2.- and H2O2 (iron-catalyzed Haber-Weiss reaction).	Oxygen	137-139	peroxidase	Glycine max	42-52
10103001-8	1999	O2.- and H2O2 can be produced by the oxidase reaction of horseradish peroxidase in the presence of NADH.	Oxygen	0-2	peroxidase	Glycine max	69-79
10192175-1	1999	Responses of plasma prolactin (PRL) concentration to acute and repeated changes in blood oxygen partial pressure (PO2a) at rest were investigated in two studies (A; B), with special reference to possible effects mediated via serotonin (5-HT) synthesis.	Oxygen	89-95	prolactin	Homo sapiens	20-29
10192175-1	1999	Responses of plasma prolactin (PRL) concentration to acute and repeated changes in blood oxygen partial pressure (PO2a) at rest were investigated in two studies (A; B), with special reference to possible effects mediated via serotonin (5-HT) synthesis.	Oxygen	89-95	prolactin	Homo sapiens	31-34
10026353-14	1999	Thus, ET-1 might be a marker of a disequilibrium between myocardial oxygen demand and coronary blood flow in IDCM.	Oxygen	68-74	endothelin 1	Homo sapiens	6-10
10089906-12	1999	CD34+ marrow cells from normal donors were also grown under variable oxygen tension, and the cell proliferation in 5% oxygen was significantly greater at both 7 and 14 days of culture.	Oxygen	118-124	CD34 molecule	Homo sapiens	0-4
10078877-4	1999	The baseline whole-brain oxygen consumption averaged 185 +/- 32 micromol hg(-1) min(-1) by the three-step method and 153 +/- 15 micromol hg(-1) min(-1) by the one-step method.	Oxygen	25-31	CD59 molecule (CD59 blood group)	Homo sapiens	80-86
10207985-4	1999	In the rats exposed to CO2/O2 or CO2, leukocyte counts, lymphocyte counts, and glucose values were higher, and aspartate aminotransferase, creatine kinase, and calcium values were lower compared with those of rats exposed to room air only.	Oxygen	24-26	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	111-137
10365597-6	1999	The treatment with oxygen-ozone therapy caused in patients slight statistically not significant raise of t-PA and vWF antigen showing the endothelial stimulation but not the destruction of vascular endothelium.	Oxygen	19-25	plasminogen activator, tissue type	Homo sapiens	105-109
10365597-6	1999	The treatment with oxygen-ozone therapy caused in patients slight statistically not significant raise of t-PA and vWF antigen showing the endothelial stimulation but not the destruction of vascular endothelium.	Oxygen	19-25	von Willebrand factor	Homo sapiens	114-117
10064726-8	1999	Estradiol (65 pg/ml) and alpha-tocopherol (6 mg/L) both attenuated TNF-mediated LDL accumulation (P &lt; 0.05), indicating that TNF may exert its effects on LDL accumulation through cellular production of oxygen-derived free radicals.	Oxygen	205-211	tumor necrosis factor	Homo sapiens	128-131
10232875-5	1999	RESULTS: When the cells were cultured with LPS, IL-6, and TNF-alpha but not IL-1beta, ATP levels increased significantly at 6 h, followed by a decrease at 24 h. Enhancement of oxygen consumption, which was completely blocked by antimycin A, was also shown at 3 h by the exposure to these substrates.	Oxygen	176-182	interleukin 6	Homo sapiens	48-52
10232875-5	1999	RESULTS: When the cells were cultured with LPS, IL-6, and TNF-alpha but not IL-1beta, ATP levels increased significantly at 6 h, followed by a decrease at 24 h. Enhancement of oxygen consumption, which was completely blocked by antimycin A, was also shown at 3 h by the exposure to these substrates.	Oxygen	176-182	tumor necrosis factor	Homo sapiens	58-67
10211608-3	1999	In the present study, we investigated interleukin (IL)-1beta-induced oxygen free radical production and the role of oxygen free radicals in IL-1beta-induced GAG production in retro-ocular fibroblasts from both normal subjects and patients with GO.	Oxygen	69-75	interleukin 1 beta	Homo sapiens	38-60
10027302-10	1999	The content of 8-hydroxydeoxyguanosine (8-OHdG) by which the cellular DNA damage caused by active oxygen species can be assessed was significantly low in the tumours arising from the QR clone with high levels of Mn-SOD and GPchi even if the clone had been co-implanted with gelatin sponge, compared with the arising tumour from the QR clone with low levels of those antioxidative enzymes (P&lt;0.001).	Oxygen	98-104	superoxide dismutase 2, mitochondrial	Mus musculus	212-218
10083814-3	1999	Epo producing cells in the kidney sense the O2 tension of kidney tissue and react to hypoxia with increased Epo production and to O2 saturation (polycythaemia) with decreased or completely abolished Epo production.	Oxygen	44-46	erythropoietin	Homo sapiens	0-3
10083814-3	1999	Epo producing cells in the kidney sense the O2 tension of kidney tissue and react to hypoxia with increased Epo production and to O2 saturation (polycythaemia) with decreased or completely abolished Epo production.	Oxygen	130-132	erythropoietin	Homo sapiens	0-3
10050881-0	1999	Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.	Oxygen	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
10050881-9	1999	Since intratumoral augmentation of IL-8 and VEGF secretion, following microenvironmental decreases in oxygen pressure, may promote angiogenesis, further definition of these pathways is essential to appropriately target them for antitumoral therapy.	Oxygen	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
10368284-8	1999	CONCLUSIONS: The structure shows how large ligands containing PC may be bound by CRP via a phosphate oxygen that projects away from the surface of the protein.	Oxygen	101-107	C-reactive protein	Homo sapiens	81-84
10190578-5	1999	DT-Diaphorase is known to promote the redox cycling of 2-hydroxy-1,4-naphthoquinone in vitro, with concomitant formation of "active oxygen" species.	Oxygen	132-138	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	0-13
10068204-4	1999	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in VEGF and PIGF expression and function.	Oxygen	50-56	vascular endothelial growth factor A	Homo sapiens	164-168
9927288-1	1999	The most important stimulus for the enhanced synthesis of erythropoietin (Epo) is a lowered O2 tension in the tissue.	Oxygen	92-94	erythropoietin	Homo sapiens	58-72
9927288-1	1999	The most important stimulus for the enhanced synthesis of erythropoietin (Epo) is a lowered O2 tension in the tissue.	Oxygen	92-94	erythropoietin	Homo sapiens	74-77
9927288-2	1999	However, the mechanism by which an impaired O2 supply is transduced into appropriate Epo production is still not fully understood.	Oxygen	44-46	erythropoietin	Homo sapiens	85-88
9927288-3	1999	Recently, studies in human hepatoma cells (line HepG2) indicate that reactive O2 species are involved in the signal transduction from the cellular O2 sensor to the Epo gene.	Oxygen	78-80	erythropoietin	Homo sapiens	164-167
9927495-3	1999	We show that gelsolin-null neurons have enhanced cell death and rapid, sustained elevation of Ca2+ levels following glucose/oxygen deprivation, as well as augmented cytosolic Ca2+ levels in nerve terminals following depolarization in vitro.	Oxygen	124-130	gelsolin	Mus musculus	13-21
9927288-10	1999	Our data strongly support the idea that reactive O2 species, especially H2O2, are part of the signaling chain of the cellular O2-sensing mechanism regulating the renal synthesis of Epo.	Oxygen	49-51	erythropoietin	Homo sapiens	181-184
10068204-4	1999	We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in VEGF and PIGF expression and function.	Oxygen	50-56	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	173-177
10068204-8	1999	In vitro studies demonstrated that increasing oxygen tension (hyperoxia) up-regulated PIGF protein in term placental villous explants, whereas hypoxic culture of a term trophoblast choriocarcinoma cell line (BeWo) down-regulated PIGF mRNA and protein and VEGFR-1 (Flt-1) autophosphorylation.	Oxygen	46-52	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	86-90
10190572-16	1999	These results showed that N,N"-substituted alkylthioureas were capable of inducing mEH and rGSTA2 in the liver with elevation of the mRNAs, that induction of mEH and rGSTA2 by these alkylthioureas might be mediated by production of the reactive oxygens derived from metabolic activation of the agents irrespective of their radical scavenging effect and that the agents rather enhanced toxicant-induced liver injury with the induction of P450 2E1 or P450 2B1/2.	Oxygen	245-252	epoxide hydrolase 1, microsomal	Mus musculus	83-86
18967474-0	1999	A novel biosensor for specific determination of hydrogen peroxide: catalase enzyme electrode based on dissolved oxygen probe.	Oxygen	112-118	catalase	Homo sapiens	67-75
9989595-0	1999	Physiological production of singlet molecular oxygen in the myeloperoxidase-H2O2-chloride system.	Oxygen	28-52	myeloperoxidase	Homo sapiens	60-75
10190572-16	1999	These results showed that N,N"-substituted alkylthioureas were capable of inducing mEH and rGSTA2 in the liver with elevation of the mRNAs, that induction of mEH and rGSTA2 by these alkylthioureas might be mediated by production of the reactive oxygens derived from metabolic activation of the agents irrespective of their radical scavenging effect and that the agents rather enhanced toxicant-induced liver injury with the induction of P450 2E1 or P450 2B1/2.	Oxygen	245-252	epoxide hydrolase 1, microsomal	Mus musculus	158-161
10217667-10	1999	High ICAM-1 levels and low TGF beta 1 levels in lung fluid are related to oxygen dependency at 28 days of age.	Oxygen	74-80	transforming growth factor beta 1	Homo sapiens	27-37
9882464-10	1999	Thus, at the relatively low in vivo oxygen concentrations, SIN-1 is likely to behave more like an *NO donor than a peroxynitrite donor.	Oxygen	36-42	MAPK associated protein 1	Homo sapiens	59-64
9920739-2	1999	Plasma levels of Et1 were elevated 2-fold while levels of nitrate, a NO metabolite, decreased in rats exposed to 10 days of hypoxia (10% O2).	Oxygen	137-139	endothelin 1	Rattus norvegicus	17-20
9873013-6	1999	UV-visible absorbance (UV-Vis), magnetic circular dichroism (MCD), and electron paramagnetic resonance (EPR) spectra indicate that TXAS has a typical low spin cytochrome P450 heme with an oxygen-based distal ligand.	Oxygen	188-194	thromboxane A synthase 1	Homo sapiens	131-135
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Oxygen	150-152	nitric oxide synthase 2	Homo sapiens	0-40
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Oxygen	150-152	nitric oxide synthase 2	Homo sapiens	42-46
10659127-2	1999	Many investigators do this with the classical laboratory animal, the rat, but it has a quite different oxygen pressure of half saturation (p50 = 36 mmHg) from that of humans (26 mmHg).	Oxygen	103-109	neuronal pentraxin-2	Cavia porcellus	139-142
9990287-7	1999	Using gel shift analysis, we documented in O2-treated cells an increased binding to the four NF-kappa B binding sites.	Oxygen	43-45	nuclear factor kappa B subunit 1	Homo sapiens	93-103
10535326-5	1999	The biology of the von Hippel-Lindau gene and its normal function continued to be unravelled but a role has been demonstrated for it in the regulation of gene transcription, the regulation of oxygen-dependent genes and their expression and the control of tumour angiogenesis acting via the vascular endothelial growth factor.	Oxygen	192-198	vascular endothelial growth factor A	Homo sapiens	290-324
9887062-17	1999	Whole lung KGF mRNA expression was increased 12-fold after 6 days of hyperoxia compared with control lungs, and remained increased throughout the 100% O2 exposure period.	Oxygen	151-153	fibroblast growth factor 7	Oryctolagus cuniculus	11-14
9870913-6	1999	VEGF protein and mRNA were increased by the maintenance of human fetal lung explants in 2% O2 environments compared with 20% O2 environments.	Oxygen	91-93	vascular endothelial growth factor A	Homo sapiens	0-4
9870913-6	1999	VEGF protein and mRNA were increased by the maintenance of human fetal lung explants in 2% O2 environments compared with 20% O2 environments.	Oxygen	125-127	vascular endothelial growth factor A	Homo sapiens	0-4
9870913-7	1999	VEGF mRNA levels were found to be increased by cyclic adenosine monophosphate (cAMP) in explants that were incubated in 20% O2, but not in those incubated in 2% O2.	Oxygen	124-126	vascular endothelial growth factor A	Homo sapiens	0-4
9870913-7	1999	VEGF mRNA levels were found to be increased by cyclic adenosine monophosphate (cAMP) in explants that were incubated in 20% O2, but not in those incubated in 2% O2.	Oxygen	161-163	vascular endothelial growth factor A	Homo sapiens	0-4
9870913-9	1999	Immunostaining for VEGF increased with incubation of human fetal lung explants in 2% and 20% O2.	Oxygen	93-95	vascular endothelial growth factor A	Homo sapiens	19-23
9870913-11	1999	Incubation of tissues in the presence of dibutyryl cAMP resulted in an increase in immunostaining for VEGF, primarily in the basement membranes of prealveolar ducts in 20% O2-treated tissues.	Oxygen	172-174	vascular endothelial growth factor A	Homo sapiens	102-106
9870913-13	1999	These data suggest that VEGF gene expression is regulated by both oxygen and cAMP in the developing human lung.	Oxygen	66-72	vascular endothelial growth factor A	Homo sapiens	24-28
10611972-0	1999	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	Oxygen	24-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-68
10611972-2	1999	HIF-1 alpha expression and HIF-1 transcriptional activity increase exponentially as cellular O2 concentration is decreased.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
10611972-2	1999	HIF-1 alpha expression and HIF-1 transcriptional activity increase exponentially as cellular O2 concentration is decreased.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
10611972-8	1999	HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology.	Oxygen	56-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
10075275-6	1999	Investigation of a potential underlying mechanism of anti-enterococcal action of IFN-gamma reveals that it is, most probably, largely due to an activated secretion of the microbicidal reactive oxygen intermediates by neutrophils.	Oxygen	193-199	interferon gamma	Homo sapiens	81-90
9870913-10	1999	Interestingly, VEGF protein was localized primarily in the basement membrane subjacent to airway epithelial cells after 4 d of incubation in 20% O2.	Oxygen	145-147	vascular endothelial growth factor A	Homo sapiens	15-19
10440237-7	1999	The recent observations that changes in oxygen tension regulate both IRP1 and IRP2 RNA binding activities will be addressed in light of ROS regulation of the IRPs.	Oxygen	40-46	iron responsive element binding protein 2	Homo sapiens	78-82
10364736-7	1999	On the other hand, there was a significant negative correlation between plasma ET-1 level and mixed venous oxygen tension (r = -0.	Oxygen	107-113	endothelin 1	Homo sapiens	79-83
9935026-9	1999	RESULTS: Expression of iNOS was significantly increased in CHF (4.0+/-2.8 vs. 0.8+/-0.7% iNOS positive tissue area, p &lt; 0.001 vs. C) and inversely correlated to maximal oxygen uptake (r=-0.65, p &lt; 0.001).	Oxygen	172-178	nitric oxide synthase 2	Homo sapiens	23-27
10426227-10	1999	Although the release of reactive oxygen species and molecular oxygen occur around an implanted biomaterial, several oxidative systems (peroxidase, xanthine oxidase, catalase), known to produce one or more of these molecular species, were unable to induce radiolabel release from these PUs.	Oxygen	33-39	catalase	Homo sapiens	165-173
10419182-0	1999	Vitamin E inhibition of O2*- production in the promonocyte cell line THP-1 is essentially due to RRR-delta-tocopherol.	Oxygen	24-26	GLI family zinc finger 2	Homo sapiens	69-74
10100095-5	1999	Changes in endothelin-1 levels were correlated with changes in mean arterial pressure (r = 0.44, P &lt; 0.02) and with changes in oxygen saturation (r = 0.37, P &lt; 0.05).	Oxygen	130-136	endothelin 1	Homo sapiens	11-23
10897806-4	1999	The morpholinosydnonimine (SIN-1) the specific donor of NO and O2 only slightly reduces Cys and GSH in brain stems and ROS and SS remain at the control levels.	Oxygen	63-65	MAPK associated protein 1	Homo sapiens	27-32
10364736-11	1999	Oxygen administration significantly decreased plasma ET-1 levels at rest (p &lt; 0.05).	Oxygen	0-6	endothelin 1	Homo sapiens	53-57
10364738-8	1999	Peak oxygen consumption rose from 573 +/- 84 to 750 +/- 59 ml x min-1, corresponding to an increase in cardiac index from 4.25 +/- 0.5 to 5.88 +/- 0.76 liters x min-1 x m-2.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
10364738-8	1999	Peak oxygen consumption rose from 573 +/- 84 to 750 +/- 59 ml x min-1, corresponding to an increase in cardiac index from 4.25 +/- 0.5 to 5.88 +/- 0.76 liters x min-1 x m-2.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	161-166
10554331-3	1999	Because the inhibition of mitochondrial respiration by rotenone or antimycin A suppressed the increased oxidation of both dihydrorhodamine 123 and hydroethidine, it was suggested that TNF-alpha accelerated the leakage of reactive oxygen intermediates from the mitochondrial electron transport system.	Oxygen	230-236	tumor necrosis factor	Mus musculus	184-193
10399802-5	1999	Consecutive 10 min infusions of ET-1 at 1, 5, 10 and 15 ng/kg/min into the pulmonary artery decreased cardiac output (by 32%) and stroke volume (by 33%) and increased the systemic vascular resistance (by 62%) and arteriovenous oxygen difference (by 83%) at the highest dose.	Oxygen	227-233	endothelin 1	Homo sapiens	32-36
9852050-13	1998	These results suggest that reduced FAD of succinate dehydrogenase is the electron donor for oxygen to produce O-2 in the absence of their immediate electron acceptor and in the presence of cytochrome c.	Oxygen	92-98	cytochrome c, somatic	Homo sapiens	189-201
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	Oxygen	128-130	interleukin 1 beta	Homo sapiens	33-42
10226494-4	1999	The course of the ozone-oxygen irrigations produced good results: ear discharge and tympanic mucosa inflammation stopped in 81% of the irrigated patients, levels of myeloperoxidase which marks inflammation reduced significantly, bactericidal effects of the mixture were observed for all the detected pathogens, antibiotic sensitivity of the bacteria rose.	Oxygen	24-30	myeloperoxidase	Homo sapiens	165-180
9886730-8	1998	Peak oxygen consumption (ml x min(-1) x kg(-1)) was significantly increased in both the training (16.8+/-4.9 to 25.3+/-6.9) and non-training groups (16.3+/-5.1 to 19.6+/-6.0) 3 months after percutaneous balloon mitral valvuloplasty.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	30-36
9865721-1	1998	Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential.	Oxygen	0-6	tumor protein p53	Homo sapiens	69-72
9865721-1	1998	Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential.	Oxygen	0-6	tumor protein p53	Homo sapiens	105-108
9836634-0	1998	Oxygen isotope exchange between refractory inclusion in allende and solar nebula Gas A calcium-aluminum-rich inclusion (CAI) from the Allende meteorite was analyzed and found to contain melilite crystals with extreme oxygen-isotope compositions ( approximately 5 percent oxygen-16 enrichment relative to terrestrial oxygen-16).	Oxygen	0-6	PAXIP1 associated glutamate rich protein 1	Homo sapiens	81-84
10358750-3	1998	Although not fully understood, possible explanation for this phenomenon may be provided by a lowered interferon (IFN) output and increased cell replication which is often optimal at physiological oxygen tension.	Oxygen	196-202	interferon alpha 1	Homo sapiens	101-111
9847266-21	1998	min-1 dramatically increases PaO2 without apparent deleterious effect allowing a rapid reduction in inspired fraction of O2.	Oxygen	31-33	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
10052723-4	1998	Cell membrane-associated regulators of complement, membrane cofactor protein (CD46), decay-accelerating factor (CD55) and protectin (CD59) were expressed on EA.hy 926 cells grown under normal oxygen tension.	Oxygen	192-198	CD59 molecule (CD59 blood group)	Homo sapiens	133-137
9817920-2	1998	About 20% of familial cases are associated with mutations in the gene for copper/zinc superoxide dismutase ( SOD1 ), which catalyses the dismutation of the superoxide radical to hydrogen peroxide and oxygen.	Oxygen	200-206	superoxide dismutase 1	Homo sapiens	109-113
9853916-9	1998	After 30 min of reoxygenation plasma ET-1 increased to 1.8 +/- 0.3 and 1.5 +/- 0.2 ng/L in the room air and O2 groups, respectively (p = 0.0077 in each group versus end hypoxemia; NS between groups).	Oxygen	108-110	endothelin 1	Homo sapiens	37-41
9851743-5	1998	Oxygen tensions of &lt; or =30 torr resulted in TSP-1 transcript induction initially apparent at 1 to 6 hours, with maximal induction (6.5-fold+/-1.2-fold) within 24 to 48 hours in both human and bovine endothelial cells.	Oxygen	0-6	thrombospondin 1	Homo sapiens	48-53
9851743-8	1998	The TSP-1 induction by hypoxia is a graded and reversible physiologic response and can be mimicked by the use of cobalt chloride or the inhibition of nitric oxide production, suggesting both the involvement of a heme-containing oxygen sensor and a role for the endogenous production of nitric oxide in TSP-1 regulation.	Oxygen	228-234	thrombospondin 1	Homo sapiens	4-9
9853916-10	1998	We conclude that hypoxemic pulmonary hypertension and plasma ET-1 normalizes as quickly when reoxygenation is performed with room air as with 100% O2 in this hypoxia model with newborn piglets.	Oxygen	147-149	endothelin 1	Homo sapiens	61-65
9865520-2	1998	Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise.	Oxygen	106-108	formyl peptide receptor 1	Homo sapiens	41-86
9879344-4	1998	A laboratory animal study found that administration of recombinant human erythropoietin (rHuEPO) increased intratumoral median oxygen levels and diminished the proportion of measurements in the very low (&lt; 3 mm Hg) range.	Oxygen	127-133	erythropoietin	Homo sapiens	73-87
9865520-2	1998	Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise.	Oxygen	106-108	formyl peptide receptor 1	Homo sapiens	88-92
9862285-2	1998	Cytochrome P-450-dependent lipid peroxidation was induced by carbon tetrachloride or tert-butylhydroperoxide and was evident by an increase in thiobarbituric acid-reactive substances (TBA-RS) and oxygen consumption.	Oxygen	196-202	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
9822602-1	1998	In response to decreased cellular oxygen concentrations the basic helix-loop-helix (bHLH)/PAS (Per, Arnt, Sim) hypoxia-inducible transcription factor, HIF-1alpha, mediates activation of networks of target genes involved in angiogenesis, erythropoiesis and glycolysis.	Oxygen	34-40	SIM bHLH transcription factor 2	Homo sapiens	106-109
9822602-1	1998	In response to decreased cellular oxygen concentrations the basic helix-loop-helix (bHLH)/PAS (Per, Arnt, Sim) hypoxia-inducible transcription factor, HIF-1alpha, mediates activation of networks of target genes involved in angiogenesis, erythropoiesis and glycolysis.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
9862285-3	1998	In these cytochrome P-450-dependent lipid peroxidation systems, pretreatment of microsome with trisulfide derivatives (cystine trisulfide and thiocyclam) significantly inhibited TBA-RS formation and oxygen consumption compared with disulfide or thiol analogs (cystine, nereistoxin, or cysteine).	Oxygen	199-205	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	9-25
9804599-1	1998	Two near-infrared spectroscopy (NIRS) methods are available for measuring changes (Delta) in total cerebral hemoglobin concentration (CHC): 1) a continuous measurement of the changes in total hemoglobin concentration (Delta[Hb]tot) and 2) the difference between two absolute measurements of CHC, each derived from a small, controlled change in inspired O2 fraction.	Oxygen	353-355	regulator of chromosome condensation 1	Homo sapiens	99-141
9929822-3	1998	Together with activation of the enzyme, changes occur in it which raise the effectiveness of the catalase response under conditions of stimulated production of active forms of oxygen in oxidation stress (increased affinity for the substrate, more expressed changes in activity in response to a change in pH of the medium, limited effect of the inhibitors on the enzyme).	Oxygen	176-182	catalase	Rattus norvegicus	97-105
9844718-1	1998	Human serum albumin (HSA) incorporating synthetic tetraphenylporphinatoiron(II) derivatives (FeP1 or FeP2) can bind and release oxygen reversibly under physiological conditions (in aqueous media, pH 7.4, 37 degrees C).	Oxygen	128-134	albumin	Homo sapiens	21-24
9844718-4	1998	The O2-binding ability of the HSA-FeP can be regulated by changing the molecular structure of the incorporated hemes.	Oxygen	4-6	albumin	Homo sapiens	30-33
19003414-9	1998	Oxygen uptake rate increased during exponential growth phase to a maximum of 40 muM hr-1.	Oxygen	0-6	latexin	Homo sapiens	80-83
9856679-10	1998	After a review of the literature, we hypothesize that she had an inappropriate erythropoietin expression related to an abnormality in the renal oxygen-sensing mechanism governing erythropoietin synthesis.	Oxygen	144-150	erythropoietin	Homo sapiens	79-93
9892094-10	1998	As the atmospheric oxygen concentration was decreased, the PIGF mRNA level in the U-251MG cells was markedly increased.	Oxygen	19-25	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	59-63
9857276-9	1998	CONCLUSIONS: Peak oxygen uptake values can be predicted with reasonable accuracy from the BSU/Bruce Ramp protocol.	Oxygen	18-24	peptidase domain containing associated with muscle regeneration 1	Homo sapiens	100-104
9856679-10	1998	After a review of the literature, we hypothesize that she had an inappropriate erythropoietin expression related to an abnormality in the renal oxygen-sensing mechanism governing erythropoietin synthesis.	Oxygen	144-150	erythropoietin	Homo sapiens	179-193
9865591-8	1998	These findings support the concept that reactive O2 species, primarily H2O2, act as messengers in the O2-dependent control of the hepatic production of Epo.	Oxygen	49-51	erythropoietin	Homo sapiens	152-155
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	173-175	erythropoietin	Homo sapiens	82-96
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	173-175	erythropoietin	Homo sapiens	98-101
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	173-175	vascular endothelial growth factor A	Homo sapiens	107-141
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	173-175	vascular endothelial growth factor A	Homo sapiens	143-147
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	306-308	erythropoietin	Homo sapiens	82-96
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	306-308	erythropoietin	Homo sapiens	98-101
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	306-308	vascular endothelial growth factor A	Homo sapiens	107-141
9804609-1	1998	In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability.	Oxygen	306-308	vascular endothelial growth factor A	Homo sapiens	143-147
9806597-2	1998	The timing of reoxygenation in RIF-1 murine tumors was determined using electron paramagnetic resonance (EPR) oximetry with intratumoral implantation of an oxygen-sensitive paramagnetic material (India ink) to monitor the pO2 in individual murine tumors before, during and after three different irradiation schemes.	Oxygen	16-22	replication timing regulatory factor 1	Mus musculus	31-36
9859864-6	1998	Compared to controls, the amount of eNOS transcripts was found to be elevated at low-oxygen tension, however, cNOS protein was downregulated after 24 h in the hypoxic environment, as shown by immunocytochemistry and Western blot analysis.	Oxygen	85-91	nitric oxide synthase 3	Homo sapiens	36-40
9761763-5	1998	Using cultures of primary human pulmonary fibroblasts and pulmonary vascular smooth muscle cells (VSMC) we show that hypoxia (3% O2) induced transcription and translation of IL-6 (4- to 5-fold) and IL-8 (5- to 6-fold) in both cell types.	Oxygen	129-131	interleukin 6	Homo sapiens	174-178
9788998-1	1998	Cytochrome c oxidase catalyzes the reduction of oxygen to water that is accompanied by pumping of four protons across the mitochondrial or bacterial membrane.	Oxygen	48-54	cytochrome c, somatic	Homo sapiens	0-12
9788999-8	1998	The rate constants for binding of dioxygen exhibited by the quadruple variant are identical to the those observed for wild-type myoglobin (kon, 22.2 x 10(-6) M-1 s-1 vs. 22.3 x 10(-6) M-1 s-1; koff, 24.3 s-1 vs. 24.2 s-1; KO2, 0.91 x 10(-6) M-1 vs. 0.92 x 10(-6) M-1).	Oxygen	34-42	myoglobin	Equus caballus	128-137
9781467-1	1998	OBJECTIVES: To determine oxygen metabolism, permeability, and blood flow in isolated joints in response to interleukin 1beta (IL-1beta) and contribution of innervation.	Oxygen	25-31	interleukin-1 beta	Equus caballus	107-124
9761763-5	1998	Using cultures of primary human pulmonary fibroblasts and pulmonary vascular smooth muscle cells (VSMC) we show that hypoxia (3% O2) induced transcription and translation of IL-6 (4- to 5-fold) and IL-8 (5- to 6-fold) in both cell types.	Oxygen	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
9794818-0	1998	Hypoxia-inducible factor 1: master regulator of O2 homeostasis.	Oxygen	48-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
10417853-6	1998	Recombinant human erythropoietin in patients with chronic renal failure on chronic haemodialysis may influence anaemia not only through its stimulating effect on erythropoiesis, but also by direct oxygen-independent decrease of at least one of the negative regulators of erythropoiesis--the transforming growth factor beta.	Oxygen	197-203	erythropoietin	Homo sapiens	18-32
9893946-8	1998	These results suggest that the expression of mitochondrial encoded subunits (CO-I, CO-II and F0F1-ATPase 6) is up-regulated in response to oxygen and NO reactive species.	Oxygen	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9794818-1	1998	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals.	Oxygen	118-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
9794818-1	1998	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals.	Oxygen	118-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
9794818-2	1998	Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.	Oxygen	47-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-79
9766632-4	1998	In comparison to LPS and tumor necrosis factor (TNF), IL-8 was a much weaker priming agent as measured by either O2- or H2O2 production.	Oxygen	113-115	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9814616-3	1998	We investigated the involvement of endothelin-1 in the blood pressure response to the oxygen carrier diaspirin cross-linked hemoglobin (DCLHb) in stroke patients.	Oxygen	86-92	endothelin 1	Homo sapiens	35-47
9760340-10	1998	In conclusion, after a 28-day altitude training camp, a significant improvement in 5,000-m run performance is, in part, dependent on 1) living at a high enough altitude to achieve a large acute increase in Epo, sufficient to increase the total red cell volume and V(O2)max, and 2) training at a low enough altitude to maintain interval training velocity and O2 flux near sea-level values.	Oxygen	266-268	erythropoietin	Homo sapiens	206-209
9824266-5	1998	Plasma endothelin-1 levels were correlated with pulmonary endothelial nitric oxide synthase levels and alveolar-arterial oxygen gradients.	Oxygen	121-127	endothelin 1	Rattus norvegicus	7-19
9737858-7	1998	The oxygens of the residue to be glycosylated and several flanking residues may also be involved in a set of hydrogen bonds with the GalNAc-T1 and -T3 transferases.	Oxygen	4-11	polypeptide N-acetylgalactosaminyltransferase 1	Homo sapiens	133-150
9863948-2	1998	A new catalase biosensor fabricated using an amperometric gas-diffusion oxygen sensor as electrochemical transducer and the catalase enzyme immobilized in kappa-carrageenan gel and capable of operating in both aqueous and non aqueous solvents was developed and tested for this purpose.	Oxygen	72-78	catalase	Homo sapiens	6-14
9801832-2	1998	The crystal structure reveals that both the amide carbonyl oxygen and the terminal amino nitrogen of Gly-Tyr coordinate to the active site zinc ion of CPA in a bidentate fashion, whereby the zinc-bound water molecule is displaced by the amino group.	Oxygen	59-65	carboxypeptidase A1	Homo sapiens	151-154
9730893-6	1998	As in tumor necrosis factor (TNF)-induced necrosis, Fas treatment led to accumulation of reactive oxygen radicals, and Fas-mediated necrosis was inhibited by the oxygen radical scavenger butylated hydroxyanisole.	Oxygen	98-104	tumor necrosis factor	Mus musculus	29-32
9855704-4	1998	The results demonstrate a keen differential effect of cell density and oxygen concentration on EPO induction in Hep3B compared to HepG2 cells.	Oxygen	71-77	erythropoietin	Homo sapiens	95-98
9777287-1	1998	The proposed oxygen-dependent feed-back loop regulation of EPO production (Fogh 1978, Erslev 1991, LeHir et al 1991, Nielsen 1991) is mainly supported by data from studies in animals and cell cultures.	Oxygen	13-19	erythropoietin	Homo sapiens	59-62
9777287-2	1998	The feed-back loop and its dependence on oxygen was therefore challenged by studies in healthy humans: Exposure of humans to different levels of acute and continued altitude hypobaria provided evidence for an oxygen dependency of the EPO response.	Oxygen	41-47	erythropoietin	Homo sapiens	234-237
9777287-2	1998	The feed-back loop and its dependence on oxygen was therefore challenged by studies in healthy humans: Exposure of humans to different levels of acute and continued altitude hypobaria provided evidence for an oxygen dependency of the EPO response.	Oxygen	209-215	erythropoietin	Homo sapiens	234-237
9777287-4	1998	Exposure to continued altitude hypobaria demonstrated that the decline in human EPO production is initiated before an EPO-induced erythropoiesis is detectable, and that this decline is related to a concomitant decrease in the haemoglobin-oxygen affinity.	Oxygen	238-244	erythropoietin	Homo sapiens	80-83
9777287-5	1998	Contrary to the feed-back loop, this time-relation indicate that the feed-back regulation of EPO production during continued hypobaric hypoxia is exerted primarily through a decrease in the haemoglobin-oxygen affinity, rather than by the effects of an EPO-stimulated erythropoiesis.	Oxygen	202-208	erythropoietin	Homo sapiens	93-96
9777287-8	1998	Contrary to former observations in rodents, the triggering of human EPO production was not related to a hypoxic or normoxic increase of the haemoglobin-oxygen affinity, and normocapnia, without changes in pH or haemoglobin-oxygen affinity, sufficed to suppress the human EPO response to hypoxia.	Oxygen	223-229	erythropoietin	Homo sapiens	68-71
9777287-9	1998	Together with the altitude studies, these results have demonstrated that human EPO production is dependent on, and triggered by, oxygen deprivation, and that changes in the haemoglobin-oxygen affinity play a role mainly in the feed-back regulation rather than in the triggering of human EPO production.	Oxygen	129-135	erythropoietin	Homo sapiens	79-82
9777287-9	1998	Together with the altitude studies, these results have demonstrated that human EPO production is dependent on, and triggered by, oxygen deprivation, and that changes in the haemoglobin-oxygen affinity play a role mainly in the feed-back regulation rather than in the triggering of human EPO production.	Oxygen	185-191	erythropoietin	Homo sapiens	79-82
9777287-9	1998	Together with the altitude studies, these results have demonstrated that human EPO production is dependent on, and triggered by, oxygen deprivation, and that changes in the haemoglobin-oxygen affinity play a role mainly in the feed-back regulation rather than in the triggering of human EPO production.	Oxygen	185-191	erythropoietin	Homo sapiens	287-290
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	26-32	erythropoietin	Homo sapiens	43-57
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	26-32	erythropoietin	Homo sapiens	59-62
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	184-190	erythropoietin	Homo sapiens	43-57
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	184-190	erythropoietin	Homo sapiens	59-62
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	184-190	erythropoietin	Homo sapiens	43-57
9855704-2	1998	So far, investigations of oxygen-regulated erythropoietin (EPO) gene expression in the human hepatoma cell lines Hep3B and HepG2 allowed many important insights into the mechanisms of oxygen-sensing, signalling and regulation of an increasing number of oxygen-responsive genes.	Oxygen	184-190	erythropoietin	Homo sapiens	59-62
9783730-4	1998	Electron spin resonance (ESR) spectrometry studies showed that DT-diaphorase reduced EO9 to a highly oxygen-sensitive metabolite that is probably the hydroquinone.	Oxygen	101-107	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	63-76
9861115-4	1998	The rate of decline in oxygen tension (31 (95% confidence interval (CI) 20.1-42.2) mm Hg min-1) was more than three times that reported in studies in adults.	Oxygen	23-29	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
9777287-16	1998	These results have demonstrated an endogenous, probably hormonal, and oxygen-independent regulation of human EPO production, which is at variance with the oxygen dependent feed-back loop regulation of EPO production.	Oxygen	70-76	erythropoietin	Homo sapiens	109-112
9777287-16	1998	These results have demonstrated an endogenous, probably hormonal, and oxygen-independent regulation of human EPO production, which is at variance with the oxygen dependent feed-back loop regulation of EPO production.	Oxygen	155-161	erythropoietin	Homo sapiens	201-204
9782081-1	1998	The HIF1A gene encodes the HIF-1alpha subunit of hypoxia-inducible factor 1, a transcription factor that is essential for cardiovascular development and systemic O2 homeostasis.	Oxygen	162-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
9766845-2	1998	Despite the primary role of the oxygen-dependent MPO system in the destruction of certain phagocytosed microbes, subjects with total or partial MPO deficiency generally do not have an increased frequency of infections, probably because other MPO-independent mechanism(s) for microbicidal activity compensate for the lack of MPO.	Oxygen	32-38	myeloperoxidase	Homo sapiens	49-52
9731218-1	1998	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is critical for oxygen-dependent expression of many mammalian genes.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
9793069-10	1998	The NO sequestered in Hb is eventually oxidized aerobically to NO3- in the reaction of Fe-NO + O2--&gt;Fe(+) + NO3.	Oxygen	95-97	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
9793069-10	1998	The NO sequestered in Hb is eventually oxidized aerobically to NO3- in the reaction of Fe-NO + O2--&gt;Fe(+) + NO3.	Oxygen	95-97	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
9731218-1	1998	Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is critical for oxygen-dependent expression of many mammalian genes.	Oxygen	141-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
9731202-4	1998	To determine if ARNT plays a role in regulating ALDH3 in response to low oxygen tension, we studied the effects of 1% oxygen and the hypoxia mimic cobalt chloride on constitutive and inducible ALDH3 expression in rat hepatoma cells and rat corneal epithelial cells.	Oxygen	73-79	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	16-20
9746341-0	1998	The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells.	Oxygen	62-68	erythropoietin	Homo sapiens	88-102
9739997-5	1998	However, AK activity in these cultures was markedly suppressed during oxygen-glucose deprivation.	Oxygen	70-76	adenosine kinase	Rattus norvegicus	9-11
9739997-6	1998	Taken together, these data demonstrate a marked down-regulation of AK activity during oxygen-glucose deprivation in this in vitro model, providing an endogenous mechanism contributing to the accumulation of extracellular ADO, which exerts neuroprotective effects by activating the ADO A1 receptor.	Oxygen	86-92	adenosine kinase	Rattus norvegicus	67-69
9712062-11	1998	These results suggest that p38 functions in PMN to signal leukocyte integrin-dependent adhesion and the subsequent massive production of reactive oxygen intermediates.	Oxygen	146-152	mitogen-activated protein kinase 14	Homo sapiens	27-30
9727648-3	1998	This decreases reactive oxygen intermediate formation, tyrosine kinase-induced phosphorylation, and activation of transcription factors that, in turn, decreases the expression of iNOS mRNA.	Oxygen	24-30	nitric oxide synthase 2	Homo sapiens	179-183
9716135-3	1998	A mev-1(kn1) mutant of Caenorhabditis elegans has been found to be hypersensitive to raised oxygen concentrations.	Oxygen	92-98	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	2-7
9699915-12	1998	In addition, by promoting oxygen consumption in the brain, UCP2 could control the production of reactive oxygen species and thereby influence the process of neural degeneration.	Oxygen	26-32	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	59-63
9744563-2	1998	Recently, we found that priming microglia with interferon (IFN)-gamma or tumor necrosis factor (TNF)-alpha resulted in an enhanced production of superoxide anion, a reactive oxygen intermediate that may be pathogenic during brain inflammation.	Oxygen	174-180	interferon gamma	Homo sapiens	47-69
9744563-2	1998	Recently, we found that priming microglia with interferon (IFN)-gamma or tumor necrosis factor (TNF)-alpha resulted in an enhanced production of superoxide anion, a reactive oxygen intermediate that may be pathogenic during brain inflammation.	Oxygen	174-180	tumor necrosis factor	Homo sapiens	73-106
9767182-3	1998	Active oxygen species formed by cytochrome P-450 isoforms can simultaneously act as stimulators of proliferation and inhibitors of intercellular communications.	Oxygen	7-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-48
9696017-4	1998	In addition, ET-1 decreased oxygen uptake and bile secretion in galactosamine-treated livers.	Oxygen	28-34	endothelin 1	Rattus norvegicus	13-17
9679047-2	1998	The purpose of this study was to investigate the role of endothelin 1 in hepatic microcirculation, oxygen transport, and liver injury during endotoxemia.	Oxygen	99-105	endothelin 1	Rattus norvegicus	57-69
9675176-10	1998	The NO3-/NO2- ratio was predicted to vary exponentially with the ratio of O2- to NO release rates from the cells.	Oxygen	10-12	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
9705746-9	1998	Examinations using an oxygen electrode and cytochrome c indicate that molecular oxygen was consumed in the reaction of alpha-tocopherol and Cu(II) and that superoxide was formed.	Oxygen	80-86	cytochrome c, somatic	Homo sapiens	43-55
9694504-5	1998	The effects of TPO, EPO, and G-CSF on Mks, erythrocytes, and granulocytes, respectively, were dependent on the O2 tension.	Oxygen	111-113	thrombopoietin	Homo sapiens	15-18
9694504-5	1998	The effects of TPO, EPO, and G-CSF on Mks, erythrocytes, and granulocytes, respectively, were dependent on the O2 tension.	Oxygen	111-113	erythropoietin	Homo sapiens	20-23
9694504-6	1998	Thrombopoietin-containing cultures under a gas phase of 20%) O2 tension produced 1.4- to 2.2-fold more Mks than those under 5% O2.	Oxygen	61-63	thrombopoietin	Homo sapiens	0-14
9694504-6	1998	Thrombopoietin-containing cultures under a gas phase of 20%) O2 tension produced 1.4- to 2.2-fold more Mks than those under 5% O2.	Oxygen	127-129	thrombopoietin	Homo sapiens	0-14
9694504-7	1998	The increase in Mk size with TPO was also much greater under 20% O2.	Oxygen	65-67	thrombopoietin	Homo sapiens	29-32
9694504-8	1998	Similarly, 2.1- to 2.4-fold more hemoglobin-containing cells were produced in EPO-containing cultures under 20% vs. 5% O2.	Oxygen	119-121	erythropoietin	Homo sapiens	78-81
9694504-9	1998	In contrast, approximately twice as many CD15+ cells were produced in G-CSF-containing cultures under 5% vs. 20%) O2.	Oxygen	114-116	fucosyltransferase 4	Homo sapiens	41-45
9694504-12	1998	Our data also suggest that TPO, EPO, and G-CSF elicit stimulatory cross-lineage effects in the presence of IL-3 and SCF, and that these effects, too, are often dependent on O2 tension.	Oxygen	173-175	thrombopoietin	Homo sapiens	27-30
9694504-12	1998	Our data also suggest that TPO, EPO, and G-CSF elicit stimulatory cross-lineage effects in the presence of IL-3 and SCF, and that these effects, too, are often dependent on O2 tension.	Oxygen	173-175	erythropoietin	Homo sapiens	32-35
9736447-0	1998	Endothelin-1 and NO2/NO3 circulating levels after short-term (1h) oxygen supplementation in patients with chronic respiratory failure during long-term oxygen treatment (LTOT).	Oxygen	151-157	endothelin 1	Homo sapiens	0-12
9736447-1	1998	The effect of acute oxygen administration on endothelin-1 (ET-1) and nitrates (NO.2/NO.3), the latter as stable end products of nitric oxide (NO), were evaluated in arterial and venous blood of chronic respiratory failure (CRF) patients underwent to a continuous long-term oxygen therapy (LTOT).	Oxygen	20-26	endothelin 1	Homo sapiens	45-57
9736447-2	1998	After one hour of oxygen supplementation, ET-1 showed a marked and significant decrease more pronounced in venous blood whereas no statistical change in NO.2/NO.3 concentrations were observed in both arterial and venous blood.	Oxygen	18-24	endothelin 1	Homo sapiens	42-46
9713725-9	1998	Mixed-venous results were used to calculate in vivo the blood gas tension at which hemoglobin was 50% saturated with oxygen (P50).	Oxygen	117-123	nuclear factor kappa B subunit 1	Homo sapiens	125-128
9701579-5	1998	When overexpressed in yeast lacking the superoxide dismutase gene SOD1, both ATX1 and CCH protected the cell from the reactive oxygen toxicity that results from superoxide dismutase deficiency.	Oxygen	127-133	copper chaperone	Arabidopsis thaliana	86-89
9755490-5	1998	Increasing Gd-DOTP and La-DOTP concentration, oxygen affinity for HbA decreases (i.e. P50 increases), this effect being minor for HbF.	Oxygen	46-52	nuclear factor kappa B subunit 1	Homo sapiens	86-89
9697772-4	1998	We find that hypoxia/hypoglycaemia-regulated genes involved in controlling the cell cycle are either HIF-1alpha-dependent (those encoding the proteins p53, p21, Bcl-2) or HIF-1alpha-independent (p27, GADD153), suggesting that there are at least two different adaptive responses to being deprived of oxygen and nutrients.	Oxygen	299-305	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
9660756-2	1998	The hypoxia-inducible factor 1 complex (HIF-1) is involved in the transcriptional activation of several genes, like erythropoietin and vascular endothelial growth factor, that are responsive to the lack of oxygen.	Oxygen	206-212	erythropoietin	Homo sapiens	116-130
9697772-2	1998	Hypoxia-inducible factor (HIF)-1alpha helps to restore oxygen homeostasis by inducing glycolysis, erythropoiesis and angiogenesis.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
9697772-4	1998	We find that hypoxia/hypoglycaemia-regulated genes involved in controlling the cell cycle are either HIF-1alpha-dependent (those encoding the proteins p53, p21, Bcl-2) or HIF-1alpha-independent (p27, GADD153), suggesting that there are at least two different adaptive responses to being deprived of oxygen and nutrients.	Oxygen	299-305	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
9697772-4	1998	We find that hypoxia/hypoglycaemia-regulated genes involved in controlling the cell cycle are either HIF-1alpha-dependent (those encoding the proteins p53, p21, Bcl-2) or HIF-1alpha-independent (p27, GADD153), suggesting that there are at least two different adaptive responses to being deprived of oxygen and nutrients.	Oxygen	299-305	tumor protein p53	Homo sapiens	151-154
9660756-2	1998	The hypoxia-inducible factor 1 complex (HIF-1) is involved in the transcriptional activation of several genes, like erythropoietin and vascular endothelial growth factor, that are responsive to the lack of oxygen.	Oxygen	206-212	vascular endothelial growth factor A	Homo sapiens	135-169
9655768-15	1998	CPT I activity was also significantly correlated with citrate synthase activity (all subjects, r = 0.76) and maximal oxygen consumption expressed in milliliters per kilogram per minute (all subjects, r = 0.69).	Oxygen	117-123	carnitine palmitoyltransferase 1B	Homo sapiens	0-5
9653127-4	1998	We report the identification of an oxygen-dependent degradation (ODD) domain within HIF-1alpha that controls its degradation by the ubiquitin-proteasome pathway.	Oxygen	35-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
9653127-8	1998	Hence, the ODD domain plays a pivotal role for regulating HIF-1 activity and thereby may provide a means of controlling gene expression by changes in oxygen tension.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-63
9715738-6	1998	During the same period, oxygen uptake increased from 1.30 +/- 0.15 to 2.40 +/- 0.23 L min-1, which partially compensated for the decreased anaerobic metabolism.	Oxygen	24-30	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
9662270-0	1998	Elevated plasma endothelin-1 levels in sickle cell anemia: relationships to oxygen saturation and left ventricular hypertrophy.	Oxygen	76-82	endothelin 1	Homo sapiens	16-28
9662270-4	1998	There was a negative correlation between oxygen saturation and Et-1 levels in SCD patients (r = -0.71, P = 0.01).	Oxygen	41-47	endothelin 1	Homo sapiens	63-67
9661561-8	1998	Similarly, HO2 generation by WBCs retrieved from BAL was higher in oxygen-exposed rats (987.74 +/- 128 U.min-1.10(5) WBC) compared with air-exposed animals after an identical injury (348 +/- 9.2 U. min-1.10(5) WBC) (P &lt; 0.05).	Oxygen	67-73	heme oxygenase 2	Rattus norvegicus	11-14
9674473-10	1998	In the ANP group, hemodynamic parameters did not change, but PaO2/FIO2 (fraction of inspired oxygen) and thoracic compliance significantly (p&lt;0.01) increased at 24 h after initiating the ANP infusion, associated with significant (p&lt;0.01) decreases in lung injury score and shunt.	Oxygen	93-99	natriuretic peptide A	Homo sapiens	7-10
9653181-2	1998	We have demonstrated previously that in a murine model of normobaric hypoxia pulmonary fibrin deposition is a result of expression of tissue factor, especially in oxygen-deprived mononuclear phagocytes (MPs).	Oxygen	163-169	coagulation factor III	Mus musculus	134-147
9653181-9	1998	These data delineate a novel biology for hypoxia-induced fibrin deposition, in which oxygen deprivation-induced activation of Egr-1, resulting in expression of tissue factor, has an unexpected and central role.	Oxygen	85-91	coagulation factor III	Mus musculus	160-173
9651185-8	1998	The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA.	Oxygen	196-202	interleukin 6	Homo sapiens	4-8
9651185-8	1998	The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA.	Oxygen	196-202	nuclear factor kappa B subunit 1	Homo sapiens	153-162
9651187-0	1998	Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity.	Oxygen	59-65	superoxide dismutase 2, mitochondrial	Mus musculus	31-36
9651187-3	1998	The mean (+/- SD) survival of Sod2(+/-) mice in 100% O2 was 101.4 +/- 14.8 h (n = 20) versus 103.2 +/- 11.3 h (n = 20) for Sod2(+/+) littermates (P &gt; 0.60).	Oxygen	53-55	superoxide dismutase 2, mitochondrial	Mus musculus	30-34
9651187-5	1998	These results suggest that in mice, only 50% of MnSOD activity may be sufficient for normal resistance to 100% O2 toxicity.	Oxygen	111-113	superoxide dismutase 2, mitochondrial	Mus musculus	48-53
9704782-10	1998	CONCLUSION: In early gestation, the changes in maternal fat mass and basal oxygen consumption are inversely related to the changes in insulin sensitivity.	Oxygen	75-81	insulin	Homo sapiens	134-141
9710349-4	1998	We hypothesized that circulatory insufficiency due to chronic severe hypotension may lead to the stimulation of the Epo production, due to a decreased oxygen supply to peripheral tissues and/or to the stimulation of the renin angiotensin system even in patients with end-stage renal failure.	Oxygen	151-157	erythropoietin	Homo sapiens	116-119
9681420-5	1998	After exposure to 100% O2 for 62 hr, survival was greater in rats injected with the catalase and/or SOD Ad vectors than in control rats.	Oxygen	23-25	catalase	Rattus norvegicus	84-92
9733146-3	1998	Previous studies from our laboratory have demonstrated that tyrosine phosphorylation of p105 and p81 (p105/81), the two major human sperm phosphotyrosine-containing proteins, was under cAMP and oxygen derivatives regulation.	Oxygen	194-200	nuclear factor kappa B subunit 1	Homo sapiens	88-92
9733146-3	1998	Previous studies from our laboratory have demonstrated that tyrosine phosphorylation of p105 and p81 (p105/81), the two major human sperm phosphotyrosine-containing proteins, was under cAMP and oxygen derivatives regulation.	Oxygen	194-200	nuclear factor kappa B subunit 1	Homo sapiens	102-106
18314552-5	1998	Exposure to 70% oxygen between the ages of 4 and 11 days caused afar greater accumulation of carbonyl in mev-1 than in wild type, but not in age-1.	Oxygen	16-22	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	105-110
9720310-6	1998	UV and O2 consumption measurements showed that the reaction of Co with water consumed molecular oxygen and generated Co(II).	Oxygen	7-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
9796506-2	1998	Oxygen-derived free radicals are controlled by various cellular defense mechanisms consisting of enzymatic such as superoxide dismutase, catalase, glutathion peroxidase and nonenzymatic scavenger components.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	115-135
9796506-2	1998	Oxygen-derived free radicals are controlled by various cellular defense mechanisms consisting of enzymatic such as superoxide dismutase, catalase, glutathion peroxidase and nonenzymatic scavenger components.	Oxygen	0-6	catalase	Homo sapiens	137-145
9796506-3	1998	Superoxide dismutase (SOD) is responsible for the dismutation of the superoxide radicals into hydrogen peroxide and molecular oxygen.	Oxygen	126-132	superoxide dismutase 1	Homo sapiens	0-20
9796506-3	1998	Superoxide dismutase (SOD) is responsible for the dismutation of the superoxide radicals into hydrogen peroxide and molecular oxygen.	Oxygen	126-132	superoxide dismutase 1	Homo sapiens	22-25
18314552-7	1998	The age-1 mutant was more resistant to, but mev-1 was more sensitive to, such oxygen enhancements of aging than was wild type.	Oxygen	78-84	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	44-49
9881844-3	1998	Levels of circulating erythropoietin reliably reflect the adequacy of renal oxygen supply under physiological and many pathological conditions.	Oxygen	76-82	erythropoietin	Homo sapiens	22-36
9632793-1	1998	Molecular adaptation to hypoxia depends on the binding of hypoxia-inducible factor 1 (HIF-1) to cognate response elements in oxygen-regulated genes.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-84
9632793-1	1998	Molecular adaptation to hypoxia depends on the binding of hypoxia-inducible factor 1 (HIF-1) to cognate response elements in oxygen-regulated genes.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-91
10198538-4	1998	From ODC parameters in human volunteers, the potential effect of P50 (oxygen pressure at 50% haemoglobin saturation) on oxygen exchangeable fraction (OEF%), for various oxygen partial pressures (oxemia) was evaluated.	Oxygen	120-126	nuclear factor kappa B subunit 1	Homo sapiens	65-68
9661202-1	1998	Polyhemoglobin-superoxide dismutase-catalase is designed to function as an oxygen carrier with antioxidant properties.	Oxygen	75-81	catalase	Rattus norvegicus	36-44
9715819-3	1998	As with other beta-blockers, blockade of cardiac beta-adrenergic receptors (both beta1 and beta2), and hence reduction of cardiac work load and oxygen consumption, plays an important role in the actions of this agent.	Oxygen	144-150	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	81-86
9662516-1	1998	Isoforms Of nadp-malic enzyme NADP-malic enzyme (NADP-ME, EC 1.1.1.40), a key enzyme in C4 photosynthesis, provides CO2 to the bundle-sheath chloroplasts, where it is fixed by ribulose-1,5-bisphosphate carboxylase/oxygenase.	Oxygen	117-120	NADP-dependent malic enzyme	Zea mays	12-29
9662516-1	1998	Isoforms Of nadp-malic enzyme NADP-malic enzyme (NADP-ME, EC 1.1.1.40), a key enzyme in C4 photosynthesis, provides CO2 to the bundle-sheath chloroplasts, where it is fixed by ribulose-1,5-bisphosphate carboxylase/oxygenase.	Oxygen	117-120	NADP-dependent malic enzyme	Zea mays	31-48
9662516-1	1998	Isoforms Of nadp-malic enzyme NADP-malic enzyme (NADP-ME, EC 1.1.1.40), a key enzyme in C4 photosynthesis, provides CO2 to the bundle-sheath chloroplasts, where it is fixed by ribulose-1,5-bisphosphate carboxylase/oxygenase.	Oxygen	117-120	NADP-dependent malic enzyme	Zea mays	50-57
9641269-1	1998	Copper/zinc superoxide dismutase (CuZnSOD) catalyses the conversion of O2.- into H2O2.	Oxygen	71-73	superoxide dismutase 1, soluble	Mus musculus	34-41
9688092-2	1998	We hypothesized that this phenomenon is self-limiting and that polymorphonuclear leukocyte (PMN)-derived reactive oxygen intermediates (ROI) might provide feedback regulation on the IL-1beta surface receptor (IL-1betaR)-G-protein-effector enzyme transducing tripartite complex that ultimately leads to NADPH oxidase activation.	Oxygen	114-120	interleukin 1 beta	Homo sapiens	182-190
9806002-22	1998	Upon stimulation with various agents including cytokines, mitogenes, viruses and reactive oxygen intermediates, I kappa B dissociates from the NF-kappa B-I kappa B complex and translocates to the nucleus, binding with high affinity to specific sites in the promoter regions of target genes and stimulating their transcription.	Oxygen	90-96	nuclear factor kappa B subunit 1	Homo sapiens	143-153
11326879-7	1998	After 60-min oxygenation with 30% oxygen inhalation, the level of ET-1 decreased remarkably, but the levels of NO and CGRP went up notably.	Oxygen	13-19	calcitonin related polypeptide alpha	Homo sapiens	118-122
9618471-3	1998	In the present study, we have used oxygen-17-enriched water and H2O2 to reinvestigate the mechanism of DMPO/.OH formation from the SOD and SOD mutants.	Oxygen	35-41	superoxide dismutase 1	Homo sapiens	131-134
9618471-8	1998	Contrary to earlier reports, the present results indicate that a significant fraction of DMPO/.OH formed during the reaction of SOD and familial ALS SOD mutants with H2O2 is derived from the incorporation of oxygen from water due to oxidation of DMPO to DMPO/.OH presumably via DMPO radical cation.	Oxygen	208-214	superoxide dismutase 1	Homo sapiens	128-131
9609747-8	1998	Exposure to ambient 21% O2 may contribute to increases in AQP-4 and ENaC expression to facilitate water transport across neonatal airway epithelia in the immediate postnatal period.	Oxygen	24-26	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	68-72
9649223-13	1998	Catalase is an important anti-oxidant enzyme and prevents cell damage from highly reactive oxygen-derived free radicals.	Oxygen	91-97	catalase	Homo sapiens	0-8
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	tumor necrosis factor	Homo sapiens	108-117
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	interleukin 1 beta	Homo sapiens	119-128
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	interleukin 6	Homo sapiens	133-137
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	tumor necrosis factor	Homo sapiens	79-88
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	interleukin 1 beta	Homo sapiens	90-99
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	interleukin 6	Homo sapiens	104-108
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
10070569-7	1998	Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6.	Oxygen	77-79	tumor necrosis factor	Homo sapiens	106-115
10070569-7	1998	Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6.	Oxygen	77-79	interleukin 1 beta	Homo sapiens	117-126
10070569-7	1998	Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6.	Oxygen	77-79	interleukin 6	Homo sapiens	131-135
9642094-7	1998	The Gly-1 carbonyl oxygen displays two hydrogen bonds.	Oxygen	19-25	threonine aldolase GLY1	Saccharomyces cerevisiae S288C	4-9
9622066-2	1998	Recent observations suggest that reactive oxygen intermediates play a role in tumor cell growth regulation and expression of the inducible COX, COX-2.	Oxygen	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
9576845-1	1998	In order to elucidate the components of the oxygen sensory complex in HepG2 cells which regulates the production of erythropoietin, we have microinjected recombinant variants of the human small GTP-binding protein hRac1 and measured their effects on the production of reactive oxygen species (ROS) by the dihydrorhodamine-123 technique.	Oxygen	44-50	erythropoietin	Homo sapiens	116-130
9584152-1	1998	Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenic growth factor that promotes compensatory angiogenesis in circumstances of oxygen shortage.	Oxygen	150-156	vascular endothelial growth factor A	Homo sapiens	0-34
9584152-1	1998	Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenic growth factor that promotes compensatory angiogenesis in circumstances of oxygen shortage.	Oxygen	150-156	vascular endothelial growth factor A	Homo sapiens	36-40
9692515-5	1998	There was evidence of an increase in mPAP, MDA, PAF and ET-1 in the plasma, and activity of PLA2, PAF and ET-1 of the lung tissues when the rats inhaled a 10% mixture of oxygen in nitrogen.	Oxygen	170-176	endothelin 1	Rattus norvegicus	56-60
9692515-5	1998	There was evidence of an increase in mPAP, MDA, PAF and ET-1 in the plasma, and activity of PLA2, PAF and ET-1 of the lung tissues when the rats inhaled a 10% mixture of oxygen in nitrogen.	Oxygen	170-176	endothelin 1	Rattus norvegicus	106-110
9593685-2	1998	The reaction of reduced NO synthase (NOS) with molecular oxygen was studied at -30 degreesC.	Oxygen	57-63	nitric oxide synthase 2	Homo sapiens	24-35
9582369-3	1998	In the present report, we investigated the role of reactive oxygen intermediates in TNF-induced signaling.	Oxygen	60-66	tumor necrosis factor	Homo sapiens	84-87
9560296-2	1998	3-Morpholino-sydnonimine (SIN-1), a donor of both NO and O2(-)., leading to the production of ONOO-, dose-dependently inhibited growth of human keratinocytes without loss of viability.	Oxygen	57-59	MAPK associated protein 1	Homo sapiens	26-31
9578592-1	1998	In this paper two hypotheses are tested: (i) the active oxygen species is similar in energetics for all cytochrome P450 (CYP) enzymes and (ii) linear free-energy relationships can be used to evaluate the mechanism of the reaction of these enzymes.	Oxygen	56-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	104-119
9578592-1	1998	In this paper two hypotheses are tested: (i) the active oxygen species is similar in energetics for all cytochrome P450 (CYP) enzymes and (ii) linear free-energy relationships can be used to evaluate the mechanism of the reaction of these enzymes.	Oxygen	56-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-124
9560296-3	1998	This inhibitory effect was lowered when SIN-1 was transformed into a pure NO donor by scavenging O2(-).	Oxygen	97-99	MAPK associated protein 1	Homo sapiens	40-45
9560314-2	1998	We re-evaluated the reported role of reactive oxygen metabolites (ROMs) in signalling upregulation of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by tumour necrosis factor alpha (TNF-alpha) in vitro.	Oxygen	46-52	tumor necrosis factor	Homo sapiens	199-208
9678772-10	1998	The presence of DDC potentiated the inhibition of relaxation (65% inhibition at 1 microM acetylcholine), and co-incubation with exogenous SOD and catalase prevented the inhibition of relaxation, indicating a mediator role of O2-.	Oxygen	225-227	superoxide dismutase 1	Homo sapiens	138-141
9617944-4	1998	The increased oxygen capacity of blood on the addition of PFC emulsion is the main contributor toward this increase.	Oxygen	14-20	complement factor properdin	Homo sapiens	58-61
9617944-6	1998	A near wall excess of PFC droplets, if it occurs, has been shown to have a negligible effect on the tissue oxygen tension during normal rates of tissue oxygen consumption when the intracapillary gradients are small.	Oxygen	152-158	complement factor properdin	Homo sapiens	22-25
9678772-10	1998	The presence of DDC potentiated the inhibition of relaxation (65% inhibition at 1 microM acetylcholine), and co-incubation with exogenous SOD and catalase prevented the inhibition of relaxation, indicating a mediator role of O2-.	Oxygen	225-227	catalase	Homo sapiens	146-154
9626590-7	1998	Because CYP3A4 is present in high amounts in human liver microsomes and is active in catalyzing the formation of reactive oxygen species, this CYP may make an important contribution in the overall ability of human liver microsomes to generate active oxygen species.	Oxygen	122-128	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-14
9558386-3	1998	Compared with control cells cultured under standard conditions (20% O2), HTR-8/SVneo cells and HUVEC cultured in 1% O2 expressed more uPAR, as determined by flow cytometric and [125I]-prourokinase ligand binding analyses.	Oxygen	116-118	plasminogen activator, urokinase	Homo sapiens	134-138
9521897-9	1998	These findings also provide a cellular basis for clinical observations that vascular regression in premature neonates subjected to oxygen therapy [i.e. in retinopathy of prematurity] drops precipitously upon maturation of retina vessels and a mechanistic explanation to our previous findings that VEGF can rescue immature vessels from hyperoxia-induced regression.	Oxygen	131-137	vascular endothelial growth factor A	Homo sapiens	297-301
9654063-4	1998	A reaction pathway like that of cytochrome P-450 implies oxygen transfer to the substrate from the as yet uncharacterized iron-oxo species formed in the reaction of the heine cofactor with H2O2.	Oxygen	57-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-48
9654063-6	1998	The results of the present study exclude Fenton-type chemistry and prove that the minicatalyst is able to catalyze the oxygen incorporation by both peroxidase and cytochrome P-450 types of reaction pathways, while exchange occurs between the high-valency iron-oxo species and H2O.	Oxygen	119-125	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	163-179
9654078-0	1998	Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site.	Oxygen	0-6	erythropoietin	Homo sapiens	17-31
9654078-0	1998	Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-113
9654078-1	1998	The hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in the expression of oxygen-regulated genes such as that for erythropoietin.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
9654078-1	1998	The hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in the expression of oxygen-regulated genes such as that for erythropoietin.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
9654078-1	1998	The hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in the expression of oxygen-regulated genes such as that for erythropoietin.	Oxygen	100-106	erythropoietin	Homo sapiens	140-154
9654078-2	1998	Following exposure to low oxygen partial pressure (hypoxia), HIF-1 binds to an hypoxia-response element located 3" to the erythropoietin gene and confers activation of erythropoietin expression.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
9654078-2	1998	Following exposure to low oxygen partial pressure (hypoxia), HIF-1 binds to an hypoxia-response element located 3" to the erythropoietin gene and confers activation of erythropoietin expression.	Oxygen	26-32	erythropoietin	Homo sapiens	122-136
9654078-2	1998	Following exposure to low oxygen partial pressure (hypoxia), HIF-1 binds to an hypoxia-response element located 3" to the erythropoietin gene and confers activation of erythropoietin expression.	Oxygen	26-32	erythropoietin	Homo sapiens	168-182
9578472-4	1998	In the present study, attention has been focused on the relative reactivities of HNO2, peroxynitrite, and NO in the presence of dioxygen, towards the arginine and tyrosine residues of the peptide angiotensin II.	Oxygen	128-136	angiotensinogen	Homo sapiens	196-210
9574558-10	1998	These findings suggest that TNF-alpha down-regulates CXCR2 expression on PMNs and modulates IL-8-induced biologic responses, leading to the intravascular retention of PMNs with an enhanced production of reactive oxygen metabolites.	Oxygen	212-218	tumor necrosis factor	Homo sapiens	28-37
9574558-10	1998	These findings suggest that TNF-alpha down-regulates CXCR2 expression on PMNs and modulates IL-8-induced biologic responses, leading to the intravascular retention of PMNs with an enhanced production of reactive oxygen metabolites.	Oxygen	212-218	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9575883-7	1998	IGFBP-2, -4, and -5 immunolocalized to airway epithelial cells in normal lung and to perivascular exudates after 6 days in 85% O2.	Oxygen	127-129	insulin-like growth factor binding protein 2	Rattus norvegicus	0-19
9556634-5	1998	In fact, an increase of KCN-dependent O2 consumption accompanied the expression of Bax.	Oxygen	38-40	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
9556634-9	1998	It is proposed that trace amounts of Bax increase oxygen consumption, triggering generation of superoxide, which affects DNA, leading to bacterial death.	Oxygen	50-56	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
9587414-12	1998	Stimulation of the cells with O2- also induced a minimal degree of NF-kappa B activation.	Oxygen	30-32	nuclear factor kappa B subunit 1	Homo sapiens	67-77
9508090-0	1998	Increased expression of NADH-ubiquinone oxidoreductase chain 2 (ND2) in preimplantation rabbit embryos cultured with 20% oxygen concentration.	Oxygen	121-127	NADH dehydrogenase subunit 2	Oryctolagus cuniculus	24-62
9510527-5	1998	In addition to erythropoietin, HIF-1-responsive genes include examples with functions in cellular energy metabolism, iron metabolism, catecholamine metabolism, vasomotor control and angiogenesis, suggesting an important role in the coordination of oxygen supply and cellular metabolism.	Oxygen	248-254	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-36
9510530-0	1998	Erythropoietin: a model system for studying oxygen-dependent gene regulation.	Oxygen	44-50	erythropoietin	Homo sapiens	0-14
9669840-7	1998	However, ex vivo expansion of the sorted subsets with interleukin 3, stem cell factor and FLT3 ligand for 2 weeks resulted in a significant production of O2- and H2O2/HOCl by CD34+/CD117low cell fraction, compared to the same sorted but not expanded counterparts.	Oxygen	154-156	fms related receptor tyrosine kinase 3	Homo sapiens	90-94
9669840-7	1998	However, ex vivo expansion of the sorted subsets with interleukin 3, stem cell factor and FLT3 ligand for 2 weeks resulted in a significant production of O2- and H2O2/HOCl by CD34+/CD117low cell fraction, compared to the same sorted but not expanded counterparts.	Oxygen	154-156	CD34 molecule	Homo sapiens	175-179
9508090-0	1998	Increased expression of NADH-ubiquinone oxidoreductase chain 2 (ND2) in preimplantation rabbit embryos cultured with 20% oxygen concentration.	Oxygen	121-127	NADH dehydrogenase subunit 2	Oryctolagus cuniculus	64-67
9508090-8	1998	mRNA expression of ND2 was increased in blastocysts cultured with the higher oxygen concentration.	Oxygen	77-83	NADH dehydrogenase subunit 2	Equus caballus	19-22
9521739-9	1998	Inactivation of iNOS by L-N6-(1-iminoethyl)lysine was NADPH- and dioxygen-dependent, but low incorporation of radiolabel with DL--4, 5-3H]-N6-(1-iminoethyl)lysine indicates that the mechanism of enzyme inactivation is not covalent modification of the protein.	Oxygen	65-73	nitric oxide synthase 2	Homo sapiens	16-20
9502265-4	1998	The present study using the cat carotid body demonstrates profound changes in the levels of immunoreactivity of the catecholamine-synthesizing enzyme, tyrosine hydroxylase, and the neuropeptide, substance P, in response to a two-week exposure to hypoxia (10% O2 in 90% N2).	Oxygen	259-261	tyrosine hydroxylase	Homo sapiens	151-171
9502265-4	1998	The present study using the cat carotid body demonstrates profound changes in the levels of immunoreactivity of the catecholamine-synthesizing enzyme, tyrosine hydroxylase, and the neuropeptide, substance P, in response to a two-week exposure to hypoxia (10% O2 in 90% N2).	Oxygen	259-261	tachykinin precursor 1	Homo sapiens	195-206
11324535-3	1998	AT II secretion decreased significantly when PASMCs were incubated under 2.5% O2 hypoxic condition for 3 to 48 h (P &lt; 0.01 vs control), but decreased further under anoxic condition (P &lt; 0.01 vs control and 2.5% O2 group).	Oxygen	78-80	angiotensinogen	Homo sapiens	0-5
11324535-3	1998	AT II secretion decreased significantly when PASMCs were incubated under 2.5% O2 hypoxic condition for 3 to 48 h (P &lt; 0.01 vs control), but decreased further under anoxic condition (P &lt; 0.01 vs control and 2.5% O2 group).	Oxygen	217-219	angiotensinogen	Homo sapiens	0-5
9516486-1	1998	Copper-zinc superoxide dismutase (CuZn-SOD) is believed to play a major role in the first line of antioxidant defense by catalyzing the dismutation of superoxide anion radicals to form hydrogen peroxide and molecular oxygen.	Oxygen	217-223	superoxide dismutase 1, soluble	Mus musculus	34-42
9507022-1	1998	Myeloperoxidase (MPO) is a neutrophil lysosomal hemeprotein essential for optimal oxygen-dependent microbicidal activity.	Oxygen	82-88	myeloperoxidase	Homo sapiens	0-15
9507022-1	1998	Myeloperoxidase (MPO) is a neutrophil lysosomal hemeprotein essential for optimal oxygen-dependent microbicidal activity.	Oxygen	82-88	myeloperoxidase	Homo sapiens	17-20
9566715-3	1998	In this study we used Rat1 fibroblasts containing a conditionally active form of oncogenic c-Myc (MycER) to investigate single cell line TNF-induced free oxygen radical formation during the non-cytotoxic TNF-response (inactive c-Myc) and cytotoxic response (active c-Myc).	Oxygen	154-160	tumor necrosis factor	Rattus norvegicus	137-140
9501198-6	1998	Furthermore, restoration of peroxisomal functions by targeting catalase-SKL protein (a catalase fused to the PTS1 sequence) to peroxisomes indicates that loss of multiple functions may be due to their inactivation by H2O2 or other oxygen species in these catalase-negative peroxisomes.	Oxygen	231-237	catalase	Homo sapiens	63-71
9501198-6	1998	Furthermore, restoration of peroxisomal functions by targeting catalase-SKL protein (a catalase fused to the PTS1 sequence) to peroxisomes indicates that loss of multiple functions may be due to their inactivation by H2O2 or other oxygen species in these catalase-negative peroxisomes.	Oxygen	231-237	catalase	Homo sapiens	87-95
9501198-6	1998	Furthermore, restoration of peroxisomal functions by targeting catalase-SKL protein (a catalase fused to the PTS1 sequence) to peroxisomes indicates that loss of multiple functions may be due to their inactivation by H2O2 or other oxygen species in these catalase-negative peroxisomes.	Oxygen	231-237	catalase	Homo sapiens	87-95
9559540-6	1998	The SCS7 gene encodes a protein that contains both a cytochrome b5-like domain and a domain that resembles the family of cytochrome b5-dependent enzymes that use iron and oxygen to catalyse desaturation or hydroxylation of fatty acids and sterols.	Oxygen	171-177	fatty acid alpha-hydroxylase	Saccharomyces cerevisiae S288C	4-8
9502405-5	1998	Intraperitoneal administration of MR1, either before or after oxygen exposure, was remarkably effective in reducing and in many cases preventing lung injury.	Oxygen	62-68	major histocompatibility complex, class I-related	Homo sapiens	34-37
9871590-2	1998	It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively.	Oxygen	139-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-199
9871590-2	1998	It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively.	Oxygen	175-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-199
9578385-16	1998	The oxygen sensitivity of tyrosine hydroxylase (TH) activity, may be one possible mechanism.	Oxygen	4-10	tyrosine hydroxylase	Homo sapiens	26-46
9578385-16	1998	The oxygen sensitivity of tyrosine hydroxylase (TH) activity, may be one possible mechanism.	Oxygen	4-10	tyrosine hydroxylase	Homo sapiens	48-50
9502405-7	1998	Immunohistochemical staining for Cox-2 revealed that MR1 greatly reduces the oxygen-induced induction of Cox-2.	Oxygen	77-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-38
9502405-7	1998	Immunohistochemical staining for Cox-2 revealed that MR1 greatly reduces the oxygen-induced induction of Cox-2.	Oxygen	77-83	major histocompatibility complex, class I-related	Homo sapiens	53-56
9502405-7	1998	Immunohistochemical staining for Cox-2 revealed that MR1 greatly reduces the oxygen-induced induction of Cox-2.	Oxygen	77-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-110
9502405-8	1998	The remarkable effectiveness of MR1 in blunting hyperoxic lung injury in this preclinical model may be relevant to the hundreds of thousands of patients who require treatment with high oxygen and who are at risk for developing severe pulmonary inflammation and consequent fibrosis.	Oxygen	185-191	major histocompatibility complex, class I-related	Homo sapiens	32-35
9502405-9	1998	Strategies to disrupt CD40-CD40L interactions may offer a new mode of intervention for oxygen-induced acute respiratory distress syndrome and other inflammatory lung disorders.	Oxygen	87-93	CD40 ligand	Homo sapiens	27-32
9541163-8	1998	The induction of apoptosis by the non-metabolisable glucose suggests that formation of oxygen derived radicals by autoxidative processes is involved and may lead to an activation of transcription factors such as nuclear transcription factor-kappaB (NF-kappaB) transferring the activation signal into the nucleus and leading to changes in gene expression necessary for induction of apoptosis.	Oxygen	87-93	nuclear factor kappa B subunit 1	Homo sapiens	212-247
9611637-1	1998	We sought to determine if predicted post-operative maximal oxygen uptake (VO2max/kg-PPO) was associated to the occurrence of respiratory or cardiac failure within the 60 days following lung surgery and to evaluate its validity as operability criterion.	Oxygen	59-65	protoporphyrinogen oxidase	Homo sapiens	84-87
9524553-8	1998	This reaction is not inhibited by O2, indicating that reoxidation of the Co(II) intermediate by O2 is not rapid enough to compete with ligand dissociation.	Oxygen	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
9541163-8	1998	The induction of apoptosis by the non-metabolisable glucose suggests that formation of oxygen derived radicals by autoxidative processes is involved and may lead to an activation of transcription factors such as nuclear transcription factor-kappaB (NF-kappaB) transferring the activation signal into the nucleus and leading to changes in gene expression necessary for induction of apoptosis.	Oxygen	87-93	nuclear factor kappa B subunit 1	Homo sapiens	249-258
9568451-10	1998	The improvement in oxygen consumption after 16 weeks training was higher than after 6 weeks (+2.6 +/- 3.0 vs +0.3 +/- 3.1 ml.kg.min-1, P &lt; 0.05).	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	128-133
9468538-1	1998	Myeloperoxidase (MPO), stored in azurophil granules of neutrophils, is critical for an optimal oxygen-dependent microbicidal activity of these cells.	Oxygen	95-101	myeloperoxidase	Homo sapiens	0-15
9667422-14	1998	These data suggest that iC3b deposition on the vascular endothelium may be regulated by intracellular oxygen-derived free radical-induced activation of NF-kappaB, new protein synthesis and activation of the classical complement pathway during ischemia/reperfusion.	Oxygen	102-108	nuclear factor kappa B subunit 1	Homo sapiens	152-161
9617859-1	1998	Interleukin-8 (IL-8) is a peptide which induces not only chemotaxis of neutrophils but also the release of reactive oxygen metabolites from the neutrophils.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9617859-1	1998	Interleukin-8 (IL-8) is a peptide which induces not only chemotaxis of neutrophils but also the release of reactive oxygen metabolites from the neutrophils.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9549667-4	1998	Indeed, within 15 minutes after initiation of an AVP infusion, the patient exhibited hypotension with a systolic blood pressure of 80 mmHg, a relative bradycardia to 76 beats per minute, and a desaturation of blood oxygen to 84%.	Oxygen	215-221	arginine vasopressin	Homo sapiens	49-52
9592707-5	1998	Control of coronary vasomotor tone and proliferation processes within the vessel wall are both determined by the redox equilibrium of nitric oxide (NO) and superoxide radicals (O2-), induced by angiotensin II.	Oxygen	177-179	angiotensinogen	Homo sapiens	194-208
9654715-15	1998	CONCLUSIONS: If we accept that the EPO-level in fetal blood rises with relevant oxygen deficiency, then females seems to be better protected against damage from distress.	Oxygen	80-86	erythropoietin	Homo sapiens	35-38
9468538-1	1998	Myeloperoxidase (MPO), stored in azurophil granules of neutrophils, is critical for an optimal oxygen-dependent microbicidal activity of these cells.	Oxygen	95-101	myeloperoxidase	Homo sapiens	17-20
9461572-11	1998	These results indicate that the peroxide-generated radicals in PGHS-2 and MnPGHS-1 can each serve as immediate oxidants of AA to form the same carbon-centered fatty acid radical that subsequently reacts with oxygen to form a hydroperoxide.	Oxygen	208-214	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-69
9454748-1	1998	Embryonic stem cells and embryonal carcinoma P19 cells produce erythropoietin (Epo) in an oxygen-independent manner, although lactate dehydrogenase A (LDHA) is hypoxia-inducible.	Oxygen	90-96	erythropoietin	Homo sapiens	63-77
9454748-1	1998	Embryonic stem cells and embryonal carcinoma P19 cells produce erythropoietin (Epo) in an oxygen-independent manner, although lactate dehydrogenase A (LDHA) is hypoxia-inducible.	Oxygen	90-96	erythropoietin	Homo sapiens	79-82
9476910-0	1998	Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5" distal enhancers: role of reactive oxygen intermediates and AP-1.	Oxygen	119-125	heme oxygenase 1	Mus musculus	34-38
9490829-22	1998	Thus, removal of oxygen, uncoupling mitochondrial oxidative phosphorylation or inhibition of respiration, all lead to mitochondrial depolarization, an increased Ca2+ influx through (voltage-gated) channels, even at hyperpolarized membrane potentials, raising [Ca2+]i which in turn drives an increased K+ conductance that modulates membrane excitability.	Oxygen	17-23	carbonic anhydrase 2	Rattus norvegicus	161-164
9490829-22	1998	Thus, removal of oxygen, uncoupling mitochondrial oxidative phosphorylation or inhibition of respiration, all lead to mitochondrial depolarization, an increased Ca2+ influx through (voltage-gated) channels, even at hyperpolarized membrane potentials, raising [Ca2+]i which in turn drives an increased K+ conductance that modulates membrane excitability.	Oxygen	17-23	carbonic anhydrase 2	Rattus norvegicus	260-263
9462547-2	1998	Circulating erythropoietin values are regulated by renal oxygen supply, which is determined by hemoglobin concentration, hemoglobin oxygen saturation, and renal blood flow.	Oxygen	57-63	erythropoietin	Homo sapiens	12-26
9462547-2	1998	Circulating erythropoietin values are regulated by renal oxygen supply, which is determined by hemoglobin concentration, hemoglobin oxygen saturation, and renal blood flow.	Oxygen	132-138	erythropoietin	Homo sapiens	12-26
9535583-8	1998	When averaged across conditions, oxygen consumption (VO2) increased significantly (P &lt; 0.01) from pre- to post-test [from 38.5 to 40.5 ml x kg(-1) x min(-1) at 200 m x min(-1), and from 53.1 to 54.5 ml x kg(-1) x min(-1) at 268 m x min(-1), respectively].	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	152-158
9526115-3	1998	DMOBQ, taken even at submicromolar concentrations, effectively catalyzed AscH- oxidation that manifested itself by intensive oxygen consumption and an increase in the steady-state concentration of the ascorbyl radical (Asc.-).	Oxygen	125-131	PYD and CARD domain containing	Homo sapiens	73-76
9526115-4	1998	The rate of oxygen consumption, ROX, was kept almost constant for a long time.	Oxygen	12-18	MAX network transcriptional repressor	Homo sapiens	32-35
9635150-1	1998	The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstriction.	Oxygen	87-93	angiotensinogen	Rattus norvegicus	45-59
9635150-1	1998	The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstriction.	Oxygen	87-93	angiotensinogen	Rattus norvegicus	61-64
9523087-4	1998	The ability of lens catalase to convert H2O2 into O2 was measured directly, using an oxygen electrode and meter.	Oxygen	42-44	catalase	Homo sapiens	20-28
9523087-4	1998	The ability of lens catalase to convert H2O2 into O2 was measured directly, using an oxygen electrode and meter.	Oxygen	85-91	catalase	Homo sapiens	20-28
9523087-5	1998	This method is very specific, as catalase is the only enzyme that converts H2O2 to O2.	Oxygen	77-79	catalase	Homo sapiens	33-41
9523087-6	1998	RESULTS: Catalase in the lenses of humans, rabbits, and squirrels catalyzed the production of O2 from H2O2 very efficiently.	Oxygen	94-96	catalase	Homo sapiens	9-17
9521050-4	1998	We show that cross-linking of P-selectin glycoprotein ligand-1 (PSGL-1) on mouse neutrophils with an antibody-like recombinant form of P-selectin or with monoclonal antibodies stimulated the production of reactive oxygen intermediates and enhanced neutrophil attachment to intercellular adhesion molecule 1 (ICAM-1)-expressing CHO cells.	Oxygen	214-220	selectin, platelet	Mus musculus	30-40
9535583-8	1998	When averaged across conditions, oxygen consumption (VO2) increased significantly (P &lt; 0.01) from pre- to post-test [from 38.5 to 40.5 ml x kg(-1) x min(-1) at 200 m x min(-1), and from 53.1 to 54.5 ml x kg(-1) x min(-1) at 268 m x min(-1), respectively].	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	171-177
9535583-8	1998	When averaged across conditions, oxygen consumption (VO2) increased significantly (P &lt; 0.01) from pre- to post-test [from 38.5 to 40.5 ml x kg(-1) x min(-1) at 200 m x min(-1), and from 53.1 to 54.5 ml x kg(-1) x min(-1) at 268 m x min(-1), respectively].	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	171-177
9645391-1	1998	The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells.	Oxygen	77-83	tumor necrosis factor	Homo sapiens	129-150
9645391-1	1998	The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells.	Oxygen	77-83	tumor necrosis factor	Homo sapiens	152-155
9535583-8	1998	When averaged across conditions, oxygen consumption (VO2) increased significantly (P &lt; 0.01) from pre- to post-test [from 38.5 to 40.5 ml x kg(-1) x min(-1) at 200 m x min(-1), and from 53.1 to 54.5 ml x kg(-1) x min(-1) at 268 m x min(-1), respectively].	Oxygen	33-39	CD59 molecule (CD59 blood group)	Homo sapiens	171-177
9645391-1	1998	The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells.	Oxygen	77-83	vascular cell adhesion molecule 1	Homo sapiens	208-248
9749707-3	1998	Therefore we investigated the expression and localization of iNOS after oxygen and glucose deprivation in rat forebrain slices.	Oxygen	72-78	nitric oxide synthase 2	Rattus norvegicus	61-65
9645391-9	1998	On this basis we assume that the oxygen dependent step in the intracellular signalling cascade underlying the TNFalpha stimulated transcriptional activation of VCAM-1 resides in the activity of a cytochrome P450 dependent monooxygenase.	Oxygen	33-39	tumor necrosis factor	Homo sapiens	110-118
9645391-9	1998	On this basis we assume that the oxygen dependent step in the intracellular signalling cascade underlying the TNFalpha stimulated transcriptional activation of VCAM-1 resides in the activity of a cytochrome P450 dependent monooxygenase.	Oxygen	33-39	vascular cell adhesion molecule 1	Homo sapiens	160-166
9749707-8	1998	Furthermore, oxygen and glucose deprivation caused the expression of the gene encoding iNOS in rat forebrain slices, as assessed by the detection of iNOS message and protein in these samples.	Oxygen	13-19	nitric oxide synthase 2	Rattus norvegicus	87-91
9749707-8	1998	Furthermore, oxygen and glucose deprivation caused the expression of the gene encoding iNOS in rat forebrain slices, as assessed by the detection of iNOS message and protein in these samples.	Oxygen	13-19	nitric oxide synthase 2	Rattus norvegicus	149-153
9749707-11	1998	These results demonstrate for the first time that iNOS is expressed in neurones after oxygen and glucose deprivation, and that this expression occurs in short periods of time.	Oxygen	86-92	nitric oxide synthase 2	Rattus norvegicus	50-54
9449700-2	1998	In this study, we show that oxygen regulates nitric oxide (NO) levels through effects on NO synthase (NOS) enzyme kinetics.	Oxygen	28-34	nitric oxide synthase 2	Homo sapiens	89-100
9449700-9	1998	Purified NOS type II enzyme activity in vitro was similarly dependent on molecular oxygen levels (KmO2 135 microM), revealing a means by which oxygen concentration affects NO levels in vivo.	Oxygen	83-89	nitric oxide synthase 2	Homo sapiens	9-20
9449700-9	1998	Purified NOS type II enzyme activity in vitro was similarly dependent on molecular oxygen levels (KmO2 135 microM), revealing a means by which oxygen concentration affects NO levels in vivo.	Oxygen	143-149	nitric oxide synthase 2	Homo sapiens	9-20
9468285-1	1998	Myeloperoxidase (MPO) is an essential component of the oxygen-dependent microbicidal system of neutrophils and monocytes.	Oxygen	55-61	myeloperoxidase	Homo sapiens	0-15
9468285-1	1998	Myeloperoxidase (MPO) is an essential component of the oxygen-dependent microbicidal system of neutrophils and monocytes.	Oxygen	55-61	myeloperoxidase	Homo sapiens	17-20
9454799-11	1998	We conclude that a potential oxygen-sensing mechanism of epithelial cells involves the cooperation of heme-containing proteins such as guanylate cyclase and that biochemical cross-talk between cAMP- and cGMP-stimulated pathways may be important in such responses.	Oxygen	29-35	cathelicidin antimicrobial peptide	Homo sapiens	193-198
9802960-6	1998	In the 85% O2-exposed cells, hyperoxia increased lipid peroxidation (thiobarbituric acid reactive substances, TBARS production) 2-fold and iNOS mRNA production 5.4-fold.	Oxygen	11-13	nitric oxide synthase 2	Rattus norvegicus	139-143
9475529-7	1998	CONCLUSIONS: Raising infant piglets in an environment of 10% oxygen for 4 weeks results in significant pulmonary arterial hypertension accompanied by increased expression of nitric oxide synthase within the lung endothelium.	Oxygen	61-67	nitric oxide synthase 2	Sus scrofa	174-195
9551742-2	1998	It is based on the assumption that neutrophils entering the lumen of the infected airways undergo activation and release toxic oxygen metabolites and myeloperoxidase (MPO), an enzyme which transforms hydrogen peroxide (H2O2) into highly toxic oxygen metabolites.	Oxygen	243-249	myeloperoxidase	Homo sapiens	150-165
9551742-2	1998	It is based on the assumption that neutrophils entering the lumen of the infected airways undergo activation and release toxic oxygen metabolites and myeloperoxidase (MPO), an enzyme which transforms hydrogen peroxide (H2O2) into highly toxic oxygen metabolites.	Oxygen	243-249	myeloperoxidase	Homo sapiens	167-170
9529979-6	1998	There was a significant decrease in the rate of DNA synthesis as early as 24 h. The mRNA expression of IL-1 beta and TNFa seemed less influenced by hyperoxia, while IL-8 and TGF beta showed marked increase in mRNA levels at 6 h of 100% oxygen exposure.	Oxygen	236-242	interleukin 1 beta	Homo sapiens	103-112
9512648-5	1998	The in vitro exposure of the aortic CEH to active oxygen (AO) generators revealed the PKC-mediated activation of CEH, which was inhibited by superoxide dismutase and catalase.	Oxygen	50-56	catalase	Rattus norvegicus	166-174
9446584-0	1998	Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme.	Oxygen	0-6	seed linoleate 13S-lipoxygenase-1	Glycine max	60-74
9446584-1	1998	The effect of oxygen concentration on the regiospecificity of the soybean lipoxygenase-1 dioxygenation reaction was studied.	Oxygen	14-20	seed linoleate 13S-lipoxygenase-1	Glycine max	74-88
9442050-0	1998	The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase.	Oxygen	82-88	nitric oxide synthase 2	Homo sapiens	101-122
9436976-0	1998	Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.	Oxygen	38-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-88
9914810-5	1998	These observations suggest that the levels of erythropoietin depends not only by the tissue oxygen availability but by others factors related to the marrow cellularity.	Oxygen	92-98	erythropoietin	Homo sapiens	46-60
9436976-7	1998	These results demonstrate that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis.	Oxygen	94-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
9762350-3	1998	DT-Diaphorase does not cause the production of an aerobic/hypoxic differential toxicity by mitomycin C, but rather activates this agent through an oxygen insensitive pathway.	Oxygen	147-153	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
9581011-6	1998	Furthermore, the copper-zinc-containing enzyme SOD (superoxide dismutase) can act as a scavenger of toxic oxygen in the tissues.	Oxygen	106-112	superoxide dismutase 1	Homo sapiens	47-50
9889895-1	1998	Myoglobin (Mb), the muscular oxygen reservoir, was shown to possess peroxidative reactivity in presence of H2O2 leading to oxidation of isolated cellular proteins like myosin.	Oxygen	29-35	myoglobin	Gallus gallus	0-9
9889895-1	1998	Myoglobin (Mb), the muscular oxygen reservoir, was shown to possess peroxidative reactivity in presence of H2O2 leading to oxidation of isolated cellular proteins like myosin.	Oxygen	29-35	myoglobin	Gallus gallus	11-13
9581011-6	1998	Furthermore, the copper-zinc-containing enzyme SOD (superoxide dismutase) can act as a scavenger of toxic oxygen in the tissues.	Oxygen	106-112	superoxide dismutase 1	Homo sapiens	52-72
9581011-9	1998	Another drug, penicillamine, that protects cellular membranes against toxic oxygen in vitro, is presumed to act as an antirheumatic via the SOD mimetic activity of its copper complex.	Oxygen	76-82	superoxide dismutase 1	Homo sapiens	140-143
9923724-10	1998	Kinetic analysis indicated that the chronic ethanol-induced decrease in the glycerol 3-phosphate dehydrogenase reaction was due to a decreased rate of NADH reoxidation in the liver, likely owing to a decrease in oxygen supply or utilization in the ethanol-treated rats.	Oxygen	212-218	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	76-110
9750811-2	1998	It followed a lung inflation with a O2/N2O mixture for about 30 seconds at a pressure of at least 40 cmH2O in order to obtain apnoea for CT scan and to recruit atelectatic territories.	Oxygen	36-38	troponin T2, cardiac type	Homo sapiens	101-105
9458943-7	1998	The incidence of shivering was not influenced by TRH, but treated lambs maintained a higher rate of O2 consumption and ventilation compared with controls after colonic temperature had been restored to 38.56 degrees C. TRH appeared to promote fat oxidation as O2 consumption remained unchanged and CO2 production declined by a greater rate in treated lambs, resulting in a lower respiratory quotient compared to controls.	Oxygen	100-102	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	218-221
9458943-7	1998	The incidence of shivering was not influenced by TRH, but treated lambs maintained a higher rate of O2 consumption and ventilation compared with controls after colonic temperature had been restored to 38.56 degrees C. TRH appeared to promote fat oxidation as O2 consumption remained unchanged and CO2 production declined by a greater rate in treated lambs, resulting in a lower respiratory quotient compared to controls.	Oxygen	259-261	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	218-221
9646871-1	1998	Cytochrome c oxidase, the terminal enzyme of the respiratory chains of mitochondria and aerobic bacteria, catalyzes electron transfer from cytochrome c to molecular oxygen, reducing the latter to water.	Oxygen	165-171	cytochrome c, somatic	Homo sapiens	0-12
9646871-1	1998	Cytochrome c oxidase, the terminal enzyme of the respiratory chains of mitochondria and aerobic bacteria, catalyzes electron transfer from cytochrome c to molecular oxygen, reducing the latter to water.	Oxygen	165-171	cytochrome c, somatic	Homo sapiens	139-151
9791941-13	1998	This indicates that in the bacterium/neutrophilic granulocyte system oxygen metabolites are generated that are capable of reacting with MPO.	Oxygen	69-75	myeloperoxidase	Homo sapiens	136-139
9678873-1	1998	Insulin-immobilized polyurethanes (PU) were prepared by the graft polymerization of acrylic acid on oxygen plasma-treated PU, followed by a coupling reaction with polyethylene oxide (PEO) and subsequently with insulin.	Oxygen	100-106	insulin	Homo sapiens	0-7
10452833-7	1998	At 21%p O(2), the presence of asc-2-P and dex induced significantly greater (P&lt; 0.01, ANOVA) cell proliferation than with either additives alone.	Oxygen	8-12	pyrin domain containing 1	Homo sapiens	30-35
9423860-9	1998	We conclude that periplasmic Cu,Zn SOD contributes to the virulence of Neisseria meningitidis, most likely by reducing the effectiveness of toxic oxygen host defenses.	Oxygen	146-152	superoxide dismutase 1, soluble	Mus musculus	29-38
9840812-9	1998	Transient transfection experiments demonstrate that the HIF3alpha-ARNT interaction can occur in vivo, and that the activity of HIF3alpha is upregulated in response to cobalt chloride or low oxygen tension.	Oxygen	190-196	hypoxia inducible factor 3 subunit alpha	Homo sapiens	56-65
9840812-9	1998	Transient transfection experiments demonstrate that the HIF3alpha-ARNT interaction can occur in vivo, and that the activity of HIF3alpha is upregulated in response to cobalt chloride or low oxygen tension.	Oxygen	190-196	hypoxia inducible factor 3 subunit alpha	Homo sapiens	127-136
9595536-0	1998	The effect of oxygen and carbon dioxide on tumor cell endothelin-1 production.	Oxygen	14-20	endothelin 1	Homo sapiens	54-66
9692838-3	1998	The hypoxia-inducible factor 1 (HIF-1), a transcription factor consisting of the two proteins HIF-1alpha and HIF-1beta, plays a major role in the pleiotropic response observed under low oxygen.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
9692838-3	1998	The hypoxia-inducible factor 1 (HIF-1), a transcription factor consisting of the two proteins HIF-1alpha and HIF-1beta, plays a major role in the pleiotropic response observed under low oxygen.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
9692838-3	1998	The hypoxia-inducible factor 1 (HIF-1), a transcription factor consisting of the two proteins HIF-1alpha and HIF-1beta, plays a major role in the pleiotropic response observed under low oxygen.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
9452126-4	1998	IMCD ET-1 secretion significantly increased after exposure of cultures to 3% O2 (114.1% +/- 4.7% increase over control value) and 0%O2 (171.7% +/- 7.9% increase).	Oxygen	77-79	endothelin 1	Rattus norvegicus	5-9
9452126-4	1998	IMCD ET-1 secretion significantly increased after exposure of cultures to 3% O2 (114.1% +/- 4.7% increase over control value) and 0%O2 (171.7% +/- 7.9% increase).	Oxygen	132-134	endothelin 1	Rattus norvegicus	5-9
9452126-5	1998	ET-1 mRNA levels, as determined by reverse transcription-polymerase chain reaction, also increased 2.5-fold after 24-hour exposure to 0% O2.	Oxygen	137-139	endothelin 1	Rattus norvegicus	0-4
9718071-2	1998	We investigated the mechanisms by which low oxygen tension modulates the expression of VEGF in human aortic vascular smooth muscle cells (h-SMC) in vitro.	Oxygen	44-50	vascular endothelial growth factor A	Homo sapiens	87-91
9595536-3	1998	Exposure of HT29 cells to either 2% O2 or 0.2% O2 significantly reduced ET-1 production compared to cells in normoxia.	Oxygen	36-38	endothelin 1	Homo sapiens	72-76
9595536-3	1998	Exposure of HT29 cells to either 2% O2 or 0.2% O2 significantly reduced ET-1 production compared to cells in normoxia.	Oxygen	47-49	endothelin 1	Homo sapiens	72-76
9595536-4	1998	In contrast, production of ET-1 by DU145 cells was usually unaffected by hypoxia and was even slightly increased in cells exposed to 2% O2 in HEPES-buffered EMEM (HEPES-EMEM).	Oxygen	136-138	endothelin 1	Homo sapiens	27-31
9475660-5	1998	The mean peak oxygen uptake was 22.6 and 15.1 mL x kg(-1) x min(-1) among PA and CO, respectively.	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	60-66
9763211-1	1998	Hypoxia inducible factor 1 (HIF-1) is a transcription factor which is expressed, when mammalian cells are subjected to hypoxia, activating the transcription of genes encoding proteins thought important for maintaining oxygen hemostasis.	Oxygen	218-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
9763211-1	1998	Hypoxia inducible factor 1 (HIF-1) is a transcription factor which is expressed, when mammalian cells are subjected to hypoxia, activating the transcription of genes encoding proteins thought important for maintaining oxygen hemostasis.	Oxygen	218-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
9857660-9	1998	The oxygen uptake at the LT amounted to 1734 +/- 282 ml.min-1 and corresponded to 48% of VO2 max (3726 +/- 363 ml.min-1).	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	56-61
9672927-4	1998	The composition of the FGF (600 ml.min-1) was calculated as follows: oxygen necessary for consumption (60 ml.min-1) plus the remaining FGF in a 1:2 relationship for oxygen.	Oxygen	69-75	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
9672927-4	1998	The composition of the FGF (600 ml.min-1) was calculated as follows: oxygen necessary for consumption (60 ml.min-1) plus the remaining FGF in a 1:2 relationship for oxygen.	Oxygen	165-171	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
9481782-9	1998	In this environment oxidative activity of the sort resulting in the generation of hydrogen peroxide would presumably be suppressed, thereby limiting the requirement for catalase until oxygen tension begins to rise.	Oxygen	184-190	catalase	Homo sapiens	169-177
9857660-9	1998	The oxygen uptake at the LT amounted to 1734 +/- 282 ml.min-1 and corresponded to 48% of VO2 max (3726 +/- 363 ml.min-1).	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	114-119
10453750-7	1998	The total net oxygen consumed throughout the 6 min cycling period at pedalling rates of 40, 60, 80, 100 and 120 rev.min(-1) amounted to 7.727+/-1.197, 7.705+/-1.548, 8.679+/-1.262, 9.945+/-1.435 and 13.720+/-1.862 l, respectively for each pedalling rate.	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
9821247-5	1998	The data obtained permit a conclusion that O2.- participates in the intracellular signal transduction, and is involved in the mechanism of hyperpolarization response of astrocytes to the effect of the inducer of ROS, complement component C5a.	Oxygen	43-45	complement C5a receptor 1	Homo sapiens	238-241
9389755-3	1997	Human keratinocytes apposed to collagens or fibronectin exhibited increased motility when subjected to hypoxic (0.2 or 2% oxygen) conditions compared with normoxic (9 or 20% oxygen) conditions.	Oxygen	122-128	fibronectin 1	Homo sapiens	44-55
9704061-5	1997	To this end, we studied the effects of pentoxifylline on TNF- and G-CSF-induced modulation of neutrophil chemotaxis and O2 release.	Oxygen	120-122	tumor necrosis factor	Homo sapiens	57-60
9388263-1	1997	It has been shown that the relative reaction preference of the C4 thiol ester toward oxygen and nitrogen nucleophiles upon activation by proteinase depends on whether residue 1106 is aspartate or histidine (Dodds, A. W., Ren, X.-D., Willis, A. C., and Law, S. K. A.	Oxygen	85-91	renin	Homo sapiens	221-224
9398185-13	1997	A low-barrier hydrogen bond from PGH NOH to Glu-165 suggests a dual role for Glu-165 in catalysis of proton transfer not only between the C1 and C2 carbons but also between the O1 and O2 oxygens in the interconversion of DHAP and GAP in wild type TIM.	Oxygen	187-194	triosephosphate isomerase 1	Homo sapiens	247-250
9416938-1	1997	In congestive heart failure (CHF), some of the effects of angiotensin-converting enzyme (ACE) inhibitors, such as an increase in exercise oxygen uptake (VO2), are mediated through prostaglandins.	Oxygen	138-144	angiotensin I converting enzyme	Homo sapiens	58-87
9416938-1	1997	In congestive heart failure (CHF), some of the effects of angiotensin-converting enzyme (ACE) inhibitors, such as an increase in exercise oxygen uptake (VO2), are mediated through prostaglandins.	Oxygen	138-144	angiotensin I converting enzyme	Homo sapiens	89-92
9587447-6	1997	Myocardial oxygen consumption is naturally increased during pregnancy and excess intracellular calcium secondary to the beta-1 stimulation occurring with the use of beta-2 mimetic drugs further aggravates matters.	Oxygen	11-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	120-126
9389755-3	1997	Human keratinocytes apposed to collagens or fibronectin exhibited increased motility when subjected to hypoxic (0.2 or 2% oxygen) conditions compared with normoxic (9 or 20% oxygen) conditions.	Oxygen	174-180	fibronectin 1	Homo sapiens	44-55
9548465-1	1997	We previously demonstrated that IL-1beta-mediated induction of the nuclear factor-kappaB (NF-kappaB) transcription factor proceeds through the production of reactive oxygen intermediates in lymphoid cells, while it occurs independently of any oxidative stress in epithelial transformed cells.	Oxygen	166-172	interleukin 1 beta	Homo sapiens	32-40
22358881-5	1997	HIF-1 is an inactive form under a normal oxygen concentration, 4.	Oxygen	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
9473738-8	1997	Incubation of hydroxyurea and Cu,Zn-SOD with xanthine oxidase and hypoxanthine in a system forming O2- --&gt;H2O2 also resulted in appreciable NO production.	Oxygen	99-101	superoxide dismutase 1	Homo sapiens	30-39
9398165-5	1997	The reaction of H2O2 and NHA with nNOS was at least 10-fold slower than the reaction of NADPH, O2, and NHA (Vmax,app = 49 +/- 2 nmol min-1 mg-1 for the reactions with 10 microM added H4B).	Oxygen	18-20	CD59 molecule (CD59 blood group)	Homo sapiens	133-143
9348345-6	1997	Mutant SOD-expressing PC12 cells had higher rates of superoxide (O2-) production under a variety of conditions.	Oxygen	65-68	superoxide dismutase 1	Homo sapiens	7-10
9386153-7	1997	Likewise, myocardial oxygen consumption was lower at rest in contractile reserve-negative (clearance rate of [11C]acetate, 0.043+/-0.012 min(-1)) than in contractile reserve-positive (0.048+/-0.01 min(-1)) and normal segments (0.058+/-0.008 min(-1), P&lt;.02).	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	137-143
9386153-7	1997	Likewise, myocardial oxygen consumption was lower at rest in contractile reserve-negative (clearance rate of [11C]acetate, 0.043+/-0.012 min(-1)) than in contractile reserve-positive (0.048+/-0.01 min(-1)) and normal segments (0.058+/-0.008 min(-1), P&lt;.02).	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9386153-7	1997	Likewise, myocardial oxygen consumption was lower at rest in contractile reserve-negative (clearance rate of [11C]acetate, 0.043+/-0.012 min(-1)) than in contractile reserve-positive (0.048+/-0.01 min(-1)) and normal segments (0.058+/-0.008 min(-1), P&lt;.02).	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	197-203
9386153-8	1997	Myocardial oxygen consumption with dobutamine increased less in contractile reserve-negative (0.060+/-0.013 min(-1)) than in contractile reserve-positive (0.077+/-0.016 min(-1)) and normal segments (0.092+/-0.024 min(-1), P&lt;.0001).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	108-114
9386153-8	1997	Myocardial oxygen consumption with dobutamine increased less in contractile reserve-negative (0.060+/-0.013 min(-1)) than in contractile reserve-positive (0.077+/-0.016 min(-1)) and normal segments (0.092+/-0.024 min(-1), P&lt;.0001).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	169-175
9386153-8	1997	Myocardial oxygen consumption with dobutamine increased less in contractile reserve-negative (0.060+/-0.013 min(-1)) than in contractile reserve-positive (0.077+/-0.016 min(-1)) and normal segments (0.092+/-0.024 min(-1), P&lt;.0001).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	169-175
9462189-5	1997	TNF alpha, IL-6, and IL-8 concentrations were significantly related to gestational age and duration of supplemental oxygen; TNF alpha, IL-6, and IL-8 concentrations also correlated with length of time on the ventilator.	Oxygen	116-122	tumor necrosis factor	Homo sapiens	0-9
9462189-5	1997	TNF alpha, IL-6, and IL-8 concentrations were significantly related to gestational age and duration of supplemental oxygen; TNF alpha, IL-6, and IL-8 concentrations also correlated with length of time on the ventilator.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9352875-0	1997	Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice.	Oxygen	17-23	interleukin 10	Mus musculus	41-55
9352875-10	1997	CONCLUSIONS: Reactive oxygen intermediates are involved in TNF and IL-10 release after reperfusion of cold-preserved livers.	Oxygen	22-28	tumor necrosis factor	Mus musculus	59-62
9352875-10	1997	CONCLUSIONS: Reactive oxygen intermediates are involved in TNF and IL-10 release after reperfusion of cold-preserved livers.	Oxygen	22-28	interleukin 10	Mus musculus	67-72
9382954-2	1997	In an effort to provide a physiologically regulated administration of erythropoietin, we are developing cell lines genetically engineered to release hEpo as a function of oxygen tension.	Oxygen	171-177	erythropoietin	Homo sapiens	149-153
9382954-4	1997	In vitro, these cells showed a threefold increase in hEpo secretion as oxygen levels were shifted from 21% to 1.3% oxygen.	Oxygen	71-77	erythropoietin	Homo sapiens	53-57
9382954-4	1997	In vitro, these cells showed a threefold increase in hEpo secretion as oxygen levels were shifted from 21% to 1.3% oxygen.	Oxygen	115-121	erythropoietin	Homo sapiens	53-57
9382954-6	1997	On average, serum hEpo levels in animals exposed to 7% oxygen were two-fold higher than values seen in their control counterparts kept at 21% oxygen.	Oxygen	55-61	erythropoietin	Homo sapiens	18-22
9382954-6	1997	On average, serum hEpo levels in animals exposed to 7% oxygen were two-fold higher than values seen in their control counterparts kept at 21% oxygen.	Oxygen	142-148	erythropoietin	Homo sapiens	18-22
9382954-7	1997	Similar studies employing rats confirmed that hEpo delivery is regulated as a function of oxygen tension.	Oxygen	90-96	erythropoietin	Homo sapiens	46-50
9382954-8	1997	These results suggest the feasibility of developing an oxygen-regulated, encapsulated cell-based system for hEpo delivery.	Oxygen	55-61	erythropoietin	Homo sapiens	108-112
9374319-10	1997	Net total splanchnic alpha-amino N release and oxygen consumption were decreased (P &lt; .10) with exogenous SRIF, but CSH increased (P &lt; .05) insulin release and oxygen consumption.	Oxygen	166-172	chorionic somatomammotropin hormone	Ovis aries	119-122
9488215-10	1997	CONCLUSIONS: The results suggest that lacidipine may have prevented NF-kappaB-mediated adhesion molecule expression by exerting its effects on oxygen-derived free radicals.	Oxygen	143-149	nuclear factor kappa B subunit 1	Homo sapiens	68-77
9367876-3	1997	As demonstrated by lucigenin-dependent chemiluminescence and superoxide dismutase-inhibitable cytochrome C reduction MCP-4 stimulated the production of reactive oxygen metabolites.	Oxygen	161-167	cytochrome c, somatic	Homo sapiens	94-106
9383735-8	1997	Temperature-induced oxidation of rhuMAb HER2 occurred by the formation of free radicals, and light-induced oxidation of rhuMAb HER2 occurred via single oxygen pathway.	Oxygen	152-158	erb-b2 receptor tyrosine kinase 2	Homo sapiens	127-131
9383735-9	1997	Antioxidants, such as methionine, sodium thiosulfate, catalase, or platinum, prevented Met oxidation in rhuMAb HER2, presumably as free radicals or oxygen scavengers.	Oxygen	148-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-115
22358881-6	1997	Oxygen works as a repressor in the synthesis of HIF-1 protein, 5.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-53
9342391-8	1997	AHB2 protein has a lower affinity for oxygen than AHB1 but is similar to AHB1 in having an unusually low, pH-sensitive oxygen off-rate.	Oxygen	38-44	hemoglobin 2	Arabidopsis thaliana	0-4
9406146-8	1997	These developmental anomalies are thought to be partly due to a direct action of ACE inhibitors on the fetal renin-angiotensin system and partly due to the ischemia resulting from maternal hypotension and decreases in fetal-placental blood flow and oxygen/nutrient delivery to the fetus.	Oxygen	249-255	angiotensin I converting enzyme	Homo sapiens	81-84
21235898-7	1997	In addition to expanding the vasculature at sites where existing vessels have been occluded or obliterated, VEGF also functions to match the vascular density according to development and physiologic increases in oxygen consumption.	Oxygen	212-218	vascular endothelial growth factor A	Homo sapiens	108-112
21235898-8	1997	Fine adjustment of the vasculature includes a step of oxygen-regulated vascular pruning mediated by VEGF in its capacity as a survival factor for newly formed vessels.	Oxygen	54-60	vascular endothelial growth factor A	Homo sapiens	100-104
9342391-8	1997	AHB2 protein has a lower affinity for oxygen than AHB1 but is similar to AHB1 in having an unusually low, pH-sensitive oxygen off-rate.	Oxygen	119-125	hemoglobin 2	Arabidopsis thaliana	0-4
9334359-0	1997	Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis.	Oxygen	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
9334359-8	1997	These results support a model where IL-8 expression is initiated early in astrocytoma development through induction by inflammatory stimuli and later in tumor progression increases due to reduced microenvironmental oxygen pressure.	Oxygen	215-221	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9359410-2	1997	The up-regulation of VEGF expression in response to reduced oxygen tension occurs through transcriptional and post-transcriptional mechanisms.	Oxygen	60-66	vascular endothelial growth factor A	Homo sapiens	21-25
9359410-3	1997	To investigate the molecular mechanisms of transcriptional activation by hypoxia (1% oxygen), fine mapping of a hypoxia-responsive region of the human VEGF promoter was carried out using luciferase reporter-gene constructs in C6 glioma cells.	Oxygen	85-91	vascular endothelial growth factor A	Homo sapiens	151-155
9372215-9	1997	These cells which overexpress catalase or SOD will help to determine the specific role of H2O2 or O2- in the deleterious effects of a number of toxins.	Oxygen	92-94	catalase	Homo sapiens	30-38
9344593-7	1997	Measurements of ROS production during PH indicate that overexpression of SOD leads to the decreased production of O2- and elevation of H2O2.	Oxygen	114-116	superoxide dismutase 1	Homo sapiens	73-76
9369240-4	1997	Such stimulation may have physiological significance as 1,3-bis-phosphoglycerate, the product of GAPDH, isomerises to 2,3-bis-phosphoglycerate, an allosteric effector that decreases the oxygen affinity of hemoglobin, thus providing a feedback loop.	Oxygen	186-192	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	97-102
9345297-3	1997	The superoxide radical generated was completely scavenged by SOD during the late phase of TSH-treatment, presumably as an adaptive measure to check the oxygen burst.	Oxygen	152-158	superoxide dismutase 1	Homo sapiens	61-64
9341598-13	1997	An intermediate but significant increase in vascular endothelial growth factor/vascular permeability factor (733 +/- 35 pg/mL at 24 hours and 2,675 +/- 864 pg/mL at 48 hours) was observed with 1% O2 compared with normoxic controls.	Oxygen	196-198	vascular endothelial growth factor A	Homo sapiens	44-78
9357508-3	1997	According to an early model suggested by Browse and Burnand, pericapillary fibrin cuffs, developing as a result of venous hypertension and extravasation of fibrinogen, act as a barrier to the diffusion of oxygen and nutrients; ultimately, tissue anoxia, cell death, and ulceration would follow.	Oxygen	205-211	fibrinogen beta chain	Homo sapiens	156-166
9338425-14	1997	The critical O2 extraction ratio was also higher in the SIN-1 group than in the other groups (58.7 +/- 10.6 vs. 42.2 +/- 7.6% in controls, P &lt; 0.05; 43.0 +/- 15.5% in L-NMMA group, P = not significant).	Oxygen	13-15	MAPK associated protein 1	Homo sapiens	56-61
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	CD34 molecule	Homo sapiens	107-111
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	erythropoietin	Homo sapiens	251-265
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	erythropoietin	Homo sapiens	267-270
9311399-8	1997	In the lavage fluid, concentration of IL-6 was higher in the oxygen-exposed nostril (40.5 [11-128] pg/ml) than in the non-exposed one (7 [0-34] pg/ml; P &lt; 0.05).	Oxygen	61-67	interleukin 6	Homo sapiens	38-42
9333325-4	1997	In this way, adriamycin provides a kinetic mechanism for the one-electron reduction of oxygen by flavoenzymes such as NADPH-cytochrome P450 reductase and mitochondrial NADH dehydrogenase.	Oxygen	87-93	cytochrome p450 oxidoreductase	Homo sapiens	118-149
9361245-4	1997	RESULTS: S-nitroso-N-acetylpenicillamine (SNAP), carbachol, and bradykinin at doses of 10(-7) to 10(-4) mol/L concentration significantly suppressed tissue O2 consumption both in the absence and presence of 2,4-dinitrophenol (1 mmol/L), a mitochondrial uncoupler.	Oxygen	156-158	kininogen 1	Canis lupus familiaris	64-74
9361245-7	1997	The inhibitory effect on tissue O2 consumption in response to carbachol and bradykinin became significantly smaller in skeletal muscle from dogs with pacing-induced heart failure, but the effects of SNAP were unchanged.	Oxygen	32-34	kininogen 1	Canis lupus familiaris	76-86
9369046-9	1997	It was concluded in this study that LFA using the FGF of 600 ml.min-1 with setting of 3% sevoflurane, 50% oxygen and nitrous oxide, could be performed safely without risks such as hypoxia and severe delay of induction for patients weighing 53 +/- 5 kg for a duration of 5 hours.	Oxygen	106-112	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
9754325-0	1997	Tyrosine hydroxylase: mechanisms of oxygen radical formation.	Oxygen	36-42	tyrosine hydroxylase	Homo sapiens	0-20
9754325-1	1997	A new mechanism of oxygen radical formation in dopaminergic neurons is proposed, based on the oxidative mechanism of tyrosine hydroxylase.	Oxygen	19-25	tyrosine hydroxylase	Homo sapiens	117-137
9278421-10	1997	The effect of proteasome inhibitors on the normoxic induction of HIF-1 binding activity was mimicked by the thiol reducing agent N-(2-mercaptopropionyl)-glycine and by the oxygen radical scavenger 2-acetamidoacrylic acid.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
9311502-7	1997	During exercise, the arterial ET-1 levels were significantly correlated with arterial oxygen (Pa,O2) (r = -0.6, p = 0.04), alveolar-arterial oxygen difference (r = 0.8, p = 0.01), and Ppa (r = 0.6, p = 0.04) in ILD patients, but not in those with emphysema.	Oxygen	86-92	endothelin 1	Homo sapiens	30-34
9321887-5	1997	In addition, LPS and IL-1 beta (1 microgram/kg) inhibited the increase in EPO mRNA and plasma EPO levels when administered to rats before hypoxia exposure (8% O2 in the inspiratory gas).	Oxygen	159-161	interleukin 1 beta	Rattus norvegicus	21-30
9332317-6	1997	We also used oligonucleotides antisense to the Bcr gene mRNA to inhibit expression of the gene and evaluate its function in PMN, following the recent observation that PMN from Bcr-null mutant mice produced increased amounts of reactive oxygen metabolites upon activation.	Oxygen	236-242	BCR activator of RhoGEF and GTPase	Mus musculus	47-50
9332317-6	1997	We also used oligonucleotides antisense to the Bcr gene mRNA to inhibit expression of the gene and evaluate its function in PMN, following the recent observation that PMN from Bcr-null mutant mice produced increased amounts of reactive oxygen metabolites upon activation.	Oxygen	236-242	BCR activator of RhoGEF and GTPase	Mus musculus	176-179
9311502-7	1997	During exercise, the arterial ET-1 levels were significantly correlated with arterial oxygen (Pa,O2) (r = -0.6, p = 0.04), alveolar-arterial oxygen difference (r = 0.8, p = 0.01), and Ppa (r = 0.6, p = 0.04) in ILD patients, but not in those with emphysema.	Oxygen	97-99	endothelin 1	Homo sapiens	30-34
9311502-7	1997	During exercise, the arterial ET-1 levels were significantly correlated with arterial oxygen (Pa,O2) (r = -0.6, p = 0.04), alveolar-arterial oxygen difference (r = 0.8, p = 0.01), and Ppa (r = 0.6, p = 0.04) in ILD patients, but not in those with emphysema.	Oxygen	141-147	endothelin 1	Homo sapiens	30-34
9350435-7	1997	These results suggest that active oxygen radicals mainly react with the protein moiety rather than the carbohydrate moiety of EPO.	Oxygen	34-40	erythropoietin	Homo sapiens	126-129
9350435-10	1997	The role of oligosaccharides in EPO may be to protect the protein structure from active oxygen radicals.	Oxygen	88-94	erythropoietin	Homo sapiens	32-35
9311513-2	1997	The aim of this study was to determine whether the recombinant form of SLPI (rSLPI) and alpha 1-PI show different grades of loss of inhibitory activity when exposed to reactive oxygen metabolites.	Oxygen	177-183	secretory leukocyte peptidase inhibitor	Homo sapiens	71-75
9311513-2	1997	The aim of this study was to determine whether the recombinant form of SLPI (rSLPI) and alpha 1-PI show different grades of loss of inhibitory activity when exposed to reactive oxygen metabolites.	Oxygen	177-183	serpin family A member 1	Homo sapiens	88-98
9329011-0	1997	Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade.	Oxygen	15-21	selectin P	Rattus norvegicus	99-109
9291182-3	1997	In human PTE, hypoxia (1% O2, 24 hr) increased total collagen production (15%), decreased MMP-2 activity (55% +/- 13%; control = 100%) and increased tissue inhibitor of metalloproteinase-1 (TIMP-1) protein.	Oxygen	26-28	TIMP metallopeptidase inhibitor 1	Homo sapiens	149-188
9291182-3	1997	In human PTE, hypoxia (1% O2, 24 hr) increased total collagen production (15%), decreased MMP-2 activity (55% +/- 13%; control = 100%) and increased tissue inhibitor of metalloproteinase-1 (TIMP-1) protein.	Oxygen	26-28	TIMP metallopeptidase inhibitor 1	Homo sapiens	190-196
9300527-3	1997	Superoxide dismutase (SOD) is a key enzyme which scavenges oxygen radicals.	Oxygen	59-65	superoxide dismutase 1	Homo sapiens	0-20
9360416-1	1997	The whole blood oxygen affinity of a Negro carrier of SC disease was found to be characterized by some right-shifted p50 and clearly increased Bohr effect, whereas the isolated and purified Hb-S and Hb-C exhibited slight deficiencies mainly of the Bohr effect.	Oxygen	16-22	nuclear factor kappa B subunit 1	Homo sapiens	117-120
9294870-1	1997	Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide, Lys-136, along with the adjacent residues Glu-132 and Glu-133, forms a proposed electrostatic triad contributing to substrate recognition.	Oxygen	191-197	superoxide dismutase 1	Homo sapiens	24-50
9294870-1	1997	Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide, Lys-136, along with the adjacent residues Glu-132 and Glu-133, forms a proposed electrostatic triad contributing to substrate recognition.	Oxygen	191-197	superoxide dismutase 1	Homo sapiens	52-61
9306333-0	1997	Beyond erythropoietin: the oxygen sensor.	Oxygen	27-33	erythropoietin	Homo sapiens	7-21
9300527-3	1997	Superoxide dismutase (SOD) is a key enzyme which scavenges oxygen radicals.	Oxygen	59-65	superoxide dismutase 1	Homo sapiens	22-25
9235919-10	1997	Transcriptional activity of GAL4/HIF-1alpha fusion proteins was increased in cells exposed to 1% O2, cobalt chloride, or desferrioxamine, each of which also increased levels of endogenous HIF-1alpha protein but did not affect fusion protein levels.	Oxygen	97-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
9268299-5	1997	The 2.9 A structure determination of the catalytic domain of human tPA in complex with the bis-benzamidine inhibitor 2, 7-bis-(4-amidinobenzylidene)-cycloheptan-1-one reveals a three-site interaction, salt bridge formation of the proximal amidino group of the inhibitor with Asp189 in the primary specificity pocket, extensive hydrophobic surface burial, and a weak electrostatic interaction between the distal amidino group of the inhibitor and two carbonyl oxygens of the protein.	Oxygen	459-466	plasminogen activator, tissue type	Homo sapiens	67-70
9264557-6	1997	Our results suggest that CuZnSOD-deficient cells are more sensitive to oxygen toxicity than are MnSOD-deficient cells, that paraquat causes free radical-induced damage in both the mitochondria and cytoplasm, and that SOD compartmentalized in the cytosol cannot compensate for the loss of SOD in the mitochondria and vice versa.	Oxygen	71-77	superoxide dismutase 1, soluble	Mus musculus	25-32
9264557-6	1997	Our results suggest that CuZnSOD-deficient cells are more sensitive to oxygen toxicity than are MnSOD-deficient cells, that paraquat causes free radical-induced damage in both the mitochondria and cytoplasm, and that SOD compartmentalized in the cytosol cannot compensate for the loss of SOD in the mitochondria and vice versa.	Oxygen	71-77	superoxide dismutase 1, soluble	Mus musculus	29-32
9426913-0	1997	In the early stage of major burns, is there a correlation between survival, interleukin-6 levels and oxygen delivery and consumption?	Oxygen	101-107	interleukin 6	Homo sapiens	76-89
9268320-1	1997	Fas-driven apoptosis in Jurkat cells results in the inactivation of cytochrome c with cessation of oxygen consumption.	Oxygen	99-105	cytochrome c, somatic	Homo sapiens	68-80
9252381-3	1997	To test if NF-kappaB can protect from necrotic cell death caused by high levels of molecular O2 (hyperoxia), we exposed human alveolar epithelial (A549) cells to hyperoxia.	Oxygen	93-95	nuclear factor kappa B subunit 1	Homo sapiens	11-20
9285111-12	1997	The results of this study suggested that reactive oxygen metabolites may play a pathogenetic role in the both benign and malignant tumor development, which is reflected by the change in SOD activity, and in trace element concentrations.	Oxygen	50-56	superoxide dismutase 1	Homo sapiens	186-189
9247511-3	1997	BACKGROUND: The oxygen demand/supply ratio of the myocardium is influenced by angiotensin II as a result of its arterial vasoconstrictive and inotropic effects and through its interaction with the sympathetic nervous system.	Oxygen	16-22	angiotensinogen	Homo sapiens	78-92
9247528-7	1997	Peak oxygen consumption (VO2) (r = 0.63), fasting triglycerides (r = -0.62) and age (r = -0.46, all p &lt; 0.001) predicted insulin sensitivity independently.	Oxygen	5-11	insulin	Homo sapiens	124-131
9235919-10	1997	Transcriptional activity of GAL4/HIF-1alpha fusion proteins was increased in cells exposed to 1% O2, cobalt chloride, or desferrioxamine, each of which also increased levels of endogenous HIF-1alpha protein but did not affect fusion protein levels.	Oxygen	97-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	188-198
9307123-7	1997	The membrane potential recovered after reintroduction of oxygen and glucose in low Ca2+, low Cl-, or K+-rich medium and in TTX- or tetraethylammonium-containing medium, but not in low Na+ or low K+ medium and in flunarizine- or nifedipine-containing medium.	Oxygen	57-63	carbonic anhydrase 2	Rattus norvegicus	83-86
9387095-4	1997	These and other observations suggest that the normal cell responds physiologically to changes in oxygen tension or the availability of glucose by altering glycolysis through the ChoRE, which hypothetically binds c-Myc, HIF-1, or related factors.	Oxygen	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	219-224
9258252-1	1997	Interleukin-8 (IL-8) is an important cytokine in inflammatory processes by functioning as a chemoattractant and as an activator of oxygen metabolism.	Oxygen	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9258252-1	1997	Interleukin-8 (IL-8) is an important cytokine in inflammatory processes by functioning as a chemoattractant and as an activator of oxygen metabolism.	Oxygen	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9508665-7	1997	Additional parameters such as effective hemoglobin concentration ceHb (equivalent of oxygen capacity) and the hemoglobin oxygen affinity (p50) inform us of the oxygen supply to the tissue.	Oxygen	121-127	nuclear factor kappa B subunit 1	Homo sapiens	138-141
9441906-8	1997	In the presence of catalase, approximately 50% of the oxygen consumed was restored, indicating stoichiometric conversion of O2 to H2O2 during oxidation of GSH by peroxynitrite salt.	Oxygen	54-60	catalase	Homo sapiens	19-27
9441906-8	1997	In the presence of catalase, approximately 50% of the oxygen consumed was restored, indicating stoichiometric conversion of O2 to H2O2 during oxidation of GSH by peroxynitrite salt.	Oxygen	124-126	catalase	Homo sapiens	19-27
9284430-3	1997	An increased production of oxygen-free radicals leads to increased transcription of redox-sensitive genes, which increases the expression of vascular cell adhesion molecule-1 (VCAM-1) in the endothelium, resulting in increased recruitment of monocytes to the endothelium.	Oxygen	27-33	vascular cell adhesion molecule 1	Homo sapiens	141-174
9284430-3	1997	An increased production of oxygen-free radicals leads to increased transcription of redox-sensitive genes, which increases the expression of vascular cell adhesion molecule-1 (VCAM-1) in the endothelium, resulting in increased recruitment of monocytes to the endothelium.	Oxygen	27-33	vascular cell adhesion molecule 1	Homo sapiens	176-182
9288847-7	1997	The rates of synthesis of oxygen-regulated proteins (GRP78, GRP94, HSP70 and HSP90) were transiently perturbed to a similar extent in all lines after hypoxia treatment.	Oxygen	26-32	heat shock protein family A (Hsp70) member 5	Homo sapiens	53-58
9508665-7	1997	Additional parameters such as effective hemoglobin concentration ceHb (equivalent of oxygen capacity) and the hemoglobin oxygen affinity (p50) inform us of the oxygen supply to the tissue.	Oxygen	121-127	nuclear factor kappa B subunit 1	Homo sapiens	138-141
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	erythropoietin	Homo sapiens	222-236
9257692-0	1997	Active oxygen species mediate the solar ultraviolet radiation-dependent increase in the tumour suppressor protein p53 in human skin fibroblasts.	Oxygen	7-13	tumor protein p53	Homo sapiens	114-117
9257692-5	1997	Simulated solar UV radiation increased p53, and agents that scavenge active oxygen species, N-acetylcysteine, ascorbate and alpha-tocopherol, inhibited the increase.	Oxygen	76-82	tumor protein p53	Homo sapiens	39-42
9240582-9	1997	Infants exposed to tumor necrosis factor-alpha remained on supplemental oxygen and assisted ventilation longer and had longer hospital stays compared with nonexposed infants.	Oxygen	72-78	tumor necrosis factor	Homo sapiens	19-46
11669965-5	1997	With trace amounts of oxygen, the reaction of Co(II)(TPP) with hydroxylamine led to the formation of a stable cobalt(III)-bis(hydroxylamine) complex.	Oxygen	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
11669965-5	1997	With trace amounts of oxygen, the reaction of Co(II)(TPP) with hydroxylamine led to the formation of a stable cobalt(III)-bis(hydroxylamine) complex.	Oxygen	22-28	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	117-120
9258453-4	1997	The significant suppression by the coaddition of superoxide dismutase (SOD) and catalase to Cys indicated that Cys was easily oxidized by oxygen and simultaneously generates a large amount of active oxygens.	Oxygen	138-144	catalase	Rattus norvegicus	80-88
9258453-4	1997	The significant suppression by the coaddition of superoxide dismutase (SOD) and catalase to Cys indicated that Cys was easily oxidized by oxygen and simultaneously generates a large amount of active oxygens.	Oxygen	199-206	catalase	Rattus norvegicus	80-88
9225738-3	1997	In vivo hypoxia (5% O2/95% N2 for 30 min) induced mild degenerative neuronal changes (shrunken and eosinophilic somata with picnotic nuclei) in neurons of the CA3, the hilus of the dentate gyrus (DG) and the DG, but not in the CA1.	Oxygen	20-22	carbonic anhydrase 3	Homo sapiens	159-162
9278140-1	1997	The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia).	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
9278140-1	1997	The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia).	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
9278140-3	1997	Examples of these oxy-genes include erythropoietin, a hormone regulating erythropoiesis and hence the oxygen transport capacity, and vascular endothelial growth factor, a potent inducer of angiogenesis leading to increased blood capillary density.	Oxygen	102-108	erythropoietin	Homo sapiens	36-50
9315342-1	1997	Norepinephrine and angiotensin II are potent vasoconstrictors and stimulate thermogenesis (oxygen uptake) as well as lactate and glycerol efflux in the constant-flow perfused rat hind limb at rest.	Oxygen	91-97	angiotensinogen	Rattus norvegicus	19-33
9361705-4	1997	b) In the presence of Ca2+, the increase in oxygen uptake caused by the infusion of lactate plus pyruvate at a ratio equal to 10 was the most pronounced one; in Ca(2+)-free perfusion the increase in oxygen uptake caused by lactate plus pyruvate infusion tended to be higher for all lactate to pyruvate ratios; the most pronounced difference was observed for lactate/pyruvate ratio equal to 1. c) In the presence of Ca2+ the effects of glucagon on gluconeogenesis showed a positive correlation with the lactate to pyruvate ratios; for a ratio equal to 0.01 no stimulation occurred, but in the 0.1 to 100 range stimulation increased progressively, producing a clear parabolic dependence between the effects of glucagon and the lactate to pyruvate ratio.	Oxygen	44-50	carbonic anhydrase 2	Rattus norvegicus	22-25
9361705-4	1997	b) In the presence of Ca2+, the increase in oxygen uptake caused by the infusion of lactate plus pyruvate at a ratio equal to 10 was the most pronounced one; in Ca(2+)-free perfusion the increase in oxygen uptake caused by lactate plus pyruvate infusion tended to be higher for all lactate to pyruvate ratios; the most pronounced difference was observed for lactate/pyruvate ratio equal to 1. c) In the presence of Ca2+ the effects of glucagon on gluconeogenesis showed a positive correlation with the lactate to pyruvate ratios; for a ratio equal to 0.01 no stimulation occurred, but in the 0.1 to 100 range stimulation increased progressively, producing a clear parabolic dependence between the effects of glucagon and the lactate to pyruvate ratio.	Oxygen	44-50	carbonic anhydrase 2	Rattus norvegicus	415-418
9361705-4	1997	b) In the presence of Ca2+, the increase in oxygen uptake caused by the infusion of lactate plus pyruvate at a ratio equal to 10 was the most pronounced one; in Ca(2+)-free perfusion the increase in oxygen uptake caused by lactate plus pyruvate infusion tended to be higher for all lactate to pyruvate ratios; the most pronounced difference was observed for lactate/pyruvate ratio equal to 1. c) In the presence of Ca2+ the effects of glucagon on gluconeogenesis showed a positive correlation with the lactate to pyruvate ratios; for a ratio equal to 0.01 no stimulation occurred, but in the 0.1 to 100 range stimulation increased progressively, producing a clear parabolic dependence between the effects of glucagon and the lactate to pyruvate ratio.	Oxygen	199-205	carbonic anhydrase 2	Rattus norvegicus	22-25
9361705-4	1997	b) In the presence of Ca2+, the increase in oxygen uptake caused by the infusion of lactate plus pyruvate at a ratio equal to 10 was the most pronounced one; in Ca(2+)-free perfusion the increase in oxygen uptake caused by lactate plus pyruvate infusion tended to be higher for all lactate to pyruvate ratios; the most pronounced difference was observed for lactate/pyruvate ratio equal to 1. c) In the presence of Ca2+ the effects of glucagon on gluconeogenesis showed a positive correlation with the lactate to pyruvate ratios; for a ratio equal to 0.01 no stimulation occurred, but in the 0.1 to 100 range stimulation increased progressively, producing a clear parabolic dependence between the effects of glucagon and the lactate to pyruvate ratio.	Oxygen	199-205	carbonic anhydrase 2	Rattus norvegicus	415-418
9361705-6	1997	e) The effects of glucagon on oxygen uptake in the presence of Ca2+ showed a parabolic relationship with the lactate to pyruvate ratios which was closely similar to that found in the case of gluconeogenesis; the only difference was that inhibition rather than stimulation of oxygen uptake was observed for a lactate to pyruvate ratio equal to 0.01; progressive stimulation was observed in the 0.1 to 100 range.	Oxygen	30-36	carbonic anhydrase 2	Rattus norvegicus	63-66
9361705-6	1997	e) The effects of glucagon on oxygen uptake in the presence of Ca2+ showed a parabolic relationship with the lactate to pyruvate ratios which was closely similar to that found in the case of gluconeogenesis; the only difference was that inhibition rather than stimulation of oxygen uptake was observed for a lactate to pyruvate ratio equal to 0.01; progressive stimulation was observed in the 0.1 to 100 range.	Oxygen	275-281	carbonic anhydrase 2	Rattus norvegicus	63-66
9298775-4	1997	Mean maximal oxygen uptake was 51.3 +/- 2.3 ml x kg(-1) x min(-1) at T1 and was at the same level at T2.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	58-64
9282313-0	1997	Effects of iron chelates on the transferrin-free culture of rat dermal fibroblasts through active oxygen generation.	Oxygen	98-104	transferrin	Rattus norvegicus	32-43
9298775-5	1997	At T3 and T4 maximal oxygen uptake was increased to 53.8 +/- 2.7 and 53.5 +/- 2.9 ml x kg(-1) x min(-1) (p &lt; 0.05), respectively.	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	96-102
9251504-7	1997	T-wave amplitude on electrocardiaogram (ECG) and oxygen partial pressure in arterial blood decreased at 10 and 15 micrograms.kg-1.min-1.	Oxygen	49-55	CD59 molecule (CD59 blood group)	Homo sapiens	130-135
9254911-6	1997	Application of the charge state characterization schemes to the hydroxyethylene and statine transition state inhibitors of renin in the training set suggests a monoprotonation state of the two active-site aspartate residues, where the lone proton resides on the outer carboxylate oxygen of Asp226 is most likely.	Oxygen	280-286	renin	Homo sapiens	123-128
9236909-0	1997	Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production.	Oxygen	132-134	formyl peptide receptor 1	Homo sapiens	100-104
9236909-3	1997	Umbilical cord blood-derived eosinophils responded to fMLP (0.01 nM to 3 microM) with a concentration-dependent production of O2- (EC50 = 63.1 +/- 17.2 nM; Emax = 71.0 +/- 6.2 pmol/min/10(6) cells).	Oxygen	126-128	formyl peptide receptor 1	Homo sapiens	54-58
9236909-4	1997	O2- production was correlated with an fMLP concentration-dependent increase in [Ca2+]i (EC50 = 32.5 +/- 14.9 nM; Emax = 200.0 +/- 23.9 nM).	Oxygen	0-2	formyl peptide receptor 1	Homo sapiens	38-42
9224688-6	1997	and O2.-, which generated lipid peroxidation products, also initiated AP1 activation, whereas LDL modified by OH.	Oxygen	4-6	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-73
9218699-7	1997	L-NMMA enhanced the increase in portal pressure and decrease in O2 consumption caused by endothelin-1.	Oxygen	64-66	endothelin 1	Rattus norvegicus	89-101
9196034-8	1997	Catalase inhibited the .OH radical generation while H2O2 enhanced it, indicating that the .OH radical was generated via a Fenton-like reaction, H2O2 being generated as an intermediate in the reduction of molecular oxygen.	Oxygen	214-220	catalase	Homo sapiens	0-8
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	280-286	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	145-150
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	147-152
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	340-346	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	145-150
9169434-9	1997	The hypoxic genes COX5b and CYC7 are not expressed until the oxygen concentration is below 0.5 microM O2.	Oxygen	61-67	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	18-23
9192316-9	1997	The average rate of oxygen uptake over the quadriceps muscle at maximal work, 353 ml min-1 kg-1, corresponded to a Krebs cycle rate of 4.6 mumol min-1 g-1.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	85-95
9169434-9	1997	The hypoxic genes COX5b and CYC7 are not expressed until the oxygen concentration is below 0.5 microM O2.	Oxygen	102-104	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	18-23
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Oxygen	110-116	nitric oxide synthase 2, inducible	Mus musculus	36-67
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Oxygen	110-116	nitric oxide synthase 2, inducible	Mus musculus	69-73
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Oxygen	110-116	nitric oxide synthase 2, inducible	Mus musculus	75-80
9173956-8	1997	O2 deficit decreased between WT1 and WT2 in H only (P &lt; 0.01).	Oxygen	0-2	WT1 transcription factor	Homo sapiens	29-32
9223888-8	1997	Inhalation of 3 l.min-1 oxygen via a mask is sufficient to prevent such postoperative hypoxemia.	Oxygen	24-30	CD59 molecule (CD59 blood group)	Homo sapiens	18-23
9223111-1	1997	The human Cu/Zn superoxide dismutase (hSOD-1) gene, catalyses the dismutation of O2 to H2O2 and O2.	Oxygen	81-83	superoxide dismutase 1	Homo sapiens	10-36
9223111-1	1997	The human Cu/Zn superoxide dismutase (hSOD-1) gene, catalyses the dismutation of O2 to H2O2 and O2.	Oxygen	81-83	superoxide dismutase 1	Homo sapiens	38-44
9223111-1	1997	The human Cu/Zn superoxide dismutase (hSOD-1) gene, catalyses the dismutation of O2 to H2O2 and O2.	Oxygen	89-91	superoxide dismutase 1	Homo sapiens	10-36
9223111-1	1997	The human Cu/Zn superoxide dismutase (hSOD-1) gene, catalyses the dismutation of O2 to H2O2 and O2.	Oxygen	89-91	superoxide dismutase 1	Homo sapiens	38-44
9219204-5	1997	Both the beta 1 and the combined beta 1, beta 2-adrenoreceptor antagonists reduced resting oxygen consumption to a similar extent (0.247 +/- 0.007 L.min-1 placebo, vs 0.218 +/- 0.007 L.min-1 beta 1-antagonism, vs 0.226 +/- 0.007 L.min-1 beta 1, beta 2-antagonism; P &lt; 0.05).	Oxygen	91-97	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	9-62
9219204-5	1997	Both the beta 1 and the combined beta 1, beta 2-adrenoreceptor antagonists reduced resting oxygen consumption to a similar extent (0.247 +/- 0.007 L.min-1 placebo, vs 0.218 +/- 0.007 L.min-1 beta 1-antagonism, vs 0.226 +/- 0.007 L.min-1 beta 1, beta 2-antagonism; P &lt; 0.05).	Oxygen	91-97	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	9-15
9219204-5	1997	Both the beta 1 and the combined beta 1, beta 2-adrenoreceptor antagonists reduced resting oxygen consumption to a similar extent (0.247 +/- 0.007 L.min-1 placebo, vs 0.218 +/- 0.007 L.min-1 beta 1-antagonism, vs 0.226 +/- 0.007 L.min-1 beta 1, beta 2-antagonism; P &lt; 0.05).	Oxygen	91-97	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	33-39
9219218-11	1997	CONCLUSIONS: A remodeling of capillary network which would increase the oxygen transport capacity to cardiac tissues was produced in left ventricular tissues by intravenous injection of vasopressin.	Oxygen	72-78	arginine vasopressin	Rattus norvegicus	186-197
9198259-6	1997	The physical performance during an ergometer test corresponded to a maximal oxygen consumption of 21 ml/kg-1 x min-1.	Oxygen	76-82	CD59 molecule (CD59 blood group)	Homo sapiens	111-116
9441132-6	1997	In trying to explain the variability in the clinical expression of A1AT-deficiency and the development of emphysema, the importance of changes to A1AT, SLPI and elafin molecules induced by smoking and/or oxygen free radicals has been considered.	Oxygen	204-210	serpin family A member 1	Homo sapiens	67-71
27406959-2	1997	The potentially toxic reduced oxygen intermediates (ROI), hydrogen peroxide (H2O2) and superoxide anion (O2(.-)), are generated when reduced AOX becomes oxidized by molecular oxygen, raising the possibility for involvement of AOX in pathophysiology.	Oxygen	30-36	aldehyde oxidase 1	Homo sapiens	141-144
27406959-2	1997	The potentially toxic reduced oxygen intermediates (ROI), hydrogen peroxide (H2O2) and superoxide anion (O2(.-)), are generated when reduced AOX becomes oxidized by molecular oxygen, raising the possibility for involvement of AOX in pathophysiology.	Oxygen	30-36	aldehyde oxidase 1	Homo sapiens	226-229
27406959-2	1997	The potentially toxic reduced oxygen intermediates (ROI), hydrogen peroxide (H2O2) and superoxide anion (O2(.-)), are generated when reduced AOX becomes oxidized by molecular oxygen, raising the possibility for involvement of AOX in pathophysiology.	Oxygen	79-81	aldehyde oxidase 1	Homo sapiens	141-144
9199517-3	1997	Pre-perfusion of scala tympani with L-methyl arginine (L-MA), which inhibits the release of NO, or superoxide dismutase (SOD), an O2-scavenger, conferred marked protection upon the cochlea from the lesions caused by NO donors.	Oxygen	130-132	superoxide dismutase 1	Homo sapiens	121-124
27406959-2	1997	The potentially toxic reduced oxygen intermediates (ROI), hydrogen peroxide (H2O2) and superoxide anion (O2(.-)), are generated when reduced AOX becomes oxidized by molecular oxygen, raising the possibility for involvement of AOX in pathophysiology.	Oxygen	175-181	aldehyde oxidase 1	Homo sapiens	141-144
27406959-2	1997	The potentially toxic reduced oxygen intermediates (ROI), hydrogen peroxide (H2O2) and superoxide anion (O2(.-)), are generated when reduced AOX becomes oxidized by molecular oxygen, raising the possibility for involvement of AOX in pathophysiology.	Oxygen	175-181	aldehyde oxidase 1	Homo sapiens	226-229
9194664-0	1997	The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics.	Oxygen	76-82	vascular endothelial growth factor A	Homo sapiens	129-163
9165972-3	1997	The delivery of oxygen at 21.min-1 via nasal cannulae was shown to be superior to a method which directed oxygen from under the surgical drapes.	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	29-34
9163701-8	1997	NADH consumption was accompanied by dicumarol-sensitive oxygen uptake both with the purified enzyme and with cytosol from human melanoma cells with high levels of DT-diaphorase activity.	Oxygen	56-62	NAD(P)H quinone dehydrogenase 1	Homo sapiens	163-176
9179920-3	1997	Since VEGF is known to be upregulated by hypoxia, the expression pattern of VEGF would provide further clues to the oxygen status in the placentae at the time of sampling, presently a subject under great debate.	Oxygen	116-122	vascular endothelial growth factor A	Homo sapiens	76-80
11669790-3	1997	The active species in oxygen uptake is the CoL(2) complex already suggested in the Co(II)-histamine-O(2) system; however, in the case of pseudopeptides, both CoLH(-)(1) and CoL(2)H(-)(1) complexes can take up oxygen.	Oxygen	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9111021-2	1997	To identify regions of HIF-1 subunits responsible for oxygen-regulated activity, we constructed chimeric genes in which portions of coding sequence from HIF-1 genes were either linked to a heterologous DNA binding domain or encoded between such a DNA binding domain and a constitutive activation domain.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
11669790-3	1997	The active species in oxygen uptake is the CoL(2) complex already suggested in the Co(II)-histamine-O(2) system; however, in the case of pseudopeptides, both CoLH(-)(1) and CoL(2)H(-)(1) complexes can take up oxygen.	Oxygen	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9131041-1	1997	The superoxide (O2-)-generating NADPH oxidase of phagocytic cells is composed of a membrane-bound flavocytochrome (cytochrome b-559) and three cytosolic components, p47-phox, p67-phox, and the small GTPase rac-1 (or 2).	Oxygen	16-18	CD33 molecule	Homo sapiens	175-178
9109387-5	1997	These results show that irradiation with visible light markedly enhances the oxygen-dependent NO release from SIN-1.	Oxygen	77-83	MAPK associated protein 1	Homo sapiens	110-115
9110920-5	1997	Exposure to 95% O2 activated resting AM to produce significantly increased amounts of IL-1beta and IL-6.	Oxygen	16-18	interleukin-6	Macaca fascicularis	99-103
9125405-9	1997	By comparison with previous studies using P- and Q-type blockers to attempt neuroprotection against the same deprivation insult, the rank order in which specific Ca2+-channel types contribute to neuronal death due to oxygen and glucose deprivation was determined to be Q &gt; N &gt;&gt; P &gt; L.	Oxygen	217-223	carbonic anhydrase 2	Rattus norvegicus	162-165
9275278-5	1997	Peroxidase efficiency of ferritin in the TMB oxidation by hydrogen peroxide (kcat/km) is characterized by a value 2.82.10(3) M-1.sec-1 comparable with ferroxidase efficiency of apoferritin in the oxidation of Fe2+ by oxygen.	Oxygen	217-223	ferritin heavy chain	Equus caballus	177-188
9128147-1	1997	Myeloperoxidase (MPO), an important enzyme in the oxygen-dependent host defense system of human polymorphonuclear leukocytes, utilizes hydrogen peroxide to catalyze the production of hypochlorous acid, an oxidizing bactericidal agent.	Oxygen	50-56	myeloperoxidase	Homo sapiens	0-15
9128147-1	1997	Myeloperoxidase (MPO), an important enzyme in the oxygen-dependent host defense system of human polymorphonuclear leukocytes, utilizes hydrogen peroxide to catalyze the production of hypochlorous acid, an oxidizing bactericidal agent.	Oxygen	50-56	myeloperoxidase	Homo sapiens	17-20
9174102-4	1997	At a resting potential of -90 m V, ryanodine at very low concentrations, 10(-11) M, causes the RyR to have a low conductance state which allows calcium to leak from the terminal cisternae of the sarcoplasmic reticulum and to be recycled with ATP utilization, leading to a marked increase in oxygen consumption and aerobic metabolism.	Oxygen	291-297	ryanodine receptor 1	Homo sapiens	95-98
9135350-3	1997	cannula and breathed oxygen 5 litre min-1.	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
9120018-0	1997	Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation.	Oxygen	68-74	coagulation factor III	Mus musculus	14-27
9195048-8	1997	These results suggest that active oxygen species are involved in induction of the JE gene caused by TPA in Balb 3T3 cells, through NF kappa B activation.	Oxygen	34-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-141
9074623-1	1997	Diffusion coefficients of oxygen (DO2) and hemoglobin (DHb) were obtained from measuring the oxygen flux through thin layers of hemoglobin solutions at 20 degrees C. The liquid layers were supported by a membrane and not soaked in any filter material.	Oxygen	93-99	DNA helicase B	Homo sapiens	55-58
9128034-4	1997	After 15 minutes of high flow anesthesia, the total gas flow was reduced to 300 ml.min-1 of oxygen, 300 ml.min-1 of nitrous oxide or reduced to 400 ml.min-1 of oxygen, 200 ml.min-1 of nitrous oxide in the low flow anesthesia group.	Oxygen	92-98	CD59 molecule (CD59 blood group)	Homo sapiens	83-88
9126339-3	1997	Our reverse transcriptase-polymerase chain reaction (RT-PCR) technique revealed the expression of iNOS mRNA in Hep3B cells after incubation under hypoxic (1% O2) conditions for 6 hr.	Oxygen	158-160	nitric oxide synthase 2	Homo sapiens	98-102
9056265-13	1997	mRNA levels of glutathione reductase, measured by RT-PCR, increased in response to exposure to 100% ambient oxygen by almost twofold and administration of paraquat by greater than threefold.	Oxygen	108-114	Thioredoxin reductase-1	Drosophila melanogaster	15-36
9126290-6	1997	Flt-1, Flk-1, and ACE-containing cells were detected in 3% O2-treated explants, whereas 20% O2 explants were virtually negative.	Oxygen	59-61	angiotensin I converting enzyme	Rattus norvegicus	18-21
9135130-0	1997	Transgenic tobacco expressing a foreign calmodulin gene shows an enhanced production of active oxygen species.	Oxygen	95-101	calmodulin	Nicotiana tabacum	40-50
9135130-4	1997	Cells expressing VU-3 calmodulin exhibited a stronger active oxygen burst that occurred more rapidly than in normal control cells challenged with the same stimuli.	Oxygen	61-67	calmodulin	Nicotiana tabacum	22-32
9086279-3	1997	Rate constants for O2, CO and NO binding to recombinant Lba are identical with those of native soybean Lba.	Oxygen	19-21	leghemoglobin A	Glycine max	56-59
9086279-9	1997	The His(E7) to Phe mutation does cause a significant decrease in K(O2) for Lba, apparently due to steric hindrance of the bound ligand.	Oxygen	67-69	leghemoglobin A	Glycine max	75-78
9086279-10	1997	The rate constants for O2 dissociation from wild-type and native Lba decrease significantly with decreasing pH.	Oxygen	23-25	leghemoglobin A	Glycine max	65-68
9086279-12	1997	All of these results support the hypothesis that the high affinity of Lba for oxygen and other ligands is determined primarily by enhanced accessibility and reactivity of the heme group.	Oxygen	78-84	leghemoglobin A	Glycine max	70-73
9084498-5	1997	The experiments using some scavengers of active oxygen species revealed that tocopherol and ascorbic acid could strongly reduced LA oxidation caused by Cyt c or Mb.	Oxygen	48-54	cytochrome c, somatic	Homo sapiens	152-157
9065490-9	1997	The present data support a role for oxidative damage in the pathogenesis of AD, provide an important mechanistic link between Abeta and the generation of reactive oxygen intermediates, and identify molecular targets for therapeutic intervention in AD.	Oxygen	163-169	amyloid beta precursor protein	Homo sapiens	126-131
9209397-2	1997	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), we find that expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia) and that the cell death does not involve ROS, suggesting that Bcl-2 or Bcl-xL exerts an anti-cell death function by a mechanism other than through regulation of ROS activity.	Oxygen	80-86	BCL2 apoptosis regulator	Homo sapiens	53-58
9209397-2	1997	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), we find that expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia) and that the cell death does not involve ROS, suggesting that Bcl-2 or Bcl-xL exerts an anti-cell death function by a mechanism other than through regulation of ROS activity.	Oxygen	80-86	BCL2 apoptosis regulator	Homo sapiens	129-134
9209397-2	1997	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), we find that expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia) and that the cell death does not involve ROS, suggesting that Bcl-2 or Bcl-xL exerts an anti-cell death function by a mechanism other than through regulation of ROS activity.	Oxygen	80-86	BCL2 like 1	Homo sapiens	138-144
9209397-2	1997	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), we find that expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia) and that the cell death does not involve ROS, suggesting that Bcl-2 or Bcl-xL exerts an anti-cell death function by a mechanism other than through regulation of ROS activity.	Oxygen	80-86	BCL2 apoptosis regulator	Homo sapiens	129-134
9122249-3	1997	This activation required reactive oxygen intermediates as messengers because an antioxidant prevented A beta-induced NF-kappaB activation.	Oxygen	34-40	amyloid beta precursor protein	Homo sapiens	102-108
9122249-3	1997	This activation required reactive oxygen intermediates as messengers because an antioxidant prevented A beta-induced NF-kappaB activation.	Oxygen	34-40	nuclear factor kappa B subunit 1	Homo sapiens	117-126
9092140-1	1997	The recent observation that mutations in cytosolic CuZn-superoxide dismutase (CuZn-SOD) are associated with amyotrophic lateral sclerosis (ALS) suggests that the disease arises from a perturbation of the homeostasis of free radicals resulting in neuronal degeneration by reactive oxygen species.	Oxygen	280-286	superoxide dismutase 1	Homo sapiens	51-76
9092140-1	1997	The recent observation that mutations in cytosolic CuZn-superoxide dismutase (CuZn-SOD) are associated with amyotrophic lateral sclerosis (ALS) suggests that the disease arises from a perturbation of the homeostasis of free radicals resulting in neuronal degeneration by reactive oxygen species.	Oxygen	280-286	superoxide dismutase 1	Homo sapiens	78-86
10026014-1	1997	The effect of tumor necrosis factor alpha (TNF-alpha) on vascular resistance, nitric oxide production, and consumption of oxygen and glucose was examined in a perfused tissue-isolated tumor model in nude mice.	Oxygen	122-128	tumor necrosis factor	Mus musculus	14-41
9057632-9	1997	CD34(+)-selected PBSC rescue decreased the incidence of postreinfusion nausea, emesis, and oxygen desaturation in comparison to unselected PBSC reinfusion (P &lt; or = .005 for each).	Oxygen	91-97	CD34 molecule	Homo sapiens	0-4
10026014-1	1997	The effect of tumor necrosis factor alpha (TNF-alpha) on vascular resistance, nitric oxide production, and consumption of oxygen and glucose was examined in a perfused tissue-isolated tumor model in nude mice.	Oxygen	122-128	tumor necrosis factor	Mus musculus	43-52
9062344-9	1997	Monoclonal antibodies directed against rat CD18 and ICAM-1, as well as TMB-8, a calcium inhibitor, prevented the calcium mobilization, active oxygen production, and NF-kappaB activation in addition to the increased production of NO.	Oxygen	142-148	integrin subunit beta 2	Rattus norvegicus	43-47
9118935-6	1997	Mean oxygen consumption standing still at the start of the trial was 0.421 min-1 (SD = 0.101 min-1, max.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	75-80
9118935-6	1997	Mean oxygen consumption standing still at the start of the trial was 0.421 min-1 (SD = 0.101 min-1, max.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9118935-9	1997	During exercise, the mean oxygen consumption rose to 2.711 min-1 (SD = 0.641 min-1, max = 4.051 min-1) and mean ventilation reached 46.341 min-1 (SD = 15.831 min-1, max = 87.361 min-1) during the fifth minute of exercise.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9083891-0	1997	Modification of in vivo and in vitro TNF-alpha, IL-1, and IL-6 secretion by circulating monocytes during hyperbaric oxygen treatment in patients with perianal Crohn"s disease.	Oxygen	116-122	interleukin 6	Homo sapiens	58-62
9110146-2	1997	TNF-mediated activation of NF-kappa B is known to involve the intracellular formation of reactive oxygen intermediates (ROIs).	Oxygen	98-104	tumor necrosis factor	Homo sapiens	0-3
9110146-2	1997	TNF-mediated activation of NF-kappa B is known to involve the intracellular formation of reactive oxygen intermediates (ROIs).	Oxygen	98-104	nuclear factor kappa B subunit 1	Homo sapiens	27-37
9136522-7	1997	P70 and P70/L showed the better correlations than the other parameters, including significant correlations with vital capacity, FEV1.0, peak flow rate, RV/ TLC, diffusing capacity and arterial oxygen partial pressure.	Oxygen	193-199	ubiquitin associated and SH3 domain containing B	Homo sapiens	8-13
9128901-1	1997	O2 uptake in the lungs, and therefore arterial oxygenation, is favored by a low Hb-P50 but this inhibits tissue O2 extraction, raising the question of optimal P50 during maximal exercise when VO2 is limited by O2 supply.	Oxygen	0-2	nuclear factor kappa B subunit 1	Homo sapiens	83-86
9151285-1	1997	The enzyme Cu-Zn-SOD is a metalloenzyme that catalyzes the dismutation of the superoxide radical into hydrogen peroxide and molecular oxygen, being a defense system against free radical formation.	Oxygen	134-140	superoxide dismutase 1	Rattus norvegicus	11-20
9073571-3	1997	Oxygen levels are sensed by changes in heme biosynthesis, which controls the transcription of the ROX1 gene, encoding a protein that binds to the regulatory region of each hypoxic gene to repress transcription.	Oxygen	0-6	Rox1p	Saccharomyces cerevisiae S288C	98-102
9073573-0	1997	Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates.	Oxygen	72-78	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-47
9050990-8	1997	Identification of a peroxidase as a KGF-regulated gene suggests that prevention from oxygen toxicity is a novel and specific mechanism of KGF action.	Oxygen	85-91	fibroblast growth factor 7	Homo sapiens	36-39
9047321-11	1997	To explain the mode via which the phenolic hydroxyl facilitates ortho hydroxylation, a mechanism in which the phenolic moiety attacks the iron-oxo double bond of CYP3A4, resulting in oxygen transfer to the ortho position, is proposed.	Oxygen	183-189	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-168
9038179-6	1997	Equilibrium oxygen binding experiments reveal an increase in oxygen affinity and decrease in cooperativity as the concentration is lowered (in the muM range).	Oxygen	12-18	latexin	Homo sapiens	147-150
9050990-8	1997	Identification of a peroxidase as a KGF-regulated gene suggests that prevention from oxygen toxicity is a novel and specific mechanism of KGF action.	Oxygen	85-91	fibroblast growth factor 7	Homo sapiens	138-141
16535510-5	1997	When the pO(inf2) was raised, the rates of both nitrification and denitrification increased instantaneously, indicating that ammonia oxidation was limited by oxygen.	Oxygen	158-164	inverted formin 2	Homo sapiens	9-16
9028967-5	1997	Antisense oligonucleotide for hGATA-2 transcription factor significantly increased the Epo protein in Hep3B cells under 1% O2 for 24 hours incubation.	Oxygen	123-125	erythropoietin	Homo sapiens	87-90
9049601-5	1997	The vasopressor activity of angiotensin II on coronary perfusion pressure was significantly changed, as compared to that in the control preparation: these alterations, well correlated to the time of hyperbaric oxygen exposure, seem to suggest impairment of the vascular endothelium-dependent relaxant function.	Oxygen	210-216	angiotensinogen	Rattus norvegicus	28-42
9171924-3	1997	Available data on consequences of Cu,Zn-SOD gene transfection in cell resistance to oxygen toxicity are reviewed.	Oxygen	84-90	superoxide dismutase 1	Homo sapiens	40-43
9089389-2	1997	Epo production is reduced in normoxia and activated in hypoxia to control the oxygen supply through erythropoiesis.	Oxygen	78-84	erythropoietin	Homo sapiens	0-3
9008240-1	1997	Glutathione S-transferases (GSTs) play a primary role in cellular defense against electrophilic chemical species and radical oxygen species.	Oxygen	125-131	glutathione S-transferase mu 1	Homo sapiens	28-32
9008235-6	1997	We demonstrate here that minoxidil is a potent activator of purified PGHS-1 (AC50 = 80 microM), as assayed by oxygen consumption and PGE2 production.	Oxygen	110-116	prostaglandin-endoperoxide synthase 1	Homo sapiens	69-75
9027715-6	1997	This suggests that EPO does not cross the intact blood-brain-barrier, implying that EPO is produced in the brain itself, most probably by astrocytes in an oxygen-dependent manner.	Oxygen	155-161	erythropoietin	Homo sapiens	84-87
9027719-3	1997	Hypoxia (8% O2) for six hours caused a 55-fold/1.6-fold increase of renal erythropoietin/endothelin-1 gene expression, whereas endothelin-3, PDGF-A, PDGF-B, and VEGF gene expression was unchanged.	Oxygen	12-14	endothelin 1	Rattus norvegicus	89-101
9052449-5	1997	Of 17 patients with oxygen delivery levels lower than 445 ml min-1 m-2 at 6 h, eight died in hospital.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
9027728-8	1997	On the other hand, NADPH and pyrogallol which stimulate the production of O2- inhibited Epo production.	Oxygen	74-76	erythropoietin	Homo sapiens	88-91
9027736-0	1997	Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors.	Oxygen	57-63	erythropoietin	Homo sapiens	0-14
9027736-6	1997	Under hyperbaric oxygen, cobalt induction of erythropoietin mRNA was modestly suppressed while nickel induction was markedly enhanced.	Oxygen	17-23	erythropoietin	Homo sapiens	45-59
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-40
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
9027728-1	1997	We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2.	Oxygen	86-92	erythropoietin	Homo sapiens	127-141
9027728-1	1997	We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2.	Oxygen	86-92	erythropoietin	Homo sapiens	143-146
9027728-1	1997	We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2.	Oxygen	30-32	erythropoietin	Homo sapiens	127-141
9027728-1	1997	We have recently proposed a H2O2-generating b-type cytochrome as part of the cellular oxygen sensor that controls O2-dependent erythropoietin (Epo) production in the human hepatocellular carcinoma cell line HepG2.	Oxygen	30-32	erythropoietin	Homo sapiens	143-146
9027743-1	1997	Synthesis of erythropoietin (Epo), the glycoprotein hormone that regulates red blood cell formation, is induced in response to low oxygen stress (hypoxia), and is regulated at both transcriptional and post-transcriptional levels.	Oxygen	131-137	erythropoietin	Homo sapiens	13-27
9027743-1	1997	Synthesis of erythropoietin (Epo), the glycoprotein hormone that regulates red blood cell formation, is induced in response to low oxygen stress (hypoxia), and is regulated at both transcriptional and post-transcriptional levels.	Oxygen	131-137	erythropoietin	Homo sapiens	29-32
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-40
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-40
9027737-8	1997	In HeLa cells, the levels of HIF-1 alpha and HIF-1 beta protein and HIF-1 DNA-binding activity increased exponentially as cellular oxygen tension decreased, with maximum values at 0.5% oxygen and half-maximal values at 1.5 to 2% oxygen.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
9027719-1	1997	There is accumulating evidence from in vitro studies suggesting that the genes of endothelin-1, PDGF, and VEGF are, like the erythropoietin gene, regulated by oxygen tension and by divalent cations.	Oxygen	159-165	endothelin 1	Rattus norvegicus	82-94
9027739-1	1997	The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF).	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
9027739-1	1997	The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF).	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
9027739-1	1997	The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF).	Oxygen	71-77	erythropoietin	Homo sapiens	102-116
9034127-3	1997	Superoxide dismutase (SOD), by rapidly removing O2-, reduces the tissue concentration of O2- and prevents the production of HO.	Oxygen	48-50	superoxide dismutase 1	Homo sapiens	0-20
9027739-1	1997	The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF).	Oxygen	71-77	vascular endothelial growth factor A	Homo sapiens	121-155
9027739-1	1997	The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF).	Oxygen	71-77	vascular endothelial growth factor A	Homo sapiens	157-161
9027740-1	1997	The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
9027740-1	1997	The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression.	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
9027740-1	1997	The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression.	Oxygen	179-185	erythropoietin	Homo sapiens	196-210
9027740-2	1997	In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detectable in nuclear extracts of cells cultivated in a low oxygen atmosphere.	Oxygen	144-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
9001239-1	1997	The erythropoietin (EPO) gene is one of the best examples of a mammalian gene controlled by oxygen tension.	Oxygen	92-98	erythropoietin	Homo sapiens	4-18
9001239-1	1997	The erythropoietin (EPO) gene is one of the best examples of a mammalian gene controlled by oxygen tension.	Oxygen	92-98	erythropoietin	Homo sapiens	20-23
9051826-0	1997	Effect of an endothelin-1 antagonist, BQ-485, on cerebral oxygen metabolism after complete global cerebral ischemia in dogs.	Oxygen	58-64	endothelin 1	Canis lupus familiaris	13-25
9034127-3	1997	Superoxide dismutase (SOD), by rapidly removing O2-, reduces the tissue concentration of O2- and prevents the production of HO.	Oxygen	48-50	superoxide dismutase 1	Homo sapiens	22-25
9090755-1	1997	In this study, we examined how disrupted hepatic active oxygen metabolism at a progressed stage of carbon tetrachloride (CCl4)-induced acute liver injury is attenuated with the recovery of the injury in fed rats.	Oxygen	56-62	C-C motif chemokine ligand 4	Rattus norvegicus	121-125
9090755-9	1997	These results indicate that in rats intoxicated once with CCl4, disrupted hepatic active oxygen metabolism at a progressed stage of liver injury is attenuated with the recovery of the injury mainly through the improvement of hepatic active oxygen metabolism mediated by the glutathione redox cycle and ascorbic acid.	Oxygen	89-95	C-C motif chemokine ligand 4	Rattus norvegicus	58-62
9090755-9	1997	These results indicate that in rats intoxicated once with CCl4, disrupted hepatic active oxygen metabolism at a progressed stage of liver injury is attenuated with the recovery of the injury mainly through the improvement of hepatic active oxygen metabolism mediated by the glutathione redox cycle and ascorbic acid.	Oxygen	240-246	C-C motif chemokine ligand 4	Rattus norvegicus	58-62
9034127-3	1997	Superoxide dismutase (SOD), by rapidly removing O2-, reduces the tissue concentration of O2- and prevents the production of HO.	Oxygen	89-91	superoxide dismutase 1	Homo sapiens	0-20
9034127-3	1997	Superoxide dismutase (SOD), by rapidly removing O2-, reduces the tissue concentration of O2- and prevents the production of HO.	Oxygen	89-91	superoxide dismutase 1	Homo sapiens	22-25
9034127-6	1997	Considerable supportive, though not all conclusive, evidence suggests that all three forms of SOD are essential for the pulmonary defense against oxygen toxicity, and that enhancement of pulmonary SOD has the potential of protecting against oxygen toxicity.	Oxygen	146-152	superoxide dismutase 1	Homo sapiens	94-97
9034127-6	1997	Considerable supportive, though not all conclusive, evidence suggests that all three forms of SOD are essential for the pulmonary defense against oxygen toxicity, and that enhancement of pulmonary SOD has the potential of protecting against oxygen toxicity.	Oxygen	241-247	superoxide dismutase 1	Homo sapiens	197-200
10074304-3	1997	AT II secretion increased significantly when PAECs were incubated under 2.5% O2 hypoxic condition for 1.5 h (P &lt; 0.01 vs control).	Oxygen	77-79	angiotensinogen	Homo sapiens	0-5
9037228-12	1997	Vasopressin receptor blockade also maintained oxygen extraction ratio and ketone body availability in the mesenteric circulation.	Oxygen	46-52	arginine vasopressin	Rattus norvegicus	0-11
9048485-3	1997	Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation.	Oxygen	79-85	nuclear factor kappa B subunit 1	Homo sapiens	138-148
9002952-5	1997	Measurements of src kinase activity in cells exposed to varying severities of hypoxia showed activation by severe hypoxia (0.1% oxygen or catalyst induced anoxia), but not 1% oxygen.	Oxygen	128-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-19
17029821-6	1997	The result indicated that considering the evaporation of O2 was necessary in order to interpret the oscillatory reactions of catalase in addition to the slow entry of substrate caused by deviation from the equilibrium concentration.	Oxygen	57-59	catalase	Homo sapiens	125-133
9037485-5	1997	The oxygen concentration regulates EPO production; hypoxia stimulates EPO production in astrocytes.	Oxygen	4-10	erythropoietin	Homo sapiens	35-38
9044187-0	1997	Free-flap monitoring with tissue-oxygen measurement.	Oxygen	33-39	arachidonate 5-lipoxygenase activating protein	Homo sapiens	5-9
9044187-1	1997	Flap monitoring by oxygen measurement with a microcatheter pO2 probe was carried out in 17 free flaps.	Oxygen	19-25	arachidonate 5-lipoxygenase activating protein	Homo sapiens	0-4
9002952-6	1997	This contrasted with the marked induction of HIF-1 by exposure to 1% oxygen.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-50
8994409-0	1997	Modulation of myocardial oxygen consumption through ACE inhibitors.	Oxygen	25-31	angiotensin I converting enzyme	Homo sapiens	52-55
9020887-9	1997	In the presence of oxygen, ABAH and hydrogen peroxide initially converted myeloperoxidase into compound III, which subsequently lost haem absorbance.	Oxygen	19-25	myeloperoxidase	Homo sapiens	74-89
9020887-10	1997	In the absence of oxygen, the enzyme was converted into ferrous myeloperoxidase and its haem groups were rapidly destroyed.	Oxygen	18-24	myeloperoxidase	Homo sapiens	64-79
9020887-12	1997	Ferrous myeloperoxidase reacts either with oxygen to allow enzyme turnover, or with hydrogen peroxide to give irreversible inactivation.	Oxygen	43-49	myeloperoxidase	Homo sapiens	8-23
8994434-0	1997	ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption.	Oxygen	72-78	angiotensin I converting enzyme	Homo sapiens	0-3
9016819-3	1997	CYP2E1 is also very effective in generating reactive oxygen intermediates such as superoxide radical and H2O2, oxidizing ethanol to the 1-hydroxyethyl radical, and has a high NADPH oxidase activity.	Oxygen	53-59	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
9016819-13	1997	NO appears to compete with O2 and CO for binding to CYP2E1 as incubation with gaseous NO, or NO donors inhibited formation of the characteristic CO binding spectrum of P450.	Oxygen	27-29	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	52-58
8994434-2	1997	Whether ACE inhibitors also affect myocardial O2 consumption has not been established.	Oxygen	46-48	angiotensin I converting enzyme	Homo sapiens	8-11
9408378-8	1997	A close correlation between pCO2 in brain tissue and sagittal sinus and the increase of the inspired oxygen was seen: CC ptiCO2 to arterial oxygen pressure (paO2) - r(mean) = 0.67, CC pcvCO2 to paO2 - r(mean) = 0.88.	Oxygen	101-107	PCO2	Sus scrofa	28-32
8994434-8	1997	CONCLUSIONS: Our data indicate that stimulation of local kinin formation by use of a precursor for kinin formation or inhibition of kinin degradation by use of ACE inhibitors increases NO formation and is important in the control of cardiac O2 consumption.	Oxygen	241-243	angiotensin I converting enzyme	Homo sapiens	160-163
8994434-9	1997	Vasodilation and control of myocardial O2 consumption by NO may contribute importantly to the therapeutic actions of ACE inhibitors in cardiac disease states.	Oxygen	39-41	angiotensin I converting enzyme	Homo sapiens	117-120
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
9020025-4	1997	By contrast, pretreatment with TNF (2000 ng/ml) for 24 h followed by exposure to H2O2 (1000 microM) reduced the reactive oxygen-induced cytotoxicity.	Oxygen	121-127	tumor necrosis factor	Rattus norvegicus	31-34
9408378-8	1997	A close correlation between pCO2 in brain tissue and sagittal sinus and the increase of the inspired oxygen was seen: CC ptiCO2 to arterial oxygen pressure (paO2) - r(mean) = 0.67, CC pcvCO2 to paO2 - r(mean) = 0.88.	Oxygen	140-146	PCO2	Sus scrofa	28-32
9500074-0	1997	Peripheral oxygen supply in children during therapy with human growth hormone (hGH).	Oxygen	11-17	growth hormone 1	Homo sapiens	63-77
9083624-4	1997	The suppression of Cys-induced metHb formation by the addition of superoxide dismutase (SOD) and catalase indicated that Cys was easily oxidized by oxygen and simultaneously generated a large amount of active oxygens.	Oxygen	148-154	catalase	Homo sapiens	97-105
15374139-3	1997	Although this system is an important component of the defenses that protect living organisms against toxic chemicals, some reactions catalyzed by the cytochrome P-450 system result in the formation of products that are highly reactive as well as active oxygen species.	Oxygen	253-259	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-166
9083624-4	1997	The suppression of Cys-induced metHb formation by the addition of superoxide dismutase (SOD) and catalase indicated that Cys was easily oxidized by oxygen and simultaneously generated a large amount of active oxygens.	Oxygen	209-216	catalase	Homo sapiens	97-105
22358524-5	1997	We also present new data which demonstrates that bcl-2 can protect cells from apoptosis induced by oxygen deprivation, a finding which has important implications for large scale and intensive cultivation of cells.	Oxygen	99-105	BCL2 apoptosis regulator	Homo sapiens	49-54
9363841-4	1997	It has been reported by (Tindberg and Ingelman-Sundberg 1989) that hyperoxic exposure (95% O2) induced a several-fold increase of CYP2E1 protein in both the liver and lung of exposed rats without affecting the level of CYP2E1 mRNA.	Oxygen	91-93	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	130-136
9363841-4	1997	It has been reported by (Tindberg and Ingelman-Sundberg 1989) that hyperoxic exposure (95% O2) induced a several-fold increase of CYP2E1 protein in both the liver and lung of exposed rats without affecting the level of CYP2E1 mRNA.	Oxygen	91-93	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	219-225
9056074-11	1997	in the presence of O2 formed nitrosylated cysteine followed by the transnitrosation of regulatory thiols on the RyR to activate the channel.	Oxygen	19-21	ryanodine receptor 2	Homo sapiens	112-115
9038595-13	1997	Predicted maximum oxygen uptake increased in walkers by 2.1 (0.9) ml min-1 kg-1 (P = 0.02).	Oxygen	18-24	CD59 molecule (CD59 blood group)	Homo sapiens	69-79
8995987-11	1997	In patients, releases of both beta-endorphin and norepinephrine during exercise were related to peak oxygen consumption and duration of exercise, but not to resting left ventricular ejection fraction.	Oxygen	101-107	proopiomelanocortin	Homo sapiens	30-44
8989188-14	1997	CONCLUSIONS: Priming with TNF-alpha counteracts the inhibitory effect by certain drugs for oxygen radical formation by FMLP-stimulated neutrophils.	Oxygen	91-97	tumor necrosis factor	Homo sapiens	26-35
8989188-15	1997	Thus, TNF-alpha plus FMLP mediate additive effects in stimulating oxygen radical formation in neutrophils.	Oxygen	66-72	tumor necrosis factor	Homo sapiens	6-15
8981031-2	1997	With the PMN system, the luminescence was enhanced by addition of tyrosine, its analogues, or albumin, but was inhibited by hydroxyurea, superoxide dismutase (SOD), or NaN3 (an inhibitor of MPO), indicating participation of tyrosine phenoxyl radicals, O2.- and MPO in the luminescence.	Oxygen	252-254	superoxide dismutase 1	Homo sapiens	137-157
9273993-0	1997	The role of entropy in the discrimination between CO and O2 in myoglobin.	Oxygen	57-59	myoglobin	Equus caballus	63-72
8981031-2	1997	With the PMN system, the luminescence was enhanced by addition of tyrosine, its analogues, or albumin, but was inhibited by hydroxyurea, superoxide dismutase (SOD), or NaN3 (an inhibitor of MPO), indicating participation of tyrosine phenoxyl radicals, O2.- and MPO in the luminescence.	Oxygen	252-254	superoxide dismutase 1	Homo sapiens	159-162
8981036-4	1997	The activity of gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting GSH synthesizing enzyme increased in 20% O2-exposed embryos (24.83 +/- 0.71 vs 21.00 +/- 0.94 microunits/mg protein).	Oxygen	122-124	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	16-49
8981036-4	1997	The activity of gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting GSH synthesizing enzyme increased in 20% O2-exposed embryos (24.83 +/- 0.71 vs 21.00 +/- 0.94 microunits/mg protein).	Oxygen	122-124	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	51-60
9034244-8	1997	The inverse relationship between LGO and SOD is also observed in rats during postnatal development, that is when the new born rats are exposed to high concentration of atmospheric oxygen.	Oxygen	180-186	superoxide dismutase 1	Homo sapiens	41-44
9868059-6	1997	The release of t-PA is decreased in smokers, that might be resulted from the increases of oxygen free radicals.	Oxygen	90-96	plasminogen activator, tissue type	Homo sapiens	15-19
9336736-1	1997	Hill"s equation relating oxygen tension, saturation and P50 is used as the basis for a simple method to calculate P50 from a single blood sample.	Oxygen	25-31	nuclear factor kappa B subunit 1	Homo sapiens	114-117
9336736-1	1997	Hill"s equation relating oxygen tension, saturation and P50 is used as the basis for a simple method to calculate P50 from a single blood sample.	Oxygen	25-31	nuclear factor kappa B subunit 1	Homo sapiens	56-59
9352384-1	1997	Uranium salts, such as uranyl nitrate, induce severe renal dysfunction and tubular necrosis and a significant impairment of both oxygen dependent erythropoietin production and response to recombinant human erythropoietin.	Oxygen	129-135	erythropoietin	Homo sapiens	146-160
9466185-5	1997	When sperm preparations which produced ROS were incubated under 95% O2 there was a rapid 40% decrease in the number of sperm that could be stimulated to acrosome react although the acrosome reaction was unaffected by incubation under 95% N2 for up to 6 h. The harmful effect of oxygen was not seen in preparations that produced no ROS and could be prevented by removing leukocytes from the suspension or by adding superoxide dismutase and catalase.	Oxygen	68-70	catalase	Homo sapiens	439-447
9029202-0	1997	Myoglobin oxygen dissociation by multiwavelength spectroscopy.	Oxygen	10-16	myoglobin	Equus caballus	0-9
9029202-1	1997	Multiwavelength optical spectroscopy was used to determine the oxygen-binding characteristics for equine myoglobin.	Oxygen	63-69	myoglobin	Equus caballus	105-114
9029202-6	1997	The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)].	Oxygen	5-7	myoglobin	Equus caballus	17-26
9272379-6	1997	These results indicate that the VEGF induction in BMEC can proceed through PKC-dependent and -independent pathways (like those acting via the putative oxygen sensor).	Oxygen	151-157	vascular endothelial growth factor A	Homo sapiens	32-36
9029202-6	1997	The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)].	Oxygen	5-7	myoglobin	Equus caballus	122-131
9011596-1	1997	We evaluated in a double-blind randomized study the effect of epoetin beta (recombinant human erythropoietin) therapy on oxygen status in patients undergoing cardiac surgery who were contraindicated for autologous blood donation.	Oxygen	121-127	erythropoietin	Homo sapiens	94-108
9276001-7	1997	The released O2- was measured by the superoxide dismutase inhibitable reduction of cytochrome C.	Oxygen	13-15	cytochrome c, somatic	Homo sapiens	83-95
9490335-2	1997	It was found that use of ozone-oxygen mixtures leads to hypocoagulatory changes (diminution of platelet aggregation, lowering of fibrinogen concentration, prolongation of activated partial thromboplastin time, enhanced fibrinolytic activity) which contribute to clinical response.	Oxygen	31-37	fibrinogen beta chain	Homo sapiens	129-139
8996233-3	1997	We, therefore, investigated the role of oxygen-derived free radicals generated from Fenton"s reagent (3 x 10(-4) M H2O2 plus 2 x 10(-4) M FeSO4) on CGRP-mediated neurogenic relaxation of canine lingual artery ring preparations.	Oxygen	40-46	calcitonin related polypeptide alpha	Homo sapiens	148-152
9003388-2	1996	The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B).	Oxygen	129-135	nuclear factor kappa B subunit 1	Homo sapiens	195-205
9194682-3	1997	These results are interpreted in line with previous findings of higher brain ferritin and lower brain transferrin levels in DAT and are a circumstantial support for the oxygen radical hypothesis of degenerative brain disease.	Oxygen	169-175	transferrin	Homo sapiens	102-113
8955077-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other proteins that are important for maintaining oxygen homeostasis.	Oxygen	307-313	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8955077-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other proteins that are important for maintaining oxygen homeostasis.	Oxygen	307-313	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
8955077-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other proteins that are important for maintaining oxygen homeostasis.	Oxygen	307-313	erythropoietin	Homo sapiens	201-215
8955077-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other proteins that are important for maintaining oxygen homeostasis.	Oxygen	307-313	vascular endothelial growth factor A	Homo sapiens	217-251
8955081-2	1996	Reaction of H2O2 with ferric leghemoglobin (metLb, the monomeric, oxygen-carrying, heme protein from root nodules of nitrogen-fixing plants) has been previously shown to generate an iron(IV)-oxo (ferryl) species and at least one protein radical.	Oxygen	66-72	leghemoglobin A	Glycine max	29-42
9201685-7	1997	The data and parameters presented are shown to serve as a basis for more extensive investigations of root nodules (e.g., the oxygen diffusion barrier or the mechanisms driving the regulation of the oxygen concentration in the infected zone by leghemoglobin) by NMR microimaging.	Oxygen	198-204	leghemoglobin A	Glycine max	243-256
9413891-3	1997	Superoxide dismutase (SOD), a primary antioxidant, accelerates the dismutation of the toxic superoxide radical produced during the oxidative energy processes into the less harmful molecules, hydrogen peroxide and molecular oxygen.	Oxygen	223-229	superoxide dismutase 1	Homo sapiens	0-20
9413891-3	1997	Superoxide dismutase (SOD), a primary antioxidant, accelerates the dismutation of the toxic superoxide radical produced during the oxidative energy processes into the less harmful molecules, hydrogen peroxide and molecular oxygen.	Oxygen	223-229	superoxide dismutase 1	Homo sapiens	22-25
8955187-9	1996	These results suggest that CpG DNA-induced IL-6 production is mediated through a reactive oxygen intermediate-dependent pathway.	Oxygen	90-96	interleukin 6	Mus musculus	43-47
8997205-1	1996	We test the hypothesis that myoglobin is important for O2 supply near the oxidative capacity of muscle.	Oxygen	55-57	myoglobin	Equus caballus	28-37
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Oxygen	243-251	nitric oxide synthase 2	Homo sapiens	4-25
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Oxygen	243-251	heat shock protein family A (Hsp70) member 5	Homo sapiens	108-111
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Oxygen	253-255	nitric oxide synthase 2	Homo sapiens	4-25
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Oxygen	253-255	heat shock protein family A (Hsp70) member 5	Homo sapiens	108-111
8943284-5	1996	Hypoxia-induced HIF-1 binding as well as the HIF-1alpha protein were rapidly and drastically decreased in vivo following an abrupt increase to normal oxygen tension.	Oxygen	150-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
8997205-5	1996	The myoglobin content of these fibers is significantly correlated with this O2 diffusion limitation and provides sufficient additional O2 flux to meet muscle O2 demand.	Oxygen	76-78	myoglobin	Equus caballus	4-13
8997205-5	1996	The myoglobin content of these fibers is significantly correlated with this O2 diffusion limitation and provides sufficient additional O2 flux to meet muscle O2 demand.	Oxygen	135-137	myoglobin	Equus caballus	4-13
8997205-5	1996	The myoglobin content of these fibers is significantly correlated with this O2 diffusion limitation and provides sufficient additional O2 flux to meet muscle O2 demand.	Oxygen	135-137	myoglobin	Equus caballus	4-13
8997205-7	1996	Thus myoglobin is critical to O2 supply at fluxes near the maximum and prevents anoxia by maintaining PO2 above levels needed to support mitochondrial function.	Oxygen	30-32	myoglobin	Equus caballus	5-14
8997208-7	1996	Oxygen diffusion to mitochondria contributed maximally 30% to the regulation of P50 in coupled cells, as deduced from the shallow slope of the flux dependence of P50 in uncoupled-inhibited cells compared with the slope in coupled cells.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	80-83
9038447-3	1996	The generator was found to supply a mean (SD) flow of oxygen of 3.6 (0.01) l.min-1 for 12.5 (range 12.4-12.6)min.	Oxygen	54-60	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
9038447-4	1996	The mean (SD) total volume of oxygen produced was 47(0.17) l. The supplied oxygen mask was a variable performance type with the problems and limitations inherent in this design; an oxygen flow of 8 l.min-1 is required to provide 40% oxygen and most of the oxygen is wasted and not available to the patient.	Oxygen	30-36	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
9038447-4	1996	The mean (SD) total volume of oxygen produced was 47(0.17) l. The supplied oxygen mask was a variable performance type with the problems and limitations inherent in this design; an oxygen flow of 8 l.min-1 is required to provide 40% oxygen and most of the oxygen is wasted and not available to the patient.	Oxygen	75-81	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
9038447-4	1996	The mean (SD) total volume of oxygen produced was 47(0.17) l. The supplied oxygen mask was a variable performance type with the problems and limitations inherent in this design; an oxygen flow of 8 l.min-1 is required to provide 40% oxygen and most of the oxygen is wasted and not available to the patient.	Oxygen	75-81	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
9038447-4	1996	The mean (SD) total volume of oxygen produced was 47(0.17) l. The supplied oxygen mask was a variable performance type with the problems and limitations inherent in this design; an oxygen flow of 8 l.min-1 is required to provide 40% oxygen and most of the oxygen is wasted and not available to the patient.	Oxygen	75-81	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
9038447-4	1996	The mean (SD) total volume of oxygen produced was 47(0.17) l. The supplied oxygen mask was a variable performance type with the problems and limitations inherent in this design; an oxygen flow of 8 l.min-1 is required to provide 40% oxygen and most of the oxygen is wasted and not available to the patient.	Oxygen	75-81	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
9008404-1	1996	The electrochemical determination of zinc arising from zinc-insulin complexes was investigated and it was demonstrated that zinc in zinc-insulin solution can be measured in the presence of dissolved oxygen by square-wave anodic stripping voltammetry (SWASV) at mercury thin-film electrodes on glassy carbon disc minielectrode and cylindrical carbon fibre microelectrode substrates.	Oxygen	199-205	insulin	Homo sapiens	60-67
9008404-1	1996	The electrochemical determination of zinc arising from zinc-insulin complexes was investigated and it was demonstrated that zinc in zinc-insulin solution can be measured in the presence of dissolved oxygen by square-wave anodic stripping voltammetry (SWASV) at mercury thin-film electrodes on glassy carbon disc minielectrode and cylindrical carbon fibre microelectrode substrates.	Oxygen	199-205	insulin	Homo sapiens	137-144
8997208-7	1996	Oxygen diffusion to mitochondria contributed maximally 30% to the regulation of P50 in coupled cells, as deduced from the shallow slope of the flux dependence of P50 in uncoupled-inhibited cells compared with the slope in coupled cells.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	162-165
8973567-6	1996	PrP-(106-126), but not the other peptides, increased membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and O2-.	Oxygen	161-163	prion protein	Homo sapiens	0-3
8973567-10	1996	PrP-(106-126) stimulated O2-.	Oxygen	25-27	prion protein	Homo sapiens	0-3
9222437-5	1996	The key to successful transitions in several systems is the induction, during the oxygen-limited state, of elevated activities of antioxidant and associated enzymes, such as catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase, so that damage during the reintroduction of oxygen (such as lipid peroxidation) is minimized.	Oxygen	305-311	catalase	Homo sapiens	174-182
9222437-5	1996	The key to successful transitions in several systems is the induction, during the oxygen-limited state, of elevated activities of antioxidant and associated enzymes, such as catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase, so that damage during the reintroduction of oxygen (such as lipid peroxidation) is minimized.	Oxygen	82-88	catalase	Homo sapiens	174-182
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	Oxygen	4-10	interleukin-2	Ovis aries	81-85
9003470-2	1996	The oxygen-free-radical scavenger dimethylthiourea (DMTU) was shown to attenuate IL-2-induced vascular leak syndrome in sheep receiving a single IL-2 injection.	Oxygen	4-10	interleukin-2	Ovis aries	145-149
8951422-5	1996	In contrast, 3-morpholinosydnonimine (SIN-1), a compound that rapidly generates peroxynitrite (ONOO-) from the released NO and O2-, slightly stimulated the PMA-induced respiratory burst.	Oxygen	127-129	MAPK associated protein 1	Homo sapiens	38-43
8969127-2	1996	Before basic training the mean maximal oxygen uptake predicted from cycle ergometry (pred VO2max) for Adult Artillery Recruits was 56.1 ml (kg min)-1.	Oxygen	39-45	CD59 molecule (CD59 blood group)	Homo sapiens	143-149
9021387-0	1996	Oxygen promotes contraction by endothelin-1 in human umbilical artery.	Oxygen	0-6	endothelin 1	Homo sapiens	31-43
9021387-1	1996	The influence of oxygen on the contractile response to endothelin-1 in the human umbilical artery was investigated in vitro.	Oxygen	17-23	endothelin 1	Homo sapiens	55-67
9021387-3	1996	Endothelin-1 induced a concentration-dependent contraction which was significantly larger at 45 kPa O2 compared with the contractile response at 12 kPa O2.	Oxygen	100-102	endothelin 1	Homo sapiens	0-12
9021387-3	1996	Endothelin-1 induced a concentration-dependent contraction which was significantly larger at 45 kPa O2 compared with the contractile response at 12 kPa O2.	Oxygen	152-154	endothelin 1	Homo sapiens	0-12
8990625-2	1996	In this study, the adhesion and O2- production of PMN treated with LPS and serum, were markedly enhanced on the EC monolayer by treatment with TNF-alpha or LPS.	Oxygen	32-34	tumor necrosis factor	Homo sapiens	143-152
8986663-2	1996	Multivariate regression analysis revealed that the subjects who had had a Van Nes procedure had a mean oxygen cost (energy per unit of body mass expended per distance walked) that was 0.12 milliliter per kilogram of body mass per meter lower than that of the subjects who had had a Syme amputation (p = 0.001).	Oxygen	103-109	nestin	Homo sapiens	78-81
19245448-7	1996	Considering the involvement of catalase in skin defence against oxygen-derived free radicals generated, its increased activity may explain the beneficial role of Vichy water observed in various dermatoses.	Oxygen	64-70	catalase	Homo sapiens	31-39
8986999-6	1996	The authors conclude that infants with ALTE associated with obstructive apnea and O2 shunting require glossopexy to reduce the risk of sudden death.	Oxygen	82-84	zinc finger BED-type containing 1	Homo sapiens	39-43
8918370-1	1996	An NADPH-oxidase complex containing at least two protein components (gp91-phox and p22-phox) and a unique low redox potential (-245 mV) cytochrome b-245 is the source of superoxide generated for bacterial killing in neutrophils and has been suggested as the oxygen sensor in the carotid body.	Oxygen	258-264	cytochrome b-245 alpha chain	Rattus norvegicus	83-91
9015746-4	1996	NPH4 may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases.	Oxygen	78-84	neurexophilin 4	Homo sapiens	0-4
8916898-7	1996	Assuming the carbon monoxide complex as a model for the dioxygen complex, the more loosened binding of (1S)-camphor, therefore the increased water accessibility, and the weaker contact of the iron ligand to the I-helix might explain the higher amount of uncoupling of the cytochrome P-450 reaction cycle compared to that when (1R)-camphor is used as substrate.	Oxygen	56-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	272-288
8937726-4	1996	[125I]-[Sar1,Ile2]AII binding capacity was increased in lung membranes from rats exposed to hypoxia (10% fractional inspired O2) for 7 days compared to normal rats (Bmax 108 +/- 12 vs 77 +/- 3 fmol mg-1 protein; P &lt; 0.05), with no significant change in dissociation constant.	Oxygen	125-127	angiotensinogen	Rattus norvegicus	18-21
8941519-2	1996	Although both Dan+ and Dan- subjects achieved lower O2 consumption and CO2 production (VCO2) than control subjects at peak of exercise, they attained similar values of either minute ventilation (VE) or adjusted ventilation (VE/maximal voluntary ventilation).	Oxygen	52-54	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
9024991-3	1996	The effect of TNF-alpha on the oxygen metabolism of neutrophils was inhibited when cells were treated with PTX.	Oxygen	31-37	tumor necrosis factor	Homo sapiens	14-23
8958673-11	1996	Stimulation with IFN-gamma or TNF-alpha and subsequent phagocytosis of M. tuberculosis or M. intracellulare increased O2- production, which was assayed by the method of cytochrome C reduction by murine peritoneal macrophages.	Oxygen	118-120	interferon gamma	Mus musculus	17-26
8958673-11	1996	Stimulation with IFN-gamma or TNF-alpha and subsequent phagocytosis of M. tuberculosis or M. intracellulare increased O2- production, which was assayed by the method of cytochrome C reduction by murine peritoneal macrophages.	Oxygen	118-120	tumor necrosis factor	Mus musculus	30-39
8824225-3	1996	The oxygen equilibrium curves for purified (&gt;80%) Hb Bruxelles show little cooperativity and a P50 (without 2,3-diphosphoglycerate) about twice that of Hb A.	Oxygen	4-10	nuclear factor kappa B subunit 1	Homo sapiens	98-101
8980503-1	1996	The intrinsic chlorophyll-protein CP 47 is a component of photosystem II which functions in both light-harvesting and oxygen evolution.	Oxygen	118-124	beaded filament structural protein 2	Homo sapiens	34-39
8876687-8	1996	It is known that recovery from damage induced by HU involves several enzymes such as flavin oxido-reductase, superoxide dismutase and catalase which are involved in the production or scavenging of O2 radicals; FA cells are deficient in the detoxification of oxygen and this could explain the response of FA cells to HU.	Oxygen	197-199	catalase	Homo sapiens	134-142
8876687-8	1996	It is known that recovery from damage induced by HU involves several enzymes such as flavin oxido-reductase, superoxide dismutase and catalase which are involved in the production or scavenging of O2 radicals; FA cells are deficient in the detoxification of oxygen and this could explain the response of FA cells to HU.	Oxygen	258-264	catalase	Homo sapiens	134-142
8895350-8	1996	We conclude that O2- plays a role in preventing NO inhibition of iNOS.	Oxygen	17-19	nitric oxide synthase 2	Homo sapiens	65-69
8893840-2	1996	A new mode of binding of ACh to AChE was found which involves the carboxyl oxygen of ACh interacting with Gly 118 and 119.	Oxygen	75-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-36
8874220-3	1996	Eotaxin stimulated the production of reactive oxygen metabolites as shown by lucigenin-dependent chemiluminescence and superoxide dismutase-inhibitable cytochrome C reduction.	Oxygen	46-52	C-C motif chemokine ligand 11	Homo sapiens	0-7
8873591-5	1996	For the 17 residue neuromodulin derived peptide, which is Ca2+ independent in its binding to calmodulin, oxygen collision rates demonstrate that one helical face of this peptide interacts strongly with calmodulin.	Oxygen	105-111	calmodulin 1	Homo sapiens	93-103
8873591-5	1996	For the 17 residue neuromodulin derived peptide, which is Ca2+ independent in its binding to calmodulin, oxygen collision rates demonstrate that one helical face of this peptide interacts strongly with calmodulin.	Oxygen	105-111	calmodulin 1	Homo sapiens	202-212
8874220-3	1996	Eotaxin stimulated the production of reactive oxygen metabolites as shown by lucigenin-dependent chemiluminescence and superoxide dismutase-inhibitable cytochrome C reduction.	Oxygen	46-52	cytochrome c, somatic	Homo sapiens	152-164
8912669-7	1996	.NO gas and the .NO-donors required molecular oxygen to induce the formation of the GAPDH thiyl radical, suggesting the possible involvement of higher nitrogen oxides.	Oxygen	46-52	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	84-89
8859081-9	1996	In animals with retinal ischemia secondary to loss of vasculature, treatment with supplemental oxygen therapy decreased stimulated retinal VEGF levels by approximately 70%.	Oxygen	95-101	vascular endothelial growth factor A	Homo sapiens	139-143
8798700-0	1996	Characterization of an upstream activation sequence and two Rox1p-responsive sites controlling the induction of the yeast HEM13 gene by oxygen and heme deficiency.	Oxygen	136-142	Rox1p	Saccharomyces cerevisiae S288C	60-65
8798700-2	1996	Its transcription has been shown to be induced 40-50-fold in response to oxygen or heme deficiency, in part through relief of repression exerted by Rox1p and in part by activation mediated by an upstream activation sequence (UAS).	Oxygen	73-79	Rox1p	Saccharomyces cerevisiae S288C	148-153
8897823-0	1996	Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.	Oxygen	94-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8897823-2	1996	In this study, we have quantitated HIF-1 DNA-binding activity and protein levels of the HIF-1 alpha and HIF-1 beta subunits in human HeLa cells exposed to O2 concentrations ranging from 0 to 20% in the absence or presence of 1 mM KCN to inhibit oxidative phosphorylation and cellular O2 consumption.	Oxygen	155-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40
8897823-2	1996	In this study, we have quantitated HIF-1 DNA-binding activity and protein levels of the HIF-1 alpha and HIF-1 beta subunits in human HeLa cells exposed to O2 concentrations ranging from 0 to 20% in the absence or presence of 1 mM KCN to inhibit oxidative phosphorylation and cellular O2 consumption.	Oxygen	155-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-99
8897823-2	1996	In this study, we have quantitated HIF-1 DNA-binding activity and protein levels of the HIF-1 alpha and HIF-1 beta subunits in human HeLa cells exposed to O2 concentrations ranging from 0 to 20% in the absence or presence of 1 mM KCN to inhibit oxidative phosphorylation and cellular O2 consumption.	Oxygen	284-286	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-99
8897823-3	1996	HIF-1 DNA-binding activity, HIF-1 alpha protein and HIF-1 beta protein each increased exponentially as cells were subjected to decreasing O2 concentrations, with a half maximal response between 1.5 and 2% O2 and a maximal response at 0.5% O2, both in the presence and absence of KCN.	Oxygen	138-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
8897823-4	1996	The HIF-1 response was greatest over O2 concentrations associated with ischemic/hypoxic events in vivo.	Oxygen	37-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-9
8897823-5	1996	These results provide evidence for the involvement of HIF-1 in O2 homeostasis and represent a functional characterization of the putative O2 sensor that initiates hypoxia signal transduction leading to HIF-1 expression.	Oxygen	63-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-59
8859081-0	1996	Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity.	Oxygen	52-58	vascular endothelial growth factor A	Homo sapiens	14-48
8859081-7	1996	Total VEGF messenger RNA and protein levels in retinas from animals on postnatal day 7 were decreased 55% and 85%, respectively, after 6 hours in 75% oxygen.	Oxygen	150-156	vascular endothelial growth factor A	Homo sapiens	6-10
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	Oxygen	251-257	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	Oxygen	251-257	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8798486-5	1996	Oxygen binding of red blood cells revealed a 40% decrease in the P50 (pH 7.4) and a low n value of 1.6 (normal: 2.6).	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	65-68
8923780-6	1996	Our findings support the hypothesis that GATA is a transcription factor for the Epo gene acting through the oxygen sensor.	Oxygen	108-114	erythropoietin	Homo sapiens	80-83
8899837-2	1996	PURPOSE: The oxidation of methionine in human Insulin-like Growth Factor I (hIGF-I) in aqueous solution was studied with respect to oxygen, visible light and sodium phosphate.	Oxygen	132-138	insulin like growth factor 1	Homo sapiens	46-74
8899837-3	1996	METHODS: Aqueous solutions of hIGF-I were prepared with different amounts of phosphate and dissolved oxygen.	Oxygen	101-107	insulin like growth factor 1	Homo sapiens	30-36
8902948-8	1996	Increase in [Ca2+]i due to oxygen-glucose deprivation was significant in CA1 and CA3 of the septic group and in all hippocampal regions of sham-operated group.	Oxygen	27-33	carbonic anhydrase 2	Rattus norvegicus	13-16
8982295-5	1996	Catalase, a scavenger of reactive oxygen metabolites (ROM), reversed the monocyte-induced inhibition of NK cell-mediated killing of blast cells, indicating that the inhibitory signal was mediated by products of the respiratory burst of monocytes.	Oxygen	34-40	catalase	Homo sapiens	0-8
8806769-6	1996	Peroxynitrite-induced LCL was 80 and 55% inhibitable by SOD and catalase, respectively, showing that there were O2.- and H2O2-dependent routes of chemiexcitation.	Oxygen	112-114	superoxide dismutase 1	Homo sapiens	56-59
8805668-1	1996	We recently reported that a hypoxia-responsive element mediates a novel pathway of transcriptional activation of the inducible nitric oxide synthase (iNOS) promoter in murine macrophages treated with IFN-gamma plus hypoxia (1% O2).	Oxygen	227-229	nitric oxide synthase 2, inducible	Mus musculus	150-154
8790408-1	1996	Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide.	Oxygen	61-67	superoxide dismutase 2, mitochondrial	Mus musculus	32-36
8853432-3	1996	TGF-beta 1 treatment also resulted in a 35% decrease in oxygen consumption, 50% inhibition of Na(+)-K(+)- ATPase activity, and a 57% decrease in gluconeogenesis.	Oxygen	56-62	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	0-10
8853432-4	1996	A concentration of 0.06 ng/ml TGF-beta 1 decreased oxygen consumption and induced glycolysis but had no effect on morphology and viability of RPTC.	Oxygen	51-57	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	30-40
8891300-0	1996	Oxygen-induced apoptosis in PC12 cells with special reference to the role of Bcl-2.	Oxygen	0-6	BCL2, apoptosis regulator	Rattus norvegicus	77-82
8891300-8	1996	To further characterize this oxygen-induced apoptosis at the molecular level, we used PC12 cells overexpressing the proto-oncogene bcl-2.	Oxygen	29-35	BCL2, apoptosis regulator	Rattus norvegicus	131-136
8790408-1	1996	Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide.	Oxygen	61-67	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
8908229-7	1996	In group Hal, PVR and SVR showed a biphasic raise (P &lt; 0.05), CO fell (P &lt; 0.05-P &gt; or = 0.05) and C (a-v)O2 rose (P &lt; 0.05).	Oxygen	115-117	PVR cell adhesion molecule	Sus scrofa	14-17
8806769-6	1996	Peroxynitrite-induced LCL was 80 and 55% inhibitable by SOD and catalase, respectively, showing that there were O2.- and H2O2-dependent routes of chemiexcitation.	Oxygen	112-114	catalase	Homo sapiens	64-72
8806776-10	1996	Glutamine synthetase is inactivated faster when added during the phase of rapid O2 uptake than when added before the beginning of the reaction.	Oxygen	80-82	glutamate-ammonia ligase	Homo sapiens	0-20
8781471-3	1996	In this investigation, O2 consumption by freshly isolated myocardial muscle segments from the left ventricular free wall of canine hearts was quantified by a Clark-type O2 electrode at 37 degrees C. S-nitroso-N-acetylpenicillamine (SNAP, 9 +/- 3% to 50 +/- 8%), bradykinin (BK, 14 +/- 3% to 30 +/- 5%), or carbachol (CCh, 15 +/- 4% to 29 +/- 4%) significantly attenuated tissue O2 consumption at doses of 10(-7) to 10(-4) mol/L (mean +/- SE, P &lt; .05).	Oxygen	23-25	kininogen 1	Canis lupus familiaris	262-272
8889117-7	1996	RESULTS: The average heart rate and oxygen consumption during the match were 146.5 (SD 9.25) beats min-1 and 2.25(0.59) litre min-1 respectively.	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	99-110
8924055-11	1996	Similarly, apolipoprotein-B100 integrity was preserved against oxygen radical attack in the presence of calcium antagonists.	Oxygen	63-69	apolipoprotein B	Homo sapiens	11-30
8781471-3	1996	In this investigation, O2 consumption by freshly isolated myocardial muscle segments from the left ventricular free wall of canine hearts was quantified by a Clark-type O2 electrode at 37 degrees C. S-nitroso-N-acetylpenicillamine (SNAP, 9 +/- 3% to 50 +/- 8%), bradykinin (BK, 14 +/- 3% to 30 +/- 5%), or carbachol (CCh, 15 +/- 4% to 29 +/- 4%) significantly attenuated tissue O2 consumption at doses of 10(-7) to 10(-4) mol/L (mean +/- SE, P &lt; .05).	Oxygen	23-25	kininogen 1	Canis lupus familiaris	274-276
8781471-8	1996	The inhibitory effects of BK and CCh on O2 consumption were not observed in failing cardiac tissue, but SNAP showed an unaltered inhibitory effect.	Oxygen	40-42	kininogen 1	Canis lupus familiaris	26-28
8865272-12	1996	In O2-exposed animals, EPO treatment increased the ability of both plasma (EPO 800) and BAL (EPO 400 and 800) to inhibit lipid peroxidation and decreased NSP in BAL (EPO 400).	Oxygen	3-5	erythropoietin	Homo sapiens	75-78
8948120-0	1996	The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation.	Oxygen	21-27	interferon gamma	Homo sapiens	77-86
8948120-0	1996	The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation.	Oxygen	21-27	interleukin 2	Homo sapiens	138-142
8836047-6	1996	IRP inhibition was prevented by separate or simultaneous addition of superoxide dismutase and catalase, showing that both O2-.	Oxygen	122-124	catalase	Homo sapiens	94-102
8769632-4	1996	Higher levels of TNF-alpha mRNA were seen in persons who had higher levels of arterial oxygen.	Oxygen	87-93	tumor necrosis factor	Homo sapiens	17-26
8883005-1	1996	The relation of daily energy expenditure (EE) and maximal oxygen uptake (VO2max) to plasma fibrinogen with reference to DNA polymorphism was analyzed in a random sample of men (N = 189), age 50-60.	Oxygen	58-64	fibrinogen beta chain	Homo sapiens	91-101
8865272-12	1996	In O2-exposed animals, EPO treatment increased the ability of both plasma (EPO 800) and BAL (EPO 400 and 800) to inhibit lipid peroxidation and decreased NSP in BAL (EPO 400).	Oxygen	3-5	erythropoietin	Homo sapiens	23-26
8865272-12	1996	In O2-exposed animals, EPO treatment increased the ability of both plasma (EPO 800) and BAL (EPO 400 and 800) to inhibit lipid peroxidation and decreased NSP in BAL (EPO 400).	Oxygen	3-5	erythropoietin	Homo sapiens	75-78
8865272-12	1996	In O2-exposed animals, EPO treatment increased the ability of both plasma (EPO 800) and BAL (EPO 400 and 800) to inhibit lipid peroxidation and decreased NSP in BAL (EPO 400).	Oxygen	3-5	erythropoietin	Homo sapiens	75-78
8751892-0	1996	Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils.	Oxygen	49-55	myeloperoxidase	Homo sapiens	30-45
8718890-6	1996	The ability of the three SHA oxygen atoms to closely duplicate the hydrogen-bonding pattern of these three water molecules in the native enzyme is postulated to account for the strong binding of this inhibitor to MPO.	Oxygen	29-35	myeloperoxidase	Homo sapiens	213-216
8772190-0	1996	Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers.	Oxygen	70-76	nuclear factor kappa B subunit 1	Homo sapiens	14-24
8772190-3	1996	Here, we show that activation of NF-kappaB by ER stress requires an increase in the intracellular levels of both reactive oxygen intermediates (ROIs) and Ca2+.	Oxygen	122-128	nuclear factor kappa B subunit 1	Homo sapiens	33-42
8765221-1	1996	The reaction of mammalian cytochrome P-450 2B4 with nitrogen monoxide and oxygen has been studied by surface-enhanced resonance Raman scattering (SERRS) to obtain sharp and definitive information in situ on the nature of the changes in the active site pocket.	Oxygen	74-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-42
8781540-6	1996	The activation of PMNLs with fMLP and A23187 enhanced O2- formation both in healthy subjects and in patients with atherosclerotic disease of the lower legs, however the increase was significantly less in the latter group.	Oxygen	54-56	formyl peptide receptor 1	Homo sapiens	29-33
8753788-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates genes whose products play key roles in maintaining O2 homeostasis.	Oxygen	164-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8710904-1	1996	Cu/Zn superoxide dismutase (Cu/Zn SOD) is a key enzyme in the metabolism of oxygen free radicals.	Oxygen	76-82	superoxide dismutase 1	Homo sapiens	0-26
8710904-1	1996	Cu/Zn superoxide dismutase (Cu/Zn SOD) is a key enzyme in the metabolism of oxygen free radicals.	Oxygen	76-82	superoxide dismutase 1	Homo sapiens	28-37
8865978-6	1996	A linear regression analysis demonstrated a significant relationship between ir-ET-1 concentrations and alveolar-arterial oxygen gradient (r = 0.49, p = 0.02) and mean airway pressure (r = 0.49, p = 0.02).	Oxygen	122-128	endothelin 1	Homo sapiens	80-84
8960379-5	1996	The active oxygen scavengers, superoxide dismutase and catalase, distinguished the extent to which active oxygen was involved in modifying cellular contractility.	Oxygen	106-112	catalase	Rattus norvegicus	55-63
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	72-78	tumor necrosis factor	Homo sapiens	30-33
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	108-110	tumor necrosis factor	Homo sapiens	30-33
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	139-145	tumor necrosis factor	Homo sapiens	30-33
8702551-10	1996	These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF-induced IL-1alpha expression, presumably superoxide.	Oxygen	45-47	tumor necrosis factor	Homo sapiens	121-124
8753788-1	1996	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates genes whose products play key roles in maintaining O2 homeostasis.	Oxygen	164-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
8758908-5	1996	Under low oxygen conditions, VEGF induction is inhibited in cells expressing a mutant inhibitory allele of Ha-ras (RasN17), indicating a direct role for Ras in modulating VEGF activity.	Oxygen	10-16	vascular endothelial growth factor A	Homo sapiens	29-33
8706348-7	1996	Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes.	Oxygen	70-76	interferon gamma	Homo sapiens	131-140
8706348-7	1996	Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes.	Oxygen	70-76	interleukin 2	Homo sapiens	219-223
8758908-5	1996	Under low oxygen conditions, VEGF induction is inhibited in cells expressing a mutant inhibitory allele of Ha-ras (RasN17), indicating a direct role for Ras in modulating VEGF activity.	Oxygen	10-16	vascular endothelial growth factor A	Homo sapiens	171-175
8922534-3	1996	We measured PMN production of superoxide anions (O2-) by cytochrome c reduction (see Babior, B.M.	Oxygen	49-51	cytochrome c, somatic	Homo sapiens	57-69
9035817-1	1996	The effect of C-reactive protein on oxygen metabolism and lysosomal activity of the human blood neutrophils was found to depend on its ability to conform and to render both the pro- and anti-inflammatory results.	Oxygen	36-42	C-reactive protein	Homo sapiens	14-32
8880247-8	1996	MEASUREMENTS AND RESULTS: Standard P50 was calculated from measured partial pressure of oxygen and of carbon dioxide, pH and oxygen saturation in mixed venous blood (SvO2) using the Severinghaus formula.	Oxygen	88-94	nuclear factor kappa B subunit 1	Homo sapiens	35-38
8880247-8	1996	MEASUREMENTS AND RESULTS: Standard P50 was calculated from measured partial pressure of oxygen and of carbon dioxide, pH and oxygen saturation in mixed venous blood (SvO2) using the Severinghaus formula.	Oxygen	125-131	nuclear factor kappa B subunit 1	Homo sapiens	35-38
8880247-15	1996	Because a decrease in P50 implies a low ratio of mixed venous oxygen tension (PvO2) to SvO2, a shift in P50 should be taken into account when using SvO2 as a measure of global oxygen availability.	Oxygen	62-68	nuclear factor kappa B subunit 1	Homo sapiens	22-25
8880247-15	1996	Because a decrease in P50 implies a low ratio of mixed venous oxygen tension (PvO2) to SvO2, a shift in P50 should be taken into account when using SvO2 as a measure of global oxygen availability.	Oxygen	176-182	nuclear factor kappa B subunit 1	Homo sapiens	22-25
8880247-15	1996	Because a decrease in P50 implies a low ratio of mixed venous oxygen tension (PvO2) to SvO2, a shift in P50 should be taken into account when using SvO2 as a measure of global oxygen availability.	Oxygen	176-182	nuclear factor kappa B subunit 1	Homo sapiens	104-107
8707878-14	1996	In addition, we found that AP-1 binding activities in chondrocytes exposed to low oxygen tensions was elevated, although the response was lower than that exhibited by fibroblasts exposed to the same range of oxygen concentrations.	Oxygen	82-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
8853468-2	1996	Seven highly trained endurance athletes with a mean maximum oxygen uptake of 65 ml.kg-1.min-1, performed two cycle ergometer tests to volitional exhaustion.	Oxygen	60-66	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
8707878-14	1996	In addition, we found that AP-1 binding activities in chondrocytes exposed to low oxygen tensions was elevated, although the response was lower than that exhibited by fibroblasts exposed to the same range of oxygen concentrations.	Oxygen	208-214	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
8755738-10	1996	These data taken together suggest that the L-arginine, dioxygen, and the BH4 binding sites are in close proximity in rH-iNOS.	Oxygen	55-63	nitric oxide synthase 2	Homo sapiens	120-124
8865322-1	1996	PURPOSE: The aim of this work was to study the kinetics of oxidation of methionine in human Insulin-like Growth Factor I (hIGF-I)1 in aqueous solution and in the solid state by the aid of quantification of oxygen.	Oxygen	206-212	insulin like growth factor 1	Homo sapiens	92-120
8865322-1	1996	PURPOSE: The aim of this work was to study the kinetics of oxidation of methionine in human Insulin-like Growth Factor I (hIGF-I)1 in aqueous solution and in the solid state by the aid of quantification of oxygen.	Oxygen	206-212	insulin like growth factor 1	Homo sapiens	122-130
8865322-4	1996	RESULTS: Second-order kinetics with respect to amount of protein and dissolved oxygen was found to be appropriate for the oxidation of methionine in hIGF-I.	Oxygen	79-85	insulin like growth factor 1	Homo sapiens	149-155
11667375-7	1996	A key intermediate in this oxidation is believed to be the phthalimide N-oxyl radical generated from NHPI and molecular oxygen using a Co(II) species.	Oxygen	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
8760128-6	1996	On the other hand, incubation of cells with NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), the enzyme responsible for .NO synthesis, results in increases in DSPC synthesis, cell ATP content, and cellular oxygen consumption.	Oxygen	245-251	nitric oxide synthase 2	Homo sapiens	103-124
8760033-2	1996	We have investigated whether cytochrome P-450 may act as an O2 sensor coupling hypoxia to K+ channel inhibition, by investigating the actions of P-450 inhibitors to modulate channel activity (recorded using patch-clamp techniques) in type I cells isolated from 8-to 12-day-old rat pups.	Oxygen	60-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	29-45
8760086-3	1996	ANG II (1 nM) infusion alone caused vasoconstriction with increased oxygen (55%) and glucose (98%) uptake and lactate (37%) and glycerol (64%) release.	Oxygen	68-74	angiotensinogen	Rattus norvegicus	0-6
8760086-4	1996	ANG II infusion during muscle contraction gave less vasoconstriction but increased the tension development during tetanic stimulation by 80% and increased the contraction-induced oxygen uptake and Rg" by plantaris and gastrocnemius red and white muscles.	Oxygen	179-185	angiotensinogen	Rattus norvegicus	0-6
8760132-2	1996	We measured TGF-beta peptide production by AEC2 and macrophages from lungs of adult male rats exposed to 100% oxygen for 48 h and then allowed to recover for up to 72 h in room air.	Oxygen	110-116	transforming growth factor, beta 1	Rattus norvegicus	12-20
8763865-0	1996	The influence of oxygen and carbon dioxide tension on the production of TNF alpha by activated macrophages.	Oxygen	17-23	tumor necrosis factor	Homo sapiens	72-81
8760132-6	1996	In contrast, TGF-beta peptide activity increased from undetectable levels in lung lavage from control rats to a peak of 1,470 +/- 743 pg/rat after 48 h oxygen exposure and 24 h recovery, while lavaged macrophage TGF-beta production in culture also increased threefold to a peak of 150 +/- 5 pg.	Oxygen	152-158	transforming growth factor, beta 1	Rattus norvegicus	13-21
8679214-6	1996	Northern blot analysis of lung mRNA isolated at 96 h of oxygen exposure revealed a 7-fold increase in CD54 (intercellular adhesion molecule-1 [ICAM-1]) and a 2.5-fold increase in TNF-alpha mRNAs respectively.	Oxygen	56-62	tumor necrosis factor	Mus musculus	179-188
9035458-1	1996	PURPOSE: To compare patients with heart failure due to Chagas" cardiomyopathy and maximal oxygen consumption greater than 20mL/kg-1/min-1 to normal individuals.	Oxygen	90-96	CD59 molecule (CD59 blood group)	Homo sapiens	132-137
9035730-4	1996	These pro-oxidants rapidly activate synthesis of low molecular weight antioxidants; LPS-dependently generated active oxygen forms in the liver of treated animals, which causes iNOS synthesis, are inactivated by the antioxidants; thus, accumulation of active oxygen species is decreased and iNOS synthesis is inhibited.	Oxygen	117-123	nitric oxide synthase 2, inducible	Mus musculus	176-180
9035730-4	1996	These pro-oxidants rapidly activate synthesis of low molecular weight antioxidants; LPS-dependently generated active oxygen forms in the liver of treated animals, which causes iNOS synthesis, are inactivated by the antioxidants; thus, accumulation of active oxygen species is decreased and iNOS synthesis is inhibited.	Oxygen	117-123	nitric oxide synthase 2, inducible	Mus musculus	290-294
9035730-4	1996	These pro-oxidants rapidly activate synthesis of low molecular weight antioxidants; LPS-dependently generated active oxygen forms in the liver of treated animals, which causes iNOS synthesis, are inactivated by the antioxidants; thus, accumulation of active oxygen species is decreased and iNOS synthesis is inhibited.	Oxygen	258-264	nitric oxide synthase 2, inducible	Mus musculus	176-180
9035730-4	1996	These pro-oxidants rapidly activate synthesis of low molecular weight antioxidants; LPS-dependently generated active oxygen forms in the liver of treated animals, which causes iNOS synthesis, are inactivated by the antioxidants; thus, accumulation of active oxygen species is decreased and iNOS synthesis is inhibited.	Oxygen	258-264	nitric oxide synthase 2, inducible	Mus musculus	290-294
8763865-3	1996	The results indicated that U937 cells stimulated with PMA produced up to 10 times more TNF alpha when incubated under tumour-relevant oxygen tensions of 1% rather than under aerobic conditions, i.e. 21% O2.	Oxygen	134-140	tumor necrosis factor	Homo sapiens	87-96
8763865-3	1996	The results indicated that U937 cells stimulated with PMA produced up to 10 times more TNF alpha when incubated under tumour-relevant oxygen tensions of 1% rather than under aerobic conditions, i.e. 21% O2.	Oxygen	203-205	tumor necrosis factor	Homo sapiens	87-96
8828672-6	1996	The decrement in VO2max on HA1 did not differ between groups, averaging 26% overall, despite higher (P &lt; 0.01) arterial hematocrit, hemoglobin concentration, and arterial O2 content in the erythrocyte-infused subjects.	Oxygen	18-20	Rho GTPase activating protein 45	Homo sapiens	27-30
21232289-0	1996	Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis.	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-56
8866334-3	1996	PGE1 (10 nM-10 microM) inhibited concentration-dependently formyl-methionyl-leucyl-phenylalanine (fMLP)-induced beta-glucuronidase and oxygen radical (O2.)	Oxygen	151-153	formyl peptide receptor 1	Homo sapiens	98-102
8866334-7	1996	The combination linsidomine (100 microM) plus IBMX (0.5 mM) did not additionally reduce beta-glucuronidase release, but abolished fMLP-stimulated O2.	Oxygen	146-148	formyl peptide receptor 1	Homo sapiens	130-134
8673608-2	1996	Cytochrome P450eryF is unusual in having alanine in place of this threonine and an ordered active site water molecule (Wat 519) which is hydrogen bonded to the substrate 5-hydroxyl group and is in position to operate as an acid catalyst required for cleaving dioxygen.	Oxygen	259-267	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	340-344	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	340-344	erythropoietin	Homo sapiens	101-115
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	340-344	vascular endothelial growth factor A	Homo sapiens	117-151
21232289-3	1996	The level of HIF-1 expression in cultured cells is proportional to the degree of hypoxia over the range of O(2) concentrations associated with physiologic and pathophysiologic conditions in vivo.	Oxygen	107-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-18
8663080-2	1996	The thiol-specific antioxidant protein (TSA) protects glutamine synthetase from inactivation by a metal-catalyzed oxidation (MCO) system comprised of dithiothreitol (DTT)/Fe3+/O2 but not by the ascorbate/Fe3+/O2 MCO system.	Oxygen	176-178	glutamate-ammonia ligase	Homo sapiens	54-74
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	265-269	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8663080-2	1996	The thiol-specific antioxidant protein (TSA) protects glutamine synthetase from inactivation by a metal-catalyzed oxidation (MCO) system comprised of dithiothreitol (DTT)/Fe3+/O2 but not by the ascorbate/Fe3+/O2 MCO system.	Oxygen	209-211	glutamate-ammonia ligase	Homo sapiens	54-74
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	265-269	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	265-269	erythropoietin	Homo sapiens	101-115
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	265-269	vascular endothelial growth factor A	Homo sapiens	117-151
21232289-2	1996	Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of genes whose products, including erythropoietin, vascular endothelial growth factor, and glycolytic enzymes, are involved in systemic, local, and cellular responses to hypoxia that either increase O(2) delivery or induce alternative metabolic pathways that do not require O(2).	Oxygen	340-344	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8691452-8	1996	Our results also suggest that the oxygens at C9 and C13 are involved in PKC binding, while the oxygen at C4 is of minimal significance.	Oxygen	34-41	protein kinase C alpha	Homo sapiens	72-75
8691452-8	1996	Our results also suggest that the oxygens at C9 and C13 are involved in PKC binding, while the oxygen at C4 is of minimal significance.	Oxygen	34-40	protein kinase C alpha	Homo sapiens	72-75
8660366-0	1996	Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.	Oxygen	101-107	erythropoietin	Homo sapiens	54-68
8660366-7	1996	Under hyperbaric oxygen, cobalt induction of erythropoietin mRNA was modestly suppressed while nickel induction was markedly enhanced.	Oxygen	17-23	erythropoietin	Homo sapiens	45-59
8662862-12	1996	The data from the reaction with O2 reveal a remarkable similarity in the kinetic, equilibrium, and optical properties of caa3 and the electrostatic complex cytochrome c/cytochrome c oxidase.	Oxygen	32-34	cytochrome c, somatic	Homo sapiens	156-168
8662862-12	1996	The data from the reaction with O2 reveal a remarkable similarity in the kinetic, equilibrium, and optical properties of caa3 and the electrostatic complex cytochrome c/cytochrome c oxidase.	Oxygen	32-34	cytochrome c, somatic	Homo sapiens	169-181
8655601-4	1996	Exposure of human or bovine endothelial cells to low oxygen tensions results in a profound decrease in the transcript for cNOS and a corresponding fall in cNOS protein levels.	Oxygen	53-59	nitric oxide synthase 3	Bos taurus	122-126
8818231-0	1996	The iron(II)/reductant (DH2)-induced activation of dioxygen for the demethylation of N-methylanilines: reaction mimic for the cytochrome P-450/reductase system.	Oxygen	51-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	126-152
9070382-2	1996	The benefits of ACE inhibition include not only a reduction in blood pressure but also improved insulin responsiveness, prevention of potassium loss, diminished myocardial oxygen demand, suppression of catecholamines, and interaction with bradykinin and prostaglandins.	Oxygen	172-178	angiotensin I converting enzyme	Homo sapiens	16-19
8654144-2	1996	A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils.	Oxygen	281-287	integrin subunit beta 2	Homo sapiens	148-152
8655601-4	1996	Exposure of human or bovine endothelial cells to low oxygen tensions results in a profound decrease in the transcript for cNOS and a corresponding fall in cNOS protein levels.	Oxygen	53-59	nitric oxide synthase 3	Bos taurus	155-159
8655601-6	1996	Cobalt inhibited the expression of cNOS transcripts, suggesting a mechanism comparable to that by which oxygen tension regulates expression of other vasoregulatory genes.	Oxygen	104-110	nitric oxide synthase 3	Homo sapiens	35-39
8743501-3	1996	NOS catalyzes the NADPH- and oxygen-dependent oxygenation of L-arginine to NO plus L-citrulline in a reaction that requires at least six cofactors including NADPH, FAD, FMN, tetrahydrobiopterin, heme, and calmodulin.	Oxygen	29-35	calmodulin 1	Homo sapiens	205-215
9387623-4	1996	The number of GCR in the patients was greatly increased when these patients were treated with oxygen (P &lt; 0.01).	Oxygen	94-100	nuclear receptor subfamily 3 group C member 1	Homo sapiens	14-17
8884749-5	1996	A beta causes plasma membrane lipid peroxidation, impairment of ion-motive ATPases, glutamate uptake, uncoupling of a G-protein linked receptor, and generation of reactive oxygen species.	Oxygen	172-178	amyloid beta precursor protein	Homo sapiens	0-6
12226312-3	1996	This led to a large increase in the capacity for AOX respiration, defined as the amount of salicylhydroxamic acid-sensitive O2 uptake by cells in the presence of potassium cyanide.	Oxygen	124-126	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	49-52
12226312-8	1996	The signals influencing Aox1 gene expression are discussed with regard to the potential function(s) of AOX to modulate tricarboxylic acid cycle metabolism and/or to prevent the generation of active oxygen species by the mitochondrial electron transport chain.	Oxygen	198-204	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	24-28
9387623-6	1996	These results indicate that the function of adrenal cortex may be improved by the compensation mechanism of the patients, but the lower GCR number was the result of lacking of oxygen in the patients.	Oxygen	176-182	nuclear receptor subfamily 3 group C member 1	Homo sapiens	136-139
9387623-7	1996	The number of GCR may be improved by inhalation of oxygen.	Oxygen	51-57	nuclear receptor subfamily 3 group C member 1	Homo sapiens	14-17
8695565-1	1996	BACKGROUND: To determine whether a higher level of copper zinc superoxide dismutase (CuZnSOD) can reduce the severity of oxygen induced retinopathy (OIR) in a mouse model.	Oxygen	121-127	superoxide dismutase 1, soluble	Mus musculus	85-92
8630079-4	1996	We concluded that ferric Cyt c produced some radical species from water-soluble oxygen in the presence of CL (CL-Cyt c system) and that radicals oxidized free LA or CL.	Oxygen	80-86	cytochrome c, somatic	Homo sapiens	25-30
8630079-4	1996	We concluded that ferric Cyt c produced some radical species from water-soluble oxygen in the presence of CL (CL-Cyt c system) and that radicals oxidized free LA or CL.	Oxygen	80-86	cytochrome c, somatic	Homo sapiens	113-118
8629777-11	1996	Because ventilation with exhaled gas contains as much as 4% CO2 and less oxygen than air, it may have adverse effects during CPR.	Oxygen	73-79	cytochrome p450 oxidoreductase	Homo sapiens	125-128
8635877-7	1996	In contrast, depletion of oxygen coincided with necrotic cell death in Rat1-T1 spheroids and proliferation arrest in MR1 cultures.	Oxygen	26-32	major histocompatibility complex, class I-related	Rattus norvegicus	117-120
8743726-7	1996	These facts and our previous findings on generating of active oxygen species by proteinases give us grounds to suppose that minor active oxygen species, endogenous for the "proteinase-substrate" system, can participate in the catalytic function of some proteinases.	Oxygen	62-68	endogenous retrovirus group K member 25	Homo sapiens	172-183
8743726-7	1996	These facts and our previous findings on generating of active oxygen species by proteinases give us grounds to suppose that minor active oxygen species, endogenous for the "proteinase-substrate" system, can participate in the catalytic function of some proteinases.	Oxygen	137-143	endogenous retrovirus group K member 25	Homo sapiens	172-183
8634256-0	1996	Stopped-flow, laser-flash photolysis studies on the reactions of CO and O2 with the cytochrome caa3 complex from Bacillus subtilis: conservation of electron transfer pathways from cytochrome c to O2.	Oxygen	72-74	cytochrome c, somatic	Homo sapiens	84-96
8634256-0	1996	Stopped-flow, laser-flash photolysis studies on the reactions of CO and O2 with the cytochrome caa3 complex from Bacillus subtilis: conservation of electron transfer pathways from cytochrome c to O2.	Oxygen	196-198	cytochrome c, somatic	Homo sapiens	84-96
8634256-7	1996	A kinetic model is proposed in which fully reduced oxidase first combines with O2 and then electron transfer commences from both cytochrome a and a3, followed rapidly by electron input from CuA and the cytochrome c domain.	Oxygen	79-81	cytochrome c, somatic	Homo sapiens	202-214
8639550-1	1996	Inducible nitric oxide synthase (iNOS) catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L-arginine and O2.	Oxygen	135-137	nitric oxide synthase 2	Homo sapiens	0-31
8639550-1	1996	Inducible nitric oxide synthase (iNOS) catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L-arginine and O2.	Oxygen	135-137	nitric oxide synthase 2	Homo sapiens	33-37
8666673-7	1996	Purified bone marrow PMNS from wild-type mice released significant amounts of O2- when adherent to fibrinogen-, fibronectin-, or collagen-coated surfaces, in the presence of activating agents such as tumor necrosis factor (TNF) or formyl-methionyl-leucyl-phenylalanine, as described for human PMNs.	Oxygen	78-80	tumor necrosis factor	Mus musculus	200-221
8792878-8	1996	At DO2crit, i.e., at the transition to supply-dependent O2 consumption, the tissue PCO2 started to increase rapidly, as did the tissue-venous PCO2 difference.	Oxygen	4-6	PCO2	Sus scrofa	83-87
8621799-0	1996	Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure.	Oxygen	36-38	erythropoietin	Homo sapiens	11-25
8647183-4	1996	Furthermore, studies with thymocytes demonstrated that the induction of nur77, a gene shown to be involved in thymocyte apoptosis signaled through the TCR or its surrogates, is not inhibited by NAC or dependent upon molecular oxygen.	Oxygen	226-232	nuclear receptor subfamily 4 group A member 1	Homo sapiens	72-77
8666673-7	1996	Purified bone marrow PMNS from wild-type mice released significant amounts of O2- when adherent to fibrinogen-, fibronectin-, or collagen-coated surfaces, in the presence of activating agents such as tumor necrosis factor (TNF) or formyl-methionyl-leucyl-phenylalanine, as described for human PMNs.	Oxygen	78-80	tumor necrosis factor	Mus musculus	223-226
8621627-1	1996	Human neutrophil microbicidal activity is largely mediated by reactive species generated by the oxygen-dependent myeloperoxidase (MPO) system.	Oxygen	96-102	myeloperoxidase	Homo sapiens	113-128
8924517-4	1996	The altered ratio of NO/superoxide anion (O2-) production has been proposed to alleviate intrinsic inhibition of the transcription factor NF kappa B and lead to enhanced expression of adhesion molecules and chemotactic factors at the endothelial surface.	Oxygen	42-44	nuclear factor kappa B subunit 1	Homo sapiens	138-148
8619027-1	1996	We have used very low-frequency electron paramagnetic resonance (EPR) oximetry to measure the change in oxygen concentration (delta pO2) due to change in breathing atmosphere in FSa and NFSa fibrosarcomas implanted in the legs of C3H mice infused with perfluoro-octylbromine (PFOB).	Oxygen	104-110	RIKEN cDNA 4932438A13 gene	Mus musculus	178-181
8620022-5	1996	Also, the phase plot of the signal for compound III versus the oxygen concentration for Coprinus peroxidase differs from the corresponding phase plots obtained using other peroxidases.	Oxygen	63-69	peroxidase	Glycine max	97-107
8622636-12	1996	E3330 may suppress the production of active oxygen species serving as common messengers to activate NF-kappa B.	Oxygen	44-50	nuclear factor kappa B subunit 1	Homo sapiens	100-110
8774793-4	1996	Low oxygen levels can stimulate cellular processes, such as the production of tumor necrosis factor, interleukin (IL)-1, IL-8, and nuclear factor kappa B. Kupffer cell-mediated alterations in cocultured hepatocyte function are altered by pre-exposure to hypoxic culture conditions, whereas superoxide production, intracellular pH, and adenosine triphosphate levels are decreased by hypoxia.	Oxygen	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8620022-7	1996	Substituting NADH with dihydroxyfumaric acid as a substrate, oscillations in the oxygen concentration were observed for about 1.5 h when a concentrated solution of this substrate was continuously fed to a solution containing horseradish peroxidase.	Oxygen	81-87	peroxidase	Glycine max	237-247
8621627-1	1996	Human neutrophil microbicidal activity is largely mediated by reactive species generated by the oxygen-dependent myeloperoxidase (MPO) system.	Oxygen	96-102	myeloperoxidase	Homo sapiens	130-133
8726952-2	1996	We investigated the oxygen concentration received when oxygen was supplied at flow rates between 0 and 6 L.min-1 into the proximal ventilator tubing or the nasal mask whilst patients were ventilated with air.	Oxygen	20-26	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
8635221-5	1996	Des-alpha-Arg141 hemoglobin had a higher oxygen affinity (P50, 5.51 mm Hg; control, 19.94 mm Hg [P50 is the partial pressure of oxygen that gives 50% of the saturation of hemoglobin]) and a lower apparent cooperativity (Hill coefficient: n, 1.02; control, 2.24) than unhydrolyzed hemoglobin.	Oxygen	41-47	nuclear factor kappa B subunit 1	Homo sapiens	58-61
8635221-5	1996	Des-alpha-Arg141 hemoglobin had a higher oxygen affinity (P50, 5.51 mm Hg; control, 19.94 mm Hg [P50 is the partial pressure of oxygen that gives 50% of the saturation of hemoglobin]) and a lower apparent cooperativity (Hill coefficient: n, 1.02; control, 2.24) than unhydrolyzed hemoglobin.	Oxygen	128-134	nuclear factor kappa B subunit 1	Homo sapiens	97-100
8619857-4	1996	Although Bcl-2 has been shown to act as an antioxidant under certain conditions, additional functions have emerged from studies under low oxygen pressure.	Oxygen	138-144	BCL2 apoptosis regulator	Homo sapiens	9-14
8928825-4	1996	eNOS protein expression was 2.7-fold greater at higher oxygen tension; eNOS upregulation was also evident after 24 h. Inducible NOS protein was not detectable by immunoblot at either level of oxygenation.	Oxygen	55-61	nitric oxide synthase 3	Homo sapiens	0-4
8928825-5	1996	In the lung, the effect of oxygen on eNOS expression may be specific to the endothelium, as eNOS expression in bronchiolar epithelial cells of Clara cell lineage was not altered by varying oxygen tension.	Oxygen	27-33	nitric oxide synthase 3	Homo sapiens	37-41
8928825-6	1996	The oxygen-related increase in eNOS protein in the fetal PAEC was associated with 2.5-fold greater NOS enzymatic activity.	Oxygen	4-10	nitric oxide synthase 3	Homo sapiens	31-35
8928825-8	1996	Thus eNOS gene expression in ovine fetal PAEC is upregulated by oxygen, and this is mediated at the level of gene transcription or mRNA stability.	Oxygen	64-70	nitric oxide synthase 3	Homo sapiens	5-9
9081618-1	1996	The haematopoietic growth factor erythropoietin is the primary regulator of mammalian erythropoiesis and is produced by the kidney and the liver in an oxygen-dependent manner.	Oxygen	151-157	erythropoietin	Homo sapiens	33-47
8726952-2	1996	We investigated the oxygen concentration received when oxygen was supplied at flow rates between 0 and 6 L.min-1 into the proximal ventilator tubing or the nasal mask whilst patients were ventilated with air.	Oxygen	55-61	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
8726952-9	1996	However, there was no significant difference between the two routes in the inspired oxygen concentration achieved at all flow rates: 1 L.min-1 supplied approximately 31% oxygen; 2 L.min-1 37%; 3 L.min-1 40%; and 4 L.min-1 44%.	Oxygen	170-176	CD59 molecule (CD59 blood group)	Homo sapiens	137-142
8675426-0	1996	Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients.	Oxygen	21-27	tachykinin precursor 1	Homo sapiens	55-66
8708165-11	1996	CONCLUSIONS: This study demonstrates that patients with high post operative oxygen consumption after elective cardiac surgery have higher circulating levels of endotoxin, TNF and IL-6 and also have more symptoms of post-perfusion syndrome.	Oxygen	76-82	tumor necrosis factor	Homo sapiens	171-174
8675426-3	1996	The present study evaluated the effect of an exposure to hyperbaric oxygen on the content of substance P in the nasal mucosa of patients affected by cluster headache.	Oxygen	68-74	tachykinin precursor 1	Homo sapiens	93-104
8675426-7	1996	A marked decrease in the content of immunoreactivity for substance P was found in the patients exposed to hyperbaric oxygen.	Oxygen	117-123	tachykinin precursor 1	Homo sapiens	57-68
8846934-5	1996	The substitution of HbF biosynthesis way to HbA (indicating higher tissue then HbF oxygen-exchange ability) is supposedly the reason of EPO secretion drop after delivery.	Oxygen	83-89	erythropoietin	Homo sapiens	136-139
8708165-11	1996	CONCLUSIONS: This study demonstrates that patients with high post operative oxygen consumption after elective cardiac surgery have higher circulating levels of endotoxin, TNF and IL-6 and also have more symptoms of post-perfusion syndrome.	Oxygen	76-82	interleukin 6	Homo sapiens	179-183
9148594-1	1996	In vitro influence of sodium selenite on cytochrome P-450-dependent formation of active oxygen species on lipid peroxidation (LPO) in rat liver microsomes was studied.	Oxygen	88-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-57
8606506-9	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta and the G PLC-receptor pathway is particularly regulated by physiologically relevant periods of hypoxia/reoxygenation.	Oxygen	17-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8606506-9	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta and the G PLC-receptor pathway is particularly regulated by physiologically relevant periods of hypoxia/reoxygenation.	Oxygen	17-23	tumor necrosis factor	Homo sapiens	109-118
8606506-9	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta and the G PLC-receptor pathway is particularly regulated by physiologically relevant periods of hypoxia/reoxygenation.	Oxygen	17-23	interleukin 1 beta	Homo sapiens	123-132
8614137-5	1996	Groups B1 and B2 had significantly lower mixed venous oxygen saturation (39.2% vs 52.5% in group A; p &lt; 0.001), greater level of inotropic need (p &lt; 0.02), greater impairment of mental status, and lower ratio of right ventricular ejection fraction to inotropic need (0.37 vs 0.56 for group A; p &lt; 0.02) before left ventricular-assist device implantation.	Oxygen	54-60	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	7-16
8710749-1	1996	PURPOSE: The effects of transfection with the human Cu, Zn-superoxide dismutase (hSOD)4 gene on active oxygen-induced cytotoxicity in rat skin fibroblasts (FR) were studied for the purpose of developing the novel delivery system of hSOD using hSOD gene.	Oxygen	103-109	superoxide dismutase 1	Homo sapiens	81-85
8710749-4	1996	The effects of transfection with the hSOD gene on active oxygen-induced cytotoxicity were assessed by comparing the number of surviving cells and the level of lipid peroxidation in host and transformants after exposure to X/XO system.	Oxygen	57-63	superoxide dismutase 1	Homo sapiens	37-41
8606506-1	1996	The purpose of these studies was to examine the sensitivity of the PIP 2-PLC-transducing pathway (GPLC) and its relationship to the respiratory burst in human polymorphonuclear leukocytes (PMN) stimulated by IL-8, TNF-alpha, or IL-1 beta during sequential changes in buffer oxygen tension from normoxia (pO2 = 180-200 mm Hg), to hypoxia (pO2 &lt; 30 mm Hg) and then reoxygenation (pO2 &gt; 140 mm Hg).	Oxygen	274-280	prolactin induced protein	Homo sapiens	67-70
27405946-2	1996	In the carotid body and pulmonary neuroepithelial bodies a heme-containing nicotinamide-adenine dinucleotide phosphate oxidase-coupled potassium channel serves as an oxygen sensor.	Oxygen	166-172	dual oxidase 2	Homo sapiens	75-126
8596546-9	1996	Growth hormone improved cardiac output, particularly during exercise (from 7.4+/-0.7 to 9.7+/-0.9 liters per minute, P=0.003), and enhanced ventricular work, despite reductions in myocardial oxygen consumption (from 56+/-6 to 39+/-5 ml per minute, P=0.005) and energy production (from 1014+/-100 to 701+/-80 J per minute, P=0.002).	Oxygen	191-197	growth hormone 1	Homo sapiens	0-14
8867328-4	1996	In the former case, cytochrome c and delta p play a very similar role in the compensation for a decrease in the respiration rate caused by lowered oxygen concentration, while in the latter case changes in delta p activate cytochrome oxidase much stronger than changes in the reduction level of cytochrome c.	Oxygen	147-153	cytochrome c, somatic	Homo sapiens	20-32
8608803-6	1996	This system is characterized by the partial reconstitution of O-(2) production in an Epstein-Barr virus (EBV)-transformed lymphoblastoid B cell line from a patient with p67-phox-deficient CGD by transfection with an expression plasmid containing the 67-phox cDNA in the sense orientation.	Oxygen	62-67	CD33 molecule	Homo sapiens	169-172
8852426-4	1996	The generation of AP-sites and SSB was dependent on molecular oxygen and could be suppressed by the addition of catalase.	Oxygen	62-68	catalase	Homo sapiens	112-120
8598053-2	1996	All pos9 mutants (pos for peroxide sensitivity) were hypersensitive to methylviologene, hyperbaric oxygen or hydrogen peroxide, but grew similarly to the wild-type under all other conditions tested.	Oxygen	99-105	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	4-8
8606391-5	1996	Recently, an optical method (optode) using fluorescent technology has been developed for measurement of oxygen tension in subcutaneous tissue (P sgO2).	Oxygen	104-110	shugoshin 2	Homo sapiens	145-149
8769856-5	1996	These data indicate that modulation of astrocyte properties during oxygen deprivation results, in part, from intracellular glucose depletion and subsequent expression of GRP78, which sustains generation of neuroprotective IL-6 under the stress of H/R.	Oxygen	67-73	heat shock protein family A (Hsp70) member 5	Homo sapiens	170-175
8769856-5	1996	These data indicate that modulation of astrocyte properties during oxygen deprivation results, in part, from intracellular glucose depletion and subsequent expression of GRP78, which sustains generation of neuroprotective IL-6 under the stress of H/R.	Oxygen	67-73	interleukin 6	Homo sapiens	222-226
8605038-4	1996	These results suggest that MP plays a role as an absorber of active oxygen species and prevents phagocytes from self-destruction.	Oxygen	68-74	myeloperoxidase	Homo sapiens	27-29
8852931-5	1996	In addition, the activity of glutamine synthetase, which is known as an enzyme-highly sensitive to reactive oxygen, was decreased in the cerebral cortex of SAMP8 from 4- to 8-weeks of age.	Oxygen	108-114	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	29-49
8643669-4	1996	The multiphasic kinetics in cytochrome c oxidase can largely be attributed to the presence Of CuA as the donor of a fourth electron, which rereduces the originally oxidized low-spin heme and completes the reduction of O2 to water.	Oxygen	218-220	cytochrome c, somatic	Homo sapiens	28-40
8643669-9	1996	We conclude that a single bound ubiquinone molecule in cytochrome bo3 is capable of fast rereduction of heme b and that the reaction with O2 is quite similar in quinol and cytochrome c oxidases.	Oxygen	138-140	cytochrome c, somatic	Homo sapiens	172-184
11666284-6	1996	Oxygen atom transfer from LMoO(2)(S(2)PPr(2)) to PPh(3) was first-order with respect to reactants, with an overall second-order rate constant of 2.5(3) x 10(-)(4) M(-)(1).s(-)(1) at 30 degrees C. In toluene at 40 degrees C, all the above complexes catalyzed the oxidation of PPh(3) by Me(2)SO, with turnover rates of ca.	Oxygen	0-6	caveolin 1	Homo sapiens	49-55
11666284-6	1996	Oxygen atom transfer from LMoO(2)(S(2)PPr(2)) to PPh(3) was first-order with respect to reactants, with an overall second-order rate constant of 2.5(3) x 10(-)(4) M(-)(1).s(-)(1) at 30 degrees C. In toluene at 40 degrees C, all the above complexes catalyzed the oxidation of PPh(3) by Me(2)SO, with turnover rates of ca.	Oxygen	0-6	caveolin 1	Homo sapiens	275-281
8651451-7	1996	Catalase activity was determined by measuring oxygen production with a Yellow Springs Biological Oxygen monitor and oxygen electrode.	Oxygen	46-52	catalase	Mus musculus	0-8
8573194-4	1996	Superoxide dismutase (SOD) inhibited the rate of cytochrome c reduction and decreased the apparent rate of oxygen consumption by several DHLA/o-naphthoquinone systems.	Oxygen	107-113	superoxide dismutase 1	Homo sapiens	0-20
8573194-4	1996	Superoxide dismutase (SOD) inhibited the rate of cytochrome c reduction and decreased the apparent rate of oxygen consumption by several DHLA/o-naphthoquinone systems.	Oxygen	107-113	superoxide dismutase 1	Homo sapiens	22-25
8573194-5	1996	SOD also inhibited the rate of quinol oxidation by oxygen, after quinone reduction by a stoichiometric amount of DHLA.	Oxygen	51-57	superoxide dismutase 1	Homo sapiens	0-3
8639657-8	1996	Cleavage of DNA by these sulfur heterocycles is diminished by the removal of molecular oxygen from the reaction medium, by the radical scavengers methanol, ethanol, and mannitol, and by the enzyme catalase.	Oxygen	87-93	catalase	Homo sapiens	197-205
8639657-13	1996	The marked effect of catalase further suggests that molecular oxygen is converted to hydrogen peroxide which ultimately cleaves DNA via a trace metal-dependent Fenton reaction.	Oxygen	62-68	catalase	Homo sapiens	21-29
8651451-7	1996	Catalase activity was determined by measuring oxygen production with a Yellow Springs Biological Oxygen monitor and oxygen electrode.	Oxygen	97-103	catalase	Mus musculus	0-8
8651451-7	1996	Catalase activity was determined by measuring oxygen production with a Yellow Springs Biological Oxygen monitor and oxygen electrode.	Oxygen	116-122	catalase	Mus musculus	0-8
8611159-1	1996	Recent studies have indicated that regulatory mechanisms underlying the oxygen-dependent expression of the haematopoietic growth factor erythropoietin are widely operative in non-erythropoietin-producing cells and are involved in the regulation of other genes.	Oxygen	72-78	erythropoietin	Homo sapiens	136-150
8779917-4	1996	The functional expression of CFTR by the stable transfection of mouse mammary carcinoma cells, C1271, with human epithelial CFTR cDNA resulted in a stimulated metabolism, since both basal and cAMP-inducible O2 consumption were increased compared with mock-transfected cells.	Oxygen	207-209	CF transmembrane conductance regulator	Homo sapiens	124-128
8779917-5	1996	The stimulated (but not basal) O2 consumption was inhibited by diphenyl-2-carboxylic acid (DPC), a known inhibitor of CFTR.	Oxygen	31-33	CF transmembrane conductance regulator	Homo sapiens	118-122
8611159-9	1996	These findings indicate that similarities with erythropoietin regulation extend to the oxygen-dependent regulation of genes encoding glucose transporters and glycolytic enzymes but not to the regulation of mitochondrial transcripts, and they show that in glucose metabolism regulation by this system is isoenzyme- or isoform-specific.	Oxygen	87-93	erythropoietin	Homo sapiens	47-61
8573025-3	1996	RESULTS: The vascular endothelial cell may produce nitric oxide, endothelins, prostaglandins, and renin-angiotension products in response to chemical stimuli such as acetylcholine and bradykinin, to changes in blood pressure and vessel wall stress, to changes in local oxygen levels, and to other local stimuli.	Oxygen	269-275	renin	Homo sapiens	98-103
8573025-3	1996	RESULTS: The vascular endothelial cell may produce nitric oxide, endothelins, prostaglandins, and renin-angiotension products in response to chemical stimuli such as acetylcholine and bradykinin, to changes in blood pressure and vessel wall stress, to changes in local oxygen levels, and to other local stimuli.	Oxygen	269-275	kininogen 1	Homo sapiens	184-194
8620332-5	1996	Both superoxide dismutase and catalase effectively inhibit the mitogenic activity of oxidized LDL, suggesting involvement of reactive oxygen intermediates.	Oxygen	134-140	catalase	Homo sapiens	30-38
8611159-1	1996	Recent studies have indicated that regulatory mechanisms underlying the oxygen-dependent expression of the haematopoietic growth factor erythropoietin are widely operative in non-erythropoietin-producing cells and are involved in the regulation of other genes.	Oxygen	72-78	erythropoietin	Homo sapiens	179-193
8689403-7	1996	TNF-alpha was also associated with dose-related increases in oxygen uptake, and greater biliary concentrations of glutathione.	Oxygen	61-67	tumor necrosis factor	Rattus norvegicus	0-9
8824885-2	1996	In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development.	Oxygen	129-131	superoxide dismutase 1	Homo sapiens	75-101
8824885-2	1996	In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development.	Oxygen	129-131	superoxide dismutase 1	Homo sapiens	112-116
8670726-0	1996	Retinal vascular endothelial growth factor (VEGF) mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy.	Oxygen	114-120	vascular endothelial growth factor A	Homo sapiens	8-42
8670726-0	1996	Retinal vascular endothelial growth factor (VEGF) mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy.	Oxygen	114-120	vascular endothelial growth factor A	Homo sapiens	44-48
8670726-10	1996	These results indicate that VEGF mRNA abundance is regulated during retinal vascularization and is increased in relation to oxygen induced neovascularization, suggesting that VEGF may play an important role in both normal retinal vessel development and in the pathophysiology of retinopathy of prematurity.	Oxygen	124-130	vascular endothelial growth factor A	Homo sapiens	28-32
8670726-10	1996	These results indicate that VEGF mRNA abundance is regulated during retinal vascularization and is increased in relation to oxygen induced neovascularization, suggesting that VEGF may play an important role in both normal retinal vessel development and in the pathophysiology of retinopathy of prematurity.	Oxygen	124-130	vascular endothelial growth factor A	Homo sapiens	175-179
8603849-0	1996	Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation.	Oxygen	0-6	fibroblast growth factor 2	Homo sapiens	67-97
8576072-10	1996	We propose that the insertion of the transposon in cells grown in the presence of high oxygen levels has led to the generation of a cellular redox state resembling either reduced oxygen or anaerobiosis, thereby resulting in increased expression of hemA, as well as the accumulation of spectral complex formation.	Oxygen	87-93	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	248-252
8576072-10	1996	We propose that the insertion of the transposon in cells grown in the presence of high oxygen levels has led to the generation of a cellular redox state resembling either reduced oxygen or anaerobiosis, thereby resulting in increased expression of hemA, as well as the accumulation of spectral complex formation.	Oxygen	179-185	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	248-252
8929607-1	1996	Arteriovenous O2 content (a-vCO2) differences increase during exercise in normal subjects through several mechanisms including PO2, O2 pressure at which hemoglobin (Hb) is half saturated with O2 (P50), and Hb concentration changes.	Oxygen	30-32	nuclear factor kappa B subunit 1	Homo sapiens	196-199
8929607-1	1996	Arteriovenous O2 content (a-vCO2) differences increase during exercise in normal subjects through several mechanisms including PO2, O2 pressure at which hemoglobin (Hb) is half saturated with O2 (P50), and Hb concentration changes.	Oxygen	30-32	nuclear factor kappa B subunit 1	Homo sapiens	196-199
8604000-6	1996	Our results also indicate that specific and azurophil granules have to be in very close contact to allow the generated oxygen metabolites to reach and react with myeloperoxidase.	Oxygen	119-125	myeloperoxidase	Homo sapiens	162-177
8705396-4	1996	Changes in GPLD activation correlated best with changes in O2-production during the hypoxia to hypoxia/reoxygenation transition induced by TNF-alpha-Fn and IL-1 beta +/- Fn.	Oxygen	59-61	tumor necrosis factor	Homo sapiens	139-148
8865706-5	1996	3 l. min(-1) oxygen inhalation through the face mask was enough to avoid postoperative hypoxemia in both groups; the mean values of Spo2 were 99% in G group and 97.9% in E group.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	5-11
8865706-9	1996	In conclusion, there is a high incidence of postoperative hypoxemia for several hours in the ward, which can be relieved by 3 l. min(-1) oxygen inhalation with face mask.	Oxygen	137-143	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
8705396-4	1996	Changes in GPLD activation correlated best with changes in O2-production during the hypoxia to hypoxia/reoxygenation transition induced by TNF-alpha-Fn and IL-1 beta +/- Fn.	Oxygen	59-61	interleukin 1 beta	Homo sapiens	156-165
8705396-5	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta, and activation of the GPLD-pathway appears to be highly sensitive to hypoxia and hypoxia/reoxygenation.	Oxygen	17-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8705396-5	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta, and activation of the GPLD-pathway appears to be highly sensitive to hypoxia and hypoxia/reoxygenation.	Oxygen	17-23	tumor necrosis factor	Homo sapiens	109-118
8705396-5	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta, and activation of the GPLD-pathway appears to be highly sensitive to hypoxia and hypoxia/reoxygenation.	Oxygen	17-23	interleukin 1 beta	Homo sapiens	123-132
8561775-5	1996	Furthermore, cells subjected to a severe hypoxic condition (0.5% O2) for 24 hours exerted a 22% reduction in MR expression and a 64% increase in GR expression.	Oxygen	65-67	nuclear receptor subfamily 3 group C member 1	Homo sapiens	145-147
8551333-3	1996	Infection of hippocampal cultures with Bcl-2 vectors enhanced neuron survivorship after exposure to adriamycin, a potent oxygen radical generator.	Oxygen	121-127	BCL2 apoptosis regulator	Homo sapiens	39-44
8569798-3	1996	The breaking activity was inhibited in the presence of superoxide dismutase, catalase, hydroxyl radical scavengers, spin trapping agents, thiol compounds and metal chelators, and also by removal of dissolved oxygen from the incubation mixture.	Oxygen	208-214	catalase	Mus musculus	77-85
9244168-2	1996	Lipopolysaccharide impaired oxygen consumption in a dose-dependent manner which was shown to be mediated by mitochondrial dysfunction and could be augmented by pretreatment of the cells with interferon-gamma.	Oxygen	28-34	interferon gamma	Homo sapiens	191-207
8550558-1	1996	A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.	Oxygen	24-30	tumor necrosis factor	Mus musculus	69-90
8954292-0	1996	Effect of O2 availability on neuroendocrine variables at rest and during exercise: O2 breathing increases plasma prolactin.	Oxygen	10-12	prolactin	Homo sapiens	113-122
8769813-1	1996	We tested the hypothesis that gram-negative bacteremia (GNB) and brief (30 min) reductions in the hepatic O2 supply by low-flow ischemia differentially modulate tumor necrosis factor-alpha (TNF-alpha) gene expression owing to sequence-specific activation of cyclooxygenase vs. complement (C) pathways.	Oxygen	106-108	tumor necrosis factor	Homo sapiens	190-199
8769813-11	1996	These results identify a novel sequence-dependent interaction whereby hepatic O2 deprivation after GNB downregulates TNF-alpha via generation of cyclooxygenase metabolites, whereas ischemia preceding GNB increases cytokine expression via reactive O2 species but not C activation.	Oxygen	78-80	tumor necrosis factor	Homo sapiens	117-126
8561606-6	1996	RESULTS: After 30 minutes of reperfusion, the endothelin-1-treated hearts showed significantly reduced recovery of left ventricular systolic function (positive maximum dP/dt and volume normalized [V10] dP/dt) and diastolic function (negative maximum dP/dt), coronary blood flow, and myocardial oxygen consumption compared with the control group (p &lt; 0.05).	Oxygen	294-300	endothelin 1	Homo sapiens	46-58
8851897-5	1996	These changes of serum-EPO concentration were correlated to the changes in arterial blood oxygen saturation (r = -0.60, P = 0.0009), pH (r = 0.67, P = 0.003), and in-vivo venous blood oxygen half saturation tension (r = -0.68, P = 0.004) but not to the changes in 2, 3 diphosphoglycerate.	Oxygen	90-96	erythropoietin	Homo sapiens	23-26
8851897-5	1996	These changes of serum-EPO concentration were correlated to the changes in arterial blood oxygen saturation (r = -0.60, P = 0.0009), pH (r = 0.67, P = 0.003), and in-vivo venous blood oxygen half saturation tension (r = -0.68, P = 0.004) but not to the changes in 2, 3 diphosphoglycerate.	Oxygen	184-190	erythropoietin	Homo sapiens	23-26
8932447-3	1996	Our previous DSC study has suggested that SOD binding to dipalmitoylphosphatidylglycerol (DPPG) may protect lipid membranes against oxygen-mediated injury.	Oxygen	132-138	superoxide dismutase 1	Homo sapiens	42-45
8924621-11	1996	These spin adducts were attenuated by superoxide dismutase and catalase, implying that O2-.	Oxygen	87-89	catalase	Homo sapiens	63-71
8834159-1	1996	Oxygen-dependent changes of erythropoietin production in liver and kidneys provide the basis for a highly efficient feedback control of erythropoiesis.	Oxygen	0-6	erythropoietin	Homo sapiens	28-42
8954292-0	1996	Effect of O2 availability on neuroendocrine variables at rest and during exercise: O2 breathing increases plasma prolactin.	Oxygen	83-85	prolactin	Homo sapiens	113-122
8954296-1	1996	This study investigated the human erythropoietin (EPO) response to short-term hypocapnic hypoxia, its relationship to a normoxic or hypoxic increase of the haemoglobin oxygen affinity, and its suppression by the addition of CO2 to the hypoxic gas.	Oxygen	168-174	erythropoietin	Homo sapiens	34-48
8954296-1	1996	This study investigated the human erythropoietin (EPO) response to short-term hypocapnic hypoxia, its relationship to a normoxic or hypoxic increase of the haemoglobin oxygen affinity, and its suppression by the addition of CO2 to the hypoxic gas.	Oxygen	168-174	erythropoietin	Homo sapiens	50-53
8954296-9	1996	Among the measured blood gas and acid-base parameters, only the partial pressures of oxygen in arterial blood during hypocapnic hypoxia were related to the peak values of serum-EPO (r = -0.81, P = 0.01).	Oxygen	85-91	erythropoietin	Homo sapiens	177-180
8728025-5	1996	From the fact that the response to phorbol myristate acetate (PMA), as well as to formyl-methionyl-leucyl-phenylalanine (fMLP) was almost totally inhibited by superoxide dismutase (SOD), we conclude that O2.- is the reacting oxygen species measured.	Oxygen	204-206	formyl peptide receptor 1	Homo sapiens	121-125
8856983-6	1996	On the other hand, tumor sensitization may result from activation of "killing" proteins such as interleukin-1 beta converting enzyme (ICE) or other ICE-like proteases, possibly through TNF/LT-induced oxygen free radicals.	Oxygen	200-206	caspase 1	Homo sapiens	96-132
8856983-6	1996	On the other hand, tumor sensitization may result from activation of "killing" proteins such as interleukin-1 beta converting enzyme (ICE) or other ICE-like proteases, possibly through TNF/LT-induced oxygen free radicals.	Oxygen	200-206	caspase 1	Homo sapiens	134-137
8856983-6	1996	On the other hand, tumor sensitization may result from activation of "killing" proteins such as interleukin-1 beta converting enzyme (ICE) or other ICE-like proteases, possibly through TNF/LT-induced oxygen free radicals.	Oxygen	200-206	caspase 1	Homo sapiens	148-151
8856983-6	1996	On the other hand, tumor sensitization may result from activation of "killing" proteins such as interleukin-1 beta converting enzyme (ICE) or other ICE-like proteases, possibly through TNF/LT-induced oxygen free radicals.	Oxygen	200-206	tumor necrosis factor	Homo sapiens	185-188
8728025-5	1996	From the fact that the response to phorbol myristate acetate (PMA), as well as to formyl-methionyl-leucyl-phenylalanine (fMLP) was almost totally inhibited by superoxide dismutase (SOD), we conclude that O2.- is the reacting oxygen species measured.	Oxygen	225-231	formyl peptide receptor 1	Homo sapiens	121-125
9145335-1	1996	The differential expression of protein kinase C (PKC) isozymes and small GTP-binding proteins, and their relation to O2 generation and phospholipase D (PLD) activation were analyzed during the differentiation of human promyelocytic HL60 cells to neutrophil-like cells induced by either retinoic acid (RA) or dibutyryl cyclic AMP (dbcAMP).	Oxygen	117-119	protein kinase C alpha	Homo sapiens	49-52
8886800-5	1996	We conclude that while SOD may play a physiological role in maintaining a balance between O2.- and H2O2, high levels of this enzyme are associated with impaired sperm function because (a) the human spermatozoon is highly susceptible to the cytotoxic effects of H2O2, (b) O2.- is an important mediator of normal sperm function, and (c) high SOD activities reflect errors in spermatogenesis associated with germ cell exfoliation and the retention of excess residual cytoplasm by the spermatozoa.	Oxygen	90-92	superoxide dismutase 1	Homo sapiens	23-26
8886800-5	1996	We conclude that while SOD may play a physiological role in maintaining a balance between O2.- and H2O2, high levels of this enzyme are associated with impaired sperm function because (a) the human spermatozoon is highly susceptible to the cytotoxic effects of H2O2, (b) O2.- is an important mediator of normal sperm function, and (c) high SOD activities reflect errors in spermatogenesis associated with germ cell exfoliation and the retention of excess residual cytoplasm by the spermatozoa.	Oxygen	101-103	superoxide dismutase 1	Homo sapiens	23-26
8855453-1	1996	H2O2 and other reduced oxygen species have been proposed as activators of the transcription factor, NF Kappa B.	Oxygen	23-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-110
24202796-2	1996	The degree of regioselectivity of the PCB oxygen addition-induced dechlorination reaction was determined by measurement of the residual amount of label in the M-19 ions produced by addition of O2 and subsequent loss of OCl from the molecule.	Oxygen	42-48	pyruvate carboxylase	Homo sapiens	38-41
8857434-5	1996	INTERVENTIONS: The effect of dobutamine infusion (6 mu g kg-1 min-1) on systemic and regional oxygen transport was studied in ten patients, with six patients serving as controls.	Oxygen	94-100	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
8857434-11	1996	Systemic oxygen consumption increased in response to dobutamine (141 +/- 11 vs 149 +/- 11 ml x min-1 x m-2; P &lt;0.05) but did not change in the control group.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
24202796-2	1996	The degree of regioselectivity of the PCB oxygen addition-induced dechlorination reaction was determined by measurement of the residual amount of label in the M-19 ions produced by addition of O2 and subsequent loss of OCl from the molecule.	Oxygen	193-195	pyruvate carboxylase	Homo sapiens	38-41
8708936-2	1996	It is known that erythropoietin (EPO) increases when partial pressure of oxygen is insufficient for metabolic demand.	Oxygen	73-79	erythropoietin	Homo sapiens	17-31
8708936-2	1996	It is known that erythropoietin (EPO) increases when partial pressure of oxygen is insufficient for metabolic demand.	Oxygen	73-79	erythropoietin	Homo sapiens	33-36
8594307-3	1996	Purified rHuEpo (5-80 mU/ml) produced a significant increase above control levels of Epo in Hep3B cell cultures under normoxic (20% O2) conditions.	Oxygen	132-134	erythropoietin	Homo sapiens	12-15
8649194-1	1996	Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci.	Oxygen	93-99	metallothionein 1	Rattus norvegicus	56-73
8649194-1	1996	Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci.	Oxygen	93-99	metallothionein 1	Rattus norvegicus	75-77
10388012-2	1996	EPO is produced mainly by the kidneys, and transcription of the EPO gene is promoted by a reduction in the oxygen concentration in the blood.	Oxygen	107-113	erythropoietin	Homo sapiens	64-67
9499162-3	1996	An emerging hypothesis contends that A beta toxicity results from peptide-mediated free radical reactions and generation of reactive oxygen species.	Oxygen	133-139	amyloid beta precursor protein	Homo sapiens	37-43
8569707-3	1996	However, the specific involvement of the propranolol oxygen atoms in binding to the wild-type and T355N mutant 5-HT1D beta receptors has never been addressed experimentally.	Oxygen	53-59	5-hydroxytryptamine receptor 1B	Homo sapiens	111-122
10388012-44	1996	More specifically, the reason that athletes undergo training at high altitudes is to boost EPO production because of the lower oxygen partial pressure, and this brings about the desired effect of sustained athletic capability due to a resultant increase in red blood cells.	Oxygen	127-133	erythropoietin	Homo sapiens	91-94
8771201-1	1996	Protoporphyrinogen oxidase (E.C.1.3.3.4) catalyzes the oxygen-dependent oxidation of protoporphyrinogen IX to protoporphyrin IX.	Oxygen	55-61	protoporphyrinogen oxidase	Homo sapiens	0-26
9983043-0	1996	Oxygen dependence of the transport properties of Nd1.78Ce0.22CuO4+/- delta.	Oxygen	0-6	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	49-52
8746197-2	1995	The objective of this study was to test the hypothesis that constitutive nitric oxide synthase (cNOS) is sensitive to oxygen tension and that hypoxia increases the activity of cNOS and nitric oxide production in the porcine coronary microcirculation.	Oxygen	118-124	nitric oxide synthase 3	Homo sapiens	96-100
8746214-11	1995	CONCLUSIONS: Et-1 induction by hypoxia requires endothelial cell-specific factor(s) or steps, new protein synthesis, and may involve a haeme protein-containing pathway in oxygen sensing.	Oxygen	171-177	endothelin 1	Homo sapiens	13-17
8944422-5	1996	When compared to endotoxin-challenged untreated animals, C1I substitution significantly stabilized mean arterial pressure (p &lt; 0.01), increased central venous oxygen saturation (p &lt; 0.05), prevented the decrease of antithrombin III (p &lt; 0.05), and reduced fibrin deposition in the microcirculation of the liver and the lungs to approximately 30% of that observed in the untreated animals (p &lt; 0.01).	Oxygen	162-168	plasma protease C1 inhibitor	Oryctolagus cuniculus	57-60
8768334-1	1996	The data of long-standing research allowed to establish correlation between oxygen consumption different at various age and catecholamine (CA) content and acetylcholinesterase (AChE) activity in blood.	Oxygen	76-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	177-181
8560489-4	1995	Both cis-fatty acids inhibited a chemotactic peptide-, fMLP-induced production of reactive oxygen metabolites without affecting fMLP-induced elevation of intracellular calcium levels.	Oxygen	91-97	formyl peptide receptor 1	Homo sapiens	55-59
8746197-13	1995	CONCLUSIONS: These experiments demonstrated that the regulation of cNOS is sensitive to oxygen tension.	Oxygen	88-94	nitric oxide synthase 3	Homo sapiens	67-71
8586863-1	1995	In vitro activation of murine peritoneal macrophages by TNF and IL-I cytokines resulted in significant elevation of respiratory burst (toxic oxygen metabolites) in comparison to inactivated cells when challenged with Toxoplasma gondii.	Oxygen	141-147	tumor necrosis factor	Mus musculus	56-59
8974837-9	1995	The presence of an antioxidant enzyme, catalase, in oxygen-saturated PBS+ protected RPE cells against NUV killing, but superoxide dismutase did not protect the RPE cells against NUV killing.	Oxygen	52-58	catalase	Homo sapiens	39-47
8536713-10	1995	However, a p50-p65 heterodimer of NF-kappa B was rapidly and strongly activated when HeLa cells were re-exposed to normal oxygen pressure.	Oxygen	122-128	nuclear factor kappa B subunit 1	Homo sapiens	34-44
8675632-2	1995	To determine whether constitutive NO synthase (cNOS) is regulated by O2, we assessed cNOS expression and activity in bovine pulmonary artery endothelial cells exposed to different concentrations of O2.	Oxygen	69-71	nitric oxide synthase 3	Bos taurus	47-51
8675632-3	1995	In a time-dependent manner, changes in O2 concentration from 95 to 3% produced a progressive decrease in cNOS mRNA and protein levels resulting in 4.8- and 4.3-fold reductions after 24h, respectively.	Oxygen	39-41	nitric oxide synthase 3	Bos taurus	105-109
8675632-5	1995	Compared with 20% O2, cNOS activity was increased 1.5-fold in 95% O2 and decreased 1.9-fold in 3% O2.	Oxygen	18-20	nitric oxide synthase 3	Bos taurus	22-26
8536387-0	1995	Exposure to hyperbaric oxygen induces tumour necrosis factor-alpha (TNF-alpha) secretion from rat macrophages.	Oxygen	23-29	tumor necrosis factor	Rattus norvegicus	68-77
8536387-1	1995	We investigated the secretion of TNF-alpha by monocytes and macrophages derived from the peripheral blood, spleen, and lungs after a single exposure to a therapeutic profile of hyperbaric oxygen (HBO).	Oxygen	188-194	tumor necrosis factor	Rattus norvegicus	33-42
8536387-4	1995	Exposure to hyperbaric oxygen induced a significant increase in the spontaneous ex vivo secretion of TNF-alpha (without LPS) by mononuclear cells from the blood, spleen, and lung (P &lt; 0.05 from air controls).	Oxygen	23-29	tumor necrosis factor	Rattus norvegicus	101-110
8746845-6	1995	Oxygen pressure for half-maximum respiration, p50, in isolated mitochondria at state 4 was 0.025 kPa (0.2 Torr; 0.3 microM O2), whereas p50 in endothelial cells was 0.06-0.08 kPa (0.5 Torr).	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	46-49
8746845-6	1995	Oxygen pressure for half-maximum respiration, p50, in isolated mitochondria at state 4 was 0.025 kPa (0.2 Torr; 0.3 microM O2), whereas p50 in endothelial cells was 0.06-0.08 kPa (0.5 Torr).	Oxygen	123-125	nuclear factor kappa B subunit 1	Homo sapiens	46-49
8675632-5	1995	Compared with 20% O2, cNOS activity was increased 1.5-fold in 95% O2 and decreased 1.9-fold in 3% O2.	Oxygen	66-68	nitric oxide synthase 3	Bos taurus	22-26
8675632-5	1995	Compared with 20% O2, cNOS activity was increased 1.5-fold in 95% O2 and decreased 1.9-fold in 3% O2.	Oxygen	66-68	nitric oxide synthase 3	Bos taurus	22-26
8524640-2	1995	Subsequently HIF-1 activity has also been found in cell lines which do not express erythropoietin, suggesting that HIF-1 is part of a widespread oxygen sensing mechanism.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-18
8675632-6	1995	A decrease in O2 concentration from 94 to 3% shortened cNOS mRNA half-life from 46 to 24 h and caused a 20-fold repression of cNOS gene transcription.	Oxygen	14-16	nitric oxide synthase 3	Bos taurus	55-59
8675632-6	1995	A decrease in O2 concentration from 94 to 3% shortened cNOS mRNA half-life from 46 to 24 h and caused a 20-fold repression of cNOS gene transcription.	Oxygen	14-16	nitric oxide synthase 3	Bos taurus	126-130
8675632-8	1995	We conclude that O2 upregulates cNOS expression through transcriptional and post-transcriptional mechanisms.	Oxygen	17-19	nitric oxide synthase 3	Bos taurus	32-36
8675632-9	1995	A decrease in cNOS activity in the presence of low O2 levels, therefore, may contribute to hypoxia-induced vasoconstriction in the pulmonary circulation.	Oxygen	51-53	nitric oxide synthase 3	Bos taurus	14-18
8553307-4	1995	METHODS: Plasma levels of endothelin-1 were measured by specific radioimmunoassay in 10 control subjects at rest and following 30 minutes of acute hypoxaemia (SaO2 75-80%) induced by breathing a nitrogen/oxygen mixture, and in 10 patients with hypoxaemic cor pulmonale.	Oxygen	204-210	endothelin 1	Homo sapiens	26-38
7499331-5	1995	Quantitative reverse transcription-polymerase chain reaction analysis revealed that mRNAs coding for the secretory forms of vascular endothelial growth factor (VEGF), a mitogen specific to endothelial cells, were present in both endothelial cells and pericytes and that their levels increased significantly in the two cell types as the atmospheric O2 concentration decreased.	Oxygen	348-350	vascular endothelial growth factor A	Homo sapiens	124-158
7499331-5	1995	Quantitative reverse transcription-polymerase chain reaction analysis revealed that mRNAs coding for the secretory forms of vascular endothelial growth factor (VEGF), a mitogen specific to endothelial cells, were present in both endothelial cells and pericytes and that their levels increased significantly in the two cell types as the atmospheric O2 concentration decreased.	Oxygen	348-350	vascular endothelial growth factor A	Homo sapiens	160-164
8524640-2	1995	Subsequently HIF-1 activity has also been found in cell lines which do not express erythropoietin, suggesting that HIF-1 is part of a widespread oxygen sensing mechanism.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-120
8524640-3	1995	In electrophoretic mobility shift assays HIF-1 DNA binding activity is only detectable in nuclear extracts of cells cultivated in a low oxygen atmosphere.	Oxygen	136-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-46
8529674-2	1995	Recent studies on the induction of erythropoietin gene expression by hypoxia have indicated that erythropoietin forms part of a widely operative system of gene regulation by oxygen.	Oxygen	174-180	erythropoietin	Homo sapiens	35-49
7499198-1	1995	Nitric oxide synthase (NOS) catalyzes sequential NADPH- and O2-dependent mono-oxygenase reactions converting L-arginine to N omega-hydroxy-L-arginine and N omega-hydroxy-L-arginine to citrulline and nitric oxide.	Oxygen	60-62	nitric oxide synthase 2	Homo sapiens	0-21
8529674-2	1995	Recent studies on the induction of erythropoietin gene expression by hypoxia have indicated that erythropoietin forms part of a widely operative system of gene regulation by oxygen.	Oxygen	174-180	erythropoietin	Homo sapiens	97-111
7592968-4	1995	In this study, we provide evidence that the effect of okadaic acid on NF-kappa B activation is indirect and dependent on the production of reactive oxygen intermediates rather than the inhibition of an I kappa B-alpha phosphatase.	Oxygen	148-154	nuclear factor kappa B subunit 1	Homo sapiens	70-80
8590992-10	1995	Treatment with the beta 1-adrenoceptor antagonist, atenolol, in a dose of 80 mg kg-1 body weight abolished right ventricular hypertrophy in response to 7% inspired oxygen, without affecting haematocrit and caused a small reduction in the ratio of heart weight to body weight in normoxic rats.	Oxygen	164-170	adrenoceptor beta 1	Rattus norvegicus	19-38
8607310-6	1995	Oxygen transport capacity was investigated by calculation of p50 for oxygen by use of the oxygen status algorithm (OSA 2.0) programme and measurement of 2,3-diphosphoglycerate (2,3-DPG) concentrations.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	61-64
8607310-9	1995	P50 for oxygen (3.5 kPa) in shed mediastinal blood was not significantly different compared to patient blood, but significantly higher (P &lt; 0.01) compared with stored SAGM blood.	Oxygen	8-14	nuclear factor kappa B subunit 1	Homo sapiens	0-3
8688912-2	1995	Zymosan, phorbol ester and fluoride induced the formation and accumulation of oxygen radicals intra- and extracellularly, ionomycin and lipopolysaccharide led to an intracellular accumulation of oxygen radicals, while after arachidonic acid and tumor necrosis factor-alpha, no reactive oxygen species were formed.	Oxygen	78-84	tumor necrosis factor	Homo sapiens	245-272
8749844-5	1995	The generalized potential function allows atoms to sample a continuous parameter space that includes the Cartesian coordinates and their occupancy and type, e.g., the method allows change of an sp3 carbon into an sp2 carbon or oxygen.	Oxygen	227-233	Sp3 transcription factor	Homo sapiens	194-197
8555060-0	1995	Hb Arta [beta 45 (CD4) Phe-->Cys]: a new unstable haemoglobin with reduced oxygen affinity in trans with beta-thalassaemia.	Oxygen	75-81	CD4 molecule	Homo sapiens	18-21
7586450-3	1995	We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
7586450-3	1995	We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
7592416-2	1995	Under standard growth conditions, only the hemA gene is transcribed, and the level of ALA synthase activity varies in response to oxygen tension.	Oxygen	130-136	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	43-47
7591064-7	1995	Therefore, despite the multiplicity of the effects of GH on the immune system in vivo, its effects on human monocytes in vitro appear to be limited to priming for the release of reactive oxygen intermediates.	Oxygen	187-193	growth hormone 1	Homo sapiens	54-56
8537607-10	1995	The addition of superoxide dismutase and catalase to lymphocyte cultures reversed the inhibition of the proliferative response, implicating reactive species of oxygen as the causative agents of these alterations.	Oxygen	160-166	catalase	Rattus norvegicus	41-49
7592416-3	1995	The presence of an FNR consensus sequence upstream of hemA suggested that oxygen regulation of hemA expression could be mediated, in part, through a homolog of the fnr gene.	Oxygen	74-80	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	54-58
7592416-3	1995	The presence of an FNR consensus sequence upstream of hemA suggested that oxygen regulation of hemA expression could be mediated, in part, through a homolog of the fnr gene.	Oxygen	74-80	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	95-99
7592416-9	1995	On the other hand, the open reading frame immediately upstream of hemA appears to be an activator of hemA transcription regardless of either the presence or the absence of oxygen or FnrL.	Oxygen	172-178	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	66-70
7592416-10	1995	Given the lack of hemT expression under these conditions, we consider FnrL regulation of hemA expression to be a major factor in bringing about changes in the level of ALA synthase activity in response to changes in oxygen tension.	Oxygen	216-222	5-aminolevulinate synthase	Rhodobacter sphaeroides 2.4.1	89-93
8593536-3	1995	Molecular oxygen was found to play a predominant role in autoxidation of o-semiquinone during reduction of adrenochrome catalyzed by NADPH-cytochrome P450 reductase.	Oxygen	10-16	cytochrome p450 oxidoreductase	Homo sapiens	133-164
7595062-1	1995	Tumor necrosis factor (TNF) triggers cell spreading, release of granule constituents, and production of toxic oxygen derivatives in human neutrophils adherent to fibrinogen.	Oxygen	110-116	tumor necrosis factor	Homo sapiens	0-21
7595062-1	1995	Tumor necrosis factor (TNF) triggers cell spreading, release of granule constituents, and production of toxic oxygen derivatives in human neutrophils adherent to fibrinogen.	Oxygen	110-116	tumor necrosis factor	Homo sapiens	23-26
7595062-1	1995	Tumor necrosis factor (TNF) triggers cell spreading, release of granule constituents, and production of toxic oxygen derivatives in human neutrophils adherent to fibrinogen.	Oxygen	110-116	fibrinogen beta chain	Homo sapiens	162-172
7474002-10	1995	The enhanced NO3- formation may well result from NO reacting with oxygen-free radicals counteracting superoxide anion-induced destruction of tissue, thereby potentially functioning as a protectant molecule.	Oxygen	66-72	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
7578266-2	1995	These data demonstrated the key role of free radicals, which were likely, active oxygen species, in the synthesis of inducible NO-synthase (iNOS) responsible for the NO production in this organ.	Oxygen	81-87	nitric oxide synthase 2, inducible	Mus musculus	117-138
7578266-2	1995	These data demonstrated the key role of free radicals, which were likely, active oxygen species, in the synthesis of inducible NO-synthase (iNOS) responsible for the NO production in this organ.	Oxygen	81-87	nitric oxide synthase 2, inducible	Mus musculus	140-144
8547588-0	1995	beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer"s disease.	Oxygen	30-36	amyloid beta precursor protein	Homo sapiens	0-20
8547588-1	1995	beta-Amyloid (A beta), the central constituent of senile plaques in Alzheimer"s disease (AD) brains, was shown by us recently to generate free radicals in an oxygen dependent mechanism.	Oxygen	158-164	amyloid beta precursor protein	Homo sapiens	5-20
8547588-5	1995	These results support the hypothesis that A beta neurotoxicity in AD may be due in part to A beta-derived, oxygen-dependent free radical inhibition of glutamate uptake.	Oxygen	107-113	amyloid beta precursor protein	Homo sapiens	42-48
8547588-5	1995	These results support the hypothesis that A beta neurotoxicity in AD may be due in part to A beta-derived, oxygen-dependent free radical inhibition of glutamate uptake.	Oxygen	107-113	amyloid beta precursor protein	Homo sapiens	91-97
8551388-4	1995	In vitro cell culture experiments suggest that VEGF is upregulated by oxygen deprivation.	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	47-51
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Oxygen	146-152	tumor necrosis factor	Rattus norvegicus	48-75
7559551-0	1995	Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene.	Oxygen	35-37	tyrosine hydroxylase	Homo sapiens	66-86
7559551-8	1995	The present study was undertaken to further characterize the sequences that confer O2 responsiveness of the TH gene and to identify hypoxia-induced protein interactions with these sequences.	Oxygen	83-85	tyrosine hydroxylase	Homo sapiens	108-110
7546769-0	1995	Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages.	Oxygen	23-29	tumor necrosis factor	Mus musculus	65-86
7546769-4	1995	We demonstrated that conditions of anoxia (95% nitrogen/5% CO2) or hyperoxia (95% oxygen/5% CO2) independently resulted in the increased expression of both TNF and MIP-1 alpha mRNA and protein from lipopolysaccharide (LPS)-stimulated AMO, as compared with cells cultured in room air.	Oxygen	82-88	tumor necrosis factor	Mus musculus	156-159
7546769-5	1995	The specific culture condition of anoxia (x 6 h) followed by hyperoxia (x 18 h) produced the greatest increases in both TNF and MIP-1 alpha, suggesting that when following a period of anoxic priming, oxygen stress results in exaggerated cytokine production.	Oxygen	200-206	tumor necrosis factor	Mus musculus	120-123
7546769-8	1995	These findings suggested that alterations in ambient oxygen tension can regulate the expression of TNF and MIP-1 alpha from activated AMO, and that oxidant-related cytokine production may represent an important mechanism by which inflammation occurs in the clinical settings of ischemia-reperfusion injury and hyperoxia.	Oxygen	53-59	tumor necrosis factor	Mus musculus	99-102
8593536-9	1995	A marked difference in the inhibitory effect of superoxide dismutase on oxygen consumption during adrenochrome reduction catalyzed by NADPH-cytochrome P450 reductase and DT-diaphorase was also observed.	Oxygen	72-78	cytochrome p450 oxidoreductase	Homo sapiens	134-165
8593536-9	1995	A marked difference in the inhibitory effect of superoxide dismutase on oxygen consumption during adrenochrome reduction catalyzed by NADPH-cytochrome P450 reductase and DT-diaphorase was also observed.	Oxygen	72-78	NAD(P)H quinone dehydrogenase 1	Homo sapiens	170-183
7560103-0	1995	Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.	Oxygen	87-93	cytochrome P450 1A1	Ovis aries	11-29
8547550-11	1995	Venous ET-1 levels were significantly correlated with venous oxygen content, pH, PO2, oxygen saturation, base excess, blood sodium concentration, and potassium concentration.	Oxygen	61-67	endothelin 1	Homo sapiens	7-11
8547550-11	1995	Venous ET-1 levels were significantly correlated with venous oxygen content, pH, PO2, oxygen saturation, base excess, blood sodium concentration, and potassium concentration.	Oxygen	86-92	endothelin 1	Homo sapiens	7-11
7560103-0	1995	Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.	Oxygen	87-93	cytochrome P450 1A1	Ovis aries	31-37
7475172-14	1995	Contractile function improved in a dose-dependent manner, and oxygen-mediated damage could be avoided by mercaptopropionyl glycine/catalase treatment.	Oxygen	62-68	catalase	Homo sapiens	131-139
7561445-0	1995	Siggaard-Andersen algorithm-derived p50 parameters: perturbation by abnormal hemoglobin-oxygen affinity and acid-base disturbances.	Oxygen	88-94	nuclear factor kappa B subunit 1	Homo sapiens	36-39
7561445-1	1995	The p50 and derived indexes, calculated by using the Siggaard-Andersen algorithm from a single measurement of arterial blood gas tensions and hemoglobin-oxygen saturation, are used to assess tissue oxygen availability in critical illness.	Oxygen	153-159	nuclear factor kappa B subunit 1	Homo sapiens	4-7
7561445-1	1995	The p50 and derived indexes, calculated by using the Siggaard-Andersen algorithm from a single measurement of arterial blood gas tensions and hemoglobin-oxygen saturation, are used to assess tissue oxygen availability in critical illness.	Oxygen	198-204	nuclear factor kappa B subunit 1	Homo sapiens	4-7
7561445-8	1995	We conclude that Siggaard-Andersen p50 calculations may be misleading when there are disturbances of hemoglobin-oxygen affinity and acid-base balance, owing to changes in shape of the hemoglobin-dissociation curve.	Oxygen	112-118	nuclear factor kappa B subunit 1	Homo sapiens	35-38
8576937-6	1995	The improvement of the cardiac output index and high-energy phosphate levels of the HF rat by the ACE inhibitors was associated with the recovery of the mitochondrial oxygen consumption rate.	Oxygen	167-173	angiotensin I converting enzyme	Rattus norvegicus	98-101
8606853-13	1995	Exposure of rat pups to oxygen caused an increase in RAR beta mRNA (1.21 +/- 0.03).	Oxygen	24-30	retinoic acid receptor, beta	Rattus norvegicus	53-61
7565686-3	1995	Both oxygen and glucose deficiencies result in extension of the VEGF mRNA half-life in a protein synthesis-dependent manner.	Oxygen	5-11	vascular endothelial growth factor A	Homo sapiens	64-68
7565686-5	1995	Results showed that under nonstressed conditions, VEGF shares with the glucose transporter GLUT-1 a relatively short half-life (0.64 and 0.52 h, respectively), which is extended fourfold and more than eightfold, respectively, when cells are deprived of either oxygen or glucose.	Oxygen	260-266	vascular endothelial growth factor A	Homo sapiens	50-54
8606853-14	1995	DEX treatment again decreased RAR beta mRNA in both control (0.55 +/- 0.06) and oxygen-exposed pups (0.67 +/- 0.12).	Oxygen	80-86	retinoic acid receptor, beta	Rattus norvegicus	30-38
7545393-3	1995	Reactive oxygen intermediates act as second messengers in the activation of NF-kappa B.	Oxygen	9-15	nuclear factor kappa B subunit 1	Homo sapiens	76-86
7548176-9	1995	Exogenously-added PLA2 generated large quantities of free AA in control and fMLP-treated cells (462 +/- 122 and 2097 +/- 176 pmol/10(7) PMN, respectively); however, this did not induce O2-, nor did it augment the level of O2- stimulated by fMLP.	Oxygen	222-224	phospholipase A2 group IB	Homo sapiens	18-22
8562921-5	1995	A mechanism likely to contribute to hypoxia-mediated generation of cytokines, such as interleukin 6, is activation of the transcription factor NF-IL-6, which occurs in oxygen deprivation.	Oxygen	168-174	interleukin 6	Homo sapiens	86-99
7653805-6	1995	Oxygen consumption averaged 93 +/- 28 mL.min-1.m-2 in the normothermic patients and 43 +/- 10 mL.min-1.m-2 in the hypothermic group.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	41-46
7573534-10	1995	During 100% O2 inhalation, RSA changes were no longer significantly linked to RF and VT, and also the correlation of RSA with dRAP was reduced (P &lt; 0.05).	Oxygen	12-14	fizzy-related	Drosophila melanogaster	126-130
8537230-12	1995	Thus, low oxygen increases in vitro sensitivity to erythropoietin, colony numbers, and relative gamma-globin synthesis in normal and sickle cultures.	Oxygen	10-16	erythropoietin	Homo sapiens	51-65
7669567-3	1995	The effect of hypervolaemia on tumour vascular resistance was determined as well as the effect of ATII on oxygen metabolism.	Oxygen	106-112	angiotensinogen	Rattus norvegicus	98-102
8580482-7	1995	The results indicated that VIP has potent protective activity against injury of pulmonary vascular permeability and may be a physiological modulator of inflammatory damage to vascular endothelium associated with toxic oxygen metabolites.	Oxygen	218-224	vasoactive intestinal peptide	Rattus norvegicus	27-30
7545633-6	1995	The oxygen free radical scavengers, dimethylsulphoxide (0.2-0.4 M) and glutathione (2 x 10(-6)-10(-5) M) block the TNF alpha-mediated cytolysis of target cells in the absence of protein synthesis inhibitors, but not in the presence of EM or ACT-D.	Oxygen	4-10	tumor necrosis factor	Mus musculus	115-124
7665979-3	1995	CGS-21680 (10(-7) to 10(-6) mol/L) and DPMA (10(-8) to 10(-5) mol/L) also produced significant increases in medium levels of EPO in a cloned EPO-producing Hep3B hepatocellular carcinoma cell line after 18 hours of incubation in 1% O2.	Oxygen	231-233	erythropoietin	Homo sapiens	125-128
7474671-6	1995	By contrast, with higher urea concentrations (120 mM), measurements of P50 showed an increase in the hemoglobin affinity for oxygen (decrease in P50).	Oxygen	125-131	nuclear factor kappa B subunit 1	Homo sapiens	71-74
8558480-4	1995	In NB rats, breathing 12 or 8% O2 for 5 min induced a pattern of response comparable to that described in older rats (10-11 weeks old): an initial increase and secondary fall in minute volume (VE), a fall in arterial pressure (ABP), an increase in muscle vascular conductance, while cerebral blood flow (CBF) increased at the 1st minute in six animals and fell by the 5th minute in all animals.	Oxygen	31-33	glutamate receptor interacting protein 2	Rattus norvegicus	227-230
8558480-10	1995	However, 8-PT increased baseline VE and reduced ABP in 12% O2 and reduced the secondary decrease in VE and HR evoked by 8% O2, but had no effect on the fall in ABP, or change in muscle vascular conductance.	Oxygen	59-61	glutamate receptor interacting protein 2	Rattus norvegicus	48-51
8536105-1	1995	Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism.	Oxygen	100-106	interferon gamma	Homo sapiens	0-16
8536105-1	1995	Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism.	Oxygen	100-106	interferon gamma	Homo sapiens	18-27
8536105-1	1995	Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism.	Oxygen	217-223	interferon gamma	Homo sapiens	0-16
8536105-1	1995	Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism.	Oxygen	217-223	interferon gamma	Homo sapiens	18-27
8536105-8	1995	PMN oxygen metabolism, measured by flow cytometry as an accumulation of the fluorescent compound dichlorofluorescein, was in these experiments significantly primed by IFN-gamma, both at baseline and when stimulated with fMLP.	Oxygen	4-10	interferon gamma	Homo sapiens	167-176
8536105-8	1995	PMN oxygen metabolism, measured by flow cytometry as an accumulation of the fluorescent compound dichlorofluorescein, was in these experiments significantly primed by IFN-gamma, both at baseline and when stimulated with fMLP.	Oxygen	4-10	formyl peptide receptor 1	Homo sapiens	220-224
7474671-6	1995	By contrast, with higher urea concentrations (120 mM), measurements of P50 showed an increase in the hemoglobin affinity for oxygen (decrease in P50).	Oxygen	125-131	nuclear factor kappa B subunit 1	Homo sapiens	145-148
8748222-0	1995	Novel copper superoxide dismutase mimics and damage mediated by O2.-.	Oxygen	64-66	superoxide dismutase 1	Homo sapiens	13-33
7667305-3	1995	The alpha rENaC mRNA (3.7-kb transcript) increased 3-fold in ATII cell RNA isolated from rats exposed to 85% O2 for 7 days and 6-fold after 4 days of subsequent exposure to 100% O2.	Oxygen	109-111	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	10-15
7667305-3	1995	The alpha rENaC mRNA (3.7-kb transcript) increased 3-fold in ATII cell RNA isolated from rats exposed to 85% O2 for 7 days and 6-fold after 4 days of subsequent exposure to 100% O2.	Oxygen	178-180	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	10-15
7656977-2	1995	VEGF, a potent angiogenic factor, has been shown to be induced by low oxygen concentrations.	Oxygen	70-76	vascular endothelial growth factor A	Homo sapiens	0-32
7667254-0	1995	Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.	Oxygen	73-79	tumor necrosis factor	Homo sapiens	20-41
7544348-3	1995	It is synthesized in several different tissues from L-Arg and O2, using NADPH as an electron donor, by a family of heme-containing catalytically self-sufficient monooxygenases known as nitric oxide synthases (NOS).	Oxygen	62-64	nitric oxide synthase 2	Homo sapiens	185-207
7544096-1	1995	We investigated the role of oxygen free radicals in the modulation of glyceraldehyde-3-phosphate dehydrogenase binding to the erythrocyte membrane.	Oxygen	28-34	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	70-110
8748222-4	1995	The biological damage mediated by O2.- can be attenuated by a cytosolic copper- and zinc-containing enzyme known as superoxide dismutase (SOD).	Oxygen	34-36	superoxide dismutase 1	Homo sapiens	116-136
8748222-4	1995	The biological damage mediated by O2.- can be attenuated by a cytosolic copper- and zinc-containing enzyme known as superoxide dismutase (SOD).	Oxygen	34-36	superoxide dismutase 1	Homo sapiens	138-141
8748222-9	1995	Our studies suggest that these copper complexes act as mimics of SOD in a variety of O2.	Oxygen	85-87	superoxide dismutase 1	Homo sapiens	65-68
8591699-6	1995	Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects.	Oxygen	33-35	interferon gamma	Homo sapiens	173-189
7484029-9	1995	P50 for oxygen (3.6 and 3.6 kPa) and 2,3-DPG concentrations (5.3 and 5.1 mikromol/ml erythrocyte) in shed mediastinal blood (1h and 6h postoperatively) were not significantly different compared to patient-blood.	Oxygen	8-14	nuclear factor kappa B subunit 1	Homo sapiens	0-3
7645699-3	1995	The study demonstrated that not only can reliable capnographic tracings be obtained from a thin catheter placed in the unintubated airway, but the subject may also receive up to 6 l.min-1 of oxygen via the nasal route without interference with the accuracy of the measurements.	Oxygen	191-197	CD59 molecule (CD59 blood group)	Homo sapiens	182-187
7548442-0	1995	Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration.	Oxygen	127-133	vascular endothelial growth factor A	Homo sapiens	30-64
7548442-4	1995	Intracellular levels of VEGF in clone A or HCT-8 cells exposed to either air (21% O2) or the 0.01% O2 mixture respectively increased from about 73 to 1270, and 1.5 to 1180 pg/10(6) cells (about 17- and 80-fold increases).	Oxygen	82-84	vascular endothelial growth factor A	Homo sapiens	24-28
7548442-4	1995	Intracellular levels of VEGF in clone A or HCT-8 cells exposed to either air (21% O2) or the 0.01% O2 mixture respectively increased from about 73 to 1270, and 1.5 to 1180 pg/10(6) cells (about 17- and 80-fold increases).	Oxygen	99-101	vascular endothelial growth factor A	Homo sapiens	24-28
7548442-8	1995	Because cell proliferation and clonogenicity were also measured, it was possible to estimate the secretion rates of VEGF for both cell lines as a function of oxygen percentage.	Oxygen	158-164	vascular endothelial growth factor A	Homo sapiens	116-120
7484176-4	1995	The degree of partial restoration of HRpeak to more normal values within seconds of 60% O2 inhalation (range 5-35 beats min-1 HRpeak increase) was greatest in subjects with low HRpeak.	Oxygen	88-90	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
8591699-6	1995	Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects.	Oxygen	33-35	interferon gamma	Homo sapiens	191-200
8591699-7	1995	This study suggests that both, strict metabolic control and in vitro culture with IFN-gamma may improve the monocyte oxygen-dependent bactericidal mechanism in NIDDM patients.	Oxygen	117-123	interferon gamma	Homo sapiens	82-91
7631012-8	1995	Our finding that the ATX-70-dependent enhancement of the TMP-NO signal was highest at approximately 20% O2, in both N2/O2 and argon/O2 mixtures, and decreased with increasing oxygen concentration is not compatible with the singlet oxygen mechanism.	Oxygen	104-106	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-24
7653584-1	1995	Mitochondrial manganese-containing SOD (MnSOD) is located at the primary site of O2 metabolism, and its expression may be regulated by changes in O2 level.	Oxygen	81-83	superoxide dismutase 2, mitochondrial	Mus musculus	40-45
7653584-1	1995	Mitochondrial manganese-containing SOD (MnSOD) is located at the primary site of O2 metabolism, and its expression may be regulated by changes in O2 level.	Oxygen	146-148	superoxide dismutase 2, mitochondrial	Mus musculus	40-45
7649486-3	1995	We present a simple method for the differentiation between oxygen activating reactions in which neutrophil-derived myeloperoxidase is involved.	Oxygen	59-65	myeloperoxidase	Homo sapiens	115-130
8557963-7	1995	In study 2 the increments in plasma endothelin-1 were similar to those observed in study 1 and the changes again correlated with changes in oxygen saturation as well as with those in systolic pulmonary pressure.	Oxygen	140-146	endothelin 1	Homo sapiens	36-48
7564106-9	1995	Exposure of the cells to hypoxia (1% O2 for 16 to 24 hr) resulted in specific up-regulation of ET-1 but not ET-2 gene expression.	Oxygen	37-39	endothelin 1	Homo sapiens	95-99
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	Oxygen	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	Oxygen	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
7631012-8	1995	Our finding that the ATX-70-dependent enhancement of the TMP-NO signal was highest at approximately 20% O2, in both N2/O2 and argon/O2 mixtures, and decreased with increasing oxygen concentration is not compatible with the singlet oxygen mechanism.	Oxygen	119-121	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-24
7631012-8	1995	Our finding that the ATX-70-dependent enhancement of the TMP-NO signal was highest at approximately 20% O2, in both N2/O2 and argon/O2 mixtures, and decreased with increasing oxygen concentration is not compatible with the singlet oxygen mechanism.	Oxygen	119-121	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-24
7631012-8	1995	Our finding that the ATX-70-dependent enhancement of the TMP-NO signal was highest at approximately 20% O2, in both N2/O2 and argon/O2 mixtures, and decreased with increasing oxygen concentration is not compatible with the singlet oxygen mechanism.	Oxygen	175-181	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-24
7552762-6	1995	Several lines of evidence, including earlier animal studies as well as more recent human studies, favor the expression of submaximal and maximal oxygen uptake during running in terms of ml.kg-0.75.min-1 rather than as ml.kg-1.min-1.	Oxygen	145-151	CD59 molecule (CD59 blood group)	Homo sapiens	197-202
7481105-6	1995	Complete global cerebral ischemia resulted in a significant 3-fold increase in the sagittal sinus concentration of ET-1 (P &lt; 0.01) that was associated with a significant decrease in the sagittal sinus venous oxygen saturation (P &lt; 0.01); the arterial ET-1 concentration remained unchanged.	Oxygen	211-217	endothelin 1	Canis lupus familiaris	115-119
7540515-1	1995	Inducible nitric oxide synthase (iNOS) catalyzes the formation of nitric oxide (NO) from L-arginine and O2.	Oxygen	104-106	nitric oxide synthase 2	Rattus norvegicus	0-31
8575046-7	1995	The results indicated that VIP has potent protective activity against injury of pulmonary vascular permeability and may be a physiological modulator of inflammatory damage to vascular endothelium associated with toxic oxygen metabolites.	Oxygen	218-224	vasoactive intestinal peptide	Rattus norvegicus	27-30
7626069-1	1995	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix (bHLH)-PAS DNA-binding protein tightly regulated by cellular oxygen tension.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
7626069-1	1995	Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix (bHLH)-PAS DNA-binding protein tightly regulated by cellular oxygen tension.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
7601557-2	1995	Active oxygen inhibited growth, particularly of P- cells and increased poly ADPR transferase activity and PKC activity more significantly in P- cells.	Oxygen	7-13	protein kinase C alpha	Homo sapiens	106-109
7554772-5	1995	Pulmonary oxygen uptake increased from 209 +/- 11 to 267 +/- 13 ml min-1 in the patients and from 268 +/- 5 to 320 +/- 8 ml min-1 in the controls.	Oxygen	10-16	CD59 molecule (CD59 blood group)	Homo sapiens	67-72
7491278-9	1995	Model calculations show that with this relatively low DMb value, the intracellular oxygen supply can be improved only slightly.	Oxygen	83-89	RT1 class II, locus DMb	Rattus norvegicus	54-57
7599122-2	1995	It was found that the average geometry of D-xylose in the active site of wild-type aldose reductase is characterized by strong hydrogen bonds involving the reactive carbonyl oxygen of the substrate and both Tyr48 and His110.	Oxygen	174-180	aldo-keto reductase family 1 member B	Homo sapiens	83-99
7540515-1	1995	Inducible nitric oxide synthase (iNOS) catalyzes the formation of nitric oxide (NO) from L-arginine and O2.	Oxygen	104-106	nitric oxide synthase 2	Rattus norvegicus	33-37
7585153-4	1995	We now show that as a consequence of glycation, PHF-tau from AD and AGE-tau generate oxygen free radicals, thereby activating transcription via nuclear factor-kappa B, increasing amyloid beta-protein precursor and release of approximately 4 kD amyloid beta-peptides.	Oxygen	85-91	renin binding protein	Homo sapiens	68-71
7562428-17	1995	The binding of SOD to negatively charged lipids may account, at least in part, for its ability to protect lipid membranes against oxygen-mediated injury.	Oxygen	130-136	superoxide dismutase 1	Homo sapiens	15-18
7603037-2	1995	The development of this tolerance to oxygen toxicity is associated with an increase in total pulmonary content of both CuZn and Mn superoxide dismutases (SOD).	Oxygen	37-43	superoxide dismutase 1	Rattus norvegicus	154-157
7603037-9	1995	After 7 or 14 days of exposure to 85% O2, the total lung content of CuZnSOD was increased because of cell hyperplasia and hypertrophy, but the intracellular concentrations of CuZnSOD did not increase.	Oxygen	38-40	superoxide dismutase 1	Rattus norvegicus	68-75
7603037-9	1995	After 7 or 14 days of exposure to 85% O2, the total lung content of CuZnSOD was increased because of cell hyperplasia and hypertrophy, but the intracellular concentrations of CuZnSOD did not increase.	Oxygen	38-40	superoxide dismutase 1	Rattus norvegicus	175-182
8525116-3	1995	Elucidating the oxygen sensitive enhancer elements of the erythropoietin gene has prompted studies on other oxygen-regulated genes.	Oxygen	16-22	erythropoietin	Homo sapiens	58-72
21597794-11	1995	Oxygen consumption rates (QO(2)) of Rat1-T1 and MR1 cells were significantly less than those of Rat1 and M1 fibroblasts and showed different changes as a function of time in monolayer culture.	Oxygen	0-6	major histocompatibility complex, class I-related	Rattus norvegicus	48-51
7478799-7	1995	During hypoxia, this group exhibited insulin-related sustained increases in the combined ventricular output and fetal body blood flow, accentuation of the prior insulin-related increase in blood flow to the heart, decreased systemic oxygen delivery, accentuation of the insulin-related increased oxygen extraction, reductions in the insulin-related increased systemic oxygen uptake, sustained increases in regional oxygen delivery to the heart and adrenal glands, reductions in the insulin-related increased delivery to the carcass, and decreased oxygen delivery to the kidneys and gastrointestinal tract.	Oxygen	296-302	insulin	Homo sapiens	37-44
7478799-7	1995	During hypoxia, this group exhibited insulin-related sustained increases in the combined ventricular output and fetal body blood flow, accentuation of the prior insulin-related increase in blood flow to the heart, decreased systemic oxygen delivery, accentuation of the insulin-related increased oxygen extraction, reductions in the insulin-related increased systemic oxygen uptake, sustained increases in regional oxygen delivery to the heart and adrenal glands, reductions in the insulin-related increased delivery to the carcass, and decreased oxygen delivery to the kidneys and gastrointestinal tract.	Oxygen	296-302	insulin	Homo sapiens	37-44
7478799-7	1995	During hypoxia, this group exhibited insulin-related sustained increases in the combined ventricular output and fetal body blood flow, accentuation of the prior insulin-related increase in blood flow to the heart, decreased systemic oxygen delivery, accentuation of the insulin-related increased oxygen extraction, reductions in the insulin-related increased systemic oxygen uptake, sustained increases in regional oxygen delivery to the heart and adrenal glands, reductions in the insulin-related increased delivery to the carcass, and decreased oxygen delivery to the kidneys and gastrointestinal tract.	Oxygen	296-302	insulin	Homo sapiens	37-44
7478799-7	1995	During hypoxia, this group exhibited insulin-related sustained increases in the combined ventricular output and fetal body blood flow, accentuation of the prior insulin-related increase in blood flow to the heart, decreased systemic oxygen delivery, accentuation of the insulin-related increased oxygen extraction, reductions in the insulin-related increased systemic oxygen uptake, sustained increases in regional oxygen delivery to the heart and adrenal glands, reductions in the insulin-related increased delivery to the carcass, and decreased oxygen delivery to the kidneys and gastrointestinal tract.	Oxygen	296-302	insulin	Homo sapiens	37-44
8525116-3	1995	Elucidating the oxygen sensitive enhancer elements of the erythropoietin gene has prompted studies on other oxygen-regulated genes.	Oxygen	108-114	erythropoietin	Homo sapiens	58-72
7552353-8	1995	We conclude that: (1) there are marked differences in the magnitude and trajectory of membrane depolarization between XII and NCX neurons in response to O2 deprivation, with NCX neurons showing a much longer latency to AD during anoxia than XII; and (2), when exposed to periods of anoxia of similar duration and severity, XII neurons are less likely to recover than NCX neurons and XII neurons may, therefore, be inherently more vulnerable to anoxia-induced injury than NCX neurons.	Oxygen	153-155	solute carrier family 8 member A1	Rattus norvegicus	126-129
7495099-4	1995	Both maximal oxygen uptake and endurance capacity are increased after EPO treatment in healthy subjects (4).	Oxygen	13-19	erythropoietin	Homo sapiens	70-73
7552353-8	1995	We conclude that: (1) there are marked differences in the magnitude and trajectory of membrane depolarization between XII and NCX neurons in response to O2 deprivation, with NCX neurons showing a much longer latency to AD during anoxia than XII; and (2), when exposed to periods of anoxia of similar duration and severity, XII neurons are less likely to recover than NCX neurons and XII neurons may, therefore, be inherently more vulnerable to anoxia-induced injury than NCX neurons.	Oxygen	153-155	solute carrier family 8 member A1	Rattus norvegicus	174-177
7552353-8	1995	We conclude that: (1) there are marked differences in the magnitude and trajectory of membrane depolarization between XII and NCX neurons in response to O2 deprivation, with NCX neurons showing a much longer latency to AD during anoxia than XII; and (2), when exposed to periods of anoxia of similar duration and severity, XII neurons are less likely to recover than NCX neurons and XII neurons may, therefore, be inherently more vulnerable to anoxia-induced injury than NCX neurons.	Oxygen	153-155	solute carrier family 8 member A1	Rattus norvegicus	174-177
7552353-8	1995	We conclude that: (1) there are marked differences in the magnitude and trajectory of membrane depolarization between XII and NCX neurons in response to O2 deprivation, with NCX neurons showing a much longer latency to AD during anoxia than XII; and (2), when exposed to periods of anoxia of similar duration and severity, XII neurons are less likely to recover than NCX neurons and XII neurons may, therefore, be inherently more vulnerable to anoxia-induced injury than NCX neurons.	Oxygen	153-155	solute carrier family 8 member A1	Rattus norvegicus	174-177
7779792-0	1995	Control of electron delivery to the oxygen reduction site of cytochrome c oxidase: a role for protons.	Oxygen	36-42	cytochrome c, somatic	Homo sapiens	61-73
7572222-5	1995	Endurance training resulted in a significant increase in maximal oxygen uptake (L min-1) (P &lt; 0.01).	Oxygen	65-71	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
7541940-1	1995	Recent work has indicated that oxygen-sensing mechanism(s) resembling those controlling erythropoietin production operate in many non-erythropoietin-producing cells.	Oxygen	31-37	erythropoietin	Homo sapiens	88-102
7541940-1	1995	Recent work has indicated that oxygen-sensing mechanism(s) resembling those controlling erythropoietin production operate in many non-erythropoietin-producing cells.	Oxygen	31-37	erythropoietin	Homo sapiens	134-148
7541940-2	1995	To pursue the implication that such a system might control other genes, we studied oxygen-regulated expression of mRNAs for vascular endothelial growth factor, platelet-derived growth factor (PDGF) A and B chains, placental growth factor (PLGF), and transforming growth factor in four different cell lines and compared the characteristics with those of erythropoietin regulation.	Oxygen	83-89	vascular endothelial growth factor A	Homo sapiens	124-158
7541940-6	1995	These similarities with established characteristics of erythropoietin regulation indicate that a similar mechanism of oxygen sensing is operating on a variety of vascular growth factors, and they suggest that chelatable iron is closely involved in the mechanism.	Oxygen	118-124	erythropoietin	Homo sapiens	55-69
7767532-6	1995	After the exposure to 10.5% oxygen, during which oxygen saturations were between 80 and 85%, the healthy subjects and those with OSAS developed increases in EPO of 34 and 49%, respectively, 240 min after the initiation of exposure (p &lt; 0.05).	Oxygen	28-34	erythropoietin	Homo sapiens	157-160
24178812-4	1995	The mixtures maintained the same molar ratio as in the native protein, and were selected just in order to throw into relief the preferential amino acids that were being photooxidized at both pH values.Under work conditions Lyso was only photooxidizable at pH 7, whereas the opposite accounted for the denatured protein: only measurable oxygen consumption was detected at pH 11.	Oxygen	336-342	lysozyme	Homo sapiens	223-227
24178812-5	1995	Nevertheless, Lyso at pH 11, evidenced an important physical quenching of O2((1)Deltag) due to the Tyr and Trp residues.The results for the native protein were interpreted on the basis of a previously described dark complex Eosin-Lyso, which selectively favours the photooxidation of the bounded protein.	Oxygen	74-76	lysozyme	Homo sapiens	14-18
7772042-7	1995	Thus it is likely that hydrogen-bonding of the enzyme to substituents containing oxygen or nitrogen increases the binding affinity of the hydrazides and enhances their oxidation by myeloperoxidase.	Oxygen	81-87	myeloperoxidase	Homo sapiens	181-196
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-11
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	148-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
7539918-0	1995	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
7539918-1	1995	Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.	Oxygen	86-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
7539918-1	1995	Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.	Oxygen	86-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
7539918-1	1995	Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.	Oxygen	86-88	erythropoietin	Homo sapiens	161-175
7628865-1	1995	Poly(ADPR) polymerase (PARP; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical-induced DNA strand breaks, transfers ADP ribose units to nuclear proteins and initiates apoptosis by depletion of cellular NAD and ATP pools.	Oxygen	88-94	poly(ADP-ribose) polymerase 1	Homo sapiens	23-27
7781369-11	1995	Gas exchange rates averaged 50.4 +/- 15.8 mL.min-1 for carbon dioxide and 71.1 +/- 20.2 mL.min-1 for oxygen.	Oxygen	101-107	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
8586256-7	1995	Of all oxygen containing derivatives diamantane 1,6-dicarboxylic acid dimethylester only exhibited a pronounced ligand interaction with cytochrome P-450.	Oxygen	7-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	136-152
7766614-1	1995	The binding of substrate/product or transition-state intermediates modifies the properties of medium-chain fatty acyl-CoA dehydrogenase (MCAD) by causing the redox potential to shift positive and the oxygen reactivity to slow by 3000-fold.	Oxygen	200-206	acyl-CoA dehydrogenase medium chain	Homo sapiens	94-135
7665432-9	1995	ET-1 levels rose approximately twofold in the control exercise (P &lt; 0.01) and in another group of seven subjects performing 1 h of exercise at 70% of peak oxygen uptake (P &lt; 0.001).	Oxygen	158-164	endothelin 1	Homo sapiens	0-4
7651752-5	1995	We report here that maternal hypoxia (11-13% O2) leads to 2-3-fold increases (p &lt; 0.01) in fetal adrenal TH, DBH, and NPY mRNA levels on the day before birth.	Oxygen	45-47	neuropeptide Y	Rattus norvegicus	121-124
7603852-1	1995	Dietary cells and the vitamins B12 and folate are necessary for the production of the red blood cells (erythrocytes), which carry oxygen from the lungs to the tissues and carbon dioxide from tissues to lungs.	Oxygen	130-136	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
7766614-1	1995	The binding of substrate/product or transition-state intermediates modifies the properties of medium-chain fatty acyl-CoA dehydrogenase (MCAD) by causing the redox potential to shift positive and the oxygen reactivity to slow by 3000-fold.	Oxygen	200-206	acyl-CoA dehydrogenase medium chain	Homo sapiens	137-141
7538678-5	1995	Possible involvement of a heme-containing oxygen sensor in MP elaboration of growth factors was suggested by the induction of bFGF and PDGF by normoxic MPs exposed to nickel or cobalt, although metabolic inhibitors such as sodium azide were without effect.	Oxygen	42-48	fibroblast growth factor 2	Homo sapiens	126-130
7744808-7	1995	These antagonists also inhibited the phosphorylation of p47-phox (about 50%) and O2.- release (about 80%) in cells stimulated with fMLP, but not with 4 beta-phorbol 12-myristate 13-acetate.	Oxygen	81-83	formyl peptide receptor 1	Homo sapiens	131-135
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Oxygen	187-194	growth factor receptor bound protein 2	Homo sapiens	45-49
7750578-4	1995	At an elevated concentration 7,8-dihydroneopterin was found to superinduce TNF alpha mediated programmed cell death due to the formation of reactive oxygen intermediates.	Oxygen	149-155	tumor necrosis factor	Homo sapiens	75-84
7762057-1	1995	Vasoactive intestinal peptide (VIP) is a known pulmonary and bronchial vasodilator as well as an oxygen free radical scavenger.	Oxygen	97-103	vasoactive intestinal peptide	Rattus norvegicus	31-34
7762057-8	1995	The addition of VIP to UW solution maintained the functional capacity of the lungs, recorded by lung resistance, lung compliance, elastic work, flow resistive work, shunt fraction, and blood oxygen tension.	Oxygen	191-197	vasoactive intestinal peptide	Rattus norvegicus	16-19
7762683-3	1995	SP-B mRNA levels were unaffected by O2, whereas SP-C mRNA levels were increased by 85, 102, and 115% in atmospheres of 35, 50, and 70% O2, respectively.	Oxygen	135-137	surfactant protein C	Homo sapiens	48-52
7766663-1	1995	Activation of glycogen synthase (GS) by insulin in isolated, aerated muscle was abolished when oxygen was replaced by nitrogen.	Oxygen	95-101	insulin	Homo sapiens	40-47
7771582-3	1995	Norepinephrine (NE, 25 nM-2.5 microM) and vasopressin (VP, 10 nM-0.1 microM) each increased perfusion pressure, oxygen consumption (VO2), and lactate and glycerol efflux of the perfused hindlimb.	Oxygen	112-118	arginine vasopressin	Rattus norvegicus	42-53
7748039-4	1995	The authors previously have demonstrated that pretreatment with cytokines such as IL-1 or TNF can reduce the lethality of endotoxin (lipopolysaccharide), gram-negative sepsis, cancer cachexia, and oxygen toxicity.	Oxygen	197-203	tumor necrosis factor	Mus musculus	90-93
7771804-6	1995	In the out--&gt;in electron transport pathway the components involved appear to be cytosolic reduced substrates--&gt;NADH produced by cytosolic dehydrogenases activity--&gt;NADH-cytochrome b5 oxidoreductase complex leaning out the external side of the external membrane--&gt;exogenous cytochrome c--&gt;cytochrome oxidase of contact sites--&gt;molecular oxygen.	Oxygen	354-360	cytochrome c, somatic	Homo sapiens	285-297
7762668-7	1995	The results indicate that the immunoregulatory lymphokine IFN-gamma primes the FMLP-stimulated cytotoxic activity of PMNs via the increased generation of reactive oxygen metabolites and indicate that cytotoxicity may require effector-target cell adherence.	Oxygen	163-169	interferon gamma	Oryctolagus cuniculus	58-67
7762684-0	1995	Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung.	Oxygen	62-68	interleukin-8	Oryctolagus cuniculus	0-13
7762684-2	1995	We hypothesized that IL-8 and MCP-1 mRNA expression in alveolar macrophages (AM) lavaged from rabbit lung would be increased by oxygen exposure, which is known to induce inflammation.	Oxygen	128-134	interleukin-8	Oryctolagus cuniculus	21-25
7762684-5	1995	Quantitative in situ hybridization with 3H-labeled cRNA probes showed both IL-8 and MCP-1 mRNA expression in AM during oxygen exposure, with peak levels of IL-8 mRNA at 56-h oxygen exposure and of MCP-1 mRNA at 64-h oxygen exposure with 24-h room air recovery.	Oxygen	119-125	interleukin-8	Oryctolagus cuniculus	75-79
7762684-6	1995	IL-8 mRNA was present in PMN between 48-h oxygen exposure and 64-h oxygen exposure with 24-h room air recovery.	Oxygen	42-48	interleukin-8	Oryctolagus cuniculus	0-4
7762684-6	1995	IL-8 mRNA was present in PMN between 48-h oxygen exposure and 64-h oxygen exposure with 24-h room air recovery.	Oxygen	67-73	interleukin-8	Oryctolagus cuniculus	0-4
7601550-8	1995	Oxygen radical scavengers, such as superoxide dismutase and catalase, may help to reduce the cold induced injury but their action is limited due to the inability readily to cross the plasma membrane.	Oxygen	0-6	catalase	Homo sapiens	60-68
7588904-2	1995	In 250 patients who underwent left and right heart catheterization, the oxygen consumption VO2 (ml.min-1) was calculated using Fick"s principle.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	99-104
7789421-0	1995	Oxygen modulates production of bFGF and TGF-beta by retinal cells in vitro.	Oxygen	0-6	fibroblast growth factor 2	Homo sapiens	31-35
7536895-0	1995	Programmed cell death and Bcl-2 protection in very low oxygen.	Oxygen	55-61	BCL2 apoptosis regulator	Homo sapiens	26-31
7723826-3	1995	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia), which drastically decreases the net formation of oxygen free radicals and does not increase oxidized lipid, protein or DNA.	Oxygen	80-86	BCL2 apoptosis regulator	Homo sapiens	53-58
7723826-3	1995	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia), which drastically decreases the net formation of oxygen free radicals and does not increase oxidized lipid, protein or DNA.	Oxygen	80-86	BCL2 apoptosis regulator	Homo sapiens	116-121
7723826-3	1995	Although a mechanism has been proposed that involves Bcl-2 activity on reactive oxygen species (ROS), expression of Bcl-2 or Bcl-xL prevents cell death induced by withdrawal of oxygen (hypoxia), which drastically decreases the net formation of oxygen free radicals and does not increase oxidized lipid, protein or DNA.	Oxygen	80-86	BCL2 like 1	Homo sapiens	125-131
7718584-0	1995	Oxygen equilibrium properties of nickel(II)-iron(II) hybrid hemoglobins cross-linked between 82 beta 1 and 82 beta 2 lysyl residues by bis(3,5-dibromosalicyl)fumarate: determination of the first two-step microscopic Adair constants for human hemoglobin.	Oxygen	0-6	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	96-116
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P &lt; 0.05).	Oxygen	34-40	interleukin 1 beta	Mus musculus	116-125
7789421-0	1995	Oxygen modulates production of bFGF and TGF-beta by retinal cells in vitro.	Oxygen	0-6	transforming growth factor beta 1	Homo sapiens	40-48
7790027-4	1995	Deferoxamine (a ferric iron chelator) and dithiothreitol (a sulfhydryl reagent) both prevented DNA damage and cell killing, indicate that hydroxyl radicals generated from O2- and H2O2 produced by the mitochondria in a process catalysed by iron contributed to DNA damage and that this pathway may be involved in TNF-alpha-induced cytotoxicity.	Oxygen	171-173	tumor necrosis factor	Mus musculus	311-320
7728836-5	1995	The regulation of the expression of the erythropoietin gene in relation to oxygen tension was investigated.	Oxygen	75-81	erythropoietin	Homo sapiens	40-54
7543674-10	1995	VEGF production is one mechanism through which oxygen supply may influence placental development.	Oxygen	47-53	vascular endothelial growth factor A	Homo sapiens	0-4
12228427-3	1995	nodules during rapid and gradual changes in temperature from 20[deg]C to either 15 or 25[deg]C. The affinity of leghemoglobin for O2 was also measured at each temperature and the values were used to calculate the infected cell O2 concentration (Oi).	Oxygen	130-132	leghemoglobin A	Glycine max	112-125
7893672-3	1995	265, 18289] complexed with human alpha-thrombin shows the boron atom covalently bonded to the side-chain oxygen of the active site serine, Ser195.	Oxygen	105-111	coagulation factor II, thrombin	Homo sapiens	39-47
7890721-2	1995	Differentiated HL-60 cells acquire responsiveness to fMet-Leu-Phe (fMLP), which activates phospholipase C and O2- generation in a pertussis toxin-sensitive manner.	Oxygen	110-112	formyl peptide receptor 1	Homo sapiens	67-71
7613035-2	1995	Manganese superoxide dismutase (Mn-SOD) plays a major role in the protection of the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species.	Oxygen	165-171	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
7613035-2	1995	Manganese superoxide dismutase (Mn-SOD) plays a major role in the protection of the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species.	Oxygen	165-171	superoxide dismutase 2, mitochondrial	Mus musculus	32-38
7633332-7	1995	It is concluded that under conditions which provide adequate oxygen and glucose, adenosine kinase plays a much greater role than adenosine deaminase in regulating the extracellular concentration of adenosine.	Oxygen	61-67	adenosine kinase	Rattus norvegicus	81-97
7706272-5	1995	Stoichiometric equivalent increases of AdK-catalyzed phosphotransfer and anaerobic ATP production also occurred up to more than 20-fold when oxidative phosphorylation was impaired by either O2 deprivation or treatment with KCN or p-(trifluoromethoxy)-phenylhydrazone.	Oxygen	190-192	adenosine kinase	Rattus norvegicus	39-42
7706272-8	1995	Increased AdK-catalyzed phosphotransfer paired with the apparent compensatory increase in ATP generation by anaerobic glycolysis in oxygen-deprived muscle occurred coincident with diminished rates of CK-catalyzed phosphoryl transfer indicative of a pairing between oxidatively produced ATP and CK-catalyzed phosphotransfer.	Oxygen	132-138	adenosine kinase	Rattus norvegicus	10-13
7728836-6	1995	The biochemical mechanism is sought which transmits the oxygen tension to transcription signals and the stability of erythropoietin mRNA.	Oxygen	56-62	erythropoietin	Homo sapiens	117-131
7900827-5	1995	Nuclear runoff assays confirmed increased transcription of both bFGF and flg genes in response to 85% O2, whereas increased translation at 6 days of exposure was confirmed by protein immunoanalysis.	Oxygen	102-104	filaggrin	Rattus norvegicus	73-76
7876246-1	1995	Myeloperoxidase (MPO), a lysosomal heme protein found exclusively in neutrophils and monocytes, is necessary for efficient oxygen-dependent microbicidal activity.	Oxygen	123-129	myeloperoxidase	Homo sapiens	0-15
7876246-1	1995	Myeloperoxidase (MPO), a lysosomal heme protein found exclusively in neutrophils and monocytes, is necessary for efficient oxygen-dependent microbicidal activity.	Oxygen	123-129	myeloperoxidase	Homo sapiens	17-20
7866984-6	1995	Endocytosis and subsequent localization around and in the cell nucleus of the BSA-insulin-chlorin e6 conjugate could be visualized using both FITC-labeled conjugate and 2",7"-dichlorofluorescin diacetate, a fluorescent indicator of the production of active oxygen species due to chlorin e6 activation.	Oxygen	257-263	insulin	Homo sapiens	82-89
7741258-0	1995	The role of iron chelators and oxygen in the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P450 oxidoreductase-dependent chromium(VI) reduction.	Oxygen	31-37	cytochrome p450 oxidoreductase	Homo sapiens	97-127
7741258-7	1995	Addition of superoxide dismutase and catalase, which both regenerate some O2, led to inhibition of CrVI reduction.	Oxygen	74-76	catalase	Homo sapiens	37-45
7873193-2	1995	TNF-alpha has been implicated in several forms of lung injury including that associated with oxygen toxicity.	Oxygen	93-99	tumor necrosis factor	Homo sapiens	0-9
7873193-3	1995	To investigate whether oxygen could induce or augment the release of TNF from AM, we acquired AM from nonsmoking volunteers and determined TNF release after in vitro hyperoxia.	Oxygen	23-29	tumor necrosis factor	Homo sapiens	69-72
7703349-1	1995	Cytochrome c is responsible for over 90% of the dioxygen consumption in the living cell and contributes to the build-up of a proton electrochemical gradient derived by the vectorial transfer of electrons between cytochrome c and molecular oxygen.	Oxygen	48-56	cytochrome c, somatic	Homo sapiens	0-12
7703349-1	1995	Cytochrome c is responsible for over 90% of the dioxygen consumption in the living cell and contributes to the build-up of a proton electrochemical gradient derived by the vectorial transfer of electrons between cytochrome c and molecular oxygen.	Oxygen	48-56	cytochrome c, somatic	Homo sapiens	212-224
7628659-0	1995	[Regulation of oxygen metabolism in human blood leukocytes by C-reactive protein].	Oxygen	15-21	C-reactive protein	Homo sapiens	62-80
7883956-4	1995	We found that injection of recombinant human TNF into the cisterna magna in the rabbit led to an acute reduction in cerebral oxygen uptake and a more prolonged reduction in cerebral blood flow.	Oxygen	125-131	tumor necrosis factor	Homo sapiens	45-48
7757199-0	1995	The loss of in vivo activity of recombinant human erythropoietin by active oxygen species.	Oxygen	75-81	erythropoietin	Homo sapiens	50-64
7757199-1	1995	The effects of active oxygen species on the in vivo activity of recombinant human erythropoietin (EPO) treated by Fenton system, xanthine (X) plus xanthine oxidase (XO) system and hydrogen peroxide (H2O2) has been studied by means of counting the increase in number of hemolyser-resistant cells (HRCs) in EPO-injected mice.	Oxygen	22-28	erythropoietin	Homo sapiens	82-96
7757199-4	1995	Electrophoretic studies on the structure of EPO revealed that its main protein band on sodium dodecyl sulfate-polyacrylamide gel (SDS-PAGE) disappeared in proportion with the extent of exposure to active oxygen generating systems.	Oxygen	204-210	erythropoietin	Homo sapiens	44-47
7757199-6	1995	This showed that aromatic groups in EPO were sensitive to attack by active oxygen species.	Oxygen	75-81	erythropoietin	Homo sapiens	36-39
7757199-7	1995	These results provide evidence that hydroxyl radical and other active oxygen species have a potential to react with EPO, leading to a reduction of its in vivo activity.	Oxygen	70-76	erythropoietin	Homo sapiens	116-119
7779457-2	1995	A new specific protein kinase C (PKC) inhibitor, Ro 31-7549, was used to explore the mechanisms by which particulate stimuli, quartz and chrysotile, stimulate human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM).	Oxygen	221-227	proline rich transmembrane protein 2	Homo sapiens	33-36
7752579-9	1995	At the end of the experiment, elevated plasma renin activity and pCO2, significantly decreased creatinine clearance, blood pH, pO2, base excess, HCO3-, oxygen saturation (P &lt; 0.01), a distinct glomerular proteinuria, and a final anuria were observated.	Oxygen	152-158	PCO2	Sus scrofa	65-69
7864832-20	1995	The striking contrast between DBM and cytochrome P-450, which carries out both epoxidation and allylic oxidation with non-conjugated olefinic substrates, is probably a reflection of the differences in redox potential of the activated oxygen species operative for these two enzymes.	Oxygen	234-240	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-54
7857927-9	1995	The main enzymatic differences between BCAD and MCAD are their substrate specificities and the significant oxygen reactivity exhibited by BCAD but not by MCAD.	Oxygen	107-113	acyl-CoA dehydrogenase medium chain	Sus scrofa	48-52
7620830-1	1995	In the present study, we examined whether active oxygen formed in the process of 4-nitroquinoline 1-oxide (4NQO) reduction by DT-diaphorase could induce oxidative stress on the pulmonary nuclei.	Oxygen	49-55	NAD(P)H quinone dehydrogenase 1	Homo sapiens	126-139
7710018-5	1995	Intratracheal jet-ventilation (rate: 20 breath.min-1) was with 100% oxygen.	Oxygen	68-74	CD59 molecule (CD59 blood group)	Homo sapiens	47-52
7599248-2	1995	The gene for the Cu/Zn superoxide dismutase enzyme (SOD-1), a key enzyme in the metabolism of oxygen free radicals, is located on the distal portion of chromosome 21.	Oxygen	94-100	superoxide dismutase 1	Homo sapiens	17-43
7599248-2	1995	The gene for the Cu/Zn superoxide dismutase enzyme (SOD-1), a key enzyme in the metabolism of oxygen free radicals, is located on the distal portion of chromosome 21.	Oxygen	94-100	superoxide dismutase 1	Homo sapiens	52-57
7599250-6	1995	On the basis of the survival time of rats exposed to more than 96% oxygen, it is suggested that a decrease in CuZn-SOD activity due to copper deficiency increases oxygen susceptibility.	Oxygen	67-73	superoxide dismutase 1	Rattus norvegicus	110-118
7599250-6	1995	On the basis of the survival time of rats exposed to more than 96% oxygen, it is suggested that a decrease in CuZn-SOD activity due to copper deficiency increases oxygen susceptibility.	Oxygen	163-169	superoxide dismutase 1	Rattus norvegicus	110-118
7865216-5	1995	Addition of the potent macrophage-activating agent interferon-gamma (IFN-gamma) to cultured PM further increased FcR-mediated phagocytosis in normoxic PM but had no effect on PM cultured in 100% O2.	Oxygen	195-197	interferon gamma	Mus musculus	51-67
7864128-1	1995	We tested the hypothesis that reducing the hepatic O2 supply by 30 min of constant-flow hypoxia (PO2, approximately 45 Torr) following gram-negative bacteremia downregulates tumor necrosis factor-alpha (TNF-alpha) in buffer-perfused rat lives (total n = 44).	Oxygen	51-53	tumor necrosis factor	Rattus norvegicus	174-201
7864128-1	1995	We tested the hypothesis that reducing the hepatic O2 supply by 30 min of constant-flow hypoxia (PO2, approximately 45 Torr) following gram-negative bacteremia downregulates tumor necrosis factor-alpha (TNF-alpha) in buffer-perfused rat lives (total n = 44).	Oxygen	51-53	tumor necrosis factor	Rattus norvegicus	203-212
7696062-8	1995	In the control group there were no changes in splanchnic blood flow and oxygen delivery, while splanchnic oxygen consumption increased (36 vs 39 ml min-1 m-2) (P &lt; 0.05) and gastric mucosal pH tended to decrease (7.33 vs 7.29) (ns).	Oxygen	106-112	CD59 molecule (CD59 blood group)	Homo sapiens	148-153
7551811-1	1995	NADPH-cytochrome P-450 reductase catalyzes one-electron reduction of aminochrome to the corresponding ortho-semiquinone, which was found to be unstable as indicated by the occurrence of NADPH oxidation and oxygen consumption.	Oxygen	206-212	cytochrome p450 oxidoreductase	Homo sapiens	0-32
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	60-66	catalase	Homo sapiens	48-56
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	60-66	cytochrome p450 oxidoreductase	Homo sapiens	270-302
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	60-66	NAD(P)H quinone dehydrogenase 1	Homo sapiens	307-320
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	197-203	catalase	Homo sapiens	48-56
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	197-203	cytochrome p450 oxidoreductase	Homo sapiens	270-302
7551811-4	1995	However, the effect of superoxide dismutase and catalase on oxygen consumption was found to differ from the effect on NADH or NADPH oxidation, since these enzymes, alone or together, inhibited the oxygen consumption during the reduction of aminochrome catalyzed by both NADPH-cytochrome P-450 reductase and DT-diaphorase.	Oxygen	197-203	NAD(P)H quinone dehydrogenase 1	Homo sapiens	307-320
7696519-5	1995	In addition, from the proximal histidine resonances, we have observed a preference for the binding of oxygen to the alpha-chain (up to about 10%) of hemoglobin over the beta-chain in both the presence and absence of 2,3-diphosphoglycerate.	Oxygen	102-108	Fc gamma receptor and transporter	Homo sapiens	116-127
12228374-5	1995	From experiments with KCN and salicylhydroxamic acid, it was estimated that the capacity of the cytochrome pathway was at least 100 nmol O2 mg-1 protein min-1 and the capacity of the alternative oxidase was at least 50 nmol O2 mg-1 protein min-1.	Oxygen	137-139	uncharacterized protein	Chlamydomonas reinhardtii	153-158
12228374-5	1995	From experiments with KCN and salicylhydroxamic acid, it was estimated that the capacity of the cytochrome pathway was at least 100 nmol O2 mg-1 protein min-1 and the capacity of the alternative oxidase was at least 50 nmol O2 mg-1 protein min-1.	Oxygen	137-139	uncharacterized protein	Chlamydomonas reinhardtii	240-245
7846037-2	1995	A subset of individuals with familial autosomal dominant forms of the disease have mutations of the copper/zinc superoxide dismutase (Cu/Zn SOD, SOD-1) gene, which encodes a ubiquitously expressed enzyme that plays a key role in oxygen free radical scavenging.	Oxygen	229-235	superoxide dismutase 1, soluble	Mus musculus	145-150
7827090-4	1995	In rhodopsin, the NMR data constrain one of the carboxylate oxygens (O1) of Glu113 to be approximately 3 A from the C12 position of the retinal with the second oxygen oriented away from the conjugated retinal chain.	Oxygen	60-67	rhodopsin	Homo sapiens	3-12
7827090-4	1995	In rhodopsin, the NMR data constrain one of the carboxylate oxygens (O1) of Glu113 to be approximately 3 A from the C12 position of the retinal with the second oxygen oriented away from the conjugated retinal chain.	Oxygen	60-66	rhodopsin	Homo sapiens	3-12
7805238-11	1995	The administration of 35% O2 at high altitude normalized arterial PO2, tended to decrease endothelin-1, and decreased pulmonary artery pressure accordingly.	Oxygen	26-28	endothelin 1	Homo sapiens	90-102
7851416-4	1995	Induction of HSP27 kinase activity by TNF or H2O2 was completely inhibited by first treating the cells with the antioxidant N-acetyl-L-cysteine, suggesting that generation of reactive oxygen metabolites was the key triggering element of this induction.	Oxygen	184-190	tumor necrosis factor	Homo sapiens	38-41
7779435-4	1995	SaF cells primed in vitro for 24 h at tumour relevant oxygen tensions required at least four times more TNF to reduce cell number to 50% of controls following a 24 h incubation period in 21% oxygen.	Oxygen	54-60	tumor necrosis factor	Homo sapiens	104-107
7779435-4	1995	SaF cells primed in vitro for 24 h at tumour relevant oxygen tensions required at least four times more TNF to reduce cell number to 50% of controls following a 24 h incubation period in 21% oxygen.	Oxygen	191-197	tumor necrosis factor	Homo sapiens	104-107
7779435-6	1995	The oxygen sensitizing effect is transient as the resistance of hypoxic cells to TNF was reversed after 24 h incubation in air.	Oxygen	4-10	tumor necrosis factor	Homo sapiens	81-84
8629477-7	1995	Maximal oxygen uptake increased progressively from 62.9 +/- 5.8 ml.kg-1.min-1 two weeks prior to taper, to a significantly higher level 68.9 +/- 4.2 ml.kg-1.min-1 during the final week of Taper 2 (p &lt; or = 0.5).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	157-162
7840232-0	1995	Altered expression of type I collagen, TGF-beta 1, and related genes in rat lung exposed to 85% O2.	Oxygen	96-98	transforming growth factor, beta 1	Rattus norvegicus	39-49
7840232-4	1995	TGF-beta 1 immunoreactivity was only detected on day 14 of 85% O2 exposure and was localized primarily to the pulmonary epithelium.	Oxygen	63-65	transforming growth factor, beta 1	Rattus norvegicus	0-10
7840232-6	1995	Increased mRNA expressions of interstitial collagenase and TIMP preceded those of type I collagen and TGF-beta 1, occurring at 4-6 days of exposure to 85% O2, while there was no significant change in stromelysin mRNA.	Oxygen	155-157	transforming growth factor, beta 1	Rattus norvegicus	102-112
7840232-7	1995	These findings are compatible with the initial O2-mediated increase in type I collagen deposition being a result of an altered proteinase/antiproteinase balance in the lung, and the subsequent more marked deposition being a response to increased TGF-beta 1 synthesis.	Oxygen	47-49	transforming growth factor, beta 1	Rattus norvegicus	246-256
7832763-5	1995	of 1500 nmol of O2/nmol of enzyme, whereas hCOX-2 had a specific activity of 12.2 mumol of O2/mg with a Km of 8.7 microM for arachidonate and a Vmax.	Oxygen	91-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
7529500-1	1995	The nitric oxide synthases (NOS) are a class of enzymes responsible for the generation of NO via an oxygen and NADPH dependent oxidation of the amino acid arginine.	Oxygen	100-106	nitric oxide synthase 2	Homo sapiens	4-26
7811748-1	1995	The lipophilic antioxidant 3,5-di-t-butyl-4-hydroxytoluene (BHT) and the structurally-related antiatherogenic drug probucol stimulate the oxygenation of mitochondrial membranes and erythrocyte ghosts by the rabbit 15-lipoxygenase as indicated by an increase in oxygen consumption as well as by an enhanced loss of polyenoic fatty acids and by the formation of specific lipoxygenase products in the membrane phospholipids.	Oxygen	138-144	arachidonate 15-lipoxygenase	Homo sapiens	214-229
8629477-7	1995	Maximal oxygen uptake increased progressively from 62.9 +/- 5.8 ml.kg-1.min-1 two weeks prior to taper, to a significantly higher level 68.9 +/- 4.2 ml.kg-1.min-1 during the final week of Taper 2 (p &lt; or = 0.5).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
7531947-5	1995	The external factor responsible for this induction may be hypoxia, given that we found that low oxygen tension caused a (reversible) increase in the VPF mRNA levels in otherwise low expressing melanoma lines in vitro.	Oxygen	96-102	vascular endothelial growth factor A	Homo sapiens	149-152
7748108-10	1995	These results suggest that part of the molecular oxygen evolved on addition of hydrogen peroxide to human saliva is in a singlet state and that molecular oxygen is evolved by oxidation of hydrogen peroxide, which may be catalysed by OSCN- bound to salivary peroxidase.	Oxygen	49-55	lactoperoxidase	Homo sapiens	248-267
7756034-10	1995	TNF alpha is a very potent inflammatory mediator, stimulating cells for release of several cytokines attracting polymorphonuclear neutrophil granulocytes (PMNs), which release proteolytic enzymes and toxic oxygen radicals.	Oxygen	206-212	tumor necrosis factor	Homo sapiens	0-9
7748108-10	1995	These results suggest that part of the molecular oxygen evolved on addition of hydrogen peroxide to human saliva is in a singlet state and that molecular oxygen is evolved by oxidation of hydrogen peroxide, which may be catalysed by OSCN- bound to salivary peroxidase.	Oxygen	154-160	lactoperoxidase	Homo sapiens	248-267
8527225-2	1995	The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply.	Oxygen	58-64	erythropoietin	Homo sapiens	12-15
8673470-3	1995	We examined the responsiveness of the FA complementation group C (FAC) gene to changes in oxygen concentration using two types of human cell lines, hypoxia-responsive Hep3B hepatoma cells and Epstein-Barr virus-immortalized lymphoblasts (normal and FA complementation groups B and C).	Oxygen	90-96	FA complementation group C	Homo sapiens	38-64
8527225-2	1995	The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply.	Oxygen	112-118	erythropoietin	Homo sapiens	12-15
8673470-3	1995	We examined the responsiveness of the FA complementation group C (FAC) gene to changes in oxygen concentration using two types of human cell lines, hypoxia-responsive Hep3B hepatoma cells and Epstein-Barr virus-immortalized lymphoblasts (normal and FA complementation groups B and C).	Oxygen	90-96	FA complementation group C	Homo sapiens	66-69
8565974-1	1995	The response of plasma insulin-like growth factor I (IGF I) to exercise-induced increase of total human growth hormone concentration [hGHtot] and of its molecular species [hGH20kD] was investigated up to 48 h after an 1-h ergometer exercise at 60% of maximal capacity during normoxia (N) and hypoxia (H) (inspiratory partial pressure of oxygen = 92 mmHg (12.7 kPa); n = 8).	Oxygen	337-343	insulin like growth factor 1	Homo sapiens	23-51
8521084-5	1995	However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved: how and at which subcellular level, do the cells produce these reactive oxygen intermediates that will contribute to NF kappa B activation in response to IL-1 or TNF-alpha?	Oxygen	207-213	nuclear factor kappa B subunit 1	Homo sapiens	252-262
8521084-5	1995	However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved: how and at which subcellular level, do the cells produce these reactive oxygen intermediates that will contribute to NF kappa B activation in response to IL-1 or TNF-alpha?	Oxygen	207-213	tumor necrosis factor	Homo sapiens	297-306
8521084-7	1995	In this paper, we will briefly overview this basic issue in cell biology and highlight some of the recent experimental data that will help us to understand the exact role of reactive oxygen intermediates in NF kappa B activation and the molecular mechanisms involved.	Oxygen	183-189	nuclear factor kappa B subunit 1	Homo sapiens	207-217
8521085-4	1995	Induction of NF kappa B and HIV replication are at least in part dependent on reactive oxygen intermediates.	Oxygen	87-93	nuclear factor kappa B subunit 1	Homo sapiens	13-23
7662350-1	1995	Cu, Zn superoxide dismutase (SOD) is a metalloprotein that catalyzes the dismutation of the superoxide anion into O2- and H2O2, and therefore functions to maintain a low intracellular concentration of an otherwise toxic metabolite of oxygen.	Oxygen	114-116	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	29-32
7662350-1	1995	Cu, Zn superoxide dismutase (SOD) is a metalloprotein that catalyzes the dismutation of the superoxide anion into O2- and H2O2, and therefore functions to maintain a low intracellular concentration of an otherwise toxic metabolite of oxygen.	Oxygen	234-240	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	29-32
8983921-6	1995	At rest the results revealed that only oxygen uptake was significantly lower (P &lt; 0.05) in the morning compared to that observed in the evening [2.9 (SD 0.4) compared to 3.5 (SD 0.5) ml O2.kg-1.min-1, respectively].	Oxygen	39-45	CD59 molecule (CD59 blood group)	Homo sapiens	197-202
9704092-2	1995	The normal kidney produces EPO to maintain erythrocyte for oxygen supply.	Oxygen	59-65	erythropoietin	Homo sapiens	27-30
7712690-3	1995	Peak pulmonary oxygen uptake (VO2) during maximal AE in normoxia and hypoxia was 2.25 +/- 0.15 and 2.18 +/- 0.14 l min-1, respectively (P &lt; 0.05).	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
7705391-4	1995	Neutrophils treated with nitroprusside and activated with FMLP, type I collagen or PMA decreased their extracellular release of oxygen metabolites, while their intracellular release was almost unaffected.	Oxygen	128-134	formyl peptide receptor 1	Homo sapiens	58-62
8565974-1	1995	The response of plasma insulin-like growth factor I (IGF I) to exercise-induced increase of total human growth hormone concentration [hGHtot] and of its molecular species [hGH20kD] was investigated up to 48 h after an 1-h ergometer exercise at 60% of maximal capacity during normoxia (N) and hypoxia (H) (inspiratory partial pressure of oxygen = 92 mmHg (12.7 kPa); n = 8).	Oxygen	337-343	insulin like growth factor 1	Homo sapiens	53-58
7590513-3	1995	Hypoxic incubation decreased the oxygen burst and maximum aggregation induced by thrombin, and accelerated anaerobic glycolysis.	Oxygen	33-39	coagulation factor II, thrombin	Homo sapiens	81-89
8682618-3	1995	S-nitroso-N-acetylpenicillamine (SNAP), which generates NO when placed in an aqueous solution, and 3-morpholinosydnonimine (SIN-1), which liberates NO and O2-, resulting in the formation of peroxynitrite, were used as NO donors.	Oxygen	155-157	MAPK associated protein 1	Homo sapiens	124-129
7607614-5	1995	To identify the signalling pathway involved, we used; (a) monoclonal antibody MA-5, directed against the alpha-subunit of the insulin receptor, that partially mimics insulin without activating tyrosine kinase; (b) H7, an inhibitor of PKC involved in O2- production in PMNLs, and (c) phorbol myristate acetate (PMA) that binds and stimulates PKC.	Oxygen	250-252	insulin	Homo sapiens	126-133
7549523-2	1995	This study examined the effect of adherence to fibronectin on radical oxygen products from eosinophils.	Oxygen	70-76	fibronectin 1	Homo sapiens	47-58
7829975-0	1995	LPS inhibits the intracellular growth of Legionella pneumophila in thioglycolate elicited murine peritoneal macrophages by iron-dependent, tryptophan-independent, oxygen-independent, and arginine-independent mechanisms.	Oxygen	163-169	toll-like receptor 4	Mus musculus	0-3
7798329-6	1995	From the TCA cycle rate the brain oxygen consumption was estimated to be 2.14 +/- 0.48 mumol min-1 g-1 (5.07 +/- 1.14 ml 100 g-1 min-1; n = 4), and the rate of brain glucose consumption was calculated to be 0.37 +/- 0.08 mumol min-1 g-1 (n = 4).	Oxygen	34-40	CD59 molecule (CD59 blood group)	Homo sapiens	93-98
7798329-6	1995	From the TCA cycle rate the brain oxygen consumption was estimated to be 2.14 +/- 0.48 mumol min-1 g-1 (5.07 +/- 1.14 ml 100 g-1 min-1; n = 4), and the rate of brain glucose consumption was calculated to be 0.37 +/- 0.08 mumol min-1 g-1 (n = 4).	Oxygen	34-40	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
7798329-6	1995	From the TCA cycle rate the brain oxygen consumption was estimated to be 2.14 +/- 0.48 mumol min-1 g-1 (5.07 +/- 1.14 ml 100 g-1 min-1; n = 4), and the rate of brain glucose consumption was calculated to be 0.37 +/- 0.08 mumol min-1 g-1 (n = 4).	Oxygen	34-40	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
7602073-14	1995	NF-kappa B-mediated transactivation by MHBst can be suppressed by radical scavenging antioxidants, indirectly suggesting that reactive oxygen intermediates are involved.	Oxygen	135-141	nuclear factor kappa B subunit 1	Homo sapiens	0-10
8867670-3	1995	Here we demonstrate that PGHS1 peroxidase, a NSAID-insensitive activity of PGHS1, mediates NF-kappa B activation through an intracellular reactive oxygen signaling pathway.	Oxygen	147-153	prostaglandin-endoperoxide synthase 1	Homo sapiens	25-30
7995955-9	1995	In L929 cells, the killing induced by TNF-alpha and oxidative stress is thought to occur through the accumulation of intracellular reactive oxygen intermediates.	Oxygen	140-146	tumor necrosis factor	Mus musculus	38-47
8913931-5	1995	TNF treatment of L929 leads to reactive oxygen formation in the mitochondria, resulting in cell death by necrosis.	Oxygen	40-46	tumor necrosis factor	Mus musculus	0-3
7995955-10	1995	Hence, our data suggest that the small hsps from different species share the property to protect L929 cells against the deleterious effects of reactive oxygen intermediates generated by either TNF-alpha or oxidative stress.	Oxygen	152-158	tumor necrosis factor	Mus musculus	193-202
8867670-3	1995	Here we demonstrate that PGHS1 peroxidase, a NSAID-insensitive activity of PGHS1, mediates NF-kappa B activation through an intracellular reactive oxygen signaling pathway.	Oxygen	147-153	prostaglandin-endoperoxide synthase 1	Homo sapiens	75-80
8867670-3	1995	Here we demonstrate that PGHS1 peroxidase, a NSAID-insensitive activity of PGHS1, mediates NF-kappa B activation through an intracellular reactive oxygen signaling pathway.	Oxygen	147-153	nuclear factor kappa B subunit 1	Homo sapiens	91-101
7731169-9	1995	Coincubation with superoxide dismutase and catalase, enzymes removing O2- and H2O2, completely eliminated oxidized LDL and Lp(a)-stimulated renin release.	Oxygen	70-72	catalase	Mus musculus	43-51
7658316-1	1995	In has been long recognized that erythropoiesis in adults is under control of erythropoietin, a glycoprotein produced mainly by adult kidneys in inverse relation to oxygen availability.	Oxygen	165-171	erythropoietin	Homo sapiens	78-92
7658316-3	1995	The primary site of EPO production during fetal and neonatal life is the liver, and the fetus has been shown to be able to increase EPO production in response to hypoxia through intrinsic oxygen sensing mechanisms of hepatocytes.	Oxygen	188-194	erythropoietin	Homo sapiens	132-135
7658323-0	1995	The oxygen sensor that controls EPO production: facts and fancies.	Oxygen	4-10	erythropoietin	Homo sapiens	32-35
7658323-4	1995	One of the cardinal issues of crucial importance, in this context, is relating to the nature of the "oxygen deficit sensor" which, for example, leads to increased expression of hematopoietic hormones (erythropoietin) or angiogenesis factors (Vascular Endothelial Growth Factors, VEGF).	Oxygen	101-107	erythropoietin	Homo sapiens	201-215
7658323-4	1995	One of the cardinal issues of crucial importance, in this context, is relating to the nature of the "oxygen deficit sensor" which, for example, leads to increased expression of hematopoietic hormones (erythropoietin) or angiogenesis factors (Vascular Endothelial Growth Factors, VEGF).	Oxygen	101-107	vascular endothelial growth factor A	Homo sapiens	279-283
7658323-5	1995	Molecular principles of such oxygen sensors are accurately defined only for certain systems: In the case of erythropoietin, only one fully known section in the 3"-region of the erythropoietin gene is necessary and is sufficient to "transfer" O2-sensitivity to that particular gene.	Oxygen	29-35	erythropoietin	Homo sapiens	108-122
7658323-5	1995	Molecular principles of such oxygen sensors are accurately defined only for certain systems: In the case of erythropoietin, only one fully known section in the 3"-region of the erythropoietin gene is necessary and is sufficient to "transfer" O2-sensitivity to that particular gene.	Oxygen	29-35	erythropoietin	Homo sapiens	177-191
7658325-1	1995	All forms of oxygen deprivation act as a stimulus for the production of the hormone erythropoietin.	Oxygen	13-19	erythropoietin	Homo sapiens	84-98
7658325-3	1995	The hormone"s name is a succint description of its main effect: erythropoietin stimulates red cell production from bone marrow precursors and hence controls the O2-carrying capacity of the blood.	Oxygen	161-163	erythropoietin	Homo sapiens	64-78
7811268-2	1994	CA enhanced O2-generation in FMLP-stimulated DMSO-HL60.	Oxygen	12-14	formyl peptide receptor 1	Homo sapiens	29-33
7770288-9	1995	Supplemental oxygen was discontinued at a younger postconceptional age in babies with a positive cortisol response to ACTH (P &lt; .01) and fewer of those babies were on supplemental oxygen at 36-week postconceptional age (P &lt; .01).	Oxygen	13-19	proopiomelanocortin	Homo sapiens	118-122
7770288-10	1995	CONCLUSIONS: At the end of the first week of life, infants who subsequently developed BPD and prolonged oxygen dependence had significantly lower cortisol secretion in response to ACTH than infants who recovered without BPD.	Oxygen	104-110	proopiomelanocortin	Homo sapiens	180-184
7543339-3	1995	The expression of VEGF mRNA was greatly enhanced by hypoxic cultivation (2% oxygen) when compared with normoxic cultivation (20% oxygen), while the expression of bFGF mRNA by RGCs was not significantly affected by hypoxia.	Oxygen	76-82	vascular endothelial growth factor A	Homo sapiens	18-22
7543339-3	1995	The expression of VEGF mRNA was greatly enhanced by hypoxic cultivation (2% oxygen) when compared with normoxic cultivation (20% oxygen), while the expression of bFGF mRNA by RGCs was not significantly affected by hypoxia.	Oxygen	129-135	vascular endothelial growth factor A	Homo sapiens	18-22
7603300-4	1995	The higher affinity vanilloid receptor, VN1 can be distinguished on the basis of initiating vasoconstriction at low doses of capsaicin and simultaneously stimulating oxygen consumption.	Oxygen	166-172	vomeronasal 1 receptor 105	Rattus norvegicus	40-43
7776904-8	1995	We propose that the release of MyPo from neutrophils and subsequent binding to macrophages initiates a cascade of events which enhance the production of reactive oxygen intermediates and cytokine expression resulting in the chronic inflammatory state associated with autoimmune diseases.	Oxygen	162-168	myeloperoxidase	Homo sapiens	31-35
7568419-2	1995	hTNF-alpha also enhanced the response of polymorphonuclear neutrophils (PMN) by its priming action and resulted in the increased generation of active oxygen which in turn may be responsible for the tissue injury.	Oxygen	150-156	tumor necrosis factor	Homo sapiens	0-10
7809835-2	1995	The free radical scavengers superoxide dismutase and catalase and a xanthine oxidase inhibitor, allopurinol, ameliorate this injury response, suggesting that toxic oxygen metabolites generated by xanthine oxidase play an intermediary role.	Oxygen	164-170	catalase	Canis lupus familiaris	53-61
7571892-4	1995	For a normal systemic oxygen consumption of 120 ml min-1 m-2 a critical degree of hemodilution is achieved at an hematocrit of 14% and an hemoglobin content of 4.7 g dl-1, respectively.	Oxygen	22-28	CD59 molecule (CD59 blood group)	Homo sapiens	51-56
7571892-6	1995	An increase of systemic oxygen consumption by a factor of three (460 ml min-1 m-2), which might be typical for a patient during the postoperative recovery phase, increases the critical hematocrit to 21%.	Oxygen	24-30	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
7811268-4	1994	FMLP by itself induced O2-generation, however, it did not induce 8OHdG.	Oxygen	23-25	formyl peptide receptor 1	Homo sapiens	0-4
7810671-11	1994	Our data demonstrate that SP-A only enhances oxygen radical release from AM if SP-A is fixed to zymosan or the surface of the reaction vial in vitro.	Oxygen	45-51	surfactant protein A1	Rattus norvegicus	26-30
7882037-6	1994	Increases in [Ca2+]i induced by oxygen-glucose deprivation were inhibited in the vicinity of the injury 1 and 3 days after injury.	Oxygen	32-38	carbonic anhydrase 2	Mus musculus	14-17
7810637-1	1994	Whole body lipid kinetics were evaluated during basal resting conditions, 4 h of treadmill exercise eliciting an oxygen uptake of 20 ml.kg-1.min-1, and 1 h of recovery in five untrained and five endurance-trained men.	Oxygen	113-119	CD59 molecule (CD59 blood group)	Homo sapiens	141-146
7809170-1	1994	We have measured the oxygen concentration in the body water of murine FSa and NFSa fibrosarcomas using a new method for quantitative oxygen concentration determination deep in the tissues of a living animal.	Oxygen	21-27	RIKEN cDNA 4932438A13 gene	Mus musculus	70-73
7527657-1	1994	The nitric oxide synthases (NOS) are a unique family of P450-type hemoproteins that catalyze the formation of .NO and citrulline from L-arginine, oxygen, and NADPH.	Oxygen	146-152	nitric oxide synthase 2	Homo sapiens	4-26
7810671-11	1994	Our data demonstrate that SP-A only enhances oxygen radical release from AM if SP-A is fixed to zymosan or the surface of the reaction vial in vitro.	Oxygen	45-51	surfactant protein A1	Rattus norvegicus	79-83
7892983-5	1994	Oxygen was administered through nasal cannulae at a flow of 2 l.min-1.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
7705312-9	1994	R-rolipram-elevated eosinophil cyclic AMP content (EC50 = 1.7 microM) and inhibited fMLP-induced O2- production in a concentration-dependent manner (IC50 = 0.3 microM).	Oxygen	97-99	formyl peptide receptor 1	Homo sapiens	84-88
7847895-5	1994	For soluble catalase, it is found that in the range of pressures studied, the oxygen flow rate increases with increase in pressure up to a certain value and then decreases.	Oxygen	78-84	catalase	Homo sapiens	12-20
7535686-4	1994	Neutrophil numbers in bronchoalveolar lavage fluid peaked after 60 hr of exposure to s 95% oxygen; this was associated with a marked upregulation of mRNA for the adhesion molecules P-selectin and E-selectin but not VCAM-1.	Oxygen	91-97	selectin P	Rattus norvegicus	181-191
7708812-7	1994	These results indicate that etodolac is an anti-inflammatory drug which suppress IL-1 beta-stimulated PGE2 biosynthesis in rabbit articular chondrocytes, active oxygen generation and bradykinin formation.	Oxygen	161-167	interleukin-1 beta	Oryctolagus cuniculus	81-90
7964502-5	1994	The mechanism stimulating synthesis and release of IL-6 antigen by astrocytes was probably production of reactive oxygen intermediates (ROIs), which occurred within 15-20 minutes after placing hypoxia cultures back into normoxia, as the inhibitor diphenyl iodonium inhibited the burst of ROIs and subsequent IL-6 generation (blockade of nitric oxide formation had no effect on ROI generation or IL-6 production).	Oxygen	114-120	interleukin 6	Rattus norvegicus	51-55
7863047-3	1994	OBJECTIVES: 1) to determine serum ACE activity in patients with COPD treated with and without continuous ambulatory oxygen therapy (CAOT); 2) to verify whether there is a correlation between ACE and any hematological, spirometric or gasometric parameter.	Oxygen	116-122	angiotensin I converting enzyme	Homo sapiens	34-37
7708139-6	1994	Neutrophil aggregation was increased within 30 min of TGF-beta 1 infusion when compared to control (2.07 +/- 0.70 vs 1.09 +/- 0.17 ohms, p &lt; 0.05); neutrophil chemiluminescence, an index of the oxygen respiratory burst was not significantly affected by TGF-beta 1 administration.	Oxygen	197-203	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	54-64
7955684-8	1994	Therefore, the activity of the oxygen scavengers, superoxide dismutase and catalase, was measured in the cyst fluid of 9 cases of simple bone cyst as an indicator of high oxygen-free radical content in the cyst.	Oxygen	31-37	catalase	Homo sapiens	75-83
7954411-3	1994	O2- generation, determined as O2- release from the PMA-stimulated cells by the reduction of cytochrome c, was dependent on the dose of PMA and reached almost maximal with 2.0 nM PMA.	Oxygen	0-2	cytochrome c, somatic	Homo sapiens	92-104
7800476-8	1994	Consistent with a requirement for HAP1 in protection against hypoxic stress, expression of the HAP1 protein was found to be induced in a time-dependent manner in human cells during growth under 1% oxygen.	Oxygen	197-203	huntingtin associated protein 1	Homo sapiens	95-99
7800476-10	1994	We conclude that the HAP1 protein is a key factor in cellular protection against a wide variety of cellular stresses, including DNA damage and a change in oxygen tension.	Oxygen	155-161	huntingtin associated protein 1	Homo sapiens	21-25
7872005-9	1994	Oxygen uptake, measured during the exercise and recovery periods of sprints 6-9, was lower in the hypoxic condition [3.03 (0.2) vs. 3.19 (0.2) 1 min-1, P &lt; 0.05].	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	145-150
7946380-0	1994	Temporal and spatial expression of biglycan in chronic oxygen-induced lung injury.	Oxygen	55-61	biglycan	Rattus norvegicus	35-43
7946380-6	1994	Immunoreactive biglycan decreased with postnatal age but increased in alveolar cells of animals exposed to 100% oxygen for 4 wk and in alveolar cells and along alveolar septae of animals exposed to 85% oxygen for 6 wk.	Oxygen	112-118	biglycan	Rattus norvegicus	15-23
7946380-6	1994	Immunoreactive biglycan decreased with postnatal age but increased in alveolar cells of animals exposed to 100% oxygen for 4 wk and in alveolar cells and along alveolar septae of animals exposed to 85% oxygen for 6 wk.	Oxygen	202-208	biglycan	Rattus norvegicus	15-23
8082230-3	1994	DT-diaphorase catalyzes the reduction of cDoQ to the corresponding hydroquinone (cDoQH2), which was found to be unstable in the presence of oxygen.	Oxygen	140-146	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
8082230-8	1994	In the presence of DETAPAC, the addition of SOD inhibited NADH oxidation during cDoQH2 autoxidation 75%, suggesting that superoxide radicals are responsible for 75% of the oxygen-dependent autoxidation.	Oxygen	172-178	superoxide dismutase 1	Homo sapiens	44-47
8082230-11	1994	A nearly complete inhibition (90%) of oxygen consumption during the reduction of cDoQ by DT-diaphorase was observed when SOD alone or SOD and catalase were added to the incubation mixture containing DETAPAC.	Oxygen	38-44	NAD(P)H quinone dehydrogenase 1	Homo sapiens	89-102
8082230-11	1994	A nearly complete inhibition (90%) of oxygen consumption during the reduction of cDoQ by DT-diaphorase was observed when SOD alone or SOD and catalase were added to the incubation mixture containing DETAPAC.	Oxygen	38-44	superoxide dismutase 1	Homo sapiens	121-124
8082230-11	1994	A nearly complete inhibition (90%) of oxygen consumption during the reduction of cDoQ by DT-diaphorase was observed when SOD alone or SOD and catalase were added to the incubation mixture containing DETAPAC.	Oxygen	38-44	superoxide dismutase 1	Homo sapiens	134-150
7532811-7	1994	As a cytochrome P-450, NOS catalyzes a heme-mediated reduction of molecular oxygen, resulting in the formation of H2O2 in the absence of L-arginine.	Oxygen	76-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	5-21
7851351-8	1994	Oxygen uptake decreased in both groups after induction (sufentanil 289 +/- 29 to 184 +/- 21 ml min-1; fentanyl 318 +/- 32 to 216 +/- 32 ml min-1) and remained low with sufentanil until flumazenil was given.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
7851351-8	1994	Oxygen uptake decreased in both groups after induction (sufentanil 289 +/- 29 to 184 +/- 21 ml min-1; fentanyl 318 +/- 32 to 216 +/- 32 ml min-1) and remained low with sufentanil until flumazenil was given.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	139-144
7868455-1	1994	In a previous study we found a significant temporary decrease in the ratio of CD4/CD8 (helper, inducer/suppressor, cytotoxic) T lymphocytes in the peripheral blood of healthy human volunteers after exposure to a single commonly used profile of hyperbaric oxygen (HBO).	Oxygen	255-261	CD4 molecule	Homo sapiens	78-81
7968598-6	1994	In diabetic patients (n = 30), plasma O2- levels correlated with basal MLF (r = -.59, P &lt; .005), basal MPM (r = -.84, P &lt; .001), fasting plasma insulin level (r = .51, P &lt; .004), WBGD (r = -.53, P &lt; .002), and nonoxidative (r = -.45, P &lt; .01) glucose metabolism.	Oxygen	38-40	insulin	Homo sapiens	150-157
7968598-7	1994	In conclusion, our results demonstrate that a relationship between plasma O2- levels and insulin action occurs in non-insulin-dependent diabetics.	Oxygen	74-76	insulin	Homo sapiens	89-96
7935419-1	1994	Oxygen toxicity in Saccharomyces cerevisiae strains lacking superoxide dismutase can be suppressed through mutations in either the BSD1 or BSD2 gene.	Oxygen	0-6	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	131-135
7918470-2	1994	In the native calcium-binding protein calbindin D9k (M(r) 8.700; 75aa; 2 EF-hands), the backbone carbonyl oxygen of Glu60 coordinates the Ca2+ ion in the C-terminal site (site II).	Oxygen	106-112	S100 calcium binding protein G	Homo sapiens	38-51
7923153-4	1994	Furthermore, although conditions of low oxygen can also activate mitogen-activated protein kinases (ERK1 and ERK2), these kinases do not appear to be involved in regulating NF-kappa B by low oxygen conditions, as dominant negative mutants of mitogen-activated protein kinase do not inhibit NF-kappa B activation by hypoxia.	Oxygen	40-46	mitogen-activated protein kinase 3	Homo sapiens	100-104
7923153-4	1994	Furthermore, although conditions of low oxygen can also activate mitogen-activated protein kinases (ERK1 and ERK2), these kinases do not appear to be involved in regulating NF-kappa B by low oxygen conditions, as dominant negative mutants of mitogen-activated protein kinase do not inhibit NF-kappa B activation by hypoxia.	Oxygen	40-46	mitogen-activated protein kinase 1	Homo sapiens	109-113
7923153-5	1994	Since Ras and Raf-1 have been previously shown to work downstream from membrane-associated tyrosine kinases such as Src, we determined if the Src membrane-associated kinase was also activated by low oxygen conditions.	Oxygen	199-205	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	142-145
7923111-5	1994	This reduction in tumor size was prevented by the treatment of rabbits with superoxide dismutase and catalase, indicating that the generation of active oxygen species in the tumor was involved in the mechanism of action of DSMs.	Oxygen	152-158	catalase	Oryctolagus cuniculus	101-109
7944384-0	1994	Requirement of a second oxidation equivalent for ferryl oxygen transfer to styrene in the epoxidation catalyzed by myoglobin-H2O2.	Oxygen	56-62	myoglobin	Equus caballus	115-124
7944394-2	1994	The specific activity of Cox-2 in the microsomes of infected cells was 0.51 mumol O2/min/mg and was comparable to that obtained for partially purified Cox-2 from ovine placenta (0.55 mumol O2/min/mg).	Oxygen	82-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
7944394-2	1994	The specific activity of Cox-2 in the microsomes of infected cells was 0.51 mumol O2/min/mg and was comparable to that obtained for partially purified Cox-2 from ovine placenta (0.55 mumol O2/min/mg).	Oxygen	189-191	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
7980410-6	1994	Our results support the hypothesis that an H2O2-generating haem protein might be part of the O2 sensor that controls Epo production.	Oxygen	45-47	erythropoietin	Homo sapiens	117-120
7925300-10	1994	Furthermore, we found that the induction by hydrogen peroxide of NF-kappa B translocation to the nucleus, which is assumed to be triggered by reactive oxygen intermediates, also coincided with incorporation of phosphate into the same subunits that were modified after stimulation by TNF-alpha.	Oxygen	151-157	nuclear factor kappa B subunit 1	Homo sapiens	65-75
7522486-5	1994	At high O2 (680 mm Hg), basal NO was detectable and NO increased 6- to 10-fold with bradykinin or A23187.	Oxygen	8-10	kininogen 1	Homo sapiens	84-94
7833830-2	1994	It reduced the rate of methemoglobin formation from oxyhemoglobin exposed to nitric oxide generated from the reaction of hydroxylamine with Complex I of catalase and it decreased the amount of nitrite formed in the reaction of oxygen with nitric oxide generated from sodium nitroprusside.	Oxygen	227-233	catalase	Rattus norvegicus	153-161
7833842-0	1994	Oxygen regulation of TGF-beta 1 mRNA in human hepatoma (Hep G2) cells.	Oxygen	0-6	transforming growth factor beta 1	Homo sapiens	21-31
7833842-2	1994	We investigated the effect of oxygen on steady state levels of transforming growth factor-beta 1 mRNA in cultured human hepatoma cells.	Oxygen	30-36	transforming growth factor beta 1	Homo sapiens	63-96
7833842-3	1994	Northern blot analysis demonstrated that hypoxia mediated an early and sustained induction of TGF-beta 1 mRNA above that seen at higher oxygen tensions.	Oxygen	136-142	transforming growth factor beta 1	Homo sapiens	94-104
7833842-4	1994	The data suggests that modulation of TGF-beta 1 expression by the local oxygen environment may be important in tumour development and progression.	Oxygen	72-78	transforming growth factor beta 1	Homo sapiens	37-47
7852211-2	1994	EPO plays a key role in O2 homeostasis by regulating blood O2-carrying capacity.	Oxygen	24-26	erythropoietin	Homo sapiens	0-3
8001835-7	1994	Both DPI and DIMPDA, as well as BPI, blocked O2.- release by stimulated neutrophils.	Oxygen	45-47	bactericidal permeability-increasing protein	Cavia porcellus	32-35
7852211-2	1994	EPO plays a key role in O2 homeostasis by regulating blood O2-carrying capacity.	Oxygen	59-61	erythropoietin	Homo sapiens	0-3
7852211-8	1994	A kidney-derived cell line in which EPO expression is regulated by O2 tension has not been established.	Oxygen	67-69	erythropoietin	Homo sapiens	36-39
7852211-17	1994	Thus, the molecular mechanisms by which EPO transcription is regulated may also be utilized to control the expression of other genes responsible for cellular and systemic O2 homeostasis.	Oxygen	171-173	erythropoietin	Homo sapiens	40-43
7927667-2	1994	In contrast to the parental strain, the resulting htrA deletion mutant, designated PHE1, failed to grow on solid medium at 40 degrees C and demonstrated increased sensitivity to killing by H2O2 and O2- in disk sensitivity assays.	Oxygen	191-193	HtrA serine peptidase 1	Mus musculus	50-54
7843797-9	1994	Fibrinogen also inhibited, in a dose-dependent manner, the oxygen consumption of neutrophils activated by opsonized zymosan.	Oxygen	59-65	fibrinogen beta chain	Homo sapiens	0-10
7944692-4	1994	If exercise testing revealed a peak oxygen uptake of 15 mL.kg-1.min-1 or greater, the patient was offered surgical treatment.	Oxygen	36-42	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
27414180-4	1994	Oxygen in the ground state was found to be predominantly involved in the autoxidation of o-semiquinone during the reduction of noradrenochrome catalyzed by NADPH-cytocbrome P-450 reductase, since the addition of superoxide dismutase (SOD) to the incubation mixture only inhibited NADPH oxidation 13% and 6% in the absence and presence of DETAPAC, respectively.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	212-232
27414180-4	1994	Oxygen in the ground state was found to be predominantly involved in the autoxidation of o-semiquinone during the reduction of noradrenochrome catalyzed by NADPH-cytocbrome P-450 reductase, since the addition of superoxide dismutase (SOD) to the incubation mixture only inhibited NADPH oxidation 13% and 6% in the absence and presence of DETAPAC, respectively.	Oxygen	0-6	superoxide dismutase 1	Homo sapiens	234-237
7720127-2	1994	Plasma ET-1 like immunoreactivity (-LI) levels increased significantly at the fifth, fifteenth, sixtieth minute after hypoxia (fractional inspiratory O2 concentration 10%), but they had no remarkable change at the thirtieth minute.	Oxygen	150-152	endothelin 1	Canis lupus familiaris	7-11
8089148-6	1994	These results support the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-39
7925420-3	1994	The omega-hydroxylation requires both molecular oxygen and NADPH, and is inhibited by carbon monoxide, indicating involvement of a cytochrome P-450 (P-450).	Oxygen	48-54	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
7526150-1	1994	Previous studies have shown that exposure of phenobarbital-pretreated rats to halothane in 10% O2 causes centrilobular necrosis, induces expression of the 72-kDa heat shock protein (HSP72), and produces several trifluoroacetylated adducts.	Oxygen	95-97	selenoprotein K	Rattus norvegicus	162-180
7847833-6	1994	ETYA, a less selective inhibitor of 5-lipoxygenase that also inhibits cell replication, acutely reduced O2 uptake by 40%, but A63162 did not.	Oxygen	104-106	arachidonate 5-lipoxygenase	Homo sapiens	36-50
7944692-8	1994	Five patients whose peak oxygen uptake was lower than 15 mL.kg-1.min-1 also underwent surgical intervention; there was one death.	Oxygen	25-31	CD59 molecule (CD59 blood group)	Homo sapiens	65-70
7954653-6	1994	Locally administered bradykinin increased coronary artery conductance [2.62(0.39) v 4.71(1.07) ml.min-1.100 g-1.mm Hg-1], total myocardial blood flow, to 263(72) ml.min-1.100 g-1, and oxygen consumption, to 14.9(4.4) ml.min-1.100 g-1; however, heart rate-blood pressure product did not change.	Oxygen	184-190	kininogen 1	Canis lupus familiaris	21-31
7820974-8	1994	The integrated glucose-induced forearm oxygen uptake in the period 60-120 min following the glucose load was significantly reduced after beta-adrenergic inhibition from 103 +/- 28 mumol 100 g-1 60 min-1 to 29 +/- 29 mumol 100 g-1 60 min-1 (P &lt; 0.05).	Oxygen	39-45	CD59 molecule (CD59 blood group)	Homo sapiens	197-202
7821746-2	1994	It could also be shown that C-peptide administration increases blood flow, oxygen uptake and capillary diffusion capacity of exercising forearm muscle in IDDM patients, probably by increasing capillary recruitment in the working muscle.	Oxygen	75-81	insulin	Homo sapiens	28-37
7820974-8	1994	The integrated glucose-induced forearm oxygen uptake in the period 60-120 min following the glucose load was significantly reduced after beta-adrenergic inhibition from 103 +/- 28 mumol 100 g-1 60 min-1 to 29 +/- 29 mumol 100 g-1 60 min-1 (P &lt; 0.05).	Oxygen	39-45	CD59 molecule (CD59 blood group)	Homo sapiens	233-238
8065358-4	1994	Here we show that hypoxia and heat, agents that induce cellular stress primarily by inhibiting oxygen-dependent metabolism and denaturing proteins, respectively, also cause an increase in p53 protein levels.	Oxygen	95-101	tumor protein p53	Homo sapiens	188-191
7933988-16	1994	The VEGF gene appears to respond to hypoxia like the erythropoietin gene, and the mechanism of oxygen sensing probably is mediated by a heme-containing protein.	Oxygen	95-101	vascular endothelial growth factor A	Homo sapiens	4-8
7933988-16	1994	The VEGF gene appears to respond to hypoxia like the erythropoietin gene, and the mechanism of oxygen sensing probably is mediated by a heme-containing protein.	Oxygen	95-101	erythropoietin	Homo sapiens	53-67
8064127-1	1994	Pulmonary superoxide dismutase (SOD) plays an important role in the lung defense against O2 toxicity.	Oxygen	89-91	superoxide dismutase 1	Rattus norvegicus	32-35
8064127-2	1994	We have previously demonstrated that tracheal insufflation of interleukin-1 alpha (IL-1) selectively enhances pulmonary MnSOD and protects rats against O2 toxicity.	Oxygen	152-154	interleukin 1 alpha	Rattus norvegicus	62-81
8046241-4	1994	Moreover, the combination of adenosine and homocysteine changed the dependency of the TNF-alpha-mediated cytolysis on reactive oxygen intermediates.	Oxygen	127-133	tumor necrosis factor	Mus musculus	86-95
8070557-7	1994	This rationale also allows us to discuss the oxidation state of the prevailing oxygen reacting species with reference to the concentration of the two substrates (oxygen and cytochrome c) and to the structural state of the oxidase.	Oxygen	79-85	cytochrome c, somatic	Homo sapiens	173-185
8060347-2	1994	The amount of immunoreactive ET-1 secreted by the cardiac myocytes into the culture medium was much higher at the low oxygen condition.	Oxygen	118-124	endothelin 1	Rattus norvegicus	29-33
8060347-3	1994	An analysis of ET-1 binding capacity to the cardiac myocytes revealed that the receptor number of ET-1 was about two-fold at low oxygen culture condition.	Oxygen	129-135	endothelin 1	Rattus norvegicus	15-19
8060347-3	1994	An analysis of ET-1 binding capacity to the cardiac myocytes revealed that the receptor number of ET-1 was about two-fold at low oxygen culture condition.	Oxygen	129-135	endothelin 1	Rattus norvegicus	98-102
8060347-4	1994	In fact, an addition of ET-1 (1nM) increased in protein synthesis at the low but not the high oxygen culture condition.	Oxygen	94-100	endothelin 1	Rattus norvegicus	24-28
8060347-5	1994	Thus, the increase in ET-1 production and responsiveness to ET-1 in the cardiac myocytes at the low oxygen culture condition suggests that autocrine ET-1 might be involved in the maintenance of beating ability in heart at hypoxia.	Oxygen	100-106	endothelin 1	Rattus norvegicus	22-26
8060347-5	1994	Thus, the increase in ET-1 production and responsiveness to ET-1 in the cardiac myocytes at the low oxygen culture condition suggests that autocrine ET-1 might be involved in the maintenance of beating ability in heart at hypoxia.	Oxygen	100-106	endothelin 1	Rattus norvegicus	60-64
8060347-5	1994	Thus, the increase in ET-1 production and responsiveness to ET-1 in the cardiac myocytes at the low oxygen culture condition suggests that autocrine ET-1 might be involved in the maintenance of beating ability in heart at hypoxia.	Oxygen	100-106	endothelin 1	Rattus norvegicus	60-64
7975367-6	1994	Half the haemoglobin saturation (p50): characterizing the haemoglobin affinity for oxygen and corresponding to the shape and position of the haemoglobin saturation curve.	Oxygen	83-89	nuclear factor kappa B subunit 1	Homo sapiens	33-36
8060347-0	1994	Low oxygen enhances endothelin-1 (ET-1) production and responsiveness to ET-1 in cultured cardiac myocytes.	Oxygen	4-10	endothelin 1	Rattus norvegicus	20-32
8060347-0	1994	Low oxygen enhances endothelin-1 (ET-1) production and responsiveness to ET-1 in cultured cardiac myocytes.	Oxygen	4-10	endothelin 1	Rattus norvegicus	34-38
8060347-0	1994	Low oxygen enhances endothelin-1 (ET-1) production and responsiveness to ET-1 in cultured cardiac myocytes.	Oxygen	4-10	endothelin 1	Rattus norvegicus	73-77
7519607-1	1994	Neuronal nitric oxide synthase (NOS) is a calmodulin-dependent, flavin-containing hemoprotein that forms NO from L-arginine, NADPH, and molecular oxygen.	Oxygen	146-152	nitric oxide synthase 2	Homo sapiens	9-30
7519607-1	1994	Neuronal nitric oxide synthase (NOS) is a calmodulin-dependent, flavin-containing hemoprotein that forms NO from L-arginine, NADPH, and molecular oxygen.	Oxygen	146-152	calmodulin 1	Homo sapiens	42-52
7943703-5	1994	The oxygen flow was 2 l.min-1 and the average halothane consumption was 8 ml.h-1.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	24-29
8074242-10	1994	We conclude that IL-8 may be important in the pathogenesis of pulmonary oxygen toxicity and that therapeutic concentrations of dexamethasone can suppress production of this cytokine.	Oxygen	72-78	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
8050170-2	1994	In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different methods: superoxide dismutase (SOD) inhibitable cytochrome c reduction by O2- and nitroblue tetrazolium (NBT) reduction.	Oxygen	220-222	superoxide dismutase 1	Homo sapiens	155-175
7924169-4	1994	In patients, O2 consumption fell exponentially from 16.8 (13.7-20.0) ml min-1 kg-1 at peak exercise to 6.0 (5.2-6.7) ml min-1 kg-1 at 3 min of recovery and in control subjects it fell from 30.2 (27.0-33.5) ml min-1 kg-1 to 6.7 (5.9-7.4) ml min-1 kg-1 (mean and 95% confidence intervals).	Oxygen	13-15	CD59 molecule (CD59 blood group)	Homo sapiens	72-82
7924169-4	1994	In patients, O2 consumption fell exponentially from 16.8 (13.7-20.0) ml min-1 kg-1 at peak exercise to 6.0 (5.2-6.7) ml min-1 kg-1 at 3 min of recovery and in control subjects it fell from 30.2 (27.0-33.5) ml min-1 kg-1 to 6.7 (5.9-7.4) ml min-1 kg-1 (mean and 95% confidence intervals).	Oxygen	13-15	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
7924169-4	1994	In patients, O2 consumption fell exponentially from 16.8 (13.7-20.0) ml min-1 kg-1 at peak exercise to 6.0 (5.2-6.7) ml min-1 kg-1 at 3 min of recovery and in control subjects it fell from 30.2 (27.0-33.5) ml min-1 kg-1 to 6.7 (5.9-7.4) ml min-1 kg-1 (mean and 95% confidence intervals).	Oxygen	13-15	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
7924169-4	1994	In patients, O2 consumption fell exponentially from 16.8 (13.7-20.0) ml min-1 kg-1 at peak exercise to 6.0 (5.2-6.7) ml min-1 kg-1 at 3 min of recovery and in control subjects it fell from 30.2 (27.0-33.5) ml min-1 kg-1 to 6.7 (5.9-7.4) ml min-1 kg-1 (mean and 95% confidence intervals).	Oxygen	13-15	CD59 molecule (CD59 blood group)	Homo sapiens	120-130
7923521-4	1994	Supplemental oxygen was administered at 3 L.min-1 by nasal prongs.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
8044933-2	1994	To evaluate this hypothesis, we investigated whether low oxygen tension or cytokines known to promote neovascularization in vivo could modulate the expression of either vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) in human vascular smooth muscle cells (SMCs).	Oxygen	57-63	vascular endothelial growth factor A	Homo sapiens	169-203
8050170-2	1994	In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different methods: superoxide dismutase (SOD) inhibitable cytochrome c reduction by O2- and nitroblue tetrazolium (NBT) reduction.	Oxygen	220-222	superoxide dismutase 1	Homo sapiens	177-180
8050170-2	1994	In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different methods: superoxide dismutase (SOD) inhibitable cytochrome c reduction by O2- and nitroblue tetrazolium (NBT) reduction.	Oxygen	220-222	cytochrome c, somatic	Homo sapiens	194-206
8055951-8	1994	This complex may generate an active oxygen species, which induces the degradation of the imidazole ring at His10, leading to aggregation or fragmentation of insulin.	Oxygen	36-42	insulin	Homo sapiens	157-164
8050571-3	1994	The Epo production in HepG2 cells was also dependent on O2 tension for cell culture but the enhancement of Epo production by RA was independent of O2 tension, indicating that RA exerts its effect through a pathway different from O2.	Oxygen	56-58	erythropoietin	Homo sapiens	4-7
7519855-6	1994	This study suggests that H2O2 is not directly involved in NO synthesis and that the H2O2/catalase stimulation of NO synthase activity may be due to the excess oxygen produced by the H2O2/catalase system.	Oxygen	159-165	catalase	Rattus norvegicus	89-97
7822068-6	1994	The oxygen uptake at 15 km.h-1 (VO2 15) was lower (129 vs 138 ml.kg-0.75.min-1, p &lt; 0.01) and the VO2/velocity slope higher in the long-distance runners, with similar VO2 18 in the two groups.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	73-78
7914182-9	1994	These results indicate that enTNF exerts its intracellular protective effect against adriamycin-induced cytotoxicity by the same mechanism as that against exogenous TNF and heat, namely scavenging reactive oxygen with induced MnSOD.	Oxygen	206-212	tumor necrosis factor	Homo sapiens	30-33
7933490-1	1994	To prevent hypoxemia during one-lung anesthesia, we have devised an oxygen insufflation machine which can insufflate oxygen (0.2-10 l.min-1) and apply CPAP (0-30 cmH2O) selectively to the non-ventilated lung.	Oxygen	68-74	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
7933490-1	1994	To prevent hypoxemia during one-lung anesthesia, we have devised an oxygen insufflation machine which can insufflate oxygen (0.2-10 l.min-1) and apply CPAP (0-30 cmH2O) selectively to the non-ventilated lung.	Oxygen	117-123	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
7999923-5	1994	Since hypoxia occurs normally in most solid tumors, these results are interesting because they suggest a disadvantageous inhibition of the cytotoxic effects of TNF in vivo in hypoxic tissues and confirm that oxygen-dependent metabolic processes or free radicals are required to exert TNF-induced cytotoxicity.	Oxygen	208-214	tumor necrosis factor	Mus musculus	160-163
7999923-5	1994	Since hypoxia occurs normally in most solid tumors, these results are interesting because they suggest a disadvantageous inhibition of the cytotoxic effects of TNF in vivo in hypoxic tissues and confirm that oxygen-dependent metabolic processes or free radicals are required to exert TNF-induced cytotoxicity.	Oxygen	208-214	tumor necrosis factor	Mus musculus	284-287
7519855-6	1994	This study suggests that H2O2 is not directly involved in NO synthesis and that the H2O2/catalase stimulation of NO synthase activity may be due to the excess oxygen produced by the H2O2/catalase system.	Oxygen	159-165	catalase	Rattus norvegicus	84-97
8031841-5	1994	However, the hydroquinone formed proved to be unstable in the presence of oxygen, since reduction of cyclized norepinephrine o-quinone by DT-diaphorase was accompanied by continuous oxidation of NADH and oxygen consumption.	Oxygen	74-80	NAD(P)H quinone dehydrogenase 1	Homo sapiens	138-151
8022811-0	1994	Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3" enhancer.	Oxygen	0-6	lactate dehydrogenase A	Homo sapiens	71-94
8022811-0	1994	Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3" enhancer.	Oxygen	0-6	erythropoietin	Homo sapiens	124-138
8022811-2	1994	The implication of this finding is that many cells which do not produce Epo contain a similar, if not identical, oxygen-regulated control system, suggesting that the same system is involved in the regulation of other genes.	Oxygen	113-119	erythropoietin	Homo sapiens	72-75
8055908-8	1994	The NH2-terminal-side EF-hand contained a notable defect in one of the five oxygen-containing amino acid side chains involved in chelating Ca2+, suggesting that the lower Ca2+ sensitivity of the lung alpha-actinin is ascribable to this defect.	Oxygen	76-82	actinin, alpha 4	Gallus gallus	200-213
8031841-5	1994	However, the hydroquinone formed proved to be unstable in the presence of oxygen, since reduction of cyclized norepinephrine o-quinone by DT-diaphorase was accompanied by continuous oxidation of NADH and oxygen consumption.	Oxygen	204-210	NAD(P)H quinone dehydrogenase 1	Homo sapiens	138-151
8031841-6	1994	Addition of the chelator DETAPAC or SOD to the incubation mixture during reduction of cyclized norepinephrine ortho-quinone by DT-diaphorase strongly inhibited NADPH oxidation and oxygen consumption, suggesting that manganese and superoxide radicals were involved in hydroquinone autoxidation.	Oxygen	180-186	superoxide dismutase 1	Homo sapiens	25-39
8031841-6	1994	Addition of the chelator DETAPAC or SOD to the incubation mixture during reduction of cyclized norepinephrine ortho-quinone by DT-diaphorase strongly inhibited NADPH oxidation and oxygen consumption, suggesting that manganese and superoxide radicals were involved in hydroquinone autoxidation.	Oxygen	180-186	NAD(P)H quinone dehydrogenase 1	Homo sapiens	127-140
8031841-7	1994	Elimination of the effects of superoxide radicals, manganese and H2O2 on autoxidation of hydroquinone by addition of SOD, catalase and DETAPAC to the incubation mixture resulted in a 79% inhibition of NADH oxidation, suggesting that 21% of the autoxidation is oxygen-dependent.	Oxygen	260-266	superoxide dismutase 1	Homo sapiens	117-120
8020609-3	1994	Low oxygen tension decreased the number of binding sites of both EGF (mean = 44%) and TGF-beta (mean = 33%).	Oxygen	4-10	transforming growth factor beta 1	Homo sapiens	86-94
7519401-6	1994	Cheek cells exhibited a low endogenous rate of oxygen consumption, which was stimulated by glucose or succinate and inhibited by KCN or NaF.	Oxygen	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
8020609-6	1994	We conclude that low oxygen tension decreases EGF and TGF-beta receptor binding and synthesis.	Oxygen	21-27	transforming growth factor beta 1	Homo sapiens	54-62
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	21-27	transforming growth factor beta 1	Homo sapiens	54-62
8005801-1	1994	PURPOSE: Investigations were undertaken to study the influence of oxygen levels on tumor necrosis factor [symbol: see text] (TNF [symbol: see text] toxicity in vitro.	Oxygen	66-72	tumor necrosis factor	Mus musculus	125-128
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	83-89	transforming growth factor beta 1	Homo sapiens	54-62
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	83-89	transforming growth factor beta 1	Homo sapiens	54-62
8207432-5	1994	The addition of superoxide dismutase with catalase or the addition of deferoxamine mesylate inhibited PC12h cell death, suggesting that active oxygen species derived from superoxide generated by the microglia or iron-oxygen complex formation were responsible for the cytotoxicity.	Oxygen	143-149	catalase	Rattus norvegicus	42-50
8028518-4	1994	The increase in GPD activity and the resultant increase in the flow through the glycerol phosphate shuttle might be related to the increase of postburn mitochondrial oxygen consumption.	Oxygen	166-172	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	16-19
8207006-1	1994	A series of farnesylcysteine analogs was studied with respect to their abilities to interfere with fMet-Leu-Phe (fMLP)-stimulated superoxide (O2-.)	Oxygen	142-144	formyl peptide receptor 1	Homo sapiens	113-117
8005801-6	1994	RESULTS: By preincubating L929 cells under various oxygen conditions for 24 h prior to incubating with TNF [symbol: see text], we show that pretreatment does influence TNF [symbol: see text] cytotoxicity since up to 50 times more TNF [symbol: see text] is required to elicit the same survival level when L929 cells have been preincubated for 24 h at oxygen levels relevant to those in solid tumors, that is 2% rather than at 21%.	Oxygen	51-57	tumor necrosis factor	Mus musculus	168-171
8005801-6	1994	RESULTS: By preincubating L929 cells under various oxygen conditions for 24 h prior to incubating with TNF [symbol: see text], we show that pretreatment does influence TNF [symbol: see text] cytotoxicity since up to 50 times more TNF [symbol: see text] is required to elicit the same survival level when L929 cells have been preincubated for 24 h at oxygen levels relevant to those in solid tumors, that is 2% rather than at 21%.	Oxygen	51-57	tumor necrosis factor	Mus musculus	168-171
8005801-6	1994	RESULTS: By preincubating L929 cells under various oxygen conditions for 24 h prior to incubating with TNF [symbol: see text], we show that pretreatment does influence TNF [symbol: see text] cytotoxicity since up to 50 times more TNF [symbol: see text] is required to elicit the same survival level when L929 cells have been preincubated for 24 h at oxygen levels relevant to those in solid tumors, that is 2% rather than at 21%.	Oxygen	350-356	tumor necrosis factor	Mus musculus	168-171
8005801-6	1994	RESULTS: By preincubating L929 cells under various oxygen conditions for 24 h prior to incubating with TNF [symbol: see text], we show that pretreatment does influence TNF [symbol: see text] cytotoxicity since up to 50 times more TNF [symbol: see text] is required to elicit the same survival level when L929 cells have been preincubated for 24 h at oxygen levels relevant to those in solid tumors, that is 2% rather than at 21%.	Oxygen	350-356	tumor necrosis factor	Mus musculus	168-171
8005801-9	1994	Indeed cells cultured for five passages under 5% oxygen levels are approximately 50 times more resistant to TNF [symbol: see text] than cells cultured under 21% oxygen.	Oxygen	49-55	tumor necrosis factor	Mus musculus	108-111
8005801-11	1994	CONCLUSION: The oxygen content of the cellular microenvironment has a profound influence on the cytotoxic action of TNF.	Oxygen	16-22	tumor necrosis factor	Mus musculus	116-119
8048768-7	1994	Therefore, thrombin formation occurs, especially in the microcirculation, where fibrin clot deposition begins to cause inhomogeneities of blood flow and thus to reduce oxygen delivery to the tissues.	Oxygen	168-174	coagulation factor II, thrombin	Homo sapiens	11-19
8016510-1	1994	Erythropoietin is a hormone whose production is stimulated by all forms of oxygen deficiency.	Oxygen	75-81	erythropoietin	Homo sapiens	0-14
8016510-4	1994	A thoroughly controlled feedback-mechanism between oxygen-supply erythropoietin release and renewal of erythrocytes provides for a constant level of erythrocytes in blood.	Oxygen	51-57	erythropoietin	Homo sapiens	65-79
7942055-3	1994	Cycling was performed for 22.7 +/- 2.7 min (mean, SE) (fatigue) and oxygen uptake (VO2) increased to 1.90 +/- 0.13 1 min-1.	Oxygen	68-74	CD59 molecule (CD59 blood group)	Homo sapiens	117-122
8023930-3	1994	We infused insulin under nonhypoglycemic conditions and evaluated its effect on endoneurial oxygen tension, nerve blood flow, and the oxyhemoglobin dissociation curve of peripheral nerve in normal and diabetic rats.	Oxygen	92-98	insulin	Homo sapiens	11-18
8023930-4	1994	Intravenous insulin infusion resulted in a dose-dependent reduction in endoneurial oxygen tension in normal nerves (from 26% at 0.04 U/kg insulin to 55% at 32 U/kg).	Oxygen	83-89	insulin	Homo sapiens	12-19
8023930-7	1994	Diabetes or insulin administration resulted in only minimal and physiologically insignificant alterations in the oxygen dissociation curve and 2,3-diphosphoglycerate of sciatic nerve.	Oxygen	113-119	insulin	Homo sapiens	12-19
8000856-2	1994	The co-immobilization of glycolate oxidase and catalase on oxirane acrylic beads produced a catalyst which was stable to the reaction conditions used for the oxidation, where glycolic acid and oxygen are reacted in aqueous solution in the presence of the immobilized enzyme catalyst and ethylenediamine.	Oxygen	193-199	hydroxyacid oxidase 2	Homo sapiens	25-42
8000856-2	1994	The co-immobilization of glycolate oxidase and catalase on oxirane acrylic beads produced a catalyst which was stable to the reaction conditions used for the oxidation, where glycolic acid and oxygen are reacted in aqueous solution in the presence of the immobilized enzyme catalyst and ethylenediamine.	Oxygen	193-199	catalase	Homo sapiens	47-55
8085501-9	1994	During progressive treadmill tests, the heart rate interpolated to oxygen consumptions of 10 and 15 ml.kg-1.min-1 had CV = 4% and 7%, respectively.	Oxygen	67-73	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
7518321-11	1994	Treatment with both oxygen and subcutaneous sumatriptan reduced the CGRP level to normal, while opiate administration did not alter the peptide levels.	Oxygen	20-26	calcitonin related polypeptide alpha	Homo sapiens	68-72
7934213-0	1994	Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans.	Oxygen	60-66	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	84-89
7934213-1	1994	Mutations in mev-1 of the nematode Caenorhabditis elegans render animals hypersensitive to high oxygen concentrations.	Oxygen	96-102	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	13-18
8004661-0	1994	[Erythropoietin secretion in patients with chronic obstructive lung diseases during normobaric oxygen inhalation].	Oxygen	95-101	erythropoietin	Homo sapiens	1-15
8004661-5	1994	Oxygen breathing was followed by a significant decline of plasma EPO levels both in patients with COPD as in the control group.	Oxygen	0-6	erythropoietin	Homo sapiens	65-68
8004661-10	1994	The renal oxygen sensor function involved in the regulation of EPO secretion seems to be altered in COPD patients.	Oxygen	10-16	erythropoietin	Homo sapiens	63-66
8194586-5	1994	The enhancement of the formation of reactive oxygen metabolites by VIP may be important in the pathology of VIP-producing tissues.	Oxygen	45-51	vasoactive intestinal peptide	Homo sapiens	67-70
8194586-5	1994	The enhancement of the formation of reactive oxygen metabolites by VIP may be important in the pathology of VIP-producing tissues.	Oxygen	45-51	vasoactive intestinal peptide	Homo sapiens	108-111
8195022-13	1994	This reduction product is oxygen sensitive but a similar degree of activation is obtained under aerobic conditions in cell lines with high levels of 2-electron reducing DT-diaphorase.	Oxygen	26-32	NAD(P)H quinone dehydrogenase 1	Homo sapiens	169-182
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-8
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-42
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	86-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	149-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-8
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	149-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-42
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	149-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	149-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
8175769-9	1994	Cyt P450 Fe3+ is reduced by NADPH-cyt P450 reductase to cyt P450 Fe2+, which consumes oxygen in a stoichiometric proportion to produce cyt P450 Fe2+ O2, the resonance form of which is a perferryl moiety, cyt P450 Fe3+.O2-..	Oxygen	149-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-64
7915938-1	1994	The purpose of the present experiment was to clarify the interaction between food intake and activity of the thermogenic component of the sympathetic nervous system by studying the dose response relationships of typical beta 1-, beta 2-, and beta 3-adrenoceptor agonists on oxygen consumption and food intake.	Oxygen	274-280	adrenoceptor beta 1	Rattus norvegicus	220-261
7515050-1	1994	Nitric oxide synthase (NOS) catalyzes the NADPH-dependent, Ca2+/calmodulin-dependent formation of NO and citrulline from L-arginine and molecular oxygen.	Oxygen	146-152	nitric oxide synthase 2	Homo sapiens	0-21
7515050-1	1994	Nitric oxide synthase (NOS) catalyzes the NADPH-dependent, Ca2+/calmodulin-dependent formation of NO and citrulline from L-arginine and molecular oxygen.	Oxygen	146-152	calmodulin 1	Homo sapiens	64-74
8185613-1	1994	Superoxide dismutase (SOD), which breaks down superoxide to oxygen and hydrogen peroxide, is generally considered an antioxidant enzyme.	Oxygen	60-66	superoxide dismutase 1	Homo sapiens	0-20
8185613-1	1994	Superoxide dismutase (SOD), which breaks down superoxide to oxygen and hydrogen peroxide, is generally considered an antioxidant enzyme.	Oxygen	60-66	superoxide dismutase 1	Homo sapiens	22-25
7514600-7	1994	We also, found that TGF-beta 1 was induced by O2 exposure, that TGF-beta 1 inhibited SV40T-T2 proliferation, and that TGF-beta 1 itself was a potent stimulator of IGFBP-2 expression.	Oxygen	46-48	transforming growth factor beta 1	Homo sapiens	20-30
8185094-0	1994	Use of supplemental oxygen during bystander-initiated CPR.	Oxygen	20-26	cytochrome p450 oxidoreductase	Homo sapiens	54-57
8185094-1	1994	STUDY OBJECTIVE: To evaluate the efficacy of three methods by which rescuers can breathe supplemental oxygen to increase their delivered oxygen concentration (FDO2) during single-rescuer, bystander-initiated CPR.	Oxygen	102-108	cytochrome p450 oxidoreductase	Homo sapiens	208-211
8179317-6	1994	These complexes prevented the reduction of cytochrome c by O2- but were less active than free Mn(II).	Oxygen	59-61	cytochrome c, somatic	Homo sapiens	43-55
8185094-1	1994	STUDY OBJECTIVE: To evaluate the efficacy of three methods by which rescuers can breathe supplemental oxygen to increase their delivered oxygen concentration (FDO2) during single-rescuer, bystander-initiated CPR.	Oxygen	137-143	cytochrome p450 oxidoreductase	Homo sapiens	208-211
8185094-11	1994	CONCLUSION: The use of supplemental oxygen increases the rescuer"s FDO2 during ventilation-only and full CPR without interfering with CPR performance.	Oxygen	36-42	cytochrome p450 oxidoreductase	Homo sapiens	105-108
8081209-0	1994	TNF-alpha effect on oxygen free radical scavenging and generating enzymes in rat liver.	Oxygen	20-26	tumor necrosis factor	Rattus norvegicus	0-9
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	74-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-56
8179325-4	1994	Further, experiments using [18O]mCPBA and 18O2 proved that the cleavage reaction is accompanied with the ipso-substitution by the oxygen atom of the active species in both cytochrome P450 model system and cytochrome P450.	Oxygen	130-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	172-187
8179325-4	1994	Further, experiments using [18O]mCPBA and 18O2 proved that the cleavage reaction is accompanied with the ipso-substitution by the oxygen atom of the active species in both cytochrome P450 model system and cytochrome P450.	Oxygen	130-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	205-220
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	74-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-190
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	74-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-190
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	138-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-56
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	138-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-190
8179325-0	1994	Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.	Oxygen	138-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-190
8071611-12	1994	IFN-gamma at concentrations that maximally inhibit LDL oxidation stimulated the phorbol myristate acetate (PMA)-induced production of O2- 1.4-times greater than control cells after one hour.	Oxygen	134-136	interferon gamma	Mus musculus	0-9
8174673-4	1994	Therapy with IFN-alpha resulted in significantly diminished values for oxygen species (NaF stimulation) and LTB4 (FMLP stimulation) generation, as well as FMLP receptor expression as compared to untreated CML.	Oxygen	71-77	interferon alpha 1	Homo sapiens	13-22
7513993-1	1994	To create a semi-artificial monomolecular oxygenase system, FAD or FMN were covalently bound to cytochrome P450 2B4 as electron donor centers and bleomycin to NADPH-cytochrome P450 reductase as a generator of active oxygen species.	Oxygen	42-48	cytochrome p450 oxidoreductase	Homo sapiens	159-190
7937273-0	1994	Effect of long-term angiotensin-converting enzyme inhibitor therapy on arterial oxygen saturation in patients with mild to moderate heart failure.	Oxygen	80-86	angiotensin I converting enzyme	Homo sapiens	20-49
8091005-1	1994	To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
8091005-1	1994	To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
8091005-4	1994	These findings suggest that IL-8 activates neutrophils, which produce active oxygen.	Oxygen	77-83	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8179604-5	1994	USA (1994) in press) that beta-amyloid peptide fragments in aqueous media, in a metal-independent reaction, produce reactive peptide free radicals and reactive oxygen species.	Oxygen	160-166	amyloid beta precursor protein	Homo sapiens	26-46
8039809-3	1994	Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P &lt; 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro.	Oxygen	139-141	interferon gamma	Homo sapiens	28-37
8148375-7	1994	These findings support the existence of a widespread oxygen sensing system in mammalian cells which is similar to that operating in specific cells to regulate erythropoietin production, and they indicate that the system activates factors with similar DNA sequence specificity in different cells.	Oxygen	53-59	erythropoietin	Homo sapiens	159-173
8168518-6	1994	In both cases a time-dependent loss of the characteristic charge-transfer absorbance band at 530 nm is observed upon addition of arsenical to pre-reduced enzyme, which with excess NADPH leads to a spectrum resembling the EH4 form and is accompanied by an increased ability to reduce molecular oxygen.	Oxygen	293-299	epoxide hydrolase 4	Homo sapiens	221-224
8036904-4	1994	The maximal leg oxygen uptake was 0.72 +/- 0.07 l min-1 (0.33 +/- 0.03 l kg-1 min-1).	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	50-55
8036904-4	1994	The maximal leg oxygen uptake was 0.72 +/- 0.07 l min-1 (0.33 +/- 0.03 l kg-1 min-1).	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
8039809-3	1994	Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P &lt; 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro.	Oxygen	352-354	interferon gamma	Homo sapiens	28-37
8132519-8	1994	The ability of L-lactate to reduce the enzyme flavin is essentially abolished, whereas reoxidation of reduced enzyme with oxygen proceeds at 1.4 x 10(4) M-1 s-1, a rate essentially like that found in the wild type enzyme.	Oxygen	122-128	tumor associated calcium signal transducer 2	Homo sapiens	153-160
7911791-6	1994	In patients with very high systolic blood pressures during exercise and those with impaired oxygen delivery to the heart during exercise beta 1-selective blockers may have advantages over other antihypertensive agents, since they very effectively reduce systolic blood pressure and heart rate during exercise.	Oxygen	92-98	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	137-143
8084323-6	1994	These results support the view that interferon gamma may benefit these subjects by influencing oxygen-independent antimicrobial activity or other immunological parameters.	Oxygen	95-101	interferon gamma	Homo sapiens	36-52
8146329-1	1994	In this study, we have shown that steady-state levels of glucose-regulated 78 kDa (GRP78) protein and messenger RNA increase during a 5-h exposure to 0.02% oxygen.	Oxygen	156-162	heat shock protein family A (Hsp70) member 5	Homo sapiens	83-88
8137243-2	1994	In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.	Oxygen	65-67	NFKB inhibitor alpha	Homo sapiens	80-95
8137243-2	1994	In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.	Oxygen	65-67	nuclear factor kappa B subunit 1	Homo sapiens	119-129
8137243-2	1994	In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.	Oxygen	65-67	nuclear factor kappa B subunit 1	Homo sapiens	216-226
8160198-1	1994	N-Morpholino-N-nitrosoaminoacetonitrile (SIN-1), a nitrovasodilator metabolite of the drug, molsidomine, is widely used in studies on the pharmacology and toxicology of nitric oxide (NO) because solutions of SIN-1 "spontaneously" release NO in a pathway involving molecular oxygen.	Oxygen	274-280	MAPK associated protein 1	Homo sapiens	41-46
8147902-3	1994	An intermediate of isoniazid reduced ferric MPO to ferrous MPO which associated with dioxygen to form compound III.	Oxygen	85-93	myeloperoxidase	Homo sapiens	44-47
8147902-3	1994	An intermediate of isoniazid reduced ferric MPO to ferrous MPO which associated with dioxygen to form compound III.	Oxygen	85-93	myeloperoxidase	Homo sapiens	59-62
8147902-11	1994	In addition, phytic acid also facilitated compound III decay in the absence of isoniazid, suggesting that it may also regulate the oxygen affinity of MPO, similar to its effect on the oxygenation of haemoglobin.	Oxygen	131-137	myeloperoxidase	Homo sapiens	150-153
8197084-2	1994	Improvement of common parameters of compensation during optimization of insulin therapy and therapeutic diets was associated with approximation of substrate oxidation structure and energetic structure of a diet, as well as with increased production of useful energy coupled with reduced oxygen consumption.	Oxygen	287-293	insulin	Homo sapiens	72-79
9371269-2	1994	Erythropoietin is secreted by the kidney in response to decreased blood oxygen.	Oxygen	72-78	erythropoietin	Homo sapiens	0-14
8177196-8	1994	These results suggest that postoperative PMN signal transduction mechanisms, mediated by protein kinase C, may activate myeloperoxidase-H2-O2-halide system but suppress NADPH oxidase system dependently of the degree of surgical stress, revealing a differential effect of protein kinase C activation on PMN microbicidal activity.	Oxygen	139-141	myeloperoxidase	Homo sapiens	120-135
8113548-10	1994	CONCLUSIONS: Angiotensin-converting enzyme inhibition lessens exercise-induced ischemia in patients with syndrome X and microvascular angina, probably by a direct modulation of coronary microvascular tone, which results in an increased myocardial oxygen supply.	Oxygen	247-253	angiotensin I converting enzyme	Homo sapiens	13-42
8120449-1	1994	The formation of oxygen-derived radicals by phagocytes is regulated by chemotactic agents, cytokines, and adhesion molecules, such as CD11b/CD18 (Mac-1).	Oxygen	17-23	integrin subunit alpha M	Rattus norvegicus	134-139
8120449-1	1994	The formation of oxygen-derived radicals by phagocytes is regulated by chemotactic agents, cytokines, and adhesion molecules, such as CD11b/CD18 (Mac-1).	Oxygen	17-23	integrin subunit beta 2	Rattus norvegicus	140-144
8308005-0	1994	Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.	Oxygen	25-31	vascular endothelial growth factor A	Homo sapiens	80-114
8123012-3	1994	The human RBC PRP (HRPRP) completely inhibited visible absorption spectral changes of oxyhemoglobin, DNA cleavage, and the peroxidation of RBC membrane by a nonenzymatic Fe3+/O2/thiol mixed-function oxidation system capable of generating hydroxyl radical.	Oxygen	175-177	prion protein	Homo sapiens	14-17
8117296-6	1994	These data show that oxygen radical treatment converts acetylcholinesterase to a partially unfolded state, which retains most of its secondary structure but lacks substantial tertiary structure, thus resembling a "molten globule" state.	Oxygen	21-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-75
8313977-2	1994	It revealed that Tris at micromolar concentrations decreases the oxygen pressure at half-saturation (p50) by a factor of more than two, whereas chloride does not influence oxygen affinity.	Oxygen	65-71	nuclear factor kappa B subunit 1	Homo sapiens	101-104
8308005-0	1994	Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.	Oxygen	25-31	erythropoietin	Homo sapiens	119-133
8308005-5	1994	In this report we demonstrate multiple similarities between the oxygen-sensing mechanisms regulating the expression of VEGF and Epo.	Oxygen	64-70	vascular endothelial growth factor A	Homo sapiens	119-123
8308005-5	1994	In this report we demonstrate multiple similarities between the oxygen-sensing mechanisms regulating the expression of VEGF and Epo.	Oxygen	64-70	erythropoietin	Homo sapiens	128-131
8148419-0	1994	Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity.	Oxygen	131-137	BCL2 related protein A1	Homo sapiens	69-83
8117326-7	1994	The addition of superoxide dismutase (SOD) and catalase in the auto-oxidation experiments each decreased the rate of oxygen consumption, indicating that O2- and H2O2 are generated during auto-oxidation.	Oxygen	117-123	superoxide dismutase 1	Homo sapiens	38-41
8117326-8	1994	In the CN(-)-stimulated oxidation experiments, the addition of SOD also slowed the rate of oxygen consumption.	Oxygen	91-97	superoxide dismutase 1	Homo sapiens	63-66
8300568-0	1994	Modeling the sequence of electron transfer reactions in the single turnover of reduced, mammalian cytochrome c oxidase with oxygen.	Oxygen	124-130	cytochrome c, somatic	Homo sapiens	98-110
8157369-3	1994	Erythropoiesis is controlled by the hormone erythropoietin, which induces slow changes of the O2-transport capacity.	Oxygen	94-96	erythropoietin	Homo sapiens	44-58
16727409-9	1994	Our results suggest that oxidative injury may be responsible for developmental retardation of preimplantation-stage mouse embryos in vitro and that Cu,Zn-SOD may play a crucial role in protecting embryos against oxygen toxicity in vivo as well as in vitro.	Oxygen	212-218	superoxide dismutase 1, soluble	Mus musculus	148-157
8209340-11	1994	This implies that the extra insulin supplied was caused by physically dissolved nitrogen and oxygen in the insulin solution, and was not due to dysfunction of the pumps.	Oxygen	93-99	insulin	Homo sapiens	28-35
8209340-11	1994	This implies that the extra insulin supplied was caused by physically dissolved nitrogen and oxygen in the insulin solution, and was not due to dysfunction of the pumps.	Oxygen	93-99	insulin	Homo sapiens	107-114
7910381-7	1994	Glutamine synthetase activity was dependent on FBP added during the 22 hours of either normoxic- or hypoxic-treatment, hence significant increases in activity were observed due to FBP regardless of the oxygen/ATP levels in situ.	Oxygen	202-208	glutamate-ammonia ligase	Homo sapiens	0-20
8300568-1	1994	Single-turnover studies of the reaction of reduced cytochrome oxidase with oxygen has led to a mechanistic model that specifies a linear sequence of electron transfer from cytochrome c to O2 via the four redox active metals of mitochondrial cytochrome oxidase.	Oxygen	75-81	cytochrome c, somatic	Homo sapiens	172-184
8300568-1	1994	Single-turnover studies of the reaction of reduced cytochrome oxidase with oxygen has led to a mechanistic model that specifies a linear sequence of electron transfer from cytochrome c to O2 via the four redox active metals of mitochondrial cytochrome oxidase.	Oxygen	188-190	cytochrome c, somatic	Homo sapiens	172-184
8974327-5	1994	In addition, CYP2E1 has a unique capacity to reduce dioxygen to reactive oxy radicals that might initiate membranous lipid peroxidation, yielding products, mainly aldehydes, which activate immune cells for cytokine production and Ito cells for collagen formation.	Oxygen	52-60	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	13-19
7847075-12	1994	The specificity of the oxygen radical effects was tested in experiments using the oxygen radical scavengers catalase and superoxide dismutase.	Oxygen	23-29	catalase	Rattus norvegicus	108-116
8079738-0	1994	Use of the hypertensive agent angiotensin II for modifying oxygen delivery to tumours.	Oxygen	59-65	angiotensinogen	Homo sapiens	30-44
8092761-4	1994	There were no correlations between plasma ET-1 and vascular pressures, but there was a significant association between ET-1 and the requirement of supplemental oxygen and the arterial-alveolar oxygen tension ratio.	Oxygen	160-166	endothelin 1	Homo sapiens	119-123
8304468-5	1994	The endotoxin-induced O2 tolerance was associated with a selective enhancement of pulmonary manganese superoxide dismutase, but not Cu,Zn SOD, mRNA.	Oxygen	22-24	superoxide dismutase 1	Rattus norvegicus	132-141
8092761-4	1994	There were no correlations between plasma ET-1 and vascular pressures, but there was a significant association between ET-1 and the requirement of supplemental oxygen and the arterial-alveolar oxygen tension ratio.	Oxygen	193-199	endothelin 1	Homo sapiens	119-123
8012290-8	1994	The results demonstrate that like rodents and lagomorphs, the hepatic microsomal NADPH cytochrome c reductase in nonhuman primate, Macaca mulatta can carry out single electron reduction of molecular oxygen.	Oxygen	199-205	LOC106992390	Macaca mulatta	87-99
7994399-9	1994	The effect of HbO2 p50 on oxygen release during the passage of blood through a capillary bed, generally judged on the basis of percentage percent saturation at "tissue pO2", should be judged on the basis of the change in pO2 (the diffusion driving force) associated with a particular degree of HbO2 saturation at a particular p50.	Oxygen	26-32	nuclear factor kappa B subunit 1	Homo sapiens	19-22
8110542-4	1994	All control oxygen responses were biphasic: the acute hypoxic response was 7.2 (4.6) litre min-1 and the subsequent decline 4.2 (2.6) litre min-1.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
7986477-2	1994	In addition to oxygen delivery, oxygen consumption may be important in stimulating EPO production.	Oxygen	15-21	erythropoietin	Homo sapiens	83-86
7986477-2	1994	In addition to oxygen delivery, oxygen consumption may be important in stimulating EPO production.	Oxygen	32-38	erythropoietin	Homo sapiens	83-86
8281647-6	1994	Maximal O2 uptake (VO2max) was 50.4 +/- 1.7 mL.kg-1 x min-1 in the MA and 29.6 +/- 1.4 mL.kg-1 x min-1 (P = .0001) in controls.	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
7922625-6	1994	The reduced activity of SOD and CAT after application of vitamin E indicates an inhibition of the formation of active oxygen species in gastric mucosa.	Oxygen	118-124	catalase	Homo sapiens	32-35
7987973-5	1994	The ability of catalase and superoxide dismutase to abolish completely the increase in cytotoxicity produced by laser irradiation suggests that the cytotoxic mechanism may depend on the generation of active oxygen species by the photodynamically excited drug.	Oxygen	207-213	catalase	Mus musculus	15-23
7528597-2	1994	Recent findings suggest that the VEGF gene utilizes an oxygen sensing mechanism similar to the one used by the erythropoietin gene.	Oxygen	55-61	vascular endothelial growth factor A	Homo sapiens	33-37
7528597-2	1994	Recent findings suggest that the VEGF gene utilizes an oxygen sensing mechanism similar to the one used by the erythropoietin gene.	Oxygen	55-61	erythropoietin	Homo sapiens	111-125
7976643-6	1994	Continuous monitoring of the jugular venous oxygen saturation and BTT/TMT was effective for evaluating cerebral ischemia and oxygen metabolic disturbances even during cerebral hypothermia treatment.	Oxygen	125-131	tryptase gamma 1	Homo sapiens	70-73
7950169-5	1994	The mechanism by which lack of oxygen induces erythropoietin gene expression is only partly understood.	Oxygen	31-37	erythropoietin	Homo sapiens	46-60
8276352-9	1994	Oxygen saturation of blood in sinusoids was decreased in a dose-dependent manner, reaching values around 40% of control with 1,000 pmol/kg endothelin-1.	Oxygen	0-6	endothelin 1	Rattus norvegicus	139-151
7867993-2	1994	They are derived from the following equation: [formula: see text] The first parameter, beta 1,0, reflects the oxygen capacity of the curve within the range of 1.0 kPa at its "arterial section".	Oxygen	110-116	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	87-93
8082573-6	1994	Certain amines appear to regulate O2 association with cytochrome P-450 and stabilize the various oxy species formed.	Oxygen	34-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-70
8082573-8	1994	Small differences in protein structure between the various cytochrome P-450 subforms might serve to stabilize aminium radicals to permit oxygen rebound.	Oxygen	137-143	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-75
8276367-10	1994	The lower reduction in gastric mucosal oxygen content observed with glypressin could decrease the incidence of ischemic adverse events associated with the use of vasopressin.	Oxygen	39-45	arginine vasopressin	Homo sapiens	162-173
8150558-2	1994	OK-432 increased O2- generation was also observed when PMN were cultured with 10(-2)KE/ml OK-432 for 1 h and then stimulated with phorbol myristate acetate or formyl-metionyl-leucil-phenylalanine (FMLP).	Oxygen	17-19	formyl peptide receptor 1	Homo sapiens	197-201
8157949-6	1994	There was a positive correlation between insulin sensitivity and maximal oxygen uptake in both groups.	Oxygen	73-79	insulin	Homo sapiens	41-48
7532995-5	1994	With films deposited using oxygen-containing monomers, the initial attachment and spreading of endothelial cells failed when the medium contained 15% (v/v) serum from which both fibronectin (Fn) and vitronectin (Vn) had been removed.	Oxygen	27-33	fibronectin 1	Homo sapiens	178-189
7532995-5	1994	With films deposited using oxygen-containing monomers, the initial attachment and spreading of endothelial cells failed when the medium contained 15% (v/v) serum from which both fibronectin (Fn) and vitronectin (Vn) had been removed.	Oxygen	27-33	fibronectin 1	Homo sapiens	191-193
7532995-6	1994	Similarly, initial attachment and spreading of endothelial cells onto films deposited using oxygen-containing monomers were reduced by 62-86% when the cells were seeded in medium containing Vn-depleted serum (which contained Fn).	Oxygen	92-98	fibronectin 1	Homo sapiens	225-227
7532995-9	1994	Furthermore, surfaces which had incorporated nitrogen were more effective than were oxygen-containing films in adsorbing sufficient serum Fn as to promote endothelial cell attachment.	Oxygen	84-90	fibronectin 1	Homo sapiens	138-140
7519693-0	1994	ACE inhibition and physical exercise: studies on physical work capacity, energy metabolism, and maximum oxygen uptake in well-trained, healthy subjects.	Oxygen	104-110	angiotensin I converting enzyme	Homo sapiens	0-3
7967206-7	1994	The results of this study indicate that the localization and production of active oxygen change during the development of the mouse retina, and that SOD activity does exist in the retina from birth, increasing as its role in the protective system against active oxygen increases in the maturing mouse retina.	Oxygen	262-268	superoxide dismutase 1, soluble	Mus musculus	149-152
8139733-0	1994	Effect of recombinant human erythropoietin treatment in uremic patients on oxygen affinity of hemoglobin.	Oxygen	75-81	erythropoietin	Homo sapiens	28-42
8007764-0	1994	Effect of metallothionein I on mitochondrial oxygen consumption.	Oxygen	45-51	metallothionein 1	Rattus norvegicus	10-27
8007764-1	1994	The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied.	Oxygen	84-90	metallothionein 1	Rattus norvegicus	57-74
8007764-1	1994	The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied.	Oxygen	84-90	metallothionein 1	Rattus norvegicus	76-78
8007764-2	1994	Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT.	Oxygen	19-25	metallothionein 1	Rattus norvegicus	110-112
8007764-2	1994	Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT.	Oxygen	19-25	metallothionein 1	Rattus norvegicus	171-173
8007764-2	1994	Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT.	Oxygen	87-93	metallothionein 1	Rattus norvegicus	110-112
8007764-2	1994	Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT.	Oxygen	87-93	metallothionein 1	Rattus norvegicus	110-112
8139733-2	1994	It has been reported that the correction of renal anemia by recombinant human erythropoietin (rhuEPO) treatment could be associated paradoxically with a further decrease in Hb-O2 affinity.	Oxygen	176-178	erythropoietin	Homo sapiens	78-92
7969677-0	1994	Erythropoietin secretion in patients with chronic renal failure after pure oxygen breathing.	Oxygen	75-81	erythropoietin	Homo sapiens	0-14
7969677-4	1994	Pure oxygen breathing was followed by a significant decline of plasma EPO levels both in patients with chronic renal failure and in the control group.	Oxygen	5-11	erythropoietin	Homo sapiens	70-73
8052371-0	1994	Erythropoietin: oxygen-dependent control of erythropoiesis and its failure in renal disease.	Oxygen	16-22	erythropoietin	Homo sapiens	0-14
7838895-4	1994	Catalase (Cat), diethylenetriaminepentaacetic acid (DETAPAC), desferroxiamine (Desferal), dimethyl sulfoxide (DMSO) and ethanol (EtOH) all inhibited 60-80% of DNA damage by the generated O2-.. Superoxide dismutase (SOD) inhibited all DNA damages by O2-.. Cat, DETAPAC and Desferal effectively inhibited DNA break by .OH; complete inhibition of .OH-induced DNA break was achieved by addition of DMSO and EtOH.	Oxygen	187-189	catalase	Homo sapiens	0-8
7838895-4	1994	Catalase (Cat), diethylenetriaminepentaacetic acid (DETAPAC), desferroxiamine (Desferal), dimethyl sulfoxide (DMSO) and ethanol (EtOH) all inhibited 60-80% of DNA damage by the generated O2-.. Superoxide dismutase (SOD) inhibited all DNA damages by O2-.. Cat, DETAPAC and Desferal effectively inhibited DNA break by .OH; complete inhibition of .OH-induced DNA break was achieved by addition of DMSO and EtOH.	Oxygen	187-189	catalase	Homo sapiens	0-3
7800957-8	1994	A negative correlation was found between arterial oxygen pressure and ET-1 excretion; no correlation was found between plasma and urinary ET-1 values.	Oxygen	50-56	endothelin 1	Homo sapiens	70-74
7941678-7	1994	Furthermore, chronic decrease in filling pressures by administration of diuretics, nitrates, ACE-inhibitors or dopaminergic drugs leads to long-term improvement in oxygen uptake.	Oxygen	164-170	angiotensin I converting enzyme	Homo sapiens	93-96
8299948-0	1993	The 3" flanking region of the human erythropoietin-encoding gene contains nitrogen-regulatory/oxygen-sensing consensus sequences and tissue-specific transcriptional regulatory elements.	Oxygen	94-100	erythropoietin	Homo sapiens	36-50
8267628-1	1993	The effect of hyperoxia (O2 &gt; 95%) for 48 hours on the induction of pulmonary and hepatic cytochrome P450 has been investigated in adult male rats.	Oxygen	25-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-108
8265621-1	1993	Human cytochrome P450 3A4 is recognized as the catalyst for the oxygen-dependent metabolism of a diverse group of medically important chemicals, including the immunosuppressive agent cyclosporin; macrolide antibiotics, such as erythromycin; drugs such as benzphetamine, nifedipine, and cocaine; and steroids; such as cortisol and testosterone to name but a few.	Oxygen	64-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-25
8128887-2	1993	Estimated maximal oxygen uptake was increased in the trained group when compared with the sedentary group (74.0 +/- 3.9 vs. 42.9 +/- 5.1 ml kg-1 min-1; P &lt; 0.01).	Oxygen	18-24	CD59 molecule (CD59 blood group)	Homo sapiens	145-150
7584476-4	1994	Oxygen radical formation by the tumour cells in the presence of TNF-alpha and radiation, alone and in combination, was also investigated.	Oxygen	0-6	tumor necrosis factor	Homo sapiens	64-73
8274159-7	1993	Experiments with catalase, superoxide dismutase and H2O2 have shown that the H2O2 or O2-, respectively, formed from the respective enzyme and the substrate, apparently participated in the reaction.	Oxygen	54-56	catalase	Homo sapiens	17-25
8267652-7	1993	Perfusion of the liver with high K+(Cl-) medium under 20% O2 markedly suppressed CCl4-induced LDH leakage even in the presence of Ca2+, whereas once CCl4 had acted under regular KHB perfusion, changing the medium to high K+ did not further prevent the LDH leakage.	Oxygen	58-60	C-C motif chemokine ligand 4	Rattus norvegicus	81-85
8267656-10	1993	It is likely that an active Fe2(+)-oxygen complex, formed via NADPH-cytochrome P450 reductase and cytochrome P450-dependent reduction of free Fe3+ followed by oxygen binding, serves as the species inducing lipid peroxidation and at least part of (S)-4-OH-OTA formation.	Oxygen	35-41	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-83
8267656-10	1993	It is likely that an active Fe2(+)-oxygen complex, formed via NADPH-cytochrome P450 reductase and cytochrome P450-dependent reduction of free Fe3+ followed by oxygen binding, serves as the species inducing lipid peroxidation and at least part of (S)-4-OH-OTA formation.	Oxygen	159-165	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-83
8281593-3	1993	The O2- production (speed and amount) was measured perioperatively using the cytochrome c reduction method.	Oxygen	4-6	cytochrome c, somatic	Homo sapiens	77-89
8267206-9	1993	Significantly higher cytochrome P-450 content was found in whole hepatocyte populations under 5% versus 20% oxygen, indicating that centrilobular hepatocytes that contained higher cytochrome P-450 monooxygenase activities were less sensitive to low oxygen concentrations.	Oxygen	108-114	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
8267206-9	1993	Significantly higher cytochrome P-450 content was found in whole hepatocyte populations under 5% versus 20% oxygen, indicating that centrilobular hepatocytes that contained higher cytochrome P-450 monooxygenase activities were less sensitive to low oxygen concentrations.	Oxygen	201-207	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
8285335-5	1993	After operation, the effect of 4 l.min-1 of oxygen by nasal catheter on PaO2 was similar in all groups.	Oxygen	44-50	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
8151136-2	1993	We tested the hypothesis that suppression of endothelial cell proliferation by IFN-gamma is mediated by an increase in xanthine oxidase-derived O2-.. Human umbilical vein endothelial cells (HUVEC) were exposed to recombinant human IFN-gamma.	Oxygen	144-146	interferon gamma	Homo sapiens	79-88
8252716-6	1993	The inhibitory effects of SOD and catalase are most likely the result of oxygen regeneration in the assay mixture.	Oxygen	73-79	superoxide dismutase 1	Homo sapiens	26-29
8138189-1	1993	In evaluating the relative expression of copper-zinc and manganese superoxide dismutase (CuZnSOD and MnSOD) in vivo in states like Down syndrome in which one dismutase is present at increased levels, we measured activities of both enzymes, in tissues of control and transgenic mice constitutively expressing increased levels of CuZnSOD, during exposure to normal and elevated oxygen tensions.	Oxygen	376-382	superoxide dismutase 1, soluble	Mus musculus	89-96
8138189-5	1993	In lung, which is the organ exposed to the highest oxygen tension during ambient hyperoxia, a sensitive, specific ELISA for MnSOD was used.	Oxygen	51-57	superoxide dismutase 2, mitochondrial	Mus musculus	124-129
8125419-7	1993	Chronic but not acute treatment with angiotensin converting enzyme (ACE) inhibitors increases blood flow to the exercising muscle and improves peak oxygen consumption.	Oxygen	148-154	angiotensin I converting enzyme	Homo sapiens	37-66
8125419-7	1993	Chronic but not acute treatment with angiotensin converting enzyme (ACE) inhibitors increases blood flow to the exercising muscle and improves peak oxygen consumption.	Oxygen	148-154	angiotensin I converting enzyme	Homo sapiens	68-71
8125422-7	1993	The ECCE trial is a randomized, seven-center investigation, studying the effects of ACE inhibition on oxygen uptake in a double blind, placebo controlled design in a group of 204 patients.	Oxygen	102-108	angiotensin I converting enzyme	Homo sapiens	84-87
8123998-10	1993	The DS had a significantly (P = 0.006) lower peak oxygen uptake (ml kg-1 min-1) as compared to the NDS group (23.68 +/- 4.01 vs 31.00 +/- 7.11, respectively).	Oxygen	50-56	CD59 molecule (CD59 blood group)	Homo sapiens	73-78
8140120-0	1993	Use of a continuous assay of oxygen consumption to evaluate the pharmacology of 5-lipoxygenase inhibitors.	Oxygen	29-35	arachidonate 5-lipoxygenase	Homo sapiens	80-94
7909954-2	1993	We found that a reduction in oxygen tension from 21% to 10% caused a substantial increase (200% at 1 hour and 500% at 6 hours exposure) in the concentration of TH mRNA in carotid body type I cells but not in either the sympathetic ganglia or adrenal gland.	Oxygen	29-35	tyrosine hydroxylase	Homo sapiens	160-162
8279224-0	1993	Acute and chronic hyperbaric oxygen exposure in humans: effects on blood polyamines, adrenocorticotropin and beta-endorphin.	Oxygen	29-35	proopiomelanocortin	Homo sapiens	109-123
7504282-5	1993	Calmodulin-triggered electron transfer to heme was independent of substrate binding, caused rapid enzymatic oxidation of NADPH in the presence of O2, and was required for NO synthesis.	Oxygen	146-148	calmodulin 1	Homo sapiens	0-10
8218263-4	1993	As the oxygen concentration approaches 20% saturation, the cytochrome c reduction by NAD is abolished first and then the reduction by hydrated electrons, since molecular oxygen competes with cytochrome c for NAD and hydrated electrons.	Oxygen	7-13	cytochrome c, somatic	Homo sapiens	59-71
8218263-4	1993	As the oxygen concentration approaches 20% saturation, the cytochrome c reduction by NAD is abolished first and then the reduction by hydrated electrons, since molecular oxygen competes with cytochrome c for NAD and hydrated electrons.	Oxygen	7-13	cytochrome c, somatic	Homo sapiens	191-203
8218263-4	1993	As the oxygen concentration approaches 20% saturation, the cytochrome c reduction by NAD is abolished first and then the reduction by hydrated electrons, since molecular oxygen competes with cytochrome c for NAD and hydrated electrons.	Oxygen	170-176	cytochrome c, somatic	Homo sapiens	59-71
8218263-5	1993	At 20% oxygen, cytochrome c is reduced almost exclusively by the superoxide anion, but the amount reduced on a single laser pulse is only one-fourth that reduced under anaerobic conditions.	Oxygen	7-13	cytochrome c, somatic	Homo sapiens	15-27
8140924-4	1993	The detection of the univalent reaction was followed by the study of oxygen consumption, in the presence of cytochrome c.	Oxygen	69-75	cytochrome c, somatic	Homo sapiens	108-120
8218216-0	1993	Role of hydrogen bonding to bound dioxygen in soybean leghemoglobin.	Oxygen	34-42	leghemoglobin A	Glycine max	54-67
8218216-7	1993	A discussion of the contribution of this hydrogen bond to the pH-dependent O2 affinity of leghemoglobin is presented.	Oxygen	75-77	leghemoglobin A	Glycine max	90-103
8279224-6	1993	These results demonstrate different modifications of polyamines and beta-endorphin and ACTH in subjects submitted to hyperbaric oxygen exposure.	Oxygen	128-134	proopiomelanocortin	Homo sapiens	68-82
8279224-6	1993	These results demonstrate different modifications of polyamines and beta-endorphin and ACTH in subjects submitted to hyperbaric oxygen exposure.	Oxygen	128-134	proopiomelanocortin	Homo sapiens	87-91
8260276-3	1993	Oxygen-haemoglobin affinity was expressed as the oxygen tension in mm Hg at which blood is 50% saturated with oxygen (P50).	Oxygen	110-116	nuclear factor kappa B subunit 1	Homo sapiens	118-121
8238479-4	1993	The rates of the production of immunoreactive Epo and lactate were high due to a misproportion between O2 supply and O2 requirements.	Oxygen	103-105	erythropoietin	Homo sapiens	46-49
8238479-4	1993	The rates of the production of immunoreactive Epo and lactate were high due to a misproportion between O2 supply and O2 requirements.	Oxygen	117-119	erythropoietin	Homo sapiens	46-49
8238479-5	1993	Epo production decreased when shaken instead of static cultures were studied, or when the O2 concentration in the gas atmosphere was increased gradually up to 95%.	Oxygen	90-92	erythropoietin	Homo sapiens	0-3
8119059-6	1993	The pulmonary oxygen uptake (VO2) was increased slightly by endothelin-1.	Oxygen	14-20	endothelin 1	Homo sapiens	60-72
8282094-2	1993	In particular, the formation of toxic oxygen metabolites via the NADPH oxidase requires the action of both Rac and Rap1A proteins.	Oxygen	38-44	AKT serine/threonine kinase 1	Homo sapiens	107-110
8227170-1	1993	Dermal fibroblasts exposed to low oxygen tension show upregulated synthesis of transforming growth factor-beta 1 (TGF-beta 1), an established stimulatory peptide in the formation of extracellular matrix proteins.	Oxygen	34-40	transforming growth factor beta 1	Homo sapiens	79-112
8293779-1	1993	This study was conducted to elucidate the role of S-adenosyl-L-homocysteine (SAH) hydrolase, 5"-nucleotidase and adenosine kinase in the production and removal of adenosine in the isolated guinea pig heart during normoxic (95% O2) and hypoxic (30% O2) perfusion.	Oxygen	227-229	adenosine kinase	Cavia porcellus	113-129
8293779-1	1993	This study was conducted to elucidate the role of S-adenosyl-L-homocysteine (SAH) hydrolase, 5"-nucleotidase and adenosine kinase in the production and removal of adenosine in the isolated guinea pig heart during normoxic (95% O2) and hypoxic (30% O2) perfusion.	Oxygen	248-250	adenosine kinase	Cavia porcellus	113-129
11767317-2	1993	The patients in the pre-oxgenated group (n = 30) received 8 litre min-1 oxygen through a plastic facemask for 3 min whereas those in a control group (n = 30) were not pre-oxygenated.	Oxygen	72-78	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
11767317-7	1993	An 8 litre min-1 oxygen flow via a standard transparent plastic facemask is a simple, feasible and acceptable method for routine pre-oxygenation for all elective cases.	Oxygen	17-23	CD59 molecule (CD59 blood group)	Homo sapiens	11-16
8227868-3	1993	IgE also inhibited oxygen consumption rate and cytochrome c reduction with similar K0.5 values.	Oxygen	19-25	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
8227170-1	1993	Dermal fibroblasts exposed to low oxygen tension show upregulated synthesis of transforming growth factor-beta 1 (TGF-beta 1), an established stimulatory peptide in the formation of extracellular matrix proteins.	Oxygen	34-40	transforming growth factor beta 1	Homo sapiens	114-124
8227170-6	1993	We conclude that low oxygen tension enhances steady state mRNA levels of alpha 1 (I) procollagen, and that this effect is mediated at least in part by TGF-beta 1.	Oxygen	21-27	transforming growth factor beta 1	Homo sapiens	151-161
8409429-9	1993	Importantly, when the generation of alpha beta T cells in submersion culture was restored by elevating oxygen concentrations, there was a dramatic increase in TCF1(alpha) activity, and both NF-kappa B and NF-Y returned to control levels.	Oxygen	103-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	190-200
7503812-2	1993	Bcl-2 is localized to intracellular sites of oxygen free radical generation including mitochondria, endoplasmic reticula, and nuclear membranes.	Oxygen	45-51	BCL2 apoptosis regulator	Homo sapiens	0-5
8246884-1	1993	In Saccharomyces cerevisiae, hypusine-containing proteins are encoded by two closely related genes, HYP1 and HYP2, which are regulated reciprocally by oxygen and heme.	Oxygen	151-157	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	100-104
7507613-2	1993	SOD clears superoxide radical and is one of the body"s principal defense mechanisms against oxygen toxicity.	Oxygen	92-98	superoxide dismutase 1	Homo sapiens	0-3
8408001-1	1993	Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2.	Oxygen	122-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8408001-1	1993	Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2.	Oxygen	122-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
8405432-0	1993	Solvent oxygen is not incorporated into N10-formyltetrahydrofolate in the reaction catalyzed by N10-formyltetrahydrofolate synthetase.	Oxygen	8-14	nuclear receptor subfamily 4 group A member 1	Homo sapiens	96-99
8408001-1	1993	Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2.	Oxygen	172-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
8405432-4	1993	If this were the case, oxygen from solvent H2O would be incorporated into the formyl group of the N10-derivative.	Oxygen	23-29	nuclear receptor subfamily 4 group A member 1	Homo sapiens	98-101
8408001-1	1993	Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2.	Oxygen	172-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
8408001-8	1993	HIF-1 DNA binding activity decayed rapidly when hypoxic cells were exposed to increased oxygen tension.	Oxygen	88-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
8408001-10	1993	These findings are consistent with the proposed function of HIF-1 as a physiologic regulator of gene expression that responds to changes in cellular oxygen tension.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-65
8117514-10	1993	Factors that may contribute to the reduction in VA by ACE inhibitors include: increase in serum potassium; unloading of the ventricle; decrease in myocardial oxygen consumption.	Oxygen	158-164	angiotensin I converting enzyme	Homo sapiens	54-57
8397259-15	1993	These findings suggest that IL-6 down-modulates cytokine activation of M phi antileishmanial capacity by inhibiting oxygen-dependent and undefined oxygen-independent mechanisms.	Oxygen	116-122	interleukin 6	Homo sapiens	28-32
8262085-8	1993	Myocardial oxygen consumption following beta-blockade decreased both during spontaneous rhythm (25 +/- 15 to 16 +/- 8.8 ml min-1; P = 0.006), and during atrial pacing stress (30 +/- 13 to 23 +/- 11 ml.min-1; P = 0.004).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	123-128
8262085-8	1993	Myocardial oxygen consumption following beta-blockade decreased both during spontaneous rhythm (25 +/- 15 to 16 +/- 8.8 ml min-1; P = 0.006), and during atrial pacing stress (30 +/- 13 to 23 +/- 11 ml.min-1; P = 0.004).	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	201-206
7903278-3	1993	As studies with adherent neutrophils indicated that TNF might act as activating leucocyte integrins to deliver signals involved in activation of cell functions, we investigated the effects of monoclonal antibodies (mAb) directed against VLA-4 (CD49d/CD29), LFA-1 (CD11a/CD18), CR3 (CD11b/CD18) or the common beta 2 subunit (CD18) on generation of eosinophil toxic oxygen molecules and spreading.	Oxygen	364-370	tumor necrosis factor	Homo sapiens	52-55
8117975-1	1993	The noninvasive method for estimating the affinity of hemoglobin for oxygen (expressed as P50, oxygen tension at 50% hemoglobin saturation) allowed the authors to follow its time variations.	Oxygen	69-75	nuclear factor kappa B subunit 1	Homo sapiens	90-93
8276645-6	1993	The effect of oxygen supply on erythropoietin gene expression was confirmed by competitive polymerase chain reaction of erythropoietin mRNA and by radioimmunoassay of secreted erythropoietin.	Oxygen	14-20	erythropoietin	Homo sapiens	31-45
8276645-6	1993	The effect of oxygen supply on erythropoietin gene expression was confirmed by competitive polymerase chain reaction of erythropoietin mRNA and by radioimmunoassay of secreted erythropoietin.	Oxygen	14-20	erythropoietin	Homo sapiens	120-134
8276645-6	1993	The effect of oxygen supply on erythropoietin gene expression was confirmed by competitive polymerase chain reaction of erythropoietin mRNA and by radioimmunoassay of secreted erythropoietin.	Oxygen	14-20	erythropoietin	Homo sapiens	120-134
8397259-15	1993	These findings suggest that IL-6 down-modulates cytokine activation of M phi antileishmanial capacity by inhibiting oxygen-dependent and undefined oxygen-independent mechanisms.	Oxygen	147-153	interleukin 6	Homo sapiens	28-32
8521375-2	1993	An increase of hexokinase and lactate dehydrogenase activities with tumor volume, coupled with the decline of oxygen consumption are shown in this work.	Oxygen	110-116	hexokinase 1	Homo sapiens	15-25
8302290-1	1993	Catalase plays a major role in the protection of tissues from toxic effects of H2O2 and partially reduced oxygen species.	Oxygen	106-112	catalase	Capra hircus	0-8
7689565-5	1993	The increased sensitivity of the LFN7C/B3 cells to bleomycin and paraquat was also attributed to the ability of catalase in cells to prevent the drug-induced consumption of O2; by capturing H2O2 before it can escape the cell and converting it to O2, catalase can maintain the concentration of O2 either for repeated rounds of chemical reduction or for direct interaction with the toxin.	Oxygen	173-175	catalase	Homo sapiens	112-120
7689565-5	1993	The increased sensitivity of the LFN7C/B3 cells to bleomycin and paraquat was also attributed to the ability of catalase in cells to prevent the drug-induced consumption of O2; by capturing H2O2 before it can escape the cell and converting it to O2, catalase can maintain the concentration of O2 either for repeated rounds of chemical reduction or for direct interaction with the toxin.	Oxygen	192-194	catalase	Homo sapiens	112-120
7689565-5	1993	The increased sensitivity of the LFN7C/B3 cells to bleomycin and paraquat was also attributed to the ability of catalase in cells to prevent the drug-induced consumption of O2; by capturing H2O2 before it can escape the cell and converting it to O2, catalase can maintain the concentration of O2 either for repeated rounds of chemical reduction or for direct interaction with the toxin.	Oxygen	192-194	catalase	Homo sapiens	112-120
8401450-2	1993	An IBM-compatible minicomputer was programmed to direct the reaction of molecular [15O]oxygen with tri-(n-butyl)borane bound to alumina, followed by purification of product [15O]butanol via solid phase extraction with C18 Sep-Paks and sterile filtration.	Oxygen	87-93	Bardet-Biedl syndrome 9	Homo sapiens	218-221
8398494-6	1993	RESULTS: Maximal mean (SD) oxygen consumption on bicycle ergometry was 16.0 (4.5) ml min-1 kg-1.	Oxygen	27-33	CD59 molecule (CD59 blood group)	Homo sapiens	85-95
8398533-4	1993	Using a flow of oxygen 6 litre min-1 17% of Fluotec 3.8% of Isotec 3 and 71% of Enfluratec 3 vaporizers had outputs outside those limits.	Oxygen	16-22	CD59 molecule (CD59 blood group)	Homo sapiens	31-36
8396001-8	1993	LTB4, IL-8, and PLA2 levels were elevated in patients with NIP; LTB4 and PLA2 levels correlated with absolute neutrophil count, and IL-8 correlated with alveolar-arterial oxygen pressure difference.	Oxygen	171-177	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8396002-9	1993	We conclude that rSOD can be delivered by aerosol to the ELF of a large animal with preservation of specific activity and that a substantial increase in both the amount of SOD and the anti-O2.- capacity can be achieved for a period of time applicable to human therapy, supporting the rationale for evaluation of rSOD aerosol as an antioxidant in human pulmonary disease.	Oxygen	189-191	superoxide dismutase 1	Homo sapiens	18-21
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Oxygen	367-373	tumor necrosis factor	Homo sapiens	13-22
8403808-13	1993	Cu/Zn superoxide dismutase can catalyse the dismutation of O2 into H2O2 and generate OH..	Oxygen	59-61	superoxide dismutase 1	Homo sapiens	0-26
8142598-1	1993	The cytokine cachectin/TNF induces a rapid increase in lactate production and in glucose metabolism in L6 myocytes in culture; glucose uptake was maximal after 17 h, while elevated glucose utilization and lactate production persisted for up to 32 h. These increases are suggestive of increased glycolytic activity, and were associated with a 10% decrease in cellular oxygen consumption and a comparable decrease in the production of 14C-labelled CO2 from 14C-labelled glucose.	Oxygen	367-373	tumor necrosis factor	Homo sapiens	23-26
8397229-3	1993	When EPO producing Hep3B cells were incubated in 1% O2 for 30 min, cGMP levels in the Hep3B cells were significantly elevated, compared with cells incubated in 20% O2.	Oxygen	52-54	erythropoietin	Homo sapiens	5-8
8275990-9	1993	Catalase and deferoxamine, scavengers of active oxygen species, provided protection against smoke-induced mesothelial cell injury, but inactivated catalase did not.	Oxygen	48-54	catalase	Rattus norvegicus	0-8
8226515-4	1993	Fiber bundles from rat diaphragm were incubated with exogenous catalase (an antioxidant enzyme that dehydrates hydrogen peroxide to molecular oxygen and water) to decrease the tissue concentration of reactive oxygen intermediates.	Oxygen	142-148	catalase	Rattus norvegicus	63-71
8226515-4	1993	Fiber bundles from rat diaphragm were incubated with exogenous catalase (an antioxidant enzyme that dehydrates hydrogen peroxide to molecular oxygen and water) to decrease the tissue concentration of reactive oxygen intermediates.	Oxygen	209-215	catalase	Rattus norvegicus	63-71
8397229-3	1993	When EPO producing Hep3B cells were incubated in 1% O2 for 30 min, cGMP levels in the Hep3B cells were significantly elevated, compared with cells incubated in 20% O2.	Oxygen	164-166	erythropoietin	Homo sapiens	5-8
8353285-0	1993	Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.	Oxygen	9-15	nuclear factor kappa B subunit 1	Homo sapiens	39-49
8393874-1	1993	Cytochrome c oxidase contains a copper center, CuA, which is involved in electron transfer from cytochrome c to the oxygen-reducing active site.	Oxygen	116-122	cytochrome c, somatic	Homo sapiens	0-12
8393874-1	1993	Cytochrome c oxidase contains a copper center, CuA, which is involved in electron transfer from cytochrome c to the oxygen-reducing active site.	Oxygen	116-122	cytochrome c, somatic	Homo sapiens	96-108
8375690-1	1993	Catalase was continuously inhibited with aminotriazole in the liver and kidney during 33 months in large populations of old and young frogs in order to study the effects of the modification of the tissue antioxidant/prooxidant balance on the life span of a vertebrate species showing an oxygen consumption rate similar to that of humans.	Oxygen	287-293	catalase	Homo sapiens	0-8
8394777-1	1993	The activity of catalase, a key enzyme in cell detoxication of oxygen derivatives, was studied in SV40 transformed human fibroblasts.	Oxygen	63-69	catalase	Homo sapiens	16-24
8393637-13	1993	Despite the observed whole-body hemoconcentration, oxygen saturation was significantly higher during ANP infusion than during placebo infusion (84.7 +/- 1.7 versus 79.6 +/- 1.8%, p &lt; 0.05), and the alveolar-arterial oxygen difference was significantly lower (3.5 +/- 0.7 versus 7.3 +/- 0.8 mm Hg, p &lt; 0.01).	Oxygen	51-57	natriuretic peptide A	Homo sapiens	101-104
8393637-13	1993	Despite the observed whole-body hemoconcentration, oxygen saturation was significantly higher during ANP infusion than during placebo infusion (84.7 +/- 1.7 versus 79.6 +/- 1.8%, p &lt; 0.05), and the alveolar-arterial oxygen difference was significantly lower (3.5 +/- 0.7 versus 7.3 +/- 0.8 mm Hg, p &lt; 0.01).	Oxygen	219-225	natriuretic peptide A	Homo sapiens	101-104
8102956-2	1993	The mean and maximum life-spans of both wild type Caenorhabditis elegans and the mev-1(kn1) mutant, whose cytoplasmic superoxide dismutase activity level is about half of the wild type, were increased and decreased under low and high concentrations of oxygen, respectively.	Oxygen	252-258	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	81-86
7687217-3	1993	The maintenance of O2- production in response to N-formylmethionyl-leucyl-phenyl-alanine (FMLP) suggested that these neutrophils were functionally alive.	Oxygen	19-21	formyl peptide receptor 1	Homo sapiens	90-94
8226450-7	1993	Administration of supplementary oxygen significantly decreased ACTH to baseline values (P &lt; 0.01) together with a decrease in aldosterone.	Oxygen	32-38	proopiomelanocortin	Homo sapiens	63-67
8397132-4	1993	When compared to the controls, the patients with cirrhosis had significantly lower production of O2- upon stimulation by N-formyl-Met-Leu-Phe (fMLP) or opsonic zymosan (OZ).	Oxygen	97-99	formyl peptide receptor 1	Homo sapiens	143-147
7691771-1	1993	Recombinant human erythropoietin (EPO), commercially available since 1988, is thought to be used by athletes in aerobic sports for the purpose of increasing oxygen transport and aerobic power.	Oxygen	157-163	erythropoietin	Homo sapiens	18-32
7691771-1	1993	Recombinant human erythropoietin (EPO), commercially available since 1988, is thought to be used by athletes in aerobic sports for the purpose of increasing oxygen transport and aerobic power.	Oxygen	157-163	erythropoietin	Homo sapiens	34-37
8340389-9	1993	Only stimulated cells produced measurable amounts of O2(1 delta g) in a dose-dependent response to either PMA or fMLP.	Oxygen	53-55	formyl peptide receptor 1	Homo sapiens	113-117
7687633-1	1993	"Classical" chemoattractants, such as FMLP, C5a, or leukotriene B4, not only elicit directed motility but also activate neutrophils (degranulation, release of active oxygen species).	Oxygen	166-172	formyl peptide receptor 1	Homo sapiens	38-42
7687633-1	1993	"Classical" chemoattractants, such as FMLP, C5a, or leukotriene B4, not only elicit directed motility but also activate neutrophils (degranulation, release of active oxygen species).	Oxygen	166-172	complement C5a receptor 1	Homo sapiens	44-47
8408873-5	1993	Our results have shown that the somatolactogens and a member of the somatomedin family, IGF-I, are particularly effective in modulating the effector functions in phagocytic cells, including the production of reactive oxygen intermediates and tumor necrosis factor-alpha and the oxygen-dependent killing of bacteria.	Oxygen	217-223	insulin like growth factor 1	Homo sapiens	88-93
8335936-8	1993	The elevated antilisterial activity of IFN-gamma-treated hepatocytes in culture was abrogated by the presence of compounds that scavenged or inhibited the production of reactive oxygen intermediates.	Oxygen	178-184	interferon gamma	Mus musculus	39-48
8335936-9	1993	Taken together, these findings suggest that activation of the oxygen-dependent, antimicrobial activity of hepatocytes may constitute a principal effector function of IFN-gamma in host defenses to listerial infections of the liver.	Oxygen	62-68	interferon gamma	Mus musculus	166-175
8371659-4	1993	Results indicated the standard error of estimate for the predicted oxygen consumption values ranged from 80-156 ml.min-1, with correlations between the actual and predicted values ranging from r = 0.35 to r = 0.67.	Oxygen	67-73	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
8340389-11	1993	The maximal response for fMLP was at a concentration of 1 microM, 18.4 +/- 1.0 nmol of O2(1 delta g)/approximately 1.00 x 10(6) cells.	Oxygen	87-89	formyl peptide receptor 1	Homo sapiens	25-29
8375460-10	1993	Treatment of renal anaemia by erythropoietin thus results in improved tissue oxygen supply during exercise, reflected by delay in the onset of lactic acidaemia.	Oxygen	77-83	erythropoietin	Homo sapiens	30-44
8314769-5	1993	The two genes are regulated reciprocally by oxygen, where under aerobic conditions TIF51A is expressed and TIF51B is repressed, and under anaerobic conditions the opposite occurs.	Oxygen	44-50	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	107-113
8304819-2	1993	Angiotensin Converting Enzyme (ACE) inhibitors, by their indirect effects (improved conditions of left ventricular load, negative inotropism, attenuation of catecholaminergic stimulation), reduce myocardial oxygen consumption, and by their direct coronary vasodilator effect reduce myocardial ischaemia.	Oxygen	207-213	angiotensin I converting enzyme	Homo sapiens	0-29
8304819-2	1993	Angiotensin Converting Enzyme (ACE) inhibitors, by their indirect effects (improved conditions of left ventricular load, negative inotropism, attenuation of catecholaminergic stimulation), reduce myocardial oxygen consumption, and by their direct coronary vasodilator effect reduce myocardial ischaemia.	Oxygen	207-213	angiotensin I converting enzyme	Homo sapiens	31-34
8396523-10	1993	The oxygen uptake in resting skeletal muscles was 6.9 +/- 0.3 mumol 100 g-1 min-1 before chemotherapy and 7.0 +/- 0.7 mumol 100 g-1 min-1 after chemotherapy.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
8396523-10	1993	The oxygen uptake in resting skeletal muscles was 6.9 +/- 0.3 mumol 100 g-1 min-1 before chemotherapy and 7.0 +/- 0.7 mumol 100 g-1 min-1 after chemotherapy.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	132-137
8342645-2	1993	To further understand the underlying mechanism(s), we investigated the O2 dependence of the endothelium-dependent relaxations elicited by ionophore A-23187 or agonists substance P (SP) or thrombin (TB) in porcine coronary arteries.	Oxygen	71-73	tachykinin precursor 1	Homo sapiens	168-179
8342645-6	1993	Hypoxic conditions (95% N2-5% CO2 instead of 95% O2-5% CO2; PO2 &lt; 1%) abolished the A-23187 rapid phase and the SP and TB transient relaxation but not the A-23187 slow phase.	Oxygen	31-33	tachykinin precursor 1	Homo sapiens	115-117
8342645-11	1993	Our results suggest that the rapid relaxations to A-23187, SP, and TB are sensitive to O2 but not mitochondrial respiration.	Oxygen	87-89	tachykinin precursor 1	Homo sapiens	59-61
8403591-3	1993	Erythropoietin is a glycoprotein growth factor synthesized by cells adjacent to the proximal renal tubule in response to signals from a renal oxygen-sensing device, probably a heme protein (1).	Oxygen	142-148	erythropoietin	Homo sapiens	0-14
8326022-5	1993	Whereas low oxygen tension (PO2 = 20-30 Torr) increases ET-1 expression four- to eightfold above that seen at normal oxygen tension (PO2 = 150 Torr), sodium nitroprusside, which releases NO, suppresses this effect.	Oxygen	12-18	endothelin 1	Homo sapiens	56-60
21573333-4	1993	These results suggest that MDR in CEM/VLB100 is a complicated phenotype which not only involves a PGP mechanism, but also a SOD protection mechanism against drug-mediated O2.- cytotoxicity.	Oxygen	171-173	ATP binding cassette subfamily B member 1	Homo sapiens	98-101
8407882-7	1993	The oxygen consumption activity of cytochrome aco3 was measured using several kinds of cytochromes c as the electron mediators.	Oxygen	4-10	iron responsive element binding protein 2	Homo sapiens	46-50
8317683-15	1993	The grand mean oxygen uptake rate was 2.5 ml.kg-1 x min-1 or 100 ml.min-1 x m-2.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
8516341-4	1993	Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity.	Oxygen	164-170	tumor necrosis factor	Homo sapiens	93-132
8333930-2	1993	On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and materno-fetal interrelations, and diagnose raised EPO levels as markers of oxygen deficiency.	Oxygen	302-308	erythropoietin	Homo sapiens	127-130
8375018-7	1993	Using a mitomycin C resistant human cell strain (3437T) from a cancer prone family, a possible role for DT-diaphorase, an oxygen insensitive 2-electron transfer enzyme, is suggested.	Oxygen	122-128	NAD(P)H quinone dehydrogenase 1	Homo sapiens	104-117
8337015-4	1993	The arteriolar/alveolar oxygen-tension ratio showed an inverse correlation with the logarithm (In) of the ANF concentration (r = -0.55, P = 0.0002).	Oxygen	24-30	natriuretic peptide A	Homo sapiens	106-109
8337015-5	1993	Both mean airway pressure and In ANF showed an inverse correlation with the arteriolar/alveolar oxygen tension ratio (R = -0.77, F = 20.5 and 13.8, respectively).	Oxygen	96-102	natriuretic peptide A	Homo sapiens	33-36
8391810-0	1993	The potentiation by TNF-alpha and PMA of Fc receptor-mediated phagocytosis in neutrophils is independent of reactive oxygen metabolites produced by NADPH oxidase and of protein kinase C. The results presented in this paper demonstrate that the potentiation of phagocytosis of erythrocyte (E) IgG by TNF-alpha or PMA is not due to an oxygen-dependent mechanism.	Oxygen	333-339	tumor necrosis factor	Homo sapiens	20-29
8395934-0	1993	Formation of a hydroxyl radical by the myeloperoxidase-NADH-oxygen system.	Oxygen	60-66	myeloperoxidase	Homo sapiens	39-54
8395934-6	1993	Even though the superoxide radical (O2-)-producing ability of the MPO-NADH system was about 29% of that of the hypoxanthine-xanthine oxidase system, under the experimental conditions employed, the rate of tyrosine formation from phenylalanine by two systems was found to be a similar.	Oxygen	36-38	myeloperoxidase	Homo sapiens	66-69
8375015-1	1993	NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes.	Oxygen	275-281	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-31
8375015-1	1993	NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes.	Oxygen	275-281	NAD(P)H quinone dehydrogenase 1	Homo sapiens	33-37
8375015-1	1993	NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes.	Oxygen	275-281	NAD(P)H quinone dehydrogenase 1	Homo sapiens	53-66
8498572-4	1993	Platelet response to FMLP-activated PMN was enhanced by superoxide dismutase and blocked by catalase or the NADPH oxidase inhibitor diphenyliodonium, suggesting a role for the O2-.-H2O2 system in this cellular interaction.	Oxygen	176-178	formyl peptide receptor 1	Homo sapiens	21-25
8317683-15	1993	The grand mean oxygen uptake rate was 2.5 ml.kg-1 x min-1 or 100 ml.min-1 x m-2.	Oxygen	15-21	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
8317683-17	1993	The mean oxygen uptake rate at 10 min was between 2.0 and 2.2 ml.kg-1 x min-1 in all groups.	Oxygen	9-15	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
8358330-2	1993	In platelets isolated from diabetes, the oxygen consumption which reflects mainly the degree of fatty acid oxidation and ADP- and thrombin-induced aggregation were increased as compared to non-diabetic rat platelets.	Oxygen	41-47	coagulation factor II	Rattus norvegicus	130-138
8317683-18	1993	At 30 min the mean oxygen uptake rates were 2.6 to 2.8 ml.kg-1 x min-1.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	65-70
8218938-3	1993	However, production of active oxygen molecules was suppressed by TGF-beta 1.	Oxygen	30-36	transforming growth factor beta 1	Homo sapiens	65-75
8218938-4	1993	On the other hand, IL-6 stimulated production of active oxygen molecules and ADCC of the cells treated with VD3 and tumor necrosis factor-alpha (TNF-alpha).	Oxygen	56-62	interleukin 6	Homo sapiens	19-23
8218938-4	1993	On the other hand, IL-6 stimulated production of active oxygen molecules and ADCC of the cells treated with VD3 and tumor necrosis factor-alpha (TNF-alpha).	Oxygen	56-62	tumor necrosis factor	Homo sapiens	116-143
8218938-4	1993	On the other hand, IL-6 stimulated production of active oxygen molecules and ADCC of the cells treated with VD3 and tumor necrosis factor-alpha (TNF-alpha).	Oxygen	56-62	tumor necrosis factor	Homo sapiens	145-154
8491496-3	1993	Local hyperinsulinemia in the forearm (132 +/- 25 microunits/mL for 90 minutes) induced a significant increase in the utilization of glucose from baseline (16.4 +/- 3.1 mg.dL-1.min-1 per 100 mL forearm volume) to a plateau (85.7 +/- 15.1 mg.dL-1.min-1 per 100 mL forearm volume) between 40 and 60 minutes of insulin infusion but did not alter the utilization of oxygen.	Oxygen	362-368	insulin	Homo sapiens	11-18
8349141-1	1993	[Met]-enkephalin or its precursor, pre-[Met]-enkephalin, were exposed to activated oxygen species produced by human phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs) and then analyzed by high-pressure liquid chromatography (HPLC).	Oxygen	83-89	proopiomelanocortin	Homo sapiens	1-16
8349141-1	1993	[Met]-enkephalin or its precursor, pre-[Met]-enkephalin, were exposed to activated oxygen species produced by human phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs) and then analyzed by high-pressure liquid chromatography (HPLC).	Oxygen	83-89	proopiomelanocortin	Homo sapiens	40-55
8390370-5	1993	HIV-1 infected or transfected Hep3B cells produced Epo at significantly lower levels than uninfected Hep3B cells under low O2 conditions or following exposure to cobalt chloride.	Oxygen	123-125	erythropoietin	Homo sapiens	51-54
8099103-1	1993	The time-courses of absorption changes after pulse radiolysis of oxygen-saturated solution of lactoperoxidase have been studied.	Oxygen	65-71	lactoperoxidase	Homo sapiens	94-109
8384878-1	1993	It has recently been demonstrated that strong illumination under anaerobic conditions leads to the double reduction of the primary quinone acceptor, QA, which in turn promotes the light-induced formation of triplet reaction center chlorophyll, 3P680, a potentially dangerous species to its protein surroundings in the presence of oxygen [Vass, I., Styring, S., Hundal, T., Koivuniemi, A., Aro, E.-M., &amp; Anderson, B.	Oxygen	330-336	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	389-392
8510671-4	1993	The burst of NADH oxidation and oxygen uptake which occurs in phosphate, but not in Tris buffer, was prevented by SOD, catalase, histidine, EDTA, MnCl2 and CuSO4, but not by the hydroxyl radical quenchers, ethanol, methanol, formate and mannitol.	Oxygen	32-38	catalase	Rattus norvegicus	119-127
8476066-10	1993	Exposure to hyperoxia (95% O2) delayed the entry of released cells into the S phase of the cell cycle and blocked the cells in the S or G2 phase, but induced Cu,Zn SOD mRNA before the S phase and caused persistence of elevation of Cu,Zn SOD mRNA as cells progressed through their cycles.	Oxygen	27-29	superoxide dismutase 1	Homo sapiens	164-167
8482049-7	1993	After 6 +/- 3 months on recombinant human erythropoietin, maximal exercise capacity increased from 108 +/- 27 W to 130 +/- 36W (P &lt; 0.001) and the maximal oxygen uptake increased from 1.24 +/- 0.39 litres/min to 1.50 +/- 0.45 litres/min (P &lt; 0.001).	Oxygen	158-164	erythropoietin	Homo sapiens	42-56
8372242-0	1993	New modality of radiation therapy under increased tumor oxygen tension with angiotensin II: a pilot study.	Oxygen	56-62	angiotensinogen	Homo sapiens	76-90
8098618-11	1993	Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.	Oxygen	63-69	nuclear factor kappa B subunit 1	Homo sapiens	139-149
8098618-11	1993	Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.	Oxygen	63-69	interleukin 2	Homo sapiens	183-187
8389744-0	1993	The sequence of electron carriers in the reaction of cytochrome c oxidase with oxygen.	Oxygen	79-85	cytochrome c, somatic	Homo sapiens	53-65
8477727-7	1993	In addition, they show that the AAC3 gene belongs to the family of yeast genes including TIF51B, COX5b, HEM13 and CYC7 that are negatively regulated by oxygen and heme.	Oxygen	152-158	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	89-95
8477727-7	1993	In addition, they show that the AAC3 gene belongs to the family of yeast genes including TIF51B, COX5b, HEM13 and CYC7 that are negatively regulated by oxygen and heme.	Oxygen	152-158	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	97-102
8098954-5	1993	This inactivation was prevented by catalase, which suggests that the NAD(P)H/BV2+/O2-dependent system has a role in H2O2 production.	Oxygen	82-84	catalase	Rattus norvegicus	35-43
8389744-2	1993	Transient-state studies of the reaction with oxygen have led to the proposal of a sequence of carriers from cytochrome c, to CuA, to cytochrome a, and then to the binuclear (i.e., cytochrome a3-CuB) center.	Oxygen	45-51	cytochrome c, somatic	Homo sapiens	108-120
8389746-1	1993	Cytochrome c oxidase oxidizes cytochrome c and reduces molecular oxygen to water.	Oxygen	65-71	cytochrome c, somatic	Homo sapiens	0-12
24318796-0	1993	The role of CP 47 in the evolution of oxygen and the binding of the extrinsic 33-kDa protein to the core complex of Photosystem II as determined by limited proteolysis.	Oxygen	38-44	beaded filament structural protein 2	Homo sapiens	12-17
8386241-4	1993	Covalent binding required oxygen and NADPH, and was decreased by the nucleophile glutathione and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily).	Oxygen	26-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	104-120
8386241-4	1993	Covalent binding required oxygen and NADPH, and was decreased by the nucleophile glutathione and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily).	Oxygen	26-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	202-218
8315800-6	1993	In order to maintain the inspired oxygen concentration at 35%, the flow of nitrous oxide should have been reduced as low as to 150 ml.min-1 after 240 min.	Oxygen	34-40	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
8103922-7	1993	3) Isoprenaline have different effects on generation of reactive oxygen intermediates and cell aggregation in FMLP-activated granulocytes.	Oxygen	65-71	formyl peptide receptor 1	Homo sapiens	110-114
24318796-5	1993	The oxygen-evolving activity and the capacity for rebinding of the 33-kDa protein to the core complex of Photosystem II decreased in parallel, with kinetics very similar to those of the cleavage of CP 47 at Lys389.	Oxygen	4-10	beaded filament structural protein 2	Homo sapiens	198-203
8350498-5	1993	Because anemia reduces renal oxygen availability, anemic stress accelerates EPO production in the kidney.	Oxygen	29-35	erythropoietin	Homo sapiens	76-79
8350498-4	1993	The rate of production of EPO is regulated primarily by renal oxygen availability.	Oxygen	62-68	erythropoietin	Homo sapiens	26-29
24318796-6	1993	These observations strongly suggest that the hydrophilic domain around Lys389 of CP 47, which are located on the lumenal side, is important in the binding of the 33-kDa protein and in maintaining the oxygen-evolving activity of the Photosystem II complex.	Oxygen	200-206	beaded filament structural protein 2	Homo sapiens	81-86
8480339-10	1993	From these findings we conclude that the potentiation of CCl4 liver injury by VA pretreatment is mediated, at least in part, by active oxygen species released from Kupffer cells and possibly other macrophages that are activated by VA.	Oxygen	135-141	C-C motif chemokine ligand 4	Rattus norvegicus	57-61
8461317-2	1993	This property together with new molecular biology evidence that oxidants such as H2O2 can induce gene transcription of DT-diaphorase provide especially intriguing reasons to examine the possibility that lung DT-diaphorase could have an important antioxidant enzyme role versus pulmonary O2 toxicity during exposure to hyperoxia.	Oxygen	83-85	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	119-132
8461317-2	1993	This property together with new molecular biology evidence that oxidants such as H2O2 can induce gene transcription of DT-diaphorase provide especially intriguing reasons to examine the possibility that lung DT-diaphorase could have an important antioxidant enzyme role versus pulmonary O2 toxicity during exposure to hyperoxia.	Oxygen	83-85	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	208-221
8460154-0	1993	Inducible operation of the erythropoietin 3" enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.	Oxygen	104-110	erythropoietin	Homo sapiens	27-41
8460154-2	1993	A well-characterized example is the hypoxic induction of the synthesis of erythropoietin, a hormone which regulates erythropoiesis and hence blood oxygen content.	Oxygen	147-153	erythropoietin	Homo sapiens	74-88
8460154-3	1993	The restricted expression of the erythropoietin gene in subsets of cells within kidney and liver has suggested that this specific oxygen-sensing mechanism is restricted to specialized cells in those organs.	Oxygen	130-136	erythropoietin	Homo sapiens	33-47
8460154-4	1993	Using transient transfection of reporter genes coupled to a transcriptional enhancer lying 3" to the erythropoietin gene, we show that an oxygen-sensing system similar, or identical, to that controlling erythropoietin expression is wide-spread in mammalian cells.	Oxygen	138-144	erythropoietin	Homo sapiens	101-115
8460154-4	1993	Using transient transfection of reporter genes coupled to a transcriptional enhancer lying 3" to the erythropoietin gene, we show that an oxygen-sensing system similar, or identical, to that controlling erythropoietin expression is wide-spread in mammalian cells.	Oxygen	138-144	erythropoietin	Homo sapiens	203-217
8482686-1	1993	Superoxide dismutase (SOD) has an important role in the protection against O2 toxicity.	Oxygen	75-77	superoxide dismutase 1	Rattus norvegicus	22-25
8384954-2	1993	To clarify the relationship between nocturnal oxygen desaturation and erythropoietin production in patients with chronic obstructive pulmonary disease, we determined arterial oxygen saturation and serum immunoreactive erythropoietin levels over 24 h in eight patients with chronic obstructive pulmonary disease and in nine normal subjects.	Oxygen	46-52	erythropoietin	Homo sapiens	70-84
8446170-6	1993	Here we report tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O2.- to O2 and H2O2 (ref.	Oxygen	219-221	superoxide dismutase 1	Homo sapiens	123-127
8446170-6	1993	Here we report tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O2.- to O2 and H2O2 (ref.	Oxygen	227-229	superoxide dismutase 1	Homo sapiens	123-127
8460711-6	1993	Although fMLP treatment caused 247 +/- 28% increase from baseline level in O2-.	Oxygen	75-77	formyl peptide receptor 1	Homo sapiens	9-13
8467759-10	1993	It is concluded that daily intratracheal administration of PEG-CAT 4000 U + CuZn SOD 300 U can significantly ameliorate some of the chronic parenchymal and vascular lung O2 toxic changes.	Oxygen	170-172	superoxide dismutase 1	Rattus norvegicus	76-84
8482686-10	1993	We conclude that insufflation of PEG-SOD protects rats against O2 toxicity, possibly by enhancing pulmonary SOD activity.	Oxygen	63-65	superoxide dismutase 1	Rattus norvegicus	37-40
8381307-8	1993	When Hep3B cells were incubated in the presence of decreasing O2 tension from 160 to 7 mm Hg, there was a monotonic increase in Epo mRNA to 50 to 100 times the normoxic level.	Oxygen	62-64	erythropoietin	Homo sapiens	128-131
8441566-6	1993	Measurement of oxygen saturation, pH, and PaO2 provided the information for plotting the oxygen dissociation curve, the P50 and P90.	Oxygen	15-21	nuclear factor kappa B subunit 1	Homo sapiens	120-123
8382025-10	1993	Under CWF light, catalase inhibited and superoxide dismutase (SOD) stimulated formation of DNA SSB, indicating H2O2 was generated from O2-.	Oxygen	113-115	catalase	Homo sapiens	17-25
8382025-10	1993	Under CWF light, catalase inhibited and superoxide dismutase (SOD) stimulated formation of DNA SSB, indicating H2O2 was generated from O2-.	Oxygen	113-115	superoxide dismutase 1	Homo sapiens	40-60
8382025-10	1993	Under CWF light, catalase inhibited and superoxide dismutase (SOD) stimulated formation of DNA SSB, indicating H2O2 was generated from O2-.	Oxygen	113-115	superoxide dismutase 1	Homo sapiens	62-65
8464599-1	1993	For many people who deal with medical emergencies--some human resource managers, emergency team administrators, CPR and first aid instructors, EMTs, nurses and physicians--the topic of oxygen use by nonmedical responders at the workplace is poorly understood.	Oxygen	185-191	cytochrome p450 oxidoreductase	Homo sapiens	112-115
8094958-1	1993	In these studies we show that stimulation of O2- generation by Tumor necrosis factor-alpha (TNF), or antibodies against the common beta 2 chain of leukocyte integrins (CD18), or LFA-1 (CD11a) displays a common and unique pattern of sensitivity or insensitivity to inhibitors of different signalling pathways.	Oxygen	45-47	tumor necrosis factor	Homo sapiens	63-90
8094958-1	1993	In these studies we show that stimulation of O2- generation by Tumor necrosis factor-alpha (TNF), or antibodies against the common beta 2 chain of leukocyte integrins (CD18), or LFA-1 (CD11a) displays a common and unique pattern of sensitivity or insensitivity to inhibitors of different signalling pathways.	Oxygen	45-47	tumor necrosis factor	Homo sapiens	92-95
8448809-3	1993	The reaction was inhibited by O2, CO, miconazole, dihydroergotamine and troleandomycin showing that it was catalyzed by cytochrome P-450 CYP3A isoforms.	Oxygen	30-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	120-136
8435086-11	1993	These results rule out a major role for PKC-delta (not activated by SAPA) and PKC-beta 1 (activated by DOPPA), but suggest the involvement of RX kinase in addition to PKC in the inhibition of fMLP-stimulated Mn2+ influx and potentiation of fMLP-stimulated O2-.	Oxygen	256-258	formyl peptide receptor 1	Homo sapiens	192-196
8435086-17	1993	Finally, use of fura-2 and SK&amp;F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	Oxygen	186-188	formyl peptide receptor 1	Homo sapiens	60-64
8435086-17	1993	Finally, use of fura-2 and SK&amp;F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	Oxygen	186-188	formyl peptide receptor 1	Homo sapiens	109-113
8357335-3	1993	Antiischemic effects of ACE-inhibitors may be exerted through a reduction of myocardial oxygen demand, by a reduction of angiotensin-mediated coronary vasoconstriction, by an interaction with bradykinin and the prostaglandin system, by a modulation of endothelial control of vascular tone, and by an interaction with the sympathetic nervous system.	Oxygen	88-94	angiotensin I converting enzyme	Homo sapiens	24-27
8429783-4	1993	During perfusion with medium equilibrated with 95%/5% O2/CO2, changes in PFC T1s indicate that the average oxygen concentration was reduced from 894 +/- 102 microM in the absence of cells to 476 +/- 65 microM and 475 +/- 50 microM in the presence of 0.7 x 10(8) EMT6/Ro and RIF-1 murine tumor cells per milliliter of gel, respectively.	Oxygen	107-113	replication timing regulatory factor 1	Mus musculus	274-279
8385264-3	1993	We investigated the oxygen-dependent bactericidal activities including the ability to generate O2-, Myeloperoxidase (MPO) activity and opsonic activity using chemiluminescence method.	Oxygen	20-26	myeloperoxidase	Homo sapiens	100-115
8385264-3	1993	We investigated the oxygen-dependent bactericidal activities including the ability to generate O2-, Myeloperoxidase (MPO) activity and opsonic activity using chemiluminescence method.	Oxygen	20-26	myeloperoxidase	Homo sapiens	117-120
8424172-2	1993	Addition of inorganic nutrients, biphenyl, and oxygen enhanced PCB biodegradation, as indicated both by a 37 to 55 percent loss of PCBs and by the production of chlorobenzoates, intermediates in the PCB biodegradation pathway.	Oxygen	47-53	pyruvate carboxylase	Homo sapiens	63-66
8424172-2	1993	Addition of inorganic nutrients, biphenyl, and oxygen enhanced PCB biodegradation, as indicated both by a 37 to 55 percent loss of PCBs and by the production of chlorobenzoates, intermediates in the PCB biodegradation pathway.	Oxygen	47-53	pyruvate carboxylase	Homo sapiens	131-134
8422907-4	1993	The LXA4 omega-hydroxylation requires both molecular oxygen and NADPH, and is inhibited by carbon monoxide, by antibodies raised against NADPH-cytochrome P-450 reductase, or competitively by leukotriene B4 (LTB4) and LTB5, substrates of LTB4 omega-hydroxylase.	Oxygen	53-59	cytochrome p450 oxidoreductase	Homo sapiens	137-169
8422907-4	1993	The LXA4 omega-hydroxylation requires both molecular oxygen and NADPH, and is inhibited by carbon monoxide, by antibodies raised against NADPH-cytochrome P-450 reductase, or competitively by leukotriene B4 (LTB4) and LTB5, substrates of LTB4 omega-hydroxylase.	Oxygen	53-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	237-259
8317338-10	1993	These data suggest dependent on toxic oxygen and L-arginine products of neutrophils, the accumulation of which can be linked to cytokines (TNF alpha, IL-1), beta 2 integrins and endothelial adhesion molecules.	Oxygen	38-44	tumor necrosis factor	Rattus norvegicus	139-148
7690656-0	1993	[Oxygen-dependent erythropoietin production--basic principle for compensation of blood loss].	Oxygen	1-7	erythropoietin	Homo sapiens	18-32
7679371-4	1993	The O2- production induced by substance P was also found to be fivefold higher in exudate cells, while the metabolic response to other stimulants such as concanavalin A (con A), phorbol-myristate acetate (PMA), NaF, and immunocomplexes was not primed.	Oxygen	4-6	tachykinin precursor 1	Homo sapiens	30-41
8432858-8	1993	O2 plus endotoxin increased the concentration and stability of MnSOD, catalase, and GP mRNAs.	Oxygen	0-2	catalase	Rattus norvegicus	70-78
8418841-9	1993	The oxygen binding affinities of most of the major modified hemoglobins have been measured and are characterized by P50 values from about 1/2 to over 5 times that of unmodified human hemoglobin.	Oxygen	4-10	nuclear factor kappa B subunit 1	Homo sapiens	116-119
8117850-0	1993	Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.	Oxygen	64-70	superoxide dismutase 1	Homo sapiens	24-44
8117850-0	1993	Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.	Oxygen	64-70	catalase	Homo sapiens	45-53
8117850-2	1993	We found that PolyHb-SOD-catalase is effective in scavenging oxygen-derived free radicals.	Oxygen	61-67	superoxide dismutase 1	Homo sapiens	21-24
8515670-0	1993	Evaluation of changes in oxygen tension as indicators of RIF-1 tumor response to Nd:YAG laser heating.	Oxygen	25-31	replication timing regulatory factor 1	Mus musculus	57-62
8117850-2	1993	We found that PolyHb-SOD-catalase is effective in scavenging oxygen-derived free radicals.	Oxygen	61-67	catalase	Homo sapiens	25-33
27314787-7	1993	The addition of H2O2 and catalase to the reaction system supplied molecular oxygen for methanol oxidation to formaldehyde by alcohol oxidase.	Oxygen	76-82	catalase	Homo sapiens	16-33
8402759-4	1993	PMN O2- production was measured by cytochrome c reduction.	Oxygen	4-6	cytochrome c, somatic	Homo sapiens	35-47
8513306-5	1993	Infusion of the subpressor dose of AngII decreased myocardial oxygen supply, both at rest and during exercise; the pressor dose increased myocardial oxygen supply at rest and blunted the expected increase in myocardial oxygen supply during exercise.	Oxygen	62-68	angiotensinogen	Homo sapiens	35-40
8513306-5	1993	Infusion of the subpressor dose of AngII decreased myocardial oxygen supply, both at rest and during exercise; the pressor dose increased myocardial oxygen supply at rest and blunted the expected increase in myocardial oxygen supply during exercise.	Oxygen	149-155	angiotensinogen	Homo sapiens	35-40
8513306-5	1993	Infusion of the subpressor dose of AngII decreased myocardial oxygen supply, both at rest and during exercise; the pressor dose increased myocardial oxygen supply at rest and blunted the expected increase in myocardial oxygen supply during exercise.	Oxygen	149-155	angiotensinogen	Homo sapiens	35-40
8314113-2	1993	The breaking in the presence of oxygen was not inhibited by superoxide dismutase and catalase, but inhibited by mannitol, ethanol, butyl hydroxyanisole, thiol compounds, tertiary amines and spin trapping agents N-tert-butyl-alpha-phenylnitrone (PBN) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	Oxygen	32-38	catalase	Homo sapiens	85-93
8167696-3	1993	We report here that MDM treated with IFN-gamma developed an increase in their capacity to ingest and kill unopsonized C. albicans and to release O2- upon stimulation with candida.	Oxygen	145-147	interferon gamma	Homo sapiens	37-46
8448446-2	1993	The sulfite in liquid foods or extracts of solid foods is analyzed according to the following principle: Sulfite ions are oxidized to sulfate ions by oxygen in the presence of sulfite oxidase, thereby forming hydrogen peroxide.	Oxygen	150-156	LOW QUALITY PROTEIN: sulfite oxidase	Malus domestica	176-191
8324093-8	1993	Cord serum Epo correlates better with oxygen tension and pH at birth than with fetal growth and haematocrit, which are measures of chronic stress to the fetus.	Oxygen	38-44	erythropoietin	Homo sapiens	11-14
8054580-0	1993	[Stimulation of oxygen metabolism in human blood phagocytes as affected by tuftsin-like peptides derived from the C-reactive protein molecule].	Oxygen	16-22	C-reactive protein	Homo sapiens	114-132
8054580-1	1993	Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied.	Oxygen	133-139	C-reactive protein	Homo sapiens	83-101
8054580-1	1993	Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied.	Oxygen	133-139	C-reactive protein	Homo sapiens	103-106
8054580-3	1993	CRP-derived peptides stimulated phagocyte oxygen metabolism as effectively as tuftsin.	Oxygen	42-48	C-reactive protein	Homo sapiens	0-3
8019919-4	1993	For instance, there is in vitro evidence that locally generated reactive oxygen metabolites: 1) cause increased release of TNF alpha into the extracellular space by accelerating the cleavage of its cell-associated precursor, and 2) reduce the expression of both cell-associated and soluble TNF alpha receptors.	Oxygen	73-79	tumor necrosis factor	Homo sapiens	123-132
8019919-4	1993	For instance, there is in vitro evidence that locally generated reactive oxygen metabolites: 1) cause increased release of TNF alpha into the extracellular space by accelerating the cleavage of its cell-associated precursor, and 2) reduce the expression of both cell-associated and soluble TNF alpha receptors.	Oxygen	73-79	tumor necrosis factor	Homo sapiens	290-299
8019919-5	1993	Thus it might be expected that reactive oxygen metabolites released at the site of glomerular inflammation limit autocrine, juxtacrine and paracrine effects of TNF alpha and simultaneously increase its widespread release into the circulation.	Oxygen	40-46	tumor necrosis factor	Homo sapiens	160-169
8472690-2	1993	Exercise of 6-min duration at a power output equivalent to 92 (SD 5)% maximal oxygen uptake (VO2max), whether performed at a pedalling frequency of 60 or 120 rev.min-1, reduced maximal STPO generated at 120 rev.min-1 to a much greater extent than maximal STPO at 60 rev.min-1.	Oxygen	78-84	CD59 molecule (CD59 blood group)	Homo sapiens	162-167
8375432-2	1993	Iron-dependent microsomal lipid peroxidation could be initiated by reduced irons coordinated with phosphate moieties in the membranes and significantly inhibited by copper salicylate (hydrophobic and permeable O2-scavenger) and desferrioxamine (a powerful iron-chelating agent), but not by SOD.	Oxygen	210-212	superoxide dismutase 1	Homo sapiens	290-293
8244086-5	1993	Chemiluminescence assays of oxidation of hypoxanthine by xanthine oxidase in the presence of luminol, confirm that the three ACE inhibitors are oxygen free radical scavengers.	Oxygen	144-150	angiotensin I converting enzyme	Homo sapiens	125-128
8094923-4	1993	Similarly, the production of reactive nitrogen and oxygen intermediates by MAM were significantly (P &lt; 0.05) lower compared with control macrophages (CAM).	Oxygen	51-57	activating transcription factor 7 interacting protein	Mus musculus	75-78
8394533-0	1993	Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal anaemia.	Oxygen	8-14	erythropoietin	Homo sapiens	81-95
8394533-0	1993	Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal anaemia.	Oxygen	48-54	erythropoietin	Homo sapiens	81-95
8394533-2	1993	In this study we have measured oxygen affinity as P50 and calculated the oxygen releasing capacity of blood from 10 haemodialysis patients treated with erythropoietin (rHuEpo).	Oxygen	31-37	nuclear factor kappa B subunit 1	Homo sapiens	50-53
8394533-4	1993	During the first phase of treatment the oxygen releasing capacity improved because of an increase in the haemoglobin concentration and P50.	Oxygen	40-46	nuclear factor kappa B subunit 1	Homo sapiens	135-138
8394533-5	1993	During the second phase there was a further significant increase in haemoglobin concentration, but due to a decrease in the P50 value the oxygen releasing capacity remained unchanged.	Oxygen	138-144	nuclear factor kappa B subunit 1	Homo sapiens	124-127
8450913-10	1993	Breathing 100% O2 resulted in a significant decrease in all enzyme activities (to 38.6% for catalase, 45% for SOD and to 27.4% for GPX).	Oxygen	15-17	catalase	Rattus norvegicus	92-100
8469893-4	1993	Macrophages/monocytes and polymorphonuclear leucocytes produce then active oxygen species and cytokines; they degranulate (releasing active enzymes such as myeloperoxidase), they express an increasing number of membrane receptors able to interact with endothelial cells and release a supplementary lot of inflammatory mediators (prostanoids, platelet activating factor, leukotrienes ... ).	Oxygen	75-81	myeloperoxidase	Homo sapiens	156-171
1336460-5	1992	The interaction of NO3- with the metal is weak; the nearest of its oxygen atoms being at a distance of 0.28 nm from the zinc ion.	Oxygen	67-73	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
1478367-9	1992	Forearm uptake of oxygen and glucose in the diabetic patients increased markedly after C-peptide administration but were unchanged after NaCl infusion.	Oxygen	18-24	insulin	Homo sapiens	87-96
1489869-4	1992	Another important stimulus for increased EPO production is a fall of the arterial oxygen tension caused by either cardiopulmonary disorders or by a decrease of the oxygen tension in the inspiratory gas.	Oxygen	82-88	erythropoietin	Homo sapiens	41-44
1489869-4	1992	Another important stimulus for increased EPO production is a fall of the arterial oxygen tension caused by either cardiopulmonary disorders or by a decrease of the oxygen tension in the inspiratory gas.	Oxygen	164-170	erythropoietin	Homo sapiens	41-44
1445904-3	1992	The present study determined the biosynthetic origin of the Chl b formyl oxygen in in vivo labeling experiments.	Oxygen	73-79	photochlorophyllide reductase subunit B	Chlorella vulgaris	60-65
1445904-8	1992	These results demonstrate that the isocyclic ring keto oxygen of both Chl a and Chl b, as well as the formyl oxygen of Chl b, is derived from O2.	Oxygen	55-61	photochlorophyllide reductase subunit B	Chlorella vulgaris	80-85
1445904-8	1992	These results demonstrate that the isocyclic ring keto oxygen of both Chl a and Chl b, as well as the formyl oxygen of Chl b, is derived from O2.	Oxygen	109-115	photochlorophyllide reductase subunit B	Chlorella vulgaris	119-124
1445904-8	1992	These results demonstrate that the isocyclic ring keto oxygen of both Chl a and Chl b, as well as the formyl oxygen of Chl b, is derived from O2.	Oxygen	142-144	photochlorophyllide reductase subunit B	Chlorella vulgaris	80-85
1445904-8	1992	These results demonstrate that the isocyclic ring keto oxygen of both Chl a and Chl b, as well as the formyl oxygen of Chl b, is derived from O2.	Oxygen	142-144	photochlorophyllide reductase subunit B	Chlorella vulgaris	119-124
1300562-1	1992	Renal erythropoietin production is dependent on local oxygen content of blood which activates so called "oxygen sensors".	Oxygen	54-60	erythropoietin	Homo sapiens	6-20
22217848-8	1992	All of these substitutions are associated with the conserved dioxygen binding region of the putative I helix predicted from the crystal structure of P450(cam).	Oxygen	61-69	calmodulin 3	Homo sapiens	149-158
1334678-5	1992	Phosphatidic acid (PA), the initial product of the PLD pathway, also appears to act as a second messenger by directly activating the NADPH oxidase responsible for generating O2-.	Oxygen	174-176	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	51-54
1304602-3	1992	Inhibition of the formation of H2O2 by SOD indicates that the formation of H2O2 and the consequent decrease of the cell survival was enhanced by O2-.	Oxygen	33-35	superoxide dismutase 1	Homo sapiens	39-42
1300562-1	1992	Renal erythropoietin production is dependent on local oxygen content of blood which activates so called "oxygen sensors".	Oxygen	105-111	erythropoietin	Homo sapiens	6-20
1304999-7	1992	It implicated that the oxygen free radical might be involved in the neuronal damage induced by Dopamine, since the O2- and H2O2 were excessively generated during the oxidative deamination of Dopamine and the free radical scavengers, SOD and GSH-Px were decreased concomitantly in the cerebral ischemic tissue.	Oxygen	23-29	glutathione peroxidase 1	Rattus norvegicus	241-247
1304999-7	1992	It implicated that the oxygen free radical might be involved in the neuronal damage induced by Dopamine, since the O2- and H2O2 were excessively generated during the oxidative deamination of Dopamine and the free radical scavengers, SOD and GSH-Px were decreased concomitantly in the cerebral ischemic tissue.	Oxygen	115-117	glutathione peroxidase 1	Rattus norvegicus	241-247
1330078-1	1992	Biosynthesis of myeloperoxidase (MPO), a myeloid lysosomal hemoprotein critical for the optimal oxygen-dependent microbicidal activity of human neutrophils, is incompletely understood.	Oxygen	96-102	myeloperoxidase	Homo sapiens	16-31
1385428-0	1992	Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.	Oxygen	103-109	superoxide dismutase 2, mitochondrial	Mus musculus	6-29
1385428-6	1992	The finding that increased Mn-SOD in distal respiratory epithelial cells confers protection from oxygen injury provides a basis for novel therapies to protect lung from injury during oxygen therapy of acute and chronic lung diseases.	Oxygen	97-103	superoxide dismutase 2, mitochondrial	Mus musculus	27-33
1385428-6	1992	The finding that increased Mn-SOD in distal respiratory epithelial cells confers protection from oxygen injury provides a basis for novel therapies to protect lung from injury during oxygen therapy of acute and chronic lung diseases.	Oxygen	183-189	superoxide dismutase 2, mitochondrial	Mus musculus	27-33
1330078-1	1992	Biosynthesis of myeloperoxidase (MPO), a myeloid lysosomal hemoprotein critical for the optimal oxygen-dependent microbicidal activity of human neutrophils, is incompletely understood.	Oxygen	96-102	myeloperoxidase	Homo sapiens	33-36
1463172-1	1992	The oxygen tension for half saturation (P50) was determined for venous blood in thirteen patients with the adult respiratory distress syndrome undergoing intensive therapy.	Oxygen	4-10	nuclear factor kappa B subunit 1	Homo sapiens	40-43
1423271-10	1992	These results indicate that enTNF exerts its intracellular protective effect against the heat-induced cytotoxicity by scavenging reactive oxygen with induced manganous superoxide dismutase in a manner similar to that found in cells treated with exogenous TNF.	Oxygen	138-144	tumor necrosis factor	Homo sapiens	30-33
1443154-3	1992	After vasopressin infusion, LDV signal and indexes of hemoglobin (IHb) and oxygen (ISO2) content in the gastric mucosa estimated by RS significantly decreased in parallel with the reduction of gastric mucosal blood flow (GMBF).	Oxygen	75-81	arginine vasopressin	Rattus norvegicus	6-17
1443116-6	1992	Local forearm oxygen uptake was 3.9 +/- 1.3 mumol.100 g-1 x min-1 in the basal period.	Oxygen	14-20	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
1467445-2	1992	We have measured the enthalpy of binding oxygen and carbon monoxide to horse myoglobin, human hemoglobin A0 and sperm whale myoglobin in phosphate buffer at pH 7.6, with the enzyme reducing system of Hayashi.	Oxygen	41-47	myoglobin	Equus caballus	77-86
1338273-6	1992	The results suggest that O2- might be scavenged both directly by iodination stimulators, and by other oxygen radicals produced by activation of myeloperoxidase-mediated reaction.	Oxygen	25-27	myeloperoxidase	Homo sapiens	144-159
1444645-6	1992	Both hepatocellular enzyme release and inhibition of mitochondrial respiration appear to be associated with the generation of reactive oxygen intermediates by the hepatocyte itself, because oxygen radical scavengers prevented these adverse effects of TNF alpha.	Oxygen	135-141	tumor necrosis factor	Rattus norvegicus	251-260
1404592-3	1992	In this study, we used the antioxidant pyrrolidine dithiocarbamate (PDTC) to investigate whether the activation of NF-kappa B by the viral transactivator Tax from human T-cell leukemia virus type I also depends on the production of reactive oxygen intermediates.	Oxygen	241-247	nuclear factor kappa B subunit 1	Homo sapiens	115-125
1424484-4	1992	Oxygen uptake was lower in the diabetic men than in the control men both at anaerobic threshold (15.0 +/- 0.8 vs. 18.8 +/- 1.0 ml min-1 kg-1, P &lt; 0.01) and at peak exercise (25.3 +/- 1.5 vs. 31.1 +/- 1.4 ml min-1 kg-1, P &lt; 0.01).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	130-140
1424484-4	1992	Oxygen uptake was lower in the diabetic men than in the control men both at anaerobic threshold (15.0 +/- 0.8 vs. 18.8 +/- 1.0 ml min-1 kg-1, P &lt; 0.01) and at peak exercise (25.3 +/- 1.5 vs. 31.1 +/- 1.4 ml min-1 kg-1, P &lt; 0.01).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	210-220
1331181-8	1992	These results provide evidence that reactive oxygen metabolites play an important role in the regulation of IL-8 production and suggest that reduction of IL-8 release may contribute to the beneficial effects of antioxidants in experimental models of inflammation and ischemia/reperfusion injury.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
1451223-5	1992	Mean oxygen consumption during haemodynamic catheterization was 4.1 +/- 0.4 ml.kg-1 x min-1 with an average individual variation of 10%.	Oxygen	5-11	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
1425445-1	1992	Endothelin (ET)-1, is a 21 amino acid vasoactive peptide subject to regulation by cellular oxygen tension.	Oxygen	91-97	endothelin 1	Rattus norvegicus	0-17
1416596-10	1992	After three weeks of culture, a 24-fold higher number of Thy1.2lo F4/80- MAC1- cells (indicative of murine stem and progenitor cells) was observed in the perfusion system as compared with static culture under ambient oxygen.	Oxygen	217-223	thymus cell antigen 1, theta	Mus musculus	57-63
1279431-5	1992	VEGF messenger RNA levels are dramatically increased within a few hours of exposing different cell cultures to hypoxia and return to background when normal oxygen supply is resumed.	Oxygen	156-162	vascular endothelial growth factor A	Homo sapiens	0-4
1356437-2	1992	The crystal structure of D27E ecDHFR in a binary complex with methotrexate shows that the side-chain oxygen atoms of Glu27 are in almost precisely the same location as those of Asp27 in the wild-type enzyme.	Oxygen	101-107	dihydrofolate reductase	Escherichia coli	30-36
1390940-0	1992	Hemoglobin Dallas (alpha 97(G4)Asn--&gt;Lys): functional characterization of a high oxygen affinity natural mutant.	Oxygen	84-90	chromosome 6 open reading frame 47	Homo sapiens	19-30
1416596-10	1992	After three weeks of culture, a 24-fold higher number of Thy1.2lo F4/80- MAC1- cells (indicative of murine stem and progenitor cells) was observed in the perfusion system as compared with static culture under ambient oxygen.	Oxygen	217-223	integrin alpha M	Mus musculus	73-77
1414895-3	1992	However, long-term ACE inhibition increases blood flow to skeletal muscle, and this increase is closely correlated with improvement in systemic oxygen consumption.	Oxygen	144-150	angiotensin I converting enzyme	Homo sapiens	19-22
1395103-1	1992	We studied the effect of recombinant tumour necrosis factor-alpha (TNF-alpha) on the production of reactive oxygen metabolites (ROM) by human PMN exposed in vitro to chrysotile and crocidolite asbestos fibres, quartz dusts and opsonized zymosan.	Oxygen	108-114	tumor necrosis factor	Homo sapiens	67-76
1415724-2	1992	During early postnatal exposure to &gt; 95% O2, the lung activity of Cu,Zn SOD, CAT, and GP increases.	Oxygen	44-46	superoxide dismutase 1	Rattus norvegicus	69-78
1415724-2	1992	During early postnatal exposure to &gt; 95% O2, the lung activity of Cu,Zn SOD, CAT, and GP increases.	Oxygen	44-46	catalase	Rattus norvegicus	80-83
1441861-9	1992	Twenty-minute flushing with oxygen (8 l min-1) decreased effluent gas concentrations below 5 p.p.m.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	40-45
1516155-5	1992	The components of low-antithrombin III affinity heparan sulfate generated during exposure to 3% oxygen were increased in size compared with the corresponding low-affinity components generated during the 21% oxygen exposure for both BPAECs and BAECs.	Oxygen	96-102	serpin family C member 1	Bos taurus	22-38
1398214-4	1992	Paraquat or O2 inhibition is alleviated respectively by desferrioxamine-Mn (a SOD mimic) and tocopherol.	Oxygen	12-14	superoxide dismutase 1	Homo sapiens	78-81
1331388-12	1992	Evolution of O2 upon addition of catalase to the illuminated solution confirmed the ultimate formation of hydrogen peroxide.	Oxygen	13-15	catalase	Homo sapiens	33-41
1399119-0	1992	Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen.	Oxygen	111-117	epidermal growth factor receptor	Homo sapiens	9-41
1530643-0	1992	Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.	Oxygen	83-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
1328295-6	1992	This cytochrome P-450 mediated activity was oxygen- and NADPH-dependent and was inhibited 68% by 5 microM ketoconazole (P = 0.0035, n = 8) and 51% by carbon monoxide (P = 0.02, n = 6).	Oxygen	44-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	5-21
1384351-7	1992	Exposing individual medium components to high O2 demonstrated that purified natural ECGF and recombinant acidic or basic FGF were all inactivated by O2.	Oxygen	46-48	fibroblast growth factor 1	Homo sapiens	84-88
1396679-1	1992	Thrombin, a peptide with native protease activity, caused a rapid (less than 1 min) increase in glycogenolysis of about 30%, assessed from rates of production of glucose+lactate+pyruvate, and in oxygen uptake in perfused rat liver.	Oxygen	195-201	coagulation factor II	Rattus norvegicus	0-8
1423468-6	1992	The standard error of the mean of the maximal oxygen consumption estimate from the 2000 m walk is 3.44 ml.kg-1 x min-1 (5.7%) and from the running time of the same distance 3.49 ml.kg-1 x min-1 (5.8%).	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
1423468-6	1992	The standard error of the mean of the maximal oxygen consumption estimate from the 2000 m walk is 3.44 ml.kg-1 x min-1 (5.7%) and from the running time of the same distance 3.49 ml.kg-1 x min-1 (5.8%).	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	188-193
1415559-1	1992	We have previously demonstrated that tracheal insufflation of interleukin-1 alpha (IL-1) enhances pulmonary Mn superoxide dismutase (Mn SOD) activity and protects rats against O2 toxicity (M. F. Tsan, C. Y. Lee, and J. E. White.	Oxygen	176-178	interleukin 1 alpha	Rattus norvegicus	62-81
1384351-7	1992	Exposing individual medium components to high O2 demonstrated that purified natural ECGF and recombinant acidic or basic FGF were all inactivated by O2.	Oxygen	46-48	fibroblast growth factor 1	Homo sapiens	121-124
1384351-7	1992	Exposing individual medium components to high O2 demonstrated that purified natural ECGF and recombinant acidic or basic FGF were all inactivated by O2.	Oxygen	149-151	fibroblast growth factor 1	Homo sapiens	84-88
1416035-3	1992	For such sensors, potentiometric oxygen response is attributed to a mixed potential originating from the underlying platinum electrode surface as well as a change in redox potential of the Co(II)-tetren-doped film as the complex binds oxygen reversibly.	Oxygen	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
1384351-7	1992	Exposing individual medium components to high O2 demonstrated that purified natural ECGF and recombinant acidic or basic FGF were all inactivated by O2.	Oxygen	149-151	fibroblast growth factor 1	Homo sapiens	121-124
1416035-3	1992	For such sensors, potentiometric oxygen response is attributed to a mixed potential originating from the underlying platinum electrode surface as well as a change in redox potential of the Co(II)-tetren-doped film as the complex binds oxygen reversibly.	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
1445378-0	1992	Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen.	Oxygen	80-86	endothelin 1	Homo sapiens	49-61
1514720-0	1992	The clinical implications of continuous central venous oxygen saturation during human CPR.	Oxygen	55-61	cytochrome p450 oxidoreductase	Homo sapiens	86-89
1514720-1	1992	STUDY OBJECTIVE: The purpose of this study was to observe, measure, and describe the changes in central venous oxygen saturation during CPR and immediately after return of spontaneous circulation.	Oxygen	111-117	cytochrome p450 oxidoreductase	Homo sapiens	136-139
1514720-15	1992	CONCLUSION: Continuous central venous oxygen saturation monitoring can serve as a reliable indicator of return of spontaneous circulation during CPR in human beings.	Oxygen	38-44	cytochrome p450 oxidoreductase	Homo sapiens	145-148
1445378-4	1992	The molecular weight of ET-1 exposed to oxygen was identical to that of ET-1.	Oxygen	40-46	endothelin 1	Homo sapiens	24-28
1279350-1	1992	Hypoxia-ischemia induced by unilateral carotid ligation followed by either 15 (moderate) or 90 (severe) min exposure to 8% oxygen was associated with induction of IGF-BP 2 mRNA expression.	Oxygen	123-129	insulin-like growth factor binding protein 2	Rattus norvegicus	163-171
1499941-1	1992	Cellular protection from immune-generated oxygen free radicals is initiated by the reduction of oxygen radicals by manganese superoxide dismutase (MnSOD) and copper/zinc superoxide dismutase (Cu/ZnSOD).	Oxygen	42-48	superoxide dismutase 1	Rattus norvegicus	192-200
1522234-5	1992	We now show that isolated human blood monocytes respond to such an oxygen stress with augmented production of IL-8.	Oxygen	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
1400046-11	1992	Therefore, exposing humans continuously to an inspiratory O2 fraction of 0.105 for 120 min or intermittently for 240 min provides a sufficient stimulus to increase production of EPO.	Oxygen	58-60	erythropoietin	Homo sapiens	178-181
1522234-11	1992	The association of anoxic preconditioning and oxygen stress with augmented production of monocyte-derived IL-8 support the potential role for ischemia-reperfusion and hyperoxia-induced IL-8 production in vivo, providing a possible mechanism for PMN migration/activation in disease states characterized by altered tissue oxygenation.	Oxygen	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
1522234-11	1992	The association of anoxic preconditioning and oxygen stress with augmented production of monocyte-derived IL-8 support the potential role for ischemia-reperfusion and hyperoxia-induced IL-8 production in vivo, providing a possible mechanism for PMN migration/activation in disease states characterized by altered tissue oxygenation.	Oxygen	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
1410844-1	1992	We investigated the effects of acute hypoxia (10% O2) on plasma level of atrial natriuretic peptide (ANP) and pulmonary hemodynamics in five subjects with a history of high-altitude pulmonary edema (HAPE).	Oxygen	50-52	natriuretic peptide A	Homo sapiens	73-99
1405338-3	1992	The present study examined both basal and FMLP-stimulated rise in cytosolic calcium ([Ca2+]i) and O2 consumption of PMNL from normal subjects and hemodialysis patients and from CRF rats, and evaluated the potential role of secondary hyperparathyroidism of CRF on these properties of PMNL.	Oxygen	98-100	formyl peptide receptor 1	Homo sapiens	42-46
1405338-5	1992	Basal and FMLP-stimulated O2 consumption were significantly lower in CRF subjects and rats than in normals.	Oxygen	26-28	formyl peptide receptor 1	Homo sapiens	10-14
16652965-0	1992	Involvement of Molecular Oxygen in the Enzyme-Catalyzed NADH Oxidation and Ferric Leghemoglobin Reduction.	Oxygen	25-31	leghemoglobin A	Glycine max	82-95
1410844-3	1992	The plasma ANP levels in HAPE-susceptible subjects rose significantly in response to 10% O2 (from 34.8 +/- 5.4 to 51.4 +/- 7.3 pg.ml-1; P less than 0.05), not associated with any increase in either atrial pressure.	Oxygen	89-91	natriuretic peptide A	Homo sapiens	11-14
1325119-2	1992	Compared with normoxia (20% O2), EPO production by Hep G2 cells during a 72-h incubation was stimulated fivefold by exposure to low oxygen tension (1% O2) and nearly threefold by exposure to cobalt chloride (100 microM).	Oxygen	28-30	erythropoietin	Homo sapiens	33-36
1325119-2	1992	Compared with normoxia (20% O2), EPO production by Hep G2 cells during a 72-h incubation was stimulated fivefold by exposure to low oxygen tension (1% O2) and nearly threefold by exposure to cobalt chloride (100 microM).	Oxygen	132-138	erythropoietin	Homo sapiens	33-36
1325119-2	1992	Compared with normoxia (20% O2), EPO production by Hep G2 cells during a 72-h incubation was stimulated fivefold by exposure to low oxygen tension (1% O2) and nearly threefold by exposure to cobalt chloride (100 microM).	Oxygen	151-153	erythropoietin	Homo sapiens	33-36
1325119-3	1992	IGF-I caused a concentration-dependent attenuation of EPO formation under normoxic conditions and inhibited (maximally 50%) EPO production stimulated by either low oxygen tension or cobalt [half-maximal effect (ED50) approximately 5 nM].	Oxygen	164-170	insulin like growth factor 1	Homo sapiens	0-5
1510136-1	1992	This study was designed to test the hypothesis that the oxygen free radical scavengers superoxide dismutase (SOD) and catalase may reduce myocardial "stunning" after exercise-induced ischemia.	Oxygen	56-62	catalase	Canis lupus familiaris	118-126
1325119-3	1992	IGF-I caused a concentration-dependent attenuation of EPO formation under normoxic conditions and inhibited (maximally 50%) EPO production stimulated by either low oxygen tension or cobalt [half-maximal effect (ED50) approximately 5 nM].	Oxygen	164-170	erythropoietin	Homo sapiens	124-127
1325119-6	1992	IGF-I (100 pM-100 nM) stimulated the incorporation of radiolabeled alanine as a measure for total protein synthesis, 3H-labeled thymidine incorporation into DNA, and glycogen synthesis at 20 and 1% O2 in a concentration-dependent fashion.	Oxygen	198-200	insulin like growth factor 1	Homo sapiens	0-5
1325119-10	1992	In summary, IGFs and insulin exert a negative control function on oxygen-regulated EPO production in Hep G2 cells.	Oxygen	66-72	insulin	Homo sapiens	21-28
1325119-10	1992	In summary, IGFs and insulin exert a negative control function on oxygen-regulated EPO production in Hep G2 cells.	Oxygen	66-72	erythropoietin	Homo sapiens	83-86
1322671-1	1992	OBJECTIVE: Platelet-activating factor (PAF), which stimulates the release of tissue-destructive enzymes and reactive oxygen metabolites from neutrophils, was investigated for its role in neutrophil-mediated cartilage breakdown.	Oxygen	117-123	PCNA-associated factor	Bos taurus	11-37
1330032-0	1992	Oxygen diffusion-concentration product in rhodopsin as observed by a pulse ESR spin labeling method.	Oxygen	0-6	rhodopsin	Homo sapiens	42-51
1519724-4	1992	Oxygen, 4 l.min-1, was administrated by paediatric face mask.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	12-17
1322671-1	1992	OBJECTIVE: Platelet-activating factor (PAF), which stimulates the release of tissue-destructive enzymes and reactive oxygen metabolites from neutrophils, was investigated for its role in neutrophil-mediated cartilage breakdown.	Oxygen	117-123	PCNA-associated factor	Bos taurus	39-42
1330032-1	1992	Permeation of molecular oxygen in rhodopsin, an integral membrane protein, has been investigated by monitoring the bimolecular collision rate between molecular oxygen and the nitroxide spin label using a pulse electron spin resonance (ESR) T1 method.	Oxygen	24-30	rhodopsin	Homo sapiens	34-43
1330032-1	1992	Permeation of molecular oxygen in rhodopsin, an integral membrane protein, has been investigated by monitoring the bimolecular collision rate between molecular oxygen and the nitroxide spin label using a pulse electron spin resonance (ESR) T1 method.	Oxygen	160-166	rhodopsin	Homo sapiens	34-43
1393291-6	1992	The influence of increasing the oxygen tension to 16% (that prevalent at birth) on the response to endothelin-1 on the umbilical arteries was also investigated.	Oxygen	32-38	endothelin 1	Homo sapiens	99-111
1330032-4	1992	W-values at the beta-ionone binding site in spin-labeled rhodopsin are in the range of 0.02-0.13 microseconds-1, which are 10-60 times smaller than W"s in water and 1.1-20 times smaller than in model membranes in the gel phase, indicating that membrane proteins create significant permeation resistance to transport of molecular oxygen inside and across the membrane.	Oxygen	329-335	rhodopsin	Homo sapiens	57-66
1330032-5	1992	W(thereby the oxygen diffusion-concentration product) is larger in the meta II-enriched sample than in rhodopsin, indicating light-induced conformational changes of opsin around the beta-ionone binding site.	Oxygen	14-20	rhodopsin	Homo sapiens	103-112
1326481-6	1992	We also determined the amount of active oxygen species produced by PMNLs in response to TPA.	Oxygen	40-46	plasminogen activator, tissue type	Homo sapiens	88-91
1643937-5	1992	Under hypoxic conditions, serum EPO levels rose over 4 h with the change from baseline first becoming significant at 2 h. The log of serum EPO response showed an inverse correlation with the level of arterial oxygen saturation.	Oxygen	209-215	erythropoietin	Homo sapiens	32-35
1643937-5	1992	Under hypoxic conditions, serum EPO levels rose over 4 h with the change from baseline first becoming significant at 2 h. The log of serum EPO response showed an inverse correlation with the level of arterial oxygen saturation.	Oxygen	209-215	erythropoietin	Homo sapiens	139-142
1389825-10	1992	Oxygen by mask at 4 litre min-1 maintained an average saturation &gt; or = 95% in most, but not all, of the patients.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	26-31
1641471-3	1992	We show that the cytotoxic effect of TNF toward TNF-sensitive L929 cells is blocked under hypoxic conditions, suggesting a critical role of molecular oxygen and reactive oxygen species.	Oxygen	150-156	tumor necrosis factor	Mus musculus	37-40
1328424-10	1992	SOD is the enzyme that catalyzes the dismutation reaction of superoxide anion radicals: 2O2- + 2H(+)----H2O2 + O2.	Oxygen	89-91	superoxide dismutase 1	Homo sapiens	0-3
1422225-6	1992	rhIL-8 was assessed for biological efficacy by three criteria: (a) ability to induce chemotaxis in human neutrophils, (b) ability to induce oxygen burst metabolism, and (c) ability to be recognized by purified rabbit antibody generated against monocyte-derived IL-8.	Oxygen	140-146	C-X-C motif chemokine ligand 8	Homo sapiens	2-6
1641471-3	1992	We show that the cytotoxic effect of TNF toward TNF-sensitive L929 cells is blocked under hypoxic conditions, suggesting a critical role of molecular oxygen and reactive oxygen species.	Oxygen	150-156	tumor necrosis factor	Mus musculus	48-51
1328778-6	1992	As expected, stimulated (FMLP 0.1 microM) O2- generation by neutrophils from the elderly was significantly decreased compared with young controls (34 +/- 7% decrease, n = 6, P less than 0.04).	Oxygen	42-44	formyl peptide receptor 1	Homo sapiens	25-29
1627798-7	1992	In suspension cultures, reduced oxygen increased cumulative total cell production by 125% and 167%, and cumulative progenitor production by 68% and 21%, with IL-1/IL-3 and IL-3/IL-6, respectively.	Oxygen	32-38	interleukin 6	Homo sapiens	172-181
1627798-14	1992	Endogenous production of IL-6 was significantly higher under 5% O2 in both suspension and stromal cultures, and IL-6 production was increased threefold by the addition of IL-1/IL-3.	Oxygen	64-66	interleukin 6	Homo sapiens	25-29
1353610-1	1992	The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-.	Oxygen	115-117	superoxide dismutase 1	Homo sapiens	18-38
1353610-1	1992	The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-.	Oxygen	115-117	superoxide dismutase 1	Homo sapiens	40-43
1626552-2	1992	A review of available clinical data has shown that, following epoetin therapy, peak oxygen consumption, a principal indicator of exercise ability, increased by approximately 50% as the hematocrit level increased.	Oxygen	84-90	erythropoietin	Homo sapiens	62-69
1322122-2	1992	The increase in EPO synthesis induced by Co2+ (50 microM), Ni2+ (300 microM) or oxygen (1% O2) was inhibited by the presence of ZnCl2 (50-150 microM) in the tissue-culture medium, whereas basal EPO synthesis was unaffected.	Oxygen	80-86	erythropoietin	Homo sapiens	16-19
1636726-0	1992	IL-6 enhances TNF-alpha- and IL-1-induced increase of Mn superoxide dismutase mRNA and O2 tolerance.	Oxygen	87-89	interleukin 6	Rattus norvegicus	0-4
1636726-0	1992	IL-6 enhances TNF-alpha- and IL-1-induced increase of Mn superoxide dismutase mRNA and O2 tolerance.	Oxygen	87-89	tumor necrosis factor	Rattus norvegicus	14-23
1636726-8	1992	71: 688-697, 1991) that tracheal insufflation of 5 micrograms of TNF-alpha or 1 microgram of IL-1 markedly protects rats against O2 toxicity and enhances pulmonary Mn superoxide dismutase (Mn SOD) activity.	Oxygen	129-131	tumor necrosis factor	Rattus norvegicus	65-74
1636726-9	1992	We now report that TNF-alpha and IL-1 at subprotective doses, e.g., 1 and 0.2 micrograms, respectively, act synergistically in protecting rats against O2 toxicity.	Oxygen	151-153	tumor necrosis factor	Rattus norvegicus	19-28
1636726-12	1992	However, IL-6 markedly enhances TNF-alpha- and IL-1-induced increases in Mn SOD mRNA levels and O2 tolerance.	Oxygen	96-98	interleukin 6	Rattus norvegicus	9-13
1636726-12	1992	However, IL-6 markedly enhances TNF-alpha- and IL-1-induced increases in Mn SOD mRNA levels and O2 tolerance.	Oxygen	96-98	tumor necrosis factor	Rattus norvegicus	32-41
1322122-2	1992	The increase in EPO synthesis induced by Co2+ (50 microM), Ni2+ (300 microM) or oxygen (1% O2) was inhibited by the presence of ZnCl2 (50-150 microM) in the tissue-culture medium, whereas basal EPO synthesis was unaffected.	Oxygen	80-86	erythropoietin	Homo sapiens	194-197
1322122-2	1992	The increase in EPO synthesis induced by Co2+ (50 microM), Ni2+ (300 microM) or oxygen (1% O2) was inhibited by the presence of ZnCl2 (50-150 microM) in the tissue-culture medium, whereas basal EPO synthesis was unaffected.	Oxygen	91-93	erythropoietin	Homo sapiens	16-19
1641069-3	1992	A clear response of GH to exercise was registered already at an intensity of 50% of maximal oxygen uptake (VO2max) with a maximal response at 70% VO2max and no further effect at 90% VO2max.	Oxygen	92-98	growth hormone 1	Homo sapiens	20-22
1505161-5	1992	Peak O2 consumption of the patients was 14.9 +/- 5.3 ml min-1 kg-1 and that of controls 33.6 +/- 7.5 ml min-1 kg-1.	Oxygen	5-7	CD59 molecule (CD59 blood group)	Homo sapiens	56-66
1319953-7	1992	Reactive oxygen metabolite-induced cell damage was reduced by catalase but not by superoxide dismutase.	Oxygen	9-15	catalase	Rattus norvegicus	62-70
1512080-1	1992	Flow cytometry and the fluorescent dyes DCF and R123 were used to examine oxygen metabolite production in human leukocytes and T-lymphoblastoid Jurkat cells, activated by PMA or by FMLP.	Oxygen	74-80	formyl peptide receptor 1	Homo sapiens	181-185
1405595-8	1992	Plasma TFE subjected to glow discharge in O2 and carrying negatively charged functional groups on graft surfaces, exhibited a fivefold increase in fibronectin and laminin binding.	Oxygen	42-44	fibronectin 1	Homo sapiens	147-158
1606144-7	1992	The pro-S oxygen atom of the two phosphonate inhibitors and of the phosphinate group of the StaP inhibitor make very short contact distances (approximately 2.4 A) to the carboxyl oxygen atom, O delta 1, of Asp33 on penicillopepsin.	Oxygen	10-16	cytoglobin	Homo sapiens	92-96
20732133-3	1992	Leakage of lactate dehydrogenase and aspartate aminotransferase could be prevented during a 1-hr perfusion when either chemical oxygen carriers or erythrocytes were added.	Oxygen	128-134	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	37-63
16414719-4	1992	A number of pathways have been described e.g. the error-prone SOS repair (that lacks fidelity of repair process),the error-proof adaptive repair of alkylated DNA and inducible response to oxygen radical damage in DNA.	Oxygen	188-194	xylosyltransferase 2	Homo sapiens	62-65
1606144-7	1992	The pro-S oxygen atom of the two phosphonate inhibitors and of the phosphinate group of the StaP inhibitor make very short contact distances (approximately 2.4 A) to the carboxyl oxygen atom, O delta 1, of Asp33 on penicillopepsin.	Oxygen	179-185	cytoglobin	Homo sapiens	92-96
1376358-7	1992	NK peptides increased contractility in longitudinally oriented strips of jejunal smooth muscle with an order of potency: [Sar9,Met(O2)11]SP greater than SP greater than Arg-NKB = [beta-Ala8]NKA4-10 greater than or equal to NKB = NKA (SP EC50 = 11 nM).	Oxygen	131-133	tachykinin precursor 1	Homo sapiens	137-139
1596009-5	1992	Oxygen consumption and delivery both increased significantly at 3 h (219 +/- 17 and 1,030 +/- 43 ml/min.min2) and 5 h (203 +/- 7 and 949 +/- 48 ml/min.min2) (p less than or equal to 0.035), whereas oxygen extraction fell at 3 h (p = 0.041).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	104-108
1596009-5	1992	Oxygen consumption and delivery both increased significantly at 3 h (219 +/- 17 and 1,030 +/- 43 ml/min.min2) and 5 h (203 +/- 7 and 949 +/- 48 ml/min.min2) (p less than or equal to 0.035), whereas oxygen extraction fell at 3 h (p = 0.041).	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	151-155
1596009-5	1992	Oxygen consumption and delivery both increased significantly at 3 h (219 +/- 17 and 1,030 +/- 43 ml/min.min2) and 5 h (203 +/- 7 and 949 +/- 48 ml/min.min2) (p less than or equal to 0.035), whereas oxygen extraction fell at 3 h (p = 0.041).	Oxygen	198-204	CD59 molecule (CD59 blood group)	Homo sapiens	151-155
1620103-2	1992	The factor is encoded by two genes in Saccharomyces cerevisiae, called TIF51A and TIF51B, which are regulated reciprocally by oxygen and by heme.	Oxygen	126-132	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	82-88
1434581-4	1992	Significant increases (p less than 0.001) in maximal oxygen uptake occurred in both the aerobics (+3.9 ml/kg-1/min-1) and walk-jog group (+3.4 ml/kg-1/min-1), while no significant change was observed in the control group.	Oxygen	53-59	CD59 molecule (CD59 blood group)	Homo sapiens	111-116
1434581-4	1992	Significant increases (p less than 0.001) in maximal oxygen uptake occurred in both the aerobics (+3.9 ml/kg-1/min-1) and walk-jog group (+3.4 ml/kg-1/min-1), while no significant change was observed in the control group.	Oxygen	53-59	CD59 molecule (CD59 blood group)	Homo sapiens	151-156
1591427-13	1992	AMFs (e.g., blood doping, epoetin) enhance aerobic metabolism and endurance by increasing the oxygen-carrying capacity of the blood.	Oxygen	94-100	erythropoietin	Homo sapiens	26-33
1328002-11	1992	The multiple lines of defense against toxic oxygen intermediates consist of enzymatic systems, glutathione peroxidase, catalase and superoxide dismutase, and furthermore involves antioxidant capacities such as those of vitamin E and vitamin C.	Oxygen	44-50	catalase	Homo sapiens	119-127
1318017-2	1992	This appears as an inhibition of substrate oxidation (cytochrome c) or reduction (O2) rates which, in the first few turnovers, can be largely removed upon addition of valinomycin, a specific K+ carrier.	Oxygen	82-84	cytochrome c, somatic	Homo sapiens	54-66
1317101-2	1992	During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM).	Oxygen	98-104	erythropoietin	Homo sapiens	26-29
1590418-1	1992	To investigate the effects of anemia correction with recombinant human erythropoietin (rhEPO) on both cerebral blood flow and oxygen metabolism in hemodialysis (HD) patients, the regional cerebral blood flow (rCBF), oxygen extraction (rOEF), and metabolic rate for oxygen (rCMRO2) were measured by positron emission tomography in five HD patients, and the data were compared with eight nondemented controls who had neither anemia nor uremia.	Oxygen	126-132	erythropoietin	Homo sapiens	71-85
1499763-0	1992	[Participation of cholecystokinin and pentagastrin in the regulation of the liver blood supply and oxygen consumption].	Oxygen	99-105	cholecystokinin	Homo sapiens	18-33
1499763-4	1992	Cholecystokinin and pentagastrin in the same series of experiments decrease and increase the oxygen consumption by the liver depending on its functional state.	Oxygen	93-99	cholecystokinin	Homo sapiens	0-15
1607083-6	1992	Supplemental oxygen given at a rate of 2 liters.min-1 was as effective as that given at a rate of 3 liters.min-1 in preventing significant desaturation, as previously defined, during the procedure.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	48-53
1607083-6	1992	Supplemental oxygen given at a rate of 2 liters.min-1 was as effective as that given at a rate of 3 liters.min-1 in preventing significant desaturation, as previously defined, during the procedure.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
1499763-5	1992	It is supposed that correction of the oxygen supply of hepatocytes by the action of pentagastrin is realized due to changes in the blood flow in the liver artery, and under the cholecystokinin effect it is made by the change of the oxygen extraction.	Oxygen	232-238	cholecystokinin	Homo sapiens	177-192
1601798-0	1992	Role of tumor necrosis factor in oxygen toxicity.	Oxygen	33-39	tumor necrosis factor	Mus musculus	8-29
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	206-208	interleukin 2	Homo sapiens	91-104
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	206-208	interleukin 2	Homo sapiens	106-110
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	221-223	interleukin 2	Homo sapiens	91-104
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	221-223	interleukin 2	Homo sapiens	106-110
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	346-352	interleukin 2	Homo sapiens	91-104
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	346-352	interleukin 2	Homo sapiens	106-110
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	221-223	interleukin 2	Homo sapiens	91-104
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	221-223	interleukin 2	Homo sapiens	106-110
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	404-410	interleukin 2	Homo sapiens	91-104
1500092-1	1992	In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen tension (100 mmHg) and 2% O2 equal to venous blood oxygen tension (40 mmHg).	Oxygen	404-410	interleukin 2	Homo sapiens	106-110
1500092-3	1992	LAK cells were induced by IL-2 over 5 days at 20% O2, at which time the LAK cells were further stimulated by IL-2 in 2% O2 and 20% O2.	Oxygen	120-122	interleukin 2	Homo sapiens	109-113
1500092-3	1992	LAK cells were induced by IL-2 over 5 days at 20% O2, at which time the LAK cells were further stimulated by IL-2 in 2% O2 and 20% O2.	Oxygen	120-122	interleukin 2	Homo sapiens	109-113
1601798-1	1992	mRNA from lungs of mice exposed to high-dose oxygen (greater than 95%) for 3 days demonstrated increased expression of the genes for tumor necrosis factor (TNF), interleukin-1, and interleukin-6 compared with mRNA from lungs of mice exposed to room air.	Oxygen	45-51	tumor necrosis factor	Mus musculus	133-154
1601798-1	1992	mRNA from lungs of mice exposed to high-dose oxygen (greater than 95%) for 3 days demonstrated increased expression of the genes for tumor necrosis factor (TNF), interleukin-1, and interleukin-6 compared with mRNA from lungs of mice exposed to room air.	Oxygen	45-51	tumor necrosis factor	Mus musculus	156-159
1601798-1	1992	mRNA from lungs of mice exposed to high-dose oxygen (greater than 95%) for 3 days demonstrated increased expression of the genes for tumor necrosis factor (TNF), interleukin-1, and interleukin-6 compared with mRNA from lungs of mice exposed to room air.	Oxygen	45-51	interleukin 6	Mus musculus	181-194
1611013-2	1992	The aim of this study was to investigate whether oxygen inhalation could improve hepatic function during vasopressin infusion.	Oxygen	49-55	arginine vasopressin	Homo sapiens	105-116
1601798-2	1992	Daily treatment of mice exposed to high-dose oxygen with an antibody to TNF improved survival compared with mice receiving a similar dose of control immunoglobulin G. Pretreatment of mice with repetitive sublethal intraperitoneal doses of recombinant human TNF for 3 days or a single intravenous dose followed by exposure to high-dose oxygen afforded a significant survival advantage compared with high-dose oxygen-exposed mice pretreated with vehicle or interleukin-1.	Oxygen	45-51	tumor necrosis factor	Mus musculus	72-75
1601798-2	1992	Daily treatment of mice exposed to high-dose oxygen with an antibody to TNF improved survival compared with mice receiving a similar dose of control immunoglobulin G. Pretreatment of mice with repetitive sublethal intraperitoneal doses of recombinant human TNF for 3 days or a single intravenous dose followed by exposure to high-dose oxygen afforded a significant survival advantage compared with high-dose oxygen-exposed mice pretreated with vehicle or interleukin-1.	Oxygen	45-51	tumor necrosis factor	Mus musculus	257-260
1601798-2	1992	Daily treatment of mice exposed to high-dose oxygen with an antibody to TNF improved survival compared with mice receiving a similar dose of control immunoglobulin G. Pretreatment of mice with repetitive sublethal intraperitoneal doses of recombinant human TNF for 3 days or a single intravenous dose followed by exposure to high-dose oxygen afforded a significant survival advantage compared with high-dose oxygen-exposed mice pretreated with vehicle or interleukin-1.	Oxygen	335-341	tumor necrosis factor	Mus musculus	72-75
1601798-2	1992	Daily treatment of mice exposed to high-dose oxygen with an antibody to TNF improved survival compared with mice receiving a similar dose of control immunoglobulin G. Pretreatment of mice with repetitive sublethal intraperitoneal doses of recombinant human TNF for 3 days or a single intravenous dose followed by exposure to high-dose oxygen afforded a significant survival advantage compared with high-dose oxygen-exposed mice pretreated with vehicle or interleukin-1.	Oxygen	335-341	tumor necrosis factor	Mus musculus	72-75
1601798-3	1992	The repetitive intraperitoneal TNF pretreatment reduced the development of interstitial pneumonitis, pulmonary edema, and lung weight gain associated with oxygen toxicity and enhanced expression of the gene for the free radical protective enzyme manganous superoxide dismutase in lung tissue, a gene that is augmented as mice are exposed to high-dose oxygen.	Oxygen	155-161	tumor necrosis factor	Mus musculus	31-34
1601798-3	1992	The repetitive intraperitoneal TNF pretreatment reduced the development of interstitial pneumonitis, pulmonary edema, and lung weight gain associated with oxygen toxicity and enhanced expression of the gene for the free radical protective enzyme manganous superoxide dismutase in lung tissue, a gene that is augmented as mice are exposed to high-dose oxygen.	Oxygen	351-357	tumor necrosis factor	Mus musculus	31-34
1601798-4	1992	Furthermore a single intravenous dose of TNF 24 h after oxygen exposure was still protective.	Oxygen	56-62	tumor necrosis factor	Mus musculus	41-44
1601798-5	1992	The results suggest that the toxicity of oxygen therapy can be partially ameliorated by either treatment with anti-TNF antibody or pretreatment and early treatment with TNF.	Oxygen	41-47	tumor necrosis factor	Mus musculus	115-118
1601798-5	1992	The results suggest that the toxicity of oxygen therapy can be partially ameliorated by either treatment with anti-TNF antibody or pretreatment and early treatment with TNF.	Oxygen	41-47	tumor necrosis factor	Mus musculus	169-172
1601798-6	1992	These findings are consistent with the hypothesis that oxygen exposure induces TNF, which causes part of the toxicity of high-dose oxygen, and that pretreatment or early treatment with TNF induces the gene for an enzyme that recently has been shown to be very effective in protecting mice from the toxicity of oxygen.	Oxygen	55-61	tumor necrosis factor	Mus musculus	79-82
1601798-6	1992	These findings are consistent with the hypothesis that oxygen exposure induces TNF, which causes part of the toxicity of high-dose oxygen, and that pretreatment or early treatment with TNF induces the gene for an enzyme that recently has been shown to be very effective in protecting mice from the toxicity of oxygen.	Oxygen	131-137	tumor necrosis factor	Mus musculus	79-82
1601798-6	1992	These findings are consistent with the hypothesis that oxygen exposure induces TNF, which causes part of the toxicity of high-dose oxygen, and that pretreatment or early treatment with TNF induces the gene for an enzyme that recently has been shown to be very effective in protecting mice from the toxicity of oxygen.	Oxygen	131-137	tumor necrosis factor	Mus musculus	185-188
1601798-6	1992	These findings are consistent with the hypothesis that oxygen exposure induces TNF, which causes part of the toxicity of high-dose oxygen, and that pretreatment or early treatment with TNF induces the gene for an enzyme that recently has been shown to be very effective in protecting mice from the toxicity of oxygen.	Oxygen	131-137	tumor necrosis factor	Mus musculus	79-82
1601798-6	1992	These findings are consistent with the hypothesis that oxygen exposure induces TNF, which causes part of the toxicity of high-dose oxygen, and that pretreatment or early treatment with TNF induces the gene for an enzyme that recently has been shown to be very effective in protecting mice from the toxicity of oxygen.	Oxygen	131-137	tumor necrosis factor	Mus musculus	185-188
1373333-8	1992	By Northern blot analysis, Epo messenger RNA levels in Hep3B cells grown in 1% O2 were decreased when concurrently exposed to either IL-1 alpha or TNF-alpha.	Oxygen	79-81	erythropoietin	Homo sapiens	27-30
1603620-2	1992	We studied the effect of in vivo exposure to 85% oxygen for 72 h on the activities of the antioxidant enzymes, glutathione peroxidase, catalase and superoxide dismutase (SOD), in alveolar type II cells and whole lung from adult and neonatal rats.	Oxygen	49-55	catalase	Rattus norvegicus	135-143
1630163-8	1992	CONCLUSIONS: These results suggest that the response of the growth hormone to exercise is a function of maximum oxygen consumption although this only explains 24% of the variants of the growth hormone.	Oxygen	112-118	growth hormone 1	Homo sapiens	60-74
1630163-9	1992	Despite important hormonal and metabolic mobilization during exercise, no model of multiple regression has been found which substantially improves the association found between the growth hormone and maximum oxygen consumption.	Oxygen	208-214	growth hormone 1	Homo sapiens	181-195
1318656-7	1992	To evaluate a possible direct effect on the pituitary, IL-6 was incubated in vitro with hemipituitaries under an atmosphere of 95% O2/5% CO2.	Oxygen	131-133	interleukin 6	Homo sapiens	55-59
1533430-15	1992	In contrast, 2chloro-ADO inhibits intraglomerular O2- production, which is associated with the complete inhibition of proteinuria in the early phase of anti-Thy1 GN.	Oxygen	50-52	Thy-1 cell surface antigen	Rattus norvegicus	157-161
1325687-8	1992	If glutamate 387 of rat brain sodium channel II is the ion-pairing site for the guanidinium group, then the carbonyl oxygen of asparagine 388 is the hydrogen acceptor for the C-9 and C-10 -OHs.	Oxygen	117-123	complement C9	Rattus norvegicus	175-178
1575729-1	1992	Fractionation by anionic-exchange chromatography of an oxygen-evolving photosystem II complex solubilized with 10 mM dodecyl maltoside shows the existence of a sovra-molecular complex between the internal chlorophyll a antenna CP47 and the chlorophyll a/b minor antenna CP29.	Oxygen	55-61	beaded filament structural protein 2	Homo sapiens	227-231
1373333-8	1992	By Northern blot analysis, Epo messenger RNA levels in Hep3B cells grown in 1% O2 were decreased when concurrently exposed to either IL-1 alpha or TNF-alpha.	Oxygen	79-81	tumor necrosis factor	Homo sapiens	147-156
1348904-5	1992	Infusion of epinephrine (0.1 microM) or angiotensin II (5 nM) increased the rate of O2 uptake nearly exclusively in downstream areas of the lobule where O2 tension was low.	Oxygen	84-86	angiotensinogen	Homo sapiens	40-54
1314664-2	1992	Illumination of a reaction mixture containing protein and cytochrome c in the absence of oxygen brought about reduction of cytochrome c in relation to the duration of light.	Oxygen	89-95	cytochrome c, somatic	Homo sapiens	123-135
1348904-5	1992	Infusion of epinephrine (0.1 microM) or angiotensin II (5 nM) increased the rate of O2 uptake nearly exclusively in downstream areas of the lobule where O2 tension was low.	Oxygen	153-155	angiotensinogen	Homo sapiens	40-54
1525853-0	1992	The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism.	Oxygen	89-95	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	4-8
1312809-4	1992	The oxygen burst induced by FMLP or OZ was inhibited by genistein and alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamid (ST638), which are inhibitors of tyrosine kinase (TK), and was enhanced by 1-(5-isoquinoline-sulfonyl)-3-methyl-piperazine (H-7) and staurosporine, which are inhibitors of protein kinase C (PKC).	Oxygen	4-10	formyl peptide receptor 1	Homo sapiens	28-32
1312801-2	1992	The CCl4 treatment decreased the ADP-stimulated oxygen consumption, respiratory control, and ADP/O values, mainly for substrates oxidation of site I, in isolated mitochondria.	Oxygen	48-54	C-C motif chemokine ligand 4	Rattus norvegicus	4-8
1525853-0	1992	The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism.	Oxygen	89-95	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	10-14
1525853-0	1992	The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism.	Oxygen	89-95	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	15-19
1525853-2	1992	The observed H2O2-sensitivity of par1 mutants has been attributed to an increased sensitivity to reduced oxygen intermediates.	Oxygen	105-111	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	33-37
1525853-3	1992	Accordingly, par1 mutants did not survive an elevated oxygen pressure and were very sensitive to menadione and methylviologene, two chemicals enhancing the deleterious effects of oxygen.	Oxygen	54-60	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	13-17
1525853-3	1992	Accordingly, par1 mutants did not survive an elevated oxygen pressure and were very sensitive to menadione and methylviologene, two chemicals enhancing the deleterious effects of oxygen.	Oxygen	179-185	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	13-17
1525853-4	1992	The specific activities of enzymes involved in oxygen detoxification, such as superoxide dismutase, glucose 6-phosphate dehydrogenase and glutathione reductase, were decreased in par1 mutants and increased after PAR1 over-expression.	Oxygen	47-53	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	179-183
1525853-4	1992	The specific activities of enzymes involved in oxygen detoxification, such as superoxide dismutase, glucose 6-phosphate dehydrogenase and glutathione reductase, were decreased in par1 mutants and increased after PAR1 over-expression.	Oxygen	47-53	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	212-216
1525853-6	1992	These observations indicate that PAR1/YAP1/SNQ3 is involved in the gene regulation of certain oxygen detoxification enzymes.	Oxygen	94-100	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	33-37
1525853-6	1992	These observations indicate that PAR1/YAP1/SNQ3 is involved in the gene regulation of certain oxygen detoxification enzymes.	Oxygen	94-100	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	38-42
1525853-6	1992	These observations indicate that PAR1/YAP1/SNQ3 is involved in the gene regulation of certain oxygen detoxification enzymes.	Oxygen	94-100	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	43-47
1317004-1	1992	The oxidation of NADH and accompanying reduction of oxygen to H2O2 stimulated by polyvanadate was markedly inhibited by SOD and cytochrome c.	Oxygen	52-58	superoxide dismutase 1	Homo sapiens	120-123
1545129-8	1992	The observed increases in DG and in [3H]CDP-DG, in contrast to inositol 1,4,5-trisphosphate and [Ca2+]i responses, correlates well with the ATP gamma S-priming of FMLP-induced O2-formation.	Oxygen	176-178	formyl peptide receptor 1	Homo sapiens	163-167
1545129-1	1992	Although it is evident that the chemotactic peptide FMLP activates O2-formation in neutrophils via the phosphoinositidase-mediated second messenger system, it is less clear how endogenous priming agents such as ATP and platelet activating factor potentiate FMLP action.	Oxygen	67-69	formyl peptide receptor 1	Homo sapiens	52-56
1317004-1	1992	The oxidation of NADH and accompanying reduction of oxygen to H2O2 stimulated by polyvanadate was markedly inhibited by SOD and cytochrome c.	Oxygen	52-58	cytochrome c, somatic	Homo sapiens	128-140
1312347-0	1992	Reaction of ferrous cytochrome c peroxidase with dioxygen: site-directed mutagenesis provides evidence for rapid reduction of dioxygen by intramolecular electron transfer from the compound I radical site.	Oxygen	49-57	cytochrome c, somatic	Homo sapiens	20-32
1312347-0	1992	Reaction of ferrous cytochrome c peroxidase with dioxygen: site-directed mutagenesis provides evidence for rapid reduction of dioxygen by intramolecular electron transfer from the compound I radical site.	Oxygen	126-134	cytochrome c, somatic	Homo sapiens	20-32
1312347-1	1992	The reaction of dioxygen with the ferrous forms of the cloned cytochrome c peroxidase [CCP(MI)] and mutants of CCP(MI) prepared by site-directed mutagenesis was studied by photolysis of the respective ferrous-CO complexes in the presence of dioxygen.	Oxygen	16-24	cytochrome c, somatic	Homo sapiens	62-74
1312347-1	1992	The reaction of dioxygen with the ferrous forms of the cloned cytochrome c peroxidase [CCP(MI)] and mutants of CCP(MI) prepared by site-directed mutagenesis was studied by photolysis of the respective ferrous-CO complexes in the presence of dioxygen.	Oxygen	241-249	cytochrome c, somatic	Homo sapiens	62-74
1311994-1	1992	The effect of endogenously generated reactive oxygen metabolites on the interaction of human blood monocytes with tumour necrosis factor-alpha (TNF-alpha) was investigated.	Oxygen	46-52	tumor necrosis factor	Homo sapiens	144-153
1356323-11	1992	In conclusion, early reperfusion causes a reduction of myocardial tissue damage, but simultaneously, neurohumoral parameters showed a greater activation of the sympathetic nervous system and the renin-angiotensin system apparently causing a deleterious increase in oxygen consumption.	Oxygen	265-271	renin	Sus scrofa	195-200
1422446-2	1992	Overall estimation of the effect of SAS infusion has demonstrated that this drug has a beneficial effect on hemorheology (decreases blood viscosity and vascular resistance, increases coronary blood flow), stabilizes oxygen supply of the myocardium and lowers the extent of its ischemia-induced damage (eliminates ST segment depression).	Oxygen	216-222	tetraspanin 31	Canis lupus familiaris	36-39
1317745-4	1992	Superoxide dismutase (SOD) inhibited the effect of crocidolite, reacting rapidly with .O2- before the secondary release of .OH.	Oxygen	87-89	superoxide dismutase 1	Homo sapiens	0-20
1317745-4	1992	Superoxide dismutase (SOD) inhibited the effect of crocidolite, reacting rapidly with .O2- before the secondary release of .OH.	Oxygen	87-89	superoxide dismutase 1	Homo sapiens	22-25
1537842-13	1992	Interactions at the exocyclic oxygens of cAMP varied between the receptors; cAR2 and cAR3 lacked a stereoselective interaction at the axial oxygen which was present in cAR1.	Oxygen	30-37	carbonic anhydrase 3	Homo sapiens	85-89
1537842-13	1992	Interactions at the exocyclic oxygens of cAMP varied between the receptors; cAR2 and cAR3 lacked a stereoselective interaction at the axial oxygen which was present in cAR1.	Oxygen	30-36	carbonic anhydrase 3	Homo sapiens	85-89
10002133-0	1992	Structural inhomogeneities in oxygen-deficient ErBa2Cu3O6+x associated with the tetragonal-to-orthorhombic transition: Evidence of first-order behavior.	Oxygen	30-36	thyroid hormone receptor beta	Homo sapiens	47-52
1633261-0	1992	D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance.	Oxygen	111-117	growth hormone 1	Homo sapiens	13-27
1633261-0	1992	D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance.	Oxygen	111-117	tumor necrosis factor	Homo sapiens	36-57
1633261-2	1992	In this study, we demonstrated that recombinant human D-factor and growth hormone caused a slight but significant protection of adult rats against oxygen toxicity without affecting levels of pulmonary manganous superoxide dismutase (MnSOD) mRNA.	Oxygen	147-153	growth hormone 1	Homo sapiens	67-81
1633261-3	1992	D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance.	Oxygen	87-93	growth hormone 1	Homo sapiens	13-27
1633261-3	1992	D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance.	Oxygen	87-93	tumor necrosis factor	Homo sapiens	51-72
1633261-3	1992	D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance.	Oxygen	87-93	tumor necrosis factor	Homo sapiens	74-77
1547365-6	1992	It is found that the tissue PO2 at the lethal corner decreases with the decrease in blood velocity, arterial PO2, hemoglobin concentration, P50, and increase in COHb concentration or metabolic rate, while the difference between end-capillary PO2 and venous PO2 increases, which reflects the effect of nonequilibrium kinetics on the delivery of O2 to tissue.	Oxygen	29-31	nuclear factor kappa B subunit 1	Homo sapiens	140-143
1317072-5	1992	A qualitatively similar, but smaller O2(-)-generation response occurred when either opsonized zymosan or recombinant human C5a was used as the PMN stimulus.	Oxygen	37-39	complement C5a receptor 1	Homo sapiens	123-126
1310693-5	1992	Treatment of DMSO-differentiated HL-60 cells with compactin produced a concentration-dependent inhibition of O2- formation in response to FMLP or phorbol myristate acetate.	Oxygen	109-111	formyl peptide receptor 1	Homo sapiens	138-142
1310612-4	1992	The oxygen- and superoxide-dependent effects on methanol dehydrogenase were not observed when either Wurster"s Blue or cytochrome c-55li was used as an electron acceptor.	Oxygen	4-10	cytochrome c, somatic	Homo sapiens	119-131
1310457-4	1992	Evidence that 50 percent O2 produced oxidative stress in the lung included recovery of fluorescent products of lipid peroxidation and partial oxidation of alpha 1-antitrypsin in BAL fluid obtained after O2 exposure.	Oxygen	25-27	serpin family A member 1	Homo sapiens	155-174
1537350-5	1992	In vitro incubation of neutrophils with recombinant human interferon-gamma (rIFN-gamma) showed an increase in oxygen consumption, but no effect on the expression of the LeuCAMs, or the beta chain mRNA.	Oxygen	110-116	interferon gamma	Homo sapiens	58-74
1311742-2	1992	Erythropoietin levels in the medium and cell extracts of low-density Hep3B cells after 20-hour incubation under hypoxic conditions (1% O2) were 25.33 +/- 1.50 mU/ml/10(7) cells and 3.60 +/- 0.50 mU/10(7) cells, respectively.	Oxygen	135-137	erythropoietin	Homo sapiens	0-14
1376641-4	1992	I on formyl Met-Leu-Phe (FMLP)-induced O2(-)-generation of polymorphonuclear leukocytes (PMNs) and platelet aggregation.	Oxygen	39-41	formyl peptide receptor 1	Homo sapiens	25-29
1321161-1	1992	This study evaluated the effect of L-1-oleoyl-2-acetyl-sn-3-glycerol (OAG) on ouabain-sensitive Na,K-dependent oxygen consumption (Na,K-QO2) in intact renal proximal tubule cells (RPTC).	Oxygen	111-117	L1 cell adhesion molecule	Homo sapiens	35-38
1346398-5	1992	However, mAbs against LFA-1 or gp150/95 triggered both H2O2 and O2- release from neutrophils.	Oxygen	57-59	integrin subunit beta 2	Homo sapiens	22-27
1549019-3	1992	Results indicated the standard error of estimate for the predicted oxygen values ranged from 0.11 to 0.22 l.min-1, with correlations between the actual and predicted values ranging from r = 0.22 to r = 0.50.	Oxygen	67-73	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
1549019-5	1992	The actual oxygen cost was underestimated from 0.16 to 0.29 l.min-1 (P less than 0.05) by the equation at each workload.	Oxygen	11-17	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
1730736-3	1992	We have determined that ERG11 message levels increase during growth on glucose, in the presence of heme, and during oxygen limiting growth conditions and, unexpectedly, during anaerobic growth.	Oxygen	116-122	sterol 14-demethylase	Saccharomyces cerevisiae S288C	24-29
1552891-1	1992	In in-vitro study, human immunoglobulin (Ig) denatured by O2 bubbling markedly produced C4a, C3a, and C5a, whereas human albumin treated identically did not.	Oxygen	58-60	complement C5a receptor 1	Homo sapiens	102-105
1730736-7	1992	Sequences resembling ERG11 UAS2 were identified in seven additional oxygen-regulated genes.	Oxygen	68-74	sterol 14-demethylase	Saccharomyces cerevisiae S288C	21-26
1309738-10	1992	These results are discussed in terms of possible mechanisms of communication between the cytochrome c binding site, cytochrome a, and the oxygen binding site within the cytochrome c oxidase molecule.	Oxygen	138-144	cytochrome c, somatic	Homo sapiens	169-181
1736888-3	1992	Vasopressin induces a sharp, transient, pulse of increased bile flow and increased bile calcium within 1 min of infusion, concomitant with rapid changes in perfusate Ca2+ fluxes, glucose output and oxygen uptake.	Oxygen	198-204	arginine vasopressin	Rattus norvegicus	0-11
1370470-0	1992	Reaction of Co(II)bleomycin with dioxygen.	Oxygen	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
1370470-1	1992	The reaction of Co(II)bleomycin with dioxygen has been investigated.	Oxygen	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
1370470-2	1992	Dioxygen binds to the Co(II) complex within the time of mixing according to electron spin resonance and uv-visible spectroscopy and dioxygen analysis.	Oxygen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
1370470-2	1992	Dioxygen binds to the Co(II) complex within the time of mixing according to electron spin resonance and uv-visible spectroscopy and dioxygen analysis.	Oxygen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
1370470-10	1992	In contrast, hydrogen peroxide is readily detected during the reaction of Co(II)Blm with O2.	Oxygen	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
1574962-1	1992	Erythropoietin (EPO) adjusts the red cell mass to the optimal size in order to satisfy the oxygen requirement of the body.	Oxygen	91-97	erythropoietin	Homo sapiens	0-14
1574962-1	1992	Erythropoietin (EPO) adjusts the red cell mass to the optimal size in order to satisfy the oxygen requirement of the body.	Oxygen	91-97	erythropoietin	Homo sapiens	16-19
1574962-2	1992	The amount of circulating EPO is regulated by oxygen sensors in the kidney, which control the secretion of EPO through feedback signals.	Oxygen	46-52	erythropoietin	Homo sapiens	26-29
1574962-2	1992	The amount of circulating EPO is regulated by oxygen sensors in the kidney, which control the secretion of EPO through feedback signals.	Oxygen	46-52	erythropoietin	Homo sapiens	107-110
1288087-2	1992	The contribution of oxygen diffusion to the measured P50 value in resting cells is small.	Oxygen	20-26	nuclear factor kappa B subunit 1	Homo sapiens	53-56
1364279-6	1992	It was found that SASP and its metabolites, such as 5-amino-salicylic acid (5-ASA), and acetyl-5-amino-salicylic acid (AC-5-ASA), but not sulfapyridine (SP) and acetyl-sulfapyridine (Ac-SP) have a direct O2- and .OH scavenging activity in vitro systems.	Oxygen	204-206	aspartic peptidase retroviral like 1	Homo sapiens	18-22
1364279-8	1992	It was concluded that the in vivo antiinflammatory effects of SASP and its metabolites are, at least partly, due to the direct oxygen-centered scavenging activity of these drugs.	Oxygen	127-133	aspartic peptidase retroviral like 1	Homo sapiens	62-66
1364279-4	1992	To scavenge oxygen-centered radicals in vivo, however, SASP and its metabolites have to react with O2- and/or .OH in vitro very rapidly, furthermore they have to reach an appropriate (possible millimolar) concentration range at the site of inflammation.	Oxygen	12-18	aspartic peptidase retroviral like 1	Homo sapiens	55-59
1364279-4	1992	To scavenge oxygen-centered radicals in vivo, however, SASP and its metabolites have to react with O2- and/or .OH in vitro very rapidly, furthermore they have to reach an appropriate (possible millimolar) concentration range at the site of inflammation.	Oxygen	99-101	aspartic peptidase retroviral like 1	Homo sapiens	55-59
1364279-5	1992	To test this possibility, we investigated the direct O2- and .OH scavenging activity of SASP and its metabolites using the specific electron paramagnetic resonance/spin trapping method, and we compared the 50% inhibition rates of SASP and its metabolites with their known concentrations in the bowel and in the human plasma.	Oxygen	53-55	aspartic peptidase retroviral like 1	Homo sapiens	88-92
1489006-6	1992	This was probably due to the increase in tissue oxygen delivery, as there was an increase in the median arterial oxygen content from 79 (65-85) to 150 ml O2 (144-157) following erythropoietin treatment.	Oxygen	48-54	erythropoietin	Homo sapiens	177-191
1489006-6	1992	This was probably due to the increase in tissue oxygen delivery, as there was an increase in the median arterial oxygen content from 79 (65-85) to 150 ml O2 (144-157) following erythropoietin treatment.	Oxygen	113-119	erythropoietin	Homo sapiens	177-191
1489006-6	1992	This was probably due to the increase in tissue oxygen delivery, as there was an increase in the median arterial oxygen content from 79 (65-85) to 150 ml O2 (144-157) following erythropoietin treatment.	Oxygen	154-156	erythropoietin	Homo sapiens	177-191
1510386-3	1992	High levels of CuZn superoxide dismutase mRNA have been observed in the substantia nigra, suggesting that high levels of oxygen free radicals are indeed produced in the structure.	Oxygen	121-127	superoxide dismutase 1	Homo sapiens	15-40
1536404-6	1992	A 90% response to square wave changes of gas composition was maintained up to 60 breaths.min-1 for CO2, O2, and N2O and up to 40 breaths.min-1 for the vapours when the nafion sampling tube was used.	Oxygen	100-102	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
1728289-2	1992	We found that a 3-day exposure to 95% O2 caused (1) an increase in CuZnSOD mRNA (by 41%), CAT mRNA (by 26%), and GP mRNA (by 173%); (2) an increase in CuZnSOD activity (by 30%), a decrease in CAT activity (by 37%), and an increase in GP activity (by 60%); and (3) an increase in CuZnSOD immunodetectable protein (by 26%) and a loss in CAT immunoreactive protein (by 27%).	Oxygen	38-40	catalase	Homo sapiens	90-93
1728289-2	1992	We found that a 3-day exposure to 95% O2 caused (1) an increase in CuZnSOD mRNA (by 41%), CAT mRNA (by 26%), and GP mRNA (by 173%); (2) an increase in CuZnSOD activity (by 30%), a decrease in CAT activity (by 37%), and an increase in GP activity (by 60%); and (3) an increase in CuZnSOD immunodetectable protein (by 26%) and a loss in CAT immunoreactive protein (by 27%).	Oxygen	38-40	catalase	Homo sapiens	192-195
1728289-2	1992	We found that a 3-day exposure to 95% O2 caused (1) an increase in CuZnSOD mRNA (by 41%), CAT mRNA (by 26%), and GP mRNA (by 173%); (2) an increase in CuZnSOD activity (by 30%), a decrease in CAT activity (by 37%), and an increase in GP activity (by 60%); and (3) an increase in CuZnSOD immunodetectable protein (by 26%) and a loss in CAT immunoreactive protein (by 27%).	Oxygen	38-40	catalase	Homo sapiens	192-195
1728289-3	1992	After a 5-day exposure to 95% O2, there was (1) a 93% increase in CuZnSOD mRNA, a 71% increase in CAT mRNA, and a 127% increase in GP mRNA; (2) a 56% increase in CuZnSOD activity, a 70% decrease in CAT activity, and an 89% increase in GP activity; and (3) a 35% increase in CuZnSOD immunoreactive protein and a 55% loss in CAT immunoreactive protein.	Oxygen	30-32	catalase	Homo sapiens	98-101
1728289-3	1992	After a 5-day exposure to 95% O2, there was (1) a 93% increase in CuZnSOD mRNA, a 71% increase in CAT mRNA, and a 127% increase in GP mRNA; (2) a 56% increase in CuZnSOD activity, a 70% decrease in CAT activity, and an 89% increase in GP activity; and (3) a 35% increase in CuZnSOD immunoreactive protein and a 55% loss in CAT immunoreactive protein.	Oxygen	30-32	catalase	Homo sapiens	198-201
1728289-3	1992	After a 5-day exposure to 95% O2, there was (1) a 93% increase in CuZnSOD mRNA, a 71% increase in CAT mRNA, and a 127% increase in GP mRNA; (2) a 56% increase in CuZnSOD activity, a 70% decrease in CAT activity, and an 89% increase in GP activity; and (3) a 35% increase in CuZnSOD immunoreactive protein and a 55% loss in CAT immunoreactive protein.	Oxygen	30-32	catalase	Homo sapiens	198-201
1284690-2	1992	We observed a good correlation between 2,3-BPG and p50 (i.e. the oxygen tension, at which hemoglobin is half-saturated with oxygen).	Oxygen	65-71	nuclear factor kappa B subunit 1	Homo sapiens	51-54
1284690-2	1992	We observed a good correlation between 2,3-BPG and p50 (i.e. the oxygen tension, at which hemoglobin is half-saturated with oxygen).	Oxygen	124-130	nuclear factor kappa B subunit 1	Homo sapiens	51-54
1342232-5	1992	For both purified Hb and whole blood samples, incubation with papaverine, dipyridamole and nifedipine modified P50 (PO2 for half saturation of the Hb/oxygen sites) at pH 7.4: 30.9 mmHg for 0.72 mM papaverine vs 23.9 mmHg for control; 23.9 mmHg for 1.43 mM dipyridamole vs 20.8 mmHg for control; 1.09 mmHg for 2.73 mM nifedipine vs 1.14 mmHg for control stripped Hb.	Oxygen	150-156	nuclear factor kappa B subunit 1	Homo sapiens	111-114
1592171-0	1992	Formulation and stability of freeze-dried proteins: effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone.	Oxygen	76-82	growth hormone 1	Homo sapiens	138-152
1493580-2	1992	Under normal conditions small quantities of oxygen free radicals are produced but they are quenched by intracellular free radical scavenging enzymes (superoxide dismutase, catalase and glutathione peroxidase) or alpha-tocopherol.	Oxygen	44-50	catalase	Homo sapiens	172-180
1316186-1	1992	The electron paramagnetic resonance (EPR) spin trapping technique was used to study the generation of oxygen free radicals from the reaction of hydrogen peroxide with various Co(II) complexes in pH 7.4 phosphate buffer.	Oxygen	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	Oxygen	59-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1396639-5	1992	The maximal oxygen uptake (VO2max; ml.kg-1.min-1) decreased with growth in the untrained group but remained almost constant in the training group.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
1317327-4	1992	Exposure of bovine serum albumin (BSA) (0.5 mg/mL) to pMC540 (0.2 mg/mL-1 mg/mL) results in loss of tryptophan fluorescence and 345 nm emission, suggesting a probable role of either hydroxyl (.OH) or .OH + superoxide (O2-).	Oxygen	218-220	albumin	Homo sapiens	19-32
1563648-2	1992	Increased generation of oxygen- and ethanol-derived free radicals has been observed at the microsomal level, especially through the intervention of the ethanol-inducible cytochrome P450 isoform (CYP2E1).	Oxygen	24-30	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	195-201
1592227-2	1992	Angiotensin II (5 nM) increased perfusion pressure, O2 uptake and the release of lactate, uracil and uric acid from the perfused rat hindlimb.	Oxygen	52-54	angiotensinogen	Rattus norvegicus	0-14
1592227-11	1992	Nitroprusside (0.5 mM) when added during angiotensin II (5 nM) infusion blocked pressure and O2 uptake.	Oxygen	93-95	angiotensinogen	Rattus norvegicus	41-55
1568867-9	1992	These results suggest that reactive oxygen intermediates such as superoxide anion may play an important role in the development of hypersensitivity granulomas and that rh-SOD is capable of inhibiting the lesions by its antioxidant action.	Oxygen	36-42	superoxide dismutase 1	Homo sapiens	171-174
1730547-2	1992	This clinical observation in combination with experimental observations that correlate the induction of superoxide dismutase (SOD) activity with differentiation led to the hypothesis that the basis for the relative vulnerability to oxygen lies in the relative "undifferentiated" nature of proliferating endothelial cells (EC).	Oxygen	232-238	superoxide dismutase 1	Homo sapiens	104-124
1730547-2	1992	This clinical observation in combination with experimental observations that correlate the induction of superoxide dismutase (SOD) activity with differentiation led to the hypothesis that the basis for the relative vulnerability to oxygen lies in the relative "undifferentiated" nature of proliferating endothelial cells (EC).	Oxygen	232-238	superoxide dismutase 1	Homo sapiens	126-129
1317325-9	1992	This latter oxidation of cytochrome c is mediated by active species generated in the reaction between V(IV):desferrioxamine and oxygen, because none of these reagents alone can induce oxidation at a comparable rate.	Oxygen	128-134	cytochrome c, somatic	Homo sapiens	25-37
1352762-4	1992	The results suggest that increases in glutamate, perhaps due to the decreased activities of glutamine synthetase, are correlated with increased oxygen free radical formation during an ischemia/reperfusion insult to the heart.	Oxygen	144-150	glutamate-ammonia ligase	Homo sapiens	92-112
1305556-4	1992	The erythropoietin production depends on the content of oxygen in blood.	Oxygen	56-62	erythropoietin	Homo sapiens	4-18
1550865-8	1992	Induction of TNF can occur through a variety of stimuli, including LPS, TPA, cytokines, calcium flux, and oxygen free-radical mechanisms.	Oxygen	106-112	tumor necrosis factor	Homo sapiens	13-16
1483057-2	1992	Moreover, while exerting chemotactic activity on monocytes and inducing expression of interleukin-1 and interleukin-6 by these cells, TGF beta interferes with bacterially induced tumor necrosis factor alpha production, oxygen radical formation and the adhesiveness of granulocytes to endothelial cells.	Oxygen	219-225	transforming growth factor beta 1	Homo sapiens	134-142
1735668-6	1992	Oxygen diffusion distances (in planar geometry) measured for cubes prepared from SCCVII, RIF-1, Lewis lung or WiDr tumors were 107, 123, 153 and 193 microns, respectively.	Oxygen	0-6	replication timing regulatory factor 1	Mus musculus	89-94
15278583-10	1992	Hill equation was used for oxygen dissociation curve with n of 2.7 and P50 of 27.0 mmHg.	Oxygen	27-33	nuclear factor kappa B subunit 1	Homo sapiens	71-74
15278583-15	1992	Under conditions studied, a decrease in P50 reduced oxygen utilization faster than that in any other parameters.	Oxygen	52-58	nuclear factor kappa B subunit 1	Homo sapiens	40-43
1396639-6	1992	The oxygen cost of running at 15 km.h-1 (VO2 15, ml.kg-1.min-1) was persistently lower in the trained group but decreased similarly with age in both groups.	Oxygen	4-10	CD59 molecule (CD59 blood group)	Homo sapiens	57-62
1396639-12	1992	In conclusion, recent and the present findings would suggest that changes in the oxygen cost of running and VO2max (ml.kg-1.min-1) during growth may mainly be due to an overestimation of the body mass dependency of VO2 during running.	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	124-129
1728718-2	1992	In vitro immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a, but albumin identically treated did not.	Oxygen	47-53	complement C5a receptor 1	Homo sapiens	86-89
1311041-9	1992	The toxic oxygen species produced by this system caused lysis of the epithelial targets which was dependent on the duration of incubation and the concentrations of MPO and GO.	Oxygen	10-16	myeloperoxidase	Homo sapiens	164-167
1311041-13	1992	Furthermore, PMN MPO is capable of generating toxic oxygen species which can lyse these epithelial cells.	Oxygen	52-58	myeloperoxidase	Homo sapiens	17-20
1290975-0	1992	[Increased activity of erythrocyte superoxide dismutase as the result of adaptation to long-term oxygen therapy].	Oxygen	97-103	superoxide dismutase 1	Homo sapiens	35-55
1542209-13	1992	PAM with TNF-alpha pretreatment, and PAM with IFN-gamma pretreatment could release increased amount of O2- significantly, compared with control.	Oxygen	103-105	interferon gamma	Homo sapiens	46-55
1290975-4	1992	The authors have found the increase of SOD activity in the treated patients which can be interpreted as a generalized adaptation of the organism to long term oxygen therapy.	Oxygen	158-164	superoxide dismutase 1	Homo sapiens	39-42
1394906-1	1992	Oxidative phosphorylation of liver mitochondria in Oncomelania snail was separately detected by using oxygen electrode and spectrophotometer.	Oxygen	102-108	snail family transcriptional repressor 1	Homo sapiens	63-68
1762062-6	1991	Although oxygen exposure per se decreased the total level of lung cytochrome P-450, poly I: poly C per se induced a deeper decrease to levels similar in air- or oxygen-exposed rats.	Oxygen	9-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-90
1662497-3	1991	This hypothesis was tested in an in vitro system by analyzing the effect of authentic NO (dilutions of a saturated aqueous solution) on .O2- production (detected spectrophotometrically as reduction of cytochrome c) by fMet-Leu-Phe-activated human leukocytes (PMN).	Oxygen	137-139	cytochrome c, somatic	Homo sapiens	201-213
1744095-5	1991	Hydrogen bonding occurs between Arg151 and the ring oxygen and 4-hydroxyl of the sugar ligand, two backbone carbonyls, and a side chain in ABP, and similar interactions in the lac repressor would be anticipated.	Oxygen	52-58	sex hormone binding globulin	Homo sapiens	139-142
1958377-2	1991	Acute exposure to 100% O2 results in severe decreases in respiratory function and is accompanied by alterations in pulmonary surfactant metabolism, including the regulation of surfactant proteins A, B, and C (SP-A, SP-B, SP-C).	Oxygen	23-25	surfactant protein C	Homo sapiens	221-225
1665488-5	1991	These results suggest that SOD-Fc conjugates, which have long half-lives, effectively perform dismutation of superoxide radicals and may be useful for preventing tissue injury caused by hazardous oxygen metabolites.	Oxygen	196-202	superoxide dismutase 1	Homo sapiens	27-30
1658233-6	1991	Ranakinin was equipotent with substance P and [Sar9,Met(O2)11]substance P in inhibiting the binding of 125I-Bolton-Hunter-[Sar9,Met(O2)11]substance P, a selective radioligand for the NK1 receptor, to binding sites in rat submandibular gland membranes (IC50 1.6 +/- 0.3 nM; n = 5).	Oxygen	56-58	tachykinin precursor 1	Homo sapiens	62-73
1658233-6	1991	Ranakinin was equipotent with substance P and [Sar9,Met(O2)11]substance P in inhibiting the binding of 125I-Bolton-Hunter-[Sar9,Met(O2)11]substance P, a selective radioligand for the NK1 receptor, to binding sites in rat submandibular gland membranes (IC50 1.6 +/- 0.3 nM; n = 5).	Oxygen	56-58	tachykinin precursor 1	Homo sapiens	62-73
1960995-2	1991	Tumor necrosis factor, however, has been shown to impart increased resistance in vitro and in vivo against reactive oxygen species stress, including radiation therapy and oxygen toxicity, possibly because of the induction of increased cellular buffering capacities.	Oxygen	116-122	tumor necrosis factor	Homo sapiens	0-21
1721054-2	1991	We have determined the source of the oxygen in both NO and in citrulline formed by the constitutive NO synthase from the vascular endothelium and brain and by the inducible NO synthase from the murine macrophage cell line J774.	Oxygen	37-43	nitric oxide synthase 2, inducible	Mus musculus	163-184
1660479-6	1991	These results indicate that: 1) .OH radical was most likely the ultimate O2 species responsible for DNA damage and activation of poly(ADP)ribose polymerase; 2) both H2O2 and .OH radicals were involved in the other cytotoxic effects (inhibition of protein synthesis and reduction of NAD and ATP stores); and 3) NAD and ATP depletion did not result solely from activation of poly(ADP)ribose polymerase, but other mechanisms are likely to be involved.	Oxygen	73-75	poly(ADP-ribose) polymerase 1	Homo sapiens	129-155
1660479-6	1991	These results indicate that: 1) .OH radical was most likely the ultimate O2 species responsible for DNA damage and activation of poly(ADP)ribose polymerase; 2) both H2O2 and .OH radicals were involved in the other cytotoxic effects (inhibition of protein synthesis and reduction of NAD and ATP stores); and 3) NAD and ATP depletion did not result solely from activation of poly(ADP)ribose polymerase, but other mechanisms are likely to be involved.	Oxygen	73-75	poly(ADP-ribose) polymerase 1	Homo sapiens	373-399
1744584-3	1991	At 10 U/ml, IL-10 markedly suppressed m phi release of reactive oxygen intermediates (ROI) (IC50 3.7 +/- 1.8 U/ml), but only weakly inhibited m phi release of reactive nitrogen intermediates (RNI).	Oxygen	64-70	interleukin 10	Mus musculus	12-17
1726709-4	1991	In addition, IL-8 was found to be a potent priming agent and to enhance O2- release stimulated by FMLP.	Oxygen	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
1726709-1	1991	Interleukin-8 (IL-8) stimulated an increase in cytoplasmic-free Ca2+ ([Ca2+]i) and intracellular pH (pHi) in parallel at low concentrations (0.5 to 5 ng/mL), and stimulated O2- release and membrane depolarization in parallel at high concentrations (50 to 5,000 ng/mL).	Oxygen	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1726709-4	1991	In addition, IL-8 was found to be a potent priming agent and to enhance O2- release stimulated by FMLP.	Oxygen	72-74	formyl peptide receptor 1	Homo sapiens	98-102
1726709-1	1991	Interleukin-8 (IL-8) stimulated an increase in cytoplasmic-free Ca2+ ([Ca2+]i) and intracellular pH (pHi) in parallel at low concentrations (0.5 to 5 ng/mL), and stimulated O2- release and membrane depolarization in parallel at high concentrations (50 to 5,000 ng/mL).	Oxygen	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
1657156-4	1991	Reaction of EH2 with oxygen is 1.7-fold faster (k = 4480 min-1) than aerobic turnover and 13-fold faster than the anaerobic conversion of EH2 to EH4.	Oxygen	21-27	epoxide hydrolase 4	Homo sapiens	145-148
1667247-5	1991	The intermediacy of active oxygen species in CF formation is suggested by the anticlastogenic effect of antioxidant enzymes such as superoxide dismutase and catalase.	Oxygen	27-33	catalase	Rattus norvegicus	157-165
1836354-4	1991	The autoxidation of glyceraldehyde in imidazole-glycylglycine buffer, measured by oxygen consumption, depends on the buffer concentration and decreases in the presence of superoxide dismutase and catalase.	Oxygen	82-88	catalase	Homo sapiens	196-204
1663174-3	1991	SOD inhibited the effect of crocidolite, because SOD reacted with .O2- released by stimulation with crocidolite and inhibited the subsequent development of .OH.	Oxygen	67-69	superoxide dismutase 1	Homo sapiens	0-3
1667720-8	1991	NAD(P)H--cytochrome c reductase enzyme, which catalyzes superoxide anion production, is present in platelets at high specific activity, as well as those enzymes who protect the cells from oxygen reactive species.	Oxygen	188-194	cytochrome c, somatic	Homo sapiens	9-21
1766349-3	1991	Oxygen uptake (VO2) responses were significantly more pronounced in direct relationship to the bench height: B-12 greater than B-10 greater than B-8 greater than B-6 (P less than 0.05).	Oxygen	0-6	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	109-113
1953747-4	1991	The inhibition of thioltransferase at high drug concentrations in the presence of oxygen was associated with cross-linking of monomers into dimers within 5 min and, in the case of cis-platin treatment, to trimers in 20 min incubation.	Oxygen	82-88	glutaredoxin-1	Sus scrofa	18-34
1656733-2	1991	A negative feedback system, in which tissue oxygenation controls Epo production and Epo controls red blood cell (RBC) production, provides homeostasis in oxygen delivery to body tissues.	Oxygen	44-50	erythropoietin	Homo sapiens	65-68
1928074-7	1991	Epo secretion is stimulated by hypoxia, which is detected by an oxygen sensor located in the kidney.	Oxygen	64-70	erythropoietin	Homo sapiens	0-3
1928771-2	1991	The transcutaneous index (TCI = PtcO2/arterial oxygen tension [PaO2]) is known to depend both on age and on cardiac index but is assumed to be independent of other physiologic variables.	Oxygen	47-53	latexin	Homo sapiens	26-29
1663174-3	1991	SOD inhibited the effect of crocidolite, because SOD reacted with .O2- released by stimulation with crocidolite and inhibited the subsequent development of .OH.	Oxygen	67-69	superoxide dismutase 1	Homo sapiens	49-52
1777846-2	1991	injection of human recombinant interleukin-6 (IL-6; 20-100 ng) caused significant increases in colonic temperature and resting oxygen consumption (VO2) in conscious rats.	Oxygen	127-133	interleukin 6	Homo sapiens	31-44
1777846-2	1991	injection of human recombinant interleukin-6 (IL-6; 20-100 ng) caused significant increases in colonic temperature and resting oxygen consumption (VO2) in conscious rats.	Oxygen	127-133	interleukin 6	Homo sapiens	46-50
1940433-1	1991	In this report, we have investigated the secretion and synthesis of transforming growth factor-beta 1 (TGF-beta 1) by human dermal fibroblast cultures in response to hypoxia (2% oxygen), and have compared it to standard oxygen culture conditions (15% oxygen at the cell surface).	Oxygen	178-184	transforming growth factor beta 1	Homo sapiens	68-101
1940433-2	1991	Sandwich enzyme-linked immunosorbent assay (SELISA) showed a selective and progressive increase in secretion of the TGF-beta 1 isoform in response to hypoxia, up to ninefold after cultures were exposed to low oxygen for 72 h; TGF-beta 2 peptide levels were not increased.	Oxygen	209-215	transforming growth factor beta 1	Homo sapiens	116-126
1940433-3	1991	We then investigated the transcriptional regulation of the TGF-beta 1 gene in response to low and standard oxygen tensions.	Oxygen	107-113	transforming growth factor beta 1	Homo sapiens	59-69
1940433-4	1991	In the first 24-48 h, TGF-beta 1 mRNA levels decreased steadily in both oxygen environments.	Oxygen	72-78	transforming growth factor beta 1	Homo sapiens	22-32
1940433-6	1991	At 72 h, steady-state TGF-beta 1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-beta 1 m-RNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-beta 1 transcription rather than mRNA stability.	Oxygen	94-100	transforming growth factor beta 1	Homo sapiens	22-32
1940433-6	1991	At 72 h, steady-state TGF-beta 1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-beta 1 m-RNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-beta 1 transcription rather than mRNA stability.	Oxygen	187-193	transforming growth factor beta 1	Homo sapiens	221-231
1940433-6	1991	At 72 h, steady-state TGF-beta 1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-beta 1 m-RNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-beta 1 transcription rather than mRNA stability.	Oxygen	187-193	transforming growth factor beta 1	Homo sapiens	221-231
1940433-6	1991	At 72 h, steady-state TGF-beta 1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-beta 1 m-RNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-beta 1 transcription rather than mRNA stability.	Oxygen	187-193	transforming growth factor beta 1	Homo sapiens	221-231
1940433-6	1991	At 72 h, steady-state TGF-beta 1 mRNA levels were 8 times greater in low compared to standard oxygen, and this increase was reversible upon re-exposure of fibroblast cultures to standard oxygen tension for 24 h. Elevated TGF-beta 1 m-RNA levels in both low and standard oxygen declined steadily and with the same half-life after the addition of actinomycin D, suggesting that hypoxia increased TGF-beta 1 transcription rather than mRNA stability.	Oxygen	187-193	transforming growth factor beta 1	Homo sapiens	221-231
1940433-7	1991	We conclude that low oxygen tension upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts, and leads to increased secretion of this peptide.	Oxygen	21-27	transforming growth factor beta 1	Homo sapiens	65-75
1756840-3	1991	Oxygen-induced lung injury may result from an overproduction of oxygen metabolites normally scavenged by antioxidants such as superoxide dismutase (SOD), glutathione peroxidase, catalase and reduced glutathione (GSH).	Oxygen	0-6	catalase	Rattus norvegicus	178-186
1756840-3	1991	Oxygen-induced lung injury may result from an overproduction of oxygen metabolites normally scavenged by antioxidants such as superoxide dismutase (SOD), glutathione peroxidase, catalase and reduced glutathione (GSH).	Oxygen	64-70	catalase	Rattus norvegicus	178-186
1940433-1	1991	In this report, we have investigated the secretion and synthesis of transforming growth factor-beta 1 (TGF-beta 1) by human dermal fibroblast cultures in response to hypoxia (2% oxygen), and have compared it to standard oxygen culture conditions (15% oxygen at the cell surface).	Oxygen	178-184	transforming growth factor beta 1	Homo sapiens	103-113
1836828-4	1991	Maximal oxygen uptake (VO2max) for the male population was 2.23 l.min-1 (32.9 ml.kg-1.min-1).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	66-71
1812295-3	1991	KF-14363 significantly inhibited active oxygen production in peritoneal exudate cells (PEEC) stimulated with arachidonic acid, A23187 and carbon tetrachloride (CCl4) at concentrations over 10 microM, 100 microM and 1 microM, respectively.	Oxygen	40-46	C-C motif chemokine ligand 4	Rattus norvegicus	160-164
1812295-5	1991	Superoxide dismutase (SOD, 10(4) U/ml) significantly inhibited CCl4-stimulated production of active oxygen in PEEC.	Oxygen	100-106	C-C motif chemokine ligand 4	Rattus norvegicus	63-67
1836828-4	1991	Maximal oxygen uptake (VO2max) for the male population was 2.23 l.min-1 (32.9 ml.kg-1.min-1).	Oxygen	8-14	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
1928216-3	1991	Recent electron paramagnetic resonance (EPR) spectroscopy studies show a burst of oxygen-centered free radical generation during the first 60 seconds of reflow and administration of either a free radical scavenger, such as superoxide dismutase (SOD), or an iron chelator, such as deferoxamine, prevents this burst.	Oxygen	82-88	superoxide dismutase 1	Homo sapiens	223-243
1924315-1	1991	Copper, zinc superoxide dismutase (SOD1 gene product) (superoxide:superoxide oxidoreductase, EC 1.15.1.1) is a copper-containing enzyme that functions to prevent oxygen toxicity.	Oxygen	162-168	oxidoreductase	Saccharomyces cerevisiae S288C	77-91
1654081-4	1991	In the absence of O2, inactivation of 1 mol of L-1 occurs after the oxidation of 34 mol of phenidone and the covalent binding of 0.8 mol of phenidone-derived metabolite(s) to L-1.	Oxygen	18-20	seed linoleate 13S-lipoxygenase-1	Glycine max	47-50
1654081-5	1991	In the presence of O2, inactivation of 1 mol of L-1 occurs already after oxidation of 11 mol of phenidone and only involves the covalent binding of 0.4 mol of phenidone-derived metabolite(s) to L-1.	Oxygen	19-21	seed linoleate 13S-lipoxygenase-1	Glycine max	48-51
1654081-5	1991	In the presence of O2, inactivation of 1 mol of L-1 occurs already after oxidation of 11 mol of phenidone and only involves the covalent binding of 0.4 mol of phenidone-derived metabolite(s) to L-1.	Oxygen	19-21	seed linoleate 13S-lipoxygenase-1	Glycine max	194-197
1654081-6	1991	A mechanism is proposed for L-1 inactivation by phenidone, which involves the irreversible binding of a phenidone metabolite to the protein and the oxidation of an L-1 amino acid residue (in the presence of O2).	Oxygen	207-209	seed linoleate 13S-lipoxygenase-1	Glycine max	28-31
15374429-1	1991	Catalase-mediated oxygen evolution from H(2)O(2) was measured with a Clark electrode in a closed, buffered aqueous medium in a properly designed experimental model.	Oxygen	18-24	catalase	Homo sapiens	0-8
1753679-2	1991	Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis.	Oxygen	0-6	erythropoietin	Homo sapiens	73-76
1753679-7	1991	Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery.	Oxygen	120-126	erythropoietin	Homo sapiens	64-67
1877456-5	1991	Depressed developed pressure and oxygen consumption in the PMA- and angiotensin II-treated hearts may have been due to a decrease in amplitude of effective [Ca2+]i transients, because the [Ca2+]i threshold for cross-bridge interaction was presumably higher than the diastolic [Ca2+]i in these hearts.	Oxygen	33-39	angiotensinogen	Rattus norvegicus	68-82
1820296-9	1991	The intravenous application of nitroprusside and the ACE-inhibitor benazepril decreased both the systolic stress-time integral and the myocardial oxygen consumption in proportion to each other indicating unchanged economy of myocardial contraction.	Oxygen	146-152	angiotensin I converting enzyme	Homo sapiens	53-56
1893513-4	1991	The nitro-reduction of 20 microM [4,5,9,10-3H]1-nitropyrene or 20 microM [4-3H]3-nitrofluoranthene by aldehyde oxidase required the presence of flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD), and was inhibited by oxygen in a concentration-dependent manner.	Oxygen	231-237	aldehyde oxidase 1	Homo sapiens	102-118
1930739-5	1991	In vivo studies of hyperbaric oxygen following administration of CCl4 in a rat model have shown improved survival and decreased hepatotoxicity.	Oxygen	30-36	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
1658674-9	1991	To evaluate a possible direct effect on the pituitary, IL-6 was incubated in vitro with hemipituitaries under an atmosphere of 95% O2/5% CO2.	Oxygen	131-133	interleukin 6	Rattus norvegicus	55-59
1778615-1	1991	Studies on L-asparaginase synthesis in V. proteus showed increased synthesis in cultures grown under conditions of moderate aeration (P less than 0.005) after oxygen had been used up from the medium.	Oxygen	159-165	asparaginase and isoaspartyl peptidase 1	Homo sapiens	11-25
1653877-2	1991	Human polymorphonuclear neutrophils (PMN) respond to ATP with an elevation in intracellular calcium and a marked enhancement of O2-production in response to stimulation by the chemotactic peptide N"-formyl-Met-Leu-Phe (FMLP).	Oxygen	128-130	formyl peptide receptor 1	Homo sapiens	196-217
1715512-9	1991	Superoxide dismutase, catalase and peroxidase, which protect cells against oxygen radical damage, were found in all the cell lines and in rat hepatocytes and S9.	Oxygen	75-81	catalase	Rattus norvegicus	22-30
1868064-0	1991	Reactivity of medium-chain acyl-CoA dehydrogenase toward molecular oxygen.	Oxygen	67-73	acyl-CoA dehydrogenase medium chain	Homo sapiens	14-49
1780295-4	1991	A conclusion has been made that one of the most important mechanisms of the adaptive effect of PRL is its ability to suppress thyroid function, thus decreasing the metabolism level, which results in reduction of oxygen consumption and improves body tolerance to stress.	Oxygen	212-218	prolactin	Rattus norvegicus	95-98
1813269-6	1991	SOD and CAT, the oxygen radical scavengers, can reduce protein catabolism to a certain extent, and protect the hepatic function from being injured.	Oxygen	17-23	catalase	Rattus norvegicus	8-11
1868064-1	1991	The free two-electron-reduced form of medium-chain acyl-CoA dehydrogenase is reoxidized by 120 microM molecular oxygen (50 mM phosphate buffer, pH 7.6, 2 degrees C) with a half-time of approximately 7 s. Reoxidation yields hydrogen peroxide as a major product with only traces of the superoxide anion.	Oxygen	112-118	acyl-CoA dehydrogenase medium chain	Homo sapiens	38-73
1938743-1	1991	We studied the effect of interleukin 1 alpha (IL-1) in the protection against O2 toxicity.	Oxygen	78-80	interleukin 1 alpha	Rattus norvegicus	25-44
1872419-6	1991	Catalase activity was 59.3 +/- 4.9 nmol O2 produced.min-1.mg protein-1 in type II cells, 13.2 +/- 1.8 in macrophages, and 11.4 +/- 2.7 in endothelial cells.	Oxygen	40-42	catalase	Rattus norvegicus	0-8
1910584-11	1991	These results suggested that autoxidation of heme and of ferrous ions to the unusable ferric form largely contribute toward the oxygen sensitivity of the ferrochelatase reaction in vitro.	Oxygen	128-134	ferrochelatase	Rattus norvegicus	154-168
1648528-12	1991	This increase in oxygen consumption was inhibited by the addition of superoxide dismutase and catalase.	Oxygen	17-23	catalase	Rattus norvegicus	94-102
1864964-4	1991	Pretreatment of cells with various concentrations of propranolol enhanced (less than or equal to 200 microM) or inhibited (greater than 300 microM) PLD-induced production of PA (mass and radiolabel) in a manner that correlated with enhancement or inhibition of O2 consumption in PMN stimulated with 1 microM FMLP in the absence of cytochalasin B.	Oxygen	261-263	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	148-151
1651729-1	1991	NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein which catalyzes the two-electron reduction of quinones and azo-dyes and thus prevents the formation of free radicals and toxic oxygen metabolites that may be generated by the one-electron reductions catalyzed by cytochrome P450 reductase.	Oxygen	183-189	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
1893645-3	1991	The benefits of ACE inhibition include not only a reduction in blood pressure but also improved insulin responsiveness, prevention of potassium loss, diminished myocardial oxygen demand, suppression of catecholamines, and interaction with bradykinin and prostaglandins.	Oxygen	172-178	angiotensin I converting enzyme	Homo sapiens	16-19
1938743-7	1991	In rats insufflated with IL-1 that survived exposure to 100% O2 for 7 days, the activities of pulmonary Mn-SOD, Cu,Zn-SOD, catalase, and glutathione peroxidase were all increased.	Oxygen	61-63	superoxide dismutase 1	Rattus norvegicus	112-121
1712813-2	1991	Production of O2- in response to FMLP, TNF, IFN-gamma, platelet activating factor, LPS, substance P, and PMA by human eosinophils in suspension and in contact with polystyrene ELISA plastic (PL) or biologic surfaces was studied.	Oxygen	14-16	formyl peptide receptor 1	Homo sapiens	33-37
1864384-3	1991	Based on the assumption that there is 1 cytochrome b559 per reaction centre it has been found that oxygen-evolving complexes containing CP26 and CP29 bind 42 chlorophyll molecules.	Oxygen	99-105	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	136-140
1956126-7	1991	2) After training, both heart rates and oxygen uptake during submaximal work loads significantly decreased in group H, but only heart rates significantly decreased in group L. 3) Heart rates with a same oxygen-uptake load during submaximal work seemed to increase in group H, but significantly decreased in group L. 4) The mechanical efficiency during the submaximal work load significantly increased in group H, but not in group L. 5) DBP and MBP during the submaximal work load in group L significantly decreased compared with those before the training.	Oxygen	203-209	D-box binding PAR bZIP transcription factor	Homo sapiens	436-439
1712813-2	1991	Production of O2- in response to FMLP, TNF, IFN-gamma, platelet activating factor, LPS, substance P, and PMA by human eosinophils in suspension and in contact with polystyrene ELISA plastic (PL) or biologic surfaces was studied.	Oxygen	14-16	tumor necrosis factor	Homo sapiens	39-42
1712813-2	1991	Production of O2- in response to FMLP, TNF, IFN-gamma, platelet activating factor, LPS, substance P, and PMA by human eosinophils in suspension and in contact with polystyrene ELISA plastic (PL) or biologic surfaces was studied.	Oxygen	14-16	interferon gamma	Homo sapiens	44-53
1712813-2	1991	Production of O2- in response to FMLP, TNF, IFN-gamma, platelet activating factor, LPS, substance P, and PMA by human eosinophils in suspension and in contact with polystyrene ELISA plastic (PL) or biologic surfaces was studied.	Oxygen	14-16	tachykinin precursor 1	Homo sapiens	88-99
1654818-1	1991	Cytochrome c(3+)-catalyzed peroxidation of phosphatidylcholine liposomes by hydrogen peroxide (H2O2) was indicated by the production of thiobarbituric acid reactive substances, oxygen consumption, and emission of spontaneous chemiluminescence.	Oxygen	177-183	cytochrome c, somatic	Homo sapiens	0-12
2064120-2	1991	At 1 month the response to a single breath of oxygen during normoxia was a decrease in minute ventilation of 264 +/- 34.2 (SEM) ml.min-1 during the 10-s period following the stimulus (p less than 0.001).	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
2064120-5	1991	By the age of 3 months, the absolute ventilatory response to a single breath of oxygen increased significantly in normoxia by 118 +/- 35.2 ml.min-1 (p less than 0.01); the test response to breathing 16% oxygen paralleled the response to normoxia and was on average 254 +/- 26.6 ml.min-1 larger than the response when breathing air (p less than 0.001).	Oxygen	80-86	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
2064120-5	1991	By the age of 3 months, the absolute ventilatory response to a single breath of oxygen increased significantly in normoxia by 118 +/- 35.2 ml.min-1 (p less than 0.01); the test response to breathing 16% oxygen paralleled the response to normoxia and was on average 254 +/- 26.6 ml.min-1 larger than the response when breathing air (p less than 0.001).	Oxygen	80-86	CD59 molecule (CD59 blood group)	Homo sapiens	281-286
1751104-7	1991	This study demonstrated that EPO could decrease enhanced PMA-activated reactive oxygen metabolite production and suggested that this decrease may protect against tissue damage, including red blood cell hemolysis in the uremic milieu.	Oxygen	80-86	erythropoietin	Homo sapiens	29-32
1834516-5	1991	Despite a significant decrease in arterial blood oxygen content arteriovenous variation by O2 content at pO2 differential from 100 to 40 mm Hg is within the normal level due to various directions of changes in P50 and Hill"s coefficient of probands" whole blood.	Oxygen	91-93	nuclear factor kappa B subunit 1	Homo sapiens	210-213
1955004-0	1991	S-erythropoietin levels decrease in patients with chronic hypoxia starting domiciliary oxygen therapy.	Oxygen	87-93	erythropoietin	Homo sapiens	2-16
1955004-2	1991	After 24 h of supplementary oxygen treatment there was a fall in the median s-Epo level from 11.3 to 4.4 IU.l-1 (p less than 0.01).	Oxygen	28-34	erythropoietin	Homo sapiens	78-81
1646088-0	1991	Interferon-gamma and immunoglobulin enhance mineral dust-induced production of reactive oxygen metabolites by human macrophages.	Oxygen	88-94	interferon gamma	Homo sapiens	0-16
2066988-1	1991	A novel series of 3-O-alkylascorbic acids (3-RASA, 3a-n) was synthesized to act as radical scavengers for active oxygen species and free radicals, and their redox potentials and inhibitory effects on lipid peroxidation in rat liver microsomes were evaluated.	Oxygen	113-119	RAS p21 protein activator 1	Rattus norvegicus	45-49
1725724-0	1991	In vitro interferon and virus production at in vivo physiologic oxygen tensions.	Oxygen	64-70	interferon alpha 1	Homo sapiens	9-19
1725724-4	1991	Growth for three months at the three different oxygen tensions prior to infection reduced the difference in IFN production at the different oxygen tensions.	Oxygen	47-53	interferon alpha 1	Homo sapiens	108-111
1725724-4	1991	Growth for three months at the three different oxygen tensions prior to infection reduced the difference in IFN production at the different oxygen tensions.	Oxygen	140-146	interferon alpha 1	Homo sapiens	108-111
1955004-6	1991	A significant negative relationship was found between the arterial oxygen tension and the log value for the s-Epo level (r = 0.40, p less than 0.005).	Oxygen	67-73	erythropoietin	Homo sapiens	110-113
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	interferon gamma	Homo sapiens	27-36
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	interferon gamma	Homo sapiens	70-79
1839618-4	1991	After the illumination, addition of 300 unit/ml of catalase to the illuminated HPD-ascorbate solution initiated a return of 20% of the oxygen.	Oxygen	135-141	catalase	Mus musculus	51-59
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	tumor necrosis factor	Homo sapiens	100-103
1742180-2	1991	The erythrocytosis was associated with an abnormally elevated set point of erythropoietin production in which the sensitivity fluctuated independently, but corresponded to the alterations in the oxygen-carrying capacity of the blood, when the hematocrit was lowered by phlebotomies.	Oxygen	195-201	erythropoietin	Homo sapiens	75-89
1795709-2	1991	Scavengers and inhibitors of different activated oxygen species (sodium azide, sodium benzoate, catalase and superoxide dismutase) prevent the formation of breaks in full or partly.	Oxygen	49-55	catalase	Homo sapiens	96-104
1792578-6	1991	The results of the trail revealed the necessity of measuring the maximal oxygen demand the index of functional aerobic capacity, the maximal heart-rate frequency, and the index of chronotropic heart-rate.	Oxygen	73-79	TNF superfamily member 10	Homo sapiens	19-24
2050696-7	1991	It was isolated from purified apoE3 preparations that had undergone oxygen-mediated dimerization and shown to elute from a Sephacryl S-300 column in a position with the expected molecular weight of a homodimer.	Oxygen	68-74	apolipoprotein E	Homo sapiens	30-35
1950255-3	1991	Catalase of bacteria introduced into the medium for study ensures the rapid saturation of the medium with oxygen and the completion of the oxidation of glucose in 10-60 minutes.	Oxygen	106-112	catalase	Homo sapiens	0-8
2050696-7	1991	It was isolated from purified apoE3 preparations that had undergone oxygen-mediated dimerization and shown to elute from a Sephacryl S-300 column in a position with the expected molecular weight of a homodimer.	Oxygen	68-74	superoxide dismutase 1	Homo sapiens	200-209
2059199-5	1991	TSP-treated monocytes exerted enhanced CL to aggregated IgG when compared with untreated or albumin-treated cells, suggesting that TSP up-regulated the cells" capacity to mediate Fc receptor-dependent generation of reactive oxygen.	Oxygen	224-230	thrombospondin 1	Homo sapiens	0-3
2059199-5	1991	TSP-treated monocytes exerted enhanced CL to aggregated IgG when compared with untreated or albumin-treated cells, suggesting that TSP up-regulated the cells" capacity to mediate Fc receptor-dependent generation of reactive oxygen.	Oxygen	224-230	thrombospondin 1	Homo sapiens	131-134
1711785-6	1991	Early postnatal hyperoxia (greater than 95% O2, 72 h) elevated catalase mRNA/mg DNA and doubled its half-life without changing its rate of transcription.	Oxygen	44-46	catalase	Rattus norvegicus	63-71
2040698-2	1991	Upon exposure to hyperoxia (greater than 99% O2, 630 torr) the transgenic CuZnSOD mice showed increased survival, decreased morphologic evidence of lung damage such as edema and hyaline membrane formation, and reduction in the number of lung neutrophils.	Oxygen	45-47	superoxide dismutase 1, soluble	Mus musculus	74-81
1910301-6	1991	When scavengers of oxygen-derived free radicals (superoxide dismutase, catalase, and dimethylsulfoxide) were added to the ethanol-metabolizing system they prevented generation of the activity.	Oxygen	19-25	catalase	Rattus norvegicus	71-79
2042794-6	1991	Finally human CGRP produced a significant increase in the venous partial O2 pressure and in the hematocrit and a significant decrease in the venous partial CO2 pressure.	Oxygen	73-75	calcitonin related polypeptide alpha	Homo sapiens	14-18
24194103-3	1991	The IL-2 dependent DNA synthesis and the activation of cytotoxic T cells are positively regulated by cysteine, while the activity of the transcription factor NFkB and the production of IL-2 are stimulated by active oxygen species and inhibited by cysteine or GSH.	Oxygen	215-221	interleukin 2	Homo sapiens	185-189
1715263-9	1991	The p50 (the pO2 at which haemoglobin is 50% saturated) describes the oxygen-haemoglobin dissociation curve; normally its value is +/- 27 mm Hg.	Oxygen	70-76	nuclear factor kappa B subunit 1	Homo sapiens	4-7
2049402-4	1991	Oxygen consumption by isolated hepatocytes from starved rats was also increased by copper (II) and a partial inhibition due to catalase was observed.	Oxygen	0-6	catalase	Rattus norvegicus	127-135
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Oxygen	86-88	catalase	Rattus norvegicus	374-382
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Oxygen	86-88	catalase	Rattus norvegicus	384-387
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Oxygen	145-151	catalase	Rattus norvegicus	374-382
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Oxygen	145-151	catalase	Rattus norvegicus	384-387
1646160-1	1991	Docosahexaenoic (22:6 n-3) and eicosapentaenoic acid (20:5 n-3) stimulated the oxygen-dependent respiratory burst in intact neutrophils in a dose-dependent manner as measured by either superoxide dismutase (SOD)-inhibitable cytochrome c reduction and lucigenin-dependent chemiluminescence.	Oxygen	79-85	cytochrome c, somatic	Homo sapiens	224-236
1654786-0	1991	Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance.	Oxygen	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	84-111
1864487-3	1991	The enzyme inducer citiolone and the free oxygen radical scavenging enzymes superoxide dismutase, catalase and glutathione peroxidase protected against the disturbed growth and development of the embryos at 50 mmol/l glucose when added to the culture media.	Oxygen	42-48	catalase	Rattus norvegicus	98-106
2021116-6	1991	Drugs that interfere with the underlying compensatory mechanisms (e.g., renin-angiotensin system) without development of tolerance during long-term therapy exert beneficial effects after long-term treatment (e.g., the beneficial effects of angiotensin-converting enzyme inhibitors are, in part, due to peripheral mechanisms--the inability of the peripheral vessels to dilate--and to improvement of peripheral oxygen extraction).	Oxygen	409-415	renin	Homo sapiens	72-77
1941984-5	1991	The model predicts that a 10:1 change in LED intensity results in a 2.5% error at 50% arterial oxygen saturation (SpO2).	Oxygen	95-101	small integral membrane protein 10 like 2A	Homo sapiens	41-44
1849943-10	1991	These data confirm the requirement of [Ca2+]o for optimal priming of neutrophils by PAF and ionomycin (but not cells primed by PMA) and indicate that, under certain conditions, generation of O2- in response to FMLP in PAF-primed neutrophils can occur independent of any increase in [Ca2+]i.	Oxygen	191-193	formyl peptide receptor 1	Homo sapiens	210-214
1896252-11	1991	The low concentration of both CuZnSOD and MnSOD in the fetal lung tissues may contribute to the vulnerability to oxygen toxicity.	Oxygen	113-119	superoxide dismutase 1	Rattus norvegicus	30-37
1850253-0	1991	The polyphasic reduction of oxygen to water by purified cytochrome c oxidase.	Oxygen	28-34	cytochrome c, somatic	Homo sapiens	56-68
1830495-3	1991	Quantitative mRNA hybridization experiments using nodule-specific uricase (Nodulin-35) and sucrose synthase (Nodulin-100) cDNA probes confirmed that the synthesis of the uricase and sucrose synthase is controlled by oxygen at the mRNA level.	Oxygen	216-222	sucrose synthase	Glycine max	109-120
1850253-6	1991	The Vmax of O2 uptake was, however, a complex function of the concentrations of both enzyme and cytochrome c.	Oxygen	12-14	cytochrome c, somatic	Homo sapiens	96-108
2012803-0	1991	Effects of oxygen on the relative photodissociability of cytochrome P-450.CO complex in rat liver microsomes.	Oxygen	11-17	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	57-73
2012803-5	1991	The rate of CO recombination with cytochrome P-450 was decreased by increasing O2 concentration.	Oxygen	79-81	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	34-50
2007596-7	1991	The alignment also indicated that the distal helix of cholesterol 7 alpha-hydroxylase contained an asparagine in place of the well conserved threonine that is postulated to be involved in the O2 binding site.	Oxygen	192-194	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	54-85
1877354-4	1991	Resting O2 consumption increased by 15% from 279 +/- 7 ml min-1 (control) to 320 +/- 8 ml min-1 (stress, P less than 0.001).	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	58-63
1877354-4	1991	Resting O2 consumption increased by 15% from 279 +/- 7 ml min-1 (control) to 320 +/- 8 ml min-1 (stress, P less than 0.001).	Oxygen	8-10	CD59 molecule (CD59 blood group)	Homo sapiens	90-95
1901202-4	1991	The oxygen metabolite scavengers catalase (1,000 U/ml) and dimethylthiourea (30 mM) attenuated lung edema.	Oxygen	4-10	catalase	Oryctolagus cuniculus	33-41
1829903-3	1991	The concentration of plasma ANP was measured by radioimmunoassay of venous samples at 10 p.m., midnight, 6 p.m. and 8 p.m. All night sleep recordings were conducted with the static charge sensitive bed to monitor body and breathing movements and a BIOX III Pulse Oximeter for the blood oxygen saturation level.	Oxygen	286-292	natriuretic peptide A	Homo sapiens	28-31
1654782-9	1991	These results therefore suggest that the interaction of phenolic compounds, presumably by hydrogen-bonding, with the activity limiting distal amino acid residue(s) or with the ferryl oxygen of peroxidase may be an important contributing factor in the enhanced myeloperoxidase-dependent metabolism of hydroquinone in the presence of other phenolic compounds.	Oxygen	183-189	myeloperoxidase	Homo sapiens	260-275
1829903-9	1991	In a multivariate regression analysis age, percentage of active sleep during the night, BMI and the median oxygen saturation level during the night explained 76.4% of the total variance of ANP at 8 a.m.	Oxygen	107-113	natriuretic peptide A	Homo sapiens	189-192
1829903-10	1991	In a similar analysis the median oxygen saturation level during the night and BMI both explained the variance of ANP significantly.	Oxygen	33-39	natriuretic peptide A	Homo sapiens	113-116
2014917-2	1991	Angiotensin II increases myocardial oxygen consumption whilst reducing coronary flow and is also directly toxic to the myocardium.	Oxygen	36-42	angiotensinogen	Homo sapiens	0-14
2014919-1	1991	Reduced oxygen tension is regarded as the primary physiologic signal for the production of erythropoietin (EPO).	Oxygen	8-14	erythropoietin	Homo sapiens	91-105
2014919-1	1991	Reduced oxygen tension is regarded as the primary physiologic signal for the production of erythropoietin (EPO).	Oxygen	8-14	erythropoietin	Homo sapiens	107-110
2014919-10	1991	The data suggest that the production and release of EPO in the kidneys due to altered oxygen delivery is a fast-responding mechanism.	Oxygen	86-92	erythropoietin	Homo sapiens	52-55
1648368-1	1991	The effect of oxygen toxicity on the development of mammalian embryos was assessed by the use of superoxide dismutase (SOD), a potent scavenger of superoxide radicals.	Oxygen	14-20	superoxide dismutase 1	Homo sapiens	97-117
10148179-6	1991	Interpretation of p 50 is discussed in relation to evaluation of patients with hemoglobinopathies and as a parameter in estimating availability of oxygen to the tissues.	Oxygen	147-153	nuclear factor kappa B subunit 1	Homo sapiens	18-22
2054155-1	1991	The aim of this study was to examine the effect of reduced O2 tension on the glycosylation of transferrin.	Oxygen	59-61	transferrin	Rattus norvegicus	94-105
2007900-7	1991	We propose that the ability to increase CuZnSOD activity is the most important factor of the enzymatic oxygen free radical defense system for protection against hyperoxia-induced lung damage detected by MRI.	Oxygen	103-109	superoxide dismutase 1	Rattus norvegicus	40-47
2007900-8	1991	Even though lung Cu concentration was decreased in Cu deficiency, it seems that Cu-deficient rats are still able to increase lung CuZnSOD activity in response to 85% oxygen exposure.	Oxygen	166-172	superoxide dismutase 1	Rattus norvegicus	130-137
1648368-1	1991	The effect of oxygen toxicity on the development of mammalian embryos was assessed by the use of superoxide dismutase (SOD), a potent scavenger of superoxide radicals.	Oxygen	14-20	superoxide dismutase 1	Homo sapiens	119-122
2009275-1	1991	NADH oxidase of purified plasma membranes (electron transfer from NADH to oxygen) was stimulated by the growth factor diferric transferrin.	Oxygen	74-80	transferrin	Homo sapiens	127-138
2002018-2	1991	Mild oxidative stress, as elicited by ascorbate, oxygen, and trace metals, affects the binding properties of human serum albumin via purely conformational changes.	Oxygen	49-55	albumin	Homo sapiens	115-128
2035236-7	1991	In most cases exposure to oxygen caused an increase in GSSG-R, GSH-Px and G-6-PD activities.	Oxygen	26-32	glutathione peroxidase 1	Rattus norvegicus	63-69
1995228-13	1991	Vasodilators such as calcium channel blockers and ACE-inhibitors may improve pulmonary hemodynamics acutely, but may lower arterial PO2 by worsening ventilation-perfusion matching or blunt the improvement in pulmonary hemodynamics seen with supplemental oxygen.	Oxygen	254-260	angiotensin I converting enzyme	Homo sapiens	50-53
1859855-11	1991	The Egr-1 protein may play an important role in regulation of the response to ischemia of those segments of the nephron that are highly susceptible to oxygen deprivation and have a high level of intrinsic plasticity.	Oxygen	151-157	early growth response 1	Rattus norvegicus	4-9
1829435-6	1991	Plasma ANP levels were significantly reduced concomitantly with the reduction of PRA after oxygen, and stroke volume, PRA, pulmonary capillary wedge pressure (Pcw) after aminophylline, respectively.	Oxygen	91-97	natriuretic peptide A	Homo sapiens	7-10
1848176-1	1991	Transcription of the CTT1 (catalase T) gene of Saccharomyces cerevisiae is controlled by oxygen via heme, by nutrients via cAMP and by heat shock.	Oxygen	89-95	catalase T	Saccharomyces cerevisiae S288C	21-25
1848176-1	1991	Transcription of the CTT1 (catalase T) gene of Saccharomyces cerevisiae is controlled by oxygen via heme, by nutrients via cAMP and by heat shock.	Oxygen	89-95	catalase T	Saccharomyces cerevisiae S288C	27-37
1848514-5	1991	Superoxide dismutase, catalase, and dimethyl sulfoxide were utilized as scavengers of O2-, H2O2, and OH., respectively.	Oxygen	86-89	catalase	Homo sapiens	22-30
2034478-3	1991	We found that although full-term newborns exposed to greater than 90% O2 consistently showed elevated superoxide dismutase, catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase activities, the premature animals repeatedly failed to respond to hyperoxia with increased antioxidant enzyme activity levels.	Oxygen	70-72	catalase	Oryctolagus cuniculus	124-132
2034478-3	1991	We found that although full-term newborns exposed to greater than 90% O2 consistently showed elevated superoxide dismutase, catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase activities, the premature animals repeatedly failed to respond to hyperoxia with increased antioxidant enzyme activity levels.	Oxygen	70-72	glucose-6-phosphate 1-dehydrogenase	Oryctolagus cuniculus	162-195
1991071-1	1991	Exposure of adult rats to 85% ambient oxygen increased the content of surfactant proteins SP-A, SP-B, and SP-C recovered from alveolar lavage.	Oxygen	38-44	surfactant protein A1	Rattus norvegicus	90-94
1991071-1	1991	Exposure of adult rats to 85% ambient oxygen increased the content of surfactant proteins SP-A, SP-B, and SP-C recovered from alveolar lavage.	Oxygen	38-44	surfactant protein C	Rattus norvegicus	106-110
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	105-111	surfactant protein A1	Rattus norvegicus	19-23
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	105-111	surfactant protein C	Rattus norvegicus	61-65
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	176-182	surfactant protein A1	Rattus norvegicus	19-23
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	176-182	surfactant protein C	Rattus norvegicus	61-65
2032988-5	1991	However, when fetuses were ventilated with 100% oxygen, 100- and 300-ng doses of ET-1 decreased PVR/kg by 5 and 9%, respectively.	Oxygen	48-54	endothelin-1	Ovis aries	81-85
1900814-6	1991	The energy of activation of oxygen utilization by ascorbate and Cu(II) in the absence or presence of fibrinogen is Ea = 6.1 and 7.9 Kcal/mol, respectively.	Oxygen	28-34	fibrinogen beta chain	Homo sapiens	101-111
1900814-9	1991	The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction.	Oxygen	52-58	fibrinogen beta chain	Homo sapiens	208-218
2063982-9	1991	Only one patient with cardiac disease needed oxygen adjonction (2 l.min-1) to raise his SaO2 level above 95%.	Oxygen	45-51	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
2020093-11	1991	Nevertheless two patients in each group required oxygen 2 liter.min-1 via a nasal catheter.	Oxygen	49-55	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
1846161-5	1991	Although pertussis toxin-treated cells showed a greatly diminished O2- response (by 89%) to FMLP, the response to immune complexes was largely resistant (only 26% reduction) to the inhibitory effects of this toxin.	Oxygen	67-69	formyl peptide receptor 1	Homo sapiens	92-96
1846358-4	1991	The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation.	Oxygen	215-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
2039611-2	1991	The indole NH group is hydrogen bonded to the amide oxygen, O15" (related by chi, 0.5 -y, -0.5 + z), of the indolizine moiety with relevant parameters: N...O 2.79 (2)A, H...O 2.02 (15) A, N-H...O 145 (14) degrees.	Oxygen	52-58	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	60-63
1844104-2	1991	The measurement of transcutaneous PtcO2 in eight normal adults prove a comparable efficacy of 50 l.min-1 O2 through facial "small mask" (61.5 kPa; 463 mmHg) and 20 l.min-1 O2 through head tent (65.1 kPa; 490 mmHg).	Oxygen	105-107	CD59 molecule (CD59 blood group)	Homo sapiens	99-104
30260337-5	1991	Superoxide dismutase, catalase, and some radical scavengers inhibited the generation of these active oxygen molecules.	Oxygen	101-107	catalase	Homo sapiens	22-30
2019080-2	1991	For COPD patients the maximum oxygen uptake (VOmax) was 19.6 +/- 3.8 ml kg-1 min-1 (+/- SD), and percentage of forced expired volume at 1 s (% FEV1) was 47.8 +/- 10.4%.	Oxygen	30-36	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
1827977-8	1991	The intravenous application of nitroprusside and the ACE-inhibitor benazepril decreased both the systolic stress-time integral and the myocardial oxygen consumption in proportion to each other, indicating unchanged economy of myocardial contraction.	Oxygen	146-152	angiotensin I converting enzyme	Homo sapiens	53-56
1827982-5	1991	The study addresses the question of whether regression of dilation, induced by the ACE-inhibitor treatment, improves the oxygen supply-demand ratio and, as a result, the contractility of the heart muscle.	Oxygen	121-127	angiotensin I converting enzyme	Homo sapiens	83-86
1773815-5	1991	These changes were associated with a small increase in the mean oxygen consumption over all levels of rest and exercise (0.86 l min-1 vs 0.82 l min-1, P less than 0.001) and a corresponding increase in mean energy expenditure (294 W vs 283 W, P less than 0.05).	Oxygen	64-70	CD59 molecule (CD59 blood group)	Homo sapiens	128-133
1673911-10	1991	The results indicate that the amino acid sequences of TH are highly conserved among various species, and that TH consists of the regulatory domain containing serine residues which are phosphorylated by protein kinases and of the catalytic domain where the substrates, tyrosine and oxygen, and the cofactor, tetrahydrobiopterin, are bound.	Oxygen	281-287	tyrosine hydroxylase	Homo sapiens	54-56
1673911-10	1991	The results indicate that the amino acid sequences of TH are highly conserved among various species, and that TH consists of the regulatory domain containing serine residues which are phosphorylated by protein kinases and of the catalytic domain where the substrates, tyrosine and oxygen, and the cofactor, tetrahydrobiopterin, are bound.	Oxygen	281-287	tyrosine hydroxylase	Homo sapiens	110-112
1773815-5	1991	These changes were associated with a small increase in the mean oxygen consumption over all levels of rest and exercise (0.86 l min-1 vs 0.82 l min-1, P less than 0.001) and a corresponding increase in mean energy expenditure (294 W vs 283 W, P less than 0.05).	Oxygen	64-70	CD59 molecule (CD59 blood group)	Homo sapiens	144-149
1649090-3	1991	With the indirect methods of cytochrome c and NBT for determining the ability of these complexes to catalyze O2 dismutation, these compounds exhibited a much lower SOD activity, and kcat was determined to be (5.0 +/- 0.3) x 10(6) and (7.6 +/- 0.4) x 10(7) M-1s-1, respectively using the two assays.	Oxygen	109-111	cytochrome c, somatic	Homo sapiens	29-41
1649094-1	1991	The active site Cu ion in Cu,Zn superoxide dismutase is alternately oxidized and reduced during the enzymatic dismutation of superoxide to hydrogen peroxide and molecular oxygen.	Oxygen	171-177	superoxide dismutase 1	Homo sapiens	26-52
2071045-4	1991	Only native Cu,Zn-superoxide dismutase and metallothionein showed competitive behavior, with SOD exhibiting rate constants close to the dismutation rate for O2-.	Oxygen	157-159	superoxide dismutase 1	Homo sapiens	93-96
2060832-1	1991	Superoxide dismutase (SOD) has demonstrated therapeutic potential for treating a variety of conditions including radiation injury, oxygen toxicity, reperfusion injury, and inflammation, especially arthritis.	Oxygen	131-137	superoxide dismutase 1	Homo sapiens	0-20
2060832-1	1991	Superoxide dismutase (SOD) has demonstrated therapeutic potential for treating a variety of conditions including radiation injury, oxygen toxicity, reperfusion injury, and inflammation, especially arthritis.	Oxygen	131-137	superoxide dismutase 1	Homo sapiens	22-25
1672675-2	1991	Intraperitoneal superoxide dismutase (SOD) and catalase were used to block the toxic effects of superoxide anion (O2) and hydrogen peroxide (H2O2), associated with the production of endometriosis and inflammation in a rabbit model.	Oxygen	114-116	catalase	Oryctolagus cuniculus	47-55
1663088-4	1991	We found that azelastine, one of the antiallergic drugs, and isoproterenol inhibited FMLP-induced O2- generation in a dose-dependent fashion, whereas the other drugs exhibited no such inhibitory action except at very high concentrations.	Oxygen	98-100	formyl peptide receptor 1	Homo sapiens	85-89
1662971-2	1991	FMLP stimulates reactive oxygen intermediate production in these cells, whilst M-CSF stimulates DNA synthesis.	Oxygen	25-31	formyl peptide receptor 1	Homo sapiens	0-4
1743765-9	1991	The calculated (from HR measurements) average oxygen consumption (VO2) varied from 0.9 to 1.9 l min-1, which corresponded to 27%-60% of the maximal value.	Oxygen	46-52	CD59 molecule (CD59 blood group)	Homo sapiens	96-101
1725350-5	1991	Taken together, our results may suggest that the negative feedback regulation of cerebral blood flow through oxygen and carbon dioxide pressure is mediated by ET-1 produced locally by cerebral microvessel endothelia.	Oxygen	109-115	endothelin 1	Homo sapiens	159-163
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	formyl peptide receptor 1	Homo sapiens	47-51
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	tumor necrosis factor	Homo sapiens	53-56
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	fibronectin 1	Homo sapiens	161-172
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	fibronectin 1	Homo sapiens	174-176
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	fibrinogen beta chain	Homo sapiens	231-241
1687968-2	1991	Of the agonists used, PAF and LPS failed to induce a response in any of the above conditions; FMLP and PMA stimulated neutrophils to produce similar amounts of O2- either in suspension or on biological surfaces; TNF induced O2- production only by cells residing on FN, FBG and FBN.	Oxygen	160-162	formyl peptide receptor 1	Homo sapiens	94-98
1687968-2	1991	Of the agonists used, PAF and LPS failed to induce a response in any of the above conditions; FMLP and PMA stimulated neutrophils to produce similar amounts of O2- either in suspension or on biological surfaces; TNF induced O2- production only by cells residing on FN, FBG and FBN.	Oxygen	224-226	tumor necrosis factor	Homo sapiens	212-215
1687968-8	1991	The TNF-induced increase in adherence to LM, that was not accompanied by an increase in O2- release, was also inhibited by the monoclonal antibody.	Oxygen	88-90	tumor necrosis factor	Homo sapiens	4-7
1725380-1	1991	The pulmonary vascular reactivity to endothelin-1 (ET-1) was assessed in rats previously exposed to 11% O2 (hypoxic) or room air (controls) for 3 weeks.	Oxygen	104-106	endothelin 1	Rattus norvegicus	37-49
1817160-3	1991	Hence, the much lower contribution by outward transport to the spontaneous efflux of 3H-noradrenaline in vas deferens than atria is likely to be due to a better supply of oxygen (and perhaps also glucose) to the 3H-noradrenaline-storing varicosities in vas deferens than in atria.	Oxygen	171-177	arginine vasopressin	Rattus norvegicus	105-108
1787554-8	1991	The average increase in oxygen uptake above pre-exercise levels during the sprint test was greater for endurance-trained athletes than for the games players (ET vs GP: 35.0 +/- 2.2 vs 29.6 +/- 3.0 ml kg-1 min-1, P less than 0.05), corresponding to an average oxygen uptake per sprint (6-s sprint and 24 s of subsequent recovery) of 67.5 +/- 2.9% and 63.0 +/- 4.5% VO2 max respectively (N.S.).	Oxygen	24-30	CD59 molecule (CD59 blood group)	Homo sapiens	205-210
2038069-5	1991	The functional impairment was slower when hypoxanthine was replaced by xanthine, and was eliminated by superoxide dismutase and catalase, indicating that the injury is caused by toxic oxygen species generated from hypoxanthine and xanthine oxidase.	Oxygen	184-190	catalase	Rattus norvegicus	128-136
2016989-1	1991	Vasoconstriction by norepinephrine, angiotensin II and vasopressin in the constant-flow perfused rat hindlimb is associated with increased oxygen uptake and has given rise to the concept of vascular thermogenesis.	Oxygen	139-145	angiotensinogen	Rattus norvegicus	36-50
2016989-1	1991	Vasoconstriction by norepinephrine, angiotensin II and vasopressin in the constant-flow perfused rat hindlimb is associated with increased oxygen uptake and has given rise to the concept of vascular thermogenesis.	Oxygen	139-145	arginine vasopressin	Rattus norvegicus	55-66
1662784-4	1991	The Epo secretion is stimulated by hypoxia, which is detected by an oxygen sensor.	Oxygen	68-74	erythropoietin	Homo sapiens	4-7
1758756-0	1991	Prevention of chronic pulmonary oxygen toxicity in young rats with liposome-encapsulated catalase administered intratracheally.	Oxygen	32-38	catalase	Rattus norvegicus	89-97
1663613-9	1991	Indole-3-carbinol was capable of forming compounds that bind to the Ah receptor under a variety of conditions: in fecal suspensions with or without oxygen, in 50 mM HCl for 80 minutes, and in neutral pH buffer overnight at 37 degrees C. Addition of oxygenated tryptophan-fecal incubation extracts to Hepa 1 and Hepa c4 mutant (defective Ah receptor) cell cultures resulted in the induction of ethoxyresorufin O-deethylase activity in Hepa 1 cells, but no induction was observed in Hepa c4 cells.	Oxygen	148-154	aryl-hydrocarbon receptor	Mus musculus	68-79
1758756-5	1991	Daily intratracheal administration of liposome-encapsulated CAT (160 U) during the O2 exposure prevented these chronic changes.	Oxygen	83-85	catalase	Rattus norvegicus	60-63
1758756-7	1991	During the first 3 to 5 days following oxygen exposure the lung tissue enzymes SOD, CAT, and glutathione peroxidase markedly increased.	Oxygen	39-45	catalase	Rattus norvegicus	84-87
1758756-8	1991	We conclude that in the young rat animal model liposome-encapsulated CAT (160 U) given intratracheally during the period of O2 exposure is safe and will prevent the chronic vascular and parenchymal damage due to oxygen toxicity.	Oxygen	124-126	catalase	Rattus norvegicus	69-72
1758756-8	1991	We conclude that in the young rat animal model liposome-encapsulated CAT (160 U) given intratracheally during the period of O2 exposure is safe and will prevent the chronic vascular and parenchymal damage due to oxygen toxicity.	Oxygen	212-218	catalase	Rattus norvegicus	69-72
1788391-3	1991	Insulin and thyroid hormones are controlled by the supply of glucose and oxygen, respectively, and they influence fetal growth, partly via IGF-I.	Oxygen	73-79	insulin	Homo sapiens	0-7
1812974-3	1991	The first hypothesis concerns the role of the oxygen binding hemoprotein cytochrome P-450.	Oxygen	46-52	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-89
2265990-1	1990	Superoxide dismutase (SOD) molecules occur in all cells exposed to an oxygen-containing environment, including retinal pigment epithelial (RPE) cells.	Oxygen	70-76	superoxide dismutase 1	Homo sapiens	22-25
1962173-6	1991	The remainder of part 2 is devoted to the many factors influencing the recording of an ERG, notably pupillary diameter, anesthesia, oxygen and glucose supply to the animal, body temperature of the patient, its intraocular pressure and level of retinal adaptation, and finally the age of the patient.	Oxygen	132-138	ETS transcription factor ERG	Homo sapiens	87-90
2174739-3	1990	It is shown that ditercalinium probably inhibits the electron transfer between membrane cytochrome c and oxygen (cytochrome c oxidase activity) and the electron transfer between the matrix side of inner membrane (Complexes II and III) and membrane cytochrome c.	Oxygen	105-111	cytochrome c, somatic	Homo sapiens	113-125
2174739-3	1990	It is shown that ditercalinium probably inhibits the electron transfer between membrane cytochrome c and oxygen (cytochrome c oxidase activity) and the electron transfer between the matrix side of inner membrane (Complexes II and III) and membrane cytochrome c.	Oxygen	105-111	cytochrome c, somatic	Homo sapiens	113-125
2124139-3	1990	This finding provides strong evidence for a regioselective oxidative attack by cytochrome P-450-dependent monooxygenase with preferential insertion of oxygen at meta-para unsubstituted carbon atoms.	Oxygen	110-116	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	79-95
2177322-5	1990	The second electron from ubiquinol is diverted to oxygen by the isolated Rieske protein, and forms oxygen radicals that contribute to the steady-state reduction of cytochrome c.	Oxygen	50-56	cytochrome c, somatic	Homo sapiens	164-176
1780738-7	1991	Myocardial oxygen consumption increased 70.7 +/- 15.6% in the dopamine group and 78.8 +/- 18.4% in the insulin-dopamine group (NS).	Oxygen	11-17	insulin	Homo sapiens	103-110
1780738-8	1991	The addition of high-dose insulin to dopamine thus improved the haemodynamic efficacy of dopamine without further increasing myocardial oxygen expenditure.	Oxygen	136-142	insulin	Homo sapiens	26-33
1651573-2	1991	To determine the cytotoxicity of myeloperoxidase-generated oxygen metabolites (mainly chlorinated oxidants such as hypochlorite) and catechol oxidation products, the well characterized erythrocyte was used as a target.	Oxygen	59-65	myeloperoxidase	Homo sapiens	33-48
1654602-6	1991	Two components of the monooxygenase system responsible for BP metabolism, cytochrome P-450 and NADPH-cytochrome P-450 reductase, are also inhibited by the two oxygen metabolites in a similar manner.	Oxygen	26-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-90
1962845-4	1990	Both the Ca2(+)-pump and Na(+)-Ca2+ exchange activities in control heart sarcolemmal preparations were depressed by activated oxygen-generating systems containing xanthine plus xanthine oxidase and H2O2; these changes were prevented by the inclusion of superoxide dismutase and catalase in the incubation medium.	Oxygen	126-132	catalase	Rattus norvegicus	278-286
2147139-0	1990	Increased release of the N-terminus of the atrial natriuretic factor prohormone with increasing absolute atmospheres of pressure in a hyperbaric chamber and reversal with oxygen therapy.	Oxygen	171-177	natriuretic peptide A	Homo sapiens	43-68
2147139-6	1990	With the addition of 100 percent O2 while at 3 and 2 ATA, the circulating concentrations of both the whole N-terminus and pro ANF 31-67 immediately decreased to their prehyperbaric ATA levels and remained there with further decompression to 1 ATA and removal of O2 supplementation.	Oxygen	33-35	natriuretic peptide A	Homo sapiens	126-129
1704974-7	1990	Compared to baseline, the arterial-coronary sinus O2 content difference and myocardial O2 extraction diminished progressively at the 0.03, 0.10, and 0.30 micrograms/min doses of VIP (118 +/- 12 ml O2/L vs. 94 +/- 15, 70 +/- 9, and 61 +/- 26 ml O2/L, respectively, and 0.64 +/- 0.05 vs. 0.53 +/- 0.10, 0.38 +/- 0.06, and 0.34 +/- 0.15, respectively).	Oxygen	50-52	vasoactive intestinal peptide	Homo sapiens	178-181
1704974-7	1990	Compared to baseline, the arterial-coronary sinus O2 content difference and myocardial O2 extraction diminished progressively at the 0.03, 0.10, and 0.30 micrograms/min doses of VIP (118 +/- 12 ml O2/L vs. 94 +/- 15, 70 +/- 9, and 61 +/- 26 ml O2/L, respectively, and 0.64 +/- 0.05 vs. 0.53 +/- 0.10, 0.38 +/- 0.06, and 0.34 +/- 0.15, respectively).	Oxygen	87-89	vasoactive intestinal peptide	Homo sapiens	178-181
1704974-7	1990	Compared to baseline, the arterial-coronary sinus O2 content difference and myocardial O2 extraction diminished progressively at the 0.03, 0.10, and 0.30 micrograms/min doses of VIP (118 +/- 12 ml O2/L vs. 94 +/- 15, 70 +/- 9, and 61 +/- 26 ml O2/L, respectively, and 0.64 +/- 0.05 vs. 0.53 +/- 0.10, 0.38 +/- 0.06, and 0.34 +/- 0.15, respectively).	Oxygen	87-89	vasoactive intestinal peptide	Homo sapiens	178-181
2259706-5	1990	The distribution of blood flow and oxygen uptake between the two uterine horns was strongly correlated with placental mass distribution.	Oxygen	35-41	Horns	Ovis aries	73-78
2124706-3	1990	This blood oxygenation level-dependent (BOLD) contrast follows blood oxygen changes induced by anesthetics, by insulin-induced hypoglycemia, and by inhaled gas mixtures that alter metabolic demand or blood flow.	Oxygen	11-17	insulin	Homo sapiens	111-118
2258638-4	1990	Sixty minutes of preincubation of PMN with 1 microgram/ml TNF alpha or 10 micrograms/ml LPS resulted in similar priming for the respiratory burst elicited by opsonized zymosan, phorbol myristate acetate, zymosan, zymosan-activated serum, aggregated immunoglobulin, and f-met-leu-phe (FMLP) depending on the method of measurement used, i.e., chemiluminescence, production of O2-, and H2O2.	Oxygen	374-376	tumor necrosis factor	Homo sapiens	58-67
2208168-9	1990	Studies on the expression and activity of cytochrome P-450 in liver nodules as well as experiments with specific inhibitors point towards a participation of the liver monooxygenase system in reactive oxygen formation, although additional metabolic pathways seem to be involved as well.	Oxygen	171-177	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-58
2246244-0	1990	Kinetics and thermodynamics of oxygen, CO, and azide binding by the subcomponents of soybean leghemoglobin.	Oxygen	31-37	leghemoglobin A	Glycine max	93-106
2246244-1	1990	Leghemoglobin shows extreme high affinity behavior in the binding of both oxygen and CO.	Oxygen	74-80	leghemoglobin A	Glycine max	0-13
2246244-5	1990	At 20 degrees C the rate constants for oxygen and CO binding vary by 26-44% among the eight leghemoglobin components.	Oxygen	39-45	leghemoglobin A	Glycine max	92-105
2246244-10	1990	This finding calls into question models that ascribe a significant functional role to changes in the distribution of leghemoglobin components in regulating oxygen concentration in the nodule.	Oxygen	156-162	leghemoglobin A	Glycine max	117-130
2075928-5	1990	As hypoxia is universal for any CRD the index of mixed venous blood saturation with O2 (Sv-O2) was considered as a factor determining hypoxic ODC shift and a numerical contribution of hypoxia to P50 changes has been determined.	Oxygen	84-86	nuclear factor kappa B subunit 1	Homo sapiens	195-198
2289871-1	1990	Human polymorphonuclear leukocytes (PMN) respond via pertussis toxin-sensitive pathways to extracellular nucleotides with an elevation in intracellular calcium ([Ca2+]i) and enhancement of the O2- generation induced by the chemotactic peptide N"-formyl-Met-Leu-Phe (fMLP).	Oxygen	193-195	formyl peptide receptor 1	Homo sapiens	266-270
2169024-1	1990	The Saccharomyces cerevisiae COX5b gene is regulated at the level of transcription by both the carbon source and oxygen.	Oxygen	113-119	cytochrome c oxidase subunit Vb	Saccharomyces cerevisiae S288C	29-34
2230644-1	1990	Acceleration of the autoxidation of Fe2+ by apotransferrin or apolactoferrin at acid pH is indicated by the disappearance of Fe2+, the uptake of oxygen, and the binding of iron to transferrin or lactoferrin.	Oxygen	145-151	transferrin	Homo sapiens	47-58
2237979-7	1990	If Ca2+ is withdrawn before hypoxia, then synaptic function recovers upon restoration of oxygen and [Ca2+]o, despite prolonged spreading depression.	Oxygen	89-95	carbonic anhydrase 2	Rattus norvegicus	3-6
2221078-3	1990	The purpose of this study was to determine if lipids bound to gastric mucin protect the mucin from oxygen radical attack.	Oxygen	99-105	LOC100188911	Sus scrofa	62-75
2124989-7	1990	The results suggest that an intact excretory renal function is not a prerequisite for the capability to produce EPO, but correlates with the oxygen-dependent regulation of EPO formation.	Oxygen	141-147	erythropoietin	Homo sapiens	172-175
2287808-5	1990	We have selected in the first group 10 patients with low hemoglobin oxygen affinity (p50 28.6 +/- 1.37 mmHg), in the second one 7 patients with normal values (p50 26.6 +/- 0.84 mmHg).	Oxygen	68-74	nuclear factor kappa B subunit 1	Homo sapiens	85-88
2120135-8	1990	The induction of poly-ADP-ribose synthesis by PMA and BP appears to be mediated at least in part by active oxygen species, as they induced an increase in superoxide anions and anti-oxidants prevented the increase of poly-ADPRT activity to varying extents.	Oxygen	107-113	poly(ADP-ribose) polymerase 1	Homo sapiens	221-226
2242020-2	1990	With 95% O2-saturated perfusate, infusion of 0.5 mM CCl4 caused an instantaneous increase of thiobarbituric acid reactive substances (TBA-RS) in the effluent perfusate, accompanied by only a slight leakage of K+ and lactate dehydrogenase (LDH).	Oxygen	9-11	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
2242020-4	1990	With 20% O2-saturated perfusate, CCl4 caused a marked LDH leakage, which was preceded by an early and considerable increase in K+ leakage coupled with Na+ uptake, Ca2+ uptake was initially slight, being enhanced concurrently with the LDH leakage.	Oxygen	9-11	C-C motif chemokine ligand 4	Rattus norvegicus	33-37
2242020-8	1990	In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion.	Oxygen	34-40	C-C motif chemokine ligand 4	Rattus norvegicus	59-63
2242020-10	1990	Thus, oxygen deficiency, rather than lipid peroxidation by itself, and the essential role of extracellular Ca2+ may be important for CCl4-induced hepatic cell necrosis, in which plasma membrane permeability change may be an early and critical event.	Oxygen	6-12	C-C motif chemokine ligand 4	Rattus norvegicus	133-137
2222041-3	1990	After simple clamping of the aorta, oxygen tension decreased significantly distal to the clamping site both after occlusion of the thoracic aorta at T3-4 (group 1) and after occlusion of the abdominal aorta at L-1 (group 2).	Oxygen	36-42	L1 cell adhesion molecule	Homo sapiens	210-213
2249886-1	1990	Experimental acute lung injury mediated by reactive metabolites of oxygen can be inhibited by the antioxidant enzymes catalase and superoxide dismutase (SOD).	Oxygen	67-73	catalase	Homo sapiens	118-126
2249886-1	1990	Experimental acute lung injury mediated by reactive metabolites of oxygen can be inhibited by the antioxidant enzymes catalase and superoxide dismutase (SOD).	Oxygen	67-73	superoxide dismutase 1	Homo sapiens	131-151
2249886-1	1990	Experimental acute lung injury mediated by reactive metabolites of oxygen can be inhibited by the antioxidant enzymes catalase and superoxide dismutase (SOD).	Oxygen	67-73	superoxide dismutase 1	Homo sapiens	153-156
2089418-3	1990	Second, when bound to cytochrome c (Cyt c), Rh 123 photosensitizes ferro Cyt c but not ferri Cyt c degradation by an oxygen-independent process.	Oxygen	117-123	cytochrome c, somatic	Homo sapiens	22-34
2089418-3	1990	Second, when bound to cytochrome c (Cyt c), Rh 123 photosensitizes ferro Cyt c but not ferri Cyt c degradation by an oxygen-independent process.	Oxygen	117-123	cytochrome c, somatic	Homo sapiens	36-41
2170978-3	1990	Moreover, comparison of the time course of cytochrome c oxidation and cytochrome a3 reduction indicates that two electrons are transferred internally and with different rates to the oxygen-binding site.	Oxygen	182-188	cytochrome c, somatic	Homo sapiens	43-55
2122605-0	1990	Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride.	Oxygen	49-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
2290835-6	1990	The orientation of histidine residues is usually stabilized through hydrogen bonding; ND1-protonated form of a helical residue can form a hydrogen bond with the carbonyl oxygen atom in the preceding turn of the helix.	Oxygen	170-176	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	86-89
2168410-7	1990	These results suggest that the formation of nitroxide radical by 1O2 attack on TEMP may be used as a simple and specific assay for 1O2, and VIP can serve as an effective 1O2 scavenger/quencher, thus it may modulate the oxidative tissue injury caused by this reactive species of oxygen.	Oxygen	278-284	vasoactive intestinal peptide	Homo sapiens	140-143
1965503-1	1990	Myeloperoxidase (MPO) plays an important role in the oxygen-dependent microbicidal mechanism of polymorphonuclear neutrophils.	Oxygen	53-59	myeloperoxidase	Homo sapiens	0-15
1965503-1	1990	Myeloperoxidase (MPO) plays an important role in the oxygen-dependent microbicidal mechanism of polymorphonuclear neutrophils.	Oxygen	53-59	myeloperoxidase	Homo sapiens	17-20
2122607-16	1990	It is concluded that although NADPH-cytochrome P-450 reductase is active in the one-electron reduction of mitomycin c, the actual metabolic locus for the reduction of this compound in liver microsomes under a relatively low O2 tension is more likely the haem site of cytochrome P-450.	Oxygen	224-226	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
2226427-7	1990	In the heaviest tasks the oxygen consumption was 1.2 +/- 0.41 min-1, and no elevated blood lactate concentrations were found.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	62-67
24420353-1	1990	The relation between the quantum yield of oxygen evolution of open photosystem II reactions centers (Phip), calculated according to Weis and Berry (1987), and non-photochemical quenching of chlorophyll fluorescence of plants grown at 19 C and 7 C was measured at 19 C and 7 C. The relation was linear when measured at 19 C, but when measured at 7 C a deviation from linearity was observed at high values of non-photochemical quenching.	Oxygen	42-48	pleckstrin homology domain interacting protein	Homo sapiens	101-105
2122607-8	1990	Under aerobic conditions the H2O2 production in the microsomal systems was dependent on NADPH, O2 and mitomycin c, and was inhibited by the cytochrome P-450 inhibitors, metyrapone and SKF-525A.	Oxygen	31-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-156
2115743-3	1990	In blood-perfused lungs undergoing hypoxic (3% O2) vasoconstriction, repeated additions of 0.5 nM ET-1 to the perfusate elicited transient partial vasodilations.	Oxygen	47-49	endothelin 1	Rattus norvegicus	98-102
2143636-2	1990	Intracerebroventricular injection of a recombinant fragment of lipocortin 1 (NH2-terminal 1-188) caused dose-dependent (0.4-1.2 micrograms) reductions in the acute increases in colonic temperature and oxygen consumption, which occurred in response to central injections of recombinant interleukin 1 beta and gamma-interferon in conscious rats.	Oxygen	201-207	annexin A1	Rattus norvegicus	63-75
2164483-5	1990	Neutrophils treated with the calcium ionophore A23187 or with the peptide FMLP produced O2- to a much lesser degree when incubated in contact with ECM-coated surfaces than did those incubated in contact with uncoated polystyrene culture dishes.	Oxygen	88-90	formyl peptide receptor 1	Homo sapiens	74-78
2164483-8	1990	Experiments with isolated constituents of the ECM revealed that fibronectin but not collagen type IV or laminin could partially inhibit O2- production by Ca2+ ionophore-stimulated neutrophils.	Oxygen	136-138	fibronectin 1	Homo sapiens	64-75
2205778-4	1990	In other experimental muscle injury models, elevated [Ca2+]i appears to cause release of muscle enzymes through activation of phospholipase A2, which in turn could induce injury to sarcolemma through production of leukotrienes and prostaglandins, through free O2 radical formation (in the subsequent lipoxygenase and cyclooxygenase reactions), and/or through release of detergent lysophospholipids.	Oxygen	260-262	phospholipase A2 group IB	Homo sapiens	126-142
2387419-0	1990	Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface.	Oxygen	14-20	superoxide dismutase 1	Homo sapiens	43-63
2387419-1	1990	Since enzymes that degrade reactive oxygens, such as superoxide dismutase (SOD), are significantly lower in plasma than in intracellular compartments, cell surface membranes should be protected against hazardous oxygens particularly when animals are challenged with oxidative stress.	Oxygen	36-43	superoxide dismutase 1	Homo sapiens	53-73
2387419-1	1990	Since enzymes that degrade reactive oxygens, such as superoxide dismutase (SOD), are significantly lower in plasma than in intracellular compartments, cell surface membranes should be protected against hazardous oxygens particularly when animals are challenged with oxidative stress.	Oxygen	36-43	superoxide dismutase 1	Homo sapiens	75-78
2382732-8	1990	The results indicate that VIP has potent protective activity against injury triggered by xanthine/xanthine oxidase and may be a physiological modulator of inflammatory tissue damage associated with toxic oxygen metabolites.	Oxygen	204-210	vasoactive intestinal peptide	Rattus norvegicus	26-29
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	Oxygen	155-157	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	31-35
2242219-6	1990	However, if solubilization is carried out under anaerobic conditions, the reduced spectra can be retained, suggesting that the solubilized choline dehydrogenase can use oxygen as an acceptor.	Oxygen	169-175	choline dehydrogenase	Rattus norvegicus	139-160
2382218-7	1990	Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p less than 0.05).	Oxygen	59-65	insulin like growth factor 1	Homo sapiens	15-20
2115743-5	1990	In nine conscious rats exposed to 8% O2, intravenous ET-1 (0.2 nmol/kg) reversed the hypoxic pressor response by 63 +/- 8% without affecting cardiac output.	Oxygen	37-39	endothelin 1	Rattus norvegicus	53-57
1976077-5	1990	Viability of the incubated slices was verified by determining intracellular K+ content and levels of cytochrome P-450, which were maintained under 95% O2 atmosphere but decreased with lower O2 tensions (2.5%).	Oxygen	151-153	cytochrome P450 3A14	Cavia porcellus	101-117
1976077-5	1990	Viability of the incubated slices was verified by determining intracellular K+ content and levels of cytochrome P-450, which were maintained under 95% O2 atmosphere but decreased with lower O2 tensions (2.5%).	Oxygen	190-192	cytochrome P450 3A14	Cavia porcellus	101-117
2362274-7	1990	Superposition of the crystallographic structures of four ACE ligands shows that the observed extended conformations place the pharmacophores, zinc atom ligand, carbonyl oxygen atom, and carboxyl group, in juxtaposition and provide an alternative model for the interaction of ligands with the ACE active site.	Oxygen	169-175	angiotensin I converting enzyme	Homo sapiens	57-60
2373486-4	1990	Vasopressin effects on systemic O2 consumption were also studied.	Oxygen	32-34	arginine vasopressin	Homo sapiens	0-11
2362274-7	1990	Superposition of the crystallographic structures of four ACE ligands shows that the observed extended conformations place the pharmacophores, zinc atom ligand, carbonyl oxygen atom, and carboxyl group, in juxtaposition and provide an alternative model for the interaction of ligands with the ACE active site.	Oxygen	169-175	angiotensin I converting enzyme	Homo sapiens	292-295
2164216-4	1990	(ii) With O2-., Cu,Zn-SOD causes the appearance of intense resonance signals due to DMPO-OH adducts.	Oxygen	10-12	superoxide dismutase 1	Homo sapiens	16-25
2366819-6	1990	The observed parallelism between the SOD activity and the cytogenetic manifestation may imply an involvement of active oxygen species, especially superoxide radicals, in the increased chromosome damage of CIS cells.	Oxygen	119-125	superoxide dismutase 1	Homo sapiens	37-40
2112405-10	1990	Flosequinan increased the oxygen uptake at anaerobic threshold from 13.2 +/- 2.8 ml min-1 kg-1 to 15.9 +/- 3.4 ml min-1 kg-1 at week 2 and 15.8 +/- 3.7 ml min-1 kg-1 at week 8.	Oxygen	26-32	CD59 molecule (CD59 blood group)	Homo sapiens	84-94
2162339-5	1990	This system will facilitate the purification and analysis of factors and sequences required for Epo gene transcription in response to changes in tissue oxygen tension.	Oxygen	152-158	erythropoietin	Homo sapiens	96-99
2396997-2	1990	After vinpocetine administration, oxygen affinity of hemoglobin (P50) was significantly increased (26.5 +/- 0.55 to 27.6 +/- 0.62 mmHg; mean and standard deviation, p less than 0.05), red blood cell (RBC) ATP concentrations were significantly increased (846 +/- 168 to 1,158 +/- 130 mumol/l RBC, p less than 0.05), while DPG concentrations were unaltered (4.46 +/- 0.48 to 4.59 +/- 0.57 mmol/l RBC).	Oxygen	34-40	nuclear factor kappa B subunit 1	Homo sapiens	53-68
2165892-6	1990	Oxygen uptake was reduced from 147 +/- 16 ml STP min-1 m-2 in the control subjects to 112 +/- 9 ml STP min-1 m-2 in the patients.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
2165892-6	1990	Oxygen uptake was reduced from 147 +/- 16 ml STP min-1 m-2 in the control subjects to 112 +/- 9 ml STP min-1 m-2 in the patients.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
2187994-2	1990	Molecular modeling suggests that the heterocyclic oxygen hydrogen bonds as an acceptor to the flap region of renin and that the second hydroxyl in the glycol-based inhibitors behaves similarly.	Oxygen	50-56	renin	Homo sapiens	109-114
2187871-1	1990	The Saccharomyces cerevisiae anaerobic gene (ANB1) is negatively regulated both by oxygen and heme.	Oxygen	83-89	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	45-49
2231849-6	1990	Mean values for peak oxygen uptake were 48 +/- 7 ml kg-1 min-1 and 42 +/- 7 ml kg-1 min-1 in boys and girls respectively.	Oxygen	21-27	CD59 molecule (CD59 blood group)	Homo sapiens	57-89
2113607-7	1990	As with their reduction by xanthine oxidase and NADPH-cytochrome P450 reductase, the less negative the reductive potential of an antibiotic, the more it augmented oxygen consumption.	Oxygen	163-169	cytochrome p450 oxidoreductase	Homo sapiens	48-79
2344446-3	1990	Pretreatment of fibroblasts with liposome-encapsulated superoxide dismutase and catalase also conferred protection against the cytotoxic effects of 50% and 95% oxygen.	Oxygen	160-166	catalase	Rattus norvegicus	80-88
2140252-4	1990	Plasma immunoreactive ANF concentrations were 196 +/- 50 pg/ml during O2 breathing and were positively related to transmural pulmonary arterial wedge pressure (tPpaw, r = 0.90, p less than 0.001) and to PaCO2 (r = 0.57, p less than 0.02).	Oxygen	70-72	natriuretic peptide A	Homo sapiens	22-25
2350942-5	1990	With a reduction in arterial oxygen content of more than 20-25% the flow increase was sufficient to supply the heart with enough O2 during submaximal (heart rate 157 beats min-1) but not maximal exercise, in which case anaerobic glycolysis contributed significantly to the myocardial energy metabolism.	Oxygen	129-131	CD59 molecule (CD59 blood group)	Homo sapiens	172-177
2187628-2	1990	Recent research suggests that this tubular injury is caused by an imbalance of the oxygen supply and demand of medullary thick ascending limb (mTAL) tubular cells.	Oxygen	83-89	talipes	Mus musculus	143-147
2361782-8	1990	The difference between MAD activation of the soleus muscle and of the iliacus muscle, both consisting predominantly of type I fibers, suggests that MAD activity may be influenced by biochemical demand and oxygen supply, varying with the anatomical localization.	Oxygen	205-211	adenosine monophosphate deaminase 1	Rattus norvegicus	148-151
2109690-6	1990	In contrast, follicles cultured in 5% CO2 and 95% O2 responded to TNF with increased androstenedione and estradiol production.	Oxygen	39-41	tumor necrosis factor	Rattus norvegicus	66-69
2163431-4	1990	Elimination of O2 or interruption in blood flow caused, within 30-60 s, slight intracellular alkalinization followed by a small rise in [Ca2+]i, a mild degree of hyperpolarization, and disappearance of electrical activity in the cortex, in that order.	Oxygen	15-17	carbonic anhydrase 2	Rattus norvegicus	137-140
2158514-4	1990	In 8 of 10 patients studied, PMN capacity to oxidize intracellular dichlorofluorescein dye, an indirect measurement of O2- production in response to PMA stimulation, decreased after IL-2 administration (pre-IL-2 mean dichlorofluorescein oxidation (by channel number) 243 +/- 128 vs 3-day post-IL-2 87 +/- 86, p2 less than 0.02).	Oxygen	119-121	interleukin 2	Homo sapiens	182-186
2163431-8	1990	In the hippocampus area CA1 increases in [Ca2+]i to as much as 6-8 x 10(-4) were observed; some of these could be reversed when O2 or blood flow were restored to normal.	Oxygen	128-130	carbonic anhydrase 2	Rattus norvegicus	42-45
18592584-6	1990	Oxygen binding by the immobilized HbA is reversible and cooperative, with p50 values at 20 degrees C of 2.8, 6, and 24 mm Hg for the acacia- (pH 7.5), pectin- (pH 6.6), and dextransulfate-(pH 6.6) derived coacervates.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	74-77
2116678-6	1990	After training there were significant increases in mean maximal oxygen uptake (ml kg-1 min-1) from 23 (5) to 28 (6), oxygen pulse (ml/beat) from 8.8 (2.3) to 10.8 (2.4), and anaerobic threshold (1/min) from 1.11 (0.27) to 1.38 (0.33).	Oxygen	64-70	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
2158818-2	1990	The rates of adrenochrome reduction and the concomitant oxygen uptake are decreased in the presence of superoxide dismutase or catalase.	Oxygen	56-62	catalase	Homo sapiens	127-135
2185752-0	1990	Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung.	Oxygen	43-49	endothelin 1	Rattus norvegicus	0-12
18592584-8	1990	Oxygen binding by HbA incorporated into the stabilized coacervates derived from dextran sulfate is very similar to oxy gen binding by human red blood cells: p50 = 26 mm Hg and n = 1.89 at 37 degrees C in isotonic salt.	Oxygen	0-6	nuclear factor kappa B subunit 1	Homo sapiens	157-160
2188837-5	1990	Although alpha-adrenoceptor stimulation can result in coronary vasoconstriction and a fall in coronary blood flow in patients with heart failure due to underlying atheromatous coronary heart disease, increased myocardial oxygen demand as the result of beta 1 (and cardiac beta 2) simulation may be more relevant.	Oxygen	221-227	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	252-278
2157443-4	1990	These observations support the hypothesis that, in the micromolar concentration range, o-naphthoquinones inhibit microsomal lipid peroxidation and cytochrome P-450-catalyzed reactions, by diverting reducing equivalents from NADPH to dioxygen.	Oxygen	233-241	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	147-163
2112485-8	1990	By increasing filtration fraction and decreasing blood flow, AII decreases renal oxygen supply while maintaining oxygen consumption for solute reabsorption.	Oxygen	81-87	angiotensinogen	Rattus norvegicus	61-64
2112485-8	1990	By increasing filtration fraction and decreasing blood flow, AII decreases renal oxygen supply while maintaining oxygen consumption for solute reabsorption.	Oxygen	113-119	angiotensinogen	Rattus norvegicus	61-64
2125671-6	1990	Results of recent studies suggest that DT-diaphorase prevents formation of active oxygen species.	Oxygen	82-88	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	39-52
2156895-9	1990	NECA significantly increased association of [3H]FMLP with cytoskeletal preparations as it inhibited O2-.	Oxygen	100-102	formyl peptide receptor 1	Homo sapiens	48-52
2155963-10	1990	These results suggest that MDNCF/IL-8 induced antifungal action of PMN via oxygen-independent pathways.	Oxygen	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
2355823-8	1990	However, mean performance run oxygen uptake was significantly lower (3.87 +/- 0.3 to 3.80 +/- 0.3 l.min-1) with phosphate ingestion.	Oxygen	30-36	CD59 molecule (CD59 blood group)	Homo sapiens	100-105
2371578-2	1990	Oxygen, at 8 litres min-1, was delivered through a facemask via a circle absorber with a 2 litre reservoir bag.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	20-25
2327964-2	1990	Noradrenaline, vasopressin or angiotensin II further increased the release of these substances 2-5-fold, coinciding with increases in both perfusion pressure (vasoconstriction) and O2 uptake.	Oxygen	181-183	arginine vasopressin	Rattus norvegicus	15-26
2327964-2	1990	Noradrenaline, vasopressin or angiotensin II further increased the release of these substances 2-5-fold, coinciding with increases in both perfusion pressure (vasoconstriction) and O2 uptake.	Oxygen	181-183	angiotensinogen	Rattus norvegicus	30-44
1692236-5	1990	Among all the organophosphates tested, the combination of a methyl group and a negatively charged oxygen attached to the P atom, CH3P(O)(O-)-AChE, conferred the greatest protection to the active site of aged or nonaged organophosphoryl conjugates of acetylcholinesterase.	Oxygen	98-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	250-270
2155963-10	1990	These results suggest that MDNCF/IL-8 induced antifungal action of PMN via oxygen-independent pathways.	Oxygen	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
2109626-4	1990	The mean value for oxygen consumption was 3.25 ml kg-1 min-1, declining by 8% during the 2 h of anaesthesia.	Oxygen	19-25	CD59 molecule (CD59 blood group)	Homo sapiens	55-60
2185764-4	1990	Plasma fibrinogen, as the major contributing factor to plasma viscosity and red-blood-cell aggregation can limit oxygen supply and blood flow in microcirculation even in the absence of apparent coronary artery disease.	Oxygen	113-119	fibrinogen beta chain	Homo sapiens	7-17
2306490-3	1990	Shifts in the ligand affinity of deoxy Hb and the values for 50% ligand saturation (p50) were obtained from oxygen equilibrium data.	Oxygen	108-114	nuclear factor kappa B subunit 1	Homo sapiens	84-87
2116154-1	1990	Functional parameters of the whole blood oxygen loading from 66 anemic subjects, compared with those from 66 normal adult of both sexes display the following behaviour: a) Adult males and females differ for p50 values, which are higher in females because of their lower Hb level.	Oxygen	41-47	nuclear factor kappa B subunit 1	Homo sapiens	207-210
2341345-4	1990	This protection against O2 toxicity by TNF insufflation was associated with increased lung superoxide dismutase, catalase, and glutathione peroxidase activities.	Oxygen	24-26	catalase	Rattus norvegicus	113-121
1969783-7	1990	The undesirable effects of beta 1 full agonists, such as tachycardia, arrhythmias, increased myocardial oxygen consumption, and effects on the peripheral vasculature, are not seen with xamoterol.	Oxygen	104-110	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	27-33
2347031-0	1990	Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2(+)-ascorbic acid-O2 system.	Oxygen	134-136	arachidonate 5-lipoxygenase	Homo sapiens	11-25
2107137-3	1990	Oxygen consumption (ml/min/1.73 m2) in normal subjects, in patients with acute hepatitis and in patients with cirrhosis was 206.5 +/- 4.0 (mean +/- S.E.M.	Oxygen	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	23-28
2306804-0	1990	Role of oxygen-derived free radicals in acute angiotensin II--induced hypertensive vascular disease in the rat.	Oxygen	8-14	angiotensinogen	Rattus norvegicus	46-60
2303284-9	1990	These data suggest that recombinant human erythropoietin administration suppressed the hyperdynamic cardiac state that was required to maintain oxygen delivery to the peripheral tissues in severe uremic anemia.	Oxygen	144-150	erythropoietin	Homo sapiens	42-56
2306117-10	1990	These and other results suggested that the superoxide radical and/or its metabolite(s) might play an important role in the pathogenesis of the reflow-induced liver injury and that SM-SOD might be useful for studying the mechanism for tissue injury caused by oxygen toxicity.	Oxygen	258-264	superoxide dismutase 1	Homo sapiens	183-186
2330456-5	1990	Positive correlations were observed between the levels of arterial oxygen pressures (PaO2) and the GSH concentrations, the activities of GPX and SOD, respectively.	Oxygen	67-73	superoxide dismutase 1	Homo sapiens	145-148
2404746-9	1990	On the other hand, islets cultured with IL-6 (5000 pg/ml) exhibited an elevated glucose oxidation and oxygen uptake, but a lower ATP content at 16.7 mM glucose and an unaffected glucose utilization and glutamine oxidation compared to the controls.	Oxygen	102-108	interleukin 6	Rattus norvegicus	40-44
2306475-8	1990	These findings are consistent with a uni-uni-ping-pong-ter-bi kinetic mechanism for dopamine beta-hydroxylase that involves a ternary enzyme-ascorbate-tyramine-oxygen complex.	Oxygen	160-166	dopamine beta-hydroxylase	Bos taurus	84-109
2336490-3	1990	At pH 7.4 the P50 (partial pressure of O2 at 50% hemoglobin saturation) +/- SEM values were 22.4 +/- 0.6,25.3 +/- 0.5, and 28.5 +/- 0.4 Torr at 33, 37 and 41 degrees C, respectively.	Oxygen	39-41	nuclear factor kappa B subunit 1	Homo sapiens	14-17
2153711-6	1990	This result suggests that IFN-gamma-induced growth inhibition and production of cytocidal oxygen intermediates are mediated via a common pathway.	Oxygen	90-96	interferon gamma	Mus musculus	26-35
1689417-8	1990	These data suggest that in patients with stable-effort angina, ACE inhibition with cilazapril is able to redistribute myocardial blood flow and to improve regional oxygen supply to the ischemic myocardium.	Oxygen	164-170	angiotensin I converting enzyme	Homo sapiens	63-66
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	tumor necrosis factor	Homo sapiens	38-65
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	tumor necrosis factor	Homo sapiens	67-76
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	superoxide dismutase 1	Homo sapiens	184-187
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	cytochrome c, somatic	Homo sapiens	213-225
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	tumor necrosis factor	Homo sapiens	371-380
2295300-3	1990	Fibrinogen elimination reduced plasma viscosity by 13-14% and clearly raised the transcutaneously measured partial pressure of oxygen by 33-50%.	Oxygen	127-133	fibrinogen beta chain	Homo sapiens	0-10
2248437-10	1990	On the other hand, MCI-186 was found to have a complete quenching activity to the chemiluminescence due to active oxygens in the TPA-leukocyte system.	Oxygen	114-121	plasminogen activator, tissue type	Homo sapiens	129-132
2153352-4	1990	O2- release was evaluated using a superoxide dismutase (SOD)-inhibitable lucigenin-dependent chemiluminescence method.	Oxygen	0-2	superoxide dismutase 1	Homo sapiens	34-54
2153352-4	1990	O2- release was evaluated using a superoxide dismutase (SOD)-inhibitable lucigenin-dependent chemiluminescence method.	Oxygen	0-2	superoxide dismutase 1	Homo sapiens	56-59
1965118-1	1990	Neutrophil myeloperoxidase is an important component of the oxygen-dependent microbicidal system and is enzymatically activated in crevicular cells.	Oxygen	60-66	myeloperoxidase	Homo sapiens	11-26
2158297-8	1990	It is suggested that oxygen free radicals may influence Ca2+ movements in the cell by altering the Ca2+/Mg2+ ATPase and Ca2(+)-binding activities of the membrane and these effects may be oxygen-radical species specific.	Oxygen	21-27	carbonic anhydrase 2	Rattus norvegicus	56-59
2141255-3	1990	We have demonstrated that a mixture of oxygen metabolite scavengers containing mannitol, superoxide dismutase and catalase included in the perfusion medium significantly reduced protein excretion.	Oxygen	39-45	catalase	Rattus norvegicus	114-122
2242448-4	1990	Investigation of the molecular mechanism of action of molsidomine/SIN-1 indicate that molecular oxygen initiates NO formation through a one-electron abstraction from the intermediate.	Oxygen	96-102	MAPK associated protein 1	Homo sapiens	66-71
1690029-6	1990	When a HbO2 curve was established based on a large volume of blood consisting of adult blood and newborn cord blood mixed to attain a P50 of 25.1 mm Hg, the PaO2 at 90% O2 saturation was 52 mm Hg.	Oxygen	9-11	nuclear factor kappa B subunit 1	Homo sapiens	134-137
2386518-0	1990	Influence of erythropoietin treatment on 2,3-bisphosphoglycerate and O2-affinity of red blood cells in children with renal anemia.	Oxygen	69-71	erythropoietin	Homo sapiens	13-27
2386518-4	1990	Thus improvement of renal anemia by stimulation of erythropoiesis by means of EPO was accompanied by a decreased O2-affinity of hemoglobin and therefore by an additionally improved O2-supply to the tissues.	Oxygen	113-115	erythropoietin	Homo sapiens	78-81
2386518-4	1990	Thus improvement of renal anemia by stimulation of erythropoiesis by means of EPO was accompanied by a decreased O2-affinity of hemoglobin and therefore by an additionally improved O2-supply to the tissues.	Oxygen	181-183	erythropoietin	Homo sapiens	78-81
2158297-8	1990	It is suggested that oxygen free radicals may influence Ca2+ movements in the cell by altering the Ca2+/Mg2+ ATPase and Ca2(+)-binding activities of the membrane and these effects may be oxygen-radical species specific.	Oxygen	21-27	carbonic anhydrase 2	Rattus norvegicus	99-102
2158297-8	1990	It is suggested that oxygen free radicals may influence Ca2+ movements in the cell by altering the Ca2+/Mg2+ ATPase and Ca2(+)-binding activities of the membrane and these effects may be oxygen-radical species specific.	Oxygen	21-27	carbonic anhydrase 2	Rattus norvegicus	99-102
2171573-7	1990	At ambient oxygen concentration the orders of the current with respect to the concentration of cytochrome oxidase, cytochrome c and oxygen are found to be 1/2, 1/2 and zero respectively.	Oxygen	11-17	cytochrome c, somatic	Homo sapiens	115-127
2168295-6	1990	Superoxide dismutase (SOD) inhibits both thiol oxidation and oxygen consumption as well as oxidation of NAD(P)H if present in the mixture.	Oxygen	61-67	superoxide dismutase 1	Homo sapiens	0-20
2101061-4	1990	Mean maximum oxygen consumption (VO2max) was 61.21 +/- 5.36 ml kg-1 min-1.	Oxygen	13-19	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
2403855-3	1990	The reaction required an NADPH-generating system and molecular oxygen and was inhibited by carbon monoxide, suggesting that a cytochrome P450-linked mono-oxygenase system is prerequisite for the deactivation reaction.	Oxygen	63-69	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	126-141
2168295-6	1990	Superoxide dismutase (SOD) inhibits both thiol oxidation and oxygen consumption as well as oxidation of NAD(P)H if present in the mixture.	Oxygen	61-67	superoxide dismutase 1	Homo sapiens	22-25
2379326-2	1990	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) catalyze enzymatic reactions to remove oxidant stresses, particularly O2- and H2O2.	Oxygen	150-152	catalase	Mus musculus	28-36
2090377-4	1990	Catalase effects the breakdown of H2O2 to O2 and H2O and offers protection against the toxic effects of oxygen radicals.	Oxygen	36-38	catalase	Mus musculus	0-8
2379326-2	1990	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) catalyze enzymatic reactions to remove oxidant stresses, particularly O2- and H2O2.	Oxygen	150-152	catalase	Mus musculus	38-41
2347318-4	1990	After the fifth stage, peak oxygen consumption was determined by having the subject work against a resistance of 14.7-19.6 N at 30 rev.min-1.	Oxygen	28-34	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
2276339-5	1990	The Kcat/KM values, which indicate the efficiency of enzyme catalysis, for NADPH plus O2-, t-BuOOH, and CumOOH-dependent aniline hydroxylase from EtOH-fed rats were 102, 37, and 5 and from pair-fed rats were 68, 4, and 4 (nmol p-aminophenol/min/nmol cytochrome P-450)/mM aniline, respectively.	Oxygen	86-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	250-266
2335163-12	1990	The highest oxygen consumption seen was 2.08 l min-1 and maximum minute ventilation was 641.	Oxygen	12-18	CD59 molecule (CD59 blood group)	Homo sapiens	47-52
2113029-3	1990	DT-diaphorase-reduced adrenochrome undergoes autoxidation as shown by the oxygen uptake occurring during the reaction.	Oxygen	74-80	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	0-13
2323698-3	1990	After injection of hydrogen peroxide into the human bulb, the microvasculature was filled with oxygen produced by endothelial catalase and visualized after embedding in a mixture of cedar oil and gum damar.	Oxygen	95-101	catalase	Homo sapiens	126-134
2158476-2	1990	The primary radical produced was O2- as determined by ESR spin trapping and cytochrome c reduction.	Oxygen	33-35	cytochrome c, somatic	Homo sapiens	76-88
2175283-5	1990	Superoxide dismutase and catalase decreased the rate of oxygen consumption, thus demonstrating the production of superoxide and hydrogen peroxide, respectively.	Oxygen	56-62	catalase	Homo sapiens	25-33
2276598-0	1990	A comparison of vasopressin and noradrenaline on oxygen uptake by perfused rat hindlimb, kidney, intestine and mesenteric arcade suggests that it is in part due to contractile work by blood vessels.	Oxygen	49-55	arginine vasopressin	Rattus norvegicus	16-27
2276598-4	1990	Both vasopressin (K0.5 = 0.1 nM) and noradrenaline (K0.5 = 2 nM) increased oxygen uptake as well as perfusion pressure by the perfused hindlimb; changes in oxygen uptake were closely matched by changes in pressure.	Oxygen	75-81	arginine vasopressin	Rattus norvegicus	5-16
2298385-2	1990	The effect of noradrenaline as well as of vasopressin and angiotensin II to increase oxygen uptake and perfusion pressure by the isolated perfused rat hindlimb were completely inhibited by the vasodilators, nitroprusside (0.5 mM), nifedipine (2.5 microM) and isoprenaline (50 nM).	Oxygen	85-91	arginine vasopressin	Rattus norvegicus	42-53
2298385-2	1990	The effect of noradrenaline as well as of vasopressin and angiotensin II to increase oxygen uptake and perfusion pressure by the isolated perfused rat hindlimb were completely inhibited by the vasodilators, nitroprusside (0.5 mM), nifedipine (2.5 microM) and isoprenaline (50 nM).	Oxygen	85-91	angiotensinogen	Rattus norvegicus	58-72
2298385-4	1990	Oxygen uptake due to sciatic nerve stimulation of skeletal muscle contraction was not inhibited by 0.5 mM nitroprusside but was found to increase further that produced by a maximum dose of either noradrenaline or angiotensin II.	Oxygen	0-6	angiotensinogen	Rattus norvegicus	213-227
2276598-4	1990	Both vasopressin (K0.5 = 0.1 nM) and noradrenaline (K0.5 = 2 nM) increased oxygen uptake as well as perfusion pressure by the perfused hindlimb; changes in oxygen uptake were closely matched by changes in pressure.	Oxygen	156-162	arginine vasopressin	Rattus norvegicus	5-16
2276598-8	1990	The perfused kidney also responded to vasopressin and noradrenaline with parallel increases in oxygen uptake and perfusion pressure for each agent.	Oxygen	95-101	arginine vasopressin	Rattus norvegicus	38-49
2276598-12	1990	Vasopressin increased oxygen uptake and pressure by the perfused intestine over the range 0.01-2 nM, but the changes in pressure only became significant at doses greater than 0.1 nM.	Oxygen	22-28	arginine vasopressin	Rattus norvegicus	0-11
2276598-19	1990	Vasopressin (K0.5 = 0.3 nM) and noradrenaline (K0.5 = 30 nM) each increased oxygen uptake and perfusion pressure in a dose-dependent manner.	Oxygen	76-82	arginine vasopressin	Rattus norvegicus	0-11
2312480-12	1990	Toxic O2 metabolites were involved in the injury because addition of erythrocytes or catalase to the perfusate attenuated the injury.	Oxygen	6-8	catalase	Rattus norvegicus	85-93
1966131-3	1990	At 20-50 times the optimal chemotactic concentration some O2- and H2O2 production was observed with f-Met-Leu-Phe, C5a and LTB4, but not with MOC/IL-8.	Oxygen	58-60	complement C5a receptor 1	Homo sapiens	115-118
2201820-1	1990	The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin.	Oxygen	100-106	erythropoietin	Homo sapiens	171-185
2153208-5	1990	It is observed that optimal mu/kappa-receptor selectivity is obtained when the oxygen atom of the methyl ether or the tetrahydrofuran ring is joined to the equatorial C-4 position.	Oxygen	79-85	complement C4A	Rattus norvegicus	167-170
2167416-6	1990	These findings support the idea that O2 sensitive hemoproteins of the microsomal mixed-functional oxidases play a role in the control of the synthesis of Epo.	Oxygen	37-39	erythropoietin	Homo sapiens	154-157
2076828-1	1990	Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls.	Oxygen	170-176	superoxide dismutase 1	Homo sapiens	0-26
2076828-1	1990	Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls.	Oxygen	170-176	superoxide dismutase 1	Homo sapiens	28-37
2076828-1	1990	Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls.	Oxygen	170-176	catalase	Homo sapiens	73-81
2162582-2	1990	To exemplify the first-group reactions, cytochrome P-450 was studied, which is capable of generating different active forms of oxygen during the catalytic cycle.	Oxygen	127-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-56
2304981-2	1990	The triplet excited states of the various macrocyclic dyes generate singlet molecular oxygen, O2(1 delta g) in high quantum yield upon illumination in O2-saturated solution, even in the presence of HSA.	Oxygen	86-92	albumin	Homo sapiens	198-201
2075374-2	1990	With relevance to rheumatoid arthritis (RA) IL-1 augments release of prostanoids, proteinases and oxygen metabolites and is a potent inducer of bone and cartilage resorption.	Oxygen	98-104	interleukin 1 beta	Homo sapiens	44-48
2089606-5	1990	The acute changes in calculated p50 are in agreement with the effect of hyperventilation on oxygen status.	Oxygen	92-98	nuclear factor kappa B subunit 1	Homo sapiens	32-35
2089607-1	1990	The influences of analytical variation of sO2 and pO2 measurements on the oxygen parameters p50, pO2uv-, DavO2c, CQ are examined by simulation.	Oxygen	74-80	nuclear factor kappa B subunit 1	Homo sapiens	92-95
2089610-2	1990	The P50 was calculated from a single measurement of oxygen tension and hemoglobin saturation in blood obtained from the pulmonary artery or the venous line from the cardiopulmonary bypass circuit.	Oxygen	52-58	nuclear factor kappa B subunit 1	Homo sapiens	4-7
2089616-6	1990	Interpretation of p50 is discussed in relation to evaluation of patients with hemoglobinopathies and as a parameter in estimating availability of oxygen to the tissues.	Oxygen	146-152	nuclear factor kappa B subunit 1	Homo sapiens	18-21
2651385-5	1989	Insulin-stimulated O2 uptake and maximal glucose oxidation rate were higher in T than in UT and UT-ex.	Oxygen	19-21	insulin	Homo sapiens	0-7
2259891-3	1990	We investigated the possibility that oxygen inhibits the test by blocking B27, but we were unable to obtain consistent positive results.	Oxygen	37-43	melanocortin 2 receptor accessory protein	Homo sapiens	74-77
2353187-3	1990	A negative correlation was found for CK-BB concentration and arterial oxygen saturation (r = -0.41, p less than 0.02 for all children and r = -0.62, p less than 0.05 for those with tetralogy of Fallot).	Oxygen	70-76	creatine kinase B	Homo sapiens	37-42
2401169-6	1990	The difference of arterio-venous VIP content increased from -3 +/- 6 pg/ml before hypoxia to +9 +/- 7 pg/ml after inhalation of 10% oxygen for 30 minutes.	Oxygen	132-138	vasoactive intestinal peptide	Canis lupus familiaris	33-36
2162582-4	1990	In the course of the reaction, cytochrome P-450 also became inactivated under the effect of active oxygen.	Oxygen	99-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
2162582-7	1990	The second reaction group was exemplified by human leucocyte myeloperoxidase which generated hypochlorite along with the active forms of oxygen.	Oxygen	137-143	myeloperoxidase	Homo sapiens	61-76
2162582-9	1990	The Ames test revealed mutagenic effects of the active oxygen forms generated by myeloperoxidase.	Oxygen	55-61	myeloperoxidase	Homo sapiens	81-96
33772551-7	2021	More important, PPARgamma has been shown to affect host-microbiota interactions by modulating the energy metabolism of colonocytes and the oxygen availability of the intestinal microbiome.	Oxygen	139-145	peroxisome proliferator activated receptor gamma	Homo sapiens	16-25
33971543-5	2021	LPS increased cytoplasmic and mitochondrial reactive oxygen species resulting in CFTR carbonylation.	Oxygen	53-59	CF transmembrane conductance regulator	Homo sapiens	81-85
33973103-2	2021	Hypoxia culture or CoCl2 induced-oxygen deprivation condition could promote SKOV3 cells to express cyclooxygenase-2 (COX2).	Oxygen	33-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	99-115
33973103-2	2021	Hypoxia culture or CoCl2 induced-oxygen deprivation condition could promote SKOV3 cells to express cyclooxygenase-2 (COX2).	Oxygen	33-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	117-121
33803109-2	2021	Brain mitochondria of homozygous knock-in mutant Mrps5V338Y/V338Y mice show decreased oxygen consumption and reduced ATP levels.	Oxygen	86-92	mitochondrial ribosomal protein S5	Mus musculus	49-54
33823923-8	2021	Patients with CTD-CPFE had a higher frequency of pulmonary hypertension and pulmonary fibrosis > 20% of the total lung volume, higher ratio of the forced vital capacity to the diffusion capacity of the lung for carbon monoxide (DLCO), lower arterial oxygen pressure at rest, and lower DLCO compared to those in patients with CTD-ILD without emphysema.	Oxygen	250-256	CTD	Homo sapiens	14-17
33816593-6	2021	An ER-located protein Ero1 is known to directly consume molecular oxygen to initiate the ER protein oxidation cascade, which promotes oxidative protein folding of ER client proteins.	Oxygen	66-72	ER oxidoreductin	Saccharomyces cerevisiae S288C	22-26
33816593-7	2021	Our further study using ero1-mutant strains suggested that, in addition to mitochondrial respiration, this Ero1-medaited reaction contributes to mitigation of ER stress by molecular oxygen.	Oxygen	182-188	ER oxidoreductin	Saccharomyces cerevisiae S288C	24-28
33816593-7	2021	Our further study using ero1-mutant strains suggested that, in addition to mitochondrial respiration, this Ero1-medaited reaction contributes to mitigation of ER stress by molecular oxygen.	Oxygen	182-188	ER oxidoreductin	Saccharomyces cerevisiae S288C	107-111
33805516-4	2021	We previously showed that superoxide dismutase 1 (SOD1) loss induced various aging-like pathologies via oxidative damage due to the accumulation of O2 - in mice.	Oxygen	148-152	superoxide dismutase 1, soluble	Mus musculus	26-48
33805516-4	2021	We previously showed that superoxide dismutase 1 (SOD1) loss induced various aging-like pathologies via oxidative damage due to the accumulation of O2 - in mice.	Oxygen	148-152	superoxide dismutase 1, soluble	Mus musculus	50-54
33805516-5	2021	However, the pathological contribution of XO-derived O2 - production to aging-like tissue damage induced by SOD1 loss remains unclear.	Oxygen	53-57	superoxide dismutase 1, soluble	Mus musculus	108-112
33774721-0	2021	Does hypoxia-inducible factor 1alpha play a role in regulating cutaneous oxygen flux in larval zebrafish (Danio rerio)?	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha a	Danio rerio	5-36
33809716-1	2021	Superoxide dismutase (SOD) is an enzyme that catalyzes the dismutation of two superoxide anions (O2 -) into hydrogen peroxide (H2O2) and oxygen (O2) and is generally known to protect against oxidative stress.	Oxygen	97-101	superoxide dismutase 1, soluble	Mus musculus	22-25
33809716-1	2021	Superoxide dismutase (SOD) is an enzyme that catalyzes the dismutation of two superoxide anions (O2 -) into hydrogen peroxide (H2O2) and oxygen (O2) and is generally known to protect against oxidative stress.	Oxygen	137-143	superoxide dismutase 1, soluble	Mus musculus	22-25
33809716-1	2021	Superoxide dismutase (SOD) is an enzyme that catalyzes the dismutation of two superoxide anions (O2 -) into hydrogen peroxide (H2O2) and oxygen (O2) and is generally known to protect against oxidative stress.	Oxygen	97-99	superoxide dismutase 1, soluble	Mus musculus	22-25
33803239-6	2021	Additionally, apelin inhibited caspase 3 and 7 activity and DNA fragmentation in staurosporine-induced apoptosis as also attenuated oxidative stress by increasing extracellular oxygen consumption.	Oxygen	177-183	apelin	Homo sapiens	14-20
33761740-8	2021	The absence of denaturation is further confirmed in situ by the absence of electrocatalytic activity toward O2 (observed in the case of Cyt c denaturation).	Oxygen	108-110	cytochrome c, somatic	Homo sapiens	136-141
33819482-8	2021	FACS analyses, together with oxygen consumption, sphere formation, and tumorigenicity assays all indicated that Bcl3 loss resulted in CSC compartment expansion promoting cellular dedifferentiation.	Oxygen	29-35	B cell leukemia/lymphoma 3	Mus musculus	112-116
33812256-0	2021	Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.	Oxygen	32-38	kelch like ECH associated protein 1	Homo sapiens	179-184
33812256-0	2021	Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.	Oxygen	32-38	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
33781216-8	2021	We analyzed the association between the IL-6 at the initial assessment and development of hypoxemia during follow up and determined the cut-off of the IL-6 able to predict the development of hypoxemia requiring oxygen therapy.	Oxygen	211-217	interleukin 6	Homo sapiens	151-155
33806765-3	2021	Hypoxia (1% O2) significantly and time-dependently increased the expression of hypoxia-inducible factor (HIF)-1alpha and fibrotic marker proteins collagen I and III (COL1A and COL3A), transforming growth factor (TGF)-beta1 and alpha-smooth muscle actin (SMA).	Oxygen	12-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-116
33806765-3	2021	Hypoxia (1% O2) significantly and time-dependently increased the expression of hypoxia-inducible factor (HIF)-1alpha and fibrotic marker proteins collagen I and III (COL1A and COL3A), transforming growth factor (TGF)-beta1 and alpha-smooth muscle actin (SMA).	Oxygen	12-14	transforming growth factor beta 1	Homo sapiens	184-222
33824698-9	2021	Sustained IL-6 stimulation increased intracellular reactive oxygen species, repressed mitochondrial membrane potential (MMP), decreased intracellular content of ATP, and led to decreased SOD activity, an increase in iNOS protein expression, and increased protein expression of Pink1, Parkin, and Bnip3 involving in mitophagy, all of which were reversed by raloxifene.	Oxygen	60-66	interleukin 6	Mus musculus	10-14
33815657-9	2021	In vitro, L-Arginine induced the expression of a key regulator of mitochondrial biogenesis (PGC1alpha) and genes encoding for complex I and increased the production of nitric oxide and the maximal oxygen consumption rate.	Oxygen	197-203	PPARG coactivator 1 alpha	Homo sapiens	92-101
33763142-9	2021	In addition, we demonstrated that the 25 muM Cu2+ was similar to 1% oxygen environment in terms of the effectiveness of activating the HIF-1alpha signaling pathway.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-145
33236899-2	2021	The reaction is initiated by solar light or the blue LED activation of 9,10-dibromoanthracene in a reaction with oxygen and takes place at ambient temperature and air pressure.	Oxygen	113-119	small integral membrane protein 10 like 2A	Homo sapiens	53-56
33236504-6	2021	The locally restrained TCPP-CAT not only produces ROS under ultrasonic treatment, but also sustainably reverses the oxygen-deficient status in solid tumors by triggering the O2 generation from the decomposition of endogenous H2 O2 , further promoting the efficacy of SDT.	Oxygen	116-122	catalase	Homo sapiens	28-31
33236504-6	2021	The locally restrained TCPP-CAT not only produces ROS under ultrasonic treatment, but also sustainably reverses the oxygen-deficient status in solid tumors by triggering the O2 generation from the decomposition of endogenous H2 O2 , further promoting the efficacy of SDT.	Oxygen	174-176	catalase	Homo sapiens	28-31
33031018-1	2020	Ingestion of dietary nitrate (NO3-) is associated with improved exercise tolerance and reduced oxygen (O2) cost of exercise, ascribed to enhanced mitochondrial efficiency, muscle contractile function or other factors.	Oxygen	95-101	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
33031018-1	2020	Ingestion of dietary nitrate (NO3-) is associated with improved exercise tolerance and reduced oxygen (O2) cost of exercise, ascribed to enhanced mitochondrial efficiency, muscle contractile function or other factors.	Oxygen	103-105	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	81-83	catalase	Homo sapiens	201-204
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	catalase	Homo sapiens	201-204
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	catalase	Homo sapiens	201-204
32796124-7	2020	The loss of FAD5 in the crl mutant might attenuate the levels of RES and/or lipid peroxidation due to the reduced levels of palmitic acid-driven PUFAs, which are prime targets of reactive oxygen species.	Oxygen	188-194	crumpled leaf	Arabidopsis thaliana	24-27
29458318-0	2018	Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX).	Oxygen	120-126	MAX network transcriptional repressor	Homo sapiens	140-143
29458318-2	2018	OBJECTIVE: To describe the study protocol and statistical analysis plan for the ICU randomised trial comparing two approaches to oxygen therapy (ICU-ROX).	Oxygen	129-135	MAX network transcriptional repressor	Homo sapiens	149-152
29458318-10	2018	RESULTS AND CONCLUSIONS: ICU-ROX will compare the effect of conservative v standard oxygen therapy in critically ill mechanically ventilated adults who are expected to be ventilated beyond the day after recruitment on ventilatorfree days to Day 28.	Oxygen	84-90	MAX network transcriptional repressor	Homo sapiens	29-32
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-81
28179905-8	2017	MIF and DDT levels correlated with concentrations of vascular endothelial growth factor, a protein upregulated under low oxygen tension and implicated in vascular and lung development (R = 0.70, P &lt; 0.0001 for MIF and R = 0.65, P &lt; 0.0001 for DDT).	Oxygen	121-127	vascular endothelial growth factor A	Homo sapiens	53-87
26997627-4	2016	The oxygen-sensing PHDs regulate the stability of hypoxia-inducible factor 1alpha (HIF1alpha) as well as other proline-containing proteins by catalyzing the hydroxylation of proline residues.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-92
25420773-8	2014	Our findings reveal that PHD3 inactivation provides an alternative route of EGFR activation through which tumour cells sustain proliferative signalling even under conditions of limited oxygen availability.	Oxygen	185-191	epidermal growth factor receptor	Homo sapiens	76-80
26053282-7	2015	Consistent with the phenotype, EGLN1 in Tibetans has a gain-of-function mutation that confers a higher affinity for oxygen, hence less sensitivity to hypoxia.	Oxygen	116-122	egl-9 family hypoxia inducible factor 1	Homo sapiens	31-36
26640566-11	2015	The treatment of human LECs with 0 and 20% atmospheric O2 activated Nrf2/Keap1.	Oxygen	55-57	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
26640566-11	2015	The treatment of human LECs with 0 and 20% atmospheric O2 activated Nrf2/Keap1.	Oxygen	55-57	kelch like ECH associated protein 1	Homo sapiens	73-78
26640566-12	2015	The LECs shifted to 1% atmospheric O2 from 0, 4 or 20% for 24 h showed decreased levels of Keap1.	Oxygen	35-37	kelch like ECH associated protein 1	Homo sapiens	91-96
26640566-13	2015	By contrast, hLECs cultured in 1% atmospheric O2 for 24 h and then shifted to 0, 4 or 20% O2 exhibited a significant upregulation of Nrf2.	Oxygen	46-48	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
26640566-13	2015	By contrast, hLECs cultured in 1% atmospheric O2 for 24 h and then shifted to 0, 4 or 20% O2 exhibited a significant upregulation of Nrf2.	Oxygen	90-92	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
26640566-17	2015	Either 0 or 20% of atmospheric O2 activated the UPR and the Nrf2/Keap1-mediated antioxidant system in LECs and chronic exposure to O2 fluctuation led to ROS production and cell death.	Oxygen	31-33	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
26640566-17	2015	Either 0 or 20% of atmospheric O2 activated the UPR and the Nrf2/Keap1-mediated antioxidant system in LECs and chronic exposure to O2 fluctuation led to ROS production and cell death.	Oxygen	31-33	kelch like ECH associated protein 1	Homo sapiens	65-70
26640566-17	2015	Either 0 or 20% of atmospheric O2 activated the UPR and the Nrf2/Keap1-mediated antioxidant system in LECs and chronic exposure to O2 fluctuation led to ROS production and cell death.	Oxygen	131-133	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
26640566-17	2015	Either 0 or 20% of atmospheric O2 activated the UPR and the Nrf2/Keap1-mediated antioxidant system in LECs and chronic exposure to O2 fluctuation led to ROS production and cell death.	Oxygen	131-133	kelch like ECH associated protein 1	Homo sapiens	65-70
25594695-9	2015	The data shown here support the notion that excess I- inhibits NIS at the cell surface at early times by means of a posttranslational mechanism that involves reactive derived oxygen species.	Oxygen	175-181	solute carrier family 5 member 5	Rattus norvegicus	63-66
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	Oxygen	77-85	cystathionine beta-synthase	Homo sapiens	60-63
19900406-1	2010	Upregulated gene 11 (URG11), recently identified as a new HBx-upregulated gene that may activate beta-catenin and Wnt signaling, was found to be upregulated in a human tubule cell line under low oxygen.	Oxygen	195-201	von Willebrand factor C and EGF domains	Homo sapiens	0-19
19900406-1	2010	Upregulated gene 11 (URG11), recently identified as a new HBx-upregulated gene that may activate beta-catenin and Wnt signaling, was found to be upregulated in a human tubule cell line under low oxygen.	Oxygen	195-201	von Willebrand factor C and EGF domains	Homo sapiens	21-26
18278872-0	2008	Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.	Oxygen	0-8	cystathionine beta-synthase	Homo sapiens	64-91
21345980-7	2011	RESULTS: RES incubation under 40% oxygen increased the expression of FoxO1A, FoxO3A, and FoxO4.	Oxygen	34-40	forkhead box O1	Homo sapiens	69-75
21345980-7	2011	RESULTS: RES incubation under 40% oxygen increased the expression of FoxO1A, FoxO3A, and FoxO4.	Oxygen	34-40	forkhead box O3	Homo sapiens	77-83
21364630-7	2010	Western blotting revealed significantly upregulated oxygen-sensitive transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, while producing a biphasic response within HIF targets, including erythropoietin, vascular endothelial growth factor and Bcl-2 family members, during hypoxia and subsequent reoxygenation.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-128
21364630-7	2010	Western blotting revealed significantly upregulated oxygen-sensitive transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, while producing a biphasic response within HIF targets, including erythropoietin, vascular endothelial growth factor and Bcl-2 family members, during hypoxia and subsequent reoxygenation.	Oxygen	52-58	erythropoietin	Homo sapiens	211-225
21364630-7	2010	Western blotting revealed significantly upregulated oxygen-sensitive transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, while producing a biphasic response within HIF targets, including erythropoietin, vascular endothelial growth factor and Bcl-2 family members, during hypoxia and subsequent reoxygenation.	Oxygen	52-58	vascular endothelial growth factor A	Homo sapiens	227-261
21364630-7	2010	Western blotting revealed significantly upregulated oxygen-sensitive transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, while producing a biphasic response within HIF targets, including erythropoietin, vascular endothelial growth factor and Bcl-2 family members, during hypoxia and subsequent reoxygenation.	Oxygen	52-58	BCL2 apoptosis regulator	Homo sapiens	266-271
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	Oxygen	77-85	cystathionine beta-synthase	Homo sapiens	102-105
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	72-80	cystathionine beta-synthase	Homo sapiens	59-62
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	72-80	cystathionine beta-synthase	Homo sapiens	251-254
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	260-268	cystathionine beta-synthase	Homo sapiens	59-62
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	260-268	cystathionine beta-synthase	Homo sapiens	251-254
9051297-15	1997	ZnPP (10 microM) curtailed the relaxant response of the oxygen (30%)/indomethacin (2.8 microM)-contracted ductus to bradykinin (35 nM), while it left the sodium nitroprusside (35 nM) relaxation unchanged.	Oxygen	56-62	kininogen 1	Homo sapiens	116-126
9110952-12	1996	These rates amount to approximately 1000 ml O2 kg-1 min-1.	Oxygen	44-46	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
1503677-4	1992	Drug oxidation by myeloperoxidase leads to free radical metabolite formation; these reactive free radicals can oxidise glutathione to a thiyl free radical, which in the presence of oxygen forms oxygen-derived free radicals.	Oxygen	181-187	myeloperoxidase	Homo sapiens	18-33
7843134-4	1994	An in vitro experiment indicated that DNA single-strand breaks by dimethylarsine were suppressed by the presence of superoxide dismutase and catalase, suggesting that the strand breaks were induced via the production of free-radical species including active oxygens.	Oxygen	258-265	catalase	Mus musculus	141-149
1503677-4	1992	Drug oxidation by myeloperoxidase leads to free radical metabolite formation; these reactive free radicals can oxidise glutathione to a thiyl free radical, which in the presence of oxygen forms oxygen-derived free radicals.	Oxygen	194-200	myeloperoxidase	Homo sapiens	18-33
34817267-7	2022	Our results show demonstrate that both mitochondrial respiration capacity and reactive oxygen species emission are altered with Fmr1 deletion in astrocytes and these changes were dependent upon both sexual dimorphism and oxygen availability.	Oxygen	221-227	fragile X messenger ribonucleoprotein 1	Homo sapiens	128-132
34838318-5	2022	Catalase can convert H2O2 into O2, increasing the concentration of oxygen around the cells and overcoming the problem of hypoxia in the tumour, which enhances the effects of PDT.	Oxygen	31-33	catalase	Homo sapiens	0-8
34838318-5	2022	Catalase can convert H2O2 into O2, increasing the concentration of oxygen around the cells and overcoming the problem of hypoxia in the tumour, which enhances the effects of PDT.	Oxygen	67-73	catalase	Homo sapiens	0-8
34749258-6	2022	The in-situ time-dependent ATR-FTIR spectra provide evidence of water bonding to: the mu-OH group, the carboxylate anion COO- in 2,5-FDCA2- linker, oxygen atom in the furan ring of the linker, and the C-C and C-H bonds of the furan ring of the linker.	Oxygen	148-154	ATR serine/threonine kinase	Homo sapiens	27-30
34787379-6	2022	Especially, the sustained oxygen evolution for suppressing the gene expression of hypoxia-inducible factor 1alpha (HIF-1alpha) further boosts and augments the SDT efficiency.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-113
34787379-6	2022	Especially, the sustained oxygen evolution for suppressing the gene expression of hypoxia-inducible factor 1alpha (HIF-1alpha) further boosts and augments the SDT efficiency.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
34862108-7	2022	Functions of cardiac muscle contraction, actin cytoskeleton and oxygen binding were significantly changed in the heart cells, which were involved in the altered expressions of tnni2a.4, acta1a, atp1a1a.2, mylpfa, and so on.	Oxygen	64-70	ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2	Danio rerio	194-203
34883381-5	2022	Theoretical calculations showed the dioxygen transfer could occur by Fe(VI) attacking the CC double-bond in benzene ring of BP-1 to form a five-membered ring intermediate, which was hydrolyzed twice followed by H-abstraction to generate the dihydroxy-added product directly from the parent compound.	Oxygen	36-44	BP1	Homo sapiens	124-128
34883381-8	2022	This work illustrates Fe(VI) could remove BP-1 in water environments efficiently, and the newly proposed dioxygen transfer mechanism herein may contribute to the development of Fe(VI) chemistry.	Oxygen	105-113	BP1	Homo sapiens	42-46
34715100-3	2022	The 3DHP Co-N-C-2 with 129 nm macropore exhibits excellent ORR performance in 0.1 M KOH solution with a half-wave potential of 0.80 V vs. RHE and superior durability than Pt/C (20%) due to the specific macropore-mesopore-micropore structure that exposes a large number of active sites and accelerates the electrolyte transport and oxygen diffusion.	Oxygen	331-337	dihydropyrimidinase	Homo sapiens	5-8
34689109-3	2022	The redox reaction between the Sn2+ ions from the Zn-SnO-II sample and the surface oxygen-containing functional groups from functionalized carbon nanotube (F-CNT) and graphene oxide (GO) leads to the formation of the final Zn-SnO2/CNT@RGO composites.	Oxygen	83-89	solute carrier family 38 member 5	Homo sapiens	31-34
34728328-21	2022	The high-pressure sensitive sod1 mutants were also susceptible to sublethal levels of the O2 - generator paraquat.	Oxygen	90-92	superoxide dismutase 1	Homo sapiens	28-32
34728328-23	2022	CONCLUSIONS: High pressure enhances O2 - production and Sod1 within the IMS plays a role in scavenging O2 - allowing the cells to grow under high pressure.	Oxygen	103-107	superoxide dismutase 1	Homo sapiens	56-60
34953447-11	2022	Of note, MEKK3 over-expression almost abrogated the capacity of TRAF7 knockout to mitigate neuronal death and neuroinflammation in the isolated primary cortical neurons and glial cells upon oxygen-glucose-deprivation/reperfusion (OGD/R) stimulation.	Oxygen	190-196	TNF receptor-associated factor 7	Mus musculus	64-69
34891118-6	2022	In addition, capsaicin increased intracellular oxygen levels by suppressing mitochondrial respiration, resulting in a reduction of HIF-1alpha accumulation.	Oxygen	47-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
34775001-0	2022	The role of mitochondrial reactive oxygen species in insulin resistance.	Oxygen	35-41	insulin	Homo sapiens	53-60
34775001-3	2022	Here we review the evidence linking mitochondrial reactive oxygen species generated within mitochondria with insulin resistance in adipose tissue and skeletal muscle, two major insulin sensitive tissues.	Oxygen	59-65	insulin	Homo sapiens	109-116
34775001-3	2022	Here we review the evidence linking mitochondrial reactive oxygen species generated within mitochondria with insulin resistance in adipose tissue and skeletal muscle, two major insulin sensitive tissues.	Oxygen	59-65	insulin	Homo sapiens	177-184
34468834-1	2022	PURPOSE: To study the effect of anti-VEGF therapy for diabetic macular edema (DME) on retinal oxygen saturation (O2S) and its correlation with functional and anatomical changes of retinal tissue.	Oxygen	113-116	vascular endothelial growth factor A	Homo sapiens	37-41
34848225-8	2022	The XPS and FT-IR analysis results indicated that the sulfur-, nitrogen- and oxygen-containing groups in the keratin-PAA hydrogel were the main binding sites for Pb(II).	Oxygen	77-83	submaxillary gland androgen regulated protein 3B	Homo sapiens	162-168
34953386-5	2022	Meanwhile, the increase of O2 in tumor-site can affect the metabolism of tumor cells and regulatory T (Treg) cells to reduce cancer cells proliferation by down-regulating the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and c-Myc.	Oxygen	27-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	189-220
34954323-7	2022	Mechanistic studies showed that CHOP accelerated alveolar epithelial cell senescence by promoting reactive oxygen species generation, which activated the nuclear factor-kappa B pathway.	Oxygen	107-113	DNA damage inducible transcript 3	Homo sapiens	32-36
34757095-4	2022	In Step 3, a scission of the C-10-C-19 bond occurs releasing C-19 as formic acid (HCOOH) and incorporating an atom of oxygen from O2, The other oxygen atom of formic acid is derived from the hydroxyl group introduced in Step 1.	Oxygen	118-124	homeobox C10	Homo sapiens	29-33
34757095-4	2022	In Step 3, a scission of the C-10-C-19 bond occurs releasing C-19 as formic acid (HCOOH) and incorporating an atom of oxygen from O2, The other oxygen atom of formic acid is derived from the hydroxyl group introduced in Step 1.	Oxygen	130-132	homeobox C10	Homo sapiens	29-33
34757095-4	2022	In Step 3, a scission of the C-10-C-19 bond occurs releasing C-19 as formic acid (HCOOH) and incorporating an atom of oxygen from O2, The other oxygen atom of formic acid is derived from the hydroxyl group introduced in Step 1.	Oxygen	144-150	homeobox C10	Homo sapiens	29-33
34774692-6	2022	In vitro results demonstrated that the upregulation of FTCD induced by HMON@Mn-PEI@FTCD nanoparticles dramatically reduced intracellular THF levels, inhibited of NADPH/NADP+ and GSH/GSSG ratios, and induced reactive oxygen species generation and mitochondrial oxidative stress.	Oxygen	216-222	formimidoyltransferase cyclodeaminase	Homo sapiens	55-59
34774692-6	2022	In vitro results demonstrated that the upregulation of FTCD induced by HMON@Mn-PEI@FTCD nanoparticles dramatically reduced intracellular THF levels, inhibited of NADPH/NADP+ and GSH/GSSG ratios, and induced reactive oxygen species generation and mitochondrial oxidative stress.	Oxygen	216-222	formimidoyltransferase cyclodeaminase	Homo sapiens	83-87
34878158-2	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
34878158-2	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
34718179-3	2022	Herein, to overcome tumor-associated hypoxia, and further achieve tumor-targeted synergistic chemotherapy/PDT/photothermal therapy (PTT), we have constructed a biodegradable oxygen-producing nanoplatform (named Ini@PM-HP), which was composed of the porous metal-organic framework (PCN-224(Mn)), the poly (ADP-ribose) polymerase (PARP) inhibitor (Iniparib), and the polydopamine-modified hyaluronic acid (HA-PDA).	Oxygen	174-180	poly(ADP-ribose) polymerase 1	Homo sapiens	299-327
34718179-3	2022	Herein, to overcome tumor-associated hypoxia, and further achieve tumor-targeted synergistic chemotherapy/PDT/photothermal therapy (PTT), we have constructed a biodegradable oxygen-producing nanoplatform (named Ini@PM-HP), which was composed of the porous metal-organic framework (PCN-224(Mn)), the poly (ADP-ribose) polymerase (PARP) inhibitor (Iniparib), and the polydopamine-modified hyaluronic acid (HA-PDA).	Oxygen	174-180	poly(ADP-ribose) polymerase 1	Homo sapiens	329-333
34953386-5	2022	Meanwhile, the increase of O2 in tumor-site can affect the metabolism of tumor cells and regulatory T (Treg) cells to reduce cancer cells proliferation by down-regulating the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and c-Myc.	Oxygen	27-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	222-232
34726807-9	2022	Additionally, GSTO2 induction suppressed the expression of beta-catenin and the oxygen consumption rate, but it did not affect the extracellular acidification rate.	Oxygen	80-86	glutathione S-transferase omega 2	Mus musculus	14-19
34742454-2	2022	In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor.	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	260-270
34866334-6	2022	In addition, inhibition of NF-kappaB by the small molecule inhibitor Bay-11-7082 led to lower levels of NLRP3 inflammasomes and cleaved caspase-1 proteins in BV2 cells after oxygen-glucose deprivation and reoxygenation.	Oxygen	174-180	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
34437764-4	2022	We have investigated whether the oxygen consumption rate (OCR) of peripheral blood mononuclear cells (PBMCs) obtained from patients with MCAD, VLCAD, and CUD can be used to study cellular metabolism in patients with FAO defects and to determine the severity of FAO impairment.	Oxygen	33-39	acyl-CoA dehydrogenase medium chain	Homo sapiens	137-141
34695425-7	2022	Furthermore, Rab7 decreased the amount of reactive oxygen species and the amount of Triton X-100 insoluble alphaSyn.	Oxygen	51-57	RAB7A, member RAS oncogene family	Rattus norvegicus	13-17
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	cAMP responsive element binding protein 1	Mus musculus	178-215
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	cAMP responsive element binding protein 1	Mus musculus	217-221
34739899-11	2022	The most striking results of serum midkine levels were corelation between length of hospitalization (p: 0.01, r: 0.430) and O2 saturation (p < 0.0001, r: -0.521).	Oxygen	124-126	midkine	Homo sapiens	35-42
34940908-3	2022	To power cellular energetics O2 reaches its muscle mitochondrial target by dissociating from hemoglobin, crossing the red cell membrane, plasma, endothelial surface layer, endothelial cell, interstitial space, myocyte sarcolemma and a variable expanse of cytoplasm before traversing the mitochondrial outer/inner membranes and reacting with reduced cytochrome c and protons.	Oxygen	29-31	cytochrome c, somatic	Homo sapiens	349-361
34801549-7	2022	MCU KO cells also maintained normal ATP levels, but showed increased proliferation, oxygen consumption, and metabolism of both glucose and glutamine.	Oxygen	84-90	mitochondrial calcium uniporter	Homo sapiens	0-3
34801549-10	2022	However, in MCU KO cells, the higher energy expenditure associated with increased proliferation and oxygen consumption makes these cells more prone to bioenergetic failure under conditions of metabolic stress.	Oxygen	100-106	mitochondrial calcium uniporter	Homo sapiens	12-15
34971797-5	2022	However, the addition of active oxygen scavenger N-acetylcysteine can significantly reduce the ROS production, improve cell cycle arrest, reduce apoptosis, and the expression of phosphorylated NF-kappaB in BV2 microglia cells.	Oxygen	32-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	193-202
34369657-0	2022	JMJD5 attenuates oxygen-glucose deprivation and reperfusion-induced injury in cardiomyocytes through regulation of HIF-1alpha-BNIP3.	Oxygen	17-23	lysine demethylase 8	Rattus norvegicus	0-5
34713633-3	2022	Additionally, the oxygen-independent mechanism of regulating HIF-1 acts a vital part in different stages of tumor progression as well as chemo-/radio-/PDT resistance, resulting in poor curative effects and prognosis.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
34967939-9	2021	CONCLUSIONS: Increasing the dose of catecholamines is associated with higher lactate and NSE concentration, which may suggest their importance for tissue oxygen delivery, anaerobic metabolism, and organ function early after OHCA.	Oxygen	154-160	enolase 2	Homo sapiens	89-92
34965614-4	2022	Interestingly, the h+ can trigger the decomposition of H2 O2 to generate O2 for alleviating tumor hypoxia, which not only sensitizes photodynamic therapy (PDT) and radiotherapy (RT), but also promotes the tumor-associated macrophages (TAMs) polarization from M2 to M1 phenotype, beneficial to decrease the expression of HIF-1alpha.	Oxygen	73-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	320-330
34401997-9	2022	In vitro, Zeb2/Axin2-enriched exosomes significantly increased neurite branching and elongation of cultured cortical embryonic rat neurons under oxygen- and glucose-deprived (OGD) conditions.	Oxygen	145-151	zinc finger E-box binding homeobox 2	Rattus norvegicus	10-14
34920444-10	2021	The variation of TCP as a function of (O2)avexhibited the minimum at (O2)avof 2.7%.	Oxygen	39-41	serine peptidase inhibitor Kazal type 1	Homo sapiens	17-20
34920444-10	2021	The variation of TCP as a function of (O2)avexhibited the minimum at (O2)avof 2.7%.	Oxygen	70-72	serine peptidase inhibitor Kazal type 1	Homo sapiens	17-20
34920444-12	2021	On the other hand, the direct radiation damage increased, and the apoptosis decreased for higher (O2)av, resulting in a higher TCP.	Oxygen	98-100	serine peptidase inhibitor Kazal type 1	Homo sapiens	127-130
34920444-13	2021	We showed by modeling the radiation damage of blood vessels in a 2D CA simulation that the indirect apoptotic death of cancer cells, caused by the reduction of the oxygen level due to vascular damage after high dose irradiation, increased TCP.	Oxygen	164-170	serine peptidase inhibitor Kazal type 1	Homo sapiens	239-242
34967955-0	2022	Low oxygen concentration improves yak oocyte maturation and inhibits apoptosis through HIF-1 and VEGF.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
34967955-0	2022	Low oxygen concentration improves yak oocyte maturation and inhibits apoptosis through HIF-1 and VEGF.	Oxygen	4-10	vascular endothelial growth factor A	Homo sapiens	97-101
34967955-4	2022	Then, TUNEL analysis showed that the 5% oxygen concentration group significantly inhibited apoptosis of cumulus-oocyte complexes (COCs) compared to the other group, and the transcription and protein levels of pro-apoptotic factor Bax, HIF-1alpha and VEGF in yak COCs significantly reduced, while anti-apoptotic factor Bcl-2 significantly increased.	Oxygen	40-46	BCL2 associated X, apoptosis regulator	Homo sapiens	230-233
34967955-4	2022	Then, TUNEL analysis showed that the 5% oxygen concentration group significantly inhibited apoptosis of cumulus-oocyte complexes (COCs) compared to the other group, and the transcription and protein levels of pro-apoptotic factor Bax, HIF-1alpha and VEGF in yak COCs significantly reduced, while anti-apoptotic factor Bcl-2 significantly increased.	Oxygen	40-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-245
34967955-4	2022	Then, TUNEL analysis showed that the 5% oxygen concentration group significantly inhibited apoptosis of cumulus-oocyte complexes (COCs) compared to the other group, and the transcription and protein levels of pro-apoptotic factor Bax, HIF-1alpha and VEGF in yak COCs significantly reduced, while anti-apoptotic factor Bcl-2 significantly increased.	Oxygen	40-46	vascular endothelial growth factor A	Homo sapiens	250-254
34967955-4	2022	Then, TUNEL analysis showed that the 5% oxygen concentration group significantly inhibited apoptosis of cumulus-oocyte complexes (COCs) compared to the other group, and the transcription and protein levels of pro-apoptotic factor Bax, HIF-1alpha and VEGF in yak COCs significantly reduced, while anti-apoptotic factor Bcl-2 significantly increased.	Oxygen	40-46	BCL2 apoptosis regulator	Homo sapiens	318-323
34967955-6	2022	In summary, our findings demonstrate that 5% oxygen concentration may promote maturation and inhibit apoptosis of oocytes through HIF-1alpha-mediated VEGF expression.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
34967955-6	2022	In summary, our findings demonstrate that 5% oxygen concentration may promote maturation and inhibit apoptosis of oocytes through HIF-1alpha-mediated VEGF expression.	Oxygen	45-51	vascular endothelial growth factor A	Homo sapiens	150-154
34961326-10	2022	In oxygen-exposed rats, we observed lipid deposits, increased superoxide production (isolated cardiomyocytes), and reduced Nrf2 gene expression.	Oxygen	3-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	123-127
34958560-4	2021	As expected, HSA-Mn3O4 effectively inhibits oxygen and glucose deprivation-mediated cell apoptosis and endoplasmic reticulum stress and demonstrates neuroprotective capacity against ischemic stroke and reperfusion injury of brain tissue.	Oxygen	44-50	albumin	Homo sapiens	13-16
34965440-5	2021	Thus, KSHV regulation of the oxygen-sensing machinery allows virally infected cells to initiate translation via the mTOR-dependent eIF4E1 or the HIF2alpha-dependent, mTOR-independent, eIF4E2.	Oxygen	29-35	mechanistic target of rapamycin kinase	Homo sapiens	116-120
34965440-5	2021	Thus, KSHV regulation of the oxygen-sensing machinery allows virally infected cells to initiate translation via the mTOR-dependent eIF4E1 or the HIF2alpha-dependent, mTOR-independent, eIF4E2.	Oxygen	29-35	mechanistic target of rapamycin kinase	Homo sapiens	166-170
34963467-9	2021	High sensitivity to oxygen results in a series of changes such as upregulation of VEGF and IGF-1 may cause ROP-like retinopathy.	Oxygen	20-26	vascular endothelial growth factor A	Homo sapiens	82-86
34963467-9	2021	High sensitivity to oxygen results in a series of changes such as upregulation of VEGF and IGF-1 may cause ROP-like retinopathy.	Oxygen	20-26	insulin like growth factor 1	Homo sapiens	91-96
34968736-2	2022	The Arabidopsis thaliana EXECUTER1 (EX1) protein, a chloroplast-localized singlet oxygen (1O2) sensor, undergoes tryptophan (Trp) 643 oxidation by 1O2, a chloroplast-derived and light-dependent reactive oxygen species.	Oxygen	203-209	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	25-34
34968736-2	2022	The Arabidopsis thaliana EXECUTER1 (EX1) protein, a chloroplast-localized singlet oxygen (1O2) sensor, undergoes tryptophan (Trp) 643 oxidation by 1O2, a chloroplast-derived and light-dependent reactive oxygen species.	Oxygen	203-209	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	36-39
34958665-9	2022	Lama4-/- MSCs displayed increased anti-oxidant activities and promoted AML stem cell proliferation and chemoresistance to cytarabine, which was accompanied by increased mitochondrial transfer from the MSCs to AML cells and reduced reactive oxygen species in AML cells in vitro.	Oxygen	240-246	laminin, alpha 4	Mus musculus	0-5
34958665-10	2022	Similarly, we detected lower levels of reactive oxygen species in AML cells from Lama4-/- mice post-cytarabine treatment.	Oxygen	48-54	laminin, alpha 4	Mus musculus	81-86
34293101-8	2021	Myocardial SGLT1 expression was positively associated with O2.- production and pro-fibrotic, pro-inflammatory, and wall stretch gene expression.	Oxygen	59-61	solute carrier family 5 member 1	Homo sapiens	11-16
34419911-5	2021	The synergistic effect between ROS and RCS promoted by the enhanced oxygen vacancies and the efficient redox recycling of FeIII/FeII and CoIII/CoII.	Oxygen	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
34987705-8	2021	Indeed, GATA4 is upregulated in CRC-AA cells and augments the NF-kappaB activity that underlies the increased expression of cytokines, inhibition of apoptosis, and reduction of reactive oxygen species.	Oxygen	186-192	nuclear factor kappa B subunit 1	Homo sapiens	62-71
34854851-2	2021	Here, a novel oxygen-enhanced hybrid protein nanosonosensitizer system (MnPcS@HPO) is designed using human serum albumin (HSA) and hemoglobin (Hb) through disulfide reconfiguration, followed by encapsulating Mn-phthalocyanine (MnPcS), aiming to develop O2 self-supplementing nanoparticles (NPs) for enhanced SDT.	Oxygen	14-20	albumin	Homo sapiens	113-120
34717963-3	2021	Furthermore, mitochondrial calcium uniporter (MCU) was proved to be up-regulated in RY10-4-treated MDA-MB-231 cells, which resulted in the overload of mitochondrial calcium ((Ca2+)m) and subsequently disrupted mitochondrial functions (characterized by mitochondrial reactive oxygen species (mtROS) accumulation, membrane potential (DeltaPsim) depolarization and permeability transition pore (mPTP) opening).	Oxygen	275-281	mitochondrial calcium uniporter	Homo sapiens	46-49
34922569-12	2021	In PDIA3-/- CMECs, mitochondrial membrane potential and reactive oxygen species production, but not mitochondrial mass, was increased, suggesting an increased mitochondrial bioenergetic capacity.	Oxygen	65-71	protein disulfide isomerase family A member 3	Homo sapiens	3-8
34922569-13	2021	Finally, PDIA3-/- CMECs were more resistant to oxygen-glucose deprivation, while STAT3 inhibition reduced the protective effect.	Oxygen	47-53	protein disulfide isomerase family A member 3	Homo sapiens	9-14
34919312-3	2022	The mechanism of the process involves the 1,2-fluorine and oxygen migrations of the in-situ formed TMS-protected alpha -aminodifluoromethyl carbinol intermediates, which represents a new type of deoxyfluorination reaction.	Oxygen	59-65	PYD and CARD domain containing	Homo sapiens	99-102
34842266-6	2021	In addition, the presence of copper ions could allow glutathione (GHS) to be consumed and oxygen to be produced, likely suppressing the expression of P-glycoprotein (P-gp) and overcoming the issue of MDR relating to LT. More importantly, synergistic chemo-photothermal therapy with LT and Cu2-xS NCs was more effective than any single therapy or theoretical combination.	Oxygen	90-96	ATP binding cassette subfamily B member 1	Homo sapiens	150-164
34842266-6	2021	In addition, the presence of copper ions could allow glutathione (GHS) to be consumed and oxygen to be produced, likely suppressing the expression of P-glycoprotein (P-gp) and overcoming the issue of MDR relating to LT. More importantly, synergistic chemo-photothermal therapy with LT and Cu2-xS NCs was more effective than any single therapy or theoretical combination.	Oxygen	90-96	ATP binding cassette subfamily B member 1	Homo sapiens	166-170
34948281-7	2021	Decreases in the oxygen consumption rate (OCR) and the OCR:ECAR (extracellular acidification rate) ratio in the patient"s fibroblasts indicated reduced electron flow through the respiratory chain, and spectrophotometry revealed decreased activity of OXPHOS complexes I and V. We demonstrate a clear defect in mitochondrial function in the patient"s fibroblasts and describe the possible molecular mechanism underlying the pathogenicity of this novel AGK variant.	Oxygen	17-23	acylglycerol kinase	Homo sapiens	450-453
34907153-6	2021	Bindings of AOPPs to RANK and RAGE were able to activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, trigger generation of reactive oxygen species, then induce phosphorylation of mitogen-activated protein kinases and c-fos, upregulation of the nuclear factor of activated T cell c1, eventually induce bone marrow monocytes to differentiate into mature osteoclasts.	Oxygen	149-155	advanced glycosylation end product-specific receptor	Mus musculus	30-34
34907357-14	2021	Lower splanchnic oxygen saturation and reduction of its variability are associated with higher urinary I-FABP levels in anemic preterm infants before their first RBC transfusion.	Oxygen	17-23	fatty acid binding protein 2	Homo sapiens	103-109
34966392-4	2021	Hypoxia inducible factor-1alpha (HIF-1alpha) is a sensitive regulator of oxygen homeostasis, and its expression is rapidly induced after hypoxia/ischemia.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
34966392-4	2021	Hypoxia inducible factor-1alpha (HIF-1alpha) is a sensitive regulator of oxygen homeostasis, and its expression is rapidly induced after hypoxia/ischemia.	Oxygen	73-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
34890296-3	2022	Test the hypothesis that UCP2 has a major function of reducing O2 - generation in the lung in ambient air or in hyperoxia.	Oxygen	63-65	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	25-29
34871150-4	2021	Moreover, the effects of HPC on oxygen-glucose deprivation/reperfusion (OGD/R)-induced apoptosis and autophagy in SH-SY5Y cells were explored to further reveal the possible mechanisms underlying HPC.Results: BNIP3-siRNA attenuated the protective effects of HPC by decreasing the cell viability, increasing the enzymatic activity of caspase-3 and 9, increasing the rate of apoptosis, and increasing the protein expression level of activated caspase-3.	Oxygen	32-38	BCL2 interacting protein 3	Homo sapiens	208-213
34871150-4	2021	Moreover, the effects of HPC on oxygen-glucose deprivation/reperfusion (OGD/R)-induced apoptosis and autophagy in SH-SY5Y cells were explored to further reveal the possible mechanisms underlying HPC.Results: BNIP3-siRNA attenuated the protective effects of HPC by decreasing the cell viability, increasing the enzymatic activity of caspase-3 and 9, increasing the rate of apoptosis, and increasing the protein expression level of activated caspase-3.	Oxygen	32-38	caspase 3	Homo sapiens	440-449
34946583-1	2021	sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a monosaccharide-like glycone moiety with a pseudoamide-type nitrogen replacing the endocyclic oxygen atom of carbohydrates and an axially-oriented lipid chain anchored at the pseudoanomeric position.	Oxygen	205-211	Sp2 transcription factor	Homo sapiens	0-3
34946583-1	2021	sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a monosaccharide-like glycone moiety with a pseudoamide-type nitrogen replacing the endocyclic oxygen atom of carbohydrates and an axially-oriented lipid chain anchored at the pseudoanomeric position.	Oxygen	205-211	Sp2 transcription factor	Homo sapiens	28-31
34890296-7	2022	UCP2 mRNA and protein expression were acutely decreased in hyperoxia, which were associated with significant increase in O2 - production in the lung.	Oxygen	121-125	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	0-4
34890296-12	2022	Loss of UCP2 in hyperoxia is a major mechanism of O2 - production in the lung in hyperoxia.	Oxygen	50-54	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	8-12
34956992-0	2021	Vascular Endothelial Growth Factor Signaling in Models of Oxygen-Induced Retinopathy: Insights Into Mechanisms of Pathology in Retinopathy of Prematurity.	Oxygen	58-64	vascular endothelial growth factor A	Homo sapiens	0-34
34956890-0	2021	Overexpression of Reactive Oxygen Species Modulator 1 Predicts Unfavorable Clinical Outcome in EGFR-Mutant Lung Adenocarcinomas Treated With Targeted Therapy.	Oxygen	27-33	epidermal growth factor receptor	Homo sapiens	95-99
34956992-5	2021	In this manuscript, we review the role of receptors that interact with VEGF in oxygen-induced retinopathy (OIR) models that represent features of ROP pathology.	Oxygen	79-85	vascular endothelial growth factor A	Homo sapiens	71-75
34955879-0	2021	Enhanced Oxygen Utilization Efficiency With Concomitant Activation of AMPK-TBC1D1 Signaling Nexus in Cyclophilin-D Conditional Knockout Mice.	Oxygen	9-15	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	101-114
34955879-1	2021	We have previously reported in HEK 293 T cells and in constitutive cyclophilin-D (Cyp-D) knockout (KO) mice that Cyp-D ablation downregulates oxygen consumption (VO2) and triggers an adaptive response that manifest in higher exercise endurance with less VO2.	Oxygen	142-148	peptidylprolyl isomerase F	Homo sapiens	67-80
34955879-1	2021	We have previously reported in HEK 293 T cells and in constitutive cyclophilin-D (Cyp-D) knockout (KO) mice that Cyp-D ablation downregulates oxygen consumption (VO2) and triggers an adaptive response that manifest in higher exercise endurance with less VO2.	Oxygen	142-148	peptidylprolyl isomerase F	Homo sapiens	82-87
34718251-0	2021	Increased endogenous reactive oxygen species normalizes proliferation defects of Bmi1 heterozygous knockout neural stem cells.	Oxygen	30-36	Bmi1 polycomb ring finger oncogene	Mus musculus	81-85
34955879-1	2021	We have previously reported in HEK 293 T cells and in constitutive cyclophilin-D (Cyp-D) knockout (KO) mice that Cyp-D ablation downregulates oxygen consumption (VO2) and triggers an adaptive response that manifest in higher exercise endurance with less VO2.	Oxygen	142-148	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	113-118
34955879-9	2021	Taken together, our study demonstrates that like constitutive Cyp-D ablation, acute Cyp-D ablation also induces a state of increased O2 utilization efficiency, paving the way for exploring the use of pharmacological approach to elicit the same response, which could be beneficial under O2 limiting conditions.	Oxygen	133-135	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	84-89
34955879-9	2021	Taken together, our study demonstrates that like constitutive Cyp-D ablation, acute Cyp-D ablation also induces a state of increased O2 utilization efficiency, paving the way for exploring the use of pharmacological approach to elicit the same response, which could be beneficial under O2 limiting conditions.	Oxygen	286-288	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	84-89
33345622-3	2021	HIF1alpha is a master transcription factor involved in the cellular response to oxygen levels.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
34816851-0	2021	Ce-Doped Ni-S nanosheets on Ni foam supported NiMoO4 micropillars: fast electrodeposition, improved electrocatalytic activity and ultralong durability for the oxygen evolution reaction in various electrolytes.	Oxygen	159-165	solute carrier family 5 member 5	Homo sapiens	9-13
34661337-8	2021	Tet2/3 cooperatively induces Prdm1 expression via oxygen-dependent DNA demethylation, which in turn activates NFATc1 required for osteoclastogenesis.	Oxygen	50-56	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	110-116
34569106-4	2021	The dative interaction between the B atom and the sp2 N atom of g-C3 N4 guarantees the high dispersion of boron-oxo species, where O atoms coordinate with single Ni (II) sites to obtain a unique six-oxygen-coordinated configuration.	Oxygen	199-205	Sp2 transcription factor	Homo sapiens	50-53
34580926-5	2021	Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O2 to tumor directly, 2) generating O2 in situ, 3) reducing tumor cellular O2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia-inducible factor 1 (HIF-1) signaling pathway to relieve tumor hypoxia.	Oxygen	141-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	383-409
34580926-5	2021	Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O2 to tumor directly, 2) generating O2 in situ, 3) reducing tumor cellular O2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia-inducible factor 1 (HIF-1) signaling pathway to relieve tumor hypoxia.	Oxygen	141-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	411-416
34880123-6	2022	Furthermore, we reveal that cAMP-mediated PARP1-activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events.	Oxygen	96-102	poly(ADP-ribose) polymerase 1	Homo sapiens	42-47
34876210-2	2021	Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellular redox homeostasis by decomposing hydrogen peroxide to either water or oxygen that oxidize and provide fuel for cellular metabolism.	Oxygen	155-161	catalase	Mus musculus	0-8
34881324-5	2021	Superoxide anion (O2 -) production was determined from the rate of reduction of cytochrome c.	Oxygen	18-22	cytochrome c, somatic	Homo sapiens	80-92
34988401-5	2022	Of note, LIPUS transferred sonomechanical energy into cytochrome c and B5 proteins, which converted oxygen molecules into singlet oxygen, triggering telomere crisis.	Oxygen	100-106	cytochrome c, somatic	Homo sapiens	54-66
34716681-3	2021	Benefiting from the catalytic property of loaded LOX and O2 self-supplying of PFOB nanodroplets, PTFL nanoparticles (NPs) efficiently deplete tumoral lactate for down-regulation of vascular endothelial growth factor expression and supplement the insufficient endogenous H2 O2 .	Oxygen	57-59	vascular endothelial growth factor A	Homo sapiens	181-215
34601098-1	2021	SIRT2, a Class III HDACs, aggravates cell damage and activates caspase-3 under oxygen-glucose deprivation/reoxygenation and glucose (OGD/R) conditions.	Oxygen	79-85	caspase 3	Homo sapiens	63-72
34550057-13	2021	These results indicate that the oxygen-dependent variation of the migration speed of vascular endothelial cells is mediated by the regulation of VE-cadherin through the PAK pathway, as well as other mechanisms via HIF-1alpha, especially under extreme hypoxic conditions.	Oxygen	32-38	cadherin 5	Homo sapiens	145-156
34550057-13	2021	These results indicate that the oxygen-dependent variation of the migration speed of vascular endothelial cells is mediated by the regulation of VE-cadherin through the PAK pathway, as well as other mechanisms via HIF-1alpha, especially under extreme hypoxic conditions.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-224
34857197-7	2021	Patients who received PN had a significantly lower odds (p < 0.001) of oxygen escalation in comparison to their control group counterparts (OR = 0.804, 95% CI 0.720, 0.899) when matched for age, body mass index, Charlson comorbidity index, and gender.	Oxygen	71-77	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	22-24
34857197-8	2021	CONCLUSION: Initiating PN in the setting of non-invasive ventilation of SARS-CoV-2 infected patients was significantly associated with a lower odds of oxygen escalation.	Oxygen	151-157	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	23-25
34721681-7	2021	Culture of HA-VSMCs under hypoxic conditions (1% O2) reduced the expression of RP11-531A24.3, and enhanced the protein expression of ANXA2 and HIF-1alpha, while knockdown of ANXA2 downregulated the protein expression of HIF-1alpha.	Oxygen	49-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-153
34520834-6	2021	APF can specifically recognize EGFR-positive NSCLC cells and effectively improve the tumor hypoxic microenvironment due to the targeting effect of aptamer and the good oxygen-carrying capacity of the fluorinated dendrimer.	Oxygen	168-174	epidermal growth factor receptor	Homo sapiens	31-35
34724256-1	2021	The hypoxia-inducible nuclear-encoded mitochondrial protein NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) has been demonstrated to decrease oxidative phosphorylation and production of reactive oxygen species in neonatal cardiomyocytes, brain tissue and hypoxic domains of cancer cells.	Oxygen	219-225	Ndufa4, mitochondrial complex associated like 2	Mus musculus	60-120
34724256-1	2021	The hypoxia-inducible nuclear-encoded mitochondrial protein NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) has been demonstrated to decrease oxidative phosphorylation and production of reactive oxygen species in neonatal cardiomyocytes, brain tissue and hypoxic domains of cancer cells.	Oxygen	219-225	Ndufa4, mitochondrial complex associated like 2	Mus musculus	122-130
34724256-6	2021	Ectopic NDUFA4L2 expression resulted in reduced mitochondrial respiration and reactive oxygen species followed by lowered AMP, ADP, ATP, and NAD+ levels without affecting the overall protein content of the mitochondrial electron transport chain.	Oxygen	87-93	Ndufa4, mitochondrial complex associated like 2	Mus musculus	8-16
34420157-3	2021	In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of alpha5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells.	Oxygen	126-132	thymoma viral proto-oncogene 1	Mus musculus	355-358
34559475-6	2021	RESULTS: Female adult (~12-month-old) Sod1KO mice show a number of sarcopenia-related phenotypes in skeletal muscle including reduced mitochondrial oxygen consumption and elevated reactive oxygen species generation, fragmentation, and loss of innervated NMJs (P < 0.05), a 30% reduction in muscle mass (P < 0.05), a 36% loss of force generation (P < 0.05), and a loss of exercise capacity (305 vs. 709 m in wild-type mice, P < 0.05).	Oxygen	148-154	superoxide dismutase 1, soluble	Mus musculus	38-42
34559475-6	2021	RESULTS: Female adult (~12-month-old) Sod1KO mice show a number of sarcopenia-related phenotypes in skeletal muscle including reduced mitochondrial oxygen consumption and elevated reactive oxygen species generation, fragmentation, and loss of innervated NMJs (P < 0.05), a 30% reduction in muscle mass (P < 0.05), a 36% loss of force generation (P < 0.05), and a loss of exercise capacity (305 vs. 709 m in wild-type mice, P < 0.05).	Oxygen	189-195	superoxide dismutase 1, soluble	Mus musculus	38-42
34545968-2	2021	Our previous study showed that AGE-induced reactive oxygen species-dependent apoptosis is mediated via protein kinase C delta (PKCdelta)-enhanced mitochondrial damage in cardiomyocytes.	Oxygen	52-58	renin binding protein	Homo sapiens	31-34
34581931-0	2021	MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro.	Oxygen	20-26	microRNA 361	Rattus norvegicus	0-7
34934614-3	2021	Hypoxia (low oxygen tensions), which may develop in tumors as a pathological response to the metabolic demands of the proliferating cells and as a physiological state in the bone, downregulates LIFR in breast cancer cells independent of hypoxia-inducible factor (HIF) signaling.	Oxygen	13-19	LIF receptor subunit alpha	Homo sapiens	194-198
34678616-6	2021	Here we show that this antagonistic effect can be attributed to human serum albumin, which represents the largest pool of free thiols in plasma for trapping reactive oxygen species.	Oxygen	166-172	albumin	Homo sapiens	70-83
34661812-0	2021	Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner.	Oxygen	56-62	fibroblast growth factor 9	Mus musculus	38-42
34734476-7	2021	In addition, STIP1 was found to ameliorate oxygen and glucose deprivation (OGD)-induced inflammation and activation of NF-kappaB signalling in mouse microglia BV2 cells, and STIP1 resulted in decrease of heat shock protein family A member 8 (HSPA8), increase of IkappaBbeta expression and reduced binding of IkappaBbeta to HSPA8 in BV2 cells.	Oxygen	43-49	stress-induced phosphoprotein 1	Mus musculus	13-18
34734476-7	2021	In addition, STIP1 was found to ameliorate oxygen and glucose deprivation (OGD)-induced inflammation and activation of NF-kappaB signalling in mouse microglia BV2 cells, and STIP1 resulted in decrease of heat shock protein family A member 8 (HSPA8), increase of IkappaBbeta expression and reduced binding of IkappaBbeta to HSPA8 in BV2 cells.	Oxygen	43-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
34436746-0	2021	Silencing of H19 alleviates oxygen-glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.	Oxygen	28-34	microRNA 1306	Homo sapiens	116-124
34388291-1	2021	The hypoxia-inducible factor HIF-1 is essential for oxygen homeostasis.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
34581931-0	2021	MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro.	Oxygen	20-26	sequestosome 1	Rattus norvegicus	111-117
34388291-8	2021	We suggest that ERK-mediated phosphorylation of HIF-1alpha regulates its physical interaction with NPM1, which is essential for productive association of HIF-1 with hypoxia target genes and their optimal transcriptional activation, required for survival under low oxygen or tumor growth.	Oxygen	264-270	mitogen-activated protein kinase 1	Homo sapiens	16-19
34388291-8	2021	We suggest that ERK-mediated phosphorylation of HIF-1alpha regulates its physical interaction with NPM1, which is essential for productive association of HIF-1 with hypoxia target genes and their optimal transcriptional activation, required for survival under low oxygen or tumor growth.	Oxygen	264-270	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
34388291-8	2021	We suggest that ERK-mediated phosphorylation of HIF-1alpha regulates its physical interaction with NPM1, which is essential for productive association of HIF-1 with hypoxia target genes and their optimal transcriptional activation, required for survival under low oxygen or tumor growth.	Oxygen	264-270	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-159
34181038-3	2021	The purpose of this study is to characterize the effects of vasopressin infusions on hemodynamics and systemic oxygen delivery in children with congenital heart disease.	Oxygen	111-117	arginine vasopressin	Homo sapiens	60-71
34627957-9	2021	The HIF-3alpha expression profile was related to cellular phenotype as it was lower in BEAS-2B and higher in A549 cells under low oxygen tension.	Oxygen	130-136	hypoxia inducible factor 3 subunit alpha	Homo sapiens	4-14
34263424-0	2021	Effects of Temperature and Position Change on Neonatal Brain Regional Oxygen Saturation in Tub Bathing: A Prospective Study.	Oxygen	70-76	TUB bipartite transcription factor	Homo sapiens	91-94
34116494-6	2021	Furthermore, the oxygen-containing groups of wheat proteins, the nitrogen-containing groups of albumins and globulins, and the sulfur-containing groups of gliadins and glutenins were found to offer coordination sites for Pb(II).	Oxygen	17-23	submaxillary gland androgen regulated protein 3B	Homo sapiens	221-227
34943016-5	2021	We also performed tubule formation assays on control- or AMPKalpha1-siRNA transfected HPMECs, exposed to 21% O2 or 70% O2 for 48 h. Hyperoxia-mediated alveolar and pulmonary vascular simplification, pulmonary vascular remodeling, and PH were significantly amplified in endothelial AMPKalpha1-deficient mice.	Oxygen	109-111	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	281-291
34943016-5	2021	We also performed tubule formation assays on control- or AMPKalpha1-siRNA transfected HPMECs, exposed to 21% O2 or 70% O2 for 48 h. Hyperoxia-mediated alveolar and pulmonary vascular simplification, pulmonary vascular remodeling, and PH were significantly amplified in endothelial AMPKalpha1-deficient mice.	Oxygen	119-121	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	281-291
34884703-3	2021	Accumulating evidence suggests that the short cycles of decreased oxygen saturation and rapid reoxygenation, a typical feature of SAS, contribute to the development of glucose intolerance and insulin resistance.	Oxygen	66-72	insulin	Homo sapiens	192-199
34850552-2	2022	However, it delivers a low reversible practical capacity (<200 mA h g-1 ) due to the irreversible oxygen redox at high potentials (>4.5 V).	Oxygen	98-104	polycystin 1, transient receptor potential channel interacting pseudogene 1	Homo sapiens	66-71
34850552-4	2022	F substitution with O stabilizes the layered anionic framework, completely inhibits the O2 evolution during the first cycle, and greatly enhances the reversibility of oxygen redox, delivering an ultrahigh reversible capacity of 389 mA h g-1 , which is 85% of the theoretical capacity of Li2 MnO3 .	Oxygen	167-173	polycystin 1, transient receptor potential channel interacting pseudogene 1	Homo sapiens	235-240
34126569-1	2021	Myoglobin (Mb), hemeprotein that binds dioxygen in muscle, affects meat colour.	Oxygen	39-47	myoglobin	Gallus gallus	0-9
34838849-9	2021	Tbeta4 ameliorated oxidative damage and suppressed reactive oxygen species production in Abeta-treated SH-SY5Y cells.	Oxygen	60-66	amyloid beta precursor protein	Homo sapiens	89-94
34943006-5	2021	Insulin resistance followed by hyperglycemia often results in oxidative stress level enhancement and increased reactive oxygen species production.	Oxygen	120-126	insulin	Homo sapiens	0-7
34868528-15	2021	In conclusion, SNHG15 expression increased during the process of oxygen-glucose-deprived reoxygenation, and the oxidative stress process was reduced by miR-141/SIRT1.	Oxygen	65-71	microRNA 141	Homo sapiens	152-159
34885789-1	2021	Leghemoglobin (Lb) is an oxygen-binding plant hemoglobin of legume nodules, which participates in the symbiotic nitrogen fixation process.	Oxygen	25-31	leghemoglobin A	Glycine max	0-13
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	microRNA 141	Homo sapiens	87-94
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	tumor necrosis factor	Homo sapiens	173-182
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	interleukin 6	Homo sapiens	199-203
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	microRNA 141	Homo sapiens	88-95
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	tumor necrosis factor	Homo sapiens	174-183
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	interleukin 6	Homo sapiens	189-193
34825700-6	2021	Both TWIST1-silencing-induced and irradiation-induced senescent MSCs had a higher oxygen consumption rate compared to control MSCs, while TWIST1-silencing-induced senescent MSCs had a low extracellular acidification rate compared to irradiation-induced senescent MSCs.	Oxygen	82-88	twist family bHLH transcription factor 1	Homo sapiens	5-11
34824221-2	2021	Integrated into membranes they use four electrons from cytochrome c molecules to reduce molecular oxygen (dioxygen) to water.	Oxygen	98-104	cytochrome c, somatic	Homo sapiens	55-67
34824221-2	2021	Integrated into membranes they use four electrons from cytochrome c molecules to reduce molecular oxygen (dioxygen) to water.	Oxygen	106-114	cytochrome c, somatic	Homo sapiens	55-67
34869377-2	2021	Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth factors, and oxygen levels.	Oxygen	228-234	mechanistic target of rapamycin kinase	Homo sapiens	0-29
34818544-0	2021	Suppression of breast cancer progression by FBXL16 via oxygen-independent regulation of HIF1alpha stability.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-97
34830491-3	2021	HIF-1alpha is a transcription factor regulated by the presence or absence of O2.	Oxygen	77-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
34830491-6	2021	Moreover, in GB, HIF-1 is not solely modulated by oxygen but also by oncogenic signaling pathways, such as MAPK/ERK, p53, and PI3K/PTEN.	Oxygen	50-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
34899724-10	2021	Potential risk factors for progression were investigated in the supportive care group and SpO2 < 97% and CRP elevation >1.5 mg/dL were common risk factors for O2 support and progression to severe disease.	Oxygen	159-161	C-reactive protein	Homo sapiens	105-108
34869377-2	2021	Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth factors, and oxygen levels.	Oxygen	228-234	mechanistic target of rapamycin kinase	Homo sapiens	31-35
34869425-11	2021	Gut transcriptome analysis identified 1,747 DEGs and 171 signaling pathways and immunoblotting verified TLR-4, NOD-like receptor, and apoptosis signaling pathways were activated in oxygen-induced gut injury.	Oxygen	181-187	toll-like receptor 4	Mus musculus	104-109
34792741-7	2021	However, individuals who experienced lower oxygen saturation were more likely to exhibit higher total leukocyte and neutrophil counts, a higher neutrophil-lymphocyte ratio (NLR), and an increased concentration of C-reactive protein.	Oxygen	43-49	C-reactive protein	Homo sapiens	213-231
34793488-1	2021	Human protoporphyrinogen oxidase IX (hPPO) is an oxygen-dependent enzyme catalyzing the penultimate step in the heme biosynthesis pathway.	Oxygen	49-55	protoporphyrinogen oxidase	Homo sapiens	37-41
34627804-1	2021	The purpose of this study is to investigate the protective effect of dehydrocostuslactone (DHL) on PC12 cells injury induced by oxygen and glucose deprivation/reperfusion (OGD/R) and its possible mechanism on the PI3K/AKT/mTOR pathway.	Oxygen	128-134	AKT serine/threonine kinase 1	Rattus norvegicus	218-221
34799218-6	2022	Compared with the Traj-1 group, the Traj-3 group had a significantly lower initial Sequential Organ Failure Assessment score, similar vasopressor use rate, and a higher fraction of inspired oxygen.	Oxygen	190-196	T cell receptor alpha joining 3	Homo sapiens	36-42
34782065-7	2022	In multivariate analyses: age, body mass index, female sex, neck circumference, AHI, and desaturation markers (nadir and mean oxygen saturation) were independently associated with higher CRP.	Oxygen	126-132	C-reactive protein	Homo sapiens	187-190
34254829-5	2021	In addition, some of the main hallmarks of cancer cells, such as redox homeostasis and oxygen-sensing regulation (through inhibition of HIF-1alpha activity), are affected by vitamin C.	Oxygen	87-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
34606937-6	2021	Furthermore, the hydrogen peroxide generated by GOx as well as overexpressed in tumor can be decomposed by CAT and continuously generate oxygen, which further enhance the efficacy of oxygen-dependent starvation therapy and photodynamic therapy.	Oxygen	137-143	catalase	Homo sapiens	107-110
34606937-6	2021	Furthermore, the hydrogen peroxide generated by GOx as well as overexpressed in tumor can be decomposed by CAT and continuously generate oxygen, which further enhance the efficacy of oxygen-dependent starvation therapy and photodynamic therapy.	Oxygen	183-189	catalase	Homo sapiens	107-110
34623134-3	2021	Moreover, the continuous oxygen consumption during PDT also leads to the upregulated expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which can aggravate the growth of tumors.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-130
34623134-3	2021	Moreover, the continuous oxygen consumption during PDT also leads to the upregulated expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which can aggravate the growth of tumors.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-142
34708983-6	2021	The adsorption mechanism of Pb(II) by KBC oxygen-containing and manganese-containing groups was through complexation and precipitation, and the formation of -O-Pb-O- bidentate complexes on the surface of the biochar.	Oxygen	42-48	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
34743630-0	2022	Lower cerebral oxygen utilization is associated with Alzheimer"s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E epsilon4 carriers.	Oxygen	15-21	apolipoprotein E	Homo sapiens	138-163
34743630-5	2022	In stratified analyses, lower oxygen metabolism related to worse language (p = 0.02) and episodic memory performance (p = 0.03) among APOE-epsilon4 carriers only.	Oxygen	30-36	apolipoprotein E	Homo sapiens	134-138
34781297-2	2021	In addition, the oxygen-dependent conversion of HIF-1alpha in nucleus pulposus cells is controlled by the protein Proline 4-hydroxylase domain (PHD) family.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
34520770-2	2021	E-cadherin is found as a survival factor in multiple models of breast cancer by suppressing reactive oxygen-mediated apoptosis.	Oxygen	101-107	cadherin 1	Homo sapiens	0-10
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-229
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
34473153-2	2021	Many of these complexes perform catalase reactions via high-valent Mn-oxo or -hydroxo intermediates that oxidize H2O2 to O2, but these intermediates can also oxidize other molecules (e.g., thiols), which is peroxidase reactivity.	Oxygen	121-123	catalase	Homo sapiens	32-40
34747365-3	2021	SPINK1 expression was induced upon hypoxia (O2 < 0.1%) at the transcription initiation level in a HIF-dependent manner, causing an increase in secreted SPINK1 levels.	Oxygen	44-46	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-6
34747365-3	2021	SPINK1 expression was induced upon hypoxia (O2 < 0.1%) at the transcription initiation level in a HIF-dependent manner, causing an increase in secreted SPINK1 levels.	Oxygen	44-46	serine peptidase inhibitor Kazal type 1	Homo sapiens	152-158
34747365-4	2021	SPINK1 proteins were detected both within and around hypoxic regions of xenografted and clinical tumor tissues, and their plasma levels increased in response to decreased oxygen supply to xenografts.	Oxygen	171-177	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-6
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	dynamin 1-like	Mus musculus	34-59
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	dynamin 1-like	Mus musculus	61-65
34741567-5	2022	The latter finding was confirmed in an independent reactive oxygen species release assay using EBA-specific immune complexes combined with recombinant Hsp70.	Oxygen	60-66	heat shock protein 1B	Mus musculus	151-156
34743630-7	2022	Congruence across language and episodic memory results as well as hippocampal and inferior lateral ventricle volume findings suggest that APOE-epsilon4 may interact with cerebral oxygen metabolism in the pathogenesis of Alzheimer"s disease and related neurodegeneration.	Oxygen	179-185	apolipoprotein E	Homo sapiens	138-142
34537235-6	2021	These results demonstrate for the first time that the graduated HIF-1alpha stability profile observed over a range of oxygen tension is not attributed to the binding of or ubiquitination via VHL per se, but is likely due to the preceding events such as the efficacy of oxygen-dependent prolyl hydroxylase-mediated hydroxylation of HIF-1alpha.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
34537235-0	2021	HIF-1alpha hydroxyprolines modulate oxygen-dependent protein stability via single VHL interface with comparable effect on ubiquitination rate.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
34537235-6	2021	These results demonstrate for the first time that the graduated HIF-1alpha stability profile observed over a range of oxygen tension is not attributed to the binding of or ubiquitination via VHL per se, but is likely due to the preceding events such as the efficacy of oxygen-dependent prolyl hydroxylase-mediated hydroxylation of HIF-1alpha.	Oxygen	118-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	331-341
34537235-2	2021	The principal step in this critical cellular process is the hydroxylation of either or both of the two conserved proline residues P402 and P564 within the oxygen-dependent degradation domain (ODD) of HIF-1alpha subunit via prolyl hydroxylases, which is necessary for binding VHL.	Oxygen	155-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	200-210
34537235-6	2021	These results demonstrate for the first time that the graduated HIF-1alpha stability profile observed over a range of oxygen tension is not attributed to the binding of or ubiquitination via VHL per se, but is likely due to the preceding events such as the efficacy of oxygen-dependent prolyl hydroxylase-mediated hydroxylation of HIF-1alpha.	Oxygen	269-275	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
34739656-0	2022	CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p.	Oxygen	35-41	neuronal growth regulator 1	Homo sapiens	99-104
34537235-6	2021	These results demonstrate for the first time that the graduated HIF-1alpha stability profile observed over a range of oxygen tension is not attributed to the binding of or ubiquitination via VHL per se, but is likely due to the preceding events such as the efficacy of oxygen-dependent prolyl hydroxylase-mediated hydroxylation of HIF-1alpha.	Oxygen	269-275	hypoxia inducible factor 1 subunit alpha	Homo sapiens	331-341
34089998-6	2021	Radical capture experiments and ESR tests affirmed that WS-1 photocatalyst produced  OH and  O2-active species, which further confirmed the photogenerated carriers were transmitted through the Z-scheme mode in principle.	Oxygen	93-95	paired box 3	Homo sapiens	56-60
34637270-5	2021	In an in vitro model (oxygen and glucose deprivation and reperfusion, OGD/R) and in vivo model (middle cerebral artery occlusion and reperfusion, MCAO/R) of I/R, the neuronal cells of rats showed significantly up-regulated gene expression of C5aR1, and a notable inflammatory response was demonstrated with elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	Oxygen	22-28	complement C5a receptor 1	Rattus norvegicus	242-247
34637270-5	2021	In an in vitro model (oxygen and glucose deprivation and reperfusion, OGD/R) and in vivo model (middle cerebral artery occlusion and reperfusion, MCAO/R) of I/R, the neuronal cells of rats showed significantly up-regulated gene expression of C5aR1, and a notable inflammatory response was demonstrated with elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	Oxygen	22-28	tumor necrosis factor	Rattus norvegicus	316-343
34900531-2	2021	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a major regulator involved in cellular response to changes of oxygen levels, supporting the adaptation of tumor cells to hypoxia.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
34900531-2	2021	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a major regulator involved in cellular response to changes of oxygen levels, supporting the adaptation of tumor cells to hypoxia.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
34697618-5	2021	Under the action of target TPP, the system can accurately target the mitochondria of breast cancer 4T1 cells, catalyze intracellular glucose to generate H2O2 through GOX, and H2O2 is further used as a catalytic substrate for CAT to generate O2.	Oxygen	241-243	catalase	Mus musculus	225-228
34769371-5	2021	We also focus on the impact of Nrf2 in cardiac ischemia-reperfusion injury, a condition that stimulates the overproduction of reactive oxygen species.	Oxygen	135-141	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
34900540-6	2021	Concurrently, DOX-efflux-associated P-glycoprotein was also inhibited by O2, prolonging drug retention in cancer cells.	Oxygen	73-75	ATP binding cassette subfamily B member 1	Homo sapiens	36-50
34841716-10	2021	Furthermore, baicalein interfered with HIF-1alpha inhibition of mitochondrial biosynthesis, which increased mitochondrial DNA content and mitochondrial numbers, restored the generation of reactive oxygen species in mitochondria, and thus enhanced the TAM-induced mitochondrial apoptotic pathway.	Oxygen	197-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
34494136-12	2021	In VIC cultures treated with glucose in combination with reactive oxygen species (ROS) inhibitor (N-acetyl-L-cysteine), the expression of NF-kappaB and BMP-2 was significantly suppressed.	Oxygen	66-72	nuclear factor kappa B subunit 1	Homo sapiens	138-147
34455040-10	2021	PCBP1 deletion affected mitochondrial morphology and reduced levels of respiratory complexes II and IV, oxygen consumption, and ATP production.	Oxygen	104-110	poly(rC) binding protein 1	Mus musculus	0-5
34535977-6	2021	In particular, binding was predicted between R264 of the FFAR4 and the oxygen of the carboxylate group in ALA, and between E249 of the FFAR4 and the oxygen of the hydroxy group at the C4-position in PHS.	Oxygen	71-77	free fatty acid receptor 4	Meleagris gallopavo	57-62
34535977-6	2021	In particular, binding was predicted between R264 of the FFAR4 and the oxygen of the carboxylate group in ALA, and between E249 of the FFAR4 and the oxygen of the hydroxy group at the C4-position in PHS.	Oxygen	149-155	free fatty acid receptor 4	Meleagris gallopavo	135-140
34257425-3	2021	Thus, low blood oxygen-induced endothelial dysfunction through acceleration of Ang-2 and ET-1 synthesis may alleviate HARs.	Oxygen	16-22	endothelin 1	Rattus norvegicus	89-93
34257425-5	2021	We found that BP increased by 10 mmHg after treatment with 10% O2 (~5500 m above sea level) for 24 h. Consistently, serum Ang-2 and ET-1 levels were increased along with decreases in NO levels.	Oxygen	63-65	endothelin 1	Rattus norvegicus	132-136
34558638-1	2021	Cold-inducible RNA-binding protein (CIRBP) is a cold-shock protein comprised of an RNA-binding motif that is induced by several stressors, such as cold shock, UV radiation, nutrient deprivation, reactive oxygen species and hypoxia.	Oxygen	204-210	cold inducible RNA binding protein	Homo sapiens	0-34
34558638-1	2021	Cold-inducible RNA-binding protein (CIRBP) is a cold-shock protein comprised of an RNA-binding motif that is induced by several stressors, such as cold shock, UV radiation, nutrient deprivation, reactive oxygen species and hypoxia.	Oxygen	204-210	cold inducible RNA binding protein	Homo sapiens	36-41
34107511-8	2021	VO2peak decreased from 35+-6 to 31+-6 ml min-1 kg-1, P<0.001) in women and from 35+-9 to 32+-9 ml min-1 kg-1 (P=0.024) in men in approximate proportion to the reduction of O2 carrying capacity, an effect that did not differ between sexes (P=0.778).	Oxygen	172-174	CD59 molecule (CD59 blood group)	Homo sapiens	41-51
34237174-2	2021	Increased arginase 1 activity leads to reduced nitric oxide (NO) production and increased formation of reactive oxygen species due to uncoupling of the NO-producing enzyme endothelial NO synthase (eNOS).	Oxygen	112-118	nitric oxide synthase 3	Homo sapiens	197-201
34107511-8	2021	VO2peak decreased from 35+-6 to 31+-6 ml min-1 kg-1, P<0.001) in women and from 35+-9 to 32+-9 ml min-1 kg-1 (P=0.024) in men in approximate proportion to the reduction of O2 carrying capacity, an effect that did not differ between sexes (P=0.778).	Oxygen	172-174	CD59 molecule (CD59 blood group)	Homo sapiens	98-108
34583309-1	2021	TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator (TIGAR) belongs to the phosphatases family of proteins that modulates the level of reactive oxygen species in tumor cells.	Oxygen	159-165	tumor protein p53	Homo sapiens	0-4
34583309-1	2021	TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator (TIGAR) belongs to the phosphatases family of proteins that modulates the level of reactive oxygen species in tumor cells.	Oxygen	159-165	tumor protein p53	Homo sapiens	6-22
34428557-16	2021	After only 4 weeks on high-fat diet, female LEAP2-KO mice exhibited lower O2 consumption (by 13%), heat production (by 9.5%), and locomotor activity (by 49%) than wild-type littermates during the first part of the dark period.	Oxygen	74-76	liver-expressed antimicrobial peptide 2	Mus musculus	44-49
34399404-4	2021	Likewise, the decrease in the transcription factor NRF2, owing to exacerbated production of reactive oxygen species, leads to changes in immune function and response to infections.	Oxygen	101-107	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
34916718-10	2021	Our findings suggest that reduced serum albumin levels enhance the production of oxygen-derived free radicals, resulting in impaired maternal vascular endothelial function in parturients with PE.	Oxygen	81-87	albumin	Homo sapiens	40-47
34757278-8	2021	Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation.	Oxygen	145-151	interleukin 6	Homo sapiens	84-88
34487922-3	2021	Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27.	Oxygen	136-142	Bardet-Biedl syndrome 9	Homo sapiens	28-32
34487922-3	2021	Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27.	Oxygen	209-215	Bardet-Biedl syndrome 9	Homo sapiens	28-32
34459035-7	2021	After truncating HIF1alpha to its Carboxy-terminal Oxygen-Dependent Degradation (CODD) domain, we showed that pevonedistat inhibited the degradation of CODD and increased its half-life by six-fold in HEK293 cells.	Oxygen	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-26
34634500-2	2021	The ROX index (ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate) has been evaluated to predict success of HFNC in patients with pneumonia.	Oxygen	60-66	MAX network transcriptional repressor	Homo sapiens	4-7
34757278-8	2021	Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation.	Oxygen	145-151	interferon gamma	Homo sapiens	90-99
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	vascular endothelial growth factor A	Homo sapiens	74-108
34656823-7	2021	For example, Ndufs2, a Complex I subunit containing an Fe-S center, N2, has recently been identified as a redox-sensitive oxygen sensor, mediating homeostatic oxygen-sensing in the pulmonary vasculature and carotid body.	Oxygen	122-128	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	13-19
34656823-7	2021	For example, Ndufs2, a Complex I subunit containing an Fe-S center, N2, has recently been identified as a redox-sensitive oxygen sensor, mediating homeostatic oxygen-sensing in the pulmonary vasculature and carotid body.	Oxygen	159-165	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	13-19
34481229-5	2021	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.	Oxygen	480-486	mechanistic target of rapamycin kinase	Homo sapiens	301-330
34481229-5	2021	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.	Oxygen	480-486	mechanistic target of rapamycin kinase	Homo sapiens	332-336
34711689-2	2021	The hypoxia-inducible factor-1alpha (HIF-1alpha) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-35
34711689-2	2021	The hypoxia-inducible factor-1alpha (HIF-1alpha) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
34711703-0	2021	BMP-6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway.	Oxygen	17-23	bone morphogenetic protein 6	Homo sapiens	0-5
34711703-4	2021	The present study was aimed to investigate whether BMP-6 could protect human NSCs (hNSCs) against the oxygen and glucose deprivation (OGD)-induced cell death.	Oxygen	102-108	bone morphogenetic protein 6	Homo sapiens	51-56
34605540-5	2021	Here we show that BACH1 may have a dual effect on CFTR expression by direct occupancy of CREs at physiological oxygen (~8%), while indirectly modulating expression under conditions of oxidative stress.	Oxygen	111-117	BTB domain and CNC homolog 1	Homo sapiens	18-23
34605540-5	2021	Here we show that BACH1 may have a dual effect on CFTR expression by direct occupancy of CREs at physiological oxygen (~8%), while indirectly modulating expression under conditions of oxidative stress.	Oxygen	111-117	CF transmembrane conductance regulator	Homo sapiens	50-54
34547902-14	2021	CMA of SG-eNOS terminates O2 - generation preventing further tissue damage but causes irreversible loss of eNOS and NO availability.	Oxygen	26-28	nitric oxide synthase 3	Homo sapiens	10-14
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	vascular endothelial growth factor A	Homo sapiens	110-114
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	tumor necrosis factor	Homo sapiens	152-179
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	tumor necrosis factor	Homo sapiens	181-185
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	interleukin 2	Homo sapiens	188-191
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	interleukin 4	Homo sapiens	193-196
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Oxygen	161-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34769027-2	2021	Cells respond to oxygen deprivation by activating cytoprotective programs, such as mitochondrial connexin43 (mCx43) overexpression and the opening of mitochondrial KATP channels, aimed to reduce mitochondrial dysfunction.	Oxygen	17-23	gap junction protein, alpha 1	Rattus norvegicus	97-107
34636556-4	2021	It is particularly noteworthy that SOD can effectively catalyze dismutation of the  O2- to produce H2O2 and O2, and Au@PANI with a good reduction and catalytic property can catalyze the produced H2O2 into H2O and O2.	Oxygen	84-86	superoxide dismutase 1	Homo sapiens	35-38
34636556-4	2021	It is particularly noteworthy that SOD can effectively catalyze dismutation of the  O2- to produce H2O2 and O2, and Au@PANI with a good reduction and catalytic property can catalyze the produced H2O2 into H2O and O2.	Oxygen	108-110	superoxide dismutase 1	Homo sapiens	35-38
34636556-4	2021	It is particularly noteworthy that SOD can effectively catalyze dismutation of the  O2- to produce H2O2 and O2, and Au@PANI with a good reduction and catalytic property can catalyze the produced H2O2 into H2O and O2.	Oxygen	213-215	superoxide dismutase 1	Homo sapiens	35-38
34765603-6	2021	Mechanistically, PGLS inhibition repressed the PPP, resulting in increased reactive oxygen species level that decreased proliferation and metastasis and increased apoptosis in HCC cells.	Oxygen	84-90	6-phosphogluconolactonase	Homo sapiens	17-21
34764873-7	2021	In vitro, the cultured H9c2 cells or cardiac fibroblasts were exposed to 3% O2 for 48 h to induce hypertrophy or fibrosis, which showed hypertrophic (increases in cellular size as well as the expression of ANP and BNP) or fibrotic features (increases in the expression of collagen I, collagen III, and alpha-SMA).	Oxygen	76-78	natriuretic peptide B	Rattus norvegicus	214-217
34734081-2	2021	The objective of this study was to analyze the association between the serum S100B protein, the Gosling pulsatility index (PI), and the level of oxygen saturation at the tip of the internal jugular vein (SjVO2%) in patients diagnosed with severe TBI.	Oxygen	145-151	S100 calcium binding protein B	Homo sapiens	77-82
34581315-5	2021	We propose an enzymatic method that liquefies samples by means of generating O2 bubbles with endogenous catalase.	Oxygen	77-79	catalase	Homo sapiens	104-112
34827571-7	2021	Ultimately, adiponectin deficiency restored mifepristone-decreased oxygen consumption and suppressed the expression of thermogenic genes in inguinal fat.	Oxygen	67-73	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
34667156-8	2021	Importantly, DEX-induced reactive oxygen species production, oxidative injury, and cell apoptosis were significantly attenuated by miR-4523 overexpression in human osteoblasts and hFOB1.19 cells.	Oxygen	34-40	microRNA 4523	Homo sapiens	131-139
34834615-8	2021	We determined that ALS INTERACTING PROTEIN1 (AIP1), which encodes the small subunit of ALS, is strongly expressed in all organs and highly expressed under submergence and low-oxygen stresses.	Oxygen	175-181	highly ABA-induced PP2C protein 2	Arabidopsis thaliana	19-43
34834615-8	2021	We determined that ALS INTERACTING PROTEIN1 (AIP1), which encodes the small subunit of ALS, is strongly expressed in all organs and highly expressed under submergence and low-oxygen stresses.	Oxygen	175-181	highly ABA-induced PP2C protein 2	Arabidopsis thaliana	45-49
34834615-9	2021	We also showed that the overexpression of AIP1 confers tolerance to low-oxygen stress.	Oxygen	72-78	highly ABA-induced PP2C protein 2	Arabidopsis thaliana	42-46
34720748-9	2021	The O2 + PBS mice exhibited significantly higher kidney injury scores, 8-hydroxy-2"-deoxyguanosine (8-OHdG) and nuclear factor-kappaB (NF-kappaB) expression, and cytokine levels than did the RA + PBS mice or RA + anti-Tn mice.	Oxygen	4-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-133
34720748-9	2021	The O2 + PBS mice exhibited significantly higher kidney injury scores, 8-hydroxy-2"-deoxyguanosine (8-OHdG) and nuclear factor-kappaB (NF-kappaB) expression, and cytokine levels than did the RA + PBS mice or RA + anti-Tn mice.	Oxygen	4-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
34686682-2	2021	Hypoxia-inducible factor 1alpha (HIF1alpha) predominantly mediates the adaptive response to O2 oscillation and is linked to multiple malignant hallmarks.	Oxygen	92-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
34686682-2	2021	Hypoxia-inducible factor 1alpha (HIF1alpha) predominantly mediates the adaptive response to O2 oscillation and is linked to multiple malignant hallmarks.	Oxygen	92-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-42
34768786-2	2021	Regulation of glycolysis is mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor that responds to local oxygen tension.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-71
34768786-2	2021	Regulation of glycolysis is mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor that responds to local oxygen tension.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
34746011-6	2021	Simultaneously, the dual glutathione oxidase (GSH-OXD) and catalase (CAT) activities of the SFO nanozyme significantly lowered the content of GSH in tumor tissues and efficiently catalyzed the conversion of intracellular hydrogen peroxide to produce a large amount of oxygen (O2) for intracellular redox homeostasis disruption, thus reducing radiotherapy resistance.	Oxygen	268-274	catalase	Homo sapiens	59-67
34746011-6	2021	Simultaneously, the dual glutathione oxidase (GSH-OXD) and catalase (CAT) activities of the SFO nanozyme significantly lowered the content of GSH in tumor tissues and efficiently catalyzed the conversion of intracellular hydrogen peroxide to produce a large amount of oxygen (O2) for intracellular redox homeostasis disruption, thus reducing radiotherapy resistance.	Oxygen	268-274	catalase	Homo sapiens	69-72
34746011-6	2021	Simultaneously, the dual glutathione oxidase (GSH-OXD) and catalase (CAT) activities of the SFO nanozyme significantly lowered the content of GSH in tumor tissues and efficiently catalyzed the conversion of intracellular hydrogen peroxide to produce a large amount of oxygen (O2) for intracellular redox homeostasis disruption, thus reducing radiotherapy resistance.	Oxygen	276-278	catalase	Homo sapiens	59-67
34746011-6	2021	Simultaneously, the dual glutathione oxidase (GSH-OXD) and catalase (CAT) activities of the SFO nanozyme significantly lowered the content of GSH in tumor tissues and efficiently catalyzed the conversion of intracellular hydrogen peroxide to produce a large amount of oxygen (O2) for intracellular redox homeostasis disruption, thus reducing radiotherapy resistance.	Oxygen	276-278	catalase	Homo sapiens	69-72
34805785-4	2021	CLS and cardiac CL species were significantly downregulated in cardiomyocytes following catecholamine-induced cardiac damage in mice, accompanied by increased oxygen consumption rates, signs of oxidative stress, and mitochondrial uncoupling.	Oxygen	159-165	cardiolipin synthase 1	Mus musculus	0-3
34736121-5	2021	At the molecular level, metformin inhibits an inflammatory program executed by HIF1alpha in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner.	Oxygen	209-215	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-88
34585569-6	2021	The oxygen permeability (OP) of the 1D crystalline PVOH/Hec is an order of magnitude lower compared to the OP of the disordered nanocomposite at this elevated RH (OP = 0.007 cm3 mum m-2 day-1 bar-1 cf.	Oxygen	4-10	NDC80 kinetochore complex component	Homo sapiens	56-59
34557899-3	2021	In a translational hyperoxia model, exposing mice pups at age P5 to 80% oxygen for 48 hours to mimic a steep rise of oxygen exposure caused by preterm birth from in utero into room air, we documented a persistent reduction of cortical mature parvalbumin expressing interneurons until adulthood.	Oxygen	72-78	parvalbumin	Mus musculus	242-253
34557899-3	2021	In a translational hyperoxia model, exposing mice pups at age P5 to 80% oxygen for 48 hours to mimic a steep rise of oxygen exposure caused by preterm birth from in utero into room air, we documented a persistent reduction of cortical mature parvalbumin expressing interneurons until adulthood.	Oxygen	117-123	parvalbumin	Mus musculus	242-253
34691356-0	2021	Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells.	Oxygen	53-59	NAD(P)H quinone dehydrogenase 1	Homo sapiens	44-48
34691356-9	2021	In summary, our data support a protective role for human NQO1 against oxygen-mediated toxicity and oxidative DNA lesions in human pulmonary cells, and protection against toxicity was partially lost in SNP cells.	Oxygen	70-76	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61
34648132-6	2021	Furthermore, a lack of miR-7-5p expression led to increased levels of transferrin receptor, promoting the uptake of iron and production of lipid reactive oxygen species and demonstrating that DOX-induced ferroptosis occurs in AC16 cells.	Oxygen	154-160	microRNA 7-2	Homo sapiens	23-31
34721028-6	2021	Treatment with the extract (12.5, 25, and 50 mug/ml) prevented Ang II-induced increases in cell size, NADPH oxidase activity, B-type natriuretic peptide levels, and reactive oxygen species and reductions in superoxide dismutase activity.	Oxygen	174-180	angiotensinogen	Rattus norvegicus	63-69
34681140-3	2021	An increase in circulating angiotensin-II is a potent stimulus for the expression of reactive oxygen species and pro-inflammatory cytokines that activate oxidative stress, perpetuating a deleterious effect in hypertension.	Oxygen	94-100	angiotensinogen	Homo sapiens	27-41
34519734-0	2021	Field-induced single-ion magnet based on a quasi-octahedral Co(II) complex with mixed sulfur-oxygen coordination environment.	Oxygen	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
34519734-2	2021	X-ray diffraction studies reveal the first coordination sphere of the Co(II) ion, consisting of two chelating tridentate TDA ligands with a mixed sulfur-oxygen strongly elongated octahedral coordination environment.	Oxygen	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Oxygen	92-98	catalase	Mus musculus	0-8
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Oxygen	92-98	catalase	Mus musculus	10-13
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Oxygen	100-102	catalase	Mus musculus	0-8
34684730-3	2021	Catalase (CAT) can degrade hydrogen peroxide so that it produces less toxic water (H2O) and oxygen (O2) in order to reduce the harm caused by H2O2.	Oxygen	100-102	catalase	Mus musculus	10-13
34754682-8	2021	Results Multivariate and univariate linear regression modeling on this population cohort was remarkable for a significant association between serum albumin levels and oxygen escalation or de-escalation from NIPPV.	Oxygen	167-173	albumin	Homo sapiens	148-155
34416529-0	2021	A numerical bone regeneration model incorporating angiogenesis, considering oxygen-induced secretion of vascular endothelial growth factor and vascular remodeling.	Oxygen	76-82	vascular endothelial growth factor A	Homo sapiens	104-138
34416529-3	2021	In this paper, we propose a bone regeneration model with angiogenesis based on the theories of mechanobiology regulation, vascular network modeling, oxygen-induced secretion of vascular endothelial growth factor (VEGF), and vascular remodeling.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	177-211
34416529-3	2021	In this paper, we propose a bone regeneration model with angiogenesis based on the theories of mechanobiology regulation, vascular network modeling, oxygen-induced secretion of vascular endothelial growth factor (VEGF), and vascular remodeling.	Oxygen	149-155	vascular endothelial growth factor A	Homo sapiens	213-217
34627276-5	2021	Specifically, MRp NCs decompose in TME, meanwhile they deprived the endogenous expression of survivin gene and significantly amplified the generation of reactive oxygen species after exposure to LED light, resulting in serious tumor destruction.	Oxygen	162-168	ATP binding cassette subfamily C member 1	Homo sapiens	14-17
34627276-5	2021	Specifically, MRp NCs decompose in TME, meanwhile they deprived the endogenous expression of survivin gene and significantly amplified the generation of reactive oxygen species after exposure to LED light, resulting in serious tumor destruction.	Oxygen	162-168	small integral membrane protein 10 like 2A	Homo sapiens	195-198
34692754-4	2021	In this study, we obtained a fat-soluble extract from Chlorella (CE) and demonstrated that it reduced NLRP3 inflammasome activation by inhibiting mitochondrial reactive oxygen species and caspase-1 activation.	Oxygen	169-175	NLR family pyrin domain containing 3	Homo sapiens	102-107
34621018-1	2021	Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
34621018-1	2021	Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
34416529-4	2021	The results showed that this model can describe the distribution and concentration of vascular endothelial growth factor induced by oxygen tension during bone regeneration, the growth and remodeling of vascular tissue under the influence of vascular endothelial growth factor and mechanical loading, and the correspondence between vascular tissue and bone regeneration.	Oxygen	132-138	vascular endothelial growth factor A	Homo sapiens	86-120
34690806-0	2021	Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis.	Oxygen	95-101	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
34690806-0	2021	Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis.	Oxygen	95-101	stromal interaction molecule 1	Homo sapiens	110-140
34659696-6	2021	The expression intensity of HIF-1alpha and VEGF decreased gradually, HIF-1alpha was positively correlated with VEGF (r = 0.98, P < 0.01), there was a negative correlation between oxygen partial pressure and HIF-1 alpha expression (r = -0.92, P < 0.01), and it was negatively correlated with VEGF (r = -0.88, P < 0.01).	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
34659696-6	2021	The expression intensity of HIF-1alpha and VEGF decreased gradually, HIF-1alpha was positively correlated with VEGF (r = 0.98, P < 0.01), there was a negative correlation between oxygen partial pressure and HIF-1 alpha expression (r = -0.92, P < 0.01), and it was negatively correlated with VEGF (r = -0.88, P < 0.01).	Oxygen	179-185	vascular endothelial growth factor A	Homo sapiens	43-47
34639137-2	2021	The activity of the RyR is regulated by the changes in the level of many intracellular factors, such as divalent cations (Ca2+ and Mg2+), nucleotides, associated proteins, and reactive oxygen species.	Oxygen	185-191	ryanodine receptor 1	Homo sapiens	20-23
34754682-9	2021	Conclusions We conclude that serum albumin level may have further utility in predicting oxygen escalation in pre-intubated patients with SARS-CoV-2, especially in a low-resource and high-demand setting.	Oxygen	88-94	albumin	Homo sapiens	35-42
34659696-6	2021	The expression intensity of HIF-1alpha and VEGF decreased gradually, HIF-1alpha was positively correlated with VEGF (r = 0.98, P < 0.01), there was a negative correlation between oxygen partial pressure and HIF-1 alpha expression (r = -0.92, P < 0.01), and it was negatively correlated with VEGF (r = -0.88, P < 0.01).	Oxygen	179-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	207-218
34659696-7	2021	TcPO2 measurement can be used to assess scar maturity; HIF-1 alpha and VEGF may play an essential role in regulating partial oxygen pressure in the scar tissue.	Oxygen	125-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-66
34676163-12	2021	PGCCs also produced embryonic hemoglobin-delta and -zeta with strong oxygen-binding ability and erythroid differentiation-related proteins after ATO treatment.	Oxygen	69-75	hemoglobin subunit delta	Homo sapiens	30-56
34659696-7	2021	TcPO2 measurement can be used to assess scar maturity; HIF-1 alpha and VEGF may play an essential role in regulating partial oxygen pressure in the scar tissue.	Oxygen	125-131	vascular endothelial growth factor A	Homo sapiens	71-75
34692682-5	2021	We found that klf9 -/- mutants have a decreased oxygen consumption rate (OCR) and upregulate glycolytic genes, the promoter regions of which are enriched for potential Klf9 binding motifs.	Oxygen	48-54	Kruppel-like factor 9	Danio rerio	14-18
34692682-5	2021	We found that klf9 -/- mutants have a decreased oxygen consumption rate (OCR) and upregulate glycolytic genes, the promoter regions of which are enriched for potential Klf9 binding motifs.	Oxygen	48-54	Kruppel-like factor 9	Danio rerio	168-172
34583520-4	2021	Reactive oxygen species were acutely evoked by exposure of isolated cardiac myocytes to AngII (angiotensin II, 1 micromol/L).	Oxygen	9-15	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	88-93
34583520-4	2021	Reactive oxygen species were acutely evoked by exposure of isolated cardiac myocytes to AngII (angiotensin II, 1 micromol/L).	Oxygen	9-15	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	95-109
34676249-8	2021	After controlling for confounders, TNF-alpha was negatively correlated with the average oxygen saturation (r = -0.258, P = 0.043).	Oxygen	88-94	tumor necrosis factor	Homo sapiens	35-44
34390206-1	2021	Utilizing catalase-mimicking nanozymes to produce O2 is an effective method to overcome tumor hypoxia.	Oxygen	50-52	catalase	Homo sapiens	10-18
34520201-2	2021	Single-crystal diffraction shows the presence of (CO4)4- groups, i.e., sp3-hybridized carbon tetrahedrally coordinated by covalently bound oxygen atoms.	Oxygen	139-145	Sp3 transcription factor	Canis lupus familiaris	71-74
34390206-7	2021	PTZCs inherit the catalase activity of Pd@TiO2 to facilitate the decomposition of endogenous H2 O2 to O2 , which can relieve tumor hypoxia and propel PTZC migration to expand the reach of PTZCs, further enhancing its synergistic treatment outcome both in vitro and in vivo.	Oxygen	102-104	catalase	Homo sapiens	18-26
34102577-6	2021	An increase in neuromuscular activity of the external obliques and an increase change in total oxygen index (%TOI) values in the gastrocnemius were also found using the AC1, however the difference was not much higher than the NAC and AC2.	Oxygen	95-101	adenylate cyclase 1	Homo sapiens	169-172
34323115-7	2021	These findings reveal how low doses of oxygen that do not durably change lung function may prime it for hyperreactive airways disease by changing expression of genes, such as TSP-1, thus helping to explain why former preterm infants who have normal lung function are susceptible to airway obstruction and increased morbidity after viral infection.	Oxygen	39-45	thrombospondin 1	Homo sapiens	175-180
34426261-5	2021	RESULTS: We revealed that, in the non-invasive MCF10DCIS cells but not in the post-EMT MCF7 cells, low oxygen availability induced the decrease of E-cadherin and the increase of vimentin and motility, that were prevented by GE administration.	Oxygen	103-109	cadherin 1	Homo sapiens	147-157
34790731-12	2021	GSVA results showed that nuclear factor interleukin-3 (NFIL3) was related to tumor necrosis factor alpha (TNF-alpha) signaling via nuclear factor kappa-B (NF-kappaB), the reactive oxygen species pathway, and myelocytomatosis (MYC) targets v2.	Oxygen	180-186	nuclear factor, interleukin 3 regulated	Homo sapiens	25-53
34790731-12	2021	GSVA results showed that nuclear factor interleukin-3 (NFIL3) was related to tumor necrosis factor alpha (TNF-alpha) signaling via nuclear factor kappa-B (NF-kappaB), the reactive oxygen species pathway, and myelocytomatosis (MYC) targets v2.	Oxygen	180-186	nuclear factor, interleukin 3 regulated	Homo sapiens	55-60
34790731-12	2021	GSVA results showed that nuclear factor interleukin-3 (NFIL3) was related to tumor necrosis factor alpha (TNF-alpha) signaling via nuclear factor kappa-B (NF-kappaB), the reactive oxygen species pathway, and myelocytomatosis (MYC) targets v2.	Oxygen	180-186	tumor necrosis factor	Homo sapiens	77-104
34790731-12	2021	GSVA results showed that nuclear factor interleukin-3 (NFIL3) was related to tumor necrosis factor alpha (TNF-alpha) signaling via nuclear factor kappa-B (NF-kappaB), the reactive oxygen species pathway, and myelocytomatosis (MYC) targets v2.	Oxygen	180-186	tumor necrosis factor	Homo sapiens	106-115
34903150-2	2021	Lack of oxygen activates the signaling pathway of the hypoxia-inducible transcription factor HIF in cells that has three isoforms, HIF-1, HIF-2, HIF-3, regulating expression of several thousand genes.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-136
34596045-1	2021	Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1alpha stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second messenger peroxide.	Oxygen	194-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-130
34596045-1	2021	Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1alpha stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second messenger peroxide.	Oxygen	229-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-130
34447462-7	2021	By inhibiting HIF-1alpha, miR-18a-5p suppressed aerobic glycolysis in K562/ADM cells, according to the results produced by glucose uptake, lactate production, pyruvate level and ATP synthesis measurement, along with the results obtained from extracellular acidification rate and oxygen consumption rate assays.	Oxygen	279-285	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
34551158-9	2021	More importantly, forced overexpression of oxygen stable form of HIF1alpha completely reversed attenuated pro-inflammatory and glycolytic gene expression in BHLHE40-deficient macrophages.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-74
34302634-0	2021	Lactucin induces apoptosis through reactive oxygen species-mediated BCL-2 and CFLARL downregulation in Caki-1 cells.	Oxygen	44-50	BCL2 apoptosis regulator	Homo sapiens	68-73
34369038-0	2021	Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone.	Oxygen	24-30	growth hormone releasing hormone	Homo sapiens	80-112
34175740-10	2021	Taken together, novel ultrasmall mesoporous Ce-BGn showed remarkable catalase-mimic activity via surface containing Ce3+/Ce4+ ions which can scavenge ROS (Ce3+  Ce4+) and decompose H2O2 molecules into H2O and O2.	Oxygen	209-211	biglycan	Homo sapiens	47-50
34776166-9	2021	RESULTS: The NMES group obtained higher values of ISO, 21.04% (p = 0.001), CON, 21.97% (p = 0.001) and ECC, 18.74% (p = 0.001) peak torque and VAT1, 9.56% (p = 0.001), as well as a statistically significant improvement in oxygen cost of transport at VAT1 when compared to controls (p = 0.001).	Oxygen	222-228	vesicle amine transport 1	Homo sapiens	250-254
34352714-1	2021	In this research article, we describe the Cu-promoted intramolecular hydroxylation of sp2 and sp3 CH bonds using directing groups with varying denticity (bi-, tri- and tetradentate) and natural oxidants (O2 and H2O2).	Oxygen	204-206	Sp2 transcription factor	Homo sapiens	86-89
34098395-10	2021	MAIN RESULTS: Fibrinogen significantly decreased the volume of blood loss (p < 0.001) and the total number of transfused packed-cell units per group (38 vs. 115 units); and compensated the decrease of HCO3 (p = 0.030), the mean arterial pressure (p < 0.001), hemoglobin O2 saturation (p = 0.001), heart rate (p < 0.001), and temperature (p < 0.001) throughout the surgery compared with the placebo.	Oxygen	270-272	fibrinogen beta chain	Homo sapiens	14-24
34352714-1	2021	In this research article, we describe the Cu-promoted intramolecular hydroxylation of sp2 and sp3 CH bonds using directing groups with varying denticity (bi-, tri- and tetradentate) and natural oxidants (O2 and H2O2).	Oxygen	204-206	Sp3 transcription factor	Homo sapiens	94-97
33642395-7	2021	Additionally, it attenuated oxygen and glucose deprivation-induced changes in the expression of the PTEN/AKT signaling pathway as well as synaptic plasticity-related proteins in the neurons.	Oxygen	28-34	AKT serine/threonine kinase 1	Homo sapiens	105-108
34343653-0	2021	Expression of miR-200c corresponds with increased reactive oxygen species and hypoxia markers after transient focal ischemia in mice.	Oxygen	59-65	microRNA 200c	Mus musculus	14-22
34215069-3	2021	Due to the oxidase-mimic catalytic efficiency of nanoceria and the oxygen consumption for glucose oxidation, the photoexcited electrons at the conduction band of g-C3N4 could be well transferred to that of TNA under visible light irradiation, resulting in the increase of the photocurrent of TNA/g-C3N4/nanoceria, and the increase value of photocurrent had a linear relationship with the concentration of thrombin under the optimal conditions.	Oxygen	67-73	coagulation factor II, thrombin	Homo sapiens	405-413
34514698-7	2021	In addition, this layer shows loose and uniformly distributed electrostatic interaction between Li+ and charge delocalized sp3 boron-oxygen anions, which aids to form a uniform intermolecular Li+ path regulating the homogeneous distribution of Li+ flux on Li anodes.	Oxygen	133-139	Sp3 transcription factor	Homo sapiens	123-126
34532978-0	2021	Catalase Nanocrystals Loaded with Methylene Blue as Oxygen Self-Supplied, Imaging-Guided Platform for Photodynamic Therapy of Hypoxic Tumors.	Oxygen	52-58	catalase	Homo sapiens	0-8
34532978-3	2021	Herein, catalase nanocrystals (CatCry) are introduced as in situ oxygen (O2 )-generating system to relieve tumor hypoxia and enhance PDT efficiency for solid tumors.	Oxygen	65-71	catalase	Homo sapiens	8-16
34532978-3	2021	Herein, catalase nanocrystals (CatCry) are introduced as in situ oxygen (O2 )-generating system to relieve tumor hypoxia and enhance PDT efficiency for solid tumors.	Oxygen	73-75	catalase	Homo sapiens	8-16
34494034-1	2021	In the presence of dioxygen, an antimony trichloride enabled conjunctive sp3 C-H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields.	Oxygen	19-27	Sp3 transcription factor	Homo sapiens	73-76
34500180-9	2021	These findings highlight that combining distal geomorphic and hydrologic drivers can be effective in determining the relationship between riverine CH4 and the proximal controls (e.g., nutrients, dissolved oxygen, dissolved organic carbon), as well as in identifying their key drivers.	Oxygen	205-211	COP9 signalosome subunit 4	Drosophila melanogaster	147-150
34592996-3	2021	RESULTS: The results showed that TPZ/PFA@UiO-66@PDA nanoparticles significantly enhanced hypoxia, induced cell apoptosis in vitro through the oxygen-dependent HIF-1alpha pathway and decreased oxygen levels in vivo after intratumoral injection.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
34556343-10	2021	Among clinical symptoms, dyspnea and anosmia were frequent, and in laboratory parameters, neutrophil lymphocyte ratio, high-sensitivity C-reactive protein, and D-dimer were higher in patients requiring oxygen.	Oxygen	202-208	C-reactive protein	Homo sapiens	136-154
34627424-0	2021	(beta-arrestin1 Promotes the Concentration of Mitochondrial Reactive Oxygen in T-ALL Cells via MiR-652-5p).	Oxygen	69-75	arrestin beta 1	Homo sapiens	1-15
34587716-0	2021	Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis.	Oxygen	56-62	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	19-23
34490870-2	2021	The existence of the target malathion would open the catalase-3D network and lots of catalase was released from the hydrogel, which could efficiently convert H2O2 to an O2 molecule.	Oxygen	169-171	catalase	Homo sapiens	85-93
34544857-3	2021	IL-6 blockade repressed the proliferation and migration of TSC2-deficient cells and reduced oxygen consumption and extracellular acidification.	Oxygen	92-98	interleukin 6	Homo sapiens	0-4
34548395-6	2021	An increased level of luminal ATP in the colon of Entpd8 -/- mice promotes glycolysis in neutrophils through P2x4 receptor-dependent Ca2+ influx, which is linked to prolonged survival and elevated reactive oxygen species production in these cells.	Oxygen	206-212	ectonucleoside triphosphate diphosphohydrolase 8	Mus musculus	50-56
34646161-0	2021	Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery.	Oxygen	54-60	erythropoietin	Homo sapiens	74-88
34646161-2	2021	Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined.	Oxygen	38-44	erythropoietin	Homo sapiens	100-103
34646161-1	2021	The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia.	Oxygen	16-22	erythropoietin	Homo sapiens	104-118
34646161-8	2021	Percentage EPO at day nine with respect to the baseline value was significantly elevated within the groups (O2 group: 323.7 (SD +- 139.0); control group: 365.6 (SD+- 162.0)) but not between them.	Oxygen	108-110	erythropoietin	Homo sapiens	11-14
34646161-1	2021	The "Normobaric Oxygen Paradox" (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia.	Oxygen	16-22	erythropoietin	Homo sapiens	120-123
34562089-6	2022	DOX activates nicotinamide adenine dinucleotide phosphate NADPH oxidase (NOX) in the heart, resulting in excessive reactive oxygen species that can induce cardiomyocyte apoptosis through phosphorylation of p53, DNA damage and/or mitogen-activated protein kinases-mediated cardiomyocyte apoptosis.	Oxygen	124-130	tumor protein p53	Homo sapiens	206-209
34684945-5	2021	The 2D-VRH conduction originates from structural disorder and is consistent with hopping of charge carriers between sp2 defects in the plane, where sp3 clusters related to oxygen functional groups act as potential barriers.	Oxygen	172-178	Sp2 transcription factor	Homo sapiens	116-119
34684945-5	2021	The 2D-VRH conduction originates from structural disorder and is consistent with hopping of charge carriers between sp2 defects in the plane, where sp3 clusters related to oxygen functional groups act as potential barriers.	Oxygen	172-178	Sp3 transcription factor	Homo sapiens	148-151
34175393-2	2021	HIF-1alpha acts differently depending on presence or absence of Oxygen.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
34175393-3	2021	In an oxygen-immersed environment, HIF-1alpha completely deactivated and destroyed by the ubiquitin proteasome pathway (UPP).	Oxygen	6-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
34638542-4	2021	This study investigates the mechanism of NFkappaB activation in a first trimester trophoblastic cell line (HTR8/SVneo) stimulated by a medium containing serum from preeclamptic (PE) or normotensive (C) women in hypoxic (2% O2) or normoxic (8% O2) conditions.	Oxygen	223-225	nuclear factor kappa B subunit 1	Homo sapiens	41-49
34611552-3	2021	Because, there is the strict coupling between the pyrimidine synthesis and the mitochondrial respiratory chain, the oxygen level could modify the cytostatic TNF effect.	Oxygen	116-122	tumor necrosis factor	Homo sapiens	157-160
34611552-11	2021	Thus, it gives assumption for future comprehensive studies at real oxygen environment involving TNF use in combination with other antitumor agents affecting oxygen-dependent pyrimidine synthesis.	Oxygen	67-73	tumor necrosis factor	Homo sapiens	96-99
34611552-11	2021	Thus, it gives assumption for future comprehensive studies at real oxygen environment involving TNF use in combination with other antitumor agents affecting oxygen-dependent pyrimidine synthesis.	Oxygen	157-163	tumor necrosis factor	Homo sapiens	96-99
34535266-6	2021	O2 - production was synchronized with myeloperoxidase (MPO) activation in the former type but not in the latter.	Oxygen	0-4	myeloperoxidase	Homo sapiens	38-53
34535266-6	2021	O2 - production was synchronized with myeloperoxidase (MPO) activation in the former type but not in the latter.	Oxygen	0-4	myeloperoxidase	Homo sapiens	55-58
34638542-4	2021	This study investigates the mechanism of NFkappaB activation in a first trimester trophoblastic cell line (HTR8/SVneo) stimulated by a medium containing serum from preeclamptic (PE) or normotensive (C) women in hypoxic (2% O2) or normoxic (8% O2) conditions.	Oxygen	243-245	nuclear factor kappa B subunit 1	Homo sapiens	41-49
34638542-5	2021	The results indicate that in HTR8/SVneo cells, the most widely studied NFkappaB pathways, i.e., canonical, non-canonical and atypical, are downregulated in environment PE 2% O2 in comparison to C 8% O2.	Oxygen	174-176	nuclear factor kappa B subunit 1	Homo sapiens	71-79
34534345-1	2021	BACKGROUND: The non-transferrin bound catalytic iron moiety catalyses production of toxic reactive oxygen species and is associated with adverse outcomes.	Oxygen	99-105	transferrin	Homo sapiens	20-31
34621741-6	2021	Our results demonstrate severe hypoxic stress (0.1% oxygen) caused ATM auto-phosphorylation and activation (pS1981), H3K9me3, and elevated both Suv39H1 and Tip60 protein levels in FTC133 and HCT116 cell lines.	Oxygen	52-58	SUV39H1 histone lysine methyltransferase	Homo sapiens	144-151
34538802-11	2022	CONCLUSIONS: The presence of CP in nonsyndromic PRS patients decreases the severity of obstructive sleep apnea by oxygen parameters on PSG.	Oxygen	114-120	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	135-138
34603086-2	2021	Methods: Training data from 19 high-level rowers (age 23.5 +- 5.9 years; maximal oxygen uptake 58.9 +- 5.8 ml min-1 kg-1) were collected during a 4-week volume increased training period.	Oxygen	81-87	CD59 molecule (CD59 blood group)	Homo sapiens	110-120
34612275-4	2021	They induce a directed and tunable charge relocation mechanism from deep Co to topmost Pt to optimize the adsorption energies of O2/O* and achieve excellent ORR kinetics performance with minimum Pt usage but maximum Pt atom utilization (i.e., Pt1 to Pt3) compared with benchmark Pt(111).	Oxygen	129-131	zinc finger protein 135	Homo sapiens	250-253
34526485-9	2021	BCKDK silencing in TNBC cells downregulated mitochondrial metabolism genes, reduced electron complex protein expression, oxygen consumption, and ATP production.	Oxygen	121-127	branched chain keto acid dehydrogenase kinase	Homo sapiens	0-5
34102366-1	2021	We prepared a single-atom Fe catalyst supported on an oxygen-doped, nitrogen-rich carbon support (SAFe-OCN) for degrading a broad spectrum of contaminants of emerging concern (CECs) by activating peroxides such as peroxymonosulfate (PMS).	Oxygen	54-60	bone gamma-carboxyglutamate protein	Homo sapiens	103-106
34102366-4	2021	Specifically, SAFe-OCN, with a catalytic center of Fe coordinated with both nitrogen and oxygen (FeNxO4-x), showed 5.13-times increased phenol degradation kinetics upon activating PMS compared to the catalyst where Fe was only coordinated with nitrogen (FeN4).	Oxygen	89-95	bone gamma-carboxyglutamate protein	Homo sapiens	19-22
34577080-3	2021	Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H2O2 to form O2, thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen (1O2) production with infrared irradiation.	Oxygen	124-126	catalase	Homo sapiens	38-41
34133989-0	2021	Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway.	Oxygen	64-70	mitogen-activated protein kinase 14	Homo sapiens	163-166
34133989-3	2021	In this study, we identified that type 4 metabotropic glutamate receptor (mGluR4) was expressed in cultured human NSCs (hNSCs) isolated from the human fetus cortex and further established the oxygen and glucose deprivation (OGD) model in hNSCs to study the role of mGluR4 in hypoxic and ischemic injury.	Oxygen	192-198	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	74-80
34519735-5	2021	Hydrogen peroxide (H2O2) produced by Ag-G/C@M through the consumption of glucose is further catalyzed by CAT to produce oxygen (O2).	Oxygen	120-126	catalase	Homo sapiens	105-108
34519735-5	2021	Hydrogen peroxide (H2O2) produced by Ag-G/C@M through the consumption of glucose is further catalyzed by CAT to produce oxygen (O2).	Oxygen	128-130	catalase	Homo sapiens	105-108
34498647-2	2021	The trimers were found to have moderately low O2 affinity (p50 = 23-34 Torr, 37  C) and high co-operativity, yielding a maximum O2 transport efficiency 1.8-fold higher than that of human RBCs.	Oxygen	46-48	nuclear factor kappa B subunit 1	Homo sapiens	59-62
34498647-2	2021	The trimers were found to have moderately low O2 affinity (p50 = 23-34 Torr, 37  C) and high co-operativity, yielding a maximum O2 transport efficiency 1.8-fold higher than that of human RBCs.	Oxygen	128-130	nuclear factor kappa B subunit 1	Homo sapiens	59-62
34495409-8	2021	PC12 cells deprived of oxygen/glucose developed signs of cellular injury (LDH release and necroptosis) concomitant with downregulation of Pellino3, decreased ubiquitination of RIPK1, and elevated necroptosis-associated proteins.	Oxygen	23-29	pellino E3 ubiquitin protein ligase family member 3	Rattus norvegicus	138-146
34575844-6	2021	We will also discuss the cellular mechanisms used to cope with low oxygen tensions, such as the induction of hypoxia-inducible factor (HIF) or mammalian target of rapamycin (mTOR) signals, regulation of the metabolic pathway, and adaptation to autophagy.	Oxygen	67-73	mechanistic target of rapamycin kinase	Homo sapiens	143-172
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	13-15	catalase	Homo sapiens	72-75
34503051-4	2021	It has been reported often that oxygen permeability (PO2) and oxygen permselectivity (alpha = PO2/PN2) have trade-off relationships for symmetric membranes made from pure polymers.	Oxygen	62-68	amyloid beta precursor protein	Homo sapiens	94-101
34502464-3	2021	Dysfunctional endothelial nitric oxide synthase (eNOS) produces superoxide anion (O2- ) and contributes to the establishment of a pro-oxidant environment in melanoma.	Oxygen	82-85	nitric oxide synthase 3	Homo sapiens	14-47
34502464-3	2021	Dysfunctional endothelial nitric oxide synthase (eNOS) produces superoxide anion (O2- ) and contributes to the establishment of a pro-oxidant environment in melanoma.	Oxygen	82-85	nitric oxide synthase 3	Homo sapiens	49-53
34502464-6	2021	Both treatment with L-sepiapterin and eNOS downregulation induced increased nitric oxide (NO) and decreased O2  levels, triggering NOS coupling and reducing cell growth and resistance to anoikis and dacarbazine chemotherapy.	Oxygen	108-110	nitric oxide synthase 3	Homo sapiens	38-42
34315245-8	2021	Ppm1d-mutant macrophages were impaired in DDR pathway activation and displayed greater DNA damage, higher reactive oxygen species generation and an augmented proinflammatory profile with elevations in IL-1beta and IL-18.	Oxygen	115-121	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	0-5
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	13-15	catalase	Homo sapiens	326-329
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	419-421	catalase	Homo sapiens	72-75
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	419-421	catalase	Homo sapiens	326-329
34225012-1	2021	Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as Hypoxia-Inducible Factor-1 (HIF-1).	Oxygen	26-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-122
34270373-6	2021	Furthermore, Ang II-induced increased levels of superoxide anion (O2-) and NADPH oxidase activity and increased phosphorylation of ERK1/2 and AKT that are implicated in enhanced expression of Gialpha proteins and hyperproliferation of VSMC were also attenuated to control levels by silencing of Sirt1.	Oxygen	66-69	angiotensinogen	Homo sapiens	13-19
34225012-1	2021	Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as Hypoxia-Inducible Factor-1 (HIF-1).	Oxygen	26-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-129
34225012-2	2021	HIF-1 acts as a main transcriptional mediator in the tissue hypoxia response that regulates over 1000 genes related to low oxygen tension.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
34282078-5	2021	Vit C/ascorbic acid stimulates oxygen radical scavenging activity of the skin and enhances epithelial barrier function.	Oxygen	31-37	vitrin	Homo sapiens	0-3
34479975-2	2021	Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation.See related article by Papachristodoulou et al., p. 2316.	Oxygen	116-122	heat shock protein family A (Hsp70) member 9	Homo sapiens	17-22
34183377-6	2021	We compared hAOX1 to the high O2 .- producing natural variant L438V for their time-dependent inactivation with H2O2/O2 .- during substrate turnover.	Oxygen	116-118	aldehyde oxidase 1	Homo sapiens	12-17
34475628-0	2021	The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake.	Oxygen	146-152	solute carrier family 16 member 1	Homo sapiens	4-8
34175385-9	2021	The neuron apoptosis and necrosis rates, and production of reactive oxygen species (ROS) and inflammatory cytokines, including IL-6, IL-8, TNF-alpha, and 8-iso-PGF2alpha, were significantly increased by high glucose stimulation combined with oxygen-glucose deprivation treatment, which were inhibited by 2BFI.	Oxygen	242-248	interleukin 6	Rattus norvegicus	127-131
34175385-9	2021	The neuron apoptosis and necrosis rates, and production of reactive oxygen species (ROS) and inflammatory cytokines, including IL-6, IL-8, TNF-alpha, and 8-iso-PGF2alpha, were significantly increased by high glucose stimulation combined with oxygen-glucose deprivation treatment, which were inhibited by 2BFI.	Oxygen	242-248	tumor necrosis factor	Rattus norvegicus	139-148
34518647-7	2021	The results of this study elucidate the direct molecular mechanisms linking miR-26a/b-5p and Cox5a in cell death induced by oxygen tension, which may contribute to the identification of new therapeutic targets to modulate cardiac function under physiological and pathological conditions.	Oxygen	124-130	cytochrome c oxidase subunit 5A	Rattus norvegicus	93-98
34471141-4	2021	While glycolysis is suppressed by AURKA inhibition, we note an increase in the oxygen consumption rate fueled by enhanced fatty acid oxidation (FAO), which was accompanied by an increase of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha).	Oxygen	79-85	PPARG coactivator 1 alpha	Homo sapiens	260-269
34331963-6	2021	FUNDC1 ablation unmasked HFD-evoked rises in fatty acid synthase ACSL4, necroptosis, inflammation, ferroptosis, mitochondrial O2- production, and mitochondrial injury as well as dampened autophagy and DNA repair enzyme 8-oxoG DNA glycosylase 1 (OGG1) but not apoptosis, the effect of which except ACSL4 and its regulator SP1 was reversed by LIP-1.	Oxygen	126-129	acyl-CoA synthetase long chain family member 4	Homo sapiens	297-302
34296310-5	2021	Genetic knockdown of salusin-beta retarded, whereas overexpression of salusin-beta aggravated, HG-triggered iron overload, antioxidant capability reduction, massive reactive oxygen species production and lipid peroxidation in HK-2 cells.	Oxygen	174-180	torsin family 2 member A	Homo sapiens	70-82
34310962-0	2021	Manganese-induced reactive oxygen species activate IkappaB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro.	Oxygen	27-33	YY1 transcription factor	Homo sapiens	80-83
34310962-0	2021	Manganese-induced reactive oxygen species activate IkappaB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro.	Oxygen	27-33	solute carrier family 1 member 2	Homo sapiens	117-122
34146386-3	2021	Neuroglobin (Ngb) is a protein found in neurons of both the peripheral and central nervous system that appears to convey some resilience to hypoxia, while the hypoxia-inducible factor (Hif-1alpha) is a dimeric protein complex that plays an integral role in the body"s response to low oxygen concentrations, or hypoxia.	Oxygen	284-290	hypoxia inducible factor 1 subunit alpha	Homo sapiens	185-195
34229049-9	2021	The expression of Mfsd2a, the LPC-DHA transporter, was reduced in the oxygen-induced retinopathy (OIR) model and streptozotocin (STZ) model.	Oxygen	70-76	major facilitator superfamily domain containing 2A	Homo sapiens	18-24
34330026-4	2021	The mechanism of SPC activation by CuFeS2 was elucidated, which was discovered to be a multiple reactive oxygen species (multi-ROS) process with the coexistence of hydroxyl radical ( OH), carbonate radical (CO3 -), superoxide radical (O2 -), and singlet oxygen (1O2), as evidenced by quenching experiments and electron spin resonance (ESR) tests.	Oxygen	235-239	surfactant protein C	Homo sapiens	17-20
34218480-6	2021	Consequently, reduced PSII supercomplex accumulation, chlorophyll content per cell, PSII quantum yield and photosynthetic oxygen evolution were measured in the lpa2 mutants, leading to an almost complete impairment of photoautotrophic growth.	Oxygen	122-128	low psii accumulation2	Arabidopsis thaliana	160-164
34214612-4	2021	MATERIALS AND METHODS: In a bottom-up approach starting from the chemical track evolution of 1 MeV electrons in oxygenated water simulated with the TRAX-CHEM Monte Carlo code, we determine the oxygen consumption and radiolytic reactive oxygen species production following a short radiation pulse.	Oxygen	193-199	translin associated factor X	Homo sapiens	148-152
34146386-11	2021	Both Ngb and Hif-1alpha participate in oxygen transports throughout the telencephalon and have functions in neuroprotection.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
34227829-5	2021	The measured apparent Km (Km(app)) values for O2 of selected strains ranged from 37 to 288 nmol O2 liter-1, comparable to values previously assigned to low-affinity TOs.	Oxygen	46-48	amyloid beta precursor protein	Homo sapiens	26-33
34227829-5	2021	The measured apparent Km (Km(app)) values for O2 of selected strains ranged from 37 to 288 nmol O2 liter-1, comparable to values previously assigned to low-affinity TOs.	Oxygen	96-98	amyloid beta precursor protein	Homo sapiens	26-33
34502140-2	2021	In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 PANC-1) that enables time-resolved activation of the NF-kappaB and extracellular-signal regulated kinases (ERK)1/2 signalling pathway upon blue light-sensitive homodimerisation of the TLR4-LOV fusion protein.	Oxygen	41-47	nuclear factor kappa B subunit 1	Homo sapiens	169-178
34453596-2	2021	The results show that the introduction of coordinated oxygen is beneficial to increase the HOF value.	Oxygen	54-60	zinc finger and BTB domain containing 20	Homo sapiens	91-94
34502140-2	2021	In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 PANC-1) that enables time-resolved activation of the NF-kappaB and extracellular-signal regulated kinases (ERK)1/2 signalling pathway upon blue light-sensitive homodimerisation of the TLR4-LOV fusion protein.	Oxygen	41-47	mitogen-activated protein kinase 3	Homo sapiens	183-230
34445747-5	2021	We found hypoxia downregulated the expression of the ACE2 receptor and increased the critical oxygen homeostatic signaling protein, hypoxia-inducible factor (HIF-1alpha); however, treatment of the cells with HbA yielded no apparent change in the levels of ACE2 or HIF-1alpha.	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
34380313-6	2021	In the presence of stronger acids, the activity of the complex containing pendent relays becomes O2 dependent, implying a shift to Co(III)-superoxide protonation as the rate-determining step.	Oxygen	97-99	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	131-138
34502897-8	2021	When TiH2 content is greater than zero and not more than 10%, the chemical reaction mechanism of Al-rich Al/PTFE/TiH2 is almost the same under oxygen atmosphere.	Oxygen	143-149	RuvB like AAA ATPase 2	Homo sapiens	113-117
34380313-2	2021	We recently reported a Co(III)-N2O2 complex with a 2,2"-bipyridine-based ligand backbone which showed alternative selectivity: H2O was observed as the primary reduction product from O2 (71 +- 5%) with decamethylferrocene as a chemical reductant and acetic acid as a proton donor in methanol solution.	Oxygen	182-184	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	23-30
34502897-1	2021	In order to obtain the chemical reaction mechanism of Al-rich Al/PTFE/TiH2 composites in argon and oxygen atmosphere, Al/PTFE, PTFE/TiH2, Al/TiH2 and Al-rich Al/PTFE/TiH2 with different contents of TiH2 composites were prepared by using the wet mixing method.	Oxygen	99-105	RuvB like AAA ATPase 2	Homo sapiens	70-74
34502897-4	2021	The compositions of TG-DSC residues at different peak temperatures and 1000  C and the residues of oxygen bomb experiment were analyzed by X-ray diffraction (XRD), The results show that the pyrolytic products of Al-rich Al/PTFE/TiH2 materials under argon atmosphere can be divided into four stages.	Oxygen	99-105	RuvB like AAA ATPase 2	Homo sapiens	228-232
34245858-5	2021	Numerous genes involved in response to oxygen levels, erythrocyte and myeloid differentiation, macrophage chemotaxis, response to chemicals, apoptosis, RNA destabilization, endosome organization, and vesicle transport were differentially expressed in PMNs cKO for Arf6.	Oxygen	39-45	ADP-ribosylation factor 6	Mus musculus	264-268
34477752-6	2021	After PMP@Alb treatment, remarkably enhanced intra-tumoral drug accumulation, oxygen perfusion and T cell infiltration could be observed owing to the disrupted tumor vessel barriers.	Oxygen	78-84	albumin	Homo sapiens	6-13
34334354-6	2021	In these HeLa cells, overexpression of a wild-type HPDL gene can rescue the respiratory phenotype of oxygen consumption rate.	Oxygen	101-107	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	51-55
34440909-2	2021	EPO production is activated by hypoxia and is regulated via an oxygen-sensitive feedback loop.	Oxygen	63-69	erythropoietin	Homo sapiens	0-3
34137488-1	2021	Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals.	Oxygen	76-82	egl-9 family hypoxia inducible factor 1	Homo sapiens	54-58
34411243-1	2022	Hypoxia-inducible factors (HIF) were discovered as activators of erythropoietin gene transcription in response to reduced O2 availability.	Oxygen	122-124	erythropoietin	Homo sapiens	65-79
34252790-5	2021	Among them, compound 7q bearing oxygen-containing fused rings was shown to significantly stimulate the cellular Nrf2 signaling pathway, including activation of antioxidant response element (ARE)-controlled expression of Nrf2 target genes and proteins.	Oxygen	32-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
34252790-5	2021	Among them, compound 7q bearing oxygen-containing fused rings was shown to significantly stimulate the cellular Nrf2 signaling pathway, including activation of antioxidant response element (ARE)-controlled expression of Nrf2 target genes and proteins.	Oxygen	32-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	220-224
34492937-5	2021	Particularly, new energy levels of oxygen atoms were generated and matched with that of Pb(II).	Oxygen	35-41	submaxillary gland androgen regulated protein 3B	Homo sapiens	88-94
34445307-1	2021	Hypoxic conditions induce the activation of hypoxia-inducible factor-1alpha (HIF-1alpha) to restore the supply of oxygen to tissues and cells.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-75
34445307-1	2021	Hypoxic conditions induce the activation of hypoxia-inducible factor-1alpha (HIF-1alpha) to restore the supply of oxygen to tissues and cells.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
34353274-3	2022	Similar findings are obtained regarding protease inhibitors" effect on cytokine-induced neutrophil activation that suppresses Granulocyte-macrophage colony-stimulating-factor (GM-CSF) TNF-alpha-induced O2 release and adherence in human neutrophils without affecting phosphorylation of Extracellular signal-regulated kinase (ERK) and p38.	Oxygen	202-204	tumor necrosis factor	Homo sapiens	184-193
34393650-7	2021	Alveolar and lung interstitial macrophages from LysM-cre x Hif1alpha fl/fl mice produced lower amounts of the immune enhancing cytokine tumor necrosis factor upon stimulation with Klebsiella, while their capacity to phagocytose or to produce reactive oxygen species was unaltered.	Oxygen	251-257	lysozyme 2	Mus musculus	48-52
34114261-5	2021	Formulation of a hydroxy-substituted gold(I)-dtc complex with excess sulfobutylether-beta-CD prevents the induction of mitochondrial reactive oxygen species, which is a major burden in the development of metallodrugs.	Oxygen	142-148	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	85-92
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Oxygen	13-19	glutathione S-transferase mu 1	Homo sapiens	251-254
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Oxygen	13-19	glutathione S-transferase mu 1	Homo sapiens	261-264
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Oxygen	205-211	glutathione S-transferase mu 1	Homo sapiens	251-254
34355571-3	2021	We found the oxygen evolution reaction is controlled by the formation of empty Ir 5d states in the surface ascribed to the formation of formally IrV species leading to the appearance of electron-deficient oxygen species bound to single iridium atoms (mu1-O and mu1-OH) that are responsible for water activation and oxidation.	Oxygen	205-211	glutathione S-transferase mu 1	Homo sapiens	261-264
34362878-0	2021	E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression.	Oxygen	82-88	epithelial splicing regulatory protein 1	Homo sapiens	99-104
34362878-9	2021	These two oxygen-sensitive epigenetic events work in concert to repel E2F1 from the ESRP1 promoter, thereby diminishing ESRP1 expression under hypoxia.	Oxygen	10-16	epithelial splicing regulatory protein 1	Homo sapiens	84-89
34362878-9	2021	These two oxygen-sensitive epigenetic events work in concert to repel E2F1 from the ESRP1 promoter, thereby diminishing ESRP1 expression under hypoxia.	Oxygen	10-16	epithelial splicing regulatory protein 1	Homo sapiens	120-125
34292705-1	2021	Hemes have been suggested to play a central role in Alzheimer"s disease since they show high peroxidase reactivity when bound to amyloid beta peptides, leading to the production of reactive oxygen species.	Oxygen	190-196	amyloid beta precursor protein	Homo sapiens	129-141
34211090-5	2021	PIM1 kinase directly phosphorylates HIF-1alpha at threonine 455, a previously uncharacterized site within its oxygen-dependent degradation domain.	Oxygen	110-116	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
34098060-8	2021	Moreover, p27 is controlled by the external oxygen and nutrients that are modelled with the reaction-diffusion equations.	Oxygen	44-50	dynactin subunit 6	Homo sapiens	10-13
34349350-0	2021	Long non-coding RNA ZFAS1 exerts a protective role to alleviate oxygen and glucose deprivation-mediated injury in ischemic stroke cell model through targeting miR-186-5p/MCL1 axis.	Oxygen	64-70	zinc finger, NFX1-type containing 1, antisense RNA 1	Mus musculus	20-25
34440146-0	2021	Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions.	Oxygen	11-17	interleukin 10	Mus musculus	186-191
34331407-0	2021	MicroRNA-410 serves as a candidate biomarker in hypoxic-ischemic encephalopathy newborns and provides neuroprotection in oxygen-glucose deprivation-injured PC12 and SH-SY5Y cells.	Oxygen	121-127	microRNA 410	Rattus norvegicus	0-12
34331407-3	2021	This study aims to investigate the expression and diagnostic performance of miR-410 in HIE newborns, and explores the neuroprotective effect of miR-410 in an oxygen-glucose deprivation (OGD)-induced cell injury model.	Oxygen	158-164	microRNA 410	Rattus norvegicus	144-151
34293347-7	2021	NOX2 autoactivation begins when active Rac triggers NOX2 activation and the subsequent production of O2-, which in turn activates redox-sensitive Rac.	Oxygen	101-104	AKT serine/threonine kinase 1	Homo sapiens	39-42
34293347-7	2021	NOX2 autoactivation begins when active Rac triggers NOX2 activation and the subsequent production of O2-, which in turn activates redox-sensitive Rac.	Oxygen	101-104	AKT serine/threonine kinase 1	Homo sapiens	146-149
34211090-5	2021	PIM1 kinase directly phosphorylates HIF-1alpha at threonine 455, a previously uncharacterized site within its oxygen-dependent degradation domain.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
34361818-3	2021	Angiotensin II can contribute to DNA damage through oxidative stress by activating the NAD(P)H oxidase pathway, which in turn results in the production of reactive oxygen species.	Oxygen	164-170	angiotensinogen	Homo sapiens	0-14
34361818-5	2021	Considering the role of angiotensin in aging, melatonin might relieve angiotensin-II-induced stress by enhancing the mitochondrial calcium uptake 1 pathway, which is crucial in preventing the mitochondrial calcium overload that may trigger increased production of reactive oxygen species and oxidative stress.	Oxygen	273-279	angiotensinogen	Homo sapiens	70-84
34362196-8	2021	In a multivariate analysis, the oxygen desaturation index and TNF-alpha genotypes from GG to GA and GA to AA as well as the TNF-alpha-308A allele carriage were significantly associated with the circulating TNF-alpha levels.	Oxygen	32-38	tumor necrosis factor	Homo sapiens	206-215
34439467-4	2021	Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide anion (O2-) in the extracellular environment.	Oxygen	120-123	superoxide dismutase 3	Homo sapiens	0-34
34359734-1	2021	Hypoxia-Inducible Factor 1alpha (HIF-1alpha), which promotes cancer cell survival, is the main regulator of oxygen homeostasis.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
34359734-1	2021	Hypoxia-Inducible Factor 1alpha (HIF-1alpha), which promotes cancer cell survival, is the main regulator of oxygen homeostasis.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
34360999-3	2021	CYP2E1 is a unique P450 enzyme because its heme iron is constitutively in the high spin state, allowing direct reduction of, e.g., dioxygen, causing the formation of a variety of reactive oxygen species and reduction of xenobiotics to toxic products.	Oxygen	131-139	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
34439955-2	2021	A reduction in cellular oxygen levels induces the stabilization of hypoxia inducible factor alpha (HIF-1alpha), master regulator of the molecular response to hypoxia, involved in maintaining cellular homeostasis and driving hypoxic adaptation through the control of gene expression.	Oxygen	24-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
34439467-4	2021	Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide anion (O2-) in the extracellular environment.	Oxygen	120-123	superoxide dismutase 3	Homo sapiens	36-41
34325641-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimer protein composed of an oxygen-regulated functional subunit, HIF-1alpha, and a structural subunit, HIF-1beta, belonging to the basic helix-loop-helix family.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
34325641-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimer protein composed of an oxygen-regulated functional subunit, HIF-1alpha, and a structural subunit, HIF-1beta, belonging to the basic helix-loop-helix family.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
34325641-1	2021	Hypoxia-inducible factor-1 (HIF-1) is a heterodimer protein composed of an oxygen-regulated functional subunit, HIF-1alpha, and a structural subunit, HIF-1beta, belonging to the basic helix-loop-helix family.	Oxygen	75-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
34325641-4	2021	As a master oxygen-sensitive transcription regulator, HIF-1 is responsible for upregulating a broad spectrum of target genes involved in glucose metabolism, angiogenesis, and erythropoiesis to generate the adaptive response to avoid or minimize hypoxic brain injury.	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-59
34360913-9	2021	These data suggest that CSH is necessary to facilitate adequate blood flow for the uptake of oxygen, oxidative substrates, and hormones essential to support fetal and uterine growth.	Oxygen	93-99	chorionic somatomammotropin hormone	Ovis aries	24-27
34325641-5	2021	However, prolonged, severe oxygen deprivation may directly contribute to the role-conversion of HIF-1, namely.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
34318599-8	2022	CONCLUSION: Oxygen saturation, visual acuity and central retinal thickness improve in parallel during treatment of branch retinal vein occlusion with intravitreal anti-VEGF medication.	Oxygen	12-18	vascular endothelial growth factor A	Homo sapiens	168-172
34401326-4	2021	After verifying the conservation of the hypoxia-responsive pathway in CHO cell lines by analyzing oxygen sensing proteins HIF1a, HIF1beta and VDL, hypoxia-response-elements (HREs) were functionally analyzed and used to create hypoxia-responsive expression vectors.	Oxygen	98-104	hypoxia-inducible factor 1-alpha	Cricetulus griseus	122-127
34182229-8	2021	In contrast, significantly lower levels of reactive oxygen metabolites (d-ROMs) activation were identified in IL8-h2 and IL8-het cows after calving compared with IL8-h1 cows.	Oxygen	52-58	C-X-C motif chemokine ligand 8	Bos taurus	110-113
34182229-8	2021	In contrast, significantly lower levels of reactive oxygen metabolites (d-ROMs) activation were identified in IL8-h2 and IL8-het cows after calving compared with IL8-h1 cows.	Oxygen	52-58	C-X-C motif chemokine ligand 8	Bos taurus	121-124
34440325-5	2021	Secondary congenital erythrocytosis can arise through a variety of genetic mechanisms, including mutations in the genes in the oxygen sensing pathway, with high oxygen affinity hemoglobin variants and mutations in other genes such as BPMG, where ultimately the production of erythropoietin is increased, resulting in erythrocytosis.	Oxygen	127-133	erythropoietin	Homo sapiens	275-289
34360780-2	2021	The NO-sGC-cGMP pathway plays an important role in skeletal muscle function, primarily by improving blood flow and oxygen supply to the muscles during exercise.	Oxygen	115-121	sarcoglycan beta	Homo sapiens	7-10
34820583-4	2022	Benefitting from the catalase (CAT)-like activity, the hydrogel could decompose H2O2 into O2 at neutral pH to relieve hypoxia and supply adequate O2.	Oxygen	90-92	catalase	Homo sapiens	31-34
34820583-4	2022	Benefitting from the catalase (CAT)-like activity, the hydrogel could decompose H2O2 into O2 at neutral pH to relieve hypoxia and supply adequate O2.	Oxygen	146-148	catalase	Homo sapiens	31-34
34259248-0	2021	Heme is responsible for enhanced singlet oxygen deactivation in cytochrome c.	Oxygen	41-47	cytochrome c, somatic	Homo sapiens	64-76
34251177-3	2021	Here, an acid oxidation strategy is proposed as an effective strategy to boost the 2e- ORR activity of metallic TiC via in-site generation of a surface amorphous oxygen-deficient TiO2-x layer.	Oxygen	162-168	pleckstrin and Sec7 domain containing 4	Homo sapiens	112-115
34360606-10	2021	AP-1 significantly enhanced the inhibitory effect of DOX against MCF7 cell proliferation in a dose-dependent manner with significant inhibition of the reactive oxygen species (p < 0.0001) compared to DOX alone.	Oxygen	160-166	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
34255515-6	2021	In hypoxia (<0.1% O2), the inhibition of the CREBBP/EP300 bromodomain results in the enhanced stabilization of HIF-1alpha.	Oxygen	18-20	CREB binding protein	Homo sapiens	45-51
34255515-6	2021	In hypoxia (<0.1% O2), the inhibition of the CREBBP/EP300 bromodomain results in the enhanced stabilization of HIF-1alpha.	Oxygen	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
34452092-2	2021	Catalase, an antioxidant enzyme, is a promising therapeutic due to its ability to scavenge toxic reactive oxygen species and improve tissue oxygen status.	Oxygen	140-146	catalase	Rattus norvegicus	0-8
34356382-6	2021	This is attributed mainly to the consumption of ambient oxygen by NO  to form NO2- and/or NO3- but also to the reduction of O2 to superoxide anion (O2 -) by stray electrons from the electron transport chain, leading to the formation of peroxynitrite (ONOO-).	Oxygen	56-62	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
34439408-0	2021	A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells.	Oxygen	71-77	insulin	Homo sapiens	94-101
34356382-6	2021	This is attributed mainly to the consumption of ambient oxygen by NO  to form NO2- and/or NO3- but also to the reduction of O2 to superoxide anion (O2 -) by stray electrons from the electron transport chain, leading to the formation of peroxynitrite (ONOO-).	Oxygen	124-126	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
34336009-4	2021	Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis.	Oxygen	106-112	albumin	Homo sapiens	0-7
34285132-0	2021	Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1alpha/2alpha.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-138
34285132-4	2021	Here, we used immunoprecipitation-based mass spectrometry to characterize the PTMs and binding partners for full-length HIF-1alpha and HIF-2alpha under normoxic (21% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	166-172	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
34285132-4	2021	Here, we used immunoprecipitation-based mass spectrometry to characterize the PTMs and binding partners for full-length HIF-1alpha and HIF-2alpha under normoxic (21% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	190-196	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
34276052-3	2021	When two ESCC cell lines (TE1, KYSE410) were exposed to hypoxia (0.1% O2), CLDN1/4 was shown to influence the occurrence and development of esophageal cancer.	Oxygen	70-72	claudin 14	Homo sapiens	75-82
34349617-7	2021	By increasing production of reactive oxygen species, insulin resistance triggers amyloid beta-protein accumulation.	Oxygen	37-43	insulin	Homo sapiens	53-60
34279223-6	2021	These results demonstrated that KSHV utilizes a unique strategy to balance HIF1alpha levels to overcome replication arrest and induction of the oncogenic phenotype, which are dependent on the levels of oxygen in the microenvironment.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-84
34266485-1	2021	BACKGROUND: Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide.	Oxygen	168-174	superoxide dismutase 1	Homo sapiens	34-37
34336855-15	2021	The combination of gut-derived LPS and LSEC-derived TNF-alpha led to the activation of neutrophils, characterized by enhanced production of reactive oxygen species, pro-inflammatory cytokines, and the formation of neutrophil extracellular traps.	Oxygen	149-155	tumor necrosis factor	Rattus norvegicus	52-61
34264930-4	2021	We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra.	Oxygen	14-20	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	61-66
34386732-0	2021	Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.	Oxygen	39-45	src family associated phosphoprotein 2	Mus musculus	20-25
34299186-6	2021	Therefore, this study aimed to unravel the effect of hypoxia (2% O2) on the expression of RNASET2 in DCs.	Oxygen	65-67	ribonuclease T2	Homo sapiens	90-97
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	13-19	catalase	Homo sapiens	64-72
34197086-7	2021	In response to intracellular glutathione, Pt(II) is released from CPNP-Fc/Pt and triggers enzymatic cascade reactions with nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) and superoxide dismutase to convert oxygen into H2O2.	Oxygen	227-233	dual oxidase 2	Homo sapiens	123-174
34259984-10	2022	Inhibition of xCT exacerbated cardiomyocyte hypertrophy and boosted the levels of ferroptosis biomarkers Ptgs2, malondialdehyde, and reactive oxygen species induced by Ang II, while overexpression of xCT opposed these detrimental effects.	Oxygen	142-148	angiotensinogen	Rattus norvegicus	168-174
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	13-19	catalase	Homo sapiens	74-77
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	145-151	catalase	Homo sapiens	64-72
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	145-151	catalase	Homo sapiens	74-77
34242227-8	2021	We present evidence that the crosstalk between HIF-1 and SKN-1 is mediated by EGL-9, the prolyl hydroxylase that targets HIF-1 for oxygen-dependent degradation.	Oxygen	131-137	Hypoxia-inducible factor 1	Caenorhabditis elegans	47-52
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	153-155	catalase	Homo sapiens	64-72
34242227-8	2021	We present evidence that the crosstalk between HIF-1 and SKN-1 is mediated by EGL-9, the prolyl hydroxylase that targets HIF-1 for oxygen-dependent degradation.	Oxygen	131-137	Hypoxia-inducible factor 1	Caenorhabditis elegans	121-126
34356639-4	2021	Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.	Oxygen	153-155	catalase	Homo sapiens	74-77
34267521-0	2021	Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through Regulation of the TLR4/MyD88/NF-kappaB Pathway.	Oxygen	66-72	toll-like receptor 4	Mus musculus	187-191
34267521-0	2021	Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through Regulation of the TLR4/MyD88/NF-kappaB Pathway.	Oxygen	66-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	198-207
34247775-1	2021	Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment, participates in many physiological and pathological processes in the body, and is closely related to the pathogenesis of many diseases.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
34228878-3	2021	Hypoxia, i.e. the scarcity of oxygen, is a hallmark of solid tumors to which they adapt by activating hypoxia-inducible factor-1 (HIF-1), a transcription factor triggering de novo angiogenesis.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-128
34228878-3	2021	Hypoxia, i.e. the scarcity of oxygen, is a hallmark of solid tumors to which they adapt by activating hypoxia-inducible factor-1 (HIF-1), a transcription factor triggering de novo angiogenesis.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-135
34128654-2	2021	Studies of the magnetic properties of NiII3O(Hhp) and CuII3O(Hhp) reveal a diamagnetic and EPR-silent trianionic (Hhp3-) macrocycle and diamagnetic NiII3(O2-) or paramagnetic CuII3(O2-) tetracations.	Oxygen	181-184	IH	Homo sapiens	61-64
34210376-3	2022	The ratio of central venous to arterial carbon dioxide tension to arterio-venous oxygen content (PV-ACO2/CA-VO2) has been proposed as a surrogate for respiratory quotient and an indicator of tissue oxygenation.	Oxygen	81-87	aconitase 2	Homo sapiens	100-104
34128654-2	2021	Studies of the magnetic properties of NiII3O(Hhp) and CuII3O(Hhp) reveal a diamagnetic and EPR-silent trianionic (Hhp3-) macrocycle and diamagnetic NiII3(O2-) or paramagnetic CuII3(O2-) tetracations.	Oxygen	154-157	IH	Homo sapiens	45-48
34128654-2	2021	Studies of the magnetic properties of NiII3O(Hhp) and CuII3O(Hhp) reveal a diamagnetic and EPR-silent trianionic (Hhp3-) macrocycle and diamagnetic NiII3(O2-) or paramagnetic CuII3(O2-) tetracations.	Oxygen	154-157	IH	Homo sapiens	61-64
34128654-2	2021	Studies of the magnetic properties of NiII3O(Hhp) and CuII3O(Hhp) reveal a diamagnetic and EPR-silent trianionic (Hhp3-) macrocycle and diamagnetic NiII3(O2-) or paramagnetic CuII3(O2-) tetracations.	Oxygen	181-184	IH	Homo sapiens	45-48
34558450-1	2021	Context: Obstructive sleep apnea (OSA)-related hypoxemia stimulates release of acute-phase proteins and reactive oxygen species that exacerbate insulin resistance and lipolysis and cause an augmented prothrombotic and proinflammatory state which can leads to premature death.	Oxygen	113-119	insulin	Homo sapiens	144-151
34247775-1	2021	Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment, participates in many physiological and pathological processes in the body, and is closely related to the pathogenesis of many diseases.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
34118098-8	2021	We identified that mid-symptomatic SOD1G93A mice have increased oxygen consumption and faster exogenous glucose uptake, despite presenting with normal insulin tolerance.	Oxygen	64-70	superoxide dismutase 1, soluble	Mus musculus	35-39
34209205-1	2021	Erythropoiesis is regulated by several factors, including the oxygen-sensing pathway as the main regulator of erythropoietin (EPO) synthesis in the kidney.	Oxygen	62-68	erythropoietin	Homo sapiens	110-124
34182480-9	2021	Furthermore, tetrandrine significantly increased expression of reactive oxygen species-associated proteins such as superoxide dismutase (Cu/Zn) and superoxide dismutase (Mn) but significantly reduced the level of catalase, which was also confirmed by confocal laser microscopy.	Oxygen	72-78	superoxide dismutase 1	Homo sapiens	115-142
34118566-1	2021	Superoxide Dismutase 1 (SOD1) is an antioxidant enzyme that protects the cells from radical oxygen species.	Oxygen	92-98	superoxide dismutase 1	Homo sapiens	0-22
34118566-1	2021	Superoxide Dismutase 1 (SOD1) is an antioxidant enzyme that protects the cells from radical oxygen species.	Oxygen	92-98	superoxide dismutase 1	Homo sapiens	24-28
34133955-2	2021	Hypoxia-inducible factors (HIFs), including HIF-1 and HIF-2, are transcription factors that respond to reduced intracellular O2 availability.	Oxygen	125-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-49
34083809-2	2021	During homeostatic development, oxygen-dependent prolyl hydroxylases, circadian clock proteins and metabolic intermediates control the activities of HIF1 and HIF2 in these tissues.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-153
34108686-5	2021	Conditional deletion of TIM-3 in DCs led to increased accumulation of reactive oxygen species resulting in NLRP3 inflammasome activation.	Oxygen	79-85	NLR family pyrin domain containing 3	Homo sapiens	107-112
34106680-6	2021	The CsPb1-xErxBr3-ZBLAN fluoride glass can prevent the perovskite from being destroyed by water, oxygen, and laser.	Oxygen	97-103	mitogen-activated protein kinase 14	Homo sapiens	4-9
34234608-10	2021	An increase in the expression of the CD34 antigen and other hematopoietic antigens were observed to 1% O2 with MSCs plus ECs and low ROS levels.	Oxygen	103-105	CD34 molecule	Homo sapiens	37-41
34209205-1	2021	Erythropoiesis is regulated by several factors, including the oxygen-sensing pathway as the main regulator of erythropoietin (EPO) synthesis in the kidney.	Oxygen	62-68	erythropoietin	Homo sapiens	126-129
34182839-9	2022	Only 2 additional patients demonstrated a worsening in O2 nadir on PON 1, each by only 1 percentage point.	Oxygen	55-57	paraoxonase 1	Homo sapiens	67-72
34262470-8	2021	Lastly, we identified an association between the ACE gene insertion/deletion (I/D) polymorphism and oxygen saturation, as well as average ACE methylation.	Oxygen	100-106	angiotensin I converting enzyme	Homo sapiens	49-52
34180675-8	2021	The results showed that the produced O2 significantly alleviated the hypoxia of TME to down-regulate the expression of HIF-1alpha, and the produced ROS can efficiently kill tumor cells.	Oxygen	37-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
34262860-7	2021	This differential therapeutic response was correlated with the regulation of CYP3A4 expression levels under the influence of stiffness and oxygen variation.	Oxygen	139-145	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
34900840-10	2021	It can be said that diabetes with the action of reactive oxygen species through oxidative stress, increases ICAM-1 and TNF-alpha and decreases heparanase enzyme, it affects the glomerular endothelium and eventually leads to albuminuria and destruction of the Glx layer.	Oxygen	57-63	tumor necrosis factor	Homo sapiens	119-128
34248676-10	2021	Group C (7% O2) had higher levels of IL-6, IL-10, and TNF-alpha.	Oxygen	12-14	interleukin 6	Rattus norvegicus	37-41
34248676-10	2021	Group C (7% O2) had higher levels of IL-6, IL-10, and TNF-alpha.	Oxygen	12-14	tumor necrosis factor	Rattus norvegicus	54-63
34142808-6	2021	Moreover, catalase-mimicking CFP could react with endogenous H2O2 to generate molecular oxygen, and high O2 level may promote the production of 1O2 for SDT.	Oxygen	88-94	complement factor properdin	Homo sapiens	29-32
34161263-9	2021	Furthermore, U-13C6-glucose labeling of MCT1/4-inhibited LCLs revealed depleted glutathione pools that correlated with elevated reactive oxygen species.	Oxygen	137-143	solute carrier family 16 member 1	Homo sapiens	40-44
34154631-0	2021	The ROX index as a predictor of standard oxygen therapy outcomes in thoracic trauma.	Oxygen	41-47	MAX network transcriptional repressor	Homo sapiens	4-7
34154631-3	2021	The main objective of this study was to assess the accuracy of the ROX index in predicting successful standard oxygen (SO) therapy outcomes, and in pre-empting intubation.	Oxygen	111-117	MAX network transcriptional repressor	Homo sapiens	67-70
34154631-9	2021	CONCLUSION: We have shown that a ROX index greater than 12.85 at 24 h was linked to successful standard oxygen therapy outcomes in critical thoracic trauma patients.	Oxygen	104-110	MAX network transcriptional repressor	Homo sapiens	33-36
34158477-5	2021	Likewise, Alb activation of hHv1 in neutrophils is required to sustain production and release of reactive oxygen species during the immune respiratory burst.	Oxygen	106-112	albumin	Homo sapiens	10-13
34158545-1	2021	The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk of requiring oxygen support based on five parameters: C-reactive protein (CRP), hypertension, age, and neutrophil and lymphocyte counts (CHANeL).	Oxygen	129-135	C-reactive protein	Homo sapiens	170-188
34158545-1	2021	The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk of requiring oxygen support based on five parameters: C-reactive protein (CRP), hypertension, age, and neutrophil and lymphocyte counts (CHANeL).	Oxygen	129-135	C-reactive protein	Homo sapiens	190-193
34158545-8	2021	"CHANeL" prediction models based on serial CRP, neutrophil, and lymphocyte counts during the first 3 days of hospitalization, along with age and hypertension status, provide a reliable estimate of the risk of supplement oxygen requirement among patients hospitalized with COVID-19.	Oxygen	220-226	C-reactive protein	Homo sapiens	43-46
34142808-6	2021	Moreover, catalase-mimicking CFP could react with endogenous H2O2 to generate molecular oxygen, and high O2 level may promote the production of 1O2 for SDT.	Oxygen	105-107	complement factor properdin	Homo sapiens	29-32
34204592-9	2021	Treatment with TAT-NDUFS8 not only significantly improved the assembly of complex I in an NDUFS8-deficient cell line, but also partially rescued complex I functions both in the in-gel activity assay and the oxygen consumption assay.	Oxygen	207-213	NADH:ubiquinone oxidoreductase core subunit S8	Homo sapiens	19-25
34076027-4	2021	The ET-1 was wrapped within the network of crosslinked GelMA hydrogels via intermolecular hydrogen bonding interactions, effectively avoiding oxidization by atmospheric oxygen and in vivo enzymatic biodegradation.	Oxygen	169-175	endothelin 1	Homo sapiens	4-8
34220496-5	2021	Convincing data indicate that angiotensin II accelerates hypertension and augments the production of reactive oxygen species.	Oxygen	110-116	angiotensinogen	Homo sapiens	30-44
34306441-0	2021	Huperzine A combined with hyperbaric oxygen on the effect on cognitive function and serum hypoxia-inducible factor-1alpha Level in elderly patients with vascular dementia.	Oxygen	37-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-121
34075953-5	2021	Herein, we designed a nanoprobe based on gold nanoparticles (Au NPs) to monitor the effect of different oxygen and nutrient conditions on the migration and invasion of breast cancer cells through detecting the changes in levels of RAB-22a and MMP-2 mRNA in living cells.	Oxygen	104-110	RAB22A, member RAS oncogene family	Homo sapiens	231-238
33244727-0	2021	Correction to: The inflammation and reactive oxygen species regulated by Nrf2 and NF-kappaB signaling pathways in 630-nm light-emitting diode irradiation treated THP-1 monocytes/macrophages.	Oxygen	45-51	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
34188484-8	2021	TR showed to be effective in the improvement of HF patients" functional capacity in the 6 Minute Walk-Test (Mean Difference (MD) 15.86; CI 95% (7.23; 24.49); I2 = 74%) and in peak oxygen uptake (pVO2) results (MD 1.85; CI 95% (0.16; 3.53); I2 = 93%).	Oxygen	180-186	coagulation factor II thrombin receptor	Homo sapiens	0-2
34111968-8	2021	It is also shown that transferring the insulin solution out of and then back into the insulin pen caused significant change in R2(1H2O), presumably due to exposure to O2 in air.	Oxygen	167-169	insulin	Homo sapiens	39-46
34111968-8	2021	It is also shown that transferring the insulin solution out of and then back into the insulin pen caused significant change in R2(1H2O), presumably due to exposure to O2 in air.	Oxygen	167-169	insulin	Homo sapiens	86-93
34178992-7	2021	In parallel, or resulting from reactive oxygen species, there was greater inflammation in APOE4 brain endothelial cells including higher chemokine levels and immune cell adhesion under basal conditions and after low-dose lipopolysaccharide (LPS) treatment.	Oxygen	40-46	apolipoprotein E	Homo sapiens	90-95
34195614-4	2021	The generated H2O2 could subsequently be decomposed by catalase (CAT) to generate oxygen, which acts as reactants for the abundant singlet oxygen (1O2) production by loaded sonosensitizer hematoporphyrin monomethyl ether (HMME) upon the US irradiation, performing largely elevated therapeutic outcomes of SDT.	Oxygen	82-88	catalase	Homo sapiens	55-63
34195614-4	2021	The generated H2O2 could subsequently be decomposed by catalase (CAT) to generate oxygen, which acts as reactants for the abundant singlet oxygen (1O2) production by loaded sonosensitizer hematoporphyrin monomethyl ether (HMME) upon the US irradiation, performing largely elevated therapeutic outcomes of SDT.	Oxygen	82-88	catalase	Homo sapiens	65-68
34543566-1	2021	OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2).	Oxygen	242-248	interleukin 6	Homo sapiens	50-63
34543566-1	2021	OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2).	Oxygen	242-248	interleukin 6	Homo sapiens	65-69
34543566-1	2021	OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2).	Oxygen	242-248	C-reactive protein	Homo sapiens	75-93
34543566-1	2021	OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2).	Oxygen	242-248	C-reactive protein	Homo sapiens	95-98
34149615-4	2021	Methods: The metabolism of CD4+ T cells from 30 HT patients and 30 healthy controls was evaluated by determining the extracellular acidification rate (ECAR) and the oxygen consumption rate (OCR).	Oxygen	165-171	CD4 molecule	Homo sapiens	27-30
34167616-5	2021	Our experimental results showed that the PLGAgrafted gamma-Fe2O3 nanoparticles could simulate the activity of catalase and decompose hydrogen peroxide into H2O and oxygen in neutral tumor microenvironment, thus reducing the oxidative damage caused by hydrogenperoxide to lung adenocarcinoma A549 cells.	Oxygen	164-170	catalase	Homo sapiens	110-118
33269748-7	2021	Our results showed that TIGAR expression was increased in the neonatal rat cortex after HIBD and in HAPI microglial cells after oxygen/glucose deprivation/reoxygenation.	Oxygen	128-134	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	24-29
33244727-0	2021	Correction to: The inflammation and reactive oxygen species regulated by Nrf2 and NF-kappaB signaling pathways in 630-nm light-emitting diode irradiation treated THP-1 monocytes/macrophages.	Oxygen	45-51	GLI family zinc finger 2	Homo sapiens	162-167
34073032-0	2021	Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts.	Oxygen	109-115	C-X-C motif chemokine ligand 9	Homo sapiens	50-56
34075096-0	2021	The blood oxygen level dependent (BOLD) effect of in-vitro myoglobin and hemoglobin.	Oxygen	10-16	myoglobin	Equus caballus	59-68
34124069-0	2021	Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy.	Oxygen	196-202	protein tyrosine phosphatase, non-receptor type 9	Rattus norvegicus	0-48
34072492-2	2021	The ion-enhanced etch characteristics of sp2-rich a-C:H films on ion density and ion energy were investigated in CF4 plasmas and O2 plasmas in this work.	Oxygen	129-131	Sp2 transcription factor	Homo sapiens	41-44
34072492-3	2021	The etch rate of sp2-rich a-C:H films in O2 plasmas increased linearly with ion density when no bias power was applied, while the fluorocarbon deposition was observed in CF4 plasmas instead of etching without bias power.	Oxygen	41-43	Sp2 transcription factor	Homo sapiens	17-20
34124069-0	2021	Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy.	Oxygen	196-202	protein tyrosine phosphatase, non-receptor type 9	Rattus norvegicus	50-55
34093011-0	2021	Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen-Glucose Deprivation-Induced Ischemic Neuronal Injury.	Oxygen	87-93	fatty acid amide hydrolase	Homo sapiens	57-61
34079264-1	2021	Background: The aim of our study was to explore the role of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in ischemic stroke using oxygen-glucose deprivation/reperfusion (OGD/R)-induced bEnd.3 cells as in vitro cell model.	Oxygen	146-152	growth arrest specific 5	Mus musculus	89-113
34079264-1	2021	Background: The aim of our study was to explore the role of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in ischemic stroke using oxygen-glucose deprivation/reperfusion (OGD/R)-induced bEnd.3 cells as in vitro cell model.	Oxygen	146-152	growth arrest specific 5	Mus musculus	115-119
34069422-4	2021	Overproduction of reactive oxygen species can promote an imbalance between the production and neutralization of antioxidant defence systems, thus favoring lipid accumulation, cellular stress, and the activation of cytosolic signaling pathways, and inducing beta-cell dysfunction, insulin resistance, and tissue inflammation.	Oxygen	27-33	insulin	Homo sapiens	280-287
34367665-5	2021	We find the strongest signal for adaptation at EGLN1, a classic target for convergent evolution in several species living in low oxygen environments.	Oxygen	129-135	egl-9 family hypoxia inducible factor 1	Macaca mulatta	47-52
34194697-6	2021	Here for the first time, we demonstrate that densely-arrayed Cu nanopyramids (Cu-DAN) are able to retain two oxygen atoms for hydroxyl formation.	Oxygen	109-115	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
34067535-4	2021	Our study reveals that O2 and NO  use the same entry pores and channels connecting to 15LOX-2 catalytic site, resulting in a competition for the catalytic site.	Oxygen	23-25	arachidonate 15-lipoxygenase	Homo sapiens	86-91
34068590-2	2021	In hypoxia, mammals respond by modulating O2-sensitive transducers that stabilize the transcription factor hypoxia-inducible factor-1-alpha (HIF-1alpha), which transactivates the genes that govern angiogenesis and metabolic pathways.	Oxygen	42-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-139
34068590-2	2021	In hypoxia, mammals respond by modulating O2-sensitive transducers that stabilize the transcription factor hypoxia-inducible factor-1-alpha (HIF-1alpha), which transactivates the genes that govern angiogenesis and metabolic pathways.	Oxygen	42-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
34068590-9	2021	With oxygen treatment, the HIF-1alpha and EPO decreased in COPD and OSA but not in fibrosis, and VEGF remained constant over time.	Oxygen	5-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
34068590-9	2021	With oxygen treatment, the HIF-1alpha and EPO decreased in COPD and OSA but not in fibrosis, and VEGF remained constant over time.	Oxygen	5-11	erythropoietin	Homo sapiens	42-45
34068590-11	2021	In pulmonary fibrosis, HIF-1alpha, EPO, and VEGF increased with oxygen therapy, which is likely linked to the disease"s pathogenesis and clinical course rather than hypoxemia.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
34068590-11	2021	In pulmonary fibrosis, HIF-1alpha, EPO, and VEGF increased with oxygen therapy, which is likely linked to the disease"s pathogenesis and clinical course rather than hypoxemia.	Oxygen	64-70	erythropoietin	Homo sapiens	35-38
34068590-11	2021	In pulmonary fibrosis, HIF-1alpha, EPO, and VEGF increased with oxygen therapy, which is likely linked to the disease"s pathogenesis and clinical course rather than hypoxemia.	Oxygen	64-70	vascular endothelial growth factor A	Homo sapiens	44-48
34334796-1	2021	We report the detection of the oxygen-bearing complex organic molecules propenal (C2H3CHO), vinyl alcohol (C2H3OH), methyl formate (HCOOCH3), and dimethyl ether (CH3OCH3) toward the cyanopolyyne peak of the starless core TMC-1.	Oxygen	31-37	transmembrane channel like 1	Homo sapiens	221-226
34064734-2	2021	In this work, a cost-effective synthesis strategy for nitrogen and oxygen co-doped porous carbon (NOC) from petroleum sludge waste was developed.	Oxygen	67-73	nocturnin	Homo sapiens	98-101
34137233-3	2021	In Alzheimer"s disease, TRPM2 is activated by reactive oxygen species generated by beta-amyloid peptide to form a malignant positive feedback loop that induces neuronal death and is involved in the pathological process of glial cells by promoting inflammatory response and oxidative stress.	Oxygen	55-61	amyloid beta precursor protein	Homo sapiens	83-103
34063627-7	2021	In this review, we aim to summarize the present knowledge of JNK-mediated processes in TME, including hypoxia, reactive oxygen species, inflammation, immune responses, angiogenesis, as well as the regulation of various cell populations within TME.	Oxygen	120-126	mitogen-activated protein kinase 8	Homo sapiens	61-64
34064531-7	2021	Oxygen consumption in mitochondria was maximized in salt-treated and MEK6 transfected WAT, but it was decreased by 50% in BLA.	Oxygen	0-6	mitogen-activated protein kinase kinase 6	Homo sapiens	69-73
34430053-1	2021	Purpose: To investigate whether patients with normal tension glaucoma (NTG) show an enhanced stress response to reduced oxygen supply compared to age-matched healthy controls, measured by serum adrenaline and endothelin-1 (ET-1) levels and changes in distal finger temperature.	Oxygen	120-126	endothelin 1	Homo sapiens	209-221
34430053-1	2021	Purpose: To investigate whether patients with normal tension glaucoma (NTG) show an enhanced stress response to reduced oxygen supply compared to age-matched healthy controls, measured by serum adrenaline and endothelin-1 (ET-1) levels and changes in distal finger temperature.	Oxygen	120-126	endothelin 1	Homo sapiens	223-227
34927821-3	2021	The nano-riceball (NGR@DDP) possesses a well-designed core-shell structure, formed by an inner core assembly that contains ultrasound/H2 O2 responsive bottlebrush-like unimolecular dextran-POEGMA9 -b-PMTEMA22 (DOS) with co-loaded doxorubicin and Purpurin 18.	Oxygen	137-139	reticulon 4 receptor	Mus musculus	19-22
34163712-3	2021	An important example of a pigment-protein complex is CP47, one of the integral antennae of the oxygen-evolving photosystem II (PSII) that is responsible for efficient excitation energy transfer to the PSII reaction center.	Oxygen	95-101	beaded filament structural protein 2	Homo sapiens	53-57
34163743-5	2021	Additionally, to circumvent the undesirable immune response during the process of the bioorthogonal chemistry reaction and Abeta-microglial interaction, Mn-porphyrin metal-organic frameworks (Mn-MOFs) with superoxide dismutase (SOD) and catalase (CAT) mimic activity are employed to carry N-azidoacetylmannosamine (AcManNAz) and eradicate over-expressed reactive oxygen species (ROSs).	Oxygen	363-369	amyloid beta precursor protein	Homo sapiens	123-128
34163706-4	2021	The reaction of 2 with a triphenylcarbon radical further gives triphenylmethanol and mimics the so-called oxygen rebound step of Cpd II of cytochrome P450.	Oxygen	106-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-154
34336022-1	2021	Introduction: Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress.	Oxygen	118-124	catalase	Homo sapiens	14-22
34279211-4	2021	This review describes the known effects of miRNAs on reactive oxygen species to induce oxidative stress and the miRNA regulatory mechanisms involved in the uncoupling of Keap1-Nrf2 complexes.	Oxygen	62-68	NFE2 like bZIP transcription factor 2	Homo sapiens	176-180
34497234-5	2021	Erythropoietin is one of the main targets of HIFs that enhances oxygen delivery by increasing the production of red blood cells.	Oxygen	64-70	erythropoietin	Homo sapiens	0-14
34459765-10	2021	The positive effect of highly concentrated oxygen for local immunity state - the level of secretory immunoglobulin A (p<0.001) and lysozyme (p<0.001) was established.	Oxygen	43-49	lysozyme	Homo sapiens	131-139
34336022-1	2021	Introduction: Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress.	Oxygen	118-124	catalase	Homo sapiens	24-27
35597499-11	2022	The direct target ABL1 is located upstream of Nrf2 and mTOR, Nrf2 can influence the expression of mTOR by affecting the level of reactive oxygen species.	Oxygen	138-144	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
35635894-1	2022	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor which plays a critical role in several biochemical pathways, and consists of oxygen-dependent alpha (alpha) and a constitutively expressed beta (beta) subunit.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
35635894-1	2022	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor which plays a critical role in several biochemical pathways, and consists of oxygen-dependent alpha (alpha) and a constitutively expressed beta (beta) subunit.	Oxygen	138-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
35413630-2	2022	To address its point-of-care testing (POCT), we adapted the O2-dependent aptamer assay for thrombin to gold screen-printed electrodes (Au SPE).	Oxygen	60-62	coagulation factor II, thrombin	Homo sapiens	91-99
35413630-4	2022	Au SPEs modified with thiolated hemin-conjugated aptamer and PEG showed enhanced electrocatalytic activity in O2 reduction upon thrombin binding to the aptamer, then folding into the electroactive hemin-G4 DNAzyme structure.	Oxygen	110-112	coagulation factor II, thrombin	Homo sapiens	128-136
35450661-5	2022	Moreover, catalase was integrated in the hydrogel enabling to convert hydrogen peroxide in TME into dissolved oxygen and alleviate tumor hypoxia.	Oxygen	110-116	catalase	Homo sapiens	10-18
35569548-5	2022	We demonstrated that PDE4B knocking-down increased the expression of TJ and AJ proteins in human brain microvascular endothelial cells (HBMECs) subjected to oxygen-glucose deprivation reperfusion (OGD/R).	Oxygen	157-163	phosphodiesterase 4B	Homo sapiens	21-26
35334317-1	2022	Mechanism of soy protein isolate (SPI) adsorbing isomers of volatile flavor compounds (VFCs: 2-octanone, 1-octen-3-ol and octanal) were investigated by exploring the interaction between different oxygen-containing functional groups (OCF groups: carbonyl, alcohol hydroxyl and aldehyde group) and SPI in this study.	Oxygen	196-202	chromogranin A	Homo sapiens	34-37
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	Oxygen	208-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35500463-3	2022	beta-CD/RGO not only served as the pH sensitive material for pH response electrode with good sensitivity, selectivity and reproducibility due to its abundant oxygen-containing functional groups, but also worked as the ion-to-electron transducer for K+ selective electrode with good sensitivity.	Oxygen	158-164	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-11
35597499-11	2022	The direct target ABL1 is located upstream of Nrf2 and mTOR, Nrf2 can influence the expression of mTOR by affecting the level of reactive oxygen species.	Oxygen	138-144	mechanistic target of rapamycin kinase	Homo sapiens	55-59
35597499-11	2022	The direct target ABL1 is located upstream of Nrf2 and mTOR, Nrf2 can influence the expression of mTOR by affecting the level of reactive oxygen species.	Oxygen	138-144	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
35597499-11	2022	The direct target ABL1 is located upstream of Nrf2 and mTOR, Nrf2 can influence the expression of mTOR by affecting the level of reactive oxygen species.	Oxygen	138-144	mechanistic target of rapamycin kinase	Homo sapiens	98-102
35279910-0	2022	2-mercaptobenzothiazole generates gamma-H2AX via CYP2E1-dependent production of reactive oxygen species in urothelial cells.	Oxygen	89-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	49-55
35575825-6	2022	In particular, it is found that CAT can decompose the endogenous hydrogen peroxide released from the bacteria, and generate oxygen bubbles to carry off the bacteria adhered to the surface.	Oxygen	124-130	catalase	Homo sapiens	32-35
35359221-6	2022	The results from cultured cardiomyocytes also proved that sRAGE attenuated myocardial apoptosis and autophagy through interacting with integrinbeta3 to activate Akt and STAT3 pathway during oxygen and glucose deprivation/reperfusion (OGD/R) treatment.	Oxygen	190-196	thymoma viral proto-oncogene 1	Mus musculus	161-164
35359221-6	2022	The results from cultured cardiomyocytes also proved that sRAGE attenuated myocardial apoptosis and autophagy through interacting with integrinbeta3 to activate Akt and STAT3 pathway during oxygen and glucose deprivation/reperfusion (OGD/R) treatment.	Oxygen	190-196	signal transducer and activator of transcription 3	Mus musculus	169-174
35543151-2	2022	Furthermore, solid tumors often contain hypoxic areas and can rapidly adapt to low oxygen conditions by activating hypoxia inducible factor (HIF)-1alpha and several downstream pathways, thus sustaining cell survival and metabolic reprogramming.	Oxygen	83-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-152
35339753-5	2022	In contrast, interleukin-4 (IL4) and interleukin-13 (IL13) anti-inflammatory stimuli increased the oxygen consumption rates in baseline conditions (21%) and associated with ATP production (19%).	Oxygen	99-105	interleukin 4	Homo sapiens	13-26
35426866-1	2022	BACKGROUND: This retrospective case series compares the outcomes and postoperative oxygen levels in patients who underwent free flap versus primary closure/local flap reconstruction for ischemic diabetic foot wounds to determine the influence of free flap on the surrounding ischemic tissues.	Oxygen	83-89	arachidonate 5-lipoxygenase activating protein	Homo sapiens	128-132
35426866-2	2022	The authors hypothesized that the free flap would benefit the surrounding ischemic tissue as a nutrient flap by increasing the tissue oxygen content.	Oxygen	134-140	arachidonate 5-lipoxygenase activating protein	Homo sapiens	39-43
35426866-2	2022	The authors hypothesized that the free flap would benefit the surrounding ischemic tissue as a nutrient flap by increasing the tissue oxygen content.	Oxygen	134-140	arachidonate 5-lipoxygenase activating protein	Homo sapiens	104-108
35426866-10	2022	CONCLUSION: This study shows that the role of the free flap in ischemic diabetic limb may expand beyond that of providing coverage over the vital structures, and it supports the use of the free flap as a nutrient to increase oxygen content in the ischemic diabetic foot.	Oxygen	225-231	arachidonate 5-lipoxygenase activating protein	Homo sapiens	55-59
35426866-10	2022	CONCLUSION: This study shows that the role of the free flap in ischemic diabetic limb may expand beyond that of providing coverage over the vital structures, and it supports the use of the free flap as a nutrient to increase oxygen content in the ischemic diabetic foot.	Oxygen	225-231	arachidonate 5-lipoxygenase activating protein	Homo sapiens	194-198
35321825-0	2022	Exosomes from M2-polarized macrophages relieve oxygen/glucose deprivation/normalization-induced neuronal injury by activating the Nrf2/HO-1 signaling.	Oxygen	47-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
35321825-0	2022	Exosomes from M2-polarized macrophages relieve oxygen/glucose deprivation/normalization-induced neuronal injury by activating the Nrf2/HO-1 signaling.	Oxygen	47-53	heme oxygenase 1	Mus musculus	135-139
35588203-6	2022	The main ultraviolet/visible excitations along protonation are still associated with an electronic charge transfer phenomenon occurring predominantly from bridging oxygens (Ob) to niobium (Nb) atoms such as those noticed before in the non-protonated structure.	Oxygen	164-171	cadherin 11	Homo sapiens	173-175
35339753-5	2022	In contrast, interleukin-4 (IL4) and interleukin-13 (IL13) anti-inflammatory stimuli increased the oxygen consumption rates in baseline conditions (21%) and associated with ATP production (19%).	Oxygen	99-105	interleukin 4	Homo sapiens	28-31
35437012-1	2022	Activated hypoxia-inducible factor-1alpha (HIF-1alpha) plays an important role in the adaptive response of tumor cells to oxygen changes through the transcriptional activation of genes that regulate important biological processes required for tumor survival and progression.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-41
35437012-1	2022	Activated hypoxia-inducible factor-1alpha (HIF-1alpha) plays an important role in the adaptive response of tumor cells to oxygen changes through the transcriptional activation of genes that regulate important biological processes required for tumor survival and progression.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
35339753-5	2022	In contrast, interleukin-4 (IL4) and interleukin-13 (IL13) anti-inflammatory stimuli increased the oxygen consumption rates in baseline conditions (21%) and associated with ATP production (19%).	Oxygen	99-105	interleukin 13	Homo sapiens	37-51
35339753-5	2022	In contrast, interleukin-4 (IL4) and interleukin-13 (IL13) anti-inflammatory stimuli increased the oxygen consumption rates in baseline conditions (21%) and associated with ATP production (19%).	Oxygen	99-105	interleukin 13	Homo sapiens	53-57
35624485-0	2022	Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1alpha axis to alleviate autoimmune uveitis.	Oxygen	72-78	thioredoxin interacting protein	Mus musculus	87-92
35624495-10	2022	Furthermore, TNF-alpha and IL-1beta increased in CIRI-derived exosomes could increase RIP3 phosphorylation in normal or oxygen-glucose deprivation/reoxygenation (OGD/R) conditions (P < 0.05).	Oxygen	120-126	tumor necrosis factor	Mus musculus	13-22
35624495-10	2022	Furthermore, TNF-alpha and IL-1beta increased in CIRI-derived exosomes could increase RIP3 phosphorylation in normal or oxygen-glucose deprivation/reoxygenation (OGD/R) conditions (P < 0.05).	Oxygen	120-126	myosin phosphatase Rho interacting protein	Mus musculus	86-90
35619548-5	2022	Hdac6 transgenic mice exhibit similar ROP-related defects in retinal structures and functions and disassembly of photoreceptor cilia, whereas Hdac6 knockout mice are resistant to oxygen change-induced retinal defects.	Oxygen	179-185	histone deacetylase 6	Mus musculus	142-147
35612774-12	2022	Comorbid ADNC and mVBI appear to synergistically interact to selectively impair bradykinin-induced vasodilation in WM-penetrating arterioles, which may be related to reduced nitric oxide- and excess reactive oxygen species-mediated vascular endothelial dysfunction.	Oxygen	208-214	kininogen 1	Homo sapiens	80-90
35594663-4	2022	Subsequent density functional theory (DFT) calculations revealed that the high adsorption capacity for Th(IV) originated from the oxygen-containing groups and their adjacent activated sp2 carbon atoms.	Oxygen	130-136	Sp2 transcription factor	Homo sapiens	184-187
35594451-8	2022	HIF-1alpha protein localised to the nuclei of the cytotrophoblasts and stromal cells in the explants exposed to CoCl2 or 1% O2.	Oxygen	124-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
35583079-3	2022	Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen.	Oxygen	163-169	fibrinogen beta chain	Homo sapiens	247-257
35628301-0	2022	Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
35588210-3	2022	By using a rat model of neonatal high-oxygen (80%O2) exposure, mimicking the premature hyperoxic transition to the extrauterine environment, we revealed a major role of the renin-angiotensin system peptide Angio II (angiotensin II) and its receptor AT1 (angiotensin receptor type 1) on neonatal O2-induced cardiomyopathy.	Oxygen	295-297	angiotensinogen	Rattus norvegicus	216-230
35179151-3	2022	Using hydrogen peroxide, Compound I of CYP152A1 could not be observed, due to its swift decomposition via catalase activity, where Compound I reacts with another molecule of hydrogen peroxide to form O2.	Oxygen	200-202	catalase	Homo sapiens	106-114
35574675-4	2022	Phosphorylation levels of p53 was assessed using immunoblotting at sites known to be phosphorylated (Serine 15 and 37) in response to DNA damage or reduced oxygen signaling.	Oxygen	156-162	tumor protein p53	Homo sapiens	26-29
35574675-11	2022	The results suggest that p53 might play a protective role in crayfish defense against low oxygen stress.	Oxygen	90-96	tumor protein p53	Homo sapiens	25-28
35628301-3	2022	Volumetric (oxygenation) studies were carried out to determine the uptake of molecular oxygen O2 in the formation of the complexes Co(II)-Hpop and Co(II)-Hpoa.	Oxygen	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35628301-3	2022	Volumetric (oxygenation) studies were carried out to determine the uptake of molecular oxygen O2 in the formation of the complexes Co(II)-Hpop and Co(II)-Hpoa.	Oxygen	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35592612-3	2022	In this paper, we report real-time oxygen uptake and medium acidification data that we use to quantify acute insulin effects on intracellular ATP supply and ATP demand in rat and human skeletal muscle cells.	Oxygen	35-41	insulin	Homo sapiens	109-116
35634326-0	2022	Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1alpha Axis in Chronic Obstructive Pulmonary Disease.	Oxygen	0-6	epidermal growth factor receptor	Homo sapiens	64-96
35549905-8	2022	RESULTS: Twenty percent of serum collected from patients undergoing OLV downregulated the expression of Prdx6, leading to the activation of the NF-kappaB signaling pathway, which was associated with the subsequent overproduction of inflammatory cytokines and reactive oxygen species.	Oxygen	268-274	nuclear factor kappa B subunit 1	Homo sapiens	144-153
35634326-0	2022	Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1alpha Axis in Chronic Obstructive Pulmonary Disease.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-128
35634326-7	2022	Hypoxia (5% oxygen) increased the expression of EGFR, CXCR4, CTGF, and HIF-1alpha, the number and differentiation in fibrocytes.	Oxygen	12-18	epidermal growth factor receptor	Homo sapiens	48-52
35634326-7	2022	Hypoxia (5% oxygen) increased the expression of EGFR, CXCR4, CTGF, and HIF-1alpha, the number and differentiation in fibrocytes.	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
35594815-5	2022	TP53 interacts with the majority of lung disease-related genes and regulates important and commonly occurring biological functions and pathways, including gland development, aging, reactive oxygen species metabolic process, the response to oxygen levels, and fluid shear stress, among others.	Oxygen	240-246	tumor protein p53	Homo sapiens	0-4
35580499-7	2022	Finally, the expression of genes related to ABA synthesis (AAO3, MCSU, and NCED3) and the activities of antioxidant enzymes (SOD, POD and CAT) were all reduced in anac004 mutants, leading to reduced levels of endogenous ABA and increased accumulation of reactive oxygen species (O2.- and H2O2) and MDA, which ultimately weakened resistance to Cd.	Oxygen	279-281	NAC domain containing protein 4	Arabidopsis thaliana	163-170
35567930-0	2022	Benzo(a)pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production.	Oxygen	106-112	aryl-hydrocarbon receptor	Mus musculus	62-87
35592530-1	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a major transcription factor that adapts to low oxygen homeostasis and regulates the expression of several hypoxic genes, which aid in cancer survival and development.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
35592530-1	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a major transcription factor that adapts to low oxygen homeostasis and regulates the expression of several hypoxic genes, which aid in cancer survival and development.	Oxygen	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35513370-9	2022	In in vitro experiments, it was verified that NAC can promote the nuclear translocation of Nrf2, which transcriptionally activates the expression of superoxide dismutase and glutathione peroxidase, which removed excessive reactive oxygen species that causes mitochondria damage.	Oxygen	231-237	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
35630540-5	2022	By activating antioxidant enzymes such as superoxide dismutases (SOD), catalase (CAT) and phenylalanine ammonia-lyase (PAL) and subsequently eliminating reactive oxygen species (ROS) in a timely manner, the rate of O-2 production and H2O2 content of wheat seedlings were reduced, and the dynamic balance of free radical metabolism in the plant body was maintained.	Oxygen	215-218	catalase	Homo sapiens	71-79
35630540-5	2022	By activating antioxidant enzymes such as superoxide dismutases (SOD), catalase (CAT) and phenylalanine ammonia-lyase (PAL) and subsequently eliminating reactive oxygen species (ROS) in a timely manner, the rate of O-2 production and H2O2 content of wheat seedlings were reduced, and the dynamic balance of free radical metabolism in the plant body was maintained.	Oxygen	215-218	catalase	Homo sapiens	81-84
35534502-5	2022	The identification of HIF-3alpha as a selective lipid sensor is consistent with recent human genetic findings linking HIF-3alpha with obesity, and demonstrates that endogenous metabolites can directly interact with HIF-alpha proteins to modulate their activities, potentially as a regulatory mechanism supplementary to the well-known oxygen-dependent HIF-alpha hydroxylation.	Oxygen	334-340	hypoxia inducible factor 3 subunit alpha	Homo sapiens	22-32
35510396-3	2022	Release of soluble O2 from H2 O2 by catalase is promising, but spatiotemporal control of the process is challenging to achieve.	Oxygen	19-21	catalase	Homo sapiens	36-44
35510396-4	2022	Here, we show monitoring and control by optical sensing within a porous carrier of the soluble O2 formed by an immobilized catalase upon feeding of H2 O2 .	Oxygen	95-97	catalase	Homo sapiens	123-131
35510396-5	2022	The internally released O2 is used to drive the reaction of D-amino acid oxidase (oxidation of D-methionine) that is co-immobilized with the catalase in the same carrier.	Oxygen	24-26	catalase	Homo sapiens	141-149
35630540-5	2022	By activating antioxidant enzymes such as superoxide dismutases (SOD), catalase (CAT) and phenylalanine ammonia-lyase (PAL) and subsequently eliminating reactive oxygen species (ROS) in a timely manner, the rate of O-2 production and H2O2 content of wheat seedlings were reduced, and the dynamic balance of free radical metabolism in the plant body was maintained.	Oxygen	215-218	superoxide dismutase 1	Homo sapiens	42-63
35630540-5	2022	By activating antioxidant enzymes such as superoxide dismutases (SOD), catalase (CAT) and phenylalanine ammonia-lyase (PAL) and subsequently eliminating reactive oxygen species (ROS) in a timely manner, the rate of O-2 production and H2O2 content of wheat seedlings were reduced, and the dynamic balance of free radical metabolism in the plant body was maintained.	Oxygen	215-218	superoxide dismutase 1	Homo sapiens	65-68
35477242-3	2022	Herein, a PtBi-beta-CD-Ce6 nanoplatform for the generation of sustained O2 was constructed for more effective tumor therapy.	Oxygen	72-74	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	15-22
35477242-4	2022	In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with beta-cyclodextrin (beta-CD).	Oxygen	89-91	catalase	Homo sapiens	15-23
35477242-4	2022	In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with beta-cyclodextrin (beta-CD).	Oxygen	89-91	catalase	Homo sapiens	25-28
35477242-4	2022	In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with beta-cyclodextrin (beta-CD).	Oxygen	89-91	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-137
35477242-5	2022	O2 would be converted into 1O2 by PtBi-beta-CD-Ce6 for enhanced photodynamic therapy (PDT) under 650 nm laser irradiation.	Oxygen	0-2	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	39-46
35500221-7	2022	Interestingly, inhibition of NAMPT in healthy monocytes completely abrogated the IFNgamma-induced oxygen consumption, comparable to levels observed in CGD monocytes.	Oxygen	98-104	interferon gamma	Homo sapiens	81-89
35416037-5	2022	Combining molecular techniques and kinetic verification, we reveal that dominant inhibitions in oxygen-limited environments can interestingly undergo triple detoxification by cryptic sulfur and oxygen cycling, which may extensively occur in nature but have been long neglected by researchers.	Oxygen	96-102	cripto, FRL-1, cryptic family 1	Homo sapiens	175-182
35524714-6	2022	Subsequent diversification of rhodopsin functions and peak absorption frequencies was enabled by the expansion of surface ecological niches induced by the accumulation of atmospheric oxygen.	Oxygen	183-189	rhodopsin	Homo sapiens	30-39
35629169-1	2022	HIF-1alpha is a master regulator of oxygen homeostasis involved in different stages of cancer development.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
35507602-9	2022	Increased levels of mitochondrial complexes II and IV and decreased levels of NRF2, a potent regulator of reactive oxygen species, were also apparent in the brains of SARM1KO mice when compared to wild-type mice.	Oxygen	115-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
35507602-9	2022	Increased levels of mitochondrial complexes II and IV and decreased levels of NRF2, a potent regulator of reactive oxygen species, were also apparent in the brains of SARM1KO mice when compared to wild-type mice.	Oxygen	115-121	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	167-172
35500221-3	2022	We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase.	Oxygen	33-39	interferon gamma	Homo sapiens	14-22
35500221-3	2022	We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase.	Oxygen	101-107	interferon gamma	Homo sapiens	14-22
35085740-13	2022	Hemoglobin-oxygen saturation and vessels diameter dropped faster in LAP than in HAP mice following a 20% ethanol IP injection (3g/kg), with a 32% reduction in cerebrovascular diameter in a half hour period.	Oxygen	11-17	eye lens aplasia	Mus musculus	68-71
35104391-0	2022	Oxygen Ion Implantation Improving Cell Adhesion on Titanium Surfaces through Increased Attraction of Fibronectin PHSRN Domain.	Oxygen	0-6	fibronectin 1	Homo sapiens	101-112
35192691-7	2022	In HMECs, VEGF enhanced mitochondrial function as indicated by elevation in oxygen consumption rate and extracellular acidification rate.	Oxygen	76-82	vascular endothelial growth factor A	Homo sapiens	10-14
35474599-5	2022	Deactivated AMPK induces metabolic dysregulation, mitochondrial fragmentation, and reactive oxygen species formation, leading to the activation of the NLRP3 inflammasome.	Oxygen	92-98	NLR family pyrin domain containing 3	Homo sapiens	151-156
35405266-7	2022	The MuSCs of IUGR newborns activate the Nrf2/SIRT1/PGC1alpha network by taking in DMG-Na, thereby neutralizing excessive generated O2 - that may help to improve their unfavorable mitochondrial dysfunction in skeletal muscle.	Oxygen	131-135	PPARG coactivator 1 alpha	Homo sapiens	51-60
35394023-3	2022	Mitochondrial (mt)ROS, as the superoxide anion (O2.-) generated during mitochondrial respiration, are eliminated in the young organism by antioxidant defense mechanisms, including superoxide dismutase (SOD) 2, whose expression and activity are decreased in aging mesenchymal progenitor cells, accompanied by increased mtROS production.	Oxygen	48-50	superoxide dismutase 2, mitochondrial	Mus musculus	180-208
35043013-4	2022	The knockout of TRPV1 in UCP1 knockout mice further reduced functional brown adipose tissue (BAT) generation; decreased resting oxygen consumption, heat production, and locomotor activities; and was accompanied by severe mitochondrial respiratory dysfunction in BAT.	Oxygen	128-134	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	16-21
35051718-5	2022	It promoted the redox equilibrium of Ce4+ + Sn2+   Ce3+ + Sn4+ shifting to right to produce adequate Ce3+ and surface adsorbed oxygen, resulting in optimal reducibility and surface acidity of Ce/Sn/Ti(imp) catalyst.	Oxygen	127-133	solute carrier family 38 member 5	Homo sapiens	44-47
35058572-13	2022	Knockdown of DLEU2 significantly decreased the protein level of cytochrome-c oxidase (complex IV, MTCO1) without altering other mitochondrial complexes, decreased mitochondrial membrane potential, decreased ATP, and increased reactive oxygen species.	Oxygen	235-241	deleted in lymphocytic leukemia 2	Homo sapiens	13-18
35405266-7	2022	The MuSCs of IUGR newborns activate the Nrf2/SIRT1/PGC1alpha network by taking in DMG-Na, thereby neutralizing excessive generated O2 - that may help to improve their unfavorable mitochondrial dysfunction in skeletal muscle.	Oxygen	131-135	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
35240317-1	2022	Exercise tolerance appears to benefit most from dietary nitrate (NO3-) supplementation when muscle oxygen (O2) availability is low.	Oxygen	107-109	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
35123243-1	2022	A novel and disposable biosensor based on superoxide dismutase (SOD) immobilized on gold metallized polycaprolactone electrospun polymeric fibers (PCl/Au) has been developed for the determination of superoxide (O2 -) in cell culture media.	Oxygen	211-215	superoxide dismutase 1	Homo sapiens	42-62
35373522-4	2022	Herein, defect-rich molybdenum disulfide nanosheets loaded with bovine serum albumin-modified gold nanoparticle (MoS2 @Au@BSA NSs) heterostructures are designed and anchored onto injectable hydrogels to promote diabetic wound healing through an O2 self-supplying cascade reaction.	Oxygen	245-247	albumin	Homo sapiens	71-84
35123243-1	2022	A novel and disposable biosensor based on superoxide dismutase (SOD) immobilized on gold metallized polycaprolactone electrospun polymeric fibers (PCl/Au) has been developed for the determination of superoxide (O2 -) in cell culture media.	Oxygen	211-215	superoxide dismutase 1	Homo sapiens	64-67
35490194-4	2022	MCU knockdown resulted in impaired mitochondrial calcium uptake and a reduction in mitochondrial reactive oxygen species (mROS) levels.	Oxygen	106-112	mitochondrial calcium uniporter	Homo sapiens	0-3
35481813-4	2022	RESULTS: Endogenous AHR knockout alleviated reactive oxygen species accumulation and neuronal apoptosis in ipsilateral hemisphere at 48h after ICH in mice.	Oxygen	53-59	aryl-hydrocarbon receptor	Mus musculus	20-23
35488217-0	2022	Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-kappaB axis.	Oxygen	27-33	toll-like receptor 4	Rattus norvegicus	111-115
35174599-3	2022	Hf-PSP-DTC@PLX elicited a high imaging performance for precise RT and generated H2S to reduce cellular oxygen consumption rate via mitochondrial respiration inhibiting, which reprogrammed oxygen metabolism for tumor oxygenation improvement.	Oxygen	103-109	persephin	Homo sapiens	3-6
35528614-2	2022	Hypoxia-inducible factor 1 (HIF-1) serves as one of the most important factors of oxygen balance transcription.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
35528614-2	2022	Hypoxia-inducible factor 1 (HIF-1) serves as one of the most important factors of oxygen balance transcription.	Oxygen	82-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
35404120-7	2022	Transcriptional profiling of Histoplasma yeasts identified a small regulon of Mac1-dependent genes, with the most strongly regulated genes encoding proteins linked to copper, iron, and zinc homeostasis and defenses against reactive oxygen (iron-requiring catalase (CatB) and superoxide dismutase (Sod4)).	Oxygen	232-238	Mac1p	Saccharomyces cerevisiae S288C	78-82
35174599-3	2022	Hf-PSP-DTC@PLX elicited a high imaging performance for precise RT and generated H2S to reduce cellular oxygen consumption rate via mitochondrial respiration inhibiting, which reprogrammed oxygen metabolism for tumor oxygenation improvement.	Oxygen	188-194	persephin	Homo sapiens	3-6
35470547-1	2022	Titanate nanotube (TNT) was coated with the cyclic oligosaccharides (carboxymethyl-beta-cyclodextrin, CM-beta-CD) to obtain a photocatalyst (CM-beta-CD-TNT) for efficiently activating molecular oxygen and removing the target contaminant.	Oxygen	194-200	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	105-112
35470547-1	2022	Titanate nanotube (TNT) was coated with the cyclic oligosaccharides (carboxymethyl-beta-cyclodextrin, CM-beta-CD) to obtain a photocatalyst (CM-beta-CD-TNT) for efficiently activating molecular oxygen and removing the target contaminant.	Oxygen	194-200	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	144-151
35522490-2	2022	A transition from the body-centered-cubic (bcc) to face-centered-cubic (fcc) oxygen atoms sublattices is observed from 57 GPa and 1500 K to 166 GPa and 2500 K. That is the structural signature of the transition to fcc superionic (fcc SI) ice.	Oxygen	77-83	glycophorin A (MNS blood group)	Homo sapiens	122-125
35522490-2	2022	A transition from the body-centered-cubic (bcc) to face-centered-cubic (fcc) oxygen atoms sublattices is observed from 57 GPa and 1500 K to 166 GPa and 2500 K. That is the structural signature of the transition to fcc superionic (fcc SI) ice.	Oxygen	77-83	glycophorin A (MNS blood group)	Homo sapiens	144-147
35449452-0	2022	Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma.	Oxygen	56-62	intercellular adhesion molecule 1	Felis catus	10-16
35452683-1	2022	Egg laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 alpha (HIF1alpha) under normoxia conditions, leading to its proteasomal degradation.	Oxygen	52-58	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-27
35411772-2	2022	The Lorentz-Berthelot combining rules were adopted for the unlike-pair interactions of Na+, Cl-, and the oxygen site in SPC/E water, and geometric combining rules were utilized for the remainder of the cross interactions.	Oxygen	105-111	surfactant protein C	Homo sapiens	120-123
35452683-1	2022	Egg laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 alpha (HIF1alpha) under normoxia conditions, leading to its proteasomal degradation.	Oxygen	52-58	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-34
35452683-1	2022	Egg laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 alpha (HIF1alpha) under normoxia conditions, leading to its proteasomal degradation.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-159
35452683-1	2022	Egg laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 alpha (HIF1alpha) under normoxia conditions, leading to its proteasomal degradation.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-170
35452683-4	2022	Notably, we demonstrate that the methylation mimic mutant of EGLN1 loses the capability to suppress the hypoxia signaling pathway, leading to the enhancement of cell proliferation and the oxygen consumption rate.	Oxygen	188-194	egl-9 family hypoxia inducible factor 1	Homo sapiens	61-66
35625671-9	2022	The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients.	Oxygen	115-121	CD33 molecule	Homo sapiens	25-29
35625671-9	2022	The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients.	Oxygen	115-121	interleukin 6	Homo sapiens	58-62
35625671-9	2022	The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients.	Oxygen	162-168	CD33 molecule	Homo sapiens	25-29
35625671-9	2022	The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients.	Oxygen	162-168	interleukin 6	Homo sapiens	58-62
35296453-7	2022	The lead inhibitor interacted with FAAH and MAGL via pi-pi stacking via phenyl ring and hydrogen bonding through sulfonyl oxygen atoms or amide NH.	Oxygen	122-128	fatty acid amide hydrolase	Homo sapiens	35-39
35631320-9	2022	Heme-mediated Nrf2 activation was dependent on the production of reactive oxygens species.	Oxygen	74-81	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
35219731-2	2022	Hypoxia inducible factor-1alpha (HIF-1alpha) is reported to be a key factor in fracture healing, and is degraded by hydroxylation of prolyl hydroxylase (PHDs) under normal oxygen.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
35219731-2	2022	Hypoxia inducible factor-1alpha (HIF-1alpha) is reported to be a key factor in fracture healing, and is degraded by hydroxylation of prolyl hydroxylase (PHDs) under normal oxygen.	Oxygen	172-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35565979-4	2022	The hybrid nanoparticles utilize the catalytic decomposition of endogenous H2O2 to produce oxygen for the downregulation of the hypoxia-inducible factor 1 subunit alpha (HIF-1alpha) protein, which could reverse the tumor hypoxic microenvironment.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	170-180
35509994-6	2022	In the molecular model of human MBOAT7, Glu253 in the wild-type protein is located close to the backbone carbonyl oxygens in the loop near the helix, suggesting that the ionic interaction could contribute to the conformational stability of the funnel.	Oxygen	114-121	membrane bound O-acyltransferase domain containing 7	Homo sapiens	32-38
35363463-2	2022	Herein, a highly emissive oxygen-doped carbon nitride composite (OCNP@M7) was synthesized, with a metal-azolate framework (MAF-7) serving as a luminous booster.	Oxygen	26-32	MAF bZIP transcription factor	Homo sapiens	123-126
34998196-6	2022	X-ray photoelectron spectroscopy (XPS), solid-state nuclear magnetic resonance (ssNMR) and X-ray absorption near-edge structure (XANES) spectroscopy reveal that the carbon and oxygen dopants replace the sp2 nitrogen and bridging N atom, respectively.	Oxygen	176-182	Sp2 transcription factor	Homo sapiens	203-206
35167880-0	2022	Hyperbaric oxygen therapy mitigates left ventricular remodeling, upregulates MMP-2 and VEGF, and inhibits the induction of MMP-9, TGF-beta1, and TNF-alpha in streptozotocin-induced diabetic rat heart.	Oxygen	11-17	transforming growth factor, beta 1	Rattus norvegicus	130-139
35167880-0	2022	Hyperbaric oxygen therapy mitigates left ventricular remodeling, upregulates MMP-2 and VEGF, and inhibits the induction of MMP-9, TGF-beta1, and TNF-alpha in streptozotocin-induced diabetic rat heart.	Oxygen	11-17	tumor necrosis factor	Rattus norvegicus	145-154
35457152-3	2022	Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species.	Oxygen	247-253	insulin	Homo sapiens	0-7
35296158-8	2022	Analysis of mitochondrial metabolism revealed that microRNA-210 inhibited mitochondrial oxygen consumption, increased glycolytic activity, and reduced mitochondrial ROS flux in the heart during IR injury.	Oxygen	88-94	microRNA 210	Mus musculus	51-63
35363463-3	2022	Both experimental studies and theoretical calculations suggest that the MAF-enhanced electron-donating effect dramatically promoted the electron density on the pi-structure of oxygen-doped carbon nitride.	Oxygen	176-182	MAF bZIP transcription factor	Homo sapiens	72-75
35413712-11	2022	Univariate and multiple logistic regression analysis showed that serum TF level emerged as a significant and independent factor associated with OSA severity especially grouped by oxygen desaturation index (ODI) (odds ratio: 2.91, 95% CI: 1.36-6.23, p = 0.006).	Oxygen	179-185	transferrin	Homo sapiens	71-73
35414060-0	2022	Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage.	Oxygen	161-167	thioredoxin interacting protein	Homo sapiens	99-104
35411936-7	2022	In hypoxia, cAMP switched targets and suppressed hypoxia-inducible factor 1alpha, a master regulator of VEGFA/angiogenesis in low oxygen environments.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-80
35411936-7	2022	In hypoxia, cAMP switched targets and suppressed hypoxia-inducible factor 1alpha, a master regulator of VEGFA/angiogenesis in low oxygen environments.	Oxygen	130-136	vascular endothelial growth factor A	Homo sapiens	104-109
35415998-5	2022	Oxygen uptake-related variables, including respiratory exchange ratio, heart rate, plasma glucose, insulin, glucagon, free fatty acids, blood lactate concentrations, gastrointestinal discomfort and rate of perceived exertion were measured.	Oxygen	0-6	insulin	Homo sapiens	99-106
35093426-5	2022	Additionally, enhanced glucose uptake was detected in Cx43-overexpressing spheroids, along with upregulated mTOR, downregulated AMPK signaling, increased ATP content, and enhanced oxygen consumption rate.	Oxygen	180-186	gap junction protein, alpha 1	Mus musculus	54-58
35354284-2	2022	The resulting 1-Py/KB40 (KB = Ketjen black) shows an increased oxygen evolution reaction (OER) performance with an overpotential of 370 mV at a current density of 10 mA cm-2 and a Tafel slope of 58 mV dec-1.	Oxygen	63-69	keratin 78	Homo sapiens	19-23
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	Oxygen	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	Oxygen	142-148	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	110-117
35358381-4	2022	Herein, we report the initial synthesis and study of a Co(II) tetrapyrrole complex based on a nonaromatic isocorrole scaffold that is competent for 4e-/4H+ oxygen reduction reaction (ORR).	Oxygen	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Oxygen	246-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35379149-11	2022	Amyloid-beta triggers cholinergic loss by modulation of calcium and generation of cell-damaging molecules such as nitric oxide and reactive oxygen species intermediates.	Oxygen	140-146	amyloid beta precursor protein	Homo sapiens	0-12
35389415-5	2022	The CM NCs exhibited excellent superoxide dismutase (SOD) and catalase (CAT) mimetic activity to scavenge ROS and generate oxygen (O2).	Oxygen	123-129	superoxide dismutase 1	Homo sapiens	53-56
35389415-5	2022	The CM NCs exhibited excellent superoxide dismutase (SOD) and catalase (CAT) mimetic activity to scavenge ROS and generate oxygen (O2).	Oxygen	123-129	catalase	Homo sapiens	72-75
35389415-5	2022	The CM NCs exhibited excellent superoxide dismutase (SOD) and catalase (CAT) mimetic activity to scavenge ROS and generate oxygen (O2).	Oxygen	131-133	superoxide dismutase 1	Homo sapiens	53-56
35389415-5	2022	The CM NCs exhibited excellent superoxide dismutase (SOD) and catalase (CAT) mimetic activity to scavenge ROS and generate oxygen (O2).	Oxygen	131-133	catalase	Homo sapiens	62-70
35389415-5	2022	The CM NCs exhibited excellent superoxide dismutase (SOD) and catalase (CAT) mimetic activity to scavenge ROS and generate oxygen (O2).	Oxygen	131-133	catalase	Homo sapiens	72-75
35202675-0	2022	Suppression of the doxorubicin response by hypoxia-inducible factor-1alpha is strictly dependent on oxygen concentrations under hypoxic conditions.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-74
35202675-4	2022	At 5% O2, the drugs decreased HIF-1alpha expression and increased p53 levels.	Oxygen	6-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
35202675-4	2022	At 5% O2, the drugs decreased HIF-1alpha expression and increased p53 levels.	Oxygen	6-8	tumor protein p53	Homo sapiens	66-69
35202675-5	2022	At 1% O2, the drugs increased HIF-1alpha expression but did not alter p53 levels.	Oxygen	6-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
35202675-8	2022	We hypothesized the mechanism of HIF-1alpha protein translation might be different between at 5% and at 1% O2, because many reports indicate that the same mechanism of HIF-1alpha protein stabilization occurs under hypoxic conditions, such as 5% and 1% O2.	Oxygen	107-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35202675-8	2022	We hypothesized the mechanism of HIF-1alpha protein translation might be different between at 5% and at 1% O2, because many reports indicate that the same mechanism of HIF-1alpha protein stabilization occurs under hypoxic conditions, such as 5% and 1% O2.	Oxygen	107-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-178
35202675-8	2022	We hypothesized the mechanism of HIF-1alpha protein translation might be different between at 5% and at 1% O2, because many reports indicate that the same mechanism of HIF-1alpha protein stabilization occurs under hypoxic conditions, such as 5% and 1% O2.	Oxygen	252-254	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35202675-8	2022	We hypothesized the mechanism of HIF-1alpha protein translation might be different between at 5% and at 1% O2, because many reports indicate that the same mechanism of HIF-1alpha protein stabilization occurs under hypoxic conditions, such as 5% and 1% O2.	Oxygen	252-254	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-178
35202675-9	2022	The level of phosphorylated-4E-BP1, which causes translation of HIF-1alpha, was higher at 1% O2 than at 5% O2.	Oxygen	93-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
35202675-9	2022	The level of phosphorylated-4E-BP1, which causes translation of HIF-1alpha, was higher at 1% O2 than at 5% O2.	Oxygen	107-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
35455951-6	2022	Investigation of beta3-AR regulation over OIR progression revealed that the expression profile of beta3-AR depends on oxygen tension, similar to VEGF.	Oxygen	118-124	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	17-22
35455951-6	2022	Investigation of beta3-AR regulation over OIR progression revealed that the expression profile of beta3-AR depends on oxygen tension, similar to VEGF.	Oxygen	118-124	adenosine A3 receptor	Mus musculus	98-106
35455951-7	2022	The additional evidence that HIF-1alpha stabilization decouples beta3-AR expression from oxygen levels further indicates that HIF-1 regulates the expression of the beta3-AR gene in the retina.	Oxygen	89-95	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	164-169
35453414-7	2022	The SOD and POX activities appeared closely related, and related to the NADH oxidation and the amount of O2-.	Oxygen	105-108	superoxide dismutase 1	Homo sapiens	4-7
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	AKT serine/threonine kinase 1	Homo sapiens	157-160
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	268-272
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	288-294
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Oxygen	169-175	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	470-474
35199359-2	2022	Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood.	Oxygen	126-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
35236105-7	2022	In addition, retroviral-mediated overexpression of CDC6 rescued oxygen-induced retinopathy-induced retinal neovascularization from inhibition in PLCbeta3 knockout mice and in endothelial cell-specific NFATc1-deficient mice.	Oxygen	64-70	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	201-207
35114372-7	2022	Concurrently, CAT safely decomposed the produced H2O2 with systemic toxicity to promote oxygen generation and achieved low toxicity starvation therapy.	Oxygen	88-94	catalase	Homo sapiens	14-17
35114372-12	2022	Herein, an oxygen self-supplied and tumor tissue-targeted enzyme nanogel was created by copolymerization of two monomers, porphyrin and cancer cell-targeted Arg-Gly-Asp (RGD), onto the surface of glucose oxidase (GOX) and catalase (CAT), which synergistically enhanced starvation therapy and PDT.	Oxygen	11-17	catalase	Homo sapiens	232-235
35515703-1	2022	Vitamin B12 (B12) is an essential co-factor for two enzymes in mammalian metabolism and can also act as a mimetic of superoxide dismutase (SOD) converting superoxide (O2  -) to hydrogen peroxide (H2O2).	Oxygen	167-172	superoxide dismutase 1	Homo sapiens	117-137
35515703-1	2022	Vitamin B12 (B12) is an essential co-factor for two enzymes in mammalian metabolism and can also act as a mimetic of superoxide dismutase (SOD) converting superoxide (O2  -) to hydrogen peroxide (H2O2).	Oxygen	167-172	superoxide dismutase 1	Homo sapiens	139-142
35133042-5	2022	After tumor cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation of the nanoplatform and the released CAT catalyzes hydrogen peroxide (H2 O2 ) to produce O2 to relieve tumor hypoxia.	Oxygen	179-181	catalase	Homo sapiens	127-130
35236105-8	2022	CONCLUSIONS: The above observations clearly reveal that PLCbeta3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.	Oxygen	148-154	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	74-80
35190865-1	2022	PURPOSE: Our aim was to determine the effect of repeated sprint exercise in hypoxia on HIF-1 and HIF-1-regulated genes involved in glycolysis, mitochondrial turnover and oxygen transport.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-92
35406578-7	2022	We showed that under a low-oxygen culture condition and nutrient deprivation, the CD44+/CD24- population is enriched.	Oxygen	27-33	CD24 molecule	Homo sapiens	88-92
35193096-0	2022	APOE gene polymorphism alters cerebral oxygen saturation and quantitative EEG in early-stage traumatic brain injury.	Oxygen	39-45	apolipoprotein E	Homo sapiens	0-4
35193096-1	2022	OBJECTIVE: To investigate the influence of apolipoprotein E (APOE) gene polymorphism on regional cerebral oxygen saturation (rScO2) and quantitative electroencephalogram (QEEG) at the early phase of adult traumatic brain injury (TBI).	Oxygen	106-112	apolipoprotein E	Homo sapiens	43-59
35190865-1	2022	PURPOSE: Our aim was to determine the effect of repeated sprint exercise in hypoxia on HIF-1 and HIF-1-regulated genes involved in glycolysis, mitochondrial turnover and oxygen transport.	Oxygen	170-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-102
34472482-7	2022	Further experiments revealed that mir-181c-5p overexpression reversed the effect of MEG3 on autophagy and ATG7 expression in HT22 cells subjected to oxygen and glucose deprivation/reoxygenation.	Oxygen	149-155	autophagy related 7	Mus musculus	106-110
35234273-3	2022	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in regulating cellular adaptation to low oxygen conditions.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
35234273-3	2022	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a key role in regulating cellular adaptation to low oxygen conditions.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35247490-4	2022	More importantly, the nanocarrier could enhance the cascade reaction between SOD and CAT, which converts the superoxide anion to oxygen.	Oxygen	129-135	catalase	Mus musculus	85-88
35321878-6	2022	A shortened analog of PSMalpha2 (PSMalpha21-12), lacking the nine C-terminal residues, activated both FPR1 and FPR2 to produce reactive oxygen species, whereas beta-arrestin recruitment was only mediated through FPR1.	Oxygen	136-142	proteasome 20S subunit alpha 2	Homo sapiens	22-31
35321878-6	2022	A shortened analog of PSMalpha2 (PSMalpha21-12), lacking the nine C-terminal residues, activated both FPR1 and FPR2 to produce reactive oxygen species, whereas beta-arrestin recruitment was only mediated through FPR1.	Oxygen	136-142	formyl peptide receptor 1	Homo sapiens	102-106
35093630-0	2022	MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.	Oxygen	19-25	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
35093630-0	2022	MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.	Oxygen	19-25	fibroblast growth factor 9	Rattus norvegicus	145-149
35189109-3	2022	EN460, an inhibitor of ERO1 alpha, recapitulated all the effects associated with RyR inhibition or downregulation, including prevention of RyR-induced Ca2+ accumulation in mitochondria and the resulting O2-.	Oxygen	203-206	ryanodine receptor 2	Homo sapiens	81-84
35189109-3	2022	EN460, an inhibitor of ERO1 alpha, recapitulated all the effects associated with RyR inhibition or downregulation, including prevention of RyR-induced Ca2+ accumulation in mitochondria and the resulting O2-.	Oxygen	203-206	ryanodine receptor 2	Homo sapiens	139-142
35343597-9	2022	High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non-invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9).	Oxygen	10-16	EP300 interacting inhibitor of differentiation 2	Homo sapiens	254-259
34472490-1	2022	HOXA transcript at the distal tip (HOTTIP), a newly identified long noncoding RNA, has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal apoptosis.	Oxygen	147-153	homeobox A cluster	Mus musculus	0-4
35294713-0	2022	Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice.	Oxygen	23-29	itchy, E3 ubiquitin protein ligase	Mus musculus	63-67
35091982-4	2022	Upon establishing the oxygen-glucose deprivation/reperfusion (OGD/R) cell model, changes of Sirt3 protein levels and the effects of Sirt3 overexpression on primary hippocampal neurons were detected at indicated time points.	Oxygen	22-28	sirtuin 3	Homo sapiens	92-97
35091982-4	2022	Upon establishing the oxygen-glucose deprivation/reperfusion (OGD/R) cell model, changes of Sirt3 protein levels and the effects of Sirt3 overexpression on primary hippocampal neurons were detected at indicated time points.	Oxygen	22-28	sirtuin 3	Homo sapiens	132-137
35107086-2	2022	OBJECTIVE: To analyze the brain tissue oxygen tension through the process by which anterograde arterial blood flow is re-established after temporary clipping (TR).	Oxygen	39-45	coagulation factor II thrombin receptor	Homo sapiens	159-161
35294713-0	2022	Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice.	Oxygen	23-29	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	72-112
35409227-8	2022	Given that O2 - plays roles in maintaining WUS expression and stem cell activity, we speculate that the dynamic shift from O2 - to H2O2 in the shoot apex results in stem cell death.	Oxygen	11-13	Homeodomain-like superfamily protein	Arabidopsis thaliana	43-46
35332670-0	2022	Intelligent Nanodelivery System-Generated 1 O2 Mediates Tumor Vessel Normalization by Activating Endothelial TRPV4-eNOS Signaling.	Oxygen	44-46	nitric oxide synthase 3	Homo sapiens	115-119
35409227-8	2022	Given that O2 - plays roles in maintaining WUS expression and stem cell activity, we speculate that the dynamic shift from O2 - to H2O2 in the shoot apex results in stem cell death.	Oxygen	123-125	Homeodomain-like superfamily protein	Arabidopsis thaliana	43-46
35361857-8	2022	Both apoA1 transduction conditions similarly inhibited basal and TNFalpha-induced reactive oxygen species in rat aortic endothelial cells (RAEC) and resulted in the reduced rat monocyte attachment to the TNFalpha-activated endothelium.	Oxygen	91-97	tumor necrosis factor	Rattus norvegicus	65-73
35266499-6	2022	In this review, we discuss the active site environment, electronic structure, spectroscopic and electrochemical properties, and some interesting reactivities exhibited by the heme-Cu-Abeta complex with small molecules, such as oxygen (O2), nitric oxide (NO) and nitrite (NO2-).	Oxygen	227-233	amyloid beta precursor protein	Homo sapiens	183-188
35266499-6	2022	In this review, we discuss the active site environment, electronic structure, spectroscopic and electrochemical properties, and some interesting reactivities exhibited by the heme-Cu-Abeta complex with small molecules, such as oxygen (O2), nitric oxide (NO) and nitrite (NO2-).	Oxygen	235-237	amyloid beta precursor protein	Homo sapiens	183-188
35409106-0	2022	Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling.	Oxygen	13-19	mechanistic target of rapamycin kinase	Homo sapiens	98-102
35348035-0	2022	Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period.	Oxygen	126-132	DLG associated protein 2	Rattus norvegicus	62-85
35348035-0	2022	Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period.	Oxygen	126-132	DLG associated protein 2	Rattus norvegicus	87-93
35369032-3	2022	Moreover, the lack of O2 in TME also up-regulates the expression of HIF-1alpha and promotes tumor metastasis, which is also a leading cause of death for terminal cancer patients.	Oxygen	22-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-78
35369032-11	2022	At the same time, the increasing O2 content could also reduce the expression of HIF-1alpha at the tumor site, which could reduce lung metastasis.	Oxygen	33-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
35402516-1	2022	Cu,Zn superoxide dismutase (SOD1) is a 32 kDa homodimer that converts toxic oxygen radicals in neurons to less harmful species.	Oxygen	76-82	superoxide dismutase 1	Homo sapiens	0-26
35402516-1	2022	Cu,Zn superoxide dismutase (SOD1) is a 32 kDa homodimer that converts toxic oxygen radicals in neurons to less harmful species.	Oxygen	76-82	superoxide dismutase 1	Homo sapiens	28-32
35408505-5	2022	The experiments herein describe an anticancer mechanism in which heat shock protein 90 (HSP90) stabilizes HIF-1alpha, a master transcription factor of oxygen homeostasis that has been implicated in the survival, proliferation and malignant progression of cancers.	Oxygen	151-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
35157972-0	2022	Periostin attenuates oxygen and glucose deprivation-induced death of mouse neural stem cells via inhibition of p38 MAPK activation.	Oxygen	21-27	periostin, osteoblast specific factor	Mus musculus	0-9
35157972-3	2022	This study aimed to investigate the neuroprotective effects of POSTN on NSCs injury induced by oxygen and glucose deprivation (OGD).	Oxygen	95-101	periostin, osteoblast specific factor	Mus musculus	63-68
35340325-3	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is plays an important role in the cellular response to systemic oxygen levels of cells and VEGF is an angiogenic factor and can stimulate cellular responses on the surface of endothelial cells will be described.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
35340325-3	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is plays an important role in the cellular response to systemic oxygen levels of cells and VEGF is an angiogenic factor and can stimulate cellular responses on the surface of endothelial cells will be described.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
35340325-3	2022	Hypoxia-inducible factor-1alpha (HIF-1alpha) is plays an important role in the cellular response to systemic oxygen levels of cells and VEGF is an angiogenic factor and can stimulate cellular responses on the surface of endothelial cells will be described.	Oxygen	109-115	vascular endothelial growth factor A	Homo sapiens	136-140
35314293-5	2022	RESULTS: (1) In vitro in solutions containing bovine serum albumin (BSA) the O2 depletion g-values (moles/L of O2 depleted per radiation dose, e.g. muM/Gy) are higher for conventional irradiation (by ~13% at 75 muM (O2)) than for FLASH, and in the low-oxygen region (<25 muM (O2)) they decrease with oxygen concentration.	Oxygen	111-113	albumin	Homo sapiens	53-66
35271272-2	2022	When using the Lewis acid (Mo2(OAc)4) (CAT) as a catalyst, it was found that the activation of CAT by O2 was essential for an efficient reaction.	Oxygen	102-104	catalase	Homo sapiens	39-42
35271272-2	2022	When using the Lewis acid (Mo2(OAc)4) (CAT) as a catalyst, it was found that the activation of CAT by O2 was essential for an efficient reaction.	Oxygen	102-104	catalase	Homo sapiens	95-98
35271272-6	2022	When CAT is activated by O2, CATO2 may be the correct catalytic species, which results in a dramatic increase of reaction activity.	Oxygen	25-27	catalase	Homo sapiens	5-8
35317575-6	2022	The results show that the Mg2+ parameters for SPC/E are transferable to OPC and closely reproduce the experimental solvation free energy, radius of the first hydration shell, coordination number, activity derivative, and binding affinity toward the phosphate oxygens on RNA.	Oxygen	259-266	surfactant protein C	Homo sapiens	46-49
35370552-0	2022	Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy.	Oxygen	23-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
35314293-5	2022	RESULTS: (1) In vitro in solutions containing bovine serum albumin (BSA) the O2 depletion g-values (moles/L of O2 depleted per radiation dose, e.g. muM/Gy) are higher for conventional irradiation (by ~13% at 75 muM (O2)) than for FLASH, and in the low-oxygen region (<25 muM (O2)) they decrease with oxygen concentration.	Oxygen	216-218	albumin	Homo sapiens	53-66
35314293-5	2022	RESULTS: (1) In vitro in solutions containing bovine serum albumin (BSA) the O2 depletion g-values (moles/L of O2 depleted per radiation dose, e.g. muM/Gy) are higher for conventional irradiation (by ~13% at 75 muM (O2)) than for FLASH, and in the low-oxygen region (<25 muM (O2)) they decrease with oxygen concentration.	Oxygen	252-258	albumin	Homo sapiens	53-66
35314293-5	2022	RESULTS: (1) In vitro in solutions containing bovine serum albumin (BSA) the O2 depletion g-values (moles/L of O2 depleted per radiation dose, e.g. muM/Gy) are higher for conventional irradiation (by ~13% at 75 muM (O2)) than for FLASH, and in the low-oxygen region (<25 muM (O2)) they decrease with oxygen concentration.	Oxygen	276-278	albumin	Homo sapiens	53-66
35314293-5	2022	RESULTS: (1) In vitro in solutions containing bovine serum albumin (BSA) the O2 depletion g-values (moles/L of O2 depleted per radiation dose, e.g. muM/Gy) are higher for conventional irradiation (by ~13% at 75 muM (O2)) than for FLASH, and in the low-oxygen region (<25 muM (O2)) they decrease with oxygen concentration.	Oxygen	300-306	albumin	Homo sapiens	53-66
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Oxygen	28-34	heme oxygenase 1	Mus musculus	9-13
35341134-5	2022	High glucose or insulin significantly inhibited glucose uptake and promoted release of reactive oxygen species in GEnCs.	Oxygen	96-102	insulin	Homo sapiens	16-23
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Oxygen	28-34	mitogen-activated protein kinase 1	Mus musculus	43-46
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Oxygen	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
35313640-6	2022	Finally, knockdown of ETFA in endothelial cells also reduced fatty acid oxidation, oxygen consumption rate, and hypoxia-inducible factor-1alpha (HIF1alpha) protein levels.	Oxygen	83-89	electron transfer flavoprotein subunit alpha	Danio rerio	22-26
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	109-111	catalase	Homo sapiens	33-41
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	109-111	catalase	Homo sapiens	43-46
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	157-159	catalase	Homo sapiens	33-41
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	157-159	catalase	Homo sapiens	43-46
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	237-239	catalase	Homo sapiens	33-41
35129963-6	2022	Moreover, the loaded Pt NPs with catalase (CAT)-mimic activity could decompose hydrogen peroxide (H2O2) into O2 within the tumor cells, increasing the local O2 concentration, modulating the tumorous hypoxia atmosphere, and promoting the O2-dependent glucose oxidation reaction.	Oxygen	237-239	catalase	Homo sapiens	43-46
35277579-6	2022	The deficiency of LSD-2 expression enhanced reactive oxygen species production in the salivary gland and promoted JNK-dependent apoptosis by suppressing dMyc expression.	Oxygen	53-59	Lipid storage droplet-2	Drosophila melanogaster	18-23
35247316-4	2022	We report that ATE1 centrally controls the hypoxic response and glycolysis in mammalian cells by preferentially arginylating HIF1alpha that is hydroxylated by PHD in the presence of oxygen.	Oxygen	182-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-134
35387175-7	2022	The CAT catalyzes the endogenous H2O2 into O2 to relieve the hypoxic microenvironment, and the released HA-HMME exhibits a higher ROS generation ability, greatly boosting SDT for the inhibition of tumor growth.	Oxygen	43-45	catalase	Homo sapiens	4-7
35313640-9	2022	This work suggests that disturbance of ETFalpha-mediated oxygen homeostasis is one of the mechanisms behind hypercholesterolemia-induced vascular dysfunction.	Oxygen	57-63	electron transfer flavoprotein subunit alpha	Danio rerio	39-47
35244034-5	2022	The physiological and biochemical indexes, including immune inflammation indicators, electrolytes, myocardial enzyme profile, and functions of liver and kidney, were examined and investigated before and after hydrogen-oxygen therapy.The results showed significant decreases in the neutrophil percentage and the concentration and abnormal proportion of C-reactive protein in COVID-19 patients received additional hydrogen-oxygen therapy.This novel therapeutic may alleviate clinical symptoms of COVID-19 patients by suppressing inflammation responses.	Oxygen	218-224	C-reactive protein	Homo sapiens	352-370
35229603-6	2022	However, under acidic conditions, the CAT biomimetic reaction is hindered owing to the limited reversibility of Ce3+   Ce4+ and formation   annihilation of oxygen vacancies.	Oxygen	156-162	catalase	Homo sapiens	38-41
35356201-2	2022	In a microenvironment, superoxide dismutase 3 (SOD3) can adjust active oxygen, and it refers to a secreted antioxidant enzyme.	Oxygen	71-77	superoxide dismutase 3	Homo sapiens	23-45
35356201-2	2022	In a microenvironment, superoxide dismutase 3 (SOD3) can adjust active oxygen, and it refers to a secreted antioxidant enzyme.	Oxygen	71-77	superoxide dismutase 3	Homo sapiens	47-51
35269514-5	2022	In adult neural stem cells (NSCs), KRGE-treated, astrocyte-conditioned media increased oxygen consumption and Tom20 levels through astrocyte-derived HO-1.	Oxygen	87-93	heme oxygenase 1	Mus musculus	149-153
35337137-4	2022	Herein, we discovered new SIRT1-activating derivatives, characterized by phenolic rings spaced by sulfur, nitrogen or oxygen-based central linkers.	Oxygen	118-124	sirtuin 1	Rattus norvegicus	26-31
35269514-3	2022	In this study, KRGE promoted astrocytic mitochondrial functions, assessed with oxygen consumption and adenosine triphosphate (ATP) production, which could be regulated by the translocase of the outer membrane of mitochondria 20 (Tom20) pathway with a PGC-1alpha-independent pathway.	Oxygen	79-85	translocase of outer mitochondrial membrane 20	Mus musculus	229-234
35170301-2	2022	Nonetheless, the consumption of oxygen during PDT results in serious hypoxic conditions and an elevated hypoxia-inducing factor-1alpha (HIF-1alpha) level that hamper further photodynamic efficacy and induce tumor metastasis.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
35063633-3	2022	We report a cell-based luminescent assay using HeLa cells expressing luciferase-fused oxygen-dependent destruction domain (ODD) of hypoxia-inducible factor 1 alpha (HIF-1 alpha).	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-163
35143446-0	2022	Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells.	Oxygen	123-129	FKBP prolyl isomerase 5	Homo sapiens	100-105
35143449-8	2022	In addition, NACA activated nuclear factor erythroid 2-related factor 2-dependent anti-inflammation signaling, which is well known to affect reactive oxygen species.	Oxygen	150-156	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-71
35063633-3	2022	We report a cell-based luminescent assay using HeLa cells expressing luciferase-fused oxygen-dependent destruction domain (ODD) of hypoxia-inducible factor 1 alpha (HIF-1 alpha).	Oxygen	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	165-176
35142315-5	2022	The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR.	Oxygen	4-10	caveolin 1	Homo sapiens	111-115
35142315-5	2022	The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR.	Oxygen	4-10	caveolin 1	Homo sapiens	122-126
35104011-4	2022	Nrf2 abrogation diminished mitochondrial DNA content in hepatocytes with Ppargc1alpha and Cpt1a inhibition, whereas its overexpression enhanced oxygen consumption.	Oxygen	144-150	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
35148993-5	2022	We show that silencing of DIMT1 in insulin-secreting cells impacted mitochondrial function, leading to lower expression of mitochondrial OXPHOS proteins, reduced oxygen consumption rate, dissipated mitochondrial membrane potential, and a slower rate of ATP production.	Oxygen	162-168	DIM1 rRNA methyltransferase and ribosome maturation factor	Homo sapiens	26-31
35199870-5	2022	In principle, HIF-1alpha is bound directly to the hypoxia response elements (HREs) of the p21 promoter to enhance its transcription activity, in turn, p21 also promoted the transcription of HIF-1alpha at the mRNA level and maintained HIF-1alpha function under oxygen deficiency.	Oxygen	260-266	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
35199870-5	2022	In principle, HIF-1alpha is bound directly to the hypoxia response elements (HREs) of the p21 promoter to enhance its transcription activity, in turn, p21 also promoted the transcription of HIF-1alpha at the mRNA level and maintained HIF-1alpha function under oxygen deficiency.	Oxygen	260-266	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-93
35199870-5	2022	In principle, HIF-1alpha is bound directly to the hypoxia response elements (HREs) of the p21 promoter to enhance its transcription activity, in turn, p21 also promoted the transcription of HIF-1alpha at the mRNA level and maintained HIF-1alpha function under oxygen deficiency.	Oxygen	260-266	cyclin dependent kinase inhibitor 1A	Homo sapiens	151-154
35199870-5	2022	In principle, HIF-1alpha is bound directly to the hypoxia response elements (HREs) of the p21 promoter to enhance its transcription activity, in turn, p21 also promoted the transcription of HIF-1alpha at the mRNA level and maintained HIF-1alpha function under oxygen deficiency.	Oxygen	260-266	hypoxia inducible factor 1 subunit alpha	Homo sapiens	190-200
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	128-130	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	186-191
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	140-142	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	186-191
34999424-5	2022	Moreover, spectroscopic studies suggested the formation of a transient six-coordinated (CoII(NO)(O2-)) species.	Oxygen	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
35148993-5	2022	We show that silencing of DIMT1 in insulin-secreting cells impacted mitochondrial function, leading to lower expression of mitochondrial OXPHOS proteins, reduced oxygen consumption rate, dissipated mitochondrial membrane potential, and a slower rate of ATP production.	Oxygen	162-168	insulin	Homo sapiens	35-42
35039874-2	2022	Hyperbaric oxygen therapy (HBOT) has been used to successfully treat several diseases, including carbon monoxide poisoning, ischemia, infections and diabetic foot ulcer, and increases insulin sensitivity in T2DM.	Oxygen	11-17	insulin	Homo sapiens	184-191
35363442-1	2022	BACKGROUND: The testis has been reported to be a naturally O2-deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1alpha) subject to degradation under normal oxygen condition in cells.	Oxygen	59-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-151
35363442-1	2022	BACKGROUND: The testis has been reported to be a naturally O2-deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1alpha) subject to degradation under normal oxygen condition in cells.	Oxygen	59-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
35363442-1	2022	BACKGROUND: The testis has been reported to be a naturally O2-deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1alpha) subject to degradation under normal oxygen condition in cells.	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-151
35363442-1	2022	BACKGROUND: The testis has been reported to be a naturally O2-deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1alpha) subject to degradation under normal oxygen condition in cells.	Oxygen	201-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
34787344-1	2022	RATIONALE: Analyses of the isotope ratios of nitrogen (15 N/14 N) and oxygen (18 O/16 O) in nitrate (NO3 - ) with the denitrifier method require relatively high sample volumes at low concentrations (<= 1 muM) to afford sufficient analyte for mass spectrometry, resulting in isotopic offsets compared to more concentrated samples of the same isotopic composition.	Oxygen	70-76	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
35415275-6	2022	Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1alpha subunit, accelerating HIF1alpha ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes.	Oxygen	302-308	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-137
35415275-10	2022	In this review, we will summarize the state of current knowledge on the role and mechanism of action of PHD2 as oxygen sensor in regulating bone metabolism.	Oxygen	112-118	egl-9 family hypoxia inducible factor 1	Homo sapiens	104-108
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-106
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	186-191
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	259-263
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	325-330
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	heme oxygenase 1	Mus musculus	345-349
35295649-7	2022	Similar to human HGF/IgG complexes, FGF2/IgG complexes protected primary human cardiac endothelial cells under simulated ischemia (1% oxygen and nutrient deprivation) for 48-72 h. Molecular modeling studies suggested that FGF2 and HGF both interact with the Fc domain of IgG.	Oxygen	134-140	fibroblast growth factor 2	Homo sapiens	36-40
35142303-1	2022	With the aid of an exonuclease-powered DNA walker, the amount of glucose oxidase immobilized on the bioanode can be facilely tailored by varying the concentration of microRNA-141, so a glucose/O2 biofuel cell is employed as a self-powered sensor for sensitive and selective detection of microRNA-141.	Oxygen	193-195	microRNA 141	Homo sapiens	166-178
35220394-3	2022	Transmission electron microscopy, proximity ligation assays for mitochondrial VDAC1 and endoplasmic reticulum IP3R, and immunoanalyses of p-DRP1 and OPA1, demonstrate that low-oxygen conditions in early 1st trimester and PE promote mitochondrial fission in pMSCs.	Oxygen	176-182	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	149-153
35220394-5	2022	Inhibition of DRP1 oligomerization with MDiVi-1 shows that low oxygen-induced mitochondrial fission is a direct consequence of DRP1 activation, likely via HIF1.	Oxygen	63-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-159
35104488-4	2022	Catalase decomposes hydrogen peroxide into water and oxygen with the release of energy.	Oxygen	53-59	catalase	Homo sapiens	0-8
35142303-1	2022	With the aid of an exonuclease-powered DNA walker, the amount of glucose oxidase immobilized on the bioanode can be facilely tailored by varying the concentration of microRNA-141, so a glucose/O2 biofuel cell is employed as a self-powered sensor for sensitive and selective detection of microRNA-141.	Oxygen	193-195	microRNA 141	Homo sapiens	287-299
35203362-7	2022	Notably, the involvement of S1P axis in Adn action was highlighted since, when SK1 and 2 were inhibited by PF543 and ABC294640 inhibitors, respectively, not only the electrophysiological changes but also the increase of oxygen consumption and of aminoacid levels induced by the hormone, were significantly inhibited.	Oxygen	220-226	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-43
35283761-4	2022	Thus, the ancestral environment of our cells, whose energy production is strictly bind to oxygen burn, may be mediated by common defenses probably linked to the ubiquitous signaling pathway mediated by Nrf2.	Oxygen	90-96	NFE2 like bZIP transcription factor 2	Homo sapiens	202-206
35080370-8	2022	Furthermore, CFp NPs generate O2 during the catalysis and exhibit a TME-responsive T1 magnetic resonance imaging contrast enhancement, which are useful for alleviating hypoxia and in vivo monitoring of tumors, respectively.	Oxygen	30-32	complement factor properdin	Homo sapiens	13-16
35204309-1	2022	SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen.	Oxygen	127-133	superoxide dismutase 1	Homo sapiens	0-4
35197552-8	2022	TNFalpha stimulation increased basal respiration, maximal respiration, and ATP production in astrocytes, as assessed by oxygen consumption rate.	Oxygen	120-126	tumor necrosis factor	Mus musculus	0-8
35137036-7	2022	Expression of S. cerevisiae GPD2, which encodes NAD+-dependent glycerol-3-phosphate dehydrogenase, and GPP1 supported increased glycerol production by oxygen-limited chemostat cultures of O. parapolymorpha.	Oxygen	151-157	glycerol-1-phosphatase RHR2	Saccharomyces cerevisiae S288C	103-107
35193955-2	2022	GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-alpha (HIF1alpha)/VEGFA (vascular endothelial growth factor A) signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1alpha inhibition.	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	253-262
34995690-0	2022	Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation.	Oxygen	59-65	epidermal growth factor receptor	Homo sapiens	82-86
35129340-0	2022	Fast and Deep Reconstruction of Coprecipitated Fe Phosphates on Nickel Foams for an Alkaline Oxygen Evolution Reaction.	Oxygen	93-99	Fas activated serine/threonine kinase	Homo sapiens	0-4
35023512-4	2022	The current drug delivery system showed the following advantageous properties: (1) The DXM inhibited the migration, invasion and angiogenesis of vein endothelial cells by suppressing the function of vascular endothelial growth factor, thus promoting the delivery of oxygen and HDTM into the tumor site.	Oxygen	266-272	vascular endothelial growth factor A	Homo sapiens	199-233
35165707-7	2022	Mechanistic studies using the Dectin-1 inhibitor, laminarin, and Dectin-1-/- mice revealed that Galectin-3 bound to and activated Dectin-1, a receptor not previously reported in platelets, to phosphorylate spleen tyrosine kinase and thus increased Ca2+ influx, protein kinase C activation, and reactive oxygen species production to regulate platelet hyperreactivity.	Oxygen	303-309	lectin, galactose binding, soluble 3	Mus musculus	96-106
34979107-9	2022	AKT activation was observed in ASCs and those generated from pancreatic and other breast cancer cells, and AKT activation inhibition in ASCs decreased glycolysis and oxygen consumption.	Oxygen	166-172	AKT serine/threonine kinase 1	Homo sapiens	107-110
35151247-10	2022	Additionally, we found that artemisinin augments the production of reactive oxygen species which further leads to the activation of proapoptotic proteins PARP1, and caspase-3, in a concentration-dependent manner thereby triggering apoptosis.	Oxygen	76-82	poly(ADP-ribose) polymerase 1	Homo sapiens	154-159
35151247-10	2022	Additionally, we found that artemisinin augments the production of reactive oxygen species which further leads to the activation of proapoptotic proteins PARP1, and caspase-3, in a concentration-dependent manner thereby triggering apoptosis.	Oxygen	76-82	caspase 3	Homo sapiens	165-174
35205167-2	2022	Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target genes in the human body.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-148
35067692-9	2022	In the following step of the catalytic mechanism, the calculated O2 addition to C18 is preferred versus the addition to C14 which also agrees with 18R-HEPE and 18S-HEPE being the main products from EPA in aspirin-acetylated COX-2.	Oxygen	65-67	Bardet-Biedl syndrome 9	Homo sapiens	80-83
35221846-5	2022	The increases in the AGE-RAGE stress would elevate the expression and production of atherogenic factors, including reactive oxygen species, nuclear factor-kappa B, cytokines, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial leukocyte adhesion molecules, monocyte chemoattractant protein-1, granulocyte-macrophage colony-stimulating factor, and growth factors.	Oxygen	124-130	renin binding protein	Homo sapiens	21-24
35140126-11	2022	Furthermore, IL-10 reduced hemoglobin-induced reactive oxygen species in HK-2 cells and collagen synthesis in mouse embryonic fibroblast cells.	Oxygen	55-61	interleukin 10	Mus musculus	13-18
35223849-8	2022	In liver cirrhosis, the enhanced Nrf2 reduces the activation of hepatic stellate cells by reducing reactive oxygen species levels to prevent liver fibrosis.	Oxygen	108-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
35138247-7	2022	Instead, we show, that the cyanobacterial PFOR is stable in the presence of oxygen in vitro and is required for optimal photomixotrophic growth under aerobic and highly reducing conditions while the PDH complex is inactivated.	Oxygen	76-82	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	199-202
35139868-6	2022	Knockdown of Coq8 in the eye resulted in degeneration of photoreceptors, progressive necrosis and increased generation of reactive oxygen species.	Oxygen	131-137	coenzyme Q8A	Homo sapiens	13-17
35115712-16	2022	Lower splanchnic oxygen saturation variability following RBC transfusion was associated with higher 8-isoprostane and I-FABP levels.	Oxygen	17-23	fatty acid binding protein 2	Homo sapiens	118-124
35113934-5	2022	Plasma concentrations of IFN-gamma, IP-10 and neopterin, and stimulated release of O2- from PMNs exhibited dose- and time-dependent increases after IFN-gamma administration.	Oxygen	83-86	interferon gamma	Homo sapiens	148-157
35113934-10	2022	IFN-gamma appears to increase non-oxygen dependent microbicidal functions of PMNs which could provide strategies to compensate for deficiencies, explain its clinical benefit for CGD patients and expand therapeutic applications of IFN-gamma to other disorders.	Oxygen	34-40	interferon gamma	Homo sapiens	0-9
35113934-10	2022	IFN-gamma appears to increase non-oxygen dependent microbicidal functions of PMNs which could provide strategies to compensate for deficiencies, explain its clinical benefit for CGD patients and expand therapeutic applications of IFN-gamma to other disorders.	Oxygen	34-40	interferon gamma	Homo sapiens	230-239
35043137-2	2022	Herein, we report a reductant-free reductive (3 + 2 + 1) annulation of beta-keto amides with CS2 enabled by the synergy of electro/copper/base using water as an innocuous anodic sacrifice with O2 as a sustainable by-product.	Oxygen	193-195	chorionic somatomammotropin hormone 2	Homo sapiens	93-96
35105354-12	2022	CONCLUSIONS: The endometrial transcriptome in late-proliferative phase showed suppressed cell proliferation in women with thin endometria and decreased expression of PBK in human endometrial stromal cells (HESCs), to which inflammation and reactive oxygen species contributed.	Oxygen	249-255	PDZ binding kinase	Homo sapiens	166-169
35108516-0	2022	Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.	Oxygen	87-93	transglutaminase 2	Homo sapiens	12-30
35177224-20	2022	Placental oxidative stress is attenuated because cyclooxygenase-2 inhibition decreases the generation of reactive oxygen species to decrease the formation of isoprostanes.	Oxygen	114-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-65
34984824-4	2022	It is widely accepted that oxygen sensing through HIF-1 signaling pathway is paramount for the acute response to changes in oxygen levels.	Oxygen	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
34984824-4	2022	It is widely accepted that oxygen sensing through HIF-1 signaling pathway is paramount for the acute response to changes in oxygen levels.	Oxygen	124-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
34984824-7	2022	Daily oscillations in oxygen levels are circadian clock controlled and can reset the clock through HIF-1.	Oxygen	22-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
34989170-4	2022	An oxygen-modulating enzyme, catalase, is efficiently conjugated to the surface of nanoparticles via the coupling reaction.	Oxygen	3-9	catalase	Mus musculus	29-37
35093886-4	2022	RESULTS: We observed an increase in O2 - production only in BCL2KO NB cells treated with cisplatin (three-fold) and CasIIIia (five-fold), whereas the production of H2O2 in BCL2KO NB cells treated with cisplatin and CasIIIia increased five-fold and three-fold, respectively.	Oxygen	36-40	BCL2 apoptosis regulator	Homo sapiens	60-64
35093886-4	2022	RESULTS: We observed an increase in O2 - production only in BCL2KO NB cells treated with cisplatin (three-fold) and CasIIIia (five-fold), whereas the production of H2O2 in BCL2KO NB cells treated with cisplatin and CasIIIia increased five-fold and three-fold, respectively.	Oxygen	36-40	BCL2 apoptosis regulator	Homo sapiens	172-176
34753800-9	2022	Endothelial dysfunction induced by downregulated RBC miR-210 involved PTP1B and reactive oxygen species.	Oxygen	89-95	microRNA 210	Mus musculus	53-60
35125733-2	2022	Superoxide dismutase (SOD) has been commonly identified as dismutase enzyme catalyzes the conversion of superoxide to hydrogen peroxide and elemental oxygen, and could serve as an important biomarker in this direction.	Oxygen	150-156	superoxide dismutase 1	Homo sapiens	0-20
35104807-6	2022	Mechanistically, they demonstrate that sortilin altered sphingolipid/ceramide homeostasis, initiating a signaling cascade that, from sphingosine-1-phosphate (S1P), leads to the augmented production of reactive oxygen species.	Oxygen	210-216	sortilin 1	Homo sapiens	39-47
35064691-6	2022	Further study revealed that the inhibition of MAT2A affected osteoclast differentiation mainly by suppressing crucial transcription factors and reactive oxygen species induced by RANKL.	Oxygen	153-159	methionine adenosyltransferase 2A	Homo sapiens	46-51
35125733-2	2022	Superoxide dismutase (SOD) has been commonly identified as dismutase enzyme catalyzes the conversion of superoxide to hydrogen peroxide and elemental oxygen, and could serve as an important biomarker in this direction.	Oxygen	150-156	superoxide dismutase 1	Homo sapiens	22-25
35228136-9	2022	RESULTS: At baseline, IL-6 was associated with the Apnea-Hypopnea Index (beta = 0.013, p = 0.03), and the Oxygen Desaturation Index (beta = 0.028, p = 0.002).	Oxygen	106-112	interleukin 6	Homo sapiens	22-26
34260721-4	2022	METHODS: Effects of pharmacological inhibition of NAMPT on cellular oxygen consumption rate, extracellular acidification, mitochondrial respiration, cell proliferation, invasion and survival were assessed through in vitro and ex vivo studies on genetically heterogeneous glioma cell lines, glioma stem-like cells (GSCs) and mouse and human ex vivo organotypic glioma slice culture models.	Oxygen	68-74	nicotinamide phosphoribosyltransferase	Mus musculus	50-55
35075486-7	2022	Ex vivo assays of oxygen consumption and transmission electron microscopy validated early and progressive mitochondrial stress and abnormalities in mitochondrial structure and function of rd1 rods.	Oxygen	18-24	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	188-191
35101076-3	2022	METHODS: The effects of TRPM7 silencing on transcriptome profile, glucose uptake, lactic acid production, extracellular acidification rate (ECAR), oxygen consumption rate (OCR), intracellular ROS and ATP levels, and NAD+/NADH ratios in ovarian cancer cells were examined.	Oxygen	147-153	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	24-29
35072776-2	2022	Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha serine/threonine-protein kinase (Akt) signaling, which gets activated under reduced oxygen content.	Oxygen	236-242	AKT serine/threonine kinase 1	Homo sapiens	185-188
35099054-7	2022	Patients requiring oxygen supplementation and/or the use of HFNOT/CPAP/BPAP had lower lymphocyte counts and higher levels of urea, C-reactive protein, D-dimer, troponin, glucose, lactate dehydrogenase (LDH) as well as higher white blood cell and neutrophil counts, The parameter that obtained the highest area under curve value in the receiver operator curve analysis for the necessary use of HFNOT/CPAP/BPAP or CPAP/BPAP was LDH activity.	Oxygen	19-25	C-reactive protein	Homo sapiens	131-149
35163535-7	2022	Primary fibroblasts extracted from Sarm1-/- mice demonstrate an increased oxygen consumption rate relative to those from wild type mice, with significantly higher basal, maximal and spare respiratory capacity.	Oxygen	74-80	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	35-40
35090498-12	2022	Continuous treatment of ADSCs at 5% O2 resulted in a remarkable decrease in HIF-1alpha expression in comparison with 20% O2.	Oxygen	36-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
35090498-12	2022	Continuous treatment of ADSCs at 5% O2 resulted in a remarkable decrease in HIF-1alpha expression in comparison with 20% O2.	Oxygen	121-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
34935807-3	2022	Herein, a novel Z-scheme heterojunction photocatalyst O-doped g-C3N4/WO3 (OCN/W) was fabricated and used for the photocatalytic degradation of tetracycline (TC) at different dissolved oxygen concentrations.	Oxygen	184-190	bone gamma-carboxyglutamate protein	Homo sapiens	74-77
35198077-7	2022	PPARdelta directly bound to the oxygen-dependent degradation domain of HIF1alpha at the ligand-dependent domain of PPARdelta.	Oxygen	32-38	peroxisome proliferator activator receptor delta	Mus musculus	0-9
35198077-7	2022	PPARdelta directly bound to the oxygen-dependent degradation domain of HIF1alpha at the ligand-dependent domain of PPARdelta.	Oxygen	32-38	peroxisome proliferator activator receptor delta	Mus musculus	115-124
35045880-15	2022	The maximum oxygen consumption rate (OCR), ATP and lipid-related genes acc, fasn, and acadm were found to be positively correlated with TFEB/ERRalpha.	Oxygen	12-18	estrogen related receptor alpha	Homo sapiens	141-149
35012986-2	2022	Previously, we showed that the activation domains of two disordered proteins, the transcription factor HIF-1alpha and its negative regulator CITED2, function as a unidirectional, allosteric molecular switch to control transcription of critical adaptive genes under conditions of oxygen deprivation.	Oxygen	279-285	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
35012986-2	2022	Previously, we showed that the activation domains of two disordered proteins, the transcription factor HIF-1alpha and its negative regulator CITED2, function as a unidirectional, allosteric molecular switch to control transcription of critical adaptive genes under conditions of oxygen deprivation.	Oxygen	279-285	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	141-147
34935807-6	2022	Furthermore, the photocatalytic performance of OCN/W-2.0 also reaches 75% even under oxygen-deficient conditions.	Oxygen	85-91	bone gamma-carboxyglutamate protein	Homo sapiens	47-50
35050069-10	2022	Interestingly, the induction of AtDIC1 and AtDIC2 is abrogated in the erfVII mutant that is devoid of plant oxygen sensing, suggesting that these genes are part of a conserved hypoxia response in Arabidopsis.	Oxygen	108-114	dicarboxylate carrier 2	Arabidopsis thaliana	43-49
35039551-2	2022	These responses are often estimated by measuring oxygen production in the light (NCP) and consumption in the dark (CR), which can then be combined to estimate GCP.	Oxygen	49-55	golgin B1	Homo sapiens	159-162
35020757-9	2022	This study suggests that while oxygen transport capacity is the main determinant of MPO regardless of sex, thigh muscle size also has a role in whole-body maximal aerobic performance in female athletes.	Oxygen	31-37	myeloperoxidase	Homo sapiens	84-87
35087620-10	2022	Consistently, mitochondrial functions, including oxygen consumption rate, ATP levels, complex I activity, mitoROS levels, and the expression of mitochondrially encoded NADH:Ubiquinone oxidoreductase core subunit 5, were significantly increased in NDUFB3-overexpressed BCPAP cells or C643 cells.	Oxygen	49-55	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	247-253
34931659-3	2022	Exposing 5 days post-fertilization (dpf) larvae to 10% dissolved O2 (DO) for 16 h only marginally reduced survival, but it decreased forebrain neural proliferation by 55%, and reduced the expression of neurod1, gfap, and mbpa, markers of determined neurons, glia, and oligodendrocytes, respectively.	Oxygen	65-67	neuronal differentiation 1	Danio rerio	202-209
35095967-6	2021	Moreover, the rise in NH4 +/NO3 - ratio significantly promoted O2 - production.	Oxygen	63-67	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
35016541-1	2022	Hypoxia-inducible factor 1-alpha (Hif-1alpha), an important transcription factor regulating cellular responses to reductions in O2, previously was shown to improve hypoxia tolerance in zebrafish (Danio rerio).	Oxygen	128-130	hypoxia inducible factor 1 subunit alpha a	Danio rerio	0-32
35016541-1	2022	Hypoxia-inducible factor 1-alpha (Hif-1alpha), an important transcription factor regulating cellular responses to reductions in O2, previously was shown to improve hypoxia tolerance in zebrafish (Danio rerio).	Oxygen	128-130	hypoxia inducible factor 1 subunit alpha a	Danio rerio	34-44
35054894-6	2022	Recent studies revealed an interaction between hypoxia-inducible factor 1 (HIF-1), a key regulator of oxygen metabolism, and elements of circadian clocks.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-73
34999917-5	2022	HIF-1alpha is a nodal regulator of hypoxia in driving the adaptive cellular responses to changes in oxygen concentrations.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
35054894-6	2022	Recent studies revealed an interaction between hypoxia-inducible factor 1 (HIF-1), a key regulator of oxygen metabolism, and elements of circadian clocks.	Oxygen	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-80
35055236-3	2022	The CO and NH3 bonding to CoTPP does not influence the Co local electronic structure, while the NO (NO2 and O2) coordination induces a Co reduction (oxidation), generating a 3d8 CoI (3d6 CoIII) magnetically silent closed-shell species.	Oxygen	108-110	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	187-192
34998404-12	2022	Upregulation of HIF-1alpha in 5-FU-resistant CRC occurred through non-oxygen-dependent mechanisms of reactive oxygen species-mediated activation of PI3K/Akt signaling and aberrant activation of beta-catenin in the nucleus.	Oxygen	70-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
35018216-0	2022	Oxygen-independent, CDK4/CDK6-dependent degradation of hypoxia-inducible factor-1alpha takes cancers" breath away.	Oxygen	0-6	cyclin dependent kinase 6	Homo sapiens	25-29
35053230-2	2022	This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreases levels of reactive oxygen species and electrophilic substances.	Oxygen	155-161	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
35018216-0	2022	Oxygen-independent, CDK4/CDK6-dependent degradation of hypoxia-inducible factor-1alpha takes cancers" breath away.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-86
34983560-6	2022	Furthermore, the GOx/CAT cascade reaction producing consecutive fluxes of oxygen spatially targets the neutral wound tissue, and accelerates the proliferation and remodeling phases of wound healing by addressing the issues of hyperglycemia, hypoxia, and excessive oxidative stress.	Oxygen	74-80	catalase	Mus musculus	21-24
34897308-1	2022	In this communication, we propose a new strategy for double-parametric biosensing and present a dual pH/O2 lifetime sensor based on the covalent conjugation of fluorescein (pH sensor) and an orthometalated iridium complex (O2 sensor) to human serum albumin (HSA).	Oxygen	104-106	albumin	Homo sapiens	243-256
34897308-1	2022	In this communication, we propose a new strategy for double-parametric biosensing and present a dual pH/O2 lifetime sensor based on the covalent conjugation of fluorescein (pH sensor) and an orthometalated iridium complex (O2 sensor) to human serum albumin (HSA).	Oxygen	223-225	albumin	Homo sapiens	243-256
34908059-5	2022	It was shown that in beta-Ca3(PO4)2-type compounds, charge balancing is not provided by the randomly distributed oxygen vacancies but only by the partial occupancy of the M4 site.	Oxygen	113-119	small nucleolar RNA, H/ACA box 3A	Homo sapiens	21-29
34969852-5	2022	Thus, Sod1 senses O2 via O2  - to balance glycolytic and oxPPP flux, through control of GAPDH activity, for adaptation to life in air.	Oxygen	25-27	superoxide dismutase 1	Homo sapiens	6-10
34969852-0	2022	Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome.	Oxygen	16-22	superoxide dismutase 1	Homo sapiens	0-4
34969852-5	2022	Thus, Sod1 senses O2 via O2  - to balance glycolytic and oxPPP flux, through control of GAPDH activity, for adaptation to life in air.	Oxygen	25-27	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	88-93
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	116-121	superoxide dismutase 1	Homo sapiens	0-26
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	116-121	superoxide dismutase 1	Homo sapiens	28-32
34672031-1	2022	The reactivity of the molybdenum oxide cluster anion (MoO3 )5 O- , bearing an unpaired electron at a bridging oxygen atom (Ob .- ), towards methane under thermal collision conditions has been studied by mass spectrometry and density functional theory calculations.	Oxygen	110-116	cadherin 11	Homo sapiens	123-125
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	155-163	superoxide dismutase 1	Homo sapiens	0-26
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	155-163	superoxide dismutase 1	Homo sapiens	28-32
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	165-167	superoxide dismutase 1	Homo sapiens	0-26
34969852-1	2022	Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2  -) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2).	Oxygen	165-167	superoxide dismutase 1	Homo sapiens	28-32
34969852-2	2022	Using Saccharomyces cerevisiae and mammalian cells, we discovered that a major aspect of the antioxidant function of Sod1 is to integrate O2 availability to promote NADPH production.	Oxygen	138-140	superoxide dismutase 1	Homo sapiens	117-121
34969852-5	2022	Thus, Sod1 senses O2 via O2  - to balance glycolytic and oxPPP flux, through control of GAPDH activity, for adaptation to life in air.	Oxygen	18-20	superoxide dismutase 1	Homo sapiens	6-10
34969852-5	2022	Thus, Sod1 senses O2 via O2  - to balance glycolytic and oxPPP flux, through control of GAPDH activity, for adaptation to life in air.	Oxygen	18-20	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	88-93
35632987-0	2022	Neuroprotective potential of nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element signaling modulator cucurbitacin I upon glucose and oxygen deprivation/reperfusion (OGD/RP).	Oxygen	161-167	NFE2 like bZIP transcription factor 2	Rattus norvegicus	29-72
34898379-8	2022	Overall, these findings presented herein demonstrate the critical role of SMAD/ERK signaling in the regulation of AECII behavior in varying oxygen environments.	Oxygen	140-146	mitogen-activated protein kinase 1	Homo sapiens	79-82
35069450-7	2021	Results: Liraglutide increased interscapular brown adipose tissue (iBAT) oxygen consumption and enhanced beta3-adrenergic-induced oxygen consumption in iBAT and inguinal white adipose tissue (ingWAT).	Oxygen	130-136	olfactory receptor family 2 subfamily B member 4	Mus musculus	105-110
35275027-11	2022	Oxygen administration was effective with moderate quality of evidence, as well as other types of treatment (e.g. beta2, corticosteroids), but with a low level of evidence.	Oxygen	0-6	ATPase H+ transporting V0 subunit a2	Homo sapiens	113-118
35590466-9	2022	SARS-CoV-2 ORF8 protein binds the porphyrin part of hemoglobin heme at the beta1 chain, causing hemolysis and dysfunctional hemoglobin to reduce oxygen-carrying capacity.	Oxygen	145-151	BCL2 related protein A1	Homo sapiens	75-80
34975316-5	2022	Moreover, loss-of-function and gain-of-function studies have proved the critical functions of IRF7 in suppressing aerobic glycolysis of osteosarcoma cells as evidenced by glucose uptake, lactate production, extracellular acidification rate, and oxygen consumption rate.	Oxygen	245-251	interferon regulatory factor 7	Homo sapiens	94-98
34976166-9	2022	The cells cultured in 1% O2 highly expressed CD133 and CD15 and had a lower apoptosis rate.	Oxygen	25-27	fucosyltransferase 4	Mus musculus	55-59
34100452-12	2022	These data indicate that Neat1 upregulation can reduce the release of cytochrome C from the mitochondria to the cytoplasm by inhibiting the PIDD1-caspase-2 pathway, reducing the activation of caspase-3, and preventing neuronal apoptosis after oxygen and glucose deprivation, which might reduce secondary brain injury after traumatic brain injury.	Oxygen	243-249	nuclear paraspeckle assembly transcript 1 (non-protein coding)	Mus musculus	25-30
2574564-8	1989	GS and G-6-PDH specific immunological cross-reactivity remains high during the first 48 h of oxygen treatment and then declines in the interval between 48 and 54 h. During this same interval the levels of alkaline proteases which degrade oxidized proteins increase, indicating that these activities are induced or activated in response to oxidative stress and subsequently degrade the proteins which have become oxidized during the initial phase of oxygen treatment.	Oxygen	93-99	glucose-6-phosphate dehydrogenase	Rattus norvegicus	7-14
35021300-5	2022	In this sense, fragmentation of mitochondrial networks is often associated with defects in cellular energy production and increased apoptosis, leading, in turn, to excessive reactive oxygen species release, mitochondrial dysfunction, and metabolic alterations, which can ultimately contribute to beta-cell dysfunction and insulin resistance.	Oxygen	183-189	insulin	Homo sapiens	322-329
35005550-2	2022	Its expression is regulated by two different oxygen sensing systems; HIF1alpha and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia.	Oxygen	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-78
2574564-8	1989	GS and G-6-PDH specific immunological cross-reactivity remains high during the first 48 h of oxygen treatment and then declines in the interval between 48 and 54 h. During this same interval the levels of alkaline proteases which degrade oxidized proteins increase, indicating that these activities are induced or activated in response to oxidative stress and subsequently degrade the proteins which have become oxidized during the initial phase of oxygen treatment.	Oxygen	449-455	glucose-6-phosphate dehydrogenase	Rattus norvegicus	7-14
2607545-6	1989	The presence of superoxide dismutase, an oxygen free radical scavenger, prevented the release of cathepsin D and beta-N-acetylglucosaminidase from the lysosomes.	Oxygen	41-47	cathepsin D	Canis lupus familiaris	97-108
2697220-3	1989	This article reviewed the highlights for improving the key components of oxygen transport while providing examples to aid clinical application.	Oxygen	73-79	activation induced cytidine deaminase	Homo sapiens	118-121
2478233-3	1989	The CD14+/CD16+ cells can be assigned to the monocyte lineage based on typical morphology, on expression of additional monocyte-associated molecules, on the ability to form reactive oxygen intermediates and on the expression of monocyte-specific NaF-sensitive esterase.	Oxygen	182-188	CD14 molecule	Homo sapiens	4-8
2556938-6	1989	Exercise training elicited a change in muscle fiber subtype composition (+34% type IIa and -42% type IIb; P less than 0.05 and P = 0.066, respectively), a 40% increase in citrate synthase activity of skeletal muscle (P = 0.01), and a 23% rise in peak oxygen uptake (P less than 0.001).	Oxygen	251-257	citrate synthase	Homo sapiens	171-187
2588315-10	1989	These properties, together with an increased ability to unload O2, make (bis-PL)P4Hb a promising new candidate as a red cell substitute.	Oxygen	63-65	prolyl 4-hydroxylase subunit beta	Homo sapiens	80-84
2807522-4	1989	2-Chloroadenosine inhibits, in a dose-dependent fashion, O2- generation by neutrophils that have been exposed to C3b-coated particles (STZ).	Oxygen	57-59	endogenous retrovirus group K member 3	Homo sapiens	113-116
2808397-2	1989	The milli-, micro-, and nanosecond rebinding kinetics of oxygen and carbon monoxide with myoglobin (Mb) from sperm whale, horse, and dog were studied as a function of pressure up to 2 kbar by means of a high pressure laser photolysis apparatus.	Oxygen	57-63	myoglobin	Physeter catodon	89-98
2808397-2	1989	The milli-, micro-, and nanosecond rebinding kinetics of oxygen and carbon monoxide with myoglobin (Mb) from sperm whale, horse, and dog were studied as a function of pressure up to 2 kbar by means of a high pressure laser photolysis apparatus.	Oxygen	57-63	myoglobin	Physeter catodon	100-102
2573501-4	1989	This reaction is mediated by cytochrome P-450 as indicated by the requirement of NADPH, the incorporation of 18O, and inhibition by 10 mM metyrapone, 0.1 mM SKF 525-A, and CO/O2 (50/50, 80/20).	Oxygen	175-177	cytochrome P-450	Oryctolagus cuniculus	29-45
2721639-0	1989	Cycles of juvenile hormone esterase activity during the juvenile hormone-driven cycles of oxygen consumption in pupal diapause of flesh flies.	Oxygen	90-96	Juvenile hormone esterase	Drosophila melanogaster	10-35
2721639-2	1989	Levels of juvenile hormone esterase activity change systematically during the cycle, with highest activity observed at the nadir of the O2 consumption cycle.	Oxygen	136-138	Juvenile hormone esterase	Drosophila melanogaster	10-35
2630101-6	1989	The Pb2(+)-enhanced O2 consumption of the Ca2(+)-depleted cells was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) based on its calmodulin antagonistic action.	Oxygen	20-22	calmodulin 1	Rattus norvegicus	152-162
2630101-10	1989	These results indicated that Pb2+ could replace Ca2+ in the activation process(es) of the respiratory burst, suggesting a possible involvement of calmodulin in the enhancing mechanism of the O2 consumption by Pb2+.	Oxygen	191-193	calmodulin 1	Rattus norvegicus	146-156
2584778-12	1989	In experimental studies using 20 monkeys (Macaca fascicularis), continuous intraaortic infusion with O2 bubbled autologous blood increased C4a and C3a levels, while autologous blood extracorporeally contacted with nylon increased C3a levels alone.	Oxygen	101-103	complement C4-A	Macaca fascicularis	139-142
2611200-8	1989	This conformation positions one of the peripheral oxygens of the phosphate (or phosphonate) group close to the C-6 proton.	Oxygen	50-57	complement C6	Homo sapiens	111-114
2796316-4	1989	From these measurements it has proved possible to estimate the arterial oxygen tension (aPO2) of healthy adults at a relatively low sensor temperature (43 degrees C).	Oxygen	72-78	TNF receptor superfamily member 10a	Homo sapiens	88-92
2770278-1	1989	Fructose 1,6-diphosphate (FDP) has been shown to attenuate tissue injury associated with ischemia and shock by enhancing the anaerobic carbohydrate utilization and by inhibiting oxygen-free-radical generation by the neutrophils.	Oxygen	178-184	fructose-bisphosphatase 1	Rattus norvegicus	26-29
2549331-7	1989	A significant inverse correlation was observed between maximal O2 consumption by fetal BAT cells and serum insulin levels in offspring of both control and diabetic pregnancy (r = -.74; P less than .02).	Oxygen	63-65	insulin	Oryctolagus cuniculus	107-114
2469599-2	1989	Addition of porin-containing preparations (purified outer membranes or solubilized mitochondrial porin) to mitoplasts results in partial restoration of the oxygen consumption and sensitivity to carboxyatractylate (CAT).	Oxygen	156-162	voltage dependent anion channel 1	Homo sapiens	12-17
2791202-8	1989	The involvement of active oxygen in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, iodide, mannitol, formate and catalase (the inhibition was complete in the last case).	Oxygen	26-32	catalase	Bos taurus	154-162
2469599-2	1989	Addition of porin-containing preparations (purified outer membranes or solubilized mitochondrial porin) to mitoplasts results in partial restoration of the oxygen consumption and sensitivity to carboxyatractylate (CAT).	Oxygen	156-162	voltage dependent anion channel 1	Homo sapiens	97-102
2539367-6	1989	The reaction of molecular oxygen with fully reduced 2-thio-FAD XDH or 4-thio-FAD XDH resulted in 5 electron eq being released in a fast phase and one in a slow phase.	Oxygen	26-32	xanthine dehydrogenase	Gallus gallus	63-66
2539367-6	1989	The reaction of molecular oxygen with fully reduced 2-thio-FAD XDH or 4-thio-FAD XDH resulted in 5 electron eq being released in a fast phase and one in a slow phase.	Oxygen	26-32	xanthine dehydrogenase	Gallus gallus	81-84
2607653-5	1989	On the other hand, an XOD-NH2OH method which detects SOD activities based on the O2-specific oxidation reaction showed the minimum detectable amount of 2.5 ng.	Oxygen	81-83	superoxide dismutase 2	Homo sapiens	53-56
2689597-3	1989	The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond.	Oxygen	160-166	gonadotropin releasing hormone 1	Homo sapiens	93-97
2792084-6	1989	A network of seven hydrogen bonds connects oxygen atoms O-3, O-4, O-5 and O-6 of the mannoside to residues Asn14, Leu99, Tyr100, Asp208 and Arg228.	Oxygen	43-49	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	61-77
2583667-0	1989	[The oxygen dependence of the energy state of cardiac tissue--31P-NMR and optical measurement of myoglobin in perfused rat heart].	Oxygen	5-11	myoglobin	Rattus norvegicus	97-106
2583667-1	1989	The relationship between the energy state and intracellular oxygen concentration was established in the cardiac tissues, where the former could be monitored by 31PNMR and latter by optical method for myoglobin absorption.	Oxygen	60-66	myoglobin	Rattus norvegicus	200-209
2539367-8	1989	Xanthine/O2 turnover with these enzymes (and native XDH) resulted in approximately 40-50% of the xanthine reducing equivalents appearing as superoxide.	Oxygen	9-11	xanthine dehydrogenase	Gallus gallus	52-55
2548756-3	1989	The overall effect of extracellular FDP includes an increase of frequency and amplitude of contraction of perfused heart at concentration below 1 mM, and, in general, a stimulation of the oxygen consumption of the tissue.	Oxygen	188-194	fructose-bisphosphatase 1	Rattus norvegicus	36-39
2777772-0	1989	Differences in environment of FAD between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase shown by active site probe study.	Oxygen	60-62	xanthine dehydrogenase	Rattus norvegicus	92-114
2486279-3	1989	Porphyrinogenic drugs act by lowering a regulatory "free heme pool" by three different mechanisms: (a) by mechanism-based inactivation of cytochrome P-450 resulting in N-alkylprotoporphyrin formation and ferrochelatase inhibition, (b) by mechanism-based inactivation of cytochrome P-450 resulting in continuous heme destruction, (c) by enhanced generation of active oxygen species which interact with an endogenous substrate to form an inhibitor of uroporphyrinogen decarboxylase.	Oxygen	366-372	ferrochelatase	Gallus gallus	204-218
2567086-2	1989	Production of O2.- and H2O2 during the hypoxanthine/xanthine oxidase reaction occurred for at least 5 min, while lysosomal damage, indicated by the release of N-acetyl-beta-glucosaminidase, occurred within 30 s, there being no further damage to these organelles thereafter.	Oxygen	14-16	O-GlcNAcase	Rattus norvegicus	159-188
2526216-6	1989	Hence, we propose that calmodulin-dependent component of calcium fluxes in cardiac SR vesicles is modified directly by free oxygen radicals, and that free oxygen radicals can reduce steady-state calcium accumulation due to increased calcium release through a calcium efflux pathway which is inhibited by calmodulin, but not due to reduced catalytic activity of the pump.	Oxygen	124-130	calmodulin-2	Canis lupus familiaris	23-33
2480984-7	1989	Both animal and human PAAFs increase the oxygen consumption rate by RLM in state 4 dose dependently (by 65% with 50 microL to 150% with 200 microL of canine PAAF).	Oxygen	41-47	proteasomal ATPase associated factor 1	Homo sapiens	22-26
2722858-0	1989	Differences in redox and kinetic properties between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase.	Oxygen	70-72	xanthine dehydrogenase	Rattus norvegicus	102-124
2722858-1	1989	Reductive titrations of a NAD-dependent type (type-D) and an O2-dependent type (type-O) of rat liver xanthine dehydrogenase showed that only the type-D enzyme formed a pronounced stable FAD semiquinone (FADH*).	Oxygen	61-63	xanthine dehydrogenase	Rattus norvegicus	101-123
2721599-10	1989	The results are interpreted as supporting the concept that the biosynthetic pathway of pyrimidine (deoxy)nucleotides--because of two oxygen-dependent enzymes, dihydroorotate dehydrogenase and ribonucleotide reductase--is a potential transducer of environmental limitations in oxygen tension to the proliferative capacity of cells.	Oxygen	133-139	dihydroorotate dehydrogenase	Mus musculus	159-187
2721599-10	1989	The results are interpreted as supporting the concept that the biosynthetic pathway of pyrimidine (deoxy)nucleotides--because of two oxygen-dependent enzymes, dihydroorotate dehydrogenase and ribonucleotide reductase--is a potential transducer of environmental limitations in oxygen tension to the proliferative capacity of cells.	Oxygen	276-282	dihydroorotate dehydrogenase	Mus musculus	159-187
2539373-1	1989	The reactivity with dioxygen of a mammalian (sheep) ceruloplasmin, anaerobically reduced with ascorbate, was found to depend on the state of the Type 2 and Type 3 copper centers, as monitored by EPR and optical spectroscopy.	Oxygen	20-28	ceruloplasmin	Ovis aries	52-65
2538946-4	1989	Superoxide dismutase and catalase attenuated the furazolidone-mediated stimulation of oxygen consumption, indicating that the drug promoted the formation of superoxide and hydrogen peroxide.	Oxygen	86-92	catalase	Meleagris gallopavo	25-33
2659586-6	1989	When the myoglobin cDNA was expressed in Saccharomyces cerevisiae under the control of the GAL7 promoter, myoglobin was synthesized as a functionally active holoprotein which bound molecular oxygen reversibly.	Oxygen	191-197	myoglobin	Bos taurus	9-18
3144972-4	1988	Thus, the enzyme from tulip bulbs appears to be different from the cytosolic lipoxygenase from potato tubers, which exhibits non-regiospecificity in terms of O2 incorporation.	Oxygen	158-160	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	77-89
3067835-9	1988	Although insulin provided the metabolic setting for a rapid rate of glucose oxidation, this rate appeared to be diminished when the overall rate of oxygen consumption was lower during anaesthesia.	Oxygen	148-154	insulin	Oryctolagus cuniculus	9-16
2852136-7	1988	These mutations have no effect on COX5a, the other member of this small gene family which is positively regulated by heme and oxygen.	Oxygen	126-132	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	34-39
2659586-6	1989	When the myoglobin cDNA was expressed in Saccharomyces cerevisiae under the control of the GAL7 promoter, myoglobin was synthesized as a functionally active holoprotein which bound molecular oxygen reversibly.	Oxygen	191-197	myoglobin	Bos taurus	106-115
2545701-1	1989	Three Cu,Zn superoxide dismutase (SOD-1)-deficient Saccharomyces cerevisiae mutants do not grow in 100% O2 in rich medium and require Met and Lys when grown in air (Bilinski, T., Krawiec, Z., Liczmanski, A., and Litwinska, J.	Oxygen	104-106	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	34-39
2914919-0	1989	The reactivity of chicken liver xanthine dehydrogenase with molecular oxygen.	Oxygen	70-76	xanthine dehydrogenase	Gallus gallus	32-54
2848333-1	1988	The physiological significance of the enzyme indoleamine 2,3,-dioxygenase (IDO) (EC 1.13.11.17), which consumes superoxide anion (O2-), is not known.	Oxygen	130-132	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	45-73
2848333-1	1988	The physiological significance of the enzyme indoleamine 2,3,-dioxygenase (IDO) (EC 1.13.11.17), which consumes superoxide anion (O2-), is not known.	Oxygen	130-132	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	75-78
2848333-9	1988	For this reason IDO cannot act as a protective enzyme by scavenging O2- in the lung of these species.	Oxygen	68-70	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	16-19
2914919-1	1989	The reaction of 6-electron reduced chicken liver xanthine dehydrogenase (XDH) with molecular oxygen was studied using both stopped flow and steady-state turnover techniques at pH 7.8, 4 degrees C. Oxidation of fully reduced XDH proceeded via four phases, three of which were detected with the stopped flow spectrophotometer.	Oxygen	93-99	xanthine dehydrogenase	Gallus gallus	49-71
2914919-1	1989	The reaction of 6-electron reduced chicken liver xanthine dehydrogenase (XDH) with molecular oxygen was studied using both stopped flow and steady-state turnover techniques at pH 7.8, 4 degrees C. Oxidation of fully reduced XDH proceeded via four phases, three of which were detected with the stopped flow spectrophotometer.	Oxygen	93-99	xanthine dehydrogenase	Gallus gallus	73-76
2810969-7	1989	Fourth, in both groups, the plasma levels of beta TG and PF-4 were decreased 30 minutes after inspiration of the 13% oxygen gas.	Oxygen	117-123	pro-platelet basic protein	Homo sapiens	45-61
2914919-1	1989	The reaction of 6-electron reduced chicken liver xanthine dehydrogenase (XDH) with molecular oxygen was studied using both stopped flow and steady-state turnover techniques at pH 7.8, 4 degrees C. Oxidation of fully reduced XDH proceeded via four phases, three of which were detected with the stopped flow spectrophotometer.	Oxygen	93-99	xanthine dehydrogenase	Gallus gallus	224-227
2914919-3	1989	The next phase was also second order in oxygen (260 M-1 s-1), involved the loss of flavin semiquinone and yielded, on average, 1 mol of superoxide/mol of XDH oxidized.	Oxygen	40-46	xanthine dehydrogenase	Gallus gallus	154-157
2610112-0	1989	Interconversion between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase and difference in kinetic and redox properties between them.	Oxygen	42-44	xanthine dehydrogenase	Rattus norvegicus	74-96
2977133-0	1988	Oxygen exchange during the acto-subfragment-1 ATPase reaction: evidence for the two-route mechanism of the actomyosin ATPase reaction.	Oxygen	0-6	dynein axonemal heavy chain 8	Homo sapiens	46-52
2977133-0	1988	Oxygen exchange during the acto-subfragment-1 ATPase reaction: evidence for the two-route mechanism of the actomyosin ATPase reaction.	Oxygen	0-6	dynein axonemal heavy chain 8	Homo sapiens	118-124
2977133-1	1988	The oxygen exchange occurring during the acto-S-1 ATPase reaction was analyzed based on the distribution of 18O-labeled species of P1 using [gamma-18O]ATP as a substrate.	Oxygen	4-10	dynein axonemal heavy chain 8	Homo sapiens	50-56
2720154-2	1989	It was shown that in rat brain MAO"s affinity for serotonin reduced from the 5th minute of exposure to hyperbaric oxygen and went on reducing on the 15th minute.	Oxygen	114-120	monoamine oxidase A	Rattus norvegicus	31-34
2466914-3	1988	An increase in O2 consumption after f-MLP-stimulation was seen when PMN had been incubated 2-4 h with either 1000 IU/ml IFN-alpha or 100 IU/ml IFN-gamma, but this increase in O2 consumption was not observed with 1000 IU/ml IFN-beta.	Oxygen	15-17	interferon beta 1	Homo sapiens	223-231
2847035-3	1988	Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.	Oxygen	157-163	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	19-24
2518282-0	1989	Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: role of antioxidant enzymes and effect of cyclooxygenase inhibitors.	Oxygen	29-35	tumor necrosis factor-like	Rattus norvegicus	48-87
2518282-1	1989	Rats injected with interleukin-1 (10 micrograms) and tumor necrosis factor (10 micrograms) and then exposed continuously to hyperoxia (greater than 99% O2, 1 atm) survived longer, had increased lung reduced/oxidized glutathione ratios, smaller pleural effusions, less pulmonary hypertension and improved arterial blood gases.	Oxygen	152-154	tumor necrosis factor-like	Rattus norvegicus	19-74
2718449-1	1989	Investigation of opsonic activity of the serum (OAS) and indices of neutrophil phagocytosis in 35 patients with acute myeloblastic leucosis (AML) and 20 healthy subjects indicates that reduction of OAS in AML results in disturbances of the processes of reception and absorption of microorganisms by granulocytes while insufficient activation of oxygen-dependent metabolism favours disorders of bactericidal activity of neutrophils.	Oxygen	345-351	SPARC related modular calcium binding 1	Homo sapiens	198-201
2847361-5	1988	These reactions were partially inhibited by superoxide dismutase (SOD), and by SOD and catalase in the oxygen consumption assay, providing specific evidence for the involvement of O-2 in the stimulatory effect by NF.	Oxygen	103-109	catalase	Ictalurus punctatus	87-95
2719924-14	1989	The data indicate that citrate synthase stabilizes the ionized form of Ac(= S)CoA by 5 kcal/mol relative to the un-ionized form, that the ionized dithioester is on the reaction pathway, and that below pH 8.3 the slow carbon-carbon bond forming reaction is responsible for the 10(6) decrease in Vmax caused by substituting sulfur for oxygen in the thioester carbonyl.	Oxygen	333-339	citrate synthase	Homo sapiens	23-39
3221244-3	1988	Superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase provide the enzymatic defence against oxygen toxicity.	Oxygen	120-126	glutathione-disulfide reductase	Homo sapiens	60-81
2904815-2	1988	When [18O]-PEP specifically labeled in the enolic oxygen is a substrate for KDO8P synthase, the 18O is recovered in Pi.	Oxygen	50-56	prolyl endopeptidase	Homo sapiens	11-14
2540420-0	1989	Control of the Saccharomyces cerevisiae regulatory gene PET494: transcriptional repression by glucose and translational induction by oxygen.	Oxygen	133-139	Pet494p	Saccharomyces cerevisiae S288C	56-62
3191134-0	1988	Hb natal or alpha 2(minus Tyr-Arg) beta 2: a high oxygen affinity alpha chain variant with a deleted carboxy-terminus resulting from a TAC----TAA (Tyr----terminating codon) mutation in codon alpha 140.	Oxygen	50-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-41
3191134-3	1988	Hb Natal or alpha 2 (minus Tyr-Arg) beta 2 has a high affinity for oxygen without a Bohr effect and heme-heme interaction.	Oxygen	67-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	36-42
2841872-2	1988	In suspensions of IMCD cells we have previously shown that atrial natriuretic peptide (ANP) inhibits Na+ transport-dependent O2 consumption and causes an increase in cellular guanosine 3",5"-cyclic monophosphate (cGMP) content.	Oxygen	125-127	natriuretic peptides A	Oryctolagus cuniculus	59-85
2841872-2	1988	In suspensions of IMCD cells we have previously shown that atrial natriuretic peptide (ANP) inhibits Na+ transport-dependent O2 consumption and causes an increase in cellular guanosine 3",5"-cyclic monophosphate (cGMP) content.	Oxygen	125-127	natriuretic peptides A	Oryctolagus cuniculus	87-90
2540420-5	1989	PET494 was regulated by oxygen availability: expression in a respiration-competent diploid strain grown anaerobically was one-fifth the level of expression in aerobically grown cells.	Oxygen	24-30	Pet494p	Saccharomyces cerevisiae S288C	0-6
2459100-1	1988	The hyperoxia-induced increases in the activity of lung glucose-6-phosphate dehydrogenase (G-6-P) and glutathione reductase (GR) after exposure of rats to greater than 97% O2 for 6 days were accompanied by equivalent increases in the amount of the respective immunoreactive proteins.	Oxygen	172-174	glucose-6-phosphate dehydrogenase	Rattus norvegicus	56-89
2551137-0	1989	The oxygen dependence of the energy state of cardiac tissue: 31P-NMR and optical measurement of myoglobin in perfused rat heart.	Oxygen	4-10	myoglobin	Rattus norvegicus	96-105
2459100-1	1988	The hyperoxia-induced increases in the activity of lung glucose-6-phosphate dehydrogenase (G-6-P) and glutathione reductase (GR) after exposure of rats to greater than 97% O2 for 6 days were accompanied by equivalent increases in the amount of the respective immunoreactive proteins.	Oxygen	172-174	glucose-6-phosphate dehydrogenase	Rattus norvegicus	91-96
2459100-3	1988	Fetal rat lung explants cultured 4 days in 95% O2 showed increased G-6-P and GR activity and increased levels of the specific proteins 1.5-fold those of explants at 2 days of culture.	Oxygen	47-49	glucose-6-phosphate dehydrogenase	Rattus norvegicus	67-72
2837481-7	1988	N2O appears to affect oxidase activity by reducing the rate of electron transfer from cytochrome c to the O2 reaction site rather than by interfering directly with the reduction of O2 to water.	Oxygen	106-108	LOC104968582	Bos taurus	86-98
2551137-1	1989	The relationship between the energy state and intracellular oxygen concentration was established with cardiac tissue, where the former could be monitored by 31P-NMR and the latter by optical method for myoglobin absorption.	Oxygen	60-66	myoglobin	Rattus norvegicus	202-211
2753392-1	1989	The conversion of xanthine dehydrogenase to a free radical producing oxidase is an important component of oxygen-mediated tissue injury.	Oxygen	106-112	xanthine dehydrogenase	Homo sapiens	18-40
3361870-4	1988	Oxygen determinations in such an environment would aid in gaining an understanding of the role of oxygen in wound healing and the type of wound dressing that would provide an environment conducive towards wound healing.	Oxygen	0-6	activation induced cytidine deaminase	Homo sapiens	51-54
3361870-4	1988	Oxygen determinations in such an environment would aid in gaining an understanding of the role of oxygen in wound healing and the type of wound dressing that would provide an environment conducive towards wound healing.	Oxygen	98-104	activation induced cytidine deaminase	Homo sapiens	51-54
2979721-2	1988	The electron-transfer reduction of molecular oxygen yields superoxide ion (O2.-), which reacts with proton sources to form HO2..	Oxygen	45-51	heme oxygenase 2	Homo sapiens	123-126
2979721-2	1988	The electron-transfer reduction of molecular oxygen yields superoxide ion (O2.-), which reacts with proton sources to form HO2..	Oxygen	75-77	heme oxygenase 2	Homo sapiens	123-126
2979721-5	1988	+ HO2.----H2O2 + O2), which have been determined from stopped-flow spectrophotometric decay data for HO2.	Oxygen	3-5	heme oxygenase 2	Homo sapiens	101-104
2562975-2	1989	Reactions of O2- with catalase and its compound I.	Oxygen	13-15	catalase	Bos taurus	22-30
3342692-0	1988	Endothelial cell xanthine oxidase-derived toxic oxygen metabolites contribute to acute lung injury from neutrophil elastase.	Oxygen	48-54	elastase, neutrophil expressed	Homo sapiens	104-123
2835081-3	1988	By contrast, the dithionite-reduced native SOD (which contains Cu+ rather than Cu2+) exhibits only a single transition at 96 degrees C. Significantly, we find that the concentration of O2 present in native SOD samples influences the relative magnitudes of the 89 and 96 degrees C peaks.	Oxygen	185-187	superoxide dismutase [Cu-Zn]	Bos taurus	43-46
2835081-3	1988	By contrast, the dithionite-reduced native SOD (which contains Cu+ rather than Cu2+) exhibits only a single transition at 96 degrees C. Significantly, we find that the concentration of O2 present in native SOD samples influences the relative magnitudes of the 89 and 96 degrees C peaks.	Oxygen	185-187	superoxide dismutase [Cu-Zn]	Bos taurus	206-209
3127235-1	1988	Acute or chronic injection of RX 77,368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain.	Oxygen	82-88	thyrotropin releasing hormone	Rattus norvegicus	43-46
2562975-3	1989	The time-course of absorption changes of oxygen-saturated solutions of bovine-liver catalase after pulse radiolysis have been studied.	Oxygen	41-47	catalase	Bos taurus	84-92
2844541-6	1988	In addition, the decrease was counteracted by a proteinase inhibitor, the soybean trypsin inhibitor (STI), and the oxygen-free-radical scavengers superoxide dismutase (SOD) and catalase.	Oxygen	115-121	catalase-3	Glycine max	177-185
22055412-1	1988	The colour fading of sliced ham displayed in chill cabinets has been found to be caused by the combined action of light and oxygen, and can be prevented by a combination of packaging in a plastic material with low oxygen transmission rate (OTR&lt;4 cm(3)/m(2)/24h/atm), a high initial vacuum level (&gt;99%), and cold storage in the dark until residual oxygen in the packaging has been consumed (4 days for &gt;99% initial vacuum).	Oxygen	214-220	oxytocin receptor	Homo sapiens	240-243
22055412-1	1988	The colour fading of sliced ham displayed in chill cabinets has been found to be caused by the combined action of light and oxygen, and can be prevented by a combination of packaging in a plastic material with low oxygen transmission rate (OTR&lt;4 cm(3)/m(2)/24h/atm), a high initial vacuum level (&gt;99%), and cold storage in the dark until residual oxygen in the packaging has been consumed (4 days for &gt;99% initial vacuum).	Oxygen	214-220	oxytocin receptor	Homo sapiens	240-243
3118370-9	1987	Myoglobin-mediated oxygen delivery supports ATP generation by heart cells at physiological ambient oxygen pressure.	Oxygen	19-25	myoglobin	Rattus norvegicus	0-9
3118370-9	1987	Myoglobin-mediated oxygen delivery supports ATP generation by heart cells at physiological ambient oxygen pressure.	Oxygen	99-105	myoglobin	Rattus norvegicus	0-9
2856164-8	1988	The RA metabolism in rat epidermal microsomes shows the typical characteristics of a cytochrome-P-450 (P450)-dependent enzyme system, i.e. a requirement for NADPH and oxygen and inhibition by CO and SKF-525A.	Oxygen	167-173	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	103-107
2848333-12	1988	However, paraquat (10(-4) M and oxygen (100% atmosphere) were able to enhance IDO activity (5-fold) only when SOD had previously been inhibited.	Oxygen	32-38	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	78-81
3166490-8	1988	Because xanthine oxidase utilizes molecular oxygen to produce superoxide radical, ethanol-induced conversion of xanthine dehydrogenase to xanthine oxidase could contribute to the enhanced lipid peroxidation reported previously after administration of a single dose of ethanol.	Oxygen	44-50	xanthine dehydrogenase	Rattus norvegicus	112-134
3442668-5	1987	The changes in chemical shift that occur when purine riboside binds to the enzyme indicate that the hybridization of C-6 changes from sp2 to sp3 in the binary complex with formation of a new bond to oxygen or sulfur.	Oxygen	199-205	complement C6	Homo sapiens	117-120
3500140-3	1987	with RSS.-R intermediates, and repair inhibition by oxygen or copper involving RSS.-R scavenging.	Oxygen	52-58	Russell-Silver dwarfism	Homo sapiens	79-82
2823807-1	1987	Xanthine oxidase (XO) has been hypothesized to be a potential source of oxygen-derived free radicals during reperfusion of ischemic myocardium based on the fact that allopurinol, a XO-inhibitor, can reduce reperfusion injury.	Oxygen	72-78	xanthine dehydrogenase	Sus scrofa	0-16
2850806-6	1988	Pretreatment of endothelial cells with neuraminidase, heparinase or heparitinase to alter their glycocalyx composition substantially enhanced the effect of microspheres on H2O2 and O2- generation.	Oxygen	174-176	neuraminidase 1	Homo sapiens	39-52
16665719-5	1987	Since the expression of uricase has been shown to be regulated by oxygen (K Larsen, BU Jochimsen 1986 EMBO J 5: 15-19), the expression of the remaining enzymes in the purine catabolic pathway were tested in response to variations in O(2) concentration in sterile soybean callus tissue.	Oxygen	66-72	uricase-2 isozyme 1	Glycine max	24-31
16665719-5	1987	Since the expression of uricase has been shown to be regulated by oxygen (K Larsen, BU Jochimsen 1986 EMBO J 5: 15-19), the expression of the remaining enzymes in the purine catabolic pathway were tested in response to variations in O(2) concentration in sterile soybean callus tissue.	Oxygen	233-237	uricase-2 isozyme 1	Glycine max	24-31
16665719-8	1987	Hence, the expression of two enzymes involved in ureide formation, purine nucleosidase and uricase, has been demonstrated to be influenced by O(2) concentration.	Oxygen	142-146	uricase-2 isozyme 1	Glycine max	91-98
3500140-6	1987	), but also by the well-established inactivation of RSS.-R by oxygen.	Oxygen	62-68	Russell-Silver dwarfism	Homo sapiens	52-55
3500140-7	1987	There is evidence also from literature data for a correlation between oxygen enhancement and RSS.-R stability, which varies with thiol concentration, pH and thiol structure.	Oxygen	70-76	Russell-Silver dwarfism	Homo sapiens	93-96
3632722-11	1987	Our results are consistent with the following model: hypoxia converts NAD-dependent xanthine dehydrogenase (XD) into the oxygen-dependent xanthine oxidase (XO).	Oxygen	121-127	xanthine dehydrogenase	Rattus norvegicus	84-106
3195851-3	1988	By the fifth day of life, the patients who received CDP-choline required oxygen for a longer period of time, and had a lower lecithin/sphingomyelin ratio and palmitic acid percentage than those in the control group.	Oxygen	73-79	cut like homeobox 1	Homo sapiens	52-55
3593741-7	1987	Since the R state of high-spin hybrids is considered to be identical to that of low-spin hybrids, we concluded from these results that the alpha 1 beta 2 subunit boundary structure plays an important role in regulating the oxygen affinity of deoxy T state.	Oxygen	223-229	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	147-153
2825650-2	1987	In neutral solutions, desferrioxamine (Desferal) can react with the superoxide free radical, O2.- (possibly through its protonated form HO2.	Oxygen	93-95	heme oxygenase 2	Homo sapiens	136-139
3631272-0	1987	Involvement of calmodulin-calcium complex in regulation of O2 uptake in regions of the liver lobule.	Oxygen	59-61	calmodulin 1	Rattus norvegicus	15-25
2841577-2	1988	Oxygen regulation is mediated by the expression of the CYP1 gene, and the CYP1 protein interacts with both CYC1 upstream activation sequence 1 (UAS1) and CYC7 UASo.	Oxygen	0-6	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	154-158
3631272-2	1987	The purpose of this study is to evaluate the role of calmodulin in the regulation of local rates of O2 uptake.	Oxygen	100-102	calmodulin 1	Rattus norvegicus	53-63
3631272-3	1987	O2 uptake was inhibited up to 80% in a dose-dependent fashion by the calmodulin inhibitor, W-7 (I0.5 = 50-60 microM).	Oxygen	0-2	calmodulin 1	Rattus norvegicus	69-79
2841577-5	1988	Directed mutagenesis changing these GC residues to CG residues in CYC7 led to CYC1-like expression of CYC7 both in a CYP1 wild-type strain and in a strain carrying the semidominant mutation CYP1-16 which reverses the oxygen-dependent expression of the two genes.	Oxygen	217-223	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	66-70
3315762-5	1987	Patients with high maximal oxygen uptake had higher HDL2 and lower LDL cholesterol levels as well as lower total triglyceride levels.	Oxygen	27-33	junctophilin 3	Homo sapiens	52-56
2841577-5	1988	Directed mutagenesis changing these GC residues to CG residues in CYC7 led to CYC1-like expression of CYC7 both in a CYP1 wild-type strain and in a strain carrying the semidominant mutation CYP1-16 which reverses the oxygen-dependent expression of the two genes.	Oxygen	217-223	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	102-106
3618798-2	1987	Transmural anoxic wave front was determined with NADH fluorescence photography, and oxygen saturation of myoglobin and dynamic systolic wall thickening were measured with spectrophotometry of light transmitted through the left ventricular free wall.	Oxygen	84-90	myoglobin	Rattus norvegicus	105-114
2893528-4	1988	Other receptors (beta 2) may mediate coronary and peripheral vascular constriction, limiting myocardial oxygen supply and further increasing myocardial oxygen demand.	Oxygen	104-110	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-23
3618798-3	1987	In all three treatments, anoxic wave front first appeared in the subendocardium and reached the epicardial half of the myocardium in 10 s, when oxygen saturation of myoglobin decreased by 50% and tissue ATP and creatine phosphate remained at aerobic levels.	Oxygen	144-150	myoglobin	Rattus norvegicus	165-174
3663620-2	1987	The dioxygen stretch bands in infrared spectra for solutions of oxy species of human hemoglobin A and its separated subunits, human mutant hemoglobin Zurich (beta 63His to Arg), rabbit hemoglobin, lamprey hemoglobin, sperm whale myoglobin, bovine myoglobin, and a sea worm chlorocruorin are examined.	Oxygen	4-12	myoglobin	Physeter catodon	229-238
3663620-2	1987	The dioxygen stretch bands in infrared spectra for solutions of oxy species of human hemoglobin A and its separated subunits, human mutant hemoglobin Zurich (beta 63His to Arg), rabbit hemoglobin, lamprey hemoglobin, sperm whale myoglobin, bovine myoglobin, and a sea worm chlorocruorin are examined.	Oxygen	4-12	myoglobin	Bos taurus	247-256
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	99-105	glucose-6-phosphate dehydrogenase	Rattus norvegicus	242-275
3032690-3	1987	The active oxygen species also have roles in postischemic injury brought about by the conversion during ischemia of the enzyme xanthine dehydrogenase (EC 1.1.1.204) to the radical-producing xanthine oxidase (EC 1.1.3.22).	Oxygen	11-17	xanthine dehydrogenase	Homo sapiens	127-149
3590284-5	1987	The ratio HT:eta can be taken as an index of potential oxygen delivery.	Oxygen	55-61	endothelin receptor type A	Homo sapiens	13-16
3034260-1	1987	Nitrous oxide affects dioxygen utilization by both bean seed and bovine heart submitochondrial particles when either succinate or reduced cytochrome c are used as substrates.	Oxygen	22-30	LOC104968582	Bos taurus	138-150
3033206-4	1987	A different method for the preparation in situ of the (alpha 3+ beta 2+)2 valency hybrid results in a pigment with chemical and spectral properties identical with those ascribed to its synthetically reconstituted counterpart, and both bind oxygen.	Oxygen	240-246	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-73
2893528-4	1988	Other receptors (beta 2) may mediate coronary and peripheral vascular constriction, limiting myocardial oxygen supply and further increasing myocardial oxygen demand.	Oxygen	152-158	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-23
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Oxygen	44-46	endothelin receptor type A	Homo sapiens	229-232
3566278-3	1987	The rate of Mg2+ uptake can exceed 30 ng ion/min/mg protein at an efficiency of about 1 ng ion Mg2+ accumulated per ng atom O2 consumed.	Oxygen	124-126	mucin 7, secreted	Homo sapiens	12-15
3566278-3	1987	The rate of Mg2+ uptake can exceed 30 ng ion/min/mg protein at an efficiency of about 1 ng ion Mg2+ accumulated per ng atom O2 consumed.	Oxygen	124-126	mucin 7, secreted	Homo sapiens	95-98
3037351-0	1987	Elements involved in oxygen regulation of the Saccharomyces cerevisiae CYC7 gene.	Oxygen	21-27	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	71-75
3037351-4	1987	Expression of the CYC7 gene is weakly inducible by oxygen.	Oxygen	51-57	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	18-22
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Oxygen	44-46	endothelin receptor type A	Homo sapiens	240-243
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Oxygen	178-180	endothelin receptor type A	Homo sapiens	229-232
3801652-1	1987	Administration of monoamine oxidase type A inhibitor clorgyline to rats before hyperoxia prevented oxygen-induced increase in diene conjugate and Shiff"s base brain and plasma levels in hyperoxia.	Oxygen	99-105	monoamine oxidase A	Rattus norvegicus	18-42
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Oxygen	178-180	endothelin receptor type A	Homo sapiens	229-232
3108687-4	1987	Regional cerebral oxygen consumption was calculated by multiplying rCBF and cerebral oxygen extraction.	Oxygen	18-24	CCAAT/enhancer binding protein zeta	Rattus norvegicus	67-71
3364244-6	1988	By comparing the measured reaction rates of O2 and CO with the theoretical rates obtained from the numerical solutions of the partial differential equations of the diffusions of O2 and CO, the transfer coefficients of O2 and CO (eta O2 and eta CO) in the RBC boundary, including the RBC membrane and water layer around the RBC, were estimated.	Oxygen	178-180	endothelin receptor type A	Homo sapiens	229-232
3118370-0	1987	Myoglobin-mediated oxygen delivery to mitochondria of isolated cardiac myocytes.	Oxygen	19-25	myoglobin	Rattus norvegicus	0-9
3019383-5	1986	Oxygen consumption during PAH reduction by tetrahydropterin in the absence of phenylalanine but not in its presence explains the different reduction stoichiometries (tetrahydropterin:enzyme) that have been observed.	Oxygen	0-6	phenylalanine hydroxylase	Homo sapiens	26-29
3118370-1	1987	Myoglobin-mediated oxygen delivery to intracellular mitochondria is demonstrated in cardiac myocytes isolated from the hearts of mature rats.	Oxygen	19-25	myoglobin	Rattus norvegicus	0-9
3580021-1	1987	Aldehyde dehydrogenases (ALDH) isolated from livers of adult female SPF Sprague-Dawley rats were rapidly (within hours) inactivated by oxygen (7.8 ppm, from air) and simultaneous exposure to light energy (subdued daylight, 5000 lx; direct sunlight, 66,000 lx) at 22 degrees C. Oxygen withdrawal (e.g. by treatment with nitrogen) and darkness prevented the inactivation.	Oxygen	135-141	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-23
3118370-5	1987	A large part, about one-third, of the steady-state oxygen uptake is abolished by carbon monoxide blockade of myoglobin oxygenation.	Oxygen	51-57	myoglobin	Rattus norvegicus	109-118
3580021-1	1987	Aldehyde dehydrogenases (ALDH) isolated from livers of adult female SPF Sprague-Dawley rats were rapidly (within hours) inactivated by oxygen (7.8 ppm, from air) and simultaneous exposure to light energy (subdued daylight, 5000 lx; direct sunlight, 66,000 lx) at 22 degrees C. Oxygen withdrawal (e.g. by treatment with nitrogen) and darkness prevented the inactivation.	Oxygen	135-141	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	25-29
3580021-1	1987	Aldehyde dehydrogenases (ALDH) isolated from livers of adult female SPF Sprague-Dawley rats were rapidly (within hours) inactivated by oxygen (7.8 ppm, from air) and simultaneous exposure to light energy (subdued daylight, 5000 lx; direct sunlight, 66,000 lx) at 22 degrees C. Oxygen withdrawal (e.g. by treatment with nitrogen) and darkness prevented the inactivation.	Oxygen	277-283	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-23
3580021-1	1987	Aldehyde dehydrogenases (ALDH) isolated from livers of adult female SPF Sprague-Dawley rats were rapidly (within hours) inactivated by oxygen (7.8 ppm, from air) and simultaneous exposure to light energy (subdued daylight, 5000 lx; direct sunlight, 66,000 lx) at 22 degrees C. Oxygen withdrawal (e.g. by treatment with nitrogen) and darkness prevented the inactivation.	Oxygen	277-283	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	25-29
3101728-2	1987	G6PD promoted H+ production was quantified under atmospheres of N2 and O2 in frozen sections from rat mammary tissue in the presence and absence of a H+ acceptor (Total H+ and Type I H+).	Oxygen	71-73	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-4
3460064-3	1986	The pH dependence and rate-limiting second-order rate constants (kly) for oxygen transfer from H2O2 and HO2- to the iron(III) porphyrin were determined by trapping of the resultant higher-valent iron-oxo porphyrin species with 2,2"-azinodi(3-ethylbenzthiazoline)-6-sulfonate (ABTS).	Oxygen	74-80	heme oxygenase 2	Homo sapiens	104-107
3701868-4	1986	Precise determinations of the oxygen binding curves gave the unexpected finding of a dependence of co-operativity on pH with eta H rising from 2.4 at pH 6.8 to 3.0 at pH 8.	Oxygen	30-36	endothelin receptor type A	Homo sapiens	125-128
3118370-6	1987	The myoglobin-dependent component of the oxygen uptake decreases linearly with decreasing fraction of intracellular oxymyoglobin, with a slope near unity.	Oxygen	41-47	myoglobin	Rattus norvegicus	4-13
3004338-2	1986	O2- was produced by gamma irradiation of formate solutions, by the action of xanthine oxidase on hypoxanthine and O2, and by the action of ferredoxin reductase on NADPH and paraquat in the presence of O2.	Oxygen	0-2	ferredoxin reductase	Homo sapiens	139-159
3118370-7	1987	Studies using inhibitors of mitochondrial electron transport indicate that myoglobin-delivered oxygen uptake depends on electron flow through the mitochondrial electron transport chain.	Oxygen	95-101	myoglobin	Rattus norvegicus	75-84
3118370-8	1987	We conclude that cardiac mitochondria accept two additive simultaneous flows of oxygen: a flow of dissolved oxygen to cytochrome oxidase and a flow of myoglobin-bound oxygen to a mitochondrial terminus.	Oxygen	80-86	myoglobin	Rattus norvegicus	151-160
3676473-1	1987	The reversible MAO-A inhibitor moclobemide (5 mg/kg) was shown to prevent seizures in rats during exposure to toxic oxygen (6 ata).	Oxygen	116-122	monoamine oxidase A	Rattus norvegicus	15-20
2874918-2	1986	Oxygen affinities of hemoglobin (P50) from Mus musculus and Pitymys duodecimcostatus hemolysates were determined at pH 7.4 and 37 degrees C. Values obtained for delta log P50/delta pH in hemolysates from both species point out a more pronounced Bohr effect in Pitymys duodecimcostatus.	Oxygen	0-6	dynactin 2	Mus musculus	21-36
3435193-11	1987	Bovine serum albumin also improved the motility of ram spermatozoa over 8 h. After passage through Sephadex G-25 to remove any low molecular weight contaminants (less than 5 kD), BSA was still effective in stimulating the oxygen uptake of spermatozoa over 4 h. Ram blood plasma and especially ram seminal plasma were also effective after passage through the Sephadex.	Oxygen	222-228	albumin	Gallus gallus	7-20
3435193-12	1987	Human serum albumin (HSA) was as effective as BSA in stimulating the oxygen uptake of ram spermatozoa but defatting decreases its effectiveness.	Oxygen	69-75	albumin	Gallus gallus	6-19
3103674-0	1986	Molecular basis of the oxygen exchange from CO2 catalyzed by carbonic anhydrase III from bovine skeletal muscle.	Oxygen	23-29	carbonic anhydrase 3	Bos taurus	61-83
3676473-6	1987	The possibility is shown to prevent oxygen seizures not only with irreversible MAO-A inhibitors (clorgyline), but also with reversible ones (moclobemide).	Oxygen	36-42	monoamine oxidase A	Rattus norvegicus	79-84
16453663-0	1986	Expression of nodule-specific uricase in soybean callus tissue is regulated by oxygen.	Oxygen	79-85	uricase-2 isozyme 1	Glycine max	30-37
3611103-3	1987	When the reaction catalyzed by 5-oxoprolinase of Pseudomonas putida was carried out to 90% completion in H2(18)O, the residual 5-oxoproline was found to contain 18O in the amide carbonyl oxygen atom.	Oxygen	187-193	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	31-45
16453663-5	1986	The specific activity of uricase was increased by lowering the oxygen concentration, with the highest activity obtained around 4-5% oxygen.	Oxygen	63-69	uricase-2 isozyme 1	Glycine max	25-32
16453663-5	1986	The specific activity of uricase was increased by lowering the oxygen concentration, with the highest activity obtained around 4-5% oxygen.	Oxygen	132-138	uricase-2 isozyme 1	Glycine max	25-32
3103560-0	1986	Nifedipine increases oxygen saturation level of myoglobin in the rat heart during hypoxia.	Oxygen	21-27	myoglobin	Rattus norvegicus	48-57
3312952-4	1987	The RAD4 and RAD14 genes have a particular role in repair following exposure to those ethylating agents that preferentially alkylate oxygen, but not to those that preferentially ethylate nitrogen.	Oxygen	133-139	Rad4p	Saccharomyces cerevisiae S288C	4-8
3795953-2	1986	Steroid products and their analogs induce oxygen-mediated damage of microsomal P-450 activities of cultured Leydig cells, whereas testosterone acetate protects P-450 from this damage [1].	Oxygen	42-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-84
3795953-8	1986	The results suggest that steroid binding to P-450 is necessary but not sufficient to increase oxygen free-radical damage of the testicular microsomal P-450.	Oxygen	94-100	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	44-49
3007082-3	1986	In whole lungs of rats exposed to 85% oxygen there is an increase in activity (per lung or per mg lung DNA) in the antioxidant enzymes CuZn superoxide dismutase, Mn superoxide dismutase, catalase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.	Oxygen	38-44	glucose-6-phosphate dehydrogenase	Rattus norvegicus	224-257
3004564-1	1985	Occurrence of photoreduction of bovine cytochrome c oxidase was confirmed with the difference absorption spectra and oxygen consumption measurements for the enzyme irradiated with laser light at 406.7, 441.6, and 590 nm.	Oxygen	117-123	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	39-59
3488971-5	1986	Also under severely hypoxic conditions (0.01 microM oxygen in the medium) the sensitizing effect of both compounds on the induction of ssb and dsb and on cell killing was small (0-30 per cent).	Oxygen	52-58	small RNA binding exonuclease protection factor La	Homo sapiens	135-138
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	294-300	glucose-6-phosphate dehydrogenase	Rattus norvegicus	242-275
3488971-6	1986	At somewhat higher concentrations of oxygen (0.5-10 microM) however, the sensitization amounted to about 90 per cent for the induction of ssb and dsb and about 50 per cent for cell killing.	Oxygen	37-43	small RNA binding exonuclease protection factor La	Homo sapiens	138-141
3740846-3	1986	Oxygen equilibria measurements from 10 to 40 degrees C reveal that green sea turtle myoglobin has a lower oxygen affinity and lower enthalpy and entropy for oxygen-binding than the other proteins.	Oxygen	0-6	myoglobin	Chelonia mydas	84-93
3740846-3	1986	Oxygen equilibria measurements from 10 to 40 degrees C reveal that green sea turtle myoglobin has a lower oxygen affinity and lower enthalpy and entropy for oxygen-binding than the other proteins.	Oxygen	106-112	myoglobin	Chelonia mydas	84-93
3740846-3	1986	Oxygen equilibria measurements from 10 to 40 degrees C reveal that green sea turtle myoglobin has a lower oxygen affinity and lower enthalpy and entropy for oxygen-binding than the other proteins.	Oxygen	157-163	myoglobin	Chelonia mydas	84-93
3740846-4	1986	Yellowfin tuna myoglobin has the most rapid oxygen dissociation rate and the highest susceptibility to autoxidation under all conditions studied.	Oxygen	44-50	myoglobin	Physeter catodon	15-24
3007250-2	1985	Drugs which block coronary beta adrenergic receptors could exacerbate this abnormality leaving the vasoconstrictor alpha tone unopposed and/or counteracting the beta 2-mediated vasodilation elicited by the increase in myocardial oxygen demand.	Oxygen	229-235	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	161-167
2994494-4	1985	PTH (1 IU/ml) inhibited the ouabain-sensitive component of O2 consumption from 14.2 +/- 1.6 to 8.9 +/- 1.1 nmol O2 X min-1 X mg protein-1 (P less than 0.005).	Oxygen	59-61	parathyroid hormone	Oryctolagus cuniculus	0-3
2994494-4	1985	PTH (1 IU/ml) inhibited the ouabain-sensitive component of O2 consumption from 14.2 +/- 1.6 to 8.9 +/- 1.1 nmol O2 X min-1 X mg protein-1 (P less than 0.005).	Oxygen	112-114	parathyroid hormone	Oryctolagus cuniculus	0-3
2994494-6	1985	In the presence of lanthanum (5-50 microM) or verapamil (20-200 microM), PTH inhibited ouabain-sensitive O2 consumption by 21.3 +/- 3.4% (P less than 0.025) and 33.9 +/- 5.5% (P less than 0.025), respectively.	Oxygen	105-107	parathyroid hormone	Oryctolagus cuniculus	73-76
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	294-300	glucose-6-phosphate dehydrogenase	Rattus norvegicus	242-275
3742320-1	1986	A critical analysis of the arterial/alveolar oxygen tension ratio (a/APO2) is presented by rearranging the terms of the pulmonary shunt equation.	Oxygen	45-51	TNF receptor superfamily member 10a	Homo sapiens	69-73
3742320-2	1986	The influence of the shunt and inspired oxygen concentration on a/APO2 are illustrated.	Oxygen	40-46	TNF receptor superfamily member 10a	Homo sapiens	66-70
2888478-3	1987	These results are in accord with shared mechanisms of oxygen activation by TH and the more commonly studied tetrahydropterin-dependent enzyme phenylalanine hydroxylase (PAH) and strongly suggest that a peroxytetrahydropterin is the hydroxylating species generated during TH turnover.	Oxygen	54-60	phenylalanine hydroxylase	Homo sapiens	142-167
3875620-8	1985	The increase in pHi was not correlated with changes in FVECW, CBF, or CMRO2, but there was a significant correlation with the decrease in oxygen extraction fraction in the same region.	Oxygen	138-144	glucose-6-phosphate isomerase	Homo sapiens	16-19
3875620-10	1985	An alkaline shift in pHi enhances the glycolysis rate and could explain why the glucose metabolism is less affected than the oxygen metabolism in recent cerebral infarction.	Oxygen	125-131	glucose-6-phosphate isomerase	Homo sapiens	21-24
2888478-3	1987	These results are in accord with shared mechanisms of oxygen activation by TH and the more commonly studied tetrahydropterin-dependent enzyme phenylalanine hydroxylase (PAH) and strongly suggest that a peroxytetrahydropterin is the hydroxylating species generated during TH turnover.	Oxygen	54-60	phenylalanine hydroxylase	Homo sapiens	169-172
3031989-6	1987	An endotoxin-induced increase in Mn SOD could contribute to the reported protective effect of endotoxin against oxygen toxicity in these cells.	Oxygen	112-118	superoxide dismutase [Mn], mitochondrial	Bos taurus	33-39
3926762-2	1985	An abiotic system is described which chemically catalyzes the formation of less than Glu-His-Pro-NH2 (thyrotropin-releasing hormone) from less than Glu-His-Pro-amino acid in the presence of copper, ascorbate, and molecular oxygen.	Oxygen	223-229	thyrotropin releasing hormone	Homo sapiens	102-131
9939238-0	1986	Quadrupole coupling and crystal-field shielding in CaF2:Eu3+:O2- under hydrostatic pressure.	Oxygen	61-63	CCR4-NOT transcription complex subunit 8	Homo sapiens	51-55
3793732-6	1987	The equilibrium and kinetic parameters for O2 and CO binding to newly reconstituted myoglobin were observed to be identical to those of the native protein.	Oxygen	43-45	myoglobin	Physeter catodon	84-93
2869179-4	1986	Of the 11 nodules examined cytochemically, none was gamma-glutamyltransferase (gamma-GT) positive and 2 were positive to glucose-6-phosphate dehydrogenase (G-6-PD) under oxygen.	Oxygen	170-176	glucose-6-phosphate dehydrogenase	Rattus norvegicus	156-162
3999927-5	1985	MAO was assayed by measuring the rate of oxygen consumption in a small cell with a Clark electrode.	Oxygen	41-47	monoamine oxidase A	Rattus norvegicus	0-3
3028766-5	1987	Mean arterial pressure decreased significantly from 117 +/- 4.3 to 103 +/- 6.7 mmHg (p less than 0.05) in the O2 exposed group despite a threefold increase in plasma renin activity.	Oxygen	110-112	renin	Rattus norvegicus	166-171
2982386-4	1985	The phenolate anion could be further oxidized by molecular oxygen to generate the C-6, C-11 (B-ring) semiquinone as detected by a weak electron paramagnetic resonance spectrometry signal.	Oxygen	59-65	complement C6	Homo sapiens	82-85
3961299-1	1986	The role of myoglobin in facilitating O2 diffusion for oxidative energy production was investigated at high (0.9 mM) and low (0.1 mM) O2 tensions in the Langendorff-perfused rat heart.	Oxygen	38-40	myoglobin	Rattus norvegicus	12-21
3961299-5	1986	However, at 0.9 mM O2, myoglobin inactivation did not limit oxidative energy metabolism.	Oxygen	19-21	myoglobin	Rattus norvegicus	23-32
3961299-6	1986	It is concluded that facilitation of O2 diffusion by cardiac myoglobin plays a significant role in O2 delivery to the mitochondria at low O2 tensions.	Oxygen	37-39	myoglobin	Rattus norvegicus	61-70
3961299-6	1986	It is concluded that facilitation of O2 diffusion by cardiac myoglobin plays a significant role in O2 delivery to the mitochondria at low O2 tensions.	Oxygen	99-101	myoglobin	Rattus norvegicus	61-70
3508430-3	1987	Addition of superoxide dismutase or catalase clearly suppressed the ethanol-induced release of GPT and SDH, suggesting that .O2- and H2O2 are involved in this process.	Oxygen	125-127	sorbitol dehydrogenase	Rattus norvegicus	103-106
3961299-6	1986	It is concluded that facilitation of O2 diffusion by cardiac myoglobin plays a significant role in O2 delivery to the mitochondria at low O2 tensions.	Oxygen	99-101	myoglobin	Rattus norvegicus	61-70
3006748-8	1986	Studies with scavengers of partially reduced dioxygen show that catalase decreases the rate of CO oxygenation.	Oxygen	45-53	catalase	Bos taurus	64-72
3156149-6	1985	Plasmin blocked the thrombin-induced release of [3H]arachidonic acid from platelet membrane phospholipids and the thrombin-induced platelet oxygen burst.	Oxygen	140-146	plasminogen	Homo sapiens	0-7
3966801-0	1985	Nanosecond motions of the single tryptophan residues in apolipoproteins C-I and C-II: a study by oxygen quenching and fluorescence depolarization.	Oxygen	97-103	apolipoprotein C1	Homo sapiens	56-75
3966801-1	1985	Rotational freedom of the single tryptophan residue in human plasma apolipoproteins C-I (apo C-I) and C-II (apo C-II) was investigated by oxygen quenching and lifetime-resolved anisotropies.	Oxygen	138-144	apolipoprotein C1	Homo sapiens	68-87
3966801-1	1985	Rotational freedom of the single tryptophan residue in human plasma apolipoproteins C-I (apo C-I) and C-II (apo C-II) was investigated by oxygen quenching and lifetime-resolved anisotropies.	Oxygen	138-144	apolipoprotein C1	Homo sapiens	89-96
3966801-2	1985	The tryptophan in both apo C-I and C-II was highly accessible to oxygen quenching.	Oxygen	65-71	apolipoprotein C1	Homo sapiens	23-30
3878994-1	1985	Using positron emission tomography and the 15O continuous inhalation technique, we have measured the regional cerebral blood flow (rCBF) oxygen extraction fraction (rOEF) and oxygen consumption (rCMRO2) of non-infarcted tissue in six patients with either tight stenosis (N = 3) or occlusion (N = 3) of the trunk of the middle cerebral artery (MCA); these arterial lesions were shown to be persistent on late and/or repeated angiograms.	Oxygen	137-143	CCAAT/enhancer binding protein zeta	Rattus norvegicus	131-135
3941087-12	1986	Species of CBP with faster or slower electrophoretic mobilities could be generated by treatment of the protein either with O2 in the presence of a catalyst or with dithiothreitol.	Oxygen	123-125	eukaryotic translation initiation factor 4E	Homo sapiens	11-14
3799293-0	1986	Oxygen transport to tissue VIII.	Oxygen	0-6	cytochrome c oxidase subunit 8A	Homo sapiens	27-31
3303017-3	1987	Anaemia of infected animals developed on day 4 after inoculation and oxygen affinity of whole blood, measured as P50 act pH, increased simultaneously.	Oxygen	69-75	dynactin 2	Mus musculus	113-116
4092051-5	1985	Our previously proposed detailed mechanism for alkyl-DHAP synthase predicted that the fatty acid should retain both of the carboxyl ester oxygens upon cleavage.	Oxygen	138-145	alkylglycerone phosphate synthase	Homo sapiens	47-66
4074780-3	1985	It was shown that in uncoupled reactions cytochrome P-450, besides O2- generation catalyzes direct two- and four-electron reduction of O2 to produce H2O2 and water, respectively.	Oxygen	67-69	cytochrome P-450	Oryctolagus cuniculus	41-57
4074780-3	1985	It was shown that in uncoupled reactions cytochrome P-450, besides O2- generation catalyzes direct two- and four-electron reduction of O2 to produce H2O2 and water, respectively.	Oxygen	135-137	cytochrome P-450	Oryctolagus cuniculus	41-57
4074780-8	1985	The experimental results suggest that the ratio of reactions of one- and two-electron reduction of O2 is controlled by the ratio of rates of one- and two-electron reduction of cytochrome P-450.	Oxygen	99-101	cytochrome P-450	Oryctolagus cuniculus	176-192
6475110-7	1984	As can be taken from measurements described in this paper, the main contribution to this deterioraction comes from the age-dependent diminution of the cardiac minute or stroke volume, respectively, since eta--the percent exhaustion of the oxygen-binding capacity of blood--increases even with progressing age, as was found by us.	Oxygen	239-245	endothelin receptor type A	Homo sapiens	204-207
6475110-8	1984	Numerous determinations of the arterial and venous pO2 resting levels have shown that the values of eta can almost be doubled easily by the procedures of the Oxygen Multistep Therapy, whereby--as a rule--the age-dependent decrease of the cardiac output is overcompensated.	Oxygen	158-164	endothelin receptor type A	Homo sapiens	100-103
6495818-0	1984	Studies on the possible mechanism of inactivation of phenylalanine hydroxylase by destructive oxygen species.	Oxygen	94-100	phenylalanine hydroxylase	Homo sapiens	53-78
6495818-6	1984	These findings suggest that the termination of phenylalanine hydroxylation in the absence of hydrogen peroxide removing reactions is probably due to destructive oxygen species generated at the active site iron of phenylalanine hydroxylase in the presence of H2O2 and the tetrahydropterin cofactor.	Oxygen	161-167	phenylalanine hydroxylase	Homo sapiens	213-238
3615491-10	1987	O2 affinity was partially corrected in the HN2 treated HbSS red cells.	Oxygen	0-2	MT-RNR2 like 2 (pseudogene)	Homo sapiens	43-46
6742948-2	1984	These erythrocytes with increased HbA1 had decreased oxygen dissociation ability, resulting in decreased function.	Oxygen	53-59	hemoglobin subunit alpha 1	Homo sapiens	34-38
3931680-1	1985	Biphasic responses of amino[14C]pyrine accumulation and oxygen consumption were registered by gastrin stimulation in dispersed parietal cells from guinea pig gastric mucosa, and this was mimicked with the calcium ionophore A23187.	Oxygen	56-62	gastrin	Cavia porcellus	94-101
3615491-12	1987	Among the added advantages of HN2 for extra-corporeal use is its rapid reaction rate, the lack of significant change of the O2 equilibrium at the concentration tested and the fact that the unreacted compound can be readily detected and neutralized.	Oxygen	124-126	MT-RNR2 like 2 (pseudogene)	Homo sapiens	30-33
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	34-40	hematopoietically expressed homeobox	Homo sapiens	79-82
3103560-2	1986	Oxygen saturation level of myocardial myoglobin was measured continuously according to an optical method, by which the intracellular oxygen level in the myocardial cells can be monitored continuously.	Oxygen	0-6	myoglobin	Rattus norvegicus	38-47
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	34-40	hematopoietically expressed homeobox	Homo sapiens	205-208
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	34-40	hematopoietically expressed homeobox	Homo sapiens	205-208
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	292-298	hematopoietically expressed homeobox	Homo sapiens	79-82
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	292-298	hematopoietically expressed homeobox	Homo sapiens	205-208
3004685-6	1985	All of the 38 stable oxygen sensitive mutants obtained had very low or completely absent catalatic activity and catalase protein.	Oxygen	21-27	catalase	Bos taurus	112-120
3103560-2	1986	Oxygen saturation level of myocardial myoglobin was measured continuously according to an optical method, by which the intracellular oxygen level in the myocardial cells can be monitored continuously.	Oxygen	133-139	myoglobin	Rattus norvegicus	38-47
3005544-2	1985	Oxygen radical scavenging activity of PR-B, an anti-inflammatory protein of Persicae semen].	Oxygen	0-6	RB transcriptional corepressor 1	Homo sapiens	38-42
4008494-0	1985	Resonance Raman studies of CO and O2 binding to elephant myoglobin (distal His(E7)----Gln).	Oxygen	34-36	myoglobin	Physeter catodon	57-66
4008494-1	1985	Carbon monoxide and dioxygen were employed as resonance Raman-visible ligands for probing the nature of the heme-binding site in elephant myoglobin, which has glutamine in the distal position (E7) instead of the usual histidine.	Oxygen	20-28	myoglobin	Physeter catodon	138-147
6722936-2	1984	Information on the origins of the oxygen atoms in four major metabolites of NO-HEX was obtained by metabolizing this compound in an 18O2 atmosphere using microsomes and cytosol, beta- and gamma-Hydroxy-NO-HEX are formed as a result of the insertion of a hydroxyl group derived from molecular oxygen into NO-HEX.	Oxygen	292-298	hematopoietically expressed homeobox	Homo sapiens	205-208
6724191-1	1984	The antioxidant enzyme superoxide dismutase (SOD) found in the cytosol of eucaryotic cells and the plasma protein ceruloplasmin are copper containing proteins though to be important in providing protection from oxygen toxicity.	Oxygen	211-217	ceruloplasmin	Rattus norvegicus	114-127
6701097-1	1984	The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer (pH 6.8) at 37 degrees C. Addition of hydrogen peroxide (H2O2) remarkably enhanced this hydroxylation.	Oxygen	95-101	homeobox C8	Homo sapiens	4-7
6701097-1	1984	The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer (pH 6.8) at 37 degrees C. Addition of hydrogen peroxide (H2O2) remarkably enhanced this hydroxylation.	Oxygen	103-105	homeobox C8	Homo sapiens	4-7
3103560-6	1986	Hypoxia increased coronary flow by about 25%, decreased oxygen saturation level of myoglobin by 23.1-35.7%, without a marked change in left ventricular pressure.	Oxygen	56-62	myoglobin	Rattus norvegicus	83-92
4014439-9	1985	Following an initial anoxic reperfusion, oxygen caused additional CK and Myo release and produced an increase in the percent of cells with contraction bands, compared with that with oxygen alone.	Oxygen	41-47	myoglobin	Rattus norvegicus	73-76
3103560-8	1986	Nifedipine at the concentration of 0.1 microgram/ml also increased the oxygen saturation level of myocardial myoglobin slightly, but at the concentration of 10 micrograms/ml it decreased.	Oxygen	71-77	myoglobin	Rattus norvegicus	109-118
3103560-10	1986	It is concluded that nifedipine as well as nitroglycerin can increase the oxygen saturation level of myocardial myoglobin during hypoxia, suggesting that both drugs may increase the intracellular oxygen tension in the hypoxic heart.	Oxygen	74-80	myoglobin	Rattus norvegicus	112-121
3103560-10	1986	It is concluded that nifedipine as well as nitroglycerin can increase the oxygen saturation level of myocardial myoglobin during hypoxia, suggesting that both drugs may increase the intracellular oxygen tension in the hypoxic heart.	Oxygen	196-202	myoglobin	Rattus norvegicus	112-121
3800887-0	1986	Oxidation of reduced Cu,Zn superoxide dismutase by molecular oxygen.	Oxygen	61-67	superoxide dismutase [Cu-Zn]	Bos taurus	21-47
3922385-11	1985	Prompt recognition, descent, and administration of oxygen constitute the major therapies for severe ARI.	Oxygen	51-57	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	100-103
3800887-2	1986	The rate of oxidation of reduced bovine Cu,Zn superoxide dismutase [ECu(I)] by molecular O2 was studied by magnetic-resonance techniques and was found to be low under physiological conditions.	Oxygen	89-91	superoxide dismutase [Cu-Zn]	Bos taurus	40-66
4026967-6	1985	The increases in chemiluminescence and Mn-SOD activity suggests that the generation of a large amount of activated oxygen is associated with the pathogenesis and progression of alcoholic liver injury in humans.	Oxygen	115-121	superoxide dismutase 2	Homo sapiens	39-45
3013683-4	1986	Using nigericin/K+ to clamp pHi we demonstrated that the acidification accounts for the inhibition of O2 uptake.	Oxygen	102-104	glucose-6-phosphate isomerase	Homo sapiens	28-31
4030280-0	1985	Use of oxygen driven nebulizer delivery systems for beta-2 agonists in chronic bronchitis.	Oxygen	7-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	52-58
3998807-4	1985	In normal man, changes in the regional cortical metabolic rate of O2 leads to proportional changes in rCBF.	Oxygen	66-68	CCAAT/enhancer binding protein zeta	Rattus norvegicus	102-106
3014700-5	1986	After 63 h in 100% O2 and 24 h in air, Cyt was present in the basal lamina of all instilled alveoli.	Oxygen	19-21	cytochrome c	Oryctolagus cuniculus	39-42
3911705-4	1985	Apart from effects on brain circulation secondary to the effects of HDC on brain edema, direct effects of HDC on cerebral blood flow and oxygen uptake have been studied mainly in experimental endotoxic shock.	Oxygen	137-143	histidine decarboxylase	Homo sapiens	106-109
3911705-7	1985	Pretreatment with HDC prevents the effects of endotoxin on cerebral blood flow and oxygen uptake.	Oxygen	83-89	histidine decarboxylase	Homo sapiens	18-21
3911705-8	1985	When HDC was given after an intravenous endotoxin injection blood flow was unaffected but the increased cerebral oxygen uptake was reduced transiently.	Oxygen	113-119	histidine decarboxylase	Homo sapiens	5-8
3966800-2	1985	Measurements of oxygen consumption revealed that the electron transport system was capable of reoxidizing ALDH-generated NADH much faster than it was produced and hence was not rate-limiting for aldehyde metabolism.	Oxygen	16-22	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	106-110
3014700-8	1986	In contrast, after 48 h in O2 followed by 24 h of breathing air, cytochrome C was totally restricted in the alveolar space.	Oxygen	27-29	cytochrome c	Oryctolagus cuniculus	65-77
2425164-8	1986	During maximal pacing rate at D3, the myocardial oxygen consumption was 14% above control level (N.S.).	Oxygen	49-55	dynein cytoplasmic 2 heavy chain 1	Homo sapiens	27-32
3917990-1	1985	Whereas it is widely believed that animals native to high altitude show lower O2 partial pressures at 50% hemoglobin saturation (P50) than do related animals native to low altitude, that "fact" has not been well documented.	Oxygen	78-80	dynactin 2	Mus musculus	129-132
6527384-2	1984	Oxygen equilibrium studies showed that stripped Hb Wayne Asn and Hb Wayne Asp possessed high oxygen affinity (P 1/2 = 0.60 and 0.23 mmHg at pH 7, respectively), were non-co-operative and have a markedly reduced Bohr effect (-delta log P 1/2/pH (7 to 8) = 0.34 and 0.10, respectively).	Oxygen	93-99	catenin delta 1	Homo sapiens	110-119
3727040-2	1986	A preliminary injection of clorgyline (a monoamine oxidase type A inhibitor) before hyperoxic exposure leads to a significant removal of oxygen seizures and prevents changes in the cerebral spermidine and histamine content observed in the unprotected animals.	Oxygen	137-143	monoamine oxidase A	Rattus norvegicus	41-65
6084730-0	1984	Effects of Ca2+ and calmodulin antagonists on the oxygen uptake induced by acetylcholine or substance P in rat submandibular gland slices.	Oxygen	50-56	calmodulin 1	Rattus norvegicus	20-30
3944110-7	1986	The properties of purified PAM-A and PAM-B were very similar to those of amidation activity in crude extracts: activity was reduced upon removal of molecular oxygen; activity was stimulated by the addition of CuSO4 and eliminated by the addition of diethyldithiocarbamate; activity was stimulated by the addition of ascorbate, with optimal levels of ascorbate increasing as the concentration of peptide substrate was increased.	Oxygen	158-164	peptidylglycine alpha-amidating monooxygenase	Bos taurus	27-30
6088632-0	1984	Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G.	Oxygen	20-26	elastase, neutrophil expressed	Homo sapiens	115-134
6332319-3	1984	Rats exposed either to continuous 85% oxygen for 7 days or to intermittent hyperbaric oxygen for up to 19 days developed not only enhanced lung antioxidant enzymes but also increased levels of serum ceruloplasmin.	Oxygen	38-44	ceruloplasmin	Rattus norvegicus	199-212
6332319-3	1984	Rats exposed either to continuous 85% oxygen for 7 days or to intermittent hyperbaric oxygen for up to 19 days developed not only enhanced lung antioxidant enzymes but also increased levels of serum ceruloplasmin.	Oxygen	86-92	ceruloplasmin	Rattus norvegicus	199-212
6332319-5	1984	Induction of ceruloplasmin may account for some of the anti-inflammatory activities of elevated oxygen tensions.	Oxygen	96-102	ceruloplasmin	Rattus norvegicus	13-26
3944110-7	1986	The properties of purified PAM-A and PAM-B were very similar to those of amidation activity in crude extracts: activity was reduced upon removal of molecular oxygen; activity was stimulated by the addition of CuSO4 and eliminated by the addition of diethyldithiocarbamate; activity was stimulated by the addition of ascorbate, with optimal levels of ascorbate increasing as the concentration of peptide substrate was increased.	Oxygen	158-164	peptidylglycine alpha-amidating monooxygenase	Bos taurus	37-40
6090312-7	1984	Other enzymes, the lipoxygenases, may instead introduce oxygen at C-5, C-8, C-9, C-12 or C-15: further conversions from, for example, the initially formed 5- or 15-hydroperoxy acids may lead to the leukotrienes.	Oxygen	22-28	homeobox C8	Homo sapiens	71-74
3006800-1	1986	Sheep haptoglobin (HpC) binding hemoglobin increases the stability of the latter to acid denaturation and oxidation by atmospheric O2.	Oxygen	131-133	haptoglobin	Ovis aries	6-17
6204963-5	1984	When mice were exposed to 75% O2, the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced.	Oxygen	30-32	glutathione reductase	Mus musculus	111-132
6204963-5	1984	When mice were exposed to 75% O2, the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced.	Oxygen	183-189	glutathione reductase	Mus musculus	111-132
4063376-0	1985	Assignment of heme and distal amino acid resonances in the 1H-NMR spectra of the carbon monoxide and oxygen complexes of sperm whale myoglobin.	Oxygen	101-107	myoglobin	Physeter catodon	133-142
6328158-0	1984	Thyrotropin-releasing hormone (TRH) and its analog (DN-1417): interaction with pentobarbital in oxygen consumption and cyclic AMP formation of rat cerebral cortex slices.	Oxygen	96-102	thyrotropin releasing hormone	Rattus norvegicus	0-29
6328158-0	1984	Thyrotropin-releasing hormone (TRH) and its analog (DN-1417): interaction with pentobarbital in oxygen consumption and cyclic AMP formation of rat cerebral cortex slices.	Oxygen	96-102	thyrotropin releasing hormone	Rattus norvegicus	31-34
4063376-1	1985	Assignments of resonances of the heme and distal amino acid protons in spectra of the CO and O2 complexes of sperm whale myoglobin are reported.	Oxygen	93-95	myoglobin	Physeter catodon	121-130
3877483-7	1985	There was a highly significant correlation between the alveolar-arterial oxygen tension difference and the neutrophil elastase concentration in BAL from the patients with ARDS.	Oxygen	73-79	elastase, neutrophil expressed	Homo sapiens	107-126
6378184-3	1984	Subsequent analysis by combined g.l.c.-mass spectrometry demonstrated that the oxygen isotope, is incorporated into the B29 carbonyl group of the insulin ester product.	Oxygen	79-85	insulin	Sus scrofa	146-153
6143758-12	1984	Guanylate cyclase activation by phenylhydrazine resulted from an O2-dependent reaction between phenylhydrazine and hemoproteins to generate stable iron-phenyl hemoprotein complexes.	Oxygen	65-67	guanylate cyclase	Bos taurus	0-17
4034284-7	1985	The activity of antioxidant enzymes (glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione reductase) was increased in lungs of newborn rats exposed to 100% oxygen either at birth or 2 days of age.	Oxygen	174-180	glucose-6-phosphate dehydrogenase	Rattus norvegicus	37-70
6323471-2	1984	We have studied the time course of the absorption of bovine liver catalase after pulse radiolysis with oxygen saturation in the presence and absence of superoxide dismutase.	Oxygen	103-109	catalase	Bos taurus	66-74
4040516-1	1985	The association of dioxygen and carbon monoxide to soybean leghemoglobin (Lb) has been studied by laser flash photolysis at temperatures from 10 to 320 K and times from 50 ns to 100 s. Infrared spectra of the bound and the photodissociated state were investigated between 10 and 20 K. The general features of the binding process in leghemoglobin are similar to the ones found in myoglobin.	Oxygen	19-27	myoglobin	Physeter catodon	379-388
2861789-5	1985	We have proposed that the mixed-function oxidation system (the cytochrome P-450 system) produces Fe(II) and H2O2 which react at the metal binding site on the glutamine synthetase to generate an activated oxygen species which oxidizes a nearby susceptible histidine.	Oxygen	204-210	cytochrome P-450	Oryctolagus cuniculus	63-79
6585203-3	1984	We report here that the process of net nitroreduction of 5-nitro-2-furaldehyde semicarbazone (nitrofurazone) by rat liver xanthine dehydrogenase was considerably less sensitive to inhibition by oxygen than was nitroreduction catalyzed by rat liver or milk xanthine oxidase.	Oxygen	194-200	xanthine dehydrogenase	Rattus norvegicus	122-144
2408615-1	1985	We report the full structure of two elliptinium diribonucleosides monophosphate adducts: the oxidized form of this antitumor agent alkylates very selectively the pX ribose of ApX (X = G or U) leading to a spiro derivative, where the C10 atom of ellipticine skeleton is linked to both sugar oxygen atoms 2" and 3".	Oxygen	290-296	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	175-178
6653501-4	1983	After 7 days in 85% oxygen (0 days in air) activities of G6PD, GR, and GP, were elevated above control values by 189%, 32%, and 126%, respectively, and NPSH was 146% higher.	Oxygen	20-26	glucose-6-phosphate dehydrogenase	Rattus norvegicus	57-61
6097242-2	1984	Solutions prepared in the presence of atmospheric oxygen at pH = 12 exhibited a typical semiquinone signal preceded by a short-lived signal attributed to perhydroxyl radical, HO2.	Oxygen	50-56	heme oxygenase 2	Homo sapiens	175-178
6511912-3	1984	and CCl(3)00.. Oxygen strongly inhibits the hepatic cytochrome P-450-mediated formation of CCl3.	Oxygen	15-21	C-C motif chemokine ligand 3	Rattus norvegicus	91-95
6511912-14	1984	Increases in O2 tension caused a fall in CHCl3 production, which indicated that it decreased CCl3.. GSH had no significant effect on CHCl3 production at any O2 tension.	Oxygen	13-15	C-C motif chemokine ligand 3	Rattus norvegicus	93-97
6511912-18	1984	They suggest that hyperbaric O2 might decrease free radical formation in the liver in vivo and promote formation of CCl(3)00. from CCl3..	Oxygen	29-31	C-C motif chemokine ligand 3	Rattus norvegicus	131-135
6511912-23	1984	This strongly suggests that hyperbaric O2 is decreasing free radical formation from CCl4 and/or promoting the formation of CCl(3)00. from CCl3..	Oxygen	39-41	C-C motif chemokine ligand 3	Rattus norvegicus	138-142
6093658-0	1984	The effect of oxygen tension on the in vitro production and release of angiotensin-converting enzyme by bovine pulmonary artery endothelial cells.	Oxygen	14-20	angiotensin I converting enzyme	Bos taurus	71-100
6093658-2	1984	Exposure to hypoxia (3% O2) for 24 or 48 h resulted in increased cell angiotensin-converting enzyme (ACE) activity compared with cells exposed to normoxia (20% O2), but there was no change in cell supernatant ACE activity.	Oxygen	24-26	angiotensin I converting enzyme	Bos taurus	70-99
6093658-2	1984	Exposure to hypoxia (3% O2) for 24 or 48 h resulted in increased cell angiotensin-converting enzyme (ACE) activity compared with cells exposed to normoxia (20% O2), but there was no change in cell supernatant ACE activity.	Oxygen	24-26	angiotensin I converting enzyme	Bos taurus	101-104
6093658-4	1984	The exposure of cells to hyperoxia (80% O2) for 24 or 48 h caused decreased cell and culture supernatant ACE activity compared with cells exposed to normoxia, but the effects of hyperoxia may be attributed to reduced cell growth rates.	Oxygen	40-42	angiotensin I converting enzyme	Bos taurus	105-108
6093658-5	1984	Cell exposed to 7% O2 and 20% O2 had similar ACE activities.	Oxygen	19-21	angiotensin I converting enzyme	Bos taurus	45-48
6093658-5	1984	Cell exposed to 7% O2 and 20% O2 had similar ACE activities.	Oxygen	30-32	angiotensin I converting enzyme	Bos taurus	45-48
6093658-7	1984	Our studies show that oxygen tension affects endothelial cell ACE activity.	Oxygen	22-28	angiotensin I converting enzyme	Bos taurus	62-65
6510607-5	1984	The prolonged inhibition of glutathione reductase by BCNU suggested this drug might enhance pulmonary oxygen toxicity by diminishing the lung"s antioxidant capacity.	Oxygen	102-108	glutathione reductase	Mus musculus	28-49
6518192-4	1984	In experiments with membrane-bound and partially purified MAO, the Km and V values were shown to increase non-competitively with a rise in O2 concentration.	Oxygen	139-141	monoamine oxidase A	Rattus norvegicus	58-61
6518192-5	1984	In contrast with intact mitochondria, the use of partially purified MAO preparations led to a loss of the enzyme sensitivity to O2 depending on the nature of the amine.	Oxygen	128-130	monoamine oxidase A	Rattus norvegicus	68-71
6742136-10	1984	PTH increased work done and oxygen consumption by the gland but arterial phosphate enrichment did not.	Oxygen	28-34	parathyroid hormone	Ovis aries	0-3
6382955-1	1984	Human and other mammalian forms of ATase, including the Chinese hamster enzyme, are oxygen-sensitive enzymes and human ATase, like the enzyme from B. subtilis, is an iron-sulfur protein.	Oxygen	84-90	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	35-40
6382955-2	1984	When protein synthesis is inhibited in cultured Chinese hamster cells, ATase activity is lost in an oxygen-dependent reaction.	Oxygen	100-106	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	71-76
6319532-5	1984	Vigorous consumption of oxygen was also stimulated by the ingestion of E(IgG) but not by ingestion of E(IgM)C or GE.	Oxygen	24-30	immunoglobulin heavy chain (V7183 family)	Mus musculus	71-77
6382955-3	1984	The hypothesis is developed that the sensitivity of ATase to oxygen inactivation controls the rate of degradation of this enzyme in mammalian cells, similar to the mechanism which has been demonstrated for regulation of ATase degradation in B. subtilis.	Oxygen	61-67	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	52-57
6382955-3	1984	The hypothesis is developed that the sensitivity of ATase to oxygen inactivation controls the rate of degradation of this enzyme in mammalian cells, similar to the mechanism which has been demonstrated for regulation of ATase degradation in B. subtilis.	Oxygen	61-67	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	220-225
6089818-3	1984	Oxygen is able to restore about 50% of the Type 1 copper absorption in ascorbate-reduced ceruloplasmin, while the other half is recovered after addition of H2O2.	Oxygen	0-6	ceruloplasmin	Ovis aries	89-102
6441605-0	1984	[Monoamine oxidase and diamine oxidase activity of the tissues of rats in the convulsive phase of oxygen poisoning].	Oxygen	98-104	amine oxidase, copper containing 1	Rattus norvegicus	23-38
6316150-1	1983	Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper.	Oxygen	137-143	superoxide dismutase 2	Homo sapiens	35-38
6641945-4	1983	The results indicate that myoglobin oxidation may be an early sign of oxidative injury and may limit myocardial function by elimination of this short-term O2 reserve.	Oxygen	155-157	myoglobin	Rattus norvegicus	26-35
6639319-2	1983	Heart rate, blood pressure, minute ventilation, and oxygen uptake in METS (1MET = 3.5 ml/kg/min) were determined at rest and at six submaximal work loads: 0.8, 1.0, 1.5, 2.0, 3.0 and 3.5mph, 0% grade.	Oxygen	52-58	ETS variant transcription factor 3	Homo sapiens	69-73
6639319-3	1983	The oxygen uptake versus walking speed (0.8 to 3.5mph) relationship was y = 0.2064 (x)2 + 0.0180 (x) + 1.7260 (y = METS and x = speed in mph), r = 0.99.	Oxygen	4-10	ETS variant transcription factor 3	Homo sapiens	115-119
6309819-2	1983	Likewise, during net ATP hydrolysis by the Mg2+-activated chloroplast ATPase, the extent of water oxygen incorporation into each Pi released increases as the ATP, GTP, or ITP concentration is decreased.	Oxygen	98-104	dynein axonemal heavy chain 8	Homo sapiens	70-76
6309819-6	1983	Activation of the chloroplast ATPase by either heat or trypsin results in similar catalytic behavior as monitored by ATP modulation of oxygen exchanges during hydrolysis in the presence of Mg2+.	Oxygen	135-141	dynein axonemal heavy chain 8	Homo sapiens	30-36
6309563-6	1983	The calmodulin antagonist W-7 attenuated AGEPC-mediated O2- production and cell spreading whereas prostanoid synthesis was enhanced.	Oxygen	56-58	calmodulin-2	Cavia porcellus	4-14
6881358-1	1983	Oxygen saturation of myoglobin (Mb) during the cardiac cycle was recorded spectrophotometrically by incorporating fiber optics in the isolated rat heart perfused using the Langendorff procedure.	Oxygen	0-6	myoglobin	Rattus norvegicus	21-30
6881358-1	1983	Oxygen saturation of myoglobin (Mb) during the cardiac cycle was recorded spectrophotometrically by incorporating fiber optics in the isolated rat heart perfused using the Langendorff procedure.	Oxygen	0-6	myoglobin	Rattus norvegicus	32-34
6881358-2	1983	Oxygen saturation of Mb was continuously measured from absorbancy increments at 581-592 nm of transmitted light through the left ventricular free wall.	Oxygen	0-6	myoglobin	Rattus norvegicus	21-23
6881358-3	1983	In addition, quantification in the Mb oxygen saturation induced by the change of wall thickness during cardiac cycle was assessed from the absorbance change at 568-592 nm, namely, dual wavelengths of two isosbestic points.	Oxygen	38-44	myoglobin	Rattus norvegicus	35-37
6881358-4	1983	The results show that to obtain actual Mb oxygen saturation the absorbance change induced by the change in the wall thickness has to be subtracted from the absorbance change of 581-592 nm and that the Mb oxygen saturation in a steady state determines the amount of subtraction.	Oxygen	42-48	myoglobin	Rattus norvegicus	39-41
6881358-4	1983	The results show that to obtain actual Mb oxygen saturation the absorbance change induced by the change in the wall thickness has to be subtracted from the absorbance change of 581-592 nm and that the Mb oxygen saturation in a steady state determines the amount of subtraction.	Oxygen	204-210	myoglobin	Rattus norvegicus	39-41
6881358-4	1983	The results show that to obtain actual Mb oxygen saturation the absorbance change induced by the change in the wall thickness has to be subtracted from the absorbance change of 581-592 nm and that the Mb oxygen saturation in a steady state determines the amount of subtraction.	Oxygen	204-210	myoglobin	Rattus norvegicus	201-203
6881358-5	1983	On the basis of these procedures, it was found that the myocardial Mb oxygen saturation and hence myocardial oxygen tension during pulsation in aerobic and anaerobic steady state did not vary during the cardiac cycle.	Oxygen	70-76	myoglobin	Rattus norvegicus	67-69
6881358-5	1983	On the basis of these procedures, it was found that the myocardial Mb oxygen saturation and hence myocardial oxygen tension during pulsation in aerobic and anaerobic steady state did not vary during the cardiac cycle.	Oxygen	109-115	myoglobin	Rattus norvegicus	67-69
6314839-4	1983	As these solutions can be rendered free of molecular oxygen, studies of the reactivity of HO2/O-2 with oxygen-sensitive compounds under virtually anaerobic conditions are possible.	Oxygen	53-59	heme oxygenase 2	Homo sapiens	90-97
6314839-4	1983	As these solutions can be rendered free of molecular oxygen, studies of the reactivity of HO2/O-2 with oxygen-sensitive compounds under virtually anaerobic conditions are possible.	Oxygen	103-109	heme oxygenase 2	Homo sapiens	90-97
16346268-1	1983	and Thiovulum spp., in O(2) and H(2)S Microgradients.	Oxygen	23-27	histocompatibility minor 13	Homo sapiens	14-17
6135442-10	1983	It is concluded that physical exercise which improves the maximal oxygen consumption decreases the use of beta 2-agonist spray and that heavy exercise is well tolerated by asthmatics.	Oxygen	66-72	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	106-112
6364198-4	1983	Cell division delay is influenced by oxygen in all strains but to a lesser extent in the rad2 mutant.	Oxygen	37-43	ssDNA endodeoxyribonuclease RAD2	Saccharomyces cerevisiae S288C	89-93
6297496-10	1982	The aerobic activation of nitrofurantoin by xanthine oxidase involved the superoxide anion as an intermediate, whereas the nitrofuran was directly reduced by ferredoxin-(cytochrome c)-NADP+ oxidoreductase without a requirement for active oxygen species.	Oxygen	238-244	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	190-204
7133514-0	1982	[Hyperbaric oxygen therapy as an aid in the neuromotor rehabilitation case of post-traumatic paraparesis].	Oxygen	12-18	activation induced cytidine deaminase	Homo sapiens	33-36
7159618-1	1982	The rate constants (kox) of irreversible oxidation of chlorophylls and porphyrins by 1 delta g state of oxygen (1O2) have been determined.	Oxygen	104-110	NADPH oxidase 4	Homo sapiens	20-23
7174405-1	1982	The effect of myoglobin on oxygen consumption and ATP production by isolated rat skeletal muscle mitochondria was studied under steady-state conditions of oxygen supply.	Oxygen	27-33	myoglobin	Rattus norvegicus	14-23
7174405-7	1982	During steady-state mitochondrial oxygen consumption, the oxygen pressure in the liquid phase is enhanced when myoglobin is present.	Oxygen	34-40	myoglobin	Rattus norvegicus	111-120
7174405-7	1982	During steady-state mitochondrial oxygen consumption, the oxygen pressure in the liquid phase is enhanced when myoglobin is present.	Oxygen	58-64	myoglobin	Rattus norvegicus	111-120
7174405-9	1982	Myoglobin functions in this system to enhance the flux of oxygen into the myoglobin-containing phase.	Oxygen	58-64	myoglobin	Rattus norvegicus	0-9
7174405-9	1982	Myoglobin functions in this system to enhance the flux of oxygen into the myoglobin-containing phase.	Oxygen	58-64	myoglobin	Rattus norvegicus	74-83
7174405-10	1982	Myoglobin may function in a similar fashion in muscle by increasing oxygen flux into myocytes.	Oxygen	68-74	myoglobin	Rattus norvegicus	0-9
6441605-1	1984	Monoamine oxidase type A activity with substrate serotonine and type B with substrate p-nitrophenylethylamine decreases is rats" brain, liver, heart and blood during oxygen convulsions.	Oxygen	166-172	monoamine oxidase A	Rattus norvegicus	0-24
6309777-3	1983	To investigate the molecular basis for the enhanced oxygen metabolite response, the kinetic parameters of the enzyme responsible for NADPH-dependent production of O-2 (NADPH oxidase) were compared in LPS-elicited and resident mouse peritoneal macrophages.	Oxygen	52-58	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	133-138
6309181-1	1983	Leukotriene B4 (LTB) was found to be metabolized by suspensions of rat liver microsomes in the presence of NADPH and oxygen.	Oxygen	117-123	lymphotoxin beta	Rattus norvegicus	16-19
6309777-3	1983	To investigate the molecular basis for the enhanced oxygen metabolite response, the kinetic parameters of the enzyme responsible for NADPH-dependent production of O-2 (NADPH oxidase) were compared in LPS-elicited and resident mouse peritoneal macrophages.	Oxygen	52-58	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	168-173
6832359-2	1983	Using the structure of glutathione reductase as a model, we suggest the following topography for leukocyte NADPH-oxidase: The binding sites of NADPH and O2 are separated from each other by the flavin ring and are thus exposed to opposite sides of the plasma membrane.	Oxygen	153-155	glutathione-disulfide reductase	Homo sapiens	23-44
6353042-8	1983	Stopping the oxygen supply to the perfusate suppressed kallikrein secretion in urine and renin release in the perfusate.	Oxygen	13-19	renin	Rattus norvegicus	89-94
6838991-5	1983	The theory is applied to the viscosity dependence of molecular oxygen-binding rates in sperm whale myoglobin.	Oxygen	63-69	myoglobin	Physeter catodon	99-108
6443594-8	1983	As a consequence of the Fe-S center B. subtilis amidophosphoribosyltransferase is oxygen-sensitive in vitro.	Oxygen	82-88	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	48-78
6443594-9	1983	Amidophosphoribosyltransferase from mammalian sources is similar to the B. subtilis enzyme in its oxygen-sensitivity which may result from an Fe-S center.	Oxygen	98-104	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	0-30
7153142-1	1982	We have investigated the O2-binding properties of the four embryonic hemoglobins (Hb P, Hb P", Hb M, and Hb E) under various conditions and compared the results with measurements on early embryonic chicken blood between 3 and 6 days of incubation.	Oxygen	25-27	hemoglobin subunit epsilon	Gallus gallus	105-109
6216920-0	1982	[Localization of the ATPase site of nitrogenase by isotopic oxygen exchange [180]-Pi in equilibrium with H20].	Oxygen	60-66	dynein axonemal heavy chain 8	Homo sapiens	21-27
7093528-0	1982	Effects of neuraminidase on O2 consumption and release of O2 and H2O2 from phagocytosing human polymorphonuclear leukocytes.	Oxygen	28-30	neuraminidase 1	Homo sapiens	11-24
6979941-3	1982	In HCO3-free solutions (100% O2), increasing serosal solution pH above 7 with either permeable or impermeable buffers caused Isc and G to increase; permeable buffers were somewhat more effective than impermeable buffers.	Oxygen	29-31	solute carrier family 25 member 3	Homo sapiens	62-64
6177495-7	1982	Loss of ABP was observed only when the animal was ventilated with about 5% O2 and this was secondary to and following cardiac failure and depressed arterial blood pressure, presumably leading to brain ischaemia.	Oxygen	75-77	amine oxidase copper containing 1	Homo sapiens	8-11
7098474-6	1982	For a polymer to display activity it must possess a base with an oxygen or sulfur atom at the C-6 position of purines or C-4 position of pyrimidines.	Oxygen	65-71	complement C6	Homo sapiens	94-97
7038471-1	1982	The extent of the oxygen effect for cell survival was studied in diploid and haploid wild-type yeast and in mutants belonging to the rad2, rad6 and rad50 epistatic group.	Oxygen	18-24	ssDNA endodeoxyribonuclease RAD2	Saccharomyces cerevisiae S288C	133-137
7038471-4	1982	In diploids the oxygen effect was decreased in rad2, rad52 and rad18.	Oxygen	16-22	ssDNA endodeoxyribonuclease RAD2	Saccharomyces cerevisiae S288C	47-51
7115978-2	1982	decrease of O2 saturation below 80-85% causes eta, eta" and eta" to increase progressively in SS cell suspensions and HbS solutions.	Oxygen	12-14	endothelin receptor type A	Homo sapiens	46-49
7115978-2	1982	decrease of O2 saturation below 80-85% causes eta, eta" and eta" to increase progressively in SS cell suspensions and HbS solutions.	Oxygen	12-14	endothelin receptor type A	Homo sapiens	51-54
7115978-2	1982	decrease of O2 saturation below 80-85% causes eta, eta" and eta" to increase progressively in SS cell suspensions and HbS solutions.	Oxygen	12-14	endothelin receptor type A	Homo sapiens	51-54
6274398-2	1981	The doses required for 50% inhibition were 0.58 mol myxothiazol/mol cytochrome b for oxygen consumption of beef heart mitochondria, and 0.45 mol/mol cytochrome b for NADH oxidation by submitochondrial particles.	Oxygen	85-91	cytochrome b	Saccharomyces cerevisiae S288C	68-80
6276338-1	1981	This study was undertaken to evaluate the effects of various training frequencies on performance capacity, the mitochondrial marker cytochrome c, and myoglobin, which is responsible for storage and transport of O2, in the three types of skeletal muscle.	Oxygen	211-213	myoglobin	Rattus norvegicus	150-159
6788082-2	1981	Oxygen-18 leaving group kinetic isotope effects (KIEs) have been determined on both Vmax (V) and Vmax/Km (V/K) for the beta-galactosidase-catalyzed hydrolysis of p-nitrophenyl beta-D-galactoside (I) and 2,4-dinitrophenyl beta-D-galactoside (II).	Oxygen	0-6	galactosidase beta 1	Homo sapiens	119-137
6165636-6	1981	Optimal aromatase activity was achieved by incubating cell-free sonicates at 37 degrees C in the presence of O2 in 20 mM phosphate buffer (pH 7.4) containing 5 mM dithiothreitol, 20 mM MgCl2, 0.5 mM NADP+, 20 mM glucose 6-phosphate and 2 U/ml glucose-6-phosphate dehydrogenase.	Oxygen	109-111	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	8-17
7208395-0	1981	Home oxygen therapy for COPD: practical aspects.	Oxygen	5-11	COPD	Homo sapiens	24-28
7208395-2	1981	In advanced chronic obstructive pulmonary disease (COPD), continuous oxygen therapy results in a higher survival rate than does administration of oxygen 12 hr/day.	Oxygen	69-75	COPD	Homo sapiens	51-55
7208395-2	1981	In advanced chronic obstructive pulmonary disease (COPD), continuous oxygen therapy results in a higher survival rate than does administration of oxygen 12 hr/day.	Oxygen	146-152	COPD	Homo sapiens	51-55
7208395-4	1981	Thus, oxygen therapy is now established care for selected patients with advanced COPD.	Oxygen	6-12	COPD	Homo sapiens	81-85
7208395-5	1981	Further studies are needed to evaluate the effectiveness of oxygen therapy to combat the possible effects of transient hypoxemia in patients with COPD during sleep or exercise.	Oxygen	60-66	COPD	Homo sapiens	146-150
6253570-0	1980	Lectin-dependent neutrophil-mediated cytotoxicity against chicken erythrocytes: a model of non-myeloperoxidase-mediated oxygen-dependent killing by human neutrophils.	Oxygen	120-126	galectin 3	Gallus gallus	0-6
6253570-0	1980	Lectin-dependent neutrophil-mediated cytotoxicity against chicken erythrocytes: a model of non-myeloperoxidase-mediated oxygen-dependent killing by human neutrophils.	Oxygen	120-126	eosinophil peroxidase	Gallus gallus	95-110
6790664-5	1980	Suspensions of bacteria that had been grown in the presence of haematin or catalase, respectively, translocated 0.83 to 1.98 and 1.33 to 2.53 protons per oxygen atom consumed in glycerol oxidation.	Oxygen	154-160	catalase	Bos taurus	75-83
7430093-1	1980	Rabbit liver microsomal cytochrome P-450 catalyzes the dealkylation of a variety of substrates when organic hydroperoxides, peracids, or peroxyesters are substituted for NADPH and O2.	Oxygen	180-182	cytochrome P-450	Oryctolagus cuniculus	24-40
7419231-0	1980	Oxygen desaturation in sleep: sleep apnea and COPD.	Oxygen	0-6	COPD	Homo sapiens	46-50
6773951-6	1980	The hemolytic activity of C3 was reduced by only 16%; the oxygen affinity of HbA2 was minimally decreased, and the phosphorylcholine binding affinity of an IgA myeloma protein (TEPC-15) was not significantly affected.	Oxygen	58-64	hemoglobin subunit alpha 2	Homo sapiens	77-81
6286925-4	1982	During hypoxia, 3,4-DAP (10 nM) increased in vitro ACh synthesis 67% (2.5% oxygen) and 63% (0% oxygen).	Oxygen	75-81	death associated protein	Homo sapiens	20-23
6286925-4	1982	During hypoxia, 3,4-DAP (10 nM) increased in vitro ACh synthesis 67% (2.5% oxygen) and 63% (0% oxygen).	Oxygen	95-101	death associated protein	Homo sapiens	20-23
6286925-5	1982	The Ca++-dependent-K+-stimulated release of ACh declined by 55 or 67% under 2.5 or 0% oxygen, respectively.3,4-DAP partially reversed this hypoxic impaired release of ACh under 2.5 (+69%) or 0% (+226%) oxygen.	Oxygen	86-92	death associated protein	Homo sapiens	111-114
6286925-5	1982	The Ca++-dependent-K+-stimulated release of ACh declined by 55 or 67% under 2.5 or 0% oxygen, respectively.3,4-DAP partially reversed this hypoxic impaired release of ACh under 2.5 (+69%) or 0% (+226%) oxygen.	Oxygen	202-208	death associated protein	Homo sapiens	111-114
6282659-1	1982	The site of oxygen binding during phenylalanine hydroxylase (PAH)-catalyzed turnover of phenylalanine to tyrosine has been tentatively identified as the 4a position of the tetrahydropterin cofactor, based on the spectral characteristics of an intermediate generated from both 6-methyltetrahydropterin and tetrahydrobiopterin during turnover.	Oxygen	12-18	phenylalanine hydroxylase	Homo sapiens	34-59
6282659-1	1982	The site of oxygen binding during phenylalanine hydroxylase (PAH)-catalyzed turnover of phenylalanine to tyrosine has been tentatively identified as the 4a position of the tetrahydropterin cofactor, based on the spectral characteristics of an intermediate generated from both 6-methyltetrahydropterin and tetrahydrobiopterin during turnover.	Oxygen	12-18	phenylalanine hydroxylase	Homo sapiens	61-64
6282966-4	1982	The complexes that maximally stimulate production of O(2) by neutrophils differ from those complexes that are 1) most effective in complement fixation, 2) maximally taken up by neutrophils, and 3) most effective in the induction of enzyme release.	Oxygen	53-57	VPS52 subunit of GARP complex	Homo sapiens	106-111
7091358-2	1982	Oxygen saturation of myoglobin, reduction of cytochrome aa3, and the dynamic wall thickness of the left ventricle were continuously and concurrently measured from absorbancy increments at 581-592 nm, 605-630 nm, and 568-592 nm, respectively.	Oxygen	0-6	myoglobin	Rattus norvegicus	21-30
7091358-4	1982	After 10 s of both anoxia and regional ischemia, oxygen saturation of myoglobin decreased by 50%, but fluorescence of nicotinamide adenine dinucleotide remained at aerobic level which indicated that mitochondrial oxidative energy production might still be maintained.	Oxygen	49-55	myoglobin	Rattus norvegicus	70-79
6281248-2	1982	Kinetic analysis of cytochrome c reduction by O2- generated by flash yielded the reaction rate constant between cytochrome c and O2- and the spontaneous disproportionation rate constant of O2-.	Oxygen	46-48	LOC104968582	Bos taurus	20-32
6281248-2	1982	Kinetic analysis of cytochrome c reduction by O2- generated by flash yielded the reaction rate constant between cytochrome c and O2- and the spontaneous disproportionation rate constant of O2-.	Oxygen	46-48	LOC104968582	Bos taurus	112-124
6281248-2	1982	Kinetic analysis of cytochrome c reduction by O2- generated by flash yielded the reaction rate constant between cytochrome c and O2- and the spontaneous disproportionation rate constant of O2-.	Oxygen	129-131	LOC104968582	Bos taurus	20-32
6281248-2	1982	Kinetic analysis of cytochrome c reduction by O2- generated by flash yielded the reaction rate constant between cytochrome c and O2- and the spontaneous disproportionation rate constant of O2-.	Oxygen	129-131	LOC104968582	Bos taurus	112-124
6281248-3	1982	We applied it for superoxide dismutase assay using a linear relation between superoxide dismutase concentration and the apparent rate constant of cytochrome c reduction by O2-.	Oxygen	172-174	LOC104968582	Bos taurus	146-158
7319893-6	1981	These findings suggest that cytochrome P-450 could act as a carrier for O2 and CO in tissue with low PO2"s.	Oxygen	72-74	cytochrome P-450	Oryctolagus cuniculus	28-44
6894154-10	1981	The data suggest that rat lung is susceptible to injury by a variety of oxygen metabolites, including O2-, H2O2 and its lactoperoxidase or myeloperoxidase-produced derivatives.	Oxygen	72-78	lactoperoxidase	Rattus norvegicus	120-135
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Oxygen	38-44	microtubule affinity regulating kinase 2	Homo sapiens	142-148
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Oxygen	68-74	microtubule affinity regulating kinase 2	Homo sapiens	142-148
7468251-3	1980	Three-fold elevation of Cap2+, from 1.3 to 3.9 mM restored contractility and O2-consumption while enhancing the increase of TCR.	Oxygen	77-79	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	24-28
6828881-3	1983	This high mobility allows the oxygenated form of myoglobin to contribute significantly to the overall diffusive flux of oxygen in respiring heart muscle.	Oxygen	30-36	myoglobin	Bos taurus	49-58
6249586-0	1980	On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency.	Oxygen	110-116	dihydroorotate dehydrogenase	Mus musculus	15-43
16661754-5	1981	Glutamate dehydrogenase was confirmed as a matrix enzyme.Both proline and Delta(1)-pyrroline-5-carboxylic acid supported oxygen uptake in isolated mitochondria.	Oxygen	121-127	glutamic dehydrogenase1	Zea mays	0-23
6835721-2	1983	As the deleterious effect of oxygen derivatives in the cell is one of the numerous pathways associated with cell aging, the activity of the enzymatic defense system, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione reductase (GR), was examined in the erythrocytes of 12 CF children and was compared to age-matched normal controls.	Oxygen	29-35	glutathione-disulfide reductase	Homo sapiens	226-247
7260981-3	1981	A considerable myocardial oxygen gradient was detected using myoglobin deoxygenation as an indicator.	Oxygen	26-32	myoglobin	Rattus norvegicus	61-70
7351547-2	1980	Previous studies in man have revealed a coupling between the regional cerebral blood flow (rCBF) and the regional cerebral metabolic rate for oxygen.	Oxygen	142-148	CCAAT/enhancer binding protein zeta	Rattus norvegicus	91-95
7351547-3	1980	In normal man, increases in the regional cerebral metabolic rate for oxygen leads to proportional increases in the rCBF(34).	Oxygen	69-75	CCAAT/enhancer binding protein zeta	Rattus norvegicus	115-119
6835721-2	1983	As the deleterious effect of oxygen derivatives in the cell is one of the numerous pathways associated with cell aging, the activity of the enzymatic defense system, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione reductase (GR), was examined in the erythrocytes of 12 CF children and was compared to age-matched normal controls.	Oxygen	29-35	glutathione-disulfide reductase	Homo sapiens	249-251
6257420-0	1981	Angiotensin-converting enzyme activity and its modulation by oxygen tension in the guinea pig fetal-placental unit.	Oxygen	61-67	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	0-29
6340725-7	1983	By contrast, the DNA backbone of Pf1 is uniformly oriented such that all of the phosphodiester groups have the O-P-O plane of the nonesterified oxygens approximately perpendicular to the filament axis.	Oxygen	144-151	PHD finger protein 12	Homo sapiens	33-36
6257420-1	1981	Angiotensin-converting enzyme (ACE) activity in the guinea pig fetal-placental unit was assessed at the different oxygen tensions found in utero, during labor, and at birth.	Oxygen	114-120	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	0-29
6257420-1	1981	Angiotensin-converting enzyme (ACE) activity in the guinea pig fetal-placental unit was assessed at the different oxygen tensions found in utero, during labor, and at birth.	Oxygen	114-120	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	31-34
42447-4	1979	2,4-Diisopropyldeuteroheme-myoglobin showed a four times lower oxygen affinity at 25 degrees C and larger enthalpy and entropy changes of oxygenation than the corresponding values of native myoglobin.	Oxygen	63-69	myoglobin	Physeter catodon	27-36
7344454-0	1981	The heme protein P-450 in oxygen activation: carbon monoxide inhibition and photochemical action spectroscopy as tools to study its catalytic role.	Oxygen	26-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	17-22
6304829-7	1983	When high-flow hypoxia and ischemia were compared at the same rates of oxygen delivery, the developed tension at any level of cytochrome c reduction was always lower with ischemia than with high-flow hypoxia.	Oxygen	71-77	cytochrome c	Oryctolagus cuniculus	126-138
479163-2	1979	Xanthine dehydrogenase engaged in catalyzing the oxidation of substrate by oxygen is repidly inactivated by the hydrogen peroxide generated during the reaction.	Oxygen	75-81	xanthine dehydrogenase	Gallus gallus	0-22
7449101-1	1981	We describe the measurement of lipase (triacylglycerol lipase; EC 3.1.1.3) in serum by continuous monitoring of relative rates of oxygen consumption with a polarographic oxygen electrode.	Oxygen	130-136	lipase C, hepatic type	Homo sapiens	39-61
6304829-9	1983	Myoglobin deoxygenation was linearly related to cytochrome c reduction under all conditions of hypoxia, indicating steep oxygen gradients.	Oxygen	12-18	cytochrome c	Oryctolagus cuniculus	48-60
7449101-1	1981	We describe the measurement of lipase (triacylglycerol lipase; EC 3.1.1.3) in serum by continuous monitoring of relative rates of oxygen consumption with a polarographic oxygen electrode.	Oxygen	170-176	lipase C, hepatic type	Homo sapiens	39-61
452501-1	1979	Substrate specificity of monoamine oxidase (MAO) of the A type from rat brain and liver tissues was altered after exposure of rats to an increased oxygen pressure [4 ati O2, 1 hr].	Oxygen	147-153	monoamine oxidase A	Rattus norvegicus	25-42
452501-1	1979	Substrate specificity of monoamine oxidase (MAO) of the A type from rat brain and liver tissues was altered after exposure of rats to an increased oxygen pressure [4 ati O2, 1 hr].	Oxygen	147-153	monoamine oxidase A	Rattus norvegicus	44-47
452501-4	1979	Alterations in catalytic properties of MAO of the A type were apparently important in development of the oxygen intoxication.	Oxygen	105-111	monoamine oxidase A	Rattus norvegicus	39-42
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	46-53	complement component 3	Mus musculus	63-66
37557-3	1979	Bovine liver xanthine oxidase and chicken liver xanthine dehydrogenase with oxygen as electron acceptor exhibit similar profile in pKM and log V versus pH plots.	Oxygen	76-82	xanthine dehydrogenase	Gallus gallus	48-70
761831-2	1979	Experimental PCI was produced in cadavers using high pressure oxygen insuflation of the lungs, thus lending support to the theory that it has a mechanical origin.	Oxygen	62-68	serpin family A member 5	Homo sapiens	13-16
730360-6	1978	This unique response to Cd2+ may be related to general metabolic characteristics of these cells living at an elevated O2 tension.	Oxygen	118-120	CD2 antigen	Mus musculus	24-27
670189-7	1978	Presence of this component, which is likely a contaminating ATPase, provides a simple explanation of the apparent nonequivalence of phosphate oxygens which has been observed.	Oxygen	142-149	dynein axonemal heavy chain 8	Homo sapiens	60-66
656405-3	1978	At concentrations of Tris sufficient to inhibit O2 evolution directly, a slow rate (t 1/2 approximately 20--25 min) of inactivation occurs; 2.	Oxygen	48-50	interleukin 1 receptor like 1	Homo sapiens	84-87
656405-8	1978	The life-time (t 1/2 approximately 1 to 3 h) of the activable state is correlated with diffusion across thylakoids of the larger manganese pool released from binding sites and remaining in thylakoids following inactivation of O2 evolution.	Oxygen	226-228	interleukin 1 receptor like 1	Homo sapiens	15-36
649471-4	1978	On 80:20 helium-oxygen mixture Vmax 50 during maximal expiration (MEFV) decreased from 4.9 +/- 0.61 to 3.4 +/- 0.61 l/s (P greater than 0.005) and during PEFV diminished from 4.6 +/- 0.61 to 2.8 +/- 0.46 l/s (P greater than 0.005).	Oxygen	16-22	MEFV innate immuity regulator, pyrin	Homo sapiens	66-70
643379-4	1978	Glucose-6-phosphate dehydrogenase was significantly elevated in the 72-hr oxygen-exposed adult rats.	Oxygen	74-80	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
17607-1	1977	Interaction of sperm whale myoglobin and Glycera hemoglobin with molecular oxygen.	Oxygen	75-81	myoglobin	Physeter catodon	27-36
17607-2	1977	The pH dependence of the electron paramagnetic resonance (EPR) spectrum and oxygen affinity of cobaltous porphyrin-containing myoglobin (CoMb) have been examined.	Oxygen	76-82	myoglobin	Physeter catodon	126-135
857966-3	1977	It is assumed that renin and erythropoietin could be regarded as two links of the same broad control system, responsible for optimum tissue oxygen supply.	Oxygen	140-146	renin	Rattus norvegicus	19-24
1276004-3	1976	The output of the Fluotec Mark 2 at the 0.5 and 1% settings was highest with nitrous oxide as the carrier gas, but at 2, 3 and 4% settings it was highest with oxygen; at the 0.5% and 1% dial settings it was a function of carrier gas density, but at 2%, 3% and 4% it was a function of carrier gas viscosity.	Oxygen	159-165	microtubule affinity regulating kinase 2	Homo sapiens	26-32
938238-0	1976	[Changes in the brain acetylcholinesterase activity in mice treated with o-ethyl-s-(2-diisopropyl-aminothyl)methyl thiophosphonate vx and exposed to high oxygen concentrations in the air].	Oxygen	154-160	acetylcholinesterase	Mus musculus	22-42
1176457-4	1975	The NADPH oxidase activity observed in the presence of adrenodoxin reductase, adrenodoxin, and O2, but in the absence of cytochrome P-450 and deoxycorticosterone, were functions of O2 and adrenodoxin concentrations and represented the autooxidation of reduced adrenodoxin which resulted in the production of H2O2.	Oxygen	181-183	ferredoxin reductase	Homo sapiens	55-76
239615-12	1975	These results, along with the increased oxygen utilization (ZO2) values produced by adding uterine tubal fluid to the incubation mediums, might indicate utilization of a uterine tubal substrate.	Oxygen	40-46	tight junction protein 2	Homo sapiens	60-63
1118738-9	1975	Thus, an organism normally killed by the peroxidase system may be handled less efficiently but adequately when MPO is absent by other oxygen-dependent antimicrobial systems.	Oxygen	134-140	eosinophil peroxidase	Gallus gallus	111-114
4239123-0	1969	ATPase content of striated muscle stressed in O2-CO2 and hyperbaric N2-O2-CO2 atmospheres.	Oxygen	46-48	dynein axonemal heavy chain 8	Homo sapiens	0-6
4239123-0	1969	ATPase content of striated muscle stressed in O2-CO2 and hyperbaric N2-O2-CO2 atmospheres.	Oxygen	50-52	dynein axonemal heavy chain 8	Homo sapiens	0-6
5664222-4	1968	When the inhibition of protocollagen hydroxylase was reversed by exposing the tissue to oxygen, the accumulated protocollagen-(3)H was converted to collagen-(3)H and there was a rapid transfer of label from the ground cytoplasm to the extracellular matrix.	Oxygen	88-94	prolyl 4-hydroxylase subunit beta	Homo sapiens	23-48
4388687-7	1968	The enzyme is a dehydrogenase, unable to utilize oxygen, NAD, NADP, flavines or menadione as electron acceptors, but able to utilize phenazine methosulphate, ferricyanide, cytochrome c or brilliant cresyl blue.	Oxygen	49-55	MEXAM1_RS21720	Methylobacterium extorquens AM1	16-29
6048326-0	1967	Oxygen-18 studies with citrate synthase.	Oxygen	0-6	citrate synthase	Homo sapiens	23-39
14297417-0	1964	[EFFECT OF ACTH ON THE RATE OF THE GLUCOKINASE REACTION IN THE TISSUES OF WHITE RATS IN STATES OF ACUTE OXYGEN INSUFFICIENCY IN THE BODY].	Oxygen	104-110	glucokinase	Rattus norvegicus	35-46
33960360-2	2021	Complexes 2a and 2b can be oxidized by a small amount of oxygen at low temperature leading to oxygen-bridged dinuclear Ni(ii) complexes (dmpBIANNi)2(mu-O)2 (4a) and (dippBIANNi)2(mu-O)2 (4b), respectively, as a purple powder.	Oxygen	57-63	adaptor related protein complex 1 subunit mu 2	Homo sapiens	119-185
33960360-2	2021	Complexes 2a and 2b can be oxidized by a small amount of oxygen at low temperature leading to oxygen-bridged dinuclear Ni(ii) complexes (dmpBIANNi)2(mu-O)2 (4a) and (dippBIANNi)2(mu-O)2 (4b), respectively, as a purple powder.	Oxygen	94-100	adaptor related protein complex 1 subunit mu 2	Homo sapiens	119-185
33756232-3	2021	We previously showed that IL-33 -induced endogenous reactive oxygen species is required for optimal metabolic activation of ILC2 functions, however, the role of exogenous oxidative stress in regulating ILC2 functions has not been investigated.	Oxygen	61-67	interleukin 33	Homo sapiens	26-31
33894355-4	2021	In the present perspective, therefore, we discuss the hypothesis that endothelial Kir2.1 channels and NMDARs play a key role in NVC and in CBF regulation, which is crucial to unravel the cellular and molecular underpinnings of blood oxygen level-dependent signals.	Oxygen	233-239	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	82-88
33632987-11	2021	The expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin were increased after hES-MSCs were incubated for 48 h in 2% O2 condition.	Oxygen	120-122	angiogenin	Homo sapiens	49-59
33632987-12	2021	Conclusions: The hES-MSCs viability and expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin increased after 48 h incubation in 2% O2 condition.	Oxygen	134-136	angiogenin	Homo sapiens	85-95
33619534-6	2021	Mechanistically, Twist1 deletion induces transactivation of voltage-gated calcium channel (VGCC) Cacna1b which exhausts Ly-biased HSCs, impairs genotoxic hematopoietic recovery, and enhances mitochondrial calcium levels, metabolic activity, and reactive oxygen species production.	Oxygen	254-260	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	97-104
7407339-1	1980	The supply of heterotrophically growing suspensions of Alcaligenes eutrophus PHB-4 with oxygen formed by the continuous addition of H2O2 in the presence of bovine liver catalase was found to be restricted to well-defined conditions.	Oxygen	88-94	catalase	Bos taurus	169-177
7407339-5	1980	The impairment of growth observed during the oxygen supply by the catalase-H2O2 system was traced back to the formation of gradually increasing steady-state concentrations of H2O2 in the medium.	Oxygen	45-51	catalase	Bos taurus	66-74
7426435-1	1980	Successful application of pyridoxal 5"-phosphate (PLP) to restore the oxygen transport function of ACD-stored blood is described.	Oxygen	70-76	pyridoxal phosphatase	Homo sapiens	50-53
7426435-6	1980	PLP incorporated into erythrocytes restores the oxygen transport function of the ACD-erythrocytes, though decreased haem--haem interaction is observed.	Oxygen	48-54	pyridoxal phosphatase	Homo sapiens	0-3
7372025-4	1980	It is proposed that the greater proportion of higher oxygen-affinity HbA1 in comparatively uncontrolled diabetics may be inducing sufficient tissue hypoxia to cause the demonstrated relative polycythaemia.	Oxygen	53-59	hemoglobin subunit alpha 1	Homo sapiens	69-73
7468245-1	1980	The effect of changes in extracellular calcium ion concentration (Cap2+) on myocardial resting O2 consumption (QO2R) was studied by direct ("cardiac arrest") and indirect (extrapolation) methods in the isolated rat heart perfused by the modified Langendorff technique.	Oxygen	95-97	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	66-70
7468245-5	1980	Elevation of Cap2+ from 1.3 to 2.6 mM increased O2 consumption from 2.4 +/- 0.6 to 4.1 +/- 0.5 ml/100 g/min, when heart beat was abolished by 2 mM Ni2+.	Oxygen	48-50	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	13-17
7468250-4	1980	At high Cap2+ (2.6--7.8 mM) increase of contractile activity and O2-consumption was accompanied by Cap2+ dependent NAD+ reduction in the presence of glucose.	Oxygen	65-67	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	8-12
7398725-5	1980	Oxygen step-up was greater in patients with MVP (P less than 0.05).	Oxygen	0-6	major vault protein	Homo sapiens	44-47
465681-1	1979	A rise of hemoglobin concentration accompanied by an increase of the total iron in the blood serum of white mice was found under oxygen pressure of 4 atm for an hour (preconvulsive state) and 6 atm (convulsive state).	Oxygen	129-135	ataxia telangiectasia mutated	Mus musculus	150-153
34043350-6	2021	Moreover, these radicals can also react with O2 - with rate constants (kSO) from 1.2 x 103 M-1 s-1 for ET-01 to 1.6 x 104 M-1 s-1 for TGA.	Oxygen	45-47	T-box transcription factor 1	Homo sapiens	134-137
34038084-7	2021	Moreover, favorable ion-dipole interactions between alkali metal cations and oxygen atoms of the monomer facilitated two-dimensional growth and the formation of a purely microporous framework in the case of CICF-KCl/NaCl along with a near theoretical retention of the nitrogen content at 500  C. The CICF-KCl/NaCl showed a BET surface area of 590 m2 g-1 along with a CO2 uptake capacity of 5.9 mmol g-1 at 273 K and 1.1 bar because of its high microporosity and nitrogen content.	Oxygen	77-83	delta/notch like EGF repeat containing	Homo sapiens	323-326
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	46-53	complement component 3	Mus musculus	72-75
153910-1	1979	The capacity of various ATPase preparations from beef heart mitochondria to catalyze exchange of phosphate oxygens with water has been evaluated.	Oxygen	107-114	dynein axonemal heavy chain 8	Homo sapiens	24-30
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	114-121	complement component 3	Mus musculus	63-66
42252-8	1979	b) Molecular oxygen was reduced to HO2- and H2O2, respectively.	Oxygen	13-19	heme oxygenase 2	Homo sapiens	35-38
34058588-2	2021	Our study emphasizes revealing the mechanisms of chemical oxygen demand/total nitrogen (COD/TN) ratio dependent improved greywater (GW) treatment in an oxygen based membrane biofilm reactor (O2-MBfR).	Oxygen	58-64	C-type lectin domain family 3 member B	Homo sapiens	92-94
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	114-121	complement component 3	Mus musculus	72-75
34058588-2	2021	Our study emphasizes revealing the mechanisms of chemical oxygen demand/total nitrogen (COD/TN) ratio dependent improved greywater (GW) treatment in an oxygen based membrane biofilm reactor (O2-MBfR).	Oxygen	152-158	C-type lectin domain family 3 member B	Homo sapiens	92-94
6961918-0	1982	Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity.	Oxygen	129-131	xanthine dehydrogenase	Rattus norvegicus	98-121
34058588-4	2021	Reducing COD/TN ratio also led to an increase in the ammonia monooxygenase (AMO) activity (from 7.56 to 10.2 mg N/g VSS-h), as well as improved ammoxidation and linear alkylbenzene sulfonate (LAS) mineralization although the dissolved oxygen (DO) concentration and pH decreased.	Oxygen	65-71	C-type lectin domain family 3 member B	Homo sapiens	13-15
510325-7	1979	Oxygen unloading was, however, improved when SFH-PLP with low oxygen affinity was used.	Oxygen	0-6	proteolipid protein 1	Canis lupus familiaris	49-52
510325-7	1979	Oxygen unloading was, however, improved when SFH-PLP with low oxygen affinity was used.	Oxygen	62-68	proteolipid protein 1	Canis lupus familiaris	49-52
510325-8	1979	Thus, SFH-PLP merits further consideration as a short-term oxygen-carrying blood substitute.	Oxygen	59-65	proteolipid protein 1	Canis lupus familiaris	10-13
7138833-1	1982	The recombination after flash photolysis of dioxygen and carbon monoxide with sperm whale myoglobin (Mb), and separated beta chains of human hemoglobin (beta A) and hemoglobin Zurich (beta ZH), has been studied as a function of pH and temperature from 300 to 60 K. At physiological temperatures, a preequilibrium is established between the ligand molecules in the solvent and in the heme pocket.	Oxygen	44-52	myoglobin	Physeter catodon	90-99
33949520-4	2021	At a later time of the reaction, absorption bands of H2O and formyl chloride (CHClO) at 1782.9 cm-1 were observed; these species were likely produced from the secondary reactions of CH2ClO + O2   CHClO + HO2 and OH + HCl   H2O + Cl according to temporal profiles of CMHP, H2O, and CHClO; formation of CH2ClO + OH via decomposition of internally excited CMHP was predicted by theory and both HCl and O2 are major species in the system.	Oxygen	191-193	heme oxygenase 2	Homo sapiens	204-207
31920-0	1978	Acid Bohr effects in myoglobin characterized by proton NMR hyperfine shifts and oxygen binding studies.	Oxygen	80-86	myoglobin	Physeter catodon	21-30
7113886-4	1982	Oxygen consumption rate standardized for weight is expressed in METS.	Oxygen	0-6	ETS variant transcription factor 3	Homo sapiens	64-68
31920-5	1978	Oxygen binding studies of sperm whale myoglobin over a range of temperature and pH showed that, while the oxygen affinity was independent of pH at 25 degrees C, it increased below pH 7 at 0 degrees C and decreased below pH 7 at 37 degrees C. Hence, sperm whale myoglobin exhibits a small acid Bohr effect which most likely arises from the characterized structural changes in the deoxy proteins.	Oxygen	0-6	myoglobin	Physeter catodon	38-47
31920-5	1978	Oxygen binding studies of sperm whale myoglobin over a range of temperature and pH showed that, while the oxygen affinity was independent of pH at 25 degrees C, it increased below pH 7 at 0 degrees C and decreased below pH 7 at 37 degrees C. Hence, sperm whale myoglobin exhibits a small acid Bohr effect which most likely arises from the characterized structural changes in the deoxy proteins.	Oxygen	106-112	myoglobin	Physeter catodon	38-47
31920-5	1978	Oxygen binding studies of sperm whale myoglobin over a range of temperature and pH showed that, while the oxygen affinity was independent of pH at 25 degrees C, it increased below pH 7 at 0 degrees C and decreased below pH 7 at 37 degrees C. Hence, sperm whale myoglobin exhibits a small acid Bohr effect which most likely arises from the characterized structural changes in the deoxy proteins.	Oxygen	106-112	myoglobin	Physeter catodon	261-270
28215-0	1978	Changes in blood oxygen and in cardiac function following beta2 and other bronchodilator drugs.	Oxygen	17-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	58-63
643379-2	1978	Examination of the lungs of neonatal rats, who survived 5 days of oxygen exposure with no evidence of respiratory distress, showed significant increases in the pulmonary superoxide dismutase (SOD) activity (peak value: 144% of air-exposed controls), glutathione peroxidase (GP) activity (126%), glutathione reductase (GR) activity (122%), reduced glutathione (GSH) level (176%), and glucose-6-phosphate dehydrogenase activity (151%).	Oxygen	66-72	glucose-6-phosphate dehydrogenase	Rattus norvegicus	383-416
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	163-169	matrix metallopeptidase 2	Homo sapiens	5-31
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	163-169	matrix metallopeptidase 2	Homo sapiens	33-37
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	163-169	transforming growth factor alpha	Homo sapiens	123-130
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	336-342	matrix metallopeptidase 2	Homo sapiens	5-31
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	336-342	matrix metallopeptidase 2	Homo sapiens	33-37
33751758-3	2021	Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFbeta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing the photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy.	Oxygen	336-342	transforming growth factor alpha	Homo sapiens	123-130
33784258-7	2021	Down-regulation of PLIN2 decreased specific OXPHOS proteins in all three models and reduced oxygen consumption rates in INS1 cells and mouse islets.	Oxygen	92-98	perilipin 2	Rattus norvegicus	19-24
562675-0	1977	Linkage between the binding sites for zinc and oxygen on sperm whale myoglobin.	Oxygen	47-53	myoglobin	Physeter catodon	69-78
7131937-2	1982	Glucagon and norepinephrine in a dose of 100 microgram/100 g caused a marked increase in oxygen consumption.	Oxygen	89-95	glucagon	Mus musculus	0-8
892715-4	1977	This interpretation is based on the exchange of the 2,3-diphosphoglycerate contact beta2His leads to Asn from man to llama: the interaction between the heterotropic allosteric effector 2,3-diphosphoglycerate and protein is diminished, which results in higher oxygen affinity of the hemoglobin of llama.	Oxygen	259-265	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	83-88
33969448-2	2021	Lack of the protein mitochondrial calcium uptake1 (MICU1), which has been regarded as a gatekeeper of Ca ions, leads to the abnormal mitochondrial Ca2+ handling, excessive production of reactive oxygen species (ROS), and increased cell death.	Oxygen	195-201	mitochondrial calcium uptake 1	Homo sapiens	51-56
7168211-11	1982	It follows that by this process the utilization eta of oxygen-binding capacity of blood is much more improved than hitherto supposed (see measurement given in the text: decrease of pO2-ven from 40 mm Hg (5.3 kPa) to 27 mm Hg (3.6 kPa).	Oxygen	55-61	endothelin receptor type A	Homo sapiens	48-51
34026753-6	2021	Furthermore, treatment with rosuvastatin on AS mouse model and H2O2-induced HUVEC injury model showed a protective effect against AS by inhibiting the Pyk2/MCU pathway, which maintained calcium balance, prevented the mitochondrial damage and reactive oxygen species production, and eventually inhibited cell apoptosis.	Oxygen	251-257	PTK2 protein tyrosine kinase 2 beta	Mus musculus	151-155
34026753-6	2021	Furthermore, treatment with rosuvastatin on AS mouse model and H2O2-induced HUVEC injury model showed a protective effect against AS by inhibiting the Pyk2/MCU pathway, which maintained calcium balance, prevented the mitochondrial damage and reactive oxygen species production, and eventually inhibited cell apoptosis.	Oxygen	251-257	mitochondrial calcium uniporter	Mus musculus	156-159
17751-1	1977	In the histamine H2-receptor antagonist metiamide (2a) isosteric replacement of thione sulfur (=S) by carbonyl oxygen (=O) or imino nitrogen (=NH) affords the urea 2c and guanidine 2d which are antagonists of decreased potency.	Oxygen	111-117	histamine receptor H2	Homo sapiens	7-28
6794956-3	1981	Normal or increased activities were found for certain erythrocyte enzymes involved in the detoxification of activated oxygen: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase.	Oxygen	118-124	glutathione-disulfide reductase	Homo sapiens	198-219
618355-6	1977	The changes in the ODC"s are thought to be secondary to the hyperchylomicronemia for the following reasons: (1) the change was minimized by incubating red cells from the patients in normal donor plasma; (2) normal red cells increased their oxygen affinity when incubated in lactescent plasma; (3) the change was not explainable by a decrease in red cell 2,3-diphosphoglycerate content or in arterial blood hydrogen ion concentration.	Oxygen	240-246	ornithine decarboxylase 1	Homo sapiens	19-22
577057-2	1977	Together with oxidation-reduction of the oxygen functions at C-3 and C-17 hydroxylation occurred at C-15, C-16, and at the 2alpha-methyl positions of the steroid nucleus.	Oxygen	41-47	complement C3 alpha chain	Oryctolagus cuniculus	61-64
947404-9	1976	Finally, we found an abnormal oxygen consumption of the propositus" PMNs after phagocytosis of zymosan particles, suggesting that the glutathione reductase reaction was involved in the bactericidal capacity of these cells.	Oxygen	30-36	glutathione-disulfide reductase	Homo sapiens	134-155
33947901-4	2021	The EDA can crosslink oxygen-containing groups of GO, enhancing the mechanical properties of the GO/EDA coating with hardness and elastic modulus values up to 1.14 and 28.7 GPa, respectively.	Oxygen	22-28	ectodysplasin A	Homo sapiens	4-7
33947901-4	2021	The EDA can crosslink oxygen-containing groups of GO, enhancing the mechanical properties of the GO/EDA coating with hardness and elastic modulus values up to 1.14 and 28.7 GPa, respectively.	Oxygen	22-28	ectodysplasin A	Homo sapiens	100-103
33783055-3	2021	To solve this material dilemma, herein, a novel morphological and structural design is introduced to Li1.11 Mn0.49 Ni0.29 Co0.11 O2 , reporting a sub-micrometer-level LMR with a relatively delocalized, excess-Li system.	Oxygen	129-131	transglutaminase 1	Homo sapiens	101-104
34028209-4	2021	Here, optogenetics is used to spatiotemporally control MRTF-A nuclear localization by blue light using the light-oxygen-voltage-sensing domain 2-domain based system LEXY (light-inducible nuclear export system).	Oxygen	113-119	myocardin related transcription factor A	Homo sapiens	55-61
33722639-3	2021	GO enrichment annotation indicated that the predicted downstream targets miR-485-5p were enriched in hypoxia response and decreased oxygen level.	Oxygen	132-138	microRNA 485	Homo sapiens	73-80
33932953-10	2021	ABSTRACT: Tumor necrosis factor-alpha (TNFalpha) activates NADPH Oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs), producing superoxide (O2  - ) required for subsequent signaling.	Oxygen	145-150	NADPH oxidase 1	Homo sapiens	59-74
33932953-10	2021	ABSTRACT: Tumor necrosis factor-alpha (TNFalpha) activates NADPH Oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs), producing superoxide (O2  - ) required for subsequent signaling.	Oxygen	145-150	NADPH oxidase 1	Homo sapiens	76-80
33760137-8	2021	It was found that transfection with a microRNA (miR)-125b agomir and a small interfering RNA (si)-foxp3 plasmid reversed the inhibitory effect induced by tanshinone IIA, accompanied by an increase in reactive oxygen species levels and lactate dehydrogenase release, indicating a critical role of miR-125b/foxp3 signaling in pyroptosis in HK1 cells.	Oxygen	209-215	forkhead box P3	Homo sapiens	98-103
33932464-7	2021	Based on these findings, we found a small-molecule drug, M12, that interrupted the TRPV4-Nox2 interaction, thereby reducing inflammatory factors and reactive oxygen species production and helping to restore the vasodilatory function.	Oxygen	158-164	cytochrome b-245, beta polypeptide	Mus musculus	89-93
33870400-6	2021	To support the proposed mechanisms, we investigated the gas sensor response of SnO2 nanobelts with a higher quantity of oxygen vacancies and correlated the results to the SnO system.	Oxygen	120-126	strawberry notch homolog 1	Homo sapiens	79-82
33893167-0	2021	S1P2-Galpha12 signaling inhibits astrocytic glutamate uptake and mitochondrial oxygen consumption.	Oxygen	79-85	sphingosine-1-phosphate receptor 2	Mus musculus	0-4
33883134-3	2021	Electron energy-loss spectroscopy and density functional theory (DFT) calculations provide direct evidence of oxygen vacancy (V O) formation at the LAO (111) surface, which acts as the source of 2DEG.	Oxygen	110-116	interleukin 4 induced 1	Homo sapiens	148-151
33592181-6	2021	Cells expressing other CYPs had an even stronger effect, with those expressing CYP2B6, CYP5A1, CYP2A13, CYP51A1, or CYP1A2, respectively, being the strongest producers of O2- .	Oxygen	171-174	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-85
33601161-6	2021	During the fragmentation process of dolutegravir and its degradation products DP1 to DP3 a formal addition of oxygen resulting in the respective carboxylic acid fragments was detected.	Oxygen	110-116	prostaglandin D2 receptor	Homo sapiens	78-81
33601161-6	2021	During the fragmentation process of dolutegravir and its degradation products DP1 to DP3 a formal addition of oxygen resulting in the respective carboxylic acid fragments was detected.	Oxygen	110-116	APC regulator of WNT signaling pathway	Homo sapiens	85-88
33857507-8	2021	As a result, CS-LLNEs film presented higher water vapor and oxygen barrier abilities and mechanical properties in comparison with CS-LL film.	Oxygen	60-66	citrate synthase	Homo sapiens	13-15
33480460-5	2021	We further demonstrate the application of the nanosensors for the imaging of subcellular APE1 translocation in response to oxygen stress in live cells.	Oxygen	123-129	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	89-93
32572800-8	2021	Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-alpha (P <= 0.0001) and IL-10 (P <= 0.012) contents, and significant elevation in IFN-gamma (P <= 0.0002) content on day 14 post-therapy.	Oxygen	41-44	interleukin-10	Bos taurus	114-119
33571167-3	2021	Here we show that the innate immune transcription factor IRF3 is a strong repressor of thermogenic gene expression and oxygen consumption in adipocytes.	Oxygen	119-125	interferon regulatory factor 3	Mus musculus	57-61
33354851-0	2021	Editorial for: "3D Oxygen-Enhanced MR Imaging at 3T MR System: Comparison With Thin-Section CT of Quantitative Capability for Pulmonary Functional Loss Assessment and Clinical Stage Classification of COPD in Smokers".	Oxygen	19-25	COPD	Homo sapiens	200-204
34012567-7	2021	Results: The amounts of elastin, muscle, and collagen and the protein levels of ET-1, HIF-1alpha, Rock-1, and MMP-2, increased significantly with decreased oxygen saturation in the perfusion circuit.	Oxygen	156-162	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	98-104
34012567-7	2021	Results: The amounts of elastin, muscle, and collagen and the protein levels of ET-1, HIF-1alpha, Rock-1, and MMP-2, increased significantly with decreased oxygen saturation in the perfusion circuit.	Oxygen	156-162	matrix metallopeptidase 2	Homo sapiens	110-115
32896217-9	2021	Suppression of DON induced reactive oxygen species by AtLTP4.4 might be the mechanism by which fungal spread and mycotoxin accumulation are inhibited in the transgenic wheat plants.	Oxygen	36-42	lipid transfer protein 4	Arabidopsis thaliana	54-60
33338865-9	2021	For example, the amount of OH determined by the Weissler and Fricke methods may have some uncertainty due to the formation of HO2 in the presence of oxygen.	Oxygen	149-155	heme oxygenase 2	Homo sapiens	126-129
1275087-2	1976	After 7 days of exposure to 90% O2 (1atm), superoxide dismutase activities in mitochondrial and cytosolic fractions increased, respectively, to 245 and 145% of control; glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities increased, respectively, to 317, 175, and 413% of control.	Oxygen	32-34	glucose-6-phosphate dehydrogenase	Rattus norvegicus	220-253
6224-6	1976	All the enzymes in both tissues required NADPH and O2 for maximum activity and were inhibited by cytochrome c, SKF 525-A, and CO.	Oxygen	51-53	cytochrome c	Oryctolagus cuniculus	97-109
7315177-5	1981	Changes in myocardial oxygen consumption induced by combined thoracic epidural analgesia (T3-4 to L1-2) and light general anaesthesia with nitrous oxide and fentanyl were poorly correlated with changes in rate pressure product or triple product.	Oxygen	22-28	LINE1 retrotransposable element 1	Homo sapiens	98-102
827230-9	1976	Catalase did not affect the rates of heme decomposition and NADPH oxidation, but reduced the rate of O2 consumption by about 30%.	Oxygen	101-103	catalase	Sus scrofa	0-8
33869301-4	2021	Results: For the prediction of an impaired peak oxygen uptake (VO2) of < 14 mL/kg/min, receiver-operating characteristic curve demonstrated that the cutoff value of CAVI was 8.9.	Oxygen	48-54	carbonic anhydrase 6	Homo sapiens	165-169
33620066-6	2021	A decrease in LC3B concentration <5.5 ng/ml increased the risk of oxygen and ventilatory requirement (adjusted odds ratio: 4.6; 95% CI: 1.1-22.0; P = 0.04).	Oxygen	66-72	microtubule associated protein 1 light chain 3 beta	Homo sapiens	14-18
33620066-9	2021	COVID-19 patients with a decrease in LC3B concentration <5.5 ng/ml will require early hospital admission for supplemental oxygen therapy and other respiratory support.	Oxygen	122-128	microtubule associated protein 1 light chain 3 beta	Homo sapiens	37-41
7236254-0	1981	An oxygen-18 tracer investigation of the mechanism of myo-inositol oxygenase.	Oxygen	3-9	myo-inositol oxygenase	Homo sapiens	58-76
33689308-1	2021	OptoPB is an optogenetic tool engineered by fusion of the phosphoinositide (PI)-binding polybasic domain of Rit1 (Rit-PB) to a photoreactive light-oxygen-voltage (LOV) domain.	Oxygen	147-153	Ras like without CAAX 1	Homo sapiens	108-112
33499656-9	2021	Inducible enhancement of the Kvbeta1:Kvbeta2 ratio in Kv1 channels of arterial smooth muscle abolished L-lactate-induced vasodilation and suppressed the relationship between MBF and cardiac workload.Conclusions: The Kvbeta proteins differentially regulate vascular tone and myocardial blood flow, whereby Kvbeta2 promotes and Kvbeta1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand.	Oxygen	345-351	potassium voltage-gated channel, shaker-related subfamily, beta member 1	Mus musculus	29-36
33499656-9	2021	Inducible enhancement of the Kvbeta1:Kvbeta2 ratio in Kv1 channels of arterial smooth muscle abolished L-lactate-induced vasodilation and suppressed the relationship between MBF and cardiac workload.Conclusions: The Kvbeta proteins differentially regulate vascular tone and myocardial blood flow, whereby Kvbeta2 promotes and Kvbeta1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand.	Oxygen	345-351	potassium voltage-gated channel, shaker-related subfamily, beta member 1	Mus musculus	326-335
33740813-4	2021	Mitochondrial functionalities were also altered in NEK1 KO cells, with phenotypes of reduced mitophagy, increased total mitochondria, elevated levels of reactive oxygen species, impaired complex I activity, and higher amounts of mitochondrial DNA damage.	Oxygen	162-168	NIMA related kinase 1	Homo sapiens	51-55
1268310-0	1976	[Effects of arginine and growth hormone, administered in vivo and in vitro, on the oxygen consumption of rat liver hemogenates].	Oxygen	83-89	gonadotropin releasing hormone receptor	Rattus norvegicus	25-39
1246049-4	1976	The inactivation of COMT by these agents could be prevented by including an antioxidant in the preincubation mixture or by excluding oxygen; however, catalase did not protect the enzyme from inactivation.	Oxygen	133-139	catechol-O-methyltransferase	Homo sapiens	20-24
1238108-14	1975	The above findings help to explain the remarkably high oxygen affinity and some other ligand-binding properties of leghemoglobins which differ from those of myoglobin.	Oxygen	55-61	myoglobin	Physeter catodon	157-166
6257420-9	1981	We conclude that: fetal-placental ACE activity exhibits a chronically reduced level of activity appropriate to the low oxygen tension found in the fetal-placental unit; the placenta is the primary site of ACE activity in the fetus; maternal oxygenation modulates fetal-placental ACE activity; and fetal ACE activity acutely increases with increased fetal oxygenation and thus may play an important physiological role in the regulation of circulating levels of BK and AII and the circulatory adjustments at birth.	Oxygen	119-125	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	34-37
1165247-5	1975	Reoxidation of reduced cytochrome P-450 by molecular oxygen restores a state where 2 electrons from dithionite are required for re-reduction.	Oxygen	53-59	cytochrome P-450	Oryctolagus cuniculus	23-39
7204094-4	1981	HMW Hb has an increased oxygen affinity and a decreased Hill constant.	Oxygen	24-30	cilia and flagella associated protein 97	Homo sapiens	0-3
33841658-8	2021	Moreover, explants cultured with 10 ng/ml TGF-beta1 under hypoxic (1% O2) in combination with a bioreactor, significantly enhanced the expression of aggrecan and type II collagen, but were lacking in the production of Glycosaminoglycans (GAGs), as evidenced by alcian blue staining.	Oxygen	70-72	transforming growth factor beta 1	Sus scrofa	42-51
7204094-9	1981	The HMW Hb contributes to the inhibition of sickling resulting from treatment of sickle erythrocyte with MAI by increasing both MGC and oxygen affinity of the modified Hb.	Oxygen	136-142	cilia and flagella associated protein 97	Homo sapiens	4-7
33536256-3	2021	Truncation mutation in the FATC domain (R3047X) selectively compromised reactive oxygen species-induced ATM activation in cell-free assays.	Oxygen	81-87	ataxia telangiectasia mutated	Mus musculus	104-107
1212242-0	1975	The effect of chlorpromazine and of oxygen on the substrate-inhibition of L-amino acid oxidase.	Oxygen	36-42	interleukin 4 induced 1	Homo sapiens	74-94
7452615-0	1981	Stimulation by hCG in vivo of oxygen consumption by rabbit oocytes in vitro.	Oxygen	30-36	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
33264752-5	2021	The sensing mechanism of the sensor relies on the reaction of ethanol vapor and chemisorbed oxygen species in which the reaction rate increases due to an abundance of the chemisorbed oxygen within n-p heterojunctions of SnO2-rGO.	Oxygen	92-98	strawberry notch homolog 1	Homo sapiens	220-223
33264752-5	2021	The sensing mechanism of the sensor relies on the reaction of ethanol vapor and chemisorbed oxygen species in which the reaction rate increases due to an abundance of the chemisorbed oxygen within n-p heterojunctions of SnO2-rGO.	Oxygen	183-189	strawberry notch homolog 1	Homo sapiens	220-223
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	100-106	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	158-162
6448633-1	1980	During the hydrolysis of MgATP catalyzed by myosin, ATP bound to the protein undergoes a reaction such that the beta-nonbridge oxygen atoms exchange position with the beta gamma-bridge oxygen atom.	Oxygen	127-133	ATPase phospholipid transporting 8A2	Homo sapiens	27-30
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	100-106	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	192-196
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	100-106	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	192-196
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	163-169	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	158-162
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	163-169	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	192-196
28309234-2	1975	New equivalents are calculated for protein respiration.The energy equivalent for converting rate of oxygen consumption into rate of heat production (Q ox cal mg-1 oxygen consumed) is 3.53 cal mg-1 for carbohydrate oxidation, 3.28 cal mg-1 (range 3.22-3.32) for fat oxidation.	Oxygen	163-169	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	192-196
28309234-4	1975	The energy equivalent for converting rate of oxygen consumption into rate of energy loss in excreta (Q ex cal mg-1) varies considerably with different excretory products.	Oxygen	45-51	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	110-114
1201209-0	1975	The oxygen affinity of haemoglobin E.	Oxygen	4-10	hemoglobin subunit epsilon 1	Homo sapiens	23-36
1201209-1	1975	Oxygen dissociation studies were carried out on haemoglobin E (Hb E) at both high and low haemoglobin concentrations.	Oxygen	0-6	hemoglobin subunit epsilon 1	Homo sapiens	48-61
1201209-1	1975	Oxygen dissociation studies were carried out on haemoglobin E (Hb E) at both high and low haemoglobin concentrations.	Oxygen	0-6	hemoglobin subunit epsilon 1	Homo sapiens	63-67
1201209-2	1975	Oxygen affinities of fresh red cells from three people homozygous for Hb E and from one with Hb E-beta thalassaemia (Hb-E trait/beta-thal trait) were low in three out of four patients studied, while the oxygen affinity of red cells from an individual with Hb-E was normal 2,3-DPG concentration in the fresh cells from the people with homozygous Hb E or Hb-E trait/beta-thal trait which showed low oxygen affinities were elevated sufficiently to account for the shifts observed.	Oxygen	0-6	hemoglobin subunit epsilon 1	Homo sapiens	70-74
1201209-2	1975	Oxygen affinities of fresh red cells from three people homozygous for Hb E and from one with Hb E-beta thalassaemia (Hb-E trait/beta-thal trait) were low in three out of four patients studied, while the oxygen affinity of red cells from an individual with Hb-E was normal 2,3-DPG concentration in the fresh cells from the people with homozygous Hb E or Hb-E trait/beta-thal trait which showed low oxygen affinities were elevated sufficiently to account for the shifts observed.	Oxygen	0-6	hemoglobin subunit epsilon 1	Homo sapiens	93-97
33713713-5	2021	Furthermore, HO2 /O2 - was helpful in removing anthracene and fluoranthene.	Oxygen	18-22	heme oxygenase 2	Homo sapiens	13-16
33683823-6	2021	We found that lower oxygen and glucose concentrations enhance the expression of mesodermal (Brachyury, KIF1A) and ectodermal (Nestin, beta-Tubulin) markers.	Oxygen	20-26	T-box transcription factor 1	Homo sapiens	92-101
33754023-14	2021	Activating PPARalpha with WY14643 in primarily cultured Rap1-/- cardiomyocytes restored maximal oxygen consumption rates.	Oxygen	96-102	RAS-related protein 1a	Mus musculus	56-60
33850635-0	2021	PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1alpha.	Oxygen	80-86	prostate cancer associated transcript 1	Homo sapiens	0-6
6448633-1	1980	During the hydrolysis of MgATP catalyzed by myosin, ATP bound to the protein undergoes a reaction such that the beta-nonbridge oxygen atoms exchange position with the beta gamma-bridge oxygen atom.	Oxygen	185-191	ATPase phospholipid transporting 8A2	Homo sapiens	27-30
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	prostate cancer associated transcript 1	Homo sapiens	17-23
16345620-1	1980	During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism.	Oxygen	132-138	MS	Homo sapiens	52-56
33608066-9	2021	H19 overexpression in oxygen-glucose deprivation neurons increased B-cell lymphoma-2 and decreased B-cell lymphoma-2-associated X, total and cleaved caspase-3 expressions.	Oxygen	22-28	caspase 3	Rattus norvegicus	149-158
4530280-5	1974	The differential effect on oxygen consumption may result from the absence of asparagine synthetase in sensitive cells.	Oxygen	27-33	asparagine synthetase	Mus musculus	77-98
6778524-10	1980	When enzyme uptake by liver was inhibited by injection of ovomucoid or mannans, however, the hyperbaric oxygen-induced apparent uptake of beta-hexosaminidase by brain, cerebellum, and spinal cord was 200-500 U/gr of blood-free tissue, suggesting that the transport mechanism involved (presumably at the level of the nervous system vascular endothelium) is different from the carbohydrate-dependent hepatic uptake.	Oxygen	104-110	O-GlcNAcase	Homo sapiens	138-157
4603315-0	1974	[Actions of growth hormone, norethandrolone and their combination on the oxygen consumption of rat liver homogenates].	Oxygen	73-79	gonadotropin releasing hormone receptor	Rattus norvegicus	12-26
11826889-2	1970	Fat is most efficient because it has a higher ratio of carbon and hydrogen to oxygen than do protein and carbohydrate, so stored food systems for long missions would logically rely heavily on this form of calories.	Oxygen	78-84	FAT atypical cadherin 1	Homo sapiens	0-3
33404366-4	2021	Here, we introduce cellular clock biology as a novel mechanism linking early oxygen exposure to airway biology.	Oxygen	77-83	clock circadian regulator	Homo sapiens	28-33
33404366-7	2021	We hypothesized that hyperoxia impacts clock function in fASM and that the clock can be leveraged to attenuate deleterious effects of O2 on the developing airway.	Oxygen	134-136	clock circadian regulator	Homo sapiens	75-80
33404366-8	2021	We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2.	Oxygen	145-147	clock circadian regulator	Homo sapiens	39-44
33404366-8	2021	We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2.	Oxygen	145-147	clock circadian regulator	Homo sapiens	87-92
158596-2	1979	ATP concentration modulates oxygen exchange catalyzed by purified, soluble mitochondrial ATPase during ATP hydrolysis so that water oxygen incorporation into each Pi formed increases markedly as ATP concentration is lowered.	Oxygen	28-34	ATP synthase F1 subunit epsilon	Homo sapiens	75-95
33404366-10	2021	Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1.	Oxygen	11-13	clock circadian regulator	Homo sapiens	62-67
33404366-10	2021	Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1.	Oxygen	11-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
5511483-0	1970	[Effect of serum albumin on oxygen consumption and introduction of lysine-I-Cl4 into erythrocytes of chickens].	Oxygen	28-34	albumin	Gallus gallus	11-24
231005-2	1979	Nutrient medium, oxygen tension and Gelfoam support matrix influence the synthesis of hCG by these cultures.	Oxygen	17-23	hypertrichosis 2 (generalised, congenital)	Homo sapiens	86-89
14026502-0	1963	[Effect of fat infusions on the performance, blood supply and oxygen consumption of the isolated perfused heart].	Oxygen	62-68	FAT atypical cadherin 1	Homo sapiens	11-14
14031389-0	1962	The source of oxygen in the phenylalanine hydroxylase and the copamine-beta-hydroxylase catalyzed rections.	Oxygen	14-20	phenylalanine hydroxylase	Homo sapiens	28-53
31875691-10	2021	(2) Apoptosis, reactive oxygen species content, and malondialdehyde levels were increased when Prdx6 was downregulated.	Oxygen	24-30	peroxiredoxin 6	Homo sapiens	95-100
27230-10	1978	A slight, but definite increase in oxygen affinity was observed for Hb A2 as well as for Hb P-Nilotic while the increase for the Hb Lepore-Washington was somewhat greater.	Oxygen	35-41	hemoglobin subunit alpha 2	Homo sapiens	68-73
32978975-0	2021	Low Oxygen Tension Differentially Regulates the Expression of Placental Solute Carriers and ABC Transporters.	Oxygen	4-10	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	92-95
32978975-2	2021	Here, we compared the ability of low oxygen tension to alter the expression of solute carriers (SLC) and ABC transporters in two human placental models, namely BeWo cells and term placental explants.	Oxygen	37-43	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	105-108
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	143-147
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier family 22 member 5	Homo sapiens	158-163
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier family 22 member 9	Homo sapiens	208-212
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	sterol O-acyltransferase 1	Homo sapiens	229-233
33094721-7	2021	Additionally, the apnea-hypopnea index was lower (p=0.001), and the lowest oxygen saturation was significantly higher in the Epi group (p=0.042).	Oxygen	75-81	tissue factor pathway inhibitor	Homo sapiens	125-128
13304204-0	1956	The Pauling oxygen analyser as an aid to the anaesthetist.	Oxygen	12-18	activation induced cytidine deaminase	Homo sapiens	34-37
33951411-7	2021	MSCs preconditioning with ghrelin restored IR-induced mitochondrial reactive oxygen species and membrane potential depolarization and enhanced ATP production.	Oxygen	77-83	ghrelin and obestatin prepropeptide	Rattus norvegicus	26-33
33631320-8	2021	In contrast, reduced mitochondrial ATP generation and oxygen consumption rates observed in TOP3A defective cells were rescued by over-expression of the wildtype TOP3A, but not TOP3A-D479G.	Oxygen	54-60	DNA topoisomerase III alpha	Homo sapiens	91-96
33631320-8	2021	In contrast, reduced mitochondrial ATP generation and oxygen consumption rates observed in TOP3A defective cells were rescued by over-expression of the wildtype TOP3A, but not TOP3A-D479G.	Oxygen	54-60	DNA topoisomerase III alpha	Homo sapiens	161-166
669574-5	1978	The earlier finding that the O2 affinity of the llama hemoglobin is dependent on its content of 2, 3-bisphosphoglycerate is interpreted here as a mutation of the 2, 3-bisphosphoglycerate contact position beta2 His in human hemoglobin to beta2 Asn in llama hemoglobin, whereby one of the four 2, 3-bisphosphoglycerate contact points is interrupted.	Oxygen	29-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	204-209
33631320-8	2021	In contrast, reduced mitochondrial ATP generation and oxygen consumption rates observed in TOP3A defective cells were rescued by over-expression of the wildtype TOP3A, but not TOP3A-D479G.	Oxygen	54-60	DNA topoisomerase III alpha	Homo sapiens	161-166
33127052-0	2021	Enriched oxygen vacancies of Cu2O/SnS2/SnO2 heterostructure for enhanced photocatalytic reduction of CO2 by water and nitrogen fixation.	Oxygen	9-15	sodium voltage-gated channel alpha subunit 11	Homo sapiens	34-38
669574-5	1978	The earlier finding that the O2 affinity of the llama hemoglobin is dependent on its content of 2, 3-bisphosphoglycerate is interpreted here as a mutation of the 2, 3-bisphosphoglycerate contact position beta2 His in human hemoglobin to beta2 Asn in llama hemoglobin, whereby one of the four 2, 3-bisphosphoglycerate contact points is interrupted.	Oxygen	29-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	237-242
33639987-9	2021	In vitro study elucidated that Notch 2 participated in the activation of ACE system and angiotensin II release, induced by midkine and triggered vascular endothelial injury by angiotensin II induced reactive oxygen species production.	Oxygen	208-214	notch 2	Mus musculus	31-38
33639987-9	2021	In vitro study elucidated that Notch 2 participated in the activation of ACE system and angiotensin II release, induced by midkine and triggered vascular endothelial injury by angiotensin II induced reactive oxygen species production.	Oxygen	208-214	midkine	Mus musculus	123-130
33217156-0	2021	Hb Angers: A new alpha2-globin variant [alpha2 (140)(HC2) Tyr   Ser; HBA2: C.422 A>C] with increased oxygen affinity leading to erythrocytosis.	Oxygen	101-107	hemoglobin subunit alpha 2	Homo sapiens	17-30
33217156-0	2021	Hb Angers: A new alpha2-globin variant [alpha2 (140)(HC2) Tyr   Ser; HBA2: C.422 A>C] with increased oxygen affinity leading to erythrocytosis.	Oxygen	101-107	hemoglobin subunit alpha 2	Homo sapiens	69-73
566480-1	1978	Using three independent methods tte amperometric titration, Boyer"s method and the method of Ellman it is shown that rabbit muscle creatine kinase contains 11-12 SH-groups, 3-6 of which are easily oxidized by atmospheric oxygen to form S-S-bonds.	Oxygen	221-227	creatine kinase M-type	Oryctolagus cuniculus	124-146
34059808-6	2021	18O- and 2H-labelling studies evidence the direct evolution of O2 through the nucleophilic attack of a H2O molecule on the highly electrophilic metal-oxo species via the formation of eta2-1iv-OO.	Oxygen	63-65	DNA polymerase iota	Homo sapiens	183-187
33652868-3	2021	The permanent porosity of 1 was confirmed by N2, O2, CO, CO2, CH4 adsorption measurements at various temperatures (77 K, 273 K, 298 K), resulted in BET surface area 667 m2 g-1 and promising gas separation performance with selectivity factors up to 35.7 for CO2/N2, 45.4 for CO2/O2, 20.8 for CO2/CO, and 4.8 for CO2/CH4.	Oxygen	49-51	delta/notch like EGF repeat containing	Homo sapiens	148-151
33652868-3	2021	The permanent porosity of 1 was confirmed by N2, O2, CO, CO2, CH4 adsorption measurements at various temperatures (77 K, 273 K, 298 K), resulted in BET surface area 667 m2 g-1 and promising gas separation performance with selectivity factors up to 35.7 for CO2/N2, 45.4 for CO2/O2, 20.8 for CO2/CO, and 4.8 for CO2/CH4.	Oxygen	58-60	delta/notch like EGF repeat containing	Homo sapiens	148-151
18351-3	1977	The results suggest that Mg2+ binds simultaneously to one (or both) of the two free oxygen atoms of the beta-phosphate moiety and to the nitrogen atom of the phosphate chain (P alpha-O-P beta-N-P gamma).	Oxygen	84-90	mucin 7, secreted	Homo sapiens	25-28
33560846-1	2021	In low-temperature flash photolysis of NH3/O2/N2 mixtures, the NH2 consumption rate and the product distribution is controlled by the reactions NH2 + HO2   products (R1), NH2 + H (+M)   NH3 (+M) (R2), and NH2 + NH2 (+M)   N2H4 (+M) (R3).	Oxygen	43-45	heme oxygenase 2	Homo sapiens	150-153
33904834-10	2021	Overall, our results suggest that IRE1alpha and eIF2alpha UPR-pathways are differentially regulated by oxygen and insulin in early pregnancy.	Oxygen	103-109	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	34-43
34042257-7	2021	What is more, knockdown of ZNF479 inhibited glucose uptake, lactate production, adenosine triphosphate level, and extracellular acidification ratio; increased oxygen consumption ratio in gastric cancer cells; and decreased the expression of glycolytic proteins both in vitro and in vivo.	Oxygen	159-165	zinc finger protein 479	Homo sapiens	27-33
21126-2	1977	MAO activity in rat brain mitochondria with tyramine as substrate at 100% oxygen concentration was three times as much as that at 20%.	Oxygen	74-80	monoamine oxidase A	Rattus norvegicus	0-3
34052625-5	2021	In contrast, moderate hypoxia (5% O2) upregulates osteopontin expression via activation of HIF-2alpha.	Oxygen	34-36	secreted phosphoprotein 1	Mus musculus	50-61
34029065-1	2021	On reacting laser-ablated manganese or iron difluorides with O2 or O3 during codeposition in solid neon or argon, infrared absorptions of several new metal oxo-fluoride molecules, including OMF2, (eta1-O2)MF2, (eta2-O3)MF2, (eta1-O2)2MF2 (M = Mn and Fe), and O2MnF, have been observed.	Oxygen	61-63	DNA polymerase iota	Homo sapiens	211-215
33622439-9	2021	In contrast, the expression levels of MAPK14 and CPT2 genes were increased (P <= 0.05) in groups of oocytes cultured under low compared with high oxygen tension that was subsequently associated with increased mitochondrial activity.	Oxygen	146-152	carnitine palmitoyltransferase 2	Homo sapiens	49-53
33622439-11	2021	However, low-quality oocytes (BCB-) responded negatively to high oxygen tension by reducing the expression of gene-regulating metabolic activity (CPT2).	Oxygen	65-71	carnitine palmitoyltransferase 2	Homo sapiens	146-150
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	Oxygen	330-336	Glycerophosphate oxidase 1	Drosophila melanogaster	228-235
34031767-11	2021	Expressions of BNIP3, ENO1, GAPDH, and SLC2A1, were upregulated in 7% oxygen/low glucose, compared to 20% oxygen groups.	Oxygen	70-76	solute carrier family 2 member 1	Bos taurus	39-45
13968-3	1977	In nine patients with periodic studies of arterial blood, the mean change in arterial oxygen pressure from base line was a decrease of 0.8 mm Hg at ten minutes into therapy, 2.8 mm Hg at the conclusion of therapy, and 2.9 mm Hg 20 minutes after therapy.	Oxygen	86-92	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	225-230
34027895-2	2021	Oxygen tension is an environmental cue that distinguishes peripheral tissues from the circulation, and here, we demonstrate that differentiation of human CD8+ T cells in the presence of hypoxia and TGF-beta1 led to the development of a TRM phenotype, characterized by a greater than 5-fold increase in CD69+CD103+ cells expressing human TRM hallmarks and enrichment for endogenous human TRM gene signatures, including increased adhesion molecule expression and decreased expression of genes involved in recirculation.	Oxygen	0-6	CD69 molecule	Homo sapiens	302-306
33608602-4	2021	In response to acute lung injury, ATM-deficiency causes decreased survival, reduced blood oxygen saturation, elevated neutrophil recruitment, exaggerated and prolonged inflammatory responses and excessive lung injury compared to controls.	Oxygen	90-96	ataxia telangiectasia mutated	Mus musculus	34-37
188820-12	1977	The EPR spectrum of the oxy alpha chain showed a distinctly narrowed hyperfine structure in comparison with that of the oxy beta chain, indicating that the environment around the paramagnetic center (the bound oxygen) is different between these chains.	Oxygen	210-216	TNF alpha induced protein 8 like 1	Homo sapiens	120-128
33670592-3	2021	After 10 days of blue light exposure, increased reactive oxygen species and malondialdehyde were observed in the WT + BL and NOD2-KO + BL groups, and the WT + BL group showed a higher expression of NOD2 and autophagy related 16 like 1.	Oxygen	57-63	nucleotide-binding oligomerization domain containing 2	Mus musculus	125-129
33472844-0	2021	Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.	Oxygen	0-6	ras homolog family member A	Mus musculus	56-60
33472844-0	2021	Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.	Oxygen	0-6	yes-associated protein 1	Mus musculus	72-75
34003633-5	2021	For each Mo site, the initial turnover frequency (TOF0) for oxygen atom transfer from ClOx- substrates reached 165 h-1.	Oxygen	60-66	cut like homeobox 1	Homo sapiens	86-90
34034080-0	2021	Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis.	Oxygen	37-43	selenoprotein S	Gallus gallus	9-24
14738-3	1977	After 30 min in a 12% oxygen environment there were significant reductions of tyrosine hydroxylase and tryptophan hydroxylase activity at 1,14 and 28 but not 4 days of postnatal age.	Oxygen	22-28	tyrosine hydroxylase	Rattus norvegicus	78-98
34001853-3	2021	Further analysis indicated that mitochondrial superoxide dismutase (SOD)2, which converts O2- into H2O2 remained deacetylated in CLL cells due to SIRT3 overexpression resulting its constitutive activation.	Oxygen	90-93	superoxide dismutase 2	Homo sapiens	46-73
33507746-6	2021	The distribution of trap depths is continuous according to the analysis of thermoluminescence (TL) spectra using the initial rising method, which relates to the random distribution of Mg2+ and Sn4+ at the second coordination sphere of the Cr3+ centers rather than the oxygen-related defects.	Oxygen	268-274	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	239-242
264675-1	1977	Oxygen uptake of fully deoxygenated sickle (SS) erythrocytes is slower than that of normal (AA) erythrocytes, as demonstrated by the half-times of the overall oxygenation reactions: at 25 degrees in an isotonic phosphate buffer the normal red cells have a t1/2 = 82 +/- 4.7 msec, as compared to sickle red cells where t1/2 = 135 +/- 17.6 msec.	Oxygen	0-6	interleukin 1 receptor like 1	Homo sapiens	318-328
33268062-8	2021	An electron transfer of the Mn species facilitated the decomposition of PS to generate HO2 /O2  - radicals, which were utilized as a precursor for 1O2 generation via direct oxidation or the recombination of HO2 /O2  -.	Oxygen	92-97	heme oxygenase 2	Homo sapiens	87-90
33268062-8	2021	An electron transfer of the Mn species facilitated the decomposition of PS to generate HO2 /O2  - radicals, which were utilized as a precursor for 1O2 generation via direct oxidation or the recombination of HO2 /O2  -.	Oxygen	92-97	heme oxygenase 2	Homo sapiens	207-210
33268062-8	2021	An electron transfer of the Mn species facilitated the decomposition of PS to generate HO2 /O2  - radicals, which were utilized as a precursor for 1O2 generation via direct oxidation or the recombination of HO2 /O2  -.	Oxygen	212-217	heme oxygenase 2	Homo sapiens	87-90
33957043-6	2021	Electrochemical results indicate that the as-prepared Co-SAs-HCS catalyst shows a low potential difference (0.809 V) between the oxygen evolution reaction potential at 10 mA cm-2 and the oxygen reduction reaction half-wave potential, outperforming the commercial Pt/C catalysts (0.996 V).	Oxygen	129-135	holocarboxylase synthetase	Homo sapiens	61-64
33957043-6	2021	Electrochemical results indicate that the as-prepared Co-SAs-HCS catalyst shows a low potential difference (0.809 V) between the oxygen evolution reaction potential at 10 mA cm-2 and the oxygen reduction reaction half-wave potential, outperforming the commercial Pt/C catalysts (0.996 V).	Oxygen	187-193	holocarboxylase synthetase	Homo sapiens	61-64
33979990-2	2021	A compelling model posits that - at high oxygen saturation - the N-term cytosolic domain of AE1 binds to and inhibits glycolytic enzymes, thus diverting metabolic fluxes to the pentose phosphate pathway to generate reducing equivalents.	Oxygen	41-47	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	92-95
33580152-7	2021	Furthermore, alterations of intracellular Ca2+, reactive oxygen species, mitochondrial function, and lactate levels were observed in amylin-treated cells.	Oxygen	57-63	islet amyloid polypeptide	Homo sapiens	133-139
33547244-6	2021	Cerebella of IP6K2-deleted mice (IP6K2-knockout [KO]) produced less phosphocreatine and ATP and generated higher levels of reactive oxygen species and protein oxidative damage.	Oxygen	132-138	inositol hexaphosphate kinase 2	Mus musculus	13-18
33547244-6	2021	Cerebella of IP6K2-deleted mice (IP6K2-knockout [KO]) produced less phosphocreatine and ATP and generated higher levels of reactive oxygen species and protein oxidative damage.	Oxygen	132-138	inositol hexaphosphate kinase 2	Mus musculus	33-38
33978488-2	2021	For the first problem increased hemoglobin oxygen affinity (left shift of the oxygen dissociation curve ODC) is of advantage, for the 2nd, however, the contrary is the case.	Oxygen	43-49	ornithine decarboxylase 1	Homo sapiens	104-107
33978488-2	2021	For the first problem increased hemoglobin oxygen affinity (left shift of the oxygen dissociation curve ODC) is of advantage, for the 2nd, however, the contrary is the case.	Oxygen	78-84	ornithine decarboxylase 1	Homo sapiens	104-107
791990-0	1976	UDPgalactose 4-epimerase catalyzed oxygen dependent reduction of a free radical substrate analogue by two electron reducing agents.	Oxygen	35-41	UDP-galactose-4-epimerase	Homo sapiens	0-24
34054950-2	2021	The aim of this study was to explore the expression of UCA1 in hypoxic breast cancer and its impact on tumorigenesis in low levels of oxygen.	Oxygen	134-140	urothelial cancer associated 1	Homo sapiens	55-59
34054950-3	2021	Here, we show that UCA1 is upregulated in a number of hypoxic (1% O2) breast cancer cells.	Oxygen	66-68	urothelial cancer associated 1	Homo sapiens	19-23
33955709-10	2021	From in vivo and ex vivo experiments, Tfr1 deletion in SCs results in an irreversible depletion of SCs (~60% reduction, P < 0.005) and cell-autonomous defect in SC proliferation and differentiation, leading to skeletal muscle regeneration impairment, followed by labile iron accumulation, lipogenesis, and decreased Gpx4 and Nrf2 protein levels leading to reactive oxygen species scavenger defects.	Oxygen	365-371	transferrin receptor	Mus musculus	38-42
33554327-7	2021	Oxygen exposure for either 20 or 60 min resulted in significantly decreased plasma vascular endothelial growth factor levels at 3 h, whereas oxygen exposure for only 60 min reduced plasma insulin-like growth factor 1 levels at 24 h (p < .05 vs. control).	Oxygen	141-147	insulin-like growth factor 1	Mus musculus	188-216
33554327-8	2021	Protein array indicated the increase in the levels of some cytokines/chemokines, such as CXCL6 (GCP-2) at 24 h after 60 min of oxygen exposure.	Oxygen	127-133	chemokine (C-X-C motif) ligand 5	Mus musculus	89-94
33554327-8	2021	Protein array indicated the increase in the levels of some cytokines/chemokines, such as CXCL6 (GCP-2) at 24 h after 60 min of oxygen exposure.	Oxygen	127-133	chemokine (C-X-C motif) ligand 5	Mus musculus	96-101
33554327-9	2021	Moreover, oxygen exposure for 60 min enhanced the recruitment of Ly6g- and CD11c-positive inflammatory cells at 3 days (p < .05 vs. control) and increased the fibrotic area at 14 days in the heart after I/R injury (p < .05 vs. control).	Oxygen	10-16	integrin subunit alpha X	Homo sapiens	75-80
10958-3	1976	The oxygen dissociation curve measured at an extracellular pH of 7.4 demonstrated that PLP incorporated into the cells also lowered the oxygen affinity and that PLP functionally compensated for a metabolically reduced 2,3-DPG.	Oxygen	4-10	pyridoxal phosphatase	Homo sapiens	87-90
33562049-4	2021	In contrast, HVCN1-blocking with 2-GBI led to a significant decrease in post-thaw sperm quality as compared to the control, despite intracellular O2-- and H2O2 levels in 2-GBI blocked samples being lower than in the control and in TEA- and PAX-blocked samples.	Oxygen	146-149	hydrogen voltage gated channel 1	Sus scrofa	13-18
32249716-8	2021	Functional experiments show that the oxygen consumption rate and the glycolytic function of cells lacking MFN2 but not MFN1 are obviously attenuated, and MFN2 is important for cell survival under energy stress.	Oxygen	37-43	mitofusin 2	Mus musculus	106-110
10958-3	1976	The oxygen dissociation curve measured at an extracellular pH of 7.4 demonstrated that PLP incorporated into the cells also lowered the oxygen affinity and that PLP functionally compensated for a metabolically reduced 2,3-DPG.	Oxygen	136-142	pyridoxal phosphatase	Homo sapiens	87-90
33523764-6	2021	Compared to normoxia, hypoxia (0.2% O2) for 24 hr increased hypoxia inducible factor-1alpha-dependent NEDD9 upregulation in vitro.	Oxygen	36-38	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	102-107
10958-4	1976	However, the dependency of the oxygen affinity on the intracellular PLP concentration showed a different pattern from the observed for 2,3-DPG.	Oxygen	31-37	pyridoxal phosphatase	Homo sapiens	68-71
32638314-4	2021	This is due to the generation of photo-active reactive oxygen species (HO  and HO2 -/O2 -) under photolysis in STP effluent, as verified by experiments in the presence of 2-propanol and chloroform.	Oxygen	55-61	heme oxygenase 2	Homo sapiens	79-82
10958-6	1976	The peculiar relationship between the oxygen affinity of erythrocytes and the intracellular PLP concentration is discussed in detail.	Oxygen	38-44	pyridoxal phosphatase	Homo sapiens	92-95
33356402-5	2021	NOR-1 transgenesis amplifies the response to Ang II enhancing vascular inflammation (production of proinflammatory cytokines, chemokines, and reactive oxygen species), increasing MMP (matrix metalloproteinase) activity and disturbing elastin integrity, thereby broking the resistance of C57BL/6 mice to Ang II-induced AAA.	Oxygen	151-157	nuclear receptor subfamily 4, group A, member 3	Mus musculus	0-5
33835088-10	2021	RESULTS: Tissue oxygen saturation exhibited a strong negative correlation to distance from the flap pedicle (r = -0.798).	Oxygen	16-22	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	95-99
962863-2	1976	The turkey liver xanthine dehydrogenase-catalysed oxidation of NADH by Methylene Blue, by ferricyanide or by O2 is not dependent on the integrity of the active-centre persulphide groups.	Oxygen	109-111	xanthine dehydrogenase/oxidase	Meleagris gallopavo	17-39
34041450-5	2021	Further study showed Nrf2 regulated reactive-oxygen-species-mediated Hippo-yes-associated protein (YAP) signaling, which in turn modulated the NLRP3 inflammasome activation.	Oxygen	45-51	yes-associated protein 1	Mus musculus	69-97
34041450-5	2021	Further study showed Nrf2 regulated reactive-oxygen-species-mediated Hippo-yes-associated protein (YAP) signaling, which in turn modulated the NLRP3 inflammasome activation.	Oxygen	45-51	yes-associated protein 1	Mus musculus	99-102
33535693-7	2021	In mild OSA patients, there was a negative correlation between LOX-1 and mean arterial oxygen saturation during sleep.	Oxygen	87-93	oxidized low density lipoprotein receptor 1	Homo sapiens	63-68
956473-8	1976	The assay of catalase, which involved the measurement of the initial rate of release of O2 using an O2 analyser apparatus, was rapid, sensitive and reasonably reliable, if fresh milk samples were used.	Oxygen	88-90	catalase	Bos taurus	13-21
33030056-2	2021	In this work, we aimed to evaluate the association between TIM and maximal functional capacity assessed by the percentage of predicted peak exercise oxygen uptake (pp-peakVO2) in patients with heart failure and preserved ejection fraction (HFpEF).	Oxygen	149-155	Rho guanine nucleotide exchange factor 5	Homo sapiens	59-62
33501881-0	2021	CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway.	Oxygen	40-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	94-98
33574084-4	2021	Measuring protein phosphorylation and expression in glioblastoma cells across 40 signaling pathway nodes in response to different drugs and for different oxygen tensions revealed that SHP2 antagonism has network-level, context-dependent signaling consequences that affect cell phenotypes (e.g., cell death) in unanticipated ways.	Oxygen	154-160	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	184-188
33504837-5	2021	All tested salicylic diamines exerted their toxicity by inhibiting the oxygen consumption rate (OCR) in PSCs.	Oxygen	71-77	corneal susceptibility to P. aeruginosa	Mus musculus	104-108
33483548-3	2021	The goal of this exploratory study was to establish a technique to noninvasively characterize placental partial pressure of oxygen (PO2) in vivo in the Lgals1 (lectin, galactoside-binding, soluble, 1) deficient mouse model of preeclampsia using fluorine magnetic resonance imaging.	Oxygen	124-130	lectin, galactose binding, soluble 1	Mus musculus	152-158
956473-8	1976	The assay of catalase, which involved the measurement of the initial rate of release of O2 using an O2 analyser apparatus, was rapid, sensitive and reasonably reliable, if fresh milk samples were used.	Oxygen	100-102	catalase	Bos taurus	13-21
176939-0	1976	Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase.	Oxygen	63-65	xanthine dehydrogenase	Rattus norvegicus	104-126
33417765-5	2021	We demonstrated that the synergistic effect of multiple reactive species originated from tandem cascade reactions comprising reduction of O2 by H  to form O2 -/HO2  and downstream reaction of O2 - with  NO to yield ONOO-.	Oxygen	138-140	heme oxygenase 2	Homo sapiens	160-163
33417765-5	2021	We demonstrated that the synergistic effect of multiple reactive species originated from tandem cascade reactions comprising reduction of O2 by H  to form O2 -/HO2  and downstream reaction of O2 - with  NO to yield ONOO-.	Oxygen	155-157	heme oxygenase 2	Homo sapiens	160-163
33417765-5	2021	We demonstrated that the synergistic effect of multiple reactive species originated from tandem cascade reactions comprising reduction of O2 by H  to form O2 -/HO2  and downstream reaction of O2 - with  NO to yield ONOO-.	Oxygen	155-157	heme oxygenase 2	Homo sapiens	160-163
176940-0	1976	The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O).	Oxygen	107-109	xanthine dehydrogenase	Rattus norvegicus	41-63
33356196-4	2021	The Fe2O3 NPs@NiO NSs nanocomposite possessed a high BET surface area (194.1 m2 g-1), which is very conducive to the charge/mass transfer of electrolyte ions and O2.	Oxygen	162-164	delta/notch like EGF repeat containing	Homo sapiens	53-56
1013171-5	1976	Measurement of in vitro brain oxygen consumption indicated that mice treated with alpha-MSH exhibit an 18% reduction in respiration of the brain stem section which includes the locus coeruleus, but did not reliably change respiration in forebrain cortices.	Oxygen	30-36	pro-opiomelanocortin-alpha	Mus musculus	82-91
33510583-11	2021	Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-kappaB-dependent inflammatory response and protects SIRT1/PGC-1alpha-dependent mitochondrial function.	Oxygen	18-21	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	159-169
823735-1	1976	A partially purified soybean lipoxygenase (L-3) was incubated for 15 min at pH 6.5 with linoleic acid and oxygen.	Oxygen	32-38	seed linoleate 9S-lipoxygenase-3	Glycine max	43-46
33446609-4	2021	RESULTS: Individuals with ILA were usually males (p<0.005), older than controls (<0.0001), smokers (p=0.01), with greater frequency of MUC5B rs35705950 (OR 3.5; CI 95% 1.29-9.44, p=0.01), and reduced DLCO and oxygen saturation.	Oxygen	209-215	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	135-140
241106-1	1975	Rotating ring-disc electrode studies have indicated that relatively large quantities of hydrogen peroxide ion, HO2-, are produced when oxygen is reduced at a platinum or gold polarographic electrode surface.	Oxygen	135-141	heme oxygenase 2	Homo sapiens	111-114
1125427-11	1975	Oxygen affinity of both HN2 and Nor-HN2 treated human red cells remains virtually the same as that found in control samples.	Oxygen	0-6	MT-RNR2 like 2 (pseudogene)	Homo sapiens	24-27
33435504-4	2021	Transforming growth factor (TGF)-beta/P-Smad is a major pathway of fibrosis featured with epithelia mesenchymal transformations (EMT) and collagen depositions, accompanying with excessive oxygen-free radicals.	Oxygen	188-194	transforming growth factor alpha	Homo sapiens	0-37
1125427-11	1975	Oxygen affinity of both HN2 and Nor-HN2 treated human red cells remains virtually the same as that found in control samples.	Oxygen	0-6	MT-RNR2 like 2 (pseudogene)	Homo sapiens	36-39
33350421-0	2021	Defect-assisted electronic metal-support interactions: tuning the interplay between Ru nanoparticles and CuO supports for pH-neutral oxygen evolution.	Oxygen	133-139	phenylalanine hydroxylase	Homo sapiens	122-124
235982-17	1975	The kinetics of redox changes in cytochrome b, in the presence of antimycin and oxygen, are distinctly different in the mutant and wild-type particles.	Oxygen	80-86	cytochrome b	Saccharomyces cerevisiae S288C	33-45
33401635-6	2021	Oxygen content during process is also crucial because the hole-conductive p-type SnO channel is oxidized into oxygen-rich n-type SnO2 to demote the device performance.	Oxygen	0-6	strawberry notch homolog 1	Homo sapiens	81-84
235982-18	1975	They indicate that ubiquinone plays an important role in the phenomenon of the increased reducibility of cytochrome b induced by antimycin plus oxygen.	Oxygen	144-150	cytochrome b	Saccharomyces cerevisiae S288C	105-117
4146221-0	1973	Cytochrome c enhancement of singlet molecular oxygen production by the NADPH-dependent adrenodoxin reductase-adrenodoxin system: the role of singlet oxygen in damaging adrenal mitochondrial membranes.	Oxygen	46-52	ferredoxin reductase	Homo sapiens	87-108
33168191-9	2021	The potential of PGAM1 suppression to inhibit inflammatory response, apoptosis and fibrosis were verified in the isolated cardiomyocytes and fibroblasts treated with oxygen-glucose deprivation reperfusion (OGDR) and TGF-beta, respectively.	Oxygen	166-172	phosphoglycerate mutase 1	Mus musculus	17-22
4675876-0	1972	Kinetics of carbon monoxide and oxygen binding for eight electrophoretic components of sperm-whale myoglobin.	Oxygen	32-38	myoglobin	Physeter catodon	99-108
32727333-2	2021	Insufficient oxygen and glucose supply caused by cerebral ischemia leads to higher ratio of AMP/ATP, which will activate AMPK pathway to initiate the process of autophagy.	Oxygen	13-19	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	121-125
33140223-1	2021	Generation of nitric oxide (NO) by the nitric oxide synthase (NOS) enzymes plays multiple signalling roles in every organ system, with crucial roles in the cardiovascular system, mediated by endothelial nitric oxide synthase (eNOS, encoded by NOS3) and neuronal nitric oxide synthase (nNOS, encoded by NOS1) in regulation of blood pressure, flow, oxygen delivery and cardiac function.	Oxygen	347-353	nitric oxide synthase 1	Homo sapiens	39-60
4927597-1	1970	Refinements of the anaerobic technique such as the utilization of prereduced media and the removal of traces of oxygen from the gases used by passage through a hot copper oven resulted in quantitative and qualitative improvements in the recovery of anaerobic bacteria from the cecum of SPF mice.	Oxygen	112-118	SEC14-like lipid binding 4	Mus musculus	286-289
33478272-0	2021	Hb Waikato [alpha127(H10)Lys Gln; HBA1: c.382A>C]: A Novel High Oxygen Affinity Variant.	Oxygen	64-70	hemoglobin subunit alpha 1	Homo sapiens	34-38
33478272-1	2021	We report the identification of a novel, high oxygen affinity hemoglobin (Hb) variant [alpha127(H10)Lys Gln; HBA1: c.382A>C].	Oxygen	46-52	hemoglobin subunit alpha 1	Homo sapiens	109-113
33643804-3	2021	Herein, an oxygen-enriched X-ray nanoprocessor Hb@Hf-Ce6 nanoparticle is developed for improving the therapeutic effect of RT-radiodynamic therapy (RDT), enhancing modulation of hypoxia tumor microenvironment (TME) and promoting antitumor immune response in combination with programmed cell death protein 1 (PD-1) immune checkpoint blockade.	Oxygen	11-17	programmed cell death 1	Homo sapiens	275-306
33643804-3	2021	Herein, an oxygen-enriched X-ray nanoprocessor Hb@Hf-Ce6 nanoparticle is developed for improving the therapeutic effect of RT-radiodynamic therapy (RDT), enhancing modulation of hypoxia tumor microenvironment (TME) and promoting antitumor immune response in combination with programmed cell death protein 1 (PD-1) immune checkpoint blockade.	Oxygen	11-17	programmed cell death 1	Homo sapiens	308-312
33375614-2	2020	This work analyses the effect of ageing the same red wine in barrels with different oxygenation rates for one year (OTR), specifically the effect on the evolution of anthocyanins, their derivatives and the appearance of new pigments according to the oxygen dosage in barrels.	Oxygen	84-90	oxytocin receptor	Homo sapiens	116-119
33336311-5	2020	The aim of this review was to describe the pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest.According to our findings, the optimal ventilator strategies in post cardiac arrest patients are not fully understood, and oxygen and carbon dioxide targets should take in consideration a complex pattern of pathophysiological factors.	Oxygen	260-266	phenylalanine hydroxylase	Homo sapiens	113-115
4241910-6	1969	Apparently an ATPase is activated by depolarization; the resulting ADP is probably the trigger for the increase in oxygen uptake.3.	Oxygen	115-121	dynein axonemal heavy chain 8	Homo sapiens	14-20
14188726-16	1964	Oxygen consumption by B. subtilis was actually stimulated by highly purified rabbit transferrin.	Oxygen	0-6	serotransferrin	Oryctolagus cuniculus	84-95
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	aquaporin 1	Rattus norvegicus	278-282
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	cadherin 5	Rattus norvegicus	352-363
13860737-0	1961	[Respiratory exercises under oxygen as an aid in rehabilitation of surgical patients].	Oxygen	29-35	activation induced cytidine deaminase	Homo sapiens	42-45
33321687-0	2020	Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y Cells.	Oxygen	84-90	APC regulator of WNT signaling pathway	Homo sapiens	27-46
33309782-4	2021	We exemplify this approach by editing VEGFR2 in retinal vascular endothelial cells in a mouse model of oxygen-induced retinopathy, and expect that this simplified protocol can be expanded to other researches on editing endothelial genome in vivo.	Oxygen	103-109	kinase insert domain protein receptor	Mus musculus	38-44
33877179-7	2021	These data explain why landmark, structurally characterized, mu2-eta1,eta2-peroxide and eta1-superoxide Co(salen)-O2 adducts were predominantly isolated from solvents with high C-H pKa values (DMSO, DMF, DMA).	Oxygen	114-116	adaptor related protein complex 1 subunit mu 2	Homo sapiens	61-64
33875994-5	2021	By means of photoconductances, it is shown that the Cu dopants could catalyze the electron transfer from TiO2 to O2 by reducing the apparent activation energy (Eapp) by about 2 times.	Oxygen	107-109	E2F associated phosphoprotein	Homo sapiens	160-164
13773594-0	1960	[On the differentiation of cyanosis caused by shunt and diffusion with the aid of various partial oxygen pressures in inspired air].	Oxygen	98-104	activation induced cytidine deaminase	Homo sapiens	75-78
33924614-3	2021	Expression of osterix (OSX) and vascular endothelial growth factor A (VEGFA) was significantly enhanced in the 3D scaffold in all oxygen environments.	Oxygen	130-136	Sp7 transcription factor	Homo sapiens	14-21
33924614-3	2021	Expression of osterix (OSX) and vascular endothelial growth factor A (VEGFA) was significantly enhanced in the 3D scaffold in all oxygen environments.	Oxygen	130-136	Sp7 transcription factor	Homo sapiens	23-26
33293563-3	2020	For all possible reaction intermediates, the calculated changes in Gibbs free energy showed that the oxygen evolution reaction will occur at, and above, the potential of 2.06 V (against the NHE) as all elementary steps are exergonic.	Oxygen	101-107	solute carrier family 9 member C1	Homo sapiens	190-193
31216141-6	1959	In calcite the carbon-oxygen symmetric stretching, mode v 1, becomes active at elevated pressures while the doubly degenerate v 3, stretching, and v 4, bending, frequencies split.	Oxygen	22-28	immunoglobulin kappa variable 1-5	Homo sapiens	56-59
32050841-4	2020	In this study, we aimed to explore the biological role of miR-211 in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and transient cerebral ischemia/reperfusion (I/R) injury in vitro and in vivo.	Oxygen	107-121	microRNA 211	Rattus norvegicus	58-65
33845913-7	2021	AOC3 inhibition reduces leukocyte recruitment and is predicted to decrease the production of reactive oxygen species, thereby correcting the underlying hypoxia, ischemia, and edema seen in DR, as well as improving vascular function.	Oxygen	102-108	amine oxidase copper containing 3	Homo sapiens	0-4
33482573-2	2021	Spectral shifts in the characteristic nuC=O region of acetone, as well as in the fingerprint regions, are unambiguously assigned to the formation of halogen bond involving one of the halogen atoms on CBr4/CCl4 as donor, and the carbonyl oxygen of acetone as acceptor.	Oxygen	237-243	nucleobindin 1	Homo sapiens	38-41
13652477-0	1959	[Effect of the intracellular phosphate (P31 &amp; P32) concentration on oxygen consumption in a strain of Proteus &amp; its fixed L form].	Oxygen	72-78	inhibitor of growth family member 2	Homo sapiens	50-53
33149789-0	2020	MicroRNA-210 improves perfusion recovery following hindlimb ischemia via suppressing reactive oxygen species.	Oxygen	94-100	microRNA 210	Homo sapiens	0-12
13633608-0	1958	[Effects of cytochrome c administration on oxygen consumption &amp; carbon dioxide elimination in rabbits poisoned by carbon monoxide].	Oxygen	43-49	cytochrome c	Oryctolagus cuniculus	12-24
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin dependent kinase 4	Homo sapiens	212-242
32557804-12	2021	Consistently, either LXRalpha activation or the let-7a/miR-34a transfection lowered mitochondrial oxygen consumption rate and mitochondrial transmembrane potential and increased fat levels.	Oxygen	98-104	microRNA let7a-1	Mus musculus	48-54
33581266-7	2021	The production of reactive oxygen species, ER stress, and autophagic stress induced by MPTP were also significantly block ed in PD mice overexpressing PHB.	Oxygen	27-33	prohibitin	Mus musculus	151-154
33461096-0	2021	Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage.	Oxygen	9-15	high mobility group box 1	Homo sapiens	61-66
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin D1	Homo sapiens	247-256
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin dependent kinase 4	Homo sapiens	369-373
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin D1	Homo sapiens	378-387
32721518-2	2020	Here we have shown that, under the conditions of a gradual decrease in dissolved oxygen (dO2), characteristic of batch culture, the global regulatory system ArcB/ArcA can play an important role in the coordinated control of extracellular superoxide and GSH fluxes and their interaction with intracellular antioxidant systems.	Oxygen	81-87	arginine deiminase	Escherichia coli	162-166
33548649-6	2021	Moreover, we proposed a photocatalytic degradation mechanism based on the radical scavenging results, which disclosed that the  O2- and  OH species perform essential tasks for the photodegradation of antibiotics by Ag/Ag2S/Ag3PO4 nanocomposites.	Oxygen	128-131	angiotensin II receptor type 1	Homo sapiens	218-222
33265962-0	2020	Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation.	Oxygen	102-108	LRR binding FLII interacting protein 1	Rattus norvegicus	31-38
33261036-1	2020	BACKGROUND: The objective of this study was to establish the reliability of the Humon Hex near-infrared reflectance spectroscopy (NIRS) in determining muscle oxygen saturation (SmO2) and hemoglobin concentration (Hgb) at rest and during isometric and dynamic strength exercises using a functional electromechanical dynamometer (FEMD).	Oxygen	158-164	hematopoietically expressed homeobox	Homo sapiens	86-89
33244644-4	2020	It was found that there are no indication on formation on hydrogen bonding between the two catecholic OHs where the one formed between the amino group and the hydroxyl oxygen atom of adrenaline monomer was broken in AS1 to form two new interactions namely SH...N and O1H1...S, while it retained in other complexes.	Oxygen	168-174	prostaglandin D2 receptor	Homo sapiens	216-219
33228532-9	2020	Complement (C3), CXCL2, and HMOX1 were defined as links between inflammatory pathways and those involved in the generation of reactive oxygen species.	Oxygen	135-141	heme oxygenase 1	Bos taurus	28-33
32040846-2	2020	Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se).	Oxygen	123-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
32040846-2	2020	Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se).	Oxygen	123-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
32599385-6	2020	Characterization using various techniques such as XRD, TEM, BET, XPS, H2-TPR and CO2-TPD showed that Co3+ and surface adsorbed oxygen (Osur) enriched surface, excellent redox properties and effective diffusion of the reaction product reasonably explain the enhancement in catalytic activity over the E--NiCo2O4.	Oxygen	127-133	delta/notch like EGF repeat containing	Homo sapiens	60-63
32604560-0	2020	Improvement of Oxygen Mobility with the Formation of Defects in the Crystal Structure of Red Mud as an Oxygen Carrier for Chemical Looping Combustion.	Oxygen	15-21	adaptor related protein complex 5 subunit mu 1	Homo sapiens	93-96
32604560-0	2020	Improvement of Oxygen Mobility with the Formation of Defects in the Crystal Structure of Red Mud as an Oxygen Carrier for Chemical Looping Combustion.	Oxygen	103-109	adaptor related protein complex 5 subunit mu 1	Homo sapiens	93-96
32604560-1	2020	Fe2O3 is the major component of red mud, which is a by-produced after eluting aluminum from bauxite in the Bayer process, and can be used as an oxygen carrier.	Oxygen	144-150	adaptor related protein complex 5 subunit mu 1	Homo sapiens	36-39
32604560-2	2020	On the other hand, red mud is unsuitable for using oxygen in the crystal lattice because of its low surface area.	Oxygen	51-57	adaptor related protein complex 5 subunit mu 1	Homo sapiens	23-26
32604560-3	2020	In this study the red-mud sample was sulfidated at high temperatures to improve the lattice oxygen mobility by forming lattice defects in the iron oxide crystals.	Oxygen	92-98	adaptor related protein complex 5 subunit mu 1	Homo sapiens	22-25
32604560-8	2020	In addition, the formation of crystal defects increased the oxygen transfer capacity of red mud from 1.75% to 2.25% at 15 vol.% hydrogen.	Oxygen	60-66	adaptor related protein complex 5 subunit mu 1	Homo sapiens	92-95
33363343-3	2020	This research focused on examining the effect of low oxygen tension on the ability of bone marrow-derived mesenchymal stem cells (BM-MSCs) to express OCT4 and SOX2 in vitro.	Oxygen	53-59	POU domain, class 5, transcription factor 1	Oryctolagus cuniculus	150-154
33363343-7	2020	The expression of OCT4 and SOX2 was measured by immunofluorescence staining after 48 h of incubation in chambers with normal or low oxygen tension with controlled internal atmosphere consisting of 95% N2, 5% CO2, and 1% O2 (T1) and 3% O2 (T2).	Oxygen	220-222	POU domain, class 5, transcription factor 1	Oryctolagus cuniculus	18-22
33363343-11	2020	Oxygen tension culture conditions of 1% and 3% O2 led to OCT4 and SOX2 expression on culture days 2 and 4 (p<0.05), respectively, as compared to the hyperoxia condition (21% O2).	Oxygen	0-6	POU domain, class 5, transcription factor 1	Oryctolagus cuniculus	57-61
33363343-11	2020	Oxygen tension culture conditions of 1% and 3% O2 led to OCT4 and SOX2 expression on culture days 2 and 4 (p<0.05), respectively, as compared to the hyperoxia condition (21% O2).	Oxygen	47-49	POU domain, class 5, transcription factor 1	Oryctolagus cuniculus	57-61
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Oxygen	221-227	frataxin	Homo sapiens	0-4
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Oxygen	221-227	frataxin	Homo sapiens	36-44
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Oxygen	221-227	frataxin	Homo sapiens	46-49
32915537-6	2020	Both in vitro and in vivo results demonstrated that the obtained O2@PFOB@PGL NPs could act as a prominent oxygen reservoir and effectively replenish oxygen into the hypoxic tumors with no need for external stimulation, conducing to augmented singlet oxygen generation, hypoxia relief and subsequent down-regulation of COX-2 expression.	Oxygen	65-67	cytochrome c oxidase II, mitochondrial	Mus musculus	318-323
32915537-6	2020	Both in vitro and in vivo results demonstrated that the obtained O2@PFOB@PGL NPs could act as a prominent oxygen reservoir and effectively replenish oxygen into the hypoxic tumors with no need for external stimulation, conducing to augmented singlet oxygen generation, hypoxia relief and subsequent down-regulation of COX-2 expression.	Oxygen	106-112	cytochrome c oxidase II, mitochondrial	Mus musculus	318-323
32915537-6	2020	Both in vitro and in vivo results demonstrated that the obtained O2@PFOB@PGL NPs could act as a prominent oxygen reservoir and effectively replenish oxygen into the hypoxic tumors with no need for external stimulation, conducing to augmented singlet oxygen generation, hypoxia relief and subsequent down-regulation of COX-2 expression.	Oxygen	149-155	cytochrome c oxidase II, mitochondrial	Mus musculus	318-323
33110217-6	2020	sFLG raises reactive oxygen species and calcium from 24 h to one week after the treatment and this involves the activation of NADPH oxidase 1.	Oxygen	21-27	NADPH oxidase 1	Homo sapiens	126-141
33104520-9	2020	As ACE2 expression is regulated by various conditions, including oxygen concentration, inflammation and smoking, caution is warranted to avoid triggering potential ACE2 expression in fetal and placental tissue.	Oxygen	65-71	angiotensin converting enzyme 2	Homo sapiens	3-7
33093455-0	2020	Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model.	Oxygen	154-160	interleukin 18	Mus musculus	123-128
32574913-5	2020	The as-prepared composite of carbon fibers and FeNi alloy nanoparticles exhibited a small overpotential of 317 mV at 10 mA cm-2 and low Tafel slope of 49 mV dec-1 for oxygen evolution reaction, as well as good stability.	Oxygen	167-173	deleted in esophageal cancer 1	Homo sapiens	157-162
32791151-10	2020	Hyperbaric oxygen promoted the proliferation, migration and ROS production, as well as the expression of SDF-1 and VEGFA in HSF.	Oxygen	11-17	chemokine (C-X-C motif) ligand 12	Mus musculus	105-110
33066332-1	2020	Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway.	Oxygen	190-196	solute carrier family 3 member 1	Homo sapiens	104-128
32902246-6	2020	Analysis of characterization by XPS, TGA, FTIR shows that dGO oxygen functionalization is predominantly related to defects, such as flake edges and edge atoms of holes, whereas standard GO exhibits oxygen functional groups mostly on the planar surface.	Oxygen	62-68	diego	Drosophila melanogaster	59-61
33028901-1	2020	Alcohol dehydrogenase (ADH) and pyruvate decarboxylase (PDC) are key to the establishment of the fermentative metabolism in plants during oxygen shortage.	Oxygen	138-144	alcohol dehydrogenase 1	Arabidopsis thaliana	0-21
33022006-11	2020	Multivariate analysis revealed prolonged use of oxygen therapy (AHR = 4.972, 95% CI [1.041-23.736] and frequent hospital admissions (AHR = 11.482 [1.308-100.793]) to be independent risk factors for early readmissions.	Oxygen	48-54	aryl hydrocarbon receptor	Homo sapiens	64-67
31880198-8	2020	In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type.	Oxygen	657-663	autophagy related 4B cysteine peptidase	Homo sapiens	129-134
31880198-8	2020	In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type.	Oxygen	657-663	autophagy related 4B cysteine peptidase	Homo sapiens	209-214
31884871-11	2020	Thus, our studies discover the TGFB-INHB/activin-mediated inhibition of TORC2 as a novel mechanism for age-dependent decreases in autophagic activity and cardiac health.Abbreviations: AI: arrhythmia index; BafA1: bafilomycin A1; BMP: bone morphogenetic protein; CQ: chloroquine; CVD: cardiovascular diseases; DI: diastolic interval; ER: endoplasmic reticulum; HP: heart period; HR: heart rate; MTOR: mechanistic target of rapamycin kinase; NGS: normal goat serum; PBST: PBS with 0.1% Triton X-100; PDPK1: 3-phosphoinositide dependent protein kinase 1; RICTOR: RPTOR independent companion of MTOR complex 2; ROI: region of interest; ROUT: robust regression and outlier removal; ROS: reactive oxygen species; R-SMAD: receptor-activated SMAD; SI: systolic interval; SOHA: semi-automatic optical heartbeat analysis; TGFB: transformation growth factor beta; TSC1: TSC complex subunit 1.	Oxygen	691-697	glass bottom boat	Drosophila melanogaster	31-35
31884871-11	2020	Thus, our studies discover the TGFB-INHB/activin-mediated inhibition of TORC2 as a novel mechanism for age-dependent decreases in autophagic activity and cardiac health.Abbreviations: AI: arrhythmia index; BafA1: bafilomycin A1; BMP: bone morphogenetic protein; CQ: chloroquine; CVD: cardiovascular diseases; DI: diastolic interval; ER: endoplasmic reticulum; HP: heart period; HR: heart rate; MTOR: mechanistic target of rapamycin kinase; NGS: normal goat serum; PBST: PBS with 0.1% Triton X-100; PDPK1: 3-phosphoinositide dependent protein kinase 1; RICTOR: RPTOR independent companion of MTOR complex 2; ROI: region of interest; ROUT: robust regression and outlier removal; ROS: reactive oxygen species; R-SMAD: receptor-activated SMAD; SI: systolic interval; SOHA: semi-automatic optical heartbeat analysis; TGFB: transformation growth factor beta; TSC1: TSC complex subunit 1.	Oxygen	691-697	Activin-beta	Drosophila melanogaster	41-48
32388677-4	2020	Mechanistically, in the GC cells under the 5-FU treatment, reactive oxygen species is accumulated and then induces the activation of HIF1alpha signaling to drive the expression of high-mobility group box 1, which leads to more macrophage"s infiltration into GC tumor.	Oxygen	68-74	high mobility group box 1	Homo sapiens	180-205
32903101-12	2020	Our data identify a specific reactive oxygen species ASK1 p38-MAPK pathway in the heart and establish that ASK1 inhibitors protect the heart from hypertension-induced cardiac remodeling.	Oxygen	38-44	mitogen activated protein kinase 14	Rattus norvegicus	58-61
32017068-8	2020	Mechanistically, Pak2 inhibition induced reactive oxygen species overproduction, mitochondria-JNK pathway activation, and AMPK-YAP axis suppression.	Oxygen	50-56	p21 (RAC1) activated kinase 2	Homo sapiens	17-21
32609042-12	2020	Sestrin2 was positively correlated with oxygen reduction index and negatively correlated with mean oxygen saturation and lowest oxygen saturation.	Oxygen	40-46	sestrin 2	Homo sapiens	0-8
32609042-12	2020	Sestrin2 was positively correlated with oxygen reduction index and negatively correlated with mean oxygen saturation and lowest oxygen saturation.	Oxygen	99-105	sestrin 2	Homo sapiens	0-8
32943729-0	2020	Androgen receptor modulates metastatic routes of VHL wild-type clear cell renal cell carcinoma in an oxygen-dependent manner.	Oxygen	101-107	von Hippel-Lindau tumor suppressor	Homo sapiens	49-52
32943729-3	2020	Here we found that AR interacted with VHL to modulate the metastasis of VHL-wt ccRCC via an oxygen-dependent manner.	Oxygen	92-98	von Hippel-Lindau tumor suppressor	Homo sapiens	38-41
32943729-3	2020	Here we found that AR interacted with VHL to modulate the metastasis of VHL-wt ccRCC via an oxygen-dependent manner.	Oxygen	92-98	von Hippel-Lindau tumor suppressor	Homo sapiens	72-75
32943729-6	2020	These distinct AR functions under different oxygen conditions may involve the VHL-impacted ubiquitination and nuclear localization of AR.	Oxygen	44-50	von Hippel-Lindau tumor suppressor	Homo sapiens	78-81
32813332-5	2020	In brite adipocytes, mirabegron increased cyclic AMP levels and UCP1 mRNA content resulting in increased UCP1-mediated oxygen consumption, glucose uptake, and cellular glycolysis.	Oxygen	119-125	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	105-109
33377014-4	2020	Meaningful oxygen consumption analyses require (1) the activation of UCP1, (2) control over intracellular free-fatty-acid levels, and (3) inhibition of ATP-consuming futile cycles.	Oxygen	11-17	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	69-73
32953572-0	2020	Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy.	Oxygen	95-101	acetylcholinesterase	Mus musculus	0-20
32953572-1	2020	AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR).	Oxygen	169-175	acetylcholinesterase	Mus musculus	42-62
32953572-1	2020	AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR).	Oxygen	169-175	acetylcholinesterase	Mus musculus	64-68
33859647-0	2021	High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis.	Oxygen	5-11	forkhead box N1	Homo sapiens	58-63
33859647-7	2021	High oxygen submersion (HOS)-FTOCs restored the expression of FOXN1 and its target genes, as well as maintained high levels of MHCII expression in TECs.	Oxygen	5-11	forkhead box N1	Homo sapiens	62-67
33859647-10	2021	Given that oxidative stress has been reported to accelerate the onset of age-associated thymic involution, we postulate that regulation of FOXN1 by oxygen and antioxidants may underpin this biological process.	Oxygen	148-154	forkhead box N1	Homo sapiens	139-144
33841100-10	2021	Increased levels of ATP, restoration of mitochondrial membrane potential, and decreased production of mitochondrial reactive oxygen species after Abeta treatment in the presence of 4mu8c showed that inhibiting the IRE1alpha-XBP1 axis effectively mitigated Abeta-induced mitochondrial dysfunction in SH-SY5Y cells.	Oxygen	125-131	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	214-223
33151437-7	2021	In phi1, during MAP decrease, BRS was lower than in PRE-ss at rest (6.6 [5.3-11.4] in air and 7.7 [4.9-14.3] in O2, p < 0.05).	Oxygen	112-114	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	3-7
33151437-8	2021	At exercise, BRS in phi1 was 6.4 [3.9-13.1] in air and 6.7 [4.1-9.5] in O2.	Oxygen	72-74	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	20-24
33423297-4	2021	We found that mdx-Mss51 KO mice had increased myofiber oxygen consumption rates and an amelioration of muscle histopathology compared to mdx counterparts.	Oxygen	55-61	MSS51 mitochondrial translational activator	Mus musculus	18-23
33615821-10	2021	Exercise CO and mPAP/CO slope are the best predictors of peak oxygen consumption and ventilation to carbon dioxide production slope classifications representing the main targets of interventions to impact functional class and, likely, event rate.	Oxygen	62-68	phospholipid phosphatase 1	Mus musculus	16-20
32632982-7	2021	Consequently, CPT1C gain-of-function significantly reversed mitochondrial dysfunction, as evaluated by increased adenosine triphosphate synthesis and mitochondrial transmembrane potential, decreased radical oxygen species, upregulated respiratory capacity and mRNA expression of genes related to mitochondrial function.	Oxygen	207-213	carnitine palmitoyltransferase 1C	Homo sapiens	14-19
33513822-11	2021	A possible mechanism of the effects of the two drugs together with polyP on mucin expression is proposed based on the scavenging of free oxygen species and the generation of ADP/ATP from the polyP, which is needed for the organization of the protective mucin-based mucus layer.	Oxygen	137-143	LOC100508689	Homo sapiens	76-81
33503814-5	2021	Other studies suggest that stimulation of NOD1 or NOD2 by their bacterial ligands can result in inflammation, altered insulin responses, increased reactive oxygen signaling, and mitochondrial dysfunction.	Oxygen	156-162	nucleotide-binding oligomerization domain containing 2	Mus musculus	50-54
33503868-4	2021	PCCA iPSC-derived cardiomyocytes exhibited reduced oxygen consumption, an accumulation of residual bodies and lipid droplets, and increased ribosomal biogenesis.	Oxygen	51-57	propionyl-CoA carboxylase subunit alpha	Homo sapiens	0-4
33498264-8	2021	Interestingly, select members of the CX9C protein family, including MNRR1 and CHCHD10, show a novel feature in that they not only localize to the mitochondria but also to the nucleus, where they mediate oxygen- and stress-induced transcriptional regulation, opening a new view of mitochondrial-nuclear crosstalk and its involvement in human disease.	Oxygen	203-209	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	68-73
33413076-14	2021	The expression levels of circRIMS2 and BDNF in the oxygen and glucose deprivation-treated (OGD-treated) cells were decreased, the miR-186 expression and cell apoptosis were increased, while the effect was weakened after transfection with the lentiviral vector pLO-ciR-RIMS2.	Oxygen	51-57	regulating synaptic membrane exocytosis 2	Mus musculus	29-34
33400016-6	2021	Finally, our animal study also showed that intravitreal injection of small interfering RNA of YAP or PFKFB3 dramatically suppressed the neovascular growth in mouse models of choroidal neovascularization and oxygen-induced retinopathy.	Oxygen	207-213	yes-associated protein 1	Mus musculus	94-97
33401635-6	2021	Oxygen content during process is also crucial because the hole-conductive p-type SnO channel is oxidized into oxygen-rich n-type SnO2 to demote the device performance.	Oxygen	110-116	strawberry notch homolog 1	Homo sapiens	81-84
33112654-6	2021	Organ culture for 72h under 1% O2 decreased total MLCK abundance in FN and FH carotid arteries, but decreased the contractile MLCK abundance only in FH carotid arteries.	Oxygen	31-33	myosin light chain kinase, smooth muscle	Ovis aries	50-54
33112654-6	2021	Organ culture for 72h under 1% O2 decreased total MLCK abundance in FN and FH carotid arteries, but decreased the contractile MLCK abundance only in FH carotid arteries.	Oxygen	31-33	myosin light chain kinase, smooth muscle	Ovis aries	126-130
33218686-3	2021	In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration.	Oxygen	27-29	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	31-35
32789757-6	2021	Both, XO and XDH, catalyse the conversion of hypoxanthine via xanthine to uric acid, the former by using oxygen forming superoxide and hydrogen peroxide and the latter NAD+.	Oxygen	105-111	xanthine dehydrogenase	Homo sapiens	13-16
33631975-0	2021	EXPRESSION OF CONCERN: "MicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation induced apoptosis".	Oxygen	74-80	microRNA 132	Homo sapiens	23-36
32043277-1	2021	VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2 ) regulated target of the PCO branch of the PRT6 N-degron pathway of ubiquitin-mediated proteolysis.	Oxygen	105-111	proteolysis 6	Arabidopsis thaliana	160-164
33264701-8	2021	We show that CPD-evoked mitochondrial reactive oxygen species production, followed by the activation of several energy sensor enzymes, including sirtuins, AMPK, mTORC1, mTORC2, p53, and ATM, is responsible for the compensatory metabolic adaptations in keratinocytes surviving UVB irradiation.	Oxygen	47-53	CREB regulated transcription coactivator 2	Mus musculus	169-175
33245314-1	2020	Metallocorroles and metalloporphyrins (M-N-C) are some of the best alternative molecular catalysts for the replacement of the expensive platinum-group metals (PGM) in oxygen reduction reaction (ORR) catalysis in polymer electrolyte membrane (PEM) fuel cells.	Oxygen	167-173	mucin 1, cell surface associated	Homo sapiens	242-245
33328510-4	2020	In this study, we demonstrate that the expressions of HOTAIRM1 and its target HOXA1 are substantially upregulated to promote the expressions of immunosuppressive molecules, including arginase 1, inducible nitric oxide synthase, signal transducer and activator of transcription 3, and reactive oxygen species, in CD33+ myeloid cells derived from hepatitis C virus (HCV)-infected patients.	Oxygen	293-299	homeobox A1	Homo sapiens	78-83
33038397-4	2020	The results showed that oxygen plasma irradiation improved the hydrophilicity of the SiOx surface and the adhesive strength between SiOx-CS of PLA/SiOx/CS films in a time-dependent manner.	Oxygen	24-30	citrate synthase	Homo sapiens	137-139
33237716-0	2020	On the Origin of the Effect of pH in Oxygen Reduction Reaction for Nondoped and Edge-Type Quaternary N-Doped Metal-Free Carbon-Based Catalysts.	Oxygen	37-43	phenylalanine hydroxylase	Homo sapiens	31-33
32815956-2	2020	Using the first-principles calculation, we studied the effects of multi-hydrogen-tin/oxygen vacancy complex impurities on the electronic properties of the p-type monolayer SnO.	Oxygen	85-91	strawberry notch homolog 1	Homo sapiens	172-175
32911610-7	2020	In MTC-derived TT cells, COX4 silencing inhibited p70S6K/pS6 and p-ERK signaling, and was associated with decreased oxygen consumption and ATP production.	Oxygen	116-122	cytochrome c oxidase subunit 4I1	Homo sapiens	25-29
32963690-7	2020	At these sites with the higher acidity, the chance of protonation of the superoxide radical (O2  ), generated by the respiratory chain, is much higher with the formation of the highly reactive hydrophobic perhydroxyl radical (HO2  ).	Oxygen	93-95	heme oxygenase 2	Homo sapiens	226-229
33789133-3	2021	COMT activity influences the functional connectivity of the PFC at rest, as well as its activity during task performance, determined using blood oxygen level-dependent (BOLD) fMRI.	Oxygen	145-151	catechol-O-methyltransferase	Homo sapiens	0-4
32819574-5	2020	Finally, we turned our attention to inflammatory mediators derived from the cleavage of citrate catalyzed by ACLY: prostaglandin E2, nitric oxide and reactive oxygen species.	Oxygen	159-165	ATP citrate lyase	Mus musculus	109-113
33042622-9	2020	GPI was found to be downstream effector of HP while knockdown of GPI led to decreased glycolytic activity and restored oxygen consumption.	Oxygen	119-125	glucose-6-phosphate isomerase	Homo sapiens	65-68
32649928-5	2020	In vitro, we found that oxygen deficiency leads to H19 upregulation in several cardiac cell types.	Oxygen	24-30	H19, imprinted maternally expressed transcript	Mus musculus	51-54
32403173-8	2020	The between-leg difference in O2 extraction correlated with the between-leg ratio of citrate synthase and COX-IV (r = .72-.73; P = .03), but not with the difference in the capillary-to-fiber ratio (P = .965).	Oxygen	30-32	citrate synthase	Homo sapiens	85-101
32403173-8	2020	The between-leg difference in O2 extraction correlated with the between-leg ratio of citrate synthase and COX-IV (r = .72-.73; P = .03), but not with the difference in the capillary-to-fiber ratio (P = .965).	Oxygen	30-32	cytochrome c oxidase subunit 4I1	Homo sapiens	106-112
32631903-0	2020	Janus Kinase mutations in mice lacking PU.1 and Spi-B drive B cell leukemia through reactive oxygen species-induced DNA damage.	Oxygen	93-99	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	39-43
32008376-1	2020	SIGNIFICANCE: The primary function of NADPH oxidases (NOX1-5 and dual oxidases DUOX1/2) is to produce reactive oxygen species (ROS).	Oxygen	111-117	NADPH oxidase 1	Homo sapiens	54-60
32008376-1	2020	SIGNIFICANCE: The primary function of NADPH oxidases (NOX1-5 and dual oxidases DUOX1/2) is to produce reactive oxygen species (ROS).	Oxygen	111-117	dual oxidase 1	Homo sapiens	79-86
32831861-6	2020	We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway.	Oxygen	148-154	mitogen activated protein kinase 3	Rattus norvegicus	163-169
32764539-5	2020	Compared to the traditional support stabilized catalysts such as Pd@CeO2, Pd1@HEFO affords the improved reducibility of lattice oxygen and the existence of stable Pd-O-M species, thus exhibiting not only higher low-temperature CO oxidation activity but also outstanding resistance to thermal and hydrothermal degradation.	Oxygen	128-134	programmed cell death 1	Homo sapiens	74-82
32356371-1	2020	The dinuclear copper enzyme tyrosinase activates O2  to form a (mu-eta2:eta2-peroxido)dicopper(II) species, which hydroxylates phenols to catechols.	Oxygen	49-51	DNA polymerase iota	Homo sapiens	67-71
32780864-2	2020	Our previous work showed that CNTF-induced STAT3 signaling is a potent inhibitor of pathologic preretinal neovascular tuft formation in the mouse model of oxygen-induced retinopathy.	Oxygen	155-161	ciliary neurotrophic factor	Mus musculus	30-34
32535108-5	2020	On the other hand, in case of microbial defense, AHR-regulated neutrophils and Th17 cells are involved in generation of bactericidal reactive oxygen species and pro-inflammatory stimuli.	Oxygen	142-148	aryl hydrocarbon receptor	Homo sapiens	49-52
32590225-1	2020	TNF Receptor Associated Protein 1 (TRAP1) is a mitochondrial paralog of Hsp90 related to the promotion of tumorigenesis in various cancers via maintaining mitochondrial integrity, reducing the production of reactive oxygen species, and reprogramming cellular metabolism.	Oxygen	216-222	TNF receptor-associated protein 1	Mus musculus	0-33
32590225-1	2020	TNF Receptor Associated Protein 1 (TRAP1) is a mitochondrial paralog of Hsp90 related to the promotion of tumorigenesis in various cancers via maintaining mitochondrial integrity, reducing the production of reactive oxygen species, and reprogramming cellular metabolism.	Oxygen	216-222	TNF receptor-associated protein 1	Mus musculus	35-40
31800011-16	2020	However, we demonstrated that Nox4, one of the main sources for reactive oxygen species is essential for exercise-mediated adaptations in the vasculature and the skeletal muscle.	Oxygen	73-79	NADPH oxidase 4	Mus musculus	30-34
32432414-2	2020	Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species.	Oxygen	149-155	xanthine dehydrogenase	Homo sapiens	0-23
32432414-2	2020	Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species.	Oxygen	149-155	xanthine dehydrogenase	Homo sapiens	25-28
32618099-10	2020	LIPH silencing promoted apoptosis, arrested cell cycle in the G2/M phase, mitigated the oxidation-related oxygen consumption rate in the mitochondria, and reduced metabolism.	Oxygen	106-112	lipase H	Homo sapiens	0-4
32430489-8	2020	Furthermore, oxygen consumption rate was increased following MEKi + CDK4/6i treatment.	Oxygen	13-19	cyclin dependent kinase 4	Homo sapiens	68-75
32802036-3	2020	In the present study, we demonstrated that expressions of Shh, Ptch, and Gli-1 were significantly downregulated at 24 h following oxygen-glucose deprivation (OGD) injury in neurons in vitro, effects which were associated with increasing numbers of apoptotic cells and reactive oxygen species generation.	Oxygen	130-136	patched 1	Rattus norvegicus	63-67
32802036-3	2020	In the present study, we demonstrated that expressions of Shh, Ptch, and Gli-1 were significantly downregulated at 24 h following oxygen-glucose deprivation (OGD) injury in neurons in vitro, effects which were associated with increasing numbers of apoptotic cells and reactive oxygen species generation.	Oxygen	130-136	GLI family zinc finger 1	Rattus norvegicus	73-78
32740581-8	2020	RESULTS: Hyperbaric oxygen therapy with 3 atm increased viability, proliferation, and CD34 expression and reduced the CD31/CD34/CD45 adipose-derived stem cell subset and endothelial progenitor cell population.	Oxygen	20-26	platelet and endothelial cell adhesion molecule 1	Homo sapiens	118-122
32740581-9	2020	TGF-beta levels were significantly decreased after two hyperbaric oxygen therapy sessions in the 2-atm group and decreased after three hyperbaric oxygen therapy sessions in the 3-atm group.	Oxygen	66-72	transforming growth factor alpha	Homo sapiens	0-8
32740581-9	2020	TGF-beta levels were significantly decreased after two hyperbaric oxygen therapy sessions in the 2-atm group and decreased after three hyperbaric oxygen therapy sessions in the 3-atm group.	Oxygen	146-152	transforming growth factor alpha	Homo sapiens	0-8
32740581-12	2020	CONCLUSION: Hyperbaric oxygen therapy with 3 atm increases viability and proliferation of adipose-derived stem cells, alters marker expression and subpopulations, decreases TGF-beta secretion, and skews adipose-derived stem cells toward adipogenic differentiation.	Oxygen	23-29	transforming growth factor alpha	Homo sapiens	173-181
32505355-5	2020	Consistently, TBK1 overexpression ameliorated mitochondrial oxygen consumption rate (OCR) in neonatal rat cardiomyocytes (NRCMs) in response to hypoxia/reoxygenation (H/R) injury.	Oxygen	60-66	TANK-binding kinase 1	Rattus norvegicus	14-18
32706394-5	2020	Among the ROS products, hydrogen peroxide (H2 O2 ) rather than superoxide (O2 - ) played a critical role in SHR mediated periclinal division.	Oxygen	75-79	GRAS family transcription factor	Arabidopsis thaliana	108-111
33243973-5	2020	Using rescue experiments with a brain extracellular extract, and direct measurements, we demonstrate that cytosolic serine starvation controls cell movement by increasing reactive oxygen species formation and decreasing ATP levels, thereby promoting activation of the AMP sensor kinase (AMPK) by phosphorylation.	Oxygen	180-186	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	287-291
32692342-4	2020	Hypoxic cells incubated with NE CuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.	Oxygen	93-99	cullin 1	Homo sapiens	32-36
33298866-11	2020	Deletion of IRE1alpha decreased maximal and ATP-linked oxygen consumption, as well as mitochondrial membrane potential.	Oxygen	55-61	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	12-21
33201372-2	2021	Previously we have shown that Nox4 is highly expressed in retinal blood vessels and is upregulated in oxygen-induced retinopathy (OIR).	Oxygen	102-108	NADPH oxidase 4	Mus musculus	30-34
33121245-4	2020	The remaining two MPQ anions are unidentate toward the lanthanide and form mu2-bridges via the deprotonated quinolinate oxygens to a bound NaI cation which is also coordinated to the remaining nitrogen donor atoms.	Oxygen	120-127	adaptor related protein complex 1 subunit mu 2	Homo sapiens	75-78
33184433-2	2020	In various mammalian cells, Tet methylcytosine dioxygenase 2 (Tet2) catalyzes oxygen transfer to a methyl group of 5-methylcytosine (5mC), yielding 5-hydroxymethylcytocine (5hmC).	Oxygen	49-55	tet methylcytosine dioxygenase 2	Homo sapiens	62-66
32929889-5	2020	In alkaline electrolyte, the Co/MnO@N-C presents the outstanding oxygen evolution reaction (OER) performance comparable to the commercial RuO2 catalyst and the exceedingly good oxygen reduction reaction (ORR) activity with positive half-wave potential of 0.90 V vs. RHE outperforming commercial Pt/C (0.84 V vs. RHE) and the recently reported analogous electrocatalysts.	Oxygen	65-71	factor interacting with PAPOLA and CPSF1	Homo sapiens	266-269
32929889-5	2020	In alkaline electrolyte, the Co/MnO@N-C presents the outstanding oxygen evolution reaction (OER) performance comparable to the commercial RuO2 catalyst and the exceedingly good oxygen reduction reaction (ORR) activity with positive half-wave potential of 0.90 V vs. RHE outperforming commercial Pt/C (0.84 V vs. RHE) and the recently reported analogous electrocatalysts.	Oxygen	65-71	factor interacting with PAPOLA and CPSF1	Homo sapiens	312-315
33017192-0	2020	Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice.	Oxygen	73-79	small proline-rich protein 2F	Mus musculus	0-6
33017192-7	2020	Consistently, bilateral ischemia-reperfusion injury resulted in higher serum blood urea nitrogen levels and higher tissue reactive oxygen species in Sprr2f-KO compared with Sprr2f-WT female mice.	Oxygen	131-137	small proline-rich protein 2F	Mus musculus	149-155
33017192-8	2020	Moreover, cultured renal epithelial cells from Sprr2f-KO female mice showed lower viability after oxidative damage induced by menadione compared with Sprr2f-WT cells that could be rescued by supplementation with reduced glutathione, suggesting that Sprr2f induction after renal damage acts as a defense against reactive oxygen species.	Oxygen	320-326	small proline-rich protein 2F	Mus musculus	47-53
33086191-11	2020	Knockdown of PDK2 resulted in lower lactate production, stronger oxygen consumption, weaker proliferation activity, and less cytoplasmic Akt in the TAO pOFs but showed no significant effects in the control pOFs.	Oxygen	65-71	pyruvate dehydrogenase kinase 2	Homo sapiens	13-17
32901885-0	2020	Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin-induced type 1 diabetes mouse model.	Oxygen	88-94	ghrelin	Mus musculus	0-7
33142830-3	2020	The key molecules of the hypoxia/oxygen-sensing signaling include the transcriptional regulator hypoxia-inducible factor (HIF) which widely controls oxygen responsive genes, the central members of the 2-oxoglutarate (2-OG)-dependent dioxygenases, such as prolyl hydroxylase (PHD or EglN), and an E3 ubiquitin ligase component for HIF degeneration called von Hippel-Lindau (encoding protein pVHL).	Oxygen	33-39	von Hippel-Lindau tumor suppressor	Homo sapiens	390-394
33142830-3	2020	The key molecules of the hypoxia/oxygen-sensing signaling include the transcriptional regulator hypoxia-inducible factor (HIF) which widely controls oxygen responsive genes, the central members of the 2-oxoglutarate (2-OG)-dependent dioxygenases, such as prolyl hydroxylase (PHD or EglN), and an E3 ubiquitin ligase component for HIF degeneration called von Hippel-Lindau (encoding protein pVHL).	Oxygen	149-155	von Hippel-Lindau tumor suppressor	Homo sapiens	390-394
33178546-5	2020	Geometry-optimisation calculations using density functional theory reveal a geometry on CaF2(111) of nearly flat-lying PTCDA molecules with two oxygen atoms displaced towards calcium surface ions.	Oxygen	144-150	CCR4-NOT transcription complex subunit 8	Homo sapiens	88-92
33093455-3	2020	In addition, we found interleukin (IL)-1beta activity increased while IL-18 activity decreased in the retinas of oxygen-induced ischemic retinopathy (OIR) mice.	Oxygen	113-119	interleukin 18	Mus musculus	70-75
33067760-1	2021	PURPOSE: Conscious sedation by inhalation of a mixture of nitrous oxide and oxygen (CS) is a technique used in dental care for anxious, handicapped or uncooperative patients.	Oxygen	76-82	citrate synthase	Homo sapiens	84-86
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	chemokine (C-X-C motif) ligand 12	Mus musculus	158-163
33060735-7	2020	Likewise, the mRNA levels of TNFalpha and IL-1beta, reactive oxygen species, and the expression of MMP13 in the knee joints of TAP2-treated rats was significantly decreased by TAP2 treatment compared with the control.	Oxygen	61-67	transporter 2, ATP binding cassette subfamily B member	Rattus norvegicus	127-131
33060735-7	2020	Likewise, the mRNA levels of TNFalpha and IL-1beta, reactive oxygen species, and the expression of MMP13 in the knee joints of TAP2-treated rats was significantly decreased by TAP2 treatment compared with the control.	Oxygen	61-67	transporter 2, ATP binding cassette subfamily B member	Rattus norvegicus	176-180
33037242-6	2020	For comparison, right shift of ODC after VO2max test, representing the maximal physiological range to release oxygen to the tissue, indicated a p50 difference of up to 10 mmHg.	Oxygen	110-116	ornithine decarboxylase 1	Homo sapiens	31-34
32609042-12	2020	Sestrin2 was positively correlated with oxygen reduction index and negatively correlated with mean oxygen saturation and lowest oxygen saturation.	Oxygen	99-105	sestrin 2	Homo sapiens	0-8
33020645-1	2020	Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (ccRCC).	Oxygen	55-61	von Hippel-Lindau tumor suppressor	Homo sapiens	47-51
33020645-1	2020	Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (ccRCC).	Oxygen	55-61	von Hippel-Lindau tumor suppressor	Homo sapiens	48-51
33020645-4	2020	In this Perspective, we describe the understanding of the mechanisms of oxygen sensing and hypoxia signaling that resulted in the development of HIF2alpha-targeted therapies for patients with VHL-associated tumors.	Oxygen	72-78	von Hippel-Lindau tumor suppressor	Homo sapiens	192-195
32990599-6	2020	Consequently, COX6B2-expressing cancer cells display a proliferative advantage, particularly in low oxygen.	Oxygen	100-106	cytochrome c oxidase subunit 6B2	Homo sapiens	14-20
32845608-4	2020	Benefiting from the conductive and oxygen plasma activated CNTs as well as ordered and distributed metal sites in the framework, the optimized O-CNT/NiFe 1:18 exhibits the competitive overpotential of 279 mV at a current density of 10 mA cm-2 and a low Tafel slope of 42.8 mV dec-1 in 1.0 M KOH.	Oxygen	35-41	deleted in esophageal cancer 1	Homo sapiens	276-281
32565512-8	2020	KL-6 was also found to be significantly correlated with oxygenation index and oxygen partial pressure difference of alveolar artery (PA-aDO2) (Both P < 0.01).	Oxygen	56-62	mucin 1, cell surface associated	Homo sapiens	0-4
32844841-7	2020	At all conditions studied, the recombination of gamma-isobutanol radical with O2 forms HO2 + isobutanal.	Oxygen	78-80	heme oxygenase 2	Homo sapiens	87-90
32844841-8	2020	The recombination of beta-isobutanol radical with O2 forms a stabilized hydroperoxy alkyl radical below 400 K, water + an alkoxy radical at higher temperatures, and HO2 + an alkene above 1200 K. The recombination of beta-isobutanol radical with O2 results in a mixture of products between 700-1100 K, forming acetone + formaldehyde + OH at lower temperatures and forming HO2 + alkenes at higher temperatures.	Oxygen	50-52	heme oxygenase 2	Homo sapiens	165-168
32844841-8	2020	The recombination of beta-isobutanol radical with O2 forms a stabilized hydroperoxy alkyl radical below 400 K, water + an alkoxy radical at higher temperatures, and HO2 + an alkene above 1200 K. The recombination of beta-isobutanol radical with O2 results in a mixture of products between 700-1100 K, forming acetone + formaldehyde + OH at lower temperatures and forming HO2 + alkenes at higher temperatures.	Oxygen	50-52	heme oxygenase 2	Homo sapiens	371-374
32619679-14	2020	Furthermore, data from treatment of reactive oxygen species inhibitor N-acetyl-L-cysteine or NOXs inhibitor diphenyleneiodonium in fructose-exposed HepG2 cells showed that fructose enhanced NOX1, NOX2 and NOX4 expression to increase reactive oxygen species generation, causing oxidative stress and inflammation, more importantly, these disturbances were significantly attenuated by magnesium isoglycyrrhizinate.	Oxygen	45-51	NADPH oxidase 1	Homo sapiens	190-194
32743585-3	2020	Our prior studies in mice showed how high levels of oxygen (hyperoxia) between postnatal days 0-4 increases the severity of influenza A virus infections by reducing the number of alveolar epithelial type 2 (AT2) cells.	Oxygen	52-58	angiotensin II receptor type 2	Homo sapiens	207-210
32618988-5	2020	Typically, the obtained O-CoP nanorods with an optimal oxygen content exhibit excellent HER activity with an overpotential of 116 mV at a current density of 10 mA cm-2 and a small Tafel slope of 59 mV dec-1 in alkaline media.	Oxygen	55-61	deleted in esophageal cancer 1	Homo sapiens	201-206
32627769-10	2020	We propose a sequence of ion-molecule and radical reactions to explain the formation of O2-, HO2- and other ions observed in the negatively charged cluster ion series.	Oxygen	88-90	heme oxygenase 2	Homo sapiens	93-96
32788872-0	2020	Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.	Oxygen	72-78	caspase 12	Mus musculus	11-21
32342093-9	2020	In contrast, differences in binding energetics between SPD3+ and SPM4+ may arise from distinct electrostatic interactions between the polyamines and carboxylate oxygens on the side chains of E92 and E96, located in the pore-lining helix.	Oxygen	161-168	SPD3	Homo sapiens	55-59
33746081-12	2021	Patient"s characteristics that were associated with confirmed HF and high BNP levels were the following: presence of fatigue, night cough, elevated heart rate, shortness of breath, history of lung fibrosis and decreased oxygen arterial saturation (p < 0.05) Pulmonary hypertension, mitral and tricuspid regurgitation, and cor pulmonale were also associated with higher BNP levels.	Oxygen	220-226	natriuretic peptide B	Homo sapiens	74-77
32339710-4	2020	The incorporation of beta-CD-crHA significantly improved the surface hydrophilicity, water uptake ability, oxygen permeability, and flexibility of pHEMA hydrogel, but did not compromise light transmission.	Oxygen	107-113	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	21-28
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-50	heme oxygenase 2	Homo sapiens	35-38
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-50	heme oxygenase 2	Homo sapiens	175-178
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-50	heme oxygenase 2	Homo sapiens	175-178
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	36-38	heme oxygenase 2	Homo sapiens	175-178
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	36-38	heme oxygenase 2	Homo sapiens	175-178
32899535-3	2020	In this paper, we deposited AlON by sputtering AlN with O2, and we found that the variation of thickness of sputtered AlON NLs greatly influenced GaN growth on PSSs.	Oxygen	56-58	gigaxonin	Homo sapiens	146-149
32982696-3	2020	Here, we established an oxygen-glucose deprivation/reperfusion (OGD/R) model in rat primary cortical neurons and PC12 cells to explore the potential mechanism between RBM3 and SG formation in acute ischemic/reperfusion (I/R) condition.	Oxygen	24-30	RNA binding motif protein 3	Rattus norvegicus	167-171
32755449-4	2020	This inconsistency in the time course and severity of hearing and hair cell losses in Cx30-/- mice might be explained in part by an increase in reactive oxygen species generation beginning at postnatal day 10.	Oxygen	153-159	gap junction protein, beta 6	Mus musculus	86-90
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-48	heme oxygenase 2	Homo sapiens	35-38
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-48	heme oxygenase 2	Homo sapiens	175-178
33729637-3	2021	Looping Star has successfully demonstrated sensitivity to the cerebral blood-oxygen-level-dependent (BOLD) response during block design paradigms but has not been applied to event-related auditory perception tasks.	Oxygen	77-83	steroidogenic acute regulatory protein	Homo sapiens	8-12
32685808-6	2020	On the contrary, the reaction O3 + HO2 = OH + O2 + O2 has a significant effect on the explosion limit in the high-pressure and low-temperature region, as the concentration of HO2 increases through the rapid third-body reaction H + O2 + M = HO2 + M.	Oxygen	46-48	heme oxygenase 2	Homo sapiens	175-178
32569781-8	2020	CTRP1 was significantly upregulated in BV2 microglia exposed to oxygen and glucose deprivation and reperfusion (OGD/R).	Oxygen	64-70	C1q and TNF related 1	Homo sapiens	0-5
33683657-12	2021	Furthermore, suppressor of cytokine signaling 3 (SOCS3) mRNA was significantly decreased in rats and FATIICs exposed to oxygen, whereas it dramatically increased in FATIICs exposed to LPS.	Oxygen	120-126	suppressor of cytokine signaling 3	Rattus norvegicus	13-47
32601061-6	2020	We observed a substrate-bound B-type dinitrosyl iron center complex in ADO, suggesting the possibility of dioxygen binding to the iron ion in a side-on mode.	Oxygen	106-114	2-aminoethanethiol (cysteamine) dioxygenase	Mus musculus	71-74
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Oxygen	53-59	aurora kinase A	Homo sapiens	118-123
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Oxygen	53-59	aurora kinase A	Homo sapiens	286-291
33683657-12	2021	Furthermore, suppressor of cytokine signaling 3 (SOCS3) mRNA was significantly decreased in rats and FATIICs exposed to oxygen, whereas it dramatically increased in FATIICs exposed to LPS.	Oxygen	120-126	suppressor of cytokine signaling 3	Rattus norvegicus	49-54
32922298-5	2020	We further show that hypoxia-induced elevation of reactive oxygen species, but not the hypoxia-inducible factor, is responsible for the lipolysis and FGF21 expression.	Oxygen	59-65	fibroblast growth factor 21	Mus musculus	150-155
33904834-0	2021	Different regulation of IRE1alpha and eIF2alpha pathways by oxygen and insulin in ACH-3P trophoblast model.	Oxygen	60-66	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	24-33
31845160-4	2020	In this study, mice cortical neurons preconditioned with sublethal exposure to oxygen glucose deprivation (OGD) exhibited ATM/glucose-6-phosphate dehydrogenase pathway activation.	Oxygen	79-85	ataxia telangiectasia mutated	Mus musculus	122-125
31845160-6	2020	Meanwhile, we found that ATM/P53 pro-apoptosis pathway was driven by lethal OGD injury, and pharmacological inhibition of ATM during fatal oxygen-glucose deprivation/reperfusion injury promoted neuronal survival.	Oxygen	139-145	ataxia telangiectasia mutated	Mus musculus	122-125
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	48-54	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	75-84
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	61-63	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	75-84
34003380-0	2021	Simultaneous hyperbaric oxygen therapy during systemic chemotherapy reverses chemotherapy-induced peripheral neuropathy by inhibiting TLR4 and TRPV1 activation in the central and peripheral nervous system.	Oxygen	24-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-148
32077518-5	2020	The following lose-/gain-of-function assays demonstrated that CTRP6 knockdown significantly inhibited HG-induced reactive oxygen species (ROS) production in MCs.	Oxygen	122-128	C1q and TNF related 6	Homo sapiens	62-67
32475319-4	2020	Mito-ECFP/Ang II markedly increased oxygen consumption rate as an index of mitochondrial oxidative response (69.5%; P<0.01) and extracellular acidification rate as an index of mitochondrial glycolytic response (34%; P<0.01).	Oxygen	36-42	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	10-13
32475319-5	2020	The mito-ECFP/Ang II-induced oxygen consumption rate and extracellular acidification rate responses were blocked by AT1 blocker losartan (P<0.01) and a mitochondria-targeting superoxide scavenger mito-TEMPO (P<0.01).	Oxygen	29-35	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	14-17
32850832-9	2020	Thus, we concluded that the NLRP3/reactive oxygen species/HMGB1 pathway could be the underlying mechanism of ISO-induced cardiac fibrosis.	Oxygen	43-49	high mobility group box 1	Mus musculus	58-63
32339495-2	2020	The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).	Oxygen	25-31	von Hippel-Lindau tumor suppressor	Homo sapiens	386-403
32339495-2	2020	The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).	Oxygen	25-31	von Hippel-Lindau tumor suppressor	Homo sapiens	405-408
32492449-8	2020	Moreover, there were significant increase in the production of TP3-induced mitochondrial and cellular reactive oxygen species (ROS), as well as down-regulated mitochondrial oxygen consumption and extracellular acidification rates.	Oxygen	111-117	LOC100698624	Oreochromis niloticus	63-66
32492449-11	2020	TP3 promoted mitochondria-modulated intrinsic apoptosis through the induction of ROS production, activation of caspases 3/9, and the down-regulation of mitochondrial oxygen consumption and extracellular acidification rates, suggesting that TP3 has potential as an innovative alternative for OS treatment.	Oxygen	166-172	LOC100698624	Oreochromis niloticus	0-3
34015752-5	2021	In parallel, under prolonged iron deficiency, reactive oxygen species both inhibit FIT function and depend on FIT through the function of the catalase CAT2.	Oxygen	55-61	solute carrier family 7 member 2	Homo sapiens	151-155
32626926-5	2020	The results demonstrated that oxygen and glucose deprivation induced an increase in TXNIP expression, lactate dehydrogenase (LDH) release, caspase-3 activity, reactive oxygen species and malondialdehyde production.	Oxygen	30-36	caspase 3	Rattus norvegicus	139-148
32729912-0	2020	The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy.	Oxygen	43-49	apelin	Mus musculus	12-18
32565969-12	2020	Multiple drug resistance and levels of glutathione reductase can affect treatment efficacy through the increased efflux of anti-cancer drugs and weakening the effect of chemotherapy through the reduction of intracellular reactive oxygen species.	Oxygen	230-236	glutathione-disulfide reductase	Homo sapiens	39-60
33984166-6	2021	New insights on the structural and compositional design in MOF/MOG-derived oxygen electrocatalysts are summarized.	Oxygen	75-81	myelin oligodendrocyte glycoprotein	Homo sapiens	63-66
32360209-6	2020	The time constant of V  O2 (tau V  O2) was longer in OUT( 23.8 +- 2.4), MUT(25.4 +- 5.1), YUT(23.1 +- 3.4) than in YTR(16.2 +- 2.0), MTR(16.7 +- 3.9), OTR(16.3 +- 2.8) women (p < 0.05).	Oxygen	24-26	oxytocin receptor	Homo sapiens	151-154
31997812-0	2020	Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.	Oxygen	109-115	macrophage migration inhibitory factor	Homo sapiens	54-81
34026834-0	2021	Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells.	Oxygen	40-46	cytochrome c oxidase subunit 4I2	Homo sapiens	0-6
32691071-0	2020	Retraction: LncRNA MALAT1up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targeting miR-145.	Oxygen	129-135	angiopoietin 2	Homo sapiens	49-55
32579210-0	2020	Expression of Concern: LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targetting miR-145.	Oxygen	141-147	angiopoietin 2	Homo sapiens	61-67
33962950-6	2021	PRDX4 addiction is associated with increased reactive oxygen species, a DNA-PKcs-governed DNA damage response and radiosensitivity, which can be rescued by depletion of NOX4 or NADPH.	Oxygen	54-60	NADPH oxidase 4	Homo sapiens	169-173
32587277-4	2020	Here, we show that reduced levels of NTAL were associated with increased all-trans retinoic acid (ATRA)-induced differentiation, generation of reactive oxygen species, and mitochondrial dysfunction.	Oxygen	152-158	linker for activation of T cells family member 2	Homo sapiens	37-41
32732239-1	2020	Annotated genomes of Caballeronia strains SBC1 and SBC2 from acidic permafrost suggest a new species with a facultative lifestyle via oxygen and nitrate respiration.	Oxygen	134-140	solute carrier family 4 member 7	Homo sapiens	51-55
33640318-5	2021	Moreover, the expression of PKM2 was regulated by oxygen concentration in vitro.	Oxygen	50-56	pyruvate kinase, muscle	Mus musculus	28-32
32631054-6	2020	Furthermore, the obtained CoMoO4/MoO2 possesses excellent oxygen evolution performance, which is verified by an ultralow overpotential of 230 mV@10 mA cm-2, small Tafel slope (51 mV dec-1) and robust durability.	Oxygen	58-64	deleted in esophageal cancer 1	Homo sapiens	182-187
32458917-2	2020	A recent report of O2-dependent aliphatic C-C bond cleavage at ambient temperature in Ni(ii) diketonate complexes supported by a tridentate nitrogen donor ligand [(MBBP)Ni(PhC(O)CHC(O)Ph)]Cl (7-Cl; MBBP = 2,6-bis(1-methylbenzimidazol-2-yl)pyridine) in the presence of NEt3 spurred our interest in further examining the chemistry of such complexes.	Oxygen	19-21	tetraspanin 2	Homo sapiens	268-272
33965361-5	2021	RESULTS: A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission.	Oxygen	115-121	mucin 1, cell surface associated	Homo sapiens	53-57
32521756-7	2020	From the functional point of view, mitochondria from heterozygous MEF showed a lower oxygen consumption rate in basal conditions, either in the presence of glucose or galactose, and a reduced expression of mitochondrial complexes than wild type.	Oxygen	85-91	E74-like factor 4 (ets domain transcription factor)	Mus musculus	66-69
32312861-8	2020	The mPAP-CO slope was negatively correlated with the peak oxygen consumption (r=-0.45, p<0.001) and positively correlated with the minute ventilation versus carbon dioxide output slope (r=0.39, p<0.001).	Oxygen	58-64	phospholipid phosphatase 1	Mus musculus	4-8
32365411-1	2020	Mitochondrial affinity for oxygen was recently demonstrated to increase after sprint training and turned out to be closely associated with training-related improvement in pulmonary peak oxygen uptake (VO2peak) during both arm cranking and leg cycling1 .	Oxygen	27-33	cyclin G1	Homo sapiens	243-251
32365411-1	2020	Mitochondrial affinity for oxygen was recently demonstrated to increase after sprint training and turned out to be closely associated with training-related improvement in pulmonary peak oxygen uptake (VO2peak) during both arm cranking and leg cycling1 .	Oxygen	186-192	cyclin G1	Homo sapiens	243-251
32490656-3	2020	Such surface atom reorganization generates multiple crystalline-amorphous interfaces that benefit the kinetics of oxygen evolution reaction, achieving a low overpotential of only 261 mV at 10 mA cm 2 with a small Tafel slope of 41.13 mV dec 1.	Oxygen	114-120	deleted in esophageal cancer 1	Homo sapiens	237-242
32549692-15	2020	Conclusions: Our findings suggest that hip fracture patients who present with asymptomatic or mild COVID-19 infection may have temporarily increased oxygen demands postoperatively, but they can safely undergo early surgical intervention after appropriate medical optimization.	Oxygen	149-155	hedgehog interacting protein	Homo sapiens	39-42
32109696-2	2020	Ti/CNT/SnO2-Sb-Er with an ultra-high oxygen evolution potential (2.15 V) and enhanced electrocatalytic surface area was adopted as anode.	Oxygen	37-43	strawberry notch homolog 1	Homo sapiens	7-10
33965361-5	2021	RESULTS: A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission.	Oxygen	150-156	mucin 1, cell surface associated	Homo sapiens	53-57
31856334-0	2020	Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils.	Oxygen	45-51	interleukin 5	Homo sapiens	0-13
33855850-3	2021	In this study, we showed that the benzylic oxidation of PD is closely related to the formation of a benzylic semiquinone radical, which can be produced under two conditions: UV photoirradiation or catalysis by Plasmodium falciparum apicoplast ferredoxin-NADP+ reductase (PfFNR) redox cycling in the presence of oxygen and the parent PD.	Oxygen	311-317	ferredoxin reductase	Homo sapiens	243-269
31880165-2	2020	Cygb plays a critical role in the oxygen-dependent regulation of NO levels and vascular tone.	Oxygen	34-40	cytoglobin	Mus musculus	0-4
31880165-3	2020	CRITICAL ISSUES: Cygb is a more potent NO dioxygenase than previously known globins with structural differences in heme coordination and environment, conferring it with a higher rate of reduction and more rapid process of NO dioxygenation with unique oxygen dependence.	Oxygen	44-50	cytoglobin	Mus musculus	17-21
31880165-9	2020	The oxygen-dependent regulation of NO degradation by Cygb is also reviewed along with how Cygb paradoxically generates NO from nitrite under anaerobic conditions.	Oxygen	4-10	cytoglobin	Mus musculus	53-57
32377713-13	2020	In addition, in vitro results confirmed that alpha2M may protect cells from apoptosis and suppress reactive oxygen species accumulation.	Oxygen	108-114	alpha-2-macroglobulin	Rattus norvegicus	45-52
33745276-3	2021	The alkoxo oxygens of the two eta1:eta2:eta1-(py)2C(CH2NO2)(O)- ligands doubly bridge the InIII centers and create a {In2(mu2-OR)2}4+ core.	Oxygen	11-18	DNA polymerase iota	Homo sapiens	35-39
31916414-1	2020	AIMS: Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.	Oxygen	165-171	xanthine dehydrogenase	Homo sapiens	100-123
31916414-1	2020	AIMS: Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.	Oxygen	165-171	xanthine dehydrogenase	Homo sapiens	125-128
32338336-6	2020	Following oxygen and glucose deprivation (OGD) in SH-SY5Y cells, the mitochondrial AIF was translocated into nucleus after 12 h. The co-immunoprecipitation analysis showed that the interaction between AIF and MIF was activated by OGD and subsequently resulted in MIF nuclear translocation.	Oxygen	10-16	macrophage migration inhibitory factor	Homo sapiens	209-212
32338336-6	2020	Following oxygen and glucose deprivation (OGD) in SH-SY5Y cells, the mitochondrial AIF was translocated into nucleus after 12 h. The co-immunoprecipitation analysis showed that the interaction between AIF and MIF was activated by OGD and subsequently resulted in MIF nuclear translocation.	Oxygen	10-16	macrophage migration inhibitory factor	Homo sapiens	263-266
33749882-4	2021	Targeted deletion of Mfn2 gene in myoblasts (Mfn2MKO ) increases oxygen-consumption rates (OCR) associated with the maximal respiration and spare respiratory capacity, and increased levels of reactive oxygen species (ROS).	Oxygen	65-71	mitofusin 2	Mus musculus	21-25
31958442-3	2020	Few small randomized controlled trials (RCTs) have shown statistically significant and clinically important reduction in sympathetic activity when CSA/HCSB is attenuated by oxygen or positive airway pressure (PAP) therapy, both continuous PAP (CPAP) and Adaptive servo ventilation (ASV) devices.	Oxygen	173-179	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	147-150
32274893-10	2020	Thus, treatment of insulin resistant patients with GLP-1 receptor agonists may improve skeletal and cardiac muscle microvascular perfusion and increase muscle capillarization, leading to improved delivery of oxygen, nutrients, and hormones such as insulin to the myocytes.	Oxygen	208-214	glucagon like peptide 1 receptor	Homo sapiens	51-65
32201278-9	2020	Meanwhile, CuONPs downregulated expression of O2--eliminating enzyme NOX4 both at mRNA and protein levels, but did not affect the expression of SOD2 and catalase.	Oxygen	46-48	NADPH oxidase 4	Homo sapiens	69-73
33071240-6	2021	In animals, TRPM8 agonism increases basal metabolic rate, non-shivering thermogenesis, oxygen consumption, exercise endurance, and fatty acid oxidation and decreases abdominal fat percentage.	Oxygen	87-93	transient receptor potential cation channel subfamily M member 8	Homo sapiens	12-17
32201278-10	2020	NOX4 knockdown caused more accumulation of O2-, and a further decrease of H2O2 in CuONPs-treated HUVECs, suggesting that NOX4 regulates the conversion of O2- to H2O2 in CuONPs-treated HUVECs.	Oxygen	43-46	NADPH oxidase 4	Homo sapiens	0-4
32201278-10	2020	NOX4 knockdown caused more accumulation of O2-, and a further decrease of H2O2 in CuONPs-treated HUVECs, suggesting that NOX4 regulates the conversion of O2- to H2O2 in CuONPs-treated HUVECs.	Oxygen	43-46	NADPH oxidase 4	Homo sapiens	121-125
32201278-10	2020	NOX4 knockdown caused more accumulation of O2-, and a further decrease of H2O2 in CuONPs-treated HUVECs, suggesting that NOX4 regulates the conversion of O2- to H2O2 in CuONPs-treated HUVECs.	Oxygen	43-45	NADPH oxidase 4	Homo sapiens	0-4
32201278-10	2020	NOX4 knockdown caused more accumulation of O2-, and a further decrease of H2O2 in CuONPs-treated HUVECs, suggesting that NOX4 regulates the conversion of O2- to H2O2 in CuONPs-treated HUVECs.	Oxygen	43-45	NADPH oxidase 4	Homo sapiens	121-125
31958442-9	2020	Most recently, the NIH funded a long-term, phase-III RCT of low flow oxygen vs. sham for the treatment of CSA/HCSB in HFrEF.	Oxygen	69-75	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	106-109
31990992-0	2020	Inhibition of microRNA-199a-5p ameliorates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO-1 signaling.	Oxygen	43-49	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	152-156
33791717-5	2021	Large infiltrates by Arginase 1 + G-MDSC (Arg + G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen species) were found in the lungs of patients who died from COVID-19 complications.	Oxygen	122-128	arginase 1	Homo sapiens	21-31
31961204-11	2020	miR-137 overexpression can reduce oxygen-glucose deprivation (OGD)/R-induced cell damage, improve cell proliferation, and reduce apoptotic rate.	Oxygen	34-40	microRNA 137	Rattus norvegicus	0-7
31903559-1	2020	NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as autophagy dysregulation and increased reactive oxygen species production stimulating inflammation by priming the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 in their active form.	Oxygen	131-137	NLR family pyrin domain containing 3	Bos taurus	0-5
31903559-1	2020	NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as autophagy dysregulation and increased reactive oxygen species production stimulating inflammation by priming the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 in their active form.	Oxygen	131-137	interleukin 1 beta	Bos taurus	237-254
31654225-4	2020	In this study, we have shown that DEX and DEX + RAPA (autophagy inducer) increased viability and reduced apoptosis of primary astrocytes in oxygen-glucose deprivation (OGD) model compared with DEX + 3-methyladenine (3-MA) (autophagy inhibitor).	Oxygen	140-146	transcriptional regulating factor 1	Homo sapiens	48-52
32189529-7	2020	In ADSCs, LIF was upregulated in both oxygen concentrations, whereas Angpt1 was upregulated only at 1% O2.	Oxygen	103-105	angiopoietin 1	Homo sapiens	69-75
32637980-9	2020	Conversely, because the N-terminus of AE1 stabilizes deoxyhemoglobin and finely tunes oxygen off-loading, RBCs from COVID-19 patients may be incapable of responding to environmental variations in hemoglobin oxygen saturation when traveling from the lungs to peripheral capillaries and, as such, may have a compromised capacity to transport and deliver oxygen.	Oxygen	86-92	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	38-41
32606431-9	2020	Spexin levels significantly increased only in responders to exercise (those with increased oxygen consumption, VO2 max) with a concomitant improvement in metabolic profile.	Oxygen	91-97	spexin hormone	Homo sapiens	0-6
32560750-1	2020	Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations.	Oxygen	157-163	viral integration site 1	Homo sapiens	50-55
33791717-5	2021	Large infiltrates by Arginase 1 + G-MDSC (Arg + G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen species) were found in the lungs of patients who died from COVID-19 complications.	Oxygen	122-128	NADPH oxidase 1	Homo sapiens	68-73
32201313-4	2020	ERO1 recycles reduced PDI family member PDIA1 using a FAD cofactor to transfer electrons to oxygen.	Oxygen	92-98	prolyl 4-hydroxylase subunit beta	Homo sapiens	22-25
32201313-4	2020	ERO1 recycles reduced PDI family member PDIA1 using a FAD cofactor to transfer electrons to oxygen.	Oxygen	92-98	prolyl 4-hydroxylase subunit beta	Homo sapiens	40-45
33481326-0	2021	Delivering the Full Potential of Oxygen Evolving Electrocatalyst by Conditioning Electrolytes at Near-Neutral pH.	Oxygen	33-39	phenylalanine hydroxylase	Homo sapiens	110-112
33550096-2	2021	Oxygen-dependent hydroxylation of HIF-1alpha is tightly regulated by prolyl hydroxylase domain containing proteins (PHD1, PHD2, and PHD3).	Oxygen	0-6	egl-9 family hypoxia inducible factor 2	Homo sapiens	116-120
32213636-4	2020	We show that RPT2 suppresses the activity of phot1 and demonstrate that RPT2 binds to the PHOT1 LOV1 (light, oxygen or voltage sensing 1) domain which is required for its high photosensitivity.	Oxygen	109-115	phototropin 1	Arabidopsis thaliana	45-50
32493757-5	2020	IH-dependent HIF1a signaling caused a two-fold increase in expression of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4).	Oxygen	86-92	NADPH oxidase 4	Mus musculus	119-134
32493757-5	2020	IH-dependent HIF1a signaling caused a two-fold increase in expression of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4).	Oxygen	86-92	NADPH oxidase 4	Mus musculus	136-140
33656879-5	2021	For CYP17A1 with 17OH-PROG, a characteristic shift of the Fe-O mode is observed in the presence of Mn-b5, indicating reorientation of a hydrogen bond between the 17OH group of the substrate from the terminal to the proximal oxygen atom of the Fe-O-O moiety, a configuration favorable for the lyase catalysis.	Oxygen	224-230	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	4-11
32575797-2	2020	Whilst underlying pathways are incompletely understood, increased reactive oxygen species generation from Nox2 NADPH oxidases, and metabolic remodelling, largely driven by PPARalpha downregulation, are separately implicated.	Oxygen	75-81	cytochrome b-245, beta polypeptide	Mus musculus	106-110
32575551-2	2020	Catalase is an antioxidant enzyme that plays a significant role in cellular protection against oxidative damage by the degradation of hydrogen peroxide to oxygen and water.	Oxygen	155-161	catalase	Bos taurus	0-8
32368889-4	2020	The more oxygen vacancy concentration in the anode, the higher discharge capacity in the LIB.	Oxygen	9-15	leucine rich repeat containing 15	Homo sapiens	89-92
32434995-4	2020	Unbiased high-throughput metabolic profiling coupled with in vitro and in vivo flux analyses with isotopically labeled tracers led us to discover that maternal eENT1-dependent adenosine uptake is critical in activating AMPK by controlling the AMP/ATP ratio and its downstream target, bisphosphoglycerate mutase (BPGM); in turn, BPGM mediates 2,3-BPG production, which enhances O2 delivery to maintain placental oxygenation.	Oxygen	377-379	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	219-223
33485889-2	2021	Herein, a good oxygen barrier composite film with desired mechanical properties was prepared based on carboxymethly xylan (CMX), chitosan (CS), and graphene oxide (GO).	Oxygen	15-21	citrate synthase	Homo sapiens	139-141
32478052-5	2020	By analyzing the molecular mechanism associated with its functions, we found that let-7i-5p regulates through its direct target genes involved in collagen metabolism, cell proliferation and differentiation, TGF-beta signaling, DNA repair and ubiquitination, gene silencing and oxygen homeostasis.	Oxygen	277-283	microRNA let-7i	Homo sapiens	82-88
32595647-6	2020	Here we demonstrate that in primary human neutrophils, Cdc42 controls directed and random migration, activation, and degranulation as well as the formation of reactive oxygen species, in a stimulus dependent manner.	Oxygen	168-174	cell division cycle 42	Homo sapiens	55-60
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Oxygen	375-381	LOC100508689	Homo sapiens	4-9
32406228-8	2020	Taking advantage of the tunable fluorescence, inherent porosity, and high chemical stability of this MOF platform, it was applied as a fluorescent sensor for oxygen detection in the gas phase, a model reaction, showing fast response and good recyclability.	Oxygen	158-164	lysine acetyltransferase 8	Homo sapiens	101-104
32152006-7	2020	Our results indicate that D. simulans and D. melanogaster mtDNA haplotypes display opposite Sirt4-mediated phenotypes in the regulation of whole-fly oxygen consumption.	Oxygen	149-155	Sirtuin 4	Drosophila melanogaster	92-97
32159384-10	2020	With 0-20 ppmv O2 in CH4/CO2/N2 mixtures, ions contain mostly organic nitrogen, with CNO- being the most intense ion peak.	Oxygen	15-17	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	85-88
32366527-3	2020	Their work suggests a role for stromally expressed NADPH oxidase 4 (NOX4) as a modulator of reactive oxygen species that in turn can reduce the number of CD8+ T cells locally.	Oxygen	101-107	NADPH oxidase 4	Homo sapiens	51-66
32366527-3	2020	Their work suggests a role for stromally expressed NADPH oxidase 4 (NOX4) as a modulator of reactive oxygen species that in turn can reduce the number of CD8+ T cells locally.	Oxygen	101-107	NADPH oxidase 4	Homo sapiens	68-72
32581712-8	2020	Overexpression or knockdown of METTL3 in oxygen-glucose deprivation of PC12 cells resulted in functional maturation of miR-335, SG formation and apoptosis levels.	Oxygen	41-47	microRNA mir-335	Rattus norvegicus	119-126
32383263-0	2020	Transcription Factor ArcA is a Flux Sensor for the Oxygen Consumption Rate in Escherichia coli.	Oxygen	51-57	arginine deiminase	Escherichia coli	21-25
32383263-5	2020	Therefore, the present study, is focused on the role of the transcription factor ArcA in the oxygen response of E. coli and investigated the relationship between ArcA activity and the oxygen consumption rate.	Oxygen	93-99	arginine deiminase	Escherichia coli	81-85
31957488-2	2020	Ang II treatment decreased HUVEC viability, increased cell apoptosis, decreased mitochondria membrane potential (MMP), impaired cytochrome c release, activated caspase 3/9, and induced reactive oxygen species (ROS) production, and nicotinamide adenine dinucleotide phosphate oxidase activity.	Oxygen	194-200	angiogenin	Homo sapiens	0-3
32383263-5	2020	Therefore, the present study, is focused on the role of the transcription factor ArcA in the oxygen response of E. coli and investigated the relationship between ArcA activity and the oxygen consumption rate.	Oxygen	184-190	arginine deiminase	Escherichia coli	162-166
33776928-12	2021	Ex vitro experiments further revealed that hIRX3 overexpression induced by Ucp1-driven Cre recombinase activity upregulated brown/beige adipocytes Ucp1 expression and oxygen consumption rate (OCR).	Oxygen	167-173	iroquois homeobox 3	Homo sapiens	43-48
32383263-8	2020	Although there is no correlation between ArcA activity and dissolved oxygen concentration, a strong negative correlation between ArcA activity and the specific oxygen consumption rate (R2 > 0.93) is observed.	Oxygen	160-166	arginine deiminase	Escherichia coli	129-133
32188693-4	2020	Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species-producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator.	Oxygen	197-203	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	37-43
33776928-12	2021	Ex vitro experiments further revealed that hIRX3 overexpression induced by Ucp1-driven Cre recombinase activity upregulated brown/beige adipocytes Ucp1 expression and oxygen consumption rate (OCR).	Oxygen	167-173	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	75-79
33635334-2	2021	beta-globin associates with alpha-globin to form adult hemoglobin (HbA, alpha2beta2), the main oxygen-carrier in erythrocytes.	Oxygen	95-101	hemoglobin subunit alpha 2	Homo sapiens	28-40
31669521-2	2020	Transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply.	Oxygen	228-234	cellular communication network factor 2	Homo sapiens	47-78
31669521-2	2020	Transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply.	Oxygen	228-234	cellular communication network factor 2	Homo sapiens	80-84
31669521-2	2020	Transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply.	Oxygen	228-234	cellular communication network factor 2	Homo sapiens	85-89
31935492-2	2020	We have previously shown that the application of the mGluR1/5 agonist (S)-3,5-dihydroxyphenylglycine (DHPG) 5 min after 30 min of oxygen and glucose deprivation (OGD) reduces CA1 damage in organotypic hippocampal slices by activating the PI3K-Akt signalling pathway.	Oxygen	130-136	glutamate metabotropic receptor 1	Homo sapiens	53-59
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Oxygen	58-64	coproporphyrinogen oxidase	Homo sapiens	105-108
32291341-3	2020	Recent studies have revealed, in normoxic growth conditions, an interface made exclusively by Cox5A, the only yeast respiratory protein that exists as one of two isoforms depending on oxygen levels.	Oxygen	184-190	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	94-99
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Oxygen	212-218	coproporphyrinogen oxidase	Homo sapiens	105-108
33744681-6	2021	Amperometric investigations revealed low reductive current densities, i.e. about 1.65 microA cm-2 in oxygenated electrolyte and in the absence of any mediator, demonstrating nevertheless direct electron transfer based O2 bioelectroreduction by HCp for the first time.	Oxygen	218-220	coproporphyrinogen oxidase	Homo sapiens	244-247
33387446-2	2021	Here we use density functional theory (DFT) to study SAAs comprised of Ni, Pd, Pt, Co and Rh doped into Ag and Au hosts, as candidate electrocatalysts for the oxygen reduction reaction (ORR) in proton-exchange membrane (PEM) fuel-cells.	Oxygen	159-165	mucin 1, cell surface associated	Homo sapiens	220-223
31746324-5	2020	In the case of nNOS-interneurons, robust hemodynamic changes occurred with minimal changes in neural activity, suggesting that the ability of blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) to reliably reflect changes in neuronal activity may be dependent on type of neuron recruited.	Oxygen	148-154	nitric oxide synthase 1, neuronal	Mus musculus	15-19
33436225-4	2021	CRG exhibited improved degree of order and reduced graphitization defect, N-5 and OI groups were the dominant nitrogen and oxygen-containing groups.	Oxygen	123-129	chromodomain helicase DNA binding protein 7	Homo sapiens	0-3
32176869-0	2020	Investigation of the growth of few-layer SnS2 thin films via atomic layer deposition on an O2 plasma-treated substrate.	Oxygen	91-93	sodium voltage-gated channel alpha subunit 11	Homo sapiens	41-45
32176869-7	2020	Thus, the ALD-grown SnS2 thin film on the SiO2 substrate treated with O2 plasma was thicker than the film grown on the non-treated SiO2 substrate.	Oxygen	44-46	sodium voltage-gated channel alpha subunit 11	Homo sapiens	20-24
33432238-5	2021	This is surprising, as enzymes of the flavin-containing amine oxidase family were invariably thought to use O2 as an electron acceptor.	Oxygen	108-110	spermine oxidase	Homo sapiens	38-69
32186181-7	2020	The binding energy of O2 to neutral UO2 in a eta2 orientation was calculated to be very strong, 75.4 kcal/mol, and strongly resembled a UO2+(O2-) complex at equilibrium.	Oxygen	22-24	DNA polymerase iota	Homo sapiens	45-49
32186181-7	2020	The binding energy of O2 to neutral UO2 in a eta2 orientation was calculated to be very strong, 75.4 kcal/mol, and strongly resembled a UO2+(O2-) complex at equilibrium.	Oxygen	37-39	DNA polymerase iota	Homo sapiens	45-49
31705296-8	2020	HbA1c and global RV endocardial longitudinal strain were independently associated with peak VO2 and oxygen pulse in the whole study population.	Oxygen	100-106	hemoglobin subunit alpha 1	Homo sapiens	0-4
33045408-4	2021	At concentrations <= 2.5 mM, metformin significantly increased oxygen consumption rate (OCR) in the hiPSC-CMs by activating AMPK-dependent signaling and enhancing mitochondrial biogenesis.	Oxygen	63-69	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	124-128
32142210-3	2020	A small number of PLP-dependent enzymes employ molecular oxygen as a co-substrate.	Oxygen	57-63	pyridoxal phosphatase	Homo sapiens	18-21
32226477-4	2020	Results: Our results demonstrated that human IAPP induced mitochondrial dysfunction, as evidence by loss of DeltaPsim and ATP content, and decrease in oxygen consumption and complex activities, was accompanied by JNK activation, changes in the expressions of Bcl-2 and Bax proteins, release of cytochrome c (Cyto-c) and apoptosis inducing factor (AIF) from mitochondria into cytosol.	Oxygen	151-157	islet amyloid polypeptide	Homo sapiens	45-49
33279623-5	2021	CD45+CD71+ erythroid cells suppressed T cells through generation of reactive oxygen species, IL-10, and TGF-beta in a paracrine and cell-cell contact manner, and their suppressive effect was stronger than that of myeloid-derived suppressor cells.	Oxygen	77-83	transferrin receptor	Homo sapiens	5-9
32058685-6	2020	Actually, oxygen atoms that are unexpectedly detached from HCHO molecules are found to fill the vacancies, giving rise to p-type doping in SnS2.	Oxygen	10-16	sodium voltage-gated channel alpha subunit 11	Homo sapiens	139-143
33708138-6	2021	We exposed Gansu zokors and rats to hypoxia I (44 h at 10.5% O2) or hypoxia II (6 h at 6.5% O2) and then measured the transcriptional levels of mTORC1 downstream targets, the transcriptional and translational levels of glycolysis-related genes, glucose and fructose levels in plasma and brain, and the activity of key glycolysis-associated enzymes.	Oxygen	92-94	CREB regulated transcription coactivator 1	Mus musculus	144-150
32152380-6	2020	SH-SY5Y cells were transfected with a specific inhibitor of miR-335-5p and showed abnormal mitochondrial morphology, with an increment of reactive species of oxygen and superoxide dismutase activity.	Oxygen	158-164	microRNA 335	Homo sapiens	60-67
33418107-7	2021	Through electrochemical and spectral studies, NOD f3 was found to exhibit good biocompatibility and high reduction efficiency and its potentials in cell-protection in oxygen and glucose deprivation (OGD) models were showcased with endothelial cells.	Oxygen	167-173	atrophin 1	Homo sapiens	46-49
31904285-9	2020	AT1 receptor inhibition did not affect the response to Ang II, whereas AT2 receptor inhibition abolished the response in mitochondria from control animals and reversed the response to increased oxygen consumption through superoxide-induced mitochondrial uncoupling in mitochondria from diabetic rat.	Oxygen	194-200	angiotensin II receptor, type 2	Rattus norvegicus	71-74
33441441-3	2021	FACS-sorted lung eosinophils from TPE mice exhibited aiPLA2-dependent activation characterized by heavy calcium influx, F-actin polymerization, increased degranulation, and heightened reactive oxygen species generation.	Oxygen	193-199	peroxiredoxin 6	Mus musculus	53-59
31813325-0	2020	Hyperbaric oxygen suppresses stemness-associated properties and Nanog and oncostatin M expression, but upregulates beta-catenin in orthotopic glioma models.	Oxygen	11-17	oncostatin M	Homo sapiens	74-86
33593593-3	2021	Here, we highlight recently uncovered mechanisms linking amino acid, glucose, and oxygen levels to autophagy regulation through mTORC1 and AMPK.	Oxygen	82-88	CREB regulated transcription coactivator 1	Mus musculus	128-134
32006081-4	2020	We hypothesized that peak oxygen consumption ([Formula: see text]) would be decreased, in association with elevated mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVRi).	Oxygen	26-32	phospholipid phosphatase 1	Mus musculus	148-152
33593593-3	2021	Here, we highlight recently uncovered mechanisms linking amino acid, glucose, and oxygen levels to autophagy regulation through mTORC1 and AMPK.	Oxygen	82-88	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	139-143
33628390-4	2021	Consistently, the 50% oxygen saturation (P50) value was increased in erythrocytes of Cse -/- mice.	Oxygen	22-28	cystathionase (cystathionine gamma-lyase)	Mus musculus	85-88
32185076-8	2020	5"-Adenosine monophosphate-activated protein kinase (AMPK), as a kinase, is not only an energy modulator but also a sensor of cellular oxygen-reduction substances, and many researches have suggested that AMPK plays an essential role in revascularization but the mechanism is not completely understood.	Oxygen	135-141	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	53-57
33580173-2	2021	XOR also enhances the production of reactive oxygen species and causes endothelial dysfunction.	Oxygen	45-51	xanthine dehydrogenase	Homo sapiens	0-3
32185076-8	2020	5"-Adenosine monophosphate-activated protein kinase (AMPK), as a kinase, is not only an energy modulator but also a sensor of cellular oxygen-reduction substances, and many researches have suggested that AMPK plays an essential role in revascularization but the mechanism is not completely understood.	Oxygen	135-141	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	204-208
32963203-1	2021	Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell.	Oxygen	57-63	glycogen synthase kinase 3 beta	Rattus norvegicus	12-14
32080237-9	2020	Similarly, C2C12 myoblasts show a reduced oxygen consumption rate mediated by Pi transport-dependent and ERK1/2-dependent metabolic Pi sensing pathways.	Oxygen	42-48	mitogen-activated protein kinase 3	Mus musculus	105-111
32179514-7	2020	Eventually, increased reactive oxygen species and mitochondrial structural damage was observed in GPD1-overexpressing cell lines treated with metformin, which may contribute to cell death.	Oxygen	31-37	glycerol-3-phosphate dehydrogenase 1	Homo sapiens	98-102
32490521-5	2020	Metabolic reactions linked to arginase were also affected, since urease-positive and urease-negative cells differed with respect to agmatinase activity, polyamine synthesis, as well as intracellular levels of proline and reactive oxygen species.	Oxygen	230-236	urease	Cryptococcus neoformans var. grubii H99	85-91
33557324-2	2021	Quasi-reversible O2/O2 - redox was found to be modified by the compounds, suggesting that an acid-base reaction in which a hydroperoxyl radical (HO2 ) is formed from O2 - occurs.	Oxygen	17-19	heme oxygenase 2	Homo sapiens	145-148
32528056-5	2020	Moreover, increased levels of reactive oxygen species in the Sestrin2-deficient corneal epithelium promote the nuclear localization and dephosphorylation of YAP, activating it to enhance the proliferation of corneal epithelial cells.	Oxygen	39-45	yes-associated protein 1	Mus musculus	157-160
32093119-0	2020	NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity.	Oxygen	36-42	cytochrome b-245, beta polypeptide	Mus musculus	0-15
33557324-2	2021	Quasi-reversible O2/O2 - redox was found to be modified by the compounds, suggesting that an acid-base reaction in which a hydroperoxyl radical (HO2 ) is formed from O2 - occurs.	Oxygen	20-22	heme oxygenase 2	Homo sapiens	145-148
31887381-9	2020	In vivo, Rap-1 decreased the ROS and O2- levels and recovered the heart in zebrafish (Danio rerio) larvae induced by LPS, These results together suggested that Rap-1 could be a potential functional resource to protect against inflammatory and oxidative damage.	Oxygen	37-40	RAS-related protein 1a	Mus musculus	9-14
31887381-9	2020	In vivo, Rap-1 decreased the ROS and O2- levels and recovered the heart in zebrafish (Danio rerio) larvae induced by LPS, These results together suggested that Rap-1 could be a potential functional resource to protect against inflammatory and oxidative damage.	Oxygen	37-40	RAS-related protein 1a	Mus musculus	160-165
32075102-2	2020	The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms COX4i1 and COX4i2.	Oxygen	80-86	cytochrome c oxidase subunit 4I1	Homo sapiens	4-8
32075102-2	2020	The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms COX4i1 and COX4i2.	Oxygen	80-86	cytochrome c oxidase subunit 4I1	Homo sapiens	125-131
32278565-7	2020	Whereas MFN2 knockdown potentiated the FFA-induced activation of these inflammatory pathways, overexpression of MFN2 attenuated the detrimental effect of excess exogenous FFA by improving mitochondrial function and decreasing the release of reactive oxygen species, suggesting that MFN2 may be a potential therapeutic target for FFA-induced hepatic inflammation in dairy cows during early lactation.	Oxygen	250-256	mitofusin 2	Bos taurus	112-116
32278565-7	2020	Whereas MFN2 knockdown potentiated the FFA-induced activation of these inflammatory pathways, overexpression of MFN2 attenuated the detrimental effect of excess exogenous FFA by improving mitochondrial function and decreasing the release of reactive oxygen species, suggesting that MFN2 may be a potential therapeutic target for FFA-induced hepatic inflammation in dairy cows during early lactation.	Oxygen	250-256	mitofusin 2	Bos taurus	112-116
31903618-13	2020	Findings suggest that TMJ loading that induces persistent sensitivity upregulates the catabolic factor HIF-2alpha and reduces oxygen levels in the cartilage, which may be TNF-driven.	Oxygen	126-132	tumor necrosis factor-like	Rattus norvegicus	171-174
32075102-2	2020	The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms COX4i1 and COX4i2.	Oxygen	80-86	cytochrome c oxidase subunit 4I2	Homo sapiens	136-142
33557324-2	2021	Quasi-reversible O2/O2 - redox was found to be modified by the compounds, suggesting that an acid-base reaction in which a hydroperoxyl radical (HO2 ) is formed from O2 - occurs.	Oxygen	20-22	heme oxygenase 2	Homo sapiens	145-148
32075102-10	2020	Most remarkable changes were uncovered in COX oxygen kinetics.	Oxygen	46-52	cytochrome c oxidase subunit 8A	Homo sapiens	42-45
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	29-35	cytochrome c oxidase subunit 4I2	Homo sapiens	90-96
33557191-9	2021	The peak of SPR, which is the emission intensity change with respect to normalized pressure fluctuation, appears at a lower partial pressure of oxygen than that of Blocal.	Oxygen	144-150	sepiapterin reductase	Homo sapiens	12-15
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	29-35	cytochrome c oxidase subunit 4I1	Homo sapiens	104-110
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	29-35	cytochrome c oxidase subunit 4I2	Homo sapiens	162-168
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	139-145	cytochrome c oxidase subunit 4I2	Homo sapiens	90-96
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	139-145	cytochrome c oxidase subunit 4I1	Homo sapiens	104-110
32075102-11	2020	The p50 (partial pressure of oxygen at half-maximal respiration) was increased twofold in COX4i2 versus COX4i1 cells, indicating decreased oxygen affinity of the COX4i2-containing enzyme.	Oxygen	139-145	cytochrome c oxidase subunit 4I2	Homo sapiens	162-168
32443983-8	2020	The use of endothelial cells to vascularize hPSC-derived organoids may represent a key to ensuring oxygen and nutrient distribution in large organoids, thus contributing to the maturation of adult-like organoids through paracrine signaling.Here, we review the current state of the art regarding vascularized hPSC-derived organoids (vhPSC-Orgs).	Oxygen	99-105	PSC	Homo sapiens	44-48
33356389-7	2021	AIBP expression was necessary for efficient control of reactive oxygen species and cell death and for mitochondria quality control in macrophages exposed to OxLDL.	Oxygen	64-70	NAD(P)HX epimerase	Mus musculus	0-4
32548435-0	2020	A-Site Cation-Ordering Layered Perovskite EuBa0.5Sr0.5Co2-x Fe x O5+delta as Highly Active and Durable Electrocatalysts for Oxygen Evolution Reaction.	Oxygen	124-130	immunoglobulin kappa variable 2D-36 (pseudogene)	Homo sapiens	65-73
32050585-9	2020	Ang-(1-7) also abolished the increase of myostatin-induced reactive oxygen species production, atrogin-1, MuRF-1, and TNF-alpha gene expressions and NF-kappaB signaling activation.	Oxygen	68-74	angiogenin	Homo sapiens	0-3
33360083-6	2021	O2- /HO2  and  OH were responsible for the cathodic TC degradation.	Oxygen	0-2	heme oxygenase 2	Homo sapiens	5-8
32046324-7	2020	p38 MAPK contributed to Akt-induced eNOS phosphorylation at Ser1177 that resulted in accelerated NO production and reduced reactive oxygen species production in aortic endothelia.	Oxygen	132-138	mitogen-activated protein kinase 14	Mus musculus	0-3
32424179-8	2020	In vitro, S1PR2 participates in the redirection of neutrophil apoptosis to NETosis via Galphai/o, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and reactive oxygen species signaling pathways.	Oxygen	188-194	sphingosine-1-phosphate receptor 2	Mus musculus	10-15
33002687-3	2021	It is found that this hollow C@SnS2/SnS nanocomposite can serve as electrocatalyst, showing excellent oxygen evolution reaction performance.	Oxygen	102-108	sodium voltage-gated channel alpha subunit 11	Homo sapiens	31-35
32068847-5	2020	Moreover, T61I CHCHD2 induced increased mitochondrial production of reactive oxygen species (ROS) and apoptosis, which was prevented by treatment with anti-oxidants.	Oxygen	77-83	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	15-21
31987329-6	2020	In deer, there was a greater abundance of SOD2 mRNA transcript (P < 0.05) when oocytes had been matured under relatively lesser O2, regardless of the tension used during fertilization.	Oxygen	128-130	superoxide dismutase [Mn], mitochondrial	Ovis aries	42-46
33338600-5	2021	In a hyperoxia-based animal model of BPD, oxygen exposure deregulated MPST expression during post-natal lung development, where MPST was localized to the smooth muscle layer of the pulmonary vessels in developing lungs.	Oxygen	42-48	mercaptopyruvate sulfurtransferase	Homo sapiens	70-74
31862654-0	2020	Downregulation of TRIM8 protects neurons from oxygen-glucose deprivation/re-oxygenation-induced injury through reinforcement of the AMPK/Nrf2/ARE antioxidant signaling pathway.	Oxygen	46-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	132-136
31786316-2	2020	Kynurenine is now known to signal through the aryl hydrocarbon receptor (Ahr) to modulate levels of reactive oxygen species (ROS).	Oxygen	109-115	aryl hydrocarbon receptor	Homo sapiens	46-71
31786316-2	2020	Kynurenine is now known to signal through the aryl hydrocarbon receptor (Ahr) to modulate levels of reactive oxygen species (ROS).	Oxygen	109-115	aryl hydrocarbon receptor	Homo sapiens	73-76
31862067-3	2020	The potential roles of Lewis acid sites (activating dioxygen) were discussed, and the experimental results indicated that the most efficient route for toluene degradation over Cu0.7Mn2Ce0.3Ox/HTS-1 (toluene conversion rate of 90% (T99)=295 C) was ascribed to regulation of the synergistic effects of redox properties (activating molecular toluene) and Lewis acid sites (activating dioxygen).	Oxygen	52-60	DENN domain containing 2B	Homo sapiens	192-197
31862067-3	2020	The potential roles of Lewis acid sites (activating dioxygen) were discussed, and the experimental results indicated that the most efficient route for toluene degradation over Cu0.7Mn2Ce0.3Ox/HTS-1 (toluene conversion rate of 90% (T99)=295 C) was ascribed to regulation of the synergistic effects of redox properties (activating molecular toluene) and Lewis acid sites (activating dioxygen).	Oxygen	381-389	DENN domain containing 2B	Homo sapiens	192-197
32255634-7	2020	The main products (and associated relative abundances) originating from unimolecular decay of anti-MVK-oxide and subsequent reaction with O2 are formaldehyde (88 +- 5%), ketene (9 +- 1%) and glyoxal (3 +- 1%).	Oxygen	138-140	mevalonate kinase	Homo sapiens	99-102
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	66-72	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	66-72	deleted in esophageal cancer 1	Homo sapiens	244-249
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	258-264	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	258-264	deleted in esophageal cancer 1	Homo sapiens	244-249
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	463-465	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Oxygen	463-465	deleted in esophageal cancer 1	Homo sapiens	244-249
32370790-11	2020	Furthermore, overexpressing gma-miR398c in soybean decreased GmCSD1a/b, GmCSD2a/b/c and GmCCS expression, which weakened the ability to scavenge O2.-, resulting in increased relative electrolyte leakage and stomatal opening compared with knockout miR398c and wild-type soybean under drought conditions.	Oxygen	145-147	MIR398C	Glycine max	28-39
32370790-11	2020	Furthermore, overexpressing gma-miR398c in soybean decreased GmCSD1a/b, GmCSD2a/b/c and GmCCS expression, which weakened the ability to scavenge O2.-, resulting in increased relative electrolyte leakage and stomatal opening compared with knockout miR398c and wild-type soybean under drought conditions.	Oxygen	145-147	MIR398C	Glycine max	32-39
33338600-5	2021	In a hyperoxia-based animal model of BPD, oxygen exposure deregulated MPST expression during post-natal lung development, where MPST was localized to the smooth muscle layer of the pulmonary vessels in developing lungs.	Oxygen	42-48	mercaptopyruvate sulfurtransferase	Homo sapiens	128-132
31733286-8	2020	Mechanistically, absence of PAR2 in MDSCs directly enhanced their immunosuppressive activity by promoting STAT3-mediated reactive oxygen species production.	Oxygen	130-136	F2R like trypsin receptor 1	Homo sapiens	28-32
33552276-2	2021	MT1-MMP subcellular localisation varies with oxygen tension, and, therefore, the aim of the present study was to assess protein interactions between MT1-MMP and the hypoxia inducible factors (HIF-1alpha and HIF-2alpha).	Oxygen	45-51	matrix metallopeptidase 14	Homo sapiens	0-7
31870843-8	2020	Furthermore, we found that agonism of GPR120 could suppress oxidative stress and inflammation by inhibiting the production of reactive oxygen species and the expression of proinflammatory cytokines.	Oxygen	135-141	free fatty acid receptor 4	Homo sapiens	38-44
32149414-10	2020	First, proper level of SOD2 helped CRC cells maintain mitochondrial function by disposal of superoxide (O2 .- ).	Oxygen	104-106	superoxide dismutase 2	Homo sapiens	23-27
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	Oxygen	111-117	apelin receptor	Homo sapiens	24-27
32312382-3	2020	By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by laser-wounding.	Oxygen	242-248	kinase insert domain protein receptor	Mus musculus	66-81
32312382-3	2020	By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by laser-wounding.	Oxygen	242-248	kinase insert domain protein receptor	Mus musculus	83-89
32312382-3	2020	By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by laser-wounding.	Oxygen	242-248	kinase insert domain protein receptor	Mus musculus	169-175
31821872-0	2020	KLF2 protects BV2 microglial cells against oxygen and glucose deprivation injury by modulating BDNF/TrkB pathway.	Oxygen	43-49	Kruppel-like factor 2 (lung)	Mus musculus	0-4
31821872-3	2020	Our study aimed to investigate the effects and underlying mechanism of KLF2 in BV2 microglial cells exposed to oxygen and glucose deprivation (OGD).	Oxygen	111-117	Kruppel-like factor 2 (lung)	Mus musculus	71-75
32051831-3	2020	Using a high-fat diet-induced IR mouse model, we here show that NADPH oxidase 4 (Nox4) upregulation mediates the production of reactive oxygen species (ROS) that causes metabolic syndrome featuring IR.	Oxygen	136-142	NADPH oxidase 4	Mus musculus	64-79
32051831-3	2020	Using a high-fat diet-induced IR mouse model, we here show that NADPH oxidase 4 (Nox4) upregulation mediates the production of reactive oxygen species (ROS) that causes metabolic syndrome featuring IR.	Oxygen	136-142	NADPH oxidase 4	Mus musculus	81-85
31963754-6	2020	MIF secretion was dependent on an increase in reactive oxygen species (ROS) induced by the inhibition of autophagy.	Oxygen	55-61	macrophage migration inhibitory factor	Homo sapiens	0-3
31948482-13	2020	CONCLUSIONS: 6beta-OHT is required for the action of Ang II to increase vascular reactivity and cause endothelial dysfunction, hypertrophy, and increase in oxygen radical production.	Oxygen	156-162	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	53-56
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	Oxygen	111-117	glycogen synthase kinase 3 alpha	Homo sapiens	51-59
32152200-7	2020	Here, we test this hypothesis in a neuronal model of ischemia-reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress.	Oxygen	160-166	prohibitin	Mus musculus	102-105
33479347-2	2021	TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or pungent substances, and it participates in pain signalling, taste, inflammation and various steps of the tumorigenic process.	Oxygen	97-103	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
32296963-2	2020	The electrocatalytic performance evaluations show that the as-prepared electrocatalyst exhibits an overpotential of 342 mV at current density of 10 mA cm-2 and the Tafel slope of 74 mV dec-1 for oxygen evolution reaction (OER), which is superior to the most advanced ruthenium oxide electrocatalyst.	Oxygen	195-201	deleted in esophageal cancer 1	Homo sapiens	185-190
31829341-0	2020	Conversion of NOx1- (x = 2, 3) to NO using an oxygen-deficient polyoxovanadate-alkoxide cluster.	Oxygen	46-52	NADPH oxidase 1	Homo sapiens	14-18
31829341-2	2020	Reduction of NO21- and NO31- results in near-quantitative oxygen atom transfer to the coordinatively unsaturated VIII ion, and selective formation of NO.	Oxygen	58-64	cytochrome c oxidase subunit 8A	Homo sapiens	113-117
33441918-7	2021	p300 knockdown decreased myotube formation efficiency, MYH2 expression, and basal oxygen consumption rate.	Oxygen	82-88	E1A binding protein p300	Homo sapiens	0-4
31923239-3	2020	We measured: (i) the external limiting membrane-retinal pigment epithelium region thickness (ELM-RPE; OCT), which decreases substantially with upregulation of a pH-sensitive water removal co-transporter on the apical portion of the RPE, and (ii) the outer retina R1 (= 1/(spin lattice relaxation time (T1), an MRI parameter proportional to oxygen / free radical content.	Oxygen	340-346	plexin A2	Mus musculus	102-105
32271805-3	2020	Based on these previous results, we hypothesized that SGSM3 could also play a role in bone marrow-derived rat mesenchymal stem cells (MSCs), which differentiate into cardiomyocytes and/or cells with comparable phenotypes under low oxygen conditions.	Oxygen	231-237	small G protein signaling modulator 3	Rattus norvegicus	54-59
32271805-5	2020	We identified that SGSM3 interacts with Cx43 in MSCs under different oxygen conditions and that Sgsm3 knockdown inhibits apoptosis and cardiomyocyte differentiation under hypoxic stress.	Oxygen	69-75	small G protein signaling modulator 3	Rattus norvegicus	19-24
33532034-0	2021	Corrigendum to "Inhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species".	Oxygen	146-152	uncoupling protein 2	Homo sapiens	30-50
31954719-0	2020	OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels.	Oxygen	24-30	pyruvate kinase, muscle	Mus musculus	132-150
31924757-1	2020	mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood.	Oxygen	75-81	CREB regulated transcription coactivator 1	Mus musculus	0-6
31670037-7	2020	The peroxy radical, which is generated from the incorporation of H-abstraction product radicals (P7H, P9H, and P10H) with O2, prefers to produce HO2  into the surrounding through direct concerted elimination rather than the indirect mechanism.	Oxygen	4-18	heme oxygenase 2	Homo sapiens	145-148
31670037-7	2020	The peroxy radical, which is generated from the incorporation of H-abstraction product radicals (P7H, P9H, and P10H) with O2, prefers to produce HO2  into the surrounding through direct concerted elimination rather than the indirect mechanism.	Oxygen	122-124	heme oxygenase 2	Homo sapiens	145-148
31689123-0	2020	Long noncoding RNA MALAT1 participates in the pathological angiogenesis of diabetic retinopathy in an oxygen-induced retinopathy mouse model by sponging miR-203a-3p.	Oxygen	102-108	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	19-25
33488404-9	2020	The hemodynamic results showed that oxygen enrichment decreased right ventricular systolic pressure (RVSP) and mean pulmonary artery pressure (mPAP) in HAH-exposed rats.	Oxygen	36-42	phospholipid phosphatase 1	Mus musculus	143-147
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	Oxygen	136-142	NADPH oxidase 4	Homo sapiens	74-78
31755176-3	2020	Within 30 min after UVB irradiation, TRPC7 mediated UVB-induced Ca2+ influx and the subsequent production of reactive oxygen species in skin cells.	Oxygen	118-124	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	37-42
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	Oxygen	136-142	lysine acetyltransferase 2B	Homo sapiens	171-174
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	interleukin 18	Mus musculus	276-281
31898278-2	2020	Here, we show that SCA2 patient cells exhibit higher levels of caspase-8- and caspase-9-mediated apoptotic activation than control cells, cellular phenotypes that we find to be exacerbated by reactive oxygen species (ROS) and inhibition of autophagy.	Oxygen	201-207	caspase 8	Homo sapiens	63-72
31868937-0	2020	Inhibition of microRNA-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signaling.	Oxygen	42-48	sestrin 2	Homo sapiens	165-173
33040597-7	2020	CTRP9 overexpression significantly attenuated HG-induced oxidative stress, as proved by decreased levels of reactive oxygen species and malondialdehyde, and increased superoxide dismutase activity.	Oxygen	117-123	C1q and TNF related 9	Homo sapiens	0-5
31676569-6	2020	Additionally, CTRP13 treatment reduced reactive oxygen species overproduction and improved nitric oxide (NO) production and eNOS coupling in the aortae of diabetic mice and in HG-treated HUVECs.	Oxygen	48-54	C1q-like 3	Mus musculus	14-20
32337954-8	2020	The levels of cytokines and reactive oxygen species were reduced in the miR-668 inhibitor treatment group compared to the stroke group.	Oxygen	37-43	microRNA 668	Rattus norvegicus	72-79
31821410-3	2021	NADPH oxidase-4 (Nox4) is a reactive oxygen species (ROS)-generating enzyme that can limit detrimental cardiac remodelling in response to pressure overload.	Oxygen	37-43	NADPH oxidase 4	Mus musculus	0-15
31782248-6	2020	In vitro, the silencing of circNr1h4 or overexpression of miR-155-5p significantly decreased Far1 levels and increased reactive oxygen species.	Oxygen	128-134	microRNA 155	Mus musculus	58-65
31809712-0	2020	Overexpression of cortistatin alleviates oxygen/glucose-deprivation-induced ER stress and prompts neural stem cell proliferation via SSTR2.	Oxygen	41-47	cortistatin	Rattus norvegicus	18-29
32052890-0	2020	Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury.	Oxygen	99-105	adenosine A2a receptor	Mus musculus	0-22
32052890-0	2020	Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury.	Oxygen	99-105	adenosine A2a receptor	Mus musculus	24-28
32052890-4	2020	In primary murine chondrocytes from A2AR-/- null mice, which develop spontaneous OA by 16 weeks, there is mitochondrial swelling, dysfunction, and reduced mitochondrial content with increased reactive oxygen species (ROS) burden and diminished mitophagy, as compared to chondrocytes from WT animals.	Oxygen	201-207	adenosine A2a receptor	Mus musculus	36-40
31821410-3	2021	NADPH oxidase-4 (Nox4) is a reactive oxygen species (ROS)-generating enzyme that can limit detrimental cardiac remodelling in response to pressure overload.	Oxygen	37-43	NADPH oxidase 4	Mus musculus	17-21
31663146-11	2020	It has been proved that wheat bran has a good blood pressure lowering and antioxidation and other biological activities, and the <1 kDa fraction showing high oxygen radical absorbance capacity level also has better in vitro ACE inhibition and renin-inhibitory activity.	Oxygen	158-164	renin	Rattus norvegicus	243-248
31821410-15	2021	Our study identifies the reactive oxygen species generating enzyme NADPH oxidase-4 (Nox4) as an important regulator of volume overload-induced cardiac remodelling by promoting eccentric LV hypertrophy, an adaptive response to the increased volume.	Oxygen	34-40	NADPH oxidase 4	Mus musculus	67-82
32364989-6	2020	Lipase (LPL), glutathione peroxidase 3 (GPX3), cathelicidin-2 (CATHL2), ceruloplasmin (CP), and hemoglobin subunit alpha 1 (HBA1) cooperatively played roles in the thermal fitness of dairy buffalo by decreasing heat production and increasing blood oxygen delivery.	Oxygen	248-254	hemoglobin subunit alpha 1	Homo sapiens	96-122
31821410-15	2021	Our study identifies the reactive oxygen species generating enzyme NADPH oxidase-4 (Nox4) as an important regulator of volume overload-induced cardiac remodelling by promoting eccentric LV hypertrophy, an adaptive response to the increased volume.	Oxygen	34-40	NADPH oxidase 4	Mus musculus	84-88
32364989-7	2020	Also, dairy buffaloes may adapt to CHS and hypoxia with high levels of RBCs, HBA1 and CP to increase blood oxygen delivery capacity.	Oxygen	107-113	hemoglobin subunit alpha 1	Homo sapiens	77-81
33166649-2	2021	Neuroglobin is an oxygen-binding globin found in neurons within the central nervous system as well as in peripheral neurons, that produces a protective effect against hypoxic/ischemic damaging insults by promoting oxygen availability within the mitochondria.	Oxygen	18-24	neuroglobin	Mus musculus	0-11
32036801-10	2020	Reactive oxygen species (ROS) levels were significantly increased in the CX43 knockdown group compared to those in control embryos.	Oxygen	9-15	gap junction protein alpha 1	Homo sapiens	73-77
31918925-11	2020	In agreement with this role, the H6PD enzymatic response to both STZ-DM and MTF matched the activation of the NADPH-dependent antioxidant responses to the increased generation of reactive oxygen species caused by chronic hyperglycemia.	Oxygen	188-194	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	110-115
33166649-2	2021	Neuroglobin is an oxygen-binding globin found in neurons within the central nervous system as well as in peripheral neurons, that produces a protective effect against hypoxic/ischemic damaging insults by promoting oxygen availability within the mitochondria.	Oxygen	214-220	neuroglobin	Mus musculus	0-11
31819254-5	2020	This triggers Lyn/Syk-dependent calcium entry and the production of reactive oxygen species, leading to activation of caspase-8.	Oxygen	77-83	caspase 8	Homo sapiens	118-127
33213633-3	2021	VIII orebody represents the early crystallizing phase characterized by high temperature and oxygen fugacity.	Oxygen	92-98	cytochrome c oxidase subunit 8A	Homo sapiens	0-4
32694681-5	2020	SRR-mediated dehydration of serine contributes to the pyruvate pool in colon-cancer cells, enhances proliferation, maintains mitochondrial mass and increases basal reactive oxygen species production, which has anti-apoptotic effects.	Oxygen	173-179	serine racemase	Homo sapiens	0-3
31670612-6	2020	TRPA1 has been reported to be activated by cold, heat, and mechanical stimuli, and its function is modulated by multiple factors, including Ca2+, trace metals, pH, and reactive oxygen, nitrogen, and carbonyl species.	Oxygen	177-183	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
33046676-9	2020	These changes in H2O2 and O2 - in yeasts were altered by reductants or inhibitors of scavenging enzyme by means of regulating the expression of ATG11 and ATG32 genes.	Oxygen	19-21	autophagy protein ATG11	Saccharomyces cerevisiae S288C	144-149
32063036-10	2020	To conclude, reactive oxygen species in semen is considered to have an adverse effect on both the early and late stages of embryo development in intracytoplasmic sperm injection.Abbreviations: GnRH, gonadotropin-releasing hormone; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; LPO, lipid peroxidation; NADPH, nicotinamide adenine dinucleotide phosphate; RLU, relative light units; ROC, receiver operating characteristic; ROS, reactive oxygen species.	Oxygen	22-28	gonadotropin releasing hormone 1	Homo sapiens	199-229
31765888-6	2020	In addition, Alkbh8def MEFs undergo a metabolic shift that is highlighted by a striking increase in the level of uncoupling protein 2 (UCP2) which enhances oxygen consumption and promotes a reliance on glycolytic metabolism.	Oxygen	156-162	alkB homolog 8, tRNA methyltransferase	Mus musculus	13-19
33046676-10	2020	Inhibitors of the mitochondrial electron transport chain (mtETC) also increased production of H2O2 and O2 - by enhancing expression of the ATG11 and ATG32 genes.	Oxygen	103-107	autophagy protein ATG11	Saccharomyces cerevisiae S288C	139-144
31774621-4	2020	This oxygen-doped complex is used as an effective CO2 catalyst, which exhibits a maximum CO Faradaic efficiency of 91% at -0.8 V (vs reversible hydrogen electrode, RHE) and long-term stability throughout 30 h of electrocatalysis.	Oxygen	5-11	factor interacting with PAPOLA and CPSF1	Homo sapiens	164-167
32176957-8	2020	Hyperbaric oxygen improves mitochondrial function, inhibits lipid peroxidation transiently, impairs leukocyte adhesion to injured microvasculature, and reduces brain inflammation caused by the CO-induced adduct formation of myelin basic protein.	Oxygen	11-17	myelin basic protein	Homo sapiens	224-244
32200095-4	2020	Bearing the same bda2- and amphiphilic axial ligands, monomer 1 and green dimer 2 can be reversibly converted by ascorbic acid and oxygen, respectively, in aqueous solution.	Oxygen	131-137	bone morphogenetic protein 2	Homo sapiens	17-21
32108463-3	2020	They exhibit an outstanding catalytic activity for oxygen evolution reaction (OER) with a low overpotential of 229 mV at a current density of 10 mA cm-2, a high turnover frequency value of 0.35 s-1 at an overpotential of 300 mV, and an ultralow Tafel slope of 27.6 mV dec-1, which is much better than that of FeP/Fe3O4, FeP/CNTs, Fe3O4/CNTs, and the commercial RuO2 electrocatalyst.	Oxygen	51-57	deleted in esophageal cancer 1	Homo sapiens	268-273
33299012-6	2020	Comprehensive screening of BEX2 binding proteins identified E3 ubiquitin ligase complex proteins, FEM1B and CUL2, and a mitochondrial protein TUFM, and further demonstrated that knockdown of BEX2 or TUFM increased mitochondria-related oxygen consumption and decreased tumorigenicity in cholangiocarcinoma cells.	Oxygen	235-241	brain expressed X-linked 2	Homo sapiens	27-31
32090552-5	2020	Thus, the obtained catalyst established by electrocatalytic activity in the course of the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) in 1 M KOH solution requires overpotentials (eta) of 290 and 150 mV to achieve a current density of 50 and 10 mA cm-2 for both OER and HER.	Oxygen	90-96	endothelin receptor type A	Homo sapiens	209-212
31867906-0	2019	[Correlation between blood oxygen level dependent fMRI signal and GABA content in anterior cingulate cortex after acupuncture of Hegu (LI4)].	Oxygen	27-33	lipase family member N	Homo sapiens	135-138
33299012-6	2020	Comprehensive screening of BEX2 binding proteins identified E3 ubiquitin ligase complex proteins, FEM1B and CUL2, and a mitochondrial protein TUFM, and further demonstrated that knockdown of BEX2 or TUFM increased mitochondria-related oxygen consumption and decreased tumorigenicity in cholangiocarcinoma cells.	Oxygen	235-241	brain expressed X-linked 2	Homo sapiens	191-195
33376865-9	2020	The limiting oxygen values of EP/MO-PEI@NH2-MIL-101(Al) and EP/DR80-PEI@NH2-MIL-101(Al) increased to 26.5 and 26.7%, respectively.	Oxygen	13-19	epiregulin	Homo sapiens	30-32
31612590-2	2019	Porous Cu x Co y S SPs produced the highest reactive oxygen species (ROS) yield (1.39) when illuminated by near-infrared (NIR) light.	Oxygen	53-59	cut like homeobox 1	Homo sapiens	7-11
32024700-5	2020	In this study, we show that in addition to IL-1beta, PSTPIP2 also negatively regulates pathways governing reactive oxygen species generation by neutrophil NOX2 NADPH oxidase.	Oxygen	115-121	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	53-60
33376865-9	2020	The limiting oxygen values of EP/MO-PEI@NH2-MIL-101(Al) and EP/DR80-PEI@NH2-MIL-101(Al) increased to 26.5 and 26.7%, respectively.	Oxygen	13-19	epiregulin	Homo sapiens	60-62
32045384-7	2020	A unique MSC transcriptome was observed in MDS-MSCs compared to HD-MSCs, including increased expression of the reactive oxygen species (ROS) regulator, ENC1.	Oxygen	120-126	ectodermal-neural cortex 1	Homo sapiens	152-156
32043019-1	2020	This study sought to investigate whether reactive oxygen species (ROS)-generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to calcific aortic valve disease (CAVD) or whether celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target for CAVD.	Oxygen	50-56	cytochrome b-245 heavy chain	Oryctolagus cuniculus	90-143
32043019-1	2020	This study sought to investigate whether reactive oxygen species (ROS)-generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to calcific aortic valve disease (CAVD) or whether celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target for CAVD.	Oxygen	50-56	cytochrome b-245 heavy chain	Oryctolagus cuniculus	145-149
33180482-1	2020	We describe here nitric oxide dioxygenation (NOD) by the dioxygen manganese porphyrin adducts Mn(Por)(eta2-O2) (Por2- = the meso-tetra-phenyl or meso-tetra-p-tolylporphyrinato dianions, TPP2- and TTP2-).	Oxygen	30-38	DNA polymerase iota	Homo sapiens	102-106
31855167-2	2019	Continuous positive airway pressure (CPAP) and adaptive servoventilation (ASV) as well as nocturnal oxygen (O2) are proposed treatment modalities of CSA/CSR.	Oxygen	100-106	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	149-152
32293153-8	2020	It reveals that NIR-LED inhibits the production of reactive oxygen species by regulating the Nox4-NF-kappaB pathway.	Oxygen	60-66	NADPH oxidase 4	Homo sapiens	93-97
33180482-2	2020	The Mn(Por)(eta2-O2) was assembled by adding O2 to sublimed layers of MnII(Por).	Oxygen	17-19	DNA polymerase iota	Homo sapiens	12-16
32659785-10	2020	Because the prolyl hydroxylases that regulate HIF stability are oxygen and iron-dependent enzymes, our findings suggest a novel mechanism by which hypoxia and iron deficiency may modulate NCOA4 expression to impact iron homeostasis.	Oxygen	64-70	nuclear receptor coactivator 4	Mus musculus	188-193
31935112-9	2020	Furthermore, glucose metabolism through PPP was also enhanced by TXNIP depletion, as TXNIP siRNA treatment promotes glucose-6-phosphate dehydrogenase (G6PDH) activity and NADPH content, and helped maintain a high level of glutathione and a low level of reactive oxygen species within the oocytes.	Oxygen	262-268	thioredoxin interacting protein	Bos taurus	65-70
31935112-9	2020	Furthermore, glucose metabolism through PPP was also enhanced by TXNIP depletion, as TXNIP siRNA treatment promotes glucose-6-phosphate dehydrogenase (G6PDH) activity and NADPH content, and helped maintain a high level of glutathione and a low level of reactive oxygen species within the oocytes.	Oxygen	262-268	thioredoxin interacting protein	Bos taurus	85-90
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	Sp7 transcription factor	Homo sapiens	83-86
31768526-7	2019	Mechanistically, ox-LDL treatment in HUVECs might activate the NF-kappaB pathway, which transcriptionally activates miR-505, and then the exosome-encapsulated high miR-505 expression targeted and inhibited SIRT3 in neutrophils, thereby inducing reactive oxygen species (ROS) level increase and NET release by neutrophils.	Oxygen	254-260	microRNA 505	Homo sapiens	164-171
32208775-5	2020	Cellular redox state influences the levels of oxygen dependent ten eleven translocase (TET) demethylase, hypoxia inducible factor-1alpha (HIF-1alpha), and metabolic reprogramming which in turn control the epigenetic modification, transcription, translation and post translational stability of FoxP3, the master regulator of regulatory T cell induction and maintenance.	Oxygen	46-52	forkhead box P3	Homo sapiens	293-298
31921851-6	2019	In contrast, oxygen-glucose deprivation (OGD)-induced downregulation of NFAT5 expression was reversed by treating with hypertonic saline, which ameliorated aberrant NKCC1 expression.	Oxygen	13-27	nuclear factor of activated T cells 5	Homo sapiens	72-77
33423492-4	2019	Monolayer cultures under low oxygen conditions exhibited increased expression of hypoxia-related genes such as VEGF, CAIX, and GLUT1.	Oxygen	29-35	carbonic anhydrase 9	Homo sapiens	117-121
31805953-14	2019	Mechanistically, microglia with elevated G6PD activity/expression produced excessive NADPH and provided abundant substrate to over-activated NADPH oxidase (NOX2) leading to production of excessive reactive oxygen species (ROS).	Oxygen	206-212	cytochrome b-245, beta polypeptide	Mus musculus	156-160
31708362-5	2020	When compared with PE-C, patients with PE-E presented a higher prevalence of chronic cardiopulmonary disease (17.37% vs 8.02%, p = 0.003), a lower prevalence of pulse rate >110 (13.13% vs 25.93%; p<0.001), of arterial oxygen saturation <90% (16.16% vs. 25.93%; p = 0.007) and of hospitalized patients (52.93% vs 98.15%; p < 0.001).	Oxygen	218-224	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	39-43
31909875-7	2020	Finally, reactive oxygen species (ROS) content was decreased in NNMT-expressing cells (0.3 +- 0.08 vs 0.12 +- 0.03; P = .039), as was the concentration of 8-isoprostane F2alpha (200 +- 11.5 vs 45 +- 2.6 pg/mg protein; P = .0012).	Oxygen	18-24	nicotinamide N-methyltransferase	Homo sapiens	64-68
32208775-7	2020	Incidentally, the changes in blood oxygen levels in pregnant women and developing foetus are accompanied by increase in tolerance due to increased frequency of CD4 + CD25 + FoxP3+ regulatory T cells.	Oxygen	35-41	interleukin 2 receptor subunit alpha	Homo sapiens	166-170
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine kinase 1	Mus musculus	136-141
31949986-0	2019	Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons.	Oxygen	67-73	neuregulin 1	Homo sapiens	0-12
31949986-0	2019	Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons.	Oxygen	67-73	erb-b2 receptor tyrosine kinase 4	Homo sapiens	13-18
32208775-7	2020	Incidentally, the changes in blood oxygen levels in pregnant women and developing foetus are accompanied by increase in tolerance due to increased frequency of CD4 + CD25 + FoxP3+ regulatory T cells.	Oxygen	35-41	forkhead box P3	Homo sapiens	173-178
33216086-9	2020	The levels of O2 -, H2O2, and  OH were enhanced, but the activities of SOD, GSH-PX, and POD were decreased by the interference of Wnt10b RNA.	Oxygen	14-18	wingless-type MMTV integration site family, member 10b	Danio rerio	130-136
31712880-0	2019	Hemoglobin Kirklareli [Alpha2 59(E7) His>Leu; HBA2:c.176A>T] in a Brazilian child with severe dyspnea and low O2 saturation.	Oxygen	110-112	hemoglobin subunit alpha 2	Homo sapiens	46-50
31870893-0	2020	MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4.	Oxygen	22-28	programmed cell death 4	Homo sapiens	124-129
32860611-7	2020	LncRNA SNHG3 was highly expressed in the mouse model of transient middle cerebral artery occlusion and cell model of Oxygen and Glucose Deprivation/Reperfusion, while miR-485 was lowly expressed.	Oxygen	117-123	small nucleolar RNA host gene 3	Mus musculus	7-12
31945389-11	2020	In addition, increase in mitochondrial ERbeta localization may also trigger mitochondrial metabolism, suppress biosynthetic process of gluconeogenesis, as indicated by the observed reduction in the phosphoenolopyruvate carboxykinase protein level, and eventually lead to increase in reactive oxygen species (ROS) generation, known to be implicated in aluminum induced neurodegeneration.	Oxygen	292-298	estrogen receptor 2	Homo sapiens	39-45
31962380-11	2020	Moreover, SIX2 deficiency eliminated the promotion effects of miR-335-5p inhibitor on oxygen consumption, colony formation, and cell mobility in BC cells.	Oxygen	86-92	SIX homeobox 2	Homo sapiens	10-14
31962380-11	2020	Moreover, SIX2 deficiency eliminated the promotion effects of miR-335-5p inhibitor on oxygen consumption, colony formation, and cell mobility in BC cells.	Oxygen	86-92	microRNA 335	Homo sapiens	62-69
31648561-7	2019	TWIST2 overexpression decreased intracellular reactive oxygen species level, increased mitochondrial DNA and biogenesis, and enhanced ATP production and antioxidation ability.	Oxygen	55-61	twist basic helix-loop-helix transcription factor 2	Mus musculus	0-6
33230296-5	2020	UCP2-silenced KRASmut cell lines display decreased glutaminolysis, lower NADPH/NADP+ and glutathione/glutathione disulfide ratios and higher reactive oxygen species levels compared to wild-type counterparts.	Oxygen	150-156	uncoupling protein 2	Homo sapiens	0-4
30661173-2	2019	We, therefore, investigated the role of NADPH oxidase derived O2.--mediated modulation of MMP2-sphingomyeline-ceramide-S1P signalling axis in ET-1 induced increase in proliferation of PASMCs.	Oxygen	62-64	matrix metallopeptidase 2	Bos taurus	90-94
31736209-0	2020	Hyperbaric Oxygen Therapy Accelerates Wound Healing in Diabetic Mice by Decreasing Active Matrix Metalloproteinase-9.	Oxygen	11-17	matrix metallopeptidase 9	Mus musculus	90-116
33213523-4	2020	The potential molecular mechanisms of TUG1 in regulating hippocampal neuronal apoptosis were explored in oxygen and glucose deprivation-induced (OGD-induced) hippocampal cell line HT22.	Oxygen	105-111	taurine up-regulated 1	Homo sapiens	38-42
32009135-2	2020	Then, a first new porous d-p heterometallic MOF (HMOF), namely {[PbZn(L)2] DMA H2O}n (2), was yielded via Zn(ii) ions and MOF 1 as the precursor because of the different coordination affinity of oxygen and nitrogen atoms with various metal ions.	Oxygen	195-201	lysine acetyltransferase 8	Homo sapiens	29-47
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	haptoglobin-related protein	Homo sapiens	13-16
33057532-7	2020	We further detail investigations surrounding the ability of these oxygen-deficient sites to mediate reductive transformations such as O2 and NOx1- (x = 2, 3) activation.	Oxygen	66-72	NADPH oxidase 1	Homo sapiens	141-145
31721424-4	2019	The NiCoFe-PS nanorod/NF can reach 10 mA cm-2 at a small overpotential of 195 mV with a Tafel slope of 40.3 mV dec-1 for the oxygen evolution reaction and 97.8 mV with 51.8 mV dec-1 for the hydrogen evolution reaction.	Oxygen	125-131	deleted in esophageal cancer 1	Homo sapiens	111-116
32258386-6	2020	Mechanistically, by targeting SIX1, miR-489-3p dampens glycolysis, with decreased glucose uptake, lactate production, ATP generation, and extracellular acidification rate (ECAR), as well as an increased oxygen consumption rate (OCR).	Oxygen	203-209	SIX homeobox 1	Homo sapiens	30-34
32009135-2	2020	Then, a first new porous d-p heterometallic MOF (HMOF), namely {[PbZn(L)2] DMA H2O}n (2), was yielded via Zn(ii) ions and MOF 1 as the precursor because of the different coordination affinity of oxygen and nitrogen atoms with various metal ions.	Oxygen	195-201	lysine acetyltransferase 8	Homo sapiens	49-53
32009135-3	2020	MOF 1 is a condensed packing motif, whereas HMOF 2 is a porous three-dimensional (3D) framework with unsaturated Pb(ii) and Zn(ii) active sites, uncoordinated carboxylate oxygen atoms and two kinds of porous channels due to the introduction of Zn(ii) ions into the framework of MOF 1, which thus endowed HMOF 2 with excellent sorption and selectivity for CO2 over CH4.	Oxygen	159-177	lysine acetyltransferase 8	Homo sapiens	44-48
32085461-1	2020	The expression of HIGD2A is dependent on oxygen levels, glucose concentration, and cell cycle progression.	Oxygen	41-47	HIG1 domain family, member 2A	Mus musculus	18-24
32066777-0	2020	VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration.	Oxygen	70-76	fibroblast growth factor 2	Rattus norvegicus	9-13
31993622-3	2020	Herein, quinone and ester-type oxygen-modified carbon has been successfully obtained by chemical activation with alkali, which is beneficial to the absorption of PF6- together with lithium ions, which would largely improve the electrode kinetics.	Oxygen	31-37	sperm associated antigen 17	Homo sapiens	162-165
31591207-4	2019	Acetylated SOD2 promotes hypoxic signaling via increased mitochondrial reactive oxygen species (mtROS).	Oxygen	80-86	superoxide dismutase 2	Homo sapiens	11-15
33173134-4	2020	The 13 outlier windows detected by at least two approaches, harboured genes (e.g. GH1, ACE, ASIC3, HSPH1, MVD, BCL2, HIGD2A, CBFA2T3) that may be involved in physiological adaptations required to cope with environmental stressors that are typical of the North African area such as infectious diseases, extended drought periods, scarce food supply, oxygen scarcity in the mountainous areas and high-intensity solar radiation.	Oxygen	348-354	angiotensin I converting enzyme	Bos taurus	87-90
31827666-5	2019	GDNF (1 ng/ml) was added to the culture medium 20 min before oxygen deprivation.	Oxygen	61-67	glial cell line derived neurotrophic factor	Mus musculus	0-4
31827673-2	2019	NADPH oxidase 4 (Nox4) regulates cellular processes such as proliferation, differentiation, and survival by producing reactive oxygen species (ROS).	Oxygen	127-133	NADPH oxidase 4	Mus musculus	0-15
31827673-2	2019	NADPH oxidase 4 (Nox4) regulates cellular processes such as proliferation, differentiation, and survival by producing reactive oxygen species (ROS).	Oxygen	127-133	NADPH oxidase 4	Mus musculus	17-21
32104537-7	2020	H2 activated extracellular signal-regulated kinase and c-Jun N-terminal protein kinase and dephosphorylated p38 mitogen-activated protein kinase (MAPK) in oxygen-glucose deprivation/reperfusion (OGD/R) nerve growth factor-differentiated PC12 cells.	Oxygen	155-161	mitogen activated protein kinase 14	Rattus norvegicus	108-144
33173134-4	2020	The 13 outlier windows detected by at least two approaches, harboured genes (e.g. GH1, ACE, ASIC3, HSPH1, MVD, BCL2, HIGD2A, CBFA2T3) that may be involved in physiological adaptations required to cope with environmental stressors that are typical of the North African area such as infectious diseases, extended drought periods, scarce food supply, oxygen scarcity in the mountainous areas and high-intensity solar radiation.	Oxygen	348-354	heat shock protein family H (Hsp110) member 1	Bos taurus	99-104
33103907-9	2020	Conversely, because the N-terminus of AE1 stabilizes deoxyhemoglobin and finely tunes oxygen off-loading and metabolic rewiring toward the hexose monophosphate shunt, RBCs from COVID-19 patients may be less capable of responding to environmental variations in hemoglobin oxygen saturation/oxidant stress when traveling from the lungs to peripheral capillaries and vice versa.	Oxygen	86-92	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	38-41
31784084-12	2020	In vitro, the neuron-glial mixed culture by fluorescent staining showed that oxygen glucose deprivation (OGD) treatment led to significant cell death, while being attenuated by Vsig4 over-expression in primary microglial cells.	Oxygen	77-83	V-set and immunoglobulin domain containing 4	Mus musculus	177-182
31604821-8	2019	In both tumor and healthy cells, V-ATPase inhibition induced a distinct metabolic regulatory cascade downstream of AMPK, affecting ATP and NADPH levels, glucose uptake, and reactive oxygen species (ROS) production.	Oxygen	182-188	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
33103907-9	2020	Conversely, because the N-terminus of AE1 stabilizes deoxyhemoglobin and finely tunes oxygen off-loading and metabolic rewiring toward the hexose monophosphate shunt, RBCs from COVID-19 patients may be less capable of responding to environmental variations in hemoglobin oxygen saturation/oxidant stress when traveling from the lungs to peripheral capillaries and vice versa.	Oxygen	271-277	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	38-41
32047214-0	2020	Non-secretory renin reduces oxidative stress and increases cardiomyoblast survival during glucose and oxygen deprivation.	Oxygen	102-108	renin	Rattus norvegicus	14-19
33147875-6	2020	These compounds, designated MMA, bind to the alpha-globin and/or beta-globin to increase Hb affinity for oxygen and concomitantly inhibit erythrocyte sickling with significantly enhanced and sustained pharmacologic activities in vitro.	Oxygen	105-111	hemoglobin subunit alpha 2	Homo sapiens	45-57
32034213-6	2020	Moreover, SME inhibited LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) in RAW264.7 cells, and attenuated the generation of ERK1 induced-reactive oxygen species (ROS), resulting in decreased expression of NF-kappaB.	Oxygen	173-179	mitogen-activated protein kinase 3	Mus musculus	151-155
31441970-4	2019	A new index (eta) was defined to quantify the regularity around the metal based on differences in the oxygen-metal-oxygen angles.	Oxygen	102-108	endothelin receptor type A	Homo sapiens	13-16
31441970-4	2019	A new index (eta) was defined to quantify the regularity around the metal based on differences in the oxygen-metal-oxygen angles.	Oxygen	115-121	endothelin receptor type A	Homo sapiens	13-16
31927141-9	2020	Conversely, if excessive fuel flux surpasses the capacity of the respiratory chain, threatening the release of damaging reactive oxygen species (ROS), the polarity of the cytochrome c redox system is reversed, resulting in the chemical reduction of the PKCdelta CRD, restoration of the RING-finger, refolding of PKCdelta into the inactive, globular form, and curtailment of PDHC output, thereby constraining the respiratory capacity within safe margins.	Oxygen	129-135	protein kinase C delta	Homo sapiens	253-261
31956425-1	2020	Carbon-SnO x composites are obtained by impregnating acetylacetone-treated, delignified wood fibers with tin precursor and successively carbonizing at 1000  C in 95% argon and 5% oxygen.	Oxygen	179-185	strawberry notch homolog 1	Homo sapiens	7-10
32033016-2	2020	The results of a molecular docking study showed that the oxygen atom in the five-membered ring of octenyl succinic anhydride (OSA) formed a strong hydrogen bond interaction (1.89 A) with the hydrogen atom in the hydroxyl group of C-6.	Oxygen	57-63	complement C6	Homo sapiens	230-233
32440726-6	2020	Overexpression of mutant ATP1A3 in vitro led to a reduced oxygen consumption rate (OCR), reflecting the limited mitochondrial reserve capacity.	Oxygen	58-64	ATPase, Na+/K+ transporting, alpha 3 polypeptide	Mus musculus	25-31
31918224-0	2020	Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-alpha/BAFF signaling pathway.	Oxygen	9-15	TNF superfamily member 13b	Homo sapiens	154-158
31106420-0	2019	Bone marrow mesenchymal stem cells modified by angiogenin-1 promotes tissue repair in mice with oxygen-induced retinopathy of prematurity by promoting retinal stem cell proliferation and differentiation.	Oxygen	96-102	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	47-59
31106420-3	2019	In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells transfected with angiogenin-1 (Ang-1-BMSCs) affects the damaged retinal tissue of oxygen-induced retinopathy of prematurity (OIR-ROP) mice.	Oxygen	203-209	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	138-150
31106420-3	2019	In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells transfected with angiogenin-1 (Ang-1-BMSCs) affects the damaged retinal tissue of oxygen-induced retinopathy of prematurity (OIR-ROP) mice.	Oxygen	203-209	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	152-157
31430419-3	2019	Studies exploring underlying mechanisms of OSCC development have suggested free radicals such as reactive oxygen species generated by CS as contributing to OSCC, with effects enhanced by transition metal ions iron and copper contained in the saliva.	Oxygen	106-112	citrate synthase	Homo sapiens	134-136
32146621-4	2020	The comparison of the levels of reduced glutathione and 2.3-bisphosphoglicerate and activities of 5"-nucleotidase and Ca2+- and Na/K-ATPases attested to more rigorous control of the mechanism of oxygen delivery to tissues by erythrocytes after administration of ammonium chloride in a dose of 20 mg/kg.	Oxygen	195-201	5' nucleotidase, ecto	Rattus norvegicus	98-113
31119285-6	2020	We demonstrated that aldosterone augments pro-inflammatory cytokine production and reactive oxygen species production in monocyte-derived macrophages after re-stimulation, via the mineralocorticoid receptor.	Oxygen	92-98	nuclear receptor subfamily 3 group C member 2	Homo sapiens	180-206
31759538-4	2019	Villous explant cultures were used to study the effect of HR (8 h at 2% oxygen, followed by 16 h at 8% oxygen, two cycles) on the expression of sEH.	Oxygen	72-78	epoxide hydrolase 2	Homo sapiens	144-147
33122517-7	2020	CONCLUSIONS: Neutrophil gelatinase-associated lipocalin rescues intracellular reactive oxygen species during pancreatitis and promotes survival and regeneration of acinar cells.	Oxygen	87-93	lipocalin 2	Mus musculus	13-55
31759538-4	2019	Villous explant cultures were used to study the effect of HR (8 h at 2% oxygen, followed by 16 h at 8% oxygen, two cycles) on the expression of sEH.	Oxygen	103-109	epoxide hydrolase 2	Homo sapiens	144-147
31789109-4	2019	Although a neglected clinical parameter, pH has implications for relatively all pathologies of wound healing affecting oxygen release, angiogenesis, protease activity, bacterial toxicity and antimicrobial activity.	Oxygen	119-125	phenylalanine hydroxylase	Homo sapiens	41-43
30540219-1	2020	Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO2) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content.	Oxygen	69-75	CCAAT/enhancer binding protein zeta	Rattus norvegicus	122-125
33192549-11	2020	Moreover, USP22, SIRT1, or SLC7A11 elevation contributed to enhanced cardiomyocyte viability and attenuated ferroptosis-induced cell death in vitro, accompanied by increased GSH levels, as well as decreased reactive oxygen species production, lipid peroxidation, and iron accumulation.	Oxygen	216-222	solute carrier family 7 member 11	Rattus norvegicus	27-34
31901951-6	2020	We further verified that ACT001 elevated the levels of reactive oxygen species (ROS) by regulating NF-kappaB-targeted MnSOD.	Oxygen	64-70	superoxide dismutase 2	Homo sapiens	118-123
32023927-6	2020	We recently reported that protofibrils of Abeta1-42 disturbed membrane integrity by inducing reactive oxygen species generation and lipid peroxidation, resulting in decreased membrane fluidity, intracellular calcium dysregulation, depolarization, and synaptic toxicity.	Oxygen	102-108	AA1	Homo sapiens	42-48
31781339-5	2019	In SH-SY5Y-differentiated DAergic neurons under 1-methyl-4-phenylpyridinium (MPP+) treatment, NC001-8 remarkably reduced the levels of reactive oxygen species (ROS) and cleaved caspase 3; upregulated nuclear factor erythroid 2-related factor 2 (NRF2) and NAD(P)H dehydrogenase, quinone 1 (NQO1); and promoted neuronal viability.	Oxygen	144-150	down-regulator of transcription 1	Homo sapiens	94-101
31531426-1	2019	A photo- and dioxygen-enabled intermolecular radical Csp3-Nsp2 cross-coupling between guanidines and perfluoroalkyl iodides has been developed.	Oxygen	13-21	reticulon 2	Homo sapiens	58-62
32082261-0	2020	Hyperbaric Oxygen Ameliorates Insulin Sensitivity by Increasing GLUT4 Expression in Skeletal Muscle and Stimulating UCP1 in Brown Adipose Tissue in T2DM Mice.	Oxygen	11-17	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	116-120
33076390-5	2020	The results show that 12 phr of APP and 3 phr of KUIC were doped into UP to obtain a 28.0% limiting oxygen index (LOI) value.	Oxygen	100-106	uridine phosphorylase 1	Homo sapiens	70-72
32082261-3	2020	Therefore, we sought to determine whether hyperbaric oxygen would ameliorate insulin sensitivity by promoting glucose transporter type 4 (GLUT4) expression in muscle and by stimulating UCP1 in brown adipose tissue (BAT) in a streptozocin (STZ)-induced type 2 diabetes mellitus (T2DM) mouse model.	Oxygen	53-59	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	185-189
31997826-0	2020	MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway.	Oxygen	33-39	C-X-C motif chemokine ligand 12	Rattus norvegicus	142-171
31601814-5	2019	Defective autophagy in BRG1-deficient IECs results in excess reactive oxygen species (ROS), which leads to the defects in barrier integrity.	Oxygen	70-76	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	23-27
33102589-0	2020	Ephrin-A5 Is Involved in Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.	Oxygen	72-78	ephrin A5	Mus musculus	0-9
31549710-3	2019	By rationally tuning the Ni/Fe ratio in deep eutectic solvent plating solution, the best oxygen evolution reaction performance was achieved by a Ni75Fe25 catalyst, which requires only a 316 mV overpotential to reach a current density of 10 mA cm-2, while its Tafel slope is as low as 62 mV dec-1.	Oxygen	89-95	deleted in esophageal cancer 1	Homo sapiens	290-295
31991669-6	2020	The effect was due to the decrease of intracellular reactive oxygen species, consequent inhibition of the Akt/IKKalpha-beta/NF-kB axis, and reduced transcriptional activation of the Pgp promoter by p65/p50 NF-kB.	Oxygen	61-67	RELA proto-oncogene, NF-kB subunit	Homo sapiens	198-201
33102589-3	2020	The expression pattern and biological significance of Efna5 were investigated in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	98-104	ephrin A5	Mus musculus	54-59
32755566-6	2020	METTL3 knockout in vivo decreased avascular area and pathological neovascular tufts in an oxygen-induced retinopathy model and inhibited alkali burn-induced corneal neovascularization.	Oxygen	90-96	methyltransferase like 3	Mus musculus	0-6
32038231-13	2019	Molecular docking assay showed that the oxygen atom on the five-membered ring of ATLIII was capable of forming a hydrogen bond with Leu905-NH2 site of Jak3 protein.	Oxygen	40-46	Janus kinase 3	Mus musculus	151-155
31761381-5	2020	10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis.	Oxygen	353-359	cyclin dependent kinase 4	Homo sapiens	93-97
31314583-6	2019	Maximal O2 consumption (JO2: pmol s-1 mg-1) in Dia was higher with glutamate, malate, and succinate (Dia 399 +- 127, RG 148 +- 60; P &lt; 0.05) and palmitoyl-CoA + carnitine (Dia 15 +- 5, RG 7 +- 1; P &lt; 0.05) than in RG, but not different between muscles when JO2 was normalized to citrate synthase activity.	Oxygen	8-10	citrate synthase	Mus musculus	285-301
31314594-11	2019	In addition, Ucp5 knockdown induced the up-regulation of reactive oxygen species levels in a rat brain glioma cell line, whereas reduced O2 consumption was observed with Tfam knockdown.	Oxygen	137-139	transcription factor A, mitochondrial	Rattus norvegicus	170-174
31591594-6	2019	Mechanistically, the impact of 3D zwitterionic hydrogel culture on mitigating HSPC differentiation and promoting self-renewal might result from an inhibition of excessive reactive oxygen species (ROS) production via suppression of O2-related metabolism.	Oxygen	180-186	proteasome 20S subunit alpha 7	Homo sapiens	78-82
31940867-6	2020	Overall, we found that SOD2 siRNA transfection in the spheroid form of MSCs increases the expression of apoptotic genes and decreases the clearance of mitochondrial reactive oxygen species (ROS).	Oxygen	174-180	superoxide dismutase 2	Homo sapiens	23-27
33028529-3	2020	Here, we found that DSBs in oxygen/glucose-deprived (OGD) neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.	Oxygen	28-34	WD repeat containing antisense to TP53	Homo sapiens	120-126
31936545-7	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	83-89	heme oxygenase 2	Homo sapiens	39-53
31936545-7	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	83-89	heme oxygenase 2	Homo sapiens	184-198
31533957-1	2019	Cytochrome c oxidase (CcO), a membrane enzyme in the respiratory chain, catalyzes oxygen reduction by coupling electron and proton transfer through the enzyme with a proton pump across the membrane.	Oxygen	82-88	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
31936545-7	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	210-216	heme oxygenase 2	Homo sapiens	39-53
31533957-1	2019	Cytochrome c oxidase (CcO), a membrane enzyme in the respiratory chain, catalyzes oxygen reduction by coupling electron and proton transfer through the enzyme with a proton pump across the membrane.	Oxygen	82-88	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
31936545-7	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	210-216	heme oxygenase 2	Homo sapiens	184-198
33082910-0	2020	Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.	Oxygen	91-97	voltage dependent anion channel 1	Homo sapiens	26-31
31936545-16	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	83-89	heme oxygenase 2	Homo sapiens	39-53
31936545-16	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	83-89	heme oxygenase 2	Homo sapiens	184-198
31936545-16	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	210-216	heme oxygenase 2	Homo sapiens	39-53
31936545-16	2020	The remarkable correlation between the HO 2   and O 2   - production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO 2   and O 2   - in the oxygen sensitization effect.	Oxygen	210-216	heme oxygenase 2	Homo sapiens	184-198
30819616-3	2019	Loss of MnSOD led to specific increases in mitochondrial O2- with no evident changes in hydrogen peroxide (H2O2), peroxynitrite (ONOO-), or copper/zinc superoxide dismutase (CuZnSOD) levels.	Oxygen	57-60	superoxide dismutase 2	Homo sapiens	8-13
32830535-7	2020	Mitochondrial function, as assessed by mitochondrial cytochrome c levels, mitochondrial membrane potential, oxygen consumption, and ATP levels, was significantly reduced in the PDI inhibited cells.	Oxygen	108-114	prolyl 4-hydroxylase subunit beta	Homo sapiens	177-180
31436082-5	2019	Here, we report a multifunctional oxygen-reporting fibrous matrix fabricated through encapsulation of a hydrophilic oxygen-sensitive, two-photon excitable phosphorescent probe, PtP-C343, in the core of fibers during coaxial electrospinning.	Oxygen	34-40	protein tyrosine phosphatase receptor type U	Homo sapiens	177-180
31436082-5	2019	Here, we report a multifunctional oxygen-reporting fibrous matrix fabricated through encapsulation of a hydrophilic oxygen-sensitive, two-photon excitable phosphorescent probe, PtP-C343, in the core of fibers during coaxial electrospinning.	Oxygen	116-122	protein tyrosine phosphatase receptor type U	Homo sapiens	177-180
31799573-3	2020	The best oxygen evolution reaction (OER) performance was achieved by 25 h-Ni3S2-NF catalyst, which required merely 241 mV overpotential to deliver a current density of 20 mA cm-2, and its Tafel slope was as low as ~40 mV dec-1, which was superior to most nickel-based catalysts, in 1 M KOH electrolyte.	Oxygen	9-15	deleted in esophageal cancer 1	Homo sapiens	221-226
32597024-3	2020	The effects of B-type natriuretic peptide (BNP) in suppressing superoxide (O2 - ) release from neutrophils are transiently impaired in acute heart failure.	Oxygen	75-79	natriuretic peptide B	Homo sapiens	15-41
31907363-10	2020	Wnt7a protein treatment increased beta-catenin and claudin-5 expression in endothelial cells after oxygen-glucose deprivation, which was similar to the results of the conditioned medium treatment of oligodendrocyte precursor cells on endothelial cells.	Oxygen	99-105	wingless-type MMTV integration site family, member 7A	Mus musculus	0-5
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	ECSIT signaling integrator	Homo sapiens	102-107
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	LOC222344	Homo sapiens	109-141
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	ECSIT signaling integrator	Homo sapiens	200-205
32597024-3	2020	The effects of B-type natriuretic peptide (BNP) in suppressing superoxide (O2 - ) release from neutrophils are transiently impaired in acute heart failure.	Oxygen	75-79	natriuretic peptide B	Homo sapiens	43-46
31432823-1	2019	Solid-state Li1+xAlxGe2-x(PO4)3 electrolytes with high ionic conductivity were prepared and successfully applied in lithium-oxygen batteries (LOBs).	Oxygen	124-130	transglutaminase 1	Homo sapiens	12-15
31612077-1	2019	Recent studies have reported that the transient receptor potential V1 ion channel (TRPV1), a pain generator on sensory neurons, is activated and potentiated by NADPH oxidase-generated reactive oxygen species (ROS).	Oxygen	193-199	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
31731193-12	2020	In addition, VIP inhibited the generation of reactive oxygen species in macrophages by decreasing NOX1 and NOX2 expression.	Oxygen	54-60	NADPH oxidase 1	Mus musculus	98-102
31731193-12	2020	In addition, VIP inhibited the generation of reactive oxygen species in macrophages by decreasing NOX1 and NOX2 expression.	Oxygen	54-60	cytochrome b-245, beta polypeptide	Mus musculus	107-111
32497588-4	2020	To understand how X. laevis survives under such stress, we studied the regulation pattern of key mitogen-activated protein kinases (MAPK) and their downstream transcription factors, along with several heat shock proteins in the oxygen sensitive brain and heart tissue of X. laevis under dehydration stress.	Oxygen	228-234	mitogen-activated protein kinase 1 S homeolog	Xenopus laevis	132-136
32597024-4	2020	We also evaluated the extent and duration of BNP-induced suppression of O2 - release post-TTS.	Oxygen	72-74	natriuretic peptide B	Homo sapiens	45-48
31686854-11	2019	Meantime, OGDH knockdown cells showed decreased mitochondrial membrane potential, oxygen consumption rate, intracellular ATP product, and increased ROS level and NADP+/NADPH ratio.	Oxygen	82-88	oxoglutarate dehydrogenase	Homo sapiens	10-14
32597024-8	2020	Relative to control subjects, in TTS patients, BNP suppression of both phorbol myristate acetate and N-formyl-methionyl-leucyl-phenylalanine-induced O2 - release was impaired acutely (P < 0.05 for both); this did not improve over the 3-month recovery period, despite treatment with conventional anti-failure medication in 85% of patients.	Oxygen	149-151	natriuretic peptide B	Homo sapiens	47-50
32597024-10	2020	CONCLUSIONS: (1) While TTS is associated with marked and prolonged release of BNP, there is virtually total loss of the ability of BNP to suppress neutrophil O2 - release and its impact on tissue inflammation.	Oxygen	158-162	natriuretic peptide B	Homo sapiens	131-134
30556496-3	2020	HO utilizes three oxygen molecules (O2) and seven electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR) to open the heme ring and BVR reduces BV through the use of NAD(P)H.	Oxygen	18-24	biliverdin reductase A	Homo sapiens	141-144
31601141-5	2020	Endothelial levels of miR-98 were significantly altered following ischemia/reperfusion insults, both in vivo and in vitro, transient middle cerebral artery occlusion (tMCAO), and oxygen-glucose deprivation (OGD), respectively.	Oxygen	179-193	microRNA 98	Mus musculus	22-28
30556496-3	2020	HO utilizes three oxygen molecules (O2) and seven electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR) to open the heme ring and BVR reduces BV through the use of NAD(P)H.	Oxygen	36-38	biliverdin reductase A	Homo sapiens	141-144
31500697-1	2019	Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF.	Oxygen	60-66	egl-9 family hypoxia inducible factor 2	Homo sapiens	72-86
31500697-1	2019	Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF.	Oxygen	98-104	egl-9 family hypoxia inducible factor 2	Homo sapiens	72-86
30686644-10	2020	In a subgroup analysis of patients with pulmonary arterial hypertension (n = 34) there was a stronger correlation of emPHasis-10 score with mPAP (r = 0.86, p &lt; 0.001) and PVR (r = 0.69, p &lt; 0.01), but no correlation with cardiac index and mixed venous oxygen saturation.	Oxygen	258-264	phospholipid phosphatase 1	Mus musculus	140-144
32748332-4	2020	In this present study we demonstrate that similar to mouse bone marrow (BM) and human cord blood, collection and processing of mouse Granulocyte Colony Stimulating Factor (G-CSF)-, AMD3100/Plerixafor- or G-CSF plus AMD3100/Plerixafor-mobilized HSCs in 3% O2 results in enhanced numbers of rigorously-defined phenotypic and for G-CSF - and G-CSF plus AMD3100/Plerixafor - mPB enhanced functionally-engrafting HSCs.	Oxygen	255-257	colony stimulating factor 3 (granulocyte)	Mus musculus	204-209
31604080-3	2020	Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial metabolism in tumors, and promotes tumor metabolic reprogramming for their adaption to the microenvironment stress imposed by oxygen and nutrients deprivation.	Oxygen	223-229	galectin 3	Homo sapiens	10-20
31510109-3	2019	In GBs, mTORC1 inhibitors such as rapamycin have performed poorly in clinical trials, and in vitro protect GB cells from nutrient and oxygen deprivation.	Oxygen	134-140	CREB regulated transcription coactivator 1	Mus musculus	8-14
31510109-7	2019	However, under hypoxic and nutrient-poor conditions mTORC1/2 inhibitors displayed even stronger cytoprotective effects than rapamycin by reducing oxygen and glucose consumption.	Oxygen	146-152	CREB regulated transcription coactivator 1	Mus musculus	52-58
32748332-4	2020	In this present study we demonstrate that similar to mouse bone marrow (BM) and human cord blood, collection and processing of mouse Granulocyte Colony Stimulating Factor (G-CSF)-, AMD3100/Plerixafor- or G-CSF plus AMD3100/Plerixafor-mobilized HSCs in 3% O2 results in enhanced numbers of rigorously-defined phenotypic and for G-CSF - and G-CSF plus AMD3100/Plerixafor - mPB enhanced functionally-engrafting HSCs.	Oxygen	255-257	colony stimulating factor 3 (granulocyte)	Mus musculus	204-209
32748332-4	2020	In this present study we demonstrate that similar to mouse bone marrow (BM) and human cord blood, collection and processing of mouse Granulocyte Colony Stimulating Factor (G-CSF)-, AMD3100/Plerixafor- or G-CSF plus AMD3100/Plerixafor-mobilized HSCs in 3% O2 results in enhanced numbers of rigorously-defined phenotypic and for G-CSF - and G-CSF plus AMD3100/Plerixafor - mPB enhanced functionally-engrafting HSCs.	Oxygen	255-257	colony stimulating factor 3 (granulocyte)	Mus musculus	204-209
31278893-12	2019	These results implied that exogenous NAD administration promoted Sirt5-mediated SDH-a desuccinylation and decreased the activity of SDH-a, which attenuated the succinate accumulation during ischemia and its depleting rate during reperfusion and finally alleviated reactive oxygen species generation.	Oxygen	273-279	succinate dehydrogenase complex flavoprotein subunit A	Rattus norvegicus	132-137
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	129-135	superoxide dismutase 2	Homo sapiens	18-40
32961913-1	2020	BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis.	Oxygen	82-88	thyroglobulin	Mus musculus	160-173
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	129-135	superoxide dismutase 2	Homo sapiens	42-46
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	129-135	superoxide dismutase 2	Homo sapiens	51-81
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	272-274	superoxide dismutase 2	Homo sapiens	18-40
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	272-274	superoxide dismutase 2	Homo sapiens	42-46
31494578-5	2020	This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2.	Oxygen	272-274	superoxide dismutase 2	Homo sapiens	51-81
31494578-6	2020	Measurement of hydroethidine oxidation showed a significant increase in O2 -  levels in the patient"s skin fibroblasts, as compared with controls, and this was paralleled by reduced catalytic activity of SOD2 in patient fibroblasts and muscle.	Oxygen	72-74	superoxide dismutase 2	Homo sapiens	204-208
31494578-8	2020	CONCLUSION: Our results provide evidence that defective SOD2 may lead to toxic increases in the levels of damaging oxygen radicals in the neonatal heart, which can result in rapidly developing heart failure and death.	Oxygen	115-121	superoxide dismutase 2	Homo sapiens	56-60
32526757-1	2020	INTRODUCTION: The exocytosis of cyclophilin A (CyPA) by a vesicular pathway in response to reactive oxygen species has been determined.	Oxygen	100-106	peptidylprolyl isomerase A	Rattus norvegicus	32-45
32526757-1	2020	INTRODUCTION: The exocytosis of cyclophilin A (CyPA) by a vesicular pathway in response to reactive oxygen species has been determined.	Oxygen	100-106	peptidylprolyl isomerase A	Rattus norvegicus	47-51
31551768-7	2019	The reactive oxygen species levels induced by Fe(PIP)3SO4 were measured by 2"-deoxycoformycin (DCF) probe; ABTS assay was utilized to examine the radical scavenge capacity of Fe(PIP)3SO4.	Oxygen	13-19	prolactin induced protein	Mus musculus	49-52
31481746-5	2019	For a collision between O2 and Mg2, the electronic excitation energy increased with the incident kinetic energy.	Oxygen	24-26	mucin 7, secreted	Homo sapiens	31-34
30908945-0	2019	Alterations in myocardial connexin-43 and matrix metalloproteinase-2 signaling in response to pregnancy and oxygen deprivation of Wistar rats: a pilot study 1.	Oxygen	108-114	matrix metallopeptidase 2	Rattus norvegicus	42-68
32947927-4	2020	The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardial infarction.	Oxygen	335-341	angiotensin converting enzyme 2	Homo sapiens	109-140
31081204-7	2019	As expected, substrate-reduced Dld2 very slowly reacted with oxygen or the artificial electron acceptor 2,6-dichlorophenol indophenol.	Oxygen	61-67	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	31-35
31081204-8	2019	However, photoreduced Dld2 was rapidly reoxidized by oxygen, suggesting that the reaction products, that is, alpha-ketoglutarate and pyruvate, "lock" the reduced enzyme in an unreactive state.	Oxygen	53-59	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	22-26
31081204-10	2019	Therefore, we conclude that the formation of a product-reduced Dld2 complex suppresses electron transfer to dioxygen but favors the rapid reduction in yETF, thus preventing the loss of electrons and the generation of reactive oxygen species.	Oxygen	108-116	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	63-67
31081204-10	2019	Therefore, we conclude that the formation of a product-reduced Dld2 complex suppresses electron transfer to dioxygen but favors the rapid reduction in yETF, thus preventing the loss of electrons and the generation of reactive oxygen species.	Oxygen	110-116	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	63-67
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Oxygen	293-299	superoxide dismutase 2	Homo sapiens	1381-1385
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	eukaryotic translation initiation factor 2A	Mus musculus	207-254
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	eukaryotic translation initiation factor 2A	Mus musculus	256-265
31557719-3	2020	As both H2S and reactive oxygen species (such as H2O2) are major regulators of Caenorhabditis elegans lifespan and stress resistance, we hypothesized that a SELENBP1 ortholog in C. elegans would likely be involved in regulating these aspects.	Oxygen	25-31	selenium binding protein 1	Homo sapiens	157-165
32432367-3	2020	Thus, the reaction with O2 proceeds much faster and afterwards the first structural characterization of an iron(II) eta2 -O,O-sulfinate product became possible.	Oxygen	24-26	DNA polymerase iota	Homo sapiens	116-120
31903111-0	2020	Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death.	Oxygen	68-74	coactivator-associated arginine methyltransferase 1	Mus musculus	14-48
31782466-13	2019	In addition, MFeMnCNH demonstrated a low overpotential of 464 mV and fast kinetics with a Tafel slope of 64.6 mV dec-1 as an electrocatalyst for the oxygen evolution reaction in 1.0 M KOH.	Oxygen	149-155	deleted in esophageal cancer 1	Homo sapiens	113-118
31286450-0	2019	Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity.	Oxygen	78-84	peroxiredoxin 6	Mus musculus	51-66
31286450-12	2019	The influences of IE-HBO on Prdx6 may form an important basis for its protection against oxygen toxicity.	Oxygen	89-95	peroxiredoxin 6	Mus musculus	28-33
31108306-10	2019	Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group.	Oxygen	41-47	tubulin beta 3 class III	Homo sapiens	165-170
32927860-2	2020	Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain.	Oxygen	31-37	phototropin 2	Arabidopsis thaliana	0-5
30690929-7	2019	The study demonstrated a correlation between venular retinal blood oxygen saturation and proangiogenic factors HGF (r = 0.558, p = 0.038), Ang2 (r = 0.556, p = 0.039) and EGF (r = -0.554, p = 0.040), but did not find any correlation for IL-8 (r = 0.330, p = 0.249) even though this biomarker was significantly higher in the diabetic group.	Oxygen	67-73	hepatocyte growth factor	Homo sapiens	111-114
30690929-7	2019	The study demonstrated a correlation between venular retinal blood oxygen saturation and proangiogenic factors HGF (r = 0.558, p = 0.038), Ang2 (r = 0.556, p = 0.039) and EGF (r = -0.554, p = 0.040), but did not find any correlation for IL-8 (r = 0.330, p = 0.249) even though this biomarker was significantly higher in the diabetic group.	Oxygen	67-73	angiopoietin 2	Homo sapiens	139-143
30880408-7	2019	This new methodology enabled the quantitative assessment of the interaction of Pdi1p and Ero1p in vitro by measuring oxygen consumption and reoxidation of reduced RNase A.	Oxygen	117-123	protein disulfide isomerase PDI1	Saccharomyces cerevisiae S288C	79-84
31882939-5	2019	In addition, lactate, the levels of which are elevated in plasma of HFD-fed mice following LKU4 administration, elicited the same effect on the interaction between PPARgamma and PGC-1alpha in 3T3-L1 adipocytes, leading to a brown-like adipocyte phenotype that included enhanced Ucp1 expression, mitochondrial levels and function, and oxygen consumption rate.	Oxygen	334-340	peroxisome proliferator activated receptor gamma	Mus musculus	164-173
31882939-5	2019	In addition, lactate, the levels of which are elevated in plasma of HFD-fed mice following LKU4 administration, elicited the same effect on the interaction between PPARgamma and PGC-1alpha in 3T3-L1 adipocytes, leading to a brown-like adipocyte phenotype that included enhanced Ucp1 expression, mitochondrial levels and function, and oxygen consumption rate.	Oxygen	334-340	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	178-188
31949877-6	2019	Additionally, BLM- and TGF-beta1-evoked cellular reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, and cell apoptosis were rescued by MenSCs-Exo in vivo and in vitro.	Oxygen	58-64	transforming growth factor, beta 1	Mus musculus	23-32
31614143-11	2019	The results indicate that neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	114-120	neurotensin receptor 1	Homo sapiens	26-48
32898488-2	2020	A new study shows that trafficking of TRPA1 channels in and out of the cell membrane in brainstem astrocytes contributes to their role as central respiratory oxygen sensors.	Oxygen	158-164	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
31697018-1	2019	Inspiration from copper-based oxygen reduction biocatalysts, we have studied the electrocatalytic behavior of a Cu-based MOF (Cu-BTT, compound 1) for Oxygen Reduction Reaction (ORR) in alkaline medium.	Oxygen	30-36	lysine acetyltransferase 8	Homo sapiens	121-124
31697018-1	2019	Inspiration from copper-based oxygen reduction biocatalysts, we have studied the electrocatalytic behavior of a Cu-based MOF (Cu-BTT, compound 1) for Oxygen Reduction Reaction (ORR) in alkaline medium.	Oxygen	150-156	lysine acetyltransferase 8	Homo sapiens	121-124
31292775-1	2019	Copper-zinc superoxide dismutase (Sod1) is a critical antioxidant enzyme that rids the cell of reactive oxygen through the redox cycling of a catalytic copper ion provided by its copper chaperone (Ccs).	Oxygen	104-110	copper chaperone for superoxide dismutase	Homo sapiens	197-200
32899962-6	2020	Our results show that the MPC1def flies display significantly reduced climbing capacity, pyruvate-induced oxygen consumption, and enzymatic activities of pyruvate kinase, alanine aminotransferase, and citrate synthase.	Oxygen	106-112	Mitochondrial pyruvate carrier	Drosophila melanogaster	26-33
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Oxygen	136-142	transcription factor binding to IGHM enhancer 3	Homo sapiens	68-72
31693378-3	2019	Herein, we report an efficient strategy to construct noble metal/2D MOF heterostructures, featuring the utilization of surface oxygen sites from uncoordinated MOF ligands.	Oxygen	127-133	lysine acetyltransferase 8	Homo sapiens	68-71
31693378-3	2019	Herein, we report an efficient strategy to construct noble metal/2D MOF heterostructures, featuring the utilization of surface oxygen sites from uncoordinated MOF ligands.	Oxygen	127-133	lysine acetyltransferase 8	Homo sapiens	159-162
32693188-10	2020	In macrophages, expression of LACC1 was required for toll like receptor-induced uptake of bacteria, which required PDK1, and MAPK- and nuclear factor kappaB-dependent induction of reactive oxygen species, reactive nitrogen species, and autophagy.	Oxygen	189-195	laccase domain containing 1	Mus musculus	30-35
31857853-3	2019	Besides their effects on regulation of mTORC1/2, SESTRINs also control the accumulation of reactive oxygen species, cell death, and mitophagy.	Oxygen	100-106	CREB regulated transcription coactivator 2	Mus musculus	39-47
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	251-255
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	E74 like ETS transcription factor 1	Homo sapiens	257-261
30779122-9	2019	Changes in oxygen concentration, glucose availability, and cell cycle regulate HIGD2A expression.	Oxygen	11-17	HIG1 domain family, member 2A	Mus musculus	79-85
31192511-8	2019	Moreover, miR-210 levels decreased in EVs isolated from the culture medium under high oxygen tension suggesting that this miRNA can be used as a marker for normoxia since it is associated with low oxygen tension.	Oxygen	86-92	microRNA 210	Bos taurus	10-17
31192511-8	2019	Moreover, miR-210 levels decreased in EVs isolated from the culture medium under high oxygen tension suggesting that this miRNA can be used as a marker for normoxia since it is associated with low oxygen tension.	Oxygen	197-203	microRNA 210	Bos taurus	10-17
31350594-4	2019	Following internalization of oxLDL, LOX-1 starts a vicious cycle from activation of proinflammatory signaling pathways, subsequently advancing an expanded responsive oxygen species arrangement and secretion of proinflammatory cytokines.	Oxygen	166-172	oxidized low density lipoprotein receptor 1	Homo sapiens	36-41
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	CD300a molecule	Homo sapiens	357-363
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	protein kinase D2	Homo sapiens	365-370
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	251-255
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	E74 like ETS transcription factor 1	Homo sapiens	257-261
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	CD300a molecule	Homo sapiens	357-363
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	protein kinase D2	Homo sapiens	365-370
31823095-0	2019	LncRNA MALAT1 Promotes Oxygen-Glucose Deprivation and Reoxygenation Induced Cardiomyocytes Injury Through Sponging miR-20b to Enhance beclin1-Mediated Autophagy.	Oxygen	23-29	microRNA 20b	Homo sapiens	115-122
31990056-3	2020	The present study demonstrated that miR-26a was downregulated in ST-elevation MI (STEMI) patients and oxygen-glucose deprivation (OGD)-treated H9c2 cells.	Oxygen	102-116	microRNA 26a-1	Homo sapiens	36-43
31357724-3	2019	The optimal stable photocurrent density of the 50-nm-thick amorphous SnS2 film fabricated at 140  C was 51.5 microA/cm2 at an oxygen evolution reaction (0.8 V vs. saturated calomel electrode (SCE)).	Oxygen	126-132	sodium voltage-gated channel alpha subunit 11	Homo sapiens	69-73
32511787-8	2020	SBP1 overexpression reduced oxygen consumption in these cells and increased the activation of AMP-activated protein kinase (AMPK), a major regulator of energy homeostasis.	Oxygen	28-34	selenium binding protein 1	Homo sapiens	0-4
31188590-5	2019	Moreover, the reductive carbon will result in abundant oxygen (O*) defects, which could help to capture the migratory Pd1 species, leaving a sintering-resistant Pd1@ZrO2 catalyst via atom trapping.	Oxygen	55-61	programmed cell death 1	Homo sapiens	118-121
31188590-5	2019	Moreover, the reductive carbon will result in abundant oxygen (O*) defects, which could help to capture the migratory Pd1 species, leaving a sintering-resistant Pd1@ZrO2 catalyst via atom trapping.	Oxygen	55-61	programmed cell death 1	Homo sapiens	161-164
31270843-5	2019	Knockdown of HK2 also increased O2 consumption while decreasing the extracellular level of lactate and the phosphorylation of p38-mitogen-activated protein kinase (MAPK).	Oxygen	32-34	hexokinase 2	Homo sapiens	13-16
31655089-10	2019	Correspondingly, treating C57BL/6N mice with Pref-1 resulted in reduced expression of thermogenic and beige fat markers, a reduced rate of oxygen consumption, blunting of UCP1 expression and beige fat formation in iWAT in response to cold exposure or CL316,243 injection compared to the untreated mice.	Oxygen	139-145	delta like non-canonical Notch ligand 1	Mus musculus	45-51
32255719-3	2020	The HIFs are negatively regulated by O2-dependent hydroxylation and ubiquitination by prolyl hydroxylase domain (PHD) proteins and the von Hippel-Lindau (VHL) protein.	Oxygen	37-39	von Hippel-Lindau tumor suppressor	Homo sapiens	135-152
31556968-2	2019	Here, we reported that inhibition of MALT1 protease in ABC-DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate.	Oxygen	137-143	MALT1 paracaspase	Homo sapiens	37-51
31295884-2	2019	Cigarette smoke (CS) exposure provokes alterations in TSPO expression as well as upregulation of its related functions such as mitochondrial membrane potential (DeltapsiM) and reactive oxygen species generation, which are associated with cell death.	Oxygen	185-191	citrate synthase	Homo sapiens	0-15
31295884-2	2019	Cigarette smoke (CS) exposure provokes alterations in TSPO expression as well as upregulation of its related functions such as mitochondrial membrane potential (DeltapsiM) and reactive oxygen species generation, which are associated with cell death.	Oxygen	185-191	citrate synthase	Homo sapiens	17-19
31556968-2	2019	Here, we reported that inhibition of MALT1 protease in ABC-DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate.	Oxygen	137-143	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	55-58
32703402-5	2020	Here, we reported that TRIM62 expression was markedly up-regulated in oxygen and glucose deprivation (OGD)-treated microglial cells.	Oxygen	70-76	tripartite motif-containing 62	Mus musculus	23-29
31630079-0	2019	Galectin-1 modulation of neutrophil reactive oxygen species production depends on the cell activation state.	Oxygen	45-51	lectin, galactose binding, soluble 1	Mus musculus	0-10
31638263-10	2019	Further investigation found that forced expression of miR-455 reduced the level of reactive oxygen species (ROS) and malondialdehyde (MDA), while the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were promoted.	Oxygen	92-98	microRNA 455	Homo sapiens	54-61
31576217-3	2019	Moreover, X-ray diffraction at 100 K under a high pressure of dioxygen, a physiological ligand of Ngb, unravelled the existence of a storage site for O2 in Ngb which coincides with Xe-III, a previously described docking site for xenon or krypton.	Oxygen	62-70	neuroglobin	Mus musculus	98-101
31576217-3	2019	Moreover, X-ray diffraction at 100 K under a high pressure of dioxygen, a physiological ligand of Ngb, unravelled the existence of a storage site for O2 in Ngb which coincides with Xe-III, a previously described docking site for xenon or krypton.	Oxygen	62-70	neuroglobin	Mus musculus	156-159
31208986-8	2019	Furthermore, PDK1 knockdown decreased the oxygen consumption rate in H9C2 cells as determined using a Seahorse XF96 Analyzer.	Oxygen	42-48	pyruvate dehydrogenase kinase 1	Rattus norvegicus	13-17
31410187-7	2019	Conversely, at higher oxygen levels, the increased expression of TCF4 exerts a transcriptional inhibitory function on the same genomic regions, thus counteracting differentiation.	Oxygen	22-28	transcription factor 4	Homo sapiens	65-69
31544319-6	2019	However, the expression of NOTCH1 and E2F1 was higher in female embryos cultured in high oxygen level.	Oxygen	89-95	notch receptor 1	Bos taurus	27-33
32820168-7	2020	The obtained catalyst exhibits fast kinetics for O2 adsorption and activation with an ultralow Tafel slope of 27.5 mV dec-1 and a remarkable half-wave potential of 0.90 V. This work offers a new strategy to regulate catalytic sites for better performance.	Oxygen	49-51	deleted in esophageal cancer 1	Homo sapiens	118-123
31282845-6	2019	Arecoline activated YAP by increasing reactive oxygen species levels and inducing the PERK pathway (eukaryotic translation initiation factor 2 alpha kinase 3), resulting in the initiation of EndMT and leading to OSF.	Oxygen	47-53	Yes1 associated transcriptional regulator	Homo sapiens	20-23
31771164-0	2019	Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model.	Oxygen	99-105	fibroblast growth factor 21	Mus musculus	75-80
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Oxygen	9-15	gasdermin D	Homo sapiens	168-179
32806915-8	2020	However, HO2  produced via the oxygen reduction reaction in the EO process plays a major role in As(III) oxidation, which explains the lower reaction rate in the absence of S(IV).	Oxygen	31-37	heme oxygenase 2	Homo sapiens	9-12
31237394-3	2019	Herein, using on-line differential electrochemical mass spectrometry, we show that oxygen-containing carbon surface groups present on high-surface aera carbon, Vulcan XC72 or reinforced graphite are oxidized at PEMFC anode-relevant potential (E=0.1 V vs. the reversible hydrogen electrode, RHE), but not at E=0.4 V vs. RHE.	Oxygen	83-89	factor interacting with PAPOLA and CPSF1	Homo sapiens	290-293
31237394-3	2019	Herein, using on-line differential electrochemical mass spectrometry, we show that oxygen-containing carbon surface groups present on high-surface aera carbon, Vulcan XC72 or reinforced graphite are oxidized at PEMFC anode-relevant potential (E=0.1 V vs. the reversible hydrogen electrode, RHE), but not at E=0.4 V vs. RHE.	Oxygen	83-89	factor interacting with PAPOLA and CPSF1	Homo sapiens	319-322
31140732-0	2019	Hierarchically Porous Co/Cox My (M = P, N) as an Efficient Mott-Schottky Electrocatalyst for Oxygen Evolution in Rechargeable Zn-Air Batteries.	Oxygen	93-99	cytochrome c oxidase subunit 8A	Homo sapiens	25-28
31140732-2	2019	Herein, a salt-templated strategy is proposed to construct novel multicomponent Co/Cox My (M = P, N) hybrids with outstanding electrocatalytic performance for the oxygen evolution reaction (OER).	Oxygen	163-169	cytochrome c oxidase subunit 8A	Homo sapiens	83-86
31184338-5	2019	It is found that the surface phase diagrams are closely related to the reducibility of M cations, which is reflected in the oxygen adsorption energy and oxygen vacancy formation energy on the MO2- and LaO-terminated surfaces and can be measured by the third ionization energies of the M2+ cations.	Oxygen	124-130	interleukin 4 induced 1	Homo sapiens	201-204
31799200-13	2019	TIGAR knockdown led to increased ROS production, elevated mitochondrial ATP production, and phosphorus oxygen ratios.	Oxygen	92-109	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	155-161	neutrophil cytosolic factor 2	Homo sapiens	69-76
31697484-3	2019	The prepared MoS2/SnS2/r-GO showed significant photoexcitation of photosensitive oxygen (ROS) by electron spin resonance spectroscopy, demonstrating that superoxide radicals ( O2-), pores, and hydroxyl radicals ( OH) are the main active species.	Oxygen	81-87	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
31184338-5	2019	It is found that the surface phase diagrams are closely related to the reducibility of M cations, which is reflected in the oxygen adsorption energy and oxygen vacancy formation energy on the MO2- and LaO-terminated surfaces and can be measured by the third ionization energies of the M2+ cations.	Oxygen	153-159	interleukin 4 induced 1	Homo sapiens	201-204
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	174-180	neutrophil cytosolic factor 2	Homo sapiens	69-76
30993849-0	2019	Oxygen Evolution Electrocatalysis of a Single MOF-Derived Composite Nanoparticle on the Tip of a Nanoelectrode.	Oxygen	0-6	lysine acetyltransferase 8	Homo sapiens	46-49
32823749-2	2020	Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes.	Oxygen	65-71	clock circadian regulator	Homo sapiens	98-103
31249587-1	2019	Many alien aquatic plants are deliberately introduced because they have economic, ornamental, or environmental values; however, they may also negatively affect aquatic ecosystems, by blocking rivers, restricting aquatic animals and plants by decreasing dissolved oxygen, and reducing native biodiversity.	Oxygen	263-269	COP9 signalosome subunit 2	Homo sapiens	5-10
31705020-3	2019	Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production of 4-hydroxynonenal, which was converted to fatty acids with NADH production by ALDH3A1, resulting in further fatty acid oxidation.	Oxygen	62-68	aldehyde dehydrogenase 3 family member A1	Homo sapiens	187-194
32725021-6	2020	As an electrocatalyst, N-graphyne exhibited an overpotential of 280 mV at 100 mA cm-2 and a Tafel slope of 122 mV dec-1 for the oxygen evolution reaction with highly stable morphology and electrocatalytic performance.	Oxygen	128-134	deleted in esophageal cancer 1	Homo sapiens	114-119
31699987-1	2019	First-row transition metal-based catalysts have been developed for the oxygen evolution reaction (OER) during the past years, however, such catalysts typically operate at overpotentials (eta) significantly above thermodynamic requirements.	Oxygen	71-77	endothelin receptor type A	Homo sapiens	22-25
31700134-6	2019	iPLA2gamma KO GECs showed a reduced oxygen consumption rate and increased phosphorylation of AMP kinase (pAMPK), consistent with mitochondrial dysfunction.	Oxygen	36-42	patatin-like phospholipase domain containing 8	Mus musculus	0-10
31781313-11	2019	Sestrin2 was positively correlated with apnea/hypopnea index (AHI) oxygen desaturation index, while negatively correlated with mean oxygen saturation.	Oxygen	67-73	sestrin 2	Homo sapiens	0-8
31781313-11	2019	Sestrin2 was positively correlated with apnea/hypopnea index (AHI) oxygen desaturation index, while negatively correlated with mean oxygen saturation.	Oxygen	132-138	sestrin 2	Homo sapiens	0-8
31211019-6	2019	Deoxygenated haemoglobin ( HHb) in the pre-frontal cortex (FH), gastrocnemius (GN), left vastus lateralis (LVL) and the right vastus lateralis (RVL) muscles, systemic oxygen utilisation (VO2), systolic (SBP) and diastolic (DBP) blood pressure and physical activity enjoyment scale (PACES) were measured during the experiment conditions.	Oxygen	2-8	selenium binding protein 1	Homo sapiens	203-206
30970162-4	2019	With the addition of PDA, Ag2 S had more opportunities to react with surrounding O2 , which was demonstrated by typical triplet electron spin resonance (ESR) analysis.	Oxygen	81-83	angiotensin II receptor type 1	Homo sapiens	26-31
30954471-9	2019	Ex vivo cultured slices also were sensitive to hypoxia because carbonic anhydrase IX and zinc finger E-box binding homeobox 1 (Zeb1) protein levels increased in 1% oxygen.	Oxygen	164-170	carbonic anhydrase 9	Homo sapiens	63-84
31518161-8	2019	In addition, activity of complex IV was lower and production of reactive oxygen species was augmented in the mitochondria of IL-18KO aorta.	Oxygen	73-79	interleukin 18	Mus musculus	125-130
32831639-10	2020	Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r = -0.238, P = 0.003) and oxygen desaturation index (r = -0.234, P = 0.004) and positively correlated with left ventricular ejection fraction (r = 0.251, P = 0.004) in all subjects.	Oxygen	110-116	C1q and TNF related 9	Homo sapiens	33-38
31908895-13	2019	ATRX and TP53 are important nodes in the network and have potential links with the blood oxygen imbalance.	Oxygen	89-95	ATRX chromatin remodeler	Homo sapiens	0-4
30788515-11	2019	Rdh1 ablation also decreased mitochondrial proteins, including CYCS and UCP1, the mitochondria oxygen consumption rate, and disrupted the mitochondria membrane potential, further reflecting impaired BAT function, resulting in both BAT and white adipose hypertrophy.	Oxygen	95-101	retinol dehydrogenase 1 (all trans)	Mus musculus	0-4
32756411-3	2020	Purified exogenous Tat-CRIP1a was penetrated into HT22 cells in a time and concentration-dependent manner and prevented H2O2-induced reactive oxygen species formation, DNA fragmentation, and cell damage.	Oxygen	142-148	tyrosine aminotransferase	Mus musculus	19-22
31781156-13	2019	Yet, sdha-2 and nduf2-2 expression is increased in the early embryo and in dauer larvae, stages where there is low oxygen tension.	Oxygen	115-121	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Caenorhabditis elegans	5-11
32848814-11	2020	Our results indicate facilitated peripheral blood supply and higher oxygen exploitation leading to activation of the energy sensor AMPK and differential regulation of angiogenic factors involved in muscle tissue remodeling and capillary growth.	Oxygen	68-74	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	131-135
31601767-2	2019	Here, we report a direct electrosynthesis strategy that delivers separate hydrogen (H2) and oxygen (O2) streams to an anode and cathode separated by a porous solid electrolyte, wherein the electrochemically generated H+ and HO2 - recombine to form pure aqueous H2O2 solutions.	Oxygen	92-98	heme oxygenase 2	Homo sapiens	224-227
31601767-2	2019	Here, we report a direct electrosynthesis strategy that delivers separate hydrogen (H2) and oxygen (O2) streams to an anode and cathode separated by a porous solid electrolyte, wherein the electrochemically generated H+ and HO2 - recombine to form pure aqueous H2O2 solutions.	Oxygen	100-102	heme oxygenase 2	Homo sapiens	224-227
30773606-2	2019	To the best of our knowledge, no investigation has systematically examined the expression changes of microRNA (miR)-449a and Amphiregulin (AREG) as well as their biological relationship during middle cerebral artery occlusion (MCAO) and oxygen and glucose deprivation/reperfusion (OGD/R).	Oxygen	237-243	microRNA 449a	Rattus norvegicus	101-120
31067022-2	2019	Herein, we report the structural dependence of the Ce1- xFe xO2-delta catalysts for CH4 combustion and CO oxidation via changing lattice distortion degrees, surface Fe2O3 states, and oxygen vacancy concentrations.	Oxygen	183-189	carboxylesterase 1	Homo sapiens	51-54
31687082-9	2019	AL-1 decreased lipopolysaccharide-induced generation of reactive oxygen species and nitric oxide in cultured macrophages in vitro; it also reversed the altered expression of inflammatory cytokines.	Oxygen	65-71	ephrin A5	Mus musculus	0-4
32751236-4	2020	The oxygen concentration was measured through the fluorescence quenching effect of an oxygen-sensitive fluorescent dye like platinum meso-tetra (pentafluorophenyl) porphyrin (PtP) by oxygen molecules.	Oxygen	4-10	protein tyrosine phosphatase receptor type U	Homo sapiens	175-178
31135464-10	2019	Hyperbaric oxygen reduced the inflammatory reaction and glial scar formation by inhibiting inflammation-related factors iNOS and COX-2 and glial scar-related components GFAP and NG2.	Oxygen	11-17	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	129-134
32751236-4	2020	The oxygen concentration was measured through the fluorescence quenching effect of an oxygen-sensitive fluorescent dye like platinum meso-tetra (pentafluorophenyl) porphyrin (PtP) by oxygen molecules.	Oxygen	86-92	protein tyrosine phosphatase receptor type U	Homo sapiens	175-178
30583924-12	2019	The mPAP-CO slope in patients correlated inversely with peak oxygen uptake (R = -0.41 and - 0.45, p = 0.036 and 0.022, baseline and follow-up, respectively).	Oxygen	61-67	phospholipid phosphatase 1	Mus musculus	4-8
32751236-4	2020	The oxygen concentration was measured through the fluorescence quenching effect of an oxygen-sensitive fluorescent dye like platinum meso-tetra (pentafluorophenyl) porphyrin (PtP) by oxygen molecules.	Oxygen	86-92	protein tyrosine phosphatase receptor type U	Homo sapiens	175-178
32661250-6	2020	We discover that Slc44a2 mediates choline transport into mitochondria, where choline metabolism leads to an increase in mitochondrial oxygen consumption and ATP production.	Oxygen	134-140	solute carrier family 44, member 2	Mus musculus	17-24
31555388-6	2019	Western blotting, reverse transcription-quantitative PCR (RT-qPCR) analysis, immunofluorescence and immunohistochemistry were used to evaluate the expression of CDK1 in pathological angiogenesis using an oxygen-induced retinopathy (OIR) mouse model.	Oxygen	204-210	cyclin-dependent kinase 1	Mus musculus	161-165
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hemoglobin beta, subunit rho	Gallus gallus	134-138
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	Oxygen	27-33	interferon alpha 2	Homo sapiens	225-242
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hemoglobin subunit alpha 1	Gallus gallus	229-233
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hemoglobin beta, subunit rho	Gallus gallus	235-239
31632347-7	2019	Next, Nodal was also shown to activate HIF1alpha and in vitro culture of mid CL explants under decreased oxygen level promoted Nodal expression and SMAD family member 3 (Smad3) phosphorylation.	Oxygen	105-111	nodal growth differentiation factor	Equus caballus	6-11
31632347-7	2019	Next, Nodal was also shown to activate HIF1alpha and in vitro culture of mid CL explants under decreased oxygen level promoted Nodal expression and SMAD family member 3 (Smad3) phosphorylation.	Oxygen	105-111	nodal growth differentiation factor	Equus caballus	127-132
31261295-1	2019	OBJECTIVES: The aim of this study was to noninvasively evaluate changes in renal stiffness, diffusion, and oxygenation in patients with chronic, advanced stage immunoglobulin A nephropathy (IgAN) by multiparametric magnetic resonance imaging using tomoelastography, diffusion-weighted imaging (DWI), and blood oxygen level-dependent (BOLD) imaging.	Oxygen	107-113	IGAN1	Homo sapiens	190-194
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	Oxygen	68-74	interferon alpha 2	Homo sapiens	225-242
31451430-5	2019	We analyzed body weight, adiposity, glucose homeostasis, insulin and lipid tolerance, energy expenditure, food intake, body temperature, and iBAT oxygen consumption ex vivo.	Oxygen	146-152	solute carrier family 10, member 2	Mus musculus	141-145
32037523-6	2020	Subsequent mechanistic studies demonstrated PHGDH decreased reactive oxygen species (ROS) through increasing reduced glutathione (GSH) synthesis, thereby promoting cell growth and BTZ resistance in MM cells.	Oxygen	69-75	phosphoglycerate dehydrogenase	Homo sapiens	44-49
31568497-0	2019	Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis.	Oxygen	64-70	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-20
31791154-0	2020	Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signaling.	Oxygen	58-64	stomatin like 2	Homo sapiens	0-23
31551408-8	2019	PM2.5-induced senescence involved aryl hydrocarbon receptor (AhR)-induced reactive oxygen species (ROS) production.	Oxygen	83-89	aryl hydrocarbon receptor	Homo sapiens	34-59
31551408-8	2019	PM2.5-induced senescence involved aryl hydrocarbon receptor (AhR)-induced reactive oxygen species (ROS) production.	Oxygen	83-89	aryl hydrocarbon receptor	Homo sapiens	61-64
31791154-0	2020	Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signaling.	Oxygen	58-64	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	129-133
31791154-3	2020	In the present study, we investigated the role of SLP-2 in regulating oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress, which has been used as an in vitro model of cerebral ischemia/reperfusion injury.	Oxygen	70-76	stomatin like 2	Homo sapiens	50-55
31791154-5	2020	Functional experiments demonstrated that SLP-2 overexpression significantly increased cell viability and decreased cell apoptosis and reactive oxygen species (ROS) production in OGD/R-exposed neurons, while SLP-2 inhibition showed the opposite effect.	Oxygen	143-149	stomatin like 2	Homo sapiens	41-46
31492813-1	2019	The mTORC1 pathway regulates cell growth and proliferation by properly coupling critical processes such as gene expression, protein translation, and metabolism to the availability of growth factors and hormones, nutrients, cellular energetics, oxygen status, and cell stress.	Oxygen	244-250	CREB regulated transcription coactivator 1	Mus musculus	4-10
32017160-5	2020	This is true for the "classical" hepatic nuclear receptors, including the aryl hydrocarbon receptor, or the constitutive androstane receptor; and also for some lesser-explored receptors such as peroxisome proliferator-activated receptors alpha and gamma; Mas-related G protein-coupled receptor; or other signaling molecules including fatty acid binding protein 1, apolipoprotein D, or reactive oxygen species.	Oxygen	394-400	aryl hydrocarbon receptor	Homo sapiens	74-99
32468046-0	2020	Excessive production of mitochondrion-derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3/SOD2 pathway.	Oxygen	55-61	superoxide dismutase 2	Homo sapiens	155-159
31546635-10	2019	HIF-1alpha, VEGF-A, iNOS, and NOX2-derived reactive oxygen species appear to be involved in the pathophysiology.	Oxygen	52-58	cytochrome b-245 heavy chain	Sus scrofa	30-34
32436952-12	2020	GO, KEGG and PPI-network analyses disclosed DEGs were significantly enriched in leukocyte migration, response to lipopolysaccharide, NIK/NF-kappaB signaling, response to reactive oxygen species, response to heat, and the hub genes were Tnf, Il1b, Cxcl2, Ccl2, Mmp9, Timp1, Hmox1, Serpine1, Mmp8 and Csf1, most of which were closely related to inflammagenesis and oxidative stress.	Oxygen	179-185	delta(4)-desaturase, sphingolipid 1	Rattus norvegicus	44-48
31607868-7	2019	Besides, the data also represented that 250 mg/Kg AA or SVCT2 overexpression facilitated NSPCs migration via promoting F-actin assembling in the manner of up-regulating CDC42 expression using oxygen-glucose deprivation in vitro.	Oxygen	192-206	solute carrier family 23 member 2	Homo sapiens	56-61
31607868-7	2019	Besides, the data also represented that 250 mg/Kg AA or SVCT2 overexpression facilitated NSPCs migration via promoting F-actin assembling in the manner of up-regulating CDC42 expression using oxygen-glucose deprivation in vitro.	Oxygen	192-206	cell division cycle 42	Homo sapiens	169-174
31547228-5	2019	This mechanism, based on ER chaperones like calnexin and ER oxidoreductases like Ero1alpha, controls reactive oxygen production within the ER, which can chemically modify the proteins controlling ER-mitochondria tethering, or mitochondrial membrane dynamics.	Oxygen	110-116	calnexin	Homo sapiens	44-52
32695469-2	2020	The compound contains a carb-oxy-lic acid group, a meth-oxy group and a tri-fluoro-methyl substituent on an asymmetric benzylic carbon atom.	Oxygen	29-32	syntaxin 8	Homo sapiens	24-28
31432816-3	2019	In this work, a new nano-MOF material using Mn(ii) as the active center can catalytically decompose high concentrations of H2O2 in tumor cells to generate O2, thereby improving the PDT efficacy in hypoxic tumors.	Oxygen	125-127	lysine acetyltransferase 8	Homo sapiens	25-28
32432255-2	2020	The as-synthesized unique FeCo/SWCNT catalyst exhibits remarkable oxygen electrocatalysis performance, especially oxygen evolution reaction activity and superior stability owing to the efficient synergistic effect between FeCo alloy and single-layer carbon regarding the electronic interaction and surface protection, achieving an overpotential (eta) of 253 mV at 10 mA cm-2 and a Tafel slope of 44 mV dec-1 in 1.0 M KOH solution while presenting outstanding stability after being tested for 50 hours.	Oxygen	66-72	deleted in esophageal cancer 1	Homo sapiens	402-407
31441297-1	2019	The end-on oxygen-bound sulfur monoxide (SO) complex of titanium oxyfluoride [OTiF2(eta1-OS)] was prepared via the isomerization of a bidentate sulfur dioxide complex of titanium difluoride [TiF2(O2S)] under UV-vis irradiation in cryogenic matrixes.	Oxygen	11-17	nuclear receptor coactivator 2	Homo sapiens	79-83
31441297-4	2019	It is more stable than the sulfur-bound OTiF2(eta1-SO) isomers by about 15.0 kcal/mol but less stable than the TiF2(O2S) precursor by 14.4 kcal/mol at the B3LYP level.	Oxygen	116-119	nuclear receptor coactivator 2	Homo sapiens	41-45
31441297-5	2019	The formation of OTiF2(eta1-OS) involves cleavage of the S-O bond of TiF2(O2S) with an energy barrier of 25.6 kcal/mol.	Oxygen	74-77	nuclear receptor coactivator 2	Homo sapiens	18-22
31211432-0	2019	How we diagnose and manage altered oxygen affinity hemoglobin variants: Lest we forget JAK2 Exon 12 mutation.	Oxygen	35-41	Janus kinase 2	Homo sapiens	87-91
32575773-2	2020	Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced neuroprotection following oxygen and glucose deprivation (OGD) in mouse cortical neurons.	Oxygen	285-291	hypocretin	Mus musculus	151-155
31131557-12	2019	The overexpression of GS, GCK, CYP1A, and HIFalpha proteins were observed downstream in the oxygen-poor area.	Oxygen	92-98	glucokinase	Rattus norvegicus	26-29
32325601-3	2020	In addition to sulfide, the complete conversion of Ag NPs to Ag2S will require dissolved oxygen or some other oxidant so dispersed metal sulfides may be an important pool of reactive sulfide for such reactions in oxygenated systems.	Oxygen	89-95	angiotensin II receptor type 1	Homo sapiens	61-65
31299317-2	2019	The unstable hemoglobin variant, hemoglobin Sendagi, is characterized by decreased oxygen affinity caused by replacement of one of the critical amino acid residues, phenylalanine beta 42 (CD1) of the beta-chain, with valine in the heme pocket, resulting in methemoglobin formation.	Oxygen	83-89	CD1c molecule	Homo sapiens	188-191
32518264-9	2020	Pathological pre-retinal neovessels of oxygen-induced retinopathy (OIR) mice were attenuated in PN knock-out, TNC knock-out and dual knock-out mice compared to wild-type mice.	Oxygen	39-45	tenascin C	Mus musculus	110-113
30961716-1	2019	In this paper, the effect of channel annealing and oxygen flow rate in P-type tin-monoxide (SnO) thin film transistor (TFT) was investigated to reach the process compatibility with n-type oxide-based TFT.	Oxygen	51-57	strawberry notch homolog 1	Homo sapiens	92-95
30961716-4	2019	Besides, the higher oxygen flow rate was also helpful for improving device mobility and driving current, but shows a slight increase in off-state leakage, which is unavoidable due to the increase of grain in SnO channel.	Oxygen	20-26	strawberry notch homolog 1	Homo sapiens	208-211
32577378-1	2020	We report wide-field polygon-scanning functional OR-PAM that for the first time achieves 1-MHz A-line rate of oxygen saturation in vivo.	Oxygen	110-116	peptidylglycine alpha-amidating monooxygenase	Mus musculus	52-55
31286450-0	2019	Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity.	Oxygen	24-30	peroxiredoxin 6	Mus musculus	51-66
32512511-0	2020	Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.	Oxygen	4-10	RAB20, member RAS oncogene family	Homo sapiens	52-57
31311719-7	2019	Overexpression of ATGL-1 increases basal and maximal oxygen consumption rate and extends lifespan in C. elegans.	Oxygen	53-59	PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1	Caenorhabditis elegans	18-24
31578733-4	2020	Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs.	Oxygen	245-251	xanthine dehydrogenase	Homo sapiens	17-20
31146014-0	2019	Hyperbaric oxygen inhibits the HMGB1/RAGE signaling pathway by upregulating Mir-107 expression in human osteoarthritic chondrocytes.	Oxygen	11-17	high mobility group box 1	Homo sapiens	31-36
31146014-0	2019	Hyperbaric oxygen inhibits the HMGB1/RAGE signaling pathway by upregulating Mir-107 expression in human osteoarthritic chondrocytes.	Oxygen	11-17	microRNA 107	Homo sapiens	76-83
31146014-2	2019	We investigated mir-107/HMGB-1 signaling in OA after hyperbaric oxygen (HBO) treatment.	Oxygen	64-70	microRNA 107	Homo sapiens	16-23
32390233-4	2020	The oxygen-deficient Fe-Co-O nanosheets (3-4 nm thickness) display an overpotential of 260 mV@10 mA cm-2 and a Tafel slope of 53 mV dec-1 , outperforming those of the benchmark RuO2 in 1.0 m KOH.	Oxygen	4-10	deleted in esophageal cancer 1	Homo sapiens	132-137
31208720-4	2019	In this study, neonatal mice were exposed to 75% oxygen from postnatal day (P)7 to P12 to induce vaso-obliteration, and then returned to room air from P12 to P17, causing the retina to become hypoxic and inducing vascular endothelial growth factor (VEGF) signaling, which produces pathological neovascularization.	Oxygen	49-55	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	83-86
30370524-5	2019	We observed that miR-125a-5p can inhibit tet methylcytosine dioxygenase 2 (TET2) expression at the posttranscription level, resulting in abnormal DNA methylation, mitochondrial dysfunction, and increased reactive oxygen species production, activated nuclear factor-kappaB that induces activation of inflammasome and maturation, release of proinflammatory cytokines interleukin (IL)-1beta and IL-18, and pyroptosis.	Oxygen	62-68	tet methylcytosine dioxygenase 2	Homo sapiens	75-79
32416225-7	2020	Using alkoxyresorufin molecules as substrates, the Vmax/Km ratios for resorufin production decreased from 426 to 393 for CYP1A1 and from 343 to 202 for CYP2B1 at a low oxygen concentration (4.1 ppm) compared to the ratios observed at a normal oxygen concentration (6.5 ppm).	Oxygen	168-174	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	152-158
30772534-0	2019	One-pot aqueous synthesis of two-dimensional porous bimetallic PtPd alloyed nanosheets as highly active and durable electrocatalyst for boosting oxygen reduction and hydrogen evolution.	Oxygen	145-151	protein tyrosine phosphatase receptor type D	Homo sapiens	63-67
30772534-4	2019	The PtPd NSs exhibited excellent oxygen reduction reaction (ORR) activity with the positive shift (c.a.	Oxygen	33-39	protein tyrosine phosphatase receptor type D	Homo sapiens	4-8
31073082-0	2019	Higher alveolar nitric oxide in COPD is related to poorer physical capacity and lower oxygen saturation after physical testing.	Oxygen	86-92	COPD	Homo sapiens	32-36
31242045-0	2019	Adenosine A1 receptor-mediated protection of mouse hippocampal synaptic transmission against oxygen and/or glucose deprivation: a comparative study.	Oxygen	93-99	adenosine A1 receptor	Mus musculus	0-21
32030866-2	2020	Here, we design a three-in-one surface treatment via the pyrolysis of urea to improve the voltage and capacity stability of Li1.2Mn0.6Ni0.2O2 (LMNO), by which oxygen vacancy, spinel phase integration and N-doped carbon nanolayer are synchronously built on the surface of LMNO microspheres.	Oxygen	159-165	transglutaminase 1	Homo sapiens	124-127
31242045-8	2019	These studies quantify the neuroprotective role of the adenosine A1 receptor during a variety of metabolic stresses within the same recording system.NEW & NOTEWORTHY Deprivation of oxygen and/or glucose causes a rapid adenosine A1 receptor-mediated decrease in synaptic transmission in mouse hippocampus.	Oxygen	181-187	adenosine A1 receptor	Mus musculus	55-76
31306398-7	2019	Higher levels of CHI3L1 were associated with higher composite clinical severity scores and predicted prolonged time to resolution of tachypnea and tachycardia, time to wean oxygen and time to sit.	Oxygen	173-179	chitinase 3 like 1	Homo sapiens	17-23
31075813-4	2019	The most recent versions have concentrated on presenting an algorithm for COPD management based on 7 severity domains: spirometry, symptoms, exacerbations, oxygen requirements, the presence of chronic bronchitis or emphysema and comorbidities.	Oxygen	156-162	COPD	Homo sapiens	74-78
30869870-4	2019	This article describes a new electrostatic reagent ion switching, ERIS, technique by which H3O+, NO+, and O2+  reagent ions, produced simultaneously in three separate gas discharges, can be purified in post-discharge source drift tubes, switched rapidly, and selected for transport into a flow-drift tube reactor.	Oxygen	106-109	stimulator of interferon response cGAMP interactor 1	Homo sapiens	66-70
30869870-6	2019	The speed and sensitivity of ERIS coupled to a selected ion flow-drift tube mass spectrometry, SIFDT-MS, is demonstrated by the simultaneous quantification of methanol with H3O+, acetone with NO+, and dimethyl sulfide with O2+  reagent ions in single breath exhalations.	Oxygen	223-226	stimulator of interferon response cGAMP interactor 1	Homo sapiens	29-33
30876876-5	2019	Commensal-IgG immune complexes engaged gut-resident FcgammaR-expressing macrophages, inducing NLRP3- and reactive-oxygen-species-dependent production of interleukin-1beta (IL-1beta) and neutrophil-recruiting chemokines.	Oxygen	114-120	immunoglobulin heavy variable V1-62	Mus musculus	10-13
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	pre T cell antigen receptor alpha	Homo sapiens	145-148
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	pre T cell antigen receptor alpha	Homo sapiens	145-148
31337753-0	2019	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1alpha and HIF2alpha.	Oxygen	22-28	von Hippel-Lindau tumor suppressor	Homo sapiens	72-75
32162740-4	2020	Further, in response to low oxygen, first trimester chorionic villous tissue from pregnancies at increased risk of developing preeclampsia secreted significantly more STC-1 than normal tissue under the same conditions.	Oxygen	28-34	stanniocalcin 1	Homo sapiens	167-172
31215575-3	2019	In this study, we presented the synthesis of a Co-containing metal-organic framework (Co-MOF) and explored its electrocatalytic application towards the oxygen electrocatalysis (i.e. the oxygen reduction reaction and oxygen evolution reaction).	Oxygen	186-192	lysine acetyltransferase 8	Homo sapiens	89-92
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	36-38	nuclear factor of activated T cells 5	Homo sapiens	93-98
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	pre T cell antigen receptor alpha	Homo sapiens	145-148
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	pre T cell antigen receptor alpha	Homo sapiens	145-148
30971109-3	2021	The objective of this study was to investigate whether preconditioning with hypoxia and/or transforming growth factor-beta 3 (TGF-beta3) can enhance MSC survival and extracellular matrix production in a low oxygen and nutrient-limited microenvironment.	Oxygen	207-213	transforming growth factor beta 3	Homo sapiens	91-124
30971109-3	2021	The objective of this study was to investigate whether preconditioning with hypoxia and/or transforming growth factor-beta 3 (TGF-beta3) can enhance MSC survival and extracellular matrix production in a low oxygen and nutrient-limited microenvironment.	Oxygen	207-213	transforming growth factor beta 3	Homo sapiens	126-135
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	nuclear factor of activated T cells 5	Homo sapiens	93-98
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	aquaporin 1	Mus musculus	258-269
32162740-7	2020	As both low oxygen and cAMP are known to play a central role in placental function, their regulation of STC-1 points to a potentially important role in the maintenance of a normal healthy pregnancy and we would hypothesize that it may act to protect against prolonged placental hypoxia seen in preeclampsia.	Oxygen	12-18	stanniocalcin 1	Homo sapiens	104-109
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	aquaporin 1	Mus musculus	271-276
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	solute carrier family 14 (urea transporter), member 1	Mus musculus	283-301
32323755-3	2020	AMPK indirectly inhibits mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a serine/threonine kinase and central regulator of cell growth and metabolism, which integrates various growth inhibitory signals, such as the depletion of glucose, amino acids, ATP and oxygen.	Oxygen	268-274	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	solute carrier family 14 (urea transporter), member 1	Mus musculus	303-308
31067085-11	2019	This work provides novel and relevant information about the signaling pathway of NFAT5 during responses to oxygen depletion in mammalian cells and suggests that the expression of iNOS induced by hypoxia is dependent on NFAT5.	Oxygen	107-113	nuclear factor of activated T cells 5	Homo sapiens	81-86
31067085-11	2019	This work provides novel and relevant information about the signaling pathway of NFAT5 during responses to oxygen depletion in mammalian cells and suggests that the expression of iNOS induced by hypoxia is dependent on NFAT5.	Oxygen	107-113	nuclear factor of activated T cells 5	Homo sapiens	219-224
31022415-7	2019	In contrast, high HNF-1beta expression was significantly associated with SLC3A1 expression, which plays a major role in HNF-1beta-triggered induction of reactive oxygen species in OCCCas, independent of abnormalities in both beta-catenin and MSI/MMR status.	Oxygen	162-168	solute carrier family 3 member 1	Homo sapiens	73-79
30979899-4	2019	With 0.45 wt.% ruthenium loading, the catalyst exhibits outstanding activity with overpotential 198 mV at the current density of 10 mA cm-2 and a small Tafel slope of 39 mV dec-1 for oxygen evolution reaction.	Oxygen	183-189	deleted in esophageal cancer 1	Homo sapiens	173-178
30964448-6	2019	Physiologic assessment of these activated MEK1-ERK1/2 mice showed enhanced metabolic activity and oxygen consumption with greater muscle fatigue resistance.	Oxygen	98-104	mitogen-activated protein kinase kinase 1	Mus musculus	42-46
30964448-6	2019	Physiologic assessment of these activated MEK1-ERK1/2 mice showed enhanced metabolic activity and oxygen consumption with greater muscle fatigue resistance.	Oxygen	98-104	mitogen-activated protein kinase 3	Mus musculus	47-53
32323755-3	2020	AMPK indirectly inhibits mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a serine/threonine kinase and central regulator of cell growth and metabolism, which integrates various growth inhibitory signals, such as the depletion of glucose, amino acids, ATP and oxygen.	Oxygen	268-274	CREB regulated transcription coactivator 1	Mus musculus	73-79
30827111-3	2019	More stable and C1-product-selective SnO x/AgO x catalysts were obtained by electrodepositing Sn on O2-plasma-pretreated Ag surfaces.	Oxygen	100-102	strawberry notch homolog 1	Homo sapiens	37-40
31218852-1	2019	The mitochondrial alternative oxidase, AOX, present in most eukaryotes apart from vertebrates and insects, catalyzes the direct oxidation of ubiquinol by oxygen, by-passing the terminal proton-motive steps of the respiratory chain.	Oxygen	154-160	Aldox89A	Drosophila melanogaster	39-42
32165497-0	2020	X-ray structures of catalytic intermediates of cytochrome c oxidase provide insights into its O2 activation and unidirectional proton-pump mechanisms.	Oxygen	94-96	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	47-67
30597572-4	2019	Interestingly, we found that the interaction of BIN2 and BES1 was oxygen-dependent, and oxygen can directly modify BIN2.	Oxygen	66-72	Protein kinase superfamily protein	Arabidopsis thaliana	48-52
30597572-4	2019	Interestingly, we found that the interaction of BIN2 and BES1 was oxygen-dependent, and oxygen can directly modify BIN2.	Oxygen	66-72	Protein kinase superfamily protein	Arabidopsis thaliana	115-119
30770985-10	2019	Additionally, Sestrin2 was positively correlated with apnea/hypopnea index (AHI), oxygen desaturation index, oxygen saturation &lt; 90% percentage of recording time spent (PRTS) and high-density lipoprotein (HDL), while negatively correlated with the lowest oxygen saturation.	Oxygen	82-88	sestrin 2	Homo sapiens	14-22
30770985-10	2019	Additionally, Sestrin2 was positively correlated with apnea/hypopnea index (AHI), oxygen desaturation index, oxygen saturation &lt; 90% percentage of recording time spent (PRTS) and high-density lipoprotein (HDL), while negatively correlated with the lowest oxygen saturation.	Oxygen	109-115	sestrin 2	Homo sapiens	14-22
30770985-11	2019	Importantly, Sestrin2 was independently associated with AHI, oxygen saturation &lt; 90% PRTS and HDL.	Oxygen	61-67	sestrin 2	Homo sapiens	13-21
30597572-4	2019	Interestingly, we found that the interaction of BIN2 and BES1 was oxygen-dependent, and oxygen can directly modify BIN2.	Oxygen	88-94	Protein kinase superfamily protein	Arabidopsis thaliana	48-52
32165497-1	2020	Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process.	Oxygen	35-37	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
30597572-4	2019	Interestingly, we found that the interaction of BIN2 and BES1 was oxygen-dependent, and oxygen can directly modify BIN2.	Oxygen	88-94	Protein kinase superfamily protein	Arabidopsis thaliana	115-119
32165497-1	2020	Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process.	Oxygen	35-37	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Oxygen	21-23	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
30850878-7	2019	Peak oxygen uptake (peak VO2) was reduced in mR3 and mR4 compared to mR1 and mR2.	Oxygen	5-11	eosinophil-associated, ribonuclease A family, member 3	Mus musculus	45-48
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Oxygen	184-186	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
30850878-7	2019	Peak oxygen uptake (peak VO2) was reduced in mR3 and mR4 compared to mR1 and mR2.	Oxygen	5-11	eosinophil-associated, ribonuclease A family, member 4	Mus musculus	53-56
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Oxygen	184-186	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
32271890-1	2020	Purpose: Purpose The role of endothelial Yes-associated protein 1 (YAP) in the pathogenesis of retinal angiogenesis and the astrocyte network in the mouse oxygen-induced retinopathy (OIR) model is unknown.	Oxygen	155-161	yes-associated protein 1	Mus musculus	41-65
31353872-4	2019	Usp2KO cells reduced the accumulation of intracellular adenosine triphosphate (ATP) content and oxygen consumption.	Oxygen	96-102	ubiquitin specific peptidase 2	Mus musculus	0-4
32271890-1	2020	Purpose: Purpose The role of endothelial Yes-associated protein 1 (YAP) in the pathogenesis of retinal angiogenesis and the astrocyte network in the mouse oxygen-induced retinopathy (OIR) model is unknown.	Oxygen	155-161	yes-associated protein 1	Mus musculus	67-70
30710412-8	2019	RESULTS: The expression of HIF-1alpha and mitochondrial NDUFA4L2 increased in NSCLC cell lines cultured in hypoxic conditions (1% O2 ).	Oxygen	130-132	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	56-64
32245432-0	2020	Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation.	Oxygen	104-110	ANI_1_820034	Aspergillus niger CBS 513.88	53-65
30785159-1	2019	We prepare the lithium-rich layered oxide Li1.2Mn0.54Co0.13Ni0.13O2 with a 3.65 V average-discharge voltage by using lithiated homologous spinel Li0.4Mn0.54Ni0.13Co0.13O1.6 in an O2 atmosphere.	Oxygen	65-67	transglutaminase 1	Homo sapiens	42-45
30243821-9	2019	Nevertheless, in general outcomes are consistent with the original hypothesis, that the role of AMPK has evolved, through natural selection, to extend to the regulation of breathing, and thus oxygen and energy (ATP) supply to the whole body.	Oxygen	192-198	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	96-100
30932749-11	2019	Concomitantly, it enhances the scavenger of reactive oxygen species (SOD-2) to maintain moderate levels of oxidative stress.	Oxygen	53-59	superoxide dismutase 2	Homo sapiens	69-74
31020771-3	2019	In 1 m KOH solution, the optimized NCF catalysts show a low overpotential of 230 mV for the oxygen evolution reaction (OER) at a current density of 10 mA cm-2 with a low Tafel slope of 34.3 mV dec-1 , indicating fast and efficient OER kinetics.	Oxygen	92-98	deleted in esophageal cancer 1	Homo sapiens	193-198
30876351-14	2019	A new aerobic reaction cycle is hypothesized, wherein dissolved dioxygen captures radiolytic H  or eaq -, enters HO2  /O2  -, reductively quenches cysteine thiyl radicals, and cycles back to O2.	Oxygen	64-72	heme oxygenase 2	Homo sapiens	113-116
30876351-14	2019	A new aerobic reaction cycle is hypothesized, wherein dissolved dioxygen captures radiolytic H  or eaq -, enters HO2  /O2  -, reductively quenches cysteine thiyl radicals, and cycles back to O2.	Oxygen	119-121	heme oxygenase 2	Homo sapiens	113-116
32171979-7	2020	The NSAPP pathway is an oxide transport chain that begins when insulin stimulates NADPH oxidase-4 to generate superoxide (O2 -).	Oxygen	122-126	NADPH oxidase 4	Homo sapiens	82-97
30857203-1	2019	APETALA2/ethylene-responsive factor superfamily (AP2/ERF) is a transcription factor involved in abiotic stresses, for instance, cold, drought, and low oxygen.	Oxygen	151-157	ethylene-responsive transcription factor RAP2-3-like	Nicotiana tabacum	49-52
31217464-3	2019	Here, we present the first in situ carbon and oxygen isotope data of texturally distinct calcite in calc-silicate xenoliths from arc volcanics in a case study from Merapi volcano (Indonesia).	Oxygen	46-52	mitochondrial calcium uptake 1	Homo sapiens	89-93
32171979-8	2020	NADPH oxidase-4 forms a novel, tight complex with superoxide dismutase-3, to efficiently transfer O2 - for quantitative conversion into hydrogen peroxide.	Oxygen	98-100	NADPH oxidase 4	Homo sapiens	0-15
32150490-0	2020	Astrocyte-derived exosomes transfer miR-190b to inhibit oxygen and glucose deprivation-induced autophagy and neuronal apoptosis.	Oxygen	56-62	microRNA 190b	Mus musculus	36-44
31588297-6	2019	Compared with the commercially available methylene blue (MB), syn-5al exhibits a better ability (Phi Delta = 0.61) to sensitize singlet oxygen (1O2) when irradiated with a 680 nm laser beam, and has potential as a photodynamic therapy (PDT) photosensitizer in the body"s therapeutic window (650-900 nm).	Oxygen	136-142	syntrophin gamma 2	Homo sapiens	62-67
30866429-7	2019	Further, the SnO nanoshells have higher oxygen vacancy densities compared with other metal oxide ammonia sensing materials, enabling it to have higher performance.	Oxygen	40-46	strawberry notch homolog 1	Homo sapiens	13-16
32183538-0	2020	COPD Patients" Experience of Long-Term Domestic Oxygen-Enriched Nasal High Flow Treatment: A Qualitative Study.	Oxygen	48-54	COPD	Homo sapiens	0-4
30659730-1	2019	The high-valence iron species (Fe(IV)=O) in the cytochrome P450 enzyme superfamily is generated via the activation of O2 , and serves as the active center of selective hydrocarbon oxidation reactions.	Oxygen	118-120	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	59-63
30659730-2	2019	Furthermore, P450 can employ an alternate route to produce Fe(IV)=O, even from H2 O2 without O2 activation.	Oxygen	82-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	13-17
30950579-11	2019	The characteristic time constant of the mass transport of water and hydroxide ions across the liquid phase within the ODC is determined to be tau  mt ,  H  2 O    0.176 s, whereas the time constant of oxygen mass transport into the reaction zone is several magnitudes smaller: tau  mt ,  O  2     1.70x10-6  s. Finally, a sensitivity analysis confirms that the overall performance is best improved by adjusting mass transport properties in the liquid phase.	Oxygen	201-207	ornithine decarboxylase 1	Homo sapiens	118-121
31532699-14	2020	The combination of supplemental oxygen, BAC formulation, and high-irradiance UV-A resulted in the largest biomechanical changes and most pronounced flattening effects of the three epi-on protocols.	Oxygen	32-38	tissue factor pathway inhibitor	Homo sapiens	180-183
30223723-7	2019	Interestingly, when BeWo-immortalized placental trophoblast cells were cultured in oxygen concentrations mimicking healthy and ischemic placentas, there was a significant increase in acetylated at K9, K18, K27, and K56.	Oxygen	83-89	keratin 27	Homo sapiens	206-209
30053508-11	2019	In addition, HIF-2alpha translation is controlled by iron regulatory protein (IRP) activity, providing another level of interdependence between iron and oxygen homeostasis.	Oxygen	153-159	Wnt family member 2	Homo sapiens	53-76
30053508-11	2019	In addition, HIF-2alpha translation is controlled by iron regulatory protein (IRP) activity, providing another level of interdependence between iron and oxygen homeostasis.	Oxygen	153-159	Wnt family member 2	Homo sapiens	78-81
32147400-4	2020	We found that the expression of Bv8 was significantly increased in two different models of retinal neovascularization: the oxygen-induced retinopathy (OIR) mouse model and the rhodopsin promoter (rho)/VEGF transgenic mouse model.	Oxygen	123-129	prokineticin 2	Mus musculus	32-35
29232010-0	2019	Protective effect of HSP27 in atherosclerosis and coronary heart disease by inhibiting reactive oxygen species.	Oxygen	96-102	heat shock protein family B (small) member 2	Homo sapiens	21-26
31137489-5	2019	Molecular docking simulations of the prepared diamides within CA IX active site revealed the ability of 5h to establish an additional H-bond between the heterocyclic oxygen and HE/Gln67.	Oxygen	166-172	carbonic anhydrase 9	Homo sapiens	62-67
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Oxygen	47-49	Janus kinase 2	Homo sapiens	27-31
32014499-4	2020	DKK-1 was upregulated by Ang II, which was weakened by the Ang II type 1 receptor (AT1R) blocker, reactive oxygen species (ROS) scavenger, and p38 inhibitor.	Oxygen	107-113	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	0-5
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Oxygen	47-49	mutS homolog 2	Homo sapiens	84-88
30018312-4	2019	METHODS: The browning effect of alpha-MSH was determined in isolated adipocytes using the 3T3-L1 cell line and in inguinal subcutaneous adipose tissue (ingWAT) of diet-induced obese (DIO) mice by quantifying the expression of browning hallmark genes, oxygen consumption, and mitochondrial biogenesis.	Oxygen	251-257	pro-opiomelanocortin-alpha	Mus musculus	32-41
30624373-9	2019	Both groups had similar total ventilation and oxygen saturation (all P &gt; .05), but PLB resulted in higher mean oxygen uptake (13.9 +- 3.6 vs 12.9 +- 3.2 mL/kg/min, P = .02), even when corrected for walking distance (P &lt; .001).	Oxygen	114-120	phospholamban	Homo sapiens	86-89
31901420-8	2020	Firstly, activity decreases (blood oxygen level-dependent signal) during tremor-inducing postural holding in the primary sensorimotor cortex and cerebellar lobule VIII, and activity increases in the supplementary motor area and cerebellar lobule V during rest (p &lt;= 0.05, post hoc two-tailed t-test).	Oxygen	35-41	cytochrome c oxidase subunit 8A	Homo sapiens	163-167
30700584-2	2019	The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes that regulate adaptive responses to hypoxia through controlling the activity of HIF and NF-kappaB-dependent transcriptional pathways.	Oxygen	93-99	egl-9 family hypoxia inducible factor 2	Homo sapiens	25-88
30650008-9	2019	TTP overexpression reduced both the extracellular acidification rate (ECAR) and the oxygen consumption rate (OCR) of cancer cells.	Oxygen	84-90	ZFP36 ring finger protein	Homo sapiens	0-3
30802768-6	2019	The formed MoOCo further leads to a distribution of orientations of the electrons around the metal centers due to the different electronegativity of Mo and Co. During the reaction, the dissolved O2 is efficiently reduced to HO2/O2- around the electron-rich Mo center, and HO2/O2- is further reduced to H2O2 around the Co center.	Oxygen	195-197	heme oxygenase 2	Homo sapiens	224-227
30802768-6	2019	The formed MoOCo further leads to a distribution of orientations of the electrons around the metal centers due to the different electronegativity of Mo and Co. During the reaction, the dissolved O2 is efficiently reduced to HO2/O2- around the electron-rich Mo center, and HO2/O2- is further reduced to H2O2 around the Co center.	Oxygen	195-197	heme oxygenase 2	Homo sapiens	272-275
30802768-6	2019	The formed MoOCo further leads to a distribution of orientations of the electrons around the metal centers due to the different electronegativity of Mo and Co. During the reaction, the dissolved O2 is efficiently reduced to HO2/O2- around the electron-rich Mo center, and HO2/O2- is further reduced to H2O2 around the Co center.	Oxygen	225-227	heme oxygenase 2	Homo sapiens	272-275
30802768-6	2019	The formed MoOCo further leads to a distribution of orientations of the electrons around the metal centers due to the different electronegativity of Mo and Co. During the reaction, the dissolved O2 is efficiently reduced to HO2/O2- around the electron-rich Mo center, and HO2/O2- is further reduced to H2O2 around the Co center.	Oxygen	225-227	heme oxygenase 2	Homo sapiens	272-275
31035548-0	2019	Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands.	Oxygen	15-21	cannabinoid receptor 1 (brain)	Mus musculus	59-81
30920211-4	2019	Although the calculated adsorption energy of CO is exceedingly higher than N2O for our studied systems, the adsorbed CO could react with the surface oxygen atom of the PTA support through the MvK mechanism to form an oxygen vacancy on the PTA surface.	Oxygen	149-155	pre T cell antigen receptor alpha	Homo sapiens	168-171
30920211-4	2019	Although the calculated adsorption energy of CO is exceedingly higher than N2O for our studied systems, the adsorbed CO could react with the surface oxygen atom of the PTA support through the MvK mechanism to form an oxygen vacancy on the PTA surface.	Oxygen	149-155	pre T cell antigen receptor alpha	Homo sapiens	239-242
30814486-10	2019	TIGAR can decrease lactate production and accelerate oxygen consumption and ATP generation to maintain a high rate of OXPHOS in differentiated NSCs.	Oxygen	53-59	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
30920211-4	2019	Although the calculated adsorption energy of CO is exceedingly higher than N2O for our studied systems, the adsorbed CO could react with the surface oxygen atom of the PTA support through the MvK mechanism to form an oxygen vacancy on the PTA surface.	Oxygen	217-223	pre T cell antigen receptor alpha	Homo sapiens	168-171
32066880-3	2020	Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, in stromal cells elevates production of reactive oxygen species, triggers an inflammatory response including activation of IL-6, and promotes tumorigenesis in vitro and in vivo.	Oxygen	197-203	monoamine oxidase A	Mus musculus	35-54
30920211-4	2019	Although the calculated adsorption energy of CO is exceedingly higher than N2O for our studied systems, the adsorbed CO could react with the surface oxygen atom of the PTA support through the MvK mechanism to form an oxygen vacancy on the PTA surface.	Oxygen	217-223	pre T cell antigen receptor alpha	Homo sapiens	239-242
30920211-5	2019	N2O acts as an oxygen donor to replenish the PTA support and release N2 in the whole reaction process.	Oxygen	15-21	pre T cell antigen receptor alpha	Homo sapiens	45-48
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	programmed cell death 1	Homo sapiens	132-135
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	pre T cell antigen receptor alpha	Homo sapiens	136-139
30786006-6	2019	In addition, hexokinase 2 (HK2) protein degradation was considerably elevated in the presence of NK007, which resulted in the reduction of oxygen consumption rate and extracellular acidification rate.	Oxygen	139-145	hexokinase 2	Homo sapiens	13-25
30786006-6	2019	In addition, hexokinase 2 (HK2) protein degradation was considerably elevated in the presence of NK007, which resulted in the reduction of oxygen consumption rate and extracellular acidification rate.	Oxygen	139-145	hexokinase 2	Homo sapiens	27-30
32066880-3	2020	Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, in stromal cells elevates production of reactive oxygen species, triggers an inflammatory response including activation of IL-6, and promotes tumorigenesis in vitro and in vivo.	Oxygen	197-203	monoamine oxidase A	Mus musculus	56-60
32066881-9	2020	In contrast, the use of a BH4 peptide that disrupts the Bcl-xL/VDAC1 complex supports that Bcl-xL by acting on VDAC1 permeability contributes to cell migration through the promotion of reactive oxygen species production by the electron transport chain.	Oxygen	194-200	voltage dependent anion channel 1	Homo sapiens	63-68
30447561-8	2019	An increase in surface Ce3+ species and surface density of oxygen vacancies would benefit the adsorption and catalytic transformation of O3 which eventually form the reactive oxygen species over Mn-xCe/ZSM-5.	Oxygen	59-65	X chromosome inactivation center	Homo sapiens	198-201
30910834-4	2019	Our results show that the polymorphic for gene confers protection during low oxygen stress at the expense of longevity and a decline in locomotor activity with age in D. melanogaster, which suggests a novel role for the PKG pathway in healthy aging and senescence.	Oxygen	77-83	Protein kinase, cGMP-dependent at 21D	Drosophila melanogaster	220-223
32066881-9	2020	In contrast, the use of a BH4 peptide that disrupts the Bcl-xL/VDAC1 complex supports that Bcl-xL by acting on VDAC1 permeability contributes to cell migration through the promotion of reactive oxygen species production by the electron transport chain.	Oxygen	194-200	voltage dependent anion channel 1	Homo sapiens	111-116
31904482-5	2020	Furthermore, genetic or pharmacological inhibition of CPT2 with perhexiline disturbed NADPH and redox homeostasis and increased reactive oxygen species (ROS) generation and cell apoptosis in gastrointestinal cancer cells following oxaliplatin treatment.	Oxygen	137-143	carnitine palmitoyltransferase 2	Homo sapiens	54-58
30854842-6	2019	In solution, the excimer emission of Pd1 shows a much greater sensitivity toward oxygen than the monomer emission with a very large Stern-Volmer constant ( Ksv) that is more than twice that of the monomer emission.	Oxygen	81-87	programmed cell death 1	Homo sapiens	37-40
30854842-8	2019	Furthermore, Pd1 shows an excellent photostability, compared to the Pt(II) analogue, making it one of the best and highly robust oxygen sensors based on cyclometalated metal complexes.	Oxygen	129-135	programmed cell death 1	Homo sapiens	13-16
30667570-4	2019	As a proof-of-concept, the Fe-doped carbon electrocatalysts realized a Pt/C-like half-wave potential of 0.869 V vs. RHE and small Tafel slope of 51.3 mV dec-1 in oxygen reduction reaction.	Oxygen	162-168	deleted in esophageal cancer 1	Homo sapiens	153-158
30659148-5	2019	Among the findings are the observations that Chlamydomonas exhibits lower respiratory activity at night compared with the day; multiple fermentation pathways, some oxygen-sensitive, are expressed at night in aerated cultures; we propose that the ferredoxin, FDX9, is potentially the electron donor to hydrogenases.	Oxygen	164-170	uncharacterized protein	Chlamydomonas reinhardtii	246-256
30670706-8	2019	By controlling trophoblast ATP production, mTORC1 links nutrient and O2 availability and growth factor signaling to placental function and fetal growth.	Oxygen	69-71	CREB regulated transcription coactivator 1	Mus musculus	43-49
32296390-8	2020	Furthermore, by using the O2- scavenger MnTMPyP, we verified that altering Plin5 expression impacted lipotoxic cell death partially via modulating oxidative stress.	Oxygen	26-28	perilipin 5	Rattus norvegicus	75-80
30656220-9	2019	These results indicate that NOX2-induced oxidative stress accompanied by macrophage infiltration plays an important role in alteration of oxygen homeostasis in Aqp11 -/- mice.	Oxygen	138-144	cytochrome b-245, beta polypeptide	Mus musculus	28-32
30540181-5	2019	The transition-metal clusters enable highly efficient oxygen evolution through water electrolysis in alkaline media, manifested by an overpotential of 192 mV at 10 mA cm-2, a low Tafel slope of 36 mV dec-1, and long-term stability for 30 h of electrolysis.	Oxygen	54-60	deleted in esophageal cancer 1	Homo sapiens	200-205
30633921-4	2019	Scg3-neutralizing monoclonal antibody (mAb) was reported to alleviate pathological retinal neovascularization in oxygen-induced retinopathy mice and retinal vascular leakage in diabetic mice with high efficacy and disease selectivity.	Oxygen	113-119	secretogranin III	Mus musculus	0-4
30855350-0	2019	Hyperbaric oxygen improves functional recovery of rats after spinal cord injury via activating stromal cell-derived factor-1/CXC chemokine receptor 4 axis and promoting brain-derived neurothrophic factor expression.	Oxygen	11-17	C-X-C motif chemokine ligand 12	Rattus norvegicus	95-149
32096636-5	2020	Also, the products analysis for the reactions of VTFA and ATFA with Cl atoms in the presence of O2 were investigated using Gas Chromatography with Mass Spectrometer (GC-MS) and Gas Chromatography with Infrared spectroscopy (GC-IR).	Oxygen	96-98	activating transcription factor 7	Homo sapiens	58-62
30855350-2	2019	This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).	Oxygen	91-97	C-X-C motif chemokine ligand 12	Rattus norvegicus	169-198
30855350-2	2019	This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).	Oxygen	91-97	C-X-C motif chemokine ligand 12	Rattus norvegicus	200-205
31038579-9	2019	The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity.	Oxygen	120-126	COPD	Homo sapiens	15-19
30783645-4	2019	Based on the defect properties and migration process, a model of the tritium trapping and migration mechanisms in Li2O is proposed: (1) the bred tritium is first trapped by oxygen vacancies; (2) subsequently the tritium detrapped from oxygen vacancies is retrapped by lithium vacancies, forming T substituents; and (3) the T substituents hop along the Li lattice.	Oxygen	173-179	ATP binding cassette subfamily A member 12	Homo sapiens	114-117
32171198-1	2020	The bifunctional mechanism for the oxygen evolution reaction (OER) involving two distinct reaction sites is studied through the computational hydrogen electrode method for a set of catalyst materials including rutile TiO2(110), anatase TiO2(101), SnO2(110), RuO2(110), IrO2(110), Ni2P(0001), and BiVO4(001).	Oxygen	35-41	strawberry notch homolog 1	Homo sapiens	247-250
30783645-4	2019	Based on the defect properties and migration process, a model of the tritium trapping and migration mechanisms in Li2O is proposed: (1) the bred tritium is first trapped by oxygen vacancies; (2) subsequently the tritium detrapped from oxygen vacancies is retrapped by lithium vacancies, forming T substituents; and (3) the T substituents hop along the Li lattice.	Oxygen	235-241	ATP binding cassette subfamily A member 12	Homo sapiens	114-117
30412717-5	2019	Furthermore, ATG7 knockdown led to an increased survival fraction under oxygen and glutamine starvation, indicating that ionizing radiation indeed induces autophagy which, however, leads to cell death finally.	Oxygen	72-78	autophagy related 7	Homo sapiens	13-17
31881315-2	2020	However, the typical characteristics of hypoxic cells such as low oxygen levels and highly bio-reductive environment can offer stimuli-responsive drug release to aid in tumor-specific chemo, radio, photodyanamic and sonodynamic therapies.	Oxygen	66-72	activation induced cytidine deaminase	Homo sapiens	162-165
31189158-7	2019	Furthermore, in vitrostudies have revealed that the upregulation of BPS on O2-sensitive KV channels was significantly inhibited after treatment with prostaglandin E2 receptor subtype EP4 antagonist GW627368X.	Oxygen	75-77	prostaglandin E receptor 4	Rattus norvegicus	183-186
30783096-5	2019	PD-L1 signaling, which is associated with activation of the MAPK pathway and increased mitochondrial oxygen consumption, is reversed by PD-1 blockade.	Oxygen	101-107	programmed cell death 1	Homo sapiens	136-140
32039429-0	2020	MOF-derived electrocatalysts for oxygen reduction, oxygen evolution and hydrogen evolution reactions.	Oxygen	33-39	lysine acetyltransferase 8	Homo sapiens	0-3
31815118-2	2019	Key transcription factors that recognize xenobiotics or xenobiotic-induced stress such as reactive oxygen species (ROS), include AhR, PXR, CAR, MTF, Nrf2, NF-kappaB, and AP-1.	Oxygen	99-105	aryl hydrocarbon receptor	Homo sapiens	129-132
30712667-0	2019	The Angiotensin II type 1 receptor mediates the effects of low oxygen on early placental angiogenesis.	Oxygen	63-69	angiotensin II receptor type 1	Homo sapiens	4-34
30712667-1	2019	INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1).	Oxygen	52-58	angiopoietin 2	Homo sapiens	217-240
30712667-1	2019	INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1).	Oxygen	52-58	angiopoietin 2	Homo sapiens	242-250
32039429-0	2020	MOF-derived electrocatalysts for oxygen reduction, oxygen evolution and hydrogen evolution reactions.	Oxygen	51-57	lysine acetyltransferase 8	Homo sapiens	0-3
30712667-3	2019	We postulated that the early gestation placental oxygen milieu, by stimulating the angiotensin (Ang) II/AT1R pathway, increases expression of proliferative/angiogenic factors.	Oxygen	49-55	angiotensin II receptor type 1	Homo sapiens	104-108
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	angiopoietin 1	Homo sapiens	179-185
30712667-11	2019	DISCUSSION: Thus, AT1R blockade antagonised the low oxygen induced increase in pro-angiogenic factor expression and cell viability.	Oxygen	52-58	angiotensin II receptor type 1	Homo sapiens	18-22
30712667-12	2019	Our findings highlight a role for an oxygen-sensitive Ang II/AT1R pathway during placentation.	Oxygen	37-43	angiotensin II receptor type 1	Homo sapiens	61-65
30426345-0	2019	Fat-Free Adipose Tissue Mass: Impact on Peak Oxygen Uptake (VO2peak) in Adolescents with and without Obesity.	Oxygen	45-51	FAT atypical cadherin 1	Homo sapiens	0-3
30426345-1	2019	Fat-free body mass (FFM) is a surrogate for skeletal muscle mass and is often used for the normalization of several physiological variables (e.g., oxygen uptake).	Oxygen	147-153	FAT atypical cadherin 1	Homo sapiens	0-3
31984785-6	2020	WABM caused phospho-H2AX increases that were blocked by a reactive oxygen species (ROS) scavenger.	Oxygen	67-73	H2A.X variant histone	Homo sapiens	20-24
31951966-6	2020	Cxcl12 expression was increased following exposure of primary mouse hepatocytes to 1% oxygen.	Oxygen	86-92	chemokine (C-X-C motif) ligand 12	Mus musculus	0-6
30587230-9	2018	Improved cardiorespiratory fitness (increased absolute peak maximal oxygen consumption, or VO2) correlated with reductions in galectin-3 (r = -0.57, P = 0.05 in RA; r = -0.48, P = 0.23 in prediabetes).	Oxygen	68-74	galectin 3	Homo sapiens	126-136
30598843-8	2018	Illustration of educational use: The use of this model is illustrated via the explanation to pediatric residents of the relationships between blood pressures, blood flow rates, ventilation, oxygen saturation, and oxygen distribution in a neonate with TGA.	Oxygen	190-196	T-box transcription factor 1	Homo sapiens	251-254
31944416-1	2020	The HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1alpha and HIF-2alpha.	Oxygen	58-64	egl-9 family hypoxia inducible factor 2	Homo sapiens	29-35
30598843-8	2018	Illustration of educational use: The use of this model is illustrated via the explanation to pediatric residents of the relationships between blood pressures, blood flow rates, ventilation, oxygen saturation, and oxygen distribution in a neonate with TGA.	Oxygen	213-219	T-box transcription factor 1	Homo sapiens	251-254
31492336-5	2020	The Cux/HAP catalyst exhibited a higher catalytic activity for the oxidation of 1,2-propanediol with gaseous oxygen to lactic, acetic, and formic acids with the total selectivity of 70.3% even at a lower reaction temperature of 140  C. The total selectivity of lactic, acetic, and formic acids reached 93.1% at a mild reaction temperature of 180  C. However, the sole monometallic Cu0 nanoparticles or HAP nanorods had no catalytic activity for the oxidation of 1,2-propanediol.	Oxygen	109-115	cut like homeobox 1	Homo sapiens	4-7
33937648-2	2018	The pathophysiology of CS includes elevation of intracompartmental pressure (ICP), causing damage to the microcirculation, decreased oxygen delivery, tissue anoxia, and cell death.	Oxygen	133-139	citrate synthase	Rattus norvegicus	23-25
31866111-6	2020	MCPT4 also dampened systemic neutrophil activation after renal ischemia reperfusion injury as neutrophils expressed more CD11b integrin and produced more reactive oxygen species in MCPT4-deficient mice.	Oxygen	163-169	mast cell protease 4	Mus musculus	0-5
30449100-6	2018	In this work, we present a thermodynamic overview of two such reactions: (a) RO2 + HO2   RO + OH + O2 and (b) R"O2 + RO2   R"O + RO + O2 for selected monoterpene + oxidant derived peroxy radicals.	Oxygen	78-80	heme oxygenase 2	Homo sapiens	83-86
30300333-10	2018	In the oxygen-induced retinopathy model, number of preretinal nuclei (representing pathologic retinal neovascularization) significantly increases by 57% (P&lt;0.05) in hCG-treated mice.	Oxygen	7-13	hypertrichosis 2 (generalised, congenital)	Homo sapiens	168-171
31932812-7	2020	Through activation of EGR1, excessive reactive oxygen species in the tumor microenvironment induce expression of PAC1, which recruits the Mi-2beta nucleosome-remodeling and histone-deacetylase complex, eventually leading to chromatin remodeling of effector T cells.	Oxygen	47-53	dual specificity phosphatase 2	Homo sapiens	113-117
30619851-8	2018	In normoxia, HIFs-alpha are rapidly degraded via the ubiquitin-proteasome pathway, in which PHDs, activated by O2, lead to hydroxylation of HIFs-alpha at residues 402 and 564, followed by recognition by the tumor suppressor protein von Hippel-Lindau (pVHL) as an E3 ligase and ubiquitin labeling.	Oxygen	111-113	von Hippel-Lindau tumor suppressor	Homo sapiens	251-255
31945431-3	2020	We developed and evaluated a new automatable monitoring tool (Early Warning ScoreO2: EWS.O2) that incorporates cardio-respiratory parameters (Respiratory rate, Heart rate, SpO2, and FiO2 derived from oxygen flow rate), aiming to achieve early detection of poor outcome among patients with dyspnea.	Oxygen	200-206	EWS RNA binding protein 1	Homo sapiens	85-88
31458326-8	2018	The Ni-Ag2S system also shows very good stability in ambient atmosphere over a long period of time and suffers no catalytic degradation in the presence of oxygen.	Oxygen	155-161	angiotensin II receptor type 1	Homo sapiens	7-11
31634437-5	2020	The biological function of Cygb involves oxygen delivery, scavenging of reactive oxygen species, and nitric oxide metabolism.	Oxygen	41-47	cytoglobin	Mus musculus	27-31
30448061-10	2018	In contrast, Notch ligand Delta-like 4 (Dll4) and Notch1 intracellular domain (N1-ICD) expression were inhibited in the regressing capillaries of central retina but comparable in the angiogenic plexus after high oxygen treatment.	Oxygen	212-218	delta like canonical Notch ligand 4	Mus musculus	40-44
31634437-5	2020	The biological function of Cygb involves oxygen delivery, scavenging of reactive oxygen species, and nitric oxide metabolism.	Oxygen	81-87	cytoglobin	Mus musculus	27-31
32053662-2	2020	Sre1, the homolog of SREBP in the fission yeast Schizosaccharomyces pombe (S. pombe), regulates genes involved in the transcriptional responses to low sterol as well as low oxygen.	Oxygen	173-179	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	21-26
29524090-7	2018	Multiple regression analysis showed that percentage of sleep time with oxygen saturation &lt; 90% (TST90) and SBP index correlated more with mean level of awakeness and sleep SBP than with apnea-hypopnea index (AHI).	Oxygen	71-77	selenium binding protein 1	Homo sapiens	175-178
29524090-8	2018	Analysis of all apnea events demonstrated that  SBP and the frequency of BP fluctuations were more remarkable following hypoxia than following arousal;  SBP correlated more with oxygen desaturation degree (r = 0.388, p &lt; 0.01) and minimal SpO2 (r = 0.392, p &lt; 0.01) than with apnea length and desaturation duration.	Oxygen	178-184	selenium binding protein 1	Homo sapiens	153-156
31951131-4	2020	Spe-cifically, the two characteristic features observed in both 27Al and 71Ga NMR spectra result from both the deviations in the poly-hedral coordination/site-symmetry within the 4-fold coordinated Li1/24d sites (rather than the doping of the other Li2/96h or La sites) and with the number of occupied adjacent Li2 sites that share oxygen atoms with these dopant sites.	Oxygen	332-338	transglutaminase 1	Homo sapiens	198-201
30497437-6	2018	We also found that the mechanisms triggered by ATRA in non-invasive breast tumor cells cultured under hypoxia is in part mediated by PLC-beta2, responsible to counteract the effects of low oxygen availability on CD133 levels.	Oxygen	189-195	prominin 1	Homo sapiens	212-217
30376334-5	2018	The dominant products in the presence of O2/NO are epoxide, dialdehyde, alcohol ketone, cyclolactone compounds, and HO2 radicals.	Oxygen	41-43	heme oxygenase 2	Homo sapiens	116-119
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	chemokine (C-X-C motif) ligand 15	Mus musculus	94-98
31983610-2	2020	Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis.	Oxygen	77-83	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	112-117
30534005-11	2018	Oxygen evolving complex and PSII complex proteins (PsbH, PsbS, PsbR and Psb28) were found to be abundant in the most damaged leaf zone.	Oxygen	0-6	photosystem II subunit S	Solanum lycopersicum	57-61
30534005-11	2018	Oxygen evolving complex and PSII complex proteins (PsbH, PsbS, PsbR and Psb28) were found to be abundant in the most damaged leaf zone.	Oxygen	0-6	photosystem II 10 kDa polypeptide, chloroplastic	Solanum lycopersicum	63-67
32046347-3	2020	In a mice model of dilated cardiomyopathy (DCM) after autoimmune myocarditis, serum and cardiac sPLA2-IIA protein expression were found to be increased, together with elevated cardiac levels of the cross-linking enzyme lysyl oxidase (LOX) and reactive oxygen species (ROS) accumulation.	Oxygen	252-258	lysyl oxidase	Mus musculus	219-232
31943789-3	2020	By performing a comprehensive analysis of the semaphorins family, we identified the increased expression of Sema4D during oxygen-induced retinopathy (OIR) and streptozotocin (STZ)-induced retinopathy.	Oxygen	122-128	semaphorin 4D	Homo sapiens	108-114
30453511-3	2018	Downregulation of MOR23 by small interfering RNA in 3T3-L1 cells enhanced intracellular lipid accumulation and reduced the oxygen consumption rate.	Oxygen	123-129	olfactory receptor family 10 subfamily J member 5	Mus musculus	18-23
30453511-5	2018	Activation of MOR23 by alpha-cedrene, a novel natural ligand of MOR23, significantly reduced lipid content, increased the oxygen consumption rate, and stimulated reprogramming of the metabolic signature of 3T3-L1 cells, and these changes elicited by alpha-cedrene were absent in MOR23-deficient cells.	Oxygen	122-128	olfactory receptor family 10 subfamily J member 5	Mus musculus	14-19
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Oxygen	58-64	heme oxygenase 2	Homo sapiens	201-204
30334376-4	2018	The composite film demonstrates excellent oxygen reduction/evolution reaction catalytic activities with low Tafel slopes (50 mV dec-1 for oxygen reduction reaction; 92 mV dec-1 for oxygen evolution reaction).	Oxygen	42-48	deleted in esophageal cancer 1	Homo sapiens	128-133
30334376-4	2018	The composite film demonstrates excellent oxygen reduction/evolution reaction catalytic activities with low Tafel slopes (50 mV dec-1 for oxygen reduction reaction; 92 mV dec-1 for oxygen evolution reaction).	Oxygen	42-48	deleted in esophageal cancer 1	Homo sapiens	171-176
31713255-7	2020	The reaction of NADPH in the chemical system with singlet oxygen was found to proceed in two ways, each consisting of two steps, that is, NADPH firstly reacts with 1 O2 barrierlessly to form NADP+ and HO2 - , from which H2 O2 is formed in a spontaneous reaction with H+ , or 1 O2 and H+ initially form 1 HO2 + , which further reacts with NADPH to yield NADP+ and H2 O2 .	Oxygen	58-64	heme oxygenase 2	Homo sapiens	304-307
32099333-9	2020	They were mainly enriched in oxygen-related processes, such as oxidation-reduction process, reactive oxygen species metabolic process, hydrogen peroxide catabolic process, oxidoreductase activity and Peroxisome-related pathway.	Oxygen	29-35	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	172-186
30281301-5	2018	Nitrite and Cys-SNO produced higher amounts of N-NA in the presence of oxygen, whereas NAC-SNO was almost oxygen insensitive.	Oxygen	71-77	strawberry notch homolog 1	Homo sapiens	16-19
32014019-14	2020	However, SLC41A1 and PM20D1 are differentially regulated by AD-related stressors, with only PM20D1 being upregulated by amyloid-beta and reactive oxygen species, and with only PM20D1 being neuroprotective when overexpressed in cell and primary cultures.	Oxygen	146-152	solute carrier family 41 member 1	Homo sapiens	9-16
30370249-7	2018	Cell lines grown in 5% oxygen showed increased expression of the hypoxia-inducible factor 1 (HIF-1) target gene carbonic anhydrase 9 (CA9) and decreased levels of ROS.	Oxygen	23-29	carbonic anhydrase 9	Homo sapiens	112-132
30370249-7	2018	Cell lines grown in 5% oxygen showed increased expression of the hypoxia-inducible factor 1 (HIF-1) target gene carbonic anhydrase 9 (CA9) and decreased levels of ROS.	Oxygen	23-29	carbonic anhydrase 9	Homo sapiens	134-137
32014019-14	2020	However, SLC41A1 and PM20D1 are differentially regulated by AD-related stressors, with only PM20D1 being upregulated by amyloid-beta and reactive oxygen species, and with only PM20D1 being neuroprotective when overexpressed in cell and primary cultures.	Oxygen	146-152	peptidase M20 domain containing 1	Homo sapiens	21-27
32014019-14	2020	However, SLC41A1 and PM20D1 are differentially regulated by AD-related stressors, with only PM20D1 being upregulated by amyloid-beta and reactive oxygen species, and with only PM20D1 being neuroprotective when overexpressed in cell and primary cultures.	Oxygen	146-152	peptidase M20 domain containing 1	Homo sapiens	92-98
30059720-3	2018	All of the alkaloids are S-configured at C-3 and possess an oxygen function at C-6 in the isoquinoline portion, and, thus, belong to the subclass of "Ancistrocladaceae-type" alkaloids.	Oxygen	60-66	complement C6	Homo sapiens	79-82
30527776-6	2019	The relative risks and 95% confidence interval (CI) of incident MetS in the lowest quartiles of HRR 1 and HRR 2 versus the highest quartile were 1.24 (95% CI 1.02 to 1.51) and 2.02 (95% CI 1.58 to 2.60), respectively, after adjusting for potential confounders, including peak oxygen uptake and resting heart rate.	Oxygen	276-282	ETS variant transcription factor 3	Homo sapiens	64-68
32014019-14	2020	However, SLC41A1 and PM20D1 are differentially regulated by AD-related stressors, with only PM20D1 being upregulated by amyloid-beta and reactive oxygen species, and with only PM20D1 being neuroprotective when overexpressed in cell and primary cultures.	Oxygen	146-152	peptidase M20 domain containing 1	Homo sapiens	92-98
30527776-6	2019	The relative risks and 95% confidence interval (CI) of incident MetS in the lowest quartiles of HRR 1 and HRR 2 versus the highest quartile were 1.24 (95% CI 1.02 to 1.51) and 2.02 (95% CI 1.58 to 2.60), respectively, after adjusting for potential confounders, including peak oxygen uptake and resting heart rate.	Oxygen	276-282	nuclear receptor subfamily 1 group H member 4	Homo sapiens	96-101
32015410-1	2020	Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS).	Oxygen	270-276	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	0-26
30563844-3	2019	We undertook the present study to determine whether the O2 dependence of Na+/K+/2Cl- cotransport (catalyzed by Na+/K+/2Cl- cotransporter 1 [NKCC1]) might similarly originate from competition between deoxyHb and a protein involved in NKCC1 regulation for a common binding site on band 3.	Oxygen	56-58	solute carrier family 12, member 2	Mus musculus	111-138
30563844-3	2019	We undertook the present study to determine whether the O2 dependence of Na+/K+/2Cl- cotransport (catalyzed by Na+/K+/2Cl- cotransporter 1 [NKCC1]) might similarly originate from competition between deoxyHb and a protein involved in NKCC1 regulation for a common binding site on band 3.	Oxygen	56-58	solute carrier family 12, member 2	Mus musculus	140-145
30563844-3	2019	We undertook the present study to determine whether the O2 dependence of Na+/K+/2Cl- cotransport (catalyzed by Na+/K+/2Cl- cotransporter 1 [NKCC1]) might similarly originate from competition between deoxyHb and a protein involved in NKCC1 regulation for a common binding site on band 3.	Oxygen	56-58	solute carrier family 12, member 2	Mus musculus	233-238
30676594-3	2019	This allowed evaluation of the role of the CNx graphitic nitrogen in the oxygen reduction reaction (ORR).	Oxygen	73-79	calnexin	Homo sapiens	43-46
28541195-5	2018	Vis-OCT offers depth-resolved angiography and oxygen saturation (sO2) measurements.	Oxygen	46-52	plexin A2	Mus musculus	4-7
30304909-8	2018	A low arterial-alveolar oxygen tension ratio (a/APO2 ratio) was a significant predictor for INSURE failure (P=0.001).	Oxygen	24-30	TNF receptor superfamily member 10a	Homo sapiens	48-52
32015410-1	2020	Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS).	Oxygen	270-276	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	28-32
30262897-6	2018	Culturing OECs at physiologically relevant oxygen tension (2-8%) had a negative impact on p75NTR expression and overall cell survival.	Oxygen	43-49	nerve growth factor receptor	Rattus norvegicus	90-96
31908054-9	2020	More importantly, overexpression of oxygen stable HIF1alpha reversed attenuated proinflammatory and glycolytic gene expression in KLF6-deficient macrophages.	Oxygen	36-42	Kruppel-like factor 6	Mus musculus	130-134
30688319-4	2019	In this work, we find that carbon plays an important synergistic role in improving the performance of La1-xSrxCoO3-delta (0 &lt;= x &lt;= 1) electrocatalysts through the activation of O2 and spillover of radical oxygen intermediates, HO2- and O2-, which is further reduced through chemical decomposition of HO2- on the perovskite surface.	Oxygen	184-186	heme oxygenase 2	Homo sapiens	234-237
30688319-4	2019	In this work, we find that carbon plays an important synergistic role in improving the performance of La1-xSrxCoO3-delta (0 &lt;= x &lt;= 1) electrocatalysts through the activation of O2 and spillover of radical oxygen intermediates, HO2- and O2-, which is further reduced through chemical decomposition of HO2- on the perovskite surface.	Oxygen	184-186	heme oxygenase 2	Homo sapiens	307-310
31957305-0	2020	Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.	Oxygen	11-17	nicotinamide phosphoribosyltransferase	Homo sapiens	28-36
30775442-0	2019	Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans.	Oxygen	65-71	Ion_trans domain-containing protein	Caenorhabditis elegans	25-30
30775442-2	2019	We show here that environmental oxygen concentration affects cold acclimation in Caenorhabditis elegans and that this response is regulated by a KCNQ-type potassium channel, KQT-2.	Oxygen	32-38	Ion_trans domain-containing protein	Caenorhabditis elegans	174-179
30775442-6	2019	Abnormal cold acclimation and acute temperature responses of ADL neurons in kqt-2 mutants were suppressed by an oxygen-receptor mutation in URX coelomic sensory neurons, which are electrically connected to ADL via RMG interneurons.	Oxygen	112-118	Ion_trans domain-containing protein	Caenorhabditis elegans	76-81
30775442-7	2019	Likewise, low oxygen suppressed supranormal kqt-2 cold acclimation.	Oxygen	14-20	Ion_trans domain-containing protein	Caenorhabditis elegans	44-49
30255207-1	2018	The potential energy surface for the first step of the methane oxidation CH4 + O2 CH3 + HO2 was studied using the London-Eyring-Polanyi-Sato equation (LEPS) and the conventional transition-state theory (CTST).	Oxygen	79-81	heme oxygenase 2	Homo sapiens	88-91
30077971-1	2018	Cytochrome c oxidase (CcO) is the terminal oxidase of cellular respiration, reducing O2 to water and pumping protons.	Oxygen	85-87	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
31836547-6	2020	Treatment of HT22 cells with Tat-PGAM1 protein showed a concentration-dependent reduction in cell damage and decreased formation of reactive oxygen species after H2O2 exposure.	Oxygen	141-147	tyrosine aminotransferase	Mus musculus	29-32
30077971-1	2018	Cytochrome c oxidase (CcO) is the terminal oxidase of cellular respiration, reducing O2 to water and pumping protons.	Oxygen	85-87	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
30077971-2	2018	X-ray structural features have suggested that CcO pumps protons via a mechanism involving electrostatic repulsions between pumping protons in the hydrogen-bond network of a proton-conducting pathway (the H-pathway) and net positive charges created upon oxidation of an iron site, heme a (Fe a2+), for reduction of O2 at another iron site, heme a3 (Fe a32+).	Oxygen	314-316	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	46-49
29717493-14	2019	Incubation of PA with Su5416 and hypoxia (3% O2 ) increased miR-1 and induced a decline in Kv1.5 currents, which was prevented by antagomiR-1.	Oxygen	45-47	microRNA 1	Rattus norvegicus	60-65
31836547-6	2020	Treatment of HT22 cells with Tat-PGAM1 protein showed a concentration-dependent reduction in cell damage and decreased formation of reactive oxygen species after H2O2 exposure.	Oxygen	141-147	phosphoglycerate mutase 1	Mus musculus	33-38
31923459-2	2020	Recently it was documented that renin-angiotensin system plays a key role in tissue inflammation, generation of reactive oxygen species (ROS) and tumor necrosis factor-alpha (TNF-alpha) (the principal liver injury mediators) during I/R.	Oxygen	121-127	renin	Rattus norvegicus	32-37
30327337-0	2019	Exercise-Induced Oxygen Desaturation as a Predictive Factor for Longitudinal Decline in 6-Minute Walk Distance in Subjects With COPD.	Oxygen	17-23	COPD	Homo sapiens	128-132
29932269-8	2018	In both M2c and M2a, severe hypoxic (1%-3% O2 ) exposure significantly suppressed PlGF, Cxcl12, and Mmp2 mRNA, but not Vegfa, compared to normoxia (21% O2 ) or physiological hypoxia (5% O2 ).	Oxygen	43-45	placental growth factor	Mus musculus	82-86
29932269-8	2018	In both M2c and M2a, severe hypoxic (1%-3% O2 ) exposure significantly suppressed PlGF, Cxcl12, and Mmp2 mRNA, but not Vegfa, compared to normoxia (21% O2 ) or physiological hypoxia (5% O2 ).	Oxygen	43-45	chemokine (C-X-C motif) ligand 12	Mus musculus	88-94
31894839-6	2020	We also show that EPS1-1 initiated the release of reactive oxygen species (ROS) and liver kinase B1 (LKB1), both of which are necessary signals for AMPK activation.	Oxygen	59-65	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	148-152
30106308-7	2018	In a H2/O2 polymer electrolyte membrane (PEM) fuel cell with H+-conducting Nafion membranes, the black smoker catalyst was effective in reducing O2 but not in oxidizing H2.	Oxygen	8-10	mucin 1, cell surface associated	Homo sapiens	41-44
30106308-7	2018	In a H2/O2 polymer electrolyte membrane (PEM) fuel cell with H+-conducting Nafion membranes, the black smoker catalyst was effective in reducing O2 but not in oxidizing H2.	Oxygen	145-147	mucin 1, cell surface associated	Homo sapiens	41-44
29730341-0	2018	Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy.	Oxygen	74-80	triggering receptor expressed on myeloid cells 1	Mus musculus	12-18
30576923-1	2019	Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen.	Oxygen	181-187	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	28-32
30409785-3	2019	Here, following a previous study devoted to Mg2+ binding to nucleobase nitrogens, we surveyed nucleic acid X-ray structures from the PDB with resolutions &lt;=2.9 A to classify the Mg2+ inner-sphere binding patterns to nucleotide carbonyl, ribose hydroxyl, cyclic ether, and phosphodiester oxygen atoms.	Oxygen	290-296	mucin 7, secreted	Homo sapiens	181-184
30704538-0	2019	Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells.	Oxygen	56-62	microRNA 107	Homo sapiens	16-23
30704538-0	2019	Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells.	Oxygen	56-62	high mobility group box 1	Homo sapiens	84-89
30704538-3	2019	In this study, we investigated the regulation of the miR-107/HMGB1/RAGE pathway in degenerated nucleus pulposus cells (NPCs) after hyperbaric oxygen (HBO) treatment.	Oxygen	142-148	microRNA 107	Homo sapiens	53-60
30704538-3	2019	In this study, we investigated the regulation of the miR-107/HMGB1/RAGE pathway in degenerated nucleus pulposus cells (NPCs) after hyperbaric oxygen (HBO) treatment.	Oxygen	142-148	high mobility group box 1	Homo sapiens	61-66
29663377-0	2018	UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.	Oxygen	24-30	UbiA prenyltransferase domain containing 1	Mus musculus	0-6
32083006-7	2020	Furthermore, we found an increased oxygen respiration rate compensating for HK2 depletion.	Oxygen	35-41	hexokinase 2	Homo sapiens	76-79
30656304-2	2019	The rate of HO2 production as a function of O2 pressure follows Langmuir isotherm behaviour suggesting O2 is involved in the production of HO2 following its adsorption onto the surface of the TiO2 aerosol.	Oxygen	13-15	heme oxygenase 2	Homo sapiens	139-142
30656304-2	2019	The rate of HO2 production as a function of O2 pressure follows Langmuir isotherm behaviour suggesting O2 is involved in the production of HO2 following its adsorption onto the surface of the TiO2 aerosol.	Oxygen	44-46	heme oxygenase 2	Homo sapiens	12-15
31838053-7	2020	We also found that restoration of Nox4 expression abolished the protective effects of farrerol on high glucose-induced proliferation and reactive oxygen species generation.	Oxygen	146-152	NADPH oxidase 4	Homo sapiens	34-38
30656304-2	2019	The rate of HO2 production as a function of O2 pressure follows Langmuir isotherm behaviour suggesting O2 is involved in the production of HO2 following its adsorption onto the surface of the TiO2 aerosol.	Oxygen	44-46	heme oxygenase 2	Homo sapiens	139-142
30656304-6	2019	The increased coverage of H2O onto the TiO2 aerosol surface may inhibit HO2 production by decreasing the effective surface area of the TiO2 particle and lowering the binding energy of O2 on the aerosol surface, hence shortening its desorption lifetime.	Oxygen	41-43	heme oxygenase 2	Homo sapiens	72-75
30656304-7	2019	The maximum yield (i.e. when [O2] is projected to atmospherically relevant levels) for production of gas-phase HO2, normalised for surface area and light intensity, was found to be at a RH of 8.7% for the 80% anatase and 20% rutile formulation of TiO2 used here.	Oxygen	30-32	heme oxygenase 2	Homo sapiens	111-114
29435987-0	2018	The PHD1 oxygen sensor in health and disease.	Oxygen	9-15	egl-9 family hypoxia inducible factor 2	Homo sapiens	4-8
31979226-2	2020	SDHB-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated levels of reactive oxygen species (ROS).	Oxygen	169-175	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	Mus musculus	0-4
30074392-4	2018	This study reports the initial laboratory synthesis and direct detection of MVK-OO through reaction of a photolytically generated, resonance-stabilized monoiodoalkene radical with O2.	Oxygen	180-182	mevalonate kinase	Homo sapiens	76-79
30660106-0	2019	Ternary Heterostructural Pt/CNx/Ni as a Supercatalyst for Oxygen Reduction.	Oxygen	58-64	calnexin	Homo sapiens	28-31
30660106-1	2019	We report here a supercatalyst for oxygen reduction of Pt/CNx/Ni in a unique ternary heterostructure, in which the Pt and the underlying Ni nanoparticles are separated by two to three layers of nitrogen-doped carbon (CNx), which mediates the transfer of electrons from the inner Ni to the outer Pt and protects the Ni against corrosion at the same time.	Oxygen	35-41	calnexin	Homo sapiens	58-61
30660106-1	2019	We report here a supercatalyst for oxygen reduction of Pt/CNx/Ni in a unique ternary heterostructure, in which the Pt and the underlying Ni nanoparticles are separated by two to three layers of nitrogen-doped carbon (CNx), which mediates the transfer of electrons from the inner Ni to the outer Pt and protects the Ni against corrosion at the same time.	Oxygen	35-41	calnexin	Homo sapiens	217-220
29882092-13	2018	Stress in embryos and stem cells increases AMPK in large stimulation indexes but also direness indexes; the fastest AMPK activation occurs when stem cells are shifted from optimal oxygen to lower or high levels (Yang et al., J Reprod Dev 63:87-94, 2017).	Oxygen	180-186	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	116-120
30937261-4	2019	Octet-truss structures with nickel-iron-(oxo) hydroxide nanosheets electrodeposited onto further displays excellent water-splitting performance as catalytic electrodes, i.e., in KOH (1 m, aq), a low oxygen evolution reaction (OER) overpotential of 197 mV at 10 mA cm-2 and Tafel slope of 51 mV dec-1.	Oxygen	199-205	deleted in esophageal cancer 1	Homo sapiens	294-299
31722791-0	2020	Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3beta phosphorylation.	Oxygen	64-70	lemur tyrosine kinase 2	Homo sapiens	18-41
30620016-4	2019	The furfural adsorbs at oxygen vacancy sites in an eta2(C-O) pattern.	Oxygen	24-30	DNA polymerase iota	Homo sapiens	51-55
29756682-2	2018	Here, based on a bioinformatic analysis of cyanobacterial oxygen evolution and reduction enzymes (photosystem II: PS II and cytochrome c oxidase: COX, respectively), the gene encoding the catalytic D1 subunit of PS II was found to be expressed individually across 38 phylogenetically diverse strains, which is in contrast to the operon structure of the genes encoding major COX subunits.	Oxygen	58-64	cytochrome c oxidase subunit 8A	Homo sapiens	146-149
31722791-3	2020	The present study aimed to explore the potential function of LMTK2 in regulating neuronal survival using an in vitro model of oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury.	Oxygen	126-132	lemur tyrosine kinase 2	Homo sapiens	61-66
29756682-2	2018	Here, based on a bioinformatic analysis of cyanobacterial oxygen evolution and reduction enzymes (photosystem II: PS II and cytochrome c oxidase: COX, respectively), the gene encoding the catalytic D1 subunit of PS II was found to be expressed individually across 38 phylogenetically diverse strains, which is in contrast to the operon structure of the genes encoding major COX subunits.	Oxygen	58-64	cytochrome c oxidase subunit 8A	Homo sapiens	374-377
30076663-0	2018	ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast.	Oxygen	36-42	bone morphogenetic protein 4	Homo sapiens	58-62
30596235-5	2019	In contrast, the derivatives of Lu2@C82 (3 and 4) are both normal C2-bonding [5,6,6]-adducts without oxygen addition, even though air is involved in the reaction.	Oxygen	101-107	complement C8 beta chain	Homo sapiens	32-39
30598343-8	2019	However, GLP-1 reduces mixed venous oxygen saturation.	Oxygen	36-42	glucagon like peptide 1 receptor	Homo sapiens	9-14
29462059-0	2018	Effects of Ultra-early Hyperbaric Oxygen Therapy on Femoral Calcitonin Gene-Related Peptide and Bone Metabolism of Rats With Complete Spinal Transection.	Oxygen	34-40	calcitonin-related polypeptide alpha	Rattus norvegicus	60-91
31722791-6	2020	Moreover, LMTK2 overexpression reduced the production of reactive oxygen species (ROS) in OGD/R-exposed neurons.	Oxygen	66-72	lemur tyrosine kinase 2	Homo sapiens	10-15
31927055-9	2020	By evaluating mitochondrial morphology, cytochrome c oxidase activity, ATP level, mitochondrial DNA copy number, and reactive oxygen species, we found that Orexin-A aggravated mitochondrial impairment in APP/PS1 mice and Abeta-treated SH-SY5Y cells.	Oxygen	126-132	hypocretin	Mus musculus	156-164
30059171-4	2018	This creates a 1.5 microm thick protection layer composed of Ge, GeOx , Li2 CO3 , LiOH, LiCl, and Li2 O on Li surface that allows stable cycling of Li electrodes both in Li-symmetrical cells and Li-O2 cells, especially in "moist" electrolytes (with 1000-10 000 ppm H2 O) and humid O2 atmosphere (relative humidity (RH) of 45%).	Oxygen	198-200	ATP binding cassette subfamily A member 12	Homo sapiens	72-75
30059171-4	2018	This creates a 1.5 microm thick protection layer composed of Ge, GeOx , Li2 CO3 , LiOH, LiCl, and Li2 O on Li surface that allows stable cycling of Li electrodes both in Li-symmetrical cells and Li-O2 cells, especially in "moist" electrolytes (with 1000-10 000 ppm H2 O) and humid O2 atmosphere (relative humidity (RH) of 45%).	Oxygen	281-283	ATP binding cassette subfamily A member 12	Homo sapiens	72-75
30091204-6	2019	CB1 R-induced mitochondrial fission was associated with mitochondrial dysfunction, as documented by reduced oxygen consumption and ATP production, increased reactive oxygen species and cellular lactate levels, as well as a decline in mitochondrial biogenesis.	Oxygen	108-114	cannabinoid receptor 1 (brain)	Mus musculus	0-3
31916752-0	2020	Cobalt-Based MOF-on-MOF Two-Dimensional Heterojunction Nanostructures for Enhanced Oxygen Evolution Reaction Electrocatalytic Activity.	Oxygen	83-89	lysine acetyltransferase 8	Homo sapiens	13-16
30247805-6	2018	Cardiac H9c2 cells overexpressing cyto-renin exhibited enhanced nonmitochondrial oxygen consumption, lactate accumulation, and LDH activity, reflecting a switch to more aerobic glycolysis known as Warburg effect.	Oxygen	81-87	renin	Rattus norvegicus	39-44
31916752-0	2020	Cobalt-Based MOF-on-MOF Two-Dimensional Heterojunction Nanostructures for Enhanced Oxygen Evolution Reaction Electrocatalytic Activity.	Oxygen	83-89	lysine acetyltransferase 8	Homo sapiens	20-23
30100910-5	2018	CXCL12 boosted the oxygen consumption rate (OCR), and 2-DG treatment significantly reduced the levels of all measured tricarboxylic acid (TCA) cycle intermediates.	Oxygen	19-25	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
30109776-3	2018	In this paper, exceptionally active electrocatalysts for oxygen-evolution reactions (OERs) were successfully developed and characterized by using SEM, TEM, XRD, BET, and X-ray photoelectron spectroscopy.	Oxygen	57-63	delta/notch like EGF repeat containing	Homo sapiens	161-164
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	Oxygen	98-104	cyclin D1	Homo sapiens	166-175
29848548-7	2018	We found that the most catalytically competent isoform is AtPCO4, both in terms of responding to O2 and oxidizing AtRAP2.2/2,12 (two of the most prominent ERF-VIIs responsible for promoting the hypoxic response), which suggests that AtPCO4 plays a central role in ERF-VII regulation.	Oxygen	97-99	2-aminoethanethiol dioxygenase, putative (DUF1637)	Arabidopsis thaliana	58-64
31963398-6	2020	To that aim, cold atmospheric plasma jets were used to obtain PAR, which produced cytotoxic effects in human OS cells (SaOS-2, MG-63, and U2-OS), related to the increasing concentration of reactive oxygen and nitrogen species generated.	Oxygen	198-204	AFG3-like AAA ATPase 2	Mus musculus	62-65
29848548-7	2018	We found that the most catalytically competent isoform is AtPCO4, both in terms of responding to O2 and oxidizing AtRAP2.2/2,12 (two of the most prominent ERF-VIIs responsible for promoting the hypoxic response), which suggests that AtPCO4 plays a central role in ERF-VII regulation.	Oxygen	97-99	2-aminoethanethiol dioxygenase, putative (DUF1637)	Arabidopsis thaliana	233-239
29763374-7	2018	Further analysis of isolated primary hepatocytes from WT and Tg mice demonstrated that CTRP3 increased oxygen consumption in the presence of fatty acids, indicating that CTRP3 increases hepatic fatty acid utilization.	Oxygen	103-109	C1q and tumor necrosis factor related protein 3	Mus musculus	87-92
29763374-7	2018	Further analysis of isolated primary hepatocytes from WT and Tg mice demonstrated that CTRP3 increased oxygen consumption in the presence of fatty acids, indicating that CTRP3 increases hepatic fatty acid utilization.	Oxygen	103-109	C1q and tumor necrosis factor related protein 3	Mus musculus	170-175
31963398-10	2020	It is shown that the selectivity of PAR is highly dependent on the concentrations of reactive species, being the differential intracellular reactive oxygen species increase and DNA damage between OS cells and hBM-MSCs key mediators for cell apoptosis.	Oxygen	149-155	AFG3-like AAA ATPase 2	Mus musculus	36-39
30210776-4	2018	Moreover, the graphene substrate promoted the full exposure of all active monolayer/few-layer NC, and thus the obtained FeNi@NC/graphene displays the best electrocatalytic properties for the oxygen evolution reaction of all of the previously reported M@NC based catalysts, including the lowest overpotential (261 mV) at 10 mA cm-2 in alkaline electrolyte (1 M KOH), the smallest Tafel slope (40 mV dec-1) and excellent durability for at least 120 h.	Oxygen	191-197	deleted in esophageal cancer 1	Homo sapiens	398-403
31976154-3	2020	We describe the use of combined quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics (MD) simulations to explore the mechanism of PHF8, including dioxygen activation, 2OG binding modes, and substrate demethylation steps.	Oxygen	162-170	PHD finger protein 8	Homo sapiens	146-150
29947226-7	2018	Furthermore, the 2D Co3O4 ultrathin nanomeshes show an outstanding performance for the oxygen evolution reaction with an overpotential of 230 mV at the onset potential and a small Tafel slope of 74.0 mV dec-1.	Oxygen	87-93	deleted in esophageal cancer 1	Homo sapiens	203-208
29931197-9	2018	Interestingly, also human fibroblasts from Marfan (FBN1) and LDS (TGFBR2 and SMAD3) patients showed lower oxygen consumption.	Oxygen	106-112	transforming growth factor beta receptor 2	Homo sapiens	66-72
29931197-9	2018	Interestingly, also human fibroblasts from Marfan (FBN1) and LDS (TGFBR2 and SMAD3) patients showed lower oxygen consumption.	Oxygen	106-112	SMAD family member 3	Homo sapiens	77-82
29931197-16	2018	Activation of PGC1alpha restored the decreased oxygen consumption in Fibulin-4R/R VSMCs and improved their reduced growth potential, emphasizing the importance of this key regulator.	Oxygen	47-53	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-23
30468455-0	2018	Autologous oxygen release nano bionic scaffold composite miR-106a induced BMSCs enhances osteoblast conversion and promotes bone repair through regulating BMP-2.	Oxygen	11-17	bone morphogenetic protein 2	Rattus norvegicus	155-160
30468455-11	2018	RESULTS: Autologous oxygen release nano bionic scaffold composite BMSCs significantly increased local bone mineral density, promoted callus healing, facilitated ALP secretion, elevated collagen II expression, and up-regulated BMP-2 mRNA and protein levels compared with fracture group (p&lt;0.05).	Oxygen	20-26	bone morphogenetic protein 2	Rattus norvegicus	226-231
30468455-13	2018	CONCLUSIONS: Autologous oxygen release nano bionic scaffold composite miR-106a induced BMSCs enhanced osteoblast conversion and promoted bone repair through regulating BMP-2.	Oxygen	24-30	bone morphogenetic protein 2	Rattus norvegicus	168-173
29912547-3	2018	The surface area of Li1.2Mn0.54Ni0.13Co0.13O2 crystals where the spinel phase is located possesses sufficient Li and O vacancies, resulting in the reinsertion of Li into position after the first charge and maintenance of the interface stability via the replenishment of oxygen from the bulk region.	Oxygen	270-276	transglutaminase 1	Homo sapiens	20-23
31816612-5	2020	In the present study, we verify the PID correction method for helium-, oxygen-, and neon-ion beams.	Oxygen	71-77	metastasis associated 1 family member 2	Homo sapiens	36-39
30105105-3	2018	VHL protein acts as a tumor suppressor by targeting hypoxia-inducible factors (HIFs) for degradation through an oxygen-dependent mechanism.	Oxygen	112-118	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
29980690-1	2018	Signaling by members of the transforming growth factor-beta (TGF-beta) superfamily, such as TGF-beta3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology.	Oxygen	116-122	transforming growth factor alpha	Homo sapiens	61-69
30419265-7	2018	All of these alkaloids are S-configured at C-3 and bear an oxygen function at C-6, and are, thus, typical Ancistrocladaceae-type compounds.	Oxygen	59-65	complement C6	Homo sapiens	78-81
30409713-4	2018	OIR was induced in neonatal mice by exposure to 80% oxygen from postnatal day (P) 7 to P10 and to atmospheric oxygen from P10 to P15.	Oxygen	52-58	S100 calcium binding protein A10 (calpactin)	Mus musculus	87-90
31812751-9	2020	As compared with H2O2-treatment alone, the pretreatment of the cells with 100, 200 and 400 mug/mL of GA-g-CMCS significantly increased cell viability, reduced apoptosis and intracellular reactive oxygen species production, and improved membrane integrity and intracellular antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase) activity.	Oxygen	196-202	cerebral malaria susceptibility in CBA/N	Mus musculus	106-110
30409713-4	2018	OIR was induced in neonatal mice by exposure to 80% oxygen from postnatal day (P) 7 to P10 and to atmospheric oxygen from P10 to P15.	Oxygen	110-116	S100 calcium binding protein A10 (calpactin)	Mus musculus	122-125
29980690-2	2018	The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension on the single or combined treatment with TGF-beta3 and BMP7 on OA chondrocyte redifferentiation in three dimensional (3D) pellet cultures.	Oxygen	138-144	transforming growth factor beta 3	Homo sapiens	194-203
29980690-8	2018	Our data underscores the important modulatory role of oxygen tension on the chondrocyte"s responsiveness to TGF-beta3 and/or BMP7.	Oxygen	54-60	transforming growth factor beta 3	Homo sapiens	108-117
30097722-3	2018	AOX catalyzes the oxidation of quinol and the reduction of oxygen into water.	Oxygen	59-65	alternative oxidase 2	Arabidopsis thaliana	0-3
31618435-2	2020	Hypoxia-inducible transcription factor prolyl hydroxylase-containing enzymes (PHD1, PHD2, and PHD3) are molecular oxygen sensors that control adaptive gene expression through hypoxia-inducible factor (HIF).	Oxygen	114-120	egl-9 family hypoxia inducible factor 2	Homo sapiens	78-82
30305109-7	2018	RESULTS: PASMC proliferation was increased by moderate hypoxia (3% oxygen) but was reduced by severe hypoxia (0.1% oxygen) after 48 h. Moderate hypoxia induced miR-17-5p expression.	Oxygen	115-121	microRNA 17	Homo sapiens	160-169
29725923-9	2018	A series of free radical trapping experiments showed that  O2- played a crucial role in the degradation of AO7.	Oxygen	59-61	ring finger protein 25	Homo sapiens	107-110
32138537-8	2020	The western blot and real-time PCR data revealed that hypoxic stress with 2.5% O2 suppressed the expression of miR-145 and Wnt3a/beta-catenin in cultured rat cardiomyocytes but augmented Dab2.	Oxygen	79-81	Wnt family member 3A	Rattus norvegicus	123-128
29626198-1	2018	Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels.	Oxygen	214-220	aryl hydrocarbon receptor	Homo sapiens	0-25
29626198-1	2018	Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels.	Oxygen	214-220	aryl hydrocarbon receptor	Homo sapiens	27-30
30305668-9	2018	PGC1-alpha, TFAM and Ucp1 mRNA levels were robustly downregulated by miR-494-3p overexpression in 3T3-L1 beige adipocytes, along with strongly decreased oxygen consumption rate.	Oxygen	153-159	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	0-10
30305668-9	2018	PGC1-alpha, TFAM and Ucp1 mRNA levels were robustly downregulated by miR-494-3p overexpression in 3T3-L1 beige adipocytes, along with strongly decreased oxygen consumption rate.	Oxygen	153-159	transcription factor A, mitochondrial	Mus musculus	12-16
30305668-9	2018	PGC1-alpha, TFAM and Ucp1 mRNA levels were robustly downregulated by miR-494-3p overexpression in 3T3-L1 beige adipocytes, along with strongly decreased oxygen consumption rate.	Oxygen	153-159	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	21-25
29892061-7	2018	We further show that SMARCA4 mutant cells have enhanced oxygen consumption and increased respiratory capacity.	Oxygen	56-62	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	21-28
31678492-0	2020	Induction of an MLKL mediated non-canonical necroptosis through reactive oxygen species by tanshinol A in lung cancer cells.	Oxygen	73-79	mixed lineage kinase domain like pseudokinase	Homo sapiens	16-20
29230937-5	2018	Additionally, the transgenic plants reduced H2 O2 and O2 - accumulation under salinity, which could be due to up-regulation of ROS scavenger activities such as SOD, APX and CAT as well as CmHSP70, CmHSP90.	Oxygen	47-49	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	165-168
30279321-2	2018	Mitochondria are the source of up to 90% of cellular ROS generation, and MnSOD performs its necessary bioprotective role by converting superoxide into oxygen and hydrogen peroxide.	Oxygen	151-157	superoxide dismutase 2	Homo sapiens	73-78
31678492-3	2020	Here, we described an MLKL mediated non-canonical necroptosis through reactive oxygen species (ROS) in lung cancer cells triggered by a natural compound, tanshinol A (TSA).	Oxygen	79-85	mixed lineage kinase domain like pseudokinase	Homo sapiens	22-26
30318520-0	2018	Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2-  production in cancer cells.	Oxygen	75-77	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	24-28
30318520-0	2018	Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2-  production in cancer cells.	Oxygen	75-77	uncoupling protein 2	Homo sapiens	40-44
30104163-5	2018	This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression.	Oxygen	67-73	tetratricopeptide repeat domain 12	Homo sapiens	224-229
29806451-8	2018	FAU can be used for the separation of carbon dioxide from carbon monoxide and oxygen and BRE or MTW for the separation of carbon monoxide from oxygen.	Oxygen	78-84	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	0-3
29806451-8	2018	FAU can be used for the separation of carbon dioxide from carbon monoxide and oxygen and BRE or MTW for the separation of carbon monoxide from oxygen.	Oxygen	143-149	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	0-3
29884814-1	2018	The Great Oxidation Event (GOE) has been defined as the time interval when sufficient atmospheric oxygen accumulated to prevent the generation and preservation of mass-independent fractionation of sulphur isotopes (MIF-S) in sedimentary rocks.	Oxygen	98-104	macrophage migration inhibitory factor	Homo sapiens	215-218
31490096-0	2020	Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.	Oxygen	21-27	NADPH oxidase 4	Homo sapiens	114-118
29938199-2	2018	These tumors are usually initiated by biallelic gene inactivation of the Von Hippel-Lindau (VHL) factor in the renal epithelium, which deregulates the hypoxia-inducible factors (HIFs) HIF1alpha and HIF2alpha, and provokes their constitutive activation irrespective of the cellular oxygen availability.	Oxygen	281-287	von Hippel-Lindau tumor suppressor	Homo sapiens	73-90
30285008-2	2018	The aim was to evaluate oxygen perfusion in the skin in the area of late radiation injury manifested as RIF in patients with breast cancer.	Oxygen	24-30	ras homolog family member F, filopodia associated	Homo sapiens	104-107
30285008-4	2018	RESULTS: Partial oxygen pressure tcpO2 in the RIF area in patients with breast cancer didn"t show any significant decrease compared to healthy tissue.	Oxygen	17-23	ras homolog family member F, filopodia associated	Homo sapiens	46-49
30285008-5	2018	Mean value of partial oxygen pressure tcpO2 in the RIF area was 42.650 +- 9.178 mmHg, in the healthy tissue it was 45.180 +- 8.025 mmHg.	Oxygen	22-28	ras homolog family member F, filopodia associated	Homo sapiens	51-54
31314602-0	2020	Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.	Oxygen	33-39	stanniocalcin 1	Mus musculus	0-15
30026868-4	2018	Based on encapsulation of doxorubicin (DOX) and chlorin e6 (Ce6) into HPOCs to form ODC-HPOCs, the mechanism and therapeutic efficacy of oxygen-enhanced chemo-PDT was investigated in vitro and in vivo.	Oxygen	137-143	ornithine decarboxylase 1	Homo sapiens	84-87
33130681-0	2020	miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3.	Oxygen	33-39	microRNA 325	Homo sapiens	0-7
29608244-11	2018	The strong anti-angiogenic effect of miR-181a was also displayed on the retinal neovascularization of the in vivo mouse model of oxygen-induced retinopathy.	Oxygen	129-135	microRNA 181a-2	Mus musculus	37-45
30237125-0	2018	FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1alpha.	Oxygen	34-40	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	12-17
30237125-5	2018	We here found that human FIH (factor inhibiting HIF) hydroxylates human NAA10 at W38 oxygen-dependently and this permits NAA10 to express the lysyl-acetyltransferase activity.	Oxygen	85-91	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	72-77
30237125-5	2018	We here found that human FIH (factor inhibiting HIF) hydroxylates human NAA10 at W38 oxygen-dependently and this permits NAA10 to express the lysyl-acetyltransferase activity.	Oxygen	85-91	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	121-126
30237125-7	2018	Since the FIH-dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia.	Oxygen	54-60	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	41-46
30237125-9	2018	This study provides a novel oxygen-sensing process that determines the substrate specificity of NAA10 depending on an ambient oxygen tension.	Oxygen	28-34	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	96-101
30237125-9	2018	This study provides a novel oxygen-sensing process that determines the substrate specificity of NAA10 depending on an ambient oxygen tension.	Oxygen	126-132	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	96-101
31405617-9	2020	Spirometric stages of the GOLD classification were not correlated with a higher risk of PA. Four independent predictive factors of PA in COPD patients were identified: home oxygen therapy (OR: 4.39; 95% CI: 1.60-12.01; P=.004), bronchiectasis (OR: 3.61; 95% CI: 1.40-9.30; P=.008), hospital admission in the previous three months (OR: 3.12; 95% CI: 1.24-7.87; P=.016) and antifungal therapy against Candida spp.	Oxygen	173-179	histocompatibility minor 13	Homo sapiens	407-410
30178652-0	2018	Rapid Synthesis of Oxygen-Rich Covalent C2N (CNO) Nanosheets by Sacrifice of HKUST-1: Advanced Metal-Free Nanofillers for Polymers.	Oxygen	19-25	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	45-48
30178652-1	2018	A covalent oxygen-rich C2N (CNO) network derived from metal-organic framework (HKUST-1) was innovatively synthesized by a rapid and green microwave irradiation method.	Oxygen	11-17	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	28-31
29935641-9	2018	Culture in 2% O2 was associated with significantly fewer cells in early and advanced blastocysts, alteration in relative abundances of anabolic amino acids and metabolites involved in redox homeostasis, and differential expression of MUC1 in trophectoderm.	Oxygen	14-16	mucin 1, cell surface associated	Homo sapiens	234-238
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	lysine (K)-specific demethylase 4C	Mus musculus	258-263
31914666-4	2020	Here, we investigated the role of Wnt/Frizzled-7 (Fzd7) pathway in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	84-90	frizzled class receptor 7	Mus musculus	50-54
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	caspase 1	Mus musculus	309-318
30254296-7	2018	We discovered that cell death occurs through a YAP-independent mechanism, predominately involving binding of free iron and likely through redox cycling, contributes to production of reactive oxygen species.	Oxygen	191-197	Yes1 associated transcriptional regulator	Homo sapiens	47-50
31210352-0	2020	MicroRNA-132 protects H9c2 cells against oxygen and glucose deprivation-evoked injury by targeting FOXO3A.	Oxygen	41-47	forkhead box O3	Rattus norvegicus	99-105
30148606-2	2018	Herein, we report a washing-free and sensitive (competitive) displacement immunosensor for cortisol in human serum, based on electron mediation of Os(bpy)2Cl2 between an electrode and a redox label [oxygen-insensitive diaphorase (DI)] (i.e., electrochemical-enzymatic redox cycling).	Oxygen	199-205	dihydrolipoamide dehydrogenase	Homo sapiens	218-228
30148606-2	2018	Herein, we report a washing-free and sensitive (competitive) displacement immunosensor for cortisol in human serum, based on electron mediation of Os(bpy)2Cl2 between an electrode and a redox label [oxygen-insensitive diaphorase (DI)] (i.e., electrochemical-enzymatic redox cycling).	Oxygen	199-205	dihydrolipoamide dehydrogenase	Homo sapiens	230-232
29908183-0	2018	MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway.	Oxygen	21-27	macrophage migration inhibitory factor	Homo sapiens	0-3
29783640-0	2018	The Effect of Light Intensity, Temperature, and Oxygen Pressure on the Photo-Oxidation Rate of Bare PbS Quantum Dots.	Oxygen	48-54	cholinergic receptor muscarinic 3	Homo sapiens	100-103
29580991-2	2018	The stability and transcriptional activity of this protein are oxygen-dependently regulated by the prolyl hydroxylases PHD1-3 and the asparaginyl hydroxylase FIH.	Oxygen	63-69	egl-9 family hypoxia inducible factor 2	Homo sapiens	119-125
29725060-5	2018	In the present study, we show that CPT1C is also expressed in hMSCs and protects them against glucose starvation, glycolysis inhibition, and oxygen/glucose deprivation.	Oxygen	141-147	carnitine palmitoyltransferase 1C	Homo sapiens	35-40
31539803-0	2020	The NOTCH1-dependent HIF1alpha/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation.	Oxygen	45-51	interferon regulatory factor 2 binding protein 2b	Danio rerio	37-44
29526808-1	2018	A single nucleotide polymorphism in Ncf1 has been found with a major effect on chronic inflammatory autoimmune diseases in the rat with the surprising observation that a lower reactive oxygen response led to more severe diseases.	Oxygen	185-191	neutrophil cytosolic factor 1	Rattus norvegicus	36-40
33063053-7	2020	We described the most recent developed breathing aid devices such as oxygen therapy devices, ventilator, and CPAP throughout the review.	Oxygen	69-75	activation induced cytidine deaminase	Homo sapiens	49-52
30060096-4	2018	The expression of genes encoding prorenin (REN), angiotensinogen, (pro)renin receptor, angiotensin converting enzyme 2, and the angiotensin II type 1 receptor are highest in early gestation, at a time when oxygen tension is at its lowest.	Oxygen	206-212	angiotensin II receptor type 1	Homo sapiens	128-158
29514048-4	2018	Exposure of HUVEC and VVEC to 1% O2 for 4-24 h triggered rather moderate activation of ATP breakdown into adenosine via the CD39-CD73 axis.	Oxygen	33-35	5'-nucleotidase ecto	Homo sapiens	129-133
31735020-0	2019	Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells.	Oxygen	46-52	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-28
29414176-1	2018	In this work, a microbial desalination cell (MDC) was employed to desalinate the FO treated leachate for reduction of both salinity and chemical oxygen demand (COD).	Oxygen	145-151	C-C motif chemokine ligand 22	Homo sapiens	45-48
30066872-6	2018	Moreover, TUG1 expression was positively correlated with the degree of fibrosis but negatively correlated with pulse oxygen saturation.	Oxygen	117-123	taurine up-regulated 1	Homo sapiens	10-14
30175552-8	2018	Plasma oxygen, glucose, and insulin concentrations were 25%, 22%, and 84% lower in IGF-1 fetuses, respectively (P &lt; 0.05).	Oxygen	7-13	insulin-like growth factor I	Ovis aries	83-88
28851233-0	2018	Shuttle walk tests in people with COPD who demonstrate exercise-induced oxygen desaturation: An analysis of test repeatability and cardiorespiratory responses.	Oxygen	72-78	COPD	Homo sapiens	34-38
31878047-9	2019	Reactive oxygen species (ROS) appeared to play a key role in ASC stimulation as the inhibition of ROS generation and NOX4 knockout attenuated ASC stimulation and THPO upregulation by HB-EGF.	Oxygen	9-15	NADPH oxidase 4	Homo sapiens	117-121
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	87-89	matrix metallopeptidase 9	Mus musculus	38-43
28443368-4	2018	The MDC also produced the maximum power density of 47.1 W m-3 and the averaged chemical oxygen demand (COD) removal of 58.2 +- 0.89% when the initial COD was 6610 +- 83 mg L-1.	Oxygen	88-94	C-C motif chemokine ligand 22	Homo sapiens	4-7
31629659-0	2019	KDM3A Senses Oxygen Availability to Regulate PGC-1alpha-Mediated Mitochondrial Biogenesis.	Oxygen	13-19	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	45-55
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	113-115	matrix metallopeptidase 9	Mus musculus	38-43
30150759-7	2018	Second, 13 differentially expressed genes associated with energy and O2 consumption processes under soil flooding had lower transcript levels in LS1 than those in LS2, which might contribute to better energy-/O2-saving abilities and behaviours in flood-tolerant LS1 than those in flood-susceptible LS2 under hypoxic stress.	Oxygen	69-71	serpin family D member 1	Homo sapiens	163-166
31629659-2	2019	However, how PGC-1alpha is regulated in response to oxygen availability remains unclear.	Oxygen	52-58	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-23
30150759-7	2018	Second, 13 differentially expressed genes associated with energy and O2 consumption processes under soil flooding had lower transcript levels in LS1 than those in LS2, which might contribute to better energy-/O2-saving abilities and behaviours in flood-tolerant LS1 than those in flood-susceptible LS2 under hypoxic stress.	Oxygen	69-71	serpin family D member 1	Homo sapiens	298-301
29407213-5	2018	Noggin repressed the increase in hepcidin and ferritin levels in BV2 exposed to lipopolysaccharide (LPS) and oxygen/glucose deprivation and reperfusion (OGD/R).	Oxygen	109-115	noggin	Homo sapiens	0-6
31629659-7	2019	This study revealed that PGC-1alpha monomethylation, which is dependent on oxygen availability-regulated KDM3A, plays a critical role in the regulation of mitochondrial biogenesis.	Oxygen	75-81	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	25-35
31817513-6	2019	Low levels of oxygen can also promote the process through several other secondary factors, including ANGPT2, FGF, and HGF.	Oxygen	14-20	angiopoietin 2	Homo sapiens	101-107
30135298-8	2018	Strikingly, PPARgamma inhibition reversed hepatic Aloxe3-mediated insulin sensitization, suppression of hepatocellular ATP production and oxygen consumption, and gene induction of PPARgamma coactivator-1alpha (PGC1alpha) expression.	Oxygen	138-144	peroxisome proliferator activated receptor gamma	Mus musculus	12-21
29532965-2	2018	The anionic oxygen redox induced by activation of the Li2 MnO3 domain has previously afforded an O3-type layered Li-rich material used as the cathode for lithium-ion batteries with a notably high capacity of 250-300 mAh g-1 .	Oxygen	12-18	ATP binding cassette subfamily A member 12	Homo sapiens	54-57
31817513-6	2019	Low levels of oxygen can also promote the process through several other secondary factors, including ANGPT2, FGF, and HGF.	Oxygen	14-20	hepatocyte growth factor	Homo sapiens	118-121
29532965-5	2018	The activation of a single-layer Li2 MnO3 enables stable anionic oxygen redox reactions and leads to a highly reversible charge-discharge cycle.	Oxygen	65-71	ATP binding cassette subfamily A member 12	Homo sapiens	33-36
29351410-9	2018	The basal protein expression levels of STIM1/2, Orai1/2, and TRPC6 were higher in CASMC than in PASMC, but hypoxia (3% O2 for 72 h) significantly upregulated protein expression levels of STIM1/STIM2, Orai1/Orai2, and TRPC6 and increased the resting [Ca2+]cyt only in PASMC, but not in CASMC.	Oxygen	119-121	transient receptor potential cation channel subfamily C member 6	Homo sapiens	217-222
30082380-1	2018	The signature of mass-independent fractionation of quadruple sulfur stable isotopes (S-MIF) in Archean rocks, ice cores, and Martian meteorites provides a unique probe of the oxygen and sulfur cycles in the terrestrial and Martian paleoatmospheres.	Oxygen	175-181	macrophage migration inhibitory factor	Homo sapiens	87-90
30033085-3	2018	Using a human induced pluripotent stem cell-derived liver bud (hiPSC-LB) model, we found hypoxia induced with an O2-permeable plate promoted hepatic differentiation accompanied by TGFB1 and TGFB3 suppression.	Oxygen	113-115	transforming growth factor beta 3	Homo sapiens	190-195
31867267-6	2019	Knockdown of MTHFD1L reduced nicotinamide adenine dinucleotide phosphate (NADPH) levels and increased reactive oxygen species (ROS), which accelerated cell death under oxidative stress, such as hypoxia or glucose deprivation.	Oxygen	111-117	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	13-20
30097798-4	2018	The amount of remained oxygen atoms near the GaN surface was found to decrease for the thicker AlN.	Oxygen	23-29	gigaxonin	Homo sapiens	45-48
29373688-13	2018	Conclusions: Our study uncovers epigenetic regulation of VHL and its functional consequences for altered oxygen and iron homeostasis in preeclampsia.	Oxygen	105-111	von Hippel-Lindau tumor suppressor	Homo sapiens	57-60
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	mitogen activated protein kinase 3	Rattus norvegicus	273-280
29673115-6	2018	This was associated with an enhanced isoproterenol-induced oxygen consumption rate of WAT explants from sg/sg mice, which was reproducible in WT explants by treatment with a RORalpha inverse agonist SR 3335, that induced a parallel increase in the UCP1 protein.	Oxygen	59-65	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	248-252
30009303-4	2018	More strikingly, the V-Hex structure is energetically as stable as black phosphorene, but possesses distinctly superior chemical stability when exposed to O2 due to the presence of a much higher activation barrier against chemisorption.	Oxygen	155-157	hematopoietically expressed homeobox	Homo sapiens	23-26
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	mitogen activated protein kinase 3	Rattus norvegicus	292-299
31602731-3	2019	ADR is equipped with chemiluminescence and near-infrared fluorescence (NIRF) signaling channels that can be activated by oxidative stress (superoxide anion, O2 .- ) and lysosomal damage (N-acetyl-beta-d-glucosaminidase, NAG), respectively.	Oxygen	157-159	O-GlcNAcase	Mus musculus	187-218
29957938-7	2018	The rate constants for the four diol oxidation reactions were investigated using the MESMER master equation solver kinetics code over the temperature range between 200 and 300 K. The calculations suggest that once formed, gem diol radicals react rapidly with O2 in the atmosphere to produce organic acids and HO2 with an effective gas phase bimolecular rate constant of ~1 x 10-11 cm3/molecule s at 300 K.	Oxygen	259-261	heme oxygenase 2	Homo sapiens	309-312
29493384-1	2018	The long-term oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD) has been shown to increase survival in patients with severe resting hypoxemia.	Oxygen	14-20	COPD	Homo sapiens	93-97
31871542-0	2019	NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells.	Oxygen	24-30	neurotrophic receptor tyrosine kinase 1	Homo sapiens	83-87
28870773-1	2018	Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP.	Oxygen	73-79	cytochrome c oxidase subunit 8A	Homo sapiens	36-39
29665148-2	2018	Placental regional changes in oxygen availability and oxidative stress indices may influence regional differences in expression of MMPs.	Oxygen	30-36	matrix metallopeptidase 2	Homo sapiens	131-135
31137980-2	2019	We postulated that the impaired skin barrier function was associated with reactive oxygen species derived from gp91phox.	Oxygen	83-89	cytochrome b-245, beta polypeptide	Mus musculus	111-119
30134834-2	2018	In this study, we advanced the translational potential of adenosine A2A receptor (A2AR) antagonists as a novel therapeutic strategy for selectively controlling pathological retinal neovascularization in oxygen-induced retinopathy (OIR) model of ROP.	Oxygen	203-209	adenosine A2a receptor	Mus musculus	58-80
30134834-2	2018	In this study, we advanced the translational potential of adenosine A2A receptor (A2AR) antagonists as a novel therapeutic strategy for selectively controlling pathological retinal neovascularization in oxygen-induced retinopathy (OIR) model of ROP.	Oxygen	203-209	adenosine A2a receptor	Mus musculus	82-86
28972150-3	2018	As a result, we now appreciate that COX relies on its redox-active metal centers (heme a and a3, CuA and CuB) to reduce oxygen and pump protons in a reaction essential for most eukaryotic life.	Oxygen	120-126	cytochrome c oxidase subunit 8A	Homo sapiens	36-39
31563783-3	2019	Here, we identified a tomato glutaredoxin gene GRXS25 which was induced by 24-epibrassinolide (EBR) and chlorothalonil (CHT) in a way dependent on apoplastic reactive oxygen species (ROS).	Oxygen	167-173	glutaredoxin	Solanum lycopersicum	29-41
29596329-4	2018	To illustrate such halogen-pi interactions using drugs that are major substrates of CYP2B6, we present here a crystal structure of CYP2B6 in complex with an analog of the widely used anti-HIV drug efavirenz, which contains a methyl group in place of the carbonyl oxygen.	Oxygen	263-269	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	84-90
29596329-4	2018	To illustrate such halogen-pi interactions using drugs that are major substrates of CYP2B6, we present here a crystal structure of CYP2B6 in complex with an analog of the widely used anti-HIV drug efavirenz, which contains a methyl group in place of the carbonyl oxygen.	Oxygen	263-269	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	131-137
29882412-6	2018	Moreover, it shows a small overpotential of 293 mV with a Tafel slope of 59.7 mV dec-1 to reach 10 mA cm-2 for the oxygen evolution reaction (OER) in 1.0 M KOH.	Oxygen	115-121	deleted in esophageal cancer 1	Homo sapiens	81-86
29643061-7	2018	Multiple in vivo mitochondrial measures related to HbA1c These data suggest that oxygen availability is rate limiting for in vivo mitochondrial oxidative exercise recovery measured with 31P-MRS in individuals with uncomplicated diabetes.	Oxygen	81-87	hemoglobin subunit alpha	Bos taurus	51-55
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	haptoglobin-related protein	Homo sapiens	67-70
29590585-10	2018	We find that DeltaDeltaGhyd, the change of the Mg2+ hydration free energy upon binding to RNA, varies linearly with the inverse distance between the Mg2+ ion and the nearby nonbridging oxygen atoms of the phosphate groups, and DeltaDeltaGhyd can reach -2.0 kcal/mol and -3.0 kcal/mol for an Mg2+ ion bound to the surface and to the groove interior, respectively.	Oxygen	185-191	mucin 7, secreted	Homo sapiens	47-50
29590585-10	2018	We find that DeltaDeltaGhyd, the change of the Mg2+ hydration free energy upon binding to RNA, varies linearly with the inverse distance between the Mg2+ ion and the nearby nonbridging oxygen atoms of the phosphate groups, and DeltaDeltaGhyd can reach -2.0 kcal/mol and -3.0 kcal/mol for an Mg2+ ion bound to the surface and to the groove interior, respectively.	Oxygen	185-191	mucin 7, secreted	Homo sapiens	149-152
29590585-10	2018	We find that DeltaDeltaGhyd, the change of the Mg2+ hydration free energy upon binding to RNA, varies linearly with the inverse distance between the Mg2+ ion and the nearby nonbridging oxygen atoms of the phosphate groups, and DeltaDeltaGhyd can reach -2.0 kcal/mol and -3.0 kcal/mol for an Mg2+ ion bound to the surface and to the groove interior, respectively.	Oxygen	185-191	mucin 7, secreted	Homo sapiens	149-152
29527609-6	2018	Through the condition optimization, the enhanced electrocatalytic activity with an onset potential of 0.87 V versus the normal hydrogen electrode (NHE) towards oxygen evolution reaction with the highest Faradaic efficiency of 99% could be obtained.	Oxygen	160-166	solute carrier family 9 member C1	Homo sapiens	147-150
29604396-11	2018	Taken together these results suggest that hypoxic NO generation mediated by AOX has a discrete role by feeding into the haemoglobin-NO cycle to drive energy efficiency under conditions of low oxygen tension.	Oxygen	192-198	alternative oxidase 2	Arabidopsis thaliana	76-79
29785863-0	2018	Hyperbaric oxygen inhibits production of CD3+ T cells in the thymus and facilitates malignant glioma cell growth.	Oxygen	11-17	CD3 antigen, epsilon polypeptide	Mus musculus	41-44
31568847-6	2019	In vitro experiments suggest the involvement of the reactive oxygen species (ROS)-HhIP-Gli1-autophagy axis in DBP-treated primary rat urethral epithelial cells.	Oxygen	61-67	Hedgehog-interacting protein	Rattus norvegicus	82-86
29442644-2	2018	Herein, we reported a mesoporous catalyst with iron-carboxylate metal-organic framework (MOF) as precursors to catalyze O2 to hydrogen peroxide (H2O2).	Oxygen	120-122	lysine acetyltransferase 8	Homo sapiens	64-93
29339571-0	2018	Infrared photoconductivity and photovoltaic response from nanoscale domains of PbS alloyed with thorium and oxygen.	Oxygen	108-114	cholinergic receptor muscarinic 3	Homo sapiens	79-82
31568847-6	2019	In vitro experiments suggest the involvement of the reactive oxygen species (ROS)-HhIP-Gli1-autophagy axis in DBP-treated primary rat urethral epithelial cells.	Oxygen	61-67	GLI family zinc finger 1	Rattus norvegicus	87-91
29442644-5	2018	The pyrolysis of Fe-MOF with the largest amount of mesopores resulted in its carbonization and produced gamma-Fe2O3@carbon material, significantly reduced the BET surface area from 3036 m2 g-1 to 387 m2 g-1, but increased the average pore diameter up to 5.78 nm and disintegrated their octahedral structures to an irregular morphology of Fe-MOF (550), and modified the carbon matrix with trace oxygen and metal oxides.	Oxygen	394-400	lysine acetyltransferase 8	Homo sapiens	20-23
29442644-5	2018	The pyrolysis of Fe-MOF with the largest amount of mesopores resulted in its carbonization and produced gamma-Fe2O3@carbon material, significantly reduced the BET surface area from 3036 m2 g-1 to 387 m2 g-1, but increased the average pore diameter up to 5.78 nm and disintegrated their octahedral structures to an irregular morphology of Fe-MOF (550), and modified the carbon matrix with trace oxygen and metal oxides.	Oxygen	394-400	delta/notch like EGF repeat containing	Homo sapiens	159-162
31679334-5	2019	Specifically, the hydrogen plasma engraved Co-MOF-74 shows enhanced catalytic activity of oxygen evolution reaction, which exhibits a low overpotential (337 mV at 15 mA cm-2), high turnover frequency (0.0219 s-1), and large mass activity (54.3 A g-1).	Oxygen	90-96	lysine acetyltransferase 8	Homo sapiens	43-52
30147267-9	2018	A hypoxic precondition (1% O2) in culture increases CXCR4 (p=0.000) and SDF-1 expression than normoxic conditions (p=0.000) (p&lt;0.05).	Oxygen	27-29	C-X-C motif chemokine ligand 12	Rattus norvegicus	72-77
29465224-6	2018	In addition, the obtained 3D hierarchical MnCo2O4 porous dumbbells also display good oxygen evolution reaction activity with an overpotential of 426 mV at a current density of 10 mA cm-2 and a Tafel slope of 93 mV dec-1.	Oxygen	85-91	deleted in esophageal cancer 1	Homo sapiens	214-219
31775033-7	2019	Conversely, Zc3h10 ablation in UCP1+ cells in mice impairs thermogenic capacity and lowers oxygen consumption, leading to weight gain.	Oxygen	91-97	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	31-35
29983448-6	2018	Moreover, the radical HCS is found to be more abundant than its oxygen analogue, HCO.	Oxygen	64-70	holocarboxylase synthetase	Homo sapiens	22-25
30147267-10	2018	Conclusion: Hypoxic preconditioning with 1% O2 increase CXCR4 and SDF1 expression.	Oxygen	44-46	C-X-C motif chemokine ligand 12	Rattus norvegicus	66-70
31885781-10	2019	In conclusion, HIF-1alpha, F2RL1, and PIK3CB may act as novel drivers for vitiligo, which are all closely associated with reactive oxygen species and possibly contribute to the activation and/or migration of melanocyte-specific CD8+ T cells in vitiligo.	Oxygen	131-137	F2R like trypsin receptor 1	Homo sapiens	27-32
29900471-3	2018	In this work, the complex (sub-)surface oxygen species on surface-selectively labelled gamma-Al2O3 were probed by 17O dynamic nuclear polarization surface-enhanced NMR spectroscopy (DNP-SENS).	Oxygen	40-46	potassium channel tetramerization domain containing 1	Homo sapiens	186-190
30966347-6	2018	From UL-94 and limited oxygen index (LOI) tests, PA6/ABPA/PMMT presented the best flame performance, with a UL-94 of V-0 and a LOI of 33%.	Oxygen	23-29	filamin C	Homo sapiens	53-57
31617511-5	2019	The characteristic feature of the space group P4mm (#99) model is atomic displacements in the [001] direction, which allows us to simulate the FEz displacements, whereas the P4 (#75) model besides FEz displacements permits oxygen octahedra antiphase rotations around the [001] direction and thus AFDz displacements.	Oxygen	223-229	FEZ family zinc finger 1	Homo sapiens	197-200
29900191-0	2018	Data on the role of iba57p in free Fe2+ release and O2 - generation in Saccharomyces cerevisiae.	Oxygen	52-54	Iba57p	Saccharomyces cerevisiae S288C	20-26
29462561-7	2018	It was observed that the edge groups contribute up to 51% of the total hydration-free energy and that the PMF indicates the tendency for spontaneous aggregation at all investigated concentrations, being lower the higher the concentration of oxygen.	Oxygen	241-247	proline rich protein BstNI subfamily 1	Homo sapiens	106-109
29911701-4	2018	Interestingly, it is found that Li1+xFe1-xPO4 cannot be delithiated completely and thus cannot achieve extra capacity by anionic redox activity, because the local oxygen-ion redox will cause the fracture of the rigid framework formed by phosphate tetrahedral polyanions.	Oxygen	163-169	exportin 4	Homo sapiens	41-45
31472109-2	2019	We show that mice deficient in their capacity to generate reactive oxygen by the NADPH oxidase 2 holoenzyme, an enzyme complex highly expressed in neutrophils and macrophages, have disrupted capacity to orchestrate signaling events that function in mucosal repair.	Oxygen	67-73	cytochrome b-245, beta polypeptide	Mus musculus	81-96
29168914-1	2018	Unprecedented scatter plots of calculated versus measured NMR 2,3 JCH coupling constants in six densely oxygen functionalized epoxides are found with some B3LYP protocols, an effect attributed to stereoelectronic effects.	Oxygen	104-110	joining chain of multimeric IgA and IgM	Homo sapiens	66-69
29092848-3	2018	The endothelin system has recently been demonstrated to regulate oxygen availability in the diabetic kidney via a pathway involving endothelin type A receptors (ETA-R).	Oxygen	65-71	endothelin receptor type A	Rattus norvegicus	132-159
29092848-3	2018	The endothelin system has recently been demonstrated to regulate oxygen availability in the diabetic kidney via a pathway involving endothelin type A receptors (ETA-R).	Oxygen	65-71	endothelin receptor type A	Rattus norvegicus	161-166
29092848-11	2018	In conclusion, increased ETB-R signaling in the diabetic kidney improves intrarenal tissue oxygenation due to increased oxygen delivery secondary to increased renal blood flow.	Oxygen	91-97	endothelin receptor type B	Rattus norvegicus	25-30
31439648-7	2019	Moreover, deletion of CCR2 inhibited STZ-induced apoptosis and the production of STZ-induced reactive oxygen species in the heart.	Oxygen	102-108	chemokine (C-C motif) receptor 2	Mus musculus	22-26
29516581-5	2018	Peer-reviewed Special Issues this year included contributions from the 12th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, Artificial Oxygen Carriers edited by Drs.	Oxygen	230-236	sushi repeat containing protein X-linked	Homo sapiens	256-259
29193870-5	2018	Deletion of arcA, whose gene product is a global transcriptional regulator, was the only modification among those evaluated that significantly decreased acetate under both transient and prolonged oxygen limitation.	Oxygen	196-202	arginine deiminase	Escherichia coli	12-16
31432395-12	2019	We also found an increase in the production of O2- and decreased expression of SOD1, Cx43, CAV2, and KLF4 in PASMC induced by miR-1, which may contribute to endothelial dysfunction.	Oxygen	47-50	microRNA 1	Rattus norvegicus	126-131
29311623-8	2018	Lastly, we show that transient exposure of wild-type MSCs to 21% oxygen upregulates p53 protein expression, resulting in increased mitochondrial ROS production and enhanced adipogenic differentiation at the expense of osteogenesis, and that treatment of cells with FGF2 mitigates these effects by inducing TWIST2.	Oxygen	65-71	fibroblast growth factor 2	Mus musculus	265-269
29311623-8	2018	Lastly, we show that transient exposure of wild-type MSCs to 21% oxygen upregulates p53 protein expression, resulting in increased mitochondrial ROS production and enhanced adipogenic differentiation at the expense of osteogenesis, and that treatment of cells with FGF2 mitigates these effects by inducing TWIST2.	Oxygen	65-71	twist basic helix-loop-helix transcription factor 2	Mus musculus	306-312
31451761-2	2019	We identified the bacterial light-oxygen-voltage (LOV) photoreceptor PAL that sequence-specifically binds short RNA stem loops with around 20 nM affinity in blue light and weaker than 1 microM in darkness.	Oxygen	34-40	SHC binding and spindle associated 1	Homo sapiens	69-72
31138730-0	2019	Impact of Home Oxygen Therapy on the Level of Physical Activities in Daily Life in Subjects With COPD.	Oxygen	15-21	COPD	Homo sapiens	97-101
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	angiopoietin 1	Homo sapiens	104-118
28714140-10	2018	Angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin-1 (Ang-1) were significantly increased by low-oxygen culture of hMSCs, which further stabilized and supported the maturation of microvessels.	Oxygen	163-169	angiopoietin 1	Homo sapiens	120-125
31138730-11	2019	CONCLUSIONS: Subjects with COPD using oxygen at home showed reduced level of PADL.	Oxygen	38-44	COPD	Homo sapiens	27-31
29118307-6	2018	Compared with the neutrophil elastase inhibitor group, the control group had significantly higher initial alveolar-arterial oxygen gradient and significantly lower initial ratio of partial pressure of arterial oxygen to fraction of inspired oxygen at the intensive care unit (ICU).	Oxygen	124-130	elastase, neutrophil expressed	Homo sapiens	18-37
31686456-6	2019	In multivariate analyses, oxygen desaturation index and JAG1 genotype independently predicted morning SBP (P=0.001, P=0.003, respectively) and DBP (P&lt;0.001, P=0.005, respectively), and evening SBP (P=0.019, P=0.048, respectively) and DBP (P=0.018, P=0.018, respectively).	Oxygen	26-32	selenium binding protein 1	Homo sapiens	102-105
29118307-6	2018	Compared with the neutrophil elastase inhibitor group, the control group had significantly higher initial alveolar-arterial oxygen gradient and significantly lower initial ratio of partial pressure of arterial oxygen to fraction of inspired oxygen at the intensive care unit (ICU).	Oxygen	210-216	elastase, neutrophil expressed	Homo sapiens	18-37
29118307-6	2018	Compared with the neutrophil elastase inhibitor group, the control group had significantly higher initial alveolar-arterial oxygen gradient and significantly lower initial ratio of partial pressure of arterial oxygen to fraction of inspired oxygen at the intensive care unit (ICU).	Oxygen	210-216	elastase, neutrophil expressed	Homo sapiens	18-37
31736992-6	2019	Under salt stress conditions, enhancement of endogenous PAs due to overexpression of the SAMDC gene and exogenous treatment with Spd considerably reduces the reactive oxygen species (ROS) accumulation in intra- and extracellular compartments.	Oxygen	167-173	S-adenosylmethionine decarboxylase proenzyme	Nicotiana tabacum	89-94
28994107-6	2018	Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts.	Oxygen	62-64	FAT atypical cadherin 1	Homo sapiens	104-108
31527314-5	2019	Myofibers isolated from Mss51-KO mice showed an increased oxygen consumption rate compared with WT controls, indicating an accelerated rate of skeletal muscle metabolism.	Oxygen	58-64	MSS51 mitochondrial translational activator	Mus musculus	24-29
29449612-1	2018	Ixr1 is a Saccharomyces cerevisiae HMGB protein that regulates the hypoxic regulon and also controls the expression of other genes involved in the oxidative stress response or re-adaptation of catabolic and anabolic fluxes when oxygen is limiting.	Oxygen	228-234	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	0-4
31490505-0	2019	Bimetallic MOF-templated synthesis of alloy nanoparticle-embedded porous carbons for oxygen evolution and reduction reactions.	Oxygen	85-91	lysine acetyltransferase 8	Homo sapiens	11-14
29229611-15	2018	CONCLUSIONS: In healing myocardial infarction, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional outcomes that may involve activation of an integrin/reactive oxygen axis.	Oxygen	197-203	SMAD family member 3	Mus musculus	103-108
31594343-3	2019	The activation energy (Ea) of Cr3+ oxidation determined by the Jander model was 2.7 +- 0.2 eV, which is in good correlation with the activation energy of innergrain oxygen diffusion in the YAG lattice.	Oxygen	165-171	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	30-33
30966217-4	2018	HA acts as a multidentate ligand using carboxylic and hydroxyl proton donor groups to link oxygen atoms in B-O-B bonds and borate-anions B-O(-): O-H   O, O-H   (-)O.	Oxygen	91-97	G protein-coupled receptor 15	Homo sapiens	107-112
31594343-4	2019	It is concluded that Cr3+ to Cr4+ transformation in YAG ceramics is limited by oxygen diffusion through the grain body.	Oxygen	79-85	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	21-24
29266417-0	2018	MOF-Derived Bifunctional Cu3 P Nanoparticles Coated by a N,P-Codoped Carbon Shell for Hydrogen Evolution and Oxygen Reduction.	Oxygen	109-115	lysine acetyltransferase 8	Homo sapiens	0-3
29101592-1	2018	Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters.	Oxygen	160-162	neuroglobin	Mus musculus	0-11
29101592-1	2018	Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters.	Oxygen	160-162	neuroglobin	Mus musculus	13-16
31594343-4	2019	It is concluded that Cr3+ to Cr4+ transformation in YAG ceramics is limited by oxygen diffusion through the grain body.	Oxygen	79-85	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	29-32
31408840-9	2019	The antagonistic effects of AR against rhTNF-alpha-induced cytotoxicity might be potentially attributed to the degeneration of reactive oxygen species and the increasing of mitochondrial membrane potential, along with the suppression of durative phosphorylation of c-Jun N-terminal kinase (JNK).	Oxygen	136-142	ferredoxin reductase	Mus musculus	28-30
29067740-8	2018	Intravitreal injected ASC SH-NOTCH2 in oxygen-induced retinopathy mouse eyes did not engraft in the preexisting retinal microvasculature.	Oxygen	39-45	notch 2	Mus musculus	29-35
31099025-5	2019	Moreover, PFB@PLLA loads high amount of oxygen and US-triggering PFB@PLLA reoxygenation effectively inhibits the expression of hypoxia-related proteins (HIF-1alpha and CAIX), reduces lactate secretion and glycolysis, which modulates hypoxic microenvironment and inhibits cancer cell migration and invasion in vitro.	Oxygen	40-46	carbonic anhydrase 9	Homo sapiens	168-172
31451430-10	2019	However, GiprBAT-/- mice exhibited higher body temperatures during an acute cold challenge and a lower respiratory exchange ratio and impaired lipid tolerance at 21  C. In contrast, body weight was lower and iBAT oxygen consumption was higher in HFD-fed mice housed at 4  C but not at 30  C. CONCLUSIONS: The BAT GIPR is linked to the control of metabolic gene expression, fuel utilization, and oxygen consumption.	Oxygen	213-219	solute carrier family 10, member 2	Mus musculus	208-212
29343643-7	2018	Furthermore, Cap15 does not produce hydrogen peroxide and is shown to directly incorporate a single O atom from O2 into the product CarU and thus is an authentic PLP-dependent monooxygenase.	Oxygen	112-114	pyridoxal phosphatase	Homo sapiens	162-165
30885648-7	2019	Furthermore, the docking results of 13a revealed that the oxygen atom at the position of C-3 connected to the heme of CYP17, which may be helpful for its satisfactory dual-target inhibition.	Oxygen	58-64	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	118-123
29581926-5	2018	While using morphine and oxygen is associated with risks such as higher mortality and increase in the size of the infarct, respectively, several available drugs such as fibrinolytics, anticoagulants, beta-blockers, renin-angiotensin-aldosterone system inhibitors, P2Y12 inhibitors, and statins are known to be useful to treat ACS.	Oxygen	25-31	purinergic receptor P2Y12	Homo sapiens	264-269
29950672-5	2018	Additionally, oxygen contamination within the Li2S-P2S5 leads initially to Li3PO4 phase segregation, and subsequently to Li2O formation.	Oxygen	14-20	ATP binding cassette subfamily A member 12	Homo sapiens	46-49
29896594-3	2018	The dimetallic phosphine-based Ag3 complex, having a high oxygen sensing ability, was employed as an efficient signal transducer in enzymatic reactions to recognize blood plasma glucose and urine glucose, which provided a wide linear response for a concentration range between 1.0 and 35 mM and a rapid response, with a limit of detection (LOD) of 0.09 mM for glucose.	Oxygen	58-64	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	31-34
31212267-5	2019	As for catalyst of oxygen evolution reaction, the reduced Co3O4 delivers a smaller potential of 1.55 V versus the reversible hydrogen electrode to realize a current density of 10 mA cm-2 and a lower Tafel slope of 71 mV dec-1 in alkaline solution, and these values are smaller than those of pristine Co3O4.	Oxygen	19-25	deleted in esophageal cancer 1	Homo sapiens	220-225
29376118-4	2018	Our modeling, paradoxically, reveals that micromolar levels of O2 in seawater enhance the preservation of large MIF-S signals, whereas concomitant ingrowth of sulfate expands the ranges in pyrite delta34S.	Oxygen	63-65	macrophage migration inhibitory factor	Homo sapiens	112-115
31558702-6	2019	Mechanistically, HMGB1 binding with TLR2 receptor functions in a paracrine manner to affect CD133- pancreatic cancer cells dedifferentiation via activating Hippo-YAP pathway and HIF-1alpha expression in oxygen independent manner in vitro and in vivo.	Oxygen	203-209	high mobility group box 1	Homo sapiens	17-22
29497482-12	2017	In MCF-7 cells, interleukin-8, angiogenin and vascular endothelial growth factor secretion was significantly increased by high fractional oxygen.	Oxygen	138-144	angiogenin	Homo sapiens	31-41
29870585-2	2018	Owing to the optimized surface configuration and altered electronic structure, the prepared catalyst displays a remarkable oxygen evolution reaction (OER) performance with low overpotential of 188 mV at 10 mA cm-2 in acidic electrolyte, an ultralow Tafel slope of 43.96 mV dec-1 , and excellent stability in durability testing for 10 000 cycles, and continuous testing of 8 h at a current density of 10 mA cm-2 .	Oxygen	123-129	deleted in esophageal cancer 1	Homo sapiens	273-278
31476275-3	2019	This as-developed metal-free amino-rich hierarchical-network carbon (amino-HNC) framework directly supported on carbon paper can catalyze OER at a quite low overpotential of 281 mV and a small Tafel slope of 96 mV dec-1 in an acid solution, and maintain ~98% of its initial catalytic activity after 100 h oxygen evolution operation.	Oxygen	305-311	deleted in esophageal cancer 1	Homo sapiens	214-219
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Oxygen	143-145	carbonic anhydrase 4	Homo sapiens	15-19
29196607-2	2018	phot2 comprises two BL-receiving light-oxygen-voltage-sensing domains (LOV1 and LOV2) and a kinase domain.	Oxygen	39-45	phototropin 2	Arabidopsis thaliana	0-5
31483596-3	2019	After pretreatment, the thickness of the interfacial layer between GaN films and the substrates decreases from 2.0 to 1.6 nm, and the oxygen impurity content at the GaN/Si (100) interface reduces from 34 to 12%.	Oxygen	134-140	gigaxonin	Homo sapiens	165-168
29246266-2	2018	We hypothesized that respiratory events and subsequent oxygen desaturation act as an important physiological trigger and may thus influence dream content in patients with a sleep-related breathing disorder.	Oxygen	55-61	potassium voltage-gated channel interacting protein 3	Homo sapiens	140-145
30002689-0	2018	MicroRNA-135b-5p prevents oxygen-glucose deprivation and reoxygenation-induced neuronal injury through regulation of the GSK-3beta/Nrf2/ARE signaling pathway.	Oxygen	26-32	glycogen synthase kinase 3 beta	Homo sapiens	121-130
31540488-2	2019	Exposure of the oxygen transport protein horse heart myoglobin (hhMb) to HOCl inhibits Iron III (Fe(III))-heme reduction by cytochrome b5 to oxygen-binding Iron II (Fe(II))Mb.	Oxygen	16-22	cytochrome b5 type A	Equus caballus	124-137
29602797-7	2018	Mass spectral analysis of CYP2J2 partially inactivated by EE showed two distinct protein masses in the deconvoluted spectrum that exhibited a mass difference of approximately 312 Da, which is equivalent to the sum of the mass of EE and one oxygen atom.	Oxygen	240-246	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	26-32
29893740-7	2018	In the oxidation stage, Mn(II) promotes the production of HO2 / O2 -, then HO2 / O2 - reacts with Fe(III) to accelerate the formation of Fe(II), and finally accelerates the production of HO .	Oxygen	64-66	heme oxygenase 2	Homo sapiens	58-61
28925400-2	2018	Although numerous potential substrates and functions of pVHL have been described over the past decade, the best-defined role of pVHL has remained as the negative regulator of the heterodimeric hypoxia-inducible factor (HIF) transcription factor via the oxygen-dependent ubiquitin-mediated degradation of HIF-alpha subunit.	Oxygen	253-259	von Hippel-Lindau tumor suppressor	Homo sapiens	128-132
29265811-3	2018	reveals that Al3+ ions diffuse into the spinel to form a layered Li(Alx,Mny)O2 structure in the outmost surface where Al3+ concentration is the highest.	Oxygen	76-78	hematopoietic SH2 domain containing	Homo sapiens	68-71
31540488-2	2019	Exposure of the oxygen transport protein horse heart myoglobin (hhMb) to HOCl inhibits Iron III (Fe(III))-heme reduction by cytochrome b5 to oxygen-binding Iron II (Fe(II))Mb.	Oxygen	141-147	cytochrome b5 type A	Equus caballus	124-137
29684281-7	2018	A mechanism for the hydrolysis of Gly-Gly by MOF-808 is proposed in which Gly-Gly binds to two Zr(IV) centers of the {Zr6O8} core via the oxygen atom of the amide group and the N-terminus.	Oxygen	138-144	lysine acetyltransferase 8	Homo sapiens	45-48
31540488-9	2019	Taken together, these data indicate oxidizing HOCl promotes Mb oxidation but not chlorination and that oxidized Mb shows altered Mb peroxidase-like activity and diminished rates of one-electron reduction by cytochrome b5 reductase, possibly affecting oxygen storage and transport however, Mb-catalase-like antioxidant activity remains unchanged.	Oxygen	251-257	cytochrome b5 type A	Equus caballus	207-220
31229876-7	2019	SAR analysis indicated, that an exchange of oxygen to selenium (7 vs. 22), and especially, to sulfur (7 vs. 19) was beneficial to increase both affinity and antagonistic action for 5-HT6R.	Oxygen	44-50	5-hydroxytryptamine receptor 6	Homo sapiens	181-187
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	24-26	deleted in esophageal cancer 1	Homo sapiens	186-191
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	78-84	deleted in esophageal cancer 1	Homo sapiens	186-191
29259115-6	2018	However, like its counterparts, our biological studies indicate that knockdown of MiNT leads to increased accumulation of mitochondrial labile iron, as well as increased mitochondrial reactive oxygen production.	Oxygen	193-199	spen family transcriptional repressor	Homo sapiens	82-86
29386891-2	2018	Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia.	Oxygen	10-16	COPD	Homo sapiens	68-72
31412728-6	2019	Cardiac-specific overexpression of PGC1alpha (PGC1alphaOE) promoted mitochondrial and cardiac function in 3-month-old WT mice but accelerated cardiac aging and significantly shortened life span in 12-month-old WT mice because of increased mitochondrial damage and reactive oxygen species insult.	Oxygen	273-279	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	35-44
29158339-7	2018	Finally, Ccr4 and Dhh1 associate with mRNAs whose abundance increases during nutrient starvation, and those that fluctuate during metabolic and oxygen consumption cycles, which explains the known genetic connections between these factors and nutrient utilization and stress pathways.	Oxygen	144-150	CCR4-NOT core exoribonuclease subunit CCR4	Saccharomyces cerevisiae S288C	9-13
30178315-8	2018	Angioplasticity is primarily regulated through the hypoxia inducible transcription factor, acting as a detector of the balance between oxygen delivery and energy demand at the level of the cell redox state, controlling vascular endothelial growth factor production which helps determine capillary density in consort with the cyclooxygenase-2/angiopoietin-2 pathway that controls endothelial cell junction mechanical stability.	Oxygen	135-141	angiopoietin 2	Homo sapiens	342-356
29748591-8	2018	Gain-of-function and loss-of-function assays showed that miR-3662 dampened glycolysis by reducing lactate production, glucose consumption, cellular glucose-6-phosphate level, ATP generation, and extracellular acidification rate, and increasing oxygen consumption rate in HCC cells after treatment with the hypoxia mimetic CoCl2.	Oxygen	244-250	microRNA 3662	Homo sapiens	57-65
29433031-1	2018	Both Cl- and base can affect PMS activation to produce reactive chlorine or oxygen species, but the overall effects of chloride on this emerging PMS/base technology in saline wastewater treatment are unknown.	Oxygen	76-82	proline rich protein BstNI subfamily 1	Homo sapiens	29-32
31412728-6	2019	Cardiac-specific overexpression of PGC1alpha (PGC1alphaOE) promoted mitochondrial and cardiac function in 3-month-old WT mice but accelerated cardiac aging and significantly shortened life span in 12-month-old WT mice because of increased mitochondrial damage and reactive oxygen species insult.	Oxygen	273-279	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	46-57
31551710-0	2019	Long Non-coding RNA TUG1 Sponges Mir-145a-5p to Regulate Microglial Polarization After Oxygen-Glucose Deprivation.	Oxygen	87-93	taurine up-regulated 1	Homo sapiens	20-24
29741264-6	2018	Secondary CE can also result from defects in the components of the oxygen-sensing pathway (PHD2, HIF2alpha and VHL).	Oxygen	67-73	von Hippel-Lindau tumor suppressor	Homo sapiens	111-114
29879425-9	2018	A five-day course of neuraminidase inhibitor was prescribed for all patients, as recommended by the WHO, but due to the complications, 73% of the patients required antibiotic therapy, and 61% oxygen therapy.	Oxygen	192-198	neuraminidase 1	Homo sapiens	21-34
31551710-0	2019	Long Non-coding RNA TUG1 Sponges Mir-145a-5p to Regulate Microglial Polarization After Oxygen-Glucose Deprivation.	Oxygen	87-93	MLX interacting protein	Homo sapiens	33-36
31500245-5	2019	Using a reporter construct containing the oxygen-dependent degradation (ODD) domain of HIF-1alpha and a fluorogenic proteasome substrate in combination with SHP-2 mutant constructs, we show that SHP-2 inhibits the 26S proteasome activity in endothelial cells under hypoxic conditions in vitro via Src kinase/p38 mitogen-activated protein kinase (MAPK) signalling.	Oxygen	42-48	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	195-200
29031855-0	2018	Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy.	Oxygen	92-98	furin (paired basic amino acid cleaving enzyme)	Mus musculus	0-5
29864887-4	2018	The DAC is kept under inert gas overpressure during the whole process, in order to avoid contamination from atmospheric O2, CO2, and H2O.	Oxygen	120-122	arylacetamide deacetylase	Homo sapiens	4-7
31564830-0	2019	Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling.	Oxygen	53-59	ryanodine receptor 2	Rattus norvegicus	175-179
29688629-5	2018	Accordingly, an optimal oxygen-doped NiCoP ( 0.98% oxygen) nanowire array is found to exhibit the remarkably low hydrogen evolution reaction (HER) overpotential of 44 mV to drive 10 mA cm-2 and a small Tafel slope of 38.6 mV dec-1 , and long-term stability of 30 h in an alkaline medium.	Oxygen	24-30	deleted in esophageal cancer 1	Homo sapiens	225-230
29688629-5	2018	Accordingly, an optimal oxygen-doped NiCoP ( 0.98% oxygen) nanowire array is found to exhibit the remarkably low hydrogen evolution reaction (HER) overpotential of 44 mV to drive 10 mA cm-2 and a small Tafel slope of 38.6 mV dec-1 , and long-term stability of 30 h in an alkaline medium.	Oxygen	51-57	deleted in esophageal cancer 1	Homo sapiens	225-230
29717803-3	2018	These tubular catalysts with both open ends deliver electrochemical active surface area (ECSA) of 91.43 m2 gpt-1 which results from multiple Pt atoms exposed on the inner and outer surfaces that doubled Pt atoms can participate in catalytic reactions, further with enhanced electrocatalytic performance for oxygen reduction reaction (ORR).	Oxygen	307-313	glutamic--pyruvic transaminase	Homo sapiens	107-112
29199847-2	2018	Here, we report a novel function for Wnt3a in macrophages, whose exposure to this ligand shifts them towards a pro-angiogenic phenotype capable, under oxygen and glucose deprivation, of inducing in vitro tubular pattern structures in endothelial cells resembling capillary-like vasculature.	Oxygen	151-157	Wnt family member 3A	Homo sapiens	37-42
29199847-4	2018	This work provides a new link between Wnt3a and macrophage-mediated angiogenesis under glucose and oxygen deprivation in vitro, which are worth further investigation in pathological conditions including stroke, where the stimulation of the angiogenic process might help to recovery after tissue injury Impact statement This work provides a new link between Wnt3a and macrophage-mediated angiogenesis under glucose and oxygen deprivation in vitro.	Oxygen	99-105	Wnt family member 3A	Homo sapiens	38-43
29199847-4	2018	This work provides a new link between Wnt3a and macrophage-mediated angiogenesis under glucose and oxygen deprivation in vitro, which are worth further investigation in pathological conditions including stroke, where the stimulation of the angiogenic process might help to recovery after tissue injury Impact statement This work provides a new link between Wnt3a and macrophage-mediated angiogenesis under glucose and oxygen deprivation in vitro.	Oxygen	418-424	Wnt family member 3A	Homo sapiens	38-43
29199847-5	2018	Our results reveal how Wnt3a shifts macrophages towards a pro-angiogenic phenotype, which is able-in absence of both glucose and oxygen-of inducing angiogenesis in vitro, thus pointing to a synergy between the activation of the pathway and the hypoxia scenario.	Oxygen	129-135	Wnt family member 3A	Homo sapiens	23-28
29197801-7	2018	The enhanced generation of reactive oxygen intermediates and nitric oxide by macrophages from mice treated with buprenorphine, oxycodone or morphine was also shown, along with increased release of IL-6, TNFalpha and TGFbeta.	Oxygen	36-42	transforming growth factor, beta 1	Mus musculus	216-223
29658552-0	2018	Exfoliation of ultrathin FePS3 layers as a promising electrocatalyst for the oxygen evolution reaction.	Oxygen	77-83	sodium voltage-gated channel alpha subunit 11	Homo sapiens	25-30
29658552-1	2018	Few-layer ternary FePS3 nanosheets, prepared via chemical vapor transport synthesis and ball-milling exfoliation, exhibit excellent electrocatalytic performance for the oxygen evolution reaction in an alkaline medium.	Oxygen	169-175	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-23
31426226-1	2019	This study examines how dissolved oxygen (DO) responds to tropical cyclones (TCs) "Wind Pump" in a pre-existing cyclonic and an anticyclonic eddy over the Bay of Bengal (BoB) based on Argo and satellite data.	Oxygen	34-40	G protein-coupled receptor 15	Homo sapiens	170-173
28960009-2	2018	Four H-abstraction paths and two kinds of products, among which the paths for HOCl + O2 formation are dominant, have been found for the HO2 + ClO reaction without water.	Oxygen	85-87	heme oxygenase 2	Homo sapiens	136-139
29330785-3	2018	The hypoxia-inducible factor (HIF) prolyl hydroxylases 1-3 (PHD1-3) and the asparagine hydroxylase factor-inhibiting HIF (FIH) are the primary cellular oxygen sensors, which confer cellular oxygen-dependent sensitivity upon HIF as well as other hypoxia-sensitive pathways, such as nuclear factor kappaB (NF-kappaB).	Oxygen	152-158	egl-9 family hypoxia inducible factor 2	Homo sapiens	35-66
29330785-3	2018	The hypoxia-inducible factor (HIF) prolyl hydroxylases 1-3 (PHD1-3) and the asparagine hydroxylase factor-inhibiting HIF (FIH) are the primary cellular oxygen sensors, which confer cellular oxygen-dependent sensitivity upon HIF as well as other hypoxia-sensitive pathways, such as nuclear factor kappaB (NF-kappaB).	Oxygen	190-196	egl-9 family hypoxia inducible factor 2	Homo sapiens	35-66
31254733-4	2019	Here we demonstrate that SLC4A11 is localized to the inner mitochondrial membrane of CE and SLC4A11 transfected PS120 fibroblasts, where it acts as an NH3-sensitive mitochondrial uncoupler that enhances glutamine-dependent oxygen consumption, electron transport chain activity, and ATP levels by suppressing damaging Reactive Oxygen Species (ROS) production.	Oxygen	223-229	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	25-32
29024093-4	2017	For CmO2+ , and AnO2+ beyond EsO2+ , the most stable structure has side-on bonded eta2 -(O2 ), as AnIII peroxides for An=Cm and Lr, and as AnII superoxides for An=Fm, Md, and No.	Oxygen	6-8	DNA polymerase iota	Homo sapiens	82-86
29417107-5	2018	Indeed, the fast HO2  formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2  formation timescale in cyclohexane oxidation is shown to be linked to the sequential  R + O2   ROO    alkene + HO2  pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1).	Oxygen	18-20	heme oxygenase 2	Homo sapiens	154-157
29417107-5	2018	Indeed, the fast HO2  formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2  formation timescale in cyclohexane oxidation is shown to be linked to the sequential  R + O2   ROO    alkene + HO2  pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1).	Oxygen	18-20	heme oxygenase 2	Homo sapiens	154-157
29417107-5	2018	Indeed, the fast HO2  formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2  formation timescale in cyclohexane oxidation is shown to be linked to the sequential  R + O2   ROO    alkene + HO2  pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1).	Oxygen	98-100	heme oxygenase 2	Homo sapiens	17-20
31295386-5	2019	The obtained hematite particles exhibit good catalytic performance in the oxygen evolution reaction (OER), affording a current density of 10 mA cm-2 with an overpotential of 370 mV, a small Tafel slope of 65 mV dec-1 , and good stability in alkaline electrolyte.	Oxygen	74-80	deleted in esophageal cancer 1	Homo sapiens	211-216
29417107-5	2018	Indeed, the fast HO2  formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2  formation timescale in cyclohexane oxidation is shown to be linked to the sequential  R + O2   ROO    alkene + HO2  pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1).	Oxygen	98-100	heme oxygenase 2	Homo sapiens	154-157
29417107-5	2018	Indeed, the fast HO2  formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2  formation timescale in cyclohexane oxidation is shown to be linked to the sequential  R + O2   ROO    alkene + HO2  pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1).	Oxygen	98-100	heme oxygenase 2	Homo sapiens	154-157
29664049-12	2018	In early PD patients, elevated serum CysC levels were positively correlated with oxygen desaturation index (r = 0.223, P = 0.021), percentage of time spent at oxygen saturation (SaO2) <90% (r = 0.644, P < 0.001), arousal with respiratory event during sleep (r = 0.247, P = 0.013).	Oxygen	81-87	cystatin C	Homo sapiens	37-41
29664049-12	2018	In early PD patients, elevated serum CysC levels were positively correlated with oxygen desaturation index (r = 0.223, P = 0.021), percentage of time spent at oxygen saturation (SaO2) <90% (r = 0.644, P < 0.001), arousal with respiratory event during sleep (r = 0.247, P = 0.013).	Oxygen	159-165	cystatin C	Homo sapiens	37-41
29664049-15	2018	PD patients with elevated serum CysC levels had more respiratory events and more severe oxygen desaturation.	Oxygen	88-94	cystatin C	Homo sapiens	32-36
28269997-6	2017	Utilizing an in vitro model of IPC, we found that PGC-1alpha expression was downregulated in hepatic cells cultured at 1% O2; whereas it was induced after reoxygenation (3% O2), and it was responsible for the recovery of antioxidant gene expression after the ischemic period.	Oxygen	122-124	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	50-60
28269997-6	2017	Utilizing an in vitro model of IPC, we found that PGC-1alpha expression was downregulated in hepatic cells cultured at 1% O2; whereas it was induced after reoxygenation (3% O2), and it was responsible for the recovery of antioxidant gene expression after the ischemic period.	Oxygen	173-175	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	50-60
27832523-1	2017	Relative 17beta-estradiol (E2) deprivation and excessive production of mitochondrial oxygen free radicals (OFRs) with a high amount of Ca2+ influx TRPA1, TRPM2, and TRPV1 activity is one of the main causes of neurodegenerative disease in postmenopausal women.	Oxygen	85-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	165-170
29168506-6	2017	NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage.	Oxygen	144-150	NFS1 cysteine desulfurase	Homo sapiens	0-4
29679980-7	2018	Analogously, 5% O2 decreased the ratio of Oct4-positive cells in fertilized blastocysts, whereas increased that in parthenogenetic blastocysts.	Oxygen	16-18	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	42-46
31375625-1	2019	Despite the discovery of the oxygen-sensitive regulation of HIFalpha by the von Hippel-Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown.	Oxygen	29-35	von Hippel-Lindau tumor suppressor	Homo sapiens	76-93
29442304-5	2018	Ti/SnO2-Sb-Pd-500 achieved the highest electrochemical capacity with the highest levels of adsorbed oxygen Oads/ET (27.11%) and lattice oxygen Olat/ET (29.69%).	Oxygen	100-106	strawberry notch homolog 1	Homo sapiens	3-6
29442304-5	2018	Ti/SnO2-Sb-Pd-500 achieved the highest electrochemical capacity with the highest levels of adsorbed oxygen Oads/ET (27.11%) and lattice oxygen Olat/ET (29.69%).	Oxygen	136-142	strawberry notch homolog 1	Homo sapiens	3-6
28951213-1	2017	Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules.	Oxygen	97-103	neuroglobin	Mus musculus	0-11
28951213-1	2017	Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules.	Oxygen	97-103	neuroglobin	Mus musculus	13-16
31375625-1	2019	Despite the discovery of the oxygen-sensitive regulation of HIFalpha by the von Hippel-Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown.	Oxygen	29-35	von Hippel-Lindau tumor suppressor	Homo sapiens	95-98
29108649-5	2017	We propose that these cavities could store oxygen and allow its relay in the heme proximity, which could correspond to NO location in the nitrite-reductase function of Ngb.	Oxygen	43-49	neuroglobin	Mus musculus	168-171
31375625-4	2019	Here, we identified an oxygen-sensitive function of VHL that is abolished by VHL type 2C mutations.	Oxygen	23-29	von Hippel-Lindau tumor suppressor	Homo sapiens	52-55
31375625-4	2019	Here, we identified an oxygen-sensitive function of VHL that is abolished by VHL type 2C mutations.	Oxygen	23-29	von Hippel-Lindau tumor suppressor	Homo sapiens	77-80
29628892-5	2018	The use of module oxygenation at an altitude of 5,050 m, simulating an altitude of 2,900 m, increased oxygen saturation from 84 +- 0.8 to 91 +- 0.8% (p &lt; 0.00001), decreased heart rate from 90 +- 8 to 77 +- 12 bpm (p &lt; 0.01) and DAP from 96 +- 3 to 87 +- 5 mmHg (p &lt; 0.01).	Oxygen	18-24	death associated protein	Homo sapiens	235-238
31430934-2	2019	The optimal ratio of FeCl3/EDA was found to be close to 1/3 under the consideration of the electrocatalytic performance, such as better oxygen reduction reaction (ORR) and higher power density.	Oxygen	136-142	ectodysplasin A	Homo sapiens	27-30
29493683-10	2018	The process involves first the formation of a coordinatively unsaturated site (CUS) and subsequently the binding of O2 to form superoxo and then peroxo eta2-O2 adducts.	Oxygen	116-118	DNA polymerase iota	Homo sapiens	152-156
29493683-10	2018	The process involves first the formation of a coordinatively unsaturated site (CUS) and subsequently the binding of O2 to form superoxo and then peroxo eta2-O2 adducts.	Oxygen	157-159	DNA polymerase iota	Homo sapiens	152-156
29046497-7	2017	Hypoxia (3% O2) increased GLUT1 mRNA expression in early luteal cells, but not in mid luteal cells.	Oxygen	12-14	solute carrier family 2 member 1	Bos taurus	26-31
31391167-5	2019	Genetic ablation of Nix impairs mitochondrial quality, platelet activation, and FeCl3-induced carotid arterial thrombosis without affecting the expression of platelet glycoproteins (GPs) such as GPIb, GPVI, and alphaIIbbeta3 Metabolic analysis revealed decreased mitochondrial membrane potential, enhanced mitochondrial reactive oxygen species level, diminished oxygen consumption rate, and compromised adenosine triphosphate production in Nix -/- platelets.	Oxygen	329-335	BCL2/adenovirus E1B interacting protein 3-like	Mus musculus	20-23
28843827-0	2017	PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.	Oxygen	34-40	protein tyrosine phosphatase, non-receptor type 21	Rattus norvegicus	0-6
28843827-0	2017	PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.	Oxygen	34-40	cyclin-dependent kinase 5	Rattus norvegicus	75-79
28843827-0	2017	PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.	Oxygen	34-40	mitogen activated protein kinase 3	Rattus norvegicus	88-94
29343498-5	2018	Consistent with these observations, GPR120 deficiency reduced expression of genes involved in nutrient handling in BAT Stimulation of brown adipocytes in vitro with TUG-891 acutely induced O2 consumption, through GPR120-dependent and GPR120-independent mechanisms.	Oxygen	189-191	free fatty acid receptor 4	Homo sapiens	36-42
31391167-5	2019	Genetic ablation of Nix impairs mitochondrial quality, platelet activation, and FeCl3-induced carotid arterial thrombosis without affecting the expression of platelet glycoproteins (GPs) such as GPIb, GPVI, and alphaIIbbeta3 Metabolic analysis revealed decreased mitochondrial membrane potential, enhanced mitochondrial reactive oxygen species level, diminished oxygen consumption rate, and compromised adenosine triphosphate production in Nix -/- platelets.	Oxygen	362-368	BCL2/adenovirus E1B interacting protein 3-like	Mus musculus	20-23
29475915-5	2018	ROCK1/2 levels were correlated with blood triglyceride, visceral adiposity index, minimum oxygen saturation, C-reactive protein concentration, lymphocyte levels and sleep efficiency.	Oxygen	90-96	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	0-5
29235039-3	2018	By placing the lamp near a nanoESI emitter that partially transmits 185 nm ultraviolet (UV) emission from the lamp, dissolved dioxygen in the spray solution was converted into ozone, which subsequently cleaved the double bonds within fatty acyls of lipids.	Oxygen	126-134	lysosomal associated membrane protein 3	Homo sapiens	15-19
29235039-3	2018	By placing the lamp near a nanoESI emitter that partially transmits 185 nm ultraviolet (UV) emission from the lamp, dissolved dioxygen in the spray solution was converted into ozone, which subsequently cleaved the double bonds within fatty acyls of lipids.	Oxygen	126-134	lysosomal associated membrane protein 3	Homo sapiens	110-114
28899780-2	2017	Some cellular sources of reactive oxygen species, like NADPH oxidase 4, are sensitive to oxygen levels in the range between "normal" physiological (typically 1-5%) and standard cell culture (up to 18%).	Oxygen	34-40	NADPH oxidase 4	Homo sapiens	55-70
28899780-7	2017	These data indicate that oxygen levels experienced by cells in culture influence hydrogen peroxide production via NADPH oxidase 1/4, highlighting the importance of regulating oxygen levels in culture near physiological values.	Oxygen	25-31	NADPH oxidase 1	Homo sapiens	114-129
28899780-7	2017	These data indicate that oxygen levels experienced by cells in culture influence hydrogen peroxide production via NADPH oxidase 1/4, highlighting the importance of regulating oxygen levels in culture near physiological values.	Oxygen	175-181	NADPH oxidase 1	Homo sapiens	114-129
29100094-6	2017	SLC25A24-mutant fibroblasts and cells expressing p.Arg217Cys or p.Arg217His variants showed altered mitochondrial morphology, a decreased proliferation rate, increased mitochondrial membrane potential, and decreased ATP-linked mitochondrial oxygen consumption.	Oxygen	241-247	solute carrier family 25 member 24	Homo sapiens	0-8
31090983-0	2019	Oxygen-Bridged Ga2 (Et)3 (OTeF5 )3 and the Weakly Coordinating Anions [Ga(Et)(OTeF5 )3 ]- and [Ga(OTeF5 )4 ].	Oxygen	0-6	electron transfer flavoprotein subunit alpha	Homo sapiens	15-18
28447229-7	2017	In a mouse model of oxygen-induced retinopathy (OIR), which is a surrogate model of ROP and PDR, we demonstrated that intravitreal injection of anti-pleiotrophin antibody prevented OIR-induced pathological retinal neovascularization and aberrant vessel tufts.	Oxygen	20-26	pleiotrophin	Mus musculus	149-161
29452577-12	2018	Poldip2 expression was upregulated in astrocytes exposed to oxygen and glucose deprivation (OGD) and siRNA-mediated downregulation of Poldip2 abrogated OGD-induced IL-6 and TNF-alpha expression.	Oxygen	60-66	polymerase (DNA-directed), delta interacting protein 2	Mus musculus	0-7
31155493-5	2019	Furthermore, organoids from patients with genetic dysfunction of lysosomal acid lipase phenocopied severe steatohepatitis, rescued by FXR agonism-mediated reactive oxygen species suppression.	Oxygen	164-170	lipase A, lysosomal acid type	Homo sapiens	65-86
29414908-2	2018	For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was proposed; the resulting ferrous-peroxynitrate species was not detected, but its decay product, the high-valent ferryl form, was demonstrated in stopped-flow experiments.	Oxygen	74-80	myoglobin	Bos taurus	4-13
28802561-9	2017	Furthermore, elafin prevented the elastin degradation, neutrophil influx, activation of TGF-beta1 and apoptosis caused by 85% O2 exposure.	Oxygen	126-128	peptidase inhibitor 3	Homo sapiens	13-19
28802561-11	2017	Elafin prevents these changes by inhibiting elastase and the TGF-beta1 signalling cascade and may be a new therapeutic target for preventing O2-induced lung injury in neonates.	Oxygen	141-143	peptidase inhibitor 3	Homo sapiens	0-6
31155493-5	2019	Furthermore, organoids from patients with genetic dysfunction of lysosomal acid lipase phenocopied severe steatohepatitis, rescued by FXR agonism-mediated reactive oxygen species suppression.	Oxygen	164-170	nuclear receptor subfamily 1 group H member 4	Homo sapiens	134-137
28856381-6	2018	Consistent with its role in pathological angiogenesis, Scg3-neutralizing antibodies alleviate retinal vascular leakage in mouse models of diabetic retinopathy and retinal neovascularization in oxygen-induced retinopathy mice.	Oxygen	193-199	secretogranin III	Mus musculus	55-59
31070932-9	2019	These data identify a key role for AMPK-NKCC1 interaction as a point of convergence for suppression of colonic epithelial ion transport by inflammatory reactive oxygen species.NEW & NOTEWORTHY H2O2 inhibition of intestinal epithelial Ca2+-dependent Cl- secretion involves recruitment of AMP-activated protein kinase (AMPK) downstream of ERK and phosphatidylinositol 3-kinase signaling pathways, physical interaction of AMPK with the Na+-K+-2Cl- cotransporter NKCC1, and AMPK-dependent suppression of NKCC1-mediated electrolyte influx without causing NKCC1 internalization.	Oxygen	161-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	35-39
29181441-10	2017	Conclusion: The severity of ROP was associated with earlier gestational age, lower birth weight, and oxygen supplementation.	Oxygen	101-107	opsin 1, long wave sensitive	Homo sapiens	28-31
30644010-0	2019	Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety.	Oxygen	34-40	secretogranin III	Mus musculus	5-22
29123987-5	2017	We demonstrated that the introduction of JDP2 leads to upregulation of p16Ink4a and Arf and decreases cell proliferation in the presence of environmental (20% O2), but not in low (3% O2) oxygen.	Oxygen	187-193	Jun dimerization protein 2	Mus musculus	41-45
29190983-8	2017	In addition, the decreased autophagy induced by p62 overexpression increased Nrf2/ARE activity and the oxygen consumption rate and decreased on formation of reactive oxygen species.	Oxygen	103-109	sequestosome 1	Mus musculus	48-51
29185100-0	2018	Spatial distribution of CD115+ and CD11b+ cells and their temporal activation during oxygen-induced retinopathy in mice.	Oxygen	85-91	colony stimulating factor 1 receptor	Homo sapiens	24-29
28961371-3	2018	METHODS AND RESULTS: The objective of this study is to investigate the effect of physiologically relevant O2 concentrations of the gut on the production and secretion of the satiety hormone, glucagon-like peptide 1 (GLP-1), from the murine enteroendocrine cell line, secretin tumor cell line (STC-1), in response to dairy macronutrients as they transit the gut.	Oxygen	106-108	glucagon	Mus musculus	191-214
28961371-3	2018	METHODS AND RESULTS: The objective of this study is to investigate the effect of physiologically relevant O2 concentrations of the gut on the production and secretion of the satiety hormone, glucagon-like peptide 1 (GLP-1), from the murine enteroendocrine cell line, secretin tumor cell line (STC-1), in response to dairy macronutrients as they transit the gut.	Oxygen	106-108	glucagon	Mus musculus	216-221
30644010-4	2019	Secretogranin III (Scg3) was recently discovered as a highly disease-restricted angiogenic factor, and a Scg3-neutralizing monoclonal antibody (mAb) was reported with high efficacy to alleviate oxygen-induced retinopathy (OIR) in mice, a surrogate model of ROP.	Oxygen	194-200	secretogranin III	Mus musculus	0-17
28961371-3	2018	METHODS AND RESULTS: The objective of this study is to investigate the effect of physiologically relevant O2 concentrations of the gut on the production and secretion of the satiety hormone, glucagon-like peptide 1 (GLP-1), from the murine enteroendocrine cell line, secretin tumor cell line (STC-1), in response to dairy macronutrients as they transit the gut.	Oxygen	106-108	stanniocalcin 1	Mus musculus	293-298
28961371-4	2018	GLP-1 exocytosis from STC-1 cells is influenced by both oxygen concentration and by individual macronutrients.	Oxygen	56-62	glucagon	Mus musculus	0-5
28961371-4	2018	GLP-1 exocytosis from STC-1 cells is influenced by both oxygen concentration and by individual macronutrients.	Oxygen	56-62	stanniocalcin 1	Mus musculus	22-27
28961371-5	2018	At low oxygen, STC-1 cell viability is significantly improved for all macronutrient stimulations and cyclic adenosine monophosphate levels are dampened.	Oxygen	7-13	stanniocalcin 1	Mus musculus	15-20
28961371-6	2018	GLP-1 secretion from STC-1 cells is influenced by both the phase of yogurt digestion and corresponding O2 concentration.	Oxygen	103-105	glucagon	Mus musculus	0-5
28961371-6	2018	GLP-1 secretion from STC-1 cells is influenced by both the phase of yogurt digestion and corresponding O2 concentration.	Oxygen	103-105	stanniocalcin 1	Mus musculus	21-26
28961371-7	2018	Atmospheric oxygen at 4.5% combined with upper gastric digesta, which simulates ileum conditions, yields the highest GLP-1 response.	Oxygen	12-18	glucagon	Mus musculus	117-122
29062875-1	2017	The data presented in this article are related to the research paper entitled "Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia" (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR).	Oxygen	134-140	norrin cystine knot growth factor NDP	Homo sapiens	79-85
29062875-1	2017	The data presented in this article are related to the research paper entitled "Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia" (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR).	Oxygen	362-368	norrin cystine knot growth factor NDP	Homo sapiens	79-85
29062875-1	2017	The data presented in this article are related to the research paper entitled "Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia" (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR).	Oxygen	362-368	norrin cystine knot growth factor NDP	Homo sapiens	250-256
29085625-5	2017	The dioxygen-dependent cleavage of the C6 and C1 bond in myo-Inositol is achieved by utilizing the Fe2+/Fe3+ binuclear iron center of MIOX.	Oxygen	4-12	myo-inositol oxygenase	Homo sapiens	134-138
30644010-4	2019	Secretogranin III (Scg3) was recently discovered as a highly disease-restricted angiogenic factor, and a Scg3-neutralizing monoclonal antibody (mAb) was reported with high efficacy to alleviate oxygen-induced retinopathy (OIR) in mice, a surrogate model of ROP.	Oxygen	194-200	secretogranin III	Mus musculus	19-23
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	microRNA 210	Homo sapiens	97-104
30644010-4	2019	Secretogranin III (Scg3) was recently discovered as a highly disease-restricted angiogenic factor, and a Scg3-neutralizing monoclonal antibody (mAb) was reported with high efficacy to alleviate oxygen-induced retinopathy (OIR) in mice, a surrogate model of ROP.	Oxygen	194-200	secretogranin III	Mus musculus	105-109
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	microRNA 210	Homo sapiens	130-137
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	microRNA 210	Homo sapiens	130-137
31062423-9	2019	Upregulation of miR-202-5p or downregulation of Trpv2 significantly reduced the serum concentration of myocardial enzymes, as well as cardiomyocyte-produced reactive oxygen species, but inhibition of miR-202-5p or overexpression of Trpv2 brought the worsening situation for these indicators.	Oxygen	166-172	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	48-53
29337924-4	2018	The K1 and K2 in dry and wet atmospheres at 350  C were increased by humid aging at 580  C, indicating an increase in the adsorption amount of both O- and O2-.	Oxygen	155-157	keratin 1	Homo sapiens	4-13
28988979-8	2017	IRX3 knockdown remarkably inhibited UCP1 expression in induced mouse and human beige adipocytes, and also repressed the uncoupled oxygen consumption rate.	Oxygen	130-136	Iroquois related homeobox 3	Mus musculus	0-4
29078966-1	2017	OBJECTIVE: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag reflex, regulating pulse rates and oxygen saturation, thereby reducing the anxiety levels.	Oxygen	150-156	proprotein convertase subtilisin/kexin type 5	Homo sapiens	74-77
31100427-3	2019	We hypothesize that AZD2014, a novel mTORC1/2 inhibitor, may protect neurons following oxygen and glucose deprivation (OGD).	Oxygen	87-93	CREB regulated transcription coactivator 2	Mus musculus	37-45
28739822-7	2017	HILPDA-knockout animals are viable and fertile, but show reduced ambulatory activity and oxygen consumption at regular housing conditions.	Oxygen	89-95	hypoxia inducible lipid droplet associated	Mus musculus	0-6
29050872-3	2018	In this study, we demonstrate for the first time that endogenous mesencephalic astrocyte-derived neurotrophic factor (MANF) protects NSCs against oxygen-glucose-deprivation-induced injury and has a crucial role in regulating NPC migration.	Oxygen	146-152	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	65-116
29050872-3	2018	In this study, we demonstrate for the first time that endogenous mesencephalic astrocyte-derived neurotrophic factor (MANF) protects NSCs against oxygen-glucose-deprivation-induced injury and has a crucial role in regulating NPC migration.	Oxygen	146-152	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	118-122
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	73-79	Wnt family member 2	Homo sapiens	218-221
30110696-1	2018	BACKGROUND/AIMS: alphaB -crystallin (alphaBC) belongs to the family of small heat shock proteins that are necessary for maintaining oxygen homeostasis.	Oxygen	132-138	crystallin, alpha B	Mus musculus	17-35
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	81-83	Wnt family member 2	Homo sapiens	218-221
28378505-9	2017	Furthermore, mice with a specific deletion of Prlr in Rip-Cre neurones had lower body weights, increased oxygen consumption, increased running wheel activity and numerous cells in the arcuate nucleus had positive GFP staining indicating deletion of Prlr from Rip-Cre neurones.	Oxygen	105-111	prolactin receptor	Mus musculus	46-50
27734335-3	2017	Therefore, we analyzed the expression and location of DSCR1 in the retina of neonatal mice with oxygen-induced retinopathy (OIR), and studied its effects on angiogenesis.	Oxygen	96-102	regulator of calcineurin 1	Mus musculus	54-59
28165799-14	2018	However, transcription of VEGF and ANG-1 was significantly higher at 2% oxygen than at 21% O2.	Oxygen	72-78	angiopoietin 1	Homo sapiens	35-40
28165799-14	2018	However, transcription of VEGF and ANG-1 was significantly higher at 2% oxygen than at 21% O2.	Oxygen	91-93	angiopoietin 1	Homo sapiens	35-40
28165799-15	2018	The optimum oxygen range at which hMSCs proliferated rapidly and angiogenic factors ANG-1 and VEGF simultaneously came to expression was from 1 to 2% oxygen.	Oxygen	12-18	angiopoietin 1	Homo sapiens	84-89
28165799-15	2018	The optimum oxygen range at which hMSCs proliferated rapidly and angiogenic factors ANG-1 and VEGF simultaneously came to expression was from 1 to 2% oxygen.	Oxygen	150-156	angiopoietin 1	Homo sapiens	84-89
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	Wnt family member 2	Homo sapiens	218-221
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	Wnt family member 2	Homo sapiens	218-221
30411685-5	2018	In normoxia condition HIF is inactivated by prolyl hydroxylase enzymes (EGLN 1-3, also known as PHD 1-3) using oxygen as a substrate.	Oxygen	111-117	egl-9 family hypoxia inducible factor 2	Homo sapiens	96-101
31229404-4	2019	In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation.	Oxygen	132-134	Wnt family member 2	Homo sapiens	218-221
28438707-8	2017	When trials were repeated in prime-probe pairs of the experimental condition, we detected improvements in performance accompanied by a significant suppression of blood oxygen-level dependent (BOLD) responses in: left SMg extending into and along the length of the intraparietal sulcus (IPS), right IPS, bilateral caudal superior parietal lobule (cSPL), dorsal premotor cortex (dPMC), pre-SMA, and in the lateral cerebellum.	Oxygen	168-174	survival of motor neuron 1, telomeric	Homo sapiens	388-391
31229404-5	2019	Together, these data identify a novel oxygen-dependent signaling axis that links IRP-dependent iron homeostasis with the Fe-S cluster assembly machinery.	Oxygen	38-44	Wnt family member 2	Homo sapiens	81-84
31257865-10	2019	We determined the P50 for oxygen to be 0.5 Torr for cytoglobin 1 and 4.4 Torr for cytoglobin 2 at 25  C. Thus, even at low oxygen tensions, the reduced cytoglobins may exist in a predominant oxygen-bound form.	Oxygen	26-32	cytoglobin 1	Danio rerio	52-64
28674755-10	2017	Structural models of FaNaC made by homology modeling showed that the distance between oxygen atoms of D552 and D556 on the adjacent subunits is close enough to coordinate Ca2+ in the nonconducting desensitized channel but not in the open channel.	Oxygen	86-92	carbonic anhydrase 2 L homeolog	Xenopus laevis	171-174
28674755-11	2017	The results suggest that Ca2+ coordination between oxygen atoms of D552 and D556 disturbs the opening transition as well as the desensitization of FaNaC.	Oxygen	51-57	carbonic anhydrase 2 L homeolog	Xenopus laevis	25-28
29121446-1	2018	von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1alpha in an oxygen-dependent manner.	Oxygen	131-137	von Hippel-Lindau tumor suppressor	Homo sapiens	69-73
32923966-0	2019	GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species.	Oxygen	101-107	endothelin receptor type A	Homo sapiens	0-4
29115559-5	2018	Expression levels of SUMO1 and SUMO2/3 proteins in the normoxia group were significantly lower than those in the medium- or high-oxygen groups (P&lt;0.01), but were comparable to those in the low-oxygen group.	Oxygen	129-135	small ubiquitin like modifier 1	Homo sapiens	21-26
29115559-5	2018	Expression levels of SUMO1 and SUMO2/3 proteins in the normoxia group were significantly lower than those in the medium- or high-oxygen groups (P&lt;0.01), but were comparable to those in the low-oxygen group.	Oxygen	196-202	small ubiquitin like modifier 1	Homo sapiens	21-26
29115559-8	2018	Supplemental oxygen with FiO2&gt;=30% was associated with upregulation of SUMO1 and SUMO2/3 expression and downregulation of SIRT1 expression.	Oxygen	13-19	small ubiquitin like modifier 1	Homo sapiens	74-79
29158829-5	2017	CA-IX confers cancer cell survival under low oxygen tension, and is associated with increased propensity for metastasis.	Oxygen	45-51	carbonic anhydrase 9	Homo sapiens	0-5
31215575-0	2019	A cobalt metal-organic framework (Co-MOF): a bi-functional electro active material for the oxygen evolution and reduction reaction.	Oxygen	91-97	lysine acetyltransferase 8	Homo sapiens	37-40
31215575-3	2019	In this study, we presented the synthesis of a Co-containing metal-organic framework (Co-MOF) and explored its electrocatalytic application towards the oxygen electrocatalysis (i.e. the oxygen reduction reaction and oxygen evolution reaction).	Oxygen	152-158	lysine acetyltransferase 8	Homo sapiens	89-92
28832142-1	2017	Reaction species were studied by multiplexed photoionization mass spectrometry at 550 and 650 K. The oxygen addition pathway is favored in this reaction, forming four triplet diradicals that undergo intersystem crossing into singlet epoxide species that lead to the formation of products at m/z 30 (formaldehyde), 42 (propene), 54 (1-butyne, 1,3-butadiene, and 2-butyne), and 70 (2-butenal, methyl vinyl ketone, and 3-butenal).	Oxygen	101-107	small nucleolar RNA, C/D box 7	Homo sapiens	293-297
29032642-3	2017	The light-dependent ATPase activity of CMV was lowered in the presence of O2, but the activity increased to the level observed under anaerobic condition when the reaction mixture was supplemented with ascorbic acid (&gt;=0.5 mM).	Oxygen	74-76	dynein axonemal heavy chain 8	Homo sapiens	20-26
31215575-3	2019	In this study, we presented the synthesis of a Co-containing metal-organic framework (Co-MOF) and explored its electrocatalytic application towards the oxygen electrocatalysis (i.e. the oxygen reduction reaction and oxygen evolution reaction).	Oxygen	186-192	lysine acetyltransferase 8	Homo sapiens	89-92
30508396-5	2019	Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including beta-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-gammaH2A.X (phosphorylated gamma-histone family member X).	Oxygen	25-27	galactosidase beta 1	Homo sapiens	117-135
29024190-1	2017	Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for beta-1,4-galactosyltransferase 7 (beta4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains.	Oxygen	55-61	beta-1,4-galactosyltransferase 7	Homo sapiens	123-155
29024190-1	2017	Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for beta-1,4-galactosyltransferase 7 (beta4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains.	Oxygen	55-61	beta-1,4-galactosyltransferase 7	Homo sapiens	157-167
29160314-0	2017	A bimetallic carbide derived from a MOF precursor for increasing electrocatalytic oxygen evolution activity.	Oxygen	82-88	lysine acetyltransferase 8	Homo sapiens	36-39
29206217-3	2017	The simultaneous thermogravimetric and mass spectrometry analyses of the EtOSZ under helium revealed cleavage of oxygen-carbon bond of the EtO group to evolve ethylene as a main gaseous species formed in-situ, which lead to the formation at 800  C of quaternary amorphous Si-C-N with an extremely low carbon content (1.1 wt %) when compared to the theoretical EtOSZ (25.1 wt %).	Oxygen	113-119	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	73-76
28885597-8	2017	Our study demonstrates that oxygen tension is a key factor for chondrogenesis and suggests that UBC-MSCs 3D-culture should begin in normoxia to obtain a more efficient chondrocyte differentiation before placing them in hypoxia for chondrocyte phenotype stabilization.	Oxygen	28-34	ubiquitin C	Homo sapiens	96-99
28544901-5	2017	Large amount of reactive oxygen species (HO2- and  OH) were in-situ electro-generated from the two-electron oxygen reduction and chromium-induced alkaline electro-Fenton-like reaction.	Oxygen	25-31	heme oxygenase 2	Homo sapiens	41-44
28687315-3	2017	However, little is known about the involvement of NADPH oxidase 2 (Nox2), a multisubunit enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the pathogenesis of AD.	Oxygen	128-134	cytochrome b-245, beta polypeptide	Mus musculus	50-65
31063765-2	2019	CACT transport activity, which was strongly impaired after oxidation by atmospheric O2 or H2O2, due to the formation of a disulfide bridge between cysteines 136 and 155, was restored by externally added polyphenols.	Oxygen	84-86	solute carrier family 25 member 20	Homo sapiens	0-4
28687315-3	2017	However, little is known about the involvement of NADPH oxidase 2 (Nox2), a multisubunit enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the pathogenesis of AD.	Oxygen	128-134	cytochrome b-245, beta polypeptide	Mus musculus	67-71
28687315-3	2017	However, little is known about the involvement of NADPH oxidase 2 (Nox2), a multisubunit enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the pathogenesis of AD.	Oxygen	155-161	cytochrome b-245, beta polypeptide	Mus musculus	50-65
28687315-3	2017	However, little is known about the involvement of NADPH oxidase 2 (Nox2), a multisubunit enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the pathogenesis of AD.	Oxygen	155-161	cytochrome b-245, beta polypeptide	Mus musculus	67-71
28852144-6	2017	ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha in mice exposed to chronic mild stress.	Oxygen	50-56	pro-opiomelanocortin-alpha	Mus musculus	135-162
29037892-6	2017	LOX-1 staining revealed that the hybrid-spheroids improved the cell viability, which was potentially due to enhanced transport of oxygen through void space generated by engineered ECM.	Oxygen	130-136	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
29064874-11	2017	Overall, comparing the CPOX group versus the standard monitoring group, there was 34% risk reduction in ICU transfer (P = .06) and odds of recognizing desaturation (oxygen saturation [SpO2] &lt;90% &gt;1 hour) was 15 times higher (P &lt; .00001).	Oxygen	165-171	coproporphyrinogen oxidase	Homo sapiens	23-27
29064874-15	2017	CONCLUSIONS: The use of CPOX on the surgical ward is associated with significant improvement in the detection of oxygen desaturation versus intermittent nursing spot-checks.	Oxygen	113-119	coproporphyrinogen oxidase	Homo sapiens	24-28
31388285-0	2019	Hemoglobin Titusville [alpha2 Codon 94 G&gt;A]: A Rare Alpha Globin Chain Variant Causing Low Oxygen Saturation.	Oxygen	94-100	hemoglobin subunit alpha 2	Homo sapiens	55-67
28842182-11	2017	CXCR4b and CCR9a were both up-regulated not only after bacterial infection, but also after hypoxia stress, providing the linkage between bacterial infection and low oxygen stresses.	Oxygen	165-171	C-X-C chemokine receptor type 4a	Ictalurus punctatus	0-6
28819234-5	2017	Second, Dbx1 preBotC neurons express the hypoxia-inducible transcription factor Hif1a at levels three-times higher than non-Dbx1 neurons, which links core rhythmogenic microcircuits to O2-related chemosensation for the first time.	Oxygen	185-187	developing brain homeobox 1	Mus musculus	8-12
29048538-5	2017	We also discovered that TET expression was enhanced under low oxygen (5%) culture conditions, which facilitated CNS2 DNA demethylation and stabilization of Foxp3 expression in a TET2- and TET3-dependent manner.	Oxygen	62-68	forkhead box P3	Homo sapiens	156-161
31079918-0	2019	GSK621 attenuates oxygen glucose deprivation/re-oxygenation-induced myocardial cell injury via AMPK-dependent signaling.	Oxygen	18-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	95-99
29048538-5	2017	We also discovered that TET expression was enhanced under low oxygen (5%) culture conditions, which facilitated CNS2 DNA demethylation and stabilization of Foxp3 expression in a TET2- and TET3-dependent manner.	Oxygen	62-68	tet methylcytosine dioxygenase 2	Homo sapiens	178-182
29048538-6	2017	In combination with vitamin C treatment, which has been reported to enhance TET catalytic activity, iTregs generated under low oxygen conditions retained more stable Foxp3 expression in vitro and in vivo and exhibited stronger suppression activity in a colitis model compared with untreated iTregs.	Oxygen	127-133	forkhead box P3	Homo sapiens	166-171
28058534-0	2017	Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.	Oxygen	11-17	FERM domain containing kindlin 1	Rattus norvegicus	97-106
27914008-5	2017	In addition, treatment with IGF1R+ hDSCs significantly modulated neurite regeneration and anti-inflammation in vivo in NHI rats and in vitro in primary cortical cultures under oxygen/glucose deprivation.	Oxygen	176-182	insulin-like growth factor 1 receptor	Rattus norvegicus	28-33
31234590-8	2019	In aox1a/pgr5, photosystem II parameters decreased under HL, whereas respiratory O2 uptake rates increased.	Oxygen	81-83	alternative oxidase 1A	Arabidopsis thaliana	3-8
29106766-5	2017	Our data indicated that bovine blastocysts produced in vitro under high oxygen partial pressure possessed elevated ROS abundance and exhibited increased expression of CAT, GLRX2, KEAP1, NFR2, PRDX1, PRDX3, SOD1, TXN, and TXNRD1, versus reduced levels of the oxidative stress-related bta-miR-210.	Oxygen	72-78	catalase	Bos taurus	167-170
28470180-8	2017	Furthermore, our neuroimaging analyses indicated that MYT1L expression associated with hippocampal volume and activation during episodic memory recall, as measured by blood-oxygen-level-dependent (BOLD) signals.	Oxygen	173-179	myelin transcription factor 1 like	Homo sapiens	54-59
29168506-3	2017	Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1.	Oxygen	15-21	NFS1 cysteine desulfurase	Homo sapiens	156-160
29230103-8	2017	Altogether, these findings demonstrated that the up-regulation of VEGFA and its receptors are accompanied by proangiogeneic factor (HIF-1alpha) expression, which were required for angiogenesis to meliorate tibia development of TBCs in hypoxia-induced bone suppression that occurred during O2 supplementation.	Oxygen	289-291	vascular endothelial growth factor A	Gallus gallus	66-71
29124272-3	2017	The experimental results reveal that lithium from the insertion agent combine with the oxygen-containing groups on graphene oxide; this can help in the reduction of hexagonal SnS2 to orthorhombic SnS during calcination and simultaneous pre-occupancy of the edge and defect sites of graphene; thus, additional lithium ion consumption during the initial several lithiation processes is diminished.	Oxygen	87-93	sodium voltage-gated channel alpha subunit 11	Homo sapiens	175-179
29180880-8	2017	Furthermore, we found that cytochrome c oxidase subunit Vb (COX5B), the terminal enzyme of the electron transport chain, was the central gene in a coexpression network that transfers electrons from reduced cytochrome c to oxygen and, in the process, generates an electrochemical gradient across the mitochondrial inner membrane.	Oxygen	222-228	cytochrome c oxidase subunit 5B	Homo sapiens	27-58
29180880-8	2017	Furthermore, we found that cytochrome c oxidase subunit Vb (COX5B), the terminal enzyme of the electron transport chain, was the central gene in a coexpression network that transfers electrons from reduced cytochrome c to oxygen and, in the process, generates an electrochemical gradient across the mitochondrial inner membrane.	Oxygen	222-228	cytochrome c oxidase subunit 5B	Homo sapiens	60-65
29138395-7	2017	Irisin depletion from serum blunts the induction of oxygen consumption rate observed in tubule cells treated with mPGC-1alpha serum.	Oxygen	52-58	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	114-125
29138470-4	2017	During HFD treatment, Lcn2 KO mice exhibited larger brown adipose tissues (BAT), consumed more oxygen, ate more food and gained less body weights as compared to WT mice.	Oxygen	95-101	lipocalin 2	Mus musculus	22-26
29067121-6	2017	The effects of oxygen concentration and testosterone on the expression of hematopoietic-related genes, including homeobox (HOX)A9, HOXB2, HOXB4, HOXC4 and BMI-1, were measured using reverse transcription-quantitative polymerase chain reaction.	Oxygen	15-21	homeobox A9	Homo sapiens	74-129
28863942-3	2017	Mitochondrial isolates from SVCT2+/- mice were observed to consume less oxygen using high-resolution respirometry, and also exhibited decreased mitochondrial membrane potential compared to wild type isolates.	Oxygen	72-78	solute carrier family 23 (nucleobase transporters), member 2	Mus musculus	28-33
28877030-10	2017	The results of this study showed that intranasal delivery of KL4 surfactant was able to preserve lung function as evidenced by adequate arterial oxygen saturation and reduced lung inflammation and oxidative stress; total white count and absolute neutrophil count was decreased in BALF, as were plasma pro-inflammatory cytokine levels and biomarker of oxidative stress.	Oxygen	145-151	immunoglobulin kappa variable 4-60	Mus musculus	61-64
29229088-3	2017	MATERIALS AND METHODS: We measured serum VAP-1 level in 43 patients with stable COPD and 30 control subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral O2 saturation (SpO2), and CAT score.	Oxygen	274-276	amine oxidase copper containing 3	Homo sapiens	41-46
29089753-7	2017	In capillary blood gas analysis, COPD patients had lower partial pressure of oxygen (70.9+-11.5 vs 75.2+-11.0 mmHg, p&lt;0.05) and higher partial pressure of carbon dioxide (36.8+-7.5 vs 34.4+-4.4 mmHg, p&lt;0.05) compared with non-COPD individuals.	Oxygen	77-83	COPD	Homo sapiens	33-37
28952645-4	2017	The significant structural differences between the two isomers, as revealed by the solid-state structures, derives from the regiospecific cleavage of one of the three Os-Os bonds in the intermediate alkenyl cluster Os3(CO)9(mu-C7H4NS)(eta1-EtO2CCCHCO2Et), which follows hydride transfer to the coordinated alkyne ligand in the pi compound HOs3(CO)9(mu-C7H4NS)(eta2-DEAD).	Oxygen	167-172	DNA polymerase iota	Homo sapiens	360-364
28902515-7	2017	Molecular dynamics studies have demonstrated that DNQXA1" binds more effectively to the pocket of the GluA2 than neutral DNQX, and this fact is coherent to the interactions between amidic oxygens and Arg845 being the main interactions of this host-guest system.	Oxygen	188-195	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	102-107
28895781-0	2017	Selective nitration of PsbO1, PsbO2, and PsbP1 decreases PSII oxygen evolution and photochemical efficiency in intact leaves of Arabidopsis.	Oxygen	62-68	PS II oxygen-evolving complex 1	Arabidopsis thaliana	23-28
28895781-0	2017	Selective nitration of PsbO1, PsbO2, and PsbP1 decreases PSII oxygen evolution and photochemical efficiency in intact leaves of Arabidopsis.	Oxygen	62-68	photosystem II subunit P-1	Arabidopsis thaliana	41-46
28895781-2	2017	Our previous findings that light-triggered selective nitration of PsbO1 decreased oxygen evolution and that inhibition of photoelectric electron transport inhibited nitration of PsbO1 implied that the nitratable tyrosine residue of PsbO1 is redox-active.	Oxygen	82-88	PS II oxygen-evolving complex 1	Arabidopsis thaliana	66-71
28895781-5	2017	Because PsbO1, PsbO2, and PsbP1 accounted for &gt; 80% of anti-3-nitrotyrosine antibody signal intensities, observed decreases in the oxygen evolution and maximal photochemical efficiency of PSII were mainly attributable to nitration of the tyrosine residues of these PSII proteins.	Oxygen	134-140	photosystem II subunit P-1	Arabidopsis thaliana	26-31
28731464-2	2017	A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human first trimester HTR-8/SVneo trophoblast cells and placental villous explants exposed to 2% O2.	Oxygen	225-227	matrix metallopeptidase 2	Homo sapiens	97-101
28860005-4	2017	The expression of COMP decreased in a chronic hypoxia rat pH model (P&lt;0.05) and in PASMCs under hypoxia (3%O2) (P&lt;0.05).	Oxygen	110-112	cartilage oligomeric matrix protein	Mus musculus	18-22
28925951-0	2017	Transparent Pullulan/Mica Nanocomposite Coatings with Outstanding Oxygen Barrier Properties.	Oxygen	66-72	MHC class I polypeptide-related sequence A	Homo sapiens	21-25
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Oxygen	220-226	nicotinamide phosphoribosyltransferase	Homo sapiens	155-160
28006954-0	2017	The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson"s Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-kappaB/Nuclear Transcription Factor Related to NF-E2.	Oxygen	119-125	nuclear factor, erythroid derived 2	Mus musculus	196-201
28886081-8	2017	Orexin A oxygen-independently promoted the mRNA and protein expression of HIF-1alpha as well as its nuclear accumulation in HepG2 cells and the elevated HIF-1alpha protein was associated, at least partly, with the activation of the PI3K/Akt/mTOR pathway.	Oxygen	9-15	hypocretin neuropeptide precursor	Homo sapiens	0-6
28715154-4	2017	We found that 2-h hypoxia (8% O2 ) and the intraperitoneal injection of 4 mg kg-1 lipopolysaccharide (LPS) causes the appearance of AKI markers, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the rat urine after 24 and 72 h of exposure.	Oxygen	30-32	lipocalin 2	Rattus norvegicus	190-232
28715154-4	2017	We found that 2-h hypoxia (8% O2 ) and the intraperitoneal injection of 4 mg kg-1 lipopolysaccharide (LPS) causes the appearance of AKI markers, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the rat urine after 24 and 72 h of exposure.	Oxygen	30-32	lipocalin 2	Rattus norvegicus	234-238
28294416-7	2017	In addition, p70S6 kinase phosphorylation (a downstream effector of mTORC1) was reduced when engineered muscle was cultured at 1% O2 , with no significant changes seen above this O2 level.	Oxygen	130-132	CREB regulated transcription coactivator 1	Mus musculus	68-74
28294416-7	2017	In addition, p70S6 kinase phosphorylation (a downstream effector of mTORC1) was reduced when engineered muscle was cultured at 1% O2 , with no significant changes seen above this O2 level.	Oxygen	179-181	CREB regulated transcription coactivator 1	Mus musculus	68-74
28711881-7	2017	Serum YKL-40 was correlated with arterial oxygen pressure (r = -0.40, p &lt; 0.001) and percent-predicted DLCO (r = -0.41, p = 0.01) in patients with PM/DM-ILD.	Oxygen	42-48	chitinase 3 like 1	Homo sapiens	6-12
29637121-0	2017	Improved oxygen systems in district hospitals in Lao PDR: a prospective field trial of the impact on outcomes for childhood pneumonia and equipment sustainability.	Oxygen	9-15	interleukin 4 induced 1	Homo sapiens	49-52
29637121-3	2017	This paper describes implementation of oxygen systems in Lao district hospitals, clinical outcomes after 24 months and equipment outcomes after 40 months postimplementation.	Oxygen	39-45	interleukin 4 induced 1	Homo sapiens	57-60
29637121-10	2017	Conclusion: Medium-term sustainability of oxygen concentrators in hospitals accompanied by reduced case fatality for childhood pneumonia has been demonstrated in Lao PDR.	Oxygen	42-48	interleukin 4 induced 1	Homo sapiens	162-165
28410532-4	2017	Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, which was recued by BMI-1 silencing.	Oxygen	36-42	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	137-142
28740073-3	2017	We further show that recombinant AAV serotype 1 (rAAV1) transduces ECs of pathologic vessels, and that editing of genomic VEGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.	Oxygen	214-220	kinase insert domain protein receptor	Mus musculus	122-128
28740073-5	2017	Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.	Oxygen	186-192	kinase insert domain protein receptor	Mus musculus	71-77
28740863-1	2017	Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3).	Oxygen	240-242	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	7-27
28740863-1	2017	Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3).	Oxygen	240-242	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	29-32
28717592-3	2017	Another recent example of the transfer of adaptive variation between the two species has been suggested by the similarity between high altitude Tibetan mastiffs and wolves at the EPAS1 gene, a transcription factor induced in low oxygen environments.	Oxygen	229-235	endothelial PAS domain protein 1	Canis lupus familiaris	179-184
28695851-1	2017	Cytochrome c oxidase (CcO) couples proton pumping to O2 reduction.	Oxygen	53-55	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
28695851-1	2017	Cytochrome c oxidase (CcO) couples proton pumping to O2 reduction.	Oxygen	53-55	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
28667270-5	2017	Oxygen exposure during isolation/culture markedly inhibited cell division and repressed cell cycle-promoting genes, and subsequent genome-wide analysis identified Fam64a as a novel regulatory molecule.	Oxygen	0-6	PICALM interacting mitotic regulator	Mus musculus	163-169
28667270-6	2017	Fam64a was abundantly expressed in hypoxic fetal cardiomyocyte nuclei, but this expression was drastically repressed by oxygen exposure, and in postnatal cardiomyocytes following the onset of breathing and the resulting elevation of oxygen tension.	Oxygen	120-126	PICALM interacting mitotic regulator	Mus musculus	0-6
28667270-6	2017	Fam64a was abundantly expressed in hypoxic fetal cardiomyocyte nuclei, but this expression was drastically repressed by oxygen exposure, and in postnatal cardiomyocytes following the onset of breathing and the resulting elevation of oxygen tension.	Oxygen	233-239	PICALM interacting mitotic regulator	Mus musculus	0-6
29057303-0	2017	RRM2B: An oxygen-requiring protein with a role in hypoxia.	Oxygen	10-16	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	0-5
29057303-2	2017	We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B.	Oxygen	34-40	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	219-224
29057303-2	2017	We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B.	Oxygen	158-164	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	219-224
28591639-6	2017	Fed mice lacking MFN1 in POMC neurons displayed enhanced hypothalamic mitochondrial oxygen flux and reactive oxygen species generation.	Oxygen	84-90	mitofusin 1	Mus musculus	17-21
28591639-6	2017	Fed mice lacking MFN1 in POMC neurons displayed enhanced hypothalamic mitochondrial oxygen flux and reactive oxygen species generation.	Oxygen	84-90	pro-opiomelanocortin-alpha	Mus musculus	25-29
28589680-7	2017	In mouse RPE cells cultured with high oxygen, CNTF expression and secretion were decreased, but could be recovered after treatment with ATRA.	Oxygen	38-44	ciliary neurotrophic factor	Mus musculus	46-50
28485981-6	2017	The Pd nanoparticles supported on the Ce-MOF store oxygen in the form of a thin palladium oxide layer at the particle-support interface, in addition to the oxygen stored on the Ce(III)/Ce(IV) centers.	Oxygen	51-57	lysine acetyltransferase 8	Homo sapiens	41-44
28485981-7	2017	Oxygen from these reservoirs can be released during CO oxidation at 373 K. At lower temperatures (273 K), the Pd/Ce-MOF has a significant CO2 uptake of 3.5 mmol/g.	Oxygen	0-6	lysine acetyltransferase 8	Homo sapiens	116-119
28569147-9	2017	We hypothesized, and then confirmed by synthesis of the compound, that the actual inhibitor of DUSP5 was a dimeric form of the original inhibitor compound, formed upon exposure to light and oxygen.	Oxygen	190-196	dual specificity phosphatase 5	Homo sapiens	95-100
28527438-5	2017	At 0 K, the minimum energy R  + O2 pathway involves direct elimination of HO2  (30.3 kcal mol-1 barrier) from the tert-butyl peroxy radical (ROO ) to give isobutene.	Oxygen	32-34	heme oxygenase 2	Homo sapiens	74-77
28485395-3	2017	The hybrid nanostructures exhibit overpotentials of 70 mV for hydrogen evolution and 235 mV for oxygen evolution at 10 mA cm-2 with long-term stability, which have superior kinetics for hydrogen- and oxygen-evolution with Tafel slope values of 38.1 and 45.7 mV dec-1.	Oxygen	96-102	deleted in esophageal cancer 1	Homo sapiens	261-266
28485395-3	2017	The hybrid nanostructures exhibit overpotentials of 70 mV for hydrogen evolution and 235 mV for oxygen evolution at 10 mA cm-2 with long-term stability, which have superior kinetics for hydrogen- and oxygen-evolution with Tafel slope values of 38.1 and 45.7 mV dec-1.	Oxygen	200-206	deleted in esophageal cancer 1	Homo sapiens	261-266
28223292-5	2017	Interestingly, LCHF diet administration increased oxygen consumption in a muscle PGC-1alpha-dependent manner, concomitant with a blunted transcriptional induction of genes involved in fatty acid oxidation and impairment in exercise performance.	Oxygen	50-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	81-91
28409279-2	2017	The expression of aquaporin 1 (AQP1), an integral membrane water channel protein involved in the control of these processes, is tightly regulated by oxygen levels.	Oxygen	149-155	aquaporin 1	Mus musculus	18-29
28409279-2	2017	The expression of aquaporin 1 (AQP1), an integral membrane water channel protein involved in the control of these processes, is tightly regulated by oxygen levels.	Oxygen	149-155	aquaporin 1	Mus musculus	31-35
28128527-2	2017	The disappearance of a sulphur mass-independent fractionation (S-MIF) signal in rocks &lt;~2.4 Ga has been used to date a dramatic rise in atmospheric oxygen levels.	Oxygen	151-157	macrophage migration inhibitory factor	Homo sapiens	65-68
28406644-6	2017	In H2O, upon visible-light irradiation in the presence of oxygen, no photosubstitution took place, but the amine of complex [1a]PF6 was photooxidized to an imine.	Oxygen	58-64	sperm associated antigen 17	Homo sapiens	128-131
28218825-4	2017	The sulfur modification in the g-CN x structure leads to excellent oxygen evolution reaction activity by lowering the overpotential.	Oxygen	67-73	calnexin	Homo sapiens	33-37
28218825-5	2017	Compared with the previously reported nonmetallic systems and well-established metallic catalysts, the S-modified g-CN x nanostructures show superior performance, requiring a lower overpotential (290 mV) to achieve a current density of 10 mA cm-2 and a Tafel slope of 120 mV dec-1 with long-term durability of 91.2% retention for 18 h. These inexpensive, environmentally friendly, and easy-to-synthesize catalysts with extraordinary performance will have a high impact in the field of oxygen evolution reaction electrocatalysis.	Oxygen	485-491	calnexin	Homo sapiens	116-120
27737615-3	2017	The maximum yield of intracellular esterase and protease was obtained under full oxygen saturation at the beginning of the fermentation.	Oxygen	81-87	HEAT repeat domain-containing protein	Lysinibacillus fusiformis	35-43
28416140-3	2017	However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia.	Oxygen	9-15	ribonucleotide reductase catalytic subunit M1	Homo sapiens	60-64
28416140-3	2017	However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia.	Oxygen	9-15	ribonucleotide reductase catalytic subunit M1	Homo sapiens	74-78
28416140-3	2017	However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia.	Oxygen	9-15	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	79-84
28348240-0	2017	Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A. Endothelial cells (ECs) not only are important for oxygen delivery but also act as a paracrine source for signals that determine the balance between tissue regeneration and fibrosis.	Oxygen	157-163	Kruppel-like factor 2 (lung)	Mus musculus	33-37
28247542-0	2017	Towards an Understanding of Li2 O2 Evolution in Li-O2 Batteries: An In Operando Synchrotron X-ray Diffraction Study.	Oxygen	32-34	ATP binding cassette subfamily A member 12	Homo sapiens	28-31
28247542-4	2017	By quantitatively tracking Li2 O2 during discharge and charge, a two-step process was suggested for both growth and oxidation of Li2 O2 owing to different mechanisms during two stages of both oxygen reduction reaction and oxygen evolution reaction.	Oxygen	192-198	ATP binding cassette subfamily A member 12	Homo sapiens	27-30
28247542-4	2017	By quantitatively tracking Li2 O2 during discharge and charge, a two-step process was suggested for both growth and oxidation of Li2 O2 owing to different mechanisms during two stages of both oxygen reduction reaction and oxygen evolution reaction.	Oxygen	192-198	ATP binding cassette subfamily A member 12	Homo sapiens	129-132
28247542-4	2017	By quantitatively tracking Li2 O2 during discharge and charge, a two-step process was suggested for both growth and oxidation of Li2 O2 owing to different mechanisms during two stages of both oxygen reduction reaction and oxygen evolution reaction.	Oxygen	222-228	ATP binding cassette subfamily A member 12	Homo sapiens	27-30
28247542-4	2017	By quantitatively tracking Li2 O2 during discharge and charge, a two-step process was suggested for both growth and oxidation of Li2 O2 owing to different mechanisms during two stages of both oxygen reduction reaction and oxygen evolution reaction.	Oxygen	222-228	ATP binding cassette subfamily A member 12	Homo sapiens	129-132
28323554-5	2017	If this postulation is correct, the nitration of 9Tyr of PsbO1 should decrease oxygen evolution activity.	Oxygen	79-85	PS II oxygen-evolving complex 1	Arabidopsis thaliana	57-62
28323554-6	2017	We investigated the effects of PsbO1 nitration on oxygen evolution from isolated thylakoid membranes, and found that nitration decreased oxygen evolution to &gt;= 0% of the control.	Oxygen	50-56	PS II oxygen-evolving complex 1	Arabidopsis thaliana	31-36
28323554-6	2017	We investigated the effects of PsbO1 nitration on oxygen evolution from isolated thylakoid membranes, and found that nitration decreased oxygen evolution to &gt;= 0% of the control.	Oxygen	137-143	PS II oxygen-evolving complex 1	Arabidopsis thaliana	31-36
28375145-2	2017	3HAO is a non-heme iron-containing, ring-cleaving extradiol dioxygenase that catalyzes the addition of both atoms of O2 to the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3-HANA) to form quinolinic acid (QUIN).	Oxygen	117-119	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	0-4
28596380-3	2017	However, apo-hemopexin is vulnerable to inactivation by reactive nitrogen (RNS) and oxygen species (ROS) that covalently modify amino acids.	Oxygen	84-90	hemopexin	Homo sapiens	13-22
28527012-5	2017	Oxygen uptake ([Formula: see text]) was lower in the hypocapnia than control trials (822 +- 235 vs. 1645 +- 245 mL min-1; mean +- SD) during Ex1, but not Ex2 or Ex3, without a between-trial difference in the power output during the exercises.	Oxygen	0-6	FERM domain containing 6	Homo sapiens	141-144
28577302-5	2017	Mechanistic-based studies revealed that Ip6k1-/- MSCs express higher MDM2 and lower p53 protein levels resulting in lower intrinsic mitochondrial reactive oxygen species (ROS) levels as compared to Ip6k1+/+ MSCs, but both populations upregulate mitochondrial ROS to similar extents in response to oxygen-induced stress.	Oxygen	155-161	inositol hexaphosphate kinase 1	Mus musculus	40-45
28728562-8	2017	The transcription levels of MnSOD, PRDX5, VEGF and GLUT-3 also significantly increased in 3% O2 compared with 20% O2 (P &lt; 0.05).	Oxygen	93-95	peroxiredoxin 5	Mus musculus	35-40
28724407-6	2017	Structural analyses of the X. dendrorhous P450 proteins showed that all of them have a predicted transmembrane region at their N-terminus and have the conserved domains characteristic of the P450s, including the heme-binding region (FxxGxRxCxG); the PER domain, with the characteristic signature for fungi (PxRW); the ExxR motif in the K-helix region and the oxygen-binding domain (OBD) (AGxDTT); also, the characteristic secondary structure elements of all the P450 proteins were identified.	Oxygen	359-365	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	191-195
31184144-0	2019	Dual-Site Cascade Oxygen Reduction Mechanism on SnO x/Pt-Cu-Ni for Promoting Reaction Kinetics.	Oxygen	18-24	strawberry notch homolog 1	Homo sapiens	48-51
28356444-9	2017	Tspan12/beta-catenin signaling was activated in response to acute and chronic stress in the oxygen-induced retinopathy and very low density lipoprotein receptor mouse model of proliferative retinopathy.	Oxygen	92-98	tetraspanin 12	Mus musculus	0-7
28608694-1	2017	A series of myoglobin active site analogues were synthesized and characterized to investigate the dioxygen binding effects of a flexible distal strap over the coordination site.	Oxygen	98-106	serine/threonine kinase receptor associated protein	Homo sapiens	144-149
28715845-4	2017	OIR was induced in neonatal mice by exposure to 75% oxygen from postnatal day (P) 7 to P12 and to room air from P12 to P17.	Oxygen	52-58	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	87-90
31036561-4	2019	Fyn kinase regulates both of these processes; it mediates PKCdelta-dependent NF-kappaB-p65 nuclear translocation, leading to inflammasome priming, and facilitates alphaSyn import into microglia, contributing to the generation of mitochondrial reactive oxygen species and consequently to inflammasome activation.	Oxygen	252-258	protein kinase C delta	Homo sapiens	58-66
28295806-5	2017	An analysis of transcription elongation complexes, moving for 60 s at an average of 10 nt/s on unlooped DNA templates, revealed that they more often surpassed LacI bound to the lower affinity O2 operator than to the highest affinity Os operator.	Oxygen	192-194	tissue factor pathway inhibitor	Homo sapiens	159-163
30925081-2	2019	TNFalpha activates NADPH oxidase 1 (Nox1) and reactive oxygen species (ROS), including superoxide (O2 -), production extracellularly is required for subsequent signaling in vascular smooth muscle cells (VSMCs).	Oxygen	99-103	NADPH oxidase 1	Homo sapiens	19-34
28662030-8	2017	In ambient oxygen environments, SRB-13 signaling impacts gene expression during spermatogenesis and the sperm"s mitochondria, thereby increasing migration velocity and inhibiting reversals within the hermaphrodite uterus.	Oxygen	11-17	Serpentine receptor class beta-13	Caenorhabditis elegans	32-38
30925081-2	2019	TNFalpha activates NADPH oxidase 1 (Nox1) and reactive oxygen species (ROS), including superoxide (O2 -), production extracellularly is required for subsequent signaling in vascular smooth muscle cells (VSMCs).	Oxygen	99-103	NADPH oxidase 1	Homo sapiens	36-40
28389561-4	2017	NADPH oxidase 4 (NOX4) enzyme, which catalyzes the reduction of O2 to hydrogen peroxide (H2O2), has been implicated in the cardiac and lung myofibroblast phenotype.	Oxygen	64-66	NADPH oxidase 4	Mus musculus	0-15
28389561-4	2017	NADPH oxidase 4 (NOX4) enzyme, which catalyzes the reduction of O2 to hydrogen peroxide (H2O2), has been implicated in the cardiac and lung myofibroblast phenotype.	Oxygen	64-66	NADPH oxidase 4	Mus musculus	17-21
30536763-7	2019	In murine models of proliferative retinal angiogenesis or oxygen-induced retinopathy, administering a monoclonal RhoB antibody (7F7) was sufficient to block neoangiogenesis or avascular pathology, respectively.	Oxygen	58-64	ras homolog family member B	Mus musculus	113-117
28584235-4	2017	Oxygen-induced retinopathy (OIR) of C57BL/6 J mice was induced by exposure of hyperoxia (75% oxygen) from postnatal day 7 (P7) to P12 and then returned to room air.	Oxygen	0-6	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	130-133
30949956-13	2019	These findings suggest that miR-181a protects neurons from apoptosis by inhibiting reelin expression and regulating the Smac/IAP signaling pathway after oxygen-glucose deprivation/reperfusion injury.	Oxygen	153-159	microRNA 181a-2	Mus musculus	28-36
28583723-2	2017	mTOR forms two compositionally and functionally distinct complexes, mTORC1 and mTORC2, which are crucial for coordinating nutrient, energy, oxygen, and growth factor availability with cellular growth, proliferation, and survival.	Oxygen	140-146	CREB regulated transcription coactivator 1	Mus musculus	68-74
28583723-2	2017	mTOR forms two compositionally and functionally distinct complexes, mTORC1 and mTORC2, which are crucial for coordinating nutrient, energy, oxygen, and growth factor availability with cellular growth, proliferation, and survival.	Oxygen	140-146	CREB regulated transcription coactivator 2	Mus musculus	79-85
31026348-0	2019	UBC-Nepal expedition: phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude.	Oxygen	114-120	ubiquitin C	Homo sapiens	0-3
28257831-0	2017	Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.	Oxygen	113-119	lectin, galactose binding, soluble 1	Mus musculus	13-23
28257831-4	2017	Here, we investigated the anti-angiogenic effect of silencing Gal-1 through intravitreal injection in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	119-125	lectin, galactose binding, soluble 1	Mus musculus	62-67
30952085-5	2019	Whereas, APX (ascorbate peroxidase), DHAR (dehydroascorbate reductase) and GR (glutathione reductase) activities were inhibited under elevated temperature regime or waterlogging event, especially in the treatment of EW6 (soil waterlogging for 6 d under elevated temperature for 2-3  C), which resulted in increasing H2O2 concentration and higher O2- generation rate.	Oxygen	318-320	L-ascorbate peroxidase, cytosolic-like	Gossypium hirsutum	9-12
28601310-0	2017	Hemoglobin-based oxygen carriers promote systemic hyperfibrinolysis that is both dependent and independent of plasmin.	Oxygen	17-23	plasminogen	Homo sapiens	110-117
31038957-0	2019	Uncovered Dynamic Coupling Resolves the Ambiguous Mechanism of Phenylalanine Hydroxylase Oxygen Binding.	Oxygen	89-95	phenylalanine hydroxylase	Homo sapiens	63-88
31038957-3	2019	Despite intensive study, there is no consensus on the atomistic details of the mechanism of O2 binding and splitting by wild-type (WT) PAH and how it varies with PKU-inducing mutations, Arg158Gln and Glu280Lys.	Oxygen	92-94	phenylalanine hydroxylase	Homo sapiens	135-138
28214987-4	2017	A normally occurring increase in oxygen consumption by highly elevated K+ concentrations is absent in Jimpy brain slices and cultured astrocytes, reflecting that Plp at early embryonic stages affects common precursors as also shown by the ability of conditioned medium from normal astrocytes to counteract histological abnormalities.	Oxygen	33-39	proteolipid protein (myelin) 1	Mus musculus	162-165
30913361-4	2019	The MOF NSs can be directly used as efficient electrocatalysts for the oxygen evolution reaction, in which the Ni-Fe-MOF NSs deliver a current density of 10 mA cm-2 at a low overpotential of 221 mV with a small Tafel slope of 56.0 mV dec-1 , and exhibit excellent stability for at least 20 h without obvious activity decay.	Oxygen	71-77	deleted in esophageal cancer 1	Homo sapiens	234-239
28337518-5	2017	Under oxygen deficiency, enhancements of the transcripts of alcohol dehydrogenase 1 (ADH1) and pyruvate decarboxylase 1 (PDC1) and the activities of ADH, PDC and lactate dehydrogenase in WT are clearly reduced in the single mutants, and more strongly reduced in the double mutant.	Oxygen	6-12	alcohol dehydrogenase 1	Arabidopsis thaliana	60-83
28337518-5	2017	Under oxygen deficiency, enhancements of the transcripts of alcohol dehydrogenase 1 (ADH1) and pyruvate decarboxylase 1 (PDC1) and the activities of ADH, PDC and lactate dehydrogenase in WT are clearly reduced in the single mutants, and more strongly reduced in the double mutant.	Oxygen	6-12	alcohol dehydrogenase 1	Arabidopsis thaliana	85-89
31052217-7	2019	The products NHC-B(S2C2H4)(C C-R1) are remarkably stable towards water and air, which suggests their use as boron-based building blocks for applications akin to oxygen-based boronate esters.	Oxygen	161-167	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	29-33
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Oxygen	52-58	jagged canonical Notch ligand 2	Homo sapiens	95-99
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Oxygen	52-58	jagged canonical Notch ligand 2	Homo sapiens	121-125
28330872-2	2017	NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates O2, is highly expressed in colon cancer.	Oxygen	77-79	NADPH oxidase 1	Homo sapiens	0-15
28330872-2	2017	NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates O2, is highly expressed in colon cancer.	Oxygen	77-79	NADPH oxidase 1	Homo sapiens	17-21
30924638-4	2019	Owing to the strong oxygen adsorption of SnO2, oxygen-reduction reactions tend to occur on composite cathode surfaces, resulting in the formation of flake-like discharge products of Li2- xO2 less than 10 nm in thickness rather than toroidal particles of several hundred nanometers.	Oxygen	47-53	ATP binding cassette subfamily A member 12	Homo sapiens	182-185
28148493-7	2017	ATP allosterically inhibited both velocity and affinity for oxygen in COX assayed from both muscle (predominantly COX4-2) and gill (predominantly COX4-1).	Oxygen	60-66	cytochrome c oxidase subunit 8A	Homo sapiens	70-73
28148493-7	2017	ATP allosterically inhibited both velocity and affinity for oxygen in COX assayed from both muscle (predominantly COX4-2) and gill (predominantly COX4-1).	Oxygen	60-66	cytochrome c oxidase subunit 4I2	Homo sapiens	114-120
28148493-7	2017	ATP allosterically inhibited both velocity and affinity for oxygen in COX assayed from both muscle (predominantly COX4-2) and gill (predominantly COX4-1).	Oxygen	60-66	cytochrome c oxidase subunit 4I1	Homo sapiens	146-152
28451371-1	2017	CuII2(mu-eta2:eta2-peroxido) and CuIII2(mu-oxido)2 cores represent key intermediates in copper/dioxygen chemistry, and they are mechanistically important for biological hydroxylation and oxidation reactions mediated by dinuclear (type III) copper metalloenzymes.	Oxygen	95-103	DNA polymerase iota	Homo sapiens	9-13
28451371-1	2017	CuII2(mu-eta2:eta2-peroxido) and CuIII2(mu-oxido)2 cores represent key intermediates in copper/dioxygen chemistry, and they are mechanistically important for biological hydroxylation and oxidation reactions mediated by dinuclear (type III) copper metalloenzymes.	Oxygen	95-103	DNA polymerase iota	Homo sapiens	14-18
30975299-10	2019	Expression of the glucose transporter Glut1 and of glycolytic enzymes as well as mitochondrial oxygen consumption were all highly sensitive to CD28 blockade.	Oxygen	95-101	CD28 molecule	Homo sapiens	143-147
28301257-1	2017	Active oxygen derived from gp91phox is critical for gestation.	Oxygen	7-13	cytochrome b-245, beta polypeptide	Mus musculus	27-35
28290657-4	2017	Benefiting from the advantages of a hollow structure, nanosheet units and high Co3+ content, Co9S8 hollow microplates exhibit remarkable catalytic property for oxygen evolution reaction (OER) with low overpotential of 278 mV to reach a current density of 10 mA cm-2, a low Tafel slope of 53 mV dec-1, and satisfied stability.	Oxygen	160-166	deleted in esophageal cancer 1	Homo sapiens	294-299
28323554-0	2017	Selective nitration of PsbO1 inhibits oxygen evolution from isolated Arabidopsis thylakoid membranes.	Oxygen	38-44	PS II oxygen-evolving complex 1	Arabidopsis thaliana	23-28
30992469-4	2019	Uncoupling protein 1 mRNA and protein levels and oxygen consumption increased in the brown adipocytes treated with 100 nM CXCL12 peptide.	Oxygen	49-55	chemokine (C-X-C motif) ligand 12	Mus musculus	122-128
28321449-7	2017	Pt@CeO2-delta-rich core-shell nanostructures can optimize the density of oxygen vacancies (Ov) as active sites located at the interface of Pt-Ce1-xZrxO2.	Oxygen	73-79	carboxylesterase 1	Homo sapiens	142-145
30892359-3	2019	Notaly the reaction uses O2 as the terminal oxidant, instead of metal catalysts or oxidants like TBHP, leading to H2O and N2 as the clean by-products.	Oxygen	25-27	MT-RNR2 like 2 (pseudogene)	Homo sapiens	114-124
28325907-4	2017	Furthermore, a UV-O3 surface treatment induced excess Ti3+ surface states and oxygen vacancies which synergistically enhanced the photodegradation rate constant to 0.030 min-1 for 17 nm Ag2S@TiO2 sample which is ~70% better than the previously reported for Ag2S/TiO2 hierarchical spheres.	Oxygen	78-84	angiotensin II receptor type 1	Homo sapiens	186-190
28325907-4	2017	Furthermore, a UV-O3 surface treatment induced excess Ti3+ surface states and oxygen vacancies which synergistically enhanced the photodegradation rate constant to 0.030 min-1 for 17 nm Ag2S@TiO2 sample which is ~70% better than the previously reported for Ag2S/TiO2 hierarchical spheres.	Oxygen	78-84	angiotensin II receptor type 1	Homo sapiens	257-261
28104917-11	2017	These changes in BMP-3b Tg mice were accompanied by increased energy expenditure, indicated as increased locomotor activity and oxygen consumption.	Oxygen	128-134	growth differentiation factor 10	Mus musculus	17-23
28400504-2	2017	When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen-dependent prolyl hydroxylase domain (PHD) proteins, promoting its association with the von Hippel-Lindau (VHL) ubiquitin E3 ligase and subsequent proteosomal degradation.	Oxygen	5-11	von Hippel-Lindau tumor suppressor	Homo sapiens	163-180
28400504-2	2017	When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen-dependent prolyl hydroxylase domain (PHD) proteins, promoting its association with the von Hippel-Lindau (VHL) ubiquitin E3 ligase and subsequent proteosomal degradation.	Oxygen	69-75	von Hippel-Lindau tumor suppressor	Homo sapiens	163-180
30702344-3	2019	Nox2 generation of O2 -, in addition to signaling, can contribute to oxidative stress and inflammation such as during sepsis-induced acute lung injury (ALI).	Oxygen	19-21	cytochrome b-245, beta polypeptide	Mus musculus	0-4
28202541-1	2017	The Mga2 and Sre1 transcription factors regulate oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 transcription factors.	Oxygen	49-55	Mga2p	Saccharomyces cerevisiae S288C	4-8
30680696-5	2019	Calgranulin B showed several significant correlations with functional parameters (oxygen demand at rest, 6-min walking test (6MWT), and PFTs); KL-6 was correlated with oxygen demand at rest and during 6MWT.	Oxygen	168-174	mucin 1, cell surface associated	Homo sapiens	143-147
27721400-0	2017	Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells.	Oxygen	83-85	superoxide dismutase 2	Homo sapiens	47-52
27721400-2	2017	We previously reported activation of a key oncogenic signaling cascade via mammalian target of rapamycin (mTOR) signaling complex-2 (mTORC2) owing to estrogen receptor (ER-alpha)-dependent augmentation of O2.- within the mitochondria of 17-beta-estradiol (E2)-stimulated breast cancer cells.	Oxygen	205-207	CREB regulated transcription coactivator 2	Mus musculus	133-139
27721400-3	2017	Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells.	Oxygen	104-106	superoxide dismutase 2	Homo sapiens	0-30
27721400-3	2017	Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells.	Oxygen	104-106	superoxide dismutase 2	Homo sapiens	32-37
27721400-3	2017	Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells.	Oxygen	227-229	superoxide dismutase 2	Homo sapiens	0-30
27721400-3	2017	Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells.	Oxygen	227-229	superoxide dismutase 2	Homo sapiens	32-37
27721400-9	2017	In addition, we also observed diminished interaction of MnSOD with sirtuin-3, the key mitochondrial deacetylase that deacetylates MnSOD at critical K68 and thereby activates it for scavenging O2.-.	Oxygen	192-194	superoxide dismutase 2	Homo sapiens	56-61
27721400-10	2017	Consequently, compromised deacetylation of MnSOD at K68 leading to its inhibition and a resultant buildup of O2.- within the mitochondria culminated in the activation of mTORC2.	Oxygen	109-111	superoxide dismutase 2	Homo sapiens	43-48
27721400-10	2017	Consequently, compromised deacetylation of MnSOD at K68 leading to its inhibition and a resultant buildup of O2.- within the mitochondria culminated in the activation of mTORC2.	Oxygen	109-111	CREB regulated transcription coactivator 2	Mus musculus	170-176
28302994-10	2017	Furthermore, hTSCs cultured in 20% O2 exhibited significantly higher expression of the 3 markers (PPAR-gamma, Sox-9, and Runx-2).	Oxygen	35-37	SRY-box transcription factor 9	Homo sapiens	110-115
28117969-2	2017	Herein, we first report an oxygen-evolving cobalt-citrate metal-organic framework (MOF, UTSA-16) for highly efficient electrocatalytic water oxidation.	Oxygen	27-33	lysine acetyltransferase 8	Homo sapiens	58-95
26147945-9	2017	The maximal oxygen consumption (VO2 max) was in a negative relationship with HRR1 and in a positive one with HRR3 (P&lt;0 05) with respect to all athletes.	Oxygen	12-18	nuclear receptor subfamily 1 group H member 4	Homo sapiens	77-81
27344668-1	2017	The relation between cerebral blood flow (CBF) and cerebral oxygen extraction fraction (OEF) can be expressed using the effective diffusivity for oxygen in the capillary bed (D) as OEF = 1 - exp(-D/CBF).	Oxygen	60-66	sterile alpha motif domain containing 9	Homo sapiens	181-188
27344668-1	2017	The relation between cerebral blood flow (CBF) and cerebral oxygen extraction fraction (OEF) can be expressed using the effective diffusivity for oxygen in the capillary bed (D) as OEF = 1 - exp(-D/CBF).	Oxygen	146-152	sterile alpha motif domain containing 9	Homo sapiens	181-188
28292469-7	2017	A number of transcription factors known to regulate BCRP, including AHR, NRF2 and PPARgamma, were also coordinately down-regulated by 3% oxygen in BeWo cells.	Oxygen	137-143	aryl hydrocarbon receptor	Homo sapiens	68-71
27648691-13	2017	Plasma galectin-3 levels were significantly correlated with acute physiology and chronic health evaluation II scores and arterial oxygen tension/inspiratory oxygen fraction ratios (Spearman rho = 0.44, P &lt;0.0001 and -0.616, P &lt;0.0001, respectively).	Oxygen	130-136	galectin 3	Homo sapiens	7-17
27648691-13	2017	Plasma galectin-3 levels were significantly correlated with acute physiology and chronic health evaluation II scores and arterial oxygen tension/inspiratory oxygen fraction ratios (Spearman rho = 0.44, P &lt;0.0001 and -0.616, P &lt;0.0001, respectively).	Oxygen	157-163	galectin 3	Homo sapiens	7-17
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	TNF alpha induced protein 3	Homo sapiens	93-100
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	inhibitor of DNA binding 1, HLH protein	Homo sapiens	152-155
28207746-5	2017	We studied the effect on proteinase K (PK) resistance of the amino acid substitution Y169F, which removes a single oxygen atom from the beta2-alpha2 loop of the cellular prion protein (PrPC).	Oxygen	115-121	prion protein	Mus musculus	185-189
28102675-8	2017	The amine is proposed to perform a nucleophilic attack at a terminal eta2-carboxylate ligand of the zirconium catalyst, followed by a C-O bond cleavage step, with an intermediate proton transfer from nitrogen to oxygen facilitated by an additional equivalent of amine.	Oxygen	212-218	DNA polymerase iota	Homo sapiens	69-73
28507790-3	2017	In line with this, human and mouse CD3-stimulated lymphocytes cultured under hypoxia (1% O2) showed increased expression of CD69 at the protein and mRNA level.	Oxygen	89-91	CD3 antigen, epsilon polypeptide	Mus musculus	35-38
28507790-3	2017	In line with this, human and mouse CD3-stimulated lymphocytes cultured under hypoxia (1% O2) showed increased expression of CD69 at the protein and mRNA level.	Oxygen	89-91	CD69 antigen	Mus musculus	124-128
28507790-7	2017	These results uncover a connection between the HIF-1alpha oxygen-sensing pathway and CD69 immunobiology.	Oxygen	58-64	CD69 antigen	Mus musculus	85-89
28067317-2	2017	Herein we found the enrichment of G6PI in microvascular endothelial cells of synovial tissue in RA patients, where a 3% O2 hypoxia environment has been identified.	Oxygen	120-122	glucose-6-phosphate isomerase	Homo sapiens	34-38
28067317-3	2017	In order to determine the correlation between the high G6PI level and the low oxygen concentration in RA, a hypoxia condition (~3% O2) in vitro was applied to mimic the RA environment in vivo.	Oxygen	78-84	glucose-6-phosphate isomerase	Homo sapiens	55-59
28060894-0	2017	The Effect of Cadence on Shank Muscle Oxygen Consumption and Deoxygenation in Relation to Joint Specific Power and Cycling Kinematics.	Oxygen	38-44	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	25-30
29047102-8	2017	Interventions such as long-term oxygen therapy, endothelium-targeted treatment, and pharmacological therapies show promising results in improving the life span of COPD patients and attenuating the progression of pulmonary hypertension.	Oxygen	32-38	COPD	Homo sapiens	163-167
28532286-0	2017	Hb Bakersfield (HBA1: c.151_152insGGAGCC): The Insertion of Arg-His Between Codons 49 and 50 of the alpha1-Globin Chain Leads to Increased Oxygen Affinity.	Oxygen	139-145	hemoglobin subunit alpha 1	Homo sapiens	16-20
27986613-0	2017	Oxygen flux reduces Cux1 positive neurons and cortical growth in a gestational rodent model of growth restriction.	Oxygen	0-6	cut like homeobox 1	Homo sapiens	20-24
28017862-7	2017	Further, Pex16-silencing decreased cellular oxygen consumption and increased FA release.	Oxygen	44-50	peroxisomal biogenesis factor 16	Mus musculus	9-14
27930438-8	2017	Furthermore, CRF assessed by volume oxygen peak was associated with insulin levels (r = -0.273; P &lt; 0.05), the SD of the NN interval series (r = 0.268, P &lt; 0.05) and the long-term variation using the Poincare plot (PS1: r = 0.275, P &lt; 0.05; PS2: r = 0.273, P &lt; 0.05).	Oxygen	36-42	taste 2 receptor member 62 pseudogene	Homo sapiens	221-224
28193888-7	2017	Mechanistically, treatment with IL-37 induced marked metabolic changes with higher levels of muscle AMPK, greater rates of oxygen consumption, and increased oxidative phosphorylation.	Oxygen	123-129	interleukin 37	Homo sapiens	32-37
28242826-8	2017	The COX-2 signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2-deficient mice may be able to access COX-2-independent mechanisms to achieve hypoxic acclimatization.	Oxygen	74-80	prostaglandin-endoperoxide synthase 2	Mus musculus	4-9
28099844-0	2017	Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.	Oxygen	99-105	acyl-CoA synthetase short chain family member 2	Homo sapiens	31-54
28099844-7	2017	Surprisingly, oxygen and serum limitation increase nuclear localization of ACSS2.	Oxygen	14-20	acyl-CoA synthetase short chain family member 2	Homo sapiens	75-80
30726964-10	2019	Expression of a number of RAS mRNAs (ATP6AP2, AGT, ACE and AGTR1) were increased in either, or both, 1 and 5% oxygen compared with 20% oxygen.	Oxygen	110-116	angiotensin II receptor type 1	Homo sapiens	59-64
30772257-4	2019	METHODS: We studied the mechanisms linking GCG action to acute increases in oxygen consumption using wildtype (WT), Ucp1-/- and Fgf21-/- mice.	Oxygen	76-82	glucagon	Mus musculus	43-46
30772257-7	2019	GCG increased energy expenditure (measured by oxygen consumption) both in vivo in WT mice and ex vivo in BAT and liver explants.	Oxygen	46-52	glucagon	Mus musculus	0-3
30772257-9	2019	However, acute GCG administration also robustly increased oxygen consumption in GcgrBAT-/- mice.	Oxygen	58-64	glucagon	Mus musculus	15-18
30772257-9	2019	However, acute GCG administration also robustly increased oxygen consumption in GcgrBAT-/- mice.	Oxygen	58-64	glucagon receptor	Mus musculus	80-87
27966451-3	2017	Consistent with their enhanced growth properties, FGFR4-R388-expressing cells show higher mitochondrial STAT3 serine phosphorylation driving basal and maximal oxygen consumption rate (OCR) than pituitary cells expressing the more common FGFR4-G388 isoform.	Oxygen	159-165	fibroblast growth factor receptor 4	Homo sapiens	50-55
30482269-4	2019	We hypothesised that the presence of haemoglobin invivo creates a low oxygen environment to induce oxygen-regulated gene expression, supported by high expression of Slc2a1 and Ndrg1 in invivo relative to invitro embryos.	Oxygen	99-105	N-myc downstream regulated gene 1	Mus musculus	176-181
29047077-2	2017	Elevated production of reactive oxygen species (ROS) by NADPH oxidase 4 (Nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis.	Oxygen	32-38	NADPH oxidase 4	Homo sapiens	56-71
29047077-2	2017	Elevated production of reactive oxygen species (ROS) by NADPH oxidase 4 (Nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis.	Oxygen	32-38	NADPH oxidase 4	Homo sapiens	73-77
30817128-0	2019	Formation and Effect of Residual Lithium Compounds on Li-Rich Cathode Material Li1.35[Ni0.35Mn0.65]O2.	Oxygen	99-101	transglutaminase 1	Homo sapiens	79-82
28429326-8	2017	In addition, acetyl-CoA is provided in the anaerobic cells from pyruvate by the action of a unique enzyme, oxygen sensitive pyruvate:NADP+ oxidoreductase, instead of the common pyruvate dehydrogenase multienzyme complex.Wax esters produced by anaerobic Euglena are promising biofuels because myristic acid (C14:0) in contrast to other algal produced fatty acids, such as palmitic acid (C16:0) and stearic acid (C18:0), has a low freezing point making it suitable as a drop-in jet fuel.	Oxygen	107-113	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	139-153
28551790-3	2017	Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is important for mitochondrial function in terms of oxygen consumption and potassium fluxes.	Oxygen	165-171	gap junction protein alpha 1	Homo sapiens	52-56
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Oxygen	30-32	ataxia telangiectasia mutated	Mus musculus	65-68
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Oxygen	30-32	ataxia telangiectasia mutated	Mus musculus	90-93
27758776-6	2017	RESULTS: Visually, temporal-shift analysis of blood oxygen level-dependent MR imaging data identified regions with compromised hemodynamics as defined by DSC, though performance deteriorated in patients with bilateral disease.	Oxygen	52-58	desmocollin 3	Homo sapiens	154-157
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Oxygen	30-32	ataxia telangiectasia mutated	Mus musculus	90-93
30395686-10	2019	In addition, plasma of Polg2+ / Y265X mice, compared to Polg2+ / + littermates had higher levels of reactive oxygen species.	Oxygen	109-115	polymerase (DNA directed), gamma 2, accessory subunit	Mus musculus	23-28
27758776-10	2017	CONCLUSIONS: Temporal-shift analysis of blood oxygen level-dependent MR imaging can identify brain regions with hemodynamic compromise in relation to DSC among patients with chronic cerebrovascular disease.	Oxygen	46-52	desmocollin 3	Homo sapiens	150-153
28068148-6	2017	A total of 1.8 g d-1 "unknown oxygen" emerged between the input and output of the plant growth module.	Oxygen	30-36	leiomodin 1	Homo sapiens	17-20
30635773-9	2019	However, under stress conditions, such as high pH or oxygen limitation, MIC13-disrupted parasites showed significantly slower growth rates compared to the parental strains, suggesting that it is required for optimal parasite growth under bradyzoite-inducing or stress conditions.	Oxygen	53-59	MIC13	Toxoplasma gondii ME49	72-77
28007055-4	2017	Both the GLP-1, oxyntomodulin and GLP-1 + glucagon infusions appeared to increase O2 compared to saline but this observation is most likely confounded by a residual meal-induced thermogenesis because the calorimetry was performed relatively soon after the paracetamol peak indicating that a considerable volume still resided in the stomach and a high rate of nutrient absorption probably was still going on compared to the saline infusion.	Oxygen	82-84	glucagon like peptide 1 receptor	Homo sapiens	9-14
28007055-4	2017	Both the GLP-1, oxyntomodulin and GLP-1 + glucagon infusions appeared to increase O2 compared to saline but this observation is most likely confounded by a residual meal-induced thermogenesis because the calorimetry was performed relatively soon after the paracetamol peak indicating that a considerable volume still resided in the stomach and a high rate of nutrient absorption probably was still going on compared to the saline infusion.	Oxygen	82-84	glucagon like peptide 1 receptor	Homo sapiens	34-39
30459266-5	2019	Transient assays in Arabidopsis (Arabidopsis thaliana) mesophyll protoplasts indicated that a combination of the yeast Gal4/upstream activating sequence system and the mammalian oxygen sensor machinery can be used effectively to engineer a modular, oxygen-inducible transcriptional regulator.	Oxygen	178-184	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	119-123
27890795-3	2017	This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2.	Oxygen	282-284	E1A binding protein p300	Homo sapiens	101-105
27787886-5	2017	Furthermore, Ngb treatment abolishes H2 O2 -induced increase in mitochondrial oxygen consumption rates.	Oxygen	78-84	neuroglobin	Mus musculus	13-16
28168008-2	2017	The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD.	Oxygen	36-42	huntingtin	Homo sapiens	152-155
28593021-1	2017	Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen.	Oxygen	143-149	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
28108649-3	2017	Therefore, this study set out to test the hypothesis that the restriction in mV O2 is regulated by the net decrease in intracellular oxygen tension equilibrated with myoglobin oxygen saturation ( PmbO2) during muscle contraction under hypoxic conditions.	Oxygen	80-82	myoglobin	Rattus norvegicus	166-175
27803158-6	2016	Carcinoma cells overexpressing TIGAR have higher oxygen consumption rates and ATP levels when exposed to glutamine, lactate, or the combination of glutamine and lactate.	Oxygen	49-55	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	31-36
27935942-10	2016	Down-regulation of BDNF-AS increased cell viability and decreased the number of TUNEL-positive retinal ganglion cells under oxygen and glucose deprivation conditions.	Oxygen	124-130	BDNF antisense RNA	Homo sapiens	19-26
27824191-2	2016	The synthesized N,S-hcs nanomaterials exhibited favourable catalytic activity for the oxygen reduction reaction (ORR) compared to carbon spheres doped solely with nitrogen (N-hcs), polypyrrole (PPY) solid nanoparticles and irregular fragments of polyaniline (PAN).	Oxygen	86-92	holocarboxylase synthetase	Homo sapiens	20-23
27844077-2	2016	Heme binds both amyloid beta (Abeta) and human islet amyloid polypeptide (hIAPP) to form heme-Abeta and heme-hIAPP complexes, respectively, and form reactive oxygen species (ROS) like H2O2, O2 -etc., which are known to cause oxidative damage.	Oxygen	190-194	islet amyloid polypeptide	Homo sapiens	74-79
27901130-4	2016	Hypoxia (5% O2) treatment could significantly increase Huwe1 expression during mouse embryo development process.	Oxygen	12-14	HECT, UBA and WWE domain containing 1	Mus musculus	55-60
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	matrix metallopeptidase 9	Mus musculus	294-298
27709901-6	2016	The photochemical formation of H2O2 followed the conservative mixing model due to the reaction of C60 - with HO2 /O2 -, and the biomolecular reaction rate constant has been measured as (7.4 +- 0.6) x 106 M-1 s-1.	Oxygen	33-35	heme oxygenase 2	Homo sapiens	109-112
27656112-4	2016	The toxic effect of Sod1 instability does not correlate with a loss of mitochondrial function or increased production of reactive oxygen species, but instead prevents acidification of the vacuole, perturbs metabolic regulation and promotes senescence.	Oxygen	130-136	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	20-24
27649550-3	2016	Crystal structure analysis, high-level quantum chemistry (QC) calculations and combined quantum mechanics/molecular mechanics (QM/MM) modeling revealed that halogen substitution at position 3 of the benzene moiety of peptide Phe3 residue can constitute a putative halogen bonding, which is shown to be geometrically perpendicular to and energetically independent of a native hydrogen bonding that share a common carbonyl oxygen acceptor.	Oxygen	421-427	dihydrolipoamide dehydrogenase	Homo sapiens	225-229
27748851-5	2016	The current study hypotheses that expression of ORP150 would be increased in osteocytes under hypoxic conditions (1% O2).	Oxygen	117-119	hypoxia up-regulated 1	Mus musculus	48-54
27748851-6	2016	The MLO-Y4 osteocyte cell line was cultured under normoxic or hypoxic conditions for up to 72 h. It was demonstrated that 1% O2 significantly induced hypoxia after 16 h and up to 72 h, significantly reduced cell number at 8 and 48 h, induced cell death at 8, 24 and 48 h and induced apoptosis at 16, 24 and 48 h. Significant differences in ORP150 mRNA were observed at 72 h, however no differences were observed in the protein expression levels.	Oxygen	125-127	hypoxia up-regulated 1	Mus musculus	340-346
27748851-7	2016	The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygen-deprived conditions.	Oxygen	121-127	hypoxia up-regulated 1	Mus musculus	25-31
27841740-10	2016	Twenty weeks of IPW-5371 treatment at 30 mg/kg preserved arterial O2 saturation and cardiac contractile reserve and resulted in significant decreases in breathing frequency and cardiac and pulmonary fibrosis.	Oxygen	66-68	imprinted gene in the Prader-Willi syndrome region	Mus musculus	16-19
27668828-3	2016	However, rapid O2 activation occurs only when WTR is bound to CmlP, the NRPS to which l-PAPA is covalently attached.	Oxygen	15-17	pappalysin 1	Homo sapiens	88-92
27519418-3	2016	In a mouse glioma model, mTORC1 hyperactivation induced by conditional Tsc1 deletion increased numbers of glioma-initiating cells (GICs) in vitro and in vivo Metabolic analysis revealed that mTORC1 hyperactivation enhanced mitochondrial biogenesis, as evidenced by elevations in oxygen consumption rate and ATP production.	Oxygen	279-285	CREB regulated transcription coactivator 1	Mus musculus	25-31
27519418-3	2016	In a mouse glioma model, mTORC1 hyperactivation induced by conditional Tsc1 deletion increased numbers of glioma-initiating cells (GICs) in vitro and in vivo Metabolic analysis revealed that mTORC1 hyperactivation enhanced mitochondrial biogenesis, as evidenced by elevations in oxygen consumption rate and ATP production.	Oxygen	279-285	TSC complex subunit 1	Mus musculus	71-75
27519418-3	2016	In a mouse glioma model, mTORC1 hyperactivation induced by conditional Tsc1 deletion increased numbers of glioma-initiating cells (GICs) in vitro and in vivo Metabolic analysis revealed that mTORC1 hyperactivation enhanced mitochondrial biogenesis, as evidenced by elevations in oxygen consumption rate and ATP production.	Oxygen	279-285	CREB regulated transcription coactivator 1	Mus musculus	191-197
27573911-0	2016	Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes.	Oxygen	31-37	cathepsin D	Homo sapiens	0-11
27572699-2	2016	A Hill-type oxygen diffusion model predicts that oxygen supply is limiting in hypertrophied cardiomyocytes at maximal rates of oxygen consumption and that this limitation can be reduced by increasing the myoglobin (Mb) concentration.	Oxygen	12-18	myoglobin	Rattus norvegicus	204-213
27572699-2	2016	A Hill-type oxygen diffusion model predicts that oxygen supply is limiting in hypertrophied cardiomyocytes at maximal rates of oxygen consumption and that this limitation can be reduced by increasing the myoglobin (Mb) concentration.	Oxygen	12-18	myoglobin	Rattus norvegicus	215-217
27572699-9	2016	The increase in oxidative capacity without an increase in oxygen supply via Mb-facilitated diffusion caused a doubling of the critical extracellular oxygen tension required to prevent hypoxia (PO2crit).	Oxygen	58-64	myoglobin	Rattus norvegicus	76-78
27572699-9	2016	The increase in oxidative capacity without an increase in oxygen supply via Mb-facilitated diffusion caused a doubling of the critical extracellular oxygen tension required to prevent hypoxia (PO2crit).	Oxygen	149-155	myoglobin	Rattus norvegicus	76-78
27539189-6	2016	Cells cultured dynamically at 5% oxygen exhibited the best expansion: 30-fold increase by flow cytometry, 120-fold increase by colony assay, and 11% of human CD45 engraftment in the bone marrow of NOD/SCID mice.	Oxygen	33-39	atrophin 1	Homo sapiens	197-200
28428895-0	2017	Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy.	Oxygen	91-97	lectin, galactose binding, soluble 1	Mus musculus	59-69
28845732-3	2017	Recently, we found that hyperbaric oxygen therapy produces an antinociceptive response via the kindlin-1/wnt-10a signaling pathway in a chronic pain injury model in rats.	Oxygen	35-41	FERM domain containing kindlin 1	Rattus norvegicus	95-104
30459266-5	2019	Transient assays in Arabidopsis (Arabidopsis thaliana) mesophyll protoplasts indicated that a combination of the yeast Gal4/upstream activating sequence system and the mammalian oxygen sensor machinery can be used effectively to engineer a modular, oxygen-inducible transcriptional regulator.	Oxygen	249-255	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	119-123
28845732-8	2017	Results: Our findings demonstrated that hyperbaric oxygen therapy inhibited the chronic constriction injury-induced increase in kindlin-1 expression.	Oxygen	51-57	FERM domain containing kindlin 1	Rattus norvegicus	128-137
28845732-9	2017	Furthermore, overexpression of kindlin-1 reversed the antinociceptive effects of hyperbaric oxygen therapy.	Oxygen	92-98	FERM domain containing kindlin 1	Rattus norvegicus	31-40
30694643-2	2019	Herein, we develop the IR780@O2-SFNs/iRGD as an oxygen self-sufficient and tumor-penetrating nanoplatform, which consists of IR780-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs) and iRGD as a tumor targeting peptide that can penetrate deeper within the tumor.	Oxygen	48-54	interferon gamma inducible protein 47	Mus musculus	37-41
28845732-10	2017	The observed hyperbaric oxygen-induced reductions in glial cell activation and neuroinflammation, as indicated by the production of TNF-alpha, IL-1beta, and fractalkine, were also prominently diminished in the group with kindlin-1 overexpression.	Oxygen	24-30	FERM domain containing kindlin 1	Rattus norvegicus	221-230
28845732-11	2017	Conclusions: Our findings demonstrate that kindlin-1 is a key protein in the action of hyperbaric oxygen therapy in the treatment of neuropathic pain.	Oxygen	98-104	FERM domain containing kindlin 1	Rattus norvegicus	43-52
28685009-8	2017	In the nucleus, MNRR1 binds to a novel promoter element in COX4I2 and itself, increasing transcription at 4% oxygen.	Oxygen	109-115	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	16-21
28685009-8	2017	In the nucleus, MNRR1 binds to a novel promoter element in COX4I2 and itself, increasing transcription at 4% oxygen.	Oxygen	109-115	cytochrome c oxidase subunit 4I2	Homo sapiens	59-65
30694643-2	2019	Herein, we develop the IR780@O2-SFNs/iRGD as an oxygen self-sufficient and tumor-penetrating nanoplatform, which consists of IR780-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs) and iRGD as a tumor targeting peptide that can penetrate deeper within the tumor.	Oxygen	48-54	interferon gamma inducible protein 47	Mus musculus	204-208
30808749-0	2019	Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase.	Oxygen	15-21	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	64-84
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	109-115	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	137-142
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	197-203	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	137-142
28819545-8	2017	Circulating miR-663 proved to be a good classifier for vascular responsiveness to acute O2 and iNO challenges.	Oxygen	88-90	microRNA 663a	Homo sapiens	12-19
30808749-1	2019	Cytochrome c oxidase (CcO) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism.	Oxygen	35-43	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
30808749-1	2019	Cytochrome c oxidase (CcO) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism.	Oxygen	35-43	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
30808749-2	2019	By using time-resolved serial femtosecond crystallography, we identified a key oxygen intermediate of bovine CcO.	Oxygen	79-85	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	109-112
27873505-0	2017	Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model.	Oxygen	11-17	mitogen activated protein kinase 14	Rattus norvegicus	85-121
30736871-9	2019	All three serum markers of AKI (cystatin C, NGAL, and IL-18) studied were positively correlated with OSA severity, and two (cystatin C and IL-18) were positively correlated with the frequency of oxygen desaturation during sleep.	Oxygen	195-201	cystatin C	Homo sapiens	124-134
27743994-6	2016	This work utilized the breast cancer cell line BT-474 treated with 1% O2 or a hypoxia chemical mimetic deferoxamine to determine the minimal promoter region of SLC19A3 responsible for hypoxia responsiveness.	Oxygen	70-72	solute carrier family 19 member 3	Homo sapiens	160-167
30800661-10	2019	Some KMO ligands promote the reaction of NADPH with O2 without hydroxylation, resulting in uncoupled formation of H2O2.	Oxygen	52-54	kynurenine 3-monooxygenase	Rattus norvegicus	5-8
28100855-9	2016	Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen.	Oxygen	177-183	superoxide dismutase 2	Homo sapiens	84-89
27519633-4	2016	Low oxygen level enhanced GC proliferation with high expression levels of HIF-1, VEGF, AKT, mTOR, and S6RP, whereas addition of anti-VEGF antibody decreased cellular proliferation with low phosphorylated AKT and mTOR expression levels.	Oxygen	4-10	AKT serine/threonine kinase 1	Bos taurus	87-90
30638380-7	2019	Notably, with the assistance of a two-photon fluorescence imaging probe of the superoxide anion radical (O2 -), in vivo visualization for the first time revealed the positive correlation between AChE and O2 - levels associated with depressive behaviors.	Oxygen	105-109	acetylcholinesterase	Mus musculus	195-199
27519633-4	2016	Low oxygen level enhanced GC proliferation with high expression levels of HIF-1, VEGF, AKT, mTOR, and S6RP, whereas addition of anti-VEGF antibody decreased cellular proliferation with low phosphorylated AKT and mTOR expression levels.	Oxygen	4-10	mechanistic target of rapamycin kinase	Bos taurus	92-96
30638380-7	2019	Notably, with the assistance of a two-photon fluorescence imaging probe of the superoxide anion radical (O2 -), in vivo visualization for the first time revealed the positive correlation between AChE and O2 - levels associated with depressive behaviors.	Oxygen	204-208	acetylcholinesterase	Mus musculus	195-199
27707706-6	2016	Under baseline conditions, NHE3, NKCC2, NCC, and ENaC reabsorb 36, 22, 4, and 7%, respectively, of filtered Na+ The model predicted that inhibition of NHE3 substantially reduced proximal tubule TNa and oxygen consumption (QO2 ).	Oxygen	202-208	solute carrier family 9 member A3	Rattus norvegicus	27-31
27707706-6	2016	Under baseline conditions, NHE3, NKCC2, NCC, and ENaC reabsorb 36, 22, 4, and 7%, respectively, of filtered Na+ The model predicted that inhibition of NHE3 substantially reduced proximal tubule TNa and oxygen consumption (QO2 ).	Oxygen	202-208	solute carrier family 9 member A3	Rattus norvegicus	151-155
27693962-0	2016	Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning.	Oxygen	50-56	mitogen activated protein kinase 3	Rattus norvegicus	40-46
30194449-2	2019	pVHL is a tumor-suppressor protein implicated in a variety of cellular processes, most notably in response to changes in oxygen availability, due to its role as part of an E3-ligase complex which targets the hypoxia-inducible factor (HIF) for degradation.	Oxygen	121-127	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
27854125-5	2016	Besides, the apelin/APJ system prevents mitochondrial oxygen damage and lipid peroxidation through nitric oxide formation.	Oxygen	54-60	apelin receptor	Homo sapiens	20-23
30709319-0	2019	O2 reduction on a Au film electrode in an ionic liquid in the absence and presence of Mg2+ ions: Product formation and adlayer dynamics.	Oxygen	0-2	mucin 7, secreted	Homo sapiens	86-89
27989750-7	2016	We also observe an UCP2-dependent decrease in mtOXPHOS complex I (NADH dehydrogenase), complex IV (cytochrome c oxidase), complex V (ATPase) and in mitochondrial oxygen consumption, suggesting a role for UCP2 in the counteraction of pancreatic cancer cellular respiration.	Oxygen	162-168	uncoupling protein 2	Homo sapiens	19-23
30391318-0	2019	Effect of hyperbaric oxygen therapy on HMGB1/NF-kappaB expression and prognosis of acute spinal cord injury: A randomized clinical trial.	Oxygen	21-27	high mobility group box 1	Homo sapiens	39-44
27637078-8	2016	Furthermore, restoration of A20 in miR-125b-overexpressing cells decreased the CD4-negative population in T cell leukemia, and decreased glucose uptake and oxygen consumption to the basal level of T cells transfected with vector.	Oxygen	156-162	TNF alpha induced protein 3	Homo sapiens	28-31
30560652-4	2019	A combined experimental and first-principles study reveals that carbon interstitials (CiB) and oxygen vacancies (VO) form CiB-VO pairs which stabilize the tetragonal phase and enhance saturation magnetization.	Oxygen	95-101	calcium and integrin binding 1	Homo sapiens	122-125
27876792-5	2016	Accordingly, mTORC1 loss reduces oxygen consumption and causes a severe defect in BAT oxidative metabolism upon cold exposure.	Oxygen	33-39	CREB regulated transcription coactivator 1	Mus musculus	13-19
30547570-3	2019	Mixed-valence Ba2Fe2(PO4)F6 (II) possessed a three-dimensional framework containing Fe4O6F12 tetramers formed by the edge-sharing oxygen or fluorine atoms of cis-FeF4O2 octahedra.	Oxygen	130-136	folliculogenesis specific bHLH transcription factor	Homo sapiens	21-27
27748113-7	2016	Moreover, CO up-regulation during oxygen-glucose deprivation/reperfusion (OGD/R) was also imaged and certified by ACP-2.	Oxygen	34-40	acid phosphatase 2, lysosomal	Homo sapiens	114-119
30580569-3	2019	AQP1 (aquaporin-1) is regulated by oxygen level and has been observed to play a role in the proliferation and migration of pulmonary artery smooth muscle cells.	Oxygen	35-41	aquaporin 1	Mus musculus	0-4
27852364-7	2016	The level of MIF was associated positively with the apnea hypoventilation index (AHI, r=0.365, P=0.008) and the oxygen index reduction (ODI, r=0.308, P=0.308) n but negatively with the lowest blood oxygen (r=0.323, P=0.323).	Oxygen	112-118	macrophage migration inhibitory factor	Homo sapiens	13-16
27852364-7	2016	The level of MIF was associated positively with the apnea hypoventilation index (AHI, r=0.365, P=0.008) and the oxygen index reduction (ODI, r=0.308, P=0.308) n but negatively with the lowest blood oxygen (r=0.323, P=0.323).	Oxygen	198-204	macrophage migration inhibitory factor	Homo sapiens	13-16
30580569-3	2019	AQP1 (aquaporin-1) is regulated by oxygen level and has been observed to play a role in the proliferation and migration of pulmonary artery smooth muscle cells.	Oxygen	35-41	aquaporin 1	Mus musculus	6-17
31038579-9	2019	The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity.	Oxygen	78-84	COPD	Homo sapiens	15-19
27829441-9	2016	RESULTS: Under hypoxic conditions (i.e. 1 % O2), ICAR cell migration and proliferation was decreased (~20 and ~32 %, respectively) and apoptotic protein caspase-3 activation was increased (~1.6 fold).	Oxygen	44-46	caspase 3	Bos taurus	153-162
31804046-1	2019	BACKGROUND/AIMS: We have previously shown that inhibition of the mitochondrial Kv1.3 channel results in an initial mitochondrial hyperpolarization and a release of oxygen radicals that mediate mitochondrial depolarization, cytochrome c release and death.	Oxygen	164-170	potassium voltage-gated channel subfamily A member 3	Homo sapiens	79-84
27728765-2	2016	The as-prepared PorMOF was characterized with scanning electron microscopy, powder X-ray diffraction, and spectroscopic techniques and demonstrated excellent electrocatalytic activity toward O2 reduction.	Oxygen	191-193	lysine acetyltransferase 8	Homo sapiens	16-22
30625496-4	2019	In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mphi function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment.	Oxygen	170-176	microRNA 183	Mus musculus	55-62
27614828-12	2016	Frequency of genotypes for HSPA1L was affected by oxygen concentration and temperature, with an increase in the D allele for blastocysts that developed in high oxygen and following heat shock.	Oxygen	50-56	heat shock 70 kDa protein 1-like	Bos taurus	27-33
27614828-12	2016	Frequency of genotypes for HSPA1L was affected by oxygen concentration and temperature, with an increase in the D allele for blastocysts that developed in high oxygen and following heat shock.	Oxygen	160-166	heat shock 70 kDa protein 1-like	Bos taurus	27-33
30625496-4	2019	In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mphi function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment.	Oxygen	170-176	microRNA 183	Mus musculus	79-86
30475358-3	2018	Using X-ray photoelectron spectroscopy, electron spin resonance, magnetization measurements and other techniques, we concluded that immersing Ti3C2Tx MLs in the reducing agent Li-ethylenediamine (Li-EDA) - held at temperatures varying from room to 120  C - reduces the 2D layers creating Ti3+ ions and oxygen vacancies.	Oxygen	302-308	ectodysplasin A	Homo sapiens	199-202
27696837-7	2016	This oxidative regeneration/CO2 production step is subject to an apparent activation energy (Eapp) of 56.5 (+-5) kJ mol-1, is kinetically limited by the desorption of molecular CO from Pt nanoparticles, and also is shown to be dependent upon the partial pressure of O2 present in the oxidizing half of the cycle that we associate with the direct interaction of O2 with molecular CO adsorbed on the nanoparticles that promotes their desorption.	Oxygen	29-31	E2F associated phosphoprotein	Homo sapiens	93-97
27696837-7	2016	This oxidative regeneration/CO2 production step is subject to an apparent activation energy (Eapp) of 56.5 (+-5) kJ mol-1, is kinetically limited by the desorption of molecular CO from Pt nanoparticles, and also is shown to be dependent upon the partial pressure of O2 present in the oxidizing half of the cycle that we associate with the direct interaction of O2 with molecular CO adsorbed on the nanoparticles that promotes their desorption.	Oxygen	266-268	E2F associated phosphoprotein	Homo sapiens	93-97
27510308-1	2016	The PERCA (PEroxy Radical Chemical Amplification) technique, which is based on the catalytic conversion of ambient peroxy radicals (HO2 and RO2, where R stands for any organic chain) to a larger amount of nitrogen dioxide (NO2) amplified by chain reactions by adding high concentrations of NO and CO in the flow reactor, has been widely used for total peroxy radical RO2* (RO2* = HO2 + SigmaRO2) measurements.	Oxygen	115-129	heme oxygenase 2	Homo sapiens	132-135
27510308-1	2016	The PERCA (PEroxy Radical Chemical Amplification) technique, which is based on the catalytic conversion of ambient peroxy radicals (HO2 and RO2, where R stands for any organic chain) to a larger amount of nitrogen dioxide (NO2) amplified by chain reactions by adding high concentrations of NO and CO in the flow reactor, has been widely used for total peroxy radical RO2* (RO2* = HO2 + SigmaRO2) measurements.	Oxygen	115-129	heme oxygenase 2	Homo sapiens	380-383
27725978-6	2016	At the same time, the doping with alkali ions also promotes the formation of oxygen vacancies in STO, a prerequisite for effective oxide diffusion.	Oxygen	77-83	nuclear receptor binding SET domain protein 1	Homo sapiens	97-100
30342005-12	2018	Finally, inhibition of YAP alleviated retinal pathological neovascularization in mouse oxygen-induced retinopathy (OIR) model.	Oxygen	87-93	yes-associated protein 1	Mus musculus	23-26
27589845-3	2016	We were able to show that low oxygen concentrations consistently lead to the upregulation of miR-210 in different primary TIC-enriched cultures.	Oxygen	30-36	microRNA 210	Homo sapiens	93-100
30576195-1	2018	We report an observation of a quantum tunneling effect in a proton-transfer (PT) during potential-induced transformation of dioxygen on a platinum electrode in a low overpotential (eta) region at 298 K. However, this quantum process is converted to the classical PT scheme in the high eta region.	Oxygen	124-132	endothelin receptor type A	Homo sapiens	181-184
27421179-4	2016	Here, we report a small-molecular inhibitor of nNOS-PSD-95 interaction, SCR-4026, which exhibits neuroprotective activities in NMDA-induced or Oxygen and glucose deprivation (OGD)-induced neuronal damage in primary cortical neurons cultures, and ameliorated focal cerebral ischemic damage in rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion.	Oxygen	143-149	discs large MAGUK scaffold protein 4	Rattus norvegicus	52-58
27633102-8	2016	mTORC1 integrates cues such as nutrients, growth factors, oxygen, and energy to regulate growth of bone, skeletal muscle, nervous system, gastrointestinal tract, hematopoietic cells, immune effector cells, organ size, and whole-body energy balance.	Oxygen	58-64	CREB regulated transcription coactivator 1	Mus musculus	0-6
30576195-1	2018	We report an observation of a quantum tunneling effect in a proton-transfer (PT) during potential-induced transformation of dioxygen on a platinum electrode in a low overpotential (eta) region at 298 K. However, this quantum process is converted to the classical PT scheme in the high eta region.	Oxygen	124-132	endothelin receptor type A	Homo sapiens	285-288
27295323-5	2016	With the increasing in RE ionic radius (r), the SnO bond strength in Ln2Sn2O7 pyrochlores evaluated from the stretching IR band was decreased, resulting in the improved reducibility and enhanced oxygen vacancies of catalysts.	Oxygen	195-201	strawberry notch homolog 1	Homo sapiens	48-51
27521459-0	2016	Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy.	Oxygen	79-85	cytochrome b-245, beta polypeptide	Mus musculus	60-75
30576195-3	2018	This observation indicates that the quantum tunneling governs the multistep electron-proton-driven transformation of dioxygen in the low eta condition.	Oxygen	117-125	endothelin receptor type A	Homo sapiens	137-140
31762681-2	2018	Reactive oxygen species, which are produced from PCBs, alter blood-brain barrier (BBB) integrity, which is paralleled by cytoskeletal rearrangements and redistribution and disappearance of tight junction proteins (TJPs) like claudin-5 and occludin.	Oxygen	9-15	claudin 5	Rattus norvegicus	225-234
27499160-3	2016	Since Malat1 was recently shown to be upregulated during hypoxia, the objective of this study was to determine the contribution of AMPK in the mechanistic pathways regulating Malat1 expression in low oxygen conditions.	Oxygen	200-206	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	131-135
27499160-6	2016	Interestingly, pharmacological stimulation of AMPK increased Malat1 promoter transactivation in 21% O2 conditions, whereas inhibition of either AMPK or its upstream activator CaMKK completely abolished the augmentation of Malat1 under hypoxia.	Oxygen	100-102	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	46-50
27656164-6	2016	In all three "single-quinone" E. coli strains transitions in the activity of ArcB are observed, as evidenced by changes in the level of phosphorylation of the response regulator ArcA, upon depletion/readmission of oxygen.	Oxygen	214-220	arginine deiminase	Escherichia coli	178-182
31762681-2	2018	Reactive oxygen species, which are produced from PCBs, alter blood-brain barrier (BBB) integrity, which is paralleled by cytoskeletal rearrangements and redistribution and disappearance of tight junction proteins (TJPs) like claudin-5 and occludin.	Oxygen	9-15	occludin	Rattus norvegicus	239-247
27188792-3	2016	Recent studies have revealed that TUBB3 is also involved in an adaptive response to a microenvironmental stressor, e.g. low oxygen levels and poor nutrient supply in some solid tumors, independently of the microtubule targeting agent.	Oxygen	124-130	tubulin beta 3 class III	Homo sapiens	34-39
29504250-16	2018	CONCLUSION: The hyperbaric oxygen can up-regulate bax/bcl-2 value, increase the cell apoptosis rate, and inhibit the early hypertrophic scar in rabbit ears.	Oxygen	27-33	apoptosis regulator BAX	Oryctolagus cuniculus	50-53
27422454-14	2016	In vitro experiments revealed that the total amount of released HMGB1 into the culture medium of empty capsule (200 capsules/dish) and microencapsulated NPI (200 IEQ/dish) after hypoxic culture (1% O2 , 5% CO2 , and 94% N2 ) was 0 and 8.6 +- 2.2 ng, respectively (P &lt; 0.001).	Oxygen	198-200	high mobility group box 1	Mus musculus	64-69
27248356-0	2016	Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose deprivation-induced injury through bradykinin B2 receptor-dependent regulation of autophagy induction.	Oxygen	58-64	kallikrein 1	Homo sapiens	0-17
27248356-3	2016	To validate this hypothesis, we investigated TK-induced autophagy and its signaling mechanisms in human SH-SY5Y cells exposed to oxygen and glucose deprivation (OGD).	Oxygen	129-135	kallikrein 1	Homo sapiens	45-47
30377944-9	2018	The suppression occurred within 2 weeks when AAV-vectored hFlt3L was administered either before or after the transplantation of CD34+ progenitor cells, which was likely associated with the induction of murine myeloid-derived immune suppressive cells and reactive oxygen species in NSG-huCD34 mice.	Oxygen	263-269	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	58-64
26452362-8	2016	Cell culture studies disclosed enhanced metalloproteinase-9 secretion in supernatants derived from microglia of PI3Kgamma-deficient mice after 2-h oxygen/glucose deprivation and 48-h recovery.	Oxygen	147-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	112-121
26452362-10	2016	Lastly, PI3Kgamma-deficient microglia exhibited strongly increased cAMP levels in comparison with wild-type microglia or cells expressing kinase-dead PI3Kgamma after oxygen/glucose deprivation and recovery.	Oxygen	166-172	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	8-17
27170156-6	2016	In the brain, in microvascular endothelial cells, bFGF treatment increased the levels of junction proteins, caveolin-1 small interfering RNA abolished the protective effect of bFGF under oxygen-glucose deprivation conditions, and the expression of fibroblast growth factor receptor 1 and co-localization with caveolin-1 decreased significantly, which could not be reversed by bFGF treatment.	Oxygen	187-193	fibroblast growth factor 2	Rattus norvegicus	50-54
27441526-2	2016	Using synchrotron-based time-resolved VUV photoionization mass spectrometry, we probe numerous transient intermediates and products at P = 10-2000 Torr and T = 400-700 K. A key reaction sequence, revealed by our experiments, is the conversion of THF-yl peroxy to hydroperoxy-THF-yl radicals (QOOH), followed by a second O2 addition and subsequent decomposition to dihydrofuranyl hydroperoxide + HO2 or to gamma-butyrolactone hydroperoxide + OH.	Oxygen	320-322	heme oxygenase 2	Homo sapiens	395-398
27601891-0	2016	Automated oxygen titration and weaning with FreeO2 in patients with acute exacerbation of COPD: a pilot randomized trial.	Oxygen	10-16	COPD	Homo sapiens	90-94
27559166-5	2016	In a mouse model of oxygen-induced retinopathy, mimicking proliferative DR, p75(NTR)-dependent inflammation leads to ischemia and pathological angiogenesis through Semaphorin 3A.	Oxygen	20-26	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	164-177
30680255-2	2018	Introduction Published national guidelines on chronic obstructive pulmonary disease (COPD) highlight the importance of oxygen therapy, bronchodilators, corticosteroids, and appropriate antibiotics during acute exacerbations of COPD (AECOPD).	Oxygen	119-125	COPD	Homo sapiens	85-89
27342561-6	2016	The ompW gene, encoding a small outer membrane porin, has 40-fold higher expression during oxygen limitation, and it is proposed that OmpW plays a role in cation transport to maintain electrical neutrality during electron transfer.	Oxygen	91-97	outer membrane protein OmpW	Shewanella oneidensis MR-1	4-8
27489163-7	2016	Treatment of Ffar4 agonist (GW9508) recapitulated the thermogenic activation of EPA by increasing oxygen consumption rate, brown-specific marker genes, and miR-30b and 378, which were abrogated in Ffar4-silenced cells.	Oxygen	98-104	free fatty acid receptor 4	Mus musculus	13-18
27502280-3	2016	The major hypoxia-sensing component of the HIF system involves oxygen-dependent catalysis by the HIF hydroxylases; in humans there are three HIF prolyl hydroxylases (PHD1-3) and an asparaginyl hydroxylase (factor-inhibiting HIF (FIH)).	Oxygen	63-69	egl-9 family hypoxia inducible factor 2	Homo sapiens	166-172
27342561-6	2016	The ompW gene, encoding a small outer membrane porin, has 40-fold higher expression during oxygen limitation, and it is proposed that OmpW plays a role in cation transport to maintain electrical neutrality during electron transfer.	Oxygen	91-97	outer membrane protein OmpW	Shewanella oneidensis MR-1	134-138
30680255-2	2018	Introduction Published national guidelines on chronic obstructive pulmonary disease (COPD) highlight the importance of oxygen therapy, bronchodilators, corticosteroids, and appropriate antibiotics during acute exacerbations of COPD (AECOPD).	Oxygen	119-125	COPD	Homo sapiens	227-231
30318547-4	2018	Peaks at 9.6 and 9.9 eV in the spectra of both compounds, previously associated with the removal of an electron from the lone pair level of the equatorial oxygens, should actually be assigned to the bonding orbital HV1 of their 3c-4e axial CSi N moiety.	Oxygen	155-162	hydrogen voltage gated channel 1	Homo sapiens	215-218
27559317-0	2016	Maximal Oxygen Consumption Is Reduced in Aquaporin-1 Knockout Mice.	Oxygen	8-14	aquaporin 1	Mus musculus	41-52
27077479-7	2016	Direct measurement of FAO in the WD-fed BMPR2-mutant RV showed impaired palmitate-linked oxygen consumption, and metabolomics analysis showed reduced indices of FAO.	Oxygen	89-95	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	40-45
30486925-6	2018	Improving the dissolved oxygen concentration in AE1 eliminated the negative effect of increased organic loading on nitrification, but it affected the stability of nitrosation.	Oxygen	24-30	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	48-51
27484797-0	2016	Blue Light-excited Light-Oxygen-Voltage-sensing Domain 2 (LOV2) Triggers a Rearrangement of the Kinase Domain to Induce Phosphorylation Activity in Arabidopsis Phototropin1.	Oxygen	25-31	phototropin 1	Arabidopsis thaliana	160-172
27699105-2	2016	Vis-OCT can retrieve blood oxygen saturation (sO2) mapping using intrinsic optical absorption contrast while providing high-resolution anatomical vascular structures at the same time.	Oxygen	27-33	plexin A2	Mus musculus	4-7
27489958-0	2016	Fzd4 Haploinsufficiency Delays Retinal Revascularization in the Mouse Model of Oxygen Induced Retinopathy.	Oxygen	79-85	frizzled class receptor 4	Mus musculus	0-4
27629362-7	2016	Because the reduction potential of oxygen is more positive [E(0) (O2/H2O) = 1.23 V vs. NHE] than common catholytes (e.g., iodide, sulfur), a high discharge voltage is produced.	Oxygen	35-41	solute carrier family 9 member C1	Homo sapiens	87-90
30351132-0	2018	Electrocatalytic Study of the Oxygen Reduction Reaction at Gold Nanoparticles in the Absence and Presence of Interactions with SnO x Supports.	Oxygen	30-36	strawberry notch homolog 1	Homo sapiens	127-130
27652091-0	2016	Effects and mechanisms of docosahexaenoic acid on the generation of angiopoietin-2 by rat brain microvascular endothelial cells under an oxygen- and glucose-deprivation environment.	Oxygen	137-143	angiopoietin 2	Rattus norvegicus	68-82
27418140-5	2016	Pharmacological inhibition of NOX1 using apocynin (pan-NOX inhibitor), ML171 (NOX1 inhibitor) or siRNA against NOX1 prevents the increases in O2.- and H2O2 levels and the anti-proliferative effect of cambogin.	Oxygen	142-144	NADPH oxidase 1	Homo sapiens	30-34
27418140-5	2016	Pharmacological inhibition of NOX1 using apocynin (pan-NOX inhibitor), ML171 (NOX1 inhibitor) or siRNA against NOX1 prevents the increases in O2.- and H2O2 levels and the anti-proliferative effect of cambogin.	Oxygen	142-144	NADPH oxidase 1	Homo sapiens	78-82
27418140-5	2016	Pharmacological inhibition of NOX1 using apocynin (pan-NOX inhibitor), ML171 (NOX1 inhibitor) or siRNA against NOX1 prevents the increases in O2.- and H2O2 levels and the anti-proliferative effect of cambogin.	Oxygen	142-144	NADPH oxidase 1	Homo sapiens	78-82
27652091-1	2016	OBJECTIVE: The aim of this study was to investigate the effects of docosahexaenoic acid (DHA) on the generation of angiopoietin-2 (Ang-2) by rat brain microvascular endothelial cells under an oxygen- and glucose-deprivation environment (OGD), and its relationship, if any, with cyclooxygenase 2 (COX-2) expression.	Oxygen	192-198	angiopoietin 2	Rattus norvegicus	115-129
30351132-1	2018	Here we report that density functional theory (DFT) can be used to accurately predict how Au nanoparticle (NP) catalysts cooperate with SnO x ( x = 1.9 or 2.0) supports to carry out the oxygen reduction reaction (ORR).	Oxygen	186-192	strawberry notch homolog 1	Homo sapiens	136-139
27652091-1	2016	OBJECTIVE: The aim of this study was to investigate the effects of docosahexaenoic acid (DHA) on the generation of angiopoietin-2 (Ang-2) by rat brain microvascular endothelial cells under an oxygen- and glucose-deprivation environment (OGD), and its relationship, if any, with cyclooxygenase 2 (COX-2) expression.	Oxygen	192-198	angiopoietin 2	Rattus norvegicus	131-136
26829052-3	2016	mTORC1 is critical to link protein synthesis activity to nutrient and oxygen levels, in part by controlling the 4E-BP1-eIF4E axis.	Oxygen	70-76	CREB regulated transcription coactivator 1	Mus musculus	0-6
26829052-3	2016	mTORC1 is critical to link protein synthesis activity to nutrient and oxygen levels, in part by controlling the 4E-BP1-eIF4E axis.	Oxygen	70-76	eukaryotic translation initiation factor 4E	Homo sapiens	119-124
27367435-5	2016	A formation of the oxidized oxygen species upon electrochemical Li extraction coincides with transformation of the layered Li1-xRhO2 structure into the gamma-MnO2-type rutile-ramsdellite intergrowth LiyRh3O6 structure with rutile-like [1 x 1] channels along with bigger ramsdellite-like [2 x 1] tunnels through massive and concerted Rh migration toward the empty positions in the Li layers.	Oxygen	28-34	transglutaminase 1	Homo sapiens	123-126
27417539-3	2016	Mouse genetic studies show that elevated erythrocyte Sphk1-induced S1P protects against tissue hypoxia by inducing O2 release.	Oxygen	115-117	sphingosine kinase 1	Mus musculus	53-58
30443183-3	2018	Firstly, we demonstrated that miR-186-5p were significantly up-regulated and induced apoptosis in oxygen and glucose deprivation/reperfusion (OGD/R) model.	Oxygen	98-104	microRNA 186	Homo sapiens	30-37
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Oxygen	89-95	aquaporin 1	Mus musculus	57-68
27383386-7	2016	Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel.	Oxygen	89-95	aquaporin 1	Mus musculus	70-74
27272616-4	2016	We investigated the differential effect of feedback, explicit instructions and monetary reward while training healthy individuals to up-regulate the blood-oxygen-level dependent (BOLD) signal in the supplementary motor area (SMA).	Oxygen	155-161	survival of motor neuron 1, telomeric	Homo sapiens	225-228
30299092-2	2018	In this study, we report results on the deactivation of O2( a1Deltag, v = 1-3) in collisions with O2 and CO2.	Oxygen	56-58	immunoglobulin kappa variable 1-5	Homo sapiens	70-75
27525436-4	2016	FYN and NOX4 colocalized in perinuclear mitochondria, ER, and nuclear fractions in CMs, and FYN expression negatively regulated NOX4-induced O2- production and apoptosis in CMs.	Oxygen	141-143	NADPH oxidase 4	Mus musculus	128-132
27191352-4	2016	Using small hydrogel bricks with oxygen distribution equal to the microchanneled configuration, this study demonstrates that among different culture conditions, co-culture of mesenchymal and endothelial cells supplemented with ANG-1 and VEGF leads to the most developed vascular network.	Oxygen	33-39	angiopoietin 1	Homo sapiens	227-232
30299092-2	2018	In this study, we report results on the deactivation of O2( a1Deltag, v = 1-3) in collisions with O2 and CO2.	Oxygen	98-100	immunoglobulin kappa variable 1-5	Homo sapiens	70-75
27221116-7	2016	Furthermore, respiration rates of intact cells deficient for Nr4a1 or Nr4a3 in the presence of 16 mM glucose resulted in decreased glucose mediated oxygen consumption.	Oxygen	148-154	nuclear receptor subfamily 4, group A, member 3	Mus musculus	70-75
29620819-1	2016	We report, for the first time, hemoglobin (Hb) Lansing-Ramathibodi[alpha87(F8)His   Gln; CAC&gt;CAG (HBA1: c.264C&gt;G)] in four members of a Thaifamily presented with low measured oxygen saturation by pulse oximetry (SpO2),with discrepancy between low SpO2 and normal calculated oxygen saturation byarterial blood gas analysis, and no cyanosis or methemoglobinemia.	Oxygen	181-187	hemoglobin subunit alpha 1	Homo sapiens	101-105
30299092-4	2018	Deactivation of the a( v = 1-3) levels in collisions with O2 at 300 K is fast, with rate coefficients of (5.6 +- 1.1) x 10-11, (3.6 +- 0.4) x 10-11, and (1.9 +- 0.4) x 10-11 cm3 s-1 (2sigma) for v = 1, 2, and 3, respectively.	Oxygen	58-60	immunoglobulin kappa variable 1-5	Homo sapiens	23-28
29620819-1	2016	We report, for the first time, hemoglobin (Hb) Lansing-Ramathibodi[alpha87(F8)His   Gln; CAC&gt;CAG (HBA1: c.264C&gt;G)] in four members of a Thaifamily presented with low measured oxygen saturation by pulse oximetry (SpO2),with discrepancy between low SpO2 and normal calculated oxygen saturation byarterial blood gas analysis, and no cyanosis or methemoglobinemia.	Oxygen	280-286	hemoglobin subunit alpha 1	Homo sapiens	101-105
30299092-4	2018	Deactivation of the a( v = 1-3) levels in collisions with O2 at 300 K is fast, with rate coefficients of (5.6 +- 1.1) x 10-11, (3.6 +- 0.4) x 10-11, and (1.9 +- 0.4) x 10-11 cm3 s-1 (2sigma) for v = 1, 2, and 3, respectively.	Oxygen	58-60	immunoglobulin kappa variable 1-5	Homo sapiens	195-210
30328811-5	2018	Our data suggest that the pleiotropic effects of glb-5 and npr-1 are a consequence of changes to O2 -sensing neurons that regulate both aerotaxis and energy homeostasis.	Oxygen	97-99	GLOBIN domain-containing protein	Caenorhabditis elegans	49-54
27339894-0	2016	Mechanism of 17alpha,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.	Oxygen	110-116	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	71-91
27339894-0	2016	Mechanism of 17alpha,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.	Oxygen	162-168	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	71-91
27551674-12	2016	Thus, bFGF can significantly decrease the risk of root resorption by providing more oxygen and angiogenesis.	Oxygen	84-90	fibroblast growth factor 2	Rattus norvegicus	6-10
27207533-3	2016	Overexpression of dnATF6 or small interfering RNA-mediated knockdown of ATF6 decreases the transcriptional activity of peroxisome proliferator-activated receptor alpha (PPARalpha)/retinoid X receptor complex, and inhibits oxygen consumption rates in hepatocytes, possibly through inhibition of the binding of PPARalpha to the promoter of its target gene.	Oxygen	222-228	activating transcription factor 6	Mus musculus	20-24
30349321-3	2018	Materials and methods: CA IX expression in SaOS2 cells cultured under different oxygen tensions was analyzed by Western blotting.	Oxygen	80-86	carbonic anhydrase 9	Homo sapiens	23-28
26689275-3	2016	The authors hypothesized positive correlations between blood oxygen level-dependent functional magnetic resonance imaging (fMRI) activation in brain regions related to auditory language processing and attention and scores on the Clinical Evaluation of Language Fundamentals-Preschool, Second Edition (CELF-P2) and the Early Speech Perception Test for Profoundly Hearing-Impaired Children (ESP), in children with congenital hearing loss.	Oxygen	61-67	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	389-392
27121290-5	2016	Low levels of glucose and oxygen stimulated AMP-activated kinase (AMPK) in glioma cells.	Oxygen	26-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	44-64
27121290-5	2016	Low levels of glucose and oxygen stimulated AMP-activated kinase (AMPK) in glioma cells.	Oxygen	26-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	66-70
26588041-0	2016	Nuclear Factor kappaB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels.	Oxygen	96-102	RELA proto-oncogene, NF-kB subunit	Homo sapiens	23-27
26588041-8	2016	RelA knockdown prevented the upregulation of the pro-inflammatory cytokines at 21% O2, suggesting NF-kappaB1/RelA as a major mediator of inflammatory response in cells cultured at 21% O2.	Oxygen	83-85	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-4
26588041-8	2016	RelA knockdown prevented the upregulation of the pro-inflammatory cytokines at 21% O2, suggesting NF-kappaB1/RelA as a major mediator of inflammatory response in cells cultured at 21% O2.	Oxygen	184-186	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-4
27214555-7	2016	Indeed, compared with control animals, oxygen consumption in the kidneys of claudin-2-null mice was markedly increased, resulting in medullary hypoxia.	Oxygen	39-45	claudin 2	Mus musculus	76-85
26471784-7	2016	State 3 increased from 20.6 (17.9-28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0-49.0), p = 0.01, while state 4 increased from 2.8 (1.8-4.2) to 4.2 nmol O2/min/U CS (3.1-6.1), although not statistically significant.	Oxygen	53-55	citrate synthase	Homo sapiens	62-78
26471784-7	2016	State 3 increased from 20.6 (17.9-28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0-49.0), p = 0.01, while state 4 increased from 2.8 (1.8-4.2) to 4.2 nmol O2/min/U CS (3.1-6.1), although not statistically significant.	Oxygen	53-55	citrate synthase	Homo sapiens	80-82
26780539-10	2016	The apparent P50 (oxygen tension at which hemoglobin is 50% saturated) value was derived from the curves, calculated as the R1 scaled value (x) at which the change in R2* divided by R2*at baseline scaled (y) equals 0.5.	Oxygen	18-24	dynactin 2	Mus musculus	13-16
27323252-3	2016	In pure 1 M KOH electrolyte, the optimized catalyst, which had an Ir:Ni atom ratio of 1:1.49, could catalyze 10 mA/cm(2) of O2 production at a small overpotential (eta) of 264 mV.	Oxygen	124-126	endothelin receptor type A	Homo sapiens	164-167
26822739-8	2016	Cox regression analysis revealed statistical significance for the Brinkman Index, the ratio of the pulmonary artery diameter to the ascending aorta diameter (PA:A), and the alveolar-arterial oxygen gradient.	Oxygen	191-197	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
27366678-1	2016	AIM: To investigate the signal transduction mechanism of matrix metalloproteinase-9 (MMP-9) mediated- vascular endothelial growth factor (VEGF) expression and retinal neovascularization (RNV) in oxygen-induced retinopathy (OIR) model.	Oxygen	195-201	matrix metallopeptidase 9	Mus musculus	57-83
27366678-1	2016	AIM: To investigate the signal transduction mechanism of matrix metalloproteinase-9 (MMP-9) mediated- vascular endothelial growth factor (VEGF) expression and retinal neovascularization (RNV) in oxygen-induced retinopathy (OIR) model.	Oxygen	195-201	matrix metallopeptidase 9	Mus musculus	85-90
26819450-12	2016	Inactivation of HIF1/NDUFA4L2 increased mitochondrial activity and oxygen consumption, resulting in ROS accumulation and apoptosis.	Oxygen	67-73	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	21-29
27247382-4	2016	Here, we use live-cell imaging to demonstrate that OPTN, NDP52, and TAX1BP1 are recruited to mitochondria with similar kinetics following either mitochondrial depolarization or localized generation of reactive oxygen species, leading to sequestration by the autophagosome within ~45 min after insult.	Oxygen	210-216	calcium binding and coiled-coil domain 2	Homo sapiens	57-62
27265727-4	2016	Mechanistically, p53 activation represses the expression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of the TCA cycle intermediates oxaloacetate and NADPH, and impaired oxygen consumption.	Oxygen	215-221	pyruvate carboxylase	Mus musculus	85-105
27183144-2	2016	High-resolution AFM images obtained with metallic tips show clear contrasts between oxygen atoms and phenyl moieties.	Oxygen	84-90	afamin	Homo sapiens	16-19
26764207-3	2016	We aimed to investigate how diabetes and SGLT2 inhibition affect TNa and sodium transport-dependent oxygen consumption [Formula: see text] along the whole nephron.	Oxygen	100-106	solute carrier family 5 member 2	Rattus norvegicus	41-46
27163880-1	2016	A concerted HO2 loss reaction from a peroxy radical (RO2), formed from the addition of O2 to an alkyl radical, has been proposed as a mechanism to form closed-shell products in the atmospheric oxidation of organic molecules.	Oxygen	37-51	heme oxygenase 2	Homo sapiens	12-15
27219009-2	2016	While it was recently shown that PEDF expression is inhibited under low oxygen conditions, the functional role of PEDF in response to hypoxia/reoxygenation (H/R) remains unclear.	Oxygen	72-78	serpin family F member 1	Homo sapiens	33-37
27140863-3	2016	Very little HO2(+) is seen from the reaction of H3(+) with O2, which is attributed to an efficient secondary reaction between HO2(+) and H2.	Oxygen	13-15	heme oxygenase 2	Homo sapiens	126-129
27106929-5	2016	After loss of frataxin protein, cell division, aconitase activity and oxygen consumption rates were found to be decreased, while ROS production was increased in the homozygous state.	Oxygen	70-76	frataxin	Homo sapiens	14-22
26620126-1	2016	Von Hippel-Lindau (VHL) is an onco-suppressor involved in oxygen and energy-dependent promotion of protein ubiquitination and proteosomal degradation.	Oxygen	58-64	von Hippel-Lindau tumor suppressor	Homo sapiens	19-22
26799785-3	2016	Here, we assess the impact of germline heterozygosity of a novel, oxygen-independent ubiquitin ligase for HIF-1alpha: hypoxia-associated factor (HAF; encoded by SART1).	Oxygen	66-72	squamous cell carcinoma antigen recognized by T cells 1	Mus musculus	118-143
26799785-3	2016	Here, we assess the impact of germline heterozygosity of a novel, oxygen-independent ubiquitin ligase for HIF-1alpha: hypoxia-associated factor (HAF; encoded by SART1).	Oxygen	66-72	squamous cell carcinoma antigen recognized by T cells 1	Mus musculus	145-148
26799785-3	2016	Here, we assess the impact of germline heterozygosity of a novel, oxygen-independent ubiquitin ligase for HIF-1alpha: hypoxia-associated factor (HAF; encoded by SART1).	Oxygen	66-72	squamous cell carcinoma antigen recognized by T cells 1	Mus musculus	161-166
27235555-13	2016	In conclusion, our results support the hypothesis that CYP1B1 plays a mechanistic role in pulmonary oxygen toxicity, and CYP1B1-mediated apoptosis could be one of the mechanisms of oxygen toxicity.	Oxygen	181-187	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	121-127
27435470-5	2016	Among the samples, Ce20 Cr1 Ox exhibited the best catalytic performance, mainly because it has the best reducibility and more chemisorbed oxygen, and significant reasons for these attributes may be closely related to favorable synergistic interactions of the vacancies and near-surface Ce(3+) and Cr(3+) .	Oxygen	138-144	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	24-27
27155083-0	2016	Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis.	Oxygen	14-20	SMAD family member 2	Homo sapiens	108-113
27155083-0	2016	Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis.	Oxygen	14-20	Yes1 associated transcriptional regulator	Homo sapiens	118-121
27240426-1	2016	Hb Tarrant [alpha126(H9)Asp Asn; HBA2: c.379G &gt; A (or HBA1)], is a rare high oxygen affinity hemoglobin (Hb) variant that causes erythrocytosis, previously described in a few Mexican-American families.	Oxygen	80-86	hemoglobin subunit alpha 2	Homo sapiens	33-37
27435822-5	2016	Assessments of mitochondrial bioenergetics in the cortex of wild type (WT) and SIRT5-/- mice revealed that SIRT5 regulates oxygen consumption in the presence of complex I, complex II, and complex IV substrates.	Oxygen	123-129	sirtuin 5	Mus musculus	107-112
27007876-11	2016	Compared with gene expression levels at 5 % O2, which were arbitrarily set as "1," 20 % O2 is associated with significantly higher expression of BAX (2.14 +- 0.47), G6PD (2.92 +- 1.06), MnSOD (2.87 +- 0.88), and HSP70.1 (8.68 +- 4.19).	Oxygen	88-90	superoxide dismutase 2	Homo sapiens	186-191
27016099-1	2016	The review is dedicated to ascertainment of the roles of the electron transfer cofactors of the pigment-protein complex of PSI, ferredoxin (Fd) and ferredoxin-NADP reductase in oxygen reduction in the photosynthetic electron transport chain (PETC) in the light.	Oxygen	177-183	ferredoxin reductase	Homo sapiens	148-173
27345691-8	2016	Functional studies with Let-7i-5p mimic in human brite adipocytes in vitro revealed a decrease in the expression of UCP1 and in the oxygen consumption rate.	Oxygen	132-138	microRNA let-7i	Homo sapiens	24-30
27306619-4	2016	Here, we outline major oxygen friend or foes properties, which may partly explain the study results, and place the clinical trial from Smit et al.	Oxygen	23-29	solute carrier family 5 member 3	Homo sapiens	135-139
26941203-7	2016	Deregulation of p66(Shc) and JunD in aged EOCs led to up-regulation of NADPH oxidase, reduced expression of manganese superoxide dismutase (MnSOD) and increased O2 (-) generation.	Oxygen	161-163	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-33
26901395-1	2016	Important electromeric states in manganese-oxo porphyrins MnO(P)(+) and MnO(PF4)(+) (porphyrinato or meso-tetrafluoroporphyrinato) have been investigated with correlated ab initio methods (CASPT2, RASPT2), focusing on their possible role in multistate reactivity patterns in oxygen transfer (OAT) reactions.	Oxygen	275-281	platelet factor 4	Homo sapiens	76-79
27020861-3	2016	Using combined pharmacologic and genetic knockout approaches, we demonstrate that tamoxifen inhibits oxygen consumption via inhibition of mitochondrial complex I, resulting in an increase in the AMP/ATP ratio and activation of the AMP-activated protein kinase (AMPK) signaling pathway in vitro and in vivo AMPK in turn promotes glycolysis and alters fatty acid metabolism.	Oxygen	101-107	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	231-259
27020861-3	2016	Using combined pharmacologic and genetic knockout approaches, we demonstrate that tamoxifen inhibits oxygen consumption via inhibition of mitochondrial complex I, resulting in an increase in the AMP/ATP ratio and activation of the AMP-activated protein kinase (AMPK) signaling pathway in vitro and in vivo AMPK in turn promotes glycolysis and alters fatty acid metabolism.	Oxygen	101-107	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	306-310
26935109-6	2016	Clamp studies revealed that POMC-Ptp1b deletion reduced body fat and increased energy expenditure as evidenced by a decrease in feed efficiency and an increase in oxygen consumption and respiratory exchange ratio.	Oxygen	163-169	pro-opiomelanocortin-alpha	Mus musculus	28-32
26979919-5	2016	Pulse oximetry-measured oxygen saturation and serum lactate level were significantly correlated with dAo-RF ratio, but they had some clinical dispersion to match the postoperative adverse events.	Oxygen	24-30	down and out	Drosophila melanogaster	101-104
26613797-8	2016	Our results provide evidence that oxygen restriction promotes the expression of granulysin and suggest that this effect-in conjunction with additional T cell-mediated immune responses-supports protection against mycobacteria.	Oxygen	34-40	granulysin	Homo sapiens	80-90
26754561-1	2016	Mitochondrial cytochrome c oxidase utilizes electrons provided by cytochrome c for the active vectorial transport of protons across the inner mitochondrial membrane through the reduction of molecular oxygen to water.	Oxygen	200-206	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	14-34
26754561-1	2016	Mitochondrial cytochrome c oxidase utilizes electrons provided by cytochrome c for the active vectorial transport of protons across the inner mitochondrial membrane through the reduction of molecular oxygen to water.	Oxygen	200-206	LOC104968582	Bos taurus	14-26
27534108-2	2016	At least, three of them (1, 2 and 4) increased the functional activities of neutrophils, including levels of oxygen-dependent metabolism, adhesive and phagocytic properties, and induced the expression of pro-inflammatory cytokines TNF-alpha and IL-8.	Oxygen	109-115	acyl-CoA thioesterase 11	Mus musculus	19-35
27243218-9	2016	Oxygen radical absorbance capacity increased over time in AAC cows.	Oxygen	0-6	glycine N-acyltransferase	Bos taurus	58-61
27083257-9	2016	Oxygen moieties in organic cations decreased the affinity for C18/SCX-SPME.	Oxygen	0-6	scleraxis bHLH transcription factor	Homo sapiens	66-69
27002144-2	2016	Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2.	Oxygen	28-34	eukaryotic translation initiation factor 4E	Homo sapiens	76-81
27002144-2	2016	Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2.	Oxygen	28-34	eukaryotic translation initiation factor 4E	Homo sapiens	162-167
27002144-4	2016	This complex mediates cap-dependent translation under cell culture conditions of 1% oxygen (to mimic tumor microenvironments), whereas eIF4E mediates cap-dependent translation at 21% oxygen (ambient air).	Oxygen	183-189	eukaryotic translation initiation factor 4E	Homo sapiens	135-140
27002144-8	2016	The oxygen-dependent activities of eIF4E and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-dependent).	Oxygen	4-10	eukaryotic translation initiation factor 4E	Homo sapiens	35-40
27002144-8	2016	The oxygen-dependent activities of eIF4E and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-dependent).	Oxygen	4-10	eukaryotic translation initiation factor 4E	Homo sapiens	45-50
27002144-9	2016	We have identified oxygen conditions where eIF4E is the dominant cap-binding protein (21% normoxia or standard cell culture conditions), where eIF4E2 is the dominant cap-binding protein (1% hypoxia or ischemic diseases and cancerous tumors), and where both cap-binding proteins act simultaneously to initiate the translation of distinct mRNAs (1-11% physioxia or during development and stem cell differentiation).	Oxygen	19-25	eukaryotic translation initiation factor 4E	Homo sapiens	43-48
27101350-5	2016	Moreover, as a promising NiMn-based oxygen evolution reaction (OER) catalyst, the special sandwiched nanostructure demonstrates improved electrochemical properties in 1 M KOH, including a low overpotential of about 250 mV, a modest Tafel slope of 40 mV dec(-1), excellent stability over 2000 cycles, and durability for 40 h.	Oxygen	36-42	deleted in esophageal cancer 1	Homo sapiens	253-259
30044066-0	2016	[The effect of hyperbaric oxygen preconditioning on the expression of ICAM-1, VCAM-1, NF-kappaB and flap survival rate during ischemia-reperfusion injury in rat abdominal skin flap].	Oxygen	26-32	vascular cell adhesion molecule 1	Rattus norvegicus	78-84
30044066-1	2016	Objective: To evaluate the effect of hyperbaric oxygen preconditioning on the expression of intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1),NF-kappaB and flap survival rate during Ischemia-Reperfusion Injury in Rat Abdominal Skin Flap.	Oxygen	48-54	vascular cell adhesion molecule 1	Rattus norvegicus	135-168
30044066-10	2016	Conclusions: Hyperbaric oxygen preconditioning could decrease the expression of ICAM-1,VCAM-1,NF-kappaB and promote flap survival rate during the process of ischemia-reperfusion injury on a rat abdominal skin flap model.	Oxygen	24-30	vascular cell adhesion molecule 1	Rattus norvegicus	87-93
26921340-2	2016	Prolyl hydroxylase enzymes (PHD1-3) are molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions in metastatic disease remain unclear.	Oxygen	50-56	egl-9 family hypoxia inducible factor 2	Homo sapiens	28-34
26930163-7	2016	In vitro, using rat hippocampal cells, short-term oxygen/glucose deprivation induced preconditioning and RyR antagonists, dantrolene (50 and 100 muM) and ryanodine (100 and 200 muM) prevented it.	Oxygen	50-56	ryanodine receptor 2	Rattus norvegicus	105-108
27066464-15	2016	O2 requirements at ICU transfer positively correlated with day 7 MMP-8 (r = 0.85, p = 0.016) and Ang-2 levels (r = 0.79, p = 0.036) in the placebo group and inversely correlated with day 7 sICAM-1 levels (r = -0.91, p = 0.005) in the MPT group.	Oxygen	0-2	angiopoietin 2	Homo sapiens	97-102
27047516-8	2016	The oxygen-evolving complex may be disrupted in pgp1-2, which may accelerate the photodamage to PSII by red light.	Oxygen	4-10	P-glycoprotein 12	Arabidopsis thaliana	48-54
26708156-5	2016	RESULTS: BMP-2 is much more efficient to stimulate the expression of the cartilage-specific gene COL2A1 by HACs when cultured under hypoxia (1%O2) compared to normoxia (21%O2).	Oxygen	143-145	bone morphogenetic protein 2	Homo sapiens	9-14
26708156-5	2016	RESULTS: BMP-2 is much more efficient to stimulate the expression of the cartilage-specific gene COL2A1 by HACs when cultured under hypoxia (1%O2) compared to normoxia (21%O2).	Oxygen	172-174	bone morphogenetic protein 2	Homo sapiens	9-14
26891117-5	2016	This non-linear or hormesis response to oxygen was specific for the alveolar epithelium because low oxygen stimulated and high oxygen inhibited angiogenesis as defined by changes in V-cadherin and PECAM (CD31).	Oxygen	40-46	platelet/endothelial cell adhesion molecule 1	Mus musculus	197-202
26891117-5	2016	This non-linear or hormesis response to oxygen was specific for the alveolar epithelium because low oxygen stimulated and high oxygen inhibited angiogenesis as defined by changes in V-cadherin and PECAM (CD31).	Oxygen	40-46	platelet/endothelial cell adhesion molecule 1	Mus musculus	204-208
27128320-8	2016	UCP2 induction also increases the oxygen consumption and the "proton leak" in microvascular endothelial cells.	Oxygen	34-40	uncoupling protein 2	Homo sapiens	0-4
26444867-4	2016	Unexpectedly the mutant had a higher energy efficiency, indicated by a much lower rate of oxygen consumption, under glucose-limited conditions, caused by the deletion of the transcription factors IclR and ArcA.	Oxygen	90-96	arginine deiminase	Escherichia coli	205-209
29859163-3	2018	This facility equipped with O2 supply system enables the sub-millisecond time scale infrared measurements of the O2 reduction coupled with proton pumping by bovine cytochrome c oxidase (CcO) initiated by CO-flash photolysis in the COOH (1725-1770 cm-1) region with the accuracy of about 10 muO.D.	Oxygen	28-30	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	164-184
26854136-10	2016	Levels of ROS, Bax, caspase-3 and BACE were increased, whereas expression of Bcl-2 was decreased, in cells treated with 95% oxygen plus 2.4% isoflurane compared with the control and 2.4% isoflurane plus air groups.	Oxygen	124-130	caspase 3	Rattus norvegicus	20-29
26711740-4	2016	In addition, we unexpectedly found increased surface expression of HLA-E in human and Qa-1 in mouse tumor cells exposed to combined oxygen and glucose deprivation.	Oxygen	132-138	major histocompatibility complex, class I, E	Homo sapiens	67-72
26711740-4	2016	In addition, we unexpectedly found increased surface expression of HLA-E in human and Qa-1 in mouse tumor cells exposed to combined oxygen and glucose deprivation.	Oxygen	132-138	major histocompatibility complex, class I, E	Homo sapiens	86-90
26878205-2	2016	We first analyzed the unstrained system, and found that the induced polarization toward the vacuum in the LAO film leads to a small charge carrier density on the order of 10(13) cm(-2) (less than the theoretical value of 3.3 x 10(14) cm(-2) from the superlattice-model-based polar catastrophe mechanism), which is in excellent agreement with the experimental values of oxygen-annealed LAO/STO HS samples.	Oxygen	369-375	interleukin 4 induced 1	Homo sapiens	106-109
29859163-3	2018	This facility equipped with O2 supply system enables the sub-millisecond time scale infrared measurements of the O2 reduction coupled with proton pumping by bovine cytochrome c oxidase (CcO) initiated by CO-flash photolysis in the COOH (1725-1770 cm-1) region with the accuracy of about 10 muO.D.	Oxygen	28-30	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	186-189
26684249-7	2016	Physiologically deletion of TREM-1 conferred an immunometabolic advantage with low oxygen consumption rate (OCR) sparing the respiratory capacity of macrophages challenged with LPS.	Oxygen	83-89	triggering receptor expressed on myeloid cells 1	Mus musculus	28-34
29859163-3	2018	This facility equipped with O2 supply system enables the sub-millisecond time scale infrared measurements of the O2 reduction coupled with proton pumping by bovine cytochrome c oxidase (CcO) initiated by CO-flash photolysis in the COOH (1725-1770 cm-1) region with the accuracy of about 10 muO.D.	Oxygen	113-115	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	186-189
30213210-3	2018	We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1.	Oxygen	94-100	histone deacetylase 2	Rattus norvegicus	17-38
26525831-6	2016	OBJECTIVE: The aim of this study was to evaluate visfatin levels in preterm neonates resuscitated with different concentrations of oxygen in the delivery room.	Oxygen	131-137	nicotinamide phosphoribosyltransferase	Homo sapiens	49-57
26525831-8	2016	RESULTS: At T72 h and T168 h, higher serum visfatin values in the high-oxygen group compared to the low- and mild-oxygen subjects (P=0.002 and P&lt;0.001, respectively) were noted.	Oxygen	71-77	nicotinamide phosphoribosyltransferase	Homo sapiens	43-51
26846855-6	2016	These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL disease.	Oxygen	119-125	von Hippel-Lindau tumor suppressor	Homo sapiens	87-90
26690829-10	2016	Moreover, there was a non-linear association between GRIN2B genetic score and prefrontal activity, i.e. both high and low putative genetic score levels were associated with high blood oxygen level-dependent signals in the prefrontal cortex.	Oxygen	184-190	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	53-59
30213210-3	2018	We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1.	Oxygen	94-100	histone deacetylase 2	Rattus norvegicus	40-45
30156822-5	2018	Nevertheless, the interfacial Li+ ions also display changes of solvation from that in bulk SIL by deviating from the molecular plane formed by the oxygen atoms on G3 ligands as electrodes become more negatively charged.	Oxygen	147-153	STIL centriolar assembly protein	Homo sapiens	91-94
26980435-7	2016	AK4 knockdown cell showed a increased oxygen consumption rate with FCCP treatment, while AK4 overexpression lowered it.	Oxygen	38-44	adenylate kinase 4	Homo sapiens	0-3
26687331-1	2016	Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD(+) as electron acceptors.	Oxygen	150-152	xanthine dehydrogenase	Homo sapiens	6-29
26687331-1	2016	Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD(+) as electron acceptors.	Oxygen	150-152	xanthine dehydrogenase	Homo sapiens	31-34
26721561-6	2016	We observe that zebrafish Ngb and Cygb2 have comparable spectral features to those of human Ngb and Cygb, consistent with a six-coordinate heme, whereas unexpectedly Cygb1 has a five-coordinate heme, a slower autoxidation and in general has properties more akin to oxygen transport proteins.	Oxygen	265-271	neuroglobin	Danio rerio	26-29
26721561-6	2016	We observe that zebrafish Ngb and Cygb2 have comparable spectral features to those of human Ngb and Cygb, consistent with a six-coordinate heme, whereas unexpectedly Cygb1 has a five-coordinate heme, a slower autoxidation and in general has properties more akin to oxygen transport proteins.	Oxygen	265-271	cytoglobin 1	Danio rerio	166-171
26853854-4	2016	Addition of hydroperoxy radical precursors to the gas mixture (methanol and oxygen) subsequently led to a competition for photolytically generated Cl atoms and a simultaneous prompt formation of both ClO and HO2 radicals.	Oxygen	76-82	heme oxygenase 2	Homo sapiens	208-211
26815878-2	2016	The crystal structure of the compound Nd(DMP)3 (1, DMP = dimethyl phosphate) revealed a polymeric arrangement in which each Nd(III) center is surrounded by six DMP oxygen atoms in a pseudo-octahedral environment.	Oxygen	164-170	dentin sialophosphoprotein	Homo sapiens	38-46
26760116-0	2016	Low Oxygen Tension Modulates the Insulin-Like Growth Factor-1 or -2 Signaling via Both Insulin-Like Growth Factor-1 Receptor and Insulin Receptor to Maintain Stem Cell Identity in Placental Mesenchymal Stem Cells.	Oxygen	4-10	insulin receptor	Homo sapiens	129-145
26760116-9	2016	This IGF/low oxygen tension-mediated proliferation was receptor dependent because neutralization of the IGF-1R inhibited PMSC proliferation in the presence of IGF-1 and the IR in presence of IGF-2.	Oxygen	13-19	insulin receptor	Homo sapiens	173-175
26760116-11	2016	We conclude that low-oxygen tension can modify the IGF-1 or IGF-2 signaling via the IGF-1R and IR in PMSCs.	Oxygen	21-27	insulin receptor	Homo sapiens	95-97
30294327-14	2018	Also, a time-dependent increase of Siglec-6 by MC was observed under 1% O2.	Oxygen	72-74	sialic acid binding Ig like lectin 6	Homo sapiens	35-43
26546832-5	2016	Hypoxia (6-24h, 1% O2) induced autophagy in CMECs as evidenced by formation of punctate LC3, increased conversion of LC3-I to LC3-II and increased p62 degradation.	Oxygen	19-21	annexin A3	Rattus norvegicus	88-91
26546832-5	2016	Hypoxia (6-24h, 1% O2) induced autophagy in CMECs as evidenced by formation of punctate LC3, increased conversion of LC3-I to LC3-II and increased p62 degradation.	Oxygen	19-21	annexin A3	Rattus norvegicus	117-120
26546832-5	2016	Hypoxia (6-24h, 1% O2) induced autophagy in CMECs as evidenced by formation of punctate LC3, increased conversion of LC3-I to LC3-II and increased p62 degradation.	Oxygen	19-21	annexin A3	Rattus norvegicus	117-120
26546832-5	2016	Hypoxia (6-24h, 1% O2) induced autophagy in CMECs as evidenced by formation of punctate LC3, increased conversion of LC3-I to LC3-II and increased p62 degradation.	Oxygen	19-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	147-150
26863525-2	2016	Syncytiotrophoblast hCG secretion is modulated by the partial pressure of oxygen (pO2), reactive oxygen species (ROS) and potassium (K+) channels.	Oxygen	74-80	chorionic gonadotropin subunit beta 5	Homo sapiens	20-23
30025813-6	2018	MiR-505 downregulation also ameliorated MPP+ -induced cytotoxicity, by preserving MMP and reducing LDH level, caspase-3 and reactive oxygen species activities.	Oxygen	133-139	microRNA 505	Homo sapiens	0-7
26748625-1	2016	OBJECTIVE: This study aimed to determine whether initiation of controlled oxygen therapy at ED presentation increased the proportion of patients with chronic obstructive pulmonary disease (COPD) achieving the COPD-X guideline target SpO2 range (88-92%) at 30 min and if it impacted total hospital length of stay or in-hospital mortality.	Oxygen	74-80	COPD	Homo sapiens	189-193
26748625-1	2016	OBJECTIVE: This study aimed to determine whether initiation of controlled oxygen therapy at ED presentation increased the proportion of patients with chronic obstructive pulmonary disease (COPD) achieving the COPD-X guideline target SpO2 range (88-92%) at 30 min and if it impacted total hospital length of stay or in-hospital mortality.	Oxygen	74-80	COPD	Homo sapiens	209-213
26748625-7	2016	CONCLUSION: Patients with exacerbations of COPD receiving controlled oxygen therapy were more likely to achieve SpO2 within the COPD-X guideline target range without being more likely to be hypoxic.	Oxygen	69-75	COPD	Homo sapiens	43-47
26748625-7	2016	CONCLUSION: Patients with exacerbations of COPD receiving controlled oxygen therapy were more likely to achieve SpO2 within the COPD-X guideline target range without being more likely to be hypoxic.	Oxygen	69-75	COPD	Homo sapiens	128-132
30976318-6	2016	First, the small size of the ligaments and pores in our mesoporous catalyst (~10 nm) results in a high BET surface area (43 m2/g) and therefore a high density of oxygen-evolution catalytic sites per unit mass.	Oxygen	162-168	delta/notch like EGF repeat containing	Homo sapiens	103-106
27476200-2	2016	At the first stage of rhizobial evolution, transformation of free-living diazotrophs (related to Rhodopseudomonas) to symbiotic N2-fixers (Bradyrhizobium) occurred due to the acquisition of the fix gene system, which is responsible for providing nitrogenase with electrons and reducing equivalents, as well as for oxygen-dependent regulation of nitrogenase synthesis in planta, and then of the nod genes responsible for the synthesis of the lipo- chito-oligosaccharide Nod factors, which induce root nodule development.	Oxygen	314-320	atrophin 1	Homo sapiens	394-397
27476200-2	2016	At the first stage of rhizobial evolution, transformation of free-living diazotrophs (related to Rhodopseudomonas) to symbiotic N2-fixers (Bradyrhizobium) occurred due to the acquisition of the fix gene system, which is responsible for providing nitrogenase with electrons and reducing equivalents, as well as for oxygen-dependent regulation of nitrogenase synthesis in planta, and then of the nod genes responsible for the synthesis of the lipo- chito-oligosaccharide Nod factors, which induce root nodule development.	Oxygen	314-320	atrophin 1	Homo sapiens	469-472
30075199-3	2018	In the present study, the potential protective effects of LanCL1 against ischemia was investigated in an in vitro model mimicked by oxygen and glucose deprivation (OGD) in neuronal HT22 cells.	Oxygen	132-138	LanC (bacterial lantibiotic synthetase component C)-like 1	Mus musculus	58-64
26756198-2	2016	In this work, ammonium peroxotellurates (NH4 )4 Te2 (mu-OO)2 (mu-O)O4 (OH)2 (1) and (NH4 )5 Te2 (mu-OO)2 (mu-O)O5 (OH) 1.28 H2 O 0.72 H2 O2 (2) were isolated from 5 % hydrogen peroxide aqueous solutions of ammonium tellurate and characterized by single-crystal and powder X-ray diffraction analysis, by Raman spectroscopy and thermal analysis.	Oxygen	56-58	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	48-51
25765253-1	2016	PURPOSE: To benchmark MOBILE (Mapping of Oxygen By Imaging Lipid relaxation Enhancement), a recent noninvasive MR method of mapping changes in tumor hypoxia, electron paramagnetic resonance (EPR) oximetry, and dynamic contrast-enhanced MRI (DCE-MRI) as biomarkers of changes in tumor hemodynamics induced by the antivascular agent combretastatin A4 (CA4).	Oxygen	41-47	carbonic anhydrase 4	Mus musculus	350-353
30225695-1	2018	Relatively short-term (2.5 or 5 h) exposure of Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) resulted in an increase in LPO level and reduction of antioxidant activity in the blood serum.	Oxygen	62-68	lactoperoxidase	Rattus norvegicus	144-147
27571978-5	2016	Our results demonstrate that formyl peptide receptor 1 (FPR1) and neutrophilic NADPH oxidase (NOX2) are required for the rapid depletion of microenvironmental oxygen and compensatory responses, resulting in a dramatic enrichment of an anaerobic bacterial consortium.	Oxygen	159-165	cytochrome b-245, beta polypeptide	Mus musculus	94-98
26615669-5	2016	Under light illumination, PSII can split water into protons, oxygen, and electrons and can generate a proton gradient for ATPase to produce ATP.	Oxygen	61-67	dynein axonemal heavy chain 8	Homo sapiens	122-128
26885373-5	2016	Monomeric ANXA2 (ANXA2m) was identified as a TLR2-binding protein enriched in 5 % O2 by mass spectrometry.	Oxygen	82-84	toll-like receptor 2	Mus musculus	45-49
26446112-7	2016	Orexin levels in the lateral hypothalamus/perifornical region (LH/P) and hypothalamic pathology were assessed with immunohistochemistry and oxygen polarography.	Oxygen	140-146	hypocretin	Mus musculus	0-6
26735018-7	2016	The activity of these kinases is stimulated in normoxia by the oxygen-sensing prolyl hydroxylase PHD1 (also known as EGLN2).	Oxygen	63-69	egl-9 family hypoxia inducible factor 2	Homo sapiens	97-101
26735018-7	2016	The activity of these kinases is stimulated in normoxia by the oxygen-sensing prolyl hydroxylase PHD1 (also known as EGLN2).	Oxygen	63-69	egl-9 family hypoxia inducible factor 2	Homo sapiens	117-122
26660293-0	2016	TiO2-modified CNx nanowires as a Pt electrocatalyst support with high activity and durability for the oxygen reduction reaction.	Oxygen	102-108	calnexin	Homo sapiens	14-17
28867175-8	2018	There was a significant negative correlation between oxygen saturation, plasma P-selectin (r=-0.865), E-selectin (r=-0.401), and PF4 (r=-0.792) in patients with CCHD.	Oxygen	53-59	platelet factor 4	Homo sapiens	129-132
26660293-1	2016	A Pt/TiO2-modified carbon nitride nanofiber (Pt/TiO2-CNx) catalyst has been synthesized by a chemical method for the oxygen reduction reaction (ORR).	Oxygen	117-123	calnexin	Homo sapiens	53-56
27526168-4	2016	Combined with oxygen probes, such as PtP-C343, we can monitor oxygen dynamics at the submicron level by this real-time microscopy.	Oxygen	62-68	protein tyrosine phosphatase receptor type U	Homo sapiens	37-40
26611638-7	2016	Additionally, Li-doped single-layer SnS2 is active for overall water splitting under visible light radiation whereas Mg and Al-doped SnS2 are only suitable for oxygen evolution.	Oxygen	160-166	sodium voltage-gated channel alpha subunit 11	Homo sapiens	133-137
29396649-7	2018	By using CPT1A floxed mice, we have observed that genetic ablation of CPT1A recapitulates the effect of ghrelin on GABA release in cortical neurons, inducing reductions in mitochondrial oxygen consumption, cell content of citrate and alpha-ketoglutarate, and GABA shunt enzyme activity.	Oxygen	186-192	ghrelin	Mus musculus	104-111
26970791-7	2016	The best MPP-modified PUF showed oxygen index 24.6.	Oxygen	33-39	M-phase phosphoprotein 6	Homo sapiens	9-12
26361242-6	2016	Multivariable Cox regression demonstrated that slope of oxygen saturation during the first 10 minutes after extubation was associated with graft failure (below median: hazard ratio 1.30, 95% CI 1.03-1.64), with 5-year graft survival of 70.0% (95%CI 64.5%-74.8%) for donors above the median versus 61.4% (95%CI 55.5%-66.7%) for those below the median.	Oxygen	56-62	cytochrome c oxidase subunit 8A	Homo sapiens	14-17
29680477-6	2018	A YAP1 mutant construct, YAP1S127A, which stimulates binding of YAP1 to TEAD1, upregulates the expression of PGC1alpha, induces mitochondrial biogenesis, and increases oxygen consumption and glycolytic flux in ECs; in contrast, YAP1S94A, which fails to bind to TEAD1, attenuates these effects.	Oxygen	168-174	yes-associated protein 1	Mus musculus	2-6
26488220-16	2016	Blockade of hippocampal brain-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human TrkB-Fc chimera significantly blunted the protection by the hyperbaric oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurotrophic factor mimicked the action of hyperbaric oxygen and preserved hippocampal neurogenesis after acute carbon monoxide poisoning.	Oxygen	198-204	neurotrophic receptor tyrosine kinase 2	Homo sapiens	127-131
26488220-16	2016	Blockade of hippocampal brain-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human TrkB-Fc chimera significantly blunted the protection by the hyperbaric oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurotrophic factor mimicked the action of hyperbaric oxygen and preserved hippocampal neurogenesis after acute carbon monoxide poisoning.	Oxygen	346-352	neurotrophic receptor tyrosine kinase 2	Homo sapiens	127-131
26644182-2	2016	PHD1 is also able to regulate mitotic progression through the regulation of the crucial centrosomal protein Cep192, establishing a link between the oxygen-sensing and the cell cycle machinery.	Oxygen	148-154	egl-9 family hypoxia inducible factor 2	Homo sapiens	0-4
29680477-6	2018	A YAP1 mutant construct, YAP1S127A, which stimulates binding of YAP1 to TEAD1, upregulates the expression of PGC1alpha, induces mitochondrial biogenesis, and increases oxygen consumption and glycolytic flux in ECs; in contrast, YAP1S94A, which fails to bind to TEAD1, attenuates these effects.	Oxygen	168-174	yes-associated protein 1	Mus musculus	25-29
30032070-6	2018	Oxygen evolution capacity decreased slightly in the plants lacking Lhcb4 (koLHCB4) and Lhcb6 (koLHCB6).	Oxygen	0-6	light harvesting complex photosystem II subunit 6	Arabidopsis thaliana	87-92
27581016-1	2016	Oxygen-dependent hydroxylation of critical proline residues, catalyzed by prolyl hydroxylase (PHD1-3) enzymes, is a crucial posttranslational modification (PTM) within the canonical hypoxia-inducible factor (HIF)-centric cellular oxygen-sensing pathway.	Oxygen	0-6	egl-9 family hypoxia inducible factor 2	Homo sapiens	94-100
27581016-1	2016	Oxygen-dependent hydroxylation of critical proline residues, catalyzed by prolyl hydroxylase (PHD1-3) enzymes, is a crucial posttranslational modification (PTM) within the canonical hypoxia-inducible factor (HIF)-centric cellular oxygen-sensing pathway.	Oxygen	230-236	egl-9 family hypoxia inducible factor 2	Homo sapiens	94-100
27812977-4	2016	Balancing the oxygen regulatory environment with the demands for energy and need to maintain metabolism during this process places AMPK at the center of maintaining placental cellular homeostasis as it integrates and responds to numerous complex stimuli.	Oxygen	14-20	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	131-135
27982694-8	2016	Cldn6 transcriptional regulation was also assessed in hypoxic conditions due to low oxygen tension observed during smoking.	Oxygen	84-90	claudin 6	Mus musculus	0-5
30040383-3	2018	The introduction of oxygen vacancies to cobalt oxide not only promotes its reversible Co-O   Co-O-OH redox reaction but also leads to good oxygen reduction reaction and oxygen evolution (ORR/OER) performance (a half-wave potential of 0.84 V, four-electron transfer process for ORR, and 330 mV overpotential, 58 mV dec-1 Tafel slope for OER).	Oxygen	20-26	deleted in esophageal cancer 1	Homo sapiens	314-319
27630759-1	2016	Mitochondrial superoxide dismutase 2 (SOD2) converts superoxide anions to hydrogen peroxide and oxygen.	Oxygen	96-102	superoxide dismutase 2	Homo sapiens	38-42
28191417-3	2016	To create 2DEG at LAO/STO interface, regardless of growing temperature from 25 to 700  C, we found that environment with oxygen deficient during the deposition of LAO overlayer is essentially required.	Oxygen	121-127	interleukin 4 induced 1	Homo sapiens	18-21
28191417-3	2016	To create 2DEG at LAO/STO interface, regardless of growing temperature from 25 to 700  C, we found that environment with oxygen deficient during the deposition of LAO overlayer is essentially required.	Oxygen	121-127	interleukin 4 induced 1	Homo sapiens	163-166
26149285-3	2016	In this review, we first discuss how redox-sensitive TRP channels such as TRPA1 have recently emerged as sensors of the relatively inert oxidant O2.	Oxygen	145-147	transient receptor potential cation channel subfamily A member 1	Homo sapiens	74-79
26149285-4	2016	With regard to the physiological significance of O2 sensor TRP channels, vagal TRPA1 channels are mainly discussed with respect to their role in respiratory regulation in comparison with canonical pathways in glomus cells of the carotid body, which is a well-established O2-sensing organ.	Oxygen	271-273	transient receptor potential cation channel subfamily A member 1	Homo sapiens	79-84
26325148-10	2016	The increased PGHS-1-dependent oxygen consumption and the total activity of PGHS-1 in diabetic animals remained very significant (p &lt; 0.001) also upon adjusting for blood platelet PGHS-1 abundance.	Oxygen	31-37	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	14-20
26972599-3	2016	We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities.	Oxygen	29-35	cytoglobin	Mus musculus	49-53
26972599-3	2016	We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities.	Oxygen	29-35	cytoglobin	Mus musculus	57-61
26972599-3	2016	We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities.	Oxygen	37-39	cytoglobin	Mus musculus	49-53
26972599-3	2016	We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities.	Oxygen	37-39	cytoglobin	Mus musculus	57-61
26972599-4	2016	Studies involving CYGB-gene-deleted mice have led us to suppose that CYGB functions as a regulator of O2 homeostasis; when O2 homeostasis is disrupted, HSCs are activated and play a key role(s) in hepatic fibrogenesis.	Oxygen	102-104	cytoglobin	Mus musculus	69-73
27843647-10	2016	Positive correlation was found between Cyst C levels and respiratory disturbance index (RDI) (r = 0.240, p = 0.039) and percentage of time with oxygen saturation &lt;90% (r = 0.290, p = 0.02) and negative correlation was found between Cyst C levels and average oxygen saturation during sleep (r = -0.291, p = 0.012).	Oxygen	261-267	cystatin C	Homo sapiens	39-45
28969979-1	2018	BACKGROUND: B-type natriuretic peptide (BNP) has been found to be inversely related to peak oxygen consumption (peak VO2) in various patient populations.	Oxygen	92-98	natriuretic peptide B	Homo sapiens	12-38
27825150-5	2016	Multiple linear regression was performed to assess the association between the half-time of recovery of oxygen consumption (T1/2 VO2) and exercise capacity (6-minute walking distance, 6MWD).	Oxygen	104-110	interleukin 1 receptor like 1	Homo sapiens	124-132
26708865-8	2016	The putative role of CPT1C in the regulation of complex-lipid metabolism is supported by the observation that it is highly expressed in certain virulent tumor cells, conferring them resistance to glucose- and oxygen-deprivation.	Oxygen	209-215	carnitine palmitoyltransferase 1C	Homo sapiens	21-26
28969979-1	2018	BACKGROUND: B-type natriuretic peptide (BNP) has been found to be inversely related to peak oxygen consumption (peak VO2) in various patient populations.	Oxygen	92-98	natriuretic peptide B	Homo sapiens	40-43
26608471-6	2015	As a part of this work, the O2 broadening coefficient for the absorption line of HO2 radicals at 6638.21 cm(-1) has been determined (gammaO2 = 0.0289 cm(-1) atm(-1)).	Oxygen	28-30	heme oxygenase 2	Homo sapiens	81-84
29715464-12	2018	In cultured adipocytes, SAT1 overexpression or pharmacological activation with N1, N11-diethylnorspermine (DENSpm) elevated oxygen consumption and increased the expression of beige adipocyte marker UCP1 and PGC-1alpha.	Oxygen	124-130	spermidine/spermine N1-acetyl transferase 1	Mus musculus	24-28
26555823-0	2015	Red-Light-Induced Decomposition of an Organic Peroxy Radical: A New Source of the HO2 Radical.	Oxygen	46-60	heme oxygenase 2	Homo sapiens	82-85
27508381-8	2016	Moreover, the biodegradability of wastewaters, measured as biological and chemical oxygen demand (BOD5/COD), increased from 0.22 to 0.53.	Oxygen	83-89	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	103-106
30009306-0	2018	Role of transition metals in a charge transfer mechanism and oxygen removal in Li1.17Ni0.17Mn0.5Co0.17O2: experimental and first-principles analysis.	Oxygen	61-67	transglutaminase 1	Homo sapiens	79-82
26310985-6	2015	RESULTS: Immature SP-B, but not the mature form, was significantly higher in HF patients than in controls and was independently related to DLco, peak oxygen uptake and ventilatory efficiency.	Oxygen	150-156	surfactant protein B	Homo sapiens	18-22
26490118-7	2015	We show that growth under anaerobic conditions in the absence of molecular oxygen abrogates Sup35 protein damage and suppresses the high frequency of [PSI(+)] formation in an autophagy mutant.	Oxygen	75-81	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	92-97
30009306-1	2018	Oxygen removal from high capacity Li-rich layered oxide Li1.17Ni0.17Mn0.5Co0.17O2 affects the charge transfer process during cycling.	Oxygen	0-6	transglutaminase 1	Homo sapiens	56-59
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	major vault protein	Homo sapiens	157-180
30009306-8	2018	A detailed explanation of oxygen removal and the charge transfer mechanism of Li1.17Ni0.17Mn0.5Co0.17O2 and Li2MnO3 is provided in the current experimental and density functional theory based study.	Oxygen	26-32	transglutaminase 1	Homo sapiens	78-81
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	major vault protein	Homo sapiens	182-185
26492917-1	2015	The EglN2/PHD1 prolyl hydroxylase is an important oxygen sensor contributing to breast tumorigenesis.	Oxygen	50-56	egl-9 family hypoxia inducible factor 2	Homo sapiens	4-9
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	44-46	major vault protein	Homo sapiens	295-298
26492917-1	2015	The EglN2/PHD1 prolyl hydroxylase is an important oxygen sensor contributing to breast tumorigenesis.	Oxygen	50-56	egl-9 family hypoxia inducible factor 2	Homo sapiens	10-14
30022066-2	2018	AOX is a non-proton pumping, mitochondrial inner membrane-bound, single-subunit enzyme that can bypass electron transport through the cytochrome segment, providing an additional site for ubiquinone reoxidation and oxygen reduction upon respiratory chain overload.	Oxygen	214-220	Aldox89A	Drosophila melanogaster	0-3
26611738-7	2015	Overexpression of b5R induced higher mitochondrial functions such as ATP production rate, oxygen consumption rate, and activities of complexes I and II, without formation of further reactive oxygen species, consistent with lower levels of oxidative/nitrative damage and resistance to apoptotic cell death.	Oxygen	90-96	cytochrome b5 reductase 3	Homo sapiens	18-21
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	157-180
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	182-185
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	295-298
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	157-180
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	182-185
26692822-9	2015	Hypoxia also concentration-dependently (5 % O2, 3 % O2, 1 % O2) reduced mRNA expression level of P-glycoprotein (P-gp), multidrug resistance protein (MRP1), lung resistance protein (LRP), and decreased the protein expression level of hypoxia-inducible factor-1alpha (HIF-1alpha), P-gp MRP1, and LRP.	Oxygen	52-54	major vault protein	Homo sapiens	295-298
26151122-8	2015	Taken together, these data introduce PTH as a regulator of oxygen-independent HIF-1alpha levels through a mechanism involving cyclic AMP, Hsp90, and the cytoskeleton.	Oxygen	59-65	parathyroid hormone	Mus musculus	37-40
26460165-6	2015	A dirigent protein from Gossypium hirsutum (GhDIR4) was found to confer atropselectivity to the coupling of hemigossypol in presence of laccase and O2 as an oxidizing agent.	Oxygen	148-150	dirigent protein 4	Gossypium hirsutum	44-50
29719107-0	2018	MOF-Derived Hollow CoS Decorated with CeOx Nanoparticles for Boosting Oxygen Evolution Reaction Electrocatalysis.	Oxygen	70-76	lysine acetyltransferase 8	Homo sapiens	0-3
26769839-5	2015	Exposure to &gt; 96% oxygen for 60 minutes significantly changed the expression of 20 different genes, including upregulation of two different humanins - MTRNR2L2 and MTRNR2L8, and activated a "cell survival" network as detected by Ingenuity Pathway Analyses.	Oxygen	21-27	MT-RNR2 like 2 (pseudogene)	Homo sapiens	154-162
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	72-74	superoxide dismutase 2	Homo sapiens	0-4
29784877-1	2018	3-Hydroxyanthranilate 3,4-dioxygenase (HAO) is an iron-dependent protein that activates O2 and inserts both oxygen atoms into 3-hydroxyanthranilate (3-HAA).	Oxygen	88-90	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	0-37
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	72-74	superoxide dismutase 2	Homo sapiens	156-160
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	113-119	superoxide dismutase 2	Homo sapiens	0-4
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	113-119	superoxide dismutase 2	Homo sapiens	156-160
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	105-107	superoxide dismutase 2	Homo sapiens	0-4
26359457-5	2015	Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC.	Oxygen	105-107	superoxide dismutase 2	Homo sapiens	156-160
26359457-9	2015	First, Sod2 maintains highly functional mitochondria, by scavenging O2 ( -), to support the high metabolic activity of OCCC.	Oxygen	68-70	superoxide dismutase 2	Homo sapiens	7-11
29905753-0	2018	Porous Co3O4/SnO2 quantum dot (QD) heterostructures with abundant oxygen vacancies and Co2+ ions for highly efficient gas sensing and oxygen evolution reaction.	Oxygen	66-72	strawberry notch homolog 1	Homo sapiens	13-16
26542636-4	2015	We showed in vitro that ABC strongly and synergistically protected neuronal cells from oxidative stress in the oxygen and glucose deprivation model, as well as dopaminergic neurons from cell death in the 6-hydroxydopamine (6-OHDA) rat model.	Oxygen	111-117	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	24-27
29905753-0	2018	Porous Co3O4/SnO2 quantum dot (QD) heterostructures with abundant oxygen vacancies and Co2+ ions for highly efficient gas sensing and oxygen evolution reaction.	Oxygen	134-140	strawberry notch homolog 1	Homo sapiens	13-16
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Oxygen	237-243	deleted in esophageal cancer 1	Homo sapiens	225-230
26296657-0	2015	pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation.	Oxygen	82-88	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
26296657-0	2015	pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation.	Oxygen	82-88	ceramide kinase like	Homo sapiens	42-47
26296657-10	2015	Additionally, our work showed that the oxygen sensors PHD1 and PHD3 are involved in CERKL degradation.	Oxygen	39-45	egl-9 family hypoxia inducible factor 2	Homo sapiens	54-58
26296657-10	2015	Additionally, our work showed that the oxygen sensors PHD1 and PHD3 are involved in CERKL degradation.	Oxygen	39-45	ceramide kinase like	Homo sapiens	84-89
26296657-11	2015	Collectively, our results indicated that pVHL interacts with CERKL and ubiquitinates it for oxygen dependent proteasomal degradation.	Oxygen	92-98	von Hippel-Lindau tumor suppressor	Homo sapiens	41-45
26296657-11	2015	Collectively, our results indicated that pVHL interacts with CERKL and ubiquitinates it for oxygen dependent proteasomal degradation.	Oxygen	92-98	ceramide kinase like	Homo sapiens	61-66
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Oxygen	237-243	deleted in esophageal cancer 1	Homo sapiens	318-323
30090268-3	2015	The rate-determining step in the catalytic cycle is hydrogen atom transfer from H3Trip to O2 in the H3Trip/O2 complex to produce the radical pair (H3Trip + HO2 ) as an intermediate, which was detected as a triplet EPR signal with fine-structure by the EPR measurements at low temperature.	Oxygen	90-92	heme oxygenase 2	Homo sapiens	156-159
26126188-5	2015	The n-pi electron donor-acceptor (n-pi EDA) interaction between diaromatic ring of naproxen (pi-electron acceptors) and the siloxane oxygens (n-donors) of kaolinite is the dominant sorption mechanism.	Oxygen	133-140	ectodysplasin A	Homo sapiens	39-42
29763606-5	2018	Through inhibition of HK2, miR-216a-5p dampens glycolysis by reducing HK activity, glucose uptake, lactate production, ATP generation, extracellular acidification rate (ECAR), and increasing oxygen consumption rate (OCR) in uveal melanoma cells.	Oxygen	191-197	hexokinase 2	Homo sapiens	22-25
29804242-8	2018	The Cdc42 inhibitor CASIN increased adipogenic and osteogenic differentiation potential in ADMSCs from 24-month old rats, and decreased the levels of radical oxygen species (ROS), p16INK4a levels, F-actin, and the activity of the ERK1/2 and JNK signaling pathways that were all elevated in these cells.	Oxygen	158-164	cell division cycle 42	Rattus norvegicus	4-9
26077317-10	2015	The key subsequent processes are the reactions Cl2(-) + O3   ClO + O2 + Cl(-) and ClO + H2O2   HOCl + HO2.	Oxygen	67-69	heme oxygenase 2	Homo sapiens	102-105
29119535-7	2018	Significant differences of oxygen consumption and ROS production were related to higher mitochondrial complex II activity (succinate dehydrogenase-SDH) in CSy rather than to mitochondrial number.	Oxygen	27-33	serine dehydratase	Homo sapiens	147-150
26203919-5	2015	The short-term exposure of SCAP to glucose/oxygen deprivation (GOD) in the presence, but mainly in deprivation, of serum (SGOD) elicited a proangiogenesis effect indicated by expression of angiogenesis-related genes involved in vascular endothelial growth factor (VEGF)/VEGFR and angiopoietins/Tie pathways.	Oxygen	43-49	SREBF chaperone	Homo sapiens	27-31
29874573-6	2018	In addition, we show that the specific inhibition of SDHA degradation by UPS promotes SDHA-dependent oxygen consumption and increases ATP, malate, and citrate levels.	Oxygen	101-107	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	53-57
26742253-0	2015	Research Report: Intermittent hypobaric hypoxia and hyperbaric oxygen on GAP-43 in the rat carotid body.	Oxygen	63-69	growth associated protein 43	Rattus norvegicus	73-79
29874573-6	2018	In addition, we show that the specific inhibition of SDHA degradation by UPS promotes SDHA-dependent oxygen consumption and increases ATP, malate, and citrate levels.	Oxygen	101-107	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	86-90
26742253-1	2015	Adaptive changes in the carotid body (CB) including the expression of the growth-associated protein-43 (GAP-43) have been studied in response to low, but not high, oxygen exposure.	Oxygen	164-170	growth associated protein 43	Rattus norvegicus	104-110
29874879-9	2018	The mitochondrial respiration functions (such as oxygen consumption rate, ATP production, and maximal respiratory capacity) were decreased in NPC2 knockdown, and free cholesterol accumulated in the HSCs, while NPC2-overexpressed cells remained normal.	Oxygen	49-55	NPC intracellular cholesterol transporter 2	Homo sapiens	142-146
26742253-2	2015	Expression of GAP-43 in the CB of rats under different atmospheric pressures and oxygen partial pressure (PO2) conditions was investigated.	Oxygen	81-87	growth associated protein 43	Rattus norvegicus	14-20
29365138-4	2018	NEF from Nox4-expressing HEK293 cells exhibited oxygen and H2O2 concentration-dependent NADPH oxidation rate.	Oxygen	48-54	NADPH oxidase 4	Homo sapiens	9-13
26399300-4	2015	The Tafel slope corresponding to oxygen reduction for Co(OH)2-MoS2/rGO is estimated to be 63 mV dec(-1) compared to 68 mV dec(-1) displayed by the state-of-the-art Pt/C catalyst.	Oxygen	33-39	deleted in esophageal cancer 1	Homo sapiens	96-102
26399300-4	2015	The Tafel slope corresponding to oxygen reduction for Co(OH)2-MoS2/rGO is estimated to be 63 mV dec(-1) compared to 68 mV dec(-1) displayed by the state-of-the-art Pt/C catalyst.	Oxygen	33-39	deleted in esophageal cancer 1	Homo sapiens	122-128
29843785-7	2018	In vivo markers of angiogenesis (vascular endothelial growth factor, angiopoietin 2 [Ang2], tyrosine kinase receptor [Tie2]) were significantly associated with oxidative damage and oxygen metabolism in the inflamed synovium.	Oxygen	181-187	angiopoietin 2	Homo sapiens	69-83
26227854-5	2015	We found that the JAK2(V617F)-mutant cells were associated with increased oxygen consumption rate and extracellular acidification rate than the JAK2(WT) cells and there was an increased glutamine metabolism in JAK2(V617F)-mutant cells compared to wild-type cells.	Oxygen	74-80	Janus kinase 2	Homo sapiens	18-22
29843785-7	2018	In vivo markers of angiogenesis (vascular endothelial growth factor, angiopoietin 2 [Ang2], tyrosine kinase receptor [Tie2]) were significantly associated with oxidative damage and oxygen metabolism in the inflamed synovium.	Oxygen	181-187	TEK receptor tyrosine kinase	Homo sapiens	118-122
25833395-0	2015	bFGF Protects Pre-oligodendrocytes from Oxygen/Glucose Deprivation Injury to Ameliorate Demyelination.	Oxygen	40-46	fibroblast growth factor 2	Rattus norvegicus	0-4
29808533-0	2018	Suppressing Surface Lattice Oxygen Release of Li-Rich Cathode Materials via Heterostructured Spinel Li4 Mn5 O12 Coating.	Oxygen	28-34	lipase family member N	Homo sapiens	100-103
29808533-3	2018	Herein, it is identified that this predicament can be diminished by constructing a spinel Li4 Mn5 O12 coating, which is inherently stable in the lattice framework to prevent oxygen release of the lithium-rich layered oxides at the deep delithiated state.	Oxygen	174-180	lipase family member N	Homo sapiens	90-93
25619842-0	2015	SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.	Oxygen	82-88	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-5
29808533-7	2018	These results highlight the essentiality of oxygen framework stability and effectiveness of this spinel Li4 Mn5 O12 coating strategy in stabilizing the surface of lithium-rich layered oxides against lattice oxygen escaping for designing high-performance cathode materials for high-energy-density lithium-ion batteries.	Oxygen	207-213	lipase family member N	Homo sapiens	104-107
29430871-2	2018	The Ru(C-bpy)2 /mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C-bpy)2 alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm.	Oxygen	145-151	lactate dehydrogenase A	Mus musculus	16-20
26269525-2	2015	mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.	Oxygen	206-212	CREB regulated transcription coactivator 1	Mus musculus	80-86
26269525-2	2015	mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.	Oxygen	206-212	CREB regulated transcription coactivator 2	Mus musculus	91-97
26242736-5	2015	The mouse model of oxygen-induced retinopathy, which recapitulates ischemia-induced aberrant neovessel growth, is characterized by increased expression of miR-155 and localized areas of microglia activation.	Oxygen	19-25	microRNA 155	Mus musculus	155-162
28194019-9	2018	Furthermore, IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.	Oxygen	71-77	interleukin 25	Mus musculus	13-18
26504644-0	2015	Cerebral metabolic rate of oxygen (CMRO2) assessed by combined Doppler and spectroscopic OCT.	Oxygen	27-33	plexin A2	Mus musculus	89-92
26554847-0	2015	Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions.	Oxygen	105-111	ATP binding cassette subfamily B member 5	Homo sapiens	75-80
29477977-0	2018	Formation of Cys-heme cross-link in K42C myoglobin under reductive conditions with molecular oxygen.	Oxygen	93-99	myoglobin	Physeter catodon	41-50
26349058-6	2015	The mRNA expression of EPOR was doubled in 5% compared with 21% oxygen, and this was associated with increased EPOR assessed by immunofluorescence and Western blot.	Oxygen	64-70	erythropoietin receptor	Bos taurus	23-27
25500545-5	2015	We found that RSUME is expressed in human VHL tumors (renal clear-cell carcinoma (RCC), pheochromocytoma and hemangioblastoma) and by overexpressing or silencing RSUME in a pVHL-HIF-oxygen-dependent degradation stability reporter assay, we determined that RSUME is necessary for the loss of function of type 2 pVHL mutants.	Oxygen	182-188	von Hippel-Lindau tumor suppressor	Homo sapiens	173-177
29407525-2	2018	In this paper, we aim to study the influence of microcirculation alterations in DM2 patients on fluid and oxygen exchanges through a model analysis.	Oxygen	106-112	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	80-83
26292995-6	2015	However, after AA treatment, aox1a plants showed a significant reduction in both respiratory O2 uptake and NaHCO3-dependent O2 evolution.	Oxygen	93-95	alternative oxidase 1A	Arabidopsis thaliana	29-34
26292995-6	2015	However, after AA treatment, aox1a plants showed a significant reduction in both respiratory O2 uptake and NaHCO3-dependent O2 evolution.	Oxygen	124-126	alternative oxidase 1A	Arabidopsis thaliana	29-34
26611735-2	2015	The stability of HIF-1alpha protein is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	129-154
26611735-2	2015	The stability of HIF-1alpha protein is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	156-159
29407525-9	2018	In addition, when the oxygen releasing capacity of hemoglobin was confined by glycosylated hemoglobin (HbA1) in the case of diabetes, the plasma could not be complemented with adequate oxygen and thus the hypoxic tissue range will be extended.	Oxygen	22-28	hemoglobin subunit alpha 1	Homo sapiens	103-107
29407525-10	2018	This study illustrates that when microcirculation disturbances, including the structure of capillary network, the wall osmosis property and the capacity of blood binding oxygen occur in DM2, some negative impacts are raised on microvascular hemodynamics and metabolism circumstance of interstitial tissue.	Oxygen	170-176	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	186-189
26509703-6	2015	In spite of these similarities, they catalyze very different reactions: Nap abstracts an oxygen atom from nitrate releasing nitrite, whereas FdH catalyzes a hydrogen atom transfer from formate and releases carbon dioxide.	Oxygen	89-95	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	141-144
26190566-3	2015	The nuclear-coded subunits are essentially involved in the regulation of oxygen consumption and proton translocation by COX, since their removal or modification changes the activity and their mutation causes mitochondrial diseases.	Oxygen	73-79	cytochrome c oxidase subunit 8A	Homo sapiens	120-123
29540477-6	2018	We show that nuclear CHCHD10 protein down-regulates the expression of genes harboring the oxygen-responsive element (ORE) in their promoters by interacting with and augmenting the activity of the largely uncharacterized transcriptional repressor CXXC finger protein 5 (CXXC5).	Oxygen	90-96	CXXC finger protein 5	Homo sapiens	246-267
26211925-3	2015	We found that cell aggregates derived from late stage Flk-1(+) cells had a relatively small size and a low oxygen consumption rate (OCR) compared with those derived from Flk-1(-) cells.	Oxygen	107-113	kinase insert domain protein receptor	Mus musculus	54-59
26885114-0	2015	Delta-aminolevulinate synthase 2 polymorphism is associated with maximal oxygen uptake after Living-high exercise-high training-low in a male Chinese population.	Oxygen	73-79	5'-aminolevulinate synthase 2	Homo sapiens	0-32
29540477-6	2018	We show that nuclear CHCHD10 protein down-regulates the expression of genes harboring the oxygen-responsive element (ORE) in their promoters by interacting with and augmenting the activity of the largely uncharacterized transcriptional repressor CXXC finger protein 5 (CXXC5).	Oxygen	90-96	CXXC finger protein 5	Homo sapiens	269-274
26409345-4	2015	It is found that the oxidation of CO on the Td-S isomer occurs through a smaller reaction barrier (0.38 eV) as compared with that on the Td-E isomer (0.70 eV), although the activation of O2 on the latter is much higher than that on the former.	Oxygen	187-189	serine incorporator 3	Homo sapiens	137-141
29406617-6	2018	Electrochemical properties were investigated and, upon electrolysis at 1.30 V versus a normal hydrogen electrode (NHE), both dioxygen production and oxygenation of the indane moiety were observed.	Oxygen	125-133	solute carrier family 9 member C1	Homo sapiens	114-117
26409345-7	2015	Although stronger CO adsorption on the Td-E isomer leads to a higher O2 activation; however, high value of CO adsorption energy deteriorates the catalytic activity of the Td-E isomer towards the CO oxidation reaction.	Oxygen	69-71	serine incorporator 3	Homo sapiens	39-43
26409345-7	2015	Although stronger CO adsorption on the Td-E isomer leads to a higher O2 activation; however, high value of CO adsorption energy deteriorates the catalytic activity of the Td-E isomer towards the CO oxidation reaction.	Oxygen	69-71	serine incorporator 3	Homo sapiens	171-175
29675405-3	2018	The Li1.2Mn0.54-xNbxCo0.13Ni0.13O2-6xF6x shows suppressed voltage fade and higher capacity retention of 98.1% after 200 cycles at rate of 1 C. The replacement of O2- by the strongly electronegative F- is beneficial for suppressed the structure change of Li2MnO3 from the eliminating of oxygen in initial charge process.	Oxygen	32-34	transglutaminase 1	Homo sapiens	4-7
26411341-5	2015	In INS-1 cells, citrate synthase rates correlated with both insulin secretion and oxygen consumption.	Oxygen	82-88	citrate synthase	Rattus norvegicus	16-32
29675405-3	2018	The Li1.2Mn0.54-xNbxCo0.13Ni0.13O2-6xF6x shows suppressed voltage fade and higher capacity retention of 98.1% after 200 cycles at rate of 1 C. The replacement of O2- by the strongly electronegative F- is beneficial for suppressed the structure change of Li2MnO3 from the eliminating of oxygen in initial charge process.	Oxygen	286-292	transglutaminase 1	Homo sapiens	4-7
26196717-8	2015	The ROS generation has been explained on the basis of interaction between photoexcited electrons from conduction band with molecular oxygen adhered to the surface of nanorods owing to favourable redox potentials of O2/O2(-) (-0.20 eV) in normal hydrogen electrode (NHE) scale.	Oxygen	133-139	solute carrier family 9 member C1	Homo sapiens	265-268
26196717-8	2015	The ROS generation has been explained on the basis of interaction between photoexcited electrons from conduction band with molecular oxygen adhered to the surface of nanorods owing to favourable redox potentials of O2/O2(-) (-0.20 eV) in normal hydrogen electrode (NHE) scale.	Oxygen	215-217	solute carrier family 9 member C1	Homo sapiens	265-268
26196717-8	2015	The ROS generation has been explained on the basis of interaction between photoexcited electrons from conduction band with molecular oxygen adhered to the surface of nanorods owing to favourable redox potentials of O2/O2(-) (-0.20 eV) in normal hydrogen electrode (NHE) scale.	Oxygen	218-220	solute carrier family 9 member C1	Homo sapiens	265-268
26289523-8	2015	ROC analyses were performed and significant relationship was found between the EAP diameter with haemoglobin (Hmg), haemotocrit (Hct), and central venous oxygen saturation (ScvO2) and also significant correlation was detected between the IAP diameter and white blood cell (WBC).	Oxygen	154-160	glutamyl aminopeptidase	Homo sapiens	79-82
29527811-5	2018	In addition, the Fe2 O3 @Ni3 Se4 nanotubes with INi:Fe = 1:10 (the atomic ratio between Ni and Fe) show superior electrocatalytic performance toward the oxygen evolution reaction with an overpotential of only 246 mV at 10 mA cm-2 and a low Tafel slope of 51 mV dec-1 in 1 m KOH solution.	Oxygen	153-159	deleted in esophageal cancer 1	Homo sapiens	261-266
26408339-7	2015	In accordance with the association of rapid response transcripts with H2 O2 and ABA signaling, a mutant impaired in ABA sensing (abi-1) was found to be more tolerant to light stress, and the response of several of the rapid response transcripts was altered in mutants impaired in reactive oxygen metabolism.	Oxygen	289-295	Protein phosphatase 2C family protein	Arabidopsis thaliana	129-134
26510508-2	2015	Here we apply complementary electron microscopy and spectroscopy techniques at multi-length scale on well-formed Li1.2(Ni0.13Mn0.54Co0.13)O2 crystals with two different morphologies as well as two commercially available materials with similar compositions, and unambiguously describe the structural make-up of these samples.	Oxygen	138-140	transglutaminase 1	Homo sapiens	113-116
29378832-3	2018	CDP138-/- mice have lower energy expenditure, oxygen consumption, and body temperature than wild-type (WT) mice.	Oxygen	46-52	C2 calcium-dependent domain containing 5	Mus musculus	0-6
26461813-5	2015	SUSD2(+) eMSC were cultured in SFM with bFGF/EGF in 5% O2/5% CO2.	Oxygen	55-57	sushi domain containing 2	Homo sapiens	0-5
29581565-8	2018	Here, we show that ImpL3 coding for Lactate Dehydrogenase in Drosophila, is regulated by ARE-mediated decay (AMD) with dTIS11 contributing to ImpL3 rapid down-regulation upon return to normal oxygen levels after hypoxia.	Oxygen	192-198	Tis11 zinc finger protein	Drosophila melanogaster	119-125
26455726-0	2015	A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction.	Oxygen	71-77	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	24-44
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Oxygen	294-300	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	68-88
29499069-5	2018	PIC1 showed dose-dependent antioxidant activity in a total antioxidant (TAC) assay, hydroxyl radical antioxidant capacity (HORAC) assay, oxygen radical antioxidant capacity (ORAC) assay as well as the thiobarbituric acid reactive substances (TBARS) assay to screen for PIC1 antioxidant activity in human plasma.	Oxygen	137-143	small ubiquitin like modifier 1	Homo sapiens	0-4
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Oxygen	294-300	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	90-93
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Oxygen	323-329	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	68-88
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Oxygen	323-329	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	90-93
26455726-5	2015	An electron transfer shunt from the electrode circumvents the slow dissociation of a ferric hydroxide species, which slows down native CcO (bovine 500 s(-1)), allowing electrocatalytic oxygen reduction rates of 5,000 s(-1) for these biosynthetic models.	Oxygen	185-191	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	135-138
29118013-7	2018	Diminishing glycolytic flux by knockdown of the first and final enzyme of glycolysis, i.e., hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption.	Oxygen	198-204	hexokinase 2	Homo sapiens	92-104
26207545-0	2015	Improvement of Fat Transplantation: Fat Graft With Adipose-Derived Stem Cells and Oxygen-Generating Microspheres.	Oxygen	82-88	FAT atypical cadherin 1	Rattus norvegicus	15-18
26207545-11	2015	CONCLUSIONS: In this study, fat transplantation was improved with oxygen-generating microspheres and ASCs.	Oxygen	66-72	FAT atypical cadherin 1	Rattus norvegicus	28-31
29118013-7	2018	Diminishing glycolytic flux by knockdown of the first and final enzyme of glycolysis, i.e., hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption.	Oxygen	198-204	hexokinase 2	Homo sapiens	106-109
29253589-9	2018	Knockdown of TAMM41 resulted in decreased mitochondrial CDS activity, decreased cardiolipin levels and a decrease in oxygen consumption.	Oxygen	117-123	TAM41 mitochondrial translocator assembly and maintenance homolog	Rattus norvegicus	13-19
26231655-5	2015	Groundwater within and below the PRB was depleted in oxygen compared to groundwater at sites upgradient and at adjacent reference sites.	Oxygen	53-59	RB transcriptional corepressor 1	Homo sapiens	33-36
29259012-1	2018	The prolyl hydroxylase domain-containing proteins (PHD1-3) and the asparaginyl hydroxlyase factor inhibiting HIF (FIH) are oxygen sensors for hypoxia-inducible factor-driven transcription of hypoxia-induced genes, but whether these sensors affect oxygen-dependent epigenetic regulation more broadly is not known.	Oxygen	123-129	egl-9 family hypoxia inducible factor 2	Homo sapiens	51-57
26306982-0	2015	Novel 11beta-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.	Oxygen	95-101	RNA, U1 small nuclear 1	Homo sapiens	0-17
29259012-1	2018	The prolyl hydroxylase domain-containing proteins (PHD1-3) and the asparaginyl hydroxlyase factor inhibiting HIF (FIH) are oxygen sensors for hypoxia-inducible factor-driven transcription of hypoxia-induced genes, but whether these sensors affect oxygen-dependent epigenetic regulation more broadly is not known.	Oxygen	247-253	egl-9 family hypoxia inducible factor 2	Homo sapiens	51-57
26159831-4	2015	In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.	Oxygen	38-44	nuclear respiratory factor 1	Homo sapiens	161-165
26390217-6	2015	The increase in UCP1 following 48 hours of isoproterenol increased oxygen consumption rate.	Oxygen	67-73	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	16-20
29398271-5	2018	NOX4 acts as an oxygen sensor, catalysing the reduction of molecular oxygen, mainly to hydrogen peroxide (H2O2).	Oxygen	16-22	NADPH oxidase 4	Homo sapiens	0-4
25976688-9	2015	ILD+PVD patients had increased dead space volume (VD)/tidal volume (VT) and minute ventilation/carbon dioxide production at the anaerobic threshold.In ILD, mPAP-Q"T slope &gt;=3 mmHg min L(-1) is associated with lower peak oxygen consumption, increased VD/VT and inefficient ventilation.	Oxygen	223-229	phospholipid phosphatase 1	Mus musculus	156-160
29398271-5	2018	NOX4 acts as an oxygen sensor, catalysing the reduction of molecular oxygen, mainly to hydrogen peroxide (H2O2).	Oxygen	69-75	NADPH oxidase 4	Homo sapiens	0-4
29065215-7	2018	Gene expression experiments showed that, apart from the conventional nitrogen catabolic repression mechanism that is operating in aerobiosis, there seems to be an oxygen-independent mechanism acting to overexpress key genes like GAP1, GDH1, GDH2 and GLT1 to ensure adequate anaerobic growth even in the presence of non-preferential nitrogen source.	Oxygen	163-169	glutamate synthase (NADH)	Saccharomyces cerevisiae S288C	250-254
26314709-7	2015	Cells lacking Rb1 exhibit defective mitochondria and decreased oxygen consumption.	Oxygen	63-69	RB transcriptional corepressor 1	Homo sapiens	14-17
29054002-7	2018	Density functional theory calculations also reveal that the presence of Vos is responsible for the upshift of valence band maximum and an extended conduction band minimum, hence a valence band width broadening and band gap narrowing which consequently enhance the photocatalytic performance of the oxygen-deficient SnO2-x.	Oxygen	298-304	strawberry notch homolog 1	Homo sapiens	315-318
26339320-8	2015	In this study, we precisely measure the chemotaxis velocity of MCF-7 human breast cancer cells under different oxygen tension conditions towards CXCL12, which is a stromal cell-derived factor.	Oxygen	111-117	C-X-C motif chemokine ligand 12	Homo sapiens	145-151
29357218-3	2018	Herein, oxygen-doped carbon on the surface of reduced graphene oxide (labeled as ODC/rGO) was fabricated to modify the separators of Li-S batteries to limit the dissolution of the lithium polysulfides.	Oxygen	8-14	ornithine decarboxylase 1	Homo sapiens	81-84
25059641-3	2015	Oxygen-bridged dinuclear ruthenium amine complex (Ru360) has been used to study mCU because it is a potent and specific inhibitor of this channel.	Oxygen	0-6	mitochondrial calcium uniporter	Mus musculus	80-83
29357218-5	2018	Moreover, the oxygen-containing groups in ODC/rGO are able to act as chemical adsorption sites to immobilize the lithium polysulfides, suppressing their dissolution in electrolyte to enhance the utilization of sulfur cathode in Li-S batteries.	Oxygen	14-20	ornithine decarboxylase 1	Homo sapiens	42-45
29400318-1	2018	Cytochrome c oxidase (CcO), the terminal oxidase in cellular respiration, couples proton pumping to O2 reduction.	Oxygen	100-102	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
25998464-8	2015	CT2 knockdown reduced basal oxygen consumption without a concomitant increase in glycolysis.	Oxygen	28-34	solute carrier family 22 member 16	Homo sapiens	0-3
29400318-1	2018	Cytochrome c oxidase (CcO), the terminal oxidase in cellular respiration, couples proton pumping to O2 reduction.	Oxygen	100-102	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
28972912-6	2018	Significant rapid decreases in the O2 current during in vivo ischaemic insults in rodent limbs were reported for Pt-Pt (p&lt;0.001) and ClinOX (p&lt;0.01) and for ClinOX (p&lt;0.001) in porcine limbs.	Oxygen	35-37	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	113-118
26001964-4	2015	Correspondingly, PFOA/PFOS treatment induced recruitment of brown adipose tissue mitochondria: increased oxidative capacity and increased UCP1-mediated oxygen consumption (thermogenesis).	Oxygen	152-158	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	138-142
26032740-0	2015	The effect of concentration and duration of normobaric oxygen in reducing caspase-3 and -9 expression in a rat-model of focal cerebral ischaemia.	Oxygen	55-61	caspase 3	Rattus norvegicus	74-90
28972912-8	2018	The Pt-Pt based O2 design demonstrated high sensitivity for tissue ischaemia detection and thus warrants future clinical investigation.	Oxygen	16-18	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	4-9
25920521-7	2015	Inhibition by HLA-class I and HLA-E was also observed with IL-2-activated NK cells and at low oxygen levels (0.6 %) mimicking hypoxic bone marrow niches where myeloma cells preferentially reside.	Oxygen	94-100	major histocompatibility complex, class I, E	Homo sapiens	30-35
25611968-5	2015	The temperature range of available direct rate constant data of the high-temperature key reaction HCO + O2   CO + HO2 has been extended up to 1705 K and confirms a temperature dependence consistent with a dominating direct abstraction channel.	Oxygen	104-106	heme oxygenase 2	Homo sapiens	114-117
29222974-8	2018	We also demonstrated that cytosolic hydrogen peroxide, formed by O2- dismutation, act as an intracellular messenger to specifically activate the Trk/Ras/ERK signaling pathway.	Oxygen	65-67	neurotrophic receptor tyrosine kinase 1	Homo sapiens	145-148
25779083-4	2015	AMPK was not phosphorylated in fibroblasts from FM patients and was associated with decreased mitochondrial biogenesis, reduced oxygen consumption, decreased antioxidant enzymes expression levels and mitochondrial dysfunction.	Oxygen	128-134	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
26177047-5	2015	In the presence of molecular oxygen (O2), hETHE1 oxidizes glutathione persulfide (GSSH) to generate sulfite and reduced glutathione.	Oxygen	29-35	ETHE1 persulfide dioxygenase	Homo sapiens	42-48
28778770-0	2018	B-Type Natriuretic Peptide and Hemoglobin are Two Major Factors Significantly Associated With Baseline Cerebral Oxygen Saturation Measured Using the INVOS Oximeter in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery.	Oxygen	112-118	natriuretic peptide B	Homo sapiens	0-26
26177047-5	2015	In the presence of molecular oxygen (O2), hETHE1 oxidizes glutathione persulfide (GSSH) to generate sulfite and reduced glutathione.	Oxygen	37-39	ETHE1 persulfide dioxygenase	Homo sapiens	42-48
26101896-6	2015	The process prevented Cu(2+) from oxidizing H2O2 to form HO2( )/O2( -) or O2, and enhanced the Cu(+)/Cu(2+) cycle, the formation of ( )OH, and the utilization efficiency of H2O2.	Oxygen	46-48	heme oxygenase 2	Homo sapiens	57-60
25995271-5	2015	In JAR cells, low oxygen tension (1% O2) induced NFAT5 mRNA and increased its nuclear abundance, peaking at 16 h. This increase did not occur in parallel with the earlier HIF1A induction.	Oxygen	18-24	nuclear factor of activated T cells 5	Homo sapiens	49-54
25995271-5	2015	In JAR cells, low oxygen tension (1% O2) induced NFAT5 mRNA and increased its nuclear abundance, peaking at 16 h. This increase did not occur in parallel with the earlier HIF1A induction.	Oxygen	37-39	nuclear factor of activated T cells 5	Homo sapiens	49-54
25361084-7	2015	SiRNA-mediated abrogation of the glucocorticoid induction of PGC-1alpha in vitro abolished the effect of glucocorticoid on myofibril structure and mitochondrial oxygen consumption.	Oxygen	161-167	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	61-71
26075742-12	2015	There were also significant effects due to oxygen tension on gene expression, wherein there was greater collagen type I, collagen type II, SOX9 and less MMP13 expression on tissue culture plastic compared to synoviocyte matrix.	Oxygen	43-49	SRY-box transcription factor 9	Homo sapiens	139-143
28322447-4	2018	Previous studies show that global knockout of CRTC3 enhances oxygen consumption and energy expenditure and subsequently protects the knockout animal against obesity.	Oxygen	61-67	CREB regulated transcription coactivator 3	Homo sapiens	46-51
25809665-5	2015	In the presence of O2, the alpha subunits are hydroxylated by specific prolyl-4-hydroxylase domain proteins (PHD1, PHD2, and PHD3) and an asparaginyl hydroxylase (factor inhibiting HIF-1, FIH-1).	Oxygen	19-21	egl-9 family hypoxia inducible factor 2	Homo sapiens	109-113
29286583-4	2018	By controlling the sulfidation process during the formation of Nix Sy -NSCs, Ni9 S8 -NSCs, Ni9 S8 -NiS1.03 -NSCs, and NiS1.03 -NSCs are obtained, respectively, giving rise to the increase of high-valence Ni component, and resulting in gradually enhanced oxygen evolution reaction electrocatalytic activities.	Oxygen	254-260	BCL2 interacting protein 3 like	Homo sapiens	63-66
25750127-6	2015	Introduction of a single oxygen atom change into polySia by exogenous feeding of the non-neural sialic acid Neu5Gc (N-glycolylneuraminic acid) caused resistance to Neu1-induced polySia turnover and also inhibited the associated release of brain-derived neurotrophic factor.	Oxygen	25-31	neuraminidase 1	Mus musculus	164-168
29416550-11	2018	Endogenous CGRP was elevated in the lung tissues of premature rats exposed to 95% oxygen.	Oxygen	82-88	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
25919989-5	2015	The observations are discussed in terms of modulations on the intrinsic electrostriction in LAO/STO by an electric field induced by nonuniform distribution of either oxygen vacancies in the bulk or ionic adsorbates on the surface of LAO.	Oxygen	166-172	interleukin 4 induced 1	Homo sapiens	92-95
25795103-6	2015	RESULTS: Patients with FM showed a higher increase in blood oxygen level dependent (BOLD) response, particularly in the supplementary motor area (SMA).	Oxygen	60-66	survival of motor neuron 1, telomeric	Homo sapiens	146-149
26136895-9	2015	The reflex decrease in CGRP may be caused by germ cell apoptosis, decreased blood flow and oxygen levels, and the increase in reactive oxygen free radicals and lipid peroxidation.	Oxygen	91-97	calcitonin-related polypeptide alpha	Rattus norvegicus	23-27
26136895-9	2015	The reflex decrease in CGRP may be caused by germ cell apoptosis, decreased blood flow and oxygen levels, and the increase in reactive oxygen free radicals and lipid peroxidation.	Oxygen	135-141	calcitonin-related polypeptide alpha	Rattus norvegicus	23-27
25596185-1	2015	The ethylmalonic encephalopathy protein 1 (ETHE1) catalyses the oxygen-dependent oxidation of glutathione persulfide (GSSH) to give persulfite and glutathione.	Oxygen	64-70	ETHE1 persulfide dioxygenase	Homo sapiens	4-41
25596185-1	2015	The ethylmalonic encephalopathy protein 1 (ETHE1) catalyses the oxygen-dependent oxidation of glutathione persulfide (GSSH) to give persulfite and glutathione.	Oxygen	64-70	ETHE1 persulfide dioxygenase	Homo sapiens	43-48
25652847-3	2015	Second, deletion of Nox4, via an enhanced angiopoietin 1 expression, contributes to stabilization of new formed vessels and prevents an exacerbated neo-angiogenesis in oxygen-induced retinopathy.	Oxygen	168-174	NADPH oxidase 4	Mus musculus	20-24
25460879-4	2015	The biocathode contained MvBOx directly adsorbed to the deposited gold nanoparticles for cathodic oxygen reduction starting at 0.71V vs. NHE.	Oxygen	98-104	solute carrier family 9 member C1	Homo sapiens	137-140
25849590-7	2015	TGF-beta1 treatment was associated with an increase in mitochondrial function with a twofold increase in baseline oxygen consumption rate (2.25 +- 0.03 vs. 1.13 +- 0.1 nmol O2/min/106 cells) and FCCP-induced mitochondrial respiration (2.87 +- 0.03 vs. 1.46 +- 0.15 nmol O2/min/106 cells).	Oxygen	114-120	transforming growth factor, beta 1	Mus musculus	0-9
25849590-7	2015	TGF-beta1 treatment was associated with an increase in mitochondrial function with a twofold increase in baseline oxygen consumption rate (2.25 +- 0.03 vs. 1.13 +- 0.1 nmol O2/min/106 cells) and FCCP-induced mitochondrial respiration (2.87 +- 0.03 vs. 1.46 +- 0.15 nmol O2/min/106 cells).	Oxygen	173-175	transforming growth factor, beta 1	Mus musculus	0-9
25849590-7	2015	TGF-beta1 treatment was associated with an increase in mitochondrial function with a twofold increase in baseline oxygen consumption rate (2.25 +- 0.03 vs. 1.13 +- 0.1 nmol O2/min/106 cells) and FCCP-induced mitochondrial respiration (2.87 +- 0.03 vs. 1.46 +- 0.15 nmol O2/min/106 cells).	Oxygen	270-272	transforming growth factor, beta 1	Mus musculus	0-9
25694541-3	2015	In this work, the subsequent reoxygenation of cells after hypoxia is shown to lead to increased levels of oxygen-bound myoglobin relative to the initial levels observed under normoxic conditions.	Oxygen	31-37	myoglobin	Rattus norvegicus	119-128
25578653-3	2015	Manganese superoxide dismutase (MnSOD), a primary mitochondrial antioxidant in mammals, has long been known to play a crucial role in radioadaptive protection by detoxifying O2( -) generated by mitochondrial oxidative phosphorylation.	Oxygen	174-176	superoxide dismutase 2	Homo sapiens	0-30
25578653-3	2015	Manganese superoxide dismutase (MnSOD), a primary mitochondrial antioxidant in mammals, has long been known to play a crucial role in radioadaptive protection by detoxifying O2( -) generated by mitochondrial oxidative phosphorylation.	Oxygen	174-176	superoxide dismutase 2	Homo sapiens	32-37
25619142-6	2015	Singlet-oxygen-dependent activation of the FAS receptor and caspase-8 increased superoxide anion generation by NOX1 and amplification of singlet oxygen generation, which allowed singlet-oxygen-dependent inactivation of catalase.	Oxygen	8-14	caspase 8	Homo sapiens	60-69
25619142-6	2015	Singlet-oxygen-dependent activation of the FAS receptor and caspase-8 increased superoxide anion generation by NOX1 and amplification of singlet oxygen generation, which allowed singlet-oxygen-dependent inactivation of catalase.	Oxygen	8-14	NADPH oxidase 1	Homo sapiens	111-115
25619142-6	2015	Singlet-oxygen-dependent activation of the FAS receptor and caspase-8 increased superoxide anion generation by NOX1 and amplification of singlet oxygen generation, which allowed singlet-oxygen-dependent inactivation of catalase.	Oxygen	145-151	caspase 8	Homo sapiens	60-69
25660488-4	2015	The complexes, Cu(HL1)2 and Cu(HL2)2 0.5H2O, have flat square geometry with oxygen atoms in the first coordination sphere.	Oxygen	76-82	intelectin 2	Homo sapiens	31-34
25253897-9	2015	CCL-18 negatively correlated with diffusion capacity of carbon monoxide (DLCO), arterial oxygen (PaO2) and mean arterial carbon dioxide (PaCO2) (P &lt; 0.05) and CRP negatively correlated with DLCO, PaO2, sleep SaO2 and oxygen uptake (VO2) during exercise (P &lt; 0.05).	Oxygen	89-95	C-C motif chemokine ligand 18	Homo sapiens	0-6
25662501-9	2015	The findings indicate that the protective effect of C60(OH)10/HP-beta-CD nanoparticles was due to the suppression of oxidative stress in mitochondria, as the result of scavenging ROS such as O2( -), NO and peroxynitrite, which act as critical mediators in the liver injuries.	Oxygen	191-193	beta-carotene oxygenase 1	Mus musculus	65-72
25697095-8	2015	A survey of ubiquinone analogues revealed that menadione, duroquinone, and CoQ1 reacted more efficiently than oxygen as the terminal electron acceptor during catalysis.	Oxygen	110-116	decaprenyl diphosphate synthase subunit 1	Homo sapiens	75-79
25315650-11	2015	CONCLUSIONS: IR and A2aR stimulation produces pathological and protected liver cell phenotypes, respectively characterized by down- and upregulation of proteins involved in the response to O2 and nutrients deprivation during ischemia, oxidative stress, and reactivation of aerobic energy synthesis at reperfusion.	Oxygen	189-191	adenosine A2a receptor	Mus musculus	20-24
25672499-6	2015	In PAH, acquired mitochondrial abnormalities, including epigenetic silencing of superoxide dismutase (SOD2), disrupt oxygen sensing creating a pseudo-hypoxic environment characterized by normoxic activation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	117-123	superoxide dismutase 2	Homo sapiens	102-106
25537499-1	2015	UV photolysis of the nitridoosmate(VIII) anion, OsO3 N(-) , in low-temperature frozen matrices results in nitrogen-oxygen bond formation to give the Os(II) nitrosyl complex OsO2 (NO)(-) .	Oxygen	115-121	cytochrome c oxidase subunit 8A	Homo sapiens	35-39
25311524-9	2015	The results indicate that substitution of sulfur by nitrogen or oxygen in BDT unit, and silicon or phosphor in TT unit of pristine PTB7 leads to a higher eta as well as Deltamuge.	Oxygen	64-70	endothelin receptor type A	Homo sapiens	154-157
25478809-5	2015	Par2, detected mostly in retinal ganglion cells, was up-regulated in oxygen-induced retinopathy.	Oxygen	69-75	F2R like trypsin receptor 1	Homo sapiens	0-4
24691248-1	2015	BACKGROUND: Although pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest, the evidence of its effects on dynamic hyperinflation (DH) and exercise tolerance is scarce.	Oxygen	106-112	phospholamban	Homo sapiens	43-46
24691248-12	2015	At isotime, PLB yielded higher inspiratory capacity (IC) and oxygen saturation (1.19 +- 0.33 to 1.35 +- 0.39 L; P &lt; 0.05 and 93.1 +- 4.6 to 94.0 +- 4.1%; P&lt;0.05), and lower respiratory rate than CB only in Improver.	Oxygen	61-67	phospholamban	Homo sapiens	12-15
25022804-10	2015	Early oxygen therapies prevented occludin degradation, MMP-9 activation, and reduced HIF-1alpha expression.	Oxygen	6-12	matrix metallopeptidase 9	Mus musculus	55-60
25522366-7	2015	For a biosensor with the glucose dehydrogenase (GDH; oxygen-independent catalysis) enzyme, the response of the semiconducting SWNT-GDH electrode was 4 times larger than that of the metallic SWNT-GDH electrode.	Oxygen	53-59	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	25-46
25522366-7	2015	For a biosensor with the glucose dehydrogenase (GDH; oxygen-independent catalysis) enzyme, the response of the semiconducting SWNT-GDH electrode was 4 times larger than that of the metallic SWNT-GDH electrode.	Oxygen	53-59	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	48-51
25860187-3	2015	At all three temperatures, the major stable product species is propene, formed in the propyl + O2 reactions by direct HO2 elimination from both n- and i-propyl peroxy radicals.	Oxygen	95-97	heme oxygenase 2	Homo sapiens	118-121
25997945-2	2015	In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine deaminase (ADA).	Oxygen	15-21	5' nucleotidase, ecto	Rattus norvegicus	119-123
25997945-3	2015	The cell-surface endopeptidase CD26 controls the concentration of vasoactive and antioxidant peptides and hence regulates the oxygen supply to tissues and oxidative stress response.	Oxygen	126-132	dipeptidylpeptidase 4	Rattus norvegicus	31-35
25997945-10	2015	Thus a high oxygen level tended to downregulate the adenosinergic pathway and CD26 activity.	Oxygen	12-18	dipeptidylpeptidase 4	Rattus norvegicus	78-82
25496235-8	2015	Lower respiratory volumes and pressures, abnormalities in AGA, night oxygen desaturation and higher EtCO2 are present in DM2, but are less pronounced than in the DM1 population.	Oxygen	69-75	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	121-124
26717730-3	2015	Since the spin-orbit coupling parameter r (150 cm(-1)) of ligand O2- is close to that xip(0) ( 248 cm(-1)) of the central 3d(1) ion in zinc phosphate glass doped VO2+, the effect of the spin-orbit coupling parameter xip(0) on the EPR spectra and optical absorption spectra should be taken into account.	Oxygen	65-67	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	86-89
26717730-3	2015	Since the spin-orbit coupling parameter r (150 cm(-1)) of ligand O2- is close to that xip(0) ( 248 cm(-1)) of the central 3d(1) ion in zinc phosphate glass doped VO2+, the effect of the spin-orbit coupling parameter xip(0) on the EPR spectra and optical absorption spectra should be taken into account.	Oxygen	65-67	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	216-219
25816104-8	2015	RESULTS: The oxygen transfer function was significantly lower in patients in the BOS 0p (P = .025) and BOS 1-3 groups (P = .003) than it was in the patients with BOS 0.	Oxygen	13-19	EYA transcriptional coactivator and phosphatase 1	Homo sapiens	103-108
25936780-3	2015	Oxygen negatively regulates NDRG3 expression at the protein level via the PHD2/VHL system, whereas lactate, produced in excess under prolonged hypoxia, blocks its proteasomal degradation by binding to NDRG3.	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	79-82
25759262-6	2015	Accordingly, long-lived isp-1 and clk-1 mutants that demonstrate decreased levels of oxygen consumption showed a shorter established period of adaptation than N2 nematodes, whereas short-lived gas-1 and mev-1 mutants that have a hypersensitive response to oxygen showed a longer period of adaptation than the N2.	Oxygen	85-91	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Caenorhabditis elegans	24-29
25759262-6	2015	Accordingly, long-lived isp-1 and clk-1 mutants that demonstrate decreased levels of oxygen consumption showed a shorter established period of adaptation than N2 nematodes, whereas short-lived gas-1 and mev-1 mutants that have a hypersensitive response to oxygen showed a longer period of adaptation than the N2.	Oxygen	85-91	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	34-39
25985258-1	2015	The water-soluble cationic nickel(II) complex of meso-tetrakis(4-N-methylpyridyl)porphyrin (1) can electrocatalyze water oxidation to O2 in neutral aqueous solution (pH 7.0) with the onset of the catalytic wave appearing at ~1.0 V (vs NHE).	Oxygen	134-136	solute carrier family 9 member C1	Homo sapiens	235-238
25234622-5	2015	GO oxygen groups were identified as nucleation sites for the formation of the MOF crystals.	Oxygen	3-9	lysine acetyltransferase 8	Homo sapiens	78-81
25578474-5	2015	We demonstrate in mice with HSC-specific conditional deletion of the Hif1a gene that the oxygen-labile transcription factor HIF-1alpha is essential for HSC mobilization in response to G-CSF and Plerixafor.	Oxygen	89-95	colony stimulating factor 3 (granulocyte)	Mus musculus	184-189
25522366-7	2015	For a biosensor with the glucose dehydrogenase (GDH; oxygen-independent catalysis) enzyme, the response of the semiconducting SWNT-GDH electrode was 4 times larger than that of the metallic SWNT-GDH electrode.	Oxygen	53-59	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	131-134
25522366-7	2015	For a biosensor with the glucose dehydrogenase (GDH; oxygen-independent catalysis) enzyme, the response of the semiconducting SWNT-GDH electrode was 4 times larger than that of the metallic SWNT-GDH electrode.	Oxygen	53-59	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	131-134
29128627-0	2018	Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and glucose deprivation and reoxygenation.	Oxygen	81-87	microRNA 708	Homo sapiens	22-34
25584894-1	2015	A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.	Oxygen	134-140	acyl-CoA synthetase short chain family member 2	Homo sapiens	58-81
25584894-1	2015	A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.	Oxygen	134-140	acyl-CoA synthetase short chain family member 2	Homo sapiens	83-88
25044272-8	2015	miR-210 was significantly increased in cultured hPASMCs exposed to 1% O2 hypoxia for 48 h, as was MKP-1 mRNA and protein expression.	Oxygen	70-72	microRNA 210	Homo sapiens	0-7
25714978-4	2015	The interaction of leucine-rich repeat kinase and Fas- Associated protein with Death Domain has been implicated in the switching-on of the extrinsic apoptotic pathway via caspase-8 activation, while deficiency in PTEN induced putative kinase 1 has been shown to cause Ca2+ accumulation in mitochondria, increased generation of reactive oxygen species and intrinsic cell death.	Oxygen	336-342	caspase 8	Homo sapiens	171-180
25896762-0	2015	MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8/SVneo cell invasion by directly down regulating CXCL12 under low oxygen conditions.	Oxygen	129-135	C-X-C motif chemokine ligand 12	Homo sapiens	112-118
25896762-8	2015	Our results suggest that miR-135b and CXCL12 play important roles in modulating the EVT invasion under low oxygen conditions.	Oxygen	107-113	C-X-C motif chemokine ligand 12	Homo sapiens	38-44
25394489-10	2015	Mechanistically, suppression of Bnip3 following PTEN loss is likely due to reduction of hypoxia-inducible factor-2alpha (HIF-2alpha) because forced expression of an oxygen-stable HIF-2alpha mutant rescues Bnip3 expression and apoptosis.	Oxygen	165-171	BCL2/adenovirus E1B interacting protein 3	Mus musculus	32-37
25638408-0	2015	PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy.	Oxygen	92-98	insulin-like growth factor 1	Mus musculus	40-45
29128627-3	2018	In this study, we have investigated the effects of microRNA-708 (miR-708) on cell survival of oxygen and glucose-deprived reoxygenation (OGD/R) human neuroblastoma cells (SH-SY5Y) and explored whether miR-708 inhibited neuronal death by targeting JAK1.	Oxygen	94-100	microRNA 708	Homo sapiens	51-63
29128627-3	2018	In this study, we have investigated the effects of microRNA-708 (miR-708) on cell survival of oxygen and glucose-deprived reoxygenation (OGD/R) human neuroblastoma cells (SH-SY5Y) and explored whether miR-708 inhibited neuronal death by targeting JAK1.	Oxygen	94-100	microRNA 708	Homo sapiens	65-72
25405669-2	2015	RECENT FINDINGS: beta2-agonist heliox-driven nebulization significantly increased by 17% [95% confidence interval (CI) 5.2-29.4] peak expiratory flow, and decreased the rate of hospital admissions (risk ratio 0.77, 95% CI 0.62-0.98), compared with oxygen-driven nebulization.	Oxygen	248-254	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-22
28983994-2	2018	Herein we show that daily beta2 -agonist treatment attenuates training-induced enhancements in exercise performance and maximal oxygen consumption, and alters muscle proteome signature and phenotype in trained young men.	Oxygen	128-134	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	26-31
25866826-0	2015	NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy.	Oxygen	119-125	NADPH oxidase 4	Mus musculus	0-15
25866826-0	2015	NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy.	Oxygen	119-125	kinase insert domain protein receptor	Mus musculus	92-107
25686096-11	2015	Considering the function of CYGB as O2 carrier, these results strongly support the hypothesis that HSCs are involved in the CYP2E1-mediated xenobiotic activation by augmenting O2 supply to hepatocytes.	Oxygen	36-38	cytoglobin	Mus musculus	28-32
25686096-12	2015	In conclusion, CYGB in HSCs contributes to the CYP-mediated metabolism of xenobiotics in hepatocytes by supplying O2 for enzymatic oxidation.	Oxygen	114-116	cytoglobin	Mus musculus	15-19
25849610-1	2015	A planar tetracoordinated oxygen containing a homochiral metal-organic framework (MOF) has been synthesized and characterized that can be used as a new chiral stationary phase in high-performance liquid chromatography to efficiently separate racemates such as pharmaceutically important (+-)-ibuprofen and (+-)-1-phenyl-1,2-ethanediol.	Oxygen	26-32	lysine acetyltransferase 8	Homo sapiens	57-86
28983994-12	2018	beta2 -Agonist attenuated training-induced enhancements in maximal oxygen consumption (P &lt;= 0.01) and exercise performance (6.1 vs. 11.6%, P &lt;= 0.05) in HIT+beta2 A compared to HIT.	Oxygen	67-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
29172489-0	2018	Ligand-Directed Reactivity in Dioxygen and Water Binding to cis-[Pd(NHC)2(eta2-O2)].	Oxygen	30-38	DNA polymerase iota	Homo sapiens	74-78
25900831-2	2015	O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-gamma-lyase (CSE).	Oxygen	0-2	cystathionase (cystathionine gamma-lyase)	Mus musculus	139-164
25900831-2	2015	O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-gamma-lyase (CSE).	Oxygen	0-2	cystathionase (cystathionine gamma-lyase)	Mus musculus	166-169
25900831-6	2015	In carotid bodies from mice lacking HO-2, compensatory increased abundance of nNOS (neuronal nitric oxide synthase) mediated O2 sensing through PKG-dependent regulation of H2S by nitric oxide.	Oxygen	125-127	nitric oxide synthase 1, neuronal	Mus musculus	78-82
25900831-6	2015	In carotid bodies from mice lacking HO-2, compensatory increased abundance of nNOS (neuronal nitric oxide synthase) mediated O2 sensing through PKG-dependent regulation of H2S by nitric oxide.	Oxygen	125-127	nitric oxide synthase 1, neuronal	Mus musculus	84-114
25707467-0	2015	Respiratory conservation of energy with dioxygen: cytochrome C oxidase.	Oxygen	40-48	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	50-70
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Oxygen	95-101	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Oxygen	95-101	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Oxygen	103-105	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
25707467-1	2015	Cytochrome c oxidase (CcO) is the terminal oxidase of cell respiration which reduces molecular oxygen (O2) to H2O coupled with the proton pump.	Oxygen	103-105	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
25660294-7	2015	Activation of HLA3 expression in high CO2 acclimated cells, where HLA3 is not expressed, resulted in increased Ci accumulation and Ci-dependent photosynthetic O2 evolution specifically in very low CO2 concentrations, which confirms that HLA3 is indeed involved in Ci uptake, and suggests it is mainly associated with HCO3(-) transport in very low CO2 concentrations, conditions in which active CO2 uptake is highly limited.	Oxygen	39-41	uncharacterized protein	Chlamydomonas reinhardtii	14-18
25600958-0	2015	Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.	Oxygen	40-46	interleukin 23, alpha subunit p19	Mus musculus	17-36
25600958-0	2015	Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.	Oxygen	40-46	interleukin 23, alpha subunit p19	Mus musculus	100-105
25533676-2	2015	VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation.	Oxygen	66-72	von Hippel-Lindau tumor suppressor	Homo sapiens	31-35
25593505-1	2014	PURPOSE: The inhibition of GSK-3beta blocks mitochondrial membrane permeability transition (mMPT) for HLE-B3 cells in atmospheric oxygen.	Oxygen	130-136	glycogen synthase kinase 3 beta	Homo sapiens	27-36
25550320-6	2015	This reduced oxygen concentration leads to a deterioration of renal function, an increase in renal inflammation, and significantly more tubular damage and apoptosis in the kidneys of wild-type (Morg1(+/+)) mice.	Oxygen	13-19	WD repeat domain containing 83	Mus musculus	194-199
29172489-1	2018	Reaction of [Pd(IPr)2] (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) and O2 leads to the surprising discovery that at low temperature the initial reaction product is a highly labile peroxide complex cis-[Pd(IPr)2(eta2-O2)].	Oxygen	84-86	DNA polymerase iota	Homo sapiens	224-228
25360456-0	2014	Efficient oxygen reduction by nanocomposites of heterometallic carbide and nitrogen-enriched carbon derived from the cobalt-encapsulated indium-MOF.	Oxygen	10-16	lysine acetyltransferase 8	Homo sapiens	144-147
29172489-4	2018	In addition to reaction with O2, cis-[Pd(IPr)2(eta2-O2)] reacts at low temperature with H2O in methanol/ether solution to form trans-[Pd(IPr)2(OH)(OOH)].	Oxygen	29-31	DNA polymerase iota	Homo sapiens	47-54
29172489-7	2018	The increased reactivity of cis-[Pd(IPr)2(eta2-O2)] is attributed to the enthalpy of binding of O2 to [Pd(IPr)2] (-14.5 +- 1.0 kcal/mol) that is approximately one-half that of [Pd(IMes)2] (-27.9 +- 1.5 kcal/mol).	Oxygen	47-49	DNA polymerase iota	Homo sapiens	42-46
26064225-0	2015	Temporal and spatial changes in VEGF, alphaA- and alphaB-crystallin expression in a mouse model of oxygen-induced retinopathy.	Oxygen	99-105	crystallin, alpha B	Mus musculus	50-67
29545920-7	2018	Hypoxia (1% O2) upregulated CD86, CD274, HLA-DR, and CD54, and downregulated CD40 and CD83 in DCs as compared to normoxia (21% O2).	Oxygen	12-14	CD86 molecule	Homo sapiens	28-32
25586178-9	2015	Although we identified Duox1 A-loop residues (His(1071), His(1072), and Gly(1074)) important for reducing O2 (-) release, mutations of these residues to those of Duox2 failed to convert Duox1 to an O2 (-)-releasing enzyme.	Oxygen	106-108	dual oxidase 1	Homo sapiens	23-28
25525167-0	2014	Regulation of fibroblast growth factor 2 expression in oxygen-induced retinopathy.	Oxygen	55-61	fibroblast growth factor 2	Mus musculus	14-40
25525167-2	2014	The purpose of the current study was to determine the transcriptional and translational regulation of FGF2 expression in oxygen-induced retinopathy (OIR), the animal model of ROP.	Oxygen	121-127	fibroblast growth factor 2	Mus musculus	102-106
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	26-28	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	54-57
29545920-7	2018	Hypoxia (1% O2) upregulated CD86, CD274, HLA-DR, and CD54, and downregulated CD40 and CD83 in DCs as compared to normoxia (21% O2).	Oxygen	12-14	CD40 molecule	Homo sapiens	77-81
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	26-28	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	338-341
25552662-5	2015	We determined that 1) low O2-induced ATP release from DM2 erythrocytes is rescued by C-peptide in the presence and absence of insulin, 2) the signaling pathway activated by C-peptide in human erythrocytes involves PKC, as well as soluble guanylyl cyclase (sGC) and 3) inhibitors of cGMP degradation rescue low O2-induced ATP release from DM2 erythrocytes.	Oxygen	310-312	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	54-57
25519840-12	2014	Under hypoxic conditions (3% oxygen) both ASCs and BM MSCs demonstrate increased RNA expression of H19 and Vascular endothelial growth factor A.	Oxygen	29-35	H19, imprinted maternally expressed transcript	Mus musculus	99-102
25519840-13	2014	Importantly, ASC gene expression is significantly less variable than BM MSCs under both oxygen conditions, indicating to their superior homogeneity.	Oxygen	88-94	steroid sulfatase	Mus musculus	13-16
25552662-7	2015	In addition, since both C-peptide and phosphodiesterase 5 inhibitors rescue low O2-induced ATP release from erythrocytes of humans with DM2, their administration to humans with DM2 could aid in the treatment and/or prevention of the vascular disease associated with this condition.	Oxygen	80-82	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	136-139
29298419-0	2018	Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.	Oxygen	0-6	eukaryotic translation initiation factor 5B	Homo sapiens	68-73
25552662-7	2015	In addition, since both C-peptide and phosphodiesterase 5 inhibitors rescue low O2-induced ATP release from erythrocytes of humans with DM2, their administration to humans with DM2 could aid in the treatment and/or prevention of the vascular disease associated with this condition.	Oxygen	80-82	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	177-180
25480159-12	2015	Interleukin-10 treatment suppressed activities of matrix metalloproteinase 2 and matrix metalloproteinase 9 and reduced lung permeability in mice during oxygen exposure.	Oxygen	153-159	matrix metallopeptidase 9	Mus musculus	81-107
25514679-6	2014	Immature SP-B, SP-A, SP-D and RAGE values were related to DLCO, peak oxygen consumption, ventilatory efficiency, and brain natriuretic peptide (BNP), whereas plasma mature SP-B was not.	Oxygen	69-75	surfactant protein B	Homo sapiens	9-13
25361009-4	2014	Here, we show that phospholipase D1 (PLD1) protein itself acts as a molecular platform, interacting directly with HIF-1alpha, PHD, and VHL, thereby dynamically assembling a multiprotein complex that mediates efficient degradation of HIF-1alpha in an O2-dependent manner.	Oxygen	250-252	von Hippel-Lindau tumor suppressor	Homo sapiens	135-138
29298419-7	2018	We suggest that aerobic eukarya retained eIF5B/IF2 to remodel anaerobic pathways during episodes of oxygen deficiency.	Oxygen	100-106	eukaryotic translation initiation factor 5B	Homo sapiens	41-46
25505325-3	2014	Previous studies showed that a hexacoordinated globin called GLB-5 tunes the dynamic range of O2-sensing neurons in natural C. elegans isolates, but is defective in the N2 lab reference strain (McGrath et al., 2009; Persson et al., 2009).	Oxygen	94-96	GLOBIN domain-containing protein	Caenorhabditis elegans	61-66
25505325-4	2014	GLB-5 enables a sharp behavioral switch when O2 changes between 21 and 17%.	Oxygen	45-47	GLOBIN domain-containing protein	Caenorhabditis elegans	0-5
25505325-7	2014	Forward genetic screens indicate that GLB-5"s effects on O2 sensing require PDL-1, the C. elegans ortholog of mammalian PrBP/PDE6delta protein.	Oxygen	57-59	GLOBIN domain-containing protein	Caenorhabditis elegans	38-43
25505325-13	2014	Our data suggest GLB-5 and the soluble guanylate cyclases operate in close proximity to sculpt O2 responses.	Oxygen	95-97	GLOBIN domain-containing protein	Caenorhabditis elegans	17-22
25358120-1	2014	Some oxygen-bonded substituents were investigated as leaving groups in photoinduced ArS(N)1 reactions.	Oxygen	5-11	RIEG2	Homo sapiens	84-87
25578537-6	2015	The expression pattern of glycolytic genes (HK, PFK and G6PDH) indicated that oocytes and embryos under 5% O2 tend to follow anaerobic glycolysis and pentose phosphate pathways to support optimum embryo development.	Oxygen	107-109	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	56-61
25578537-8	2015	Further, less G6PDH expression at 20% O2 was indicative of lower pentose phosphate activity.	Oxygen	38-40	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	14-19
25550200-2	2015	SPR also mediates chemical redox cycling, catalyzing one-electron reduction of redox-active chemicals, including quinones and bipyridinium herbicides (e.g., menadione, 9,10-phenanthrenequinone, and diquat); rapid reaction of the reduced radicals with molecular oxygen generates reactive oxygen species (ROS).	Oxygen	261-267	sepiapterin reductase	Rattus norvegicus	0-3
25398259-7	2015	Although the oxygen level is affected by the blood flow through the foramen ovale, the oxygen saturation in newborns with TGA was even lower (43.2 %).	Oxygen	13-19	T-box transcription factor 1	Homo sapiens	122-125
29298419-7	2018	We suggest that aerobic eukarya retained eIF5B/IF2 to remodel anaerobic pathways during episodes of oxygen deficiency.	Oxygen	100-106	eukaryotic translation initiation factor 5B	Homo sapiens	47-50
25398259-7	2015	Although the oxygen level is affected by the blood flow through the foramen ovale, the oxygen saturation in newborns with TGA was even lower (43.2 %).	Oxygen	87-93	T-box transcription factor 1	Homo sapiens	122-125
26636134-0	2014	Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy.	Oxygen	71-77	secreted acidic cysteine rich glycoprotein	Mus musculus	12-17
26636134-2	2014	PURPOSE: To characterize the changes in SPARC expression and effect of its deletion in a mouse model Oxygen Induced Retinopathy (OIR).	Oxygen	101-107	secreted acidic cysteine rich glycoprotein	Mus musculus	40-45
30357742-4	2018	Because ERbeta is localized in mitochondria, and because estradiol and ERbeta agonist increase mitochondrial O2 consumption, we assessed the mitochondrial respiration (with a high-resolution oxygraph system) and the in vitro activity of the complex I of the electron transfer chain in samples of brain cortex in aged wild-type and ERbetaKO female mice.	Oxygen	109-111	estrogen receptor 2 (beta)	Mus musculus	71-77
25114170-5	2014	In liver mitochondria from Ad-Acot2 mice, phosphorylating O2 consumption was higher with lipid substrate, but not with nonlipid substrate.	Oxygen	58-60	acyl-CoA thioesterase 2	Mus musculus	30-35
25462805-9	2015	The oxygen affinity of extracted cow Mb (P50=3.72+-0.16 mmHg) was not statistically different from commercially prepared horse heart Mb (P50=3.71+-0.10 mmHg).	Oxygen	4-10	myoglobin	Bos taurus	37-39
25462805-10	2015	With high yield Mb extraction and fast generation of an oxygen dissociation curve, it was possible to consistently determine Mb P50 under physiologically relevant conditions for endothermic vertebrates.	Oxygen	56-62	myoglobin	Bos taurus	125-127
29165041-5	2018	The phosphorylation of ATG4B at Ser34 had little effect on autophagic flux, but promoted the Warburg effect including the increase of L-lactate production and glucose consumption, and the decrease of oxygen consumption in HCC cells.	Oxygen	200-206	autophagy related 4B cysteine peptidase	Homo sapiens	23-28
25503277-6	2015	We investigate the specificity and detection limit of the platform and quantify miR-210 levels in RNA extracts of cells cultured under different oxygen tensions.	Oxygen	145-151	microRNA 210	Homo sapiens	80-87
25266655-2	2014	We show here that hypoxia (low glucose and oxygen) triggers a rearrangement of the 14-3-3zeta interactome to favor an interaction with the core autophagy regulator Atg9A.	Oxygen	43-49	autophagy related 9A	Homo sapiens	164-169
29061366-6	2018	The numbers of caspase-3-positive cells in both cortical layer 3 and the CA1 region in the hippocampus in the 6 h anesthesia exposure group with 21% oxygen were increased compared with the 6 h anesthesia exposure with 30% oxygen and control groups.	Oxygen	149-155	caspase 3	Rattus norvegicus	15-24
25078107-5	2014	Hypoxic conditions (1% O2 or hypoxia mimics) induced a reduction of YAP phosphorylation (S127) and total YAP expression in EOC cell lines OVCAR5 and SKOV3.	Oxygen	23-25	Yes1 associated transcriptional regulator	Homo sapiens	68-71
25078107-5	2014	Hypoxic conditions (1% O2 or hypoxia mimics) induced a reduction of YAP phosphorylation (S127) and total YAP expression in EOC cell lines OVCAR5 and SKOV3.	Oxygen	23-25	Yes1 associated transcriptional regulator	Homo sapiens	105-108
25194803-2	2015	A sensor system comprising an optical glucose biosensor and an optical oxygen sensor is integrated into the insulin infusion catheter of an insulin pump.	Oxygen	71-77	insulin	Sus scrofa	108-115
29061366-6	2018	The numbers of caspase-3-positive cells in both cortical layer 3 and the CA1 region in the hippocampus in the 6 h anesthesia exposure group with 21% oxygen were increased compared with the 6 h anesthesia exposure with 30% oxygen and control groups.	Oxygen	222-228	caspase 3	Rattus norvegicus	15-24
25519729-2	2015	Mammalian COX4-2 is thought to have a role in relation to fine-tuning metabolism in low oxygen levels, conferred through both structural differences in the subunit protein structure and regulatory differences in the gene.	Oxygen	88-94	cytochrome c oxidase subunit 4I2	Homo sapiens	10-16
29694982-9	2018	Furthermore, HS-fed UCP3-/-mice experienced more severe mitochondrial respiratory dysfunction compared with HS-fed C57BL/6 mice, represented by the decreased volume of oxygen consumption and heat production at the whole-body level.	Oxygen	168-174	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	20-24
24934629-2	2015	Tissue oxygen saturation measurement (TOx) with near-infrared spectrophotometry (NIRS) is a method used for this purpose.	Oxygen	7-13	thymocyte selection associated high mobility group box	Homo sapiens	38-41
25440060-2	2014	Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1alpha and Hif-2alpha) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-alpha signaling.	Oxygen	4-10	von Hippel-Lindau tumor suppressor	Homo sapiens	41-44
28786347-5	2018	RESULTS: By modulating membrane potential, cell volume, Ca2+ signals and the respiratory chain, KCa3.1 channels in both, plasma and inner mitochondrial membrane, have been demonstrated to regulate many cellular processes such as migration and tissue invasion, metastasis, cell cycle progression, oxygen consumption and metabolism, DNA damage response and cell death of cancer cells.	Oxygen	296-302	potassium calcium-activated channel subfamily N member 4	Homo sapiens	96-102
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	matrix metallopeptidase 9	Mus musculus	75-80
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	matrix metallopeptidase 9	Mus musculus	172-177
24989775-2	2014	The BKCa-channel contains response elements for CO, O2, and CO2.	Oxygen	52-54	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	4-8
24965004-3	2014	During radiolysis of aerated solutions hydroxyl radical (( )OH), eaq (-), H( ) and O2 ( -)/HO2 ( ) reactive intermediates are produced, the degradation of solute takes place practically entirely through ( )OH reactions.	Oxygen	83-85	heme oxygenase 2	Homo sapiens	91-94
25472694-8	2015	In conclusion, we found that bulls with the ETFA TT genotype produce sperm with the highest glutathione peroxidase activity and can therefore be more efficiently protected from reactive oxygen.	Oxygen	186-192	electron transfer flavoprotein subunit alpha	Homo sapiens	44-48
25534853-11	2015	Indirect calorimetry demonstrated that whole-body oxygen consumption rates were significantly higher in IRAP(-/-) mice by 18% with mild hyperthermia.	Oxygen	50-56	leucyl/cystinyl aminopeptidase	Mus musculus	104-108
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	RB transcriptional corepressor 1	Homo sapiens	190-193
30230951-7	2018	In corroboration, after reappraising our oxygen evolution analysis, the nitration of PsbO1 proved responsible for decreased oxygen evolution from the thylakoid membranes.	Oxygen	41-47	PS II oxygen-evolving complex 1	Arabidopsis thaliana	85-90
26303471-5	2015	We will consider the role of the AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), an upstream kinase through which AMPK is intimately coupled to changes in oxygen supply via mitochondrial metabolism.	Oxygen	171-177	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	33-61
26303471-5	2015	We will consider the role of the AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), an upstream kinase through which AMPK is intimately coupled to changes in oxygen supply via mitochondrial metabolism.	Oxygen	171-177	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	63-67
26303471-5	2015	We will consider the role of the AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), an upstream kinase through which AMPK is intimately coupled to changes in oxygen supply via mitochondrial metabolism.	Oxygen	171-177	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	130-134
24273102-9	2014	CONCLUSIONS: An highly selective cyclooxygenase-2 inhibitor is an effective anti-inflammatory substitute for dexamethasone for preventing phagocyte influx into the neonatal lung during 60% O2 -mediated lung injury, and can modify the severity of that injury.	Oxygen	189-191	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	33-49
24810896-5	2014	In the present paper, we analysed the role of SUS1 and SUS4, both induced by low oxygen, in plant survival and ethanol production.	Oxygen	81-87	sucrose synthase 4	Arabidopsis thaliana	55-59
30230951-7	2018	In corroboration, after reappraising our oxygen evolution analysis, the nitration of PsbO1 proved responsible for decreased oxygen evolution from the thylakoid membranes.	Oxygen	124-130	PS II oxygen-evolving complex 1	Arabidopsis thaliana	85-90
29248531-0	2018	Tregs that express the Foxp3 transcription factor can influence oxygen-induced retinopathy.	Oxygen	64-70	forkhead box P3	Homo sapiens	23-28
25124043-3	2014	Here we investigated the molecular mechanisms underlying the oxygen-dependent expression of hASH1 in neuroblastoma cells.	Oxygen	61-67	achaete-scute family bHLH transcription factor 1	Homo sapiens	92-97
25124043-4	2014	Exposure of human neuroblastoma-derived Kelly cells to 1% O2 significantly decreased ASCL1 mRNA and hASH1 protein levels.	Oxygen	58-60	achaete-scute family bHLH transcription factor 1	Homo sapiens	85-90
25124043-4	2014	Exposure of human neuroblastoma-derived Kelly cells to 1% O2 significantly decreased ASCL1 mRNA and hASH1 protein levels.	Oxygen	58-60	achaete-scute family bHLH transcription factor 1	Homo sapiens	100-105
25205723-10	2015	This signaling pathway remarkably involves the non-mitochondrial catalytic subunit of DNA-dependent protein kinase (PRKDC), important in double-strand break repair resistance against reactive oxygen-induced genotoxic stress.	Oxygen	192-198	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	116-121
28711029-2	2017	An oxygen-independent and membrane-less glucose biobattery was prepared that consists of a dealloyed nanoporous gold (NPG) supported glucose dehydrogenase (GDH) bioanode, immobilised with the assistance of conductive polymer/Os redox polymer composites, and a solid-state NPG/MnO2 cathode.	Oxygen	3-9	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	133-154
25793203-5	2015	We highlighted the binding of carbonic anhydrase IX to nucleolar chromatin, which is regulated by oxygen levels.	Oxygen	98-104	carbonic anhydrase 9	Homo sapiens	30-51
26279426-6	2015	RESULTS: Elevated levels of IL-1beta, alphavbeta6 and TGF-beta1 were each associated with aberrant elastin production in O2-exposed lungs.	Oxygen	121-123	transforming growth factor, beta 1	Mus musculus	54-63
25010400-0	2014	Cocaine- and amphetamine-regulated transcript facilitates the neurite outgrowth in cortical neurons after oxygen and glucose deprivation through PTN-dependent pathway.	Oxygen	106-112	pleiotrophin	Mus musculus	145-148
28711029-2	2017	An oxygen-independent and membrane-less glucose biobattery was prepared that consists of a dealloyed nanoporous gold (NPG) supported glucose dehydrogenase (GDH) bioanode, immobilised with the assistance of conductive polymer/Os redox polymer composites, and a solid-state NPG/MnO2 cathode.	Oxygen	3-9	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	156-159
25400763-0	2014	Role of hypoxia-inducible factor-1alpha and survivin in oxygen-induced retinopathy in mice.	Oxygen	56-62	baculoviral IAP repeat-containing 5	Mus musculus	44-52
29042436-11	2017	However, incubation in 1% O2 in the presence of SU1498 significantly reduced Sox9 transcripts in cultured testes and increased Sox9 levels in ovaries.	Oxygen	26-28	SRY (sex determining region Y)-box 9	Mus musculus	77-81
25400763-4	2014	The model of oxygen-induced retinopathy (OIR) was induced in C57BL/6 mice by exposing 75% oxygen from postnatal day 7 (p7) to p12 and then followed by room air.	Oxygen	13-19	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	126-129
25400763-5	2014	Fluorescence angiography, immunostaining and HE staining were used to assess the visualization of retinal vascularization and the expression of HIF-1alpha and survivin protein in retina oxygen-induced retinopathy was characterized by clusters of neovascularization and regions of non-perfusion.	Oxygen	186-192	baculoviral IAP repeat-containing 5	Mus musculus	159-167
26291968-0	2015	Hb G-Waimanalo [A1] [alpha64(E13)Asp Asn; HBA1: c.193 G &gt; A] with Decreased Oxygen Affinity.	Oxygen	79-85	hemoglobin subunit alpha 1	Homo sapiens	42-46
25315652-9	2015	This MNRR1-mediated stress response may provide an important survival mechanism for cells under conditions of oxidative or hypoxic stress, both in the acute phase by altering mitochondrial oxygen utilization and in the chronic phase by promoting COX remodeling.	Oxygen	189-195	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	5-10
29042436-11	2017	However, incubation in 1% O2 in the presence of SU1498 significantly reduced Sox9 transcripts in cultured testes and increased Sox9 levels in ovaries.	Oxygen	26-28	SRY (sex determining region Y)-box 9	Mus musculus	127-131
25723575-7	2015	It is possible that the cyanobacterial HDR may independently evolve from the common ancestor of prokaryotes to obtain the NCD, which may protect the enzyme from high concentration of oxygen during photosynthesis.	Oxygen	183-189	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	Arabidopsis thaliana	39-42
26457728-2	2015	Medical professionals and students often use the mnemonic "MONA" (morphine, oxygen, nitroglycerin and aspirin) to recall treatments for ACS; however, this list of therapies is outdated.	Oxygen	76-82	GRB2 related adaptor protein 2	Homo sapiens	59-63
24878247-9	2014	Five percent O2 significantly increased the level of activated Notch1 and expression of its downstream gene, HES1.	Oxygen	13-15	hes family bHLH transcription factor 1	Homo sapiens	109-113
25044752-2	2014	The present work demonstrates that this correlation holds at the operating temperature of IT-SOFCs, 600-700  C. Solid solutions of Ce1-x Ndx O2-0.5x , Ce1-x Smx O2-0.5x , and Ce1-x Sm0.5x Nd0.5x O2-0.5x are studied.	Oxygen	141-143	carboxylesterase 1	Homo sapiens	131-134
24793962-8	2014	Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance.	Oxygen	52-58	phospholipid phosphatase 1	Mus musculus	5-8
25593505-8	2014	RESULTS: Cultured lens epithelial cells maintained in hypoxia (1% oxygen) and subsequently reintroduced into atmospheric oxygen and treated with the GSK-3beta inhibitor SB216763 illustrated a marked inhibition of phosphorylation of glycogen synthase (downstream substrate of GSK-3beta) and significant increase in nuclear translocation of beta-catenin.	Oxygen	66-72	glycogen synthase kinase 3 beta	Homo sapiens	149-158
29042436-12	2017	These findings demonstrate that both the local oxygen environment and WT1, which enhances KDR expression, contribute to sex-specific Sox9 expression in developing murine gonads.	Oxygen	47-53	kinase insert domain protein receptor	Mus musculus	90-93
25593505-8	2014	RESULTS: Cultured lens epithelial cells maintained in hypoxia (1% oxygen) and subsequently reintroduced into atmospheric oxygen and treated with the GSK-3beta inhibitor SB216763 illustrated a marked inhibition of phosphorylation of glycogen synthase (downstream substrate of GSK-3beta) and significant increase in nuclear translocation of beta-catenin.	Oxygen	121-127	glycogen synthase kinase 3 beta	Homo sapiens	149-158
25009285-3	2014	We further demonstrate that Bmi1 expression might be directly regulated by hypoxia-inducible factor-1a (HIF-1a) under low oxygen.	Oxygen	122-128	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	28-32
29042436-12	2017	These findings demonstrate that both the local oxygen environment and WT1, which enhances KDR expression, contribute to sex-specific Sox9 expression in developing murine gonads.	Oxygen	47-53	SRY (sex determining region Y)-box 9	Mus musculus	133-137
29209035-7	2017	Supplemental oxygen administration abrogated the oscillatory shear stress-induced increase in CD31+/CD41b- microparticles, and improved FMD after accounting for the shear stress stimulus.	Oxygen	13-19	platelet and endothelial cell adhesion molecule 1	Homo sapiens	94-98
25159209-9	2014	Additionally, in a rat model of oxygen-induced retinopathy, retinal endoglin was significantly increased at 14(2), 14(3), 14(4) and 14(6) compared with retinal levels in control rats.	Oxygen	32-38	endoglin	Rattus norvegicus	68-76
25531909-7	2014	The number of CD68- or CD68- and CD206-positive cells was significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury.	Oxygen	109-115	Cd68 molecule	Rattus norvegicus	14-18
25531909-7	2014	The number of CD68- or CD68- and CD206-positive cells was significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury.	Oxygen	109-115	Cd68 molecule	Rattus norvegicus	23-27
25114210-1	2014	Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient.	Oxygen	68-70	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
29032393-8	2017	Arterial oxygen saturation (87.7 +- 3.6 vs 96.9 +- 1.8% at the last sprint) and HR were lower in RSH-VHL than in RSN during most part of exercise.	Oxygen	9-15	von Hippel-Lindau tumor suppressor	Homo sapiens	97-104
25114210-1	2014	Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient.	Oxygen	68-70	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
25072999-2	2014	Titration of the carbon-centered radical, formed following the initial OH abstraction, with oxygen to give HO2 and an imine, followed by conversion of HO2 to OH by reaction with NO, resulted in biexponential OH decay traces on a millisecond time scale.	Oxygen	92-98	heme oxygenase 2	Homo sapiens	107-110
25411020-5	2014	It was found that UO2(2+) is coordinated to five carboxylate oxygen atoms from four amino acid residues of the super uranyl binding protein (SUP).	Oxygen	61-67	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	111-139
29032393-10	2017	Oxygen uptake was significantly higher in RSH-VHL than in RSN during the recovery periods following sprints at S2 (3.02 +- 0.4 vs 2.67 +- 0.5 L min-1 on average) whereas [La] was lower in RSH-VHL at the end of exercise (10.3 +- 2.9 vs 13.8 +- 3.5 mmol.L-1; p &lt; 0.01).	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	42-49
25072999-2	2014	Titration of the carbon-centered radical, formed following the initial OH abstraction, with oxygen to give HO2 and an imine, followed by conversion of HO2 to OH by reaction with NO, resulted in biexponential OH decay traces on a millisecond time scale.	Oxygen	92-98	heme oxygenase 2	Homo sapiens	151-154
25337805-1	2014	The development of cathode materials with high capacity and cycle stability is essential to emerging electric-vehicle technologies, however, of serious environmental concern is that materials with these properties developed so far contain the toxic and expensive Co. We report here the Li-rich, Co-free Li1+xMO2 (M = Li, Ni, Mn, Fe) composite cathode material, prepared via a template-free, one-step wet-chemical method followed by conventional annealing in an oxygen atmosphere.	Oxygen	461-467	transglutaminase 1	Homo sapiens	303-311
28760745-4	2017	Unlike cells adapted to a hypoxic environment (1% O2), those cultured in 5% O2 still mobilized sufficient Ca2+ to activate AMPK.	Oxygen	76-78	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	123-127
25088415-4	2014	These high oxygen levels are required for the expression of the antineuronal transcription factor Hes1 in the roof plate region.	Oxygen	11-17	hes family bHLH transcription factor 1	Homo sapiens	98-102
25088415-6	2014	High oxygen promotes a decrease in the CtBP occupancy of the promoter of Hes1.	Oxygen	5-11	hes family bHLH transcription factor 1	Homo sapiens	73-77
25622738-9	2014	After adjusting for body mass index (BMI), age and education years, MoCA scores showed negative correlations with serum TNF-alpha, AHI, oxygen reduction index (ODI) and TS90% (r = -0.266, -0.236, -0.201, -0.18 respectively, all P &lt; 0.05) and positive correlations with minimum oxygen saturation (LSaO(2)) (r = 0.224, P &lt; 0.05).	Oxygen	136-142	dedicator of cytokinesis 3	Homo sapiens	68-72
28385082-0	2017	Hyperbaric oxygen therapy modulates serum OPG/RANKL in femoral head necrosis patients.	Oxygen	11-17	TNF receptor superfamily member 11b	Homo sapiens	42-45
25622738-9	2014	After adjusting for body mass index (BMI), age and education years, MoCA scores showed negative correlations with serum TNF-alpha, AHI, oxygen reduction index (ODI) and TS90% (r = -0.266, -0.236, -0.201, -0.18 respectively, all P &lt; 0.05) and positive correlations with minimum oxygen saturation (LSaO(2)) (r = 0.224, P &lt; 0.05).	Oxygen	280-286	dedicator of cytokinesis 3	Homo sapiens	68-72
25353711-3	2014	In this work, we reported an oxidative esterification of 5-hydroxymethylfurfural (HMF) and furfural to prepare corresponding esters over Cox Oy -N@C catalysts using O2 as benign oxidant.	Oxygen	165-167	cytochrome c oxidase subunit 8A	Homo sapiens	137-140
25450464-7	2014	Also, both TRPV1 agonists induced a loss of mitochondrial membrane potential and an increase of caspase 3/7 activity and production of reactive species of oxygen and nitrogen.	Oxygen	155-161	transient receptor potential cation channel subfamily V member 1	Homo sapiens	11-16
25101962-4	2014	Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing.	Oxygen	134-140	High temperature-Induced Dauer formation	Caenorhabditis elegans	33-38
24920730-5	2014	Treatment with hypoxia (2% O2) significantly stimulated glucose uptake and GLUT1 mRNA and protein expression, but decreased GLUT8 mRNA expression in bovine MECs.	Oxygen	27-29	solute carrier family 2 member 1	Bos taurus	75-80
24920730-5	2014	Treatment with hypoxia (2% O2) significantly stimulated glucose uptake and GLUT1 mRNA and protein expression, but decreased GLUT8 mRNA expression in bovine MECs.	Oxygen	27-29	solute carrier family 2 member 8	Bos taurus	124-129
24875760-3	2014	In this work, luminescence lifetime-based sensors were used to provide accurate, extensive and non-invasive measurements of the oxygen uptake rate for human mesenchymal stem cells (hMSCs), tracheal epithelial cells (hTEpiCs) and human chondrocytes (hCCs) within a range of 2-40% O2 partial pressure.	Oxygen	128-134	copper chaperone for superoxide dismutase	Homo sapiens	249-253
29039534-3	2017	It was hypothesized that resveratrol protects HT22 cells against oxygen-glucose deprivation and re-oxygenation (OGD/R)-induced injuries through upregulation of APE1.	Oxygen	65-71	apurinic/apyrimidinic endonuclease 1	Mus musculus	160-164
25065497-8	2014	These data indicate that TRPM8-induced increase of HIF-1alpha protein in hypoxia- or normoxia-exposed prostate cancer cells was mediated through a newly characterized Ca(2+) -dependent but O2 -independent mechanism involving binding of RACK1 to HIF-1alpha and RACK1-mediated ubiquitination of HIF-1alpha.	Oxygen	189-191	transient receptor potential cation channel subfamily M member 8	Homo sapiens	25-30
28851593-7	2017	In whole-body plethysmography, hypoxia (10%O2) increased minute ventilation in both CSE+/+ and CSE-/- mice equally well, and no significant differences were found in either males or females when adjusted by body weight.	Oxygen	43-45	cystathionase (cystathionine gamma-lyase)	Mus musculus	84-87
25306099-2	2014	This study sought to investigate the effects of acute growth hormone (GH) administration on the expression of myoglobin (Mb) and Glut4 glucose transporter, two important limiting factors for O2 and glucose utilization for energy production, in cardiac muscle cells of treated rats.	Oxygen	191-193	gonadotropin releasing hormone receptor	Rattus norvegicus	54-68
25306099-2	2014	This study sought to investigate the effects of acute growth hormone (GH) administration on the expression of myoglobin (Mb) and Glut4 glucose transporter, two important limiting factors for O2 and glucose utilization for energy production, in cardiac muscle cells of treated rats.	Oxygen	191-193	myoglobin	Rattus norvegicus	110-119
25306099-2	2014	This study sought to investigate the effects of acute growth hormone (GH) administration on the expression of myoglobin (Mb) and Glut4 glucose transporter, two important limiting factors for O2 and glucose utilization for energy production, in cardiac muscle cells of treated rats.	Oxygen	191-193	myoglobin	Rattus norvegicus	121-123
28851593-7	2017	In whole-body plethysmography, hypoxia (10%O2) increased minute ventilation in both CSE+/+ and CSE-/- mice equally well, and no significant differences were found in either males or females when adjusted by body weight.	Oxygen	43-45	cystathionase (cystathionine gamma-lyase)	Mus musculus	95-98
29168506-5	2017	Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas.	Oxygen	45-51	NFS1 cysteine desulfurase	Homo sapiens	91-95
25469969-2	2014	This study determined the O2 consumption of the compPAC ventilator powered by E cylinders when ventilating the Vent Aid Training Test Lung model of high (HC) and low (LC) pulmonary compliance.	Oxygen	26-28	activation induced cytidine deaminase	Homo sapiens	116-119
29143044-4	2017	This homogeneous system exhibits a high turnover frequency (about 5 s-1) of catalyzing water oxidation to produce oxygen at eta = 720 mV.	Oxygen	114-120	endothelin receptor type A	Homo sapiens	124-127
25301889-6	2014	We further show that respiratory oxygen consumption by cod1 plantlets is exclusively associated with alternative oxidase activity and that alternative NADH dehydrogenases are also up-regulated in these plants.	Oxygen	33-39	Pentatricopeptide repeat (PPR) superfamily protein	Arabidopsis thaliana	55-59
29155844-5	2017	Corroborating oxygen-dependent regulation of MHC antigen presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7.	Oxygen	14-20	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	163-167
29155844-5	2017	Corroborating oxygen-dependent regulation of MHC antigen presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7.	Oxygen	14-20	proteasome 20S subunit beta 9	Homo sapiens	169-173
25454472-11	2014	Inhibition of placental mTORC1 signaling in response to labor may serve to down-regulate protein synthesis and amino acid transport, processes that account for a large share of placental oxygen and glucose consumption.	Oxygen	187-193	CREB regulated transcription coactivator 1	Mus musculus	24-30
29155844-5	2017	Corroborating oxygen-dependent regulation of MHC antigen presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7.	Oxygen	86-92	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	163-167
29155844-5	2017	Corroborating oxygen-dependent regulation of MHC antigen presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7.	Oxygen	86-92	proteasome 20S subunit beta 9	Homo sapiens	169-173
29185590-9	2017	Stored RBC transfusion significantly increased mixed oxygen venous saturation and arterial oxygen content.	Oxygen	53-59	RBC	Sus scrofa	7-10
25430436-10	2014	CONCLUSIONS: The present data indicate that TBP and B2M are appropriate housekeeping genes for normalization of transcript abundance measured by real-time RT-PCR in granulosa cells subjected to different plating densities, oxygen concentrations and FSH stimulation.	Oxygen	223-229	TATA-box-binding protein	Bos taurus	44-47
29185590-9	2017	Stored RBC transfusion significantly increased mixed oxygen venous saturation and arterial oxygen content.	Oxygen	91-97	RBC	Sus scrofa	7-10
29158891-5	2017	Oxygen-dependent (through pVHL, PHDs, calcium-mediated) and independent (through growth factor signaling pathway, mdm2 pathway, HSP90) regulation of HIF-1alpha leads to angiogenesis, metastasis, and cell survival.	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	26-30
25311356-5	2014	The concentration of oxygen vacancies calculated from TGA data, could reach 5.07% (atom) in this study.	Oxygen	21-27	T-box transcription factor 1	Homo sapiens	54-57
25393282-7	2014	In addition, TBL2 knockdown can lead to impaired ATF4 induction under ER stress or poor nutrient conditions such as glucose and oxygen deprivation.	Oxygen	128-134	transducin beta like 2	Homo sapiens	13-17
25116175-10	2014	As expected, PGC-1alpha mTg mice exhibited higher exercise performance, peak oxygen consumption and lower blood lactate levels following exercise, though PPARbeta/delta mKO + PGC-1alpha mTg mice showed a similar phenotype.	Oxygen	77-83	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-23
28840651-4	2017	The two lanthanide(III) ions in 1-7 are doubly bridged by two deprotonated aminophenoxide oxygen atoms of two mu2 :eta0 :eta1 :eta2 :eta1 :eta1 :eta0 -L2- ligands.	Oxygen	90-96	adaptor related protein complex 1 subunit mu 2	Homo sapiens	110-113
25077561-7	2014	Silencing of LETM1 also impaired basal mitochondrial oxygen consumption, possibly via complex IV inactivation and ATP production.	Oxygen	53-59	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	13-18
25406562-1	2014	OBJECTIVE: To study the expression of fatty acid binding protein 4 (FABP4) in lungs and bronchoalveolar lavage fluid (BALF) of preterm rats exposed to 60% O2 and to elucidate the relationship between the changes of FABP4 expression and the pathogenesis of bronchopulmonary dysplasia (BPD).	Oxygen	155-157	fatty acid binding protein 4	Rattus norvegicus	38-66
28840651-4	2017	The two lanthanide(III) ions in 1-7 are doubly bridged by two deprotonated aminophenoxide oxygen atoms of two mu2 :eta0 :eta1 :eta2 :eta1 :eta1 :eta0 -L2- ligands.	Oxygen	90-96	DNA polymerase iota	Homo sapiens	127-131
25406562-1	2014	OBJECTIVE: To study the expression of fatty acid binding protein 4 (FABP4) in lungs and bronchoalveolar lavage fluid (BALF) of preterm rats exposed to 60% O2 and to elucidate the relationship between the changes of FABP4 expression and the pathogenesis of bronchopulmonary dysplasia (BPD).	Oxygen	155-157	fatty acid binding protein 4	Rattus norvegicus	68-73
28868759-4	2017	The iron oxide nanocarbon electrocatalyst performances are highlighted by the overall overpotential of approximately 1 V needed to reach the benchmark threshold of 10 mA cm-2 for the oxygen reduction reaction and the particular activity towards oxygen evolution reaction (eta 0.4 V at 10 mA cm-2 ), comparable to that of the precious RuO2 and IrO2 catalysts.	Oxygen	183-189	endothelin receptor type A	Homo sapiens	272-275
24502504-6	2014	Also, pHBA-induced NO and H2 O2 could be compromised in NO synthesis mutants noa1, nia1 and nia2, or H2 O2 metabolism mutant rbohD/F, but suppressing NO accumulation with a NO synthesis inhibitor or using NO synthesis-related mutants did not reduce pHBA-induced H2 O2 accumulation.	Oxygen	29-31	nitrate reductase 2	Arabidopsis thaliana	92-96
28868759-4	2017	The iron oxide nanocarbon electrocatalyst performances are highlighted by the overall overpotential of approximately 1 V needed to reach the benchmark threshold of 10 mA cm-2 for the oxygen reduction reaction and the particular activity towards oxygen evolution reaction (eta 0.4 V at 10 mA cm-2 ), comparable to that of the precious RuO2 and IrO2 catalysts.	Oxygen	245-251	endothelin receptor type A	Homo sapiens	272-275
28876976-0	2017	TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death.	Oxygen	36-42	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	0-5
24712343-7	2014	A low oxygen tension reduced lubricin gene expression levels in bovine superficial chondrocytes, TGF-beta1-treated middle/deep zone chondrocytes, and TGF-beta1-treated ATDC5 cells.	Oxygen	6-12	transforming growth factor beta 1	Bos taurus	97-106
28823941-0	2017	Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia.	Oxygen	55-61	Norrie disease (pseudoglioma) (human)	Mus musculus	0-6
25268772-2	2014	Although it is known that the global transcriptional regulators FNR and ArcA are involved in oxygen response it is unclear how they interplay in the regulation of ETC enzymes under micro-aerobic chemostat conditions.	Oxygen	93-99	arginine deiminase	Escherichia coli	72-76
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	30-36	norrin cystine knot growth factor NDP	Homo sapiens	86-92
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	30-36	norrin cystine knot growth factor NDP	Homo sapiens	94-116
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	30-36	norrin cystine knot growth factor NDP	Homo sapiens	124-127
25226037-6	2014	HRA1 counteracts the induction of core low oxygen-responsive genes and transcriptional activation of hypoxia-responsive promoters by RAP2.12.	Oxygen	43-49	sequence-specific DNA binding transcription factor	Arabidopsis thaliana	0-4
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	271-277	norrin cystine knot growth factor NDP	Homo sapiens	86-92
25226037-8	2014	Comparison of the low oxygen response of tissues characterized by different levels of metabolic hypoxia (i.e., the shoot apical zone versus mature rosette leaves) revealed that the antagonistic interplay between RAP2.12 and HRA1 enables a flexible response to fluctuating hypoxia and is of importance to stress survival.	Oxygen	22-28	sequence-specific DNA binding transcription factor	Arabidopsis thaliana	224-228
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	271-277	norrin cystine knot growth factor NDP	Homo sapiens	94-116
25226037-9	2014	In Arabidopsis, an effective low oxygen-sensing response requires RAP2.12 stabilization followed by HRA1 induction to modulate the extent of the anaerobic response by negative feedback regulation of RAP2.12.	Oxygen	33-39	sequence-specific DNA binding transcription factor	Arabidopsis thaliana	100-104
28823941-1	2017	Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen.	Oxygen	271-277	norrin cystine knot growth factor NDP	Homo sapiens	124-127
28823941-4	2017	Intravitreal injections of Norrin or vehicle were done after five days of exposure to 75% oxygen from ages P7 to P12.	Oxygen	90-96	Norrie disease (pseudoglioma) (human)	Mus musculus	27-33
25225183-6	2014	We identified significant SNP associations with birth weight near coding regions for two genes involved in oxygen sensing and vascular control, PRKAA1 and EDNRA, respectively.	Oxygen	107-113	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	144-150
25225183-6	2014	We identified significant SNP associations with birth weight near coding regions for two genes involved in oxygen sensing and vascular control, PRKAA1 and EDNRA, respectively.	Oxygen	107-113	endothelin receptor type A	Homo sapiens	155-160
24992836-0	2014	Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington"s disease knock-in striatal cells.	Oxygen	129-135	insulin-like growth factor 1	Mus musculus	12-17
27900880-0	2017	Associations of nicotinamide N-methyltransferase gene single nucleotide polymorphisms with sport performance and relative maximal oxygen uptake.	Oxygen	130-136	nicotinamide N-methyltransferase	Homo sapiens	16-48
25073509-0	2014	Oxygen differentially affects the hox proteins Hoxb5 and Hoxa5 altering airway branching and lung vascular formation.	Oxygen	0-6	homeobox B5	Homo sapiens	47-52
27900880-1	2017	To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N-methyltransferase (NNMT) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ([Formula: see text]).	Oxygen	249-255	nicotinamide N-methyltransferase	Homo sapiens	112-116
28842545-5	2017	Transcriptional analysis indicated that the pdh and pox genes of L. brevis ATCC 367 were upregulated 37.92- and 18.32-fold, respectively, by oxygen and glucose exhaustion, corresponding to 5.32- and 2.35-fold increases in the respective enzyme activities.	Oxygen	141-147	pyruvate oxidase	Lactobacillus brevis ATCC 367	52-55
24996283-9	2014	Additionally, when we examined PPAR-alpha and PPARGC1A genotype distributions according to the aerobic performance test parameters, we found a statistically significant association between velocity, time and maximal oxygen consumption and PPAR-alpha and PPARGC1A genotypes (p &lt; 0.001).	Oxygen	216-222	peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Meleagris gallopavo	46-54
24996283-9	2014	Additionally, when we examined PPAR-alpha and PPARGC1A genotype distributions according to the aerobic performance test parameters, we found a statistically significant association between velocity, time and maximal oxygen consumption and PPAR-alpha and PPARGC1A genotypes (p &lt; 0.001).	Oxygen	216-222	peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Meleagris gallopavo	254-262
29085639-7	2017	Low minimum detectable change (MDC)95 values were found for heart rate (4.9 and 4.8), rate of perceived exertion (1.0 and 1.6), and cerebral oxygen response (1.2 and 0.92), during forward and backward walking, respectively.	Oxygen	141-147	C-C motif chemokine ligand 22	Homo sapiens	31-34
29123987-5	2017	We demonstrated that the introduction of JDP2 leads to upregulation of p16Ink4a and Arf and decreases cell proliferation in the presence of environmental (20% O2), but not in low (3% O2) oxygen.	Oxygen	159-161	Jun dimerization protein 2	Mus musculus	41-45
29123987-5	2017	We demonstrated that the introduction of JDP2 leads to upregulation of p16Ink4a and Arf and decreases cell proliferation in the presence of environmental (20% O2), but not in low (3% O2) oxygen.	Oxygen	183-185	Jun dimerization protein 2	Mus musculus	41-45
25161193-8	2014	IMPORTANCE: In Escherichia coli, the response regulator ArcA maintains homeostasis of redox carriers under O2-limiting conditions through a comprehensive repression of carbon oxidation pathways that require aerobic respiration to recycle redox carriers.	Oxygen	107-109	arginine deiminase	Escherichia coli	56-60
28967664-6	2017	Turn-over-frequency (TOF, i.e., O2 molecules per Ni atom per s) at eta = 350 mV revealed a continuous improvement in activity of the NiO surface with increasing Fe content, where values of 0.07 and 0.48 s-1 were measured for undoped NiO and Ni0.81Fe0.19O films, respectively.	Oxygen	32-34	endothelin receptor type A	Homo sapiens	67-70
25149138-0	2014	Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice.	Oxygen	46-52	netrin 1	Mus musculus	14-22
28698281-8	2017	Furthermore, mitochondrial respiration, as measured by oxygen consumption rate, was enhanced by miR-27b in diabetic BMPCs, with concomitant decrease of mitochondrial Bax/Bcl-2 ratio.	Oxygen	55-61	microRNA 27b	Mus musculus	96-103
25149138-1	2014	BACKGROUND: Netrin-1 has been reported to promote retinal neovascularization in oxygen-induced retinopathy (OIR).	Oxygen	80-86	netrin 1	Mus musculus	12-20
28969371-12	2017	The finding that mTORC1 activation causes an increase in oxygen consumption and renders malignant glioma cells susceptible to hypoxia and nutrient deprivation could help identify glioblastoma patient cohorts more likely to benefit from hypoxia-inducing therapies such as the VEGFA-targeting antibody bevacizumab in future clinical evaluations.	Oxygen	57-63	CREB regulated transcription coactivator 1	Mus musculus	17-23
28986453-9	2017	Conversely, cardiac overexpression of Pp2B under hypoxia was lethal, suggesting that a hypertrophic signal in the presence of insufficient oxygen supply is deleterious.	Oxygen	139-145	Calcineurin A1	Drosophila melanogaster	38-42
29031730-8	2017	Furthermore, co-activation of Ppargamma2 with either Prdm16 or Zfp423 transcripts drove distinct thermogenic gene expression patterns associated with increased or decreased oxygen consumption, respectively, mimicking typical characteristics of brite/beige or white cell lineages.	Oxygen	173-179	peroxisome proliferator activated receptor gamma	Mus musculus	30-40
28951554-0	2017	Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons.	Oxygen	71-77	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	41-46
28928465-3	2017	Adora2a expression is markedly increased in the retina of mice with oxygen-induced retinopathy (OIR).	Oxygen	68-74	adenosine A2a receptor	Mus musculus	0-7
28928465-9	2017	Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease treatment.	Oxygen	90-96	adenosine A2a receptor	Mus musculus	27-49
28912130-8	2017	Collectively these data reveal profoundly different O2 transport strategies, with the RF-s and RF-d relying proportionately more on elevated perfusive and the VL-s on diffusive O2 transport.	Oxygen	52-54	FRTS1	Homo sapiens	86-99
28912130-8	2017	Collectively these data reveal profoundly different O2 transport strategies, with the RF-s and RF-d relying proportionately more on elevated perfusive and the VL-s on diffusive O2 transport.	Oxygen	177-179	FRTS1	Homo sapiens	86-99
28825741-0	2017	Kinetics of the BrO + HO2 reaction over the temperature range T = 246-314 K. The kinetics of the reaction between gas phase BrO and HO2 radicals, BrO + HO2   HOBr + O2 (1), have been studied over the atmospherically relevant temperature range T = 246-314 K and at ambient pressure, p = 760 +- 20 Torr, using laser flash photolysis coupled with ultraviolet absorption spectroscopy.	Oxygen	23-25	heme oxygenase 2	Homo sapiens	132-135
25098716-1	2014	Myoglobin acts as an oxygen store and a reactive oxygen species acceptor in muscles.	Oxygen	21-27	myoglobin	Rattus norvegicus	0-9
28825741-0	2017	Kinetics of the BrO + HO2 reaction over the temperature range T = 246-314 K. The kinetics of the reaction between gas phase BrO and HO2 radicals, BrO + HO2   HOBr + O2 (1), have been studied over the atmospherically relevant temperature range T = 246-314 K and at ambient pressure, p = 760 +- 20 Torr, using laser flash photolysis coupled with ultraviolet absorption spectroscopy.	Oxygen	23-25	heme oxygenase 2	Homo sapiens	132-135
28825741-2	2017	Subsequently, the addition of methanol vapour to the reaction mixture, in the presence of excess oxygen, afforded the efficient simultaneous post-photolysis formation of HO2 radicals using well-defined chemistry.	Oxygen	97-103	heme oxygenase 2	Homo sapiens	170-173
24849923-2	2014	Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed neuronal death after oxygen-glucose deprivation, glutamate-induced excitotoxicity, or oxidative stress in vitro and after cerebral ischemia in vivo.	Oxygen	189-195	BH3 interacting domain death agonist	Mus musculus	121-124
24648336-5	2014	Expression levels of miR-335 were also positively correlated with donor age of hMSCs, and were increased by stimuli that induce cell senescence, such as gamma-irradiation and standard O2 concentration.	Oxygen	184-186	microRNA 335	Homo sapiens	21-28
25063194-15	2014	Oxygen supply to mitochondria in these fibres may be facilitated by an increased Mb concentration, which is regulated by an increase in Mb mRNA content per myonucleus.	Oxygen	0-6	myoglobin	Danio rerio	81-83
25063194-15	2014	Oxygen supply to mitochondria in these fibres may be facilitated by an increased Mb concentration, which is regulated by an increase in Mb mRNA content per myonucleus.	Oxygen	0-6	myoglobin	Danio rerio	136-138
28495429-2	2017	Into mitochondria, MnSOD catalyses superoxide radical producing HP and oxygen.	Oxygen	71-77	superoxide dismutase 2	Homo sapiens	19-24
24814023-0	2014	Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.	Oxygen	53-59	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	23-26
28784852-5	2017	Loss of ASIC1a was associated with a greater peak running speed (60 +- 2 vs. 53 +- 3 m min-1, P = 0.049) and peak oxygen (O2) uptake during exhaustive treadmill running (9563 +- 120 vs. 8836 +- 276 mL kg-1 h-1, n = 6-7, P = 0.0082).	Oxygen	114-120	acid-sensing (proton-gated) ion channel 1	Mus musculus	8-14
24556160-3	2014	When cholesterol was added to the detection solution, COx catalyzed the oxidation of cholesterol to generate H2O2, which could be further catalyzed by hemin to produce O2 as the coreactant in the peroxydisulfate system for signal amplification.	Oxygen	111-113	cytochrome c oxidase subunit 8A	Homo sapiens	54-57
28784852-5	2017	Loss of ASIC1a was associated with a greater peak running speed (60 +- 2 vs. 53 +- 3 m min-1, P = 0.049) and peak oxygen (O2) uptake during exhaustive treadmill running (9563 +- 120 vs. 8836 +- 276 mL kg-1 h-1, n = 6-7, P = 0.0082).	Oxygen	122-124	acid-sensing (proton-gated) ion channel 1	Mus musculus	8-14
28798696-2	2017	Three mitophagy receptors, FUNDC1, BNIP3 and NIX, induce the removal of dysfunctional mitochondria (mitophagy) under prolonged hypoxic conditions in mammalian cells, to maintain oxygen homeostasis and prevent cell death.	Oxygen	178-184	FUN14 domain containing 1	Homo sapiens	27-33
25197344-1	2014	To determine whether Hyperbaric oxygen preconditioning (HBO-PC) promotes neovascularization by increasing Stromal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in transplanted skin flaps of rats.	Oxygen	32-38	C-X-C motif chemokine ligand 12	Rattus norvegicus	106-135
25197344-1	2014	To determine whether Hyperbaric oxygen preconditioning (HBO-PC) promotes neovascularization by increasing Stromal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in transplanted skin flaps of rats.	Oxygen	32-38	C-X-C motif chemokine ligand 12	Rattus norvegicus	137-142
28798696-2	2017	Three mitophagy receptors, FUNDC1, BNIP3 and NIX, induce the removal of dysfunctional mitochondria (mitophagy) under prolonged hypoxic conditions in mammalian cells, to maintain oxygen homeostasis and prevent cell death.	Oxygen	178-184	BCL2 interacting protein 3 like	Homo sapiens	45-48
28798696-9	2017	Molecular evolutionary analysis revealed that BNIP3 and NIX, as the targets of oxygen sensing HIF-1alpha, showed higher rates of substitution in fishes than in mammals.	Oxygen	79-85	BCL2 interacting protein 3 like	Homo sapiens	56-59
28733640-3	2017	We further show that TGF-beta and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy.	Oxygen	144-150	transforming growth factor, beta 1	Mus musculus	21-29
25025207-8	2014	The EWS patients are likely to be complicated by EWS-FLI fusion and deficiency in various signaling pathways, including Wnt, Fas/Rho and intracellular oxygen.	Oxygen	151-157	EWS RNA binding protein 1	Homo sapiens	4-7
24901940-3	2014	The results of this long-term permeation operation revealed a stepwise increase in oxygen permeation values at 1000  C after each thermal cycle, reaching from 1.38 cm(3) (STP) min(-1) cm(-2) in the first cycle to 1.75 cm(3) (STP) min(-1) cm(-2) in the fourth cycle.	Oxygen	83-89	sulfotransferase family 1A member 1	Homo sapiens	171-174
24901940-3	2014	The results of this long-term permeation operation revealed a stepwise increase in oxygen permeation values at 1000  C after each thermal cycle, reaching from 1.38 cm(3) (STP) min(-1) cm(-2) in the first cycle to 1.75 cm(3) (STP) min(-1) cm(-2) in the fourth cycle.	Oxygen	83-89	sulfotransferase family 1A member 1	Homo sapiens	225-228
28724407-6	2017	Structural analyses of the X. dendrorhous P450 proteins showed that all of them have a predicted transmembrane region at their N-terminus and have the conserved domains characteristic of the P450s, including the heme-binding region (FxxGxRxCxG); the PER domain, with the characteristic signature for fungi (PxRW); the ExxR motif in the K-helix region and the oxygen-binding domain (OBD) (AGxDTT); also, the characteristic secondary structure elements of all the P450 proteins were identified.	Oxygen	359-365	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	42-46
24901940-5	2014	Despite a partial decrease in oxygen permeation fluxes at 850  C, a steady state of 0.25 cm(3) (STP) min(-1) cm(-2) was reached and maintained for more than 100 h. The newly developed PSCF membrane also exhibited a higher oxygen permeation flux with He and CO2 sweeping at all measured temperatures compared to a similar La0.6Sr0.4Co0.8Fe0.2O3-delta (LSCF) membrane.	Oxygen	30-36	sulfotransferase family 1A member 1	Homo sapiens	96-99
24901940-5	2014	Despite a partial decrease in oxygen permeation fluxes at 850  C, a steady state of 0.25 cm(3) (STP) min(-1) cm(-2) was reached and maintained for more than 100 h. The newly developed PSCF membrane also exhibited a higher oxygen permeation flux with He and CO2 sweeping at all measured temperatures compared to a similar La0.6Sr0.4Co0.8Fe0.2O3-delta (LSCF) membrane.	Oxygen	222-228	sulfotransferase family 1A member 1	Homo sapiens	96-99
28704502-0	2017	Brain natriuretic peptide (BNP) may play a major role in risk stratification based on cerebral oxygen saturation by near-infrared spectroscopy in patients undergoing major cardiovascular surgery.	Oxygen	95-101	natriuretic peptide B	Homo sapiens	27-30
24589481-10	2014	CONCLUSION: Disruption of NRG1-ErbB4 signaling in the parvalbumin-positive interneurons might, at least partially, contribute to the isoflurane-induced hippocampus-dependent cognitive impairment after exposure to isoflurane carried by 100% O2 in aged mice.	Oxygen	240-242	neuregulin 1	Mus musculus	26-30
29137374-5	2017	In in vitro models of mouse embryonic stem cell-derived cardiomyocytes, we showed that hypoxia (1% O2) or the pharmacological stabilization of HIFs significantly increased MHCbeta (Myh7) gene expression.	Oxygen	99-101	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	181-185
27371805-8	2017	In terms of cellular oxygen consumption, both CNTs when coexposed with STX antagonize the toxin effect.	Oxygen	21-27	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Mus musculus	71-74
24687991-10	2014	Moreover, SIRT5 overexpression increased ATP synthesis and oxygen consumption in HepG2 cells, but did not affect mitochondrial biogenesis.	Oxygen	59-65	sirtuin 5	Homo sapiens	10-15
24790087-13	2014	Specifically, BKCa channel agonists like NS1619 maintain DA patency even in the presence of O2 and may be clinically useful.	Oxygen	92-94	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	14-18
24974917-8	2014	Concomitantly, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen.	Oxygen	89-95	activity regulated cytoskeleton associated protein	Homo sapiens	63-68
28623968-8	2017	The effect was exacerbated by culture at atmospheric oxygen concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, protein metabolism; apoptosis, inflammatory responses; and diminished trophoblast proliferation, differentiation, invasion, regeneration, and viability.	Oxygen	53-59	homeobox A9	Homo sapiens	135-140
24642455-2	2014	One potential neuroprotective mechanism is to increase oxygen binding proteins such as neuroglobin.	Oxygen	55-61	neuroglobin	Mus musculus	87-98
24642455-3	2014	Neuroglobin has a high affinity for oxygen, is an effective free radical scavenger, and is neuroprotective within the brain following hypoxia and ischemia.	Oxygen	36-42	neuroglobin	Mus musculus	0-11
24917593-4	2014	Memo was also required for the sustained production of the ROS O2- by NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 1 (NOX1) in breast cancer cells.	Oxygen	63-65	mediator of cell motility 1	Homo sapiens	0-4
24917593-4	2014	Memo was also required for the sustained production of the ROS O2- by NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 1 (NOX1) in breast cancer cells.	Oxygen	63-65	NADPH oxidase 1	Homo sapiens	149-153
25071412-5	2014	Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species.	Oxygen	189-195	superoxide dismutase 2	Homo sapiens	0-30
25071412-5	2014	Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species.	Oxygen	189-195	superoxide dismutase 2	Homo sapiens	32-37
28623968-8	2017	The effect was exacerbated by culture at atmospheric oxygen concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, protein metabolism; apoptosis, inflammatory responses; and diminished trophoblast proliferation, differentiation, invasion, regeneration, and viability.	Oxygen	53-59	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-177
28730075-0	2017	CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	85-91	mitogen-activated protein kinase 3	Mus musculus	7-13
24561181-2	2014	Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O2 consumed as H2O2 upon addition of NADPH.	Oxygen	78-80	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	6-21
24787897-5	2014	PSD-93 deletion also reduced cultured cortical neuronal death caused by glucose and oxygen deprivation (OGD).	Oxygen	84-90	discs large MAGUK scaffold protein 2	Mus musculus	0-6
28730075-1	2017	AIM: To investigate the role of CCR7/p-ERK1/2/VEGF signaling in the mouse model of oxygen-induced retinopathy (OIR).	Oxygen	83-89	mitogen-activated protein kinase 3	Mus musculus	39-45
25176209-8	2014	A significant association of GLUT4 SNP rs5417 allele carried in control subjects, compared with moderate and severe hypoxia in OSAS patients (P&lt;0.05); AA+AC genotype relative to CC with low oxygen levels in subjects significantly reduced.	Oxygen	193-199	solute carrier family 2 member 4	Homo sapiens	29-34
28512249-6	2017	p62 attenuation altered mitochondrial morphology, reduced mitochondrial membrane polarization and maximal respiration, and increased mitochondrial reactive oxygen species and mitophagy marker PINK1.	Oxygen	156-162	sequestosome 1	Mus musculus	0-3
24879052-6	2014	We found that levels of miR-17-5p and arginase II were significantly greater in cultured hPASMC exposed to 1% O2 for 48 h than in hPASMC exposed to 21% O2 for 48 h. Furthermore, inhibiting miR-17-5p expression decreased hypoxia-induced arginase II protein levels in hPASMC.	Oxygen	110-112	microRNA 17	Homo sapiens	24-33
24879052-6	2014	We found that levels of miR-17-5p and arginase II were significantly greater in cultured hPASMC exposed to 1% O2 for 48 h than in hPASMC exposed to 21% O2 for 48 h. Furthermore, inhibiting miR-17-5p expression decreased hypoxia-induced arginase II protein levels in hPASMC.	Oxygen	110-112	microRNA 17	Homo sapiens	189-198
24879052-6	2014	We found that levels of miR-17-5p and arginase II were significantly greater in cultured hPASMC exposed to 1% O2 for 48 h than in hPASMC exposed to 21% O2 for 48 h. Furthermore, inhibiting miR-17-5p expression decreased hypoxia-induced arginase II protein levels in hPASMC.	Oxygen	152-154	microRNA 17	Homo sapiens	24-33
24730682-6	2014	RESULTS: Cortical mitochondria from Ngb transgene, better maintained ATP synthesis-linked oxygen consumption and unlike wild type mitochondria did not increase futile oxygen consumption feeding the proton leak, reflecting lesser smoke-induced mitochondrial compromise.	Oxygen	90-96	neuroglobin	Mus musculus	36-39
24754561-2	2014	In this system, H( ) (or HO2( ) in the presence of dissolved oxygen) and H2O2 produced by the radiolytic decomposition of water both reduce Ce(4+) ions to Ce(3+) ions, while ( )OH radicals oxidize the Ce(3+) present in the solution back to Ce(4+).	Oxygen	61-67	heme oxygenase 2	Homo sapiens	25-28
24405386-0	2014	Human adipose-derived stromal/stem cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture conditions.	Oxygen	110-116	interleukin 2 receptor subunit alpha	Homo sapiens	63-67
28589937-3	2017	The loss of CHCHD2 in Drosophila causes abnormal matrix structures and impaired oxygen respiration in mitochondria, leading to oxidative stress, dopaminergic neuron loss and motor dysfunction with age.	Oxygen	80-86	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	12-18
24405386-0	2014	Human adipose-derived stromal/stem cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture conditions.	Oxygen	110-116	forkhead box P3	Homo sapiens	68-73
24405386-3	2014	In this study, we show that ASCs stimulated proliferation of naive CD4(+) T cells and the percentage of CD25(+) T cells was significantly increased under both low and ambient O2.	Oxygen	175-177	interleukin 2 receptor subunit alpha	Homo sapiens	104-108
24405386-4	2014	Forkhead box P3 (FoxP3) and transforming growth factor beta (TGF-beta) mRNA expression were significantly increased when ASCs were cocultured with CD4(+) T cells under low compared with ambient O2 conditions.	Oxygen	194-196	forkhead box P3	Homo sapiens	0-15
24405386-4	2014	Forkhead box P3 (FoxP3) and transforming growth factor beta (TGF-beta) mRNA expression were significantly increased when ASCs were cocultured with CD4(+) T cells under low compared with ambient O2 conditions.	Oxygen	194-196	forkhead box P3	Homo sapiens	17-22
24405386-5	2014	The low O2-induced regulatory T cells (iTregs) exhibited functionality when added to mixed lymphocyte reactions as demonstrated by inhibition of peripheral blood mononuclear cell proliferation, and by &gt;300-fold increase in FoxP3 mRNA, and &gt;2-fold increase in TGF-beta mRNA expression.	Oxygen	8-10	forkhead box P3	Homo sapiens	226-231
24446190-4	2014	Optical spectroscopy and oxymetry enabled to estimate an O2-sensitive heme-containing protein content of approximately 180 ng globin per 10(6) HSPC and a P50 of approximately 3 microM O2.	Oxygen	57-59	proteasome 20S subunit alpha 7	Homo sapiens	143-147
24713088-6	2014	In the PheH reaction, the transient formation of the 4a-hydroxypterin product was readily detected; tandem mass spectrometry confirmed attachment of the oxygen to C(4a).	Oxygen	153-159	phenylalanine hydroxylase	Homo sapiens	7-11
24833782-9	2014	The ratio of muscle force to Pmv(O2) was higher for the duration of tetanic contractions in PGC-1alpha mice.	Oxygen	33-35	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	92-102
24833782-11	2014	Moreover, overexpression of PGC-1alpha may accelerate O2 utilization kinetics to a greater extent than O2 delivery kinetics.	Oxygen	54-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	28-38
24585023-9	2014	Computation of relevant stationary points on the potential energy surfaces for the reactions of Rp and Rs with O2 indicates this cyclic ether is formed via a resonance-stabilized hydroperoxyalkyl radical (QOOH) intermediate, formed from isomerization of the RpO2 radical.	Oxygen	111-113	RNA polymerase II subunit A	Homo sapiens	258-262
25057335-0	2014	The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.	Oxygen	96-102	citrate synthase	Homo sapiens	55-71
25057335-3	2014	However, this relationship and absolute values of CS and maximal oxygen uptake (V.O2max) has never been assessed across different studies.	Oxygen	65-71	citrate synthase	Homo sapiens	50-52
28232454-11	2017	Mitochondrial oxygen flux rates of FF mice diet were uniformly lower with all the tested substrates (13-276 pmol s-1 ml-1 per unit citrate synthase) than SC mice (17-394 pmol s-1 ml-1 per unit citrate synthase) and was accompanied by decreased mitochondrial:nuclear gene copy number ratios after 4 wk.	Oxygen	14-20	citrate synthase	Mus musculus	131-147
24849810-0	2014	Gene expression analysis reveals inhibition of radiation-induced TGFbeta-signaling by hyperbaric oxygen therapy in mouse salivary glands.	Oxygen	97-103	transforming growth factor, beta 1	Mus musculus	65-72
24333723-5	2014	Among them, HIF-1alpha is known to be the master regulator of cellular oxygen homeostasis, mediating transcriptional activation of lymphangiogenesis via regulation of signaling cascades like VEGF-A/-C/-D, TGF-beta and Prox-1 in experimental and human tumors.	Oxygen	71-77	prospero homeobox 1	Homo sapiens	218-224
24610812-9	2014	An important effect of calmodulin binding is to suppress adventitious electron transfer from nNOS to molecular oxygen and thereby preventing accumulation of reactive oxygen species.	Oxygen	111-117	nitric oxide synthase 1	Homo sapiens	93-97
27731907-1	2017	PURPOSE: Capillary transit time heterogeneity, measured as CTH, may set the upper limit for extraction of substances in brain tissue, e.g., oxygen.	Oxygen	140-146	V-set and immunoglobulin domain containing 2	Homo sapiens	59-62
24763195-3	2014	When E. coli encounters environments with different O2 availabilities, the expression of the genes encoding the alternative terminal oxidases, the cydAB and cyoABCDE operons, are regulated by two O2-responsive transcription factors, ArcA (an indirect O2 sensor) and FNR (a direct O2 sensor).	Oxygen	52-54	arginine deiminase	Escherichia coli	233-237
25161348-2	2014	However, there is no experimental study elucidating the relationship between cardiac eNOS expression and elevated plasma viscosity in low oxygen delivery pathological conditions such as hemorrhagic shock-resuscitation and hemodilution.	Oxygen	138-144	nitric oxide synthase, endothelial	Mesocricetus auratus	85-89
24670382-7	2014	By contrast, a modification of other parameters (intracellular O2- content, Tnap activity, and Bmp2 upregulation) can be observed in Abcc6(-/-) mice after the onset of tissue mineralization.	Oxygen	63-65	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	133-138
24763195-3	2014	When E. coli encounters environments with different O2 availabilities, the expression of the genes encoding the alternative terminal oxidases, the cydAB and cyoABCDE operons, are regulated by two O2-responsive transcription factors, ArcA (an indirect O2 sensor) and FNR (a direct O2 sensor).	Oxygen	196-198	arginine deiminase	Escherichia coli	233-237
27829319-5	2017	OBJECTIVE: Evaluation of Sig1R, SOD1, and SOD2 expression in different concentrations of oxygen (1%, 10%, 21%) in colon adenocarcinoma cell lines.	Oxygen	89-95	superoxide dismutase 2	Homo sapiens	42-46
24763195-3	2014	When E. coli encounters environments with different O2 availabilities, the expression of the genes encoding the alternative terminal oxidases, the cydAB and cyoABCDE operons, are regulated by two O2-responsive transcription factors, ArcA (an indirect O2 sensor) and FNR (a direct O2 sensor).	Oxygen	196-198	arginine deiminase	Escherichia coli	233-237
24763195-4	2014	It has been suggested that O2-consumption by the terminal oxidases located at the cytoplasmic membrane significantly affects the activities of ArcA and FNR in the bacterial nucleoid.	Oxygen	27-29	arginine deiminase	Escherichia coli	143-147
24763195-5	2014	In this study, an agent-based modeling approach has been taken to spatially simulate the uptake and consumption of O2 by E. coli and the consequent modulation of ArcA and FNR activities based on experimental data obtained from highly controlled chemostat cultures.	Oxygen	115-117	arginine deiminase	Escherichia coli	162-166
24914613-2	2014	In an effort to reduce the number of layers required to achieve a very low oxygen transmission rate (OTR (&lt;0.01 cc/m(2) day atm)) in these nanocoatings, buffered cationic chitosan (CH) and vermiculite clay (VMT) were deposited using layer-by-layer (LbL) assembly.	Oxygen	75-81	oxytocin receptor	Homo sapiens	101-104
27829319-10	2017	RESULTS: We observed significant changes in expression of Sig1R, SOD1, SOD2 due to different oxygen concentrations.	Oxygen	93-99	superoxide dismutase 2	Homo sapiens	71-75
28585439-7	2017	Moreover, association analysis indicated that the Tibetan version of GCH1 was significantly associated with multiple physiological traits in Tibetans, including blood nitric oxide concentration, blood oxygen saturation, and hemoglobin concentration.	Oxygen	201-207	GTP cyclohydrolase 1	Homo sapiens	69-73
24960187-5	2014	Our results suggest that sympathomimetic agents combined with endothelin-A receptor blockers offset altitude-induced fatigue in rats by synergistically increasing the delivery rate of oxygen to hypoxic muscle by concomitantly augmenting perfusion pressure and improving capillary conductance in the skeletal muscle.	Oxygen	184-190	endothelin receptor type A	Rattus norvegicus	62-83
24840065-11	2014	The rates of electron transfer from ferrocytochrome c to heme a and the kinetics of the oxidation of the fully reduced CcO with O2 were not affected in the peroxide-modified CcO.	Oxygen	128-130	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	119-122
24661879-0	2014	USF-1 inhibition protects against oxygen-and-glucose-deprivation-induced apoptosis via the downregulation of miR-132 in HepG2 cells.	Oxygen	34-40	microRNA 132	Homo sapiens	109-116
24584511-0	2014	Heme bound amylin self-assembled monolayers on an Au electrode: an efficient bio-electrode for O2 reduction to H2O.	Oxygen	95-97	islet amyloid polypeptide	Homo sapiens	11-17
24584511-1	2014	Self-assembled monolayers of the water soluble hydrophilic part of naturally occurring amylin and its Arg11 mutant have been assembled on an Au surface, which are found to efficiently catalyze selective 4e(-)/4H(+) O2 reduction reaction (ORR) upon binding heme with a kcat of ~10(7) M(-1) s(-1) under ambient conditions, where the Arg11 residue plays the key role of proton transfer in determining the rate of ORR.	Oxygen	215-217	islet amyloid polypeptide	Homo sapiens	87-93
24651728-4	2014	Using the results of formation energy calculations in the presence of oxygen vacancies and Cr atom substitution at the Ti sites, we demonstrate that the Cr3+ state is a source of Curie-Weiss-type magnetic response, whereas the Cr4+ defect states contribute to the ferromagnetic component.	Oxygen	70-76	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	153-156
24512724-0	2014	Hyperbaric oxygen enlarges the area of brain damage in MCAO rats by blocking autophagy via ERK1/2 activation.	Oxygen	11-17	mitogen activated protein kinase 3	Rattus norvegicus	91-97
24908009-5	2014	Time resolved HO2 profiles under very low O2 concentrations suggest that another unknown HO2 forming reaction path exists in this reaction system besides the conversion of HCO radicals and H atoms by reaction with O2.	Oxygen	15-17	heme oxygenase 2	Homo sapiens	89-92
24908009-5	2014	Time resolved HO2 profiles under very low O2 concentrations suggest that another unknown HO2 forming reaction path exists in this reaction system besides the conversion of HCO radicals and H atoms by reaction with O2.	Oxygen	42-44	heme oxygenase 2	Homo sapiens	14-17
24908009-5	2014	Time resolved HO2 profiles under very low O2 concentrations suggest that another unknown HO2 forming reaction path exists in this reaction system besides the conversion of HCO radicals and H atoms by reaction with O2.	Oxygen	42-44	heme oxygenase 2	Homo sapiens	89-92
28339085-7	2017	Firstly, activation of MUC4 induces nuclear translocation of beta-catenin and promotes the process of angiogenesis that provides necessary nutrition or oxygen for cancer cells.	Oxygen	152-158	mucin 4, cell surface associated	Homo sapiens	23-27
24894399-2	2014	The aim of this study was to assess whether blockade of the renin-angiotensin system ameliorated these effects in rats with oxygen induced retinopathy (OIR).	Oxygen	124-130	renin	Rattus norvegicus	60-65
24754211-3	2014	METHODS: Ernsting proposed that prolonged exposure to alveolar O2 pressures less than 30 mmHg (P30) causes neurological damage.	Oxygen	63-65	centromere protein V	Homo sapiens	95-98
28508041-14	2017	Together, our data show that TDP1 resolves mtPDBs, thereby regulating mitochondrial gene transcription and oxygen consumption by oxidative phosphorylation, thus conferring cellular protection against reactive oxygen species-induced damage.	Oxygen	107-113	tyrosyl-DNA phosphodiesterase 1	Mus musculus	29-33
24356583-1	2014	The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely  OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water).	Oxygen	269-271	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
24799395-6	2014	Bond Critical Points (BCP) information between the minor groove of the DNA and the metallopeptides shows an increase in electronic density between Gly(1) , the His residues, and the oxygen atoms of the thymine nucleotide.	Oxygen	182-188	threonine aldolase 1, pseudogene	Homo sapiens	147-153
24152213-5	2014	COPD-related worries of becoming short of breath (SOB), needing to use inhalers, or oxygen level becoming low were endorsed by 31, 14, and 12 subjects, respectively.	Oxygen	84-90	COPD	Homo sapiens	0-4
24375083-6	2014	RESULTS: In total, ~81% of the gene expression changes were altered in response to reoxygenation with 60 or 100% O2 and constituted many inflammatory-responsive genes (i.e., C5ar2, Stat3, and Ccl12).	Oxygen	113-115	complement component 5a receptor 2	Mus musculus	174-179
28330905-8	2017	Furthermore, anti-Scg3 prevented retinal neovascularization in oxygen-induced retinopathy mice, a surrogate model for retinopathy of prematurity (ROP).	Oxygen	63-69	secretogranin III	Mus musculus	18-22
24551877-0	2014	Post modification of MOF derived carbon via g-C3N4 entrapment for an efficient metal-free oxygen reduction reaction.	Oxygen	90-96	lysine acetyltransferase 8	Homo sapiens	21-24
24617525-7	2014	Although the body weight was surprisingly decreased by IGF-1 transgenic expression, significantly higher oxygen consumption rates were measured in IGF-1-overexpressing transgenic fish compared with their nontransgenic control fish.	Oxygen	105-111	insulin-like growth factor 1	Danio rerio	147-152
28351984-2	2017	The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits.	Oxygen	29-35	cytochrome b-245, beta polypeptide	Mus musculus	92-100
28346371-1	2017	Two transient receptor potential (TRP) channels-TRPA1 and TRPV3-are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity.	Oxygen	116-122	transient receptor potential cation channel subfamily A member 1	Homo sapiens	48-53
24682380-2	2014	The aim of this study was to determine whether PGC-1alpha is involved in the transcriptional regulation of retinal neovascularization in oxygen-induced retinopathy (OIR).	Oxygen	137-143	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	47-57
24627160-0	2014	Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.	Oxygen	0-6	Ras homolog, mTORC1 binding	Homo sapiens	61-65
24627160-3	2014	This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells.	Oxygen	133-139	Ras homolog, mTORC1 binding	Homo sapiens	41-45
24469456-5	2014	In vivo drim2 homozygous knock-out was lethal at the larval stage, preceded by the following: (i) impaired locomotor behavior; (ii) decreased rates of oxygen consumption, and (iii) depletion of mtDNA.	Oxygen	151-157	Replication in mitochondria 2	Drosophila melanogaster	8-13
24375723-4	2014	Here we demonstrate that reducing oxygen concentration from 21% to either 1 or 0% restored in a concentration-dependent manner the expression of MCT4 at the mRNA and protein levels in cultured astrocytes.	Oxygen	34-40	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	145-149
24627160-3	2014	This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells.	Oxygen	133-139	Ras homolog, mTORC1 binding	Homo sapiens	96-100
24375723-6	2014	MCT4 expression was shown to be controlled by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) since under low oxygen levels, transfecting astrocyte cultures with a siRNA targeting HIF-1alpha largely prevented MCT4 induction.	Oxygen	132-138	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	0-4
28082094-9	2017	CONCLUSION: Acute 40% oxygen supplementation in patients with Eisenmenger syndrome led to an improvement in 6MWT distance, faster HRR1 and lower dyspnea and lower limb fatigue perception.	Oxygen	22-28	nuclear receptor subfamily 1 group H member 4	Homo sapiens	130-134
24375723-7	2014	Moreover, the prolyl hydroxylase inhibitor dimethyloxalylglycine (DMOG) induced MCT4 expression in astrocytes cultured in presence of 21% oxygen.	Oxygen	138-144	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	80-84
24375723-8	2014	In parallel, glycolytic activity was enhanced by exposure to 1% oxygen as demonstrated by the increased lactate release, an effect dependent on MCT4 expression.	Oxygen	64-70	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	144-148
24375723-9	2014	Finally, MCT4 expression was found to be necessary for astrocyte survival when exposed for a prolonged period to 1% oxygen.	Oxygen	116-122	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	9-13
24375723-10	2014	These data suggest that a major determinant of astrocyte MCT4 expression in vivo is likely the oxygen tension.	Oxygen	95-101	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	57-61
24411201-4	2014	These structure-activity relationships are consistent with an X-ray structure of a representative compound bound in the AKR1C3 active site, which showed H-bonding between the carbonyl oxygen of the drug and Tyr55 and His117 in the "oxyanion hole" of the enzyme, with the piperazine bridging unit providing the correct twist to allow the terminal benzene ring to occupy the lipophilic pocket and align with Phe311.	Oxygen	184-190	aldo-keto reductase family 1 member C3	Homo sapiens	120-126
24327174-7	2014	Repeated exercise in hypoxia promoted the biogenesis of subsarcolemmal mitochondria and this was co-related to expression of isoform 2 of COX-4 with higher oxygen affinity after single exercise, de-oxygenation time and myoglobin content (r &gt;= 0.75).	Oxygen	156-162	cytochrome c oxidase subunit 4I1	Homo sapiens	138-143
24553846-2	2014	At 20% O2, the photochemical quantum yield of PSII decreased, in particular in the pgr5 plants, soon after the start of the fluctuating light treatment.	Oxygen	7-9	proton gradient regulation 5	Arabidopsis thaliana	83-87
24553846-7	2014	In contrast to the wild type, the ratio of the PSI to the PSII ETR in pgr5 was higher in LL but lower in HL at 20% O2 due to PSI acceptor-side limitation.	Oxygen	115-117	proton gradient regulation 5	Arabidopsis thaliana	70-74
24553846-8	2014	At 2.7% or 0% O2, the CEF-PSI of the pgr5 plants was enhanced, the acceptor-side limitation of PSI electron flow was released and PSI photoinhibition was not observed.	Oxygen	14-16	proton gradient regulation 5	Arabidopsis thaliana	37-41
24320879-9	2014	The eye field development markers Pax6, Sox2, and Otx2 are present in hRPCs up to passage 16 in 3% O2 .	Oxygen	99-101	paired box 6	Homo sapiens	34-38
24460692-7	2014	However, physical removal of dissolved oxygen prior to RF-PRT protects ADAMTS13 as well as FVIII and fibrinogen from damage, indicating a direct role for reactive oxygen species.	Oxygen	39-45	coagulation factor VIII	Homo sapiens	91-96
27916644-4	2017	Similar to the action of chemical mitochondrial uncouplers, UCP1 protein dissipates the proton gradient across the inner mitochondrial membrane, thus allowing maximum activity of the respiratory chain and compensatory increase in oxygen consumption, uncoupled from ATP synthesis.	Oxygen	230-236	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	60-64
24643582-1	2014	Heterostructured ZnO/SnO(2-x) nanoparticles (NPs) were synthesized by a facile two-step hydrothermal process for the first time and exhibited excellent photocatalytic activity due to increased oxygen vacancies and matched band edge alignment.	Oxygen	193-199	strawberry notch homolog 1	Homo sapiens	21-24
24327658-2	2014	In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis.	Oxygen	40-46	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	18-23
24327658-2	2014	In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis.	Oxygen	98-104	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	18-23
24327658-2	2014	In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis.	Oxygen	98-104	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	18-23
24327658-3	2014	Low oxygen stimulates proteolytic cleavage of the SREBP homolog Sre1, generating the active transcription factor Sre1N that drives expression of sterol biosynthetic enzymes.	Oxygen	4-10	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	50-55
24448514-3	2014	In particular, the ternary Au@Ag2S-Pt nanocomposites display superior methanol oxidation reaction (MOR) selectivity due to the electronic coupling effect among different domains of the nanocomposites, while the cage-bell structured Pt-Ru nanoparticles exhibit excellent methanol tolerance for oxygen reduction reaction (ORR) at the cathode because of the differential diffusion of methanol and oxygen in the porous Ru shell of the cage-bell nanoparticles.	Oxygen	293-299	angiotensin II receptor type 1	Homo sapiens	30-34
24777200-8	2014	Further experiments on oxygen-induced retinopathy (OIR) in mice revealed that eye drops containing large amounts of miR-410 efficiently downregulate VEGFA expression, prevent retinal angiogenesis and effectively treat RNV.	Oxygen	23-29	microRNA 410	Mus musculus	116-123
27738746-8	2017	In brown adipocytes of HIF-1alpha++ mice, oxygen consumption decreased ~50 % in association with reduced mitochondrial content, uncoupling protein 2, and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1alpha).	Oxygen	42-48	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	218-228
24465728-0	2014	Inhibition of oxygen-induced ischemic retinal neovascularization with adenoviral 15-lipoxygenase-1 gene transfer via up-regulation of PPAR-gamma and down-regulation of VEGFR-2 expression.	Oxygen	14-20	peroxisome proliferator activated receptor gamma	Mus musculus	134-144
24465728-0	2014	Inhibition of oxygen-induced ischemic retinal neovascularization with adenoviral 15-lipoxygenase-1 gene transfer via up-regulation of PPAR-gamma and down-regulation of VEGFR-2 expression.	Oxygen	14-20	kinase insert domain protein receptor	Mus musculus	168-175
24743740-9	2014	Targeted Met activation was successful also in the setting of low oxygen conditions, in which Met agonist antibodies or HGF demonstrated anti-apoptotic and anti-autophagic effects.	Oxygen	66-72	hepatocyte growth factor	Homo sapiens	120-123
28049732-4	2017	An increase in mitochondrial oxygen consumption and reserve capacity was observed in murine and human lung fibroblasts with genetic deficiency (or silencing) of Nox4.	Oxygen	29-35	NADPH oxidase 4	Homo sapiens	161-165
24743169-9	2014	By immunofluorescence we observed an increase in MMP-2 and TIMP-1 staining in aortas of oxygen-exposed rats whereas TIMP-2 staining was reduced, indicating a shift in the balance towards degradation of the extra-cellular matrix and increased deposition of collagen.	Oxygen	88-94	matrix metallopeptidase 2	Rattus norvegicus	49-54
24465590-2	2014	Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive".	Oxygen	217-223	serine dehydratase	Mus musculus	53-56
27906706-10	2017	After weaning from cardiopulmonary bypass, renal oxygenation was further impaired due to hemodilution and an increase in renal oxygen consumption, accompanied by a seven-fold increase in the urinary N-acetyl-beta-D-glucosaminidase/creatinine ratio.	Oxygen	49-55	O-GlcNAcase	Homo sapiens	199-230
25015806-5	2014	Pregnancy requires highly developed cell-to-cell coupling, which is affected partly through the formation of intercellular GJs by Cx43, a gap junction protein, within adjacent cell membranes to help facilitate the increase of uterine blood flow (UBF) in order to ensure adequate perfusion for nutrient and oxygen delivery to the placenta and thus the fetus.	Oxygen	306-312	gap junction protein alpha 1	Homo sapiens	130-134
24077878-8	2014	In vitro studies indicated that the up-regulation of VPS4B may be involved in oxygen-glucose deprivation-induced PC12 cell death.	Oxygen	78-84	vacuolar protein sorting 4 homolog B	Rattus norvegicus	53-58
23859619-6	2014	Although AMPK activation inhibits tumor growth by targeting multiple signaling pathways relevant to tumorigenesis, under certain cellular contexts or certain stages of tumor development, AMPK might act as a protective response to metabolic stresses, such as nutrient deprivation, low oxygen, and low pH, or as downstream effectors of oncogenic proteins, including androgen receptor, hypoxia-inducible factor-1alpha, c-Src, and MYC.	Oxygen	284-290	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	9-13
23859619-6	2014	Although AMPK activation inhibits tumor growth by targeting multiple signaling pathways relevant to tumorigenesis, under certain cellular contexts or certain stages of tumor development, AMPK might act as a protective response to metabolic stresses, such as nutrient deprivation, low oxygen, and low pH, or as downstream effectors of oncogenic proteins, including androgen receptor, hypoxia-inducible factor-1alpha, c-Src, and MYC.	Oxygen	284-290	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	187-191
24717514-12	2014	NNMT inhibition in adipocytes increases oxygen consumption in an ODC-, SSAT- and PAO-dependent manner.	Oxygen	40-46	spermidine/spermine N1-acetyl transferase 1	Mus musculus	71-75
24529326-0	2014	Neuroprotective effects of neuregulin-1 ss on oligodendrocyte type 2 astrocyte progenitors following oxygen and glucose deprivation.	Oxygen	101-107	neuregulin 1	Homo sapiens	27-39
24782664-6	2014	PID controller is presented to control flow of hydrogen and oxygen to FC and improve transient and steady state responses of the output voltage to load disturbances.	Oxygen	60-66	metastasis associated 1 family member 2	Homo sapiens	0-3
27376865-6	2017	Linear relationships between flow distributions and tissue oxygen extraction calculated from [Formula: see text] were found between the left common carotid versus cerebral tissue [Formula: see text] and the dAo versus leg tissue [Formula: see text].	Oxygen	59-65	down and out	Drosophila melanogaster	207-210
24070090-7	2014	Leukocyte activation abated in the presence of inhibitors of HMGB1 or of catalase, which catalyzes the dismutation of hydrogen peroxide into water and molecular oxygen.	Oxygen	161-167	high mobility group box 1	Homo sapiens	61-66
24353279-3	2014	This reaction is catalyzed by lanosterol 14alpha demethylase (CYP51) and requires three oxygen molecules.	Oxygen	88-94	cytochrome P450, family 51	Mus musculus	30-60
24353279-3	2014	This reaction is catalyzed by lanosterol 14alpha demethylase (CYP51) and requires three oxygen molecules.	Oxygen	88-94	cytochrome P450, family 51	Mus musculus	62-67
24184720-5	2014	Multilayered corneal epithelial cell sheets were fabricated using an oxygen-controlled method, and immunofluorescence analysis showed that cytokeratin 3 and p63 was expressed in appropriate localization in the cell sheets.	Oxygen	69-75	transformation related protein 63	Mus musculus	157-160
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	148-150	cytosolic iron-sulfur assembly component 3	Homo sapiens	11-47
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	148-150	cytosolic iron-sulfur assembly component 3	Homo sapiens	49-53
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	178-180	cytosolic iron-sulfur assembly component 3	Homo sapiens	11-47
23639116-2	2014	In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal atmospheric partial O2 pressure (normoxia, 21 kPa O2).	Oxygen	178-180	cytosolic iron-sulfur assembly component 3	Homo sapiens	49-53
23639116-3	2014	In yeasts, the nar1 mutant cannot grow at 21 kPa O2, but can develop at a lower O2 pressure (2 kPa O2).	Oxygen	49-51	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	15-19
23639116-3	2014	In yeasts, the nar1 mutant cannot grow at 21 kPa O2, but can develop at a lower O2 pressure (2 kPa O2).	Oxygen	80-82	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	15-19
27807688-8	2017	NOX4 promoted more rapid generation of H2O2 via the JNK pathway than generation of O2 - via ERK1/2 and p38 pathways.	Oxygen	41-43	NADPH oxidase 4	Homo sapiens	0-4
23639116-3	2014	In yeasts, the nar1 mutant cannot grow at 21 kPa O2, but can develop at a lower O2 pressure (2 kPa O2).	Oxygen	80-82	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	15-19
23703536-8	2014	The KLF8 may play a vital role in the pathogenesis of PE as a novel oxygen tension sensor.	Oxygen	68-74	Kruppel like factor 8	Homo sapiens	4-8
24481674-3	2014	For this purpose, we applied surface-enhanced Raman spectroscopy (SERS) to find out the mechanism of SPR-assisted activation of oxygen, by using p-aminothiophenol (PATP), which undergoes a SPR-assisted selective oxidation, as a probe molecule.	Oxygen	128-134	sepiapterin reductase	Homo sapiens	101-104
24481674-3	2014	For this purpose, we applied surface-enhanced Raman spectroscopy (SERS) to find out the mechanism of SPR-assisted activation of oxygen, by using p-aminothiophenol (PATP), which undergoes a SPR-assisted selective oxidation, as a probe molecule.	Oxygen	128-134	sepiapterin reductase	Homo sapiens	189-192
24481674-5	2014	Both experiments and DFT calculations reveal that oxygen molecules were activated by accepting an electron from a metal nanoparticle under the excitation of SPR to form a strongly adsorbed oxygen molecule anion.	Oxygen	50-56	sepiapterin reductase	Homo sapiens	157-160
24481674-5	2014	Both experiments and DFT calculations reveal that oxygen molecules were activated by accepting an electron from a metal nanoparticle under the excitation of SPR to form a strongly adsorbed oxygen molecule anion.	Oxygen	189-195	sepiapterin reductase	Homo sapiens	157-160
27688202-4	2017	Mean blood oxygen-level dependent (BOLD) responses disclosed bilateral activation of the frontal eye fields during exposure to light geared towards melanopsin.	Oxygen	11-17	opsin 4	Homo sapiens	148-158
24134622-4	2014	Exposure of hASCs for 10 days under hypoxia (3% oxygen) in combination with leptin increased the percentage of CD31(+) endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor, and endothelial cell nitric oxide synthase mRNA expression.	Oxygen	48-54	platelet and endothelial cell adhesion molecule 1	Homo sapiens	111-115
24134622-4	2014	Exposure of hASCs for 10 days under hypoxia (3% oxygen) in combination with leptin increased the percentage of CD31(+) endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor, and endothelial cell nitric oxide synthase mRNA expression.	Oxygen	48-54	platelet and endothelial cell adhesion molecule 1	Homo sapiens	148-152
25521129-2	2014	The performance of the MDC was evaluated for chemical oxygen demand (COD) removal, total dissolved solids (TDS) removal and energy production.	Oxygen	54-60	C-C motif chemokine ligand 22	Homo sapiens	23-26
28042952-5	2017	UCP2 downregulation also altered metabolic rates as shown by elevated glucose uptake and reduced oxygen consumption.	Oxygen	97-103	uncoupling protein 2	Homo sapiens	0-4
24436993-0	2013	Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury.	Oxygen	22-28	matrix metallopeptidase 2	Rattus norvegicus	32-37
24436993-1	2013	AIMS: To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI).	Oxygen	44-50	matrix metallopeptidase 2	Rattus norvegicus	68-73
24290753-6	2013	The thermogenic density (UCP1-dependent oxygen consumption per g tissue) of inguinal white adipose tissue was maximally one-fifth of interscapular brown adipose tissue, and the total quantitative contribution of all inguinal mitochondria was maximally one-third of all interscapular brown-fat mitochondria, indicating that the classical brown adipose tissue depots would still predominate in thermogenesis.	Oxygen	40-46	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	25-29
24134622-4	2014	Exposure of hASCs for 10 days under hypoxia (3% oxygen) in combination with leptin increased the percentage of CD31(+) endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor, and endothelial cell nitric oxide synthase mRNA expression.	Oxygen	48-54	TEK receptor tyrosine kinase	Homo sapiens	174-178
24505420-7	2014	While generation of O2(-)/ONOO(-) in Cr(VI) exposed Drosophila hemocytes was found to be responsible for the suppression of Drosophila cellular immune response, Cr(VI) induced alteration was significantly reduced by the over-expression of sod in Drosophila hemocytes.	Oxygen	20-22	Superoxide dismutase 1	Drosophila melanogaster	239-242
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Oxygen	114-116	glutathione peroxidase 7	Homo sapiens	20-24
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Oxygen	114-116	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-28
24108391-6	2014	In the metabolic syndrome, almost 2-fold increased mitochondrial O2 - significantly upregulated AT1 expressions by ~60%, companied by elevated Ca2+ and IP3 levels in VSMC and enhanced aortic rings contraction.	Oxygen	65-67	angiotensin II receptor, type 1a	Rattus norvegicus	96-99
24229319-1	2013	Dioxygen addition to coordinatively unsaturated [Fe(II)(O(Me2)N4(6-Me-DPEN))](PF6) (1) is shown to afford a complex containing a dihydroxo-bridged Fe(III)2(mu-OH)2 diamond core, [Fe(III)(O(Me2)N4(6-Me-DPEN))]2(mu-OH)2(PF6)2 (CH3CH2CN)2 (2).	Oxygen	0-8	sperm associated antigen 17	Homo sapiens	78-81
28685462-2	2017	Both 1/T 1 and 1/T 2 increase with increasing oxygen concentration.	Oxygen	46-52	interleukin 1 receptor like 1	Homo sapiens	7-16
24229319-1	2013	Dioxygen addition to coordinatively unsaturated [Fe(II)(O(Me2)N4(6-Me-DPEN))](PF6) (1) is shown to afford a complex containing a dihydroxo-bridged Fe(III)2(mu-OH)2 diamond core, [Fe(III)(O(Me2)N4(6-Me-DPEN))]2(mu-OH)2(PF6)2 (CH3CH2CN)2 (2).	Oxygen	0-8	sperm associated antigen 17	Homo sapiens	218-221
23884959-3	2013	Under pathological hypoxia, the catalytic activities of JMJD2A, JMJD2C and Jumonji/ARID domain-containing protein 1B (JARID1B) were blocked due to the lack of their substrate, i.e. oxygen.	Oxygen	181-187	lysine demethylase 5B	Homo sapiens	75-116
23884959-3	2013	Under pathological hypoxia, the catalytic activities of JMJD2A, JMJD2C and Jumonji/ARID domain-containing protein 1B (JARID1B) were blocked due to the lack of their substrate, i.e. oxygen.	Oxygen	181-187	lysine demethylase 5B	Homo sapiens	118-125
28574047-9	2017	Using ACP during CA in Group One patients maintained the oxygen status of the brain at an optimal level.	Oxygen	57-63	CPAT1	Homo sapiens	6-9
24154626-9	2013	To our knowledge, we demonstrate for the first time that pan-T cell, PD-1-mediated, exhaustion during VL influenced macrophage-reactive oxygen intermediate production.	Oxygen	136-142	programmed cell death 1	Canis lupus familiaris	69-73
24359819-10	2014	In contrast, the expression of type 2 purinergic receptors (P2RX4 and PR2Y11), an ATP release channel (gap junction hemichannel GJB1), and an adenosine uptake protein (SLC29A1) followed the opposite response, increasing after calving and remaining elevated through 21 d. Haptoglobin, ceruloplasmin, and reactive oxygen metabolite concentrations increased gradually from d -21 d through at least d 7.	Oxygen	312-318	solute carrier family 29 member 1	Bos taurus	168-175
24227162-7	2014	The electron transfer reaction from (3)MPS* to O2 yielding MPS (+) and O2 (-) is also enhanced in SDS micelles, as back electron transfer (BET) is prevented by ejection of O2 (-) to the aqueous bulk phase and stabilization of MPS (+) in the anionic micelles.	Oxygen	47-49	delta/notch like EGF repeat containing	Homo sapiens	139-142
24227162-7	2014	The electron transfer reaction from (3)MPS* to O2 yielding MPS (+) and O2 (-) is also enhanced in SDS micelles, as back electron transfer (BET) is prevented by ejection of O2 (-) to the aqueous bulk phase and stabilization of MPS (+) in the anionic micelles.	Oxygen	71-73	delta/notch like EGF repeat containing	Homo sapiens	139-142
24227162-7	2014	The electron transfer reaction from (3)MPS* to O2 yielding MPS (+) and O2 (-) is also enhanced in SDS micelles, as back electron transfer (BET) is prevented by ejection of O2 (-) to the aqueous bulk phase and stabilization of MPS (+) in the anionic micelles.	Oxygen	71-73	delta/notch like EGF repeat containing	Homo sapiens	139-142
27694478-0	2017	Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.	Oxygen	51-57	flap structure specific endonuclease 1	Mus musculus	8-12
24114181-5	2013	NMB+ appeared similar to MB+, even though it produces (1)O2 much more efficiently, and was slightly influenced by the solvent.	Oxygen	54-59	neuromedin B	Homo sapiens	0-3
27694478-5	2017	This suggests an essential role for FEN1 phosphorylation in repairing oxygen-induced DNA damage and maintaining proper cell cycle progression.	Oxygen	70-76	flap structure specific endonuclease 1	Mus musculus	36-40
24284114-8	2013	CONCLUSIONS: Experimentation with human squamous epithelial carcinoma cells has indicated that the iron chelator CP94 significantly increased PpIX accumulation induced by each PpIX congener investigated (ALA/MAL/HAL) at all oxygen concentrations employed (5%/20%/40%) resulting in increased levels of photobleaching and reduced cell viability on irradiation.	Oxygen	224-230	beaded filament structural protein 1	Homo sapiens	113-117
24475268-9	2014	Phosphorylation of ArcA, the regulator of the two-component system ArcBA, besides Fnr the main transcription factor for the response towards different oxygen concentrations, was studied.	Oxygen	151-157	arginine deiminase	Escherichia coli	19-23
27733447-6	2017	An ER-beta-selective ligand increased markers of tricarboxylic acid-dependent and -independent energy biogenesis and oxygen consumption in mice without a concomitant increase in physical activity or food consumption, all culminating in significantly reduced weight gain and adiposity.	Oxygen	117-123	estrogen receptor 2 (beta)	Mus musculus	3-10
27864359-11	2017	The roles of tumor necrosis factor (TNF)-alpha (25 ng/ml) and oxygen (1%) in ET-1 regulation of MMP14 and 15 expression were assessed by Western blotting.	Oxygen	62-68	matrix metallopeptidase 14	Homo sapiens	96-101
23318452-9	2014	Like Lto1, the Rli1/ABCE1 [4Fe-4S] clusters are not required for viability under anaerobic conditions, but are essential in the presence of oxygen.	Oxygen	140-146	Fe-S cluster-binding ribosome biosynthesis protein	Saccharomyces cerevisiae S288C	15-19
24100076-1	2013	Ascorbate oxidase (AO) is an apoplastic enzyme that uses oxygen to catalyse the oxidation of ascorbate (AA) to dehydroascorbate (DHA) via the unstable radical monodehydroascorbate (MDHA).	Oxygen	57-63	L-ascorbate oxidase-like	Nicotiana tabacum	0-17
23808372-5	2013	The 1-hydroxybut-1-yl + O2 reaction is dominated by direct HO2 elimination from the corresponding peroxy radical forming butanal as the stable coproduct.	Oxygen	98-112	heme oxygenase 2	Homo sapiens	59-62
24049142-6	2013	Thus, TGF-beta1 increases mitochondrial oxygen consumption and ATP generation in the presence of diverse energy substrates.	Oxygen	40-46	transforming growth factor, beta 1	Mus musculus	6-15
24372305-5	2014	In this regard, results of oxygen plasma treatment of a-C and CNx films are presented.	Oxygen	27-33	calnexin	Homo sapiens	62-65
24372305-7	2014	The CNx films were found to be much less resistant to oxygen etching than the a-C film.	Oxygen	54-60	calnexin	Homo sapiens	4-7
24448514-3	2014	In particular, the ternary Au@Ag2S-Pt nanocomposites display superior methanol oxidation reaction (MOR) selectivity due to the electronic coupling effect among different domains of the nanocomposites, while the cage-bell structured Pt-Ru nanoparticles exhibit excellent methanol tolerance for oxygen reduction reaction (ORR) at the cathode because of the differential diffusion of methanol and oxygen in the porous Ru shell of the cage-bell nanoparticles.	Oxygen	394-400	angiotensin II receptor type 1	Homo sapiens	30-34
27848178-1	2017	The TET dioxygenases, TET1, TET2, and TET3, catalyze transfer of an oxygen atom to the methyl group of 5-methylcytocine (5-mC), converting it to 5-hydroxymethylcytocine (5-hmC).	Oxygen	10-16	tet methylcytosine dioxygenase 2	Homo sapiens	28-32
24482687-4	2014	The mRNA and protein expression of IL-6, MCP-1 and SePP1 were detected in preadipocytes under normoxic (21% O2) and hyperoxic (4% O2) conditions, and the impact of IL-6, MCP-1 and SePP1 on VF was investigated.	Oxygen	108-110	selenoprotein P	Rattus norvegicus	51-56
24482687-4	2014	The mRNA and protein expression of IL-6, MCP-1 and SePP1 were detected in preadipocytes under normoxic (21% O2) and hyperoxic (4% O2) conditions, and the impact of IL-6, MCP-1 and SePP1 on VF was investigated.	Oxygen	130-132	selenoprotein P	Rattus norvegicus	51-56
24244514-6	2013	Our results demonstrate that exposure to hypoxia (10% O2) for 3-weeks increased levels of miR-27a and ET-1 in the lungs of C57BL/6 mice and reduced PPARgamma levels.	Oxygen	54-56	peroxisome proliferator activated receptor gamma	Mus musculus	148-157
28845732-0	2017	Kindlin-1 is a key protein in hyperbaric oxygen therapy for the treatment of neuropathic pain.	Oxygen	41-47	FERM domain containing kindlin 1	Rattus norvegicus	0-9
24160875-6	2013	The emission intensity ratio of the Hg atom to NO (IHg/INO) was analyzed to evaluate the LIBS detection limit because the NO emission (interference signal) was formed during the plasma generation and cooling process of N2 and O2 in the air.	Oxygen	226-228	IHG1	Homo sapiens	51-54
24184117-4	2014	Genetic deletion of beta2-nAChRs associated with reduced terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL(+)) and cleaved caspase-3(+) cells after MCAO, together with a reduction of extracellular glutamate and oxygen-glucose deprivation-induced increase of excitatory inputs in cortical neurons.	Oxygen	244-250	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	20-25
29171348-8	2017	In nine patients with 51 PMV applications, we observed three undesirable events in terms of dyspnea and oxygen desaturation.	Oxygen	104-110	Mitral valve prolapse, familial	Homo sapiens	25-28
23725018-10	2014	Finally, the role of nSMase in acute oxygen sensing was also observed in human PA and DA.	Oxygen	37-43	sphingomyelin phosphodiesterase 2	Homo sapiens	21-27
23913859-7	2013	Moreover, using a murine treatment model of bleomycin-induced pulmonary fibrosis we found that inhibition of TGFbeta/PDGF and ErbB pathways with imatinib plus lapatinib, respectively, not only prevented myofibroblast gene expression to a greater extent than either drug alone, but also essentially stabilized gas exchange (oxygen saturation) as an overall measure of lung function.	Oxygen	323-329	transforming growth factor, beta 1	Mus musculus	109-116
28108649-3	2017	Therefore, this study set out to test the hypothesis that the restriction in mV O2 is regulated by the net decrease in intracellular oxygen tension equilibrated with myoglobin oxygen saturation ( PmbO2) during muscle contraction under hypoxic conditions.	Oxygen	176-182	myoglobin	Rattus norvegicus	166-175
24386511-5	2013	The presence of common consensus prolyl hydroxylation and pVHL binding motifs (L(XY)LAP);LLPLAP(2191) suggested an oxygen-dependent regulation for NICD3.	Oxygen	115-121	von Hippel-Lindau tumor suppressor	Homo sapiens	58-62
24095673-9	2014	Strikingly, HO2 radicals were an order of magnitude more concentrated in the headgroups region than in water, implying a large shift in the acid-base equilibrium between HO2 and O2(-).	Oxygen	13-15	heme oxygenase 2	Homo sapiens	170-173
28108649-5	2017	The  [deoxy-Mb] kinetics were converted to oxygen saturation of myoglobin (SmbO2), and the PmbO2 was then calculated based on the SmbO2 and the O2 dissociation curve of the Mb.	Oxygen	43-49	myoglobin	Rattus norvegicus	64-73
28769017-0	2017	TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing.	Oxygen	16-22	transient receptor potential cation channel subfamily A member 1	Homo sapiens	82-87
25366234-5	2014	A truly polymodal ion channel, TRPA1 is activated by various stimuli, including electrophilic chemicals, oxygen, temperature, and mechanical force, yet the molecular mechanism of TRPA1 gating remains obscure.	Oxygen	105-111	transient receptor potential cation channel subfamily A member 1	Homo sapiens	31-36
24166752-0	2014	Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system.	Oxygen	24-30	renin	Rattus norvegicus	116-121
24166752-2	2014	Transient neonatal high O(2) exposure in rat in adulthood (a model of preterm birth-related complications) leads to elevated blood pressure, vascular rigidity, and dysfunction with renin-angiotensin system activation.	Oxygen	24-28	renin	Rattus norvegicus	181-186
24166752-6	2014	At 16 weeks, hearts from O(2)-exposed rats showed cardiomyocyte hypertrophy, enhanced fibrosis, and increased expression of transforming growth factor-beta1, senescence-associated proteins p53 and Rb, upregulation of angiotensin II type 1 (AT1) receptor expression (protein and AT1a/b mRNA), and downregulation of AT2 receptors.	Oxygen	25-29	angiotensin II receptor, type 1a	Rattus norvegicus	278-282
24166752-6	2014	At 16 weeks, hearts from O(2)-exposed rats showed cardiomyocyte hypertrophy, enhanced fibrosis, and increased expression of transforming growth factor-beta1, senescence-associated proteins p53 and Rb, upregulation of angiotensin II type 1 (AT1) receptor expression (protein and AT1a/b mRNA), and downregulation of AT2 receptors.	Oxygen	25-29	angiotensin II receptor, type 2	Rattus norvegicus	314-317
24166752-7	2014	At 4 weeks (before blood pressure increase), the expression of cardiomyocyte surface area, fibrosis, p53, and AT1b was significantly increased and AT2 decreased in O(2)-exposed animals.	Oxygen	164-168	angiotensin II receptor, type 2	Rattus norvegicus	147-150
24084221-1	2014	This study describes the effect of variable oxygen supply on relaxing responses induced by alpha-calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) on isolated pig coronary arteries in vitro.	Oxygen	44-50	adrenomedullin	Sus scrofa	140-154
24337603-7	2014	Colocalization with hypoxia as measured by EF5 immunohistochemistry is evident for both at 16 h after administration but not at 15 min or 2 h. Interestingly, at 2 h tumor retention for (64)Cu-acetate and (64)Cu-ATSM, although not colocalizing with hypoxia, is reduced by similar amounts by increased tumor oxygenation due to inhalation of increased O2.	Oxygen	349-351	angiogenin, ribonuclease A family, member 3	Mus musculus	43-46
25158160-8	2014	A multicenter, double-blind, placebo-controlled phase III clinical trial in Japan and a US phase II clinical trial of HGF gene therapy for critical limb ischemia (CLI) demonstrated a significant improvement in primary end points and an increase in transcutaneous partial pressure of oxygen even after one year compared with placebo, whereas effectiveness of VEGF and FGF treatment for CLI has not yet been shown.	Oxygen	283-289	hepatocyte growth factor	Homo sapiens	118-121
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	interleukin 9	Homo sapiens	262-265
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	117-133
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	135-139
25136403-11	2014	Finally, we call attention on the role of HO-2 in oxygen sensing, discussing proposed hypothesis on heme binding motifs and redox/thiol switches that participate in oxygen sensing as well as evidences of HO-2 response to hypoxia.	Oxygen	50-56	heme oxygenase 2	Homo sapiens	42-46
24741770-2	2014	Studies have revealed that mutant huntingtin, polyglutamine-expanded ataxin-1 and ataxin-3 can cause elevated levels of reactive oxygen species in neuronal cells.	Oxygen	129-135	huntingtin	Homo sapiens	34-44
24146383-2	2014	Tumor-specific, hypoxia-induced upregulation of Carbonic Anhydrase IX (CAIX) is a component of the complex response of cancer cells to the evolving low oxygen environment.	Oxygen	152-158	carbonic anhydrase 9	Homo sapiens	48-69
24146383-2	2014	Tumor-specific, hypoxia-induced upregulation of Carbonic Anhydrase IX (CAIX) is a component of the complex response of cancer cells to the evolving low oxygen environment.	Oxygen	152-158	carbonic anhydrase 9	Homo sapiens	71-75
24349516-7	2013	Furthermore, there were differential changes in levels of beclin-1, DRAM, and LC3B-II in response to changes in oxygen and glucose levels.	Oxygen	112-118	microtubule associated protein 1 light chain 3 beta	Homo sapiens	78-82
22937827-1	2013	SIGNIFICANCE: Cytochrome c oxidase (COX), the last enzyme of the mitochondrial respiratory chain, is the major oxygen consumer enzyme in the cell.	Oxygen	111-117	cytochrome c oxidase subunit 8A	Homo sapiens	36-39
22937827-5	2013	These include: (i) Intricate redox-controlled machineries coordinate the expression of COX isoenzymes depending on the environmental oxygen concentration.	Oxygen	133-139	cytochrome c oxidase subunit 8A	Homo sapiens	87-90
23880643-9	2013	Fifteen cytokines/chemokines including Type 2 cytokines IL-13, MCP-1, and CD40 ligand were detected in ambient O2 ASC medium.	Oxygen	111-113	CD40 molecule	Homo sapiens	74-78
24115172-6	2013	Interestingly, GR knockdown induces peroxiredoxin-1 overexpression in the air-exposed tissue and high oxygen consuming tissue such as cornea and liver, but not in the low oxygen consuming tissues such as breast and uterine.	Oxygen	102-108	glutathione-disulfide reductase	Homo sapiens	15-17
24115172-6	2013	Interestingly, GR knockdown induces peroxiredoxin-1 overexpression in the air-exposed tissue and high oxygen consuming tissue such as cornea and liver, but not in the low oxygen consuming tissues such as breast and uterine.	Oxygen	171-177	glutathione-disulfide reductase	Homo sapiens	15-17
23249140-1	2013	Catalase is an important antioxidant enzyme that catalyzes the disproportionation of H2O2 into harmless water and molecular oxygen.	Oxygen	124-130	catalase	Bos taurus	0-8
23813470-0	2013	AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture.	Oxygen	15-21	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-5
23813470-4	2013	Surprisingly, acute AICAR exposure at most concentrations (0.25-1.5 mM), but not all (0.1 mM), modestly inhibited oxygen consumption even though AICAR increased AMPK phosphorylation.	Oxygen	114-120	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	20-25
23813470-5	2013	The data suggest that AICAR inhibited oxygen consumption by the cultured muscle in a non-specific manner.	Oxygen	38-44	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	22-27
24045183-4	2013	EXPERIMENTAL DESIGN: Amplification and expression of LAMP3, a UPR metastasis-associated gene, was examined using FISH and immunofluorescence in a cohort of human cervix tumors from patients who had received oxygen needle electrode tumor oxygenation measurements.	Oxygen	207-213	lysosomal associated membrane protein 3	Homo sapiens	53-58
24106122-3	2013	We have analyzed the dependence of retinal neovascularization on the Nox2 isoform in oxygen-induced retinopathy (OIR) in mice.	Oxygen	85-91	cytochrome b-245, beta polypeptide	Mus musculus	69-73
24066857-0	2013	Circular dichroism, magnetic circular dichroism, and variable temperature variable field magnetic circular dichroism studies of biferrous and mixed-valent myo-inositol oxygenase: insights into substrate activation of O2 reactivity.	Oxygen	217-219	myo-inositol oxygenase	Homo sapiens	155-177
24066857-3	2013	The MCD spectrum of biferrous MIOX shows two ligand field (LF) transitions near 10000 cm(-1), split by ~2000 cm(-1), characteristic of six coordinate (6C) Fe(II) sites, indicating that the modest reactivity of the biferrous form toward O2 can be attributed to the saturated coordination of both irons.	Oxygen	236-238	myo-inositol oxygenase	Homo sapiens	30-34
24116043-7	2013	Also, in a mutant strain that only contains demethylmenaquinone, the extent of ArcA phosphorylation can be modulated by the oxygen supply rate, which shows that demethylmenaquinone can also inactivate ArcB in its oxidized form.	Oxygen	124-130	arginine deiminase	Escherichia coli	79-83
24355223-3	2013	A significant dose-dependent effect response of Ambroxol on O2&amp;#8254; production by cells coated with anti-CD11a antibody was observed.	Oxygen	60-62	integrin subunit alpha L	Homo sapiens	111-116
23733487-5	2013	When isp-1 and clk-1 mutants, which show reduced rates of oxygen intermediate production, were maintained at 20 and 25 C after pre-exposure to diacetyl, the mutants showed a shorter retention time of diacetyl adaptation compared with that of wild-type nematodes.	Oxygen	58-64	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Caenorhabditis elegans	5-10
23733487-5	2013	When isp-1 and clk-1 mutants, which show reduced rates of oxygen intermediate production, were maintained at 20 and 25 C after pre-exposure to diacetyl, the mutants showed a shorter retention time of diacetyl adaptation compared with that of wild-type nematodes.	Oxygen	58-64	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	15-20
23969990-0	2013	Effects of stromal cell derived factor-1 and CXCR4 on the promotion of neovascularization by hyperbaric oxygen treatment in skin flaps.	Oxygen	104-110	C-X-C motif chemokine ligand 12	Rattus norvegicus	11-40
24744985-0	2013	Neuronal cell fate decisions:  O2 and CO2 sensing neurons require egl-13/Sox5.	Oxygen	31-33	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	66-72
24744985-2	2013	We identified egl-13/Sox5 to be required for the differentiation of both O2 and CO2 sensing neurons.	Oxygen	73-75	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	14-20
24744985-3	2013	We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors.	Oxygen	58-60	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	14-20
24744985-3	2013	We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors.	Oxygen	66-68	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	14-20
24744985-4	2013	Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated.	Oxygen	144-146	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	37-43
24744985-4	2013	Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated.	Oxygen	144-146	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	90-96
24069415-5	2013	Demanding that the molecular changes induced by low ambient oxygen are reversed by Dasatinib in U251 cells, identifies neural Wiskott-Aldrich syndrome protein (NWASP), Focal adhesion Kinase (FAK), [Formula: see text]-Catenin, and Cofilin.	Oxygen	60-66	protein tyrosine kinase 2	Homo sapiens	191-194
24061475-9	2013	Moreover, oxygen deprivation destabilizes PHLPP protein by decreasing the expression of USP46, a deubiquitinase of PHLPP.	Oxygen	10-16	ubiquitin specific peptidase 46	Homo sapiens	88-93
23971408-6	2013	Among these, the rotenone-sensitive subunit of complex I NDUFV3 was increased in cells cultured at 5% oxygen.	Oxygen	102-108	NADH:ubiquinone oxidoreductase subunit V3	Homo sapiens	57-63
23879969-15	2013	Collectively, our results indicate that the involvement of autophagy in maintenance of CD133+ LCSCs under the oxygen- and nutrient-deprived conditions that are typical of the tumor microenvironment in HCC.	Oxygen	110-116	prominin 1	Homo sapiens	87-92
23721887-0	2013	Solution equilibria of anticancer ruthenium(II)-(eta(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity.	Oxygen	122-128	endothelin receptor type A	Homo sapiens	49-52
24084861-2	2013	The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species.	Oxygen	134-140	CREB regulated transcription coactivator 1	Mus musculus	4-10
24084861-2	2013	The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species.	Oxygen	134-140	CREB regulated transcription coactivator 1	Mus musculus	92-98
24151298-7	2013	Furthermore, in cyanobacteria, the CPP1 homolog critically regulates POR accumulation and chlorophyll synthesis under high-light conditions, in which the dark-operative Pchlide oxidoreductase is repressed by its oxygen sensitivity.	Oxygen	212-218	cell growth defect factor-like protein (DUF3353)	Arabidopsis thaliana	35-39
23940035-0	2013	Structural snapshots from the oxidative half-reaction of a copper amine oxidase: implications for O2 activation.	Oxygen	98-100	amine oxidase copper containing 3	Homo sapiens	59-79
23940035-1	2013	The mechanism of molecular oxygen activation is the subject of controversy in the copper amine oxidase family.	Oxygen	27-33	amine oxidase copper containing 3	Homo sapiens	82-102
24058604-10	2013	Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships.	Oxygen	152-158	solute carrier family 12, member 2	Mus musculus	95-100
23268198-4	2013	We observed 7-fold overexpression of HK2 gene in D atria with concomitant 2-fold greater activation of mitochondrial oxygen consumption by glucose, which might represent an adaption to increased energy requirements and impaired mitochondrial function by effectively joining glycolysis and oxidative phosphorylation.	Oxygen	117-123	hexokinase 2	Homo sapiens	37-40
23764543-7	2013	Elevated CTH reduces the extraction of oxygen, glucose, and cytotoxic molecules.	Oxygen	39-45	V-set and immunoglobulin domain containing 2	Homo sapiens	9-12
23764543-9	2013	The extraction of oxygen and glucose are affected to different extents by elevated CTH, and the degree of aerobic glycolysis-known as the Warburg effect-is thus predicted to represent an adaptation to the CTH of the local microvasculature.	Oxygen	18-24	V-set and immunoglobulin domain containing 2	Homo sapiens	83-86
28769017-0	2017	TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing.	Oxygen	91-93	transient receptor potential cation channel subfamily A member 1	Homo sapiens	82-87
23932902-0	2013	PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.	Oxygen	37-43	egl-9 family hypoxia inducible factor 2	Homo sapiens	0-4
28769017-2	2017	Here, we overview a group of TRP channels that respond to reactive redox species to transduce physiological signals, with a focus on TRPA1 and its role in oxygen physiology.	Oxygen	155-161	transient receptor potential cation channel subfamily A member 1	Homo sapiens	133-138
23932902-3	2013	Here, we identify PHD1 as a critical molecular link between oxygen sensing and cell-cycle control.	Oxygen	60-66	egl-9 family hypoxia inducible factor 2	Homo sapiens	18-22
28769017-3	2017	Our systematic evaluation of oxidation sensitivity using cysteine-selective reactive disulphides with different redox potentials reveals that TRPA1 has the highest sensitivity to oxidants/electrophiles among the TRP channels, which enables it to sense O2.	Oxygen	252-254	transient receptor potential cation channel subfamily A member 1	Homo sapiens	142-147
24377245-7	2013	At the high dissolved oxygen level the CAT activity of E. coli JM109/pDXW-Ptkt-cat and C. crenatum SYPA5-5/pDXW-Ptkt-cat were 3.032 U/mg and 1.987 U/mg, which were 2.8-fold and 3.2-fold than that in the low dissolved oxygen, respectively.	Oxygen	217-223	chloramphenicol acetyltransferase	Escherichia coli	117-120
28769017-4	2017	Proline hydroxylation by O2-dependent hydroxylases also regulates the O2-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cysteine oxidation that overrides the inhibition.	Oxygen	25-27	transient receptor potential cation channel subfamily A member 1	Homo sapiens	104-109
28769017-4	2017	Proline hydroxylation by O2-dependent hydroxylases also regulates the O2-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cysteine oxidation that overrides the inhibition.	Oxygen	25-27	transient receptor potential cation channel subfamily A member 1	Homo sapiens	123-128
28769017-5	2017	TRPA1 enhances neuronal discharges induced by hyperoxia and hypoxia in the vagus to underlie respiratory adaptation to changes in O2 availability.	Oxygen	130-132	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
23977201-7	2013	The activation of p38 is associated with the presence of reactive oxygen species (ROS) produced by rotenone.	Oxygen	66-72	mitogen-activated protein kinase 14	Mus musculus	18-21
27916458-8	2016	Low environmental oxygen also induces conditioned place aversion, for which Gucy1b2 and Trpc2 are required.	Oxygen	18-24	transient receptor potential cation channel, subfamily C, member 2	Mus musculus	88-93
23517783-11	2013	Together, these results indicate that the actin cytoskeletal reorganization due to the ROS/RhoA-ROCK pathway mediates myofibroblast transformation and collagen synthesis in lung fibrosis of oxygen toxicity.	Oxygen	190-196	ras homolog family member A	Mus musculus	91-95
23380177-13	2013	These data suggest a role for the short-term administration of low-dose O2 to prevent both IH and SMCp after creation of an AVF that may prolong patency and function.	Oxygen	72-74	SMCP	Oryctolagus cuniculus	98-102
23481873-1	2013	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Danio rerio	0-11
23481873-1	2013	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Danio rerio	13-16
24086110-4	2013	Here we show that hypoxia-controlled expression of the transcription factor Hand1 determines oxygen consumption by inhibition of lipid metabolism in the fetal and adult cardiomyocyte, leading to downregulation of mitochondrial energy generation.	Oxygen	93-99	heart and neural crest derivatives expressed 1	Mus musculus	76-81
24086110-8	2013	Using metabolic flux analysis, we show that Hand1 expression controls cardiomyocyte oxygen consumption by direct transcriptional repression of lipid metabolising genes.	Oxygen	84-90	heart and neural crest derivatives expressed 1	Mus musculus	44-49
24086110-12	2013	We propose that Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.	Oxygen	76-82	heart and neural crest derivatives expressed 1	Mus musculus	16-21
24086110-12	2013	We propose that Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.	Oxygen	95-101	heart and neural crest derivatives expressed 1	Mus musculus	16-21
23639789-0	2013	Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons.	Oxygen	36-42	neuroglobin	Mus musculus	0-11
27824191-4	2016	Notably, the prepared N,S-hcs electrocatalysts provided four electron oxygen reduction selectivity, long-term durability and high resistance to methanol poisoning, all of which represented improvements over the conventional Pt/C electrocatalyst.	Oxygen	70-76	holocarboxylase synthetase	Homo sapiens	26-29
23977224-7	2013	When added to isolated mitochondria, DIF-3, Bu-DIF-3, and BOIDPY-DIF-3, like CCCP, dose-dependently promoted the rate of oxygen consumption, but Bu-BODIPY did not.	Oxygen	121-127	gametogenetin binding protein 2	Homo sapiens	37-42
27844077-0	2016	Fe-oxy adducts of heme-Abeta and heme-hIAPP complexes: intermediates in ROS generation.	Oxygen	3-6	islet amyloid polypeptide	Homo sapiens	38-43
23977224-7	2013	When added to isolated mitochondria, DIF-3, Bu-DIF-3, and BOIDPY-DIF-3, like CCCP, dose-dependently promoted the rate of oxygen consumption, but Bu-BODIPY did not.	Oxygen	121-127	gametogenetin binding protein 2	Homo sapiens	47-52
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Oxygen	148-154	S-phase kinase associated protein 2	Homo sapiens	67-71
27519633-6	2016	These results suggest that low oxygen level stimulates the HIF1-VEGF-AKT-mTOR pathway and up-regulates glycolysis, which contributes to GC proliferation, and downregulation of SIRT1 contributes to hypoxia-associated reduction of mitochondria and cellular proliferation.	Oxygen	31-37	AKT serine/threonine kinase 1	Bos taurus	69-72
23977224-7	2013	When added to isolated mitochondria, DIF-3, Bu-DIF-3, and BOIDPY-DIF-3, like CCCP, dose-dependently promoted the rate of oxygen consumption, but Bu-BODIPY did not.	Oxygen	121-127	gametogenetin binding protein 2	Homo sapiens	47-52
27519633-6	2016	These results suggest that low oxygen level stimulates the HIF1-VEGF-AKT-mTOR pathway and up-regulates glycolysis, which contributes to GC proliferation, and downregulation of SIRT1 contributes to hypoxia-associated reduction of mitochondria and cellular proliferation.	Oxygen	31-37	mechanistic target of rapamycin kinase	Bos taurus	73-77
23603614-4	2013	It was found that hypoxia (3% O2) significantly affected the expression of a range of angiogenesis-related factors including VEGF, angiogenin and thrombospondin-1, relative to the normoxic baseline.	Oxygen	30-32	angiogenin	Homo sapiens	131-141
27693634-6	2016	In this study, we demonstrated that pVHL inhibits NF-kappaB by mediating K63-ubiquitination of IKKbeta, which is dependent on oxygen.	Oxygen	126-132	von Hippel-Lindau tumor suppressor	Homo sapiens	36-40
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	Oxygen	41-47	NADPH oxidase 4	Homo sapiens	130-145
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	Oxygen	58-60	NADPH oxidase 4	Homo sapiens	130-145
27753705-8	2016	Results of multinomial logistic regression analysis indicated that BNP level was a significant determinant for the riser pattern [odds ratio (OR) 1.27 (BNP 10 pg/ml), P &lt; 0.001], whereas oxygen desaturation was specifically associated with the nondipping pattern (OR 1.04, P = 0.001).	Oxygen	190-196	natriuretic peptide B	Homo sapiens	67-70
23677698-2	2013	Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here.	Oxygen	31-38	nucleobindin 1	Homo sapiens	18-21
23677698-2	2013	Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here.	Oxygen	31-37	nucleobindin 1	Homo sapiens	18-21
23739770-0	2013	Effects of a Rho kinase inhibitor on the sequential expression of ICAM-1, HIF-1alpha, Bcl-2 and caspase-3 in the retina of rats with oxygen-induced retinopathy.	Oxygen	133-139	caspase 3	Rattus norvegicus	96-105
23380177-2	2013	Our laboratory has previously demonstrated the role of supplemental oxygen in preventing IH and smooth muscle cell proliferation (SMCp) at an artery-to-graft anastomosis and at the deployment site of an intra-arterial stent.	Oxygen	68-74	SMCP	Oryctolagus cuniculus	130-134
23380177-3	2013	This study examines the effect of supplemental oxygen in preventing IH and SMCp in an AVF in a rabbit model.	Oxygen	47-53	SMCP	Oryctolagus cuniculus	75-79
23380177-10	2013	SMCp was noted at day 3 through day 21 in the nonoxygen-supplemented group, whereas almost no SMCp was noted in the oxygen-supplemented group at any location or time point.	Oxygen	49-55	SMCP	Oryctolagus cuniculus	0-4
24024174-4	2013	PDI was S-nitrosylated when RBCs were exposed to nitrite under ~50% oxygen saturation but not under ~100% oxygen saturation.	Oxygen	68-74	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-3
23578765-2	2013	Using the Hv1 inhibitor Zn(2+), we found that the PMA-induced respiratory burst of human neutrophils is inhibited when assessed as extracellular production of O2(-) and H2O2, in accordance with literature studies, but, surprisingly, unaffected when measured as oxygen consumption or total (extracellular plus intracellular) H2O2 production.	Oxygen	159-161	hydrogen voltage gated channel 1	Homo sapiens	10-13
23578765-2	2013	Using the Hv1 inhibitor Zn(2+), we found that the PMA-induced respiratory burst of human neutrophils is inhibited when assessed as extracellular production of O2(-) and H2O2, in accordance with literature studies, but, surprisingly, unaffected when measured as oxygen consumption or total (extracellular plus intracellular) H2O2 production.	Oxygen	261-267	hydrogen voltage gated channel 1	Homo sapiens	10-13
23211047-5	2013	The levels of calsenilin and presenilin were increased in primary neurons after oxygen and glucose deprivation.	Oxygen	80-86	potassium voltage-gated channel interacting protein 3	Homo sapiens	14-24
24137597-2	2013	TRPM8 activation leads to earlier heat-initiated increase in oxygen consumption, but reduces its magnitude.	Oxygen	61-67	transient receptor potential cation channel subfamily M member 8	Homo sapiens	0-5
23434931-6	2013	Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).	Oxygen	11-17	transcription factor 7 like 2, T cell specific, HMG box	Mus musculus	72-78
23434931-6	2013	Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).	Oxygen	11-17	transcription factor 7 like 2, T cell specific, HMG box	Mus musculus	141-147
23722227-8	2013	A drastic reduction of oxygen consumption was observed due to mitochondrial membrane damage, which was accompanied by a decrease in the levels of VDAC1 integral membrane channel.	Oxygen	23-29	voltage dependent anion channel 1	Homo sapiens	146-151
23307012-9	2013	Treatment with H2S reduced lung permeability and suppressed VEGF release and VEGFR2 expression in lungs of mice under oxygen exposure.	Oxygen	118-124	kinase insert domain protein receptor	Mus musculus	77-83
23584901-0	2013	Estrogen-related receptor gamma (ERRgamma) regulates oxygen-dependent expression of voltage-gated potassium (K+) channels and tissue kallikrein during human trophoblast differentiation.	Oxygen	53-59	estrogen related receptor gamma	Homo sapiens	0-31
23584901-0	2013	Estrogen-related receptor gamma (ERRgamma) regulates oxygen-dependent expression of voltage-gated potassium (K+) channels and tissue kallikrein during human trophoblast differentiation.	Oxygen	53-59	estrogen related receptor gamma	Homo sapiens	33-41
23584901-3	2013	Expression of KLK1 and the KV7 channel subunits, KCNQ1, KCNE1, KCNE3, and KCNE5, increased during differentiation of cultured human trophoblast cells in a 20% O2 environment.	Oxygen	159-161	kallikrein 1	Homo sapiens	14-18
23584901-4	2013	Notably, together with ERRgamma, expression of KLK1, KCNQ1, KCNE1, KCNE3, and KCNE5 was markedly reduced when cells were cultured in a hypoxic environment (2% O2).	Oxygen	159-161	kallikrein 1	Homo sapiens	47-51
23728461-4	2013	The emerging network of signalling pathways through which mTORC1 integrates systemic signals (secreted growth factors) with local signals (cellular nutrients - amino acids, glucose and oxygen - and energy, ATP) is detailed.	Oxygen	185-191	CREB regulated transcription coactivator 1	Mus musculus	58-64
23544864-1	2013	Transparency, flexibility, and especially ultralow oxygen (OTR) and water vapor (WVTR) transmission rates are the key issues to be addressed for packaging of flexible organic photovoltaics and organic light-emitting diodes.	Oxygen	51-57	oxytocin receptor	Homo sapiens	59-62
23611340-8	2013	Heme(Fe(2+))-hIAPP complexes are prone to produce partially reduced oxygen species (PROS).	Oxygen	68-74	islet amyloid polypeptide	Homo sapiens	13-18
23668766-5	2013	The phase II time constant for VO2p (tauVO2p) was reduced in Mod 2 (22 s (Mod 1), 19 s (Mod 2); p &lt; 0.05), as was the "overshoot" in the normalized [HHb]/O2 uptake ratio (p &lt; 0.05).	Oxygen	32-34	chromobox 3	Homo sapiens	61-66
23668766-5	2013	The phase II time constant for VO2p (tauVO2p) was reduced in Mod 2 (22 s (Mod 1), 19 s (Mod 2); p &lt; 0.05), as was the "overshoot" in the normalized [HHb]/O2 uptake ratio (p &lt; 0.05).	Oxygen	32-34	chromobox 3	Homo sapiens	88-93
23644619-2	2013	This study investigated the effect of controlled oxygen reperfusion on receptor for advanced glycation end products (RAGE) expression and its downstream effects on lung ischemia-reperfusion injury.	Oxygen	49-55	advanced glycosylation end-product specific receptor	Canis lupus familiaris	117-121
23644619-7	2013	RAGE expression, TNF-alpha, and IL-6 were downregulated by controlled oxygen treatment (p &lt; 0.001).	Oxygen	70-76	advanced glycosylation end-product specific receptor	Canis lupus familiaris	0-4
23644619-8	2013	RAGE might be involved in the lung ischemia-reperfusion injury in canine model of CPB, which was downregulated by controlled oxygen reperfusion.	Oxygen	125-131	advanced glycosylation end-product specific receptor	Canis lupus familiaris	0-4
23656416-0	2013	Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer.	Oxygen	37-43	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	54-74
23656416-1	2013	We have previously shown that a cytochrome P450 (CYP450) hemoprotein from the 3A subfamily CYP3A13 for the mouse, serves as the sensor in the contraction of the ductus arteriosus in response to increased oxygen tension.	Oxygen	204-210	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	91-98
23656416-5	2013	Cyp3a13-transfected aortic cells responded to oxygen, whereas no significant response was seen in native cells or in cells transfected with an empty vector.	Oxygen	46-52	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	0-7
23656416-8	2013	We conclude that CYP3A13 is involved in oxygen sensing, and its action in the transfected muscle cells of the aorta, as in the native cells of the ductus, takes place through a linkage to ET-1.	Oxygen	40-46	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	17-24
23656416-9	2013	However, the response of aortic muscle to oxygen, conceivably entailing the presence of CYP3A13 at some special site, is not seen in the native situation, and may instead unfold upon transfection of the parent gene.	Oxygen	42-48	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	88-95
23416465-4	2013	Here we show that oxygen concentrations regulate mTORC1 activity in a highly dynamic manner.	Oxygen	18-24	CREB regulated transcription coactivator 1	Mus musculus	49-55
23416465-5	2013	The rapid response of mTORC1 to changes in oxygen concentrations was not mediated by the HIF transcription factor or its transcriptional targets, REDD1 and BNIP3.	Oxygen	43-49	CREB regulated transcription coactivator 1	Mus musculus	22-28
23416465-6	2013	Interestingly, we observed that the rapid response of mTORC1 activity to changes in oxygen concentrations is independent of transcription and new protein synthesis.	Oxygen	84-90	CREB regulated transcription coactivator 1	Mus musculus	54-60
23416465-9	2013	In conclusion, our results suggest that mTORC1 can respond rapidly to changes in oxygen concentrations via a post-translational mechanism that may involve a heme containing protein.	Oxygen	81-87	CREB regulated transcription coactivator 1	Mus musculus	40-46
22820117-4	2013	The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS.	Oxygen	113-119	superoxide dismutase 2	Homo sapiens	46-76
22820117-4	2013	The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS.	Oxygen	113-119	superoxide dismutase 2	Homo sapiens	78-83
23671427-4	2013	We show here that the molecular identity of both the BAG (O2/CO2-sensing) and the URX (O2-sensing) neurons is controlled by the phylogenetically conserved SoxD transcription factor homolog EGL-13.	Oxygen	62-64	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	189-195
23671427-8	2013	Finally, we found that EGL-13 is sufficient to induce O2- and CO2-sensing cell fates in some cellular contexts.	Oxygen	54-56	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	23-29
23671427-9	2013	Thus, the same core regulatory factor, egl-13, is required and sufficient to specify the distinct fates of O2- and CO2-sensing neurons in C. elegans.	Oxygen	107-109	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	39-45
23613849-6	2013	Finally, in cultures under 5% O2, more hTSCs expressed the stem cell markers nucleostemin, Oct-4, Nanog and SSEA-4.	Oxygen	30-32	G protein nucleolar 3	Homo sapiens	77-89
23380539-2	2013	Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor alpha (HIF-alpha) for von Hippel-Lindau protein-mediated proteasomal destruction.	Oxygen	104-110	egl-9 family hypoxia inducible factor 2	Homo sapiens	42-46
23429506-9	2013	PRX2 knockdown exacerbated neuronal death after oxygen and glucose deprivation.	Oxygen	48-54	peroxiredoxin 2	Mus musculus	0-4
23580319-4	2013	Only smoking cessation and oxygen therapy in COPD patients with hypoxemia reduce mortality.	Oxygen	27-33	COPD	Homo sapiens	45-49
23848893-4	2013	The newly discovered compound is formed in the stability fields of superionic ice and eta-O2, and has the same oxygen subnetwork as the latter.	Oxygen	90-92	endothelin receptor type A	Homo sapiens	86-89
23564640-5	2013	METHODS AND RESULTS: Studies of cultured ECs demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 mitogen-activated protein kinase-dependent transcriptional and post-transcriptional mechanisms.	Oxygen	75-81	mitogen-activated protein kinase 14	Mus musculus	103-106
23349297-7	2013	Angiopoietin-1 was correlated and Ang-2 was inversely related to a cardiac power index and mixed venous oxygen saturation, respectively (P &lt; 0.001 for all).	Oxygen	104-110	angiopoietin 2	Homo sapiens	34-39
23603279-7	2013	Notably, the amp1-1 lines exhibited higher expression levels of ABA-responsive genes (RAB18, RD29A and RD29B), higher concentration of proline and lower reactive oxygen species (ROS) levels (H2O2 and O2(-)) after ABA and dehydration treatments than those of wild type.	Oxygen	193-195	Peptidase M28 family protein	Arabidopsis thaliana	13-17
23282141-3	2013	A single in vitro exposure of ASCs to severe hypoxia (&lt;0.1% O2) significantly increased both the transcriptional and translational level of the vascular endothelial growth factor-A (VEGF-A) and angiogenin (ANG).	Oxygen	63-65	angiogenin	Homo sapiens	197-207
23282141-3	2013	A single in vitro exposure of ASCs to severe hypoxia (&lt;0.1% O2) significantly increased both the transcriptional and translational level of the vascular endothelial growth factor-A (VEGF-A) and angiogenin (ANG).	Oxygen	63-65	angiogenin	Homo sapiens	209-212
23667419-4	2013	In a murine central nervous system (CNS) GL261 glioma model, we visualized the impact of Pmel-1 cytotoxic T cell immunotherapy, delivered intravenously, on intracellular tumor oxygen levels.	Oxygen	176-182	premelanosome protein	Mus musculus	89-93
23349051-11	2013	Macrophages from ADORA2A(-/-) mice exposed to LPS plus oxygen expressed higher concentrations of proinflammatory cytokines and cosignaling molecules.	Oxygen	55-61	adenosine A2a receptor	Mus musculus	17-24
23349051-14	2013	ADORA2A is protective against lung injury after LPS and oxygen.	Oxygen	56-62	adenosine A2a receptor	Mus musculus	0-7
23349051-15	2013	Oxygen after LPS increases macrophage activation to augment lung injury by inhibiting the ADORA2A pathway.	Oxygen	0-6	adenosine A2a receptor	Mus musculus	90-97
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	105-107	cytochrome b-245, beta polypeptide	Mus musculus	221-225
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	105-107	cytochrome b-245, beta polypeptide	Mus musculus	244-248
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	163-169	cytochrome b-245, beta polypeptide	Mus musculus	221-225
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	163-169	cytochrome b-245, beta polypeptide	Mus musculus	244-248
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	173-175	cytochrome b-245, beta polypeptide	Mus musculus	221-225
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	173-175	cytochrome b-245, beta polypeptide	Mus musculus	244-248
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	173-175	cytochrome b-245, beta polypeptide	Mus musculus	221-225
23318789-3	2013	One of the immediate responses upon macrophage activation involves the production of superoxide radical (O2( -)) due to the NADPH-dependent univalent reduction of oxygen to O2( -) by the phagocytic NADPH oxidase isoform (NOX2), the activity of NOX2 being the main source of O2( -) in monocytes/macrophages.	Oxygen	173-175	cytochrome b-245, beta polypeptide	Mus musculus	244-248
23478801-13	2013	Therefore, we propose that Ngb controls HCC development by linking oxygen/ROS signals to oncogenic Raf/mitogen-activated protein kinase (MAPK)/Erk signaling.	Oxygen	67-73	zinc fingers and homeoboxes 2	Homo sapiens	99-102
23671427-0	2013	EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.	Oxygen	31-33	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	0-6
23671427-4	2013	We show here that the molecular identity of both the BAG (O2/CO2-sensing) and the URX (O2-sensing) neurons is controlled by the phylogenetically conserved SoxD transcription factor homolog EGL-13.	Oxygen	58-60	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	189-195
23498975-3	2013	Using fibroblasts from patients carrying three independent pathogenic mutations in the VCP gene, we show that VCP deficiency causes profound mitochondrial uncoupling leading to decreased mitochondrial membrane potential and increased mitochondrial oxygen consumption.	Oxygen	248-254	valosin containing protein	Homo sapiens	87-90
23313273-8	2013	In amino substituted molecules or in Acid Red 1 azo dye, O2 cannot compete efficiently with unimolecular transformation of organic radicals and the efficiency is lower (0.2-0.5).	Oxygen	57-59	adenosine deaminase RNA specific B1	Homo sapiens	42-47
23314043-6	2013	Not only did DPI and DTI decrease intracellular ROS, they both also significantly decreased the mRNA expression levels of Nox1, potentially contributing to the prolonged reduction in tumor cell reactive oxygen levels.	Oxygen	203-209	NADPH oxidase 1	Homo sapiens	122-126
23087050-6	2013	Here, we show that exposure to hyperoxia (&gt;= 99% O2) led to a significant elevation in concentrations of airway high mobility group box-1 (HMGB1) and increased mortality in C57BL/6 mice infected with PA.	Oxygen	52-54	high mobility group box 1	Mus musculus	115-140
23087050-6	2013	Here, we show that exposure to hyperoxia (&gt;= 99% O2) led to a significant elevation in concentrations of airway high mobility group box-1 (HMGB1) and increased mortality in C57BL/6 mice infected with PA.	Oxygen	52-54	high mobility group box 1	Mus musculus	142-147
23551103-7	2013	Thermogenesis and oxygen consumption are modulated by PI3Kgamma lipid kinase-dependent and -independent signaling mechanisms.	Oxygen	18-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	54-63
23305928-1	2013	P450(cin) (CYP176A) is a rare bacterial P450 in that contains an asparagine (Asn242) instead of the conserved threonine that almost all other P450s possess that directs oxygen activation by the heme prosthetic group.	Oxygen	169-175	pyridoxal phosphatase	Homo sapiens	0-9
23305928-2	2013	However, P450(cin) does have the neighbouring, conserved acid (Asp241) that is thought to be involved indirectly in the protonation of the dioxygen and affect the lifetime of the ferric-peroxo species produced during oxygen activation.	Oxygen	139-147	pyridoxal phosphatase	Homo sapiens	9-18
23305928-2	2013	However, P450(cin) does have the neighbouring, conserved acid (Asp241) that is thought to be involved indirectly in the protonation of the dioxygen and affect the lifetime of the ferric-peroxo species produced during oxygen activation.	Oxygen	141-147	pyridoxal phosphatase	Homo sapiens	9-18
23307067-2	2013	It has been applied to the data presented by Blok and Loman characterizing the oxygen effect in SSB and DSB formation (in water solution and at low-LET radiation) also in the region of very small oxygen concentrations, which cannot be studied with the help of experiments done with living cells.	Oxygen	79-85	small RNA binding exonuclease protection factor La	Homo sapiens	96-99
23307067-2	2013	It has been applied to the data presented by Blok and Loman characterizing the oxygen effect in SSB and DSB formation (in water solution and at low-LET radiation) also in the region of very small oxygen concentrations, which cannot be studied with the help of experiments done with living cells.	Oxygen	196-202	small RNA binding exonuclease protection factor La	Homo sapiens	96-99
23307067-4	2013	The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails.	Oxygen	42-48	small RNA binding exonuclease protection factor La	Homo sapiens	22-25
23307067-4	2013	The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails.	Oxygen	102-108	small RNA binding exonuclease protection factor La	Homo sapiens	22-25
23307067-4	2013	The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails.	Oxygen	102-108	small RNA binding exonuclease protection factor La	Homo sapiens	22-25
23307067-4	2013	The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails.	Oxygen	102-108	small RNA binding exonuclease protection factor La	Homo sapiens	22-25
23100171-10	2013	Similarly, the expressions of ATP-binding cassette protein A3 gene, a differentiation marker of AT II cells and of peroxiredoxin 6, thioredoxin and thioredoxin reductase, three genes involved in oxygen radical protection were increased.	Oxygen	195-201	peroxiredoxin 6	Homo sapiens	115-130
22991091-0	2013	Hyperbaric oxygen treatment prevents nitric oxide-induced apoptosis in articular cartilage injury via enhancement of the expression of heat shock protein 70.	Oxygen	11-17	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	135-156
23532072-6	2013	BSK1 physically associates with the PAMP receptor FLAGELLIN SENSING2 and is required for a subset of flg22-induced responses, including the reactive oxygen burst, but not for mitogen-activated protein kinase activation.	Oxygen	149-155	BR-signaling kinase 1	Arabidopsis thaliana	0-4
23356350-1	2013	Based on the V-shaped linker molecule 4,4"-benzophenonedicarboxylic acid, the new carbonyl-functionalized metal-organic framework (MOF) [Al(OH)(O(2)C-C(6)H(4)-CO-C(6)H(4)-CO(2))], denoted as CAU-8, was discovered employing high-throughput methods.	Oxygen	144-148	lysine acetyltransferase 8	Homo sapiens	106-135
23195625-1	2013	The mechanisms underlying subcellular oxygen transport mediated by myoglobin (Mb) remain unclear.	Oxygen	38-44	myoglobin	Rattus norvegicus	67-76
23195625-1	2013	The mechanisms underlying subcellular oxygen transport mediated by myoglobin (Mb) remain unclear.	Oxygen	38-44	myoglobin	Rattus norvegicus	78-80
23195625-2	2013	Recent evidence suggests that, in the myocardium, transverse diffusion of Mb is too slow to effectively supply oxygen to meet the immediate mitochondrial oxygen demands at the onset of muscle contractions.	Oxygen	111-117	myoglobin	Rattus norvegicus	74-76
23195625-2	2013	Recent evidence suggests that, in the myocardium, transverse diffusion of Mb is too slow to effectively supply oxygen to meet the immediate mitochondrial oxygen demands at the onset of muscle contractions.	Oxygen	154-160	myoglobin	Rattus norvegicus	74-76
23195625-3	2013	The cell may accommodate the demand by maintaining the distribution of Mb to ensure a sufficient O(2) supply in the immediate vicinity of the mitochondria.	Oxygen	97-101	myoglobin	Rattus norvegicus	71-73
23195625-8	2013	These results suggest that a direct Mb-mediated O2 delivery to the mitochondria, which may play a potentially significant role for respiration.	Oxygen	48-50	myoglobin	Rattus norvegicus	36-38
23022047-9	2013	DRG neurons derived from STZ-diabetic mice also exhibited deficiencies in maximal oxygen consumption rate and associated spare respiratory capacity that were corrected by exposure to CNTF for 24 h in an NF-kappaB-dependent manner.	Oxygen	82-88	ciliary neurotrophic factor	Mus musculus	183-187
23303788-0	2013	Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.	Oxygen	0-6	CXXC finger protein 5	Homo sapiens	123-128
23303788-0	2013	Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.	Oxygen	0-6	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	133-139
23303788-4	2013	We previously identified a highly conserved 13-bp sequence in the proximal promoter of COX4I2 that functions as an oxygen responsive element (ORE), maximally active at a 4% oxygen concentration.	Oxygen	115-121	cytochrome c oxidase subunit 4I2	Homo sapiens	87-93
23303788-4	2013	We previously identified a highly conserved 13-bp sequence in the proximal promoter of COX4I2 that functions as an oxygen responsive element (ORE), maximally active at a 4% oxygen concentration.	Oxygen	173-179	cytochrome c oxidase subunit 4I2	Homo sapiens	87-93
23303788-6	2013	We demonstrate that RBPJ and CHCHD2 function towards activating the ORE at 4% oxygen, whereas CXXC5 functions as an inhibitor.	Oxygen	78-84	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	29-35
23303788-8	2013	Depending on the oxygen tension, a concerted action of the three transcription factors regulates the expression of COX4I2 that, as we discuss, could augment both COX activity and its ability to cope with altered cellular energy requirements.	Oxygen	17-23	cytochrome c oxidase subunit 4I2	Homo sapiens	115-121
23303788-8	2013	Depending on the oxygen tension, a concerted action of the three transcription factors regulates the expression of COX4I2 that, as we discuss, could augment both COX activity and its ability to cope with altered cellular energy requirements.	Oxygen	17-23	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
23168577-5	2013	RESULTS: In CSF, S100 was higher with 90 s than with 30 or 60 s of initial positive-pressure ventilation, whereas concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were higher with 30 than with 60 s. Matrix metalloproteinase-2 (MMP-2) and intracellular adhesion molecule 1 (ICAM-1) were higher with 30 than with 60 s. No other comparison between ratios and oxygen concentrations used yielded significant results.	Oxygen	390-396	tumor necrosis factor	Sus scrofa	186-195
23364142-8	2013	Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO2, mmHg) (r = -0.387, p = 0.005).	Oxygen	64-70	chitinase 3 like 1	Homo sapiens	21-27
23445444-8	2013	XPS results indicated the increase of C O/C-O groups and decrease of C-Cl functionalities on the polymer surface after oxygen plasma treatment.	Oxygen	119-125	crystallin gamma C	Homo sapiens	69-73
23383688-1	2013	Time-resolved spectroscopy (TRS-20) measures tissue oxygen saturation (%) by evaluating the absolute concentrations of oxygenated, deoxygenated and total haemoglobin based on measurement of the transit time of individual photons through a tissue of interest.	Oxygen	52-58	trafficking protein particle complex subunit 2	Homo sapiens	28-34
23383688-2	2013	We measured tissue oxygen saturation in the prefrontal lobes of the brain by TRS-20 in eighteen pregnant women during caesarean section.	Oxygen	19-25	trafficking protein particle complex subunit 2	Homo sapiens	77-83
23383688-7	2013	TRS-20 could detect acute as well as chronic changes in brain oxygen saturation in response to pregnancy-associated complications.	Oxygen	62-68	trafficking protein particle complex subunit 2	Homo sapiens	0-6
25301994-9	2013	In future studies, we will confirm the effect of the oxygen microenvironment on NP uptake and efficacy of mNPHT both in vitro and in vivo.	Oxygen	53-59	laminin, beta 2	Mus musculus	106-111
23262083-8	2013	The expression of Hax-1 was also reduced in the cells subjected to oxygen/glucose deprivation (OGD) (p&lt;0.01).	Oxygen	67-73	HCLS1 associated X-1	Mus musculus	18-23
23011899-1	2013	The von Hippel-Lindau tumor suppressor protein (pVHL) plays a central role in the oxygen-sensing pathway by regulating the degradation of the hypoxia-inducible factor (HIF-1alpha).	Oxygen	82-88	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
23011899-2	2013	The capture of HIF-1alpha by pVHL is regulated by an oxygen-dependent hydroxylation of a specific conserved prolyl residue.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	29-33
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Oxygen	128-134	F-box and leucine-rich repeat protein 5	Mus musculus	72-77
23332757-2	2013	Using the yeast Saccharomyces cerevisiae, we report that SOD1 transmits signals from oxygen and glucose to repress respiration.	Oxygen	85-91	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	57-61
26660108-1	2016	The objective of this study is to elucidate the effect of a new glycogen synthase kinase-3beta (GSK-3beta) inhibitor in RA differentiated SH-SY5Y cells in oxygen and glucose deprivation (OGD) model.	Oxygen	155-161	glycogen synthase kinase 3 beta	Homo sapiens	64-94
23039043-1	2013	NO (nitric oxide) is described as an inhibitor of plant and mammalian respiratory chains owing to its high affinity for COX (cytochrome c oxidase), which hinders the reduction of oxygen to water.	Oxygen	179-185	cytochrome c oxidase subunit 8A	Homo sapiens	120-123
23505621-3	2013	The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of the UCP2 and UCP3 genes.	Oxygen	69-75	uncoupling protein 2	Homo sapiens	111-115
26660108-1	2016	The objective of this study is to elucidate the effect of a new glycogen synthase kinase-3beta (GSK-3beta) inhibitor in RA differentiated SH-SY5Y cells in oxygen and glucose deprivation (OGD) model.	Oxygen	155-161	glycogen synthase kinase 3 beta	Homo sapiens	96-105
27924625-8	2016	The temperature dependence results demonstrate that the N-SET1 behavior is dominated by Cu conductive filament (CF) reformation caused by the Cu CF overgrowth phenomenon while the N-SET2 is related to the formation of oxygen vacancy CF.	Oxygen	218-224	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	182-186
23833475-7	2013	CONCLUSIONS: The combination of three factors including polytrauma (with NISS &gt;17), serum lactate &gt;22 mmol/l at admission (within 12 hours of injury) fall in oxygen saturation (SaO2 below 90% in the initial 24 hours) predict the development of post-traumatic pulmonary complications, especially the fat embolism syndrome.	Oxygen	164-170	FAT atypical cadherin 1	Homo sapiens	305-308
23302636-8	2013	Plasma miR-210 levels may reflect a mismatch between the pump function of the heart and oxygen demand in the peripheral tissues, and be a new biomarker for chronic heart failure in addition to plasma BNP concentrations.	Oxygen	88-94	microRNA 210	Homo sapiens	7-14
27729406-7	2016	Finally, the reporter system reveals the role of elevated oxygen levels in eroding imprinted Dlk1 expression during prolonged culture and in vitro differentiation.	Oxygen	58-64	delta like non-canonical Notch ligand 1	Mus musculus	93-97
23206862-1	2013	Optimization of HTS hit 1 for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study.	Oxygen	169-175	neuropeptide Y receptor Y5	Mus musculus	30-45
23281416-3	2013	From this perspective, SNO-based signaling may have evolved as a major transducer of the cellular oxygen-sensing machinery that underlies global cardiovascular function.	Oxygen	98-104	strawberry notch homolog 1	Homo sapiens	23-26
23441123-7	2013	MiR-16 showed less stable expression with changes in oxygen levels and between strains compared to U6 snRNA.	Oxygen	53-59	microRNA 16	Rattus norvegicus	0-6
27559140-3	2016	We tested for the effects of alpha-cyano-4-hydroxycinnamic acid (4-CIN), which could interfere with energy metabolism by blocking monocarboxylate-transporter 2 (MCT2)-mediated neuronal lactate uptake, on evoked potentials, stimulus-induced changes in K+, Na+, Ca2+, and oxygen concentrations as well as on changes in flavin adenine dinucleotide (FAD) autofluorescence in the hippocampal area CA3.	Oxygen	270-276	pyridoxal phosphatase	Homo sapiens	67-70
22943955-7	2013	Here we demonstrate that severelow O(2) concentrations (1%) can function as a selective pressure for removing undifferentiated pluripotent cells during the induction of MSCs from rabbit ESCs (rESCs)  and that MSCs induced under severe hypoxic conditions function as normal MSCs; that is, they repopulate after cloning, express specific markers (vimentin, CD29, CD90, CD105, and CD140a) and differentiate into adipocytes, osteoblasts, and chondrocytes.	Oxygen	35-39	vimentin	Oryctolagus cuniculus	345-353
22967279-11	2013	One trial evaluated the effect of acupuncture on postexercise recovery and found that heart rate, oxygen consumption, and blood lactate were significantly reduced secondary to acupuncturing of PC 6 and ST 36 versus control and placebo conditions at 30 or 60 minutes postexercise.	Oxygen	98-104	proprotein convertase subtilisin/kexin type 5	Homo sapiens	193-197
24379900-2	2013	In this study, we characterized the involvement of NADPH oxidase (Nox), a multisubunit enzyme that catalyzes the reduction of oxygen, in the 6-hydroxydopamine- (6-OHDA-) induced PD mice model and compared for the first time the effects of this neurotoxin in mice lacking gp91(phox-/-), the catalytic subunit of Nox2, and pharmacological inhibition of Nox with apocynin.	Oxygen	126-132	cytochrome b-245, beta polypeptide	Mus musculus	311-315
23355903-7	2013	In differentiated THP-1 cells, lowering the oxygen tension to 5% O2 decreased phagocytic activity, the constitutive release of beta-hexosaminidase and LPS-induced NF-kappaB activation but enhanced LPS-stimulated release of cytokines.	Oxygen	44-50	O-GlcNAcase	Homo sapiens	127-146
23355903-7	2013	In differentiated THP-1 cells, lowering the oxygen tension to 5% O2 decreased phagocytic activity, the constitutive release of beta-hexosaminidase and LPS-induced NF-kappaB activation but enhanced LPS-stimulated release of cytokines.	Oxygen	65-67	O-GlcNAcase	Homo sapiens	127-146
27591124-8	2016	Notably, the impact of hypoxia vs normoxia on gene expression was modest and only a few genes (e.g., AK4, ALDOC, BNIP3P1, PGK1, and SLC2A1) were upregulated in EPDCs and CPCs after the cells were exposed to low oxygen for 24 h. Finally, we also performed a focused analysis of the gene expression patterns of a predefined set of 92 paracrine factors.	Oxygen	211-217	adenylate kinase 4	Homo sapiens	101-104
25474903-1	2013	We have shown that the decrease in oxygen tension in the culture medium of multipotent mesenchymal stromal cells (MMSCs) results in a short-term reduction in the proportion of CD73(+)-cells in the population, without effecting the number of cells expressing other constitutive surface markers (CD90 and CD105).	Oxygen	35-41	5'-nucleotidase ecto	Homo sapiens	176-180
23232974-9	2013	IGF-I reduced the apoptotic index in both oxygen conditions, but a significant decrease was detected in the 20 % O(2) group.	Oxygen	42-48	insulin-like growth factor 1	Mus musculus	0-5
23232974-9	2013	IGF-I reduced the apoptotic index in both oxygen conditions, but a significant decrease was detected in the 20 % O(2) group.	Oxygen	113-117	insulin-like growth factor 1	Mus musculus	0-5
23401655-11	2013	betaB2-crystallin showed the highest amount of O(2)-induced PSSG formation of any of the crystallins, as well as a substantial level of control PSSG, and nearly all of this was due to a single residue, C67, a site also present in human betaB2-crystallin.	Oxygen	47-51	crystallin beta B2	Homo sapiens	0-17
28774003-6	2016	Differences between the reduced and oxidized crystals are explained by their relative oxygen vacancy and free carrier concentrations which alter internal electric fields present at the Pt/Fe:STO interfaces.	Oxygen	86-92	nuclear receptor binding SET domain protein 1	Homo sapiens	191-194
23000503-3	2012	Attached and suspended biomasses, coupled to the high dissolved oxygen (DO), allow high removal efficiencies (90% and 56% for COD and N-NH(4)(+) removal respectively) and high effluent quality to be reached.	Oxygen	64-70	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	126-129
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Oxygen	104-110	LOC104968582	Bos taurus	0-12
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Oxygen	104-110	LOC104968582	Bos taurus	59-71
27693792-5	2016	Further, cIAP1-induced mitophagy led to dysfunctional mitochondria that resulted in abrogation of mitochondrial oxygen consumption rate along with the decrease in ATP levels.	Oxygen	112-118	baculoviral IAP repeat containing 2	Homo sapiens	9-14
23469658-6	2013	At 12 hours, the expression of occludin began to decrease with the prolonging of time and reduction of oxygen concentration (P &lt; 0.01).	Oxygen	103-109	occludin	Rattus norvegicus	31-39
23103253-6	2012	Our findings identify a link between the oxygen-sensing HIF2alpha pathway and mTORC1 regulation, revealing the molecular basis of the tumor-promoting properties of HIF2alpha in von Hippel-Lindau-deficient cells.	Oxygen	41-47	CREB regulated transcription coactivator 1	Mus musculus	78-84
27783918-0	2016	A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.	Oxygen	32-38	COPD	Homo sapiens	43-47
23103253-7	2012	We also describe relevant physiological scenarios, including those that occur in liver and lung tissue, wherein HIF2alpha or low-oxygen tension drive mTORC1 activity and SLC7A5 expression.	Oxygen	129-135	CREB regulated transcription coactivator 1	Mus musculus	150-156
22900669-1	2012	Fumarate reductase is an enzyme involved in maintaining redox balance through regeneration of reduced cofactors during oxygen deficiency conditions.	Oxygen	119-125	fumarate reductase	Saccharomyces cerevisiae S288C	0-18
23154460-8	2012	In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4(-/-) mice showed a significant increase in the unvascularized retinal area.	Oxygen	34-40	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	62-66
27783918-1	2016	BACKGROUND: Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation.	Oxygen	50-56	COPD	Homo sapiens	141-145
22452597-0	2012	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo (Bubalus bubalis) embryos affect mRNA expression of BCL-2, BCL-XL, MCL-1, BAX and BID.	Oxygen	0-6	bcl-2-like protein 1	Bubalus bubalis	149-155
27783918-2	2016	METHODS: We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%).	Oxygen	96-102	COPD	Homo sapiens	207-211
22452597-0	2012	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo (Bubalus bubalis) embryos affect mRNA expression of BCL-2, BCL-XL, MCL-1, BAX and BID.	Oxygen	0-6	apoptosis regulator BAX	Bubalus bubalis	164-167
27991963-2	2016	It is present in cytochromes, hemoglobin and myoglobin (Mb), where it binds to oxygen.	Oxygen	79-85	myoglobin	Rattus norvegicus	45-54
22452597-0	2012	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo (Bubalus bubalis) embryos affect mRNA expression of BCL-2, BCL-XL, MCL-1, BAX and BID.	Oxygen	0-6	BH3-interacting domain death agonist	Bubalus bubalis	172-175
23125837-5	2012	Previous investigations have revealed that Nox4 is involved in oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis.	Oxygen	63-69	NADPH oxidase 4	Homo sapiens	43-47
23151016-3	2012	A Co-/Fe-coordinating pyrolyzed polymer exhibited a high specific oxygen reduction activity with onset and half-wave potentials of 0.87 and 0.76 V vs RHE, respectively, in neutral media.	Oxygen	66-72	factor interacting with PAPOLA and CPSF1	Homo sapiens	150-153
23106300-2	2012	It is thought that decreasing oxygen tension enhances the complex regulation and phenotype of CD133 in glioma.	Oxygen	30-36	prominin 1	Homo sapiens	94-99
23065979-0	2012	ArcA and AppY antagonize IscR repression of hydrogenase-1 expression under anaerobic conditions, revealing a novel mode of O2 regulation of gene expression in Escherichia coli.	Oxygen	123-125	arginine deiminase	Escherichia coli	0-4
22524683-0	2012	Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?	Oxygen	71-77	F-box and WD repeat domain containing 8	Homo sapiens	13-19
27991963-2	2016	It is present in cytochromes, hemoglobin and myoglobin (Mb), where it binds to oxygen.	Oxygen	79-85	myoglobin	Rattus norvegicus	56-58
22687819-4	2012	Placental insulin/IGF-I signaling and fetal levels of oxygen, glucose and amino acids (AAs) are altered in pregnancy complications such as intrauterine growth restriction, and all these factors are well-established upstream regulators of mTORC1.	Oxygen	54-60	CREB regulated transcription coactivator 1	Mus musculus	238-244
23147506-2	2012	Previous reports showed that lowering oxygen tension induced an increase of BTSCs expressing CD133 and other stem cell-related genes and more pronounced clonogenic capacity in vitro.	Oxygen	38-44	prominin 1	Homo sapiens	93-98
23147506-4	2012	We confirmed that cultures exposed to lowered oxygen levels showed a severalfold increase of CD133-positive BTSCs.	Oxygen	46-52	prominin 1	Homo sapiens	93-98
27474953-1	2016	A hybrid (continuous-discrete) cascade control is proposed to regulate both, volatile fatty acids (VFA) and chemical oxygen demand (COD) concentrations in two-stage (acidogenic-methanogenic) anaerobic digestion (TSAD) processes.	Oxygen	117-123	SH2 domain containing 2A	Homo sapiens	212-216
23062787-2	2012	The results revealed that with the use of mixed culture acclimated to AO7 under anoxic/aerobic conditions, enhancement of the bioregeneration efficiency of AO7-loaded MAMS and the total removal efficiency of COD could be achieved when the bio-decolorization and bio-mineralization stages were fully aerated with dissolved oxygen above 7 mg/L.	Oxygen	322-328	ring finger protein 25	Homo sapiens	70-73
23062787-2	2012	The results revealed that with the use of mixed culture acclimated to AO7 under anoxic/aerobic conditions, enhancement of the bioregeneration efficiency of AO7-loaded MAMS and the total removal efficiency of COD could be achieved when the bio-decolorization and bio-mineralization stages were fully aerated with dissolved oxygen above 7 mg/L.	Oxygen	322-328	ring finger protein 25	Homo sapiens	156-159
23062787-2	2012	The results revealed that with the use of mixed culture acclimated to AO7 under anoxic/aerobic conditions, enhancement of the bioregeneration efficiency of AO7-loaded MAMS and the total removal efficiency of COD could be achieved when the bio-decolorization and bio-mineralization stages were fully aerated with dissolved oxygen above 7 mg/L.	Oxygen	322-328	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	208-211
27634844-0	2016	Retraction: Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2.	Oxygen	23-29	matrix metallopeptidase 2	Homo sapiens	184-210
23048035-8	2012	Here, we show that CTGF/CCN2 was dynamically expressed in the developing murine retinal vasculature and was abnormally increased and localized within neovascular tufts in the mouse eye with oxygen-induced retinopathy.	Oxygen	190-196	cellular communication network factor 2	Mus musculus	19-23
23048035-8	2012	Here, we show that CTGF/CCN2 was dynamically expressed in the developing murine retinal vasculature and was abnormally increased and localized within neovascular tufts in the mouse eye with oxygen-induced retinopathy.	Oxygen	190-196	cellular communication network factor 2	Mus musculus	24-28
27018995-2	2016	UNLABELLED: The evidence for tele-assistance (TA) in hypercapnic chronic obstructive pulmonary disease (COPD) patients on long-term oxygen therapy (LTOT) is scarce.	Oxygen	132-138	titin-cap	Homo sapiens	29-33
23203131-0	2012	Tenomodulin inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	68-74	tenomodulin	Mus musculus	0-11
27545759-6	2016	Therefore, this study demonstrates that the O2 concentration in the microenvironment differentially affects the repressive methylation on K27 and the activating methylation on K4 at the INK4a locus by inhibiting the H3K27me3 and H3K4me3 demethylases.	Oxygen	44-46	keratin 27	Homo sapiens	138-141
23203131-1	2012	We aimed to determine the anti-angiogenic effect of tenomodulin (TeM) on retinal neovascularization in an oxygen-induced retinopathy (OIR) mouse model.	Oxygen	106-112	tenomodulin	Mus musculus	52-63
27466199-7	2016	As a consequence, OXPHOS complexes and supercomplexes are partially disassembled in DISC1 knockdown cells, which suffer severe bioenergetic defects, evidenced by impaired oxygen consumption, adenosine triphosphate synthesis and mitochondrial membrane potential.	Oxygen	171-177	DISC1 scaffold protein	Homo sapiens	84-89
22575735-4	2012	Here, we tested the hypothesis that TK reduces cell injury induced by oxygen and glucose deprivation/reoxygenation (OGD/R) through activating Homer1b/c.	Oxygen	70-76	kallikrein 1	Homo sapiens	36-38
23178531-9	2012	Several cell lines were found to have an increased IRP1 basal activity at 20% O2 compared to 5% O2, which may lower HIF2alpha expression in some of the cell lines in a VHL-independent manner.	Oxygen	78-80	aconitase 1	Homo sapiens	51-55
27574022-0	2016	The emerging role of AMPK in the regulation of breathing and oxygen supply.	Oxygen	61-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	21-25
27574022-6	2016	It would appear, therefore, that evolutionary pressures have led to AMPK being utilized to regulate oxygen delivery and thus energy supply to the body in the short, medium and longer term.	Oxygen	100-106	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	68-72
23115192-4	2012	We further demonstrate that appoptosin induces reactive oxygen species release and intrinsic caspase-dependent apoptosis.	Oxygen	56-62	solute carrier family 25 member 38	Homo sapiens	28-38
27574022-9	2016	Allied to this, AMPK is critical to the control of hypoxic pulmonary vasoconstriction and thus ventilation-perfusion matching at the lungs and may also determine oxygen supply to the foetus by, for example, modulating utero-placental blood flow.	Oxygen	162-168	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	16-20
27574024-2	2016	Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply.	Oxygen	31-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	10-14
27574024-7	2016	review their recent work, which points to a pivotal role for AMPK in the transduction of cellular hypoxic stress to integrated ventilatory behaviour, critical in the defence of whole-body oxygen homoeostasis.	Oxygen	188-194	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	61-65
27574024-8	2016	Of great surprise, there is profound blunting of the hyperventilatory response to hypoxic stress in AMPK deficient mice, with resultant dysregulated breathing arising in spite of normal peripheral oxygen sensing and appropriate sensory input to the brain!	Oxygen	197-203	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	100-104
22948140-5	2012	Additionally, PDK1- and LDHA-overexpressing cells exhibited decreased oxygen consumption but maintained levels of ATP under both normal culture conditions and following Abeta treatment.	Oxygen	70-76	pyruvate dehydrogenase kinase 1	Rattus norvegicus	14-18
22948140-5	2012	Additionally, PDK1- and LDHA-overexpressing cells exhibited decreased oxygen consumption but maintained levels of ATP under both normal culture conditions and following Abeta treatment.	Oxygen	70-76	lactate dehydrogenase A	Rattus norvegicus	24-28
22985304-5	2012	In contrast, Xe(VIII) assumes a tetrahedral geometry when bound to four oxygen atoms.	Oxygen	72-78	cytochrome c oxidase subunit 8A	Homo sapiens	16-20
27337995-5	2016	P49/STRAP also reduced mitochondrial size, mitochondrial membrane potential and the mitochondrial oxygen consumption rate.	Oxygen	98-104	serine/threonine kinase receptor associated protein	Homo sapiens	4-9
22985304-6	2012	A theoretical comparison of the four-oxygen-bound Xe(IV) and Xe(VIII) species, based primarily on the density functional theory functional TPSS1KCIS, is presented herein.	Oxygen	37-43	cytochrome c oxidase subunit 8A	Homo sapiens	64-68
23067135-11	2012	CONCLUSIONS: In patients with Senning operation for d-TGA, peak VO2 and peak oxygen pulse decrease faster with age compared to healthy controls.	Oxygen	77-83	T-box transcription factor 1	Homo sapiens	54-57
22936665-4	2012	Low oxygen up-regulated inhibitor of DNA binding 2 (ID2) and suppressed Flt3-L-induced differentiation of bone marrow cells to pDCs in wild-type but not HIF-1alpha(fl/fl) LysM-Cre bone marrow cells.	Oxygen	4-10	inhibitor of DNA binding 2	Mus musculus	52-55
27581116-8	2016	Increased serum BNP levels were significantly associated with mean transcutaneous oxygen saturation (SpO2) (p&lt;0.0001), minimal SpO2 (p=0.002), oxygen desaturation index (p=0.001), and total sleep time spent with SpO2 lower than 90% (p=0.002).	Oxygen	82-88	natriuretic peptide B	Homo sapiens	16-19
22936665-4	2012	Low oxygen up-regulated inhibitor of DNA binding 2 (ID2) and suppressed Flt3-L-induced differentiation of bone marrow cells to pDCs in wild-type but not HIF-1alpha(fl/fl) LysM-Cre bone marrow cells.	Oxygen	4-10	FMS-like tyrosine kinase 3 ligand	Mus musculus	72-78
22822009-1	2012	Flavocytochrome b(558), the catalytic core of the phagocyte NADPH oxidase (NOX2), mediates electron transfer from NADPH to molecular oxygen to generate superoxide, the precursor of highly ROS for host defense.	Oxygen	133-139	cytochrome b-245, beta polypeptide	Mus musculus	75-79
27513520-15	2016	Furthermore, flap blood flow and partial pressure of oxygen in the Exp.	Oxygen	53-59	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	13-17
22922758-4	2012	Accordingly, expression of mutant LC3B with impaired ceramide binding, as predicted by molecular modeling, prevented CerS1-mediated mitochondrial targeting, recovering oxygen consumption.	Oxygen	168-174	microtubule associated protein 1 light chain 3 beta	Homo sapiens	34-38
27235555-0	2016	Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.	Oxygen	48-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	20-44
22840297-12	2012	Cells transfected with pre-miR-210 showed significant reduction in oxygen consumption.	Oxygen	67-73	microRNA 210	Homo sapiens	27-34
27235555-5	2016	The role of CYP1B1 in oxygen-mediated pulmonary toxicity has not been studied.	Oxygen	22-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-18
27235555-6	2016	In this investigation, we tested the hypothesis that CYP1B1 plays a mechanistic role in oxygen toxicity in pulmonary cells in vitro.	Oxygen	88-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	53-59
27235555-13	2016	In conclusion, our results support the hypothesis that CYP1B1 plays a mechanistic role in pulmonary oxygen toxicity, and CYP1B1-mediated apoptosis could be one of the mechanisms of oxygen toxicity.	Oxygen	100-106	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	55-61
27494181-7	2016	The siRNA that resulted in the greatest change in cellular oxygen consumption was targeting the KCNN4 gene, which encodes for the Ca2+-sensitive K+ channel KCa3.1.	Oxygen	59-65	potassium calcium-activated channel subfamily N member 4	Homo sapiens	96-101
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Oxygen	108-114	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
27494181-7	2016	The siRNA that resulted in the greatest change in cellular oxygen consumption was targeting the KCNN4 gene, which encodes for the Ca2+-sensitive K+ channel KCa3.1.	Oxygen	59-65	potassium calcium-activated channel subfamily N member 4	Homo sapiens	156-162
22685026-4	2012	Immediate postoperative BNP correlated with preoperative haematocrit (rho = 0.52, P = 0.03) and inversely with preoperative oxygen saturation (rho = -0.63, P = 0.007).	Oxygen	124-130	natriuretic peptide B	Homo sapiens	24-27
27400679-4	2016	The as-prepared three-dimensional oxygen evolution electrode exhibits a small overpotential of 255 mV at 35 mA cm(-2) and a low Tafel slope of 47.2 mV dec(-1) and keeps high stability during a 28 h measurement in alkaline solution.	Oxygen	34-40	deleted in esophageal cancer 1	Homo sapiens	151-157
22685026-6	2012	Subsequent BNP expression (post-op day 1) correlated with a low RV fractional area change (rho = -0.51, P = 0.04), high oxygen extraction ratio (rho = 0.56, P = 0.02) and high central venous pressure (rho = 0.79, P &lt; 0.001).	Oxygen	120-126	natriuretic peptide B	Homo sapiens	11-14
27155083-0	2016	Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis.	Oxygen	14-20	cellular communication network factor 2	Homo sapiens	138-142
22552886-3	2012	Additionally, CK2 inhibitors significantly reduced retinal neovascularization and stem cell recruitment in the mouse model of oxygen-induced proliferative retinopathy.	Oxygen	126-132	casein kinase 2, alpha prime polypeptide	Mus musculus	14-17
27259535-1	2016	The AMP-activated protein kinase (AMPK) and hypoxia-inducible factor (HIF) signaling pathways are evolutionarily-conserved survival mechanisms responding to two fundamental stresses, energy deficiency and/or oxygen deprivation.	Oxygen	208-214	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	4-32
22859693-4	2012	Mutations in the frataxin gene impair mitochondrial function, increase reactive oxygen species, and trigger redistribution of iron in the mitochondria and cytosol.	Oxygen	80-86	frataxin	Homo sapiens	17-25
27259535-1	2016	The AMP-activated protein kinase (AMPK) and hypoxia-inducible factor (HIF) signaling pathways are evolutionarily-conserved survival mechanisms responding to two fundamental stresses, energy deficiency and/or oxygen deprivation.	Oxygen	208-214	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	34-38
27240426-1	2016	Hb Tarrant [alpha126(H9)Asp Asn; HBA2: c.379G &gt; A (or HBA1)], is a rare high oxygen affinity hemoglobin (Hb) variant that causes erythrocytosis, previously described in a few Mexican-American families.	Oxygen	80-86	hemoglobin subunit alpha 1	Homo sapiens	57-61
22753548-2	2012	At the cellular level it is unclear whether the suppression of cardiac Ca(2+) channels (Ca(V)1.2) results directly from oxygen deprivation on the channel protein or is mediated by intermediary proteins affecting the channel.	Oxygen	120-126	immunoglobulin lambda variable 2-8	Homo sapiens	88-96
27494343-0	2016	CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.	Oxygen	92-98	ciliary neurotrophic factor	Mus musculus	0-4
22824424-1	2012	Manganese-stabilizing protein (MSP) represents a key component of the oxygen-evolving complex (OEC).	Oxygen	70-76	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	0-29
22824424-1	2012	Manganese-stabilizing protein (MSP) represents a key component of the oxygen-evolving complex (OEC).	Oxygen	70-76	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	31-34
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	4-10	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	102-105
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	4-10	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	4-10	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	102-105
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	102-105
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-5	2012	The oxygen measurements indicated that the relative oxygen evolution was directly proportional to the MSP expression, as MSP-antisense plants showed much lower oxygen evolution compared to MSP-sense as well as UT plants.	Oxygen	52-58	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	121-124
22824424-7	2012	Chlorophyll a fluorescence analyses indicate a possible lack of intact Oxygen Evolving Complexes (OECs) in MSP antisense plants, which allow access to internal non-water electron donors (e.g., ascorbate and proline) and consequently increase the Photosystem II (PSII) activity of those plants.	Oxygen	71-77	oxygen-evolving enhancer protein 1, chloroplastic	Solanum tuberosum	107-110
27105554-8	2016	In addition, TCDD altered cellular respiration in an AHR-dependent manner to maintain respiratory efficiency as measured by oxygen consumption rate (OCR).	Oxygen	124-130	aryl hydrocarbon receptor	Homo sapiens	53-56
22674391-6	2012	Moreover, human extravillous trophoblast cells exposed to 1% oxygen demonstrated increased expression of transforming growth factor-beta3 (TGFB3), and recombinant human TGFB3 inhibited the invasion of human extravillous trophoblast cells in a dose-dependent manner.	Oxygen	61-67	transforming growth factor beta 3	Homo sapiens	105-137
22674391-6	2012	Moreover, human extravillous trophoblast cells exposed to 1% oxygen demonstrated increased expression of transforming growth factor-beta3 (TGFB3), and recombinant human TGFB3 inhibited the invasion of human extravillous trophoblast cells in a dose-dependent manner.	Oxygen	61-67	transforming growth factor beta 3	Homo sapiens	139-144
22917272-4	2012	In support of the regulation of COX Vb expression by the Ras family, we also found that selective siRNA-mediated inhibition of K-Ras expression in A549 lung adenocarcinoma cells reduced COX Vb protein expression, COX activity, oxygen consumption and the steady-state concentration of ATP.	Oxygen	227-233	cytochrome c oxidase subunit 5B	Homo sapiens	32-38
22917272-4	2012	In support of the regulation of COX Vb expression by the Ras family, we also found that selective siRNA-mediated inhibition of K-Ras expression in A549 lung adenocarcinoma cells reduced COX Vb protein expression, COX activity, oxygen consumption and the steady-state concentration of ATP.	Oxygen	227-233	cytochrome c oxidase subunit 8A	Homo sapiens	32-35
22917272-6	2012	We transfected the A549 cells with COX Vb small interfering or shRNA and observed a significant reduction of their COX activity, oxygen consumption, ATP and ability to grow in soft agar and as poorly differentiated tumors in athymic mice.	Oxygen	129-135	cytochrome c oxidase subunit 5B	Homo sapiens	35-41
22777010-5	2012	Furthermore, the distribution and coordination of oxygen atoms at the interface of alpha-Fe(2)O(3)-SnO(2) heterostructure are analyzed, which reveals that only slight deviations from their original equilibrium positions are allowed for the formation of heterogeneous interface.	Oxygen	50-56	strawberry notch homolog 1	Homo sapiens	99-102
22934072-7	2012	Anoxia induced by O(2)-glucose deprivation and severe hypoxia (1% O(2)) activates TRPM7 and TRPC6, respectively, whereas TRPA1 has recently been identified as a novel sensor of hyperoxia and mild hypoxia (15% O(2)) in vagal and sensory neurons.	Oxygen	18-22	transient receptor potential cation channel subfamily C member 6	Homo sapiens	92-97
22934072-7	2012	Anoxia induced by O(2)-glucose deprivation and severe hypoxia (1% O(2)) activates TRPM7 and TRPC6, respectively, whereas TRPA1 has recently been identified as a novel sensor of hyperoxia and mild hypoxia (15% O(2)) in vagal and sensory neurons.	Oxygen	66-71	transient receptor potential cation channel subfamily C member 6	Homo sapiens	92-97
25624795-0	2012	Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury.	Oxygen	17-23	aquaporin-4	Oryctolagus cuniculus	41-52
25624795-4	2012	These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.	Oxygen	46-52	aquaporin-4	Oryctolagus cuniculus	126-137
22659882-8	2012	Both alveolar-arterial oxygen difference and protein levels in bronchoalveolar lavage were lower in mice treated with anti-miR-21 than in mice treated with pre-miR-21 or negative-control miRNA (D(A-a): 66 +- 27 vs. 131 +- 22, 144 +- 10 mmHg, respectively, P &lt; 0.001; protein concentration: 1.1 +- 0.2 vs. 2.3 +- 1, 2.1 +- 0.4 mg/ml, respectively, P &lt; 0.01).	Oxygen	23-29	microRNA 21a	Mus musculus	123-129
22718803-1	2012	Maternally derived inflammatory mediators, such as IL-6 and IL-8, contribute to preterm delivery, low birth weight, and respiratory insufficiency, which are routinely treated with oxygen.	Oxygen	180-186	chemokine (C-X-C motif) ligand 15	Mus musculus	60-64
22609621-5	2012	Over-expression of microRNA-203 increased the tolerance of B35 cells to oxygen-glucose deprivation and the expression of phospho-Akt, a protein kinase that promotes cell survival.	Oxygen	72-78	microRNA 203	Rattus norvegicus	19-31
22555438-10	2012	In metabolic cage studies, lean Aldh1a1-deficient mice manifested enhanced oxygen consumption and reduced respiratory quotient vs. WT controls, consistent with increased expression of fatty acid oxidation markers in skeletal muscle.	Oxygen	75-81	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	32-39
23282708-5	2012	Some of the phenotypes detected are COPD with chronic respiratory failure and responsive to home oxygen therapy, COPD with upper lobe emphysema and responsive to volume reduction surgery, COPD with frequent exacerbation behavior, COPD resembling bronchitis and responsive to Roflumilast and possibly, COPD with systemic involvement.	Oxygen	97-103	COPD	Homo sapiens	36-40
22521791-5	2012	The presented results show that the Hb dimer in the Hb-Hp complex has oxygen binding, CO recombination and spectroscopic properties consistent with an Hb species having properties similar to but not exactly the same as the R quaternary state of the Hb tetramer.	Oxygen	70-76	hemoglobin subunit alpha 1	Homo sapiens	52-57
22534786-3	2012	With respect to brain slices, microfluidic technology may 1) overcome the traditional limitations of conventional interface and submerged slice chambers and improve oxygen/nutrient penetration into slices, 2) provide better spatiotemporal control over solution flow/drug delivery to specific slice regions, and 3) permit successful integration with modern optical and electrophysiological techniques.	Oxygen	165-171	protein kinase C delta	Homo sapiens	54-59
22562152-3	2012	Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism.	Oxygen	89-95	von Hippel-Lindau tumor suppressor	Homo sapiens	248-252
22562152-3	2012	Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism.	Oxygen	136-142	von Hippel-Lindau tumor suppressor	Homo sapiens	248-252
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Oxygen	184-191	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Oxygen	184-191	MHC class I polypeptide-related sequence A	Homo sapiens	199-203
21875341-2	2012	Current differentiation strategies rely on exposing pluripotent stem cells to soluble growth factors that play key roles during early development (such as DKK-1, Noggin, and IGF-1) at 20% oxygen (O(2)).	Oxygen	196-200	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	155-160
21875341-2	2012	Current differentiation strategies rely on exposing pluripotent stem cells to soluble growth factors that play key roles during early development (such as DKK-1, Noggin, and IGF-1) at 20% oxygen (O(2)).	Oxygen	196-200	noggin	Homo sapiens	162-168
22596227-4	2012	We also present protocol modifications needed for efficient recovery of MEF clones expressing p53 constructs that retain wild-type function, including growth at low (3%) oxygen and transient downregulation of p53 regulators to forestall cell senescence of primary MEFs.	Oxygen	170-176	E74-like factor 4 (ets domain transcription factor)	Mus musculus	72-75
22431727-9	2012	The abundance of LHCBM1 and LHCBM2/7 is in both cases correlated with resistance to superoxide anion, whereas only LHCBM1 is also involved in singlet oxygen scavenging.	Oxygen	150-156	uncharacterized protein	Chlamydomonas reinhardtii	115-121
22655590-9	2012	The mice injected with FGF-2/F/P MPs also recovered hindlimb blood flow, as reflected by oxygen saturation and surface temperature evaluation.	Oxygen	89-95	fibroblast growth factor 2	Mus musculus	23-28
22965464-0	2012	[Pd(NHC)(PR3)] (NHC = N-heterocyclic carbene) catalysed alcohol oxidation using molecular oxygen.	Oxygen	90-96	proteinase 3	Homo sapiens	9-12
22864183-10	2012	The specific function of neuroglobin that conveys hypoxia tolerance may either relate to oxygen supply or protection from reactive oxygen species.	Oxygen	89-95	neuroglobin	Bos taurus	25-36
23025234-1	2012	In this paper, SnO(x) films were produced by reactive radio frequency magnetron sputtering under various oxygen partial pressure (P(O)) in conjunction with a thermal annealing at 200  C afterwards.	Oxygen	105-111	strawberry notch homolog 1	Homo sapiens	15-18
22988108-9	2012	These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability.	Oxygen	203-209	forkhead box P3	Homo sapiens	83-88
22505034-7	2012	Given that atmospheric oxygen is thought to play a role in the differentiation and maintenance of various ocular cell types, our results suggest that Sema3A-PlxA signalling activated by an effect of ambient oxygen on PlxA expression may contribute to differentiation of the retinal pigment epithelium.	Oxygen	23-29	semaphorin 3A	Homo sapiens	150-156
22505034-7	2012	Given that atmospheric oxygen is thought to play a role in the differentiation and maintenance of various ocular cell types, our results suggest that Sema3A-PlxA signalling activated by an effect of ambient oxygen on PlxA expression may contribute to differentiation of the retinal pigment epithelium.	Oxygen	207-213	semaphorin 3A	Homo sapiens	150-156
22884536-0	2012	Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl/6N mice.	Oxygen	53-59	neuropeptide Y	Mus musculus	31-45
22884536-1	2012	In this study, we investigated whether the proangiogenic neuropeptides secretoneurin (SN), substance P (SP), and neuropeptide Y (NPY) contribute to the development of abnormal neovascularization in the oxygen-induced retinopathy (OIR) model in mice.	Oxygen	202-208	neuropeptide Y	Mus musculus	113-127
22884536-1	2012	In this study, we investigated whether the proangiogenic neuropeptides secretoneurin (SN), substance P (SP), and neuropeptide Y (NPY) contribute to the development of abnormal neovascularization in the oxygen-induced retinopathy (OIR) model in mice.	Oxygen	202-208	neuropeptide Y	Mus musculus	129-132
22887998-4	2012	We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell death induced by glucose and oxygen restriction.	Oxygen	139-145	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	20-25
22887998-4	2012	We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell death induced by glucose and oxygen restriction.	Oxygen	139-145	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	91-96
23147045-0	2012	Muscle strength as a determinant of oxygen uptake efficiency and maximal metabolic response in patients with mild-to-moderate COPD.	Oxygen	36-42	COPD	Homo sapiens	126-130
22128786-0	2012	Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes.	Oxygen	37-43	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	76-80
22708893-4	2012	MPP(+) caused a dose-dependent decrease in the basal oxygen consumption rate in dopaminergic N27 cells, indicating a loss of mitochondrial function.	Oxygen	53-59	M-phase phosphoprotein 6	Homo sapiens	0-3
22708893-7	2012	In addition, the extracellular acidification rate, used as a marker of glycolysis, was stimulated to compensate for oxygen consumption rate inhibition after exposure to MPP(+), rotenone, or 6-OHDA, but not paraquat.	Oxygen	116-122	M-phase phosphoprotein 6	Homo sapiens	169-172
27249784-1	2016	A chromium(II)-based metal-organic framework Cr3 [(Cr4 Cl)3 (BTT)8 ]2 (Cr-BTT; BTT(3-) =1,3,5-benzenetristetrazolate), featuring coordinatively unsaturated, redox-active Cr(2+) cation sites, was synthesized and investigated for potential applications in H2 storage and O2 production.	Oxygen	269-271	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	45-48
27525851-2	2016	The cultured neurons were exposed to 1% O2 and the expression of AMPA receptor subunit GluR2 on the cell surface was significantly increased, while total GluR2 was not markedly changed.	Oxygen	40-42	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	87-92
27199445-11	2016	Conversely, overexpression of JMJD8 enhanced cellular oxygen consumption rate of ECs, reflecting an increased mitochondrial respiration.	Oxygen	54-60	jumonji domain containing 8	Mus musculus	30-35
27039902-8	2016	In isolated mouse islets and MIN6 cells, O2 deprivation (1-5% vs 20%; 4-24 h) markedly reduced the expression of adaptive UPR genes, including Hspa5, Hsp90b1, Fkbp11 and spliced Xbp1.	Oxygen	41-43	heat shock protein 90, beta (Grp94), member 1	Mus musculus	150-157
26798996-2	2016	In this study, a refined method to determine the specific activity of a single quinol oxidase is exemplarily described for the alternative oxidase (AOX) isoform AOX1A from Arabidopsis thaliana and its corresponding mutants, using the respiratory chain of an Escherichia coli cytochrome bo and bd-I oxidase double mutant as a source to provide electrons necessary for O2 reduction via quinol oxidases.	Oxygen	367-369	alternative oxidase 2	Arabidopsis thaliana	127-146
26798996-2	2016	In this study, a refined method to determine the specific activity of a single quinol oxidase is exemplarily described for the alternative oxidase (AOX) isoform AOX1A from Arabidopsis thaliana and its corresponding mutants, using the respiratory chain of an Escherichia coli cytochrome bo and bd-I oxidase double mutant as a source to provide electrons necessary for O2 reduction via quinol oxidases.	Oxygen	367-369	alternative oxidase 2	Arabidopsis thaliana	148-151
26798996-2	2016	In this study, a refined method to determine the specific activity of a single quinol oxidase is exemplarily described for the alternative oxidase (AOX) isoform AOX1A from Arabidopsis thaliana and its corresponding mutants, using the respiratory chain of an Escherichia coli cytochrome bo and bd-I oxidase double mutant as a source to provide electrons necessary for O2 reduction via quinol oxidases.	Oxygen	367-369	alternative oxidase 1A	Arabidopsis thaliana	161-166
26903530-7	2016	However, under conditions where photorespiration was suppressed by high CO2 or low O2 levels, the decline in Fv/Fm was suppressed in the aox1a mutants, but not in the wild type, making the difference between the wild type and mutants small.	Oxygen	73-75	alternative oxidase 1A	Arabidopsis thaliana	137-142
26800298-11	2016	In addition, our MD simulations exhibit additional strong hydrogen bond networks between the protein and PLP: the phosphate group is held in place by the donation of at least three hydrogen bonds while the carbonyl oxygen of the pyridine ring interacts with Gln301; Phe181 forms a pi-pi stacking interaction with the pyridine ring and works as a gate keeper with the assistance of Val300.	Oxygen	215-221	pyridoxal phosphatase	Homo sapiens	105-108
27322969-0	2016	Science to Practice: Can MR Imaging-derived Oxygen-Hemoglobin Dissociation Curves Reveal Transplacental Oxygen Transport and Thus Aid in Monitoring Placental Function?	Oxygen	44-50	activation induced cytidine deaminase	Homo sapiens	130-133
22913590-9	2012	Equine MSCs expressed the embryonic markers NANOG, OCT4 and SOX2 in both oxygen conditions.	Oxygen	73-79	homeobox protein NANOG	Equus caballus	44-49
27241919-0	2016	The charge states of Au on gold-substituted Ce1-xO2(111) surfaces with multiple oxygen vacancies.	Oxygen	80-86	carboxylesterase 1	Homo sapiens	44-47
22820193-1	2012	Neuroglobin (Ngb), a neuronal specific oxygen binding heme-globin, reported to be expressed at high levels in most layers of the murine retina.	Oxygen	39-45	neuroglobin	Mus musculus	0-11
22820193-1	2012	Neuroglobin (Ngb), a neuronal specific oxygen binding heme-globin, reported to be expressed at high levels in most layers of the murine retina.	Oxygen	39-45	neuroglobin	Mus musculus	13-16
21927832-10	2012	The higher VO(2) for INT 2 versus INT 1 and similar DeltaHHb during INT suggests an increase in oxygen delivery during INT 2.	Oxygen	96-102	fibroblast growth factor 3	Homo sapiens	21-26
21927832-10	2012	The higher VO(2) for INT 2 versus INT 1 and similar DeltaHHb during INT suggests an increase in oxygen delivery during INT 2.	Oxygen	96-102	fibroblast growth factor 3	Homo sapiens	119-124
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	80-86	neuroglobin	Mus musculus	0-3
27297042-0	2016	TLR2/4 deficiency prevents oxygen-induced vascular degeneration and promotes revascularization by downregulating IL-17 in the retina.	Oxygen	27-33	toll-like receptor 2	Mus musculus	0-6
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	80-86	neuroglobin	Mus musculus	108-111
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	143-149	neuroglobin	Mus musculus	0-3
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	143-149	neuroglobin	Mus musculus	108-111
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	143-149	neuroglobin	Mus musculus	0-3
22820193-2	2012	Ngb"s function is presently unknown, but based on its high expression level and oxygen binding capabilities Ngb was proposed to function as an oxygen reservoir facilitating oxygen metabolism in highly active neurons or to function as a neuroprotectant.	Oxygen	143-149	neuroglobin	Mus musculus	108-111
22127737-8	2012	Homology modeling identified a residue specific to ASPGB1, Phe(162), preceding the variable loop, whose side chain is located in proximity to the beta-carboxylate group of the product aspartate, and to Gly(246), a residue participating in an oxyanion hole which stabilizes a negative charge forming on the side chain oxygen of asparagine during catalysis.	Oxygen	317-323	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	51-57
27297042-3	2016	Here, we show that Toll-like receptor 2 and 4 (TLR2/4) double deficiency suppressed hyperoxia induced retinal vessel regression in an oxygen-induced retinopathy (OIR) model.	Oxygen	134-140	toll-like receptor 2	Mus musculus	19-45
22429651-4	2012	COPD severity was quantified by: FEV(1) and COPD Severity Score, which incorporates COPD symptoms, requirement for COPD medications and oxygen, and hospital-based utilization.	Oxygen	136-142	COPD	Homo sapiens	0-4
26286401-2	2012	This radical is found to undergo a remarkably rapid reaction with O2 to form the hydroperoxyl radical (HO2( )) and an even-electron imine (NHCHCO2(-)), with experiments and master equation simulations revealing that reaction proceeds at the ion-molecule collision rate.	Oxygen	66-68	heme oxygenase 2	Homo sapiens	103-106
22789427-2	2012	Stabilization of a key regulator termed the hypoxia inducible factor (HIF)-1alpha under oxygen deficient environment around tumor is known to elicit expression of VEGF through binding to p300.	Oxygen	88-94	E1A binding protein p300	Homo sapiens	187-191
27297042-3	2016	Here, we show that Toll-like receptor 2 and 4 (TLR2/4) double deficiency suppressed hyperoxia induced retinal vessel regression in an oxygen-induced retinopathy (OIR) model.	Oxygen	134-140	toll-like receptor 2	Mus musculus	47-53
22611085-3	2012	Biochemical characterization and histological analysis showed close association of CCN2/CTGF with these regulators in murine angiogenesis models: normal retinal development, oxygen-induced retinopathy (OIR), and Lewis lung carcinomas.	Oxygen	174-180	cellular communication network factor 2	Mus musculus	83-87
27105921-1	2016	An actinyl peroxide cage cluster, Li48+m K12 (OH)m [UO2 (O2 )(OH)]60 (H2 O)n (m 20 and n 310; U60 ), discriminates precisely between Na(+) and K(+) ions when heated to certain temperatures, a most essential feature for K(+) selective filters.	Oxygen	53-55	small nucleolar RNA, C/D box 60	Homo sapiens	94-97
22611085-3	2012	Biochemical characterization and histological analysis showed close association of CCN2/CTGF with these regulators in murine angiogenesis models: normal retinal development, oxygen-induced retinopathy (OIR), and Lewis lung carcinomas.	Oxygen	174-180	cellular communication network factor 2	Mus musculus	88-92
22286776-8	2012	Under both oxygen tensions, Hsp90 inhibition downregulated the cell cycle-associated proteins, Cdk1, Cdk4 and pRb.	Oxygen	11-17	RB transcriptional corepressor 1	Homo sapiens	110-113
27080394-12	2016	In conclusion, ANT1 overexpression compensates impaired ANT activity under oxygen-restricted conditions.	Oxygen	75-81	solute carrier family 25 member 4	Rattus norvegicus	15-19
22134773-0	2012	In vitro expansion of human glioblastoma cells at non-physiological             oxygen tension irreversibly alters subsequent in vivo aggressiveness and AC133             expression.	Oxygen	80-86	prominin 1	Homo sapiens	153-158
22134773-2	2012	Recently, it was demonstrated             that increasing oxygen tension (pO2) down-regulated AC133 expression in glioblastoma             cells in vitro.	Oxygen	58-64	prominin 1	Homo sapiens	94-99
22395314-3	2012	Three HIF prolyl hydroxylase enzymes (PHD1, PHD2 and PHD3) function as oxygen sensing enzymes, which regulate the activity of HIFs in normoxic and hypoxic conditions.	Oxygen	71-77	egl-9 family hypoxia inducible factor 2	Homo sapiens	38-42
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	peroxisome proliferator activated receptor gamma	Mus musculus	176-186
22870390-8	2012	One of these transcripts, ndh, encodes a major component of the aerobic respiratory chain and is regulated by oxygen-responsive TFs ArcA and FNR.	Oxygen	110-116	arginine deiminase	Escherichia coli	132-136
27303300-8	2016	The results suggest that either PACAP or VIP exert an anti-infiltrative effect under low oxygen tension by modulating HIFs and EGFR expression, key elements involved in cell migration and angiogenesis.	Oxygen	89-95	adenylate cyclase activating polypeptide 1	Homo sapiens	32-37
22372402-6	2012	Complex 2 was applied in the catalytic epoxidation of the biorenewable olefins DL-limonene (Lim) and methyl oleate (Ole), using tert-butylhydroperoxide (TBHP) as an oxygen donor, under mild reaction conditions (55  C, air).	Oxygen	165-171	PDZ and LIM domain 5	Homo sapiens	92-95
27198227-5	2016	Loss of GRSF1 lowered the mitochondrial levels of RMRP, in turn suppressing oxygen consumption rates and modestly reducing mitochondrial DNA replication priming.	Oxygen	76-82	RNA component of mitochondrial RNA processing endoribonuclease	Homo sapiens	50-54
26105334-14	2012	This finding may directly correlate with the reported ability of angiogenin inhibitor to protect from oxidative stress by its reactivity as an oxygen species scavenger.	Oxygen	143-149	angiogenin	Homo sapiens	65-75
22365688-4	2012	Therefore, such an efficient platform was developed to fabricate mediator-free oxygen sensor and glucose biosensor based on glucose dehydrogenase (GDH).	Oxygen	79-85	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	147-150
27109550-5	2016	Ni4(PET)8 are slightly better catalysts than Ni6(PET)12 which initiate oxygen evolution at an amazingly low overpotential of ~1.51 V (vs. RHE; eta  280 mV).	Oxygen	71-77	factor interacting with PAPOLA and CPSF1	Homo sapiens	138-141
22304481-0	2012	Theoretical determination of the rate coefficient for the HO2 + HO2   H2O2+O2 reaction: adiabatic treatment of anharmonic torsional effects.	Oxygen	59-61	heme oxygenase 2	Homo sapiens	64-67
22020327-6	2012	When the cells were cultivated in 5% oxygen, RAF1 activation generated minimal reactive oxygen species, but RAF-induced senescence occurred efficiently in these conditions even in the presence of anti-oxidants or inhibitors of DNA checkpoint pathways.	Oxygen	37-43	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	45-49
22020327-6	2012	When the cells were cultivated in 5% oxygen, RAF1 activation generated minimal reactive oxygen species, but RAF-induced senescence occurred efficiently in these conditions even in the presence of anti-oxidants or inhibitors of DNA checkpoint pathways.	Oxygen	37-43	zinc fingers and homeoboxes 2	Homo sapiens	45-48
27109550-6	2016	The peak oxygen evolution current density (J) of ~150 mA cm(-2) at 2.0 V (vs. RHE) with a Tafel slope of 38 mV dec(-1) is observed using Ni4(PET)8.	Oxygen	9-15	factor interacting with PAPOLA and CPSF1	Homo sapiens	78-81
22532294-7	2012	Concerted coordination of acetophenone and dual hydrogen-atom transfer from the PNP arm and the coordinated ethanol to, respectively, the carbonyl carbon and oxygen atoms, leads to the dearomatized complex [(iPr-PNP*)Fe(CO)(EtO)(MeCH(OH)Ph)] (32).	Oxygen	158-164	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	224-227
27105496-3	2016	The impaired proliferation and increased senescence in Gadd45b null MEFs is partially reversed by culturing at physiological oxygen levels, indicating that Gadd45b deficiency leads to decreased ability to cope with oxidative stress.	Oxygen	125-131	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	55-62
22577772-3	2012	Group 1 mice were exposed to oxygen concentrations of 75 +- 2% from postnatal day (P) 7 to P12.	Oxygen	29-35	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	91-94
22349394-6	2012	Glomus cells, the site of O(2) sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H(2)S generating enzyme.	Oxygen	26-30	cystathionase (cystathionine gamma-lyase)	Mus musculus	68-93
22349394-6	2012	Glomus cells, the site of O(2) sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H(2)S generating enzyme.	Oxygen	26-30	cystathionase (cystathionine gamma-lyase)	Mus musculus	95-98
22282471-8	2012	Moreover, the Nor-1 transgenic line displayed significant improvements in glucose tolerance, oxygen consumption, and running endurance (in the absence of increased insulin sensitivity), consistent with increased oxidative capacity of skeletal muscle.	Oxygen	93-99	nuclear receptor subfamily 4, group A, member 3	Mus musculus	14-19
22318826-8	2012	CRP and arterial oxygen tension (PaO2) were significantly correlated with both serum VEGF (p=0.032 and p=0.016, respectively) and Ang-2 levels (p&lt;0.001 and p=0.041, respectively), after adjusting for other factors.	Oxygen	17-23	angiopoietin 2	Homo sapiens	130-135
22293507-9	2012	The levels of two fragments of caspase 9 in the cortex were higher in the control group compared with the hyperbaric oxygen-exposed group 1h after seizures (p&lt;0.01).	Oxygen	117-123	caspase 9	Mus musculus	31-40
27105496-3	2016	The impaired proliferation and increased senescence in Gadd45b null MEFs is partially reversed by culturing at physiological oxygen levels, indicating that Gadd45b deficiency leads to decreased ability to cope with oxidative stress.	Oxygen	125-131	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	156-163
22803330-7	2012	In the ligand-free enzyme, the distance between the oxygen atom of 3-OH group of PLP pyridine ring and oxygen atom of Thr246 hydroxyl group is not favorable for hydrogen bonding.	Oxygen	52-58	pyridoxal phosphatase	Homo sapiens	81-84
22803330-7	2012	In the ligand-free enzyme, the distance between the oxygen atom of 3-OH group of PLP pyridine ring and oxygen atom of Thr246 hydroxyl group is not favorable for hydrogen bonding.	Oxygen	103-109	pyridoxal phosphatase	Homo sapiens	81-84
22223315-5	2012	RESULTS: This study showed that TGB was degraded by oxidative pathways involving attack of oxygen at different centers but mainly at the double bond of the molecule.	Oxygen	91-97	pro-platelet basic protein	Homo sapiens	32-35
27151080-6	2016	Conversely, an increased oxygen consumption and mitochondria hyperpolarization were observed in C9ORF72 fibroblasts in association to increased ROS and ATP content.	Oxygen	25-31	C9orf72-SMCR8 complex subunit	Homo sapiens	96-103
22191377-1	2012	Oxygen responsive sensor platforms were fabricated by pin printing tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) ([Ru(dpp)(3)](2+)) doped sols onto wavelength tuned reflective Bragg gratings.	Oxygen	0-6	dentin sialophosphoprotein	Homo sapiens	124-127
22752906-8	2012	ArcA was identified as the dominant repressor, with the major repression occurring at 0-4% oxygen.	Oxygen	91-97	arginine deiminase	Escherichia coli	0-4
26667899-0	2016	60 YEARS OF POMC: From POMC and alpha-MSH to PAM, molecular oxygen, copper, and vitamin C.	Oxygen	60-66	pro-opiomelanocortin-alpha	Mus musculus	12-16
22494900-4	2012	Experiments were conducted to investigate the effects of the initial oxygen pressure and temperature on the COD (chemical oxygen demand), TOC (total organic carbon) removal and biodegradable enhancement, it was discovered that over 40% of COD and TOC removal can be easily realized in an hour of WAO oxidation at 523 K, 1.4 MPa.	Oxygen	69-75	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	108-111
22494900-4	2012	Experiments were conducted to investigate the effects of the initial oxygen pressure and temperature on the COD (chemical oxygen demand), TOC (total organic carbon) removal and biodegradable enhancement, it was discovered that over 40% of COD and TOC removal can be easily realized in an hour of WAO oxidation at 523 K, 1.4 MPa.	Oxygen	69-75	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	239-242
22494900-5	2012	The BOD(5)/COD (BOD(5), biochemical oxygen demand in 5 days) of this two pharmaceutical mixture ascended from nonexistent to maximum 0.41 depends on the optimal FPW:BPW volume ratio 4:1, to compose POM co-catalyst system.	Oxygen	36-42	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	4-14
22191377-2	2012	In an epi-luminescence configuration, these Bragg gratings (Gr) were designed to selectively reflect the O(2) responsive [Ru(dpp)(3)](2+) emission toward the detector to enhance the detected signal magnitude.	Oxygen	105-109	dentin sialophosphoprotein	Homo sapiens	125-128
22249123-4	2012	The attachment of an hydroxyl group to this position and the movement of the oxygen by one atom distal from N(9) in the purine ring compared with 2-(phosphonoethoxy)ethyl hypoxanthine (PEEHx) and 2-(phosphonoethoxy)ethyl guanine (PEEG) changes the affinity and selectivity for human HGPRT, PfHGXPRT and PvHGPRT.	Oxygen	77-83	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	283-288
26966066-0	2016	PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARgamma via PEDF-R in H9c2 cells.	Oxygen	44-50	serpin family F member 1	Rattus norvegicus	0-4
22288477-9	2012	The ability of BDNF to modify brain metabolism and the efficiency of oxygen utilization via a MEK-Bcl-2 pathway may be an important component of the neuroprotective action observed with this neurotrophin.	Oxygen	69-75	midkine	Mus musculus	94-97
22191804-2	2012	Electrons transferred from cytochrome c to CcO"s catalytic site reduce molecular oxygen and produce a water molecule.	Oxygen	81-87	LOC104968582	Bos taurus	27-39
22678294-3	2012	Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (mTOR)-dependent mechanisms.	Oxygen	4-10	eukaryotic translation initiation factor 4E	Homo sapiens	80-85
22678294-7	2012	We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.	Oxygen	77-83	eukaryotic translation initiation factor 4E	Homo sapiens	189-194
22670549-0	2012	Hyperbaric oxygen therapy reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis.	Oxygen	11-17	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	34-39
22191804-2	2012	Electrons transferred from cytochrome c to CcO"s catalytic site reduce molecular oxygen and produce a water molecule.	Oxygen	81-87	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	43-46
26966066-0	2016	PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARgamma via PEDF-R in H9c2 cells.	Oxygen	44-50	serpin family F member 1	Rattus norvegicus	9-13
26966066-0	2016	PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARgamma via PEDF-R in H9c2 cells.	Oxygen	44-50	serpin family F member 1	Rattus norvegicus	9-13
26959344-7	2016	Furthermore, MD simulations were in good agreement with the experiments, from which it is suggested that the terminal oxygen atoms of the G4 in [Li(G4)](+) solvated cation frequently repeat coordinating/uncoordinating to the Li(+), although almost all of the G4 coordinates to the Li(+) to form [Li(G4)](+) solvated cation in the neat and HFE diluted [Li(G4)][TFSA] solvate ionic liquid.	Oxygen	118-124	homeostatic iron regulator	Homo sapiens	339-342
22111949-0	2012	The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.	Oxygen	98-105	galectin 3	Homo sapiens	33-43
22400486-3	2012	In this paper, using piezoresponse force microscopy we demonstrate a switchable electromechanical response of the LAO overlayer, which we attribute to the motion of oxygen vacancies through the LAO layer thickness.	Oxygen	165-171	interleukin 4 induced 1	Homo sapiens	114-117
22400486-3	2012	In this paper, using piezoresponse force microscopy we demonstrate a switchable electromechanical response of the LAO overlayer, which we attribute to the motion of oxygen vacancies through the LAO layer thickness.	Oxygen	165-171	interleukin 4 induced 1	Homo sapiens	194-197
22485113-6	2012	The short-range ordered natural Fh (Fh(SRO)) phases were stable at 4 C in the presence of oxygen for at least 1 year and during 400 C treatment.	Oxygen	90-96	stomatin like 3	Homo sapiens	36-43
22148553-2	2012	However, two evolutionarily related single-domain sulfhydryl oxidases (Erv2p; a yeast endoplasmic reticulum resident protein and augmenter of liver regeneration, ALR, an enzyme predominantly found in the mitochondrial intermembrane) release up to ~30% of the oxygen they reduce as the superoxide ion.	Oxygen	259-265	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	71-76
26781224-2	2016	Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids.	Oxygen	323-329	CREB regulated transcription coactivator 1	Mus musculus	168-174
22729865-1	2012	Cytochrome c oxidase (COX) catalyzes the last step in respiration, transferring electrons from cytochrome c to molecular oxygen and coupling electron transfer with proton translocation from the mitochondrial matrix to the intermembrane space.	Oxygen	121-127	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
22366232-1	2012	Rainbow trout myoglobin (Mb) is characterized by an unusually low affinity for oxygen, having a P(50) of 4.92+-0.29 mm Hg at 25  C which is the highest ever reported for any vertebrate Mb at the same temperature (Helbo and Fago, (2011) Am.	Oxygen	79-85	myoglobin	Oncorhynchus mykiss	14-23
22419111-5	2012	Accordingly, Tat decreases substrate oxidation by mitochondria isolated from these tissues, with oxygen uptake being initially restored by adding cytochrome c.	Oxygen	97-103	tyrosine aminotransferase	Homo sapiens	13-16
26951478-2	2016	This study aimed to investigate the contribution of PGC-1alpha inactivation to the development of oxygen-induced retinopathy.	Oxygen	98-104	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	52-62
22238345-1	2012	Cytochrome c oxidase (COX), the last enzyme of the respiratory chain of aerobic organisms, catalyzes the reduction of molecular oxygen to water.	Oxygen	128-134	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
22207131-8	2012	The activation of mTORC1 and the acceleration of T(h)17-cell differentiation, which occurred when cells were primed under 5% O(2), were not observed in the absence of HIF-1alpha but were accelerated in the absence of von Hippel-Lindau tumor suppressor protein (vHL), a factor critical for HIF-1alpha degradation.	Oxygen	125-129	CREB regulated transcription coactivator 1	Mus musculus	18-24
22207131-8	2012	The activation of mTORC1 and the acceleration of T(h)17-cell differentiation, which occurred when cells were primed under 5% O(2), were not observed in the absence of HIF-1alpha but were accelerated in the absence of von Hippel-Lindau tumor suppressor protein (vHL), a factor critical for HIF-1alpha degradation.	Oxygen	125-129	von Hippel-Lindau tumor suppressor	Homo sapiens	261-264
22262032-3	2012	The initial step is dominated by OH addition to the C(1)-position of Nap, forming radical C(10)H(8)-1-OH (R1), followed by the O(2) additions to the C(2) position to form peroxy radical R1-2OO, or by the hydrogen abstraction by O(2) to form 1-naphthol.	Oxygen	171-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	82-104
22262032-3	2012	The initial step is dominated by OH addition to the C(1)-position of Nap, forming radical C(10)H(8)-1-OH (R1), followed by the O(2) additions to the C(2) position to form peroxy radical R1-2OO, or by the hydrogen abstraction by O(2) to form 1-naphthol.	Oxygen	171-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	106-108
22262032-3	2012	The initial step is dominated by OH addition to the C(1)-position of Nap, forming radical C(10)H(8)-1-OH (R1), followed by the O(2) additions to the C(2) position to form peroxy radical R1-2OO, or by the hydrogen abstraction by O(2) to form 1-naphthol.	Oxygen	171-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	186-188
22196347-4	2012	It was also shown that hydrating the SnO(x)/Sn nanoparticles similarly improved the PL response of the nanoparticles as the hydration produced an additional oxygen-rich oxide layer on the particle surface.	Oxygen	157-163	strawberry notch homolog 1	Homo sapiens	37-40
22178387-5	2012	We have evaluated the regulation of hypoxia-induced translation inhibition in nerve growth factor (NGF)-differentiated PC12 cells subjected to a low oxygen concentration (0.1%) at several times.	Oxygen	149-155	nerve growth factor	Rattus norvegicus	99-102
22240163-12	2012	In mouse brain ethanol increased gp91phox expression coincided with increased production of O2- and O2- - derived oxidants.	Oxygen	92-94	cytochrome b-245, beta polypeptide	Mus musculus	33-41
22240163-12	2012	In mouse brain ethanol increased gp91phox expression coincided with increased production of O2- and O2- - derived oxidants.	Oxygen	100-102	cytochrome b-245, beta polypeptide	Mus musculus	33-41
23080150-7	2012	CSE knockout mice displayed absence of hypoxia-evoked H2S generation and severely impaired sensory excitation by low O2.	Oxygen	117-119	cystathionase (cystathionine gamma-lyase)	Mus musculus	0-3
22016505-7	2012	Higher galectin-3 levels were associated with other measures of heart failure severity, including higher New York Heart Association class, lower systolic blood pressure, higher creatinine, higher amino-terminal proB-type natriuretic peptide (NTproBNP), and lower maximal oxygen consumption.	Oxygen	271-277	galectin 3	Homo sapiens	7-17
21903173-7	2012	These results together show that conserved residues in wild type (WT) Mb were fixated under a selection pressure of low P(O2).	Oxygen	122-124	myoglobin	Physeter catodon	70-72
22113277-2	2012	von Hippel-Lindau (VHL) tumor-suppressor protein binds and ubiquitylates the catalytic alpha subunit of HIF in an oxygen-dependent manner for rapid destruction via the 26S proteasome, thereby establishing VHL as a critical negative regulator of HIF.	Oxygen	114-120	von Hippel-Lindau tumor suppressor	Homo sapiens	19-22
23226270-5	2012	We found that in the hearts of db/db mice which overexpressed ACOT1, H(2)O(2) and malondialdehyde (MDA) were reduced, the activities of ATPases in mitochondria associated with mitochondrial function were promoted, the expression of uncoupling protein 3 (UCP3) contributing to oxygen wastage for noncontractile purposes was decreased, and cardiac dysfunction was attenuated, as determined by both hemodynamic and echocardiographic detections.	Oxygen	276-282	acyl-CoA thioesterase 1	Mus musculus	62-67
22701723-15	2012	CONCLUSIONS &amp; SIGNIFICANCE: Compared to 21%, resuscitation with 100% oxygen resulted in increased peroxynitrite, fragmentation of HA, inflammation, as well as TNFalpha and IL1ss expression.	Oxygen	73-79	tumor necrosis factor	Sus scrofa	163-171
22470529-7	2012	Follow-up studies in 5-30-week-old L1 heterozygous mice/islets found that HIMP1 overexpression at relatively lower levels in beta-cells has enhanced basal insulin biosynthesis, basal insulin secretion, and tolerances to low oxygen/glucose influences.	Oxygen	224-230	HIG1 domain family, member 1A	Mus musculus	74-79
22493893-1	2012	OBJECTIVE: To investigate the effects of hyperbaric oxygen (HBO) treatment on the activation of astrocytes and the expression of glia-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in the brain after traumatic brain injury (TBI).	Oxygen	52-58	glial cell derived neurotrophic factor	Rattus norvegicus	129-161
22493893-1	2012	OBJECTIVE: To investigate the effects of hyperbaric oxygen (HBO) treatment on the activation of astrocytes and the expression of glia-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in the brain after traumatic brain injury (TBI).	Oxygen	52-58	glial cell derived neurotrophic factor	Rattus norvegicus	163-167
21940948-5	2011	Second, we demonstrated that LXRalpha increased HIF-1alpha protein stability through a physical interaction between the ligand binding domain of LXRalpha and the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	162-168	nuclear receptor subfamily 1 group H member 3	Homo sapiens	29-37
21940948-5	2011	Second, we demonstrated that LXRalpha increased HIF-1alpha protein stability through a physical interaction between the ligand binding domain of LXRalpha and the oxygen-dependent degradation domain of HIF-1alpha.	Oxygen	162-168	nuclear receptor subfamily 1 group H member 3	Homo sapiens	145-153
21839860-6	2011	Absence of oxygen during protein expression increased the fraction of non-crosslinked CDO, while presence of the metal chelator EDTA had little effect.	Oxygen	11-17	cysteine dioxygenase type 1	Rattus norvegicus	86-89
21839860-8	2011	Both the enzymatic rate of cysteine oxidation and the amount of cross-linking between C93 and Y157 increased significantly upon exposure of CDO to air/oxygen and substrate cysteine in the presence of iron in a hitherto unreported two-phase process.	Oxygen	151-157	cysteine dioxygenase type 1	Rattus norvegicus	140-143
21901757-8	2011	Only in these cells, differentiation and oxygen levels clearly impacted on AC133 expression and to some extent also influenced CD133 mRNA and protein expression.	Oxygen	41-47	prominin 1	Homo sapiens	75-80
21901757-8	2011	Only in these cells, differentiation and oxygen levels clearly impacted on AC133 expression and to some extent also influenced CD133 mRNA and protein expression.	Oxygen	41-47	prominin 1	Homo sapiens	127-132
21901757-10	2011	Our results suggest that the AC133 epitope, rather than CD133 mRNA or protein, mirrors malignancy-related tumor traits such as tumor differentiation and local oxygen tension levels, and thus corroborate its role as a biologically relevant cancer marker.	Oxygen	159-165	prominin 1	Homo sapiens	29-34
21986498-10	2011	Further analyses demonstrated that oxygen consumption of Ptpmt1-depleted cells was decreased, while glycolysis was concomitantly enhanced.	Oxygen	35-41	protein tyrosine phosphatase mitochondrial 1	Homo sapiens	57-63
22008943-2	2011	The objective of the present research is to clarify the metabolic regulation mechanism on how the culture environment, such as oxygen level, affects the cell metabolism in relation to gene expressions, enzyme activities and fluxes via global regulators such as Fnr and ArcA/B systems.	Oxygen	127-133	arginine deiminase	Escherichia coli	269-273
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Oxygen	106-112	nitric oxide synthase 1, neuronal	Mus musculus	14-18
21615722-9	2011	Inhibition of nNOS with L-Arg(NO2) -L-Dbu, knockdown of nNOS and catalase, which decomposes H(2)O(2) into oxygen and water, decreased ACh-induced relaxation by half, produced a small diminution of NO production and abolished H(2)O(2) in wild-type animals, but had no effect in ApoE(-/-) mice.	Oxygen	106-112	nitric oxide synthase 1, neuronal	Mus musculus	56-60
21784784-6	2011	The GPR39-deficient animals had similar food intake but displayed almost eliminated diet-induced thermogenesis, measured by the oxygen consumption rate (Vo(2)) on change from normal to high-fat diet.	Oxygen	128-134	G protein-coupled receptor 39	Mus musculus	4-9
21887475-13	2011	Our study shows for the first time that this increase in VHL expression could be HIF-1A-dependent and serves within a negative feedback pathway during hypoxia to regulate the cell-specific oxygen threshold for HIF-1A activation.	Oxygen	189-195	von Hippel-Lindau tumor suppressor	Homo sapiens	57-60
21942444-5	2011	While the ruthenium complex attached to p-GaN under an oxygen-free atmosphere gives significantly long mean emission lifetimes for the indicator dye (ca.	Oxygen	55-61	gigaxonin	Homo sapiens	42-45
21942444-9	2011	However, for p-GaN/dye materials, the luminescence decay accelerates in the presence of O(2).	Oxygen	88-92	gigaxonin	Homo sapiens	15-18
21939459-0	2011	Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures.	Oxygen	109-115	mitogen activated protein kinase 14	Rattus norvegicus	10-13
21682571-2	2011	Trans sodium crocetinate (TSC) has been shown to increase oxygen diffusion to hypoxic tissues.	Oxygen	58-64	solute carrier family 12 member 3	Rattus norvegicus	26-29
21807611-10	2011	In conclusion, a programmed increased in cardiac gene expression of IGF-2 and IGF-2R may represent an adaptive response to reduced substrate supply (e.g. glucose and/or oxygen) in order to maintain heart growth and may be the underlying cause for increased ventricular hypertrophy and the associated susceptibility of cardiomyocytes to ischaemic damage later in life.	Oxygen	169-175	insulin-like growth factor II	Ovis aries	68-73
21807611-10	2011	In conclusion, a programmed increased in cardiac gene expression of IGF-2 and IGF-2R may represent an adaptive response to reduced substrate supply (e.g. glucose and/or oxygen) in order to maintain heart growth and may be the underlying cause for increased ventricular hypertrophy and the associated susceptibility of cardiomyocytes to ischaemic damage later in life.	Oxygen	169-175	cation-independent mannose-6-phosphate receptor	Ovis aries	78-84
21896730-0	2011	Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.	Oxygen	0-6	NADPH oxidase 4	Homo sapiens	98-113
21609753-5	2011	RESULTS: Apelin-Tg mice inhibited HFD-induced obesity without altering food intake and exhibited increased oxygen consumption and body temperature compared to non-Tg controls.	Oxygen	107-113	apelin	Mus musculus	9-15
21179001-8	2011	In contrast, AMN+LEP increased heart rate and oxygen consumption above levels in LEP or AMN-treated rats.	Oxygen	46-52	leptin	Rattus norvegicus	17-20
21718076-6	2011	The reduction potential of 17-DMAG has been determined to be -194 +- 6 mV (vs NHE) using oxygen, 1,4-naphthoquinone, and menadione as electron acceptors.	Oxygen	89-95	solute carrier family 9 member C1	Homo sapiens	78-81
21609781-8	2011	Oxygen beam irradiated cells showed phosphorylation of Chk1, Chk2 and p53.	Oxygen	0-6	checkpoint kinase 2	Homo sapiens	61-65
21609781-10	2011	The noteworthy finding of this study is the activation of the sensor proteins, ATM and ATR by oxygen irradiation and the significant activation of Chk1, Chk2 and p53 only in the oxygen beam irradiated cells.	Oxygen	178-184	checkpoint kinase 2	Homo sapiens	153-157
21069338-3	2011	SSAT1 has been reported to bind to HIF-1alpha and RACK1, resulting in oxygen-independent HIF-1 ubiquitination and degradation.	Oxygen	70-76	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	0-5
21069338-4	2011	SSAT2, a related protein, stabilizes the interaction of the VHL protein and elongin C with HIF-1 leading to oxygen-dependent HIF-1alpha ubiquitination and degradation.	Oxygen	108-114	von Hippel-Lindau tumor suppressor	Homo sapiens	60-63
21570391-4	2011	Low oxygen during FGF2-mediated expansion resulted also in a significant increase in tyrosine hydroxylase-immunoreactive (TH-ir) dopaminergic neurons as compared to high oxygen tension, but no corresponding effect was observed for dopamine release into the culture medium.	Oxygen	4-10	fibroblast growth factor 2	Rattus norvegicus	18-22
21570391-4	2011	Low oxygen during FGF2-mediated expansion resulted also in a significant increase in tyrosine hydroxylase-immunoreactive (TH-ir) dopaminergic neurons as compared to high oxygen tension, but no corresponding effect was observed for dopamine release into the culture medium.	Oxygen	170-176	fibroblast growth factor 2	Rattus norvegicus	18-22
21570391-5	2011	However, switching FGF2-expanded cultures from low to high oxygen tension during the last two days of differentiation significantly enhanced dopamine release and intracellular dopamine levels as compared to all other treatment groups.	Oxygen	59-65	fibroblast growth factor 2	Rattus norvegicus	19-23
21515660-8	2011	Overnight (24 h) exposure of ASM cells to 50% oxygen increased BDNF and TrkB expression and potentiated both SP- and BDNF-induced enhancement of [Ca(2+)](i) (P &lt; 0.05).	Oxygen	46-52	neurotrophic receptor tyrosine kinase 2	Homo sapiens	72-76
21602393-11	2011	Based on physiological, genomic, and bioinformatic results, we suggest that the sensory box protein, SO3389, is an O2/redox sensor that is involved in optimization of aerobic growth and transitions to anoxia in S. oneidensis MR-1.	Oxygen	115-117	bifunctional diguanylate cyclase/phosphodiesterase	Shewanella oneidensis MR-1	101-107
21975235-1	2011	OBJECTIVES: We sought to analyze exercise-derived mean pulmonary artery pressure (Mpap) - cardiac index (CI) - relationship to expand the concepts regarding its nature and to better identify pulmonary hemodynamic responders to acute oxygen breathing (AOB - 99.5%) in pulmonary hypertension (PH) - COPD patients.	Oxygen	233-239	phospholipid phosphatase 1	Mus musculus	82-86
21975235-11	2011	Hemodynamic benefit on the pulmonary circulation and right ventricular afterload could be expected with long-term oxygen therapy in resting &lt;30 mmHg mPAP-PH-COPD patients.	Oxygen	114-120	phospholipid phosphatase 1	Mus musculus	152-156
21446951-1	2011	The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen.	Oxygen	81-87	histocompatibility minor 13	Homo sapiens	37-40
21446951-1	2011	The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen.	Oxygen	150-156	histocompatibility minor 13	Homo sapiens	37-40
21822200-0	2011	Association between lipoprotein(a) and oxygen reactive metabolite in asymptomatic subjects.	Oxygen	39-45	lipoprotein(a)	Homo sapiens	20-34
21822200-3	2011	OBJECTIVES: The aim of the present study was to investigate the correlation between Lp(a) and oxidative status using the diacron Reactive Oxygen Metabolite (d-ROM) test as an oxidative stress-related marker in asymptomatic subjects.	Oxygen	138-144	lipoprotein(a)	Homo sapiens	84-89
21536680-11	2011	Forced overexpression of mtSSB in Saos2 cells caused an increase in mtDNA and a decrease in oxygen consumption.	Oxygen	92-98	single stranded DNA binding protein 1	Homo sapiens	25-30
21536680-12	2011	In contrast, knockdown of mtSSB in 143B cells was accompanied by a decrease in mtDNA, increase in oxygen consumption, and retardation of cell growth in vitro and in vivo.	Oxygen	98-104	single stranded DNA binding protein 1	Homo sapiens	26-31
21536681-8	2011	Consistent with these findings, hypoxia induced cPLA(2) phosphorylation and activity in VEGF-Src-PLD1-PKCgamma-dependent manner in a mouse model of oxygen-induced retinopathy.	Oxygen	148-154	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	48-54
21536681-8	2011	Consistent with these findings, hypoxia induced cPLA(2) phosphorylation and activity in VEGF-Src-PLD1-PKCgamma-dependent manner in a mouse model of oxygen-induced retinopathy.	Oxygen	148-154	phospholipase D1	Mus musculus	97-101
22442641-0	2012	beta(3)-Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs.	Oxygen	93-99	beta-3 adrenergic receptor	Ovis aries	0-20
21597910-5	2012	In multivariate analysis, the best predictors for radiographic BPD were oxygen dependency at 28 days (odds ratio (OR) 10.2 [95% confidence interval (CI) 2.49-41.4]), more than 2 days on ventilator (OR 10.4 [95% CI 1.8-61.5]) and volume expanders in the first 2 h (OR 7.36 [95% CI 1.32-41.2]).	Oxygen	72-78	olfactory receptor family 7 subfamily E member 115 pseudogene	Homo sapiens	102-122
21989481-1	2012	Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones.	Oxygen	19-25	small ubiquitin like modifier 1	Homo sapiens	73-111
22086907-2	2012	pVHL controls oxygen-responsive gene expression at the transcriptional and posttranscriptional levels.	Oxygen	14-20	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
23288995-0	2012	Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption.	Oxygen	132-138	BCL2-like 1	Mus musculus	0-6
23029459-3	2012	Cross-talk between E. coli FadR and the ArcA-ArcB oxygen-responsive two-component system was observed that resulted in diverse regulation of certain fad regulon beta-oxidation genes.	Oxygen	50-56	arginine deiminase	Escherichia coli	40-44
22768306-3	2012	Using in vivo and in vitro models, we evaluated the effect of reducing the partial pressure of oxygen (PO(2)) on NFAT5 activity.	Oxygen	95-101	nuclear factor of activated T-cells 5	Rattus norvegicus	113-118
22768306-6	2012	3) The dose-response curve demonstrated that HIF-1alpha peaked at 2.5% and NFAT5 at 1% of O(2).	Oxygen	90-94	nuclear factor of activated T cells 5	Homo sapiens	75-80
22768306-7	2012	4) At 2.5% of O(2), the time-course curve of hypoxia demonstrated earlier induction of HIF-1alpha gene expression than NFAT5.	Oxygen	14-18	nuclear factor of activated T cells 5	Homo sapiens	119-124
22679501-9	2012	Interestingly, cell surface MT1-MMP gradually disappeared when the hypoxia-treated cells were switched to normoxia, suggesting the plasticity of TICs in response to oxygen content.	Oxygen	165-171	matrix metallopeptidase 14	Homo sapiens	28-35
22973510-2	2012	Unfortunately not all patients with COPD who meet criteria for long term oxygen therapy benefit from it.	Oxygen	73-79	COPD	Homo sapiens	36-40
21963837-2	2011	In type 2 diabetes (DM2), there are defects in O(2) supply to muscle as well as a failure of erythrocytes to release ATP.	Oxygen	47-51	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	20-23
21963837-3	2011	The goal of this study was to ascertain if a phosphodiesterase 3 (PDE3) inhibitor, cilostazol, would rescue low O(2)-induced ATP release from DM2 erythrocytes and, thereby, enable these cells to dilate isolated erythrocyte-perfused skeletal muscle arterioles exposed to decreased extraluminal O(2).	Oxygen	112-116	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	142-145
21963837-6	2011	Most importantly, cilostazol restored the ability of DM2 erythrocytes to release ATP in response to low O(2).	Oxygen	104-108	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	53-56
21963837-9	2011	Thus rescue of low O(2)-induced ATP release from DM2 erythrocytes by cilostazol restored the ability of erythrocytes to participate in the regulation of perfusion distribution in skeletal muscle.	Oxygen	19-23	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	49-52
21807096-4	2011	VGLUT2 was also cleaved by calpains after oxygen/glucose deprivation (OGD), and downregulated after middle cerebral artery occlusion (MCAO) and intrahippocampal injection of kainate.	Oxygen	42-48	solute carrier family 17 member 6	Homo sapiens	0-6
21917928-4	2011	Compared with CEFs, Ski-CEFs exhibited enhanced TCA cycle activity, fatty acid catabolism through beta-oxidation, glutamate oxidation, oxygen consumption, as well as increased numbers and mass of mitochondria.	Oxygen	135-141	SKI proto-oncogene	Gallus gallus	20-23
22072684-8	2011	We also report that CX3CL1 induced a different phagocytic activity in wild type and cx3cl1-/- microglia in vitro during cotreatment with the medium conditioned by neurons damaged by oxygen-glucose deprivation.	Oxygen	182-188	chemokine (C-X3-C motif) ligand 1	Mus musculus	20-26
21832206-5	2011	Such mechanisms include decreased renal blood flow due to increased vascular tone induced by ANG II that limits oxygen delivery and increases oxidative stress, resulting in increased mitochondrial oxygen usage, increased oxygen usage for tubular electrolyte transport, and shunting of oxygen from arterial to venous blood in preglomerular vessels.	Oxygen	112-118	angiogenin	Homo sapiens	93-96
21832206-5	2011	Such mechanisms include decreased renal blood flow due to increased vascular tone induced by ANG II that limits oxygen delivery and increases oxidative stress, resulting in increased mitochondrial oxygen usage, increased oxygen usage for tubular electrolyte transport, and shunting of oxygen from arterial to venous blood in preglomerular vessels.	Oxygen	197-203	angiogenin	Homo sapiens	93-96
21832206-5	2011	Such mechanisms include decreased renal blood flow due to increased vascular tone induced by ANG II that limits oxygen delivery and increases oxidative stress, resulting in increased mitochondrial oxygen usage, increased oxygen usage for tubular electrolyte transport, and shunting of oxygen from arterial to venous blood in preglomerular vessels.	Oxygen	197-203	angiogenin	Homo sapiens	93-96
21832206-5	2011	Such mechanisms include decreased renal blood flow due to increased vascular tone induced by ANG II that limits oxygen delivery and increases oxidative stress, resulting in increased mitochondrial oxygen usage, increased oxygen usage for tubular electrolyte transport, and shunting of oxygen from arterial to venous blood in preglomerular vessels.	Oxygen	197-203	angiogenin	Homo sapiens	93-96
21999228-0	2011	RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	120-126	ras homolog family member A	Mus musculus	0-4
21969016-4	2011	METHODS AND RESULTS: In this study, we show that Wnt receptors (Frizzled4 and low-density lipoprotein receptor-related protein5 [Lrp5]) and activity are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	232-238	frizzled class receptor 4	Mus musculus	64-73
21969016-4	2011	METHODS AND RESULTS: In this study, we show that Wnt receptors (Frizzled4 and low-density lipoprotein receptor-related protein5 [Lrp5]) and activity are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	232-238	low density lipoprotein receptor-related protein 5	Mus musculus	78-127
21969016-4	2011	METHODS AND RESULTS: In this study, we show that Wnt receptors (Frizzled4 and low-density lipoprotein receptor-related protein5 [Lrp5]) and activity are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	232-238	low density lipoprotein receptor-related protein 5	Mus musculus	129-133
21895890-4	2011	The functional role of RAD-8 may be evolutionarily conserved because expression of the putative human homologue RTN4IP/NIMP in rad-8 rescued the increased sensitivity to oxygen in rad-8.	Oxygen	170-176	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	23-28
21895890-4	2011	The functional role of RAD-8 may be evolutionarily conserved because expression of the putative human homologue RTN4IP/NIMP in rad-8 rescued the increased sensitivity to oxygen in rad-8.	Oxygen	170-176	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	127-132
21895890-4	2011	The functional role of RAD-8 may be evolutionarily conserved because expression of the putative human homologue RTN4IP/NIMP in rad-8 rescued the increased sensitivity to oxygen in rad-8.	Oxygen	170-176	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	180-185
21895890-5	2011	These results suggest that RAD-8 plays an important role in oxygen metabolism in mitochondria in higher eukaryotes.	Oxygen	60-66	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	27-32
27095234-0	2016	Singlet molecular oxygen: Dusseldorf - Sao Paulo, the Brazilian connection.	Oxygen	0-24	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	39-42
26706283-2	2016	Moreover, Norrin induces vascular repair following an oxygen-induced retinopathy (OIR), the model of retinopathy of prematurity in mice.	Oxygen	54-60	Norrie disease (pseudoglioma) (human)	Mus musculus	10-16
26857347-8	2016	AT1 and Ang type 2 receptors were upregulated in the left ventricle by high O2 exposure (P5 and P10), which was prevented by Losartan treatment at P10.	Oxygen	76-78	angiotensin II receptor, type 1a	Rattus norvegicus	0-3
26887944-6	2016	In the absence of apo-acceptors, a large fraction of the oxidized holo-mNT form is converted back to reduced holo-mNT under low oxygen tension.	Oxygen	128-134	max binding protein	Mus musculus	71-74
26887944-6	2016	In the absence of apo-acceptors, a large fraction of the oxidized holo-mNT form is converted back to reduced holo-mNT under low oxygen tension.	Oxygen	128-134	max binding protein	Mus musculus	114-117
26956208-8	2016	Additionally, low oxygen tension increased proliferation and migration of lean but not obese hASCs, which correlated with an altered CD36 and CD49b immunophenotypic profile.	Oxygen	18-24	integrin subunit alpha 2	Homo sapiens	142-147
26910881-3	2016	In each case, after addition of O2 to the initial radicals, chain-terminating HO2-elimination reactions are observed to be important.	Oxygen	32-34	heme oxygenase 2	Homo sapiens	78-81
26516686-2	2016	For instance, the use of GDh NAD(+)-dependent for glucose oxidation is of great interest in biofuel cell technology because the enzyme are unaffected by the presence of molecular oxygen commonly present in electrolyte.	Oxygen	179-185	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	25-28
26929369-5	2016	Comparison between SRX and SFX structures revealed that photoreduction changes the coordination manner of the substrate and that catalytically important His255 can switch hydrogen bond partners between the backbone carbonyl oxygen of nearby Glu279 and the side-chain hydroxyl group of Thr280.	Oxygen	224-230	sulfiredoxin 1	Homo sapiens	19-22
26903622-4	2016	Overall, our results suggest that the accumulation of PSI in the mutant correlates with the redox state of the stroma rather than photodamage and that CGL71 functions under atmospheric O2 conditions to allow stable assembly of PSI.	Oxygen	185-187	uncharacterized protein	Chlamydomonas reinhardtii	151-156
21514373-3	2011	Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.	Oxygen	23-29	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	105-110
21514373-3	2011	Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.	Oxygen	23-29	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	142-147
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Oxygen	17-21	NADPH oxidase 4	Homo sapiens	6-10
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Oxygen	53-57	NADPH oxidase 4	Homo sapiens	98-102
21757736-2	2011	A controlled in vitro oxygen consumption assay was carried out to analyze the ERO1-PDI reaction.	Oxygen	22-28	prolyl 4-hydroxylase subunit beta	Homo sapiens	83-86
21562133-9	2011	Elafin blocked these MV-O2-induced changes.	Oxygen	24-26	peptidase inhibitor 3	Homo sapiens	0-6
21647537-6	2011	However, DCs differentiated under physiological oxygen level secreted higher levels of IL-12(p70) after exposure to LPS or CD40 ligand.	Oxygen	48-54	CD40 molecule	Homo sapiens	123-127
21764444-8	2011	Concentrations of MMP2 in the supernatant and expression of MT1-MMP were increased in both the 0.1% and 20% oxygen environments.	Oxygen	108-114	matrix metallopeptidase 2	Homo sapiens	18-22
21764444-8	2011	Concentrations of MMP2 in the supernatant and expression of MT1-MMP were increased in both the 0.1% and 20% oxygen environments.	Oxygen	108-114	matrix metallopeptidase 14	Homo sapiens	60-67
21764444-9	2011	The MMP2 mRNA level was increased after 1-h stimulation with 0.1% oxygen.	Oxygen	66-72	matrix metallopeptidase 2	Homo sapiens	4-8
21949641-3	2011	Here, we show that in C. elegans the Wnt ligand, LIN-44, and its Frizzled receptor, LIN-17, regulate dendrite development of the PQR oxygen sensory neuron.	Oxygen	133-139	Abnormal cell lineage protein 44	Caenorhabditis elegans	49-55
21847081-13	2011	The CD71/Ter119 assay can be used to study erythroid progenitors during their response to erythropoietic stress in vivo, for example, in anemic mice or mice housed in low oxygen conditions.	Oxygen	171-177	transferrin receptor	Mus musculus	4-8
21847081-13	2011	The CD71/Ter119 assay can be used to study erythroid progenitors during their response to erythropoietic stress in vivo, for example, in anemic mice or mice housed in low oxygen conditions.	Oxygen	171-177	lymphocyte antigen 76	Mus musculus	9-15
21193034-3	2011	Genetically manipulated mice devoid of RIP140 are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity.	Oxygen	70-76	nuclear receptor interacting protein 1	Mus musculus	39-45
21729334-7	2011	Substitution of a single oxygen atom in the terminal beta-phosphate group of a potent cofactor ADP by sulfur results in ADPbetaS, a cofactor that binds to Ire1 as well as to ADP but does not activate RNase.	Oxygen	25-31	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	155-159
21281980-6	2011	Here, using primary human peripheral blood monocytes, we show that maturation for 5 days in 0.2% oxygen results in decreased phagocytosis, and decreased CD40 and CD206 expression.	Oxygen	97-103	CD40 molecule	Homo sapiens	153-157
21281980-6	2011	Here, using primary human peripheral blood monocytes, we show that maturation for 5 days in 0.2% oxygen results in decreased phagocytosis, and decreased CD40 and CD206 expression.	Oxygen	97-103	mannose receptor C-type 1	Homo sapiens	162-167
21454942-0	2011	Obviating the requirement for oxygen in SnO2-based solid-state dye-sensitized solar cells.	Oxygen	30-36	strawberry notch homolog 1	Homo sapiens	40-43
21414312-3	2011	pSUPER-Rac1-shRNA was intravitreally injected into the mouse model of oxygen-induced retinopathy.	Oxygen	70-76	Rac family small GTPase 1	Mus musculus	7-11
21414312-10	2011	Our findings not only suggest that Rac1 may be involved in the process of RN in mouse oxygen-induced retinopathy via regulating the redox signaling, but may also provide a novel therapeutic target for hypoxia-induced retinal neovascular diseases.	Oxygen	86-92	Rac family small GTPase 1	Mus musculus	35-39
21399877-7	2011	In addition, each caspase inhibitor and siRNA differently affects ROS levels including O2 - regardless of cell growth inhibition and cell death levels.	Oxygen	87-89	caspase 8	Homo sapiens	18-25
21755484-3	2011	Correction of ctH (+)(B) from the normally low foetal oxygen saturation by reoxygenation of Hb increases ctH (+)(B), resulting in 4 different variables: ctH (+)(B,act) (=BE (B)), ctH (+)(Ecf,act) (standard BE), ctH (+)(B,ox.)	Oxygen	54-60	V-set and immunoglobulin domain containing 2	Homo sapiens	14-17
21755484-3	2011	Correction of ctH (+)(B) from the normally low foetal oxygen saturation by reoxygenation of Hb increases ctH (+)(B), resulting in 4 different variables: ctH (+)(B,act) (=BE (B)), ctH (+)(Ecf,act) (standard BE), ctH (+)(B,ox.)	Oxygen	54-60	V-set and immunoglobulin domain containing 2	Homo sapiens	105-108
21755484-3	2011	Correction of ctH (+)(B) from the normally low foetal oxygen saturation by reoxygenation of Hb increases ctH (+)(B), resulting in 4 different variables: ctH (+)(B,act) (=BE (B)), ctH (+)(Ecf,act) (standard BE), ctH (+)(B,ox.)	Oxygen	54-60	V-set and immunoglobulin domain containing 2	Homo sapiens	105-108
21755484-3	2011	Correction of ctH (+)(B) from the normally low foetal oxygen saturation by reoxygenation of Hb increases ctH (+)(B), resulting in 4 different variables: ctH (+)(B,act) (=BE (B)), ctH (+)(Ecf,act) (standard BE), ctH (+)(B,ox.)	Oxygen	54-60	V-set and immunoglobulin domain containing 2	Homo sapiens	105-108
21755484-3	2011	Correction of ctH (+)(B) from the normally low foetal oxygen saturation by reoxygenation of Hb increases ctH (+)(B), resulting in 4 different variables: ctH (+)(B,act) (=BE (B)), ctH (+)(Ecf,act) (standard BE), ctH (+)(B,ox.)	Oxygen	54-60	V-set and immunoglobulin domain containing 2	Homo sapiens	105-108
21755484-19	2011	Correction of ctH (+)(B,act) or ctH (+)(Ecf,act) to 100% oxygen saturation always leads to higher coefficients.	Oxygen	57-63	V-set and immunoglobulin domain containing 2	Homo sapiens	14-17
21755484-19	2011	Correction of ctH (+)(B,act) or ctH (+)(Ecf,act) to 100% oxygen saturation always leads to higher coefficients.	Oxygen	57-63	V-set and immunoglobulin domain containing 2	Homo sapiens	32-35
21487632-2	2011	A DFT computational investigation of the catalytic mechanism of O-GlcNAcase shows the existence of a substrate-assisted reaction pathway similar to that proposed in the literature on the basis of experimental evidence: the carbonyl oxygen of the N-acyl group bonded at C2 of the substrate pyranose ring attacks the anomeric carbon affording a bicyclic oxazoline intermediate and causing the breaking of the glycosidic bond and the expulsion of the aglycon.	Oxygen	232-238	O-GlcNAcase	Homo sapiens	64-75
21593312-6	2011	Incubation of glial-derived exosomes in the presence of high KCl concentrations or subjecting glial cell cultures to either oxygen/glucose deprivation or hydrogen peroxide resulted in release of synapsin I from exosomes.	Oxygen	124-130	synapsin I	Mus musculus	195-205
21593312-7	2011	Application of synapsin I promoted neurite outgrowth from hippocampal neurons and increased survival of cortical neurons upon hydrogen peroxide treatment or oxygen/glucose deprivation.	Oxygen	157-163	synapsin I	Mus musculus	15-25
21542902-0	2011	Tumor necrosis factor-alpha enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells.	Oxygen	48-54	nicotinamide phosphoribosyltransferase	Homo sapiens	63-71
21422382-10	2011	Leptin increased oxygen consumption in LepR(flox/flox)/POMC-Cre and wild-type mice.	Oxygen	17-23	pro-opiomelanocortin-alpha	Mus musculus	55-59
21422382-11	2011	Activation of POMC neurons is necessary for the chronic effects of leptin to raise MAP and reduce insulin and glucose levels, whereas leptin receptors in other areas of the brain other than POMC neurons appear to play a key role in mediating the chronic effects of leptin on appetite and oxygen consumption.	Oxygen	288-294	pro-opiomelanocortin-alpha	Mus musculus	14-18
21316481-8	2011	Furthermore, because the pVHL-FIH interaction depends on oxygen tension, the FIH-mediated inactivation of HIF-1alpha can be exquisitely regulated according to the severity of hypoxia.	Oxygen	57-63	von Hippel-Lindau tumor suppressor	Homo sapiens	25-29
21316481-9	2011	Based on these findings, we propose that pVHL fine-tunes the transcriptional activity of HIF-1alpha in graded oxygen tensions.	Oxygen	110-116	von Hippel-Lindau tumor suppressor	Homo sapiens	41-45
21376735-3	2011	DRS uses shallow-penetrating visible light to assess microvascular oxygen saturation (SmvO(2)) in superficial tissue.	Oxygen	67-73	sushi repeat containing protein X-linked	Homo sapiens	0-3
21376735-10	2011	The results from baseline measurements indicate a surprisingly high oxygen extraction in the measurement volume of DRS, especially in the groin skin.	Oxygen	68-74	sushi repeat containing protein X-linked	Homo sapiens	115-118
21376735-12	2011	Microvascular disturbances have been demonstrated in both local vascular diseases and systemic conditions such as shock and sepsis, an assessment of microvascular oxygen saturation using DRS may be useful in the monitoring of the microcirculation in such patients.	Oxygen	163-169	sushi repeat containing protein X-linked	Homo sapiens	187-190
21481773-1	2011	Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth.	Oxygen	182-188	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	57-98
21481773-1	2011	Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth.	Oxygen	182-188	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	100-105
21209098-1	2011	Inhibition of large conductance calcium-activated potassium (BKCa) channels mediates, in part, oxygen sensing by carotid body type I cells.	Oxygen	95-101	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	61-65
21355610-4	2011	The O2-insensitive GDH/Au NPs composite electrode was further used as an anode in a membraneless glucose/O2 biofuel cell.	Oxygen	4-6	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	19-22
21148793-5	2011	Consistent with this hypothesis, we observed that the parenchymal thickening induced by exposure to 60% O(2) was associated with decreased numbers of apoptotic cells, increased expressions of the antiapoptotic regulator Bcl-xL, and the putative antiapoptotic protein survivin, and decreased expressions of the proapoptotic cleaved caspases-3 and -7.	Oxygen	104-108	Bcl2-like 1	Rattus norvegicus	220-226
21148793-5	2011	Consistent with this hypothesis, we observed that the parenchymal thickening induced by exposure to 60% O(2) was associated with decreased numbers of apoptotic cells, increased expressions of the antiapoptotic regulator Bcl-xL, and the putative antiapoptotic protein survivin, and decreased expressions of the proapoptotic cleaved caspases-3 and -7.	Oxygen	104-108	caspase 3	Rattus norvegicus	331-348
21193583-0	2011	Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice.	Oxygen	87-93	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	0-21
21193583-14	2011	We conclude that oxygen acts primarily through the complex CYP3A13 (sensor)/ET-1 (effector) and, in an accessory way, directly onto ET-1.	Oxygen	17-23	cytochrome P450, family 3, subfamily a, polypeptide 13	Mus musculus	59-66
20851096-0	2011	Oxygen activation by P450(cin): Protein and substrate mutagenesis.	Oxygen	0-6	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	21-25
20851096-0	2011	Oxygen activation by P450(cin): Protein and substrate mutagenesis.	Oxygen	0-6	pyridoxal phosphatase	Homo sapiens	26-29
20851096-1	2011	A conserved threonine found in the majority of cytochromes P450 (P450s) has been implicated in the activation of dioxygen during the catalytic cycle.	Oxygen	113-121	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	59-63
20851096-4	2011	To explore further how P450(cin) controls the activation of the dioxygen in the absence of the conserved threonine, two concurrent lines of investigation were followed.	Oxygen	64-72	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	23-27
20851096-4	2011	To explore further how P450(cin) controls the activation of the dioxygen in the absence of the conserved threonine, two concurrent lines of investigation were followed.	Oxygen	64-72	pyridoxal phosphatase	Homo sapiens	28-31
21222437-2	2011	Phototropin is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) that absorb blue light and a serine/theroine kinase domain responsible for light-dependent autophosphorylation leading to cellular signaling cascades.	Oxygen	37-43	phototropin 1	Arabidopsis thaliana	0-11
21192081-3	2011	OIR was induced by exposure of mice to 75% oxygen from postnatal day 7 (P7) to P11 and then room air until P18.	Oxygen	43-49	S100 calcium binding protein A10 (calpactin)	Mus musculus	79-82
21304818-1	2011	Neuroglobin (Ngb) is a recently discovered vertebrate globin that is expressed in the brain and can reversibly bind oxygen.	Oxygen	116-122	neuroglobin	Danio rerio	0-11
21304818-1	2011	Neuroglobin (Ngb) is a recently discovered vertebrate globin that is expressed in the brain and can reversibly bind oxygen.	Oxygen	116-122	neuroglobin	Danio rerio	13-16
21304820-11	2011	Finally, the capacity for an animal to survive long bouts of severe oxygen deprivation is likely dependent on specific subunits of the heterotrimeric protein AMPK and energy stores such as carbohydrates.	Oxygen	68-74	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	158-162
21048020-11	2011	In a human proximal tubular cell culture, we show that PEDF downregulates HIF1alpha protein and gene expression in cells exposed to 1% oxygen.	Oxygen	135-141	serpin family F member 1	Homo sapiens	55-59
21155973-2	2011	The VHL locus encodes pVHL, whose best studied function is to bind to and down-regulate the hypoxia-inducible factor (HIF) family of oxygen-dependent transcription factors.	Oxygen	133-139	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
21155973-2	2011	The VHL locus encodes pVHL, whose best studied function is to bind to and down-regulate the hypoxia-inducible factor (HIF) family of oxygen-dependent transcription factors.	Oxygen	133-139	von Hippel-Lindau tumor suppressor	Homo sapiens	22-26
21190891-2	2011	Potential of hydrogen bond is the function which relates its energy to geometrical parameters of hydrogen bridge: its length R(O...O) and angles between direction O...O and OH group [phi (H-O...O)] and/or lone pair of proton accepting oxygen atom [chi(-O...O)].	Oxygen	235-241	glucose-6-phosphate isomerase	Homo sapiens	183-186
20950274-5	2011	However, mesohaem-nNOS had a decreased rate of Fe(III) haem reduction and had increased rates for haem-dioxy transformation, Fe(III) haem-NO dissociation and Fe(II) haem-NO reaction with O2.	Oxygen	187-189	nitric oxide synthase 1	Homo sapiens	18-22
20849524-3	2011	DESIGN AND METHODS: In 529 patients with suspected or confirmed peripheral vascular disease not receiving beta-blockers (61 4 +- 11 3 years old), we retrospectively studied the relationship of HRR1 to exercise-induced changes in transcutaneous oxygen DROP index (limb changes minus chest changes from rest).	Oxygen	244-250	nuclear receptor subfamily 1 group H member 4	Homo sapiens	193-197
21484034-7	2011	RESULTS: After excluding the first minute of CPX (rest-exercise transition), the relative O2 pulse curve exhibited a linear increase, as demonstrated by high coefficients of determination (R2 from 0.75 to 0.90; p &lt; 0.05 for all quintiles).	Oxygen	90-92	T-box transcription factor 22	Homo sapiens	45-48
21736542-0	2011	Jun dimerization protein 2 in oxygen restriction; control of senescence.	Oxygen	30-36	Jun dimerization protein 2	Mus musculus	0-26
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Oxygen	0-6	Jun dimerization protein 2	Mus musculus	37-41
26982166-3	2016	We found that elevations of whole lung HMGB1 level were associated with impaired alveolar development and aberrant elastin production in 85% O2-exposed lungs.	Oxygen	141-143	high mobility group box 1	Mus musculus	39-44
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Oxygen	0-6	Jun dimerization protein 2	Mus musculus	51-55
21736542-7	2011	The newly defined mechanisms that underlie the action of oxygen in the induction of JDP2 and cellular senescence are reviewed.	Oxygen	57-63	Jun dimerization protein 2	Mus musculus	84-88
27063159-7	2016	Linear correlation analysis revealed that serum cystatin C was positively correlated with gender, BMI, neck circumference, abdominal circumference, SBP, AHI, and WBC (P&lt;0.01) and inversely correlated with the average pulse oxygen saturation (ASpO2), minimum pulse oxygen saturation (MSpO(2)), and SOD (P&lt;0.01).	Oxygen	226-232	cystatin C	Homo sapiens	48-58
20658530-2	2011	Developmental and pathological studies suggested an apparent correlation between oxygen deprivation and tuftelin expression.	Oxygen	81-87	tuftelin 1	Rattus norvegicus	104-112
20658530-5	2011	Furthermore, we demonstrated the induction of tuftelin during hypoxia by oxygen deprivation and during chemical hypoxia by cobalt chloride.	Oxygen	73-79	tuftelin 1	Rattus norvegicus	46-54
20952484-2	2011	Steady-state kinetics study showed that it initially behaved as a competitive-type inhibitor with a K(i) value of 5.7 x 10(-9) M, then after a few minutes it formed a tight complex with XOR via a Mo-oxygen-carbon atom covalent linkage, as reported previously (Proc Natl Acad Sci USA 101:7931-7936, 2004).	Oxygen	199-205	xanthine dehydrogenase	Rattus norvegicus	186-189
27063159-7	2016	Linear correlation analysis revealed that serum cystatin C was positively correlated with gender, BMI, neck circumference, abdominal circumference, SBP, AHI, and WBC (P&lt;0.01) and inversely correlated with the average pulse oxygen saturation (ASpO2), minimum pulse oxygen saturation (MSpO(2)), and SOD (P&lt;0.01).	Oxygen	267-273	cystatin C	Homo sapiens	48-58
26678362-2	2016	Hb Kirksey, a rare Hb variant involving mutation at codon 94 of alpha2-globin, is associated with low oxygen affinity.	Oxygen	102-108	hemoglobin subunit alpha 2	Homo sapiens	64-77
20978083-2	2011	The u-ATP9 transgene driven by A9 and APETALA3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and adenine nucleotides (ATP, ADP) levels without changes in the ATP/ADP ratio.	Oxygen	121-127	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	38-46
27110486-7	2016	Without affecting thermogenic gene transcription, Them1 reduced O2 consumption rates in both isolated BAT and primary brown adipocytes.	Oxygen	64-66	acyl-CoA thioesterase 11	Mus musculus	50-55
20930543-4	2010	Chronic culturing of BT474 cells in 1% O2 up to 142 days consistently demonstrated a high level of SLC19A3 expression with a mean of approximately 40 fold with no change in SLC19A2.	Oxygen	39-41	solute carrier family 19 member 3	Homo sapiens	99-106
20930543-6	2010	Acute 1% O2 exposure of BT474 cells up to 72 h demonstrated a 7.5 fold increase in SLC19A3 expression.	Oxygen	9-11	solute carrier family 19 member 3	Homo sapiens	83-90
26829707-4	2016	At 900  C, the oxygen permeation flux of the bare membrane was 1.6 (STP) ml cm(-2) min(-1) for the air/He-case and 10.10 (STP) ml cm(-2) min(-1) for the air/CO-case.	Oxygen	15-21	sulfotransferase family 1A member 1	Homo sapiens	68-71
20798245-2	2010	We showed that activation of PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasing PDK2 activity and increasing PDH activity, accelerating oxygen consumption, and augmenting ATP synthesis.	Oxygen	187-193	protein kinase C delta	Homo sapiens	29-37
20798245-2	2010	We showed that activation of PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasing PDK2 activity and increasing PDH activity, accelerating oxygen consumption, and augmenting ATP synthesis.	Oxygen	187-193	pyruvate dehydrogenase kinase 2	Homo sapiens	72-103
20920510-2	2010	Here, we tested the hypothesis that alpha-KA concentrations are regulated by complex II (succinate dehydrogenase=SDH), which represents an intersection between the mitochondrial respiratory chain for which an important function in cardiopulmonary oxygen sensing has been demonstrated, and the Krebs cycle, a central element of alpha-KA metabolism.	Oxygen	247-253	serine dehydratase	Mus musculus	113-116
26829707-4	2016	At 900  C, the oxygen permeation flux of the bare membrane was 1.6 (STP) ml cm(-2) min(-1) for the air/He-case and 10.10 (STP) ml cm(-2) min(-1) for the air/CO-case.	Oxygen	15-21	sulfotransferase family 1A member 1	Homo sapiens	122-125
26829707-7	2016	An increase of the oxygen flux of ~1.49 (STP) mL cm(-2) min(-1) at 900  C was observed when catalyst is added for the air/He-case.	Oxygen	19-25	sulfotransferase family 1A member 1	Homo sapiens	41-44
26935614-10	2016	CONCLUSION: Hyperbaric oxygen preconditioning protected the integrity of BBB in an in vitro model through modulation of occludin and ZO-1 expression under hypoxic conditions.	Oxygen	23-29	occludin	Homo sapiens	120-128
20886873-1	2010	Computational studies have suggested that eta(3)-lithium enolates in which the cation is partially bound to both carbon and oxygen may be important reactive intermediates.	Oxygen	124-130	endothelin receptor type A	Homo sapiens	42-45
26721594-5	2016	Reduction of ClpP levels by ~70% in C2C12 muscle cells resulted in a number of mitochondrial alterations including reduced mitochondrial respiration and reduced oxygen consumption rate in response to electron transport chain (ETC) complex I and II substrates.	Oxygen	161-167	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Mus musculus	13-17
20732396-6	2010	SFN was also able to prevent the CIS-induced mitochondrial alterations both in LLC-PK1 cells (loss of membrane potential) and in isolated mitochondria (inhibition of mitochondrial calcium uptake, release of cytochrome c, and decrease in GSH content, aconitase activity, adenosine triphosphate (ATP) content and oxygen consumption).	Oxygen	311-317	14-3-3 protein sigma	Sus scrofa	0-3
21175614-8	2011	The post-error contrast revealed a relative increase in blood-oxygen-level dependent (BOLD) signal in the middle/inferior temporal cortex (TempC), the ACC/supplementary motor area (SMA) and the somatosensory/auditory cortex (AudC) in children with ADHD compared to controls.	Oxygen	62-68	survival of motor neuron 1, telomeric	Homo sapiens	151-185
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	carbonic anhydrase 9	Homo sapiens	49-53
20734249-7	2011	By comparing three toxins, cobalt represented the most potent inducer of overall cell death and resembled most closely the previously observed effects of oxygen deprivation on decreasing the cox4i1/cox4i2 ratio.	Oxygen	154-160	cytochrome c oxidase subunit 4I1	Homo sapiens	191-197
20734249-7	2011	By comparing three toxins, cobalt represented the most potent inducer of overall cell death and resembled most closely the previously observed effects of oxygen deprivation on decreasing the cox4i1/cox4i2 ratio.	Oxygen	154-160	cytochrome c oxidase subunit 4I2	Homo sapiens	198-204
21548565-9	2011	Small changes in the enhancement of the CCNH(2), COO(-), and -CONH- group modes upon adsorption, which were consistent with the adsorption of these peptides, also occurred (with slightly different strengths) through the nitrogen and oxygen lone pair of electrons in these groups.	Oxygen	233-239	cyclin H	Homo sapiens	40-44
20833648-5	2010	Sca-1(+) cells with mito-Cx-43 reduced cytosolic accumulation of cytochrome c, lowered caspase-3 activity, and improved survival during index oxygen-glucose deprivation as determined by terminal deoxynucleotidyl transferase dUTP nick-end labelling and lactate dehydrogenase assays.	Oxygen	142-148	gap junction protein, alpha 3	Mus musculus	25-30
20847132-8	2010	At 2% O(2), LH2 and LOX gene expression levels were higher than control cultures (340 +- 53 and 136 +- 29%, respectively), and these levels increased even further with decreasing oxygen concentrations (611 +- 176 and 228 +- 45%, respectively, at 0.5% O(2)).	Oxygen	6-10	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	12-15
20847132-10	2010	Collagen synthesis and LH2 protein levels increased at oxygen concentrations of 2% and lower.	Oxygen	55-61	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	23-26
21265092-5	2010	RESULTS: (1) ACE2 protein expression decreased after hypoxia treatment for 3 h, 6 h, 12 h, and 24 hour compared with regular oxygen condition (chi2 = 825.078, 768.141, 623.931, 350.260, P &lt; 0.00625), the maximum reduction came at 3 h after hypoxia exposure, then raised gradually after 6 h, 12 h, and 24 h exposure; (2) ACE2 mRNA expression show a similar tendency to ACE2 protein.	Oxygen	125-131	angiotensin converting enzyme 2	Homo sapiens	13-17
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	carbonic anhydrase 9	Homo sapiens	55-76
20869947-6	2010	We have found that RNA interference-mediated knockdown of FASTKD3 severely blunts basal and stress-induced mitochondrial oxygen consumption without disrupting the assembly of respiratory chain complexes.	Oxygen	121-127	FAST kinase domains 3	Homo sapiens	58-65
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	C-X-C motif chemokine ligand 12	Homo sapiens	141-145
26788728-2	2016	Elevated levels of myoglobin within the muscles are a consistent hallmark of this trait, allowing oxygen collected at the surface to be stored in the muscles and subsequently used to support extended dives.	Oxygen	98-104	myoglobin	Bos taurus	19-28
20967197-4	2010	Consistent with predictions of the PD model, we show adaptation (i.e., a lower level) of the blood oxygen level dependent (BOLD) time-course signal in M1, PMC, SMA, and cerebellum when consecutive wrist movements were made in the same direction (0  offset) relative to movements offset by 90  or 180 .	Oxygen	99-105	survival of motor neuron 1, telomeric	Homo sapiens	160-163
20973793-3	2010	In the presence of oxygen, HIF1alpha is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1alpha for proteasomal degradation.	Oxygen	19-25	von Hippel-Lindau tumor suppressor	Homo sapiens	116-120
26753564-9	2016	Interestingly, hypoxic exposure markedly activated the PERK pathway in HCC cells in vitro, suggesting that PlGF inhibition may diminish PERK activation by improving oxygen delivery.	Oxygen	165-171	placental growth factor	Mus musculus	107-111
20713914-3	2010	This defect in cAMP signaling was also evident in endothelium-denuded aortic rings, consistent with the enhancement of mitochondrial O2 - production only in IEX-1-deficient vascular smooth muscle cells, not in endothelial cells.	Oxygen	133-135	immediate early response 3	Mus musculus	157-162
27165902-1	2016	This study investigates 55 intracranial pressure (ICP) plateau waves recorded in 20 patients after severe traumatic brain injury (TBI) with a focus on a moving correlation coefficient between mean arterial pressure (ABP) and ICP, called PRx, which serves as a marker of cerebrovascular reactivity, and a moving correlation coefficient between ABP and cerebral partial pressure of oxygen (pbtO2), called ORx, which serves as a marker for cerebral oxygen reactivity.	Oxygen	380-386	amine oxidase copper containing 1	Homo sapiens	216-219
19961314-4	2010	Trans-sodium crocetinate (TSC) is a carotenoid compound that has been shown to increase tissue oxygenation by facilitating the diffusivity of small molecules, such as oxygen and glucose.	Oxygen	95-101	solute carrier family 12 member 3	Rattus norvegicus	26-29
19961314-14	2010	Recordings of oxygen levels in the ischemic penumbra of the temporary ischemia model showed that TSC increased tissue oxygenation during vascular occlusion, but reduced the oxygen overshoot (hyperoxygenation) that occurs upon reperfusion.	Oxygen	14-20	solute carrier family 12 member 3	Rattus norvegicus	97-100
19961314-14	2010	Recordings of oxygen levels in the ischemic penumbra of the temporary ischemia model showed that TSC increased tissue oxygenation during vascular occlusion, but reduced the oxygen overshoot (hyperoxygenation) that occurs upon reperfusion.	Oxygen	118-124	solute carrier family 12 member 3	Rattus norvegicus	97-100
27165902-1	2016	This study investigates 55 intracranial pressure (ICP) plateau waves recorded in 20 patients after severe traumatic brain injury (TBI) with a focus on a moving correlation coefficient between mean arterial pressure (ABP) and ICP, called PRx, which serves as a marker of cerebrovascular reactivity, and a moving correlation coefficient between ABP and cerebral partial pressure of oxygen (pbtO2), called ORx, which serves as a marker for cerebral oxygen reactivity.	Oxygen	446-452	amine oxidase copper containing 1	Homo sapiens	216-219
27343110-7	2016	The factors that reduce the slope of the oxygen dissociation curve of the Hb (ODC) (i.e., lactic acidosis and hyperthermia) increase 1/thetaVc contributing to limit DLO2.	Oxygen	41-47	ornithine decarboxylase 1	Homo sapiens	78-81
20709391-9	2010	Culture of JAr trophoblast cells and human first trimester placental explants under low oxygen lead to increased expression of LXRA and ABCA1 which was further enhanced by the LXR agonist T0901317.	Oxygen	88-94	nuclear receptor subfamily 1 group H member 3	Homo sapiens	127-131
27526168-4	2016	Combined with oxygen probes, such as PtP-C343, we can monitor oxygen dynamics at the submicron level by this real-time microscopy.	Oxygen	14-20	protein tyrosine phosphatase receptor type U	Homo sapiens	37-40
26523859-2	2016	However, oxygen tension influences MMP/TIMP balances, potentially leading to pathology.	Oxygen	9-15	matrix metallopeptidase 2	Homo sapiens	35-38
20936147-0	2010	Mus308 processes oxygen and nitrogen ethylation DNA damage in germ cells of Drosophila.	Oxygen	17-23	DNA polymerase theta	Drosophila melanogaster	0-6
20936147-5	2010	Our results indicate that Mus308 is necessary for the processing of oxygen and N-ethylation damage, for the survival of fertilized eggs depending on the level of induced DNA damage, and for an influence of the DNA damage neighbouring sequence.	Oxygen	68-74	DNA polymerase theta	Drosophila melanogaster	26-32
20557888-6	2010	In MSC-seeded constructs supplemented with TGF-beta3, GAG and collagen accumulation was higher in low oxygen conditions compared to normoxia.	Oxygen	102-108	transforming growth factor beta 3	Homo sapiens	43-52
20560891-1	2010	PURPOSE: The aim of the current study was to investigate the effects of triamcinolone acetonide (TA) upon the expression and phosphorylation of growth-associated protein 43 (GAP 43) in the retinas of oxygen-induced retinopathy (OIR) rats.	Oxygen	200-206	growth associated protein 43	Rattus norvegicus	144-172
20560891-1	2010	PURPOSE: The aim of the current study was to investigate the effects of triamcinolone acetonide (TA) upon the expression and phosphorylation of growth-associated protein 43 (GAP 43) in the retinas of oxygen-induced retinopathy (OIR) rats.	Oxygen	200-206	growth associated protein 43	Rattus norvegicus	174-180
20560891-9	2010	CONCLUSION: Our results indicate that GAP 43 and phospho-GAP 43 participate in retinal (potentially pathologic) changes following oxygen-induced damage.	Oxygen	130-136	growth associated protein 43	Rattus norvegicus	38-44
26523859-3	2016	Intriguingly, new 2H,3H-decafluoropentane-based oxygen-loaded nanodroplets (OLNDs) have proven effective in abrogating hypoxia-dependent dysregulation of MMP and TIMP secretion by single cell populations.	Oxygen	48-54	matrix metallopeptidase 2	Homo sapiens	154-157
20560891-9	2010	CONCLUSION: Our results indicate that GAP 43 and phospho-GAP 43 participate in retinal (potentially pathologic) changes following oxygen-induced damage.	Oxygen	130-136	growth associated protein 43	Rattus norvegicus	57-63
27997891-5	2016	RESULTS: After hypoxic treatment, endothelial-1 (ET-1) and ETaR expression levels gradually increased as oxygen deprivation extended.	Oxygen	105-111	endothelin receptor type A	Rattus norvegicus	59-63
19880821-0	2010	Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.	Oxygen	55-61	BCL2-like 1	Mus musculus	23-29
19880821-10	2010	These findings reveal that the epithelial-specific expression of Bcl-X(L) is not required for proper lung development, but functions to protect respiratory epithelial cells against oxygen-induced toxicity, such as during hyperoxia and the lung"s first exposure to ambient air.	Oxygen	181-187	BCL2-like 1	Mus musculus	65-73
27997891-11	2016	PI3K and p-AKT expression levels were mildly elevated after mild oxygen deprivation, and ETaR siRNA was able to enhance such elevation induced by hypoxia.	Oxygen	65-71	endothelin receptor type A	Rattus norvegicus	89-93
20671264-7	2010	We believe HIF1alpha plays a causal role in these changes, as when oxygen-stable HIF1alpha is expressed in normoxic glioma cells CD133 is induced.	Oxygen	67-73	prominin 1	Homo sapiens	129-134
27997891-13	2016	PKG and sGC expression levels significantly descended after mild oxygen deprivation.	Oxygen	65-71	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	8-11
26065854-5	2016	Moreover, in a mouse model of oxygen-induced retinopathy, intraperitoneally injected AMSCs migrated into the retina and suppressed excessive neovascularization of the vasculature via expression of TGF-beta1, and the antineovascular effect of AMSCs was blocked by treatment with TGF-beta1 siRNA.	Oxygen	30-36	transforming growth factor, beta 1	Mus musculus	197-206
21395145-11	2010	A study of the effect of LPS-A on the immune system showed a significant reduction (36.6%) in neutrophil oxygen-dependent metabolism according to the data of the spontaneous HCT test, a 2.4-fold decrease in large circulating immune complexes, and a rise in the count of mononuclear cells that died both by necrosis and apoptosis, the count of the cells significantly increased by 5.3 times in late apoptosis.	Oxygen	105-111	Oncogene liposarcoma (DNA segment, single copy, expressed, probes MC15, MC6)	Homo sapiens	25-30
26065854-5	2016	Moreover, in a mouse model of oxygen-induced retinopathy, intraperitoneally injected AMSCs migrated into the retina and suppressed excessive neovascularization of the vasculature via expression of TGF-beta1, and the antineovascular effect of AMSCs was blocked by treatment with TGF-beta1 siRNA.	Oxygen	30-36	transforming growth factor, beta 1	Mus musculus	278-287
20645041-9	2010	Bupivacaine induced a significant decrease in the citrate synthase activity in psoas (r(2) = 0.74; P &lt; 0.001) and gracilis muscle (r(2) = 0.52; P &lt; 0.001), and there was a significant decrease in the adenosine diphosphate-stimulated oxygen consumption using glutamate or succinate as substrates in both muscles (P &lt; 0.001).	Oxygen	239-245	citrate synthase	Rattus norvegicus	50-66
26963898-7	2016	Moreover, downregulation of RyR2 increased oxygen consumption rate and decreased the expression of glucose-regulated protein 78 (GRP78), activating transcription factor 3 (ATF3) and ATF6, indicating the improvement of mitochondrial dysfunction and endoplasmic reticulum stress after SCI.	Oxygen	43-49	ryanodine receptor 2	Rattus norvegicus	28-32
27936961-10	2016	Maximum oxygen intake (beta = -0.193, P = 0.003) and resting SBP correlated with SBP after 10 years.	Oxygen	8-14	selenium binding protein 1	Homo sapiens	81-84
20510354-1	2010	Singlet oxygen is produced by the absorption of red light by the phthalocyanine dye Pc 4, followed by energy transfer to dissolved triplet oxygen.	Oxygen	8-14	keratin 6B	Homo sapiens	84-88
20616367-8	2010	RESULTS: Both Ucn2 and Ucn3 mRNA expression was significantly higher at 6 to 9 weeks of gestation than 10 to 12 wks and in primary trophoblast cell cultures and explants exposed to low O(2) tension (3%) compared to 20% O(2).	Oxygen	185-189	urocortin 2	Homo sapiens	14-18
20616367-8	2010	RESULTS: Both Ucn2 and Ucn3 mRNA expression was significantly higher at 6 to 9 weeks of gestation than 10 to 12 wks and in primary trophoblast cell cultures and explants exposed to low O(2) tension (3%) compared to 20% O(2).	Oxygen	185-189	urocortin 3	Homo sapiens	23-27
27932568-2	2016	pVHL is part of a ubiquitin ligase the targets the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for destruction when oxygen is available.	Oxygen	145-151	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
20616367-8	2010	RESULTS: Both Ucn2 and Ucn3 mRNA expression was significantly higher at 6 to 9 weeks of gestation than 10 to 12 wks and in primary trophoblast cell cultures and explants exposed to low O(2) tension (3%) compared to 20% O(2).	Oxygen	219-223	urocortin 2	Homo sapiens	14-18
20616367-8	2010	RESULTS: Both Ucn2 and Ucn3 mRNA expression was significantly higher at 6 to 9 weeks of gestation than 10 to 12 wks and in primary trophoblast cell cultures and explants exposed to low O(2) tension (3%) compared to 20% O(2).	Oxygen	219-223	urocortin 3	Homo sapiens	23-27
26672459-3	2016	In these biosensors, diamine oxidase from pea seedlings (PSAO), catalyzing the oxidation of various biogenic amines by dissolved oxygen is commonly used for the bio-recognition of amines.	Oxygen	129-135	amine oxidase copper containing 1	Homo sapiens	21-36
20096383-0	2010	Leptin integrates vertebrate evolution: from oxygen to the blood-gas barrier.	Oxygen	45-51	leptin	Mandrillus leucophaeus	0-6
27776780-1	2016	Mitochondria possess oxygen-consuming respiratory electron transfer chains (RETCs), and the oxygen-evolving photosynthetic electron transfer chain (PETC) resides in chloroplasts.	Oxygen	92-98	photosynthetic electron transfer C	Arabidopsis thaliana	148-152
20865124-4	2010	First, EGL-9 is the enzyme that targets HIF-1 for oxygen-dependent degradation via the VHL-1 E3 ligase.	Oxygen	50-56	von Hippel-Lindau tumor suppressor homolog	Caenorhabditis elegans	87-92
20727156-6	2010	RESULTS: Expression of MIF mRNA and protein was up-regulated as early as 2 hours in cultured human VSMCs after exposed to moderate hypoxia condition (3% O2).	Oxygen	153-155	macrophage migration inhibitory factor	Homo sapiens	23-26
27012070-3	2016	Mutations causing decreased affinity of hemoglobin to oxygen may change alpha1 to beta2 binding.	Oxygen	54-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-87
20408959-8	2010	Compared with room air, 100% oxygen enhanced mRNA expression of both vascular endothelial growth factor and angiopoietin-2 as well as reactive oxygen species levels in the germinal matrix.	Oxygen	29-35	angiopoietin-2	Oryctolagus cuniculus	108-122
20408818-5	2010	Both selenite and GS-Se-SG were reduced by Grx1 and Grx2 in a non-stoichiometric manner due to redox cycling with oxygen, which in turn generated ROS.	Oxygen	114-120	glutaredoxin	Homo sapiens	43-47
20415663-3	2010	Knockdown of PDH kinase 1 with siRNA (small interfering RNA) reduced its mRNA (&gt;80%) and protein level (&gt;40%) after 72 h. PDH activity, glucose-stimulated cellular oxygen consumption and pyruvate-stimulated mitochondrial oxygen consumption increased 1.7- (P&lt;0.05), 1.6- (P&lt;0.05) and 1.6-fold (P&lt;0.05) respectively.	Oxygen	170-176	pyruvate dehydrogenase kinase 1	Rattus norvegicus	13-25
25901009-7	2016	Moreover, the activity of DAO correlated negatively with the Pao 2/fraction of inspired oxygen (Fio 2) ratio (r = -.39, P = .007).	Oxygen	88-94	amine oxidase copper containing 1	Homo sapiens	26-29
20415663-3	2010	Knockdown of PDH kinase 1 with siRNA (small interfering RNA) reduced its mRNA (&gt;80%) and protein level (&gt;40%) after 72 h. PDH activity, glucose-stimulated cellular oxygen consumption and pyruvate-stimulated mitochondrial oxygen consumption increased 1.7- (P&lt;0.05), 1.6- (P&lt;0.05) and 1.6-fold (P&lt;0.05) respectively.	Oxygen	227-233	pyruvate dehydrogenase kinase 1	Rattus norvegicus	13-25
20415663-7	2010	The oxygen consumption and metabolic data strongly suggest that knockdown of PDH kinase 1 in beta-cells permits increased metabolic flux of glucose-derived carbons into the tricarboxylic acid cycle via PDH.	Oxygen	4-10	pyruvate dehydrogenase kinase 1	Rattus norvegicus	77-89
26501487-6	2016	Oxygen tension within the pregnant uterus, which contributes to the vascular development, also affects EFNB2 and EPHB4 expression.	Oxygen	0-6	Eph receptor B4	Mus musculus	113-118
20514411-5	2010	We observed that CuZnSOD and MnSOD overexpression prevents metabolic stress-induced necrosis and HMGB1 release by inhibiting mitochondrial ROS and intracellular O2- production in response to glucose depletion in two dimensional cell culture.	Oxygen	161-163	superoxide dismutase 2	Homo sapiens	29-34
20556885-3	2010	Glomus cells, the site of O2 sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H2S-generating enzyme, with hypoxia increasing H2S generation in a stimulus-dependent manner.	Oxygen	26-28	cystathionase (cystathionine gamma-lyase)	Mus musculus	66-91
20556885-3	2010	Glomus cells, the site of O2 sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H2S-generating enzyme, with hypoxia increasing H2S generation in a stimulus-dependent manner.	Oxygen	26-28	cystathionase (cystathionine gamma-lyase)	Mus musculus	93-96
26748156-8	2016	Low oxygen significantly increased the expression of both angiotensin II type 1 receptor (AGTR1) and VEGF (both P &lt; 0.05).	Oxygen	4-10	angiotensin II receptor type 1	Homo sapiens	58-88
20231286-6	2010	Recently, an atypical sGC from Drosophila, Gyc-88E, was shown to form a stable complex with oxygen.	Oxygen	92-98	Guanylyl cyclase at 88E	Drosophila melanogaster	43-50
26748156-8	2016	Low oxygen significantly increased the expression of both angiotensin II type 1 receptor (AGTR1) and VEGF (both P &lt; 0.05).	Oxygen	4-10	angiotensin II receptor type 1	Homo sapiens	90-95
26748156-9	2016	There was a positive correlation between AGTR1 and VEGF expression at low oxygen (r = 0.64, P &lt; 0.005).	Oxygen	74-80	angiotensin II receptor type 1	Homo sapiens	41-46
26748156-13	2016	Low oxygen increased AGTR1 and VEGF expression, as well as ACE and VEGF protein levels, suggesting that the proangiogenic RAS pathway is activated.	Oxygen	4-10	angiotensin II receptor type 1	Homo sapiens	21-26
20502804-0	2010	Nanostructured Pt-alloy electrocatalysts for PEM fuel cell oxygen reduction reaction.	Oxygen	59-65	mucin 1, cell surface associated	Homo sapiens	45-48
25892686-3	2015	A screen-printed electrode (SPE) was used for the immobilization of the enzymes glucose dehydrogenase (GDH) and bilirubin oxidase (BOD) for the biocatalytic oxidation of glucose and reduction of molecular oxygen, respectively.	Oxygen	205-211	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	80-101
20503366-0	2010	Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy.	Oxygen	64-70	EPH receptor B4	Homo sapiens	44-49
25892686-3	2015	A screen-printed electrode (SPE) was used for the immobilization of the enzymes glucose dehydrogenase (GDH) and bilirubin oxidase (BOD) for the biocatalytic oxidation of glucose and reduction of molecular oxygen, respectively.	Oxygen	205-211	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	103-106
26010290-0	2015	Dual Effect of Adenosine A1 Receptor Activation on Renal O2 Consumption.	Oxygen	57-59	adenosine A1 receptor	Homo sapiens	15-36
20171268-4	2010	Twenty-four hours of hypoxia (14% oxygen) commencing at E10 resulted in an increase in the density of GFAP-positive astrocytes in the medial striatum (MSt) (P&lt;0.05) and a significant reduction in the number of NeuN-positive neuronal nuclei in the intermediate medial mesopallium (IMM) (P&lt;0.02).	Oxygen	34-40	glial fibrillary acidic protein	Gallus gallus	102-106
20345897-0	2010	Ixr1p regulates oxygen-dependent HEM13 transcription.	Oxygen	16-22	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	0-5
21406611-8	2011	Expression of NIS and hCG mRNA and protein was low at 1% oxygen but rose significantly at 8 and at 21%.	Oxygen	57-63	hypertrichosis 2 (generalised, congenital)	Homo sapiens	22-25
26018820-10	2015	The up-regulation of connexin43 in combination with the down-regulation of connexin46 was confirmed in placental explants cultivated under low oxygen and in placentas with early-onset PE.	Oxygen	143-149	gap junction protein alpha 1	Homo sapiens	21-31
21377526-6	2011	Clorgyline, an inhibitor of MAO-A, markedly decreases the formation of reactive oxygen species in PC12 cells upon dopamine exposure but has only mild protective actions against quinoprotein adduct formation, mitochondrial dysfunctions, cell death and caspase activation induced by dopamine.	Oxygen	80-86	monoamine oxidase A	Rattus norvegicus	28-33
20086011-3	2010	Now, we report that the activity and expression of cytochrome c oxidase (COX) after prolonged ischemia depend on the amount of oxygen delivered during reoxygenation.	Oxygen	127-133	cytochrome c oxidase subunit 8A	Homo sapiens	73-76
25950600-5	2015	As a key oxygen sensor, Nox4-derived H2O2 plays diverse roles in cell proliferation, migration and death.	Oxygen	9-15	NADPH oxidase 4	Homo sapiens	24-28
20437156-4	2010	Because macrophages play a major role in immune response and activated macrophages can kill microbes via oxygen-dependant mechanisms, we investigated the effect of the clpP mutation on its sensitivity to macrophage-mediated oxygen-dependant mechanisms.	Oxygen	224-230	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Mus musculus	168-172
21499767-4	2011	This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.	Oxygen	70-76	CREB regulated transcription coactivator 1	Mus musculus	97-103
21469227-1	2011	Cytochromes P450 catalyze a range of different oxygen-transfer processes including aliphatic and aromatic hydroxylation, epoxidation, and sulfoxidation reactions.	Oxygen	47-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	12-16
21486771-7	2011	During 8% O2 for 10 min, the falls in ABP and SVR were maintained, but RF, HR and MSNA waned towards baselines from the second to the tenth minute.	Oxygen	10-12	amine oxidase, copper containing 1	Rattus norvegicus	38-41
20163138-11	2010	These results indicate that the Nox4 DH domain exists in an intrinsically activated state and that electron transfer from NADPH to FAD is likely to be rate-limiting in the NADPH-dependent reduction of oxygen by holo-Nox4.	Oxygen	201-207	NADPH oxidase 4	Homo sapiens	32-36
20163138-11	2010	These results indicate that the Nox4 DH domain exists in an intrinsically activated state and that electron transfer from NADPH to FAD is likely to be rate-limiting in the NADPH-dependent reduction of oxygen by holo-Nox4.	Oxygen	201-207	NADPH oxidase 4	Homo sapiens	216-220
20160103-5	2010	Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption.	Oxygen	161-167	growth hormone releasing hormone	Mus musculus	13-17
20160103-5	2010	Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption.	Oxygen	202-208	growth hormone releasing hormone	Mus musculus	13-17
22020367-7	2011	Patients with a &gt;=30% reduction in PVR with inhaled NO and O(2) had a 53% relative reduction in mortality (Cox hazard ratio 0.47, 95% confidence interval (CI) 0.23-0.99, P=0.047), and those with a &gt;=12% reduction in mPAP with inhaled NO and O(2) had a 55% relative reduction in mortality (hazard ratio 0.45, 95% CI 0.22-0.96, P=0.038).	Oxygen	62-66	phospholipid phosphatase 1	Mus musculus	222-226
26486367-5	2015	Neuroepithelial cells (NECs), the putative oxygen chemoreceptors of fish, contain neuronal nitric oxide synthase (nNOS).	Oxygen	43-49	nitric oxide synthase 1 (neuronal)	Danio rerio	114-118
22020367-9	2011	Multivariate analysis showed that decreases in PVR and mPAP with inhaled NO and O(2) were independent predictors of survival.	Oxygen	80-84	phospholipid phosphatase 1	Mus musculus	55-59
22020367-10	2011	Reduction in PVR or mPAP during short-term administration of inhaled NO and O(2) predicts survival in PAH patients.	Oxygen	76-80	phospholipid phosphatase 1	Mus musculus	20-24
20023176-5	2010	We found that chronic oxygen-induced lung injury decreased pulmonary sGCalpha(1) and PKGI immunoreactivity in mouse pups and that exposure to a TGF-beta-neutralizing antibody prevented this reduction of sGC and PKGI protein expression.	Oxygen	22-28	transforming growth factor, beta 1	Mus musculus	144-152
21496376-3	2011	Topics covered related to COPD include childhood disadvantage factors and COPD; vitamin D deficiency and COPD; beta-blockers and COPD; corticosteroid therapy during COPD exacerbations; oxygen administration during pre-hospital transport of patients with COPD exacerbation; and prognosis of patients admitted to the hospital for COPD exacerbation.	Oxygen	185-191	COPD	Homo sapiens	26-30
26624927-2	2015	In this double-blinded, placebo-controlled study, we used blood-oxygen level dependent functional magnetic resonance imaging (fMRI) to investigate if sex-steroid hormone manipulation with a gonadotropin-releasing hormone agonist (GnRHa) influences emotional processing.	Oxygen	64-70	gonadotropin releasing hormone 1	Homo sapiens	190-220
21220430-7	2011	This suggests that Ndi1 forms a ternary complex with NADH and UQ, but the role of UQ in withdrawing an electron can be substitutable with oxygen.	Oxygen	138-144	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	19-23
20307389-7	2010	RESULTS: For glucose sensing, it was found that potassium ferricyanide with glucose dehydrogenase was ideal, featuring oxygen insensitivity, long-term stability, and a lower limit of detection of 2 muM glucose.	Oxygen	119-125	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	76-97
26252340-0	2015	Utility of Equations to Estimate Peak Oxygen Uptake and Work Rate From a 6-Minute Walk Test in Patients With COPD in a Clinical Setting.	Oxygen	38-44	COPD	Homo sapiens	109-113
20008515-0	2010	Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	152-158	RNA binding motif, single stranded interacting protein 1	Mus musculus	23-27
20010314-0	2010	Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes.	Oxygen	60-66	matrix metallopeptidase 20	Sus scrofa	102-126
20812781-7	2011	Finally, a model is proposed to describe how the redox switches on heme oxygenase-2 and the BK channel form an interconnected system that is poised to sense oxygen levels in the bloodstream and to elicit the hypoxic response when oxygen levels drop below a threshold value.	Oxygen	157-163	heme oxygenase 2	Homo sapiens	67-83
20010314-4	2010	Nine hours after resuscitation, we found a dose-dependent increase in the matrix metalloproteinase gelatinase activity in liver tissue related to percentage oxygen supply by resuscitation (100% versus 21%; p = 0.002) pointing at more extensive tissue damage.	Oxygen	157-163	matrix metallopeptidase 20	Sus scrofa	74-98
21051720-3	2011	The mice were exposed to 76% to 78% oxygen (P7-P12), to initiate oxygen-induced retinopathy (OIR).	Oxygen	65-71	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	47-50
26637092-15	2015	CONCLUSIONS: The profile of expression of SOD1 and SOD2 in cell lines SW480 and SW620 indicates differentiated response of tumor cells depending on access to oxygen.	Oxygen	158-164	superoxide dismutase 2	Homo sapiens	51-55
21306153-4	2011	Without the addition of any oxygen-evolving catalysts, we obtained photocurrents of 1.6 and 2.7 mA/cm(2) at 1.23 and 1.53 V vs RHE, respectively.	Oxygen	28-34	factor interacting with PAPOLA and CPSF1	Homo sapiens	127-130
20018872-4	2010	Exposure to low oxygen tension or treatment with the hypoxia-mimetic dimethyloxalyl glycine (DMOG) stabilized HIF-1alpha and up-regulated CTGF in human umbilical vein endothelial cells and in a murine microvascular endothelial cell line.	Oxygen	16-22	cellular communication network factor 2	Homo sapiens	138-142
26345356-2	2015	This mechanism is consistent with the suppression of R-NF2 by addition of O2 (an efficient alkyl radical scavenger) to the reaction mixture.	Oxygen	74-76	ring finger protein 2	Homo sapiens	53-58
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Oxygen	129-137	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Oxygen	129-137	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
20697415-1	2011	OBJECTIVE: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids.	Oxygen	30-36	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	41-47
21182530-2	2011	The quantum yields Phi(Delta) of singlet molecular oxygen formation of berberine, palmatine and sanguinarine are moderate in dichloromethane (0.2-0.6) and much smaller in acetonitrile or trifluoroethanol.	Oxygen	51-57	glucose-6-phosphate isomerase	Homo sapiens	19-22
21256041-4	2011	The amplitude of the K-peak that corresponds to the magnitude of damage to the oxygen evolving complex (OEC) in crr2-2 mutants was about 50% of that observed in WT plants exposed to 46 C. The damage to OEC in pgr5 mutants was relatively smaller and thus their PSII complexes were more heat tolerant.	Oxygen	79-85	proton gradient regulation 5	Arabidopsis thaliana	209-213
20204825-0	2010	Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice.	Oxygen	79-85	noggin	Homo sapiens	163-166
27774481-9	2015	Direct oxygen-dependent regulation of MALAT1 lncRNA was confirmed using isolated primary kidney epithelial cells.	Oxygen	7-13	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	38-44
19651408-6	2010	RESULTS: HMGB1 levels were inversely correlated with peak oxygen consumption (VO(2peak)) (r=-0.449, P&lt;0.001), with left ventricular ejection fraction (LVEF) (r=-0.360, P=0.003), and with HRR (r=-0.387, P&lt;0.001).	Oxygen	58-64	high mobility group box 1	Homo sapiens	9-14
21256041-8	2011	Furthermore, the experimental data predicts the onset of pseudocyclic electron transport with molecular oxygen as terminal acceptor in crr2-2 and pgr5 mutants but not in wild type Arabidopsis subjected to severe thermal-stress.	Oxygen	104-110	proton gradient regulation 5	Arabidopsis thaliana	146-150
21406623-7	2011	All germinating seeds of the kp1 and vdac3 mutants had increased oxygen consumption; the respiration balance between the cytochrome pathway and the alternative oxidase pathway was disrupted, and the ATP level was reduced.	Oxygen	65-71	voltage dependent anion channel 3	Arabidopsis thaliana	37-42
26115872-5	2015	The rate of recovery of oxygen uptake (V O2) at 2 minutes after exercise (V O2-REC2) was calculated using the difference between V O2peak and V O2 at minute 2 of recovery and expressed as a percentage of V O2peak.	Oxygen	24-30	RAD51 paralog B	Homo sapiens	79-83
20578959-7	2011	Enhanced mitochondrial oxidative stress in PON2-def mice was accompanied by significantly reduced ETC complex I + III activities, oxygen consumption, and adenosine triphosphate levels in PON2-def mice.	Oxygen	130-136	UTP25 small subunit processome component	Mus musculus	48-51
20690091-0	2010	Oxygen uptake efficiency slope correlates with brain natriuretic peptide in patients with heart failure.	Oxygen	0-6	natriuretic peptide B	Homo sapiens	47-72
19748976-4	2010	Versican and perlecan mRNA expression increased after exposure to 0.5% O(2) (hypoxia) compared with 21% O(2) (control cells).	Oxygen	71-75	versican	Homo sapiens	0-8
26115872-5	2015	The rate of recovery of oxygen uptake (V O2) at 2 minutes after exercise (V O2-REC2) was calculated using the difference between V O2peak and V O2 at minute 2 of recovery and expressed as a percentage of V O2peak.	Oxygen	41-43	RAD51 paralog B	Homo sapiens	79-83
26115872-5	2015	The rate of recovery of oxygen uptake (V O2) at 2 minutes after exercise (V O2-REC2) was calculated using the difference between V O2peak and V O2 at minute 2 of recovery and expressed as a percentage of V O2peak.	Oxygen	76-78	RAD51 paralog B	Homo sapiens	79-83
21300299-7	2011	In trained patients, decreased HMGB1 levels were significantly associated with the improvement in peak oxygen consumption (beta = -3.879, P = .003) and heart rate recovery (beta = -2.492, P = .002), and with reduced left ventricular end-diastolic volume (beta = 1.412, P = .001) and wall motion score index (beta = 1.138, P = .002).	Oxygen	103-109	high mobility group box 1	Homo sapiens	31-36
26173672-0	2015	Endothelin type A receptor inhibition normalises intrarenal hypoxia in rats used as a model of type 1 diabetes by improving oxygen delivery.	Oxygen	124-130	endothelin receptor type A	Rattus norvegicus	0-26
21057375-3	2011	Neonatal rats were exposed to 50% oxygen with brief, clustered, hypoxic (12%) episodes from birth to P14.	Oxygen	34-40	SUB1 regulator of transcription	Rattus norvegicus	101-104
19854896-1	2010	Thioredoxin reductase (encoded by trxB) protects Staphylococcus aureus against oxygen or disulfide stress and is indispensable for growth.	Oxygen	79-85	AT695_RS13830	Staphylococcus aureus	0-21
20097872-2	2010	The nonphotosynthetic mrl1 mutant of Chlamydomonas reinhardtii lacks ribulose-1,5-bisphosphate carboxylase/oxygenase, and the resulting block in electron transfer is partially compensated by redirecting electrons toward molecular oxygen via the Mehler reaction.	Oxygen	107-113	Pentatricopeptide repeat (PPR) superfamily protein	Arabidopsis thaliana	22-26
26173672-6	2015	The inhibition of ETA-Rs restored normal kidney tissue oxygen availability in the diabetic kidney by increasing renal blood flow, but did not affect oxygen consumption.	Oxygen	55-61	endothelin receptor type A	Rattus norvegicus	18-21
26173672-9	2015	CONCLUSIONS/INTERPRETATION: Acutely reduced intrarenal ETA-R signalling results in significantly improved oxygen availability in the diabetic kidney secondary to elevated renal perfusion.	Oxygen	106-112	endothelin receptor type A	Rattus norvegicus	55-60
26173672-10	2015	Thus, the beneficial effects of ETA-R inhibition on kidney function in diabetes may be due to improved intrarenal oxygen homeostasis.	Oxygen	114-120	endothelin receptor type A	Rattus norvegicus	32-37
25964099-11	2015	In response to 80% O2, expression of platelet-derived growth factor (PDGF)-A was largely reduced in cerebellar tissue and also in cultured cerebellar astrocytes.	Oxygen	19-21	platelet derived growth factor subunit A	Rattus norvegicus	69-76
19797161-7	2009	MEASUREMENTS AND MAIN RESULTS: mRNA and protein levels and activity of lysyl oxidases (Lox, LoxL1, LoxL2) were elevated in the oxygen-injured lungs of newborn mice and infants with BPD or at risk for BPD.	Oxygen	127-133	lysyl oxidase	Mus musculus	71-85
19797161-7	2009	MEASUREMENTS AND MAIN RESULTS: mRNA and protein levels and activity of lysyl oxidases (Lox, LoxL1, LoxL2) were elevated in the oxygen-injured lungs of newborn mice and infants with BPD or at risk for BPD.	Oxygen	127-133	lysyl oxidase	Mus musculus	87-90
19797161-8	2009	In oxygen-injured mouse lungs, increased TGF-beta signaling drove aberrant lox, but not loxl1 or loxl2, expression.	Oxygen	3-9	transforming growth factor, beta 1	Mus musculus	41-49
19797161-8	2009	In oxygen-injured mouse lungs, increased TGF-beta signaling drove aberrant lox, but not loxl1 or loxl2, expression.	Oxygen	3-9	lysyl oxidase	Mus musculus	75-78
19797161-9	2009	Lox expression was also increased in oxygen-injured fibroblasts and pulmonary artery smooth muscle cells.	Oxygen	37-43	lysyl oxidase	Mus musculus	0-3
21250878-1	2011	A new high oxygen affinity hemoglobin (Hb) variant, Hb Nebraska [beta86(F2)Ala Ile, GCC&gt;ATC; HGVS: HBB: c.259G&gt;A;260C&gt;T] is reported.	Oxygen	11-17	guanylate cyclase 2C	Homo sapiens	84-87
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	28-34	serpin family F member 1	Rattus norvegicus	126-130
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	28-34	serpin family F member 1	Rattus norvegicus	148-152
26011492-6	2015	We found that Tollip expression was significantly increased in I/R-challenged brain tissue of humans, mice and rats in vivo and in primary neurons subjected to oxygen and glucose deprivation in vitro, indicating the involvement of Tollip in I/R injury.	Oxygen	160-166	toll interacting protein	Homo sapiens	14-20
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	48-54	serpin family F member 1	Rattus norvegicus	126-130
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	48-54	serpin family F member 1	Rattus norvegicus	148-152
21738387-12	2011	CONCLUSIONS: Increased expression levels of VEGF and PEDF are associated with older postnatal day age or with exposure to fluctuations in oxygen in the 50/10 oxygen-induced retinopathy model compared to RA.	Oxygen	138-144	serpin family F member 1	Rattus norvegicus	53-57
21738387-12	2011	CONCLUSIONS: Increased expression levels of VEGF and PEDF are associated with older postnatal day age or with exposure to fluctuations in oxygen in the 50/10 oxygen-induced retinopathy model compared to RA.	Oxygen	158-164	serpin family F member 1	Rattus norvegicus	53-57
22174785-0	2011	Skeletal muscle-specific expression of PGC-1alpha-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake.	Oxygen	122-128	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	39-49
22174785-9	2011	Overexpression of PGC-1alpha-b promoted mitochondrial biogenesis 4-fold, increased the expression of fatty acid transporters, enhanced angiogenesis in skeletal muscle 1.4 to 2.7-fold, and promoted exercise capacity (expressed by maximum speed) by 35% and peak oxygen uptake by 20%.	Oxygen	260-266	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	18-28
20120704-5	2009	At the end stage of COPD long-term oxygen therapy lung volume reduction surgery and lung transplantation should be considered.	Oxygen	35-41	COPD	Homo sapiens	20-24
19846781-2	2009	The membrane anion transport protein (band 3 or AE1) is thought to facilitate this process by binding glycolytic enzymes (GEs) and inhibiting their activity in an oxygen-dependent manner.	Oxygen	163-169	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	48-51
19412660-1	2009	Nitric oxide (NO) is known to regulate mitochondrial respiration, especially during metabolic stress and disease, by nitrosation of the mitochondrial electron transport chain (ETC) complexes (irreversible) and by a competitive binding at O2 binding site of cytochrome c oxidase (CcO) in complex IV (reversible).	Oxygen	238-240	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	257-277
19412660-1	2009	Nitric oxide (NO) is known to regulate mitochondrial respiration, especially during metabolic stress and disease, by nitrosation of the mitochondrial electron transport chain (ETC) complexes (irreversible) and by a competitive binding at O2 binding site of cytochrome c oxidase (CcO) in complex IV (reversible).	Oxygen	238-240	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	279-282
26289593-6	2015	Preliminary in vitro experiments with C6 Glioma cells treated with [Ir(ppy)2()][PF6], show that the complex is an efficient sensitizer for triplet oxygen, producing cytotoxic singlet oxygen ((1)O2) by two-photon excitation at 740 nm resulting in photodynamic effects that lead to localised cell damage and death.	Oxygen	147-153	sperm associated antigen 17	Homo sapiens	80-83
19782385-5	2009	The carbon contents increased from 43.34% to 51.90% and 43.06% to 53.26% while the oxygen contents decreased from 46.39% to 36.76% and 49.76% to 40.03% for PF1-PF4 and NF1-NF4, respectively.	Oxygen	83-89	PHD finger protein 12	Homo sapiens	156-163
22028798-0	2011	Proteases inhibition assessment on PC12 and NGF treated cells after oxygen and glucose deprivation reveals a distinct role for aspartyl proteases.	Oxygen	68-74	nerve growth factor	Rattus norvegicus	44-47
26289593-6	2015	Preliminary in vitro experiments with C6 Glioma cells treated with [Ir(ppy)2()][PF6], show that the complex is an efficient sensitizer for triplet oxygen, producing cytotoxic singlet oxygen ((1)O2) by two-photon excitation at 740 nm resulting in photodynamic effects that lead to localised cell damage and death.	Oxygen	191-196	sperm associated antigen 17	Homo sapiens	80-83
21058400-2	2011	Ngb can reversibly bind small ligands such as O2 and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand.	Oxygen	46-48	neuroglobin	Mus musculus	0-3
19749173-1	2009	The mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adaptation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and nutritional conditions are suboptimal for fungal growth.	Oxygen	171-177	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	14-55
25950931-2	2015	The streptavidin functionalized zirconium-porphyrin MOF (PCN-222@SA) was prepared as signal nanoprobe via covalent method and demonstrated high electrocatalysis for O2 reduction.	Oxygen	165-167	lysine acetyltransferase 8	Homo sapiens	52-55
19749173-1	2009	The mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adaptation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and nutritional conditions are suboptimal for fungal growth.	Oxygen	171-177	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	57-62
19749173-3	2009	We generated mutants susceptible to low oxygen and identified six genes that play a role in the SREBP pathway.	Oxygen	40-46	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	96-101
19749173-9	2009	These findings suggest that the SREBP pathway is highly conserved in C. neoformans and it serves as an important link between sterol biosynthesis, oxygen sensing, CoCl(2) sensitivity, and virulence in C. neoformans.	Oxygen	147-153	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	32-37
21804324-4	2011	We have found that apelin/APJ system is involved in not only physiological but also pathological retinal angiogenesis using a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	141-147	apelin	Mus musculus	19-25
26113245-8	2015	A significant and positive correlation between admission PAPP-A levels and pneumonia severity index; confusion, oxygen saturation, respiratory rate, blood pressure, and age 75 years or older; and confusion, urea, respiratory rate, blood pressure, and age older than 65 years scores was found (r = .440, P &lt; .001; r = .395, P &lt; .001; and r = .359, P &lt; .001, respectively).	Oxygen	112-118	pappalysin 1	Homo sapiens	57-63
20833275-6	2010	We envision oxygen-sensing in carotid body chemoreceptor cells as a process initiated at the level of plasma membrane and performed by a hemoprotein, which might be NOX4 or a hemoprotein not yet chemically identified.	Oxygen	12-18	NADPH oxidase 4	Homo sapiens	165-169
19692634-6	2009	Anti-PECAM/catalase also reduced alveolar edema and attenuated decline in arterial oxygen in mice that underwent unilateral lung ischemia/reperfusion, whereas anti-PECAM/SOD was not effective, implying the key role of H(2)O(2) in tissue damage in this pathology.	Oxygen	83-89	platelet/endothelial cell adhesion molecule 1	Mus musculus	5-10
26051930-7	2015	In cultured rat retinal ganglion cells (RGC-5), SBDP120 elevation occurred with caspase-3 activation following oxygen as well as serum deprivation, suggestive of SBDP120 formation in stressful conditions with and without apparent neuronal death.	Oxygen	111-117	caspase 3	Rattus norvegicus	80-89
19641936-6	2009	Exposure to 1% O2 or treatment with the hypoxia-mimetic agent cobalt chloride (CoCl2) significantly suppressed the expression of MSR1 mRNA, accompanied by a markedly increase in levels of nuclear HIF-1alpha protein.	Oxygen	15-17	macrophage scavenger receptor 1	Mus musculus	129-133
19893619-0	2009	Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.	Oxygen	93-99	microRNA 20b	Homo sapiens	37-44
19893619-3	2009	Here, we show that miR-20b plays an important role in fine-tuning the adaptation of tumor cells to oxygen concentration.	Oxygen	99-105	microRNA 20b	Homo sapiens	19-26
19893619-8	2009	The differential expression of miR-20b has important biological significance in tumor cells, either enhancing the growth or favoring the survival of tumor cells upon the oxygen supply.	Oxygen	170-176	microRNA 20b	Homo sapiens	31-38
19893619-9	2009	Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations.	Oxygen	185-191	microRNA 20b	Homo sapiens	71-78
20959444-1	2010	In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply.	Oxygen	217-223	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	149-154
20959444-1	2010	In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply.	Oxygen	217-223	SREBF chaperone	Homo sapiens	160-164
21128791-4	2010	BPAEC cultured in 20% oxygen grow better when they are transiently transfected with either manganese superoxide dismutase (MnSOD) or copper zinc superoxide dismutase (CuZnSOD) and exhibit improved survival after irradiation (0.5-10 Gy).	Oxygen	22-28	superoxide dismutase [Mn], mitochondrial	Bos taurus	91-121
21128791-4	2010	BPAEC cultured in 20% oxygen grow better when they are transiently transfected with either manganese superoxide dismutase (MnSOD) or copper zinc superoxide dismutase (CuZnSOD) and exhibit improved survival after irradiation (0.5-10 Gy).	Oxygen	22-28	superoxide dismutase [Mn], mitochondrial	Bos taurus	123-128
21128791-5	2010	Furthermore, X irradiation of BPAEC grown in 20% oxygen results in very diffuse colony formation, which is completely ameliorated by either growth in 3% oxygen or overexpression of MnSOD.	Oxygen	49-55	superoxide dismutase [Mn], mitochondrial	Bos taurus	181-186
26318663-8	2015	Using siRNA against AMPK as well as AMPK deficient cells, autophagy stimulation by 1% O2 was shown to be AMPK-independent.	Oxygen	86-88	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24
21057730-3	2010	CD73 activity is primarily regulated at the level of transcription in response to the oxygen-sensing transcription factor HIF1, and its tissue-specific expression correlates negatively with oxygen tension.	Oxygen	86-92	5'-nucleotidase ecto	Homo sapiens	0-4
21057730-3	2010	CD73 activity is primarily regulated at the level of transcription in response to the oxygen-sensing transcription factor HIF1, and its tissue-specific expression correlates negatively with oxygen tension.	Oxygen	190-196	5'-nucleotidase ecto	Homo sapiens	0-4
19847308-4	2009	The observation that Mps1- and Polo-associated filaments reappear in the same locations through multiple cycles of oxygen deprivation demonstrates that underlying structural components of the filaments must still be present during normoxic conditions.	Oxygen	115-121	Monopolar spindle 1	Drosophila melanogaster	21-25
19847308-4	2009	The observation that Mps1- and Polo-associated filaments reappear in the same locations through multiple cycles of oxygen deprivation demonstrates that underlying structural components of the filaments must still be present during normoxic conditions.	Oxygen	115-121	polo	Drosophila melanogaster	31-35
26574473-2	2015	The binding of the von Hippel-Lindau tumor suppressor protein (pVHL)-ElonginC-ElonginB complex (VCB) to HIF-1alpha is highly selective for the trans-4-hydroxylation form of when Pro564 in the C-terminal oxygen-dependent degradation domain (ODDD) of HIF-1alpha.	Oxygen	203-209	von Hippel-Lindau tumor suppressor	Homo sapiens	63-67
19631610-0	2009	Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.	Oxygen	9-15	egl-9 family hypoxia inducible factor 2	Homo sapiens	118-122
19657056-13	2009	These results suggest that O2 binding with NOX4 per se controls TASK-1 activity.	Oxygen	27-29	NADPH oxidase 4	Homo sapiens	43-47
21092040-1	2010	The aim of this study is to evaluate the effect of temperature on cerebral oxygen metabolism at total body flow bypass and antegrade cerebral perfusion (ACP).	Oxygen	75-81	CPAT1	Homo sapiens	153-156
21092040-17	2010	ACP provided sufficient oxygen to the brain at a total body flow rate of 100mL/kg/min at deep hypothermia.	Oxygen	24-30	CPAT1	Homo sapiens	0-3
21092040-18	2010	Although ACP provided minimum oxygenation to the brain which met the oxygen requirement, oxygen metabolism was altered during ACP at moderate hypothermia.	Oxygen	30-36	CPAT1	Homo sapiens	9-12
25896562-1	2015	The terminal respiratory enzyme cytochrome c oxidase (CcO) reduces molecular oxygen to water, and pumps protons across the inner mitochondrial membrane, or the plasma membrane of bacteria.	Oxygen	77-83	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	32-52
21314602-4	2010	Accordingly, the catalase activity of bovine oxidase may be explained by H2O2 procession in the oxygen-reducing center of the enzyme yielding superoxide radicals.	Oxygen	96-102	catalase	Bos taurus	17-25
20967268-7	2010	UCP2 accounted for a remarkable 37% of the resting cellular oxygen consumption indicating that the MX2 cells are functionally reliant on this protein.	Oxygen	60-66	uncoupling protein 2	Homo sapiens	0-4
19482023-4	2009	ICAM-1 deficient mice as well as their respective wild-type controls were exposed to 75% oxygen from postnatal day 7 to day 12.	Oxygen	89-95	intercellular adhesion molecule 1	Mus musculus	0-6
25896562-1	2015	The terminal respiratory enzyme cytochrome c oxidase (CcO) reduces molecular oxygen to water, and pumps protons across the inner mitochondrial membrane, or the plasma membrane of bacteria.	Oxygen	77-83	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	54-57
25896562-2	2015	A two-subunit CcO harbors all the elements necessary for oxygen reduction and proton pumping.	Oxygen	57-63	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	14-17
20889127-4	2010	miR-378(*) performs this function by inhibiting the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in tricarboxylic acid cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation.	Oxygen	181-187	estrogen related receptor gamma	Homo sapiens	90-98
26037477-10	2015	In summary, our data signify a novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia.	Oxygen	58-64	von Hippel-Lindau tumor suppressor	Homo sapiens	124-127
20707865-5	2010	The hypoxia-inducible transcription factor ArcA, acting independently of acetate metabolism, is also required for maximum lifespan extension in the lipA and lpdA mutants, indicating that these mutations promote entry into a mode normally associated with a low-oxygen environment.	Oxygen	260-266	arginine deiminase	Escherichia coli	43-47
21029313-4	2010	HIF activity is regulated by the von Hippel-Lindau (Vhl) protein, which targets the HIFalpha subunit for proteasomal degradation in the presence of oxygen.	Oxygen	148-154	von Hippel-Lindau tumor suppressor	Homo sapiens	33-50
21029313-4	2010	HIF activity is regulated by the von Hippel-Lindau (Vhl) protein, which targets the HIFalpha subunit for proteasomal degradation in the presence of oxygen.	Oxygen	148-154	von Hippel-Lindau tumor suppressor	Homo sapiens	52-55
19679834-4	2009	METHODS AND RESULTS: Hypoxia (10% oxygen) induced the mobilization of EPCs in wild-type (WT) and Nox1 but not in Nox2 knockout (Nox2(y/-)) mice.	Oxygen	34-40	NADPH oxidase 1	Mus musculus	97-101
19693014-5	2009	Rac1 mutants were fused to the photoreactive LOV (light oxygen voltage) domain from phototropin, sterically blocking Rac1 interactions until irradiation unwound a helix linking LOV to Rac1.	Oxygen	56-62	Rac family small GTPase 1	Mus musculus	0-4
19693014-5	2009	Rac1 mutants were fused to the photoreactive LOV (light oxygen voltage) domain from phototropin, sterically blocking Rac1 interactions until irradiation unwound a helix linking LOV to Rac1.	Oxygen	56-62	Rac family small GTPase 1	Mus musculus	117-121
19693014-5	2009	Rac1 mutants were fused to the photoreactive LOV (light oxygen voltage) domain from phototropin, sterically blocking Rac1 interactions until irradiation unwound a helix linking LOV to Rac1.	Oxygen	56-62	Rac family small GTPase 1	Mus musculus	117-121
19574491-4	2009	This was tested in bilateral, cranially based dorsal skin flaps in mice treated with a HbV solution with an oxygen affinity that was increased to a P(50) (partial oxygen tension at which the hemoglobin becomes 50% saturated with oxygen) of 9 mmHg.	Oxygen	108-114	dynactin 2	Mus musculus	148-153
26121178-0	2015	Improve First-Cycle Efficiency and Rate Performance of Layered-Layered Li1.2Mn0.6Ni0.2O2 Using Oxygen Stabilizing Dopant.	Oxygen	95-101	transglutaminase 1	Homo sapiens	71-74
19444132-10	2009	Moreover, in cyanotic defects, BNP showed a significant correlation with O2 saturation (rho=0.204 P=0.0128).	Oxygen	73-75	natriuretic peptide B	Homo sapiens	31-34
19546213-2	2009	Whereas PHD1 and PHD3 proteolysis has been shown to be regulated by Siah2 ubiquitin E3 ligase-mediated polyubiquitylation and proteasomal destruction, protein regulation of the main oxygen sensor responsible for hypoxia-inducible factor alpha regulation, PHD2, remained unknown.	Oxygen	182-188	egl-9 family hypoxia inducible factor 2	Homo sapiens	8-12
26203084-8	2015	When photoreceptors in the detached retina were removed from the primary source of oxygen and nutrients (choroidal vascular bed), the retina became hypoxic, leading to an up-regulation of complement factor B, a key mediator of the alternative pathway.	Oxygen	83-89	complement factor B	Homo sapiens	188-207
19542232-7	2009	SOD1 molecules that are activated without CCS exhibit disulfide oxidation in vivo without oxygen and under copper-depleted conditions.	Oxygen	90-96	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	0-4
19542232-8	2009	The strict requirement for copper, oxygen, and CCS in disulfide bond oxidation appears exclusive to yeast SOD1, and we find that a unique proline at position 144 in yeast SOD1 is responsible for this disulfide effect.	Oxygen	35-41	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	171-175
26061285-2	2015	For Fe-MOF-74, we here find using density functional calculations that the O2 and C2H4 adsorptions result in the ferromagnetic (FM) and antiferromagnetic (AFM) orderings along the 1D chain of an hexagonal MOF framework, respectively, while their adsorption energies, pi-complexation, and geometrical changes are all similar upon binding.	Oxygen	75-77	lysine acetyltransferase 8	Homo sapiens	7-10
19542232-9	2009	CCS-dependent and -independent pathways also exhibit differential requirements for molecular oxygen.	Oxygen	93-99	copper chaperone for superoxide dismutase	Homo sapiens	0-3
19542232-10	2009	CCS activation of SOD1 requires oxygen, whereas the CCS-independent pathway is able to activate SOD1s even under anaerobic conditions.	Oxygen	32-38	copper chaperone for superoxide dismutase	Homo sapiens	0-3
19542232-10	2009	CCS activation of SOD1 requires oxygen, whereas the CCS-independent pathway is able to activate SOD1s even under anaerobic conditions.	Oxygen	32-38	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	18-22
26061285-2	2015	For Fe-MOF-74, we here find using density functional calculations that the O2 and C2H4 adsorptions result in the ferromagnetic (FM) and antiferromagnetic (AFM) orderings along the 1D chain of an hexagonal MOF framework, respectively, while their adsorption energies, pi-complexation, and geometrical changes are all similar upon binding.	Oxygen	75-77	lysine acetyltransferase 8	Homo sapiens	205-208
18830683-4	2009	In the SAMP1-ExRes group, there was a significant increase in oxygen consumption and skeletal muscle mRNA levels of mitochondrial function-related enzymes.	Oxygen	62-68	transmembrane protein 201	Mus musculus	7-12
25956063-8	2015	The synthetic lethality of sod1Delta Pma1-T912D cells is suppressed by growing cells under low oxygen conditions or by treatments with manganese-based antioxidants.	Oxygen	95-101	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	37-41
19389832-8	2009	Oxygen consumption, an indirect measure of the metabolic rate, was markedly increased in Inhba(BK/BK) mice, and polarographic analysis of liver mitochondria revealed an increase in ADP-independent oxygen consumption, consistent with constitutive uncoupling of the inner mitochondrial membrane.	Oxygen	0-6	inhibin beta-A	Mus musculus	89-94
26205723-1	2015	According to the data of reverse-transcription-PCR, long-term culturing of multipotent mesenchymal stromal cells from human adipose tissue at 1% O2 (vs. standard 20% O2) led to a decrease in HIF-1alpha gene expression, while no changes in this parameter were revealed at 5% O2.	Oxygen	166-168	angiotensin II receptor type 1	Homo sapiens	139-147
19425817-8	2009	The oxygen-to-carbon atomic ratio decreased from 0.29, 0.12, and 0.07 for the original lignite (XF0), fusinite (HZ0), and lopinite (LP0) samples, respectively, to 0.07, 0.06, and 0.04 for XF7, HZ7, and LP7, respectively, that underwent the highest temperature treatment.	Oxygen	4-10	ribosomal protein lateral stalk subunit P0	Homo sapiens	132-135
25472856-2	2015	METHODS: ROP was induced by exposing mice to 75% oxygen from postnatal day 7 (P7 ) to P12 , then to room air from P12 to P17 .	Oxygen	49-55	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	86-89
26218904-2	2015	METHODS: Oxygen-induced retinopathy was induced in C57BL/6J mice by exposing postnatal day seven (P7) pups to 75% oxygen and then returning them to room air at P12.	Oxygen	9-15	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	160-163
19947271-0	2009	[Investigation on the changes of dependent signal on the amplitude of low frequency fluctuations at blood oxygen level in brain after acupuncture Neiguan (PC 6)].	Oxygen	106-112	proprotein convertase subtilisin/kexin type 5	Homo sapiens	155-159
19650992-7	2009	RESULTS: Compared with the control group, the 3% and 5% oxygen treatment groups significantly increased the adhesion, migration and invasion abilities of K562 cells (p&lt;0.05 or &lt;0.01), and up-regulated the protein level of HIF-1alpha and the mRNA levels of HIF-1alpha,VEGF, MMP-9 and MMP-2 (p&lt;0.05 or 0.01).	Oxygen	56-62	matrix metallopeptidase 2	Homo sapiens	289-294
25953442-11	2015	CONCLUSIONS: We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC.	Oxygen	84-90	osteoglycin	Homo sapiens	37-40
19328848-5	2009	OH-Cbl and CN(2)-Cbi prevented binding of the oxygen analog carbon monoxide (CO) to the reduced NOS1 and NOS2 heme active site.	Oxygen	46-52	nitric oxide synthase 1, neuronal	Mus musculus	96-100
19325183-6	2009	The rate and E(a) of the slow reaction of quinol with oxygen that are observed after cytochrome b is reduced were unaffected by the E272Q substitution, whereas the Y185F mutation modified only its rate.	Oxygen	54-60	cytochrome b	Saccharomyces cerevisiae S288C	85-97
19286940-9	2009	Based on these data, we propose a model in which deoxyhemoglobin binding to AE-1 inhibits nitrite export under low oxygen tensions allowing for the coupling between deoxygenation and nitrite reduction to NO along the arterial-to-venous gradient.	Oxygen	115-121	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	76-80
25953442-11	2015	CONCLUSIONS: We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC.	Oxygen	84-90	Zic family member 1	Homo sapiens	42-46
26170654-10	2015	Among patients with low transcutaneous oxygen saturation during exacerbations, PaO2 (partial oxygen pressure) correlated with concentrations of MPO and NE protein and neutrophils in a negative manner.	Oxygen	39-45	elastase, neutrophil expressed	Homo sapiens	152-154
19566295-5	2009	Parameters micros and g are significantly influenced by the SAT O(2)-induced absorption changes.	Oxygen	64-68	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	60-63
26170654-10	2015	Among patients with low transcutaneous oxygen saturation during exacerbations, PaO2 (partial oxygen pressure) correlated with concentrations of MPO and NE protein and neutrophils in a negative manner.	Oxygen	93-99	elastase, neutrophil expressed	Homo sapiens	152-154
19299628-8	2009	RESULTS: Methazolamide and melatonin inhibit oxygen/glucose deprivation-induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors, pro-IL-1beta processing, and activation of caspase-1 and -3 in primary cerebrocortical neurons.	Oxygen	45-51	caspase 1	Mus musculus	211-227
26066988-1	2015	Ratiometric molecular probes RP1 and RP2 consisting of a blue fluorescent coumarin and a red phosphorescent cationic iridium complex connected by a tetra- or octaproline linker, respectively, were designed and synthesized for sensing oxygen levels in living cells.	Oxygen	234-240	RP1 axonemal microtubule associated	Homo sapiens	29-32
19262507-4	2009	GLB-5 acts with the atypical soluble guanylate cyclases, which are a different type of oxygen binding protein, to tune the dynamic range of oxygen-sensing neurons close to atmospheric (21%) concentrations.	Oxygen	140-146	GLOBIN domain-containing protein	Caenorhabditis elegans	0-5
26066988-4	2015	The ratios (R(I) = (I(p)/I(f))) between the phosphorescence (I(p)) and fluorescence (I(f)) intensities showed excellent oxygen responses; the ratio of R(I) under degassed and aerated conditions ( R(I)(0) was 20.3 and 19.6 for RP1 and RP2.	Oxygen	120-126	RP1 axonemal microtubule associated	Homo sapiens	226-229
19262507-6	2009	The soluble guanylate cyclase GCY-35 is required for high oxygen to activate the neurons; GLB-5 provides inhibitory input when oxygen decreases below 21%.	Oxygen	127-133	GLOBIN domain-containing protein	Caenorhabditis elegans	90-95
19262507-8	2009	The effect of the glb-5 gene on oxygen sensing and foraging is modified by the naturally variable neuropeptide receptor npr-1 (refs 4, 5), providing insights into how polygenic variation reshapes neural circuit function.	Oxygen	32-38	GLOBIN domain-containing protein	Caenorhabditis elegans	18-23
25982659-7	2015	They also observed association of PPM1G hypermethylation with increased blood-oxygen-level-dependent response in the right subthalamic nucleus during an impulsiveness task.	Oxygen	78-84	protein phosphatase, Mg2+/Mn2+ dependent 1G	Homo sapiens	34-39
25701705-5	2015	Using recombinant enzymes and isolated permeabilized cardiac mitochondria, we show that two normally antioxidant matrix NADPH reductases, glutathione reductase and thioredoxin reductase, generate H2O2 by leaking electrons from their reduced flavoprotein to O2 when electron flow is impaired by inhibitors or because of limited availability of their natural electron acceptors, GSSG and oxidized thioredoxin.	Oxygen	198-200	glutathione-disulfide reductase	Homo sapiens	138-159
19242346-13	2009	Inhibition of neuraminidase may represent a new therapeutic option to ameliorate RBC rheology and perhaps oxygen delivery to the cells.	Oxygen	106-112	neuraminidase 1	Homo sapiens	14-27
26063577-0	2015	Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.	Oxygen	13-19	TNF receptor superfamily member 11b	Homo sapiens	85-100
20049704-2	2009	The oxygen-dependent degradation of HIF-alpha is carried out by the von Hippel-Lindau (VHL) protein-containing E3 that directly binds and ubiquitylates HIF-alpha for subsequent proteasomal destruction.	Oxygen	4-10	von Hippel-Lindau tumor suppressor	Homo sapiens	68-85
20049704-2	2009	The oxygen-dependent degradation of HIF-alpha is carried out by the von Hippel-Lindau (VHL) protein-containing E3 that directly binds and ubiquitylates HIF-alpha for subsequent proteasomal destruction.	Oxygen	4-10	von Hippel-Lindau tumor suppressor	Homo sapiens	87-90
20049704-5	2009	In the present study, we describe the bioengineering of VHL protein that removes the oxygen constraint in the recognition of HIF-alpha while preserving its E3 enzymatic activity.	Oxygen	85-91	von Hippel-Lindau tumor suppressor	Homo sapiens	56-59
25671767-4	2015	We have recently identified the SAM-domain containing protein Anks3 as a potential ANKS6/NPHP16-interacting protein, and report now that Anks3 interacts with several NPHPs as well as with Bicc1 and the oxygen-sensitive asparaginyl hydroxylase HIF1AN.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha inhibitor	Danio rerio	243-249
19372578-0	2009	Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.	Oxygen	12-18	prominin 1	Homo sapiens	70-75
19372578-3	2009	Growing CD133(+) cells sorted from three GB neurosphere cultures at 7% O(2) reduced their doubling time and increased the self-renewal potential as reflected by clonogenicity.	Oxygen	71-75	prominin 1	Homo sapiens	8-13
25796222-0	2015	Near infrared radiation protects against oxygen-glucose deprivation-induced neurotoxicity by down-regulating neuronal nitric oxide synthase (nNOS) activity in vitro.	Oxygen	41-47	nitric oxide synthase 1	Homo sapiens	109-139
19372578-5	2009	As compared with 20%, growth at 7% oxygen resulted in an increase in the expression levels of the neural stem cell markers CD133 and nestin as well as the stem cell markers Oct4 and Sox2.	Oxygen	35-41	prominin 1	Homo sapiens	123-128
19403028-10	2009	However, the migration and invasion of SMMC-7721 cells transfected with pshRNA-FAK was decreased in 1% O2 (P&lt;0.05).	Oxygen	103-105	protein tyrosine kinase 2	Homo sapiens	79-82
25796222-0	2015	Near infrared radiation protects against oxygen-glucose deprivation-induced neurotoxicity by down-regulating neuronal nitric oxide synthase (nNOS) activity in vitro.	Oxygen	41-47	nitric oxide synthase 1	Homo sapiens	141-145
25767141-2	2015	In this study, we demonstrate for the first time that human spermatozoa possess interleukin-induced gene 1 (IL4I1), an l-amino acid oxidase (LAAO) which is capable of generating ROS on exposure to aromatic amino acids in the presence of oxygen.	Oxygen	237-243	interleukin 4 induced 1	Homo sapiens	108-113
19000660-5	2009	It has been our hypothesis that in ALDH3 this is a beneficial interaction, enabling the "proximal" Lys to interact with the carbonyl oxygen of the peptide bond with the catalytic Cys, allowing the Cys amide N to transiently protonate the tetrahedral intermediate.	Oxygen	133-139	aldehyde dehydrogenase 3 family member A1	Homo sapiens	35-40
25767141-2	2015	In this study, we demonstrate for the first time that human spermatozoa possess interleukin-induced gene 1 (IL4I1), an l-amino acid oxidase (LAAO) which is capable of generating ROS on exposure to aromatic amino acids in the presence of oxygen.	Oxygen	237-243	interleukin 4 induced 1	Homo sapiens	119-139
19318315-6	2009	The expression of some differentiation markers (CD34, CD13 and CD41) on haematopoietic cells in co-cultures also depends upon the oxygen concentration.	Oxygen	130-136	alanyl aminopeptidase, membrane	Homo sapiens	54-58
19092722-0	2009	Oxygen-induced retinopathy in mice: amplification by neonatal IGF-I deficit and attenuation by IGF-I administration.	Oxygen	0-6	insulin-like growth factor 1	Mus musculus	62-67
19092722-0	2009	Oxygen-induced retinopathy in mice: amplification by neonatal IGF-I deficit and attenuation by IGF-I administration.	Oxygen	0-6	insulin-like growth factor 1	Mus musculus	95-100
19092722-3	2009	We further explored the link between IGF-I and oxygen-induced retinopathy (OIR).	Oxygen	47-53	insulin-like growth factor 1	Mus musculus	37-42
25767141-2	2015	In this study, we demonstrate for the first time that human spermatozoa possess interleukin-induced gene 1 (IL4I1), an l-amino acid oxidase (LAAO) which is capable of generating ROS on exposure to aromatic amino acids in the presence of oxygen.	Oxygen	237-243	interleukin 4 induced 1	Homo sapiens	141-145
25918408-10	2015	Inhibition of OGT or OGA activity within neonatal rat cardiomyocytes significantly affects energy production, mitochondrial membrane potential, and mitochondrial oxygen consumption.	Oxygen	162-168	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	14-17
19164785-7	2009	This change was exerted at the transcriptional level because the inhibition of nuclear factor kappa B translocation by small interfering RNA against p65 and SN-50 prevented oxygen and glucose deprivation-induced NCX1 upregulation.	Oxygen	173-179	RELA proto-oncogene, NF-kB subunit	Homo sapiens	149-152
25918408-10	2015	Inhibition of OGT or OGA activity within neonatal rat cardiomyocytes significantly affects energy production, mitochondrial membrane potential, and mitochondrial oxygen consumption.	Oxygen	162-168	O-GlcNAcase	Rattus norvegicus	21-24
25765152-6	2015	A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site.	Oxygen	86-92	FAD dependent oxidoreductase domain containing 1	Homo sapiens	22-29
18786823-1	2009	This paper presents the integrated removal of carbon (measured as chemical oxygen demand i.e. COD) and NO(x)-N by sequentially adapted sludge, studied in an airlift reactor (ALR).	Oxygen	75-81	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	94-97
18786823-8	2009	The reduction of COD was significantly faster in the presence of NO(x)-N and was attributed to the availability of oxygen from NO(x)-N and distinct conditions in the reactor.	Oxygen	115-121	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	17-20
25618295-5	2015	Transient hypoxic culture (2 weeks at 5 % O2 followed by 1 week at 21 % O2) of hESC-EBs in medium conditioned with primary chondrocytes up-regulated the expression of SOX9 and suppressed pluripotent markers OCT4 and NANOG.	Oxygen	72-74	SRY-box transcription factor 9	Homo sapiens	167-171
18844219-3	2009	When cells were subjected to hypoxia (1% O2), the expression of HSP70-2 had a significant increase in cancer cells.	Oxygen	41-43	heat shock protein family A (Hsp70) member 2	Homo sapiens	64-71
25648699-5	2015	METHODS AND RESULTS: The loss of CAST, which is ensured by several growth factor classes, was detectable in neovessels in murine allograft tumors, some human malignant tissues, and oxygen-induced retinopathy lesions in mice.	Oxygen	181-187	calpastatin	Mus musculus	33-37
18952043-1	2009	The human hypoxia-inducible factor prolyl hydroxylases 1, 2, and 3 (HIF-PHD1, -2, and -3) are thought to act as proximal sensors of cellular hypoxia by virtue of their mechanism-based dependence on molecular oxygen.	Oxygen	208-214	egl-9 family hypoxia inducible factor 2	Homo sapiens	10-66
25648699-6	2015	EC-specific transgenic introduction of CAST caused downregulation of JAK/STAT signals, upregulation of SOCS3 expression, and depletion of vascular endothelial growth factor (VEGF)-C, thereby counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice.	Oxygen	276-282	calpastatin	Mus musculus	39-43
19275614-10	2009	Some oxygen heterocycles, coumarines and chromenes, have also drawn attention as MIF inhibitors.	Oxygen	5-11	macrophage migration inhibitory factor	Homo sapiens	81-84
25801957-1	2015	At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O2 to the mitochondria.	Oxygen	78-80	myoglobin	Rattus norvegicus	32-41
18703992-6	2009	Prostaglandins D2, E2, and F2alpha were increased in the tissues from mouse pups exposed to &gt;95% O2 at 7 d indicating a differential expression of cyclooxygenase-2 products.	Oxygen	100-102	prostaglandin-endoperoxide synthase 2	Mus musculus	150-166
25801957-1	2015	At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O2 to the mitochondria.	Oxygen	78-80	myoglobin	Rattus norvegicus	43-45
25801957-4	2015	The purpose of this study was, therefore, to determine the effect of endurance training on O2 saturation of Mb (SmbO2) and PmbO2 kinetics during muscle contraction.	Oxygen	91-93	myoglobin	Rattus norvegicus	108-110
25785990-0	2015	Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular endothelial growth factor receptor Flk-1.	Oxygen	45-51	kinase insert domain protein receptor	Mus musculus	154-159
18948262-12	2008	Such variation in mechanisms of copper activation of SOD1 could reflect evolutionary responses to unique oxygen and/or copper environments faced by divergent species.	Oxygen	105-111	Superoxide dismutase 1	Drosophila melanogaster	53-57
25466899-7	2015	Oxygen uptake, voluntary physical activity, and exercise capacity were significantly reduced in TWEAK-Tg mice compared with controls.	Oxygen	0-6	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	96-101
18719022-3	2008	Energy expenditure (oxygen and food consumption) is elevated in Thra-0/0 mice reared at room temperature.	Oxygen	20-26	thyroid hormone receptor alpha	Mus musculus	64-68
25514442-5	2015	Increased nitration of both IGF-I and IGF-R1 was evident in 60% O2-exposed lungs, which was reversible by concurrent treatment with a peroxynitrite decomposition catalyst.	Oxygen	64-66	insulin-like growth factor 1 receptor	Rattus norvegicus	38-44
25514442-13	2015	We conclude that peroxynitrite contributes to the impaired alveologenesis observed following the exposure of neonatal rats to 60% O2 both by preventing binding of IGF-I to the IGF-R1, secondary to nitration of the IGF-R1, and by causing an up-regulation of the growth inhibitor, TGFbeta1.	Oxygen	130-132	insulin-like growth factor 1 receptor	Rattus norvegicus	176-182
25514442-13	2015	We conclude that peroxynitrite contributes to the impaired alveologenesis observed following the exposure of neonatal rats to 60% O2 both by preventing binding of IGF-I to the IGF-R1, secondary to nitration of the IGF-R1, and by causing an up-regulation of the growth inhibitor, TGFbeta1.	Oxygen	130-132	insulin-like growth factor 1 receptor	Rattus norvegicus	214-220
18937446-4	2008	Solutions of [(L1)Mn(II)-THF]- in THF are oxidized by dioxygen to afford [(L1re-1)Mn(III)-(O)2-Mn(III)(L1 re-1)]2-as the major product.	Oxygen	54-62	LINE1 retrotransposable element 1	Homo sapiens	75-81
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	44-50	myoglobin	Bos taurus	29-38
18937446-4	2008	Solutions of [(L1)Mn(II)-THF]- in THF are oxidized by dioxygen to afford [(L1re-1)Mn(III)-(O)2-Mn(III)(L1 re-1)]2-as the major product.	Oxygen	54-62	LINE1 retrotransposable element 1	Homo sapiens	103-110
18834155-5	2008	The Pp IX-loaded silica particles have an efficiency of singlet oxygen generation (eta Delta) higher than the quantum yield of free porphyrins.	Oxygen	64-70	endothelin receptor type A	Homo sapiens	83-86
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	44-50	myoglobin	Bos taurus	40-42
18929647-5	2008	The western blot analysis showed that treatment with 1% O2 for 0.5 or 3 h also induced a significant increase in the expression of bystin and that the response of bystin to mild ischemia was much more sensitive than that of GFAP.	Oxygen	56-58	bystin like	Homo sapiens	131-137
18929647-5	2008	The western blot analysis showed that treatment with 1% O2 for 0.5 or 3 h also induced a significant increase in the expression of bystin and that the response of bystin to mild ischemia was much more sensitive than that of GFAP.	Oxygen	56-58	bystin like	Homo sapiens	163-169
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	44-50	myoglobin	Bos taurus	140-142
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	182-188	myoglobin	Bos taurus	29-38
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	182-188	myoglobin	Bos taurus	40-42
25462805-3	2015	However, the temperature dependent shift in Mb oxygen affinity results in a greater oxygen affinity (lower P50) at colder temperatures than occurs at physiological temperature (ca.	Oxygen	47-53	myoglobin	Bos taurus	44-46
19011674-2	2008	Three hours of hypoxia (1% O2) and subsequent reoxygenation for 24 h significantly increased the apoptotic death of hippocampal neurons, as evidenced by increases in both TUNEL-positive cell number and caspase-3 activity.	Oxygen	27-29	caspase 3	Rattus norvegicus	202-211
25462805-3	2015	However, the temperature dependent shift in Mb oxygen affinity results in a greater oxygen affinity (lower P50) at colder temperatures than occurs at physiological temperature (ca.	Oxygen	84-90	myoglobin	Bos taurus	44-46
25462805-7	2015	A TCS Hemox Blood Analyzer was then used to quickly generate an oxygen dissociation curve for the extracted Mb.	Oxygen	64-70	myoglobin	Bos taurus	108-110
25462805-8	2015	The oxygen affinity of extracted bovine Mb was compared to commercially available horse heart Mb.	Oxygen	4-10	myoglobin	Bos taurus	40-42
25480331-6	2015	Lgl1 levels are dramatically reduced in oxygen toxicity rat models of BPD, and heterozygous Lgl1(+/-) mice exhibit features resembling human BPD.	Oxygen	40-46	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	0-4
18806211-0	2008	Oxygen-dependent transcriptional regulator Hap1p limits glucose uptake by repressing the expression of the major glucose transporter gene RAG1 in Kluyveromyces lactis.	Oxygen	0-6	hexose transporter HXT4	Saccharomyces cerevisiae S288C	138-142
19050327-6	2008	Interestingly, in preeclamptic explants, after high oxygen culture, the expression of MMP-2/-9 were recovered to almost same level of those in normal explants.	Oxygen	52-58	matrix metallopeptidase 2	Homo sapiens	86-94
25947054-7	2015	With an increasing ADF% substitution, monitoring identified there to be no subsequent emission effects and that key process parameters contributing to contaminant suppression include (1) precalciner and kiln fuel firing rate and residence time; (2) preheater and precalciner gas and material temperature; (3) rotary kiln flame temperature; (4) fuel-air ratio and percentage of excess oxygen; and (5) the rate of meal feed and rate of clinker produced.	Oxygen	384-390	destrin, actin depolymerizing factor	Homo sapiens	19-23
19050327-7	2008	Treatment of preeclamptic explants with A3 receptor agonist in low oxygen level resulted in an enhanced expression of MMP-2/-9 in a time- and dose-dependent manner.	Oxygen	67-73	matrix metallopeptidase 2	Homo sapiens	118-126
18667416-0	2008	The psbo1 mutant of Arabidopsis cannot efficiently use calcium in support of oxygen evolution by photosystem II.	Oxygen	77-83	PS II oxygen-evolving complex 1	Arabidopsis thaliana	4-9
25673207-0	2015	Time-dependent expression of PEDF and VEGF in blood serum and retina of rats with oxygen-induced retinopathy.	Oxygen	82-88	serpin family F member 1	Rattus norvegicus	29-33
18667416-6	2008	The total flash oxygen yield of the psbo1 mutant was also significantly reduced, as was its stability.	Oxygen	16-22	PS II oxygen-evolving complex 1	Arabidopsis thaliana	36-41
18667416-12	2008	We hypothesize that the PsbO-2 protein cannot effectively sequester calcium at the oxygen-evolving site.	Oxygen	83-89	photosystem II subunit O-2	Arabidopsis thaliana	24-30
20650328-7	2010	RESULTS: Low oxygen tension (5%) was observed to promote extracellular matrix (ECM) production by CCs cultured in the absence of TGF-beta3, but was inhibitory in the presence of TGF-beta3.	Oxygen	13-19	transforming growth factor beta 3	Homo sapiens	178-187
20650328-8	2010	In contrast, a low oxygen tension enhanced chondrogenesis of IFP constructs in the presence of TGF-beta3, leading to superior mechanical functionality compared to CCs cultured in identical conditions.	Oxygen	19-25	transforming growth factor beta 3	Homo sapiens	95-104
25306858-9	2015	Moreover, the translational control of HIF2alpha mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply.	Oxygen	123-129	aconitase 1	Homo sapiens	67-71
20856825-0	2010	COPD and cognitive impairment: the role of hypoxemia and oxygen therapy.	Oxygen	57-63	COPD	Homo sapiens	0-4
20856825-14	2010	Among patients with COPD, hypoxemia is a major contributor and regular use of home oxygen is protective.	Oxygen	83-89	COPD	Homo sapiens	20-24
18927305-0	2008	Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.	Oxygen	22-28	egl-9 family hypoxia inducible factor 2	Homo sapiens	37-42
18927305-2	2008	Our aim was to assess the expression of proteins that act as cellular oxygen sensors, directly regulating the hypoxia inducible factor (HIF) pathway, i.e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET).	Oxygen	70-76	egl-9 family hypoxia inducible factor 2	Homo sapiens	156-198
24934629-14	2015	Postoperative flap TOx was found to correlate with SO2 and was not significantly dependent on blood pressure, supplemental O2, or surgical variables.	Oxygen	52-54	thymocyte selection associated high mobility group box	Homo sapiens	19-22
18710189-5	2008	O2 pressure was observed to decrease the SnO(x) film conductivity.	Oxygen	0-2	strawberry notch homolog 1	Homo sapiens	41-44
18710189-11	2008	These results indicate that CO can produce oxygen vacancies on the SnO(x) surface that ionize and release electrons that increase the SnO(x) film conductivity, as suggested by the oxygen-vacancy model.	Oxygen	43-49	strawberry notch homolog 1	Homo sapiens	67-70
20610613-6	2010	RESULTS: Here, we present a manually curated TCDD-mediated AhR signaling pathway including crosstalks with the hypoxia pathway that copes with oxygen deficiency and the p53 pathway that induces a DNA damage response.	Oxygen	143-149	aryl hydrocarbon receptor	Homo sapiens	59-62
20736373-2	2010	AhR dimerizes with HIF-1beta/AhR, which is shared with HIF-1alpha, a transcription factor critical for the response of cells to oxygen deprivation.	Oxygen	128-134	aryl hydrocarbon receptor	Homo sapiens	0-3
20736373-2	2010	AhR dimerizes with HIF-1beta/AhR, which is shared with HIF-1alpha, a transcription factor critical for the response of cells to oxygen deprivation.	Oxygen	128-134	aryl hydrocarbon receptor	Homo sapiens	29-32
20592263-1	2010	The three Drosophila atypical soluble guanylyl cyclases, Gyc-89Da, Gyc-89Db, and Gyc-88E, have been proposed to act as oxygen detectors mediating behavioral responses to hypoxia.	Oxygen	119-125	Guanylyl cyclase at 88E	Drosophila melanogaster	81-88
18710189-11	2008	These results indicate that CO can produce oxygen vacancies on the SnO(x) surface that ionize and release electrons that increase the SnO(x) film conductivity, as suggested by the oxygen-vacancy model.	Oxygen	43-49	strawberry notch homolog 1	Homo sapiens	134-137
18710189-11	2008	These results indicate that CO can produce oxygen vacancies on the SnO(x) surface that ionize and release electrons that increase the SnO(x) film conductivity, as suggested by the oxygen-vacancy model.	Oxygen	180-186	strawberry notch homolog 1	Homo sapiens	67-70
18710189-11	2008	These results indicate that CO can produce oxygen vacancies on the SnO(x) surface that ionize and release electrons that increase the SnO(x) film conductivity, as suggested by the oxygen-vacancy model.	Oxygen	180-186	strawberry notch homolog 1	Homo sapiens	134-137
18710189-12	2008	The time scale of the response of the SnO(x) films to O2 and CO pressure was also measured by using transient experiments.	Oxygen	54-56	strawberry notch homolog 1	Homo sapiens	38-41
18710189-13	2008	The ultrathin SnO(x) ALD films with a thickness of approximately 10 A were able to respond to O2 within approximately 100 s and to CO within approximately 10 s. These in situ transmission FTIR spectroscopy help confirm the mechanisms for chemiresistant semiconductor gas sensors.	Oxygen	94-96	strawberry notch homolog 1	Homo sapiens	14-17
25159911-4	2015	The example analyzed here is the reaction catalyzed by catechol O-methyltransferase, a methyl transfer reaction from S-adenosylmethionine (SAM) to the nucleophilic oxygen atom of catecholate.	Oxygen	164-170	catechol-O-methyltransferase	Homo sapiens	55-83
18658276-16	2008	MMP-9 plays an important role in the structural changes consequent to oxygen-induced lung injury.	Oxygen	70-76	matrix metallopeptidase 9	Mus musculus	0-5
20435416-8	2010	For instance, COD can be decreased from 7000 mg O(2)/L to 50 mg O(2)/L and 30 mg O(2)/L, using Triton X-114 and Lutensol AO7, respectively at room temperature.	Oxygen	48-52	ring finger protein 25	Homo sapiens	121-124
20435416-8	2010	For instance, COD can be decreased from 7000 mg O(2)/L to 50 mg O(2)/L and 30 mg O(2)/L, using Triton X-114 and Lutensol AO7, respectively at room temperature.	Oxygen	64-68	ring finger protein 25	Homo sapiens	121-124
20435416-8	2010	For instance, COD can be decreased from 7000 mg O(2)/L to 50 mg O(2)/L and 30 mg O(2)/L, using Triton X-114 and Lutensol AO7, respectively at room temperature.	Oxygen	64-68	ring finger protein 25	Homo sapiens	121-124
18551130-5	2008	Oxygen deprivation-induced autophagy did not require nutrient deprivation, hypoxia-inducible factor-1 (HIF-1) activity, or expression of the HIF-1 target gene BNIP3 (Bcl-2 adenovirus E1a nineteen kilodalton interacting protein 3) or BNIP3L (BNIP3 like protein).	Oxygen	0-6	BCL2 interacting protein 3 like	Homo sapiens	233-239
18551130-5	2008	Oxygen deprivation-induced autophagy did not require nutrient deprivation, hypoxia-inducible factor-1 (HIF-1) activity, or expression of the HIF-1 target gene BNIP3 (Bcl-2 adenovirus E1a nineteen kilodalton interacting protein 3) or BNIP3L (BNIP3 like protein).	Oxygen	0-6	BCL2 interacting protein 3 like	Homo sapiens	241-259
25832631-4	2015	Therefore, we hypothesized that GLP-1 secretion is affected by oxygen tension.	Oxygen	63-69	glucagon	Mus musculus	32-37
18956111-9	2008	A similar oxygen dependence was found by Cox et al.	Oxygen	10-16	cytochrome c oxidase subunit 8A	Homo sapiens	41-44
20470447-9	2010	The peak of oxygen uptake correlated with CD34 positive and CD133 positive/CD34 positive cells, r is equal to 0.458 and 0.456; p-value less than 0.05, while no correlations were found between parameters of weight, body composition, and respiratory quotient with progenitor cells.	Oxygen	12-18	prominin 1	Homo sapiens	60-65
20578995-10	2010	Our studies provide the first evidence that disruption of the PKCdelta-dF1Fo interaction using cell-permeant mitochondrial-targeted peptides attenuates cardiac injury resulting from prolonged oxygen deprivation.	Oxygen	192-198	protein kinase C delta	Homo sapiens	62-70
25832631-5	2015	We found that forskolin-stimulated GLP-1 secretion from GLUTag cells, a model of intestinal L cells, is suppressed in hypoxia (1% O2).	Oxygen	130-132	glucagon	Mus musculus	35-40
25832631-11	2015	Our findings suggest that the postprandial decrease in oxygen tension in the intestine attenuates GLP-1 secretion.	Oxygen	55-61	glucagon	Mus musculus	98-103
18926064-10	2008	CONCLUSION: Exposure of AEC II from immature rat to 60% oxygen for 24 hours may produce oxidative injury, inducing apoptosis and decrease in SPC mRNA level of AEC II of premature rat in vitro, while CGRP may play a protective role against hyperoxic lung injury by its antioxidant property, and also inhibition of AEC II apoptosis and promotion of the SPC mRNA expression.	Oxygen	56-62	calcitonin-related polypeptide alpha	Rattus norvegicus	199-203
26273614-7	2015	Additionally, we detected a significant upregulation of the AP-2epsilon mRNA level after oxygen deprivation.	Oxygen	89-95	transcription factor AP-2 epsilon	Homo sapiens	60-71
20581270-1	2010	In this study we identify a cGMP-dependent protein kinase (PKG) cascade as a biochemical pathway critical for controlling low-oxygen tolerance in the adult fruit fly, Drosophila melanogaster.	Oxygen	126-132	Protein kinase, cGMP-dependent at 21D	Drosophila melanogaster	59-62
20581270-9	2010	Therefore, in this report we describe the PKG pathway and the differential protection of function vs survival in a critically low oxygen environment.	Oxygen	130-136	Protein kinase, cGMP-dependent at 21D	Drosophila melanogaster	42-45
18773095-0	2008	Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated [corrected] oxygen-sensing response.	Oxygen	111-117	egl-9 family hypoxia inducible factor 2	Homo sapiens	84-89
26477355-7	2015	A multiple logistic regression analysis revealed that nocturia was associated with oxygen desaturation defined as a 3% decrease (P=0.0335) independent of age (P&lt;0.0001), male sex (P=0.0078), hypertension (P=0.0139), and B-type natriuretic peptide (BNP) level (P=0.0185).	Oxygen	83-89	natriuretic peptide B	Homo sapiens	223-249
18773095-4	2008	Somatic pairing was associated with significant disruption of gene expression within the paired regions and resulted in the deregulation of the prolyl-hydroxylase EGLN2 [corrected] a key protein that regulates the oxygen-dependent degradation of hypoxia-inducible factor (HIF).	Oxygen	214-220	egl-9 family hypoxia inducible factor 2	Homo sapiens	163-168
18773095-8	2008	The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the biology of renal oncocytoma.	Oxygen	145-151	egl-9 family hypoxia inducible factor 2	Homo sapiens	22-27
18729332-5	2008	This is due to partitioning of the benzylic free radial intermediate between oxygen rebound to form 12-OH-NVP and loss of another hydrogen atom to form a reactive quinone methide, which inactivates P450.	Oxygen	77-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	198-202
18565568-5	2008	The following reaction pathway involving two mechanisms was proposed in SO(2) reduction by CO over SnO(2) catalyst: in the first step involving Redox mechanism, the elemental sulfur was produced by the mobility of the lattice oxygen between SO(2) and SnO(2) surface.	Oxygen	226-232	strawberry notch homolog 1	Homo sapiens	99-102
18565568-5	2008	The following reaction pathway involving two mechanisms was proposed in SO(2) reduction by CO over SnO(2) catalyst: in the first step involving Redox mechanism, the elemental sulfur was produced by the mobility of the lattice oxygen between SO(2) and SnO(2) surface.	Oxygen	226-232	strawberry notch homolog 1	Homo sapiens	251-254
18506857-4	2008	The decay rate for luminescence bleaching generally increases with higher laser intensity, however saturating on mica substrates, which is attributed to limited availability of oxygen in the vicinity of the nanotubes.	Oxygen	177-183	MHC class I polypeptide-related sequence A	Homo sapiens	113-117
18547057-1	2008	The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5"-phosphate (PLP) enzyme DOPA decarboxylase (DDC) was here investigated.	Oxygen	12-18	pyridoxal phosphatase	Homo sapiens	77-99
18547057-1	2008	The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5"-phosphate (PLP) enzyme DOPA decarboxylase (DDC) was here investigated.	Oxygen	12-18	pyridoxal phosphatase	Homo sapiens	101-104
18563310-6	2008	Measurement of exercise-induced BNP levels may be a useful alternative to pulmonary artery catheterisation in identifying the patients who are likely to benefit from long-term oxygen therapy.	Oxygen	176-182	natriuretic peptide B	Homo sapiens	32-35
18480242-5	2008	In SAMP1 mice fed catechins and given exercise, oxygen consumption was significantly increased, and there was an increase in skeletal muscle fatty acid beta-oxidation.	Oxygen	48-54	transmembrane protein 201	Mus musculus	3-8
18540637-11	2008	Extended X-ray absorption fine structure (EXAFS) simulations indicate the average Fe-O/N bond length in Dfh is 2.13 A, consistent with a ligand geometry constructed by water and carboxylate oxygens most likely supplied in part by surface-exposed conserved acidic residues located on helix 1 and strand 1 in the structurally characterized frataxin orthologs.	Oxygen	190-197	frataxin	Drosophila melanogaster	104-107
18593917-5	2008	It was found that HIF-1alpha binds hARD1 through the oxygen-dependent degradation domain and, in so doing, dissociates hARD1 from beta-catenin, which prevents beta-catenin acetylation.	Oxygen	53-59	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	35-40
18593917-5	2008	It was found that HIF-1alpha binds hARD1 through the oxygen-dependent degradation domain and, in so doing, dissociates hARD1 from beta-catenin, which prevents beta-catenin acetylation.	Oxygen	53-59	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	119-124
18316119-0	2008	The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation.	Oxygen	12-18	bone morphogenetic protein 2	Homo sapiens	79-84
18316119-4	2008	Strong physisorption was shown to be directly related to the unique properties of NCD, and BMP-2 in its active form interacted strongly when NCD was oxygen-terminated.	Oxygen	149-155	bone morphogenetic protein 2	Homo sapiens	91-96
18780167-4	2008	Conversely, in cancers (particularly the advanced) their mitochondria interact with hexokinase 2 (HK-2) resulting in suppression of cell death while supporting cell growth via enhanced glycolysis, even in the presence of oxygen (Warburg effect).	Oxygen	221-227	hexokinase 2	Homo sapiens	84-96
18364358-2	2008	The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate.	Oxygen	144-152	myo-inositol oxygenase	Homo sapiens	98-102
18416560-1	2008	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Danio rerio	0-11
18416560-1	2008	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Danio rerio	13-16
18356541-1	2008	Hypoxia inducible factor (HIF)-1alpha, a transcription factor, is abundantly expressed in the renal medulla and regulates many oxygen-sensitive genes such as nitric oxide synthase, cyclooxygenase-2, and heme oxygenase-1.	Oxygen	127-133	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	181-197
18071747-3	2008	In this study, we investigated the expression of the rat CA IX in response to chronic hypoxia and to treatment with chemical compounds that disrupt oxygen sensing, including dimethyloxalylglycine, dimethylester succinate, diazoxide, and tempol.	Oxygen	148-154	carbonic anhydrase 9	Homo sapiens	57-62
18071747-7	2008	These data support the view that rats can represent useful model for studies of CA IX as a component of endogenous protection mechanisms associated with hypoxia or perturbed oxygen sensing.	Oxygen	174-180	carbonic anhydrase 9	Homo sapiens	80-85
19099751-9	2008	RESULTS: Exposure to oxygen for 4 d, 7 d, and 14 d resulted in increased mRNA levels of MMP-2 and MMP-9 compared with air-exposed control group (P &lt; 0.01 for all).	Oxygen	21-27	matrix metallopeptidase 2	Rattus norvegicus	88-93
19099751-10	2008	The mean protein levels of active MMP-2 and pro/active MMP-9 after exposure to O2 were higher than air control groups on each experimental day (P &lt; 0.01 or &lt; 0.05).	Oxygen	79-81	matrix metallopeptidase 2	Rattus norvegicus	34-39
19099751-15	2008	CONCLUSION: Hyperoxia exposure elevated the expression of MMP-2 and MMP-9 markedly, which played a role in oxygen-induced lung injury.	Oxygen	107-113	matrix metallopeptidase 2	Rattus norvegicus	58-63
18413745-3	2008	The antioxidant enzyme manganese superoxide dismutase (MnSOD) modulates the cellular redox environment by converting superoxide (O(2)(*-)) to hydrogen peroxide and dioxygen.	Oxygen	164-172	superoxide dismutase 2	Homo sapiens	23-53
18413745-3	2008	The antioxidant enzyme manganese superoxide dismutase (MnSOD) modulates the cellular redox environment by converting superoxide (O(2)(*-)) to hydrogen peroxide and dioxygen.	Oxygen	164-172	superoxide dismutase 2	Homo sapiens	55-60
18076063-8	2008	In contrast, Nox1 shRNA and DPI (NADPH oxidase inhibitor) weakly affect cell spreading while inhibiting O2- production and cell proliferation.	Oxygen	104-106	NADPH oxidase 1	Homo sapiens	13-17
18324815-2	2008	Large permeability of the free-standing nanomembrane to Ru(NH3)63+, O2, or 1,1"-ferrocenedimethanol, which was able to be measured for the first time by employing scanning electrochemical microscopy, is proportional to the density (67 mum-2) and average radius (5.6 nm) of nanopores.	Oxygen	68-70	trafficking protein particle complex subunit 1	Homo sapiens	235-240
18261724-1	2008	The von Hippel-Lindau tumour suppressor protein (pVHL) participates in many cellular processes including oxygen sensing, microtubule stability and primary cilia regulation.	Oxygen	105-111	von Hippel-Lindau tumor suppressor	Homo sapiens	49-53
18364393-2	2008	However, as we show here, Tat apoptosis induction fails in PBMCs cultured at physiological oxygen levels (5% O2).	Oxygen	91-97	tyrosine aminotransferase	Homo sapiens	26-29
18364393-2	2008	However, as we show here, Tat apoptosis induction fails in PBMCs cultured at physiological oxygen levels (5% O2).	Oxygen	109-111	tyrosine aminotransferase	Homo sapiens	26-29
18373847-5	2008	The transcription of HXT2, HXT4 and HXT5 was low when the oxygen concentration in the cultures was low, both under steady state and non-steady state conditions, whereas the expression of HXT6, HXT13 and HXT15/16 was higher in hypoxic than in fully aerobic or anaerobic conditions.	Oxygen	58-64	hexose transporter HXT2	Saccharomyces cerevisiae S288C	21-25
18373847-5	2008	The transcription of HXT2, HXT4 and HXT5 was low when the oxygen concentration in the cultures was low, both under steady state and non-steady state conditions, whereas the expression of HXT6, HXT13 and HXT15/16 was higher in hypoxic than in fully aerobic or anaerobic conditions.	Oxygen	58-64	hexose transporter HXT4	Saccharomyces cerevisiae S288C	27-31
18342297-0	2008	Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.	Oxygen	22-28	nitric oxide synthase 1, neuronal	Mus musculus	101-105
18226911-5	2008	We found that O(2) addition to the (preferentially deprotonated) pyrrole substrate (yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent) is compatible with the observed experimental reaction rate, and that the reaction may then proceed through HO2- elimination, followed by decarboxylation.	Oxygen	14-18	heme oxygenase 2	Homo sapiens	289-292
18335029-4	2008	METHODOLOGY/PRINCIPAL FINDINGS: We illustrate here that NO produced by translocated nNOS (mtNOS) is the insulin-signaling molecule that controls mitochondrial oxygen utilization.	Oxygen	159-165	nitric oxide synthase 1	Homo sapiens	84-88
18184739-1	2008	Renal oxygen consumption (Vo(2,ren)) is an important parameter that has been shown to be influenced by various pathophysiological circumstances.	Oxygen	6-12	renin	Rattus norvegicus	31-34
18184739-2	2008	Vo(2,ren) has to be repeatedly measured during an experiment to gain insight in the dynamics of (dys)regulation of oxygen metabolism.	Oxygen	115-121	renin	Rattus norvegicus	5-8
18199585-7	2008	Diabetes-induced O2(-) accumulation was ablated by the NO synthase (NOS) inhibitor nitro-L-arginine methyl ester (L-NAME), indicating endothelial NOS (eNOS) uncoupling, all of which except heart size were negated by IGF-I.	Oxygen	17-19	nitric oxide synthase 1, neuronal	Mus musculus	55-66
18310146-11	2008	CONCLUSION: Hemoglobin Bonn is a novel hemoglobin variant of the proximal alpha-globin that results in falsely low oxygen saturation measurements with pulse oximetry.	Oxygen	115-121	hemoglobin subunit alpha 2	Homo sapiens	74-86
18350440-5	2008	In mice treated with oxygen, P2Y2 expression was detected in the ganglion and in the nerve fiber layers, whereas P2X2 expression was found in the inner and outer plexiform layers.	Oxygen	21-27	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	113-117
18350440-6	2008	Oxygen-induced preretinal neovascularization was strongly inhibited by the P2 antagonists, suramin (p&lt;0.05) and PPADS (p&lt;0.05), and this was accompanied by a down-regulation of P2X2 receptor expression in the inner plexiform layer in suramin-treated mice.	Oxygen	0-6	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	183-187
17724612-1	2008	PURPOSE: Carbonic anhydrase 9 (CA9) is over-expressed in many human solid tumors under conditions of low oxygen concentration and can be associated with a low probability of survival.	Oxygen	105-111	carbonic anhydrase 9	Homo sapiens	9-29
17724612-1	2008	PURPOSE: Carbonic anhydrase 9 (CA9) is over-expressed in many human solid tumors under conditions of low oxygen concentration and can be associated with a low probability of survival.	Oxygen	105-111	carbonic anhydrase 9	Homo sapiens	31-34
18288196-3	2008	Here we show that the transcriptional coactivator PGC-1alpha (peroxisome-proliferator-activated receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo.	Oxygen	211-217	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	50-60
18288196-3	2008	Here we show that the transcriptional coactivator PGC-1alpha (peroxisome-proliferator-activated receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo.	Oxygen	211-217	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	62-129
18288196-3	2008	Here we show that the transcriptional coactivator PGC-1alpha (peroxisome-proliferator-activated receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo.	Oxygen	211-217	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	223-233
18288196-7	2008	Thus, PGC-1alpha and ERR-alpha, major regulators of mitochondrial function in response to exercise and other stimuli, also control a novel angiogenic pathway that delivers needed oxygen and substrates.	Oxygen	179-185	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	6-16
18205381-3	2008	Studies were then conducted into a unique oxygen transfer reaction between O6-(benzotriazol-1-yl)inosine nucleosides and bis(pinacolato)diboron (pinB-Bpin) leading to the formation of C-6 (benzotriazol-1-yl)purine nucleoside derivatives and pinB-O-Bpin.	Oxygen	42-48	complement C6	Homo sapiens	184-187
18062919-4	2008	In neonatal rat cardiomyocytes and HEK293 cells, SSAT was up-regulated at the transcriptional step primarily by ATP depletion rather than oxygen deprivation.	Oxygen	138-144	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	49-53
18070622-7	2008	The PKCepsilon isoform was activated in both epithelium and whole lens by 5% oxygen when compared to activity at 21% oxygen.	Oxygen	77-83	protein kinase C, epsilon	Mus musculus	4-14
18070622-7	2008	The PKCepsilon isoform was activated in both epithelium and whole lens by 5% oxygen when compared to activity at 21% oxygen.	Oxygen	117-123	protein kinase C, epsilon	Mus musculus	4-14
18070622-8	2008	In hypoxic conditions (5% oxygen) the PKCepsilon co-immunoprecipitated with the mitochondrial cytochrome c oxidase IV subunit (CytCOx).	Oxygen	26-32	protein kinase C, epsilon	Mus musculus	38-48
18070622-17	2008	We hypothesize that elevated oxygen could cause inhibition of PKCepsilon resulting in a loss of mitochondrial protection.	Oxygen	29-35	protein kinase C, epsilon	Mus musculus	62-72
18266131-3	2008	The authors observed significant up-regulation of IL-8 and MCP-1 expression in A549 cells that was independent from the IL-1 receptor pathway but was modified by oxygen tension.	Oxygen	162-168	chemokine (C-X-C motif) ligand 15	Mus musculus	50-54
20616029-7	2010	Activation of AMPK and SIRT1 by FGF21 in adipocytes enhanced mitochondrial oxidative capacity as demonstrated by increases in oxygen consumption, citrate synthase activity, and induction of key metabolic genes.	Oxygen	126-132	fibroblast growth factor 21	Mus musculus	32-37
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	31-41
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	fibroblast growth factor 21	Mus musculus	79-84
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	fibroblast growth factor 21	Mus musculus	144-149
19949909-6	2010	For all of the genes tested (Nrf2, HMOX1, HSPA1A, M1A, ACTC1, and FOS), HBOT elicited large responses, whereas changes were minimal following treatment with 100% O(2) in the absence of elevated pressure.	Oxygen	162-166	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-69
20116442-2	2010	The partial pressures of oxygen at these altitudes are, respectively, about 50% and 30% those at sea level.	Oxygen	25-31	scheggia	Drosophila melanogaster	97-100
20346072-4	2010	The mutation reduces the function of complex I and, like isp-1(qm150), results in low oxygen consumption, slow growth, slow behavior, and increased lifespan.	Oxygen	86-92	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Caenorhabditis elegans	57-62
20633119-2	2010	Rats subjected to four hours of heat stress in a biological oxygen demand incubator at 38 degrees C developed profound hyperthermia (41.23 +/- 0.14 degrees C) and overexpressed HSP 72 kD in several brain regions: cerebral cortex, hippocampus, cerebellum, thalamus, hypothalamus, brain stem, and spinal cord compared to controls.	Oxygen	60-66	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	177-183
20056103-10	2010	Although the oxidative phosphorylation capacity was reduced in atp6-T9176C yeast, the number of ATP molecules synthesized per electron transferred to oxygen was similar compared with wild type yeast.	Oxygen	150-156	F1F0 ATP synthase subunit a	Saccharomyces cerevisiae S288C	63-67
20083575-6	2010	RIP140 exogenous expression in the heart leads to decreased mitochondria state III and state IV membrane potential and oxygen consumption.	Oxygen	119-125	nuclear receptor interacting protein 1	Mus musculus	0-6
20848898-6	2010	CONCLUSION: POP is significantly higher in the deep tissues along the LIM of healthy subjects under normal conditions, which can be downregulated by EA of Hegu (LI 4), suggesting an increase of both the utilization rate of oxygen and energy metabolism after EA.	Oxygen	223-229	lipase family member N	Homo sapiens	161-165
20509977-6	2010	In the present fMRI study we therefore sought to investigate the impact of the COMT val158met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.	Oxygen	120-126	catechol-O-methyltransferase	Homo sapiens	79-83
20307258-3	2010	Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and gave rise to an altered pattern of respiratory supercomplexes.	Oxygen	116-122	cytochrome c oxidase subunit 4I1	Homo sapiens	13-17
20307258-3	2010	Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and gave rise to an altered pattern of respiratory supercomplexes.	Oxygen	116-122	cytochrome c oxidase subunit 5A	Homo sapiens	19-24
20384297-6	2010	The hybrid deposited on the glassy carbon (GC) electrode is demonstrated to be a good bioelectrocatalyst for the reduction of oxygen with inherent enzyme activity, accepted stability, high half-wave potential (ca.670 mV vs NHE), and unimpeded electrical communication to the copper redox sites of laccase.	Oxygen	126-132	solute carrier family 9 member C1	Homo sapiens	223-226
20348304-2	2010	One of the best-studied systems involved in mediating the response to changes in environmental oxygen levels is the Arc two-component system of Escherichia coli, consisting of the sensor kinase ArcB and the cognate response regulator ArcA.	Oxygen	95-101	arginine deiminase	Escherichia coli	234-238
20348304-3	2010	An ArcA ortholog was previously identified in Shewanella, and as in Escherichia coli, Shewanella ArcA is involved in regulating the response to shifts in oxygen levels.	Oxygen	154-160	two-component system response regulator ArcA	Shewanella oneidensis MR-1	3-7
20348304-3	2010	An ArcA ortholog was previously identified in Shewanella, and as in Escherichia coli, Shewanella ArcA is involved in regulating the response to shifts in oxygen levels.	Oxygen	154-160	two-component system response regulator ArcA	Shewanella oneidensis MR-1	97-101
20448661-3	2010	The VHL protein is a component of the oxygen and iron sensing pathway that regulates hypoxia-inducible factor (HIF) levels in the cell.	Oxygen	38-44	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
20385840-0	2010	Bovine cytochrome c oxidase structures enable O2 reduction with minimization of reactive oxygens and provide a proton-pumping gate.	Oxygen	46-48	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	7-27
20385840-1	2010	The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2).	Oxygen	4-8	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	27-47
20385840-1	2010	The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2).	Oxygen	4-8	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	49-52
20374962-4	2010	Islets lacking NeuroD respond poorly to glucose and display a glucose metabolic profile similar to immature beta cells, featuring increased expression of glycolytic genes and LDHA, elevated basal insulin secretion and O2 consumption, and overexpression of NPY.	Oxygen	218-220	neurogenic differentiation 1	Mus musculus	15-21
26477355-7	2015	A multiple logistic regression analysis revealed that nocturia was associated with oxygen desaturation defined as a 3% decrease (P=0.0335) independent of age (P&lt;0.0001), male sex (P=0.0078), hypertension (P=0.0139), and B-type natriuretic peptide (BNP) level (P=0.0185).	Oxygen	83-89	natriuretic peptide B	Homo sapiens	251-254
25613516-5	2015	Furthermore, some neuronal cultures were grown with Glial cell Derived Neurotrophic Factor (GDNF) or basic Fibroblast Growth Factor (bFGF) to tentatively rescue cells from oxygen deprivation.	Oxygen	172-178	fibroblast growth factor 2	Rattus norvegicus	101-131
25613516-5	2015	Furthermore, some neuronal cultures were grown with Glial cell Derived Neurotrophic Factor (GDNF) or basic Fibroblast Growth Factor (bFGF) to tentatively rescue cells from oxygen deprivation.	Oxygen	172-178	fibroblast growth factor 2	Rattus norvegicus	133-137
25552257-7	2015	Interestingly, conditioned media (CCM) from prostate cancer (PCA) cells (LNCaP and PC3) grown under normoxic (~21% O2) and hypoxic (1% O2) conditions significantly enhanced the tube formation in HUVECs, which was compromised in presence of conditioned media from B2G2-treated PCA cells.	Oxygen	115-117	keratin 6A	Homo sapiens	83-86
25552257-7	2015	Interestingly, conditioned media (CCM) from prostate cancer (PCA) cells (LNCaP and PC3) grown under normoxic (~21% O2) and hypoxic (1% O2) conditions significantly enhanced the tube formation in HUVECs, which was compromised in presence of conditioned media from B2G2-treated PCA cells.	Oxygen	135-137	keratin 6A	Homo sapiens	83-86
26728723-3	2015	FZD1, FZD3, SFRP1, and SFRP4 genes were up-regulated after short-term hypoxic stress (0.1% O2), whereas the expression of LEF-1 and RUVBL1 genes was significantly inhibited (down-regulated).	Oxygen	91-93	frizzled class receptor 1	Homo sapiens	0-4
26728723-3	2015	FZD1, FZD3, SFRP1, and SFRP4 genes were up-regulated after short-term hypoxic stress (0.1% O2), whereas the expression of LEF-1 and RUVBL1 genes was significantly inhibited (down-regulated).	Oxygen	91-93	frizzled class receptor 3	Homo sapiens	6-10
26728723-3	2015	FZD1, FZD3, SFRP1, and SFRP4 genes were up-regulated after short-term hypoxic stress (0.1% O2), whereas the expression of LEF-1 and RUVBL1 genes was significantly inhibited (down-regulated).	Oxygen	91-93	secreted frizzled related protein 1	Homo sapiens	12-17
26317897-0	2015	Hyperbaric oxygen therapy palliates lipopolysaccharide-induced acute lung injury in rats by upregulating AQP1 and AQP5 expression.	Oxygen	11-17	aquaporin 1	Rattus norvegicus	105-109
25968948-12	2015	CONCLUSION: Insulin stimulated the expression of miR-210 through the PI3K/Akt pathway, resulting in a protective effect against cardiomyocyte injury that had been induced by H2O2/oxygen species.	Oxygen	179-185	microRNA 210	Rattus norvegicus	49-56
20104488-0	2010	CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1.	Oxygen	58-64	platelet factor 4	Homo sapiens	0-5
25362031-2	2015	Kv1.3, a voltage-gated potassium channel of therapeutic relevance in autoimmunity, is upregulated by activated microglia and mediates amyloid-mediated microglial priming and reactive oxygen species production in vitro.	Oxygen	183-189	potassium voltage-gated channel subfamily A member 3	Homo sapiens	0-5
20187617-1	2010	We report the oxygen K-edge spectra of ices Ih, VI, VII, and VIII measured with X-ray Raman scattering.	Oxygen	14-20	cytochrome c oxidase subunit 8A	Homo sapiens	61-65
24762865-6	2015	Significant improvements were found in cell density, rate of apoptosis, oxidative stress markers, FasL, and caspases in rats treated with hyperbaric oxygen within 72 hours compared to hypoxic-ischemic injury.	Oxygen	149-155	Fas ligand	Rattus norvegicus	98-102
20449353-0	2010	Bidimensional versus tridimensional oxygen vacancy diffusion in SnO(2-x) under different gas environments.	Oxygen	36-42	strawberry notch homolog 1	Homo sapiens	64-67
20449353-3	2010	Experimentally, the electrical resistance of individual metal oxide SnO(2-x) nanowires shows modulation: when the environment is oxygen rich long term drifts (hours) are observed indicating extended vacancy dynamics.	Oxygen	129-135	strawberry notch homolog 1	Homo sapiens	68-71
20449353-6	2010	For oxygen-poor environments, oxygen vacancy excorporation and healing are confined to the near-surface layer of SnO(2-x) (bidimensional or near-surface diffusion), and completed in short times.	Oxygen	4-10	strawberry notch homolog 1	Homo sapiens	113-116
24762865-8	2015	Our findings suggest that hyperbaric oxygen protects against hypoxic-ischemic brain damage by inhibiting oxidative stress and FasL-induced apoptosis, and optimal therapeutic time window is within 72 hours after hypoxic-ischemic brain damage.	Oxygen	37-43	Fas ligand	Rattus norvegicus	126-130
20449353-6	2010	For oxygen-poor environments, oxygen vacancy excorporation and healing are confined to the near-surface layer of SnO(2-x) (bidimensional or near-surface diffusion), and completed in short times.	Oxygen	30-36	strawberry notch homolog 1	Homo sapiens	113-116
26037200-7	2015	Data show that ERRalpha exerts its metabolic control by regulating the expression of SIRT5 that influences oxygen consumption and ATP generation.	Oxygen	107-113	sirtuin 5	Homo sapiens	85-90
20056920-5	2010	METHODS AND RESULTS: Adenoviral-mediated expression of UCP2 caused a mild depression of DeltaPsi(m) and increased the basal rate of oxygen consumption but did not affect total cellular ATP levels.	Oxygen	132-138	uncoupling protein 2	Homo sapiens	55-59
20056920-8	2010	Pretreatment with the UCP2-specific inhibitor genipin largely reversed the effects UCP2 expression on mitochondrial Ca(2+) handling, bioenergetics, and oxygen utilization.	Oxygen	152-158	uncoupling protein 2	Homo sapiens	22-26
25866226-13	2015	Breast cancer cells in vitro showed that HIF-2alpha, CA-9 or CA-12 had an increase expression under hypoxia (1% O2).	Oxygen	112-114	carbonic anhydrase 9	Homo sapiens	53-57
20056920-8	2010	Pretreatment with the UCP2-specific inhibitor genipin largely reversed the effects UCP2 expression on mitochondrial Ca(2+) handling, bioenergetics, and oxygen utilization.	Oxygen	152-158	uncoupling protein 2	Homo sapiens	83-87
20205712-8	2010	Interaction between the O2-sensing hydroxylase PHD1 and HIF-1alpha was demonstrated and revealed exclusive localization of O2-sensing in the nucleus.	Oxygen	24-26	egl-9 family hypoxia inducible factor 2	Homo sapiens	47-51
25866226-13	2015	Breast cancer cells in vitro showed that HIF-2alpha, CA-9 or CA-12 had an increase expression under hypoxia (1% O2).	Oxygen	112-114	carbonic anhydrase 12	Homo sapiens	61-66
20208153-2	2010	In this structure, nitric oxide (NO) is bound to the CcO oxygen-reduction site, which consists of haem and a Cu atom (the haem a(3)-Cu(B) site).	Oxygen	57-63	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	53-56
25498968-4	2015	Electron transfer by the NADPH-P450 oxidoreductase is required for reduction of the heme of P450, necessary for binding of molecular oxygen.	Oxygen	133-139	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	31-35
20032117-7	2010	Exposure of hPTECs to low oxygen tension (1% O2) or the hypoxia mimetic dimethyl-oxalylglycine for 24 h reduced CTGF gene expression in most of the 17 preparations analyzed.	Oxygen	26-32	cellular communication network factor 2	Homo sapiens	112-116
20032117-7	2010	Exposure of hPTECs to low oxygen tension (1% O2) or the hypoxia mimetic dimethyl-oxalylglycine for 24 h reduced CTGF gene expression in most of the 17 preparations analyzed.	Oxygen	45-47	cellular communication network factor 2	Homo sapiens	112-116
25498968-4	2015	Electron transfer by the NADPH-P450 oxidoreductase is required for reduction of the heme of P450, necessary for binding of molecular oxygen.	Oxygen	133-139	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-96
26798519-10	2015	Lowest oxygen saturation (LSAT) M +- SD improved in 146 patients from 83.2 +- 6.8% to 86.2 +- 11.1%, MD 3 oxygen saturation points [95% CI 0.57, 5.63].	Oxygen	7-13	MSD	Homo sapiens	32-39
19769605-13	2010	In conclusion, the present study shows that NHE-1 inhibition facilitates the response to fluid resuscitation after traumatic haemorrhage by improving cardiac function, pulmonary vascular function and oxygen carrying capacity, which results in reduced tissue inflammatory injury.	Oxygen	200-206	sodium/hydrogen exchanger 1	Sus scrofa	44-49
25549101-7	2014	In starvation-stressed TBP/Q36 and TBP/Q79 cells, increased reactive oxygen species generation accelerated the cytoplasmic translocation of HMGB1, which accompanied autophagy activation.	Oxygen	69-75	high mobility group box 1	Homo sapiens	140-145
20097158-5	2010	Our study suggests that curcumin and masoprocol can serve as lead-candidate prophylactics for reactive oxygen species induced chaperone damage, protein misfolding and neurodegenerative disease; importantly, they can play a vital role in sustaining traffic along the ER"s secretory pathway by preserving functional integrity of PDI.	Oxygen	103-109	prolyl 4-hydroxylase subunit beta	Homo sapiens	327-330
20715898-7	2010	However, following hyperbaric oxygen (HBO) treatment in VD rats, rCBF increased, rCBV decreased and MTT increased.	Oxygen	30-36	CCAAT/enhancer binding protein zeta	Rattus norvegicus	65-69
19298519-10	2010	We have identified PEDF in healthy and ischemic human hearts and we show that PEDF expression is down-regulated by low oxygen levels.	Oxygen	119-125	serpin family F member 1	Homo sapiens	78-82
20062524-3	2010	We also show that the phagocytosis of yeast and the release of reactive oxygen intermediates in response to Candida albicans challenge are impaired in macrophages from Dectin-1 deficient mice treated with PPARgamma ligands or IL-13.	Oxygen	72-78	peroxisome proliferator activated receptor gamma	Mus musculus	205-214
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	CD28 molecule	Homo sapiens	231-235
19549068-7	2009	Apart from changes in glycolytic flux, the role of both the cytochrome-c oxidase (COX) and the alternative oxidase (AOX) in the adaptive response of respiration to changes in the oxygen availability are discussed.	Oxygen	179-185	cytochrome c oxidase subunit 8A	Homo sapiens	60-80
19549068-7	2009	Apart from changes in glycolytic flux, the role of both the cytochrome-c oxidase (COX) and the alternative oxidase (AOX) in the adaptive response of respiration to changes in the oxygen availability are discussed.	Oxygen	179-185	cytochrome c oxidase subunit 8A	Homo sapiens	82-85
19812042-9	2009	Importantly, this structural rearrangement positioned one of the oxygen atoms of Asp(52) within 4.3 A of the gamma-phosphate of ATP bound to Srx.	Oxygen	65-71	sulfiredoxin 1	Homo sapiens	141-144
19956414-12	2009	MiR-29b increased cell viability under both chronic oxidative stress and physiologic oxygen concentrations.	Oxygen	85-91	microRNA 29b-1	Homo sapiens	0-7
17845820-3	2008	However, the oxygen affinity of the reconstituted myoglobin is lower than that of the myoglobin having an iron porphycene without trifluoromethyl groups, which is mainly originated from the enhancement of the O(2) dissociation.	Oxygen	13-19	myoglobin	Physeter catodon	50-59
18290322-5	2008	Hypoxia-inducible factor (HIF)-1alpha, the master transcriptional regulator of the hypoxic response, as well as certain downstream genes, e.g., glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX, have been considered to be suitable as surrogate biomarkers of hypoxia due to their tight regulation by O2 levels under certain, well-defined in vitro conditions.	Oxygen	309-311	carbonic anhydrase 9	Homo sapiens	177-203
18156205-5	2008	Moreover, addition of TGF-beta 3 to villous explants under low oxygen conditions increased the expression of endoglin compared to nontreated explants whereas addition of TGF-beta 3-neutralizing antibodies inhibited the low oxygen stimulatory effect on endoglin expression.	Oxygen	63-69	transforming growth factor beta 3	Homo sapiens	22-32
18156205-5	2008	Moreover, addition of TGF-beta 3 to villous explants under low oxygen conditions increased the expression of endoglin compared to nontreated explants whereas addition of TGF-beta 3-neutralizing antibodies inhibited the low oxygen stimulatory effect on endoglin expression.	Oxygen	223-229	transforming growth factor beta 3	Homo sapiens	170-180
18156205-7	2008	These data demonstrate that oxygen regulates the placental expression of endoglin via TGF-beta 3.	Oxygen	28-34	transforming growth factor beta 3	Homo sapiens	86-96
18785680-7	2008	A DFT analysis of the oxygenation reaction mediated by the micro-eta2:eta2 peroxo core demonstrates that the major barrier after O2 binding corresponds to electrophilic attack on the arene ring.	Oxygen	129-131	DNA polymerase iota	Homo sapiens	65-69
18785680-7	2008	A DFT analysis of the oxygenation reaction mediated by the micro-eta2:eta2 peroxo core demonstrates that the major barrier after O2 binding corresponds to electrophilic attack on the arene ring.	Oxygen	129-131	DNA polymerase iota	Homo sapiens	70-74
19213326-9	2008	We also predicted a decrease of the Tafel slope from 70 to 65 mV dec(-1) at 80 degrees C with increasing oxygen partial pressure, which is consistent with the observation reported in literature.	Oxygen	105-111	deleted in esophageal cancer 1	Homo sapiens	65-71
17999505-8	2007	This reduction potential corresponds to an overpotential for the reaction of the charge carriers with O2 of approximately 0.6 V. N,N"-1H,1H-Perfluorobutyl derivatives of the perylene-based semiconductors were also synthesized and used to fabricate OFETs, resulting in air-stable devices for all fluorocarbon-substituted materials, despite generally having E(red1) &lt; -0.1 V. This behavior is consistent with a fluorocarbon-based O2 barrier mechanism.	Oxygen	102-104	adenosine deaminase RNA specific B1	Homo sapiens	358-362
17941623-4	2007	In this paper, we have further examined the inhibitory properties of ethane-1,2-diones toward these proteins and determined that, when the carbonyl oxygen atoms are cis-coplanar, the compounds demonstrate specificity for hCE1.	Oxygen	148-154	carboxylesterase 1	Homo sapiens	221-225
17658597-9	2007	Following 3 days exposure to low oxygen there was reduced EPC outgrowth, reduced Igf2 and increased Tpbp mRNA levels, suggesting commitment to the spongiotrophoblast lineage.	Oxygen	33-39	trophoblast specific protein alpha	Mus musculus	100-104
17921881-0	2007	Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy.	Oxygen	115-121	Wnt family member 3	Rattus norvegicus	51-56
17921881-3	2007	We examined whether hyperbaric oxygen promoted neural stem cells to proliferate and its correlation with Wnt-3 protein in hypoxic-ischemic neonate rats.	Oxygen	31-37	Wnt family member 3	Rattus norvegicus	105-110
17921881-9	2007	We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein.	Oxygen	27-33	Wnt family member 3	Rattus norvegicus	104-109
17826792-5	2007	The aromatic ring of CAP-1 inserts into the cavity, with the urea NH groups forming hydrogen bonds with the backbone oxygen of Val59 and the dimethylamonium group interacting with the side-chains of Glu28 and Glu29.	Oxygen	117-123	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	21-26
17895552-1	2007	BACKGROUND: Because the arterial/alveolar oxygen tension ratio (a/APO2) is relatively constant throughout the entire range of fractional inspired oxygen concentration (FiO2), its use in determining the prognosis of acute pulmonary embolism (APE) was investigated.	Oxygen	42-48	TNF receptor superfamily member 10a	Homo sapiens	66-70
17895552-1	2007	BACKGROUND: Because the arterial/alveolar oxygen tension ratio (a/APO2) is relatively constant throughout the entire range of fractional inspired oxygen concentration (FiO2), its use in determining the prognosis of acute pulmonary embolism (APE) was investigated.	Oxygen	146-152	TNF receptor superfamily member 10a	Homo sapiens	66-70
17182138-7	2007	Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r=0.6, p=0.009) and pulmonary regurgitant fraction (r=0.54, p=0.026), and negatively with exercise duration (r=-0.45, p=0.021), peak oxygen consumption (r=-0.43, p=0.03), and minute ventilation at maximal exercise (r=-0.52, p=0.006).	Oxygen	211-217	natriuretic peptide B	Homo sapiens	7-10
17182138-8	2007	Multivariate analysis demonstrated BNP levels (beta=-0.43, p=0.034) and body mass index (beta=-0.40, p=0.036) to be independent predictors of peak oxygen consumption.	Oxygen	147-153	natriuretic peptide B	Homo sapiens	35-38
17898307-0	2007	Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy.	Oxygen	79-85	aquaporin 1	Mus musculus	0-11
17898307-10	2007	CONCLUSIONS: Microvessel proliferation in oxygen-induced retinopathy is AQP1-independent.	Oxygen	42-48	aquaporin 1	Mus musculus	72-76
17620457-2	2007	Among the P2X receptors that TNP-ATP specifically blocks, mainly P2X1 seems to be involved in the processes of cell damage after oxygen/glucose deprivation.	Oxygen	129-135	purinergic receptor P2X 1	Rattus norvegicus	65-69
17713902-4	2007	The reaction of [(BIT(OH,SMe))Cu(CH3CN)]PF6 (2a) with dioxygen produces [(BIT(O,SOMe))2Cu2(DMF)2](PF6)2 (4), whose X-ray structure revealed the presence of bridging BIT-alkoxo ligands and terminal -SOMe groups.	Oxygen	54-62	sperm associated antigen 17	Homo sapiens	40-43
17713902-4	2007	The reaction of [(BIT(OH,SMe))Cu(CH3CN)]PF6 (2a) with dioxygen produces [(BIT(O,SOMe))2Cu2(DMF)2](PF6)2 (4), whose X-ray structure revealed the presence of bridging BIT-alkoxo ligands and terminal -SOMe groups.	Oxygen	54-62	sperm associated antigen 17	Homo sapiens	98-101
17545484-12	2007	Inhibition of VEGFR2 signaling in explants maintained under hypoxic (2% O(2)) conditions completely abolished vascularization and slightly decreased epithelial branching.	Oxygen	72-77	kinase insert domain protein receptor	Mus musculus	14-20
17910795-0	2007	Accurate myoglobin oxygen saturation by optical spectroscopy measured in blood-perfused rat muscle.	Oxygen	19-25	myoglobin	Rattus norvegicus	9-18
17910795-10	2007	Myoglobin saturation was significantly increased when the fraction of inspired O(2) was increased, showing that manipulations of myoglobin saturation are detectable and that myoglobin is not fully saturated in resting muscle.	Oxygen	79-83	myoglobin	Rattus norvegicus	0-9
17910795-10	2007	Myoglobin saturation was significantly increased when the fraction of inspired O(2) was increased, showing that manipulations of myoglobin saturation are detectable and that myoglobin is not fully saturated in resting muscle.	Oxygen	79-83	myoglobin	Rattus norvegicus	129-138
18457016-0	2007	Neuroprotective effect of ultra-low doses of antibodies against S100 protein in neuroblastoma culture during oxygen and glucose deprivation.	Oxygen	109-115	S100 calcium binding protein A1	Mus musculus	64-68
18457016-1	2007	Antibodies against S100 protein applied in high and ultra-high dilutions possess neuroprotective activity and maintain survival of neuroblastoma C-1300 cells under conditions of oxygen and glucose deprivation.	Oxygen	178-184	S100 calcium binding protein A1	Mus musculus	19-23
17576755-2	2007	Subsequently, we demonstrated that expression of the hbp family is significantly influenced by oxygen, heme, and temperature conditions encountered by the pathogen in the human host and the body louse vector; e.g., we observed a dramatic (&gt;100-fold) increase in hbpC transcript levels in response to the "louse-like" temperature of 30 degrees C. The goal of the present study was to identify a transcription factor(s) involved in the coordinated and differential regulation of the hbp family.	Oxygen	95-101	heme binding protein 1	Homo sapiens	53-56
17521773-3	2007	Stimulatory effects of PACAP and VIP on cyclic AMP formation were significantly smaller in cell cultures subjected to 24h lasting hypoxic conditions, induced either chemically (100 microM cobalt chloride) or by low 3% oxygen hypoxia, compared to the normoxic condition (95% air and 5% CO(2)).	Oxygen	218-224	adenylate cyclase activating polypeptide 1	Rattus norvegicus	23-28
17610843-2	2007	Here, we show that HIF-1alpha undergoes post-translational modification by the three isoforms of the small ubiquitin-related modifier (SUMO-1, -2 and -3) in vitro in proximity to and within the oxygen-dependent degradation domain (ODDD).	Oxygen	194-200	small ubiquitin like modifier 1	Homo sapiens	135-152
17893650-12	2007	We conclude that ARBP and HPRT exhibit expression that is sufficiently stable under conditions of varying oxygen tension, to permit their use as housekeeping genes in at least one model of OIR in the neonatal rat.	Oxygen	106-112	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	26-30
17595166-0	2007	4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.	Oxygen	61-67	SREBF chaperone	Homo sapiens	46-50
17595166-1	2007	In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply.	Oxygen	87-93	SREBF chaperone	Homo sapiens	51-55
17595166-1	2007	In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply.	Oxygen	87-93	synaptonemal complex protein 1	Homo sapiens	73-77
17595166-1	2007	In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply.	Oxygen	146-152	SREBF chaperone	Homo sapiens	51-55
17595166-1	2007	In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply.	Oxygen	146-152	synaptonemal complex protein 1	Homo sapiens	73-77
17652159-7	2007	Some motor, centrosome and kinetochore proteins (dynein, Kin-8, Cnn, TACC, Cenp-C, Nuf2) are rapidly relocalized after oxygen deprivation.	Oxygen	119-125	Kinesin-like protein at 67A	Drosophila melanogaster	57-62
25104852-10	2014	Taken together, the results support the hypothesis that reduced expression of frataxin leads to elevation of COX2-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species.	Oxygen	226-232	cytochrome c oxidase II, mitochondrial	Mus musculus	109-113
17630686-2	2007	This simulation suggests that the observed band at 1016 cm(-1) is attributed to the Mo=O-Mg stretching from two-coordinate oxygen atoms that are adjacent to Mg2+ cation vacancies.	Oxygen	123-129	mucin 7, secreted	Homo sapiens	157-160
17437535-0	2007	Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway.	Oxygen	30-36	G protein-coupled receptor kinase 2	Rattus norvegicus	19-23
17437535-3	2007	In this study, we investigated the molecular mechanisms involved in GRK2 down-regulation, using organotypic cultures of neonatal rat hippocampal slices exposed to oxygen and glucose deprivation (OGD).	Oxygen	163-169	G protein-coupled receptor kinase 2	Rattus norvegicus	68-72
25696908-10	2014	Therefore, further studies are warranted to elucidate to what extent differences in oxygen tensions in these diverse microenvironments influence HSPC homeostasis.	Oxygen	84-90	proteasome 20S subunit alpha 7	Homo sapiens	145-149
17696611-0	2007	SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast.	Oxygen	15-21	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-5
17696611-5	2007	Sre1, the yeast ortholog of the mammalian membrane-bound transcription factor sterol regulatory element binding protein (SREBP), directly induces the expression and mobilization of Tf2 retrotransposons under low oxygen.	Oxygen	212-218	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	78-119
17696611-5	2007	Sre1, the yeast ortholog of the mammalian membrane-bound transcription factor sterol regulatory element binding protein (SREBP), directly induces the expression and mobilization of Tf2 retrotransposons under low oxygen.	Oxygen	212-218	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	121-126
25216582-9	2014	Cells grew further to 6.30 g/l CDW containing 91 % PHB when oxygen-responsive transcription factor ArcA (arcA) was deleted in the same recombinant E. coli S17-1.	Oxygen	60-66	arginine deiminase	Escherichia coli	99-103
17441787-3	2007	NO also binds to the binuclear centre of COX (cytochrome c oxidase) and inhibits mitochondrial respiration in competition with oxygen and in a reversible manner.	Oxygen	127-133	cytochrome c oxidase subunit 8A	Homo sapiens	41-44
25216582-9	2014	Cells grew further to 6.30 g/l CDW containing 91 % PHB when oxygen-responsive transcription factor ArcA (arcA) was deleted in the same recombinant E. coli S17-1.	Oxygen	60-66	arginine deiminase	Escherichia coli	105-109
25064222-0	2014	Effects of high-pressure oxygen therapy on brain tissue water content and AQP4 expression in rabbits with cerebral hemorrhage.	Oxygen	25-31	aquaporin-4	Oryctolagus cuniculus	74-78
17005382-6	2007	The fluorescence emission of Ru(dpp)(3) can be dynamically quenched by oxygen.	Oxygen	71-77	dipeptidyl peptidase 3	Homo sapiens	29-38
17005382-9	2007	Human bone marrow stromal cells HS-5 were successfully cultured on the oxygen sensing scaffold, and the observed Ru(dpp)(3) emission intensity from the scaffold was stronger in cell rich area, which indicates a lower oxygen level due to the consumption of the cells.	Oxygen	71-77	dipeptidyl peptidase 3	Homo sapiens	113-122
17005382-9	2007	Human bone marrow stromal cells HS-5 were successfully cultured on the oxygen sensing scaffold, and the observed Ru(dpp)(3) emission intensity from the scaffold was stronger in cell rich area, which indicates a lower oxygen level due to the consumption of the cells.	Oxygen	217-223	dipeptidyl peptidase 3	Homo sapiens	113-122
17519806-6	2007	Expressions of IL-1beta, IL-12p40, TLR-2, and TLR-4 were increased in cortex/subcortex after resuscitation with 100% O2 compared with 21% O2 (all p &lt; 0.05) and to controls (all p &lt; 0.05).	Oxygen	117-119	toll-like receptor 2	Ovis aries	35-40
19718046-3	2009	In this study, we show that hypoxia (1% oxygen) promotes the self-renewal capacity of CD133-positive human glioma-derived cancer stem cells (CSCs).	Oxygen	40-46	prominin 1	Homo sapiens	86-91
19938161-9	2009	ASC-transplanted R6/2 mice expressed elevated levels of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and reactive oxygen defense enzymes and showed activation of the Akt/cAMP-response element-binding proteins.	Oxygen	150-156	steroid sulfatase	Mus musculus	0-3
19796941-1	2009	Piperazinyl-glutamate-pyrimidines were prepared with oxygen, nitrogen, and sulfur substitution at the 4-position of the pyrimidine leading to highly potent P2Y12 antagonists.	Oxygen	53-59	purinergic receptor P2Y12	Homo sapiens	156-161
19756382-4	2009	The major role of prolyl and asparaginyl hydroxylation in regulating HIFs is described, as well as the identification of PHD1-3 and FIH as the oxygen-sensing enzymes responsible for these hydroxylations.	Oxygen	143-149	egl-9 family hypoxia inducible factor 2	Homo sapiens	121-127
18050914-7	2007	The storage stability of the co-immobilized GOD-CAT was also found to be higher than that of the free form at both 5 degrees C and 25 degrees C. The increased GOD activity and reusability resulting from the co-immobilization process may have been due to CAT protecting GOD from inactivation by H2O2 and supplying additional O2 to the reaction system.	Oxygen	296-298	catalase	Bos taurus	254-257
25394287-6	2014	Traces of water and dioxygen in solutions of (iPr2)6/(iPr2)7 yield the di(mu-oxido) complex [Mo(V)((iPr2)L)O]2(mu-O)2 ((iPr2)4) with reduced steric congestion due to dissociation of the bulky chelate ligands.	Oxygen	20-28	adaptor related protein complex 1 subunit mu 2	Homo sapiens	111-117
17498241-0	2007	Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current.	Oxygen	74-80	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
19720742-2	2009	HIF alpha undergoes oxygen-dependent prolyl hydroxylation, which marks it for polyubiquitination by a complex containing the von Hippel-Lindau protein (pVHL).	Oxygen	20-26	von Hippel-Lindau tumor suppressor	Homo sapiens	152-156
17498241-0	2007	Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current.	Oxygen	74-80	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
24975631-8	2014	Different GFs, such as NGF, bFGF, and GDNF, and their combination were used to rescue cells from serum and/or oxygen deprivation.	Oxygen	110-116	glial cell line derived neurotrophic factor	Mus musculus	38-42
17498241-2	2007	Here we found that PACAP-38 elevated cytosolic [Ca(2+)] ([Ca(2+)](i)) in the oxygen sensing type I cells but not the glial-like type II (sustentacular) cells of the rat carotid body.	Oxygen	77-83	adenylate cyclase activating polypeptide 1	Rattus norvegicus	19-24
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	49-55	Fms related receptor tyrosine kinase 1	Rattus norvegicus	147-153
25293376-9	2014	Low oxygen supply upregulated CXCR4, CCR7 and CXCR6, but downregulated CXCL12 and CCR1.	Oxygen	4-10	C-X-C motif chemokine ligand 12	Homo sapiens	71-77
18767059-1	2009	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Oxygen	182-188	fibroblast growth factor 2	Rattus norvegicus	106-132
18767059-1	2009	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Oxygen	182-188	fibroblast growth factor 2	Rattus norvegicus	134-139
18767059-1	2009	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Oxygen	190-192	fibroblast growth factor 2	Rattus norvegicus	106-132
18767059-1	2009	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Oxygen	190-192	fibroblast growth factor 2	Rattus norvegicus	134-139
17582265-0	2007	[Changes of Wnt-3 protein during the proliferation of endogenous neural stem cells in neonatal rats with hypoxic-ischemic brain damage after hyperbaric oxygen therapy].	Oxygen	152-158	Wnt family member 3	Rattus norvegicus	12-17
18767059-9	2009	These findings suggest that oxygen plasma modification can immobilize FGF-2 onto a titanium surface.	Oxygen	28-34	fibroblast growth factor 2	Rattus norvegicus	70-75
25293376-9	2014	Low oxygen supply upregulated CXCR4, CCR7 and CXCR6, but downregulated CXCL12 and CCR1.	Oxygen	4-10	C-C motif chemokine receptor 1	Homo sapiens	82-86
25341076-7	2014	In the case of in situ charged bulk crystalline Li2O2, the Li vacancies preferentially form on the interlayer position (Li1), which is supported by first-principle calculations and consistent with their lower energy compared to those located next to oxygen (Li2).	Oxygen	250-256	ATP binding cassette subfamily A member 12	Homo sapiens	48-51
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase like 4	Homo sapiens	40-45
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase like 4	Homo sapiens	296-301
17455918-11	2007	It was revealed that the HO2 formation mechanism changes at 500 K, i.e., HCO + O2 via HCHO + OH and the above proposed direct HCO formation dominates over 500 K, while a series of reactions following CH3OCH2O2 self-reaction and OH + CH3OCH2O2 reaction mainly contribute below 500 K. The pressure dependent rate constant of the CH3OCH2 thermal decomposition reaction has been separately measured since it has large negative sensitivity for HO2 formation and is essential to eliminate the ambiguity in the CH3OCH2 + O2 mechanism at higher temperature.	Oxygen	26-28	heme oxygenase 2	Homo sapiens	439-442
17470809-0	2007	A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase.	Oxygen	53-61	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	94-114
17470809-1	2007	Cytochrome c oxidase transfers electrons and protons for dioxygen reduction coupled with proton pumping.	Oxygen	57-65	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
17470809-3	2007	Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) of bovine heart cytochrome c oxidase.	Oxygen	114-122	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	166-186
19650765-1	2009	Mb (myoglobin) is a haemoprotein present in cardiac, skeletal and smooth muscle and is primarily responsible for the storage and "facilitated transfer" of molecular oxygen from the cell membrane to mitochondria.	Oxygen	165-171	myoglobin	Rattus norvegicus	0-2
19650765-1	2009	Mb (myoglobin) is a haemoprotein present in cardiac, skeletal and smooth muscle and is primarily responsible for the storage and "facilitated transfer" of molecular oxygen from the cell membrane to mitochondria.	Oxygen	165-171	myoglobin	Rattus norvegicus	4-13
17456219-6	2007	RESULTS: NAC (0.1-1 mm) inhibited the extracellular generation of oxygen species induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and eotaxin (in the presence of IL-5) with -logIC(50) values of 3.61+/-0.03 and 3.36+/-0.09, respectively.	Oxygen	66-72	interleukin 5	Homo sapiens	177-181
25406276-0	2014	Pulmonary surfactant protein a is expressed in mouse retina by Muller cells and impacts neovascularization in oxygen-induced retinopathy.	Oxygen	110-116	surfactant associated protein A1	Mus musculus	10-30
17522445-2	2007	NO is synthesized from L-arginine and oxygen by nitric oxide synthase: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS).	Oxygen	38-44	nitric oxide synthase 1	Homo sapiens	81-85
25406276-5	2014	Retinal SP-A was then measured in the oxygen-induced retinopathy (OIR) mouse model.	Oxygen	38-44	surfactant associated protein A1	Mus musculus	8-12
25450395-0	2014	Silibinin activates AMP-activated protein kinase to protect neuronal cells from oxygen and glucose deprivation-re-oxygenation.	Oxygen	80-86	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-48
17293559-2	2007	We show that pharmacological activation of A(1) adenosine and mGlu3 metabotropic glutamate receptors with N(6)-chlorocyclopentyladenosine (CCPA) and (-)2-oxa-4-aminocyclo-[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), respectively, protects cultured astrocytes against apoptosis induced by a 3-h exposure to oxygen/glucose deprivation (OGD).	Oxygen	309-315	glutamate receptor, metabotropic 3	Mus musculus	62-67
25320837-3	2014	In the atmosphere, R2 and R4 react with O2 by irreversible H-abstraction to dimethylphenols or by reversible additions to bicyclic radical intermediates, which would recombine again with O2 to form bicyclic peroxy radicals, to bicyclic alkoxyl radicals by reacting with NO or HO2, and eventually to final products such as glyoxal, methylglyoxal, and their coproducts.	Oxygen	40-42	heme oxygenase 2	Homo sapiens	276-279
25368913-5	2014	Furthermore, the siRNA was released from the FRS-NPs in the cells and knocked down ICAM-1 expression in the TNF-alpha-stimulated cells and in the cells under oxygen-glucose deprivation/reoxygenation (OGD/R) condition.	Oxygen	158-164	intercellular adhesion molecule 1	Mus musculus	83-89
17303578-4	2007	Rather, under both 20 and 80% O(2), mitochondrial reactive oxygen species (ROS) production is approximately 2-fold less in HeLa-80 cells, likely related to a significantly higher cytochrome c oxidase (COX) activity ( approximately 2-fold), which may act to deplete upstream electron-rich intermediates responsible for ROS generation.	Oxygen	30-34	cytochrome c oxidase subunit 8A	Homo sapiens	201-204
25064694-6	2014	Decrease in fractional oxygen concentration of just 0.9% was associated with phosphorylation of ERK1/2, but not Akt, which was essential for up-regulation of SUR2A.	Oxygen	23-29	mitogen-activated protein kinase 3	Mus musculus	96-102
17307737-7	2007	To gain further insight into the responses of the regulatory networks, the activities of key transcription factors during the transition to micro-aerobic conditions were inferred using a probabilistic modeling approach, which revealed that the response of the direct oxygen sensor FNR was rapid and overshot, whereas the indirect oxygen sensor ArcA reacted more slowly.	Oxygen	267-273	arginine deiminase	Escherichia coli	344-348
17307737-7	2007	To gain further insight into the responses of the regulatory networks, the activities of key transcription factors during the transition to micro-aerobic conditions were inferred using a probabilistic modeling approach, which revealed that the response of the direct oxygen sensor FNR was rapid and overshot, whereas the indirect oxygen sensor ArcA reacted more slowly.	Oxygen	330-336	arginine deiminase	Escherichia coli	344-348
24521195-1	2014	OBJECTIVES: This study aimed to compare the levels of plasma B-type natriuretic peptide (BNP) and C-reactive protein (CRP) in relation to oxygen transport between patients with restrictive right ventricle (rRV) and those without (non-rRV) early after tetralogy of Fallot (TOF) repair.	Oxygen	138-144	natriuretic peptide B	Homo sapiens	61-87
17371021-6	2007	When the Schiff base nitrogen atoms of the adducts carry an aliphatic substituent such as in the internal and external aldimines of PLP in the enzymatic environment, protonation of the ring nitrogen shifts the proton in the intramolecular OHN hydrogen bond from the oxygen to the Schiff base nitrogen.	Oxygen	266-272	pyridoxal phosphatase	Homo sapiens	132-135
24521195-1	2014	OBJECTIVES: This study aimed to compare the levels of plasma B-type natriuretic peptide (BNP) and C-reactive protein (CRP) in relation to oxygen transport between patients with restrictive right ventricle (rRV) and those without (non-rRV) early after tetralogy of Fallot (TOF) repair.	Oxygen	138-144	natriuretic peptide B	Homo sapiens	89-92
25128603-2	2014	TSC improves the diffusion of oxygen and glucose, and increases oxygenation in ischemic brain tissue.	Oxygen	30-36	solute carrier family 12 member 3	Rattus norvegicus	0-3
17218454-0	2007	Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture.	Oxygen	106-112	myoglobin	Rattus norvegicus	41-50
17218454-4	2007	Based on the DMb, the equipoise diffusion PO2, the PO2 in which Mb-facilitated and free O2 diffusion contribute equally to the O2 flux, varies from 2.72 to 0.15 in myocardium and from 7.27 to 4.24 mmHg in skeletal muscle.	Oxygen	43-45	myoglobin	Rattus norvegicus	14-16
17218454-7	2007	In marine mammals, the high Mb concentration confers a predominant role for Mb in intracellular O2 transport under all physiological conditions.	Oxygen	96-98	myoglobin	Rattus norvegicus	28-30
17218454-7	2007	In marine mammals, the high Mb concentration confers a predominant role for Mb in intracellular O2 transport under all physiological conditions.	Oxygen	96-98	myoglobin	Rattus norvegicus	76-78
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	aminopeptidase O	Sus scrofa	37-43
17426211-0	2007	Effects of a walking aid in COPD patients receiving oxygen therapy.	Oxygen	52-58	activation induced cytidine deaminase	Homo sapiens	21-24
17426211-1	2007	STUDY OBJECTIVES: To elucidate whether a simple walking aid may improve physical performance in COPD patients with chronic respiratory insufficiency who usually carry their own heavy oxygen canister.	Oxygen	183-189	activation induced cytidine deaminase	Homo sapiens	56-59
17426211-8	2007	CONCLUSIONS: This study suggests that a simple walking aid may be helpful in COPD patients receiving long-term oxygen therapy, particularly in those with lower residual exercise capacity.	Oxygen	111-117	activation induced cytidine deaminase	Homo sapiens	55-58
17454123-1	2007	Serotonin, an important neurotransmitter, is colocalized with neuronal nitric oxide synthase (nNOS), a homodimeric enzyme which catalyzes the production of nitric oxide (NO(.-)) and/or oxygen species.	Oxygen	185-191	nitric oxide synthase 1	Homo sapiens	62-92
17454123-1	2007	Serotonin, an important neurotransmitter, is colocalized with neuronal nitric oxide synthase (nNOS), a homodimeric enzyme which catalyzes the production of nitric oxide (NO(.-)) and/or oxygen species.	Oxygen	185-191	nitric oxide synthase 1	Homo sapiens	94-98
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	glutamate ionotropic receptor delta type subunit 1	Sus scrofa	53-58
17454194-4	2007	To date the most common identified cause of IE has been mutations in the von Hippel Landau (VHL) protein, which results in aberrant oxygen sensing and dysregulated Epo production.	Oxygen	132-138	von Hippel-Lindau tumor suppressor	Homo sapiens	92-95
24273102-0	2014	Cyclooxygenase-2 inhibition partially protects against 60% O2 -mediated lung injury in neonatal rats.	Oxygen	59-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-16
24712343-7	2014	A low oxygen tension reduced lubricin gene expression levels in bovine superficial chondrocytes, TGF-beta1-treated middle/deep zone chondrocytes, and TGF-beta1-treated ATDC5 cells.	Oxygen	6-12	transforming growth factor beta 1	Bos taurus	150-159
17419396-3	2007	Patients with COPD exacerbations are recommended to be treated with additional inhalations of beta-2 agonists and anti -cholinergic agents, systemic administered glucocorticosteroids, oxygen inhalation, and, in cases with purulent sputum, antibiotics.	Oxygen	184-190	COPD	Homo sapiens	14-18
25162936-12	2014	The analysis shows that the intermolecular hydrogen bonding between active site residues and the phenolic oxygen of PLP shifts the tautomeric equilibrium toward the N-protonated ketoenamine tautomeric form.	Oxygen	106-112	pyridoxal phosphatase	Homo sapiens	116-119
17322643-0	2007	Hyperbaric oxygen induces basic fibroblast growth factor and hepatocyte growth factor expression, and enhances blood perfusion and muscle regeneration in mouse ischemic hind limbs.	Oxygen	11-17	fibroblast growth factor 2	Mus musculus	26-56
19738050-10	2009	Our findings provide a novel insight into the regulatory mechanisms of CD133 expression via mTOR signaling and HIF-1 alpha in cancer cells and might lead to insights into the involvement of the mTOR signal and oxygen-sensitive intracellular pathways in the maintenance of stemness in cancer stem cells.	Oxygen	210-216	prominin 1	Homo sapiens	71-76
19494350-6	2009	Patients with Chuvash polycythemia, who are homozygous for a missense mutation in the VHL gene, have multisystem pathology attributable to dysregulated oxygen homeostasis.	Oxygen	152-158	von Hippel-Lindau tumor suppressor	Homo sapiens	86-89
19653993-7	2009	)NO behave as two substrates of Cox, which promotes their oxidation with molecular oxygen as a co-substrate.	Oxygen	83-89	cytochrome c oxidase subunit 8A	Homo sapiens	32-35
19576290-7	2009	Conversely, the NO-insensitive AOX diminished electron leakage from the respiratory chain, allowing the increase of NO half-life without interrupting oxygen consumption.	Oxygen	150-156	alternative oxidase 2	Arabidopsis thaliana	31-34
20449084-4	2009	The non-coordinating PF(6)(-) anion is not bound as an ion-pair in [Ag(L)](PF(6)) (3) and the urea NH groups exhibit short contacts to carbonyl oxygen and pi-systems.	Oxygen	144-150	sperm associated antigen 17	Homo sapiens	21-26
25197067-0	2014	Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.	Oxygen	6-12	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	53-73
19644855-11	2009	CONCLUSION: Our findings indicate that hypoxia and glucocorticoid signaling converge on a single element regulating MIF; this regulatory unit is a potential interacting node for microenvironment sensing of oxygen tension and glucocorticoid action in foci of inflammation.	Oxygen	206-212	macrophage migration inhibitory factor	Homo sapiens	116-119
25184296-2	2014	The aim was to investigate expression, and regulation by oxygen, of the Apelin APJ receptor (APJ) in myocardium obtained from children undergoing corrective surgery with cardiopulmonary bypass for repair of congenital heart defects.	Oxygen	57-63	apelin receptor	Homo sapiens	79-91
19289096-9	2009	Fluorescence decay kinetics in the absence of DCMU indicated that the expression of the His(6)-tagged PsbO-1 protein restored efficient electron transfer to Q(B), while in the presence of DCMU, charge recombination between Q(A)(-) and the S(2) state of the oxygen-evolving complex occurred at near wild-type rates.	Oxygen	257-263	PS II oxygen-evolving complex 1	Arabidopsis thaliana	102-108
19303470-1	2009	OBJECTIVE: Here we investigate whether monolayer culture or culture at 21% oxygen influences activity of cytochrome c oxidase, the terminal enzyme in the respiratory chain whose activity is essential for oxidative metabolism and whether return to three dimensional (3-D) culture restores cytochrome c oxidase activity to original levels.	Oxygen	75-81	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	105-125
25184296-2	2014	The aim was to investigate expression, and regulation by oxygen, of the Apelin APJ receptor (APJ) in myocardium obtained from children undergoing corrective surgery with cardiopulmonary bypass for repair of congenital heart defects.	Oxygen	57-63	apelin receptor	Homo sapiens	79-82
25184296-6	2014	There was a significant correlation between APJ expression in myocardium resected after 10 min with both oxygen extraction ratio (p=0.021, rho= -0.523) and mixed venous oxygen saturation (p=0.028, rho 0.52).	Oxygen	105-111	apelin receptor	Homo sapiens	44-47
25184296-6	2014	There was a significant correlation between APJ expression in myocardium resected after 10 min with both oxygen extraction ratio (p=0.021, rho= -0.523) and mixed venous oxygen saturation (p=0.028, rho 0.52).	Oxygen	169-175	apelin receptor	Homo sapiens	44-47
19820304-6	2009	Our experiments indicated that VIN3 is required for the survival of Arabidopsis seedlings exposed to low oxygen conditions.	Oxygen	105-111	Fibronectin type III domain-containing protein	Arabidopsis thaliana	31-35
24120094-5	2014	METHODS: In a sample of 1445 adolescents we tested the effect of 23-tagging single nucleotide polymorphisms across the OXTR region and stressful life events (SLEs) on functional magnetic resonance imaging blood oxygen level-dependent activity in the VS and amygdala to animated angry faces.	Oxygen	211-217	oxytocin receptor	Homo sapiens	119-123
19820304-7	2009	We suggested that the function of VIN3 during low oxygen conditions is likely to involve the mediation of chromatin modifications at certain loci that help the survival of Arabidopsis in response to prolonged hypoxia.	Oxygen	50-56	Fibronectin type III domain-containing protein	Arabidopsis thaliana	34-38
24997963-4	2014	The CB-OH adducts react with O2 either by irreversible H-abstraction to form chlorophenol and HO2 or by reversible additions to form CB-OH-O2 radicals, which subsequently cyclize to bicyclic radicals.	Oxygen	29-31	heme oxygenase 2	Homo sapiens	94-97
19597241-5	2009	Independently of its enzymatic activity in cholesterol biosynthesis, seladin-1 acts as a caspase-3 inhibitor, a mediator of response to oxidative and oncogenic stress, and a reactive oxygen species scavenger.	Oxygen	183-189	24-dehydrocholesterol reductase	Homo sapiens	69-78
19442239-3	2009	Mitochondrial ROS (reactive oxygen species), generated as a result of the interaction between nitric oxide and mitochondrial cytochrome c oxidase, activate AMPKalpha1 in HUVECs (human umbilical-vein endothelial cells) at a low oxygen concentration (i.e. 3%).	Oxygen	28-34	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	156-166
20596286-0	2009	Considerable Enhancement of Field Emission of SnO(2) Nanowires by Post-Annealing Process in Oxygen at High Temperature.	Oxygen	92-98	strawberry notch homolog 1	Homo sapiens	46-49
20596286-3	2009	Considerable enhancement of field emission of SnO(2) nanowires was obtained by a post-annealing process in oxygen at high temperature.	Oxygen	107-113	strawberry notch homolog 1	Homo sapiens	46-49
20596286-4	2009	When the SnO(2) nanowires were post-annealed at 1,000 degrees C in oxygen, the turn-on and threshold field were decreased to 3.77 and 4.4 V/mum, respectively, and the current density was increased to 6.58 from 0.3 mA/cm(2) at the same applied electric field of 5.0 V/mum.	Oxygen	67-73	strawberry notch homolog 1	Homo sapiens	9-12
17174302-5	2007	Decreased lenticular optical quality and decreased catalase and Na, K-ATPase activities were observed in lenses exposed to hyperbaric oxygen.	Oxygen	134-140	catalase	Bos taurus	51-59
17174302-10	2007	High oxygen load has toxic effects on bovine lenses in organ culture conditions as determined by optical parameters as well as reduction of catalase and Na, K-ATPase activities.	Oxygen	5-11	catalase	Bos taurus	140-148
16806535-10	2007	Oxygen therapy significantly decreased AHI and 4 serum BNP levels (from 91.75+/-80.35 pg/ml to 52.75+/-45.70 pg/ml, mean change=33.85 pg/ml, P=0.0208).	Oxygen	0-6	natriuretic peptide B	Homo sapiens	55-58
24825124-3	2014	Unlike the other known SODs (MnSOD, FeSOD, and (CuZn)SOD), which utilize "typical" biological nitrogen and oxygen donors, NiSOD utilizes a rather unexpected ligand set.	Oxygen	107-113	superoxide dismutase 2	Homo sapiens	29-34
17093294-6	2007	Application of our method to deplete RIP140 in primary mouse WAT elicited markedly increased oxygen consumption and expression of UCP1 that exactly mimics the phenotype observed in RIP140-null mice.	Oxygen	93-99	nuclear receptor interacting protein 1	Mus musculus	37-43
19375411-3	2009	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive oxygen consumption by nearly half, and addition at the end of the reaction released nearly half of the consumed oxygen by AOX, both typical of catalase action on H(2)O(2).	Oxygen	109-115	LOC102577773	Solanum tuberosum	12-20
19375411-3	2009	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive oxygen consumption by nearly half, and addition at the end of the reaction released nearly half of the consumed oxygen by AOX, both typical of catalase action on H(2)O(2).	Oxygen	221-227	LOC102577773	Solanum tuberosum	12-20
19375411-3	2009	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive oxygen consumption by nearly half, and addition at the end of the reaction released nearly half of the consumed oxygen by AOX, both typical of catalase action on H(2)O(2).	Oxygen	221-227	LOC102577773	Solanum tuberosum	252-260
25062272-0	2014	Nox4: a hydrogen peroxide-generating oxygen sensor.	Oxygen	37-43	NADPH oxidase 4	Homo sapiens	0-4
19403143-4	2009	The adsorption experiments of toxic pollutants were carried out in batch reactors at 25 degrees C. The characterization of modified CNx by these techniques showed an increase in oxygen content and surface area in comparison with the pristine CNx tubes.	Oxygen	178-184	calnexin	Homo sapiens	132-135
17264017-3	2007	This study examined the hypothesis that SMA-SRACR-induced downregulation of renal blood flow and function is more severe than renal-SRACR owing to the addition of systemic oxygen-derived free radical (ODFR) release.	Oxygen	172-178	survival of motor neuron 1, telomeric	Homo sapiens	40-43
25062272-1	2014	Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active.	Oxygen	109-115	NADPH oxidase 4	Homo sapiens	0-4
19388662-3	2009	Among reactions under oxygen-lean conditions, CF(3) + Al --&gt; CF(2) + AlF channel is the fastest, followed by the CF(2) + Al --&gt; CF + AlF and CF + Al --&gt; C + AlF channels.	Oxygen	22-28	afamin	Homo sapiens	72-75
19388662-3	2009	Among reactions under oxygen-lean conditions, CF(3) + Al --&gt; CF(2) + AlF channel is the fastest, followed by the CF(2) + Al --&gt; CF + AlF and CF + Al --&gt; C + AlF channels.	Oxygen	22-28	afamin	Homo sapiens	139-142
17101781-1	2007	Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-alpha) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in oxygen (O(2))-replete cells.	Oxygen	197-202	von Hippel-Lindau tumor suppressor	Homo sapiens	116-120
19388662-3	2009	Among reactions under oxygen-lean conditions, CF(3) + Al --&gt; CF(2) + AlF channel is the fastest, followed by the CF(2) + Al --&gt; CF + AlF and CF + Al --&gt; C + AlF channels.	Oxygen	22-28	afamin	Homo sapiens	139-142
25062272-7	2014	Critically, Nox4 has an unusually high Km for oxygen (~18%), similar to the values of known oxygen-sensing enzymes, compared with a Km of 2-3% for Nox2, the phagocyte NADPH oxidase.	Oxygen	46-52	NADPH oxidase 4	Homo sapiens	12-16
17217465-3	2007	Both PsbO proteins were able to support the oxygen evolution activity of PSII, although PsbO2 was less efficient than PsbO1 under photoinhibitory conditions.	Oxygen	44-50	photosystem II subunit O-2	Arabidopsis thaliana	88-93
19225052-8	2009	Our results demonstrate that renal I/R induces early iNOS-dependent microvascular hypoxia in disrupting the balance between microvascular oxygen supply and Vo(2)(ren), whereas endothelial NO synthase activity is compulsory for the maintenance of this balance.	Oxygen	138-144	renin	Rattus norvegicus	29-32
17217465-3	2007	Both PsbO proteins were able to support the oxygen evolution activity of PSII, although PsbO2 was less efficient than PsbO1 under photoinhibitory conditions.	Oxygen	44-50	PS II oxygen-evolving complex 1	Arabidopsis thaliana	118-123
25062272-7	2014	Critically, Nox4 has an unusually high Km for oxygen (~18%), similar to the values of known oxygen-sensing enzymes, compared with a Km of 2-3% for Nox2, the phagocyte NADPH oxidase.	Oxygen	92-98	NADPH oxidase 4	Homo sapiens	12-16
25062272-8	2014	This allows Nox4 to generate H2O2 as a function of oxygen concentration throughout a physiological range of pO2 values and to respond rapidly to changes in pO2.	Oxygen	51-57	NADPH oxidase 4	Homo sapiens	12-16
24887114-9	2014	We also found that relative maximal oxygen consumption was significantly greater in male endurance athletes with the AGTR2 C allele compared with AGTR2 A allele carriers [n = 28; 62.3 (4.4) versus 57.4 (6.0) ml min(-1) kg(-1); P = 0.0197].	Oxygen	36-42	angiotensin II receptor type 2	Homo sapiens	117-122
17212413-2	2007	Two different oxygen signals, corresponding to Bronsted acid sites in supercages and sodalite cages of zeolite HY were readily resolved in the two-dimensional (2-D) 1H-17O heteronuclear correlation (HETCOR) NMR spectra allowing the 17O isotropic chemical shift (deltaCS) and quadrupolar coupling parameters (quadrupolar coupling constant, QCC, and asymmetry parameter, eta) for the two oxygen atoms to be extracted.	Oxygen	14-20	endothelin receptor type A	Homo sapiens	369-372
17201391-0	2007	Reaction of O2 with the hydrogen atom in water up to 350 degrees C. The reaction of the H* atom with O2, giving the hydroperoxyl HO2* radical, has been investigated in pressurized water up to 350 degrees C using pulse radiolysis and deep-UV transient absorption spectroscopy.	Oxygen	101-103	heme oxygenase 2	Homo sapiens	129-132
16940473-0	2007	Oxygen regulation of macrophage migration inhibitory factor in human placenta.	Oxygen	0-6	macrophage migration inhibitory factor	Homo sapiens	21-59
16940473-7	2007	Exposure of villous explants to 3% O(2) resulted in increased MIF expression and secretion relative to standard conditions (20% O(2)).	Oxygen	35-39	macrophage migration inhibitory factor	Homo sapiens	62-65
19358330-10	2009	The production of FGF2 was enhanced 2.1-fold in FGFR-Tg-ECs under 1% oxygen via the Src/Akt/HIF1alpha pathway, which induced the peri-vessel migration of vascular smooth muscle cells (VSMCs) and anti-apoptotic effects on VSMCs and cardiomyocytes.	Oxygen	69-75	fibroblast growth factor 2	Mus musculus	18-22
19723471-4	2009	For luciferase-based reporters, we hypothesized that the oxygen-dependent destruction domain (ODD) from hypoxia-inducible factor 1 alpha (HIF-1 alpha) may provide improved sensitivity over luciferase-ODC, owing to its extremely rapid turnover by the proteasome (HIF-1 alpha has a half-life of less than 5 minutes).	Oxygen	57-63	ornithine decarboxylase 1	Homo sapiens	200-203
19158125-9	2009	Voluntary contraction strength per unit of RF(CSA) was dependent on central quadriceps activation and peripheral oxygen saturation in COPD.	Oxygen	113-119	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	43-50
19262507-4	2009	GLB-5 acts with the atypical soluble guanylate cyclases, which are a different type of oxygen binding protein, to tune the dynamic range of oxygen-sensing neurons close to atmospheric (21%) concentrations.	Oxygen	87-93	GLOBIN domain-containing protein	Caenorhabditis elegans	0-5
24925978-1	2014	Myoglobin (Mb) is an oxygen-binding muscular hemeprotein regulated via Ca(2+)-signaling pathways involving calcineurin (CN), with Mb increases attributed to hypoxia, exercise, and nitric oxide.	Oxygen	21-27	myoglobin	Rattus norvegicus	0-9
18394828-0	2009	Oxygen tension and medium type actions on blastocyst development and interferon-tau secretion in cattle.	Oxygen	0-6	interferon tau-2	Bos taurus	69-83
18394828-6	2009	IFNT concentrations in conditioned medium were similar for blastocysts cultured in M199 or KSOM, but blastocysts incubated in 5% oxygen produced less (P&lt;0.001) IFNT than their 20% oxygen counterparts.	Oxygen	129-135	interferon tau-2	Bos taurus	163-167
18394828-9	2009	In conclusion, culturing blastocysts of cattle in a 5% oxygen environment with M199 containing serum sustains embryo viability and permits constitutive and inducible IFNT production.	Oxygen	55-61	interferon tau-2	Bos taurus	166-170
18394828-10	2009	Incubation in 20% oxygen increases IFNT production.	Oxygen	18-24	interferon tau-2	Bos taurus	35-39
16940473-9	2007	In situ hybridization and immunohistochemistry showed elevated MIF expression in low oxygen-induced extravillous trophoblast cells.	Oxygen	85-91	macrophage migration inhibitory factor	Homo sapiens	63-66
17640365-0	2007	Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture.	Oxygen	99-105	SRY-box transcription factor 9	Homo sapiens	75-79
24925978-1	2014	Myoglobin (Mb) is an oxygen-binding muscular hemeprotein regulated via Ca(2+)-signaling pathways involving calcineurin (CN), with Mb increases attributed to hypoxia, exercise, and nitric oxide.	Oxygen	21-27	myoglobin	Rattus norvegicus	11-13
17640365-3	2007	In aggregate culture of outer meniscus cells, hypoxia (5% oxygen) increased the expression of type II collagen and SOX9 (Sry-related HMG box-9), and decreased the expression of type I collagen.	Oxygen	58-64	SRY-box transcription factor 9	Homo sapiens	115-119
17640365-3	2007	In aggregate culture of outer meniscus cells, hypoxia (5% oxygen) increased the expression of type II collagen and SOX9 (Sry-related HMG box-9), and decreased the expression of type I collagen.	Oxygen	58-64	SRY-box transcription factor 9	Homo sapiens	121-142
19722378-2	2009	OBJECTIVES: We sought to analyze exercise-derived mean pulmonary artery pressure (mPAP)-cardiac index (CI) relationship to expand the concepts regarding its nature and to better identify pulmonary hemodynamic responders to acute oxygen breathing (AO2B-99.5%) and to hydralazine (H) in extrinsic allergic alveolitis (EAA) and chronic interstitial lung disease (CILD) pulmonary hypertension (PH) patients.	Oxygen	229-235	phospholipid phosphatase 1	Mus musculus	82-86
24718288-7	2014	Larger P300 amplitudes indicated higher ventral striatum blood oxygen level dependent (BOLD) response.	Oxygen	63-69	E1A binding protein p300	Homo sapiens	7-11
18821853-0	2009	Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2.	Oxygen	11-17	matrix metallopeptidase 2	Rattus norvegicus	172-198
17225483-0	2007	B-type natriuretic peptide in healthy subjects after exposure to hyperbaric oxygen at 2.5 ATA.	Oxygen	76-82	natriuretic peptide B	Homo sapiens	0-26
25233517-5	2014	He was one of the first anywhere to organize a pulmonary rehabilitation program and to show the beneficial effects of long-term oxygen therapy in COPD.	Oxygen	128-134	COPD	Homo sapiens	146-150
17135366-6	2007	Finally, PHB overexpression decreases accumulation of reactive oxygen metabolites, as well as increased permeability induced by oxidative stress in intestinal epithelial cells.	Oxygen	63-69	prohibitin 1	Homo sapiens	9-12
19335616-4	2009	This mutant showed an increased sensitivity to a high concentration of oxygen, and decreased longevity at 20 degrees C but not at 26 degrees C. The genetic analysis has revealed that oxy-4 had a causative mutation in an [FeFe]-hydrogenase-like gene (Y54H5A.4).	Oxygen	71-77	putative cytosolic Fe-S cluster assembly factor oxy-4	Caenorhabditis elegans	183-188
19335616-5	2009	In the yeast Saccharomyces cerevisiae, a deletion of NAR1, a possible homologue of oxy-4, also caused a similar increased sensitivity to oxygen.	Oxygen	137-143	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	53-57
19335616-5	2009	In the yeast Saccharomyces cerevisiae, a deletion of NAR1, a possible homologue of oxy-4, also caused a similar increased sensitivity to oxygen.	Oxygen	137-143	putative cytosolic Fe-S cluster assembly factor oxy-4	Caenorhabditis elegans	83-88
25202957-5	2014	Non-pharmacological interventions, such as rehabilitation, long-term oxygen therapy, and non-invasive ventilation, are also useful strategies to prevent the acute exacerbations in patients with COPD.	Oxygen	69-75	COPD	Homo sapiens	194-198
19166505-9	2009	Human 3K3A-APC had by fivefold greater cytoprotective activity than murine 3K3A-APC in oxygen-glucose deprivation model in human brain endothelial cells, whereas murine 3K3A-APC was by 2.5-fold more potent than human 3K3A-APC in a mouse model of NMDA-induced neuronal apoptosis.	Oxygen	87-93	APC regulator of WNT signaling pathway	Homo sapiens	11-14
19166505-9	2009	Human 3K3A-APC had by fivefold greater cytoprotective activity than murine 3K3A-APC in oxygen-glucose deprivation model in human brain endothelial cells, whereas murine 3K3A-APC was by 2.5-fold more potent than human 3K3A-APC in a mouse model of NMDA-induced neuronal apoptosis.	Oxygen	87-93	APC regulator of WNT signaling pathway	Homo sapiens	80-83
17198096-0	2007	Activations of nPKCepsilon and ERK1/2 were involved in oxygen-glucose deprivation-induced neuroprotection via NMDA receptors in hippocampal slices of mice.	Oxygen	55-61	mitogen-activated protein kinase 3	Mus musculus	31-37
17085510-0	2007	Physiological roles of the light, oxygen, or voltage domains of phototropin 1 and phototropin 2 in Arabidopsis.	Oxygen	34-40	phototropin 1	Arabidopsis thaliana	64-77
16980385-2	2006	The stability of the C. elegans HIF-1 protein is controlled by the evolutionarily conserved EGL-9/VHL-1 pathway for oxygen-dependent degradation.	Oxygen	116-122	von Hippel-Lindau tumor suppressor homolog	Caenorhabditis elegans	98-103
19372578-7	2009	Gene expression profiles generated by microarray analysis revealed that reducing oxygen level to 7% resulted in the up-regulation and down-regulation of a significant number of genes, with more than 140 being commonly affected among the three CD133(+) cultures.	Oxygen	81-87	prominin 1	Homo sapiens	243-248
19372578-9	2009	Thus, the data presented indicate that growth at the more physiologically relevant oxygen level of 7% enhances the stem cell-like phenotype of CD133(+) GB cells.	Oxygen	83-89	prominin 1	Homo sapiens	143-148
19334881-6	2009	In particular, a peculiar surface restructuring, involving the formation of a network of SnO(2) species, appears for large oxygen coverage.	Oxygen	123-129	strawberry notch homolog 1	Homo sapiens	89-92
24824450-5	2014	This crosstalk might lead to interference between the two signaling pathways and thus might play a role in the variety of cellular responses after exposure to AhR ligands and reduced oxygen availability.	Oxygen	183-189	aryl hydrocarbon receptor	Homo sapiens	159-162
19380283-11	2009	CONCLUSION: MP4 causes an increase of leukocytes, improves the oxygen supply of the tissue and shows no evidence of renal impairment.	Oxygen	63-69	predicted gene 4736	Mus musculus	12-15
16982690-4	2006	We report here that Tyk2-null pro-B cells are markedly deficient in basal oxygen consumption and exhibit a significant decrease in steady-state cellular ATP levels compared to wild-type cells.	Oxygen	74-80	tyrosine kinase 2	Mus musculus	20-24
25033834-4	2014	APE1/Ref-1 maintains cellular homeostasis (redox) via the activation of TFs that regulate various physiological processes and that crosstalk with redox balancing agents (for example, thioredoxin, catalase and superoxide dismutase) by controlling levels of reactive oxygen and nitrogen species.	Oxygen	265-271	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
17056719-5	2006	The sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome, including early-onset mortality and age-related behavioral decay.	Oxygen	37-43	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	4-8
19181962-3	2009	Using the mouse model of oxygen-induced proliferative retinopathy, ROCK I/II inhibition by H-1152 resulted in increased angiogenesis.	Oxygen	25-31	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	67-73
25033834-4	2014	APE1/Ref-1 maintains cellular homeostasis (redox) via the activation of TFs that regulate various physiological processes and that crosstalk with redox balancing agents (for example, thioredoxin, catalase and superoxide dismutase) by controlling levels of reactive oxygen and nitrogen species.	Oxygen	265-271	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	5-10
19254673-6	2009	Resting BNP, DLCO, and DM correlate with peak oxygen consumption (P &lt; .0001 for all analyses).	Oxygen	46-52	natriuretic peptide B	Homo sapiens	8-11
24686056-2	2014	ALOX12 catalyzes the addition of oxygen to arachidonic acid, producing 12-hydroperoxyeicosatetraenoic acid (12-HPETE), which can be reduced to the eicosanoid 12-HETE (12-hydroxyeicosatetraenoic acid).	Oxygen	33-39	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	0-6
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	40-46	egl-9 family hypoxia inducible factor 2	Homo sapiens	66-115
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	40-46	egl-9 family hypoxia inducible factor 2	Homo sapiens	117-123
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	183-189	egl-9 family hypoxia inducible factor 2	Homo sapiens	66-115
17042492-2	2006	Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4 equiv of Fe(II) to the reduction of O2 to 2 H2O.	Oxygen	127-129	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
25109087-7	2014	Hyperbaric oxygen improves mitochondrial function, inhibits lipid peroxidation transiently, impairs leukocyte adhesion to injured microvasculature, and reduces brain inflammation caused by the CO-induced adduct formation of myelin basic protein.	Oxygen	11-17	myelin basic protein	Homo sapiens	224-244
16966387-9	2006	In axial muscle, expression of the "slow" types of myosin and troponin C was increased, together with expression of erythropoietin and myoglobin, which enhance oxygen transport, indicating a shift toward a slow aerobic phenotype.	Oxygen	160-166	myoglobin	Danio rerio	135-144
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	183-189	egl-9 family hypoxia inducible factor 2	Homo sapiens	117-123
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	183-189	egl-9 family hypoxia inducible factor 2	Homo sapiens	66-115
19165233-4	2009	The recent discovery of a new family of oxygen sensors--including prolyl hydroxylase domain-containing proteins 1-3 (PHD1-3)--has yielded exciting novel insights into how cells sense oxygen and keep oxygen supply and consumption in balance.	Oxygen	183-189	egl-9 family hypoxia inducible factor 2	Homo sapiens	117-123
19160195-2	2009	Acute exacerbations of COPD, usually related to superimposed infection, occur commonly and systemic corticosteroids are widely used in their management in combination with other treatments including antibiotics, oxygen supplementation and bronchodilators.	Oxygen	212-218	COPD	Homo sapiens	23-27
17328145-10	2006	beta3-adrenergic oxygen-derived free radical production might be important in situations of enhanced beta3-adrenoceptor activation, as has been described in human heart failure.	Oxygen	17-23	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	0-5
25262689-13	2014	The LDH, CEA and SP-A levels correlated positively with P(A-a) O2 and negatively with TL(CO)%, PaO2 and SaO2 (P &lt; 0.05).	Oxygen	63-65	surfactant protein A1	Homo sapiens	17-21
16844086-4	2006	For further studies concerning transplantation therapy, the point substitution, Ser147Cys, that resulted in a single atom change, oxygen to sulfur, designated as HLA-Ev(147), led to a much higher expression on the human and pig cell surface and a greater inhibitory function against human NK cells than wild type HLA-E in an in vitro model system of pig to human xenotransplantation.	Oxygen	130-136	major histocompatibility complex, class I, E	Homo sapiens	162-167
16835250-6	2006	Reporter assays reveal that the CXCL12 promoter activity is enhanced in LNT-229 cells at 24 h after irradiation at 8 Gy or after exposure to 1% oxygen for 12 h. The irradiation- and hypoxia-induced release of CXCL12 depends on hypoxia inducible factor-1 alpha (HIF-1alpha), but not on p53.	Oxygen	144-150	chemokine (C-X-C motif) ligand 12	Mus musculus	32-38
16835250-6	2006	Reporter assays reveal that the CXCL12 promoter activity is enhanced in LNT-229 cells at 24 h after irradiation at 8 Gy or after exposure to 1% oxygen for 12 h. The irradiation- and hypoxia-induced release of CXCL12 depends on hypoxia inducible factor-1 alpha (HIF-1alpha), but not on p53.	Oxygen	144-150	chemokine (C-X-C motif) ligand 12	Mus musculus	209-215
19026614-1	2009	The protein kinase-mediated actions of peptide growth factors such as IGF-1 and bFGF protect cultured neurons from being killed by the oxygen and glucose deprivations (OGD) that prevail in the "stroked brain".	Oxygen	135-141	fibroblast growth factor 2	Rattus norvegicus	80-84
18924149-5	2009	This effect was also seen in tumor-bearing mice continuously breathing 7% oxygen for 3 hr which markedly increased the extent of EF5 positive labeling.	Oxygen	74-80	angiogenin, ribonuclease A family, member 3	Mus musculus	129-132
19925433-6	2009	MiR-210 also participates in endothelial and neuronal cells" response to oxygen deprivation and may possess a role in the regulation of angiogenesis.	Oxygen	73-79	microRNA 210	Homo sapiens	0-7
19205974-0	2009	A new alpha-globin variant with increased oxygen affinity in a Swiss family: Hb Frauenfeld [alpha 138(H21)Ser-->Phe, TCC>TTC (alpha 2)].	Oxygen	42-48	hemoglobin subunit alpha 2	Homo sapiens	6-18
16877351-7	2006	mRNA levels of type II collagen (Col2A1) and the beta-subunit (P4HB) of prolyl-4-hydroxylase, however, displayed only modest changes at 1% oxygen.	Oxygen	139-145	prolyl 4-hydroxylase subunit beta	Homo sapiens	63-67
24936260-6	2014	Genetically manipulated mice devoid of PKCbeta are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity.	Oxygen	71-77	protein kinase C, beta	Mus musculus	39-46
16901919-5	2006	This PEDF effect was confirmed in the retina of rats with oxygen-induced retinopathy.	Oxygen	58-64	serpin family F member 1	Rattus norvegicus	5-9
16846241-5	2006	Inactivation of glutaredoxin required the reduced (dithiol) form of the enzyme, the oxidized (intramolecular disulfide) form of sporidesmin, and molecular oxygen.	Oxygen	155-161	glutaredoxin	Homo sapiens	16-28
19378255-1	2009	The globin family, including hemoglobin, myoglobin, neuroglobin and cytoglobin, plays an important role in oxygen storage and delivery.	Oxygen	107-113	myoglobin	Danio rerio	41-50
19378255-1	2009	The globin family, including hemoglobin, myoglobin, neuroglobin and cytoglobin, plays an important role in oxygen storage and delivery.	Oxygen	107-113	neuroglobin	Danio rerio	52-63
24613515-16	2014	CONCLUSIONS: Analytical results prove that the GDH-based monitors tolerate a broad BG concentration range, are oxygen independent, have BG specificity, and have minimal interference from hematocrit.	Oxygen	111-117	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	47-50
19151537-3	2009	The expression of HIF alpha-chains is post-translationally regulated and hydroxylation at one or two of the conserved proline residues by prolyl-hydroxylase domains (PHDs) is a critical step for the oxygen-dependent recruitment of the von Hippel-Lindau gene product (pVHL), a recognition component of the E3 ubiquitin ligase complex, and degradation of HIF-alpha.	Oxygen	199-205	von Hippel-Lindau tumor suppressor	Homo sapiens	267-271
16740253-1	2006	Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF).	Oxygen	29-35	heme oxygenase 2	Homo sapiens	200-204
24644296-11	2014	The adsorption of NH3 as a probe molecule indicates that the acidity can affect the hydrogen-bonding interaction between (N-H   O2) and (N   H-O2).	Oxygen	128-130	heme oxygenase 2	Homo sapiens	141-145
16611863-10	2006	EGLN1, EGLN2, and EGLN3 were also temporally expressed in an oxygen-dependent fashion, with greatest mRNA expression at 10-12 wk of gestation.	Oxygen	61-67	egl-9 family hypoxia inducible factor 2	Homo sapiens	7-12
19348906-1	2009	Cytochrome b is a pivotal protein subunit of the cytochrome bc(1) complex and forms the ubiquinol oxidation site in the enzyme that is generally thought to be the primary site where electrons are aberrantly diverted from the enzyme, reacting with oxygen to form superoxide anion.	Oxygen	247-253	cytochrome b	Saccharomyces cerevisiae S288C	0-12
19348906-2	2009	In addition, recent studies have shown that mutations in cytochrome b can substantially increase rates of oxygen radical formation by the bc(1) complex.	Oxygen	106-112	cytochrome b	Saccharomyces cerevisiae S288C	57-69
19348906-3	2009	It would, thus, be advantageous to be able to manipulate cytochrome b by mutagenesis of the cytochrome b gene to better understand the role of cytochrome b in oxygen radical formation.	Oxygen	159-165	cytochrome b	Saccharomyces cerevisiae S288C	57-69
19348906-3	2009	It would, thus, be advantageous to be able to manipulate cytochrome b by mutagenesis of the cytochrome b gene to better understand the role of cytochrome b in oxygen radical formation.	Oxygen	159-165	cytochrome b	Saccharomyces cerevisiae S288C	92-104
24500242-2	2014	By contrast with the general reductive oxygen activation pathway of P450s, an H2O2-shunt pathway does not require any supply of electrons and protons for the generation of a highly reactive intermediate (compound I).	Oxygen	39-45	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-73
19348906-3	2009	It would, thus, be advantageous to be able to manipulate cytochrome b by mutagenesis of the cytochrome b gene to better understand the role of cytochrome b in oxygen radical formation.	Oxygen	159-165	cytochrome b	Saccharomyces cerevisiae S288C	92-104
19123529-4	2008	On the basis of photoluminescence quenching analysis and of first-principles calculations we show that surface bridging oxygen vacancies in SnO(2) lead to formation of occupied and empty surface bands whose transition energies are in strong agreement with luminescence features and whose luminescence activity can be switched off by surface adsorption of oxidizing molecules.	Oxygen	120-126	strawberry notch homolog 1	Homo sapiens	140-143
16749848-3	2006	In these compounds, LH2 refers to the tetraiminodiphenol macrocycle in the zwitterionic form whose two uncoordinated imine nitrogens are protonated and hydrogen-bonded to the metal-bound phenolate oxygens.	Oxygen	197-204	LIM homeobox 2	Homo sapiens	20-23
16600997-4	2006	Although Kv 1.3 channels play a key role in T cell O(2) sensing, the signalling mechanisms mediating their response to hypoxia are still not understood.	Oxygen	51-55	potassium voltage-gated channel subfamily A member 3	Homo sapiens	9-15
16600997-12	2006	Our findings indicate that Lck is required for the acute response to hypoxia of human T lymphocytes as it is necessary to confer O(2) sensitivity on Kv 1.3 channels.	Oxygen	129-133	potassium voltage-gated channel subfamily A member 3	Homo sapiens	149-155
24798657-5	2014	Sleep SBP surge (difference between the hypoxia-peak SBP measured by oxygen-triggered function and SBPs within 30 minutes before and after the peak SBP) was only significantly reduced by carvedilol (P&lt;.05).	Oxygen	69-75	selenium binding protein 1	Homo sapiens	6-9
16722709-6	2006	The complex was found to have a strong hydrogen bond (D(e) = 43.9 kJ mol(-1)) with the hydrogen in HO2 binding to the oxygen in CH3OH.	Oxygen	118-124	heme oxygenase 2	Homo sapiens	99-102
16634620-1	2006	myo-Inositol oxygenase (MIOX) uses iron as its cofactor and dioxygen as its cosubstrate to effect the unique, ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.	Oxygen	60-68	myo-inositol oxygenase	Homo sapiens	4-22
16634620-1	2006	myo-Inositol oxygenase (MIOX) uses iron as its cofactor and dioxygen as its cosubstrate to effect the unique, ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.	Oxygen	60-68	myo-inositol oxygenase	Homo sapiens	24-28
16634620-3	2006	The data demonstrate the formation of an antiferromagnetically coupled, high-spin diiron(III/III) cluster upon treatment of solutions of Fe(II) and MIOX with excess O(2) or H(2)O(2) and the formation of an antiferromagnetically coupled, valence-localized, high-spin diiron(II/III) cluster upon treatment with either limiting O(2) or excess O(2) in the presence of a mild reductant (e.g., ascorbate).	Oxygen	165-169	myo-inositol oxygenase	Homo sapiens	148-152
16634621-0	2006	Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase.	Oxygen	0-6	myo-inositol oxygenase	Homo sapiens	109-127
16634621-10	2006	The use of the mixed-valent, diiron(II/III) cluster by MIOX represents a significant departure from the mechanisms of other known diiron oxygenases, which all involve activation of O(2) from the II/II manifold.	Oxygen	181-185	myo-inositol oxygenase	Homo sapiens	55-59
24798657-5	2014	Sleep SBP surge (difference between the hypoxia-peak SBP measured by oxygen-triggered function and SBPs within 30 minutes before and after the peak SBP) was only significantly reduced by carvedilol (P&lt;.05).	Oxygen	69-75	selenium binding protein 1	Homo sapiens	53-56
16790083-4	2006	We have previously shown that Met activation by HGF/SF increases oxygen consumption in vitro and results in substantial alteration of blood oxygenation levels in vivo, as measured by blood oxygenation level-dependent magnetic resonance imaging.	Oxygen	65-71	hepatocyte growth factor	Homo sapiens	48-54
24798657-5	2014	Sleep SBP surge (difference between the hypoxia-peak SBP measured by oxygen-triggered function and SBPs within 30 minutes before and after the peak SBP) was only significantly reduced by carvedilol (P&lt;.05).	Oxygen	69-75	selenium binding protein 1	Homo sapiens	53-56
24486555-2	2014	Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms.	Oxygen	149-155	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	0-5
16288478-1	2006	Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes.	Oxygen	81-87	carbonic anhydrase 9	Homo sapiens	101-122
16288478-1	2006	Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes.	Oxygen	81-87	carbonic anhydrase 9	Homo sapiens	124-129
24695395-10	2014	Blockage of galectin-3 activity by N-acetyllactosamine (LacNac 10 mmol/l) reduced both collagen I and O2(*-) production induced by leptin.	Oxygen	102-104	leptin	Rattus norvegicus	131-137
16581766-4	2006	In this study, we found that O(2) also was permissive for IL-1 induction of SP-A expression and for cAMP and IL-1 stimulation of type II cell nuclear protein binding to the TBE.	Oxygen	29-33	surfactant protein A1	Homo sapiens	76-80
16581766-5	2006	Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia.	Oxygen	94-98	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
24623849-5	2014	In the absence of Rubisco and PGR5, a sustained electron flow is maintained with molecular oxygen instead of carbon dioxide serving as the terminal electron acceptor.	Oxygen	91-97	proton gradient regulation 5	Arabidopsis thaliana	30-34
16581766-5	2006	Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia.	Oxygen	94-98	nuclear receptor coactivator 1	Homo sapiens	165-195
16581766-5	2006	Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia.	Oxygen	94-98	surfactant protein A1	Homo sapiens	221-225
16581766-8	2006	These results, together with findings that the histone deacetylase inhibitor trichostatin A and the methyltransferase inhibitor 5"-deoxy(5"-methylthio)adenosine markedly enhanced SP-A expression in lung type II cells, suggest that increased O(2) availability to type II cells late in gestation causes epigenetic changes that permit access of TTF-1 and NF-kappaB to the SP-A promoter.	Oxygen	241-245	surfactant protein A1	Homo sapiens	179-183
24026964-6	2014	In the former group, there was a positive correlation between the 3% oxygen desaturation index on diagnostic polysomnogram and the increase of rCBF after CPAP treatment in the frontal lobe.	Oxygen	69-75	CCAAT/enhancer binding protein zeta	Rattus norvegicus	143-147
16536556-1	2006	Intersubunit intramolecular electron transfer (IET) from FMN to heme is essential in the delivery of electrons required for O2 activation in the heme domain and the subsequent nitric oxide (NO) synthesis by NO synthase (NOS).	Oxygen	124-126	nitric oxide synthase 1, neuronal	Mus musculus	207-218
24554521-4	2014	The CNT/HDC nanostructures are highly active electrocatalysts for the oxygen reduction reaction and displayed one of the best performances among heteroatom-doped nanocarbon catalysts in terms of half-wave potential and kinetic current density.	Oxygen	70-76	histidine decarboxylase	Homo sapiens	8-11
16396931-2	2006	Here we report that ion currents mediated by Ca2+-activated K+ (K(Ca)) channels in human melanoma IGR1 cells are increased by chronic hypoxia (3% O2), as well as by hypoxia mimetics.	Oxygen	146-148	casein kappa	Homo sapiens	64-69
24554704-7	2014	We found that a high O2 condition repressed Notch-dependent gene Hes1 expression and increased Ngn3 expression at the stage of pancreatic progenitors.	Oxygen	21-23	hes family bHLH transcription factor 1	Homo sapiens	65-69
16226770-9	2006	Data presented herein also demonstrate that low oxygen tension decreases AhR activation and signaling and increases the inherent toxicity of TCDD.	Oxygen	48-54	aryl hydrocarbon receptor	Homo sapiens	73-76
24630601-3	2014	We hypothesized that EPOR signaling is important in pathological angiogenesis and tested this hypothesis using a rat model of oxygen-induced retinopathy that is representative of human retinopathy of prematurity.	Oxygen	126-132	erythropoietin receptor	Rattus norvegicus	21-25
16606017-2	2006	The adhesion energy at this interface (E(adh,ox/m)) provides extra stabilization, which lowers the O2 pressure required for oxide stability as a thin film below that required for bulk-oxide stability by the factor exp[(2gamma(g/ox) - E(adh,ox/m))/(tN(ox)RT)], where gamma(g/ox) is the surface energy of the oxide, t is the oxide film thickness, and N(ox) is the oxygen concentration in the bulk oxide (moles O2 per volume).	Oxygen	99-101	muscleblind like splicing regulator 1	Homo sapiens	214-217
16606017-2	2006	The adhesion energy at this interface (E(adh,ox/m)) provides extra stabilization, which lowers the O2 pressure required for oxide stability as a thin film below that required for bulk-oxide stability by the factor exp[(2gamma(g/ox) - E(adh,ox/m))/(tN(ox)RT)], where gamma(g/ox) is the surface energy of the oxide, t is the oxide film thickness, and N(ox) is the oxygen concentration in the bulk oxide (moles O2 per volume).	Oxygen	362-368	muscleblind like splicing regulator 1	Homo sapiens	214-217
16606017-2	2006	The adhesion energy at this interface (E(adh,ox/m)) provides extra stabilization, which lowers the O2 pressure required for oxide stability as a thin film below that required for bulk-oxide stability by the factor exp[(2gamma(g/ox) - E(adh,ox/m))/(tN(ox)RT)], where gamma(g/ox) is the surface energy of the oxide, t is the oxide film thickness, and N(ox) is the oxygen concentration in the bulk oxide (moles O2 per volume).	Oxygen	408-410	muscleblind like splicing regulator 1	Homo sapiens	214-217
16460039-4	2006	In the oxidation by O2 of the fully reduced oxidase, the H+/COX ratio for proton release from COV (R --&gt; O transition) decreased from approximately 2.4 at pH 6.5 to approximately 1.8 at pH 8.5.	Oxygen	20-22	cytochrome c oxidase subunit 8A	Homo sapiens	60-63
23590434-7	2014	The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption.	Oxygen	141-147	superoxide dismutase 2	Homo sapiens	28-33
16460039-8	2006	The additional H+ release (O2 versus ferricyanide oxidation) approaching 1 H+/COX at pH &lt; or = 6.5 is associated with the reduction of O2 by the reduced metal centers.	Oxygen	27-29	cytochrome c oxidase subunit 8A	Homo sapiens	78-81
16460039-8	2006	The additional H+ release (O2 versus ferricyanide oxidation) approaching 1 H+/COX at pH &lt; or = 6.5 is associated with the reduction of O2 by the reduced metal centers.	Oxygen	138-140	cytochrome c oxidase subunit 8A	Homo sapiens	78-81
16460039-10	2006	The H+/COX ratio for proton release from COV in the overall catalytic cycle, oxidation by O2 of the fully reduced oxidase directly followed by re-reduction (R --&gt; O --&gt; R transition), exhibited a bell-shaped pH dependence approaching 4 at pH 7.2.	Oxygen	90-92	cytochrome c oxidase subunit 8A	Homo sapiens	7-10
24526696-7	2014	EVCs differentiated in 5% O2 exhibited an increased expression of vascular endothelial cadherin and CD31 along with their localization to the membrane, enhanced lectin binding and acetylated low-density lipoprotein uptake, rapid cord-like structure formation, and increased expression of arterial endothelial cell markers.	Oxygen	26-28	platelet and endothelial cell adhesion molecule 1	Homo sapiens	100-104
16448106-1	2006	Progressive isomorphous incorporation of TiIV (or BIII) heteroatoms into the MFI structure of as-synthesized silicalite-1 caused a decrease in the amount of siloxy groups (anions), requisite for counter-balancing the structural directing agent (cation), as determined using 1H MAS NMR to quantify the silanol protons H-bonded to the siloxy oxygen.	Oxygen	340-346	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	50-54
16139409-10	2006	The further mutational analysis demonstrated that the ARD1-acetylated motif near the C-terminal degradation domain (CDD) modulates the oxygen-dependent regulation of HIF-1alpha.	Oxygen	135-141	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	54-58
24508277-0	2014	F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.	Oxygen	80-86	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	erb-b2 receptor tyrosine kinase 4	Homo sapiens	34-38
24508277-5	2014	In addition, the FBXL5-Hr domain also senses O2 availability, albeit by a distinct mechanism.	Oxygen	45-47	F-box and leucine-rich repeat protein 5	Mus musculus	17-22
16352305-3	2006	We show here that GH can stimulate cellular oxygen consumption in CHO cells transfected with cDNA coding for the full-length GHR.	Oxygen	44-50	growth hormone receptor	Cricetulus griseus	125-128
24508277-9	2014	Here, we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology.	Oxygen	31-37	F-box and leucine-rich repeat protein 5	Mus musculus	64-69
24492964-6	2014	Prolonged silencing of TID1 or low-dose oligomycin treatment leads to the loss of mtDNA and the consequent inhibition of oxygen consumption.	Oxygen	121-127	DnaJ heat shock protein family (Hsp40) member A3	Homo sapiens	23-27
16430787-9	2006	RESULTS: The O2 dissociation curve (ODC) of Mb, when the effluent buffer O2 pressure was used as the abscissa, was of a sigmoid shape under normal and increased respiratory conditions whereas it was of rectangular hyperbolic shape under a suppressed respiratory condition.	Oxygen	73-75	myoglobin	Rattus norvegicus	44-46
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	48-50	myoglobin	Rattus norvegicus	96-98
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	48-50	myoglobin	Rattus norvegicus	172-174
19046553-6	2008	Levels of KL-6 both in BALF and blood were significantly correlated with serum lactate dehydrogenase level, arterial oxygen tension, and alveolar-arterial gradient in partial pressure of oxygen, the severity markers for iPAP, and were significantly higher in patients with iPAP who required subsequent therapeutic lung lavage.	Oxygen	117-123	mucin 1, cell surface associated	Homo sapiens	10-14
19046553-6	2008	Levels of KL-6 both in BALF and blood were significantly correlated with serum lactate dehydrogenase level, arterial oxygen tension, and alveolar-arterial gradient in partial pressure of oxygen, the severity markers for iPAP, and were significantly higher in patients with iPAP who required subsequent therapeutic lung lavage.	Oxygen	187-193	mucin 1, cell surface associated	Homo sapiens	10-14
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	96-98
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	172-174
24608041-6	2014	Deletion of Mir210 promoted TH17 differentiation under conditions of limited oxygen.	Oxygen	77-83	microRNA 210	Homo sapiens	12-18
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	96-98
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	172-174
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	96-98
16430787-11	2006	These observations indicate that an increase in O2 demand in tissues makes the O2 saturation of Mb more sensitive to O2 pressure change in the capillaries and enhances the Mb-mediated O2 transfer from Hb to cytochrome oxidase (Cyt.	Oxygen	79-81	myoglobin	Rattus norvegicus	172-174
16430787-13	2006	CONCLUSION: The virtual cooperativity and O2 demand-dependent shifts of the ODC may provide a basis for explaining why Mb has been preserved as monomer during molecular evolution.	Oxygen	42-44	myoglobin	Rattus norvegicus	119-121
16112902-5	2006	BNP and NT-proBNP levels correlated with peak oxygen consumption (VO2) (both R = -0.53, p &lt; 0.001), VE/VCO2 slope (R = 0.56; p &lt; 0.001 and R = 0.58; p &lt; 0.001, respectively) and maximum workload (R = -0.49; p &lt; 0.001 and R = -0.47; p &lt; 0.001, respectively).	Oxygen	46-52	natriuretic peptide B	Homo sapiens	0-3
18852288-7	2008	Partial inactivation of GTPBP3 by small interfering RNA reduces oxygen consumption, ATP production, and mitochondrial protein synthesis, while the degradation of these proteins slightly increases.	Oxygen	64-70	GTP binding protein 3, mitochondrial	Homo sapiens	24-30
18809421-4	2008	Three-hour hypoxia (1% O2) and consequent 24-h reoxygenation significantly increased the apoptotic death of hippocampal neurons as evidenced by increases in both TUNEL-positive cell number and caspase-3 activity.	Oxygen	23-25	caspase 3	Rattus norvegicus	193-202
18676622-5	2008	In Muller cell cultures, CHX treatment resulted in an increase, whereas mild hypoxia (2.5%-10% O(2)) induced a decrease, of PEDF mRNA and protein levels.	Oxygen	95-99	serpin family F member 1	Homo sapiens	124-128
18676622-6	2008	However, strong hypoxia (0.2% O(2)) induced an upregulation of PEDF mRNA expression and resulted in only slightly reduced PEDF levels after 24 hours, detected as either a released, soluble, or cell surface-linked protein.	Oxygen	30-34	serpin family F member 1	Homo sapiens	63-67
18676622-6	2008	However, strong hypoxia (0.2% O(2)) induced an upregulation of PEDF mRNA expression and resulted in only slightly reduced PEDF levels after 24 hours, detected as either a released, soluble, or cell surface-linked protein.	Oxygen	30-34	serpin family F member 1	Homo sapiens	122-126
27774464-3	2014	Here we investigated oxygen-regulated expression of Wnt-1 induced signaling protein 2 (WISP-2), which has been reported to attenuate the progression of breast cancer.	Oxygen	21-27	cellular communication network factor 5	Homo sapiens	52-85
18676622-10	2008	During severe (or chronic) oxygen deficiency, however, the PEDF decline is arrested or even reversed; thus, the neurotrophic effects of PEDF remain available.	Oxygen	27-33	serpin family F member 1	Homo sapiens	59-63
18751708-5	2008	Through its oxygen-dependent regulation of hypoxia-inducible factor alpha (HIFalpha), pVHL plays a central role in the oxygen-sensing pathway.	Oxygen	12-18	von Hippel-Lindau tumor suppressor	Homo sapiens	86-90
16298761-0	2006	Non-oxygen-forming pathways of hydrogen peroxide degradation by bovine liver catalase at low hydrogen peroxide fluxes.	Oxygen	4-10	catalase	Bos taurus	77-85
18046859-3	2006	Current COPD guidelines acknowledge that the following can improve COPD mortality: smoking cessation; long-term oxygen therapy; and lung volume reduction surgery in small subsets of COPD patients.	Oxygen	112-118	COPD	Homo sapiens	8-12
18046859-3	2006	Current COPD guidelines acknowledge that the following can improve COPD mortality: smoking cessation; long-term oxygen therapy; and lung volume reduction surgery in small subsets of COPD patients.	Oxygen	112-118	COPD	Homo sapiens	67-71
18751708-5	2008	Through its oxygen-dependent regulation of hypoxia-inducible factor alpha (HIFalpha), pVHL plays a central role in the oxygen-sensing pathway.	Oxygen	119-125	von Hippel-Lindau tumor suppressor	Homo sapiens	86-90
18046859-3	2006	Current COPD guidelines acknowledge that the following can improve COPD mortality: smoking cessation; long-term oxygen therapy; and lung volume reduction surgery in small subsets of COPD patients.	Oxygen	112-118	COPD	Homo sapiens	67-71
27774464-3	2014	Here we investigated oxygen-regulated expression of Wnt-1 induced signaling protein 2 (WISP-2), which has been reported to attenuate the progression of breast cancer.	Oxygen	21-27	cellular communication network factor 5	Homo sapiens	87-93
24613839-7	2014	ATP, mitochondrial potential and oxygen consumption increase at 3h of GLP-1 treatment, paralleled by increased Ca(2+) transfer from the ER to the mitochondria.	Oxygen	33-39	glucagon like peptide 1 receptor	Homo sapiens	70-75
16686439-3	2006	We considered the possibility that hypoxia may increase the cellular ATP/AMP ratio, increase the activity of AMP-activated protein kinase (AMPK) and thereby evoke Ca2+ signals in O2-sensing cells.	Oxygen	179-181	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	139-143
16686439-4	2006	Co-immunoprecipitation identified alpha1beta2gamma1 as the primary AMPK isozyme in pulmonary arterial smooth muscle, whilst the tissue-specific distribution of AMPK activities and their activation by hypoxia suggested that the AMPK-alpha1 catalytic subunit isoform is key to the regulation of O2-sensing cells.	Oxygen	293-295	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	227-238
18772315-0	2008	Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner.	Oxygen	100-106	kinase insert domain protein receptor	Mus musculus	24-29
18772315-5	2008	Parallel measurements of VEGF and VEGFRs demonstrated that sFlt-1 regulates VEGFR2 (Flk-1) activation in both a developmental-stage-dependent and oxygen-dependent manner.	Oxygen	146-152	kinase insert domain protein receptor	Mus musculus	76-82
18772315-5	2008	Parallel measurements of VEGF and VEGFRs demonstrated that sFlt-1 regulates VEGFR2 (Flk-1) activation in both a developmental-stage-dependent and oxygen-dependent manner.	Oxygen	146-152	kinase insert domain protein receptor	Mus musculus	84-89
24504009-0	2014	An oxygen evolution Co-Ac catalyst--the synergistic effect of phosphate ions.	Oxygen	3-9	phosphopantothenoylcysteine decarboxylase	Homo sapiens	20-25
18973699-1	2008	OBJECTIVE: We examined the hypothesis that higher cerebral oxygen saturation (rSO2) during RCP is correlated with urinary output.	Oxygen	59-65	CGRP receptor component	Homo sapiens	91-94
16437695-9	2005	sVCAM-1, sICAM-1, sE-selectin concentrations correlated negatively with the oxygen free radical production (MIF of R123) in neutrophils after PMA stimulation in liver cirrhosis patients (r-0.45, P&lt;0.05; r-0.41, P&lt;0.05; r-0.39, P&lt;0.05, respectively).	Oxygen	76-82	macrophage migration inhibitory factor	Homo sapiens	108-111
24504009-3	2014	In the present study, a cobalt acetate based oxygen evolution catalyst (Co-Ac) is prepared from a neutral acetate buffer solution, where the solubility of Co(2+) is very high (&gt;100 times in comparison with phosphate buffer solution).	Oxygen	45-51	phosphopantothenoylcysteine decarboxylase	Homo sapiens	72-77
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	194-196	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	122-127
24504009-5	2014	The comparative studies on the oxygen evolution reaction (OER) activity of Co-Ac and Co-Pi in phosphate and acetate buffer electrolytes reveal that the Co-Ac exhibits enhanced synergistic catalytic activity in phosphate solution, probably due to partial substitution of acetate in the catalyst layer by phosphate, resulting in the formation of a Co-Ac-Pi catalyst.	Oxygen	31-37	phosphopantothenoylcysteine decarboxylase	Homo sapiens	75-80
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	233-235	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	122-127
18708277-7	2008	Difference between the calculated QCC and eta(Q) values revealed how hydrogen-bonding interactions affect EFG tensors at the sites of each oxygen nucleus.	Oxygen	139-145	endothelin receptor type A	Homo sapiens	42-45
18926491-8	2008	The direct effect of O2 on PPDK gene expression provides a clue for explaining the competition between C and N metabolisms.	Oxygen	21-23	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	27-31
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	112-118	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	44-47
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	112-118	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	112-118	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	112-118	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	180-186	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	44-47
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	180-186	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	180-186	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	Oxygen	180-186	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
24504009-5	2014	The comparative studies on the oxygen evolution reaction (OER) activity of Co-Ac and Co-Pi in phosphate and acetate buffer electrolytes reveal that the Co-Ac exhibits enhanced synergistic catalytic activity in phosphate solution, probably due to partial substitution of acetate in the catalyst layer by phosphate, resulting in the formation of a Co-Ac-Pi catalyst.	Oxygen	31-37	phosphopantothenoylcysteine decarboxylase	Homo sapiens	152-157
19099877-7	2008	Under 100% O2 exposure for 72 h, it caused 7-fold decreased Gpx1 expression in Prdx6-/- mouse lung with no remarkable decrease of Prdx6 expression in Gpx1-/- mice.	Oxygen	11-13	peroxiredoxin 6	Mus musculus	79-84
24504009-5	2014	The comparative studies on the oxygen evolution reaction (OER) activity of Co-Ac and Co-Pi in phosphate and acetate buffer electrolytes reveal that the Co-Ac exhibits enhanced synergistic catalytic activity in phosphate solution, probably due to partial substitution of acetate in the catalyst layer by phosphate, resulting in the formation of a Co-Ac-Pi catalyst.	Oxygen	31-37	phosphopantothenoylcysteine decarboxylase	Homo sapiens	152-157
16223535-1	2005	We tested the hypothesis that atrial natriuretic peptide (ANP) would decrease both the effects of myocardial stunning and oxygen consumption in rabbit hearts.	Oxygen	122-128	natriuretic peptides A	Oryctolagus cuniculus	30-56
25272712-2	2014	Subjects with heterozygous genotype GC were characterized by not only increased sensation to cold but also hypometabolic response to local skin cooling and non-temperature activation of TRPM8 ion channel by menthol--decrease in total metabolism, pulmonary ventilation and coefficient of oxygen extraction.	Oxygen	287-293	transient receptor potential cation channel subfamily M member 8	Homo sapiens	186-191
16223535-1	2005	We tested the hypothesis that atrial natriuretic peptide (ANP) would decrease both the effects of myocardial stunning and oxygen consumption in rabbit hearts.	Oxygen	122-128	natriuretic peptides A	Oryctolagus cuniculus	58-61
18773991-8	2008	Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model.	Oxygen	31-37	lipoprotein(a)	Homo sapiens	103-108
16323925-0	2005	Preparation and O2 binding study of myoglobin having a cobalt porphycene.	Oxygen	16-18	myoglobin	Physeter catodon	36-45
18698765-6	2008	In contrast to the 2(Ar(X)) cases, the HHPP-adduct 2(H) reacted to give a copper(II)-acetate complex [Cu(II)(L(H))(OAc)](ClO4) (6(H)), in which one of the oxygen atoms of the acetate co-ligand originated from H2O2.	Oxygen	155-161	HHPP	Homo sapiens	39-43
24375723-0	2014	Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1alpha-mediated transcriptional regulation.	Oxygen	0-6	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	74-78
16323925-2	2005	Similar to the previously reported finding for the myoglobin with the iron porphycene, the reconstituted myoglobin with the cobalt porphycene was also found to have an O2 affinity 2 orders of magnitude greater than that of the myoglobin possessing cobalt protoporphyrin IX.	Oxygen	168-170	myoglobin	Physeter catodon	105-114
16323925-2	2005	Similar to the previously reported finding for the myoglobin with the iron porphycene, the reconstituted myoglobin with the cobalt porphycene was also found to have an O2 affinity 2 orders of magnitude greater than that of the myoglobin possessing cobalt protoporphyrin IX.	Oxygen	168-170	myoglobin	Physeter catodon	105-114
16332100-6	2005	By comparison to our earlier results on the Li1-xNi0.5Mn0.5O2 system, we attribute the active participation of oxygen in the redox process in Li1-xCo1/3Ni1/3Mn1/3O2 to be related to the presence of Co in this system.	Oxygen	111-117	transglutaminase 1	Homo sapiens	44-47
16332100-6	2005	By comparison to our earlier results on the Li1-xNi0.5Mn0.5O2 system, we attribute the active participation of oxygen in the redox process in Li1-xCo1/3Ni1/3Mn1/3O2 to be related to the presence of Co in this system.	Oxygen	111-117	transglutaminase 1	Homo sapiens	142-145
18535813-9	2008	In addition, CD133 expression has recently been shown to be modulated by oxygen levels.	Oxygen	73-79	prominin 1	Homo sapiens	13-18
17940877-7	2008	In neonatal rats, hypoxia induced expressional and functional changes in the NMDAR1 receptors of neuronal cells which is corrected by supplementation of glucose alone or glucose followed by oxygen during the resuscitation to prevent the glutamate related neuronal damage.	Oxygen	190-196	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	77-83
24265420-2	2014	Insights into mitochondrial functioning show that oxygen consumption is principally coupled with either energy conversion as ATP or as heat, depending on whether the ATP-synthase or the mitochondrial uncoupling protein 1 (UCP1) is driving respiration.	Oxygen	50-56	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	222-226
18474440-6	2008	Treatment with 1% O2 markedly increased the gene expression levels of iNOS and MMP-9, indicating that ras/myc SFME cells alter the expression levels of tumor-associated genes and possibly enhance their malignancy as cancer cells under inflammatory, infectious and hypoxic conditions.	Oxygen	18-20	matrix metallopeptidase 9	Mus musculus	79-84
16219933-8	2005	Plasma levels of galectin-1 were higher in tumor-bearing severe combined immunodeficiency (SCID) mice breathing 10% O2 compared with mice breathing room air.	Oxygen	116-118	lectin, galactose binding, soluble 1	Mus musculus	17-27
18506083-6	2008	Although the expression levels of the PPARgamma target genes involved in lipid metabolism, such as aP2 and stearoyl-CoA desaturase 1, were upregulated in the white adipose tissue of the S112A mice, the serum levels of free fatty acid, triglyceride, adiponectin and leptin, as well as the oxygen consumption, were comparable between the wild-type and S112A mice under the HFD condition.	Oxygen	288-294	peroxisome proliferator activated receptor gamma	Mus musculus	38-47
24265420-6	2014	When exposed to cold, mice deficient for UCP1 showed an increase of 20.2% in plasmatic reactive oxygen metabolites, 81.8% in muscular oxidized glutathione and 47.1% in muscular protein carbonyls.	Oxygen	96-102	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	41-45
18506083-6	2008	Although the expression levels of the PPARgamma target genes involved in lipid metabolism, such as aP2 and stearoyl-CoA desaturase 1, were upregulated in the white adipose tissue of the S112A mice, the serum levels of free fatty acid, triglyceride, adiponectin and leptin, as well as the oxygen consumption, were comparable between the wild-type and S112A mice under the HFD condition.	Oxygen	288-294	transcription factor AP-2, alpha	Mus musculus	99-102
16485861-2	2005	Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species.	Oxygen	157-163	superoxide dismutase 2	Homo sapiens	0-30
16485861-2	2005	Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species.	Oxygen	157-163	superoxide dismutase 2	Homo sapiens	32-37
23682865-3	2014	RECENT ADVANCES: The activity of BKCa channels is regulated by O2, carbon monoxide (CO), and hydrogen sulfide (H2S), suggesting that integration of these signals may be crucial to the physiological response of this tissue.	Oxygen	63-65	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	33-37
16344215-2	2005	The goal of management is to improve hypoxemia, improve bronchoconstriction, and decrease airway edema through the administration of continuous nebulized beta2 adrenergic agonist with intermittent anticholinergics, corticosteroids, and oxygen.	Oxygen	236-242	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-159
18636206-8	2008	A clear effect of the O2 concentration on CA-IX expression was visible in GaMG and U251 cell lines whereas U373 showed a less differentiated pattern.	Oxygen	22-24	carbonic anhydrase 9	Homo sapiens	42-47
23682865-4	2014	BKCa is colocalized with hemeoxygenase-2, an enzyme that generates CO in the presence of O2, and CO is a BKCa channel opener.	Oxygen	89-91	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	0-4
16287844-2	2005	We show that loss of the Cu,Zn-dependent superoxide dismutase, SOD1, or its copper chaperone, LYS7, confers oxygen-dependent sensitivity to replication arrest and DNA damage in Saccharomyces cerevisiae.	Oxygen	108-114	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	63-67
23682865-5	2014	Reduced CO during hypoxia results in channel closure, conferring a degree of O2 sensitivity to the BKCa channel.	Oxygen	77-79	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	99-103
16287844-2	2005	We show that loss of the Cu,Zn-dependent superoxide dismutase, SOD1, or its copper chaperone, LYS7, confers oxygen-dependent sensitivity to replication arrest and DNA damage in Saccharomyces cerevisiae.	Oxygen	108-114	copper chaperone CCS1	Saccharomyces cerevisiae S288C	94-98
18425507-5	2008	Blood-oxygen level dependent BOLD fMRI revealed significantly elevated bilateral activity in visual areas (V1, V2) when the gratings to be compared had an orthogonal orientation, compared to when they had the same orientation.	Oxygen	6-12	immunoglobulin kappa variable 1-5	Homo sapiens	107-113
23873717-11	2014	Because iron deficiency can induce tissue hypoxia, oxygen deprivation was tested as a regulator of FGF23, and was shown to stimulate FGF23 mRNA in vitro and serum C-terminal FGF23 in normal rats in vivo.	Oxygen	51-57	fibroblast growth factor 23	Rattus norvegicus	99-104
18388202-4	2008	In this study, we examine the NO(2)(-)-dependent NO production in yeast engineered to contain alternative isoforms, Va or Vb, of Cco subunit V. Previous studies have shown that these isoforms have differential effects on oxygen reduction by Cco, and that their genes (COX5a and COX5b, respectively) are inversely regulated by oxygen.	Oxygen	221-227	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	268-273
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	191-195
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	260-264
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	260-264
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	260-264
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	260-264
18292194-5	2008	When compared with cells cultured in standard conditions (FiO2 = 20%), exposure of primary human trophoblasts to low oxygen concentration (FiO2 = 8% or &lt;or= 1%) enhanced the expression of CTGF mRNA in a time-dependent manner, with a significant increase in CTGF levels after 16 h (2.7 +/- 0.7-fold; P &lt; 0.01), reaching a maximum of 10.9 +/- 3.2-fold at 72 h. Whereas exposure to hypoxia had no effect on cellular CTGF protein levels, secretion of CTGF to the medium was increased after 16 h in hypoxia and remained elevated through 72 h. The increase in cellular CTGF transcript levels and CTGF protein secretion was recapitulated by exposure of trophoblasts to agents that enhance the activity of hypoxia-inducible factor (HIF)1alpha, including cobalt chloride or the proline hydroxylase inhibitor dimethyloxaloylglycine, and attenuated using the HIF1alpha inhibitor 2-methoxyestradiol.	Oxygen	117-123	cellular communication network factor 2	Homo sapiens	260-264
18491992-5	2008	TSC increases the rate of oxygen diffusion between the erythrocytes and the tissues by altering the "structure" of water in blood plasma.	Oxygen	26-32	solute carrier family 12 member 3	Homo sapiens	0-3
18359290-6	2008	Dose-dependent prosurvival effects of rapamycin were consistent with mTOR inhibition being a critical downstream mediator of AMPK in persistent low oxygen.	Oxygen	148-154	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	125-129
18364358-2	2008	The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate.	Oxygen	144-152	myo-inositol oxygenase	Homo sapiens	74-96
18326824-8	2008	In addition, we demonstrated that nitric oxide derived from nNOS is involved in a neurogenic mechanism of HBO2-induced lung injury that is linked to central nervous system oxygen toxicity through adrenergic/cholinergic pathways.	Oxygen	172-178	nitric oxide synthase 1, neuronal	Mus musculus	60-64
18375259-3	2008	With the supply of molecular oxygen upon reperfusion of ischemic tissues, xanthine oxidoreductase (XOR) metabolizes xanthine and hypoxanthine to uric acid and free radicals are generated.	Oxygen	29-35	xanthine dehydrogenase	Rattus norvegicus	74-97
18375259-3	2008	With the supply of molecular oxygen upon reperfusion of ischemic tissues, xanthine oxidoreductase (XOR) metabolizes xanthine and hypoxanthine to uric acid and free radicals are generated.	Oxygen	29-35	xanthine dehydrogenase	Rattus norvegicus	99-102
18388110-8	2008	Even in the presence of linear electron transport [11 mumol O2 (mg Chl)(-1) h(-1)], PGR5-dependent PSI electron transport was detected as a difference in Chl fluorescence levels in ruptured chloroplasts.	Oxygen	60-62	proton gradient regulation 5	Arabidopsis thaliana	84-88
17999717-6	2008	Our results demonstrate a clear difference in free radical production and oxygen consumption by mitochondrial Complex I between PrP-null mice and wild-type controls, pointing to Complex I as a potential target for pathological change, suggesting similarities between prion-related and other neurodegenerative diseases.	Oxygen	74-80	prion protein	Mus musculus	128-131
17350772-12	2008	However, the relative abundance of transcripts for Mn-SOD gene was greater (P&lt;0.05) for embryos cultured in high O2 tension system.	Oxygen	116-118	superoxide dismutase [Mn], mitochondrial	Bos taurus	51-57
18072750-5	2008	Here, we analyze the interference between the AhR signaling, activated by 10 nM 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), and the HIF-1 alpha pathway, induced by hypoxia (5% O2), in two human cell lines, the breast carcinoma cell line MCF-7 and the hepatocyte cell line HepG2.	Oxygen	177-179	aryl hydrocarbon receptor	Homo sapiens	46-49
18052254-0	2008	Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.	Oxygen	0-6	nitric oxide synthase 1	Homo sapiens	44-48
18052254-1	2008	Fully coupled nitric oxide synthase (NOS) catalyzes formation of nitric oxide (NO), l-citrulline, NADP+, and water from l-arginine, NADPH, and oxygen.	Oxygen	143-149	nitric oxide synthase 1	Homo sapiens	14-35
18290308-1	2008	The International Society on Oxygen Transport to Tissue (ISOTT) was founded in April, 1973 by Drs.	Oxygen	29-35	sushi repeat containing protein X-linked	Homo sapiens	94-97
18497086-4	2008	PEDF expression occurs in two HCC cell lines and is oxygen dependent.	Oxygen	52-58	serpin family F member 1	Homo sapiens	0-4
17934262-6	2008	Plasma BNP was weakly, negatively correlated to maximum exercise capability, peak oxygen uptake, maximum heart rate during exercise testing and minimal heart rate in the 24-hour Holter monitoring.	Oxygen	82-88	natriuretic peptide B	Homo sapiens	7-10
19025590-8	2008	Ang-2 correlated with partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2), tissue hypoxia, Sequential Organ Failure Assessment (SOFA) and Physiology and Chronic Health Evaluation II (APACHE II) score.	Oxygen	42-48	angiopoietin 2	Homo sapiens	0-5
19025590-8	2008	Ang-2 correlated with partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2), tissue hypoxia, Sequential Organ Failure Assessment (SOFA) and Physiology and Chronic Health Evaluation II (APACHE II) score.	Oxygen	95-101	angiopoietin 2	Homo sapiens	0-5
17967880-0	2008	Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.	Oxygen	97-103	von Hippel-Lindau tumor suppressor	Homo sapiens	84-87
17967880-7	2008	Disease-causing mutations of key residues of TD-NEM restrain the ability of VHL to efficiently mediate oxygen-dependent degradation of HIF by altering its nuclear export dynamics without affecting interaction with its substrate.	Oxygen	103-109	von Hippel-Lindau tumor suppressor	Homo sapiens	76-79
17627102-9	2008	While COPD patients increased their minute ventilation (13.47 +/- 2.73 to 14.88 +/- 2.67 l/min), non-COPD patients decreased their oxygen uptake from 6.27 +/- 1.61 to 5.54 +/- 1.35 ml/kg.	Oxygen	131-137	COPD	Homo sapiens	101-105
17977646-0	2007	Influence of oxygen tension on CD133 phenotype in human glioma cell cultures.	Oxygen	13-19	prominin 1	Homo sapiens	31-36
17977646-2	2007	We demonstrate, using low-passaged human tumor cell cultures established from glioma, that a reduction in the oxygen level in these cell cultures dramatically increases the percentage of CD133 expressing cells.	Oxygen	110-116	prominin 1	Homo sapiens	187-192
18155002-0	2007	Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.	Oxygen	32-38	G protein subunit alpha 12	Rattus norvegicus	104-115
17923475-3	2007	Mice null for iPLA(2)gamma display multiple bioenergetic dysfunctional phenotypes, including 1) growth retardation, 2) cold intolerance, 3) reduced exercise endurance, 4) greatly increased mortality from cardiac stress after transverse aortic constriction, 5) abnormal mitochondrial function with a 65% decrease in ascorbate-induced Complex IV-mediated oxygen consumption, and 6) a reduction in myocardial cardiolipin content accompanied by an altered cardiolipin molecular species composition.	Oxygen	353-359	patatin-like phospholipase domain containing 8	Mus musculus	14-26
17989798-0	2007	Oxygen-17 hyperfine structures in the pure rotational spectra of SrO, SnO, BaO, HfO and ThO.	Oxygen	0-6	stomatin like 3	Homo sapiens	65-68
17989798-0	2007	Oxygen-17 hyperfine structures in the pure rotational spectra of SrO, SnO, BaO, HfO and ThO.	Oxygen	0-6	strawberry notch homolog 1	Homo sapiens	70-73
17875644-3	2007	In aerobic cells, O(2)-dependent prolyl hydroxylation of HIF-1alpha is required for binding of the von Hippel-Lindau tumor suppressor protein VHL, which then recruits the Elongin C ubiquitin-ligase complex.	Oxygen	18-22	von Hippel-Lindau tumor suppressor	Homo sapiens	142-145
16311911-1	2005	Treatment of bovine pulmonary artery smooth muscle with the O2 *- generating system hypoxanthine plus xanthine oxidase stimulated MMP-2 activity and PKC activity; and inhibited Na+ dependent Ca2+ uptake in the microsomes.	Oxygen	60-62	matrix metallopeptidase 2	Bos taurus	130-135
16216223-6	2005	The altered cellular redox state arising from increased GSH may perturb oxygen-sensing mechanisms in hypoxic Mtf1 KO cells and decrease the accumulation of HIF-1alpha protein.	Oxygen	72-78	metal regulatory transcription factor 1	Homo sapiens	109-113
16285745-1	2005	Chemotaxis signal transducer protein DcrA from a sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough was previously shown to contain a c-type heme in its periplasmic domain (DcrA-N) for sensing redox and/or oxygen [Fu et al.	Oxygen	219-225	dcrA	Desulfovibrio vulgaris str. Hildenborough	37-41
16285745-1	2005	Chemotaxis signal transducer protein DcrA from a sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough was previously shown to contain a c-type heme in its periplasmic domain (DcrA-N) for sensing redox and/or oxygen [Fu et al.	Oxygen	219-225	dcrA	Desulfovibrio vulgaris str. Hildenborough	186-190
16285745-7	2005	Reaction of the reduced DcrA-N with molecular oxygen results in autoxidation to form a ferric state without forming any stable oxygen-bound form probably due to the extremely low redox potential of DcrA-N (-250 mV).	Oxygen	46-52	dcrA	Desulfovibrio vulgaris str. Hildenborough	24-28
16285745-7	2005	Reaction of the reduced DcrA-N with molecular oxygen results in autoxidation to form a ferric state without forming any stable oxygen-bound form probably due to the extremely low redox potential of DcrA-N (-250 mV).	Oxygen	46-52	dcrA	Desulfovibrio vulgaris str. Hildenborough	198-202
16285745-7	2005	Reaction of the reduced DcrA-N with molecular oxygen results in autoxidation to form a ferric state without forming any stable oxygen-bound form probably due to the extremely low redox potential of DcrA-N (-250 mV).	Oxygen	127-133	dcrA	Desulfovibrio vulgaris str. Hildenborough	24-28
16285745-9	2005	that DcrA would act as a redox and/or oxygen sensor, in which the ligand exchange between water and an endogenous amino acid is a trigger for signal transduction.	Oxygen	38-44	dcrA	Desulfovibrio vulgaris str. Hildenborough	5-9
16291649-5	2005	We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions.	Oxygen	111-117	arginine deiminase	Escherichia coli	168-172
16358018-0	2005	Mechanism of HCS + O2 reaction: hydrogen- or oxygen-transfer?	Oxygen	45-51	holocarboxylase synthetase	Homo sapiens	13-16
16358018-3	2005	It is shown that the most feasible pathway is the O2 addition to the HCS radical forming the intermediate SC(H)OO which can undergo a subsequent O-extrusion leading to SC(H)O + 3O.	Oxygen	50-52	holocarboxylase synthetase	Homo sapiens	69-72
15849232-3	2005	Using l-lysine, the preferred amino acid transported by CAT-1, we competitively inhibited extracellular l-arginine transport into endothelial cells during conditions of NaCl hyperosmolarity, low oxygen, and flow increase.	Oxygen	195-201	solute carrier family 7 member 1	Rattus norvegicus	56-61
15994466-5	2005	MEASUREMENTS AND MAIN RESULTS: The 60% oxygen-mediated lung injury was associated with increased lung mRNAs for hepatocyte growth factor and c-Met, relative to air-exposed control lungs, at Day 7 after birth.	Oxygen	39-45	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	141-146
15994466-6	2005	After exposure to 60% oxygen, immunoreactive HGF was increased at Days 4 and 7, and immunoreactive c-Met was increased at Day 14.	Oxygen	22-28	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	99-104
15994466-9	2005	CONCLUSIONS: HGF and its c-Met receptor are required for normal postnatal alveolar formation from secondary crests, and are upregulated during 60% oxygen-induced neonatal lung injury.	Oxygen	147-153	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	25-30
16135775-4	2005	This induction is further enhanced by constantly reducing the O(2) concentration to 1% O(2), and is accompanied by increased sPLA(2) activity.	Oxygen	62-66	phospholipase A2 group IIA	Rattus norvegicus	125-132
16135775-4	2005	This induction is further enhanced by constantly reducing the O(2) concentration to 1% O(2), and is accompanied by increased sPLA(2) activity.	Oxygen	87-91	phospholipase A2 group IIA	Rattus norvegicus	125-132
15994299-0	2005	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.	Oxygen	115-121	NADPH oxidase 1	Homo sapiens	81-85
16094474-3	2005	X-Ray structure analysis of L-2 reveals that one of the two amino acids is bound to the metal centre in a bidentate fashion while the other amino acid is bound as a zwitterion via the carboxylate oxygen only.	Oxygen	196-202	immunoglobulin kappa variable 3-15	Homo sapiens	28-31
16222887-7	2005	BNP levels correlated with PAP (r = 0.68), partial arterial oxygen pressure (r = -0.70), FEV1 (r = -0.65) and FVC (r = -0.52).	Oxygen	60-66	natriuretic peptide B	Homo sapiens	0-3
16045352-4	2005	In this article we are reporting static and dynamic aspects of the enzyme catalysis in a bimolecular reaction, namely a methyl transfer from S-adenosylmethionine to the hydroxylate oxygen of a substituted catechol catalyzed by catechol O-methyltransferase.	Oxygen	181-187	catechol-O-methyltransferase	Homo sapiens	227-255
16079649-8	2005	Cytochrome c oxidase (COX) activity was quantified electrochemically using the Clark oxygen electrode.	Oxygen	85-91	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
16298938-8	2005	In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways (ERK and Akt) and resulted in increased survival of irradiated cells in vitro.	Oxygen	86-92	superoxide dismutase 2	Homo sapiens	128-133
15799019-6	2005	Furthermore, we demonstrated that overexpressed RTN3 and stimuli that activate both EOR and UPR, not UPR only, were able to induce up-regulation of inducible nitric oxide synthase (iNOS) in HeLa cells through ER Ca(2+) release and reactive oxygen intermediates (ROIs), resulting in endogenous calcium-dependent nitric oxide protecting cells against ER specific apoptosis, which suggested that the nitric oxide and iNOS represented a likely protective response to EOR, not the UPR.	Oxygen	240-246	reticulon 3	Homo sapiens	48-52
15916908-6	2005	This review will give a broad overview of known CSN5 and COP9 Signalosome functions and how these functions impact the pVHL/HIF-1alpha signaling complex and potentially other oxygen-sensitive response networks.	Oxygen	175-181	von Hippel-Lindau tumor suppressor	Homo sapiens	119-123
16191268-23	2005	The level and ratio of caspase-3 gene expression were very low or absent in the lungs of neonatal rats exposed to 95% O(2) or room air.	Oxygen	118-122	caspase 3	Rattus norvegicus	23-32
15998134-2	2005	In this study, LOXs 2 and 3 were purified and used to generate hydroperoxide (HPOD) products in an in vitro system using linoleic acid as a substrate in the presence of either air or O2.	Oxygen	183-185	seed linoleate 9S-lipoxygenase-2	Glycine max	15-27
16084160-10	2005	By multivariate analysis, a baseline HGF concentration &gt;802 pg/mL was associated with an increased cardiovascular mortality (hazard ratio = 1.85, 95% CI 1.09-3.13, P = .02); other variables retained into the final model were B-type natriuretic peptide (P &lt; .0001), peak oxygen consumption (P = .0002), and ischemic etiology (P = .0005).	Oxygen	276-282	hepatocyte growth factor	Homo sapiens	37-40
17998805-2	2007	These mutations invariably result in an inappropriate accumulation of HIF-alpha due to a failure of VHL as a substrate-recognition component of an E3 ubiquitin ligase complex to target HIFalpha for oxygen-dependent ubiquitin-mediated destruction.	Oxygen	198-204	von Hippel-Lindau tumor suppressor	Homo sapiens	100-103
18056037-4	2007	Prolonged hypoxia (5% O2 for 5-6 days) also induced the expression of calcitonin receptor at high levels, and those of cathepsin K, and tartarate-resistant alkaline phosphatase (TRAP) at low-moderate levels in macrophage cells.	Oxygen	22-24	cathepsin K	Mus musculus	119-130
17849083-3	2007	A central role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element (IRE)/iron regulatory protein (IRP) system.	Oxygen	34-40	Wnt family member 2	Homo sapiens	167-170
17900539-8	2007	The results indicate that TCAP may play a neuroprotective role during periods of pH stress by upregulating oxygen radical scavenging systems.	Oxygen	107-113	titin-cap	Mus musculus	26-30
23873717-11	2014	Because iron deficiency can induce tissue hypoxia, oxygen deprivation was tested as a regulator of FGF23, and was shown to stimulate FGF23 mRNA in vitro and serum C-terminal FGF23 in normal rats in vivo.	Oxygen	51-57	fibroblast growth factor 23	Rattus norvegicus	133-138
23873717-11	2014	Because iron deficiency can induce tissue hypoxia, oxygen deprivation was tested as a regulator of FGF23, and was shown to stimulate FGF23 mRNA in vitro and serum C-terminal FGF23 in normal rats in vivo.	Oxygen	51-57	fibroblast growth factor 23	Rattus norvegicus	133-138
17850092-1	2007	Regio- and stereoselective aziridine ring opening with oxygen nucleophiles derived from serine and threonine provides a route to stereochemically pure 4-oxa-2,6-diaminopimelic acid (oxa-DAP) and its methyl-substituted derivatives.	Oxygen	55-61	death associated protein	Homo sapiens	186-189
24103013-7	2014	In addition, high oxygen tension during in vitro culture (IVC) with RDCM significantly increases the mRNA expression of oxidative stress-related genes (GPX-1, SOD-1, CAT and GSS) (P &lt; 0.05).	Oxygen	18-24	superoxide dismutase [Cu-Zn]	Bos taurus	159-164
17556672-0	2007	Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.	Oxygen	12-18	eukaryotic translation initiation factor 4E	Homo sapiens	30-35
17556672-5	2007	Conversely, FDLE cultured at 21% O(2) expressed lower levels of 4E-BP and maintained eIF4E-eIF4G association independent of DEX.	Oxygen	33-37	eukaryotic translation initiation factor 4E	Homo sapiens	85-90
24383499-11	2014	The results confirm the absence of americium(III) chloride complexes at T = 25 and 90  C ([Am(III)] = 10(-3) m, [Cl(-)] = 3.0 m), and the spectra are described by 9-10 oxygen atoms at a distance of 2.44-2.48 A.	Oxygen	168-174	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-1
17556672-7	2007	Under 3% O(2), DEX decreased abundance of phosphorylated forms of the mTOR effectors, S6 kinase and ribosomal protein S6.	Oxygen	9-13	ribosomal protein S6	Homo sapiens	100-120
17881913-3	2007	We have shown that a mutation in a subunit, cytochrome b large subunit (SDHC), of complex II, also results in increasing O2 production and therefore leads to apoptosis and precocious aging in Caenorhabditis elegans.	Oxygen	121-123	cytochrome b	Caenorhabditis elegans	44-56
24563849-4	2014	The exposure of C57BL/6 mice to &gt;=99% O2 (hyperoxia) significantly increased the accumulation of HMGB1 in the bronchoalveolar lavage fluids (BALF) prior to the onset of severe inflammatory lung injury.	Oxygen	41-43	high mobility group box 1	Mus musculus	100-105
24331390-2	2014	OBJECTIVE: To perform a systematic review with a meta-analysis of randomized trials designed to evaluate the efficacy of heliox versus oxygen in driving beta2-agonist nebulization in patients with acute asthma.	Oxygen	135-141	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	153-158
17513561-8	2007	Treatment of mice with a peptide containing a alpha(v)beta3/alpha(v)beta5-integrin targeting domain fused to a proapoptotic domain significantly reduced oxygen-induced retinal angiogenesis by selectively inducing activated endothelial cell apoptosis.	Oxygen	153-159	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	54-73
17698846-8	2007	These results reveal different mechanisms for oxygen metabolism for eNOS as opposed to nNOS and, perhaps, partially explain their functional differences.	Oxygen	46-52	nitric oxide synthase 1	Homo sapiens	87-91
17604179-9	2007	The quantum yield of oxygen uptake Phi(-O2) as a measure of formation of hydrogen peroxide increases with increasing amino acid concentration, approaching Phi(-O2) for AQ in air-saturated solution.	Oxygen	21-27	glucose-6-phosphate isomerase	Homo sapiens	35-38
24178804-7	2014	Induced pellets cultured in 5% O2 had increased control-adjusted gene expression of aggrecan, SOX9 and collagen I and decreased collagen X compared with 21% O2 cultures.	Oxygen	31-33	SRY-box transcription factor 9	Homo sapiens	94-98
17604179-9	2007	The quantum yield of oxygen uptake Phi(-O2) as a measure of formation of hydrogen peroxide increases with increasing amino acid concentration, approaching Phi(-O2) for AQ in air-saturated solution.	Oxygen	21-27	glucose-6-phosphate isomerase	Homo sapiens	155-158
24503888-0	2014	Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.	Oxygen	29-35	amine oxidase copper containing 3	Homo sapiens	15-19
17697940-5	2007	Together, these data indicate that PrPC has a critical role to play in protecting cells against reactive-oxygen-species-mediated DNA damage; a function which requires the octapeptide repeats in the protein, is lost in disease-associated mutants of the protein or upon conversion to PrPSc, and thus provide further support for the neuroprotective role for PrPC.	Oxygen	105-111	prion protein	Mus musculus	35-39
24503888-0	2014	Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.	Oxygen	29-35	amine oxidase copper containing 3	Homo sapiens	20-25
25427248-4	2014	Further, by using a two-electrode setup equipped with a reference electrode, we could demonstrate that, at 1.6 V, the positive electrode potential reaches a value of 0.96 V vs. NHE in 1 mol L(-1) Li2SO4, crossing the thermodynamic potential limit of oxygen evolution (Eox = 0.846 V vs. NHE), and the pitting potential, Epit = 0.95 V vs. NHE.	Oxygen	250-256	solute carrier family 9 member C1	Homo sapiens	177-180
17182129-1	2007	BACKGROUND: In patients with chronic heart failure (CHF), B-type natriuretic peptide (BNP) is related to peak oxygen consumption (peak VO2) and the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope).	Oxygen	110-116	natriuretic peptide B	Homo sapiens	58-84
17182129-1	2007	BACKGROUND: In patients with chronic heart failure (CHF), B-type natriuretic peptide (BNP) is related to peak oxygen consumption (peak VO2) and the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope).	Oxygen	110-116	natriuretic peptide B	Homo sapiens	86-89
25427248-4	2014	Further, by using a two-electrode setup equipped with a reference electrode, we could demonstrate that, at 1.6 V, the positive electrode potential reaches a value of 0.96 V vs. NHE in 1 mol L(-1) Li2SO4, crossing the thermodynamic potential limit of oxygen evolution (Eox = 0.846 V vs. NHE), and the pitting potential, Epit = 0.95 V vs. NHE.	Oxygen	250-256	solute carrier family 9 member C1	Homo sapiens	286-289
16042900-0	2005	[Effects of hyperbaric oxygen with free-radical antagonists on the expression and activity of matrix metalloproteinase-2 in rat livers].	Oxygen	23-29	matrix metallopeptidase 2	Rattus norvegicus	94-120
25427248-4	2014	Further, by using a two-electrode setup equipped with a reference electrode, we could demonstrate that, at 1.6 V, the positive electrode potential reaches a value of 0.96 V vs. NHE in 1 mol L(-1) Li2SO4, crossing the thermodynamic potential limit of oxygen evolution (Eox = 0.846 V vs. NHE), and the pitting potential, Epit = 0.95 V vs. NHE.	Oxygen	250-256	solute carrier family 9 member C1	Homo sapiens	286-289
17853348-10	2007	CONCLUSION: During nasal oxygen administration the severity of dyspnoea, as measured by use of NRS had not decreased, whereas it had significantly decreased after the first opioid administration.	Oxygen	25-31	sphingolipid transporter 1 (putative)	Homo sapiens	95-98
25298778-4	2014	VHL inactivation by genetic mechanisms, such as mutation and loss of heterozygosity, inhibits HIF1A degradation, even in the presence of oxygen, and induces a pseudohypoxic response.	Oxygen	137-143	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
17545940-2	2007	The mechanism of action proposed for TSC is that it increases the diffusion of oxygen through blood plasma and into the tissue.	Oxygen	79-85	solute carrier family 12 member 3	Rattus norvegicus	37-40
15978025-6	2005	The results demonstrate activation of specific brain areas during execution of the brain regulation skill allowing a person to activate an external device; a successful positive SCP shift compared with a negative shift was closely related to an increase of the blood oxygen level-dependent response in the basal ganglia.	Oxygen	267-273	urocortin 3	Homo sapiens	178-181
23484525-5	2014	We also examined whether exposing placental explants to hypoxia (1% oxygen) changed the expression of PAPPA2.	Oxygen	68-74	pappalysin 2	Homo sapiens	102-108
15857155-4	2005	Here we report experiments with wild-type and adenosine A2AR-deficient mice that confirm the predicted effects of oxygen.	Oxygen	114-120	adenosine A2a receptor	Mus musculus	56-60
17585072-6	2007	Comparing mice maintained for 21 days under hypoxic (10% O(2)) or normoxic (21% O(2)) conditions, an upregulation exclusively of NOX4 mRNA was observed under hypoxia in homogenized lung tissue, concomitant with increased levels in microdissected pulmonary arterial vessels.	Oxygen	57-61	NADPH oxidase 4	Mus musculus	129-133
17585072-6	2007	Comparing mice maintained for 21 days under hypoxic (10% O(2)) or normoxic (21% O(2)) conditions, an upregulation exclusively of NOX4 mRNA was observed under hypoxia in homogenized lung tissue, concomitant with increased levels in microdissected pulmonary arterial vessels.	Oxygen	80-84	NADPH oxidase 4	Mus musculus	129-133
24141691-4	2013	The O2-sensitive phosphorescence of Ru(dpp)3 was used as a transduction mechanism and catalase was used as a biocomponent for sensing.	Oxygen	4-6	dipeptidyl peptidase 3	Homo sapiens	36-44
17646880-6	2007	Electrochemical charge transfer processes in the pre-oxide/oxide anodic region with adsorbed oxygen and hydroxide, involving a change in Au redox state (Au(0)/Au(+)) were visible in the SPR, due to a change in the gold layer thickness and gold oxide layer.	Oxygen	93-99	sepiapterin reductase	Homo sapiens	186-189
17394531-5	2007	Additionally, we tested the hypothesis that mutant SOD1 increases mitochondrial-produced superoxide (O(2) (*)) levels and that SOD2 overexpression protects neurons from mutant SOD1-induced toxicity by reducing O(2) (*) levels in mitochondria.	Oxygen	210-214	superoxide dismutase 2	Homo sapiens	127-131
15888840-8	2005	RESULTS: In PPH patients, the percentage of predicted peak oxygen uptake (Vo(2)) correlated significantly with mean pulmonary artery pressure (mPAP) [r = - 0.59, p = 0.0007, n = 29].	Oxygen	59-65	phospholipid phosphatase 1	Mus musculus	143-147
15826842-6	2005	Breathing oxygen during induced anemia resulted in a P300 latency not different from that at baseline when breathing air (P = 0.5) or oxygen (P = 0.8).	Oxygen	10-16	E1A binding protein p300	Homo sapiens	53-57
15853801-7	2005	In addition, an in vitro reconstitution experiment using recombinant PsbOs and urea-washed PSII particles showed that oxygen evolution was better recoVERed by PsbO1 than by PsbO2.	Oxygen	118-124	photosystem II subunit O-2	Arabidopsis thaliana	173-178
15850923-7	2005	At 1-log cell kill, the +/+ ras/TAg and -/- ras/TAg cells had an identical oxygen enhancement ratio of 1.28 +/- 0.09 and nearly identical oxygen enhancement ratios at 2-log cell kill.	Oxygen	75-81	temporal alpha-galactosidase	Mus musculus	32-35
17394531-8	2007	These elevated O(2) (*) levels in mitochondria were significantly diminished by the overexpression of SOD2.	Oxygen	15-19	superoxide dismutase 2	Homo sapiens	102-106
24316858-10	2013	The genes that were up regulated in the oxygen carriers cluster (12 genes) were: Hbq1, Mb, Ngb, Slc38a1 and Xirp1.	Oxygen	40-46	neuroglobin	Mus musculus	91-94
15657899-1	2005	Neuroglobin (Ngb), a recently discovered intracellular respiratory globin in neurons, may play a crucial role in oxygen homeostasis in the brain.	Oxygen	113-119	neuroglobin	Mus musculus	0-11
15657899-1	2005	Neuroglobin (Ngb), a recently discovered intracellular respiratory globin in neurons, may play a crucial role in oxygen homeostasis in the brain.	Oxygen	113-119	neuroglobin	Mus musculus	13-16
15657899-5	2005	The discovery of Ngb in astrocytes may provide some insight into how oxygen homeostasis is regulated in the brain.	Oxygen	69-75	neuroglobin	Mus musculus	17-20
24316858-10	2013	The genes that were up regulated in the oxygen carriers cluster (12 genes) were: Hbq1, Mb, Ngb, Slc38a1 and Xirp1.	Oxygen	40-46	solute carrier family 38, member 1	Mus musculus	96-103
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Oxygen	245-251	delta-6 fatty acyl desaturase	Salmo salar	172-178
16020260-0	2005	Increased expression of chemokine KC, an interleukin-8 homologue, in a model of oxygen-induced retinopathy.	Oxygen	80-86	chemokine (C-X-C motif) ligand 15	Mus musculus	41-54
24061560-1	2013	Copper-zinc superoxide dismutase (Sod1) is an abundant intracellular enzyme that catalyzes the disproportionation of superoxide to give hydrogen peroxide and dioxygen.	Oxygen	158-166	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	34-38
24319338-1	2013	Part B: GSK-3beta and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen.	Oxygen	115-121	glycogen synthase kinase 3 beta	Homo sapiens	8-17
15763464-2	2005	Catalase is one of the regulatory enzymes and facilitates the degradation of hydrogen peroxide to oxygen and water.	Oxygen	98-104	catalase	Bombyx mori	0-8
23735260-3	2013	We trained a supervised classifier (multi-layer perceptron; MLP) to associate blood oxygen level dependent (BOLD) correlation maps corresponding to pre-defined seeds with specific RSN identities.	Oxygen	84-90	cysteine and glycine rich protein 3	Homo sapiens	60-63
15798192-4	2005	This adaptive mechanism is accompanied by initial inhibition of the myoD, E2A, and myogenin genes followed by resumption of their expression in an oxygen-dependent manner.	Oxygen	147-153	transcription factor 3	Homo sapiens	74-91
15743827-6	2005	This was paralleled by a 2.7- +/- 0.5-fold increase in p47phox-TRAF4 association, membrane translocation of p47phox-TRAF4, a 2.3- +/- 0.4-fold increase in p47phox-p22phox complex formation, and a 3.2- +/- 0.2-fold increase in NADPH-dependent O2- production (all P &lt; 0.05).	Oxygen	242-244	TNF receptor associated factor 4	Homo sapiens	63-68
15743827-7	2005	TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron.	Oxygen	175-177	TNF receptor associated factor 4	Homo sapiens	0-5
24229686-0	2013	Cbl-b and PI3K/Akt pathway are differently involved in oxygen-glucose deprivation preconditioning in PC12 cells.	Oxygen	55-61	Cbl proto-oncogene B	Rattus norvegicus	0-5
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Oxygen	271-273	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	70-90
15637297-0	2005	A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase.	Oxygen	136-142	nitric oxide synthase 1, neuronal	Mus musculus	12-42
15637297-10	2005	There was an increase in lucigenin-detectable superoxide anion (O2-) in cardiac tissues from nNOS-/- compared with WT.	Oxygen	64-66	nitric oxide synthase 1, neuronal	Mus musculus	93-97
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Oxygen	271-273	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	92-95
23996000-4	2013	For elucidation of the structural bases for the mechanism of the proton collection and timely closure of the water channel, conformational dynamics after photolysis of CO (an O2 analog)-bound CcO was examined using a newly developed time-resolved infrared system feasible for accurate detection of a single C=O stretch band of alpha-helices of CcO in H2O medium.	Oxygen	175-177	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	192-195
15683236-10	2005	An interpretation is proposed to explain this difference between GOX on one hand and FCB2 and LCHAO on the other hand, which had been proposed to arise from the differences between family members in their reactivity with oxygen.	Oxygen	221-227	L-lactate dehydrogenase (cytochrome)	Saccharomyces cerevisiae S288C	85-89
24135936-0	2013	Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondria and inhibition of AIF and cytochrome c release.	Oxygen	27-33	RB transcriptional corepressor 1	Homo sapiens	12-15
24032351-4	2013	The procyanidins produced a concentration-dependent relaxation in endothelium-intact vascular rings by activation of the NO and endothelium-derived hyperpolarizing factor (EDHF)-signaling pathway via PI3/Akt kinase in a redox-sensitive manner, with O2(-) as key species predominantly produced by xanthine oxidase and NADPH oxidase.	Oxygen	249-251	peptidase inhibitor 3	Homo sapiens	200-203
15965718-0	2005	Dissolved oxygen saturation controls PAH biodegradation in freshwater estuary sediments.	Oxygen	10-16	phenylalanine hydroxylase	Homo sapiens	37-40
15674875-3	2005	Acute exacerbations of COPD, usually related to superimposed infection occur commonly and systemic corticosteroids are widely used in their management in combination with other treatments including antibiotics, oxygen supplementation and bronchodilators.	Oxygen	211-217	COPD	Homo sapiens	23-27
23668615-3	2013	The exposure of HPASMCs to hypoxia (3% O2) increased AMPK activation and phosphorylation, and the inhibition of AMPK with Compound C during hypoxia decreased their viability and increased lactate dehydrogenase activity and apoptosis.	Oxygen	39-41	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	53-57
23775935-0	2013	The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice.	Oxygen	12-18	thrombospondin 2	Mus musculus	78-82
16594161-3	2005	It is also possible to use spatially resolved spectroscopy to measure absolute mean cerebral oxygen saturation (SmcO2).	Oxygen	93-99	single-pass membrane protein with coiled-coil domains 2	Homo sapiens	112-117
15745143-10	2005	After protamine infusion, total body oxygen delivery and consumption correlated negatively with S100beta levels (both p &lt; 0.05) and with NAG levels (both p &lt; 0.01).	Oxygen	37-43	O-GlcNAcase	Homo sapiens	140-143
15789657-3	2005	Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species.	Oxygen	242-248	glial cell derived neurotrophic factor	Rattus norvegicus	17-21
16869749-0	2005	The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.	Oxygen	68-74	von Hippel-Lindau tumor suppressor	Homo sapiens	4-38
23775935-4	2013	The proposed mechanism for this shift in MSC fate is that increased vascular density and hence oxygen availability in TSP2-null mice regulates differentiation.	Oxygen	95-101	thrombospondin 2	Mus musculus	118-122
16869749-4	2005	The best understood function of pVHL relates to its role as the substrate recognition unit of an E3 ligase that targets the heterodimeric transcription factor HIF (hypoxia-inducible factor) for destruction in the presence of oxygen.	Oxygen	225-231	von Hippel-Lindau tumor suppressor	Homo sapiens	32-36
23775935-6	2013	The objective of this study is to use a previously developed computational model of tissue differentiation, in which substrate stiffness and oxygen tension regulate stem cell differentiation, to simulate potential mechanisms which may drive alterations in MSC fate in TSP2-null mice.	Oxygen	141-147	thrombospondin 2	Mus musculus	268-272
24040138-10	2013	In conclusions, ATM (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest and allowed time to facilitate sperm-derived DNA-damage repair in mouse zygotes fertilized with oxygen-stressed sperm, and the DNA-damage repair might be effective.	Oxygen	195-201	ataxia telangiectasia mutated	Mus musculus	16-19
15498885-4	2005	The purpose of this study was to determine whether tissue hypoxygenation [induced by lack of oxygen] or inhalation of carbon monoxide (CO) are sufficient to up-regulate leptin in fat cells as well as in peripheral organs such as lung, liver, and kidney of rats.	Oxygen	61-67	leptin	Rattus norvegicus	169-175
23884424-8	2013	These analyses revealed that oxygen consumption of Ptpn11(E76K/+) cells and the respiratory function of Ptpn11(E76K/+) mitochondria were significantly increased.	Oxygen	29-35	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	51-57
24377245-7	2013	At the high dissolved oxygen level the CAT activity of E. coli JM109/pDXW-Ptkt-cat and C. crenatum SYPA5-5/pDXW-Ptkt-cat were 3.032 U/mg and 1.987 U/mg, which were 2.8-fold and 3.2-fold than that in the low dissolved oxygen, respectively.	Oxygen	22-28	chloramphenicol acetyltransferase	Escherichia coli	39-42
16255146-3	2005	High-level transcription required both ArcA and Fnr systems to be functional; low oxygen induction required at least one of ArcA and Fnr to be intact.	Oxygen	82-88	arginine deiminase	Escherichia coli	124-128
24377245-7	2013	At the high dissolved oxygen level the CAT activity of E. coli JM109/pDXW-Ptkt-cat and C. crenatum SYPA5-5/pDXW-Ptkt-cat were 3.032 U/mg and 1.987 U/mg, which were 2.8-fold and 3.2-fold than that in the low dissolved oxygen, respectively.	Oxygen	22-28	chloramphenicol acetyltransferase	Escherichia coli	79-82
24377245-7	2013	At the high dissolved oxygen level the CAT activity of E. coli JM109/pDXW-Ptkt-cat and C. crenatum SYPA5-5/pDXW-Ptkt-cat were 3.032 U/mg and 1.987 U/mg, which were 2.8-fold and 3.2-fold than that in the low dissolved oxygen, respectively.	Oxygen	217-223	chloramphenicol acetyltransferase	Escherichia coli	39-42
24377245-7	2013	At the high dissolved oxygen level the CAT activity of E. coli JM109/pDXW-Ptkt-cat and C. crenatum SYPA5-5/pDXW-Ptkt-cat were 3.032 U/mg and 1.987 U/mg, which were 2.8-fold and 3.2-fold than that in the low dissolved oxygen, respectively.	Oxygen	217-223	chloramphenicol acetyltransferase	Escherichia coli	79-82
17329595-1	2007	Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated with small increases in the expression of glucose transporter 1 (SLC2A1), anaphase promoting complex (ANAPC1), and myotrophin (MTPN), suggesting a role for oxygen in the regulation of embryo development, mediated through oxygen-sensitive gene expression.	Oxygen	9-15	solute carrier family 2 member 1	Bos taurus	186-192
16111822-2	2005	We tested the ability of Bcl-xl overexpression to protect primary cultures of embryonic rat septal neurons subjected to one of four different stresses: 6 h of combined oxygen-glucose deprivation, which produces rapid cell death, or a 24 h exposure to hypoglycemia, hyperglycemia, or 1mM 3-nitropropionic acid (an inhibitor of mitochondrial respiration), which results in a more slowly-developing death.	Oxygen	168-174	Bcl2-like 1	Rattus norvegicus	25-31
23959881-4	2013	NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria.	Oxygen	110-116	max binding protein	Mus musculus	64-67
16111822-6	2005	This result indicates that Bcl-xl"s saving effects are not due solely to blocking delayed (apoptotic) death, because death following oxygen-glucose deprivation was rapid and was not accompanied by increased activation of caspase-3.	Oxygen	133-139	Bcl2-like 1	Rattus norvegicus	27-33
16344152-4	2005	The mitogen-activated protein kinases extracellular signal-regulated kinase 1 and extracellular signal-regulated kinase 2 were activated immediately after oxygen and glucose deprivation both in CA1 and in CA3/fascia dentata.	Oxygen	155-161	mitogen activated protein kinase 3	Rattus norvegicus	38-121
17329595-1	2007	Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated with small increases in the expression of glucose transporter 1 (SLC2A1), anaphase promoting complex (ANAPC1), and myotrophin (MTPN), suggesting a role for oxygen in the regulation of embryo development, mediated through oxygen-sensitive gene expression.	Oxygen	9-15	myotrophin	Bos taurus	236-246
17329595-1	2007	Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated with small increases in the expression of glucose transporter 1 (SLC2A1), anaphase promoting complex (ANAPC1), and myotrophin (MTPN), suggesting a role for oxygen in the regulation of embryo development, mediated through oxygen-sensitive gene expression.	Oxygen	9-15	myotrophin	Bos taurus	248-252
23959881-5	2013	Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy.	Oxygen	323-329	max binding protein	Mus musculus	50-53
17555402-1	2007	The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate for COX (cytochrome c oxidase), which constitutes Complex IV of the mitochondrial respiratory chain.	Oxygen	72-74	cytochrome c oxidase subunit 8A	Homo sapiens	94-97
23612353-1	2013	Neuroglobin (Ngb), a neuron-specific heme-binding protein that binds O2, CO and NO reversibly, and promotes in vivo and in vitro cell survival after hypoxic and ischaemic insult.	Oxygen	69-71	neuroglobin	Mus musculus	0-11
17555402-9	2007	COX subunit switching occurs in yeast, but by a completely different regulatory mechanism, suggesting that selection for O2-dependent homoeostatic regulation of mitochondrial respiration is ancient and likely to be shared by all eukaryotic organisms.	Oxygen	121-123	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
17521827-0	2007	Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase.	Oxygen	82-88	mitogen activated protein kinase 14	Rattus norvegicus	174-177
18050914-7	2007	The storage stability of the co-immobilized GOD-CAT was also found to be higher than that of the free form at both 5 degrees C and 25 degrees C. The increased GOD activity and reusability resulting from the co-immobilization process may have been due to CAT protecting GOD from inactivation by H2O2 and supplying additional O2 to the reaction system.	Oxygen	296-298	catalase	Bos taurus	48-51
17425347-1	2007	In this paper we present a study of using oxygen plasma for chemically modifying inert hydrocarbon self-assembled monolayers of octadecyltrichlorosilane (OTS-SAMs) and rendering active surfaces for protein immobilization.	Oxygen	42-48	methionine adenosyltransferase 1A	Homo sapiens	158-162
17425347-3	2007	Our XPS results showed that the surface reaction between OTS-SAMs and oxygen plasma can generate new surface functional groups such as alcohol (C-O), aldehyde (C=O), and carboxylic acid (O-C=O), and their compositions can be controlled by using different treatment times and powers.	Oxygen	70-76	methionine adenosyltransferase 1A	Homo sapiens	61-65
15707856-2	2005	TSC has been suggested to work by increasing the diffusion rate of oxygen through plasma rather than on a specific symptom of hemorrhagic shock and has been suggested as a general treatment for hypoxemia.	Oxygen	67-73	solute carrier family 12 member 3	Rattus norvegicus	0-3
15611513-2	2004	The VHL tumor suppressor protein (pVHL), through its oxygen-dependent polyubiquitylation of hypoxia-inducible factor (HIF), plays a central role in the mammalian oxygen-sensing pathway.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	34-38
15611513-2	2004	The VHL tumor suppressor protein (pVHL), through its oxygen-dependent polyubiquitylation of hypoxia-inducible factor (HIF), plays a central role in the mammalian oxygen-sensing pathway.	Oxygen	162-168	von Hippel-Lindau tumor suppressor	Homo sapiens	34-38
15611513-3	2004	This interaction between pVHL and HIF is governed by post-translational prolyl hydroxylation of HIF in the presence of oxygen by a conserved family of Egl-nine (EGLN) enzymes.	Oxygen	119-125	von Hippel-Lindau tumor suppressor	Homo sapiens	25-29
23612353-1	2013	Neuroglobin (Ngb), a neuron-specific heme-binding protein that binds O2, CO and NO reversibly, and promotes in vivo and in vitro cell survival after hypoxic and ischaemic insult.	Oxygen	69-71	neuroglobin	Mus musculus	13-16
15548613-1	2004	Neuroglobin (Ngb), a globular heme protein expressed in the brain of vertebrates, binds oxygen reversibly, with an affinity comparable to myoglobin (Mb).	Oxygen	88-94	neuroglobin	Mus musculus	0-11
17393536-3	2007	The expression levels of tuftelin mRNA were significantly higher in mouse kidney and testis, in which oxygen levels are hovering closely to hypoxia under normal conditions.	Oxygen	102-108	tuftelin 1	Mus musculus	25-33
23700162-4	2013	Concomitantly, physiological conditions associated with varying oxygen tension often highlight the importance of Siah, as seen in cancer and neurodegenerative disorders.	Oxygen	64-70	cubitus interruptus	Drosophila melanogaster	113-117
15548613-1	2004	Neuroglobin (Ngb), a globular heme protein expressed in the brain of vertebrates, binds oxygen reversibly, with an affinity comparable to myoglobin (Mb).	Oxygen	88-94	neuroglobin	Mus musculus	13-16
15452132-7	2004	Abeta1-42-induced production of ceramide was redox-sensitive, as reactive oxygen species were involved in the activation of N-SMase but not A-SMase.	Oxygen	74-80	sphingomyelin phosphodiesterase 2	Homo sapiens	124-131
17077816-8	2007	When SCap fell below approximately 70% with reduced flow and inspired oxygen tension, PMitoO2 decreased (P&lt;0.001) and brain lactate release increased concomitantly (P&lt;0.001).	Oxygen	70-76	SREBF chaperone	Homo sapiens	5-9
23039020-7	2013	LC-NMR analysis indicated an intact aziridine ring and opened macrolactone ring, resulting in D1 and D2, an isomeric hydroxy acid pair resulting from an alkyl oxygen cleavage.	Oxygen	159-165	leiomodin 1	Homo sapiens	94-103
17293559-0	2007	Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.	Oxygen	143-149	glutamate receptor, metabotropic 3	Mus musculus	73-78
15485853-7	2004	COS-7 cells co-transfected with Gyc-88E and Gyc-89Da or Gyc-89Db accumulate low levels of cGMP under normal atmospheric oxygen concentrations and are potently activated under anoxic conditions.	Oxygen	120-126	Guanylyl cyclase at 88E	Drosophila melanogaster	32-39
15485853-9	2004	Gyc-88E and Gyc-89Db are co-expressed in a subset of sensory neurons where they would be ideally situated to act as oxygen sensors.	Oxygen	116-122	Guanylyl cyclase at 88E	Drosophila melanogaster	0-7
17303406-8	2007	In addition, the SREBP pathway has been found to regulate a diverse set of cellular processes, including phagocytosis, cell cycle progression, oxygen sensing and survival in response to bacterial infection.	Oxygen	143-149	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	17-22
23684916-11	2013	Data suggest that TNF-alpha-induced BAFF expression and BAFF-mediated VEGF expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments.	Oxygen	217-223	TNF superfamily member 13b	Homo sapiens	56-60
15286002-6	2004	Breathing 11% oxygen for 3 wk increased mean pulmonary arterial pressure, pulmonary vascular resistance, and hemoglobin concentration to similar levels in BMPR-II(+/-) and wild-type mice, but the degree of muscularization of small pulmonary arteries and formation of alveolar-capillary units were reduced in BMPR-II(+/-) mice.	Oxygen	14-20	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	155-162
15286002-6	2004	Breathing 11% oxygen for 3 wk increased mean pulmonary arterial pressure, pulmonary vascular resistance, and hemoglobin concentration to similar levels in BMPR-II(+/-) and wild-type mice, but the degree of muscularization of small pulmonary arteries and formation of alveolar-capillary units were reduced in BMPR-II(+/-) mice.	Oxygen	14-20	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	308-315
17234681-3	2007	IL-18 was constitutively expressed in the retina in C57BL/6 mice, but expression transiently dropped on Day 17 after birth in mice exposed to 75% oxygen for 5 days between Days 7 and 12.	Oxygen	146-152	interleukin 18	Mus musculus	0-5
17234681-4	2007	Coincident with the IL-18 reduction in oxygen-treated mice, vascular endothelial growth factor was expressed in the retina, and OIR developed.	Oxygen	39-45	interleukin 18	Mus musculus	20-25
23951165-5	2013	As other solid tumors, EWS are reliant on a functional vascular network for the delivery of nutrients and oxygen and for the removal of waste.	Oxygen	106-112	EWS RNA binding protein 1	Homo sapiens	23-26
17234681-6	2007	By contrast, IL-18 knockout mice, exposed to elevated oxygen concentrations, developed more severe OIR on Day 17, and it is important that this persisted until Day 24.	Oxygen	54-60	interleukin 18	Mus musculus	13-18
17395040-5	2007	For moderate established RIF, current management strategy mainly includes (1) anti-inflammatory treatment with corticosteroids or interferon gamma; (2) vascular therapy with pentoxifylline (PTX) or hyperbaric oxygen (HBO); and (3) antioxidant treatment with superoxide dismutase, tocopherol (vitamin E), and, most successfully, with a PTX-vitamin E combination.	Oxygen	209-215	ras homolog family member F, filopodia associated	Homo sapiens	25-28
17298084-9	2007	Rapid reaction studies confirm that reduction of the flavin center of Erv2p is rate-limiting during turnover with molecular oxygen.	Oxygen	124-130	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	70-75
15528033-2	2004	In this study, we evaluated whether genetic inactivation of Prdx6 in mice increases sensitivity to oxygen toxicity.	Oxygen	99-105	peroxiredoxin 6	Mus musculus	60-65
15528033-5	2004	After 72-h exposure to 100% O(2), lungs of Prdx6-/- mice showed more severe injury than wild-type with increased wet/dry weight, epithelial cell necrosis and alveolar edema on microscopic examination, increased protein and nucleated cells in BALF, and higher content of TBARS and protein carbonyls in lung homogenate.	Oxygen	28-32	peroxiredoxin 6	Mus musculus	43-48
15642321-4	2004	The objective of this study was to assess the expression of MMPs and their regulators in an oxidative stress model of cataract, where epithelial cell death and cortical fibre cell swelling occurs in rat lenses after exposure to riboflavin, oxygen, and light.	Oxygen	240-246	matrix metallopeptidase 2	Rattus norvegicus	60-64
15642322-9	2004	Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR).	Oxygen	98-100	superoxide dismutase 2	Homo sapiens	151-156
15328343-8	2004	Together, these studies indicate that PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response.	Oxygen	100-106	protein phosphatase 5 catalytic subunit	Homo sapiens	38-41
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	inversin S homeolog	Xenopus laevis	48-52
15269007-4	2004	In both cases, the P50 in patients was elevated 2.1- and 3.3-fold, respectively, indicating decreased affinity of COX for oxygen.	Oxygen	122-128	cytochrome c oxidase subunit 8A	Homo sapiens	114-117
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	inversin S homeolog	Xenopus laevis	93-97
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	nephronophthisis 3 (adolescent) L homeolog	Xenopus laevis	98-103
23792098-8	2013	Our studies indicate that reduced expression of SBDS decreases mitochondrial membrane potential and oxygen consumption and increases the production of reactive oxygen species.	Oxygen	100-106	SBDS ribosome maturation factor	Homo sapiens	48-52
15529381-12	2004	MMP-9 mRNA was dramatically decreased by IL-1beta only in low oxygen tension.	Oxygen	62-68	matrix metallopeptidase 9	Bos taurus	0-5
15529381-12	2004	MMP-9 mRNA was dramatically decreased by IL-1beta only in low oxygen tension.	Oxygen	62-68	interleukin 1 beta	Bos taurus	41-49
15529381-16	2004	CONCLUSION: Oxygen level and reoxygenation stress significantly modulate gene expression and the response of articular chondrocytes to cytokines such as IL-1beta.	Oxygen	12-18	interleukin 1 beta	Bos taurus	153-161
15529381-18	2004	In low oxygen tension, high IL-1beta-induced NO production is associated with a significant decrease in PGE(2) synthesis.	Oxygen	7-13	interleukin 1 beta	Bos taurus	28-36
24024174-7	2013	Finally, PDI was detected on the surface RBC under ~100% oxygen saturation and released as soluble under ~50% oxygen saturation.	Oxygen	57-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	9-12
15298879-9	2004	RESULTS: During ventilation with oxygen-AIRc, the median nitric oxide concentration was 5.6 ppb, during ventilation with oxygen-nitrous oxide it was 5.0 ppb and using oxygen-AIRs it was 1.5 ppb.	Oxygen	33-39	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	40-44
24024174-7	2013	Finally, PDI was detected on the surface RBC under ~100% oxygen saturation and released as soluble under ~50% oxygen saturation.	Oxygen	110-116	prolyl 4-hydroxylase subunit beta	Homo sapiens	9-12
24024174-8	2013	The soluble PDI detected under ~50% oxygen saturation was S-nitrosylated.	Oxygen	36-42	prolyl 4-hydroxylase subunit beta	Homo sapiens	12-15
15544971-4	2004	We propose that a second far less studied protein, metal transcription factor-1 (MTF-1), acts as a more general oxygen sensor, responding to both hypoxia and oxidative stress, and is also intimately involved in malignant progression.	Oxygen	112-118	metal regulatory transcription factor 1	Homo sapiens	51-79
24024174-10	2013	Hb-Fe(II)-NO that is formed from nitrite reduction under ~50% O2, then transfers NO(+) to either Hb-Cys beta93 or directly to PDI resulting in S-nitroso-PDI which transverses the RBC membrane and attaches to the RBC surface.	Oxygen	62-64	prolyl 4-hydroxylase subunit beta	Homo sapiens	126-129
15544971-4	2004	We propose that a second far less studied protein, metal transcription factor-1 (MTF-1), acts as a more general oxygen sensor, responding to both hypoxia and oxidative stress, and is also intimately involved in malignant progression.	Oxygen	112-118	metal regulatory transcription factor 1	Homo sapiens	81-86
24024174-10	2013	Hb-Fe(II)-NO that is formed from nitrite reduction under ~50% O2, then transfers NO(+) to either Hb-Cys beta93 or directly to PDI resulting in S-nitroso-PDI which transverses the RBC membrane and attaches to the RBC surface.	Oxygen	62-64	prolyl 4-hydroxylase subunit beta	Homo sapiens	153-156
24024174-11	2013	When RBCs enter tissues the S-nitroso-PDI is released from the RBC-surface into the blood where its NO(+) is transferred into the endothelium thereby inducing vasodilation, suggesting local oxygen-dependent dynamic interplays between nitrite, NO and S-nitrosylation.	Oxygen	190-196	prolyl 4-hydroxylase subunit beta	Homo sapiens	38-41
23562913-0	2013	Role of HIF1alpha and PKCbeta in mediating the effect of oxygen and glucose in a novel wound assay.	Oxygen	57-63	protein kinase C beta	Homo sapiens	22-29
15308630-4	2004	The precursor form of D1 (pD1) contains a C-terminal extension, which is removed by the protease CtpA to yield PSII complexes with oxygen evolution activity.	Oxygen	131-137	programmed cell death 1	Homo sapiens	26-29
15483690-0	2004	Quantum chemical studies of dioxygen activation by mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad.	Oxygen	28-36	viral integration site 1	Homo sapiens	96-101
23609497-0	2013	Apobec-1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats.	Oxygen	24-30	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	0-8
15489981-1	2004	Biphasic BMI[middle dot]PF(6)/toluene solvent is a remarkably suitable and clean medium for performing olefin metathesis with a new 2nd generation ionic liquid supported-ruthenium catalyst: high levels of recyclability and reusability combined with a high reactivity were obtained with a variety of di- or tri-substituted and/or oxygen-containing dienes, and very low residual ruthenium levels were detected (1 to 22 ppm) in the products.	Oxygen	329-335	sperm associated antigen 17	Homo sapiens	24-29
23609497-8	2013	Apobec-1 could upregulate COX-2 expression in neurogenic cells by stabilizing COX-2 mRNA, and might aggravate injury of oxygen-glucose deprivation in neurogenic cells as well as in rats with cerebral ischemia.	Oxygen	120-126	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	0-8
15449937-2	2004	In beta-thalassemia major, where there is beta-chain production failure, HbA(2) acts as the predominant oxygen deliverer.	Oxygen	104-110	hemoglobin subunit alpha 2	Homo sapiens	73-79
23957201-0	2013	P38 activation is more important than ERK activation in lung injury induced by prolonged hyperbaric oxygen.	Oxygen	100-106	mitogen activated protein kinase 14	Rattus norvegicus	0-3
15456874-3	2004	Here, we show that c-Jun-/- MEF can proliferate successfully in low oxygen (3% O2), indicating that premature senescence under conventional culture conditions is a consequence of hyperoxic stress.	Oxygen	68-74	jun proto-oncogene	Mus musculus	19-24
15456874-3	2004	Here, we show that c-Jun-/- MEF can proliferate successfully in low oxygen (3% O2), indicating that premature senescence under conventional culture conditions is a consequence of hyperoxic stress.	Oxygen	68-74	E74-like factor 4 (ets domain transcription factor)	Mus musculus	28-31
15456874-3	2004	Here, we show that c-Jun-/- MEF can proliferate successfully in low oxygen (3% O2), indicating that premature senescence under conventional culture conditions is a consequence of hyperoxic stress.	Oxygen	79-81	jun proto-oncogene	Mus musculus	19-24
15456874-3	2004	Here, we show that c-Jun-/- MEF can proliferate successfully in low oxygen (3% O2), indicating that premature senescence under conventional culture conditions is a consequence of hyperoxic stress.	Oxygen	79-81	E74-like factor 4 (ets domain transcription factor)	Mus musculus	28-31
15456874-4	2004	c-Jun-/- MEF exhibit higher basal levels of DNA damage compared to normal fibroblasts in high but not low oxygen, implying that senescence results from chronic accumulation of spontaneous DNA damage.	Oxygen	106-112	jun proto-oncogene	Mus musculus	0-5
15456874-4	2004	c-Jun-/- MEF exhibit higher basal levels of DNA damage compared to normal fibroblasts in high but not low oxygen, implying that senescence results from chronic accumulation of spontaneous DNA damage.	Oxygen	106-112	E74-like factor 4 (ets domain transcription factor)	Mus musculus	9-12
23957201-4	2013	The results showed that the ERK and p38 were phosphorylated at two hours and reached a peak at six hours into exposure to hyperbaric oxygen.	Oxygen	133-139	mitogen activated protein kinase 14	Rattus norvegicus	36-39
23957201-7	2013	However, caspase-3 was activated at six hours and 10 hours into exposure to hyperbaric oxygen.	Oxygen	87-93	caspase 3	Rattus norvegicus	9-18
23957201-8	2013	These results demonstrated different changes of activation of ERK and p38 during lung injury induced by prolonged exposure to hyperbaric oxygen.	Oxygen	137-143	mitogen activated protein kinase 14	Rattus norvegicus	70-73
23957201-9	2013	The time course changes of activated caspase-3 were similar to the process of p38 activation upon exposure to hyperbaric oxygen.	Oxygen	121-127	caspase 3	Rattus norvegicus	37-46
15543949-8	2004	T3 stimulated CD73 activity and expression of the cells, suggesting that this effect could promote an increase in adenosine formation and, therefore, has an important modulatory role in the elicitation of responses that serve to restore the tissue oxygen supply-to-demand ratio back to normal.	Oxygen	248-254	5' nucleotidase, ecto	Rattus norvegicus	14-18
23957201-9	2013	The time course changes of activated caspase-3 were similar to the process of p38 activation upon exposure to hyperbaric oxygen.	Oxygen	121-127	mitogen activated protein kinase 14	Rattus norvegicus	78-81
23957201-10	2013	In this way, activation of p38, not ERK, seems to be a mechanism associated with prolonged hyperbaric oxygen-induced lung injury.	Oxygen	102-108	mitogen activated protein kinase 14	Rattus norvegicus	27-30
26283246-2	2013	It is demonstrated that the effect of quantum tunneling corrections for the reaction HO2 + HO2 = H2O2 + O2 can have a noticeable impact on the performance of a high-fidelity model of a compression-ignition (e.g., diesel) engine, and that an accurate prediction of ignition delay time for the engine model requires an accurate estimation of the tunneling correction for this reaction.	Oxygen	86-88	heme oxygenase 2	Homo sapiens	91-94
15286980-7	2004	Expression of granzyme A (gzmA) was found to be significantly regulated by oxygen tension with cells at 5% pO(2) having greater gzmA expression than at 20% pO(2).	Oxygen	75-81	granzyme A	Homo sapiens	14-24
15286980-7	2004	Expression of granzyme A (gzmA) was found to be significantly regulated by oxygen tension with cells at 5% pO(2) having greater gzmA expression than at 20% pO(2).	Oxygen	75-81	granzyme A	Homo sapiens	26-30
23785149-0	2013	Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner.	Oxygen	81-87	necdin, MAGE family member	Mus musculus	0-6
15212809-7	2004	Further, the addition of CIPC caused an increase in the rate of State 4 oxygen consumption, indicating an uncoupling effect, and a decrease in the rate of State 3 oxygen consumption in a concentration-dependent manner, respectively.	Oxygen	72-78	CLOCK-interacting pacemaker	Rattus norvegicus	25-29
15212809-7	2004	Further, the addition of CIPC caused an increase in the rate of State 4 oxygen consumption, indicating an uncoupling effect, and a decrease in the rate of State 3 oxygen consumption in a concentration-dependent manner, respectively.	Oxygen	163-169	CLOCK-interacting pacemaker	Rattus norvegicus	25-29
23785149-11	2013	These results suggest that oxygen tension regulates the necdin protein level in NSCs through HIF-2alpha-mediated proteasomal degradation to modulate their proliferation and apoptosis.	Oxygen	27-33	necdin, MAGE family member	Mus musculus	56-62
15235597-5	2004	Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension.	Oxygen	240-246	C-X-C motif chemokine ligand 12	Homo sapiens	18-23
23225569-1	2013	The prolyl-4-hydroxylase domain 1-3 (PHD1-3) enzymes are regulating the protein stability of the alpha-subunit of the hypoxia-inducible factor-1 (HIF-1), which mediates oxygen-dependent gene expression.	Oxygen	169-175	egl-9 family hypoxia inducible factor 2	Homo sapiens	37-43
15235597-5	2004	Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension.	Oxygen	240-246	C-X-C motif chemokine ligand 12	Homo sapiens	183-188
23692429-4	2013	O2 reduction at FTO occurs at -0.33 V vs NHE, allowing for in situ detection of oxygen as it is formed by water oxidation on the surface.	Oxygen	0-2	solute carrier family 9 member C1	Homo sapiens	41-44
15347446-1	2004	OBJECTIVE: Reduced oxygen availability at a high altitude is associated with increased pulmonary arterial pressure (PAP).	Oxygen	19-25	phospholipid phosphatase 1	Mus musculus	116-119
15257580-2	2004	The dicopper(I) complex reacted with molecular oxygen at a low temperature to give an unprecedented mu-peroxo dicopper(II) complex presumably having a mu-eta1:eta2 binding mode, the spectroscopic features and the reactivity of which have been explored in detail.	Oxygen	47-53	DNA polymerase iota	Homo sapiens	159-163
17319734-5	2007	The successive dehydration of II forms III, which possibly has an active oxygen species of a mu-eta2:eta2-peroxo group.	Oxygen	73-79	DNA polymerase iota	Homo sapiens	96-100
17319734-5	2007	The successive dehydration of II forms III, which possibly has an active oxygen species of a mu-eta2:eta2-peroxo group.	Oxygen	73-79	DNA polymerase iota	Homo sapiens	101-105
25983366-5	2007	The production of singlet oxygen can be expressed as etaD, where eta is the singlet oxygen quantum yield and is a constant under ample oxygen supply.	Oxygen	26-32	endothelin receptor type A	Homo sapiens	53-56
25983366-8	2007	We have shown that it is possible to express eta as a function of local oxygen concentration during PDT and this expression is a good approximation to predict the production of singlet oxygen during PDT.	Oxygen	72-78	endothelin receptor type A	Homo sapiens	45-48
15280069-12	2004	Concomitant ET(A)/ET(B) receptor activation increased microcirculatory failure and decreased tissue oxygen even without NOS inhibition.	Oxygen	100-106	endothelin receptor type A	Homo sapiens	12-17
23692429-4	2013	O2 reduction at FTO occurs at -0.33 V vs NHE, allowing for in situ detection of oxygen as it is formed by water oxidation on the surface.	Oxygen	80-86	solute carrier family 9 member C1	Homo sapiens	41-44
15140880-10	2004	Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion.	Oxygen	80-86	neuroglobin	Danio rerio	0-11
15140880-10	2004	Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion.	Oxygen	174-180	neuroglobin	Danio rerio	0-11
16920014-7	2007	OLE1 is regulated through Spt23p and Mga2p by multiple systems that control its transcription and mRNA stability in response to diverse stimuli that include nutrient fatty acids, carbon source, metal ions and the availability of oxygen.	Oxygen	229-235	Mga2p	Saccharomyces cerevisiae S288C	37-42
23692429-5	2013	Controlled-potential electrolysis at 1.61 V vs NHE at pH 7.2 resulted in sustained water oxidation catalysis at a current density of 0.16 mA/cm(2) with 29,000 turnovers per site over an electrolysis period of 2 h. The turnover frequency for oxygen production per Co site was 4 s(-1) at an overpotential of 800 mV at pH 7.2.	Oxygen	241-247	solute carrier family 9 member C1	Homo sapiens	47-50
23545307-5	2013	Overexpression of AQP1, 3 or 5 in PC12 cells (o-AQP-c) prevented the HIF-2alpha down-expression otherwise observed, after 16 h at 1% O2, in wt-PC12 and in PC12 overexpressing non-AQP proteins.	Oxygen	133-135	aquaporin 1	Rattus norvegicus	18-22
16949254-3	2007	Here, we studied Ang1-induced capillary morphogenesis in human umbilical-vein endothelial cells (HUVECs) cultured chronically under normoxic (21% oxygen) or hypoxic (1.5% oxygen) conditions.	Oxygen	146-152	angiopoietin 1	Homo sapiens	17-21
15178343-1	2004	The recent identification of hypoxia-inducible-factor (HIF) prolyl hydroxylases (PHD1, 2, and 3), which modify HIF-1 alpha in an oxygen-dependent manner, provided an important link between oxygen availability and hypoxia-induced gene expression.	Oxygen	189-195	egl-9 family hypoxia inducible factor 2	Homo sapiens	81-95
15084514-3	2004	The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specific recognition of hydroxylated Pro-402 or Pro-564, both of which are modified by the oxygen-dependent HIF prolyl hydroxylases (PHDs/HPHs).	Oxygen	164-170	von Hippel-Lindau tumor suppressor	Homo sapiens	4-21
15084514-3	2004	The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specific recognition of hydroxylated Pro-402 or Pro-564, both of which are modified by the oxygen-dependent HIF prolyl hydroxylases (PHDs/HPHs).	Oxygen	164-170	von Hippel-Lindau tumor suppressor	Homo sapiens	23-26
16949254-3	2007	Here, we studied Ang1-induced capillary morphogenesis in human umbilical-vein endothelial cells (HUVECs) cultured chronically under normoxic (21% oxygen) or hypoxic (1.5% oxygen) conditions.	Oxygen	171-177	angiopoietin 1	Homo sapiens	17-21
23591450-10	2013	Transcriptional assays endorsed the notion that PCAF may be involved in the determination of the SCO2 and TIGAR cellular levels, thereby, regulating cellular energy metabolism, a view supported by assays measuring lactic acid production and oxygen consumption in cells ectopically expressing PCAF.	Oxygen	241-247	lysine acetyltransferase 2B	Homo sapiens	48-52
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Oxygen	68-74	haptoglobin-related protein	Homo sapiens	28-31
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Oxygen	68-74	haptoglobin-related protein	Homo sapiens	141-144
15199406-4	2004	After combined oxygen-glucose deprivation, Ung(-/-) primary cortical neurons have increased vulnerability to cell death, which is associated with early mitochondrial dysfunction.	Oxygen	15-21	uracil DNA glycosylase	Mus musculus	43-46
23623520-13	2013	A Cox model of proportional hazards, adjusted for sex, age, GOLD stage, heart failure, malignant disease, and long-term oxygen treatment, demonstrated that intervention reduced the risk of COPD hospitalization (hazard ratio 0.43, 95% confidence interval 0.24-0.77, P = .002).	Oxygen	120-126	COPD	Homo sapiens	189-193
15150283-5	2004	In 3% O(2), hCG showed the same initial decline but failed to recover thereafter.	Oxygen	6-10	glycoprotein hormones, alpha polypeptide	Homo sapiens	12-15
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Oxygen	68-74	haptoglobin-related protein	Homo sapiens	141-144
23467670-3	2013	The gene-deletion mutants were further assayed for sensitivity to ferrozine and cobalt to obtain a subset of 34 oxygen-responsive candidate genes including the known hypoxic gene activator, MGA2.	Oxygen	112-118	Mga2p	Saccharomyces cerevisiae S288C	190-194
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	4-10	solute carrier family 2 member 1	Bos taurus	183-204
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	4-10	solute carrier family 2 member 1	Bos taurus	206-212
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	236-242	solute carrier family 2 member 1	Bos taurus	183-204
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	236-242	solute carrier family 2 member 1	Bos taurus	206-212
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	236-242	solute carrier family 2 member 1	Bos taurus	183-204
16998843-1	2007	Low oxygen conditions (2%) during post-compaction culture of bovine blastocysts improve embryo quality, which is associated with a small yet significant increase in the expression of glucose transporter 1 (GLUT-1), suggesting a role of oxygen in embryo development mediated through oxygen-sensitive gene expression.	Oxygen	236-242	solute carrier family 2 member 1	Bos taurus	206-212
17266307-2	2007	These enzymes are part of the superfamily of dioxygen-activating mononuclear non-heme iron enzymes that feature the so-called 2-His-1-carboxylate facial triad.	Oxygen	45-53	viral integration site 1	Homo sapiens	128-133
14966119-0	2004	Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function.	Oxygen	25-33	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	40-54
14966119-0	2004	Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function.	Oxygen	25-33	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	106-120
15014982-8	2004	Apparently a Saccharomyces yeast progenitor which had a eukaryotic-like mitochondrial DHODase acquired a bacterial gene for DHODase, which subsequently allowed cell growth gradually to become independent of oxygen.	Oxygen	207-213	dihydroorotate dehydrogenase	Saccharomyces cerevisiae S288C	86-93
15014982-8	2004	Apparently a Saccharomyces yeast progenitor which had a eukaryotic-like mitochondrial DHODase acquired a bacterial gene for DHODase, which subsequently allowed cell growth gradually to become independent of oxygen.	Oxygen	207-213	dihydroorotate dehydrogenase	Saccharomyces cerevisiae S288C	124-131
15121835-3	2004	In earlier work using genetically manipulated mouse embryo fibroblasts (mEFs), we found a functional relationship among c-jun expression, c-Jun N-terminal phosphorylation, and the presence of hypoxia-inducible factor 1 alpha (HIF-1 alpha), the oxygen-regulated subunit of the HIF-1 transcription factor.	Oxygen	244-250	jun proto-oncogene	Mus musculus	120-125
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Oxygen	254-260	hemoglobin subunit alpha 1	Homo sapiens	195-199
23467670-6	2013	Knockdown experiments for CNOT8, human homolog of POP2, reduced cell survival under low oxygen condition suggesting a similar function in human cells.	Oxygen	88-94	CCR4-NOT transcription complex subunit 8	Homo sapiens	26-31
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Oxygen	254-260	hemoglobin subunit alpha 2	Homo sapiens	210-214
23467670-6	2013	Knockdown experiments for CNOT8, human homolog of POP2, reduced cell survival under low oxygen condition suggesting a similar function in human cells.	Oxygen	88-94	CCR4-NOT transcription complex subunit 8	Homo sapiens	50-54
15252684-2	2004	[Fe(Hdmg)(2)(MeIm)(2)](1), referred to as ferroxime(II), is the precursor of a selective catalyst for the oxidative dehydrogenation of 2-aminophenol (Hap) to 2-amino-3H-phenoxazine-3-one (apx) by dioxygen under ambient conditions.	Oxygen	196-204	reticulon 3	Homo sapiens	150-153
23425865-2	2013	METHODS: Oxygen of the glycoside bond of sialoside was replaced with sulfur to prevent hydrolytic digestion of the N-acetylneuraminic acid residue by viral neuraminidase.	Oxygen	9-15	neuraminidase 1	Homo sapiens	156-169
15252684-5	2004	According to the proposed mechanism, solvolysis of 1 is followed by O(2) binding to afford a superoxoferroxime, which abstracts an H-atom from Hap in the rate-determining step via an H-bonded intermediate, generating the free radical.	Oxygen	68-72	reticulon 3	Homo sapiens	143-146
14734545-1	2004	The hypoxia-inducible factor alpha subunits 1 and 2 (HIF-1alpha and HIF-2alpha) are subjected to oxygen-dependent asparaginyl hydroxylation, a modification that represses the carboxyl-terminal transactivation domain (CAD) at normoxia by preventing recruitment of the p300/cAMP-response element-binding protein coactivators.	Oxygen	97-103	E1A binding protein p300	Homo sapiens	267-271
17071723-6	2007	After exposure to 85% O(2), primary alveolar type II cells were more susceptible to TGF-beta-induced apoptosis, whereas primary pulmonary artery smooth muscle cells were unaffected.	Oxygen	22-26	transforming growth factor, beta 1	Mus musculus	84-92
17071723-7	2007	Exposure of primary lung fibroblasts to 85% O(2) significantly enhanced the TGF-beta-stimulated production of the alpha(1) subunit of type I collagen (Ialpha(1)), tissue inhibitor of metalloproteinase-1, tropoelastin, and tenascin-C.	Oxygen	44-48	transforming growth factor, beta 1	Mus musculus	76-84
23696843-1	2013	Cytochrome c oxidase is the terminal enzyme in the electron transfer chain of essentially all organisms that utilize oxygen to generate energy.	Oxygen	117-123	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
17287564-4	2007	Mean-while, water loss results in increased activities of reactive-oxygen-scavenging enzymes (SOD, CAT, APX and GR).	Oxygen	67-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	104-107
17209556-0	2007	Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.	Oxygen	48-54	DNA polymerase beta	Homo sapiens	140-159
14702352-4	2004	Since the transcriptional regulation of several genes involved in angiogenesis during hypoxia is mediated by hypoxia-inducible factor-1 (HIF-1), it was conceivable that Ang2 expression might be regulated by the same oxygen-dependent mechanism.	Oxygen	216-222	angiopoietin 2	Homo sapiens	169-173
23699409-3	2013	Here we report that constitutive mammalian target of rapamycin complex 1 (mTORC1) activity renders hypoxic cells dependent on exogenous desaturated lipids, as levels of de novo synthesized unsaturated fatty acids are reduced under low O2.	Oxygen	235-237	CREB regulated transcription coactivator 1	Mus musculus	74-80
17209638-6	2007	The state of O2 trapped in the cavity of CoTpivPP was distinctly observed in STM images as a bright spot in the nanobelt array formed on reconstructed Au(100)-(hex) surface, but not on Au(111) surface.	Oxygen	13-15	hematopoietically expressed homeobox	Homo sapiens	160-163
23671581-1	2013	Hypoxia-inducible factor 1alpha (HIF1alpha) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP.	Oxygen	152-158	E1A binding protein p300	Homo sapiens	218-222
17038435-0	2007	Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport.	Oxygen	89-95	myoglobin	Rattus norvegicus	0-9
14980636-2	2004	Among the three series of macrocycles, the oxygen atom and thiophene containing linkers yielded molecules with higher inhibitory potency at GSK-3 beta (K(i)=0.011-0.079 microM) while the nitrogen atom containing linkers yielded molecules with lower potency (K(i)=0.150-&gt;1 microM).	Oxygen	43-49	glycogen synthase kinase 3 beta	Homo sapiens	140-150
15031665-6	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Oxygen	183-189	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	83-85	myoglobin	Rattus norvegicus	56-65
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	83-85	myoglobin	Rattus norvegicus	67-69
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	128-130	myoglobin	Rattus norvegicus	56-65
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	128-130	myoglobin	Rattus norvegicus	67-69
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	128-130	myoglobin	Rattus norvegicus	56-65
17038435-1	2007	Current theory of respiratory control invokes a role of myoglobin (Mb)-facilitated O2 diffusion in regulating the intracellular O2 flux, provided Mb diffusion can compete effectively with free O2 diffusion.	Oxygen	128-130	myoglobin	Rattus norvegicus	67-69
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
15268544-2	2004	For short atomic oxygen exposures, CF-SAMs remain intact, an effect ascribed to the inertness of C-F and C-C bonds toward atomic oxygen and the well-ordered structure of the CF-SAMs.	Oxygen	17-23	methionine adenosyltransferase 1A	Homo sapiens	177-181
15268544-5	2004	In contrast, the reactivity of atomic oxygen with alkanethiolate SAMs is initiated at the vacuum/film interface, producing oxygen-containing carbon functional groups.	Oxygen	38-44	methionine adenosyltransferase 1A	Homo sapiens	65-69
15268544-5	2004	In contrast, the reactivity of atomic oxygen with alkanethiolate SAMs is initiated at the vacuum/film interface, producing oxygen-containing carbon functional groups.	Oxygen	123-129	methionine adenosyltransferase 1A	Homo sapiens	65-69
14980311-6	2004	RESULTS: : At 20% oxygen there was significantly reduced MMP-2 (P &lt; .05) and TIMP-1 (P &lt; .01) release and a trend for decreased MMP-9 release (P = .07) in explants from IUGR pregnancies compared with normal pregnancies; however, there were no differences at 3% oxygen.	Oxygen	18-24	matrix metallopeptidase 2	Homo sapiens	57-62
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
23349051-5	2013	We sought to determine oxygen-derived effects on the anti-inflammatory A2A adenosinergic (ADORA2A) receptor in macrophages, and the role of the ADORA2A receptor in lung injury.	Oxygen	23-29	adenosine A2a receptor	Mus musculus	90-97
17038435-3	2007	Given values in the literature for the Krogh"s free O2 diffusion coefficient (K0), myocardial Mb concentration and a partial pressure of O2 that half saturates Mb (P50), the analysis yields an equipoise diffusion P(O2) of 1.77 mmHg, where Mb and free O2 contribute equally to the O2 flux.	Oxygen	137-139	myoglobin	Rattus norvegicus	160-162
17038435-4	2007	In the myocardium, Mb-facilitated O2 diffusion contributes increasingly more than free O2 diffusion when the P(O2) falls below 1.77 mmHg.	Oxygen	34-36	myoglobin	Rattus norvegicus	19-21
17038435-8	2007	Because the basal P(O2) hovers around 10 mmHg, Mb does not have a predominant role in facilitating O2 transport in myocardium but contributes significantly only when cellular oxygen falls below the equipoise diffusion P(O2).	Oxygen	20-22	myoglobin	Rattus norvegicus	47-49
14730659-9	2004	Similarly, maximal TA MCP-1, MCP-2, and MCP-3 but not MIP-1alpha and MIP-1beta concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks of postconceptional age (PCA) than those who were not oxygen-dependent at 36 weeks PCA.	Oxygen	140-146	C-C motif chemokine ligand 8	Homo sapiens	29-34
23349051-10	2013	Compared with WT mice, ADORA2A(-/-) mice exposed to IT LPS and 60% oxygen demonstrated significantly more histologic lung injury, alveolar neutrophils, and protein.	Oxygen	67-73	adenosine A2a receptor	Mus musculus	23-30
17038435-8	2007	Because the basal P(O2) hovers around 10 mmHg, Mb does not have a predominant role in facilitating O2 transport in myocardium but contributes significantly only when cellular oxygen falls below the equipoise diffusion P(O2).	Oxygen	175-181	myoglobin	Rattus norvegicus	47-49
23635653-5	2013	The increased sensitivity of PC3/2G7 tumors to antiangiogenesis indicates they are less tolerant of low vascularity and suggests they become addicted to their oxygen- and nutrient-rich environment.	Oxygen	159-165	chromobox 8	Mus musculus	29-36
17939209-10	2007	LOX-1 expression increased also through oxygen species (ROS), endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-alpha), shear stress, activation of protein kinase-C (PKC), angiotensin-II (ANG-II), and through inflammatory pathways.	Oxygen	40-46	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
18269196-8	2007	In zebrafish and turtle, however, which live in an environment with naturally changing oxygen conditions, hypoxia dramatically increases Ngb expression in the brains.	Oxygen	87-93	neuroglobin	Danio rerio	137-140
18269196-10	2007	These data suggest that Ngb may have a myoglobin-like role and supplies oxygen to the respiratory chain of the metabolically highly active neurons, or protect them from reactive oxygen species.	Oxygen	72-78	neuroglobin	Danio rerio	24-27
18269196-12	2007	Cygb levels are significantly elevated at low oxygen levels in the fibroblast cell lineage.	Oxygen	46-52	cytoglobin 1	Danio rerio	0-4
14752287-7	2004	Thus, it appears that AT most likely reduces F-actin formation in neutrophil by binding to glycosaminoglycans (e.g., syndecan-4) on the neutrophil, thereby reducing neutrophil accumulation in the lung, which would in turn inhibit oxygen radical production in the lung.	Oxygen	230-236	syndecan 4	Rattus norvegicus	117-127
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	E1A binding protein p300	Homo sapiens	94-98
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	E1A binding protein p300	Homo sapiens	132-136
14719919-4	2004	In the present study, to convert a simple oxygen storage hemoprotein, myoglobin, into an active peroxidase, we applied both methods at the same time.	Oxygen	42-48	myoglobin	Physeter catodon	70-79
14719919-10	2004	In this system, a highly oxidized heme reactive species is smoothly generated and a substrate is effectively bound in the heme pocket, while native myoglobin only reversibly binds dioxygen.	Oxygen	180-188	myoglobin	Physeter catodon	148-157
23537075-0	2013	Oxygen attachment on alkanethiolate SAMs induced by low-energy electron irradiation.	Oxygen	0-6	methionine adenosyltransferase 1A	Homo sapiens	36-40
15880895-4	2004	These changes in ADH could be induced either by spaceflight hypoxia resulting from inhibition of gravity mediated O2 transport, or by a non-specific stress response due to inhibition of gravisensing.	Oxygen	114-116	alcohol dehydrogenase 1	Arabidopsis thaliana	17-20
17245122-1	2007	The von Hippel-Lindau (VHL) protein is a critical regulator of the ubiquitous oxygen-sensing pathway.	Oxygen	78-84	von Hippel-Lindau tumor suppressor	Homo sapiens	4-21
23537075-2	2013	Dosing the SAMs with (18)O2 at 50 K results in the ESD of (18)O(-) and (18)OH(-).	Oxygen	25-27	methionine adenosyltransferase 1A	Homo sapiens	11-15
18029431-1	2007	The current British Thoracic Society guidelines on COPD recommend that patients with COPD exacerbations should be admitted to hospital if they either have partial pressure of arterial oxygen of &lt;7.0 kilopascals (kPa) or if they are living alone.	Oxygen	184-190	COPD	Homo sapiens	51-55
18029431-1	2007	The current British Thoracic Society guidelines on COPD recommend that patients with COPD exacerbations should be admitted to hospital if they either have partial pressure of arterial oxygen of &lt;7.0 kilopascals (kPa) or if they are living alone.	Oxygen	184-190	COPD	Homo sapiens	85-89
23537075-4	2013	A minimum incident electron energy of 6-7 eV is required to initiate the binding of (18)O2 to the SAMs.	Oxygen	88-90	methionine adenosyltransferase 1A	Homo sapiens	98-102
23416151-10	2013	Correspondingly, exposing murine microglial BV2 cells to hypoxia (1% O2) for 20h resulted in an increased expression of TNF-alpha, CD14, iNOS, and nitrotyrosine.	Oxygen	69-71	CD14 antigen	Mus musculus	131-135
17084552-4	2007	The effect of oxygen (2% vs. 20%) on CD133 expression was measured.	Oxygen	14-20	prominin 1	Homo sapiens	37-42
15117600-0	2004	The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2.	Oxygen	32-38	matrix metallopeptidase 2	Homo sapiens	77-103
15117600-3	2004	We hypothesize that MMP-2 release is enhanced in endothelial cells from preeclamptic compared with uncomplicated pregnancies and that this phenomenon may be mediated by an oxygen-dependent mechanism.	Oxygen	172-178	matrix metallopeptidase 2	Homo sapiens	20-25
15117600-4	2004	Our specific hypothesis is that cells from normal pregnancies will demonstrate enhanced MMP-2 release at low oxygen (&lt; 0.5%, 2%) compared to high oxygen (20%), thus mimicking the behavior of preeclamptic cells.	Oxygen	109-115	matrix metallopeptidase 2	Homo sapiens	88-93
15117600-9	2004	MMP-2 release from HUVECs from uncomplicated pregnancies was significantly elevated at 2% oxygen compared to &lt; 0.5% and 20% oxygen (p &lt; 0.05).	Oxygen	90-96	matrix metallopeptidase 2	Homo sapiens	0-5
15117600-9	2004	MMP-2 release from HUVECs from uncomplicated pregnancies was significantly elevated at 2% oxygen compared to &lt; 0.5% and 20% oxygen (p &lt; 0.05).	Oxygen	127-133	matrix metallopeptidase 2	Homo sapiens	0-5
17084552-7	2007	Culturing Daoy cells in 2% oxygen rather than the standard 20% oxygen increased their CD133 expression 1.6-fold.	Oxygen	27-33	prominin 1	Homo sapiens	86-91
17084552-7	2007	Culturing Daoy cells in 2% oxygen rather than the standard 20% oxygen increased their CD133 expression 1.6-fold.	Oxygen	63-69	prominin 1	Homo sapiens	86-91
15117600-12	2004	Our data show that there are significant effects of oxygen tension on MMP-2 release from normal cells; however, the magnitude of the enhanced release is small when compared to the differences in MMP-2 release in cells from preeclamptic and normal pregnancies.	Oxygen	52-58	matrix metallopeptidase 2	Homo sapiens	70-75
23476056-1	2013	RATIONALE: NADPH oxidase (Nox) 2 and Nox4 are major components of the Nox family which purposefully produce reactive oxidative species, namely O2(-) and H2O2, in the heart.	Oxygen	143-145	NADPH oxidase 4	Mus musculus	37-41
14702300-0	2004	Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress.	Oxygen	115-121	AT695_RS07555	Staphylococcus aureus	56-67
14702300-0	2004	Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress.	Oxygen	115-121	AT695_RS07555	Staphylococcus aureus	72-83
14702300-1	2004	In this report we describe the cloning, organization, and promoter analysis of the Staphylococcus aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription in response to changes in oxygen concentration and to oxidative stress compounds.	Oxygen	213-219	AT695_RS07555	Staphylococcus aureus	105-116
14702300-1	2004	In this report we describe the cloning, organization, and promoter analysis of the Staphylococcus aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription in response to changes in oxygen concentration and to oxidative stress compounds.	Oxygen	213-219	AT695_RS07555	Staphylococcus aureus	128-139
17197509-6	2007	In contrast, the mutant ND4 disrupted mitochondrial cytoarchitecture, elevated reactive oxygen species, induced swelling of the optic nerve head, and induced apoptosis, with a progressive demise of ganglion cells in the retina and their axons comprising the optic nerve.	Oxygen	88-94	NADH dehydrogenase 4, mitochondrial	Mus musculus	24-27
17070589-4	2007	The VHL protein is required for oxygen-dependent degradation of hypoxia-inducible factor 1alpha.	Oxygen	32-38	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
17593476-11	2007	CONCLUSION: It was concluded that EGF affects oral wound healing by downregulating both the lipid peroxidation and NOx levels, and it may thus be considered to be an oxygen radical scavenger.	Oxygen	166-172	pro-epidermal growth factor	Oryctolagus cuniculus	34-37
14522996-11	2003	The observed enzyme-catalyzed formation of a labile 1"-acetylated-ADP-fluororibose intermediate using beta-2"-deoxy-2"-fluororibo-NAD+ supports a mechanism where, after nicotinamide-ribosyl cleavage, the carbonyl oxygen of acetylated substrate attacks the C-1" ribose to form an initial iminium adduct.	Oxygen	213-219	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-108
23445365-6	2013	The binding of DMQn (n = 0 or 2) to GB1-hCLK-1 mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates O2 activation for subsequent DMQ hydroxylation.	Oxygen	145-147	CDC like kinase 1	Homo sapiens	40-46
14625032-1	2003	Trans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma.	Oxygen	83-89	solute carrier family 12 member 3	Rattus norvegicus	26-29
14625032-2	2003	The current study is the initial investigation of the effects of TSC on oxygen delivery to brain.	Oxygen	72-78	solute carrier family 12 member 3	Rattus norvegicus	65-68
14625032-6	2003	TSC significantly increased brain tissue oxygen delivery.	Oxygen	41-47	solute carrier family 12 member 3	Rattus norvegicus	0-3
16956955-2	2006	At the molecular level, the details of P450 catalysis are still under investigation, but the importance of water-mediated proton shuttles seems evident in the catalytic cycle as it progresses through various heme iron-oxygen enzyme intermediates.	Oxygen	218-224	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-43
23480348-5	2013	Very importantly, the as-prepared PAH functionalized Pd icosahedra exhibit superior electrocatalytic activity and ethanol tolerant ability toward the oxygen reduction reaction (ORR) compared to the commercially available Pt black in alkaline media.	Oxygen	150-156	phenylalanine hydroxylase	Homo sapiens	34-37
16979164-0	2006	Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization.	Oxygen	88-94	LDL receptor related protein 1	Rattus norvegicus	0-50
16979164-0	2006	Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization.	Oxygen	88-94	LDL receptor related protein 1	Rattus norvegicus	52-57
16979164-3	2006	In order to test this assumption, we investigated the expression of LRP-1 and receptor-associated ligands in a rat model of oxygen-induced retinal neovascularization.	Oxygen	124-130	LDL receptor related protein 1	Rattus norvegicus	68-73
16979164-9	2006	Western blot analysis showed that LRP-1 was expressed, along with alpha2M, in the retina of rats with oxygen-induced neovascularization at P20.	Oxygen	102-108	LDL receptor related protein 1	Rattus norvegicus	34-39
16979164-9	2006	Western blot analysis showed that LRP-1 was expressed, along with alpha2M, in the retina of rats with oxygen-induced neovascularization at P20.	Oxygen	102-108	alpha-2-macroglobulin	Rattus norvegicus	66-73
14636048-10	2003	This study demonstrated that the hydroxyl oxygens of Thr14 and to a lesser extent Thr 6 represent the two dominant substrates modified by ppGalNAc-T1 within the context of a complex MUC1 peptide substrate.	Oxygen	42-49	mucin 1, cell surface associated	Homo sapiens	182-186
15124929-6	2003	The models suggest that an interaction between the inhibitor"s catechol oxygens and the Mg2+ ion in the COMT active site is important.	Oxygen	72-79	catechol-O-methyltransferase	Homo sapiens	104-108
16979164-14	2006	In retinas of rats with oxygen-induced neovascularization, the expression of LRP-1 and alpha2M was increased along with an enhanced activity of MMPs, suggesting that LRP-1 expression may play a role in modulating retinal neovascularization by regulating proteolytic activity.	Oxygen	24-30	LDL receptor related protein 1	Rattus norvegicus	77-82
23395094-7	2013	Blockade of IRE1alpha or ATF6 in the oxygen-induced retinopathy or choroidal neovascularization mouse models caused an approximately 35% reduction in angiogenesis.	Oxygen	37-43	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	12-21
16979164-14	2006	In retinas of rats with oxygen-induced neovascularization, the expression of LRP-1 and alpha2M was increased along with an enhanced activity of MMPs, suggesting that LRP-1 expression may play a role in modulating retinal neovascularization by regulating proteolytic activity.	Oxygen	24-30	alpha-2-macroglobulin	Rattus norvegicus	87-94
16979164-14	2006	In retinas of rats with oxygen-induced neovascularization, the expression of LRP-1 and alpha2M was increased along with an enhanced activity of MMPs, suggesting that LRP-1 expression may play a role in modulating retinal neovascularization by regulating proteolytic activity.	Oxygen	24-30	matrix metallopeptidase 2	Rattus norvegicus	144-148
16979164-14	2006	In retinas of rats with oxygen-induced neovascularization, the expression of LRP-1 and alpha2M was increased along with an enhanced activity of MMPs, suggesting that LRP-1 expression may play a role in modulating retinal neovascularization by regulating proteolytic activity.	Oxygen	24-30	LDL receptor related protein 1	Rattus norvegicus	166-171
15002859-4	2003	The first test was a graded run to estimate maximal aerobic speed (SMA), i.e., the minimal speed which elicited maximal oxygen uptake.	Oxygen	120-126	survival of motor neuron 1, telomeric	Homo sapiens	67-70
14691554-2	2003	The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for degradation in the presence of oxygen.	Oxygen	210-216	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
14691554-2	2003	The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for degradation in the presence of oxygen.	Oxygen	210-216	von Hippel-Lindau tumor suppressor	Homo sapiens	22-26
16953504-6	2006	The important vulcanization accelerator mercaptobenzothiazole (C(7)H(5)NS(2), MBT) containing several donor sites reacts with the Zn(4)O(4) cluster with proton transfer from the NH group to one of the oxygen atoms of ZnO, and in addition the exocyclic thiono sulfur atom and the nitrogen atom coordinate to one and the same zinc atom, resulting in a binding energy of -247 kJ mol(-1).	Oxygen	201-207	proteinase 3	Homo sapiens	78-81
23395094-7	2013	Blockade of IRE1alpha or ATF6 in the oxygen-induced retinopathy or choroidal neovascularization mouse models caused an approximately 35% reduction in angiogenesis.	Oxygen	37-43	activating transcription factor 6	Mus musculus	25-29
22936709-6	2013	Compared to controls, Bmpr2(R899X) mice showed increased weight gain and demonstrated insulin resistance as assessed by the homeostatic model assessment insulin resistance (1.0 +- 0.4 versus 2.2 +- 1.8) and by fat accumulation in skeletal muscle and decreased oxygen consumption.	Oxygen	260-266	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	22-27
16981895-1	2006	Brain energy metabolism essentially depends on the availability of oxygen representing the energetic substrate for cytochrome c oxidase (COX).	Oxygen	67-73	cytochrome c oxidase subunit 8A	Homo sapiens	137-140
16981895-7	2006	Under conditions of oxygen deprivation, transcription of COX IV-2 is induced in astrocytes and further up-regulated in cerebellar granule cells.	Oxygen	20-26	cytochrome c oxidase subunit 4I2	Homo sapiens	57-65
16981895-10	2006	This suggests a pivotal role of COX as an oxygen sensor for brain function.	Oxygen	42-48	cytochrome c oxidase subunit 8A	Homo sapiens	32-35
16962353-7	2006	Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions.	Oxygen	65-71	arginine deiminase	Escherichia coli	10-14
14640058-5	2003	In addition to this, beta 2-agonists increase the metabolism and cause ventilation-perfusion mismatch in the lung which may lead to a decrease in the oxygen saturation.	Oxygen	150-156	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	21-27
14640058-7	2003	Beneficial clinical effects of beta 2-agonists are a reduction in breathing frequency, reduction in or disappearance of retractions or the use of accessory respiratory muscles during breathing and possibly an increase in oxygen saturation.	Oxygen	221-227	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	31-37
14597738-2	2003	Here, we describe that oxygen availability is a determinant parameter in the setting of chemotactic responsiveness to stromal-derived factor 1 (CXCL12).	Oxygen	23-29	C-X-C motif chemokine ligand 12	Homo sapiens	144-150
14597738-3	2003	Low oxygen concentration induces high expression of the CXCL12 receptor, CXC receptor 4 (CXCR4), in different cell types (monocytes, monocyte-derived macrophages, tumor-associated macrophages, endothelial cells, and cancer cells), which is paralleled by increased chemotactic responsiveness to its specific ligand.	Oxygen	4-10	C-X-C motif chemokine ligand 12	Homo sapiens	56-62
23340741-2	2013	CD133 recognition may, however, be affected by its glycosylation             pattern and oxygen tension.	Oxygen	89-95	prominin 1	Homo sapiens	0-5
14620813-3	2003	We fitted a previously developed kinetic model to the experimental data to determine the critical rate constants, kf for the formation of Fe(II)--NOM complexes and kox for the oxygenation of the Fe(II)--NOM complexes, when assumed to be first order with respect to both the concentration of Fe(II) and the dissolved O2.	Oxygen	316-318	NADPH oxidase 4	Homo sapiens	164-167
12957143-2	2003	Changes in PEDF levels have been correlated with development of retinal neovascularization in oxygen-induced retinopathy.	Oxygen	94-100	serpin family F member 1	Homo sapiens	11-15
17047753-2	2006	All three oxygen species form very weak complexes with toluene and all also appear capable of abstracting a benzylic hydrogen atom to form the HO2 radical.	Oxygen	10-16	heme oxygenase 2	Homo sapiens	143-146
16905536-2	2006	The first is the oxidized state of enzyme isolated in the fast form (O) and the second is the form that is obtained immediately after oxidation of fully reduced CcO with O2 (OH).	Oxygen	170-172	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	161-164
23340741-3	2013	The present study investigates the effect of oxygen             deprivation on CD133 expression and glycosylation status employing a high AC133-expressing             glioblastoma multiforme (GBM) cell line, IN699.	Oxygen	45-51	prominin 1	Homo sapiens	79-84
16887802-3	2006	Two biochemical features have been linked to structural properties by comparing the structures of short chain-specific Arabidopsis thaliana ACX4 with and without a substrate analogue bound in the active site to known acyl-CoA oxidases and dehydrogenase structures: (i) a solvent-accessible acyl binding pocket is not required for oxygen reactivity, and (ii) the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity.	Oxygen	330-336	acyl-CoA oxidase 4	Arabidopsis thaliana	140-144
23288553-1	2013	The extremely high energy demand elicited by sprint exercise is satisfied by an increase in O2 consumption combined with a high glycolytic rate, leading to a marked lactate accumulation, increased AMP-to-ATP ratio, and reduced NAD(+)/NADH.H(+) and muscle pH, which are accompanied by marked Thr(172) AMP-activated protein kinase (AMPK)-alpha phosphorylation during the recovery period by a mechanism not fully understood.	Oxygen	92-94	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	330-334
16887802-3	2006	Two biochemical features have been linked to structural properties by comparing the structures of short chain-specific Arabidopsis thaliana ACX4 with and without a substrate analogue bound in the active site to known acyl-CoA oxidases and dehydrogenase structures: (i) a solvent-accessible acyl binding pocket is not required for oxygen reactivity, and (ii) the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity.	Oxygen	446-452	acyl-CoA oxidase 4	Arabidopsis thaliana	140-144
14573790-4	2003	Mitochondrial analysis revealed that PLS3(F258V)-expressing cells have decreased mitochondrial mass shown by lower cytochrome c and cardiolipin (CL) content, poor mitochondrial respiration, and reduced oxygen consumption and intracellular ATP; whereas wild-type PLS3-transfected cells exhibit increased mitochondrial mass and enhanced respiration.	Oxygen	202-208	phospholipid scramblase 3	Homo sapiens	37-41
17020258-5	2006	The Raman spectra and the calculations together indicate that Li+ coordinates bidentately with two end-oxygen atoms of the BOB- anion.	Oxygen	103-109	G protein-coupled receptor 15	Homo sapiens	123-126
12851211-3	2003	After 60 h of hyperoxia (&gt;95% O2), mRNA and protein levels of 1-cysPrx and peroxidase activity were significantly elevated in rat lungs by approximately 1.5- to 2-fold compared with the control (P &lt; 0.05).	Oxygen	33-35	peroxiredoxin 6	Mus musculus	65-73
23232626-7	2013	There were positive correlations between the percentage of radionuclide injected per gram of brain tissue and rCBF supply and cerebral metabolic rate for oxygen (P &lt; 0.05).	Oxygen	154-160	CCAAT/enhancer binding protein zeta	Rattus norvegicus	110-114
12851211-4	2003	A similar induction of 1-cysPrx was observed in mouse lungs following exposure to O2 for 63 or 72 h; enzyme induction in mouse lungs was similar for wild-type and glutathione peroxidase 1 gene-targeted mice.	Oxygen	82-84	peroxiredoxin 6	Mus musculus	23-31
14527176-1	2003	In the present report, we show that bovine articular chondrocytes cultured in low oxygen tension, i.e. in conditions mimicking their hypoxic in vivo environment, respond to IL-1beta (10 ng/mL) by an increased DNA binding activity of NF-kappaB and AP-1 transcription factors.	Oxygen	82-88	interleukin 1 beta	Bos taurus	173-181
16751292-7	2006	SNO-hemoglobin dispenses NO bioactivity to microvascular cells on the release of oxygen, physiologically coupling hemoglobin deoxygenation to vasodilation.	Oxygen	81-87	strawberry notch homolog 1	Homo sapiens	0-3
14527176-5	2003	Rhein was capable of reducing the IL-1beta-stimulated ERK1/ERK2 pathway whatever the tension of oxygen present in the environment.	Oxygen	96-102	interleukin 1 beta	Bos taurus	34-42
23098688-6	2013	As a result of their catalytic and non-catalytic functions, ALDH3A1 and ALDH1A1 proteins protect inner ocular tissues from ultraviolet radiation and reactive oxygen-induced damage.	Oxygen	158-164	aldehyde dehydrogenase 3 family member A1	Homo sapiens	60-67
12901768-4	2003	The simultaneous change of Phi and SEE in the case of oxygen covered tungsten have been pointed out and a direct relationship between them can be supposed.	Oxygen	54-60	glucose-6-phosphate isomerase	Homo sapiens	27-30
17040097-1	2006	The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively.	Oxygen	190-196	aryl hydrocarbon receptor	Homo sapiens	4-29
17040097-1	2006	The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively.	Oxygen	190-196	aryl hydrocarbon receptor	Homo sapiens	31-34
18648594-11	2006	Recent findings suggest that employment of DR and multiple antioxidant agents (including, catalase, glutathione peroxidase, CuZn superoxide dismutase, and Mn superoxide dismutase = enzymes forming the primary defense against oxygen toxicity), and ozone therapy may mount an effective resistance to pathogenic factors relevant to the pathogenesis of cardiovascular episodes.	Oxygen	225-231	superoxide dismutase 2	Homo sapiens	155-178
16970413-2	2006	This is the same percentage increase that TSC causes in the diffusivity of oxygen through water.	Oxygen	75-81	solute carrier family 12 member 3	Homo sapiens	42-45
22422580-8	2013	Cystatin C was correlated with Apnea Hypopnea Index (AHI), Oxygen Desaturation Index, hsCRP, creatinine, and estimated glomerular filtration rate (r = 0.319, 0.279, 0.321, 0.233, -0.241, p = 0.001, 0.005, 0.001, 0.021, 0.017, respectively).	Oxygen	59-65	cystatin C	Homo sapiens	0-10
16942016-3	2006	However, SAR studies and analysis of the crystal structure of human PNMT (hPNMT) in complex with 7 indicated that the sulfonamide oxygens, and not the sulfonamide -NH-, formed favorable interactions with the enzyme.	Oxygen	130-137	phenylethanolamine N-methyltransferase	Homo sapiens	68-72
16942016-3	2006	However, SAR studies and analysis of the crystal structure of human PNMT (hPNMT) in complex with 7 indicated that the sulfonamide oxygens, and not the sulfonamide -NH-, formed favorable interactions with the enzyme.	Oxygen	130-137	phenylethanolamine N-methyltransferase	Homo sapiens	74-79
16942016-8	2006	We also report the crystal structure of hPNMT in complex with sulfonamide 15, from which a potential hydrogen bond acceptor within the hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39.	Oxygen	198-204	phenylethanolamine N-methyltransferase	Homo sapiens	40-45
23464170-3	2013	Using the optimed PBE - van der Waals (oPBE-vdW) functional, which includes van der Waals forces on an ab initio level, it is shown that the molecule has two binding sites, a carboxyl and the hydroxyl oxygen atoms.	Oxygen	201-207	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	18-21
16969113-1	2006	The ubiquitin-mediated degradation of hypoxia-inducible factor-alpha (HIF-alpha) by a von Hippel-Lindau tumor suppressor protein (pVHL) is mechanistically responsible for controlling gene expression due to oxygen availability.	Oxygen	206-212	von Hippel-Lindau tumor suppressor	Homo sapiens	130-134
24280108-6	2013	However, glutamine significantly induced oxygen consumption in the presence of MYC which was dependent on aminotransferases.	Oxygen	41-47	myelocytomatosis oncogene	Mus musculus	79-82
16740971-7	2006	Cytochrome P450 side-chain cleavage enzyme (P450scc) mRNA expression, measured by quantitative PCR, decreased under low-oxygen condition in both non-LH-treated and LH-treated cells.	Oxygen	120-126	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	44-51
16740971-10	2006	The overall results indicate that a low-oxygen condition decreases P4 synthesis by attenuating P450scc production and P450scc activity in bovine luteal cells and suggest that oxygen deficiency is an essential condition for the progression of luteolysis in cattle.	Oxygen	40-46	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	95-102
16740971-10	2006	The overall results indicate that a low-oxygen condition decreases P4 synthesis by attenuating P450scc production and P450scc activity in bovine luteal cells and suggest that oxygen deficiency is an essential condition for the progression of luteolysis in cattle.	Oxygen	40-46	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	118-125
23314690-6	2013	Hypermethylation with low oxygen tension was independently confirmed by bisulfite-pyrosequencing in a subset of functionally relevant genes including CD59, CFB, GRAM3 and ZNF217.	Oxygen	26-32	complement factor B	Homo sapiens	156-159
16804678-5	2006	The detailed hydrogen-bonding geometries depicted in the active site of nNOS structures indicate that it is the ordered active-site water molecule rather than the substrate itself that would most likely serve as a direct proton donor to the diatomic ligands (CO, NO, as well as O(2)) bound to the heme.	Oxygen	278-283	nitric oxide synthase 1	Homo sapiens	72-76
22987685-1	2013	Hemoglobin (Hb), an oxygen-binding protein composed of four subunits (alpha1, alpha2, beta1, and beta2), is a well-known example of allosteric proteins that are capable of cooperative ligand binding.	Oxygen	20-26	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	97-102
16929296-2	2006	This is because the only mechanism known to produce MIF-S has been ultraviolet photolysis of volcanic sulphur dioxide gas in an oxygen-poor atmosphere.	Oxygen	128-134	macrophage migration inhibitory factor	Homo sapiens	52-55
23340651-5	2013	Our results demonstrate that 3% O(2) augmented proliferation of BMSC, as well as the formation of colonies in the colony-forming unit assay (CFU-A), the percentage of quiescent cells, and the expression of stemness markers Rex-1 and Oct-4, thereby suggesting an increase in the stemness of culture when exposed to hypoxia.	Oxygen	32-36	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	233-238
23188833-7	2013	We show that YUC6 uses NADPH and oxygen to convert IPA to IAA.	Oxygen	33-39	Flavin-binding monooxygenase family protein	Arabidopsis thaliana	13-17
16893708-11	2006	In conclusion, NT-pro-BNP levels correlate with peak oxygen consumption in HC and are more predictive of functional impairment than other conventional markers of disease severity.	Oxygen	53-59	natriuretic peptide B	Homo sapiens	22-25
17102090-5	2006	Germline mutations in VHL and HIF1 prolyl hydroxylase 2 genes cause polycythemia consistent with their role in oxygen homeostasis.	Oxygen	111-117	von Hippel-Lindau tumor suppressor	Homo sapiens	22-25
23188723-0	2013	Retinal vascular rescue of oxygen-induced retinopathy in mice by norrin.	Oxygen	27-33	Norrie disease (pseudoglioma) (human)	Mus musculus	65-71
16855386-9	2006	This is the first time that CaM-K inhibition is reported to sensitize cancer cells to reactive oxygen intermediate inducing cancer treatments.	Oxygen	95-101	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	28-33
16873253-0	2006	Kaposi"s sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions.	Oxygen	158-164	LANA	Human gammaherpesvirus 8	55-59
23141926-8	2013	In the oxygen-induced retinopathy model of retinopathy of prematurity, PGC-1alpha expression is dramatically induced in the inner nuclear layer of the retina, suggesting that PGC-1alpha drives pathological neovascularization.	Oxygen	7-13	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	71-81
16873253-3	2006	Here we show that the latency-associated nuclear antigen (LANA), which plays a crucial role in modulating viral and cellular gene expression, directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).	Oxygen	173-179	LANA	Human gammaherpesvirus 8	58-62
23141926-8	2013	In the oxygen-induced retinopathy model of retinopathy of prematurity, PGC-1alpha expression is dramatically induced in the inner nuclear layer of the retina, suggesting that PGC-1alpha drives pathological neovascularization.	Oxygen	7-13	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	175-185
23141926-9	2013	In support of this, PGC-1alpha(-/-) mice subjected to oxygen-induced retinopathy had decreased expression of VEGFA and were protected against pathological neovascularization.	Oxygen	54-60	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	20-30
24565326-3	2013	The giant protein titin is stretched and can unfold during muscle contraction providing passive elasticity to muscle tissue; myoglobin adsorbs and releases oxygen molecules thank to conformational changes in its structure; the outer membrane protein G (OmpG) is a bacterial porin with a long and flexible loop that modulates gating; and the proton pump bacteriorhodopsin adapts its cytosolic half to allow proton pumping.	Oxygen	156-162	titin	Homo sapiens	18-23
23037927-3	2013	OBJECTIVE: To characterize the acute hemodynamic response to short-term oxygen supplementation (SHOT) in adult PH patients and its impact on prognosis.	Oxygen	72-78	short stature homeobox 2	Homo sapiens	96-100
22731854-7	2013	MSCs expanded with 20% oxygen contained a greater proportion of senescent cells than those under physiological oxygen levels, indicated by a three to fourfold increase in beta-galactosidase staining.	Oxygen	23-29	galactosidase beta 1	Homo sapiens	171-189
23144459-3	2012	Low steady-state levels of H(2)S appear to be controlled primarily by efficient oxygen-dependent catabolism via sulfide quinone oxidoreductase, persulfide dioxygenase (ETHE1), rhodanese, and sulfite oxidase.	Oxygen	80-86	ETHE1 persulfide dioxygenase	Homo sapiens	168-173
23187810-3	2012	The recruitment of p67phox to the cell membrane causes the activation of the NADPH oxidase complex followed by the generation of NADP+ and superoxide from molecular oxygen.	Oxygen	165-171	neutrophil cytosolic factor 2	Homo sapiens	19-26
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	carbonic anhydrase 9	Homo sapiens	298-302
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	carbonic anhydrase 9	Homo sapiens	304-325
12637268-0	2003	Posttranslational inactivation of human xanthine oxidoreductase by oxygen under standard cell culture conditions.	Oxygen	67-73	xanthine dehydrogenase	Homo sapiens	40-63
23028049-4	2012	NCoR1 muscle-specific knockout mice exhibited a 7.2% higher peak oxygen consumption (VO(2peak)), a 11% reduction in maximal isometric force, and increased ex vivo fatigue resistance during maximal stimulation.	Oxygen	65-71	nuclear receptor co-repressor 1	Mus musculus	0-5
12637268-1	2003	Xanthine oxidoreductase (XOR) catalyzes the final reactions of purine catabolism and may account for cell damage by producing reactive oxygen metabolites in cells reoxygenated after hypoxia.	Oxygen	135-141	xanthine dehydrogenase	Homo sapiens	0-23
12637268-1	2003	Xanthine oxidoreductase (XOR) catalyzes the final reactions of purine catabolism and may account for cell damage by producing reactive oxygen metabolites in cells reoxygenated after hypoxia.	Oxygen	135-141	xanthine dehydrogenase	Homo sapiens	25-28
12637268-2	2003	We found a three- to eightfold higher XOR activity in cultured human bronchial epithelial cells exposed to hypoxia (0.5-3% O2) compared with cells grown in normoxia (21% O2) but no difference in XOR protein or mRNA.	Oxygen	123-125	xanthine dehydrogenase	Homo sapiens	38-41
12637268-2	2003	We found a three- to eightfold higher XOR activity in cultured human bronchial epithelial cells exposed to hypoxia (0.5-3% O2) compared with cells grown in normoxia (21% O2) but no difference in XOR protein or mRNA.	Oxygen	170-172	xanthine dehydrogenase	Homo sapiens	38-41
12637268-4	2003	The cellular XOR activity at 3% O2 returned to basal levels when the cells were returned to 21% O2, and hyperoxia (95% O2) abolished enzyme activity with no change in XOR protein.	Oxygen	32-34	xanthine dehydrogenase	Homo sapiens	13-16
12637268-4	2003	The cellular XOR activity at 3% O2 returned to basal levels when the cells were returned to 21% O2, and hyperoxia (95% O2) abolished enzyme activity with no change in XOR protein.	Oxygen	96-98	xanthine dehydrogenase	Homo sapiens	13-16
23081803-4	2012	Accordingly, the encapsulation of the highly luminescent [Ru(dpp)(3)](2+)-type (dpp=4,7-diphenyl-1,10-phenanthroline) core unit within a dendritic microenvironment creates a powerful means to shield the center from dioxygen quenching.	Oxygen	215-223	dentin sialophosphoprotein	Homo sapiens	61-64
12637268-4	2003	The cellular XOR activity at 3% O2 returned to basal levels when the cells were returned to 21% O2, and hyperoxia (95% O2) abolished enzyme activity with no change in XOR protein.	Oxygen	96-98	xanthine dehydrogenase	Homo sapiens	13-16
12890374-1	2003	OBJECTIVE: To evaluate the effectiveness of a helium-oxygen mixture (79%He- 21%O(2)) as an aerosolizing compressed gas for beta(2)-agonist therapy in patients with an asthma exacerbation.	Oxygen	53-59	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	123-129
23081803-4	2012	Accordingly, the encapsulation of the highly luminescent [Ru(dpp)(3)](2+)-type (dpp=4,7-diphenyl-1,10-phenanthroline) core unit within a dendritic microenvironment creates a powerful means to shield the center from dioxygen quenching.	Oxygen	215-223	dentin sialophosphoprotein	Homo sapiens	80-83
12890374-1	2003	OBJECTIVE: To evaluate the effectiveness of a helium-oxygen mixture (79%He- 21%O(2)) as an aerosolizing compressed gas for beta(2)-agonist therapy in patients with an asthma exacerbation.	Oxygen	79-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	123-129
23006780-5	2012	Oxygen-toxicity significantly induced upregulation of peroxiredoxins 1 and 2, peroxiredoxin sulfonic form, thioredoxin 1, and sulfiredoxin 1 in the brains of infant rats.	Oxygen	0-6	sulfiredoxin 1	Homo sapiens	126-140
12827456-5	2003	Solutions of CGH-CONH(2) with nickel(II) at neutral pH yielded a red nickel-thiolate complex, but at higher pH (8.5 or above) or with exposure to dioxygen, yellow nickel complexes with N-terminal amino coordination were observed.	Oxygen	146-154	hypertrichosis 2 (generalised, congenital)	Homo sapiens	13-16
22770562-9	2012	Changes in Ang-2 during follow-up correlated with partial pressure of oxygen in arterial blood (PaO(2))/fraction of inspired oxygen (FiO(2)) ratio, alveolar-arterial oxygen tension difference (AaDO(2)), hemodynamics, fluid balance, and disease severity measures.	Oxygen	70-76	angiopoietin 2	Homo sapiens	11-16
12781920-1	2003	Nitric oxide (NO) from endothelial or neuronal NO synthases (eNOS or nNOS) may contribute both to the cerebrovascular responses to oxygen and potentially to the peroxynitrite-mediated toxic effects of hyperbaric oxygen (HBO(2)) on the central nervous system (CNS O(2) toxicity).	Oxygen	131-137	nitric oxide synthase 1, neuronal	Mus musculus	69-73
22770562-9	2012	Changes in Ang-2 during follow-up correlated with partial pressure of oxygen in arterial blood (PaO(2))/fraction of inspired oxygen (FiO(2)) ratio, alveolar-arterial oxygen tension difference (AaDO(2)), hemodynamics, fluid balance, and disease severity measures.	Oxygen	125-131	angiopoietin 2	Homo sapiens	11-16
12781920-1	2003	Nitric oxide (NO) from endothelial or neuronal NO synthases (eNOS or nNOS) may contribute both to the cerebrovascular responses to oxygen and potentially to the peroxynitrite-mediated toxic effects of hyperbaric oxygen (HBO(2)) on the central nervous system (CNS O(2) toxicity).	Oxygen	212-218	nitric oxide synthase 1, neuronal	Mus musculus	69-73
12868493-1	2003	This experiment was performed to clarify the role of extracellular signal-regulated kinase, ERK1/2, in NADPH oxidase-dependent O2- production in rat peritoneal neutrophils.	Oxygen	127-129	mitogen activated protein kinase 3	Rattus norvegicus	92-98
12868493-2	2003	When neutrophils were exposed to N-formyl-methionyl-leucyl-phenylalanine (fMLP) to stimulate an N-formyl peptide receptor, not only the production of O2- but also the activation of ERK1/2 was observed.	Oxygen	150-152	mitogen activated protein kinase 3	Rattus norvegicus	181-187
12868493-4	2003	U0126, an ERK1/2 kinase inhibitor, inhibited both the production of O2- and the translocation of p47(phox) elicited by fMLP.	Oxygen	68-70	mitogen activated protein kinase 3	Rattus norvegicus	10-16
22770562-9	2012	Changes in Ang-2 during follow-up correlated with partial pressure of oxygen in arterial blood (PaO(2))/fraction of inspired oxygen (FiO(2)) ratio, alveolar-arterial oxygen tension difference (AaDO(2)), hemodynamics, fluid balance, and disease severity measures.	Oxygen	125-131	angiopoietin 2	Homo sapiens	11-16
12938735-6	2003	Mice with endowed defences against superoxide or with deficiency in the nNOS and iNOS are protected from MPTP toxicity suggesting that formation of reactive oxygen and nitrogen intermediates both intracellularly and extracellularly contributes to the demise of dopaminergic neurons.	Oxygen	157-163	nitric oxide synthase 1, neuronal	Mus musculus	72-76
22999007-6	2012	Overall, the macroscopic PEM degradation mitigation rate was lowered by up to 2 orders of magnitude using nonstoichiometric ceria nanoparticles with high surface oxygen vacancy concentrations.	Oxygen	162-168	mucin 1, cell surface associated	Homo sapiens	25-28
12730690-9	2003	In vitro, T lymphocytes isolated from oxygen-exposed neonates induced a FasL-mediated apoptosis of hyperoxygenated endothelial cells.	Oxygen	38-44	Fas ligand	Rattus norvegicus	72-76
22914753-9	2012	This study confirmed that priming exercise results in an improved O2 delivery as shown by the decreased [HHb]/Vo2) ratio that was related to the smaller tauVo2 in Mod2.	Oxygen	66-68	chromobox 3	Homo sapiens	163-167
12696880-1	2003	Phenylalanine hydroxylase, a mononuclear non-heme iron enzyme, catalyzes the hydroxylation of phenylalanine to tyrosine in the presence of oxygen and reduced pterin cofactor.	Oxygen	139-145	phenylalanine hydroxylase	Homo sapiens	0-25
22718311-8	2012	While each member of the PSBP protein family contains a similar domain to the PSBP1 protein, which is a member of the oxygen evolving complex of photosystem II (PSII), the PSBP2 protein does not appear to be involved in PSII function, but may function as a sensor and/or signal mediating molecule of the (1)O(2) generated in the chloroplast.	Oxygen	118-124	uncharacterized protein	Chlamydomonas reinhardtii	78-83
12686129-3	2003	Both in GO and CAO, formation of a superoxide ion that leads to the creation of a radical pair is experimentally suggested to be the rate-limiting step in the dioxygen reduction process.	Oxygen	159-167	amine oxidase copper containing 3	Homo sapiens	15-18
16832501-1	2006	A novel chain-like silver polyoxotungstophosphate is formed when Ag(I) metal centres, exhibiting an unusual eight-coordination fashion, bridge a monolacunary [PW11O39]7- anion to four bridging mu2-oxygen atoms of a neighbouring lacunary alpha-Keggin anion.	Oxygen	197-203	adaptor related protein complex 1 subunit mu 2	Homo sapiens	193-196
22962263-7	2012	Our findings show how miR-210 induction links hypoxia to immune escape from CTL-mediated lysis, by providing a mechanistic understanding of how this miRNA mediates immunosuppression in oxygen-deprived regions of tumors where cancer stem-like cells and metastatic cellular behaviors are known to evolve.	Oxygen	185-191	microRNA 210	Homo sapiens	22-29
16854127-3	2006	The proton exchange membrane (PEM) fuel cell employing the self-humidifying membrane (Pt-SiO2/NP) turns out a peak power density of 1.40 W cm(-2) and an open circuit voltage (OCV) of 1.032 V under dry H2/O2 condition.	Oxygen	91-93	mucin 1, cell surface associated	Homo sapiens	30-33
12722881-3	2003	VHL appears to be a pivotal gene in the oxygen-sensing pathway, mainly involved in targeting the hypoxia-inducible factors for ubiquitination.	Oxygen	40-46	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
22229392-2	2012	We previously reported 24 h of 100% O(2) increased phosphodiesterase 5 (PDE5) activity in fetal pulmonary artery smooth muscle cells (FPASMC) and in ventilated neonatal lambs.	Oxygen	36-40	PDE5A	Ovis aries	51-70
12788661-2	2003	Since myoglobin, found in cardiac myocytes and red skeletal muscle, but not in the liver, facilitates oxygen diffusion under low oxygen conditions and enhances oxidative phosphorylation, this study seeks to enhance hepatic ATP levels and attenuate ischemia-reperfusion injury in rodent livers by adenovirus-mediated myoglobin expression.	Oxygen	102-108	myoglobin	Rattus norvegicus	6-15
12788661-2	2003	Since myoglobin, found in cardiac myocytes and red skeletal muscle, but not in the liver, facilitates oxygen diffusion under low oxygen conditions and enhances oxidative phosphorylation, this study seeks to enhance hepatic ATP levels and attenuate ischemia-reperfusion injury in rodent livers by adenovirus-mediated myoglobin expression.	Oxygen	129-135	myoglobin	Rattus norvegicus	6-15
12538644-5	2003	We demonstrate that the common oxygen-dependent degradation domain of hHIF-3 alpha 1-3 splice variants is targeted for ubiquitylation by the pVHL complex in vitro and in vivo.	Oxygen	31-37	von Hippel-Lindau tumor suppressor	Homo sapiens	141-145
16569214-1	2006	nNOS (neuronal nitric oxide synthase) is a constitutively expressed enzyme responsible for the production of NO* from L-arginine and O2.	Oxygen	133-135	nitric oxide synthase 1	Homo sapiens	0-4
22229392-2	2012	We previously reported 24 h of 100% O(2) increased phosphodiesterase 5 (PDE5) activity in fetal pulmonary artery smooth muscle cells (FPASMC) and in ventilated neonatal lambs.	Oxygen	36-40	PDE5A	Ovis aries	72-76
16821877-1	2006	This behavior of the SPR band, upon exposure to CO, was not observed when using nitrogen as the carrier gas, indicating an oxygen-dependent reaction mechanism.	Oxygen	123-129	sepiapterin reductase	Homo sapiens	21-24
22922640-8	2012	The irradiance response of photosynthetic oxygen evolution showed that low PsbO plants had a reduced quantum yield, but matched the oxygen evolution rates of WT plants at saturating irradiance.	Oxygen	42-48	PS II oxygen-evolving complex 1	Arabidopsis thaliana	75-79
16821877-2	2006	Additionally, the SPR band showed no measurable signal change upon exposure to CO at temperatures below approximately 400 degrees C. The oxygen and temperature-dependent characteristics, coupled with the oxygen ion formation and conduction properties of the YSZ matrix, are indicative of charge-transfer reactions occurring at the three-phase boundary region between oxygen, Au, and YSZ, which result in charge transfer into the Au nanoparticles.	Oxygen	137-143	sepiapterin reductase	Homo sapiens	18-21
16388825-11	2006	This study also shows that under the steady-state conditions the effect of myoglobin (Mb) on oxygen transport was small.	Oxygen	93-99	myoglobin	Rattus norvegicus	75-84
16388825-11	2006	This study also shows that under the steady-state conditions the effect of myoglobin (Mb) on oxygen transport was small.	Oxygen	93-99	myoglobin	Rattus norvegicus	86-88
12641451-4	2003	In the structure of the cathepsin S-aldehyde complex, the tetrahedral thiohemiacetal adduct favors the S-configuration, in which the oxygen atom interacts with the imidazole group of the active site His164 rather than with the oxyanion hole.	Oxygen	133-139	cathepsin S	Homo sapiens	24-35
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	Oxygen	72-78	APC regulator of WNT signaling pathway	Homo sapiens	298-301
12573436-0	2003	The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer.	Oxygen	66-72	von Hippel-Lindau tumor suppressor	Homo sapiens	4-38
12573436-1	2003	The von Hippel-Lindau tumor suppressor protein (pVHL) is the substrate-recognition module of an E3 ubiquitin ligase that targets the alpha subunits of hypoxia-inducible factor (HIF) for degradation in the presence of oxygen.	Oxygen	217-223	von Hippel-Lindau tumor suppressor	Homo sapiens	4-38
12573436-1	2003	The von Hippel-Lindau tumor suppressor protein (pVHL) is the substrate-recognition module of an E3 ubiquitin ligase that targets the alpha subunits of hypoxia-inducible factor (HIF) for degradation in the presence of oxygen.	Oxygen	217-223	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
16848409-0	2006	Synthesis and active oxygen generation by new emodin derivatives and their gonadotropin-releasing hormone conjugates.	Oxygen	21-27	gonadotropin releasing hormone 1	Homo sapiens	75-105
16787441-4	2006	Here we show that hypoxia (1% oxygen) reduces the expression levels of heme oxygenase-2 mRNA and protein after 48 h of incubation in human cell lines, including Jurkat T-lymphocytes, YN-1 and K562 erythroleukemia, HeLa cervical cancer, and HepG2 hepatoma, as judged by northern blot and western blot analyses.	Oxygen	30-36	heme oxygenase 2	Homo sapiens	71-87
22922640-8	2012	The irradiance response of photosynthetic oxygen evolution showed that low PsbO plants had a reduced quantum yield, but matched the oxygen evolution rates of WT plants at saturating irradiance.	Oxygen	132-138	PS II oxygen-evolving complex 1	Arabidopsis thaliana	75-79
22027852-1	2012	The purpose of this study was to investigate the main bioenergetics and neuromuscular determinants of the time to exhaustion (T(lim)) at the velocity corresponding to maximal oxygen uptake in recreational long-distance runners.	Oxygen	175-181	PDZ and LIM domain 5	Homo sapiens	128-131
16809770-0	2006	5"-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.	Oxygen	57-63	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	33-37
12785056-10	2003	The various functions of oxygen, e.g. (1) quenching of the triplet state; (2) quenching of the semiquinone radical, thereby forming HO2*/O2*- radicals; and (3) trapping of the dihydroxyanthracenes are outlined.	Oxygen	25-31	heme oxygenase 2	Homo sapiens	132-135
22714897-1	2012	PURPOSE: The goal of our study was to evaluate the in vitro and in vivo anti-angiogenic effects of ERbeta selective agonist, beta-LGND2, using human retinal microvascular endothelial cell (HRMVEC) cultures and a mouse model for oxygen-induced retinopathy (OIR).	Oxygen	228-234	estrogen receptor 2	Homo sapiens	99-105
16706650-1	2006	A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the terminal oxidases.	Oxygen	250-256	tripartite motif containing 33	Homo sapiens	38-42
16706650-1	2006	A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the terminal oxidases.	Oxygen	250-256	tripartite motif containing 33	Homo sapiens	286-290
16678800-3	2006	Recently, we demonstrated that AMP-activated protein kinase (AMPK), which acts as an energy sensor, providing metabolic adaptation effects under ATP-deprived conditions, is critical for the expression of VEGF under oxygen- and glucose-deprived conditions.	Oxygen	215-221	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	31-59
16678800-3	2006	Recently, we demonstrated that AMP-activated protein kinase (AMPK), which acts as an energy sensor, providing metabolic adaptation effects under ATP-deprived conditions, is critical for the expression of VEGF under oxygen- and glucose-deprived conditions.	Oxygen	215-221	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
22429303-2	2012	Such oxygen atoms may be part of one or two charged oxyanions, which means that Mg2+ can, for instance, tie together two different phosphate groups that are located at distance from each other in a macromolecule, and in this way be responsible for the folding of molecules like RNA.	Oxygen	5-11	mucin 7, secreted	Homo sapiens	80-83
16714552-6	2006	Second, cultivation at human bloodstream oxygen concentration (5% relative to 21% atmospheric) significantly decreases the transcript quantity of all hbp genes, indicating that expression is influenced by O2 and/or reactive oxygen species.	Oxygen	41-47	heme binding protein 1	Homo sapiens	150-153
16714552-6	2006	Second, cultivation at human bloodstream oxygen concentration (5% relative to 21% atmospheric) significantly decreases the transcript quantity of all hbp genes, indicating that expression is influenced by O2 and/or reactive oxygen species.	Oxygen	205-207	heme binding protein 1	Homo sapiens	150-153
26105262-11	2012	CTC: single mt O2 consumption (obtained by normalizing data both by CS activity and mtDNA) was slightly increased both in PE and IUGR.	Oxygen	15-17	citrate synthase	Homo sapiens	68-70
16484344-8	2006	Furthermore, NPC2 protein upregulates hypoxia inducible factor 1-alpha protein level at 7% O(2), but not at 20% O(2).	Oxygen	91-95	NPC intracellular cholesterol transporter 2	Homo sapiens	13-17
16484344-9	2006	Our results demonstrate that NPC2 protein plays a role in hematopoiesis at the physiologic bone marrow level of O(2).	Oxygen	112-116	NPC intracellular cholesterol transporter 2	Homo sapiens	29-33
22612449-6	2012	In contrast to the classical reductive SMSI in the TiO(2) supported group VIII metals which appears after high temperature reduction in H(2) with electron transfer from the support to metals, the oxidative SMSI in Au/ZnO-nanorod system gives oxygen-induced burial and electron transfer from gold to support.	Oxygen	242-248	cytochrome c oxidase subunit 8A	Homo sapiens	74-78
16700547-4	2006	It is believed that DHC is the electron donor for SHP, which is known to bind oxygen.	Oxygen	78-84	nuclear receptor subfamily 0 group B member 2	Homo sapiens	50-53
22568496-0	2012	Microarray of human P450 with an integrated oxygen sensing film for high-throughput detection of metabolic activities.	Oxygen	44-50	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	20-24
16537100-3	2006	Cx43 is involved in cardiomyocyte free oxygen radical formation and in the cardioprotection by ischemic preconditioning (IP).	Oxygen	39-45	gap junction protein alpha 1	Homo sapiens	0-4
22568496-6	2012	By normalizing the responses with the amounts of oxygen sensor and P450 enzymes in microwells, we could obtain fluorescence enhancement patterns that were characteristic to the combination of P450 isoforms and substrate material.	Oxygen	49-55	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	192-196
25657662-3	2012	Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria.	Oxygen	68-74	cytochrome c	Oryctolagus cuniculus	136-148
16817867-5	2006	The results show that ChT, IL-16 and O2(-) levels significantly increased in ischemic CvD patients compared with AD patients and were significantly and positively correlated with IL-18 and O2(-).	Oxygen	189-191	interleukin 16	Homo sapiens	27-32
16506866-3	2006	The quantum yield of oxygen uptake (Phi(-O(2))) increases with increasing 2-propanol concentration up to 0.9.	Oxygen	21-27	glucose-6-phosphate isomerase	Homo sapiens	36-39
16500017-9	2006	There was an oxygen-dependent increase in global cerebral activity of matrix metalloproteinase-2 with specific increases in the basal ganglia of all hypoxic-reoxygenated brains.	Oxygen	13-19	matrix metallopeptidase 2	Homo sapiens	70-96
16500017-11	2006	CONCLUSIONS: Although using high oxygen concentration to resuscitate asphyxiated newborn piglets increased carotid vascular resistance and cerebral matrix metalloproteinase-2 activity, there is no detrimental effect observed in this acute model of hypoxia-reoxygenation.	Oxygen	33-39	matrix metallopeptidase 2	Homo sapiens	148-174
22503847-12	2012	Compared with the control group, the p38alpha shRNA group showed a higher pulmonary vein oxygen level, lower wet weight-to-dry weight ratio, lower lung injury score, and lower serum levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-8.	Oxygen	89-95	mitogen activated protein kinase 14	Rattus norvegicus	37-45
16688111-12	2006	COX-2 protects retinal vessels from thrombosis, limiting the area of retinal nonperfusion in oxygen-induced retinopathy.	Oxygen	93-99	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
16611807-2	2006	We show that the COMT Met158 allele and the DAT 3" variable number of tandem repeat 10-repeat allele are independently associated in healthy humans with more focused neuronal activity (as measured with blood oxygen level-dependent functional magnetic resonance imaging) in the working memory cortical network, including the prefrontal cortex.	Oxygen	208-214	catechol-O-methyltransferase	Homo sapiens	17-21
22389426-11	2012	The results indicate that PACAP causes transactivation of the EGFR in NSCLC cells in an oxygen-dependent manner that involves phospholipase C but not protein kinase A.	Oxygen	88-94	adenylate cyclase activating polypeptide 1	Homo sapiens	26-31
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Oxygen	31-33	DNA polymerase iota	Homo sapiens	121-125
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Oxygen	31-33	DNA polymerase iota	Homo sapiens	126-130
22741033-0	2012	A Prominin-1-Rich Pediatric Glioblastoma: Biologic Behavior Is Determined by Oxygen Tension-Modulated CD133 Expression but Not Accompanied by Underlying Molecular Profiles.	Oxygen	77-83	prominin 1	Homo sapiens	102-107
16608165-6	2006	Use of 18O-labeled oxygen under controlled atmospheres confirmed an oxidative mechanism in the P450-mediated deboronation of 1, as 18O was found incorporated in both M1 and M2.	Oxygen	19-25	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	95-99
22741033-11	2012	Furthermore, our research documents a direct link between decreasing oxygen tension and CD133 expression.	Oxygen	69-75	prominin 1	Homo sapiens	88-93
21875341-6	2012	After 3 days in suspension culture as embryoid bodies (EBs), 2% O(2) caused the activation of hypoxia inducible factor responsive genes VEGF and LDHA and was accompanied by elevated expression levels of the early eye field genes Six3 and Lhx2.	Oxygen	64-68	LIM homeobox 2	Homo sapiens	238-242
22406000-3	2012	This review"s focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis.	Oxygen	85-91	von Hippel-Lindau tumor suppressor	Homo sapiens	30-47
16384869-5	2006	We also examined EG-VEGF and PKR1 regulation by oxygen tension in isolated trophoblast cells (TCs).	Oxygen	48-54	prokineticin receptor 1	Homo sapiens	29-33
16552061-10	2006	The hlyB and hlyA genes are organized in an operon that is coordinately regulated by iron and oxygen.	Oxygen	94-100	hemolysin transport protein	Escherichia coli	13-17
16552061-15	2006	Moreover, the expression levels of hlyBA and hlyA were reduced about threefold following oxygen exposure and treatment with hydrogen peroxide.	Oxygen	89-95	hemolysin transport protein	Escherichia coli	45-49
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c oxidase subunit 8A	Homo sapiens	41-44
16525714-3	2006	The effect of ectopic protein expression on liver energy metabolism, which was evaluated 42 h after DNA transfer, showed that mitochondria expressing UCP1 presented decreased ATP production, lasted more time in membrane potential state 3, and consumed more molecular oxygen to produce the same amount of ATP than the control group.	Oxygen	267-273	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	150-154
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Oxygen	13-15	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
22311417-7	2012	Mitochondrial uncoupling was partly inhibited by the UCP inhibitor GDP (-1.1 +- 0.1 pmol O(2) s(-1) [mg protein](-1)).	Oxygen	89-95	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	53-56
16624394-4	2006	Intracerebroventricular (ICV) injection of TRH (14 and 55 nmol) dose-dependently increased oxygen consumption, carbon dioxide production and HP, and a similar effect was also observed with CRF (2.1 and 21 pmol).	Oxygen	91-97	thyrotropin releasing hormone	Homo sapiens	43-46
22294260-11	2012	These data provide first evidence that AEC and VEC from the same vascular loop respond differently to ECM and oxygen in a Fak-dependent manner.	Oxygen	110-116	protein tyrosine kinase 2	Homo sapiens	122-125
16565424-5	2006	The circulating RBC is a major SNO reservoir, and RBC Hb releases SNO-related bioactivity peripherally on O2 desaturation.	Oxygen	106-108	strawberry notch homolog 1	Homo sapiens	66-69
12517389-3	2003	Supplementation of the medium 24h post insemination with TRX significantly (P&lt;0.05) enhanced the frequency of development to the blastocyst stage in 5% O(2) concentration.	Oxygen	155-159	thioredoxin	Bos taurus	57-60
12517389-7	2003	However, a preincubation of TRX in the culture medium under 20% oxygen for 24h did not diminish the promoting effect in the subsequent TRX treatment under optimal conditions, thus suggesting that the possible oxidation of TRX alone may not be the reason for the disappearance of the effect under a high oxygen concentration.	Oxygen	64-70	thioredoxin	Bos taurus	28-31
12650521-1	2003	Although the 150 kDa oxygen-regulated protein (ORP150) is known as a protein induced by low oxygen tension or ischemical insult, its possible role has not been fully investigated in vivo.	Oxygen	21-27	hypoxia up-regulated 1	Mus musculus	47-53
12522074-1	2003	1 When nitric oxide synthase (NOS) produces NO from N(G)-hydroxy-L-arginine (OH-arginine) instead of L-arginine, the total requirement of molecular oxygen and NADPH to form NO is reduced.	Oxygen	148-154	nitric oxide synthase, brain	Oryctolagus cuniculus	7-28
16499351-1	2006	The reaction of LAl[eta2-(C2(SiMe3)2)] (1; L = HC[(CMe)(NDipp)]2, Dipp = 2,6-iPr2C6H3) with dioxygen leads to the elimination of bis(trimethylsilyl)acetylene and the formation of the corresponding aluminum monohydroxide via the oxidation of one of the CHMe2 groups on the Dipp ring.	Oxygen	92-100	lipase A, lysosomal acid type	Homo sapiens	16-19
22387164-6	2012	CoQ(2) (23 muM) reduced the respiratory control index by 32% and 57% (p&lt;0.01) in heart and liver mitochondria respectively, mainly through an increased oxygen consumption in state 4.	Oxygen	155-161	coenzyme Q2, polyprenyltransferase	Rattus norvegicus	0-6
12937836-4	2003	Presented study investigates the effects of oxygen tension on CA IX expression in HeLa cell culture.	Oxygen	44-50	carbonic anhydrase 9	Homo sapiens	62-67
12937836-8	2003	Both approaches completely abrogated CA IX expression in dense HeLa cell cultures and therefore confirmed the importance of decreased oxygen tension in high cell density-induced CA IX expression.	Oxygen	134-140	carbonic anhydrase 9	Homo sapiens	178-183
12937836-9	2003	In addition, HeLa cells exposed to hyperoxia retained inducibility of CAIX expression by transition metals and iron chelators, suggesting that they act independently of cell density mediated-pO2-gradient or at a downstream site from oxygen sensor.	Oxygen	233-239	carbonic anhydrase 9	Homo sapiens	70-74
22516907-9	2012	This study shows that both V1 and V2 are appropriate techniques for optimizing O2-cost on moderate to steep inclines in elite skiers.	Oxygen	79-81	immunoglobulin kappa variable 1-5	Homo sapiens	27-36
12456885-3	2002	Although genetic studies with mutants deficient in SOD1, the predominantly cytosolic isoform of SOD, have been instrumental in elucidating the role of reactive oxygen metabolism in aging in Drosophila, the lack of available mutations in the Sod2 gene has hampered an equivalent analysis of the participation of this important antioxidant enzyme in the Drosophila aging model.	Oxygen	160-166	Superoxide dismutase 1	Drosophila melanogaster	51-55
12456885-3	2002	Although genetic studies with mutants deficient in SOD1, the predominantly cytosolic isoform of SOD, have been instrumental in elucidating the role of reactive oxygen metabolism in aging in Drosophila, the lack of available mutations in the Sod2 gene has hampered an equivalent analysis of the participation of this important antioxidant enzyme in the Drosophila aging model.	Oxygen	160-166	Superoxide dismutase 1	Drosophila melanogaster	51-54
22387751-6	2012	Intriguingly, Norrin promotes vessel regrowth and induces the formation of intraretinal capillaries following oxygen-induced retinopathy in mice, an animal model of retinopathy of prematurity.	Oxygen	110-116	Norrie disease (pseudoglioma) (human)	Mus musculus	14-20
12530625-0	2002	The role of myoglobin in retarding oxygen depletion in anoxic heart.	Oxygen	35-41	myoglobin	Rattus norvegicus	12-21
12530625-7	2002	When the oxygen-binding function of Mb, in situ in the heart, is abolished by treatment with sodium nitrite (NaNO2), the redox kinetics of cytaa3 show significant perturbations.	Oxygen	9-15	myoglobin	Rattus norvegicus	36-38
12530625-12	2002	We conclude from these results that Mb may support mitochondrial respiration at the critical levels of the myocardial O2 supply.	Oxygen	118-120	myoglobin	Rattus norvegicus	36-38
22408005-4	2012	METHODS: The expression and effect of ephrin-A4 was investigated in a mouse model of oxygen-induced retinopathy (OIR) and the RF/6A retina endothelial cell line.	Oxygen	85-91	ephrin A4	Mus musculus	38-47
12427234-0	2002	Neuropeptide Y expression in a mouse model of oxygen-induced retinopathy.	Oxygen	46-52	neuropeptide Y	Mus musculus	0-14
12427234-2	2002	The goal of this study was to determine the expression of NPY and its receptors, NPY Y1 and NPY Y2, in a mouse model of oxygen-induced retinopathy.	Oxygen	120-126	neuropeptide Y	Mus musculus	58-61
12427234-2	2002	The goal of this study was to determine the expression of NPY and its receptors, NPY Y1 and NPY Y2, in a mouse model of oxygen-induced retinopathy.	Oxygen	120-126	neuropeptide Y	Mus musculus	81-84
22343635-1	2012	Fumarate reductase is a protein involved in the maintenance of redox balance during oxygen deficiency.	Oxygen	84-90	fumarate reductase	Saccharomyces cerevisiae S288C	0-18
12427234-2	2002	The goal of this study was to determine the expression of NPY and its receptors, NPY Y1 and NPY Y2, in a mouse model of oxygen-induced retinopathy.	Oxygen	120-126	neuropeptide Y	Mus musculus	81-84
12427234-5	2002	RESULTS: Retinal NPY mRNA expression was increased by 2.3-fold from P7 to P12, and 2.8-fold from P7 to P17 in oxygen-reared animals.	Oxygen	110-116	neuropeptide Y	Mus musculus	17-20
12427234-8	2002	Retinal NPY Y2 expression in oxygen-reared animals increased by 2.8-fold from P7 to P12 and by 2.7-fold from P12 to P17.	Oxygen	29-35	neuropeptide Y	Mus musculus	8-11
12427234-8	2002	Retinal NPY Y2 expression in oxygen-reared animals increased by 2.8-fold from P7 to P12 and by 2.7-fold from P12 to P17.	Oxygen	29-35	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	84-87
12427234-8	2002	Retinal NPY Y2 expression in oxygen-reared animals increased by 2.8-fold from P7 to P12 and by 2.7-fold from P12 to P17.	Oxygen	29-35	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	109-112
12427234-12	2002	CONCLUSIONS: Retinal NPY and NPY Y2 receptor expression are altered in the development of oxygen-induced retinopathy of the mouse, during both the hyperoxic vasoconstrictive phase and the period of retinal neovascularization.	Oxygen	90-96	neuropeptide Y	Mus musculus	21-24
12443749-1	2002	OBJECTIVE: to identify whether monitoring transcutaneous oxygen pressure (TcpO(2)) can provide an objective method of assessing the results of PTA.	Oxygen	57-63	pre T cell antigen receptor alpha	Homo sapiens	143-146
12553559-1	2002	Human spermatozoa are more dependent on glutathione peroxidase/glutathione reductase (GPX/GR) system, via reduced glutathione (GSH), to inactivate reactive oxygen metabolites (ROMs) such as hydrogen peroxide and organic hydroperoxides.	Oxygen	156-162	glutathione-disulfide reductase	Homo sapiens	63-84
12215449-3	2002	The female rats that had greater oxygen consumption showed higher UCP1 content, a higher multilocular arrangement, and both longer cristae and higher cristae dense mitochondria in BAT indicating heightened thermogenic capacity and activity; this picture is accompanied by a more sensitive beta(3)-AR to norepinephrine signal (EC(50) 10-fold lower for CGP12177A) and a lower expression of alpha(2A)-AR than male rats.	Oxygen	33-39	adrenoceptor alpha 2A	Rattus norvegicus	388-400
12384962-6	2002	The gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine biosynthesis, is regulated by hypoxia in the CB and in the oxygen-sensitive cultured PC12 cell line.	Oxygen	152-158	tyrosine hydroxylase	Rattus norvegicus	23-43
12384962-6	2002	The gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine biosynthesis, is regulated by hypoxia in the CB and in the oxygen-sensitive cultured PC12 cell line.	Oxygen	152-158	tyrosine hydroxylase	Rattus norvegicus	45-47
12674643-2	2002	The results indicate that keeping dissolved oxygen at 40% and controlling nutrient feeding rate with DO feed back strategy can obtain theoretically 3.59 g recombinant mature peptide of hBMP-2 per liter of broth, the final cell density OD600 reaches 57(22.8 g dry cell weight/L), and the expression of rhBMP-2 amounts to 30% of the total protein in E. coli.	Oxygen	44-50	bone morphogenetic protein 2	Homo sapiens	185-191
12370842-1	2002	The purpose of the present study was to investigate the relationships among the resting systolic (SBP) and diastolic blood pressure (DBP) or SBP response during exercise with insulin resistance evaluated by a homeostasis model (HOMA-IR), abdominal fat accumulation (visceral fat area [VFA], subcutaneous fat area [SFA]) by computed tomography (CT), and an estimation of the maximal oxygen uptake (V*O2max) in 63 Japanese middle-aged male patients with type 2 diabetes mellitus (type 2 DM).	Oxygen	382-388	selenium binding protein 1	Homo sapiens	98-101
12239351-6	2002	Subretinal transplantation of PEDF expressing IPE cells inhibited pathological choroidal neovascularization in rat models of laser-induced rupture of Bruch"s membrane and of oxygen induced ischemic retinopathy.	Oxygen	174-180	serpin family F member 1	Rattus norvegicus	30-34
12209156-2	2002	The unusual clinical features of this disorder predicted a role for the von Hippel-Lindau gene (VHL) in the oxygen-sensing pathway.	Oxygen	108-114	von Hippel-Lindau tumor suppressor	Homo sapiens	96-99
12204502-6	2002	RESULTS: In patients with chronic HF, BNP levels correlated with oxygen uptake (VO(2)), both at anaerobic threshold (VO(2)AT: r = -0.54, p &lt; 0.001) and peak exercise (peak VO(2): r = -0.56, p &lt; 0.001).	Oxygen	65-71	natriuretic peptide B	Homo sapiens	38-41
21708785-5	2002	We show that oxygen consumption rate is correlated with the activity of key metabolic enzymes (e.g., citrate synthase and malate dehydrogenase) for some intertidal species, and concentrations of these enzymes in certain tissues are lower for starved individuals than for those that are well fed.	Oxygen	13-19	citrate synthase	Homo sapiens	101-117
12095541-1	2002	Endothelin-1 (ET-1) is a putative messenger of oxygen in the ductus arteriosus.	Oxygen	47-53	EDN1	Ovis aries	0-12
12095541-1	2002	Endothelin-1 (ET-1) is a putative messenger of oxygen in the ductus arteriosus.	Oxygen	47-53	EDN1	Ovis aries	14-18
12095541-10	2002	Hence, the concept of ET-1 mediating the oxygen contraction is further validated.	Oxygen	41-47	EDN1	Ovis aries	22-26
12099689-3	2002	We further investigated the effect of NO on the binding activity of the von Hippel-Lindau tumor suppressor protein (pVHL) to the N-terminal activation domain (NAD) overlapping the oxygen-dependent degradation domain (ODD) of HIF-1alpha, because this reaction involves prolyl hydroxylation in NAD that requires oxygen.	Oxygen	180-186	von Hippel-Lindau tumor suppressor	Homo sapiens	116-120
12099689-3	2002	We further investigated the effect of NO on the binding activity of the von Hippel-Lindau tumor suppressor protein (pVHL) to the N-terminal activation domain (NAD) overlapping the oxygen-dependent degradation domain (ODD) of HIF-1alpha, because this reaction involves prolyl hydroxylation in NAD that requires oxygen.	Oxygen	310-316	von Hippel-Lindau tumor suppressor	Homo sapiens	116-120
12100171-9	2002	Analysis of the effect of Nix-0699 on the Hb S oxygen affinity indicated that the drug slightly shifted the oxygen-dissociation curve of Hb S toward the left without any apparent change in the Hill coefficient.	Oxygen	47-53	BCL2 interacting protein 3 like	Homo sapiens	26-29
12100171-9	2002	Analysis of the effect of Nix-0699 on the Hb S oxygen affinity indicated that the drug slightly shifted the oxygen-dissociation curve of Hb S toward the left without any apparent change in the Hill coefficient.	Oxygen	108-114	BCL2 interacting protein 3 like	Homo sapiens	26-29
12039855-8	2002	Wt1 expression in the coronary vessels of the ischemic heart was mimicked by exposure of rats to normobaric hypoxia (8% O2) and 0.1% CO, respectively.	Oxygen	120-122	WT1 transcription factor	Rattus norvegicus	0-3
12065837-2	2002	Plant response to oxygen deprivation involves increased expression of the alcohol dehydrogenase gene (ADH) and ethanolic fermentation.	Oxygen	18-24	alcohol dehydrogenase 1	Arabidopsis thaliana	74-95
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Oxygen	211-217	Mga2p	Saccharomyces cerevisiae S288C	274-279
12109881-1	2002	After isolation from a pulp mill wastewater treatment facility, two yeast strains, designated SPT1 and SPT2, were characterized and used in the development of mediated biochemical oxygen demand (BOD) biosensors for wastewater.	Oxygen	180-186	Spt2p	Saccharomyces cerevisiae S288C	103-107
12062208-9	2002	P(4)Hb hyperpolymers (the high molecular moiety of P(4)Hb) are suitable for an oxygen-carrying blood additive: their oxygen-binding properties are sufficient, they are fully compatible with human blood plasma, and at the intended therapeutic concentration of approximately 30 g/l oncotic pressures are very low, and the impact on blood viscosity is tolerable.	Oxygen	79-85	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-6
12062208-9	2002	P(4)Hb hyperpolymers (the high molecular moiety of P(4)Hb) are suitable for an oxygen-carrying blood additive: their oxygen-binding properties are sufficient, they are fully compatible with human blood plasma, and at the intended therapeutic concentration of approximately 30 g/l oncotic pressures are very low, and the impact on blood viscosity is tolerable.	Oxygen	79-85	prolyl 4-hydroxylase subunit beta	Homo sapiens	51-57
12062208-9	2002	P(4)Hb hyperpolymers (the high molecular moiety of P(4)Hb) are suitable for an oxygen-carrying blood additive: their oxygen-binding properties are sufficient, they are fully compatible with human blood plasma, and at the intended therapeutic concentration of approximately 30 g/l oncotic pressures are very low, and the impact on blood viscosity is tolerable.	Oxygen	117-123	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-6
12062208-9	2002	P(4)Hb hyperpolymers (the high molecular moiety of P(4)Hb) are suitable for an oxygen-carrying blood additive: their oxygen-binding properties are sufficient, they are fully compatible with human blood plasma, and at the intended therapeutic concentration of approximately 30 g/l oncotic pressures are very low, and the impact on blood viscosity is tolerable.	Oxygen	117-123	prolyl 4-hydroxylase subunit beta	Homo sapiens	51-57
11880309-8	2002	In another model of subacute injury, serum SP-D was increased in rats treated with paraquat plus oxygen.	Oxygen	97-103	surfactant protein D	Rattus norvegicus	43-47
11940759-7	2002	Apart from higher oxygen consumption in the group receiving 3000 units of MnSOD 24 hrs after smoke inhalation (263 +/- 44 mL/min vs. 182 +/- 36 mL/min; p &lt; 0.05), no significant differences between treatment groups and control group were observed.	Oxygen	18-24	superoxide dismutase [Mn], mitochondrial	Gossypium hirsutum	74-79
11909946-3	2002	Here we describe evidence obtained by using wild-type and HIF-1 alpha nullizygous mouse embryonic fibroblasts (mEFs) that the induction of c-jun mRNA expression and c-Jun phosphorylation by prolonged hypoxia are completely dependent on the presence of the oxygen-regulated transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha).	Oxygen	256-262	jun proto-oncogene	Mus musculus	139-144
16537890-0	2006	Gender and COPD in patients with chronic respiratory insufficiency requiring domiciliary oxygen therapy.	Oxygen	89-95	COPD	Homo sapiens	11-15
16492977-0	2006	Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air.	Oxygen	22-28	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	0-4
16492977-6	2006	A profound decrease of lgl1 expression with oxygen exposure was observed in both animal models.	Oxygen	44-50	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	23-27
16492977-7	2006	Animals exposed to 95% O2 for 1 wk recovered in air over a 3-wk period, associated with normalization of lgl1 levels.	Oxygen	23-25	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	105-109
16435814-0	2006	Quantum mechanical rate constants for H + O2 &lt;--&gt; O + OH and H + O2 --&gt; HO2 reactions.	Oxygen	42-44	heme oxygenase 2	Homo sapiens	81-84
16912429-1	2006	In the present report we have shown that bovine articular chondrocytes cultured in low oxygen tension, i.e. in conditions mimicking their hypoxic in vivo environment, respond to IL-1beta (10 ng/ml) by an increased DNA binding activity of NF-kappaB and AP-l transcription factors.	Oxygen	87-93	interleukin 1 beta	Bos taurus	178-186
16912429-5	2006	Rhein was capable of reducing the IL-1beta-stimulated ERK1/ERK2 pathway whatever the tension of oxygen present in the environment.	Oxygen	96-102	interleukin 1 beta	Bos taurus	34-42
16542504-9	2006	MCP-1 production was associated with postoperative thrombocytopenia, and MIF was related to the use of a high dose of vasopressors in patients with cardiovascular impairment and also to lower values of the ratio of partial arterial oxygen tension (PaO2) to fraction of inspired oxygen (FiO2) registered in the first 24 hours after CPB.	Oxygen	232-238	macrophage migration inhibitory factor	Homo sapiens	73-76
16247826-6	2005	The latter results are rationalized by the formation of an undetectable amount of 2 from the reaction of 1 and ArI through equilibrium that leads to a fast oxygen exchange between 2 and H(2)18O.	Oxygen	156-162	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	111-114
16324151-1	2005	The superoxide-producing NAD(P)H oxidase Nox4 was initially identified as an enzyme that is highly expressed in the kidney and is possibly involved in oxygen sensing and cellular senescence.	Oxygen	151-157	NADPH oxidase 4	Homo sapiens	41-45
16299171-1	2005	The alternative oxidase (AOX) of plant mitochondria transfers electrons from the ubiquinone pool to oxygen without energy conservation.	Oxygen	100-106	alternative oxidase 2	Arabidopsis thaliana	4-23
16299171-1	2005	The alternative oxidase (AOX) of plant mitochondria transfers electrons from the ubiquinone pool to oxygen without energy conservation.	Oxygen	100-106	alternative oxidase 2	Arabidopsis thaliana	25-28
16511222-1	2005	Cysteine dioxygenase (CDO; EC 1.13.11.20) is an approximately 23 kDa non-heme iron metalloenzyme that is responsible for the oxidation of cysteine by O2, yielding cysteinesulfinate.	Oxygen	150-152	cysteine dioxygenase type 1	Rattus norvegicus	22-25
16249674-8	2005	Compared with control, G-CSF increased airway pressures with high tidal volumes and worsened lung edema and arterial oxygen with both tidal volumes (P &lt; 0.05 for each).	Oxygen	117-123	colony stimulating factor 3	Rattus norvegicus	23-28
16037395-1	2005	Twenty-one subjects with asthma underwent treadmill exercise to exhaustion at a workload that elicited approximately 90% of each subject"s maximal O2 uptake (EX1).	Oxygen	147-149	FERM domain containing 6	Homo sapiens	158-161
15988767-0	2005	Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions.	Oxygen	65-71	arginine deiminase	Escherichia coli	10-14
16100226-2	2005	The amount of glycine decarboxylase in the bundle sheath (BS) varies among C4 grasses and is positively correlated with the granal index (ratio of the length of appressed thylakoid membranes to the total length of all thylakoid membranes) of the BS chloroplasts: C4 grasses with high granal index contained more glycine decarboxylase per unit leaf area than those with low granal index, probably reflecting the differences in O2 production from photosystem II and the potential photorespiratory capacity.	Oxygen	426-428	glycine decarboxylase	Homo sapiens	14-35
16234850-6	2005	A database search for proteins potentially regulated by oxygen tension revealed that ALAS2 contained a sequence of amino acids (LXXLAP where L is leucine, X is any amino acid, A is alanine, and P is proline) not occurring in ALAS1, which may be hydroxylated under normoxic conditions (21% O2) and target the enzyme for ubiquitination and degradation by the proteasome.	Oxygen	56-62	5'-aminolevulinate synthase 2	Homo sapiens	85-90
16234850-6	2005	A database search for proteins potentially regulated by oxygen tension revealed that ALAS2 contained a sequence of amino acids (LXXLAP where L is leucine, X is any amino acid, A is alanine, and P is proline) not occurring in ALAS1, which may be hydroxylated under normoxic conditions (21% O2) and target the enzyme for ubiquitination and degradation by the proteasome.	Oxygen	289-291	5'-aminolevulinate synthase 2	Homo sapiens	85-90
16234850-8	2005	Normoxic ALAS2 had a turnover time of approximately 36 h. Hypoxia (1% O2) and inhibition of the proteasome increased both the stability and the specific activity of ALAS2 (greater than 2- and 7-fold, respectively, over 72 h of treatment).	Oxygen	70-72	5'-aminolevulinate synthase 2	Homo sapiens	9-14
16234850-8	2005	Normoxic ALAS2 had a turnover time of approximately 36 h. Hypoxia (1% O2) and inhibition of the proteasome increased both the stability and the specific activity of ALAS2 (greater than 2- and 7-fold, respectively, over 72 h of treatment).	Oxygen	70-72	5'-aminolevulinate synthase 2	Homo sapiens	165-170
16139272-3	2005	Nitration and phosphorylation of ERK1/2 by Ang II was significantly inhibited by NAD(P)H inhibitors and scavengers of oxygen and nitrogen reactive species and completely blocked by a selective inducible nitric-oxide synthase inhibitor.	Oxygen	118-124	mitogen activated protein kinase 3	Rattus norvegicus	33-39
15918795-4	2005	In the present study, we report on the activation of the JAK2/STAT5 pathway (where JAK stands for Janus kinase and STAT stands for signal transduction and activator of transcription) by low oxygen in microvascular endothelial cells.	Oxygen	190-196	Janus kinase 2	Homo sapiens	57-61
22515798-1	2012	OBJECTIVES: This study aims to examine amplitude changes of low-frequency oscillations (fALFF) in the blood-oxygen level-dependent (BOLD) signal associated with acupuncture on NeiGuan (PC6).	Oxygen	108-114	proprotein convertase subtilisin/kexin type 5	Homo sapiens	185-188
16086306-8	2005	Furthermore, pharmacologic inhibition of MMP-2 activity in fetal lung explants cultured at 21% O(2) resulted in increased TN-C deposition within the mesenchyme, as well as enhanced branching morphogenesis.	Oxygen	95-99	matrix metallopeptidase 2	Rattus norvegicus	41-46
22527961-0	2012	Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).	Oxygen	26-32	Janus kinase 2	Homo sapiens	124-138
15988760-7	2005	In addition, exposure to hypoxic conditions resulted in diminished angiogenin secretion in the presence of both ECMs suggesting that angiogenin expression in the presence of ECM is modulated by local O2 concentration.	Oxygen	200-202	angiogenin	Homo sapiens	67-77
15988760-7	2005	In addition, exposure to hypoxic conditions resulted in diminished angiogenin secretion in the presence of both ECMs suggesting that angiogenin expression in the presence of ECM is modulated by local O2 concentration.	Oxygen	200-202	angiogenin	Homo sapiens	133-143
16389727-6	2005	Exposure of FHRs to 4 weeks of 10% O2 (hypoxia) significantly attenuated the effect of both forskolin (n = 7) and CPT-cAMP (n = 14) on BKCa channel activity in PASMC.	Oxygen	35-37	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	135-139
16148071-7	2005	In pulmonary tissue, pro- and active MMP-2 levels were increased in piglets that were resuscitated with 100% O2 compared with 21% O2.	Oxygen	109-111	matrix metallopeptidase 2	Homo sapiens	37-42
16148071-7	2005	In pulmonary tissue, pro- and active MMP-2 levels were increased in piglets that were resuscitated with 100% O2 compared with 21% O2.	Oxygen	130-132	matrix metallopeptidase 2	Homo sapiens	37-42
16148071-11	2005	In BAL fluid, both pro-MMP-9 and pro-MMP-2 increased 2-fold in the 100% O2 group compared with 21% O2.	Oxygen	72-74	matrix metallopeptidase 2	Homo sapiens	37-42
22527961-0	2012	Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).	Oxygen	26-32	Janus kinase 2	Homo sapiens	140-144
15778277-0	2005	gp91phox-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II.	Oxygen	105-111	cytochrome b-245, beta polypeptide	Mus musculus	0-8
22800456-0	2012	[Variation of expression of Pyk2 in oxygen-induced retinal neovascularization mice model].	Oxygen	36-42	PTK2 protein tyrosine kinase 2 beta	Mus musculus	28-32
15963939-3	2005	Using (6R)-tetrahydrobiopterin as electron donor in the phenylalanine hydroxylase (PAH) reaction, a stable stoichiometry of 1:1 was obtained between the amount of oxygen consumed and the tyrosine formation.	Oxygen	163-169	phenylalanine hydroxylase	Homo sapiens	56-81
15963939-3	2005	Using (6R)-tetrahydrobiopterin as electron donor in the phenylalanine hydroxylase (PAH) reaction, a stable stoichiometry of 1:1 was obtained between the amount of oxygen consumed and the tyrosine formation.	Oxygen	163-169	phenylalanine hydroxylase	Homo sapiens	83-86
22800456-1	2012	OBJECTIVE: To analyze the variation of expression of proline-rich tyrosine kinase 2 (Pyk2) in the oxygen-induced retinal neovascularization mice model.	Oxygen	98-104	PTK2 protein tyrosine kinase 2 beta	Mus musculus	53-83
22800456-1	2012	OBJECTIVE: To analyze the variation of expression of proline-rich tyrosine kinase 2 (Pyk2) in the oxygen-induced retinal neovascularization mice model.	Oxygen	98-104	PTK2 protein tyrosine kinase 2 beta	Mus musculus	85-89
22800457-1	2012	OBJECTIVE: To observe the inhibition of neovascularisation in the oxygen-induced retinopathy (OIR) mice by a stromal cell-derived factor 1 (SDF-1) antagonist.	Oxygen	66-72	chemokine (C-X-C motif) ligand 12	Mus musculus	109-138
16129327-3	2005	Nebulisation of short acting beta-2-agonists, which usually requires oxygen administration, is still the first line treatment of a severe acute asthma attack.	Oxygen	69-75	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	29-35
22800457-1	2012	OBJECTIVE: To observe the inhibition of neovascularisation in the oxygen-induced retinopathy (OIR) mice by a stromal cell-derived factor 1 (SDF-1) antagonist.	Oxygen	66-72	chemokine (C-X-C motif) ligand 12	Mus musculus	140-145
22425808-6	2012	The inverse correlations between pre-exercise concentrations of visfatin and peak oxygen uptake (p&lt;0.05) in the transitory phase and between post- and pre-exercise differences (Delta) of visfatin and lactate concentrations (p&lt;0.05) in the preparatory phase were noted.	Oxygen	82-88	nicotinamide phosphoribosyltransferase	Homo sapiens	64-72
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	carbonic anhydrase 9	Homo sapiens	132-153
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	carbonic anhydrase 9	Homo sapiens	175-178
16098620-9	2005	Gassing cells with differing oxygen concentrations for 24h resulted in a maximum level of expression for CA9 at 1% oxygen, whereas with GLUT1 and LDHA maximal expression occurred at 0.01% oxygen, but at 0% oxygen with OPN.	Oxygen	29-35	carbonic anhydrase 9	Homo sapiens	105-108
16098620-9	2005	Gassing cells with differing oxygen concentrations for 24h resulted in a maximum level of expression for CA9 at 1% oxygen, whereas with GLUT1 and LDHA maximal expression occurred at 0.01% oxygen, but at 0% oxygen with OPN.	Oxygen	115-121	carbonic anhydrase 9	Homo sapiens	105-108
22207131-7	2012	Under the condition of 5% O(2), mammalian target of rapamycin complex 1 (mTORC1) was activated and led to the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) in T(h)17 cells.	Oxygen	26-30	CREB regulated transcription coactivator 1	Mus musculus	73-79
16098620-9	2005	Gassing cells with differing oxygen concentrations for 24h resulted in a maximum level of expression for CA9 at 1% oxygen, whereas with GLUT1 and LDHA maximal expression occurred at 0.01% oxygen, but at 0% oxygen with OPN.	Oxygen	115-121	carbonic anhydrase 9	Homo sapiens	105-108
16098620-9	2005	Gassing cells with differing oxygen concentrations for 24h resulted in a maximum level of expression for CA9 at 1% oxygen, whereas with GLUT1 and LDHA maximal expression occurred at 0.01% oxygen, but at 0% oxygen with OPN.	Oxygen	115-121	carbonic anhydrase 9	Homo sapiens	105-108
22259067-7	2012	TRH significantly enhanced mitochondrial complex I and IV enzyme activity and enhanced the oxygen consumption of human skin samples, which shows that the stimulated mitochondria are fully vital because the main source for cellular oxygen consumption is mitochondrial endoxidation.	Oxygen	91-97	thyrotropin releasing hormone	Homo sapiens	0-3
16028941-4	2005	In the case of chelating diethers, measurement of the corresponding equilibrium constants establish more stable eta(6),eta(5) adducts with five- over four-membered chelates and with smaller oxygen and carbon backbone substituents.	Oxygen	190-196	endothelin receptor type A	Homo sapiens	112-115
16028941-4	2005	In the case of chelating diethers, measurement of the corresponding equilibrium constants establish more stable eta(6),eta(5) adducts with five- over four-membered chelates and with smaller oxygen and carbon backbone substituents.	Oxygen	190-196	endothelin receptor type A	Homo sapiens	119-122
22259067-7	2012	TRH significantly enhanced mitochondrial complex I and IV enzyme activity and enhanced the oxygen consumption of human skin samples, which shows that the stimulated mitochondria are fully vital because the main source for cellular oxygen consumption is mitochondrial endoxidation.	Oxygen	231-237	thyrotropin releasing hormone	Homo sapiens	0-3
22354010-3	2012	Recently we have shown that inhibition of the oxygen sensor PHD2 in tumor cells blocks tumor growth due to the anti-proliferative activity of TGFbeta.	Oxygen	46-52	transforming growth factor, beta 1	Mus musculus	142-149
15883163-8	2005	By spectral analysis, flow cytometry, reverse transcriptase-PCR, immunocytochemistry, and immunoprecipitation it was shown that the extra-mitochondrial oxygen consumption was contributed by the NOX2 and NOX4 isoforms of the O2-*.	Oxygen	152-158	NADPH oxidase 4	Homo sapiens	203-207
15933265-2	2005	Human umbilical vein endothelium (HUVEC) function in an environment with 3% to 5% O2 and exhibit efficient adenosine membrane transport via human equilibrative nucleoside transporters 1 (hENT1).	Oxygen	82-84	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	187-192
15933265-4	2005	Hypoxia (0 to 24 hours, 2% and 1% O2) reduced maximal hENT1-adenosine transport velocity (V(max)) and maximal nitrobenzylthionosine (NBMPR, a high-affinity hENT1 protein ligand) binding, but increased extracellular adenosine concentration.	Oxygen	34-36	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	54-59
15933265-4	2005	Hypoxia (0 to 24 hours, 2% and 1% O2) reduced maximal hENT1-adenosine transport velocity (V(max)) and maximal nitrobenzylthionosine (NBMPR, a high-affinity hENT1 protein ligand) binding, but increased extracellular adenosine concentration.	Oxygen	34-36	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	156-161
12030801-6	2002	This result is attributable to the increase in UROD activity caused by the vitamin, which is a known scavenger of the oxygen reactive species that interfere with the activity of the enzyme.	Oxygen	118-124	uroporphyrinogen decarboxylase	Homo sapiens	47-51
11921096-11	2002	The addition of glucose can also increase the sulphite formation in strains overexpressing MET14 and/or SSU1 under oxygen-limiting conditions, while the addition of glucose has no significant effect under aerobic conditions.	Oxygen	115-121	Ssu1p	Saccharomyces cerevisiae S288C	104-108
21899873-2	2012	The crystal structure of OAM reveals that His225 is within hydrogen bond distance to the PLP phenolic oxygen, and may influence the pK(a) of the Schiff base during radical rearrangement.	Oxygen	102-108	pyridoxal phosphatase	Homo sapiens	89-92
11744691-10	2002	Lipoamide dehydrogenase also catalyzes NADH oxidation by oxygen, yielding hydrogen peroxide as the major product and superoxide radical as a minor product.	Oxygen	57-63	dihydrolipoamide dehydrogenase	Sus scrofa	0-23
15895398-7	2005	Thus, it appears that high oxygen in arterial blood is required for arterial expression of Dll4 and EphrinB2, which could be involved in cell-cell repulsion pathways that dictate the normal segregation of arteries and veins.	Oxygen	27-33	delta like canonical Notch ligand 4	Mus musculus	91-95
15985531-0	2005	Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.	Oxygen	9-15	adrenergic receptor, alpha 1d	Mus musculus	107-114
21899873-9	2012	From these data, we propose that His225 enhances radical stability by acting as a hydrogen bond acceptor to the phenolic oxygen, which favors the deprotonated state of the imino nitrogen and leads to greater resonance stabilization of the 2,4-diaminobutyryl-PLP radical intermediate.	Oxygen	121-127	pyridoxal phosphatase	Homo sapiens	258-261
11891810-0	2002	New alpha 2 globin chain variant with low oxygen affinity affecting the N-terminal residue and leading to N-acetylation [Hb Lyon-Bron alpha 1(NA1)Val --> Ac-Ala].	Oxygen	42-48	hemoglobin subunit alpha 2	Homo sapiens	4-18
22286561-4	2012	These studies indicate the increase of P-O-B bonds (up to Y=[B(2)O(3)]/([B(2)O(3)]+[P(2)O(5)]) 0.5 and B-O-B bonds, as well as the decrease of P-O-P bonds and non-bridging oxygens (NBOs) with rising B(2)O(3) content.	Oxygen	172-179	G protein-coupled receptor 15	Homo sapiens	103-108
16113801-9	2005	Exposure of neonatal mice to chronic hypoxia (10% O2), a stimulus that leads to an arrest of lung development, resulted in upregulation of MMP-2 with a concomitant downregulation of TIMP-2.	Oxygen	50-52	tissue inhibitor of metalloproteinase 2	Mus musculus	182-188
22573452-0	2012	Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes p450.	Oxygen	56-62	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-96
16833884-0	2005	Vibrational relaxation of molecular ions at low temperatures: O2(-) (v=1) + Ar.	Oxygen	62-64	arginine vasopressin receptor 1A	Homo sapiens	69-78
11914039-2	2002	We hypothesize that O2-induced changes in the neonatal lung are mediated by Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R).	Oxygen	20-22	insulin-like growth factor 1 receptor	Rattus norvegicus	117-131
11914039-2	2002	We hypothesize that O2-induced changes in the neonatal lung are mediated by Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R).	Oxygen	20-22	insulin-like growth factor 1 receptor	Rattus norvegicus	133-139
22573452-4	2012	Application of this method allowed for characterizing of peroxo-ferric and hydroperoxo-ferric intermediates, which are common for the oxygen activation mechanism in cytochromes P450, heme oxygenases, and nitric oxide synthases, as well as for the peroxide metabolism by peroxidases and catalases.	Oxygen	134-140	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	177-181
22122983-1	2012	OBJECTIVES: The function of netrin-1 in pathological angiogenesis and its role in retinal neovascularization were investigated in the retinas of oxygen-induced retinopathy (OIR) mice by inhibition of netrin-1.	Oxygen	145-151	netrin 1	Mus musculus	28-36
11787018-0	2002	Overexpression of alcohol dehydrogenase or pyruvate decarboxylase improves growth of hairy roots at reduced oxygen concentrations.	Oxygen	108-114	alcohol dehydrogenase 1	Arabidopsis thaliana	18-39
11787018-1	2002	Overexpression of Arabidopsis thaliana genes for the fermentation enzymes, alcohol dehydrogenase and pyruvate decarboxylase, improved the tolerance of A. thaliana hairy roots to low oxygen conditions.	Oxygen	182-188	alcohol dehydrogenase 1	Arabidopsis thaliana	75-96
15978510-5	2005	At 4500 m, the P300 latency returned to the baseline value after oxygen was inhaled.	Oxygen	65-71	E1A binding protein p300	Homo sapiens	15-19
15914639-15	2005	CONCLUSIONS: These results support the hypothesis that endogenous EphrinB2 and EphB4 are regulators of retinal NV during oxygen-induced retinopathy and may be useful targets for therapeutic intervention.	Oxygen	121-127	Eph receptor B4	Mus musculus	79-84
22815878-5	2012	Furthermore, cytotrophoblasts cultured under hypoxia (2% oxygen) in the presence or absence of nutlin-3 (a p53 activity stimulator) had higher levels of LC3B-II, DRAM, and M30 proteins and increased Bax mRNA expression compared with controls cultured under standard conditions.	Oxygen	57-63	microtubule associated protein 1 light chain 3 beta	Homo sapiens	153-157
15845361-4	2005	Using microarray assays, we discovered that SSAT was enhanced under both oxygen- and iron-deficient conditions.	Oxygen	73-79	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	44-48
11814419-0	2002	Down regulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model.	Oxygen	51-57	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	19-24
11814419-1	2002	The effect of hyperbaric oxygen (HBO) on cyclooxygenase-2 (COX-2) expression after transient focal ischemia was evaluated.	Oxygen	25-31	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	41-57
11814419-1	2002	The effect of hyperbaric oxygen (HBO) on cyclooxygenase-2 (COX-2) expression after transient focal ischemia was evaluated.	Oxygen	25-31	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	59-64
22496809-1	2012	Neuroglobin (Ngb), a neuron-specific oxygen-binding globin with an unknown function, has been proposed to play a key role in neuronal survival.	Oxygen	37-43	neuroglobin	Mus musculus	0-11
11929514-5	2002	Rox3 also caused a repressor effect (oxygen-independent) on a subset of genes related to subtelomeric proteins.	Oxygen	37-43	Rox3p	Saccharomyces cerevisiae S288C	0-4
12234095-1	2002	The mammalian EGLN family contains three paralagous genes (EGLN1, EGLN2, and EGLN3) encoding prolyl hydroxylase isoforms that mediate the oxygen-dependent targeting of the transcription factor hypoxia inducible factor alpha to the proteosome.	Oxygen	138-144	egl-9 family hypoxia inducible factor 2	Homo sapiens	66-71
12793920-13	2002	The a/APO(2) appeared to perform better than other indexes in this study, with a lower variability and a lower oxygen dependency.	Oxygen	111-117	TNF receptor superfamily member 10a	Homo sapiens	6-11
15618453-0	2005	Oxygen-dependent PAF receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle.	Oxygen	0-6	platelet activating factor receptor	Homo sapiens	17-29
15618453-3	2005	We studied the effect of oxygen tension on PAF-r binding and signaling in fetal PVSMC.	Oxygen	25-31	platelet activating factor receptor	Homo sapiens	43-48
15563275-2	2005	Three human PHDs (prolyl hydroxylase domain proteins, PHD1-PHD3) initiate oxygen-dependent degradation of HIF-alpha-subunits in normoxia.	Oxygen	74-80	egl-9 family hypoxia inducible factor 2	Homo sapiens	54-58
16013451-3	2005	Regular oscillatory patterns of oxygen consumption with period lengths characteristic of those observed for rates of NADH oxidation by ECTO-NOX proteins were observed to provide evidence for transfer of protons and electrons to reduce oxygen to water.	Oxygen	32-38	tripartite motif containing 33	Homo sapiens	135-139
22496809-1	2012	Neuroglobin (Ngb), a neuron-specific oxygen-binding globin with an unknown function, has been proposed to play a key role in neuronal survival.	Oxygen	37-43	neuroglobin	Mus musculus	13-16
16013451-3	2005	Regular oscillatory patterns of oxygen consumption with period lengths characteristic of those observed for rates of NADH oxidation by ECTO-NOX proteins were observed to provide evidence for transfer of protons and electrons to reduce oxygen to water.	Oxygen	235-241	tripartite motif containing 33	Homo sapiens	135-139
16013451-4	2005	The oscillations plus the resistance to inhibition by cyanide identify the bulk of the oxygen consumption as due to ECTO-NOX proteins.	Oxygen	87-93	tripartite motif containing 33	Homo sapiens	116-120
22427795-3	2012	Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p&lt;0.01), with 20% greater proton leak than vector controls (p&lt;0.01).	Oxygen	50-56	solute carrier family 25 member 27	Homo sapiens	28-32
16013451-7	2005	The results suggest that plasma membrane electron transport from internal donors to oxygen as an external acceptor is mediated through ECTO-NOX proteins and that electron transport to molecular oxygen may be differentially affected by external pyridine nucleotides depending on cell type.	Oxygen	84-90	tripartite motif containing 33	Homo sapiens	135-139
16013451-7	2005	The results suggest that plasma membrane electron transport from internal donors to oxygen as an external acceptor is mediated through ECTO-NOX proteins and that electron transport to molecular oxygen may be differentially affected by external pyridine nucleotides depending on cell type.	Oxygen	194-200	tripartite motif containing 33	Homo sapiens	135-139
11726405-5	2001	With 5% oxygen, mRNA for ICAM-1 and VCAM-1 rose by 100%, peaking between 0.5 and 1 h. ICAM-1 and VCAM-1 protein showed an increase between 2 and 4 h. Neutrophil adherence to hypoxia-exposed AEC was enhanced by 115%.	Oxygen	8-14	vascular cell adhesion molecule 1	Rattus norvegicus	36-42
11726405-5	2001	With 5% oxygen, mRNA for ICAM-1 and VCAM-1 rose by 100%, peaking between 0.5 and 1 h. ICAM-1 and VCAM-1 protein showed an increase between 2 and 4 h. Neutrophil adherence to hypoxia-exposed AEC was enhanced by 115%.	Oxygen	8-14	vascular cell adhesion molecule 1	Rattus norvegicus	97-103
15945660-0	2005	The structural and electronic properties of nanostructured Ce1-x-yZrxTbyO2 ternary oxides: unusual concentration of Tb3+ and metal&lt;--&gt;oxygen&lt;--&gt;metal interactions.	Oxygen	140-146	carboxylesterase 1	Homo sapiens	59-62
22167800-4	2011	The octahedral metal complex of RtcA ATP Mn(2+) includes nonbridging oxygens from each of the ATP phosphates, two waters, and Glu14 as the sole RtcA component.	Oxygen	69-76	RNA 3'-terminal phosphate cyclase	Homo sapiens	32-36
15945660-10	2005	The behavior of Ce1-x-yZrxTbyO2 illustrates how important can be metal&lt;--&gt;oxygen&lt;--&gt;metal interactions for determining the structural, electronic, and chemical properties of a ternary oxide.	Oxygen	80-86	carboxylesterase 1	Homo sapiens	16-19
15819984-6	2005	RESULTS: Strikingly, after 72 h of exposure to 90% O2, IGF-1Rneo/- mice had a significantly better survival rate during recovery than IGF-1R+/+ mice (77% versus 53%, P &lt; 0.05).	Oxygen	51-53	insulin-like growth factor 1	Mus musculus	55-60
11640911-1	2001	Central nervous system oxygen toxicity (CNS O2 toxicity) is preceded by release of hyperoxic vasoconstriction, which increases regional cerebral blood flow (rCBF).	Oxygen	23-29	CCAAT/enhancer binding protein zeta	Rattus norvegicus	157-161
11640911-1	2001	Central nervous system oxygen toxicity (CNS O2 toxicity) is preceded by release of hyperoxic vasoconstriction, which increases regional cerebral blood flow (rCBF).	Oxygen	44-46	CCAAT/enhancer binding protein zeta	Rattus norvegicus	157-161
11640911-2	2001	These increases in rCBF precede the onset of O2-induced convulsions.	Oxygen	45-47	CCAAT/enhancer binding protein zeta	Rattus norvegicus	19-23
11640911-5	2001	During exposures to hyperbaric oxygen rCBF decreased at 4 ATA, decreased for the initial 30 min at 5 ATA then gradually increased, and increased within 30 min at 6 ATA.	Oxygen	31-37	CCAAT/enhancer binding protein zeta	Rattus norvegicus	38-42
11640911-9	2001	The finding suggests that NO* overproduction initiates CNS O2 toxicity by increasing rCBF, which allows excessive O2 to be delivered to the brain.	Oxygen	59-61	CCAAT/enhancer binding protein zeta	Rattus norvegicus	85-89
11640911-9	2001	The finding suggests that NO* overproduction initiates CNS O2 toxicity by increasing rCBF, which allows excessive O2 to be delivered to the brain.	Oxygen	114-116	CCAAT/enhancer binding protein zeta	Rattus norvegicus	85-89
21930697-2	2011	The positive correlation with hypoxia-inducible factor 2alpha (HIF-2alpha) and carbonic anhydrase IX suggested that oxygen regulates myoglobin expression in breast carcinomas.	Oxygen	116-122	carbonic anhydrase 9	Homo sapiens	79-100
11709184-3	2001	We have identified a mutation in the Caenorhabditis elegans iron sulfur protein (isp-1) of mitochondrial complex III, which results in low oxygen consumption, decreased sensitivity to ROS, and increased life span.	Oxygen	139-145	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Caenorhabditis elegans	81-86
11641274-6	2001	Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration.	Oxygen	196-200	von Hippel-Lindau tumor suppressor	Homo sapiens	15-18
15542544-3	2005	In this report, exposure of human lung fibroblasts to 95% O2 decreased the incorporation of thymidine into DNA at 6 h and the incorporation of leucine into protein beginning at 12 h. The reductions in DNA and protein synthesis were accompanied by increased phosphorylation of eIF4E protein and reduced phosphorylation of 4E-BP1.	Oxygen	58-60	eukaryotic translation initiation factor 4E	Homo sapiens	276-281
15498965-7	2005	This study suggests that, in fruit fly embryos, 1) there is a dose-dependent relationship between cell cycle length and O2 levels in fruit fly embryos, and 2) stabilized cyclin A and E2F1 are likely to be the mediators of hypoxia-induced arrest at metaphase and pre-S phase.	Oxygen	120-122	Cyclin A	Drosophila melanogaster	170-178
21996590-4	2011	The experimental and calculated data verified high spin Ni(II), Co(II) and Mn(II) complexes and a bidentate binding through the carboxylic oxygen atoms (CCA2).	Oxygen	139-145	crystallin beta B2	Homo sapiens	153-157
15770070-1	2005	Cytochrome P450 (P450) constitutes a superfamily of enzymes which activate dioxygen and carry out monooxygenation reactions of large numbers of endogenous and xenobiotic compounds.	Oxygen	75-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-22
15678124-3	2005	We show that incubation of cortical neuron cultures with OPN protects against cell death from oxygen and glucose deprivation.	Oxygen	94-100	secreted phosphoprotein 1	Mus musculus	57-60
15833168-6	2005	Oxygen concentrations were tested in CYS-1 digital oxygen monitor after 24 hours of exposure.	Oxygen	0-6	cystin 1	Rattus norvegicus	37-42
11557353-7	2001	In addition, we were able to derive a pharmacophore model that relates the local average ESP and its distance to the 3beta-OH oxygen atom to the activity of the molecules.	Oxygen	126-132	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	89-92
11584268-4	2001	Purified recombinant Erv2p is a flavoenzyme that can catalyse O2-dependent formation of disulphide bonds.	Oxygen	62-64	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	21-26
11739897-1	2001	The residue Asp87, which is in the calcium-binding loop of bovine alpha-lactalbumin (alpha-LA) and provides a side-chain carboxylate oxygen for ligand Ca(II) co-ordination, was substituted by either alanine or asparagine.	Oxygen	133-139	carbonic anhydrase 2	Bos taurus	151-157
21951999-3	2011	The alpha-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent manner.	Oxygen	132-138	egl-9 family hypoxia inducible factor 2	Homo sapiens	104-108
11729666-6	2001	mPAP and TPR showed improvement on treatment with oxygen supplementation therapy and Isosorbide administration.	Oxygen	50-56	phospholipid phosphatase 1	Mus musculus	0-4
15622543-7	2005	Mice deficient in IL-1 receptor-associated kinase 4 (IRAK-4), which is pivotal for both IL-1beta and IL-18 signal transduction, were protected against oxygen-mediated neurotoxicity.	Oxygen	151-157	interleukin 18	Mus musculus	101-106
15745143-12	2005	The inverse relationship of both cerebral and renal markers with DO2 and VO2 suggests that increased levels of S100beta and NAG during CPB may primarily be caused by an oxygen deficit and secondary to the inflammatory response.	Oxygen	169-175	O-GlcNAcase	Homo sapiens	124-127
11819847-8	2001	CONCLUSION: HSC is sensitive to the oxygen, hypoxia enhances the expression of MMP-2 and the effect is more marked at the early stage; hyperoxia mainly raises the activity of MMP-2.	Oxygen	36-42	matrix metallopeptidase 2	Rattus norvegicus	79-84
22243227-3	2011	In the present study we investigated, in a mouse mesenchymal C3H10T1/2 stem cell model, the hypothesis that oxygen stress modulates tuftelin 1 expression in relation to HIF-1-alpha (Hif1a), in a mouse mesenchymal C3H10T1/2 stem cell model.	Oxygen	108-114	tuftelin 1	Mus musculus	132-142
11819847-8	2001	CONCLUSION: HSC is sensitive to the oxygen, hypoxia enhances the expression of MMP-2 and the effect is more marked at the early stage; hyperoxia mainly raises the activity of MMP-2.	Oxygen	36-42	matrix metallopeptidase 2	Rattus norvegicus	175-180
15634998-6	2005	Culture at 35 degrees C in 6% O(2)-10% CO(2) significantly enhanced the recovery of Aspergillus spp.	Oxygen	30-34	histocompatibility minor 13	Homo sapiens	96-99
22243227-4	2011	The results of the present study showed a biphasic induction of tuftelin, similar to the pattern of HIF-1-alpha expression, in MSCs subjected to a hypoxic insult of 1% O(2) through a period of 2-24 h. Immunocytochemistry analysis of the cells exposed to hypoxic insult for 2-24 h revealed the same biphasic pattern of tuftelin protein expression.	Oxygen	168-172	tuftelin 1	Mus musculus	64-72
15639640-1	2005	OBJECTIVES: To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes.	Oxygen	49-55	interleukin 1 beta	Bos taurus	67-89
11473111-8	2001	These structural properties of the heme pocket of Ngb are discussed with respect to its proposed in vivo oxygen delivery function.	Oxygen	105-111	neuroglobin	Mus musculus	50-53
15639640-7	2005	IL-1beta dose-dependently increased *NO production in both atmospheric and low oxygen conditions but the effect was more pronounced in low (1 and 5%) than in atmospheric (21%) oxygen tension (P&lt;0.001).	Oxygen	79-85	interleukin 1 beta	Bos taurus	0-8
22243227-6	2011	Based on our previous studies using the neuronal PC12 cell model, in which tuftelin induction was mediated by Hif1a, we propose that tuftelin is a member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating MSC function.	Oxygen	157-163	tuftelin 1	Rattus norvegicus	75-83
15639640-7	2005	IL-1beta dose-dependently increased *NO production in both atmospheric and low oxygen conditions but the effect was more pronounced in low (1 and 5%) than in atmospheric (21%) oxygen tension (P&lt;0.001).	Oxygen	176-182	interleukin 1 beta	Bos taurus	0-8
15639640-8	2005	Under low and atmospheric oxygen tension, iNOS gene expression was increased by IL-1beta, but to a lesser extent in 21% than in 1 or 5% oxygen (P&lt;0.01).	Oxygen	26-32	interleukin 1 beta	Bos taurus	80-88
22243227-6	2011	Based on our previous studies using the neuronal PC12 cell model, in which tuftelin induction was mediated by Hif1a, we propose that tuftelin is a member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating MSC function.	Oxygen	157-163	tuftelin 1	Rattus norvegicus	133-141
15639640-10	2005	At 21% oxygen, IL-1beta dose-dependently increased PGE(2) production while no significant effect was observed at 1 or 5% oxygen.	Oxygen	7-13	interleukin 1 beta	Bos taurus	15-23
21868707-1	2011	OBJECTIVE: Pericytes/pericyte precursors produce milk fat globule-associated protein with epidermal growth factor and factor VIII-like domains (MFG-E8) in vivo, and this alpha(v) integrin ligand enhances angiogenesis in tumors and in oxygen-induced retinopathy in mice.	Oxygen	234-240	integrin alpha V	Mus musculus	170-187
15639640-11	2005	COX-2 gene expression was significantly upregulated by IL-1beta in both low and atmospheric oxygen tension.	Oxygen	92-98	interleukin 1 beta	Bos taurus	55-63
15589726-2	2005	Oxygen-17 3QMAS spectra reveal changes in connectivities between AlO4 ([4]Al), AlO5 and AlO6 ([5,6]Al), BO3 ([3]B) and BO4 ([4]B) units, by quantifying populations of bridging oxygens such as Al-O-Al, Al-O-B and B-O-B and of non-bridging oxygens.	Oxygen	0-6	G protein-coupled receptor 15	Homo sapiens	201-217
11461922-7	2001	S-Nitrosoglutathione inhibits ornithine decarboxylase by an oxygen-independent mechanism likely by S-transnitrosation.	Oxygen	60-66	ornithine decarboxylase 1	Homo sapiens	30-53
11522632-0	2001	Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.	Oxygen	108-114	carbonic anhydrase 9	Homo sapiens	20-25
22616346-3	2011	Here we present a case of PCD with recurrent respiratory tract infections, bronchiectasis and severe PAH, who responded to treatment with Oxygen, IV broad spectrum antibiotics and oral sildenafil.	Oxygen	138-144	phenylalanine hydroxylase	Homo sapiens	101-104
11560893-8	2001	As oxygen consumption and ATP concentration have been reported to be unaffected in gro-1 mutants, our observations suggest that GRO-1 acts in mitochondria and regulates global physiology by unknown mechanisms.	Oxygen	3-9	Uncharacterized protein	Caenorhabditis elegans	128-133
15844597-4	2005	Dioxygen-labeled anti-sense and sense probes were synthesized by using a Sp6/T7 RNA synthesis kit in the present of Dig-UTP in vitro.	Oxygen	0-8	Sp6 transcription factor	Homo sapiens	73-76
15551405-2	2004	This variant hemoglobin caused by an alpha-globin gene mutation has decreased oxygen affinity.	Oxygen	78-84	hemoglobin subunit alpha 2	Homo sapiens	37-49
20368827-8	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Oxygen	183-189	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
11509659-0	2001	MGA2 is involved in the low-oxygen response element-dependent hypoxic induction of genes in Saccharomyces cerevisiae.	Oxygen	28-34	Mga2p	Saccharomyces cerevisiae S288C	0-4
11509659-6	2001	Further analyses using low-oxygen response element (LORE)-CYC1-lacZ fusion reporter assays and electrophoretic mobility shift assays (EMSAs) demonstrated that MGA2 significantly affects the LORE-dependent hypoxic induction pathway of gene expression.	Oxygen	27-33	Mga2p	Saccharomyces cerevisiae S288C	159-163
15726834-0	2004	Arteriolar responses to vasodilator stimuli and elevated P(O2) in renin congenic and Dahl salt-sensitive rats.	Oxygen	59-61	renin	Rattus norvegicus	66-71
22321929-1	2011	OBJECTIVE: To evaluate the preoperative effects of acute hypervolemic hemodilution (AHH) on intracranial pressure, cerebral oxygen supply-demand balance and cardiovascular functions of neurosurgical patients.	Oxygen	124-130	aryl hydrocarbon receptor repressor	Homo sapiens	84-87
11532904-3	2001	We have examined the mechanisms of interaction of O(2) with maxiK channels exploring the effect of hypoxia on maxiK currents recorded with the whole-cell and the inside-out configuration of the patch-clamp technique.	Oxygen	50-54	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	60-65
15488897-0	2004	The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase.	Oxygen	37-39	GTP cyclohydrolase 1	Homo sapiens	61-67
22321929-12	2011	CONCLUSION: Preoperative AHH in craniotomy will increase CI and maintain the balance of cerebral oxygen supply.	Oxygen	97-103	aryl hydrocarbon receptor repressor	Homo sapiens	25-28
15269007-0	2004	Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutations.	Oxygen	23-29	cytochrome c oxidase subunit 8A	Homo sapiens	33-53
11532904-11	2001	We conclude that O(2) interaction with maxiK channels does not require cytoplasmic mediators.	Oxygen	17-21	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	39-44
21814178-2	2011	As the Na/H exchanger-3 (NHE3) mediates the bulk of apical sodium transport and a significant fraction of oxygen consumption in the proximal tubule, we examined mechanisms by which ischemia-reperfusion affects the expression of NHE3.	Oxygen	106-112	solute carrier family 9 member A3	Rattus norvegicus	7-23
11506973-6	2001	Changes in tissue oxygen reflected the changes in rCBF; there was a decrease in both after sodium pentobarbitone, a decrease followed by a rebound after ketamine and a transient increase after chloral hydrate.	Oxygen	18-24	CCAAT/enhancer binding protein zeta	Rattus norvegicus	50-54
15500821-12	2004	The results of this study suggest the existence of a threshold in the rat model of OIR, such that a small change in blood oxygen profile triggers a disproportionate increase in subsequent neovascularization, which is accompanied by more dramatic changes of retinal VEGF level than VEGFR2 or PEDF level.	Oxygen	122-128	serpin family F member 1	Rattus norvegicus	291-295
21814178-2	2011	As the Na/H exchanger-3 (NHE3) mediates the bulk of apical sodium transport and a significant fraction of oxygen consumption in the proximal tubule, we examined mechanisms by which ischemia-reperfusion affects the expression of NHE3.	Oxygen	106-112	solute carrier family 9 member A3	Rattus norvegicus	25-29
15500331-10	2004	In 3, two phosphate oxygens of the cavity anion interact with the macrocycle, one of which participates in eta-2 H-bonding with ammonium groups.	Oxygen	20-27	DNA polymerase iota	Homo sapiens	107-112
21721952-5	2011	Exposure to 90% oxygen for 7 days after birth caused intensive CatK expression in the bronchial epithelium and alveolar macrophages of wild-type mice.	Oxygen	16-22	cathepsin K	Mus musculus	63-67
15511139-7	2004	The volume-based eta effect for ozone in the earlier study is not applicable to gas phase precursors of CAIs, due to the rarity of three-body recombination collisions at very low pressures and because of the high H(2) and H concentration in solar gas, which reduces gaseous O and gaseous dioxides and prevents the latter from acting as storage reservoirs for the two heavier oxygen isotopes.	Oxygen	375-381	endothelin receptor type A	Homo sapiens	17-20
15511139-8	2004	A surface eta effect yields XO*(2)(ads) that is mass-independently rich in (17)O and (18)O, and yields XO (ads)+O (ads) that is mass-independently poor in the two heavier oxygen isotopes.	Oxygen	171-177	endothelin receptor type A	Homo sapiens	10-13
11404258-2	2001	The current study tested the hypothesis that hypoxia-responsive growth factors, fibroblast growth factors (FGF-1 and FGF-2) and platelet-derived growth factor-BB (PDGF-BB), that activate tyrosine kinase receptors can reduce expression of NPR-C in PASMCs independent of environmental oxygen tension.	Oxygen	283-289	fibroblast growth factor 2	Rattus norvegicus	117-122
21721952-9	2011	These results suggest that CatK is involved in pulmonary development and it may be an important host-defence protease in the oxygen-stressed newborn lung.	Oxygen	125-131	cathepsin K	Mus musculus	27-31
11431362-2	2001	Oxygen-dependent degradation of HIF-1alpha, the regulatory subunit, requires binding to the von Hippel Lindau (VHL) protein.	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	92-109
11431362-2	2001	Oxygen-dependent degradation of HIF-1alpha, the regulatory subunit, requires binding to the von Hippel Lindau (VHL) protein.	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	111-114
21757507-0	2011	Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.	Oxygen	52-58	estrogen related receptor gamma	Homo sapiens	0-31
11472242-3	2001	TPH belongs to the family of the aromatic amino acid hydroxylases, including phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), which all have a strict requirement for dioxygen, non-heme iron (II) and tetrahydrobiopterin (BH4).	Oxygen	180-188	phenylalanine hydroxylase	Homo sapiens	77-102
11472242-3	2001	TPH belongs to the family of the aromatic amino acid hydroxylases, including phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), which all have a strict requirement for dioxygen, non-heme iron (II) and tetrahydrobiopterin (BH4).	Oxygen	180-188	phenylalanine hydroxylase	Homo sapiens	104-107
15496383-8	2004	Macrophage migration inhibition factor (MIF) and IL4 responses during anti-CD3 stimulation of immunized mice indicated that the role of anti-CD3 in generation of O2- is due to a synergistic effect by Th1 subsets of Th0 cells.	Oxygen	162-164	CD3 antigen, epsilon polypeptide	Mus musculus	75-78
15496383-8	2004	Macrophage migration inhibition factor (MIF) and IL4 responses during anti-CD3 stimulation of immunized mice indicated that the role of anti-CD3 in generation of O2- is due to a synergistic effect by Th1 subsets of Th0 cells.	Oxygen	162-164	CD3 antigen, epsilon polypeptide	Mus musculus	141-144
21757507-0	2011	Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.	Oxygen	52-58	estrogen related receptor gamma	Homo sapiens	33-41
21780841-2	2011	Thanks to its insensitivity to dioxygen and to its good catalytic reactivity, and in spite of its poor substrate selectivity, quinoprotein glucose dehydrogenase (PQQ-GDH) plays a prominent role among the redox enzymes that can be used for analytical purposes, such as glucose detection, enzyme-based bioaffinity assays, and the design of biofuel cells.	Oxygen	31-39	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	139-160
15474364-6	2004	The synRas-transgenic mice overexpressing constitutively activated Ras and phosphorylated kinases ERK1/2 in the brain were protected against oxygen neurotoxicity.	Oxygen	141-147	mitogen-activated protein kinase 3	Mus musculus	98-104
15347772-8	2004	Total MMP activity was doubled in resuscitated animals at endpoint compared with baseline (p=0.018), and the MMP-2 activity was significantly increased in piglets that were resuscitated with 21% O(2) (p=0.003) and 100% O2 (p=0.001) compared with baseline.	Oxygen	195-199	matrix metallopeptidase 2	Homo sapiens	109-114
15347772-9	2004	MMP-2 mRNA level was 100% increased in piglets that were resuscitated with 100% O2 as compared with 21% O2 (p &lt; 0.05).	Oxygen	80-82	matrix metallopeptidase 2	Homo sapiens	0-5
15347772-9	2004	MMP-2 mRNA level was 100% increased in piglets that were resuscitated with 100% O2 as compared with 21% O2 (p &lt; 0.05).	Oxygen	104-106	matrix metallopeptidase 2	Homo sapiens	0-5
15489001-2	2004	Myoglobin (Mb) is highly expressed in the heart, where it facilitates O2 diffusion, mitochondrial respiration, and scavenges reactive O2 species.	Oxygen	70-72	myoglobin	Rattus norvegicus	0-9
15489001-2	2004	Myoglobin (Mb) is highly expressed in the heart, where it facilitates O2 diffusion, mitochondrial respiration, and scavenges reactive O2 species.	Oxygen	70-72	myoglobin	Rattus norvegicus	11-13
15489001-2	2004	Myoglobin (Mb) is highly expressed in the heart, where it facilitates O2 diffusion, mitochondrial respiration, and scavenges reactive O2 species.	Oxygen	134-136	myoglobin	Rattus norvegicus	0-9
15489001-2	2004	Myoglobin (Mb) is highly expressed in the heart, where it facilitates O2 diffusion, mitochondrial respiration, and scavenges reactive O2 species.	Oxygen	134-136	myoglobin	Rattus norvegicus	11-13
15509746-3	2004	After 3-8 hr of oxygen and glucose deprivation (OGD), NKCC1-mediated 86Rb influx was significantly increased in astrocytes from NKCC1 wild-type (NKCC1+/+) and heterozygous mutant (NKCC1+/-) mice.	Oxygen	16-22	solute carrier family 12, member 2	Mus musculus	54-59
11412041-9	2001	These findings indicate that the increased cellular invasiveness observed under reduced oxygen conditions may be due in part to a shift in the balance between MMPs and their inhibitors favoring increased MMP activity.	Oxygen	88-94	matrix metallopeptidase 2	Homo sapiens	159-163
11795592-5	2001	Importantly, the classical features of regulation by iron and oxygen availability are reflected in regulation of the HIF-alpha/pVHL interaction.	Oxygen	62-68	von Hippel-Lindau tumor suppressor	Homo sapiens	127-131
11375751-4	2001	Oxygen radicals can be formed in dopaminergic neurons by redox cycling of MPP+, the active metabolite of MPTP.	Oxygen	0-6	M-phase phosphoprotein 6	Homo sapiens	74-77
11336512-1	2001	The von Hippel-Lindau tumor-suppressor protein (pVHL) regulates the stability of HIF1 alpha and HIF2 alpha and thus is pivotal in cellular responses to changes in oxygen tension.	Oxygen	163-169	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
11336512-5	2001	As cytotrophoblasts attached to and invaded the uterus, which results in their increased exposure to oxygen, pVHL staining was abruptly downregulated concordant with localization of HIF2 alpha to the nucleus.	Oxygen	101-107	von Hippel-Lindau tumor suppressor	Homo sapiens	109-113
15509746-3	2004	After 3-8 hr of oxygen and glucose deprivation (OGD), NKCC1-mediated 86Rb influx was significantly increased in astrocytes from NKCC1 wild-type (NKCC1+/+) and heterozygous mutant (NKCC1+/-) mice.	Oxygen	16-22	solute carrier family 12, member 2	Mus musculus	128-133
15509746-3	2004	After 3-8 hr of oxygen and glucose deprivation (OGD), NKCC1-mediated 86Rb influx was significantly increased in astrocytes from NKCC1 wild-type (NKCC1+/+) and heterozygous mutant (NKCC1+/-) mice.	Oxygen	16-22	solute carrier family 12, member 2	Mus musculus	128-133
15509746-3	2004	After 3-8 hr of oxygen and glucose deprivation (OGD), NKCC1-mediated 86Rb influx was significantly increased in astrocytes from NKCC1 wild-type (NKCC1+/+) and heterozygous mutant (NKCC1+/-) mice.	Oxygen	16-22	solute carrier family 12, member 2	Mus musculus	128-133
11336512-6	2001	In vitro, hypoxia (2% O(2)) upregulated cytotrophoblast pVHL expression together with HIF2 alpha, which localized to the cytoplasm; culture under well-oxygenated conditions greatly reduced levels of both molecules.	Oxygen	22-26	von Hippel-Lindau tumor suppressor	Homo sapiens	56-60
11336512-8	2001	Furthermore, these data provide the first example of oxygen-dependent changes in pVHL abundance.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	81-85
21319150-6	2011	RESULTS: LAMP3 was variably expressed in breast cancer cell lines and induced in an oxygen concentration-dependent manner.	Oxygen	84-90	lysosomal associated membrane protein 3	Homo sapiens	9-14
15569437-0	2004	[The inhibitory effects of angiostatin on retinal neovascularization induced by oxygen].	Oxygen	80-86	plasminogen	Mus musculus	27-38
21742773-4	2011	However, in the absence of p53, RelA was transported into the mitochondria and recruited to the mitochondrial genome where it repressed mitochondrial gene expression, oxygen consumption, and cellular ATP levels.	Oxygen	167-173	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-36
15163614-5	2004	GLUT1 expression was higher following 2% oxygen culture compared with 7% and 20% cultured blastocysts.	Oxygen	41-47	solute carrier family 2 member 1	Bos taurus	0-5
11331007-3	2001	Despite these structural similarities, the PI-PLC reaction is slowed 10(5)-fold upon substitution of one of the phosphate nonbridging oxygen atoms with sulfur, whereas a much smaller effect is observed in the analogous RNase A reaction.	Oxygen	134-140	phospholipase C beta 1	Homo sapiens	43-49
11396794-0	2001	Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by O2 availability in vitro and in vivo.	Oxygen	110-112	MX dynamin like GTPase 1	Homo sapiens	88-92
21678551-5	2011	These thin films are stable between pH 1 and 13 and have the lowest overpotential (eta) for the oxygen evolution reaction (OER) of any yet reported.	Oxygen	96-102	endothelin receptor type A	Homo sapiens	83-86
15192081-2	2004	RII beta(-/-) mice also have an increase in resting oxygen consumption along with a 4-fold increase in the brown adipose-specific mitochondrial uncoupling protein 1 (UCP1).	Oxygen	52-58	protein kinase, cAMP dependent regulatory, type II beta	Mus musculus	0-8
15192081-6	2004	We discovered that RII beta(-/-) mice exhibit nocturnal hyperactivity in addition to the increased oxygen consumption at rest.	Oxygen	99-105	protein kinase, cAMP dependent regulatory, type II beta	Mus musculus	19-27
15192081-7	2004	Disruption of UCP1 in RII beta(-/-) mice reduced basal oxygen consumption but did not prevent the nocturnal hyperactivity.	Oxygen	55-61	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	14-18
21666701-8	2011	RESULTS: Incubation of HCC cells under hypoxia (1% O2, 5% CO2, 94% N2) for 36 h significantly increased CA-IX expression level.	Oxygen	51-53	carbonic anhydrase 9	Homo sapiens	104-109
15265941-0	2004	Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients.	Oxygen	76-82	platelet factor 4	Homo sapiens	0-17
15265941-0	2004	Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients.	Oxygen	76-82	platelet factor 4	Homo sapiens	18-23
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Oxygen	47-53	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	199-203
21806264-2	2011	Accurately measuring the metabolic rate of oxygen (MRO(2)) can be helpful for fundamental pathophysiological studies, and even early diagnosis and treatment of disease.	Oxygen	43-49	maestro	Homo sapiens	51-54
15240140-1	2004	The von Hippel-Lindau (VHL) is a known tumor suppressor that binds to alpha-subunits of hypoxia-inducible factors and induces ubiquitin-mediated degradation of the protein in an oxygen-dependent manner.	Oxygen	178-184	von Hippel-Lindau tumor suppressor	Homo sapiens	4-21
15215895-0	2004	Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.	Oxygen	0-6	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	29-33
21681335-2	2011	Nitric oxide (NO) derived from the constitutive isoforms of eNOS and nNOS plays four kinds of inhibitory effects on the myocardium: reducing the contractile frequency of cardiomyocyte, slightly attenuating cardiac contractility, accelerating relaxation and increasing distensibility of cardiomyocyte, and slightly inhibiting mitochondrial respiration and improving the efficiency of myocardial oxygen consumption.	Oxygen	394-400	nitric oxide synthase 1	Homo sapiens	69-73
15215895-3	2004	Disulfide formation in SOD1 by O2 is slow but is greatly accelerated by the Cu-bound form of CCS (Cu-CCS) in vivo and in vitro even in the presence of excess reductants; once formed, this disulfide is kinetically stable.	Oxygen	31-33	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	23-27
21350118-4	2011	The CMAH enzyme catalyzes the generation of CMP-Neu5Gc by the transfer of a single oxygen atom to the acyl group of CMP-Neu5Ac.	Oxygen	83-89	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	4-8
15303088-4	2004	We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development.	Oxygen	88-94	serpin family F member 1	Homo sapiens	27-60
15303088-4	2004	We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development.	Oxygen	88-94	serpin family F member 1	Homo sapiens	62-66
15303088-14	2004	Retinal PEDF expression was elevated in pups in the 50/10 OIR model compared to control at P7, immediately after 50% oxygen.	Oxygen	117-123	serpin family F member 1	Homo sapiens	8-12
21389259-2	2011	Their regulation is principally by oxygen-dependent degradation, which is initiated by hydroxylation of specific proline residues followed by binding of von Hippel-Lindau (VHL) protein.	Oxygen	35-41	von Hippel-Lindau tumor suppressor	Homo sapiens	153-170
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Oxygen	192-198	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	153-157
15232683-7	2004	Notably, the renal medullary changes in oxygen tension, oxygen consumption, lactate : pyruvate ratio and pH were preventable by inhibition of aldose reductase.	Oxygen	40-46	aldo-keto reductase family 1 member B1	Rattus norvegicus	142-158
15232683-7	2004	Notably, the renal medullary changes in oxygen tension, oxygen consumption, lactate : pyruvate ratio and pH were preventable by inhibition of aldose reductase.	Oxygen	56-62	aldo-keto reductase family 1 member B1	Rattus norvegicus	142-158
21389259-2	2011	Their regulation is principally by oxygen-dependent degradation, which is initiated by hydroxylation of specific proline residues followed by binding of von Hippel-Lindau (VHL) protein.	Oxygen	35-41	von Hippel-Lindau tumor suppressor	Homo sapiens	172-175
21397007-1	2011	Yeast lacking copper-zinc superoxide dismutase (sod1 ) have a number of oxygen-dependent defects, including auxotrophies for lysine and methionine and sensitivity to oxygen.	Oxygen	72-78	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	48-52
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	glycoprotein A33 (transmembrane)	Mus musculus	134-145
15485083-1	2004	The aim of this study was to evaluate the prophylactic potential of hyperbaric oxygenation treatment and the timing of hyperbaric oxygen (HBO2) therapy for cyclophosphamide-(CYP) induced cystitis in rats.	Oxygen	79-85	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	174-177
21397007-1	2011	Yeast lacking copper-zinc superoxide dismutase (sod1 ) have a number of oxygen-dependent defects, including auxotrophies for lysine and methionine and sensitivity to oxygen.	Oxygen	166-172	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	48-52
15178343-1	2004	The recent identification of hypoxia-inducible-factor (HIF) prolyl hydroxylases (PHD1, 2, and 3), which modify HIF-1 alpha in an oxygen-dependent manner, provided an important link between oxygen availability and hypoxia-induced gene expression.	Oxygen	129-135	egl-9 family hypoxia inducible factor 2	Homo sapiens	81-95
21397007-8	2011	In early stages of culture, sod1  cells consume more oxygen and have more mitochondrial mass than wild-type cells, indicating that glucose repression is not fully activated.	Oxygen	53-59	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	28-32
21439370-11	2011	Together, these results indicate that ROS-induced separation of GDI from RhoA leads to RhoA activation with oxygen toxicity.	Oxygen	108-114	ras homolog family member A	Mus musculus	73-77
15167795-2	2004	PQQ-dependent GDH is of interest because of its high activity and independence of dissolved oxygen in catalyzing the transfer of electrons from glucose to an electron mediator.	Oxygen	92-98	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	14-17
15500003-4	2004	CA IX expression is upregulated by Hypoxia Inducible Factor-1 (HIF-1), which is negatively controlled by oxygen via wild type VHL protein and is also regulated by the cell redox state.	Oxygen	105-111	carbonic anhydrase 9	Homo sapiens	0-5
15500003-4	2004	CA IX expression is upregulated by Hypoxia Inducible Factor-1 (HIF-1), which is negatively controlled by oxygen via wild type VHL protein and is also regulated by the cell redox state.	Oxygen	105-111	von Hippel-Lindau tumor suppressor	Homo sapiens	126-129
15150283-4	2004	Consistent with a reduction in hCG, explants under 17% O(2) (with and without TNFalpha) showed a progressive degeneration of syncytiotrophoblast (ST) (days 0-2) followed by a restoration of hCG (days 4-8) localized to newly differentiated but not syncytialized CTs.	Oxygen	55-59	glycoprotein hormones, alpha polypeptide	Homo sapiens	31-34
15150283-4	2004	Consistent with a reduction in hCG, explants under 17% O(2) (with and without TNFalpha) showed a progressive degeneration of syncytiotrophoblast (ST) (days 0-2) followed by a restoration of hCG (days 4-8) localized to newly differentiated but not syncytialized CTs.	Oxygen	55-59	glycoprotein hormones, alpha polypeptide	Homo sapiens	190-193
15153505-9	2004	SP-A significantly decreased Mphi oxygen consumption in response to PMA and OpZy.	Oxygen	34-40	surfactant protein A1	Homo sapiens	0-4
15148401-3	2004	Here, we present the crystal structure of the key intermediate in the hydroxylation reaction of xanthine oxidoreductase with a slow substrate, in which the carbon-oxygen bond of the product is formed, yet the product remains complexed to the molybdenum.	Oxygen	163-169	xanthine dehydrogenase	Homo sapiens	96-119
15100044-1	2004	Reduced cytochrome c oxidase binds molecular oxygen, yielding an oxygenated intermediate first (Oxy) and then converts it to water via the reaction intermediates of P, F, and O in the order of appearance.	Oxygen	45-51	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	8-28
15053633-7	2004	+.O2-, would emerge as a KIE1/2 factor in the rates of the ensuing radical chain, the magnitude of the observed KIE must be associated with the hydride transfer reaction that yields a diamagnetic species: O3 + HO2- HO3- + O2.	Oxygen	2-4	heme oxygenase 2	Homo sapiens	210-213
14512376-5	2004	XOR was recovered from the MNP largely converted to its oxygen radical generating, reversible O-form, and alveolar MNP exhibited increased oxidative stress as evidenced by increased nitrotyrosine staining.	Oxygen	56-62	xanthine dehydrogenase	Rattus norvegicus	0-3
14762707-14	2004	On the other hand, the amino group in carbamoylphosphonic acid2 lowers the stability of the complexes with metals favoring oxygen ligands (Ca, Mg and Fe) and increases the selectivity towards Zn.	Oxygen	123-129	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	58-63
14691445-4	2004	When VHL regulation of both HIF-1alpha N- and C-terminal oxygen-dependent degradation domains (HIF-ODDD) was investigated, it was found that only ubiquitination of the C-terminal HIF-ODDD was affected by the deletion of the VHL C-terminus.	Oxygen	57-63	von Hippel-Lindau tumor suppressor	Homo sapiens	5-8
14691445-5	2004	When RCC4 cells expressing C-terminal truncations of VHL were exposed to graded hypoxia, differences in the induction of HIF-1alpha were observed in comparison with full-length VHL, with a shift in the maximal induction of HIF-1alpha to a higher oxygen tension.	Oxygen	246-252	von Hippel-Lindau tumor suppressor	Homo sapiens	53-56
15134337-2	2004	Until now, the O2-responsive elements in the liver-specific GK promoter are unknown, and therefore the aim of this study was to identify the O2-responsive element in this promoter.	Oxygen	15-17	glucokinase	Rattus norvegicus	60-62
15134337-2	2004	Until now, the O2-responsive elements in the liver-specific GK promoter are unknown, and therefore the aim of this study was to identify the O2-responsive element in this promoter.	Oxygen	141-143	glucokinase	Rattus norvegicus	60-62
15134337-9	2004	Thus, HIF-1 and USF may play differential roles in the modulation of GK expression in response to O2.	Oxygen	98-100	glucokinase	Rattus norvegicus	69-71
15050521-5	2004	Mackerel Mb had the highest P50 value at 25 degrees C (3.7 mmHg), corresponding to the lowest O2 affinity, followed by zebrafish (1.0 mmHg), yellowfin tuna (1.0 mmHg), and N. coriiceps (0.6 mmHg).	Oxygen	94-96	myoglobin	Danio rerio	9-11
14767570-3	2004	The product of the VHL gene, pVHL, is known to be a component of ubiquitin ligase which targets the transcription factor such as hypoxia-inducible factor (HIF) for degradation in the presence of oxygen.	Oxygen	195-201	von Hippel-Lindau tumor suppressor	Homo sapiens	29-33
14691204-2	2004	The ARNT protein also forms heterodimers with other proteins such as HIF-1alpha and HIF-2alpha to alter gene expression in response to low oxygen conditions.	Oxygen	139-145	aryl hydrocarbon receptor nuclear translocator	Danio rerio	4-8
14691204-2	2004	The ARNT protein also forms heterodimers with other proteins such as HIF-1alpha and HIF-2alpha to alter gene expression in response to low oxygen conditions.	Oxygen	139-145	hypoxia inducible factor 1 subunit alpha, like 2	Danio rerio	84-94
14615480-4	2004	Compared with wild-type (WT) mice, male and female C3(-/-) ASP-deficient mice had elevated oxygen consumption (VO2) in both the active (dark) and resting (light) phases of the diurnal cycle: +8.9% males (p &lt; 0.05) +9.4% females (p &lt; 0.05).	Oxygen	91-97	complement component 3	Mus musculus	59-62
14757749-2	2004	Rather than relying on small molecule oxidants like glutathione, it is now clear that disulfide formation is driven by a protein relay involving Ero1, a novel conserved FAD-dependent enzyme, and protein disulfide isomerase (PDI); Ero1 is oxidized by molecular oxygen and in turn acts as a specific oxidant of PDI, which then directly oxidizes disulfide bonds in folding proteins.	Oxygen	260-266	prolyl 4-hydroxylase subunit beta	Homo sapiens	195-222
14757749-2	2004	Rather than relying on small molecule oxidants like glutathione, it is now clear that disulfide formation is driven by a protein relay involving Ero1, a novel conserved FAD-dependent enzyme, and protein disulfide isomerase (PDI); Ero1 is oxidized by molecular oxygen and in turn acts as a specific oxidant of PDI, which then directly oxidizes disulfide bonds in folding proteins.	Oxygen	260-266	prolyl 4-hydroxylase subunit beta	Homo sapiens	224-227
15299286-1	2004	In the present report, we show that bovine articular chondrocytes cultured in low oxygen tension, i.e. in conditions mimicking their hypoxic in vivo environment, respond to IL-1beta (10 ng/ml) by an increased DNA binding activity of NF-kappaB and AP-1 transcription factors.	Oxygen	82-88	interleukin 1 beta	Bos taurus	173-181
15299286-5	2004	Rhein was capable of reducing the IL-1beta-stimulated ERK1/ERK2 pathway whatever the tension of oxygen present in the environment.	Oxygen	96-102	interleukin 1 beta	Bos taurus	34-42
15134488-7	2004	We focused on the amide function of these compounds because recent investigations revealed that both the amide hydrogen and carbonyl oxygen of indolactam-V (ILV) are involved in hydrogen bonding with the C1B domains of PKCdelta.	Oxygen	133-139	protein kinase C delta	Homo sapiens	219-227
14674304-9	2004	A common pathway (i.e. oxygen sensing) has been shown for VHL and SDHX.	Oxygen	23-29	von Hippel-Lindau tumor suppressor	Homo sapiens	58-61
14750006-1	2004	The aim of this study was to investigate the development of exercise-induced hypoxemia (EIH defined as an exercise decrease &gt; 4 % in oxygen arterial saturation, i. e. SaO (2) measured with a portable pulse oximeter) in twelve sportsmen and ten sportswomen (18.5 +/- 0.5 years) who were non-elite and not initially engaged in endurance sport or training.	Oxygen	136-142	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	170-173
14997018-0	2004	Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model.	Oxygen	44-50	mitogen activated protein kinase 14	Rattus norvegicus	142-150
14959816-4	2004	A working party of the Association of Palliative Medicine Science Committee set out to examine the evidence concerning the use of oxygen for the palliation of breathlessness in COPD, advanced cancer and chronic heart failure and to make recommendations for clinicians working in palliative care.	Oxygen	130-136	COPD	Homo sapiens	177-181
14959816-6	2004	There was no evidence available for heart failure, very little for advanced cancer and although there were a number of trials on the use of oxygen in COPD very few, until recently, used reduction of breathlessness as an outcome measure.	Oxygen	140-146	COPD	Homo sapiens	150-154
11378622-0	2001	Oxygen effects on glucose meter measurements with glucose dehydrogenase- and oxidase-based test strips for point-of-care testing.	Oxygen	0-6	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	50-71
11358515-11	2001	A possible relationship among the integrity of the PLP cleft, the productive binding of O2 and the transition to a closed conformational state of DDC is discussed.	Oxygen	88-90	pyridoxal phosphatase	Homo sapiens	51-54
11331612-3	2001	The VHL gene product, pVHL, is a component of a ubiquitin ligase which targets the transcription factor known as hypoxia-inducible factor (HIF) for degradation in the presence of oxygen.	Oxygen	179-185	von Hippel-Lindau tumor suppressor	Homo sapiens	22-26
11304794-6	2001	Therefore, the absence of essential SH groups in G6PD in (pre)neoplastic cells is held responsible for the oxygen insensitivity phenomenon.	Oxygen	107-113	glucose-6-phosphate dehydrogenase	Rattus norvegicus	49-53
11304794-7	2001	We conclude that oxygen insensitivity of the histochemical assay for G6PD activity is a fast, easy, and cheap tool to diagnose (pre)neoplasms in rat liver.	Oxygen	17-23	glucose-6-phosphate dehydrogenase	Rattus norvegicus	69-73
11306502-6	2001	We postulate that oxygen and cell "survival/growth factors" delivered via blood vessels protect retinoblastoma cells from apoptosis.	Oxygen	18-24	RB transcriptional corepressor 1	Homo sapiens	96-110
11359447-6	2001	A progressive and significant decrease in the two most important enzymes of this route, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, was detected as a function of age; in spite of this reduction, the NADPH produced by cells from old animals seems not limiting for the O2*(-) production.	Oxygen	295-297	glucose-6-phosphate dehydrogenase	Rattus norvegicus	88-121
11401064-3	2001	The results showed that VEGF mRNA abundance was increased three-fold and that of bFGF 1.5-fold when 12% O2+5% CO2 were breathed, but TGF-beta1 did not change.	Oxygen	104-106	fibroblast growth factor 2	Rattus norvegicus	81-85
11248020-1	2001	Phototropin, a major blue-light receptor for phototropism in seed plants, exhibits blue-light-dependent autophosphorylation and contains two light, oxygen, or voltage (LOV) domains and a serine/threonine kinase domain.	Oxygen	148-154	phototropin 1	Arabidopsis thaliana	0-11
11230353-8	2001	In contrast, intracerebroventricular leptin, at a dose that had no cardiovascular effects in ad lib control animals, completely prevented fasting-induced decreases in light-phase heart rate and oxygen consumption and blunted fasting-induced reductions in dark-phase heart rate and oxygen consumption.	Oxygen	194-200	leptin	Rattus norvegicus	37-43
11230353-8	2001	In contrast, intracerebroventricular leptin, at a dose that had no cardiovascular effects in ad lib control animals, completely prevented fasting-induced decreases in light-phase heart rate and oxygen consumption and blunted fasting-induced reductions in dark-phase heart rate and oxygen consumption.	Oxygen	281-287	leptin	Rattus norvegicus	37-43
11338533-4	2001	Increased levels of HbA1c and 2,3-DPG in the studied combination of diseases augmented disorders of O2 binding to hemoglobin, which led to hypoxia.	Oxygen	100-102	hemoglobin subunit alpha 2	Homo sapiens	20-31
11214321-7	2001	Thus, the oxygen-regulated cellular mechanism that couples the synthesis and export of haemoglobin-derived NO bioactivity operates, at least in part, through formation of AE1-SNO at the membrane-cytosol interface.	Oxygen	10-16	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	171-174
11144255-3	2001	EF5 and other 2-nitroimidazoles are used to detect hypoxia, because the rate of their bioreductive metabolism is inversely dependent on oxygen partial pressure.	Oxygen	136-142	angiogenin, ribonuclease A family, member 3	Mus musculus	0-3
11150917-1	2001	Nitric oxide synthase (NOS) catalyzes nitric oxide (NO) formation from L-arginine in the presence of molecular oxygen and NADPH.	Oxygen	111-117	nitric oxide synthase 1	Homo sapiens	0-21
11150917-5	2001	The apparent K(m) values for molecular oxygen were 21.6 +/- 1.5 and 9.4 +/- 1.3 micromol/l for nNOS and eNOS, respectively.	Oxygen	39-45	nitric oxide synthase 1	Homo sapiens	95-99
11121211-1	2001	Numerical simulations of oxygen diffusion from the capillaries in tumor tissue were used to predict the capillary oxygen supply within and near hypoxic regions of the RIF-1 tumor.	Oxygen	25-31	replication timing regulatory factor 1	Homo sapiens	167-172
11121211-1	2001	Numerical simulations of oxygen diffusion from the capillaries in tumor tissue were used to predict the capillary oxygen supply within and near hypoxic regions of the RIF-1 tumor.	Oxygen	114-120	replication timing regulatory factor 1	Homo sapiens	167-172
11175344-3	2000	Among a group of newly identified VHL target genes the majority but not all were regulated by oxygen, indicating that whilst dysregulation of the HIF system makes a dominant contribution to alterations in transcription, VHL has other influences on patterns of gene expression.	Oxygen	94-100	von Hippel-Lindau tumor suppressor	Homo sapiens	34-37
11106681-8	2000	The 4-HPR and safingol combination was cytotoxic in low-oxygen conditions and was minimally toxic to normal fibroblasts and bone marrow myeloid progenitor cells.	Oxygen	56-62	haptoglobin-related protein	Homo sapiens	6-9
11140697-4	2000	Adult mice exposed to greater than 95% oxygen concentrations for 48 to 88 hours had increased whole-lung mRNA levels of Bax and Bcl-X(L), no change in Bak, Bad, or Bcl-2, and decreased levels of Bcl-w and Bfl-1.	Oxygen	39-45	BCL2-like 1	Mus musculus	128-136
11078341-0	2000	Deletion of the endothelin-A-receptor suppresses oxygen-induced constriction but not postnatal closure of the ductus arteriosus.	Oxygen	49-55	endothelin receptor type A	Mus musculus	16-37
11132644-1	2000	Structures of reaction intermediates of bovine cytochrome c oxidase (CcO) in the reactions of its fully reduced form with O2 and fully oxidized form with H2O2 were investigated with time-resolved resonance Raman (RR) and infrared spectroscopy.	Oxygen	122-124	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	47-67
11132644-1	2000	Structures of reaction intermediates of bovine cytochrome c oxidase (CcO) in the reactions of its fully reduced form with O2 and fully oxidized form with H2O2 were investigated with time-resolved resonance Raman (RR) and infrared spectroscopy.	Oxygen	122-124	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	69-72
11132644-2	2000	Six oxygen-associated RR bands were observed for the reaction of CcO with O2.	Oxygen	4-10	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	65-68
11132644-2	2000	Six oxygen-associated RR bands were observed for the reaction of CcO with O2.	Oxygen	74-76	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	65-68
11132644-6	2000	The reaction of oxidized CcO with H2O2 yields the same oxygen isotope-sensitive bands as those of P and F, indicating the identity of intermediates.	Oxygen	55-61	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	25-28
11059537-9	2000	Although there were significant correlations between the factors, a multivariate Cox regression analysis identified the duration of oxygen therapy as a significant independent risk factor (HR = 1.006, P = 0.001).	Oxygen	132-138	cytochrome c oxidase subunit 8A	Homo sapiens	81-84
15686271-1	2004	To investigate whether Hyperbaric Oxygen Therapy (HBO2) could improve neurologic deficits and regional cerebral blood flow (rCBF) in chronic traumatic brain injuries (TBI), the authors employed a nonrandomized control pilot trial.	Oxygen	34-40	CCAAT/enhancer binding protein zeta	Rattus norvegicus	124-128
14653816-7	2003	The activities of the enzymes lysine 2-oxoglutate reductase and saccharopine dehydrogenase, both involved in lysine degradation in the maize endosperm were also determined and shown to be reduced several fold with the introduction of the o2, fl1 and fl2 mutations in the Oh43+ inbred line, whereas wild-type activity levels were verified in the Oh43o1 mutant.	Oxygen	238-240	Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410	Zea mays	64-90
14653816-7	2003	The activities of the enzymes lysine 2-oxoglutate reductase and saccharopine dehydrogenase, both involved in lysine degradation in the maize endosperm were also determined and shown to be reduced several fold with the introduction of the o2, fl1 and fl2 mutations in the Oh43+ inbred line, whereas wild-type activity levels were verified in the Oh43o1 mutant.	Oxygen	238-240	zea floricaula/leafy 1	Zea mays	242-245
14645679-9	2003	Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly or indirectly be involved in the regulation of AhR-dependent transcriptional activity by nickel and other hypoxia-mimicking agents.	Oxygen	53-59	aryl hydrocarbon receptor	Homo sapiens	137-140
14612244-1	2003	To study the role of the GTS1 gene in the energy metabolism oscillation in continuous cultures of yeast from the physical aspect, time-series data of dissolved oxygen oscillations were analyzed by transforming them into power spectra and by creating two-dimensional trajectories using time delay embedding technique.	Oxygen	160-166	Gts1p	Saccharomyces cerevisiae S288C	25-29
14530297-6	2003	In vitro, CCR1 protein was also present on the surface of EVTs that grew out from chorionic villous explants cultured under 20% O2.	Oxygen	128-130	C-C motif chemokine receptor 1	Homo sapiens	10-14
14530297-10	2003	By contrast, CCR1 was scarcely expressed on EVTs that grew out from villous explants cultured in 1% O2, indicating that a relatively high oxygenic environment is needed to induce CCR1 expression.	Oxygen	100-102	C-C motif chemokine receptor 1	Homo sapiens	13-17
11029004-4	2000	Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr).	Oxygen	43-49	neuroglobin	Mus musculus	6-17
10993914-5	2000	Retinol served as a cofactor to augment the activation of both cRaf and PKC alpha by reactive oxygen, whereas the classical receptor-mediated pathway was unaffected by the presence or absence of retinol.	Oxygen	94-100	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	63-67
21439370-11	2011	Together, these results indicate that ROS-induced separation of GDI from RhoA leads to RhoA activation with oxygen toxicity.	Oxygen	108-114	ras homolog family member A	Mus musculus	87-91
14631906-4	2003	Beta-2 agonists should always be given with oxygen in order to prevent the decrease in oxygen saturation due to the increase of blood flow in relatively poor ventilated areas of the lung.	Oxygen	44-50	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
21415262-3	2011	Oxygen consumption and fat oxidation in aged SAMP1 were lower by 19% and 22%, respectively.	Oxygen	0-6	transmembrane protein 201	Mus musculus	45-50
14631906-4	2003	Beta-2 agonists should always be given with oxygen in order to prevent the decrease in oxygen saturation due to the increase of blood flow in relatively poor ventilated areas of the lung.	Oxygen	87-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
14631906-5	2003	With the exception of hypoxemic patients who also need oxygen, the administration of beta-2 agonists using metered-dose inhalers with a holding chamber was found to be as effective as administration with nebulizers, and in some studies, even more effective and safer.	Oxygen	55-61	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-91
14749938-2	2003	We hypothesized that early expression of the proinflammatory cytokine, tumor necrosis factor alpha (TNFalpha), would be followed by later expression of the downstream chemokine, Grobeta, in the oxygen-injured newborn lung.	Oxygen	194-200	permeability factor 2	Oryctolagus cuniculus	178-185
10988074-5	2000	While this conformation allows endoperoxide formation between C-11 and C-9, it also implies that a subsequent conformational rearrangement must occur to allow formation of the C-8/C-12 bond and to position C-15 for attack by a second molecule of oxygen.	Oxygen	246-252	homeobox C8	Homo sapiens	176-179
10988181-0	2000	Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning.	Oxygen	122-128	spermine oxidase	Homo sapiens	98-101
10988181-1	2000	BACKGROUND: Because of the spectrum of intrapulmonary vascular dilation that characterizes hepatopulmonary syndrome (HPS), PaO(2) while breathing 100% oxygen varies.	Oxygen	151-157	spermine oxidase	Homo sapiens	123-126
10988181-8	2000	Seven patients (28%) had additional nonvascular pulmonary abnormalities and lower PaO(2) on 100% oxygen (215+/-133 mm Hg vs 391+/-137 mm Hg; p&lt;0.007).	Oxygen	97-103	spermine oxidase	Homo sapiens	82-85
10988181-12	2000	HPS patients with additional nonvascular pulmonary abnormalities exhibited lower PaO(2) on 100% oxygen.	Oxygen	96-102	spermine oxidase	Homo sapiens	81-84
14749938-6	2003	Grobeta mRNA expression in rabbit lung samples increased with oxygen exposure until day 8, then returned toward baseline levels.	Oxygen	62-68	permeability factor 2	Oryctolagus cuniculus	0-7
21315144-9	2011	The dependence of CYP activity on oxygen concentration was also observed.	Oxygen	34-40	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	18-21
14664825-3	2003	Neuronal cell death induced by a 4-h exposure to hypoxia (0.1% O(2)) was apoptotic, as shown by TUNEL staining and assays monitoring DNA strand breaks and caspase-3/7 activity.	Oxygen	63-67	caspase 3	Rattus norvegicus	155-164
21276436-5	2011	Cytotoxicity was attributed to increased NADH levels caused by CH(3)OH metabolism, catalyzed by ADH1, resulting in reductive stress, which reduced and released ferrous iron from Ferritin causing oxygen activation.	Oxygen	195-201	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	96-100
10969034-4	2000	Exposure to 1% O(2) led to a time-dependent significant rise of Tie2 protein levels in human coronary microvascular endothelial cells (HCMECs) and dermal microvascular ECs (HMEC-1) (3.2- and 2.5-fold within 24 hours), which was reversible after reoxygenation, and induced a less marked increase in human umbilical vein ECs (HUVECs; 1.7-fold).	Oxygen	15-19	TEK receptor tyrosine kinase	Homo sapiens	64-68
10969034-5	2000	Hypoxia-conditioned medium and D-deoxyglucose did not change Tie2 expression, but desferrioxamine and cobalt, which are known to mimic hypoxia-sensing mechanisms, induced Tie2 at ambient oxygen tensions.	Oxygen	187-193	TEK receptor tyrosine kinase	Homo sapiens	171-175
14551528-1	2003	PURPOSE: Nitric oxide formation by nitric oxide synthase (NOS) has been implicated in vascular injury and retinal neovascularization during oxygen-induced retinopathy.	Oxygen	140-146	nitric oxide synthase 1, neuronal	Mus musculus	35-56
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Oxygen	110-116	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	278-285
14499631-8	2003	These results reveal differences in tumor and normal cell responses to changes in ambient oxygen tension and show that MnSOD activity is inducible when an appropriate stimulus is applied.	Oxygen	90-96	superoxide dismutase 2	Homo sapiens	119-124
10950858-7	2000	It is concluded that reactive oxygen intermediates are implicated in the decrease of H(INFLA) P450 content and activity induced by 4 h of exposure to RS(INFLA) or HS(INF).	Oxygen	30-36	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	94-98
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Oxygen	110-116	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	287-294
10924349-2	2000	We demonstrate that in vitro the Na(+)/K(+)-ATPase, a non heme-protein, is able to disproportionate H(2)O(2) catalatically into dioxygen and water, as well as C(40) catalase.	Oxygen	128-136	dynein axonemal heavy chain 8	Homo sapiens	44-50
11048955-2	2000	In the case of RNase A, small thio-effects of the nonbridging oxygens have been invoked in favor of the classical mechanism.	Oxygen	62-69	ribonuclease A family member 1, pancreatic	Homo sapiens	15-22
14526232-6	2003	In response to hyperbaric oxygen (HBO2) at 5 ATA, WT and nNOS-/- mice showed decreases in rCBF over 30 minutes, but eNOS-/- mice did not.	Oxygen	26-32	nitric oxide synthase 1, neuronal	Mus musculus	57-61
14526232-6	2003	In response to hyperbaric oxygen (HBO2) at 5 ATA, WT and nNOS-/- mice showed decreases in rCBF over 30 minutes, but eNOS-/- mice did not.	Oxygen	26-32	CCAAT/enhancer binding protein zeta	Rattus norvegicus	90-94
12742082-0	2003	GDNF pre-treatment aggravates neuronal cell loss in oxygen-glucose deprived hippocampal slice cultures: a possible effect of glutamate transporter up-regulation.	Oxygen	52-58	glial cell derived neurotrophic factor	Rattus norvegicus	0-4
21434664-1	2011	An assaying method of cytochrome P450 (P450 or CYP) monooxygenase activities for toxicological evaluation of drugs and environmental pollutants was developed by immobilizing P450 on an oxygen sensoring layer.	Oxygen	56-62	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-50
15369351-1	2003	The direct addition of a proton to a carbonyl oxygen in an eta2-enone complex of palladium and platinum led to the quantitative formation of eta3-1-hydroxyallyl complexes of palladium and platinum, of which X-ray diffraction analysis showed typical eta3-allyl structure.	Oxygen	46-52	DNA polymerase iota	Homo sapiens	59-63
10901713-1	2000	Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea.	Oxygen	167-169	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	79-117
12637268-9	2003	Instead, the molybdenum center of XOR is posttranslationally inactivated by oxygen metabolites in "normal" (21% O2) cell culture atmosphere.	Oxygen	76-82	xanthine dehydrogenase	Homo sapiens	34-37
21434761-10	2011	RESULTS: Sox9, aggrecan, and collagen type 2 RNA expression increased with reduced oxygen.	Oxygen	83-89	SRY-box transcription factor 9	Homo sapiens	9-13
12637268-9	2003	Instead, the molybdenum center of XOR is posttranslationally inactivated by oxygen metabolites in "normal" (21% O2) cell culture atmosphere.	Oxygen	112-114	xanthine dehydrogenase	Homo sapiens	34-37
10920253-10	2000	The unique properties of the hydroxylase reaction catalyzed by P450(SPalpha), where an oxygen atom of hydrogen peroxide but not of molecular oxygen is utilized and incorporated into a fatty acid at its alpha position, is possibly related with such a specific heme environment of this P450.	Oxygen	87-93	CD5 molecule like	Homo sapiens	63-75
10920253-10	2000	The unique properties of the hydroxylase reaction catalyzed by P450(SPalpha), where an oxygen atom of hydrogen peroxide but not of molecular oxygen is utilized and incorporated into a fatty acid at its alpha position, is possibly related with such a specific heme environment of this P450.	Oxygen	141-147	CD5 molecule like	Homo sapiens	63-75
21604493-1	2011	This paper is aimed to observe the hepatocyte growth factor (HGF) loading and delivery ability of polylactic acid and oxygen carboxymethylated chitosan copolyer nanoparticles (PLA-O-CMC NPs).	Oxygen	118-124	hepatocyte growth factor	Homo sapiens	35-59
10936615-0	2000	Synthesis of 6-oxy functionalized campest-4-en-3-ones: efficient hydroperoxidation at C-6 of campest-5-en-3-one with molecular oxygen and silica gel.	Oxygen	127-133	complement C6	Homo sapiens	86-89
10936615-3	2000	Treatment of 7 with silica gel under an oxygen atmosphere in ethyl ether at room temperature produced efficient hydroperoxidation at the C-6 position to give 6alpha-hydroperoxycampest-4-en-3-one and 6beta-hydroperoxycampest-4-en-3-one in 34% and 49% yields, respectively.	Oxygen	40-46	complement C6	Homo sapiens	137-140
10936615-5	2000	This provided the first example of the practical use of hydroperoxidation at C-6 of a Delta(5(6))-unsaturated 3-oxo-steroid with molecular oxygen and silica gel.	Oxygen	139-145	complement C6	Homo sapiens	77-80
14565620-8	2003	Recombinant exogenous VEGF, as well as hypoxic stimulation with CoCl2 or 10% O2, significantly increased the length and number of outgrowing tubes in TCDD cultures, and this stimulation was prevented by a VEGF neutralizing antibody.	Oxygen	77-79	vascular endothelial growth factor A	Gallus gallus	205-209
21604493-1	2011	This paper is aimed to observe the hepatocyte growth factor (HGF) loading and delivery ability of polylactic acid and oxygen carboxymethylated chitosan copolyer nanoparticles (PLA-O-CMC NPs).	Oxygen	118-124	hepatocyte growth factor	Homo sapiens	61-64
12626345-4	2003	Expression of bFGF in the lung was significantly reduced at the end of the 7-day exposure to 95% O2 and was increased after 3 days of recovery in air.	Oxygen	97-99	fibroblast growth factor 2	Rattus norvegicus	14-18
21193393-8	2011	This suggests that the NEDD8 effect is concerned with reactive oxygen species driven from mitochondria rather than with the prolyl hydroxylase (PHD)/VHL-dependent oxygen-sensing system.	Oxygen	63-69	NEDD8 ubiquitin like modifier	Homo sapiens	23-28
12626345-6	2003	We hypothesized that the increase in bFGF after removal from 95% O2, acting through the FGF-R1, would be critical for compensatory growth.	Oxygen	65-67	fibroblast growth factor 2	Rattus norvegicus	37-41
12744702-1	2003	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin-dependent enzyme that catalyzes the hydroxylation of L-phenylalanine (L-Phe) to L-tyrosine using dioxygen as an additional substrate.	Oxygen	154-162	phenylalanine hydroxylase	Homo sapiens	0-25
10878820-2	2000	New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.	Oxygen	139-145	von Hippel-Lindau tumor suppressor	Homo sapiens	27-31
20851096-9	2011	Catalytic turnover of P450(cin) with either of these alternative substrates (camphane or cinane) revealed that in the absence of the ethereal oxygen there was still a significant amount of coupling of the NADPH-reducing equivalents to the formation of oxidised product.	Oxygen	142-148	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	22-26
10856310-8	2000	At baseline oxygen significantly improved SWT (mean difference 27.3 m (95% CI 14.7 to 39.8) and dyspnoea (-0.68 (95% CI -1.05 to -0.31)) compared with placebo air.	Oxygen	12-18	dynein axonemal assembly factor 1	Homo sapiens	42-45
12744702-1	2003	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin-dependent enzyme that catalyzes the hydroxylation of L-phenylalanine (L-Phe) to L-tyrosine using dioxygen as an additional substrate.	Oxygen	154-162	phenylalanine hydroxylase	Homo sapiens	27-30
20851096-9	2011	Catalytic turnover of P450(cin) with either of these alternative substrates (camphane or cinane) revealed that in the absence of the ethereal oxygen there was still a significant amount of coupling of the NADPH-reducing equivalents to the formation of oxidised product.	Oxygen	142-148	pyridoxal phosphatase	Homo sapiens	27-30
20851096-11	2011	Thus, it still remains unclear how dioxygen activation in the catalytic turnover of cineole by P450(cin) is controlled.	Oxygen	35-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	95-99
12926365-5	2003	Addition of .OH to phenol gives rise to dihydroxycyclohexadienyl radicals which add dioxygen and eliminate HO2.	Oxygen	84-92	heme oxygenase 2	Homo sapiens	107-110
12727869-4	2003	We identified POS5 in a S.cerevisiae genetic screen for hyperoxia-sensitive mutants, or cells that cannot survive in 100% oxygen.	Oxygen	122-128	NADH kinase	Saccharomyces cerevisiae S288C	14-18
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	12-18	egl-9 family hypoxia inducible factor 2	Homo sapiens	62-66
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	96-102	egl-9 family hypoxia inducible factor 2	Homo sapiens	62-66
20851096-11	2011	Thus, it still remains unclear how dioxygen activation in the catalytic turnover of cineole by P450(cin) is controlled.	Oxygen	35-43	pyridoxal phosphatase	Homo sapiens	84-87
21499589-6	2011	Oxygen is recommended for COPD patients with resting hypoxemia, but its use for the targeted management of dyspnea in this setting should be reserved for patients who receive symptomatic benefit.	Oxygen	0-6	COPD	Homo sapiens	26-30
20809181-7	2011	WB and microscopy analyses of both IMV and optic nerves showed that the Inhibitor of F(1) (IF(1)), a small protein that binds the F(1) moiety in low pH when of oxygen supply is impaired, is expressed in myelin sheath.	Oxygen	160-166	ATP synthase inhibitory factor subunit 1	Homo sapiens	72-89
20809181-7	2011	WB and microscopy analyses of both IMV and optic nerves showed that the Inhibitor of F(1) (IF(1)), a small protein that binds the F(1) moiety in low pH when of oxygen supply is impaired, is expressed in myelin sheath.	Oxygen	160-166	ATP synthase inhibitory factor subunit 1	Homo sapiens	91-96
21215271-5	2011	Furthermore, both GPx7 and GPx8 interact with Ero1alpha in vivo, and GPx7 significantly increases oxygen consumption by Ero1alpha in vitro.	Oxygen	98-104	glutathione peroxidase 7	Homo sapiens	69-73
20980551-10	2011	Still, the specific disruption of the PHD1 gene is known to induce hypoxic tolerance, without angiogenesis and erythrocytosis, by reprogramming basal oxygen metabolism with an attendant decreased oxidative stress in hypoxic mitochondria.	Oxygen	150-156	egl-9 family hypoxia inducible factor 2	Homo sapiens	38-42
21045753-7	2011	The MIF -173*C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95% CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03).	Oxygen	188-194	macrophage migration inhibitory factor	Homo sapiens	4-7
21598682-2	2011	Activation of TRPM8 with menthol even in thermoneutral conditions produces an increase in oxygen consumption and a decrease in respiratory coefficient, which may suggest enhanced non-shivering thermogenesis and lipolysis.	Oxygen	90-96	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	14-19
21059898-8	2011	In mouse oxygen-induced retinopathy model, G-CSF significantly reduced vascular obliteration (P &lt; .01) and neovascular tuft formation (P &lt; .01).	Oxygen	9-15	colony stimulating factor 3 (granulocyte)	Mus musculus	43-48
21169549-2	2011	In transformed cells, MIF was shown to modulate and to be modulated via the oxygen-sensitive transcription factor hypoxia-inducible factor (HIF)-1.	Oxygen	76-82	macrophage migration inhibitory factor	Homo sapiens	22-25
20802534-2	2011	Although the involvement of pVHL in oxygen sensing through targeting hypoxia-inducible factor-alpha subunits to ubiquitin-dependent proteolysis has been well documented, less is known about pVHL regulation under both normoxic and hypoxic conditions.	Oxygen	36-42	von Hippel-Lindau tumor suppressor	Homo sapiens	28-32
21677804-5	2011	We tried to implement this effect of oxygen in correlation with echocardiography in patients with TGA-VSD physiology where operability was in question.	Oxygen	37-43	T-box transcription factor 1	Homo sapiens	98-101
21677804-12	2011	CONCLUSION: Patients with TGA/VSD physiology with doubtful operability can be subjected to this method of determining operability using echocardiography after administering oxygen.	Oxygen	173-179	T-box transcription factor 1	Homo sapiens	26-29
20864514-11	2011	TAK1-(/)- mice consume more oxygen and produce more carbon dioxide than WT mice, suggesting increased energy expenditure.	Oxygen	28-34	mitogen-activated protein kinase kinase kinase 7	Mus musculus	0-4
21731450-4	2011	We speculated that cell-cell interaction is involved in the regulation of MMP-2 expression and activity at low oxygen level in vivo.	Oxygen	111-117	matrix metallopeptidase 2	Rattus norvegicus	74-79
21508652-0	2011	Netrin-1 overexpression in oxygen-induced retinopathy correlates with breakdown of the blood-retina barrier and retinal neovascularization.	Oxygen	27-33	netrin 1	Mus musculus	0-8
21508652-2	2011	We evaluate the expression of netrin-1 during retinal neovascularization in a murine model of oxygen-induced retinopathy.	Oxygen	94-100	netrin 1	Mus musculus	30-38
21228614-1	2011	Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes.	Oxygen	39-45	neuroglobin	Mus musculus	0-11
21228614-1	2011	Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes.	Oxygen	39-45	neuroglobin	Mus musculus	13-16
22164238-1	2011	BACKGROUND: Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain.	Oxygen	67-73	neuroglobin	Mus musculus	12-23
22164238-1	2011	BACKGROUND: Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain.	Oxygen	67-73	neuroglobin	Mus musculus	25-28
22164023-5	2011	Among the selected indices, the relative distribution of PLF to the total fluorescence area of SFS (Index II) exhibited the highest correlation coefficient with total organic carbon (TOC)-based biodegradability, which was even higher than those obtained with the traditional oxygen demand-based parameters.	Oxygen	275-281	PLF	Homo sapiens	57-60
20804862-2	2010	We previously reported that ventilation with 100% O2 increased PDE5 activity in pulmonary arteries (PAs) of pulmonary hypertension lambs (PPHN) more than in control lambs.	Oxygen	50-52	PDE5A	Ovis aries	63-67
20804862-6	2010	Similarly, catalase treatment of PPHN lambs ventilated with 100% O2 decreased PDE5 activity and increased cGMP in PA. We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN.	Oxygen	65-67	PDE5A	Ovis aries	78-82
20804862-6	2010	Similarly, catalase treatment of PPHN lambs ventilated with 100% O2 decreased PDE5 activity and increased cGMP in PA. We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN.	Oxygen	65-67	PDE5A	Ovis aries	144-148
20804862-6	2010	Similarly, catalase treatment of PPHN lambs ventilated with 100% O2 decreased PDE5 activity and increased cGMP in PA. We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN.	Oxygen	65-67	PDE5A	Ovis aries	144-148
21077091-2	2010	Herein, we present an unambiguous and rigorous theoretical analysis in order to explain why and how the oxygen vacancies affect the n-type semiconductors alpha-Fe(2)O(3) and Fe-doped SnO(2), in which they are both electronically and chemically transformed into a p-type semiconductor.	Oxygen	104-110	strawberry notch homolog 1	Homo sapiens	183-186
12595429-5	2003	The expression of Dps was significantly increased by exposure of P. gingivalis to atmospheric oxygen in an OxyR-dependent manner, indicating that it is regulated by the reactive oxygen species-regulating gene oxyR.	Oxygen	94-100	decaprenyl diphosphate synthase subunit 1	Homo sapiens	18-21
12595429-6	2003	The Dps-deficient mutants, including the dps single mutant and the ftn dps double mutant, showed no viability loss upon exposure to atmospheric oxygen for 6 h. In contrast to the wild type, however, these mutants exhibited the high susceptibility to hydrogen peroxide, thereby disrupting the viability.	Oxygen	144-150	decaprenyl diphosphate synthase subunit 1	Homo sapiens	4-7
12601060-1	2003	PURPOSE: Define a role for Fas-FasL in oxygen-induced retinopathy and explore the mechanism of pigment-epithelium-derived growth factor (PEDF) inhibition in this model.	Oxygen	39-45	Fas ligand (TNF superfamily, member 6)	Mus musculus	31-35
12601060-6	2003	RESULTS: Oxygen-induced retinopathy was significantly increased in FasL-defective gld mice compared with wild-type B6 animals.	Oxygen	9-15	Fas ligand (TNF superfamily, member 6)	Mus musculus	67-71
12601060-9	2003	CONCLUSIONS: Fas-FasL interactions regulate the extent of oxygen-induced retinal neovascularization.	Oxygen	58-64	Fas ligand (TNF superfamily, member 6)	Mus musculus	17-21
10858495-2	2000	We show that peroxynitrite can be produced by the action of a single enzyme, xanthine oxidoreductase (XOR), in the presence of inorganic nitrite, molecular oxygen and a reducing agent, such as pterin.	Oxygen	156-162	xanthine dehydrogenase	Homo sapiens	77-100
10858495-2	2000	We show that peroxynitrite can be produced by the action of a single enzyme, xanthine oxidoreductase (XOR), in the presence of inorganic nitrite, molecular oxygen and a reducing agent, such as pterin.	Oxygen	156-162	xanthine dehydrogenase	Homo sapiens	102-105
10830589-11	2000	These results suggest that GCSF activates the ability to generate active oxygen species by neutrophils and, thereby, enhances the anti-tumour effect of hyperthermia.	Oxygen	73-79	colony stimulating factor 3 (granulocyte)	Mus musculus	27-31
10766820-4	2000	Using homozygous null mice for the protein kinase C beta-isoform gene (PKCbeta null), PKCbeta is shown to be upstream of Egr-1 in this oxygen deprivation-mediated pathway for triggering procoagulant events.	Oxygen	135-141	protein kinase C, beta	Mus musculus	71-78
10766820-4	2000	Using homozygous null mice for the protein kinase C beta-isoform gene (PKCbeta null), PKCbeta is shown to be upstream of Egr-1 in this oxygen deprivation-mediated pathway for triggering procoagulant events.	Oxygen	135-141	protein kinase C, beta	Mus musculus	86-93
10766820-6	2000	Consistent with a central role for Egr-1 in hypoxia-induced expression of tissue factor, PKCbeta null mice subjected to oxygen deprivation displayed at most a minor elevation in Egr-1 transcripts, antigen, and intensity of the gel shift band by electrophoretic mobility shift assay, compared with normoxic animals.	Oxygen	120-126	protein kinase C, beta	Mus musculus	89-96
10766820-7	2000	These data firmly establish PKCbeta as a trigger for events leading to induction of Egr-1 and tissue factor under hypoxic conditions, and provide insight into a biologic cascade whereby oxygen deprivation recruits targets of PKCbeta and Egr-1, thereby amplifying the cellular response.	Oxygen	186-192	protein kinase C, beta	Mus musculus	28-35
10766820-7	2000	These data firmly establish PKCbeta as a trigger for events leading to induction of Egr-1 and tissue factor under hypoxic conditions, and provide insight into a biologic cascade whereby oxygen deprivation recruits targets of PKCbeta and Egr-1, thereby amplifying the cellular response.	Oxygen	186-192	protein kinase C, beta	Mus musculus	225-232
12553769-10	2003	At -0.58 V, the dissolved oxygen in solution was reduced to HO2-, resulting in light emission.	Oxygen	26-32	heme oxygenase 2	Homo sapiens	60-63
20473639-7	2010	Manganese-containing superoxide dismutase (MnSOD) activity was unaffected by oxygen tension, but was elevated in young confluent cultures as compared with cultures in log-phase growth.	Oxygen	77-83	superoxide dismutase 2	Homo sapiens	43-48
14753401-7	2003	Oxygen consumption gradually decreased from 4 to 10 h. CBF and MABP were all significantly increased (by 2.5-fold for CBF) (p &lt; 0.05).	Oxygen	0-6	CCAAT/enhancer binding protein zeta	Rattus norvegicus	55-58
14753401-7	2003	Oxygen consumption gradually decreased from 4 to 10 h. CBF and MABP were all significantly increased (by 2.5-fold for CBF) (p &lt; 0.05).	Oxygen	0-6	CCAAT/enhancer binding protein zeta	Rattus norvegicus	118-121
20473639-8	2010	MnSOD activity was significantly higher in senescent cultures than in early passage cultures and was also responsive to increased oxygen tension in senescent cultures.	Oxygen	130-136	superoxide dismutase 2	Homo sapiens	0-5
12775898-11	2003	Hct/viscosity ratio (Hct/eta), a proposed index of Hct"s positive influence on O2 transfer to tissues, was positively correlated to Wmax expressed as a percentage of theoretical values (r=0.487, p=0.02).	Oxygen	79-81	endothelin receptor type A	Homo sapiens	25-28
20798245-2	2010	We showed that activation of PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasing PDK2 activity and increasing PDH activity, accelerating oxygen consumption, and augmenting ATP synthesis.	Oxygen	187-193	pyruvate dehydrogenase kinase 2	Homo sapiens	105-109
12496216-2	2003	The tpx strain was clearly more sensitive than the parent strain to both oxygen and cumene hydroperoxide.	Oxygen	73-79	peroxiredoxin 2	Mus musculus	4-7
20635854-10	2010	A region of interest-based approach was used to evaluate fMR imaging blood oxygen level-dependent activation level and asymmetry in the SMA.	Oxygen	75-81	survival of motor neuron 1, telomeric	Homo sapiens	136-139
12472784-2	2003	Angiotensin II (Ang II) acting on Type I receptors (AT1-R) causes renal oxidative stress and functional nitric oxide (NO) deficiency that could enhance O2 usage.	Oxygen	152-154	angiotensin II receptor, type 1a	Rattus norvegicus	52-57
12472784-12	2003	CONCLUSIONS: The reduced pO2 in outer and inner cortex, and inefficient utilization of O2 for Na+ transport in the SHR kidney can be ascribed to the effects of AT1-R, largely independent of blood pressure.	Oxygen	26-28	angiotensin II receptor, type 1a	Rattus norvegicus	160-165
21287783-7	2010	RESULTS: In the mini-swine with immune hepatic injury induced by ConA, the tongue color showed cyanotic color, microvascular perfusion in the liver and the tongue, and partial pressure of oxygen in the tongue tissue significantly decreased; and the microcirculatory perfusion of the tongue was significantly correlated with that of the liver and the HIS color spatial value of the tongue; Serum TNF-alpha content significantly increased.	Oxygen	188-194	CONA	Sus scrofa	65-69
20813571-11	2010	We speculate that re-oxygenation immediately reverses hypoxia effect probably due to oxygen tension-dependent reversibility of PAFr activation and suggest that exposure of the neonate to prolonged state of hypoxia will vilify oxygen exchange capacity of the neonatal lungs.	Oxygen	21-27	platelet activating factor receptor	Homo sapiens	127-131
12687273-4	2003	HeLa cells showed inducible expression of CA IX in vitro by hypoxia (0.1% O2) and various hypoxia mimicking agents (Co2+, Ni2+, Mn2+, desferrioxamine, o-phenanthroline and Na2S2O4).	Oxygen	74-76	carbonic anhydrase 9	Homo sapiens	42-47
12806184-8	2003	Our data thus indicate an important role of CYP2B1 in PAN-induced cytotoxicity by serving as a site of reactive oxygen metabolite generation and a significant source of catalytic iron.	Oxygen	112-118	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	44-50
12451424-1	2002	The diffusion of molecular oxygen or its isosteric analogue, carbon monoxide, from the surface of myoglobin to its deeply imbedded haem appears to represent one of the simplest protein functions.	Oxygen	27-33	myoglobin	Physeter catodon	98-107
12486081-3	2002	Although the functional role of this novel member of the globin family remains unclear, neuroglobin contains a heme-binding domain and may participate in diverse processes such as oxygen transport, oxygen storage, nitric oxide detoxification, or modulation of terminal oxidase activity.	Oxygen	180-186	neuroglobin	Mus musculus	88-99
12486081-3	2002	Although the functional role of this novel member of the globin family remains unclear, neuroglobin contains a heme-binding domain and may participate in diverse processes such as oxygen transport, oxygen storage, nitric oxide detoxification, or modulation of terminal oxidase activity.	Oxygen	198-204	neuroglobin	Mus musculus	88-99
12213810-4	2002	The most dramatic loss of antigenicity was seen with the 17-kDa glycine decarboxylase complex (GDC) H-protein, which was correlated with the loss of glycine-dependent O2 consumption.	Oxygen	167-169	glycine decarboxylase	Homo sapiens	64-85
20813571-11	2010	We speculate that re-oxygenation immediately reverses hypoxia effect probably due to oxygen tension-dependent reversibility of PAFr activation and suggest that exposure of the neonate to prolonged state of hypoxia will vilify oxygen exchange capacity of the neonatal lungs.	Oxygen	85-91	platelet activating factor receptor	Homo sapiens	127-131
21290840-7	2010	(4) In acupoints, the oxygen partial pressure in Cx43 WT mice was significantly higher than that in Cx43 HT mice (all P &lt; 0.05), while in the corresponding non-acupoints, this difference had no statistically significant (all P &gt; 0.05).	Oxygen	22-28	gap junction protein, alpha 3	Mus musculus	49-53
12234896-8	2002	Administration of 92% O(2) + 8% CO(2) significantly increased SBP, MAP, and PR (p &lt;0.001 each, versus baseline), whereas the other gas mixtures had little effect on systemic haemodynamics.	Oxygen	22-26	selenium binding protein 1	Homo sapiens	62-65
12239605-3	2002	This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption.	Oxygen	80-86	hypocretin	Mus musculus	62-68
21095582-1	2010	The mTOR complex-1 (mTORC1) coordinates cell growth and metabolism, acting as a restriction point under stress conditions such as low oxygen tension (hypoxia).	Oxygen	134-140	CREB regulated transcription coactivator 1	Mus musculus	20-26
12239605-6	2002	Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls.	Oxygen	46-52	hypocretin	Mus musculus	0-6
12352313-5	2002	In multiple regression analyses, the major determinants of peak oxygen uptake (VO max) were age (-), sex (male), peak exercise systolic BP (+) and post-exercise BNP (-).	Oxygen	64-70	natriuretic peptide B	Homo sapiens	161-164
20705920-7	2010	Compared with age-matched control mice, retinal apelin expression was dramatically increased during the hypoxic phase in oxygen-induced retinopathy model mice.	Oxygen	121-127	apelin	Mus musculus	48-54
12214901-8	2002	Multiple regression analysis revealed significant correlations between CPK and oxygen consumption (beta .37, P &lt; .01) in 32 individuals who performed the exercise test.	Oxygen	79-85	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	71-74
20705920-9	2010	Apelin deficiency hardly induced hypoxia-induced retinal angiogenesis despite the upregulation of VEGF and erythropoietin mRNA in oxygen-induced retinopathy model mice.	Oxygen	130-136	apelin	Mus musculus	0-6
20637870-6	2010	The present study provides the first evidence supporting the hypothesis that autophagy and apoptosis can be differentially induced by 4-HPR under different oxygen conditions; mediated by HIF-1alpha, 4-HPR-induced autophagy under hypoxia confers a survival advantage to HeLa cells, protects them from 4-HPR-induced death signals, and thus contributes to their hypoxia-induced resistance to this agent.	Oxygen	156-162	haptoglobin-related protein	Homo sapiens	136-139
12349904-4	2002	Mg2+ deficiency results in progressive vasoconstriction of the coronary vessels leading to a marked reduction in oxygen and nutrient delivery to the cardiac myocytes.	Oxygen	113-119	mucin 7, secreted	Homo sapiens	0-3
20637870-6	2010	The present study provides the first evidence supporting the hypothesis that autophagy and apoptosis can be differentially induced by 4-HPR under different oxygen conditions; mediated by HIF-1alpha, 4-HPR-induced autophagy under hypoxia confers a survival advantage to HeLa cells, protects them from 4-HPR-induced death signals, and thus contributes to their hypoxia-induced resistance to this agent.	Oxygen	156-162	haptoglobin-related protein	Homo sapiens	201-204
12121862-6	2002	Our data suggest that low O(2) upregulates Flk-1 expression in embryonic aorta in vitro and renders it more responsive to VEGF.	Oxygen	26-30	kinase insert domain protein receptor	Mus musculus	43-48
20637870-6	2010	The present study provides the first evidence supporting the hypothesis that autophagy and apoptosis can be differentially induced by 4-HPR under different oxygen conditions; mediated by HIF-1alpha, 4-HPR-induced autophagy under hypoxia confers a survival advantage to HeLa cells, protects them from 4-HPR-induced death signals, and thus contributes to their hypoxia-induced resistance to this agent.	Oxygen	156-162	haptoglobin-related protein	Homo sapiens	201-204
20921441-10	2010	Accordingly, O(2) consumption in isolated heart muscle strips was decreased in nNOS-overexpressing nNOS(+)/alphaMHC-tTA(+) mice already under resting conditions.	Oxygen	13-17	nitric oxide synthase 1, neuronal	Mus musculus	79-83
12154057-0	2002	Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3"-kinase.	Oxygen	8-14	carbonic anhydrase 9	Homo sapiens	64-88
12154057-8	2002	The mechanism controlling CAIX expression in dense cultures is, however, dependent on lowered O(2) tension because stirring abrogates induction of CAIX expression.	Oxygen	94-98	carbonic anhydrase 9	Homo sapiens	26-30
12214662-1	2002	Kinetic studies carried out over the past three decades, primarily with purified pig liver flavin-containing monooxygenase (FMO1), demonstrated that the mechanism of this flavoenzyme was distinctly different from other widely studied flavin-dependent monooxygenases in that reduction of O2 by nicotinamide-adenine-dinucleotide-phosphate reduced (NADPH) occurred before the addition of the xenobiotic substrate.	Oxygen	287-289	flavin containing dimethylaniline monoxygenase 1	Sus scrofa	124-128
20921441-10	2010	Accordingly, O(2) consumption in isolated heart muscle strips was decreased in nNOS-overexpressing nNOS(+)/alphaMHC-tTA(+) mice already under resting conditions.	Oxygen	13-17	nitric oxide synthase 1, neuronal	Mus musculus	99-103
20622120-5	2010	Exposing HPASMC to 1% oxygen for 72 h increased Nox4 gene expression and H(2)O(2) production, both of which were reduced by treatment with rosiglitazone during the last 24 h of hypoxia exposure or by treatment with small interfering RNA (siRNA) to Nox4.	Oxygen	22-28	NADPH oxidase 4	Homo sapiens	48-52
12101228-2	2002	Here, we show that nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein (VHL) is required for oxygen-dependent ubiquitination and degradation of the alpha subunits of hypoxia-inducible factor (HIF-alpha).	Oxygen	123-129	von Hippel-Lindau tumor suppressor	Homo sapiens	102-105
12101228-3	2002	VHL engages in a constitutive transcription-sensitive nuclear-cytoplasmic shuttle unaffected by oxygen tension or levels of nuclear substrate HIF-alpha.	Oxygen	96-102	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
12162174-6	2002	This is consistent with the involvement of the VHL protein in multiprotein complexes that degrade hypoxia-inducible factors dependent on cellular oxygen levels.	Oxygen	146-152	von Hippel-Lindau tumor suppressor	Homo sapiens	47-50
20622120-5	2010	Exposing HPASMC to 1% oxygen for 72 h increased Nox4 gene expression and H(2)O(2) production, both of which were reduced by treatment with rosiglitazone during the last 24 h of hypoxia exposure or by treatment with small interfering RNA (siRNA) to Nox4.	Oxygen	22-28	NADPH oxidase 4	Homo sapiens	248-252
12096915-4	2002	The enzyme phenylalanine hydroxylase (PheOH) catalyzes the hydroxylation of l-phenylalanine into l-tyrosine utilizing the cofactors (6R)-l-erythro-5,6,7,8 tetrahydrobiopterin (BH(4)) and molecular oxygen.	Oxygen	197-203	phenylalanine hydroxylase	Homo sapiens	11-36
20705330-9	2010	There was also a more distinct relationship between maximum chemical oxygen demand (COD(Mn)) and minimum pH in autumn runoff than in spring.	Oxygen	69-75	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	84-91
12056827-1	2002	The VHL protein (pVHL) is a component of an E3 ubiquitin ligase complex which is involved in the ubiquitination and degradation of the alpha subunits of HIF (hypoxia-inducible factor) in the presence of oxygen.	Oxygen	203-209	von Hippel-Lindau tumor suppressor	Homo sapiens	17-21
20577688-1	2010	For a mixed oxide-ion and electron conducting oxide, with oxygen vacancies (V(O)) and electrons (e") or holes (h ) as charge carriers, a flux of (V(O)) (J(i)) can in principle be driven, not only directly by its own electrochemical potential gradient (inverted Delta eta(i)), but also indirectly by that of electrons (inverted Delta eta(e)), and vice versa for the flux of electrons (J(e)).	Oxygen	58-64	endothelin receptor type A	Homo sapiens	267-270
12162728-9	2002	Ang-2 mRNA transcription is increased under reduced oxygen and the stability of Ang-1 mRNA is reduced under similar conditions.	Oxygen	52-58	angiopoietin 2	Homo sapiens	0-5
20577688-1	2010	For a mixed oxide-ion and electron conducting oxide, with oxygen vacancies (V(O)) and electrons (e") or holes (h ) as charge carriers, a flux of (V(O)) (J(i)) can in principle be driven, not only directly by its own electrochemical potential gradient (inverted Delta eta(i)), but also indirectly by that of electrons (inverted Delta eta(e)), and vice versa for the flux of electrons (J(e)).	Oxygen	58-64	endothelin receptor type A	Homo sapiens	333-336
10749833-3	2000	After 30 min of O(2) exposure at 3 and 4 ATA, rCBF decreased by 26-39% and by 37-43%, respectively, and was sustained for 75 min.	Oxygen	16-20	CCAAT/enhancer binding protein zeta	Rattus norvegicus	46-50
20427335-3	2010	Here, we sought to characterize the molecular mechanisms responsible for the O(2)-sensitive transcriptional induction of TGFbeta in murine CF and to test the significance of such findings in the infarcted myocardium in vivo using laser capture microdissection.	Oxygen	77-81	transforming growth factor, beta 1	Mus musculus	121-128
10692397-0	2000	Coordinate copper- and oxygen-responsive Cyc6 and Cpx1 expression in Chlamydomonas is mediated by the same element.	Oxygen	23-29	uncharacterized protein	Chlamydomonas reinhardtii	41-45
12005492-0	2002	Photolytic reactions of subvalent aluminum(I) halides in the presence of dioxygen: generation and characterization of the peroxo species XAlO(2) and XAl(mu-O)(2)AlX (X = F, Cl, Br).	Oxygen	73-81	hematopoietic SH2 domain containing	Homo sapiens	161-164
11970939-1	2002	BACKGROUND AND AIMS: Increased generation of reactive oxygen species and mitochondrial dysfunction may underlie the pathophysiology of Friedreich"s ataxia, the most common inherited ataxia, due to GAA expansion in a gene coding for a mitochondrial protein (frataxin), implicated in the regulation of iron metabolism.	Oxygen	54-60	alpha glucosidase	Homo sapiens	197-200
20427335-8	2010	Knockdown of Fra-2 significantly blunted O(2)-induced expression of TGFbeta1 as well as TGFbeta3 in CF.	Oxygen	41-45	transforming growth factor, beta 1	Mus musculus	68-76
11970939-1	2002	BACKGROUND AND AIMS: Increased generation of reactive oxygen species and mitochondrial dysfunction may underlie the pathophysiology of Friedreich"s ataxia, the most common inherited ataxia, due to GAA expansion in a gene coding for a mitochondrial protein (frataxin), implicated in the regulation of iron metabolism.	Oxygen	54-60	frataxin	Homo sapiens	257-265
20601390-6	2010	Angiopoietin-2, but not Ang-1, sTie2, and VEGF correlated with cardiac index (r = -0.53, P &lt; 0.001), pulmonary vascular resistance (PVR) (r= 0.60, P &lt; 0.001), and mixed venous oxygen saturation (SvO(2)) (r= -0.63, P &lt; 0.001).	Oxygen	182-188	angiopoietin 2	Homo sapiens	0-14
12062208-0	2002	New artificial oxygen carriers made of pegulated polymerised pyridoxylated porcine haemoglobin (P(4)Hb).	Oxygen	15-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	96-102
11988606-10	2002	CONCLUSIONS: In patients with cerebrovascular disease, neural stimulation may induce variable changes in rCBF and rCMRO2 according to the baseline perfusion and oxygen metabolism.	Oxygen	161-167	CCAAT/enhancer binding protein zeta	Rattus norvegicus	105-109
10724113-9	2000	This tight correlation for cerebral oxygen delivery in vivo is supported by a recent model where the consequence of a changing effective diffusivity of the capillary bed for oxygen, D, has been hypothetically shown to be linked to alterations in CMRO2 and CBF.	Oxygen	36-42	CCAAT/enhancer binding protein zeta	Rattus norvegicus	256-259
10724113-9	2000	This tight correlation for cerebral oxygen delivery in vivo is supported by a recent model where the consequence of a changing effective diffusivity of the capillary bed for oxygen, D, has been hypothetically shown to be linked to alterations in CMRO2 and CBF.	Oxygen	174-180	CCAAT/enhancer binding protein zeta	Rattus norvegicus	256-259
10760143-7	2000	Examination of PAU gene expression in rox1Delta and tup1Delta strains indicates that PAU repression by oxygen is mediated by an unknown, haem-dependent pathway, which does not involve the Rox1p anaerobic repressor but requires Tup1p.	Oxygen	103-109	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	227-232
20622065-4	2010	Here we report mapping of the fadH promoter and document its complex regulation by three independent regulators, the fatty acid degradation FadR repressor, the oxygen-responsive ArcA-ArcB two-component system, and the cyclic AMP receptor protein-cyclic AMP (CRP-cAMP) complex.	Oxygen	160-166	arginine deiminase	Escherichia coli	178-182
10652449-5	2000	The extensive microglial expression of COX-2, that is likely to be followed by a sustained enzymatic activity leading to the generation of prostaglandins as well as of oxygen free radicals, might have important effects on chronic neurodegeneration.	Oxygen	168-174	prostaglandin-endoperoxide synthase 2	Mus musculus	39-44
10719243-0	2000	Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway.	Oxygen	23-29	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	33-60
12020135-5	2002	Based on crystal structures and the fact that the P450(BM-3) F87A mutant produces a large isotope in contrast to the native enzyme, we propose that phenylalanine 87 is responsible for hindering substrate access to the active oxygen species for nonnative substrates.	Oxygen	225-231	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-59
11855848-0	2002	Mga2p is a putative sensor for low temperature and oxygen to induce OLE1 transcription in Saccharomyces cerevisiae.	Oxygen	51-57	Mga2p	Saccharomyces cerevisiae S288C	0-5
11855848-6	2002	These observations suggest that low-temperature and hypoxic signal transduction pathways share some components, and Mga2p is the first identified eukaryotic sensor for low temperature and oxygen.	Oxygen	188-194	Mga2p	Saccharomyces cerevisiae S288C	116-121
11888972-7	2002	In patients, ELF PTHrP concentration correlated positively with the PaO(2)/fraction of inspired oxygen ratio (r = 0.53; p = 0.005), and negatively with lung injury score (r = - 0.44; p = 0.02), radiologic score (r = - 0.40; p = 0.04), and BAL albumin concentration (r = - 0.42; p = 0.02).	Oxygen	96-102	parathyroid hormone like hormone	Homo sapiens	17-22
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	Oxygen	18-24	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	29-32
10701804-0	2000	Epithelial inclusions in association with mucin ball development in high-oxygen permeability hydrogel lenses.	Oxygen	73-79	LOC100508689	Homo sapiens	42-47
10784123-5	2000	Cell damage induced by deprivation of oxygen and glucose was prevented by calcium-free medium or by non-N-methyl-D-aspartate glutamate receptor (GluR) antagonists, such as 6-cyano-7-nitroquinoxaline-2,3-dione or LY293558, but not by the voltage-dependent calcium channel blocker, nimodipine, or by the N-methyl-D-aspartate GluR antagonist, MK-801.	Oxygen	38-44	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	104-143
20597513-4	2010	FAK1 catalyzed the betagamma-bridge:beta-nonbridge positional oxygen exchange of [gamma-(18)O(4)]ATP in the presence of 1 mM [gamma-(18)O(4)]ATP and 1.5 mM FAK-tide with a progressive time course which was commensurate with catalysis, resulting in a rate of exchange to catalysis of k(x)/k(cat) = 0.14 +/- 0.01.	Oxygen	62-68	protein tyrosine kinase 2	Homo sapiens	0-4
11866672-8	2002	Long-term oxygen therapy is also among the most costly interventions in terms of total money spent on direct medical costs for COPD treatment, although it is probably cost-effective because of its positive impact on rates of mortality.	Oxygen	10-16	COPD	Homo sapiens	127-131
11866672-9	2002	In fact, oxygen therapy is the only intervention to date that has been shown to decrease death rates due to COPD.	Oxygen	9-15	COPD	Homo sapiens	108-112
11392808-6	2000	High risk of development of 3rd stage ROP was observed in neonates born before 28th week of gestation, weighing at birth less than 1000 g. The significant risk factors were also the asphyxia, duration of ventillation exceeding 30 days and oxygen therapy longer than 40 days.	Oxygen	239-245	opsin 1, long wave sensitive	Homo sapiens	38-41
20597513-4	2010	FAK1 catalyzed the betagamma-bridge:beta-nonbridge positional oxygen exchange of [gamma-(18)O(4)]ATP in the presence of 1 mM [gamma-(18)O(4)]ATP and 1.5 mM FAK-tide with a progressive time course which was commensurate with catalysis, resulting in a rate of exchange to catalysis of k(x)/k(cat) = 0.14 +/- 0.01.	Oxygen	62-68	protein tyrosine kinase 2	Homo sapiens	0-3
12474290-4	2002	She was diagnosed as carbon monoxide intoxication and treated with hyperbaric oxygen from March 1.	Oxygen	78-84	membrane associated ring-CH-type finger 1	Homo sapiens	90-97
20675543-5	2010	These studies have indicated that activation of key transcription factors (MEF2, NFAT and Sp1) and co-activators (PGC-1alpha) by locomotor activity, differential intracellular calcium fluxes and low intracellular oxygen tension collectively regulate myoglobin expression.	Oxygen	213-219	myocyte enhancer factor 2A	Homo sapiens	75-79
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Oxygen	174-180	uncharacterized protein	Chlamydomonas reinhardtii	42-46
10794846-7	2000	Overall, these results demonstrate that chronically elevated reactive oxygen species in Alzheimer"s disease cybrid cells are associated with a more robust phosphoinositide signaling system, but lower signaling to activation of AP-1.	Oxygen	70-76	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	227-231
20001586-3	2010	Trans-sodium crocetinate (TSC) has been shown to transiently increase oxygen to hypoxic brain tumors.	Oxygen	70-76	solute carrier family 12 member 3	Rattus norvegicus	26-29
10898220-3	2000	We examined the expression of hypoxia-inducible factor 1 (HIF-1), a potent transcriptional regulator of oxygen-dependent genes such as vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-beta), a potentially HIF-1-regulated scarring cytokine, on fetal and adult responses to wounding.	Oxygen	104-110	vascular endothelial growth factor A	Ovis aries	135-169
11795785-1	2002	Stable films of dimyristoylphosphatidylcholine and M. tuberculosis catalase-peroxidase (KatG), several peroxidases, myoglobin, and catalase showed reversible FeIII/FeII voltammetry on pyrolytic graphite electrodes and catalytic current for hydrogen peroxide and oxygen.	Oxygen	262-268	catalase-3	Glycine max	67-75
11795785-1	2002	Stable films of dimyristoylphosphatidylcholine and M. tuberculosis catalase-peroxidase (KatG), several peroxidases, myoglobin, and catalase showed reversible FeIII/FeII voltammetry on pyrolytic graphite electrodes and catalytic current for hydrogen peroxide and oxygen.	Oxygen	262-268	catalase-3	Glycine max	131-139
11795785-5	2002	KatG catalyzed the electrochemical reduction of oxygen more efficiently than catalase and CcP but less efficiently than the other peroxidases.	Oxygen	48-54	catalase-3	Glycine max	77-85
11739725-3	2002	The death observed during oxygen deprivation involves a decrease in the mitochondrial membrane potential, followed by the release of cytochrome c and the activation of caspase-9.	Oxygen	26-32	caspase 9	Mus musculus	168-177
20518498-7	2010	Additionally, GLB-6 exhibits rapid two-state autoxidation kinetics in the presence of physiological O(2) levels as well as a low redox potential (-193 +/- 2 mV).	Oxygen	100-104	Globin-like protein 6	Caenorhabditis elegans	14-19
11739725-4	2002	Bcl-X(L) prevented oxygen deprivation-induced cell death by inhibiting the release of cytochrome c and caspase-9 activation.	Oxygen	19-25	BCL2-like 1	Mus musculus	0-8
11739725-4	2002	Bcl-X(L) prevented oxygen deprivation-induced cell death by inhibiting the release of cytochrome c and caspase-9 activation.	Oxygen	19-25	caspase 9	Mus musculus	103-112
10592302-1	1999	We previously reported that microinjection of calcitonin gene-related peptide (CGRP; 1.6-8.0 pmol, 0.2-1.0 microliter) into the ventromedial hypothalamus (VMH) increased oxygen consumption (VO(2)), heart rate (HR), colonic temperature (T(co)), and temperature of interscapular brown adipose tissue (T(IBAT)).	Oxygen	170-176	calcitonin-related polypeptide alpha	Rattus norvegicus	46-77
10592302-1	1999	We previously reported that microinjection of calcitonin gene-related peptide (CGRP; 1.6-8.0 pmol, 0.2-1.0 microliter) into the ventromedial hypothalamus (VMH) increased oxygen consumption (VO(2)), heart rate (HR), colonic temperature (T(co)), and temperature of interscapular brown adipose tissue (T(IBAT)).	Oxygen	170-176	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
11868388-5	2002	One possible idea is that they are members of the defense system against active oxygen, which will be described by Drs.	Oxygen	80-86	sushi repeat containing protein X-linked	Homo sapiens	115-118
20518498-9	2010	Taken together, the biochemical properties of GLB-6 suggest that this neural protein would most likely serve as a physiological sensor for O(2) in C. elegans via redox signaling and/or electron transfer.	Oxygen	139-143	Globin-like protein 6	Caenorhabditis elegans	46-51
12044446-0	2002	BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures.	Oxygen	69-75	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	0-10
10610798-1	1999	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin and non-heme iron-dependent enzyme that hydroxylates L-Phe to l-Tyr using molecular oxygen as additional substrate.	Oxygen	141-147	phenylalanine hydroxylase	Homo sapiens	0-25
10610798-1	1999	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin and non-heme iron-dependent enzyme that hydroxylates L-Phe to l-Tyr using molecular oxygen as additional substrate.	Oxygen	141-147	phenylalanine hydroxylase	Homo sapiens	27-30
10590029-4	1999	Exposure to 100% oxygen for 72 h resulted in an increase of 55% in plasma GPx activity and an increase of 50% in the amount of E-GPx protein in the plasma.	Oxygen	17-23	peroxiredoxin 6 pseudogene 2	Mus musculus	74-77
20442408-1	2010	Endoplasmic reticulum oxidation 1 (ERO1) is a conserved eukaryotic flavin adenine nucleotide-containing enzyme that promotes disulfide bond formation by accepting electrons from reduced protein disulfide isomerase (PDI) and passing them on to molecular oxygen.	Oxygen	253-259	prolyl 4-hydroxylase subunit beta	Homo sapiens	186-213
10585024-11	1999	Platelet-activating factor receptor antagonism with ginkgolide B before the circulatory arrest period can significantly improve recovery of cerebral blood flow and oxygen metabolism and renal blood flow after DHCA.	Oxygen	164-170	platelet activating factor receptor	Homo sapiens	0-35
12088755-7	2002	Under hypoxia, most FGF2-containing cells do not express detectable levels of GFAP, suggesting that chronic low O(2) induces their transformation into more immature glial phenotypes.	Oxygen	112-116	fibroblast growth factor 2	Rattus norvegicus	20-24
20442408-1	2010	Endoplasmic reticulum oxidation 1 (ERO1) is a conserved eukaryotic flavin adenine nucleotide-containing enzyme that promotes disulfide bond formation by accepting electrons from reduced protein disulfide isomerase (PDI) and passing them on to molecular oxygen.	Oxygen	253-259	prolyl 4-hydroxylase subunit beta	Homo sapiens	215-218
11743000-5	2001	A non-bridging phosphate oxygen and the universal G which are essential for Rnt1p binding are strongly exposed.	Oxygen	25-31	ribonuclease III	Saccharomyces cerevisiae S288C	76-81
20143408-1	2010	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions.	Oxygen	104-110	tyrosine hydroxylase	Rattus norvegicus	0-20
11600201-2	2001	Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma.	Oxygen	141-147	interleukin 18	Mus musculus	72-77
11600201-2	2001	Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma.	Oxygen	141-147	interleukin 18	Mus musculus	211-216
10518120-1	1999	In our in vitro model, rasagiline a selective irreversible monoamine oxidase-B (MAO-B) inhibitor, protected nerve growth factor (NGF)-differentiated PC12 cells from cell death under oxygen and glucose deprivation (OGD).	Oxygen	182-188	nerve growth factor	Rattus norvegicus	129-132
10596888-11	1999	The median base line oxygen saturation was 88 and 93%, respectively in Gp I and II pre-operatively and improved to 90.1 and 99.2%, post-operatively.	Oxygen	21-27	glucose-6-phosphate isomerase	Homo sapiens	71-82
20143408-1	2010	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions.	Oxygen	104-110	tyrosine hydroxylase	Rattus norvegicus	22-24
20143408-7	2010	These results indicate that, under hypoxic conditions, TH (a key factor in systemic adaptation to reduced oxygen availability) is not regulated by HIF-1, the primary modulator of the response to hypoxia, but by the adenosine A(2)A receptor-mediated signalling pathway.	Oxygen	106-112	tyrosine hydroxylase	Rattus norvegicus	55-57
11726640-13	2001	CONCLUSIONS: Angiostatin inhibits oxygen-induced intravitreal pathologic retinal angiogenesis without affecting the development of physiological retinal vascularization, development, and growth of newborn mice.	Oxygen	34-40	plasminogen	Mus musculus	13-24
20386489-5	2010	Low-VT ventilation with 50% oxygen significantly increased IL-6 and CXCL-2 expression versus low-VT ventilation alone.	Oxygen	28-34	C-X-C motif chemokine ligand 2	Rattus norvegicus	68-74
10516097-5	1999	Reduction in oxygen levels increased and prolonged the PAPA-NO-induced change in both peak and steady-state glutamate currents in transfected HEK cells.	Oxygen	13-19	pappalysin 1	Homo sapiens	55-59
10516097-6	1999	PAPA-NO also enhanced cell death in primary cultures of rodent cortical neurons deprived of oxygen and glucose.	Oxygen	92-98	pappalysin 1	Homo sapiens	0-4
11689073-5	2001	Using the program Autodock, we show that the iridals dock to the same position on the C1b domain of protein kinase C delta as do the phorbol esters, with the primary hydroxyl group of the iridal at the C3 position forming two hydrogen bonds with the amide group of Thr12 and with the carbonyl group of Leu 21 and the aldehyde oxygen of the iridal forming a hydrogen bond with the amide group of Gly23.	Oxygen	326-332	protein kinase C delta	Homo sapiens	100-122
20386489-7	2010	In contrast, low VT up-regulated CXCL-2 levels were reduced to nonventilated levels when LPS-treated newborn rats were ventilated with 50% oxygen.	Oxygen	139-145	C-X-C motif chemokine ligand 2	Rattus norvegicus	33-39
11229448-6	1999	Xanthine dehydrogenase from mammalian sources can be converted to an oxidase form that readily donates electrons to molecular oxygen, but does not reduce NAD+.	Oxygen	126-132	xanthine dehydrogenase	Homo sapiens	0-22
20427280-3	2010	Furthermore, evidence suggests that human heme oxygenase-2 (HO2) acts as an oxygen sensor and CO donor that can form a protein complex with the BK channel.	Oxygen	47-53	heme oxygenase 2	Homo sapiens	60-63
10589830-3	1999	To identify genes which are involved in the oxygen-dependent activation of the Gal4-Pos9 hybrid protein we screened for mutants that failed to induce the heterologous test system upon oxidative stress (fap mutants for factors activating Pos9).	Oxygen	44-50	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	79-83
11681966-2	2001	For the NPM case it was found that the CD(2)CH(2)SiMe(3) group, initially bound to oxygen, became the CH(2)CD(2)SiMe(3) group bound to carbon in the end product.	Oxygen	83-89	nucleophosmin 1	Homo sapiens	8-11
20171157-2	2010	The Cytb(558) is the catalytic core of the NADPH-oxidase that generates a superoxide anion from oxygen by using a reducing equivalent provided by NADPH via FAD and two hemes.	Oxygen	96-102	cytochrome b	Saccharomyces cerevisiae S288C	4-8
11706343-1	2001	BACKGROUND: Trans-sodium crocetinate (TSC) has been shown to increase oxygen consumption during hemorrhagic shock.	Oxygen	70-76	solute carrier family 12 member 3	Rattus norvegicus	38-41
10508785-9	1999	CONCLUSIONS: The catalytic triad in caspase-8 comprises Cys360, His317 and the backbone carbonyl oxygen atom of Arg258, which points towards the Nepsilon atom of His317.	Oxygen	97-103	caspase 8	Homo sapiens	36-45
20499979-1	2010	CeO(2)-SnO(2) solid solution has been reported to possess high oxygen storage/release property which possibly originates from local structural distortion.	Oxygen	63-69	strawberry notch homolog 1	Homo sapiens	7-10
11498535-2	2001	Rottlerin, a compound reported to be a PKCdelta-selective inhibitor, rapidly increased the rate of oxygen consumption (QO2) of parotid acinar cells and PC12 cells.	Oxygen	99-105	protein kinase C, delta	Rattus norvegicus	39-47
11500508-9	2001	Cu,Zn-SOD1 in the mitochondria appears important for reactive oxygen physiology and may have critical implications for SOD1 mutations linked to the fatal neurodegenerative disorder, amyotrophic lateral sclerosis.	Oxygen	62-68	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	6-10
11681624-1	2001	We investigated the effects of low density-lipoproteins (LDL) and lipoprotein(a) [Lp(a)] oxidized by O2*-/HO* free radicals generated by gamma radiolysis of water, on the release of tissue Plasminogen Activator (tPA) and of its main inhibitor Plaminogen Activator Inhibitor-1 (PAI-1) by human umbilical vein endothelial cells (HUVEC).	Oxygen	101-103	lipoprotein(a)	Homo sapiens	66-80
11681624-1	2001	We investigated the effects of low density-lipoproteins (LDL) and lipoprotein(a) [Lp(a)] oxidized by O2*-/HO* free radicals generated by gamma radiolysis of water, on the release of tissue Plasminogen Activator (tPA) and of its main inhibitor Plaminogen Activator Inhibitor-1 (PAI-1) by human umbilical vein endothelial cells (HUVEC).	Oxygen	101-103	lipoprotein(a)	Homo sapiens	82-87
11591601-0	2001	Oxygen in costs of COPD treatment.	Oxygen	0-6	COPD	Homo sapiens	19-23
20420442-5	2010	The greatest presence of microbial communities also occurred in the up-gradient influent portion of the PRB compared to its down-gradient effluent section, with the latter possibly due to less favorable conditions (i.e., high pH, low oxygen) for microbial growth.	Oxygen	234-240	RB transcriptional corepressor 1	Homo sapiens	104-107
11549604-5	2001	However, after 2 weeks of exposure to 75% oxygen, outer nuclear layer thickness was significantly reduced in littermate control mice compared to FGF2 transgenic mice (P = 0.0001).	Oxygen	42-48	fibroblast growth factor 2	Mus musculus	145-149
19541844-2	2010	Overexpression of CTGF is associated with mechanical ventilation with high tidal volume and oxygen exposure in newborn lungs.	Oxygen	92-98	cellular communication network factor 2	Homo sapiens	18-22
11604023-4	2001	Data set 2 contains 223 compounds having one or more oxygen atoms, with no nitrogen (log S[mol/L] range is -8.77 to 1.57).	Oxygen	53-59	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	5-10
20080866-2	2010	Our hindlimb perfusion model allows the determination of intracellular myoglobin (Mb) saturation ( ) and intracellular oxygen tension of myoglobin ( ) in contracting muscle using near infrared spectroscopy (NIRS).	Oxygen	119-125	myoglobin	Rattus norvegicus	137-146
11692162-12	2001	The phenotypic features of complex II gene mutations suggest that whereas the catalytic subunit SDHA mutations may compromise the Krebs cycle, those in other structural subunits may affect oxygen sensing and signaling.	Oxygen	189-195	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	96-100
20080866-9	2010	Moreover, the rate of release of O(2) from Mb at the onset of contraction increased with muscle oxygen consumption.	Oxygen	33-37	myoglobin	Rattus norvegicus	43-45
11535790-8	2001	ppaZ is expressed only when oxygen becomes limiting.	Oxygen	28-34	pseudoazurin	Rhodobacter sphaeroides 2.4.1	0-4
20080866-9	2010	Moreover, the rate of release of O(2) from Mb at the onset of contraction increased with muscle oxygen consumption.	Oxygen	96-102	myoglobin	Rattus norvegicus	43-45
20233924-5	2010	The anaerobic L-tartrate regulator TtdR or the oxygen sensors ArcB-ArcA and FNR did not have a major effect on dmlA expression.	Oxygen	47-53	arginine deiminase	Escherichia coli	67-71
11778652-9	2001	In villous explant cultures, a reduction in oxygen tension significantly raised the levels of Ang-2 mRNA, and this was dependent on transcription.	Oxygen	44-50	angiopoietin 2	Homo sapiens	94-99
11778652-14	2001	CONCLUSIONS: These data show that the relative levels of Ang-1 and Ang-2 mRNA are regulated by local oxygen tension by different mechanisms and that this may be important during normal human placentation.	Oxygen	101-107	angiopoietin 1	Homo sapiens	57-62
20519072-11	2010	CONCLUSION: CGRP could promote proliferation of AECII when exposed to high oxygen tension.	Oxygen	75-81	calcitonin-related polypeptide alpha	Rattus norvegicus	12-16
11778652-14	2001	CONCLUSIONS: These data show that the relative levels of Ang-1 and Ang-2 mRNA are regulated by local oxygen tension by different mechanisms and that this may be important during normal human placentation.	Oxygen	101-107	angiopoietin 2	Homo sapiens	67-72
20023214-2	2010	Herein we show attenuation of intraocular angiogenesis in alphaB-crystallin knockout (alphaB-crystallin(-/-)) mice in 2 models of intraocular disease: oxygen-induced retinopathy and laser-induced choroidal neovascularization.	Oxygen	151-157	crystallin, alpha B	Mus musculus	58-75
11525742-3	2001	Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water.	Oxygen	212-218	Superoxide dismutase 1	Drosophila melanogaster	0-3
11525742-3	2001	Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water.	Oxygen	212-218	Superoxide dismutase 1	Drosophila melanogaster	88-91
20156434-1	2010	Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1alpha and -2alpha).	Oxygen	9-15	egl-9 family hypoxia inducible factor 2	Homo sapiens	70-76
11549036-1	2001	Two new yeast strains (SPT1 and SPT2) were isolated and immobilized on glassy carbon electrodes to form microbial biosensors for estimation of biochemical oxygen demand (BOD).	Oxygen	155-161	Spt2p	Saccharomyces cerevisiae S288C	32-36
20089120-4	2010	Here, we report that expression of Ndi1 in fly mitochondria leads to an increase in NADH-ubiquinone oxidoreductase activity, oxygen consumption, and ATP levels.	Oxygen	125-131	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	35-39
11430994-1	2001	The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups.	Oxygen	23-29	complement C6	Homo sapiens	44-47
19650690-6	2010	However, the mechanisms of iron homeostasis also are regulated by oxygen availability, with alterations in both hepcidin and IRP activity.	Oxygen	66-72	Wnt family member 2	Homo sapiens	125-128
11463309-1	2001	[reaction: see text] 5-exo-(Hydroxyethylene)-2-oxa-1-silacyclopentanes are found to undergo a novel DMAP-catalyzed skeletal rearrangement through silicon-oxygen exchange during acetylation to yield the corresponding 5-(2-acetoxyalkyl)-2-oxa-1-silacyclopent-4-enes exclusively.	Oxygen	154-160	OXA1L mitochondrial inner membrane protein	Homo sapiens	47-52
11463309-1	2001	[reaction: see text] 5-exo-(Hydroxyethylene)-2-oxa-1-silacyclopentanes are found to undergo a novel DMAP-catalyzed skeletal rearrangement through silicon-oxygen exchange during acetylation to yield the corresponding 5-(2-acetoxyalkyl)-2-oxa-1-silacyclopent-4-enes exclusively.	Oxygen	154-160	OXA1L mitochondrial inner membrane protein	Homo sapiens	237-242
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	glycogen synthase kinase 3 beta	Homo sapiens	120-150
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	225-231	glycogen synthase kinase 3 beta	Homo sapiens	152-161
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	glycogen synthase kinase 3 beta	Homo sapiens	120-150
11408933-3	2001	Of approximately 1200 genes in the array, those associated with integrin-linked kinase (ILK), fibronectin precursor and glycogen synthase kinase-3beta (GSK-3beta) were markedly stimulated after exposure of Hep3B cells to low oxygen (1%) for 6 h. Epo, HIF-1, and von Hippel-Lindau cDNAs were measured in parallel as markers of low oxygen responses in Hep3B cells.	Oxygen	330-336	glycogen synthase kinase 3 beta	Homo sapiens	152-161
11406565-5	2001	We have shown previously that in vitro activation of Met by HGF/SF increases oxygen consumption.	Oxygen	77-83	hepatocyte growth factor	Homo sapiens	60-66
19650690-9	2010	In addition, HIF-2alpha translation is controlled by IRP activity, providing another level of interdependence between iron and oxygen homeostasis.	Oxygen	127-133	Wnt family member 2	Homo sapiens	53-56
20056464-0	2010	EPR characterization of ascorbyl and sulfur dioxide anion radicals trapped during the reaction of bovine Cytochrome c Oxidase with molecular oxygen.	Oxygen	141-147	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	105-125
11351269-14	2001	It has been postulated that iron-induced oxygen radical affects the oxidative phosphorylation in frataxin deficiency states favouring the disease pathology.	Oxygen	41-47	frataxin	Homo sapiens	97-105
20056464-1	2010	The reaction intermediates of reduced bovine Cytochrome c Oxidase (CcO) were trapped following its reaction with oxygen at 50 micros-6 ms by innovative freeze-quenching methods and studied by EPR.	Oxygen	113-119	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	45-65
20056464-1	2010	The reaction intermediates of reduced bovine Cytochrome c Oxidase (CcO) were trapped following its reaction with oxygen at 50 micros-6 ms by innovative freeze-quenching methods and studied by EPR.	Oxygen	113-119	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	67-70
11393516-2	2001	Action of the cytochrome P450 enzyme BX4 from maize on 3-hydroxyindolin-2-one under an 18O2 atmosphere induced production of 2-hydroxy-1,4-benzoxazin-3-one in which the ring oxygen--but not the 2-hydroxy group of HBOA--is labelled.	Oxygen	174-180	3-hydroxyindolin-2-one monooxygenase	Zea mays	37-40
20113439-9	2010	We found that the regulation of HRE1 and HRE2 by low oxygen relies on different mechanisms, since HRE1 requires protein synthesis to be induced while HRE2 does not.	Oxygen	53-59	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	41-45
11278694-5	2001	Similar to many other von Hippel-Lindau tumor-suppressor protein (pVHL) targets, the expression of STRA13 on the mRNA level was hypoxia-sensitive, indicating oxygen-dependent regulation of the gene, presumably through the pVHL/hypoxia-inducible factor 1 (HIF-1) pathway.	Oxygen	158-164	von Hippel-Lindau tumor suppressor	Homo sapiens	66-70
11278694-5	2001	Similar to many other von Hippel-Lindau tumor-suppressor protein (pVHL) targets, the expression of STRA13 on the mRNA level was hypoxia-sensitive, indicating oxygen-dependent regulation of the gene, presumably through the pVHL/hypoxia-inducible factor 1 (HIF-1) pathway.	Oxygen	158-164	basic helix-loop-helix family member e40	Homo sapiens	99-105
20113439-9	2010	We found that the regulation of HRE1 and HRE2 by low oxygen relies on different mechanisms, since HRE1 requires protein synthesis to be induced while HRE2 does not.	Oxygen	53-59	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	150-154
20113439-11	2010	We propose that HRE1 and HRE2 play a partially redundant role in low oxygen signalling in Arabidopsis thaliana, thus improving the tolerance of the plant to the stress by enhancing anaerobic gene expression and ethanolic fermentation.	Oxygen	69-75	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	25-29
20170081-9	2010	Extrapolation of these results to reaction coordinate motion for HGPRT suggests that bond formation between C1" of the nucleotide ribose and the oxygen of PP(i) is accomplished by migration of the ribocation toward immobilized pyrophosphate.	Oxygen	145-151	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	65-70
12587203-2	2001	The results showed the PBS could reduce effectively the chemical dissolved oxygen, NH(4+)-N, vulcanization and organic matter of water bottom, as well as improve the dissolved oxygen.	Oxygen	75-81	cholinergic receptor muscarinic 3	Homo sapiens	23-26
12587203-2	2001	The results showed the PBS could reduce effectively the chemical dissolved oxygen, NH(4+)-N, vulcanization and organic matter of water bottom, as well as improve the dissolved oxygen.	Oxygen	176-182	cholinergic receptor muscarinic 3	Homo sapiens	23-26
20118244-9	2010	These data indicate that HO-2 is important in maintaining endothelial viability and may preserve local regulation of vascular tone, thrombosis, and inflammatory responses during reductions in systemic oxygen delivery.	Oxygen	201-207	heme oxygenase 2	Homo sapiens	25-29
11292862-0	2001	HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.	Oxygen	90-92	von Hippel-Lindau tumor suppressor	Homo sapiens	22-25
11292862-2	2001	In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL).	Oxygen	19-25	von Hippel-Lindau tumor suppressor	Homo sapiens	144-148
19969310-12	2010	Lung function was protected by caspase-3 shRNA therapy, inasmuch as levels of partial pressure of oxygen and carbon dioxide were significantly increased and reduced, respectively.	Oxygen	98-104	caspase 3	Rattus norvegicus	31-40
11325640-7	2001	Oxygen binding studies and simulations showed reduced oxygen affinity (P50) in HbH/beta-thal trait, resulting in increased oxygen release (O2R).	Oxygen	0-6	hemoglobin subunit alpha 2	Homo sapiens	79-82
11325640-7	2001	Oxygen binding studies and simulations showed reduced oxygen affinity (P50) in HbH/beta-thal trait, resulting in increased oxygen release (O2R).	Oxygen	54-60	hemoglobin subunit alpha 2	Homo sapiens	79-82
11325640-7	2001	Oxygen binding studies and simulations showed reduced oxygen affinity (P50) in HbH/beta-thal trait, resulting in increased oxygen release (O2R).	Oxygen	123-129	hemoglobin subunit alpha 2	Homo sapiens	79-82
20158955-0	2010	Amelioration of rCBF and PbtO2 following TBI at high altitude by hyperbaric oxygen pre-conditioning.	Oxygen	76-82	CCAAT/enhancer binding protein zeta	Rattus norvegicus	16-20
11260386-2	2001	Since AT1-Rs enhance oxygen radical (O2-) generation, we tested the hypothesis that the exaggerated TGF was due to a diminished blunting by macula densa (MD)-derived nitric oxide (NO) because of excessive AT1-R-dependent generation of O2-.	Oxygen	37-39	angiotensin II receptor, type 1a	Rattus norvegicus	6-9
20008276-4	2010	In addition, the relevance of single nucleotide polymorphisms (SNPs) of EPHX2 (the gene encoding sEH) on tolerance to oxygen and glucose deprivation and reoxygenation and glucose repletion (OGD/RGR) was assessed in male C57BL\6J (WT) or sEH knockout (sEHKO) cardiomyocytes by using transactivator of transcription (TAT)-mediated transduction with sEH mutant proteins.	Oxygen	118-124	epoxide hydrolase 2	Homo sapiens	72-77
20008276-4	2010	In addition, the relevance of single nucleotide polymorphisms (SNPs) of EPHX2 (the gene encoding sEH) on tolerance to oxygen and glucose deprivation and reoxygenation and glucose repletion (OGD/RGR) was assessed in male C57BL\6J (WT) or sEH knockout (sEHKO) cardiomyocytes by using transactivator of transcription (TAT)-mediated transduction with sEH mutant proteins.	Oxygen	118-124	epoxide hydrolase 2	Homo sapiens	97-100
20130662-0	2010	Fat-free mass and gender influences the rapid-phase excess postexercise oxygen consumption.	Oxygen	72-78	FAT atypical cadherin 1	Homo sapiens	0-3
19699328-1	2010	Manganese superoxide dismutase is an important antioxidant defense metalloenzyme that protects cells from damage by the toxic oxygen metabolite, superoxide free radical, formed as an unavoidable by-product of aerobic metabolism.	Oxygen	126-132	superoxide dismutase 2	Homo sapiens	0-30
20053900-0	2010	Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice.	Oxygen	40-46	Norrie disease (pseudoglioma) (human)	Mus musculus	0-6
20053900-10	2010	We conclude that Norrin is a potent factor to induce angiogenesis in microvascular endothelial cells, which has the distinct potential to suppress the damaging effects of oxygen-induced retinopathy in vivo.	Oxygen	171-177	Norrie disease (pseudoglioma) (human)	Mus musculus	17-23
20238004-0	2010	Increased expression of TGF-beta1 and Smad 4 on oxygen-induced retinopathy in neonatal mice.	Oxygen	48-54	transforming growth factor, beta 1	Mus musculus	24-33
20238004-7	2010	In this study, we used the model of oxygen-induced retinopathy in neonatal mice to investigate the expression of TGF-beta1 and Smad 4 mRNA in the retina, to explore their role in the development of retinal neovascularization.	Oxygen	36-42	transforming growth factor, beta 1	Mus musculus	113-122
20396396-0	2010	B3LYP study on reduction mechanisms from O2 to H2O at the catalytic sites of fully reduced and mixed-valence bovine cytochrome c oxidases.	Oxygen	41-43	LOC104968582	Bos taurus	116-128
20396396-1	2010	Reduction mechanisms of oxygen molecule to water molecules in the fully reduced (FR) and mixed-valence (MV) bovine cytochrome c oxidases (CcO) have been systematically examined based on the B3LYP calculations.	Oxygen	24-30	LOC104968582	Bos taurus	115-127
19435709-7	2010	Increasing force was associated with a linear increase of blood-oxygen-level-dependent (BOLD) signal in bilateral primary motor cortex (M1), supplementary motor area (SMA), caudal cingulate, and cerebellum.	Oxygen	64-70	survival of motor neuron 1, telomeric	Homo sapiens	167-170
21609909-5	2010	The prognosis of BPPV, which is measured as the time until the disappearance of positional nystagmus by a physician during the outpatient visit each week, the relation among the level of oxygen metabolites, vascular molecule and the duration until remission were analyzed.	Oxygen	187-193	benign paroxysmal positional vertigo	Homo sapiens	17-21
10522802-5	1999	RESULTS: Addition of PEP 1261 effectively blocked the H2O2 and O2*- release, decreased the levels of MPO levels (p&lt; 0.01) and lysosomal enzymes (p &lt; 0.05) as compared to PMA stimulated human neutrophils.	Oxygen	56-58	prolyl endopeptidase	Homo sapiens	21-24
20010815-6	2010	Cdk2-/- MEFs also senesced upon ectopic Wnt signalling or, without an oncogene, upon oxygen-induced culture shock.	Oxygen	85-91	cyclin dependent kinase 2	Homo sapiens	0-4
10471280-1	1999	HbPresbyterian (beta 108Asn --&gt; Lys, HbP) contains an additional positive charge (per alpha beta dimer) in the middle of the central cavity and exhibits a lower oxygen affinity than wild-type HbA in the presence of chloride.	Oxygen	164-170	heme binding protein 1	Homo sapiens	0-3
19864924-4	2010	Pulmonary vascular endothelial growth factor (VEGF) expression was analyzed as a possible link between oxygen sensing and surfactant production.	Oxygen	103-109	vascular endothelial growth factor A	Gallus gallus	10-44
10487263-1	1999	BACKGROUND: Severe oxygen-dependent chronic obstructive pulmonary disease (COPD) is considered by many to be a contraindication to open abdominal aortic aneurysm (AAA) repair.	Oxygen	19-25	COPD	Homo sapiens	75-79
10487263-3	1999	METHODS: From July 1995 to March 1999, 14 consecutive patients limited by home oxygen-dependent COPD underwent elective open infrarenal AAA repair.	Oxygen	79-85	COPD	Homo sapiens	96-100
19864924-4	2010	Pulmonary vascular endothelial growth factor (VEGF) expression was analyzed as a possible link between oxygen sensing and surfactant production.	Oxygen	103-109	vascular endothelial growth factor A	Gallus gallus	46-50
10487263-8	1999	CONCLUSIONS: Severe home oxygen-dependent COPD is not a contraindication to safe elective open AAA repair.	Oxygen	25-31	COPD	Homo sapiens	42-46
25376105-0	2009	Facile Construction of Pt-Co/CNx Nanotube Electrocatalysts and Their Application to the Oxygen Reduction Reaction.	Oxygen	88-94	calnexin	Homo sapiens	29-32
10400659-3	1999	Northern blot analysis revealed that the A2AR mRNA level was substantially increased after a 3-h exposure to hypoxia (5% O2), which reached a peak at 12 h. Immunoblot analysis showed that the A2AR protein level was also increased during hypoxia.	Oxygen	121-123	adenosine A2a receptor	Rattus norvegicus	41-45
25376105-2	2009	The as-prepared electrocatalysts exhibit good performance for oxygen reduction reaction in acidic medium arising from the high-dispersion and alloying effect of the Pt-Co nanoparticles and the intrinsic catalytic capacity of the CNx nanotubes.	Oxygen	62-68	calnexin	Homo sapiens	229-232
10400659-3	1999	Northern blot analysis revealed that the A2AR mRNA level was substantially increased after a 3-h exposure to hypoxia (5% O2), which reached a peak at 12 h. Immunoblot analysis showed that the A2AR protein level was also increased during hypoxia.	Oxygen	121-123	adenosine A2a receptor	Rattus norvegicus	192-196
19919101-3	2009	Unlike most class A and class C carbapenem complexes, the acyl carbonyl oxygen in the OXA-1-doripenem complex is bound in the oxyanion hole.	Oxygen	72-78	OXA1L mitochondrial inner membrane protein	Homo sapiens	86-91
10411952-0	1999	LOV (light, oxygen, or voltage) domains of the blue-light photoreceptor phototropin (nph1): binding sites for the chromophore flavin mononucleotide.	Oxygen	12-18	phototropin 1	Arabidopsis thaliana	85-89
19807692-0	2009	Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation.	Oxygen	81-87	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	73-77
10412740-4	1999	METHODS: The impact of human LDL and Lp(a) (oxidized with CuSO4) on O2- formation (detected with a chemiluminescence method), apoptosis, and necrosis (determined with the annexin assay) was studied in cultured human umbilical vein endothelial cells (ECs) and in cultured human mesangial cells (MCs).	Oxygen	68-70	lipoprotein(a)	Homo sapiens	37-42
10333551-9	1999	IGF-I infusion decreased fetal blood glucose, oxygen, urea and amino-nitrogen concentrations, and inhibited placental lactate production.	Oxygen	46-52	insulin-like growth factor I	Ovis aries	0-5
19807692-0	2009	Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation.	Oxygen	81-87	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	182-186
19807692-4	2009	In the present study we show that IXR1 mRNA levels are controlled by oxygen availability and increase during hypoxia.	Oxygen	69-75	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	34-38
10513074-8	1999	CONCLUSIONS: An improvement in gastric pHi associated with an increase in oxygen delivery, was observed with dobutamine.	Oxygen	74-80	glucose-6-phosphate isomerase	Homo sapiens	39-42
10334158-13	1999	pHi decreased from 7.33 +/- 0.08 (mean +/- SD) following resuscitation to 7.26 +/- 0.04 at 24 h, 7.20 +/- 0.07 at 36 h (p &lt; 0.05), and 7.24 +/- 0.08 at 48 h. Corresponding statistically significant and clinically relevant changes in systemic hemodynamic, oxygen utilization, and acid-base variables were not observed.	Oxygen	258-264	glucose-6-phosphate isomerase	Homo sapiens	0-3
19807692-13	2009	A model of IXR1 regulation as a relay for sensing different signals related to change in oxygen availability is proposed.	Oxygen	89-95	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	11-15
10206432-9	1999	Twenty-four hours of normoxia and 1.0 mmol/L glucose increased neuronal GLUT1 mRNA less than threefold above basal, but 24 hours of glucose and oxygen deprivation increased GLUT1 over 111-fold above basal.	Oxygen	144-150	solute carrier family 2 member 1	Rattus norvegicus	173-178
19832699-6	2009	In hippocampal neurons, mitochondrial targeting markedly enhanced the capacity of CsA to prevent cell necrosis brought about by oxygen and glucose deprivation, but largely abolished its capacity to inhibit glutamate-induced cell death.	Oxygen	128-134	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	82-85
19747454-0	2009	Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase.	Oxygen	41-47	mitogen activated protein kinase 14	Rattus norvegicus	118-121
10074355-0	1999	Proton and electron transfer during the reduction of molecular oxygen by fully reduced cytochrome c oxidase: a flow-flash investigation using optical multichannel detection.	Oxygen	63-69	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	87-107
10074355-1	1999	Proton and electron transfer events during the reaction of solubilized fully reduced bovine heart cytochrome c oxidase with molecular oxygen were investigated using the flow-flash technique.	Oxygen	134-140	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	98-118
19782044-5	2009	Following hypoxia treatment in a hypoxic chamber with less than 1% of oxygen, Ad-5HRE-bFGF induced a significant and time-dependent expression of bFGF protein and the fluorescent tag, humanized GFP (hrGFP) protein, in infected PC12 cells.	Oxygen	70-76	fibroblast growth factor 2	Rattus norvegicus	86-90
10052939-3	1999	Whereas mutations in ccoN, ccoQ, and ccoP resulted in PS gene expression in the presence of oxygen, only the ccoQ mutation showed both the normal flow of reductant through the cbb3 oxidase and the absence of any alteration in the relative levels of spheroidene and spheroidenone, as is observed for those mutations in the cco operon that result in the loss of terminal oxidase activity.	Oxygen	92-98	CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone	Rhodobacter sphaeroides 2.4.1	27-31
19683078-7	2009	Oxygen transfer studies found that 18O from [carboxyl-18O] phosphopantothenate is incorporated into the AMP or CMP produced during PPCS catalysis, consistent with the formation of a phosphopantothenoyl cytidylate or phosphopantothenoyl adenylate intermediate, supporting similar catalytic mechanisms under both CTP and ATP conditions.	Oxygen	0-6	phosphopantothenoylcysteine synthetase	Homo sapiens	131-135
10222582-1	1999	The yeast SUC2 gene, cloned on a multicopy plasmid pRB58, was used to study the effect of oxygen on the invertase expression of the recombinant Saccharomyces cerevisiae.	Oxygen	90-96	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	10-14
9927708-2	1999	The first step in JA biosynthesis involves lipoxygenase (LOX) introducing molecular oxygen at the C-13 position of linolenic acid.	Oxygen	46-52	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	57-60
19831352-7	2009	Our results demonstrate the key role of the chain length and the procedure (solvent nature and oxygen presence) in controlling the surface structure and chemistry of SAMs dithiols on Au(111).	Oxygen	95-101	methionine adenosyltransferase 1A	Homo sapiens	166-170
19791770-3	2009	The structure of nNOS-NHA-NO, a close mimic to the dioxygen complex, provides a picture of the potential interactions between the heme-bound diatomic ligand, substrate l-NHA, and the surrounding protein and solvent structure environment.	Oxygen	51-59	nitric oxide synthase 1	Homo sapiens	17-21
9922212-0	1999	Brief exposure to 95% oxygen alters surfactant protein D and mRNA in adult rat alveolar and bronchiolar epithelium.	Oxygen	22-28	surfactant protein D	Rattus norvegicus	36-56
9922212-2	1999	Because other surfactant proteins have been shown to be increased after prolonged periods of hyperoxia, we sought to evaluate the early effects of hyperoxia (95% O2) on expression of SP-D in the adult male rat lung.	Oxygen	162-164	surfactant protein D	Rattus norvegicus	183-187
9922212-4	1999	Northern blot analysis of total lung RNA revealed marked SP-D mRNA increases at 12 h 95% O2 compared with air-exposed controls, with decreasing expression to near that of air-exposed animals by 60 h. Semiquantitative in situ RNA hybridization demonstrated parallel results, with increased numbers of labeled alveolar epithelial (AE) and bronchiolar epithelial (BE) cells at 12 h and increased intensity of labeled alveolar cells, compared with air-exposed controls.	Oxygen	89-91	surfactant protein D	Rattus norvegicus	57-61
9922212-6	1999	In contrast, Western blotting showed a decline in total lung SP-D with 95% O2 exposure, beginning at 12 h and continuing at 36 and 60 h, respectively.	Oxygen	75-77	surfactant protein D	Rattus norvegicus	61-65
11300728-5	2001	The cell death-enhancing action of mutant PS1 was associated with increased production of reactive oxygen species and altered calcium regulation, but not with changes of mitochondrial cytochrome c. Our study further emphasizes the pathogenic role of mutant PS1 and may provide the fundamental basis for new efforts to close the gap between studies using neuronal cell lines transfected with mutant PS1, neurons from transgenic animals, and peripheral cells from AD patients.	Oxygen	99-105	presenilin 1	Homo sapiens	42-45
19626680-9	2009	Our results suggest that lower HIV-1 transcription at 3% O(2) compared to 21% O(2) may be mediated by lower activity of CDK9/cyclin T1 and Sp1 at 3% O(2) and that additional host cell factors such as CDK2 and NF-kappaB might be major regulators of HIV-1 transcription at low O(2) concentrations.	Oxygen	57-61	cyclin dependent kinase 2	Homo sapiens	200-204
11133990-2	2001	In response to low oxygen levels, autophosphorylated ArcB phosphorylates ArcA, and the resulting phosphorylated ArcA (ArcA-P) functions as a transcriptional regulator of the genes necessary to maintain anaerobic growth.	Oxygen	19-25	arginine deiminase	Escherichia coli	73-77
19760708-4	2009	The basicity of lattice oxygen atoms is correlated with the adsorption energy: BaO (-3.02 eV) &gt; SrO (-2.85 eV) &gt; CaO (-2.05 eV) &gt; MgO (-1.35 eV).	Oxygen	24-30	stomatin like 3	Homo sapiens	99-102
11133990-2	2001	In response to low oxygen levels, autophosphorylated ArcB phosphorylates ArcA, and the resulting phosphorylated ArcA (ArcA-P) functions as a transcriptional regulator of the genes necessary to maintain anaerobic growth.	Oxygen	19-25	arginine deiminase	Escherichia coli	112-116
11133990-2	2001	In response to low oxygen levels, autophosphorylated ArcB phosphorylates ArcA, and the resulting phosphorylated ArcA (ArcA-P) functions as a transcriptional regulator of the genes necessary to maintain anaerobic growth.	Oxygen	19-25	arginine deiminase	Escherichia coli	118-124
9989587-1	1999	Irreversible conversion of xanthine dehydrogenase (XDH) to its oxygen free radical producing oxidase (XO) form occurs through an uncharacterized proteolytic process, which was studied in human liver.	Oxygen	63-69	xanthine dehydrogenase	Homo sapiens	27-49
9989587-1	1999	Irreversible conversion of xanthine dehydrogenase (XDH) to its oxygen free radical producing oxidase (XO) form occurs through an uncharacterized proteolytic process, which was studied in human liver.	Oxygen	63-69	xanthine dehydrogenase	Homo sapiens	51-54
9891025-1	1999	The stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived PC12 cell line.	Oxygen	122-128	tyrosine hydroxylase	Rattus norvegicus	26-46
9891025-1	1999	The stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived PC12 cell line.	Oxygen	122-128	tyrosine hydroxylase	Rattus norvegicus	48-50
10325805-8	1999	Reduced oxygen dependency at the postconceptional age of 36 weeks (RR 0.50, 95% CI 0.32-0.78) was found, but so was an increase in grades 3 and 4 intraventricular haemorrhage (IVH) (RR 1.31, 95% CI 1.04-1.66).	Oxygen	8-14	ribonucleotide reductase catalytic subunit M1	Homo sapiens	182-186
10440237-7	1999	The recent observations that changes in oxygen tension regulate both IRP1 and IRP2 RNA binding activities will be addressed in light of ROS regulation of the IRPs.	Oxygen	40-46	aconitase 1	Homo sapiens	69-73
11237528-5	2001	The VHL gene product, pVHL, is a component of an E3 ubiquitin ligase that targets the alpha subunits of the HIF (hypoxia-inducible factor) transcription factor for destruction in the presence of oxygen.	Oxygen	195-201	von Hippel-Lindau tumor suppressor	Homo sapiens	22-26
11179510-5	2001	The increase in MnSOD in the presence of Fe(3+)-NTA was greater under the condition of 20% O(2) than under the condition of 1% O(2).	Oxygen	91-95	superoxide dismutase 2	Homo sapiens	16-21
11159441-4	2001	Because the oxygen transport rate in the SLOT domain is a factor of two smaller than that in purple membrane, where bacteriorhodopsin is aggregated, we propose that the SLOT domain in the viral membrane is the cholesterol-rich raft domain stabilized by the trimers of hemagglutinin and/or the tetramers of neuraminidase.	Oxygen	12-18	neuraminidase 1	Homo sapiens	306-319
19761223-10	2009	The Fe/S cluster defect and the Fe-accumulation phenotype, resulting from the depletion of Atm1p in aerobic cells (but not in anaerobic cells), may be secondary effects that are observed only when cells are exposed to oxygen during growth.	Oxygen	218-224	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	91-96
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	46-48	Rho guanine nucleotide exchange factor 12	Homo sapiens	25-30
19657056-0	2009	Identification of subdomains in NADPH oxidase-4 critical for the oxygen-dependent regulation of TASK-1 K+ channels.	Oxygen	65-71	NADPH oxidase 4	Homo sapiens	32-47
11341971-9	2001	However, such marked changes in the transcript levels of HKII and GLUT1 were not observed when AH130 cells were cultured in dishes under a hypoxic condition, indicating that the observed changes were not solely attributable to the difference in oxygen concentration between the ascites and cell culture conditions.	Oxygen	245-251	solute carrier family 2 member 1	Rattus norvegicus	66-71
19657056-2	2009	Previously, it was demonstrated that the cooperative action of TASK-1 and NADPH oxidase-4 (NOX4) mediated the O2-sensitive K+ current response.	Oxygen	110-112	NADPH oxidase 4	Homo sapiens	74-89
19657056-2	2009	Previously, it was demonstrated that the cooperative action of TASK-1 and NADPH oxidase-4 (NOX4) mediated the O2-sensitive K+ current response.	Oxygen	110-112	NADPH oxidase 4	Homo sapiens	91-95
19657056-3	2009	Here we addressed the O2-sensing mechanism of NOX4 in terms of TASK-1 regulation.	Oxygen	22-24	NADPH oxidase 4	Homo sapiens	46-50
11579699-1	1998	The purpose of this study was to verify the difference between carrying a load on the sacrum (LOS) and on the lumbar vertebrae (LOL) in oxygen uptake, muscle activities, heart rate, cadence, and subjective response.	Oxygen	136-142	lysyl oxidase like 1	Homo sapiens	128-131
11579699-5	1998	The following was significantly higher in LOL than in LOS: oxygen uptake; IEMG of the tibial anterior, soleus, and medial head of gastrocnemius; cadence; and rated perceived exertion.	Oxygen	59-65	lysyl oxidase like 1	Homo sapiens	42-45
11024059-5	2001	Localization studies in HIF-1alpha-null embryonic cells suggest that exon 2-encoded beta-domain mediates transcription-dependent nuclear/cytoplasmic shuttling of VHL independently of assembly with HIF-1alpha and oxygen concentration.	Oxygen	212-218	von Hippel-Lindau tumor suppressor	Homo sapiens	162-165
19657056-4	2009	In TASK-1 and NOX4-coexpressing human embryonic kidney 293 cells, hypoxia (5% O2) decreased the amplitude of TASK-1 current (hypoxia-DeltaI(TASK-1)).	Oxygen	78-80	NADPH oxidase 4	Homo sapiens	14-18
19576887-4	2009	Here we report that pretreatment of cultured cortical neurons with TK reduced cell death induced by either acidosis or oxygen and glucose deprivation-acidosis/reoxygenation (OGD-A/R).	Oxygen	119-125	kallikrein 1	Homo sapiens	67-69
21290715-5	2001	In Escherichia coli, for example, they involve the oxygen-sensing activities of Fnr and the ArcA/ArcB system (51).	Oxygen	51-57	arginine deiminase	Escherichia coli	92-96
11286349-5	1998	MEASUREMENTS AND RESULTS: The chronotropic 25 dose (CD25), an in vivo measure of beta-adrenergic receptor sensitivity derived from the heart rate response to a graded infusion of isoproterenol, was determined while subjects breathed either a normoxic (21% O2, 79% N2) or a hypoxic (15% O2, 85% N2) gas mixture.	Oxygen	256-258	interleukin 2 receptor subunit alpha	Homo sapiens	52-56
11286349-5	1998	MEASUREMENTS AND RESULTS: The chronotropic 25 dose (CD25), an in vivo measure of beta-adrenergic receptor sensitivity derived from the heart rate response to a graded infusion of isoproterenol, was determined while subjects breathed either a normoxic (21% O2, 79% N2) or a hypoxic (15% O2, 85% N2) gas mixture.	Oxygen	286-288	interleukin 2 receptor subunit alpha	Homo sapiens	52-56
19670369-3	2009	Lowering of O(2) from 21 to 5% induced upregulation of cofilin-1, cyclophilin A, tubulin and tubulin fragments, a fragment of glucose-regulated protein 78 (Grp78) and calmodulin.	Oxygen	12-16	cofilin 1	Homo sapiens	55-64
19670369-6	2009	Exposure to 1% O(2) caused increases in cofilin-1, cyclophilin A, and caspase 12 as well as a decrease of beta-actin, but it did not alter the expression of calmodulin, tubulin, Grp78, and Grp94.	Oxygen	15-19	cofilin 1	Homo sapiens	40-49
9761743-0	1998	Involvement of a local fenton reaction in the reciprocal modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes.	Oxygen	71-73	glucokinase	Rattus norvegicus	201-212
11701096-0	2001	Di-, tri- and tetra-5"-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.	Oxygen	128-134	fragile histidine triad diadenosine triphosphatase	Homo sapiens	84-88
19670369-8	2009	The present investigations reveal that lowering O(2), probably in part through hypoxia-inducible factor, alter the expression of a series of proteins mainly involved in cytoskeletal changes (e.g. cofilin-1, tubulin, and beta-actin) and in ER stress/apoptosis (e.g. Grp78/94, caspase 12, and cyclophilin A).	Oxygen	48-52	cofilin 1	Homo sapiens	196-205
11701096-7	2001	CONCLUSIONS: The best Fhit inhibitors obtained to date separate two or more 5"-O-phosphoromonothioadenosyl moieties with as many bond lengths as in AppppA, maintain oxygen at the location of the alpha-beta bridging oxygen, and replace carbon for the beta phosphorus.	Oxygen	165-171	fragile histidine triad diadenosine triphosphatase	Homo sapiens	22-26
11701096-7	2001	CONCLUSIONS: The best Fhit inhibitors obtained to date separate two or more 5"-O-phosphoromonothioadenosyl moieties with as many bond lengths as in AppppA, maintain oxygen at the location of the alpha-beta bridging oxygen, and replace carbon for the beta phosphorus.	Oxygen	215-221	fragile histidine triad diadenosine triphosphatase	Homo sapiens	22-26
11172717-1	2001	TUP1 is recruited to and represses genes that regulate mating, glucose and oxygen use, stress response, and DNA damage.	Oxygen	75-81	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	0-4
11727931-9	2001	The majority of these show hypoxia-inducible responses, supporting the central involvement of pVHL in gene regulation by oxygen.	Oxygen	121-127	von Hippel-Lindau tumor suppressor	Homo sapiens	94-98
11727931-13	2001	Equally regulation of the HIF-1alpha/pVHL interaction in normal cells should provide insights into the physiological mechanisms operating in cellular oxygen sensing.	Oxygen	150-156	von Hippel-Lindau tumor suppressor	Homo sapiens	37-41
9761743-1	1998	H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene.	Oxygen	2-4	glucokinase	Rattus norvegicus	200-211
9761743-1	1998	H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene.	Oxygen	2-4	glucokinase	Rattus norvegicus	213-215
9761743-7	1998	GK mRNA was induced by insulin with reciprocal modulation by O2.	Oxygen	61-63	glucokinase	Rattus norvegicus	0-2
9761743-8	1998	DSF and DMTU reduced the induction of PCK mRNA to about half-maximal and increased the induction of GK mRNA to maximal under both O2 tensions.	Oxygen	130-132	glucokinase	Rattus norvegicus	100-102
9761743-13	1998	Thus a local Fenton reaction is involved in the O2 signalling, which modulated the glucagon- and insulin-dependent PCK gene and GK gene activation.	Oxygen	48-50	glucokinase	Rattus norvegicus	128-130
9761750-6	1998	Adult mice were exposed to 100% O2 for up to 96 h. We analyzed PECAM-1 expression by RNA blot hybridization, in situ hybridization, and immunohistochemistry.	Oxygen	32-34	platelet/endothelial cell adhesion molecule 1	Mus musculus	63-70
19772569-4	2009	In rat, O2 toxicity caused reduced levels of Lgl1, which normalized during recovery.	Oxygen	8-10	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	45-49
9760325-5	1998	Treadmill-determined maximal oxygen consumption was positively related (r = 0.40, P &lt; 0.05) to CS in the gastrocnemius but not in the VL.	Oxygen	29-35	citrate synthase	Homo sapiens	98-100
9789333-1	1998	The hydrogen (H2) clearance method was adapted for the measurement of regional cerebral blood flow (rCBF) in anesthetized rats and mice during hyperbaric oxygen (HBO2) exposure.	Oxygen	154-160	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
9750275-2	1998	When growing in shake flasks, under various methane and oxygen tensions, culture MM1 revealed the capability of a stable association consisting of one obligate methanotroph with type II intracytoplasmic membranes as the dominant strain, and four or five heterotrophs of different morphological, physiological and metabolic characteristics.	Oxygen	56-62	prefoldin subunit 5	Homo sapiens	81-84
9727060-9	1998	Furthermore, homozygous null uPA (uPA -/-) and tPA (tPA -/-) mice subjected to oxygen deprivation showed increased fibrin deposition compared with wild-type controls.	Oxygen	79-85	plasminogen activator, tissue	Mus musculus	34-60
9685416-7	1998	Moreover, pervanadate activation of ErbB-4 cleavage, but not that of 12-O-tetradecanoylphorbol-13-acetate , is blocked by the oxygen radical scavenger pyrrolidine dithiocarbomate.	Oxygen	126-132	erb-b2 receptor tyrosine kinase 4	Homo sapiens	36-42
9694661-4	1998	It is suggested that C/H/O/S ratios are important factors in controlling the degree of prebiotic organic synthesis and, hence, the emergence of life, since if oxygen is abundant, CO2 and SO2 would have been dominant species.	Oxygen	159-165	lysosomal trafficking regulator	Homo sapiens	21-28
9611167-0	1998	Evidence for a role for AtMYB2 in the induction of the Arabidopsis alcohol dehydrogenase gene (ADH1) by low oxygen.	Oxygen	108-114	myb domain protein 2	Arabidopsis thaliana	24-30
9611167-0	1998	Evidence for a role for AtMYB2 in the induction of the Arabidopsis alcohol dehydrogenase gene (ADH1) by low oxygen.	Oxygen	108-114	alcohol dehydrogenase 1	Arabidopsis thaliana	95-99
9611167-2	1998	The binding to the GT-motif (5"-TGGTTT-3") is essential for induction of ADH1 by low oxygen, while binding to the second motif, MBS-2, is not essential for induction.	Oxygen	85-91	alcohol dehydrogenase 1	Arabidopsis thaliana	73-77
9611167-7	1998	These results are consistent with AtMYB2 being a key regulatory factor in the induction of the ADH1 promoter by low oxygen.	Oxygen	116-122	myb domain protein 2	Arabidopsis thaliana	34-40
9611167-7	1998	These results are consistent with AtMYB2 being a key regulatory factor in the induction of the ADH1 promoter by low oxygen.	Oxygen	116-122	alcohol dehydrogenase 1	Arabidopsis thaliana	95-99
9620079-4	1998	Catalase activity was measured by H2O2 decomposition, usually at 100 microM and 10 mM H2O2, and in some cases by O2 generation.	Oxygen	36-38	catalase	Bos taurus	0-8
9620079-14	1998	Catalase may be the macromolecular component responsible for aqueous H2O2 decay, as evidenced by H2O2 degradation, inhibition by boiling or 3-aminotriazole, and the approximate correspondence between oxygen generation and H2O2 degradation.	Oxygen	200-206	catalase	Bos taurus	0-8
9574558-10	1998	These findings suggest that TNF-alpha down-regulates CXCR2 expression on PMNs and modulates IL-8-induced biologic responses, leading to the intravascular retention of PMNs with an enhanced production of reactive oxygen metabolites.	Oxygen	212-218	C-X-C motif chemokine receptor 2	Homo sapiens	53-58
9545294-2	1998	Purified XylE is oxygen-sensitive and unstable in vitro, particularly in the presence of substituted catechol substrates, but it is stabilized in vivo by another protein, XylT, encoded by the xylT gene located just upstream of xylE.	Oxygen	17-23	catechol 2,3-dioxygenase	Pseudomonas putida	9-13
9535869-2	1998	Nitric oxide synthase (NOS) catalyzes the NADPH- and O2-dependent conversion of L-arginine to nitric oxide (NO) and citrulline; three isoforms, the neuronal (nNOS), endothelial, and inducible, have been identified.	Oxygen	53-55	nitric oxide synthase 1	Homo sapiens	0-21
9535869-7	1998	However, in the presence of NADPH and O2, L-VNIO irreversibly inactivates nNOS (kinact = 0.078 min-1; KI = 90 nM); inactivation is Ca2+/calmodulin-dependent.	Oxygen	38-40	nitric oxide synthase 1	Homo sapiens	74-78
9575883-4	1998	O2 exposure for 6 or 14 days reduced IGFBP-3 and -6 and increased IGFBP-4 mRNA abundance.	Oxygen	0-2	insulin-like growth factor binding protein 4	Rattus norvegicus	66-73
9510525-8	1998	The oxygen affinity in the active ADP-stimulated state is higher in mitochondria from heart than in those from liver, in direct relationship to the higher excess capacity of COX in heart.	Oxygen	4-10	cytochrome c oxidase subunit 8A	Homo sapiens	174-177
9510525-9	1998	This yields, in turn, a lower turnover rate of COX even at maximum flux through the respiratory chain, which is necessary to prevent a large decrease in oxygen affinity in the active state.	Oxygen	153-159	cytochrome c oxidase subunit 8A	Homo sapiens	47-50
9510525-10	1998	Up-regulation of oxygen affinity provides a functional explanation of the excess capacity of COX.	Oxygen	17-23	cytochrome c oxidase subunit 8A	Homo sapiens	93-96
11209853-2	2001	Extra-framework aluminium species, formed upon expulsion of aluminium from the framework, are detected by DRS because they are involved in aluminium-oxygen charge transfer transitions.	Oxygen	149-155	sushi repeat containing protein X-linked	Homo sapiens	106-109
10969075-9	2000	These results indicate that SP-A and SP-D, which are ubiquitous among air breathing organisms, could contribute to the protection of the lung from oxidative stresses due to atmospheric or supplemental oxygen, air pollutants, and lung inflammation.	Oxygen	201-207	surfactant protein A1	Homo sapiens	28-32
11139368-3	2000	availability in brain tissue during hyperbaric oxygen (HBO(2)) exposure contribute to decreases in regional cerebral blood flow (rCBF).	Oxygen	47-53	CCAAT/enhancer binding protein zeta	Rattus norvegicus	129-133
11139368-9	2000	After 30 min of O(2) exposure at 5 ATA, rCBF had decreased in the substantia nigra, caudate putamen, hippocampus, and parietal cortex by 23 to 37%.	Oxygen	16-20	CCAAT/enhancer binding protein zeta	Rattus norvegicus	40-44
11077085-9	2000	Based on molecular modeling with the PM3 method, along with the present inhibition and inactivation results, it is thought that both the steric effects of the 6-substituents as well as the electronic effects of the C-6 oxygen functions play a critical role in the binding of inhibitors to the active site of aromatase.	Oxygen	219-225	complement C6	Homo sapiens	215-218
11000584-7	2000	In addition, LAK cell-activated bid may have increased the intracellular reactive oxygen intermediates (ROI) level and induced a decrease of mitochondrial membrane potential.	Oxygen	82-88	ADP ribosylation factor like GTPase 4C	Homo sapiens	13-16
11007895-5	2000	Furthermore, addition of BMP2 plus forskolin in decreased oxygen cultures elicited differentiation of thousands of cells expressing tyrosine hydroxylase, dopamine-beta-hydroxylase, and the SA lineage marker SA-1 in nearly all colonies.	Oxygen	58-64	bone morphogenetic protein 2	Homo sapiens	25-29
10950858-0	2000	Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction.	Oxygen	17-23	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	76-80
10980033-14	2000	Following hypoxia (6% O(2) for 5 min), PKCdelta-like immunoreactivity translocated to the plasma membrane in 87 +/- 3% of the cells, indicating PKC activation.	Oxygen	22-26	protein kinase C gamma type	Oryctolagus cuniculus	39-47
10972830-4	2000	We found that Hap1p activity, known to be oxygen dependent, is effected by DNA-protein interaction with two binding sites present in the CYB2 promoter.	Oxygen	42-48	L-lactate dehydrogenase (cytochrome)	Saccharomyces cerevisiae S288C	137-141
10874132-10	2000	nNOS-activated MC resulted in the consumption of oxygen in air.	Oxygen	49-55	nitric oxide synthase 1	Homo sapiens	0-4
19694477-3	2009	On the basis of G3MP2//B3LYP/cc-pVTZ+d and highly accurate W1U calculations, the reaction of HOO with 3SO species has also been explored, and the following dominant consecutive reactions may describe the fast oxygen transfer HO2 + 3SO --&gt; 4HOO x SO --&gt; 2HOOSO --&gt; OH + SO2.	Oxygen	209-215	heme oxygenase 2	Homo sapiens	225-228
10906152-14	2000	These data provide evidence that AngII- mediated oxygen stress leads to the phosphorylation of p44/42 MAP kinase in proximal tubular cells.	Oxygen	49-55	interferon induced protein 44	Homo sapiens	95-98
19561522-1	2009	PURPOSE: Plasma B-type natriuretic peptide (BNP) levels obtained at rest have been previously shown to be correlated with the global functional capacity measures of peak oxygen uptake (V(O(2peak))) and the minute ventilation/carbon dioxide (VE/V(O(2))) slope.	Oxygen	170-176	natriuretic peptide B	Homo sapiens	44-47
10919671-1	2000	Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix.	Oxygen	161-167	superoxide dismutase 2	Homo sapiens	0-41
10919671-1	2000	Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix.	Oxygen	161-167	superoxide dismutase 2	Homo sapiens	43-48
19280118-6	2009	SDF-1 secretion was inversely related to oxygen levels, with more severe degrees of hypoxia inducing greater levels of SDF-1 secretion.	Oxygen	41-47	chemokine (C-X-C motif) ligand 12	Mus musculus	0-5
10869423-7	2000	Our data suggest that Renox, as a renal source of reactive oxygen species, is a likely candidate for the oxygen sensor function regulating oxygen-dependent gene expression and may also have a role in the development of inflammatory processes in the kidney.	Oxygen	59-65	NADPH oxidase 4	Homo sapiens	22-27
10869423-7	2000	Our data suggest that Renox, as a renal source of reactive oxygen species, is a likely candidate for the oxygen sensor function regulating oxygen-dependent gene expression and may also have a role in the development of inflammatory processes in the kidney.	Oxygen	105-111	NADPH oxidase 4	Homo sapiens	22-27
10862587-8	2000	The lower slope of oxygen uptake was correlated with a subnormal value for ventilatory anaerobic threshold, which averaged 78.0 (13.3)% of normal in TGA and 85.1 (10.6)% in TF.	Oxygen	19-25	T-box transcription factor 1	Homo sapiens	149-152
10862587-9	2000	This was associated with a steeper slope (p = 0.001) of carbon dioxide output versus oxygen uptake above the ventilatory anaerobic threshold in TGA (1.26 (0.20)) and TF (1.20 (0.	Oxygen	85-91	T-box transcription factor 1	Homo sapiens	144-147
10828001-1	2000	The purpose of the present study was to visualize myoglobin-facilitated oxygen delivery to mitochondria at a critical mitochondrial oxygen supply in single isolated cardiomyocytes of rats.	Oxygen	72-78	myoglobin	Rattus norvegicus	50-59
10828001-1	2000	The purpose of the present study was to visualize myoglobin-facilitated oxygen delivery to mitochondria at a critical mitochondrial oxygen supply in single isolated cardiomyocytes of rats.	Oxygen	132-138	myoglobin	Rattus norvegicus	50-59
10828001-7	2000	Thus we conclude that myoglobin significantly facilitates intracellular oxygen transport at a critical level of mitochondrial oxygen supply in single cardiomyocytes.	Oxygen	72-78	myoglobin	Rattus norvegicus	22-31
10828001-7	2000	Thus we conclude that myoglobin significantly facilitates intracellular oxygen transport at a critical level of mitochondrial oxygen supply in single cardiomyocytes.	Oxygen	126-132	myoglobin	Rattus norvegicus	22-31
10929046-6	2000	We showed that the exchange of human zeta-globin for human alpha-globin chains increased haemoglobin O2 affinity, both in the presence and in the absence of 2, 3-bisphosphoglycerate (2,3-BPG), and reduced the pH-dependent shift in its oxygen equilibrium curve (Bohr effect).	Oxygen	235-241	hemoglobin subunit alpha 2	Homo sapiens	59-71
10825144-0	2000	Endogenous interleukin-18 modulates immune escape of murine melanoma cells by regulating the expression of Fas ligand and reactive oxygen intermediates.	Oxygen	131-137	interleukin 18	Mus musculus	11-25
10825144-7	2000	In addition, the same treatments decreased intracellular reactive oxygen intermediate levels in B16F10 melanoma cells, indicating that IL-18 regulates reactive oxygen intermediate production, which is involved in Fas ligand expression.	Oxygen	66-72	interleukin 18	Mus musculus	135-140
10779683-1	2000	The well known NADP-specific isocitrate dehydrogenase (IDH) obtained from pig heart was found to oxidize NADH with accompanying consumption of oxygen (NADH:O(2)=1:1) in presence of polyvanadate.	Oxygen	143-149	isocitrate dehydrogenase [NADP] cytoplasmic	Sus scrofa	55-58
10934596-5	2000	It was found that 1,1-azabicyclohexanecarbonitrile-2-methylpropionamidine dihydrochloride (an azoinitiator capable of spontaneous decomposition with the formation of peroxide radicals in an oxygen containing-medium) introduced into an MLP suspension produces the same effect as Fe3+ and Cu2+ ions.	Oxygen	190-196	cysteine and glycine rich protein 3	Homo sapiens	235-238
10751188-3	2000	Nine weeks of leg cycle endurance training [75% peak oxygen consumption (VO(2 peak))] increased muscle citrate synthase activity (+75%, P &lt; 0.05) and percentage of type I myosin heavy chain (+50%, P &lt; 0.05); percentage of MU lactate dehydrogenase-5 (M4) isozyme decreased (-12%, P &lt; 0.05).	Oxygen	53-59	citrate synthase	Homo sapiens	103-119
10745077-8	2000	Based on the X-ray structural analysis of caspase-8, a main chain carbonyl oxygen appears to be involved in a catalytic triad with the active site Cys and His residues.	Oxygen	75-81	caspase 8	Homo sapiens	42-51
10712429-0	2000	Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development.	Oxygen	62-68	transforming growth factor beta 3	Homo sapiens	114-121
10712429-9	2000	These data suggest that the oxygen-regulated early events of trophoblast differentiation are in part mediated by TGFbeta(3) through HIF-1 transcription factors.	Oxygen	28-34	transforming growth factor beta 3	Homo sapiens	113-123
10779265-5	2000	A logistic regression model was used to investigate the confounding effect of duration of mechanical ventilation and oxygen therapy, birthweight, Apgar score, and serum inositol concentration on development of ROP.	Oxygen	117-123	opsin 1, long wave sensitive	Homo sapiens	210-213
10684655-1	2000	Activation of photosynthesis (PS) gene expression by the PrrBA two-component activation system in Rhodobacter sphaeroides 2.4.1 results from the interruption of an inhibitory signal originating from the cbb(3) cytochrome c oxidase via its interaction with oxygen, in conjunction with the Rdx redox proteins.	Oxygen	256-262	cytochrome c	Rhodobacter sphaeroides 2.4.1	210-222
10684655-2	2000	The CcoQ protein, encoded by the ccoNOQP operon, which encodes the cbb(3) cytochrome c oxidase, was shown to act as a "transponder" that conveys the signal derived from reductant flow through cbb(3) to oxygen, to the Prr system.	Oxygen	202-208	CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone	Rhodobacter sphaeroides 2.4.1	4-8
10684655-2	2000	The CcoQ protein, encoded by the ccoNOQP operon, which encodes the cbb(3) cytochrome c oxidase, was shown to act as a "transponder" that conveys the signal derived from reductant flow through cbb(3) to oxygen, to the Prr system.	Oxygen	202-208	cytochrome c	Rhodobacter sphaeroides 2.4.1	74-86
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	Oxygen	53-59	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	0-27
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	Oxygen	53-59	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	29-32
10719243-4	2000	We proposed that HBO-induced convulsions result from increased flux through the KYN pathway via oxygen stimulation of IDO.	Oxygen	96-102	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	118-121
10719243-7	2000	Conversely, IDO had almost no detectable activity at or below 100 microM oxygen and maximum activity was not reached until about 1150 microM.	Oxygen	73-79	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	12-15
10719243-10	2000	While the oxygen concentration inside cells of rats breathing air or HBO is not known precisely, it is clear that the rate-limiting, IDO-catalyzed step in the brain KYN pathway (but not liver TDO) can be greatly accelerated in rats breathing HBO.	Oxygen	10-16	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	133-136
10746428-0	2000	Inhibitory effects of angiotensin-converting enzyme (ACE) inhibitors on oxygen radicals produced by bronchoalveolar lavage cells in young and aged guinea pigs.	Oxygen	72-78	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	53-56
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	67-73	alcohol dehydrogenase 1	Zea mays	85-89
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	205-211	alcohol dehydrogenase 1	Zea mays	85-89
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	252-254	alcohol dehydrogenase 1	Zea mays	85-89
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	266-268	alcohol dehydrogenase 1	Zea mays	85-89
10673377-1	2000	The 150-kDa oxygen-regulated protein (ORP150) is a member of glucose-regulated proteins (GRPs), which are induced by stressful conditions such as oxygen or glucose deprivation.	Oxygen	12-18	hypoxia up-regulated 1	Mus musculus	38-44
11272523-5	2000	The ethylene ligand of complexes TpMe2Rh(C2H4)(PR3) is labile, and several peroxo compounds of composition TpMe2Rh(O2)(PR3) have been isolated by their reaction with O2.	Oxygen	166-168	proteinase 3	Homo sapiens	47-50
11272523-5	2000	The ethylene ligand of complexes TpMe2Rh(C2H4)(PR3) is labile, and several peroxo compounds of composition TpMe2Rh(O2)(PR3) have been isolated by their reaction with O2.	Oxygen	166-168	proteinase 3	Homo sapiens	119-122
10633045-4	2000	In each case, the nitrogen at position-1 of the quinazoline accepted a hydrogen bond from a backbone NH (CDK2, Leu-83; p38, Met-109) of the domain connector strand, and aromatic hydrogen atoms at C2 and C8 interacted with backbone carbonyl oxygen atoms of the peptide strand.	Oxygen	240-246	cyclin dependent kinase 2	Homo sapiens	105-109
10643788-1	2000	By using a specific antibody, 5-HT5a receptor-like immunoreactivity was revealed in the chemoreceptive, oxygen sensitive, carotid body (CB) type I cells, and neurons of the petrosal ganglion (PG) and the superior cervical ganglion (SCG) in rat.	Oxygen	104-110	5-hydroxytryptamine receptor 5A	Rattus norvegicus	30-36
10849669-4	2000	Given the similarities between NO and O2, we hypothesized that NO inhibits hypoxia-induced up-regulation of c-fos and TH.	Oxygen	38-40	tyrosine hydroxylase	Rattus norvegicus	118-120
10849669-7	2000	Hypoxia (1% O2 for 6 h) up-regulated c-fos and TH mRNA and increased c-fos promoter activity.	Oxygen	12-14	tyrosine hydroxylase	Rattus norvegicus	47-49
10849670-5	2000	Exposure to moderate hypoxia (5% O2) was found to progressively stimulate phosphorylation and activation of p38 gamma in particular, and also p38 alpha, two isoforms of the p38 family of stress-activated protein kinases.	Oxygen	33-35	mitogen activated protein kinase 14	Rattus norvegicus	108-111
10849670-5	2000	Exposure to moderate hypoxia (5% O2) was found to progressively stimulate phosphorylation and activation of p38 gamma in particular, and also p38 alpha, two isoforms of the p38 family of stress-activated protein kinases.	Oxygen	33-35	mitogen activated protein kinase 14	Rattus norvegicus	142-151
10849670-5	2000	Exposure to moderate hypoxia (5% O2) was found to progressively stimulate phosphorylation and activation of p38 gamma in particular, and also p38 alpha, two isoforms of the p38 family of stress-activated protein kinases.	Oxygen	33-35	mitogen activated protein kinase 14	Rattus norvegicus	142-145
10849697-10	2000	In NOS-1 mutant mice, the ventilatory response to hypoxia (12% O2) were significantly augmented, compared to wild-type (WT) mice.	Oxygen	63-65	nitric oxide synthase 1, neuronal	Mus musculus	3-8
10605937-5	2000	Signals that target the iso-IRE/iso-IRP interactions in mRNA include environmental iron, O2, nitric oxide, H2O2, ascorbate, growth factors, and protein kinase C-dependent IRP phosphorylation.	Oxygen	89-91	Wnt family member 2	Homo sapiens	36-39
10605937-7	2000	With the iso-IRE/iso-IRP system, nature has evolved coordinated combinatorial control of iron and oxygen metabolism that may exemplify control of mRNAs in other metabolic pathways, viral reproduction, and oncogenesis.	Oxygen	98-104	Wnt family member 2	Homo sapiens	21-24
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit beta	Homo sapiens	32-45
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	173-177	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit beta	Homo sapiens	32-45
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-8	2000	Flow-cytometric analysis of the IL-2 receptor (CD25) showed that the normal downregulation kinetics - following stimulation-induced CD25 upregulation - were slowed under 5% O(2), such that the 5% O2 cultures had a greater number of CD25+ cells, and those CD25+ cells expressed an average (n = 6) of 41% higher levels of CD25 receptor per cell.	Oxygen	196-198	interleukin 2 receptor subunit alpha	Homo sapiens	132-136
12042052-12	2000	Evidence of increased IL-2R expression and reduced apoptosis levels under 5% O2 may help explain this phenomenon.	Oxygen	77-79	interleukin 2 receptor subunit alpha	Homo sapiens	22-27
10634624-0	2000	5" nucleotidase and adenosine during retinal vasculogenesis and oxygen-induced retinopathy.	Oxygen	64-70	5'-nucleotidase ecto	Canis lupus familiaris	0-15
10898220-3	2000	We examined the expression of hypoxia-inducible factor 1 (HIF-1), a potent transcriptional regulator of oxygen-dependent genes such as vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-beta), a potentially HIF-1-regulated scarring cytokine, on fetal and adult responses to wounding.	Oxygen	104-110	vascular endothelial growth factor A	Ovis aries	171-175
10898220-9	2000	Exposure of cultured fetal and adult dermal fibroblasts to hypoxia (1% O2) showed a marked induction of VEGF mRNA.	Oxygen	71-73	vascular endothelial growth factor A	Ovis aries	104-108
10636000-0	1999	Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment.	Oxygen	79-85	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	37-41
10583370-8	1999	Concomitantly, it accelerated oxygen consumption caused by activated nNOS.	Oxygen	30-36	nitric oxide synthase 1, neuronal	Mus musculus	69-73
10694037-6	1999	This was supported by the absence of changes in plants treated with Cd in the Mn-SOD activity, responsible for O2*- removal in the peroxisomal matrix.	Oxygen	111-115	superoxide dismutase 2	Homo sapiens	78-84
10557282-0	1999	Mass spectrometric determination of dioxygen bond splitting in the "peroxy" intermediate of cytochrome c oxidase.	Oxygen	36-44	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	92-112
9530169-2	1998	Incubation of tissues in 70% O2 resulted in a 133% increase in SP-A mRNA transcription rate compared with control tissues.	Oxygen	29-31	surfactant protein A1	Homo sapiens	63-67
9530169-3	1998	The SP-A mRNA half-life was increased by 54% in lung tissues cultured in 70% O2 vs. control tissues.	Oxygen	77-79	surfactant protein A1	Homo sapiens	4-8
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	72-74	surfactant protein A1	Homo sapiens	56-60
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	72-74	surfactant protein A1	Homo sapiens	122-126
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	72-74	surfactant protein A1	Homo sapiens	122-126
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	105-107	surfactant protein A1	Homo sapiens	56-60
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	105-107	surfactant protein A1	Homo sapiens	122-126
9530169-4	1998	Western blot analysis indicated a threefold increase in SP-A in the 70% O2 condition, demonstrating that O2 regulation of SP-A mRNA levels results in corresponding changes in SP-A levels.	Oxygen	105-107	surfactant protein A1	Homo sapiens	122-126
9530169-6	1998	Transcripts of both the SP-A1 and SP-A2 genes were increased approximately 100% in tissues maintained in 70% O2 compared with control tissues.	Oxygen	109-111	surfactant protein A1	Homo sapiens	24-29
9530169-7	1998	These data demonstrate that O2 regulates human SP-A mRNA levels by both transcriptional and posttranscriptional mechanisms.	Oxygen	28-30	surfactant protein A1	Homo sapiens	47-51
9517862-5	1998	Under hypoxic hypoxia, mean oxygen reactivity of CBF (relative change of CBF to a change of arterial oxygen content) was 7.8%/vol% in control animals and 3.3%/vol% after NOS inhibition (P &lt; 0.02).	Oxygen	28-34	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-52
9517862-5	1998	Under hypoxic hypoxia, mean oxygen reactivity of CBF (relative change of CBF to a change of arterial oxygen content) was 7.8%/vol% in control animals and 3.3%/vol% after NOS inhibition (P &lt; 0.02).	Oxygen	28-34	CCAAT/enhancer binding protein zeta	Rattus norvegicus	73-76
9517862-5	1998	Under hypoxic hypoxia, mean oxygen reactivity of CBF (relative change of CBF to a change of arterial oxygen content) was 7.8%/vol% in control animals and 3.3%/vol% after NOS inhibition (P &lt; 0.02).	Oxygen	101-107	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-52
9623808-0	1998	Time-resolved resonance Raman investigation of oxygen reduction mechanism of bovine cytochrome c oxidase.	Oxygen	47-53	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	84-104
9623808-1	1998	Six oxygen-associated resonance Raman bands were identified for intermediates in the reaction of bovine cytochrome c oxidase with O2 at room temperature.	Oxygen	4-10	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	104-124
9623808-1	1998	Six oxygen-associated resonance Raman bands were identified for intermediates in the reaction of bovine cytochrome c oxidase with O2 at room temperature.	Oxygen	130-132	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	104-124
9447969-1	1998	The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O2) conditions.	Oxygen	180-182	von Hippel-Lindau tumor suppressor	Homo sapiens	4-38
9447969-1	1998	The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O2) conditions.	Oxygen	180-182	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
9699005-3	1998	In order to assess the role of free radicals in cell signaling, we have studies the modulator effect of oxygen and nitrogen active species on liver methionine adenosyltransferase (MAT), a key metabolic enzyme.	Oxygen	104-110	methionine adenosyltransferase 1A	Homo sapiens	180-183
9699005-16	1998	On the basis of the metabolic implications of liver MAT, together with the structural features accounting for the sensitivity of this enzyme to active oxygen and nitrogen species, we propose that modulation of MAT by these agents could be a mechanism to regulate the consumption of ATP in the liver, and thus preserve cellular viability under different stress conditions.	Oxygen	151-157	methionine adenosyltransferase 1A	Homo sapiens	210-213
9473574-6	1998	Induction of YT521 mRNA was mediated by endogenously generated reactive oxygen species, as it was suppressed by treatment of the cells with diphenyl iodonium which blocks oxygen-free radical formation by astrocytes.	Oxygen	72-78	YTH domain containing 1	Rattus norvegicus	13-18
9616772-4	1997	They profoundly increase rCBF without changing rCGU and, hence, rapidly and efficiently provide the brain with oxygen.	Oxygen	111-117	CCAAT/enhancer binding protein zeta	Rattus norvegicus	25-29
9550424-10	1997	The electrogenic nature of the NADPH oxidase, i.e., its level of activation, being dependent on the plasmic membrane potential, might provide the causal link between the reactive oxygen intermediates generation and the opening of the K(Ca) channel.	Oxygen	179-185	casein kappa	Homo sapiens	234-239
9391125-6	1997	When heat shock protein (HSP) expression was examined after hypoxia, we observed a significant decrease in constitutive heat shock protein 70 (HSC 70) in RAW cells, but not in HARMs, as compared with the control normoxic condition (21% O2).	Oxygen	236-238	heat shock protein 8	Mus musculus	143-149
9409558-1	1997	Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen.	Oxygen	145-153	superoxide dismutase 2	Homo sapiens	0-30
9409558-1	1997	Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen.	Oxygen	145-153	superoxide dismutase 2	Homo sapiens	32-37
9587447-6	1997	Myocardial oxygen consumption is naturally increased during pregnancy and excess intracellular calcium secondary to the beta-1 stimulation occurring with the use of beta-2 mimetic drugs further aggravates matters.	Oxygen	11-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	165-171
9407434-9	1997	Using a chemiluminescence assay, we could detect increased O2- production by arteries pretreated with oxidized Lp(a), which suggested that enhanced nitric oxide (NO) inactivation by O2- might be the underlying mechanism of impairment of endothelium-dependent dilations.	Oxygen	59-61	lipoprotein(a)	Homo sapiens	111-116
9407434-9	1997	Using a chemiluminescence assay, we could detect increased O2- production by arteries pretreated with oxidized Lp(a), which suggested that enhanced nitric oxide (NO) inactivation by O2- might be the underlying mechanism of impairment of endothelium-dependent dilations.	Oxygen	182-184	lipoprotein(a)	Homo sapiens	111-116
9407434-12	1997	Coincubation with HDL significantly suppressed oxidized LDL and Lp(a) stimulated renin release and O2- production.	Oxygen	99-101	lipoprotein(a)	Homo sapiens	64-69
9447831-8	1997	Compared to the other components, p67phox was expressed late and its expression appeared to correlate most closely with the generation of O2- in the differentiation process.	Oxygen	138-140	neutrophil cytosolic factor 2	Homo sapiens	34-41
9398165-5	1997	The reaction of H2O2 and NHA with nNOS was at least 10-fold slower than the reaction of NADPH, O2, and NHA (Vmax,app = 49 +/- 2 nmol min-1 mg-1 for the reactions with 10 microM added H4B).	Oxygen	18-20	nitric oxide synthase 1	Homo sapiens	34-38
9362476-0	1997	Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes.	Oxygen	67-73	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	0-5
9374817-8	1997	We conclude that during chronic O2 deprivation, GLUT-1 and GLUT-4 expressions show a similar pattern but greatly depend on tissue type and age.	Oxygen	32-34	solute carrier family 2 member 1	Rattus norvegicus	48-54
9337622-8	1997	In phosphate buffer experiments, it was shown using electron spin resonance (ESR) associated with spin-trapping techniques that BCA is able to generate O2-.	Oxygen	152-154	B cell linker	Homo sapiens	128-131
9360228-8	1997	Both hCG and progesterone release rates were lowest at high oxygen tensions.	Oxygen	60-66	hypertrichosis 2 (generalised, congenital)	Homo sapiens	5-8
9360228-12	1997	Exposure to higher oxygen tensions results in reduced hCG and progesterone release.	Oxygen	19-25	hypertrichosis 2 (generalised, congenital)	Homo sapiens	54-57
9291182-3	1997	In human PTE, hypoxia (1% O2, 24 hr) increased total collagen production (15%), decreased MMP-2 activity (55% +/- 13%; control = 100%) and increased tissue inhibitor of metalloproteinase-1 (TIMP-1) protein.	Oxygen	26-28	matrix metallopeptidase 2	Homo sapiens	90-95
9867924-6	1997	Succinate dehydrogenase content and oxygen consumption in bFGF group were higher than those of the corresponding sites in the control group (P &lt; 0.05).	Oxygen	36-42	fibroblast growth factor 2	Rattus norvegicus	58-62
9867924-7	1997	It was suggested that the use of bFGF resulted in the decrease rate of necrosis of skin flap, and it maintained higher succinale dehydrogenase level and oxygen consumption.	Oxygen	153-159	fibroblast growth factor 2	Rattus norvegicus	33-37
9251819-0	1997	A myoglobin mutant designed to mimic the oxygen-avid Ascaris suum hemoglobin: elucidation of the distal hydrogen bonding network by solution NMR.	Oxygen	41-47	myoglobin	Physeter catodon	2-11
9252501-5	1997	Leptin increased oxygen consumption after the 5th and 6th days in ad libitum-fed rats and after the 4th, 5th, and 6th days in food-restricted rats.	Oxygen	17-23	leptin	Rattus norvegicus	0-6
9298245-6	1997	The insulin-dependent activation of the glucokinase (GK) gene was reciprocally modulated by oxygen.	Oxygen	92-98	glucokinase	Rattus norvegicus	40-51
9298245-6	1997	The insulin-dependent activation of the glucokinase (GK) gene was reciprocally modulated by oxygen.	Oxygen	92-98	glucokinase	Rattus norvegicus	53-55
9298245-7	1997	Exogenously added hydrogen peroxide mimicked the effects of arterial oxygen on both the glucagon-dependent PCK gene and the insulin-dependent GK activation.	Oxygen	69-75	glucokinase	Rattus norvegicus	142-144
9298245-13	1997	Oxidative conditions such as H2O2 reduced the DNA-binding activity, thus supporting the role of H2O2 as a mediator in the O2 response of the PCK and GK genes.	Oxygen	31-33	glucokinase	Rattus norvegicus	149-151
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	128-132
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	134-138
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	140-145
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	119-121	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	24-28
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	119-121	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	30-35
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	119-121	cytochrome c oxidase subunit VIII	Saccharomyces cerevisiae S288C	43-47
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	138-144	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	24-28
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	138-144	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	30-35
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	138-144	cytochrome c oxidase subunit VIII	Saccharomyces cerevisiae S288C	43-47
9169434-8	1997	For others (COX5a and CYC1) the level of expression is nearly constant between 200 microM O2 and their threshold and then drops off.	Oxygen	90-92	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	12-17
9169434-9	1997	The hypoxic genes COX5b and CYC7 are not expressed until the oxygen concentration is below 0.5 microM O2.	Oxygen	61-67	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	28-32
9169434-9	1997	The hypoxic genes COX5b and CYC7 are not expressed until the oxygen concentration is below 0.5 microM O2.	Oxygen	102-104	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	28-32
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	280-286	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	38-43
9202456-0	1997	Targeted gene-replacement mutagenesis of dcrA, encoding an oxygen sensor of the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.	Oxygen	59-65	dcrA	Desulfovibrio vulgaris str. Hildenborough	41-45
9202456-1	1997	A gene-replacement mutagenesis method has been developed for the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough and used to delete dcrA, encoding a potential oxygen or redox sensor with homology to the methyl-accepting chemotaxis proteins.	Oxygen	186-192	dcrA	Desulfovibrio vulgaris str. Hildenborough	159-163
18634086-8	1997	2.3 g/L) for beta-galactosidase under elevated oxygen have been obtained.	Oxygen	47-53	galactosidase beta 1	Homo sapiens	13-31
10582858-10	1999	Partial pressures of oxygen required for various degrees of hemoglobin saturation were higher in meconium-exposed samples; P50 (30.1+/-0.6 vs. 27.8+/-0.4 mmHg, P &lt; 0.01); P75 (46.9+/-0.6 vs. 43.1+/-0.5 mmHg, P &lt; .001); P90 (69.2+/-1 vs. 63.3+/-1 mmHg, P &lt; 0.01).	Oxygen	21-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	174-177
10493928-1	1999	Oxalate oxidase (EC 1.2.3.4) catalyses the conversion of oxalate and dioxygen into CO(2) and H(2)O(2).	Oxygen	69-77	LOC548260	Hordeum vulgare	0-15
10493928-3	1999	The involvement of Mn and neither flavin, Cu nor Fe in the direct conversion of dioxygen to H(2)O(2) makes oxalate oxidase unique.	Oxygen	80-88	LOC548260	Hordeum vulgare	107-122
10932692-2	1999	The Bird Ventilator Mark 2 is utilised as an oxygen pressure jet to drive an injector placed at the distal end of the double T-piece breathing system.	Oxygen	45-51	microtubule affinity regulating kinase 2	Homo sapiens	20-26
10488097-3	1999	Evidence that this fragmentation is oxygen-mediated includes the findings that aerobically (but not anaerobically) grown sod1Delta yeast exhibit aberrant vacuoles and genetic suppressors of other oxygen-dependent sod1 null phenotypes rescue the vacuole defect.	Oxygen	36-42	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	121-125
10488097-3	1999	Evidence that this fragmentation is oxygen-mediated includes the findings that aerobically (but not anaerobically) grown sod1Delta yeast exhibit aberrant vacuoles and genetic suppressors of other oxygen-dependent sod1 null phenotypes rescue the vacuole defect.	Oxygen	36-42	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	213-217
10488097-3	1999	Evidence that this fragmentation is oxygen-mediated includes the findings that aerobically (but not anaerobically) grown sod1Delta yeast exhibit aberrant vacuoles and genetic suppressors of other oxygen-dependent sod1 null phenotypes rescue the vacuole defect.	Oxygen	196-202	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	121-125
10488097-3	1999	Evidence that this fragmentation is oxygen-mediated includes the findings that aerobically (but not anaerobically) grown sod1Delta yeast exhibit aberrant vacuoles and genetic suppressors of other oxygen-dependent sod1 null phenotypes rescue the vacuole defect.	Oxygen	196-202	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	213-217
10487921-12	1999	Thus, the activation of ATF1 transcription is dependent on Rap1p, and the Rox1p-Tup1p-Ssn6p hypoxic repressor complex is responsible for repression by oxygen.	Oxygen	151-157	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	80-85
10487921-12	1999	Thus, the activation of ATF1 transcription is dependent on Rap1p, and the Rox1p-Tup1p-Ssn6p hypoxic repressor complex is responsible for repression by oxygen.	Oxygen	151-157	transcription regulator CYC8	Saccharomyces cerevisiae S288C	86-91
10511315-4	1999	Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition.	Oxygen	23-29	superoxide dismutase 2	Homo sapiens	95-100
10511315-4	1999	Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition.	Oxygen	23-29	superoxide dismutase 2	Homo sapiens	160-165
10511315-4	1999	Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition.	Oxygen	118-124	superoxide dismutase 2	Homo sapiens	95-100
10511315-4	1999	Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition.	Oxygen	118-124	superoxide dismutase 2	Homo sapiens	160-165
10446187-3	1999	In Hep3B human hepatoma cells incubated in 1% O(2) or treated with CoCl(2), which mimics hypoxia, we detected a 3-fold increase of TfR mRNA despite a decrease of iron regulatory proteins activity.	Oxygen	46-50	transferrin receptor	Homo sapiens	131-134
9142151-1	1997	BACKGROUND: Intestinal ischemic injury is exacerbated by reperfusion in rodent and feline models because of xanthine oxidase-initiated reactive oxygen metabolite formation and neutrophil infiltration.	Oxygen	144-150	xanthine dehydrogenase	Sus scrofa	108-124
19280118-7	2009	Real-time RT-PCR demonstrated that the SDF-1 mRNA level in AtT20 cells was significantly increased at 1% oxygen (logarithmic mean value = 1.55 +/- 0.56) compared with that at 21% oxygen.	Oxygen	105-111	chemokine (C-X-C motif) ligand 12	Mus musculus	39-44
9173872-1	1997	Nitric oxide synthase (EC 1.14.13.39) catalyses the conversion of arginine, NADPH and oxygen to nitric oxide and citrulline, using haem, (6R)-5,6,7,8-tetrahydro-l-biopterin (tetrahydrobiopterin), calmodulin, FAD and FMN as cofactors.	Oxygen	86-92	calmodulin 1	Rattus norvegicus	196-206
10524036-0	1999	Management of COPD with oxygen therapy at home.	Oxygen	24-30	COPD	Homo sapiens	14-18
19280118-7	2009	Real-time RT-PCR demonstrated that the SDF-1 mRNA level in AtT20 cells was significantly increased at 1% oxygen (logarithmic mean value = 1.55 +/- 0.56) compared with that at 21% oxygen.	Oxygen	179-185	chemokine (C-X-C motif) ligand 12	Mus musculus	39-44
19587118-4	2009	We show here that nuclear export is mediated in part by a CRM1-dependent nuclear export signal localized in the oxygen-dependent degradation domain (ODDD).	Oxygen	112-118	embargoed	Drosophila melanogaster	58-62
19587118-5	2009	CRM1-dependent nuclear export requires both oxygen-dependent hydroxylation of a specific prolyl residue (Pro850) in the ODDD, and the activity of the von Hippel Lindau tumor suppressor factor.	Oxygen	44-50	embargoed	Drosophila melanogaster	0-4
10393722-14	1999	IMPLICATIONS: 4-HPR may form the basis for a novel, p53-independent chemotherapy that operates through increased intracellular levels of ceramide and that retains cytotoxicity under reduced oxygen conditions.	Oxygen	190-196	haptoglobin-related protein	Homo sapiens	16-19
9124510-0	1997	Inhibition of human neutrophil beta2-integrin-dependent adherence by hyperbaric O2.	Oxygen	80-82	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	31-36
19616332-8	2009	When treated with 7% oxygen breathing, a 3-fold higher CAI accumulation (P&lt;0.01) was observed.	Oxygen	21-27	carbonic anhydrase 9	Homo sapiens	55-58
9038162-2	1997	glut1 is also up-regulated by inhibitors of oxidative phosphorylation (such as azide) in the presence of oxygen.	Oxygen	105-111	solute carrier family 2 member 1	Rattus norvegicus	0-5
9038162-4	1997	We examined the effect of cobalt chloride, a known stimulator of genes responsive to reduced oxygen concentration per se, on GLUT1 expression under normoxic conditions and compared the results with the response to azide.	Oxygen	93-99	solute carrier family 2 member 1	Rattus norvegicus	125-130
10385588-4	1999	Further, CD10/NEP messenger RNA levels parallelled relative PNEC numbers in DEN/O2-treated hamster lung, suggesting that the enzyme might mediate spontaneous regression of PNEC hyperplasia.	Oxygen	80-82	membrane metallo endopeptidase	Mus musculus	9-13
10385588-4	1999	Further, CD10/NEP messenger RNA levels parallelled relative PNEC numbers in DEN/O2-treated hamster lung, suggesting that the enzyme might mediate spontaneous regression of PNEC hyperplasia.	Oxygen	80-82	membrane metallo endopeptidase	Mus musculus	14-17
10425542-7	1999	In addition, the increased SP and CGRP fibers around the laryngeal gland suggest an enhanced mucous secretion, and this may participate in the airway defense mechanism in low O2 conditions.	Oxygen	175-177	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
9028967-5	1997	Antisense oligonucleotide for hGATA-2 transcription factor significantly increased the Epo protein in Hep3B cells under 1% O2 for 24 hours incubation.	Oxygen	123-125	GATA binding protein 2	Homo sapiens	30-37
9027720-6	1997	The mRNA levels of flt-1 were up-regulated threefold by 8% O2 in livers, dependent on the strength of hypoxia (10% caused no changes in flt-1 gene expression) and on the kind of hypoxic stimulus (8% O2 was as effective as 0.1% CO and more effective than cobalt).	Oxygen	59-61	Fms related receptor tyrosine kinase 1	Rattus norvegicus	19-24
9027720-6	1997	The mRNA levels of flt-1 were up-regulated threefold by 8% O2 in livers, dependent on the strength of hypoxia (10% caused no changes in flt-1 gene expression) and on the kind of hypoxic stimulus (8% O2 was as effective as 0.1% CO and more effective than cobalt).	Oxygen	199-201	Fms related receptor tyrosine kinase 1	Rattus norvegicus	19-24
9027744-0	1997	Post-transcriptional regulation of tyrosine hydroxylase gene expression by oxygen in PC12 cells.	Oxygen	75-81	tyrosine hydroxylase	Rattus norvegicus	35-55
9027744-1	1997	Reduced oxygen tension (hypoxia) leads to increased stability of mRNA for tyrosine hydroxylase (TH), the rate limiting enzyme in biosynthesis of catecholamine neurotransmitters.	Oxygen	8-14	tyrosine hydroxylase	Rattus norvegicus	74-94
10407265-0	1999	Deletion of the carbonic anhydrase-like gene NCE103 of the yeast Saccharomyces cerevisiae causes an oxygen-sensitive growth defect.	Oxygen	100-106	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	45-51
9027744-1	1997	Reduced oxygen tension (hypoxia) leads to increased stability of mRNA for tyrosine hydroxylase (TH), the rate limiting enzyme in biosynthesis of catecholamine neurotransmitters.	Oxygen	8-14	tyrosine hydroxylase	Rattus norvegicus	96-98
10407265-4	1999	A nce103-Delta deletion strain did not grow on a rich peptone-yeast extract-glucose medium under normal aerobic conditions at pH values of 3.0-8.0, but grew like wild-type in an oxygen-free nitrogen or oxygen-reduced atmosphere over this pH range, and was more sensitive to H(2)O(2) than wild-type.	Oxygen	178-184	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	2-8
19449392-5	2009	Therefore, the focus of this study is to investigate how baffling and the well geometry affect the maximum oxygen transfer capacity (OTR(max)) in microtiter plates.	Oxygen	107-113	oxytocin receptor	Homo sapiens	133-136
10407265-4	1999	A nce103-Delta deletion strain did not grow on a rich peptone-yeast extract-glucose medium under normal aerobic conditions at pH values of 3.0-8.0, but grew like wild-type in an oxygen-free nitrogen or oxygen-reduced atmosphere over this pH range, and was more sensitive to H(2)O(2) than wild-type.	Oxygen	202-208	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	2-8
10387045-12	1999	Compared with ferrous-O2 P450-CAM, however, the ferrous-O2 adduct of the nNOS oxygenase domain is considerably more autoxidizable and the O2-CO exchange reaction is noticeably slower.	Oxygen	22-24	nitric oxide synthase 1	Homo sapiens	73-77
8956285-12	1996	A reduced secretory capacity of E2 and inhibin was demonstrated for follicles cultured under 5% O2.	Oxygen	96-98	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	32-46
19542490-5	2009	To test the hypothesis that reduced oxygen tension can directly stimulate BNP gene expression and release in the absence of hemodynamic or neurohormonal stimuli, we used an in vitro model system of cultured human ventricular myocytes (AC16 cells).	Oxygen	36-42	natriuretic peptide B	Homo sapiens	74-77
8990886-1	1996	To evaluate cerebral oxygen desaturation during retrograde cerebral perfusion with total circulatory arrest (RCP), we measured cerebral oxygen extraction (O2 Ext), and arterio-venous oxygen differences (AV DO2) during and after RCP and compared the results with usual cardiopulmonary bypass (CPB) using continuous jugular blood saturation (SjO2) monitoring.	Oxygen	21-27	CGRP receptor component	Homo sapiens	109-112
8990886-9	1996	O2 Ext in the RCP group was significantly higher than in the CPB group during and after rewarming.	Oxygen	0-2	CGRP receptor component	Homo sapiens	14-17
8990886-13	1996	In conclusion, continuous SjO2 measurements reflected cerebral oxygen desaturation during and after rewarming in RCP.	Oxygen	63-69	CGRP receptor component	Homo sapiens	113-116
10364186-5	1999	This rise in oxygen consumption was associated with an increase in NRF-1 mRNA.	Oxygen	13-19	nuclear respiratory factor 1	Homo sapiens	67-72
10352037-0	1999	Kvbeta1.2 subunit coexpression in HEK293 cells confers O2 sensitivity to kv4.2 but not to Shaker channels.	Oxygen	55-57	potassium voltage-gated channel subfamily D member 2	Homo sapiens	73-78
19540258-4	2009	In the ber ner strain, Rad53 phosphorylation can be abolished by inclusion of antioxidants or exclusion of oxygen.	Oxygen	107-113	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	23-28
10352037-8	1999	Finally, hypoxic inhibition of Kv4.2+beta currents can be reverted by 70% in the presence of carbon monoxide and remains in cell-free patches, suggesting the presence of a hemoproteic O2 sensor in HEK293 cells and a membrane-delimited mechanism at the origin of hypoxic responses.	Oxygen	184-186	potassium voltage-gated channel subfamily D member 2	Homo sapiens	31-36
8903482-1	1996	Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2-.	Oxygen	88-90	superoxide dismutase 2	Homo sapiens	0-30
8903482-1	1996	Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2-.	Oxygen	88-90	superoxide dismutase 2	Homo sapiens	32-37
19392705-0	2009	VERNALIZATION INSENSITIVE 3 (VIN3) is required for the response of Arabidopsis thaliana seedlings exposed to low oxygen conditions.	Oxygen	113-119	Fibronectin type III domain-containing protein	Arabidopsis thaliana	0-27
8916817-11	1996	RESULTS: Isoflurane and desflurane in both 50% oxygen-nitrous oxide and 100% oxygen were associated with a significant decrease in the amplitude and an increase in the latency of the cortical P40, whereas subcortical P29 latency did not vary significantly.	Oxygen	47-53	interleukin 9	Homo sapiens	192-195
11900648-4	1999	RESULTS: FDP could significantly increase MAP and the survival rate, elevate pH value, partial oxygen pressure (PaO(2)) and superoxide dismutase (SOD) activity, and decrease partial carbon dioxide pressure (PaCO(2)) and malondialdehyde (MDA) in arterial blood of the shocked animals.	Oxygen	95-101	fructose-bisphosphatase 1	Rattus norvegicus	9-12
19392705-0	2009	VERNALIZATION INSENSITIVE 3 (VIN3) is required for the response of Arabidopsis thaliana seedlings exposed to low oxygen conditions.	Oxygen	113-119	Fibronectin type III domain-containing protein	Arabidopsis thaliana	29-33
10218962-12	1999	Oxygen consumption was significantly increased (32.1 +/- 7.4%) in BAT (139.0 +/- 8.2 nmole O2/30 min x 10(6) cells) of leptin-treated rats vs. that in V control rats (105.3 +/- 6.7 nmole O2/30 min x 10(6) cells).	Oxygen	91-93	leptin	Rattus norvegicus	119-125
19392705-6	2009	Complementation of the vin3 mutant with a VIN3 transgene restored the wild-type response to low oxygen and confirmed the role of VIN3 in protecting both shoots and roots during low oxygen conditions.	Oxygen	96-102	Fibronectin type III domain-containing protein	Arabidopsis thaliana	23-27
10218962-12	1999	Oxygen consumption was significantly increased (32.1 +/- 7.4%) in BAT (139.0 +/- 8.2 nmole O2/30 min x 10(6) cells) of leptin-treated rats vs. that in V control rats (105.3 +/- 6.7 nmole O2/30 min x 10(6) cells).	Oxygen	0-6	leptin	Rattus norvegicus	119-125
10218962-13	1999	In conclusion, leptin has differential, tissue-specific effects on glucose and oxygen utilization, which contribute to the reduction in whole body adiposity by enhancing energy consumption in BAT and muscle while attenuating energy storage in WAT.	Oxygen	79-85	leptin	Rattus norvegicus	15-21
9933651-3	1999	Using the human hepatoma cell line Hep3B as a model, we found that 16 h in a 1% oxygen atmosphere markedly increases IRE/IRP-1 binding as assessed by electromobility shift assay.	Oxygen	80-86	aconitase 1	Homo sapiens	121-126
9933651-11	1999	273, 7588-7593) in which a 3% oxygen atmosphere reduced IRE/IRP-1 binding in rat hepatoma cells.	Oxygen	30-36	aconitase 1	Rattus norvegicus	60-65
8913477-1	1996	The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with ribavirin.	Oxygen	4-10	superoxide dismutase 2	Homo sapiens	52-82
8913477-1	1996	The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with ribavirin.	Oxygen	4-10	superoxide dismutase 2	Homo sapiens	84-89
8896427-1	1996	Nitric oxide (NO) generated from L-arginine and molecular oxygen by nitric oxide synthase (NOS) has been shown to influence hepatocellular function and pathology in response to ischemia and certain hepatotoxins.	Oxygen	58-64	nitric oxide synthase 1, neuronal	Mus musculus	68-89
9890961-10	1999	This double substitution occurs naturally in the myoglobin of Asian elephants, and similar multiple replacements have been used to reduce selectively the rate of nitric oxide (NO)-induced oxidation of both recombinant MbO2 and HbO2 blood substitute prototypes without altering O2 affinity.	Oxygen	220-222	myoglobin	Physeter catodon	49-58
19392705-6	2009	Complementation of the vin3 mutant with a VIN3 transgene restored the wild-type response to low oxygen and confirmed the role of VIN3 in protecting both shoots and roots during low oxygen conditions.	Oxygen	96-102	Fibronectin type III domain-containing protein	Arabidopsis thaliana	42-46
8921003-1	1996	Mammalian phenylalanine hydroxylase (PAH) catalyses the conversion of L-phenylalanine to L-tyrosine in the presence of dioxygen and tetrahydrobiopterin; it is a highly regulated enzyme.	Oxygen	119-127	phenylalanine hydroxylase	Homo sapiens	10-35
19392705-6	2009	Complementation of the vin3 mutant with a VIN3 transgene restored the wild-type response to low oxygen and confirmed the role of VIN3 in protecting both shoots and roots during low oxygen conditions.	Oxygen	181-187	Fibronectin type III domain-containing protein	Arabidopsis thaliana	23-27
8921003-1	1996	Mammalian phenylalanine hydroxylase (PAH) catalyses the conversion of L-phenylalanine to L-tyrosine in the presence of dioxygen and tetrahydrobiopterin; it is a highly regulated enzyme.	Oxygen	119-127	phenylalanine hydroxylase	Homo sapiens	37-40
19392705-6	2009	Complementation of the vin3 mutant with a VIN3 transgene restored the wild-type response to low oxygen and confirmed the role of VIN3 in protecting both shoots and roots during low oxygen conditions.	Oxygen	181-187	Fibronectin type III domain-containing protein	Arabidopsis thaliana	42-46
10579226-8	1999	SR 140333 reduced Fos-like immunoreactivity induced by [Sar9,Met(O2)11]substance P in most areas.	Oxygen	65-67	proto-oncogene c-Fos	Cavia porcellus	18-21
19478336-5	2009	The rate of superoxide generation by the reconstituted bc(1) complex increased exponentially with increased magnitude of the membrane potential, a finding that is compatible with the suggestion that membrane potential inhibits electron transfer from the cytochrome b(L) to b(H) hemes, thereby promoting the formation of a ubisemiquinone radical that interacts with oxygen to generate superoxide.	Oxygen	365-371	cytochrome b	Saccharomyces cerevisiae S288C	254-266
9876872-9	1998	Neurotrophic factors such as nerve growth factor (NGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF) blocked the apoptosis induced by a high-oxygen atmosphere.	Oxygen	162-168	epidermal growth factor like 1	Rattus norvegicus	92-115
8887660-1	1996	Oxygen toxicity in Saccharomyces cerevisiae lacking the copper/zinc superoxide dismutase (SOD1) can be suppressed by overexpression of the S. cerevisiae ATX2 gene.	Oxygen	0-6	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	90-94
19584355-0	2009	Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.	Oxygen	0-6	von Hippel-Lindau tumor suppressor	Homo sapiens	90-94
8855223-5	1996	Thus, pVHL appears to play a critical role in the transduction of signals generated by changes in ambient oxygen tension.	Oxygen	106-112	von Hippel-Lindau tumor suppressor	Homo sapiens	6-10
9843154-8	1998	Isobaric hyperoxia stimulated APE/Ref-1 expression in the hippocampus and basal forebrain of young rats experiencing 100% oxygen for 6 hr, while aged rats showed no significant changes in APE/Ref-1 protein levels in all brain areas at any time tested (0-48 hr) after hyperoxia.	Oxygen	122-128	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	30-33
19555296-1	2009	Hypoxia-induced hyperventilation is critical to improve blood oxygenation, particularly when the arterial Po2 lies in the steep region of the O2 dissociation curve of the hemoglobin (ODC).	Oxygen	142-144	ornithine decarboxylase 1	Homo sapiens	183-186
10225413-9	1998	The total oxygen consumption was the same for the three exercise bouts, but when it is corrected for the total work performed, oxygen uptake during EX2 (153 +/- 9 ml x KJ(-1)) and EX3 (150 +/- 9 ml x KJ(-1)) was higher (p &lt; 0.01 and p &lt; 0.05, respectively) than during EX1 (139 +/- 8 ml x KJ(-1)).	Oxygen	127-133	FERM domain containing 6	Homo sapiens	275-278
8876933-1	1996	The antioxidant effects of ceruloplasmin (CAS 9031-37-2) against oxygen free radicals (.O2-, .OH, 1O2) and their by-products (H2O2, HOCl), generated by electrolysis of Krebs-Henseleit buffer, were determined in vitro by the DPD (N,N-diethyl-p-phenylenediamine) colorimetric method and ex vivo by quantifying cardiodynamic variables of the isolated perfused rat heart.	Oxygen	88-90	ceruloplasmin	Rattus norvegicus	27-40
8806457-1	1996	We have studied the role of the retinoblastoma susceptibility gene product (pRB) in the regulation of cell-cycle progression under extremely hypoxic conditions (&lt; 4 ppm O2).	Oxygen	172-174	RB transcriptional corepressor 1	Homo sapiens	76-79
9857275-5	1998	RESULTS: Patients with COPD had a decrease in peak oxygen consumption compared with healthy subjects (1.2 +/- 0.1 versus 3.0 +/- 0.2 L/min).	Oxygen	51-57	COPD	Homo sapiens	23-27
19448429-5	2009	Low oxygen levels result in strongly increased HIPK2/Siah2 interactions that lead to efficient polyubiquitylation and proteasomal degradation of the kinase.	Oxygen	4-10	siah E3 ubiquitin protein ligase 2	Homo sapiens	53-58
9790820-2	1998	One of the mechanisms involved in the decrease of endogenous bFGF is the increased destruction of this growth factor associated with oxygen free radical activation and inflammation.	Oxygen	133-139	fibroblast growth factor 2	Rattus norvegicus	61-65
8702521-0	1996	Molecular oxygen modulates cytochrome c oxidase function.	Oxygen	10-16	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	27-47
8702521-1	1996	This study sought to determine whether molecular oxygen interacts with cytochrome c oxidase to modify its catalytic activity.	Oxygen	49-55	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	71-91
8702521-3	1996	Oxidized bovine heart cytochrome c oxidase was incubated in oxygen concentrations of &lt;50 microM for 4 h. The enzyme exhibited a reversible decrease in Vmax after incubation, compared with control enzyme incubated at higher oxygen concentrations.	Oxygen	60-66	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-42
8702521-3	1996	Oxidized bovine heart cytochrome c oxidase was incubated in oxygen concentrations of &lt;50 microM for 4 h. The enzyme exhibited a reversible decrease in Vmax after incubation, compared with control enzyme incubated at higher oxygen concentrations.	Oxygen	226-232	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-42
8702521-6	1996	These results provide a mechanistic explanation for the observation that intact cells or mitochondria exhibit a reversible inhibition of respiration during prolonged exposure to [O2] &lt;25 mM, by demonstrating that the catalytic activity of cytochrome c oxidase function is similarly inhibited, possibly through an allosteric effect of molecular O2 on the enzyme.	Oxygen	179-181	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	242-262
8770104-3	1996	Both rat AM (0.2-10 nmol) and alpha-CGRP (0.2-2 nmol) produced dose-related reductions in pulmonary artery pressure in the isolated perfused lung ventilated with 2% O2.	Oxygen	165-167	calcitonin-related polypeptide alpha	Rattus norvegicus	36-40
9748268-8	1998	Reducing the ambient oxygen concentration or treatment with a cell-permeant H2O2 scavenger prevented Id1-stimulated apoptosis in cardiac myocytes.	Oxygen	21-27	inhibitor of DNA binding 1, HLH protein	Homo sapiens	101-104
19545664-5	2009	RESULTS: Compared with control livers, CGRP-treated organs showed significantly decreased alanine aminotransferase (ALT) and glutamate-lactate dehydrogenase (GLDH) leakage and portal venous pressure (2.0 +/- 0.3 vs 4.0 +/- 0.4 mmHg; P &lt; .01), with significantly increased bile production (8.56 +/- 0.76 vs 3.34 +/- 0.68 microL/g/45 min; P &lt; .01), oxygen consumption (5.14 +/- 0.4 vs 2.57 +/- 0.2 microL/g/min; P &lt; .01), and total adenine nucleotides (TAN) (11.1 +/- 0.71 vs 7.02 +/- 0.53 micromol/g; P &lt; .01) upon reperfusion as signs of recovered viability.	Oxygen	353-359	calcitonin-related polypeptide alpha	Rattus norvegicus	39-43
9811178-4	1998	Changes in oxygenation were assessed using arterial-alveolar oxygen tension ratio (a/APO2) and oxygenation index (OI) during HFOV.	Oxygen	11-17	TNF receptor superfamily member 10a	Homo sapiens	85-89
8679627-1	1996	Several species of marine tunicates store oxygen-sensitive VIII in blood cells.	Oxygen	42-48	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
9926166-0	1998	The value of forced expiratory volume in 1 s in screening subjects with stable COPD for PaO2 &lt; 7.3 kPa qualifying for long-term oxygen therapy.	Oxygen	131-137	COPD	Homo sapiens	79-83
19321442-0	2009	PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.	Oxygen	93-99	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	15-43
9926166-1	1998	Guidelines on the management of chronic obstructive pulmonary disease (COPD) issued by the European Respiratory Society (ERS), British Thoracic Society (BTS), American Thoracic Society (ATS), and Department of Health for England and Wales (DoH) suggest differing values of forced expiratory volume in 1 s (FEV1) below which arterial blood gas analysis should be performed to determine the presence of severe hypoxaemia and possible long-term oxygen therapy (LTOT) requirement.	Oxygen	442-448	COPD	Homo sapiens	71-75
8679214-6	1996	Northern blot analysis of lung mRNA isolated at 96 h of oxygen exposure revealed a 7-fold increase in CD54 (intercellular adhesion molecule-1 [ICAM-1]) and a 2.5-fold increase in TNF-alpha mRNAs respectively.	Oxygen	56-62	intercellular adhesion molecule 1	Mus musculus	102-106
8679214-6	1996	Northern blot analysis of lung mRNA isolated at 96 h of oxygen exposure revealed a 7-fold increase in CD54 (intercellular adhesion molecule-1 [ICAM-1]) and a 2.5-fold increase in TNF-alpha mRNAs respectively.	Oxygen	56-62	intercellular adhesion molecule 1	Mus musculus	108-141
8679214-6	1996	Northern blot analysis of lung mRNA isolated at 96 h of oxygen exposure revealed a 7-fold increase in CD54 (intercellular adhesion molecule-1 [ICAM-1]) and a 2.5-fold increase in TNF-alpha mRNAs respectively.	Oxygen	56-62	intercellular adhesion molecule 1	Mus musculus	143-149
19321442-0	2009	PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.	Oxygen	93-99	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	45-50
9802567-0	1998	The psbO gene for 33-kDa precursor polypeptide of the oxygen-evolving complex in Arabidopsis thaliana--nucleotide sequence and control of its expression.	Oxygen	54-60	PS II oxygen-evolving complex 1	Arabidopsis thaliana	4-8
19321442-1	2009	Oxygen and glucose deprivation (OGD) induces delayed cell death in hippocampal CA1 neurons via Ca(2+)/Zn(2+)-permeable, GluR2-lacking AMPA receptors (AMPARs).	Oxygen	0-6	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	120-125
19358330-8	2009	1% oxygen-mediated apoptosis was significantly inhibited in FGFR2-Tg-ECs and this inhibition was abolished by PI3-kinase inhibitor.	Oxygen	3-9	fibroblast growth factor receptor 2	Mus musculus	60-65
9700103-4	1998	HDC transcripts were decreased approximately 73% with dexamethasone treatment, 57% with corticosterone treatment, and 50% with exposure to 10% oxygen.	Oxygen	143-149	histidine decarboxylase	Rattus norvegicus	0-3
9700103-5	1998	Likewise, HDC enzyme activity was decreased 80% by treatment with dexamethasone and corticosterone and 60% by exposure to 10% oxygen.	Oxygen	126-132	histidine decarboxylase	Rattus norvegicus	10-13
8668195-8	1996	Finally, we demonstrate that biologically synthesized NO regulates the expression of IRE-containing mRNAs in target cells by passive diffusion and that oxidative stress endogenously generated by pharmacological modulation of the mitochondrial respiratory chain activates IRP-1, underscoring the physiological significance of NO and reactive oxygen intermediates as regulators of cellular iron metabolism.	Oxygen	341-347	aconitase 1	Homo sapiens	271-276
9700103-6	1998	Adrenalectomy prevented the decreases in HDC mRNA and enzyme activity observed in rats exposed to 10% oxygen, suggesting that the adrenal gland is necessary for the mediation of hypoxic effects on HDC gene expression.	Oxygen	102-108	histidine decarboxylase	Rattus norvegicus	41-44
19358330-9	2009	FGFR2-Tg-ECs exposed to 1% oxygen exhibited enhanced phosphorylation of 416-Tyr-Src, 473-Ser-Akt, and HIF1alpha accumulation.	Oxygen	27-33	fibroblast growth factor receptor 2	Mus musculus	0-5
9700103-6	1998	Adrenalectomy prevented the decreases in HDC mRNA and enzyme activity observed in rats exposed to 10% oxygen, suggesting that the adrenal gland is necessary for the mediation of hypoxic effects on HDC gene expression.	Oxygen	102-108	histidine decarboxylase	Rattus norvegicus	197-200
8832531-5	1996	After adjustment for age, gender, and weight, the relative hazard rates (RHR; Cox regression) of peak oxygen uptake (l.min-1) amounted to 0.44 (P = 0.01) for the first occurring cardiovascular events and 0.35 (P = 0.05) for all-cause mortality.	Oxygen	102-108	cytochrome c oxidase subunit 8A	Homo sapiens	78-81
19232363-2	2009	We previously reported that soluble (s) forms of EphB4 and ephrinB2 significantly reduced retinal NV in a model of oxygen-induced retinopathy.	Oxygen	115-121	EPH receptor B4	Homo sapiens	49-54
11667330-3	1996	In all the examined cases boroxy nitroxides, RN(O(*))OBLH(2), resulting from the addition of ligated boryl radicals, LBH(2)(*), to an oxygen atom of the nitro group were detected and characterized by EPR spectroscopy.	Oxygen	134-140	LBH regulator of WNT signaling pathway	Homo sapiens	117-120
9687445-1	1998	The rbo gene of Desulfovibrio vulgaris Hildenborough encodes rubredoxin oxidoreductase (Rbo), a 14-kDa iron sulfur protein; forms an operon with the gene for rubredoxin; and is preceded by the gene for the oxygen-sensing protein DcrA.	Oxygen	206-212	DVU3184	Desulfovibrio vulgaris str. Hildenborough	61-71
9696974-8	1998	Measured pHi correlated positively with mixed venous O2 tension (r = 0.21).	Oxygen	53-55	glucose-6-phosphate isomerase	Homo sapiens	9-12
9696974-9	1998	There were significant negative correlations between measured pHi and both oxygen delivery (r = -0.25) and oxygen consumption (r = 0.28).	Oxygen	75-81	glucose-6-phosphate isomerase	Homo sapiens	62-65
9696974-9	1998	There were significant negative correlations between measured pHi and both oxygen delivery (r = -0.25) and oxygen consumption (r = 0.28).	Oxygen	107-113	glucose-6-phosphate isomerase	Homo sapiens	62-65
9696974-12	1998	Arterial blood pressure and mixed venous oxygen saturation correlated better with measured pHi than with other indices of perfusion.	Oxygen	41-47	glucose-6-phosphate isomerase	Homo sapiens	91-94
16535328-9	1996	The positive reaction to nitrate overruled a negative response to oxygen, indicating that nitrate is the principal electron acceptor used by Thioploca spp.	Oxygen	66-72	histocompatibility minor 13	Homo sapiens	151-154
19233899-4	2009	These kinetic properties of compounds 1 and 7 against TK-2 could be accounted for by molecular modeling showing that two hydrogen bonds can be formed between the thiourea nitrogens of compound 7 and the oxygens of the gamma-phosphate of ATP.	Oxygen	203-210	thymidine kinase 2	Homo sapiens	54-58
8641834-6	1996	Hypoxia decreased KDR gene expression in a dose-and time-dependent manner with maximal inhibition to 0.5 +/- 0.2% (P = 0.019) of normoxic control observed after 24 hours exposure to 0% oxygen and with significant inhibition at oxygen concentrations below 5%.	Oxygen	185-191	kinase insert domain receptor	Bos taurus	18-21
8641834-6	1996	Hypoxia decreased KDR gene expression in a dose-and time-dependent manner with maximal inhibition to 0.5 +/- 0.2% (P = 0.019) of normoxic control observed after 24 hours exposure to 0% oxygen and with significant inhibition at oxygen concentrations below 5%.	Oxygen	227-233	kinase insert domain receptor	Bos taurus	18-21
8641834-7	1996	Blockade of oxygen respiration decreased KDR mRNA expression to 58% +/- 7.1% of control (P = 0.001) after 3 hours.	Oxygen	12-18	kinase insert domain receptor	Bos taurus	41-44
8634235-5	1996	The 113Cd NMR spectrum of [113Cd]HDH showed a resonance at 110 ppm, which indicates that the metal ion is bound to the protein by a combination of nitrogen and oxygen ligands.	Oxygen	160-166	histidinol dehydrogenase, chloroplastic	Brassica oleracea	33-36
15012237-1	1998	Cytochrome P450-dependent monooxygenases are a large group of heme-containing enzymes, most of which catalyze NADPH- and O2-dependent hydroxylation reactions.	Oxygen	121-123	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	11-15
9619879-4	1998	This difference in clonogenicity was apparent despite the fact that cells were plated in media containing sufficient serum and oxygen concentrations known to suppress apoptosis of exponentially growing Rat-1 fibroblasts with activated c-Myc.	Oxygen	127-133	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	235-240
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Oxygen	19-25	von Hippel-Lindau tumor suppressor	Homo sapiens	135-138
9628571-12	1998	CONCLUSIONS: With Cox regression, adjusting for age, forced expiratory volume in 1 second, partial pressure of carbon dioxide, partial pressure of oxygen, and diagnosis, lung transplantation showed a statistically significant effect on survival in selected patients with end-stage pulmonary disease.	Oxygen	147-153	cytochrome c oxidase subunit 8A	Homo sapiens	18-21
8639546-2	1996	The oxidized form (2), PT, which is present in solutions of PTH2, was shown to be the actual inhibitory species which irreversibly inactivates the protease; recycling of PTH2 by dissolved oxygen results in complete inhibition of the protease at substoichiometric amounts of compound.	Oxygen	188-194	parathyroid hormone 2	Homo sapiens	60-64
8639546-2	1996	The oxidized form (2), PT, which is present in solutions of PTH2, was shown to be the actual inhibitory species which irreversibly inactivates the protease; recycling of PTH2 by dissolved oxygen results in complete inhibition of the protease at substoichiometric amounts of compound.	Oxygen	188-194	parathyroid hormone 2	Homo sapiens	170-174
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	carbonic anhydrase 9	Homo sapiens	32-37
8902860-9	1996	Considering the general trend to noninvasive therapy in children and the more frequent adverse effects after epinephrine injection, such nebulized beta-2 agonists as terbutaline appear preferable for initial therapy of acute asthma if oxygen is supplemented to prevent possible hypoxemia.	Oxygen	235-241	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	147-153
9651558-1	1998	OBJECTIVES: Inhaled beta-2 agonists raise heart rate, systolic blood pressure and contractility, all of which cause an increase in oxygen consumption of the heart.	Oxygen	131-137	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	20-26
9595610-11	1998	A reliable and more accurate noninvasive method of recording oxygen saturation is thus needed, for use in both neonatal nurseries and in sleep studies, to aid in accurate clinical decision-making.	Oxygen	61-67	activation induced cytidine deaminase	Homo sapiens	155-158
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	carbonic anhydrase 9	Homo sapiens	39-60
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	aryl hydrocarbon receptor	Homo sapiens	266-269
8601644-9	1996	When AT2 cells in hypoxia are exposed to carbon monoxide, mRNA II is suppressed suggesting that a heme-binding protein (responsive to oxygen) may suppress mRNA II expression and may be responsible for the decrease in lung mRNA II seen after birth.	Oxygen	134-140	angiotensin II receptor, type 2	Rattus norvegicus	5-8
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	aryl hydrocarbon receptor	Homo sapiens	271-296
19299711-6	2009	CD4(+)CD25(+) regulatory T cells suppress N-alpha-syn microglial-induced reactive oxygen species and NF-kappaB activation by modulating redox-active enzymes, cell migration, phagocytosis, and bioenergetic protein expression and cell function.	Oxygen	82-88	interleukin 2 receptor subunit alpha	Homo sapiens	6-10
8613950-5	1996	V3 and P/O (ratio corresponds to the number of ADP molecules added in the medium per oxygen atom consumed during phosphorylation and represents the yield of ATP synthesis) were simultaneously decreased by CsA (1 microM) and restored by TMZ.	Oxygen	85-91	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	205-208
8626281-15	1996	During oxygen-limiting conditions the stationary-phase induction is partially dependent on ArcA.	Oxygen	7-13	arginine deiminase	Escherichia coli	91-95
8626294-0	1996	The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress.	Oxygen	61-67	arginine deiminase	Escherichia coli	69-73
9554930-1	1998	Cytochrome c oxidase, the terminal oxidase of mitochondria and some bacteria, catalyzes the four electron reduction of oxygen, and generates a proton electrochemical potential gradient (Delta microH).	Oxygen	119-125	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
9554930-2	1998	The recently determined structures of the bacterial and the bovine enzymes, together with studies of site directed mutants of a bacterial cytochrome c oxidase and a closely related ubiquinol oxidase, have greatly advanced our understanding of the mechanism by which oxygen reduction is coupled to the generation of Delta microH.	Oxygen	266-272	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	138-158
9575899-9	1998	Thus Hb-P11 delivered O2 twice as effectively as Hb-P35 to high-affinity sodium glucose and phosphate cotransporters in the late proximal tubule (S3 segment).	Oxygen	22-24	S100 calcium binding protein A10	Rattus norvegicus	8-11
9575899-10	1998	Hb-P11 may also have shunted O2 from the outer cortex to the outer medulla and facilitated O2 diffusion where PO2 was low.	Oxygen	29-31	S100 calcium binding protein A10	Rattus norvegicus	3-6
9575899-10	1998	Hb-P11 may also have shunted O2 from the outer cortex to the outer medulla and facilitated O2 diffusion where PO2 was low.	Oxygen	91-93	S100 calcium binding protein A10	Rattus norvegicus	3-6
8865684-5	1996	Plasma BNP in the first month had a significant negative correlation with anaerobic threshold (AT) and peak oxygen uptake (peak VO2), and the serial change in plasma BNP from the first to third month had a significant negative correlation with the serial change of AT (peak: r = -0.35, p &lt; 0.05) and peak VO2 (rest: r = -0.35, p &lt; 0.05; peak: r = -0.45, p &lt; 0.01).	Oxygen	108-114	natriuretic peptide B	Homo sapiens	7-10
19144536-7	2009	Based on the NPQ induction under 0% oxygen condition, we conclude that the water-water cycle is impaired in hma1, presumably due to the decreased level of Cu/Zn SOD in the mutant.	Oxygen	36-42	heavy metal atpase 1	Arabidopsis thaliana	108-112
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	86-88	lipoprotein(a)	Homo sapiens	0-36
9666356-3	1998	Ts65Dn mice consumed less (P &lt; 0.02) O2 per gram of fasted body weight.	Oxygen	40-42	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	0-6
9550543-11	1998	O2 uptake was significantly increased above control levels throughout the recovery period after exercise with the nonselective beta-adrenoceptor antagonist, beta1-adrenoceptor antagonist, and saline.	Oxygen	0-2	adrenoceptor beta 1	Homo sapiens	157-175
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	86-88	lipoprotein(a)	Homo sapiens	38-43
19335985-5	2009	RESULTS: Western blot analysis showed that both HIF-1 alpha and HSP70-2 proteins were strongly increased after HCC cells were exposed to hypoxic conditions (1% O2) for 6 h, and the expression level of HSP70-2 was increased in a time-dependent manner.	Oxygen	160-162	heat shock protein family A (Hsp70) member 2	Homo sapiens	64-71
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	94-96	lipoprotein(a)	Homo sapiens	0-36
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	94-96	lipoprotein(a)	Homo sapiens	38-43
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	94-96	lipoprotein(a)	Homo sapiens	0-36
8660295-1	1996	Lipid peroxidation of lipoprotein(a) [Lp(a)] by defined oxygen-centred free radicals (O2-/OH, O2-, O2-/HO2) produced by gamma radiolysis was compared with that of paired samples of low-density lipoprotein (LDL).	Oxygen	94-96	lipoprotein(a)	Homo sapiens	38-43
9510962-3	1998	Catalase activates the decomposition of H2O2 into water and oxygen, thus removing an initiator of free radical chain reactions leading to lipid peroxidation.	Oxygen	60-66	catalase	Bos taurus	0-8
19335985-5	2009	RESULTS: Western blot analysis showed that both HIF-1 alpha and HSP70-2 proteins were strongly increased after HCC cells were exposed to hypoxic conditions (1% O2) for 6 h, and the expression level of HSP70-2 was increased in a time-dependent manner.	Oxygen	160-162	heat shock protein family A (Hsp70) member 2	Homo sapiens	201-208
19164527-0	2009	A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump.	Oxygen	48-50	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	84-104
9546643-3	1998	This model was employed to examine whether carnitine palmitoyltransferase I (CPT-I) modulates high rates of beta-oxidation following oxygen deprivation.	Oxygen	133-139	carnitine palmitoyltransferase 1B	Rattus norvegicus	43-75
9546643-3	1998	This model was employed to examine whether carnitine palmitoyltransferase I (CPT-I) modulates high rates of beta-oxidation following oxygen deprivation.	Oxygen	133-139	carnitine palmitoyltransferase 1B	Rattus norvegicus	77-82
9388330-4	1996	The correlation between pHi and DO2 proves the oxygen supply dependency of VO2.	Oxygen	47-53	glucose-6-phosphate isomerase	Homo sapiens	24-27
19243301-4	2009	Disease-causing mutations targeting TD-NEM restrain VHL from mediating efficient oxygen-dependent degradation of HIFalpha by altering its subcellular dynamics.	Oxygen	81-87	von Hippel-Lindau tumor suppressor	Homo sapiens	52-55
9030290-3	1996	We also presented evidence which shows that expression of the gene for tyrosine hydroxylase, the rate-limiting enzyme in dopamine biosynthesis, is stimulated by reduced O2 tension in PC12 and type I carotid body cells.	Oxygen	169-171	tyrosine hydroxylase	Rattus norvegicus	71-91
8769729-0	1996	Endothelin-1 constricts fetoplacental microcirculation and decreases fetal O2 consumption in sheep.	Oxygen	75-77	EDN1	Ovis aries	0-12
8769729-9	1996	Endothelin-1 also decreases fetal oxygen consumption by an unknown mechanism.	Oxygen	34-40	EDN1	Ovis aries	0-12
9515734-3	1998	Both hypoxia (2% O2) and VEGF were found to increase tie-1 in a time-dependent manner.	Oxygen	17-19	tyrosine kinase with immunoglobulin like and EGF like domains 1	Bos taurus	53-58
18793248-10	2009	In one family, the proband had a new high oxygen-affinity haemoglobin variant (Haemoglobin Safi) resulting from the transversion C--&gt;A at codon 81 of the alpha2-globin gene.	Oxygen	42-48	hemoglobin subunit alpha 2	Homo sapiens	157-170
9438554-0	1998	Active oxygen-mediated chromosomal 1-2 Mbp giant DNA fragmentation into internucleosomal DNA fragmentation in apoptosis of glioma cells induced by glutamate.	Oxygen	7-13	myelin basic protein	Homo sapiens	39-42
9889870-2	1998	The International Society on Oxygen Transport to Tissue (ISOTT) was founded in April, 1973 by Drs.	Oxygen	29-35	sushi repeat containing protein X-linked	Homo sapiens	94-97
9889895-1	1998	Myoglobin (Mb), the muscular oxygen reservoir, was shown to possess peroxidative reactivity in presence of H2O2 leading to oxidation of isolated cellular proteins like myosin.	Oxygen	29-35	myosin, heavy chain 15	Gallus gallus	168-174
8554871-9	1995	Intercostal recession (relative risk RR 2.55; 95% CI 1.28, 5.08) and sternal retraction (RR 1.60; 95% CI 1.06, 2.42) predicted the need for supplemental oxygen with moderate accuracy.	Oxygen	153-159	ribonucleotide reductase catalytic subunit M1	Homo sapiens	89-93
8562921-5	1995	A mechanism likely to contribute to hypoxia-mediated generation of cytokines, such as interleukin 6, is activation of the transcription factor NF-IL-6, which occurs in oxygen deprivation.	Oxygen	168-174	CCAAT enhancer binding protein beta	Homo sapiens	143-150
9451527-0	1998	Effect of hyperbaric oxygen on intercellular adhesion molecule-1 (ICAM-1) expression in murine lung.	Oxygen	21-27	intercellular adhesion molecule 1	Mus musculus	31-64
19066835-3	2009	TfR mediates iron accumulation and reactive oxygen formation and thereby enhanced proliferation in clonal human glioma lines, as shown by the following experiments: (1) downregulating TfR expression reduced proliferation in vitro and in vivo; (2) forced TfR expression in low-grade glioma accelerated proliferation to the level of high-grade glioma; (3) iron and oxidant chelators attenuated tumor proliferation in vitro and tumor size in vivo.	Oxygen	44-50	transferrin receptor	Homo sapiens	0-3
9451527-0	1998	Effect of hyperbaric oxygen on intercellular adhesion molecule-1 (ICAM-1) expression in murine lung.	Oxygen	21-27	intercellular adhesion molecule 1	Mus musculus	66-72
9451527-3	1998	In the present study we have investigated the toxic effect of hyperbaric oxygen (HBO) expressed by the analysis of the intercellular adhesion molecule-1 (ICAM-1) on the pulmonary vascular endothelial cells and leukocyte function.	Oxygen	73-79	intercellular adhesion molecule 1	Mus musculus	119-152
9451527-3	1998	In the present study we have investigated the toxic effect of hyperbaric oxygen (HBO) expressed by the analysis of the intercellular adhesion molecule-1 (ICAM-1) on the pulmonary vascular endothelial cells and leukocyte function.	Oxygen	73-79	intercellular adhesion molecule 1	Mus musculus	154-160
9451527-7	1998	The expression of ICAM-1 was strongly enhanced immediately after HBO exposure and this enhancement lasted for 24 h. This suggests the importance of enhanced expression of adhesion molecules in the generation of pulmonary oxygen toxicity.	Oxygen	221-227	intercellular adhesion molecule 1	Mus musculus	18-24
7661383-2	1995	In the nonbrain infarct (non-BI) group (n = 13, mean age: sixty-two years), the regional CBF (rCBF) was decreased significantly with a rise in the mean arterial blood pressure (MABP) in the cerebral cortexes (r = -0.575) and the deep gray matter (r = -0.451), whereas the regional cerebral metabolic rate for oxygen (rCMRO2) remained unchanged.	Oxygen	309-315	CCAAT/enhancer binding protein zeta	Rattus norvegicus	89-92
7661383-2	1995	In the nonbrain infarct (non-BI) group (n = 13, mean age: sixty-two years), the regional CBF (rCBF) was decreased significantly with a rise in the mean arterial blood pressure (MABP) in the cerebral cortexes (r = -0.575) and the deep gray matter (r = -0.451), whereas the regional cerebral metabolic rate for oxygen (rCMRO2) remained unchanged.	Oxygen	309-315	CCAAT/enhancer binding protein zeta	Rattus norvegicus	94-98
7662713-0	1995	Pronounced activation of protein kinase C, ornithine decarboxylase and c-jun proto-oncogene by paraquat-generated active oxygen species in WI-38 human lung cells.	Oxygen	121-127	ornithine decarboxylase 1	Homo sapiens	43-66
7662713-11	1995	We therefore propose that superoxide anion (O2- and H2O2 generated by PQ could activate PKC and lead to induction of c-jun gene expression; on the other hand, O2- and .OH might trigger other kinase pathways to elevate ODC activity.	Oxygen	44-46	ornithine decarboxylase 1	Homo sapiens	218-221
7662713-11	1995	We therefore propose that superoxide anion (O2- and H2O2 generated by PQ could activate PKC and lead to induction of c-jun gene expression; on the other hand, O2- and .OH might trigger other kinase pathways to elevate ODC activity.	Oxygen	54-56	ornithine decarboxylase 1	Homo sapiens	218-221
18609042-0	2009	Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients.	Oxygen	59-65	natriuretic peptide B	Homo sapiens	23-26
7600839-5	1995	DATA SYNTHESIS: The oxygen status algorithm calculates the oxygen extraction tension and generates the oxygen graph as an aid in interpreting oxygen status of the patient.	Oxygen	20-26	activation induced cytidine deaminase	Homo sapiens	122-125
9430337-8	1997	Therefore, for the attachment of both cultured epithelial cells and fibroblasts to oxygen-containing surfaces in the presence of serum, there is a high requirement for serum vitronectin but a lesser requirement for fibronectin.	Oxygen	83-89	vitronectin	Bos taurus	174-185
19015195-1	2009	During brain activation, the decrease in the ratio between cerebral oxygen and carbohydrate uptake (6 O(2)/(glucose + (1)/(2) lactate); the oxygen-carbohydrate index, OCI) is attenuated by the non-selective beta-adrenergic receptor antagonist propranolol, whereas OCI remains unaffected by the beta(1)-adrenergic receptor antagonist metroprolol.	Oxygen	68-74	adrenoceptor beta 1	Homo sapiens	294-321
9367876-3	1997	As demonstrated by lucigenin-dependent chemiluminescence and superoxide dismutase-inhibitable cytochrome C reduction MCP-4 stimulated the production of reactive oxygen metabolites.	Oxygen	161-167	C-C motif chemokine ligand 13	Homo sapiens	117-122
7665405-14	1995	An uneven effect of O2 was observed on rCBF, most pronounced in brain stem regions, independent of the PaCO2.	Oxygen	20-22	CCAAT/enhancer binding protein zeta	Rattus norvegicus	39-43
7665413-11	1995	Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points.	Oxygen	9-11	superoxide dismutase 2	Homo sapiens	111-114
7665413-11	1995	Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points.	Oxygen	24-26	superoxide dismutase 2	Homo sapiens	111-114
9290157-5	1997	The extent of hCG reduction was dependent on the oxygen concentration.	Oxygen	49-55	chorionic gonadotropin subunit beta 5	Homo sapiens	14-17
19536501-5	2009	The cellular and molecular mechanisms of acute O(2)-sensing in the brain remain to be determined but they appear to involve O(2)-sensitive ion channels and heme oxygenase-2, which acts by a different mechanism than has been described for the carotid body.	Oxygen	47-51	heme oxygenase 2	Homo sapiens	156-172
9256439-1	1997	The crystal structures of cytochrome c oxidase from both bovine and Paracoccus denitrificans reveal two putative proton input channels that connect the heme-copper center, where dioxygen is reduced, to the internal aqueous phase.	Oxygen	178-186	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	26-46
7651752-5	1995	We report here that maternal hypoxia (11-13% O2) leads to 2-3-fold increases (p &lt; 0.01) in fetal adrenal TH, DBH, and NPY mRNA levels on the day before birth.	Oxygen	45-47	tyrosine hydroxylase	Rattus norvegicus	108-110
19536508-2	2009	Here we examined related NADPH oxidase homologues "novel oxidases "(NOX 1, 3&amp;4) and their possible involvement in O(2) sensing.	Oxygen	118-122	NADPH oxidase 1	Homo sapiens	68-73
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Oxygen	187-194	SH3 domain binding protein 1	Homo sapiens	37-41
7645982-3	1995	Human myelogenous leukemic cell lines (HL-60, ML-1) showed higher production of active oxygen(s) (detected by luminol chemiluminescence) and iodination capacity, than six other cultured cell lines.	Oxygen	87-93	interleukin 17F	Homo sapiens	46-50
7748039-4	1995	The authors previously have demonstrated that pretreatment with cytokines such as IL-1 or TNF can reduce the lethality of endotoxin (lipopolysaccharide), gram-negative sepsis, cancer cachexia, and oxygen toxicity.	Oxygen	197-203	interleukin 1 complex	Mus musculus	82-86
9211907-2	1997	When fully reduced QCR was allowed to react with dioxygen in the presence of cytochrome c plus cytochrome c oxidase, the oxidation of b-type hemes accompanied an initial lag, apparently low potential heme bL was oxidized first, followed by high potential heme bH.	Oxygen	49-57	LOC104968582	Bos taurus	77-89
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	aryl hydrocarbon receptor	Homo sapiens	99-124
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	aryl hydrocarbon receptor	Homo sapiens	126-129
19965111-5	2009	Recently, significant progress has been made for developing in vivo MRS imaging (MRSI) methods for noninvasively measuring and imaging the cerebral metabolic rates of oxygen (CMRO(2)) and ATP (CMR(ATP)) noninvasively.	Oxygen	167-173	ATPase phospholipid transporting 8A2	Homo sapiens	193-201
9247356-3	1997	The extensive oxidation of paired samples of Lp(a) and low-density lipoprotein (LDL) was achieved by O2.-/OH.	Oxygen	101-103	lipoprotein(a)	Homo sapiens	45-50
9224284-0	1997	Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide.	Oxygen	0-6	guanylate cyclase	Bos taurus	21-38
9224284-1	1997	PURPOSE: This study explores at which level of the guanylate cyclase pathway oxygen modulates retinal pericyte relaxation induced by nitric oxide (NO).	Oxygen	77-83	guanylate cyclase	Bos taurus	51-68
7758459-11	1995	Our results indicate that these sequences mediate the effects of the respective transactivator on the oxygen- and carbon-source-dependent transcription of the AAC2 gene.	Oxygen	102-108	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	159-163
7565112-8	1995	Therefore, expression of nuo is regulated by O2 and nitrate via ArcA, NarL, FNR and IHF at sites within the -277 region, and by other factors including C4 dicarboxylates at a site between -277 and -899.	Oxygen	45-47	arginine deiminase	Escherichia coli	64-68
23045014-2	2009	PAH is a non-heme-iron-dependent protein that normally catalyzes the C-oxidation of phenylalanine (Phe) to tyrosine (Tyr) in the presence of BH(4), utilizing molecular dioxygen as an additional substrate.	Oxygen	168-176	phenylalanine hydroxylase	Homo sapiens	0-3
19385226-6	2009	When the stable complex C1M is formed, the characteristic infrared vibration at 1,684 cm(-1) mainly caused by the ring"s vibration turns out to blueshift about 10 cm(-1), and the another characteristic vibration of 1,765 cm(-1) caused by vibration of bond C--O with oxygen atom acting on cations directly turns out to redshift by 112 cm(-1) for complex C1Ca+ and by 110 cm(-1) for C1Mg+.	Oxygen	266-272	angiotensin II receptor type 1	Homo sapiens	77-81
7744060-6	1995	267, 4524-4532] that Fe.ATP bound at the site for ATPB catalyzes the oxidative inactivation of carbamoyl-phosphate synthetase I in a model oxidative system consisting of Fe3+, ascorbate, and O2, and we detected ATP-promoted oxidative cleavage of the enzyme.	Oxygen	191-193	carbamoyl-phosphate synthase 1	Homo sapiens	95-127
9207771-13	1997	The results suggest that AmF and SnF2 enhance the oxygen-dependent antibacterial activity of neutrophils.	Oxygen	50-56	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	33-37
23120865-6	2009	Acute respiratory failure in patients with exacerbation of COPD demand controlled oxygen therapy and noninvasive ventilation or conventional mechanical ventilation.	Oxygen	82-88	COPD	Homo sapiens	59-63
9227519-3	1997	The activity of nitric oxide synthase (NOS) can be inhibited by hypoxia because molecular oxygen is a necessary substrate for the enzyme.	Oxygen	90-96	nitric oxide synthase, brain	Oryctolagus cuniculus	16-37
9219204-5	1997	Both the beta 1 and the combined beta 1, beta 2-adrenoreceptor antagonists reduced resting oxygen consumption to a similar extent (0.247 +/- 0.007 L.min-1 placebo, vs 0.218 +/- 0.007 L.min-1 beta 1-antagonism, vs 0.226 +/- 0.007 L.min-1 beta 1, beta 2-antagonism; P &lt; 0.05).	Oxygen	91-97	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	41-47
7779145-1	1995	This study describes the carioprotective effect of ceruloplasmin (CAS 9031-37-2) against oxygen free radical injury, as indicated by several biochemical indicators and some cardiodynamic variables.	Oxygen	89-95	ceruloplasmin	Rattus norvegicus	51-64
7705659-6	1995	In contrast, the WD motifs of Tup1 are not essential for repression of genes regulated by glucose and oxygen, but they are required for those regulated by cell type and DNA damage.	Oxygen	102-108	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	30-34
19347037-8	2009	The rapid clearance component (t(1/2) approximately 4-6 min) was abolished by the hypoxia-mimetic CoCl2 MG132 treatment and deletion of ODD domain, and reflects the oxygen/VHL-dependent degradation pathway.	Oxygen	165-171	von Hippel-Lindau tumor suppressor	Homo sapiens	172-175
7602313-4	1995	The effect was dose-dependent and peaked around an oxygen tension of 6%, where approximately 30% of glomus cells were GAP-43 positive.	Oxygen	51-57	growth associated protein 43	Rattus norvegicus	118-124
10072820-7	1997	Moreover, we found that the time to reach their steady state in mPAP and SvO2 were shortened when the patients were given oxygen breathing during exercise.	Oxygen	122-128	phospholipid phosphatase 1	Mus musculus	64-68
9110920-6	1997	Moreover, hyperoxia amplified the release of TNF-alpha by LPS-stimulated AM in an oxygen tension-dependent manner.	Oxygen	82-88	tumor necrosis factor	Macaca fascicularis	45-54
19347037-9	2009	The slow clearance component (t(1/2) approximately 200 min) is consistent with other unidentified non-oxygen/VHL-dependent degradation pathways.	Oxygen	102-108	von Hippel-Lindau tumor suppressor	Homo sapiens	109-112
7755283-8	1995	The observation that the induction by angiotensin II of both the AP1 DNA binding activity and DNA synthesis in quiescent C2C12 myoblasts is abolished by NAC strongly suggests a role for reactive oxygen intermediates (ROIs) in the intracellular transduction of angiotensin II signals for immediate early gene induction and for cell proliferation.	Oxygen	195-201	jun proto-oncogene	Mus musculus	65-68
19055396-5	2008	The CDA results also illustrated that there is a significant donation from the oxygen lone pair electrons to the boron vacant orbital in the adduct.	Oxygen	79-85	cytidine deaminase	Homo sapiens	4-7
7896790-5	1995	This activity exhibited an absolute requirement for the cytosolic activating factor p67phox but not for p47phox, suggesting that p67phox and p47phox have individual roles in controlling electron flow from NADPH to oxygen.	Oxygen	214-220	neutrophil cytosolic factor 2	Homo sapiens	84-91
7896790-5	1995	This activity exhibited an absolute requirement for the cytosolic activating factor p67phox but not for p47phox, suggesting that p67phox and p47phox have individual roles in controlling electron flow from NADPH to oxygen.	Oxygen	214-220	neutrophil cytosolic factor 2	Homo sapiens	129-136
7896790-6	1995	Here, we provide direct evidence that p67phox alone can facilitate electron flow from NADPH to the flavin center of NADPH oxidase in the absence of p47phox, resulting in the reduction of enzyme FAD, whereas the presence of p47phox is required in order for electron transfer to proceed beyond the flavin center to the heme in cytochrome b-245 and thence to oxygen.	Oxygen	356-362	neutrophil cytosolic factor 2	Homo sapiens	38-45
7862131-1	1995	Mutants of Saccharomyces cerevisiae lacking a functional SOD1 gene encoding Cu/Zn superoxide dismutase (SOD) are sensitive to atmospheric levels of oxygen and are auxotrophic for lysine and methionine when grown in air.	Oxygen	148-154	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	57-61
18634083-6	1997	At DO above 100%, the activities of GPX and GST decreased possibly as a result of inactivation by reactive oxygen radicals.The increase in dissolved oxygen concentration caused changes in energy metabolism.	Oxygen	107-113	peroxiredoxin 6 pseudogene 2	Mus musculus	36-39
9133430-5	1997	This apparent cell loss in E17 cultures could be largely prevented by combined treatment with bFGF and low oxygen (6% O(2)).	Oxygen	118-122	fibroblast growth factor 2	Rattus norvegicus	94-98
9222444-4	1997	The exogenous addition of superoxide dismutase, an oxygen radical scavenger, abolished the PA/plasmin activity enhanced by the HX/XOD system.	Oxygen	51-57	plasminogen	Homo sapiens	94-101
9126290-6	1997	Flt-1, Flk-1, and ACE-containing cells were detected in 3% O2-treated explants, whereas 20% O2 explants were virtually negative.	Oxygen	59-61	Fms related receptor tyrosine kinase 1	Rattus norvegicus	0-5
19055729-7	2008	In accordance with up-regulation of arcA, which may be caused by the lower oxygen solubility at 42 degrees C, the expressions of the TCA cycle-related genes and the respiratory chain gene cyoA were down-regulated.	Oxygen	75-81	arginine deiminase	Escherichia coli	36-40
9115640-4	1997	Mouse TPx had broad tissue distribution, but its expression was especially marked in cells that metabolize oxygen molecules at high levels such as erythroid cells, renal tubular cells, cardiac and skeletal muscle cells, and certain types of neurons.	Oxygen	107-113	peroxiredoxin 2	Mus musculus	6-9
7531495-1	1995	The ability of murine macrophage nitric oxide synthase (NOS) to utilize peroxides in place of O2 and NADPH was investigated using hydrogen peroxide (H2O2), tert-butylhydroperoxide, and cumene hydroperoxide with both L-arginine and NG-hydroxy-L-arginine (L-NHA) as substrates.	Oxygen	94-96	nitric oxide synthase 1, neuronal	Mus musculus	33-54
19088768-4	2008	CP was 123 (28) and 91 (26) W for boys and girls, respectively (p &lt; 0.02), which was equivalent to 75 (6) and 72 (10) % of peak oxygen uptake, respectively (p &gt; 0.47).	Oxygen	131-137	S100 calcium binding protein A8	Homo sapiens	0-2
7532422-6	1995	IAP levels increased with cancer stage, and were inversely related to the ability to produce active oxygen.	Oxygen	100-106	islet amyloid polypeptide	Homo sapiens	0-3
7779435-0	1995	Cytotoxic effect of tumour necrosis factor -alpha on sarcoma F cells at tumour relevant oxygen tensions.	Oxygen	88-94	phosphatidylglycerophosphate synthase 1	Mus musculus	53-62
7779435-3	1995	The median pO2 of the SaF is less than 1% oxygen with over 90% of values at or below 15 mmHg (&lt; 2% O2).	Oxygen	42-48	phosphatidylglycerophosphate synthase 1	Mus musculus	22-25
7779435-3	1995	The median pO2 of the SaF is less than 1% oxygen with over 90% of values at or below 15 mmHg (&lt; 2% O2).	Oxygen	12-14	phosphatidylglycerophosphate synthase 1	Mus musculus	22-25
7779435-4	1995	SaF cells primed in vitro for 24 h at tumour relevant oxygen tensions required at least four times more TNF to reduce cell number to 50% of controls following a 24 h incubation period in 21% oxygen.	Oxygen	54-60	phosphatidylglycerophosphate synthase 1	Mus musculus	0-3
9085569-7	1997	The increase in ADH activity associated with the spaceflight roots was realized by a 28% decrease in oxygen availability in a ground-based study; however, no reduction in redox potential was observed in measurements of the spaceflight bulk agar.	Oxygen	101-107	alcohol dehydrogenase 1	Arabidopsis thaliana	16-19
9027733-0	1997	Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia.	Oxygen	58-64	tyrosine hydroxylase	Rattus norvegicus	34-54
9027733-5	1997	Gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of dopamine, is stimulated by reduced O2 tension in both type I cells and PC12 cells.	Oxygen	129-131	tyrosine hydroxylase	Rattus norvegicus	19-39
9027733-5	1997	Gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of dopamine, is stimulated by reduced O2 tension in both type I cells and PC12 cells.	Oxygen	129-131	tyrosine hydroxylase	Rattus norvegicus	41-43
9027734-1	1997	Gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated by reductions in oxygen tension (hypoxia).	Oxygen	133-139	tyrosine hydroxylase	Rattus norvegicus	20-40
9027734-1	1997	Gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated by reductions in oxygen tension (hypoxia).	Oxygen	133-139	tyrosine hydroxylase	Rattus norvegicus	42-44
7779435-4	1995	SaF cells primed in vitro for 24 h at tumour relevant oxygen tensions required at least four times more TNF to reduce cell number to 50% of controls following a 24 h incubation period in 21% oxygen.	Oxygen	191-197	phosphatidylglycerophosphate synthase 1	Mus musculus	0-3
19088768-6	2008	End-exercise values for blood lactate concentration (B[La]) and maximal oxygen uptake were higher in the CP+10% trial (5.0 (2.4) mmol.L-1 and 2.15 (0.4) L.min-1, respectively) than in the CP trial, (B[La], 4.7 (2.1) mmol.L-1; maximal oxygen uptake, 2.05 (0.35) L.min-1; p &gt; 0.13).	Oxygen	234-240	S100 calcium binding protein A8	Homo sapiens	105-111
19088768-6	2008	End-exercise values for blood lactate concentration (B[La]) and maximal oxygen uptake were higher in the CP+10% trial (5.0 (2.4) mmol.L-1 and 2.15 (0.4) L.min-1, respectively) than in the CP trial, (B[La], 4.7 (2.1) mmol.L-1; maximal oxygen uptake, 2.05 (0.35) L.min-1; p &gt; 0.13).	Oxygen	234-240	S100 calcium binding protein A8	Homo sapiens	105-107
18838541-2	2008	A key regulator of HIF-1alpha is von Hippel-Lindau protein (pVHL), which mediates the oxygen-dependent, proteasomal degradation of HIF-1alpha in normoxia.	Oxygen	86-92	von Hippel-Lindau tumor suppressor	Homo sapiens	60-64
7574505-6	1995	E. coli, and other gram negative microorganisms, contain a periplasmic Cu, ZnSOD that may serve to protect against extracellular O2-.	Oxygen	129-131	Superoxide dismutase 1	Drosophila melanogaster	75-80
9009209-4	1997	A comparison is performed between the primary amino acid sequences of D1 and D2 and diiron-oxo enzymes with the function of oxygen activation.	Oxygen	124-130	leiomodin 1	Homo sapiens	70-79
18694997-4	2008	Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molecules) in response to lipopolysaccharide (LPS), as well as their stimulatory capacity for T-cell functions.	Oxygen	4-10	CD40 antigen	Mus musculus	106-110
9038903-0	1997	Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen.	Oxygen	77-83	transforming growth factor, beta 1	Mus musculus	34-42
9038903-3	1997	TGF-beta 1 immunostaining within cuboidal nonciliated bronchiolar epithelial cells was increased within 3 h of oxygen exposure and continued to increase for 48 h before decreasing to control levels by 72 h. A similar but less marked change that was morphologically consistent with alveolar type II cells was observed in granulated cells.	Oxygen	111-117	transforming growth factor, beta 1	Mus musculus	0-10
9038903-7	1997	Exposure to &gt; 95% oxygen resulted in cell type-specific posttranscriptional changes in TGF-beta isoforms in the lung.	Oxygen	21-27	transforming growth factor, beta 1	Mus musculus	90-98
8988993-2	1997	Transtracheal insufflation of oxygen (TRIO) maintains an immobilized lung, adequate oxygenation, and partial CO2 elimination but has never been used for VATS.	Oxygen	30-36	trio Rho guanine nucleotide exchange factor	Homo sapiens	38-42
7768031-10	1995	A significant decrease in oxygen delivery index was found in the REC group compared with the CON and HBO groups (P &lt; 0.05).	Oxygen	26-32	zinc finger DHHC-type palmitoyltransferase 2	Rattus norvegicus	65-68
7556120-7	1995	The LAT correlated with both the VO2 (r = 0.95, P &lt; 0.0001) and the work rate (r = 0.94, P &lt; 0.0001) at which the rate of tissue O2 desaturation accelerated.	Oxygen	34-36	linker for activation of T cells	Homo sapiens	4-7
18779824-2	2008	Acute peripheral administration of PP increases oxygen consumption in obese mice.	Oxygen	48-54	pancreatic polypeptide	Homo sapiens	35-37
7886644-12	1995	Averaged delta MBP at an SaO2 of 7% and 5% oxygen was 12.6 (5.7) and 13.4 (3.6) mm Hg, respectively, whereas the averaged delta MBP at the same delta SaO2 during apnoeic episodes was 38.4 (15.5) and 45.2 (20.5) mm Hg, respectively.	Oxygen	43-49	myelin basic protein	Homo sapiens	15-18
9032506-5	1997	In 70% of the patients, a transcutaneous oxygen saturation (Stc, O2) of less than 92% at night was found.	Oxygen	41-47	stanniocalcin 1	Homo sapiens	60-63
9034244-1	1997	Evolution of vertebrates from aquatic medium to the terrestrial atmosphere containing high concentration of environmental oxygen was accompanied by tissue-specific expression of the gene for L-gulonolactone oxidase (LGO).	Oxygen	122-128	gulonolactone (L-) oxidase	Rattus norvegicus	216-219
18786179-0	2008	VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes.	Oxygen	69-75	kinase insert domain protein receptor	Mus musculus	0-7
9034244-3	1997	In this paper we present data to indicate that emergence of LGO is apparently to provide the terrestrial vertebrates with adequate amount of ascorbic acid and thereby protect their tissues against oxygen toxicity.	Oxygen	197-203	gulonolactone (L-) oxidase	Rattus norvegicus	60-63
9034244-8	1997	The inverse relationship between LGO and SOD is also observed in rats during postnatal development, that is when the new born rats are exposed to high concentration of atmospheric oxygen.	Oxygen	180-186	gulonolactone (L-) oxidase	Rattus norvegicus	33-36
9034244-10	1997	Data presented in this paper also indicate an apparent tissue-specific correlation among LGO activity, P450 level and O2.- production during phylogenetic evolution.	Oxygen	118-120	gulonolactone (L-) oxidase	Rattus norvegicus	89-92
7846162-1	1994	Fructose-1,6-biphosphate aldolase (ALD) and enolase (ENO) from the glycolytic pathway and pyruvate decarboxylase (PDC) and alcohol dehydrogenase 2 (ADH2) from the ethanolic fermentative pathway, are enzymes previously identified as among those synthesized selectively in O2-deficient roots of maize (Zea mays L.).	Oxygen	271-273	enolase	Zea mays	44-51
7846162-1	1994	Fructose-1,6-biphosphate aldolase (ALD) and enolase (ENO) from the glycolytic pathway and pyruvate decarboxylase (PDC) and alcohol dehydrogenase 2 (ADH2) from the ethanolic fermentative pathway, are enzymes previously identified as among those synthesized selectively in O2-deficient roots of maize (Zea mays L.).	Oxygen	271-273	enolase	Zea mays	53-56
7846162-1	1994	Fructose-1,6-biphosphate aldolase (ALD) and enolase (ENO) from the glycolytic pathway and pyruvate decarboxylase (PDC) and alcohol dehydrogenase 2 (ADH2) from the ethanolic fermentative pathway, are enzymes previously identified as among those synthesized selectively in O2-deficient roots of maize (Zea mays L.).	Oxygen	271-273	alcohol dehydrogenase 2	Zea mays	123-146
7846162-1	1994	Fructose-1,6-biphosphate aldolase (ALD) and enolase (ENO) from the glycolytic pathway and pyruvate decarboxylase (PDC) and alcohol dehydrogenase 2 (ADH2) from the ethanolic fermentative pathway, are enzymes previously identified as among those synthesized selectively in O2-deficient roots of maize (Zea mays L.).	Oxygen	271-273	alcohol dehydrogenase 2	Zea mays	148-152
7846162-3	1994	In hypoxic seedlings with the roots in solution sparged with 5% (v/v) O2 (balance N2) and the shoots in the same gaseous atmosphere, mRNAs for Pdc1 and Adh2 in root tips both increased about 15-fold during the first 12 h, followed by a decline toward initial levels by 18 to 24h.	Oxygen	70-72	alcohol dehydrogenase 2	Zea mays	152-156
9165301-3	1997	The 1-2 Mbp giant DNA fragments were first observed 2 h after the T-24 cells were exposed to the active oxygen producing agents, or irradiated with x-ray.	Oxygen	104-110	myelin basic protein	Homo sapiens	8-11
18786179-0	2008	VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes.	Oxygen	69-75	placental growth factor	Mus musculus	103-107
18786179-5	2008	A significant increase in cell proliferation and survival to oxygen and glucose deprivation (OGD) was observed in PlGF-/- compared to PlGF+/+ astrocytes.	Oxygen	61-67	placental growth factor	Mus musculus	114-118
9198528-5	1997	The obtained data suggest that TRH affects the membrane structure and the morphology of erythrocytes, changes the functional activity of these cells and, thus, indirectly influences the rate of the oxygen supply to tissue.	Oxygen	198-204	thyrotropin releasing hormone	Rattus norvegicus	31-34
7696543-6	1994	When carried out under oxygen-enriched atmosphere, the reaction of HNE with dAdo yielded 1,N6-ethenodeoxyadenosine (1,N6-EdAdo) and 7-(1",2"-dihydroxyheptyl)-1,N6-EdA in 0.03% and 0.48% yield.	Oxygen	23-29	ectodysplasin A	Homo sapiens	121-124
18786179-5	2008	A significant increase in cell proliferation and survival to oxygen and glucose deprivation (OGD) was observed in PlGF-/- compared to PlGF+/+ astrocytes.	Oxygen	61-67	placental growth factor	Mus musculus	134-138
18809331-2	2008	It is widely accepted that HIF-1alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway.	Oxygen	105-111	von Hippel-Lindau tumor suppressor	Homo sapiens	168-172
7959800-2	1994	An enzyme electrode sensor measures the oxidation current of hydrogen peroxide formed by the stoichiometric conversion of glucose substrate and oxygen cofactor in an immobilized glucose oxidase layer.	Oxygen	144-150	Glucose dehydrogenase	Drosophila melanogaster	178-193
8981989-8	1997	It seems likely therefore, that PpsR responds to an integral signal (e.g., changes in redox potential) produced either by changes in oxygen tension or light intensity.	Oxygen	133-139	transcriptional regulator PpsR	Rhodobacter sphaeroides 2.4.1	32-36
9007663-11	1997	The demonstration of an increase in MVo2 despite no change or a decrease in cardiac work by coronary vasoconstriction with AVP at CCF, but not at CPP, suggests that cardiac O2 use is dependent more on maintenance of CF, despite increased resistance to perfusion, rather than on maintenance of perfusion pressure.	Oxygen	173-175	vasopressin-neurophysin 2-copeptin	Cavia porcellus	123-126
9046019-5	1997	It is proposed that the perferryl moiety P450 Fe3+.O2.- initiates lipid peroxidation by abstracting methylene hydrogen from polyunsaturated lipid to form lipid radical, which then combines with oxygen to produce the chain propagating peroxyl radical for subsequent formation of lipid peroxides.	Oxygen	51-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	41-45
9046019-5	1997	It is proposed that the perferryl moiety P450 Fe3+.O2.- initiates lipid peroxidation by abstracting methylene hydrogen from polyunsaturated lipid to form lipid radical, which then combines with oxygen to produce the chain propagating peroxyl radical for subsequent formation of lipid peroxides.	Oxygen	194-200	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	41-45
9046019-6	1997	Apparently, ascorbic acid prevents initiation of lipid peroxidation by interacting with P450 Fe3+.O2.-.	Oxygen	98-100	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	88-92
7930518-1	1994	We used the oxygen sensitivity of the histochemical reaction to detect glucose-6-phosphate dehydrogenase (G6PDH) activity based on neotetrazolium (NT) reduction to discriminate cancer cells from normal cells.	Oxygen	12-18	glucose-6-phosphate dehydrogenase	Rattus norvegicus	106-111
7930518-7	1994	G6PDH acted as described previously, showing distinct activity in cancer cells but strongly reduced activity in normal cells after incubation in oxygen, but this was not the case with LDH because formazan was also generated in normal tissue in oxygen.	Oxygen	145-151	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-5
7930518-7	1994	G6PDH acted as described previously, showing distinct activity in cancer cells but strongly reduced activity in normal cells after incubation in oxygen, but this was not the case with LDH because formazan was also generated in normal tissue in oxygen.	Oxygen	244-250	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-5
7930518-8	1994	It appeared that after 5 min of incubation at 37 degrees C the residual activity of G6PDH in an atmosphere of oxygen compared with nitrogen was 0% in normal liver tissue and 15% in normal colon epithelium, whereas in colon carcinoma and in colon carcinoma metastasis in liver it was 48% and 33%, respectively.	Oxygen	110-116	glucose-6-phosphate dehydrogenase	Rattus norvegicus	84-89
7930518-10	1994	These experiments clearly indicate that the oxygen sensitivity phenomenon is not solely an effect of competition for reducing equivalents between NT and oxygen via SOD, because NADPH generated by G6PDH and NADH generated by LDH have a similar redox potential.	Oxygen	44-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	196-201
7930518-10	1994	These experiments clearly indicate that the oxygen sensitivity phenomenon is not solely an effect of competition for reducing equivalents between NT and oxygen via SOD, because NADPH generated by G6PDH and NADH generated by LDH have a similar redox potential.	Oxygen	153-159	glucose-6-phosphate dehydrogenase	Rattus norvegicus	196-201
18926491-9	2008	This epistatic relationship between PPDK and O2 is further supported by quantitative and association genetics.	Oxygen	45-47	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	36-40
7932852-3	1994	One of the antioxidant enzymes that is protective against reactive oxygen-induced damage is manganese superoxide dismutase (MnSOD), which is located in the mitochondria of mammalian cells.	Oxygen	67-73	superoxide dismutase 2	Homo sapiens	92-122
7932852-3	1994	One of the antioxidant enzymes that is protective against reactive oxygen-induced damage is manganese superoxide dismutase (MnSOD), which is located in the mitochondria of mammalian cells.	Oxygen	67-73	superoxide dismutase 2	Homo sapiens	124-129
18600471-0	2008	Oxygen activation by cytochrome P450 monooxygenase.	Oxygen	0-6	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	32-36
7964404-6	1994	The myoglobin data demonstrate that the grey seals have the highest oxygen storage capacity of the three pinniped species, which correlates with their greater diving ability.	Oxygen	68-74	myoglobin	Rattus norvegicus	4-13
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	61-64	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91
8067420-2	1994	Because ratio fluorescence methodology can be applied to eliminate motion-induced errors, in the current study, we used a ratio fluorescence technique to evaluate myoglobin saturation in the perfused rat heart, since myoglobin is the major oxygen-dependent light absorbing species in this tissue.	Oxygen	240-246	myoglobin	Rattus norvegicus	217-226
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	61-64	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	183-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	183-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	185-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91
7798166-7	1994	Although xanthine dehydrogenase can produce greater amounts of superoxide anion than xanthine oxidase during xanthine-oxygen turnover, it seems to be physiologically insignificant because NAD inhibits almost completely the formation of superoxide anion.	Oxygen	118-124	xanthine dehydrogenase	Homo sapiens	9-31
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	185-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	222-228	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91
7522176-6	1994	Both, the oxygen burst resulting in the generation of superoxide anions and the degranulation of polymorphonuclear neutrophils accompanied by release of the lysosomal enzyme beta-glucuronidase, were significantly and dose dependently inhibited.	Oxygen	10-16	glucuronidase beta	Homo sapiens	174-192
8130204-6	1994	When supplemented with recombinant p67phox, the complex displayed considerable activity in a cell-free oxidase-activating system, and even without added p67phox, the complex could more than double O2- production in an oxidase-activating system supplemented with suboptimal amounts of cytosol.	Oxygen	197-199	neutrophil cytosolic factor 2	Homo sapiens	35-42
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Oxygen	222-228	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
8130204-6	1994	When supplemented with recombinant p67phox, the complex displayed considerable activity in a cell-free oxidase-activating system, and even without added p67phox, the complex could more than double O2- production in an oxidase-activating system supplemented with suboptimal amounts of cytosol.	Oxygen	197-199	neutrophil cytosolic factor 2	Homo sapiens	153-160
18600471-3	2008	Even though it carries out the opposite of the water splitting reaction, P450 may share similarities to PSII in proton delivery networks, oxygen and water access channels, and consecutive electron transfer processes.	Oxygen	138-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-77
18600471-4	2008	In this article, we review recent advances in understanding the molecular mechanisms by which P450 activates dioxygen.	Oxygen	109-117	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	94-98
19099877-6	2008	RESULTS: Under 100% O2 exposure, Prdx6-/- mice presented 24 h shorter survival time compared to wild type (WT) mice, on the contrary, Prdx6 gene over-expressed (Tg Prdx6) mice showed enhanced mice survival; meanwhile, the degree of AEC II cell injury had H2O2-dose dependent pattern with interactive relationship of Prdx6 protection.	Oxygen	20-22	peroxiredoxin 6	Mus musculus	33-38
18720322-0	2008	Dissociation between the effects of oxygen and pressure on matrix metalloproteinase-2, -7, and -9 expression in human airway epithelial cells.	Oxygen	36-42	matrix metallopeptidase 2	Homo sapiens	59-97
8306749-5	1994	The Cox model showed that the factors which independently reduced survival were lower CO transfer coefficient, smaller intrathoracic gas volume, more severe bronchial obstruction, the fact that oxygen administration did not increase PaO2 above 65 mm Hg, increasing age, and the presence of chest wall abnormalities.	Oxygen	194-200	cytochrome c oxidase subunit 8A	Homo sapiens	4-7
18252743-8	2008	Our results showed a positive effect of COMT val allele load upon the blood oxygen level-dependent response in LPFC, pre-SMA/ACC, and IPS during high g(f) versus low g(f) task performance in both spatial and verbal domains.	Oxygen	76-82	catechol-O-methyltransferase	Homo sapiens	40-44
8165058-12	1994	In GH-control rats, maximal oxygen uptake and succinate dehydrogenase were 69% and 25% greater, respectively, in trained compared with untrained rats (p &lt; 0.05).	Oxygen	28-34	gonadotropin releasing hormone receptor	Rattus norvegicus	3-5
7747938-13	1994	ArcA/B and FNR directly respond to O2, FhlA indirectly by decreased levels of formate in the presence of O2.	Oxygen	35-37	arginine deiminase	Escherichia coli	0-4
7747938-13	1994	ArcA/B and FNR directly respond to O2, FhlA indirectly by decreased levels of formate in the presence of O2.	Oxygen	105-107	arginine deiminase	Escherichia coli	0-4
18579531-12	2008	These data reinforce the role of ATF-1 as a hypoxia-responsive trans-activator and identifies a novel regulatory program that may modulate cellular responses to oxygen-deficit.	Oxygen	161-167	activating transcription factor 1	Mus musculus	33-38
7917182-2	1994	Ammonia formed by creatinine deiminase catalyzed hydrolysis of creatinine was converted to L-leucine by leucine dehydrogenase, and the oxidation of L-leucine by L-amino acid oxidase was detected with an oxygen electrode.	Oxygen	203-209	interleukin 4 induced 1	Homo sapiens	161-181
18599444-1	2008	Myoglobin is a globular protein involved in oxygen storage and transport.	Oxygen	44-50	myoglobin	Physeter catodon	0-9
8133213-5	1993	IGF-I caused a significant increase in the skin blood flow (P &lt; 0.05), utilization of oxygen (P &lt; 0.05), uptake of cysteine (P &lt; 0.05) and phenylalanine (P &lt; 0.001), and the rate of utilization of cysteine (P &lt; 0.05) for protein synthesis.	Oxygen	89-95	insulin-like growth factor I	Ovis aries	0-5
8155298-1	1993	By sequestering intracellular myoglobin of cardiac muscle cells in the nonfunctioning carboxymyoglobin form, carbon monoxide blocks myoglobin-facilitated diffusion of oxygen, as well as myoglobin-mediated oxidative phosphorylation.	Oxygen	167-173	myoglobin	Rattus norvegicus	30-39
8155298-1	1993	By sequestering intracellular myoglobin of cardiac muscle cells in the nonfunctioning carboxymyoglobin form, carbon monoxide blocks myoglobin-facilitated diffusion of oxygen, as well as myoglobin-mediated oxidative phosphorylation.	Oxygen	167-173	myoglobin	Rattus norvegicus	93-102
8155298-1	1993	By sequestering intracellular myoglobin of cardiac muscle cells in the nonfunctioning carboxymyoglobin form, carbon monoxide blocks myoglobin-facilitated diffusion of oxygen, as well as myoglobin-mediated oxidative phosphorylation.	Oxygen	167-173	myoglobin	Rattus norvegicus	93-102
8155298-6	1993	The effects observed were related to the fraction of intracellular myoglobin bound to CO. At physiological oxygen pressures no greater than 5 torr, after sequestration of approximately 50% of the myoglobin, steady-state oxygen uptake decreased significantly and was significantly less than the respiration of cell groups for which the fraction of carboxymyoglobin was 0% to 40%.	Oxygen	107-113	myoglobin	Rattus norvegicus	67-76
8155298-6	1993	The effects observed were related to the fraction of intracellular myoglobin bound to CO. At physiological oxygen pressures no greater than 5 torr, after sequestration of approximately 50% of the myoglobin, steady-state oxygen uptake decreased significantly and was significantly less than the respiration of cell groups for which the fraction of carboxymyoglobin was 0% to 40%.	Oxygen	220-226	myoglobin	Rattus norvegicus	67-76
8155298-6	1993	The effects observed were related to the fraction of intracellular myoglobin bound to CO. At physiological oxygen pressures no greater than 5 torr, after sequestration of approximately 50% of the myoglobin, steady-state oxygen uptake decreased significantly and was significantly less than the respiration of cell groups for which the fraction of carboxymyoglobin was 0% to 40%.	Oxygen	220-226	myoglobin	Rattus norvegicus	196-205
8403262-3	1993	To assess whether renal tubular myoglobin/iron loading, induced by a physiological mechanism (endocytosis), alters its susceptibility to O2 deprivation/reoxygenation- and H2O2-mediated injury, rats were infused with myoglobin or its vehicle (5% dextrose, control rats), and after 2 hours, proximal tubular segments (PTSs) were isolated for study.	Oxygen	137-139	myoglobin	Rattus norvegicus	32-41
8408312-0	1993	In vitro model of hypoxia: basic fibroblast growth factor can rescue cultured CNS neurons from oxygen-deprived cell death.	Oxygen	95-101	fibroblast growth factor 2	Rattus norvegicus	27-57
7505794-5	1993	G-CSF enhanced active oxygen generation of peritoneal macrophages and PMNs, significantly.	Oxygen	22-28	colony stimulating factor 3	Rattus norvegicus	0-5
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	48-50	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	63-67
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	48-50	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	229-233
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	170-172	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	63-67
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	170-172	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	229-233
8246886-7	1993	The sequence protected by O2, TGACTC, is also the binding site for GCN4.	Oxygen	26-28	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	67-71
8379942-13	1993	In addition to these delayed effects, we observed that EGF rapidly and transiently stimulated glucose synthesis from lactate, decreased the cytosolic redox state and increased oxygen consumption.	Oxygen	176-182	epidermal growth factor like 1	Rattus norvegicus	55-58
8396893-3	1993	Adrenodoxin reductase alone oxidized NADPH, reducing O2 to a superoxide radical at a very low rate.	Oxygen	53-55	ferredoxin reductase	Homo sapiens	0-21
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Oxygen	144-150	endothelin receptor type A	Homo sapiens	60-63
8342841-10	1993	CONCLUSIONS: Because the rCBF was less and the O2 extraction was similar, O2 consumption in the focal ischemic area of the brain during pentobarbital anesthesia must have been less than that during isoflurane anesthesia.	Oxygen	74-76	CCAAT/enhancer binding protein zeta	Rattus norvegicus	25-29
8344304-6	1993	This was done by studying the effect of the two acyl2GroPCho species on the kinetic parameters of some of the different steps of the P-450 cycle, namely substrate binding, oxygen binding and the rate of electron transfer.	Oxygen	172-178	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	133-138
8391485-4	1993	Comparison of these results with those obtained in an earlier investigation of the bovine cytochrome c oxidase [(1992) Biochemistry 31, 11853-11859], indicates differences between the two oxidases with respect to the role of protons in oxygen reduction and/or the mechanism of proton uptake from the medium.	Oxygen	236-242	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	90-110
8504641-4	1993	The variation in the MPST activity in mitochondria, regardless of the sex of the studied animals, is evidently under the influence of the thyroid gland activity, oxygen consumption and ambient temperature.	Oxygen	162-168	mercaptopyruvate sulfurtransferase	Canis lupus familiaris	21-25
8350650-0	1993	The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.	Oxygen	99-105	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	31-36
8350650-1	1993	A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator.	Oxygen	128-134	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	12-17
8350650-2	1993	Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type.	Oxygen	0-6	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	95-100
8350650-3	1993	In addition, the mean life span of rad-8 (but not wild type) was progressively shortened when animals incubated in increasing oxygen concentrations.	Oxygen	126-132	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	35-40
8463211-9	1993	O2 and NO rebinding to iron and cobalt derivatives of native, V68F, and V68I sperm whale myoglobin has been examined.	Oxygen	0-2	myoglobin	Physeter catodon	89-98
8477727-7	1993	In addition, they show that the AAC3 gene belongs to the family of yeast genes including TIF51B, COX5b, HEM13 and CYC7 that are negatively regulated by oxygen and heme.	Oxygen	152-158	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	114-118
8457553-5	1993	The Cd13-(Pi)2-MT form displays at least 24 113Cd signals between 240 and 520 ppm indicating (i) the absence of the original cluster structure of Cd7-MT, (ii) the participation of oxygen and/or nitrogen ligands besides thiolates in metal coordination, and (iii) the presence of more than one stable MT form in the sample.	Oxygen	180-186	alanyl aminopeptidase, membrane	Homo sapiens	4-8
8094958-1	1993	In these studies we show that stimulation of O2- generation by Tumor necrosis factor-alpha (TNF), or antibodies against the common beta 2 chain of leukocyte integrins (CD18), or LFA-1 (CD11a) displays a common and unique pattern of sensitivity or insensitivity to inhibitors of different signalling pathways.	Oxygen	45-47	integrin subunit alpha L	Homo sapiens	178-183
8094958-1	1993	In these studies we show that stimulation of O2- generation by Tumor necrosis factor-alpha (TNF), or antibodies against the common beta 2 chain of leukocyte integrins (CD18), or LFA-1 (CD11a) displays a common and unique pattern of sensitivity or insensitivity to inhibitors of different signalling pathways.	Oxygen	45-47	integrin subunit alpha L	Homo sapiens	185-190
8442664-4	1993	In different transgenic lines, overexpression of SOD by 32-42% above normal had either a minor and/or an insignificant effect on life span of the flies and their ability to withstand experimental oxidative stress, induced by paraquat intake and exposure to hyperoxia (100% oxygen).	Oxygen	273-279	Superoxide dismutase 1	Drosophila melanogaster	49-52
8457638-7	1993	Thus, singlet molecular oxygen (1O2) converts fibrin to a form that stimulates the activation of plasminogen (bound to oxidized fibrin) by pro-urokinase and that of pro-urokinase by plasmin.	Oxygen	6-30	plasminogen	Homo sapiens	97-104
8440412-5	1993	It is hypothesized that mitochondrial MnSOD, by scavenging oxygen radicals induced by cytokines, some cytotoxic drugs, and ionizing radiation, is protective and promotes the survival of cells from the lethal effects of these treatments.	Oxygen	59-65	superoxide dismutase 2	Homo sapiens	38-43
8380331-12	1993	These structural changes at the Fea3-CuB binuclear site controlled by the redox levels of the metal centers may provide a functional role(s) for the cytochrome c oxidase-catalyzed reactions, such as the reduction of dioxygen to water and the vectorial proton pumping across the mitochondrial inner membrane.	Oxygen	216-224	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	149-169
8314111-11	1993	With the Co(II)-FS, oxygen reactive species other than HO., might contribute to LADH inactivation.	Oxygen	20-26	dihydrolipoamide dehydrogenase	Sus scrofa	80-84
8272161-7	1993	A prolonged interaction of active oxygen species with chemical carcinogens (N-nitroso- or diazonium compounds, PAH) can exhibit a significant promoting effect on the development of intestinal type of gastric cancer from its precancerous conditions, above all after partial gastrectomy.	Oxygen	34-40	phenylalanine hydroxylase	Homo sapiens	111-114
8247759-2	1993	Electrostatic potential of a cyclic oxyphosphorane dianion 2, which is a model compound for an intermediate or a transition state for the hammerhead ribozyme reaction, indicates that Mg2+ coordinations at the regions between axial (bridging) and equatorial (phosphoryl) oxygens are most favorable.	Oxygen	270-277	mucin 7, secreted	Homo sapiens	183-186
1291034-0	1992	Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture.	Oxygen	82-88	fibroblast growth factor 2	Rattus norvegicus	0-30
1291034-1	1992	In the present study, we cultured rat CNS neurons and tested the neurotrophic support provided by basic fibroblast growth factor (bFGF) to prevent the oxygen-induced neuronal cell death.	Oxygen	151-157	fibroblast growth factor 2	Rattus norvegicus	98-128
1291034-1	1992	In the present study, we cultured rat CNS neurons and tested the neurotrophic support provided by basic fibroblast growth factor (bFGF) to prevent the oxygen-induced neuronal cell death.	Oxygen	151-157	fibroblast growth factor 2	Rattus norvegicus	130-134
1291034-4	1992	This oxygen-induced cell death of cultured basal forebrain neurons was reversed by the addition of bFGF at a concentration of 100 ng/ml.	Oxygen	5-11	fibroblast growth factor 2	Rattus norvegicus	99-103
1469715-1	1992	Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene.	Oxygen	13-19	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	67-71
1329770-5	1992	To determine the role of oxygen species in enzyme inhibition, GR was preincubated with either mannitol, diethylenetriaminepenta-acetic acid (DETAPAC), superoxide dismutase (SOD), catalase (CAT), or SOD and CAT prior to assays for enzyme inhibition by flavonoids.	Oxygen	25-31	glutathione-disulfide reductase	Homo sapiens	62-64
9353808-9	1997	Oxygen consumption rates in maximally activated intact control and obstructed preparations in other studies corresponded to a citrate synthase (rate-limiting enzyme) activity only 10% of the maximal enzyme activity found in the present study.	Oxygen	0-6	citrate synthase	Rattus norvegicus	126-142
8955074-1	1996	Neuronal nitric-oxide synthase (NOS-1) is a hemeprotein that generates NO and citrulline from L-arginine, O2, and NADPH.	Oxygen	106-108	nitric oxide synthase 1	Homo sapiens	32-37
8955074-6	1996	To examine how NO complex formation affects the O2 response of NOS-1, we measured rates of NO synthesis and NADPH oxidation versus O2 concentration in the presence and absence of L-arginine.	Oxygen	48-50	nitric oxide synthase 1	Homo sapiens	63-68
8955074-7	1996	In the absence of L-arginine, NOS-1 catalyzed simple O2 reduction, and its heme iron displayed a typical affinity for O2 (estimated KmO2 &lt;/= 40 microM, saturation at approximately 100 microM).	Oxygen	53-55	nitric oxide synthase 1	Homo sapiens	30-35
8955074-7	1996	In the absence of L-arginine, NOS-1 catalyzed simple O2 reduction, and its heme iron displayed a typical affinity for O2 (estimated KmO2 &lt;/= 40 microM, saturation at approximately 100 microM).	Oxygen	118-120	nitric oxide synthase 1	Homo sapiens	30-35
8955074-10	1996	We conclude that the O2 sensitivity of the ferrous-NO complex governs the O2 response of NOS-1 and thus its activity during the steady state.	Oxygen	21-23	nitric oxide synthase 1	Homo sapiens	89-94
8955074-10	1996	We conclude that the O2 sensitivity of the ferrous-NO complex governs the O2 response of NOS-1 and thus its activity during the steady state.	Oxygen	74-76	nitric oxide synthase 1	Homo sapiens	89-94
8955074-11	1996	This enables NOS-1 to couple its rate of NO synthesis to the O2 concentration throughout the physiologic range.	Oxygen	61-63	nitric oxide synthase 1	Homo sapiens	13-18
8973661-3	1996	By structure/activity relationship studies of naturally occurring and synthetic diterpene esters of the tigliane type (PKC activators) it is demonstrated that in addition to the oxygen at C20 it is the O-acyl function in position C13 which is critically essential for skin-irritant and tumor-promoting bioactivities rather than other oxygen atoms.	Oxygen	178-184	protein kinase C delta	Homo sapiens	119-122
8973661-3	1996	By structure/activity relationship studies of naturally occurring and synthetic diterpene esters of the tigliane type (PKC activators) it is demonstrated that in addition to the oxygen at C20 it is the O-acyl function in position C13 which is critically essential for skin-irritant and tumor-promoting bioactivities rather than other oxygen atoms.	Oxygen	334-340	protein kinase C delta	Homo sapiens	119-122
8955382-2	1996	The genes prrB and prrA encode a sensor kinase and a response regulator, respectively, of a two-component regulatory system that presumably is involved in transduction of the signal(s) that monitors alterations in oxygen levels.	Oxygen	214-220	ActS/PrrB/RegB family redox-sensitive histidine kinase	Rhodobacter sphaeroides 2.4.1	10-14
8945922-6	1996	In HUVEC, hypoxic conditions (1, 3, 5, and 14% O2) increased the phosphorylation of PECAM-1.	Oxygen	47-49	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-91
8945922-7	1996	The extent of phosphorylation of PECAM-1 was inversely related to the concentration of oxygen to which HUVEC were exposed.	Oxygen	87-93	platelet and endothelial cell adhesion molecule 1	Homo sapiens	33-40
8893848-3	1996	Replacement of the amide carbonyl oxygen by a sulfur atom had a detrimental effect on the CB1 affinity.	Oxygen	34-40	cannabinoid receptor 1 (brain)	Mus musculus	90-93
8918266-1	1996	By utilizing the oxygen-sensitive Escherichia coli Mn-superoxide dismutase (Mn-SOD) promoter, we have developed a vector system that expresses high levels of cloned foreign genes.	Oxygen	17-23	superoxide dismutase 2	Homo sapiens	76-82
8798765-12	1996	UBI1-UBI3 expression was repressed in the mutant under 100% O2, while expression of UBI4 was strongly induced.	Oxygen	60-62	ubiquitin-ribosomal 60S subunit protein L40A fusion protein	Saccharomyces cerevisiae S288C	0-4
8798765-12	1996	UBI1-UBI3 expression was repressed in the mutant under 100% O2, while expression of UBI4 was strongly induced.	Oxygen	60-62	ubiquitin-ribosomal 40S subunit protein S31 fusion protein	Saccharomyces cerevisiae S288C	5-9
8874387-4	1996	In a murine model of oxygen-induced ischemic retinopathy, there was intense staining for alpha v beta 3 in endothelial cells participating in neovascularization but no detectable staining in normal retinal blood vessels of adult mice.	Oxygen	21-27	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	97-103
8855365-8	1996	In our pharmacophore model for the 5-HT3 receptor antagonist, a basic center exists at the left side of the aromatic-carbonyl plane when viewing from the aromatic part with the carbonyl oxygen atom upwards, whereas the "handedness" is ambiguous in the previously proposed model.	Oxygen	186-192	5-hydroxytryptamine receptor 3A	Rattus norvegicus	35-49
8836047-6	1996	IRP inhibition was prevented by separate or simultaneous addition of superoxide dismutase and catalase, showing that both O2-.	Oxygen	122-124	Wnt family member 2	Homo sapiens	0-3
8836047-10	1996	Ferritin enhanced IRP inhibition, but this process involved tightly bound iron centers that shunted reducing equivalents from XO and returned them to oxygen, thus increasing the formation of O2-.	Oxygen	191-193	Wnt family member 2	Homo sapiens	18-21
8702521-6	1996	These results provide a mechanistic explanation for the observation that intact cells or mitochondria exhibit a reversible inhibition of respiration during prolonged exposure to [O2] &lt;25 mM, by demonstrating that the catalytic activity of cytochrome c oxidase function is similarly inhibited, possibly through an allosteric effect of molecular O2 on the enzyme.	Oxygen	347-349	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	242-262
8760150-0	1996	Effect of ACh and calmodulin inhibitor on O2 transfer from exocrine pancreatic microvessels of rats.	Oxygen	42-44	calmodulin 1	Rattus norvegicus	18-28
8760150-6	1996	These results indicate that 1) the ACh-induced elevation of O2 release from single microvessels is accomplished by increased O2 extraction instead of increased O2 inflow in the microvessels, and 2) the activity of a W-7-sensitive Ca2+ binding protein, most likely CaM, is responsible for half of the microvascular O2 transfer and of the pancreatic exocrine secretion.	Oxygen	60-62	calmodulin 1	Rattus norvegicus	264-267
8806915-4	1996	However, despite antibiotics, MAb 1B6 and rG-CSF both significantly increased the relative risk of death, independent of O2 concentration, during E. coli pneumonia (1.74 [symbol: see text] 1.20 and 2.39 [symbol: see text] 1.19, respectively, each P &lt; 0.01).	Oxygen	121-123	colony stimulating factor 3	Rattus norvegicus	42-48
8605177-1	1996	Human manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria against oxygen-mediated free radical damage.	Oxygen	108-114	superoxide dismutase 2	Homo sapiens	38-43
20733873-6	1992	The method is illustrated by an application to data obtained from a premixed methane-oxygen flame, and reasonable values of a, N, andD are obtained.	Oxygen	85-91	secretion associated Ras related GTPase 1B	Homo sapiens	130-134
1394426-1	1992	The 2.2 A resolution crystal structure of recombinant human manganese superoxide dismutase, a homotetrameric enzyme that protects mitochondria against oxygen-mediated free radical damage, has been determined.	Oxygen	151-157	superoxide dismutase 2	Homo sapiens	60-90
1437392-1	1992	Newborn rats prenatally treated with TRH or the combination of TRH + DEX have lower lung antioxidant enzyme activities at birth than control newborns but are able to induce an adaptive antioxidant enzyme response to hyperoxic exposure of similar or even greater magnitude compared to O2 control offspring.	Oxygen	284-286	thyrotropin releasing hormone	Rattus norvegicus	37-40
1437392-1	1992	Newborn rats prenatally treated with TRH or the combination of TRH + DEX have lower lung antioxidant enzyme activities at birth than control newborns but are able to induce an adaptive antioxidant enzyme response to hyperoxic exposure of similar or even greater magnitude compared to O2 control offspring.	Oxygen	284-286	thyrotropin releasing hormone	Rattus norvegicus	63-66
18599444-2	2008	No consensus yet exists on the atomic level mechanism by which oxygen and other small nonpolar ligands move between the myoglobin"s buried heme, which is the ligand binding site, and surrounding solvent.	Oxygen	63-69	myoglobin	Physeter catodon	120-129
1510191-2	1992	Inhalation of 50% oxygen in patients who were not in crisis produced a significant fall in RSCs and a lesser fall in ISCs.	Oxygen	18-24	NFS1 cysteine desulfurase	Homo sapiens	117-121
9026352-1	1996	Aerobic and anaerobic studies have demonstrated that uroporphyrin I-induced inactivation of delta-aminolevulinic acid dehydratase, porphobilinogenase, deaminase and uroporphyrinogen decarboxylase was dependent on oxygen and mediated by reactive oxygen species.	Oxygen	213-219	uroporphyrinogen decarboxylase	Homo sapiens	165-195
18559703-1	2008	BACKGROUND: The Study to Assess the Safety of Intramuscular Injection of Hepatocyte Growth Factor Plasmid to Improve Limb Perfusion in Patients With Critical Limb Ischemia (HGF-STAT trial) determined the effect of hepatocyte growth factor (HGF) plasmid on safety and limb tissue perfusion as measured by transcutaneous oxygen tension (TcPo(2)) in patients with critical limb ischemia (CLI).	Oxygen	319-325	hepatocyte growth factor	Homo sapiens	73-97
8676867-2	1996	In this study we have focussed our attention on the relationship between O2 and the cyPPDK1 gene, which encodes a cytoplasmic pyruvate orthophosphate dikinase (PPDK) isoform.	Oxygen	73-75	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	86-90
8676867-3	1996	The results of this study showed that PPDK activity is detectable in wild-type maize endosperms, while in o2 mutant endosperms, the levels of PPDK protein, mRNA and enzymatic activity are reduced, indicating that O2 is involved in the regulation of cyPPDK1 in this tissue.	Oxygen	213-215	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	38-42
8676867-3	1996	The results of this study showed that PPDK activity is detectable in wild-type maize endosperms, while in o2 mutant endosperms, the levels of PPDK protein, mRNA and enzymatic activity are reduced, indicating that O2 is involved in the regulation of cyPPDK1 in this tissue.	Oxygen	213-215	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	142-146
1379088-4	1992	GM-CSF-, IL-3-, and IL-5-treated Eos-HL-60 cells showed increased O2- production in response to phorbol esters (PMA), enhanced phagocytosis of Candida albicans, and release of the enzymes arylsulfatase, beta-glucuronidase and eosinophil peroxidase (EPO).	Oxygen	66-68	interleukin 5	Homo sapiens	20-24
18559703-1	2008	BACKGROUND: The Study to Assess the Safety of Intramuscular Injection of Hepatocyte Growth Factor Plasmid to Improve Limb Perfusion in Patients With Critical Limb Ischemia (HGF-STAT trial) determined the effect of hepatocyte growth factor (HGF) plasmid on safety and limb tissue perfusion as measured by transcutaneous oxygen tension (TcPo(2)) in patients with critical limb ischemia (CLI).	Oxygen	319-325	hepatocyte growth factor	Homo sapiens	173-176
8781036-2	1996	Lactate dehydrogenase produces the cofactor for glycolytic enzymes while glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produces the coenzymes for oxygen radical scavanging enzymes.	Oxygen	171-177	glucose-6-phosphate dehydrogenase	Rattus norvegicus	73-106
18433447-6	2008	Trypanosomes lacking frataxin also exhibited a low mitochondrial membrane potential and reduced oxygen consumption.	Oxygen	96-102	frataxin	Homo sapiens	21-29
8772656-7	1996	In contrast, FDG uptake in both cell lines increased significantly (23% and 38%, respectively) over normoxic (20% O2) conditions when cells were exposed to moderate hypoxia.	Oxygen	114-116	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	13-16
16668990-7	1992	Catalase was an effective inhibitor of the IF-induced changes in oxygen uptake and cytochrome c reducing activity.	Oxygen	65-71	catalase isozyme 1	Solanum lycopersicum	0-8
18516054-2	2008	One mechanism proposed to explain this oxygen-sensing-NO bioactivity linkage postulates an essential role for the conserved Cys93 residue of the hemoglobin beta-chain (betaCys93) and, specifically, for S-nitrosation of betaCys93 to form S-nitrosohemoglobin (SNO-Hb).	Oxygen	39-45	strawberry notch homolog 1	Homo sapiens	258-261
1569062-4	1992	However, anaerobic incubation of 0.1 microM calf thymus thioredoxin reductase and 20 microM GS-Se-SG resulted only in oxidation of a stoichiometric amount of NADPH; admission of oxygen started continuous NADPH oxidation.	Oxygen	178-184	thioredoxin	Bos taurus	56-67
1569062-6	1992	The rate of the oxygen-dependent reaction between calf thymus thioredoxin reductase and GS-Se-SG was increased 2-fold in the presence of 4 mM GSH, indicating that HSe- was the reactive intermediate.	Oxygen	16-22	thioredoxin	Bos taurus	62-73
8598569-6	1996	These results suggest that DEP taken up in the lung and located on alveolar spaces might cause cell injury by inhibiting the activity of catalase in epithelial lining fluid, enhancing the toxicity of H2O2 generated from cells in addition to that of O2- generated by the chemical reaction of DEP with oxygen.	Oxygen	300-306	catalase	Bos taurus	137-145
18593487-11	2008	CONCLUSIONS: Contrary to our initial hypothesis, during the first 5 min of CPR, 2 breaths/min resulted in significantly lower carotid blood flow and brain-tissue oxygen tension than did 10 breaths/min.	Oxygen	162-168	transforming growth factor beta regulator 4	Sus scrofa	75-81
8689949-1	1995	Flavin-containing monooxygenase-1 (FMO1) purified to homogeneity from pig liver microsomes catalyzes NADPH- and oxygen-dependent oxidation of salicylaldehyde to pyrocatechol and formate.	Oxygen	22-28	flavin containing dimethylaniline monoxygenase 1	Sus scrofa	35-39
8786668-0	1995	Induction of DNA polymerase beta and gamma in the lungs of age-related oxygen tolerant rats.	Oxygen	71-77	DNA polymerase beta	Rattus norvegicus	13-32
8786668-7	1995	DNA polymerase beta activities in 3W rats decreased up to 48 h with oxygen exposure, but recovered to pre-exposure levels by 72 h. Moreover, an induction of DNA polymerase gamma, which is related to mitochondrial DNA (mtDNA) replication and/or repair, was observed only in 3W rat lungs after 24 h of oxygen exposure.	Oxygen	68-74	DNA polymerase beta	Rattus norvegicus	0-19
8786668-7	1995	DNA polymerase beta activities in 3W rats decreased up to 48 h with oxygen exposure, but recovered to pre-exposure levels by 72 h. Moreover, an induction of DNA polymerase gamma, which is related to mitochondrial DNA (mtDNA) replication and/or repair, was observed only in 3W rat lungs after 24 h of oxygen exposure.	Oxygen	300-306	DNA polymerase beta	Rattus norvegicus	0-19
8786668-8	1995	From these results, we conclude that the induction of DNA polymerase beta and DNA polymerase gamma in lung tissue plays a key role in oxygen tolerance in very young rats.	Oxygen	134-140	DNA polymerase beta	Rattus norvegicus	54-73
8593266-2	1995	The DNA synthesis in human hair follicles and elongation of the hair shaft were measured subsequent to the follicle isolation and culture at 31 degrees C in 95% O2-5% CO2 for 72 h. Results showed that HGF/SF significantly increased 3H-thymidine (P &lt; 0.001) incorporation and hair follicle length (P &lt; 0.05).	Oxygen	161-163	hepatocyte growth factor	Homo sapiens	201-207
1314387-1	1992	Exposure to decreasing oxygen tensions progressively increased xanthine dehydrogenase (XD) and xanthine oxidase (XO) activities over 48 hr in cultured pulmonary artery endothelial cells (EC) without altering XD/XO ratios.	Oxygen	23-29	xanthine dehydrogenase	Homo sapiens	63-85
1314387-1	1992	Exposure to decreasing oxygen tensions progressively increased xanthine dehydrogenase (XD) and xanthine oxidase (XO) activities over 48 hr in cultured pulmonary artery endothelial cells (EC) without altering XD/XO ratios.	Oxygen	23-29	xanthine dehydrogenase	Homo sapiens	87-89
1314387-2	1992	Increases in XD and XO activity in EC induced by hypoxia were associated upon reoxygenation with increased (P less than 0.05) extracellular superoxide anion (O2-.)	Oxygen	158-160	xanthine dehydrogenase	Homo sapiens	13-15
1372530-9	1992	MGMT activity was also increased by treatment of the cells with H2O2, in accordance with the involvement of activated oxygen species in the induction of MGMT.	Oxygen	118-124	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	0-4
1372530-9	1992	MGMT activity was also increased by treatment of the cells with H2O2, in accordance with the involvement of activated oxygen species in the induction of MGMT.	Oxygen	118-124	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	153-157
7551375-6	1995	Paralleling these changes the Na,K-ATPase activity decreased by approximately 41% in AT2 cells isolated from rats after 64 h of breathing 100% O2 and increased by approximately 25% after the rats recovered in room air for 7 d. These results suggest that alveolar epithelial Na,K-ATPase may contribute in the recovery from the hyperoxic lung injury by participating in the clearance of lung edema.	Oxygen	143-145	angiotensin II receptor, type 2	Rattus norvegicus	85-88
18779124-1	2008	MnSOD, which is an important oxygen free radical scavenger in organisms, has an effect to resist oxidative stress and tumor.	Oxygen	29-35	superoxide dismutase 2	Homo sapiens	0-5
18402772-1	2008	When Escherichia coli cells were grown with limited levels of oxygen, the glucose-induced transcription of ptsG was decreased whereas deletion of the arcA gene partially restored it, which was consistent with the previous report that the ArcA protein represses ptsG transcription.	Oxygen	62-68	arginine deiminase	Escherichia coli	150-154
8542070-0	1995	Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons.	Oxygen	33-39	epidermal growth factor like 1	Rattus norvegicus	0-23
8542070-2	1995	We found that EGF prevented the death of rat cerebral cortical neurons cultured in a 50% oxygen atmosphere.	Oxygen	89-95	epidermal growth factor like 1	Rattus norvegicus	14-17
8542070-4	1995	EGF prevented the oxygen-induced death of the cultured cortical neurons in a dose-dependent manner.	Oxygen	18-24	epidermal growth factor like 1	Rattus norvegicus	0-3
18402772-1	2008	When Escherichia coli cells were grown with limited levels of oxygen, the glucose-induced transcription of ptsG was decreased whereas deletion of the arcA gene partially restored it, which was consistent with the previous report that the ArcA protein represses ptsG transcription.	Oxygen	62-68	arginine deiminase	Escherichia coli	238-242
7594973-7	1995	and O2.- produced is reflected in the Asc.- production.	Oxygen	4-6	steroid sulfatase	Mus musculus	38-41
18198211-2	2008	Neuroglobin (Ngb), a recently discovered vertebrate globin expressed predominantly in the brain, shows increased expression in neurons in response to oxygen deprivation and protects neurons from ischemic and hypoxic death.	Oxygen	150-156	neuroglobin	Mus musculus	0-11
8575238-6	1995	The mechanisms involved in this reduced concentration of bFGF in wounded muscles included oxygen radical activation, inflammatory response and reduced secretion of endogenous bFGF.	Oxygen	90-96	fibroblast growth factor 2	Rattus norvegicus	57-61
18198211-2	2008	Neuroglobin (Ngb), a recently discovered vertebrate globin expressed predominantly in the brain, shows increased expression in neurons in response to oxygen deprivation and protects neurons from ischemic and hypoxic death.	Oxygen	150-156	neuroglobin	Mus musculus	13-16
7646492-4	1995	The expression of beta-actin remained unchanged under arterial and venous O2.	Oxygen	74-76	actin, beta	Rattus norvegicus	18-28
19099788-0	2008	[Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen].	Oxygen	108-114	plasminogen activator, urokinase	Rattus norvegicus	12-16
7582866-9	1995	The results suggested that an interaction between active oxygen and PMN elastase may increase the clinical severity of this disease.	Oxygen	57-63	elastase, neutrophil expressed	Homo sapiens	68-80
19099788-4	2008	In this study, the authors established an animal model of CLD induced by inhaling high concentration oxygen (hyperoxia) to investigate the changes and functions of urokinase-plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in CLD.	Oxygen	101-107	plasminogen activator, urokinase	Rattus norvegicus	164-195
18452327-5	2008	In contrast, when the COH oxygen is H-bonded, the nuC=O frequencies upshift to 1785-1800 cm(-1).	Oxygen	26-32	nucleobindin 1	Homo sapiens	50-53
7665405-4	1995	O2 breathing caused CBF to fall by 30% in group 1, whereas CBF rose linearly with the PaCO2 increase and pH decline in group 2.	Oxygen	0-2	CCAAT/enhancer binding protein zeta	Rattus norvegicus	20-23
18239076-0	2008	Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.	Oxygen	108-114	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	30-58
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Oxygen	202-208	glutamic--pyruvic transaminase	Homo sapiens	105-134
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Oxygen	202-208	glutamic--pyruvic transaminase	Homo sapiens	136-139
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Oxygen	272-278	glutamic--pyruvic transaminase	Homo sapiens	136-139
7768808-2	1995	In anaerobic conditions, catalase activity was detected in stationary-phase cultures, indicating that not only oxygen exposure but also starvation may affect the production of this antioxidant enzyme.	Oxygen	111-117	catalase	Bos taurus	25-33
7649895-4	1995	Because P-450aldo and P-450scc are mitochondrial enzymes that depend on the same NADPH-specific electron transport proteins, we hypothesized that O2 sensitivity would be independent of energy production and expressed in isolated mitochondria.	Oxygen	146-148	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	22-30
18239076-4	2008	Additionally, PGC-1alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake.	Oxygen	87-93	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-24
18239076-4	2008	Additionally, PGC-1alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake.	Oxygen	182-188	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-24
7783618-5	1995	The fnr and arcA gene products are required for this oxygen control and each acts to repress sdhC-lacZ expression.	Oxygen	53-59	arginine deiminase	Escherichia coli	12-16
18239076-6	2008	Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake.	Oxygen	191-197	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	50-60
18438213-6	2008	Oxygen consumption was significantly lower carrying the double-strap golf bag (L x min(-1), p = 0.0004; ml x kg(-1) x min(-1), p &lt; 0.0003), as were heart rate (p = 0.0013) and rate of perceived exertion (p &lt; 0.005) During the double strap trial, the perceived comfort was higher (p &lt; 0.005).	Oxygen	0-6	serine/threonine kinase receptor associated protein	Homo sapiens	63-68
7837273-2	1995	These 12 new structures, plus those of wild-type myoglobin, have been used to interpret the effects of mutations at position 68 and the effects of cobalt substitution on the kinetics of O2, CO, and NO binding.	Oxygen	186-188	myoglobin	Physeter catodon	49-58
18438213-6	2008	Oxygen consumption was significantly lower carrying the double-strap golf bag (L x min(-1), p = 0.0004; ml x kg(-1) x min(-1), p &lt; 0.0003), as were heart rate (p = 0.0013) and rate of perceived exertion (p &lt; 0.005) During the double strap trial, the perceived comfort was higher (p &lt; 0.005).	Oxygen	0-6	serine/threonine kinase receptor associated protein	Homo sapiens	239-244
18366153-2	2008	These active site models have different O2 binding modes to the diiron center, such as the mu-eta2,eta2, trans-mu-1,2 and cis-mu-1,2 conformations.	Oxygen	40-42	DNA polymerase iota	Homo sapiens	94-98
7819218-8	1995	The higher affinity of DANSGTP indicates additional participation in binding of the C-6 oxygen on the guanine.	Oxygen	88-94	complement C6	Homo sapiens	84-87
18366153-2	2008	These active site models have different O2 binding modes to the diiron center, such as the mu-eta2,eta2, trans-mu-1,2 and cis-mu-1,2 conformations.	Oxygen	40-42	DNA polymerase iota	Homo sapiens	99-103
7734059-2	1995	During the oxygen reductase activity of P450, molecular oxygen is reduced to superoxide anion radicals (O2-.)	Oxygen	11-17	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-44
18252725-1	2008	Nuclear respiratory factor-1 (NRF-1) is integral to the transcriptional regulation of mitochondrial biogenesis, but its control over various respiratory genes overlaps other regulatory elements including those involved in O(2) sensing.	Oxygen	222-226	nuclear respiratory factor 1	Homo sapiens	0-28
7734059-2	1995	During the oxygen reductase activity of P450, molecular oxygen is reduced to superoxide anion radicals (O2-.)	Oxygen	104-106	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-44
7734059-10	1995	Moreover, description of the molecular mechanisms of xenobiotic and oxygen reduction reactions by P450 is limited by the lack of knowledge of the three-dimensional (3D) structure of the mammalian P450 proteins.	Oxygen	68-74	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-102
7734059-10	1995	Moreover, description of the molecular mechanisms of xenobiotic and oxygen reduction reactions by P450 is limited by the lack of knowledge of the three-dimensional (3D) structure of the mammalian P450 proteins.	Oxygen	68-74	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	196-200
18252725-1	2008	Nuclear respiratory factor-1 (NRF-1) is integral to the transcriptional regulation of mitochondrial biogenesis, but its control over various respiratory genes overlaps other regulatory elements including those involved in O(2) sensing.	Oxygen	222-226	nuclear respiratory factor 1	Homo sapiens	30-35
18252725-5	2008	We postulated that NRF-1 suppression either specifically decreases the expression of one or more SDH subunits and increases succinate availability to regulate HIF-1 prolyl hydroxylases, or stimulates mitochondrial reactive oxygen production, which interferes with HIF-1alpha degradation.	Oxygen	223-229	nuclear respiratory factor 1	Homo sapiens	19-24
10155169-7	1995	Further, a low gastric mucosal pHi on admission to the ICU appears to be predictive of mortality and pHi-guided resuscitation may improve outcome in a subpopulation of patients admitted to the ICU with normal pHi, perhaps by preventing splanchnic ischemia and the development of a systemic oxygen deficit.	Oxygen	290-296	glucose-6-phosphate isomerase	Homo sapiens	31-34
18318467-1	2008	Anionic O2 derivatives of methyl 3-deoxy-3-(4-methylbenzamido)-1-thio-beta-D-galactopyranoside have been synthesized as inhibitors against galectin-3.	Oxygen	8-10	galectin 3	Homo sapiens	139-149
10155169-7	1995	Further, a low gastric mucosal pHi on admission to the ICU appears to be predictive of mortality and pHi-guided resuscitation may improve outcome in a subpopulation of patients admitted to the ICU with normal pHi, perhaps by preventing splanchnic ischemia and the development of a systemic oxygen deficit.	Oxygen	290-296	glucose-6-phosphate isomerase	Homo sapiens	101-104
10155169-7	1995	Further, a low gastric mucosal pHi on admission to the ICU appears to be predictive of mortality and pHi-guided resuscitation may improve outcome in a subpopulation of patients admitted to the ICU with normal pHi, perhaps by preventing splanchnic ischemia and the development of a systemic oxygen deficit.	Oxygen	290-296	glucose-6-phosphate isomerase	Homo sapiens	101-104
18323779-4	2008	In addition, we show that overexpression of Siah2 or oxygen and glucose deprivation (OGD) promotes Siah2-mediated ubiquitination and proteolysis of AKAP121.	Oxygen	53-59	siah E3 ubiquitin protein ligase 2	Homo sapiens	99-104
7535686-4	1994	Neutrophil numbers in bronchoalveolar lavage fluid peaked after 60 hr of exposure to s 95% oxygen; this was associated with a marked upregulation of mRNA for the adhesion molecules P-selectin and E-selectin but not VCAM-1.	Oxygen	91-97	vascular cell adhesion molecule 1	Rattus norvegicus	215-221
7896566-1	1994	Xanthine oxidoreductase is an enzyme which has the unusual property that it can exist in a dehydrogenase form which uses NAD+ and an oxidase form which uses oxygen as electron acceptor.	Oxygen	157-163	xanthine dehydrogenase	Homo sapiens	0-23
18336467-0	2008	p21(Cip1) expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture.	Oxygen	45-51	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	4-8
7918491-10	1994	The residue corresponding to Cys449 in A. vinlandii lipoamide dehydrogenase (Val447) is about 9 A from the carbonyl oxygen at C(2) in the pyrimidine ring of FAD.	Oxygen	116-122	dihydrolipoamide dehydrogenase	Sus scrofa	52-75
1588940-8	1992	The involvement of active oxygen in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, iodide, mannitol, formate and catalase (the inhibition was complete in the last case).	Oxygen	26-32	catalase	Bos taurus	154-162
18336467-3	2008	In the present study, we hypothesized that 20% O2 in culture represents a sufficient stimulus to cause increased expression of two key negative regulators of the cell-cycle Cip/Kip family of cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), in MPCs.	Oxygen	47-49	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	231-235
7526150-1	1994	Previous studies have shown that exposure of phenobarbital-pretreated rats to halothane in 10% O2 causes centrilobular necrosis, induces expression of the 72-kDa heat shock protein (HSP72), and produces several trifluoroacetylated adducts.	Oxygen	95-97	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	182-187
7526150-9	1994	In contrast, HSP72 was induced only in the rats pretreated with phenobarbital and exposed to 1% halothane in 10% O2.	Oxygen	113-115	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	13-18
1554389-9	1992	Catalase partially blocked the AHH inhibitory activity of MCM suggesting that activated oxygen intermediates are partially involved in the AHH inhibitory activity of the MCM.	Oxygen	88-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	31-34
18336467-8	2008	Furthermore, 20% O2 caused an increase in p21(Cip1) mRNA stability and p53 transcription factor activity.	Oxygen	17-19	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	46-50
1554389-9	1992	Catalase partially blocked the AHH inhibitory activity of MCM suggesting that activated oxygen intermediates are partially involved in the AHH inhibitory activity of the MCM.	Oxygen	88-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-142
18276645-2	2008	In fission yeast, the ortholog of mammalian sterol regulatory element binding protein (SREBP), called Sre1, activates low-oxygen gene expression and is essential for anaerobic growth.	Oxygen	122-128	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	44-85
7809574-7	1994	From these results, it is concluded that: (1) cellular proliferation in the lung is most active during the first 2 weeks after birth as supported by the increases in DNA polymerase alpha activity and DNA content, and (2) anticipating the oxygen enriched atmosphere after birth, the level of DNA polymerase beta, involved in the DNA repair system, is already elevated during the prenatal period and remains constant throughout the postnatal period.	Oxygen	238-244	DNA polymerase beta	Rattus norvegicus	291-310
1643246-7	1992	The data show that in the presence of FMO1 micromolar amounts of either of these ring-opened metabolites establish a futile cycle catalyzing the oxidation of GSH to GSSG by NADPH and oxygen.	Oxygen	183-189	flavin containing dimethylaniline monoxygenase 1	Sus scrofa	38-42
8092315-8	1994	The scaling factor (determined by allometric analysis) relating maximal O2 uptake (VO2max) to muscle CSA for the whole sample population was 1.04 +/- 0.12 (SE), but the scaling factor relating WRpeak to muscle CSA was significantly greater (1.37 +/- 0.12).	Oxygen	72-74	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	101-104
18276645-2	2008	In fission yeast, the ortholog of mammalian sterol regulatory element binding protein (SREBP), called Sre1, activates low-oxygen gene expression and is essential for anaerobic growth.	Oxygen	122-128	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	87-92
18276645-9	2008	Together, these results describe a new mechanism for oxygen-dependent control of gene expression and provide an example of negative regulation of protein expression by an SREBP homolog.	Oxygen	53-59	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	171-176
18364393-1	2008	Recombinant HIV-Tat (Tat) induces extensive apoptosis in peripheral blood mononuclear cells (PBMCs) cultured in typical CO2 incubators, which are equilibrated with air (21% O2).	Oxygen	121-123	tyrosine aminotransferase	Homo sapiens	16-19
7836167-8	1994	In conclusion, glucose uptake during 40 min of exercise at 72% peak pulmonary oxygen consumption was inversely related to the total muscle GLUT-4 protein level.	Oxygen	78-84	solute carrier family 2 member 4	Homo sapiens	139-145
1311273-3	1992	Subsequent removal of HCO3-/CO2 (HEPES/O2 substitution) from the serosal perfusate caused a further decrease of pHi.	Oxygen	29-31	glucose-6-phosphate isomerase	Homo sapiens	112-115
17950634-0	2008	The high oxygen-affinity Hemoglobin Johnstown [(beta 109(G11) Val--&gt;Leu] in a German kindred with an elevated erythrocyte hemoglobin content: potential interaction with HFE mutations.	Oxygen	9-15	homeostatic iron regulator	Homo sapiens	172-175
1346877-7	1992	CLD (defined as requirement for supplemental oxygen at 28 days after birth) developed in significantly fewer TRH-treated infants (18% vs 44% of controls, p less than 0.01).	Oxygen	45-51	thyrotropin releasing hormone	Homo sapiens	109-112
1346877-9	1992	There were significantly fewer adverse outcomes, defined as death or continuing oxygen requirement, in the TRH group than in the steroid-alone group both at 28 days and when infants reached 36 weeks" postconceptional age.	Oxygen	80-86	thyrotropin releasing hormone	Homo sapiens	107-110
8078883-1	1994	A point mutation in the mtDNA-encoded ATP6 gene (T--&gt;G at nt 8993) associated with Leigh syndrome in two pedigrees was found to decrease ADP-stimulated (state III) respiration and the ratio of ADP molecules phosphorylated to oxygen atoms reduced (ADP/O ratio) but did not affect 2,4-dinitrophenol (DNP)-uncoupled respiration, suggesting a defective mitochondrial H(+)-translocating ATP synthase.	Oxygen	228-234	mitochondrially encoded ATP synthase 6	Homo sapiens	38-42
18206868-3	2008	Here we determined the role of PECAM-1 in the postnatal development of retinal vasculature and retinal neovascularization during oxygen-induced ischemic retinopathy (OIR) using PECAM-1-deficient (PECAM-1-/-) mice.	Oxygen	129-135	platelet/endothelial cell adhesion molecule 1	Mus musculus	31-38
8049810-12	1994	Moreover, a rise in gastric pHi in response to increases in systemic O2 transport may be a better indicator of regional hypoxia in septic patients than related increases in systemic VO2.	Oxygen	69-71	glucose-6-phosphate isomerase	Homo sapiens	28-31
1311570-0	1992	Acceleration of the oxygen reaction in CuA-deficient Nitrosomonas europaea cytochrome c oxidase as revealed by the flow-flash measurement.	Oxygen	20-26	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	75-95
1311570-1	1992	The oxygen reaction of Nitrosomonas europaea cytochrome c oxidase containing either 2Cu or 1Cu per two heme a molecules was investigated by the flow-flash technique at 20 degrees C. The reaction profiles of the bacterial enzyme were essentially the same as those of bovine heart cytochrome c oxidase, although the rate of the primary oxygen compound formation was much slower.	Oxygen	4-10	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	45-65
1311570-1	1992	The oxygen reaction of Nitrosomonas europaea cytochrome c oxidase containing either 2Cu or 1Cu per two heme a molecules was investigated by the flow-flash technique at 20 degrees C. The reaction profiles of the bacterial enzyme were essentially the same as those of bovine heart cytochrome c oxidase, although the rate of the primary oxygen compound formation was much slower.	Oxygen	4-10	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	279-299
1311570-1	1992	The oxygen reaction of Nitrosomonas europaea cytochrome c oxidase containing either 2Cu or 1Cu per two heme a molecules was investigated by the flow-flash technique at 20 degrees C. The reaction profiles of the bacterial enzyme were essentially the same as those of bovine heart cytochrome c oxidase, although the rate of the primary oxygen compound formation was much slower.	Oxygen	334-340	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	45-65
1316173-8	1992	Although it is poorly reactive with O2, it can transfer electrons back to cytochrome c and TMPD.	Oxygen	36-38	LOC104968582	Bos taurus	74-86
7804128-2	1994	At physiological pH values, these oligopeptides greatly suppressed the generation of .OH from the reaction of Cu(en)2 (en: ethylenediamine) with hydrogen peroxide (H2O2), although these oligopeptides did not scavenge O2-.	Oxygen	166-168	engrailed homeobox 2	Homo sapiens	110-117
8027554-7	1994	The allelic phenotype of Fc gamma RIIa strongly influences the Fc gamma receptor engagement by ligand, and Fc gamma RIIa homozygous donors differ by more than threefold in the quantitative production of reactive oxygen intermediates (ROI) (p &lt; 0.01).	Oxygen	212-218	Fc gamma receptor IIa	Homo sapiens	25-38
8027554-7	1994	The allelic phenotype of Fc gamma RIIa strongly influences the Fc gamma receptor engagement by ligand, and Fc gamma RIIa homozygous donors differ by more than threefold in the quantitative production of reactive oxygen intermediates (ROI) (p &lt; 0.01).	Oxygen	212-218	Fc gamma receptor IIa	Homo sapiens	107-120
1346170-11	1992	pHi-guided resuscitation may help improve outcome in such patients by preventing splanchnic organ hypoxia and the development of a systemic oxygen deficit.	Oxygen	140-146	glucose-6-phosphate isomerase	Homo sapiens	0-3
18082129-0	2008	Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages.	Oxygen	107-113	uncoupling protein 2	Homo sapiens	0-20
1309354-13	1992	We propose that the sensitivity of 18-hydroxylase to oxygen accounts for the dissociation of renin and aldosterone during hypoxia in vivo.	Oxygen	53-59	renin	Bos taurus	93-98
8041793-0	1994	The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae.	Oxygen	57-63	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	4-8
18082129-7	2008	These findings extend our understanding of the homeostatic function of UCP2 in regulating mitochondrial reactive oxygen production by identifying a feedback loop that senses mitochondrial reactive oxygen production and increases inner mitochondrial membrane UCP2 abundance and activity.	Oxygen	113-119	uncoupling protein 2	Homo sapiens	71-75
17991881-9	2008	Finally, ventilation of healthy neonatal sheep with 100% O2 for 24 hours leads to increased PDE5 protein expression in the resistance pulmonary arteries and increased PDE5 activity in whole lung extracts.	Oxygen	57-59	PDE5A	Ovis aries	92-96
1822535-15	1991	But, they are consistent with the idea that the adenosine that is important is not released from muscle fibres, but synthesized by 5"-nucleotidase localized to the blood vessels; its activity may decrease proximally along the vascular tree and may vary from one vessel to another depending on the local O2 tension.	Oxygen	303-305	5' nucleotidase, ecto	Rattus norvegicus	131-146
17991881-9	2008	Finally, ventilation of healthy neonatal sheep with 100% O2 for 24 hours leads to increased PDE5 protein expression in the resistance pulmonary arteries and increased PDE5 activity in whole lung extracts.	Oxygen	57-59	PDE5A	Ovis aries	167-171
18219391-3	2008	Here we demonstrate that SOD1 is not just a catabolic enzyme, but can also directly regulate NADPH oxidase-dependent (Nox-dependent) O(2)(*-) production by binding Rac1 and inhibiting its GTPase activity.	Oxygen	133-137	Rac family small GTPase 1	Mus musculus	164-168
1766349-3	1991	Oxygen uptake (VO2) responses were significantly more pronounced in direct relationship to the bench height: B-12 greater than B-10 greater than B-8 greater than B-6 (P less than 0.05).	Oxygen	0-6	NADH:ubiquinone oxidoreductase subunit A2	Homo sapiens	145-148
18399238-0	2008	Interpretation of the multiple vanadium-oxygen bonds in the central VO(eta2-O2)+ group.	Oxygen	40-46	DNA polymerase iota	Homo sapiens	71-78
1924356-1	1991	As we have briefly described elsewhere, cytochrome P-450 catalyzes the oxidative deformylation of cyclohexane carboxaldehyde to yield cyclohexene and formic acid in a reaction believed to involve a peroxyhemiacetal-like adduct formed between the substrate and molecular oxygen-derived hydrogen peroxide.	Oxygen	270-276	cytochrome P-450	Oryctolagus cuniculus	40-56
17880903-7	2008	As such, early beta 2 animals showed a decrease in cerebral O2 delivery of approximately 20% (P = .06) and conversely an increase in cerebral glucose delivery of 1.4- and 1.3-fold at late beta 1 (P &lt; .05) and early beta 2 (P = .08), respectively.	Oxygen	60-62	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-21
1924315-1	1991	Copper, zinc superoxide dismutase (SOD1 gene product) (superoxide:superoxide oxidoreductase, EC 1.15.1.1) is a copper-containing enzyme that functions to prevent oxygen toxicity.	Oxygen	162-168	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	35-39
18349550-1	2008	ArcA is a global regulator that switches on the expression of fermentation genes and represses the aerobic pathways when Escherichia coli enters low oxygen growth conditions.	Oxygen	149-155	arginine deiminase	Escherichia coli	0-4
1885542-1	1991	The Escherichia coli arcA gene product regulates chromosomal gene expression in response to deprivation of oxygen (Arc function; Arc stands for aerobic respiration control) and is required for expression of the F plasmid DNA transfer (tra) genes (Sfr function; Sfr stands for sex factor regulation).	Oxygen	107-113	arginine deiminase	Escherichia coli	21-25
19009468-5	2008	No significantly different peak values for power output and stroke volume were found for the two systems, but the modified ES-LCE elicited significantly higher peak values for oxygen uptake (+22%), carbon dioxide production (+51%), pulmonary ventilation (+37%), cardiac output (+32%), heart rate (+19%), and blood lactate concentration (+50%).	Oxygen	176-182	ELOVL fatty acid elongase 6	Homo sapiens	126-129
1910074-6	1991	CCa2+ showed a significant positive correlation with oxygen tension (PO2) (r = 0.71, P less than 0.002).	Oxygen	53-59	crystallin beta B2	Homo sapiens	0-4
18383352-0	2008	Decreasing the expression of LFA-1 and ICAM-1 as the major mechanism for the protective effect of hyperbaric oxygen on ischemia-reperfusion injury.	Oxygen	109-115	integrin subunit alpha L	Homo sapiens	29-34
1860156-8	1991	In aqueous buffer, pH 2.5, and in the presence of 1 mM AA, 50 microM nitrite was consumed with a t1/2 of 50 min only if molecular oxygen had first been removed from the system.	Oxygen	130-136	interleukin 1 receptor like 1	Homo sapiens	97-107
1855986-14	1991	These results suggest that IF1 interferes not only with S. aureus stimulation of PMNs via complement receptors but also with oxygen-dependent bactericidal activity.	Oxygen	125-131	ATP synthase inhibitory factor subunit 1	Homo sapiens	27-30
18025794-6	2008	The cord plasma KL-6 levels in patients with atypical BPD were significantly higher in infants with moderate or severe BPD than in infants with mild BPD (median = 88.3 vs. 41.5 U/ml, p = 0.041) and were found to be significantly correlated with the duration of oxygen therapy (r = 0.502, p = 0.024).	Oxygen	261-267	mucin 1, cell surface associated	Homo sapiens	16-20
18216461-14	2008	Serial change and severity of PAP elevations have a significant association with oxygen requirements and functional status, but not transplant outcomes.	Oxygen	81-87	phospholipid phosphatase 1	Mus musculus	30-33
18220085-6	2008	MEASUREMENTS AND RESULTS: Markers of hypoxia (lowest oxygen saturation level and %T&lt;90), correlated significantly with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (Pearson"s r = -0.31 to -0.38, P &lt;0.003), while apnea hypopnea index, body mass index, blood pressure, fasting glucose, triglyceride, and cholesterol levels did not.	Oxygen	53-59	glutamic--pyruvic transaminase	Homo sapiens	159-183
18159247-8	2007	Moreover, studies of murine hypoxia (8% oxygen over 6 h) showed TLR2 and TLR 6 induction in mucosal organs in vivo.	Oxygen	40-46	toll-like receptor 2	Mus musculus	64-68
18044974-0	2007	Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila.	Oxygen	36-42	Guanylyl cyclase at 88E	Drosophila melanogaster	80-87
18044974-4	2007	The results reported here show that Gyc-88E from Drosophila is a hemoprotein that binds oxygen, as well as NO and CO.	Oxygen	88-94	Guanylyl cyclase at 88E	Drosophila melanogaster	36-43
18044974-6	2007	Gyc-88E is active as a homodimer (5600 +/- 243 nmol min(-1) mg(-1)) and is inhibited by O2, CO, and NO (3.2-, 2.9-, and 2-fold, respectively).	Oxygen	88-90	Guanylyl cyclase at 88E	Drosophila melanogaster	0-7
18044974-9	2007	The biochemical properties of Gyc-88E are unique for guanylate cyclases and suggest a possible function as an oxygen sensor.	Oxygen	110-116	Guanylyl cyclase at 88E	Drosophila melanogaster	30-37
17609976-8	2007	The secretion of IL-6, leptin, MIF and VEGF from the adipocytes was also stimulated by exposure to 1% O(2).	Oxygen	102-106	macrophage migration inhibitory factor	Homo sapiens	31-34
17704187-4	2007	We discovered that MV of 2- to 4-day-old mice with 40% O(2) for 8 h, compared with unventilated control pups, reduced lung expression of genes that regulate lung septation and angiogenesis (VEGF-A and its receptor, VEGF-R2; PDGF-A; and tenascin-C).	Oxygen	55-59	kinase insert domain protein receptor	Mus musculus	215-222
17704187-4	2007	We discovered that MV of 2- to 4-day-old mice with 40% O(2) for 8 h, compared with unventilated control pups, reduced lung expression of genes that regulate lung septation and angiogenesis (VEGF-A and its receptor, VEGF-R2; PDGF-A; and tenascin-C).	Oxygen	55-59	platelet derived growth factor, alpha	Mus musculus	224-230
17704187-4	2007	We discovered that MV of 2- to 4-day-old mice with 40% O(2) for 8 h, compared with unventilated control pups, reduced lung expression of genes that regulate lung septation and angiogenesis (VEGF-A and its receptor, VEGF-R2; PDGF-A; and tenascin-C).	Oxygen	55-59	tenascin C	Mus musculus	236-246
17704187-6	2007	MV of 4- to 6-day-old mice with 40% O(2) for 24 h reduced lung protein abundance of VEGF-A, VEGF-R2, PDGF-A, and tenascin-C and resulted in lung structural abnormalities consistent with evolving CLD.	Oxygen	36-40	kinase insert domain protein receptor	Mus musculus	92-99
17704187-6	2007	MV of 4- to 6-day-old mice with 40% O(2) for 24 h reduced lung protein abundance of VEGF-A, VEGF-R2, PDGF-A, and tenascin-C and resulted in lung structural abnormalities consistent with evolving CLD.	Oxygen	36-40	platelet derived growth factor, alpha	Mus musculus	101-107
17704187-6	2007	MV of 4- to 6-day-old mice with 40% O(2) for 24 h reduced lung protein abundance of VEGF-A, VEGF-R2, PDGF-A, and tenascin-C and resulted in lung structural abnormalities consistent with evolving CLD.	Oxygen	36-40	tenascin C	Mus musculus	113-123
17895552-0	2007	Prognostic value of arterial/alveolar oxygen tension ratio (a/APO2) in acute pulmonary embolism.	Oxygen	38-44	TNF receptor superfamily member 10a	Homo sapiens	62-66
17845607-12	2007	IFN-tau secretion was not affected by biopsies, but culture under atmospheric O(2) resulted in significantly increased IFN-tau concentration in medium droplets (12274.0 +/- 2825.9 pM vs 5046.5 +/- 2562.2 pM; p &lt; 0.05).	Oxygen	78-82	interferon tau-2	Bos taurus	119-126
19194525-0	2007	Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells.	Oxygen	20-26	bone morphogenetic protein 4	Homo sapiens	34-38
8048556-3	1994	The changes in [Ca2+]m were compared with alpha-ketoglutarate dehydrogenase (alpha-KGDH) flux, measured as O2 consumption (nmol.min-1.mg protein-1) from 185 microM alpha-ketoglutarate (alpha-KG).	Oxygen	107-109	oxoglutarate dehydrogenase	Rattus norvegicus	77-87
17397983-3	2007	Its activation depends on the interaction with cytosolic regulatory proteins (p67-phox, p47-phox, p40-phox and Rac) leading to an electron transfer from NADPH to molecular oxygen and to the release of superoxide anions.	Oxygen	172-178	neutrophil cytosolic factor 2	Homo sapiens	78-86
7960943-2	1994	It was therefore hypothesized that the expression of ecto-5"-nucleotidase in fibroblasts might be controlled by oxygen tension.	Oxygen	112-118	5' nucleotidase, ecto	Rattus norvegicus	53-73
7960943-9	1994	The intralobular gradient of ecto-5"-nucleotidase in perisinusoidal cells and the effect thereon of anaemia suggest that the expression of the ecto-5"-nucleotidase might be directly or indirectly controlled by local oxygen tension.	Oxygen	216-222	5' nucleotidase, ecto	Rattus norvegicus	29-49
7960943-9	1994	The intralobular gradient of ecto-5"-nucleotidase in perisinusoidal cells and the effect thereon of anaemia suggest that the expression of the ecto-5"-nucleotidase might be directly or indirectly controlled by local oxygen tension.	Oxygen	216-222	5' nucleotidase, ecto	Rattus norvegicus	143-163
8023930-6	1994	The reduction in endoneurial oxygen tension regressed with glycosylated hemoglobin (Y = 53.8-2.7X, where Y = %reduction in endoneurial oxygen tension and X = HbA1; r = 0.87; P = &lt; 0.001).	Oxygen	29-35	hemoglobin alpha, adult chain 1	Rattus norvegicus	158-162
17882713-4	2007	C57BL/C6 mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and returned to room air thereafter.	Oxygen	34-40	CDK2 (cyclin-dependent kinase 2)-associated protein 1	Mus musculus	70-73
8032656-13	1994	Following preincubation for 30 min in low O2 containing media, basal pseudosubstrate phosphorylation increased whilst the fold stimulation by TPA and ET-1 decreased.	Oxygen	42-44	EDN1	Ovis aries	150-154
17443661-5	2007	The PAH enzyme converts phenylalanine to tyrosine in the presence of molecular oxygen and catalytic amounts of tetrahydrobiopterin (BH4), its nonprotein cofactor.	Oxygen	79-85	phenylalanine hydroxylase	Homo sapiens	4-7
8032656-15	1994	In cells preincubated in low O2 containing medium, ET-1-stimulated [3H]-inositol phosphate accumulation was reduced by approximately 30-40%.	Oxygen	29-31	EDN1	Ovis aries	51-55
7930803-6	1994	Our studies show that HSF-1 is phosphorylated following heat shock (43 degrees C for 1 h), hypoxia (5 h exposure to 0.02% oxygen), 8% ethanol (1 h exposure at 37 degrees C), or 200 microM sodium arsenite (1 h exposure at 37 degrees C).	Oxygen	122-128	heat shock transcription factor 1	Homo sapiens	22-27
17675521-9	2007	Taken together, PF4-stimulated immediate monocyte functions (oxygen radical formation) are regulated by p38 MAPK, Syk, and PI3K, whereas delayed functions (survival and cytokine expression) are controlled by Erk and JNK.	Oxygen	61-67	platelet factor 4	Homo sapiens	16-19
8169328-1	1994	The effects of temperature on development and life span were examined in a radiation- and oxygen-hypersensitive mutant (rad-8) of the nematode Caenorhabditis elegans.	Oxygen	90-96	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	120-125
8169328-5	1994	It was also dependent upon oxygen concentration, because the mean life spans of rad-8 and wild type were experimentally identical when reared at 16 degrees C in the presence of 5% rather than atmospheric oxygen.	Oxygen	27-33	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	80-85
8169328-6	1994	The rad-8 mutant represents an interesting paradox, as its life span can either be shortened or lengthened relative to the wild type, depending on temperature and oxygen concentration.	Oxygen	163-169	Reticulon-4-interacting protein 1, mitochondrial	Caenorhabditis elegans	4-9
8155661-4	1994	The adduct with the unsubstituted hydrazine was instead assigned an o-quinone hydrazone form, stabilized by an internal hydrogen bond between the amino group and the ortho carbonyl oxygen, a larger electron delocalization, and formation of a hydrogen bond at the C-6 ionized hydroxyl.	Oxygen	181-187	complement C6	Homo sapiens	263-266
17725851-0	2007	Effects of low oxygen levels on the expression and function of transporter OCTN2 in BeWo cells.	Oxygen	15-21	solute carrier family 22 member 5	Homo sapiens	75-80
7908289-1	1994	Reduced oxygen tension (hypoxia) induces a 3-fold increase in stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line.	Oxygen	8-14	tyrosine hydroxylase	Rattus norvegicus	84-104
7908289-1	1994	Reduced oxygen tension (hypoxia) induces a 3-fold increase in stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line.	Oxygen	8-14	tyrosine hydroxylase	Rattus norvegicus	106-108
7908289-7	1994	The binding of the protein to TH mRNA was increased when cytoplasmic proteins were extracted from PC12 cells exposed to hypoxia (5% O2) for 24 h. Electrophoresis of the UV cross-linked RNA-protein complex on SDS-polyacrylamide gel electrophoresis revealed a complex of 74 kDa.	Oxygen	132-134	tyrosine hydroxylase	Rattus norvegicus	30-32
17388354-0	2007	Kinetics and rate constants of the reaction CH2OH+O2--&gt;CH2O+HO2 in the temperature range of 236-600 K. The kinetics and absolute rate constants of the gas-phase reaction of the hydroxymethyl radical (CH2OH) with molecular oxygen have been studied using laser photolysis/near-IR absorption spectroscopy.	Oxygen	225-231	heme oxygenase 2	Homo sapiens	63-66
8135806-1	1994	Immunocytochemical studies have revealed that one of the major heat shock proteins, HSP72, is induced in livers of rats that have been pretreated with phenobarbital and then administered halothane in a hypoxic gas mixture of 10% oxygen.	Oxygen	229-235	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	84-89
8145237-11	1994	The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.	Oxygen	267-273	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	165-171
1920799-3	1991	The oxygen uptake value at the points of 0.5 mmol.l-1 and 1.0 mmol.l-1 increase in the lactic acid values when compared with the starting values were designated as 0.5 LAT and 1.0 LAT.	Oxygen	4-10	linker for activation of T cells	Homo sapiens	168-171
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Oxygen	0-6	neuroglobin	Mus musculus	93-96
1920799-3	1991	The oxygen uptake value at the points of 0.5 mmol.l-1 and 1.0 mmol.l-1 increase in the lactic acid values when compared with the starting values were designated as 0.5 LAT and 1.0 LAT.	Oxygen	4-10	linker for activation of T cells	Homo sapiens	180-183
8138752-10	1994	These observations are consistent with the hypothesis that both IGF-I and IGF-II are chronically regulated by oxygen and nutrition in utero and mediate part of the influence of placental supply of substrate over fetal growth.	Oxygen	110-116	insulin-like growth factor I	Ovis aries	64-69
8138752-10	1994	These observations are consistent with the hypothesis that both IGF-I and IGF-II are chronically regulated by oxygen and nutrition in utero and mediate part of the influence of placental supply of substrate over fetal growth.	Oxygen	110-116	insulin-like growth factor II	Ovis aries	74-80
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Oxygen	0-6	neuroglobin	Mus musculus	118-121
1957353-3	1991	This article reviews the properties of two transcriptional regulators, ArcA and FNR, which control the expression of networks of genes in response to oxygen limitation.	Oxygen	150-156	arginine deiminase	Escherichia coli	71-75
17559924-2	2007	At the blastocyst stage, ATP is produced by glycolysis and oxidative phosphorylation, processes that require uptake of oxygen and glucose, which is regulated by the expression of GLUT1 and G6PD.	Oxygen	119-125	solute carrier family 2 member 1	Bos taurus	179-184
1909368-4	1991	of hCG (n = 10/gilt) for 4 h at 37 degrees C in 95% O2:5% CO2.	Oxygen	52-54	chorionic gonadotropin subunit beta 5	Homo sapiens	3-6
8274159-8	1993	Whereas the N-hydroxylation of the guanidine involves the usual monooxygenase activity of cytochrome P450 the resultant N-hydroxyguanidine decouples monooxygenases (cytochrome P450, FMO) and the H2O2 and, above all, O2- thus formed transform the N-hydroxyguanidine further to the corresponding urea derivative.	Oxygen	197-199	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	101-105
8274159-8	1993	Whereas the N-hydroxylation of the guanidine involves the usual monooxygenase activity of cytochrome P450 the resultant N-hydroxyguanidine decouples monooxygenases (cytochrome P450, FMO) and the H2O2 and, above all, O2- thus formed transform the N-hydroxyguanidine further to the corresponding urea derivative.	Oxygen	197-199	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	176-180
17559924-10	2007	Expression of GLUT1 and G6PD mRNAs was correlated with respiration rates, indicating that, in metabolically active blastocysts, uptake of oxygen and glucose are jointly increased.	Oxygen	138-144	solute carrier family 2 member 1	Bos taurus	14-19
8279516-11	1993	These results demonstrate the role of CKB in buffering ATP levels and regulating intracellular pH during periods of low oxygen stress.	Oxygen	120-126	creatine kinase, brain	Mus musculus	38-41
17400601-4	2007	In this investigation, the hypothesis that O(2)-induced injury of the maturing lung is associated with TGF-beta-mediated disruption of alveologenesis and microvascular development was tested using a murine model of BPD.	Oxygen	43-47	transforming growth factor, beta 1	Mus musculus	103-111
7694816-8	1993	A single injection of rG-CSF restored both the depressed chemotaxis and the O2 production to levels greater than those of controls.	Oxygen	76-78	colony stimulating factor 3	Rattus norvegicus	22-28
2068118-8	1991	BALB/c mice had higher P50 (right-shifted O2 dissociation curves) and lower erythrocyte 2,3-diphosphoglycerate values than C3H mice, indicating a lower hemoglobin O2 affinity for BALB/c mice.	Oxygen	42-44	dynactin 2	Mus musculus	23-26
2036380-4	1991	The kinetics and CD spectra for chemically synthesized oligoribonucleotides with a Sp or Rp phosphorothioate diester bond at the cleavage site indicated that 1 mol of Mg2+ binds to the pro-R oxygen of phosphate.	Oxygen	191-197	mucin 7, secreted	Homo sapiens	167-170
2029516-1	1991	Overall association and dissociation rate constants were measured at 20 degrees C for O2, CO, and alkyl isocyanide binding to position 45 (CD3) mutants of pig and sperm whale myoglobins and to sperm whale myoglobin reconstituted with protoheme IX dimethyl ester.	Oxygen	86-88	myoglobin	Physeter catodon	175-184
12232001-8	1993	Therefore, the enhancement of the active oxygen-scavenging system that leads to increased oxidative stress protection in SOD+ plants could result not only from increased SOD levels but from the combined increases in SOD and APX activity.	Oxygen	41-47	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	224-227
17400601-5	2007	Here we report that treatment of developing mouse lungs with TGF-beta-neutralizing antibodies attenuates the increase in pulmonary cell phospho-Smad2 nuclear localization, which is indicative of augmented TGF-beta signaling, associated with pulmonary injury induced by chronic inhalation of 85% oxygen.	Oxygen	295-301	transforming growth factor, beta 1	Mus musculus	61-69
8240421-7	1993	In the presence of GSH, NADPH and ascorbic acid, Compound 2 redox cycled in reactions that catalyzed the oxidation of these cellular reductants by molecular oxygen and formed H2O2 as a byproduct.	Oxygen	157-163	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	24-29
1905254-1	1991	Cu/Zn superoxide dismutase (cSOD) is an important enzymatic agent of physiological defense against active oxygen species.	Oxygen	106-112	Superoxide dismutase 1	Drosophila melanogaster	0-26
17329595-7	2007	Oxygen-regulated expression of LDHA and SLC2A1 in bovine blastocysts suggests that regulation of these genes may be mediated by HIF2.	Oxygen	0-6	solute carrier family 2 member 1	Bos taurus	40-46
1905254-1	1991	Cu/Zn superoxide dismutase (cSOD) is an important enzymatic agent of physiological defense against active oxygen species.	Oxygen	106-112	Superoxide dismutase 1	Drosophila melanogaster	28-32
8107017-6	1993	Oxygen uptake by ram spermatozoa was inhibited (P &lt; 0.05) by the addition of 100 or 200 mumol HNE l-1.	Oxygen	0-6	elastase, neutrophil expressed	Homo sapiens	97-100
17498968-2	2007	We found that in vitro expansion of human postnatal brain CD133(+) nestin(+) precursors is enhanced at 5% oxygen, while raising oxygen tension to 20% depletes precursors and promotes astrocyte differentiation even in the presence of mitogens.	Oxygen	106-112	prominin 1	Homo sapiens	58-63
8399241-12	1993	These changes refer not only to heme a but also to heme a3, located remote from the cytochrome c binding site, pointing to a long-range structural communication between the binding domain and the oxygen reduction site.	Oxygen	196-202	LOC104968582	Bos taurus	84-96
2035236-7	1991	In most cases exposure to oxygen caused an increase in GSSG-R, GSH-Px and G-6-PD activities.	Oxygen	26-32	glucose-6-phosphate dehydrogenase	Rattus norvegicus	74-80
17498968-4	2007	This was reversed by noggin at 5%, but not 20%, oxygen due to a novel repressive effect of low oxygen on bone morphogenetic protein (BMP) signaling.	Oxygen	48-54	noggin	Homo sapiens	21-27
1676649-9	1991	O2 consumption was higher in adults than in newborns, in accordance with the lower metabolic capacity of the neonatal liver, supported by the lower values of cytochrome P-450, cytochrome c, and glutathione.	Oxygen	0-2	cytochrome P-450	Oryctolagus cuniculus	158-174
1676649-9	1991	O2 consumption was higher in adults than in newborns, in accordance with the lower metabolic capacity of the neonatal liver, supported by the lower values of cytochrome P-450, cytochrome c, and glutathione.	Oxygen	0-2	cytochrome c	Oryctolagus cuniculus	176-188
17498968-4	2007	This was reversed by noggin at 5%, but not 20%, oxygen due to a novel repressive effect of low oxygen on bone morphogenetic protein (BMP) signaling.	Oxygen	95-101	noggin	Homo sapiens	21-27
17542616-12	2007	Furthermore, flash oxygen yield analysis indicated that both the S2 and S3 states exhibited significantly longer lifetimes in the psbo1 mutant than in wild type.	Oxygen	19-25	PS II oxygen-evolving complex 1	Arabidopsis thaliana	130-135
1996664-7	1991	Exposure of adult rats to 95% O2 resulted in a five- to sixfold induction of ceruloplasmin mRNA in lung tissue within 46 h, and this response was time dependent, reaching maximum values at 86 h. Hyperoxic induction of ceruloplasmin mRNA was specific to the lung and not the result of systemic inflammation because hepatic ceruloplasmin mRNA content remained constant.	Oxygen	30-32	ceruloplasmin	Rattus norvegicus	77-90
7827969-5	1993	Since no assumptions concerning the p-orbital occupancies had to be invoked, these geometric eta formulae are valid for most bridging oxygens.	Oxygen	134-141	endothelin receptor type A	Homo sapiens	93-96
7827969-6	1993	A necessary prerequisite of the eta formulae was that the electron distribution around the oxygen atom under study should exhibit C2v or D2 symmetry.	Oxygen	91-97	endothelin receptor type A	Homo sapiens	32-35
8397143-0	1993	MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.	Oxygen	23-29	M-phase phosphoprotein 6	Homo sapiens	0-3
17307811-2	2007	Since hypoxia-inducible factors (HIFs) mediate the effects of both NO and VEGF in part through regulation by prolyl-hydroxylase-containing domains (PHDs) in the presence of oxygen, we hypothesized that HIF-1alpha and -2alpha in the lung are decreased following severe RDS in preterm neonatal lambs.	Oxygen	173-179	vascular endothelial growth factor A	Ovis aries	74-78
8397143-1	1993	MPP+ has been reported to inhibit reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase in mitochondria, which results in the formation of O2(.-).	Oxygen	148-150	M-phase phosphoprotein 6	Homo sapiens	0-3
8350431-5	1993	RESULTS: Both insulin-treated and untreated alloxan diabetic rabbits revealed significantly decreased oxygen tensions throughout the arterial wall compared with control rabbits.	Oxygen	102-108	insulin	Oryctolagus cuniculus	14-21
1899285-2	1991	In eucaryotes, the cytoplasmic form of the enzyme is a 32-kDa dimer containing two copper and two zinc atoms (CuZn SOD) that catalyzes the dismutation of the superoxide anion (O2-) to H2O2 and O2.	Oxygen	186-188	Superoxide dismutase 1	Drosophila melanogaster	110-118
1899285-4	1991	To understand the in vivo relationship between an efficient dismutation of O2- and oxidative injury to biological structures, we generated transgenic strains of Drosophila melanogaster overproducing CuZn SOD.	Oxygen	75-77	Superoxide dismutase 1	Drosophila melanogaster	199-207
17360214-2	2007	The functional mutation of Met-32D(B13)-Leu of alpha(D) globin chain was related with hypoxia based on allele distribution, homology model building and oxygen affinity assay.	Oxygen	152-158	hemoglobin alpha, subunit D	Gallus gallus	47-62
1986398-0	1991	The effect of irradiation in air or in hyperbaric oxygen on the Fib/T tumor in WHT mice pretreated with a hypoxic gas mixture.	Oxygen	50-56	fibrinogen alpha chain	Mus musculus	64-67
1986398-2	1991	The response of the Fib/T tumor to radiation delivered in air was improved both by a 48-h and by a 72-h exposure of the animals to 8, 10, and 15% oxygen.	Oxygen	146-152	fibrinogen alpha chain	Mus musculus	20-23
8415909-4	1993	Among the different quenchers tested, oxygen quenching alone was sensitive to calcium binding to the ATPase, indicating that oxygen quenched tryptophan residues located in regions of the ATPase molecule which undergo conformational changes upon calcium binding.	Oxygen	38-44	dynein axonemal heavy chain 8	Homo sapiens	101-107
8415909-4	1993	Among the different quenchers tested, oxygen quenching alone was sensitive to calcium binding to the ATPase, indicating that oxygen quenched tryptophan residues located in regions of the ATPase molecule which undergo conformational changes upon calcium binding.	Oxygen	38-44	dynein axonemal heavy chain 8	Homo sapiens	187-193
8415909-4	1993	Among the different quenchers tested, oxygen quenching alone was sensitive to calcium binding to the ATPase, indicating that oxygen quenched tryptophan residues located in regions of the ATPase molecule which undergo conformational changes upon calcium binding.	Oxygen	125-131	dynein axonemal heavy chain 8	Homo sapiens	101-107
8415909-4	1993	Among the different quenchers tested, oxygen quenching alone was sensitive to calcium binding to the ATPase, indicating that oxygen quenched tryptophan residues located in regions of the ATPase molecule which undergo conformational changes upon calcium binding.	Oxygen	125-131	dynein axonemal heavy chain 8	Homo sapiens	187-193
8343587-5	1993	The turn structure in each of these peptides is stabilized by an intramolecular H bond between the carbonyl oxygen of Gly1 and the amide proton of D-Phe4.	Oxygen	108-114	threonine aldolase 1, pseudogene	Homo sapiens	118-122
2085750-10	1990	Basic fibroblast growth factor and epidermal growth factor also had a potent effect to rescue the cell death in the high O2 culture, but insulin had no effect.	Oxygen	121-123	fibroblast growth factor 2	Rattus norvegicus	0-30
2260678-1	1990	Tracheal insufflation of tumor necrosis factor (TNF) enhances pulmonary antioxidant enzyme activities and protects rats against oxygen toxicity (J. Appl.	Oxygen	128-134	tumor necrosis factor-like	Rattus norvegicus	25-46
2260678-1	1990	Tracheal insufflation of tumor necrosis factor (TNF) enhances pulmonary antioxidant enzyme activities and protects rats against oxygen toxicity (J. Appl.	Oxygen	128-134	tumor necrosis factor-like	Rattus norvegicus	48-51
2260678-8	1990	The results suggest that the increased pulmonary Mn-SOD in TNF-insufflated rats may contribute to the TNF-induced protection against oxygen toxicity.	Oxygen	133-139	tumor necrosis factor-like	Rattus norvegicus	59-62
8516341-2	1993	Evidence suggests that both CuZnSOD and MnSOD are important in pulmonary defense against oxygen toxicity.	Oxygen	89-95	superoxide dismutase 2	Homo sapiens	40-45
8516341-4	1993	Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity.	Oxygen	164-170	superoxide dismutase 2	Homo sapiens	39-44
17512623-7	2007	RESULTS: In both SiHa and FaDu(DD) cells Ca9 and LOX reached the highest level of expression at 1% oxygen.	Oxygen	99-105	carbonic anhydrase 9	Homo sapiens	41-44
8516341-4	1993	Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity.	Oxygen	164-170	superoxide dismutase 2	Homo sapiens	73-78
8334438-5	1993	At least two distinct phenotypes were found among the strains exposed to O2 for 72 h. The susceptible phenotype (exemplified by C57BL/6J [B6] mice) was characterized by mean BAL protein concentration that was approximately 10 times greater than the resistant phenotype (e.g. C3H/HeJ [C3] mice).	Oxygen	73-75	complement component 3	Mus musculus	275-282
2230541-6	1990	In oxygen-exposed fed mice, GP increased 62% and GR increased 39% on day 4 (p less than 0.05), the time when the lung injury was most severe; glutathione increased 30% on days 3 and 4 (p less than 0.05); and GSSG increased threefold and eightfold on days 3 and 4 (p less than 0.01).	Oxygen	3-9	glutathione reductase	Mus musculus	49-51
17374610-11	2007	Our findings indicate that transcription of the NTRK2 gene is stimulated at low oxygen tension through a HIF-1-dependent mechanism.	Oxygen	80-86	neurotrophic receptor tyrosine kinase 2	Homo sapiens	48-53
2277471-8	1990	The frequency of exertional dyspnea, O2 demand, acute exacerbation, and artificial ventilation increased in the order A-B-C.	Oxygen	37-39	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	118-123
8334438-5	1993	At least two distinct phenotypes were found among the strains exposed to O2 for 72 h. The susceptible phenotype (exemplified by C57BL/6J [B6] mice) was characterized by mean BAL protein concentration that was approximately 10 times greater than the resistant phenotype (e.g. C3H/HeJ [C3] mice).	Oxygen	73-75	complement component 3	Mus musculus	275-277
17478157-11	2007	Patients with BNP release (vs patients without) had higher maximum oxygen consumption (19.2 +/- 5.1 vs 15.9 +/- 3.6, p &lt;0.001), better functional capacity (59 +/- 13% vs 50 +/- 15%, p = 0.002), and lower minute ventilation/carbon dioxide production slope (33.6 +/- 4.8 vs 36.5 +/- 7.7, p = 0.026) independent of other clinical parameters.	Oxygen	67-73	natriuretic peptide B	Homo sapiens	14-17
7683651-5	1993	Imidazole inhibited calmodulin-dependent NADPH consumption by the enzyme with dissolved oxygen as the sole electron acceptor, with half-maximal inhibition occurring at a concentration of 225 microM.	Oxygen	88-94	calmodulin 1	Rattus norvegicus	20-30
8388647-6	1993	When lung tissues that had been maintained for 5 days in 1% oxygen were transferred to an environment containing 20% oxygen, there was rapid morphological development and induction of SP-A gene expression.	Oxygen	60-66	surfactant protein A1	Homo sapiens	184-188
2074532-4	1990	The amide carbonyl oxygen at 6-position is considered to coordinate with the reagent, because the largest downfield shifts were observed at the amide carbonyl carbon (C-6) in 13C-NMR and the amide hydrogen (H-7) in 1H-NMR.	Oxygen	19-25	complement C6	Homo sapiens	167-170
17449423-7	2007	RESULTS: Plasma levels of NT Pro BNP correlated significantly with peak oxygen consumption (VO(2)) values (r = -0.77, p &lt; 0.001).	Oxygen	72-78	natriuretic peptide B	Homo sapiens	33-36
11607104-5	1990	LB3+ reductase converts 215 nmol of LB3+ to LB2+.CO (or Lb2+.O2) per mg of protein per min and does not require an exogenous electron carrier.	Oxygen	61-63	chalcone reductase CHR1	Glycine max	5-14
8388647-6	1993	When lung tissues that had been maintained for 5 days in 1% oxygen were transferred to an environment containing 20% oxygen, there was rapid morphological development and induction of SP-A gene expression.	Oxygen	117-123	surfactant protein A1	Homo sapiens	184-188
8388647-8	1993	Our findings further suggest that the effects of oxygen on the levels of SP-A and SP-A mRNA are concentration dependent.	Oxygen	49-55	surfactant protein A1	Homo sapiens	73-77
8388647-8	1993	Our findings further suggest that the effects of oxygen on the levels of SP-A and SP-A mRNA are concentration dependent.	Oxygen	49-55	surfactant protein A1	Homo sapiens	82-86
8388647-9	1993	Interestingly, the inductive effects of DBcAMP on SP-A gene expression were apparent only at oxygen concentrations &gt; or = 10%.	Oxygen	93-99	surfactant protein A1	Homo sapiens	50-54
17462012-3	2007	We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway.	Oxygen	116-122	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	49-90
8098618-10	1993	In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.	Oxygen	105-111	CD28 molecule	Homo sapiens	19-23
15815330-3	1990	Regional cerebral metabolic rate for oxygen (rCMRO2) was calculated as rCBF multiplied by the arteriosagittal sinus oxygen content difference.	Oxygen	37-43	CCAAT/enhancer binding protein zeta	Rattus norvegicus	71-75
17462012-3	2007	We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway.	Oxygen	116-122	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	92-97
1970924-1	1990	We have recently suggested that relaxation of isolated precontracted intrapulmonary arteries from calves to H2O2 or O2 may involve the activation of guanylate cyclase by peroxide metabolism via catalase.	Oxygen	110-112	catalase	Bos taurus	194-202
2383294-5	1990	CDP-choline showed a protective effect increasing vigilance under mild (15% O2) hypoxia, indicating the possibility of treatment of patients with cerebral syndromes secondary to hypoxia.	Oxygen	76-78	cut like homeobox 1	Homo sapiens	0-3
8462004-5	1993	In this study, rats treated with an MAO inhibitor (pargyline) or a nitric oxide synthase inhibitor (LNNA) were protected against O2-induced convulsions.	Oxygen	129-131	monoamine oxidase A	Rattus norvegicus	36-39
8089441-0	1993	The relationship between fetal arterial oxygen saturation and heart and skeletal muscle myoglobin concentrations in the ovine fetus.	Oxygen	40-46	myoglobin	Ovis aries	88-97
17353442-0	2007	Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.	Oxygen	0-6	ras homolog family member B	Homo sapiens	56-60
8447389-3	1993	NPY lowered BAT metabolism and whole body oxygen consumption and raised plasma insulin concentrations within 30 min in adrenalectomized ob/ob mice similarly to dexamethasone; but, unlike dexamethasone, NPY was as effective in modulating these metabolic responses in adrenalectomized lean mice as in ob/ob mice.	Oxygen	42-48	neuropeptide Y	Mus musculus	0-3
8435086-2	1993	The aim was to gain more information on which isoenzymes of PKC are involved in neutrophil activation, specifically inhibition of fMet-Leu-Phe (fMLP)-stimulated bivalent cation influx and stimulation of O2-.	Oxygen	203-205	protein kinase C beta	Homo sapiens	60-63
2333969-8	1990	These results suggest that massive quantities of XDH and XO are released into the circulation after hepatic ischemia and that the resulting reactive oxygen metabolites could produce widespread tissue injury.	Oxygen	149-155	xanthine dehydrogenase	Rattus norvegicus	49-52
17353442-0	2007	Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.	Oxygen	0-6	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	65-71
2155924-2	1990	The activities of adenosine deaminase (ADA) and xanthine oxidase (XO), which generates O2-, were elevated in the s-BALF, lung tissue homogenate, and serum (plasma).	Oxygen	87-90	adenosine deaminase	Mus musculus	18-37
17187281-1	2007	Animal experiments were performed to investigate whether and how the administration of hyperbaric oxygen (HBO) affects gene expressions of procollagens, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in injured medial collateral ligament (MCL) and anterior cruciate ligament (ACL).	Oxygen	98-104	matrix metallopeptidase 2	Rattus norvegicus	180-184
2155924-2	1990	The activities of adenosine deaminase (ADA) and xanthine oxidase (XO), which generates O2-, were elevated in the s-BALF, lung tissue homogenate, and serum (plasma).	Oxygen	87-90	adenosine deaminase	Mus musculus	39-42
2081152-1	1990	We have produced a compact, lightweight oxygen concentrator, using a newly-developed polymer of poly [1-(trimethylsilyl)-1-propyne] with a performance, i.e. oxygen permeability, of 61 x 10 cm3 (STP) cm/cm2 s cmHg, which is 17 times higher than that of the membrane material of conventional concentrators.	Oxygen	40-46	sulfotransferase family 1A member 1	Homo sapiens	194-197
7680974-6	1993	Cytokeratin 19 was also found in microvessels of the rete mirabile, an oxygen exchange organ of the eel.	Oxygen	71-77	keratin 19	Bos taurus	0-14
8358221-4	1993	The other fraction, which flowed through the column, was assumed to contain the terminal enzyme which accepts electrons from cytochrome b5, activates oxygen, and catalyses the hydroxylation of CMP-NeuAc.	Oxygen	150-156	cytochrome b5 type A (microsomal)	Mus musculus	125-138
17376234-15	2007	The SDHA variants that have increased in frequency during human evolution might, by influencing the regulation of cellular oxygen homeostasis, confer protection against certain environmental toxins or pathogens that are prevalent in Africa.	Oxygen	123-129	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	4-8
8426908-7	1993	Human TGF alpha was only effective in inhibiting carbachol if incubations were performed in the presence of air rather than 100% O2.	Oxygen	129-131	transforming growth factor alpha	Homo sapiens	6-15
8426908-9	1993	The human sequence fragments, like the native human TGF alpha, elicited no inhibition when incubations were performed in the presence of 100% O2.	Oxygen	142-144	transforming growth factor alpha	Homo sapiens	52-61
33769637-2	2021	Formation of the oxidized nucleotides hmdC, fdC and cadC requires oxidation of mdC by ten-eleven translocation (Tet) enzymes that require oxygen, Fe(II) and a-ketoglutarate as cosubstrates.	Oxygen	138-144	C-C motif chemokine ligand 22	Homo sapiens	39-42
33972668-4	2021	Mechanistically, MFN2 was required for the enhancement of inflammatory signaling through optimal induction of aerobic glycolysis via HIF-1alpha, which is activated by mitochondrial respiratory chain complex I and reactive oxygen species, in macrophages.	Oxygen	222-228	mitofusin 2	Mus musculus	17-21
17320763-7	2007	The results indicated that NOS1-catalyzed NO production was significantly more sensitive to ambient O(2) concentration than that catalyzed by NOS3.	Oxygen	100-104	nitric oxide synthase 1	Homo sapiens	27-31
33819816-3	2021	PTP can achieve near infrared (NIR) O2 concentration ratiometric imaging, solving the problems of short detection wavelengths and influence of self-concentrations.	Oxygen	36-38	protein tyrosine phosphatase receptor type U	Homo sapiens	0-3
8421499-4	1993	A DNA substrate, in which the bridging 3" oxygen atom at the cleavage site is replaced by sulphur, is cleaved by the ribozyme about 1,000 times more slowly than the corresponding unmodified DNA substrate when Mg2+ is present as the only divalent metal ion.	Oxygen	42-48	mucin 7, secreted	Homo sapiens	209-212
8421499-6	1993	Considering that Mn2+ and Zn2+ coordinate sulphur more strongly than Mg2+ does, these results indicate that the metal ion contributes directly to catalysis by coordination to the 3" oxygen atom in the transition state, presumably stabilizing the developing negative charge on the leaving group.	Oxygen	182-188	mucin 7, secreted	Homo sapiens	69-72
17320763-8	2007	Also, the high sensitivity of NOS1 catalytic activity to O(2) was associated with significantly reduced NO production and therefore NO concentrations, upon hypoxia.	Oxygen	57-61	nitric oxide synthase 1	Homo sapiens	30-34
1476771-4	1992	The ability of PHB to solvate salts, consisting of cations having high solvation energies and large delocalized anions, is in accordance with its molecular characteristics, that of a flexible linear molecule possessing a large number of electron-donating ester oxygens suitably spaced to replace the hydration shell of cations.	Oxygen	261-268	prohibitin 1	Homo sapiens	15-18
17578311-1	2007	OBJECTIVE: To study, through blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI), the cerebral activated areas evoked by electro-acupuncturing (EA) the right Hegu point (L14) or non-acupoint points on the face, and through comparing their similarities and differences, to speculate on the specific cerebral areas activated by stimulating L14, for exploring the mechanism of its effect in potential clinical application.	Oxygen	35-41	immunoglobulin kappa variable 1D-17	Homo sapiens	197-200
1328233-2	1992	Unlike XO, which reacts rapidly only with oxygen and not with NAD, the XDH form of the enzyme reacts rapidly with NAD.	Oxygen	42-48	xanthine dehydrogenase	Homo sapiens	71-74
1328233-3	1992	XDH has a turnover number for the NAD-dependent conversion of xanthine to urate of 380 mol/min/mol at pH 7.5, 25 degrees C, with a Km = &lt; or = 1 microM for xanthine and a Km = 7 microM for NAD, but has very little O2-dependent activity.	Oxygen	217-219	xanthine dehydrogenase	Homo sapiens	0-3
1329770-13	1992	These findings suggest that the mechanism of inhibition of GR by flavonoids is complex and may have oxygen-dependent and oxygen-independent components.	Oxygen	100-106	glutathione-disulfide reductase	Homo sapiens	59-61
1329770-13	1992	These findings suggest that the mechanism of inhibition of GR by flavonoids is complex and may have oxygen-dependent and oxygen-independent components.	Oxygen	121-127	glutathione-disulfide reductase	Homo sapiens	59-61
1415803-6	1992	Leg O2 uptake was the same for Ex1 and Ex2.	Oxygen	4-6	FERM domain containing 6	Homo sapiens	31-34
33812256-0	2021	Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.	Oxygen	32-38	dipeptidyl peptidase 3	Homo sapiens	0-22
33812256-2	2021	The goals of this work were to evaluate the role of DPP3 in the regulation of oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis, oxidative stress and inflammation in HT22 hippocampal neurons.	Oxygen	78-84	dipeptidyl peptidase 3	Homo sapiens	52-56
33803527-2	2021	The purpose of the research was to study the effect of the relative oxygen concentration O2(x) = O2/(N2 + O2) in particular on adhesion, but also on the color, structural and mechanical properties of ZrON coatings synthesized by cathodic arc evaporation on HS6-5-2 steel substrates.	Oxygen	68-74	activity regulated cytoskeleton associated protein	Homo sapiens	23-26
33803527-2	2021	The purpose of the research was to study the effect of the relative oxygen concentration O2(x) = O2/(N2 + O2) in particular on adhesion, but also on the color, structural and mechanical properties of ZrON coatings synthesized by cathodic arc evaporation on HS6-5-2 steel substrates.	Oxygen	89-91	activity regulated cytoskeleton associated protein	Homo sapiens	23-26
33803527-2	2021	The purpose of the research was to study the effect of the relative oxygen concentration O2(x) = O2/(N2 + O2) in particular on adhesion, but also on the color, structural and mechanical properties of ZrON coatings synthesized by cathodic arc evaporation on HS6-5-2 steel substrates.	Oxygen	97-99	activity regulated cytoskeleton associated protein	Homo sapiens	23-26
33352493-0	2021	Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.	Oxygen	45-51	Dopamine receptor 3	Caenorhabditis elegans	116-120
19069852-6	2007	During the study period dissolved oxygen show direct relation with water temperature but inverse with BOD and COD.	Oxygen	34-40	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	110-113
28179905-8	2017	MIF and DDT levels correlated with concentrations of vascular endothelial growth factor, a protein upregulated under low oxygen tension and implicated in vascular and lung development (R = 0.70, P &lt; 0.0001 for MIF and R = 0.65, P &lt; 0.0001 for DDT).	Oxygen	121-127	macrophage migration inhibitory factor	Homo sapiens	0-3
1467354-2	1992	During the first 24 hours after injection both carnosine and 4-methyluracil increase the activity of adenosine deaminase and purine nucleoside phosphorylase, the key enzymes of purine catabolism which is the main source of O2-.	Oxygen	223-225	adenosine deaminase	Mus musculus	101-120
1321713-6	1992	Ferricytochrome c was effectively reduced by calf thymus thioredoxin reductase and selenite in the presence of oxygen.	Oxygen	111-117	thioredoxin	Bos taurus	57-68
17217981-3	2007	Of the biomass characteristics studied, only solids concentration (correlated with viscosity), the carbohydrate fraction of the EPS (EPS(c)) and the chemical oxygen demand (COD) concentration of the SMP (SMP(COD)) were found to affect the oxygen transfer parameters k(L)a(20) (the oxygen transfer coefficient) and alpha-factor.	Oxygen	239-245	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	204-212
24751879-1	2014	Wnt/beta-catenin signaling induced by the Norrin/Frizzled-4 pathway has been shown to improve capillary repair following oxygen induced retinopathy (OIR) in the mouse, a model for retinopathy of prematurity.	Oxygen	121-127	Norrie disease (pseudoglioma) (human)	Mus musculus	42-48
17217981-3	2007	Of the biomass characteristics studied, only solids concentration (correlated with viscosity), the carbohydrate fraction of the EPS (EPS(c)) and the chemical oxygen demand (COD) concentration of the SMP (SMP(COD)) were found to affect the oxygen transfer parameters k(L)a(20) (the oxygen transfer coefficient) and alpha-factor.	Oxygen	239-245	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	204-212
24751879-1	2014	Wnt/beta-catenin signaling induced by the Norrin/Frizzled-4 pathway has been shown to improve capillary repair following oxygen induced retinopathy (OIR) in the mouse, a model for retinopathy of prematurity.	Oxygen	121-127	frizzled class receptor 4	Mus musculus	49-59
1428538-2	1992	One carbonyl oxygen of the cyclic hexapeptide cyclo(-Gly1-Pro2-Phe3-Val4-Phe5-Phe6-) (A) can be selectively exchanged with sulphur using Yokoyama"s reagent.	Oxygen	13-19	threonine aldolase 1, pseudogene	Homo sapiens	53-57
1428538-2	1992	One carbonyl oxygen of the cyclic hexapeptide cyclo(-Gly1-Pro2-Phe3-Val4-Phe5-Phe6-) (A) can be selectively exchanged with sulphur using Yokoyama"s reagent.	Oxygen	13-19	dihydrolipoamide dehydrogenase	Homo sapiens	63-67
17031858-4	2007	Our studies show that osteoblasts respond to hypoxia (2% oxygen) by enhancing expression of genes associated with adipocyte/lipogenesis phenotype (C/EBPbeta, PPARgamma2, and aP2) and by suppressing expression of genes associated with osteoblast differentiation (alkaline phosphatase, AP).	Oxygen	57-63	CCAAT enhancer binding protein beta	Homo sapiens	147-156
1570917-6	1992	Hb-H is an exception to this generalization; as in patients with carboxyhemoglobinemia, pulse oximetry measurements showing high O2 saturation percentage do not correspond to high levels of oxygen available for delivery to tissues.	Oxygen	129-131	hemoglobin subunit alpha 1	Homo sapiens	0-4
12849743-2	2003	The in vitro studies of organotypic cultures from hippocampus evidenced that P2X2 and P2X4 were up-regulated by glucose/oxygen deprivation.	Oxygen	120-126	purinergic receptor P2X 4	Homo sapiens	86-90
17071723-7	2007	Exposure of primary lung fibroblasts to 85% O(2) significantly enhanced the TGF-beta-stimulated production of the alpha(1) subunit of type I collagen (Ialpha(1)), tissue inhibitor of metalloproteinase-1, tropoelastin, and tenascin-C.	Oxygen	44-48	tenascin C	Mus musculus	222-232
7579170-7	1995	Our results suggest that AtOZI1 represents a novel stress-related protein that accumulates in response to the production of active oxygen species.	Oxygen	131-137	monopolar spindle protein (DUF1138)	Arabidopsis thaliana	25-31
1528981-3	1992	The pH dependence of the decay of the transient reduced complex, in the presence of an oxidant (oxygen or benzoquinone) indicates the formation of Ru(tap)2(tapH)2+, i.e. the reduced protonated species, subsequent to the electron transfer, with a pKa of 7.6 as confirmed from pulse radiolysis experiments.	Oxygen	96-102	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	147-155
17101723-1	2007	Oxygen insensitivity of carcinoma cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) enables detection of carcinoma cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	0-6	glucose-6-phosphate dehydrogenase	Rattus norvegicus	113-146
1390332-6	1992	On nifedipine, breathing oxygen resulted in, independent of age, a significant increase in QP/QS (p less than 0.003) and a significant decrease in PAP/PAO (p less than 0.04) and in RP/RS (p less than 0.003).	Oxygen	25-31	spermine oxidase	Homo sapiens	151-154
1592491-4	1992	In the primed cells, however, extracellular release of reactive oxygen metabolites was significantly increased during Fc- and CR3-mediated phagocytosis (P less than 0.01 and P less than 0.002, respectively).	Oxygen	64-70	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	126-129
1541127-7	1992	There was a trend toward increased survival in 35 oxygen-treated vs 38 non-oxygen-treated NOD subjects (definition 1), but this difference was not statistically significant.	Oxygen	75-81	atrophin 1	Homo sapiens	90-93
34673391-3	2022	Intriguingly, the analytical results for degradation intermediates and other characterization techniques demonstrate that the pollutants adsorbed on the graphitized C of BiOBr-Cg can be directly excited through light irradiation and react along the organic radical degradation pathway in addition to pollutant degradation by holes and HO2 /O2 -.	Oxygen	340-344	heme oxygenase 2	Homo sapiens	335-338
34488090-5	2022	In addition, we show that reactive oxygen species produced by NPs exposure and peroxiredoxin-2 (PRDX-2) are related to the disturbed circadian rhythms.	Oxygen	35-41	Peroxiredoxin prdx-2	Caenorhabditis elegans	79-94
34488090-5	2022	In addition, we show that reactive oxygen species produced by NPs exposure and peroxiredoxin-2 (PRDX-2) are related to the disturbed circadian rhythms.	Oxygen	35-41	Peroxiredoxin prdx-2	Caenorhabditis elegans	96-102
17101723-1	2007	Oxygen insensitivity of carcinoma cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) enables detection of carcinoma cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	0-6	glucose-6-phosphate dehydrogenase	Rattus norvegicus	148-152
17101723-1	2007	Oxygen insensitivity of carcinoma cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) enables detection of carcinoma cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	44-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	113-146
34871799-1	2022	In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (VO2) kinetics.	Oxygen	227-233	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	64-94
1346398-5	1992	However, mAbs against LFA-1 or gp150/95 triggered both H2O2 and O2- release from neutrophils.	Oxygen	57-59	integrin subunit beta 4	Homo sapiens	31-36
17101723-1	2007	Oxygen insensitivity of carcinoma cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) enables detection of carcinoma cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	44-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	148-152
34871799-1	2022	In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (VO2) kinetics.	Oxygen	227-233	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	96-99
34871799-3	2022	We tested the hypotheses that sGC activator administration would increase the O2 delivery (QO2)-to-VO2 ratio in the skeletal muscle interstitial space (PO2is) of HFrEF rats during twitch contractions due, in part, to increases in red blood cell (RBC) flux (fRBC), velocity (VRBC), and capillary hematocrit (Hctcap).	Oxygen	78-80	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	30-33
17321223-3	2007	We have shown that a mutation in a subunit, cytochrome b large subunit (SDHC), of complex II, also results in increasing O2- production and therefore lead to apoptosis and precocious aging in Caenorhabditis elegans.	Oxygen	121-123	cytochrome b	Caenorhabditis elegans	44-56
1337658-1	1992	The cellular oxygen supply in the isolated, hemoglobin-free perfused, working rat heart can be determined by measurements of myoglobin oxygenation.	Oxygen	13-19	myoglobin	Rattus norvegicus	125-134
34846075-4	2022	For the first time in the M II M III Si 4 N 7 compound class, complementary EDX measurements suggest that simultaneous incorporation of oxygen compensates for the negative charge excess induced by C, resulting in an adjusted sum formula, CaLu(Si 4 N 7-2 x C x O x ) ( x   0.3).	Oxygen	136-142	calumenin	Homo sapiens	238-242
17255293-3	2007	The VHL gene product, pVHL, is part of a ubiquitin ligase complex that targets the alpha-subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF) for polyubiquitylation, and hence, proteasomal degradation, when oxygen is available.	Oxygen	236-242	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
34928569-2	2022	In this study, the computation-ready experimental (CoRE) metal-organic framework (MOF) data set for which the O2 and N2 uptakes, self-diffusivities, and Henry"s constants were calculated was used to fit the ML models.	Oxygen	110-112	lysine acetyltransferase 8	Homo sapiens	82-85
1736329-5	1992	The effect of a 48 h 8% oxygen exposure in modifying the response of the Fib/T tumour to two fractions of radiation, both delivered in hyperbaric oxygen, was also investigated.	Oxygen	24-30	fibrinogen alpha chain	Mus musculus	73-76
17255293-3	2007	The VHL gene product, pVHL, is part of a ubiquitin ligase complex that targets the alpha-subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF) for polyubiquitylation, and hence, proteasomal degradation, when oxygen is available.	Oxygen	236-242	von Hippel-Lindau tumor suppressor	Homo sapiens	22-26
34928569-3	2022	The obtained models were subsequently employed to predict such properties for a hypothetical MOF (hMOF) data set and to identify structures having a high O2/N2 selectivity at room temperature.	Oxygen	154-156	lysine acetyltransferase 8	Homo sapiens	93-96
17201391-0	2007	Reaction of O2 with the hydrogen atom in water up to 350 degrees C. The reaction of the H* atom with O2, giving the hydroperoxyl HO2* radical, has been investigated in pressurized water up to 350 degrees C using pulse radiolysis and deep-UV transient absorption spectroscopy.	Oxygen	12-14	heme oxygenase 2	Homo sapiens	129-132
34928569-3	2022	The obtained models were subsequently employed to predict such properties for a hypothetical MOF (hMOF) data set and to identify structures having a high O2/N2 selectivity at room temperature.	Oxygen	154-156	lysine acetyltransferase 8	Homo sapiens	98-102
1962563-1	1991	The biosynthesis of all alpha-amidated peptides requires the participation of peptidylglycine alpha-amidating monooxygenase (PAM), a bifunctional enzyme dependent on molecular oxygen, ascorbate, and copper.	Oxygen	114-120	peptidylglycine alpha-amidating monooxygenase	Mus musculus	125-128
16940473-11	2007	Hence, three experimental models of placental hypoxia (early gestation, DMOG treatment, and high altitude) converge in stimulating increased MIF, supporting the conclusion that placental-derived MIF is an oxygen-responsive cytokine highly expressed in physiological in vivo and in in vitro low oxygen conditions.	Oxygen	205-211	macrophage migration inhibitory factor	Homo sapiens	141-144
16940473-11	2007	Hence, three experimental models of placental hypoxia (early gestation, DMOG treatment, and high altitude) converge in stimulating increased MIF, supporting the conclusion that placental-derived MIF is an oxygen-responsive cytokine highly expressed in physiological in vivo and in in vitro low oxygen conditions.	Oxygen	205-211	macrophage migration inhibitory factor	Homo sapiens	195-198
1662913-7	1991	These studies indicate that during a short-term nonlethal TNF infusion, Kupffer cells are a major target of TNF action, leading to the release of toxic-oxygen metabolites that may contribute to organ failure.	Oxygen	152-158	tumor necrosis factor-like	Rattus norvegicus	58-61
1662913-7	1991	These studies indicate that during a short-term nonlethal TNF infusion, Kupffer cells are a major target of TNF action, leading to the release of toxic-oxygen metabolites that may contribute to organ failure.	Oxygen	152-158	tumor necrosis factor-like	Rattus norvegicus	108-111
1958377-2	1991	Acute exposure to 100% O2 results in severe decreases in respiratory function and is accompanied by alterations in pulmonary surfactant metabolism, including the regulation of surfactant proteins A, B, and C (SP-A, SP-B, SP-C).	Oxygen	23-25	surfactant protein A1	Homo sapiens	176-207
1958377-2	1991	Acute exposure to 100% O2 results in severe decreases in respiratory function and is accompanied by alterations in pulmonary surfactant metabolism, including the regulation of surfactant proteins A, B, and C (SP-A, SP-B, SP-C).	Oxygen	23-25	surfactant protein A1	Homo sapiens	209-213
1958377-2	1991	Acute exposure to 100% O2 results in severe decreases in respiratory function and is accompanied by alterations in pulmonary surfactant metabolism, including the regulation of surfactant proteins A, B, and C (SP-A, SP-B, SP-C).	Oxygen	23-25	surfactant protein B	Homo sapiens	215-219
34896699-5	2022	Pharmacological and genetic manipulation revealed that the Ca2+ response to light was triggered by extracellular Ca2+ entry through TRPV1, whose activation required the production of reactive oxygen species at the interface between rr-P3HT and the cell membrane.	Oxygen	192-198	transient receptor potential cation channel subfamily V member 1	Homo sapiens	132-137
34623600-12	2022	Finally, a combined bioinformatics and biochemical analysis of the mitochondrial oxygen consumption rate revealed that NME1 enhanced mitochondrial function, which is known to be impaired in PD.	Oxygen	81-87	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	119-123
34800627-6	2022	Activation of mitochondrial ATP-sensitive potassium channels (mitoKATP) channels, uncoupling proteins, and inhibition of glycogen synthase kinase-3beta (GSK3beta) phosphorylation have been identified to delay mitochondrial permeability transition pore opening and reduce reactive oxygen species formation, thereby decreasing infarct size.	Oxygen	280-286	glycogen synthase kinase 3 beta	Homo sapiens	121-151
1726709-1	1991	Interleukin-8 (IL-8) stimulated an increase in cytoplasmic-free Ca2+ ([Ca2+]i) and intracellular pH (pHi) in parallel at low concentrations (0.5 to 5 ng/mL), and stimulated O2- release and membrane depolarization in parallel at high concentrations (50 to 5,000 ng/mL).	Oxygen	173-175	glucose-6-phosphate isomerase	Homo sapiens	101-104
34800627-6	2022	Activation of mitochondrial ATP-sensitive potassium channels (mitoKATP) channels, uncoupling proteins, and inhibition of glycogen synthase kinase-3beta (GSK3beta) phosphorylation have been identified to delay mitochondrial permeability transition pore opening and reduce reactive oxygen species formation, thereby decreasing infarct size.	Oxygen	280-286	glycogen synthase kinase 3 alpha	Homo sapiens	153-161
16940473-11	2007	Hence, three experimental models of placental hypoxia (early gestation, DMOG treatment, and high altitude) converge in stimulating increased MIF, supporting the conclusion that placental-derived MIF is an oxygen-responsive cytokine highly expressed in physiological in vivo and in in vitro low oxygen conditions.	Oxygen	294-300	macrophage migration inhibitory factor	Homo sapiens	195-198
17474298-12	2007	Recent data have shown that SDF-1 expression is directly proportional to reduced tissue oxygen tension.	Oxygen	88-94	C-X-C motif chemokine ligand 12	Homo sapiens	28-33
34987704-10	2021	Jun was found to be associated with hypoxia in endothelial cells, whereas Irf9 and Etv5 were identified as astrocyte-specific TFs associated with oxygen concentration in the mouse cerebral cortex.	Oxygen	146-152	ets variant 5	Mus musculus	83-87
1928358-4	1991	The cellular enlargement produced by TGF-beta 1 in room air was attenuated in the presence of anoxia, indicating a need for O2 for TGF-beta 1 to have an effect on cell size.	Oxygen	124-126	transforming growth factor beta 1	Bos taurus	131-141
1928397-5	1991	Inactivation of intracellular myoglobin with 1-2 mM sodium nitrite, which reduces the steady-state respiratory oxygen consumption rate by 30%, caused a significant (30%) decrease in intracellular phosphocreatine peak, which was reversed upon removal of sodium nitrite.	Oxygen	111-117	myoglobin	Rattus norvegicus	30-39
17432925-11	2007	Other effective therapies for the treatment of acute exacerbations of COPD include oxygen and non-invasive ventilation.	Oxygen	83-89	COPD	Homo sapiens	70-74
1833195-7	1991	Beta-1 adrenoceptor agonists increase myocardial oxygen consumption.	Oxygen	49-55	adrenoceptor beta 1	Homo sapiens	0-19
34438153-5	2021	Following the initial reactions, their subsequent reactions with O2 and HO2 (or NO) under different atmospheric conditions could lead to the formation of 17 highly oxidized molecules (HOMs), of which P10, P12, P16, P17, P19 and P33 generated by the subsequent reactions of the major first-generation products (MVK, CMBO, CMBA and MBO) have been detected in the reaction process of isoprene with Cl in the chamber experiment.	Oxygen	65-67	mevalonate kinase	Homo sapiens	310-313
17045587-9	2007	Thus, reduced oxygen levels lead to activation of the Dll4-Notch-Hey2 signaling cascade and subsequent repression of COUP-TFII in endothelial progenitor cells.	Oxygen	14-20	hes related family bHLH transcription factor with YRPW motif 2	Homo sapiens	65-69
34919733-5	2022	Oxygen consumption rate measurements in aox1a and aox1d leaves suggested these AOXs can functionally compensate for each other to establish enhanced AOX catalytic capacity in response to Pro.	Oxygen	0-6	alternative oxidase 1A	Arabidopsis thaliana	40-45
1956126-7	1991	2) After training, both heart rates and oxygen uptake during submaximal work loads significantly decreased in group H, but only heart rates significantly decreased in group L. 3) Heart rates with a same oxygen-uptake load during submaximal work seemed to increase in group H, but significantly decreased in group L. 4) The mechanical efficiency during the submaximal work load significantly increased in group H, but not in group L. 5) DBP and MBP during the submaximal work load in group L significantly decreased compared with those before the training.	Oxygen	203-209	myelin basic protein	Homo sapiens	444-447
1956126-8	1991	SBP with a same oxygen-uptake load during submaximal work increased in group H, but decreased in group L. 6) Rate pressure products both at rest and during submaximal exercise decreased significantly in group L. 7) Serum lipid levels remained in all groups.	Oxygen	16-22	selenium binding protein 1	Homo sapiens	0-3
17212949-7	2007	Using the allele substitution effect model, the myostatin SNPs were found to have significant (P &lt; 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines.	Oxygen	152-158	myostatin	Gallus gallus	48-57
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	superoxide dismutase 2	Homo sapiens	17-23
1831462-0	1991	Kinetics of ATP release and Pi binding during the ATPase cycle of lethocerus flight muscle fibres, using phosphate-water oxygen exchange.	Oxygen	121-127	dynein axonemal heavy chain 8	Homo sapiens	50-56
1831462-1	1991	Rate constants have been obtained using oxygen isotope exchange techniques for steps controlling ATP release and Pi binding in the ATPase cycle of insect flight muscle fibres from the giant waterbug Lethecerus.	Oxygen	40-46	dynein axonemal heavy chain 8	Homo sapiens	131-137
1830495-0	1991	Oxygen regulation of uricase and sucrose synthase synthesis in soybean callus tissue is exerted at the mRNA level.	Oxygen	0-6	uricase-2 isozyme 1	Glycine max	21-28
1830495-3	1991	Quantitative mRNA hybridization experiments using nodule-specific uricase (Nodulin-35) and sucrose synthase (Nodulin-100) cDNA probes confirmed that the synthesis of the uricase and sucrose synthase is controlled by oxygen at the mRNA level.	Oxygen	216-222	uricase-2 isozyme 1	Glycine max	170-177
1830495-4	1991	The steady-state levels of uricase and sucrose synthase mRNA increased significantly (5-6- and 4-fold respectively) when the callus tissue was incubated at reduced oxygen concentration.	Oxygen	164-170	uricase-2 isozyme 1	Glycine max	27-34
34911033-9	2022	The corresponding V O2 for CS was 82.5 percentage of peak oxygen uptake and 81.3, 79.7, and 80.6 percentage of peak oxygen uptake for CPext, CPint, and CPtot, respectively.	Oxygen	20-22	citrate synthase	Homo sapiens	27-29
34911033-9	2022	The corresponding V O2 for CS was 82.5 percentage of peak oxygen uptake and 81.3, 79.7, and 80.6 percentage of peak oxygen uptake for CPext, CPint, and CPtot, respectively.	Oxygen	58-64	citrate synthase	Homo sapiens	27-29
34911033-11	2022	Nonetheless, the V O2 for CS and CPs were not statistically different (P = .09).	Oxygen	19-21	citrate synthase	Homo sapiens	26-28
34911033-13	2022	CONCLUSIONS: The systematic biases among V O2 at CS and CPint and CPtot were not clinically relevant.	Oxygen	43-45	citrate synthase	Homo sapiens	49-51
34943374-4	2021	This acute hypo-insulinemia may result from a disruption in chloride balance in beta-cells arising from an imbalanced KCC2-NKCC1 (chloride exporter-importer) density as a consequence of periodic oxygen desaturation.	Oxygen	195-201	solute carrier family 12 member 2	Rattus norvegicus	123-128
34943374-5	2021	Mechanistically, we postulate that a reduced insulin secretion due to the KCC2-NKCC1 imbalance subsequent to acute oxygen desaturation could result in hyperglycemia in rat pups, paralleling symptoms shown in patients with COVID-19 who experienced acute respiratory distress.	Oxygen	115-121	solute carrier family 12 member 2	Rattus norvegicus	79-84
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Oxygen	119-125	superoxide dismutase [Cu-Zn]	Bos taurus	48-70
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Oxygen	119-125	superoxide dismutase [Cu-Zn]	Bos taurus	72-76
16944313-7	2007	Therefore, immunohistochemical CA IX staining in human malignant glioma specimens can result from low oxygen concentrations or constitutive, oncogene-related, overexpression both of which may be prognostically relevant.	Oxygen	102-108	carbonic anhydrase 9	Homo sapiens	31-36
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Oxygen	127-129	superoxide dismutase [Cu-Zn]	Bos taurus	48-70
34941853-2	2021	To protect the cells from oxidative damage, the Superoxide dismutase-1 (SOD1) degraded the hydrogen peroxide (H2O2) to oxygen (O2) and water.	Oxygen	127-129	superoxide dismutase [Cu-Zn]	Bos taurus	72-76
1871781-4	1991	When the sulfates were hydrolyzed in 18O-water, the heavy-oxygen atom was shown to be incorporated quantitatively into the C-6 position of the products.	Oxygen	58-64	complement C6	Homo sapiens	123-126
1991071-1	1991	Exposure of adult rats to 85% ambient oxygen increased the content of surfactant proteins SP-A, SP-B, and SP-C recovered from alveolar lavage.	Oxygen	38-44	surfactant protein B	Rattus norvegicus	96-100
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	105-111	surfactant protein B	Rattus norvegicus	42-46
1991071-5	1991	The mRNAs encoding SP-A (1.7 and 1.0 kb), SP-B (1.6 kb), and SP-C (0.9 kb) increased significantly after oxygen exposure for 5 d. The present findings support the concept that oxygen exposure mediates surfactant protein expression at a pretranslational level.	Oxygen	176-182	surfactant protein B	Rattus norvegicus	42-46
34886825-7	2021	RESULTS: A higher renal mean (+-SD) regional tissue oxygen saturation (rSpO2) (76.7 (+-7.64)) was detected in the noPDA group than in the PDA (71.7 (+-9.02)) and hsPDA (67.4 (+-13.48)) groups (p < 0.001).	Oxygen	52-58	R-spondin 2	Rattus norvegicus	71-76
17191022-10	2007	The local increase in the PTHrP concentration was reduced when either oxygen or iloprost lowered the pressure.	Oxygen	70-76	parathyroid hormone like hormone	Homo sapiens	26-31
1648014-6	1991	We found that indirect spectrophotometric techniques based on superoxide dismutase (SOD)-inhibitable cytochrome c reduction for estimation of O2-., salicylate hydroxylation for OH.	Oxygen	142-144	cytochrome c	Oryctolagus cuniculus	101-113
17468822-16	2007	The improved immune function of PML due to the G-CSF treatment thus ameliorates the survival and the courses of sepsis, which is also defined by tissue perfusion and the cellular oxygen balance, which is affected by septic changes.	Oxygen	179-185	colony stimulating factor 3	Rattus norvegicus	47-52
1781304-7	1991	At P14 and P21, the calculated amount of oxygen used by the brain for the oxidation of ketone bodies was twice as high in barbiturate- as in saline-treated rats and reached values of 47 and 16% respectively in phenobarbital-exposed animals.	Oxygen	41-47	S100 calcium binding protein A9	Rattus norvegicus	3-6
1845766-8	1991	The elevation of inspired O2 was effective only if CBF increased once again above 150-200% of control, confirming that the critical CBF lies within this range of values.	Oxygen	26-28	CCAAT/enhancer binding protein zeta	Rattus norvegicus	51-54
17674820-3	2007	It has been demonstrated that electrons with this energy can dissociate water and oxygen molecules and produce various reactive radicals (*OH, H*, O*, HO2*), molecular species (H2O2, H2, O2), ultraviolet radiation and shock waves.	Oxygen	82-88	heme oxygenase 2	Homo sapiens	151-154
1845766-8	1991	The elevation of inspired O2 was effective only if CBF increased once again above 150-200% of control, confirming that the critical CBF lies within this range of values.	Oxygen	26-28	CCAAT/enhancer binding protein zeta	Rattus norvegicus	132-135
1845766-9	1991	We conclude that CBF must rise greater than 200% of control levels to provide sufficient O2 to meet the enhanced metabolic requirements of repetitive seizures.	Oxygen	89-91	CCAAT/enhancer binding protein zeta	Rattus norvegicus	17-20
1940652-3	1991	Using a simple theoretical approach it can be shown that oxygen transport capacity to the tissues is proportional to the radio H/eta s (where H = hematocrit, eta s = blood viscosity), as long as vascular bed geometry remains constant (with no sign of compensatory vasodilation).	Oxygen	57-63	endothelin receptor type A	Homo sapiens	129-132
1940652-3	1991	Using a simple theoretical approach it can be shown that oxygen transport capacity to the tissues is proportional to the radio H/eta s (where H = hematocrit, eta s = blood viscosity), as long as vascular bed geometry remains constant (with no sign of compensatory vasodilation).	Oxygen	57-63	endothelin receptor type A	Homo sapiens	158-161
2038069-1	1991	In the reoxygenated hypoxic heart, hypoxanthine is either oxidized by xanthine oxidase with production of toxic oxygen species or salvaged for the ATP pool by hypoxanthine-guanine phosphoribosyl transferase.	Oxygen	9-15	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	159-206
2085744-0	1990	High oxygen atmosphere for neuronal cell culture with nerve growth factor.	Oxygen	5-11	nerve growth factor	Rattus norvegicus	54-73
17244320-6	2007	Injection of FGF-2/CH-LA/IO4-heparin hydrogel into ischemic left lower limbs of rats also significantly recovered and increased blood flow and blood oxygen in the calf and thigh.	Oxygen	149-155	fibroblast growth factor 2	Rattus norvegicus	13-18
1964925-6	1990	These results reveal important features of the biological function of cSOD within the context of the overall oxygen defense system of Drosophila.	Oxygen	109-115	Superoxide dismutase 1	Drosophila melanogaster	70-74
17064313-3	2006	Recent studies have identified HO-2 as a potential oxygen sensor.	Oxygen	51-57	heme oxygenase 2	Homo sapiens	31-35
1700999-6	1990	On human monocytes we demonstrate that CD31 mAb recognizing certain epitopes of the CD31 molecule induce the generation of reactive oxygen metabolites.	Oxygen	132-138	platelet and endothelial cell adhesion molecule 1	Homo sapiens	39-43
1700999-6	1990	On human monocytes we demonstrate that CD31 mAb recognizing certain epitopes of the CD31 molecule induce the generation of reactive oxygen metabolites.	Oxygen	132-138	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-88
16899760-2	2006	Because Cygb shares several structural features with Mb, we hypothesized that Cygb functions in the modulation of oxygen and nitric oxide metabolism or in scavenging free radicals within a cell.	Oxygen	114-120	cytoglobin	Mus musculus	8-12
2165073-11	1990	The concomitant disruption of the AAC2 and AAC3, however, results in arrest of cell growth under conditions of low oxygen tension.	Oxygen	115-121	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	34-38
1970924-2	1990	In this study, ethanol, an agent that modulates peroxide metabolism by catalase and selectively inhibits the activation of guanylate cyclase by H2O2 but not by nitric oxide-related activators, was employed to further investigate the role of catalase in pulmonary arterial relaxation and guanylate cyclase activation by O2 and H2O2.	Oxygen	146-148	catalase	Bos taurus	71-79
16899760-2	2006	Because Cygb shares several structural features with Mb, we hypothesized that Cygb functions in the modulation of oxygen and nitric oxide metabolism or in scavenging free radicals within a cell.	Oxygen	114-120	cytoglobin	Mus musculus	78-82
16899760-7	2006	In contrast to Ngb, Cygb expression in the brain is induced in response to chronic hypoxia (10% oxygen).	Oxygen	96-102	cytoglobin	Mus musculus	20-24
2308037-5	1990	This increase in surfactant protein A content may reflect lung recovery from barotrauma and oxygen toxic effects or be a response to the primary pulmonary disease process.	Oxygen	92-98	surfactant protein A1	Homo sapiens	17-37
16899760-8	2006	These results support the hypothesis that Cygb is an oxygen-responsive tissue hemoglobin expressed in distinct regions of thenormoxic and hypoxic brain and may play a key role in the response of the brain to ahypoxic insult.	Oxygen	53-59	cytoglobin	Mus musculus	42-46
17125209-5	2006	Similarly, most UGT isoforms were found to have a statistically significant preference for oxygen over nitrogen as the nucleophilic atom.	Oxygen	91-97	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	16-19
2303446-13	1990	This result suggests that a major kinetic barrier for O2 and CO binding to native myoglobin may involve disruption of polar interactions between His64 and water molecules found in the distal pocket of deoxymyoglobin.	Oxygen	54-56	myoglobin	Physeter catodon	82-91
2294098-0	1990	Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity.	Oxygen	80-86	CD1c molecule	Homo sapiens	31-34
17132228-5	2006	Here, we demonstrate that oxygen-dependent recognition of HIFalpha by VHL triggers Rbx1-dependent neddylation of Cul2, which preferentially engages the E2 ubiquitin-conjugating enzyme UbcH5a.	Oxygen	26-32	von Hippel-Lindau tumor suppressor	Homo sapiens	70-73
17132228-5	2006	Here, we demonstrate that oxygen-dependent recognition of HIFalpha by VHL triggers Rbx1-dependent neddylation of Cul2, which preferentially engages the E2 ubiquitin-conjugating enzyme UbcH5a.	Oxygen	26-32	ubiquitin conjugating enzyme E2 D1	Homo sapiens	184-190
2117191-0	1990	Long-term oxygen therapy in patients with diagnoses other than COPD.	Oxygen	10-16	COPD	Homo sapiens	63-67
17077902-4	2006	The quantum yield of oxygen uptake (Phi(-O2)) increases with increasing donor concentration.	Oxygen	21-27	glucose-6-phosphate isomerase	Homo sapiens	36-39
2364809-10	1990	C in the reduction of the release of CPK-MB and MDA after open heart operation was attributed to its action as an oxygen free radical scavenger, thus decreasing the peroxidation of the lipids present in the cell membrane.	Oxygen	114-120	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	37-40
16520989-6	2006	RESULTS: Hypoxia (2% O2) induced 4-HPR resistance in the tested two ALL cell lines (Molt-4 and Molt-3), with at least a 2.8-fold increase in IC50 values (P&lt;0.01) compared with the IC50 values in normoxia (20% O2).	Oxygen	21-23	haptoglobin-related protein	Homo sapiens	35-38
6805528-1	1982	It was shown that coupling of the 2,3-DPH functional analog, pyridoxal-5"-phosphate (PP) to hemoglobin (Hb) and its polymer (HbP) enables one to obtain an artificial oxygen carrier with gas transport characteristics similar to those of freshly prepared donor"s blood.	Oxygen	166-172	heme binding protein 1	Homo sapiens	125-128
16520989-7	2006	Apoptotic detection showed that 2% O2 significantly suppressed 4-HPR-induced apoptosis and the percentages of 4-HPR-induced apoptotic cells at 12 and 24 h were 1.2 and 11.0%, respectively, compared with 12.6 and 76.3% in 20% O2.	Oxygen	35-37	haptoglobin-related protein	Homo sapiens	65-68
16520989-7	2006	Apoptotic detection showed that 2% O2 significantly suppressed 4-HPR-induced apoptosis and the percentages of 4-HPR-induced apoptotic cells at 12 and 24 h were 1.2 and 11.0%, respectively, compared with 12.6 and 76.3% in 20% O2.	Oxygen	35-37	haptoglobin-related protein	Homo sapiens	112-115
16520989-8	2006	In addition, in 20% O2, but not in 2% O2, 4-HPR obviously downregulated the protein expression of procaspase-3, ERK1/2 and XIAP, and increased the cleavage of PARP.	Oxygen	20-22	collagen type XI alpha 2 chain	Homo sapiens	159-163
17002676-9	2006	As such, the three prolyl hydroxylases (prolyl hydroxylase domain-containing protein (PHD) 1, PHD2 and PHD3) and the asparagyl hydroxylase (factor inhibiting HIF (FIH)-1) act as cellular oxygen sensors.	Oxygen	187-193	egl-9 family hypoxia inducible factor 2	Homo sapiens	40-92
33813068-10	2021	Thus, in the early phases of osteogenesis, MFN2 restrains oxygen consumption thereby limiting differentiation and cortical bone accrual during homeostasis in vivo.	Oxygen	58-64	mitofusin 2	Mus musculus	43-47
16616784-3	2006	Recently, a novel family of proteins (Nox1, 2 and 4) that act as the catalytic subunit of the superoxide (O2-) producing enzyme NADPH-oxidase has been discovered in vascular cells.	Oxygen	106-109	NADPH oxidase 1	Homo sapiens	38-51
33942365-9	2021	IL-35 and IL-37 levels were positively correlated with the apnea-hypopnea index (r = 0.742 and 0.578, respectively; both p < 0.001), while they were negatively correlated with the mean oxygen saturation (r = -0.461 and -0.339, respectively; both p < 0.001) and lowest oxyhaemoglobin saturation (r = -0.616 and -0.463, respectively; both p < 0.001) in patients with OSA.	Oxygen	185-191	interleukin 37	Homo sapiens	10-15
33034096-1	2021	In the anaerobic ammonium oxidation (anammox) process, the anammox bacterial activity is inhibited by high chemical oxygen demand (COD) contents.	Oxygen	116-122	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	131-134
33768186-10	2021	However, circulating levels of miR-181c and miR-484 on the 7th day showed significant positive correlations with the anaerobic threshold and peak oxygen consumption from CPET analysis.	Oxygen	146-152	microRNA 181c	Homo sapiens	31-39
33803527-2	2021	The purpose of the research was to study the effect of the relative oxygen concentration O2(x) = O2/(N2 + O2) in particular on adhesion, but also on the color, structural and mechanical properties of ZrON coatings synthesized by cathodic arc evaporation on HS6-5-2 steel substrates.	Oxygen	97-99	activity regulated cytoskeleton associated protein	Homo sapiens	23-26
16843828-9	2006	Pravastatin inhibited radical oxygen species production by inhibiting PKC delta.	Oxygen	30-36	protein kinase C delta	Homo sapiens	70-79
33800410-5	2021	We report that the CCNF that was produced by an oxygen-rich coal fragment from C6mimCl ionic liquid extraction showed the highest concentrations of quinone and ester groups on the surface.	Oxygen	48-54	cyclin F	Homo sapiens	19-23
16506218-5	2006	Further arguments for a putative role of VHL in NB are its function as oxygen sensitizer and the reported relation between hypoxia and dedifferentiation of NB cells, leading to a more aggressive phenotype.	Oxygen	71-77	von Hippel-Lindau tumor suppressor	Homo sapiens	41-44
16504517-4	2006	A comparison between the cytotoxicities of the title compound and 4,4-dimethyl-5,8-dihydroxynaphthalene-1-one, with their activities as inhibitors of oxygen uptake by the TA3-MTX-R cell line, is presented.	Oxygen	150-156	trace amine associated receptor 9	Homo sapiens	171-174
33801404-9	2021	We reveal transcriptome changes under swiss cheese knockdown in subperineurial glia and in cortex + wrapping glia and show that the downregulation of swiss cheese in these types of glia provokes reactive oxygen species acceleration.	Oxygen	204-210	swiss cheese	Drosophila melanogaster	38-50
33801404-9	2021	We reveal transcriptome changes under swiss cheese knockdown in subperineurial glia and in cortex + wrapping glia and show that the downregulation of swiss cheese in these types of glia provokes reactive oxygen species acceleration.	Oxygen	204-210	swiss cheese	Drosophila melanogaster	150-162
16504517-6	2006	The inhibition of oxygen uptake by TA3-MTX-R cells is useful as a quick test for preliminary screening of possible anticancer activity.	Oxygen	18-24	trace amine associated receptor 9	Homo sapiens	35-38
16509823-2	2006	Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF.	Oxygen	6-12	egl-9 family hypoxia inducible factor 2	Homo sapiens	51-55
16509823-2	2006	Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF.	Oxygen	6-12	egl-9 family hypoxia inducible factor 2	Homo sapiens	57-84
22723845-4	2012	Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS.	Oxygen	103-109	superoxide dismutase 2	Homo sapiens	0-22
22723845-4	2012	Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS.	Oxygen	103-109	superoxide dismutase 2	Homo sapiens	24-28
16509823-3	2006	In the presence of oxygen, they hydroxylate specific proline residues in HIF-alpha, allowing recognition by pVHL (von Hippel-Lindau protein) and subsequent ubiquitylation and proteasomal destruction.	Oxygen	19-25	von Hippel-Lindau tumor suppressor	Homo sapiens	108-112
16809770-3	2006	In the present study, we used mouse embryo fibroblasts nullizygous for HIF-1alpha or AMPK expression to show that AMPK is rapidly activated in vitro by both physiological and pathophysiological low-oxygen conditions, independently of HIF-1 activity.	Oxygen	198-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	114-118
16809770-4	2006	These findings imply that HIF-1 and AMPK are components of a concerted cellular response to maintain energy homeostasis in low-oxygen or ischemic-tissue microenvironments.	Oxygen	127-133	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-40
16565084-2	2006	These oxygen-sensitive modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family (PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of involvement of these and other enzymes of the same family in directing the global changes in gene expression that are induced by hypoxia.	Oxygen	6-12	egl-9 family hypoxia inducible factor 2	Homo sapiens	111-115
34862108-7	2022	Functions of cardiac muscle contraction, actin cytoskeleton and oxygen binding were significantly changed in the heart cells, which were involved in the altered expressions of tnni2a.4, acta1a, atp1a1a.2, mylpfa, and so on.	Oxygen	64-70	troponin I type 2a (skeletal, fast), tandem duplicate 4	Danio rerio	176-184
34862108-7	2022	Functions of cardiac muscle contraction, actin cytoskeleton and oxygen binding were significantly changed in the heart cells, which were involved in the altered expressions of tnni2a.4, acta1a, atp1a1a.2, mylpfa, and so on.	Oxygen	64-70	actin alpha 1, skeletal muscle a	Danio rerio	186-192
34862108-7	2022	Functions of cardiac muscle contraction, actin cytoskeleton and oxygen binding were significantly changed in the heart cells, which were involved in the altered expressions of tnni2a.4, acta1a, atp1a1a.2, mylpfa, and so on.	Oxygen	64-70	myosin light chain, phosphorylatable, fast skeletal muscle a	Danio rerio	205-211
34944684-4	2021	For this, an oxygen electrode-based method was employed to determine the catalase activity and the apparent kinetic parameters for purified catalase, as well as catalase naturally present in HaCaT keratinocytes, excised stratum corneum samples collected from pig ears with various amounts of melanin, and defatted algae biomass from the diatom Phaeodactylum tricornutum.	Oxygen	13-19	catalase	Sus scrofa	73-81
34944684-4	2021	For this, an oxygen electrode-based method was employed to determine the catalase activity and the apparent kinetic parameters for purified catalase, as well as catalase naturally present in HaCaT keratinocytes, excised stratum corneum samples collected from pig ears with various amounts of melanin, and defatted algae biomass from the diatom Phaeodactylum tricornutum.	Oxygen	13-19	catalase	Sus scrofa	140-148
34944684-5	2021	Taken together, this work illustrates the versatility of the oxygen electrode-based method for characterizing catalase function in samples with a high degree of complexity and enables the assessment of sample treatment protocols and comparisons between different biological systems related to the skin organ or algae-derived materials as a potential source of skin care ingredients for combating oxidative stress.	Oxygen	61-67	catalase	Sus scrofa	110-118
16709914-2	2006	Respiratory proteins like hemoglobin or myoglobin bind or store oxygen, thus enhancing its availability to the respiratory chain in the mitochondria.	Oxygen	64-70	myoglobin	Danio rerio	40-49
34944680-4	2021	We found that maximal oxygen consumption rates, but not the rates of acidification and proton leak, were increased in islets after acute NOX4 inhibition.	Oxygen	22-28	NADPH oxidase 4	Homo sapiens	137-141
34879781-6	2021	The effects of acaricide on myoglobin and periostin, which are associated with oxygen transport and muscle regeneration, respectively, were investigated at the gene and protein levels.	Oxygen	79-85	myoglobin	Danio rerio	28-37
34879781-6	2021	The effects of acaricide on myoglobin and periostin, which are associated with oxygen transport and muscle regeneration, respectively, were investigated at the gene and protein levels.	Oxygen	79-85	periostin, osteoblast specific factor b	Danio rerio	42-51
34600384-6	2022	The oxidation of Cr3+ to Cr6+ in the presence of alkaline substances has been elucidated by density functional theory, and it is revealed that the electrons from the Cr-d orbit jump to the Ca-d and directly transform into the O2.	Oxygen	226-228	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	17-20
34878944-2	2022	Previous studies indicate that TGFbeta activation in the O2-injured mouse pup lung increases lysyl oxidase (LOX) expression.	Oxygen	57-59	lysyl oxidase	Mus musculus	108-111
34878944-4	2022	First, we determined that O2-mediated lung injury increases LOX protein expression in TGFbeta-stimulated pup lung interstitial fibroblasts.	Oxygen	26-28	lysyl oxidase	Mus musculus	60-63
34878944-9	2022	Also, O2-mediated injury was determined to increase pro-LOX secretion and nuclear LOX immunoreactivity particularly in areas populated with interstitial fibroblasts and exhibiting malformed ECM.	Oxygen	6-8	lysyl oxidase	Mus musculus	56-59
16709914-7	2006	Myoglobin mRNA and protein in heart mildly increased, in line with its proposed oxygen supply function.	Oxygen	80-86	myoglobin	Danio rerio	0-9
34878944-9	2022	Also, O2-mediated injury was determined to increase pro-LOX secretion and nuclear LOX immunoreactivity particularly in areas populated with interstitial fibroblasts and exhibiting malformed ECM.	Oxygen	6-8	lysyl oxidase	Mus musculus	82-85
34863290-10	2021	Finally, the knockdown of LUCAT1 prevented e-cig-induced EC dysfunction by maintaining  vascular barrier, reducing reactive oxygen species level, and increasing migration capacity.	Oxygen	124-130	lung cancer associated transcript 1	Homo sapiens	26-32
16709914-9	2006	This observation, firstly, suggests physiological differences of zebrafish eye and brain under hypoxia, and secondly, indicates an important role of neuroglobin in oxidative metabolism, probably oxygen supply within neurons.	Oxygen	195-201	neuroglobin	Danio rerio	149-160
34878944-10	2022	Then, using molecular probes, we detected increased aldehyde levels in vivo in O2-injured pup lungs, which mapped to areas of increased pro-LOX secretion in lung sections.	Oxygen	79-81	lysyl oxidase	Mus musculus	140-143
16554353-0	2006	Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production.	Oxygen	133-139	mitogen activated protein kinase 3	Rattus norvegicus	158-164
34728328-8	2022	The high-pressure sensitive sod1 mutants were also susceptible to sublethal levels of the O2 - generator paraquat.	Oxygen	90-92	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	28-32
34273469-4	2021	Cancer cells are chronically exposed to various stresses, such as lack of oxygen and nutrients, immune responses, dysregulated metabolism and genomic instability, all of which lead to the activation of heat shock factor 1 (HSF1).	Oxygen	74-80	heat shock transcription factor 1	Homo sapiens	202-221
34273469-4	2021	Cancer cells are chronically exposed to various stresses, such as lack of oxygen and nutrients, immune responses, dysregulated metabolism and genomic instability, all of which lead to the activation of heat shock factor 1 (HSF1).	Oxygen	74-80	heat shock transcription factor 1	Homo sapiens	223-227
34728328-12	2022	Taken these results together, we suggest that high pressure enhances O2 - production and Sod1 within the IMS plays a role in scavenging O2 - allowing the cells to grow under high pressure.	Oxygen	136-140	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	89-93
16528751-0	2006	Bone marrow stromal cells induce BMP2/4 production in oxygen-glucose-deprived astrocytes, which promotes an astrocytic phenotype in adult subventricular progenitor cells.	Oxygen	54-60	bone morphogenetic protein 2	Homo sapiens	33-39
34583038-6	2022	Combining relevant spectroscopic results and HRTEM images, we revealed that the excellent cyclability of Li1.25Mn0.25Ti0.5O1.75F0.25 is rooted in the weakened adverse effects of moderated oxygen redox and the reduced Jahn-Teller distortion effect resulting from Mn3+, endowing the fluoridized DRX with better structural stability and larger Mn2+/Mn4+ reservoir.	Oxygen	188-194	transglutaminase 1	Homo sapiens	105-108
34517118-10	2021	Patients with SDB had significantly lower atrial Cx43 expression, which was negatively correlated with AHI and oxygen-desaturation-index.	Oxygen	111-117	gap junction protein alpha 1	Homo sapiens	49-53
16722699-7	2006	The rate constant of the reaction CH3C(O)CHOH + O2 --&gt; CH3C(O)CHO + HO2 at 298 K, (3.0 +/- 0.6) x 10(-12) cm3 molecule(-1) s(-1), was estimated by computer simulation of the concentration-time profiles of the CH3C(O)CHO product.	Oxygen	48-50	heme oxygenase 2	Homo sapiens	71-74
34545968-2	2021	Our previous study showed that AGE-induced reactive oxygen species-dependent apoptosis is mediated via protein kinase C delta (PKCdelta)-enhanced mitochondrial damage in cardiomyocytes.	Oxygen	52-58	protein kinase C delta	Homo sapiens	103-125
34718179-3	2022	Herein, to overcome tumor-associated hypoxia, and further achieve tumor-targeted synergistic chemotherapy/PDT/photothermal therapy (PTT), we have constructed a biodegradable oxygen-producing nanoplatform (named Ini@PM-HP), which was composed of the porous metal-organic framework (PCN-224(Mn)), the poly (ADP-ribose) polymerase (PARP) inhibitor (Iniparib), and the polydopamine-modified hyaluronic acid (HA-PDA).	Oxygen	174-180	PHD finger protein 5A	Homo sapiens	211-214
34718179-10	2022	STATEMENT OF SIGNIFICANCE: A delicately designed biodegradable oxygen-producing nanoplatform Ini@PM-HP is constructed to achieve combination therapy of solid tumors.	Oxygen	63-69	PHD finger protein 5A	Homo sapiens	93-96
34545968-2	2021	Our previous study showed that AGE-induced reactive oxygen species-dependent apoptosis is mediated via protein kinase C delta (PKCdelta)-enhanced mitochondrial damage in cardiomyocytes.	Oxygen	52-58	protein kinase C delta	Homo sapiens	127-135
16599438-6	2006	The topological analysis of the distribution of the charge density (AIM theory) confirmed the existence of the hydrogen bond in I-1, I-2 complexes and indicated weak interaction between the oxygen atom of CH(3)OH and three fluorine atoms of CF(4) in the I-3 complex.	Oxygen	190-196	brain protein I3	Homo sapiens	254-257
34677911-5	2021	This work provides the possibilities for skillfully regulating oxygen vacancy and meantime enhancing Li2 O reversibility.	Oxygen	63-69	ATP binding cassette subfamily A member 12	Homo sapiens	101-104
34610470-0	2022	PLD1 Promotes Reactive Oxygen Species Production in Vascular Smooth Muscle Cells and Injury-Induced Neointima Formation.	Oxygen	23-29	phospholipase D1	Mus musculus	0-4
16562948-8	2006	Notably, the structure with alpha-D-Fru-1,6-P2 demonstrated the presence of a strong hydrogen bond between the C2 hydroxyl group and the C1 phosphate oxygen atom, which may support the previously proposed catalytic mechanism in the active site of fructose-1,6-bisphosphatase.	Oxygen	150-156	zinc finger and BTB domain containing 22	Homo sapiens	36-39
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	jun proto-oncogene	Mus musculus	169-173
34401997-9	2022	In vitro, Zeb2/Axin2-enriched exosomes significantly increased neurite branching and elongation of cultured cortical embryonic rat neurons under oxygen- and glucose-deprived (OGD) conditions.	Oxygen	145-151	axin 2	Rattus norvegicus	15-20
34965440-5	2021	Thus, KSHV regulation of the oxygen-sensing machinery allows virally infected cells to initiate translation via the mTOR-dependent eIF4E1 or the HIF2alpha-dependent, mTOR-independent, eIF4E2.	Oxygen	29-35	eukaryotic translation initiation factor 4E	Homo sapiens	131-137
34844041-7	2021	The inhibition of XOR activity appears more promising than just the control of uricemia level in preventing cardiovascular events, possibly because it also reduces the intracellular accumulation of urate, as well as the production of reactive oxygen species.	Oxygen	243-249	xanthine dehydrogenase	Homo sapiens	18-21
34856430-6	2021	A new conversion mechanism was proposed that CN- was activated into electron-deficient cyanide radical ( CN) by  OH, and then the  CN intermediates reacted with  O2- via nucleophilic addition to quickly form NO3-, preventing the formation of CNO- and promoting the mineralization of cyanide.	Oxygen	162-165	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	242-245
16019190-0	2006	NOX4 as an oxygen sensor to regulate TASK-1 activity.	Oxygen	11-17	NADPH oxidase 4	Homo sapiens	0-4
34901882-0	2021	Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity.	Oxygen	94-100	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	23-48
34901882-0	2021	Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity.	Oxygen	94-100	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	50-53
34901882-2	2021	sGC is a heterodimer, composed of an alpha1 and a beta1 subunit, of which the latter contains the heme-nitric oxide/oxygen (H-NOX) domain, responsible for NO recognition, binding and signal initiation.	Oxygen	116-122	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	0-3
34939230-6	2022	Consistent with these results, the basal and ATP-linked oxygen consumption rates were significantly increased by FoxQ1 overexpression in SUM159 and luminal-type MCF-7 cells.	Oxygen	56-62	forkhead box Q1	Homo sapiens	113-118
16019190-5	2006	In the present study, we propose that the NADPH oxidase NOX4 functions as an oxygen-sensing partner and that it modulates the oxygen sensitivity of TASK-1.	Oxygen	77-83	NADPH oxidase 4	Homo sapiens	56-60
34500227-3	2021	The deposited CuX converts to CunO, leading to the generation of abundant oxygen vacancies in the CuO lattice, enhancing the number of catalytically active sites, and improving the charge transfer efficiency.	Oxygen	74-80	cut like homeobox 1	Homo sapiens	14-17
34739656-0	2022	CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p.	Oxygen	35-41	DLG associated protein 4	Homo sapiens	0-10
16019190-5	2006	In the present study, we propose that the NADPH oxidase NOX4 functions as an oxygen-sensing partner and that it modulates the oxygen sensitivity of TASK-1.	Oxygen	126-132	NADPH oxidase 4	Homo sapiens	56-60
16019190-7	2006	In HEK293 cells expressing NOX4 endogenously, the activity of expressed TASK-1 was moderately inhibited by hypoxia, and this oxygen response was significantly augmented by NOX4.	Oxygen	125-131	NADPH oxidase 4	Homo sapiens	27-31
34494136-12	2021	In VIC cultures treated with glucose in combination with reactive oxygen species (ROS) inhibitor (N-acetyl-L-cysteine), the expression of NF-kappaB and BMP-2 was significantly suppressed.	Oxygen	66-72	bone morphogenetic protein 2	Homo sapiens	152-157
16019190-7	2006	In HEK293 cells expressing NOX4 endogenously, the activity of expressed TASK-1 was moderately inhibited by hypoxia, and this oxygen response was significantly augmented by NOX4.	Oxygen	125-131	NADPH oxidase 4	Homo sapiens	172-176
34876189-9	2021	The activity of fat metabolism-related enzymes, ATGL, HSL, and MGL increased under hypothermia and low oxygen conditions.	Oxygen	103-109	lipase E, hormone sensitive type	Rattus norvegicus	54-57
16019190-8	2006	Moreover, the oxygen sensitivity of TASK-1 was abolished by NOX4 siRNA and NADPH oxidase inhibitors.	Oxygen	14-20	NADPH oxidase 4	Homo sapiens	60-64
16019190-9	2006	These results suggest a novel function for NOX4 in the oxygen-dependent regulation of TASK-1 activity.	Oxygen	55-61	NADPH oxidase 4	Homo sapiens	43-47
16581766-0	2006	Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms.	Oxygen	22-28	surfactant protein A1	Homo sapiens	76-96
34431623-1	2021	The von Hippel-Lindau tumor suppressor protein (pVHL) is involved in maintaining the cellular oxygen homeostasis through the regulated degradation of HIF-alpha.	Oxygen	94-100	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
34523745-0	2021	Hyperbaric Oxygen via Mediating SIRT1-Induced Deacetylation of HMGB1 Improved Cerebral Ischemia/Reperfusion injury.	Oxygen	11-17	high mobility group box 1	Mus musculus	63-68
16540390-1	2006	Xanthine oxidoreductase (XOR) activity has been previously noted to be responsive to changes in O2 tension.	Oxygen	96-98	xanthine dehydrogenase	Homo sapiens	0-23
34237174-2	2021	Increased arginase 1 activity leads to reduced nitric oxide (NO) production and increased formation of reactive oxygen species due to uncoupling of the NO-producing enzyme endothelial NO synthase (eNOS).	Oxygen	112-118	arginase 1	Homo sapiens	10-20
34661337-8	2021	Tet2/3 cooperatively induces Prdm1 expression via oxygen-dependent DNA demethylation, which in turn activates NFATc1 required for osteoclastogenesis.	Oxygen	50-56	PR domain containing 1, with ZNF domain	Mus musculus	29-34
16540390-1	2006	Xanthine oxidoreductase (XOR) activity has been previously noted to be responsive to changes in O2 tension.	Oxygen	96-98	xanthine dehydrogenase	Homo sapiens	25-28
34583309-1	2021	TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator (TIGAR) belongs to the phosphatases family of proteins that modulates the level of reactive oxygen species in tumor cells.	Oxygen	159-165	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	68-73
16540390-2	2006	While prior studies have focused on the extremes (0-3% and 95-100%) of O2 tensions, we report the influence of 10% O2 on endothelial cell XOR, a concentration resembling modest arterial hypoxia commonly found in patients with chronic cardiopulmonary diseases.	Oxygen	115-117	xanthine dehydrogenase	Homo sapiens	138-141
34569192-0	2021	Construction of pH-Dependent Nanozymes with Oxygen Vacancies as the High-Efficient Reactive Oxygen Species Scavenger for Oral-Administrated Anti-Inflammatory Therapy.	Oxygen	44-50	phenylalanine hydroxylase	Homo sapiens	16-18
16368716-6	2006	Intravitreal injection of PEDF significantly reduced vascular hyper-permeability in rat models of diabetes and oxygen-induced retinopathy, correlating with the decreased levels of retinal inflammatory factors, including VEGF, VEGF receptor-2, MCP-1, TNF-alpha, and ICAM-1.	Oxygen	111-117	serpin family F member 1	Rattus norvegicus	26-30
34506261-0	2021	Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.	Oxygen	24-30	programmed cell death 4	Homo sapiens	80-85
34656824-10	2021	Notably, Cyb5r3 knockdown HAECs showed less total H2O2 but more mitochondrial O2 -.	Oxygen	78-82	cytochrome b5 reductase 3	Homo sapiens	9-15
34677913-7	2021	Therefore, the stable Ca4.67 Li0.33 (PO4 )3 F and CaF2 layers play a pivotal role to protect the Li(Ni0.8 Co0.15 Al0.05 )O2 with ultra-long cycling stability.	Oxygen	121-123	carbonic anhydrase 4	Homo sapiens	22-25
34677913-7	2021	Therefore, the stable Ca4.67 Li0.33 (PO4 )3 F and CaF2 layers play a pivotal role to protect the Li(Ni0.8 Co0.15 Al0.05 )O2 with ultra-long cycling stability.	Oxygen	121-123	CCR4-NOT transcription complex subunit 8	Homo sapiens	50-54
34832065-6	2021	Mitochondria isolated from ANT1-TG hearts experienced less restricted oxygen consumption than WT mitochondria after I/R.	Oxygen	70-76	solute carrier family 25 member 4	Rattus norvegicus	27-31
34954904-7	2021	CEBPD promoted glucose uptake and lactate production by upregulating SLC2A1 and HK2, leading to mitochondrial fission, increased extracellular acidification rate and decreased oxygen consumption rate to fuel cell growth.	Oxygen	176-182	hexokinase 2	Homo sapiens	80-83
16440060-3	2006	Rather than improving energy balance, the genetic replacement of pituitary POMC in PomcTg mice aggravated their metabolic syndrome with increased caloric intake and feed efficiency, reduced oxygen consumption, increased subcutaneous, visceral, and hepatic fat, and severe insulin resistance.	Oxygen	190-196	pro-opiomelanocortin-alpha	Mus musculus	75-79
34396536-2	2021	In this study, the mechanism by which the interleukin (IL)-23/IL-17 axis regulates RNV in oxygen-induced retinopathy (OIR) model mice and in cell experiments in vitro was characterized.	Oxygen	90-96	interleukin 23, alpha subunit p19	Mus musculus	42-61
34643624-1	2021	A Ni-based MOF is in situ grown onto Ni(OH)2 nanosheets to effectively suppress the oxygen evolution reaction for the efficient electrocatalytic oxidation of biomass-derived 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid with 100% yield and faradaic efficiency at 1.4 V (vs. RHE).	Oxygen	84-90	factor interacting with PAPOLA and CPSF1	Homo sapiens	282-285
34643202-2	2021	The lattice contraction of co-precipitated BaM nanoparticles is detected after prolonged sintering at 900  C. In addition, investigation with X-ray photoelectron spectroscopy (XPS) provides evidence of a highly enhanced population of oxygen vacancies.	Oxygen	234-240	structural maintenance of chromosomes 3	Homo sapiens	43-46
34643202-3	2021	The lattice distortion and formation of oxygen vacancies are attributed to a direct result of substitutional incorporation of smaller Na ions into Ba2+ sites in the lattice of BaM during prolonged annealing.	Oxygen	40-46	structural maintenance of chromosomes 3	Homo sapiens	176-179
34643202-6	2021	Minimization of the magnon peak is also identified after prolonged annealing, which indicates oxygen vacancy-induced collapse of strong anti-ferromagnetic interaction between Fe3+ ions in the bipyramidal sites and the octahedral sites in BaM nanoparticles.	Oxygen	94-100	structural maintenance of chromosomes 3	Homo sapiens	238-241
34229824-5	2021	MTO-1 revealed an overpotential () = 1.329 V and Tafel slope (b) = 374 mV/dec towards Oxygen Evolution Reaction (OER) electrocatalyst and exhibited = 0.914 V and b = 301.4 mV/dec towards Hydrogen Evolution Reaction (HER) electrocatalyst, both in presence of alkaline 1 M KOH solution, making these MgTiO3 nanoparticles very promising for potential use in various technologically important electrochemical applications.	Oxygen	86-92	mitochondrial tRNA translation optimization 1	Homo sapiens	0-5
16338960-3	2006	Concomitant with the O2 uptake, both ascorbate peroxidase (APX) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) lost their activities.	Oxygen	21-23	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	37-57
34599743-5	2021	Our results show that SARS- COV2 spike protein increases the levels of pro-inflammatory cytokines and ROS production, increases apoptosis and increases the oxygen consumption rate (OCR) in microglial cells.	Oxygen	156-162	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	33-38
34388291-8	2021	We suggest that ERK-mediated phosphorylation of HIF-1alpha regulates its physical interaction with NPM1, which is essential for productive association of HIF-1 with hypoxia target genes and their optimal transcriptional activation, required for survival under low oxygen or tumor growth.	Oxygen	264-270	nucleophosmin 1	Homo sapiens	99-103
34371008-4	2021	High glucose concentrations stimulated reactive oxygen species production through NADPH oxidase activation, decreased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and reduced deacetylase sirtuin 1 (SIRT1) protein levels and activity.	Oxygen	48-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	118-166
34371008-4	2021	High glucose concentrations stimulated reactive oxygen species production through NADPH oxidase activation, decreased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and reduced deacetylase sirtuin 1 (SIRT1) protein levels and activity.	Oxygen	48-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	168-172
34692172-3	2022	Specifically, the Pr3+ substitution in LCGO is beneficial to activating defect site reconstruction including the generation of cation defects and the decrease of oxygen vacancies.	Oxygen	162-168	proteinase 3	Homo sapiens	18-21
16338960-3	2006	Concomitant with the O2 uptake, both ascorbate peroxidase (APX) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) lost their activities.	Oxygen	21-23	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	59-62
34583010-6	2021	TGF-beta1 alters gene expression programs in white adipocytes, favoring their fatty acid oxidation and consequently increasing their mitochondrial oxygen consumption rates.	Oxygen	147-153	transforming growth factor, beta 1	Mus musculus	0-9
16338960-3	2006	Concomitant with the O2 uptake, both ascorbate peroxidase (APX) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) lost their activities.	Oxygen	21-23	glyceraldehyde-3-phosphate dehydrogenase, cytosolic	Nicotiana tabacum	68-108
16338960-3	2006	Concomitant with the O2 uptake, both ascorbate peroxidase (APX) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) lost their activities.	Oxygen	21-23	glyceraldehyde-3-phosphate dehydrogenase, cytosolic	Nicotiana tabacum	110-115
34943874-4	2021	The high Ngb levels (~100-200 muM) present in the retinal ganglion cell layer and in the optic nerve facilitate the O2 buffer and delivery.	Oxygen	116-118	neuroglobin	Mus musculus	9-12
34648132-6	2021	Furthermore, a lack of miR-7-5p expression led to increased levels of transferrin receptor, promoting the uptake of iron and production of lipid reactive oxygen species and demonstrating that DOX-induced ferroptosis occurs in AC16 cells.	Oxygen	154-160	transferrin receptor	Homo sapiens	70-90
16430787-0	2006	Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo.	Oxygen	35-41	myoglobin	Rattus norvegicus	25-34
34943874-5	2021	In contrast, the very low levels of Ngb (~1 muM) in most tissues and organs support (pseudo-)enzymatic properties including NO/O2 metabolism, peroxynitrite and free radical scavenging, nitrite, hydroxylamine, hydrogen sulfide reduction, and the nitration of aromatic compounds.	Oxygen	127-129	neuroglobin	Mus musculus	36-39
16430787-1	2006	BACKGROUND: Myoglobin (Mb) is the simplest monomeric hemoprotein and its physicochemical properties including reversible oxygen (O2)binding in aqueous solution are well known.	Oxygen	121-127	myoglobin	Rattus norvegicus	12-21
34494990-0	2021	Hyperbaric oxygen therapy improves neurological function via the p38-MAPK/CCL2 signaling pathway following traumatic brain injury.	Oxygen	11-17	mitogen activated protein kinase 14	Rattus norvegicus	65-73
16430787-1	2006	BACKGROUND: Myoglobin (Mb) is the simplest monomeric hemoprotein and its physicochemical properties including reversible oxygen (O2)binding in aqueous solution are well known.	Oxygen	121-127	myoglobin	Rattus norvegicus	23-25
34690806-0	2021	Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis.	Oxygen	95-101	citrate synthase	Homo sapiens	0-15
34685639-6	2021	Cardiac fibroblasts exposed to high glucose produced increased amounts of the receptor for advanced glycation end products, reactive oxygen species and inflammatory cytokines, all of which were prevented by SP.	Oxygen	133-139	trefoil factor 2 (spasmolytic protein 1)	Mus musculus	207-209
34461100-4	2021	In Pstpip2cmo mice, overproduction of IL-1beta and reactive oxygen species by neutrophil granulocytes leads to spontaneous inflammation of the bones and surrounding soft tissues.	Oxygen	60-66	proline-serine-threonine phosphatase-interacting protein 2	Mus musculus	3-10
34885506-5	2021	The reactivity of surface oxygen species and their amounts were determined by H2-TPR, TGA-DTG, the oxidation state of surface oxygen ions by XPS.	Oxygen	26-32	T-box transcription factor 1	Homo sapiens	86-89
34855654-10	2022	Concurrently, BNP at discharge was correlated with age, central DBP (cDBP), urea, creatinine, LVEDD, partial oxygen pressure (pO2), and oxygen saturation (SO2).	Oxygen	109-115	natriuretic peptide B	Homo sapiens	14-17
34855654-10	2022	Concurrently, BNP at discharge was correlated with age, central DBP (cDBP), urea, creatinine, LVEDD, partial oxygen pressure (pO2), and oxygen saturation (SO2).	Oxygen	136-142	natriuretic peptide B	Homo sapiens	14-17
34873439-6	2021	The model of blood-brain barrier was established by culturing brain microvascular endothelial cells and pericytes in vitro, and the changes of miR-539 expression level and permeability after glucose and oxygen deprivation were detected.	Oxygen	203-209	microRNA 539	Rattus norvegicus	143-150
16430787-1	2006	BACKGROUND: Myoglobin (Mb) is the simplest monomeric hemoprotein and its physicochemical properties including reversible oxygen (O2)binding in aqueous solution are well known.	Oxygen	129-131	myoglobin	Rattus norvegicus	12-21
34873439-9	2021	Glucose and oxygen deprivation treatment in brain microvascular endothelial cells can lead to downregulation of miR-539 expression and affect cell permeability.	Oxygen	12-18	microRNA 539	Rattus norvegicus	112-119
16430787-1	2006	BACKGROUND: Myoglobin (Mb) is the simplest monomeric hemoprotein and its physicochemical properties including reversible oxygen (O2)binding in aqueous solution are well known.	Oxygen	129-131	myoglobin	Rattus norvegicus	23-25
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	168-171
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	169-172
34196122-6	2021	TGA exemption was obtained for 98% oxygen and 2% carbon dioxide carbogen gas mixture and delivery apparatus for each patient.	Oxygen	35-41	T-box transcription factor 1	Homo sapiens	0-3
16430787-9	2006	RESULTS: The O2 dissociation curve (ODC) of Mb, when the effluent buffer O2 pressure was used as the abscissa, was of a sigmoid shape under normal and increased respiratory conditions whereas it was of rectangular hyperbolic shape under a suppressed respiratory condition.	Oxygen	13-15	myoglobin	Rattus norvegicus	44-46
16683710-0	2006	In search of the acute oxygen sensor: functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2.	Oxygen	23-29	heme oxygenase 2	Homo sapiens	143-158
34338972-0	2021	Long non-coding RNA Gm11974 aggravates oxygen-glucose deprivation-induced injury via miR-122-5p/SEMA3A axis in ischaemic stroke.	Oxygen	39-45	small nucleolar RNA host gene 15	Mus musculus	20-27
34818535-3	2021	DUSP6 mutation in Caco-2 cells enhances the epithelial feature and increases mitochondrial oxygen consumption, accompanied by altered glucose metabolism and decreased glycolysis.	Oxygen	91-97	dual specificity phosphatase 6	Homo sapiens	0-5
16987804-0	2006	The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants.	Oxygen	78-84	Janus kinase 2	Homo sapiens	4-8
34829959-4	2021	Three XOR inhibitors are currently used as hyperuricemia and gout therapeutics but are also expected to have potential effects other than uric acid reduction, such as suppressing XO-generating reactive oxygen species.	Oxygen	202-208	xanthine dehydrogenase	Homo sapiens	6-9
34718730-0	2021	Editorial Expression of Concern on "Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP".	Oxygen	86-92	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	50-54
34718730-0	2021	Editorial Expression of Concern on "Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP".	Oxygen	86-92	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	55-60
34191305-6	2021	We found evidence suggesting that exposing plants to red light increases levels of salicylic acid (SA) and induces SA signalling mediating the production of reactive oxygen species, with substantial differences between species and plant organs.	Oxygen	166-172	acyl-CoA synthetase medium chain family member 3	Homo sapiens	115-117
34587716-0	2021	Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis.	Oxygen	56-62	glutathione peroxidase 4	Rattus norvegicus	188-192
16987804-2	2006	We tested 22 patients with high oxygen affinity beta chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera.	Oxygen	32-38	Janus kinase 2	Homo sapiens	92-96
16374519-4	2006	Consistent with these microarray data, RIP140 gene silencing in cultured adipocytes increased both conversion of [14C]glucose to CO2 and mitochondrial oxygen consumption.	Oxygen	151-157	nuclear receptor interacting protein 1	Mus musculus	39-45
34482701-0	2021	Pericardial Adipose Tissue-Derived Leptin Promotes Myocardial Apoptosis in High-Fat Diet-Induced Obese Rats Through Janus Kinase 2/Reactive Oxygen Species/Na+/K+-ATPase Signaling Pathway.	Oxygen	140-146	leptin	Rattus norvegicus	35-41
34482701-9	2021	Moreover, leptin derived from PAT of obese rats inhibited Na+/K+-ATPase activity of H9c2 cells through stimulating reactive oxygen species, thereby activating calcium-dependent apoptosis.	Oxygen	124-130	leptin	Rattus norvegicus	10-16
34545102-3	2021	When the (AX) sublayer has a net charge, for example (LaO)+ in LaCoO3 and LaNiO3, substantial tetragonal elongation of oxygen octahedra at the fault plane is observed and this screens the strong repulsion between the consecutive (LaO)+ layers.	Oxygen	119-125	interleukin 4 induced 1	Homo sapiens	54-57
34734688-5	2021	An obvious decrease in the surface-adsorbed oxygen content based on the X-ray photoelectron spectroscopy measurement further confirmed that light illumination was helpful to clear the surface of SnS2/TiO2 and thus increased active sites for NO2 sensing.	Oxygen	44-50	sodium voltage-gated channel alpha subunit 11	Homo sapiens	195-199
16997902-1	2006	Ascorbate oxidase (AO) is a cell wall-localized enzyme that uses oxygen to catalyse the oxidation of ascorbate (AA) to the unstable radical monodehydroascorbate (MDHA) which rapidly disproportionates to yield dehydroascorbate (DHA) and AA, and thus contributes to the regulation of the AA redox state.	Oxygen	65-71	L-ascorbate oxidase-like	Nicotiana tabacum	0-17
34699202-3	2021	PIP4K2A/B depletion has been shown to induce tumor growth inhibition, possibly due to hyperactivation of AKT and reactive oxygen species-mediated apoptosis.	Oxygen	122-128	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	Homo sapiens	0-9
34537235-0	2021	HIF-1alpha hydroxyprolines modulate oxygen-dependent protein stability via single VHL interface with comparable effect on ubiquitination rate.	Oxygen	36-42	von Hippel-Lindau tumor suppressor	Homo sapiens	82-85
34537235-2	2021	The principal step in this critical cellular process is the hydroxylation of either or both of the two conserved proline residues P402 and P564 within the oxygen-dependent degradation domain (ODD) of HIF-1alpha subunit via prolyl hydroxylases, which is necessary for binding VHL.	Oxygen	155-161	von Hippel-Lindau tumor suppressor	Homo sapiens	275-278
34662099-12	2021	The observed switch in substrate specificity of the enzyme is consistent with this result if the hydrogen bonding to the proximal peroxo oxygen is necessary for a proposed nucleophilic peroxoanion-mediated mechanism for CYP17A1 in carbon-carbon bond scission.	Oxygen	137-143	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	220-227
34383048-10	2021	Blocking noncanonical PKM2 activity also increased lactate excretion (1.2-1.6-fold, P < 0.05) and suppressed mitochondrial oxygen consumption (1.3-1.6-fold, P < 0.01).	Oxygen	123-129	pyruvate kinase, muscle	Mus musculus	22-26
34545102-3	2021	When the (AX) sublayer has a net charge, for example (LaO)+ in LaCoO3 and LaNiO3, substantial tetragonal elongation of oxygen octahedra at the fault plane is observed and this screens the strong repulsion between the consecutive (LaO)+ layers.	Oxygen	119-125	interleukin 4 induced 1	Homo sapiens	230-233
34567109-0	2021	Growth Hormone (GH) Enhances Endogenous Mechanisms of Neuroprotection and Neuroplasticity after Oxygen and Glucose Deprivation Injury (OGD) and Reoxygenation (OGD/R) in Chicken Hippocampal Cell Cultures.	Oxygen	96-102	growth hormone	Gallus gallus	0-14
34399419-2	2021	We investigate the role of the main air constituents nitrogen, oxygen and water on the efficiency of radiative recombination in GaN nanostructures as a function of different surface treatments and at temperatures up to 200 C. Oxygen and water exposures exhibit a complex behavior as they can both act quenching and enhancing on the photoluminescence intensity dependent on the temperature.	Oxygen	63-69	gigaxonin	Homo sapiens	128-131
34399419-2	2021	We investigate the role of the main air constituents nitrogen, oxygen and water on the efficiency of radiative recombination in GaN nanostructures as a function of different surface treatments and at temperatures up to 200 C. Oxygen and water exposures exhibit a complex behavior as they can both act quenching and enhancing on the photoluminescence intensity dependent on the temperature.	Oxygen	226-232	gigaxonin	Homo sapiens	128-131
16997902-1	2006	Ascorbate oxidase (AO) is a cell wall-localized enzyme that uses oxygen to catalyse the oxidation of ascorbate (AA) to the unstable radical monodehydroascorbate (MDHA) which rapidly disproportionates to yield dehydroascorbate (DHA) and AA, and thus contributes to the regulation of the AA redox state.	Oxygen	65-71	L-ascorbate oxidase-like	Nicotiana tabacum	19-21
34346754-4	2021	MBP1 deletion caused an obvious decrease in the final ethanol concentration under oxygen-limited (without agitation), but not under aerobic, conditions (130 rpm).	Oxygen	82-88	transcription factor MBP1	Saccharomyces cerevisiae S288C	0-4
16686439-7	2006	Thus, metabolic-sensing by AMPK underpins the cell-specific response of O2-sensing cells to hypoxia.	Oxygen	72-74	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-31
34346754-5	2021	Furthermore, the mbp1Delta strain showed 84% and 35% decreases in respiration intensity under aerobic and oxygen-limited conditions, respectively.	Oxygen	106-112	transcription factor MBP1	Saccharomyces cerevisiae S288C	17-21
34346754-6	2021	These findings indicate that MBP1 plays an important role in responding to variations in oxygen content and is involved in the regulation of respiration and fermentation.	Oxygen	89-95	transcription factor MBP1	Saccharomyces cerevisiae S288C	29-33
34455300-5	2021	When an oxygen was inserted into the linker of 4d, 4f demonstrated better water solubility, a more potent ability in degrading CYP1B1 and reversing drug resistance, and a promising selectivity.	Oxygen	8-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	127-133
16686426-9	2006	Rat PC12 cells share properties with O2-sensing glomus cells of the carotid body, including hypoxia-inducible expression of tyrosine hydroxylase, the rate limiting enzyme for catecholamine biosynthesis.	Oxygen	37-39	tyrosine hydroxylase	Rattus norvegicus	124-144
34464747-14	2021	DF-induced mitochondrial dysfunction which was demonstrated by decreased oxygen consumption rate, an increased ROS production and a reduced MnSOD level, were all reversed by metformin in an EPAC-dependent manner.	Oxygen	73-79	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	190-194
34464482-7	2021	Furthermore, inhibition of PDK2 synergistically enhanced cisplatin sensitivity by activating the electron transport chain and by increasing the production of mitochondrial reactive oxygen species.	Oxygen	181-187	pyruvate dehydrogenase kinase 2	Homo sapiens	27-31
34578599-4	2021	According to the TGA, the observed drop in catalytic activity is also associated with a large loss of oxygen from the perovskite structure.	Oxygen	102-108	T-box transcription factor 1	Homo sapiens	17-20
16686427-8	2006	Co-substrate and co-factor requirements for Fe(II), ascorbate, and the Krebs cycle intermediate 2-OG, and inducible changes in the cellular abundance of three closely related HIF prolyl hydroxylases (PHD1-3) provide additional interfaces with cellular oxygen status that may be important in regulating the oxygen-sensitive signal.	Oxygen	252-258	egl-9 family hypoxia inducible factor 2	Homo sapiens	200-206
16686427-8	2006	Co-substrate and co-factor requirements for Fe(II), ascorbate, and the Krebs cycle intermediate 2-OG, and inducible changes in the cellular abundance of three closely related HIF prolyl hydroxylases (PHD1-3) provide additional interfaces with cellular oxygen status that may be important in regulating the oxygen-sensitive signal.	Oxygen	306-312	egl-9 family hypoxia inducible factor 2	Homo sapiens	200-206
34379483-6	2021	Understanding that fat is "burned" with inhaled oxygen and most of the mass lost must be exhaled as carbon dioxide might help individuals create realistic weight loss expectations.	Oxygen	48-54	FAT atypical cadherin 1	Homo sapiens	19-22
16137652-0	2005	Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction.	Oxygen	22-24	heme oxygenase 2	Homo sapiens	0-15
34469714-0	2021	Competing endogenous RNA network associated with oxygen-induced retinopathy: expression of the network and identification of the MALAT1/miR-124-3p/EGR1 regulatory axis.	Oxygen	49-55	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	129-135
34469714-0	2021	Competing endogenous RNA network associated with oxygen-induced retinopathy: expression of the network and identification of the MALAT1/miR-124-3p/EGR1 regulatory axis.	Oxygen	49-55	microRNA 124a-3	Mus musculus	136-146
34420370-4	2021	Angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production were reduced by disruption of the cPLA2alpha or Cyp1b1 genes or by administration of the arachidonic acid metabolism inhibitor 5,8,11,14-eicosatetraynoic acid to cPLA2alpha+/+/Cyp1b1+/+ mice.	Oxygen	112-118	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	172-182
34420370-4	2021	Angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production were reduced by disruption of the cPLA2alpha or Cyp1b1 genes or by administration of the arachidonic acid metabolism inhibitor 5,8,11,14-eicosatetraynoic acid to cPLA2alpha+/+/Cyp1b1+/+ mice.	Oxygen	112-118	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	300-310
34237372-6	2021	The oxygen permeability of CS film decreased by up to 84% at 7 wt% BNNP loading.	Oxygen	4-10	citrate synthase	Homo sapiens	27-29
34164831-3	2021	The activation of HMGB1 secretion involves viral induction of reactive oxygen species and is mediated by the p38/STAT1 axis.	Oxygen	71-77	high mobility group box 1	Homo sapiens	18-23
16287861-6	2005	Growth in physiological (3%) oxygen or in the presence of an antioxidant prevented the development of the DNA damage foci in WRN-depleted cells, whereas acute oxidative stress led to inefficient repair of the lesions.	Oxygen	29-35	WRN RecQ like helicase	Homo sapiens	125-128
34628937-2	2021	Ang II (700 ng/kg per minute, SC) increased mean arterial blood pressure (BP), systolic and diastolic BP measured by radiotelemetry, renal fibrosis, and reactive oxygen species production in wild-type mice (cPLA2alpha+/+/Cyp1b1+/+) that were enhanced by ovariectomy and abolished in intact and ovariectomized-cPLA2alpha-/-/Cyp1b1+/+ mice.	Oxygen	162-168	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	207-217
34656824-1	2021	NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2 -.	Oxygen	119-123	NADPH oxidase 4	Mus musculus	0-15
34331963-6	2021	FUNDC1 ablation unmasked HFD-evoked rises in fatty acid synthase ACSL4, necroptosis, inflammation, ferroptosis, mitochondrial O2- production, and mitochondrial injury as well as dampened autophagy and DNA repair enzyme 8-oxoG DNA glycosylase 1 (OGG1) but not apoptosis, the effect of which except ACSL4 and its regulator SP1 was reversed by LIP-1.	Oxygen	126-129	FUN14 domain containing 1	Homo sapiens	0-6
34656824-1	2021	NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2 -.	Oxygen	119-123	NADPH oxidase 4	Mus musculus	17-21
16174769-2	2005	In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have activities comparable to those of their human counterparts.	Oxygen	91-97	alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase	Mus musculus	116-121
34656824-2	2021	The ratio of NOX4-derived H2O2 and O2 - can be altered by coenzyme Q (CoQ) mimics.	Oxygen	35-37	NADPH oxidase 4	Mus musculus	13-17
34390895-6	2021	We hypothesize that the intermittent use of the oxygen ionizer generating negative oxygen ion clusters (O2-(H2O)n) and sodium bicarbonate nebulizer (generating HCO3-); when connected to ventilator inlet or oxygen concentrator will neutralize the spike protein of the virus in respiratory tract and lungs and change the lung environment to neutral/alkaline condition respectively facilitating improved oxygen pressure in blood.	Oxygen	48-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	246-251
34481229-5	2021	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.	Oxygen	480-486	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	209-257
16284587-7	2005	RESULTS: In a hypoxic environment (2% O2), rat nucleus pulposus cells showed a persistent phosphorylation of p38 and ERK proteins; pERK catalyzed the phosphorylation of Elk1-Gst fusion protein.	Oxygen	38-40	mitogen activated protein kinase 14	Rattus norvegicus	109-112
34481229-5	2021	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.	Oxygen	480-486	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	259-263
34246992-5	2021	This is due to the formation of Cl2 - in seawater which could react with HO2  and prevent the formation of O2 -, thus inhibit the photo aging process of PP MPs under light irradiation.	Oxygen	107-111	heme oxygenase 2	Homo sapiens	73-76
16284587-7	2005	RESULTS: In a hypoxic environment (2% O2), rat nucleus pulposus cells showed a persistent phosphorylation of p38 and ERK proteins; pERK catalyzed the phosphorylation of Elk1-Gst fusion protein.	Oxygen	38-40	ETS transcription factor ELK1	Rattus norvegicus	169-173
34502940-5	2021	It is shown that EP/14IFR/2Ba composite has the highest limiting oxygen index (LOI) value of 30.7%.	Oxygen	65-71	prostaglandin E receptor 2	Homo sapiens	17-27
34737635-9	2021	HK-II siRNA increased the oxygen consumption rate of cells, significantly inhibited lactic acid production and glucose consumption, and significantly suppressed the upregulation of HK-II, pyruvate kinase M2 (PKM2), pyruvate dehydrogenase (PDH), phosphofructokinase platelet (PFKP), lactate dehydrogenase (LD), and citrate synthase (CS) (all, P<0.01).	Oxygen	26-32	hexokinase 2	Homo sapiens	0-5
16358018-0	2005	Mechanism of HCS + O2 reaction: hydrogen- or oxygen-transfer?	Oxygen	19-21	holocarboxylase synthetase	Homo sapiens	13-16
16552951-11	2005	When cultured in 1% or 21% oxygen pressure for 3 days, CD31+ EPCs were inhibited more efficiently by siRNA-HIF-1alpha than by pEGFP (P &lt; 0.05).	Oxygen	27-33	platelet and endothelial cell adhesion molecule 1	Homo sapiens	55-59
34769027-2	2021	Cells respond to oxygen deprivation by activating cytoprotective programs, such as mitochondrial connexin43 (mCx43) overexpression and the opening of mitochondrial KATP channels, aimed to reduce mitochondrial dysfunction.	Oxygen	17-23	gap junction protein, alpha 3	Mus musculus	109-114
34416105-5	2021	Regarding the mitochondria, MI and Nox4KO decreased the protein abundance of citrate synthase and subunits of electron transport system (ETS) complexes and increased mitochondrial O2 flux (JO2) and H2O2 emission (JH2O2) normalized to citrate synthase.	Oxygen	180-182	NADPH oxidase 4	Mus musculus	35-39
16061377-1	2005	A new mechanism is proposed to explain how coproporphyrinogen oxidase performs two oxidative decarboxylations on a porphyrinogen substrate without the aid of cofactors or metal ions in the presence of molecular oxygen.	Oxygen	211-217	coproporphyrinogen oxidase	Homo sapiens	43-69
34439552-4	2021	We show that cytokines increase O2 - production after 2 h in WT and NOX1 KO but not in NOX2 KO islets.	Oxygen	32-36	NADPH oxidase 1	Mus musculus	68-72
34925811-7	2021	In ISO-induced myocardial infarction, the J-point, heart rate, creatine kinase, lactate dehydrogenase, superoxide dismutase, catalase, malondialdehyde, glutathion, and reactive oxygen species decreased in mice after 18beta-GA treatment.	Oxygen	177-183	olfactory receptor family 2 subfamily F member 1B	Mus musculus	216-222
16040738-1	2005	The nonsymbiotic tomato hemoglobin SOLly GLB1 (Solanum lycopersicon) is shown to form a homodimer of approximately 36 kDa with a high affinity for oxygen.	Oxygen	147-153	non-symbiotic hemoglobin class 1	Solanum lycopersicum	41-45
34618435-5	2021	Radical-terminating hydroperoxide formation from the peroxy radical (RO2) reaction with HO2 and organonitrate formation from RO2 + NO are not observed in the gas phase, possibly due to low volatility; constraints for their branching ratios are instead derived by mass balance.	Oxygen	53-67	heme oxygenase 2	Homo sapiens	88-91
34321238-8	2021	In conclusion, DRD2 may promote the progression of malignant tumors induced by psychological stress via activation of the oxygen-independent HIF-1alpha pathway, and TFP may serve as a therapeutic strategy for stress management in cancer patients.	Oxygen	122-128	dopamine receptor D2	Homo sapiens	15-19
34407506-6	2022	All eta2 values were lower for long-distance corridor walk V O2 (eta2 <= 11%).	Oxygen	61-63	DNA polymerase iota	Homo sapiens	4-8
34407506-6	2022	All eta2 values were lower for long-distance corridor walk V O2 (eta2 <= 11%).	Oxygen	61-63	DNA polymerase iota	Homo sapiens	65-69
34381129-10	2021	We found that HDAC1 inhibition promoted the infarct volume, neuronal loss, DNA damage, neuronal apoptosis after stroke, and levels of reactive oxygen species and inflammation cytokines.	Oxygen	143-149	histone deacetylase 1	Rattus norvegicus	14-19
34293261-4	2021	This heterogeneous system has been shown to be a powerful and robust molecular hybrid anode for electrocatalytic water oxidation into molecular oxygen, achieving current densities in the range of 200 mA/cm2 at pH 7 under an applied potential of 1.45 V vs NHE.	Oxygen	144-150	solute carrier family 9 member C1	Homo sapiens	255-258
34679958-10	2021	This study demonstrated that the soil microbial community and availability of oxygen significantly affected the changes in moisture content, pH, and bacterial composition during the decomposition process.	Oxygen	78-84	phenylalanine hydroxylase	Homo sapiens	141-143
16140323-6	2005	The cardiac protection initiated by antimycin A is dependent on the activation of p38-MAPK which occurs, at least in part, in response to oxygen-derived free radicals.	Oxygen	138-144	mitogen-activated protein kinase 14	Mus musculus	82-85
34746697-5	2021	Furthermore, MYB70 modulates root system development (RSA) which is associated with increased conjugated IAA content and H2O2/O2  - ratio but reduced root suberin deposition, consequently affecting nutrient uptake.	Oxygen	126-131	myb domain protein 70	Arabidopsis thaliana	13-18
34348800-5	2021	Also, the mitochondrial efficiency expressed as the complex 1 and complex 1 + 2 respiratory control ratio (RCR) values for cardiac mitochondrial O2 consumption in B:ICR was significantly lower than that in Korl:ICR with higher level of state 2 respiration by glutamate/malate and UCP3 expression in cardiac muscle.	Oxygen	145-147	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	280-284
34361042-0	2021	Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain.	Oxygen	107-113	swiss cheese	Drosophila melanogaster	8-20
34372125-6	2021	Barrier properties were improved by combining the biopolymers, and water vapor transmission rate (WVTR) was reduced by 15-45% and oxygen permeability (OTR) up to 45% by adding nanocellulose compared to single biopolymer formulations.	Oxygen	130-136	oxytocin receptor	Homo sapiens	151-154
34547729-5	2021	Temperature-dependent neutron diffraction results show a rapid decay in structural parameters (lattice-striction and transition metal-oxygen bond length) around TN.	Oxygen	134-140	C-type lectin domain family 3 member B	Homo sapiens	161-163
16218730-1	2005	Programmable control over the overall structure of SnO(2) nanowires grown by vapor-solid synthesis is shown to be possible by pulse modulating the flow rate of the carrier gas in which oxygen (one of the reactants) is entrained.	Oxygen	185-191	strawberry notch homolog 1	Homo sapiens	51-54
34218417-4	2021	SETD3 promotes neuronal survival after both glucose and oxygen deprivation/reoxygenation (OGD/R) and cerebral I/R injury, and knockdown of SETD3 increases OGD/R-induced neuronal death.	Oxygen	56-62	SET domain containing 3, actin histidine methyltransferase	Rattus norvegicus	0-5
34255515-6	2021	In hypoxia (<0.1% O2), the inhibition of the CREBBP/EP300 bromodomain results in the enhanced stabilization of HIF-1alpha.	Oxygen	18-20	E1A binding protein p300	Homo sapiens	52-57
34376376-3	2021	We reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor (HIF), their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor, respectively, as well as their non-canonical functions revealed recently.	Oxygen	124-130	von Hippel-Lindau tumor suppressor	Homo sapiens	41-44
34376376-3	2021	We reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor (HIF), their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor, respectively, as well as their non-canonical functions revealed recently.	Oxygen	124-130	von Hippel-Lindau tumor suppressor	Homo sapiens	45-49
15936777-8	2005	These reactive oxygen molecules and increased intracellular free calcium may mediate the increase in Jun-AP1 expression and JNK activation induced by G treatment in MC.	Oxygen	15-21	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-108
34513548-1	2021	Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane.	Oxygen	100-102	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
34513548-1	2021	Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane.	Oxygen	100-102	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
34573126-9	2021	By contrast, PEX7 mutation caused changes in Cd-induced hydrogen peroxide (H2O2) and superoxide anion (O2 -) levels in the roots, delaying ROS-scavenging.	Oxygen	103-107	peroxin 7	Arabidopsis thaliana	13-17
16688932-11	2005	In conclusion, this study demonstrates an age-related decline in Cu/Zn-SOD and IDO activities, the two enzymes responsible for scavenging O2*-.	Oxygen	138-140	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	79-82
34536415-8	2022	RESULTS: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1beta, IL-6, IL-8 and TNFalpha and production of reactive oxygen species.	Oxygen	285-291	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
34250856-5	2021	Beyond cytotoxicity, the most dangerous reported risk associated with hydrogen peroxide in hip arthroplasties was an oxygen embolism in an unvented femoral canal and acrylic bone cement, consequentially leading to cardiac arrest.	Oxygen	117-123	hedgehog interacting protein	Homo sapiens	91-94
16039193-1	2005	BACKGROUND: Nesiritide is a recombinant brain-type natriuretic peptide (BNP), which decreases pulmonary arterial (PA) pressures and myocardial oxygen consumption while increasing coronary flow and urine output.	Oxygen	143-149	natriuretic peptide B	Homo sapiens	40-70
34161725-6	2021	A planar intramolecular charge transfer (PICT) and highly fluorescent excited state are populated for the oxygen-functionalized molecules NPI-PTZ2,3 and NPI-PTZ5; on the other hand, a twisted intramolecular charge transfer (TICT) state is produced upon photoexcitation of the oxygen-free derivatives NPI-PTZ1 and NPI-PTZ4, with the fluorescence being thus significantly quenched.	Oxygen	276-282	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	300-308
34154323-4	2021	Working on yeast Dph1-Dph2, we found that consistent with the known oxygen sensitivity, the (4Fe-4S) cluster is easily degraded into a (3Fe-4S) cluster.	Oxygen	68-74	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	17-21
34257816-0	2021	Development and Validation of a Multivariable Predictive Model for Mortality of COVID-19 Patients Demanding High Oxygen Flow at Admission to ICU: AIDA Score.	Oxygen	113-119	axin interactor, dorsalization associated	Homo sapiens	146-150
34540768-3	2021	The aim of the study is to report the trend of incidence of ROP among EP infants in a large neonatal intensive care unit in China over the past 10-year period, in relation with the overall survival rate and the change of oxygen saturation targets.	Oxygen	221-227	epiregulin	Homo sapiens	70-72
34340139-13	2021	Although this growth advantage disappeared at 7 days posthatch, a low oxygen concentration during incubation resulted in a higher FCR at 7 days posthatch.	Oxygen	70-76	FCR	Gallus gallus	130-133
34340139-15	2021	Oxygen concentrations during incubation affected body development during incubation and FCR in the first 7 days posthatch.	Oxygen	0-6	FCR	Gallus gallus	88-91
34343857-3	2021	We demonstrate here that the regenerative vasculature can be specified as arterial and venous capillary vessels based upon endothelial surface markers of CD31 and Endomucin (EMCN), with CD31+EMCN- vessels exhibiting higher flowrate and higher oxygen tension (pO2) than CD31+EMCN+ vessels.	Oxygen	243-249	platelet and endothelial cell adhesion molecule 1	Homo sapiens	186-190
16039193-1	2005	BACKGROUND: Nesiritide is a recombinant brain-type natriuretic peptide (BNP), which decreases pulmonary arterial (PA) pressures and myocardial oxygen consumption while increasing coronary flow and urine output.	Oxygen	143-149	natriuretic peptide B	Homo sapiens	72-75
34257823-8	2021	Interestingly, suppressing the function of Epac1 through VT or ESI-09 (an Epac inhibitor) treatment during I/R reduced the myocardial infarct size, cardiomyocyte apoptosis, and reactive oxygen species production; alleviated mitochondrial dysfunction by increasing mitochondrial membrane potential; elevated MFN2 expression; and inhibited Drp1 expression.	Oxygen	186-192	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	43-48
34257823-8	2021	Interestingly, suppressing the function of Epac1 through VT or ESI-09 (an Epac inhibitor) treatment during I/R reduced the myocardial infarct size, cardiomyocyte apoptosis, and reactive oxygen species production; alleviated mitochondrial dysfunction by increasing mitochondrial membrane potential; elevated MFN2 expression; and inhibited Drp1 expression.	Oxygen	186-192	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	74-78
34352266-0	2021	TLR2 signaling contributes to the angiogenesis of oxygen-induced retinopathy.	Oxygen	50-56	toll-like receptor 2	Mus musculus	0-4
16036361-6	2005	We here demonstrate that IRP1 activity and expression of TfR are solely dependent on H2O2 when co-released O2*- with from xanthine oxidase.	Oxygen	87-89	aconitase 1	Homo sapiens	25-29
34352266-1	2021	PURPOSE: To evaluate the role of Toll-like receptor 2 (TLR2) signaling in retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	121-127	toll-like receptor 2	Mus musculus	33-53
34352266-1	2021	PURPOSE: To evaluate the role of Toll-like receptor 2 (TLR2) signaling in retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	121-127	toll-like receptor 2	Mus musculus	55-59
34160461-10	2021	mPAP correlated best with PA-Ao ratio, PA diameter, oxygen desaturation during six-minute walk test, and echocardiographic variables.	Oxygen	52-58	phospholipid phosphatase 1	Mus musculus	0-4
34328028-0	2021	In Situ Oxygen Generation Enhances the SCAP Survival in Hydrogel Constructs.	Oxygen	8-14	SREBF chaperone	Homo sapiens	39-43
16036361-6	2005	We here demonstrate that IRP1 activity and expression of TfR are solely dependent on H2O2 when co-released O2*- with from xanthine oxidase.	Oxygen	87-89	transferrin receptor	Homo sapiens	57-60
34158477-5	2021	Likewise, Alb activation of hHv1 in neutrophils is required to sustain production and release of reactive oxygen species during the immune respiratory burst.	Oxygen	106-112	hydrogen voltage gated channel 1	Homo sapiens	28-32
16177675-1	2005	AIM: Aim of the study was to evaluate if brain natriuretic peptide (BNP) levels, a cardiac neurohormone well correlated with prognosis in chronic heart failure (CHF), are associated with enhanced ventilatory response to exercise, in ambulatory patients with intermediate peak oxygen uptake (PVO2).	Oxygen	276-282	natriuretic peptide B	Homo sapiens	41-66
34220513-16	2021	Compared to the oxygen-glucose deprivation/reperfusion group, the protein and mRNA expressions of p-JNK, Bax, cleaved Caspase3 was decreased significantly.	Oxygen	16-22	caspase 3	Rattus norvegicus	118-126
33691863-0	2021	Effects of Microwave and Furnace Annealing for P-Type SnO Thin Film Material in Oxygen Ambient.	Oxygen	80-86	strawberry notch homolog 1	Homo sapiens	54-57
16177675-1	2005	AIM: Aim of the study was to evaluate if brain natriuretic peptide (BNP) levels, a cardiac neurohormone well correlated with prognosis in chronic heart failure (CHF), are associated with enhanced ventilatory response to exercise, in ambulatory patients with intermediate peak oxygen uptake (PVO2).	Oxygen	276-282	natriuretic peptide B	Homo sapiens	68-71
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	carbonic anhydrase 9	Homo sapiens	164-168
34816916-8	2021	The correlation analysis showed that, in acute aortic dissection patients, the high-mobility group box 1 and receptor for advanced glycation end products levels were negatively correlated with partial pressure of oxygen/fraction of inspired oxygen, respectively (p<0.05).	Oxygen	213-219	high mobility group box 1	Homo sapiens	79-117
15890661-6	2005	We also found that exposure of mice to 90% O2 for 4 days, sufficient to lead to consumption of glutathione, oxidation of protein thiols, and accumulation of airspace protein-associated carbonyl moieties, blocked the permeabilizing activity of lavage fluid from SP-A+/+ mice.	Oxygen	43-45	surfactant associated protein A1	Mus musculus	261-265
34816916-8	2021	The correlation analysis showed that, in acute aortic dissection patients, the high-mobility group box 1 and receptor for advanced glycation end products levels were negatively correlated with partial pressure of oxygen/fraction of inspired oxygen, respectively (p<0.05).	Oxygen	241-247	high mobility group box 1	Homo sapiens	79-117
34846397-7	2021	These advantageous features are key to the rapid oxygen reduction kinetics observed under polymer electrolyte membrane (PEM) fuel cell MEA testing conditions.	Oxygen	49-55	mucin 1, cell surface associated	Homo sapiens	120-123
34204517-7	2021	GLUT1 and GLUT3 were upregulated by low oxygen.	Oxygen	40-46	solute carrier family 2 member 1	Bos taurus	0-5
34513016-2	2021	The complex exhibits one core in which three CuII metal centres are mutually inter-connected, two by two, via three phenolato oxygen anions acting in a mu2-mode.	Oxygen	126-132	adaptor related protein complex 1 subunit mu 2	Homo sapiens	152-155
34140895-0	2021	MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats.	Oxygen	80-86	mitogen activated protein kinase kinase 1	Rattus norvegicus	0-6
15978586-2	2005	Using the yeast two-hybrid screening system, we found that the oxygen dependent degradation (ODD) domain of HIF-1alpha interacts with necdin, a growth suppressor.	Oxygen	63-69	necdin, MAGE family member	Homo sapiens	134-140
34184431-10	2021	CONCLUSIONS: These findings indicate that microvascular kidney oxygen tension is maintained in the superficial cortex but reduced in deeper cortical and outer medullary tissue, possibly due to the regional impact of SGLT-2 inhibition on tissue metabolism.	Oxygen	63-69	solute carrier family 5 member 2	Rattus norvegicus	216-222
34135757-3	2021	In the model of mouse with genetic deficiency in a H2S natural synthesis enzyme cystathionine-gamma-lyase (CSE), we found that arterial oxygen saturation (SaO2) was decreased compared with wild type mice.	Oxygen	136-142	cystathionase (cystathionine gamma-lyase)	Mus musculus	80-105
34135757-3	2021	In the model of mouse with genetic deficiency in a H2S natural synthesis enzyme cystathionine-gamma-lyase (CSE), we found that arterial oxygen saturation (SaO2) was decreased compared with wild type mice.	Oxygen	136-142	cystathionase (cystathionine gamma-lyase)	Mus musculus	107-110
34453220-0	2022	Knockdown of lncRNA SNHG15 Ameliorates Oxygen and Glucose Deprivation (OGD)-Induced Neuronal Injury via Regulating the miR-9-5p/TIPARP Axis.	Oxygen	39-45	small nucleolar RNA host gene 15	Mus musculus	20-26
34453220-11	2022	Our data showed that oxygen and glucose deprivation (OGD) could induce N-2a cell injury and enhance SNHG15 expression.	Oxygen	21-27	small nucleolar RNA host gene 15	Mus musculus	100-106
34400195-5	2022	TREX1-deficient fibroblasts and keratinocytes generated increased levels of reactive oxygen species in response to UV irradiation as well as increased levels of 8-oxo-guanine lesions after oxidative stress.	Oxygen	85-91	three prime repair exonuclease 1	Homo sapiens	0-5
34438746-8	2021	These metabolites may inhibit oxygen respiration by increasing the adipocytes cells and density, cause mitochondrial and endoplasmic reticulum dysfunction, produce inflammation, and finally lead to insulin resistance, thus increasing the risk of Type 2 diabetes, atherosclerosis, and other metabolic syndromes.	Oxygen	30-36	insulin	Oryctolagus cuniculus	198-205
15899860-2	2005	pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopoiesis, and oxygen (O(2)) delivery, for ubiquitin-mediated degradation in an O(2)-dependent manner.	Oxygen	178-184	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
34197627-3	2021	cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1-dependent proton leak, increased creatine-driven substrate cycle coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC-1 inhibitor, BMS-466442.	Oxygen	130-136	solute carrier family 7 member 10	Homo sapiens	400-405
34073998-2	2021	For such applications, recent attention has focused on utilizing the oxygen-insensitive glucose dehydrogenase (GDH) enzyme in place of the glucose oxidase (GOx) enzyme, which is sensitive to oxygen levels.	Oxygen	69-75	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	111-114
34073998-2	2021	For such applications, recent attention has focused on utilizing the oxygen-insensitive glucose dehydrogenase (GDH) enzyme in place of the glucose oxidase (GOx) enzyme, which is sensitive to oxygen levels.	Oxygen	191-197	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	88-109
34073998-2	2021	For such applications, recent attention has focused on utilizing the oxygen-insensitive glucose dehydrogenase (GDH) enzyme in place of the glucose oxidase (GOx) enzyme, which is sensitive to oxygen levels.	Oxygen	191-197	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	111-114
34138317-2	2021	Herein, we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the "precise strike" of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid (HA) and hypoxia-dependent factor carbonic anhydrase IX (CA IX)-inhibitor acetazolamide (AZ).	Oxygen	38-44	carbonic anhydrase 9	Homo sapiens	241-262
34138317-2	2021	Herein, we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the "precise strike" of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid (HA) and hypoxia-dependent factor carbonic anhydrase IX (CA IX)-inhibitor acetazolamide (AZ).	Oxygen	38-44	carbonic anhydrase 9	Homo sapiens	264-269
34272733-3	2021	Our results showed that 0.05% CAT immersion for 5 min alleviated browning during cold storage (4 C, 8 days), which was accompanied by a higher lightness and lower redness; additionally, lower H2 O2 and O2  - contents were found.	Oxygen	202-204	LOC102577773	Solanum tuberosum	30-33
15899860-2	2005	pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopoiesis, and oxygen (O(2)) delivery, for ubiquitin-mediated degradation in an O(2)-dependent manner.	Oxygen	186-191	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
15899860-2	2005	pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopoiesis, and oxygen (O(2)) delivery, for ubiquitin-mediated degradation in an O(2)-dependent manner.	Oxygen	186-190	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
34197017-3	2021	In view of these factors, Ti4+ -substituted Li2 IrO3 (Li2 Ir0.75 Ti0.25 O3 ) is synthesized, which undergoes an oxygen redox reaction with suppressed voltage decay, yielding improved electrochemical performance and good capacity retention.	Oxygen	112-118	ATP binding cassette subfamily A member 12	Homo sapiens	44-47
15750626-6	2005	Investigation of both N-terminal and C-terminal (aa 727-826) oxygen-regulated proline and asparagine hydroxylation of HIF-1alpha revealed that both are inhibited during high cell density, as determined by impaired capture of HIF-1alpha by VHL and enhanced C-terminal transactivation.	Oxygen	61-67	von Hippel-Lindau tumor suppressor	Homo sapiens	239-242
34197017-3	2021	In view of these factors, Ti4+ -substituted Li2 IrO3 (Li2 Ir0.75 Ti0.25 O3 ) is synthesized, which undergoes an oxygen redox reaction with suppressed voltage decay, yielding improved electrochemical performance and good capacity retention.	Oxygen	112-118	ATP binding cassette subfamily A member 12	Homo sapiens	54-57
34197017-4	2021	It is shown that the increased bond covalency upon Ti4+ substitution results in structural stability, tuning the phase stability from O3 to O1" upon de-lithiation during charging compared with O3 to T3 and O1 for pristine Li2 IrO3 , thereby facilitating the oxidation of oxygen.	Oxygen	271-277	ATP binding cassette subfamily A member 12	Homo sapiens	222-225
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Oxygen	19-25	citrate synthase	Homo sapiens	69-71
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Oxygen	19-25	citrate synthase	Homo sapiens	186-188
34179925-10	2021	RESULTS: After the intervention, the E and EP groups had greater maximal work rate, peak oxygen consumption, and muscle power during muscle contractions at 180 /sec than that in the C group (P<0.05).	Oxygen	89-95	epiregulin	Homo sapiens	43-45
34083037-2	2021	It is assumed that damage of the genetic material via inflammation and reactive oxygen species by CS lead to formation of malignant cells.	Oxygen	80-86	citrate synthase	Homo sapiens	98-100
34320035-7	2021	Cultured Tfam-deficient NSCs showed a reduction in reactive oxygen species produced by the mitochondria.	Oxygen	60-66	transcription factor A, mitochondrial	Mus musculus	9-13
34356378-4	2021	Moreover, GLP-1 exhibited stronger antioxidant activities than GLP-2 in five different assays: 2,2"-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), hydroxyl radical, superoxide anion radical, ferric reducing antioxidant power (FRAP), and oxygen radical antioxidant capacity (ORAC).	Oxygen	247-253	glucagon	Mus musculus	10-15
34259984-10	2022	Inhibition of xCT exacerbated cardiomyocyte hypertrophy and boosted the levels of ferroptosis biomarkers Ptgs2, malondialdehyde, and reactive oxygen species induced by Ang II, while overexpression of xCT opposed these detrimental effects.	Oxygen	142-148	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	14-17
16852147-8	2005	A gold-mercury amalgam tip was used to quantitatively reduce dissolved O2 (mediator) to HO2-, which was decomposed back to oxygen at the catalyst substrate.	Oxygen	71-73	heme oxygenase 2	Homo sapiens	88-91
34341659-5	2021	Large infiltrates by Arginase 1+ G-MDSC (Arg+G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen species) were found in the lungs of patients who died from COVID-19 complications.	Oxygen	119-125	NADPH oxidase 1	Homo sapiens	65-70
34196548-5	2021	It can be proposed that the luminescence property of oat-beta-Glu originates from the spatial conjugation of the oxygen atoms of oat-beta-Glu.	Oxygen	113-119	ornithine aminotransferase	Homo sapiens	53-56
35611145-0	2022	Oxygen efficient respiratory Aid (OxEraTM) device: A safety study.	Oxygen	0-6	activation induced cytidine deaminase	Homo sapiens	29-32
35611145-2	2022	The Oxygen Efficient Respiratory Aid (OxEraTM) device has been granted SAPHRA approval for emergency COVID-19 pandemic use.	Oxygen	4-10	activation induced cytidine deaminase	Homo sapiens	33-36
34196548-5	2021	It can be proposed that the luminescence property of oat-beta-Glu originates from the spatial conjugation of the oxygen atoms of oat-beta-Glu.	Oxygen	113-119	ornithine aminotransferase	Homo sapiens	129-132
16852147-8	2005	A gold-mercury amalgam tip was used to quantitatively reduce dissolved O2 (mediator) to HO2-, which was decomposed back to oxygen at the catalyst substrate.	Oxygen	123-129	heme oxygenase 2	Homo sapiens	88-91
35278444-9	2022	Knockdown of MAPK15 resulted in decreased reactive oxygen species level and cell apoptosis induced by DON, indicating the existence of miR-330-MAPK15 regulatory axis in regulating DON toxicity.	Oxygen	51-57	mitogen-activated protein kinase 15	Homo sapiens	13-19
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	Oxygen	117-123	interleukin 18	Mus musculus	25-30
34081190-5	2021	Controlling for known risk factors for ROP and then adjusting for gestational age, number of transfusions and fraction of inspired oxygen (FiO2), the odds of ROP were 1.22 times greater (95% confidence interval, CI 1.01-1.48) with every additional week of noninvasive ventilation (p = 0.03).	Oxygen	131-137	opsin 1, long wave sensitive	Homo sapiens	158-161
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	Oxygen	117-123	interleukin 18	Mus musculus	174-179
35439835-7	2022	Both hemoglobin (p < 0.001) and muscle oxygen saturation measurements (p < 0.05) were higher in Humon Hex than for Moxy, and there was a reasonable reproducibility (ICC=0.35 for hemoglobin and 0.26 for muscle oxygen saturation).	Oxygen	39-45	hematopoietically expressed homeobox	Homo sapiens	102-105
35439835-7	2022	Both hemoglobin (p < 0.001) and muscle oxygen saturation measurements (p < 0.05) were higher in Humon Hex than for Moxy, and there was a reasonable reproducibility (ICC=0.35 for hemoglobin and 0.26 for muscle oxygen saturation).	Oxygen	209-215	hematopoietically expressed homeobox	Homo sapiens	102-105
33835608-0	2021	New Ag3 PO4 comparison material for stable oxygen isotope analysis.	Oxygen	43-49	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	4-7
15847434-8	2005	In the main mononuclear species of L2 and L3, the two HPO moieties stabilize the M(II) in a square planar geometry due to the two oxygen atoms of each HPO.	Oxygen	130-136	immunoglobulin kappa variable 3-15	Homo sapiens	35-44
35603420-4	2022	In CD133(+) cells, greater 18F-FDG uptake was accompanied by increased oxygen consumption rate (OCR) and reduced mitochondrial membrane potential and mitochondrial ROS, indicating increased proton leakage.	Oxygen	71-77	prominin 1	Homo sapiens	3-8
34276814-12	2021	Overexpression of NDUFA4L2 enhanced Warburg effects, enhanced aerobic glycolysis, reduced oxygen consumption, and lowered ROS production.	Oxygen	90-96	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	18-26
15877382-1	2005	The radicalization of unbleached lignocellulosic fibers obtained from thermomechanical (TMP) and chemothermomechanical (CTMP) pulps was performed in heterogeneous phase by reaction with dioxygen in the presence of N,N"-ethylenebis(salicylideneiminato)cobalt(II), [Co(salen)], as catalyst.	Oxygen	186-194	thioesterase superfamily member 4	Homo sapiens	120-124
35502893-8	2022	The resulting binuclear complex undergoes intramolecular electron transfer to give Fe(II), which later generates HO  from H2O2, plus MnO2+, which later decomposes to HO2 /O2 - (an Fe(III) reductant) and Mn(II), completing the catalytic cycle.	Oxygen	171-175	heme oxygenase 2	Homo sapiens	166-169
34202015-2	2021	Herein, the ratiometric fluorescent oxygen-sensing membrane was fabricated with the ratio of two emission wavelengths of platinum meso-tetra (pentafluorophenyl) porphyrin (PtP) doped in polystyrene particles and coumarin 6 (C6) captured into silica particles.	Oxygen	36-42	protein tyrosine phosphatase receptor type U	Homo sapiens	172-175
15904470-2	2005	The VHL protein binds to the alpha subunit of (HIF-alpha) for its oxygen-dependent degradation.	Oxygen	66-72	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
34202015-3	2021	The operation mechanism of the sensing membranes was based on (i) the fluorescence quenching effect of the PtP dye by oxygen molecules, and (ii) the consumption of oxygen levels in the glucose or lactate oxidation reactions under the catalysis of GOD or LOX.	Oxygen	118-124	protein tyrosine phosphatase receptor type U	Homo sapiens	107-110
34202015-3	2021	The operation mechanism of the sensing membranes was based on (i) the fluorescence quenching effect of the PtP dye by oxygen molecules, and (ii) the consumption of oxygen levels in the glucose or lactate oxidation reactions under the catalysis of GOD or LOX.	Oxygen	164-170	protein tyrosine phosphatase receptor type U	Homo sapiens	107-110
34222665-8	2021	This anti-obesity effect was mediated by the increased O2 consumption, CO2 production, and energy expenditure, which was further evidenced by the upregulation of uncoupling protein-1 (UCP-1) and metabolism-associated genes.	Oxygen	55-57	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	162-182
35183665-4	2022	We found that, however, the daytime concentrations of secondary aerosols during the lockdown period and normal period were rather similar when the corresponding odd oxygen (Ox O3+NO2, an indicator of photochemical processing avoiding the titration effect of O3 by freshly emitted NO) were at similar levels.	Oxygen	165-171	hypocretin neuropeptide precursor	Homo sapiens	173-175
35536460-0	2022	Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner.	Oxygen	76-82	microRNA 134	Homo sapiens	139-146
35411903-2	2022	In this work, PAN-based blend precursors are investigated using ReaxFF reactive molecular dynamics simulations with respect to the formation of all-carbon rings, the evolutions of oxygen-containing and nitrogen-containing species, and the migration of carbon atoms to form turbostratic graphene.	Oxygen	180-186	adenosine deaminase 2	Homo sapiens	14-17
34222665-8	2021	This anti-obesity effect was mediated by the increased O2 consumption, CO2 production, and energy expenditure, which was further evidenced by the upregulation of uncoupling protein-1 (UCP-1) and metabolism-associated genes.	Oxygen	55-57	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	184-189
34075953-5	2021	Herein, we designed a nanoprobe based on gold nanoparticles (Au NPs) to monitor the effect of different oxygen and nutrient conditions on the migration and invasion of breast cancer cells through detecting the changes in levels of RAB-22a and MMP-2 mRNA in living cells.	Oxygen	104-110	matrix metallopeptidase 2	Homo sapiens	243-248
15853801-7	2005	In addition, an in vitro reconstitution experiment using recombinant PsbOs and urea-washed PSII particles showed that oxygen evolution was better recoVERed by PsbO1 than by PsbO2.	Oxygen	118-124	PS II oxygen-evolving complex 1	Arabidopsis thaliana	159-164
34099668-3	2021	The highly reducible oxygen species provided by surface metal-oxide (M-O) interface could be activated by CO at low temperature (~50  C) with a high CO2 production rate of 487 mumolCO2 gPt-1 s-1 at 110  C. Experiment data combined with density functional calculation (DFT) results demonstrate that Pt cluster with surface Pt-O-Bi structure is the active site for CO oxidation via providing moderate CO adsorption and activating CO molecules with electron transformation between platinum atom and carbon monoxide.	Oxygen	21-27	glutamic--pyruvic transaminase	Homo sapiens	185-190
35043013-4	2022	The knockout of TRPV1 in UCP1 knockout mice further reduced functional brown adipose tissue (BAT) generation; decreased resting oxygen consumption, heat production, and locomotor activities; and was accompanied by severe mitochondrial respiratory dysfunction in BAT.	Oxygen	128-134	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	25-29
15885203-1	2005	Recent studies show that low oxygen tension levels in cell culture up-regulate the replication of human B19 parvovirus, Kaposi"s sarcoma, and human immunodeficiency viruses as well as the expression of viral oncogenic proteins.	Oxygen	29-35	eva-1 homolog C	Homo sapiens	104-107
35307349-7	2022	Finally, using oxygen-glucose deprivation (OGD) as an in vitro model for ischemia, we show that BDNF-TrkB signaling negatively impairs clustering of the main scaffolding protein at GABAergic postsynapse, gephyrin, whereby reducing GABAergic neurotransmission post-ischemia.	Oxygen	15-21	neurotrophic receptor tyrosine kinase 2	Homo sapiens	101-105
34149701-6	2021	Additionally, activated CD8+ T cells that migrate on ICAM-1 and CXCL12 consumed significantly more oxygen than stationary CD8+ T cells.	Oxygen	99-105	C-X-C motif chemokine ligand 12	Homo sapiens	64-70
15752707-7	2005	The present results indicate that the structures of the camphor analogs can sensitively influence the physical (spectroscopic) properties of the P450 dioxygen complex and could also affect its reactivity.	Oxygen	150-158	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	145-149
34130526-6	2021	Moreover, SHRs exhibited significantly increased central retinal thickness, inflammation, and reactive oxygen species production compared with WKY rats, and these effects were markedly attenuated by systemic administration of the UCHL1 inhibitor LDN57444.	Oxygen	103-109	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	230-235
35381273-2	2022	Herein, active photosynthetic Chlorophyceae (Chlorella, Chl) functionalized with black phosphorus nanosheets (BPNSs) through polyaspartic acid (PASP) and Fe3+ mediating "Lego building method" are utilized for photocatalyzed oxygen-evolving to realize photosynthesis enhanced synergistic photodynamic/chemodynamic/immune therapy.	Oxygen	224-230	chordin like 1	Homo sapiens	56-59
15790963-5	2005	We prevented retinal vessel development by raising newborn mice in a high-oxygen atmosphere, which leads, paradoxically, to retinal hypoxia (confirmed by using the oxygen-sensing reagent EF5).	Oxygen	74-80	angiogenin, ribonuclease A family, member 3	Mus musculus	187-190
35381273-4	2022	BPNSs loaded on the surface of Chl cells construct a type-II heterojunction with the chlorophyll in Chl cells, which improves the conversion efficiency of light through thoroughly separating photo-excited electrons and holes for 1O2 generation and O2 evolution, respectively.	Oxygen	248-250	chordin like 1	Homo sapiens	31-34
35381273-4	2022	BPNSs loaded on the surface of Chl cells construct a type-II heterojunction with the chlorophyll in Chl cells, which improves the conversion efficiency of light through thoroughly separating photo-excited electrons and holes for 1O2 generation and O2 evolution, respectively.	Oxygen	248-250	chordin like 1	Homo sapiens	100-103
34064586-0	2021	Oxygen Permeability of Silk Fibroin Hydrogels and Their Use as Materials for Contact Lenses: A Purposeful Analysis.	Oxygen	0-6	fibroin light chain	Bombyx mori	28-35
34602393-4	2021	The efficacy variables include: creatinine; cystatin C; TGF-beta levels; oxidants/reactive oxygen species production induced by TGF-beta; collagen levels (type 1 and 4); urinary albumin/creatinine ratio and Glomerular area.	Oxygen	91-97	transforming growth factor alpha	Homo sapiens	128-136
35348185-7	2022	Finally, the detection of reactive oxygen species, nitric oxide (NO) synthase and NO levels confirmed that CTRP9 inhibited the oxidative stress of HTR8/SVneo cells induced by HG through the reduction of ER stress.	Oxygen	35-41	C1q and TNF related 9	Homo sapiens	107-112
15790963-5	2005	We prevented retinal vessel development by raising newborn mice in a high-oxygen atmosphere, which leads, paradoxically, to retinal hypoxia (confirmed by using the oxygen-sensing reagent EF5).	Oxygen	164-170	angiogenin, ribonuclease A family, member 3	Mus musculus	187-190
15892408-3	2005	The aim of the study was to evaluate the effect of different ACP flow rates on cerebral oxygen saturation obtained by near infrared spectroscopy.	Oxygen	88-94	CPAT1	Homo sapiens	61-64
35571814-8	2022	The main reactions that inhibit temperature rise are R53 (H + CH3(+M) < = > CH4(+M)), R36 (H + O2 + H2O < = > HO2 + H2O), and R46 (H + HO2 < = > O2 + H2).	Oxygen	95-97	heme oxygenase 2	Homo sapiens	135-138
35571814-8	2022	The main reactions that inhibit temperature rise are R53 (H + CH3(+M) < = > CH4(+M)), R36 (H + O2 + H2O < = > HO2 + H2O), and R46 (H + HO2 < = > O2 + H2).	Oxygen	145-147	heme oxygenase 2	Homo sapiens	110-113
34141984-4	2021	Further, etfa+/ - mutant livers had reduced levels of FAD and glutathione and an increase in reactive oxygen species.	Oxygen	102-108	electron transfer flavoprotein subunit alpha	Homo sapiens	9-13
34141984-6	2021	Additionally, we found that adenosine triphosphate-linked mitochondrial oxygen consumption and mitochondrial membrane potential were reduced in etfa+/ - primary hepatocytes and that riboflavin supplementation corrected these defects.	Oxygen	72-78	electron transfer flavoprotein subunit alpha	Homo sapiens	144-148
15777842-3	2005	Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL.	Oxygen	66-72	von Hippel-Lindau tumor suppressor	Homo sapiens	199-203
34337330-8	2021	For an ex vivo organ cultured in high glucose medium (4.5 g/L or 25 mM) and normoxia, a larger bovine caudal disc (Cd1-2 to Cd3-4) had a central concentration of ~2.6 %O2, ~8 mM of glucose and a pH value of 6.7, while the smallest caudal discs investigated (Cd6-7 and Cd7-8), had a central concentration of ~6.5 %O2, ~12 mM of glucose and a pH value of 6.9.	Oxygen	168-170	CD2 molecule	Bos taurus	115-120
35384470-9	2022	Observed GPx peaks during post-feeding in gills are likely due to the exacerbated demands for ion fluxes and/or oxygen during feeding.	Oxygen	112-118	glutathione peroxidase 1	Oncorhynchus mykiss	9-12
35508278-11	2022	Real-time metabolic measurements of oxygen consumption rate and extracellular acidification rate revealed that SMTNL1 improved glycolysis and promoted the utilization of alternative carbon fuels.	Oxygen	36-42	smoothelin-like 1	Mus musculus	111-117
35485648-5	2022	Mechanistically, HKDC1 regulates HG-induced cell pyroptosis by modulating the production of reactive oxygen species and pyroptosis-induced cytokine release in EC.	Oxygen	101-107	hexokinase domain containing 1	Homo sapiens	17-22
35477503-4	2022	METHODS: In this study, we developed oncolytic herpes simplex virus type 1 expressing HMGB1 protein (HSV-HMGB1) and investigated the cytotoxic effect of HSV-HMGB1 and its parental virus (HSV-ble) on three colorectal cancer cells (HCT116, SW480, and HT29) under normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	275-281	high mobility group box 1	Homo sapiens	86-91
35477503-4	2022	METHODS: In this study, we developed oncolytic herpes simplex virus type 1 expressing HMGB1 protein (HSV-HMGB1) and investigated the cytotoxic effect of HSV-HMGB1 and its parental virus (HSV-ble) on three colorectal cancer cells (HCT116, SW480, and HT29) under normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	275-281	high mobility group box 1	Homo sapiens	105-110
15611098-7	2005	Evidence has also been obtained showing that in a NO- and O2-rich environment, PDI can form N2O3 in its hydrophobic domains.	Oxygen	58-60	prolyl 4-hydroxylase subunit beta	Homo sapiens	79-82
35572517-4	2022	Accumulation of misfolded proteins in the ER lumen, reactive oxygen species and exogenous stimulants like infections, chemical irritants and mechanical harm can induce ER stress, often followed by an ER stress response to reinstate cellular homeostasis.	Oxygen	61-67	epiregulin	Homo sapiens	168-170
35181435-7	2022	Furthermore, the degradation efficiency of Ag-Ag2S-CdS/CEPR was significantly reduced to ~5% in the presence of BQ ( O2- scavenger), indicating that  O2- is the major active species that can decompose MO dye under simulated solar light.	Oxygen	117-119	angiotensin II receptor type 1	Homo sapiens	46-50
35181435-7	2022	Furthermore, the degradation efficiency of Ag-Ag2S-CdS/CEPR was significantly reduced to ~5% in the presence of BQ ( O2- scavenger), indicating that  O2- is the major active species that can decompose MO dye under simulated solar light.	Oxygen	150-153	angiotensin II receptor type 1	Homo sapiens	46-50
35349262-0	2022	Incorporating Oxygen Atoms in a SnS2 Atomic Layer to Simultaneously Stabilize Atomic Hydrogen and Accelerate the Generation of Hydroxyl Radicals for Water Decontamination.	Oxygen	14-20	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
15669087-0	2005	Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responses.	Oxygen	10-16	arginine deiminase	Escherichia coli	41-45
35349262-4	2022	In this study, we noted that incorporating oxygen atoms could regulate the behavior of H* by creating a locally favorable electron-rich state of S atoms in the SnS2 catalyst.	Oxygen	43-49	sodium voltage-gated channel alpha subunit 11	Homo sapiens	160-164
35468689-0	2022	Safety and Efficacy of Systemic Anti-Scg3 Therapy to Treat Oxygen-Induced Retinopathy.	Oxygen	59-65	secretogranin III	Mus musculus	37-41
35601073-7	2022	A strong correlation between the ACE2 rs4343 G>A genotype distribution among COVID-19 patients was reported with respect to their comorbid conditions including sex (P<0.023), coronary artery disease (P<0.0001), oxygen saturation <60 mm Hg (P<0.0009) and antiviral therapy (0.003).	Oxygen	211-217	angiotensin converting enzyme 2	Homo sapiens	33-37
15738407-2	2005	We found that incubator oxygen levels influenced lymphocyte proliferation stimulated by two commonly used stimuli: Con A and antibodies that crosslink surface CD3 and CD28 to mimic antigen presentation.	Oxygen	24-30	CD28 molecule	Homo sapiens	167-171
35397644-3	2022	Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks" postmenstrual age to room-air or discharge with oxygen (<=0.5 L/min).	Oxygen	187-193	solute carrier family 38 member 4	Homo sapiens	83-87
35167880-0	2022	Hyperbaric oxygen therapy mitigates left ventricular remodeling, upregulates MMP-2 and VEGF, and inhibits the induction of MMP-9, TGF-beta1, and TNF-alpha in streptozotocin-induced diabetic rat heart.	Oxygen	11-17	matrix metallopeptidase 2	Rattus norvegicus	77-82
35457152-3	2022	Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species.	Oxygen	247-253	insulin receptor	Homo sapiens	109-125
15738407-6	2005	Thus, we conclude that the influence of oxygen levels on proliferation depends on the stimulus, and, most importantly from the standpoint of immune responses, culturing cells at atmospheric rather than physiologic oxygen levels results in significantly increased proliferation responses to the CD3/CD28 crosslinking, a proliferation stimulus commonly used to mimic T cell antigen receptor signaling.	Oxygen	40-46	CD28 molecule	Homo sapiens	298-302
35338668-4	2022	The O2 - -generating system in leukocytes is consisted of membrane cytochrome b 558 protein (a complex of p22-phox and gp91-phox proteins) and cytosolic p40-phox, p47-phox and p67-phox proteins.	Oxygen	4-6	neutrophil cytosolic factor 2	Homo sapiens	176-184
15713045-0	2005	Postmortem oxygen consumption by mitochondria and its effects on myoglobin form and stability.	Oxygen	11-17	myoglobin	Bos taurus	65-74
35535664-3	2022	It was found that a design concept with an oxygen-responsive dye in polymer nanoparticles and a pH-responsive dye in an organically modified siloxane polymer resulted in a robust pH/O2 dual optical sensor.	Oxygen	43-49	phenylalanine hydroxylase	Homo sapiens	179-181
35535664-3	2022	It was found that a design concept with an oxygen-responsive dye in polymer nanoparticles and a pH-responsive dye in an organically modified siloxane polymer resulted in a robust pH/O2 dual optical sensor.	Oxygen	182-184	phenylalanine hydroxylase	Homo sapiens	96-98
35535664-3	2022	It was found that a design concept with an oxygen-responsive dye in polymer nanoparticles and a pH-responsive dye in an organically modified siloxane polymer resulted in a robust pH/O2 dual optical sensor.	Oxygen	182-184	phenylalanine hydroxylase	Homo sapiens	179-181
35417709-0	2022	An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity.	Oxygen	3-9	occludin	Homo sapiens	50-58
35417709-3	2022	The interaction between SNHG12 and occludin is oxygen adaptive and could block Itch (an E3 ubiquitin ligase)-mediated ubiquitination and degradation of occludin in human BMECs.	Oxygen	47-53	occludin	Homo sapiens	35-43
35417709-6	2022	Together, we identify a direct TJ modulator lncRNA SNHG12 that is critical for the BBB integrity maintenance and oxygen adaption.	Oxygen	113-119	small nucleolar RNA host gene 12	Mus musculus	51-57
35455951-6	2022	Investigation of beta3-AR regulation over OIR progression revealed that the expression profile of beta3-AR depends on oxygen tension, similar to VEGF.	Oxygen	118-124	ferredoxin reductase	Mus musculus	23-25
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	neurotrophic receptor tyrosine kinase 1	Homo sapiens	274-279
35233843-9	2022	These modified molecules (e.g., Mito-honokiol, Mito-magnolol, Mito-metformin, Mito-atovaquone, Mito-hydroxyurea) accumulate in tumor cell mitochondria more effectively than in normal cells and inhibit mitochondrial respiration, induce reactive oxygen species, activate AMPK and redox transcription factors, and inhibit cancer cell proliferation.	Oxygen	244-250	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	269-273
35093630-0	2022	MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.	Oxygen	19-25	microRNA 107	Rattus norvegicus	0-7
35093630-0	2022	MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.	Oxygen	19-25	fibroblast growth factor 12	Rattus norvegicus	150-155
35610199-1	2022	Electrochemical oxygen reduction to hydrogen peroxide (H2O2) in acidic media, especially in proton exchange membrane (PEM) electrode assembly reactors, suffers from low selectivity and the lack of low-cost catalysts.	Oxygen	16-22	mucin 1, cell surface associated	Homo sapiens	118-121
35625933-7	2022	Moreover, UVC/SK2 caused higher oxidative stress in oral cancer cells than normal cells through the examination of reactive oxygen species, mitochondrial superoxide, and mitochondrial membrane potential.	Oxygen	124-130	sphingosine kinase 2	Homo sapiens	14-17
15663964-8	2005	While neuroglobin seems to be associated with oxygen consumption, a respiratory function of cytoglobin is unlikely.	Oxygen	46-52	neuroglobin	Mus musculus	6-17
35584239-5	2022	Further, we measured the temporal and spatial changes in oxygen and vessel perfusion in tumors in response to anti-VEGFR2 antibody (DC101) and an angiotensin-receptor blocker (losartan).	Oxygen	57-63	kinase insert domain protein receptor	Mus musculus	115-121
35332670-0	2022	Intelligent Nanodelivery System-Generated 1 O2 Mediates Tumor Vessel Normalization by Activating Endothelial TRPV4-eNOS Signaling.	Oxygen	44-46	transient receptor potential cation channel subfamily V member 4	Homo sapiens	109-114
15721254-3	2005	The half-life of the HIF-1alpha subunit is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	57-63	von Hippel-Lindau tumor suppressor	Homo sapiens	133-158
35433535-3	2022	By using lentivirus, we constructed microRNA34a (miR34a)-overexpressing or knockdown A549 cell lines, and exposure to hyperoxia to mimic oxygen induce lung injury.	Oxygen	137-143	microRNA 34a	Homo sapiens	36-47
35549905-8	2022	RESULTS: Twenty percent of serum collected from patients undergoing OLV downregulated the expression of Prdx6, leading to the activation of the NF-kappaB signaling pathway, which was associated with the subsequent overproduction of inflammatory cytokines and reactive oxygen species.	Oxygen	268-274	peroxiredoxin 6	Homo sapiens	104-109
15721254-3	2005	The half-life of the HIF-1alpha subunit is determined by oxygen-dependent prolyl hydroxylation, which is required for binding of the von Hippel-Lindau protein (VHL), the recognition component of an E3 ubiquitin ligase that targets HIF-1alpha for ubiquitination and degradation.	Oxygen	57-63	von Hippel-Lindau tumor suppressor	Homo sapiens	160-163
15686361-5	2005	Herein we present the first experimental evidence to demonstrate that the NADPH/O2- and PhIO-supported P450 N-dealkylations are mechanistically distinct and, thus, the P450/PhIO system may not be a good mechanistic model for P450/NADPH/O2-catalyzed N-dealkylations.	Oxygen	80-82	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	225-235
35543285-4	2022	The SnF2 configures fluorine rich environment, which can not only suppress the oxidation of Sn2+ in synthesis, but also construct chemically stable Sn-F coordination to hinder the electron transfer from Sn2+ to oxygen within the long-term operation process.	Oxygen	211-217	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	4-8
35275632-4	2022	Kinetic investigations reveal that H-atom transfer to the metal oxide surface occurs through concerted proton-electron transfer, resulting in the formation of a transient VIII-OH2 moiety that, upon displacement of the water ligand with an acetonitrile molecule, forms the oxygen-deficient polyoxovanadate-alkoxide cluster.	Oxygen	272-278	cytochrome c oxidase subunit 8A	Homo sapiens	171-175
21166153-0	2005	[The state of SHP-1 and CD45 in lymphocyte under high partial pressure of oxygen].	Oxygen	74-80	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	14-19
35323939-2	2022	The VHL protein (pVHL) functions as part of the VCB-CR complex which plays a key role in oxygen sensing and degradation of hypoxia inducible factors.	Oxygen	89-95	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
35323939-2	2022	The VHL protein (pVHL) functions as part of the VCB-CR complex which plays a key role in oxygen sensing and degradation of hypoxia inducible factors.	Oxygen	89-95	von Hippel-Lindau tumor suppressor	Homo sapiens	17-21
35248583-3	2022	Replicating previous studies, repetition prompted reduced blood-oxygen-level-dependent (BOLD) amplitude in the anterior hippocampus and the mPFC, but not in the posterior hippocampus, due to no functional activity during mental imagery, or in the posteromedial parietal cortex, due to enhanced activation that was sustained across repetitions.	Oxygen	64-70	complement factor properdin	Mus musculus	140-144
35229496-8	2022	Japanese patients with anti-ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar-arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM-negative group.	Oxygen	116-122	angiotensin converting enzyme 2	Homo sapiens	28-32
35229496-8	2022	Japanese patients with anti-ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar-arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM-negative group.	Oxygen	151-157	angiotensin converting enzyme 2	Homo sapiens	28-32
35295995-7	2022	There were substrate-dependent alterations in the oxygen consumption rate in Wfs1KO rat muscles.	Oxygen	50-56	wolframin ER transmembrane glycoprotein	Rattus norvegicus	77-81
21166153-1	2005	AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte.	Oxygen	119-125	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	38-66
21166153-1	2005	AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte.	Oxygen	119-125	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	68-71
35249365-9	2022	DKK1 knockdown in human pulmonary artery endothelial cells cultured under hypoxic conditions decreased the cellular NADPH/NADP+ ratio, increased reactive oxygen species levels and the extent of mitochondrial DNA damage, and inhibited mitochondrial membrane hyperpolarization.	Oxygen	154-160	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	0-4
35023473-9	2022	In addition, elevated serum MMP-2 levels correlated well with the severity of sleep apnea and intermittent hypoxia, which were represented as the apnea-hypopnea index and the oxygen-desaturation index.	Oxygen	175-181	matrix metallopeptidase 2	Homo sapiens	28-33
35478774-5	2022	Overexpression of COX4-1 in the radiosensitive cells was sufficient to promote the switch from glycolytic to oxidative metabolism and the incorporation of CcO into SCs, with a concomitant reduction in O2  - production.	Oxygen	201-206	cytochrome c oxidase subunit 4I1	Homo sapiens	18-24
35478774-6	2022	Conversely, silencing of COX4-1 expression in normally radioresistant cells reduced CcO activity, promoted the disassembly of mitochondrial SCs, and increased O2  - production.	Oxygen	159-164	cytochrome c oxidase subunit 4I1	Homo sapiens	25-31
35309068-3	2022	This study aimed to examine the oxygen uptake (VO2) from VAT to RCP and its change over time in younger and older healthy adults.	Oxygen	32-38	CGRP receptor component	Homo sapiens	64-67
35625589-0	2022	Hyperbaric Oxygen Therapy Improves Parkinson"s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1alpha Pathway.	Oxygen	11-17	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	108-118
21166153-1	2005	AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte.	Oxygen	119-125	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	73-78
15585204-8	2005	Furthermore hypoxia (&lt; or =1% O2) as a further proinflammatory and especially proangiogenetic factor was able to stimulate MIF secretion by THP-1, human monocytes and HUVECs.	Oxygen	33-35	macrophage migration inhibitory factor	Homo sapiens	126-129
35557964-6	2022	Zfp580 was suppressed by combined oxygen and glucose deprivation (OGD) and mediated the effect of OGD on Igf1 and Igfbp3.	Oxygen	34-40	zinc finger protein 580	Mus musculus	0-6
34699344-3	2022	Prospective studies are needed to identify risk predictors for home oxygen(HO2) use after curative lung cancer surgery.	Oxygen	68-74	heme oxygenase 2	Homo sapiens	75-78
35269082-3	2022	By SEM, TEM, and XPS analysis of the surface of the film after atomic oxygen erosion, it was observed that atomic oxygen could cause serious oxidation on the surface of Mo/MoS2-Pb-PbS film, and the contents of MoS2, PbS, and Pb, which were lubricating components, were significantly reduced, and oxides were generated.	Oxygen	114-120	cholinergic receptor muscarinic 3	Homo sapiens	180-183
35269082-3	2022	By SEM, TEM, and XPS analysis of the surface of the film after atomic oxygen erosion, it was observed that atomic oxygen could cause serious oxidation on the surface of Mo/MoS2-Pb-PbS film, and the contents of MoS2, PbS, and Pb, which were lubricating components, were significantly reduced, and oxides were generated.	Oxygen	114-120	cholinergic receptor muscarinic 3	Homo sapiens	216-219
16403978-3	2005	As iron and oxygen are essential but potentially toxic constituents of most organisms, ROS-mediated modulation of IRP1 activity may be an important regulatory element in dissecting iron homeostasis and oxidative stress.	Oxygen	12-18	aconitase 1	Homo sapiens	114-118
35269082-4	2022	From AES analysis and the variation in the main element content, Mo/MoS2-Pb-PbS thin film showed self-protection ability in an atomic oxygen environment.	Oxygen	134-140	cholinergic receptor muscarinic 3	Homo sapiens	76-79
35220394-3	2022	Transmission electron microscopy, proximity ligation assays for mitochondrial VDAC1 and endoplasmic reticulum IP3R, and immunoanalyses of p-DRP1 and OPA1, demonstrate that low-oxygen conditions in early 1st trimester and PE promote mitochondrial fission in pMSCs.	Oxygen	176-182	voltage dependent anion channel 1	Homo sapiens	78-83
35220394-3	2022	Transmission electron microscopy, proximity ligation assays for mitochondrial VDAC1 and endoplasmic reticulum IP3R, and immunoanalyses of p-DRP1 and OPA1, demonstrate that low-oxygen conditions in early 1st trimester and PE promote mitochondrial fission in pMSCs.	Oxygen	176-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
35201977-6	2022	At the same time, ADL responsiveness to pre-synaptic input from O2-sensing neurons is heightened in qui-1, and other sensory defective mutants, resulting in enhanced neurosecretion although not increased Ca2+ responses.	Oxygen	64-66	Protein qui-1	Caenorhabditis elegans	100-105
35201977-7	2022	Expressing qui-1 selectively in ADL rescues both the qui-1 ADL neurosecretory phenotype and enhanced escape from 21% O2.	Oxygen	117-119	Protein qui-1	Caenorhabditis elegans	11-16
35394747-4	2022	Among them, the heterostructure with the largest EBI of 1.57 V attains the smallest overpotential of 97 mV at 10 mA cm-2 for the hydrogen evolution reaction and 243 mV at 50 mA cm-2 for the oxygen evolution reaction in 1 M KOH.	Oxygen	190-196	transducin beta like 1 X-linked	Homo sapiens	49-52
15589383-5	2005	We suggest that the relatively high levels of O(2)(-) in the cytosol and intermembrane space of the SOD1 mutant may react with endogenous NO, forming HOONO that can diffuse into the mitochondrial matrix and there inactivate Lys4p and other [4Fe-4S]-containing dehydratases.	Oxygen	46-50	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	100-104
35223898-9	2022	In contrast, hyperoxia remarkably reduced mPAP and PVR, indicating a preserved vasodilator response to oxygen and possibly supporting the oxygen therapy in patients with PH.	Oxygen	103-109	phospholipid phosphatase 1	Mus musculus	42-46
16159102-9	2005	With radiation or oxygen deprivation, but not oxygen-glucose deprivation, caspase 3 was activated.	Oxygen	18-24	caspase 3	Rattus norvegicus	74-83
35084406-5	2022	All these properties make the CSHS a direct Z-scheme system with the hydrogen and oxygen evolution reactions occurring, respectively, at the CdS and SnS2 layers.	Oxygen	82-88	sodium voltage-gated channel alpha subunit 11	Homo sapiens	149-153
35084406-6	2022	More encouragingly, the introduction of a S-vacancy into SnS2 could effectively lower the overpotential of the oxygen evolution reaction, thus ensuring the overall water redox reaction to be achieved spontaneously under light irradiation.	Oxygen	111-117	sodium voltage-gated channel alpha subunit 11	Homo sapiens	57-61
16271989-1	2005	Trans-sodium crocetinate (TSC), the isomer of the carotenoid compound crocetin, is found markedly to increase survival in hemorrhagic shock subsequent to 50-60% blood loss, mainly via restored resting oxygen consumption (VO(2)), blood pressure and heart rate.	Oxygen	201-207	solute carrier family 12 member 3	Rattus norvegicus	26-29
35163700-0	2022	The SDF1-CXCR4 Axis Is Involved in the Hyperbaric Oxygen Therapy-Mediated Neuronal Cells Migration in Transient Brain Ischemic Rats.	Oxygen	50-56	C-X-C motif chemokine ligand 12	Rattus norvegicus	4-8
16271989-2	2005	The proposed mechanism is that TSC increases oxygen diffusivity, and thus availability, in plasma.	Oxygen	45-51	solute carrier family 12 member 3	Rattus norvegicus	31-34
35107200-3	2022	alpha-Dioxygenases (alpha-DOXs) are heme-dependent oxidative enzymes biologically involved in the initial step of plant alpha-oxidation during which molecular oxygen is incorporated into the C alpha -position of a FA (C n ) to generate the intermediate FA hydroperoxide, which is subsequently converted into the shortened corresponding FAL (C n-1 ).	Oxygen	159-165	5'-nucleotidase, cytosolic IA	Homo sapiens	341-346
15584735-0	2004	Ligand binding properties of myoglobin reconstituted with iron porphycene: unusual O2 binding selectivity against CO binding.	Oxygen	83-85	myoglobin	Physeter catodon	29-38
35051759-6	2022	After Cd2+ treatment, HSC had reduced lactate dehydrogenase (LDH) activity and lactate production while having increased pyruvate dehydrogenase (PDH) activity, MT membrane potential, ATP production, oxygen (O2) consumption and reactive oxygen species (ROS), indicating that Cd2+ switched the pattern of energy metabolism from glycolysis to OXPHOS in HSC.	Oxygen	199-205	CD2 antigen	Mus musculus	6-9
35051759-6	2022	After Cd2+ treatment, HSC had reduced lactate dehydrogenase (LDH) activity and lactate production while having increased pyruvate dehydrogenase (PDH) activity, MT membrane potential, ATP production, oxygen (O2) consumption and reactive oxygen species (ROS), indicating that Cd2+ switched the pattern of energy metabolism from glycolysis to OXPHOS in HSC.	Oxygen	207-209	CD2 antigen	Mus musculus	6-9
35053612-2	2022	By mimicking the hematopoietic niche condition with cultures at low oxygen concentrations, we demonstrate in vitro that FLT3-ITD AML cells decrease their repopulating capacity when Vps34 is inhibited.	Oxygen	68-74	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	181-186
15584735-6	2004	The O2 affinity of the ferrous reconstituted myoglobin is 2600-fold higher than that of the wild-type, mainly due to the decrease in the O2 dissociation rate, whereas the CO affinity is not so significantly enhanced.	Oxygen	4-6	myoglobin	Physeter catodon	45-54
15584735-6	2004	The O2 affinity of the ferrous reconstituted myoglobin is 2600-fold higher than that of the wild-type, mainly due to the decrease in the O2 dissociation rate, whereas the CO affinity is not so significantly enhanced.	Oxygen	137-139	myoglobin	Physeter catodon	45-54
35021246-2	2022	Our objective was to compare the intensities of the muscle oxygen saturation breakpoint obtained with the Humon Hex and the second lactate threshold in elite cyclists.	Oxygen	59-65	hematopoietically expressed homeobox	Homo sapiens	112-115
15584735-8	2004	The ligand binding studies on H64A mutants support the fact that the slow O2 dissociation of the reconstituted myoglobin is primarily caused by the stabilization of the Fe-O2 sigma-bonding.	Oxygen	74-76	myoglobin	Physeter catodon	111-120
15584735-10	2004	The high O2 affinity and the unique characteristics of the myoglobin with the iron porphycene indicate that reconstitution with a synthesized heme is a useful method not only to understand the physiological function of myoglobin but also to create a tailor-made function on the protein.	Oxygen	9-11	myoglobin	Physeter catodon	219-228
15576492-6	2004	In support of a hypoxia-induced increase of BNP gene transcription, the content of a premature BNP mRNA was increased in hypoxic myocardium (4.8-fold, P&lt;0.005) and in freshly harvested ventricular myocytes when kept in culture flasks and oxygen-deprived for 3 h (2.2-fold, P=0.002).	Oxygen	241-247	natriuretic peptide B	Homo sapiens	44-47
35006382-3	2022	Here, using oxygen-induced retinopathy (OIR) mice, a surrogate model of ROP, we quantified an exclusive binding of Scg3 to diseased versus healthy developing neovessels that contrasted sharply with the ubiquitous binding of VEGF.	Oxygen	12-18	secretogranin III	Mus musculus	115-119
15576492-6	2004	In support of a hypoxia-induced increase of BNP gene transcription, the content of a premature BNP mRNA was increased in hypoxic myocardium (4.8-fold, P&lt;0.005) and in freshly harvested ventricular myocytes when kept in culture flasks and oxygen-deprived for 3 h (2.2-fold, P=0.002).	Oxygen	241-247	natriuretic peptide B	Homo sapiens	95-98
15642323-9	2004	Furthermore, Sod2-deficient cells showed dramatic mitochondrial damage, cytochrome C leakage, caspase 3 activation and increased apoptotic cell death when they were challenged with O2-.	Oxygen	181-183	superoxide dismutase 2	Homo sapiens	13-17
15545830-1	2004	Previous studies have shown that administering trans-sodium crocetinate (TSC) as a treatment of hemorrhagic shock leads to increased whole-body oxygen consumption and survival as well as protection of the liver and kidney.	Oxygen	144-150	solute carrier family 12 member 3	Rattus norvegicus	73-76
15545830-2	2004	It has been suggested that TSC increases oxygen delivery by increasing the diffusivity of oxygen through plasma.	Oxygen	41-47	solute carrier family 12 member 3	Rattus norvegicus	27-30
15545830-2	2004	It has been suggested that TSC increases oxygen delivery by increasing the diffusivity of oxygen through plasma.	Oxygen	90-96	solute carrier family 12 member 3	Rattus norvegicus	27-30
15545830-12	2004	These results support the hypothesis that the effects of TSC on hemorrhagic shock are mediated via an effect on oxygen.	Oxygen	112-118	solute carrier family 12 member 3	Rattus norvegicus	57-60
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	170-172	cytochrome c oxidase subunit 8A	Homo sapiens	215-233
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	170-172	cytochrome c oxidase subunit 8A	Homo sapiens	235-238
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	170-172	cytochrome c oxidase subunit 8A	Homo sapiens	388-391
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	170-172	cytochrome c oxidase subunit 8A	Homo sapiens	388-391
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	314-316	cytochrome c oxidase subunit 8A	Homo sapiens	215-233
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	314-316	cytochrome c oxidase subunit 8A	Homo sapiens	235-238
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	314-316	cytochrome c oxidase subunit 8A	Homo sapiens	215-233
15546991-1	2004	The detailed molecular mechanism for the reversible inhibition of mitochondrial respiration by NO has puzzled investigators: The rate constants for the binding of NO and O2 to the reduced binuclear center CuB/a3 of cytochrome oxidase (COX) are similar, and NO is able to dissociate slowly from this center whereas O2 is kinetically trapped, which altogether seems to favor the complex of COX with O2 over the complex of COX with NO.	Oxygen	314-316	cytochrome c oxidase subunit 8A	Homo sapiens	235-238
15546991-2	2004	Paradoxically, the inhibition of COX by NO is observed at high ratios of O2 to NO (in the 40-500 range) and is very fast (seconds or faster).	Oxygen	73-75	cytochrome c oxidase subunit 8A	Homo sapiens	33-36
15546991-4	2004	The results showed that all known features of the inhibition of COX by NO can be accounted for by a direct competition between NO and O2 for the reduced binuclear center CuB/a3 of COX.	Oxygen	134-136	cytochrome c oxidase subunit 8A	Homo sapiens	64-67
15546991-4	2004	The results showed that all known features of the inhibition of COX by NO can be accounted for by a direct competition between NO and O2 for the reduced binuclear center CuB/a3 of COX.	Oxygen	134-136	cytochrome c oxidase subunit 8A	Homo sapiens	180-183
15322079-4	2004	In one structure obtained under reducing conditions, the iron-bridging ligand Glu-267 adopts the mu-(eta1,eta2) coordination mode, which has previously been related to O2 activation, and an acetate ion from the soaking solution is observed where O2 has been proposed to bind the iron.	Oxygen	168-170	secreted phosphoprotein 1	Mus musculus	101-105
15715285-3	2004	It appears that in vitro production of active oxygen forms by blood neutrophils at high pressures can be sustained provided increased concentrations of Mg2+ in the incubating medium.	Oxygen	46-52	mucin 7, secreted	Homo sapiens	152-155
15474027-1	2004	Hypoxia-inducible factor (HIF) is a transcriptional complex that is regulated by oxygen sensitive hydroxylation of its alpha subunits by the prolyl hydroxylases PHD1, 2 and 3.	Oxygen	81-87	egl-9 family hypoxia inducible factor 2	Homo sapiens	161-174
15525582-2	2004	During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development, and GLUT1 expression is enhanced in response to oxygen deficiency in the placenta.	Oxygen	185-191	solute carrier family 2 member 1	Rattus norvegicus	141-146
35388756-1	2022	BACKGROUND: Parkinson"s disease (PD) is associated with coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) downregulation, which has been linked to reduced cyclocytase activity and increased levels of oxygen free radicals, leading to mitochondrial fragmentation and apoptosis.	Oxygen	215-221	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	56-111
35388756-1	2022	BACKGROUND: Parkinson"s disease (PD) is associated with coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) downregulation, which has been linked to reduced cyclocytase activity and increased levels of oxygen free radicals, leading to mitochondrial fragmentation and apoptosis.	Oxygen	215-221	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	113-119
15525582-5	2004	GLUT1 mRNA and protein expression were elevated under 5% O2 or in the presence of cobalt chloride, which has been shown to mimic hypoxia.	Oxygen	57-59	solute carrier family 2 member 1	Rattus norvegicus	0-5
15525582-7	2004	Deletion mutant analysis of the rGLUT1 promoter indicated that a 184 bp hypoxia-responsive element (HRE) of the promoter was essential to increase GLUT1 reporter gene expression in response to low-oxygen conditions.	Oxygen	197-203	solute carrier family 2 member 1	Rattus norvegicus	32-38
35379776-7	2022	Finally, we found that TMAO markedly induced the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) and production of reactive oxygen species, which contributed to PRMT5 expression and subsequent VCAM-1 expression.	Oxygen	151-157	protein arginine N-methyltransferase 5	Mus musculus	188-193
15525582-7	2004	Deletion mutant analysis of the rGLUT1 promoter indicated that a 184 bp hypoxia-responsive element (HRE) of the promoter was essential to increase GLUT1 reporter gene expression in response to low-oxygen conditions.	Oxygen	197-203	solute carrier family 2 member 1	Rattus norvegicus	33-38
15327892-1	2004	Human B19 erythrovirus replicates in erythroid progenitors present in bone marrow and fetal tissues where partial oxygen tension is low.	Oxygen	114-120	eva-1 homolog C	Homo sapiens	6-9
35343597-9	2022	High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non-invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9).	Oxygen	10-16	EP300 interacting inhibitor of differentiation 1	Homo sapiens	76-81
35343597-9	2022	High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non-invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9).	Oxygen	10-16	EP300 interacting inhibitor of differentiation 1	Homo sapiens	175-180
35343597-9	2022	High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non-invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9).	Oxygen	10-16	olfactory receptor family 2 subfamily Y member 1	Homo sapiens	242-248
15327892-3	2004	Hypoxia-inducible factor-1 (HIF-1), the main transcription factor involved in the cellular response to reduced oxygenation, is shown to bind an HIF binding site (HBS) located in the distal part of the B19 promoter region, but the precise mechanism involved in the oxygen-sensitive upregulation of viral gene expression remains to be elucidated.	Oxygen	111-117	eva-1 homolog C	Homo sapiens	201-204
15302574-4	2004	Decreasing oxygen concentrations cause strong attenuation of PEDF release resulting in enhanced VEGF/PEDF ratios.	Oxygen	11-17	serpin family F member 1	Homo sapiens	61-65
35475886-9	2022	Conclusions: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.	Oxygen	89-95	microRNA 34a	Homo sapiens	67-76
15302574-4	2004	Decreasing oxygen concentrations cause strong attenuation of PEDF release resulting in enhanced VEGF/PEDF ratios.	Oxygen	11-17	serpin family F member 1	Homo sapiens	101-105
17191905-0	2004	Electroreduction of oxygen by cytochrome C oxidase immobilized in electrode-supported lipid bilayer membranes.	Oxygen	20-26	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	30-50
35287982-12	2022	CONCLUSIONS: Both the B52 and 52 combinations infrequently required repeat agitation medication; however, the B52 combination resulted in more oxygen desaturation, hypotension, physical restraint use, and longer length of stay.	Oxygen	143-149	serine and arginine rich splicing factor 6	Homo sapiens	110-113
35348035-0	2022	Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period.	Oxygen	126-132	growth associated protein 43	Rattus norvegicus	20-48
35411223-7	2022	Scanning electron microscopy and fluorescent imaging (Lox-1 probe) showed the presence of an extracellular matrix and the installation of an oxygen gradient leading to the formation of a hypoxic area during growth.	Oxygen	141-147	oxidized low density lipoprotein receptor 1	Homo sapiens	54-59
17191905-1	2004	Cytochrome c oxidase is the terminal enzyme in mammalian respiration, and one of its main functions is to catalyze the reduction of oxygen under physiological conditions.	Oxygen	132-138	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
34999037-9	2022	Furthermore, CAIX inhibition caused changes in pH balance, disruption in organelle integrity of mitochondria, and increase intracellular reactive oxygen level of HeLa cells.	Oxygen	146-152	carbonic anhydrase 9	Homo sapiens	13-17
17191905-3	2004	In this work, bovine cytochrome c oxidase has been immobilized in electrode-supported lipid bilayer membranes to investigate the electroreduction of oxygen under flow conditions.	Oxygen	149-155	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	21-41
17191905-10	2004	The cytochrome c oxidase-modified electrodes described here could potentially be used for the direct electroreduction of oxygen to water in a biofuel cell.	Oxygen	121-127	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	4-24
35104247-4	2022	Endothelial-specific deletion of Flrt2 in mice selectively pruned abnormalized vessels, resulting in a unique metabolic state termed "oxygen-glucose uncoupling", which suppresses tumor metastasis.	Oxygen	134-140	fibronectin leucine rich transmembrane protein 2	Mus musculus	33-38
15343513-3	2004	Encoded pVHL aids degradation of hypoxia-inducible factors (HIFs) in the presence of normal oxygen levels.	Oxygen	92-98	von Hippel-Lindau tumor suppressor	Homo sapiens	8-12
35247316-0	2022	The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.	Oxygen	78-84	von Hippel-Lindau tumor suppressor	Homo sapiens	61-65
35247316-2	2022	However, the known oxygen-sensing mechanism in mammalian cells depends on pVHL, which is only found among metazoans but not in other species.	Oxygen	19-25	von Hippel-Lindau tumor suppressor	Homo sapiens	74-78
35247316-6	2022	Bioinformatic analysis of human tumor data reveals that the ATE1/UBR and pVHL pathways jointly regulate oxygen sensing in a transcription-independent manner with different tissue specificities.	Oxygen	104-110	von Hippel-Lindau tumor suppressor	Homo sapiens	73-77
15307133-6	2004	Explants under TNFalpha and 17% O2 revealed progressive degeneration of syncytiotrophoblast (ST) followed by restoration of hCG, localized to newly differentiated cytotrophoblasts.	Oxygen	32-34	hypertrichosis 2 (generalised, congenital)	Homo sapiens	124-127
35308416-7	2022	Results: Results showed a significant inverse relationship between the levels of Ang 1-7 and the severity of the disease (needed oxygen, intubation, and mechanical ventilation).	Oxygen	129-135	angiopoietin 1	Homo sapiens	81-88
35308416-8	2022	According to the results, median (interquartile range) of Ang (1-7) levels was significantly lower in patients who needed oxygen versus those who needed no oxygen (44.50 (91) vs. 82.25 (68), p = 0.002), patients who needed intubation and mechanical ventilation versus those who did not (9.80 (62) vs. 68.70 (102), p < 0.000) and patients hospitalized in an intensive care unit (ICU) than people hospitalized in other wards.	Oxygen	122-128	angiopoietin 1	Homo sapiens	58-66
35308416-8	2022	According to the results, median (interquartile range) of Ang (1-7) levels was significantly lower in patients who needed oxygen versus those who needed no oxygen (44.50 (91) vs. 82.25 (68), p = 0.002), patients who needed intubation and mechanical ventilation versus those who did not (9.80 (62) vs. 68.70 (102), p < 0.000) and patients hospitalized in an intensive care unit (ICU) than people hospitalized in other wards.	Oxygen	156-162	angiopoietin 1	Homo sapiens	58-66
15282454-13	2004	Control of thrombin formation during reperfusion may be a feasible approach to improve oxygen delivery to reperfused vascular beds.	Oxygen	87-93	coagulation factor II, thrombin	Sus scrofa	11-19
35321000-12	2022	After administration of ordinary oxygen therapy, HR (t = 18.2, P <= 0.05), RR (t = 10.8, P <= 0.05), MAP (t = 13.1, P <= 0.05), PaCO2 (t = 15.8, P <= 0.05), Lac (t = 7.1, P <= 0.05), and NT-proBNP (t = 10, P <= 0.05) were significantly lower than before.	Oxygen	33-39	lactase	Homo sapiens	157-160
15014154-5	2004	Furthermore, the correspondent sites to these selected codons were collectively located at two planes in the crystallographic structure of rabbit transferrin, which suggested that the rapid evolution of C. auratus transferrin might correlate to its adaptation to variable environmental elements such as oxygen pressure.	Oxygen	303-309	serotransferrin	Oryctolagus cuniculus	146-157
35350383-7	2022	In vitro, overexpression of GHR in chicken BMSCs increased mitochondrial membrane potential but decreased reactive oxygen and ATP contents, oxidative phosphorylation complex enzyme activity, and mitochondrial number.	Oxygen	115-121	growth hormone receptor	Gallus gallus	28-31
15014154-5	2004	Furthermore, the correspondent sites to these selected codons were collectively located at two planes in the crystallographic structure of rabbit transferrin, which suggested that the rapid evolution of C. auratus transferrin might correlate to its adaptation to variable environmental elements such as oxygen pressure.	Oxygen	303-309	serotransferrin	Oryctolagus cuniculus	214-225
15210106-1	2004	New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2.	Oxygen	159-165	siah E3 ubiquitin protein ligase 1	Homo sapiens	267-273
35237934-10	2022	The lack of UCP3 makes the heart more prone to oxidative insult by reducing oxygen consumption and increasing ROS.	Oxygen	76-82	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	12-16
15210106-1	2004	New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2.	Oxygen	159-165	siah E3 ubiquitin protein ligase 2	Homo sapiens	278-283
35156537-0	2022	Ribophorin II promotes the epithelial-mesenchymal transition and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol-3-Kinase/Protein Kinase B activation.	Oxygen	145-151	ribophorin II	Homo sapiens	0-13
15210106-1	2004	New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2.	Oxygen	167-169	siah E3 ubiquitin protein ligase 1	Homo sapiens	267-273
35415275-3	2022	Prolyl hydroxylase domain (PHD) homologs 1-3 (PHD1/2/3) are molecular oxygen dependent non-heme dioxygenases whose enzymatic activity is regulated by the concentration of dissolved oxygen.	Oxygen	70-76	egl-9 family hypoxia inducible factor 2	Homo sapiens	46-54
15210106-1	2004	New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2.	Oxygen	167-169	siah E3 ubiquitin protein ligase 2	Homo sapiens	278-283
35415275-3	2022	Prolyl hydroxylase domain (PHD) homologs 1-3 (PHD1/2/3) are molecular oxygen dependent non-heme dioxygenases whose enzymatic activity is regulated by the concentration of dissolved oxygen.	Oxygen	181-187	egl-9 family hypoxia inducible factor 2	Homo sapiens	46-54
35296074-4	2022	In addition to regulating cytokine and chemokine expression through activation of redox sensitive transcription factors, APE1 participates in other critical processes in the immune response, including production of reactive oxygen species and class switch recombination.	Oxygen	224-230	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	121-125
35264952-0	2022	Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition.	Oxygen	93-99	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	70-74
15160393-0	2004	Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase.	Oxygen	31-37	nitric oxide synthase 1	Homo sapiens	0-12
35205407-2	2022	VHL is involved, through the EPO-VHL-HIF signaling axis, in oxygen sensing and adaptive response to hypoxia, as well as in numerous HIF-independent pathways.	Oxygen	60-66	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
15155905-3	2004	Mice devoid of the corepressor protein RIP140 are lean, show resistance to high-fat diet-induced obesity and hepatic steatosis, and have increased oxygen consumption.	Oxygen	147-153	nuclear receptor interacting protein 1	Mus musculus	39-45
35144597-10	2022	Pathological angiogenesis in DIXDC1 knockout mice was decreased significantly in oxygen-induced retinopathy (OIR) and in wound healing models.	Oxygen	81-87	DIX domain containing 1	Mus musculus	29-35
15039019-8	2004	Finally, AE1 was stimulated by oxygenation in HbA cells, but this stimulation by O2 was absent in HbS cells and pink ghosts prepared from HbA cells.	Oxygen	81-83	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	9-12
35431436-7	2022	The vacancy ordering at delta = 0.5 is different from the widely reported structure and involves oxygen sites in both CoO2 and LaO planes.	Oxygen	97-103	interleukin 4 induced 1	Homo sapiens	127-130
15099082-1	2004	The economy of dioxygen consumption by enzymes constitutes a fundamental problem in enzymatic chemistry (ref 1).	Oxygen	15-23	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	105-110
34991782-6	2022	Peroxidase (POD), polyphenol oxidase (PPO), and superoxide dismutase (SOD) activities significantly increased by SNP and NaHS treatment, and indoleacetic acid oxidase (IAAO) activity and the O2- and H2O2 content significantly decreased by SNP and NaHS treatment.	Oxygen	191-193	peroxidase	Solanum lycopersicum	0-10
34991782-6	2022	Peroxidase (POD), polyphenol oxidase (PPO), and superoxide dismutase (SOD) activities significantly increased by SNP and NaHS treatment, and indoleacetic acid oxidase (IAAO) activity and the O2- and H2O2 content significantly decreased by SNP and NaHS treatment.	Oxygen	191-193	peroxidase	Solanum lycopersicum	12-15
15099082-2	2004	Sometimes, the enzyme converts ALL the oxygen into water, without affecting the organic substrate, thereby acting as an "oxidase" (ref 1).	Oxygen	39-45	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	120-136
15064408-3	2004	Data presented here are consistent with a previously uncharacterized function for CCS in the SOD1 pathway, namely mediating enzyme activation in response to increases in oxygen tension.	Oxygen	170-176	copper chaperone for superoxide dismutase	Homo sapiens	82-85
35088561-8	2022	Mfn2, a target of miR-195, was found to be downregulated and was associated with increased mitochondrial production of reactive oxygen species during beta-cell dedifferentiation.	Oxygen	128-134	mitofusin 2	Mus musculus	0-4
15064408-6	2004	This CCS function provides oxidant-responsive posttranslational regulation of SOD1 activity and may be relevant to a wide array of physiological stresses that involve a sudden elevation of oxygen availability.	Oxygen	189-195	copper chaperone for superoxide dismutase	Homo sapiens	5-8
15048578-1	2004	Myoglobin plays various roles in oxygen supply to muscle mitochondria.	Oxygen	33-39	myoglobin	Rattus norvegicus	0-9
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	30-36	colony stimulating factor 1 receptor	Homo sapiens	269-274
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	98-104	colony stimulating factor 1 receptor	Homo sapiens	269-274
15048578-7	2004	The results show that it is possible to use serial sections for the determination of the myoglobin concentration and succinate dehydrogenase activity, and indicate that myoglobin can lead to a substantial reduction (18-60%) of the extracellular oxygen tension required to prevent an anoxic core in muscle cells.	Oxygen	245-251	myoglobin	Rattus norvegicus	169-178
15052191-9	2004	Increase of total mucin (MUC5AC, MUC5B, and MUC2) during cardiopulmonary bypass showed positive correlation with DNA increase during cardiopulmonary bypass (r = 0.73), PaCO(2) (r = 0.62) and alveolar-arterial oxygen difference (r = 0.55) immediately after cardiopulmonary bypass.	Oxygen	209-215	LOC100508689	Homo sapiens	18-23
35045880-15	2022	The maximum oxygen consumption rate (OCR), ATP and lipid-related genes acc, fasn, and acadm were found to be positively correlated with TFEB/ERRalpha.	Oxygen	12-18	transcription factor EB	Homo sapiens	136-140
14694147-5	2004	XOR requires molybdopterin, iron-sulphur centres, and FAD as cofactors and has two interconvertible forms, xanthine oxidase and xanthine dehydrogenase, which transfer electrons from xanthine to oxygen and NAD(+), respectively, yielding superoxide, hydrogen peroxide and NADH.	Oxygen	194-200	xanthine dehydrogenase	Homo sapiens	0-3
14694147-5	2004	XOR requires molybdopterin, iron-sulphur centres, and FAD as cofactors and has two interconvertible forms, xanthine oxidase and xanthine dehydrogenase, which transfer electrons from xanthine to oxygen and NAD(+), respectively, yielding superoxide, hydrogen peroxide and NADH.	Oxygen	194-200	xanthine dehydrogenase	Homo sapiens	128-150
34931659-3	2022	Exposing 5 days post-fertilization (dpf) larvae to 10% dissolved O2 (DO) for 16 h only marginally reduced survival, but it decreased forebrain neural proliferation by 55%, and reduced the expression of neurod1, gfap, and mbpa, markers of determined neurons, glia, and oligodendrocytes, respectively.	Oxygen	65-67	glial fibrillary acidic protein	Danio rerio	211-215
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	34-40	C-X-C motif chemokine ligand 2	Rattus norvegicus	129-134
35052472-2	2022	Mutations in the genes coding the alpha and beta globin chains (HBA1, HBA2 and HBB) strengthen the binding of oxygen to hemoglobin (Hb), bringing about tissue hypoxia and a secondary erythrocytosis.	Oxygen	110-116	hemoglobin subunit alpha 1	Homo sapiens	64-68
35052472-2	2022	Mutations in the genes coding the alpha and beta globin chains (HBA1, HBA2 and HBB) strengthen the binding of oxygen to hemoglobin (Hb), bringing about tissue hypoxia and a secondary erythrocytosis.	Oxygen	110-116	hemoglobin subunit alpha 2	Homo sapiens	70-74
35041273-1	2022	Designing an efficient and durable electrocatalyst for the sluggish oxygen evolution reaction (OER) at the anode remains the foremost challenge in developing proton exchange membrane (PEM) electrolyzers.	Oxygen	68-74	mucin 1, cell surface associated	Homo sapiens	184-187
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	42-44	C-X-C motif chemokine ligand 2	Rattus norvegicus	129-134
35223039-6	2022	Electrode polarization was therefore used to control defect concentrations and to extract concentration amended activation energies, which prove to be drastically different for oxygen incorporation and evolution (0.26 vs. 2.05 eV for LSF).	Oxygen	177-183	transcription factor CP2	Homo sapiens	234-237
14982453-6	2004	The structure of the transition state confirms that human thymidine phosphorylase proceeds through an S(N)2-like transition state with bond orders of 0.50 to the thymine leaving group and 0.33 to the attacking oxygen nucleophile.	Oxygen	210-216	thymidine phosphorylase	Homo sapiens	58-81
14583436-2	2004	pVHL binding to HIF-1alpha is lost under low O2 tension, leading to transcription of several genes involved in the hypoxia response.	Oxygen	45-47	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
15777013-2	2004	For example, most species lack glutathione peroxidase, glutathione reductase and respiratory-gas transport proteins and thus allow oxygen to diffuse directly into cells.	Oxygen	131-137	glutathione-disulfide reductase	Homo sapiens	55-76
15319539-1	2004	Hypoxia-inducible factor (HIF) alpha subunits are induced under hypoxic conditions, when limited oxygen supply prevents prolyl hydroxylation-dependent binding of the ubiquitin ligase pVHL and subsequent proteasomal degradation.	Oxygen	97-103	von Hippel-Lindau tumor suppressor	Homo sapiens	183-187
14686923-4	2004	The two other oxygen-evolving complex (OEC) proteins, PsbP and PsbQ, were completely lacking in Delta psbL.	Oxygen	14-20	oxygen-evolving enhancer protein 3-2, chloroplastic-like	Nicotiana tabacum	63-67
14734056-15	2004	- Oxygen and substrate wasting in CLP occurs with fewer mitochondria and energy deficit, processes that are coincident with caspase-3 activation.	Oxygen	2-8	caspase 3	Rattus norvegicus	124-133
14673090-1	2003	Mitochondrial cytochrome c oxidase plays an essential role in aerobic cellular respiration, reducing dioxygen to water in a process coupled with the pumping of protons across the mitochondrial inner membrane.	Oxygen	101-109	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	14-34
14687423-8	2003	CONCLUSIONS: These results suggest that above a certain level of neuronal activity, a regulatory mechanism between regional cerebral blood flow (rCBF) and rCBV acts to prevent excess O2 inflow into the focally activated area.	Oxygen	183-185	CCAAT/enhancer binding protein zeta	Rattus norvegicus	145-149
14658876-7	2003	In the presence of excess vinyltrimethylsilane (vtms), Ag2O and Hhfac form [Ag3(hfac)3(vtms)]infinity, 4, which contains trimetallic subunits assembled via oxygen atoms of bridging hfac ligands and 5- and 6-coordinate silver.	Oxygen	156-162	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	76-79
13129920-8	2003	There was three times more insoluble protein in HEK-v than in HEK-dtps1 after 3 days of exposure to low O2.	Oxygen	104-106	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	66-71
14664716-1	2003	Previous studies have shown that the expression of the major components from a local pancreatic renin-angiotensin system (RAS) was upregulated after chronic exposure to oxygen deprivation (10% oxygen).	Oxygen	169-175	renin	Rattus norvegicus	96-101
14664716-1	2003	Previous studies have shown that the expression of the major components from a local pancreatic renin-angiotensin system (RAS) was upregulated after chronic exposure to oxygen deprivation (10% oxygen).	Oxygen	193-199	renin	Rattus norvegicus	96-101
14674329-8	2003	In severely hypoxemic patients with COPD long-term domicillary oxygen therapy improves the survival rate.	Oxygen	63-69	COPD	Homo sapiens	36-40
14555671-8	2003	A single HBO treatment (100% oxygen, 3 ATA for 1 h) 1 h after hypoxia reduced the enhanced caspase-3 expression and activity, attenuated the PARP cleavage, and decreased the number of TUNEL-positive cells observed in the cortex and hippocampus.	Oxygen	29-35	caspase 3	Rattus norvegicus	91-100
14569079-3	2003	This review summarizes the current knowledge of the molecular pathogenesis of von Hippel-Lindau disease and the role of the VHL gene product (pVHL) in kidney cancer and the mammalian oxygen sensing pathway.	Oxygen	183-189	von Hippel-Lindau tumor suppressor	Homo sapiens	142-146
12966547-2	2003	As a consequence, the production of the oxygen radical scavenger manganese superoxide dismutase (MnSOD) is increased.	Oxygen	40-46	superoxide dismutase 2	Homo sapiens	97-102
14586884-4	2003	These parameters include the effect of changes in oxyhemoglobin dissociation curve (ODC; expressed by P(50)) on oxygen availability, under the different circumstances occurring during liver transplantation.	Oxygen	112-118	ornithine decarboxylase 1	Homo sapiens	84-87
14586884-11	2003	The intraoperative changes in P(50) values, which represent a shift of the ODC to the left, may reflect a more accurate estimation of O(2) release to the tissues, than the hemoglobin, Pao(2) and Sao(2) alone.	Oxygen	134-138	ornithine decarboxylase 1	Homo sapiens	75-78
14586884-12	2003	Besides conventional hemodynamic parameters, P(50), which includes the effect of alterations in ODC on oxygen availability, could be of value in monitoring the systemic oxygenation during liver transplantation.	Oxygen	103-109	ornithine decarboxylase 1	Homo sapiens	96-99
12902323-3	2003	The imidazole ring of His291-alpha in E1b coordinates to the terminal phosphate oxygen atoms of bound ThDP.	Oxygen	80-86	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	38-41
12975333-11	2003	A mechanism for the p450-mediated ring scission is proposed in which the isoxazole ring nitrogen or oxygen coordinates to the reduced form of the heme followed by charge transfer from p450Fe(II) to the C=N bond or deprotonation of the C3-H, which results in a cleavage of the N-O bond.	Oxygen	100-106	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	20-24
12970147-7	2003	Moreover, in multiple regression analysis, proBNP and BNP were also related to arterial carbon dioxide and oxygen tensions.	Oxygen	107-113	natriuretic peptide B	Homo sapiens	46-49
14568476-5	2003	Oxygen metabolism was increased in the GP and SMA (supplementary motor area including premotor cortex, Fig.	Oxygen	0-6	survival of motor neuron 1, telomeric	Homo sapiens	46-49
12958623-5	2003	Active oxygen species sustained the increased MMP-9 activity for at least 24 h. In the post-hypoxic period 20 micro mol/L H(2)O(2) caused a 6-fold increase in the specific activity of MMP-9 over the normoxic cells and a comparable effect was exerted by thrombin (50 nmol/L) and leukocyte elastase (10 nmol/L).	Oxygen	7-13	elastase, neutrophil expressed	Homo sapiens	278-296
12864746-9	2003	By targeting the UCP2-gene there was no effect on whole body energy metabolism, but instead, a reduced ability to protect against free-radical oxygen species.	Oxygen	143-149	uncoupling protein 2	Homo sapiens	17-21
12869192-9	2003	In CDK2, each of the four bromine atoms makes polar contacts either to main chain oxygens in the hinge region of the kinase or to water molecules, in addition to several van der Waals contacts.	Oxygen	82-89	cyclin dependent kinase 2	Homo sapiens	3-7
12858170-4	2003	In cultured cortical neurons, UCP-2 reduced cell death and inhibited caspase-3 activation induced by oxygen and glucose deprivation.	Oxygen	101-107	uncoupling protein 2	Homo sapiens	30-35
12663441-3	2003	We here describe that Ang II highly stimulates endogenous and extracellular O2- production in these cells, consistent with the translocation to the cell membrane of the cytosolic components of NADPH oxidase, p47phox, and p67phox.	Oxygen	76-78	neutrophil cytosolic factor 2	Homo sapiens	221-228
12626334-6	2003	CGRP and RAMP1 ASODNs raised PPA in normoxic rats briefly exposed to 10% O2 above MMODN and saline controls.	Oxygen	73-75	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
12738801-0	2003	Oxygen-regulated expression of the Wilms" tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1).	Oxygen	0-6	WT1 transcription factor	Rattus norvegicus	59-62
12738801-4	2003	We show here that Wt1 mRNA and protein is up-regulated in the heart and kidneys of rats exposed to normobaric hypoxia (8% O2).	Oxygen	122-124	WT1 transcription factor	Rattus norvegicus	18-21
12796152-9	2003	Significant increase in exercise capacity was found in response to EXT: (1) peak work rate (WR), O(2), CO(2), E, tidal volume (VT), and heart rate increased, while peak exertional dyspnea and leg effort did not significantly change; (2) exertional dyspnea/O(2) and exertional dyspnea/CO(2) decreased while E/O(2) and E/CO(2) remained unchanged.	Oxygen	97-101	exostosin glycosyltransferase 1	Homo sapiens	67-70
12697836-6	2003	Caki-1 cells were exposed to hypoxia (1% O2) and exhibited increased Cdc42, Rac1 and RhoA protein expression.	Oxygen	41-43	cell division cycle 42	Homo sapiens	69-74
12740438-0	2003	Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants.	Oxygen	126-132	aldehyde dehydrogenase 5F1	Arabidopsis thaliana	14-49
12663485-4	2003	Hypoxia (0% O2 for 18 hours) induced a 2-fold increase of Ecto-5"-Nucleotidase activity (Vmax 19.78+/-0.53 versus 8.82+/-1.12 nmol/mg protein per min), whereas mRNA abundance and total amount of the protein were unmodified.	Oxygen	12-14	5'-nucleotidase ecto	Homo sapiens	58-78
12588875-2	2003	The transactivation activity of HIF complexes requires the recruitment of p300/CREB-binding protein (CBP) by HIF-1 alpha and HIF-2 alpha that undergo oxygen-dependent degradation.	Oxygen	150-156	E1A binding protein p300	Homo sapiens	74-78
12551918-4	2003	Although both p42/44 MAPK and p38 MAPK were activated rapidly in cells stimulated with BzATP, only pharmacological inhibition of p38 MAPK attenuated O(2)(-)* production.	Oxygen	149-153	mitogen-activated protein kinase 14	Mus musculus	129-137
2554973-2	1989	The superhyperfine structure of Cat1 contained in liposomes was found to be sensitive to oxygen concentration in a fashion similar to that of free Cat1.	Oxygen	89-95	GIT ArfGAP 1	Homo sapiens	32-36
12686129-0	2003	A theoretical study of the dioxygen activation by glucose oxidase and copper amine oxidase.	Oxygen	27-35	amine oxidase copper containing 3	Homo sapiens	70-90
16667152-0	1989	Oxygen Inhibition of Nitrate Reductase Biosynthesis in Detached Corn Leaves via Inhibition of Total Soluble Protein Synthesis.	Oxygen	0-6	nitrate reductase [NADH] 1	Zea mays	21-38
16667152-4	1989	NADH:nitrate reductase mRNA levels were the same in the air-and O(2)-treated leaves.	Oxygen	64-68	nitrate reductase [NADH] 1	Zea mays	5-22
12686129-1	2003	Glucose oxidase (GO) and copper amine oxidase (CAO) catalyze the reduction of molecular oxygen to hydrogen peroxide.	Oxygen	88-94	amine oxidase copper containing 3	Homo sapiens	25-45
16667152-6	1989	Incorporation of [(35)S]methionine during nitrate treatment revealed that total soluble protein and nitrate reductase protein synthesis were both depressed by the O(2) environment relative to air, but both recovered when leaves were shifted from O(2) to air.	Oxygen	163-167	nitrate reductase [NADH] 1	Zea mays	100-117
16667152-7	1989	Although O(2) accelerated inactivation of nitrate reductase in vitro, the in vivo inactivation rate appeared to be too low to account for the depressed level of nitrate reductase activity in O(2)-treated leaves.	Oxygen	9-13	nitrate reductase [NADH] 1	Zea mays	42-59
12686129-1	2003	Glucose oxidase (GO) and copper amine oxidase (CAO) catalyze the reduction of molecular oxygen to hydrogen peroxide.	Oxygen	88-94	amine oxidase copper containing 3	Homo sapiens	47-50
12686129-2	2003	If a closed-shell cofactor (like FADH(2) in GO and topaquinone (TPQ) in CAO) is electron donor in dioxygen reduction, the formation of a closed-shell species (H(2)O(2)) is a spin forbidden process.	Oxygen	98-106	amine oxidase copper containing 3	Homo sapiens	72-75
12686139-3	2003	Here we construct unambiguous connection diagrams that describe the interactions among the three non-ester phosphate oxygen atoms of PLP and surrounding atoms from the protein binding site and from water molecules, the so-called phosphate group binding "cup".	Oxygen	117-123	pyridoxal phosphatase	Homo sapiens	133-136
2584778-14	1989	In vitro studies revealed that human immunoglobulin denatured by O2 bubbling produced C4a, C3a, and C5a in a dose dependent manner, although human albumin treated identically as human immunoglobulin did not produce them.	Oxygen	65-67	complement C4A (Rodgers blood group)	Homo sapiens	86-89
12656610-0	2003	Oxygen equilibrium properties of myoglobin locked in the liganded and unliganded conformations.	Oxygen	0-6	myoglobin	Physeter catodon	33-42
12725383-2	2003	The data obtained from measurements made on analytes prepared in the laboratory, as well as those made on real samples (some commercial orange drinks, flash of the fresh fruits) point to the redox reaction of L-ascorbic acid (L-AH2) being very sensitive to both the presence of dissolved gaseous species (O2, CO2) and the ionic strenght in the analyte.	Oxygen	305-307	lipase H	Homo sapiens	226-231
2764404-6	1989	MEASUREMENTS AND MAIN RESULTS: Radial artery catheter blood oxygen tension in the patients declined from a ground value (PaO2G) at sea level of 72.4 +/- 9 mm Hg to an altitude value (PaO2Alt) of 47.4 +/- 6 mm Hg after 45 minutes of steady state hypobaric exposure.	Oxygen	60-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	131-134
12615973-10	2003	Endogenous PHD2mRNA and PHD3mRNA were hypoxia-inducible, whereas expression of PHD1mRNA and FIH-1mRNA was oxygen independent.	Oxygen	106-112	egl-9 family hypoxia inducible factor 2	Homo sapiens	79-83
12962322-12	2003	We propose that the lowered oxygen affinity of Tg-HbP in the presence of allosteric effectors is a consequence of an altered R-state conformation of Hb, which reflects the facilitation of switching the R-state of HbP to the T-state compared with the normal R-state of HbA, thereby reducing HbA"s affinity to oxygen.	Oxygen	28-34	heme binding protein 1	Homo sapiens	50-53
12962322-12	2003	We propose that the lowered oxygen affinity of Tg-HbP in the presence of allosteric effectors is a consequence of an altered R-state conformation of Hb, which reflects the facilitation of switching the R-state of HbP to the T-state compared with the normal R-state of HbA, thereby reducing HbA"s affinity to oxygen.	Oxygen	28-34	heme binding protein 1	Homo sapiens	213-216
12962322-12	2003	We propose that the lowered oxygen affinity of Tg-HbP in the presence of allosteric effectors is a consequence of an altered R-state conformation of Hb, which reflects the facilitation of switching the R-state of HbP to the T-state compared with the normal R-state of HbA, thereby reducing HbA"s affinity to oxygen.	Oxygen	308-314	heme binding protein 1	Homo sapiens	50-53
12962322-12	2003	We propose that the lowered oxygen affinity of Tg-HbP in the presence of allosteric effectors is a consequence of an altered R-state conformation of Hb, which reflects the facilitation of switching the R-state of HbP to the T-state compared with the normal R-state of HbA, thereby reducing HbA"s affinity to oxygen.	Oxygen	308-314	heme binding protein 1	Homo sapiens	213-216
12655074-4	2003	From the present data the temperature variation of the oxygen grain boundary diffusivity, D(B) = 2.0 x 10(-5) exp (-0.91 eVk(B)T) m(2)s, and the oxygen surface exchange coefficient, k = 1.4 x 10(-2) exp (-1.13 eVk(B)T) ms, are derived.	Oxygen	55-61	muscleblind like splicing regulator 1	Homo sapiens	110-113
12595087-1	2003	Ultrasonically induced cell damage and active oxygen generation with 4-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-porphynyl(IX)-6-7-diaspartic acid (ATX-S10) were compared in the same in vitro insonation setup.	Oxygen	46-52	diencephalon/mesencephalon homeobox 1	Mus musculus	155-158
12595087-8	2003	These results suggest that ultrasonically generated active oxygen plays a primary role in the ultrasonically induced cell damage in the presence of ATX-S10.	Oxygen	59-65	diencephalon/mesencephalon homeobox 1	Mus musculus	148-151
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	Oxygen	72-78	prostaglandin D2 receptor	Homo sapiens	12-15
12628167-5	2003	Since intracellular Na(+) and Cl(-) both rise in oxygen-deprived cells, coactivation may more effectively trigger the activity of rSLO-2 channels in ischemia.	Oxygen	49-55	potassium sodium-activated channel subfamily T member 1	Rattus norvegicus	130-136
12631267-6	2003	Despite favorable energy scores, tyrosine in a position trans to PAH residue His290 or TH residue His336 interferes with the access of the essential cofactor dioxygen to the catalytic center, thereby blocking the enzymatic reaction.	Oxygen	158-166	phenylalanine hydroxylase	Homo sapiens	65-68
12603086-4	2003	The mean intracellular pH (pHi) in patients with COPD was similar to that of age-matched controls, but decreased in the patients with COPD by a mean pHi of 0.02 (p = 0.04), following supplemental oxygen.	Oxygen	196-202	glucose-6-phosphate isomerase	Homo sapiens	27-30
12603086-6	2003	The broadband component of the MR spectrum increased in all the patients with COPD (p = 0.01), suggesting altered phospholipid membrane fluidity in the brain associated with the change in pHi following oxygen administration.	Oxygen	202-208	glucose-6-phosphate isomerase	Homo sapiens	188-191
12543451-15	2003	During deacclimation there was a linear relationship between latency to CNS oxygen toxicity and the level of HSP72.	Oxygen	76-82	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	109-114
12388106-2	2003	During 8 days of culture under 5% O(2), but not room air, the addition of FGF2 to explants stimulated the formation of Gs-IB(4-)positive, CD31-positive, and Flk-1-positive microvessels in a concentration-dependent manner.	Oxygen	34-38	fibroblast growth factor 2	Mus musculus	74-78
12388106-6	2003	Our data suggest that low oxygen upregulates FGFR1 expression in embryonic aorta in vitro and renders it more responsive to FGF2.	Oxygen	26-32	fibroblast growth factor receptor 1	Mus musculus	45-50
12388106-6	2003	Our data suggest that low oxygen upregulates FGFR1 expression in embryonic aorta in vitro and renders it more responsive to FGF2.	Oxygen	26-32	fibroblast growth factor 2	Mus musculus	124-128
12371906-3	2003	Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta.	Oxygen	50-56	matrix metallopeptidase 2	Rattus norvegicus	66-71
12371906-3	2003	Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta.	Oxygen	50-56	matrix metallopeptidase 2	Rattus norvegicus	120-125
12537524-0	2003	Oxygen depletion during and after mTHPC-mediated photodynamic therapy in RIF1 and H-MESO1 tumors.	Oxygen	0-6	replication timing regulatory factor 1	Homo sapiens	73-77
12507560-1	2003	Recently, work on the mechanism of action of the von Hippel-Lindau tumour suppressor protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights into both cellular oxygen sensing and cancer pathogenesis.	Oxygen	193-199	von Hippel-Lindau tumor suppressor	Homo sapiens	94-98
12507560-2	2003	pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the degradation of hypoxia-inducible factor-1 (HIF) alpha-subunits, a process regulated by oxygen availability and blocked by disease causing pVHL mutations.	Oxygen	172-178	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
12507560-2	2003	pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the degradation of hypoxia-inducible factor-1 (HIF) alpha-subunits, a process regulated by oxygen availability and blocked by disease causing pVHL mutations.	Oxygen	172-178	von Hippel-Lindau tumor suppressor	Homo sapiens	223-227
12507560-3	2003	In normoxic cells, pVHL targeting of HIF-alpha subunits follows hydroxylation of critical HIF prolyl residues by a group of oxygen, 2-oxoglutarate- and iron-dependent enzymes.	Oxygen	124-130	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
12486057-9	2003	In contrast, profound effects of the absence of ArcA were seen under conditions of oxygen-restricted growth: increased respiration, an altered electron flux distribution over the cytochrome o- and d-terminal oxidases, and a significant change in the intracellular redox state were observed.	Oxygen	83-89	arginine deiminase	Escherichia coli	48-52
12444972-8	2002	MRG19 disruptant also showed a twofold increase in the rate of oxygen uptake as compared with the wild-type strain.	Oxygen	63-69	Csr2p	Saccharomyces cerevisiae S288C	0-5
12462570-4	2002	TSC increases whole-body oxygen consumption rates, and it is thought that its physiological effects are due to the increased oxygen availability.	Oxygen	25-31	solute carrier family 12 member 3	Rattus norvegicus	0-3
12462570-4	2002	TSC increases whole-body oxygen consumption rates, and it is thought that its physiological effects are due to the increased oxygen availability.	Oxygen	125-131	solute carrier family 12 member 3	Rattus norvegicus	0-3
12215428-6	2002	Cells lacking functional NF-kappaB p65 subunit were more sensitive to NO/O2 than their wild type counterparts.	Oxygen	73-75	RELA proto-oncogene, NF-kB subunit	Homo sapiens	25-38
2752138-10	1989	These results suggest that following an acute blood loss and during the recovery from a blood loss, the capacity to deliver oxygen, as represented by hematocrit, is the major regulator of EP production.	Oxygen	124-130	erythropoietin	Mus musculus	188-190
12215428-7	2002	This injury was partially rescued by transfection with a p65 expression construct, suggesting an inverse relationship between NF-kappaB and susceptibility to the cytotoxicity of NO/O2.	Oxygen	181-183	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-60
12215428-9	2002	However, exposure to NO/O2 caused a marked reduction in nuclear localization and an increase in protein carbonyl formation of NF-kappaB p65 subunit.	Oxygen	24-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-139
12409271-5	2002	Exposure to hyperoxia at each passage caused decrease (*, p&lt;0.05 vs. 21% O2) in ADRP mRNA expression in the d18 fibroblasts.	Oxygen	76-78	perilipin 2	Rattus norvegicus	83-87
2778808-6	1989	With the increase in oxygen tension from 40 to 150 mmHg, SOD and catalase activities increased significantly by day 35.	Oxygen	21-27	catalase	Ovis aries	65-73
2722790-1	1989	In the presence of phenylalanine and molecular oxygen, activated phenylalanine hydroxylase catalyzes the oxidation of tetrahydrobiopterin.	Oxygen	47-53	phenylalanine hydroxylase	Rattus norvegicus	65-90
2539373-0	1989	Presence of coupled trinuclear copper cluster in mammalian ceruloplasmin is essential for efficient electron transfer to oxygen.	Oxygen	121-127	ceruloplasmin	Homo sapiens	59-72
2561073-3	1989	Among the various scavengers of oxygen metabolites, catalase alone inhibited the killing of S. typhimurium LT2 and S. typhi 1079 by the xanthine-xanthine oxidase system, indicating that hydrogen peroxide contributed to the killing of Salmonellae.	Oxygen	32-38	Mn-containing catalase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	52-60
12599506-3	2002	The key feature of this synthesis is the construction of the heterocycle via an intramolecular attack of the terpenoid-derived C-8 oxygen function onto an oxidatively activated 1,2-dihydroxyphenyl unit.	Oxygen	131-137	homeobox C8	Homo sapiens	127-130
2744228-7	1989	The conservation of primary structure suggests a role of ESP1 peptide in oxygen consumption.	Oxygen	73-79	serine protease 21	Rattus norvegicus	57-61
12351678-1	2002	The product of the von Hippel-Lindau gene, pVHL, targets the alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF) for polyubiquitination in the presence of oxygen.	Oxygen	191-197	von Hippel-Lindau tumor suppressor	Homo sapiens	43-47
2719938-10	1989	The oxygen affinity of Hb4 in the presence of ZPP decreases with increasing mole ratio.	Oxygen	4-10	keratin 84	Homo sapiens	23-26
12364740-0	2002	ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells.	Oxygen	19-25	ataxia telangiectasia mutated	Mus musculus	0-3
2920044-4	1989	25 nmoles O2-/min/mg membrane protein) was obtained with comparable PK-M concentrations to that observed with the reconstituted PK-C system, and approximately 1/3 that obtained with arachidonic acid (AA) or SDS.	Oxygen	10-12	pyruvate kinase M1/2	Homo sapiens	68-72
2747068-6	1989	Breathing with oxygen was associated with a smooth increase in Pdi during the inspiratory phase which indicates efficient contraction of the diaphragm.	Oxygen	15-21	peptidyl arginine deiminase 1	Homo sapiens	63-66
12122018-4	2002	Ab initio quantum chemical calculations performed on such Michaelis complexes of the mammalian RNase A (EC ) and the microbial RNase T(1) (EC ) show negative charge build up on the 2"-oxygen upon substrate binding.	Oxygen	184-190	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
2610138-2	1989	In severe hypoxia nucleotide degradation via xanthine oxidase and urate oxidase requires about half of the oxygen consumed.	Oxygen	107-113	urate oxidase	Rattus norvegicus	66-79
12233803-5	2002	Does live harp playing produce statistically and clinically significant differences in physiological measures of heart rate, systolic and diastolic blood pressure, respiratory rate, and oxygen saturation?	Oxygen	186-192	ankyrin repeat and sterile alpha motif domain containing 4B	Homo sapiens	10-14
2790923-4	1989	(2) The production of EPO depends exponentially on the tissue oxygen pressure (e.g. in the renal production sites).	Oxygen	62-68	erythropoietin	Rattus norvegicus	22-25
2790925-5	1989	In detail this implies a quantitative description of the following processes: (1) changes in tissue oxygen tension (Pto2) due to increase in red cell numbers (red cell transfusion, posthypoxia), decrease in plasma volume (dehydration) or increase in atmospheric oxygen pressure (hyperoxia), (2) Pto2 dependent reduction of erythropoietin (EPO) production, (3) dose-response of reduced EPO-levels on erythropoietic amplification (omission of three to five mitoses).	Oxygen	100-106	erythropoietin	Rattus norvegicus	323-337
2790925-5	1989	In detail this implies a quantitative description of the following processes: (1) changes in tissue oxygen tension (Pto2) due to increase in red cell numbers (red cell transfusion, posthypoxia), decrease in plasma volume (dehydration) or increase in atmospheric oxygen pressure (hyperoxia), (2) Pto2 dependent reduction of erythropoietin (EPO) production, (3) dose-response of reduced EPO-levels on erythropoietic amplification (omission of three to five mitoses).	Oxygen	100-106	erythropoietin	Rattus norvegicus	339-342
2790925-5	1989	In detail this implies a quantitative description of the following processes: (1) changes in tissue oxygen tension (Pto2) due to increase in red cell numbers (red cell transfusion, posthypoxia), decrease in plasma volume (dehydration) or increase in atmospheric oxygen pressure (hyperoxia), (2) Pto2 dependent reduction of erythropoietin (EPO) production, (3) dose-response of reduced EPO-levels on erythropoietic amplification (omission of three to five mitoses).	Oxygen	100-106	erythropoietin	Rattus norvegicus	385-388
12233803-18	2002	Live harp playing also produced statistically significant differences in physiological measures of systolic blood pressure (P=.046), and oxygen saturation (P=.011).	Oxygen	137-143	ankyrin repeat and sterile alpha motif domain containing 4B	Homo sapiens	5-9
12213585-3	2002	We demonstrated that the regulation of glucagon receptor, insulin receptor and L-type pyruvate kinase (L-PK) gene expression in liver is dependent upon a cross-talk between oxygen and glucose.	Oxygen	173-179	insulin receptor	Rattus norvegicus	58-74
2744579-3	1989	Under aerobic conditions, the GSH-mediated reduction of ferry-myoglobin is associated with O2 consumption and amounts of GSSG are formed far in excess over that of the peroxide added.	Oxygen	91-93	myoglobin	Homo sapiens	62-71
12396011-3	2002	In addition, SP-D inhibits the generation of radical oxygen species or the propagation of lipid peroxidation.	Oxygen	53-59	pulmonary surfactant-associated protein D	Bos taurus	13-17
2917962-1	1989	At least two investigators have demonstrated a reduction in O2 extraction during induced hypothermia (Cain and Bradley, J. Appl.	Oxygen	60-62	nucleoporin 214	Homo sapiens	102-106
2632899-6	1989	These results suggest that the renal Epo-producing tissue or its oxygen-sensing system is less hypoxic in cyanated mice than in normal mice under 350 Torr, and that the physiologically optimal oxygen affinity of blood is variable depending on hypoxic degrees.	Oxygen	65-71	erythropoietin	Mus musculus	37-40
2548090-5	1989	The priming of macrophages with rIFN gamma had a significant effect in the additional increased production of H2O2, O2- and IL-1 when subsequently treated with cisplatin, LPS or MDP.	Oxygen	112-114	interferon gamma	Rattus norvegicus	32-42
2911604-1	1989	Peptidyl-glycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) catalyzes the conversion of a variety of glycine-extended peptides into biologically active alpha-amidated product peptides in a reaction dependent on copper, ascorbate, and molecular oxygen.	Oxygen	37-43	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	48-51
3267094-13	1988	The average value at 22 degrees C, 0.16 x 10(-6) cm2 s-1, is about 4 times smaller than values for myoglobin diffusivity at 20 degrees C commonly assumed in models of facilitated transport of oxygen by myoglobin.	Oxygen	192-198	myoglobin	Homo sapiens	99-108
3267094-13	1988	The average value at 22 degrees C, 0.16 x 10(-6) cm2 s-1, is about 4 times smaller than values for myoglobin diffusivity at 20 degrees C commonly assumed in models of facilitated transport of oxygen by myoglobin.	Oxygen	192-198	myoglobin	Homo sapiens	202-211
2855157-0	1988	[Scavenging of active oxygen by ceruloplasmin].	Oxygen	22-28	ceruloplasmin	Homo sapiens	32-45
2851658-0	1988	CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast.	Oxygen	25-31	Hap1p	Saccharomyces cerevisiae S288C	0-4
2851658-0	1988	CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast.	Oxygen	25-31	Hap1p	Saccharomyces cerevisiae S288C	6-10
2851659-0	1988	CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast.	Oxygen	25-31	Hap1p	Saccharomyces cerevisiae S288C	0-4
2851659-0	1988	CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast.	Oxygen	25-31	Hap1p	Saccharomyces cerevisiae S288C	6-10
2847729-0	1988	Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages.	Oxygen	77-83	PCNA clamp associated factor	Homo sapiens	0-26
2847729-1	1988	Platelet activating factor (PAF; C16), 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine) stimulated the production of active oxygen species by human monocyte-derived macrophages in culture.	Oxygen	130-136	PCNA clamp associated factor	Homo sapiens	0-26
2847729-1	1988	Platelet activating factor (PAF; C16), 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine) stimulated the production of active oxygen species by human monocyte-derived macrophages in culture.	Oxygen	130-136	PCNA clamp associated factor	Homo sapiens	28-31
2847729-6	1988	PAF was however distinguished by its potent capacity to stimulate O2- and H2O2 production even at late stages of macrophage maturation (18 days), at which time both PMA and zymosan lacked significant effect.	Oxygen	66-68	PCNA clamp associated factor	Homo sapiens	0-3
2467647-1	1988	The signal for erythropoietin (epo) production is partial oxygen tension.	Oxygen	58-64	erythropoietin	Mus musculus	15-29
2467647-1	1988	The signal for erythropoietin (epo) production is partial oxygen tension.	Oxygen	58-64	erythropoietin	Mus musculus	31-34
2467647-2	1988	Erythropoietin release from cultured macrophages, derived from unstimulated and unseparated mouse bone marrow cells, occurs in response to changing physiological oxygen concentrations.	Oxygen	162-168	erythropoietin	Mus musculus	0-14
2840749-7	1988	These data suggest that C5a activity may be related to oxygen products from xanthine oxidase.	Oxygen	55-61	complement C5	Rattus norvegicus	24-27
3382287-8	1988	In vitro studies revealed that human immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a in a dose-dependent manner, although human albumin treated identically as human immunoglobulin did not produce these complements.	Oxygen	75-81	complement C4A (Rodgers blood group)	Homo sapiens	100-103
3379047-5	1988	Deoxy OEP myoglobin at 25 degrees C reversibly binds oxygen with an affinity of P50 = 0.8 mm Hg, which is similar to that of native protein.	Oxygen	53-59	myoglobin	Homo sapiens	10-19
3287012-8	1988	After 8 hours of ex vivo preservation, hearts receiving superoxide dismutase and catalase had significantly better left and right ventricular performance, higher myocardial oxygen consumption, and lower lactate production than the control group.	Oxygen	173-179	catalase	Ovis aries	81-89
2841270-0	1988	Generation of intracellular active oxygens in mouse FM3A cells by 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole, the activated Trp-P-2.	Oxygen	35-42	polycystin 2, transient receptor potential cation channel	Mus musculus	128-135
2841270-5	1988	Since Trp-P-2(NHOH) in solution generates superoxide anion accompanying its oxidative degradation, we conclude that the Trp-P-2(NHOH) treatment produces intracellular active oxygens that can damage DNA.	Oxygen	174-181	polycystin 2, transient receptor potential cation channel	Mus musculus	6-13
2841270-5	1988	Since Trp-P-2(NHOH) in solution generates superoxide anion accompanying its oxidative degradation, we conclude that the Trp-P-2(NHOH) treatment produces intracellular active oxygens that can damage DNA.	Oxygen	174-181	polycystin 2, transient receptor potential cation channel	Mus musculus	120-127
2847661-9	1988	Significant release of .O2- was induced by M-GRAM, TNF, and GM-CSF, whereas H2O2 production was significantly stimulated only by M-GRAM and TNF, as shown by functional and ultrastructural assays.	Oxygen	24-26	colony stimulating factor 2	Homo sapiens	60-66
2832680-1	1987	SRI 62-834, an analog of the antitumor agent ET-18-OCH3 in which the oxygen atom at carbon atom 2 has been incorporated into a five-membered heterocycle, has been prepared and evaluated as an antitumor agent.	Oxygen	69-75	sorcin	Mus musculus	0-3
3675599-2	1987	The decrease of cytochrome P-450 by CBD required NADPH and molecular oxygen.	Oxygen	69-75	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	16-32
2957433-11	1987	Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice.	Oxygen	267-269	interferon gamma	Rattus norvegicus	36-46
2957433-11	1987	Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice.	Oxygen	267-269	interferon gamma	Rattus norvegicus	150-160
3497124-5	1987	Under nitrogen, the degradation of BSA was not altered by the addition of DNA, but in the presence of oxygen less BSA was lost for a given dose when DNA was present.	Oxygen	102-108	albumin	Bos taurus	114-117
3623070-3	1987	This enzyme is stimulated by the addition of CuSO4 and ascorbate and requires the presence of molecular oxygen and is thus similar to the peptidyl-glycine alpha-amidating monooxygenase (PAM) described in mammals.	Oxygen	104-110	peptidylglycine alpha-amidating monooxygenase L homeolog	Xenopus laevis	138-184
3623070-3	1987	This enzyme is stimulated by the addition of CuSO4 and ascorbate and requires the presence of molecular oxygen and is thus similar to the peptidyl-glycine alpha-amidating monooxygenase (PAM) described in mammals.	Oxygen	104-110	peptidylglycine alpha-amidating monooxygenase L homeolog	Xenopus laevis	186-189
2820102-5	1987	Serum angiotensin-converting enzyme (ACE) activity increased postdive in the He-O2 group only, and these increases were small.	Oxygen	80-82	angiotensin I converting enzyme	Canis lupus familiaris	6-35
2820102-5	1987	Serum angiotensin-converting enzyme (ACE) activity increased postdive in the He-O2 group only, and these increases were small.	Oxygen	80-82	angiotensin I converting enzyme	Canis lupus familiaris	37-40
3613686-2	1987	Lung glutathione S-transferase activity increases markedly in 5-day-old pups exposed to hyperoxia, as observed for the O2- scavenging enzyme, superoxide dismutase.	Oxygen	119-121	hematopoietic prostaglandin D synthase	Rattus norvegicus	5-30
2482677-0	1989	[Effects of low molecular weight hydroxyethyl starch (HES 40) in comparison with Ringer solution on oxygen tension in skeletal muscles of infected patients].	Oxygen	100-106	ribosome binding protein 1	Homo sapiens	54-57
2509242-1	1989	Pre-treatment of human neutrophils with rGM-CSF resulted in a 3-fold increase in the rate of fMet-Leu-Phe stimulated reactive oxidant generation, as assessed by luminol- and lucigenin-chemiluminescence and O2- secretion.	Oxygen	206-208	colony stimulating factor 2	Homo sapiens	44-47
2679067-4	1989	An endotoxemic sheep pulmonary dysfunction model demonstrated that: (1) ATIII prophylaxis prevents the typical decrease in arterial oxygen partial pressure; (2) ATIII prophylaxis combined with alpha-1-proteinase inhibitor significantly attenuates indices of pulmonary dysfunction.	Oxygen	132-138	antithrombin-III	Ovis aries	72-77
3620444-4	1987	A striking effect is observed in singly cyanomet valency hybrid hemoglobins; namely, (alpha +CN beta)A(alpha beta)CXL exhibits lower oxygen affinity and higher cooperativity than (alpha beta +CN)A(alpha beta)CXL.	Oxygen	133-139	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	93-100
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Oxygen	172-178	dopamine beta-hydroxylase	Rattus norvegicus	55-58
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Oxygen	172-178	dopamine beta-hydroxylase	Rattus norvegicus	168-171
12587735-4	2002	Reduced glutathione content and the activity of glutathione peroxidase and glutathione reductase increased with increase in oxygen concentration under nitrogen fixing conditions but decreased under anaerobic and nitrogenase repressed conditions.	Oxygen	124-130	glutathione-disulfide reductase	Homo sapiens	75-96
3552970-0	1987	Generation of an activated form of human C5 (C5b-like C5) by oxygen radicals.	Oxygen	61-67	complement C5	Homo sapiens	45-48
12413599-2	2002	In the present study contrast-enhanced magnetic resonance imaging (MRI) perfusion measurement was used to analyze the influence of hyperoxia (fraction of inspired oxygen (FiO2) = 1.0) on regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in awake, normoventilating volunteers (n = 19).	Oxygen	163-169	CCAAT/enhancer binding protein zeta	Rattus norvegicus	217-221
3816780-2	1987	The dynamics of two domains in the myoglobin molecule, close to the heme and inside the protein medium including the surface, are investigated through the study of the fluorescence oxygen quenching of two probes imbedded in the heme pocket: zinc protoporphyrin IX (with a fluorescence lifetime of 2.1 ns) and metal-free protoporphyrin IX (with a fluorescence lifetime of 17.8 ns).	Oxygen	181-187	myoglobin	Homo sapiens	35-44
12176040-0	2002	Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells.	Oxygen	11-17	angiopoietin 2	Homo sapiens	38-52
3078389-5	1987	As Gerschman so strikingly expressed it:--"The normal life span can be considered as a survival time for the organism exposed to 0.2 atmospheres of oxygen"--and that is air at sea level.	Oxygen	148-154	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	176-179
2673350-8	1989	The results presented here provide direct evidence that one or more of the three proteins that have cross-linked to the P33 are responsible for binding the manganese of the oxygen-evolving complex.	Oxygen	173-179	inhibitor of growth family member 1	Homo sapiens	120-123
2768086-0	1989	ABR threshold is a function of blood oxygen level.	Oxygen	37-43	ABR activator of RhoGEF and GTPase	Homo sapiens	0-3
12173922-1	2002	Cytochrome c oxidase catalyzes the one-electron oxidation of four molecules of cytochrome c and the four-electron reduction of dioxygen to water.	Oxygen	127-135	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
2768086-6	1989	ABR threshold was an inverse function of blood O2 level with an approximate 3.05 dB elevation for every mmHg decrease in PaO2 (2.89 dB/% SaO2).	Oxygen	47-49	ABR activator of RhoGEF and GTPase	Homo sapiens	0-3
2707381-4	1989	Only in the case of 0.5% O2 and 4 mM CCl4 were the monolayers damaged (18%) immediately after the 2-hr exposure; all other exposed cells were undamaged at that time point and the dose response of cell death as a function of CCl4 and oxygen concentration was not evident until the 6-hr time point.	Oxygen	25-27	C-C motif chemokine ligand 4	Homo sapiens	224-228
3783606-4	1986	These inhibitors incorporate structural features that resemble both tyramine and oxygen substrates, and as evidenced by steady-state kinetics, they appear to bind both the phenethylamine binding site and the active site copper atom(s) in DBH.	Oxygen	81-87	dopamine beta-hydroxylase	Homo sapiens	238-241
3783606-5	1986	A series of structural congeners that incorporate different bridging chain lengths between the phenyl ring (dopamine mimic) and the imidazole-2-thione group (oxygen mimic) define the optimum distance for inhibitory potency and the likely intersite distance in the DBH active site.	Oxygen	158-164	dopamine beta-hydroxylase	Homo sapiens	264-267
3790691-0	1986	Reduction of anoxia through myoglobin-facilitated diffusion of oxygen.	Oxygen	63-69	myoglobin	Homo sapiens	28-37
2707381-4	1989	Only in the case of 0.5% O2 and 4 mM CCl4 were the monolayers damaged (18%) immediately after the 2-hr exposure; all other exposed cells were undamaged at that time point and the dose response of cell death as a function of CCl4 and oxygen concentration was not evident until the 6-hr time point.	Oxygen	233-239	C-C motif chemokine ligand 4	Homo sapiens	37-41
12128191-1	2002	The Monod-Wyman-Changeux allosteric model parameters evaluated from accurate oxygen equilibrium curves (OECs) of hemoglobin that were measured in an extremely wide range of structural constraints, imposed by allosteric effectors, yielded a closed circle when log K(T) and log K(R) were plotted against log L(0) and log L(4), respectively, showing novel phenomena that L(0) and L(4) have a maximal value and a minimal value, respectively, and K(T) and K(R) vary by more than three orders of magnitude.	Oxygen	77-83	ribosomal protein L4	Homo sapiens	319-323
2909293-2	1989	The oxygen metabolites produced by hypoxanthine plus xanthine oxidase caused relaxation of the ductus that was inhibited by catalase (hydrogen peroxide scavenger) but not by superoxide dismutase (superoxide anion scavenger).	Oxygen	4-10	catalase	Ovis aries	124-132
2561361-3	1989	We have studied here the effects of oxygen-derived free radicals (ODFR) on latent human neutrophil collagenase.	Oxygen	36-42	matrix metallopeptidase 8	Homo sapiens	88-110
2632899-6	1989	These results suggest that the renal Epo-producing tissue or its oxygen-sensing system is less hypoxic in cyanated mice than in normal mice under 350 Torr, and that the physiologically optimal oxygen affinity of blood is variable depending on hypoxic degrees.	Oxygen	193-199	erythropoietin	Mus musculus	37-40
3790691-2	1986	In this paper a mathematical theory of facilitated diffusion is developed and used to determine the extent to which myoglobin increases the removal of oxygen from blood and aids in the reduction or elimination of regions of anoxia.	Oxygen	151-157	myoglobin	Homo sapiens	116-125
3017933-1	1986	The mechanism by which 2-bromo-4"-nitroacetophenone (BrNAP) inactivates cytochrome P-450c, which involves alkylation primarily at Cys-292, is shown in the present study to involve an uncoupling of NADPH utilization and oxygen consumption from product formation.	Oxygen	219-225	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	83-89
3017933-4	1986	Under aerobic conditions the rapid oxidation of NADPH catalyzed by alkylated cytochrome P-450c was associated with rapid reduction of molecular oxygen to hydrogen peroxide via superoxide anion.	Oxygen	144-150	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	77-94
3769053-7	1986	This indicated a specific requirement for the oxygen atom in elevating the quinone reductase activity, which was not the case for the elevation of microsomal epoxide hydrolase activity.	Oxygen	46-52	crystallin, zeta	Mus musculus	75-92
2497503-3	1989	Administration of the cyclooxygenase inhibitor indomethacin blocked the synthesis of prostanoids, so that 6kPGF1 alpha and TXB2 levels decreased to values below the detection level (10 pg.ml-1) both during normoxia or hypoxia, but did not affect pulmonary vascular resistance or the alveolar-arterial PO2 difference (PAi-Pa)O2.	Oxygen	302-304	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	22-36
18964710-0	1989	Evidence for the role of myoglobin in facilitating oxygen transport.	Oxygen	51-57	myoglobin	Homo sapiens	25-34
18964710-2	1989	Evidence for a role of myoglobin that has not been previously measured directly, namely, facilitation of oxygen transport, is presented.	Oxygen	105-111	myoglobin	Homo sapiens	23-32
18964710-3	1989	It is suggested that one molecule of oxygen can be contained within the structure of the oxidized form of myoglobin, but is not co-ordinated to the heme iron.	Oxygen	37-43	myoglobin	Homo sapiens	106-115
18964710-4	1989	Reduced myoglobin binds one molecule of oxygen to the heme iron but no reports have been found that suggest that the oxidized form of myoglobin binds to, or contains a molecule of, oxygen.	Oxygen	40-46	myoglobin	Homo sapiens	8-17
18964710-4	1989	Reduced myoglobin binds one molecule of oxygen to the heme iron but no reports have been found that suggest that the oxidized form of myoglobin binds to, or contains a molecule of, oxygen.	Oxygen	181-187	myoglobin	Homo sapiens	134-143
3791352-0	1986	Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac muscle.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
3791352-3	1986	Myoglobin was inactivated by adding 2 X 10(-3) mol X litre-1 sodium nitrite to the bath to abolish the facilitated diffusion of oxygen in the presence or absence of glycolytic blockade by 10(-4) mol X litre-1 sodium iodoacetate.	Oxygen	128-134	myoglobin	Homo sapiens	0-9
3791352-5	1986	Since the depression in mechanical function was reversible by increasing the bath oxygen tension to approximately equal to 600 mm Hg (79.8 kPa) it is concluded that the myoglobin facilitated diffusion of oxygen plays a role in maintaining the mechanical function of mammalian cardiac muscle under normal conditions.	Oxygen	82-88	myoglobin	Homo sapiens	169-178
3791352-5	1986	Since the depression in mechanical function was reversible by increasing the bath oxygen tension to approximately equal to 600 mm Hg (79.8 kPa) it is concluded that the myoglobin facilitated diffusion of oxygen plays a role in maintaining the mechanical function of mammalian cardiac muscle under normal conditions.	Oxygen	204-210	myoglobin	Homo sapiens	169-178
3957930-4	1986	Microsomes from 3-methylcholanthrene-treated rats and cytochrome P-450c in the reconstituted system form exclusively the diol expoxide-1 diastereomer, in which the benzylic hydroxyl group and oxirane oxygen are cis to each other, from the (+)-(3S,4S)-dihydrodiol.	Oxygen	200-206	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-71
12128191-1	2002	The Monod-Wyman-Changeux allosteric model parameters evaluated from accurate oxygen equilibrium curves (OECs) of hemoglobin that were measured in an extremely wide range of structural constraints, imposed by allosteric effectors, yielded a closed circle when log K(T) and log K(R) were plotted against log L(0) and log L(4), respectively, showing novel phenomena that L(0) and L(4) have a maximal value and a minimal value, respectively, and K(T) and K(R) vary by more than three orders of magnitude.	Oxygen	77-83	ribosomal protein L4	Homo sapiens	377-381
11971897-4	2002	Oxidation of thiol groups of cysteines by reactive oxygen, generated during UV irradiation, was the primary event in c-Raf activation, causing the release of zinc ions and, by inference, a change in CRD structure.	Oxygen	51-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	117-122
3719069-0	1986	A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber.	Oxygen	31-37	myoglobin	Homo sapiens	53-62
3719069-2	1986	The model describes the steady state, free and myoglobin-facilitated diffusion of oxygen into a respiring cylindrical muscle fiber cross section.	Oxygen	82-88	myoglobin	Homo sapiens	47-56
3719069-7	1986	The drop in oxygen tension from fiber periphery to core, however, does depend significantly on the myoglobin concentration, the oxygen tension level at the sarcolemma, and the oxygen and myoglobin diffusivities.	Oxygen	12-18	myoglobin	Homo sapiens	99-108
3053927-0	1988	Effects of in vivo administration of recombinant human granulocyte-macrophage colony-stimulating factor on human neutrophil chemotaxis and oxygen metabolism.	Oxygen	139-145	colony stimulating factor 2	Homo sapiens	55-103
12057761-6	2002	Here we briefly review the role of IRP in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest.	Oxygen	74-80	Wnt family member 2	Homo sapiens	35-38
3217227-1	1988	It is generally assumed that the O2 supply to the kidneys is the major determinant of the synthesis of erythropoietin (Ep).	Oxygen	33-35	erythropoietin	Rattus norvegicus	103-117
3217227-9	1988	From these results it may be concluded that decreasing oxygen supply to the kidney through reduction in renal blood flow (ischemic hypoxia) is less effective in increasing erythropoietin production than reducing the hemoglobin concentration (anemic hypoxia).	Oxygen	55-61	erythropoietin	Rattus norvegicus	172-186
2848333-8	1988	We have concluded in the case of rats and mice that the pulmonary IDO activity, even following induction, is too low for O2- to be the rate-limiting factor.	Oxygen	121-123	indoleamine 2,3-dioxygenase 1	Mus musculus	66-69
2848333-10	1988	However, in the rabbit, a species comparatively resistant to paraquat- and oxygen-induced lung damage, pulmonary IDO activity is 170 times that of rats or mice.	Oxygen	75-81	indoleamine 2,3-dioxygenase 1	Mus musculus	113-116
3957835-7	1986	The myocardial O2 consumption, estimated from the product HR X (Psas--Ppl), increased by 17 and 20% at Re and Ex, respectively.	Oxygen	15-17	HRX	Homo sapiens	58-62
3505230-1	1986	In the presence of peroxidase, myoglobin or hemoglobin, Tetrachlorodecaoxide (TCDO) forms an active oxygen species which is similar to the product of the polymorphonuclear leucocyte (PMNL) myeloperoxidase reaction and the "Klebanoff Model" of phagocytosis, but it is also produced under anaerobic conditions.	Oxygen	100-106	myoglobin	Homo sapiens	31-40
12004076-1	2002	The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability.	Oxygen	166-172	von Hippel-Lindau tumor suppressor	Homo sapiens	64-98
3108353-0	1986	Prevention of oxygen toxicity with superoxide dismutase and catalase in premature lambs.	Oxygen	14-20	catalase	Ovis aries	60-68
3210238-2	1988	The oxygen dissociation constants from Fe subunits in the half-ligated intermediate states of Fe-Co hybrid hemoglobins, alpha(Fe-O2)2 beta(Co)2 and alpha(Co)2 beta(Fe-O2)2, have been determined as functions of pH, temperature and inositol hexaphosphate.	Oxygen	4-10	complement C2	Homo sapiens	120-143
3108353-2	1986	This study explores if exogenous polyethylene glycol conjugated superoxide dismutase (PEG-SOD) and catalase (PEG-CAT) mitigate oxygen toxicity in premature lambs with respiratory distress syndrome.	Oxygen	127-133	catalase	Ovis aries	86-107
12004076-1	2002	The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability.	Oxygen	166-172	von Hippel-Lindau tumor suppressor	Homo sapiens	100-104
12004076-2	2002	pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent.	Oxygen	95-101	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
12107433-2	2002	The major objective of this communication is to construct a phenotypic signature for cells of the nucleus pulposus that is based on the hypothesis that in response to restriction on oxygen and nutrient flux, there is expression of HIF-1, GLUT-1 and MMP-2.	Oxygen	182-188	solute carrier family 2 member 1	Rattus norvegicus	238-244
4084587-5	1985	These spectral changes are not present in the geminate recombination of photolyzed complexes of myoglobin with the diatomic ligands oxygen and carbon monoxide.	Oxygen	132-138	myoglobin	Homo sapiens	96-105
3001693-5	1985	Each of the covalently recombined analogous cytochromes c could retain an electron in the presence of oxygen and transfer it to cytochrome c oxidase, although with different reaction rates and Michaelis constants.	Oxygen	102-108	cytochrome c, somatic	Equus caballus	128-140
2853633-2	1988	The ability of serum proteins (albumin, immunoglobulin G) and protein antioxidants (ceruloplasmin, superoxide dismutase and transferrin) to react with O2-.	Oxygen	151-153	ceruloplasmin	Homo sapiens	84-97
2853633-5	1988	Ceruloplasmin is the most effective OCl- trapping protein, and it reacts with O2-.	Oxygen	78-80	ceruloplasmin	Homo sapiens	0-13
2853633-7	1988	Therefore, ceruloplasmin is supposed to be the main scavenger of toxic oxygen species generated by stimulated neutrophils.	Oxygen	71-77	ceruloplasmin	Homo sapiens	11-24
3197437-3	1988	The oxygen permeability of the 1-liter EV bag averaged 1447 nmol/min/atm, which was about 1.5 times higher than that of PVC bags.	Oxygen	4-10	ATM serine/threonine kinase	Homo sapiens	69-72
2466914-3	1988	An increase in O2 consumption after f-MLP-stimulation was seen when PMN had been incubated 2-4 h with either 1000 IU/ml IFN-alpha or 100 IU/ml IFN-gamma, but this increase in O2 consumption was not observed with 1000 IU/ml IFN-beta.	Oxygen	15-17	MARCKS like 1	Homo sapiens	38-41
12107433-2	2002	The major objective of this communication is to construct a phenotypic signature for cells of the nucleus pulposus that is based on the hypothesis that in response to restriction on oxygen and nutrient flux, there is expression of HIF-1, GLUT-1 and MMP-2.	Oxygen	182-188	matrix metallopeptidase 2	Rattus norvegicus	249-254
3197995-0	1988	Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis.	Oxygen	8-14	PCNA clamp associated factor	Homo sapiens	40-66
2417371-0	1985	A new technique for measuring oxygen saturations of hemoglobin and myoglobin and its application in open heart surgery.	Oxygen	30-36	myoglobin	Homo sapiens	67-76
12045263-8	2002	Breathing 10% oxygen for 3 weeks produced less right ventricular hypertrophy in cPLA(2alpha)(-/-) than in cPLA(2alpha)(+/+) mice, but restored HPV in cPLA(2alpha)(-/-) mice despite the continued absence of cPLA(2) activity.	Oxygen	14-20	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	80-91
2417371-1	1985	Light reflected from the human heart surface was used to determine mixed hemoglobin and myoglobin oxygen saturations (O2SAT) in the cardiac tissue.	Oxygen	98-104	myoglobin	Homo sapiens	88-97
2459100-1	1988	The hyperoxia-induced increases in the activity of lung glucose-6-phosphate dehydrogenase (G-6-P) and glutathione reductase (GR) after exposure of rats to greater than 97% O2 for 6 days were accompanied by equivalent increases in the amount of the respective immunoreactive proteins.	Oxygen	172-174	glutathione-disulfide reductase	Rattus norvegicus	102-123
2459100-1	1988	The hyperoxia-induced increases in the activity of lung glucose-6-phosphate dehydrogenase (G-6-P) and glutathione reductase (GR) after exposure of rats to greater than 97% O2 for 6 days were accompanied by equivalent increases in the amount of the respective immunoreactive proteins.	Oxygen	172-174	glutathione-disulfide reductase	Rattus norvegicus	125-127
2459100-3	1988	Fetal rat lung explants cultured 4 days in 95% O2 showed increased G-6-P and GR activity and increased levels of the specific proteins 1.5-fold those of explants at 2 days of culture.	Oxygen	47-49	glutathione-disulfide reductase	Rattus norvegicus	77-79
12045263-8	2002	Breathing 10% oxygen for 3 weeks produced less right ventricular hypertrophy in cPLA(2alpha)(-/-) than in cPLA(2alpha)(+/+) mice, but restored HPV in cPLA(2alpha)(-/-) mice despite the continued absence of cPLA(2) activity.	Oxygen	14-20	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	106-117
2867775-3	1985	The FAB technique is also able to quantitatively determine the oxygen-18 or oxygen-17 content of nucleotides on as little as 10 nmol of material with no prior derivatization.	Oxygen	63-69	FA complementation group B	Homo sapiens	4-7
12045263-8	2002	Breathing 10% oxygen for 3 weeks produced less right ventricular hypertrophy in cPLA(2alpha)(-/-) than in cPLA(2alpha)(+/+) mice, but restored HPV in cPLA(2alpha)(-/-) mice despite the continued absence of cPLA(2) activity.	Oxygen	14-20	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	106-117
2867775-4	1985	Acetyl-CoA synthetase has been shown by FAB-MS to catalyze the positional exchange of an oxygen-18 of ATP from the beta-nonbridge position to the alpha beta-bridge position in the presence of acetate.	Oxygen	89-95	FA complementation group B	Homo sapiens	40-43
3397622-2	1988	The current study ascribes another oxygen-responsive role to adenosine, that of regulating synthesis of the erythropoiesis-stimulating hormone, erythropoietin.	Oxygen	35-41	erythropoietin	Rattus norvegicus	144-158
3397622-6	1988	The results suggest that adenosine may function as a mediator to link oxygen supply with erythropoietin production.	Oxygen	70-76	erythropoietin	Rattus norvegicus	89-103
12045263-8	2002	Breathing 10% oxygen for 3 weeks produced less right ventricular hypertrophy in cPLA(2alpha)(-/-) than in cPLA(2alpha)(+/+) mice, but restored HPV in cPLA(2alpha)(-/-) mice despite the continued absence of cPLA(2) activity.	Oxygen	14-20	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	80-86
11940656-3	2002	Hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of HIF-1 alpha regulates its interaction with the von Hippel-Lindau protein (VHL) that targets HIF-1 alpha for ubiquitination and proteasomal degradation.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	139-164
2836196-5	1988	The sum of the q+/2e stoichiometries of cytochrome oxidase and the cytochrome bc1 complex determined separately was similar to their value determined together for electron transport from succinate to oxygen over the range of membrane potentials studied.	Oxygen	200-206	brain cytoplasmic RNA 1	Rattus norvegicus	78-81
2996519-1	1985	Reoxidation process of reduced cucumber ascorbate oxidase (1.10.3.3) with dioxygen was investigated in detail through absorption, circular dichroic (CD) and electron paramagnetic resonance (EPR) spectra.	Oxygen	74-82	L-ascorbate oxidase	Cucumis sativus	40-57
11940656-3	2002	Hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of HIF-1 alpha regulates its interaction with the von Hippel-Lindau protein (VHL) that targets HIF-1 alpha for ubiquitination and proteasomal degradation.	Oxygen	53-59	von Hippel-Lindau tumor suppressor	Homo sapiens	166-169
11916399-4	2002	A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation.	Oxygen	183-191	complement C6	Homo sapiens	55-58
4059037-6	1985	Oxygen saturated CSF superfusion of the ischemic brain cortex restored the cortical NAD/NADH redox state to the preanoxic level (oxidation of NADH).	Oxygen	0-6	colony stimulating factor 2	Homo sapiens	17-20
4059037-7	1985	10(-1) M cyanide, applied after superfusion of the brain cortex with oxygen saturated CSF resulted in comparable NAD reduction to that produced by "non flow anoxia".	Oxygen	69-75	colony stimulating factor 2	Homo sapiens	86-89
4016080-0	1985	Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species.	Oxygen	64-70	phenylalanine hydroxylase	Rattus norvegicus	0-25
2976230-7	1988	The function of the increased MYO content may be to facilitate the oxygen extraction.	Oxygen	67-73	myoglobin	Homo sapiens	30-33
3277502-5	1988	Intraperitoneal injections of catalase (50 mg/kg) prior to infusing endotoxin in these same sheep resulted in substantial catalase activity in plasma and in lung lymph, and attenuated the expected changes in pulmonary arterial pressure, lung lymph flow, and arterial leukocyte counts and oxygen tension after endotoxin infusions.	Oxygen	288-294	catalase	Ovis aries	30-38
12207052-5	2002	If neonatal mice were exposed to &gt;95% oxygen, lung development was impaired and midkine expression was suppressed.	Oxygen	41-47	midkine	Mus musculus	83-90
2896638-4	1988	Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond.	Oxygen	220-226	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	163-166
3926281-5	1985	For embryonic chick calvaria whose viability was assured by the measurement of oxygen consumption, parathyroid hormone at dosage levels up to pharmacological caused an increase in the measured potential difference and thus in the inferred activity level of ionic transport through the membrane.	Oxygen	79-85	parathyroid hormone	Gallus gallus	99-118
11978059-7	2002	Using villous explants, we have demonstrated that the oxygen-regulated events of early trophoblast differentiation are in part mediated by TGFbeta(3), an inhibitor of trophoblast differentiation, via HIF-1alpha.	Oxygen	54-60	transforming growth factor beta 3	Homo sapiens	139-146
2826469-0	1988	Protein I, a translocatable ion channel from Neisseria gonorrhoeae, selectively inhibits exocytosis from human neutrophils without inhibiting O2- generation.	Oxygen	142-144	annexin A2	Homo sapiens	0-9
3978235-4	1985	This early fall in the erythropoietin level was associated with a sustained decrease in blood oxygen affinity (increase in P50).	Oxygen	94-100	erythropoietin	Rattus norvegicus	23-37
11790723-0	2002	Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3.	Oxygen	20-26	transforming growth factor beta 3	Homo sapiens	65-128
3189015-14	1988	Cranial CSF volume increased in 11 subjects during O2 inhalation (range -0.5 to +26.7 ml mean 10.9 ml).	Oxygen	51-53	colony stimulating factor 2	Homo sapiens	8-11
2984169-4	1985	At sea level, alveolar-arterial PO2 differences were approximately 10 Torr at rest, increasing to approximately 20 Torr at a metabolic consumption of O2 (VO2) of 3 l/min.	Oxygen	33-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	3-6
11818396-4	2002	A window of susceptibility to oxygen-induced vaso-obliteration was defined by comparing the extent of retinal vaso-obliteration resulting from 2 days of hyperoxia beginning on P7, P9, P11, P13, or P15.	Oxygen	30-36	S100 calcium binding protein A10 (calpactin)	Mus musculus	184-187
11929192-7	2002	While UCP1 has a clear role in energy homeostasis, the newcomers UCP2-UCP5 may have more delicate physiological importance acting as free radical oxygen scavengers and in the regulation of ATP-dependent processes, such as secretion.	Oxygen	146-152	uncoupling protein 2	Homo sapiens	65-69
2983185-5	1985	Calculated electron and spin densities indicate that the radical formed by H abstraction from the phenol oxygen does not remain localized on the oxygen, but is primarily a semiquinone aryl radical with significant unpaired spin density on the ring carbon atoms, particularly on C-3 and C-5.	Oxygen	105-111	complement C5	Homo sapiens	286-289
3335171-7	1988	Inspired partial pressure of oxygen falls from 159 mm Hg at sea level to 127 mm Hg at 6,200 feet and further declines to 113 mm Hg at 9,000 ft.	Oxygen	29-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
11907823-2	2002	The aim of the present study was to examine the hypothesis that up-regulation of both ETA receptor and endogenous ET-1 expression in CB chemoreceptors enhances the response of intracellular Ca2+ to ET-1 following adaptation to chronic hypoxia (10% inspired O2 for 3-4 weeks).	Oxygen	257-259	endothelin receptor type A	Rattus norvegicus	86-89
2855735-4	1988	Furthermore, we found that GM-CSF, but not G-CSF, increased O2- production at some concentrations of the stimulus.	Oxygen	60-62	colony stimulating factor 2	Homo sapiens	27-33
2855735-5	1988	Preincubation of neutrophils with cycloheximide in the absence of CSF caused a marked fall in O2- -production that was first evident at 2 hours.	Oxygen	94-96	colony stimulating factor 2	Homo sapiens	66-69
2987071-8	1985	Finally, the expression of superoxide dismutase and peroxidase isozymes appears to be coordinated during differentiation in a manner that is consistent with their role in an integrated mechanism for the removal of reduced oxygen species.	Oxygen	222-228	peroxidase N1	Nicotiana tabacum	52-62
11805327-3	2002	We have demonstrated a dramatic increase in the angiogenic response to oxygen-induced retinal ischemia in transgenic mice overexpressing PKC beta 2 isoform and a significant decrease in retinal neovascularization in PKC beta isoform null mice.	Oxygen	71-77	protein kinase C, beta	Mus musculus	137-145
6511797-5	1984	The rate of decay of the dioxygen complex was increased in all cases with b5 present; however, with oxidized b5 a large increase in the rate was observed with P-450 isozyme 4 but not with isozyme 2, whereas the opposite situation was found when reduced b5 was used.	Oxygen	25-33	cytochrome P450 1A2	Oryctolagus cuniculus	159-174
3436869-8	1987	Alveolar-end-capillary diffusion limitation of O2 uptake (VO2) was observed at VO2 greater than 3 l/min at sea level, greater than 1-2 l/min VO2 at PB = 428 and 347 Torr, and at higher altitudes, at VO2 less than or equal to 1 l/min.	Oxygen	47-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	107-110
12017335-1	2002	Earlier studies have shown that the retinoblastoma protein (pRb) is involved in cell-cycle regulation under conditions of moderate hypoxia, which is the term we use to denote oxygen concentrations just above the lower level giving full respiration, ie.	Oxygen	175-181	RB transcriptional corepressor 1	Homo sapiens	60-63
6090441-11	1984	These data suggest that the increase in microsomal cytochrome P-450 activities represents an increase in enzyme synthesis and, furthermore, that reduction of oxygen tension decreases degradation of newly synthesized Leydig cell microsomal cytochrome P-450 activities as recently reported (Quinn, P.G., and Payne, A.H. (1984) J. Biol.	Oxygen	158-164	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	239-255
6497839-1	1984	Treatment of cobalt-substituted haemoglobin and myoglobin with ascorbate and molecular O2 (coupled oxidation) resulted in biliverdin formation from the cobalt(II) derivatives but not from the cobalt(III) derivatives.	Oxygen	87-89	myoglobin	Homo sapiens	48-57
12640179-1	2002	We tested the response of stress-activated mitogen-activated protein kinases (MAPKs) - p38 MAPK and c-JUN NH2-terminal kinase (JNK) - following hypoxia-ischemia (H-I) induced by unilateral carotid artery ligation and hypoxia (8% O2 and 92% N2) for 2.5 h in postnatal-day-7 rats.	Oxygen	229-231	mitogen activated protein kinase 14	Rattus norvegicus	87-90
6095974-5	1984	Moreover, recent work from my laboratory indicates that in vitro at alkaline pH in the presence of Mg2+, the biologically active diphenols (beta-3,4-dihydroxyphenylalanine and the beta-adrenergic agonists isoproterenol, norepinephrine, and epinephrine) appear to function as electron donor substrates for human erythrocyte catalase and inhibit the production of O2 from H2O2 at micromolar concentrations.	Oxygen	362-364	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	140-148
6088632-0	1984	Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G.	Oxygen	20-26	cathepsin G	Homo sapiens	139-150
6465677-0	1984	Serum fibronectin is elevated during normobaric and hyperbaric oxygen exposure in rats.	Oxygen	63-69	fibronectin 1	Rattus norvegicus	6-17
6465677-1	1984	Serum fibronectin concentration was measured by immunoelectrophoresis in rats exposed to 1 atmosphere absolute (ata) of oxygen for 24 to 72 h and at 30-min intervals during 1 to 5 h of exposure to 4 ata O2.	Oxygen	120-126	fibronectin 1	Rattus norvegicus	6-17
6465677-5	1984	This study demonstrated a progressive increase in serum fibronectin in the oxygen-exposed rat.	Oxygen	75-81	fibronectin 1	Rattus norvegicus	56-67
11936849-6	2002	In addition to binding the GPx-ORE, the OREBP was itself regulated by oxygen tension.	Oxygen	70-76	nuclear factor of activated T cells 5	Homo sapiens	40-45
6744365-9	1984	The capacity for oxygen diffusion in relation to oxygen demand measured as the ratio of myoglobin to fibre diameter appeared to be of similar magnitude in skeletal muscle and left ventricle but was higher in papillary muscle.	Oxygen	17-23	myoglobin	Homo sapiens	88-97
6744365-9	1984	The capacity for oxygen diffusion in relation to oxygen demand measured as the ratio of myoglobin to fibre diameter appeared to be of similar magnitude in skeletal muscle and left ventricle but was higher in papillary muscle.	Oxygen	49-55	myoglobin	Homo sapiens	88-97
6090312-7	1984	Other enzymes, the lipoxygenases, may instead introduce oxygen at C-5, C-8, C-9, C-12 or C-15: further conversions from, for example, the initially formed 5- or 15-hydroperoxy acids may lead to the leukotrienes.	Oxygen	22-28	complement C5	Homo sapiens	66-69
11742085-0	2001	BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia.	Oxygen	39-45	BH3 interacting domain death agonist	Mus musculus	0-3
6322283-3	1984	Fusion of the azurophil and specific granules with the phagocytic vacuole results in secretion of BPI, the primary oxygen independent bactericidal protein, and of myeloperoxidase into the phagolysosome.	Oxygen	115-121	bactericidal permeability increasing protein	Homo sapiens	98-101
11742085-4	2001	After 2 h of oxygen/glucose deprivation, BID cleavage was detected in neurons concurrent with caspase 8 activation but before caspase 3 cleavage.	Oxygen	13-19	BH3 interacting domain death agonist	Mus musculus	41-44
11742085-5	2001	Bid(-/-) neurons were resistant to death after oxygen/glucose deprivation, and caspase 3 cleavage was significantly reduced; however, caspase 8 cleavage did not differ from wild type.	Oxygen	47-53	BH3 interacting domain death agonist	Mus musculus	0-3
6093833-4	1984	The activity of phosphatidic acid phosphatase (PAPase) showed a statistically significant decrease in the oxygen-poisoned lung.	Oxygen	106-112	ubiquitin-conjugating enzyme E2D 3	Rattus norvegicus	47-53
11684051-1	2001	The predictive value of increase in cerebral blood flow (CBF) was examined to detect hyperbaric oxygen (HBO(2))-induced electrical discharge in artificially ventilated rats at three PaCO(2) levels under 5 atmospheric pressures.	Oxygen	96-102	CCAAT/enhancer binding protein zeta	Rattus norvegicus	57-60
6703477-9	1984	We conclude that marked changes in lung ODC activity and polyamine content occur during the repair of oxygen-induced injury to the lung and that selective inhibition of these changes adversely affects repair.	Oxygen	102-108	ornithine decarboxylase 1	Rattus norvegicus	40-43
11691886-14	2001	Oxygen extraction was higher during the first 60 s of EX2 and EX3 than in EX 1 and thigh oxygen uptake was elevated (P &lt; 0.05) during the first 120 s of EX2 and throughout EX3 compared to EX1.	Oxygen	0-6	FERM domain containing 6	Homo sapiens	191-194
6731954-6	1984	In addition, the importance of oxygen-independent bactericidal mechanisms has been confirmed by the discovery of proteins such as BPI (Bactericidal Permeability Increasing Protein).	Oxygen	31-37	bactericidal permeability increasing protein	Homo sapiens	130-133
6731954-6	1984	In addition, the importance of oxygen-independent bactericidal mechanisms has been confirmed by the discovery of proteins such as BPI (Bactericidal Permeability Increasing Protein).	Oxygen	31-37	bactericidal permeability increasing protein	Homo sapiens	135-179
6417272-0	1983	Dopamine-beta-hydroxylase activity of the cat carotid body under different arterial O2 and CO2 conditions.	Oxygen	84-86	dopamine beta-hydroxylase	Homo sapiens	0-25
6667476-4	1983	When the amino and carboxyl groups of the amino acid are blocked, noticeable interaction of Gd3+ with the glycosidic oxygen atom (O-3) and O-2" for the glycopeptide containing alpha-D-Galp, and with O-3 and N-2" for the glycopeptide containing alpha-D-GalpNAc, is observed.	Oxygen	117-123	GRDX	Homo sapiens	92-95
6653501-4	1983	After 7 days in 85% oxygen (0 days in air) activities of G6PD, GR, and GP, were elevated above control values by 189%, 32%, and 126%, respectively, and NPSH was 146% higher.	Oxygen	20-26	glutathione-disulfide reductase	Rattus norvegicus	63-65
6311895-4	1983	Analysis of the modulation by MAF and IFN-beta of M phi diameter ability to release the oxygen metabolites O2- and H2O2, molecules possibly involved in the effector mechanism of both M phi diameter cytotoxicity and suppression, revealed a close correlation with the patterns of suppressive activity in both nondefective and defective strains.	Oxygen	88-94	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	30-33
6311895-4	1983	Analysis of the modulation by MAF and IFN-beta of M phi diameter ability to release the oxygen metabolites O2- and H2O2, molecules possibly involved in the effector mechanism of both M phi diameter cytotoxicity and suppression, revealed a close correlation with the patterns of suppressive activity in both nondefective and defective strains.	Oxygen	107-109	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	30-33
6354267-1	1983	At an intermediate stage in the hydrolysis of magnesium adenosine 5"-phosphate (MgATP) by myosin or actomyosin, there is an exchange of oxygen between water and the P gamma group of enzyme-bound nucleotide.	Oxygen	136-142	myosin heavy chain 14	Homo sapiens	90-96
6354267-7	1983	These normal pathways differ in the mode of interaction between actin and myosin in the course of hydrolysis; one is the Lymn-Taylor pathway where oxygen exchange occurs at a stage when actin and myosin are dissociated; the other is a pathway in which actin and myosin are associated during oxygen exchange.	Oxygen	147-153	myosin heavy chain 14	Homo sapiens	196-202
6354267-7	1983	These normal pathways differ in the mode of interaction between actin and myosin in the course of hydrolysis; one is the Lymn-Taylor pathway where oxygen exchange occurs at a stage when actin and myosin are dissociated; the other is a pathway in which actin and myosin are associated during oxygen exchange.	Oxygen	147-153	myosin heavy chain 14	Homo sapiens	196-202
6354267-7	1983	These normal pathways differ in the mode of interaction between actin and myosin in the course of hydrolysis; one is the Lymn-Taylor pathway where oxygen exchange occurs at a stage when actin and myosin are dissociated; the other is a pathway in which actin and myosin are associated during oxygen exchange.	Oxygen	291-297	myosin heavy chain 14	Homo sapiens	74-80
6354267-7	1983	These normal pathways differ in the mode of interaction between actin and myosin in the course of hydrolysis; one is the Lymn-Taylor pathway where oxygen exchange occurs at a stage when actin and myosin are dissociated; the other is a pathway in which actin and myosin are associated during oxygen exchange.	Oxygen	291-297	myosin heavy chain 14	Homo sapiens	196-202
6354267-7	1983	These normal pathways differ in the mode of interaction between actin and myosin in the course of hydrolysis; one is the Lymn-Taylor pathway where oxygen exchange occurs at a stage when actin and myosin are dissociated; the other is a pathway in which actin and myosin are associated during oxygen exchange.	Oxygen	291-297	myosin heavy chain 14	Homo sapiens	196-202
6354267-10	1983	The findings suggest, e.g., that during contraction, myosin can dissociate from the actin filament only during every other cycle of MgATP hydrolysis or that only half the heads, at any one time, can exchange oxygen while free of the actin filament.	Oxygen	208-214	myosin heavy chain 14	Homo sapiens	53-59
6354259-4	1983	This indicates an asymmetric transition state in which the new bond is hardly, if at all, formed, while the bond between C-5 and oxygen is substantially broken.	Oxygen	129-135	complement C5	Homo sapiens	121-124
6616056-1	1983	Photosensitized luminescence of singlet (1 delta g) molecular oxygen with the maximum at 1272 nm has been found in solutions of psoralen, angelicin and 8-methoxypsoralen in CCl4.	Oxygen	62-68	C-C motif chemokine ligand 4	Homo sapiens	173-177
6870872-1	1983	Ornithine decarboxylase activity increases 2-fold above control after 1 day and 25-fold after 3 days of exposure to 0.85 atm oxygen.	Oxygen	125-131	ornithine decarboxylase 1	Rattus norvegicus	0-23
6854651-6	1983	Comparison of the two results using the simplest kinetic model suggests that the 30-fold more rapid overall association rate for the reaction of oxygen with myoglobin compared to carbon monoxide results mainly from faster binding at the heme, with a small contribution from more rapid entry of oxygen into the protein from the solvent.	Oxygen	145-151	myoglobin	Homo sapiens	157-166
6854651-6	1983	Comparison of the two results using the simplest kinetic model suggests that the 30-fold more rapid overall association rate for the reaction of oxygen with myoglobin compared to carbon monoxide results mainly from faster binding at the heme, with a small contribution from more rapid entry of oxygen into the protein from the solvent.	Oxygen	294-300	myoglobin	Homo sapiens	157-166
24264606-2	1983	The Tiron radical signal obtained from chloroplasts is sensitive to superoxide dismutase (EC 1.15.1.1) confirming that it is derived from[Formula: see text], oxygen-dependent and unaffected by 3-(3,4-dichlorophenyl)-1,1-dimethyl urea and hydroxylamine.	Oxygen	158-164	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	90-94
17735192-4	1983	Sea level data from raised reefs indicate that the interglacial marine oxygen isotope oscillations during oxygen isotope stage 5 are a result of 30 percent ice volume effects and 70 percent temperature effects.	Oxygen	71-77	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
17735192-4	1983	Sea level data from raised reefs indicate that the interglacial marine oxygen isotope oscillations during oxygen isotope stage 5 are a result of 30 percent ice volume effects and 70 percent temperature effects.	Oxygen	106-112	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
6296862-0	1983	Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast.	Oxygen	28-34	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	49-53
6296862-2	1983	CYC1 mRNA and tr-1 accumulation occurred only in the presence of oxygen while tr-2 appeared only under anaerobic conditions.	Oxygen	65-71	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	0-4
6296862-8	1983	The inversion mutation produced a reversed pattern of CYC1 regulation in which the mRNA was present in anaerobically grown cells but absent in the presence of oxygen, mimicking wild-type tr-2 regulation and suggesting that the CYC1 transcription unit is under the control of the translocated tr-2 modulator sequences.	Oxygen	159-165	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	54-58
6648984-2	1983	T-2 toxin (2.2 mM) inhibited oxygen consumption by 40% in ADP-coupled and DNP-uncoupled mitochondria using either succinate or pyridine-nucleotide linked substrates.	Oxygen	29-35	brachyury 2	Rattus norvegicus	0-3
3663437-3	1987	P95 is the tension at which the haemoglobin would be 95% saturated and can, therefore, constitute a target tension for near-maximum arterial content of oxygen.	Oxygen	152-158	nibrin	Homo sapiens	0-3
3696161-2	1987	The transcription rates of lactate dehydrogenase, pyruvate kinase, triosephosphate isomerase and aldolase increased by 2-5 fold during the 72 hr exposure to 2% oxygen.	Oxygen	160-166	triosephosphate isomerase	Rattus norvegicus	67-92
3619163-2	1987	Myoglobin, an oxygen-carrying protein found in cardiac muscle and striated skeletal muscle, presents an attractive alternative to CPK and LDH in the emergency department setting for identification of acute myocardial infarction.	Oxygen	14-20	myoglobin	Homo sapiens	0-9
3663461-3	1987	CCNU toxicity was enhanced in all cell subpopulations of both tumours and spheroids, with greater consistency than might be predicted on the basis of the known variations in oxygen tension.	Oxygen	174-180	cyclin O	Homo sapiens	0-4
3311417-4	1987	For instance, CCl4-induced lipid peroxidation exhibits a distinct maximum at PO2 of around 7 mmHg, and iron-induced lipid peroxidation shows marked differences in its O2 dependence between an early lag phase and a later phase of self-accelerating propagation.	Oxygen	78-80	C-C motif chemokine ligand 4	Homo sapiens	14-18
3600760-1	1987	The refined 1.9-A resolution structure of the periplasmic D-galactose-binding protein (GBP) reveals a calcium ion surrounded by seven ligands, all protein oxygen atoms.	Oxygen	155-161	transmembrane protein 132A	Homo sapiens	58-85
3600760-1	1987	The refined 1.9-A resolution structure of the periplasmic D-galactose-binding protein (GBP) reveals a calcium ion surrounded by seven ligands, all protein oxygen atoms.	Oxygen	155-161	transmembrane protein 132A	Homo sapiens	87-90
3606920-6	1987	Up to 11 days exposure of rats to 80% oxygen was not lethal, but resulted in overt cellular damage to red blood cells (haemoglobin concentration decreased from 13.8 +/- 1.4 (SD) g dl-1 to 12.4 +/- 0.5 g dl-1; hydrogen peroxide-induced haemolysis increased from 7.7 +/- 1.6% to 75.1 +/- 13.5% after 11 days of hyperoxia) and to cells of lung (4-fold increase in lipid peroxidation) as well as a biochemical adaptation to the increased concentration of oxygen metabolites (superoxide dismutase increased 3-fold, catalase 5-fold and glutathione peroxidase 2-fold).	Oxygen	38-44	glutathione peroxidase 2	Rattus norvegicus	530-554
3037351-6	1987	The weak oxygen regulation in wild-type cells and the enhanced induction in CYP1-16 mutants were found to be mediated through the positive site.	Oxygen	9-15	Hap1p	Saccharomyces cerevisiae S288C	76-80
3579000-7	1987	Rats exposed to 80% oxygen had significantly decreased body weight, increased lung-to-body weight ratios, and increased levels of NPSH, CAT, GPx, total superoxide dismutase, and glutathione reductase by 11 days of treatment.	Oxygen	20-26	glutathione-disulfide reductase	Rattus norvegicus	178-199
3594945-1	1987	Myoglobin, an oxygen-binding protein, is synthesized exclusively in striated and cardiac muscle, and is normally found in blood.	Oxygen	14-20	myoglobin	Homo sapiens	0-9
11691886-14	2001	Oxygen extraction was higher during the first 60 s of EX2 and EX3 than in EX 1 and thigh oxygen uptake was elevated (P &lt; 0.05) during the first 120 s of EX2 and throughout EX3 compared to EX1.	Oxygen	89-95	FERM domain containing 6	Homo sapiens	191-194
29712147-1	2001	Through isoelectronic replacement of the oxygen atoms in SO42- ions by one CH2 and three NtBu groups one arrives formally at the dianion H2 CS(NtBu)32- , which has been isolated for the first time in the form of the sulfur(VI) ylide complex [(tmeda)2 Li2 {CH2 S(NtBu)3 }].	Oxygen	41-47	ATP binding cassette subfamily A member 12	Homo sapiens	251-254
11500414-5	2001	The inhibitory effect of oxygen on expression of CPS in O variants correlated with decreased tyrosine phosphorylation of CpsD, a tyrosine kinase and regulator of CPS synthesis.	Oxygen	25-31	cathepsin D	Homo sapiens	121-125
11536448-2	2001	We hypothesized that MnSOD increases in human lung in response to oxygen treatment, although this response could be restricted to certain cell types and depend on gestational age.	Oxygen	66-72	superoxide dismutase 2	Homo sapiens	21-26
11536448-9	2001	However, the inability to induce MnSOD in response to oxygen treatment may result in a poor outcome.	Oxygen	54-60	superoxide dismutase 2	Homo sapiens	33-38
11513604-12	2001	A crystal structure of the complex of RNase A with 2"-deoxyuridine 3"-pyrophosphate (P"--&gt;5") adenosine (dUppA), determined at 1.7 A resolution, together with models of the UppA complex based on this structure suggest that His119 contributes to UppA cleavage through a hydrogen bond with a nonbridging oxygen atom in the pyrophosphate and through pi-pi stacking with the six-membered ring of adenine.	Oxygen	305-311	ribonuclease A family member 1, pancreatic	Homo sapiens	38-45
11526493-9	2001	Two amino acid substitutions (Pro582Ser and Ala588Thr) were identified in the oxygen-dependent degradation/pVHL binding domain of HIF-1alpha, however neither substitution was observed exclusively in tumour samples.	Oxygen	78-84	von Hippel-Lindau tumor suppressor	Homo sapiens	107-111
11531124-1	2001	The mechanism of the gas-phase reaction of *CH2OH+O2 to form CH2O+HO2* was studied theoretically by means of high-level quantum-chemical electronic structure methods (CASSCF and CCSD(T)).	Oxygen	50-52	heme oxygenase 2	Homo sapiens	66-69
11454556-10	2001	These data support a role of differential O2 tension in the penis in the smooth muscle synthesis of PGE2, which in turn increases cAMP synthesis via EP2 receptors.	Oxygen	42-44	prostaglandin E receptor 2	Homo sapiens	149-152
11472975-10	2001	In situ hybridization studies demonstrated increases in SP-D, and to a lesser extent in SP-A, in peripheral lung tissues from oxygen-exposed newborns.	Oxygen	126-132	surfactant protein D	Rattus norvegicus	56-60
11438210-6	2001	RESULTS: The proportions of cells expressing the early Mk marker CD41a and the late Mk marker CD42a at day 15 were 4 and 5 times higher, respectively, at 20% O2.	Oxygen	158-160	glycoprotein IX platelet	Homo sapiens	94-99
11438210-7	2001	CD41a and CD42a protein levels per cell were also higher at 20% O2.	Oxygen	64-66	glycoprotein IX platelet	Homo sapiens	10-15
11438210-9	2001	The proportion of IL-3 receptor (IL-3R)++ Mks at day 5 was 1.5 times higher at 5% O2.	Oxygen	82-84	interleukin 3 receptor subunit alpha	Homo sapiens	18-31
11438210-9	2001	The proportion of IL-3 receptor (IL-3R)++ Mks at day 5 was 1.5 times higher at 5% O2.	Oxygen	82-84	interleukin 3 receptor subunit alpha	Homo sapiens	33-38
11438210-15	2001	E2F-1, a ubiquitously expressed cell cycle transcription factor, was expressed at a 1.5-fold higher level at 20% O2 on day 6, but this difference did not persist by day 9.	Oxygen	113-115	E2F transcription factor 1 L homeolog	Xenopus laevis	0-5
11531102-11	2001	The results confirm that covalent binding of the CCl3* radical to cell components initiates the inhibition of lipoprotein secretion and thus steatosis, whereas reaction with oxygen, to form CCl3-OO*, initiates lipid peroxidation.	Oxygen	174-180	C-C motif chemokine ligand 3	Rattus norvegicus	190-194
11412102-1	2001	The recently determined crystal structures of bacterial and bovine cytochrome c oxidases show an area of organized water within the protein immediately above the active site where oxygen chemistry occurs.	Oxygen	180-186	LOC104968582	Bos taurus	67-79
11423121-0	2001	Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death.	Oxygen	76-82	mitogen activated protein kinase 14	Rattus norvegicus	14-21
11356890-1	2001	Sympathoexcitatory reticulospinal neurons of the rostral ventrolateral medulla (RVLM) are oxygen detectors excited by hypoxia to globally elevate regional cerebral blood flow (rCBF).	Oxygen	90-96	CCAAT/enhancer binding protein zeta	Rattus norvegicus	176-180
6295220-7	1982	Changes in these ACE activities preceded those of arterial oxygen tension and base transthoracic electrical impedance.	Oxygen	59-65	angiotensin I converting enzyme	Canis lupus familiaris	17-20
11371635-9	2001	We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP.	Oxygen	26-32	RAS p21 protein activator 1	Homo sapiens	93-100
6816769-4	1982	On elevated CO2, MASK exaggerated VT increase with little change in f. Increased VE and VT/TI were thus due to increased VT. During low O2 on MASK, both VT and f increased.	Oxygen	13-15	ankyrin repeat and KH domain containing 1	Homo sapiens	17-21
6289709-9	1982	Percent metabolism was unaltered during the next 72 h. However, in test animals, ACE activity, as reflected by BPAP metabolism, was significantly reduced after 16 h of exposure to oxygen (77 +/- 2%, p less than 0.01) and continued to decrease to a nadir of 66 +/- 3% at 40 h. Single-pass lung uptake of 14C-5-HT (77 +/- 2%) was unchanged throughout the 72-h period in air-exposed rabbits.	Oxygen	180-186	angiotensin-converting enzyme	Oryctolagus cuniculus	81-84
6289709-11	1982	Light and electron microscopy of lungs from oxygen-exposed rabbits demonstrating reduced 5-HT removal and ACE activity at 24 h revealed normal endothelial and type I cell morphologic features.	Oxygen	44-50	angiotensin-converting enzyme	Oryctolagus cuniculus	106-109
11355942-12	2001	Addition of insulin-like growth factor-1 also increased levels of VEGF under normoxic conditions in the mutant cells and no further increase was seen when added to cells exposed to 0.1% oxygen, indicating that levels of VEGF were already maximally stimulated.	Oxygen	186-192	insulin-like growth factor 1	Mus musculus	12-40
11376856-7	2001	With a lesioning protocol that elicits minimal injury in wild-types (ligation+40 min 10% O2), there was an attenuation of hypoxia-ischemia-induced MCP-1 production at 8 h post-hypoxia; in contrast, in animals that underwent longer periods of hypoxia-ischemia the magnitude of injury-induced induced MCP-1 production did not differ between wild-type and ICE -/- animals.	Oxygen	89-91	caspase 1	Mus musculus	353-356
6282878-15	1982	The dissimilarities observed between P-450 and myoglobin in their reactivity toward sulfur donor ligands at least partly reflect the variation in heme iron electron density resulting from their different endogenous axial ligands and may, in turn, help to explain their respective physiological functions of oxygen activation and reversible oxygen binding.	Oxygen	307-313	myoglobin	Homo sapiens	47-56
6282878-15	1982	The dissimilarities observed between P-450 and myoglobin in their reactivity toward sulfur donor ligands at least partly reflect the variation in heme iron electron density resulting from their different endogenous axial ligands and may, in turn, help to explain their respective physiological functions of oxygen activation and reversible oxygen binding.	Oxygen	340-346	myoglobin	Homo sapiens	47-56
11460349-0	2001	[Long-term oxygen inhalation therapy of COPD].	Oxygen	11-17	COPD	Homo sapiens	40-44
7085668-0	1982	Incorporation of molecular oxygen into pyrimidine cofactors by phenylalanine hydroxylase.	Oxygen	27-33	phenylalanine hydroxylase	Rattus norvegicus	63-88
7085668-9	1982	The majority of divicine isolated from phenylalanine hydroxylase incubations with o-methyl substrate analog was labeled with oxygen from 18O2.	Oxygen	125-131	phenylalanine hydroxylase	Rattus norvegicus	39-64
7085668-10	1982	The demonstration, with phenylalanine hydroxylase, that one atom of molecular oxygen remains attached to position 5 of pyrimidine cofactor, provides the first strong evidence for activation of oxygen by aromatic amino acid monooxygenases via covalent addition to C4a of tetrahydrobiopterin.	Oxygen	78-84	phenylalanine hydroxylase	Rattus norvegicus	24-49
7085668-10	1982	The demonstration, with phenylalanine hydroxylase, that one atom of molecular oxygen remains attached to position 5 of pyrimidine cofactor, provides the first strong evidence for activation of oxygen by aromatic amino acid monooxygenases via covalent addition to C4a of tetrahydrobiopterin.	Oxygen	193-199	phenylalanine hydroxylase	Rattus norvegicus	24-49
11399100-10	2001	Interleukin 1beta, transforming growth factor beta and connective tissue growth factor were all up-regulated by low oxygen tensions, as was beta1 integrin.	Oxygen	116-122	interleukin 1 beta	Bos taurus	0-50
2882183-3	1987	The concentration of GST was significantly increased after anaesthesia in patients who received halothane in 30% oxygen/70% nitrous oxide (n = 37) and in patients who received halothane in 100% oxygen (n = 17).	Oxygen	113-119	glutathione S-transferase kappa 1	Homo sapiens	21-24
2882183-3	1987	The concentration of GST was significantly increased after anaesthesia in patients who received halothane in 30% oxygen/70% nitrous oxide (n = 37) and in patients who received halothane in 100% oxygen (n = 17).	Oxygen	194-200	glutathione S-transferase kappa 1	Homo sapiens	21-24
11399100-10	2001	Interleukin 1beta, transforming growth factor beta and connective tissue growth factor were all up-regulated by low oxygen tensions, as was beta1 integrin.	Oxygen	116-122	cellular communication network factor 2	Bos taurus	55-86
11439121-8	2001	We discuss the possibility that the increased sensitivity of the uvh3 mutant to H2O2 and the premature senescence phenotype might result from failure to repair oxygen damage in plant tissues.	Oxygen	160-166	5'-3' exonuclease family protein	Arabidopsis thaliana	65-69
3604297-7	1987	Iron is of central importance among these active substances, since its presence in haemoglobin is essential for the transport of oxygen and carbon dioxide, makes it possible for myoglobin to function as an oxygen supply depot and guarantees the functioning of internal respiration in the respiratory chain and various key enzymes.	Oxygen	206-212	myoglobin	Homo sapiens	178-187
11278550-1	2001	Manganese superoxide dismutase (Mn-SOD) is a primary antioxidant enzyme whose expression is essential for life in oxygen.	Oxygen	114-120	superoxide dismutase 2	Homo sapiens	32-38
3098772-0	1987	Human corticotropin-releasing hormone in man: dose-response of minute ventilation and end-tidal partial pressures of carbon dioxide and oxygen.	Oxygen	136-142	corticotropin releasing hormone	Homo sapiens	6-37
3098772-11	1987	End-tidal partial pressure of oxygen, i.e. the most sensitive parameter for the duration of action of respiratory stimulation, was elevated for 8.5, 10.2, and 14 min after injection of 33, 67, or 100 micrograms hCRH.	Oxygen	30-36	corticotropin releasing hormone	Homo sapiens	211-215
11386681-1	2001	To describe the action mechanisms of Bacteriochlorin a (BCA), a second generation photosensitizer, in phosphate buffer (PB) and in dimyristoyl phosphatidylcholine (DMPC) liposomes we carried out oxygen consumption and ESR measurements.	Oxygen	195-201	B cell linker	Homo sapiens	37-54
3104298-3	1987	Pdi was measured under base-line conditions (50% O2-50% N2) and after 10 min of hypercapnia induced by breathing 5, 10, or 15% CO2 balanced with N2 and 50% O2.	Oxygen	49-51	peptidyl arginine deiminase 1	Homo sapiens	0-3
11386681-2	2001	In PB, where BCA was in a monomer-dimer equilibrium, our results suggested that the oxygen consumption was related to the BCA monomers concentration in solution.	Oxygen	84-90	B cell linker	Homo sapiens	13-16
11386681-2	2001	In PB, where BCA was in a monomer-dimer equilibrium, our results suggested that the oxygen consumption was related to the BCA monomers concentration in solution.	Oxygen	84-90	B cell linker	Homo sapiens	122-125
11386681-3	2001	Incorporation of BCA in DMPC liposomes, by promoting the monomerization of BCA, increased 9-fold the oxygen consumption in comparison to the value in PB.	Oxygen	101-107	B cell linker	Homo sapiens	17-20
3021865-1	1986	Oxygen metabolism and calcium ion (Ca++) handling in blood monocytes were greatly affected by treatment with recombinant gamma interferon (rIFN-gamma).	Oxygen	0-6	interferon gamma	Rattus norvegicus	139-149
11386681-3	2001	Incorporation of BCA in DMPC liposomes, by promoting the monomerization of BCA, increased 9-fold the oxygen consumption in comparison to the value in PB.	Oxygen	101-107	B cell linker	Homo sapiens	75-78
11386681-4	2001	The use of specific singlet oxygen quenchers (Azide and 9,10-Anthracenedipropionic acid) in ESR and oxygen consumption experiments allowed us to assert that BCA was mainly a type II sensitizer when it was incorporated in DMPC.	Oxygen	28-34	B cell linker	Homo sapiens	157-160
11316909-12	2001	CONCLUSION: Forty-two-day-old AS-1 RBCs that have been rejuvenated and then frozen have more than 75 percent viability and normal oxygen delivery function.	Oxygen	130-136	prostaglandin D2 receptor	Homo sapiens	30-34
3463991-4	1986	Oxygen further stimulated the effectiveness of thioredoxin severalfold.	Oxygen	0-6	thioredoxin	Homo sapiens	47-58
11179510-5	2001	The increase in MnSOD in the presence of Fe(3+)-NTA was greater under the condition of 20% O(2) than under the condition of 1% O(2).	Oxygen	127-131	superoxide dismutase 2	Homo sapiens	16-21
3091694-12	1986	These active oxygen species also seemed to be generated by mast cells, because these enzymes caused an increase in 5-lipoxygenase products when mast cells were challenged alone.	Oxygen	13-19	arachidonate 5-lipoxygenase	Rattus norvegicus	115-129
11254668-0	2001	Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster.	Oxygen	83-85	Adenosine deaminase	Drosophila melanogaster	21-40
3017933-5	1986	The intermediacy of superoxide anion, formed by the one-electron reduction of molecular oxygen, established that alkylation of cytochrome P-450c with BrNAP uncouples the catalytic cycle prior to introduction of the second electron.	Oxygen	88-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	127-144
3091386-8	1986	The production of erythropoietin (epo), present in the culture supernatants, increased as the oxygen concentration increased from 2% to 3.5%, but then decreased as the oxygen concentration was increased further, from 3.5% to 5%.	Oxygen	94-100	erythropoietin	Mus musculus	18-32
3091386-8	1986	The production of erythropoietin (epo), present in the culture supernatants, increased as the oxygen concentration increased from 2% to 3.5%, but then decreased as the oxygen concentration was increased further, from 3.5% to 5%.	Oxygen	94-100	erythropoietin	Mus musculus	34-37
11163147-2	2001	pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen.	Oxygen	86-92	von Hippel-Lindau tumor suppressor	Homo sapiens	0-4
3091386-8	1986	The production of erythropoietin (epo), present in the culture supernatants, increased as the oxygen concentration increased from 2% to 3.5%, but then decreased as the oxygen concentration was increased further, from 3.5% to 5%.	Oxygen	168-174	erythropoietin	Mus musculus	18-32
3091386-8	1986	The production of erythropoietin (epo), present in the culture supernatants, increased as the oxygen concentration increased from 2% to 3.5%, but then decreased as the oxygen concentration was increased further, from 3.5% to 5%.	Oxygen	168-174	erythropoietin	Mus musculus	34-37
3745041-10	1986	WB measurements of Hb O2 uptake under simulated physiological conditions are characterized by a net decrease in partial molal volume on oxygenation of 30-35 ml/mol Hb4.	Oxygen	22-24	keratin 84	Homo sapiens	164-167
3090012-8	1986	When O2 consumption exceeded about 2.7 1/min, evidence for DIFF at sea level was present (P = 0.01).	Oxygen	5-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	67-70
3085590-6	1986	Modification of phosphoenolpyruvate carboxylase in the light under an oxygen atmosphere resulted in an irreversible inactivation, which was completely protected by phosphoenolpyruvate and MgCl2.	Oxygen	70-76	MLO-like protein 4	Zea mays	16-47
11293550-1	2001	The heme of neuronal nitric oxide synthase (nNOS) participates in O2 activation but also binds self-generated NO, resulting in reversible feedback inhibition.	Oxygen	66-68	nitric oxide synthase 1	Homo sapiens	12-42
3710979-4	1986	Pdi was measured under base-line conditions [inspired O2 fractional concentration (FIO2) = 0.50] and after 10 min of hypoxemia induced by breathing 12-14% FIO2.	Oxygen	54-56	peptidyl arginine deiminase 1	Homo sapiens	0-3
3719069-7	1986	The drop in oxygen tension from fiber periphery to core, however, does depend significantly on the myoglobin concentration, the oxygen tension level at the sarcolemma, and the oxygen and myoglobin diffusivities.	Oxygen	12-18	myoglobin	Homo sapiens	187-196
11293550-1	2001	The heme of neuronal nitric oxide synthase (nNOS) participates in O2 activation but also binds self-generated NO, resulting in reversible feedback inhibition.	Oxygen	66-68	nitric oxide synthase 1	Homo sapiens	44-48
11032835-5	2001	The membrane fraction of kidney-derived human embryonic kidney (HEK) 293 cells, expressing NOX4, exhibits NADH- and NADPH-dependent superoxide-producing activities, both of which are inhibited by diphenylene iodonium, an agent known to block oxygen sensing, and decreased in cells expressing antisense NOX4 mRNA.	Oxygen	242-248	NADPH oxidase 4	Homo sapiens	91-95
3949114-2	1986	Because reports have appeared suggesting that hyperbaric O2 treatment protects against the hepatotoxicity of CCl4 in humans, studies were undertaken in rats to assess this possibility and to explore its mechanism.	Oxygen	57-59	C-C motif chemokine ligand 4	Homo sapiens	109-113
3949114-12	1986	Because the mechanism of CCl4 hepatotoxicity is thought to be the same in the rat and in humans, hyperbaric O2 therapy is recommended for treatment of CCl4 poisoning in humans.	Oxygen	108-110	C-C motif chemokine ligand 4	Homo sapiens	151-155
11032835-9	2001	The present findings thus suggest that the novel NAD(P)H oxidase NOX4 may serve as an oxygen sensor and/or a regulator of cell growth in kidney.	Oxygen	86-92	NADPH oxidase 4	Homo sapiens	65-69
11995966-3	2001	Here we show that the lethality of rrd1,2delta is also suppressed under oxygen-limited conditions.	Oxygen	72-78	peptidylprolyl isomerase RRD1	Saccharomyces cerevisiae S288C	35-46
3702644-1	1986	It has been generally accepted that during exercise at sea level, the pulmonary system of normal, healthy individuals is capable of maintaining arterial oxygen tension at near resting levels.	Oxygen	153-159	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
11131852-7	2000	Patient education and oxygen can improve the quality and duration of life in early and advanced stages of COPD.	Oxygen	22-28	COPD	Homo sapiens	106-110
3006503-5	1986	5: 141-195, 1969) to determine whether these parameters could account for the experimentally measured O2 dependence curves for myoglobin (Mb) oxygenation and cytochrome a + a3 oxidation in heart cells.	Oxygen	102-104	myoglobin	Homo sapiens	127-136
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Oxygen	132-138	complement C2	Homo sapiens	69-77
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Oxygen	132-138	complement C2	Homo sapiens	69-72
11123679-1	2000	The Escherichia coli cydAB operon, encoding the subunits of the high-affinity cytochrome d oxidase, is maximally transcribed in microaerobiosis as a result of the combined action of the oxygen-responsive regulators Fnr and ArcA.	Oxygen	186-192	arginine deiminase	Escherichia coli	223-227
22175479-0	1986	Rhodium-rhodium stretching frequencies in oxygen-16, oxygen-18, and trideuteromethyl derivatives of Rh2(O2CCH3)4(PPh3)2.	Oxygen	42-48	Rh associated glycoprotein	Homo sapiens	100-103
22175479-0	1986	Rhodium-rhodium stretching frequencies in oxygen-16, oxygen-18, and trideuteromethyl derivatives of Rh2(O2CCH3)4(PPh3)2.	Oxygen	42-48	protein phosphatase 4 catalytic subunit	Homo sapiens	113-117
11123679-7	2000	According to this model, ArcA-P plays a central role in cydAB regulation by antagonizing H-NS repression of cydAB transcription when oxygen becomes limiting.	Oxygen	133-139	arginine deiminase	Escherichia coli	25-29
22175479-0	1986	Rhodium-rhodium stretching frequencies in oxygen-16, oxygen-18, and trideuteromethyl derivatives of Rh2(O2CCH3)4(PPh3)2.	Oxygen	53-59	Rh associated glycoprotein	Homo sapiens	100-103
11087382-5	2000	The oxygen affinity (P(50) = 0.45 Torr) is similar to that of myoglobin.	Oxygen	4-10	myoglobin	Physeter catodon	62-71
3471106-0	1986	Dynamic simulations of oxygen binding to myoglobin.	Oxygen	23-29	myoglobin	Homo sapiens	41-50
3471106-1	1986	We report dynamic simulations of the process by which a dioxygen molecule enters or leaves the heme pocket region of myoglobin along a path between the distal histidine (E7) and valine (E11).	Oxygen	56-64	myoglobin	Homo sapiens	117-126
11013136-1	2000	Cytochrome c oxidase (COX) catalyzes both electron transfer from cytochrome c to molecular oxygen and the concomitant vectorial proton pumping across the inner mitochondrial membrane.	Oxygen	91-97	cytochrome c oxidase subunit 8A	Homo sapiens	22-25
11035728-10	2000	This porin-induced downregulation of oxidative metabolism may be a potent mechanism by which gonococci modulate oxygen-dependent reactions by activated phagocytes at inflammation sites.	Oxygen	112-118	voltage dependent anion channel 1	Homo sapiens	5-10
3515507-11	1986	Our results could suggest the implication of Mb as a source of oxygen in the thyroid peroxidase system rather than in exocytotic-endocytotic processes.	Oxygen	63-69	myoglobin	Homo sapiens	45-47
3949151-5	1986	Furthermore, in the striatum, it was shown that catechol-O-methyl transferase, up to now considered unaffected by hypoxia, may also be altered by oxygen deficiency.	Oxygen	146-152	catechol-O-methyltransferase	Rattus norvegicus	48-77
7069705-4	1982	The inactivation of COMT by these agents could be prevented by excluding oxygen from the incubation of mixtures, indicating the necessity for their oxidation to the corresponding aminochromes.	Oxygen	73-79	catechol-O-methyltransferase	Rattus norvegicus	20-24
11078373-3	2000	In the study reported here, we investigated the more chronic effects of hypoxia (10% O2 for 4 weeks) on renin gene expression and the influence of the ET system on its regulation.	Oxygen	85-87	renin	Rattus norvegicus	104-109
7037714-3	1982	We hypothesized that since oxygen tension modulates ACE activity, the high pulmonary oxygen tension and hence high ACE activity protects the lung from the edematogenic effects of BK.	Oxygen	27-33	angiotensin-converting enzyme	Ovis aries	52-55
7037714-3	1982	We hypothesized that since oxygen tension modulates ACE activity, the high pulmonary oxygen tension and hence high ACE activity protects the lung from the edematogenic effects of BK.	Oxygen	27-33	angiotensin-converting enzyme	Ovis aries	115-118
6301325-2	1982	The endothelial cell, both in the lung and in systemic tissues, is uniquely situated to detect changes in ambient oxygen tension; thereafter, as exemplified by the effects of altered oxygen tension on ACE, the cell is capable of initiating changes that modulate its functions to reflect the altered physiologic state.	Oxygen	114-120	angiotensin-converting enzyme	Ovis aries	201-204
6301325-2	1982	The endothelial cell, both in the lung and in systemic tissues, is uniquely situated to detect changes in ambient oxygen tension; thereafter, as exemplified by the effects of altered oxygen tension on ACE, the cell is capable of initiating changes that modulate its functions to reflect the altered physiologic state.	Oxygen	183-189	angiotensin-converting enzyme	Ovis aries	201-204
6301325-4	1982	Integrity of the endothelial cell membrane is necessary for the modulating changes to occur, and indeed, ACE purified from the cell is insensitive to changes in oxygen tension: it is the cell, not the enzyme, that responds to changes in oxygen tension (FIGURE 5).	Oxygen	237-243	angiotensin-converting enzyme	Ovis aries	105-108
7131592-2	1982	Phospholipase A2 initially caused an increase of synaptosome respiration and subsequently inhibited their oxygen uptake, but this effect was completely abolished in BSA-containing media.	Oxygen	106-112	phospholipase A2	Apis mellifera	0-16
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	47-54	complement C4A (Rodgers blood group)	Homo sapiens	70-73
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	217-224	complement C4A (Rodgers blood group)	Homo sapiens	70-73
3473608-10	1986	While a significant correlation was found between maximal oxygen uptake and red cell volume at sea level, the hematologic response to altitude seemed independent on physical fitness.	Oxygen	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
4066735-1	1985	This work was done to evaluate the transcutaneous oxygen tension (TcPO2) in ischaemic legs introducing two variables: O2 breathed at 40% and heating with an electric blanket (HEB).	Oxygen	50-56	transcription factor 12	Homo sapiens	175-178
4066735-7	1985	In the RP group significant differences were obtained when the HEB was used whether the patient was breathing ambient O2 or at 40%.	Oxygen	118-120	transcription factor 12	Homo sapiens	63-66
21423825-4	2000	Lys41 of RNase A is known to donate a hydrogen bond to a nonbridging phosphoryl oxygen in the transition state during catalysis.	Oxygen	80-86	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
4075324-4	1985	The binding of Gd3+ to these model compounds containing N-terminal blocking groups and esterified carboxyl groups indicates that the disaccharide contains a rather weak, but unique, binding-site in the vicinity of C-2 of alpha-D-GalNAc (possibly involving N-2", the acetamido carbonyl group, O-3" and/or possibly the glycosidic oxygen atom (O-3)).	Oxygen	328-334	complement C2	Homo sapiens	214-217
3840372-3	1985	The observation suggests that the oxygenation of sulfide with FAD-containing monooxygenase involves the nucleophilic attack of the divalent sulfur on the reactive oxygen atom involved at the enzyme active site, namely electrophilic oxygenation of sulfide, though the oxygenation with the cytochrome P-450 is initiated by a single electron transfer from the sulfide to the enzyme active species.	Oxygen	34-40	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	288-304
7262071-4	1981	This establishes a role for cytochrome b5 in donating electrons for the reduction of oxy-cytochrome P-450 to the active oxygen complex of cytochrome P-450 but also points to large variations in the importance of this role depending on the experimental conditions, the species of P-450 involved and the substrates employed.	Oxygen	120-126	cytochrome b5 type A	Homo sapiens	28-41
11043580-10	2000	In addition, mRNAs for the helix-loop-helix factors Mash-2 (mammalian achaete-scute homologous protein-2) and Id1 (inhibitor of differentiation 1) were readily detectable in freshly isolated cytotrophoblasts and were markedly decreased upon differentiation to syncytiotrophoblast in 20% O2.	Oxygen	287-289	inhibitor of DNA binding 1, HLH protein	Homo sapiens	110-113
6454443-11	1981	Oxygen exchange measurements made during the burst and steady state at 25 degrees C indicate that the mechanism of hydrolysis is essentially the same for both, but that there is a higher effective actin concentration around the myosin sites in the original form.	Oxygen	0-6	myosin heavy chain 14	Homo sapiens	228-234
3862132-0	1985	Genetic differences in oxygen toxicity are correlated with cytochrome P-450 inducibility.	Oxygen	23-29	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	59-75
11043580-10	2000	In addition, mRNAs for the helix-loop-helix factors Mash-2 (mammalian achaete-scute homologous protein-2) and Id1 (inhibitor of differentiation 1) were readily detectable in freshly isolated cytotrophoblasts and were markedly decreased upon differentiation to syncytiotrophoblast in 20% O2.	Oxygen	287-289	inhibitor of DNA binding 1, HLH protein	Homo sapiens	115-145
3862132-2	1985	Because in vitro studies have shown that the cytochrome P-450 enzymes can produce oxygen radicals and H2O2, we tested the hypothesis that inducibility of these enzymes might play a role in oxygen toxicity.	Oxygen	82-88	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-61
3862132-5	1985	Lung and liver cytochrome P-450 levels increased 2-to 3-fold in C3H and F1 mice during 100% oxygen exposure (maximum levels at 72-96 hr) and subsequently fell prior to death.	Oxygen	92-98	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	15-31
7032212-0	1981	A gonadotrophin-releasing hormone agonist stimulates oxygen consumption and maturation of follicle-enclosed rat oocytes in vitro.	Oxygen	53-59	gonadotropin releasing hormone 1	Rattus norvegicus	2-33
11017142-2	2000	Skeletal muscle oxygen consumption was 98% higher in Ucp-L mice (with low expression) and 246% higher in Ucp-H mice (with high expression) than in wild-type mice.	Oxygen	16-22	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	53-56
7262818-11	1981	The delta 6-desaturase activity required NADH (or NADPH), linoleoyl-CoA, oxygen, lipid or detergent and three enzymes, such as NADH-cytochrome b5 reductase (or NADPH-cytochrome P -450 reductase), cytochrome b5, and delta 6-desaturase.	Oxygen	73-79	fatty acid desaturase 2	Rattus norvegicus	4-22
4001604-0	1985	Erythropoietin production in normoxic and hypoxic rats with increased blood O2 affinity.	Oxygen	76-78	erythropoietin	Rattus norvegicus	0-14
4001604-1	1985	Effects of an acute increase in blood O2 affinity on erythropoietin production were studied in normoxic and hypoxic male rats.	Oxygen	38-40	erythropoietin	Rattus norvegicus	53-67
4001604-6	1985	Plasma erythropoietin titers were significantly enhanced in rats with high blood O2 affinity at 300 m (0.05 +/- 0.01 U/ml; n = 4) and moderately increased at 4750 m (0.57 +/- 0.12 U/ml; n = 7), but unchanged at 7000 m (3.88 +/- 0.74 U/ml; n = 10).	Oxygen	81-83	erythropoietin	Rattus norvegicus	7-21
7213661-0	1980	Hemoglobin Milledgeville (alpha 44 (CD2) Pro leads to Leu): a new variant with increased oxygen affinity.	Oxygen	89-95	CD2 molecule	Homo sapiens	36-39
4001604-7	1985	These results indicate that a high blood O2 affinity reduces the O2 delivery to the cells controlling erythropoietin production in normoxia and moderate hypoxia.	Oxygen	41-43	erythropoietin	Rattus norvegicus	102-116
4001604-7	1985	These results indicate that a high blood O2 affinity reduces the O2 delivery to the cells controlling erythropoietin production in normoxia and moderate hypoxia.	Oxygen	65-67	erythropoietin	Rattus norvegicus	102-116
3970817-5	1985	Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC.	Oxygen	109-115	serpin family B member 3	Homo sapiens	230-233
3970817-5	1985	Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC.	Oxygen	177-183	serpin family B member 3	Homo sapiens	230-233
7459380-7	1980	Since these spectral changes occur in two metal flavin complexes with very different electronic spectra, they would seem to be due to vibrational changes induced by metal complexation at N-5 and the oxygen at C-4 of flavin rather than the details of the vibronic interactions which give rise to the resonance enhancement of the spectrum.	Oxygen	199-205	complement C4A (Rodgers blood group)	Homo sapiens	209-212
6997310-5	1980	The catechol O-methyltransferase reaction thus involves a direct transfer of the methyl group from the sulfur of AdoMet to the oxygen of the catechol in an SN2 process, without a methylated enzyme intermediate.	Oxygen	127-133	catechol-O-methyltransferase	Rattus norvegicus	4-32
11017142-2	2000	Skeletal muscle oxygen consumption was 98% higher in Ucp-L mice (with low expression) and 246% higher in Ucp-H mice (with high expression) than in wild-type mice.	Oxygen	16-22	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	105-108
11027709-8	2000	Experiments with ruthenium red, which is a blocker of Ca(2+) fluxes in rice as well as maize (Zea mays), suggest that the induction of expression of Adh1 and Pdc1 by low oxygen stress is regulated by elevation of the cytosolic Ca(2+) level.	Oxygen	170-176	alcohol dehydrogenase 1	Zea mays	149-153
6159842-5	1980	The central chemosensitivity (SCO2), defined as the ratio between change in ventilation (delta V) and delta PETCO2, was assessed either by transient inhalation of gas mixtures containing 5 to 8% CO2 in pure O2 ("varying transients") or by progressive hypercapnia (rebreathing in pure O2).	Oxygen	112-114	synthesis of cytochrome C oxidase 2	Homo sapiens	30-34
2410562-1	1985	Using an optically transparant thin layer electrode, it has been possible to measure the pH changes associated with the electrochemical turnover of horse heart cytochrome c in the presence of rat liver mitochondria and oxygen.	Oxygen	219-225	cytochrome c, somatic	Equus caballus	160-172
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Oxygen	192-198	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-31
3924036-3	1985	The antimycin A-resistant oxygen uptake was further inhibited by the lipoxygenase inhibitors salicylhydroxamic acid, 5,8,11,14-eicosatetraynoic acid, nordihydroguaiaretic acid, 4-nitrocatechol or propylgallate by about 20-30% corresponding to 5-7% of the total oxygen uptake.	Oxygen	26-32	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	69-81
3924036-6	1985	Influx of calcium ions mediated by the ionophore A 23187 led to a two-fold increase in the non-respiratory oxygen uptake which was mainly due to stimulation of the lipoxygenase reaction.	Oxygen	107-113	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	164-176
3939140-3	1985	To understand fully the interaction between reactive oxygen metabolites, myoglobin and lipid, we investigate the possibility that myoglobin may use xanthine oxidase-generated superoxide and/or hydrogen peroxide to catalyze peroxidation of a polyunsaturated fatty acid.	Oxygen	53-59	myoglobin	Homo sapiens	130-139
6769526-1	1980	1 Exposure of guinea-pigs to a CO2-enriched atmosphere (20% CO2, 25% O2, 55% N2) for 1 to 5 h caused a marked, progressive increase of plasma dopamine beta-hydroxylase (DBH) activity which reached its peak after 2 h of CO2 exposure and then gradually decreased.	Oxygen	32-34	dopamine beta-hydroxylase	Cavia porcellus	142-167
6769526-1	1980	1 Exposure of guinea-pigs to a CO2-enriched atmosphere (20% CO2, 25% O2, 55% N2) for 1 to 5 h caused a marked, progressive increase of plasma dopamine beta-hydroxylase (DBH) activity which reached its peak after 2 h of CO2 exposure and then gradually decreased.	Oxygen	32-34	dopamine beta-hydroxylase	Cavia porcellus	169-172
6768294-6	1980	Additionally, because Hb Alc increased in vitro oxygen affinity, some of these women were followed for parameters of oxygen transport as well.	Oxygen	48-54	allantoicase	Homo sapiens	25-28
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Oxygen	192-198	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	33-36
7221190-2	1980	The relationship between arterial oxygen pressure to Pap as to vascular resistance is not in the mean linear.	Oxygen	34-40	pancreatitis-associated protein	Canis lupus familiaris	53-56
10998102-0	2000	O2-sensing after carotid chemodenervation: hypoxic ventilatory responsiveness and upregulation of tyrosine hydroxylase mRNA in brainstem catecholaminergic cells.	Oxygen	0-2	tyrosine hydroxylase	Rattus norvegicus	98-118
43987-0	1979	[Fully automatous determination of acid-base balance and partial pressures of O2 and CO2 in the blood with ABL 2 (author"s transl)].	Oxygen	78-80	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	107-112
6529512-1	1984	The oxygen affinity of washed red cells suspended in their own plasma or in CSF has been studied to demonstrate a possible effect of CSF on the oxygen affinity of human haemoglobin.	Oxygen	144-150	colony stimulating factor 2	Homo sapiens	133-136
6529512-2	1984	The CSF was found to reduce the oxygen affinity of haemoglobin significatively, and this was not imputable to the action of pH, PCO2, temperature, 2,3DPG A hypothesis to explain the data found and their clinical interest towards the regulation of brain oxygenation was formulated considering the Monod-Wyman-Changeux model and the effect of solutions on proteins.	Oxygen	32-38	colony stimulating factor 2	Homo sapiens	4-7
10998102-10	2000	O2-sensing mechanisms unmasked by carotid chemodenervation triggered two ventilatory adjustments: (i) a partial acclimatization to long-term hypoxia associated with TH upregulation; (ii) a complete restoration of acute hypoxic responsivity independent of TH upregulation.	Oxygen	0-2	tyrosine hydroxylase	Rattus norvegicus	165-167
10998102-10	2000	O2-sensing mechanisms unmasked by carotid chemodenervation triggered two ventilatory adjustments: (i) a partial acclimatization to long-term hypoxia associated with TH upregulation; (ii) a complete restoration of acute hypoxic responsivity independent of TH upregulation.	Oxygen	0-2	tyrosine hydroxylase	Rattus norvegicus	255-257
11026686-4	2000	Protein conformational relaxations have been extensively investigated with myoglobin because the photosensivity of the adduct with CO, O2 and NO allows us to follow events related to the migration of the ligand through the matrix.	Oxygen	135-137	myoglobin	Physeter catodon	75-84
6085552-2	1984	ELAp has been calculated from the relationship between the oxygen deficit (Do2) and LAp in 32 subjects.	Oxygen	59-65	LAP	Homo sapiens	1-4
6085552-5	1984	This equation is: Do2 = 12.3 + 2.4 LAp (r = 0.958; P less than 0.001), where Do2 is expressed in ml O2/kg and LAp in mmol/litre (mM).	Oxygen	100-102	LAP	Homo sapiens	35-38
6535313-5	1984	The oxygen partial pressure in the apparatus was controlled at 0.209 +/- 0.003 atm.	Oxygen	4-10	ATM serine/threonine kinase	Homo sapiens	79-82
444478-2	1979	These cells produce large amounts of lactic acid, and oxygen consumption data indicate that the first complex of the electron transport chain, NADH-coenzyme Q reductase, is defective.	Oxygen	54-60	NADH:ubiquinone oxidoreductase core subunit S2	Mus musculus	143-168
227614-15	1979	The results indicate the formation of a BaP radical as an intermediate in the interaction of BaP with BSA and cysteine in the presence of oxygen and suggest the involvement of SH-groups in this interaction.	Oxygen	138-144	prohibitin 2	Homo sapiens	40-43
227614-15	1979	The results indicate the formation of a BaP radical as an intermediate in the interaction of BaP with BSA and cysteine in the presence of oxygen and suggest the involvement of SH-groups in this interaction.	Oxygen	138-144	prohibitin 2	Homo sapiens	93-96
153148-0	1978	Effect of actin concentration on the intermediate oxygen exchange of myosin; relation to the refractory state and the mechanism of exchange.	Oxygen	50-56	myosin heavy chain 14	Homo sapiens	69-75
153148-1	1978	The effect of actin concentration on the myosin catalyzed exchange of phosphate oxygens with water accompanying ATP hydrolysis has been investigated.	Oxygen	80-87	myosin heavy chain 14	Homo sapiens	41-47
10823831-1	2000	The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability, being required for the oxygen-dependent proteolysis of alpha subunits of hypoxia inducible factor-1 (HIF).	Oxygen	107-113	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
34094-2	1978	The myoglobin-like haemoprotein leghaemoglobin (Lb I) from lupine root nodules has a great affinity to molecular oxygen and seems to be involved in O2-transport.	Oxygen	113-119	myoglobin	Homo sapiens	4-13
34094-2	1978	The myoglobin-like haemoprotein leghaemoglobin (Lb I) from lupine root nodules has a great affinity to molecular oxygen and seems to be involved in O2-transport.	Oxygen	148-150	myoglobin	Homo sapiens	4-13
34094-3	1978	Some ligands of low molecular weight are supposed to affect the haemoglobin (Hb) and myoglobin (Mo) function in O2-transport.	Oxygen	112-114	myoglobin	Homo sapiens	85-94
10823831-1	2000	The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability, being required for the oxygen-dependent proteolysis of alpha subunits of hypoxia inducible factor-1 (HIF).	Oxygen	151-157	von Hippel-Lindau tumor suppressor	Homo sapiens	48-52
10931429-3	2000	KL-6 correlated with the alveolar-arterial oxygen tension difference on day 10 and day 30.	Oxygen	43-49	mucin 1, cell surface associated	Homo sapiens	0-4
101236-0	1978	Retention of the oxygens at C-2 and C-3 of D-ribulose 1,5-bisphosphate in the reaction catalyzed by ribulose-1,5-bisphosphate carboxylase.	Oxygen	17-24	complement C2	Homo sapiens	28-31
6334536-2	1984	Besides being of the utmost importance for determining species distributions for enzymatic studies, these constants allow an estimation of the preference of Cd2+ for sulfur vs. oxygen coordination in phosphorothioate complexes.	Oxygen	177-183	CD2 molecule	Homo sapiens	157-160
10748045-1	2000	Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids.	Oxygen	25-31	gamma-glutamyl carboxylase	Drosophila melanogaster	53-79
6385009-7	1984	One mutant, rox1-a1, is pleiotropic and causes constitutive expression of three oxygen-induced genes--CYC1, SOD (superoxide dismutase), and tr-1 (an oxygen-induced gene with homology to ANB1)--as well as constitutive expression of the oxygen-repressed ANB1 gene.	Oxygen	80-86	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	102-106
6609157-0	1984	Evidence from oxygen exchange studies that the two heads of myosin are functionally different.	Oxygen	14-20	myosin heavy chain 14	Homo sapiens	60-66
6609157-1	1984	Recent studies of oxygen exchange have shown that there are two normal pathways for the hydrolysis of MgATP by myosin in the presence of actin, each producing Pi at the same rate.	Oxygen	18-24	myosin heavy chain 14	Homo sapiens	111-117
6704150-2	1984	In atmospheric oxygen, DDT bound to microsomal protein; however, binding was increased up to approximately 70% by oxygen depletion.	Oxygen	15-21	D-dopachrome tautomerase	Rattus norvegicus	23-26
6704150-2	1984	In atmospheric oxygen, DDT bound to microsomal protein; however, binding was increased up to approximately 70% by oxygen depletion.	Oxygen	114-120	D-dopachrome tautomerase	Rattus norvegicus	23-26
6358411-3	1983	and (b) is copper-stimulated LHRH release a result of an interaction of copper with thiol groups and, if so, does it require oxygen?	Oxygen	125-131	gonadotropin releasing hormone 1	Rattus norvegicus	29-33
6416690-2	1983	It was shown that CCl3 radicals add oxygen to form CCl3O2 radicals, which eventually yield three chloride ions and CO2.	Oxygen	36-42	C-C motif chemokine ligand 3	Homo sapiens	18-22
6416690-4	1983	Competing reactions of the CCl3 radical increase this ratio at lower oxygen concentrations.	Oxygen	69-75	C-C motif chemokine ligand 3	Homo sapiens	27-31
657501-7	1978	We also present performance data for the routine SMAC glucose oxidase (EC 1.1.3.4)/Peroxidase (EC 1.11.1.7) 3-methyl-2-benzothianolinone hydrazone-N,N-dimethylaniline method, the direct hexokinase method with the Du Pont aca, and the glucose oxidase oxygen-rate method with the Beckman Glucose Analyzer.	Oxygen	250-256	diablo IAP-binding mitochondrial protein	Homo sapiens	49-53
684048-0	1978	[Determination of the oxygen permeability of plastic bottles using the SMZ 300 rod detector in connection with the M 65 F p02-meter.	Oxygen	22-28	tumor protein, translationally-controlled 1	Homo sapiens	122-125
641045-0	1978	Kinetics of oxygen-18 exchange between inorganic phosphate and water catalyzed by myosin subfragment 1, using the 18O shift in 31P NMR.	Oxygen	12-18	myosin heavy chain 14	Homo sapiens	82-88
641045-1	1978	The time course of oxygen-18 exchange between [18O]Pi and normal water, catalyzed by myosin subfragment 1 in the presence of MgADP, was followed using the shift in 31P NMR caused by the presence of oxygen-18 bound to the phosphorus.	Oxygen	19-25	myosin heavy chain 14	Homo sapiens	85-91
147338-4	1978	Accumulation was oxygen dependent, saturable and reduced in the presence of metabolic inhibitors (2,4-dinitrophenol and sodium azide) and other organic anions 1p-aminohippurate (PAH) and probenecid].	Oxygen	17-23	phenylalanine hydroxylase	Rattus norvegicus	178-181
643379-2	1978	Examination of the lungs of neonatal rats, who survived 5 days of oxygen exposure with no evidence of respiratory distress, showed significant increases in the pulmonary superoxide dismutase (SOD) activity (peak value: 144% of air-exposed controls), glutathione peroxidase (GP) activity (126%), glutathione reductase (GR) activity (122%), reduced glutathione (GSH) level (176%), and glucose-6-phosphate dehydrogenase activity (151%).	Oxygen	66-72	glutathione-disulfide reductase	Rattus norvegicus	295-316
643379-2	1978	Examination of the lungs of neonatal rats, who survived 5 days of oxygen exposure with no evidence of respiratory distress, showed significant increases in the pulmonary superoxide dismutase (SOD) activity (peak value: 144% of air-exposed controls), glutathione peroxidase (GP) activity (126%), glutathione reductase (GR) activity (122%), reduced glutathione (GSH) level (176%), and glucose-6-phosphate dehydrogenase activity (151%).	Oxygen	66-72	glutathione-disulfide reductase	Rattus norvegicus	318-320
588400-2	1977	The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%.	Oxygen	76-82	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	16-21
588400-3	1977	A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more markedly (by 75.9%).	Oxygen	83-89	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	13-18
336081-0	1977	Comparative studies of oxygen exchange catalyzed by myosin, heavy meromyosin, and subfragment 1.	Oxygen	23-29	myosin heavy chain 14	Homo sapiens	52-58
199885-5	1977	After beta1-adrenoreceptor blockade these increases were reduced to 33 +/- 4 and 41 +/- 3% O2-S saturation, respectively.	Oxygen	91-95	adrenoceptor beta 1	Canis lupus familiaris	6-26
17756096-2	1977	As an example, an apparent oxygen utilization rate of 0.20 +/- 0.02 milliliter per liter of water per year has been obtained for the Subtropical Mode water (18 degrees C water) in the Sargasso Sea.	Oxygen	27-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	193-196
13260-5	1977	The change in the ODC of normolipemic diabetics is considered to be an expresssion of the presence of an increased proportion of a hemoglobin fraction (Hb Alc) with increased oxygen affinity.	Oxygen	175-181	allantoicase	Homo sapiens	155-158
331893-0	1977	Oxygen sensing heme proteins: monoxygenases, myoglobin and hemoglobin.	Oxygen	0-6	myoglobin	Homo sapiens	45-54
564045-1	1977	When the diffusion of oxygen is facilitated by myoglobin this diffusional transport can adequately supply oxygen required by tissue metabolism over greatly increased distances.	Oxygen	22-28	myoglobin	Homo sapiens	47-56
564045-1	1977	When the diffusion of oxygen is facilitated by myoglobin this diffusional transport can adequately supply oxygen required by tissue metabolism over greatly increased distances.	Oxygen	106-112	myoglobin	Homo sapiens	47-56
564045-2	1977	Earlier analyses of this phenomenon have considered the rate of reaction between oxygen and myoglobin as infinitely fast.	Oxygen	81-87	myoglobin	Homo sapiens	92-101
1016435-0	1976	[Alveolar arterial oxygen gradient in normal adults living at 2240 m. above sea level (author"s transl)].	Oxygen	19-25	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
960989-0	1976	[Adaptation of the oxygen electrode of the Astrup apparatus AME-1 for the measurement of oxygen consuming enzyme activities].	Oxygen	19-25	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	60-65
960989-0	1976	[Adaptation of the oxygen electrode of the Astrup apparatus AME-1 for the measurement of oxygen consuming enzyme activities].	Oxygen	89-95	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	60-65
134577-1	1976	In order to evaluate the distribution of molecular oxygen in biological systems, the oxygen solubility (ml/ml atm) at 37 degrees C in aqueous solutions of thirty organic substances with different concentrations was measured by the classical Van Slyke principle.	Oxygen	85-91	ATM serine/threonine kinase	Homo sapiens	110-113
1275087-2	1976	After 7 days of exposure to 90% O2 (1atm), superoxide dismutase activities in mitochondrial and cytosolic fractions increased, respectively, to 245 and 145% of control; glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities increased, respectively, to 317, 175, and 413% of control.	Oxygen	32-34	glutathione-disulfide reductase	Rattus norvegicus	193-214
1276159-1	1976	57Fe-enriched complexes of hemoglobin and myoglobin with CO and O2 were photodissociated at 4.2 degrees K, and the resulting spectra were compared with those of the deoxy forms.	Oxygen	64-66	myoglobin	Homo sapiens	42-51
788716-3	1976	Peripheral tissues, e.g. muscles and kidneys, have to depend on local stores of oxygen, i.e. myoglobin, or, when these are exhausted, on anaerobic metabolism.	Oxygen	80-86	myoglobin	Homo sapiens	93-102
1220689-9	1975	Results of experiments on cyanide inhibition of respiration and cytochrome oxidation support the suggestion that the susceptibility of cytochrome b to oxidation by molecular oxygen (reflected in its ability to react with CO) is probably irrelevant to the normal physiology of Pseudomonas AM1.	Oxygen	174-180	MEXAM1_RS00595	Methylobacterium extorquens AM1	135-147
124270-5	1975	Measurements of the reversal of ATP cleavage and binding by myosin suggest that oxygen exchanges result from reversible cleavage of ATP to ADP and Pi at the catalytic site and that the principal free energy change in ATP cleavage occurs in ATP binding.	Oxygen	80-86	myosin heavy chain 14	Homo sapiens	60-66
126449-0	1975	Oxygen exchange in the gamma-phosphoryl group of protein-bound ATP during Mg2+-dependent adenosine triphosphatase activity of myosin.	Oxygen	0-6	myosin heavy chain 14	Homo sapiens	126-132
126449-5	1975	A rapid equilibration between myosin-bound ATP and a myosin-products complex can account for the extra water oxygen incorporation of the product phosphate.	Oxygen	109-115	myosin heavy chain 14	Homo sapiens	30-36
126449-5	1975	A rapid equilibration between myosin-bound ATP and a myosin-products complex can account for the extra water oxygen incorporation of the product phosphate.	Oxygen	109-115	myosin heavy chain 14	Homo sapiens	53-59
126449-7	1975	Results presented in this paper show that protein-bound ATP labeled in the three terminal oxygen atoms of the gamma-phosphoryl group with 18O exchanges about 75% of its label within 2 s of binding to the active site of myosin.	Oxygen	90-96	myosin heavy chain 14	Homo sapiens	219-225
1162942-2	1975	In patients treated surgically without any preliminary pneumoencephalographic investigation the normo- and hypocapnic artificial ventilation of the lungs with a N2O and O2 mixture produced a significant drop of the CSF pressure.	Oxygen	169-171	colony stimulating factor 2	Homo sapiens	215-218
1130194-9	1975	The result of this study suggests the presence of an increased amount of haemoglobin fraction with high oxygen affinity (haemoglobin Alc) in the red cells of juvenile diabetics.	Oxygen	104-110	allantoicase	Homo sapiens	133-136
1055374-0	1975	Kinetics of oxygen and carbon monoxide binding to synthetic analogs of the myoglobin and hemoglobin active sites.	Oxygen	12-18	myoglobin	Homo sapiens	75-84
1055374-2	1975	The oxygen on and off rates and equilibria of these compounds can be made to closely match those of myoglobin, of hemoglobin alpha chains, or of the various steps for hemoglobin by varying solvent environment or the basicity of the proximal base.	Oxygen	4-10	myoglobin	Homo sapiens	100-109
10816439-0	2000	Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures.	Oxygen	114-120	insulin receptor	Rattus norvegicus	27-43
1121163-3	1975	Continuous exposure of mice to 8% O2 for 11 da resulted in a polycythemia of sufficient magnitude and duration to provide appropriate erythropoietic conditions for the erythropoietin assay.	Oxygen	34-36	erythropoietin	Mus musculus	168-182
6416690-5	1983	The rate constant for the oxygen addition to CCl3 radicals was determined by pulse radiolysis to 3.3 X 10(9) M-1 s-1.	Oxygen	26-32	C-C motif chemokine ligand 3	Homo sapiens	45-49
1054853-1	1975	Human serum dopamine-beta-hydroxylase [3,4-dihydroxyphenylethylamine, ascorbate: oxygen oxidoreducatse (beta-hydroxylating), EC 1.14.17.1] levels have been determined in 52 samples with a newly devised radioimmunoassay that utilizes purified human enzyme and its specific antiserum.	Oxygen	81-87	dopamine beta-hydroxylase	Homo sapiens	12-37
1105228-18	1975	The fact was confirmed that both hypocapnea and alkalosis produced the left-sised shift of oxygen dissociation curve, decrease in P50 (P02 at 50% saturation of oxygen), and in addition, narrowed arterio-mixed venous oxygen difference.	Oxygen	160-166	tumor protein, translationally-controlled 1	Homo sapiens	135-138
1105228-18	1975	The fact was confirmed that both hypocapnea and alkalosis produced the left-sised shift of oxygen dissociation curve, decrease in P50 (P02 at 50% saturation of oxygen), and in addition, narrowed arterio-mixed venous oxygen difference.	Oxygen	160-166	tumor protein, translationally-controlled 1	Homo sapiens	135-138
6311631-1	1983	Cyanide-promoted inactivation of the enzyme rhodanese [thiosulfate sulfurtransferase (EC 2.8.1.1)] in the presence of ketoaldehydes is caused by reduced forms of molecular oxygen generated during autoxidation of the reaction products.	Oxygen	172-178	thiosulfate sulfurtransferase	Homo sapiens	55-84
1191177-9	1975	R-2 reacts 16 times more readily that R-1 with oxygen under formation of single-strand breaks in the DNA.	Oxygen	47-53	CD1b molecule	Homo sapiens	38-41
6301555-7	1983	In the hexokinase system the control strength of the translocator on mitochondrial respiration was zero up to respiration rates of about 60 nmol O2/mg protein per min.	Oxygen	145-147	hexokinase	Saccharomyces cerevisiae S288C	7-17
10816439-3	2000	In hepatocyte cultures venous O(2) partial pressure (pO(2)) induced insulin receptor protein expression.	Oxygen	30-34	insulin receptor	Rattus norvegicus	68-84
10799910-8	2000	Although this therapy protected the vascular compartment, rabbits treated with anti-CD14 mAb had increased bacterial burdens in the bronchoalveolar lavage fluid recovered from the instilled lung (p = 0.005) and widened alveolar-arterial oxygen difference.	Oxygen	237-243	monocyte differentiation antigen CD14	Oryctolagus cuniculus	84-88
6847637-5	1983	An increase in the rate of O2 utilization but not glucose release was observed after the addition of phospholipase A2 to hepatocytes.	Oxygen	27-29	phospholipase A2 group IB	Rattus norvegicus	101-117
4836565-0	1974	Oxygen deficit and debt in submaximal exercise at sea level and high altitude.	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	50-53
10825135-12	2000	From this curve, the oxygen tensions of tumors exposed to EF3 under control conditions, during PDT, or after PDT were calculated to be 3.1-5.3, 1.2-2.4, and 3.0-5.2 mm Hg, respectively.	Oxygen	21-27	fumarate hydratase 1	Mus musculus	58-61
6605834-4	1983	Based on estimates of superoxide anion production there appears to be excess SOD protection in the rainbow trout retina, which could, at least in part, account for its resistance to oxygen toxicity.	Oxygen	182-188	Superoxide dismutase	Oncorhynchus mykiss	77-80
10825135-17	2000	Tissue oxygen tensions corresponding to EF3 binding levels can be calculated.	Oxygen	7-13	fumarate hydratase 1	Mus musculus	40-43
4805471-0	1973	A catheter tip transducer for continuous measurement of blood oxygen tension in neonates.	Oxygen	62-68	TOR signaling pathway regulator	Homo sapiens	11-14
10830714-1	2000	The platelet type 12 lipoxygenase (12-LOX) adds molecular oxygen to C-12 arachidonic acid to yield 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid.	Oxygen	24-30	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	35-41
6376215-4	1983	High oxygen concentration was beneficial for high release of IL-2 and MCF, whereas MIF and TRF were better produced at low oxygen concentrations.	Oxygen	5-11	interleukin 2	Mus musculus	61-73
6376215-4	1983	High oxygen concentration was beneficial for high release of IL-2 and MCF, whereas MIF and TRF were better produced at low oxygen concentrations.	Oxygen	123-129	interleukin 5	Mus musculus	91-94
4556354-0	1972	Oxygen sag and stream self-purification.	Oxygen	0-6	S-antigen visual arrestin	Homo sapiens	7-10
10766782-5	2000	An sod1/fet3 double mutant showed increased sensitivity to oxygen and increased transcription of FET4, an alternative, low affinity, iron transporter.	Oxygen	59-65	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	3-7
6576383-1	1983	Administration of Fluosol DA with oxygen elevated the tissue p02 in tumors primarily due to the increased local blood flow and to the higher oxygen content of Fluosol-DA.	Oxygen	34-40	tumor protein, translationally-controlled 1	Homo sapiens	61-64
4392239-2	1970	When a mixture of FMN and a reducing substrate (e.g. unprotonated amine) is illuminated oxygen is consumed.	Oxygen	88-94	formin 1	Homo sapiens	18-21
6576383-1	1983	Administration of Fluosol DA with oxygen elevated the tissue p02 in tumors primarily due to the increased local blood flow and to the higher oxygen content of Fluosol-DA.	Oxygen	141-147	tumor protein, translationally-controlled 1	Homo sapiens	61-64
10766782-5	2000	An sod1/fet3 double mutant showed increased sensitivity to oxygen and increased transcription of FET4, an alternative, low affinity, iron transporter.	Oxygen	59-65	ferroxidase FET3	Saccharomyces cerevisiae S288C	8-12
4392239-6	1970	The kinetics of type I reactions with EDTA, dl-alpha-phenylglycine and diethanolamine are all consistent with a mechanism in which the rate-determining step, hydrogen abstraction by the FMN triplet, is followed by rapid reoxidation of reduced FMN by oxygen.	Oxygen	250-256	formin 1	Homo sapiens	186-189
4392239-11	1970	Individual rate constants for quenching and reaction of the FMN triplet with substrate were calculated (2.4x10(8) and 2.1x10(7)m(-1)s(-1) respectively for EDTA) on the assumption that oxygen quenches the triplet in a diffusion-controlled reaction.	Oxygen	184-190	formin 1	Homo sapiens	60-63
10889449-3	2000	In the presence of the oxygen free radical spin trapping reagent, 5,5-dimethyl pyrroline-N-oxide (DMPO), the induction of MnSOD gene expression by TNF-alpha was significantly reduced.	Oxygen	23-29	superoxide dismutase 2	Homo sapiens	122-127
5472741-0	1970	[The effect of trinitrophenylation of myosin on the oxygen isotope exchange reaction in a myosin--ATP--H20-18 system].	Oxygen	52-58	myosin heavy chain 14	Homo sapiens	38-44
7150666-1	1982	Fe2+ is oxidized and taken up by ferritin or apoferritin in the presence of dioxygen.	Oxygen	76-84	ferritin heavy chain 1	Homo sapiens	45-56
5472741-0	1970	[The effect of trinitrophenylation of myosin on the oxygen isotope exchange reaction in a myosin--ATP--H20-18 system].	Oxygen	52-58	myosin heavy chain 14	Homo sapiens	90-96
7168096-0	1982	Acute oxygen toxicity in a saturation diver working in the North Sea.	Oxygen	6-12	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
10747809-0	2000	Mutation of serine 395 of tyrosine hydroxylase decouples oxygen-oxygen bond cleavage and tyrosine hydroxylation.	Oxygen	57-63	tyrosine hydroxylase	Rattus norvegicus	26-46
6293826-0	1982	Regulation of synthesis of catalases and iso-1-cytochrome c in Saccharomyces cerevisiae by glucose, oxygen and heme.	Oxygen	100-106	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	41-46
6053677-0	1967	Oxygen uptake in man during exhaustive work at sea level and high altitude.	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
10747809-0	2000	Mutation of serine 395 of tyrosine hydroxylase decouples oxygen-oxygen bond cleavage and tyrosine hydroxylation.	Oxygen	64-70	tyrosine hydroxylase	Rattus norvegicus	26-46
6293826-6	1982	Anaerobic and heme-deficient cells lack or have extremely low levels of iso-1-cytochrome c mRNA, which, like catalase mRNAs, is accumulated rapidly during oxygen adaptation.	Oxygen	155-161	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	72-77
10777648-0	2000	Electrochemical Oxidation of Water to Dioxygen Catalyzed by the Oxidized Form of the Bis(ruthenium - hydroxo) Complex in H(2)O This work was partly supported by the Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture of Japan (No.	Oxygen	38-46	activation induced cytidine deaminase	Homo sapiens	174-177
7122212-8	1982	But in view of the role of PK in the control of the 2,3-DPG level and thereby of the oxygen affinity of red blood cells, we assume that the physiological significance of the PK isozyme change is akin to that of the switch from fetal to adult hemoglobin in other species.	Oxygen	85-91	pyruvate kinase PKLR	Oryctolagus cuniculus	27-29
24271910-5	1982	Whereas ceruloplasmin produces a 4:1 ratio of Fe(II) oxidized to oxygen utilized, the non-enzymic components yield a 2:1 or 3.09:1 ratio.	Oxygen	65-71	ceruloplasmin	Homo sapiens	8-21
24271910-6	1982	These data support the role of ceruloplasmin as an antioxidant that prevents the formation of the intermediate active oxygen species O 2 (-)   and H2O 2 ( ) through the Fe(II) auto-oxidation reaction.A hitherto unrecognized factor in the control of nonenzymic oxidation of Fe(II) was serum albumin.	Oxygen	118-124	ceruloplasmin	Homo sapiens	31-44
7038471-1	1982	The extent of the oxygen effect for cell survival was studied in diploid and haploid wild-type yeast and in mutants belonging to the rad2, rad6 and rad50 epistatic group.	Oxygen	18-24	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	139-143
7038471-1	1982	The extent of the oxygen effect for cell survival was studied in diploid and haploid wild-type yeast and in mutants belonging to the rad2, rad6 and rad50 epistatic group.	Oxygen	18-24	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	148-153
7038471-2	1982	In haploids, reduced oxygen enhancement ratios were found in rad52, rad6 and rad18.	Oxygen	21-27	recombinase RAD52	Saccharomyces cerevisiae S288C	61-66
14158545-3	1964	The Bennett PR1 delivers more constant percentages of oxygen, in the range 61.5 to 72.3%.	Oxygen	54-60	transmembrane protein 37	Homo sapiens	12-15
11933306-1	2000	The use of heat in wound healing has been demonstrated to aid oxygen flow and hence healing in acute wounds.	Oxygen	62-68	activation induced cytidine deaminase	Homo sapiens	58-61
7038471-2	1982	In haploids, reduced oxygen enhancement ratios were found in rad52, rad6 and rad18.	Oxygen	21-27	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	68-72
7038471-4	1982	In diploids the oxygen effect was decreased in rad2, rad52 and rad18.	Oxygen	16-22	recombinase RAD52	Saccharomyces cerevisiae S288C	53-58
6275898-6	1982	The large excess of O2 uptake seen in polarographic assays with horse cytochrome c over that expected from spectrophotometric measurements was not apparent with the trifluoromethylphenylcarbamylated lysine-13 derivative.	Oxygen	20-22	cytochrome c, somatic	Equus caballus	70-82
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	164-170	superoxide dismutase [Cu-Zn]	Bos taurus	46-72
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	164-170	superoxide dismutase [Cu-Zn]	Bos taurus	74-83
6976501-0	1982	Corticotropin-releasing factor: effects on the sympathetic nervous system and oxygen consumption.	Oxygen	78-84	corticotropin releasing hormone	Homo sapiens	0-30
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	164-170	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	89-109
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	180-184	superoxide dismutase [Cu-Zn]	Bos taurus	46-72
7165152-0	1982	Myoglobin-facilitated oxygen transport in heterogeneous red muscle tissue.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	180-184	superoxide dismutase [Cu-Zn]	Bos taurus	74-83
10751725-9	2000	A lower catalytic activity of enzymes such as Cu/Zn superoxide dismutase (Cu/Zn-SOD) and cytochrome-c oxidase could increase the intracellular production of active oxygen species (O(2)(-), H(2)O(2) and OH(o)) with the consequent clastogenic effects.	Oxygen	180-184	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	89-109
10868965-6	2000	In the leptin-treated young rats, there was a 24% increase in oxygen consumption compared with the pair-fed rats, but there were no changes in oxygen consumption in the aged rats.	Oxygen	62-68	leptin	Rattus norvegicus	7-13
7260110-6	1981	Porphobilinogen-deaminase activity increased after the first day of hypoxia, reached a maximum at the 14-16th day and did not decrease to normal values until the 15th day after return to normal oxygen pressure.	Oxygen	194-200	hydroxymethylbilane synthase	Rattus norvegicus	0-25
10681576-4	2000	In vivo measurements of photochemical quenching and oxygen evolution show that impairment of the donor side of PSI in the PsaF mutants leads to a diminished linear electron transfer and/or a decrease of photosystem II (PSII) activity in high light.	Oxygen	52-58	uncharacterized protein	Chlamydomonas reinhardtii	122-126
6265441-8	1981	It is concluded that aerobic oxidation of exogenous NADH involves the following pathway: NADH leads to NADH-cytochrome b5 reductase leads to cytochrome b5 leads to intermembrane cytochrome c leads to cytochrome oxidase leads to oxygen.	Oxygen	228-234	cytochrome b5 type A	Homo sapiens	108-121
6265441-8	1981	It is concluded that aerobic oxidation of exogenous NADH involves the following pathway: NADH leads to NADH-cytochrome b5 reductase leads to cytochrome b5 leads to intermembrane cytochrome c leads to cytochrome oxidase leads to oxygen.	Oxygen	228-234	cytochrome b5 type A	Homo sapiens	141-154
10666377-5	2000	The increased survival of endothelial cells in transgenic mice in the face of oxygen-induced down-regulation of vascular endothelial growth factor was accompanied by an increase in astrocyte-derived fibroblast growth factor-2.	Oxygen	78-84	fibroblast growth factor 2	Mus musculus	199-225
6262312-1	1981	The reactions of horse heart cytochrome c with succinate-cytochrome c reductase and cytochrome oxidase were studied as a function of ionic strength using both spectrophotometric and oxygen electrode assay techniques.	Oxygen	182-188	cytochrome c, somatic	Equus caballus	29-41
7018748-2	1981	An increased rate of ethanol metabolism is linked to a greater oxygen demand, thus resulting in greater susceptibility to hypoxia in Zone 3 of the liver acinus, a factor which might be responsible for hepatocellular necrosis in alcoholic hepatitis.	Oxygen	63-69	apoptotic chromatin condensation inducer 1	Homo sapiens	153-159
7002921-1	1980	Evidence for two kinds of myosin-active site differing in their rate of intermediate oxygen exchange.	Oxygen	85-91	myosin heavy chain 14	Homo sapiens	26-32
7004657-1	1980	The myoglobin has the property to store the oxygen at the level of the striated muscle.	Oxygen	44-50	myoglobin	Homo sapiens	4-13
7463707-0	1980	[Serum myoglobin levels following administration of succinylcholine during nitrous oxide-oxygen-halothane anesthesia (author"s transl)].	Oxygen	89-95	myoglobin	Homo sapiens	7-16
6253450-3	1980	The modified cytochrome c bound to cytochrome c-depleted mitochondria with the same Kd as native cytochrome c and restored oxygen uptake to the same extent.	Oxygen	123-129	cytochrome c, somatic	Equus caballus	13-25
6253450-3	1980	The modified cytochrome c bound to cytochrome c-depleted mitochondria with the same Kd as native cytochrome c and restored oxygen uptake to the same extent.	Oxygen	123-129	cytochrome c, somatic	Equus caballus	35-47
6253450-3	1980	The modified cytochrome c bound to cytochrome c-depleted mitochondria with the same Kd as native cytochrome c and restored oxygen uptake to the same extent.	Oxygen	123-129	cytochrome c, somatic	Equus caballus	35-47
6774103-5	1980	It is postulated that elevated red cell 2,3 DPG lowers the hypoxic stimulus for erythropoietin production by enhancing oxygen unloading to the tissues, thus partially compensating for the anemia associated with total parenteral nutrition.	Oxygen	119-125	erythropoietin	Rattus norvegicus	80-94
6244857-6	1980	Space-filling models revealed the possibility of a hydrogen bond between the oxygen of amide of residue-70 asparagine and the epsilon-amino nitrogen of residue-72 lysine in unmethylated horse heart cytochrome C.	Oxygen	77-83	cytochrome c, somatic	Equus caballus	198-210
7295866-1	1980	The role of myoglobin in facilitated diffusion of oxygen in muscle in examined in a tissue model that utilizes a central supplying capillary and a tissue cylinder concentric with the central capillary, and that includes the nonlinear characteristics of the oxygen-hemoglobin dissociation reaction.	Oxygen	50-56	myoglobin	Homo sapiens	12-21
491972-2	1979	Fourteen hundred microliter O2 consumed/hr/g body weight at STP was used as a value, below which future obese rats could be identified among 18-day-old pups from fa/+ X fa/+ crosses.	Oxygen	28-30	thyroid hormone receptor interactor 10	Rattus norvegicus	60-63
572704-0	1979	Dioxygen replacement reaction in myoglobin.	Oxygen	0-8	myoglobin	Homo sapiens	33-42
572704-1	1979	The replacement reaction of myoglobin (Mb), MbCO + O2 leads to MbO2 + CO leads to MbCO + O2, has been studied with flash photolysis in the temperature range from 140 to 320 K and the time range from 2 mus to 200 s. In a fraction of the Mb, the photodissociated CO remains within the protein; rebinding is not affected by the presence of O2 and occurs with rates that are identical with the ones observed earlier in solvents containing only CO.	Oxygen	51-53	myoglobin	Homo sapiens	28-37
572704-1	1979	The replacement reaction of myoglobin (Mb), MbCO + O2 leads to MbO2 + CO leads to MbCO + O2, has been studied with flash photolysis in the temperature range from 140 to 320 K and the time range from 2 mus to 200 s. In a fraction of the Mb, the photodissociated CO remains within the protein; rebinding is not affected by the presence of O2 and occurs with rates that are identical with the ones observed earlier in solvents containing only CO.	Oxygen	65-67	myoglobin	Homo sapiens	28-37
572704-1	1979	The replacement reaction of myoglobin (Mb), MbCO + O2 leads to MbO2 + CO leads to MbCO + O2, has been studied with flash photolysis in the temperature range from 140 to 320 K and the time range from 2 mus to 200 s. In a fraction of the Mb, the photodissociated CO remains within the protein; rebinding is not affected by the presence of O2 and occurs with rates that are identical with the ones observed earlier in solvents containing only CO.	Oxygen	65-67	myoglobin	Homo sapiens	28-37
227369-4	1979	Cell yields with respect to succinate and O(2) were higher in wild-type than in the mutant lacking cytochrome c by an amount suggesting loss in the mutant of 30% of the ATP-generating capacity of wild-type bacteria.	Oxygen	42-46	MEXAM1_RS12150	Methylobacterium extorquens AM1	99-111
232945-8	1979	Thus, we can only speculate that under conditions where levels of ceruloplasmin are markedly elevated, as during pregnancy, during acute infections, or in association with inflammatory diseases (such as rheumatoid arthritis), this acute-phase reactant may play a major role as a circulating scavenger of oxygen-derived free radicals.	Oxygen	304-310	ceruloplasmin	Homo sapiens	66-79
568627-0	1978	Oxygen exchange by single-headed myosin.	Oxygen	0-6	myosin heavy chain 14	Homo sapiens	33-39
743282-0	1978	The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen.	Oxygen	200-206	serpin family B member 3	Homo sapiens	71-91
81106-3	1978	BLM-Cu2+ was found to stimulate considerably microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent oxygen consumption and malondialdehyde formation, whereas BLM inhibited both of the effects.	Oxygen	118-124	BLM RecQ like helicase	Rattus norvegicus	0-3
731456-0	1978	Carbon dioxide oxygen dissociation curves during and after a ski course at moderate altitude [proceedings].	Oxygen	15-21	SKI proto-oncogene	Homo sapiens	61-64
670189-0	1978	Characterization of phosphate oxygen exchange reactions catalyzed by myosin through measurement of the distribution of 18-O-labeled species.	Oxygen	30-36	myosin heavy chain 14	Homo sapiens	69-75
670189-1	1978	The change in the distribution of the phosphate species containing 0 to 4 18O oxygens per Pi was investigated during medium Pi equilibrium HOH exchange catalyzed by myosin subfragment 1.	Oxygen	78-85	myosin heavy chain 14	Homo sapiens	165-171
670189-5	1978	The intermediate exchange of Pi oxygens during hydrolysis of 18O-labeled ATP by myosin has also been investigated.	Oxygen	32-39	myosin heavy chain 14	Homo sapiens	80-86
689201-5	1978	The data obtained suggest that erythropoietin is formed in the cortex of the kidney and its production is controlled by the degree of oxygen supply of the kidney tissue.	Oxygen	134-140	erythropoietin	Rattus norvegicus	31-45
148301-11	1978	Partial deficiency of 2,3-DPGM should now be considered in the differential diagnosis of compensated hemolysis associated with increased oxygen affinity.	Oxygen	137-143	bisphosphoglycerate mutase	Homo sapiens	26-30
209807-6	1978	Drugs that stimulated oxygen utilization also stimuated intracellular (c " c1).	Oxygen	22-28	C-C motif chemokine ligand 14	Homo sapiens	71-77
641045-1	1978	The time course of oxygen-18 exchange between [18O]Pi and normal water, catalyzed by myosin subfragment 1 in the presence of MgADP, was followed using the shift in 31P NMR caused by the presence of oxygen-18 bound to the phosphorus.	Oxygen	198-204	myosin heavy chain 14	Homo sapiens	85-91
643379-5	1978	It is concluded that increases in the lung complement of SOD, GR, GP, and GSH in the neonatal rat during oxygen challenge may provide the mechanism(s) for their increased tolerance to hyperoxia-induced lung injury as compared to the adults.	Oxygen	105-111	glutathione-disulfide reductase	Rattus norvegicus	62-64
13949497-0	1963	Role of THAM in protecting mice against convulsive episodes caused by exposure to oxygen under high pressure.	Oxygen	82-88	dipeptidylpeptidase 4	Mus musculus	8-12
14464766-0	1962	Further evidence for oxygen exchange at an intermediate stage in myosin hydrolysis.	Oxygen	21-27	myosin heavy chain 14	Homo sapiens	65-71
13584010-0	1958	Studies on the oxygen and carbon monoxide equilibria of human myoglobin.	Oxygen	15-21	myoglobin	Homo sapiens	62-71
13527096-0	1957	[Method for calculation of molecular oxygen diffusion coefficient from measurement of oxygen diffusion in hemoglobin and myoglobin solutions].	Oxygen	37-43	myoglobin	Homo sapiens	121-130
13376137-0	1956	A method for the determination of the O18 concentration of the oxygen of organic compounds.	Oxygen	63-69	immunoglobulin kappa variable 1-33	Homo sapiens	38-41
18098543-0	1948	Isotopic analysis of the oxygen evolved by illuminated chloroplasts in normal water and in water enriched with O18.	Oxygen	25-31	immunoglobulin kappa variable 1-33	Homo sapiens	111-114
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	157-163	interleukin 1 alpha	Homo sapiens	87-95
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	204-210	interleukin 1 alpha	Homo sapiens	87-95
34000467-10	2021	Our findings provide new insights into the intersection of low oxygen, H. pylori, and inflammation and disclosed how H. pylori under low oxygen tension can aggravate IL-1beta secretion.	Oxygen	63-69	interleukin 1 alpha	Homo sapiens	166-174
34000467-10	2021	Our findings provide new insights into the intersection of low oxygen, H. pylori, and inflammation and disclosed how H. pylori under low oxygen tension can aggravate IL-1beta secretion.	Oxygen	137-143	interleukin 1 alpha	Homo sapiens	166-174
33834866-6	2021	Mechanistically, recombinant periostin caused over-activation of glycolysis and mitochondrial dysfunction in VSMCs, as assessed by extracellular acidification rate (ECAR), oxygen consumption rate, and mitochondrial respiratory chain complexes activities.	Oxygen	172-178	periostin	Homo sapiens	29-38
84346-7	1978	These results demonstrate that sufficient O2 supply is critical both for reabsorption of Na+ and for handling of PAH.	Oxygen	42-44	phenylalanine hydroxylase	Rattus norvegicus	113-116
903358-2	1977	The inhibition of bovine adrenal estrogen sulfotransferase has been studied utilizing representative androgens and estrogens with structural changes in rings A, B, and D. These investigations have shown oxygen functions in positions 3, 16, or 17 to be required for the binding of estrogens or androgens to the enzyme.	Oxygen	203-209	sulfotransferase family 1E member 1	Bos taurus	33-58
10771790-3	2000	Although intuitively it would seem that supplemental oxygen during sleep should be of medical benefit in COPD patients with NOD, studies to data have not substantiated this idea.	Oxygen	53-59	atrophin 1	Homo sapiens	124-127
907349-0	1977	The diffusion-controlled reaction kinetics of the binding of CO and O2 to myoglobin in glycerol-water mixtures of high viscosity.	Oxygen	68-70	myoglobin	Homo sapiens	74-83
70526-4	1977	IR spectroscopy indicated that the magnesium is bonded between the carbonyl at C-2 and the oxygen at C-4" (or vice versa).	Oxygen	91-97	complement C2	Homo sapiens	79-82
10689961-3	2000	It is also conceivable that 4 including a novel tetrasubstituted olefinic end group arises from epoxy carotenoids by the opening of the C-6-oxygen bond of the oxirane ring and the subsequent migration of the methyl group at the C-1 position (route b).	Oxygen	140-146	complement C6	Homo sapiens	136-139
70526-4	1977	IR spectroscopy indicated that the magnesium is bonded between the carbonyl at C-2 and the oxygen at C-4" (or vice versa).	Oxygen	91-97	complement C4A (Rodgers blood group)	Homo sapiens	101-104
856316-0	1977	The facilitated diffusion of oxygen by hemoglobin and myoglobin.	Oxygen	29-35	myoglobin	Homo sapiens	54-63
11272523-5	2000	The ethylene ligand of complexes TpMe2Rh(C2H4)(PR3) is labile, and several peroxo compounds of composition TpMe2Rh(O2)(PR3) have been isolated by their reaction with O2.	Oxygen	115-117	proteinase 3	Homo sapiens	119-122
856316-1	1977	We have clarified the use of Wyman"s differential equation for the facilitated oxygen flux through a slab of solution of myoglobin or hemoglobin by showing that there is a unique choice of boundary condition on the carrier concentration to be employed in conjunction with it.	Oxygen	79-85	myoglobin	Homo sapiens	121-130
11450086-4	2000	Subjection of animals to heat stress in a biological oxygen demand (BOD) incubator at 38 degrees C for 4 h resulted in a marked redistribution of CGRP immunoreactivity.	Oxygen	53-59	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
857966-3	1977	It is assumed that renin and erythropoietin could be regarded as two links of the same broad control system, responsible for optimum tissue oxygen supply.	Oxygen	140-146	erythropoietin	Rattus norvegicus	29-43
11237172-1	2000	Cyanidin 3-O-beta-D-glucoside (C3G) is included in anthocyanins, and expected to have a potency to scavenge active oxygen species in vivo.	Oxygen	115-121	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	31-34
193169-4	1977	However, opiates without the oxygen bridge as in the structure of morphine, such as levorphanol and the benzomorphans show affinities for the receptors of 3H-enkephalin equal or greater than their affinities for the receptors of 3H-opiates.	Oxygen	29-35	proenkephalin	Rattus norvegicus	158-168
11191053-6	2000	At low O2 tension, the stabilized and nuclear hypoxia inducible factor- 1alpha (HIF-1alpha) is directly phosphorylated by p42/p44 MAPKs, an action which enhances HIF-1-dependent transcriptional activition of VEGF.	Oxygen	7-9	erythrocyte membrane protein band 4.2	Mus musculus	122-125
856928-0	1977	Influence of oxygen tension on somatomedin activity in vitro.	Oxygen	13-19	insulin-like growth factor 1	Rattus norvegicus	31-42
856928-6	1977	Chondrocyte metabolic activity in the presence of somatomedin in vitro showed a graded response to alterations in the atmospheric oxygen, being greatest at low oxygen pressure, and almost completely inhibited at 95% oxygen.	Oxygen	130-136	insulin-like growth factor 1	Rattus norvegicus	50-61
856928-6	1977	Chondrocyte metabolic activity in the presence of somatomedin in vitro showed a graded response to alterations in the atmospheric oxygen, being greatest at low oxygen pressure, and almost completely inhibited at 95% oxygen.	Oxygen	160-166	insulin-like growth factor 1	Rattus norvegicus	50-61
856928-6	1977	Chondrocyte metabolic activity in the presence of somatomedin in vitro showed a graded response to alterations in the atmospheric oxygen, being greatest at low oxygen pressure, and almost completely inhibited at 95% oxygen.	Oxygen	160-166	insulin-like growth factor 1	Rattus norvegicus	50-61
137740-0	1977	Mechanism of oxygen exchange in actin-activated hydrolysis of adenosine triphosphate by myosin subfragment 1.	Oxygen	13-19	myosin heavy chain 14	Homo sapiens	88-94
11191053-6	2000	At low O2 tension, the stabilized and nuclear hypoxia inducible factor- 1alpha (HIF-1alpha) is directly phosphorylated by p42/p44 MAPKs, an action which enhances HIF-1-dependent transcriptional activition of VEGF.	Oxygen	7-9	mitogen-activated protein kinase 3	Mus musculus	126-129
137740-1	1977	The gamma-phosphoryl groups of two intermediates (M-ATP and M-ADP-P1) in the pathway of MgATP hydrolysis by myosin undergo extensive oxygen exchange with water.	Oxygen	133-139	myosin heavy chain 14	Homo sapiens	108-114
10842752-6	2000	So far, HO-2 appears to be beneficial in oxygen toxicity in vivo, but the consequences of HO-2 overexpression have not yet been tested.	Oxygen	41-47	heme oxygenase 2	Homo sapiens	8-12
137740-7	1977	The higher value is about 18 times smaller than the rate constant, 5-3, for the reverse cleavage step of the myosin pathway, which is postulated to be responsible for oxygen exchange.	Oxygen	167-173	myosin heavy chain 14	Homo sapiens	109-115
137740-9	1977	The finding that kc differs for the four oxygens in each phosphate group is related to past observations on myosin-catalyzed oxygen exchange.	Oxygen	41-48	myosin heavy chain 14	Homo sapiens	108-114
137740-9	1977	The finding that kc differs for the four oxygens in each phosphate group is related to past observations on myosin-catalyzed oxygen exchange.	Oxygen	41-47	myosin heavy chain 14	Homo sapiens	108-114
10723673-4	2000	Hyperbaric oxygen mediates the effects of ATPI through four mechanisms: hyperoxygenation, vasoconstriction, reperfusion, and host factors.	Oxygen	11-17	ATP synthase inhibitory factor subunit 1	Homo sapiens	42-46
825533-5	1976	During oxygen exposure, catalase activity in PMN and AM decreased to 60% of its original activity, and gluthathione peroxidase was reduced in PMN to 60% and in AM to 20% of control values.	Oxygen	7-13	catalase	Cavia porcellus	24-32
790446-0	1976	Superoxide lon as the cause of the oxygen effect.	Oxygen	35-41	lon peptidase 1, mitochondrial	Homo sapiens	11-14
965296-0	1976	Effects of intermittent hyperbaric oxygen on guinea pig lung elastin and collagen.	Oxygen	35-41	elastin	Cavia porcellus	61-68
10567925-7	2000	Atmospheric O(2) inhibited the synthesis of a major basement membrane protein (Type IV collagen), a major surface protein (PECAM-1), and increased the synthesis of von Willebrand factor (vWf).	Oxygen	12-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	123-130
816344-6	1976	Allele frequency shifts to 6-phosphogluconate dehydrogenase and phosphoglucomutase were observed in 5% oxygen, and a shift of alpha-glycerophosphate dehydrogenase allele frequencies occurred in 60% oxygen.	Oxygen	103-109	Phosphogluconate dehydrogenase	Drosophila melanogaster	27-59
10604966-1	2000	Xanthine oxidoreductase (XOR) is a mammalian enzyme that possesses a series of redox centers, which use either NAD(+) or molecular oxygen for oxidation of the purines xanthine and hypoxanthine to uric acid.	Oxygen	131-137	xanthine dehydrogenase	Homo sapiens	0-23
10604966-1	2000	Xanthine oxidoreductase (XOR) is a mammalian enzyme that possesses a series of redox centers, which use either NAD(+) or molecular oxygen for oxidation of the purines xanthine and hypoxanthine to uric acid.	Oxygen	131-137	xanthine dehydrogenase	Homo sapiens	25-28
7559-6	1976	Furthermore, the temporary cessation of alpha-NADH-dependent oxygen consumption caused by ferricyanide and the corresponding oxidation-reduction of reduced cytochrome b5 were followed in the presence of ADP.	Oxygen	61-67	cytochrome b5 type A	Homo sapiens	156-169
33316086-2	2021	Hepcidin assures the balance of circulating and stored iron levels for multiple physiological processes including oxygen transport and erythropoiesis, while limiting the toxicity of excess iron.	Oxygen	114-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
10728868-1	2000	Temporally and spatially resolved absorption spectrometry has been used to study molecular LaO absorption in laser ablated plume from an La2O3 target The absorption time-of-flight (TOF) spectra of ground-state LaO molecules were measured The TOF spectra indicate that only one component is observed in vacuum and in an Ar ambient, while there are two component, a fast and a broad slow component, observed at higher O2 pressure.	Oxygen	416-418	interleukin 4 induced 1	Homo sapiens	210-213
33979025-6	2021	Accordingly, IL-1beta stimulation also increased oxygen consumption rate, but without a concomitant rise in fatty acid oxidation.	Oxygen	49-55	interleukin 1 alpha	Homo sapiens	13-21
33979025-7	2021	Together, this suggests that the IL-1beta-stimulated energy shift is driven by shunting of glucose-derived pyruvate into mitochondria to maintain elevated oxygen consumption in HUVECs.	Oxygen	155-161	interleukin 1 alpha	Homo sapiens	33-41
7559-8	1976	The results indicate that the oxygen consumption with alpha-NADH is due to electron transfer from alpha-NADH via NADH-cytochrome b5 reductase and cytochrome b5, in which the rate-determining step lies at some reaction after the reduction of cytochrome b5.	Oxygen	30-36	cytochrome b5 type A	Homo sapiens	118-131
7559-8	1976	The results indicate that the oxygen consumption with alpha-NADH is due to electron transfer from alpha-NADH via NADH-cytochrome b5 reductase and cytochrome b5, in which the rate-determining step lies at some reaction after the reduction of cytochrome b5.	Oxygen	30-36	cytochrome b5 type A	Homo sapiens	146-159
7559-8	1976	The results indicate that the oxygen consumption with alpha-NADH is due to electron transfer from alpha-NADH via NADH-cytochrome b5 reductase and cytochrome b5, in which the rate-determining step lies at some reaction after the reduction of cytochrome b5.	Oxygen	30-36	cytochrome b5 type A	Homo sapiens	146-159
10491133-16	1999	The data are consistent with the possibility that NO interaction with HO-2-bound heme effects electronic interactions of residues involved in substrate binding and/or oxygen activation.	Oxygen	167-173	heme oxygenase 2	Homo sapiens	70-74
183873-3	1976	The hydroxylation of phenytoin that was decreased at low level of cytochrome P 450 and oxygen, reached again a normal level after induction of cytochrome P 450 in spite of the persistency of a low level of available oxygen.	Oxygen	216-222	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	143-159
33601106-0	2021	Synergistically coupling of Fe-doped CoP nanocubes with CoP nanosheet arrays towards enhanced and robust oxygen evolution electrocatalysis.	Oxygen	105-111	caspase recruitment domain family member 16	Homo sapiens	37-40
33601106-0	2021	Synergistically coupling of Fe-doped CoP nanocubes with CoP nanosheet arrays towards enhanced and robust oxygen evolution electrocatalysis.	Oxygen	105-111	caspase recruitment domain family member 16	Homo sapiens	56-59
1194276-0	1975	Role of myoglobin in the oxygen supply to red skeletal muscle.	Oxygen	25-31	myoglobin	Homo sapiens	8-17
10499287-1	1999	The ability of myoglobin (Mb) to reversibly bind O2 and other ligands has been well characterized.	Oxygen	49-51	myoglobin	Physeter catodon	15-24
1194276-3	1975	The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce.	Oxygen	4-10	myoglobin	Homo sapiens	31-40
1194276-3	1975	The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce.	Oxygen	4-10	myoglobin	Homo sapiens	150-159
1194276-3	1975	The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce.	Oxygen	4-10	myoglobin	Homo sapiens	150-159
1194276-6	1975	At lower oxygen pressure, where oxygen uptake is one-half maximal, the steady state oxygen consumption is roughly halved by abolishing functional myoglobin.	Oxygen	9-15	myoglobin	Homo sapiens	146-155
1194276-6	1975	At lower oxygen pressure, where oxygen uptake is one-half maximal, the steady state oxygen consumption is roughly halved by abolishing functional myoglobin.	Oxygen	32-38	myoglobin	Homo sapiens	146-155
1194276-6	1975	At lower oxygen pressure, where oxygen uptake is one-half maximal, the steady state oxygen consumption is roughly halved by abolishing functional myoglobin.	Oxygen	32-38	myoglobin	Homo sapiens	146-155
1194276-8	1975	We conclude from these experiments that myoglobin may transport a significant fraction of the oxygen consumed by muscle mitochondria.	Oxygen	94-100	myoglobin	Homo sapiens	40-49
34052625-4	2021	Here, we demonstrate that severe hypoxia (1% O2) upregulates CD44 expression via activation of hypoxia-inducible factor (HIF-1alpha), inducing GSCs to assume a highly invasive tumor.	Oxygen	45-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-131
34052625-5	2021	In contrast, moderate hypoxia (5% O2) upregulates osteopontin expression via activation of HIF-2alpha.	Oxygen	34-36	endothelial PAS domain protein 1	Mus musculus	91-101
34039370-11	2021	Fluorescence staining showed that HIF-1alpha expression was decreased, suggesting that the accumulation of MnO2 in the tumor caused the decomposition of H2O2 into O2 and alleviated the hypoxia of the tumor.	Oxygen	109-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-44
33988188-0	2021	Development of temperature dependent oxygen releasable nanofilm by modulating oxidation state of myoglobin.	Oxygen	37-43	myoglobin	Homo sapiens	97-106
33988188-1	2021	Controlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation.	Oxygen	22-28	myoglobin	Homo sapiens	34-43
34029065-1	2021	On reacting laser-ablated manganese or iron difluorides with O2 or O3 during codeposition in solid neon or argon, infrared absorptions of several new metal oxo-fluoride molecules, including OMF2, (eta1-O2)MF2, (eta2-O3)MF2, (eta1-O2)2MF2 (M = Mn and Fe), and O2MnF, have been observed.	Oxygen	61-63	secreted phosphoprotein 1	Homo sapiens	197-201
1175404-0	1975	Long-term results of continuous oxygen therapy at sea level.	Oxygen	32-38	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	50-53
1099250-0	1975	Oxygen sag and stream purification.	Oxygen	0-6	S-antigen visual arrestin	Homo sapiens	7-10
10398599-3	1999	The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization.	Oxygen	87-93	serpin family F member 1	Homo sapiens	25-29
4841058-0	1974	Kinetic activation volumes of the binding of oxygen and carbon monoxide to hemoglobin and myoglobin studied on a high-pressure laser flash photolysis apparatus.	Oxygen	45-51	myoglobin	Homo sapiens	90-99
34031767-11	2021	Expressions of BNIP3, ENO1, GAPDH, and SLC2A1, were upregulated in 7% oxygen/low glucose, compared to 20% oxygen groups.	Oxygen	70-76	enolase 1	Bos taurus	22-26
34027895-2	2021	Oxygen tension is an environmental cue that distinguishes peripheral tissues from the circulation, and here, we demonstrate that differentiation of human CD8+ T cells in the presence of hypoxia and TGF-beta1 led to the development of a TRM phenotype, characterized by a greater than 5-fold increase in CD69+CD103+ cells expressing human TRM hallmarks and enrichment for endogenous human TRM gene signatures, including increased adhesion molecule expression and decreased expression of genes involved in recirculation.	Oxygen	0-6	integrin subunit alpha E	Homo sapiens	307-312
4831065-0	1974	Infrared evidence for the mode of binding of oxygen to iron of myoglobin from heart muscle.	Oxygen	45-51	myoglobin	Homo sapiens	63-72
10405206-5	1999	IgG fractions from anti-PR3-positive patients induced more oxygen radical release from tumor necrosis factor-alpha-primed neutrophils compared with IgG fractions from anti-MPO-positive patients, as assessed by ferricytochrome c reduction (P &lt; 0.05) and dihydrorhodamine 123 oxidation (P &lt; 0.01).	Oxygen	59-65	proteinase 3	Homo sapiens	24-27
4858791-0	1974	Influence of CSF calcium concentration on the ventilatory response to CO2 and O2.	Oxygen	71-73	colony stimulating factor 2	Homo sapiens	13-16
34018522-0	2021	Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation.	Oxygen	113-119	NLR family, pyrin domain containing 3	Mus musculus	138-143
10381758-15	1999	ml-1) increased the beta1-adrenergic receptor-mediated hemodynamic parameters such as heart rate, stroke volume index, cardiac index, and oxygen delivery index (p &lt;.05).	Oxygen	138-144	adrenoceptor beta 1	Homo sapiens	20-45
33949507-5	2021	The contact time required for vibrational relaxation to take place is tau >= 150 fs for non-reacting and tau >= 330 fs for reacting (oxygen atom exchange) trajectories and the two processes are shown to probe different parts of the global potential energy surface.	Oxygen	133-139	microtubule associated protein tau	Homo sapiens	70-73
33949507-5	2021	The contact time required for vibrational relaxation to take place is tau >= 150 fs for non-reacting and tau >= 330 fs for reacting (oxygen atom exchange) trajectories and the two processes are shown to probe different parts of the global potential energy surface.	Oxygen	133-139	microtubule associated protein tau	Homo sapiens	105-108
5079218-0	1972	Factors influencing facilitated diffusion of oxygen in the presence of hemoglobin and myoglobin.	Oxygen	45-51	myoglobin	Homo sapiens	86-95
10385683-9	1999	Thus, in hepatocyte cultures, an O2 gradient in conjunction with EGF mimicked the perivenous induction by PB of the CYP2B1 gene observed in the liver in vivo.	Oxygen	33-35	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	116-122
5083406-0	1972	Facilitated diffusion of oxygen in the presence of hemoglobin and myoglobin.	Oxygen	25-31	myoglobin	Homo sapiens	66-75
5097602-6	1971	The mean minimum rates of oxygen consumption (ml./kg.min) were 31.0 for the albino and 38.8 for the hairless mouse; the corresponding estimated critical temperatures were in the ranges 30-32 degrees C for the albino mouse and 32-34 degrees C for the hairless mouse.4.	Oxygen	26-32	lysine demethylase and nuclear receptor corepressor	Mus musculus	100-108
34001853-7	2021	Functionally, ROS accumulation in CLL cells activated the AXL survival axis while upregulated SIRT3, suggesting that CLL cells rapidly remove highly reactive O2- to avoid its cytotoxic effect but maintain increased H2O2-level to promote cell survival.	Oxygen	158-161	AXL receptor tyrosine kinase	Homo sapiens	58-61
10360950-4	1999	Replacements of Asp-373 with Ala, Glu, Asn, and Gln resulted in changes in sodium affinity and cation selectivity in NaDC-1, indicating that the carbonyl oxygen at this position may play a role in the topological organization of the cation-binding site.	Oxygen	154-160	solute carrier family 13 member 2L homeolog	Xenopus laevis	117-123
34015314-6	2021	Through loss-of-function experiments, we demonstrated that SMYD2 knockdown or inhibition induced a metabolic shift from aerobic glycolysis to oxidative phosphorylation, as evidenced by glucose uptake, lactate production, extracellular acidification, and the oxygen consumption rate.	Oxygen	258-264	SET and MYND domain containing 2	Homo sapiens	59-64
33902285-6	2021	Mechanistically, 31 suppressed angiopoietin-2 (ANGPT2) expression induced by high glucose in retinal cells and exhibited in vivo antiangiogenic activity in choroidal neovascularization and oxygen-induced retinopathy mouse models.	Oxygen	189-195	angiopoietin 2	Mus musculus	31-45
5095970-0	1971	[Effect of p-nitrothiophenylation of myosin on the isotopic exchange reaction of oxygen in the system myosin-ATP-H2018].	Oxygen	81-87	myosin heavy chain 14	Homo sapiens	37-43
5095970-0	1971	[Effect of p-nitrothiophenylation of myosin on the isotopic exchange reaction of oxygen in the system myosin-ATP-H2018].	Oxygen	81-87	myosin heavy chain 14	Homo sapiens	102-108
4397269-0	1971	On the molecular mechanism of facilitated oxygen diffusion by haemoglobin and myoglobin.	Oxygen	42-48	myoglobin	Homo sapiens	78-87
10362714-2	1999	Nuclear factor (NF)-kappaB is thought to regulate the expression of endotoxin [lipopolysaccharide (LPS)]-induced inflammatory cytokines such as TNF, and NF-kappaB may also be influenced by changes in O2 tension.	Oxygen	200-202	tumor necrosis factor-like	Rattus norvegicus	144-147
5289931-0	1971	Synthesis of an actinomycin analog with substituted lactone oxygens (1",1"-bis(L-,-diaminopropionic acid))-actinomycin C (C 1).	Oxygen	60-67	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	122-125
4922928-0	1970	Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
4922928-0	1970	Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.	Oxygen	61-67	myoglobin	Homo sapiens	0-9
4922928-0	1970	Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.	Oxygen	61-67	myoglobin	Homo sapiens	48-57
33983027-4	2021	Oxygen-18 labeling experiments with either 18O-labeled 1 or 18O-labeled H2O2 are consistent with a sulfide oxygenation pathway that uses a eta1-Mo(OOH) hydroxoperoxyl species (3).	Oxygen	0-6	secreted phosphoprotein 1	Homo sapiens	139-143
33984278-6	2021	Furthermore, we show that activation of ZAR1 in the plant cell led to Glu11-dependent Ca2+ influx, perturbation of subcellular structures, production of reactive oxygen species, and cell death.	Oxygen	162-168	zygote arrest 1 S homeolog	Xenopus laevis	40-44
33682282-9	2021	We show that the N-doped carbon material derived from ZIF-EC1 is a promising electrocatalysis for oxygen reduction reaction (ORR).	Oxygen	98-104	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	58-61
10362714-3	1999	It is thus proposed that acute changes in O2 tension surrounding AMs alter NF-kappaB activation and TNF secretion in these lung cells.	Oxygen	42-44	tumor necrosis factor-like	Rattus norvegicus	100-103
5499798-7	1970	The corresponding P(CO2) gradients were about one quarter of those for oxygen in both species.5.	Oxygen	71-77	complement C2	Homo sapiens	18-23
10329706-13	1999	The signaling cascade preceding Elk-1 activation in response to oxygen deprivation was traced to activation of protein kinase C-betaII, Raf, mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase and mitogen-activated protein kinases.	Oxygen	64-70	zinc fingers and homeoboxes 2	Homo sapiens	136-139
4914103-0	1970	Oxygen sag and stream self-purification.	Oxygen	0-6	S-antigen visual arrestin	Homo sapiens	7-10
4229573-0	1967	[Oxygen isotope exchange between H2O18 and inorganic phosphate in the presence of actomyosin and myosin].	Oxygen	1-7	myosin heavy chain 14	Homo sapiens	86-92
33823141-5	2021	Mechanistically, exposure of senescent cells to low-oxygen conditions leads to AMPK activation and AMPK-mediated suppression of the mTOR-NF-kappaB signaling loop.	Oxygen	52-58	mechanistic target of rapamycin kinase	Mus musculus	132-136
33951271-6	2021	Increasing neuronal PITRM1 activity/expression re-established mitochondrial respiration, suppressed reactive oxygen species, improved synaptic function, and reduced loss of synapses even at advanced ages (up to 19-24 months).	Oxygen	109-115	pitrilysin metallepetidase 1	Mus musculus	20-26
10353251-0	1999	The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.	Oxygen	72-78	von Hippel-Lindau tumor suppressor	Homo sapiens	30-33
33838472-6	2021	In summary, our work highlights the critical involvement of O2--dependent peroxynitrite production in inhibiting PP2A-mediated dephosphorylation of IKK, thereby facilitating cancers to acquire an invasive phenotype.	Oxygen	60-62	protein phosphatase 2 phosphatase activator	Homo sapiens	113-117
33838472-7	2021	Given that NF-kappaB is a key player of chronic inflammation and carcinogenesis, our work unravels a novel synergistic node involving O2--driven redox milieu and deregulated PP2A as a potential therapeutic target.	Oxygen	134-136	protein phosphatase 2 phosphatase activator	Homo sapiens	174-178
17807292-2	1966	Deuterium and oxygen-18 measurements show that the Red Sea and Salton Sea brines are the results of a single process, the leaching of sediments by surface water circulating downward to a geothermal reservoir.	Oxygen	14-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
10353251-6	1999	Re-expression of pVHL restored oxygen-dependent instability.	Oxygen	31-37	von Hippel-Lindau tumor suppressor	Homo sapiens	17-21
17807292-2	1966	Deuterium and oxygen-18 measurements show that the Red Sea and Salton Sea brines are the results of a single process, the leaching of sediments by surface water circulating downward to a geothermal reservoir.	Oxygen	14-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	70-73
10353251-11	1999	The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing.	Oxygen	75-81	von Hippel-Lindau tumor suppressor	Homo sapiens	4-8
10320748-4	1999	In the wild-type, expression of the heat shock protein genes, hsp16-1 and hsp16-48, increased dramatically after incubation under high oxygen.	Oxygen	135-141	Heat shock protein Hsp-16.1/Hsp-16.11	Caenorhabditis elegans	62-69
5859926-0	1965	Myoglobin-facilitated diffusion of oxygen.	Oxygen	35-41	myoglobin	Homo sapiens	0-9
33946313-6	2021	The internalization and subsequent degradation of GluA2 AMPAR subunits following oxygen-glucose deprivation/reperfusion (OGD/R) is, at least in part, mediated by protein-interacting with C kinase-1 (PICK1).	Oxygen	81-87	protein interacting with PRKCA 1	Homo sapiens	162-197
10320748-4	1999	In the wild-type, expression of the heat shock protein genes, hsp16-1 and hsp16-48, increased dramatically after incubation under high oxygen.	Oxygen	135-141	Heat shock protein Hsp-16.48/Hsp-16.49	Caenorhabditis elegans	74-82
33925659-0	2021	DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.	Oxygen	13-19	DNA methyltransferase 3 beta	Homo sapiens	0-6
10200221-10	1999	Moreover, neurons of ages P14 or P21 showed a partial or complete recovery after reintroduction of oxygen and glucose, unlike mature neurons.	Oxygen	99-105	SUB1 regulator of transcription	Rattus norvegicus	26-29
33925659-9	2021	Together, these data have demonstrated, for the first time, that global 5mC, 5hmC, and DNMT3B are oxygen-sensitive in hMSCs.	Oxygen	98-104	DNA methyltransferase 3 beta	Homo sapiens	87-93
14339544-0	1965	[ACTIVITY OF GLUTATHIONE REDUCTASE IN THE BLOOD OF RATS UNDER NORMAL CONDITIONS AND IN OXYGEN DEFICIENCY].	Oxygen	87-93	glutathione-disulfide reductase	Rattus norvegicus	13-34
10385036-2	1999	Evidence exists for the participation of hydrogen peroxide-dependent regulation of prostaglandin production and soluble guanylate cyclase activity, resulting from the metabolism of peroxide by cyclooxygenase and catalase, respectively, in P(O2)-elicited signalling mechanisms that regulate vascular force generation.	Oxygen	241-243	catalase	Bos taurus	212-220
13981677-0	1963	An analog computer for oxygen sag calculations.	Oxygen	23-29	S-antigen visual arrestin	Homo sapiens	30-33
33995634-2	2021	PKM2 expression can reinforce the utilization of oxygen and synthesis of growth substances in cancer cells by enhancing OXPHOS and the Warburg effect.	Oxygen	49-55	pyruvate kinase M1/2	Homo sapiens	0-4
9933021-2	1999	Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --&gt; decreased blood flow --&gt; O2 and glucose deficit --&gt; decreased O2-requiring synthesis of DHEA --&gt; eventual decrease in number of DHEA-synthesizing cells.	Oxygen	10-12	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	144-151
33948575-2	2021	Kosti et al.1 demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.	Oxygen	123-129	CXADR pseudogene 1	Homo sapiens	85-88
34041450-5	2021	Further study showed Nrf2 regulated reactive-oxygen-species-mediated Hippo-yes-associated protein (YAP) signaling, which in turn modulated the NLRP3 inflammasome activation.	Oxygen	45-51	NLR family, pyrin domain containing 3	Mus musculus	143-148
33385726-5	2021	After aging, the abundance of oxygen-containing functional groups on the biochar surface, and the pH and organic carbon content of the biochar-treated soils significantly increased, thereby improving the sorption capacity for Cd2+ and Zn2+.	Oxygen	30-36	CD2 molecule	Sus scrofa	226-229
33877179-7	2021	These data explain why landmark, structurally characterized, mu2-eta1,eta2-peroxide and eta1-superoxide Co(salen)-O2 adducts were predominantly isolated from solvents with high C-H pKa values (DMSO, DMF, DMA).	Oxygen	114-116	secreted phosphoprotein 1	Homo sapiens	88-92
33702482-0	1914	Gas-Oxygen Anesthesia.	Oxygen	4-10	gastrin	Homo sapiens	0-3
33957299-10	2021	With O2-supplementation patients exhibited higher BRS and sample-entropy throughout the protocol (p < 0.05) vs. medical air, and improved the blunted RMSSD, SD1 responses during exercise (p = 0.024).	Oxygen	5-7	CUP2Q35	Homo sapiens	157-160
33744543-0	2021	Stable CuO with variable valence states cooperated with active Co2+ as catalyst/co-catalyst for oxygen reduction/methanol oxidation reactions.	Oxygen	96-102	complement C2	Homo sapiens	63-66
33744543-1	2021	Catalysts/co-catalysts for cathodic oxygen reduction and anodic methanol oxidation reactions (ORR/MOR) play the major roles in promoting the commercialization of direct methanol fuel cells.	Oxygen	36-42	opioid receptor mu 1	Homo sapiens	98-101
9933021-2	1999	Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --&gt; decreased blood flow --&gt; O2 and glucose deficit --&gt; decreased O2-requiring synthesis of DHEA --&gt; eventual decrease in number of DHEA-synthesizing cells.	Oxygen	281-283	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	144-151
33307067-5	2021	Acute myocardial infarction (AMI) induces local and systemic inflammation and reactive oxygen species generation, resulting in increased PCSK9 expression in hepatocytes and cardiomyocytes.	Oxygen	87-93	proprotein convertase subtilisin/kexin type 9	Homo sapiens	137-142
33918764-9	2021	The dynamic changes of blood perfusion, microvessel density, neovascularization activity, and oxygen metabolism showed a close physiological interplay in the one-year period prior to radiological recurrence of IDH-mutated AG.	Oxygen	94-100	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	210-213
9933021-2	1999	Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of the adrenal cortex, in which it is suggested that arteriosclerosis --&gt; decreased blood flow --&gt; O2 and glucose deficit --&gt; decreased O2-requiring synthesis of DHEA --&gt; eventual decrease in number of DHEA-synthesizing cells.	Oxygen	281-283	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	144-151
10024026-4	1999	The substrate-binding channel identified in CYP4A11 was found to have a much more sterically restricted active site than that in CYP102 that could cause limited access of long-chain fatty acid to the ferryl oxygen leading to the preferred omega-hydroxylation.	Oxygen	207-213	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-51
33827851-7	2021	Multicentre randomised controlled trial of side-lying compared with back-lying sleep positioning in reducing oxygen desaturation resulting from OSA in infants with CP at one month of age.	Oxygen	109-115	ceruloplasmin	Homo sapiens	164-166
33727052-4	2021	In the present study we investigated a new therapeutic approach by exploring the potential role of a specific microRNA, miR-126, in regulating VEGFA expression and retinal neovascularization in a rat oxygen-induced retinopathy (OIR) model.	Oxygen	200-206	microRNA 126b	Rattus norvegicus	110-127
33727052-4	2021	In the present study we investigated a new therapeutic approach by exploring the potential role of a specific microRNA, miR-126, in regulating VEGFA expression and retinal neovascularization in a rat oxygen-induced retinopathy (OIR) model.	Oxygen	200-206	vascular endothelial growth factor A	Rattus norvegicus	143-148
10024026-6	1999	Specifically, in the CYP4A11-lauric acid simulations, the omega hydrogens were closest to the ferryl oxygen most of the time.	Oxygen	101-107	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-28
33647387-0	2021	Blue light induces the nuclear translocation of neuropeptide receptor PAC1-R associated with the up-regulation of PAC1-R its own in reactive oxygen species associated way.	Oxygen	141-147	ADCYAP receptor type I	Homo sapiens	70-76
33647387-0	2021	Blue light induces the nuclear translocation of neuropeptide receptor PAC1-R associated with the up-regulation of PAC1-R its own in reactive oxygen species associated way.	Oxygen	141-147	ADCYAP receptor type I	Homo sapiens	114-120
33838143-9	2021	Genes in Clusters 1 and 4 were associated with glycolysis and energy production, showed higher activity at night (from ZT16 to ZT20), and were enriched in the Hif-1alpha signaling pathway and low-oxygen-related terms.	Oxygen	196-202	hypoxia inducible factor 1, alpha subunit	Mus musculus	159-169
9882635-1	1999	Although myoglobin (Mb) is considered to contribute significantly to the oxygen and diving capacity of marine mammals, few data are available for cetaceans.	Oxygen	73-79	myoglobin	Bos taurus	9-18
33482573-2	2021	Spectral shifts in the characteristic nuC=O region of acetone, as well as in the fingerprint regions, are unambiguously assigned to the formation of halogen bond involving one of the halogen atoms on CBr4/CCl4 as donor, and the carbonyl oxygen of acetone as acceptor.	Oxygen	237-243	carbonyl reductase 4	Homo sapiens	200-204
33482573-2	2021	Spectral shifts in the characteristic nuC=O region of acetone, as well as in the fingerprint regions, are unambiguously assigned to the formation of halogen bond involving one of the halogen atoms on CBr4/CCl4 as donor, and the carbonyl oxygen of acetone as acceptor.	Oxygen	237-243	C-C motif chemokine ligand 4	Homo sapiens	205-209
33850529-10	2021	Compared with the sham group, the reactive oxygen species activity and malondialdehyde content in the brain tissue of DJ-1 overexpressing 5XFAD mice were significantly decreased, while the superoxide dismutase activity was significantly increased (P<0.05).	Oxygen	43-49	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	118-122
9874807-7	1999	In addition, introduction of an oxygen on the sterol B-ring results in a ligand with LXRalpha-subtype selectivity.	Oxygen	32-38	nuclear receptor subfamily 1 group H member 3	Homo sapiens	85-93
33846783-7	2021	Furthermore, expression of Phgdh effectively increased expression levels of the cellular antioxidant enzymes catalase and superoxide dismutase 1, and decreased the levels of reactive oxygen species in chondrocytes; and this may have been regulated by a Kelch like ECH associated protein 1/nuclear factor erythroid 2-related factor 2 axis.	Oxygen	183-189	phosphoglycerate dehydrogenase	Rattus norvegicus	27-32
33421896-4	2021	Immobilisation of the CYP2C9-FLD, CYP2C9*2-FLD and CYP2C9*3-FLD on DDAB modified glassy carbon electrodes showed well defined redox couples on the oxygen-free cyclic voltammograms and mid-point potentials of all enzymes were calculated.	Oxygen	147-153	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
33421896-4	2021	Immobilisation of the CYP2C9-FLD, CYP2C9*2-FLD and CYP2C9*3-FLD on DDAB modified glassy carbon electrodes showed well defined redox couples on the oxygen-free cyclic voltammograms and mid-point potentials of all enzymes were calculated.	Oxygen	147-153	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	34-40
33421896-4	2021	Immobilisation of the CYP2C9-FLD, CYP2C9*2-FLD and CYP2C9*3-FLD on DDAB modified glassy carbon electrodes showed well defined redox couples on the oxygen-free cyclic voltammograms and mid-point potentials of all enzymes were calculated.	Oxygen	147-153	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	34-40
33785835-0	2021	In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway.	Oxygen	3-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
33785835-4	2021	We observed a severe growth inhibition when ERp57 was knocked down in hypoxia (1% O2) as a consequence of downregulated c-Myc, PLK1, PDPK1 (PDK1) and AKT (PKB).	Oxygen	82-84	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-125
34051711-0	2021	Oxygen Reserve Index Guided Oxygen Titration in One Lung Ventilation With Low Fresh Gas Flow.	Oxygen	0-6	gastrin	Homo sapiens	84-87
34051711-0	2021	Oxygen Reserve Index Guided Oxygen Titration in One Lung Ventilation With Low Fresh Gas Flow.	Oxygen	28-34	gastrin	Homo sapiens	84-87
9886257-2	1999	MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen.	Oxygen	85-91	superoxide dismutase 2	Homo sapiens	0-5
34052343-2	2021	In the present study, we hypothesized that glutathionylation would fulfill a similar role for the O2 -/H2O2 sources sn-glycerol-3-phosphate dehydrogenase (G3PDH), proline dehydrogenase (PRODH), and branched chain keto acid dehydrogenase (BCKDH).	Oxygen	98-100	proline dehydrogenase 1	Homo sapiens	163-184
34052343-2	2021	In the present study, we hypothesized that glutathionylation would fulfill a similar role for the O2 -/H2O2 sources sn-glycerol-3-phosphate dehydrogenase (G3PDH), proline dehydrogenase (PRODH), and branched chain keto acid dehydrogenase (BCKDH).	Oxygen	98-100	proline dehydrogenase 1	Homo sapiens	186-191
34029065-1	2021	On reacting laser-ablated manganese or iron difluorides with O2 or O3 during codeposition in solid neon or argon, infrared absorptions of several new metal oxo-fluoride molecules, including OMF2, (eta1-O2)MF2, (eta2-O3)MF2, (eta1-O2)2MF2 (M = Mn and Fe), and O2MnF, have been observed.	Oxygen	61-63	secreted phosphoprotein 1	Homo sapiens	225-229
33841100-10	2021	Increased levels of ATP, restoration of mitochondrial membrane potential, and decreased production of mitochondrial reactive oxygen species after Abeta treatment in the presence of 4mu8c showed that inhibiting the IRE1alpha-XBP1 axis effectively mitigated Abeta-induced mitochondrial dysfunction in SH-SY5Y cells.	Oxygen	125-131	X-box binding protein 1	Homo sapiens	224-228
33423297-2	2021	We have previously shown that disruption of Mss51, a mammalian skeletal muscle protein that localizes to the mitochondria, results in enhanced muscle oxygen consumption rate, increased endurance capacity, and improved limb muscle strength in mice with wildtype background.	Oxygen	150-156	MSS51 mitochondrial translational activator	Homo sapiens	44-49
9886257-2	1999	MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen.	Oxygen	190-196	superoxide dismutase 2	Homo sapiens	0-5
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	46-48	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
34014138-7	2022	It is a possible mechanism that changing the low oxygen environment in skeletal muscle through rESWT may inhibit activation of NF-kappaB/HIF-1alpha signaling pathway.	Oxygen	49-55	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	137-147
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	46-48	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	25-30
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
34000310-5	2021	The addition of NCF at 1.5% weight of starch increased the tensile strength (TS) and Young"s Modulus (YM), but decreased the elongation at break (EAB), oxygen permeability, and water vapor permeability of the CS films.	Oxygen	152-158	neutrophil cytosolic factor 4	Homo sapiens	16-19
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	25-30
33974472-5	2021	RESULTS: IG maximum oxygen consumption ( O2peak) 12%-improved POST (p = 0.05) and declined to baseline values T24, while CG  O2peak increased 12% T24 (p = 0.01).	Oxygen	20-26	solute carrier family 35 member G1	Homo sapiens	62-66
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	Rho guanine nucleotide exchange factor 12	Homo sapiens	189-194
33949206-10	2021	In conclusion, the data indicate that FADH2 may be pivotal for normal lung development, and show that ENaC is a key factor in promoting alveologenesis, sustaining AFC, and attenuating fibrotic lung injury caused by prolonged oxygen therapy in WT mice.	Oxygen	225-231	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	102-106
33949308-3	2021	The net surface charge of the oxygen-storing muscle protein myoglobin (ZMb), which can be readily determined from its primary structure, provides an objective target to address this question due to mechanistic linkages with myoglobin concentration.	Oxygen	30-36	myoglobin	Homo sapiens	60-69
33949308-3	2021	The net surface charge of the oxygen-storing muscle protein myoglobin (ZMb), which can be readily determined from its primary structure, provides an objective target to address this question due to mechanistic linkages with myoglobin concentration.	Oxygen	30-36	myoglobin	Homo sapiens	224-233
11670819-19	1998	The BNP(-) group bridges the pair of metal ions through its two oxygens, together with two phenolic oxygens of (L)(2)(-).	Oxygen	64-71	natriuretic peptide B	Homo sapiens	4-7
33951651-6	2021	RESULTS: The study demonstrated that cells lacking IGF2 exhibited a significant increase in reactive oxygen levels with apoptosis patterns.	Oxygen	101-107	insulin like growth factor 2	Homo sapiens	51-55
33829572-5	2021	Oxygen partial pressure (  p O 2    )-dependent electrochemical impedance spectroscopy studies reveal that while the three surfaces have different gas-exchange kinetics, the reaction mechanisms and rate-limiting steps are the same (i.e., charge-transfer to the diatomic oxygen species).	Oxygen	0-6	gastrin	Homo sapiens	147-150
11670819-19	1998	The BNP(-) group bridges the pair of metal ions through its two oxygens, together with two phenolic oxygens of (L)(2)(-).	Oxygen	100-107	natriuretic peptide B	Homo sapiens	4-7
9852050-6	1998	When the oxygen concentration in the system was decreased, the rate of O-2 production and cytochrome c reduction by antimycin-treated reductase decreased.	Oxygen	9-15	LOC104968582	Bos taurus	90-102
33454557-1	2021	In this study, the process of decomposition of carbon tetrachloride (CCl4) vapor in oxygen DBD at atmospheric pressure and its kinetic regularities have been studied.	Oxygen	84-90	C-C motif chemokine ligand 4	Homo sapiens	69-73
9870556-0	1998	Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway.	Oxygen	11-17	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	21-50
34047464-0	2021	A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species.	Oxygen	104-110	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	8-13
9870556-1	1998	Iron containing 3-Hydroxyanthranilate oxidase (3HAO) converts 3-hydroxyanthranilate (3HAA) and dioxygen into a precursor which spontaneously converts to quinolinic acid (QA).	Oxygen	95-103	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	16-45
9870556-1	1998	Iron containing 3-Hydroxyanthranilate oxidase (3HAO) converts 3-hydroxyanthranilate (3HAA) and dioxygen into a precursor which spontaneously converts to quinolinic acid (QA).	Oxygen	95-103	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	47-51
9870556-11	1998	The apparent oxygen Km of 3HAO is far higher than the oxygen concentration in brain cells.	Oxygen	13-19	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	26-30
9870556-11	1998	The apparent oxygen Km of 3HAO is far higher than the oxygen concentration in brain cells.	Oxygen	54-60	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	26-30
33078410-5	2021	The genetic deletion of TRPV4 did not affect postnatal developmental angiogenesis but increased pathological neovascularization in response to oxygen-induced retinopathy (OIR).	Oxygen	143-149	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	24-29
9819237-1	1998	The aromatic amino acid hydroxylases tyrosine and phenylalanine hydroxylase both contain non-heme iron, utilize oxygen and tetrahydrobiopterin, and are tetramers of identical subunits.	Oxygen	112-118	phenylalanine hydroxylase	Homo sapiens	50-75
33580284-8	2021	The number of cutaneous neuroepithelial cells (presumptive O2 chemoreceptors) was significantly higher in the VEGF morphants and thus the cardiorespiratory impairment in the morphants during hypoxia was unlikely related to inadequate peripheral O2 sensing.	Oxygen	59-61	vascular endothelial growth factor Aa	Danio rerio	110-114
33580284-8	2021	The number of cutaneous neuroepithelial cells (presumptive O2 chemoreceptors) was significantly higher in the VEGF morphants and thus the cardiorespiratory impairment in the morphants during hypoxia was unlikely related to inadequate peripheral O2 sensing.	Oxygen	245-247	vascular endothelial growth factor Aa	Danio rerio	110-114
9819237-3	1998	The hydroxyl oxygens of tyrosine 371 in tyrosine hydroxylase and of tyrosine 325 of phenylalanine hydroxylase are 5 and 4.5 A, respectively, away from the active site iron in the enzymes.	Oxygen	13-20	phenylalanine hydroxylase	Homo sapiens	84-109
18301567-6	1998	Varying the oxygen partial pressure during deposition made it possible to obtain films whose complex refractive index changed at the transition from SnO to SnO(2).	Oxygen	12-18	strawberry notch homolog 1	Homo sapiens	149-152
33305362-6	2021	Cav-1 deficiency induced dysregulation of oxidative lipidomics and reduction in energy consumption/production in the retina by decreasing Na+ /K+ -ATPase, oxidative phosphorylation CII, cytochrome c and oxygen consumption rate(OCR).	Oxygen	203-209	caveolin 1, caveolae protein	Mus musculus	0-5
18301567-6	1998	Varying the oxygen partial pressure during deposition made it possible to obtain films whose complex refractive index changed at the transition from SnO to SnO(2).	Oxygen	12-18	strawberry notch homolog 1	Homo sapiens	156-159
33281095-7	2021	Compared to NOR and CON, heart rate was +6-10% higher (p=0.001), whilst arterial oxygen saturation (-12-13%) was lower (p<0.001) in HYP.	Oxygen	81-87	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	132-135
11477890-6	1998	In REM sleep, the changes in MBP showed significantly correlation with the changes in oxygen saturation during apnea (r = 0.598, P &lt; 0.05).	Oxygen	86-92	myelin basic protein	Homo sapiens	29-32
33631173-2	2021	Apoptosis signal regulating kinase 1 (ASK1) is a reactive oxygen species-driven kinase involved in IS-mediated adverse effects.	Oxygen	58-64	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-36
9763626-9	1998	Radioligand binding analysis with [3H]CGS21680, a selective A2A receptor ligand, showed that the number of adenosine A2A receptor binding sites was similarly increased during exposure to 10% O2 for 48 h. 5.	Oxygen	191-193	adenosine A2a receptor	Rattus norvegicus	107-129
33631173-2	2021	Apoptosis signal regulating kinase 1 (ASK1) is a reactive oxygen species-driven kinase involved in IS-mediated adverse effects.	Oxygen	58-64	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	38-42
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	ribosomal oxygenase 2	Homo sapiens	15-19
33932464-7	2021	Based on these findings, we found a small-molecule drug, M12, that interrupted the TRPV4-Nox2 interaction, thereby reducing inflammatory factors and reactive oxygen species production and helping to restore the vasodilatory function.	Oxygen	158-164	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	83-88
33512450-9	2021	We discuss potential mechanisms through which SGLT2-inhibitors improve retinal hypoxia - through ketone bodies which are energetically as efficient as glucose and yield more ATP per molecule of oxygen consumed than fat, along with less oxidative stress.	Oxygen	194-200	solute carrier family 5 member 2	Homo sapiens	46-51
9760253-2	1998	Bovine lens aldose reductase (ALR2) is inactivated by copper ion [Cu(II)] through an oxygen-independent oxidative modification process.	Oxygen	85-91	lens aldose reductase pseudogene	Bos taurus	30-34
9893946-8	1998	These results suggest that the expression of mitochondrial encoded subunits (CO-I, CO-II and F0F1-ATPase 6) is up-regulated in response to oxygen and NO reactive species.	Oxygen	139-145	mitochondrially encoded ATP synthase 6	Homo sapiens	93-106
33886261-5	2021	The appropriate content of Pr substitution at Fe sites increases the oxygen vacancy concentration of the material, promotes the reaction on the oxygen electrode, and shows excellent electrochemical performance and efficient catalytic activity.	Oxygen	69-75	transmembrane protein 37	Homo sapiens	27-29
33886261-5	2021	The appropriate content of Pr substitution at Fe sites increases the oxygen vacancy concentration of the material, promotes the reaction on the oxygen electrode, and shows excellent electrochemical performance and efficient catalytic activity.	Oxygen	144-150	transmembrane protein 37	Homo sapiens	27-29
9722512-5	1998	This was confirmed since the sod1 mutant could be made more resistant by treatment with the superoxide anion scavenger MnCl2, or by freezing in the absence of oxygen, or by the generation of a rho0 petite.	Oxygen	159-165	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	29-33
33881798-3	2021	The high-stability of these molecular sites in CHA is a key to intrinsic structure-performance descriptions of elemental steps such as O2 dissociation, and subsequent oxidation catalysis of industrial interest, such as the combustion of methane, propane, and CO.	Oxygen	135-137	transcription factor like 5	Homo sapiens	47-50
33881798-5	2021	For oxidation processes that require the activation of rather inert molecules at high T, like alkanes, catalytic combustion is attributed to stable single Pt atoms when the support is CHA, generated in situ in the O2 stream.	Oxygen	214-216	transcription factor like 5	Homo sapiens	184-187
32640082-9	2021	Reductions in leptin level was correlated with changes in apnea hypopnea index (AHI) (r = 0.61, P = .002) and minimum oxygen saturation (SaO2) (r = -0.54, P = .008).	Oxygen	118-124	leptin	Homo sapiens	14-20
9722559-2	1998	Fet3p is proposed to facilitate iron uptake by catalyzing the oxidation of Fe(II) to Fe(III) by O2; in this model, Fe(III) is the substrate for the iron permease, encoded by FTR1.	Oxygen	96-98	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
33277949-6	2021	The epitopes for the mAbs on insulin were found well separated from each other as expected from luminiscent oxygen channeling immunoassay results for different insulins (HI, PI, bovine insulin, DesB30 HI, insulin glargine, insulin lispro).	Oxygen	108-114	insulin	Bos taurus	29-36
33592181-6	2021	Cells expressing other CYPs had an even stronger effect, with those expressing CYP2B6, CYP5A1, CYP2A13, CYP51A1, or CYP1A2, respectively, being the strongest producers of O2- .	Oxygen	171-174	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	116-122
9736026-4	1998	When FGF2-deficient mice were compared with wild-type mice in a murine model of oxygen-induced ischemic retinopathy, they developed the same amount of retinal neovascularization.	Oxygen	80-86	fibroblast growth factor 2	Mus musculus	5-9
33243650-0	2021	Oxygen-rich bismuth oxybromide nanosheets coupled with Ag2O as Z-scheme nano-heterostructured plasmonic photocatalyst: Solar light-activated photodegradation of dye pollutants.	Oxygen	0-6	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	55-58
32597241-10	2021	IGFBP-1 correlated specifically to N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (r = 0.44, p < .002), mean right atrial pressure (r = 0.41, p < .004), venous oxygen saturation (r = -0.43, p < .003), cardiac index (r = -0.32, p < .03) and 6-minute walking distance (r = -0.29, p < .05).	Oxygen	176-182	insulin like growth factor binding protein 1	Homo sapiens	0-7
33847185-5	2021	As master regulator of the hypoxic signaling pathway, HIF-1alpha is known to dampen the circadian amplitude under reduced oxygen availability, while the hypoxic response of cells and organisms, itself, is tightly clock controlled.	Oxygen	122-128	hypoxia inducible factor 1, alpha subunit	Mus musculus	54-64
9726238-5	1998	Hypoxia (0.5% O2, 5% CO2, and 94.5% N2) stimulated GLUT1 mRNA expression in BRECs in a time-dependent manner with an 8.9 +/- 1.5-fold (P &lt; 0.01) increase observed after 12 h. GLUT1 mRNA expression returned to baseline (1.4 +/- 0.3-fold of control) within 12 h after reinstitution of normoxia.	Oxygen	14-16	solute carrier family 2 member 1	Bos taurus	51-56
33834418-0	2021	HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species.	Oxygen	137-143	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	6-11
33503814-5	2021	Other studies suggest that stimulation of NOD1 or NOD2 by their bacterial ligands can result in inflammation, altered insulin responses, increased reactive oxygen signaling, and mitochondrial dysfunction.	Oxygen	156-162	nucleotide-binding oligomerization domain containing 1	Mus musculus	42-46
33498264-8	2021	Interestingly, select members of the CX9C protein family, including MNRR1 and CHCHD10, show a novel feature in that they not only localize to the mitochondria but also to the nucleus, where they mediate oxygen- and stress-induced transcriptional regulation, opening a new view of mitochondrial-nuclear crosstalk and its involvement in human disease.	Oxygen	203-209	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	78-85
9728926-2	1998	Because these patients" red blood cells (RBCs) contain mainly two Hb species, HbH and HbA, the high proportion of HbA can be exploited by lowering its oxygen affinity; this would probably increase oxygen delivery to the RBCs and improve the patients" clinical phenotype.	Oxygen	151-157	hemoglobin subunit alpha 1	Homo sapiens	78-81
33537093-4	2021	Methods: The functional role of Nur77 in hypoxia-induced EMT was examined by scattering assays to monitor the morphologies of CRC cell lines under 1% O2.	Oxygen	150-152	nuclear receptor subfamily 4, group A, member 1	Mus musculus	32-37
32572800-6	2021	On day 14 post-therapy, significant amelioration in the circulating levels of the studied cytokines was not observed in the calves treated with BUPA, while the calves treated with BUPA + OXY revealed significant (P <= 0.04) amelioration in the circulating tumour necrosis factor-alpha (TNF-alpha) level.	Oxygen	187-190	tumor necrosis factor	Bos taurus	286-295
32572800-8	2021	Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-alpha (P <= 0.0001) and IL-10 (P <= 0.012) contents, and significant elevation in IFN-gamma (P <= 0.0002) content on day 14 post-therapy.	Oxygen	41-44	tumor necrosis factor	Bos taurus	86-95
9728926-2	1998	Because these patients" red blood cells (RBCs) contain mainly two Hb species, HbH and HbA, the high proportion of HbA can be exploited by lowering its oxygen affinity; this would probably increase oxygen delivery to the RBCs and improve the patients" clinical phenotype.	Oxygen	197-203	hemoglobin subunit alpha 1	Homo sapiens	78-81
33629519-6	2021	Altogether, this led to an increase in intracellular lipid accumulation during preadipocyte differentiation, coupled with an increase in adrenaline-induced oxygen consumption mediated by neuropeptide B.	Oxygen	156-162	neuropeptide B	Rattus norvegicus	187-201
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Oxygen	63-65	cystathionine beta-synthase	Mus musculus	231-234
33519668-11	2020	Both MALAT1 downregulation and miR-375 upregulation reversed the inhibitory effect of oxygen and glucose deprivation (OGD)/R on cell viability and the promoting effects on LDH level, cell apoptosis, and inflammatory factors levels.	Oxygen	86-92	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	5-11
33346275-1	2021	Myoglobin (Mb) is considered as the optimal system for capturing molecular oxygen (O2) in aqueous solution under natural conditions.	Oxygen	75-81	myoglobin	Homo sapiens	0-9
33346275-1	2021	Myoglobin (Mb) is considered as the optimal system for capturing molecular oxygen (O2) in aqueous solution under natural conditions.	Oxygen	83-85	myoglobin	Homo sapiens	0-9
33792566-6	2021	Transcriptional studies implicated hypoxia-inducible factor-1alpha (HIF1alpha) in the induction of miR122 and identified the oxygen-sensing prolyl hydroxylase domain 1 (PHD1) as a miR122 target.	Oxygen	125-131	microRNA 122	Mus musculus	180-186
9728926-10	1998	In both cases, the oxygen equilibrium curves (OECs) were biphasic due to the presence of the noncooperative, high-oxygen-affinity HbH (beta4) component.	Oxygen	19-25	hemoglobin subunit alpha 1	Homo sapiens	130-133
9728926-10	1998	In both cases, the oxygen equilibrium curves (OECs) were biphasic due to the presence of the noncooperative, high-oxygen-affinity HbH (beta4) component.	Oxygen	19-25	tubulin beta 3 class III	Homo sapiens	135-140
9728926-10	1998	In both cases, the oxygen equilibrium curves (OECs) were biphasic due to the presence of the noncooperative, high-oxygen-affinity HbH (beta4) component.	Oxygen	114-120	hemoglobin subunit alpha 1	Homo sapiens	130-133
33413477-0	2021	Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment.	Oxygen	122-128	microRNA 573	Homo sapiens	0-7
9728926-10	1998	In both cases, the oxygen equilibrium curves (OECs) were biphasic due to the presence of the noncooperative, high-oxygen-affinity HbH (beta4) component.	Oxygen	114-120	tubulin beta 3 class III	Homo sapiens	135-140
33413477-3	2021	In this study, we aimed to investigate the role of miR-573 in human degenerative nucleus pulposus (NP) cells following hyperbaric oxygen (HBO) treatment.	Oxygen	130-136	microRNA 573	Homo sapiens	51-58
34012567-7	2021	Results: The amounts of elastin, muscle, and collagen and the protein levels of ET-1, HIF-1alpha, Rock-1, and MMP-2, increased significantly with decreased oxygen saturation in the perfusion circuit.	Oxygen	156-162	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	86-96
9728926-14	1998	Our findings provide an experimental model for lowering the oxygen affinity of HbA in HbH-containing cells and suggest that the oxygen delivery capability of the latter would be thereby improved.	Oxygen	60-66	hemoglobin subunit alpha 1	Homo sapiens	86-89
33413076-14	2021	The expression levels of circRIMS2 and BDNF in the oxygen and glucose deprivation-treated (OGD-treated) cells were decreased, the miR-186 expression and cell apoptosis were increased, while the effect was weakened after transfection with the lentiviral vector pLO-ciR-RIMS2.	Oxygen	51-57	brain derived neurotrophic factor	Mus musculus	39-43
9728926-14	1998	Our findings provide an experimental model for lowering the oxygen affinity of HbA in HbH-containing cells and suggest that the oxygen delivery capability of the latter would be thereby improved.	Oxygen	128-134	hemoglobin subunit alpha 1	Homo sapiens	86-89
33676096-9	2021	Owing to the upregulated expression of acyl-CoA synthetase long-chain family member 4 detected in the yolk sac, we assumed that the ferroptosis of the yolk sac was perhaps caused by the accumulation of reactive oxygen species, which was induced by the large amount of polyunsaturated fatty acids and influx of iron in the yolk.	Oxygen	211-217	acyl-CoA synthetase long chain family member 4	Gallus gallus	39-85
9744650-11	1998	Whole-body oxygen consumption also increased with TSC, reaching 75% of the normal resting value after about 15 min.	Oxygen	11-17	solute carrier family 12 member 3	Rattus norvegicus	50-53
33848794-4	2021	Remarkably, when cultured at a physiological oxygen tension of 1% O2, a 10-fold reduction in CD45+ hematopoietic cells associated with a concomitant increase in PDGFRalpha+ stromal cells occur.	Oxygen	45-51	protein tyrosine phosphatase, receptor type, C	Mus musculus	93-97
33848794-4	2021	Remarkably, when cultured at a physiological oxygen tension of 1% O2, a 10-fold reduction in CD45+ hematopoietic cells associated with a concomitant increase in PDGFRalpha+ stromal cells occur.	Oxygen	66-68	protein tyrosine phosphatase, receptor type, C	Mus musculus	93-97
32838528-3	2021	Myoglobin is a monomeric heme protein with a molecular weight of 17 kDa that is found in skeletal and cardiac tissue as an intracellular storage unit of oxygen.	Oxygen	153-159	myoglobin	Homo sapiens	0-9
33848794-6	2021	In standard tissue culture conditions of 21% O2, CD45+ cells showed increased proliferation coupled with no changes in cell death compared to their counterparts grown at 1% O2.	Oxygen	45-47	protein tyrosine phosphatase, receptor type, C	Mus musculus	49-53
9701579-5	1998	When overexpressed in yeast lacking the superoxide dismutase gene SOD1, both ATX1 and CCH protected the cell from the reactive oxygen toxicity that results from superoxide dismutase deficiency.	Oxygen	127-133	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	66-70
33848794-6	2021	In standard tissue culture conditions of 21% O2, CD45+ cells showed increased proliferation coupled with no changes in cell death compared to their counterparts grown at 1% O2.	Oxygen	173-175	protein tyrosine phosphatase, receptor type, C	Mus musculus	49-53
33966199-3	2021	The aim of this study was to examine the relationship between muscle hemoglobin oxygen (HbO2) and myoglobin (MbO2) desaturation using NIRS combined with venous blood sampling and HbO2 desaturation during forearm muscle exercise.	Oxygen	80-86	myoglobin	Homo sapiens	98-107
33966199-8	2021	RSO2 (%) vs VO2 Sat showed a two-component HbO2 desaturation suggesting representation of venous HbO2 desaturation and perhaps myoglobin oxygen (MBO2) desaturation.	Oxygen	137-143	myoglobin	Homo sapiens	127-136
33450350-1	2021	BACKGROUND: Leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1A) are involved in the pathogenesis of multiple sclerosis (MS) by affecting the inflammatory response and reactive oxygen species production.	Oxygen	243-249	leptin	Homo sapiens	12-18
33069734-3	2021	The goal of this work was to evaluate the role of Sesn1 in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury in vitro.	Oxygen	59-65	sestrin 1	Homo sapiens	50-55
9715819-3	1998	As with other beta-blockers, blockade of cardiac beta-adrenergic receptors (both beta1 and beta2), and hence reduction of cardiac work load and oxygen consumption, plays an important role in the actions of this agent.	Oxygen	144-150	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	91-96
9668619-6	1998	Results obtained in an animal model close to a pathophysiological condition, such as ischemia reperfusion of the liver as well as in a cell-free system involving an enzymatic source of O2 and H2O2, indicate that IRP is downregulated by oxidative stress.	Oxygen	185-187	Wnt family member 2	Homo sapiens	212-215
32243505-9	2021	Therefore, the linkage between erythrocytosis and the reduction in heart failure events with SGLT2 inhibitors may be related to a shared underlying molecular mechanism that is triggered by the action of these drugs to induce a perceived state of oxygen and nutrient deprivation.	Oxygen	246-252	solute carrier family 5 member 2	Homo sapiens	93-98
32433818-1	2021	BACKGROUND: Cerebral O2 saturation (ScO2 ) reflects cerebral perfusion and can be measured noninvasively by near-infrared spectroscopy (NIRS).	Oxygen	21-23	synthesis of cytochrome C oxidase 2	Homo sapiens	36-40
33140469-7	2021	Moreover, knockdown of Phospho1 decreases the OXPHO protein levels and mitochondria density, whereas overexpression of Phospho1 upregulates OXPHO protein levels and promotes mitochondrial oxygen consumption.	Oxygen	188-194	phosphoethanolamine/phosphocholine phosphatase 1	Homo sapiens	119-127
33724853-6	2021	An oxygen-quenchable triplet state (T1) of AI3 was produced upon 416 nm excitation in both water and n-octanol.	Oxygen	3-9	family with sequence similarity 83 member H	Homo sapiens	43-46
33499656-9	2021	Inducible enhancement of the Kvbeta1:Kvbeta2 ratio in Kv1 channels of arterial smooth muscle abolished L-lactate-induced vasodilation and suppressed the relationship between MBF and cardiac workload.Conclusions: The Kvbeta proteins differentially regulate vascular tone and myocardial blood flow, whereby Kvbeta2 promotes and Kvbeta1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand.	Oxygen	345-351	potassium voltage-gated channel, shaker-related subfamily, beta member 2	Mus musculus	37-44
33499656-9	2021	Inducible enhancement of the Kvbeta1:Kvbeta2 ratio in Kv1 channels of arterial smooth muscle abolished L-lactate-induced vasodilation and suppressed the relationship between MBF and cardiac workload.Conclusions: The Kvbeta proteins differentially regulate vascular tone and myocardial blood flow, whereby Kvbeta2 promotes and Kvbeta1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand.	Oxygen	345-351	potassium voltage-gated channel, shaker-related subfamily, beta member 2	Mus musculus	305-312
33724614-6	2021	In contrast, Oxygen-Ozone therapy notably decreased the expression level of miR-146a in treated patients.	Oxygen	13-19	microRNA 146a	Homo sapiens	76-84
33724516-9	2021	Reactive oxygen species and LDs induced by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1 hepa .	Oxygen	9-15	SAFB like transcription modulator	Homo sapiens	62-65
9668619-8	1998	Moreover, the concerted action of O2 and H2O2 produced by xanthine oxidase in a cell-free system caused a remarkable inhibition of IRP activity.	Oxygen	34-36	Wnt family member 2	Homo sapiens	131-134
9668619-11	1998	Conceivably, downregulation of IRP activity by O2 and H2O2 may facilitate iron sequestration into ferritin, thus limiting the pro-oxidant challenge of iron.	Oxygen	47-49	Wnt family member 2	Homo sapiens	31-34
34028725-4	2021	Here, we describe methods for synthesizing and expressing the novel FLIM-FRET intracellular O2 probe Myoglobin-mCherry (Myo-mCherry) in cultured cell lines, as well as acquiring FLIM images using a laser scanning confocal microscope configured for two-photon excitation and a time-correlated single photon counting (TCSPC) module.	Oxygen	92-94	myoglobin	Homo sapiens	101-110
9620775-3	1998	The association between mutations in the gene encoding the oxygen radical metabolizing enzyme CuZn superoxide dismutase (SOD1) and loss of motorneurons in the brain and spinal cord that occurs in the life-shortening paralytic disease, Familial Amyotrophic Lateral Sclerosis (FALS; ref.	Oxygen	59-65	Superoxide dismutase 1	Drosophila melanogaster	121-125
32043277-1	2021	VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2 ) regulated target of the PCO branch of the PRT6 N-degron pathway of ubiquitin-mediated proteolysis.	Oxygen	105-111	VEFS-Box of polycomb protein	Arabidopsis thaliana	0-14
32043277-1	2021	VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2 ) regulated target of the PCO branch of the PRT6 N-degron pathway of ubiquitin-mediated proteolysis.	Oxygen	105-111	VEFS-Box of polycomb protein	Arabidopsis thaliana	16-20
33661300-9	2021	HbS modification by MetAP2 inhibition increases oxygen affinity, as measured by decreased oxygen tension at which hemoglobin is 50% saturated.	Oxygen	48-54	methionine aminopeptidase 2	Mus musculus	20-26
33661300-9	2021	HbS modification by MetAP2 inhibition increases oxygen affinity, as measured by decreased oxygen tension at which hemoglobin is 50% saturated.	Oxygen	90-96	methionine aminopeptidase 2	Mus musculus	20-26
33661300-11	2021	MetAP2 inhibitor-treated Townes mice reach 50% total HbS modification, significantly increasing the affinity of RBCs for oxygen, increasing whole blood single-cell RBC oxygen saturation, and decreasing fractional flow velocity losses in blood rheology under decreased oxygen pressures.	Oxygen	121-127	methionine aminopeptidase 2	Mus musculus	0-6
33661300-11	2021	MetAP2 inhibitor-treated Townes mice reach 50% total HbS modification, significantly increasing the affinity of RBCs for oxygen, increasing whole blood single-cell RBC oxygen saturation, and decreasing fractional flow velocity losses in blood rheology under decreased oxygen pressures.	Oxygen	168-174	methionine aminopeptidase 2	Mus musculus	0-6
33661300-11	2021	MetAP2 inhibitor-treated Townes mice reach 50% total HbS modification, significantly increasing the affinity of RBCs for oxygen, increasing whole blood single-cell RBC oxygen saturation, and decreasing fractional flow velocity losses in blood rheology under decreased oxygen pressures.	Oxygen	168-174	methionine aminopeptidase 2	Mus musculus	0-6
33351635-1	2021	A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed.	Oxygen	161-167	small nucleolar RNA, H/ACA box 63	Homo sapiens	38-43
9572732-3	1998	Analysis of individual oocytes showed that the response of MAPK to progesterone or Mos was equivalent to that of a cooperative enzyme with a Hill coefficient of at least 35, more than 10 times the Hill coefficient for the binding of oxygen to hemoglobin.	Oxygen	233-239	mitogen-activated protein kinase 1 S homeolog	Xenopus laevis	59-63
33408790-6	2021	After efficient internalization into cancer cells, Mn-MOF persistently catalyzed tumor-overexpressed H2O2 to in-situ produce O2 to relieve tumor hypoxia and decrease GSH and GPX4, which facilitated the formation of ROS and ferroptosis to kill cancer cells upon US irradiation in hypoxic tumors.	Oxygen	103-105	glutathione peroxidase 4	Mus musculus	174-178
33674383-6	2021	We identify circadian rhythms of O2 --regulated transcripts which are phased around dusk and find that O2 - is required for sucrose to promote expression of TIMING OF CAB1 (TOC1) in the evening.	Oxygen	33-35	CCT motif -containing response regulator protein	Arabidopsis thaliana	157-171
33674383-6	2021	We identify circadian rhythms of O2 --regulated transcripts which are phased around dusk and find that O2 - is required for sucrose to promote expression of TIMING OF CAB1 (TOC1) in the evening.	Oxygen	33-35	CCT motif -containing response regulator protein	Arabidopsis thaliana	173-177
33674383-6	2021	We identify circadian rhythms of O2 --regulated transcripts which are phased around dusk and find that O2 - is required for sucrose to promote expression of TIMING OF CAB1 (TOC1) in the evening.	Oxygen	33-37	CCT motif -containing response regulator protein	Arabidopsis thaliana	173-177
33683823-6	2021	We found that lower oxygen and glucose concentrations enhance the expression of mesodermal (Brachyury, KIF1A) and ectodermal (Nestin, beta-Tubulin) markers.	Oxygen	20-26	kinesin family member 1A	Homo sapiens	103-108
33494625-7	2021	In cardiomyocytes, mGCH1 overexpression induced a NO/sGC/PKG-dependent increase in glucose uptake via GLUT-1, which was instrumental in preserving mitochondrial creatine kinase activity, oxygen consumption rate, LV energetics (by 31P MRS) and myocardial function.	Oxygen	187-193	GTP cyclohydrolase 1	Mus musculus	19-24
32921645-3	2020	In a second experiment, GCs were cultured under 20% O2 for 24 h. Protein levels of TOMM20 and TFAM in GCs were lower in aged cows than in young cows, and the amount of reactive oxygen species and the mitochondrial membrane potential were higher, whereas ATP content and proliferation activity were lower, respectively.	Oxygen	52-54	translocase of outer mitochondrial membrane 20	Bos taurus	83-89
33353078-9	2020	Reactive oxygen species analysis showed that inhibition of cytosolic and plastidic G6PDH activities leads to increased H2O2 and O2- contents in highland barley under salt and drought stresses.	Oxygen	128-131	g6pdh	Hordeum vulgare	83-88
9572733-0	1998	Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change.	Oxygen	17-23	interstitial collagenase	Oryctolagus cuniculus	36-49
9590311-9	1998	Reflectance spectrophotometry disclosed that patients with low gastric pHi had also a significantly (p &lt; .05) lower hemoglobin content index (61 +/- 4 arbitrary units) than patients with normal pHi (81 +/- 3 arbitrary units), whereas oxygen saturation index was similar for both groups.	Oxygen	237-243	glucose-6-phosphate isomerase	Homo sapiens	71-74
33321986-5	2020	Enzyme kinetics of both the oxidase and cytochrome c reductase activity of Erv1 were studied using oxygen consumption analysis and spectroscopic methods.	Oxygen	99-105	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	75-79
33746978-0	2021	Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture.	Oxygen	107-113	NLR family, pyrin domain containing 3	Mus musculus	51-56
9584985-5	1998	Thus, the enhancement of the active oxygen-scavenging system that was induced by low temperature in potato tubers could result not only in a decrease of AsA but also in combined increases in APx and CAT activity whose manners were different.	Oxygen	36-42	LOC102577773	Solanum tuberosum	199-202
33657673-4	2021	We found that a diluted aqueous mixture of Tau-NHCl and H2 O2 acts as a slow and long-lasting potential source of 1 O2 .	Oxygen	59-61	microtubule associated protein tau	Homo sapiens	43-46
33657673-9	2021	We found that Tau-NHCl is more stable and adequate for the production of 1 O2 .	Oxygen	75-77	microtubule associated protein tau	Homo sapiens	14-17
33321986-7	2020	Taken together, the results of this study provide important insights into the function of Erv1 in the mitochondria, suggesting that molecular oxygen is a better substrate than cytochrome c for Erv1 in the yeast mitochondria.	Oxygen	142-148	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	90-94
33344462-5	2020	Through inhibition of PGK1, miR-16-1-3p suppressed aerobic glycolysis by decreasing glucose uptake, lactate and ATP production, and extracellular acidification rate, and increasing oxygen consumption rate in breast cancer cells.	Oxygen	181-187	phosphoglycerate kinase 1	Homo sapiens	22-26
9538265-6	1998	NT-3 prevented cell death induced by oxygen toxicity in naive cells, but not that induced by NGF deprivation in differentiated cells.	Oxygen	37-43	3'-nucleotidase	Homo sapiens	0-4
33273499-2	2020	Herein, we present phosphorescent Ir(III) complexes, (btp)2Ir(acac-DM) (Ir-1) and (btp-OH)3Ir (Ir-2), as useful O2 probes for PLIM measurement.	Oxygen	112-114	immune response 2	Mus musculus	95-99
33141936-1	2021	BACKGROUND: During vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO2 ) saturation as determined by near-infrared spectroscopy.	Oxygen	90-96	synthesis of cytochrome C oxidase 2	Homo sapiens	98-102
33345998-2	2021	Runt-related transcription factor 1 (RUNX1) has been identified as an important mediator of aberrant retinal angiogenesis in proliferative diabetic retinopathy, and its modulation has proven to be effective curbing pathological angiogenesis in experimental oxygen-induced retinopathy.	Oxygen	257-263	RUNX family transcription factor 1	Homo sapiens	0-35
33345998-2	2021	Runt-related transcription factor 1 (RUNX1) has been identified as an important mediator of aberrant retinal angiogenesis in proliferative diabetic retinopathy, and its modulation has proven to be effective curbing pathological angiogenesis in experimental oxygen-induced retinopathy.	Oxygen	257-263	RUNX family transcription factor 1	Homo sapiens	37-42
33115265-3	2020	Approach and Results: Using the mouse model of oxygen-induced retinopathy, we show that myeloid cells (CD45+IsolectinB4 [IB4]+) and particularly M2-type macrophages (CD45+ Arg1+), comprise a major source of STAT3 activation (pSTAT3) in the immature ischemic retina.	Oxygen	47-53	protein tyrosine phosphatase, receptor type, C	Mus musculus	103-119
9516462-6	1998	IRP1 inactivation was reversible since re-exposure of hypoxically-treated cells to 21% O2 increased RNA binding activity approximately 7-fold after 21 h with an increase in activity seen as early as 1-h post-reoxygenation.	Oxygen	87-89	aconitase 1	Rattus norvegicus	0-4
33115265-3	2020	Approach and Results: Using the mouse model of oxygen-induced retinopathy, we show that myeloid cells (CD45+IsolectinB4 [IB4]+) and particularly M2-type macrophages (CD45+ Arg1+), comprise a major source of STAT3 activation (pSTAT3) in the immature ischemic retina.	Oxygen	47-53	protein tyrosine phosphatase, receptor type, C	Mus musculus	103-107
33115265-6	2020	Genetic deletion of SOCS3 (suppressor of cytokine signaling 3), an endogenous inhibitor of STAT3, in myeloid cells, enhanced pathological and physiological neovascularization in oxygen-induced retinopathy, indicating that myeloid-STAT3 signaling is crucial for retinal angiogenesis.	Oxygen	178-184	suppressor of cytokine signaling 3	Mus musculus	20-25
33115265-6	2020	Genetic deletion of SOCS3 (suppressor of cytokine signaling 3), an endogenous inhibitor of STAT3, in myeloid cells, enhanced pathological and physiological neovascularization in oxygen-induced retinopathy, indicating that myeloid-STAT3 signaling is crucial for retinal angiogenesis.	Oxygen	178-184	suppressor of cytokine signaling 3	Mus musculus	27-61
33449849-0	2021	Pannexin 1 Channels Control the Hemodynamic Response to Hypoxia by Regulating O2-Sensitive Extracellular ATP in Blood.	Oxygen	78-80	pannexin 1	Mus musculus	0-10
33449849-2	2021	We hypothesized that Panx1 channels and associated ATP export contributes to hypoxic vasodilation, a mechanism that facilitates the matching of oxygen delivery to tissue metabolic demand.	Oxygen	144-150	pannexin 1	Mus musculus	21-26
33404366-8	2021	We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2.	Oxygen	145-147	cryptochrome circadian regulator 1	Homo sapiens	68-72
33378041-6	2020	The changes in the expression of miR-145-5p in H9c2 cells in normal oxygen and hypoxia were determined.	Oxygen	68-74	microRNA 145	Rattus norvegicus	33-40
9516462-12	1998	Regulation of IRP1 by changing oxygen tension may provide a novel mechanism for post-transcriptionally regulating gene expression under these stresses.	Oxygen	31-37	aconitase 1	Rattus norvegicus	14-18
32688187-3	2020	The production of H2O2 in honey requires glucose oxidase (GOx) that oxidizes glucose to gluconolactone and reduces molecular oxygen to hydrogen peroxide.	Oxygen	125-131	glucose oxidase	Apis mellifera	41-56
32688187-3	2020	The production of H2O2 in honey requires glucose oxidase (GOx) that oxidizes glucose to gluconolactone and reduces molecular oxygen to hydrogen peroxide.	Oxygen	125-131	glucose oxidase	Apis mellifera	58-61
33427761-4	2021	We recently showed that in systemic inflammation and oxidative stress associated with models of inflammation including sepsis, the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase-1 (Ido1) contributes to hypotension and decreased blood pressure through production of singlet molecular oxygen (1O2).	Oxygen	285-301	indoleamine 2,3-dioxygenase 1	Homo sapiens	162-191
33427761-4	2021	We recently showed that in systemic inflammation and oxidative stress associated with models of inflammation including sepsis, the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase-1 (Ido1) contributes to hypotension and decreased blood pressure through production of singlet molecular oxygen (1O2).	Oxygen	285-301	indoleamine 2,3-dioxygenase 1	Homo sapiens	193-197
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	BCR pseudogene 1	Homo sapiens	165-169
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier organic anion transporter family member 2B1	Homo sapiens	214-221
9516467-13	1998	These results indicate that dioxygen both modulates the sensitivity to iron-dependent transcriptional regulation and acts as substrate for Fet3 in the ferroxidase reaction catalyzed by this ceruloplasmin homologue.	Oxygen	28-36	ferroxidase FET3	Saccharomyces cerevisiae S288C	139-143
33393162-7	2021	The expression levels of a group of inflammatory genes, including interleukin-8 and chemokine (C-X-C motif) ligand 10, which are downstream of reactive oxygen species, fluctuated similarly to the observed monocyte chemoattractant protein-1 fluctuations and were reduced by febuxostat pretreatment.	Oxygen	152-158	C-X-C motif chemokine ligand 8	Canis lupus familiaris	66-117
32880215-3	2020	Predicted levels of the impurity DP-2 were lower for at least 0.2 % when the drug product was protected from oxygen after its manufacture.	Oxygen	109-115	transcription factor Dp-2	Homo sapiens	33-37
9551081-3	1998	Raf-1 can be activated by many signals that include growth factors, tumor promoters, inflammatory cytokines, calcium mobilization, DNA damaging agents, and oxygen radicals.	Oxygen	156-162	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	0-5
33122160-8	2020	P2Y4 stimulation resulted in enhanced AMPK phosphorylation and reduced reactive oxygen species generation.	Oxygen	80-86	pyrimidinergic receptor P2Y4	Rattus norvegicus	0-4
33419633-10	2021	Reactive oxygen species generation with palmitate was lower in the Pex11beta knockdown cells compared with the scrambled controls (P<0.001).	Oxygen	9-15	peroxisomal biogenesis factor 11 alpha	Mus musculus	67-76
9502405-0	1998	Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome.	Oxygen	54-60	CD40 molecule	Homo sapiens	18-22
33419633-11	2021	CONCLUSION: Pex11beta knockdown decreased peroxisome abundance, decreased palmitate mediated reactive oxygen species generation, and reversed the inhibitory effect of palmitate on insulin secretion.	Oxygen	102-108	peroxisomal biogenesis factor 11 alpha	Mus musculus	12-21
33132191-7	2020	The binding mode and quantum chemical calculations showed that the carboxyl and the amide oxygen atom of A01 were the key interaction sites between TMEM16A and A01.	Oxygen	90-96	anoctamin 1	Homo sapiens	148-155
9502405-0	1998	Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome.	Oxygen	54-60	CD40 molecule	Homo sapiens	23-27
9502405-9	1998	Strategies to disrupt CD40-CD40L interactions may offer a new mode of intervention for oxygen-induced acute respiratory distress syndrome and other inflammatory lung disorders.	Oxygen	87-93	CD40 molecule	Homo sapiens	22-26
9495817-5	1998	We confirmed that superoxide anion radical (O2-) generated from hypoxanthine-xanthine oxidase reaction decreases calmodulin content and increases 45Ca2+ efflux from the heavy fraction of canine cardiac SR vesicles; hypoxanthine-xanthine oxidase also decreases Ca2+ free within the intravesicular space of the SR with no effect on Ca2+-ATPase activity.	Oxygen	44-46	calmodulin-2	Canis lupus familiaris	113-123
32963106-2	2020	The von-Hippel Lindau tumor suppressor (pVHL), acts as a master regulator of HIF activity, and its targeting of prolyl hydroxylated HIF-alpha for proteasomal degradation under normoxia is thought to be a major mechanism for pVHL tumor suppression and cellular response to oxygen.	Oxygen	272-278	von Hippel-Lindau tumor suppressor	Danio rerio	4-38
33281553-8	2020	Functional analysis in the oxygen-induced retinopathy (OIR) murine model of ROP supported our systemic human findings at the local tissue level, demonstrating that HtrA-1 expression is elevated in both the neurosensory retina and retinal pigment epithelium by RT-PCR in the ROP disease state.	Oxygen	27-33	HtrA serine peptidase 1	Homo sapiens	164-170
9495817-7	1998	We demonstrate that activation of the channel by O2- is dependent of the presence of calmodulin and identified calmodulin as a functional mediator of O2--triggered Ca2+ release through the RyRC.	Oxygen	49-51	calmodulin-2	Canis lupus familiaris	85-95
33147411-4	2020	The pi-stacked co-assembly excels in oxygen reduction performance (major criterion for fuel cells) with a high positive E1/2 of 0.91 V (vs RHE) and a reproducible reduction peak potential of 0.90 V (vs RHE).	Oxygen	37-43	small nucleolar RNA, H/ACA box 73A	Homo sapiens	120-129
9495817-7	1998	We demonstrate that activation of the channel by O2- is dependent of the presence of calmodulin and identified calmodulin as a functional mediator of O2--triggered Ca2+ release through the RyRC.	Oxygen	49-51	calmodulin-2	Canis lupus familiaris	111-121
9495817-7	1998	We demonstrate that activation of the channel by O2- is dependent of the presence of calmodulin and identified calmodulin as a functional mediator of O2--triggered Ca2+ release through the RyRC.	Oxygen	150-152	calmodulin-2	Canis lupus familiaris	85-95
9495817-7	1998	We demonstrate that activation of the channel by O2- is dependent of the presence of calmodulin and identified calmodulin as a functional mediator of O2--triggered Ca2+ release through the RyRC.	Oxygen	150-152	calmodulin-2	Canis lupus familiaris	111-121
33037038-1	2020	The hypoxia-inducible factors 1alpha and 2alpha (HIF-1alpha and HIF-2alpha) are master regulators of the cellular response to O2.	Oxygen	126-128	endothelial PAS domain protein 1b	Danio rerio	64-74
9495817-8	1998	For the first time, we show that O2- stimulates Ca2+ release from heavy SR vesicles and suggest the importance of accessory proteins such as calmodulin in modulating the effect of O2-.	Oxygen	33-35	calmodulin-2	Canis lupus familiaris	141-151
9495817-8	1998	For the first time, we show that O2- stimulates Ca2+ release from heavy SR vesicles and suggest the importance of accessory proteins such as calmodulin in modulating the effect of O2-.	Oxygen	180-182	calmodulin-2	Canis lupus familiaris	141-151
9495817-9	1998	The decreased calmodulin content induced by oxygen-derived free radicals, especially O2-, is a likely mechanism of accumulation of cytosolic Ca2+ (due to increased Ca2+ release from SR) after reperfusion of the ischemic heart.	Oxygen	44-50	calmodulin-2	Canis lupus familiaris	14-24
33187083-4	2020	Basal levels of glycolysis (extracellular acidification rate ~3-fold higher) and particularly mitochondrial respiration (oxygen consumption rate ~5-fold higher) were significantly increased in rat aHSCs, when compared to quiescent rat HSC.	Oxygen	121-127	fucosyltransferase 1 (H blood group)	Homo sapiens	198-201
33168088-6	2020	Lung elastin was significantly lower in the 100%O2 groups at 4 weeks.	Oxygen	48-50	elastin	Mus musculus	5-12
9495817-9	1998	The decreased calmodulin content induced by oxygen-derived free radicals, especially O2-, is a likely mechanism of accumulation of cytosolic Ca2+ (due to increased Ca2+ release from SR) after reperfusion of the ischemic heart.	Oxygen	85-87	calmodulin-2	Canis lupus familiaris	14-24
9458725-0	1998	Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression.	Oxygen	10-12	tyrosine hydroxylase	Rattus norvegicus	69-89
33064486-11	2020	The BSSE correction to the largest 2-body term in the MBE was accurately estimated from the function a[1 + erf( - b R)], which is proportional to the common (overlapping) area between two Gaussian distributions whose centers are separated by R with the constants a and b fitted to the calculated BSSE corrections for the individual 2-body terms of the clusters with each basis set and R is the distance between oxygen atoms.	Oxygen	411-417	chromosome 12 open reading frame 73	Homo sapiens	114-117
9458725-1	1998	In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells.	Oxygen	52-54	tyrosine hydroxylase	Rattus norvegicus	118-138
33204889-1	2020	The present work emphasizes on the changes in the Red Sea and Dead Sea mixed waters physical properties including: temperature, pH, dissolved oxygen, density, salinity and viscosity.	Oxygen	142-148	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
33204889-1	2020	The present work emphasizes on the changes in the Red Sea and Dead Sea mixed waters physical properties including: temperature, pH, dissolved oxygen, density, salinity and viscosity.	Oxygen	142-148	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	67-70
9458725-1	1998	In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells.	Oxygen	52-54	tyrosine hydroxylase	Rattus norvegicus	140-142
9458725-1	1998	In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells.	Oxygen	67-69	tyrosine hydroxylase	Rattus norvegicus	118-138
9458725-1	1998	In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells.	Oxygen	67-69	tyrosine hydroxylase	Rattus norvegicus	140-142
33154420-3	2020	However, even under atmospheric O2 conditions stabilized HIF-2alpha protein was found in brains of adult mice.	Oxygen	32-34	endothelial PAS domain protein 1	Mus musculus	57-67
9458725-8	1998	DF and CO2+ seem to affect TH gene expression in the mechanism downstream from the H2O2 formation rather than by interfering with the H2O2-generating activity of the O2 sensor.	Oxygen	8-10	tyrosine hydroxylase	Rattus norvegicus	27-29
10503075-0	1998	Production of human recombinant bone morphogenetic protein-2A by high density culture of Escherichia coli with stationary dissolved oxygen fed-batch condition.	Oxygen	132-138	bone morphogenetic protein 2	Homo sapiens	32-61
32673675-0	2020	Cytochrome c oxidase oxygen reduction reaction induced by cytochrome c on nickel-coordination surfaces based on graphene oxide in suspension.	Oxygen	21-27	cytochrome c, somatic	Equus caballus	58-70
32673612-3	2020	We propose the concept of capillary network unit and show that the concentration and gradient of oxygen/hypoxia-induced VEGF around straight segments are lower/higher than that around vascular bifurcations; sprouting mainly occurs at straight segments and intussusception at vascular bifurcations.	Oxygen	97-103	vascular endothelial growth factor A	Rattus norvegicus	120-124
10503075-2	1998	The comparison of these two methods indicated that cultivation by keeping dissolved oxygen at 30%-40% and limiting glucose concentration could obtain BMP-2A 2.78 g/L broth, the final cell density was OD600 53 (dry cell weight 21.2 g/L), and expressed BMP-2A was 25% of the total amount of protein in E.coli.	Oxygen	84-90	bone morphogenetic protein 2	Homo sapiens	150-156
32673612-4	2020	The results indicate that the locations susceptible to sprouting and intussusception are determined by the distribution characteristics of oxygen/hypoxia-induced VEGF in the capillary network unit.	Oxygen	139-145	vascular endothelial growth factor A	Rattus norvegicus	162-166
9777366-0	1998	Evidence for upregulation and redistribution of vascular endothelial growth factor (VEGF) receptors flt-1 and flk-1 in the oxygen-injured rat retina.	Oxygen	123-129	Fms related receptor tyrosine kinase 1	Rattus norvegicus	100-105
9367530-6	1997	In the present investigation, the potential for drug activation of doxorubicin (DOX), streptonigrin (STN), and menadione (MD) by XO and XDH was assessed through oxygen consumption studies.	Oxygen	161-167	xanthine dehydrogenase	Homo sapiens	136-139
32898622-8	2020	The ATP levels of flight muscle tissues were significantly elevated in PEK OE PINK1B9 flies with the increased function of mitochondrial Electron Transport Chain (ETC) Complex I (CI) but not Complex II (CII) which is further confirmed by oxygen consumption experiments, Western Blot, and RT-PCR to examine the corresponding subunits.	Oxygen	238-244	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	71-74
9367530-9	1997	Higher oxygen consumption was observed for XDH drug activation in comparison to XO drug activation at equivalent enzyme activity for both pH levels.	Oxygen	7-13	xanthine dehydrogenase	Homo sapiens	43-46
22358881-0	1997	Effect of hypoxia duration on the oxygen-dependent production of a recombinant protein, beta-galactosidase, by an animal cell line, F6D2, with a hypoxia-inducible enhancer.	Oxygen	34-40	galactosidase beta 1	Homo sapiens	88-106
22358881-8	1997	The effects of hypoxic duration as well as oxygen concentration on the beta-galactosidase production were successfully predicated by the model.	Oxygen	43-49	galactosidase beta 1	Homo sapiens	71-89
9312270-10	1997	Thus supplying a single electron from NADPH to the heme iron permits nNOS to catalyze one full round of citrulline and NO synthesis from NOHA upon exposure to O2.	Oxygen	159-161	nitric oxide synthase 1	Homo sapiens	69-73
9439779-5	1997	Results suggest that circulating sexual steroid hormones are involved in the response of the renin-angiotensin system to the experimental conditions of environmental reduced O2 partial pressure.	Oxygen	174-176	renin	Rattus norvegicus	93-98
9277447-7	1997	The distribution of T beta RII mRNA in oxygen-exposed rat lung tissue overlapped the localization of T beta RI mRNA.	Oxygen	39-45	transforming growth factor, beta receptor 2	Rattus norvegicus	20-30
9211919-9	1997	The effects on O2 consumption, insulin secretion, and food intake were completely rescued with transgenic re-expression of beta3-ARs in white and brown adipocytes (WAT+BAT-mice), demonstrating that each of these responses is mediated exclusively by beta3-ARs in white and/or brown adipocytes, and that beta3-ARs in other tissue sites were not required.	Oxygen	15-17	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	123-128
32998848-8	2021	Peak oxygen uptake changes depended on group (P<=0.05) with increases (P<=0.01) in MIC (7+-7%, n=23) and CON (12+-18%, n=17) and no changes in CLA.	Oxygen	5-11	selectin P ligand	Homo sapiens	143-146
33412215-0	2021	Metformin prevented high glucose-induced endothelial reactive oxygen species via OGG1 in an AMPKalpha-Lin-28 dependent pathway.	Oxygen	62-68	8-oxoguanine DNA glycosylase	Homo sapiens	81-85
33571872-8	2021	Characterisation of the missense variant in SH-SY5Y cells demonstrated: i) significant alterations in neurite length and number; ii) decreased reactive oxygen species tolerance in mutation carrying cells on Tetrabutylphosphonium hydroxide induction and iii) increase in alpha-synuclein protein.	Oxygen	152-158	synuclein alpha	Homo sapiens	270-285
9225764-3	1997	We hypothesize that NGF is a mediator of oxidative homeostasis, by inducing the production of oxygen-free radical scavengers in brain tissue following injury.	Oxygen	94-100	nerve growth factor	Rattus norvegicus	20-23
32306175-0	2021	Sea level nocturnal minimal oxygen saturation can accurately detect the presence of obstructive sleep apnea in a population with high pretest probability.	Oxygen	28-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
9211537-2	1997	The results were as follows: Whole blood oxygen equilibrium curves of patients with HbH disease are biphasic because of a combination of the rectangular hyperbolic curve of HbH and the normal sigmoid curve of HbA and are shifted toward the left (P50 3.66 +/- 0.33 kPa).	Oxygen	41-47	hemoglobin subunit alpha 1	Homo sapiens	84-87
32572684-10	2021	For patients with OSAHS, serum periostin and TNF-alpha levels positively correlated with the apnea-hypopnea index (AHI) (p < 0.01) and negatively correlated with the lowest saturation oxygen (LSaO2) and mean saturation oxygen (MSaO2) (both p < 0.01).	Oxygen	184-190	periostin	Homo sapiens	31-40
32572684-10	2021	For patients with OSAHS, serum periostin and TNF-alpha levels positively correlated with the apnea-hypopnea index (AHI) (p < 0.01) and negatively correlated with the lowest saturation oxygen (LSaO2) and mean saturation oxygen (MSaO2) (both p < 0.01).	Oxygen	219-225	periostin	Homo sapiens	31-40
33605070-5	2021	The operando results indicate that the total unoccupied density of states of Pt 5d orbitals of Pt1 atoms is higher than that of Pt NPs under HER condition, and that a stable Pt oxide is formed during ORR on Pt1 /NCNS, which may suppress the adsorption and activation of O2 .	Oxygen	270-272	zinc finger protein 77	Homo sapiens	95-98
9220538-5	1997	The plasmid DNA-induced protection against oxygen toxicity was associated with the production of tumor necrosis factor (TNF) and the enhancement of pulmonary Mn-superoxide dismutase (MnSOD), CuZnSOD, and glutathione peroxidase activities.	Oxygen	43-49	tumor necrosis factor-like	Rattus norvegicus	97-118
33605070-5	2021	The operando results indicate that the total unoccupied density of states of Pt 5d orbitals of Pt1 atoms is higher than that of Pt NPs under HER condition, and that a stable Pt oxide is formed during ORR on Pt1 /NCNS, which may suppress the adsorption and activation of O2 .	Oxygen	270-272	zinc finger protein 77	Homo sapiens	207-210
33639987-9	2021	In vitro study elucidated that Notch 2 participated in the activation of ACE system and angiotensin II release, induced by midkine and triggered vascular endothelial injury by angiotensin II induced reactive oxygen species production.	Oxygen	208-214	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	73-76
9220538-5	1997	The plasmid DNA-induced protection against oxygen toxicity was associated with the production of tumor necrosis factor (TNF) and the enhancement of pulmonary Mn-superoxide dismutase (MnSOD), CuZnSOD, and glutathione peroxidase activities.	Oxygen	43-49	tumor necrosis factor-like	Rattus norvegicus	120-123
9220538-6	1997	Coadministration of plasmid DNA and anti-TNF antibody (but not nonspecific IgG) partially abolished the protective effect and reduced the pulmonary MnSOD activity, suggesting that the plasmid DNA-induced oxygen tolerance was in part mediated by the endogenous TNF and MnSOD.	Oxygen	204-210	tumor necrosis factor-like	Rattus norvegicus	41-44
33664571-8	2021	Furthermore, hemin pretreatment induced HO-1 expression in cells, which partially reduced the accumulation of reactive oxygen species induced by CuNPs and increased the levels of antioxidant enzymes.	Oxygen	119-125	heme oxygenase 1	Homo sapiens	40-44
9220538-6	1997	Coadministration of plasmid DNA and anti-TNF antibody (but not nonspecific IgG) partially abolished the protective effect and reduced the pulmonary MnSOD activity, suggesting that the plasmid DNA-induced oxygen tolerance was in part mediated by the endogenous TNF and MnSOD.	Oxygen	204-210	tumor necrosis factor-like	Rattus norvegicus	260-263
9236909-0	1997	Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production.	Oxygen	132-134	interleukin 5	Homo sapiens	84-88
33718186-6	2021	PD-L1 was affected by oxygen deprivation in only one HNSCC cell line showing increased protein amounts.	Oxygen	22-28	CD274 molecule	Homo sapiens	0-5
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	280-286	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	155-159
33632231-8	2021	Additionally, Met alleviated tumor hypoxia by reducing oxygen consumption and inducing M1-type differentiation of tumor-related macrophages, which improved the tumor immunosuppressive microenvironment.	Oxygen	55-61	SAFB like transcription modulator	Homo sapiens	14-17
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	340-346	cytochrome c oxidase subunit Va	Saccharomyces cerevisiae S288C	38-43
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	340-346	cytochrome c isoform 2	Saccharomyces cerevisiae S288C	155-159
33622297-4	2021	CASE PRESENTATION: This study reports two cases: a 19-year-old girl (case 1) and a 17-year-old girl (case 2), both with CP at Gross Motor Function Classification System V. Both patients experienced acute oxygen desaturation twice within the past year of their first visit to our department.	Oxygen	204-210	ceruloplasmin	Homo sapiens	120-122
9202747-4	1997	Expression of rat acetyltransferases responsible for acetylation of the nitrogen and the oxygen of arylamine derivatives (i.e., acetyltransferases 1 and 2) in bacterial cells has now permitted experiments which demonstrate that these enzymes exhibit good affinities for and N-acetylation of the endogenous arylalkylamines derived from tryptophan, i.e., tryptamine, 5-hydroxytryptamine (serotonin) and 5-methoxytryptamine, the immediate metabolic precursor of melatonin.	Oxygen	89-95	N-acetyltransferase 8	Rattus norvegicus	128-154
33434600-6	2021	The strain lacking LHCSR1 and knocked down in LHCSR3, thus depleted in qE, produced O2 at significantly higher rate under high light, accompanied by enhanced singlet oxygen release and PSII photodamage.	Oxygen	84-86	uncharacterized protein	Chlamydomonas reinhardtii	19-25
33434600-6	2021	The strain lacking LHCSR1 and knocked down in LHCSR3, thus depleted in qE, produced O2 at significantly higher rate under high light, accompanied by enhanced singlet oxygen release and PSII photodamage.	Oxygen	84-86	uncharacterized protein	Chlamydomonas reinhardtii	46-52
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Oxygen	104-112	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	56-60
33084132-3	2021	It is concluded that 2D NiO/CeO2 HS rich in oxygen vacancies demonstrates attractive electrocatalytic properties for both HER and OER in 1 M KOH, including low onset overpotential (eta1), eta10 and Tafel slope, excellent durability as well as large active surface area.	Oxygen	44-50	secreted phosphoprotein 1	Homo sapiens	181-185
32891753-1	2020	It is well established that myoglobin supports mitochondrial respiration through the storage and transport of oxygen as well as through the scavenging of nitric oxide.	Oxygen	110-116	myoglobin	Homo sapiens	28-37
9049173-4	1997	It was found that 8% but not 10% oxygen increased flt-1 mRNA two- to three-fold in both organs, whilst flt-4 and flk-1 mRNA were not changed by acute inspiratory hypoxia.	Oxygen	33-39	Fms related receptor tyrosine kinase 1	Rattus norvegicus	50-55
32779277-4	2020	To better understand the mechanisms behind ROS signaling from chloroplasts we have used the Arabidopsis thaliana mutant plastid ferrochelatase two (fc2) that conditionally accumulates the ROS singlet oxygen (1 O2 ) leading to chloroplast degradation and eventually cell death.	Oxygen	210-212	ferrochelatase 2	Arabidopsis thaliana	148-151
33608621-3	2021	We show that, when grown under the same stem cell enriching conditions, SHH subgroup medulloblastoma cell lines established tight, highly reproducible 3D spheroids that could be maintained for weeks in culture and formed pathophysiological oxygen gradients.	Oxygen	240-246	sonic hedgehog signaling molecule	Homo sapiens	72-75
33607153-0	2021	Long non-coding RNA RMST promotes oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells by regulating miR-204-5p/VCAM1 axis.	Oxygen	34-40	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	Mus musculus	20-24
9068641-5	1997	Under aerobic growth conditions, strains possessing ccoP and rdxB mutations both singly and in combination produced light-harvesting complexes, suggesting that normal functioning of these proteins is required to maintain repression of photosynthesis gene expression in the presence of oxygen.	Oxygen	285-291	cytochrome c oxidase accessory protein CcoG	Rhodobacter sphaeroides 2.4.1	61-65
33607153-0	2021	Long non-coding RNA RMST promotes oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells by regulating miR-204-5p/VCAM1 axis.	Oxygen	34-40	vascular cell adhesion molecule 1	Mus musculus	142-147
33412146-0	2021	Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-kappaB pathway.	Oxygen	41-47	sirtuin 1	Mus musculus	0-5
33145420-5	2020	In human serum, Cp operates under substrate-limiting low [Fe2+] but high [O2] conditions, implying the possible involvement of partially reduced intermediates in Cp catalysis.	Oxygen	74-76	ceruloplasmin	Homo sapiens	16-18
33113858-2	2020	Several mechanisms regulate the cellular response to oxygen including the prolyl hydroxylase domain (PHD)/factor inhibiting HIF (FIH)-hypoxia inducible factor (HIF) pathway, cysteamine (2-aminoethanethiol) dioxygenase (ADO) system, and the lysine-specific demethylases (KDM) 5A and KDM6A.	Oxygen	53-59	2-aminoethanethiol dioxygenase	Homo sapiens	219-222
33093455-3	2020	In addition, we found interleukin (IL)-1beta activity increased while IL-18 activity decreased in the retinas of oxygen-induced ischemic retinopathy (OIR) mice.	Oxygen	113-119	interleukin 1 alpha	Mus musculus	22-44
33433532-3	2021	This perspective article focuses on our recent efforts to assemble metal complexes of non-natural porphyrinoids within the protein matrix of myoglobin, an oxygen storage hemoprotein.	Oxygen	155-161	myoglobin	Homo sapiens	141-150
9044826-0	1997	The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.	Oxygen	17-23	thymidine phosphorylase	Homo sapiens	60-107
33741145-8	2021	Mean oxygen saturation and the percentage of time with oxygen saturation<90% (CT90) were associated with atherosclerotic burden (ebeta (95%CI) 0.932 (0.892, 0.974); 1.005 (1.002, 1.009), respectively) and total plaque (OR (95%CI) 0.88 (0.797,0.971); 1.013 (1.004,1.021), respectively).	Oxygen	55-61	kinesin family member 20B	Homo sapiens	78-82
32897035-3	2020	Recently, inhaled GM-CSF was shown to improve the partial pressure of arterial oxygen in patients with aPAP.	Oxygen	79-85	colony stimulating factor 2	Homo sapiens	18-24
9044826-2	1997	Levels of PD-ECGF protein increased 6-fold in the breast cancer cell line MDA 231 after 16 h of growth in 0.3% oxygen.	Oxygen	111-117	thymidine phosphorylase	Homo sapiens	10-17
33037242-7	2020	P50 at rest differs significantly between women and men, with women showing lower Hb-O2 affinity that is determined by higher 2,3-BPG and BPGM levels.	Oxygen	85-87	bisphosphoglycerate mutase	Homo sapiens	138-142
9012671-0	1997	Mechanism of cytochrome c oxidase-catalyzed reduction of dioxygen to water: evidence for peroxy and ferryl intermediates at room temperature.	Oxygen	57-65	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
32852952-1	2020	The most basic site of 4-aminobenzoic acid in aqueous solution is the amino nitrogen while the carbonyl oxygen is calculated to be the most basic site in the gas phase.	Oxygen	104-110	gastrin	Homo sapiens	158-161
33673376-2	2021	The hypoxia-inducible factors (HIF-1alpha, HIF-2alpha, and HIF-3alpha), are the master regulators in response to low oxygen partial pressure, modulating hypoxic gene expression and signalling transduction pathways.	Oxygen	117-123	endothelial PAS domain protein 1	Homo sapiens	43-53
33197224-4	2021	SGLT2 inhibitors lower glomerular capillary hypertension and hyperfiltration, thereby reducing the physical stress on the filtration barrier, albuminuria, and the oxygen demand for tubular reabsorption.	Oxygen	163-169	solute carrier family 5 member 2	Homo sapiens	0-5
9003396-0	1997	Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.	Oxygen	9-15	glucokinase	Rattus norvegicus	101-112
33197224-6	2021	SGLT2 inhibitors may mimic systemic hypoxia and stimulate erythropoiesis, which improves organ oxygen delivery.	Oxygen	95-101	solute carrier family 5 member 2	Homo sapiens	0-5
33561881-4	2021	Conceptually, a central advantage of microfluidic oxygenators over existing hollow-fiber membrane-based configurations is the potential for shallower channels and thinner gas transfer membranes, features that reduce oxygen diffusion distances, to result in a higher gas transfer efficiency defined as the ratio of the volume of oxygen transferred to the blood per unit time to the active surface area of the gas transfer membrane.	Oxygen	50-56	gastrin	Homo sapiens	171-174
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	55-57	SURP and G-patch domain containing 1	Homo sapiens	80-83
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	95-97	SURP and G-patch domain containing 1	Homo sapiens	80-83
32790302-5	2020	HCN was proven to be oxidized by lattice oxygen of the catalyst to CO2 and NO which enters into the NH3-SCR reaction.	Oxygen	41-47	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
33020645-4	2020	In this Perspective, we describe the understanding of the mechanisms of oxygen sensing and hypoxia signaling that resulted in the development of HIF2alpha-targeted therapies for patients with VHL-associated tumors.	Oxygen	72-78	endothelial PAS domain protein 1	Homo sapiens	145-154
32905883-9	2020	The findings are important because the mechanisms underlying alpha-Synuclein-dependent reactive oxygen species fluxes and antioxidant suppression might provide a pharmacological target in Parkinson"s disease to prevent progression from mitochondrial dysfunction and oxidative stress to cell death.	Oxygen	96-102	synuclein alpha	Homo sapiens	61-76
33561881-4	2021	Conceptually, a central advantage of microfluidic oxygenators over existing hollow-fiber membrane-based configurations is the potential for shallower channels and thinner gas transfer membranes, features that reduce oxygen diffusion distances, to result in a higher gas transfer efficiency defined as the ratio of the volume of oxygen transferred to the blood per unit time to the active surface area of the gas transfer membrane.	Oxygen	50-56	gastrin	Homo sapiens	266-269
33561881-4	2021	Conceptually, a central advantage of microfluidic oxygenators over existing hollow-fiber membrane-based configurations is the potential for shallower channels and thinner gas transfer membranes, features that reduce oxygen diffusion distances, to result in a higher gas transfer efficiency defined as the ratio of the volume of oxygen transferred to the blood per unit time to the active surface area of the gas transfer membrane.	Oxygen	50-56	gastrin	Homo sapiens	266-269
33561881-4	2021	Conceptually, a central advantage of microfluidic oxygenators over existing hollow-fiber membrane-based configurations is the potential for shallower channels and thinner gas transfer membranes, features that reduce oxygen diffusion distances, to result in a higher gas transfer efficiency defined as the ratio of the volume of oxygen transferred to the blood per unit time to the active surface area of the gas transfer membrane.	Oxygen	216-222	gastrin	Homo sapiens	266-269
33561881-4	2021	Conceptually, a central advantage of microfluidic oxygenators over existing hollow-fiber membrane-based configurations is the potential for shallower channels and thinner gas transfer membranes, features that reduce oxygen diffusion distances, to result in a higher gas transfer efficiency defined as the ratio of the volume of oxygen transferred to the blood per unit time to the active surface area of the gas transfer membrane.	Oxygen	216-222	gastrin	Homo sapiens	266-269
33561881-8	2021	While the high oxygen transfer efficiency is a promising advance toward clinical scaling of a microfluidic architecture, it is accompanied by an excessive blood pressure drop in the circuit, arising from a combination of shallow gas transfer channels and equally shallow distribution manifolds.	Oxygen	15-21	gastrin	Homo sapiens	229-232
33564132-4	2021	A refined transgenic approach in mice, utilizing the oxygen-dependent degradation (ODD) domain of HIF-1alpha fused to CreERT2 recombinase, allows us to demonstrate hypoxic cells in the performing brain under normoxia and motor-cognitive challenge, and spatially map them by light-sheet microscopy, all in comparison to inspiratory hypoxia as strong positive control.	Oxygen	53-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	98-108
33554327-5	2021	The proportion of c-kit-positive stem/progenitor cells significantly increased in peripheral blood at 3 and 24 h after oxygen exposure for either 20 or 60 min (p < .01 vs. control).	Oxygen	119-125	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	18-23
9003396-0	1997	Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.	Oxygen	161-167	glucokinase	Rattus norvegicus	101-112
9003396-2	1997	GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2.	Oxygen	54-56	glucokinase	Rattus norvegicus	0-2
33003371-7	2020	Exposure to low oxygen levels stabilized HIF-1alpha and increased CI levels in RISP and COX10 KO fibroblasts.	Oxygen	16-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	41-51
9003396-5	1997	Thus the zonal O2 gradient in liver seems to have a key role in the heterogenous expression of the GK gene.	Oxygen	15-17	glucokinase	Rattus norvegicus	99-101
9215802-5	1997	Both superoxide dismutase and catalase inhibited oxygen consumption in 1.0 mM GSH and 0.2 mM alloxan in the presence of rPLTT.	Oxygen	49-55	catalase	Sus scrofa	30-38
32970058-0	2020	Tri-(Fe/F/N)-doped porous carbons as electrocatalysts for the oxygen reduction reaction in both alkaline and acidic media.	Oxygen	62-68	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
33145509-1	2020	Background: End-tidal oxygen (ETO2) monitoring is used by anesthesiologists to quantify the efficacy of preoxygenation before intubation but is generally not used in emergency departments (EDs).	Oxygen	22-28	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	30-34
33145509-3	2020	The purpose of this investigation is to determine whether the unblinded use of ETO2 monitoring led to improvements in preoxygenation during rapid sequence intubation in the ED and also the oxygen device or technique changes that were used to achieve higher ETO2 levels.	Oxygen	121-127	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	79-83
33189439-1	2021	Hypoxia-inducible factor-2 (HIF-2), a heterodimeric transcriptional protein consisting of HIF-2alpha and aryl hydrocarbon receptor nuclear translocator (ARNT) subunits, has a broad transcriptional profile that plays a vital role in human oxygen metabolism.	Oxygen	238-244	endothelial PAS domain protein 1	Homo sapiens	90-100
33189439-1	2021	Hypoxia-inducible factor-2 (HIF-2), a heterodimeric transcriptional protein consisting of HIF-2alpha and aryl hydrocarbon receptor nuclear translocator (ARNT) subunits, has a broad transcriptional profile that plays a vital role in human oxygen metabolism.	Oxygen	238-244	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	105-151
33189439-1	2021	Hypoxia-inducible factor-2 (HIF-2), a heterodimeric transcriptional protein consisting of HIF-2alpha and aryl hydrocarbon receptor nuclear translocator (ARNT) subunits, has a broad transcriptional profile that plays a vital role in human oxygen metabolism.	Oxygen	238-244	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	153-157
8914935-5	1996	We report that XD mRNA levels, determined by RT-PCR, were increased twofold in hypoxic (3% oxygen) rat pulmonary microvascular endothelial cells relative to normoxic controls (20% oxygen).	Oxygen	91-97	xanthine dehydrogenase	Rattus norvegicus	15-17
33540681-6	2021	Besides, we compared the effect induced by CLytA-DAAO with the direct addition of hydrogen peroxide, demonstrating that the progressive generation of reactive oxygen species by CLytA-DAAO is more effective in inducing cytotoxicity than the direct addition of H2O2.	Oxygen	159-165	D-amino acid oxidase	Homo sapiens	49-53
33540681-6	2021	Besides, we compared the effect induced by CLytA-DAAO with the direct addition of hydrogen peroxide, demonstrating that the progressive generation of reactive oxygen species by CLytA-DAAO is more effective in inducing cytotoxicity than the direct addition of H2O2.	Oxygen	159-165	D-amino acid oxidase	Homo sapiens	183-187
33531400-7	2021	CD11b+ lung leukocytes isolated from infected Sirt3-/- mice showed decreased levels of enzymes involved in central mitochondrial metabolic pathways, along with increased reactive oxygen species.	Oxygen	179-185	sirtuin 3	Mus musculus	46-51
33101273-2	2020	Reactive oxygen species have been implicated in NLRP3 inflammasome activation.	Oxygen	9-15	NLR family, pyrin domain containing 3	Mus musculus	48-53
32957872-1	2021	BACKGROUND: Myoglobin is an oxygen binding protein and its dysfunction has been associated with the pathology of several human disorders.	Oxygen	28-34	myoglobin	Homo sapiens	12-21
32785297-4	2020	In this highlight, we present an overview of recent developments in the utilization of such intensified flow reactors within modular flow chemistry platforms for different gas-liquid processes involving carbon dioxide, oxygen, and other gases.	Oxygen	219-225	gastrin	Homo sapiens	172-175
32711072-7	2021	Therefore, many of renoprotective benefits of SGLT2 inhibitors may be related to their effect to promote oxygen deprivation signaling in the diabetic kidney.	Oxygen	105-111	solute carrier family 5 member 2	Homo sapiens	46-51
8914935-5	1996	We report that XD mRNA levels, determined by RT-PCR, were increased twofold in hypoxic (3% oxygen) rat pulmonary microvascular endothelial cells relative to normoxic controls (20% oxygen).	Oxygen	180-186	xanthine dehydrogenase	Rattus norvegicus	15-17
8914935-6	1996	Conversely, XD mRNA was decreased threefold within 24 h under hyperoxic (95% oxygen) conditions.	Oxygen	77-83	xanthine dehydrogenase	Rattus norvegicus	12-14
32564697-0	2020	Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification.	Oxygen	9-15	NADPH oxidase 5	Homo sapiens	24-28
8914935-7	1996	These data support the hypothesis that XD is regulated by oxygen tension in the pulmonary vasculature.	Oxygen	58-64	xanthine dehydrogenase	Rattus norvegicus	39-41
33327751-10	2021	Furthermore, the blockade of IL-1beta from macrophages into brown adipocytes restores thermogenic markers and mitochondrial oxygen consumption.	Oxygen	124-130	interleukin 1 alpha	Mus musculus	29-37
8910528-1	1996	In Saccharomyces cerevisiae, loss of cytosolic superoxide dismutase (Sod1) results in several air-dependent mutant phenotypes, including methionine auxotrophy and oxygen sensitivity.	Oxygen	163-169	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	69-73
31999938-9	2021	MiR-126 overexpression also inhibited reactive oxygen species and malondialdehyde levels and enhanced superoxide dismutase levels, as well as increased angiopoietin (Ang)1 expression and decreased Ang2 expression in H2O2-treated EPCs.	Oxygen	47-53	microRNA 126b	Rattus norvegicus	0-7
33013447-3	2020	One of the proposed molecular mechanism is based on the oxygen-sensitive alpha-subunit of hypoxia-inducible factor 1 (HIF-1alpha)-a key regulator of oxygen metabolism.	Oxygen	56-62	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
33013447-3	2020	One of the proposed molecular mechanism is based on the oxygen-sensitive alpha-subunit of hypoxia-inducible factor 1 (HIF-1alpha)-a key regulator of oxygen metabolism.	Oxygen	149-155	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
33271223-4	2021	Our results show that Adiponectin enhances basal mitochondrial oxygen consumption rate (OCR), ATP production, and spare respiratory capacity (SRC), which were all abolished by the knockdown of AMPKgamma1, inhibition of SDH complex assembly, via the knockdown of the SDH assembly factor 1 (Sdhaf1), or inhibition of SDH activity.	Oxygen	63-69	protein kinase AMP-activated non-catalytic subunit gamma 1	Homo sapiens	193-203
32813510-0	2020	Template Construction of Porous CoP/COP2 Microflowers Threaded with Carbon Nanotubes toward High-Efficiency Oxygen Evolution and Hydrogen Evolution Electrocatalysts.	Oxygen	108-114	caspase recruitment domain family member 16	Homo sapiens	32-35
8810266-4	1996	To gain further insights into these mechanisms, we explored the effects of O2 exposure on G1 cyclins and their cyclin-dependent kinases (CDKs).	Oxygen	75-77	cyclin dependent kinase 2	Homo sapiens	137-141
31818185-12	2020	Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1.	Oxygen	1310-1316	caspase 9	Homo sapiens	86-91
31818185-12	2020	Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1.	Oxygen	1310-1316	cartilage associated protein	Homo sapiens	86-90
33345970-2	2021	Metal cations are one of the main factors affecting the propensity of alpha-synuclein to aggregate, either by directly binding to it or by catalyzing the production of reactive oxygen species that oxidize it.	Oxygen	177-183	synuclein alpha	Homo sapiens	70-85
33478217-3	2021	The newly resulting MOFs with ternary (Ni, S, and N) active sites exhibited enhanced activity toward oxygen evolution reaction [e.g., Ni-MOF-A/CP: E(5 mA cm-2) = 333 mV and a low Tafel slope of 80 mV dec-1].	Oxygen	101-107	ceruloplasmin	Homo sapiens	143-145
32936353-1	2021	Melatonin improved the outcome of septic cardiomyopathy by inhibiting NLRP3 priming induced by reactive oxygen species.	Oxygen	104-110	NLR family, pyrin domain containing 3	Mus musculus	70-75
32017200-10	2020	Rather, inhibition of IL-10 production by CD73 was important for optimal reactive oxygen species (ROS) production by PMNs.	Oxygen	82-88	5' nucleotidase, ecto	Mus musculus	42-46
33575962-9	2021	Considering the modulation of neutrophil recruitment of extreme relevance for respiratory distress and lung failure prevention, we propose that P2Y14 receptor inhibition by its selective antagonist PPTN could limit neutrophil recruitment and NETosis, hence limiting excessive formation of oxygen reactive species and proteolytic activation of the kallikrein-kinin system and subsequent bradykinin storm in the alveolar septa of COVID-19 patients.	Oxygen	289-295	purinergic receptor P2Y14	Homo sapiens	144-158
8810268-6	1996	The expression of the flavohemoglobin gene, YHB1, of S. cerevisiae is sensitive to oxygen.	Oxygen	83-89	flavohemoglobin	Saccharomyces cerevisiae S288C	44-48
8883381-0	1996	Both 5" and 3" sequences of maize adh1 mRNA are required for enhanced translation under low-oxygen conditions.	Oxygen	92-98	alcohol dehydrogenase 1	Zea mays	34-38
33510218-5	2021	Using a model of oxygen-induced retinopathy (OIR), we previously observed dramatic increases in retinal endoglin that localized to neovascular structures (NV), directly correlating with levels of neovascular pathology.	Oxygen	17-23	endoglin	Homo sapiens	104-112
33487033-5	2022	Oxygen cost of running showed between-protocol differences (CP1> CP2> DP; P < 0.05; ES: 0.28 to 3.30).	Oxygen	0-6	ceruloplasmin	Homo sapiens	65-68
8883381-5	1996	An mRNA containing the 5"-UTR and the first 18 codons of adh1 in a translational fusion with the GUS coding region and followed by the 3"-UTR of adh1 was expressed 57-fold higher at 5% O2.	Oxygen	185-187	alcohol dehydrogenase 1	Zea mays	57-61
8883381-5	1996	An mRNA containing the 5"-UTR and the first 18 codons of adh1 in a translational fusion with the GUS coding region and followed by the 3"-UTR of adh1 was expressed 57-fold higher at 5% O2.	Oxygen	185-187	alcohol dehydrogenase 1	Zea mays	145-149
8883381-6	1996	Progressive deletion of adh1 5"-UTR and coding sequences reduced expression of the GUS-mRNA at 5% O2, but had little impact on expression of 40% O2.	Oxygen	98-100	alcohol dehydrogenase 1	Zea mays	24-28
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Oxygen	163-169	cytochrome p450 oxidoreductase	Mus musculus	47-78
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Oxygen	163-169	cytochrome p450 oxidoreductase	Mus musculus	80-83
8883381-10	1996	Thus, both adh1 5" and 3" mRNA sequences are required for enhanced translation in protoplasts under O2 deprivation.	Oxygen	100-102	alcohol dehydrogenase 1	Zea mays	11-15
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Oxygen	163-169	cytochrome b5 reductase 1	Mus musculus	119-125
8781483-4	1996	However, in newborn animals treated with the NO synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME), hyperoxia caused a decrease in blood flow and O2 delivery to the choroid.	Oxygen	162-164	nitric oxide synthase 3	Sus scrofa	45-56
21781693-1	1996	Xanthine oxidase exists in vivo predominantly as a NAD(+)-dependent dehydrogenase form (xanthine dehydrogenase) which can be transformed into oxygen-dependent oxidase forms as a result of sulfhydryl oxidation (reversible xanthine oxidase) or proteolysis (irreversible xanthine oxidase).	Oxygen	142-148	xanthine dehydrogenase	Rattus norvegicus	88-110
33398987-0	2021	Enhancing Bifunctional Electrocatalytic Activities of Oxygen Electrodes via Incorporating Highly Conductive Sm3+ and Nd3+ Double-Doped Ceria for Reversible Solid Oxide Cells.	Oxygen	54-60	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	117-120
33356193-0	2021	Effect of the Electron Density of the Heme Fe Atom on the Nature of Fe-O2 Bonding in Oxy Myoglobin.	Oxygen	71-73	myoglobin	Homo sapiens	89-98
33510583-11	2021	Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-kappaB-dependent inflammatory response and protects SIRT1/PGC-1alpha-dependent mitochondrial function.	Oxygen	18-21	sirtuin 1	Mus musculus	153-158
33570625-0	2021	Piezo1-xerocytosis red cell metabolome shows impaired glycolysis and increased hemoglobin oxygen affinity.	Oxygen	90-96	piezo type mechanosensitive ion channel component 1	Homo sapiens	0-6
33422127-8	2021	Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3alpha (HIF3alpha), peroxisome proliferator-activated receptor alpha (PPARalpha), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS.	Oxygen	72-78	peroxisome proliferator activated receptor alpha	Homo sapiens	158-206
33422127-8	2021	Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3alpha (HIF3alpha), peroxisome proliferator-activated receptor alpha (PPARalpha), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS.	Oxygen	72-78	peroxisome proliferator activated receptor alpha	Homo sapiens	208-217
33490812-7	2021	In 0.5% CO/0.5% O2/He mixture the best CO to CO2 conversion rates were achieved at 200  C with the BAC-CMO sample (0.011 mol CO2/(m2 h)) prepared in CCl4.	Oxygen	16-18	C-C motif chemokine ligand 4	Homo sapiens	149-153
32838528-4	2021	MG consists of eight alpha-helices connected by loops and a heme group responsible for oxygen-binding.	Oxygen	87-93	myoglobin	Homo sapiens	0-2
33146568-12	2021	The results of this study support our hypothesis that in hASM cells exposed to TNFalpha mitochondria are more fragmented, with an increase in mitochondrial biogenesis and mitochondrial volume density resulting in reduced O2 consumption rate per mitochondrion.	Oxygen	221-223	H19 imprinted maternally expressed transcript	Homo sapiens	57-61
33254449-1	2021	A novel gas-pressurized (GP) torrefaction with high oxygen removal efficiency at mild temperature was proposed in our previous work.	Oxygen	52-58	gastrin	Homo sapiens	8-11
33254449-1	2021	A novel gas-pressurized (GP) torrefaction with high oxygen removal efficiency at mild temperature was proposed in our previous work.	Oxygen	52-58	ring finger protein 130	Homo sapiens	25-27
32822946-8	2021	WHCs treated with AF own higher adsorption capacity of Cd2+, which was attributed to the higher negative charge, more exchangeable cations, and more oxygen-containing functional groups.	Oxygen	149-155	CD2 molecule	Homo sapiens	55-58
33188296-11	2021	Knockdown of PARK7 increased the production of reactive oxygen species, inducing partial apoptosis and enhancing IR sensitivity in GSCs.	Oxygen	56-62	Parkinsonism associated deglycase	Homo sapiens	13-18
33393937-8	2020	Irisin concentration at rest correlated positively with an oxidative stress marker, malondialdehyde (MDA) and negatively with an antioxidant protection marker, oxygen radical absorbance capacity (ORAC) in response to the exercise test in OA at baseline.	Oxygen	160-166	fibronectin type III domain containing 5	Homo sapiens	0-6
32946964-5	2020	MicroRNA let-7a-5p, a tumor suppressor, inhibited GLUT12 expression by targeting its 3"-untranslated region, and suppressed GLUT12-mediated TNBC tumor growth, metastasis, and glycolytic function, including alterations of glucose uptake, lactate production, ATP generation, extracellular acidification rate, and oxygen consumption rate.	Oxygen	311-317	solute carrier family 2 member 12	Homo sapiens	124-130
33146201-8	2020	Mechanistically, CTR1 knockdown or Cu chelation decreased glycolytic gene expression and downstream metabolite utilization and as a result forestalled tumor cell survival after exposure to hypoxia, which mimics oxygen deprivation elicited by transarterial embolization, a standard-of-care therapy used for patients with unresectable HCC.	Oxygen	211-217	solute carrier family 31 member 1	Homo sapiens	17-21
33353000-4	2020	We found changes in PARK2 CNV deletion and duplication carriers with ADHD in PARK2 gene and protein expression, ATP production and basal oxygen consumption rates compared to healthy and ADHD wildtype control cell lines, partly differing between HDF and mDANs and to some extent enhanced in stress paradigms.	Oxygen	137-143	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	20-25
33403267-4	2020	By incorporating 15 php diammonium phosphate (DAP) as a P-N FR, r-PUF/DAP self-extinguished 5 s after the removal of the 2nd flame application with a limited oxygen index value of 24%.	Oxygen	158-164	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	66-69
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	tight junction protein 1	Rattus norvegicus	343-347
33295657-5	2020	For O2 , the solutions to the coupled nonlinear gas and blood equations are obtained at the acinus level.	Oxygen	4-6	gastrin	Homo sapiens	48-51
33521463-0	2021	Au/Ag/Cu-Mixed Catalysts for the Eco-Friendly Oxidation of 5-Hydroxymethylfurfural and Related Compounds to Carboxylic Acids under Atmospheric Oxygen in Water.	Oxygen	143-149	ciliogenesis associated kinase 1	Homo sapiens	33-36
33297453-1	2020	beta3-adrenoreceptor (beta3-AR), a G-protein coupled receptor, has peculiar regulatory properties in response to oxygen and widespread localization.	Oxygen	113-119	adrenoceptor beta 3	Homo sapiens	0-20
33287429-8	2020	The parameters assessed by the oxygen index method and cone calorimetry, characterizing the behavior of the tested CR/BR/Zn vulcanizates under fire conditions, have shown that they constitute a low fire hazard and can be considered as non-flammable materials.	Oxygen	31-37	chromosome 12 open reading frame 73	Homo sapiens	115-120
33026147-0	2020	Novel peptide derived from IGF-2 displays anti-angiogenic activity in vitro and inhibits retinal angiogenesis in a model of oxygen-induced retinopathy.	Oxygen	124-130	insulin like growth factor 2	Homo sapiens	27-32
32342525-0	2020	KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species-mediated apoptosis.	Oxygen	84-90	kinesin family member 15	Homo sapiens	0-5
32453597-12	2020	The expression of NDRG2 in OS-RC-2 and 786-O cells was lower under hypoxia than under normal oxygen conditions.	Oxygen	93-99	NDRG family member 2	Homo sapiens	18-23
33108712-7	2020	Capillary oxygen saturation (SCO2) levels were significantly lowered as hypoxic conditions became more severe; SH > MH > N trials (P < 0.001).	Oxygen	10-16	synthesis of cytochrome C oxidase 2	Homo sapiens	29-33
31420786-11	2020	The levels of ADAMTS 3 were also found to be positively correlated with minimum SpO2 (r = 0.31, p = 0.004) and negatively correlated with BMI, AHI, oxygen desaturation index (ODI), time duration with oxygen saturation &lt; 90% (T90), and CRP (r = - 0.31 to - 0.49, p &lt; 0.05).	Oxygen	148-154	ADAM metallopeptidase with thrombospondin type 1 motif 3	Homo sapiens	14-22
32648568-5	2020	Compared with control polymers CP1 and CP2, after the introduction of Pt into CP3, the triplet state, which benefits the generation of reactive oxygen species for photodynamic therapy, was identified clearly in both CP3 and the prepared CP3 nanoparticles (CP3-NPs) by ultrafast femtosecond transient absorption (fs-TA) spectroscopy.	Oxygen	144-150	ceruloplasmin	Homo sapiens	39-42
32846824-11	2020	CONCLUSION: These data suggest cell-intrinsic and endothelial-specific Angptl4 mediates the protection of TXL against endothelial barrier breakdown during oxygen-glucose-serum deprivation and restoration under high glucose condition partly via the PPAR-alpha/Angptl4 pathway.	Oxygen	155-161	angiopoietin like 4	Homo sapiens	71-78
32445867-3	2020	Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the reduced flavin mononucleotide (FMNH2) and oxidized by oxygen or ubiquinone-2, suggesting that mitoNEET may act as a novel redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone.	Oxygen	139-145	CDGSH iron sulfur domain 1	Homo sapiens	54-62
32445867-3	2020	Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the reduced flavin mononucleotide (FMNH2) and oxidized by oxygen or ubiquinone-2, suggesting that mitoNEET may act as a novel redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone.	Oxygen	139-145	CDGSH iron sulfur domain 1	Homo sapiens	179-187
32445867-3	2020	Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the reduced flavin mononucleotide (FMNH2) and oxidized by oxygen or ubiquinone-2, suggesting that mitoNEET may act as a novel redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone.	Oxygen	263-269	CDGSH iron sulfur domain 1	Homo sapiens	54-62
32445867-3	2020	Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the reduced flavin mononucleotide (FMNH2) and oxidized by oxygen or ubiquinone-2, suggesting that mitoNEET may act as a novel redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone.	Oxygen	263-269	CDGSH iron sulfur domain 1	Homo sapiens	179-187
33154777-8	2020	Furthermore, western blot analysis revealed that 2% O2-induced upregulated hypoxia-inducible factor-2alpha (HIF-2alpha) expression decreased following downregulation of NICD3 in 786-O and ACHN cells.	Oxygen	52-54	endothelial PAS domain protein 1	Homo sapiens	75-106
33154777-8	2020	Furthermore, western blot analysis revealed that 2% O2-induced upregulated hypoxia-inducible factor-2alpha (HIF-2alpha) expression decreased following downregulation of NICD3 in 786-O and ACHN cells.	Oxygen	52-54	endothelial PAS domain protein 1	Homo sapiens	108-118
32721518-2	2020	Here we have shown that, under the conditions of a gradual decrease in dissolved oxygen (dO2), characteristic of batch culture, the global regulatory system ArcB/ArcA can play an important role in the coordinated control of extracellular superoxide and GSH fluxes and their interaction with intracellular antioxidant systems.	Oxygen	81-87	hypothetical protein	Escherichia coli	157-161
33244644-5	2020	Furthermore, the bond became stronger due to cooperativity in AS3 and AS6, for the presence of withdrawing effect of the phenyl ring, the H-bonds formed with the side chain oxygen atom.	Oxygen	173-179	PDS5 cohesin associated factor B	Homo sapiens	62-65
32663032-7	2020	By contrast, there is a 94% upregulation of citrate synthase in the heart, possibly to support circulation and thus oxygen supply to other organs.	Oxygen	116-122	citrate synthase, mitochondrial	Heterocephalus glaber	44-60
32422139-5	2020	In parallel, Rh4 inhibited aerobic glycolysis in esophageal cancer cells by hindering lactate production, glucose uptake and ATP production; reducing the extracellular acidification rate (ECAR) and oxygen consumption rate (OCR); suppressing aerobic glycolysis-related protein expression.	Oxygen	198-204	Rh blood group D antigen	Homo sapiens	13-16
8679224-6	1996	We hypothesized that during in vivo exposure to 100% oxygen (O2), type II pneumocytes synthesize and secrete ICAM-1, an important step in attracting inflammatory cells to the site of injury.	Oxygen	53-59	intercellular adhesion molecule 1	Mus musculus	109-115
8679224-6	1996	We hypothesized that during in vivo exposure to 100% oxygen (O2), type II pneumocytes synthesize and secrete ICAM-1, an important step in attracting inflammatory cells to the site of injury.	Oxygen	61-63	intercellular adhesion molecule 1	Mus musculus	109-115
32691071-0	2020	Retraction: LncRNA MALAT1up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targeting miR-145.	Oxygen	129-135	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-25
33239070-7	2020	The ROS-induced metabolic dysregulation and phosphorylation of necrosome complex by YARS were assessed using oxygen consumption rate analysis, flow cytometry analysis, and 3D cell viability assay.	Oxygen	109-115	tyrosyl-tRNA synthetase 1	Homo sapiens	84-88
8798262-4	1996	Because endothelin-1 (ET-1) produces potent pulmonary vasodilation in the fetus via EDNO release and ET-1 concentrations are increased at birth, we considered that ET-1 activity may participate in the pulmonary vasodilation that occurs with O2 ventilation.	Oxygen	241-243	EDN1	Ovis aries	8-20
33329066-7	2020	The special sensitivity of glomus cell mitochondria to changes in O2 tension is due to Hif2alpha-dependent expression of several atypical mitochondrial subunits, which are responsible for an accelerated oxidative metabolism and the strict dependence of mitochondrial complex IV activity on O2 availability.	Oxygen	66-68	endothelial PAS domain protein 1	Mus musculus	87-96
33329066-7	2020	The special sensitivity of glomus cell mitochondria to changes in O2 tension is due to Hif2alpha-dependent expression of several atypical mitochondrial subunits, which are responsible for an accelerated oxidative metabolism and the strict dependence of mitochondrial complex IV activity on O2 availability.	Oxygen	290-292	endothelial PAS domain protein 1	Mus musculus	87-96
32691071-0	2020	Retraction: LncRNA MALAT1up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targeting miR-145.	Oxygen	129-135	microRNA 145	Homo sapiens	170-177
32812311-3	2020	Comparisons of experimental and theoretical IR spectra confirmed that both the charge and spin densities of [Y(G/A)Wpi   ]+ were delocalized initially at the tryptophan indolyl ring; subsequent formation of the final [Galpha   (G/A)W]+ structure gave the highest spin density at the alpha-carbon atom of the N-terminal glycine residue, with a proton solvated by the first amide oxygen atom.	Oxygen	378-384	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	218-224
8798262-4	1996	Because endothelin-1 (ET-1) produces potent pulmonary vasodilation in the fetus via EDNO release and ET-1 concentrations are increased at birth, we considered that ET-1 activity may participate in the pulmonary vasodilation that occurs with O2 ventilation.	Oxygen	241-243	EDN1	Ovis aries	22-26
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Oxygen	239-245	aconitase 1	Homo sapiens	145-186
32707731-6	2020	Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion.	Oxygen	163-169	Cbl proto-oncogene	Homo sapiens	47-50
32707731-6	2020	Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion.	Oxygen	163-169	interleukin 1 alpha	Homo sapiens	234-242
32708430-5	2020	The inflammatory response manifested by increased cytokine levels and reactive oxygen species results in inhibition of heme oxygenase (HO-1), with a subsequent loss of cytoprotection.	Oxygen	79-85	heme oxygenase 1	Homo sapiens	135-139
33221744-5	2020	Levels of the antioxidant enzyme GPX4 were decreased in oleate/palmitate-treated HepG2 cells, and there were corresponding increases in reactive oxygen species and damage to mitochondrial cristae.	Oxygen	145-151	glutathione peroxidase 4	Homo sapiens	33-37
33155794-2	2020	We have reported that a solubilized version of the mitochondrial inner membrane ATP-dependent protease YME1L displays nucleotide binding kinetics that are sensitive to the reactive oxygen species hydrogen peroxide under a limiting ATP concentration.	Oxygen	181-187	YME1 like 1 ATPase	Homo sapiens	103-108
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Oxygen	239-245	aconitase 1	Homo sapiens	188-192
8928796-13	1996	In Kupffer cells, upregulated GLUT-1 and G-6-P dehydrogenase, together with constitutively present SOD and lack of upregulated Se-GPX, suggest an elevated capacity to produce O2- and H2O2 that is consistent with primed bacterial killing.	Oxygen	175-177	solute carrier family 2 member 1	Rattus norvegicus	30-36
33106407-1	2020	Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha, enabling the expression of angiogenic factors and genes required to maintain homeostasis under conditions of oxygen stress.	Oxygen	292-298	hypoxia inducible factor 1, alpha subunit	Mus musculus	156-166
33106407-1	2020	Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha, enabling the expression of angiogenic factors and genes required to maintain homeostasis under conditions of oxygen stress.	Oxygen	292-298	endothelial PAS domain protein 1	Mus musculus	171-181
32378445-1	2020	Within the microenvironment of solid tumors, stress associated with deficit of nutrients and oxygen as well as tumor-derived factors triggers the phosphorylation-dependent degradation of the IFNAR1 chain of type I interferon (IFN1) receptor and ensuing suppression of the IFN1 pathway.	Oxygen	93-99	interferon alpha and beta receptor subunit 1	Homo sapiens	191-197
32371255-9	2020	Interestingly, the up-regulation of superoxidase dismutase (sod) and glutathione-s-transferase (gst) was only observed in Gas1 treated group, indicating that Gas1 could function to induce higher reactive oxygen species and stronger immunomodulatory function in A. franciscana, and therefore higher survival rate.	Oxygen	204-210	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	122-126
32371255-9	2020	Interestingly, the up-regulation of superoxidase dismutase (sod) and glutathione-s-transferase (gst) was only observed in Gas1 treated group, indicating that Gas1 could function to induce higher reactive oxygen species and stronger immunomodulatory function in A. franciscana, and therefore higher survival rate.	Oxygen	204-210	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	158-162
32416448-8	2020	MFGM and PC also increased mitochondrial DNA (mtDNA) copy number, mitochondrial density and oxygen consumption rate and up-regulated the mRNA expression of mitochondria-biogenesis-related genes in vitro.	Oxygen	92-98	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	0-4
33251216-5	2020	Earlier studies focused on the inhibition of MYC by HIF during hypoxia, when MYC is expressed at physiological level, to help cells survive under low oxygen conditions.	Oxygen	150-156	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	45-48
33292805-4	2020	The increased production of reactive oxygen species and DNA damage responses are causatively attributed to HSC aging.	Oxygen	37-43	fucosyltransferase 1 (H blood group)	Homo sapiens	107-110
33225123-0	2020	Estimation of Gas Holdup Using the Gassed to Ungassed Power Ratio of an Oxygen-Water System in a Stirred and Sparged Tank Contactor.	Oxygen	72-78	gastrin	Homo sapiens	14-17
8964135-7	1996	The citrate synthase activity correlated with the maximal oxygen uptake (r = 0.61, P &lt; 0.05).	Oxygen	58-64	citrate synthase	Homo sapiens	4-20
33074687-3	2020	In addition to the beta-ligand transferase activity, the Caenorhabdiitis elegans CblC (ceCblC) and clinical R161G/Q variants of the human protein exhibit robust thiol oxidase activity, converting glutathione to glutathione disulfide while concomitantly reducing O2 to H2O2.	Oxygen	262-264	Cbl proto-oncogene C	Homo sapiens	81-85
33074687-4	2020	The chemical efficiency of the thiol oxidase side reaction during ceCblC-catalyzed dealkylation of alkylcobalamins is noteworthy in that it effectively scrubs ambient oxygen from the reaction mixture, leading to air stabilization of the highly reactive cob(I)alamin product.	Oxygen	167-173	metabolism of cobalamin associated B	Homo sapiens	104-107
32319636-1	2020	Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that is activated in low oxygen conditions.	Oxygen	89-95	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
32403080-4	2020	Herein we present a Forster resonance energy transfer (FRET)-based oxygen sensor, Myoglobin-mCherry, compatible with fluorescence lifetime imaging (FLIM)-based measurement of nicotinamide coenzyme state.	Oxygen	67-73	myoglobin	Homo sapiens	82-91
8621733-1	1996	Reduced tension of O2 slows the degradation rate of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line.	Oxygen	19-21	tyrosine hydroxylase	Rattus norvegicus	61-81
32189529-7	2020	In ADSCs, LIF was upregulated in both oxygen concentrations, whereas Angpt1 was upregulated only at 1% O2.	Oxygen	38-44	LIF interleukin 6 family cytokine	Homo sapiens	10-13
33089564-4	2020	p-RTP is associated with the unique semi-rigidified SA chains, effective hydrogen bonding network, and oxygen barrier properties of SA, whereas excitation-dependent and time-dependent afterglows should stem from the formation of diversified p-RTP emissive species with comparable but different lifetimes.	Oxygen	103-109	MORN repeat containing 4	Homo sapiens	2-5
33166084-7	2020	In particular, myoglobin, an oxygen storage and antioxidant protein, is successfully delivered into human mesenchymal stem cells (hMSCs) within 24 h. Furthermore, coacervate microvectors are implemented for the delivery of human bone morphogenetic protein 2 growth factor, inducing differentiation of hMSCs into osteoprogenitor cells.	Oxygen	29-35	myoglobin	Homo sapiens	15-24
8621733-1	1996	Reduced tension of O2 slows the degradation rate of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line.	Oxygen	19-21	tyrosine hydroxylase	Rattus norvegicus	83-85
32600307-11	2020	This suggests that the alpha7nAChR represents a potential pharmacological target for the treatment regimen of oxidative inflammatory lung injury in patients receiving oxygen therapy.	Oxygen	167-173	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	23-34
9388330-1	1996	We studied the correlation of intramucosal pH (pHi), oxygen delivery (DO2) and oxygen consumption (VO2) in 21 patients with septic shock, and found that pHi decreased dramatically (P &lt; 0.05) in nonsurvivors while it had no significant change in survivors.	Oxygen	53-59	glucose-6-phosphate isomerase	Homo sapiens	153-156
32787458-11	2020	Consistently, OSCP gene therapy attenuated reactive oxygen species and opening of mitochondrial permeability transition pore (mPTP) in the hypertrophied heart.	Oxygen	52-58	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	Mus musculus	14-18
9388330-1	1996	We studied the correlation of intramucosal pH (pHi), oxygen delivery (DO2) and oxygen consumption (VO2) in 21 patients with septic shock, and found that pHi decreased dramatically (P &lt; 0.05) in nonsurvivors while it had no significant change in survivors.	Oxygen	79-85	glucose-6-phosphate isomerase	Homo sapiens	153-156
8567693-5	1996	), as well as oxygen-derived radicals (O2-. and H2O2) and various NO donors, allow IRP to bind IREs using cytosol extract of macrophagelike RAW 264.7 cells.	Oxygen	39-43	wingless-type MMTV integration site family, member 2	Mus musculus	83-86
32977368-8	2020	However, when corticosteroids intervened the LPS-primed macrophages, it also negatively regulated NLRP3-inflammasome activation through suppressing mitochondrial reactive oxygen species (mtROS) production.	Oxygen	171-177	NLR family, pyrin domain containing 3	Mus musculus	98-103
32600097-2	2020	Meanwhile, recent studies showed that subchondral bone resided within the low-oxygen microenvironment, and our previous study revealed that hypoxia-inducible transcription factor 1alpha (HIF-1alpha) promoted osteoclastogenesis under hypoxia.	Oxygen	78-84	hypoxia inducible factor 1, alpha subunit	Mus musculus	187-197
32583230-1	2022	SGLT2 inhibitors target peripheral components of reduced oxygen flux in the diabetic patient with heart failure with preserved ejection fraction.	Oxygen	57-63	solute carrier family 5 member 2	Homo sapiens	0-5
32493757-5	2020	IH-dependent HIF1a signaling caused a two-fold increase in expression of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4).	Oxygen	86-92	hypoxia inducible factor 1, alpha subunit	Mus musculus	13-18
8567693-8	1996	Moreover, we show that 3-morpholinosydnonimine (SIN-1), a chemical which releases both NO and O2-.	Oxygen	94-97	mitogen-activated protein kinase associated protein 1	Mus musculus	48-53
33363343-11	2020	Oxygen tension culture conditions of 1% and 3% O2 led to OCT4 and SOX2 expression on culture days 2 and 4 (p<0.05), respectively, as compared to the hyperoxia condition (21% O2).	Oxygen	0-6	transcription factor SOX-2	Oryctolagus cuniculus	66-70
33363343-11	2020	Oxygen tension culture conditions of 1% and 3% O2 led to OCT4 and SOX2 expression on culture days 2 and 4 (p<0.05), respectively, as compared to the hyperoxia condition (21% O2).	Oxygen	47-49	transcription factor SOX-2	Oryctolagus cuniculus	66-70
33292642-3	2020	To minimize side effects, we designed a hypoxia-inducible CAR (HiCAR), which is driven by a hypoxia response element (HRE), and consists of a conventional CAR and an oxygen-dependent degradation domain (ODD) that is actively degraded under normoxia but stabilized under hypoxia.	Oxygen	166-172	CXADR pseudogene 1	Homo sapiens	58-61
33292642-3	2020	To minimize side effects, we designed a hypoxia-inducible CAR (HiCAR), which is driven by a hypoxia response element (HRE), and consists of a conventional CAR and an oxygen-dependent degradation domain (ODD) that is actively degraded under normoxia but stabilized under hypoxia.	Oxygen	166-172	CXADR pseudogene 1	Homo sapiens	65-68
32463675-6	2020	The fabricated CoP/SPNF electrocatalyst exhibits impressive bifunctional performance for the hydrogen evolution reaction (HER, overpotential of 45 mV at 10 mA cm-2) and oxygen evolution reaction (OER, overpotential of 215 mV at 80 mA cm-2) and consequently enables efficient electrolytic water splitting with a low cell voltage of 1.547 V at 30 mA cm-2 and a prominent durability.	Oxygen	169-175	caspase recruitment domain family member 16	Homo sapiens	15-18
32401514-5	2020	Was there any impact of atomic oxygen in production of early atmospheric HCN for the emergence of life?	Oxygen	31-37	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
32401514-9	2020	We propose that addition reactions of atomic oxygen with CH3NO and CH2NO  might act as potential source for early atmospheric HCN.	Oxygen	45-51	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	126-129
8561775-5	1996	Furthermore, cells subjected to a severe hypoxic condition (0.5% O2) for 24 hours exerted a 22% reduction in MR expression and a 64% increase in GR expression.	Oxygen	65-67	nuclear receptor subfamily 3 group C member 2	Homo sapiens	109-111
32581712-8	2020	Overexpression or knockdown of METTL3 in oxygen-glucose deprivation of PC12 cells resulted in functional maturation of miR-335, SG formation and apoptosis levels.	Oxygen	41-47	methyltransferase-like 3	Rattus norvegicus	31-37
33192328-3	2020	The purpose of the present study is to explore the expression and action of IDO in stem cell culture under oxygen and glucose deprivation.	Oxygen	107-113	indoleamine 2,3-dioxygenase 1	Homo sapiens	76-79
33192328-8	2020	Results: IDO expression in neural progenitor cells increased under oxygen and glucose deprivation, which is closely associated with cell death (p < 0.05).	Oxygen	67-73	indoleamine 2,3-dioxygenase 1	Homo sapiens	9-12
33192328-10	2020	However, inhibiting IDO could attenuate cell viability under oxygen and glucose deprivation (p < 0.05).	Oxygen	61-67	indoleamine 2,3-dioxygenase 1	Homo sapiens	20-23
33192328-12	2020	Conclusions: Our results demonstrated that an increase of IDO under oxygen and glucose deprivation was associated with cell death, suggesting that inhibiting IDO could be a target for neuroprotection.	Oxygen	68-74	indoleamine 2,3-dioxygenase 1	Homo sapiens	58-61
33192328-12	2020	Conclusions: Our results demonstrated that an increase of IDO under oxygen and glucose deprivation was associated with cell death, suggesting that inhibiting IDO could be a target for neuroprotection.	Oxygen	68-74	indoleamine 2,3-dioxygenase 1	Homo sapiens	158-161
9244168-4	1996	These results suggest that LPS can directly reduce normal cellular oxygen consumption possibly via a CD14-independent pathway.	Oxygen	67-73	CD14 molecule	Homo sapiens	101-105
33195239-6	2020	Moreover, we discovered that SPCA1 depletion in oxygen and glucose deprivation/reoxygenation (OGD/R)-treated N2a cells mitigated the protective effects of OM-MSCs.	Oxygen	48-54	ATPase secretory pathway Ca2+ transporting 1	Rattus norvegicus	29-34
33195440-2	2020	The reactivity of this position of the reduced isoalloxazine ring with the dioxygen ground-state triplet established the C4a as a site capable of one-electron chemistry.	Oxygen	75-83	complement C4A (Rodgers blood group)	Homo sapiens	121-124
31675438-7	2020	In the presence of 6-shogaol, osteoclast signaling including the RANKL-induced activation of mitogen-activated protein kinases, Ca2+ oscillation, generation of reactive oxygen species, and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) nuclear translocation was significantly inhibited in vitro.	Oxygen	169-175	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	65-70
32040844-9	2020	PKM2 knockdown cells exhibit significantly lower migration compared to control cells when subjected to glucose and oxygen deprivation, but not under regular conditions.	Oxygen	115-121	pyruvate kinase M1/2	Homo sapiens	0-4
32902955-6	2020	In the Na-O2/CO2/Ag nanobattery, the discharge reactions were essentially the same as the Na-O2/CO2/CNT nanobattery, however, the charge reaction in the former was very sluggish, suggesting that direct decomposition of Na2CO3 is difficult.	Oxygen	10-12	complement C2	Homo sapiens	13-19
8660263-4	1996	RESULTS: Regardless of the substrate used, HLF caused a 80-90% and 20-40% reduction in myocardial oxygen uptake and coronary flow rate, respectively.	Oxygen	98-104	HLF transcription factor, PAR bZIP family member	Rattus norvegicus	43-46
33114456-1	2020	Endothelial PAS domain-containing protein 1 (EPAS1) is an oxygen-sensitive component of the hypoxia-inducible factors (HIFs) having reported implications in many cancers by inducing a pseudo-hypoxic microenvironment.	Oxygen	58-64	endothelial PAS domain protein 1	Homo sapiens	0-43
33114456-1	2020	Endothelial PAS domain-containing protein 1 (EPAS1) is an oxygen-sensitive component of the hypoxia-inducible factors (HIFs) having reported implications in many cancers by inducing a pseudo-hypoxic microenvironment.	Oxygen	58-64	endothelial PAS domain protein 1	Homo sapiens	45-50
32592328-7	2020	Severe hypoxia (7% O2, 4 hr) caused a 400-fold increase in deglycosylated Epo expression in rat kidneys, which is consistent with the increases in both Epo gene expression and plasma Epo concentration.	Oxygen	19-21	erythropoietin	Rattus norvegicus	74-77
32592328-7	2020	Severe hypoxia (7% O2, 4 hr) caused a 400-fold increase in deglycosylated Epo expression in rat kidneys, which is consistent with the increases in both Epo gene expression and plasma Epo concentration.	Oxygen	19-21	erythropoietin	Rattus norvegicus	152-155
7578122-8	1995	These data indicate that Zn(2+)-dependent inhibition of nNOS activity is due to binding of Zn2+ to the hemoprotein domain in the enzyme and that inhibition is associated with perturbations in the environment of the heme iron that appear to block its ability to mediate oxygen reduction.	Oxygen	269-275	nitric oxide synthase 1	Homo sapiens	56-60
32592328-7	2020	Severe hypoxia (7% O2, 4 hr) caused a 400-fold increase in deglycosylated Epo expression in rat kidneys, which is consistent with the increases in both Epo gene expression and plasma Epo concentration.	Oxygen	19-21	erythropoietin	Rattus norvegicus	152-155
32485834-2	2020	Insufficient supply of oxygen and/or nutrients upregulates factors such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), which can induce abnormal angiogenesis and damage the structural arrangement of the retinal blood barrier (BRB).	Oxygen	23-29	epidermal growth factor	Homo sapiens	121-144
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Oxygen	221-227	mannosidase endo-alpha	Homo sapiens	64-68
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Oxygen	221-227	mannosidase endo-alpha	Homo sapiens	252-256
33093455-0	2020	Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model.	Oxygen	154-160	NLR family, pyrin domain containing 3	Mus musculus	15-20
33093455-0	2020	Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model.	Oxygen	154-160	interleukin 1 alpha	Mus musculus	114-122
32936630-7	2020	S(IV) is further oxidized to SO42- in the presence of triplet sensitizers and oxygen.	Oxygen	78-84	IV	Homo sapiens	0-5
32485834-2	2020	Insufficient supply of oxygen and/or nutrients upregulates factors such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), which can induce abnormal angiogenesis and damage the structural arrangement of the retinal blood barrier (BRB).	Oxygen	23-29	epidermal growth factor	Homo sapiens	112-115
32509410-8	2020	Biochemical oxygen demand exceeded the recommended limits of the Department of Environment and Natural Resources (DENR) of 7.0 ppm with values of 13.22 ppm (upstream) and 12.02 ppm (downstream).	Oxygen	12-18	density regulated re-initiation and release factor	Homo sapiens	114-118
7491990-2	1995	Therefore in the current study we utilized BQ-123 to test the hypothesis that blockade of the ETA receptor can reverse as well as prevent the increase in mean pulmonary artery pressure, right ventricle-to-left ventricle plus septum ratio, and percent wall thickness in small (50-100 microns) pulmonary arteries observed in male Sprague-Dawley rats exposed to normobaric hypoxia (10% O2, 2 wk).	Oxygen	383-385	endothelin receptor type A	Rattus norvegicus	94-97
32439831-7	2020	NADPH oxidase 5 (NOX5) was identified as a potential target of miR-15a-3p, and the inhibition of NOX5 reduced the release of reactive oxygen species, thereby impairing the functionality of human umbilical vein endothelial cells.	Oxygen	134-140	NADPH oxidase 5	Homo sapiens	0-15
32439831-7	2020	NADPH oxidase 5 (NOX5) was identified as a potential target of miR-15a-3p, and the inhibition of NOX5 reduced the release of reactive oxygen species, thereby impairing the functionality of human umbilical vein endothelial cells.	Oxygen	134-140	NADPH oxidase 5	Homo sapiens	17-21
33082354-13	2020	Vessels from Cav-1-/- mice exhibited increased O2- generation and phosphorylation of ERM.	Oxygen	47-49	caveolin 1, caveolae protein	Mus musculus	13-18
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
7474505-9	1995	2) The percentage of maximal oxygen uptake at the onset of decrease in %CPAH and %CIN were 35 and 49%VO2max, respectively, while %CPAH and %CIN began to decrease at 75 and 105%VT, respectively.	Oxygen	29-35	pyridoxal phosphatase	Homo sapiens	82-85
33066332-1	2020	Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway.	Oxygen	190-196	solute carrier family 7 member 5	Homo sapiens	130-135
32265299-3	2020	Because cancer cells have increased levels of reactive oxygen species, xCT, responsible for cystine-glutamate exchange, is overexpressed in many cancers, including glioblastoma.	Oxygen	55-61	solute carrier family 7 member 11	Homo sapiens	71-74
32319294-2	2020	This reaction utilizes Sc(OTf)3 as a Lewis acid and TEMPO as an oxygen scavenger.	Oxygen	64-70	POU class 5 homeobox 1	Homo sapiens	23-31
7673128-4	1995	Deletional and mutational analysis of the function of mouse LDH-reporter fusion gene constructs in transient transfection assays defined three domains, between -41 and -84 base pairs upstream of the transcription initiation site, which were crucial for oxygen-regulated expression.	Oxygen	253-259	lactate dehydrogenase A	Mus musculus	60-63
32018232-3	2020	2D MoS2 nanosheet in the hydrogel was simultaneously utilized as photothermal agent and photodynamic agent for the generation of hyperthermia and reactive oxygen species, respectively.	Oxygen	155-161	mago homolog, exon junction complex core component	Mus musculus	3-7
33031409-2	2020	Considering the severity of the disease and the lack of active treatments, 14 patients with Covid-19 and severe lung inflammation received inhaled adenosine in the attempt to therapeutically compensate for the oxygen-related loss of the endogenous adenosine A2A adenosine receptor (A2AR)-mediated mitigation of the lung-destructing inflammatory damage.	Oxygen	210-216	adenosine A2a receptor	Homo sapiens	258-280
32745469-0	2020	miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN.	Oxygen	55-61	phosphatase and tensin homolog	Homo sapiens	118-122
8704828-2	1995	: J Neurochem 1992;58:1538] demonstrated the relationship between low O2 breathing and tyrosine hydroxylase (TH) gene expression in chemosensory type I cells of the carotid body.	Oxygen	70-72	tyrosine hydroxylase	Rattus norvegicus	87-107
32173524-8	2020	Compared with normoxia, a 10% oxygen environment promoted myogenin and the expression of mTOR, p70s6K, and the metabolic signal AMPK.	Oxygen	30-36	myogenin	Mus musculus	58-66
32173524-8	2020	Compared with normoxia, a 10% oxygen environment promoted myogenin and the expression of mTOR, p70s6K, and the metabolic signal AMPK.	Oxygen	30-36	mechanistic target of rapamycin kinase	Mus musculus	89-93
32712192-7	2020	Through biochemical characterization of the reactivity of the non-acetylated/N-terminally acetylated soluble or membrane-bound alpha-Syn-Cu(II) complexes towards dopamine, oxygen, and ascorbate, we reveal that membrane insertion dramatically exacerbates the catechol oxidase-like reactivity of alpha-Syn-Cu(II) as a result of a change in the Cu(II) coordination environment, thereby potentiating its toxicity.	Oxygen	172-178	synuclein alpha	Homo sapiens	127-136
8704828-2	1995	: J Neurochem 1992;58:1538] demonstrated the relationship between low O2 breathing and tyrosine hydroxylase (TH) gene expression in chemosensory type I cells of the carotid body.	Oxygen	70-72	tyrosine hydroxylase	Rattus norvegicus	109-111
7479707-4	1995	In contrast, the rates of CO, O2, and NO dissociation increased 4-, 10-, and 25-fold, respectively, for the same series of mutants, causing large decreases in the affinity of myoglobin for all three diatomic gases.	Oxygen	30-32	myoglobin	Physeter catodon	175-184
32903101-12	2020	Our data identify a specific reactive oxygen species ASK1 p38-MAPK pathway in the heart and establish that ASK1 inhibitors protect the heart from hypertension-induced cardiac remodeling.	Oxygen	38-44	mitogen-activated protein kinase kinase kinase 5	Mus musculus	53-57
32903101-12	2020	Our data identify a specific reactive oxygen species ASK1 p38-MAPK pathway in the heart and establish that ASK1 inhibitors protect the heart from hypertension-induced cardiac remodeling.	Oxygen	38-44	mitogen-activated protein kinase kinase kinase 5	Mus musculus	107-111
32275885-5	2020	We also show that in response to oxygen changes, apoptosis signal-regulating kinase 1 (ASK1) is activated and phosphorylates HDAC6, blocking its ubiquitination by von Hippel-Lindau and subsequent degradation by the proteasome.	Oxygen	33-39	mitogen-activated protein kinase kinase kinase 5	Mus musculus	49-85
32275885-5	2020	We also show that in response to oxygen changes, apoptosis signal-regulating kinase 1 (ASK1) is activated and phosphorylates HDAC6, blocking its ubiquitination by von Hippel-Lindau and subsequent degradation by the proteasome.	Oxygen	33-39	mitogen-activated protein kinase kinase kinase 5	Mus musculus	87-91
32275885-6	2020	Moreover, depletion of HDAC6 or inhibition of the ASK1/HDAC6 axis protects mice from oxygen-change-induced pathological changes of photoreceptors.	Oxygen	85-91	mitogen-activated protein kinase kinase kinase 5	Mus musculus	50-54
32088265-3	2020	Here, we report that lysosomotropic drugs potentiate pro-inflammatory effects in response to IL-1beta via a mechanism involving reactive oxygen species, p38 mitogen-activated protein kinase and reduced IL-1 receptor internalization.	Oxygen	137-143	interleukin 1 alpha	Homo sapiens	93-101
32115713-4	2020	Severe hypoxia (0.1% O2 ) induced the processing of pro-IL-1beta, pro-caspase-1, and gasdermin D, as well as the release of IL-1beta and lactate dehydrogenase in lipopolysaccharide (LPS)-primed murine macrophages, indicating that hypoxia induces NLRP3 inflammasome-driven inflammation and pyroptosis.	Oxygen	21-23	interleukin 1 alpha	Mus musculus	56-64
32115713-4	2020	Severe hypoxia (0.1% O2 ) induced the processing of pro-IL-1beta, pro-caspase-1, and gasdermin D, as well as the release of IL-1beta and lactate dehydrogenase in lipopolysaccharide (LPS)-primed murine macrophages, indicating that hypoxia induces NLRP3 inflammasome-driven inflammation and pyroptosis.	Oxygen	21-23	NLR family, pyrin domain containing 3	Mus musculus	246-251
7626092-6	1995	Raising the O2 level will favor catalysis of NO oxidation to NO2 by CcO.	Oxygen	12-14	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	68-71
31833997-0	2020	Successful Treatment of Anti-MDA5 Dermatomyositis Associated Cutaneous Digital Pulp Ulcerations With Hyperbaric Oxygen Therapy.	Oxygen	101-118	interferon induced with helicase C domain 1	Homo sapiens	29-33
31825666-4	2020	Consistently, hypoxia/reoxygenation (H/R)-treated cardiac (H9c2) cells displayed cellular injury (apoptosis and necrosis), up-regulation of total and mitochondrial protein levels of Mul1 and p53, and enhanced interactions between p53 and SUMO1 concomitant with mitochondrial dysfunctions (increase in mitochondrial membrane potential and reactive oxygen species production while decrease in ATP production); these phenomena were attenuated by knockdown of Mul1 expression.	Oxygen	24-30	mitochondrial E3 ubiquitin protein ligase 1	Rattus norvegicus	182-186
7626092-7	1995	The reactions of NO and the specific CcO activity that occur in tissue will be critically dependent on NO, O2, and CcO levels.	Oxygen	107-109	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	37-40
33000581-4	2020	Cytokines, NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome related protein including caspase-associated recruitment domain (CARD) domain Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC), caspase-1 and NOD-like receptor family, pyrin domain containing 3 (NLRP3), and reactive oxygen species were simultaneously investigated.	Oxygen	335-341	NLR family, pyrin domain containing 3	Mus musculus	63-68
7588445-2	1995	Intratracheal insufflation of anti-TNF antibodies prolonged the survival of rats exposed to 100% O2.	Oxygen	97-99	tumor necrosis factor-like	Rattus norvegicus	35-38
32659677-5	2020	RESULTS: SFN inhibited the development of reactive oxygen species in keratinocytes exposed to PM2.5.	Oxygen	51-57	RNA exonuclease 2	Homo sapiens	9-12
32072193-12	2020	Additionally, Akap1 deficiency increased cardiomyocyte apoptosis via enhanced mitochondrial reactive oxygen species (ROS) production.	Oxygen	101-107	A kinase (PRKA) anchor protein 1	Mus musculus	14-19
32044330-1	2020	Paraoxonase-2 regulates reactive oxygen species production in mitochondria.	Oxygen	33-39	paraoxonase 2	Mus musculus	0-13
7588445-5	1995	These results suggest that hyperoxia may cause the production of low level TNF, which in turn enhances O2 toxicity.	Oxygen	103-105	tumor necrosis factor-like	Rattus norvegicus	75-78
7474549-9	1995	These data suggest that NPH4 would be effective against various diseases whose pathogenesis is active oxygen-related.	Oxygen	102-108	neurexophilin 4	Rattus norvegicus	24-28
32694663-3	2020	Identified in RNA interference (RNAi) screens, NFYB-1 loss leads to perturbed mitochondrial gene expression, reduced oxygen consumption, mitochondrial fragmentation, disruption of mitochondrial stress pathways, decreased mitochondrial cardiolipin levels and abolition of organismal longevity triggered by mitochondrial impairment.	Oxygen	117-123	Nuclear transcription factor Y subunit nfyb-1	Caenorhabditis elegans	47-53
32949969-7	2020	Induction of HO-1 and GCLM by SFN (2.5 muM) was significantly attenuated in cells adapted to 5 kPa O2, despite nuclear accumulation of Nrf2.	Oxygen	99-101	glutamate-cysteine ligase, modifier subunit	Mus musculus	22-26
33062139-6	2020	Intriguingly, these above effects of BAK were largely attributed to the remarkable activation of SIRT1/Nrf2 signaling, which eventually strengthened cardiac antioxidative capacity by elevating the antioxidant production and reducing the reactive oxygen species generation.	Oxygen	246-252	sirtuin 1	Mus musculus	97-102
7611487-0	1995	Influence of O2 deprivation, reduced flow, and temperature on release of ANP from rabbit hearts.	Oxygen	13-15	natriuretic peptides A	Oryctolagus cuniculus	73-76
32948821-6	2020	The ability of C3G to reduce plasma and hepatic triglycerides, glucose tolerance, and adiposity and to induce oxygen consumption and energy expenditure was abrogated in PPARalpha-deficient mice, suggesting that PPARalpha is the major target for C3G.	Oxygen	110-116	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	15-18
33867541-7	2020	Most stardust is thought to originate in three distinct processes in carbon- and/or oxygen-rich mineral-forming stars: (1) condensation in the cooling, expanding atmospheres of asymptotic giant branch stars; (2) during the catastrophic explosions of supernovae, most commonly core collapse (Type II) supernovae; and (3) classical novae explosions, the consequence of runaway fusion reactions at the surface of a binary white dwarf star.	Oxygen	84-90	protein associated with LIN7 1, MAGUK p55 family member	Homo sapiens	5-13
32411715-5	2020	However, we found that G-CSF does not prime PMNs toward NETs formation, but increases the serum concentration of cell-free DNA, proteases like neutrophils elastase and myeloperoxidase, and reactive oxygen species.	Oxygen	198-204	colony stimulating factor 3	Homo sapiens	23-28
7611487-7	1995	In contrast, both room temperature hypoxia and ischemia were characterized by a significant decrease in ANP release, despite hemodynamic alterations similar to those recorded during hypoxia at 37 degrees C. Both reoxygenation and reperfusion induced a prompt reversal of the changes of ANP release observed during the period of oxygen deprivation.	Oxygen	214-220	natriuretic peptides A	Oryctolagus cuniculus	286-289
32984087-9	2020	Consistent with bladder ischemia, incubation of cultured human bladder smooth muscle cells at low oxygen tension increased both ASK1 and caspase-3 expression, insinuating hypoxia as an essential factor in ASK1 and caspase-3 upregulation.	Oxygen	98-104	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	128-132
7633144-1	1995	Xanthine oxidase may contribute to oxygen free radical formation during reoxygenation after hypoxia, but in humans the enzyme is present in substantial amounts only in the liver and intestine.	Oxygen	35-41	xanthine dehydrogenase	Sus scrofa	0-16
32815713-9	2020	On the extracellular side, a heme prosthetic group is at the bottom of a pocket where the substrate (O2 in NOX, chelated iron or copper in STEAP) is reduced.	Oxygen	101-103	STEAP family member 1	Homo sapiens	139-144
32784053-2	2020	Hypoxia-inducible factor-1alpha (Hif1alpha), an oxygen sensor, initiates placental vascular development.	Oxygen	48-54	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
32784053-2	2020	Hypoxia-inducible factor-1alpha (Hif1alpha), an oxygen sensor, initiates placental vascular development.	Oxygen	48-54	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-42
32233398-5	2020	Furthermore, oxygen-containing functional groups are also introduced onto the CTF nanosheets through the mid oxidation, improving surface hydrophilicity.	Oxygen	13-19	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	78-81
32296963-0	2020	Co/CoP Nanoparticles Encapsulated Within N, P-Doped Carbon Nanotubes on Nanoporous Metal-Organic Framework Nanosheets for Oxygen Reduction and Oxygen Evolution Reactions.	Oxygen	122-128	caspase recruitment domain family member 16	Homo sapiens	3-6
32296963-0	2020	Co/CoP Nanoparticles Encapsulated Within N, P-Doped Carbon Nanotubes on Nanoporous Metal-Organic Framework Nanosheets for Oxygen Reduction and Oxygen Evolution Reactions.	Oxygen	143-149	caspase recruitment domain family member 16	Homo sapiens	3-6
32248837-0	2020	HIF1alpha overexpression enhances diabetic wound closure in high glucose and low oxygen conditions by promoting adipose-derived stem cell paracrine function and survival.	Oxygen	81-87	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
7758459-0	1995	Expression of the AAC2 gene encoding the major mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is controlled at the transcriptional level by oxygen, heme and HAP2 factor.	Oxygen	151-157	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	18-22
32914752-6	2020	Mechanistically, mtCa2+ overload leads to increased mitochondrial reactive oxygen species, which activate HIF1alpha signaling supporting metastasis of NCLX-null tumor cells.	Oxygen	75-81	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	Mus musculus	151-155
31821902-2	2020	POx oxidizes several monosaccharides including D-glucose, D-galactose, and D-xylose, while concurrently oxygen is reduced to hydrogen peroxide.	Oxygen	104-110	proline dehydrogenase 1	Homo sapiens	0-3
7758459-2	1995	The intracellular level of the carrier protein, as well as the level of the AAC2-gene-specific mRNA, is influenced by the presence or absence of oxygen or of heme, and it is subject to carbon-source control.	Oxygen	145-151	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	76-80
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	Oxygen	136-142	indoleamine 2,3-dioxygenase 1	Homo sapiens	40-44
7747287-3	1995	Since TNF-alpha is known to be involved in oxygen radical generation, we also examined TNF production in response to antigen challenge.	Oxygen	43-49	tumor necrosis factor	Cavia porcellus	6-15
31898278-2	2020	Here, we show that SCA2 patient cells exhibit higher levels of caspase-8- and caspase-9-mediated apoptotic activation than control cells, cellular phenotypes that we find to be exacerbated by reactive oxygen species (ROS) and inhibition of autophagy.	Oxygen	201-207	caspase 9	Homo sapiens	78-87
32364651-5	2020	Cells collected in the middle and at the outlet of the biochips, where oxygen concentrations are lower, were characterized by the upregulation of genes involved in cellular detoxification processes (CYP450), PPAR signaling or arginine biosynthesis.	Oxygen	71-77	peroxisome proliferator activated receptor alpha	Homo sapiens	208-212
7747287-3	1995	Since TNF-alpha is known to be involved in oxygen radical generation, we also examined TNF production in response to antigen challenge.	Oxygen	43-49	tumor necrosis factor	Cavia porcellus	6-9
32557197-1	2020	PURPOSE: Non-invasive cerebral oxygen saturation (ScO2) monitoring is an established tool in the intraoperative phase of pediatric congenital cardiac surgery (CCS).	Oxygen	31-37	synthesis of cytochrome C oxidase 2	Homo sapiens	50-54
7779145-4	1995	Ceruloplasmin exhibited a cardioprotective effect and prevented the oxygen free radical-induced release of noradrenaline, indicating that it can also protect the sympathetic nerve endings from oxygen free-radical injury.	Oxygen	68-74	ceruloplasmin	Rattus norvegicus	0-13
31868937-3	2020	In the current study, we explored the potential function of microRNA-148b-3p (miR-148b-3p) in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro, a cellular model for mimicking cerebral ischemia/reperfusion injury.	Oxygen	132-146	microRNA 148b	Homo sapiens	78-86
31868937-5	2020	Importantly, miR-148b-3p overexpression decreased cell viability and exacerbated apoptosis and reactive oxygen species (ROS) production in OGD/R-exposed neurons.	Oxygen	104-110	microRNA 148b	Homo sapiens	13-21
7900827-0	1995	Basic fibroblast growth factor and growth factor receptor gene expression in 85% O2-exposed rat lung.	Oxygen	81-83	fibroblast growth factor 2	Rattus norvegicus	0-30
32125470-5	2020	In this study, the histological outcome of the hippocampal CA1 region following resuscitation with 100% O2 combined with different post-ROSC ventilation regimes (21%, 50%, and 100% O2) was investigated in a rat CA/resuscitation model with survival times of 7 and 21 days.	Oxygen	104-106	carbonic anhydrase 1	Rattus norvegicus	59-62
32125470-6	2020	Immunohistochemical stainings of NeuN, MAP2, GFAP, and IBA1 revealed a neuroprotective potency of post-ROSC ventilation with 21% O2, although it was only temporary.	Oxygen	129-131	RNA binding fox-1 homolog 3	Rattus norvegicus	33-37
32348842-7	2020	Most of which were downregulated, except the genes ldh, iclA, and ackA2 respectively encoding L-lactate dehydrogenase, isocitrate lyase, and acetate kinase were upregulated under oxygen-limiting conditions (3%, v/v).	Oxygen	179-185	H16_RS11130	Ralstonia eutropha H16	119-135
32982789-0	2020	The Mechanism of NMDA Receptor Hyperexcitation in High Pressure Helium and Hyperbaric Oxygen.	Oxygen	86-92	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	17-30
7900827-2	1995	We hypothesized that type II pneumocyte hyperplasia after exposure of young adult rats to 85% O2 in vivo would be temporally related to 1) an increased concentration of intrapulmonary basic fibroblast growth factor (bFGF), a potent stimulator of type II pneumocyte DNA synthesis in vitro, and 2) an upregulation of pneumocyte receptors for bFGF (FGF-R).	Oxygen	94-96	fibroblast growth factor 2	Rattus norvegicus	184-214
7900827-5	1995	Nuclear runoff assays confirmed increased transcription of both bFGF and flg genes in response to 85% O2, whereas increased translation at 6 days of exposure was confirmed by protein immunoanalysis.	Oxygen	102-104	fibroblast growth factor 2	Rattus norvegicus	64-68
31955862-11	2020	Further, DPP4 and METTL7A differentially activated prosurvival signaling pathways including PI3K/AKT, ERK1/2 and STAT3, and attenuated the accumulation of reactive oxygen species (ROS) in choriocarcinoma cell lines.	Oxygen	164-170	dipeptidyl peptidase 4	Homo sapiens	9-13
7900827-6	1995	Immunohistochemistry demonstrated a broad distribution of bFGF throughout the lung, including the alveolar epithelium, which increased after 6 and 14 days of exposure to 85% O2.	Oxygen	174-176	fibroblast growth factor 2	Rattus norvegicus	58-62
32697566-4	2020	Once activated by GOx-catalyzed glucose oxidation, a large amount of oxygen radicals, toxic ONOO- and NO are rapidly produced over this well-designed L-Arg/GOx@CuBDC through a double-cascade reaction.	Oxygen	69-75	hydroxyacid oxidase 1, liver	Mus musculus	18-21
32697566-4	2020	Once activated by GOx-catalyzed glucose oxidation, a large amount of oxygen radicals, toxic ONOO- and NO are rapidly produced over this well-designed L-Arg/GOx@CuBDC through a double-cascade reaction.	Oxygen	69-75	hydroxyacid oxidase 1, liver	Mus musculus	156-159
32817981-8	2020	When controlling for neutropenia, G-CSF administration was associated with increased need for high oxygen supplementation and death (HR: 2.97, 95% CI: 1.06-8.28, P value: 0.038).	Oxygen	99-105	colony stimulating factor 3	Homo sapiens	34-39
32114846-9	2020	In vascular endothelial-cadherin+Nox5+ mice with oxygen-induced retinopathy, retinal vascular permeability and neovascularization, as well as the expression of angiogenic and inflammatory factors, were increased compared with wild-type littermates.	Oxygen	49-55	NADPH oxidase 5	Bos taurus	33-37
32364989-6	2020	Lipase (LPL), glutathione peroxidase 3 (GPX3), cathelicidin-2 (CATHL2), ceruloplasmin (CP), and hemoglobin subunit alpha 1 (HBA1) cooperatively played roles in the thermal fitness of dairy buffalo by decreasing heat production and increasing blood oxygen delivery.	Oxygen	248-254	ceruloplasmin	Homo sapiens	72-85
32035131-3	2020	Here we have reviewed the functional relationship between reactive oxygen species (ROS) and PD-L1 expressed on cancer cells, and analyzed the effects of 15 pharmacological ROS modulators - both ROS inducers and attenuators - on PD-L1 expression.	Oxygen	67-73	CD274 molecule	Homo sapiens	92-97
7873200-1	1995	Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity.	Oxygen	142-144	tumor necrosis factor-like	Rattus norvegicus	48-69
32088750-8	2020	There were significant correlations between plasma vimentin levels and OSA patients" AHI and mean oxygen desaturation (r = 0.46, p = 0.001; r = 0.214, p = 0.005).	Oxygen	98-104	vimentin	Homo sapiens	51-59
32088750-9	2020	CONCLUSION: In this study, we observed significant positive correlations between plasma vimentin level and OSA severity, weight, AHI, and mean oxygen desaturation.	Oxygen	143-149	vimentin	Homo sapiens	88-96
32725149-5	2020	In vitro experiments revealed that 8-iso-PGF2alpha induced oxidative stress, release of reactive oxygen species, and cell apoptosis, which were reversed by concomitant incubation with the FXR agonist.	Oxygen	97-103	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	188-191
32776982-0	2020	Using oxygen 18 isotope to problematize the presence of resettled laborers in the far provinces of the Inca empire.	Oxygen	6-12	caspase recruitment domain family member 17	Homo sapiens	103-107
32312010-0	2020	Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1beta, platelet-derived growth factor-BB, and interleukin-1 receptor antagonist in keloids.	Oxygen	22-28	C-C motif chemokine ligand 4	Homo sapiens	109-146
7873200-1	1995	Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity.	Oxygen	142-144	tumor necrosis factor-like	Rattus norvegicus	71-74
32312010-0	2020	Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1beta, platelet-derived growth factor-BB, and interleukin-1 receptor antagonist in keloids.	Oxygen	22-28	interleukin 1 receptor antagonist	Homo sapiens	187-220
7836366-5	1995	Cells that contain a functional FET3 gene product exhibited an iron-dependent non-mitochondrial increase in oxygen consumption.	Oxygen	108-114	ferroxidase FET3	Saccharomyces cerevisiae S288C	32-36
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	C-C motif chemokine ligand 4	Homo sapiens	226-263
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	C-C motif chemokine ligand 3	Homo sapiens	265-274
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	interleukin 1 receptor antagonist	Homo sapiens	326-359
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	interleukin 1 receptor antagonist	Homo sapiens	361-367
32785675-10	2020	Conclusions: Our data support the hypothesis that EPOR signaling was associated with regrowth of vascularization following oxygen-induced capillary dropout and played a role in intravitreal angiogenesis.	Oxygen	123-129	erythropoietin receptor	Mus musculus	50-54
32596838-3	2020	The Urea-PDI performs so far highest oxygen evolution rate (3223.9 micromol g-1 h-1 ) without cocatalysts under visible light.	Oxygen	37-43	H1.5 linker histone, cluster member	Homo sapiens	80-83
7836366-8	1995	Treatment of spheroplasts with trypsin or affinity-purified antibodies directed against the putative external ferroxidase domain of Fet3 had no effect on basal O2 consumption but inhibited the iron-dependent increase in O2 consumption.	Oxygen	220-222	ferroxidase FET3	Saccharomyces cerevisiae S288C	132-136
7705297-3	1994	Oxidase-catalyzed univalent reduction of O2 (S = 1; triplet multiplicity) yields hydrodioxylic acid (HO2) and its conjugate base superoxide, O2- (S = 1/2; doublet multiplicity).	Oxygen	41-43	heme oxygenase 2	Homo sapiens	101-104
32701253-9	2020	MAIN RESULTS: In vitro testing demonstrated the oxygen-sensing capability of the BNP film and its ability to shield ambient oxygen to isolate wound oxygen.	Oxygen	48-54	natriuretic peptide type B	Mus musculus	81-84
32701253-9	2020	MAIN RESULTS: In vitro testing demonstrated the oxygen-sensing capability of the BNP film and its ability to shield ambient oxygen to isolate wound oxygen.	Oxygen	124-130	natriuretic peptide type B	Mus musculus	81-84
32701253-9	2020	MAIN RESULTS: In vitro testing demonstrated the oxygen-sensing capability of the BNP film and its ability to shield ambient oxygen to isolate wound oxygen.	Oxygen	124-130	natriuretic peptide type B	Mus musculus	81-84
31863884-0	2020	MiR-142-3p attenuates oxygen glucose deprivation/reoxygenation-induced injury by targeting FBXO3 in human neuroblastoma SH-SY5Y cells.	Oxygen	22-28	F-box protein 3	Homo sapiens	91-96
7729088-5	1994	rCBF was measured during 4-5-minutes inhalation of 33% stable xenon gas-67% oxygen.	Oxygen	76-82	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
32103212-2	2020	Monodentate (eta1) binding of the carboxylates to the metal centre favours the five-coordinate cobalt(ii) complexes (1-3) for dioxygen activation.	Oxygen	126-134	secreted phosphoprotein 1	Homo sapiens	13-17
32176866-9	2020	Blood oxygen saturation under sildenafil treatment at sea level (98% [81; 100]) was significantly higher (P = .006) compared with sildenafil treatment at moderate altitude (94% [85; 100]).	Oxygen	6-12	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
31954827-8	2020	We further show that medium exercise intensity (60%-70% of maximal oxygen uptake) was more efficacious in increasing lipid metabolism and reducing blood lipid levels and soluble Abeta levels, than low-intensity exercise (45-55% of maximal oxygen uptake).	Oxygen	67-73	amyloid beta (A4) precursor protein	Mus musculus	178-183
32024700-5	2020	In this study, we show that in addition to IL-1beta, PSTPIP2 also negatively regulates pathways governing reactive oxygen species generation by neutrophil NOX2 NADPH oxidase.	Oxygen	115-121	interleukin 1 alpha	Homo sapiens	43-51
32572680-5	2020	Therefore, it is important to identify the early alterations in structure and function of the major determinants of the oxygen transport via myoglobin and oxygen utilisation by the mitochondria in skeletal muscle at high altitude.	Oxygen	120-126	myoglobin	Homo sapiens	141-150
32473155-9	2020	Enhanced energy expenditure by GATA3 was confirmed using oxygen consumption assays, and the mitochondrial content was assessed using MitoTracker.	Oxygen	57-63	GATA binding protein 3	Mus musculus	31-36
32618988-0	2020	Electronic structural regulation of CoP nanorods by the tunable incorporation of oxygen for enhanced electrocatalytic activity during the hydrogen evolution reaction.	Oxygen	81-87	caspase recruitment domain family member 16	Homo sapiens	36-39
32618988-5	2020	Typically, the obtained O-CoP nanorods with an optimal oxygen content exhibit excellent HER activity with an overpotential of 116 mV at a current density of 10 mA cm-2 and a small Tafel slope of 59 mV dec-1 in alkaline media.	Oxygen	55-61	caspase recruitment domain family member 16	Homo sapiens	24-29
7923153-5	1994	Since Ras and Raf-1 have been previously shown to work downstream from membrane-associated tyrosine kinases such as Src, we determined if the Src membrane-associated kinase was also activated by low oxygen conditions.	Oxygen	199-205	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
32589395-3	2020	We produced recombinant human MAO A variants at Lys305 that plays a key role in O2 reactivity leading to H2O2 production.	Oxygen	80-82	monoamine oxidase A	Homo sapiens	30-35
32053750-4	2020	The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback.	Oxygen	410-416	serpin family E member 2	Homo sapiens	64-67
7930518-0	1994	The histochemical G6PDH reaction but not the LDH reaction with neotetrazolium is suitable for the oxygen sensitivity test to detect cancer cells.	Oxygen	98-104	glucose-6-phosphate dehydrogenase	Rattus norvegicus	18-23
32036249-6	2020	SLC7A11-AS1 promotes chemoresistance through reducing intracellular reactive oxygen species (ROS) by stabilizing nuclear factor erythroid-2-related factor 2 (NRF2), the key regulator in antioxidant defense.	Oxygen	77-83	SLC7A11 antisense RNA 1	Homo sapiens	0-11
32680528-12	2020	CONCLUSIONS: Dopaminergic neurons have the potential to accumulate NLRP3 inflammasome activators with age, including reactive oxygen species, dopamine metabolites, and misfolded proteins.	Oxygen	126-132	NLR family, pyrin domain containing 3	Mus musculus	67-72
7930518-1	1994	We used the oxygen sensitivity of the histochemical reaction to detect glucose-6-phosphate dehydrogenase (G6PDH) activity based on neotetrazolium (NT) reduction to discriminate cancer cells from normal cells.	Oxygen	12-18	glucose-6-phosphate dehydrogenase	Rattus norvegicus	71-104
8089148-3	1994	We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity.	Oxygen	204-206	aldolase, fructose-bisphosphate A	Homo sapiens	56-66
32516529-8	2020	That oxidation of the enzyme by dioxygen can be suppressed by the addition of pyrimidine, is consistent with these electrons residing on the FMN.	Oxygen	32-40	formin 1	Homo sapiens	141-144
32130553-4	2020	Moreover, Jph@1.23V can be further enhanced 25-folds compared to the untreated counterpart via the post-rapid thermal process (RTP), which is used to introduce the defect doping of oxygen vacancy.	Oxygen	181-187	junctophilin 1	Homo sapiens	10-15
8089148-3	1994	We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity.	Oxygen	204-206	aldolase, fructose-bisphosphate A	Homo sapiens	68-72
7981784-1	1994	In BHK-21 cells (baby hamster kidney fibroblasts) cellularly generated active oxygen species such as hydrogen peroxide and superoxide appear to be important growth regulatory signals as judged from the growth inhibitory effects of catalase, superoxide dismutase and superoxide dismutase mimics.	Oxygen	78-84	catalase	Mesocricetus auratus	231-239
32073260-6	2020	This indicates that, although TrxR may be a potential target for anticancer metal complexes, it is unlikely the main target or the sole target for the Ru, Os, and Ir compounds described here, and other targets should be considered.	Oxygen	155-157	peroxiredoxin 5	Homo sapiens	30-34
31923762-3	2020	Specifically, NanoTRAIL (TRAIL/Apo2L-iron oxide nanoparticles) generated ROS (reactive oxygen species)-triggered JNK (c-Jun N-terminal kinase) activation and induced subsequent autophagy-assisted DR5 upregulation, resulting in a significant enhanced antitumor efficacy of TRAIL/Apo2L, which confirmed in both TRAIL-resistant HT-29, intermediately resistant SW-480 and sensitive HCT-116 cells.	Oxygen	87-93	TNF receptor superfamily member 10b	Homo sapiens	196-199
32874480-2	2020	The aim of this study was to identify the effect of different doses of hyperbaric oxygen (HBO) exposure in reducing inflammation on ACIA through analysis hypoxia inducible factor-1alpha (HIF-1alpha), anticyclic citrullinated peptide antibody (ACPA) and interleukine 17a (IL-17a).	Oxygen	82-88	hypoxia inducible factor 1, alpha subunit	Mus musculus	154-185
32874480-2	2020	The aim of this study was to identify the effect of different doses of hyperbaric oxygen (HBO) exposure in reducing inflammation on ACIA through analysis hypoxia inducible factor-1alpha (HIF-1alpha), anticyclic citrullinated peptide antibody (ACPA) and interleukine 17a (IL-17a).	Oxygen	82-88	hypoxia inducible factor 1, alpha subunit	Mus musculus	187-197
32401675-2	2020	Previous work has shown that the Alveolar Gas Meter (AGM100) can measure pulmonary gas exchange, via the OD, in patients with a history of lung disease and in normal subjects breathing 12.5% O2.	Oxygen	191-193	gastrin	Homo sapiens	42-45
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Oxygen	166-172	hemopexin	Homo sapiens	57-59
32017988-4	2020	We have identified a key microRNA, let-7g, which levels were drastically diminished as consequence of transient middle cerebral artery occlusion(tMCAO) in vivo and oxygen-glucose deprivation (OGD) in vitro ischemia/reperfusion conditions, respectively.	Oxygen	164-178	microRNA let7g	Mus musculus	35-41
31857238-7	2020	At the same time, ChO markedly facilitated beta-AR-induced reactive oxygen species (ROS) production.	Oxygen	68-74	adrenergic receptor, beta 2	Mus musculus	43-50
32483753-2	2020	Compared with day 7, at 5% O2 on day 14 spontaneous upregulation of osteo- (RUNX2, SP7, BGLAP, and SPP1) and adipogenic differentiation (CEBPA, PPARG, and ADIPOQ) genes in MSCs was observed (p < 0.05).	Oxygen	27-29	secreted phosphoprotein 1	Homo sapiens	99-103
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Oxygen	182-188	hemopexin	Homo sapiens	57-59
7519309-8	1994	The involvement of active oxygen species in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, thiourea, mannitol, formate and catalase.	Oxygen	26-32	catalase	Bos taurus	164-172
31724279-0	2020	p,p"-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells.	Oxygen	78-84	pyruvate kinase M1/2	Homo sapiens	171-175
8005797-4	1994	This resulted in a reduction in p50 (the oxygen partial pressure at which hemoglobin is 50% saturated) to 78% of the control value, and a decrease in tumor blood perfusion to 73% of the control value.	Oxygen	41-47	dynactin 2	Mus musculus	32-35
31996410-2	2020	We previously reported that deficiency of endothelial HIF-2 exacerbated renal ischemia-reperfusion injury, whereas inactivation of endothelial PHD2, the main oxygen sensor, provided renoprotection.	Oxygen	158-164	egl-9 family hypoxia-inducible factor 1	Mus musculus	143-147
8209390-4	1994	The maximal induction of P450 isoenzymes CYP2B1/2B2 (20- to 25-fold) and CYP2C6 (6-fold) were found at 0.75 mM PB at both oxygen tensions.	Oxygen	122-128	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	41-51
8204590-1	1994	The proximal bond between the iron atom of the heme group and the N epsilon of histidine F8 in myoglobin (Mb) and hemoglobin (Hb) is presumed to be an important determinant of heme binding, protein structure, and oxygen binding.	Oxygen	213-219	myoglobin	Physeter catodon	95-104
8005243-5	1994	A significant correlation between diffusing capacity of the lungs for carbon monoxide (DLCO) (and carbon monoxide transfer coefficient (KCO) = DLCO/alveolar volume (VA)) and the increase in alveolar-arterial oxygen tension difference (A-aPO2) during exercise (delta A-aPO2) was observed at diagnosis (r = -0.58).	Oxygen	208-214	TNF receptor superfamily member 10a	Homo sapiens	237-241
8005243-5	1994	A significant correlation between diffusing capacity of the lungs for carbon monoxide (DLCO) (and carbon monoxide transfer coefficient (KCO) = DLCO/alveolar volume (VA)) and the increase in alveolar-arterial oxygen tension difference (A-aPO2) during exercise (delta A-aPO2) was observed at diagnosis (r = -0.58).	Oxygen	208-214	TNF receptor superfamily member 10a	Homo sapiens	268-272
8125933-11	1994	They indicate, furthermore, that hydrogen abstraction and oxygen addition occur in an antarafacial manner and suggest a specific model for binding of linoleic acid within the myoglobin active site.	Oxygen	58-64	myoglobin	Physeter catodon	175-184
8200812-0	1994	Problems related to EtO sterilization of infant oxygen hoods.	Oxygen	48-54	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	20-23
8077255-5	1994	However, PMNs exhibited unique oxygen consumption and enhanced liberation of reactive oxygen when RGDS-carrying microspheres were phagocytosed.	Oxygen	86-92	ral guanine nucleotide dissociation stimulator	Homo sapiens	98-102
8077255-7	1994	Furthermore, cytochalasin D, which inhibits actin polymerization, showed a marked inhibitory effect on oxygen consumption in the RGDS-carrying microsphere system, as compared with those in other systems.	Oxygen	103-109	ral guanine nucleotide dissociation stimulator	Homo sapiens	129-133
8190518-1	1994	Glutathione reductase catalyzes the NADPH-dependent conversion of glutathione disulfide to glutathione and helps protect the lung from injury by reactive oxygen.	Oxygen	154-160	glutathione reductase	Mus musculus	0-21
8146271-3	1994	As the DMSO concentration is increased from 10(-4) mol dm-3 to 1 mol dm-3, the SSB yield in the presence and absence of oxygen decreases by over 100-fold and less than 10-fold, respectively.	Oxygen	120-126	small RNA binding exonuclease protection factor La	Homo sapiens	79-82
8139268-10	1994	CONCLUSIONS: ADF induction in retinal pigment epithelial cells may be involved in the defense mechanism against cellular damage caused by active oxygen species generated during oxygen stress to the retina.	Oxygen	145-151	destrin, actin depolymerizing factor	Rattus norvegicus	13-16
8139268-10	1994	CONCLUSIONS: ADF induction in retinal pigment epithelial cells may be involved in the defense mechanism against cellular damage caused by active oxygen species generated during oxygen stress to the retina.	Oxygen	177-183	destrin, actin depolymerizing factor	Rattus norvegicus	13-16
8024462-6	1994	ECL is oxidatively dechlorinated in an NADPH- and O2-dependent reaction, resulting in the formation of acetaldehyde (AC).	Oxygen	50-52	apolipoprotein C4	Rattus norvegicus	0-3
8181453-6	1994	Glutathione peroxidase and glucose-6-phosphate dehydrogenase remained higher in lung tissue from oxygen-exposed animals from 6 through 12 days of hyperoxia.	Oxygen	97-103	glucose-6-phosphate dehydrogenase	Rattus norvegicus	27-60
8288528-0	1994	DcrA, a c-type heme-containing methyl-accepting protein from Desulfovibrio vulgaris Hildenborough, senses the oxygen concentration or redox potential of the environment.	Oxygen	110-116	dcrA	Desulfovibrio vulgaris str. Hildenborough	0-4
8288528-8	1994	L-[methyl-3H]methionine labeling of D. desulfuricans G200(pJRFR2) under different conditions indicated that methyl labeling of DcrA decreased upon addition of oxygen and increased upon subsequent addition of the reducing agent dithionite.	Oxygen	159-165	dcrA	Desulfovibrio vulgaris str. Hildenborough	127-131
8288528-9	1994	These results indicate that DcrA may serve as a sensor of oxygen concentration and/or redox potential.	Oxygen	58-64	dcrA	Desulfovibrio vulgaris str. Hildenborough	28-32
8242628-5	1993	A pentafluorinated derivative [EF5; 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetam ide] of etanidazole was synthesized with the expectation of lessening some of the non-oxygen-dependent variability in adduct formation observed previously with other nitroaromatic compounds.	Oxygen	189-195	angiogenin, ribonuclease A family, member 3	Mus musculus	31-34
31677055-0	2020	Vitexin, an inhibitor of hypoxia-inducible factor-1alpha, enhances the radiotherapy sensitization of hyperbaric oxygen on glioma.	Oxygen	112-118	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-56
8144352-0	1993	Hb Howick [beta 37(C3)Trp--&gt;Gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact.	Oxygen	48-54	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	87-93
31332679-5	2020	For model electroless plating solutions as adsorbate system possessing desired solution chemistry complexity and resin cost, nitrogen- and oxygen-containing Amberlyst A21 resin is concluded to be optimal resin.	Oxygen	139-145	immunoglobulin kappa variable 2-26 (pseudogene)	Homo sapiens	167-170
8253869-0	1993	Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism.	Oxygen	0-6	integrin subunit alpha L	Homo sapiens	79-84
32369776-0	2020	Oxygen therapy alleviates hepatic steatosis by inhibiting hypoxia-inducible factor-2alpha.	Oxygen	0-6	endothelial PAS domain protein 1	Mus musculus	58-89
8218368-4	1993	The PMA-induced decrease in the O2.- production may be related to the inactivation of NADPH-producing enzymes such as glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase that we have found with age.	Oxygen	32-34	glucose-6-phosphate dehydrogenase	Rattus norvegicus	118-151
32298772-12	2020	We further showed that decreased Crat expression in both MIN6B1 cells and pancreatic islets reduced oxygen consumption rate in a glucose concentration-dependent manner.	Oxygen	100-106	carnitine acetyltransferase	Mus musculus	33-37
33345056-7	2020	Sex differences in MET-values (men, 8.7; women 7.4) mirrored higher levels of cycling speed (20%), body weight (29%), oxygen uptake (54%) and ventilation (51%) in men compared to women.	Oxygen	118-124	SAFB like transcription modulator	Homo sapiens	19-22
32579210-0	2020	Expression of Concern: LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targetting miR-145.	Oxygen	141-147	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	30-36
32579210-0	2020	Expression of Concern: LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targetting miR-145.	Oxygen	141-147	microRNA 145	Homo sapiens	183-190
31980286-1	2020	BACKGROUND: To our knowledge, no study has assessed the correlation of fraction of inspired oxygen (FiO2) and end-tidal oxygen (EtO2) values obtained from a gas analyzer during the preoxygenation period of rapid sequence intubation (RSI) to predict partial pressure of oxygen (PaO2) among patients requiring intubation in the emergency department (ED).	Oxygen	120-126	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	128-132
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	147-150
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	147-150
8248161-4	1993	Analysis of potential NAD binding sites suggested a simple hypothesis for the conversion of human XD into the oxygen metabolite forming xanthine oxidase (XO; xanthine:oxygen oxidoreductase, EC 1.1.3.22).	Oxygen	110-116	xanthine dehydrogenase	Homo sapiens	98-100
32020230-3	2020	Myoglobin (MB), the oxygen-binding hemoprotein, has been shown to be ectopically expressed in different human cancers and cell lines, and its expression is hypothesized to be an adaptation mechanism to hypoxia.	Oxygen	20-26	myoglobin	Homo sapiens	0-9
32020230-3	2020	Myoglobin (MB), the oxygen-binding hemoprotein, has been shown to be ectopically expressed in different human cancers and cell lines, and its expression is hypothesized to be an adaptation mechanism to hypoxia.	Oxygen	20-26	myoglobin	Homo sapiens	11-13
32438803-0	2020	Oxygen Vacancy-Enhanced Electrochemiluminescence Sensing Strategy Using Luminol Thermally Encapsulated in Apoferritin as a Transducer for Biomarker Immunoassay.	Oxygen	0-6	ferritin heavy chain 1	Homo sapiens	106-117
32438803-1	2020	Oxygen vacancies (OVs) enhanced electrochemiluminescence (ECL) biosensing strategy using luminol thermally encapsulated in apoferritin (Lum@apoFt) as an efficient transducer was investigated for ultrasensitive biomarker detection.	Oxygen	0-6	ferritin heavy chain 1	Homo sapiens	123-134
32437172-7	2020	At low molar ratios (1 U:1 AAO/BAO and 1 U:2 AAO/BAO) the dominant species is the uranyl coordinated via the eta1-oxygen atom of the oxime group, while at high molar ratios (1 U:3 AAO/BAO and 1 U:4 AAO/BAO) the dominant species are a tetrameric uranyl-mu3-O-eta1-amidoxime complex similar to compounds 5 and 6 and a uranyl-eta2-amidoxime complex similar to compounds 3 and 4.	Oxygen	114-120	secreted phosphoprotein 1	Homo sapiens	109-113
8248161-4	1993	Analysis of potential NAD binding sites suggested a simple hypothesis for the conversion of human XD into the oxygen metabolite forming xanthine oxidase (XO; xanthine:oxygen oxidoreductase, EC 1.1.3.22).	Oxygen	110-116	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	174-188
32386004-12	2020	The reason of MET calls showed that abnormal pulse oxygen saturation [SpO2, 27.8% (235/846)] were the most among 4 vital signs.	Oxygen	51-57	SAFB like transcription modulator	Homo sapiens	14-17
8248161-6	1993	This RNA exhibited tissue-specific distribution that may be pertinent to XD- and XO-mediated oxygen radical injury in ischemia/reperfusion and inflammation.	Oxygen	93-99	xanthine dehydrogenase	Homo sapiens	73-75
8275502-1	1993	2,6-Dihydropyran-3-ones carrying substituents at C-2 and C-6 in cis-arrangement invariably adopt half-chair conformations in which the ring oxygen and the carbon atom next to the carbonyl group are above and below, respectively, the plane formed by the other four carbon atoms, i.e., the 2Ho or oH2 conformation.	Oxygen	140-146	complement C6	Homo sapiens	57-60
32076097-0	2020	Author Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism.	Oxygen	133-139	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	148-153
32532132-4	2020	The obtained data showed that the permeability of gas transport was strongly affected by: (i) the blend composition-it was observed that the increase in acrylonitrile butadiene rubber component considerably decreased the permeability; (ii) the nature of the gas-the permeation of CO2 was higher than O2; (iii) the nanoclay loading-it was found that the permeability decreased with the incorporation of nanoclay.	Oxygen	281-283	gastrin	Homo sapiens	50-53
32532132-4	2020	The obtained data showed that the permeability of gas transport was strongly affected by: (i) the blend composition-it was observed that the increase in acrylonitrile butadiene rubber component considerably decreased the permeability; (ii) the nature of the gas-the permeation of CO2 was higher than O2; (iii) the nanoclay loading-it was found that the permeability decreased with the incorporation of nanoclay.	Oxygen	281-283	gastrin	Homo sapiens	258-261
8409429-9	1993	Importantly, when the generation of alpha beta T cells in submersion culture was restored by elevating oxygen concentrations, there was a dramatic increase in TCF1(alpha) activity, and both NF-kappa B and NF-Y returned to control levels.	Oxygen	103-109	transcription factor 7, T cell specific	Mus musculus	159-169
32107312-8	2020	Of note, a relatively high Km for O2 suggested that O2 availability may regulate AspH activity in a biologically relevant manner.	Oxygen	34-36	aspartate beta-hydroxylase	Homo sapiens	81-85
32107312-8	2020	Of note, a relatively high Km for O2 suggested that O2 availability may regulate AspH activity in a biologically relevant manner.	Oxygen	52-54	aspartate beta-hydroxylase	Homo sapiens	81-85
32148597-0	2020	DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1.	Oxygen	70-76	FUN14 domain containing 1	Rattus norvegicus	92-98
32148597-2	2020	We investigated the role of hyperbaric oxygen (HBO) in expression of FUN14 domain-containing 1 (FUNDC1), which is associated with DNA methylation.	Oxygen	39-45	FUN14 domain containing 1	Rattus norvegicus	69-94
32148597-2	2020	We investigated the role of hyperbaric oxygen (HBO) in expression of FUN14 domain-containing 1 (FUNDC1), which is associated with DNA methylation.	Oxygen	39-45	FUN14 domain containing 1	Rattus norvegicus	96-102
32066777-0	2020	VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration.	Oxygen	70-76	vascular endothelial growth factor A	Rattus norvegicus	0-4
32118173-8	2020	The Li2CO3 and carbon reactants may improve rate capability by facilitating Li+ transport, and LiF may stabilize the Li2O2 (and/or LiO2) produced by the oxygen redox reaction with lithia.	Oxygen	153-159	LIF interleukin 6 family cytokine	Homo sapiens	95-98
32656187-5	2020	Resulting cellular profiles illustrate the effect of pericellular oxygen concentration and consumption rates on hepatic functionality in terms of zone-specific metabolism and beta-catenin signaling.	Oxygen	66-72	catenin beta 1	Rattus norvegicus	175-187
31990992-0	2020	Inhibition of microRNA-199a-5p ameliorates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO-1 signaling.	Oxygen	43-49	heme oxygenase 1	Homo sapiens	174-178
8104434-1	1993	The distribution of intercellular adhesion molecule-1 (ICAM-1) on alveolar epithelial cells and the effects of exposure to 100% O2 on ICAM-1 expression in mouse lungs were studied by EM immunocytochemistry and immunoblot analysis.	Oxygen	128-130	intercellular adhesion molecule 1	Mus musculus	134-140
31903559-1	2020	NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as autophagy dysregulation and increased reactive oxygen species production stimulating inflammation by priming the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 in their active form.	Oxygen	131-137	interleukin 18	Bos taurus	259-273
32213636-4	2020	We show that RPT2 suppresses the activity of phot1 and demonstrate that RPT2 binds to the PHOT1 LOV1 (light, oxygen or voltage sensing 1) domain which is required for its high photosensitivity.	Oxygen	109-115	Phototropic-responsive NPH3 family protein	Arabidopsis thaliana	13-17
32031575-0	2020	Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced Pathological Neovascularization in Murine Oxygen-Induced Retinopathy.	Oxygen	101-107	epithelial membrane protein 2	Mus musculus	0-29
32031575-0	2020	Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced Pathological Neovascularization in Murine Oxygen-Induced Retinopathy.	Oxygen	101-107	epithelial membrane protein 2	Mus musculus	31-35
32031575-4	2020	We, therefore, hypothesized that Emp2 knockout (Emp2 KO) protects against neovascularization in murine oxygen-induced retinopathy (OIR).	Oxygen	103-109	epithelial membrane protein 2	Mus musculus	33-37
32213636-4	2020	We show that RPT2 suppresses the activity of phot1 and demonstrate that RPT2 binds to the PHOT1 LOV1 (light, oxygen or voltage sensing 1) domain which is required for its high photosensitivity.	Oxygen	109-115	Phototropic-responsive NPH3 family protein	Arabidopsis thaliana	72-76
31916354-6	2020	Mechanistically, hyperglycaemia induces Smad4 localization to mitochondria in podocytes, resulting in reduced glycolysis and oxidative phosphorylation and increased production of reactive oxygen species.	Oxygen	188-194	SMAD family member 4	Mus musculus	40-45
8104434-6	1993	After exposure to O2, the labeling density of ICAM-1 on the central surface of type I epithelial cells was not changed significantly.	Oxygen	18-20	intercellular adhesion molecule 1	Mus musculus	46-52
8104435-5	1993	The purpose of this study was to examine the role of inflammation in hyperoxia-induced lung injury by investigating ICAM-1 expression in the lungs of mice exposed to &gt; 95% oxygen continuously.	Oxygen	175-181	intercellular adhesion molecule 1	Mus musculus	116-122
32452633-4	2020	Notably, for the first time, it is found that the in situ generated CoOOH during the oxygen evolution reaction (OER) can inherit the oxygen vacancies of pristine Co3 O4 (i.e., before OER), and such CoOOH with abundant oxygen vacancies adsorbs two - OH in the following Co3+ to Co4+ for markedly promoting OER.	Oxygen	85-91	complement C4A (Rodgers blood group)	Homo sapiens	277-280
7507440-5	1993	Replacement of sulphur by oxygen in the phosphorothioate diazinon reduced in vivo liver kynurenine formamidase inhibition.	Oxygen	26-32	arylformamidase	Mus musculus	88-110
32452633-4	2020	Notably, for the first time, it is found that the in situ generated CoOOH during the oxygen evolution reaction (OER) can inherit the oxygen vacancies of pristine Co3 O4 (i.e., before OER), and such CoOOH with abundant oxygen vacancies adsorbs two - OH in the following Co3+ to Co4+ for markedly promoting OER.	Oxygen	133-139	complement C4A (Rodgers blood group)	Homo sapiens	277-280
32452633-4	2020	Notably, for the first time, it is found that the in situ generated CoOOH during the oxygen evolution reaction (OER) can inherit the oxygen vacancies of pristine Co3 O4 (i.e., before OER), and such CoOOH with abundant oxygen vacancies adsorbs two - OH in the following Co3+ to Co4+ for markedly promoting OER.	Oxygen	133-139	complement C4A (Rodgers blood group)	Homo sapiens	277-280
32019549-10	2020	Research on the F-ATPase/Cav2.3 functional complex indicated that it can regulate extracellular Ca2+ influx, thereby modulating ERK1/2 phosphorylation and reactive oxygen species production, which are typical features of neutrophil activation.	Oxygen	164-170	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	25-31
31964807-9	2020	On one hand, Cops5 suppresses the autophagic degradation of Mtch2 to direct cellular metabolism toward glycolysis and minimize reactive oxygen species (ROS) production, thereby reducing endogenous DNA damage.	Oxygen	136-142	mitochondrial carrier 2	Homo sapiens	60-65
31929872-9	2020	Hg2+-upregulated MIP-2 expression was suppressed by NAC regardless of the time sequence of the treatment, suggesting that the suppressive role of NAC in Hg2+-induced inflammation manifests as a possible chelator and antioxidant/reactive oxygen species scavenger.	Oxygen	237-243	C-X-C motif chemokine ligand 2	Homo sapiens	17-22
32472050-8	2020	We suggest that an oxygen-sensitive RBP cluster controls anaerobic metabolism to confer hypoxia tolerance.	Oxygen	19-25	SURP and G-patch domain containing 1	Homo sapiens	36-39
8412126-6	1993	Interleukin-1 alpha (IL-1 alpha), transforming growth factor beta (TGF-beta), and tumor necrosis factor alpha (TNF alpha) stimulated phorbol ester-induced O2- production by resident macrophages in a concentration-dependent manner.	Oxygen	155-157	interleukin-1 alpha	Oryctolagus cuniculus	0-19
32434995-4	2020	Unbiased high-throughput metabolic profiling coupled with in vitro and in vivo flux analyses with isotopically labeled tracers led us to discover that maternal eENT1-dependent adenosine uptake is critical in activating AMPK by controlling the AMP/ATP ratio and its downstream target, bisphosphoglycerate mutase (BPGM); in turn, BPGM mediates 2,3-BPG production, which enhances O2 delivery to maintain placental oxygenation.	Oxygen	377-379	bisphosphoglycerate mutase	Homo sapiens	284-310
32434995-4	2020	Unbiased high-throughput metabolic profiling coupled with in vitro and in vivo flux analyses with isotopically labeled tracers led us to discover that maternal eENT1-dependent adenosine uptake is critical in activating AMPK by controlling the AMP/ATP ratio and its downstream target, bisphosphoglycerate mutase (BPGM); in turn, BPGM mediates 2,3-BPG production, which enhances O2 delivery to maintain placental oxygenation.	Oxygen	377-379	bisphosphoglycerate mutase	Homo sapiens	312-316
32434995-4	2020	Unbiased high-throughput metabolic profiling coupled with in vitro and in vivo flux analyses with isotopically labeled tracers led us to discover that maternal eENT1-dependent adenosine uptake is critical in activating AMPK by controlling the AMP/ATP ratio and its downstream target, bisphosphoglycerate mutase (BPGM); in turn, BPGM mediates 2,3-BPG production, which enhances O2 delivery to maintain placental oxygenation.	Oxygen	377-379	bisphosphoglycerate mutase	Homo sapiens	328-332
32434556-5	2020	Reducing Abeta and tau levels by combination of exercise and 40-Hz light flickering improves Ca2+ homeostasis and reactive oxygen species such as H2O2 in mitochondria and apoptosis including bax, bcl-2, cytochrome c, and cleaved caspase-3 and cell death, cell differentiation, and neurogenesis in the 3xTg-AD model of the hippocampus, resulting in improving cognitive impairment such as spatial learning, memory and long term memory.	Oxygen	123-129	amyloid beta (A4) precursor protein	Mus musculus	9-14
32514479-7	2020	On the other hand, myonectin significantly suppressed RANKL-induced oxygen consumption rate and peroxisome proliferator-activated receptor gamma coactivator-1beta mRNA levels in RAW264.7 cells, although myonectin did not affect these mitochondrial biogenesis parameters in mouse osteoblasts.	Oxygen	68-74	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	54-59
31596526-9	2020	Mechanistically, we identified the generation of reactive oxygen species and ATP as key events required for SOD1G93A -mediated NLRP3 activation.	Oxygen	58-64	NLR family, pyrin domain containing 3	Mus musculus	127-132
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	214-217	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	65-70
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	214-217	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	72-117
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	214-217	carbonic anhydrase 1	Rattus norvegicus	173-176
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	214-217	carbonic anhydrase 1	Rattus norvegicus	173-176
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	282-285	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	65-70
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	282-285	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	72-117
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	282-285	carbonic anhydrase 1	Rattus norvegicus	173-176
31865796-4	2020	We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Cai in THALs; these increases in Cai are necessary for stretch to augment O2- production; and stretch-stimulated, and therefore flow-induced, O2- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Cai.	Oxygen	282-285	carbonic anhydrase 1	Rattus norvegicus	173-176
31865796-13	2020	Conclusions are as follows: (1) stretch activates TRPV4, which raises Cai in THALs; (2) the increase in Cai stimulates O2- production; and (3) stretch-induced O2- production is enhanced in SS THALs due to greater increases in Cai.	Oxygen	119-122	carbonic anhydrase 1	Rattus norvegicus	104-107
31865796-13	2020	Conclusions are as follows: (1) stretch activates TRPV4, which raises Cai in THALs; (2) the increase in Cai stimulates O2- production; and (3) stretch-induced O2- production is enhanced in SS THALs due to greater increases in Cai.	Oxygen	119-122	carbonic anhydrase 1	Rattus norvegicus	104-107
31865796-13	2020	Conclusions are as follows: (1) stretch activates TRPV4, which raises Cai in THALs; (2) the increase in Cai stimulates O2- production; and (3) stretch-induced O2- production is enhanced in SS THALs due to greater increases in Cai.	Oxygen	159-162	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	50-55
32509491-3	2020	CTF-1-600 and Ni/CTF-1-600 show high catalytic activity towards OER and a clear activity for the electrochemical oxygen reduction reaction (ORR).	Oxygen	113-119	cardiotrophin 1	Homo sapiens	0-5
32455182-6	2020	During water oxidation catalysis, NiO x -SC/FTO initiates the oxygen evolution reaction (OER) at an overpotential eta of just 250 mV while generating current decade at just 300 mV and demonstrates well-balanced kinetics toward OER.	Oxygen	62-68	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	44-47
31865796-13	2020	Conclusions are as follows: (1) stretch activates TRPV4, which raises Cai in THALs; (2) the increase in Cai stimulates O2- production; and (3) stretch-induced O2- production is enhanced in SS THALs due to greater increases in Cai.	Oxygen	159-162	carbonic anhydrase 1	Rattus norvegicus	104-107
8412126-6	1993	Interleukin-1 alpha (IL-1 alpha), transforming growth factor beta (TGF-beta), and tumor necrosis factor alpha (TNF alpha) stimulated phorbol ester-induced O2- production by resident macrophages in a concentration-dependent manner.	Oxygen	155-157	interleukin-1 alpha	Oryctolagus cuniculus	21-31
8367458-2	1993	Saccharomyces cerevisiae strains lacking copper-zinc superoxide dismutase, which is encoded by the SOD1 gene, are sensitive to oxidative stress and exhibit a variety of growth defects including hypersensitivity to dioxygen and to superoxide-generating drugs such as paraquat.	Oxygen	214-222	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	99-103
31875928-4	2020	In addition to DNA strand breaks, ATM and ATR also respond to oxidative DNA damage and reactive oxygen species (ROS), suggesting an unconventional function as regulators of intracellular redox status.	Oxygen	96-102	ATM serine/threonine kinase	Homo sapiens	34-37
31645630-5	2020	In lung injury, TRPV4 mediates macrophage phagocytosis, secretion of pro-resolution cytokines, and generation of reactive oxygen species.	Oxygen	122-128	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	16-21
31772327-5	2020	Mechanistically, ABCB7 mitigates non-apoptotic cell death by reducing levels of mitochondrial reactive oxygen species.	Oxygen	103-109	ATP binding cassette subfamily B member 7	Homo sapiens	17-22
32375802-2	2020	Malignant cells can undergo genetic and adaptive changes that prevent them from dying due to oxygen deprivation through expressions of hypoxia-inducible factor 1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	Oxygen	93-99	vascular endothelial growth factor A	Felis catus	185-219
32375802-2	2020	Malignant cells can undergo genetic and adaptive changes that prevent them from dying due to oxygen deprivation through expressions of hypoxia-inducible factor 1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	Oxygen	93-99	vascular endothelial growth factor A	Felis catus	221-225
32106033-3	2020	The methyl substituent on the third position of the piperidine ring takes up a syn-periplanar positioning although the chloro substituent takes up an anti-clinical positioning with dihedral angle: Cl1-C2-C1-O1 = 113.3 (2 ) due to the repulsion from an adjacent oxygen atom.	Oxygen	261-267	adhesion G protein-coupled receptor L1	Homo sapiens	197-200
32366855-4	2020	Extracellular flow assays showed that TPL inhibited cellular basal and maximal oxygen consumption rates of mitochondrial.	Oxygen	79-85	BPI fold containing family A, member 5	Mus musculus	38-41
8367458-4	1993	We demonstrate here that expression of the yeast or monkey metallothionein proteins in the presence of copper suppresses the lactate growth defect and some other phenotypes associated with SOD1-deletion strains, indicating that copper metallothioneins substitute for copper-zinc superoxide dismutase in vivo to protect cells from oxygen toxicity.	Oxygen	330-336	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	189-193
31814336-3	2020	METHODS: We used immunofluorescence to detect the expression of Sphk1 and NOS in cerebral epithelial cells (EC) after IR or oxygen-glucose deprivation (OGDR).	Oxygen	124-130	sphingosine kinase 1	Homo sapiens	64-69
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Oxygen	144-150	endothelin receptor type A	Homo sapiens	140-143
31939276-5	2020	Using a galectin-8 recruitment assay, we showed that reactive oxygen species generated by ICG upon light irradiation functioned as an endosomolytic stimulus that caused release of the siRNA/miRNA combination from endosomes.	Oxygen	62-68	galectin 8	Homo sapiens	8-18
8339636-1	1993	The effects of oxygen therapy in patients with stable COPD have been previously reported; however, the hemodynamic changes induced by oxygen therapy in patients during acute exacerbations of COPD are less well known.	Oxygen	15-21	COPD	Homo sapiens	54-58
31870154-2	2020	This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.	Oxygen	9-17	indoleamine 2,3-dioxygenase 1	Homo sapiens	149-176
31870154-2	2020	This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.	Oxygen	9-17	indoleamine 2,3-dioxygenase 1	Homo sapiens	178-181
31978092-8	2020	Increased generation of reactive oxygen species (ROS) coupled with increased expression of p53 may be the mechanism(s) underlying pro-apoptotic action of ACAT-1 inhibition.	Oxygen	33-39	acetyl-CoA acetyltransferase 1	Homo sapiens	154-160
31868193-6	2020	These FA-H@NDs assisted by US irradiation can also induce the production of excess reactive oxygen species (ROS) and consequently trigger tumor cell/tissue apoptosis and necrosis.	Oxygen	92-98	fumarylacetoacetate hydrolase	Homo sapiens	6-10
31963721-10	2020	As a consequence, the free thiol of monomeric Tff1 could have a protective scavenger function, e.g., for reactive oxygen/nitrogen species.	Oxygen	114-120	trefoil factor 1	Mus musculus	46-50
31782272-6	2020	We also used small interfering RNAs (siRNAs) to abrogate the expression of mTOR in 90% O2 exposed L929 cells, and then evaluated the apoptosis and cell viability using flow cytometry and the MTT assay, respectively.	Oxygen	87-89	mechanistic target of rapamycin kinase	Mus musculus	75-79
32985231-7	2020	Finally, oxygen and glucose deprivation reduced GFAP expression and the colocalization and molecular association of GFAP with aquaporin 4 in the SON in brain slices.	Oxygen	9-15	aquaporin 4	Rattus norvegicus	126-137
32114569-2	2020	Myoglobin is an iron and oxygen-binding protein that is freely filtered by the glomerulus.	Oxygen	25-31	myoglobin	Homo sapiens	0-9
31790952-1	2020	Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner.	Oxygen	134-140	receptor interacting serine/threonine kinase 1	Homo sapiens	175-180
32738735-7	2020	Cardiac differentiation in 5% instead of 20% oxygen resulted in reduced development of spontaneously beating cardiomyocytes and lower expression of cardiac markers Nkx2.5, Myh6 and MF20 (myosin), regardless whether ESC had been cultured in 5% or 20% oxygen tension.	Oxygen	45-51	myosin heavy chain 14	Homo sapiens	187-193
31735085-6	2020	Mechanistically, vildagliptin-activated Transient Receptor Potential Channel Vanilloid 4 (TRPV4) to promote extracellular calcium uptake in endothelial cells, which activated AMPK (AMP-activated protein kinase)/SIRT1 pathway to counteract hyperglycemia-induced endothelial reactive oxygen species generation and senescence.	Oxygen	282-288	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	40-88
31735085-6	2020	Mechanistically, vildagliptin-activated Transient Receptor Potential Channel Vanilloid 4 (TRPV4) to promote extracellular calcium uptake in endothelial cells, which activated AMPK (AMP-activated protein kinase)/SIRT1 pathway to counteract hyperglycemia-induced endothelial reactive oxygen species generation and senescence.	Oxygen	282-288	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	90-95
31921483-3	2020	Hypoxia-inducible factor (HIF)-1alpha is pivotal in the transcriptional response to the oxygen flux.	Oxygen	88-94	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
31955159-4	2020	OBJECTIVE: In the present study, we used a mouse model of oxygen-induced retinopathy (OIR) to demonstrate the effects of the HIF-1alpha inhibitor PX-478 on OIR, and to determine its mechanism of action, to provide a theoretical basis for the clinical treatment of ROP.	Oxygen	58-64	hypoxia inducible factor 1, alpha subunit	Mus musculus	125-135
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	DNA-damage inducible transcript 3	Mus musculus	272-296
31639651-5	2020	We found that exposing HT-22 cells to oxygen-glucose deprivation (OGD) significantly activated ER stress, as evidenced by increased expression of the 78-kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic translation-initiation factor 2alpha (eIF2alpha), and C/EBP-homologous protein (CHOP).	Oxygen	38-44	DNA-damage inducible transcript 3	Mus musculus	298-302
31581069-1	2020	Mice deficient in glucose-6-phosphate dehydrogenase (G6PD) cannot replenish the cellular antioxidant glutathione, which detoxifies neurodegenerative reactive oxygen species (ROS).	Oxygen	158-164	glucose-6-phosphate dehydrogenase 2	Mus musculus	18-51
31581069-1	2020	Mice deficient in glucose-6-phosphate dehydrogenase (G6PD) cannot replenish the cellular antioxidant glutathione, which detoxifies neurodegenerative reactive oxygen species (ROS).	Oxygen	158-164	glucose-6-phosphate dehydrogenase 2	Mus musculus	53-57
31706564-2	2020	However, the relation among iron and oxygen in this population is far from understood as hepcidin is generally upregulated, potentially avoiding iron availability and harm in the context of excess oxidative stress.	Oxygen	37-43	hepcidin antimicrobial peptide	Homo sapiens	89-97
31760267-2	2020	We previously identified anti-TNFalpha-induced apoptosis (ATIA, also known as vasorin) as an antiapoptotic factor that suppresses reactive oxygen species (ROS) production.	Oxygen	139-145	vasorin	Homo sapiens	78-85
31810001-7	2020	HO-1 attenuated reactive oxygen species induced by H2O2 or pyocyanin treatment in PC-3 and DU145 cells.	Oxygen	25-31	heme oxygenase 1	Homo sapiens	0-4
31905813-1	2019	BACKGROUND: The present study was designed to explore the underlying role of hypoxia-inducible factor 1alpha (HIF-1alpha) in reactive oxygen species (ROS) formation and apoptosis in osteosarcoma (OS) cells induced by hypoxia.	Oxygen	134-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	77-108
31905813-1	2019	BACKGROUND: The present study was designed to explore the underlying role of hypoxia-inducible factor 1alpha (HIF-1alpha) in reactive oxygen species (ROS) formation and apoptosis in osteosarcoma (OS) cells induced by hypoxia.	Oxygen	134-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	110-120
31825469-5	2019	CyPA from blood vessels and the heart itself participates in a variety of signaling pathways to regulate the production of reactive oxygen species (ROS) and mediate inflammation, promote cardiomyocyte hypertrophy and proliferation of cardiac fibroblasts, stimulate endothelial injury and vascular smooth muscle hyperplasia, and promote the dissolution of extracellular matrix (ECM) by activating matrix metalloproteinases (MMPs).	Oxygen	132-138	peptidylprolyl isomerase A	Homo sapiens	0-4
31751119-5	2019	We demonstrated that RT plus tumor-targeting delivery of oxygen mediated by Hb-Lipo could significantly overcome the tolerance of hypoxic cancer cells to RT, showing significantly enhanced cancer cells killing and tumor growth inhibition ability, mainly attributing to hypoxia alleviation and increased ROS production under RT in cancer cells.	Oxygen	57-63	high mobility group AT-hook 2	Homo sapiens	79-83
31751119-8	2019	However, extremely strong tumor inhibition could be obtained by RT combined with DOX-Hb-Lipo-mediated CT, attributing to radio-triggered DOX release and an enhanced immunogenic cell death induced by RT under oxygen supplement.	Oxygen	208-214	high mobility group AT-hook 2	Homo sapiens	88-92
31949877-6	2019	Additionally, BLM- and TGF-beta1-evoked cellular reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, and cell apoptosis were rescued by MenSCs-Exo in vivo and in vitro.	Oxygen	58-64	5'-3' exoribonuclease 1	Mus musculus	156-159
32467610-5	2020	In vitro, both hypoxia (1% O2) and overexpression of HIF-1alpha reduced the protein level of RCAN1.4 in rat NP cells in a dose- and time-dependent manner.	Oxygen	27-29	regulator of calcineurin 1	Rattus norvegicus	93-98
32525819-0	2020	MicroRNA-19a mediates neuroprotection through the PTEN/AKT pathway in SK-N-SH cells after oxygen-glucose deprivation/reoxygenation injury.	Oxygen	90-96	microRNA 19a	Homo sapiens	0-12
32525819-0	2020	MicroRNA-19a mediates neuroprotection through the PTEN/AKT pathway in SK-N-SH cells after oxygen-glucose deprivation/reoxygenation injury.	Oxygen	90-96	phosphatase and tensin homolog	Homo sapiens	50-54
32239976-3	2020	Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen).Results: The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia.Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.	Oxygen	90-96	endoplasmic reticulum aminopeptidase 1	Homo sapiens	139-144
32172452-1	2020	Myoglobin (Mb), generally taken as the molecular model of monomeric globular heme-proteins, is devoted: (i) to act as an intracellular oxygen reservoir, (ii) to transport oxygen from the sarcolemma to the mitochondria of vertebrate heart and red muscle cells, and (iii) to act as a scavenger of nitrogen and oxygen reactive species protecting mitochondrial respiration.	Oxygen	135-141	myoglobin	Homo sapiens	0-9
32172452-1	2020	Myoglobin (Mb), generally taken as the molecular model of monomeric globular heme-proteins, is devoted: (i) to act as an intracellular oxygen reservoir, (ii) to transport oxygen from the sarcolemma to the mitochondria of vertebrate heart and red muscle cells, and (iii) to act as a scavenger of nitrogen and oxygen reactive species protecting mitochondrial respiration.	Oxygen	171-177	myoglobin	Homo sapiens	0-9
32411155-7	2020	The activation of GCN2 was accompanied by a more oxidative environment and was attenuated by inhibitors of photosynthetic electron transport, suggesting that it is gated by the redox poise or the reactive oxygen status of the chloroplast.	Oxygen	205-211	protein kinase family protein	Arabidopsis thaliana	18-22
32266903-3	2020	The results show that the PC3 monolayer is dynamically stable and robust upon oxygen contact as well.	Oxygen	78-84	chromobox 8	Homo sapiens	26-29
31657228-1	2020	SIGNIFICANCE: Most brains affected by neurodegenerative diseases manifest mitochondrial dysfunction as well as elevated production of reactive oxygen and nitrogen species (ROS/RNS), contributing to synapse loss and neuronal injury.	Oxygen	143-149	FAM20C golgi associated secretory pathway kinase	Homo sapiens	176-179
32233409-3	2020	Substitution of Gd3+ by Ca2+ increases the oxygen deficiency that is accommodated by the formation of layers of FeO5-squared pyramids intercalated with A-O layers containing mainly Gd3+.	Oxygen	43-49	GRDX	Homo sapiens	16-19
32233409-3	2020	Substitution of Gd3+ by Ca2+ increases the oxygen deficiency that is accommodated by the formation of layers of FeO5-squared pyramids intercalated with A-O layers containing mainly Gd3+.	Oxygen	43-49	GRDX	Homo sapiens	181-184
32070517-5	2020	The immunomodulatory assay suggested that MOP-3 could significantly enhance pinocytic capacity and increase the secretion of reactive oxygen species (ROS), nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) by up-regulating the corresponding mRNA expression levels in RAW 264.7 cells.	Oxygen	134-140	morphine preference 3	Mus musculus	42-47
32478642-3	2020	This can be overcome by using oxyhydrogen, which is a mixture of hydrogen and oxygen gas.	Oxygen	78-84	gastrin	Homo sapiens	85-88
31945508-4	2020	The AMH nanoparticles can generate abundant oxygen from mild acidic/H2O2 medium, which can further enhance the PDT efficacy of AMH itself under near infrared (NIR) irradiation.	Oxygen	44-50	anti-Mullerian hormone	Homo sapiens	4-7
31945508-4	2020	The AMH nanoparticles can generate abundant oxygen from mild acidic/H2O2 medium, which can further enhance the PDT efficacy of AMH itself under near infrared (NIR) irradiation.	Oxygen	44-50	anti-Mullerian hormone	Homo sapiens	127-130
31945508-6	2020	In vivo experiment results exhibited that AMH nanoparticles not only had the ability of targeting tumor but also in situ produced sufficient oxygen to relieve the tumor hypoxia.	Oxygen	141-147	anti-Mullerian hormone	Homo sapiens	42-45
31945508-7	2020	Furthermore, AMH-mediated oxygen-boosted immunogenic PDT effectively inhibited the tumor growth and recurrence.	Oxygen	26-32	anti-Mullerian hormone	Homo sapiens	13-16
31945508-11	2020	AMH nanoparticle exhibits a good tumor-targeted ability to in situ produce abundant oxygen to relieve the tumor hypoxia, and initiates the potent oxygen-boosted immunogenic PDT effect under NIR irradiation to effectively inhibit the growth and recurrence of colorectal tumor.	Oxygen	84-90	anti-Mullerian hormone	Homo sapiens	0-3
31945508-11	2020	AMH nanoparticle exhibits a good tumor-targeted ability to in situ produce abundant oxygen to relieve the tumor hypoxia, and initiates the potent oxygen-boosted immunogenic PDT effect under NIR irradiation to effectively inhibit the growth and recurrence of colorectal tumor.	Oxygen	146-152	anti-Mullerian hormone	Homo sapiens	0-3
31996026-2	2020	In hypoxic and cancer cells, HIF-1alpha (hypoxia-inducible factor) promotes oxygen-independent energy production by microRNAs.	Oxygen	76-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	29-39
31996026-5	2020	In inflammatory bone marrow-derived macrophages, deletion of Hif1a increased oxidative phosphorylation, ATP levels, and the expression of genes encoding mitochondrial proteins and reduced reactive oxygen species production and necroptosis.	Oxygen	197-203	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-66
32127406-1	2020	The Von Hippel-Lindau gene product is a tumor suppressor whose ubiquitin ligase function is key to oxygen-sensing in cells, whereas Tank-binding kinase (TBK1) is a kinase mostly implicated in innate immune response.	Oxygen	99-105	TANK binding kinase 1	Homo sapiens	153-157
32020679-7	2020	In adulthood, maternal MFGM-PL supplementation reduced adiposity and increased oxygen consumption, respiratory exchange ratio, and heat production in male offspring.	Oxygen	79-85	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	23-27
31873747-5	2020	We further found that respiratory activity, as measured by oxygen consumption rates, was severely repressed in Drp1-deficient HeLa cells and that this was reversible by the co-repression of mitochondrial fusion factors.	Oxygen	59-65	dynamin 1 like	Homo sapiens	111-115
30834805-7	2020	In vitro studies confirmed that 5 or 10 ng/mL TGFalpha directly protected OPCs and oligodendrocytes against oxygen and glucose deprivation (OGD)-induced cell death, but exerted no effects on OPC differentiation.	Oxygen	108-114	transforming growth factor alpha	Mus musculus	46-54
31517390-10	2020	In the OGD model, overexpression of miR-31 and silencing of PKD1 attenuated oxidative stress-induced neuronal injury, and diminished the lactate dehydrogenase leakage and reactive oxygen species level, accompanied by elevated neuronal viability.	Oxygen	180-186	microRNA 31	Mus musculus	36-42
31980286-1	2020	BACKGROUND: To our knowledge, no study has assessed the correlation of fraction of inspired oxygen (FiO2) and end-tidal oxygen (EtO2) values obtained from a gas analyzer during the preoxygenation period of rapid sequence intubation (RSI) to predict partial pressure of oxygen (PaO2) among patients requiring intubation in the emergency department (ED).	Oxygen	120-126	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	128-132
31813325-0	2020	Hyperbaric oxygen suppresses stemness-associated properties and Nanog and oncostatin M expression, but upregulates beta-catenin in orthotopic glioma models.	Oxygen	11-17	catenin beta 1	Homo sapiens	115-127
31972206-7	2020	Mechanistically, Hed attenuated RANKL-induced intracellular reactive oxygen species (ROS) production, and MAPK signaling pathway (ERK and p38) activation which curbed the downstream induction of c-Fos and NFATc1.	Oxygen	69-75	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	32-37
31933109-3	2020	They are substrates for production of pyrroline-5-carboxylate which is the product of conversion of proline by proline dehydrogenase/ proline oxidase (PRODH/POX) to produce ATP for protective autophagy or reactive oxygen species for apoptosis.	Oxygen	214-220	proline dehydrogenase 1	Homo sapiens	151-156
31933109-3	2020	They are substrates for production of pyrroline-5-carboxylate which is the product of conversion of proline by proline dehydrogenase/ proline oxidase (PRODH/POX) to produce ATP for protective autophagy or reactive oxygen species for apoptosis.	Oxygen	214-220	proline dehydrogenase 1	Homo sapiens	157-160
31978708-0	2020	Corrigendum to "Galectin-1 modulation of neutrophil reactive oxygen species production depends on the cell activation state" [Mol.	Oxygen	61-67	galectin 1	Homo sapiens	16-26
31571659-0	2020	Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway.	Oxygen	37-43	serine/threonine kinase 11	Rattus norvegicus	104-108
31907278-3	2020	The oxygen-labile HIF-2alpha subunit has not only been implicated in transcription, but also as a regulator of eIF4E2-directed hypoxic translation.	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	18-28
31907278-3	2020	The oxygen-labile HIF-2alpha subunit has not only been implicated in transcription, but also as a regulator of eIF4E2-directed hypoxic translation.	Oxygen	4-10	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	111-117
31842349-9	2019	The reactive oxygen species (ROS) scavengers N-acetyl cysteine (NAC) and reduced glutathione (GSH) partially attenuated apoptosis in the HCT116 p53-/- cell line but had no obvious effect on the p53+/+ cell line.	Oxygen	13-19	transformation related protein 53, pseudogene	Mus musculus	144-147
31911858-8	2019	AKR1B10 overexpression reduced hepatocyte injury while AKR1B10 knockdown augmented reactive oxygen species (ROS) accumulation and apoptotic cell death.	Oxygen	92-98	aldo-keto reductase family 1, member B10 (aldose reductase)	Mus musculus	55-62
31674811-3	2019	We determined whether RIalpha is actively involved in the regulation of PKA activity via Reactive Oxygen Species (ROS) dependent mechanisms during I/R stress in the heart.	Oxygen	98-104	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	22-29
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	C-type lectin domain family 4 member D	Homo sapiens	349-355
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	C-type lectin domain family 4 member D	Homo sapiens	349-355
31823095-0	2019	LncRNA MALAT1 Promotes Oxygen-Glucose Deprivation and Reoxygenation Induced Cardiomyocytes Injury Through Sponging miR-20b to Enhance beclin1-Mediated Autophagy.	Oxygen	23-29	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	7-13
31634721-9	2019	The reactive oxygen species (ROS) levels in rIL-17A primed cells showed significant elevations in all groups.	Oxygen	13-19	interleukin 17A	Rattus norvegicus	44-51
31512297-10	2019	The difference (Delta) between the tau V  O 2 p     and MRT-TOI was greater during U   VH compared to U   M (12 +- 7 vs. 2 +- 7 s, P < 0.001) and during M   VH (23 +- 15 s) compared to other conditions (P < 0.02), suggesting an increased proportional speeding of fractional O2 extraction.	Oxygen	274-276	microtubule associated protein tau	Homo sapiens	35-38
31904544-4	2020	Using a HeLa cell line stably transfected with an inducible shRNA directed against Lon, we have previously observed that Lon depletion results in a mild phenotype characterized by an increase of both production of reactive oxygen species and level of oxidized proteins (Bayot et al., 2014, Biochimie, 100: 38-47).	Oxygen	223-229	lon peptidase 1, mitochondrial	Homo sapiens	83-86
31904544-4	2020	Using a HeLa cell line stably transfected with an inducible shRNA directed against Lon, we have previously observed that Lon depletion results in a mild phenotype characterized by an increase of both production of reactive oxygen species and level of oxidized proteins (Bayot et al., 2014, Biochimie, 100: 38-47).	Oxygen	223-229	lon peptidase 1, mitochondrial	Homo sapiens	121-124
31915259-9	2020	Continuous ligation of LILRB3 inhibited key IgA-mediated effector functions, including production of reactive oxygen species, phagocytic uptake, and microbial killing.	Oxygen	110-116	leukocyte immunoglobulin like receptor B3	Homo sapiens	23-29
8339636-1	1993	The effects of oxygen therapy in patients with stable COPD have been previously reported; however, the hemodynamic changes induced by oxygen therapy in patients during acute exacerbations of COPD are less well known.	Oxygen	134-140	COPD	Homo sapiens	191-195
31952989-7	2020	Aifm2 in BAT and subcutaneous white adipose tissue (WAT) promotes oxygen consumption, uncoupled respiration, and heat production during cold- and diet-induced thermogenesis.	Oxygen	66-72	apoptosis inducing factor mitochondria associated 2	Homo sapiens	0-5
8339636-2	1993	To investigate the hemodynamic effects of controlled oxygen therapy in patients with acute exacerbations of COPD shortly after arriving at the hospital, we studied 15 consecutive patients who came to the emergency room with acutely decompensated COPD that did not require mechanical ventilation.	Oxygen	53-59	COPD	Homo sapiens	108-112
31894125-0	2019	Isoflurane preconditioning protects hepatocytes from oxygen glucose deprivation injury by regulating FoxO6.	Oxygen	53-59	forkhead box O6	Homo sapiens	101-106
8339636-13	1993	We conclude that oxygen therapy in patients with acute exacerbations of COPD that do not require mechanical ventilation increases oxygen delivery without changes in cardiac output or oxygen uptake.	Oxygen	17-23	COPD	Homo sapiens	72-76
31894125-4	2019	In this study, we explored the role and mechanism of FoxO6 in the protective effect of isoflurane preconditioning during hepatocyte injury caused by oxygen-glucose deprivation (OGD).	Oxygen	149-155	forkhead box O6	Homo sapiens	53-58
31894125-7	2019	FoxO6 overexpression abolished the effects of 3% isoflurane preconditioning on caspase-3 activity, reactive oxygen species production, and cell viability in these cells.	Oxygen	108-114	forkhead box O6	Homo sapiens	0-5
31825806-7	2020	Our results suggest that cytochrome b5 reductase could contribute to the measured energetic failure in the erythrocyte apoptosis induced by juglone, that is concomitant with the reactive oxygen species produced by cytochrome b5 reductase.	Oxygen	187-193	cytochrome b5 type A	Homo sapiens	25-38
31825806-7	2020	Our results suggest that cytochrome b5 reductase could contribute to the measured energetic failure in the erythrocyte apoptosis induced by juglone, that is concomitant with the reactive oxygen species produced by cytochrome b5 reductase.	Oxygen	187-193	cytochrome b5 type A	Homo sapiens	214-227
8339636-13	1993	We conclude that oxygen therapy in patients with acute exacerbations of COPD that do not require mechanical ventilation increases oxygen delivery without changes in cardiac output or oxygen uptake.	Oxygen	130-136	COPD	Homo sapiens	72-76
8339636-13	1993	We conclude that oxygen therapy in patients with acute exacerbations of COPD that do not require mechanical ventilation increases oxygen delivery without changes in cardiac output or oxygen uptake.	Oxygen	130-136	COPD	Homo sapiens	72-76
8347143-7	1993	In conclusion, these results suggest an important role for iron in porphyrin accumulation, probably through its catalytic role in the generation of oxygen-related free radicals, resulting in direct damage to URO-D.	Oxygen	148-154	uroporphyrinogen decarboxylase	Mus musculus	208-213
31311728-0	2020	Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Insulin-Dependent Diabetes Mellitus Patients: A Pilot Study.	Oxygen	21-27	insulin like growth factor binding protein 1	Homo sapiens	66-110
31862654-0	2020	Downregulation of TRIM8 protects neurons from oxygen-glucose deprivation/re-oxygenation-induced injury through reinforcement of the AMPK/Nrf2/ARE antioxidant signaling pathway.	Oxygen	46-52	tripartite motif containing 8	Homo sapiens	18-23
31862654-3	2020	In the present study, we aimed to investigate the potential function and molecular mechanism of TRIM8 in regulating neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/re-oxygenation (OGD/R) in an in vitro model to study cerebral ischemia/reperfusion injury.	Oxygen	167-181	tripartite motif containing 8	Homo sapiens	96-101
31862654-5	2020	Knockdown of TRIM8 improved the viability and decreased the apoptosis and reactive oxygen species (ROS) generation in OGD/R-exposed neurons, whereas TRIM8 overexpression showed the opposite effect.	Oxygen	83-89	tripartite motif containing 8	Homo sapiens	13-18
31653515-7	2019	Univariate and multivariate regression analyses showed that changes in serum M2BP concentrations during the follow-up period were significantly associated with changes in low-density lipoprotein cholesterol (LDL-C), triglyceride, and oxidative stress marker derivatives of reactive oxygen metabolites (d-ROM) concentrations.	Oxygen	282-288	galectin 3 binding protein	Homo sapiens	77-81
30601332-2	2019	Hypoxia-inducible factor (HIF)-1alpha is a major transcription factor responsible for regulating the cellular response to changes in oxygen tension.	Oxygen	133-139	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
8369428-9	1993	We conclude that (a) the ratio NADH/NAD is decreased in well-oxygenated cells with increased work; (b) steady-state NAD reduction is increased with increased work when oxygen delivery is limited; and (c) functional myoglobin ensures an oxygen supply to the mitochondria of working cells.	Oxygen	168-174	myoglobin	Rattus norvegicus	215-224
31799068-12	2019	Overexpression of MEG3 attenuated HG-induced podocyte injury by reducing Wnt/beta-catenin activity, repressing cell migration, reactive oxygen species production and increasing the viability of podocytes.	Oxygen	136-142	maternally expressed 3	Homo sapiens	18-22
31837324-0	2020	LncRNA KCNQ1OT1 contributes to oxygen-glucose-deprivation/reoxygenation-induced injury via sponging miR-9 in cultured neurons to regulate MMP8.	Oxygen	31-37	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	7-15
31837324-0	2020	LncRNA KCNQ1OT1 contributes to oxygen-glucose-deprivation/reoxygenation-induced injury via sponging miR-9 in cultured neurons to regulate MMP8.	Oxygen	31-37	matrix metallopeptidase 8	Homo sapiens	138-142
8452566-10	1993	The absence of oxygen or a decreased cellular ATP content blocked the hepatocellular uptake of the renin inhibitor.	Oxygen	15-21	renin	Rattus norvegicus	99-104
31865796-13	2020	Conclusions are as follows: (1) stretch activates TRPV4, which raises Cai in THALs; (2) the increase in Cai stimulates O2- production; and (3) stretch-induced O2- production is enhanced in SS THALs due to greater increases in Cai.	Oxygen	159-162	carbonic anhydrase 1	Rattus norvegicus	104-107
31876943-2	2020	The characteristic phenotype and known genetic cause of the syndrome provide an opportunity to study the role of hypoxia-inducible factor 2alpha (HIF-2alpha) in oxygen sensing, development in regions of physiologic hypoxia, and other pathological processes.	Oxygen	161-167	endothelial PAS domain protein 1	Homo sapiens	113-144
31876943-2	2020	The characteristic phenotype and known genetic cause of the syndrome provide an opportunity to study the role of hypoxia-inducible factor 2alpha (HIF-2alpha) in oxygen sensing, development in regions of physiologic hypoxia, and other pathological processes.	Oxygen	161-167	endothelial PAS domain protein 1	Homo sapiens	146-156
32019183-9	2020	Furthermore, we found that loss of Bmal1 was associated with the accumulation of Reactive Oxygen Species Modulator 1 (ROMO1), a protein responsible for inducing the production of intracellular reactive oxygen species (ROS).	Oxygen	202-208	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	35-40
32476374-4	2020	Then PC12 cells and SH-SY5Y cells were co-treated with CeO2 and active oxygen scavenger NAC and the cells were stained with DCFH-DA probe for ROS.	Oxygen	71-77	synuclein alpha	Homo sapiens	88-91
32476374-9	2020	The fluorescence intensity of PC12 cells was decreased after CeO2 nanoparticles (100 mug/ml) co-treatment with active oxygen scavenger NAC.	Oxygen	118-124	synuclein alpha	Homo sapiens	135-138
31799454-0	2020	Control of doxorubicin-induced, reactive oxygen-related apoptosis by glutathione peroxidase 1 in cardiac fibroblasts.	Oxygen	41-47	glutathione peroxidase 1	Mus musculus	69-93
31799454-8	2020	Reactive oxygen levels in homozygous Gpx-1 knockout fibroblasts, irrespective of selenium supplementation status, were increased and equivalent to that in selenium deficient wild type fibroblasts.	Oxygen	9-15	glutathione peroxidase 1	Mus musculus	37-42
31670933-7	2019	Positive correlation between MSAg to MSAT ratios and temperature were presented, when the temperature was higher than 5 oC.	Oxygen	120-122	anaphase promoting complex subunit 16	Homo sapiens	29-33
31752220-4	2019	Analysis using flow cytometry revealed that COX20 expression was associated with reduced levels of reactive oxygen species (ROS) in hydrogen peroxide and metal-induced stress, and there was a reduction in apoptotic and necrotic cells when compared with a strain without COX20.	Oxygen	108-114	Cox20p	Saccharomyces cerevisiae S288C	44-49
31752220-4	2019	Analysis using flow cytometry revealed that COX20 expression was associated with reduced levels of reactive oxygen species (ROS) in hydrogen peroxide and metal-induced stress, and there was a reduction in apoptotic and necrotic cells when compared with a strain without COX20.	Oxygen	108-114	Cox20p	Saccharomyces cerevisiae S288C	270-275
31635453-2	2019	The methodology is mild and eco-friendly, proceeds in the presence of air or molecular oxygen (1 atm) as the sole sacrificial reagent, and generates water as the only byproduct.	Oxygen	87-93	ATM serine/threonine kinase	Homo sapiens	97-100
7763472-1	1993	The effect of temperature and O2 saturation on the production of recombinant proteins beta-galactosidase and human glucocerebrosidase by Spodoptera frugiperda cells (Sf9) infected with recombinant Autographa californica nuclear polyhedrosis virus was investigated.	Oxygen	30-32	galactosidase beta 1	Homo sapiens	86-104
31526567-8	2019	Mechanistically, PRDX1-regulated cerebral I-R injury was through the promotion of toll-like receptor-4 (TLR4), as proved by the evidence that TLR4 suppression abrogated the exacerbated effect of TLR4 on inflammatory response and apoptosis in oxygen and glucose deprivation (OGD)-treated primary microglial cells.	Oxygen	242-248	peroxiredoxin 1	Mus musculus	17-22
32039207-7	2019	In addition, TRADD was critical for the accumulation of reactive oxygen species (ROS), which contributed to RIPK1-independent necroptosis triggered by TNF.	Oxygen	65-71	TNFRSF1A-associated via death domain	Mus musculus	13-18
31848220-0	2020	Acute O2 sensing through HIF2alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.	Oxygen	6-8	endothelial PAS domain protein 1	Mus musculus	25-34
31638393-0	2019	Spectroscopic Characterization of mu-eta1:eta1-Peroxo Ligands Formed by Reaction of Dioxygen with Electron-Rich Iridium Clusters.	Oxygen	84-92	secreted phosphoprotein 1	Homo sapiens	37-41
8422960-3	1993	Geometry optimizations of the complex and the electrostatic potential of A both suggest that Mg2+ coordination preferably occurs in the region between the axial oxygen and the equatorial phosphoryl oxygen.	Oxygen	161-167	mucin 7, secreted	Homo sapiens	93-96
31638393-0	2019	Spectroscopic Characterization of mu-eta1:eta1-Peroxo Ligands Formed by Reaction of Dioxygen with Electron-Rich Iridium Clusters.	Oxygen	84-92	secreted phosphoprotein 1	Homo sapiens	42-46
31430465-8	2019	OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization.	Oxygen	154-160	myosin regulatory light chain interacting protein	Homo sapiens	69-72
31952197-3	2020	We found that ototoxicity in S1P2 knockout mice is dependent on reactive oxygen species (ROS) production and that S1P2 receptor activation with a specific agonist, CYM-5478, significantly attenuates cisplatin-induced defects, including hair cell degeneration in zebrafish and prolonged auditory brainstem response latency in rats.	Oxygen	73-79	chymosin	Mus musculus	164-167
8422960-3	1993	Geometry optimizations of the complex and the electrostatic potential of A both suggest that Mg2+ coordination preferably occurs in the region between the axial oxygen and the equatorial phosphoryl oxygen.	Oxygen	198-204	mucin 7, secreted	Homo sapiens	93-96
8422960-5	1993	Consequently, the Mg2+ ion at the active site of Tetrahymena-type ribozyme most likely lies in the regions between the axial and equatorial oxygens.	Oxygen	140-147	mucin 7, secreted	Homo sapiens	18-21
32170667-11	2020	In addition, the adhesion molecules are associated with the anthropometric parameters, oxygen saturation, and sleep architecture in the OSA-1 group.	Oxygen	87-93	AT-rich interaction domain 1A	Homo sapiens	136-141
8422960-6	1993	The axial-equatorial coordinations of Mg2+ ions conceivably increase the electronegativities of the axial oxygens and facilitate cleavage of the phosphodiester bond located at the junction of the intron and the exon.	Oxygen	106-113	mucin 7, secreted	Homo sapiens	38-41
31483333-4	2019	O2 homeostasis is critically intertwined with erythropoietic response in blood loss and anemia and the hormones that modulate iron mobilization and RBC production (e.g., erythropoietin, erythroferrone, and hepcidin) are intriguing markers for the monitoring of transfusion effectiveness in acute and chronic settings.	Oxygen	0-2	hepcidin antimicrobial peptide	Homo sapiens	206-214
1282302-8	1992	These data support the hypothesis that decreases in fetal oxygen availability may decrease fetal growth by decreasing IGF-I production and availability.	Oxygen	58-64	insulin-like growth factor I	Ovis aries	118-123
31616516-9	2019	In addition, STAT3 siRNA transfection and GYY4137 blocked HG-induced oxidative stress as evidenced by the decrease in reactive oxygen species generation, malondialdehyde content and NADPH oxidase 2 expression, and the increase in superoxide dismutase activity and glutathione level.	Oxygen	127-133	signal transducer and activator of transcription 3	Rattus norvegicus	13-18
31408201-0	2020	MiR-203a-3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen-induced retinopathy (OIR) rat model via targeting VEGFA and HIF-1alpha.	Oxygen	95-101	vascular endothelial growth factor A	Rattus norvegicus	152-157
31230964-4	2020	PARTICIPANTS: Cardiac surgery patients presenting oxygen saturation &lt;96% with Venturi mask 50%.	Oxygen	50-56	ankyrin repeat and KH domain containing 1	Homo sapiens	89-93
31918925-11	2020	In agreement with this role, the H6PD enzymatic response to both STZ-DM and MTF matched the activation of the NADPH-dependent antioxidant responses to the increased generation of reactive oxygen species caused by chronic hyperglycemia.	Oxygen	188-194	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	33-37
31529142-9	2019	A combination of both VAS1 variant alleles in a diploid yeast cell exhibited a more significant decrease in oxidative metabolism-dependent growth and in the oxygen consumption rate (reminiscent of the patient who carries two mutant VARS2 alleles).	Oxygen	157-163	valine--tRNA ligase	Saccharomyces cerevisiae S288C	22-26
1467445-2	1992	We have measured the enthalpy of binding oxygen and carbon monoxide to horse myoglobin, human hemoglobin A0 and sperm whale myoglobin in phosphate buffer at pH 7.6, with the enzyme reducing system of Hayashi.	Oxygen	41-47	myoglobin	Physeter catodon	124-133
31689783-7	2019	The expression of PLAC1 in trophoblasts was significantly decreased after treated with low oxygen concentration (P = .018).	Oxygen	91-97	placenta enriched 1	Homo sapiens	18-23
31570775-5	2020	Translating to humans, we find analogous dysfunctional interactions between hippocampus and prefrontal cortex in coupling of the fMRI blood oxygen level-dependent (BOLD) signal during working memory in healthy subjects carrying alleles associated with increased KCNH2-3.1 expression in brain.	Oxygen	140-146	potassium voltage-gated channel subfamily H member 2	Homo sapiens	262-267
1361511-7	1992	Both spectra were recorded at 77 K. Data presented in this work also provide the first spectral evidence indicating the low temperature (183 K) conversion of high-spin ferrous catalase into compound III (oxycatalase) in the presence of dioxygen.	Oxygen	236-244	catalase	Bos taurus	176-184
31799810-6	2020	Substructural damage and obvious mitochondria membrane potential depolarization are caused subsequently with the combined action of numerously reactive oxygen species production, ultimately initiating the apoptotic process through the translocation of cytochrome c to the cytoplasm and activating apoptotic markers including caspase-9 and -3.	Oxygen	152-158	caspase 9	Homo sapiens	325-341
31676791-4	2019	However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer).	Oxygen	188-194	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	63-87
31676791-4	2019	However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer).	Oxygen	188-194	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	89-92
33536736-6	2020	O2 uptake (Vo2 ) and CO2 output (Vco2 ) off-kinetics was examined using a mono-exponential model in which tau off (tauoff ) and mean response time (MRT) were determined.	Oxygen	0-2	microtubule associated protein tau	Homo sapiens	106-109
31683744-4	2019	In addition, we determined that native and recombinant PSG1, the most highly expressed member of the family, binds to  5 1 and induces the formation of focal adhesion structures resulting in adhesion of primary EVTs and EVT-like cell lines under 21% oxygen and 1% oxygen conditions.	Oxygen	250-256	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	55-59
1282726-8	1992	Moreover, an ET-3 concentration (500 pmol/l), which induced a dramatic fall in tubular sodium load, led to an increase of fractional sodium excretion and to a decrease of renal oxygen consumption.	Oxygen	177-183	endothelin 3	Rattus norvegicus	13-17
31683744-4	2019	In addition, we determined that native and recombinant PSG1, the most highly expressed member of the family, binds to  5 1 and induces the formation of focal adhesion structures resulting in adhesion of primary EVTs and EVT-like cell lines under 21% oxygen and 1% oxygen conditions.	Oxygen	264-270	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	55-59
1524435-1	1992	Ceruloplasmin catalyzed the incorporation of iron into apoferritin with a stoichiometry of 3.8 Fe(II)/O2.	Oxygen	102-104	ceruloplasmin	Rattus norvegicus	0-13
31717697-0	2019	Oxygen Tension Regulates Lysosomal Activation and Receptor Tyrosine Kinase Degradation.	Oxygen	0-6	ret proto-oncogene	Homo sapiens	50-74
31717697-6	2019	Our results link oxygen tension and lysosomal activity, provide a molecular explanation of the malignant phenotype associated with hypoxic tumors, and suggest activation of lysosomes may provide therapeutic benefit in RTK-targeted cancer therapy.	Oxygen	17-23	ret proto-oncogene	Homo sapiens	218-221
33227837-0	2020	Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning.	Oxygen	22-28	NLR family, pyrin domain containing 3	Mus musculus	32-37
33227837-3	2020	In this study we investigated the effects of hyperbaric oxygen (HBO2) on NLRP3 inflammasome activation after ACOP.	Oxygen	56-62	NLR family, pyrin domain containing 3	Mus musculus	73-78
1490257-2	1992	Ascorbic acid is a strong antioxidant agent, whereas myoglobin is known to act as an oxygen reservoir.	Oxygen	85-91	myoglobin	Rattus norvegicus	53-62
31843010-9	2019	Notably, increased glycolysis in POLG1Q811R MDNS was suggested by the increase in PFKM and LDHA levels and confirmed using functional analysis of glycolytic rate and oxygen consumption levels.	Oxygen	166-172	DNA polymerase gamma, catalytic subunit	Homo sapiens	33-43
31781156-13	2019	Yet, sdha-2 and nduf2-2 expression is increased in the early embryo and in dauer larvae, stages where there is low oxygen tension.	Oxygen	115-121	Complex I-49kD	Caenorhabditis elegans	16-23
1526970-3	1992	In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine.	Oxygen	39-45	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	97-101
31627452-6	2019	The results showed that the limiting oxygen index (LOI) values increased from 19.7% for the waterborne epoxy resin to 28.7% for the EP1 with 20 wt% KC-IFR.	Oxygen	37-43	prostaglandin E receptor 1	Homo sapiens	132-135
31921851-6	2019	In contrast, oxygen-glucose deprivation (OGD)-induced downregulation of NFAT5 expression was reversed by treating with hypertonic saline, which ameliorated aberrant NKCC1 expression.	Oxygen	13-27	solute carrier family 12 member 2	Homo sapiens	165-170
31911897-9	2019	Also, we emphasize recent results that link TERT to mitochondria and protection to reactive oxygen species suggesting a protective role of TERT in neurons.	Oxygen	92-98	telomerase reverse transcriptase	Mus musculus	139-143
1499105-2	1992	To test the hypothesis that 5"-nucleotidase activity during ischemia is attenuated by oxygen-derived free radicals, we measured ischemia-induced reactive hyperemic flow, adenosine release, and 5"-nucleotidase activity in dogs (n = 62).	Oxygen	86-92	5'-nucleotidase ecto	Canis lupus familiaris	28-43
31615975-3	2019	Thioredoxin-interacting protein (TXNIP) promotes cellular oxidative stress by inhibiting thioredoxin reducing capacity and is in turn inversely regulated by reactive oxygen species levels; however, its role in oxidative stress-induced RPE cell dysfunction and the mechanistic link between TXNIP and autophagy are largely unknown.	Oxygen	166-172	thioredoxin	Homo sapiens	89-100
31611596-11	2019	Together, luseogliflozin inhibits hypoxia-induced HIF-1alpha accumulation by suppressing mitochondrial oxygen consumption.	Oxygen	103-109	hypoxia inducible factor 1, alpha subunit	Mus musculus	50-60
31687088-7	2019	Lycorine attenuated oxidized transient receptor potential cation channel, mucolipin subfamily (TRPML1) by reducing mitochondrial reactive oxygen species (mROS) and decreased transcription factor EB (TFEB) nuclear translocation.	Oxygen	138-144	mucolipin 1	Mus musculus	95-101
20301301-1	1993	More than 75% of full-term neonates with PCD have "neonatal respiratory distress" requiring supplemental oxygen for days to weeks.	Oxygen	105-111	dynein axonemal heavy chain 5	Homo sapiens	41-44
31805953-14	2019	Mechanistically, microglia with elevated G6PD activity/expression produced excessive NADPH and provided abundant substrate to over-activated NADPH oxidase (NOX2) leading to production of excessive reactive oxygen species (ROS).	Oxygen	206-212	glucose-6-phosphate dehydrogenase 2	Mus musculus	41-45
1410589-2	1992	Mouse P50 (partial pressure of oxygen at half saturation) was estimated using an ABL blood gas analyzer; radiation response determined from tumour regrowth and local tumour control assays; and tumour blood perfusion measured with a 86RbCl extraction procedure.	Oxygen	31-37	dynactin 2	Mus musculus	6-9
31454332-7	2019	In a mouse model of oxygen-induced retinopathy (OIR), resembling retinopathy of prematurity (ROP), loss of Casp-8 in ECs was beneficial, as pathological neovascularization was reduced in Casp-8ECko pups.	Oxygen	20-26	caspase 8	Mus musculus	107-113
31454332-7	2019	In a mouse model of oxygen-induced retinopathy (OIR), resembling retinopathy of prematurity (ROP), loss of Casp-8 in ECs was beneficial, as pathological neovascularization was reduced in Casp-8ECko pups.	Oxygen	20-26	caspase 8	Mus musculus	187-193
31591388-5	2019	Conversely, ectopic expression of mutant IDH1 or treatment of cells with cell-permeable D-2-HG promotes the accumulation of lipid reactive oxygen species (ROS) and subsequently ferroptosis.	Oxygen	139-145	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	41-45
1357020-1	1992	Tyrosine hydroxylase (TH) protein was measured in the carotid body and adrenal gland of rats exposed to normobaric hypoxia (10% O2 in nitrogen) for 3, 7, 14 or 22 days.	Oxygen	128-130	tyrosine hydroxylase	Rattus norvegicus	0-20
31135464-10	2019	Hyperbaric oxygen reduced the inflammatory reaction and glial scar formation by inhibiting inflammation-related factors iNOS and COX-2 and glial scar-related components GFAP and NG2.	Oxygen	11-17	chondroitin sulfate proteoglycan 4	Rattus norvegicus	178-181
31593641-2	2019	ASK1 is activated in response to a diverse array of stresses such as endoplasmic reticulum stress, lipopolysaccharides, tumor necrosis factor alpha, and reactive oxygen species.	Oxygen	162-168	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-4
31677073-7	2019	Mechanistically, synergistic induction of mitochondrial reactive oxygen species (mtROS) is a crucial event in the enhancement effect of CBZ on ATP- or nigericin-induced NLRP3 inflammasome activation.	Oxygen	65-71	NLR family, pyrin domain containing 3	Mus musculus	169-174
31365782-6	2019	In primary astrocyte cultures, the microRNA miR-424 was found to target nuclear factor IA (NFIA); miR-424 agomir increased DNMT1 and H3K27me3 levels in U87 cells subjected to oxygen and glucose deprivation and induced cell cycle arrest in primary astrocytes while suppressing reactive astrocytosis, thereby preserving the structure of neurons and their axons in MCAO mice.	Oxygen	175-181	nuclear factor I/A	Mus musculus	72-89
31365782-6	2019	In primary astrocyte cultures, the microRNA miR-424 was found to target nuclear factor IA (NFIA); miR-424 agomir increased DNMT1 and H3K27me3 levels in U87 cells subjected to oxygen and glucose deprivation and induced cell cycle arrest in primary astrocytes while suppressing reactive astrocytosis, thereby preserving the structure of neurons and their axons in MCAO mice.	Oxygen	175-181	nuclear factor I/A	Mus musculus	91-95
1357020-1	1992	Tyrosine hydroxylase (TH) protein was measured in the carotid body and adrenal gland of rats exposed to normobaric hypoxia (10% O2 in nitrogen) for 3, 7, 14 or 22 days.	Oxygen	128-130	tyrosine hydroxylase	Rattus norvegicus	22-24
1433311-10	1992	This should however not detract from the utility of the model in elucidating myoglobin function under oxygen limiting conditions.	Oxygen	102-108	myoglobin	Rattus norvegicus	77-86
31279089-6	2019	adTrx1 and adTrxR1 significantly reduced the increases in O2 - level in H2O2-treated HPASM cells at 24 h. Furthermore, HPASM cells transfected with Trx1 or TrxR1 siRNA showed increases in ROS levels with or without H2O2 at 5 min.	Oxygen	58-62	thioredoxin	Homo sapiens	2-6
31436417-6	2019	We show here that polysulfides bind to inactive ferric IDO1 and reduce it to the oxygen-binding ferrous state, thus activating IDO1 to maximal turnover even at low, physiologically significant concentrations.	Oxygen	81-87	indoleamine 2,3-dioxygenase 1	Homo sapiens	127-131
1321609-3	1992	The effect of GTP gamma S is modified by Mg2+: the cations enhance the O2- generation at low concentrations of GTP gamma S, whereas they attenuate the activity at higher concentrations of GTP gamma S. In presence of 10 microM GTP gamma S, the maximal activity is observed at 0.1 microM Mg2+, which is several-fold higher than that at 1 mM Mg2+.	Oxygen	71-73	mucin 7, secreted	Homo sapiens	41-44
31553952-4	2019	In addition, knock-down of LncRNA-XIST also promoted reactive oxygen species (ROS) production and NLRP3 inflammasome activation.	Oxygen	62-68	X inactive specific transcript	Homo sapiens	34-38
31619944-5	2019	Increased reactive oxygen species (ROS) resulting from inefficiencies in the electron transport chain also contribute to the formation of alpha-synuclein aggregates and neuronal loss.	Oxygen	19-25	synuclein alpha	Homo sapiens	138-153
31665600-5	2019	The present investigation offers a comprehensive computational approach for the determination of binding modes and characteristic binding times of small molecules inside proteins, which is then used to reveal several O2 binding sites near the flavin adenine dinucleotide cofactor of the ETF enzyme.	Oxygen	217-219	TEA domain transcription factor 2	Homo sapiens	287-290
1617671-6	1992	The inhibitors of ADP-ribose transferase benzamide and 3-amino-benzamide suppressed the elongation of the c-fos message and the de novo synthesis of nuclear factors, among them c-Fos and c-Jun, which bind to the fos-AP-1 motif in vitro only following stimulation with active oxygen.	Oxygen	275-281	jun proto-oncogene	Mus musculus	187-192
31568785-10	2019	Furthermore, anta-miR-324-5p noticeably increased the cellular oxygen consumption in primary BAT and iWAT cells.	Oxygen	63-69	microRNA 324	Mus musculus	18-25
31493760-2	2019	In this study, molybdenum (Mo) and sulphur (S) were simultaneously introduced onto the surface of oxygen-doped graphitic carbon nitride (OCN) for the enhancement of Cd2+ adsorption.	Oxygen	98-104	CD2 molecule	Homo sapiens	165-168
31233984-0	2019	Z-scheme I-BiOCl/CdS with abundant oxygen vacancies as highly effective cathodic material for photocathodic immunoassay.	Oxygen	35-41	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
1629229-0	1992	A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate.	Oxygen	65-67	myoglobin	Physeter catodon	32-41
31422074-7	2019	The loss of BVRA resulted in the reduction of mitochondria number, decreased expression of markers of mitochondrial biogenesis, uncoupling, oxidation, and fusion, which paralleled reduced mitochondrial oxygen consumption.	Oxygen	202-208	biliverdin reductase A	Mus musculus	12-16
31441297-1	2019	The end-on oxygen-bound sulfur monoxide (SO) complex of titanium oxyfluoride [OTiF2(eta1-OS)] was prepared via the isomerization of a bidentate sulfur dioxide complex of titanium difluoride [TiF2(O2S)] under UV-vis irradiation in cryogenic matrixes.	Oxygen	11-17	secreted phosphoprotein 1	Homo sapiens	84-88
31441297-1	2019	The end-on oxygen-bound sulfur monoxide (SO) complex of titanium oxyfluoride [OTiF2(eta1-OS)] was prepared via the isomerization of a bidentate sulfur dioxide complex of titanium difluoride [TiF2(O2S)] under UV-vis irradiation in cryogenic matrixes.	Oxygen	196-199	secreted phosphoprotein 1	Homo sapiens	84-88
31441297-3	2019	According to the experimental and theoretical results, the OTiF2(eta1-OS) complex was characterized to possess a triplet ground state, with the oxygen-bound SO ligand being similar in character to the neutral diatomic SO molecule.	Oxygen	144-150	secreted phosphoprotein 1	Homo sapiens	65-69
31441297-5	2019	The formation of OTiF2(eta1-OS) involves cleavage of the S-O bond of TiF2(O2S) with an energy barrier of 25.6 kcal/mol.	Oxygen	74-77	secreted phosphoprotein 1	Homo sapiens	23-27
30879700-2	2019	The purpose of this study is to describe the use of end tidal oxygen (eto2) during rapid sequence intubation in the emergency department.	Oxygen	62-68	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	70-74
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	151-157	endothelial PAS domain protein 1	Homo sapiens	19-50
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	151-157	endothelial PAS domain protein 1	Homo sapiens	52-61
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	266-272	endothelial PAS domain protein 1	Homo sapiens	19-50
31798631-3	2019	We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis.	Oxygen	266-272	endothelial PAS domain protein 1	Homo sapiens	52-61
31703091-9	2019	Furthermore, silencing of Atg5 was associated with inflammation of IECs, activation of the mitogen-activated protein kinase (MAPK) signaling pathway by the intracellular reactive oxygen species accumulation, and NF-kappaB p65 phosphorylation.	Oxygen	179-185	autophagy related 5	Rattus norvegicus	26-30
31660566-2	2019	We search for the equilibrium structures of phosphorene oxides, POx with various oxygen concentrations x (0 &lt;= x &lt;= 1).	Oxygen	81-87	proline dehydrogenase 1	Homo sapiens	64-67
1629229-13	1992	The distance between the nearest side chain atom of residue 29 and the second atom of the bound oxygen molecule is 3.2 A in the Phe29 protein and 4.9 A in native myoglobin.	Oxygen	96-102	myoglobin	Physeter catodon	162-171
31697676-4	2019	First, we sequenced the exomes of 100 mice sampled from different elevations and discovered that several SNPs in the gene Epas1, which encodes the oxygen sensitive subunit of HIF-2alpha, exhibited extreme allele frequency differences between highland and lowland populations.	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	122-127
31697676-4	2019	First, we sequenced the exomes of 100 mice sampled from different elevations and discovered that several SNPs in the gene Epas1, which encodes the oxygen sensitive subunit of HIF-2alpha, exhibited extreme allele frequency differences between highland and lowland populations.	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	175-185
31162977-5	2019	Kcne2 deletion reduced blood O2, increased CO2, increased pulmonary apoptosis, and increased inflammatory mediators TNF-alpha, IL-6, and leukocytes in bronchoalveolar lavage (BAL) fluids.	Oxygen	29-31	potassium voltage-gated channel, Isk-related subfamily, gene 2	Mus musculus	0-5
1629229-14	1992	The equilibrium constants for O2 binding to Ala29, Val29, and Leu29 (native) myoglobin are the same, approximately 1.0 x 10(6) M-1 at 20 degrees C, whereas that for the Phe29 protein is markedly greater, 15 x 10(6) M-1.	Oxygen	30-32	myoglobin	Physeter catodon	77-86
1451028-3	1992	Endothelin-1 has been proposed by us as a local mediator for oxygen after demonstrating that it is formed within the ductus and is a potent ductus constrictor.	Oxygen	61-67	EDN1	Ovis aries	0-12
31294895-8	2019	Similar results were obtained when Atf7-/- and WT mouse embryonic fibroblasts (MEFs) were cultured under 20% oxygen conditions, which induces cellular senescence via oxidative stress.	Oxygen	109-115	activating transcription factor 7	Mus musculus	35-39
31596281-2	2019	As substantiated by NMR spectroscopy and single-crystal X-ray diffraction, the phosphine-borane ligand iPr2P-(o-C6H4)-BFxyl2 1 [Fxyl = 3,5-(F3C)2C6H3] engages in tight eta3-BCC or eta1-B coordination, depending on the metal environment.	Oxygen	107-124	secreted phosphoprotein 1	Homo sapiens	180-184
31603662-3	2019	Benefiting from the highly porous nanostructure and conductive carbon skeleton, H-CoP@NC is capable of working as highly active and durable bifunctional electrocatalyst for both hydrogen and oxygen evolution reaction.	Oxygen	191-197	caspase recruitment domain family member 16	Homo sapiens	82-85
31430465-0	2019	The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.	Oxygen	49-55	myosin regulatory light chain interacting protein	Homo sapiens	103-106
31428866-5	2019	Antagonism of central TRPV4 caused an increase in body temperature in rats exposed to 28  C, but not in those exposed to 21  C. The body temperature increase at 28  C was accompanied by an increase in oxygen consumption and an earlier reduction of the heat loss index.	Oxygen	201-207	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	22-27
1451028-6	1992	We report that release of endothelin-1 from the ductus tends to increase with the oxygen concentration up to a value mimicking the neonatal condition.	Oxygen	82-88	EDN1	Ovis aries	26-38
1451028-8	1992	These results implicate endothelin-1 as the effector agent for oxygen in the ductus and, by extension, assign to this peptide a critical role in the closure of the vessel at birth.	Oxygen	63-69	EDN1	Ovis aries	24-36
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	39-41	surfactant protein A1	Homo sapiens	341-371
31234015-2	2019	Here, we established that the mitochondrial flavoprotein long-chain acyl-CoA dehydrogenase (LCAD), which catalyzes a key step in mitochondrial FAO, directly produces H2O2in vitro by leaking electrons to oxygen.	Oxygen	203-209	acyl-CoA dehydrogenase long chain	Homo sapiens	57-90
31234015-2	2019	Here, we established that the mitochondrial flavoprotein long-chain acyl-CoA dehydrogenase (LCAD), which catalyzes a key step in mitochondrial FAO, directly produces H2O2in vitro by leaking electrons to oxygen.	Oxygen	203-209	acyl-CoA dehydrogenase long chain	Homo sapiens	92-96
31516349-11	2019	For a lower ambient oxygen concentration, expression of TRPV4 channel is higher, suggesting that TRPV4 channel may be one important mechanism involved in calcium overload in acute hypoxic exercise.	Oxygen	20-26	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	56-61
31516349-11	2019	For a lower ambient oxygen concentration, expression of TRPV4 channel is higher, suggesting that TRPV4 channel may be one important mechanism involved in calcium overload in acute hypoxic exercise.	Oxygen	20-26	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	97-102
31513960-4	2019	For the ECL analysis, s-PdNFs could effectively quench the ECL intensity of peroxydisulfate/oxygen (S2O82-/O2) system via ECL resonance energy transfer (ECL-RET).	Oxygen	92-98	ret proto-oncogene	Homo sapiens	157-160
31513960-4	2019	For the ECL analysis, s-PdNFs could effectively quench the ECL intensity of peroxydisulfate/oxygen (S2O82-/O2) system via ECL resonance energy transfer (ECL-RET).	Oxygen	107-109	ret proto-oncogene	Homo sapiens	157-160
31736881-7	2019	The nocturnal total metanephrine concentration was positively and significantly associatedwith the percentage of sleeping time spent with oxygen saturation &lt;90%(CT90).	Oxygen	138-144	kinesin family member 20B	Homo sapiens	164-168
31444514-0	2019	Anti-angiogenic and anti-inflammatory effects of CD200-CD200R1 axis in oxygen-induced retinopathy mice model.	Oxygen	71-77	CD200 antigen	Mus musculus	49-54
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	surfactant protein A1	Homo sapiens	341-371
31444514-1	2019	OBJECTIVE: In this study, the expression changes and the potential effects of CD200 and its receptors during the process of retinal neovascularization (RNV) development had been detected, using a classic oxygen-induced retinopathy (OIR) mice model and CD200Fc (a CD200R1 agonist) intravitreal injection.	Oxygen	204-210	CD200 antigen	Mus musculus	78-83
31444350-3	2019	The Pt atom in the ensemble is 100-1000 times more active than their single-atom Pt1/CeO2 parent in catalyzing the low-temperature CO oxidation under oxygen-rich conditions.	Oxygen	150-156	zinc finger protein 77	Homo sapiens	81-84
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	surfactant protein A1	Homo sapiens	341-371
1316735-6	1992	The lack of phosphorylation of 9-(5,5-difluoro-5-phosphonopentyl)guanine by guanylate kinase is explained by the decreased nucleophilic character of the oxygen atoms of the phosphonate group rather than by inadequate binding to the GMP-binding site.	Oxygen	153-159	guanylate kinase 1	Homo sapiens	76-92
31692484-0	2019	Thymosin beta4 prevents oxygen-glucose deprivation/reperfusion-induced injury in rat cortical neurons.	Oxygen	24-30	thymosin beta 4, X-linked	Rattus norvegicus	0-14
31032948-6	2019	Therefore, hypoxic MLO-Y4 cells simulated by 100 mumol/L CoCl2 or 2% O2 stably expressed HIF-1alpha proteins and upregulated the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) at both the messenger RNA (mRNA) and protein level.	Oxygen	69-71	hypoxia inducible factor 1, alpha subunit	Mus musculus	89-99
31032948-6	2019	Therefore, hypoxic MLO-Y4 cells simulated by 100 mumol/L CoCl2 or 2% O2 stably expressed HIF-1alpha proteins and upregulated the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) at both the messenger RNA (mRNA) and protein level.	Oxygen	69-71	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	143-193
1324116-2	1992	Factors contributing to the fat loss include an exercise-induced hypertrophy of lean tissue, a loss of energy through a cold-induced ketonuria, a stimulation of resting metabolism, increases in the energy cost of movement, and a lower yield of energy per litre of oxygen consumed.	Oxygen	264-270	FAT atypical cadherin 1	Homo sapiens	28-31
31032948-6	2019	Therefore, hypoxic MLO-Y4 cells simulated by 100 mumol/L CoCl2 or 2% O2 stably expressed HIF-1alpha proteins and upregulated the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) at both the messenger RNA (mRNA) and protein level.	Oxygen	69-71	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	195-200
31596196-2	2019	Here, we found that HBV X protein (HBx) natural variants containing Ser-101 instead of Pro-101 increase reactive oxygen species levels in the mitochondria and activate the ataxia telangiectasia mutated/checkpoint kinase 2 pathway in the nucleus, resulting in the phosphorylation of p53 at Ser-15 and Ser-20 and the subsequent upregulation of its protein levels.	Oxygen	113-119	X protein	Hepatitis B virus	20-33
31596196-2	2019	Here, we found that HBV X protein (HBx) natural variants containing Ser-101 instead of Pro-101 increase reactive oxygen species levels in the mitochondria and activate the ataxia telangiectasia mutated/checkpoint kinase 2 pathway in the nucleus, resulting in the phosphorylation of p53 at Ser-15 and Ser-20 and the subsequent upregulation of its protein levels.	Oxygen	113-119	X protein	Hepatitis B virus	35-38
31209961-0	2019	Utilizing the Space-Charge Region of the FeNi-LDH/CoP p-n Junction to Promote Performance in Oxygen Evolution Electrocatalysis.	Oxygen	93-99	caspase recruitment domain family member 16	Homo sapiens	50-53
31255729-4	2019	High-fat diet (HFD)-fed NPR-C- mice exhibited obesity resistance and higher oxygen consumption.	Oxygen	76-82	natriuretic peptide receptor 3	Mus musculus	24-29
1470566-2	1992	The purpose of this study was to evaluate the effects of exogenous PYY on pancreatic blood flow and oxygen consumption.	Oxygen	100-106	peptide YY	Canis lupus familiaris	67-70
31235261-6	2019	The crystal structure of the Mcl-1 bound ligand represents a unique binding mode to the BH3 binding pocket where binding affinity is achieved, in part, through a sulfonamide oxygen/Arg263 interaction.	Oxygen	174-180	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	29-34
31460739-0	2019	Dendrite-Free Fluorinated Graphene/Lithium Anode Enabling In-Situ LiF Formation for High-Performance Lithium-Oxygen Cells.	Oxygen	109-115	LIF interleukin 6 family cytokine	Homo sapiens	66-69
1592734-5	1992	In lungs ventilated with 3% oxygen, 10 nM ET-3 completely reversed the resultant hypoxic vasoconstriction (HPV) by 100 +/- 8%, an effect unchanged by either indomethacin (1 microM) or glibenclamide (10 microM).	Oxygen	28-34	endothelin 3	Rattus norvegicus	42-46
31493869-4	2019	By investigating an in vitro model, we reveal that REDD1 is induced by HIF-1alpha in H9c2 cells subjected to oxygen/glucose deprivation followed by reperfusion (OGD/R).	Oxygen	109-115	DNA-damage-inducible transcript 4	Rattus norvegicus	51-56
30959013-6	2019	In addition, inverse correlations also existed in the reconstructed group between distensibility of the DAo and the exercise variables such as peak oxygen pulse (R = 0.56, p = 0.02), peak oxygen consumption (R = 0.63, p = 0.008), oxygen consumption at ventilatory anaerobic threshold (R = 0.48, p = 0.04), and peak work (R = 0.54, p = 0.02).	Oxygen	148-154	D-amino acid oxidase	Homo sapiens	104-107
30959013-6	2019	In addition, inverse correlations also existed in the reconstructed group between distensibility of the DAo and the exercise variables such as peak oxygen pulse (R = 0.56, p = 0.02), peak oxygen consumption (R = 0.63, p = 0.008), oxygen consumption at ventilatory anaerobic threshold (R = 0.48, p = 0.04), and peak work (R = 0.54, p = 0.02).	Oxygen	188-194	D-amino acid oxidase	Homo sapiens	104-107
30959013-6	2019	In addition, inverse correlations also existed in the reconstructed group between distensibility of the DAo and the exercise variables such as peak oxygen pulse (R = 0.56, p = 0.02), peak oxygen consumption (R = 0.63, p = 0.008), oxygen consumption at ventilatory anaerobic threshold (R = 0.48, p = 0.04), and peak work (R = 0.54, p = 0.02).	Oxygen	188-194	D-amino acid oxidase	Homo sapiens	104-107
31075501-4	2019	Acute, short-term hypoxia caused an increase in hemoglobin (Hb) O2 affinity (decrease in P50), due to a decrease in erythrocyte ATP after erythrocyte swelling.	Oxygen	64-66	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Danio rerio	89-92
31132167-5	2019	Three patients (two of whom were brothers) had HBB mutations associated with increased oxygen-affinity hemoglobin-one had a heterozygous Hb McKees Rocks HBB:c.438T > A (p.Tyr146*), and two brothers showed heterozygous Hb Rainier HBB:c.437A > G (p.Tyr146Cys).	Oxygen	87-93	hemoglobin subunit beta	Homo sapiens	47-50
31649237-5	2019	Operando synchrotron radiation X-ray absorption spectroscopy and infrared spectroscopy identify the dynamic adsorption of single oxygen atom on Ru site under working potentials, and theoretical calculations demonstrate that the O-Ru1-N4 site is responsible for the high OER activity and stability.	Oxygen	129-135	Scm like with four mbt domains 1	Homo sapiens	230-233
31614723-4	2019	Pin1 silencing caused increased levels of reactive oxygen species, upregulated energy metabolism as suggested by raised levels of total ATP content and mRNA of SIRT1, PGC1alpha, NRF1; enhanced mitochondrial fission events as supported by raised protein expression of FIS1 and DRP1.	Oxygen	51-57	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
1579104-12	1992	One of these, PET494, is itself translationally regulated by oxygen in a heme-independent fashion.	Oxygen	61-67	Pet494p	Saccharomyces cerevisiae S288C	14-20
1579067-7	1992	The involvement of these active oxygen species in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, catalase, iodide, mannitol, formate and sodium azide.	Oxygen	32-38	catalase	Bos taurus	138-146
1740136-7	1992	This redox process is also important in the in vitro enzyme assay, where ATP-citrate lyase is in redox equilibrium with oxygen and either dithiothreitol or 2-mercaptoethanol.	Oxygen	120-126	ATP citrate lyase	Rattus norvegicus	73-90
1425653-1	1992	The effects of two levels of caffeine ingestion (5 mg.kg-1, CAF1, and 10 mg.kg-1, CAF2) on postexercise oxygen consumption was investigated in six untrained women aged 20.5 (SEM 0.5) years.	Oxygen	104-110	CCR4-NOT transcription complex subunit 8	Homo sapiens	82-86
1425653-3	1992	During exercise, oxygen consumption was found to be significantly higher in the CAF1 and CAF2 trials, compared to CON (P &lt; 0.05).	Oxygen	17-23	chromatin assembly factor 1 subunit A	Homo sapiens	80-84
1425653-3	1992	During exercise, oxygen consumption was found to be significantly higher in the CAF1 and CAF2 trials, compared to CON (P &lt; 0.05).	Oxygen	17-23	CCR4-NOT transcription complex subunit 8	Homo sapiens	89-93
1425653-4	1992	During the hour postexercise, oxygen consumption in CAF1 and CAF2 remained significantly higher than in CON (P &lt; 0.05).	Oxygen	30-36	chromatin assembly factor 1 subunit A	Homo sapiens	52-56
1425653-4	1992	During the hour postexercise, oxygen consumption in CAF1 and CAF2 remained significantly higher than in CON (P &lt; 0.05).	Oxygen	30-36	CCR4-NOT transcription complex subunit 8	Homo sapiens	61-65
1355574-0	1992	Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: role of leukocytes revised.	Oxygen	59-65	intercellular adhesion molecule 1	Mus musculus	0-33
1355574-3	1992	In addition to regulating neutrophil diapedesis, intercellular adhesion molecule-1 (ICAM-1) expression is marked on inflamed alveolar epithelium, suggesting a role for ICAM-1 in oxygen-induced, neutrophil-mediated parenchymal damage.	Oxygen	178-184	intercellular adhesion molecule 1	Mus musculus	49-82
1355574-3	1992	In addition to regulating neutrophil diapedesis, intercellular adhesion molecule-1 (ICAM-1) expression is marked on inflamed alveolar epithelium, suggesting a role for ICAM-1 in oxygen-induced, neutrophil-mediated parenchymal damage.	Oxygen	178-184	intercellular adhesion molecule 1	Mus musculus	84-90
1355574-3	1992	In addition to regulating neutrophil diapedesis, intercellular adhesion molecule-1 (ICAM-1) expression is marked on inflamed alveolar epithelium, suggesting a role for ICAM-1 in oxygen-induced, neutrophil-mediated parenchymal damage.	Oxygen	178-184	intercellular adhesion molecule 1	Mus musculus	168-174
1355574-7	1992	These results confirm the contribution of leukocytes in the pathogenesis of pulmonary oxygen toxicity and indicate that antagonism of ICAM-1 may provide a therapeutic approach to reducing hyperoxic lung injury and dysfunction.	Oxygen	86-92	intercellular adhesion molecule 1	Mus musculus	134-140
1757301-0	1991	Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity.	Oxygen	16-18	monoamine oxidase A	Rattus norvegicus	33-50
1757301-3	1991	We investigated the relationship between regional generation of hydrogen peroxide (H2O2) in the brain in the presence of an irreversible inhibitor of catalase, aminotriazole (ATZ), and protection from CNS O2 toxicity by a monoamine oxidase (MAO) inhibitor, pargyline.	Oxygen	85-87	monoamine oxidase A	Rattus norvegicus	222-239
1757301-8	1991	These findings indicate that H2O2 generated by MAO during hyperoxia is important to the pathogenesis of CNS O2 toxicity in rats.	Oxygen	31-33	monoamine oxidase A	Rattus norvegicus	47-50
1877661-6	1991	Vasodilation to all activated oxygen species was largely reversible with only the hydroxyl radical encouraging combination of xanthine oxidase, hypoxanthine, H2O2, and FeCl3, causing significant dilation 20 min after removal of treatment.	Oxygen	30-36	xanthine dehydrogenase	Sus scrofa	126-142
2046677-3	1991	Furthermore, we have shown that the CYB2 promoter contains one cis negative regulatory region and two heme-dependent positive regions, one of which is controlled by the transcriptional regulator CYP1 (HAP1) which is involved in the modulation of the expression of several oxygen-regulated genes.	Oxygen	272-278	L-lactate dehydrogenase (cytochrome)	Saccharomyces cerevisiae S288C	36-40
1947368-6	1991	The alveolar-arterial oxygen difference (A-aPO2) was significantly higher in the obese patients.	Oxygen	22-28	TNF receptor superfamily member 10a	Homo sapiens	43-47
31658614-7	2019	Sixteen weeks after Sirt1 deletion an increase in mitochondrial reactive oxygen species (ROS) production and a higher rate of oxidative damage were observed, suggesting disruption of the ROS production/detoxification balance.	Oxygen	73-79	sirtuin 1	Mus musculus	20-25
31434494-5	2019	In murine models of pathological ocular neovascularization, such as oxygen-induced retinopathy and laser-induced choroidal neovascularization models, cKIT and SCF expression was significantly increased in ocular tissues, and blockade of cKIT and SCF using cKit mutant mice and anti-SCF neutralizing IgG substantially suppressed pathological ocular neovascularization.	Oxygen	68-74	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	150-154
31434494-5	2019	In murine models of pathological ocular neovascularization, such as oxygen-induced retinopathy and laser-induced choroidal neovascularization models, cKIT and SCF expression was significantly increased in ocular tissues, and blockade of cKIT and SCF using cKit mutant mice and anti-SCF neutralizing IgG substantially suppressed pathological ocular neovascularization.	Oxygen	68-74	kit ligand	Mus musculus	159-162
31434494-7	2019	Inhibition of beta-catenin-mediated transcription using chemical inhibitors blocked SCF-induced in vitro angiogenesis in hypoxia, and injection of a beta-catenin agonist into cKit mutant mice with oxygen-induced retinopathy significantly enhanced pathological neovascularization in the retina.	Oxygen	197-203	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	175-179
31448908-3	2019	The furnace with the existing low-NOx combustion art showed NOx emissions of about 900 mg/m3 at 6% O2 and carbon in fly ash of about 5%.	Oxygen	99-101	NADPH oxidase	Drosophila melanogaster	34-37
31229884-11	2019	IC50hCOX-1 value of 11 determined by measuring the O2 consumption during the bis-oxygenation of the arachidonic acid catalysed by COX-1 was found to be equal to 1.8 nM.	Oxygen	51-53	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	4-10
31229884-11	2019	IC50hCOX-1 value of 11 determined by measuring the O2 consumption during the bis-oxygenation of the arachidonic acid catalysed by COX-1 was found to be equal to 1.8 nM.	Oxygen	51-53	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	5-10
31617496-6	2019	Of anti-MDA5 antibody-positive dermatomyositis patients, 57.1% developed RP-ILD, and in those with RP-ILD, serum ferritin level was markedly high and partial pressure of arterial oxygen (PaO2) was significantly low at first visit.	Oxygen	179-185	interferon induced with helicase C domain 1	Homo sapiens	8-12
31476902-8	2019	At day 10, cardiac TLR4, Il (interleukin) 18, and Il1beta expression were increased in oxygen-exposed compared with room air controls.	Oxygen	87-93	interleukin 18	Rattus norvegicus	25-44
29862863-3	2019	In KIR6.1 deficient mice resting cerebral blood flow and brain parenchymal partial pressure of oxygen (PO2) were found to be markedly lower compared to that in their wildtype littermates.	Oxygen	95-101	potassium inwardly-rectifying channel, subfamily J, member 8	Mus musculus	3-9
31554796-6	2019	Furthermore, reactive oxygen species (ROS) produced by the NADPH oxidase Nox in enterocytes, are required for p38 activation in enterocytes following infection or wounding, and for ISC activation upon infection or detergent exposure.	Oxygen	22-28	NADPH oxidase	Drosophila melanogaster	73-76
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	toll like receptor 4	Homo sapiens	87-91
31620128-4	2019	CRBN interrupted the association of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)-TNF-receptor associated factor 6 (TRAF6) complex, thereby inhibiting the ubiquitination of ECSIT, which plays a pivotal role for the production of mitochondrial reactive oxygen species (mROS).	Oxygen	279-285	TNF receptor associated factor 6	Homo sapiens	143-148
31511042-10	2019	We found an association between microcirculatory oxygen saturation and PAI-1 levels (rho = - 0.3; p = 0.007).	Oxygen	49-55	serpin family E member 1	Homo sapiens	71-76
31645842-4	2019	It has been reported that decreased levels of the mitochondrial inner membrane proteins TIMM23 and NDUFS3 are associated with the increased generation of reactive oxygen species and mitochondrial depolarization.	Oxygen	163-169	NADH:ubiquinone oxidoreductase core subunit S3	Homo sapiens	99-105
31565149-0	2019	Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis.	Oxygen	171-177	NADPH oxidase 5	Homo sapiens	69-84
31202172-3	2019	2% O2 and 48 h were screened as optimal oxygen concentration and effect time, respectively, by determining cell apoptosis and mRNA expression of ASIC3, hypoxia inducible factor-1alpha (HIF-1alpha) and aquaporin 3.	Oxygen	40-46	acid sensing ion channel subunit 3	Homo sapiens	145-150
31071449-2	2019	Herein, we design a traceable nanoplatform (DOX/Met/BSA-HA-CDs) by reducing oxygen (O2) consumption to overcome the hypoxia-caused cancer therapy.	Oxygen	76-82	SAFB like transcription modulator	Homo sapiens	48-51
31071449-2	2019	Herein, we design a traceable nanoplatform (DOX/Met/BSA-HA-CDs) by reducing oxygen (O2) consumption to overcome the hypoxia-caused cancer therapy.	Oxygen	84-86	SAFB like transcription modulator	Homo sapiens	48-51
31071449-6	2019	Ex vivo immunofluorescence staining revealed that the DOX/Met/BSA-HA-CDs nanoparticles greatly reduce O2 consumption in tumor site.	Oxygen	102-104	SAFB like transcription modulator	Homo sapiens	58-61
31267164-2	2019	In Hb M iron is present in the oxidized ferric state (Fe3+) not in the reduced ferrous form (Fe2+) and this reduces the ability of hemoglobin to bind oxygen.	Oxygen	150-156	hemoglobin subunit mu	Homo sapiens	3-7
31171361-1	2019	The transformation of hepatic stellate cells (HSCs) to activated myofibroblasts plays a critical role in the progression of hepatic fibrosis, while iron-catalyzed production of free radical, including reaction and active oxygen (ROS), and activation and transformation of HSC into a myofibroblasts has been regarded as a major mechanism.	Oxygen	221-227	fucosyltransferase 1 (H blood group)	Homo sapiens	46-49
31140479-2	2019	The in situ SERS results reveal that the tensile strain in the Pd shell could promote the activation of oxygen, thus improving the activity.	Oxygen	104-110	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	12-16
31337753-0	2019	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1alpha and HIF2alpha.	Oxygen	22-28	endothelial PAS domain protein 1	Homo sapiens	103-112
31184473-6	2019	As a result, the Ti-substituted NCA cathode exhibits impressive reversible capacity (198 mA h g-1 at 0.1C) with considerable cycle stability under a cutoff voltage up to 4.7 V. It is also revealed that Ti could suppress oxygen release in the high-voltage region, benefitting cycle and thermal stabilities.	Oxygen	220-226	CEA cell adhesion molecule 6	Homo sapiens	32-35
31149809-3	2019	In this paper, we provide a facile reduction method to modulate oxygen vacancy concentrations in oxide SERS substrates.	Oxygen	64-70	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	103-107
31149809-4	2019	Using MoO2 as an example, the resonance coupling as well as charge transfer between the semiconductor oxide SERS substrate and the target molecules were promoted for the reason of artificial oxygen vacancy embodied in the Raman signals being improved.	Oxygen	191-197	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	108-112
30395227-2	2019	To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable form of HIF-1alpha can be inducibly expressed in cardiac myocytes, under the regulation of tetracycline.	Oxygen	79-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
30395227-9	2019	Using mouse primary cells and cell lines, we show that transfection with oxygen-stable HIF-1alpha and PRKCBP1 reduced expression of direct HIF-1 gene targets and that knockdown of PRKCBP1 removes that negative inhibition.	Oxygen	73-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	87-97
30395227-9	2019	Using mouse primary cells and cell lines, we show that transfection with oxygen-stable HIF-1alpha and PRKCBP1 reduced expression of direct HIF-1 gene targets and that knockdown of PRKCBP1 removes that negative inhibition.	Oxygen	73-79	zinc finger, MYND-type containing 8	Mus musculus	180-187
30395227-10	2019	Consistent with previous reports suggesting that PRKCBP1 modulates the chromatin landscape, we found that HL-1 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1 have reduced global 5-methyl cytosine compared to HIF-1 alone.	Oxygen	134-140	zinc finger, MYND-type containing 8	Mus musculus	49-56
30395227-10	2019	Consistent with previous reports suggesting that PRKCBP1 modulates the chromatin landscape, we found that HL-1 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1 have reduced global 5-methyl cytosine compared to HIF-1 alone.	Oxygen	134-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	148-158
30993872-5	2019	Functionally, a decrease in oxygen consumption rate, a reduced citrate synthase activity, a drop in membrane potential, and an associated misbalanced mitochondrial function were observed exclusively in MET inhibitor-sensitive cells.	Oxygen	28-34	SAFB like transcription modulator	Homo sapiens	202-205
31050183-3	2019	TCTN2 was down-regulated in the spinal cord tissues of a rat model of SCI and in oxygen-glucose deprivation-induced hypoxic SY-SH-5Y cells, while microRNA-216b (miR-216b) was up-regulated.	Oxygen	81-87	tectonic family member 2	Rattus norvegicus	0-5
30597572-4	2019	Interestingly, we found that the interaction of BIN2 and BES1 was oxygen-dependent, and oxygen can directly modify BIN2.	Oxygen	66-72	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	57-61
31353834-7	2019	Like the linear relationship between V    O2 and work rate in CE CPET, V    O2 increased linearly with TM VIM.	Oxygen	76-78	vimentin	Homo sapiens	106-109
30882866-3	2019	Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type.	Oxygen	64-70	glutamate dehydrogenase 1	Arabidopsis thaliana	89-114
30882866-3	2019	Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type.	Oxygen	64-70	glutamate dehydrogenase 1	Arabidopsis thaliana	116-120
30882866-4	2019	Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the low-oxygen sensitivity of the stop1 mutant.	Oxygen	49-55	glutamate dehydrogenase 1	Arabidopsis thaliana	19-27
30882866-4	2019	Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the low-oxygen sensitivity of the stop1 mutant.	Oxygen	102-108	glutamate dehydrogenase 1	Arabidopsis thaliana	19-27
30882866-8	2019	Similar STOP1-dependent low-oxygen sensitivity was detected in tobacco.	Oxygen	28-34	protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like	Nicotiana tabacum	8-13
30882866-9	2019	Suppression of NtSTOP1 induced low-oxygen sensitivity, which was associated with lower expression levels of NtHsfA2 and NtGDHs compared with the wild-type.	Oxygen	35-41	protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like	Nicotiana tabacum	15-22
30882866-10	2019	Our results indicated that STOP1 pleiotropically regulates low-oxygen tolerance by transcriptional regulation.	Oxygen	63-69	protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like	Nicotiana tabacum	27-32
31020771-3	2019	In 1 m KOH solution, the optimized NCF catalysts show a low overpotential of 230 mV for the oxygen evolution reaction (OER) at a current density of 10 mA cm-2 with a low Tafel slope of 34.3 mV dec-1 , indicating fast and efficient OER kinetics.	Oxygen	92-98	neutrophil cytosolic factor 4	Homo sapiens	35-38
31318612-4	2019	In contrast, DCS-derived tissue O2 saturation decreased progressively with each incremental stage (P &lt; 0.01), driven almost entirely by an initial steep rise in deoxyhemoglobin/myoglobin, followed by a linear increase thereafter.	Oxygen	32-34	myoglobin	Homo sapiens	180-189
31344397-1	2019	Hypoxia inducible factor-1alpha (HIF-1alpha) is a key transcription factor that maintains oxygen homeostasis.	Oxygen	90-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
31344397-1	2019	Hypoxia inducible factor-1alpha (HIF-1alpha) is a key transcription factor that maintains oxygen homeostasis.	Oxygen	90-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
31328875-0	2019	Bio-Derived Co2 P Nanoparticles Supported on Nitrogen-Doped Carbon as Promising Oxygen Reduction Reaction Electrocatalyst for Anion Exchange Membrane Fuel Cells.	Oxygen	80-86	complement C2	Homo sapiens	12-15
2040698-3	1991	During continuous exposure to oxygen, both control and transgenic animals who successfully adapted to hyperoxia showed increased activity of lung antioxidant enzymes such as glutathione peroxidase (GPX), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PD), whereas superoxide dismutase activity remained unchanged.	Oxygen	30-36	glutathione reductase	Mus musculus	204-225
31411185-11	2019	Furthermore, pro-inflammatory cytokines IL-1ss, IL-6, and TNF-alpha were inhibited and anti-inflammatory cytokines IL-10 was increased in the lungs of rats in O2+Ad-hBD2 group.	Oxygen	159-162	interleukin 10	Rattus norvegicus	115-120
30981028-1	2019	In this work, the ZnO nanostars with excellent catalytic performance were firstly used as the coreaction accelerator of luminol-O2 system to construct a biosensor for ultrasensitively detecting microRNA-21 (miRNA-21) in cancer cells.	Oxygen	128-130	microRNA 21	Homo sapiens	194-205
30981028-1	2019	In this work, the ZnO nanostars with excellent catalytic performance were firstly used as the coreaction accelerator of luminol-O2 system to construct a biosensor for ultrasensitively detecting microRNA-21 (miRNA-21) in cancer cells.	Oxygen	128-130	microRNA 21	Homo sapiens	207-215
2040698-3	1991	During continuous exposure to oxygen, both control and transgenic animals who successfully adapted to hyperoxia showed increased activity of lung antioxidant enzymes such as glutathione peroxidase (GPX), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PD), whereas superoxide dismutase activity remained unchanged.	Oxygen	30-36	glutathione reductase	Mus musculus	227-229
30981028-4	2019	Moreover, upon the addition of a tiny minority of target miRNA-21, massive ferrocene (Fc) could be immobilized on the sensing interface through hybridization chain reaction (HCR) triggered-DNA dendrimers self-assembly, in which Fc consumed dissolved O2 for prominently quenching the ECL emission of signal probe and then reached a "signal off" state.	Oxygen	250-252	microRNA 21	Homo sapiens	57-65
31428461-7	2019	Consistent with the observations obtained from in vivo work, our in vitro study utilizing cultured neurons subjected to oxygen/glucose deprivation and reperfusion (OGD/R) also indicated that Sirt1 knockdown increased OGD/R-induced neuron necrosis and apoptosis, which was accompanied by decreased autophagic flux and increased p-P53.	Oxygen	120-126	sirtuin 1	Mus musculus	191-196
2040354-4	1991	Both series of patients showed a sustained doubling of the mean arterial/alveolar oxygen tension ratio (a/APO2) after treatment with surfactant.	Oxygen	82-88	TNF receptor superfamily member 10a	Homo sapiens	106-110
30690929-7	2019	The study demonstrated a correlation between venular retinal blood oxygen saturation and proangiogenic factors HGF (r = 0.558, p = 0.038), Ang2 (r = 0.556, p = 0.039) and EGF (r = -0.554, p = 0.040), but did not find any correlation for IL-8 (r = 0.330, p = 0.249) even though this biomarker was significantly higher in the diabetic group.	Oxygen	67-73	epidermal growth factor	Homo sapiens	171-174
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Oxygen	136-142	folliculin	Homo sapiens	62-66
31267382-9	2019	Similarly, the phosphorylation of FoxO1 decreased and the autophagy-related LC3-II was overexpressed with 4% O2 and CoCl2 conditions.	Oxygen	109-111	forkhead box O1	Mus musculus	34-39
31178586-10	2019	Levels of O2- were upregulated and H2O2 was slightly down-regulated by miR-378a.	Oxygen	10-13	microRNA 378a	Homo sapiens	71-79
31139773-0	2019	Oxygen deficiency introduced to Z-scheme CdS/WO3-x nanomaterials with MoS2 as the cocatalyst towards enhancing visible-light-driven hydrogen evolution.	Oxygen	0-6	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
31139773-1	2019	An oxygen deficiency modified Z-scheme CdS/WO3-x nanohybrid with MoS2 as the cocatalyst was synthesized by a microwave hydrothermal method and was used for photocatalytic hydrogen production under visible light irradiation.	Oxygen	3-9	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
31528849-7	2019	The primary outcome was the lowest level of end-tidal oxygen concentration (EtO2) within 2 min after intubation.	Oxygen	54-60	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	76-80
2040354-6	1991	High fraction of inspired oxygen requirement at entry had a negative impact on a/APO2 6 h and 24 h after treatment.	Oxygen	26-32	TNF receptor superfamily member 10a	Homo sapiens	81-85
30827134-1	2019	Aims: Adaptation to low oxygen of hematopoietic stem cells (HSCs) in the bone marrow has been demonstrated to depend on the activation of hypoxia-inducible factor (HIF)-1alpha as well as the limited production of reactive oxygen species (ROS).	Oxygen	24-30	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-175
1999425-2	1991	SOD-1- strains are unable to grow in 100% O2 in rich medium and are methionine and lysine auxotrophic when grown in air (Bilinski, T., Krawiec, Z., Liczmanski, A., and Litwinska, J.	Oxygen	42-44	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	0-5
31244122-2	2019	In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H   O.	Oxygen	162-168	complement C2	Homo sapiens	64-71
30571144-7	2019	Genetic deletion of carnitine palmitoyltransferase 1a (Cpt1a), a rate-limiting enzyme for carnitine shuttle, further augmented O2/rec-induced apoptosis.	Oxygen	127-129	carnitine palmitoyltransferase 1a, liver	Mus musculus	55-60
30571144-13	2019	Similarly, arrested alveolarization and reduced vessel numbers were further augmented in EC-specific Cpt1a-knockout mice compared with wild-type littermates in response to O2/rec.	Oxygen	172-174	carnitine palmitoyltransferase 1a, liver	Mus musculus	101-106
31244122-2	2019	In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H   O.	Oxygen	249-255	complement C2	Homo sapiens	64-71
1907074-4	1991	Thyrotropin-releasing hormone (200 micrograms, 400 micrograms intravenous) initiated a rapid short lasting rise of minute volume, ventilatory air-flow and alveolar oxygen tension under steady state breathing (P less than 0.001).	Oxygen	164-170	thyrotropin releasing hormone	Homo sapiens	0-29
31353704-5	2019	The hormesis effect of H2 O2 on PAC1-R promoter would help to further clarify the physiological effect of low-dose reactive oxygen on nervous system.	Oxygen	124-130	ADCYAP receptor type I	Homo sapiens	32-38
31353704-9	2019	The activation of PAC1-R promoter by low concentration of H2 O2 would help to further clarify the physiological effect of low-dose reactive oxygen on nervous system.	Oxygen	140-146	ADCYAP receptor type I	Homo sapiens	18-24
30223723-7	2019	Interestingly, when BeWo-immortalized placental trophoblast cells were cultured in oxygen concentrations mimicking healthy and ischemic placentas, there was a significant increase in acetylated at K9, K18, K27, and K56.	Oxygen	83-89	keratin 18	Homo sapiens	201-204
31108461-0	2019	IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels.	Oxygen	96-102	interleukin 1 alpha	Homo sapiens	0-9
31108461-0	2019	IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels.	Oxygen	96-102	hepcidin antimicrobial peptide	Homo sapiens	63-71
31108461-6	2019	In contrast, co-culture of differentiated macrophages with Huh7 cells significantly induced hepatocyte hepcidin, which was further potentiated under low oxygen levels.	Oxygen	153-159	hepcidin antimicrobial peptide	Homo sapiens	103-111
1996664-7	1991	Exposure of adult rats to 95% O2 resulted in a five- to sixfold induction of ceruloplasmin mRNA in lung tissue within 46 h, and this response was time dependent, reaching maximum values at 86 h. Hyperoxic induction of ceruloplasmin mRNA was specific to the lung and not the result of systemic inflammation because hepatic ceruloplasmin mRNA content remained constant.	Oxygen	30-32	ceruloplasmin	Rattus norvegicus	218-231
31108461-13	2019	Our data highlight a hitherto unrecognized role of macrophage-hepatocyte crosstalk for a joint and oxygen-dependent hepcidin production through STAT3 and CEBPdelta.	Oxygen	99-105	hepcidin antimicrobial peptide	Homo sapiens	116-124
31067491-11	2019	This study indicates that P4-PGRMC1 signaling caused a rapid increase in glycolysis in the presence of oxygen (aerobic glycolysis) and a corresponding decrease in cellular respiration, known as the Warburg effect.	Oxygen	103-109	progesterone receptor membrane component 1	Homo sapiens	29-35
1996664-7	1991	Exposure of adult rats to 95% O2 resulted in a five- to sixfold induction of ceruloplasmin mRNA in lung tissue within 46 h, and this response was time dependent, reaching maximum values at 86 h. Hyperoxic induction of ceruloplasmin mRNA was specific to the lung and not the result of systemic inflammation because hepatic ceruloplasmin mRNA content remained constant.	Oxygen	30-32	ceruloplasmin	Rattus norvegicus	218-231
2054736-1	1991	Our previous investigations have shown that endothelin-1 (ET-1) is a singularly potent constrictor of the ductus arteriosus and that a cytochrome P-450 system located in the sarcolemma is crucial for the contractile response of the vessel to oxygen.	Oxygen	242-248	EDN1	Ovis aries	44-56
31180628-0	2019	Tip-Induced Control of Charge and Molecular Bonding of Oxygen Atoms on the Rutile TiO2 (110) Surface with Atomic Force Microscopy.	Oxygen	55-61	TOR signaling pathway regulator	Homo sapiens	0-3
31180628-3	2019	We demonstrate a complete control over the oxygen species not attainable previously, allowing us to deliberately discriminate in favor of charge or bond manipulation, using either direct charge injection/removal through the tip-oxygen adatom junction or indirectly via polarons.	Oxygen	43-49	TOR signaling pathway regulator	Homo sapiens	224-227
31180628-3	2019	We demonstrate a complete control over the oxygen species not attainable previously, allowing us to deliberately discriminate in favor of charge or bond manipulation, using either direct charge injection/removal through the tip-oxygen adatom junction or indirectly via polarons.	Oxygen	228-234	TOR signaling pathway regulator	Homo sapiens	224-227
31140808-8	2019	At the transition state, the first peak of the solvent distribution near the oxygen atom in MVK is slightly closer for the endo pathway than that for the exo pathway, whereas the difference at PM6 level is negligible.	Oxygen	77-83	mannosidase endo-alpha	Homo sapiens	123-127
31206022-4	2019	Disruption of the BAP31-Tom40 complex inhibits mitochondrial complex I activity and oxygen consumption by the decreased NDUFS4 localization to the mitochondria.	Oxygen	84-90	B cell receptor associated protein 31	Homo sapiens	18-23
31138815-7	2019	Blocking ENDOA2-mediated endothelial cell migration attenuates pathological angiogenesis in oxygen-induced retinopathy models.	Oxygen	92-98	SH3-domain GRB2-like 1	Mus musculus	9-15
30950275-1	2019	Pd(PPh3)2Cl2-catalyzed selective tandem cyclization/oxidation of available conjugated diazo ene-yne-ketones under O2 atmosphere led to the formation of diazo trisubstituted furans.	Oxygen	114-116	protein phosphatase 4 catalytic subunit	Homo sapiens	3-7
30084650-6	2019	Administration of the HO-1 inducer cobalt protoporphyrin-IX significantly hindered Hhcy-augmented reactive oxygen species production and renal fibrotic lesions.	Oxygen	107-113	heme oxygenase 1	Homo sapiens	22-26
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Oxygen	47-49	mutS homolog 6	Homo sapiens	90-94
2054736-1	1991	Our previous investigations have shown that endothelin-1 (ET-1) is a singularly potent constrictor of the ductus arteriosus and that a cytochrome P-450 system located in the sarcolemma is crucial for the contractile response of the vessel to oxygen.	Oxygen	242-248	EDN1	Ovis aries	58-62
31397596-0	2019	Hb Alcorn County: A beta-Globin Variant [beta40(C6)Arg Thr; HBB: c.122G&gt;C (p.Arg41Thr)] with Increased Oxygen Affinity.	Oxygen	106-112	hemoglobin subunit beta	Homo sapiens	60-63
31070451-10	2019	In vivo hypoxia exposure (10% O2) increased RUNX2 mRNA levels in mice lung and the aorta.	Oxygen	30-32	runt related transcription factor 2	Mus musculus	44-49
2054736-5	1991	Treatment with a CO mixture (CO/O2 ratio, 0.27) inhibited ET-1 release from intact and endothelium-denuded preparations.	Oxygen	32-34	EDN1	Ovis aries	58-62
31397596-3	2019	This amino acid substitution involves the alpha1beta2 contact and occurs at the same position as Hb Austin [beta40(C6)Arg Ser; HBB: c.[123G&gt;C or 123G&gt;T] (p.Arg41Ser)] and Hb Athens-GA [beta40(C6)Arg Lys; HBB: c.122G&gt;A (p.Arg41Lys)], both of which show increased oxygen affinity.	Oxygen	271-277	hemoglobin subunit beta	Homo sapiens	127-130
2054736-6	1991	We propose that oxygen triggers closure of the ductus arteriosus at birth by causing a conformational change in a specific cytochrome P-450, which, in turn, provides the signal for the synthesis of the constrictor ET-1.	Oxygen	16-22	EDN1	Ovis aries	214-218
2020021-6	1991	The AVP-induced coupling of K+ to the Na+:Cl- cotransporter resulted in a doubling in the rate of NaCl absorption without a parallel increase in the rate of cellular 22Na+ uptake or transport-related oxygen consumption.	Oxygen	200-206	arginine vasopressin	Mus musculus	4-7
31043649-3	2019	Since Hp:Hb complexes show heme-based reactivity, kinetics of O2 dissociation from the ferrous oxygenated human Hp1-1:Hb and Hp2-2:Hb complexes (Hp1-1:Hb(II)-O2 and Hp2-2:Hb(II)-O2, respectively) have been determined.	Oxygen	62-64	chromobox 5	Homo sapiens	112-115
31043649-3	2019	Since Hp:Hb complexes show heme-based reactivity, kinetics of O2 dissociation from the ferrous oxygenated human Hp1-1:Hb and Hp2-2:Hb complexes (Hp1-1:Hb(II)-O2 and Hp2-2:Hb(II)-O2, respectively) have been determined.	Oxygen	62-64	chromobox 5	Homo sapiens	145-148
31043649-4	2019	O2 dissociation from Hp1-1:Hb(II)-O2 and Hp2-2:Hb(III)-O2 follows a biphasic process.	Oxygen	0-2	chromobox 5	Homo sapiens	21-26
30939409-3	2019	Herein, a multi-functional nanoplatform is rationally constructed by fluorinated polymer nanoparticle saturated with oxygen in advance, which simultaneously encapsulated PS (Ce6) and an indoleamine 2,3-dioxygenase (IDO) inhibitor (NLG919).	Oxygen	117-123	indoleamine 2,3-dioxygenase 1	Homo sapiens	186-213
30939409-3	2019	Herein, a multi-functional nanoplatform is rationally constructed by fluorinated polymer nanoparticle saturated with oxygen in advance, which simultaneously encapsulated PS (Ce6) and an indoleamine 2,3-dioxygenase (IDO) inhibitor (NLG919).	Oxygen	117-123	indoleamine 2,3-dioxygenase 1	Homo sapiens	215-218
30635935-6	2019	Our results showed that overexpression of GDF15 significantly reversed the cells viability, oxygen consumption, and mitochondrial membrane potential effect caused by oligomycin in HT22 cells.	Oxygen	92-98	growth differentiation factor 15	Mus musculus	42-47
1899285-1	1991	Superoxide dismutases (SOD) play a major role in the intracellular defense against oxygen radical damage to aerobic cells.	Oxygen	83-89	Superoxide dismutase 1	Drosophila melanogaster	0-21
31114503-9	2019	After the physical activity intervention PCSK9 levels were even stronger inversely associated with maximal oxygen uptake (R = -0.410, p = 0.0008) and positively correlated with HDL cholesterol (R = 0.264, p = 0.030).	Oxygen	107-113	proprotein convertase subtilisin/kexin type 9	Homo sapiens	41-46
1899285-1	1991	Superoxide dismutases (SOD) play a major role in the intracellular defense against oxygen radical damage to aerobic cells.	Oxygen	83-89	Superoxide dismutase 1	Drosophila melanogaster	23-26
31114506-10	2019	Yet, supplied with the complex II substrate succinate, mitochondria of Mecp2-/y cortex and hippocampus consumed more O2 than WT.	Oxygen	117-119	methyl CpG binding protein 2	Mus musculus	71-76
30825821-3	2019	The results indicated that chemical oxygen demand (COD) was increased by SAR2 treatment and COD removal efficiency for SBBR, SAR1 and STR was 39.7%, 15.7% and 30.9% respectively.	Oxygen	36-42	secretion associated Ras related GTPase 1A	Homo sapiens	125-129
1899285-2	1991	In eucaryotes, the cytoplasmic form of the enzyme is a 32-kDa dimer containing two copper and two zinc atoms (CuZn SOD) that catalyzes the dismutation of the superoxide anion (O2-) to H2O2 and O2.	Oxygen	176-178	Superoxide dismutase 1	Drosophila melanogaster	110-118
30260337-3	1991	The introduction of a C-6 phosphate group to D-glucosamine or the simultaneous use of phosphate ion and D-glucosamine heightened the original activity of D-glucosamine to generate these oxygens, especially OH.	Oxygen	186-193	complement C6	Homo sapiens	22-25
31281527-10	2019	At the same time, the hyperthermia generated by MoS2 could synergistically improve the PDT effect with the acceleration of the blood flow, leading to the increase of the oxygen level in tumor tissue.	Oxygen	170-176	mago homolog, exon junction complex core component	Mus musculus	48-52
30907907-5	2019	Concerning the reactive species scavenging capacity, the extract was more effective against O2 -, HClO and  NO (namely, IC50 = 17.24 +- 0.24 mug mL-1, IC50 = 9.25 +- 0.92 mug mL-1 and IC50 = 0.65 +- 0.06 mug mL-1).	Oxygen	92-94	L1 cell adhesion molecule	Mus musculus	145-149
2229044-0	1990	Thermodynamic study of protein dynamic structure in the oxygen binding reaction of myoglobin.	Oxygen	56-62	myoglobin	Physeter catodon	83-92
30910827-7	2019	We propose that in normal development, oxygen from nascent retinal vasculature triggers PHD2-dependent HIF-2alpha degradation in nearby astrocytic precursors, thus limiting their further growth by driving them to differentiate into non-proliferative mature astrocytes.	Oxygen	39-45	egl-9 family hypoxia-inducible factor 1	Mus musculus	88-92
30910827-7	2019	We propose that in normal development, oxygen from nascent retinal vasculature triggers PHD2-dependent HIF-2alpha degradation in nearby astrocytic precursors, thus limiting their further growth by driving them to differentiate into non-proliferative mature astrocytes.	Oxygen	39-45	endothelial PAS domain protein 1	Mus musculus	103-113
30962349-2	2019	Its inducible subunit, HIF-2alpha (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as phosphorylation.	Oxygen	74-80	endothelial PAS domain protein 1	Homo sapiens	23-33
30962349-2	2019	Its inducible subunit, HIF-2alpha (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as phosphorylation.	Oxygen	74-80	endothelial PAS domain protein 1	Homo sapiens	49-54
30962349-2	2019	Its inducible subunit, HIF-2alpha (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as phosphorylation.	Oxygen	102-108	endothelial PAS domain protein 1	Homo sapiens	23-33
30962349-2	2019	Its inducible subunit, HIF-2alpha (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as phosphorylation.	Oxygen	102-108	endothelial PAS domain protein 1	Homo sapiens	49-54
30962349-3	2019	We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays.	Oxygen	65-67	endothelial PAS domain protein 1	Homo sapiens	18-28
30990023-3	2019	The intercalation of the alkali metal ion (Na+) and the increase of the surface terminal oxygen-fluorine ratio ([O]/[F]) in Ti3C2T x can effectively improve humidity- and gas-sensing properties at room temperature.	Oxygen	89-95	gastrin	Homo sapiens	171-174
31126994-8	2019	This regulatory network formed by the NOTCH, hypoxia, and RAS/MAPK pathways may allow the animals to adapt developmental processes to variations in oxygen concentration.	Oxygen	148-154	lin-12/Notch intracellular domain	Caenorhabditis elegans	38-43
31240212-0	2019	Role of TGF-Beta1/SMAD2/3 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 50/10 Oxygen-Induced Retinopathy.	Oxygen	110-116	SMAD family member 2	Rattus norvegicus	18-25
2176255-2	1990	Cells were exposed to reactive oxygen molecules including superoxide anion, hydrogen peroxide and hydroxyl radical generated by xanthine oxidase and hypoxanthine.	Oxygen	31-37	xanthine dehydrogenase	Sus scrofa	128-144
31091718-3	2019	Genetic mosaicism of gain-of-function mutations of the EPAS1 gene (encoding HIF2alpha) located in the oxygen degradation domain (ODD), typically p.530-532, was shown as the etiology of this syndrome.	Oxygen	102-108	endothelial PAS domain protein 1	Mus musculus	55-60
31091718-3	2019	Genetic mosaicism of gain-of-function mutations of the EPAS1 gene (encoding HIF2alpha) located in the oxygen degradation domain (ODD), typically p.530-532, was shown as the etiology of this syndrome.	Oxygen	102-108	endothelial PAS domain protein 1	Mus musculus	76-85
30959909-7	2019	We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1).	Oxygen	29-35	collagen type III alpha 1 chain	Homo sapiens	165-171
30959909-9	2019	We found TGF-beta receptors ALK1 and ALK5 to be regulated by oxygen tension on the mRNA and protein level.	Oxygen	61-67	activin A receptor like type 1	Homo sapiens	28-32
30959909-9	2019	We found TGF-beta receptors ALK1 and ALK5 to be regulated by oxygen tension on the mRNA and protein level.	Oxygen	61-67	transforming growth factor beta receptor 1	Homo sapiens	37-41
30959909-10	2019	In addition, expression of type III co-receptors betaglycan and endoglin appeared to be regulated by oxygen tension as well.	Oxygen	101-107	endoglin	Homo sapiens	64-72
30803063-3	2019	The as-prepared single atoms, supported by N-doped carbon flake arrays grown on carbon nanofibers assembly (M SA@NCF/CNF), demonstrate the dual characteristics of excellent catalytic activity (reversible oxygen overpotential of 0.75 V) and high stability, owing to the greatly improved active sites" accessibility and optimized single-sites/pore-structures correlations.	Oxygen	204-210	neutrophil cytosolic factor 4	Homo sapiens	113-116
2173592-1	1990	Heart lipoamide dehydrogenase (LADH) catalyzed redox-cycling and O2-.	Oxygen	65-67	dihydrolipoamide dehydrogenase	Homo sapiens	6-29
29955959-7	2019	The model also predicts that the [Formula: see text] transport load and thus oxygen consumption of the S3 segment are increased under SGLT2 inhibition, a consequence that may increase the risk of hypoxia for that segment.	Oxygen	77-83	solute carrier family 5 member 2	Homo sapiens	134-139
30875426-8	2019	CONCLUSIONS: This study demonstrates for the first time that long-term administration of acetylcholinesterase inhibitors, pyridostigmine or donepezil, attenuates vascular reactivity dysfunction in SHR by decreasing reactive oxygen species generation and increasing NO bioavailability; possibly via increased endothelial NO synthase activity, and inhibition of NADPH oxidase activity.	Oxygen	224-230	acetylcholinesterase	Rattus norvegicus	89-109
30773021-8	2019	Furthermore, SAHH inhibition induced production of reactive oxygen species and p66shc expression in the mouse aorta and human aortic endothelial cells.	Oxygen	60-66	S-adenosylhomocysteine hydrolase	Mus musculus	13-17
2173592-1	1990	Heart lipoamide dehydrogenase (LADH) catalyzed redox-cycling and O2-.	Oxygen	65-67	dihydrolipoamide dehydrogenase	Homo sapiens	31-35
30773021-9	2019	Antioxidants and p66shc siRNA prevented SAHH inhibition-induced generation of reactive oxygen species and attenuated the impaired endothelial vasomotor responses in high-SAH mice.	Oxygen	87-93	S-adenosylhomocysteine hydrolase	Mus musculus	40-44
29955959-9	2019	The model predicts that the optimal combination of SGLT2/SGLT1 inhibition lowers the oxygen requirements of key tubular segments, but decreases urine flow and [Formula: see text] excretion; the latter effect may limit the cardiovascular protection of the treatment.	Oxygen	85-91	solute carrier family 5 member 2	Homo sapiens	51-56
2176270-3	1990	Purified rat h-FABP at 40 microM scavenged as much as 30% O2- and 85% OH.. On the other hand, when 2 nmol (4 microM) FABP were exposed to free radicals, the maximum oleate binding capacity as measured by Scatchard analysis was reduced only by 14% and 27% for O2- and OH., respectively.	Oxygen	58-60	fatty acid binding protein 3	Rattus norvegicus	13-19
2176270-3	1990	Purified rat h-FABP at 40 microM scavenged as much as 30% O2- and 85% OH.. On the other hand, when 2 nmol (4 microM) FABP were exposed to free radicals, the maximum oleate binding capacity as measured by Scatchard analysis was reduced only by 14% and 27% for O2- and OH., respectively.	Oxygen	259-261	fatty acid binding protein 3	Rattus norvegicus	13-19
2121051-2	1990	We determined whether direct generation of activated oxygen on the brain surface (OX: xanthine oxidase, hypoxanthine, FeCl3, and FeSO4) or topical arachidonate altered pial arteriolar responsiveness in a manner similarly to cerebral ischemia.	Oxygen	53-59	xanthine dehydrogenase	Sus scrofa	86-102
30804532-1	2019	Hypoxia-inducible factor-2 (HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive HIF-2alpha subunit and its obligate partner subunit ARNT.	Oxygen	114-120	endothelial PAS domain protein 1	Homo sapiens	131-141
30804532-1	2019	Hypoxia-inducible factor-2 (HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive HIF-2alpha subunit and its obligate partner subunit ARNT.	Oxygen	114-120	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	183-187
30948460-7	2019	This multi-tier regulation coordinated by ADAR1 promotes robust and timely accumulation of HIF-1alpha upon oxygen depletion and reinforces target gene induction and downstream angiogenesis.	Oxygen	107-113	adenosine deaminase RNA specific	Homo sapiens	42-47
30721625-6	2019	In response to running exercise, however, the Fndc5 mutant mice exhibit reduced glucose tolerance and insulin sensitivity and have lower maximal oxygen consumption compared with the exercised wild-type mice.	Oxygen	145-151	fibronectin type III domain containing 5	Mus musculus	46-51
30417335-9	2019	Furthermore, silencing of miR-382-5p reduced basal oxygen consumption rate by 14% ( p &lt; 0.05) without affecting mitochondrial content, pointing towards a more efficient mitochondrial function as a result of improved mitochondrial quality control.	Oxygen	51-57	microRNA 382	Homo sapiens	26-33
30815655-0	2019	Unbridged Rh(ii)-Rh(ii) complexes of N-heterocyclic carbenes and reactions with O2 to form dirhodium(mu-eta1:eta1-O2) complexes.	Oxygen	80-82	Rh blood group D antigen	Homo sapiens	10-16
30815655-0	2019	Unbridged Rh(ii)-Rh(ii) complexes of N-heterocyclic carbenes and reactions with O2 to form dirhodium(mu-eta1:eta1-O2) complexes.	Oxygen	80-82	Rh blood group D antigen	Homo sapiens	17-23
30815655-0	2019	Unbridged Rh(ii)-Rh(ii) complexes of N-heterocyclic carbenes and reactions with O2 to form dirhodium(mu-eta1:eta1-O2) complexes.	Oxygen	80-82	secreted phosphoprotein 1	Homo sapiens	104-108
30815655-0	2019	Unbridged Rh(ii)-Rh(ii) complexes of N-heterocyclic carbenes and reactions with O2 to form dirhodium(mu-eta1:eta1-O2) complexes.	Oxygen	80-82	secreted phosphoprotein 1	Homo sapiens	109-113
1370026-5	1990	Volumetric Von Willebrand factor productivity was influenced by oxygen concentration, and remained stable during scale-up from 1 to 10 liter fermentors.	Oxygen	64-70	von Willebrand factor	Cricetulus griseus	11-32
30782782-0	2019	Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.	Oxygen	27-33	ATM serine/threonine kinase	Homo sapiens	23-26
30475644-9	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	toll like receptor 4	Homo sapiens	8-12
31052261-3	2019	CAR-T cells expanded to a much lower extent in 1% oxygen than in 18% oxygen.	Oxygen	50-56	CXADR pseudogene 1	Homo sapiens	0-3
31052261-6	2019	Atmospheric and hypoxic CAR-T cells exhibited comparable cytolytic activity and PD-1 upregulation; however, cytokine production and granzyme B release were greatly decreased in 1% oxygen, even when the CAR-T cells were generated in atmospheric culture.	Oxygen	180-186	CXADR pseudogene 1	Homo sapiens	24-27
31052261-6	2019	Atmospheric and hypoxic CAR-T cells exhibited comparable cytolytic activity and PD-1 upregulation; however, cytokine production and granzyme B release were greatly decreased in 1% oxygen, even when the CAR-T cells were generated in atmospheric culture.	Oxygen	180-186	granzyme B	Homo sapiens	132-142
31052261-6	2019	Atmospheric and hypoxic CAR-T cells exhibited comparable cytolytic activity and PD-1 upregulation; however, cytokine production and granzyme B release were greatly decreased in 1% oxygen, even when the CAR-T cells were generated in atmospheric culture.	Oxygen	180-186	CXADR pseudogene 1	Homo sapiens	202-205
31052261-7	2019	Together, these data show that at solid tumor oxygen levels, CAR-T cells are impaired in expansion, differentiation and cytokine production.	Oxygen	46-52	CXADR pseudogene 1	Homo sapiens	61-64
2387845-0	1990	Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type.	Oxygen	84-86	xanthine dehydrogenase	Rattus norvegicus	26-48
31035592-3	2019	LDHA has a higher affinity for pyruvate, preferentially converting pyruvate to lactate, and NADH to NAD+ in anaerobic conditions, whereas LDHB possess a higher affinity for lactate, preferentially converting lactate to pyruvate, and NAD+ to NADH, when oxygen is abundant.	Oxygen	252-258	lactate dehydrogenase B	Homo sapiens	138-142
31182989-7	2019	By dihydroethidium (DHE) staining and electron spin resonance (ESR) assays, we demonstrated that CyPA reduced ROS production and suppressed O2 - production dependent on reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.	Oxygen	140-142	peptidylprolyl isomerase A	Homo sapiens	97-101
30791543-2	2019	Hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor that is up-regulated in response to reduced oxygen during bone repair, is known to mediate angiogenesis and osteogenesis.	Oxygen	113-119	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
30791543-2	2019	Hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor that is up-regulated in response to reduced oxygen during bone repair, is known to mediate angiogenesis and osteogenesis.	Oxygen	113-119	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
30783096-5	2019	PD-L1 signaling, which is associated with activation of the MAPK pathway and increased mitochondrial oxygen consumption, is reversed by PD-1 blockade.	Oxygen	101-107	CD274 molecule	Homo sapiens	0-5
2335990-0	1990	Home oxygen--a revolution in the care of advanced COPD.	Oxygen	5-11	COPD	Homo sapiens	50-54
30783090-5	2019	Furthermore, endothelial MST1-FOXO1 cascade is required for revascularization and neovascularization in the oxygen-induced retinopathy model.	Oxygen	108-114	forkhead box O1	Mus musculus	30-35
31015457-2	2019	Herein, we report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 (Pt1@MIL) induces distinct reaction path to improve selective hydrogenation of CO2 into methanol.	Oxygen	72-78	zinc finger protein 77	Homo sapiens	97-104
31015290-8	2019	ORAI1-deficient LS8 cells showed altered mitochondrial respiration with increased oxygen consumption rate and ATP, which was associated with altered redox status and enhanced ER Ca2+ uptake, likely due to S-glutathionylation of SERCA pumps.	Oxygen	82-88	ORAI calcium release-activated calcium modulator 1	Mus musculus	0-5
2335990-2	1990	Oxygen is established as not only safe but effective in selected patients with advanced COPD.	Oxygen	0-6	COPD	Homo sapiens	88-92
2341345-0	1990	Tracheal insufflation of tumor necrosis factor protects rats against oxygen toxicity.	Oxygen	69-75	tumor necrosis factor-like	Rattus norvegicus	25-46
30988281-8	2019	TRAF2 expression and necroptosis were induced in mouse primary microglia treated with conditioned medium collected from neurons subject to oxygen and glucose deprivation (OGD) and in TNFalpha-treated mouse hippocampal neuronal HT-22 cells in the presence of the pan-caspase inhibitor Z-VAD.	Oxygen	139-145	TNF receptor-associated factor 2	Mus musculus	0-5
30920211-7	2019	The calculated adsorption energy, oxygen vacancy formation energy, and the free energy profiles show that the catalytic activity of Pd1/PTA, Rh1/PTA, and Pt1/PTA SACs is quite high, especially for Pt1/PTA and Pd1/PTA systems.	Oxygen	34-40	zinc finger protein 77	Homo sapiens	154-157
30640420-0	2019	Paper-Supported Self-Powered System Based on a Glucose/O2 Biofuel Cell for Visual MicroRNA-21 Sensing.	Oxygen	55-57	microRNA 21	Homo sapiens	82-93
30725321-3	2019	Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1alpha, HIF-2alpha, or both proteins.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	170-180
30725321-3	2019	Manipulating oxygen sensing machinery in osteogenic cells influences skeletal phenotype through angiogenesis-dependent and angiogenesis-independent pathways and involves HIF-1alpha, HIF-2alpha, or both proteins.	Oxygen	13-19	endothelial PAS domain protein 1	Mus musculus	182-192
2341345-1	1990	Tracheal insufflation of tumor necrosis factor (TNF; 5 micrograms or 1.2 x 10(5) U) markedly enhanced the survival of adult rats exposed to 100% O2: 12 of 17 rats (71%) survived for greater than 11 days, whereas 30 of 30 control (Hanks" balanced salt solution) insufflated rats (100%) died within 3 days of O2 exposure.	Oxygen	145-147	tumor necrosis factor-like	Rattus norvegicus	25-46
30502455-3	2019	Glutamate stimulation induced HK-II dissociation from mitochondria and impaired mitochondrial function, indicated by the opening of the mitochondrial permeability transition pore, the collapse of mitochondrial membrane potential and reduced mitochondrial oxygen consumption ratio in neurons.	Oxygen	255-261	hexokinase 2	Mus musculus	30-35
30849767-7	2019	Significant alternations in the expression levels of previously reported oxygen-sensitive surface proteins were detected in this study, some of which closely correlate with the expression levels of HIF2A.	Oxygen	73-79	endothelial PAS domain protein 1	Homo sapiens	198-203
32073578-0	2019	Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy.	Oxygen	126-132	hydroxyacid oxidase 1, liver	Mus musculus	0-15
2341345-1	1990	Tracheal insufflation of tumor necrosis factor (TNF; 5 micrograms or 1.2 x 10(5) U) markedly enhanced the survival of adult rats exposed to 100% O2: 12 of 17 rats (71%) survived for greater than 11 days, whereas 30 of 30 control (Hanks" balanced salt solution) insufflated rats (100%) died within 3 days of O2 exposure.	Oxygen	145-147	tumor necrosis factor-like	Rattus norvegicus	48-51
2341345-1	1990	Tracheal insufflation of tumor necrosis factor (TNF; 5 micrograms or 1.2 x 10(5) U) markedly enhanced the survival of adult rats exposed to 100% O2: 12 of 17 rats (71%) survived for greater than 11 days, whereas 30 of 30 control (Hanks" balanced salt solution) insufflated rats (100%) died within 3 days of O2 exposure.	Oxygen	307-309	tumor necrosis factor-like	Rattus norvegicus	25-46
30658115-3	2019	In the present study, we aimed to investigate the potential role and underlying mechanism of CKIP-1 in regulating neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation (OGD/R) treatment in vitro.	Oxygen	165-171	pleckstrin homology domain containing O1	Homo sapiens	93-99
30124960-8	2019	Conclusions: These data are consistent with the possibility that the decidua functions as a nutrient sensor linking limited oxygen and nutrient availability to increased IGFBP-1 phosphorylation, possibly mediated by mTOR and AAR signaling.	Oxygen	124-130	insulin like growth factor binding protein 1	Homo sapiens	170-177
2341345-1	1990	Tracheal insufflation of tumor necrosis factor (TNF; 5 micrograms or 1.2 x 10(5) U) markedly enhanced the survival of adult rats exposed to 100% O2: 12 of 17 rats (71%) survived for greater than 11 days, whereas 30 of 30 control (Hanks" balanced salt solution) insufflated rats (100%) died within 3 days of O2 exposure.	Oxygen	307-309	tumor necrosis factor-like	Rattus norvegicus	48-51
2298735-0	1990	New transient species of sperm whale myoglobin in photodissociation of dioxygen from oxymyoglobin.	Oxygen	71-79	myoglobin	Physeter catodon	37-46
30452097-0	2019	Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 1	Mus musculus	32-36
30746828-6	2019	We found that Tg-APP/PS1 mice treated with 100% O2 at increased atmospheric pressure in a chamber exhibited markedly reduced Abeta accumulation and hippocampal neuritic atrophy, increased hippocampal neurogenesis, and profoundly improved the cognitive deficits on the multiple behavioral test paradigms.	Oxygen	48-50	presenilin 1	Mus musculus	21-24
30746828-6	2019	We found that Tg-APP/PS1 mice treated with 100% O2 at increased atmospheric pressure in a chamber exhibited markedly reduced Abeta accumulation and hippocampal neuritic atrophy, increased hippocampal neurogenesis, and profoundly improved the cognitive deficits on the multiple behavioral test paradigms.	Oxygen	48-50	amyloid beta (A4) precursor protein	Mus musculus	125-130
2298735-2	1990	When the optical absorption spectral changes associated with the O2 rebinding were monitored on the nanosecond to millisecond time scale, we found that the transient spectra of the O2 photoproduct of sperm whale myoglobin were significantly different from the static spectra of deoxy form.	Oxygen	65-67	myoglobin	Physeter catodon	212-221
30476008-6	2019	In the maternal compartment, mTOR is an integral part of a decidual nutrient sensor which links oxygen and nutrient availability to the phosphorylation of IGFBP-1 with preferential effects on the bioavailability of IGF-I in the maternal-fetal interface and in the maternal circulation.	Oxygen	96-102	insulin like growth factor binding protein 1	Homo sapiens	155-162
30400060-3	2019	Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen.	Oxygen	240-246	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	148-188
30400060-3	2019	Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen.	Oxygen	240-246	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	190-193
2298735-2	1990	When the optical absorption spectral changes associated with the O2 rebinding were monitored on the nanosecond to millisecond time scale, we found that the transient spectra of the O2 photoproduct of sperm whale myoglobin were significantly different from the static spectra of deoxy form.	Oxygen	181-183	myoglobin	Physeter catodon	212-221
2298735-4	1990	These results led us to suggest the presence of a fairly stable transient species in the O2 photodissociation from the oxy complex of sperm whale myoglobin, which has a protein structure different from the deoxy form.	Oxygen	89-91	myoglobin	Physeter catodon	146-155
2298735-7	1990	The structure of Mb* is discussed in relation to the dynamic motion of myoglobin in the O2 entry to or exit from the heme pocket.	Oxygen	88-90	myoglobin	Physeter catodon	71-80
2101691-1	1990	We have identified and isolated cDNA clones of the 33 kDa protein of the oxygen-evolving complex (OEE1) from Lycopersicon esculentum (tomato) and Arabidopsis thaliana and determined their nucleotide sequences.	Oxygen	73-79	oxygen-evolving enhancer protein 1, chloroplastic	Solanum lycopersicum	98-102
30578869-5	2019	RESULTS: Passive movement of the right index finger and passive alternating right and left index finger movement resulted in a significant increase in blood-oxygen-level-dependent (BOLD) signal in contralateral SM1 cortex in 14/15 and 15/15 subjects respectively.	Oxygen	157-163	SM1	Homo sapiens	211-214
30940682-0	2019	BET 1: High-flow nasal oxygen therapy in bronchiolitis.	Oxygen	23-29	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	0-5
31104403-2	2019	Tissue hypoxia in malarial infection may increase the activity of HIF1alpha through an intracellular oxygen-sensing pathway.	Oxygen	101-107	hypoxia inducible factor 1, alpha subunit	Mus musculus	66-75
30289618-9	2019	HMGA2 increased mitochondrial oxygen consumption rate and spare respiratory capacity and increased NAMPT levels, suggesting metabolic support for enhanced PARP1 activity upon DNA damage.	Oxygen	30-36	high mobility group AT-hook 2	Homo sapiens	0-5
2096666-8	1990	Since electron microscopic immuno-gold labelling demonstrated the presence of this protein in the LSSL, and electrochemically it proved to transport lipids from the surface layer to the subphase, it was suggested that Sp-A plays the role of an oxygen carrier.	Oxygen	244-250	surfactant protein A1	Homo sapiens	218-222
30536571-5	2019	Hypoxia (1% O2 ) induced high expression of both HIF-1alpha and especially HIF-2alpha, and increased the resistance of OVCAR-3 S and CAOV-3 S cells to ADR.	Oxygen	12-14	endothelial PAS domain protein 1	Homo sapiens	75-85
30644464-3	2019	Structural studies reveal that oxygen vacancies tend to orderly align in PrO1-delta.	Oxygen	31-37	lamin A/C	Homo sapiens	73-77
30774414-0	2019	Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.	Oxygen	11-17	TSC complex subunit 2	Rattus norvegicus	56-60
30092282-10	2019	Metabolic studies showed a significant decrease in the extracellular acidification rate (ECAR) and mitochondrial oxygen consumption rate (OCR) and acidic pH in HuR-silenced NP cells, without appreciable change in total OCR.	Oxygen	113-119	ELAV like RNA binding protein 1	Homo sapiens	160-163
1965761-5	1990	(3) When about 30% of myoglobin was deoxygenated at both 35 degrees C and 15 degrees C, the oxygen uptake started to decrease and lactate release increased.	Oxygen	38-44	myoglobin	Rattus norvegicus	22-31
30668541-9	2019	Correspondingly, FH+/- cells showed a lower basal oxygen consumption rate (OCR) but a higher level of reactive oxygen species (ROS) production.	Oxygen	50-56	fumarate hydratase	Rattus norvegicus	17-19
1690958-0	1990	On the application of the Clark oxygen electrode to the study of enzyme kinetics in apolar solvents: the catalase reaction.	Oxygen	32-38	catalase	Bos taurus	105-113
30674873-8	2019	Furthermore, reduced oxygen availability increases GLS1 mRNA and protein expression, due to transcriptional activation by hypoxia-inducible factor 1.	Oxygen	21-27	glutaminase	Homo sapiens	51-55
30641857-8	2019	PON2-def mice had decreased oxygen consumption and energy expenditure.	Oxygen	28-34	paraoxonase 2	Mus musculus	0-4
33768716-0	2021	A Novel Perovskite Electron-Ion Conductive Coating to Simultaneously Enhance Cycling Stability and Rate Capability of Li1.2 Ni0.13 Co0.13 Mn0.54 O2 Cathode Material for Lithium-Ion Batteries.	Oxygen	145-147	transglutaminase 1	Homo sapiens	118-121
30641857-9	2019	Furthermore, the oxygen consumption rate of subcutaneous fat pads from PON2-def mice was lower compared to WT mice.	Oxygen	17-23	paraoxonase 2	Mus musculus	71-75
33768716-2	2021	Herein, a novel perovskite electron-ion mixed conductor Nd0.6 Sr0.4 CoO3 (NSCO) is used as the coating layer on Li1.2 Ni0.13 Co0.13 Mn0.54 O2 (LNCMO) to simultaneously enhance its cycling stability and rate capability.	Oxygen	139-141	transglutaminase 1	Homo sapiens	112-115
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Oxygen	119-125	ferritin mitochondrial	Homo sapiens	6-28
33811473-6	2021	METHODS: We evaluated multiple GBM cell lines to determine their relative sensitivity to oxygenation levels via measuring carbonic anhydrase IX (CAIX) levels, which is a surrogate marker for indirectly identifying hypoxia by reporting on oxygen deprivation levels and upregulated NTR activity.	Oxygen	89-95	carbonic anhydrase 9	Homo sapiens	122-143
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Oxygen	119-125	ferritin mitochondrial	Homo sapiens	39-43
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Oxygen	209-215	ferritin mitochondrial	Homo sapiens	6-28
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Oxygen	209-215	ferritin mitochondrial	Homo sapiens	39-43
29402144-7	2019	Conclusion: Thus, the cell ability to increase expression of FtMt during hypoxia may be a skill to avoid tissue damage derived from oxygen limitation.	Oxygen	132-138	ferritin mitochondrial	Homo sapiens	61-65
33793600-9	2021	RESULTS: Older age, higher temperature, increased respiratory rate (RR) and a lower oxygen saturation (SpO2) from the first set of vital signs were associated with an increased risk of MV amongst the 1980 patients in the ER.	Oxygen	84-90	epiregulin	Homo sapiens	221-223
30525531-2	2019	Specifically, we replaced one O2- in Ba3P3O10Cl by two Cl-, leading to the formation of a new compound of BaPO3Cl ( P21/ c).	Oxygen	30-32	H3 histone pseudogene 16	Homo sapiens	116-119
31562623-1	2019	The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	28-33
33799686-1	2021	Von Hippel Lindau (VHL) inactivation, which is common in clear cell renal cell carcinoma (ccRCC), leads directly to the disruption of oxygen homoeostasis.	Oxygen	134-140	von Hippel-Lindau tumor suppressor	Homo sapiens	0-17
33799686-1	2021	Von Hippel Lindau (VHL) inactivation, which is common in clear cell renal cell carcinoma (ccRCC), leads directly to the disruption of oxygen homoeostasis.	Oxygen	134-140	von Hippel-Lindau tumor suppressor	Homo sapiens	19-22
31699221-5	2019	Regarding the Hippo signaling in innate immunity, we have reported that Mst1/2 kinases are required for phagocytosis and efficient clearance of bacteria in phagocytes by regulating reactive oxygen species (ROS) production; and at the same time, by sensing the excessive ROS, Mst1/2 kinases maintain cellular redox homeostasis and prevent phagocytes aging and death through modulating the stability of the key antioxidant transcription factor Nrf2.	Oxygen	190-196	macrophage stimulating 1	Homo sapiens	72-78
33237298-13	2020	Our data suggest that aberrant Dio2/TH signaling is an important factor in the pathophysiology of the visual dysfunction observed in the oxygen-induced retinopathy model of ROP.	Oxygen	137-143	tyrosine hydroxylase	Mus musculus	36-38
30864470-0	2019	A cross sectional study to ascertain the incidence and causes of failure of oxygen delivery via Hudson Mask  during recovery after anaesthesia.	Oxygen	76-82	ankyrin repeat and KH domain containing 1	Homo sapiens	103-107
30907806-0	2019	Bioengineered Approach to the Design of a Fat Graft Based on Mathematical Modeling that Predicts Oxygen Delivery.	Oxygen	97-103	FAT atypical cadherin 1	Homo sapiens	42-45
29786072-6	2019	In primary microglia and mixed glial cell cultures, MPTP/ATP treatment promotes the robust assembly and activation of the NLRP3 inflammasome via producing mitochondrial reactive oxygen species.	Oxygen	178-184	NLR family, pyrin domain containing 3	Mus musculus	122-127
30907806-3	2019	METHODS: The authors present a bioengineered approach to the design of a fat graft based on mathematical theory, which can estimate the limitations of oxygen delivery.	Oxygen	151-157	FAT atypical cadherin 1	Homo sapiens	73-76
30907806-6	2019	Calculations were performed in both spherical and planar geometry to calculate the maximum allowable fat graft size from an oxygen delivery standpoint.	Oxygen	124-130	FAT atypical cadherin 1	Homo sapiens	101-104
30907806-8	2019	Maximum allowable fat graft thickness is only approximately 1 to 2 mm at external oxygen partial pressures of 10 to 40 mm Hg; any thicker and an anoxic or necrotic core likely develops.	Oxygen	82-88	FAT atypical cadherin 1	Homo sapiens	18-21
30878663-11	2019	Overexpression of CLPP inhibited senescence in vitro, by reducing mitochondrial ROS and altering oxygen consumption.	Oxygen	97-103	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Sus scrofa	18-22
33312227-1	2019	We report that TiO2 coatings formed via atomic layer deposition (ALD) may tune the activity of IrO2, RuO2, and FTO for the oxygen-evolution and chlorine-evolution reactions (OER and CER).	Oxygen	123-129	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	111-114
30907806-11	2019	Applying principles of mass transfer theory can predict whether a fat graft has a favorable chance of surviving from an oxygen delivery standpoint and can direct the development of strategies for improved fat graft oxygenation.	Oxygen	120-126	FAT atypical cadherin 1	Homo sapiens	66-69
22548980-1	2012	Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant.	Oxygen	120-126	neuroglobin	Mus musculus	46-57
30371362-10	2019	BT:Co sintered with LiF leads to a quasi-symmetric hysteresis loop, indicating that F- may insert into an oxygen site and counteract the formation of oxygen vacancies.	Oxygen	106-112	LIF interleukin 6 family cytokine	Homo sapiens	20-23
30371362-10	2019	BT:Co sintered with LiF leads to a quasi-symmetric hysteresis loop, indicating that F- may insert into an oxygen site and counteract the formation of oxygen vacancies.	Oxygen	150-156	LIF interleukin 6 family cytokine	Homo sapiens	20-23
31172463-4	2019	The phagocyte oxidase complex employs a heterodimeric transmembrane protein composed of gp91phox and p22phox to relay electrons from NADPH to molecular oxygen, while other cofactors contribute to localization and regulation of the activity of the assembled oxidase.	Oxygen	152-158	cytochrome b-245 alpha chain	Homo sapiens	101-108
22548980-5	2012	Exposure of the immature brains (P0, P7) to acute (8% O(2), 6h) and chronic systemic hypoxia (10% O(2), 7 days) led to differential activation of neuroglobin varying with maturational stage (P0, P7) and severity of hypoxia.	Oxygen	54-58	neuroglobin	Mus musculus	146-157
22548980-5	2012	Exposure of the immature brains (P0, P7) to acute (8% O(2), 6h) and chronic systemic hypoxia (10% O(2), 7 days) led to differential activation of neuroglobin varying with maturational stage (P0, P7) and severity of hypoxia.	Oxygen	98-102	neuroglobin	Mus musculus	146-157
34662695-6	2022	We found that the combination of Tomatis sound therapy with hyperbaric oxygen therapy had a superior effect in improving autism symptoms than each intervention alone (CARS after therapy 35.04 +- 13.38 versus 49.34 +- 17.54 before the intervention, p < 0.001).	Oxygen	71-77	cysteinyl-tRNA synthetase 1	Homo sapiens	167-171
31197773-3	2019	Thus, the capacity to determine oxygen levels or cellular oxygenation status in specific tissue locations is essential to deepen our understanding of HSC biology.	Oxygen	32-38	fucosyltransferase 1 (H blood group)	Homo sapiens	150-153
31528845-3	2019	Here, we demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.	Oxygen	46-48	solute carrier family 25 member 6	Homo sapiens	69-73
31528845-4	2019	Deletion of adipocyte Ant2 improves obesity-induced intracellular adipocyte hypoxia by decreasing obesity-induced adipocyte oxygen demand, without effects on mitochondrial number or mass, or oligomycin-sensitive respiration.	Oxygen	124-130	solute carrier family 25 member 6	Homo sapiens	22-26
34624317-7	2022	After adjusting for gestational age and BPD severity, mortality was found to be associated with the amount of supplemental oxygen required at NICU discharge (aHR: 4.10, p=0.001), presence of a gastrostomy tube (aHR: 8.13, P = .012), and presence of a CSF shunt (aHR: 4.31, p=0.021).	Oxygen	123-129	aryl hydrocarbon receptor	Homo sapiens	158-161
30463908-7	2018	We identified MAPK kinase kinase 8 (MAP3K8) as a target gene of hypoxia-induced factor (HIF), a transcription factor controlled by oxygen tension, upstream of the p38/MAPK pathway.	Oxygen	131-137	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	36-42
30825546-5	2019	When the testis-torsioned rats were given ERbeta agonist during the detorsion period, tubular injury was lessened, sperm count and motility were increased, while the production of reactive oxygen metabolites and apoptosis in the testis tissues were totally suppressed.	Oxygen	189-195	estrogen receptor 2	Rattus norvegicus	42-48
34935052-7	2022	In the present study, miRNA-mediated modulation of ANG and BDNF was explored in an oxygen-induced retinopathy mouse model and human retinal microvascular endothelial cells (HRECs) under hypoxia.	Oxygen	83-89	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	51-54
30885340-8	2019	Finally, IKKbeta inhibition also affects endothelial cell function in a cancer-independent manner, as IKKbeta inhibition reduced pathological retinal angiogenesis in a mouse model of oxygen-induced retinopathy.	Oxygen	183-189	inhibitor of kappaB kinase beta	Mus musculus	9-16
30885340-8	2019	Finally, IKKbeta inhibition also affects endothelial cell function in a cancer-independent manner, as IKKbeta inhibition reduced pathological retinal angiogenesis in a mouse model of oxygen-induced retinopathy.	Oxygen	183-189	inhibitor of kappaB kinase beta	Mus musculus	102-109
30911037-6	2019	In patient fibroblasts, the decrease of EF-Ts was paralleled by up-regulation of EF-Tu and induction of genes involved in mitochondrial biogenesis, along with increased expression of respiratory chain subunits and normal oxygen consumption rate.	Oxygen	221-227	Ts translation elongation factor, mitochondrial	Homo sapiens	40-45
30631432-3	2018	HO-2 is expressed in type I cells, the primary O2-sensing cells of the CB, and binds to O 2 with low affinity.	Oxygen	47-49	heme oxygenase 2	Mus musculus	0-4
34866334-6	2022	In addition, inhibition of NF-kappaB by the small molecule inhibitor Bay-11-7082 led to lower levels of NLRP3 inflammasomes and cleaved caspase-1 proteins in BV2 cells after oxygen-glucose deprivation and reoxygenation.	Oxygen	174-180	caspase 1	Mus musculus	136-145
30129112-0	2018	Long noncoding RNA HOTTIP alleviates oxygen-glucose deprivation-induced neuronal injury via modulating miR-143/hexokinase 2 pathway.	Oxygen	37-43	Hoxa distal transcript antisense RNA	Mus musculus	19-25
30129112-0	2018	Long noncoding RNA HOTTIP alleviates oxygen-glucose deprivation-induced neuronal injury via modulating miR-143/hexokinase 2 pathway.	Oxygen	37-43	microRNA 143	Mus musculus	103-110
30866900-14	2019	Additional sequential lobar lavage and continued GM-CSF therapy as an outpatient resulted in complete resolution of oxygen requirement and return to normal pulmonary physiology.	Oxygen	116-122	colony stimulating factor 2	Homo sapiens	49-55
30129112-0	2018	Long noncoding RNA HOTTIP alleviates oxygen-glucose deprivation-induced neuronal injury via modulating miR-143/hexokinase 2 pathway.	Oxygen	37-43	hexokinase 2	Mus musculus	111-123
34967214-3	2021	The fluoride anions are successfully introduced into the oxygen sublattice, which is confirmed by a combined analysis using XRD, STEM, and TGA techniques.	Oxygen	57-63	T-box transcription factor 1	Homo sapiens	139-142
30022248-7	2018	RESULTS: The partial pressures of oxygen of the Spred2-/- mice after reperfusion were significantly worse than those of WT mice (p &lt; 0.01).	Oxygen	34-40	sprouty-related EVH1 domain containing 2	Mus musculus	48-54
30617181-3	2019	In the canonical HIF signaling pathway, HIF-prolyl hydroxylase 3 (PHD3) suppresses HIF-2alpha protein by post-translational hydroxylation under sufficient oxygen availability.	Oxygen	155-161	endothelial PAS domain protein 1	Homo sapiens	83-93
34508569-9	2021	Validation in the remaining 37 patients indicated that high miR-181c predicted reduced peakV O2 response (multiple linear regression, beta = -2.60, P = 0.011), and LR status (multiple logistic regression, odds ratio = 0.48, P = 0.010), independent of age, sex, body mass index, and resting heart rate.	Oxygen	93-95	microRNA 181c	Homo sapiens	60-68
30801172-5	2019	CoP which was compared as a control sample under the same experimental condition also produced H2O2 through activating dioxygen but did not degrade organic compounds at all.	Oxygen	119-127	caspase recruitment domain family member 16	Homo sapiens	0-3
30801172-6	2019	The electrochemical analysis for the electron transfers on Cu xP and CoP showed that the number of electrons transferred to O2 is 3 and 2, respectively, which explains why OH radical is generated on Cu xP, not on CoP.	Oxygen	124-126	caspase recruitment domain family member 16	Homo sapiens	69-72
30836371-1	2019	Hypoxia-inducible factor 1alpha (HIF1alpha) is a key regulator of oxygen homeostasis, and its target genes mediate adaptive, protective, and pathological processes.	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
30836371-1	2019	Hypoxia-inducible factor 1alpha (HIF1alpha) is a key regulator of oxygen homeostasis, and its target genes mediate adaptive, protective, and pathological processes.	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-42
30642892-2	2019	Here, we show that depletion of ATP generates reactive oxygen species that activate ATM.	Oxygen	55-61	ATM serine/threonine kinase	Homo sapiens	84-87
30428359-4	2018	HO-1 mitigates TB pathophysiology by diminishing myeloid cell-mediated oxidative damage caused by reactive oxygen and/or nitrogen intermediates, which control granulocytic karyorrhexis to generate a zonal HO-1 response.	Oxygen	107-113	heme oxygenase 1	Homo sapiens	0-4
30424786-3	2018	Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair.	Oxygen	85-91	erythropoietin	Mus musculus	114-117
30417859-0	2018	Heat Shock Protein 70 (HSP70) Reduces Hepatic Inflammatory and Oxidative Damage in a Rat Model of Liver Ischemia/Reperfusion Injury with Hyperbaric Oxygen Preconditioning.	Oxygen	148-154	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-21
30417859-0	2018	Heat Shock Protein 70 (HSP70) Reduces Hepatic Inflammatory and Oxidative Damage in a Rat Model of Liver Ischemia/Reperfusion Injury with Hyperbaric Oxygen Preconditioning.	Oxygen	148-154	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-28
34955004-0	2021	Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM).	Oxygen	75-81	sulfiredoxin 1	Homo sapiens	10-24
30053508-11	2019	In addition, HIF-2alpha translation is controlled by iron regulatory protein (IRP) activity, providing another level of interdependence between iron and oxygen homeostasis.	Oxygen	153-159	endothelial PAS domain protein 1	Homo sapiens	13-23
34955004-0	2021	Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM).	Oxygen	75-81	sulfiredoxin 1	Homo sapiens	207-221
30360067-0	2018	L12 Atomic Ordered Substrate Enhanced Pt-Skin Cu3Pt Catalyst for Efficient Oxygen Reduction Reaction.	Oxygen	75-81	ribosomal protein L12	Homo sapiens	0-3
34955004-0	2021	Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM).	Oxygen	75-81	sulfiredoxin 1	Homo sapiens	223-228
30360084-4	2018	The experimental results demonstrate that these bimetallic sites can be partially preserved or reoxidized into Pt-O-Ce with a low coordination number with oxygen under realistic conditions, leading to the appropriate CO adsorption and activating the efficient activity of Pt1/ PN-CeO2 for CO oxidation at low temperature.	Oxygen	155-161	zinc finger protein 77	Homo sapiens	272-275
30686087-9	2019	Overexpression of SCO2 restored the beneficial effect of CR on antagonizing Ang II-induced expression of AAA-related molecules and reactive oxygen species generation in p53-/- vascular smooth muscle cells.	Oxygen	140-146	SCO2 cytochrome c oxidase assembly protein	Mus musculus	18-22
34911756-2	2021	Recently, the mass-independent fractionation of oxygen isotopes (O-MIF) has been used as a tool for estimating pO2 and productivity during the Proterozoic.	Oxygen	48-54	macrophage migration inhibitory factor	Homo sapiens	67-70
29894205-10	2018	In newborn mice, MV with air or 40% O2 inhibited EGFR phosphorylation and suppressed Klf4 protein content in lungs (vs. unventilated controls), yielding increased apoptosis.	Oxygen	36-38	epidermal growth factor receptor	Mus musculus	49-53
30592266-0	2019	Normobaric oxygen inhibits AQP4 and NHE1 expression in experimental focal ischemic stroke.	Oxygen	11-17	aquaporin 4	Rattus norvegicus	27-31
34911756-9	2021	Our model also shows that, contrary to previous assertions, marine productivity cannot be reliably constrained by the O-MIF data because the exchange of molecular oxygen (O2) between the atmosphere and surface ocean is controlled more by air-sea gas transfer rates than by biological productivity.	Oxygen	163-169	macrophage migration inhibitory factor	Homo sapiens	120-123
34911756-9	2021	Our model also shows that, contrary to previous assertions, marine productivity cannot be reliably constrained by the O-MIF data because the exchange of molecular oxygen (O2) between the atmosphere and surface ocean is controlled more by air-sea gas transfer rates than by biological productivity.	Oxygen	171-173	macrophage migration inhibitory factor	Homo sapiens	120-123
34944075-1	2021	Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation.	Oxygen	73-79	cofilin 1	Homo sapiens	22-29
30515398-0	2018	HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.	Oxygen	27-33	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-6
29931197-9	2018	Interestingly, also human fibroblasts from Marfan (FBN1) and LDS (TGFBR2 and SMAD3) patients showed lower oxygen consumption.	Oxygen	106-112	fibrillin 1	Homo sapiens	51-55
34944075-4	2021	The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions.	Oxygen	246-252	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	24-32
30452596-13	2018	In the oxygen-induced retinopathy (OIR) mouse model, Sirt1 ablation markedly suppressed retinal revascularization and consequently increased retinal avascularity.	Oxygen	7-13	sirtuin 1	Mus musculus	53-58
34944075-4	2021	The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions.	Oxygen	246-252	cofilin 1	Homo sapiens	37-41
34910358-11	2022	In vitro studies showed that metformin inhibited Gli1 expression in RAW264.7 macrophages exposed to 90% oxygen, which was reversed after purmorphamine pretreatment.	Oxygen	104-110	GLI-Kruppel family member GLI1	Mus musculus	49-53
30043181-6	2018	Altogether, the results obtained by different groups showed that MAO-A played a key role in the regulation of physiological cardiac function and in the development of acute and chronic heart diseases through two mechanisms: the regulation of substrate concentrations and the intracellular production of reactive oxygen species.	Oxygen	312-318	monoamine oxidase A	Homo sapiens	65-70
34890296-11	2022	Trx activates MKK4-p38MAPK-PGC1alpha pathway leading to rescue of UCP2 and decreased O2 - generation in hyperoxia.	Oxygen	85-87	mitogen-activated protein kinase 14	Mus musculus	19-26
34890296-11	2022	Trx activates MKK4-p38MAPK-PGC1alpha pathway leading to rescue of UCP2 and decreased O2 - generation in hyperoxia.	Oxygen	85-87	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	27-36
34813329-3	2021	Subsequent reaction with O2 yields a side-on eta2 vanadium-superoxo species, 3.	Oxygen	25-27	DNA polymerase iota	Homo sapiens	45-49
34783528-8	2021	In general, the Bi@beta-Sb monolayer may be an excellent trifunctional catalyst that exhibits high activity toward all electrode reactions of hydrogen and oxygen.	Oxygen	155-161	5'-aminolevulinate synthase 2	Homo sapiens	19-26
34482590-9	2021	It was also found that the SNP in the av-UCP gene caused reduced oxygen consumption.	Oxygen	65-71	uncoupling protein 3	Gallus gallus	41-44
34420157-3	2021	In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of alpha5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells.	Oxygen	126-132	laminin, alpha 5	Mus musculus	327-333
34791807-4	2021	Our data illustrates that Carbonic Anhydrases IX and XII (CA IX/XII) are critical for leukaemic cell survival in the O2 -deprived milieu.	Oxygen	117-119	carbonic anhydrase 9	Homo sapiens	58-67
34791807-5	2021	CA IX and XII function as transmembrane proteins that mediate intracellular pH under low O2 conditions.	Oxygen	89-91	carbonic anhydrase 9	Homo sapiens	0-5
34537371-8	2021	Bmp4 (mesoderm) was enhanced by VPA when using ESCs cultured under 20% O2.	Oxygen	71-73	bone morphogenetic protein 4	Homo sapiens	0-4
34838849-9	2021	Tbeta4 ameliorated oxidative damage and suppressed reactive oxygen species production in Abeta-treated SH-SY5Y cells.	Oxygen	60-66	trace amine associated receptor 6	Homo sapiens	0-6
34822898-1	2022	The oxygen based membrane biofilm (O2-MBfR) has been proved to be a novel technology in treating greywater (GW) and response surface methodology (RSM) was used to model the removal of chemical oxygen demand (COD) and total nitrogen (TN) with operation parameters COD/TN ratio, system pH and lumen air pressure (LAP).	Oxygen	4-10	C-type lectin domain family 3 member B	Homo sapiens	233-235
34822898-1	2022	The oxygen based membrane biofilm (O2-MBfR) has been proved to be a novel technology in treating greywater (GW) and response surface methodology (RSM) was used to model the removal of chemical oxygen demand (COD) and total nitrogen (TN) with operation parameters COD/TN ratio, system pH and lumen air pressure (LAP).	Oxygen	4-10	C-type lectin domain family 3 member B	Homo sapiens	267-269
34587543-1	2021	Reactive oxygen species that increase during cardiovascular disease (CVD) react with protein cysteine residues to form a glutathione adduct by S-glutathionylation, which is selectively removed by glutaredoxin-1 (Glrx).	Oxygen	9-15	glutaredoxin	Homo sapiens	196-210
34587543-1	2021	Reactive oxygen species that increase during cardiovascular disease (CVD) react with protein cysteine residues to form a glutathione adduct by S-glutathionylation, which is selectively removed by glutaredoxin-1 (Glrx).	Oxygen	9-15	glutaredoxin	Homo sapiens	212-216
34739186-6	2022	Fibronectin increased NRVMs oxygen consumption rate and ATP content via FAK-ERK1/2-Drp1.	Oxygen	28-34	mitogen activated protein kinase 3	Rattus norvegicus	76-82
34827886-3	2021	The alien species occurrences correlated positively (p < 0.05) with poor water quality, such as rivers with high ammonia-nitrogen and nitrite, but negatively with phosphate and dissolved oxygen.	Oxygen	187-193	COP9 signalosome subunit 2	Homo sapiens	4-9
34719921-3	2021	By performing oxygen-vacancy defect termination for the bulk-channel and back-channel surface of the ultrathin SnO channel, the presented p-channel SnO TFT exhibited good device performances with a reasonable TFT mobility of ~0.47 cm2 V-1 s-1, a high on/off current ratio of ~106, low off current of <10-12 A, and a subthreshold swing of ~2.5 V decade-1, which was improved compared with the conventional p-channel SnO TFTs.	Oxygen	14-20	strawberry notch homolog 1	Homo sapiens	111-114
34719921-3	2021	By performing oxygen-vacancy defect termination for the bulk-channel and back-channel surface of the ultrathin SnO channel, the presented p-channel SnO TFT exhibited good device performances with a reasonable TFT mobility of ~0.47 cm2 V-1 s-1, a high on/off current ratio of ~106, low off current of <10-12 A, and a subthreshold swing of ~2.5 V decade-1, which was improved compared with the conventional p-channel SnO TFTs.	Oxygen	14-20	strawberry notch homolog 1	Homo sapiens	148-151
30585412-7	2019	Pex11a-/- consumed less oxygen, indicating a decrease in fatty acid oxidation, which is consistent with the accumulation of very long- and long-chain fatty acids.	Oxygen	24-30	peroxisomal biogenesis factor 11 alpha	Mus musculus	0-6
34719921-3	2021	By performing oxygen-vacancy defect termination for the bulk-channel and back-channel surface of the ultrathin SnO channel, the presented p-channel SnO TFT exhibited good device performances with a reasonable TFT mobility of ~0.47 cm2 V-1 s-1, a high on/off current ratio of ~106, low off current of <10-12 A, and a subthreshold swing of ~2.5 V decade-1, which was improved compared with the conventional p-channel SnO TFTs.	Oxygen	14-20	strawberry notch homolog 1	Homo sapiens	415-418
34509493-5	2021	In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2.	Oxygen	175-177	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	122-127
30855255-5	2019	The corresponding sodium thiolates, however, break up the Rh2(AcO)4 framework in the presence of O2 to form an oligomeric chain of triply S-bridged Rh(III) ions, each with six Rh-S (2.36 +- 0.02 A) bonds.	Oxygen	97-99	Rh associated glycoprotein	Homo sapiens	58-67
30371279-11	2018	Real-time oxygen consumption rates in isolated mitochondria showed reduced respiratory function in Sigmar1-/- hearts compared with wild-type hearts.	Oxygen	10-16	sigma non-opioid intracellular receptor 1	Mus musculus	99-106
34216036-5	2021	Our results from liquid chromatography mass spectrometry, mitochondrial oxygen consumption rate (OCR), and protein analyses indicate that PRMT8(-/-) knockout mice presented with altered membrane phospholipid composition, decreased mitochondrial stress capacity, and increased neuroinflammatory markers, such as TNF-alpha and ionized calcium binding adaptor molecule 1 (Iba1, a specific marker for microglia/macrophage activation) after hypoxic stress.	Oxygen	72-78	protein arginine N-methyltransferase 8	Mus musculus	138-143
29718366-0	2018	Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma.	Oxygen	30-36	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	113-117
30318520-0	2018	Mutant p53 blocks SESN1/AMPK/PGC-1alpha/UCP2 axis increasing mitochondrial O2-  production in cancer cells.	Oxygen	75-77	sestrin 1	Homo sapiens	18-23
30144413-6	2019	Despite that, Hif1a mRNA expression was significantly increased, clearly indicating that the oxygen-deprived environment introduced a hypoxia response in the cells, we found no hypoxia-induced changes in neither ZO1 abundancy nor in the expression of Zo1 and Zeb1 mRNA.	Oxygen	93-99	hypoxia inducible factor 1, alpha subunit	Mus musculus	14-19
30613928-0	2019	Oxygen consumption rate for evaluation of COQ2 variants associated with multiple system atrophy.	Oxygen	0-6	coenzyme Q2, polyprenyltransferase	Homo sapiens	42-46
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	Oxygen	258-264	complement C2	Homo sapiens	81-84
30051920-3	2018	Using the mouse model of oxygen-induced retinopathy (OIR) which yields defined zones of retinal ischemia, our goal was to investigate the role of Nogo-A in vascular regeneration.	Oxygen	25-31	reticulon 4	Mus musculus	146-152
29992757-9	2018	Lower CC16 in gastric fluid was associated with higher FiO2 at 6 h (P = 0.009), higher PaCO2 at 24 h (P = 0.03), more ventilator days (P = 0.012) and more days with supplemental oxygen (P = 0.03).	Oxygen	178-184	secretoglobin family 1A member 1	Homo sapiens	6-10
29992757-10	2018	Infants who had either died or were still treated with supplemental oxygen at 36 weeks postmenstrual age had lower CC16 in gastric fluid than infants with none of these outcomes (P = 0.049).	Oxygen	68-74	secretoglobin family 1A member 1	Homo sapiens	115-119
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	Oxygen	258-264	complement C2	Homo sapiens	150-153
34833408-5	2021	One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration.	Oxygen	118-124	phenylalanine hydroxylase	Homo sapiens	54-56
31051057-0	2019	Hyperbaric oxygen treatment ameliorates gentamicin-induced nephrotoxicity and expression of kidney injury molecule 1 in the rat model.	Oxygen	11-17	hepatitis A virus cellular receptor 1	Rattus norvegicus	92-116
30241314-6	2018	It is found that the number of Si-bound non-bridging oxygen in the vicinity of Gd3+ considerably increases with growing ionic radius and concentration of network-modifier ions.	Oxygen	53-59	GRDX	Homo sapiens	79-82
34707293-5	2021	Unexpectedly, we observed that glycogen synthesis and degradation are increased in response to catecholamines, and that glycogen turnover is required to produce reactive oxygen species leading to the activation of p38 MAPK, which drives UCP1 expression.	Oxygen	170-176	mitogen-activated protein kinase 14	Mus musculus	214-222
30208516-8	2018	Our data showed that overexpression of irisin in mice with the adenovirus resulted in enhanced mitochondrial respiration with a higher oxygen consumption rate.	Oxygen	135-141	fibronectin type III domain containing 5	Homo sapiens	39-45
30124700-6	2018	Copper-oxide tips (CuOx tips) consist of a bulk copper apex, terminated by a covalently connected single oxygen atom, which chemically passivates the tip.	Oxygen	105-111	TOR signaling pathway regulator	Homo sapiens	13-16
30340204-7	2019	The following DFT calculation fully supported that the detailed coordination mode of Cd2+ and SQ went through six-membered carbonyl oxygen and the CO group in the amide chain.	Oxygen	132-138	CD2 molecule	Homo sapiens	85-88
34707293-5	2021	Unexpectedly, we observed that glycogen synthesis and degradation are increased in response to catecholamines, and that glycogen turnover is required to produce reactive oxygen species leading to the activation of p38 MAPK, which drives UCP1 expression.	Oxygen	170-176	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	237-241
30382305-2	2019	We have demonstrated that pre-treating irradiated immune-deficient mice with hyperbaric oxygen (HBO) prior to UCB CD34+ cell transplantation lowered host systemic erythropoietin (EPO) and improved UCB CD34+ cell homing and engraftment.	Oxygen	88-94	erythropoietin	Mus musculus	163-177
34614473-0	2021	Reactive oxygen species trigger NF-kappaB-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity.	Oxygen	9-15	NLR family pyrin domain containing 3	Bos taurus	51-56
30382305-2	2019	We have demonstrated that pre-treating irradiated immune-deficient mice with hyperbaric oxygen (HBO) prior to UCB CD34+ cell transplantation lowered host systemic erythropoietin (EPO) and improved UCB CD34+ cell homing and engraftment.	Oxygen	88-94	erythropoietin	Mus musculus	179-182
30382305-2	2019	We have demonstrated that pre-treating irradiated immune-deficient mice with hyperbaric oxygen (HBO) prior to UCB CD34+ cell transplantation lowered host systemic erythropoietin (EPO) and improved UCB CD34+ cell homing and engraftment.	Oxygen	88-94	CD34 antigen	Mus musculus	201-205
30216369-8	2018	It has been shown that PKM2 expression is regulated by HIF-1alpha and that PKM2 favors HIF-1alpha transactivation under mild (1% O2) but not severe (0.1% O2) hypoxic conditions, and some of our findings are consistent with these previous results.	Oxygen	129-131	pyruvate kinase M1/2	Homo sapiens	75-79
34651436-0	2021	Structural and Chemical Compatibilities of Li1- x Ni0.5 Co0.2 Mn0.3 O2 Cathode Material with Garnet-Type Solid Electrolyte for All-Solid-State Batteries.	Oxygen	68-70	transglutaminase 1	Homo sapiens	43-46
30200633-0	2018	The Coupling Effect of O2 and H2S on the Corrosion of G20 Steel in a Simulating Environment of Flue Gas Injection in the Xinjiang Oil Field.	Oxygen	23-25	chromosome 3 open reading frame 18	Homo sapiens	54-57
30200633-4	2018	The effect of environments including the O2-containing environment, the H2S-containing environment, and the O2-H2S-coexisting environment on the corrosion of G20 steel in gas phase and liquid phase was discussed.	Oxygen	41-43	chromosome 3 open reading frame 18	Homo sapiens	158-161
30650258-2	2019	The concentration of Pd2+ is the key factor for the density of Pd nanoparticles (Pd NPs) embedded in the carbon shells, which plays a role in the oxygen reduction reaction (ORR) and surface-enhanced Raman scattering (SERS) properties.	Oxygen	146-152	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	21-24
30200633-4	2018	The effect of environments including the O2-containing environment, the H2S-containing environment, and the O2-H2S-coexisting environment on the corrosion of G20 steel in gas phase and liquid phase was discussed.	Oxygen	108-110	chromosome 3 open reading frame 18	Homo sapiens	158-161
34677913-4	2021	The Ca4.67 Li0.33 (PO4 )3 (OH)-modified Li(Ni0.8 Co0.15 Al0.05 )O2 electrode provides ultra-long term cycling stability, enabling 1000 cycles retaining 66.3% of its initial capacity.	Oxygen	64-66	carbonic anhydrase 4	Homo sapiens	4-7
30200633-5	2018	The results show that the corrosion rate of G20 steel in the O2-H2S-coexisting environment is much higher than the sum of corrosion rates of the O2-containing environment and the H2S-containing environment, regardless of the gas phase and the liquid phase.	Oxygen	61-63	chromosome 3 open reading frame 18	Homo sapiens	44-47
30200633-5	2018	The results show that the corrosion rate of G20 steel in the O2-H2S-coexisting environment is much higher than the sum of corrosion rates of the O2-containing environment and the H2S-containing environment, regardless of the gas phase and the liquid phase.	Oxygen	145-147	chromosome 3 open reading frame 18	Homo sapiens	44-47
34677913-5	2021	Also, morphological degradations such as micro-cracking or amorphization of surface are significantly suppressed by the presence of Ca4.67 Li0.33 (PO4 )3 (OH) layer on the Li(Ni0.8 Co0.15 Al0.05 )O2 , of which the Ca4.67 Li0.33 (PO4 )3 (OH) is transformed to CaF2 via Ca4.67 Li0.33 (PO4 )3 F during the long term cycles reacting with HF in electrolyte.	Oxygen	196-198	carbonic anhydrase 4	Homo sapiens	132-135
30233593-0	2018	Oxygen Saturation on Admission Is a Predictive Biomarker for PD-L1 Expression on Circulating Monocytes and Impaired Immune Response in Patients With Sepsis.	Oxygen	0-6	CD274 molecule	Homo sapiens	61-66
29908837-8	2018	In conclusion, our findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions.	Oxygen	350-356	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	45-51
30838088-2	2019	H2S is synthesized endogenously and mainly metabolized by a mitochondrial sulfide-oxidizing pathway including sulfide:quinone oxidoreductase (SQR), whereby H2S-derived electrons are injected into the respiratory chain stimulating O2 consumption and ATP synthesis.	Oxygen	230-232	crystallin zeta	Homo sapiens	118-140
30634998-14	2019	Interestingly, the Oxygen Consumption Rates (OCR) was increased in M(LPS + IFNgamma) microglia but reduced in M(IL-4) microglia by STF31 treatment.	Oxygen	19-25	interleukin 4	Mus musculus	112-116
30530987-0	2019	At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2alpha.	Oxygen	21-27	hepcidin antimicrobial peptide	Homo sapiens	46-54
34677913-5	2021	Also, morphological degradations such as micro-cracking or amorphization of surface are significantly suppressed by the presence of Ca4.67 Li0.33 (PO4 )3 (OH) layer on the Li(Ni0.8 Co0.15 Al0.05 )O2 , of which the Ca4.67 Li0.33 (PO4 )3 (OH) is transformed to CaF2 via Ca4.67 Li0.33 (PO4 )3 F during the long term cycles reacting with HF in electrolyte.	Oxygen	196-198	carbonic anhydrase 4	Homo sapiens	214-217
30530987-3	2019	In this issue of the JCI, Schwartz and colleagues show that duodenal HIF-2alpha is itself regulated by hepcidin, thereby indicating that this transcription factor is not only regulated by oxygen, but also by iron.	Oxygen	188-194	endothelial PAS domain protein 1	Homo sapiens	69-79
30530987-3	2019	In this issue of the JCI, Schwartz and colleagues show that duodenal HIF-2alpha is itself regulated by hepcidin, thereby indicating that this transcription factor is not only regulated by oxygen, but also by iron.	Oxygen	188-194	hepcidin antimicrobial peptide	Homo sapiens	103-111
34677913-5	2021	Also, morphological degradations such as micro-cracking or amorphization of surface are significantly suppressed by the presence of Ca4.67 Li0.33 (PO4 )3 (OH) layer on the Li(Ni0.8 Co0.15 Al0.05 )O2 , of which the Ca4.67 Li0.33 (PO4 )3 (OH) is transformed to CaF2 via Ca4.67 Li0.33 (PO4 )3 F during the long term cycles reacting with HF in electrolyte.	Oxygen	196-198	CCR4-NOT transcription complex subunit 8	Homo sapiens	259-263
29913563-5	2018	In extracellular flux analyses with glucose, the basal, ATP-linked, and maximum oxygen consumption rates (OCRs) were decreased in Hint2-/- hepatocytes and in HepG2 cells lacking HINT-2.	Oxygen	80-86	histidine triad nucleotide binding protein 2	Homo sapiens	130-135
34677913-5	2021	Also, morphological degradations such as micro-cracking or amorphization of surface are significantly suppressed by the presence of Ca4.67 Li0.33 (PO4 )3 (OH) layer on the Li(Ni0.8 Co0.15 Al0.05 )O2 , of which the Ca4.67 Li0.33 (PO4 )3 (OH) is transformed to CaF2 via Ca4.67 Li0.33 (PO4 )3 F during the long term cycles reacting with HF in electrolyte.	Oxygen	196-198	carbonic anhydrase 4	Homo sapiens	268-271
30463689-7	2019	Akt2 deletion triggered insulin resistance, compromised cardiac contractile and intracellular Ca2+ property, mitochondrial ultrastructural damage, elevated O2- production, as well as suppressed autophagy and mitophagy, accompanied with elevated levels of NLRP3 and iNOS, the effects of which were significantly attenuated or ablated by diallyl sulfide.	Oxygen	156-158	thymoma viral proto-oncogene 2	Mus musculus	0-4
34699701-7	2021	Results: A/L, Tr/L, Tr/To, and L/To DXA indexes were significantly different between CS and O1 as well as between non-CS women O2 compared to O1 and C. These indexes had a highly significant correlation among each other and also in relation to their BMI (p < 0.0001).	Oxygen	127-129	citrate synthase	Homo sapiens	118-120
30098988-3	2018	METHODS AND RESULTS: In vitro experiments revealed that PAR-1 enhanced Dox-induced mitochondrial dysfunction, reactive oxygen species and cell death of cardiac myocytes and cardiac fibroblasts.	Oxygen	119-125	coagulation factor II (thrombin) receptor	Mus musculus	56-61
31486323-0	2019	C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1alpha through the Oxygen-Dependent Degradation Pathway.	Oxygen	97-103	heat shock protein 90 alpha family class A member 1	Homo sapiens	11-16
34721664-8	2021	Hip and knee joint stiffness are reported to increase with velocity, and a lower ankle and higher knee joint stiffness are linked to a lower oxygen cost of running; however, no relationship with performance has yet been investigated.	Oxygen	141-147	hedgehog interacting protein	Homo sapiens	0-3
31486323-12	2019	Surprisingly, we found that when the C-terminal of HSP90 is inhibited, HIF-1alpha degradation occurs through the proteasome and prolyl hydroxylases in an oxygen-dependent manner even in very low levels of oxygen (tumor hypoxia levels).	Oxygen	154-160	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
31486323-12	2019	Surprisingly, we found that when the C-terminal of HSP90 is inhibited, HIF-1alpha degradation occurs through the proteasome and prolyl hydroxylases in an oxygen-dependent manner even in very low levels of oxygen (tumor hypoxia levels).	Oxygen	205-211	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
30159399-2	2018	The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids.	Oxygen	75-81	heparan sulfate proteoglycan 2	Homo sapiens	35-38
34535574-8	2021	Tsc1-deficient mTECs exhibited overproduction of reactive oxygen species and malfunction of lysosome, with lysosome membrane permeabilization and the release of cathepsin B and cathepsin L to the cytosol, which then lead to Bid cleaved into active truncated Bid and subsequently intrinsic apoptosis.	Oxygen	58-64	TSC complex subunit 1	Mus musculus	0-4
30356966-0	2018	Fe-CoP Electrocatalyst Derived from a Bimetallic Prussian Blue Analogue for Large-Current-Density Oxygen Evolution and Overall Water Splitting.	Oxygen	98-104	caspase recruitment domain family member 16	Homo sapiens	3-6
30356966-3	2018	The Fe-CoP/NF (nickel foam) catalyst shows efficient electrocatalytic activity for oxygen evolution reaction, requiring low overpotentials of 190, 295, and 428 mV to achieve 10, 500, and 1000 mA cm-2 current densities in 1.0 m KOH solution.	Oxygen	83-89	caspase recruitment domain family member 16	Homo sapiens	7-10
30301563-0	2019	Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.	Oxygen	11-17	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	44-50
30285278-12	2019	We found that leptin enhanced carotid sinus nerve activity at baseline and in response to 10% O2 in vivo.	Oxygen	94-96	leptin	Mus musculus	14-20
34535574-8	2021	Tsc1-deficient mTECs exhibited overproduction of reactive oxygen species and malfunction of lysosome, with lysosome membrane permeabilization and the release of cathepsin B and cathepsin L to the cytosol, which then lead to Bid cleaved into active truncated Bid and subsequently intrinsic apoptosis.	Oxygen	58-64	BH3 interacting domain death agonist	Mus musculus	224-227
31382832-0	2019	Hyperbaric oxygen promotes mitophagy by activating CaMKKbeta/AMPK signal pathway in rats of neuropathic pain.	Oxygen	11-17	calcium/calmodulin-dependent protein kinase kinase 2	Rattus norvegicus	51-60
29673995-3	2018	The contribution of involved Cd2+ removal mechanism varied with feedstock due to the different components and oxygen-containing functional groups.	Oxygen	110-116	CD2 molecule	Sus scrofa	29-32
34680580-11	2021	GJA1 expression in HL-1 cells incubated with exosomes from OSAS patients with AF was lower than that with exosomes from patients without AF after controlling for age and sex and was negatively correlated with the AHI and oxygen desaturation index (ODI), especially during the non-rapid eye movement period (NREM) of OSAS patients with AF (all p < 0.05).	Oxygen	221-227	gap junction protein alpha 1	Homo sapiens	0-4
30069023-4	2018	Using a elegant co-culture cellular system, we were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by Interleukine-6 (IL-6), Activin-A and Granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation.	Oxygen	85-91	colony stimulating factor 3	Homo sapiens	258-295
30069023-4	2018	Using a elegant co-culture cellular system, we were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by Interleukine-6 (IL-6), Activin-A and Granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation.	Oxygen	85-91	colony stimulating factor 3	Homo sapiens	297-302
31815118-2	2019	Key transcription factors that recognize xenobiotics or xenobiotic-induced stress such as reactive oxygen species (ROS), include AhR, PXR, CAR, MTF, Nrf2, NF-kappaB, and AP-1.	Oxygen	99-105	CXADR pseudogene 1	Homo sapiens	139-142
30461218-1	2019	OBJECTIVE: Determine whether higher targeted oxygen levels are associated with reduced incidence of pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) in extremely premature infants.	Oxygen	45-51	PVR cell adhesion molecule	Homo sapiens	172-175
34634897-5	2021	Forty-seven ILD patients performed a six minute walk test (6MWT) on room air (RA) and with oxygen supplementation (Ox).	Oxygen	91-97	hypocretin neuropeptide precursor	Homo sapiens	115-117
30461218-11	2019	CONCLUSION: Higher targeted oxygen saturation was associated with reduced risk of PH or elevated PVR in extremely preterm infants compared to lower oxygen saturation target.	Oxygen	28-34	PVR cell adhesion molecule	Homo sapiens	97-100
30712667-1	2019	INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1).	Oxygen	52-58	serpin family E member 1	Homo sapiens	199-207
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	serpin family E member 1	Homo sapiens	64-72
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	serpin family E member 1	Homo sapiens	126-134
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	endoglin	Homo sapiens	187-195
30712667-6	2019	RESULTS: Culture in low oxygen (1%) increased angiogenic VEGFA, SERPINE1 and placental growth factor (PGF) mRNA and VEGFA and SERPINE1 protein levels, and reduced anti-angiogenic ANGPT1, endoglin (ENG) and soluble fms-like tyrosine kinase-e15a (sFlt-e15a) mRNA (all P = 0.0001).	Oxygen	24-30	endoglin	Homo sapiens	197-200
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Oxygen	164-170	caspase recruitment domain family member 16	Homo sapiens	47-50
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Oxygen	164-170	caspase recruitment domain family member 16	Homo sapiens	91-94
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Oxygen	198-204	caspase recruitment domain family member 16	Homo sapiens	47-50
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Oxygen	198-204	caspase recruitment domain family member 16	Homo sapiens	91-94
29882235-5	2018	It is demonstrated that this biomimetic core-shell nanoplatform with oxygen generation can be partial to accumulate in tumor and downregulate the expression of hypoxia-inducible factor 1alpha, which can further enhance the therapeutic effects of chemotherapy and reduce the expression of programmed death ligand 1 (PD-L1).	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	160-191
30640062-2	2019	We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hydroxymethylcytosine (5hmC).	Oxygen	61-67	tet methylcytosine dioxygenase 1	Homo sapiens	227-237
34634897-6	2021	The 6MWT distance (6MWD) was significantly greater with oxygen supplementation (RA: 242+-143 m vs Ox: 345+-106 m p<0,01).	Oxygen	56-62	hypocretin neuropeptide precursor	Homo sapiens	98-100
30640062-2	2019	We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hydroxymethylcytosine (5hmC).	Oxygen	152-154	tet methylcytosine dioxygenase 1	Homo sapiens	227-237
30640062-6	2019	Transient ectopic expression of KDM4C or TET1 in ambient atmospheric oxygen achieved the same.	Oxygen	69-75	tet methylcytosine dioxygenase 1	Homo sapiens	41-45
29917232-7	2018	Taken together, these findings demonstrate a key role for the PHD2-HIF-2alpha couple in Type I cells with respect to the oxygen sensing functions of the carotid body.	Oxygen	121-127	endothelial PAS domain protein 1	Homo sapiens	67-77
34622409-3	2021	The change in pH level affects the chemical oxygen demand (COD)/biochemical oxygen demand (BOD) ratio and when it is less than 0.63, chemical treatments are more effective over the biological treatment methods such as upflow anaerobic sludge blankets (UASB).	Oxygen	44-50	phenylalanine hydroxylase	Homo sapiens	14-16
29917232-16	2018	These findings implicate specific components of the HIF hydroxylase pathway (PHD2 and HIF-2alpha) within Type I cells of the carotid body with respect to the oxygen sensing and adaptive functions of that organ.	Oxygen	158-164	endothelial PAS domain protein 1	Homo sapiens	86-96
29394491-9	2018	Cit does not alter the oxygen cost of moderate-intensity walking in young or older adults, but Cit improved the rate of rise in oxygen uptake at exercise onset in men.	Oxygen	128-134	citron rho-interacting serine/threonine kinase	Homo sapiens	95-98
29653079-3	2018	Carboxyatractyloside titration of O2 consumption rate (Jo) at clamped [ADP] of 21 muM gave ANT abundance of 0.97 +- 0.14 nmol ANT/mg and a flux control coefficient of 82% +- 6%.	Oxygen	34-36	solute carrier family 25 member 6	Homo sapiens	91-94
30398300-0	2018	Confined Pt1 1+ Water Clusters in a MOF Catalyze the Low-Temperature Water-Gas Shift Reaction with both CO2 Oxygen Atoms Coming from Water.	Oxygen	108-114	zinc finger protein 77	Homo sapiens	9-12
30444368-1	2018	A core-shell ensemble of bovine hemoglobin (Hb) and human serum albumin (HSA) is an artificial O2 carrier as a red blood cell substitute.	Oxygen	95-97	albumin	Bos taurus	58-71
34622409-3	2021	The change in pH level affects the chemical oxygen demand (COD)/biochemical oxygen demand (BOD) ratio and when it is less than 0.63, chemical treatments are more effective over the biological treatment methods such as upflow anaerobic sludge blankets (UASB).	Oxygen	76-82	phenylalanine hydroxylase	Homo sapiens	14-16
30545041-8	2018	Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls.	Oxygen	102-108	sirtuin 3	Mus musculus	26-31
29653079-3	2018	Carboxyatractyloside titration of O2 consumption rate (Jo) at clamped [ADP] of 21 muM gave ANT abundance of 0.97 +- 0.14 nmol ANT/mg and a flux control coefficient of 82% +- 6%.	Oxygen	34-36	solute carrier family 25 member 6	Homo sapiens	126-129
34331901-9	2021	When normothermic H9c2 cells were transfected with TRPV1 siRNA we observed reduced pDrp1S616 and MFF abundance, elongated mitochondria, and reduced rates of mitochondrial-associated oxygen consumption, mimicking the effects of hypothermic culture.	Oxygen	182-188	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
29475132-7	2018	Mechanistically, the inhibitory action of butyrate on the Nlrp3 inflammasome was attributed to a blockade of lipid raft redox signaling platforms to produce O2 - upon 7-Ket or CHC stimulations.	Oxygen	157-159	NLR family, pyrin domain containing 3	Mus musculus	58-63
30619855-4	2018	Similarly, oxygen-dependent changes in lung development are attenuated in transgenic Sftpc EC-SOD mice that over-express EC-SOD in pulmonary alveolar epithelial type II cells.	Oxygen	11-17	superoxide dismutase 3, extracellular	Mus musculus	91-97
34551158-9	2021	More importantly, forced overexpression of oxygen stable form of HIF1alpha completely reversed attenuated pro-inflammatory and glycolytic gene expression in BHLHE40-deficient macrophages.	Oxygen	43-49	basic helix-loop-helix family member e40	Homo sapiens	157-164
30619855-13	2018	These findings demonstrate pulmonary expression of EC-SOD preserves short-term memory in adult female mice exposed to neonatal hyperoxia, thus suggesting anti-oxidants designed to alleviate oxygen-induced lung disease such as in preterm infants may also be neuroprotective.	Oxygen	190-196	superoxide dismutase 3, extracellular	Mus musculus	51-57
30448061-10	2018	In contrast, Notch ligand Delta-like 4 (Dll4) and Notch1 intracellular domain (N1-ICD) expression were inhibited in the regressing capillaries of central retina but comparable in the angiogenic plexus after high oxygen treatment.	Oxygen	212-218	notch 1	Mus musculus	50-56
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	Oxygen	107-113	toll like receptor 4	Homo sapiens	45-49
34399087-0	2021	Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells.	Oxygen	161-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	176-204
29741363-4	2018	In this new catalytic system, oxygen-vacancy-rich NiO provides abundant active sites for dissociation of water, and the negatively charged P species in NiP2 facilitate adsorption of hydrogen intermediates.	Oxygen	30-36	BCL2 interacting protein 2	Homo sapiens	152-156
30372875-6	2018	Increased expression of caveolin-1 and tight junction protein ZO-1 were found in rats with hyperbaric oxygen exposure compared to those in IS group.	Oxygen	102-108	tight junction protein 1	Rattus norvegicus	39-66
30372875-7	2018	CONCLUSIONS: Hyperbaric oxygen exposure improved the permeability of the blood-brain barrier in rats with global cerebral ischemia/reperfusion injury, and increased expression of caveolin-1 and tight junction protein ZO-1 were involved in the mechanisms.	Oxygen	24-30	tight junction protein 1	Rattus norvegicus	194-221
34638996-6	2021	Our results indicated compound 5104434 selectively restored HDAC1 enzymatic activity after oxygen and glucose deprivation, preserved neurite morphology, and protected neurons from ischemic damage in vitro.	Oxygen	91-97	histone deacetylase 1	Rattus norvegicus	60-65
30353303-4	2018	In a genome-wide time-to-event analysis of the primary outcome of death or hospitalization in 331 subjects, 97 single nucleotide polymorphisms (SNPs) showed evidence of interaction with oxygen therapy at P < 1e-5, including 7 SNPs near arylsulfatase B (ARSB; P = 6e-6).	Oxygen	186-192	arylsulfatase B	Homo sapiens	236-251
30353303-4	2018	In a genome-wide time-to-event analysis of the primary outcome of death or hospitalization in 331 subjects, 97 single nucleotide polymorphisms (SNPs) showed evidence of interaction with oxygen therapy at P < 1e-5, including 7 SNPs near arylsulfatase B (ARSB; P = 6e-6).	Oxygen	186-192	arylsulfatase B	Homo sapiens	253-257
30353303-5	2018	In microarray expression profiling on 51 whole blood samples from 37 individuals, at screening and/or at 12-month follow-up, ARSB expression was associated with the primary outcome depending on oxygen treatment.	Oxygen	194-200	arylsulfatase B	Homo sapiens	125-129
30353303-9	2018	The effect of long-term oxygen therapy in COPD varied based on ARSB expression and genotype.	Oxygen	24-30	arylsulfatase B	Homo sapiens	63-67
34563261-10	2021	CONCLUSIONS: These data suggest that LCN2-mediated reactive oxygen species affects expression of MHC class I molecules in BMDCs, leading to lower levels of CD8+ effector T-cell proliferation during mycobacterial infection.	Oxygen	60-66	lipocalin 2	Mus musculus	37-41
30534005-11	2018	Oxygen evolving complex and PSII complex proteins (PsbH, PsbS, PsbR and Psb28) were found to be abundant in the most damaged leaf zone.	Oxygen	0-6	psbH	Solanum lycopersicum	51-55
34520495-1	2021	OBJECTIVES: Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis.	Oxygen	21-27	xanthine dehydrogenase	Homo sapiens	49-72
30359022-3	2018	The key intermediate is assumed to be one, where both the aldehyde (via oxygen) and the eta1 allyl group are coordinated to the metal center, and C-C bond formation between the terminal allylic carbon and carbonyl carbon is the rate-determining step.	Oxygen	72-78	secreted phosphoprotein 1	Homo sapiens	88-92
30555336-6	2018	In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues following MSC treatment.	Oxygen	72-78	musculin	Homo sapiens	137-140
34520495-1	2021	OBJECTIVES: Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis.	Oxygen	21-27	xanthine dehydrogenase	Homo sapiens	74-77
29588180-4	2018	The concept of oxygen tolerance first recognized in the study of glutathione peroxidase was further advanced and refined by those studying [NiFeSe]-hydrogenases, selenosubtilisin, and thioredoxin reductase.	Oxygen	15-21	peroxiredoxin 5	Homo sapiens	184-205
34577609-7	2021	Importantly, we find that inhibition of TRPA1 prevents loss of CAPs during oxygen and glucose deprivation (OGD) and improves the recovery.	Oxygen	75-81	Ca2+-dependent secretion activator	Mus musculus	63-67
30281301-5	2018	Nitrite and Cys-SNO produced higher amounts of N-NA in the presence of oxygen, whereas NAC-SNO was almost oxygen insensitive.	Oxygen	106-112	synuclein alpha	Homo sapiens	87-90
34343565-4	2021	Eukaryotic acetate-dependent acetyl CoA synthetase 2 (Acss2) is predominantly cytosolic, but is also found in the nucleus following oxygen or glucose deprivation, or upon acetate exposure.	Oxygen	132-138	acyl-CoA synthetase short chain family member 2	Homo sapiens	54-59
34543127-8	2021	Moreover, HMGB1 inhibition rescued NO production and eliminated O2 - production in experimental NEC mice through eNOS activation.	Oxygen	64-68	high mobility group box 1	Mus musculus	10-15
30237172-8	2018	H2S reacted specifically with a ferric verdoheme intermediate of HO, and verdoheme cleavage proceeded through an O2-independent hydrolysis-like mechanism.	Oxygen	113-115	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	0-3
30237172-10	2018	We propose that H2S could largely affect O2 sensing by mammalian HO, which is supposed to relay hypoxic signals by decreasing CO output to regulate cellular functions.	Oxygen	41-43	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	16-19
34501217-2	2021	Therefore, the study aimed to assess the influence of nocturnal oxygen saturation parameters on the onset of DM2 among OSA patients.	Oxygen	64-70	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	109-112
30207456-3	2018	Electron energy loss spectroscopy and X-ray photoelectron spectroscopy with different etching depths further prove the formation of LiF and F- doping on the LNCM surface, which simultaneously triggers partial Ni3+ reduction to Ni2+; and the metal-oxygen bond is partially replaced by a higher energy metal-fluorine bond.	Oxygen	247-253	LIF interleukin 6 family cytokine	Homo sapiens	132-135
34501217-6	2021	Cox regression models were used to assess the effect of oxygen saturation parameters on the onset of DM2.	Oxygen	56-62	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	101-104
34501217-8	2021	One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI, AHI, decreased basal O2 and O2 nadir value, while lowered mean O2 desaturation has not shown statistical significance.	Oxygen	107-109	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	53-56
34501217-8	2021	One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI, AHI, decreased basal O2 and O2 nadir value, while lowered mean O2 desaturation has not shown statistical significance.	Oxygen	114-116	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	53-56
34501217-8	2021	One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI, AHI, decreased basal O2 and O2 nadir value, while lowered mean O2 desaturation has not shown statistical significance.	Oxygen	149-151	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	53-56
29772916-0	2018	Home Oxygen Therapy for Bronchiolitis: An Evaluation of the Primary Care Providers" Experience at Sea Level.	Oxygen	5-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
34501217-10	2021	Therefore, basal O2 is independent from AHI, BMI and age is a risk factor of DM2 among OSA patients.	Oxygen	17-19	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	77-80
29772916-2	2018	Our objective was to understand experience with home oxygen at sea level and determine potential barriers and benefits of its use.	Oxygen	53-59	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
34440934-10	2021	An upregulation of ALP and OC occurred during osteogenesis in BMP2 containing media under 20% O2; BMP2 free osteogenic media downregulated ALP and also led to higher sGAG release.	Oxygen	94-96	bone morphogenetic protein 2	Homo sapiens	98-102
30205103-11	2018	Moreover, streptocyclinone B (2) was able to inhibit the activity of beta-secretase 1 and decrease the release of reactive oxygen species in BV2 cells stimulated with Abeta.	Oxygen	123-129	amyloid beta (A4) precursor protein	Mus musculus	167-172
34407931-5	2021	Despite coupling between the two reactions being required for the correct Alkbh5 functioning, the mechanisms linking dioxygen activation to m6A binding are not fully understood.	Oxygen	117-125	alkB homolog 5, RNA demethylase	Homo sapiens	74-80
29246449-7	2018	In this review we discuss who low fat mass and the resulting relative deficiencies in leptin and adiponectin could contribute to the increase frequency of oxygen desaturations that occurs days after birth in the smallest and youngest premature infants.	Oxygen	155-161	leptin	Homo sapiens	86-92
30323763-2	2018	Previous work in our lab has demonstrated that depression induced by chronic stress could generate brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals disorder, accompanied by the impairment of hippocampal neuronal plasticity, decrease of brain-derived neurotrophic factor, and reduction of the number and complexity of adult neurons in the dentate gyrus.	Oxygen	111-117	brain derived neurotrophic factor	Mus musculus	282-315
34407931-7	2021	We show that binding of m6A to Alkbh5 induces a metal-centered rearrangement of alphaKG that increases the exposed area of the metal, making it available for binding O2 Our study reveals the molecular mechanisms underlying activation of Alkbh5, therefore opening new perspectives for the design of novel strategies to control gene expression and cancer progression.	Oxygen	166-168	alkB homolog 5, RNA demethylase	Homo sapiens	31-37
34408077-3	2021	Because oxidative stress and mitochondrial dysfunctions are implicated in FRDA, we demonstrated the systemic delivery of catalysts activity of gold cluster superstructures (Au8-pXs) to improve cell response to mitochondrial reactive oxygen species and thereby alleviate FRDA-related pathology in mesenchymal stem cells from patients with FRDA.	Oxygen	233-239	frataxin	Homo sapiens	74-78
30405877-8	2018	Upregulation of MMP1 and downregulation of COL1A1 along with increased DNA damage were also observed under 21% O2 vs 5% O2.	Oxygen	111-113	matrix metallopeptidase 1	Homo sapiens	16-20
34159698-4	2021	Based on detailed studies, it is found that the catalytic reaction process well follows the classic MVK mechanism, and adsorption/activation of O 2 into active oxygen species (O*) should be the rate-determining step for CH 4 conversion.	Oxygen	144-147	mevalonate kinase	Homo sapiens	100-103
30405877-8	2018	Upregulation of MMP1 and downregulation of COL1A1 along with increased DNA damage were also observed under 21% O2 vs 5% O2.	Oxygen	120-122	matrix metallopeptidase 1	Homo sapiens	16-20
34159698-4	2021	Based on detailed studies, it is found that the catalytic reaction process well follows the classic MVK mechanism, and adsorption/activation of O 2 into active oxygen species (O*) should be the rate-determining step for CH 4 conversion.	Oxygen	160-166	mevalonate kinase	Homo sapiens	100-103
30137082-13	2018	Finally, we observed that AFT1-1UP inhibits oxygen consumption through activation of the RNA-binding protein Cth2.	Oxygen	44-50	Tis11p	Saccharomyces cerevisiae S288C	109-113
30170731-6	2018	Exosomes from obese mice impaired myocyte mitochondrial activity, but blocking with miR-194 sponge attenuated the exosomal miR-194-induced reduction of ATP production (p &lt; 0.05), basal oxygen consumption (p &lt; 0.01) and mitochondrial complex I activity (p &lt; 0.001).	Oxygen	188-194	microRNA 194-1	Mus musculus	84-91
30170731-6	2018	Exosomes from obese mice impaired myocyte mitochondrial activity, but blocking with miR-194 sponge attenuated the exosomal miR-194-induced reduction of ATP production (p &lt; 0.05), basal oxygen consumption (p &lt; 0.01) and mitochondrial complex I activity (p &lt; 0.001).	Oxygen	188-194	microRNA 194-1	Mus musculus	123-130
34445509-2	2021	Mechanisms for the protective effects of the antioxidant enzyme peroxiredoxin-6 (Prx-6) on hippocampal cells during oxygen-glucose deprivation/reoxygenation (OGD/R) were investigated.	Oxygen	116-122	peroxiredoxin 6	Homo sapiens	64-79
30200633-9	2018	Therefore, it can be considered that the coupling effect of O2 and H2S on corrosion of G20 steel in flue gas injection environment is caused by the formation of elemental sulfur in corrosion products.	Oxygen	60-62	chromosome 3 open reading frame 18	Homo sapiens	87-90
34445509-2	2021	Mechanisms for the protective effects of the antioxidant enzyme peroxiredoxin-6 (Prx-6) on hippocampal cells during oxygen-glucose deprivation/reoxygenation (OGD/R) were investigated.	Oxygen	116-122	peroxiredoxin 6	Homo sapiens	81-86
30229580-5	2018	RESULTS: Lack of S1P induced by sphingosine kinase inhibitor (SphKi) treatment caused beta-cell dysfunction and apoptosis, with repression of mitochondrial function shown by decreases in cellular adenosine triphosphate content, the oxygen consumption rate, the expression of oxidative phosphorylation complexes, the mitochondrial membrane potential, and the expression of key regulators of mitochondrial dynamics (mitochondrial dynamin-like GTPase [OPA1] and mitofusin 1 [MFN1]).	Oxygen	232-238	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
29683321-0	2018	Probing Molecular-Scale Catalytic Interactions between Oxygen and Cobalt Phthalocyanine Using Tip-Enhanced Raman Spectroscopy.	Oxygen	55-61	TOR signaling pathway regulator	Homo sapiens	94-97
34439520-3	2021	Specifically, many studies, including our own, have shown that the triggering event of CS-induced renal injury is mitochondrial reactive oxygen species (mROS).	Oxygen	137-143	citrate synthase	Rattus norvegicus	87-89
29683321-1	2018	Ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) is used to investigate adsorption of molecular oxygen (O2) on cobalt(II) phthalocyanine (CoPc) supported on Ag(111) single crystal surfaces, which is the initial step for the oxygen reduction reaction (ORR) using metal Pc catalysts.	Oxygen	107-113	TOR signaling pathway regulator	Homo sapiens	17-20
29683321-1	2018	Ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) is used to investigate adsorption of molecular oxygen (O2) on cobalt(II) phthalocyanine (CoPc) supported on Ag(111) single crystal surfaces, which is the initial step for the oxygen reduction reaction (ORR) using metal Pc catalysts.	Oxygen	115-117	TOR signaling pathway regulator	Homo sapiens	17-20
29601782-3	2018	The transcription factor, hypoxia inducible factor-1alpha (HIF-1alpha), and its regulator, prolylhydroxylase 2 (PHD2), play pivotal roles in the response to oxygen flux by regulating downstream gene expression levels in the liver.	Oxygen	157-163	hypoxia inducible factor 1, alpha subunit	Mus musculus	26-57
29601782-3	2018	The transcription factor, hypoxia inducible factor-1alpha (HIF-1alpha), and its regulator, prolylhydroxylase 2 (PHD2), play pivotal roles in the response to oxygen flux by regulating downstream gene expression levels in the liver.	Oxygen	157-163	hypoxia inducible factor 1, alpha subunit	Mus musculus	59-69
34443008-5	2021	With the aid of XPS, AFM, and surface wetting measurements, we confirmed that a higher surface electron affinity is responsible for the lower specific contact resistance of the oxygen-terminated nanocrystalline diamond films.	Oxygen	177-183	afamin	Homo sapiens	21-24
30015875-6	2018	Secondly, the stable overexpression of Bcl-2 and ability to shift metabolism towards oxidative phosphorylation (OXPHOS) in SKOV3/DDP cells were associated with increased oxygen consumption.	Oxygen	170-176	translocase of inner mitochondrial membrane 8A	Homo sapiens	129-132
34161154-5	2021	Exposure of rats to chronic hypoxia (10% O2, 3 weeks) caused CHPH and selectively increased the expression of Cl--accumulating NKCC1 and reduced the Cl--extruding KCC4.	Oxygen	41-43	solute carrier family 12 member 2	Rattus norvegicus	127-132
30165864-9	2018	Furthermore, inhaled GM-CSF therapy showed a higher response rate, more improvements on PaO2 and P(A-a)O2 than subcutaneous GM-CSF treatment in aPAP patients, suggesting inhaled GM-CSF therapy could have more benefits on aPAP patients.	Oxygen	90-92	colony stimulating factor 2	Homo sapiens	21-27
34161154-5	2021	Exposure of rats to chronic hypoxia (10% O2, 3 weeks) caused CHPH and selectively increased the expression of Cl--accumulating NKCC1 and reduced the Cl--extruding KCC4.	Oxygen	41-43	solute carrier family 12 member 7	Rattus norvegicus	163-167
34330933-5	2021	SIRT5 expression was increased in murine PTECs after IRI in vivo and in human PTECs (hPTECs) exposed to an oxygen/nutrient deprivation (OND) model of IRI in vitro.	Oxygen	107-113	sirtuin 5	Mus musculus	0-5
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Oxygen	216-222	heme oxygenase 1	Homo sapiens	28-32
34251174-7	2021	This species has a unique geometry involving a large displacement of surface Sn, forcing it to attain the coordination resembling that of Sn2+ in SnO, which seems necessary to stabilize O2- and activate metal-oxide surfaces for gas sensing.	Oxygen	186-188	strawberry notch homolog 1	Homo sapiens	146-149
29803741-0	2018	Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.	Oxygen	92-98	ribosomal protein L41	Mus musculus	13-18
34337261-3	2021	We show that the structural deviation from C 3-symmetry increases with the non-bonded interactions between the occupied spx orbitals of the crowns" oxygen atoms and the unoccupied 2s orbital of the cation.	Oxygen	148-154	spexin hormone	Homo sapiens	120-123
30062333-2	2018	In this study, to understand the thermal behavior of the material, molecular dynamics was utilized to investigate the molecular structure, dynamic property, and mechanical behavior of NASH gel subjected to temperature elevation from 300 K to 1500 K. The aluminosilicate skeleton in NASH gel provides plenty of oxygen sites to accept H-bond from the invading water molecules.	Oxygen	310-316	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	184-188
30062333-2	2018	In this study, to understand the thermal behavior of the material, molecular dynamics was utilized to investigate the molecular structure, dynamic property, and mechanical behavior of NASH gel subjected to temperature elevation from 300 K to 1500 K. The aluminosilicate skeleton in NASH gel provides plenty of oxygen sites to accept H-bond from the invading water molecules.	Oxygen	310-316	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	282-286
34191490-2	2021	Because of their intrinsically high reactivity, however, isolation of Cux(O2 -) species is challenging.	Oxygen	74-78	cut like homeobox 1	Homo sapiens	70-73
30131718-11	2018	Identification of unmethylated CpG sites in the CYP19A1 promoter region suggests that granulosa cells were not completely transformed into luteal cells under the present low oxygen in vitro condition.	Oxygen	174-180	aromatase	Bos taurus	48-55
30028452-3	2018	Benefiting from the strong coupling and synergistic effect between CoP QDs and highly conductive S,N-codoped carbon, well-structured porosity and high specific surface area, the resulting CoP@SNC exhibits excellent activities for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and oxygen reduction reaction (ORR), making it a trifunctional electro-catalyst for overall water splitting and rechargeable Zn-air batteries.	Oxygen	230-236	caspase recruitment domain family member 16	Homo sapiens	188-191
30028452-3	2018	Benefiting from the strong coupling and synergistic effect between CoP QDs and highly conductive S,N-codoped carbon, well-structured porosity and high specific surface area, the resulting CoP@SNC exhibits excellent activities for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and oxygen reduction reaction (ORR), making it a trifunctional electro-catalyst for overall water splitting and rechargeable Zn-air batteries.	Oxygen	302-308	caspase recruitment domain family member 16	Homo sapiens	188-191
34295263-2	2021	The fat loss effect of exercise has been intuitively thought to result from increased fat burning during and after exercise, defined by conversion of fatty acid into carbon dioxide in consumption of oxygen.	Oxygen	199-205	FAT atypical cadherin 1	Homo sapiens	4-7
30076663-0	2018	ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast.	Oxygen	36-42	integrin subunit alpha 1	Homo sapiens	0-5
29627643-8	2018	CCl4 was also degraded efficiently by ARs when oxygen in the reaction solution was completely consumed by ARs.	Oxygen	47-53	C-C motif chemokine ligand 4	Homo sapiens	0-4
34295263-2	2021	The fat loss effect of exercise has been intuitively thought to result from increased fat burning during and after exercise, defined by conversion of fatty acid into carbon dioxide in consumption of oxygen.	Oxygen	199-205	FAT atypical cadherin 1	Homo sapiens	86-89
34226665-8	2022	In oxygen-glucose deprivation-treated cultured cortical neurons, Pyk2 inhibition significantly alleviated NMDA receptor-mediated excitotoxicity; similar results were also observed in neonatal HI brain injury.	Oxygen	3-9	PTK2 protein tyrosine kinase 2 beta	Mus musculus	65-69
28975674-2	2018	When it is integrated to FTO/p-CuBi2 O4 (FTO=fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2 .	Oxygen	157-159	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-28
28975674-2	2018	When it is integrated to FTO/p-CuBi2 O4 (FTO=fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2 .	Oxygen	157-159	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	41-44
34209205-4	2021	For example, mutations in genes encoding key players of oxygen-sensing pathway and regulation of EPO production (HIF-EPO pathway), namely VHL, EGLN, EPAS1 and EPO, are well known causative factors that contribute to the development of erythrocytosis.	Oxygen	56-62	von Hippel-Lindau tumor suppressor	Homo sapiens	138-141
28975674-2	2018	When it is integrated to FTO/p-CuBi2 O4 (FTO=fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2 .	Oxygen	258-260	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-28
28975674-2	2018	When it is integrated to FTO/p-CuBi2 O4 (FTO=fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2 .	Oxygen	258-260	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	41-44
34204592-9	2021	Treatment with TAT-NDUFS8 not only significantly improved the assembly of complex I in an NDUFS8-deficient cell line, but also partially rescued complex I functions both in the in-gel activity assay and the oxygen consumption assay.	Oxygen	207-213	tyrosine aminotransferase	Homo sapiens	15-18
30140364-10	2018	Mechanistically, stimulated membrane raft redox signaling platform formation and increased O2 - production by PA to activate NLRP3 inflammasomes in HSCs was blocked by FTZ treatment.	Oxygen	91-93	NLR family, pyrin domain containing 3	Mus musculus	125-130
34117122-1	2021	: Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map.	Oxygen	41-47	hypocretin neuropeptide precursor	Homo sapiens	31-33
34151067-2	2021	Compared with pure CeO2, CuO belts were synthesized using the same method and the corresponding Ce0.5O2:50%Cu2+ bulk materials were synthesized without filter paper as scaffolds; the synthesized Ce1-x O2:x%Cu2+ nanobelts, especially Ce0.5O2:50%Cu2+ nanobelts, can decrease the reaction temperature of CO to CO2 at 100  C with the conversion rate of 100%, much lower than the formerly reported kinds of Ce1-x O2:x%Cu2+ catalysts.	Oxygen	201-203	carboxylesterase 1	Homo sapiens	195-198
29911998-1	2018	Although it has been reported that hypoxia inducible factor 2 alpha (Hif2a), a major transcriptional factor inducible by low oxygen tension, is expressed in the mouse uterus during embryo implantation, its role in pregnancy outcomes remains unclear.	Oxygen	125-131	endothelial PAS domain protein 1	Mus musculus	35-67
29911998-1	2018	Although it has been reported that hypoxia inducible factor 2 alpha (Hif2a), a major transcriptional factor inducible by low oxygen tension, is expressed in the mouse uterus during embryo implantation, its role in pregnancy outcomes remains unclear.	Oxygen	125-131	endothelial PAS domain protein 1	Mus musculus	69-74
34151067-2	2021	Compared with pure CeO2, CuO belts were synthesized using the same method and the corresponding Ce0.5O2:50%Cu2+ bulk materials were synthesized without filter paper as scaffolds; the synthesized Ce1-x O2:x%Cu2+ nanobelts, especially Ce0.5O2:50%Cu2+ nanobelts, can decrease the reaction temperature of CO to CO2 at 100  C with the conversion rate of 100%, much lower than the formerly reported kinds of Ce1-x O2:x%Cu2+ catalysts.	Oxygen	201-203	carboxylesterase 1	Homo sapiens	402-405
34151067-2	2021	Compared with pure CeO2, CuO belts were synthesized using the same method and the corresponding Ce0.5O2:50%Cu2+ bulk materials were synthesized without filter paper as scaffolds; the synthesized Ce1-x O2:x%Cu2+ nanobelts, especially Ce0.5O2:50%Cu2+ nanobelts, can decrease the reaction temperature of CO to CO2 at 100  C with the conversion rate of 100%, much lower than the formerly reported kinds of Ce1-x O2:x%Cu2+ catalysts.	Oxygen	408-410	carboxylesterase 1	Homo sapiens	195-198
34151067-2	2021	Compared with pure CeO2, CuO belts were synthesized using the same method and the corresponding Ce0.5O2:50%Cu2+ bulk materials were synthesized without filter paper as scaffolds; the synthesized Ce1-x O2:x%Cu2+ nanobelts, especially Ce0.5O2:50%Cu2+ nanobelts, can decrease the reaction temperature of CO to CO2 at 100  C with the conversion rate of 100%, much lower than the formerly reported kinds of Ce1-x O2:x%Cu2+ catalysts.	Oxygen	408-410	carboxylesterase 1	Homo sapiens	402-405
34151067-3	2021	Meanwhile, the synthesized Ce1-x O2:x%Cu2+ nanobelts also display better photocatalytic activity for organic dyes.	Oxygen	33-35	carboxylesterase 1	Homo sapiens	27-30
34151067-4	2021	All of these results provide useful information for the potential applications of the synthesized Ce1-x O2:x%Cu2+ nanobelts in catalyst fields.	Oxygen	104-106	carboxylesterase 1	Homo sapiens	98-101
34179639-3	2021	Complexes 1-3 were further structurally confirmed by single-crystal X-ray crystallography, and they displayed dimeric structures in which strontium atoms were connected by alkoxide oxygen atoms of the mu2 type.	Oxygen	181-187	adaptor related protein complex 1 subunit mu 2	Homo sapiens	201-204
29519816-5	2018	Extensive MD simulations with and without the AI helix revealed that backbone carbonyl oxygens at the point of contact between the AI helix and loop L2 can entrap the Lys122 side chain, effectively competing with the substrate, CTP.	Oxygen	87-94	solute carrier family 25 member 1	Homo sapiens	228-231
29611237-1	2018	An efficient metal-free catalyst is presented for oxygen evolution and reduction based on oxidized laser-induced graphene (LIG-O).	Oxygen	50-56	ubiquitin conjugating enzyme E2 K	Homo sapiens	123-126
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	24-26	ubiquitin conjugating enzyme E2 K	Homo sapiens	17-20
34179639-5	2021	In complexes 5-7, trimeric structures were obtained with strontium atoms connected by mu3-O bonds of alkoxide oxygen atoms and mu2-O bonds of alkoxide and beta-diketonate oxygen atoms.	Oxygen	171-177	adaptor related protein complex 1 subunit mu 2	Homo sapiens	127-130
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	24-26	ubiquitin conjugating enzyme E2 K	Homo sapiens	42-45
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	78-84	ubiquitin conjugating enzyme E2 K	Homo sapiens	17-20
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	78-84	ubiquitin conjugating enzyme E2 K	Homo sapiens	42-45
34140895-3	2021	The purpose of this study was to determine if normobaric oxygen (NBO) might effectively induce HSP32 while concurrently inhibiting MEK1/2 and to observe any protective effects on spinal cord injury in DCS rats.	Oxygen	57-63	mitogen activated protein kinase kinase 1	Rattus norvegicus	131-137
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	235-241	ubiquitin conjugating enzyme E2 K	Homo sapiens	17-20
29611237-2	2018	The oxidation of LIG by O2 plasma to form LIG-O boosts its performance in the oxygen evolution reaction (OER), exhibiting a low onset potential of 260 mV with a low Tafel slope of 49 mV dec-1 , as well as an increased activity for the oxygen reduction reaction.	Oxygen	235-241	ubiquitin conjugating enzyme E2 K	Homo sapiens	42-45
34073032-0	2021	Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts.	Oxygen	109-115	C-X-C motif chemokine receptor 3	Homo sapiens	78-83
29741264-6	2018	Secondary CE can also result from defects in the components of the oxygen-sensing pathway (PHD2, HIF2alpha and VHL).	Oxygen	67-73	endothelial PAS domain protein 1	Homo sapiens	97-106
34168844-3	2021	Here, we find that the electrocatalytic activity of single-site MOFs toward the oxygen reduction reaction (ORR) can be tuned by using carbon nanomaterials, i.e., carbon nanotubes and graphene, as supports through MOF-support interactions in the manner of geometric and electronic effects.	Oxygen	80-86	lysine acetyltransferase 8	Homo sapiens	213-216
29531097-6	2018	In NRK-52E cells subjected to oxygen-glucose deprivation, siRNA-mediated knockdown of Gpr97 further increased the expression of survivin and phosphorylated STAT3 and reduced toll-like receptor 4 expression.	Oxygen	30-36	adhesion G protein-coupled receptor G3	Rattus norvegicus	86-91
34163661-7	2021	Probe LW-OTf could be used to detect O2 - or O2 - and ONOO- in lysosomes stimulated by 2-methoxyestradiol (2-ME) or 2-ME and SIN-1 respectively.	Oxygen	37-39	mitogen-activated protein kinase associated protein 1	Mus musculus	125-130
29443459-0	2018	Tunable Bifunctional Activity of Mnx Co3-x O4 Nanocrystals Decorated on Carbon Nanotubes for Oxygen Electrocatalysis.	Oxygen	93-99	keratin 86	Homo sapiens	33-36
29443459-3	2018	Herein, the comprehensive development of manganese cobalt oxide/nitrogen-doped multiwalled carbon nanotube hybrids (Mnx Co3-x O4 @NCNTs) is reported for highly reversible oxygen reduction and evolution reactions (ORR and OER, respectively).	Oxygen	171-177	keratin 86	Homo sapiens	116-119
29443459-5	2018	Electrochemical tests reveal distinctly different oxygen catalytic activities among the hybrids, Mnx Co3-x O4 @NCNTs.	Oxygen	50-56	keratin 86	Homo sapiens	97-100
34163661-7	2021	Probe LW-OTf could be used to detect O2 - or O2 - and ONOO- in lysosomes stimulated by 2-methoxyestradiol (2-ME) or 2-ME and SIN-1 respectively.	Oxygen	45-47	mitogen-activated protein kinase associated protein 1	Mus musculus	125-130
34092769-1	2021	First Aid Oxygen Inhalation and Hyperbaric Oxygen Therapy).	Oxygen	10-16	activation induced cytidine deaminase	Homo sapiens	6-9
29671738-3	2018	We show here that there is an absolute developmental requirement for HIF-2alpha, one of the HIF isoforms, for growth and survival of oxygen sensitive glomus cells of the carotid body.	Oxygen	133-139	endothelial PAS domain protein 1	Homo sapiens	69-79
34092769-6	2021	In contrast, early first aid normobaric oxygen inhalation highly improved or stabilized clinical conditions of DCI.	Oxygen	40-46	activation induced cytidine deaminase	Homo sapiens	25-28
29620105-1	2018	Ceria doped with Sm and Gd (SDC and GDC) has been suggested as a promising candidate for the electrolyte used in solid oxide fuel cells (SOFCs), since it has relatively high oxygen ion conductivity at intermediate temperature.	Oxygen	174-180	solute carrier family 25 member 16	Homo sapiens	36-39
35248853-2	2022	However, traditional TN detection methods have to experience a tedious oxygen digestion process, which tremendously limits the detection speed of TN.	Oxygen	71-77	C-type lectin domain family 3 member B	Homo sapiens	21-23
29620105-6	2018	In this paper, using both first-principle density-functional theory and classical molecular dynamics calculations, we investigate the structural and vibrational properties of the optimized SDC and GDC structures, such as bonding analysis, phonon density-of-state and mean-square-displacement of the oxygen ions.	Oxygen	299-305	solute carrier family 25 member 16	Homo sapiens	197-200
29620105-7	2018	Also, we report the direction-dependent vibrations at the specific frequency of the oxygen ions near the vacancies, activation energies, and diffusion coefficients of SDC and GDC which can extend our understanding of diffusion dynamics in doped ceria-based electrolytes for SOFC applications.	Oxygen	84-90	solute carrier family 25 member 16	Homo sapiens	175-178
31458646-2	2018	By varying the reduction time (10 min, 1 h, and 15 h), oxygen functional groups on rGO were tremendously controlled and they were named RG1, RG2, and RG3, respectively.	Oxygen	55-61	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	136-139
29636521-3	2018	The comparison of PR1 and PR2 pocket properties showed that bound PR2 pockets were more hydrophobic with more oxygen atoms and fewer nitrogen atoms than PR1 pockets.	Oxygen	110-116	transmembrane protein 37	Homo sapiens	18-21
35248853-2	2022	However, traditional TN detection methods have to experience a tedious oxygen digestion process, which tremendously limits the detection speed of TN.	Oxygen	71-77	C-type lectin domain family 3 member B	Homo sapiens	146-148
29614836-1	2018	Voltage-gated potassium (Kv) channels, including Kv3.1 and Kv3.4, are known as oxygen sensors, and their function in hypoxia has been well investigated.	Oxygen	79-85	potassium voltage-gated channel subfamily C member 4	Homo sapiens	59-64
35248853-4	2022	The transformations of nitrogenous substances during the oxidative digestion process are observed by using ultraviolet (UV) spectroscopy and the concentration of TN can be predicted by only using the variation of spectrum in the early oxygen digestion process.	Oxygen	235-241	C-type lectin domain family 3 member B	Homo sapiens	162-164
35607379-7	2022	The results showed that PHB was upregulated in HRCECs, while PHB knockdown promoted the generation of reactive oxygen species from mitochondria via inhibition of the activation of complex I. Additionally, the apoptosis rate of HRCECs in the HG group was notably enhanced compared with that in the NG group.	Oxygen	111-117	prohibitin 1	Homo sapiens	61-64
28759496-6	2018	Our primary outcome was end-tidal oxygen (ETO2) after 3-minute preoxygenation.	Oxygen	34-40	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	42-46
35413642-10	2022	One common feature in both cardiomyocytes and tumor cells was that Mfn2 increased the ratio of oxygen consumption rate to extracellular acidification rate, suggesting Mfn2 triggered a shift from aerobic glycolysis to mitochondrial oxidative metabolism.	Oxygen	95-101	mitofusin 2	Mus musculus	67-71
29438880-2	2018	Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2.	Oxygen	90-96	hydroxyacid oxidase 1, liver	Mus musculus	8-23
29438880-2	2018	Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2.	Oxygen	90-96	hydroxyacid oxidase 1, liver	Mus musculus	25-28
35413642-10	2022	One common feature in both cardiomyocytes and tumor cells was that Mfn2 increased the ratio of oxygen consumption rate to extracellular acidification rate, suggesting Mfn2 triggered a shift from aerobic glycolysis to mitochondrial oxidative metabolism.	Oxygen	95-101	mitofusin 2	Mus musculus	167-171
29438880-2	2018	Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2.	Oxygen	156-162	hydroxyacid oxidase 1, liver	Mus musculus	8-23
29438880-2	2018	Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2.	Oxygen	156-162	hydroxyacid oxidase 1, liver	Mus musculus	25-28
35623248-3	2022	SnS2 QDs and singlet oxygen (1(O2)2*) produced from the system as light-emitting devices jointly enhance the ECL response and significantly improve the sensitivity of the ECL immunosensor.	Oxygen	31-33	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
29438880-3	2018	Such liposome-GOx after intravenous injection with effective tumor retention is able to exhaust glucose and oxygen within the tumor, producing cytotoxic H2O2 and enhancing hypoxia, as vividly visualized by non-invasive in vivo photoacoustic imaging.	Oxygen	108-114	hydroxyacid oxidase 1, liver	Mus musculus	14-17
29473308-5	2018	For the hydrogen and oxygen evolution reactions with the Fe-CoP HTPAs in alkaline medium, the low overpotentials of 98 and 230 mV are observed, respectively, and the required cell voltage toward overall water splitting is only as low as 1.59 V for the driving current density of 10 mA cm-2 .	Oxygen	21-27	caspase recruitment domain family member 16	Homo sapiens	60-63
35623248-4	2022	Dissolved oxygen and SnS2 QDs respectively generate HOO  and SnS2 QDs - under negative potential, and react with transient SO4 - to emit strong light respectively, so as to jointly enhance the ECL response.	Oxygen	10-16	sodium voltage-gated channel alpha subunit 11	Homo sapiens	61-65
35579458-11	2022	Together, these results suggested that reduction of oxygen concentration and OMZ expansion may increase the use of nitrate by SAR11 and N2 production in the BoB.	Oxygen	52-58	G protein-coupled receptor 15	Homo sapiens	157-160
29362227-7	2018	Mitochondria in RCAN1-depleted cardiomyocytes have reduced membrane potential, O2 consumption, and generation of reactive oxygen species, as well as a reduced capacity for mitochondrial Ca2+ uptake.	Oxygen	79-81	regulator of calcineurin 1	Homo sapiens	16-21
29678953-5	2018	In one such population, the Sherpas, lower muscle PPARA expression is associated with a decreased capacity for fatty acid oxidation, potentially improving the efficiency of oxygen utilisation.	Oxygen	173-179	peroxisome proliferator activated receptor alpha	Homo sapiens	50-55
35579458-13	2022	We demonstrate the prokaryotic community and its potential functions in nitrogen metabolism in the Bay of Bengal (BoB), where oxygen concentration is barely above suboxic level.	Oxygen	126-132	G protein-coupled receptor 15	Homo sapiens	114-117
29619425-1	2018	Background: Heme oxygenase-1 (HO-1) is a protein secreted by immune cells as a part of immune response mechanism.HO-1 can be induced by variety agents that causingoxidative stress, such as exposure to 100% oxygenat2,4 ATA pressure.It plays a vital role in maintaining cellular homeostasis.This study was conducted to identify the effect of hyperbaric oxygen exposure in cultured ofPBMCthat infected by HIV-1.	Oxygen	17-23	heme oxygenase 1	Homo sapiens	30-34
29619425-1	2018	Background: Heme oxygenase-1 (HO-1) is a protein secreted by immune cells as a part of immune response mechanism.HO-1 can be induced by variety agents that causingoxidative stress, such as exposure to 100% oxygenat2,4 ATA pressure.It plays a vital role in maintaining cellular homeostasis.This study was conducted to identify the effect of hyperbaric oxygen exposure in cultured ofPBMCthat infected by HIV-1.	Oxygen	17-23	heme oxygenase 1	Homo sapiens	113-117
35634326-7	2022	Hypoxia (5% oxygen) increased the expression of EGFR, CXCR4, CTGF, and HIF-1alpha, the number and differentiation in fibrocytes.	Oxygen	12-18	cellular communication network factor 2	Homo sapiens	61-65
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	catenin beta 1	Homo sapiens	256-268
35465672-0	2022	Morphology-Dependent Electrocatalytic Performance of a Two-Dimensional Nickel-Iron MOF for Oxygen Evolution Reaction.	Oxygen	91-97	lysine acetyltransferase 8	Homo sapiens	83-86
29394491-0	2018	Impact of l-citrulline supplementation on oxygen uptake kinetics during walking.	Oxygen	42-48	citron rho-interacting serine/threonine kinase	Homo sapiens	10-22
29394491-1	2018	Supplementation with l-citrulline (Cit) has been shown to improve muscle oxygenation and oxygen uptake kinetics during moderate- to high-intensity cycling in young men.	Oxygen	73-79	citron rho-interacting serine/threonine kinase	Homo sapiens	21-33
29394491-1	2018	Supplementation with l-citrulline (Cit) has been shown to improve muscle oxygenation and oxygen uptake kinetics during moderate- to high-intensity cycling in young men.	Oxygen	73-79	citron rho-interacting serine/threonine kinase	Homo sapiens	35-38
29394491-2	2018	The aim of this study was to test the hypothesis that Cit would improve oxygen uptake kinetics during walking in older and young adults.	Oxygen	72-78	citron rho-interacting serine/threonine kinase	Homo sapiens	54-57
29339137-6	2018	Similarly, exposure of in vitro produced bovine embryos to atmospheric oxygen concentrations was associated with disruptions in the transcriptional regulation of TET1, TET3, and DNMT3a, along with the DNA methyltransferase co-factor HELLS.	Oxygen	71-77	tet methylcytosine dioxygenase 1	Bos taurus	162-166
29339137-6	2018	Similarly, exposure of in vitro produced bovine embryos to atmospheric oxygen concentrations was associated with disruptions in the transcriptional regulation of TET1, TET3, and DNMT3a, along with the DNA methyltransferase co-factor HELLS.	Oxygen	71-77	tet oncogene family member 3	Bos taurus	168-172
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	embryonic ectoderm development	Mus musculus	153-156
29479593-3	2018	The relative stabilities of six surface oxygen vacancies from Ov1 to Ov6 on the In2O3(110) surface were compared.	Oxygen	40-46	protein tyrosine phosphatase 4A2	Homo sapiens	62-65
29118013-7	2018	Diminishing glycolytic flux by knockdown of the first and final enzyme of glycolysis, i.e., hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption.	Oxygen	198-204	pyruvate kinase M1/2	Homo sapiens	134-137
29240923-16	2018	JIA neutrophils express higher levels of MMP8 and FCGR1B, which may be implicated in disease pathology through the release of proteases and reactive oxygen metabolites, causing systemic inflammation and damage to joints.	Oxygen	149-155	matrix metallopeptidase 8	Homo sapiens	41-45
29240923-16	2018	JIA neutrophils express higher levels of MMP8 and FCGR1B, which may be implicated in disease pathology through the release of proteases and reactive oxygen metabolites, causing systemic inflammation and damage to joints.	Oxygen	149-155	Fc gamma receptor Ib, pseudogene	Homo sapiens	50-56
35500221-7	2022	Interestingly, inhibition of NAMPT in healthy monocytes completely abrogated the IFNgamma-induced oxygen consumption, comparable to levels observed in CGD monocytes.	Oxygen	98-104	nicotinamide phosphoribosyltransferase	Homo sapiens	29-34
29377664-5	2018	We further demonstrate that the same behavior occurs when oxygen interacts with p-type polymer TQ1 films, indicating it is possible to be a universal effect for organic semiconductors.	Oxygen	58-64	selectin L	Homo sapiens	95-98
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	NLR family, pyrin domain containing 3	Mus musculus	274-279
35120400-7	2022	The hydrogel formulation exhibits a robust and validated visible red-orange-green "traffic light" spectrum in response to oxygen changes, regardless of swelling state, pH, or autofluorescence from skin, thereby enabling clinician friendly naked-eye feedback.	Oxygen	122-128	phenylalanine hydroxylase	Homo sapiens	168-170
29159826-2	2018	These disorders are caused by mutations in the gene encoding hemoglobin-beta (HBB), a vital protein found in red blood cells (RBCs) that carries oxygen from lungs to all parts of the human body.	Oxygen	145-151	hemoglobin subunit beta	Homo sapiens	61-76
29159826-2	2018	These disorders are caused by mutations in the gene encoding hemoglobin-beta (HBB), a vital protein found in red blood cells (RBCs) that carries oxygen from lungs to all parts of the human body.	Oxygen	145-151	hemoglobin subunit beta	Homo sapiens	78-81
29434038-0	2018	Poldip2 is an oxygen-sensitive protein that controls PDH and alphaKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.	Oxygen	14-20	DNA polymerase delta interacting protein 2	Homo sapiens	0-7
29130578-8	2018	Notably, mitochondrially targeted p53 (mito-p53) directly reduced mitochondria DNA-encoded ND2 and ND4 gene expression resulting in increased reactive oxygen species (ROS) and reduced mitochondrial oxygen consumption.	Oxygen	151-157	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	99-102
35209722-0	2022	Simultaneous Temperature and Pressure Measurements in Compressible Flow Using Nanosecond O2 CARS.	Oxygen	89-91	cysteinyl-tRNA synthetase 1	Homo sapiens	92-96
28830269-10	2018	Our data suggest that perfusion culture of MSC into allogenic bone substitute with HEMOXCell  as a natural oxygen carrier is promising for tissue engineering applications to oxygenate hypoxic areas and to promote cellular proliferation.	Oxygen	107-113	musculin	Homo sapiens	43-46
29459227-9	2018	It remains to be studied whether the peroxide-STAT3-hepcidin axis simply acts to continuously compensate for oxygen fluctuations or is directly involved in iron sensing per se.	Oxygen	109-115	hepcidin antimicrobial peptide	Homo sapiens	52-60
35209722-1	2022	Simultaneous pure-rotational (PRCARS) and vibrational (VCARS) O2 CARS spectroscopy was performed at elevated pressure and lowered temperature conditions in non-reacting compressible flow.	Oxygen	62-64	cysteinyl-tRNA synthetase 1	Homo sapiens	65-69
29687108-7	2018	The as-fabricated SERS substrate could also be efficiently recycled using O2 plasma for the detection of other biomolecules.	Oxygen	74-76	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	18-22
35209722-2	2022	We applied dual-pump CARS in a three-laser three-color configuration to simultaneously acquire the PRCARS and VCARS spectra of O2.	Oxygen	127-129	cysteinyl-tRNA synthetase 1	Homo sapiens	21-25
35228125-6	2022	XOR, which catalyzes the terminal two steps of purine degradation, is the major source of both reactive oxygen species (O2.-, H2O2) and UA.	Oxygen	120-122	xanthine dehydrogenase	Homo sapiens	0-3
29580991-10	2018	Our results suggest a new role of FTH1 as a co-regulator for the FIH-mediated oxygen sensing pathway.	Oxygen	78-84	ferritin heavy chain 1	Homo sapiens	34-38
29198026-9	2018	The chemisorbed oxygen (Obeta) and the lattice oxygen (Oalpha) which took part in the removal reaction largely existed in CuMn/HBC.	Oxygen	16-22	keratin 88, pseudogene	Homo sapiens	127-130
29198026-9	2018	The chemisorbed oxygen (Obeta) and the lattice oxygen (Oalpha) which took part in the removal reaction largely existed in CuMn/HBC.	Oxygen	47-53	keratin 88, pseudogene	Homo sapiens	127-130
35477503-4	2022	METHODS: In this study, we developed oncolytic herpes simplex virus type 1 expressing HMGB1 protein (HSV-HMGB1) and investigated the cytotoxic effect of HSV-HMGB1 and its parental virus (HSV-ble) on three colorectal cancer cells (HCT116, SW480, and HT29) under normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	299-305	high mobility group box 1	Homo sapiens	86-91
29068435-2	2018	Hypoxia-inducible factor-1alpha (HIF-1alpha) has a critical role in cellular oxygen homeostasis.	Oxygen	77-83	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
29068435-2	2018	Hypoxia-inducible factor-1alpha (HIF-1alpha) has a critical role in cellular oxygen homeostasis.	Oxygen	77-83	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
29309143-2	2018	Here, we demonstrate that installation of a noncanonical Ndelta-methyl histidine (NMH) as the proximal heme ligand in the oxygen binding protein myoglobin (Mb) leads to substantial increases in heme redox potential and promiscuous peroxidase activity.	Oxygen	122-128	myoglobin	Homo sapiens	145-154
29309143-2	2018	Here, we demonstrate that installation of a noncanonical Ndelta-methyl histidine (NMH) as the proximal heme ligand in the oxygen binding protein myoglobin (Mb) leads to substantial increases in heme redox potential and promiscuous peroxidase activity.	Oxygen	122-128	myoglobin	Homo sapiens	156-158
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	peroxisome proliferator activated receptor alpha	Homo sapiens	16-59
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	peroxisome proliferator activated receptor alpha	Homo sapiens	61-66
29514048-4	2018	Exposure of HUVEC and VVEC to 1% O2 for 4-24 h triggered rather moderate activation of ATP breakdown into adenosine via the CD39-CD73 axis.	Oxygen	33-35	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	124-128
29295858-5	2018	A generalized down-regulation of HIF-1alpha and its downstream targets was detected in parallel with reactive gliosis, suggesting high oxygen levels during retinal degeneration.	Oxygen	135-141	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
35477503-4	2022	METHODS: In this study, we developed oncolytic herpes simplex virus type 1 expressing HMGB1 protein (HSV-HMGB1) and investigated the cytotoxic effect of HSV-HMGB1 and its parental virus (HSV-ble) on three colorectal cancer cells (HCT116, SW480, and HT29) under normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	299-305	high mobility group box 1	Homo sapiens	105-110
35181309-2	2022	A few recent studies have reported that manganese superoxide dismutase (MnSOD) can effectively modulate EMT phenotype by influencing cellular redox environment via altering the intracellular ratio between O2- and H2O2.	Oxygen	205-208	superoxide dismutase 2	Homo sapiens	40-70
29763367-0	2018	HSP70 protects rats and hippocampal neurons from central nervous system oxygen toxicity by suppression of NO production and NF-kappaB activation.	Oxygen	72-78	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-5
29763367-2	2018	The aim of this study is to understand the effects and the underlying mechanism of heat shock protein 70 on central nervous system oxygen toxicity and its mechanisms in vivo and in vitro.	Oxygen	131-137	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	83-104
29763367-5	2018	Seizure latency and first electrical discharge were recorded to evaluate the effects of HSP70 on central nervous system oxygen toxicity.	Oxygen	120-126	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	88-93
29623135-1	2018	Background: To clarify the efficiency of mask O2 and high-flow O2 (HFO) treatments following cardiopulmonary bypass (CPB) in obese patients.	Oxygen	46-48	ankyrin repeat and KH domain containing 1	Homo sapiens	41-45
35181309-2	2022	A few recent studies have reported that manganese superoxide dismutase (MnSOD) can effectively modulate EMT phenotype by influencing cellular redox environment via altering the intracellular ratio between O2- and H2O2.	Oxygen	205-208	superoxide dismutase 2	Homo sapiens	72-77
29763367-12	2018	In the in vitro study, heat shock protein 70-overexpression decreased the nitric oxide, nitric oxide synthase, and inducible nitric oxide synthase levels as well as the cytoplasm/nucleus ratio of nuclear factor-kappaB and protected neurons from hyperbaric oxygen-induced cell injury.	Oxygen	256-262	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-44
29763367-13	2018	In conclusion, overexpression of heat shock protein 70 in hippocampal neurons may protect rats from central nervous system oxygen toxicity by suppression of neuronal nitric oxide synthase and inducible nitric oxide synthase-mediated nitric oxide production and translocation of nuclear factor-kappaB to nucleus.	Oxygen	123-129	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	33-54
29281280-3	2018	Our simulation results demonstrate that the binding of Gd3+ and UO22+ onto the oxygens of crown ethers is favorable for polystyrene grafted crown ether in the organic solvents OCT and NB.	Oxygen	79-86	GRDX	Homo sapiens	55-58
35496493-4	2022	The optimized structures of the reactants, intermediates and transition states involved in the reaction of the bicyclic peroxy radical with HO2 are shown.	Oxygen	120-134	heme oxygenase 2	Homo sapiens	140-143
35393410-8	2022	In NCMs, activation of BKCa channels increased the intracellular reactive oxygen species post HR injury.	Oxygen	74-80	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	23-27
29535830-4	2018	More importantly, NFATc3 deficient mice showed decreased neutrophilic lung inflammation, improved alveolar capillary barrier function, arterial oxygen saturation and survival benefit in lethal CLP sepsis mouse models.	Oxygen	144-150	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	Mus musculus	18-24
29278702-5	2018	In mouse insulinoma cell line 6 (MIN6), hypoxia (1% O2) primes the NLRP3 inflammasome along with NF-kappaB signaling activation.	Oxygen	52-54	NLR family, pyrin domain containing 3	Mus musculus	67-72
29655281-2	2018	Herein, it is demonstrated that strongly coupled carbon nanosheets/molybdenum carbide (alpha-MoC1-x ) nanocluster hierarchical hybrid hollow spheres (denoted as MoC1-x /HSC) can work well as cathode for boosting the performance of lithium-O2 batteries.	Oxygen	239-241	fucosyltransferase 1 (H blood group)	Homo sapiens	169-172
29655281-5	2018	The ex situ scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy studies reveal that the mechanism for the high-performance Li-O2 battery using MoC1-x /HSC as cathode is that the incorporated molybdenum carbide nanoclusters can make oxygen reduction on their surfaces easy, and finally form amorphous film-like Li-deficient Li2 O2 with the ability to decompose at a low potential.	Oxygen	266-272	fucosyltransferase 1 (H blood group)	Homo sapiens	185-188
35365193-3	2022	The carbonic anhydrase isoenzymes IX and XII (CA IX/XII), regulators of extra and intracellular pH, are overexpressed in TME and are involved in adaptative changes occurring in cancer cells to survive at low O2.	Oxygen	208-210	carbonic anhydrase 9	Mus musculus	46-55
32624938-5	2018	The oxygen mass transfer capability of a jet aerated loop reactor is discussed in terms of the volumetric oxygen mass transfer coefficient kLa [h-1] and the energetic oxygen transfer efficiency E [kgO2 kW-1 h-1].	Oxygen	4-10	H1.5 linker histone, cluster member	Homo sapiens	144-147
32624938-10	2018	For increased oxygen demands (above 120 mmol L-1 h-1) improved energetic oxygen transfer efficiencies of up to 100 % were found for a JLR compared to an aerated stirred tank reactor operating with Rushton turbines.	Oxygen	14-20	H1.5 linker histone, cluster member	Homo sapiens	49-52
32624938-10	2018	For increased oxygen demands (above 120 mmol L-1 h-1) improved energetic oxygen transfer efficiencies of up to 100 % were found for a JLR compared to an aerated stirred tank reactor operating with Rushton turbines.	Oxygen	73-79	H1.5 linker histone, cluster member	Homo sapiens	49-52
29849867-4	2018	Heme oxygenase-2 (HO-2) has been shown to be involved in oxygen sensing in several cell types.	Oxygen	5-11	heme oxygenase 2	Mus musculus	18-22
29849867-5	2018	The purpose of these experiments was to test the hypothesis that HO-2 is a critical regulator of mitochondrial oxygen consumption and reactive oxygen species (ROS) production to influence hypoxia-adaptive responses such as HIF-1alpha protein levels and JNK signaling.	Oxygen	111-117	heme oxygenase 2	Mus musculus	65-69
29849867-9	2018	Decreased oxygen consumption and increased mitochondrial ROS production in response to hypoxia were dependent upon HO-2 expression.	Oxygen	10-16	heme oxygenase 2	Mus musculus	115-119
29354636-1	2017	The human heme enzymes tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3 dioxygenase (hIDO) catalyze the initial step in L-tryptophan (L-Trp) catabolism, the insertion of dioxygen into L-Trp.	Oxygen	38-46	indoleamine 2,3-dioxygenase 1	Homo sapiens	90-94
29354636-6	2017	In hIDO, by contrast, dioxygen must first coordinate to the heme iron because a bound substrate would occlude ligand access to the heme iron, so the ternary complex can no longer form.	Oxygen	22-30	indoleamine 2,3-dioxygenase 1	Homo sapiens	3-7
29191924-6	2018	Our results showed that the neovascularization was decreased in both the CNV and oxygen-induced retinopathy models in HB-EGF conditional knockout mice compared with that in wild-type mice.	Oxygen	81-87	heparin-binding EGF-like growth factor	Mus musculus	118-124
29191924-7	2018	Moreover, the expressions of HB-EGF and VEGF were increased after laser-induced CNV and oxygen-induced retinopathy, and their expression sites were located around the neovascular areas.	Oxygen	88-94	heparin binding EGF like growth factor	Homo sapiens	29-35
35143076-8	2022	Both in vitro and in vivo results demonstrate that PBzyme reduces the activation of microglial NLRP3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating GSDMD cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis.	Oxygen	152-158	caspase 1	Mus musculus	119-128
30956387-3	2018	To study the strong effect of oxidation in air, a diffusion-based approach was applied to investigate the full interaction between fatigue and oxygen penetration at a crack tip.	Oxygen	143-149	TOR signaling pathway regulator	Homo sapiens	173-176
30956387-4	2018	Penetration of oxygen into the crack tip induced a local compressive stress due to dilatation effect.	Oxygen	15-21	TOR signaling pathway regulator	Homo sapiens	37-40
29606139-6	2018	It appears that Hif2alpha counteracts Hif1alpha and ROS-mediated protein deactivation under intermediate hypoxia and normoxia (20%), respectively, to regulate the response of cell cycle commitment to oxygen tension.	Oxygen	200-206	endothelial PAS domain protein 1	Homo sapiens	16-25
30956387-5	2018	An increase in stress intensity factor range or dwell times imposed at peak loads resulted in enhanced accumulation of oxygen at the crack tip.	Oxygen	119-125	TOR signaling pathway regulator	Homo sapiens	139-142
35236105-7	2022	In addition, retroviral-mediated overexpression of CDC6 rescued oxygen-induced retinopathy-induced retinal neovascularization from inhibition in PLCbeta3 knockout mice and in endothelial cell-specific NFATc1-deficient mice.	Oxygen	64-70	phospholipase C, beta 3	Mus musculus	145-153
29681326-5	2018	A conditioned placebo procedure was found to mimic the effects of oxygen on these compensatory responses, and these effects are still present at altitudes as high as 4500 and 5500m, where oxygen pressure is only 57% and 50%, respectively, compared to the sea level.	Oxygen	66-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	255-258
29524586-4	2018	Furthermore, HIF-1alpha and its regulation by PHDs, important oxygen sensors in the cell, provides a perfect drug target.	Oxygen	62-68	hypoxia inducible factor 1, alpha subunit	Mus musculus	13-23
35236105-8	2022	CONCLUSIONS: The above observations clearly reveal that PLCbeta3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.	Oxygen	148-154	phospholipase C, beta 3	Mus musculus	56-64
29373688-6	2018	Main Outcome Measure(s): We measured the activity of Jumonji domain containing protein 6 (JMJD6), a ferrous iron (Fe2+)- and oxygen-dependent histone demethylase, and examined its function in the epigenetic control of VHL.	Oxygen	125-131	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	90-95
35046512-7	2022	Accumulated studies have proposed mechanisms of renal damage and atherosclerosis in hyperuricemia, including inflammasome activation, decreased nitric oxide bioavailability and oxidative stress induced by uric acid, urate crystals and xanthine oxidoreductase (XOR)-mediated reactive oxygen species.	Oxygen	283-289	xanthine dehydrogenase	Homo sapiens	235-258
29680559-0	2018	High total organic carbon in surface waters of the northern Arabian Gulf: Implications for the oxygen minimum zone of the Arabian Sea.	Oxygen	95-101	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
28857429-8	2018	Additionally, annexin II expression was delineated in raw 264.7 macrophages under normal condition (20% O2 ) for 12 hrs or hypoxic condition (1% O2 ) for 6-12 hrs.	Oxygen	104-106	annexin A2	Homo sapiens	14-24
28857429-8	2018	Additionally, annexin II expression was delineated in raw 264.7 macrophages under normal condition (20% O2 ) for 12 hrs or hypoxic condition (1% O2 ) for 6-12 hrs.	Oxygen	145-147	annexin A2	Homo sapiens	14-24
35409227-5	2022	The timing of dynamic changes in O2 - and H2O2 was delayed for approximately three weeks in clv3-2, which has a longer lifespan.	Oxygen	33-37	CLAVATA3	Arabidopsis thaliana	92-96
29453322-1	2018	The mTOR signaling pathway is a central regulator of protein synthesis and cellular metabolism in response to the availability of energy, nutrients, oxygen, and growth factors.	Oxygen	149-155	mechanistic target of rapamycin kinase	Mus musculus	4-8
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	66-70
35498024-12	2022	Pharmacological blockade of NMDARs by the non-competitive NMDA antagonist MK-801 or knockdown of the glutamate receptor NR1 significantly attenuated the increased mitochondrial reactive oxygen species and calcium overload-induced by hypoxia exposure.	Oxygen	186-192	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	120-123
29378845-8	2018	Increased expression of Oma1 and Chop was paralleled by increased oxygen consumption and apoptosis susceptibility in ERalpha-KD cells.	Oxygen	66-72	OMA1 zinc metallopeptidase	Mus musculus	24-28
29378845-8	2018	Increased expression of Oma1 and Chop was paralleled by increased oxygen consumption and apoptosis susceptibility in ERalpha-KD cells.	Oxygen	66-72	DNA-damage inducible transcript 3	Mus musculus	33-37
29237750-5	2017	Nat1 KO mice also displayed reduced whole-body energy expenditure and reduced mitochondrial oxygen consumption in white adipose tissue, brown adipose tissue, and hepatocytes.	Oxygen	92-98	N-acetyl transferase 1	Mus musculus	0-4
29270287-13	2017	It also appeared that map2k1 and eif4b protein expression is altered in papillary RCC resistant to tested drugs at different oxygen tensions.	Oxygen	125-131	mitogen-activated protein kinase kinase 1	Homo sapiens	22-28
29983448-7	2018	The metastable species HOC, the oxygen analogue of HSC, has not been yet observed in space.	Oxygen	32-38	fucosyltransferase 1 (H blood group)	Homo sapiens	51-54
29535446-5	2018	This report shows that the cause of insufficient EPO production in AOP is elevated renal oxygen levels due to poor oxygen consumption by immature tubules.	Oxygen	89-95	erythropoietin	Mus musculus	49-52
29535446-5	2018	This report shows that the cause of insufficient EPO production in AOP is elevated renal oxygen levels due to poor oxygen consumption by immature tubules.	Oxygen	115-121	erythropoietin	Mus musculus	49-52
29535446-10	2018	These data suggest that tubular maturation with increased oxygen consumption is required for renal EPO production.	Oxygen	58-64	erythropoietin	Mus musculus	99-102
35424902-3	2022	Complete deactivation of spike protein binding to the human ACE2 protein was observed within an exposure time of 5 minutes which is correlated to the higher concentration of hydrogen peroxide formation due to the interaction with the reactive oxygen species present in the plasma.	Oxygen	243-249	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	25-30
29384648-0	2018	Well-Coupled Nanohybrids Obtained by Component-Controlled Synthesis and in Situ Integration of Mn xPd y Nanocrystals on Vulcan Carbon for Electrocatalytic Oxygen Reduction.	Oxygen	155-161	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	98-101
29192706-6	2017	The superoxide anion (O2-) that has been identified on an under-coordinated Au site has a larger polarizability than the MOx species and a mu0 that is opposite in sign to those of the metal MO2 species, which results in larger errors by the first-order approximation, although its stability varies only moderately under positive electric fields of up to 0.4 V A-1.	Oxygen	22-24	monooxygenase DBH like 1	Homo sapiens	121-124
29206844-0	2017	Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2alpha expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.	Oxygen	55-61	endothelial PAS domain protein 1	Homo sapiens	113-122
35424902-3	2022	Complete deactivation of spike protein binding to the human ACE2 protein was observed within an exposure time of 5 minutes which is correlated to the higher concentration of hydrogen peroxide formation due to the interaction with the reactive oxygen species present in the plasma.	Oxygen	243-249	angiotensin converting enzyme 2	Homo sapiens	60-64
29206844-5	2017	Since epigenetic silencing of the prolyl-hydroxylase-domain-3 (PHD3) enzyme responsible for the O2-dependent regulation of HIF2alpha is frequently observed in MM tumors, we asked if PHD3 plays a role in regulating sensitivity to hypoxia.	Oxygen	96-98	endothelial PAS domain protein 1	Homo sapiens	123-132
29507344-9	2018	Physiological relevance of our findings was asserted in a mouse model of oxygen-induced retinopathy, where the beneficial anti-angiogenic properties of CLCF1 were abrogated when co-administrated with VLDL, indicating, that CLCF1 binds purified lipoproteins or lipoproteins in physiological fluids such as serum and behave as a "lipocytokine".	Oxygen	73-79	cardiotrophin-like cytokine factor 1	Mus musculus	152-157
35157972-0	2022	Periostin attenuates oxygen and glucose deprivation-induced death of mouse neural stem cells via inhibition of p38 MAPK activation.	Oxygen	21-27	mitogen-activated protein kinase 14	Mus musculus	111-119
28877871-2	2017	To investigate the shift in metabolic control, especially between oxygen and metabolism, researchers often depend on near-infrared spectroscopy (NIRS) to measure noninvasively the tissue O2 Because NIRS detects the overlapping myoglobin (Mb) and hemoglobin (Hb) signals in muscle, interpreting the data as an index of cellular or vascular O2 requires deconvoluting the relative contribution.	Oxygen	66-72	myoglobin	Homo sapiens	227-236
28877871-2	2017	To investigate the shift in metabolic control, especially between oxygen and metabolism, researchers often depend on near-infrared spectroscopy (NIRS) to measure noninvasively the tissue O2 Because NIRS detects the overlapping myoglobin (Mb) and hemoglobin (Hb) signals in muscle, interpreting the data as an index of cellular or vascular O2 requires deconvoluting the relative contribution.	Oxygen	187-189	myoglobin	Homo sapiens	227-236
35194631-3	2022	Alkylation at oxygen x blocks the formation of NRx and RANxy but barely changes the spectra of all other structurally possible radical isomers.	Oxygen	14-20	nucleoredoxin	Homo sapiens	47-50
28877871-2	2017	To investigate the shift in metabolic control, especially between oxygen and metabolism, researchers often depend on near-infrared spectroscopy (NIRS) to measure noninvasively the tissue O2 Because NIRS detects the overlapping myoglobin (Mb) and hemoglobin (Hb) signals in muscle, interpreting the data as an index of cellular or vascular O2 requires deconvoluting the relative contribution.	Oxygen	339-341	myoglobin	Homo sapiens	227-236
35194631-4	2022	Through systematic comparison, this allowed unambiguous radical identification and spectral assignment by experiment in all cases: NR3 is preferred over NR4", all other NRx are negligible; NR3 and NR4" are deprotonated at oxygens 4" and 3", respectively, unless barred by substitution, or at oxygen 7.	Oxygen	222-229	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	189-192
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Oxygen	53-59	KN motif and ankyrin repeat domains 3	Homo sapiens	20-25
35194631-4	2022	Through systematic comparison, this allowed unambiguous radical identification and spectral assignment by experiment in all cases: NR3 is preferred over NR4", all other NRx are negligible; NR3 and NR4" are deprotonated at oxygens 4" and 3", respectively, unless barred by substitution, or at oxygen 7.	Oxygen	292-298	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	189-192
29047187-7	2018	Interestingly, such effects of KANK3 were not observed under hypoxic conditions, suggesting oxygen-dependent activity of KANK3.	Oxygen	92-98	KN motif and ankyrin repeat domains 3	Homo sapiens	31-36
29047187-7	2018	Interestingly, such effects of KANK3 were not observed under hypoxic conditions, suggesting oxygen-dependent activity of KANK3.	Oxygen	92-98	KN motif and ankyrin repeat domains 3	Homo sapiens	121-126
29047187-8	2018	Based on these data, we propose that KANK3 acts as a tumor suppressor to control cancer behavior in an oxygen-dependent manner.	Oxygen	103-109	KN motif and ankyrin repeat domains 3	Homo sapiens	37-42
35269533-3	2022	Unlike nNOS (-) cells, nNOS (+) neurons fail to generate reactive oxygen species in response to NMDAR activation, a critical divergent step in the excitotoxic cascade.	Oxygen	66-72	nitric oxide synthase 1	Homo sapiens	23-27
29311623-8	2018	Lastly, we show that transient exposure of wild-type MSCs to 21% oxygen upregulates p53 protein expression, resulting in increased mitochondrial ROS production and enhanced adipogenic differentiation at the expense of osteogenesis, and that treatment of cells with FGF2 mitigates these effects by inducing TWIST2.	Oxygen	65-71	transformation related protein 53, pseudogene	Mus musculus	84-87
29311623-9	2018	Together, these findings indicate that basal p53 levels are necessary to maintain MSC bi-potency, and oxygen-induced increases in p53 expression modulate cell fate and survival decisions.	Oxygen	102-108	transformation related protein 53, pseudogene	Mus musculus	130-133
29133078-18	2018	Addition of hREG3A to bacterial cultures reduced levels of ROS and increased survival of oxygen-sensitive commensal bacteria (Faecalibacterium prausnitzii and Roseburia intestinalis).	Oxygen	89-95	regenerating family member 3 alpha	Homo sapiens	12-18
29111638-3	2017	Here, amorphous Cox-Fe-B (x is the molar ratio of Co/Fe), Co-B, and Fe-B compounds were successfully synthesized as the oxygen evolution electrocatalysts.	Oxygen	120-126	metabolism of cobalamin associated B	Homo sapiens	58-62
29151322-1	2017	EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen.	Oxygen	109-115	epidermal growth factor	Homo sapiens	0-3
28863942-4	2017	Conversely, isolates from young (4 months) APP/PSEN1 mice consumed more oxygen, and exhibited an increase in mitochondrial membrane potential, but had a significantly lower ATP/ADP ratio compared to wild type isolates.	Oxygen	72-78	presenilin 1	Mus musculus	47-52
35246033-0	2022	Correction to: Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.	Oxygen	26-32	FERM domain containing kindlin 1	Rattus norvegicus	112-121
28849166-12	2017	EPO and MPSS effectively inhibited the oxygen and glucose deprivation-mediated downregulation of AQP4 following reperfusion.	Oxygen	39-45	erythropoietin	Rattus norvegicus	0-3
28849166-12	2017	EPO and MPSS effectively inhibited the oxygen and glucose deprivation-mediated downregulation of AQP4 following reperfusion.	Oxygen	39-45	aquaporin 4	Rattus norvegicus	97-101
29414037-6	2018	The more stability of [Fe-P1]2+ was attributed to an intramolecular hydrogen bond formation between the hydrogen atom of NH group and the oxygen atom of CH2OH chain.	Oxygen	138-144	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	26-28
28714140-7	2018	Physiologically low oxygen (2% O2 ) was introduced during the 7 day hMSC culture to preserve the stemness of hMSCs and thereby their capability to secrete angiogenic factors.	Oxygen	20-26	musculin	Homo sapiens	68-72
28714140-7	2018	Physiologically low oxygen (2% O2 ) was introduced during the 7 day hMSC culture to preserve the stemness of hMSCs and thereby their capability to secrete angiogenic factors.	Oxygen	31-33	musculin	Homo sapiens	68-72
35492279-4	2022	A chair-like Cu3O3 structure is generated in which the two CuO4N units are connected by one mu2-O ethano-late oxygen atom.	Oxygen	110-116	adaptor related protein complex 1 subunit mu 2	Homo sapiens	92-95
29497053-1	2018	Hydrogen sulfide (H2S, 80 ppm) gas in an atmosphere of 17.5% oxygen reportedly induces suspended animation in mice; a state analogous to hibernation that entails hypothermia and hypometabolism.	Oxygen	61-67	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	18-21
29285257-8	2017	However, the cross linking activity of HSP27 disappeared by quinolone compounds and the sensitizing effects on the anticancer drugs disappeared as well, suggesting oxygene moiety of 4-pyron structure of J2 may be a pharmacophore for induction of cross linking of HSP27 and sensitization to cancer cells.	Oxygen	164-171	heat shock protein family B (small) member 1	Homo sapiens	39-44
29085018-5	2017	Moreover, in photosystem II electron donor side, electron transport from oxygen evolution complex (OEC) to Yz residue of D1 protein was inhibited under high Cd2+ treatments, which may be due to the Cd2+ induced ROS production and the replacement of Ca2+ in the core of OEC.	Oxygen	73-79	CD2 molecule	Homo sapiens	157-160
35007518-5	2022	Secretion of trehalase that is essential for chitin synthesis and the release of hypoxia up-regulated protein to ameliorate oxygen deprivation help ensure normal transition from larva to pupa.	Oxygen	124-130	trehalase	Homo sapiens	13-22
29085018-5	2017	Moreover, in photosystem II electron donor side, electron transport from oxygen evolution complex (OEC) to Yz residue of D1 protein was inhibited under high Cd2+ treatments, which may be due to the Cd2+ induced ROS production and the replacement of Ca2+ in the core of OEC.	Oxygen	73-79	CD2 molecule	Homo sapiens	198-201
29489822-1	2018	Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell.	Oxygen	161-167	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	103-107
35091110-13	2022	It seems that in carriers of 1166C at1r, the severity of COVID-19 and oxygen dependency is higher as compared to the A allele carriers, possibly, due to cardiovascular disorders.	Oxygen	70-76	angiotensin II receptor type 1	Homo sapiens	35-39
29472561-6	2018	The autonomous transport role for MPC2 is validated in cells when the ectopic expression of human MPC2 in yeast lacking endogenous MPC stimulated growth and increased oxygen consumption.	Oxygen	167-173	mitochondrial pyruvate carrier 2	Homo sapiens	34-38
28558965-3	2017	The two electrons liberated are then passed to molecular oxygen by the renalase FAD cofactor forming hydrogen peroxide.	Oxygen	57-63	renalase, FAD dependent amine oxidase	Homo sapiens	71-79
29472561-6	2018	The autonomous transport role for MPC2 is validated in cells when the ectopic expression of human MPC2 in yeast lacking endogenous MPC stimulated growth and increased oxygen consumption.	Oxygen	167-173	mitochondrial pyruvate carrier 2	Homo sapiens	98-102
35269082-0	2022	Research on Atomic Oxygen Erosion Influence of Structural Damage and Tribological Properties of Mo/MoS2-Pb-PbS Thin Film.	Oxygen	19-25	cholinergic receptor muscarinic 3	Homo sapiens	107-110
28952645-4	2017	The significant structural differences between the two isomers, as revealed by the solid-state structures, derives from the regiospecific cleavage of one of the three Os-Os bonds in the intermediate alkenyl cluster Os3(CO)9(mu-C7H4NS)(eta1-EtO2CCCHCO2Et), which follows hydride transfer to the coordinated alkyne ligand in the pi compound HOs3(CO)9(mu-C7H4NS)(eta2-DEAD).	Oxygen	167-172	secreted phosphoprotein 1	Homo sapiens	235-239
35269082-1	2022	To investigate atomic oxygen effects on tribological properties of Mo/MoS2-Pb-PbS film and further enlarge application range, atomic oxygen exposure tests were carried out for 5 h, 10 h, 15 h, and 20 h by the atomic oxygen simulator with atomic oxygen flux of 2.5 x 1015 atoms/cm2 s. The exposure time in test was equivalent to the atomic oxygen cumulative flux for 159.25 h, 318.5 h, 477.75 h, and 637 h at the height of 400 km in space.	Oxygen	22-28	cholinergic receptor muscarinic 3	Homo sapiens	78-81
29186571-5	2018	We demonstrate that the activities of Tet enzymes display distinct patterns of [O2]-dependency, and that Tet1 activity, specifically, is subject to differential regulation within a range of O2 which is physiologically relevant in embryogenesis.	Oxygen	190-192	tet methylcytosine dioxygenase 1	Homo sapiens	105-109
35269082-3	2022	By SEM, TEM, and XPS analysis of the surface of the film after atomic oxygen erosion, it was observed that atomic oxygen could cause serious oxidation on the surface of Mo/MoS2-Pb-PbS film, and the contents of MoS2, PbS, and Pb, which were lubricating components, were significantly reduced, and oxides were generated.	Oxygen	70-76	cholinergic receptor muscarinic 3	Homo sapiens	180-183
35233019-3	2022	This chemical decomposition was performed through two types of hydrolysis reactions, that is, a hydrolysis reaction between OH- ions or R-NH3+ (i.e., EDA with a positively charged amine groups) and oxygen atoms covalently bonded with pyromellitimide on the PI-film-surface.	Oxygen	198-204	ectodysplasin A	Homo sapiens	150-153
28994107-6	2018	Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts.	Oxygen	62-64	vimentin	Homo sapiens	125-133
29065330-7	2018	These results also demonstrated the notable influence of air, oxygen, and the saline medium in HCN polymer formation.	Oxygen	62-68	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	95-98
29643975-4	2018	In this study, we found that physiological hypoxia (10% O2) enhanced the stemness properties and promoted the proliferation ability of iHepSCs by accelerating G1/S transition via p53-p21 signaling pathway.	Oxygen	56-58	H3 histone pseudogene 16	Homo sapiens	183-186
28936508-1	2017	The oxidative carbonylation of ToMCoMe (1; ToM = tris(4,4-dimethyl-2-oxazolinyl)phenylborate) involves its rapid, reversible reaction with CO to form ToMCo{C(O)Me}CO (2) followed by rapid reaction with O2 yielding ToMCoOAc (3), in contrast to the slow direct carboxylation of ToMCoMe by CO2.	Oxygen	202-204	pre-mRNA processing factor 6	Homo sapiens	31-34
28936873-8	2017	Finally, the products of Rox(III) degradation were identified as As(III) and 2-nitrohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxygen into the carbon and the other to the arsenic to catalyze cleavage of the C-As bond.	Oxygen	129-135	arylsulfatase family member I	Homo sapiens	117-121
28936873-8	2017	Finally, the products of Rox(III) degradation were identified as As(III) and 2-nitrohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxygen into the carbon and the other to the arsenic to catalyze cleavage of the C-As bond.	Oxygen	127-135	arylsulfatase family member I	Homo sapiens	117-121
28731464-1	2017	Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling.	Oxygen	41-47	heparin binding EGF like growth factor	Homo sapiens	130-135
28731464-6	2017	Proximity ligation assays demonstrated interactions between HSP70 and MMP2, and between MMP2 and HBEGF, supporting the concept that MMP2-mediated shedding of HBEGF, initiated by HSP70, contributes to trophoblast survival at the low O2 concentrations encountered during the first trimester, and is essential for successful pregnancy outcomes.	Oxygen	232-234	heparin binding EGF like growth factor	Homo sapiens	158-163
28374977-4	2017	Autophagy of CD34+ VEGFR-2+ EPCs isolated from rat bone marrow increased after treatment with 1% O2 .	Oxygen	97-99	kinase insert domain receptor	Rattus norvegicus	19-26
35136059-5	2022	Action potential and calcium oscillation frequencies are increased in Insr knockout beta-cells from female, but not male mice, whereas only male betaInsrKO islets have reduced ATP-coupled oxygen consumption rate and reduced expression of genes involved in ATP synthesis.	Oxygen	188-194	insulin receptor	Mus musculus	70-74
28772282-6	2017	Blocking the oxygen-binding site of HBB reverts the increase of migration and HIF-1alpha upregulation observed in HBB-overexpressing breast cancer cells.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-88
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Oxygen	73-79	microRNA 33a	Homo sapiens	43-49
29308820-3	2018	The S-nitrosylation detection and subsequent kinetic investigations into the arachidonic acid (AA) oxidation of COX enzymes indicate that NO S-nitrosylates both COX-1 and COX-2 in an oxygen-dependent manner, but enhances only the dioxygenase activity of COX-2.	Oxygen	183-189	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	161-166
35163779-13	2022	Compared to those of NT, TFAM-KD-C had not only a lower mtDNA copy number (p = 0.050), but also lower oxygen consumption rates (OCR), including basal respiration (OCRBR), ATP-coupled respiration (OCRATP), reserve capacity (OCRRC), and proton leak (OCRPL)(all with p = 0.050).	Oxygen	102-108	transcription factor A, mitochondrial	Mus musculus	25-29
29497482-11	2017	In MDA-MB-231 cells high fractional oxygen increased secretion of angiogenesis factors monocyte chemotactic protein 1, regulated on activation normal T-cell expressed and vascular endothelial growth factor.	Oxygen	36-42	C-C motif chemokine ligand 2	Homo sapiens	87-117
28426331-7	2017	In addition, the results of low oxygen condition fermentation showed that deletion of bdhA gene successfully blocked the reversible transformation between acetoin and 2,3-butanediol and eliminated the effect of dissolved oxygen on the transformation.	Oxygen	32-38	acetoin reductase/2,3-butanediol dehydrogenase	Bacillus subtilis subsp. subtilis str. 168	86-90
35102488-4	2022	The anticancer effects of HPCAL1 knockdown were determined by MTT, soft agar, cell cycle, oxygen consumption and reactive oxygen species assays.	Oxygen	90-96	hippocalcin like 1	Homo sapiens	26-32
28853487-5	2017	Further experiments and analysis revealed that oxygen vacancies can be well regulated by the combined current effect and temperature cycling in repeated measurements, which results in a decrease of Co4+/Co3+ and thus the remarkable variation of conductive properties of the film.	Oxygen	47-53	complement C4A (Rodgers blood group)	Homo sapiens	198-201
29345616-5	2018	Using behavioral functional screening, we pinpoint that expression of the mitochondrial reactive oxygen scavenger SOD2 in cholinergic projection neurons is necessary and sufficient to prevent smell degeneration in aging flies.	Oxygen	97-103	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	114-118
29128272-9	2018	LA and STX+LA treatments induced low reactive oxygen species levels and low oxygen consumption.	Oxygen	46-52	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	7-10
35102488-9	2022	Knockdown of HPCAL1 strongly increased oxygen consumption rates and the production of reactive oxygen species.	Oxygen	39-45	hippocalcin like 1	Homo sapiens	13-19
28412161-1	2017	OBJECTIVES: We sought to examine the physiological impact the apneic period has on the respiratory physiology of patients undergoing intubation in the emergency department and whether DAO, the delivery of 15L oxygen by nasal cannula during apnea, can affect the development of respiratory acidosis.	Oxygen	209-215	D-amino acid oxidase	Homo sapiens	184-187
35102488-9	2022	Knockdown of HPCAL1 strongly increased oxygen consumption rates and the production of reactive oxygen species.	Oxygen	95-101	hippocalcin like 1	Homo sapiens	13-19
35163456-3	2022	We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear.	Oxygen	80-86	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	44-49
28644693-0	2017	Supplemental Oxygen in Interstitial Lung Disease: An Art in Need of Science.	Oxygen	13-19	artemin	Homo sapiens	53-56
29317607-6	2018	The miR-3473b antagomir also decreased the expression of pro-inflammatory factors in BV2 cells activated with conditioned medium collected from oxygen-glucose deprivation (OGD)-treated neurons.	Oxygen	144-150	microRNA 3473b	Mus musculus	4-13
35163456-3	2022	We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear.	Oxygen	80-86	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	212-217
29084012-1	2018	BACKGROUND: Cerebral oximetry (cerebral oxygen saturation; ScO2) is used to noninvasively monitor cerebral oxygenation.	Oxygen	40-46	synthesis of cytochrome C oxidase 2	Homo sapiens	59-63
29247136-0	2018	BET 1: Continuous flow insufflation of oxygen in out-of-hospital cardiac arrest.	Oxygen	39-45	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	0-5
28779427-9	2017	The study also displayed that dissolved oxygen levels at the outlet were significantly (p &lt; 0.001) higher after passing into the EDD system.	Oxygen	40-46	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	132-135
28715154-4	2017	We found that 2-h hypoxia (8% O2 ) and the intraperitoneal injection of 4 mg kg-1 lipopolysaccharide (LPS) causes the appearance of AKI markers, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the rat urine after 24 and 72 h of exposure.	Oxygen	30-32	hepatitis A virus cellular receptor 1	Rattus norvegicus	153-177
28715154-4	2017	We found that 2-h hypoxia (8% O2 ) and the intraperitoneal injection of 4 mg kg-1 lipopolysaccharide (LPS) causes the appearance of AKI markers, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the rat urine after 24 and 72 h of exposure.	Oxygen	30-32	hepatitis A virus cellular receptor 1	Rattus norvegicus	179-184
35163088-2	2022	Evidence has been obtained from mice and human cancer patients with bony metastases and non-metastatic disease, as well as pediatric burn patients, that inflammation leads to bone resorption and release of TGF-beta from the bone matrix with paracrine effects on muscle protein balance, possibly mediated by the generation of reactive oxygen species.	Oxygen	334-340	transforming growth factor alpha	Homo sapiens	206-214
28862673-10	2017	Myoglobin mRNA expression increased by 75% under 5% O2 but decreased by 50% upon IGF-1 treatment under 20% O2, compared to control.	Oxygen	52-54	myoglobin	Homo sapiens	0-9
28862673-10	2017	Myoglobin mRNA expression increased by 75% under 5% O2 but decreased by 50% upon IGF-1 treatment under 20% O2, compared to control.	Oxygen	107-109	myoglobin	Homo sapiens	0-9
29098589-6	2018	Biochemical oxygen demand and orthophosphates concentrations achieved a good water quality status according to the European Legislation for scenarios of BMP applied to 3 and 12% agricultural area, respectively.	Oxygen	12-18	bone morphogenetic protein 1	Homo sapiens	153-156
35087615-0	2022	G-Protein Coupled Receptor 35 Induces Intervertebral Disc Degeneration by Mediating the Influx of Calcium Ions and Upregulating Reactive Oxygen Species.	Oxygen	137-143	G protein-coupled receptor 35	Homo sapiens	0-29
29034529-12	2018	Moreover, an mBF/mVO2 muscle oxygen consumption ratio of ~5 was consistent for all exercise stages.	Oxygen	29-35	rhotekin 2	Mus musculus	13-16
29132019-1	2018	Oxygen homeostasis in normal and tumor cells is mediated by hypoxia-inducible factors (HIFs), which are active as heterodimer complexes, such as HIF-2alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-1alpha-ARNT.	Oxygen	0-6	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	145-202
29132019-1	2018	Oxygen homeostasis in normal and tumor cells is mediated by hypoxia-inducible factors (HIFs), which are active as heterodimer complexes, such as HIF-2alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-1alpha-ARNT.	Oxygen	0-6	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	204-208
29132019-1	2018	Oxygen homeostasis in normal and tumor cells is mediated by hypoxia-inducible factors (HIFs), which are active as heterodimer complexes, such as HIF-2alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-1alpha-ARNT.	Oxygen	0-6	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	225-229
30356600-0	2017	Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players.	Oxygen	125-131	insulin like growth factor binding protein 1	Homo sapiens	56-100
28326554-7	2017	In parallel to the wild-type, the LHCSR3-deficient npq4 mutant was high light-treated, which in photoautotrophic conditions exhibited particular sensitivity under elevated oxygen, the treatment that induced the highest RES levels, including acrolein.	Oxygen	172-178	uncharacterized protein	Chlamydomonas reinhardtii	34-40
35042744-3	2022	The most well-studied oxygen response pathway involves hypoxia-inducible factors (HIF) and their regulation by the von Hippel-Lindau protein (pVHL) and the prolyl hydroxylases (PHD1-3).	Oxygen	22-28	von Hippel-Lindau tumor suppressor	Homo sapiens	142-146
28741347-5	2017	Of these probes, FBN-1 showed excellent sensitivity and selectivity in detecting hypoxia via a reduction in O2 concentration.	Oxygen	108-110	fibrillin 1	Homo sapiens	17-22
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	41-45
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	66-70
28741347-6	2017	Confocal fluorescence imaging and flow cytometry demonstrated that HepG-2, A549, and SKOV-3 cells incubated with FBN-1 under reduced oxygen conditions showed significantly enhanced fluorescence.	Oxygen	133-139	fibrillin 1	Homo sapiens	113-118
35042744-3	2022	The most well-studied oxygen response pathway involves hypoxia-inducible factors (HIF) and their regulation by the von Hippel-Lindau protein (pVHL) and the prolyl hydroxylases (PHD1-3).	Oxygen	22-28	egl-9 family hypoxia inducible factor 2	Homo sapiens	177-183
35069734-10	2022	In addition, we found that, in PANC-1 cells under an acidic environment, miR-451a overexpression enhanced oxygen consumption, mitochondrial membrane potential (MMP) loss, and ROS generation and inhibited proliferation, migration, invasion, and stemness via sponging MEF2D.	Oxygen	106-112	microRNA 451a	Homo sapiens	73-81
29100382-2	2017	The aim of this study is to identify whether salubrinal could attenuate RNV by inhibiting CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP)- hypoxia inducible factors 1alpha (HIF1alpha) -vascular endothelial growth factor (VEGF) pathways in both mouse retinal microvascular endothelial cells (mRMECs) and oxygen-induced retinopathy (OIR) mouse model.	Oxygen	320-326	DNA-damage inducible transcript 3	Mus musculus	149-153
28668175-2	2018	Haemoglobin and myoglobin are haem proteins that play a key role as they help transport oxygen around the body.	Oxygen	88-94	myoglobin	Homo sapiens	16-25
29168340-10	2018	Oxygen exposure also significantly decreased E-cadherin expression and induced expression of the SNAI1 transcription factor in vivo and in vitro.	Oxygen	0-6	cadherin 1	Rattus norvegicus	45-55
29168340-10	2018	Oxygen exposure also significantly decreased E-cadherin expression and induced expression of the SNAI1 transcription factor in vivo and in vitro.	Oxygen	0-6	snail family transcriptional repressor 1	Rattus norvegicus	97-102
34499172-6	2022	Based on the high levels of H2O2 found in opt3-2 we propose a model where reactive oxygen species prevent the induction of genes that are induced in wildtype by either Fe deficiency or Cd.	Oxygen	83-89	oligopeptide transporter	Arabidopsis thaliana	42-46
29325335-6	2017	Additionally, after adjustment for BMI and age, serum A-FABP level showed significant positive correlations with FINS and IRI (r=0.478, P&lt;0.001; r=0.356, P=0.035); serum A-FABP level was positively correlated with AHI and the arterial oxygen saturation (SaO(2)) &lt; 90% time ratio in night (TS90%) (r=0.251, P=0.041 and r=0.271, P=0.035).	Oxygen	238-244	fatty acid binding protein 4	Homo sapiens	54-60
29199734-7	2017	Complex [Mo(O)2(QC6)2], 12, was obtained by treatment of 10 with one equivalent of PPh3, demonstrating that the first step in the epoxide deoxygenation mechanism was the oxygen atom transfer toward the phosphane.	Oxygen	140-146	protein phosphatase 4 catalytic subunit	Homo sapiens	83-87
28625985-13	2017	Bacteria usually decompose nicotine using the classical strategy of hydroxylating the pyridine ring with the help of activated oxygen by nicotine dehydrogenase, which binds one molybdopterin, two [2Fe2S] clusters, and usually one flavin adenine dinucleotide (FAD) as well.	Oxygen	127-133	hydroxyacid dehydrogenase	Agrobacterium tumefaciens	146-159
28726380-3	2017	Surface-interrogation scanning electrochemical microscopy (SI-SECM) revealed that CoP HER catalyst is vulnerable to oxidation (by oxygen and chemical oxidants).	Oxygen	130-136	caspase recruitment domain family member 16	Homo sapiens	82-85
28813675-6	2017	Our data indicate that the stem cell marker CD44 modulates the hypoxic response of glioma cells and that the pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2alpha through interaction with CD44, independently of oxygen.	Oxygen	251-257	endothelial PAS domain protein 1	Homo sapiens	192-202
29256392-3	2017	Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular lipolysis.	Oxygen	52-58	patatin like phospholipase domain containing 2	Homo sapiens	130-157
29256392-3	2017	Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular lipolysis.	Oxygen	52-58	patatin like phospholipase domain containing 2	Homo sapiens	159-163
35018216-0	2022	Oxygen-independent, CDK4/CDK6-dependent degradation of hypoxia-inducible factor-1alpha takes cancers" breath away.	Oxygen	0-6	cyclin dependent kinase 4	Homo sapiens	20-24
29270287-13	2017	It also appeared that map2k1 and eif4b protein expression is altered in papillary RCC resistant to tested drugs at different oxygen tensions.	Oxygen	125-131	eukaryotic translation initiation factor 4B	Homo sapiens	33-38
28620066-4	2017	OBJECTIVES: To investigate the role of the pulmonary-specific isoform 2 of subunit 4 of the mitochondrial complex IV (Cox4i2) and the subsequent mediators superoxide and hydrogen peroxide for pulmonary oxygen sensing and signaling.	Oxygen	202-208	cytochrome c oxidase subunit 4I2	Mus musculus	118-124
28620066-12	2017	CONCLUSIONS: Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization and release of mitochondrial superoxide which, after conversion to hydrogen peroxide, contributes to cellular membrane depolarization and HPV.	Oxygen	69-75	cytochrome c oxidase subunit 4I2	Mus musculus	13-19
29238035-4	2017	Besides, overexpression of miR-21 protects oxygen-glucose deprivation and reoxygenation (OGD/R)-induced apoptotic cell death.	Oxygen	43-49	microRNA 21	Homo sapiens	27-33
34981770-7	2022	The resulting neutron diffraction data permitted the visualization of a dioxygen species bound to the MnSOD active-site metal that was indicative of successful cryotrapping.	Oxygen	72-80	superoxide dismutase 2	Homo sapiens	102-107
29222479-4	2017	Alcohol directly enhanced GDF15 expression in primary hepatocytes, which led to increased oxygen consumption.	Oxygen	90-96	growth differentiation factor 15	Mus musculus	26-31
28779178-4	2017	Differential expression of energy metabolism genes, which indicated increased glucose utilization and decreased fatty acid utilization, were consistent with adaptive responses to perturbations of O2/CO2 balance in AE3-null myocytes.	Oxygen	196-198	solute carrier family 4 (anion exchanger), member 3	Mus musculus	214-217
28779178-5	2017	Given that the myocardium is an obligate aerobic tissue and consumes large amounts of O2, the data suggest that loss of AE3, which has the potential to extrude CO2 in the form of HCO3-, impairs O2/CO2 balance in cardiac myocytes.	Oxygen	86-88	solute carrier family 4 (anion exchanger), member 3	Mus musculus	120-123
28779178-5	2017	Given that the myocardium is an obligate aerobic tissue and consumes large amounts of O2, the data suggest that loss of AE3, which has the potential to extrude CO2 in the form of HCO3-, impairs O2/CO2 balance in cardiac myocytes.	Oxygen	161-163	solute carrier family 4 (anion exchanger), member 3	Mus musculus	120-123
35491020-4	2022	Complexation of ConA and CD206 with ligands is shown to be energetically caused by electrostatic interactions (E) of the charged residues (Asn, Asp, Arg) with oxygen and hydrogen atoms in carbohydrates; contributions of hydrophobic and van der Waals components is lower.	Oxygen	159-165	mannose receptor C-type 1	Homo sapiens	25-30
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Oxygen	41-47	adenosine A2a receptor	Homo sapiens	76-98
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Oxygen	41-47	adenosine A2a receptor	Homo sapiens	100-104
29053469-3	2017	The samples were subjected to thermal treatments under a reducing atmosphere of H2/Ar, to generate oxygen vacancies at the surface of the NWs.	Oxygen	99-105	H2A clustered histone 19	Homo sapiens	80-85
35002528-8	2022	Furthermore, NEU1 inhibition also attenuated the high glucose-induced increased reactive oxygen species generation, inflammation and, cell death in vitro.	Oxygen	89-95	neuraminidase 1	Mus musculus	13-17
29147009-1	2017	Ubiquinol cytochrome c reductase binding protein (UQCRB) is important for mitochondrial complex III stability, electron transport, cellular oxygen sensing and angiogenesis.	Oxygen	140-146	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	0-48
29147009-1	2017	Ubiquinol cytochrome c reductase binding protein (UQCRB) is important for mitochondrial complex III stability, electron transport, cellular oxygen sensing and angiogenesis.	Oxygen	140-146	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	50-55
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Oxygen	41-47	adenosine A2a receptor	Homo sapiens	164-168
35590466-4	2022	SARS-CoV-2 binds erythrocyte band3 protein, which has a similar characteristic of ACE2, leading to alteration of erythrocyte physiology like oxygen transport with development of hypoxia.	Oxygen	141-147	angiotensin converting enzyme 2	Homo sapiens	82-86
28547766-6	2017	Thus, local VEGF release near the transplanted cardiomyocytes induces vascularization, which supplies sufficient oxygen and nutrients to prevent necrosis.	Oxygen	113-119	vascular endothelial growth factor A	Rattus norvegicus	12-16
29135954-10	2017	The alkali metal cations, tetrabutylammonium (TBA+), Mg2+ and Ag+, interact with the C-2 carbonyl oxygen of the isatin anion.	Oxygen	98-104	complement C2	Homo sapiens	85-88
29152948-2	2017	In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	129-135	erythropoietin	Rattus norvegicus	53-57
35041287-0	2022	Li2 O2 Formation Electrochemistry and Its Influence on Oxygen Reduction/Evolution Reaction Kinetics in Aprotic Li-O2 Batteries.	Oxygen	55-61	ATP binding cassette subfamily A member 12	Homo sapiens	0-3
29290983-4	2017	Due to the chelating-coordinating effect between the lone-pair electrons of the PVP carbonyl oxygen and the unoccupied 4d orbitals of molybdenum, the PVP chains could graft onto the surface of MoS2 and guide the growth of the nanosheets.	Oxygen	93-99	mago homolog, exon junction complex core component	Mus musculus	193-197
29218237-5	2017	miR-21 increased lactate generation and decreased oxygen consumption in NSCLC cells.	Oxygen	50-56	microRNA 21	Homo sapiens	0-6
28342838-4	2017	A high concentration of oxygen in MAP and VSP+MAP affected protein oxidation, which was reflected in myosin oxidative cross-linking.	Oxygen	24-30	myosin heavy chain 14	Homo sapiens	101-107
35041287-5	2022	The first part of this review elaborates the Li2 O2 formation mechanism and its relationship with the oxygen reduction reaction/oxygen evolution reaction electrochemistry.	Oxygen	102-108	ATP binding cassette subfamily A member 12	Homo sapiens	45-48
35041287-5	2022	The first part of this review elaborates the Li2 O2 formation mechanism and its relationship with the oxygen reduction reaction/oxygen evolution reaction electrochemistry.	Oxygen	128-134	ATP binding cassette subfamily A member 12	Homo sapiens	45-48
28766032-2	2017	To address local hypoxia and to better understand direct cellular benefits, a perfluorocarbon conjugated chitosan (MACF) hydrogel that delivers oxygen was created and applied for the first time to in vitro cultures of human dermal fibroblasts and human epidermal keratinocytes under both normoxic (21% O2) and hypoxic (1% O2) environments.	Oxygen	144-150	microtubule actin crosslinking factor 1	Homo sapiens	115-119
28766032-2	2017	To address local hypoxia and to better understand direct cellular benefits, a perfluorocarbon conjugated chitosan (MACF) hydrogel that delivers oxygen was created and applied for the first time to in vitro cultures of human dermal fibroblasts and human epidermal keratinocytes under both normoxic (21% O2) and hypoxic (1% O2) environments.	Oxygen	302-304	microtubule actin crosslinking factor 1	Homo sapiens	115-119
35041287-9	2022	Further prospects of the ways in making advanced Li-O2 batteries by control of favorable Li2 O2 formation are highlighted, which are valuable for practical construction of aprotic lithium-oxygen batteries.	Oxygen	188-194	ATP binding cassette subfamily A member 12	Homo sapiens	89-92
28766032-2	2017	To address local hypoxia and to better understand direct cellular benefits, a perfluorocarbon conjugated chitosan (MACF) hydrogel that delivers oxygen was created and applied for the first time to in vitro cultures of human dermal fibroblasts and human epidermal keratinocytes under both normoxic (21% O2) and hypoxic (1% O2) environments.	Oxygen	322-324	microtubule actin crosslinking factor 1	Homo sapiens	115-119
2555360-12	1989	Secondary amine mono-oxygenase is unique in its ability to function as cytochrome P-450 in activating molecular oxygen but to do so with a myoglobin-like active site.	Oxygen	21-27	myoglobin	Homo sapiens	139-148
28766032-3	2017	Results revealed that local application of MACF provided 233.8 +- 9.9 mmHg oxygen partial pressure at 2 h and maintained equilibrium oxygen levels that were approximately 17 mmHg partial pressure greater than untreated controls.	Oxygen	75-81	microtubule actin crosslinking factor 1	Homo sapiens	43-47
28766032-3	2017	Results revealed that local application of MACF provided 233.8 +- 9.9 mmHg oxygen partial pressure at 2 h and maintained equilibrium oxygen levels that were approximately 17 mmHg partial pressure greater than untreated controls.	Oxygen	133-139	microtubule actin crosslinking factor 1	Homo sapiens	43-47
28766032-6	2017	In total, these studies provide new data to indicate that supplying local oxygen via MACF hydrogels under hypoxic environments improves key wound healing cellular functions.	Oxygen	74-80	microtubule actin crosslinking factor 1	Homo sapiens	85-89
28823591-6	2017	In vitro, overexpression of G6PD in cultured primary neurons decreased neuronal injury under oxygen and glucose deprivation/reoxygenation (OGD/R) condition, whereas knockdown of G6PD aggravated it.	Oxygen	93-99	glucose-6-phosphate dehydrogenase 2	Mus musculus	28-32
28802561-7	2017	RESULTS: We found that impaired alveolar development and aberrant elastin production were associated with elevations in whole lung elastase levels in 85% O2-exposed lungs.	Oxygen	154-156	elastin	Mus musculus	66-73
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	2-8	erythropoietin	Mus musculus	233-247
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	erythropoietin	Mus musculus	233-247
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	erythropoietin	Mus musculus	233-247
28472013-7	2017	However, reoxygenation with 100% oxygen and 21% oxygen significantly decreased BDNF mRNA levels compared with control air group.	Oxygen	11-17	brain derived neurotrophic factor	Mus musculus	79-83
28472013-7	2017	However, reoxygenation with 100% oxygen and 21% oxygen significantly decreased BDNF mRNA levels compared with control air group.	Oxygen	33-39	brain derived neurotrophic factor	Mus musculus	79-83
29068390-7	2017	Hence, it is often overlooked that hepcidin-secreting hepatocytes are physiologically exposed to 2-7% oxygen, and that key oxygen species such as H2O2 act as signaling messengers in such a hypoxic environment.	Oxygen	102-108	hepcidin antimicrobial peptide	Homo sapiens	35-43
29262585-5	2017	Using human retinal endothelial cells (HREC) exposed to hypoxia and a mouse model of oxygen-induced retinopathy (OIR), we found that TIMP3 expression was significantly decreased at both mRNA and protein levels and this paralleled the activation of STAT3 and up-regulation of miR-21.	Oxygen	85-91	tissue inhibitor of metalloproteinase 3	Mus musculus	133-138
28880555-1	2017	The proton affinity (PA) on the oxygen atom in silanol and siloxane derivatives is enhanced by the formation of tetrel bonds with small Lewis bases [B   R3SiOH, B   R3SiOSiR3, B   R3SiOSiR3   B; B = H2O, CO, NH3, HCN, H2S; R = H, Me], as shown by MP2/jul-cc-pVTZ calculations.	Oxygen	32-38	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	213-216
28880555-1	2017	The proton affinity (PA) on the oxygen atom in silanol and siloxane derivatives is enhanced by the formation of tetrel bonds with small Lewis bases [B   R3SiOH, B   R3SiOSiR3, B   R3SiOSiR3   B; B = H2O, CO, NH3, HCN, H2S; R = H, Me], as shown by MP2/jul-cc-pVTZ calculations.	Oxygen	32-38	tryptase pseudogene 1	Homo sapiens	247-250
28557543-9	2017	The Mcl-1 transgene increased oxygen consumption rates and mROS expression in mock-infected bone marrow-derived macrophages but reduced caspase-dependent mROS production after pneumococcal challenge.	Oxygen	30-36	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	4-9
28646017-5	2017	Here we showed that retinoic acid receptor-related orphan receptor alpha (RORalpha), a nuclear receptor and transcription factor, is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	229-235	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	Mus musculus	170-176
28791491-0	2017	Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model.	Oxygen	101-107	vascular endothelial growth factor A	Rattus norvegicus	8-12
28791491-1	2017	PURPOSE: We used a Laser speckle flowgraphy (LSFG)-micro system to examine the relationship between ocular blood flow and retinal vascular endothelial growth factor (VEGF) at retinopathy onset in oxygen-induced ischemic retinopathy (OIR) model rats.	Oxygen	196-202	vascular endothelial growth factor A	Rattus norvegicus	130-164
28791491-1	2017	PURPOSE: We used a Laser speckle flowgraphy (LSFG)-micro system to examine the relationship between ocular blood flow and retinal vascular endothelial growth factor (VEGF) at retinopathy onset in oxygen-induced ischemic retinopathy (OIR) model rats.	Oxygen	196-202	vascular endothelial growth factor A	Rattus norvegicus	166-170
28957413-6	2017	TERT-hBA adipocytes were UCP1-positive and responded to beta-adrenergic stimulation by activating the PKA-MKK3/6-p38 MAPK signaling module and increasing thermogenic gene expression and oxygen consumption.	Oxygen	186-192	telomerase reverse transcriptase	Homo sapiens	0-4
29062662-0	2017	Hyperbaric Oxygen Inhibits Reperfusion-Induced Neutrophil Polarization and Adhesion Via Plasmin-Mediated VEGF Release.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	105-109
28935964-4	2017	Using ex vivo on-line NO-detection, we showed that Mb is the strongest NR occurring in heart, which operates sufficiently only at very low oxygen levels.	Oxygen	139-145	myoglobin	Homo sapiens	51-53
27663883-3	2017	However, the possible role of NPY in regulating the effects of oxygen variation in lower vertebrates has not been investigated.	Oxygen	63-69	neuropeptide Y	Homo sapiens	30-33
27663883-4	2017	We have studied the distribution and neuro-anatomical expression of NPY in the brain of Euphlyctis cyanophlyctis tadpoles, exposed to normal and reduced oxygen levels using immunohistochemistry.	Oxygen	153-159	neuropeptide Y	Homo sapiens	68-71
28426331-7	2017	In addition, the results of low oxygen condition fermentation showed that deletion of bdhA gene successfully blocked the reversible transformation between acetoin and 2,3-butanediol and eliminated the effect of dissolved oxygen on the transformation.	Oxygen	221-227	acetoin reductase/2,3-butanediol dehydrogenase	Bacillus subtilis subsp. subtilis str. 168	86-90
28784706-0	2017	Photosynthetic oxygen production in a warmer ocean: the Sargasso Sea as a case study.	Oxygen	15-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
28784706-4	2017	Based on our own and published observations of water column processes in oligotrophic regions, we develop a one-dimensional water column model describing photosynthetic oxygen production in the Sargasso Sea to quantify the importance of photosynthesis for the downward flux of O2 and examine how it may be influenced in a warmer ocean.	Oxygen	169-175	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	203-206
28435049-0	2017	Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity.	Oxygen	38-44	insulin like growth factor binding protein 1	Homo sapiens	98-105
28620826-4	2017	Oxygen consumption was decreased by alpha-synuclein overexpression, but ATP levels did not decrease and ROS levels did not increase.	Oxygen	0-6	synuclein alpha	Homo sapiens	36-51
28927099-4	2017	Co-treatment of PC9 cells with gefitinib and hypoxia (1% O2) significantly enhanced adaptive resistance compared with gefitinib or hypoxia treatment alone.	Oxygen	57-59	proprotein convertase subtilisin/kexin type 9	Homo sapiens	16-19
28734156-0	2017	A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7.	Oxygen	43-49	coagulation factor III, tissue factor	Homo sapiens	72-85
28832580-6	2017	Loss of CD73-mediated extracellular adenosine production led to decreased survival with exposure to 95% oxygen, and exacerbated pulmonary inflammation and worsened lung development with 70% oxygen exposure.ConclusionExposure to hyperoxia causes lung injury associated with an increase in adenosine concentration, and loss of CD73-mediated adenosine production leads to worsening of hyperoxic lung injury.Pediatric Research advance online publication, 23 August 2017; doi:10.1038/pr.2017.176.	Oxygen	104-110	5' nucleotidase, ecto	Mus musculus	8-12
28832580-6	2017	Loss of CD73-mediated extracellular adenosine production led to decreased survival with exposure to 95% oxygen, and exacerbated pulmonary inflammation and worsened lung development with 70% oxygen exposure.ConclusionExposure to hyperoxia causes lung injury associated with an increase in adenosine concentration, and loss of CD73-mediated adenosine production leads to worsening of hyperoxic lung injury.Pediatric Research advance online publication, 23 August 2017; doi:10.1038/pr.2017.176.	Oxygen	190-196	5' nucleotidase, ecto	Mus musculus	8-12
28819234-5	2017	Second, Dbx1 preBotC neurons express the hypoxia-inducible transcription factor Hif1a at levels three-times higher than non-Dbx1 neurons, which links core rhythmogenic microcircuits to O2-related chemosensation for the first time.	Oxygen	185-187	hypoxia inducible factor 1, alpha subunit	Mus musculus	80-85
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Oxygen	138-144	growth factor, augmenter of liver regeneration	Homo sapiens	330-333
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Oxygen	138-144	growth factor, augmenter of liver regeneration	Homo sapiens	339-342
27958690-5	2017	RESULTS: After 3 months, patients receiving G-CSF reported increased subjective relief of symptoms and showed increased transcutaneous oxygen tension (TcPO2).	Oxygen	135-141	colony stimulating factor 3	Homo sapiens	44-49
28410532-4	2017	Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, which was recued by BMI-1 silencing.	Oxygen	36-42	POU class 5 homeobox 1	Homo sapiens	81-85
28410532-4	2017	Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, which was recued by BMI-1 silencing.	Oxygen	36-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
28728562-9	2017	Immunofluorescence showed that the intensity of staining for HIF-2alpha, MnSOD and LIFR were higher in 3% O2.	Oxygen	106-108	endothelial PAS domain protein 1	Mus musculus	61-71
28728562-9	2017	Immunofluorescence showed that the intensity of staining for HIF-2alpha, MnSOD and LIFR were higher in 3% O2.	Oxygen	106-108	LIF receptor alpha	Mus musculus	83-87
28608669-0	2017	One-pot Synthesis of CdS Irregular Nanospheres Hybridized with Oxygen-Incorporated Defect-Rich MoS2 Ultrathin Nanosheets for Efficient Photocatalytic Hydrogen Evolution.	Oxygen	63-69	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
28608669-1	2017	Robust and highly active photocatalysts, CdS@MoS2, for hydrogen evolution were successfully fabricated by one-step growth of oxygen-incorporated defect-rich MoS2 ultrathin nanosheets on the surfaces of CdS with irregular fissures.	Oxygen	125-131	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
28608669-1	2017	Robust and highly active photocatalysts, CdS@MoS2, for hydrogen evolution were successfully fabricated by one-step growth of oxygen-incorporated defect-rich MoS2 ultrathin nanosheets on the surfaces of CdS with irregular fissures.	Oxygen	125-131	CDP-diacylglycerol synthase 1	Homo sapiens	202-205
28686419-2	2017	Recent developments in the understanding of the mechanism of electrocatalytic O2 reduction by iron porphyrin complexes in situ using surface enhanced resonance Raman spectroscopy coupled to rotating disc electrochemistry (SERRS-RDE) in conjunction with H/D isotope effects on electrocatalytic current reveals that the rate of O2 reduction, ~104 to 105 M-1 s-1 for simple iron porphyrins, is limited by the rate of O-O bond cleavage of an intermediate ferric peroxide species (FeIII-OOH).	Oxygen	78-80	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	222-227
28720899-7	2017	The p32 +/- mice show increased oxygen consumption and heat production, indicating that they expend more energy.	Oxygen	32-38	complement component 1, q subcomponent binding protein	Mus musculus	4-7
28717127-0	2017	Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans.	Oxygen	60-66	uncoupling protein 1	Homo sapiens	34-38
28284840-4	2017	In cultured tumor cells, HIF-2alpha is stabilized at physiological oxygen concentrations followed by induced expression of classical hypoxia-driven genes, resulting in a pseudohypoxic phenotype.	Oxygen	67-73	endothelial PAS domain protein 1	Homo sapiens	25-35
28613810-2	2017	Herein, a MOF-derived phosphorization approach was developed to produce Ni2P-CoP bimetallic phosphides as bifunctional electrocatalysts for both hydrogen and oxygen evolution reactions (HER and OER).	Oxygen	158-164	caspase recruitment domain family member 16	Homo sapiens	77-80
28445841-1	2017	Rat liver mitochondria (1.5-2.1mg protein mL-1) supplemented with either 25 and 100muM Cu2+ or 100 and 500muM Fe3+ show inhibition of active respiration (O2 consumption in state 3) and increased phospholipid peroxidation .	Oxygen	154-156	L1 cell adhesion molecule	Mus musculus	42-46
28363495-1	2017	Interactions between cardiac myoglobin (Mb), nitrite, and nitric oxide (NO) are vital in regulating O2 storage, transport, and NO homeostasis.	Oxygen	100-102	myoglobin	Homo sapiens	29-38
28557414-3	2017	Herein, we report that the use of a 2 wt % N,N-dimethyltrifluoroacetamide (DMTFA) additive in a dimethyl sulfoxide (DMSO) electrolyte with a LiF layer on the Li anode allows for good cycling performance in Li-O2 batteries.	Oxygen	209-211	LIF interleukin 6 family cytokine	Homo sapiens	141-144
28642579-7	2017	Finally, we observed a decreased beta-adrenergically induced oxygen consumption in Hif-1alpha knockdown adipocytes cultured in medium with glucose as the only exogenously added fuel.	Oxygen	61-67	hypoxia inducible factor 1, alpha subunit	Mus musculus	83-93
29057303-2	2017	We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B.	Oxygen	34-40	ribonucleotide reductase regulatory subunit M2	Homo sapiens	211-215
29057303-2	2017	We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B.	Oxygen	158-164	ribonucleotide reductase regulatory subunit M2	Homo sapiens	211-215
28617444-8	2017	Under hypoxic conditions (0.5% O2, 48 h) HO-1 was induced in astrocytes and Abeta(1-42) toxicity was significantly reduced, an effect which was reversed by the specific HO-1 inhibitor, QC-15.	Oxygen	31-33	heme oxygenase 1	Homo sapiens	41-45
28617444-8	2017	Under hypoxic conditions (0.5% O2, 48 h) HO-1 was induced in astrocytes and Abeta(1-42) toxicity was significantly reduced, an effect which was reversed by the specific HO-1 inhibitor, QC-15.	Oxygen	31-33	heme oxygenase 1	Homo sapiens	169-173
28561822-9	2017	Interestingly, the oxygen atom transfer reaction from DMSO to PPh3 starting from compound 2 was found to be more efficient under the given conditions than when the reduced catalyst 1 was employed as initial species.	Oxygen	19-25	protein phosphatase 4 catalytic subunit	Homo sapiens	62-66
28442570-4	2017	CblC from Caenorhabditis elegans (ceCblC) also exhibits a robust thiol oxidase activity, converting reduced GSH to oxidized GSSG with concomitant scrubbing of ambient dissolved O2 The mechanism of thiol oxidation catalyzed by ceCblC is not known.	Oxygen	177-179	Cbl proto-oncogene C	Homo sapiens	0-4
28416613-8	2017	These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.	Oxygen	151-157	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	81-86
28341633-9	2017	PHD2 requires both oxygen and iron as cofactors for the hydroxylation of HIF-1alpha, marking it for ubiquination via VHL and subsequent destruction by the proteasome complex.	Oxygen	19-25	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
28341633-9	2017	PHD2 requires both oxygen and iron as cofactors for the hydroxylation of HIF-1alpha, marking it for ubiquination via VHL and subsequent destruction by the proteasome complex.	Oxygen	19-25	hypoxia inducible factor 1, alpha subunit	Mus musculus	73-83
28615394-5	2017	Answer Hyperbaric oxygen therapy provides a higher concentration of oxygen delivered in a chamber or tube containing higher than sea level atmospheric pressure.	Oxygen	18-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	129-132
28615394-5	2017	Answer Hyperbaric oxygen therapy provides a higher concentration of oxygen delivered in a chamber or tube containing higher than sea level atmospheric pressure.	Oxygen	68-74	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	129-132
27600268-9	2017	Thus, we discovered a novel biological pathway of soluble biglycan inducing HIF-2alpha protein stabilization and Epo production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.	Oxygen	145-151	endothelial PAS domain protein 1	Mus musculus	76-86
28558019-7	2017	DEK overexpression also increased the maximum rate of oxygen consumption and therefore increased the potential for oxidative phosphorylation (OxPhos).	Oxygen	54-60	DEK proto-oncogene	Homo sapiens	0-3
28542499-6	2017	Furthermore increased oxygen consumption and CO2 production, 38% lower glucose and 69% lower insulin levels and better insulin sensitivity were observed in ATP10D transgenic mice.	Oxygen	22-28	ATPase, class V, type 10D	Mus musculus	156-162
28273349-5	2017	A hypoxia reduction factor (HRF) is used to quantify reductions in radiosensitivity parameters alphaA and betaA as cellular oxygen concentration decreases.	Oxygen	124-130	tumor protein, translationally-controlled 1	Homo sapiens	28-31
28186467-7	2017	Controlling MSC growth conditions with oxygen tension, growth factor composition, and mechanical properties may serve to directly influence paracrine activity.	Oxygen	39-45	musculin	Homo sapiens	12-15
28201809-0	2017	Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal beta-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.	Oxygen	65-71	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	34-40
28416140-3	2017	However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia.	Oxygen	9-15	nuclear receptor subfamily 2 group E member 3	Homo sapiens	55-58
28416140-3	2017	However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia.	Oxygen	9-15	ribonucleotide reductase regulatory subunit M2	Homo sapiens	65-69
28191958-8	2017	The reduced cofactors of the DAAO subunits were reoxidized by the evolved molecular oxygen around.	Oxygen	84-90	D-amino acid oxidase	Homo sapiens	29-33
28184000-9	2017	Treatment with recombinant ANGPTL6 protein increased oxygen consumption and Pparalpha expression through the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in cultured adipocytes.	Oxygen	53-59	angiopoietin-like 6	Mus musculus	27-34
28251649-6	2017	The reduction to 1% in oxygen supply (2 h) to cells decreased the levels of released PNP, leading to an increased presence of extracellular nucleosides and to a reduced formation of xanthine and uric acid.	Oxygen	23-29	purine nucleoside phosphorylase	Rattus norvegicus	85-88
28259998-2	2017	Considering the relative low oxygen microenvironment in stem cell niche, we hypothesized that an enhanced PKM2 expression associates with the biological properties of cancer stem cells.	Oxygen	29-35	pyruvate kinase M1/2	Homo sapiens	106-110
28288167-7	2017	EPO-injected mice also showed increased oxygen consumption, indicative of metabolic rate, and skin temperature around iBAT tissue masses.	Oxygen	40-46	erythropoietin	Mus musculus	0-3
28159615-7	2017	On the other hand, the generated H2O2 of ELP-DAAO was decomposed by the MnO2 nanorods, and the evolved oxygen oxidized the reduced cofactors of ELP-DAAO.	Oxygen	103-109	nuclear receptor subfamily 5 group A member 1	Homo sapiens	41-44
28159615-7	2017	On the other hand, the generated H2O2 of ELP-DAAO was decomposed by the MnO2 nanorods, and the evolved oxygen oxidized the reduced cofactors of ELP-DAAO.	Oxygen	103-109	D-amino acid oxidase	Homo sapiens	45-49
28159615-7	2017	On the other hand, the generated H2O2 of ELP-DAAO was decomposed by the MnO2 nanorods, and the evolved oxygen oxidized the reduced cofactors of ELP-DAAO.	Oxygen	103-109	nuclear receptor subfamily 5 group A member 1	Homo sapiens	144-147
28159615-7	2017	On the other hand, the generated H2O2 of ELP-DAAO was decomposed by the MnO2 nanorods, and the evolved oxygen oxidized the reduced cofactors of ELP-DAAO.	Oxygen	103-109	D-amino acid oxidase	Homo sapiens	148-152
28207244-7	2017	Complex 3 functions as an oxygen atom transfer (OAT) reagent capable of oxidizing phosphorus(III) compounds (P(OMe)3, PPh3) and SMe2 at ambient temperature to result in the corresponding organic oxide with regeneration of dimer 1.	Oxygen	26-32	protein phosphatase 4 catalytic subunit	Homo sapiens	118-122
28244872-1	2017	A LOV (Light, Oxygen, or Voltage) domain containing blue-light photoreceptor ZEITLUPE (ZTL) directs circadian timing by degrading clock proteins in plants.	Oxygen	14-20	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	77-85
28244872-1	2017	A LOV (Light, Oxygen, or Voltage) domain containing blue-light photoreceptor ZEITLUPE (ZTL) directs circadian timing by degrading clock proteins in plants.	Oxygen	14-20	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	87-90
28231837-8	2017	RESULTS: PBMCs from nAMD patients secreted higher levels of IL-8, CCL2 and VEGF, especially following LPS and 1% oxygen stimulation, than those from controls.	Oxygen	113-119	C-C motif chemokine ligand 2	Homo sapiens	66-70
28115238-0	2017	NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway.	Oxygen	21-27	heme oxygenase 1	Homo sapiens	111-115
28249151-4	2017	We used quantitative RT-PCR to measure BRCA1 and NBR2 transcript levels in 0% and 1% oxygen in MCF-7 breast cancer cells and found that NBR2 transcript levels increased as a function of time under hypoxic conditions, whereas BRCA1 mRNA levels were repressed.	Oxygen	85-91	neighbor of BRCA1 lncRNA 2	Homo sapiens	136-140
28161055-11	2017	In isolated primary trophoblasts, HSP70 and HO-1 were upregulated by increasing oxygen tension, but not by hyperglycemia or TNF-alpha.	Oxygen	80-86	heme oxygenase 1	Homo sapiens	44-48
27639592-2	2017	Receptor-interacting protein 140 (RIP140) is an important transcriptional cofactor for maintaining energy balance in high-oxygen consumption tissues.	Oxygen	122-128	nuclear receptor interacting protein 1	Rattus norvegicus	0-32
27639592-2	2017	Receptor-interacting protein 140 (RIP140) is an important transcriptional cofactor for maintaining energy balance in high-oxygen consumption tissues.	Oxygen	122-128	nuclear receptor interacting protein 1	Rattus norvegicus	34-40
28395335-4	2017	Interestingly, we established that Stro1+/CD44+ MSC respond efficiently to physiological cues when they were treated in vitro under different dose-dependent pregnant rat serum.Previous studies reveal strong regulatory links between O2 availability and stem cell function.	Oxygen	232-234	CD44 molecule (Indian blood group)	Rattus norvegicus	42-46
28395335-6	2017	We also detected a total of 37 upregulated and 44 downregulated hypoxia-related genes, which were differentially expressed in Stro1+/CD44+ MSC, providing an alternative approach to infer into complex molecular mechanisms such as energy metabolism, inflammatory response, uterine expansion, and/or remodeling.Since these cells preferentially grow under low oxygen conditions, we propose that the increase of the rat uterus during pregnancy involves myometrial oxygen consumption, thereby enhancing MSC proliferation.	Oxygen	356-362	CD44 molecule (Indian blood group)	Rattus norvegicus	133-137
28395335-6	2017	We also detected a total of 37 upregulated and 44 downregulated hypoxia-related genes, which were differentially expressed in Stro1+/CD44+ MSC, providing an alternative approach to infer into complex molecular mechanisms such as energy metabolism, inflammatory response, uterine expansion, and/or remodeling.Since these cells preferentially grow under low oxygen conditions, we propose that the increase of the rat uterus during pregnancy involves myometrial oxygen consumption, thereby enhancing MSC proliferation.	Oxygen	459-465	CD44 molecule (Indian blood group)	Rattus norvegicus	133-137
28869464-3	2017	Oxygen deprivation (OD) resulted in tau dephosphorylation at several AD-related residues and activation of GSK3beta and phosphatase PP2A.	Oxygen	0-6	glycogen synthase kinase 3 beta	Mus musculus	107-115
27913654-3	2017	Our previous work has shown that through decreased activation of the cytoskeletal protein paxillin, growth factor-induced ischemic retinopathy in the murine oxygen-induced retinopathy model could be inhibited.	Oxygen	157-163	paxillin	Homo sapiens	90-98
27818353-0	2017	Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons.	Oxygen	84-90	cathepsin L	Rattus norvegicus	14-25
27818353-0	2017	Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons.	Oxygen	84-90	carbonic anhydrase 1	Rattus norvegicus	134-137
27818353-1	2017	Oxygen and glucose deprivation (OGD) elicits a rapid and irreversible depolarization with a latency of ~5min in intracellular recordings of hippocampal CA1 neurons in rat slice preparations.	Oxygen	0-6	carbonic anhydrase 1	Rattus norvegicus	152-155
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	Oxygen	33-35	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	73-76
29387292-0	2017	Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.	Oxygen	100-106	nitric oxide synthase 3, endothelial cell	Mus musculus	121-125
29387292-8	2017	Conversely, mild oxygen/hyperoxia stimulates kallistatin, eNOS, and hypoxia-inducible factor-1 (HIF-1) expression in endothelial cells and in the kidney of normal mice.	Oxygen	17-23	nitric oxide synthase 3, endothelial cell	Mus musculus	58-62
29387292-9	2017	Likewise, kallistatin stimulates eNOS and HIF-1, and kallistatin antisense RNA abolishes oxygen-induced eNOS and HIF-1 expression, indicating a role of kallistatin in mediating mild oxygen"s stimulation on antioxidant genes.	Oxygen	89-95	nitric oxide synthase 3, endothelial cell	Mus musculus	104-108
28032866-3	2016	Knockdown of E2-25K expression protects against oxygen/glucose deprivation and reoxygenation (OGD/R)-induced neuronal cell death, whereas ectopic expression of E2-25K stimulates it.	Oxygen	48-54	ubiquitin-conjugating enzyme E2K	Mus musculus	13-19
28002489-0	2016	Correction: CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.	Oxygen	90-96	CD34 antigen	Mus musculus	12-16
27792302-0	2016	Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen.	Oxygen	131-137	STEAP family member 1	Homo sapiens	0-50
27792302-0	2016	Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen.	Oxygen	131-137	STEAP family member 1	Homo sapiens	52-58
27792302-7	2016	Ferrous STEAP1 also reacts readily with O2 through an outer sphere redox mechanism.	Oxygen	40-42	STEAP family member 1	Homo sapiens	8-14
27865689-1	2016	INTRODUCTION: In the present study, we examined retinal vascular oxygen saturation in patients with retinal vein occlusion (RVO), high blood pressure (HBP) and dyslipidemia, before and during intravitreal vascular endothelial growth factor (VEGF) injection (ranibizumab).	Oxygen	65-71	high density lipoprotein binding protein	Homo sapiens	130-149
27865689-9	2016	CONCLUSION: In this study, retinal venous oxygen saturation in patients with RVO, HBP and dyslipidemia was partially normalized during intravitreal ranibizumab treatment.	Oxygen	42-48	high density lipoprotein binding protein	Homo sapiens	82-85
27871461-12	2016	NFAT1 and NFAT3 mRNA expression were significantly increased under hypoxia (1% O2).	Oxygen	79-81	nuclear factor of activated T cells 2	Homo sapiens	0-5
27808302-4	2016	Suppression of the oxygen reactivity at N593C-POx variant is a prerequisite for utilizing POx in electrochemical applications for glucose sensing.	Oxygen	19-25	proline dehydrogenase 1	Homo sapiens	46-49
27808302-4	2016	Suppression of the oxygen reactivity at N593C-POx variant is a prerequisite for utilizing POx in electrochemical applications for glucose sensing.	Oxygen	19-25	proline dehydrogenase 1	Homo sapiens	90-93
27793037-5	2016	We demonstrate that c-Myc mRNA and protein levels in colon cancer cells are induced within 2 h of hypoxic stress (1% O2) but are then significantly downregulated when exposed to prolonged hypoxia.	Oxygen	117-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	20-25
27793037-6	2016	In chronic hypoxia (over 8 h at 1% O2), HIF-2alpha but not HIF-1alpha gradually accumulated in colon cancer cells.	Oxygen	35-37	endothelial PAS domain protein 1	Homo sapiens	40-50
27683416-6	2016	We furthermore determined that Epo transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.	Oxygen	123-129	erythropoietin	Mus musculus	31-34
27758871-1	2016	Previous research has indicated that long-chain fatty acids can bind myoglobin (Mb) in an oxygen-dependent manner.	Oxygen	90-96	myoglobin	Homo sapiens	69-78
27758871-1	2016	Previous research has indicated that long-chain fatty acids can bind myoglobin (Mb) in an oxygen-dependent manner.	Oxygen	90-96	myoglobin	Homo sapiens	80-82
27791208-1	2016	In this present study, a series of cobalt porphyrin-based conjugated mesoporous polymers (CoP-nph-CMP, n = 2, 3, 4) were fabricated as catalyst precursors to generate bifunctional catalysts via pyrolysis (CoP-nph-CMP-800, n = 2, 3, 4) for both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER).	Oxygen	248-254	caspase recruitment domain family member 16	Homo sapiens	90-93
27726305-8	2016	Moreover, the administration of NAC, an active oxygen scavenger, markedly reduces solanine-induced cell death.	Oxygen	47-53	synuclein alpha	Homo sapiens	32-35
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	255-265
27562812-4	2016	ARS degradation was optimal operation at initial pH 3 with O2.The experimental results showed that the COD removal efficiency was better, reaching to about 90 % when applying the novel electrode system.	Oxygen	59-61	secreted LY6/PLAUR domain containing 1	Homo sapiens	0-3
27786263-0	2016	Irminger Sea deep convection injects oxygen and anthropogenic carbon to the ocean interior.	Oxygen	37-43	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
27739509-9	2016	5% O2 significantly increased the proliferation rate, migration ability, expression of stem cell markers (CXCR4 and G-CSFR), and expression of SOX2, VEGF, NGF, and BDNF genes of DPSCs.	Oxygen	3-5	colony stimulating factor 3 receptor	Homo sapiens	116-122
27782425-7	2016	A detailed comparison of the present and previous results on O2-CF4 and O2-CCl4 systems pinpointed striking differences in the behavior of hydrogen and oxygen molecules when they interact with the same partner, mainly due to the selectivity of the charge transfer component.	Oxygen	152-158	C-C motif chemokine ligand 4	Homo sapiens	75-79
27449900-6	2016	Here, we aimed to investigate the role of miR-146a and its possible target genes in human SK-N-SH cells subjected to 16h of oxygen-glucose deprivation and 12h of reperfusion (OGD/R) injury.	Oxygen	124-130	microRNA 146a	Homo sapiens	42-50
27656164-6	2016	In all three "single-quinone" E. coli strains transitions in the activity of ArcB are observed, as evidenced by changes in the level of phosphorylation of the response regulator ArcA, upon depletion/readmission of oxygen.	Oxygen	214-220	hypothetical protein	Escherichia coli	77-81
27417579-9	2016	Soluble epoxide hydrolase inhibition, which blocks breakdown and inactivation of CYP2C omega-3 LCPUFA-derived active metabolites, increased oxygen-induced retinopathy and CNV in vivo.	Oxygen	140-146	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	81-86
27447861-3	2016	However, to survive and evolve in a hypoxic tumor milieu, cancer cells must revise MYC-driven metabolism because the mitochondrial respiratory chain provides free electrons to generate oxygen free radicals with inefficient production of ATP due to oxygen depletion.	Oxygen	185-191	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	83-86
27244243-7	2016	The resulting O species, mainly formed O(2-) dissolved in the molten MgCl2, was removed from the molten salt by reacting with the C anode to form CO (or CO2) gas.	Oxygen	39-44	complement C2	Homo sapiens	153-156
27132805-9	2016	Furthermore, suppressed mitochondrial DNA content and decreased oxygen consumption rate were also detected upon Set7/9 knockdown.	Oxygen	64-70	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	112-118
26988816-3	2016	The purpose of this study was to investigate whether magnetization-prepared FLAIR MR imaging can reduce oxygen-induced CSF hyperintensity and improve image quality compared with conventional (non-magnetization-prepared) FLAIR MR imaging.	Oxygen	104-110	colony stimulating factor 2	Homo sapiens	119-122
26988816-13	2016	CONCLUSIONS: Magnetization-prepared 3D-FLAIR MR imaging can significantly reduce oxygen-induced CSF artifacts and increase the tissue contrast-to-noise ratio beyond the levels achieved with conventional non-magnetization-prepared 3D-FLAIR MR imaging.	Oxygen	81-87	colony stimulating factor 2	Homo sapiens	96-99
26928132-7	2016	Inclusion of enzymatically active glutaredoxin-2 (Grx2) in reaction mixtures reversed the GSH-mediated amplification of O2( -)/H2O2 formation.	Oxygen	120-122	glutaredoxin 2 (thioltransferase)	Mus musculus	34-48
26928132-7	2016	Inclusion of enzymatically active glutaredoxin-2 (Grx2) in reaction mixtures reversed the GSH-mediated amplification of O2( -)/H2O2 formation.	Oxygen	120-122	glutaredoxin 2 (thioltransferase)	Mus musculus	50-54
27417539-2	2016	Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunteers at 5,260 m altitude on day 1 and continue increasing to 16 days with concurrently elevated erythrocyte sphingonisne kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.	Oxygen	316-322	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
27417539-2	2016	Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunteers at 5,260 m altitude on day 1 and continue increasing to 16 days with concurrently elevated erythrocyte sphingonisne kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.	Oxygen	324-326	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
27417539-3	2016	Mouse genetic studies show that elevated erythrocyte Sphk1-induced S1P protects against tissue hypoxia by inducing O2 release.	Oxygen	115-117	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
27417539-4	2016	Mechanistically, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the release of membrane-bound glycolytic enzymes to the cytosol, induces glycolysis and thus the production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific glycolytic intermediate, which facilitates O2 release.	Oxygen	322-324	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
27417539-5	2016	Altogether, we reveal S1P as an intracellular hypoxia-responsive biolipid promoting erythrocyte glycolysis, O2 delivery and thus new therapeutic opportunities to counteract tissue hypoxia.	Oxygen	108-110	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
27867469-0	2016	Hyperbaric oxygen increases tissue-plasminogen activator-induced thrombolysis in vitro, and reduces ischemic brain damage and edema in rats subjected to thromboembolic brain ischemia.	Oxygen	11-17	plasminogen activator, tissue type	Rattus norvegicus	28-56
27095058-7	2016	More recently, TERT has been associated with the decrease in reactive oxygen species and DNA protection in mitochondria of neurons.	Oxygen	70-76	telomerase reverse transcriptase	Homo sapiens	15-19
27221116-7	2016	Furthermore, respiration rates of intact cells deficient for Nr4a1 or Nr4a3 in the presence of 16 mM glucose resulted in decreased glucose mediated oxygen consumption.	Oxygen	148-154	nuclear receptor subfamily 4, group A, member 1	Mus musculus	61-66
26997358-0	2016	Low oxygen tension favored expansion and hematopoietic reconstitution of CD34(+) CD38(-) cells expanded from human cord blood-derived CD34(+) Cells.	Oxygen	4-10	CD38 molecule	Homo sapiens	81-85
26997358-6	2016	It was found that low oxygen tension favored expansion of CD34(+) CD38(-) cells.	Oxygen	22-28	CD38 molecule	Homo sapiens	66-70
26997358-8	2016	Finally, the genetic profiling of CD34(+) CD38(-) cells cultured under low oxygen tension was more akin to freshly isolated cells.	Oxygen	75-81	CD38 molecule	Homo sapiens	42-46
27289126-4	2016	In addition, the hemoconcentration that typically follows SGLT2 inhibition enhances oxygen release to the tissues, thereby establishing a powerful synergy with the metabolic substrate shift.	Oxygen	84-90	solute carrier family 5 member 2	Homo sapiens	58-63
27121290-3	2016	It was therefore examined whether glucose and oxygen influenced the response of glioma cells to EGFR inhibition.	Oxygen	46-52	epidermal growth factor	Homo sapiens	96-100
27121290-4	2016	Decreased levels of glucose and oxygen led to resistance against the EGFR inhibitor PD153035, whereas high glucose amounts and normoxia sensitised glioma cells towards the inhibitor.	Oxygen	32-38	epidermal growth factor	Homo sapiens	69-73
26964921-11	2016	Sodium cholate (NaC) was found to show strong interaction towards quercitin (QT) due to more electron density on oxygen atom of carboxylate ion.	Oxygen	113-119	synuclein alpha	Homo sapiens	16-19
27362802-5	2016	ARNT is considered to be unaffected by hypoxia but certain cell lines, including Hep3B cells, are capable to elevate this transcription factor in response to oxygen deprivation, which implies an advantage.	Oxygen	158-164	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
27352134-0	2016	CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.	Oxygen	78-84	CD34 antigen	Mus musculus	0-4
27352134-6	2016	In oxygen-induced retinopathy, Cd34-/- mice showed normal intra-retinal regenerative angiogenesis but the number of pathological epi-retinal neovascular tufts were reduced.	Oxygen	3-9	CD34 antigen	Mus musculus	31-35
27243276-1	2016	A unified kinetic theory for both initiation and autoxidation reactions of Et3B and O2 is put forth, and then divided into low-oxygen and high-oxygen experimental regimes for application of Et3B/O2 as an initiating system.	Oxygen	127-133	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	75-86
28702623-2	2017	The oxygen storage properties during structural transformation between stoichiometric Hex0 and oxygen-loaded Hex1 phases, transition temperatures and kinetics of the oxygen incorporation and release are reported for materials prepared by the solid-state synthesis and high-impact mechanical milling.	Oxygen	95-101	exonuclease 1	Homo sapiens	109-113
28702623-2	2017	The oxygen storage properties during structural transformation between stoichiometric Hex0 and oxygen-loaded Hex1 phases, transition temperatures and kinetics of the oxygen incorporation and release are reported for materials prepared by the solid-state synthesis and high-impact mechanical milling.	Oxygen	95-101	exonuclease 1	Homo sapiens	109-113
28746349-3	2017	We have previously reported altered erythrocyte adenine nucleotide levels corresponding to altered oxygen saturation in mice deficient in both CD73 and AMPD3.	Oxygen	99-105	5' nucleotidase, ecto	Mus musculus	143-147
28467784-6	2017	In vitro, we observed that IDH1MUT cancer cells have a higher basal respiration compared to IDH1WT cancer cells and inhibition of the IDH1MUT shifts the metabolism by decreasing oxygen consumption and increasing glycolysis.	Oxygen	178-184	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-31
28728562-8	2017	The transcription levels of MnSOD, PRDX5, VEGF and GLUT-3 also significantly increased in 3% O2 compared with 20% O2 (P &lt; 0.05).	Oxygen	93-95	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	51-57
29050245-6	2017	Oxygen deficiency or reactive oxygen species (ROS) disrupted the interaction between IL-32beta and VHL, leading to the accumulation of the cytokine.	Oxygen	0-6	interleukin 32	Homo sapiens	85-94
28699638-4	2017	Selective inhibition of BCAT1 activity results in decreased oxygen consumption and glycolysis.	Oxygen	60-66	branched chain amino acid transaminase 1	Homo sapiens	24-29
28514318-3	2017	Although NIRS-measured cerebral tissue O2 saturation (ScO2) correlates with arterial oxygen saturation (SaO2), jugular bulb O2 saturation (SjbO2), and Hb, little data exist on the interplay between these factors and cerebral O2 extraction (COE).	Oxygen	39-41	synthesis of cytochrome C oxidase 2	Homo sapiens	54-58
28514318-3	2017	Although NIRS-measured cerebral tissue O2 saturation (ScO2) correlates with arterial oxygen saturation (SaO2), jugular bulb O2 saturation (SjbO2), and Hb, little data exist on the interplay between these factors and cerebral O2 extraction (COE).	Oxygen	85-91	synthesis of cytochrome C oxidase 2	Homo sapiens	54-58
28400392-4	2017	Immunohistochemical staining for RUNX1 showed reactivity in vessels of patient-derived FVMs and angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.	Oxygen	140-146	RUNX family transcription factor 1	Homo sapiens	33-38
28400392-5	2017	Inhibition of RUNX1 activity with the Ro5-3335 small molecule resulted in a significant reduction of neovascular tufts in oxygen-induced retinopathy, supporting the feasibility of targeting RUNX1 in aberrant retinal angiogenesis.	Oxygen	122-128	RUNX family transcription factor 1	Homo sapiens	14-19
28635661-4	2017	Under hypoxia (2% O2), the expression of GRP78 was significantly increased via hypoxia-inducible factor (HIF)-1alpha.	Oxygen	18-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	79-116
28461337-0	2017	The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone.	Oxygen	111-117	CDGSH iron sulfur domain 1	Homo sapiens	41-49
28461337-5	2017	Here we report that the reduced mitoNEET [2Fe-2S] clusters can be readily oxidized by oxygen.	Oxygen	86-92	CDGSH iron sulfur domain 1	Homo sapiens	32-40
27982759-0	2017	MR Imaging-derived Oxygen Metabolism and Neovascularization Characterization for Grading and IDH Gene Mutation Detection of Gliomas.	Oxygen	19-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	93-96
27982759-11	2017	Conclusion MR imaging-derived oxygen metabolism and neovascularization characterization may be useful for grading and IDH mutation detection of gliomas and requires only 7 minutes of extra imaging time.	Oxygen	30-36	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	118-121
28690378-7	2017	In Lig No#5, we decreased the hydrophobicity by adding oxygen in the hydrophobic tail of the molecule at positions C5 and C10.	Oxygen	55-61	ubiquitin conjugating enzyme E2 K	Homo sapiens	3-6
28556799-6	2017	Hepatic mitochondrial oxygen consumption was reduced in IR-IRS1dh animals at 12 months of age.	Oxygen	22-28	insulin receptor substrate 1	Mus musculus	59-63
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Oxygen	109-111	caspase recruitment domain family member 16	Homo sapiens	7-10
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Oxygen	109-111	caspase recruitment domain family member 16	Homo sapiens	17-20
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Oxygen	211-213	caspase recruitment domain family member 16	Homo sapiens	7-10
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Oxygen	211-213	caspase recruitment domain family member 16	Homo sapiens	17-20
28126468-7	2017	In vitro studies show that low oxygen increases hepatocellular ATX expression and transcriptome analysis showed a positive correlation between ATX mRNA levels and hypoxia gene score in HCC tumour tissue associated with HCV and other aetiologies.	Oxygen	31-37	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	63-66
28323063-5	2017	In wild-type cells, Flo1p-dependent flocculation occurs under oxygen-limited growth, which reduces unsaturated lipid synthesis and thus serves as the environmental trigger for flocculation.	Oxygen	62-68	flocculin FLO1	Saccharomyces cerevisiae S288C	20-25
28473751-3	2017	Although low partial pressure of blood oxygen directly activates TRPV4, humoral factors could also be involved.	Oxygen	39-45	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	65-70
28355055-6	2017	Interestingly, in terms of catalysis NiPS3, CoPS3, and BiPS4 show the highest efficiency for hydrogen evolution reaction (HER), while for the oxygen evolution reaction (OER) the highest performance is observed for CoPS3.	Oxygen	142-148	COP9 signalosome subunit 3	Homo sapiens	214-219
28228417-0	2017	Oxygen-sensitive regulation and neuroprotective effects of growth hormone-dependent growth factors during early postnatal development.	Oxygen	0-6	growth hormone	Mus musculus	59-73
28266966-3	2017	PHD1 to PHD3 are molecular oxygen sensors and increasingly considered as putative therapeutic targets.	Oxygen	27-33	egl-9 family hypoxia-inducible factor 3	Mus musculus	8-12
28097375-4	2017	FGF11 is an intracellular FGF that was induced both by hypoxia (2% O2, p &lt; 0.01) and by inhibition of the HIF-regulating prolyl hydroxylase enzymes (CoCl2, p &lt; 0.001) in osteoclasts.	Oxygen	67-69	fibroblast growth factor 11	Homo sapiens	0-5
28097375-4	2017	FGF11 is an intracellular FGF that was induced both by hypoxia (2% O2, p &lt; 0.01) and by inhibition of the HIF-regulating prolyl hydroxylase enzymes (CoCl2, p &lt; 0.001) in osteoclasts.	Oxygen	67-69	fibroblast growth factor 11	Homo sapiens	0-3
27835780-8	2017	Remarkably, the expression level of hypoxia-inducible factor (HIF)-2alpha (but not HIF-1alpha) was higher in both 10%O2 and 30%O2 with respect to 21%O2 INNOVATION: Comparing the in vivo effects driven by mild hypoxia with those driven by mild hyperoxia helps addressing whether clinically relevant situations of O2 excess and scarcity are toxic for the organism.	Oxygen	117-119	endothelial PAS domain protein 1	Mus musculus	36-73
27835780-8	2017	Remarkably, the expression level of hypoxia-inducible factor (HIF)-2alpha (but not HIF-1alpha) was higher in both 10%O2 and 30%O2 with respect to 21%O2 INNOVATION: Comparing the in vivo effects driven by mild hypoxia with those driven by mild hyperoxia helps addressing whether clinically relevant situations of O2 excess and scarcity are toxic for the organism.	Oxygen	127-129	endothelial PAS domain protein 1	Mus musculus	36-73
27835780-8	2017	Remarkably, the expression level of hypoxia-inducible factor (HIF)-2alpha (but not HIF-1alpha) was higher in both 10%O2 and 30%O2 with respect to 21%O2 INNOVATION: Comparing the in vivo effects driven by mild hypoxia with those driven by mild hyperoxia helps addressing whether clinically relevant situations of O2 excess and scarcity are toxic for the organism.	Oxygen	127-129	endothelial PAS domain protein 1	Mus musculus	36-73
27835780-8	2017	Remarkably, the expression level of hypoxia-inducible factor (HIF)-2alpha (but not HIF-1alpha) was higher in both 10%O2 and 30%O2 with respect to 21%O2 INNOVATION: Comparing the in vivo effects driven by mild hypoxia with those driven by mild hyperoxia helps addressing whether clinically relevant situations of O2 excess and scarcity are toxic for the organism.	Oxygen	127-129	endothelial PAS domain protein 1	Mus musculus	36-73
28126520-5	2017	The physiologically occurring oxygen gradient was considered to be crucial for the appearance of zonation; however, a number of reports during the last decade indicating that beta-catenin signaling, and the hedgehog (Hh) pathway contribute to metabolic zonation may have shifted this view.	Oxygen	30-36	catenin beta 1	Homo sapiens	175-187
28202541-1	2017	The Mga2 and Sre1 transcription factors regulate oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 transcription factors.	Oxygen	49-55	sterol regulatory element binding transcription factor 1	Homo sapiens	171-222
28154187-11	2017	Expression of a double acetylation mimic of MPC2 (K19Q/K26Q) in H9c2 cells was sufficient to decrease the maximal cellular oxygen consumption rate.	Oxygen	123-129	mitochondrial pyruvate carrier 2	Rattus norvegicus	44-48
28302994-9	2017	The expression levels of stem cell markers, including NS, Nanog, Oct-4, and SSEA-4, were highest in 0.5% O2 culture.	Oxygen	105-107	POU class 5 homeobox 1	Homo sapiens	65-70
27939695-8	2017	The inhibition of mitochondrial oxygen consumption by AG311 was found to reduce HIF-1alpha stabilization by increasing oxygen tension in hypoxic conditions.	Oxygen	32-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	80-90
27939695-8	2017	The inhibition of mitochondrial oxygen consumption by AG311 was found to reduce HIF-1alpha stabilization by increasing oxygen tension in hypoxic conditions.	Oxygen	119-125	hypoxia inducible factor 1, alpha subunit	Mus musculus	80-90
27778229-5	2017	They were then transfected with mRNA ETV2 and incubated in culture medium under hypoxia (5% oxygen) for 14 d. Phenotype analysis of transfected cells confirmed that single-factor ETV2 transfection successfully reprogrammed dermal fibroblasts into functional EPCs.	Oxygen	92-98	ETS variant transcription factor 2	Homo sapiens	179-183
27157507-5	2017	Oxygen cost of running at different velocities was 192.2 +- 14.7 ml  kg-1  km-1 at 12 km  h-1 and 184.8 +- 9.9 ml  kg-1  km-1 at 20 km  h-1, which corresponded to a caloric cost of running of 0.94 +- 0.07 kcal  kg-1 km-1 and 0.93 +- 0.07 kcal  kg-1  km-1.	Oxygen	0-6	H1.5 linker histone, cluster member	Homo sapiens	90-93
27157507-5	2017	Oxygen cost of running at different velocities was 192.2 +- 14.7 ml  kg-1  km-1 at 12 km  h-1 and 184.8 +- 9.9 ml  kg-1  km-1 at 20 km  h-1, which corresponded to a caloric cost of running of 0.94 +- 0.07 kcal  kg-1 km-1 and 0.93 +- 0.07 kcal  kg-1  km-1.	Oxygen	0-6	H1.5 linker histone, cluster member	Homo sapiens	136-139
27475952-1	2017	Hyperoxia results from the inhalation of mixtures of gas containing higher partial pressures of oxygen (O2) than normal air at sea level.	Oxygen	96-102	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
27475952-1	2017	Hyperoxia results from the inhalation of mixtures of gas containing higher partial pressures of oxygen (O2) than normal air at sea level.	Oxygen	104-106	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
27980124-5	2017	Based on a mathematical analysis of the relative roles of ACR and R-L shunt on O2 and CO2 levels, we predict that ventilatory modifications are much more effective for gastric CO2 supply with only modest effects on O2 delivery.	Oxygen	79-81	acrosin	Homo sapiens	58-61
27980124-7	2017	The different effects of altering ACR and R-L shunt on O2 and CO2 levels are explained by the differences in the effective blood capacitance coefficients.	Oxygen	55-57	acrosin	Homo sapiens	34-37
28507790-7	2017	These results uncover a connection between the HIF-1alpha oxygen-sensing pathway and CD69 immunobiology.	Oxygen	58-64	hypoxia inducible factor 1, alpha subunit	Mus musculus	47-57
28045078-8	2017	The amplitude of PER3 expression was positively correlated with moderate and vigorous physical activity (r = 0.582, p = 0.007) and peak oxygen uptake (r = 0.481, p = 0.032), but these correlations were not observed for NR1D1 or NR1D2.	Oxygen	136-142	period circadian regulator 3	Homo sapiens	17-21
29127682-2	2017	Because HBB protein is a critical component (along with alpha-globin, heme, and iron) of hemoglobin, the molecule essential for oxygen delivery to tissues, mutations in HBB can result in lethal diseases or diseases with multi-organ dysfunction.	Oxygen	128-134	hemoglobin subunit beta	Homo sapiens	8-11
29127682-2	2017	Because HBB protein is a critical component (along with alpha-globin, heme, and iron) of hemoglobin, the molecule essential for oxygen delivery to tissues, mutations in HBB can result in lethal diseases or diseases with multi-organ dysfunction.	Oxygen	128-134	hemoglobin subunit beta	Homo sapiens	169-172
28395329-6	2017	Using annexin-V as a marker of released MP assessed by flow cytometry and cytochrome c reduction assay to measure EC superoxide generation, we found that MP release and superoxide generation were significantly increased when cells were cultured under 2%O2, which could be significantly inhibited by 1,25(OH)2D3.	Oxygen	253-255	annexin A5	Homo sapiens	6-15
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	109-115	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	128-135
28685009-10	2017	Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.	Oxygen	197-203	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	128-135
27760758-8	2016	Moreover, systemic reduction in EPO levels by hyperbaric oxygen (HBO) used in a preclinical mouse model and in a pilot clinical trial promoted homing of transplanted UCB CD34+ HSPC to BM.	Oxygen	57-63	erythropoietin	Mus musculus	32-35
27760758-8	2016	Moreover, systemic reduction in EPO levels by hyperbaric oxygen (HBO) used in a preclinical mouse model and in a pilot clinical trial promoted homing of transplanted UCB CD34+ HSPC to BM.	Oxygen	57-63	CD34 antigen	Mus musculus	170-174
27738103-6	2016	Transgenic mice overexpressing Ldhb in muscle (muscle creatine kinase (MCK)-Ldhb) exhibited increased exercise performance and enhanced oxygen consumption during exercise.	Oxygen	136-142	lactate dehydrogenase B	Mus musculus	31-35
27738103-6	2016	Transgenic mice overexpressing Ldhb in muscle (muscle creatine kinase (MCK)-Ldhb) exhibited increased exercise performance and enhanced oxygen consumption during exercise.	Oxygen	136-142	lactate dehydrogenase B	Mus musculus	76-80
28260494-2	2016	In addition to reversible O2 binding, respiratory proteins of the globin family, hemoglobin (Hb) and myoglobin (Mb), participate in redox reactions with various metal complexes, including biologically significant ones, such as those of copper and iron.	Oxygen	26-28	myoglobin	Homo sapiens	101-110
27685324-3	2016	Enzymatic oxidation at the C-4 position was carried out anaerobically using H2O as an oxygen donor.	Oxygen	86-92	complement C4A (Rodgers blood group)	Homo sapiens	27-30
27693962-0	2016	Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning.	Oxygen	50-56	inhibin subunit beta A	Rattus norvegicus	11-20
27634387-8	2016	Oxygen consumption is elevated in S6K1-depeleted HeLa cells and FL5.12 cells.	Oxygen	0-6	ribosomal protein S6 kinase B1	Homo sapiens	34-38
27889479-5	2016	In this study, we investigated how genetic loss of IDO1 affects neovascularization in mouse models of oxygen-induced retinopathy and lung metastasis.	Oxygen	102-108	indoleamine 2,3-dioxygenase 1	Mus musculus	51-55
27840972-0	2016	Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury.	Oxygen	22-28	C-C motif chemokine ligand 2	Rattus norvegicus	49-54
27553877-0	2016	Post-traumatic administration of the p53 inactivator pifithrin-alpha oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.	Oxygen	69-75	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	37-40
27553877-4	2016	Our previous studies demonstrated that a p53 inhibitor, pifithrin-alpha oxygen analogue (PFT-alpha (O)), significantly reduced cortical cell death, which is substantial following controlled cortical impact (CCI) TBI, and improved neurological functional outcomes via anti-apoptotic mechanisms.	Oxygen	72-78	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	41-44
27655692-4	2016	Oncogenic HRas leads to suppression of the mitochondrial oxygen consumption rate (OCR), but oxygen consumption is essential for tumorigenesis.	Oxygen	57-63	HRas proto-oncogene, GTPase	Homo sapiens	10-14
27827416-3	2016	In HFD-fed mice, despite the increase in renal pimonidazole-positive areas, the expressions of the hypoxia-responsive genes such as Prolyl-hydroxylase PHD2, a dominant oxygen sensor, and VEGFA were unchanged indicating impaired hypoxic response.	Oxygen	168-174	egl-9 family hypoxia-inducible factor 1	Mus musculus	151-155
26735968-9	2016	Irisin up-regulation in cases of smoking may indicate the need for enhanced oxygen consumption to maintain energy production under conditions of hypoxia.	Oxygen	76-82	fibronectin type III domain containing 5	Homo sapiens	0-6
26753753-4	2016	RESULTS: In premature infants, ROS levels increased significantly after treatment with oxygen, in a concentration-dependent manner (p &lt; 0.05); meanwhile, p47phox translocation and expression were significantly enhanced (p &lt; 0.05) as well.	Oxygen	87-93	pleckstrin	Homo sapiens	157-160
27667724-3	2016	Using in situ environmental transmission electron microscopy techniques, we demonstrate that surface oxygen loss and structural changes in the highly overcharged NCA particles are suppressed by exposing them to an oxygen-rich environment.	Oxygen	101-107	CEA cell adhesion molecule 6	Homo sapiens	162-165
27667724-3	2016	Using in situ environmental transmission electron microscopy techniques, we demonstrate that surface oxygen loss and structural changes in the highly overcharged NCA particles are suppressed by exposing them to an oxygen-rich environment.	Oxygen	214-220	CEA cell adhesion molecule 6	Homo sapiens	162-165
27507791-2	2016	Caenorhabditis elegans fed a glucose-supplemented diet or with altered ceramide metabolism, due to a hyl-2 mutation, are sensitive to oxygen deprivation (anoxia).	Oxygen	134-140	Ceramide synthase hyl-2	Caenorhabditis elegans	101-106
27667798-4	2016	The resultant N, P, and F tri-doped graphene exhibited excellent electrocatalytic activities for the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER).	Oxygen	101-107	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
27667798-4	2016	The resultant N, P, and F tri-doped graphene exhibited excellent electrocatalytic activities for the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER).	Oxygen	134-140	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
27667798-6	2016	The integrated unit, fabricated from the newly developed N, P, and F tri-doped graphene multifunctional metal-free catalyst, can operate in ambient air with a high gas production rate of 0.496 and 0.254 muL s-1 for hydrogen and oxygen gas, respectively, showing great potential for practical applications.	Oxygen	228-234	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	69-72
27232723-4	2016	Bi1-xBa xFeO3 of x=0.2mol% exhibited the greatest photocatalytic degradation effect after 60min of visible light irradiation, and reached 97% benzene removal efficiency, leading to production of a high concentration of carbon dioxide (CO2), with 93% and 82% reductions in chemical oxygen demand (COD) and total organic carbon (TOC), respectively.	Oxygen	281-287	transmembrane BAX inhibitor motif containing 6	Homo sapiens	0-3
27626106-7	2016	Propagation of the CO2+ interference to other ions during standard AMS and ACSM data analysis affects the calculated OA mass, mass spectra, molecular oxygen-to-carbon ratio (O/C), and f44.	Oxygen	150-156	complement C2	Homo sapiens	19-22
26825534-2	2016	In this study, computational models were used to explore how angiogenic impairment impacts oxygen availability within a fracture callus and hence regulates mesenchymal stem cell (MSC) differentiation and bone regeneration.	Oxygen	91-97	musculin	Homo sapiens	179-182
26825534-3	2016	Tissue differentiation was predicted using a previously developed algorithm which assumed that MSC fate is governed by oxygen tension and substrate stiffness.	Oxygen	119-125	musculin	Homo sapiens	95-98
27499160-3	2016	Since Malat1 was recently shown to be upregulated during hypoxia, the objective of this study was to determine the contribution of AMPK in the mechanistic pathways regulating Malat1 expression in low oxygen conditions.	Oxygen	200-206	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	175-181
27499160-4	2016	Compared to those cultured in 21% O2 conditions, HeLa cells incubated in 1.5% O2 expressed more Malat1 transcripts.	Oxygen	78-80	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	96-102
27499160-6	2016	Interestingly, pharmacological stimulation of AMPK increased Malat1 promoter transactivation in 21% O2 conditions, whereas inhibition of either AMPK or its upstream activator CaMKK completely abolished the augmentation of Malat1 under hypoxia.	Oxygen	100-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	61-67
27499160-8	2016	Overexpression of hypoxia-inducible factor-1alpha (HIF-1alpha) increased Malat1 expression in 21% O2 conditions, whereas pharmacological inhibition of HIF-1alpha blocked the impact of hypoxia on the Malat1 promoter.	Oxygen	98-100	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-79
27067371-9	2016	When the gal80 mutant with an initial cell concentration of A660 = 20 was used for batch fermentation in a complex medium containing 20 g/L xylose or 20 g/L xylitol at pH 5.0 and 30 C under oxygen limitation, the gal80 mutant consumed 100% of the xylose within 12 h, but &lt;30% of the xylitol within 100 h, indicating that xylose reductase is required for xylitol consumption in oxygen-limited conditions.	Oxygen	190-196	transcription regulator GAL80	Saccharomyces cerevisiae S288C	9-14
27067371-9	2016	When the gal80 mutant with an initial cell concentration of A660 = 20 was used for batch fermentation in a complex medium containing 20 g/L xylose or 20 g/L xylitol at pH 5.0 and 30 C under oxygen limitation, the gal80 mutant consumed 100% of the xylose within 12 h, but &lt;30% of the xylitol within 100 h, indicating that xylose reductase is required for xylitol consumption in oxygen-limited conditions.	Oxygen	380-386	transcription regulator GAL80	Saccharomyces cerevisiae S288C	9-14
27317882-0	2016	Carbamylated erythropoietin enhances mice ventilatory responses to changes in O2 but not CO2 levels.	Oxygen	78-80	erythropoietin	Mus musculus	13-27
27564658-7	2016	RESULTS: Plasma TM, which was decreased at baseline compared to controls (p&lt;0.001) increased at 90 and 180days (p=0.003), and this was directly related (r=0.57, p=0.026) to improvement of oxygen saturation (p=0.008).	Oxygen	191-197	thrombomodulin	Homo sapiens	16-18
27610633-5	2016	A crystal structure of SIRT2 in complex with a 4-ONyl peptide reveals a lone pair-pi interaction between Phe119 and the ketone oxygen of the 4-ONyl group.	Oxygen	127-133	sirtuin 2	Homo sapiens	23-28
27656882-2	2016	The reactive components of dOx comprise a Rieske structure Cys2[2Fe-2S]His2 and a non-heme reactive oxygen center (ROC).	Oxygen	100-106	Dox-3	Drosophila melanogaster	27-30
27498002-8	2016	Indirect calorimetry revealed that oxygen consumption by Atf7(-/-) mice was comparable to that of wild-type littermates on a standard chow diet, but increased energy expenditure was observed in Atf7(-/-) mice on a high-fat diet.	Oxygen	35-41	activating transcription factor 7	Mus musculus	57-61
26829052-3	2016	mTORC1 is critical to link protein synthesis activity to nutrient and oxygen levels, in part by controlling the 4E-BP1-eIF4E axis.	Oxygen	70-76	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	112-118
27505146-2	2016	First-principles DFT calculations indicate that this unusual structural arrangement can be attributed to coupling between the La/Sr A-site distribution and the rotations of the CrO6 units, which combine to relieve the local deformations of the chromium-oxygen octahedra.	Oxygen	253-259	macrophage scavenger receptor 1	Homo sapiens	129-133
27402274-2	2016	Recent studies indicated that deregulation of Cdk5 was involved in neuronal death induced by hypoxia (1% O2).	Oxygen	105-107	cyclin dependent kinase 5	Homo sapiens	46-50
27692362-2	2016	Transcription factors involved in gene regulation under low oxygen tension are the hypoxia-inducible factors, mainly HIF1A, EPAS1 and their dimerization partner HIF1B.	Oxygen	60-66	endothelial PAS domain protein 1	Homo sapiens	124-129
27692362-2	2016	Transcription factors involved in gene regulation under low oxygen tension are the hypoxia-inducible factors, mainly HIF1A, EPAS1 and their dimerization partner HIF1B.	Oxygen	60-66	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	161-166
27527871-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) is a key oxygen sensor, setting low steady-state level of hypoxia-inducible factor-alpha (HIF-alpha).	Oxygen	52-58	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-35
27527871-1	2016	Prolyl hydroxylase domain protein 2 (PHD2) is a key oxygen sensor, setting low steady-state level of hypoxia-inducible factor-alpha (HIF-alpha).	Oxygen	52-58	egl-9 family hypoxia-inducible factor 1	Mus musculus	37-41
27404666-2	2016	The C-3 stereogenic center is subsequently exploited to create the C-1 stereocenter by coordination of the nucleophilic reagent to the oxygen atom of oxazolidine.	Oxygen	135-141	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	67-70
26954154-7	2016	In summary, treatment with the appropriate concentration of ginsenoside Rg1 (20 mug/mL) can increase glucose uptake, thereby improving the quality of embryos grown in high-oxygen conditions.	Oxygen	172-178	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	72-75
27344370-6	2016	Subdivision of M2BP levels into quartiles revealed that M2BP was significantly associated with reactive oxygen metabolites, central systolic blood pressure, and radial augmentation index (AI).	Oxygen	104-110	galectin 3 binding protein	Homo sapiens	56-60
27357657-8	2016	Additionally, FADD-D mutation can reverse the severe genetic obesity phenotype of ob/ob mice, with elevated fatty acid oxidation and oxygen consumption in adipose tissue, improved insulin resistance, and decreased triglyceride storage.	Oxygen	133-139	Fas (TNFRSF6)-associated via death domain	Mus musculus	14-18
26630309-2	2016	Acute nitrate supplementation, at sea level, may reduce oxygen cost during submaximal exercise in hypobaric hypoxia.	Oxygen	56-62	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
26186992-1	2016	To investigate the role of cerebral oxygen saturation (ScO2) for prediction of hypotension after spinal anesthesia for caesarean section.	Oxygen	36-42	synthesis of cytochrome C oxidase 2	Homo sapiens	55-59
27166719-9	2016	Differences in IL-1beta levels could be because of glia population (i.e. microglia and astrocytes), mitogen-activated protein kinase and nuclear factor kappa light-chain-enhancer of activated B cells signaling pathways, and several mediators (including cyclooxygenase, neurotrophic factors, reactive oxygen species, caspases, heme oxygenase-1, and matrix metalloproteinases).	Oxygen	258-264	interleukin 1 alpha	Homo sapiens	15-23
27440994-9	2016	CONCLUSIONS: Collectively, our data show that expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF.	Oxygen	105-111	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	60-65
27440994-9	2016	CONCLUSIONS: Collectively, our data show that expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF.	Oxygen	105-111	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	186-191
27346679-4	2016	MiR-31 overexpression in partially reprogrammed iPSCs lowered SDHA expression levels and oxygen consumption rates to that of fully reprogrammed iPSCs, but did not increase the proportion of fully reprogrammed TRA1-60(+) cells in colonies unless miR-31 was co-transduced with Yamanaka factors, which resulted in a 2.7-fold increase in full reprogramming.	Oxygen	89-95	microRNA 31	Homo sapiens	0-6
27385426-3	2016	We hypothesized that BMMSCs engineered to overexpress mutant, oxygen-resistant HIF1-alpha would confer greater cardioprotection than nontransfected BMMSCs in sheep with AMI.	Oxygen	62-68	hypoxia-inducible factor 1-alpha	Ovis aries	79-89
27048753-7	2016	The V63A and N65A mutations prevented mitochondrial Ca(2+) overload and Deltapsim dysregulation as well as complex I inactivation and reactive oxygen species production while blocking mPTP opening and caspase 9 activation, possibly by reducing alpha-Syn accumulation in mitochondria.	Oxygen	143-149	synuclein, alpha	Mus musculus	244-253
27344167-9	2016	Expression of erythropoietin correlated inversely with hemoglobin oxygen saturation and positively with renin expression.	Oxygen	66-72	erythropoietin	Rattus norvegicus	14-28
27262949-8	2016	At last, we found 5% physiological oxygen was beneficial for the expression of XIST and H3K27me3 punctate enrichment, but not for the XCI pattern.	Oxygen	35-41	X inactive specific transcript	Homo sapiens	79-83
27355368-2	2016	It is known that hypoxia, a reduced oxygen level, modulates the in vitro differentiation of pluripotent cells into cardiomyocytes via hypoxia inducible factor-1alpha (HIF-1alpha)-dependent mechanisms.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	134-165
27355368-2	2016	It is known that hypoxia, a reduced oxygen level, modulates the in vitro differentiation of pluripotent cells into cardiomyocytes via hypoxia inducible factor-1alpha (HIF-1alpha)-dependent mechanisms.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	167-177
27163637-0	2016	3,3",5-triiodothyroxine inhibits apoptosis and oxidative stress by the PKM2/PKM1 ratio during oxygen-glucose deprivation/reperfusion AC16 and HCM-a cells: T3 inhibits apoptosis and oxidative stress by PKM2/PKM1 ratio.	Oxygen	94-100	pyruvate kinase M1/2	Homo sapiens	71-75
27265727-4	2016	Mechanistically, p53 activation represses the expression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of the TCA cycle intermediates oxaloacetate and NADPH, and impaired oxygen consumption.	Oxygen	215-221	transformation related protein 53, pseudogene	Mus musculus	17-20
27130530-1	2016	Chronic lung disease of prematurity (CLD) is a frequent sequela of premature birth and oxygen toxicity is a major associated risk factor.	Oxygen	87-93	lipase maturation factor 1	Mus musculus	37-40
27055905-3	2016	APPROACH AND RESULTS: Utilizing a model of oxygen-induced retinopathy, confocal microscopy and flow cytometry, we identified that retinal immunocompetent cells, microglia, express IL-17A.	Oxygen	43-49	interleukin 17A	Rattus norvegicus	180-186
27055905-10	2016	The importance of IL-17A in oxygen-induced retinopathy was confirmed by IL-17A neutralization reducing vasculopathy, VEGF, placental growth factor, tumor necrosis factor-alpha, microglial density and Muller cell, and ganglion cell injury.	Oxygen	28-34	interleukin 17A	Rattus norvegicus	18-24
27055905-10	2016	The importance of IL-17A in oxygen-induced retinopathy was confirmed by IL-17A neutralization reducing vasculopathy, VEGF, placental growth factor, tumor necrosis factor-alpha, microglial density and Muller cell, and ganglion cell injury.	Oxygen	28-34	interleukin 17A	Rattus norvegicus	72-78
27002182-5	2016	Structure-activity relationship studies and analysis of high-resolution (1.25A) PP5C-inhibitor co-crystal structures reveal close contacts between the inhibitor bridgehead oxygen and both a catalytic metal ion and a non-catalytic phenylalanine residue, the latter of which is substituted by tryptophan in PP4C.	Oxygen	172-178	protein phosphatase 4 catalytic subunit	Homo sapiens	305-309
27075446-1	2016	Photocatalytic oxidation of iron(ii) complexes by dioxygen occurred using the organic photocatalysts, 9-mesityl-10-methylacridinium ions (Acr(+)-Mes) and 2-phenyl-4-(1-naphthyl) quinolinium ions (QuPh(+)-NA), in the presence of triflic acid in acetonitrile under visible light irradiation.	Oxygen	50-58	acrosin	Homo sapiens	138-141
27075446-2	2016	The electron-transfer state of Acr(+)-Mes produced upon photoexcitation oxidized the iron(ii) complexes, whereas it reduced dioxygen with protons to produce iron(iii) complexes and H2O2.	Oxygen	124-132	acrosin	Homo sapiens	31-34
28686826-5	2016	All hospitals had some access to oxygen cylinders, which were expensive and frequently ran out.	Oxygen	33-39	RAN, member RAS oncogene family	Homo sapiens	87-90
26799785-3	2016	Here, we assess the impact of germline heterozygosity of a novel, oxygen-independent ubiquitin ligase for HIF-1alpha: hypoxia-associated factor (HAF; encoded by SART1).	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	106-116
27085616-4	2016	METHODS: Cerebral tissue oxygen saturation (ScO2) was obtained by near-infrared spectroscopy for 24 hours before and 48 hours after surgery in 43 patients.	Oxygen	25-31	synthesis of cytochrome C oxidase 2	Homo sapiens	44-48
27055125-2	2016	Correlated electronic structure calculations with the MP2, MP4, and CCSD(T) methods detail thermodynamic and kinetic information for the free radical oxygen protein oxidation pathway studied in a trialanine model system.	Oxygen	150-156	tryptase pseudogene 1	Homo sapiens	54-57
26967059-3	2016	In this report we demonstrate that Rab25 regulates HIF-1alpha protein expression in an oxygen independent manner in a panel of cancer cell lines.	Oxygen	87-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
27081066-2	2016	The inelastic scattering cross section was resonantly enhanced by "gating" the frontier orbitals of water via a chlorine-terminated tip, so the hydrogen-bonding strength can be determined with high accuracy from the red shift in the oxygen-hydrogen stretching frequency of water.	Oxygen	233-239	TOR signaling pathway regulator	Homo sapiens	132-135
26938707-6	2016	We address this drawback here by benchmarking TLES against standard MD in the simulation of O2 diffusion in myoglobin (Mb) as a case study since this model system has been extensively characterized.	Oxygen	92-94	myoglobin	Homo sapiens	108-117
26996298-0	2016	Leptin contributes to long-term stabilization of HIF-1alpha in cancer cells subjected to oxygen limiting conditions.	Oxygen	89-95	leptin	Homo sapiens	0-6
29071920-1	2016	Oxygen, an important substance for metabolism, and its related nitric oxide (NO) and carbon dioxide (CO2) play a key role in regulating physiological activities.	Oxygen	0-6	complement C2	Homo sapiens	101-104
27356800-3	2016	RESULTS: Compared to WT controls, SIRT1(+ /-) mice displayed significant decreases in both oxygen consumption and heat production[(2 681+-297) vs (3 017+-313) ml kg(-1) h(-1,) (19.05+-2.40) vs (21.15+-2.49) kcal kg(-1) h(-1,) both P&lt;0.05)], as well as an impairment in maintaining their body temperature during the cold challenge.HE staining revealed the accumulation of larger lipid droplets in BAT of SIRT1(+ /-) mice, and both immunohistochemical staining and Western blotting indicated an obvious reduction in expression of UCP1 (P&lt;0.05).	Oxygen	91-97	sirtuin 1	Mus musculus	34-39
2589887-10	1989	Ultimately lung injury appears to result from local endothelial-cell injury secondary to neutrophil-generated oxygen products that may be myeloperoxidase dependent.	Oxygen	110-116	myeloperoxidase	Rattus norvegicus	138-153
27306008-6	2016	The Gibbs free energy of AunPd2-n (+)O2x complexes with n = 1-2 and x = 1-5 is computed at temperatures 0 K, 50 K, 150 K, and 300 K. We obtain that Pd2 (+) (PdAu(+)) can adsorb 5 (4) oxygen molecules at ambient temperature; however, Au2 (+) can adsorb up to three O2 molecules when the temperature is lower than 150 K.	Oxygen	183-189	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	28-31
27306008-6	2016	The Gibbs free energy of AunPd2-n (+)O2x complexes with n = 1-2 and x = 1-5 is computed at temperatures 0 K, 50 K, 150 K, and 300 K. We obtain that Pd2 (+) (PdAu(+)) can adsorb 5 (4) oxygen molecules at ambient temperature; however, Au2 (+) can adsorb up to three O2 molecules when the temperature is lower than 150 K.	Oxygen	37-39	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	28-31
2688755-9	1989	GM-CSF induced an enhancement of the production of activated oxygen species by the cells in response to PMA.	Oxygen	61-67	colony stimulating factor 2	Homo sapiens	0-6
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	79-89
27060169-3	2016	The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha and Hif-2alpha) form dimers with their stably expressed beta subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension.	Oxygen	246-252	endothelial PAS domain protein 1	Homo sapiens	79-89
2809735-0	1989	Estimation of CBF by cerebral venous oxygen difference.	Oxygen	37-43	CCAAT enhancer binding protein zeta	Homo sapiens	14-17
27146428-3	2016	The CoP/TM electrode delivers 10 mA cm(-2) at an overpotential of 72 mV for the hydrogen evolution reaction (HER) and 310 mV for the oxygen evolution reaction (OER) in 1.0 M KOH.	Oxygen	133-139	caspase recruitment domain family member 16	Homo sapiens	4-7
2790048-6	1989	The relative affinities shown by these analogues indicated H-bonds from the carrier to the C-3, C-4 and C-5 hydroxyl oxygens and from the C-1 and C-3 hydroxyl hydrogens to the binding site.	Oxygen	117-124	complement C4A (Rodgers blood group)	Homo sapiens	96-99
26941203-7	2016	Deregulation of p66(Shc) and JunD in aged EOCs led to up-regulation of NADPH oxidase, reduced expression of manganese superoxide dismutase (MnSOD) and increased O2 (-) generation.	Oxygen	161-163	DNA polymerase delta 3, accessory subunit	Homo sapiens	16-19
2575679-5	1989	In the 3% O2, 10% O2 and 20% O2 groups, NAG, gamma-GTP and LAP were released into the media at a similar rate to that in the 95% O2 group, and anaerobic damage to the renal tubular cells was not observed.	Oxygen	10-12	LAP	Homo sapiens	45-62
27037791-3	2016	METHODS: Eleven adults with BAFME and 15 matched healthy controls underwent resting-state blood oxygen level-dependent (BOLD) fMRI scanning.	Oxygen	96-102	benign adult familial myoclonic epilepsy 1	Homo sapiens	28-33
27002144-2	2016	Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2.	Oxygen	28-34	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	169-175
27002144-3	2016	This homolog forms a complex with the oxygen-regulated hypoxia-inducible factor 2alpha and can escape translation repression.	Oxygen	38-44	endothelial PAS domain protein 1	Homo sapiens	55-86
27002144-8	2016	The oxygen-dependent activities of eIF4E and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-dependent).	Oxygen	4-10	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	45-51
27002144-8	2016	The oxygen-dependent activities of eIF4E and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-dependent).	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	186-217
27002144-8	2016	The oxygen-dependent activities of eIF4E and eIF4E2 are elucidated by observing their polysome association and the status of mammalian target of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-dependent).	Oxygen	4-10	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	230-236
2766781-4	1989	Me2SO present during cryopreservation was partially protective for mitochondrial substrate-linked oxygen consumption; however, simple exposure to and dilution from Me2SO effected some changes in mitochondrial function.	Oxygen	98-104	malic enzyme 2	Rattus norvegicus	0-3
27088801-2	2016	Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesis in the kidney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cellular oxygen sensors.	Oxygen	138-144	egl-9 family hypoxia-inducible factor 3	Mus musculus	165-169
2764573-2	1989	Expression of nitrate reductase, nitrite reductase (cytochrome cd1), and N2O reductase was controlled by discrete oxygen levels and by the nature of the nitrogenous oxide available for respiration.	Oxygen	114-120	periplasmic nitrate reductase, NapE protein	Pseudomonas stutzeri	14-31
26973343-3	2016	We recently identified a new physiologically relevant mechanism that regulates HIF-1alpha stability in the nucleus in response to cellular oxygen levels.	Oxygen	139-145	hypoxia inducible factor 1, alpha subunit	Mus musculus	79-89
26936390-11	2016	Furthermore, Trx1 siRNA increased cell death and O2 - level in SAHA-treated Phi cells.	Oxygen	49-51	thioredoxin	Homo sapiens	13-17
2764573-2	1989	Expression of nitrate reductase, nitrite reductase (cytochrome cd1), and N2O reductase was controlled by discrete oxygen levels and by the nature of the nitrogenous oxide available for respiration.	Oxygen	114-120	nitrite reductase small subunit NirD	Pseudomonas stutzeri	33-50
2764573-7	1989	With nitrous oxide as the respiratory substrate, nitrite reductase was again the most sensitive to oxygen concentration; however, thresholds for all denitrification enzymes shifted to lower oxygen levels.	Oxygen	99-105	nitrite reductase small subunit NirD	Pseudomonas stutzeri	49-66
2764573-7	1989	With nitrous oxide as the respiratory substrate, nitrite reductase was again the most sensitive to oxygen concentration; however, thresholds for all denitrification enzymes shifted to lower oxygen levels.	Oxygen	190-196	nitrite reductase small subunit NirD	Pseudomonas stutzeri	49-66
2547490-4	1989	The adenosine analogue 5"-N-ethylcarboxamide-adenosine (NECA) and L-N6-phenyl-isopropyl-adenosine (L-PIA) inhibited PMN oxygen metabolite generation with relative potencies (NECA greater than adenosine greater than L-PIA) characteristic of an A2 receptor.	Oxygen	120-126	RPTOR independent companion of MTOR complex 2	Homo sapiens	101-104
26856676-3	2016	The Von Hippel-Lindau protein (pVHL) drives the degradation of oxygen-sensitive subunit HIF-1alpha that controls the activity of HIF-1.	Oxygen	63-69	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-98
2759947-3	1989	The differential effects of CO on the carotid body and erythropoietin-producing tissue would also indicate that the effect of hypoxic hypoxia on the carotid body is the result of a direct action of a local low O2 stimulus rather than secondary to a systemic effect initiated by other O2-sensing tissues.	Oxygen	210-212	erythropoietin	Rattus norvegicus	55-69
26778425-0	2016	Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2.	Oxygen	141-143	solute carrier family 31 member 1	Homo sapiens	67-87
26778425-11	2016	Peptides that deviate from the native Ctr1 pattern were less effective at forming stable Cu(I)-peptide complexes and/or resulted in O2-dependent oxidative damage to the peptide.	Oxygen	132-134	solute carrier family 31 member 1	Homo sapiens	38-42
26768136-2	2016	We found that c-Fos expression in the mitochondria of neuroblastoma Neuro2a cells was augmented by oxygen and glucose deprivation (OGD), which is a common in vitro model for brain ischemia.	Oxygen	99-105	FBJ osteosarcoma oncogene	Mus musculus	14-19
2550765-6	1989	By monitoring the beta-galactosidase activity of a CBS1/lacZ fusion construct we show that expression of CBS1 is subjected to regulation by oxygen and by glucose: the beta-galactosidase activity is elevated threefold in glycerol or galactose grown cells compared to that in glucose grown cells.	Oxygen	140-146	Cbs1p	Saccharomyces cerevisiae S288C	51-55
27085901-9	2016	Simulations also predict that myosin-activating drugs may partially counteract the effects of energetic state on cross-bridge mechanics in heart failure while increasing myocardial oxygen consumption.	Oxygen	181-187	myosin heavy chain 14	Homo sapiens	30-36
2550765-6	1989	By monitoring the beta-galactosidase activity of a CBS1/lacZ fusion construct we show that expression of CBS1 is subjected to regulation by oxygen and by glucose: the beta-galactosidase activity is elevated threefold in glycerol or galactose grown cells compared to that in glucose grown cells.	Oxygen	140-146	Cbs1p	Saccharomyces cerevisiae S288C	105-109
2799104-0	1989	O2-supply to the kidneys and the production of erythropoietin.	Oxygen	0-2	erythropoietin	Rattus norvegicus	47-61
26921340-10	2016	Therefore, we demonstrate that downregulation of PHD3 augments metastatic spread in human colorectal cancer and identify MCL-1 as a novel downstream effector of oxygen sensing.	Oxygen	161-167	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	121-126
27010502-5	2016	In addition, the interaction of p53 with Mdmx was lost by replacing a sulfur atom with an oxygen atom in 1b and 1c.	Oxygen	90-96	transformation related protein 53, pseudogene	Mus musculus	32-35
2656688-2	1989	A 299-base pair-long fragment from the 5"-flanking region of the ANB1 gene was found to confer oxygen-mediated negative regulation to an heterologous CYC1-LacZ hybrid gene.	Oxygen	95-101	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	150-154
26998531-1	2016	Spontaneous electron transport to molecular oxygen led to regeneration of oxidised nicotinamide cofactor in cell lysates that contain an alcohol dehydrogenase, a quinone reductase and a quinone mediator.	Oxygen	44-50	Alcohol dehydrogenase	Escherichia coli	137-158
2719123-1	1989	Regulation of renal erythropoietin (EPO) production is based on an intrarenal oxygen sensor.	Oxygen	78-84	erythropoietin	Mus musculus	20-34
27067254-4	2016	Notably, Glut1 upregulation in response to TCR stimulation was significantly higher in T lymphocytes activated under hypoxic as compared to atmospheric oxygen conditions.	Oxygen	152-158	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	43-46
27800506-5	2016	Our original model of Epo-deficient (Epo-TAgh) mice allowed us to improve our knowledge of the possible role of Epo in O2 homeostasis.	Oxygen	119-121	erythropoietin	Mus musculus	22-25
27800506-5	2016	Our original model of Epo-deficient (Epo-TAgh) mice allowed us to improve our knowledge of the possible role of Epo in O2 homeostasis.	Oxygen	119-121	erythropoietin	Mus musculus	37-40
27800506-5	2016	Our original model of Epo-deficient (Epo-TAgh) mice allowed us to improve our knowledge of the possible role of Epo in O2 homeostasis.	Oxygen	119-121	erythropoietin	Mus musculus	37-40
2719123-1	1989	Regulation of renal erythropoietin (EPO) production is based on an intrarenal oxygen sensor.	Oxygen	78-84	erythropoietin	Mus musculus	36-39
26724922-4	2016	The structural requirement for the recognition by LAT1 was to have carbonyl oxygen, alkoxy oxygen of carboxyl group, amino group and hydrophobic side chain.	Oxygen	76-82	solute carrier family 7 member 5	Homo sapiens	50-54
2719123-6	1989	Acetazolamide on the other hand, which is thought to act predominantly at the proximal tubular site, significantly reduced EPO formation in response to normobaric hypoxia (8 and 14% O2) and functional anemia (0.1% carbon monoxide).	Oxygen	182-184	erythropoietin	Mus musculus	123-126
26724922-4	2016	The structural requirement for the recognition by LAT1 was to have carbonyl oxygen, alkoxy oxygen of carboxyl group, amino group and hydrophobic side chain.	Oxygen	91-97	solute carrier family 7 member 5	Homo sapiens	50-54
2650631-10	1989	Recently, it was found in our laboratory that GST-P, GST-pi and even mouse GST II in Class pi, all are very strongly inactivated by SH-modifiers and active oxygens, indicating that these properties may be useful for overcoming MDR, if the forms really are involved with MDR.	Oxygen	156-163	hematopoietic prostaglandin D synthase	Rattus norvegicus	46-49
27066464-15	2016	O2 requirements at ICU transfer positively correlated with day 7 MMP-8 (r = 0.85, p = 0.016) and Ang-2 levels (r = 0.79, p = 0.036) in the placebo group and inversely correlated with day 7 sICAM-1 levels (r = -0.91, p = 0.005) in the MPT group.	Oxygen	0-2	matrix metallopeptidase 8	Homo sapiens	65-70
26408609-7	2016	B2R is instrumental for the supply of blood, oxygen and nutrition to tissues.	Oxygen	45-51	bradykinin receptor B2	Homo sapiens	0-3
26854136-10	2016	Levels of ROS, Bax, caspase-3 and BACE were increased, whereas expression of Bcl-2 was decreased, in cells treated with 95% oxygen plus 2.4% isoflurane compared with the control and 2.4% isoflurane plus air groups.	Oxygen	124-130	BCL2 associated X, apoptosis regulator	Rattus norvegicus	15-18
2650631-10	1989	Recently, it was found in our laboratory that GST-P, GST-pi and even mouse GST II in Class pi, all are very strongly inactivated by SH-modifiers and active oxygens, indicating that these properties may be useful for overcoming MDR, if the forms really are involved with MDR.	Oxygen	156-163	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-56
26872098-0	2016	Normobaric oxygen therapy inhibits HIF-1alpha and VEGF expression in perihematoma and reduces neurological function defects.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	50-54
2650631-10	1989	Recently, it was found in our laboratory that GST-P, GST-pi and even mouse GST II in Class pi, all are very strongly inactivated by SH-modifiers and active oxygens, indicating that these properties may be useful for overcoming MDR, if the forms really are involved with MDR.	Oxygen	156-163	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-56
26872098-10	2016	These results suggest that NBO therapy with oxygen delivered at 90% conferred best neuroprotection to ICH rats, potentially through amelioration of brain edema by suppressing HIF-1alpha and VEGF expression in the perihematoma.	Oxygen	44-50	vascular endothelial growth factor A	Rattus norvegicus	190-194
2539325-4	1989	In vitro treatment with recombinant interferon-gamma (rIFN-gamma) caused an enhancement of the capability of AM of inactive sarcoid patients to produce O2- in response to PMA.	Oxygen	152-154	interferon gamma	Rattus norvegicus	54-64
26759234-7	2016	HIF1alpha, but not HIF2alpha, induced Warburg-like metabolism characterized by increased glycolysis, decreased oxygen consumption, and decreased ATP production in mouse embryonic fibroblasts, providing insights into the cellular changes potentially occurring in Vhl mutant renal cells before ccRCC formation.	Oxygen	111-117	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
2721763-1	1989	The data obtained revealed that the level of 2,3-DPH in erythrocytes and that of erythropoietin in the blood plasma were important compensatory mechanisms for regulation of the oxygen transport and the erythropoiesis in alteration of the blood erythrocyte composition in rats.	Oxygen	177-183	erythropoietin	Rattus norvegicus	81-95
26846855-0	2016	Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.	Oxygen	0-6	erythropoietin receptor	Homo sapiens	31-54
26846855-6	2016	These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL disease.	Oxygen	119-125	erythropoietin receptor	Homo sapiens	23-27
26713889-0	2016	Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9.	Oxygen	7-13	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	92-98
26926497-2	2016	The BEt3/O2-initiated iodine-atom-transfer radical cyclization reactions of substituted N-(but-3-en-1-yl)-N-(tert-butyl)-2-iodoalkanamides were carried out, which led to the predominant formations of 3,4-cis, 4,5-trans, or 4,6-trans substituted delta-lactams.	Oxygen	9-11	trafficking protein particle complex subunit 3	Homo sapiens	4-8
2912744-8	1989	These findings suggest that the correlation between erythropoietic activity and growth rate in the growing rat is the result of an erythropoietin-dependent operating mechanism, which appears to be independent of the ratio tissue oxygen supply/tissue oxygen demand.	Oxygen	229-235	erythropoietin	Rattus norvegicus	131-145
26937679-7	2016	Ag2O formed at low O2 partial pressure, whereas AgO formed at atmospheric pressure.	Oxygen	19-21	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	0-3
2912744-8	1989	These findings suggest that the correlation between erythropoietic activity and growth rate in the growing rat is the result of an erythropoietin-dependent operating mechanism, which appears to be independent of the ratio tissue oxygen supply/tissue oxygen demand.	Oxygen	250-256	erythropoietin	Rattus norvegicus	131-145
26838789-7	2016	Induction of O2 (-) production in H9C2 cardiac myocytes led to the release of a transferable factor able to induce peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ expression in cocultured EpAT.	Oxygen	13-15	peroxisome proliferator activated receptor gamma	Sus scrofa	115-163
2492266-10	1989	These results indicate that rIFN-gamma per se is able to activate peritoneal macrophages to induce Salmonella-killing activity and suggest that increased phagosome-lysosome fusion followed by an oxygen-independent killing mechanism is primarily responsible for the enhanced Salmonella-killing activity in rIFN-gamma-activated macrophages.	Oxygen	195-201	interferon gamma	Rattus norvegicus	28-38
26822702-2	2016	We use (19)F NMR chemical shifts in the MgF3(-) transition state analogue (TSA) complex as a spectroscopic reporter to indicate electron distribution for the gamma-PO3(-) oxygens in the corresponding TS, implying that oxygen coordinated to Mg has the greatest electron density.	Oxygen	171-178	signal transducer and activator of transcription 5A	Homo sapiens	40-43
26822702-2	2016	We use (19)F NMR chemical shifts in the MgF3(-) transition state analogue (TSA) complex as a spectroscopic reporter to indicate electron distribution for the gamma-PO3(-) oxygens in the corresponding TS, implying that oxygen coordinated to Mg has the greatest electron density.	Oxygen	171-177	signal transducer and activator of transcription 5A	Homo sapiens	40-43
26896479-7	2016	Infusion of the beta3 AR agonist CL316243 (CL) decreased eNOS-GSS, reduced O2 ( -), restored NO levels, and improved endothelium-dependent relaxation.	Oxygen	75-77	adrenoceptor beta 3	Homo sapiens	16-24
26989608-3	2016	Pichia stipitis ADH2 is regulated by oxygen instead of glucose, whereas Kluyveromyces marxianus ADH2 is regulated by neither glucose nor ethanol.	Oxygen	37-43	alcohol dehydrogenase ADH2	Saccharomyces cerevisiae S288C	16-20
26819475-5	2016	The hydroxylation by JMJD6 is oxygen dependent.	Oxygen	30-36	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	21-26
26819475-7	2016	We assessed whether oxygen-sensing JMJD6 is differentially expressed in preeclamptic placenta and regulates sFLT-1 splicing in placenta via U2AF65.	Oxygen	20-26	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	35-40
26819475-7	2016	We assessed whether oxygen-sensing JMJD6 is differentially expressed in preeclamptic placenta and regulates sFLT-1 splicing in placenta via U2AF65.	Oxygen	20-26	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	140-146
26760116-5	2016	We hypothesized that IGF-1 and IGF-2 signal via distinct signaling pathways under low-oxygen tension to maintain PMSC multipotency.	Oxygen	86-92	insulin like growth factor 2	Homo sapiens	31-36
26760116-6	2016	In preterm PMSCs, low-oxygen tension increased the expression of IGF-2 and reduced IGF-1.	Oxygen	22-28	insulin like growth factor 2	Homo sapiens	65-70
26760116-9	2016	This IGF/low oxygen tension-mediated proliferation was receptor dependent because neutralization of the IGF-1R inhibited PMSC proliferation in the presence of IGF-1 and the IR in presence of IGF-2.	Oxygen	13-19	insulin like growth factor 2	Homo sapiens	191-196
26760116-11	2016	We conclude that low-oxygen tension can modify the IGF-1 or IGF-2 signaling via the IGF-1R and IR in PMSCs.	Oxygen	21-27	insulin like growth factor 2	Homo sapiens	60-65
31245482-5	2016	In a culture study, Epo promoted BMMSC proliferation in normoxia and enhanced cell survival under the culture condition mimicking ischemia (1% oxygen and nutrient deprivation).	Oxygen	143-149	erythropoietin	Rattus norvegicus	20-23
2551143-5	1989	Using the mean oxygen consumption rate of 10 ml O2/100 g tissue/sec in beating heart, oxygen gradients of 3.9 and 4.6 nmol was predicted across the intact and phospholipase-A2 treated mitochondrial membranes, respectively.	Oxygen	15-21	phospholipase A2 group IB	Rattus norvegicus	159-175
26772821-4	2016	Polarographic analysis revealed that leptin increased oxygen consumption rate and cellular ATP levels were more dependent on mitochondrial oxidative metabolism in leptin-treated cells compared to the more glycolytic control cells.	Oxygen	54-60	leptin	Homo sapiens	37-43
26772821-4	2016	Polarographic analysis revealed that leptin increased oxygen consumption rate and cellular ATP levels were more dependent on mitochondrial oxidative metabolism in leptin-treated cells compared to the more glycolytic control cells.	Oxygen	54-60	leptin	Homo sapiens	163-169
26782770-0	2016	Nanoporous PdCr alloys as highly active electrocatalysts for oxygen reduction reaction.	Oxygen	61-67	2,4-dienoyl-CoA reductase 2	Homo sapiens	11-15
2551143-5	1989	Using the mean oxygen consumption rate of 10 ml O2/100 g tissue/sec in beating heart, oxygen gradients of 3.9 and 4.6 nmol was predicted across the intact and phospholipase-A2 treated mitochondrial membranes, respectively.	Oxygen	48-50	phospholipase A2 group IB	Rattus norvegicus	159-175
2551143-5	1989	Using the mean oxygen consumption rate of 10 ml O2/100 g tissue/sec in beating heart, oxygen gradients of 3.9 and 4.6 nmol was predicted across the intact and phospholipase-A2 treated mitochondrial membranes, respectively.	Oxygen	86-92	phospholipase A2 group IB	Rattus norvegicus	159-175
2551143-9	1989	Phospholipase A2, which is known to be activated in ischemia, destroys the microstructure of myocardial cells, seems deleterious to oxygen transport to cytochrome a,a3.	Oxygen	132-138	phospholipase A2 group IB	Rattus norvegicus	0-16
26721946-8	2016	Under short-term severe hypoxia (1% O2), MST4 protection from hypoxia-induced apoptosis was abrogated in the presence of hesperadin.	Oxygen	36-38	serine/threonine kinase 26	Homo sapiens	41-45
2744579-7	1989	It is suggested that, when oxygen is limiting, myoglobin may serve as a protector of muscle cells against peroxides and other oxidants.	Oxygen	27-33	myoglobin	Homo sapiens	47-56
26841115-4	2016	Hypoxia inducible factor-1alpha (HIF-1alpha) has been identified as a key mediator for chondrocytes to response to fluctuations of oxygen availability during cartilage development or repair.	Oxygen	131-137	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
26841115-4	2016	Hypoxia inducible factor-1alpha (HIF-1alpha) has been identified as a key mediator for chondrocytes to response to fluctuations of oxygen availability during cartilage development or repair.	Oxygen	131-137	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
2662543-2	1989	The revealed differences in the autooxidation rate of the studied myoglobins are explained by differences in the conformational state of a protein globule, which more actively protects a heme (in semi-aquatic animals) from spontaneous oxidation under conditions of muscular saturation of cells with oxygen, which is confirmed by the results obtained from the analysis of the universal links of pair amino acid residues which stabilize the protein molecule, 2,3-DPG and carnosine decrease the resistance of myoglobin to autooxidation.	Oxygen	299-305	myoglobin	Homo sapiens	66-75
26752460-3	2016	Under the optimal OFA damper opening (i.e, 55%), NOx emissions and carbon in fly ash attained levels of 589 mg/m(3) at 6% O2 and 6.18%, respectively, achieving NOx and carbon in fly ash significant reduction by 33% and 37%, respectively.	Oxygen	122-124	NADPH oxidase	Drosophila melanogaster	49-52
26805749-5	2016	Catalysis results from combination of both electrostatic stabilization reducing the negative electron density on the PO3(=) oxygens and monoester dianion destabilization by the steric effects of close NMe3(+) groups hindering the hydrogen-bonding with water and destabilising the monoester dianion.	Oxygen	124-131	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	201-205
2906805-4	1988	In the reactions catalyzed by the E. coli enzymes, both NMR and quantitative mass spectral analyses established that transfer of the oxygen isotope from the substrate 18O-enriched carboxyl group to Pi occurred, thereby providing strong evidence for an acyl phosphate intermediate in both the FPGS- and DHFS-catalyzed reactions.	Oxygen	133-139	folylpolyglutamate synthase	Homo sapiens	292-296
26703470-4	2016	We characterize here the kinetic and inhibitory properties of Tets and show that the Km value of Tets 1 and 2 for O2 is 30 mum, indicating that they retain high activity even under hypoxic conditions.	Oxygen	114-116	tet methylcytosine dioxygenase 1	Homo sapiens	97-109
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Oxygen	63-69	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	75-80
27571978-5	2016	Our results demonstrate that formyl peptide receptor 1 (FPR1) and neutrophilic NADPH oxidase (NOX2) are required for the rapid depletion of microenvironmental oxygen and compensatory responses, resulting in a dramatic enrichment of an anaerobic bacterial consortium.	Oxygen	159-165	formyl peptide receptor 1	Mus musculus	29-54
27571978-5	2016	Our results demonstrate that formyl peptide receptor 1 (FPR1) and neutrophilic NADPH oxidase (NOX2) are required for the rapid depletion of microenvironmental oxygen and compensatory responses, resulting in a dramatic enrichment of an anaerobic bacterial consortium.	Oxygen	159-165	formyl peptide receptor 1	Mus musculus	56-60
26791224-2	2016	In the nematode Caenorhabditis elegans, a complex of sGCs, GCY-35 and GCY-36, functions in oxygen (O2) sensing.	Oxygen	91-97	Soluble guanylate cyclase gcy-36	Caenorhabditis elegans	70-76
27096055-6	2016	The oxygen atom of Lys58 in FABP4 was found to be very important for strong interactions with FABP4.	Oxygen	4-10	fatty acid binding protein 4	Homo sapiens	28-33
27096055-6	2016	The oxygen atom of Lys58 in FABP4 was found to be very important for strong interactions with FABP4.	Oxygen	4-10	fatty acid binding protein 4	Homo sapiens	94-99
26885373-5	2016	Monomeric ANXA2 (ANXA2m) was identified as a TLR2-binding protein enriched in 5 % O2 by mass spectrometry.	Oxygen	82-84	annexin A2	Mus musculus	10-15
2974846-2	1988	Continuous hypoxic ventilation with 11% O2 was associated with a uniform but transient increase of plasma immunoreactive (ir) ANF that peaked at 15 min.	Oxygen	40-42	natriuretic peptides A	Sus scrofa	126-129
26885373-5	2016	Monomeric ANXA2 (ANXA2m) was identified as a TLR2-binding protein enriched in 5 % O2 by mass spectrometry.	Oxygen	82-84	annexin A2	Mus musculus	17-23
26885373-9	2016	RESULTS: ANXA2m is overexpressed by murine glioblastoma GL261 cells grown under 5 % O2, but not atmospheric 20 % O2, and acts as an adjuvant by inducing murine and human DC maturation through TLR2.	Oxygen	84-86	annexin A2	Mus musculus	9-14
27040637-5	2016	Treatment with hypoxia mimetic CoCl2 or low O2 incubation up-regulated MEF mRNA and protein levels in various cell lines.	Oxygen	44-46	E74 like ETS transcription factor 4	Homo sapiens	71-74
2848333-13	1988	We have concluded that in the rabbit lung IDO is able to scavenge O2- and therefore has the potential to act as a protective enzyme in this species.	Oxygen	66-68	indoleamine 2,3-dioxygenase 1	Mus musculus	42-45
25891298-6	2016	Patients in arm 1 had statistically significant improvement in their AHI (18.1 +- 13.0 to 7.4 +- 10.1, P &lt; .001), oxygen desaturation index (ODI) (16.3 +- 10.8 to 8.2 +- 9.0, P &lt; .001), and minimum oxygen saturation (81.3% +- 6.7% to 86.9% +- 5.6%, P = 0.008) from baseline sleep study to sleep study 2.	Oxygen	117-123	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	12-17
26518179-0	2016	The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats.	Oxygen	79-85	vascular endothelial growth factor A	Rattus norvegicus	27-61
26518179-2	2016	Increased VEGF may affect inner retinal oxygen delivery (DO2) and oxygen metabolism (MO2), however, quantitative information is lacking.	Oxygen	40-46	vascular endothelial growth factor A	Rattus norvegicus	10-14
26518179-2	2016	Increased VEGF may affect inner retinal oxygen delivery (DO2) and oxygen metabolism (MO2), however, quantitative information is lacking.	Oxygen	66-72	vascular endothelial growth factor A	Rattus norvegicus	10-14
25891298-6	2016	Patients in arm 1 had statistically significant improvement in their AHI (18.1 +- 13.0 to 7.4 +- 10.1, P &lt; .001), oxygen desaturation index (ODI) (16.3 +- 10.8 to 8.2 +- 9.0, P &lt; .001), and minimum oxygen saturation (81.3% +- 6.7% to 86.9% +- 5.6%, P = 0.008) from baseline sleep study to sleep study 2.	Oxygen	204-210	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	12-17
3060768-3	1988	Although there have been no systematic investigations of the value of oxygen therapy in OP poisoning, it may improve the efficiency of ChE reactivation by the standard therapies of cholinolytics and oximes.	Oxygen	70-76	butyrylcholinesterase	Homo sapiens	135-138
27236673-5	2016	We recently demonstrated that mouse MSCs are highly sensitive to oxidative stress, and long-term expansion of these cells in atmospheric oxygen selects for immortalized clones that lack a functional p53 protein.	Oxygen	137-143	transformation related protein 53, pseudogene	Mus musculus	199-202
26518179-11	2016	DO2 was 950 +- 340 and 1380 +- 650 nL O2/min in control and VEGF-injected eyes, respectively (P = 0.005).	Oxygen	1-3	vascular endothelial growth factor A	Rattus norvegicus	60-64
26454446-9	2016	Our results showed that EPO pretreatment alleviated seawater aspiration-induced ALI, as indicated by increased arterial partial oxygen tension and decreased lung histological scores.	Oxygen	128-134	erythropoietin	Rattus norvegicus	24-27
3391643-7	1988	Furthermore, PHA-stimulated monocytes exposed to O2 produced more IL-1 than control cells.	Oxygen	49-51	interleukin 1 alpha	Homo sapiens	66-70
26577812-2	2016	Further studies have shown that the oxygen-dependent transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is involved in these processes.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	74-105
27034888-7	2016	This pathway was further stressed by dysregulations of oxygen sensor EGLN3 and of nuclear TMPO.	Oxygen	55-61	egl-9 family hypoxia-inducible factor 3	Mus musculus	69-74
3391643-11	1988	By contrast, exposure to O2 induced increases in the production of both IL-1 and IL-2 that may not be related to alterations in the thiol status of the cell.	Oxygen	25-27	interleukin 1 alpha	Homo sapiens	72-76
26577812-2	2016	Further studies have shown that the oxygen-dependent transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is involved in these processes.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	107-117
26880989-6	2016	Knockdown of integrin alpha 4 by integrin alpha 4 siRNA (siITGA4) treatment increased BM-MSC migration by upregulation of ROCK1, Rac1/2/3, and matrix metalloproteinase-2 regardless of oxygen tension.	Oxygen	184-190	integrin subunit alpha 4	Homo sapiens	13-29
2841577-2	1988	Oxygen regulation is mediated by the expression of the CYP1 gene, and the CYP1 protein interacts with both CYC1 upstream activation sequence 1 (UAS1) and CYC7 UASo.	Oxygen	0-6	Hap1p	Saccharomyces cerevisiae S288C	55-59
26880989-6	2016	Knockdown of integrin alpha 4 by integrin alpha 4 siRNA (siITGA4) treatment increased BM-MSC migration by upregulation of ROCK1, Rac1/2/3, and matrix metalloproteinase-2 regardless of oxygen tension.	Oxygen	184-190	integrin subunit alpha 4	Homo sapiens	33-49
26791224-2	2016	In the nematode Caenorhabditis elegans, a complex of sGCs, GCY-35 and GCY-36, functions in oxygen (O2) sensing.	Oxygen	99-101	Soluble guanylate cyclase gcy-36	Caenorhabditis elegans	70-76
2841577-2	1988	Oxygen regulation is mediated by the expression of the CYP1 gene, and the CYP1 protein interacts with both CYC1 upstream activation sequence 1 (UAS1) and CYC7 UASo.	Oxygen	0-6	Hap1p	Saccharomyces cerevisiae S288C	74-78
2841577-2	1988	Oxygen regulation is mediated by the expression of the CYP1 gene, and the CYP1 protein interacts with both CYC1 upstream activation sequence 1 (UAS1) and CYC7 UASo.	Oxygen	0-6	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	107-111
2841577-5	1988	Directed mutagenesis changing these GC residues to CG residues in CYC7 led to CYC1-like expression of CYC7 both in a CYP1 wild-type strain and in a strain carrying the semidominant mutation CYP1-16 which reverses the oxygen-dependent expression of the two genes.	Oxygen	217-223	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	78-82
26549301-2	2016	Quantitative O2 imaging (QUO2) applies a biophysical model to measure OEF in tissue from BOLD, cerebral blood flow (CBF), and end-tidal O2 (ETO2) signals acquired during two or more gas manipulations.	Oxygen	13-15	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	126-138
26765566-0	2016	An oxygen-insensitive Hif-3alpha isoform inhibits Wnt signaling by destabilizing the nuclear beta-catenin complex.	Oxygen	3-9	catenin beta 1	Homo sapiens	93-105
26765566-10	2016	These findings provide new insights into the oxygen-independent actions of HIFs and uncover a novel mechanism regulating Wnt/beta-catenin signaling.	Oxygen	45-51	catenin beta 1	Homo sapiens	125-137
26766745-5	2016	In vitro, the levels of IL-6 release and the levels of IL-6R and STAT3 expression were increased in both primary neurons and astrocytes subjected to oxygen and glucose deprivation (OGD) following MSCs co-culture.	Oxygen	149-155	signal transducer and activator of transcription 3	Rattus norvegicus	65-70
26642257-0	2015	Ultrafine CoP Nanoparticles Supported on Carbon Nanotubes as Highly Active Electrocatalyst for Both Oxygen and Hydrogen Evolution in Basic Media.	Oxygen	100-106	caspase recruitment domain family member 16	Homo sapiens	10-13
26670043-4	2015	Here, we report a dynamic enhancement of oxygen consumption and mitochondrial ATP generation in irradiated normal cells, paralleled with increased mitochondrial relocation of the cell-cycle kinase CDK1 and nuclear DNA repair.	Oxygen	41-47	cyclin dependent kinase 1	Homo sapiens	197-201
2841577-5	1988	Directed mutagenesis changing these GC residues to CG residues in CYC7 led to CYC1-like expression of CYC7 both in a CYP1 wild-type strain and in a strain carrying the semidominant mutation CYP1-16 which reverses the oxygen-dependent expression of the two genes.	Oxygen	217-223	Hap1p	Saccharomyces cerevisiae S288C	190-194
3277502-3	1988	We studied effects of administering catalase, which catalyzes conversion of hydrogen peroxide to oxygen and water, to sheep subsequently infused with endotoxin to test the hypothesis that hydrogen peroxide plays a role in the pathogenesis of lung injury.	Oxygen	97-103	catalase	Ovis aries	36-44
26697402-10	2015	COX1-2 require oxygen for catalytic activity, and we further show that PGE2 production is markedly suppressed in cells cultured under low (1%) oxygen concentration.	Oxygen	15-21	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
26697402-10	2015	COX1-2 require oxygen for catalytic activity, and we further show that PGE2 production is markedly suppressed in cells cultured under low (1%) oxygen concentration.	Oxygen	143-149	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
26970791-7	2016	The best MPP-modified PUF showed oxygen index 24.6.	Oxygen	33-39	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	22-25
2833227-0	1988	Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages.	Oxygen	125-131	PCNA clamp associated factor	Homo sapiens	0-26
26927340-2	2016	Hypoxia-inducible factor-1alpha(HIF-1alpha) is a core transcription factor for restoring homeostasis in intracellular oxygen and has a crucial role in preventing the development of DCM.	Oxygen	118-124	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
26927340-2	2016	Hypoxia-inducible factor-1alpha(HIF-1alpha) is a core transcription factor for restoring homeostasis in intracellular oxygen and has a crucial role in preventing the development of DCM.	Oxygen	118-124	hypoxia inducible factor 1, alpha subunit	Mus musculus	32-42
26151122-3	2015	Similarly, the capacity of osteoblastic cells to perceive pericellular oxygen has a profound effect on skeletal mass and architecture, as mice expressing stable hypoxia-inducible factor (HIF)-1alpha and -2alpha demonstrate age-dependent increases in bone volume per tissue volume and osteoblast number.	Oxygen	71-77	hypoxia inducible factor 1, alpha subunit	Mus musculus	161-210
26151122-8	2015	Taken together, these data introduce PTH as a regulator of oxygen-independent HIF-1alpha levels through a mechanism involving cyclic AMP, Hsp90, and the cytoskeleton.	Oxygen	59-65	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-88
3334866-5	1988	Oxygen deprivation of the myocardial cells for 4 h resulted in a sharp reduction of both phospholipase A2 and A1 activities.	Oxygen	0-6	phospholipase A2 group IB	Rattus norvegicus	89-105
29861948-5	2015	Electro-catalytic oxygen reduction (ORR) and methanol oxidation (MOR) on these catalysts showed dramatic enhancements for both cathodic and anodic electrocatalysis in fuel cells, which were attributed to their unique morphology and crystalline structure, as well as synergetic effect of the multi-metallic components.	Oxygen	18-24	opioid receptor mu 1	Homo sapiens	65-68
26667076-3	2016	Due to the daily changes in tissue oxygen levels in the intestine, the hypoxic transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are essential in maintaining intestinal homeostasis.	Oxygen	35-41	endothelial PAS domain protein 1	Homo sapiens	143-153
27119348-11	2016	Experimental inhibition of p53 with Sip53 blocked GA-induced decrease of the oxygen consumption rate and cell viability, and blocked the increase of apoptosis.	Oxygen	77-83	transformation related protein 53, pseudogene	Mus musculus	27-30
3364298-4	1988	The myoglobin level was considered to closely correlate with mechanical performance and therefore oxygen demands of the gizzards.	Oxygen	98-104	myoglobin	Homo sapiens	4-13
2838494-2	1988	It has been verified that toxic hepatitis induced by galactosamine is similar to that of CCl4 poisoning, and that both were inhibited by O2* scavengers.	Oxygen	137-139	C-C motif chemokine ligand 4	Homo sapiens	89-93
26330493-14	2016	Under anaerobic conditions, both Id1 and c-Myc are down-regulated (50-70%), and overexpression of oxygen-insensitive hypoxia-inducible factor 1alpha (Hif1alpha) or its downstream target Mxi1 resulted in a significant reduction of c-Myc and Id1 (~70%), suggesting that Hif1alpha suppresses Id1 and c-Myc under anaerobic conditions via Mxi1.	Oxygen	98-104	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-148
26769839-5	2015	Exposure to &gt; 96% oxygen for 60 minutes significantly changed the expression of 20 different genes, including upregulation of two different humanins - MTRNR2L2 and MTRNR2L8, and activated a "cell survival" network as detected by Ingenuity Pathway Analyses.	Oxygen	21-27	MT-RNR2 like 8 (pseudogene)	Homo sapiens	167-175
26624889-9	2015	Furthermore, to demonstrate the utility of the developed sensing system, we demonstrated the mapping of the oxygen consumption rate of rat brain slices and succeeded in visualizing a clear difference among the layer structures of the hippocampus, i.e., the cornu ammonis (CA1 and CA3) and dentate gyrus (DG).	Oxygen	108-114	carbonic anhydrase 1	Rattus norvegicus	272-275
3145286-0	1988	Effects of sodium valproate and oxygen on the CD-1 mouse fetus.	Oxygen	32-38	CD1 antigen complex	Mus musculus	46-50
26596942-3	2016	NI that were incorporated by the mitochondrial RNA polymerase (PolRMT) inhibited mitochondrial protein synthesis and showed a corresponding decrease in mitochondrial oxygen consumption in cells.	Oxygen	166-172	RNA polymerase mitochondrial	Homo sapiens	63-69
26644182-2	2016	PHD1 is also able to regulate mitotic progression through the regulation of the crucial centrosomal protein Cep192, establishing a link between the oxygen-sensing and the cell cycle machinery.	Oxygen	148-154	centrosomal protein 192	Homo sapiens	108-114
27403445-12	2016	In culture, macrophages exposed to cigarette smoke and oxygen also demonstrated decreased TNF-alpha secretion and enhanced phagocytosis of PAO1 bacteria.	Oxygen	55-61	spermine oxidase	Mus musculus	139-143
3442661-5	1987	Application of this method to ATP in equilibrium with HOH exchange during single turnovers of myosin indicates that the bulk of the ATP undergoes rapid washout of gamma-nonbridge oxygens in the virtual absence of PIX.	Oxygen	179-186	myosin heavy chain 14	Homo sapiens	94-100
27194935-6	2016	Methionines on residues 215 (215), 438 (438), 853 (851), 856 (854), 1071 (1069), and 1106 (1104) of myosin-1 (myosin-4) were oxidized by the addition of oxygen.	Oxygen	153-159	myosin heavy chain 4	Homo sapiens	110-118
27492181-2	2016	Measurements of transdiaphragmatic pressure (Pdi) can be conducted during eupnea, hypoxia (10 % O2)-hypercapnia (5 % CO2), chemical airway stimulation (i.e., sneezing), spontaneously occurring deep breaths (i.e., sighs), sustained airway or tracheal occlusion, and maximal efforts elicited via bilateral phrenic nerve stimulation, representing the full range of motor behaviors available by the diaphragm muscle.	Oxygen	96-98	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	45-48
26356798-2	2015	In this report, scanning tunneling microscopy was used to study a Pt1-6/Fe3O4 model catalyst exposed to CO, H2, O2, and mixtures thereof at 550 K. CO extracts lattice oxygen atoms at the cluster perimeter to form CO2, creating large holes in the metal oxide surface.	Oxygen	112-114	zinc finger protein 77	Homo sapiens	66-71
26356798-2	2015	In this report, scanning tunneling microscopy was used to study a Pt1-6/Fe3O4 model catalyst exposed to CO, H2, O2, and mixtures thereof at 550 K. CO extracts lattice oxygen atoms at the cluster perimeter to form CO2, creating large holes in the metal oxide surface.	Oxygen	167-173	zinc finger protein 77	Homo sapiens	66-71
26578671-0	2015	Letter by Teerlink et al Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity".	Oxygen	102-108	myosin heavy chain 14	Homo sapiens	45-51
26578671-0	2015	Letter by Teerlink et al Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity".	Oxygen	102-108	myosin heavy chain 14	Homo sapiens	172-178
26194060-1	2015	Oxygen-requiring enzymes, such as Delta4-desaturase (dihydroceramide desaturase), sphingolipid Delta4-desaturase/C-4-hydroxylase, and fatty acid 2-hydroxylase are involved in ceramide synthesis.	Oxygen	0-6	delta 4-desaturase, sphingolipid 2	Homo sapiens	101-128
26433470-4	2016	Like EGF, hypoxia treatment (1% O2) was also associated with a significant reduction in the sensitivity of MDA-MB-468 cells to ATP (EC50 of 0.5 muM for normoxic cells versus EC50 of 5.8 muM for hypoxic cells).	Oxygen	32-34	epidermal growth factor	Homo sapiens	5-8
3308437-6	1987	Islet (pro)insulin biosynthesis, glucose oxidation, and oxygen uptake at 16.7 mM glucose were partially inhibited by IL-1.	Oxygen	56-62	interleukin 1 alpha	Homo sapiens	117-121
25799977-5	2016	Using microspectrofluorimetry and the patch-clamp technique, we showed that hypoxia (1 % O2 for 48 h) significantly increased stretch- and TRPV4-induced calcium responses.	Oxygen	89-91	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	139-144
26402255-0	2015	Molecular Oxygen Induced in-Gap States in PbS Quantum Dots.	Oxygen	10-16	regenerating family member 3 alpha	Homo sapiens	25-31
3115154-6	1987	Circulatory oxygen transport resembled that at sea level.	Oxygen	12-18	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
26234616-0	2015	Seasonal oxygen depletion in the North Sea, a review.	Oxygen	9-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
26234616-6	2015	Mean oxygen consumption reflected a minimum seasonal turnover of 3.1 g N/m(2) in the south-eastern North Sea, including denitrification of 1 g N/m(2).	Oxygen	5-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
26253702-6	2015	In the current study, we showed that adenovirus-mediated Bif-1-overexpression promoted oxygen and glucose deprivation followed by reperfusion (OGD/R)-treated cortical neurons" survival and reduced the cell apoptotic rate.	Oxygen	87-93	SH3 domain containing GRB2 like, endophilin B1	Homo sapiens	57-62
29795790-7	2016	Together with thioredoxin (Trx), it catalyzes reduction of selenite and selenocystine by NADPH generating selenide which in the presence of oxygen redox cycles producing reactive oxygen species.	Oxygen	140-146	thioredoxin	Homo sapiens	14-25
29795790-7	2016	Together with thioredoxin (Trx), it catalyzes reduction of selenite and selenocystine by NADPH generating selenide which in the presence of oxygen redox cycles producing reactive oxygen species.	Oxygen	140-146	thioredoxin	Homo sapiens	27-30
26362945-1	2016	An alcohol dehydrogenase, AdhC, is required for Haemophilus influenzae Rd KW20 growth with high oxygen.	Oxygen	96-102	S-(hydroxymethyl)glutathione dehydrogenase	Haemophilus influenzae Rd KW20	26-30
3312952-4	1987	The RAD4 and RAD14 genes have a particular role in repair following exposure to those ethylating agents that preferentially alkylate oxygen, but not to those that preferentially ethylate nitrogen.	Oxygen	133-139	DNA repair protein RAD14	Saccharomyces cerevisiae S288C	13-18
26935092-7	2016	In order to improve dye photostablity, we focused on the effect of singlet oxygen ((1)O2) generated by excited PAI probes on probe degeneration, and developed a triplet-state quencher conjugated dye probe, IC-5-T.	Oxygen	83-88	serpin family E member 1	Homo sapiens	111-114
26322377-4	2015	Using docking, molecular dynamics (MD), and hybrid quantum mechanical/molecular mechanics methods, we have investigated mechanisms by which methionyl-tRNA synthetase (MetRS) may edit against the highly toxic, noncognate, amino acids homocysteine (Hcy) and its oxygen analogue, homoserine (Hse).	Oxygen	260-266	methionyl-tRNA synthetase 1	Homo sapiens	140-165
26322377-4	2015	Using docking, molecular dynamics (MD), and hybrid quantum mechanical/molecular mechanics methods, we have investigated mechanisms by which methionyl-tRNA synthetase (MetRS) may edit against the highly toxic, noncognate, amino acids homocysteine (Hcy) and its oxygen analogue, homoserine (Hse).	Oxygen	260-266	methionyl-tRNA synthetase 1	Homo sapiens	167-172
3624124-3	1987	At rest, mean (+/- SD) transdiaphragmatic pressure (Pdi) was lower inspiring 30% O2 compared with air (23 +/- 4 vs. 26 +/- 7 cmH2O, P less than 0.05), but the pattern of Ppl and Pga contraction was identical while breathing either gas mixture.	Oxygen	81-83	peptidyl arginine deiminase 1	Homo sapiens	52-55
26519878-7	2015	Furthermore, miR-494 overexpression suppressed basal oxygen consumption rate concomitant with the inhibition of myotube formation and without significant effects on the mitochondrial content.	Oxygen	53-59	microRNA 494	Homo sapiens	13-20
3624124-5	1987	During exercise, Pdi increased similarly while breathing air or 30% O2, but the latter was associated with a significant increase in peak inspiratory Pga and decreases in peak inspiratory Ppl and expiratory Pga.	Oxygen	68-70	peptidyl arginine deiminase 1	Homo sapiens	17-20
26240993-7	2015	Postmortem analysis showed significant increase in the expression of mitochondrial Cox4i2, the terminal enzyme of the mitochondrial respiratory chain and oxygen response element.	Oxygen	154-160	cytochrome c oxidase subunit 4I2	Mus musculus	83-89
3607211-0	1987	The effect of myoglobin-facilitated oxygen transport on the basal metabolism of papillary muscle.	Oxygen	36-42	myoglobin	Homo sapiens	14-23
26235421-2	2015	In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased oxygen consumption and energy expenditure.	Oxygen	171-177	iodothyronine deiodinase 2	Homo sapiens	63-94
26044841-11	2015	Intracellular generation of oxygen-derived free radicals in HVEC maintained in in-vitro culture was lower in the serum samples collected after treatment with SUL: 3.09+-0.35 abs/mug protein vs. 3.63+-0.32 abs/mug protein, at the start, P&lt;0.05.	Oxygen	28-34	nectin cell adhesion molecule 1	Homo sapiens	60-64
26349058-5	2015	EPO, CEPO and pHBSP enhanced scratch closure only at lower oxygen (5%), while their effect at atmospheric oxygen (21%) was not significant.	Oxygen	59-65	erythropoietin	Bos taurus	0-3
26572229-2	2015	The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor (HIF)-1beta, is part of the HIF pathway which mediates cellular adaptations to oxygen deprivation and facilitates tumour progression.	Oxygen	203-209	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	25-71
26572229-2	2015	The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor (HIF)-1beta, is part of the HIF pathway which mediates cellular adaptations to oxygen deprivation and facilitates tumour progression.	Oxygen	203-209	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	73-77
26572229-2	2015	The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor (HIF)-1beta, is part of the HIF pathway which mediates cellular adaptations to oxygen deprivation and facilitates tumour progression.	Oxygen	203-209	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	99-135
26392741-11	2015	CONCLUSIONS: Recently, we reported that nuclear beta-catenin, but not HIF-2alpha, regulates the expression of fibronectin and alpha-SMA in atmospheric oxygen.	Oxygen	151-157	catenin beta 1	Homo sapiens	48-60
26240367-3	2015	To test whether EDNRB plays a critical role in hypoxia tolerance and adaptation, we generated EdnrB knockout mice and found that when EdnrB (-/+) heterozygote mice are treated with lower levels of oxygen (O2), they tolerate various levels of hypoxia (even extreme hypoxia, e.g., 5% O2) very well.	Oxygen	197-203	endothelin receptor type B	Mus musculus	16-21
26243880-3	2015	Using a mouse model of oxygen-induced proliferative retinopathy, we showed that RORalpha expression was significantly increased and genetic deficiency of RORalpha substantially suppressed pathologic retinal neovascularization.	Oxygen	23-29	RAR-related orphan receptor alpha	Mus musculus	80-88
26243880-3	2015	Using a mouse model of oxygen-induced proliferative retinopathy, we showed that RORalpha expression was significantly increased and genetic deficiency of RORalpha substantially suppressed pathologic retinal neovascularization.	Oxygen	23-29	RAR-related orphan receptor alpha	Mus musculus	154-162
3607211-2	1987	The model partitions total oxygen flux into its simple and myoglobin-facilitated components.	Oxygen	27-33	myoglobin	Homo sapiens	59-68
26243880-7	2015	Moreover, treatment with a RORalpha inverse agonist SR1001 effectively protected against pathologic neovascularization in both oxygen-induced retinopathy and another angiogenic model of very-low-density lipoprotein receptor (Vldlr)-deficient (Vldlr (-/-) ) mice with spontaneous subretinal neovascularization, whereas a RORalpha agonist worsened oxygen-induced retinopathy.	Oxygen	127-133	RAR-related orphan receptor alpha	Mus musculus	27-35
26243880-7	2015	Moreover, treatment with a RORalpha inverse agonist SR1001 effectively protected against pathologic neovascularization in both oxygen-induced retinopathy and another angiogenic model of very-low-density lipoprotein receptor (Vldlr)-deficient (Vldlr (-/-) ) mice with spontaneous subretinal neovascularization, whereas a RORalpha agonist worsened oxygen-induced retinopathy.	Oxygen	346-352	RAR-related orphan receptor alpha	Mus musculus	27-35
26215374-4	2015	The effect of classical activators (lipopolysaccharide, LPS; interferon-gamma, IFN-gamma) was further potentiated with hypoxic (5% O2) conditions.	Oxygen	131-133	interferon regulatory factor 6	Homo sapiens	56-59
3607211-3	1987	The model includes variable sigmoidal, exponential, or hyperbolic functions relating oxygen partial pressure to both fractional myoglobin saturation and rate of oxygen consumption.	Oxygen	85-91	myoglobin	Homo sapiens	128-137
3607211-5	1987	Facilitation of oxygen transport by myoglobin was considerable as indexed both by the elevation of oxygen partial pressure on the longitudinal axis of the muscle and by the fraction of total oxygen flux at the muscle center contributed by oxymyoglobin.	Oxygen	16-22	myoglobin	Homo sapiens	36-45
3607211-5	1987	Facilitation of oxygen transport by myoglobin was considerable as indexed both by the elevation of oxygen partial pressure on the longitudinal axis of the muscle and by the fraction of total oxygen flux at the muscle center contributed by oxymyoglobin.	Oxygen	99-105	myoglobin	Homo sapiens	36-45
3607211-5	1987	Facilitation of oxygen transport by myoglobin was considerable as indexed both by the elevation of oxygen partial pressure on the longitudinal axis of the muscle and by the fraction of total oxygen flux at the muscle center contributed by oxymyoglobin.	Oxygen	99-105	myoglobin	Homo sapiens	36-45
26050843-1	2015	Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1alpha (HIF-1alpha) has been shown to be a major regulator of the response to low oxygen.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	88-119
26230144-9	2015	Different singlet oxygen ((1)O2) quantum yields (PhiDelta = 75% and 70%) and triplet state quantum yields (PhiT = 91% and 69%, respectively) were observed for complexes Pt-1 and Pt-4.	Oxygen	26-31	zinc finger protein 77	Homo sapiens	169-173
26050843-1	2015	Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1alpha (HIF-1alpha) has been shown to be a major regulator of the response to low oxygen.	Oxygen	195-201	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	121-131
2822166-3	1987	Photochemical action spectra for the relief of CO-inhibited O2 uptake revealed contributions from both cytochrome b-245 and myeloperoxidase.	Oxygen	60-62	myeloperoxidase	Rattus norvegicus	124-139
26286733-9	2015	PAI-1 showed a significant positive correlation with the apnea-hypopnea index, percentage of time spent at O2 saturation &lt; 90%, and oxygen desaturation index, whereas TGF-beta was inversely related to all 3 of these parameters.	Oxygen	107-109	serpin family E member 1	Homo sapiens	0-5
26148512-2	2015	Under normal O2 tension, HIFalpha subunits are targeted for proteasomal degradation, mainly through vHL-dependent ubiquitylation.	Oxygen	13-15	endothelial PAS domain protein 1	Homo sapiens	25-33
3550869-2	1987	The oxygen enhancement ratio (OER) for SSB induction determined for cells irradiated in air versus irradiation of cells made hypoxic by metabolic depletion of O2 was 9.7.	Oxygen	4-10	lupus La protein	Cricetulus griseus	39-42
26098370-7	2015	The reaction requires molecular oxygen, which is activated by a di-iron centre, and cytochrome b5, which regenerates the di-iron centre.	Oxygen	32-38	cytochrome b5 type A	Homo sapiens	84-97
26950741-0	2015	Altitude Above Sea Level and Body Mass Index as Determinants of Oxygen Saturation in Children: The SON@ Study.	Oxygen	64-70	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	15-18
26950741-1	2015	BACKGROUND: Altitude above sea level and body mass index are well-recognized determinants of oxygen saturation in adult populations; however, the contribution of these factors to oxygen saturation in children is less clear.	Oxygen	93-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	27-30
26950741-10	2015	CONCLUSIONS: Altitude was the main determinant of oxygen saturation, which on average decreased 1.7% per km of elevation from a percentage of 98.7 at sea level.	Oxygen	50-56	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	150-153
26461813-5	2015	SUSD2(+) eMSC were cultured in SFM with bFGF/EGF in 5% O2/5% CO2.	Oxygen	55-57	epidermal growth factor	Homo sapiens	45-48
26356812-12	2015	Higher increases in respiration rates than in production may lead to the depletion of the oxygen pool, further aggravating hypoxia in the Baltic Sea.	Oxygen	90-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	145-148
26109375-5	2015	Explicit dependence of water polarizability on a distance between a water oxygen and Mg(2+) is derived from in vacuum MP2 calculations of Mg(2+)-water dimer.	Oxygen	74-80	tryptase pseudogene 1	Homo sapiens	118-121
26464622-8	2015	CONCLUSION: MSP and its receptor RON are involved in the smoke-induced airway inflammation in rats via promoting AM to release inflammatory cytokines and inducing the increase of oxygen free radical.	Oxygen	179-185	macrophage stimulating 1 receptor	Rattus norvegicus	33-36
3550869-2	1987	The oxygen enhancement ratio (OER) for SSB induction determined for cells irradiated in air versus irradiation of cells made hypoxic by metabolic depletion of O2 was 9.7.	Oxygen	159-161	lupus La protein	Cricetulus griseus	39-42
3593309-0	1987	Dependence of erythropoietin production on blood oxygen affinity and hemoglobin concentration in rats.	Oxygen	49-55	erythropoietin	Rattus norvegicus	14-28
25146847-0	2015	Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection Against Ischemic Stroke.	Oxygen	32-38	secreted phosphoprotein 1	Homo sapiens	0-11
26260787-3	2015	We show here that the FAD-dependent monooxygenase Coq6, which is known to hydroxylate position C5, also deaminates position C4 in a reaction implicating molecular oxygen, as demonstrated with labeling experiments.	Oxygen	40-46	putative N,N-dimethylaniline monooxygenase COQ6	Saccharomyces cerevisiae S288C	50-54
3806383-0	1987	Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity.	Oxygen	86-92	glutathione-disulfide reductase	Rattus norvegicus	24-45
23596131-6	2015	In turn, 10% O(2) promoted the highest CD34(+) CD90(+) cell expansion, reaching 22 +- 5.4- vs 5.6 +- 2.4- and 5.7 +- 2.0-fold for 2%, 5% and 21% O(2), respectively, after 14 days.	Oxygen	13-17	Thy-1 cell surface antigen	Homo sapiens	47-51
26159831-2	2015	It has previously been determined that oxygen regulates human embryonic stem (hES) cell glycolytic and amino acid metabolism, but the effects on mitochondria are as yet unknown.	Oxygen	39-45	ribosome binding protein 1	Homo sapiens	78-81
25572324-8	2015	Immunohistochemical expressions of oxidative stress marker 8-hydroxy-2"-deoxyguanosine and CTGF immunoreactivities were significantly higher in the rats reared in O2-enriched air compared with the rats reared in ambient air on Postnatal Days 7 and 21.	Oxygen	163-165	cellular communication network factor 2	Rattus norvegicus	91-95
26159831-4	2015	In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.	Oxygen	38-44	ribosome binding protein 1	Homo sapiens	59-62
3804908-1	1986	Multiday exposures of CD-1 mice to He-O2 atmospheres at pressures from 30 to 100 atm result in marked increases of threshold pressures for type I high-pressure neurological syndrome seizures.	Oxygen	38-40	CD1 antigen complex	Mus musculus	22-26
26159831-4	2015	In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.	Oxygen	38-44	peroxisome proliferator activated receptor alpha	Homo sapiens	167-172
26159831-4	2015	In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.	Oxygen	38-44	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	177-183
26159831-5	2015	Furthermore, MEL2 hES cell glucose consumption, lactate production and amino acid turnover were elevated under physiological oxygen.	Oxygen	125-131	ribosome binding protein 1	Homo sapiens	18-21
26159831-8	2015	Here we report the first incidence of metabolic dysfunction in a hES cell population, defined as a failure to respond to oxygen concentration through the modulation of metabolism, demonstrating that hES cells can be perturbed during culture despite exhibiting the defining characteristics of pluripotent cells.	Oxygen	121-127	ribosome binding protein 1	Homo sapiens	65-68
26159831-9	2015	Collectively, these data reveal a central role for oxygen in the regulation of hES cell metabolism and mitochondrial function, whereby physiological oxygen promotes glucose flux and suppresses mitochondrial biogenesis and gene expression.	Oxygen	51-57	ribosome binding protein 1	Homo sapiens	79-82
26159831-9	2015	Collectively, these data reveal a central role for oxygen in the regulation of hES cell metabolism and mitochondrial function, whereby physiological oxygen promotes glucose flux and suppresses mitochondrial biogenesis and gene expression.	Oxygen	149-155	ribosome binding protein 1	Homo sapiens	79-82
25967673-10	2015	ATM more likely carries out its canonical response to nuclear DNA damage and may function to attenuate mitochondrial ROS that contribute to oxygen toxicity.	Oxygen	140-146	ATM serine/threonine kinase	Homo sapiens	0-3
26144862-0	2015	Mechanism of Oxygen Activation in a Flavin-Dependent Monooxygenase: A Nearly Barrierless Formation of C4a-Hydroperoxyflavin via Proton-Coupled Electron Transfer.	Oxygen	13-19	complement C4A (Rodgers blood group)	Homo sapiens	102-105
26144862-5	2015	Notably, density functional calculations indicated that the formation of C4aOOH is nearly barrierless, possibly facilitated by the active site arrangement in which His396 positions the proximal oxygen of the ( )OOH in an optimum position to directly attack the C4a atom of the isoalloxazine ring.	Oxygen	194-200	complement C4A (Rodgers blood group)	Homo sapiens	73-76
2430004-11	1986	Because oxygen metabolites generated by the FMN are mediators of inflammation and hypersensitivity, direct inhibition of PMN activation as well as potentiation of catecholamine activity may be important therapeutic effects of theophylline and enprofylline.	Oxygen	8-14	formin 1	Homo sapiens	44-47
26374840-6	2015	We found that miR-150 was highly expressed in normal quiescent retinal blood vessels and significantly suppressed in pathologic neovessels in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	159-165	microRNA 150	Mus musculus	14-21
2876100-3	1986	Masking of the 8-oxygen function, as in 6 and 8, dramatically reduced mouse hot-plate activity, as did its loss (9).	Oxygen	17-23	alcohol dehydrogenase, iron containing, 1	Mus musculus	76-79
26396267-3	2015	We found that Socs3 expression was increased in the retinal ganglion cell and inner nuclear layers after oxygen-induced retinopathy.	Oxygen	105-111	suppressor of cytokine signaling 3	Mus musculus	14-19
26396267-4	2015	Mice with Socs3 deficiency in neuronal and glial cells had substantially reduced vaso-obliterated retinal areas and increased pathological retinal neovascularization in response to oxygen-induced retinopathy, suggesting that loss of neuronal/glial SOCS3 increased both retinal vascular regrowth and pathological neovascularization.	Oxygen	181-187	suppressor of cytokine signaling 3	Mus musculus	10-15
26324945-0	2015	Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 1	Mus musculus	32-36
26356605-3	2015	COUP-TFII represses genes critical for mitochondrial electron transport chain enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased levels of reactive oxygen species and lower rates of oxygen consumption in mitochondria.	Oxygen	197-203	nuclear receptor subfamily 2, group F, member 2	Mus musculus	0-9
26622413-1	2015	The endothelial PAS domain protein 1 (EPAS1) gene functions to sense the blood oxygen level by regulating the hypoxia-inducible transcription factor pathway, and single nucleotide polymorphisms (SNPs) of EPAS1 have been found to have a strong and positive selection in the adaptation of the native Tibetan highland population to high-altitude hypoxia.	Oxygen	79-85	endothelial PAS domain protein 1	Homo sapiens	4-36
26622413-1	2015	The endothelial PAS domain protein 1 (EPAS1) gene functions to sense the blood oxygen level by regulating the hypoxia-inducible transcription factor pathway, and single nucleotide polymorphisms (SNPs) of EPAS1 have been found to have a strong and positive selection in the adaptation of the native Tibetan highland population to high-altitude hypoxia.	Oxygen	79-85	endothelial PAS domain protein 1	Homo sapiens	38-43
25809453-4	2015	To evaluate his HTx candidacy, oxygen inhalation test was applied during right heart catheterization (RHC) and PVR was drastically decreased to 2.29 WU.	Oxygen	31-37	PVR cell adhesion molecule	Homo sapiens	111-114
26111938-9	2015	Existing evidence suggests that Abeta peptides-induced up-regulation of expression and activity of NADPH oxidase causes increased production of superoxide anion (.O2(-)).	Oxygen	163-165	amyloid beta (A4) precursor protein	Mus musculus	32-37
26111938-11	2015	Elevation of .O2(-) and H2O2 might cause oxidation of tetrahydrobiopterin (BH4) to dihydrobiopterin (BH2) and subsequent uncoupling of endothelial nitric oxide synthase (eNOS) (a) thus reducing levels of nitric oxide (NO) and 3",5"-cyclic guanosine monophosphate (cGMP).	Oxygen	14-16	nitric oxide synthase 3, endothelial cell	Mus musculus	135-168
26111938-11	2015	Elevation of .O2(-) and H2O2 might cause oxidation of tetrahydrobiopterin (BH4) to dihydrobiopterin (BH2) and subsequent uncoupling of endothelial nitric oxide synthase (eNOS) (a) thus reducing levels of nitric oxide (NO) and 3",5"-cyclic guanosine monophosphate (cGMP).	Oxygen	14-16	nitric oxide synthase 3, endothelial cell	Mus musculus	170-174
26111938-12	2015	Supplementation of BH4 or activation of PPARdelta prevents detrimental effects of eNOS uncoupling by restoring bioavailability of BH4 and scavenging of .O2(-), respectively (b).	Oxygen	153-155	nitric oxide synthase 3, endothelial cell	Mus musculus	82-86
25736363-9	2015	RESULTS: ENO1 gene expression was remarkably upregulated, as well as its translation into protein, in RA-FLSs and OA-FLSs that were cultured in 3% O2 concentration.	Oxygen	147-149	enolase 1	Homo sapiens	9-13
26119225-0	2015	NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure.	Oxygen	56-62	NLR family, pyrin domain containing 3	Mus musculus	0-5
26119225-7	2015	Together, our results indicate that NLRP3 inflammasome activation induced by mitochondrial reactive oxygen species plays a key role in mediating paraquat-induced long-term cognition decline by elevating brain inflammation.	Oxygen	100-106	NLR family, pyrin domain containing 3	Mus musculus	36-41
26227505-2	2015	Hsp90 is induced when a cell undergoes various types of environmental stresses such as heat, cold, or oxygen deprivation.	Oxygen	102-108	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
26361671-1	2015	INTRODUCTION: This study aimed to determine whether a controlled portal blood arterialization by a liver extracorporeal device (L.E.O2 NARDO) is effective in treating acute hepatic failure (AHF) induced in swine by carbon tetrachloride (CCl4) administration.	Oxygen	132-134	C-C motif chemokine 4	Sus scrofa	237-241
26347655-9	2015	Using our functional CcO model, we have demonstrated that at the same concentration range H2S can reversibly inhibit catalytic oxygen reduction.	Oxygen	127-133	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	90-93
26047733-3	2015	In the current investigation we studied the MB-induced neuroprotective mechanism focusing on stabilization and activation of hypoxia-inducible factor-1alpha (HIF-1alpha) in an in vitro oxygen and glucose deprivation (OGD)-reoxygenation model.	Oxygen	185-191	hypoxia inducible factor 1, alpha subunit	Mus musculus	125-156
26047733-3	2015	In the current investigation we studied the MB-induced neuroprotective mechanism focusing on stabilization and activation of hypoxia-inducible factor-1alpha (HIF-1alpha) in an in vitro oxygen and glucose deprivation (OGD)-reoxygenation model.	Oxygen	185-191	hypoxia inducible factor 1, alpha subunit	Mus musculus	158-168
26249166-0	2015	CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity.	Oxygen	102-108	5' nucleotidase, ecto	Mus musculus	0-4
26049000-9	2015	Lastly we show using an oxygen electrode assay that plasma renalase activity is below the level of detection and only when exogenous renalase and 6-dihydroNAD are added can dioxygen be observed to be consumed.	Oxygen	24-30	renalase, FAD dependent amine oxidase	Homo sapiens	59-67
26622378-0	2015	Effect of hyperbaric oxygen preconditioning on peri-hemorrhagic focal edema and aquaporin-4 expression.	Oxygen	21-27	aquaporin 4	Rattus norvegicus	80-91
26622378-1	2015	The aim of the present study was to investigate the effect of hyperbaric oxygen preconditioning (HBO-PC) on peri-hemorrhagic focal edema and aquaporin-4 (AQP-4) expression in an experimental intracerebral hemorrhage (ICH) rat model.	Oxygen	73-79	aquaporin 4	Rattus norvegicus	141-152
25494391-7	2015	The iron needed for hemoglobin synthesis is ensured by inhibiting hepcidin to increase ferroportin activity and iron availability and hence to make certain that efficient blood oxygen transport occurs for aerobic exercise.	Oxygen	177-183	hepcidin antimicrobial peptide	Homo sapiens	66-74
26181205-5	2015	3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR) produces isoprenoids, and is posttranslationally regulated by oxygen.	Oxygen	118-124	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-48
26181205-5	2015	3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR) produces isoprenoids, and is posttranslationally regulated by oxygen.	Oxygen	118-124	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	50-54
25864421-2	2015	The development of a robust and versatile Rh(ii)/Zr(iv)-BINOL co-catalytic system not only gives high diastereo- and enantioselective controls of the three-component reaction, but also shows excellent functionality tolerances that allow a wide range of functionalities to be pre-installed in each component and readily undergo one-pot subsequent cyclization reactions, thus providing rapid and diversity-oriented synthesis (DOS) of different types of chiral nitrogen- and/or oxygen-containing polyfunctional heterocycles.	Oxygen	475-481	Rh blood group D antigen	Homo sapiens	42-48
25377427-6	2015	At P3, P6, P8, and P12, uncoupled mitochondrial oxygen consumption rate, determined by Seahorse 24 XF Analyzer, as higher in AZT/ddI-exposed PGC-1alpha cells, compared to AZT/ddI-exposed control cells (p &lt; 0.05 at all P).	Oxygen	48-54	PPARG coactivator 1 alpha	Sus scrofa	141-151
25663339-5	2015	Dissolved oxygen (DO) in the water reduced the 2,4-DNT degradation and the formation of 2,4-DAT.	Oxygen	10-16	5', 3'-nucleotidase, cytosolic	Homo sapiens	51-54
26079803-4	2015	Knock-out of the main oxygen sensing molecule, hypoxia-inducible factor-1alpha (Hif-1alpha), had no impact on Wnt activation assuming that physioxia induces the Wnt pathway independently of Hif-1alpha.	Oxygen	22-28	hypoxia inducible factor 1, alpha subunit	Mus musculus	47-78
26039220-7	2015	Conversely, aerobic surface colonies of the HBR1 heterozygote on Spider and GlcNAc media lacked filamentation that could be rescued by growth under low (5%) O2.	Oxygen	157-159	nuclear receptor subfamily 4, group A, member 1	Mus musculus	44-48
25929654-6	2015	Cox6b1-3T3 cells showed increased oxygen consumption rates, Cox activity, and intracellular ATP concentrations, indicating enhanced mitochondrial respiration, compared with Con-3T3 cells.	Oxygen	34-40	cytochrome c oxidase, subunit 6B1	Mus musculus	0-6
25953669-11	2015	Indirect calorimetry showed, at 10 weeks of feeding HFHS diet, significantly increased oxygen consumption (VO2) in PAPP-A KO mice fed HFHS diet compared to normal mice fed the same diet.	Oxygen	87-93	pregnancy-associated plasma protein A	Mus musculus	115-121
26149214-1	2015	Activating transcription factor 1 (ATF1) may be involved in essential hypertension (EH) by induction of NADPH oxidase 1 (NOX1) and radical oxygen species (ROSs) production.	Oxygen	139-145	activating transcription factor 1	Homo sapiens	0-33
26149214-1	2015	Activating transcription factor 1 (ATF1) may be involved in essential hypertension (EH) by induction of NADPH oxidase 1 (NOX1) and radical oxygen species (ROSs) production.	Oxygen	139-145	activating transcription factor 1	Homo sapiens	35-39
26258123-3	2015	Central to the molecular mechanisms underlying O2 homeostasis are the hypoxia-inducible factors-1 and -2 alpha (HIF-1alpha and EPAS1/HIF-2alpha) that function as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	endothelial PAS domain protein 1	Homo sapiens	70-110
26258123-3	2015	Central to the molecular mechanisms underlying O2 homeostasis are the hypoxia-inducible factors-1 and -2 alpha (HIF-1alpha and EPAS1/HIF-2alpha) that function as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	endothelial PAS domain protein 1	Homo sapiens	127-132
26258123-3	2015	Central to the molecular mechanisms underlying O2 homeostasis are the hypoxia-inducible factors-1 and -2 alpha (HIF-1alpha and EPAS1/HIF-2alpha) that function as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	endothelial PAS domain protein 1	Homo sapiens	133-143
26007655-3	2015	We used chromatin immunoprecipitation (ChIP), gene editing (TALEN) and chromosome conformation capture (3C) to localize and functionally characterize a 82 kb upstream HRE that solely drives oxygen-regulated expression of the newly identified HIF target gene PAG1.	Oxygen	190-196	phosphoprotein associated with glycosphingolipid microdomains 1	Mus musculus	258-262
25881895-0	2015	Bumetanide-induced NKCC1 inhibition attenuates oxygen-glucose deprivation-induced decrease in proliferative activity and cell cycle progression arrest in cultured OPCs via p-38 MAPKs.	Oxygen	47-53	solute carrier family 12 member 2	Homo sapiens	19-24
26098368-4	2015	Here we report fate mapping of hypoxic cells and their progenies by generating a transgenic mouse expressing a chimaeric protein in which the oxygen-dependent degradation (ODD) domain of Hif-1alpha is fused to the tamoxifen-inducible CreERT2 recombinase.	Oxygen	142-148	hypoxia inducible factor 1, alpha subunit	Mus musculus	187-197
25764979-11	2015	Downregulation of MIC26 induced a decrease in mitochondrial oxygen consumption, whereas mitochondrial network morphology and ROS levels remained unaffected.	Oxygen	60-66	apolipoprotein O	Homo sapiens	18-23
27180350-7	2015	after introducing into the hypoxic environment (hypoxic tent), imitating atmospheric air with oxygen concentration corresponding to 3200 m above sea level.	Oxygen	94-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	145-148
26198952-3	2015	The cells transfected with SphK1 siRNA and with a negative control siRNA were then exposed to 3% oxygen or 150 micromol/L CoCl2 to induce hypoxia.	Oxygen	97-103	sphingosine kinase 1	Homo sapiens	27-32
3019355-9	1986	This ability of the bipyridyls to generate active oxygen was positively correlated with the ability to induce toxicity in hepatocytes pretreated with 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) to inhibit their glutathione reductase activity, i.e. DQ greater than BV greater than PQ.	Oxygen	50-56	glutathione-disulfide reductase	Rattus norvegicus	212-233
25979862-8	2015	The present study provided the first evidence of a shift of the hMSC cytokine signature induced by oxygen tension, particularly near anoxia (0.1% O2).	Oxygen	99-105	musculin	Homo sapiens	64-68
25979862-8	2015	The present study provided the first evidence of a shift of the hMSC cytokine signature induced by oxygen tension, particularly near anoxia (0.1% O2).	Oxygen	146-148	musculin	Homo sapiens	64-68
25913075-9	2015	In conclusion, a constitutively higher level of VEGF expression associated with retinal development protects GTPCH-deficient neonates from oxygen-induced vascular damage.	Oxygen	139-145	GTP cyclohydrolase 1	Mus musculus	109-114
3769053-6	1986	While the oxygen-containing coumaran and benzofuran both increased the NADH: quinone reductase activity in hepatic cytosol, the nitrogen-containing indole and indole-3-carbinol did not.	Oxygen	10-16	crystallin, zeta	Mus musculus	77-94
26246998-4	2015	The mechanism for detection is rationalized by the nucleophilic substitution of the phenolic oxygen atom at the indoline C-2 atom by the cyanide anion to form a stable indolylnitrile adduct and to generate the colored 4-nitrophenolate chromophore.	Oxygen	93-99	complement C2	Homo sapiens	121-124
26016690-6	2015	Renalase serves to rapidly oxidize these isomers to form beta-NAD(P)+ and then pass the electrons to dioxygen, forming H2O2.	Oxygen	101-109	renalase, FAD dependent amine oxidase	Homo sapiens	0-8
2874262-5	1986	A monooxygenase-like enzymatic activity of D-amino acid oxidase with these novel substrates is considered, for which the final products are hypothesized to be protein alpha-carbon hydroxyls resulting from the incorporation of one atom of oxygen into the substrate, the other being reduced to water.	Oxygen	6-12	D-amino acid oxidase	Homo sapiens	43-63
28626720-5	2015	In contrast, the GPD2 promoter was found to be inactive when cells were cultivated in continuous mode at a growth rate of 0.3 h-1 and in conditions with excess oxygen (i.e. with an aeration of 2.5 vvm, and a stirring of 800 rpm).	Oxygen	160-166	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	17-21
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	26-32	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	102-107
26261584-11	2015	ER stress UPR pathway protein, cleaved ATF6, was increased significantly when treated with 0.1% O2 compared with the cells treated with 20% O2.	Oxygen	96-98	activating transcription factor 6	Homo sapiens	39-43
26261584-11	2015	ER stress UPR pathway protein, cleaved ATF6, was increased significantly when treated with 0.1% O2 compared with the cells treated with 20% O2.	Oxygen	140-142	activating transcription factor 6	Homo sapiens	39-43
25578474-5	2015	We demonstrate in mice with HSC-specific conditional deletion of the Hif1a gene that the oxygen-labile transcription factor HIF-1alpha is essential for HSC mobilization in response to G-CSF and Plerixafor.	Oxygen	89-95	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-74
25578474-5	2015	We demonstrate in mice with HSC-specific conditional deletion of the Hif1a gene that the oxygen-labile transcription factor HIF-1alpha is essential for HSC mobilization in response to G-CSF and Plerixafor.	Oxygen	89-95	hypoxia inducible factor 1, alpha subunit	Mus musculus	124-134
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	217-223	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	102-107
25849727-5	2015	The NADPH oxidase (NOX)/dual oxidase (DUOX) family is a major enzymatic source of intracellular reactive oxygen, and we show that GnRH stimulation of mouse primary pituitary cells and the LbetaT2 gonadotrope cell line elevates intracellular reactive oxygen via NOX/DUOX activity.	Oxygen	105-111	gonadotropin releasing hormone 1	Mus musculus	130-134
25849727-5	2015	The NADPH oxidase (NOX)/dual oxidase (DUOX) family is a major enzymatic source of intracellular reactive oxygen, and we show that GnRH stimulation of mouse primary pituitary cells and the LbetaT2 gonadotrope cell line elevates intracellular reactive oxygen via NOX/DUOX activity.	Oxygen	250-256	gonadotropin releasing hormone 1	Mus musculus	130-134
25849727-11	2015	These results indicate that reactive oxygen is a potent signaling intermediate produced in response to GnRH stimulation and further suggest that reactive oxygen derived from other sources may influence the gonadotrope response to GnRH stimulation.	Oxygen	37-43	gonadotropin releasing hormone 1	Mus musculus	103-107
25849727-11	2015	These results indicate that reactive oxygen is a potent signaling intermediate produced in response to GnRH stimulation and further suggest that reactive oxygen derived from other sources may influence the gonadotrope response to GnRH stimulation.	Oxygen	37-43	gonadotropin releasing hormone 1	Mus musculus	230-234
25849727-11	2015	These results indicate that reactive oxygen is a potent signaling intermediate produced in response to GnRH stimulation and further suggest that reactive oxygen derived from other sources may influence the gonadotrope response to GnRH stimulation.	Oxygen	154-160	gonadotropin releasing hormone 1	Mus musculus	103-107
25849727-11	2015	These results indicate that reactive oxygen is a potent signaling intermediate produced in response to GnRH stimulation and further suggest that reactive oxygen derived from other sources may influence the gonadotrope response to GnRH stimulation.	Oxygen	154-160	gonadotropin releasing hormone 1	Mus musculus	230-234
25292361-6	2015	(1)O2 activates a signalling pathway that depends on the two EXECUTER (EX) proteins EX1 and EX2 and triggers a programmed cell death response.	Oxygen	0-5	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	92-95
26002039-10	2015	After AtT-20 cells were cultured in 1 % O2 and then treated with dexamethasone, HIF-1alpha levels significantly increased or decreased in normoxic or hypoxic conditions, respectively.	Oxygen	40-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	80-90
3719069-9	1986	For a myoglobin-rich muscle fiber (0.5 mM myoglobin), the model predicts that maximal oxygen consumption can proceed with a relatively flat (less than 5 mm Hg) oxygen tension drop from fiber periphery to core over a large range for diffusion coefficients.	Oxygen	86-92	myoglobin	Homo sapiens	6-15
25750127-6	2015	Introduction of a single oxygen atom change into polySia by exogenous feeding of the non-neural sialic acid Neu5Gc (N-glycolylneuraminic acid) caused resistance to Neu1-induced polySia turnover and also inhibited the associated release of brain-derived neurotrophic factor.	Oxygen	25-31	brain derived neurotrophic factor	Mus musculus	239-272
25808318-5	2015	HEK cells overexpressing MT-2A demonstrated reduced oxygen consumption and lower cellular ATP levels.	Oxygen	52-58	metallothionein 2A	Homo sapiens	25-30
3719069-9	1986	For a myoglobin-rich muscle fiber (0.5 mM myoglobin), the model predicts that maximal oxygen consumption can proceed with a relatively flat (less than 5 mm Hg) oxygen tension drop from fiber periphery to core over a large range for diffusion coefficients.	Oxygen	86-92	myoglobin	Homo sapiens	42-51
3719069-9	1986	For a myoglobin-rich muscle fiber (0.5 mM myoglobin), the model predicts that maximal oxygen consumption can proceed with a relatively flat (less than 5 mm Hg) oxygen tension drop from fiber periphery to core over a large range for diffusion coefficients.	Oxygen	160-166	myoglobin	Homo sapiens	6-15
3719069-9	1986	For a myoglobin-rich muscle fiber (0.5 mM myoglobin), the model predicts that maximal oxygen consumption can proceed with a relatively flat (less than 5 mm Hg) oxygen tension drop from fiber periphery to core over a large range for diffusion coefficients.	Oxygen	160-166	myoglobin	Homo sapiens	42-51
3539588-3	1986	Fairly good electrostatic complementarities were found for the oxygen atoms of P1 and P2 amide, and for the hydrogen atom of P2 amide.	Oxygen	63-69	perforin 1	Rattus norvegicus	79-88
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	268-276
25866315-1	2015	A multifunctional phosphorescent iridium(III) complex (Ir1) for specific nucleus staining was synthesized and applied for monitoring the intranuclear oxygen level.	Oxygen	150-156	nischarin	Homo sapiens	55-58
25978564-11	2015	Possibly, CRNDEP also participates in oxygen metabolism, considering our in silico results, and the correlation between its enforced overexpression and the formation of stress granules.	Oxygen	38-44	colorectal neoplasia differentially expressed	Homo sapiens	10-16
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	4-33
25974097-1	2015	The myeloid translocation gene 16 (MTG16) co-repressor down regulates expression of multiple glycolytic genes, which are targets of the hypoxia-inducible factor 1 (HIF1) heterodimer transcription factor that is composed of oxygen-regulated labile HIF1alpha and stable HIF1beta subunits.	Oxygen	223-229	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	35-40
3943788-11	1986	Rapid recovery to initial O2 consumption rates occurred with time as CCl4 evaporated from the incubation system.	Oxygen	26-28	C-C motif chemokine ligand 4	Homo sapiens	69-73
25532443-3	2015	We examined blood oxygen level dependent (BOLD) response to an fMRI-based cognitive task designed to assess response inhibition (Go/NoGo) and past month risk behavior (number of substance use days; number of unprotected sex days).	Oxygen	18-24	reticulon 4	Homo sapiens	132-136
25865244-3	2015	The diiron center of human DOHH (hDOHH) forms a peroxo-diiron(III) intermediate (hDOHHperoxo) when its reduced form reacts with O2.	Oxygen	128-130	deoxyhypusine hydroxylase	Homo sapiens	27-31
25865244-3	2015	The diiron center of human DOHH (hDOHH) forms a peroxo-diiron(III) intermediate (hDOHHperoxo) when its reduced form reacts with O2.	Oxygen	128-130	deoxyhypusine hydroxylase	Homo sapiens	33-38
25394489-10	2015	Mechanistically, suppression of Bnip3 following PTEN loss is likely due to reduction of hypoxia-inducible factor-2alpha (HIF-2alpha) because forced expression of an oxygen-stable HIF-2alpha mutant rescues Bnip3 expression and apoptosis.	Oxygen	165-171	endothelial PAS domain protein 1	Mus musculus	88-119
25796334-6	2015	In an oxygen-induced retinopathy (OIR) mouse model, immunohistochemistry showed significantly increased ERRgamma expression in the ganglion cell layer at postnatal day (P) 17.	Oxygen	6-12	estrogen-related receptor gamma	Mus musculus	104-112
25796334-7	2015	In a ganglion cell line (RGC-5), mRNA and protein levels of ERRgamma were increased by desferrioxamine treatment and hypoxic conditions (1% O2).	Oxygen	140-142	estrogen-related receptor gamma	Mus musculus	60-68
25660488-4	2015	The complexes, Cu(HL1)2 and Cu(HL2)2 0.5H2O, have flat square geometry with oxygen atoms in the first coordination sphere.	Oxygen	76-82	intelectin 1	Homo sapiens	18-21
25394489-10	2015	Mechanistically, suppression of Bnip3 following PTEN loss is likely due to reduction of hypoxia-inducible factor-2alpha (HIF-2alpha) because forced expression of an oxygen-stable HIF-2alpha mutant rescues Bnip3 expression and apoptosis.	Oxygen	165-171	endothelial PAS domain protein 1	Mus musculus	121-131
25394489-10	2015	Mechanistically, suppression of Bnip3 following PTEN loss is likely due to reduction of hypoxia-inducible factor-2alpha (HIF-2alpha) because forced expression of an oxygen-stable HIF-2alpha mutant rescues Bnip3 expression and apoptosis.	Oxygen	165-171	endothelial PAS domain protein 1	Mus musculus	179-189
25686096-11	2015	Considering the function of CYGB as O2 carrier, these results strongly support the hypothesis that HSCs are involved in the CYP2E1-mediated xenobiotic activation by augmenting O2 supply to hepatocytes.	Oxygen	36-38	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
25686096-12	2015	In conclusion, CYGB in HSCs contributes to the CYP-mediated metabolism of xenobiotics in hepatocytes by supplying O2 for enzymatic oxidation.	Oxygen	114-116	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	47-50
25594800-8	2015	It also fits the oxygen dissociation curve influenced by simultaneous changes in H+, CO2and O2, which makes it a strong candidate for integration into more complex models of blood acid-base with gas transport, where any combination of mentioned substances can appear.	Oxygen	17-23	complement C2	Homo sapiens	85-94
25919031-9	2014	These changes were at least partly ensured by the increased concentration of MCP-1 and IL-8 at 5% O2.	Oxygen	98-100	C-C motif chemokine ligand 2	Homo sapiens	77-82
3943788-13	1986	A portion of this recovery could be inhibited by SKF 525A, suggesting that some O2 consumption was due to CCl4 metabolism and ensuing lipid peroxidation.	Oxygen	80-82	C-C motif chemokine ligand 4	Homo sapiens	106-110
3484471-4	1986	The glutathione synthetase deficient cells have a reduced oxygen enhancement ratio (1.5) compared to control cells (2.7).	Oxygen	58-64	glutathione synthetase	Homo sapiens	4-26
25900831-2	2015	O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-gamma-lyase (CSE).	Oxygen	0-2	heme oxygenase 2	Mus musculus	75-91
25900831-2	2015	O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-gamma-lyase (CSE).	Oxygen	0-2	heme oxygenase 2	Mus musculus	93-97
25900831-3	2015	We report that O2 stimulated the generation of CO, but not that of H2S, and required two cysteine residues in the heme regulatory motif (Cys(265) and Cys(282)) of HO-2.	Oxygen	15-17	heme oxygenase 2	Mus musculus	163-167
25900831-6	2015	In carotid bodies from mice lacking HO-2, compensatory increased abundance of nNOS (neuronal nitric oxide synthase) mediated O2 sensing through PKG-dependent regulation of H2S by nitric oxide.	Oxygen	125-127	heme oxygenase 2	Mus musculus	36-40
25852648-1	2015	Under obese conditions, adipose tissue can become oxygen-deficient or hypoxic.	Oxygen	50-56	WD and tetratricopeptide repeats 1	Mus musculus	24-31
25712221-0	2015	Catalytic activity of human indoleamine 2,3-dioxygenase (hIDO1) at low oxygen.	Oxygen	46-52	indoleamine 2,3-dioxygenase 1	Homo sapiens	57-62
25712221-3	2015	Here we report on enzyme kinetics and catalytic mechanism of hIDO1, studied at varied levels of dioxygen (O2) and L-tryptophan (L-Trp).	Oxygen	96-104	indoleamine 2,3-dioxygenase 1	Homo sapiens	61-66
3934271-3	1985	Both aerobic (oxygen consumption) and anaerobic (lactic acid production) metabolism of CTLL-2 cell are stimulated by rIL 2.	Oxygen	14-20	interleukin 2	Rattus norvegicus	117-122
25712221-3	2015	Here we report on enzyme kinetics and catalytic mechanism of hIDO1, studied at varied levels of dioxygen (O2) and L-tryptophan (L-Trp).	Oxygen	106-108	indoleamine 2,3-dioxygenase 1	Homo sapiens	61-66
25712221-7	2015	One path, where O2 binds to ferrous hIDO1 first, is faster than the second route, which starts with the binding of L-Trp.	Oxygen	16-18	indoleamine 2,3-dioxygenase 1	Homo sapiens	36-41
25626352-0	2015	Five-fold twinned Pd2NiAg nanocrystals with increased surface Ni site availability to improve oxygen reduction activity.	Oxygen	94-100	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	18-21
25889814-13	2015	In the extreme hypoxic conditions (0.2% oxygen), the overexpression of CCAAT enhancer-binding proteins (C/EBPs), especially C/EBPdelta, and HIF-1A upregulated the promoter activities of adipocyte-specific genes such as leptin, CFD, HIG2, LPL, PGAR.	Oxygen	40-46	lipoprotein lipase	Homo sapiens	238-241
25889814-13	2015	In the extreme hypoxic conditions (0.2% oxygen), the overexpression of CCAAT enhancer-binding proteins (C/EBPs), especially C/EBPdelta, and HIF-1A upregulated the promoter activities of adipocyte-specific genes such as leptin, CFD, HIG2, LPL, PGAR.	Oxygen	40-46	angiopoietin like 4	Homo sapiens	243-247
2996882-0	1985	Identification of proteins involved in the regulation of yeast iso- 1-cytochrome C expression by oxygen.	Oxygen	97-103	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	63-69
25688692-6	2015	Nitrate reduction activity, the first step in the denitrification process, was recorded for isolates under simulated anoxic, deep-sea conditions showing ecological significance of fungi in the oxygen-depleted habitats.	Oxygen	193-199	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
25560321-5	2015	We find that epicardial Igf2 expression is controlled in a biphasic manner, first induced by erythropoietin and then regulated by oxygen and glucose with onset of placental function.	Oxygen	130-136	insulin-like growth factor 2	Mus musculus	24-28
2996882-6	1985	These data strongly argue that the CYC1 UAS binding protein(s) that we have identified mediate the oxygen and heme control of cytochrome C biosynthesis.	Oxygen	99-105	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	35-39
2995315-5	1985	Succinate-reduced cytochrome c was oxidized by oxygen via a cyanide-sensitive, membrane-associated system.	Oxygen	47-53	cytochrome c, somatic	Equus caballus	18-30
25635614-1	2015	We have developed a new type of artificial oxygen carrier composed of bovine hemoglobin (bHb) and bovine serum albumin (BSA) prepared by Shirasu porous glass (SPG) membrane emulsification technique.	Oxygen	43-49	albumin	Bos taurus	105-118
25319047-0	2015	BH3-only protein Bim is upregulated and mediates the apoptosis of cardiomyocytes under glucose and oxygen-deprivation conditions.	Oxygen	99-105	Bcl2-like 11	Rattus norvegicus	17-20
2995315-7	1985	Partially purified carbon monoxide-binding cytochrome c, isolated from the cytoplasm, could serve as electron acceptor for NADPH-cytochrome c oxidoreductase; the reduced cytochrome was oxidized by oxygen by a cyanide-insensitive system present in the cytoplasmic fraction.	Oxygen	197-203	cytochrome c, somatic	Equus caballus	43-55
25243909-7	2015	Higher expression of Glut1 detected on iTreg cells generated under hypoxic culture conditions provides a likely explanation for the enhanced proliferation of these cells as compared to those cultured under ambient oxygen.	Oxygen	214-220	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	21-26
25491498-7	2015	During cycling, c-pH was higher (P&lt;=0.034) after HV compared with HP at submaximal workloads in YAD and at 75% of VO2max (maximal oxygen consumption) in ELD.	Oxygen	133-139	carboxypeptidase E	Homo sapiens	16-20
25545945-0	2015	MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4.	Oxygen	64-70	toll like receptor 4	Homo sapiens	111-131
24850805-6	2015	Adult mice exposed to 100% oxygen for 4 days or 60% oxygen for 8 days exhibited alveolar simplification and altered elastin deposition compared to siblings birthed into room air, as well as increased inflammation and fibrotic lung disease following viral infection.	Oxygen	27-33	elastin	Mus musculus	116-123
24850805-6	2015	Adult mice exposed to 100% oxygen for 4 days or 60% oxygen for 8 days exhibited alveolar simplification and altered elastin deposition compared to siblings birthed into room air, as well as increased inflammation and fibrotic lung disease following viral infection.	Oxygen	52-58	elastin	Mus musculus	116-123
25495870-5	2015	Inhibition of TrxR activity by CDNB, combined with exposure to UVA light, produced a substantial loss of LECs and cell damage, with the effects being considerably more severe at 20% O2 compared to 3%.	Oxygen	182-184	peroxiredoxin 5	Homo sapiens	14-18
25226206-2	2015	SP differentiation for 6 days of mESCs toward endoderm at hypoxia of 1% O2, but not at 3% or 21% (normoxia), increased the expression of Sox17 and Foxa2 by 31- and 63-fold above maintenance culture, respectively.	Oxygen	72-74	SRY (sex determining region Y)-box 17	Mus musculus	137-142
2995315-13	1985	It is proposed that energy provision via the high-potential cytochrome c oxidase system in the cytoplasmic membrane is limited by oxygen-sensitive primary dehydrogenases and that the carbon monoxide-binding cytochrome c may have a role as an oxygen scavenger.	Oxygen	130-136	cytochrome c, somatic	Equus caballus	60-72
2995315-13	1985	It is proposed that energy provision via the high-potential cytochrome c oxidase system in the cytoplasmic membrane is limited by oxygen-sensitive primary dehydrogenases and that the carbon monoxide-binding cytochrome c may have a role as an oxygen scavenger.	Oxygen	130-136	cytochrome c, somatic	Equus caballus	207-219
4034284-7	1985	The activity of antioxidant enzymes (glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione reductase) was increased in lungs of newborn rats exposed to 100% oxygen either at birth or 2 days of age.	Oxygen	174-180	glutathione-disulfide reductase	Rattus norvegicus	96-117
25786542-2	2015	To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it secretes an erythroid growth factor, erythropoietin (Epo), which stimulates erythropoiesis in the bone marrow.	Oxygen	12-18	erythropoietin	Mus musculus	121-135
25786542-2	2015	To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it secretes an erythroid growth factor, erythropoietin (Epo), which stimulates erythropoiesis in the bone marrow.	Oxygen	12-18	erythropoietin	Mus musculus	137-140
25539718-0	2015	The expression of epidermal growth factor-like domain 7 regulated by oxygen tension via hypoxia inducible factor (HIF)-1alpha activity.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-125
25539718-13	2015	Egfl7 could be a HIF-1alpha responsive gene regulated by oxygen tension.	Oxygen	57-63	hypoxia inducible factor 1, alpha subunit	Mus musculus	17-27
2861789-2	1985	In the presence of NADPH and molecular oxygen, highly purified preparations of cytochrome P-450 reductase and cytochrome P-450 (isozyme 2) from rabbit liver microsomes catalyze enzyme inactivation.	Oxygen	39-45	cytochrome P450 2B4	Oryctolagus cuniculus	110-137
25689462-1	2015	Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).	Oxygen	74-80	sirtuin 1	Mus musculus	232-241
25689462-1	2015	Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).	Oxygen	74-80	sirtuin 1	Mus musculus	243-248
26027382-8	2015	Thus, insufficient oxygen supply to the nervous tissue at different stages of ontogenesis has a significant effect on the activity and ratio of various forms of cholinesterases exhibiting either growth factor or signaling properties.	Oxygen	19-25	myotrophin	Rattus norvegicus	195-208
25682875-3	2015	Here we show that Cux1-/- MEFs are unable to proliferate in atmospheric (20%) oxygen although they can proliferate normally in physiological (3%) oxygen levels.	Oxygen	146-152	cut-like homeobox 1	Mus musculus	18-22
4015108-1	1985	The affinity of human hemoglobin (Hb4) for dioxygen was determined in 0.050 M bistris, 0.005 M inositol hexaphosphate (IHP) at pH 7.0 and 20.0 degrees C. Binding of dioxygen by Hb4 was determined by detailed spectroscopic analysis of the absorption spectrum in the region from 460 to 620 nm.	Oxygen	43-51	keratin 84	Homo sapiens	34-37
25682875-7	2015	Repair of oxidative DNA damage and proliferation in 20% oxygen were both rescued in Cux1-/- MEFs by ectopic expression of CUX1 or of a recombinant Cut repeat protein that stimulates OGG1 but is devoid of transcription activation potential.	Oxygen	56-62	cut-like homeobox 1	Mus musculus	84-88
25682875-7	2015	Repair of oxidative DNA damage and proliferation in 20% oxygen were both rescued in Cux1-/- MEFs by ectopic expression of CUX1 or of a recombinant Cut repeat protein that stimulates OGG1 but is devoid of transcription activation potential.	Oxygen	56-62	cut-like homeobox 1	Mus musculus	122-126
25428696-0	2015	Aberrant elastin remodeling in the lungs of O2-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin.	Oxygen	44-46	elastin	Mus musculus	9-16
25428696-0	2015	Aberrant elastin remodeling in the lungs of O2-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin.	Oxygen	44-46	elastin	Mus musculus	136-143
25428696-4	2015	Lung histology revealed aberrant elastin production and impaired lung septation in O2-exposed lungs, while tropoelastin, integrin alphav, fibulin-1, fibulin-2 and fibulin-4 gene expression were elevated.	Oxygen	83-85	elastin	Mus musculus	33-40
25428696-5	2015	Dual staining image analysis of lung sections revealed that co-localization of integrin alphav and elastin increased following O2 exposure with elastin distributed throughout the walls of air spaces rather than at septal tips.	Oxygen	127-129	elastin	Mus musculus	99-106
25428696-5	2015	Dual staining image analysis of lung sections revealed that co-localization of integrin alphav and elastin increased following O2 exposure with elastin distributed throughout the walls of air spaces rather than at septal tips.	Oxygen	127-129	elastin	Mus musculus	144-151
25745524-7	2015	An artificially hyperintense signal on FLAIR images can result from magnetic susceptibility artifacts, CSF/vascular pulsation, motion, but can also be found in patients undergoing MRI examinations while receiving supplemental oxygen.	Oxygen	226-232	colony stimulating factor 2	Homo sapiens	103-106
4015108-1	1985	The affinity of human hemoglobin (Hb4) for dioxygen was determined in 0.050 M bistris, 0.005 M inositol hexaphosphate (IHP) at pH 7.0 and 20.0 degrees C. Binding of dioxygen by Hb4 was determined by detailed spectroscopic analysis of the absorption spectrum in the region from 460 to 620 nm.	Oxygen	165-173	keratin 84	Homo sapiens	34-37
2992681-3	1985	The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.	Oxygen	140-146	carbonic anhydrase 1	Rattus norvegicus	38-41
25730079-2	2015	Hypoxia-inducible factor-2alpha (HIF-2alpha) plays an essential role in oxygen homeostasis.	Oxygen	72-78	endothelial PAS domain protein 1	Homo sapiens	0-31
25730079-2	2015	Hypoxia-inducible factor-2alpha (HIF-2alpha) plays an essential role in oxygen homeostasis.	Oxygen	72-78	endothelial PAS domain protein 1	Homo sapiens	33-43
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 1	Mus musculus	35-39
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 3	Mus musculus	45-49
25022804-10	2015	Early oxygen therapies prevented occludin degradation, MMP-9 activation, and reduced HIF-1alpha expression.	Oxygen	6-12	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-95
25615717-7	2015	Moreover, low oxygen tension significantly up-regulated VEGF and bFGF mRNA expression and protein secretion while reducing the expression level of tumour suppressor genes p16, p21, p53, and pRb.	Oxygen	14-20	H3 histone pseudogene 16	Homo sapiens	176-179
25599529-1	2015	NAC genes have been characterized in numerous plants, where they are involved in responses to biotic and abiotic stress, including low oxygen stress.	Oxygen	135-141	synuclein alpha	Homo sapiens	0-3
25599529-3	2015	In model plants, NAC genes have been identified as being responsive to low oxygen.	Oxygen	75-81	synuclein alpha	Homo sapiens	17-20
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	147-153	egl-9 family hypoxia-inducible factor 1	Mus musculus	35-39
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	147-153	egl-9 family hypoxia-inducible factor 3	Mus musculus	45-49
3863194-2	1985	Studies were carried out in rat renal mesangial cell cultures which produce erythropoietin in an oxygen-dependent manner.	Oxygen	97-103	erythropoietin	Rattus norvegicus	76-90
26303471-5	2015	We will consider the role of the AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), an upstream kinase through which AMPK is intimately coupled to changes in oxygen supply via mitochondrial metabolism.	Oxygen	171-177	serine/threonine kinase 11	Homo sapiens	73-88
26303471-5	2015	We will consider the role of the AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), an upstream kinase through which AMPK is intimately coupled to changes in oxygen supply via mitochondrial metabolism.	Oxygen	171-177	serine/threonine kinase 11	Homo sapiens	90-94
3923881-9	1985	Thus, glucose oxidase via generation of active oxygen species stimulated the lung 5-lipoxygenase pathway, and inhibitors of 5-lipoxygenase protected against the oxidant lung injury.	Oxygen	47-53	arachidonate 5-lipoxygenase	Rattus norvegicus	82-96
25082441-7	2015	In this study, we propose a strategy for further engineering S. cerevisiae by altering the oxygen sensing pathway by deleting the transcription factor HAP1, which resulted in an increase of the final recombinant active hemoglobin titer exceeding 7% of the total cellular protein.	Oxygen	91-97	Hap1p	Saccharomyces cerevisiae S288C	151-155
25590809-3	2015	beta-Lap is bioactivated by NADPH:quinone oxidoreductase 1 (NQO1) in a futile redox cycle that consumes oxygen and generates high levels of reactive oxygen species (ROS) that cause extensive DNA damage and rapid PARP1-mediated NAD(+) consumption.	Oxygen	104-110	LAP	Homo sapiens	5-8
25022493-5	2015	One strong cathodic ECL peak located at ~-0.8 V could be observed at the GNP/GR/GCE but not at the GNP/GCE, which should be result from the adsorbed oxygen at the graphene film.	Oxygen	149-155	aminomethyltransferase	Homo sapiens	80-83
3985965-0	1985	Synthesis and characterization of the oxygen and desthio analogues of glutathione as dead-end inhibitors of glutathione S-transferase.	Oxygen	38-44	hematopoietic prostaglandin D synthase	Rattus norvegicus	108-133
25427906-6	2015	This Review will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1 as a result of CYP2E1-derived reactive oxygen intermediates promoting dissociation of the inhibitory thioredoxin from ASK-1.	Oxygen	265-271	mitogen-activated protein kinase kinase kinase 5	Mus musculus	220-225
25427906-6	2015	This Review will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1 as a result of CYP2E1-derived reactive oxygen intermediates promoting dissociation of the inhibitory thioredoxin from ASK-1.	Oxygen	265-271	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	241-247
25427906-6	2015	This Review will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1 as a result of CYP2E1-derived reactive oxygen intermediates promoting dissociation of the inhibitory thioredoxin from ASK-1.	Oxygen	265-271	mitogen-activated protein kinase kinase kinase 5	Mus musculus	344-349
26279426-3	2015	METHODS: We assessed aberrant elastin localization-associated signaling in mouse pups exposed to 85% O2 treated with either IL-1Ra or 1D11, using morphometric analyses, quantitative RT-PCR, immunostaining, and ELISA.	Oxygen	101-103	elastin	Mus musculus	30-37
26279426-6	2015	RESULTS: Elevated levels of IL-1beta, alphavbeta6 and TGF-beta1 were each associated with aberrant elastin production in O2-exposed lungs.	Oxygen	121-123	elastin	Mus musculus	99-106
3993403-5	1985	The calculated ATP production (FATP) was linearly related to P for P greater than 10% of the control value in 96% O2, with the same slope for hypoxia and both inhibitors.	Oxygen	114-116	solute carrier family 27 member 1	Rattus norvegicus	31-35
25924998-3	2015	In organotypic hippocampal slices exposed to N-methyl-N"-nitro-N"-nitrosoguanidine (MNNG), an alkylating agent able to activate PARP, a selective and delayed degeneration of the CA1 pyramidal cells which was anatomically similar to that observed after a short period of oxygen and glucose deprivation (OGD) has been described.	Oxygen	270-276	carbonic anhydrase 1	Rattus norvegicus	178-181
33401814-0	2015	Predictive Microbiology Coupled with Gas (O2 /CO2 ) Transfer in Food/Packaging Systems: How to Develop an Efficient Decision Support Tool for Food Packaging Dimensioning.	Oxygen	42-44	gastrin	Homo sapiens	37-40
25997392-2	2015	Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated alpha subunits (HIF1A/HIF-1alpha or EPAS1/HIF-2alpha), and a constitutively expressed ARNT/HIF-1beta subunit, that serve as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	endothelial PAS domain protein 1	Homo sapiens	197-202
25997392-2	2015	Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated alpha subunits (HIF1A/HIF-1alpha or EPAS1/HIF-2alpha), and a constitutively expressed ARNT/HIF-1beta subunit, that serve as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	endothelial PAS domain protein 1	Homo sapiens	203-213
25997392-2	2015	Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated alpha subunits (HIF1A/HIF-1alpha or EPAS1/HIF-2alpha), and a constitutively expressed ARNT/HIF-1beta subunit, that serve as master regulators of the adaptive response to hypoxia.	Oxygen	47-49	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	247-251
24832965-9	2015	These simulations also highlight the indirect role that mechanics may play in regulating MSC fate by inhibiting blood vessel progression and hence disrupting oxygen availability within regenerating tissues.	Oxygen	158-164	musculin	Homo sapiens	89-92
26236724-5	2015	After low oxygen tension cultivation for 21 days, the mean size of the hypoxia-expanded neurospheres was significantly increased at 5% O2; this correlated with high-level expression of hypoxia-inducible factor-1 alpha (Hif-1alpha), proliferating cell nuclear antigen (PCNA), cyclin D1, Abcg2, nestin, and Nanog proteins but downregulated expression of p27 compared to that in a normoxic condition.	Oxygen	10-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	185-217
26668162-4	2015	In addition, cerebral oxygen saturation (ScO2) was measured using near-infrared spectroscopy, also known as cerebral oximetry.	Oxygen	22-28	synthesis of cytochrome C oxidase 2	Homo sapiens	41-45
26668162-8	2015	When blood COHb levels had returned to normal following oxygen therapy, ScO2 values were 75.9 +- 6.1 (65.5-90.5) in the right frontal region and 74.9 +- 7.8 (62.0-90.0) in the left.	Oxygen	56-62	synthesis of cytochrome C oxidase 2	Homo sapiens	72-76
26668162-9	2015	The differences in ScO2 values before and after oxygen therapy were statistically significant (P &lt;= 0.005).	Oxygen	48-54	synthesis of cytochrome C oxidase 2	Homo sapiens	19-23
3986000-10	1985	Metabolism of 2,4-DNT by liver and lung microsomes yielded mainly 2,4-DNBAlc with lower amounts of 4A2NT and 2A4NT, and their formation was dependent on the presence of oxygen and NADPH.	Oxygen	169-175	5',3'-nucleotidase, cytosolic	Mus musculus	18-21
24388334-6	2015	Stabilisation of HIF1alpha protein in cumulus cells exposed to low oxygen was confirmed by western blot and HIF-mediated transcriptional activity was demonstrated using a transgenic mouse expressing green fluorescent protein under the control of a promoter containing hypoxia response elements.	Oxygen	67-73	hypoxia inducible factor 1, alpha subunit	Mus musculus	17-26
24388334-7	2015	These results indicate that oxygen concentration influences cumulus cell gene expression and support a role for HIF1alpha in mediating the cumulus cell response to varying oxygen.	Oxygen	172-178	hypoxia inducible factor 1, alpha subunit	Mus musculus	112-121
26632221-5	2015	Quartz-crystal microbalance-dissipation measurements suggested that ionic interaction between the oxygen of the terminal hydroxyl groups of titanium and the nitrogen of fibronectin was important for fibronectin immobilization.	Oxygen	98-104	fibronectin 1	Rattus norvegicus	169-180
26632221-5	2015	Quartz-crystal microbalance-dissipation measurements suggested that ionic interaction between the oxygen of the terminal hydroxyl groups of titanium and the nitrogen of fibronectin was important for fibronectin immobilization.	Oxygen	98-104	fibronectin 1	Rattus norvegicus	199-210
6470005-3	1984	The results are consistent with the proposal of nitrogen and oxygen atoms as ligands to the metal in the active site of glyoxalase I.	Oxygen	61-67	glyoxalase I	Homo sapiens	120-132
25363011-8	2015	There is a need for future studies to explore the link between underlying inflammatory mechanisms and hepcidin in oxygen radical diseases.	Oxygen	114-120	hepcidin antimicrobial peptide	Homo sapiens	102-110
25587028-2	2014	Concurrent attenuation of oxidative phosphorylation and HIF-1alpha/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and oxygen-dependent cell death that we term ferroxitosis.	Oxygen	129-135	pyruvate kinase M1/2	Homo sapiens	67-71
6433885-1	1984	The mechanism by which Ant2p [2-(3-chloro-4-trifluoromethyl)anilino-3, 5-dinitrothiophene] inhibits the oxygen evolution capacity of chloroplasts is thought to be due to a rapid reduction of the S2 and S3 oxidation states of the oxygen-evolving complex mediated by the oxidation of endogenous donors such as cytochrome b559.	Oxygen	104-110	solute carrier family 25 member 6	Homo sapiens	23-28
25407336-1	2014	The electrocatalytic proton reduction activity of a Ni bis(diphosphine) (NiP) and a cobaloxime (CoP) catalyst has been studied in water in the presence of the gaseous inhibitors O2 and CO.	Oxygen	178-180	caspase recruitment domain family member 16	Homo sapiens	96-99
25407336-2	2014	CoP shows an appreciable tolerance towards O2, but its activity suffers severely in the presence of CO.	Oxygen	43-45	caspase recruitment domain family member 16	Homo sapiens	0-3
25531909-8	2014	Additionally, tumor necrosis factor-alpha and interleukin-10 mRNA expression levels were significantly higher in rats exposed to hyperbaric oxygen than in controls 24 h after injury.	Oxygen	140-146	interleukin 10	Rattus norvegicus	46-60
25539208-9	2015	Oxygen radical damage to the mucus layer caused by H2O2 was significantly reduced by E2 compared with HT29-MTX + H2O2 without estrogen.	Oxygen	0-6	metaxin 1	Homo sapiens	107-110
25308493-4	2015	We show how to measure GDP-sensitive UCP1-dependent oxygen consumption in non-phosphorylating thymus mitochondria and we show that increased reactive oxygen species production occurs on addition of GDP to non-phosphorylating thymus mitochondria.	Oxygen	52-58	uncoupling protein 1	Homo sapiens	37-41
6433885-1	1984	The mechanism by which Ant2p [2-(3-chloro-4-trifluoromethyl)anilino-3, 5-dinitrothiophene] inhibits the oxygen evolution capacity of chloroplasts is thought to be due to a rapid reduction of the S2 and S3 oxidation states of the oxygen-evolving complex mediated by the oxidation of endogenous donors such as cytochrome b559.	Oxygen	229-235	solute carrier family 25 member 6	Homo sapiens	23-28
6376509-8	1984	Thus in the group, S. cerevisiae, E. coli, B. subtilis, the content of a [4Fe-4S] cluster in amidophosphoribosyltransferase correlates with a mechanism for oxygen-dependent inactivation of the enzyme.	Oxygen	156-162	amidophosphoribosyltransferase	Saccharomyces cerevisiae S288C	93-123
26093967-3	2015	The protons of the protonated amine group are hydrogen bonded to etheric and hydroxyl oxygen atoms of the LAS anion.	Oxygen	86-92	lipoic acid synthetase	Homo sapiens	106-109
25305180-11	2014	Furthermore, similar to the effect of Y-27632, NR1 improved H9c2 cell viability, maintained actin skeleton and mitochondria morphology, and attenuated apoptosis induced by oxygen and glucose deprivation/reoxygenation.	Oxygen	172-178	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	47-50
6088686-2	1984	Admission of oxygen to the bleached ceruloplasmin restored the blue color to about 75% of the original value.	Oxygen	13-19	ceruloplasmin	Homo sapiens	36-49
25657740-5	2014	Compared with model rats that did not receive the treatment, rats exposed to hyperbaric oxygen had fewer apoptotic cells in spinal cord tissue, lower expression levels of aquaporin 4/9 mRNA and protein, and more NF-200 positive nerve fibers.	Oxygen	88-94	aquaporin 4	Rattus norvegicus	171-184
25657740-7	2014	Our findings indicate that hyperbaric oxygen therapy reduces apoptosis, downregulates aquaporin 4/9 mRNA and protein expression in injured spinal cord tissue, improves the local microenvironment for nerve regeneration, and protects and repairs the spinal cord after injury.	Oxygen	38-44	aquaporin 4	Rattus norvegicus	86-99
25167933-1	2015	Oxygen tension is a known regulator of mesenchymal stem cell (MSC) plasticity, differentiation, proliferation, and recruitment to sites of injury.	Oxygen	0-6	musculin	Homo sapiens	62-65
25167933-2	2015	Materials capable of affecting the MSC oxygen-sensing pathway, independently of the environmental oxygen pressure, are therefore of immense interest to the tissue engineering (TE) and regenerative medicine community.	Oxygen	39-45	musculin	Homo sapiens	35-38
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Oxygen	161-168	complement C2	Homo sapiens	291-295
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Oxygen	161-168	complement C2	Homo sapiens	304-308
25505325-7	2014	Forward genetic screens indicate that GLB-5"s effects on O2 sensing require PDL-1, the C. elegans ortholog of mammalian PrBP/PDE6delta protein.	Oxygen	57-59	Phosphodiesterase delta-like protein	Caenorhabditis elegans	76-81
25505325-9	2014	PDL-1 promotes localization of GCY-33 and GCY-35, atypical soluble guanylate cyclases that act as O2 sensors, to the dendritic endings of URX and BAG neurons, where they colocalize with GLB-5.	Oxygen	98-100	Phosphodiesterase delta-like protein	Caenorhabditis elegans	0-5
25505325-11	2014	Dendritic localization is not essential for GCY-35 to function as an O2 sensor, but disrupting pdl-1 alters the URX neuron"s O2 response properties.	Oxygen	125-127	Phosphodiesterase delta-like protein	Caenorhabditis elegans	95-100
25300578-10	2014	Hepatic levels of hypoxia inducible factor-1alpha, an oxygen-sensitive transcriptional regulator of glycolysis and a known beta-catenin binding partner, were higher in HFD-fed TG and lower in KO mice.	Oxygen	54-60	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-49
25481140-8	2014	Using this method we then calculate the isotropic dipole polarizabilities for F(-), Cl(-), O(2-), and S(2-) embedded in the LiF, LiCl, NaF, NaCl, KF, KCl, ZnO, ZnS, MgO, MgS, CaO, CaS, SrO, SrS, BaO, BaS, and other crystals containing halogen, oxygen, or sulphur anions.	Oxygen	91-96	LIF interleukin 6 family cytokine	Homo sapiens	124-127
25460352-4	2014	SOBP-penetration depth and extension was 35 mm +/-4 mm and 36 mm +/-5 mm for carbon ions and oxygen ions respectively.	Oxygen	93-99	sine oculis binding protein homolog	Homo sapiens	0-4
25232021-0	2014	Oxygen modulates human decidual natural killer cell surface receptor expression and interactions with trophoblasts.	Oxygen	0-6	CD177 molecule	Homo sapiens	47-68
25232021-2	2014	We investigated whether different levels of oxygen tension, mimicking the physiological conditions of the decidua in early pregnancy, altered cell surface receptor expression and activity of dNK cells and their interactions with trophoblast.	Oxygen	44-50	CD177 molecule	Homo sapiens	142-163
25232021-7	2014	Alterations in dNK cell surface receptor expression and secreted factors at different oxygen tensions may represent regulation of function within the decidua during the first trimester of pregnancy.	Oxygen	86-92	deoxyribonucleoside kinase	Drosophila melanogaster	15-18
25232021-2	2014	We investigated whether different levels of oxygen tension, mimicking the physiological conditions of the decidua in early pregnancy, altered cell surface receptor expression and activity of dNK cells and their interactions with trophoblast.	Oxygen	44-50	deoxyribonucleoside kinase	Drosophila melanogaster	191-194
6088686-8	1984	Evidence is also presented that ceruloplasmin catalyzes the oxidation of cysteine with a one-electron reduction of oxygen and the formation of superoxide ion, which is then converted to H2O2 by ceruloplasmin.	Oxygen	115-121	ceruloplasmin	Homo sapiens	32-45
25232021-4	2014	SGHPL-4 cells treated with dNK cell CM incubated in oxygen tensions of 10% were significantly more invasive (P &lt; 0.05) and formed endothelial-like networks to a greater extent (P &lt; 0.05) than SGHPL-4 cells treated with dNK cell CM incubated in oxygen tensions of 3% or 21%.	Oxygen	52-58	deoxyribonucleoside kinase	Drosophila melanogaster	27-30
25232021-4	2014	SGHPL-4 cells treated with dNK cell CM incubated in oxygen tensions of 10% were significantly more invasive (P &lt; 0.05) and formed endothelial-like networks to a greater extent (P &lt; 0.05) than SGHPL-4 cells treated with dNK cell CM incubated in oxygen tensions of 3% or 21%.	Oxygen	250-256	deoxyribonucleoside kinase	Drosophila melanogaster	27-30
6088686-11	1984	We conclude that there is a single electron transfer from cysteine directly to oxygen using one specific copper of ceruloplasmin, type 1b.	Oxygen	79-85	ceruloplasmin	Homo sapiens	115-128
25232021-6	2014	This study demonstrates dNK cell phenotype and secreted factors are modulated by oxygen tension, which induces changes in trophoblast invasion and endovascular-like differentiation.	Oxygen	81-87	deoxyribonucleoside kinase	Drosophila melanogaster	24-27
25120128-2	2014	Here, we explored the conceptually novel motivation to use supplemental oxygen as a treatment to inhibit the hypoxia/HIF-1alpha-CD39/CD73-driven accumulation of extracellular adenosine in the TME in order to weaken the tumor protection.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
25120128-2	2014	Here, we explored the conceptually novel motivation to use supplemental oxygen as a treatment to inhibit the hypoxia/HIF-1alpha-CD39/CD73-driven accumulation of extracellular adenosine in the TME in order to weaken the tumor protection.	Oxygen	72-78	5' nucleotidase, ecto	Mus musculus	133-137
6485147-7	1984	Thus the cytochrome P-450 levels of isolated hepatocytes show qualitatively the same response to varying oxygen tensions that they do in intact animals.	Oxygen	105-111	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	9-25
25120128-3	2014	We report that hyperoxic breathing (60 % O2) decreased the TME hypoxia, as well as levels of HIF-1alpha and downstream target proteins of HIF-1alpha in the TME according to proteomic studies in mice.	Oxygen	41-43	hypoxia inducible factor 1, alpha subunit	Mus musculus	93-103
25120128-3	2014	We report that hyperoxic breathing (60 % O2) decreased the TME hypoxia, as well as levels of HIF-1alpha and downstream target proteins of HIF-1alpha in the TME according to proteomic studies in mice.	Oxygen	41-43	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-148
25344581-7	2014	Hypoxia (1% oxygen) induced ADAM9 expression and functional activity in low ADAM9-expressing gastric cancer cells that was inhibited by siRNA knockdown or RAV-18 antibody to levels in normoxic cells.	Oxygen	12-18	ADAM metallopeptidase domain 9	Homo sapiens	28-33
25348393-5	2014	Thus, sulfide from the springs, locally reduced salinity and O2 from the Dead Sea water are responsible for the abundant microbial biomass around the springs.	Oxygen	61-63	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
25306099-2	2014	This study sought to investigate the effects of acute growth hormone (GH) administration on the expression of myoglobin (Mb) and Glut4 glucose transporter, two important limiting factors for O2 and glucose utilization for energy production, in cardiac muscle cells of treated rats.	Oxygen	191-193	solute carrier family 2 member 4	Rattus norvegicus	129-134
25344581-7	2014	Hypoxia (1% oxygen) induced ADAM9 expression and functional activity in low ADAM9-expressing gastric cancer cells that was inhibited by siRNA knockdown or RAV-18 antibody to levels in normoxic cells.	Oxygen	12-18	ADAM metallopeptidase domain 9	Homo sapiens	76-81
25440060-2	2014	Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1alpha and Hif-2alpha) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-alpha signaling.	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	138-148
25440060-7	2014	These results establish Hif-2alpha as a negative regulator of peroxisome abundance and metabolism and suggest a mechanism by which cells attune peroxisomal function with oxygen availability.	Oxygen	170-176	endothelial PAS domain protein 1	Homo sapiens	24-34
25192830-7	2014	The change in oxygen metabolism by FAI was associated with that in CBF obtained by LSI, although the change in CBF was greater than that in oxygen metabolism.	Oxygen	14-20	CCAAT enhancer binding protein zeta	Homo sapiens	67-70
25192830-7	2014	The change in oxygen metabolism by FAI was associated with that in CBF obtained by LSI, although the change in CBF was greater than that in oxygen metabolism.	Oxygen	140-146	CCAAT enhancer binding protein zeta	Homo sapiens	67-70
25192830-8	2014	COMPARISON WITH EXISTING METHOD(S): We revealed that the relationship between oxygen metabolism and CBF as measured by our system was in good agreement with the relationship between CMRO2 and CBF in human PET studies.	Oxygen	78-84	CCAAT enhancer binding protein zeta	Homo sapiens	100-103
25192830-8	2014	COMPARISON WITH EXISTING METHOD(S): We revealed that the relationship between oxygen metabolism and CBF as measured by our system was in good agreement with the relationship between CMRO2 and CBF in human PET studies.	Oxygen	78-84	CCAAT enhancer binding protein zeta	Homo sapiens	182-195
6319404-3	1984	Dopamine beta-hydroxylase was incubated with p-hydroxybenzyl cyanide, ascorbate, and O2 and the products of the hydroxylation reaction were monitored by high performance liquid chromatography.	Oxygen	85-87	dopamine beta-hydroxylase	Homo sapiens	0-25
24998603-7	2014	The viability of gastrin knockdown cells exposed to hypoxia (1% O2) in vitro was diminished because of loss of resistance against hypoxia-induced apoptosis, and the effect was partly reversed by treatment with non-amidated, but not amidated, gastrin.	Oxygen	64-66	gastrin	Homo sapiens	17-24
25064694-0	2014	Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen.	Oxygen	62-68	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	33-38
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	103-109	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	224-229
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	115-121	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	224-229
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	115-121	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	224-229
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	115-121	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	224-229
25501739-1	2014	PURPOSE: This study aimed to determine whether a controlled portal blood arterialization by a liver extracorporeal device (L.E.O2 NARDO) is effective in treating acute hepatic failure (AHF) induced through CCl4 administration in a swine model.	Oxygen	127-129	C-C motif chemokine 4	Sus scrofa	206-210
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	301-303	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	224-229
6319404-6	1984	Incubation of dopamine beta-hydroxylase with [ring-3H]p-hydroxybenzyl cyanide, ascorbate, and O2 resulted in incorporation of detectable radiolabel into enzyme only when 100% O2 (0.4 X Km) was present.	Oxygen	94-96	dopamine beta-hydroxylase	Homo sapiens	14-39
6319404-6	1984	Incubation of dopamine beta-hydroxylase with [ring-3H]p-hydroxybenzyl cyanide, ascorbate, and O2 resulted in incorporation of detectable radiolabel into enzyme only when 100% O2 (0.4 X Km) was present.	Oxygen	175-177	dopamine beta-hydroxylase	Homo sapiens	14-39
6324739-1	1984	The biological consequences of acetimidylation of all 19 epsilon-amino groups of horse cytochrome c are a slight decrease in both the redox potential of the protein and its ability to stimulate oxygen uptake in the cytochrome c-depleted-mitochondria assay.	Oxygen	194-200	cytochrome c, somatic	Equus caballus	87-99
25090961-4	2014	For multiple As adatoms adsorption in close vicinity, ionicity of the As-C bonds are found to decrease to support As-As cohesion; the net result of which is manifested as better binding of dioxygen molecule with them and additional weakening of the O-O bond in the adsorbed state.	Oxygen	189-197	steroid sulfatase	Homo sapiens	70-74
25184335-0	2014	Oxygen non-stoichiometry phenomena in Pr1-xZrxO2-y compounds (0.02 &lt; x &lt; 0.5).	Oxygen	0-6	transmembrane protein 37	Homo sapiens	38-41
25034305-6	2014	Here, we make an attempt to summarize recent knowledge on the survival of MSCs under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact.	Oxygen	89-95	musculin	Homo sapiens	74-77
25231683-0	2014	All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor alpha signaling pathway.	Oxygen	70-76	retinoic acid receptor, alpha	Rattus norvegicus	109-137
6324739-1	1984	The biological consequences of acetimidylation of all 19 epsilon-amino groups of horse cytochrome c are a slight decrease in both the redox potential of the protein and its ability to stimulate oxygen uptake in the cytochrome c-depleted-mitochondria assay.	Oxygen	194-200	cytochrome c, somatic	Equus caballus	215-227
6696448-5	1984	Similarly, incorporation into the assay media of cytochrome b5 decreases the apparent Kd values of both the amine substrate and the oxygen donor, as determined by optical titration.	Oxygen	132-138	cytochrome b5 type A	Homo sapiens	49-62
25351418-5	2014	We show that DICER expression is suppressed by hypoxia through an epigenetic mechanism that involves inhibition of oxygen-dependent H3K27me3 demethylases KDM6A/B and results in silencing of the DICER promoter.	Oxygen	115-121	dicer 1, ribonuclease III	Homo sapiens	13-18
25351418-5	2014	We show that DICER expression is suppressed by hypoxia through an epigenetic mechanism that involves inhibition of oxygen-dependent H3K27me3 demethylases KDM6A/B and results in silencing of the DICER promoter.	Oxygen	115-121	dicer 1, ribonuclease III	Homo sapiens	194-199
25378960-6	2014	RESULTS: Compared with basal values, maximal oxygen uptake had significantly increased in EG1 (from 53.3+-4.0 mL/min/kg to 54.8+-3.0 mL/min/kg at 6 weeks [P&lt;0.05] and to 57.0+-3.2 mL/min/kg at 12 weeks [P&lt;0.001]).	Oxygen	45-51	mediator complex subunit 28	Homo sapiens	90-93
25378960-8	2014	After 12 weeks of training, maximal oxygen uptake was significantly higher in EG1 than in EG2 (P&lt;0.05).	Oxygen	36-42	mediator complex subunit 28	Homo sapiens	78-81
25143993-8	2014	Based on the data obtained it is proposed that the detachment of the -NMe2 group from the coordination sphere in the semiquinone intermediate is followed for dioxygen binding and activation to yield the extradiol cleavage product.	Oxygen	158-166	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	70-74
25066474-6	2014	Striking decreases in both the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) were observed in GPAT-1 (-/-) CD4(+) T cells following CD3/CD28 stimulation indicating an inherent cellular defect in energy production.	Oxygen	31-37	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	126-132
25106706-10	2014	Overexpression of Trx1 in H1299 cells utilizing an inducible construct increased cell survival during hyperoxia, whereas siRNA knockdown of Trx1 during oxygen treatment reduced cell viability.	Oxygen	152-158	thioredoxin	Homo sapiens	140-144
6704150-3	1984	Low levels of [14C]DDT binding to microsomal lipids occurred under atmospheric oxygen but, in contrast to protein binding, DDT-phospholipid binding was increased up to 20-fold by oxygen depletion.	Oxygen	79-85	D-dopachrome tautomerase	Rattus norvegicus	19-22
6704150-3	1984	Low levels of [14C]DDT binding to microsomal lipids occurred under atmospheric oxygen but, in contrast to protein binding, DDT-phospholipid binding was increased up to 20-fold by oxygen depletion.	Oxygen	179-185	D-dopachrome tautomerase	Rattus norvegicus	123-126
25057876-10	2014	The maximal oxygen uptake was 21 +- 3 (SE) (P) and 36 +- 3(C) mL/kg min (2P &lt; .05).	Oxygen	12-18	plexin B1	Homo sapiens	39-64
25163913-4	2014	The effect of dietary MFGM plus exercise was accompanied by higher oxygen consumption and lower respiratory quotient, as determined by indirect calorimetry.	Oxygen	67-73	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	22-26
6312629-3	1983	Pulmonary angiotensin converting enzyme (ACE) activity, a biochemical marker of endothelial cell injury, was decreased after a 72-hr oxygen exposure and progressively increased above control levels during the recovery period (130%, 168 hr) and paralleled lung protein content.	Oxygen	133-139	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	10-39
25358785-0	2014	Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.	Oxygen	118-120	H3 histone pseudogene 16	Homo sapiens	19-22
6312629-3	1983	Pulmonary angiotensin converting enzyme (ACE) activity, a biochemical marker of endothelial cell injury, was decreased after a 72-hr oxygen exposure and progressively increased above control levels during the recovery period (130%, 168 hr) and paralleled lung protein content.	Oxygen	133-139	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	41-44
25358785-5	2014	Under 21% O2, increased p38 phosphorylation led to activation of p21.	Oxygen	10-12	H3 histone pseudogene 16	Homo sapiens	65-68
24878268-1	2014	OBJECTIVES: The purpose of this study was to examine trends in oxygen administration following the 2010 American Heart Association guidelines recommendation to withhold oxygen therapy for patients with uncomplicated presentations of ACS whose SpO2 is 94% or higher.	Oxygen	63-69	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	233-236
24878268-1	2014	OBJECTIVES: The purpose of this study was to examine trends in oxygen administration following the 2010 American Heart Association guidelines recommendation to withhold oxygen therapy for patients with uncomplicated presentations of ACS whose SpO2 is 94% or higher.	Oxygen	169-175	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	233-236
25358785-8	2014	Activation of p38/p21/NRF-2 in hDPSCs cultured under ambient oxygen tension inhibits stem cell proliferation and upregulates NRF-2 antioxidant defenses.	Oxygen	61-67	H3 histone pseudogene 16	Homo sapiens	18-21
6356291-13	1983	Streptolysin O is an oxygen-labile (thiol-activated) cytolysin.	Oxygen	21-27	perforin 1	Homo sapiens	53-62
24712343-9	2014	HIF-1alpha gene silencing in ATDC5 cells attenuated the lubricin expression response to the oxygen tension.	Oxygen	92-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-10
6636349-0	1983	Re: Acute oxygen toxicity in a saturation diver working in the North Sea.	Oxygen	10-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	69-72
25137438-3	2014	Furthermore, BEt3/O2 is a preferred initiator in industrial processes, as it is economical, is low in toxicity, and lends way to easier workup.	Oxygen	18-20	trafficking protein particle complex subunit 3	Homo sapiens	13-17
25400763-0	2014	Role of hypoxia-inducible factor-1alpha and survivin in oxygen-induced retinopathy in mice.	Oxygen	56-62	hypoxia inducible factor 1, alpha subunit	Mus musculus	8-39
25296188-0	2014	Engineering pyranose 2-oxidase for modified oxygen reactivity.	Oxygen	44-50	proline dehydrogenase 1	Homo sapiens	12-30
25108226-8	2014	Furthermore, activation and expression of PPARalpha both attenuated the oxidant-induced suppression of mitochondrial O2 consumption in human retinal capillary pericytes.	Oxygen	117-119	peroxisome proliferator activated receptor alpha	Homo sapiens	42-51
6848491-6	1983	An absolute requirement of the proposed mechanism is that the loss of the fatty acid must proceed via an unusual cleavage of the dihydroxyacetone-P C-1 to oxygen bond instead of the usual cleavage at the fatty acid acyl to oxygen bond.	Oxygen	155-161	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	148-151
25400763-5	2014	Fluorescence angiography, immunostaining and HE staining were used to assess the visualization of retinal vascularization and the expression of HIF-1alpha and survivin protein in retina oxygen-induced retinopathy was characterized by clusters of neovascularization and regions of non-perfusion.	Oxygen	186-192	hypoxia inducible factor 1, alpha subunit	Mus musculus	144-154
24749509-3	2014	Results showed increased cell survival and maintenance of the undifferentiated state with elevated levels of nuclear TERT in 2% O2-cultured hESCs despite no significant difference in telomerase activity compared with their high-O2-cultured counterparts.	Oxygen	128-130	telomerase reverse transcriptase	Homo sapiens	117-121
25014067-2	2014	Hypoxia-inducible factor-1alpha is the primary transcription factor that is responsible for regulating the cellular response to changes in oxygen tension.	Oxygen	139-145	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
6848491-6	1983	An absolute requirement of the proposed mechanism is that the loss of the fatty acid must proceed via an unusual cleavage of the dihydroxyacetone-P C-1 to oxygen bond instead of the usual cleavage at the fatty acid acyl to oxygen bond.	Oxygen	223-229	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	148-151
24749509-5	2014	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed variations in transcript levels of full-length and alternate splice variants of TERT in hESCs cultured under varying O2 atmospheres.	Oxygen	192-194	telomerase reverse transcriptase	Homo sapiens	155-159
24665097-3	2014	Thus, in response to low oxygen (hypoxia) or increased CO2/H(+) (acid hypercapnia), chemoreceptor type I cells depolarize and release excitatory neurotransmitters, such as ATP, which stimulate postsynaptic P2X2/3 receptors on afferent nerve terminals.	Oxygen	25-31	purinergic receptor P2X 2	Homo sapiens	206-212
25250598-0	2014	High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning.	Oxygen	92-98	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	50-71
25089804-8	2014	Our finding suggested that HIF-1alpha expression was involved in microglial activation in vitro and was regulated by oxygen supply.	Oxygen	117-123	hypoxia inducible factor 1, alpha subunit	Mus musculus	27-37
6848491-7	1983	In the present investigation, we have synthesized hexadecanoyl dihydroxyacetone-P containing oxygen-18 exclusively at the dihydroxyacetone-P C-1 oxygen.	Oxygen	93-99	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	141-144
24734982-5	2014	Maintenance of mouse PSCs in low oxygen was associated with a significant increase in the expression of early differentiation markers FGF5 and Eomes, while conversely we observed decreased expression of these genes in human PSCs.	Oxygen	33-39	eomesodermin	Mus musculus	143-148
6848491-7	1983	In the present investigation, we have synthesized hexadecanoyl dihydroxyacetone-P containing oxygen-18 exclusively at the dihydroxyacetone-P C-1 oxygen.	Oxygen	145-151	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	141-144
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	eomesodermin	Mus musculus	168-173
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	SRY (sex determining region Y)-box 17	Mus musculus	202-207
25124830-2	2014	The Mnx Co3 x O4 delta materials showed ultrahigh oxygen evolution activity and strong durability in alkaline solutions, and are capable of delivering a current density of 10 mA cm(-2) at 1.58 V versus the reversible hydrogen electrode in 0.1 M KOH solution, which is superior in comparison to IrO2 catalysts under identical experimental conditions, and comparable to the most active noble-metal and transition-metal oxygen evolution electrocatalysts reported so far.	Oxygen	50-56	keratin 86	Homo sapiens	4-7
25124830-2	2014	The Mnx Co3 x O4 delta materials showed ultrahigh oxygen evolution activity and strong durability in alkaline solutions, and are capable of delivering a current density of 10 mA cm(-2) at 1.58 V versus the reversible hydrogen electrode in 0.1 M KOH solution, which is superior in comparison to IrO2 catalysts under identical experimental conditions, and comparable to the most active noble-metal and transition-metal oxygen evolution electrocatalysts reported so far.	Oxygen	417-423	keratin 86	Homo sapiens	4-7
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	eomesodermin	Mus musculus	253-258
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	SRY (sex determining region Y)-box 17	Mus musculus	260-265
6848491-8	1983	Using this substrate, we have shown that cleavage of hexadecanoyl dihydroxyacetone-P at the C-1 to oxygen bond is linked to O-alkyl dihydroxyacetone-P synthesis.	Oxygen	99-105	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	92-95
6304829-9	1983	Myoglobin deoxygenation was linearly related to cytochrome c reduction under all conditions of hypoxia, indicating steep oxygen gradients.	Oxygen	12-18	LOW QUALITY PROTEIN: myoglobin	Oryctolagus cuniculus	0-9
25401015-12	2014	Our study shows that sOCT can be potentially used for estimating oxygen saturation of blood with the accuracy below 1% and the spatial resolution of OCT image better than 20 mum.	Oxygen	65-71	plexin A2	Homo sapiens	22-25
25028064-1	2014	van der Waals complexes of sulfur dioxide (SO2) with oxygen (O2) and nitrogen (N2) have been investigated by using MP2 and aug-cc-pVXZ (X = D, T) basis set.	Oxygen	44-46	tryptase pseudogene 1	Homo sapiens	115-118
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	46-53	complement component 4B (Chido blood group)	Mus musculus	130-133
24866933-0	2014	Usefulness of myoglobin containing cobalt heme cofactor in designing a myoglobin-based artificial oxygen carrier.	Oxygen	98-104	myoglobin	Homo sapiens	14-23
24866933-0	2014	Usefulness of myoglobin containing cobalt heme cofactor in designing a myoglobin-based artificial oxygen carrier.	Oxygen	98-104	myoglobin	Homo sapiens	71-80
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Oxygen	114-121	complement component 4B (Chido blood group)	Mus musculus	130-133
24866933-1	2014	The structure and reactivity of cobalt-replaced myoglobin (Mb) were investigated to explore its possible application as an artificial oxygen carrier.	Oxygen	134-140	myoglobin	Homo sapiens	48-57
24866933-7	2014	The present results on cobalt-substituted Mb are useful in designing myoglobin-based oxygen carriers.	Oxygen	85-91	myoglobin	Homo sapiens	69-78
24777984-6	2014	GCH1(fl/fl)Tie2cre mice demonstrated virtually absent endothelial NO bioactivity and significantly greater O2 ( -) production.	Oxygen	107-109	GTP cyclohydrolase 1	Mus musculus	0-4
7161256-3	1982	To clarify the functional role of the 2- and 4-side chains of heme in myoglobin oxygenation, we synthesized several new hemins carrying nonnatural side chains at positions 2 and 4, reconstituted myoglobins with them, and investigated their optical, ionization, and oxygen-binding properties.	Oxygen	80-86	myoglobin	Homo sapiens	70-79
24992925-0	2014	Methylprednisolone inhibits the proliferation and affects the differentiation of rat spinal cord-derived neural progenitor cells cultured in low oxygen conditions by inhibiting HIF-1alpha and Hes1 in vitro.	Oxygen	145-151	hes family bHLH transcription factor 1	Rattus norvegicus	192-196
24121014-3	2014	This study aimed to examine the relationship between changes in cerebral blood volume (CBV) and cerebral Hb oxygen saturation (ScO2) after a HI insult and the low amplitude-integrated electroencephalography (aEEG) duration concomitantly observed.	Oxygen	108-114	synthesis of cytochrome C oxidase 2	Homo sapiens	127-131
16346140-1	1982	Bacteria able to perform dissimilatory nitrate reduction to ammonium were isolated from low-oxygen masses in the Baltic Sea.	Oxygen	92-98	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	120-123
24794156-7	2014	Mechanistically, n-3 PUFAs induced upregulation of angiopoietin 2 (Ang 2) in astrocytes after tFCI and stimulated extracellular Ang 2 release from cultured astrocytes after oxygen and glucose deprivation.	Oxygen	173-179	angiopoietin 2	Mus musculus	128-133
25126540-8	2014	Regarding the molecular pathways implicated in the oncogenic transformation, one of the first accepted theories was based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive."	Oxygen	214-220	hypoxia inducible factor 1, alpha subunit	Mus musculus	160-191
25126540-8	2014	Regarding the molecular pathways implicated in the oncogenic transformation, one of the first accepted theories was based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive."	Oxygen	214-220	hypoxia inducible factor 1, alpha subunit	Mus musculus	193-202
25073509-0	2014	Oxygen differentially affects the hox proteins Hoxb5 and Hoxa5 altering airway branching and lung vascular formation.	Oxygen	0-6	homeobox A5	Homo sapiens	57-62
24996283-9	2014	Additionally, when we examined PPAR-alpha and PPARGC1A genotype distributions according to the aerobic performance test parameters, we found a statistically significant association between velocity, time and maximal oxygen consumption and PPAR-alpha and PPARGC1A genotypes (p &lt; 0.001).	Oxygen	216-222	peroxisome proliferator-activated receptor alpha	Meleagris gallopavo	31-41
24996283-9	2014	Additionally, when we examined PPAR-alpha and PPARGC1A genotype distributions according to the aerobic performance test parameters, we found a statistically significant association between velocity, time and maximal oxygen consumption and PPAR-alpha and PPARGC1A genotypes (p &lt; 0.001).	Oxygen	216-222	peroxisome proliferator-activated receptor alpha	Meleagris gallopavo	239-249
24849570-6	2014	RESULTS: In the absence of insulin, reduction of BACE1 activity increased glucose uptake and oxidation, GLUT4myc cell surface translocation, and basal rate of oxygen consumption.	Oxygen	159-165	beta-site APP cleaving enzyme 1	Mus musculus	49-54
24849570-7	2014	In contrast, overexpressing BACE1 in C2C12 myotubes decreased glucose uptake, glucose oxidation and oxygen consumption rate.	Oxygen	100-106	beta-site APP cleaving enzyme 1	Mus musculus	28-33
24898625-4	2014	Some composites are efficient Mn-based catalysts with TOF (mmol O2 per mol Mn per second) ~ 2.6.	Oxygen	64-66	FEZ family zinc finger 2	Homo sapiens	54-57
6291625-2	1982	Reduced glutathione, dithiothreitol and superoxide dismutase has a protective effect in homogenates and in partially purified ornithine decarboxylase exposed to the xanthine/xanthine oxidase reaction, while diethyldithiocarbamate, which is an inhibitor of superoxide dismutase, potentiated the damage induced by O2- on enzyme activity.	Oxygen	312-314	ornithine decarboxylase 1	Rattus norvegicus	126-149
25028129-4	2014	Furthermore, we find that the amount of fluorescent DOM at a given apparent oxygen utilization is greater in the deep water of the Japan Sea than it is in the North Pacific, where the highest level of fluorescent DOM in the open ocean was previously observed.	Oxygen	76-82	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	137-140
24585023-3	2014	Adding a large excess of O2 to the reacting flow allows determination of products resulting from oxidation of the initial primary (Rp) and secondary (Rs) radicals formed via the Cl  + DEK reaction.	Oxygen	25-27	DEK proto-oncogene	Homo sapiens	184-187
24859377-3	2014	The function of Mb as an O2 storage depot is well appreciated, especially during systolic compression.	Oxygen	25-27	myoglobin	Homo sapiens	16-18
24859377-5	2014	We recently discovered the role of Mb as a myocardial O2 sensor; in its oxygenated state Mb scavenges NO, protecting the heart from the deleterious effects of excessive NO.	Oxygen	54-56	myoglobin	Homo sapiens	35-37
24859377-5	2014	We recently discovered the role of Mb as a myocardial O2 sensor; in its oxygenated state Mb scavenges NO, protecting the heart from the deleterious effects of excessive NO.	Oxygen	54-56	myoglobin	Homo sapiens	89-91
24585023-4	2014	Because of resonance stabilization, the secondary DEK radical (3-oxopentan-2-yl) reaction with O2 has a shallow alkyl peroxy radical (RsO2) well and no energetically low-lying product channels.	Oxygen	95-97	DEK proto-oncogene	Homo sapiens	50-53
6291625-5	1982	The exposure of rats to 100% oxygen for 3 h reduced significantly the isoproterenol-induced heart ornithine decarboxylase activity.	Oxygen	29-35	ornithine decarboxylase 1	Rattus norvegicus	98-121
6982711-0	1982	Vanadyl (IV) ion dependent enhancement of oxygen binding to hemoglobin and myoglobin.	Oxygen	42-48	myoglobin	Homo sapiens	75-84
24589481-10	2014	CONCLUSION: Disruption of NRG1-ErbB4 signaling in the parvalbumin-positive interneurons might, at least partially, contribute to the isoflurane-induced hippocampus-dependent cognitive impairment after exposure to isoflurane carried by 100% O2 in aged mice.	Oxygen	240-242	erb-b2 receptor tyrosine kinase 4	Mus musculus	31-36
24722450-7	2014	Hypoxia-induced gene transcription is controlled by the transcription factors hypoxia-inducible transcription factor (HIF)-1alpha and HIF2alpha, which are constitutively produced but stable only under low oxygen conditions.	Oxygen	205-211	endothelial PAS domain protein 1	Homo sapiens	134-143
24930884-1	2014	We demonstrate the applicability of the linear diffusion model recently proposed for the current-voltage, Igb-Ugb, characteristics of blocking grain boundaries in solid electrolytes to various oxygen-ion and proton conductors: the model precisely reproduces the Igb-Ugb characteristics of La-, Sm-, Gd-, and Y-doped ceria as well as Y-doped barium zirconate to provide accurate explanations to the "power law" behavior of the Igb-Ugb relationship, i.e. Igb   Ugb(n), experimentally observed.	Oxygen	193-199	CD79b molecule	Homo sapiens	106-109
6807983-0	1982	Inhibition of oxygen exchange by chemical modifiers at the sulfhydryl 1 or reactive lysine residue of myosin.	Oxygen	14-20	myosin heavy chain 14	Homo sapiens	102-108
25057944-5	2014	We measured the blood oxygen level dependent (BOLD) response function of MT and MST using a motion density signal, comparing with area V1.	Oxygen	22-28	misato mitochondrial distribution and morphology regulator 1	Homo sapiens	80-83
24815824-3	2014	We examined whether CD109 is able to regulate extracellular matrix deposition under low oxygen tension in vivo using transgenic mice overexpressing CD109 in the epidermis.	Oxygen	88-94	CD109 antigen	Mus musculus	20-25
24815824-9	2014	Manipulating CD109 levels may have potential therapeutic value for the treatment of fibrotic skin disorders associated with poor oxygen delivery.	Oxygen	129-135	CD109 antigen	Mus musculus	13-18
6807983-2	1982	During the hydrolysis of MgATP by myosin, there is an extensive exchange of oxygen between water and the terminal phosphate group of bound nucleotide, which results from a repeated cycle of hydrolytic cleavage and its reversal.	Oxygen	76-82	myosin heavy chain 14	Homo sapiens	34-40
25000594-2	2014	Oxygen gas bubbles were clearly produced on the FTO electrode at a low overpotential under neutral pH conditions containing Co-DMB.	Oxygen	0-6	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	48-51
6807983-5	1982	Although these modifications of the protein are chemically different, and the sulfhydryl 1 group and the reactive lysine residue are far apart in the primary chain of the myosin head, the two modifications caused a similar marked inhibition of oxygen exchange.	Oxygen	244-250	myosin heavy chain 14	Homo sapiens	171-177
24754893-8	2014	The results showed that simultaneous activation of beta2AR with a beta2AR agonist and inhibition of beta1AR with a selective beta1AR blocker normalized myocardial oxygen consumption, decreased myocardial damage, augmented cardiomyocyte survival, improved cardiac function, reduced the incidence of arrhythmia, thus decreasing the occurrence of cardiac events in perioperative aged rats undergoing non-cardiac surgery.	Oxygen	163-169	adrenoceptor beta 2	Rattus norvegicus	51-58
24748594-5	2014	SIRT3(kd) cells were more vulnerable to simulated IR injury and exhibited a 46% decrease in mitochondrial complex I (Cx I) activity with low O2 consumption rates compared with controls.	Oxygen	141-143	sirtuin 3	Rattus norvegicus	0-5
24645910-2	2014	The TPD spectra for both H2O and CO2 have well-resolved peaks corresponding to desorption from bridge-bonded oxygen (Ob), Ti5c, and defect sites in order of increasing peak temperature.	Oxygen	109-115	complement C2	Homo sapiens	25-36
24585023-6	2014	On the other hand, reaction of the primary DEK radical (3-oxopentan-1-yl) with O2 has several accessible bimolecular product channels.	Oxygen	79-81	DEK proto-oncogene	Homo sapiens	43-46
6282362-6	1982	However, pretreatment with PAF (10(-7) M) enhanced approximately threefold the O2 utilization found when cells were subsequently stimulated with 10(-7) M FMLP.	Oxygen	79-81	PCNA clamp associated factor	Homo sapiens	27-30
24705306-4	2014	Together, our findings suggest that Hif-1alpha and Hif-2alpha competitively bind to NICD and dynamically regulate the activation of Notch signaling in GSCs likely depending on different oxygen tensions, providing improved therapeutic opportunities for malignant gliomas.	Oxygen	186-192	endothelial PAS domain protein 1	Homo sapiens	51-61
24920629-5	2014	Ischemia induced either by embolic middle cerebral artery occlusion (MCAO) in vivo or by oxygen and glucose deprivation in brain slices caused calpain-dependent conversion of the Cdk5-activating cofactor p35 to p25.	Oxygen	89-95	cyclin dependent kinase 5	Homo sapiens	179-183
6123064-10	1982	A kinetic assay for phenylalanine hydroxylase based on measurement of oxygen consumption in described.	Oxygen	70-76	phenylalanine hydroxylase	Rattus norvegicus	20-45
24809677-7	2014	Radical chain autoxidation of BPh4(-) by O2 also occurred in the presence of Sc(OTf)3 without [(TMC)Fe(IV)(O)](2+), initiating the autocatalytic oxidation of [(TMC)Fe(II)](2+) with O2 and BPh4(-) to yield [(TMC)Fe(IV)(O)](2+).	Oxygen	41-43	POU class 5 homeobox 1	Homo sapiens	77-85
24809677-7	2014	Radical chain autoxidation of BPh4(-) by O2 also occurred in the presence of Sc(OTf)3 without [(TMC)Fe(IV)(O)](2+), initiating the autocatalytic oxidation of [(TMC)Fe(II)](2+) with O2 and BPh4(-) to yield [(TMC)Fe(IV)(O)](2+).	Oxygen	181-183	POU class 5 homeobox 1	Homo sapiens	77-85
24129754-7	2014	Oxygen concentration distributions within cell-seeded MACF hydrogels were found to have higher concentrations of oxygen at the edge of the hydrogels and less severe drops in O2 gradient as compared with MAC hydrogel controls.	Oxygen	0-6	microtubule actin crosslinking factor 1	Homo sapiens	54-58
24129754-7	2014	Oxygen concentration distributions within cell-seeded MACF hydrogels were found to have higher concentrations of oxygen at the edge of the hydrogels and less severe drops in O2 gradient as compared with MAC hydrogel controls.	Oxygen	113-119	microtubule actin crosslinking factor 1	Homo sapiens	54-58
24129754-7	2014	Oxygen concentration distributions within cell-seeded MACF hydrogels were found to have higher concentrations of oxygen at the edge of the hydrogels and less severe drops in O2 gradient as compared with MAC hydrogel controls.	Oxygen	174-176	microtubule actin crosslinking factor 1	Homo sapiens	54-58
24753539-8	2014	Because a photoreceptor-mediated PHR1 activation was not detectable under hypoxia, our data suggest that a chloroplast-derived retrograde signal, potentially arising from metabolic changes, regulates PHR1 activity under both oxygen and phosphate deficiency.	Oxygen	225-231	phosphate starvation response 1	Arabidopsis thaliana	33-37
7187435-5	1982	TTS2 min at 4 kc/s was significantly less with oxygen inhalation, confirming a previous study; however, no relationship was found between amount of oxygen consumed and the amount of TTS during pure oxygen inhalation.	Oxygen	47-53	patatin like phospholipase domain containing 2	Homo sapiens	0-4
24753539-8	2014	Because a photoreceptor-mediated PHR1 activation was not detectable under hypoxia, our data suggest that a chloroplast-derived retrograde signal, potentially arising from metabolic changes, regulates PHR1 activity under both oxygen and phosphate deficiency.	Oxygen	225-231	phosphate starvation response 1	Arabidopsis thaliana	200-204
24726658-7	2014	RESULTS: Lowering O2 concentration from 21% to the physiologically relevant 5% level substantially affected cell characteristics, with induction of stemness-related-transcription-factor and stimulation of cell proliferative capacity, with increased colony-forming unit fibroblasts (CFU-F) centers exerting OCT4A, NANOG and HIF-1alpha and HIF-2alpha immunoreactivity.	Oxygen	18-20	endothelial PAS domain protein 1	Homo sapiens	338-348
24886938-4	2014	Molecular modeling studies revealed that the binding mode would be affected via forming an additional hydrogen bond by incorporating an oxygen atom on the C-2 side chain.	Oxygen	136-142	complement C2	Homo sapiens	155-158
7061465-7	1982	When the artificial ligand coordinated through an oxygen atom, the spectrum of pentacoordinate P-450LM4 changed to one closely resembling that of native, hexacoordinate P-450LM2.	Oxygen	50-56	cytochrome P450 1A2	Oryctolagus cuniculus	95-103
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Oxygen	225-231	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	4-50
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Oxygen	225-231	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	52-56
24849811-1	2014	The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1beta, plays a pivotal role in the adaptive responses to (micro-)environmental stresses such as dioxin exposure and oxygen deprivation (hypoxia).	Oxygen	225-231	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	78-114
24828299-3	2014	As results, our in vitro study revealed that the r1 and r2 (relaxivities) of the oxygen-treated serum were 0.22 mM(-1)   s(-1) and 0.19 mM(-1)   s(-1) , respectively.	Oxygen	81-87	CD1b molecule	Homo sapiens	49-58
26483911-0	2014	Sleep apnea and oxygen saturation in adults at 2640 m above sea level.	Oxygen	16-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
24849811-5	2014	However, there is emerging evidence that tumor cells derived from different entities are able to upregulate ARNT, especially under low oxygen tension in a cell-specific manner.	Oxygen	135-141	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	108-112
7061465-7	1982	When the artificial ligand coordinated through an oxygen atom, the spectrum of pentacoordinate P-450LM4 changed to one closely resembling that of native, hexacoordinate P-450LM2.	Oxygen	50-56	cytochrome P450 2B4	Oryctolagus cuniculus	169-177
7061465-8	1982	The spectrum of P-450LM2 was unchanged in the presence of oxygen-coordinating ligands.	Oxygen	58-64	cytochrome P450 2B4	Oryctolagus cuniculus	16-24
24711448-0	2014	Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.	Oxygen	78-84	prostaglandin E synthase 3	Homo sapiens	34-37
24821292-6	2014	The highest occupied molecular orbital (HOMO) of CS shows leading carbonyl pi character with contributions from other heavy (non-H) atoms in the molecule, while the HOMO of 2-oxazolidinone (OX2) has leading nitrogen, carbon, and oxygen ppi characters.	Oxygen	229-235	CD200 molecule	Homo sapiens	190-193
24761800-1	2014	The new role of graphene (GR) in boosting the two-electron reduction of O2 to H2O2 has been first identified in the GR-WO3 nanorod (NR) nanocomposite photocatalysts, which are fabricated by a facile, solid electrostatic self-assembly strategy to integrate the positively charged branched poly(ethylenimine) (BPEI)-GR (BGR) and negatively charged WO3 NRs at room temperature.	Oxygen	72-74	C-type lectin domain containing 7A	Homo sapiens	318-321
24627887-4	2014	Using 4-MBA as a Raman dye, the SERS performance of the substrates was evaluated after being cleaned by low oxygen and argon plasma.	Oxygen	108-114	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	32-36
7061465-12	1982	These results provide strong evidence that the native sixth ligand in P-450LM2 is oxygen rather than nitrogen.	Oxygen	82-88	cytochrome P450 2B4	Oryctolagus cuniculus	70-78
6800787-4	1982	The important role of catalase as a scavenger for H2O2 in the aerobic cells (Drosophila cells in culture are consuming oxygen) led to the demonstration of catalatic properties of this induced enzyme.	Oxygen	119-125	Catalase	Drosophila melanogaster	22-30
24802082-0	2014	Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice.	Oxygen	57-63	fatty acid binding protein 4, adipocyte	Mus musculus	0-28
24802082-5	2014	We hypothesized that FABP4 deficiency could ameliorate pathological retinal vascularization and investigated this hypothesis using a well-characterized mouse model of oxygen-induced retinopathy (OIR).	Oxygen	167-173	fatty acid binding protein 4, adipocyte	Mus musculus	21-26
24804981-1	2014	Fully electroactive multilayer architectures combining the redox protein cytochrome c and the enzyme laccase by the use of silica nanoparticles as artificial matrix have been constructed on gold electrodes capable of direct dioxygen reduction.	Oxygen	224-232	cytochrome c, somatic	Equus caballus	73-85
24804981-4	2014	The electrochemical properties and performance of the nanobiomolecular entities were investigated by cyclic voltammetry, indicating, that a multistep electron transfer cascade, from the electrode via cytochrome c in the layered system toward the enzyme laccase, and here to molecular dioxygen was achieved.	Oxygen	284-292	cytochrome c, somatic	Equus caballus	200-212
24627558-7	2014	Cellular bioenergetics measurements confirm that attenuation of UCP-1 expression by PRR activation is accompanied by suppression of both basal and isoproterenol-stimulated oxygen consumption rates and isoproterenol-induced uncoupled respiration from proton leak; however, maximal respiration and ATP-coupled respiration are not changed.	Oxygen	172-178	uncoupling protein 1	Homo sapiens	64-69
7334203-5	1981	The hairless condition of the hr/hr genotype seems to contribute to increased oxygen consumption beyond that expected as a consequence of their lower average body weight.	Oxygen	78-84	lysine demethylase and nuclear receptor corepressor	Mus musculus	4-12
24648344-0	2014	Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1alpha in breast cancer.	Oxygen	35-41	rhomboid 5 homolog 1	Homo sapiens	6-23
24648344-7	2014	We show that RHBDF1 interaction with the receptor of activated protein-C kinase-1 (RACK1) in breast cancer cells prevents RACK1-assisted, oxygen-independent HIF1alpha degradation.	Oxygen	138-144	rhomboid 5 homolog 1	Homo sapiens	13-19
24533641-0	2014	Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via regulation of HIF-1alpha.	Oxygen	67-73	hypoxia inducible factor 1, alpha subunit	Mus musculus	112-122
24533641-3	2014	We investigated the hypothesis that degradation of HIF-1alpha as a master regulator of angiogenesis in hypoxic condition, using beta-lapachone, would confer protection against hypoxia-induced retinopathy without affecting physiological vascular development in mice with oxygen-induced retinopathy (OIR), an animal model of ROP.	Oxygen	270-276	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
7334203-5	1981	The hairless condition of the hr/hr genotype seems to contribute to increased oxygen consumption beyond that expected as a consequence of their lower average body weight.	Oxygen	78-84	lysine demethylase and nuclear receptor corepressor	Mus musculus	30-32
7334203-5	1981	The hairless condition of the hr/hr genotype seems to contribute to increased oxygen consumption beyond that expected as a consequence of their lower average body weight.	Oxygen	78-84	lysine demethylase and nuclear receptor corepressor	Mus musculus	33-35
7334203-8	1981	On an absolute basis, the hr/hr genotype seems to have approximately 54 percent as much affect on oxygen consumption as the ob/ob genotype.	Oxygen	98-104	lysine demethylase and nuclear receptor corepressor	Mus musculus	26-28
25079642-9	2014	Electrochemical methods revealed that HA could enhance the electrocatalytic current of both in vitro and in vivo Cyt c towards oxygen and thiosulfate, suggesting enhanced EET.	Oxygen	127-133	cytochrome c, somatic	Equus caballus	113-118
24510616-6	2014	By immunochemical localization of astrocytes (GFAP), activated microglia (Cd11b), and total microglia (Iba-1), we identified an oxygen-sensing glial layer in the NTS, in which astrocytes are first activated after 1-6 hr of hypoxia, followed by microglia after 6-24 hr of hypoxia.	Oxygen	128-134	glial fibrillary acidic protein	Mus musculus	46-50
7334203-8	1981	On an absolute basis, the hr/hr genotype seems to have approximately 54 percent as much affect on oxygen consumption as the ob/ob genotype.	Oxygen	98-104	lysine demethylase and nuclear receptor corepressor	Mus musculus	29-31
24510616-6	2014	By immunochemical localization of astrocytes (GFAP), activated microglia (Cd11b), and total microglia (Iba-1), we identified an oxygen-sensing glial layer in the NTS, in which astrocytes are first activated after 1-6 hr of hypoxia, followed by microglia after 6-24 hr of hypoxia.	Oxygen	128-134	induction of brown adipocytes 1	Mus musculus	103-108
6448633-1	1980	During the hydrolysis of MgATP catalyzed by myosin, ATP bound to the protein undergoes a reaction such that the beta-nonbridge oxygen atoms exchange position with the beta gamma-bridge oxygen atom.	Oxygen	127-133	myosin heavy chain 14	Homo sapiens	44-50
24664814-2	2014	The method operates under mild reaction conditions (RT) with molecular oxygen (1 atm) as the sole reoxidant of Pd.	Oxygen	71-77	ATM serine/threonine kinase	Homo sapiens	81-84
6448633-1	1980	During the hydrolysis of MgATP catalyzed by myosin, ATP bound to the protein undergoes a reaction such that the beta-nonbridge oxygen atoms exchange position with the beta gamma-bridge oxygen atom.	Oxygen	185-191	myosin heavy chain 14	Homo sapiens	44-50
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	24-28
6268262-3	1980	When ferricytochrome c and cysteine are mixed in an oxygen electrode a "burst" of oxygen uptake is seen, the decline in which parallels the reduction of cytochrome c.	Oxygen	52-58	cytochrome c, somatic	Equus caballus	10-22
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	POU class 5 homeobox 1	Homo sapiens	36-40
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	endothelial PAS domain protein 1	Homo sapiens	115-124
24460692-7	2014	However, physical removal of dissolved oxygen prior to RF-PRT protects ADAMTS13 as well as FVIII and fibrinogen from damage, indicating a direct role for reactive oxygen species.	Oxygen	39-45	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	71-79
24632683-10	2014	Thus, when both H2O and CO2 were present in the adsorption system, H2O would compete with CO2 for the oxygen vacancy sites and further decrease the amount of CO2 adsorption and decomposition.	Oxygen	102-108	complement C2	Homo sapiens	16-27
24661879-0	2014	USF-1 inhibition protects against oxygen-and-glucose-deprivation-induced apoptosis via the downregulation of miR-132 in HepG2 cells.	Oxygen	34-40	upstream transcription factor 1	Homo sapiens	0-5
24661879-2	2014	The aim of the current study was to explore the regulatory mechanism of USF-1 in HepG2 cells exposed to oxygen and glucose deprivation (OGD).	Oxygen	104-110	upstream transcription factor 1	Homo sapiens	72-77
24695462-2	2014	Inhibition of the oxygen-dependent negative regulator of HIF-1alpha, prolyl hydroxylase domain-2 (PHD-2), leads to increased HIF-1alpha and mimics various cellular and physiological responses to hypoxia.	Oxygen	18-24	hypoxia inducible factor 1, alpha subunit	Mus musculus	57-67
24695462-2	2014	Inhibition of the oxygen-dependent negative regulator of HIF-1alpha, prolyl hydroxylase domain-2 (PHD-2), leads to increased HIF-1alpha and mimics various cellular and physiological responses to hypoxia.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 1	Mus musculus	69-96
24695462-2	2014	Inhibition of the oxygen-dependent negative regulator of HIF-1alpha, prolyl hydroxylase domain-2 (PHD-2), leads to increased HIF-1alpha and mimics various cellular and physiological responses to hypoxia.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 1	Mus musculus	98-103
24695462-2	2014	Inhibition of the oxygen-dependent negative regulator of HIF-1alpha, prolyl hydroxylase domain-2 (PHD-2), leads to increased HIF-1alpha and mimics various cellular and physiological responses to hypoxia.	Oxygen	18-24	hypoxia inducible factor 1, alpha subunit	Mus musculus	125-135
6268262-3	1980	When ferricytochrome c and cysteine are mixed in an oxygen electrode a "burst" of oxygen uptake is seen, the decline in which parallels the reduction of cytochrome c.	Oxygen	82-88	cytochrome c, somatic	Equus caballus	10-22
24746669-5	2014	Mitochondria-targeted cyclin B1/Cdk1 increases mitochondrial respiration with enhanced oxygen consumption and ATP generation, which provides cells with efficient bioenergy for G2/M transition and shortens overall cell-cycle time.	Oxygen	87-93	cyclin B1	Homo sapiens	22-31
24746669-5	2014	Mitochondria-targeted cyclin B1/Cdk1 increases mitochondrial respiration with enhanced oxygen consumption and ATP generation, which provides cells with efficient bioenergy for G2/M transition and shortens overall cell-cycle time.	Oxygen	87-93	cyclin dependent kinase 1	Homo sapiens	32-36
6165149-3	1980	By cesarean section fetal aortic blood was collected and the oxygen halfsaturation pressure (P 50) was determined as described by Lichtman et al.	Oxygen	61-67	Y-box-binding protein 1	Oryctolagus cuniculus	93-97
24782600-4	2014	Detailed analysis of the above changes indicates that the following events occur in aging gastric mucosa: reduced mucosal blood flow and impaired oxygen delivery cause hypoxia, which leads to activation of the early growth response-1 (egr-1) transcription factor.	Oxygen	146-152	early growth response 1	Homo sapiens	235-240
24422556-0	2014	Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.	Oxygen	35-41	thymidylate synthetase	Homo sapiens	72-92
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	Oxygen	202-204	dynamin 1 like	Homo sapiens	9-13
7416157-4	1980	The findings suggest the presence of two sequential mechanisms of adaptation to progressively lower atmosphere oxygen pressure: One operating from sea level to 1860 meters, which leads to a progressively increasing number of relatively microcytic RBC; and a second one -- from 1860 to 2670 meters -- in which there is an increased but constant number of progressively more normocytic RBC, so that a simplistic model of equal magnitude increases in the three parameters and is seen at 2670 meters, but not at the intermediate altitudes.	Oxygen	111-117	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	147-150
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	Oxygen	202-204	E74 like ETS transcription factor 4	Homo sapiens	17-20
24375083-8	2014	Iba1(+) cells were significantly increased in the striatum and hippocampal CA1 after both 21 and 100% O2.	Oxygen	102-104	induction of brown adipocytes 1	Mus musculus	0-4
24743169-8	2014	In oxygen-exposed rats, aorta elastin/collagen content ratio was significantly decreased, the expression of elastinolytic cathepsin S was increased whereas collagenolytic cathepsin K was decreased.	Oxygen	3-9	cathepsin K	Rattus norvegicus	171-182
24743169-9	2014	By immunofluorescence we observed an increase in MMP-2 and TIMP-1 staining in aortas of oxygen-exposed rats whereas TIMP-2 staining was reduced, indicating a shift in the balance towards degradation of the extra-cellular matrix and increased deposition of collagen.	Oxygen	88-94	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	116-122
24375083-8	2014	Iba1(+) cells were significantly increased in the striatum and hippocampal CA1 after both 21 and 100% O2.	Oxygen	102-104	carbonic anhydrase 1	Mus musculus	75-78
43890-9	1979	Saline equilibrated with 2% CO2; 98% O2 produced a steady reduction in pH1 of about 0.25 unit in 2--3 min.	Oxygen	29-31	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	71-74
24550398-4	2014	Gene disruption studies show that AgtA, the enzyme responsible for addition of the final two galactose residues, in alpha-linkages to the Skp1 core trisaccharide, is unexpectedly critical for oxygen-dependent terminal development.	Oxygen	192-198	S-phase kinase associated protein 1	Homo sapiens	138-142
24966926-1	2014	Globin family was famous for oxygen supply function of its members such as hemoglobin and myoglobin.	Oxygen	29-35	myoglobin	Homo sapiens	90-99
24717514-12	2014	NNMT inhibition in adipocytes increases oxygen consumption in an ODC-, SSAT- and PAO-dependent manner.	Oxygen	40-46	polyamine oxidase (exo-N4-amino)	Mus musculus	81-84
159329-5	1979	Thus, although 90% of the RBCs were removed, elevated erythropoietin activity was not detected immediately because the perfluorocarbon compound replaced the capacity of the RBCs as an oxygen and carbon dioxide carrier.	Oxygen	184-190	erythropoietin	Rattus norvegicus	54-68
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Oxygen	41-47	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	24-27
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Oxygen	41-47	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	155-158
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Oxygen	202-208	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	24-27
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Oxygen	202-208	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	155-158
24691535-5	2014	The adsorption of HCN is much stronger in rGO with oxygen-containing group on the surface than that at the edge.	Oxygen	51-57	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	18-21
24781731-0	2014	Myosin heavy chain composition in the vastus lateralis muscle in relation to oxygen uptake and heart rate during cycling in humans.	Oxygen	77-83	myosin heavy chain 14	Homo sapiens	0-6
24781731-1	2014	In this study we examined the relationship between fast myosin heavy chain (MyHC2) content in the vastus lateralis and the rate of oxygen uptake (VO2) and heart rate (HR) increase during an incremental exercise in 38, young, healthy men.	Oxygen	131-137	myosin heavy chain 14	Homo sapiens	56-62
24486887-13	2014	In conclusion, AP4M1 is not only down-regulated at both the mRNA and protein levels, but also redistributed from dendrites to axons in oxygen-glucose deprived hippocampal neurons.	Oxygen	135-141	adaptor related protein complex 4 subunit mu 1	Homo sapiens	15-20
24556985-5	2014	GLTSCR2 enhances mitochondrial function and is required for the maintenance of oxygen consumption, consistent with a pivotal role in the control of cellular respiration.	Oxygen	79-85	NOP53 ribosome biogenesis factor	Homo sapiens	0-7
24458145-8	2014	After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated.	Oxygen	11-13	hexokinase 2	Mus musculus	110-113
582666-3	1979	It is believed that the hemorrhages and visual loss were secondary to the sudden increase in CSF pressure caused by the excess volume of oxygen injected.	Oxygen	137-143	colony stimulating factor 2	Homo sapiens	93-96
24414254-5	2014	Vit D treatment improved oxygen saturations (78 vs. 87%; P &lt; 0.001) and postnatal survival (84% vs. 57%; P &lt; 0.001) after exposure to IA ETX compared with IA ETX alone.	Oxygen	25-31	vitrin	Rattus norvegicus	0-3
24686644-1	2014	A method for measuring diffuse reflectivity using cubic cavity based on the variable port fraction method was developed by measuring oxygen P11 line at 762 nm using tunable diode laser absorption spectroscopy.	Oxygen	133-139	endonuclease, poly(U) specific	Homo sapiens	140-143
24486702-16	2014	The ability of MB to activate SIRT1 promotes mitochondrial biogenesis and oxygen consumption and activates AMPK, contributing to anti-lipogenesis in the liver.	Oxygen	74-80	sirtuin 1	Mus musculus	30-35
24507647-10	2014	Retinal oxygen can induce over-expression of HIF-1alpha and VEGF.	Oxygen	8-14	vascular endothelial growth factor A	Rattus norvegicus	60-64
476940-2	1979	Our results correlated well with those by the routine SMAC glucose oxidase/peroxidase 3-methyl-2-benzothiazolinone hydrazone-N,N-dimethylaniline method (y = 1.02x - 49.4; r = 0.99) and the glucose oxidase oxygen-rate method (y = 0.99x + 14; r = 0.99) with the Beckman Glucose Analyzer.	Oxygen	205-211	diablo IAP-binding mitochondrial protein	Homo sapiens	54-58
24333653-3	2014	Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1(UNCL)) or of PARP-1(24) conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-1(89) was cytotoxic.	Oxygen	125-131	unc-50 inner nuclear membrane RNA binding protein	Homo sapiens	68-80
24533623-4	2014	(1)H NMR and ESI-TOF mass spectra under various conditions suggested that the photoexcited Pt1* reacts with dissolved dioxygen to form a reactive intermediate, and the ensuing dark reactions afforded two different products without any decomposition.	Oxygen	118-126	zinc finger protein 77	Homo sapiens	91-94
24533623-6	2014	The photosensitized reaction in the presence of an (1)O2-generating photosensitizer, methylene blue (MB), also produced Pt1O and Pt2, indicating that the reaction between (1)O2 and ground-state Pt1 is the important step.	Oxygen	51-56	zinc finger protein 77	Homo sapiens	120-123
24533623-6	2014	The photosensitized reaction in the presence of an (1)O2-generating photosensitizer, methylene blue (MB), also produced Pt1O and Pt2, indicating that the reaction between (1)O2 and ground-state Pt1 is the important step.	Oxygen	171-176	zinc finger protein 77	Homo sapiens	120-123
457876-2	1979	Cytochrome P-450 (C-P450) is found in the lung and may modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical mediator.	Oxygen	120-126	Cytochrome P450 1A1	Canis lupus familiaris	0-24
24093724-6	2014	In vitro, acute exposure of AECs to hypoxia (0.5-3% O2 for 1-6 h) rapidly decreased transepithelial Na(+) transport as assessed by equivalent short-circuit current Ieq and the amiloride-sensitive component of Na(+) current across the apical membrane, reflecting ENaC activity.	Oxygen	52-54	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	262-266
24458713-6	2014	We found that CYP2C (localized in wild-type monocytes/macrophages) is upregulated in oxygen-induced retinopathy, whereas sEH is suppressed, resulting in an increased retinal epoxide:diol ratio.	Oxygen	85-91	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	14-19
24408918-3	2014	Here, we show that genetically distinct human cancer cells exploit eIF4E2-directed protein synthesis to form cellular masses larger than approximately 0.15 mm, the diffusion limit of oxygen.	Oxygen	183-189	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	67-73
24408918-4	2014	Cancer cells depleted of eIF4E2 are indistinguishable from control cells under normoxic conditions, but are unable to survive and proliferate in low oxygen conditions.	Oxygen	149-155	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	25-31
24375723-6	2014	MCT4 expression was shown to be controlled by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) since under low oxygen levels, transfecting astrocyte cultures with a siRNA targeting HIF-1alpha largely prevented MCT4 induction.	Oxygen	132-138	hypoxia inducible factor 1, alpha subunit	Mus musculus	71-102
24375723-6	2014	MCT4 expression was shown to be controlled by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) since under low oxygen levels, transfecting astrocyte cultures with a siRNA targeting HIF-1alpha largely prevented MCT4 induction.	Oxygen	132-138	hypoxia inducible factor 1, alpha subunit	Mus musculus	104-114
226162-8	1979	The reconstituted semisynthetic cytochrome c was purified by ion exchange chromatography and was shown to have the same oxygen uptake as native cytochrome c when assayed in the succinate oxidase system.	Oxygen	120-126	cytochrome c, somatic	Equus caballus	32-44
24518819-2	2014	Previously we showed that EPOR expression in endothelial cells is increased at low oxygen tension and that EPO stimulation of endothelial cells during hypoxia can increase endothelial nitric oxide (NO) synthase (eNOS) expression and activation as well as NO production.	Oxygen	83-89	erythropoietin receptor	Homo sapiens	26-30
24518819-4	2014	Human umbilical vein endothelial cells (HUVEC) treated with 10-50 muM of NO donor diethylenetriamine NONOate (DETANO) for 24h showed significant induction of EPOR gene expression at 5% and 2% of oxygen.	Oxygen	195-201	erythropoietin receptor	Homo sapiens	158-162
24518819-5	2014	Also human bone marrow microvascular endothelial cell line (TrHBMEC) cultured at 21 and 2% oxygen with 50 muM DETANO demonstrated a time and oxygen dependent induction of EPOR mRNA expression after 24 and 48 h, particularly at low oxygen tension.	Oxygen	91-97	erythropoietin receptor	Homo sapiens	171-175
24518819-5	2014	Also human bone marrow microvascular endothelial cell line (TrHBMEC) cultured at 21 and 2% oxygen with 50 muM DETANO demonstrated a time and oxygen dependent induction of EPOR mRNA expression after 24 and 48 h, particularly at low oxygen tension.	Oxygen	141-147	erythropoietin receptor	Homo sapiens	171-175
24518819-5	2014	Also human bone marrow microvascular endothelial cell line (TrHBMEC) cultured at 21 and 2% oxygen with 50 muM DETANO demonstrated a time and oxygen dependent induction of EPOR mRNA expression after 24 and 48 h, particularly at low oxygen tension.	Oxygen	141-147	erythropoietin receptor	Homo sapiens	171-175
24518819-6	2014	EPOR protein was also induced by DETANO at 2% oxygen in TrHBMEC and HUVEC.	Oxygen	46-52	erythropoietin receptor	Homo sapiens	0-4
24518819-8	2014	In reporter gene assays, DETANO treatment of HeLa cells at 2% oxygen increased EPOR promoter activity indicated by a 48% increase in luciferase activity with a 2 kb EPOR promoter fragment and a 71% increase in activity with a minimal EPOR promoter fragment containing 0.2 kb 5".	Oxygen	62-68	erythropoietin receptor	Homo sapiens	79-83
24518819-9	2014	We found that DETANO activated MAPK kinase in TrHBMEC both in normoxia and hypoxia, while MAPK kinase inhibition showed significant reduction of EPOR mRNA gene expression at low oxygen tension, suggesting MAPK involvement in NO mediated induction of EPOR.	Oxygen	178-184	erythropoietin receptor	Homo sapiens	145-149
24518819-12	2014	These observations provide a new effect of NO on EPOR expression to enhance EPO response in endothelial cells, particularly at low oxygen tensions.	Oxygen	131-137	erythropoietin receptor	Homo sapiens	49-53
24366041-8	2014	In conclusion, the current study demonstrates the relationship between O-GlcNAc glycosylation and hypoxia during diabetic retinopathy and that hyperglycemia induced O2 consumption activates HIF1alpha and O-GlcNAc modification protein in the same retinal layer.	Oxygen	165-167	hypoxia inducible factor 1, alpha subunit	Mus musculus	190-199
24420571-3	2014	By using BY-2 tobacco cells, it was shown that both NaCl- and sorbitol-induced PCD seemed to be dependent on superoxide anion (O2 (-)) generation by NADPH-oxidase.	Oxygen	127-129	respiratory burst oxidase homolog protein A-like	Nicotiana tabacum	149-162
24420571-4	2014	In the case of NaCl, an early influx of sodium through non-selective cation channels participates in the development of PCD through mitochondrial dysfunction and NADPH-oxidase-dependent O2 (-) generation.	Oxygen	186-188	respiratory burst oxidase homolog protein A-like	Nicotiana tabacum	162-175
24288134-4	2014	In the presence of oxygen, DA induced alpha-synuclein oligomerization in a dose-dependent manner.	Oxygen	19-25	synuclein alpha	Homo sapiens	38-53
23913502-3	2014	Recently, we demonstrated that the oxygen sensor HIF-prolyl hydroxylase-2 (PHD2) plays a detrimental role in tumor cells, stimulating systemic growth and metastasis in mice.	Oxygen	35-41	egl-9 family hypoxia-inducible factor 1	Mus musculus	49-73
455139-1	1979	The time course of changes in blood and brain catecholamines, catechol O-methyltransferase (COMT), ammonia, and amino acids leading to convulsion by high pressure oxygen breathing (OHP) in rats has been investigated.	Oxygen	163-169	catechol-O-methyltransferase	Rattus norvegicus	92-96
23913502-3	2014	Recently, we demonstrated that the oxygen sensor HIF-prolyl hydroxylase-2 (PHD2) plays a detrimental role in tumor cells, stimulating systemic growth and metastasis in mice.	Oxygen	35-41	egl-9 family hypoxia-inducible factor 1	Mus musculus	75-79
24749345-5	2014	RESULTS Comparing with the RA group, we found that newborn rats exposed to 600 mL/L oxygen develop a heterogeneous parenchymal lung injury with areas of arrested alveolarization and growth mixed with areas of interstitial thinning, meanwhile, both the expression of IL-6 and IL-10 in serum and lung tissue increased significantly (P &lt; 0.05).	Oxygen	84-90	interleukin 10	Rattus norvegicus	275-280
24749345-8	2014	In comparison with RA group, the expression levels of IGF-I in O2 group were significantly lower in 4 d and 7 d but were significantly higher in 14 d (P &lt; 0.05); In comparison with O2 group, the expression levels of IGF-I in O2 group significantly increased in 4 d and 7 d but significantly reduced in 14 d (P &lt; 0.05).	Oxygen	63-65	insulin-like growth factor 1	Rattus norvegicus	54-59
24749345-8	2014	In comparison with RA group, the expression levels of IGF-I in O2 group were significantly lower in 4 d and 7 d but were significantly higher in 14 d (P &lt; 0.05); In comparison with O2 group, the expression levels of IGF-I in O2 group significantly increased in 4 d and 7 d but significantly reduced in 14 d (P &lt; 0.05).	Oxygen	63-65	insulin-like growth factor 1	Rattus norvegicus	219-224
24749345-8	2014	In comparison with RA group, the expression levels of IGF-I in O2 group were significantly lower in 4 d and 7 d but were significantly higher in 14 d (P &lt; 0.05); In comparison with O2 group, the expression levels of IGF-I in O2 group significantly increased in 4 d and 7 d but significantly reduced in 14 d (P &lt; 0.05).	Oxygen	184-186	insulin-like growth factor 1	Rattus norvegicus	54-59
24360989-3	2014	Exposing the BMCs to 3%, 5%, or 10% O2 in the presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) generated tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells, consistent with OCs.	Oxygen	36-38	colony stimulating factor 1	Homo sapiens	109-145
101236-2	1978	This observation is consistent with mechanistic pathways involving an enediol intermediate and eliminates suggested mechanisms that involve covalent intermediates between the enzyme and ribulose 1,5-bisphosphate in which the substrate oxygen at C-2 or C-3 is compulsorily lost.	Oxygen	235-241	complement C2	Homo sapiens	245-255
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	120-122	serglycin	Mus musculus	61-64
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	120-122	serglycin	Mus musculus	211-214
210349-0	1978	An effect of corticosteroids and 100% oxygen on aryl hydrocarbon hydroxylase, cytochrome-c reductase, and free radical formation by rat lung microsomes.	Oxygen	38-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	48-76
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	127-129	serglycin	Mus musculus	61-64
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	127-129	serglycin	Mus musculus	211-214
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	127-129	serglycin	Mus musculus	61-64
24365975-8	2014	CONCLUSION: A complex equilibrium is established between NO, sGC and CcO in vessels in function of the concentration of O2: as O2 falls, NO inhibition of mitochondrial O2 consumption increases and activation of sGC decreases, thus promoting a rapid increase in tone in both pulmonary and systemic vessels, which is followed by the triggering of NO-independent vasodilator/vasoconstrictor mechanisms.	Oxygen	127-129	serglycin	Mus musculus	211-214
24323731-2	2014	Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia-ischemia in laboratory models of stroke.	Oxygen	63-69	erythropoietin	Rattus norvegicus	0-14
24323731-2	2014	Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia-ischemia in laboratory models of stroke.	Oxygen	63-69	erythropoietin	Rattus norvegicus	16-19
24586910-11	2014	CONCLUSIONS: We identified pre-treatment high serum ferritin level and high alveolar-arterial oxygen gradient as poor prognostic factors in DM-A/SIP patients undergoing early CSA/GC combination therapy and showed that the outcomes were poor in patients with both factors.	Oxygen	94-100	major histocompatibility complex, class II, DM alpha	Homo sapiens	140-148
24304835-6	2014	Isolated mitochondria from AMPKgamma3(R200Q) muscle had greater maximal, ADP-stimulated oxygen consumption rate.	Oxygen	88-94	protein kinase AMP-activated non-catalytic subunit gamma 3	Sus scrofa	27-37
23353821-6	2014	We observed that MYC drives the evasion of reactive-oxygen stress-induced melanocyte senescence, caused by activated receptor tyrosine kinase signaling.	Oxygen	52-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-20
24465590-2	2014	Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive".	Oxygen	217-223	hypoxia inducible factor 1, alpha subunit	Mus musculus	163-194
207332-3	1978	The oscillations in the peroxidase (donor: hydrogen-peroxide oxidoreductase, EC 1.11.1.7)-catalyzed reaction between NADH and O2 are undamped when the reaction is carried out in a system open to both substrates and when 2,4-dichlorophenol and methylene blue are present in the solution.	Oxygen	126-128	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	77-81
24465590-2	2014	Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive".	Oxygen	217-223	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-205
24211189-2	2014	In oxygen phototrophs, GAPDH and PRK regulation involves the redox-sensitive protein CP12.	Oxygen	3-9	CP12 domain-containing protein 2	Arabidopsis thaliana	85-89
24211189-9	2014	Overall, the results suggest that the role of CP12 in oxygen phototrophs needs to be extended beyond light/dark regulation, and include protection of enzymes belonging to Calvin-Benson cycle from oxidative stress.	Oxygen	54-60	CP12 domain-containing protein 2	Arabidopsis thaliana	46-50
621277-4	1978	Isobutyl methyl xanthine (IMX), carbamylcholine, histamine, and gastrin each independently stimulated oxygen uptake by the unfractionated mucosal cells.	Oxygen	102-108	gastrin	Homo sapiens	64-71
24333633-7	2014	Moreover we observed oxygen uptake and generation of membrane potential probably linked to D-lactate oxidation which is a product of SLG hydrolysis.	Oxygen	21-27	sialic acid binding Ig like lectin 12	Homo sapiens	133-136
24226635-5	2014	The O2 treatment was &gt;95% O2 for 7 d, followed by 60% O2 for 14 d. RESULTS: Rat pups born to LPS-injected dams exhibited significantly higher lung interferon-gamma and interleukin-1beta (IL-1beta) on postnatal day 7 than the pups born to NS-injected dams.	Oxygen	4-6	interferon gamma	Rattus norvegicus	150-166
24368083-2	2014	Here, the reaction of reduced flavin and dioxygen catalyzed by pyranose 2-oxidase (P2O), a flavoenzyme oxidase that is unique in its formation of C4a-hydroperoxyflavin, was investigated by density functional calculations, transient kinetics, and site-directed mutagenesis.	Oxygen	41-49	complement C4A (Rodgers blood group)	Homo sapiens	146-149
24368083-3	2014	Based on work from the 1970s-1980s, the current understanding of the dioxygen activation process in flavoenzymes is believed to involve electron transfer from flavin to dioxygen and subsequent proton transfer to form C4a-hydroperoxyflavin.	Oxygen	69-77	complement C4A (Rodgers blood group)	Homo sapiens	217-220
24809065-0	2014	Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland.	Oxygen	8-14	insulin like growth factor binding protein 3	Homo sapiens	58-102
621277-7	1978	The percentage increases in oxygen uptake in response to histamine, gastrin, carbamylcholine, and IMX were similar in enriched fractions with from 50 to 85% parietal cells and in unenriched starting fractions.	Oxygen	28-34	gastrin	Homo sapiens	68-75
24809065-0	2014	Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland.	Oxygen	8-14	insulin like growth factor binding protein 3	Homo sapiens	104-110
621277-12	1978	These data indicate that in this in vitro system parietal cells account for most of the increase in oxygen uptake produced by exposure to gastric secretagogues and that histamine, gastrin, and carbamylcholine each independently stimulate oxygen uptake by the parietal cell.	Oxygen	238-244	gastrin	Homo sapiens	180-187
23934928-4	2014	Calcium ions function as bridges between several negatively charged residues of annexin V and the oxygen atoms of lipids.	Oxygen	98-104	annexin A5	Homo sapiens	80-89
621278-3	1978	In previous studies carbamylcholine, isobutyl methyl xanthine, gastrin, and histamine have each been shown to increase oxygen uptake by these cells.	Oxygen	119-125	gastrin	Homo sapiens	63-70
401372-1	1978	Myoglobin is the oxygen-binding protein characteristic of skeletal and cardiac muscle.	Oxygen	17-23	myoglobin	Homo sapiens	0-9
24497664-13	2014	The rhythm-adjusted mean levels of PAI-1 activity levels in the OSA group (23.9 IU/mL, 95% CI, 21.4 to 26.5) were also significantly higher than in the non-OSA group (17.2 IU/ mL, 95% CI, 14.6 to 19.9; P &lt; 0.001).There were strong correlations between amplitude of PAI-1 activity and severity of OSA as measured by AHI (P = 0.02), and minimum oxygen levels during sleep (P = 0.04).	Oxygen	346-352	serpin family E member 1	Homo sapiens	35-40
24489651-13	2014	Growth of cells in 1% O2 induced elevated HIF1alpha, BCRP and MDR-1 protein, and these cells were resistant to DOX.	Oxygen	22-24	BCR pseudogene 1	Homo sapiens	53-57
24475033-11	2014	Given that HIF-2alpha protein undergoes oxygen dependent degradation, an interesting possibility is that retinal blood vessels may regulate astrocyte differentiation through their oxygen delivery function.	Oxygen	40-46	endothelial PAS domain protein 1	Mus musculus	11-21
25335240-6	2014	The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.	Oxygen	168-174	Sirtuin 1	Drosophila melanogaster	301-305
24344663-7	2014	CT-1 was detected in all patients with levels negatively correlating to the arterial oxygen saturation.	Oxygen	85-91	cardiotrophin 1	Homo sapiens	0-4
24269895-1	2014	Bone marrow derived human mesenchymal stem cells (hMSC) are the primary cell type in bone tissue engineering, and their life span during osteogenic differentiation is associated with changes in oxygen tension.	Oxygen	194-200	musculin	Homo sapiens	50-54
24269895-2	2014	As a ubiquitous regulator of cellular metabolic activity, oxygen tension influences the profiles of metabolites in the entire metabolic network and plays an important role in hMSC survival, function, and osteogenic differentiation.	Oxygen	58-64	musculin	Homo sapiens	175-179
24269895-3	2014	In the current study, we hypothesize that hMSC have a metabolic phenotype that supports growth in low oxygen environments and that this phenotype changes upon differentiation, leading to differential responses to oxygen tension.	Oxygen	102-108	musculin	Homo sapiens	42-46
24269895-3	2014	In the current study, we hypothesize that hMSC have a metabolic phenotype that supports growth in low oxygen environments and that this phenotype changes upon differentiation, leading to differential responses to oxygen tension.	Oxygen	213-219	musculin	Homo sapiens	42-46
24475033-11	2014	Given that HIF-2alpha protein undergoes oxygen dependent degradation, an interesting possibility is that retinal blood vessels may regulate astrocyte differentiation through their oxygen delivery function.	Oxygen	180-186	endothelial PAS domain protein 1	Mus musculus	11-21
861221-0	1977	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	16-22	myoglobin	Homo sapiens	0-9
23318452-7	2014	Consequently, the toxic affects of aerobic metabolism on biogenesis and function of the ribosome are alleviated by YNL260c, hence, we rename YNL260c as LTO1; required for biogenesis of the large ribosomal subunit and initiation of translation in oxygen.	Oxygen	246-252	ribosome biosynthesis protein LTO1	Saccharomyces cerevisiae S288C	152-156
23318452-9	2014	Like Lto1, the Rli1/ABCE1 [4Fe-4S] clusters are not required for viability under anaerobic conditions, but are essential in the presence of oxygen.	Oxygen	140-146	ribosome biosynthesis protein LTO1	Saccharomyces cerevisiae S288C	5-9
24269895-6	2014	The results revealed contrasting metabolic profiles for hMSC and the hMSC-OS in both 20% and 2% O2 states, with the most significant differences involving coupling of glycolysis to the TCA cycle, glutaminolysis, and the malate-aspartate shuttle.	Oxygen	96-98	musculin	Homo sapiens	56-60
23744881-3	2014	In the 12-month-old male offspring of pregnant rat dams exposed to 11.5% atmospheric oxygen from gestational day (gd) 15 to gd 21, nonfasting glucose was lower in association with decreased hepatic G6Pase messenger RNA and protein levels.	Oxygen	85-91	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	198-204
23744881-5	2014	Moreover, when McA-RH7777 hepatoma cells were exposed to various concentrations of oxygen for 48 hours, we observed an oxygen-dependent decrease in G6Pase expression associated with enhanced histone H3 [K9] methylation.	Oxygen	83-89	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	148-154
861221-0	1977	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	16-22	myoglobin	Homo sapiens	96-105
23744881-5	2014	Moreover, when McA-RH7777 hepatoma cells were exposed to various concentrations of oxygen for 48 hours, we observed an oxygen-dependent decrease in G6Pase expression associated with enhanced histone H3 [K9] methylation.	Oxygen	119-125	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	148-154
24444333-4	2014	HIF-1beta is constantly expressed, whereas HIF-1alpha is degraded under normal oxygen conditions.	Oxygen	79-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	43-53
861221-0	1977	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	51-57	myoglobin	Homo sapiens	0-9
861221-0	1977	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	51-57	myoglobin	Homo sapiens	96-105
861221-2	1977	If the oxygen affinity of one myoglobin derivative is known, the oxygen affinity of the other can be determined from measurements at various oxygen partial pressures.	Oxygen	7-13	myoglobin	Homo sapiens	30-39
24253537-0	2014	Novel titanium-based O3-type NaTi(0.5)Ni(0.5)O2 as a cathode material for sodium ion batteries.	Oxygen	45-47	N-acetyltransferase 1	Homo sapiens	29-33
861221-2	1977	If the oxygen affinity of one myoglobin derivative is known, the oxygen affinity of the other can be determined from measurements at various oxygen partial pressures.	Oxygen	65-71	myoglobin	Homo sapiens	30-39
24253537-1	2014	O3-type NaTi(0.5)Ni(0.5)O2 is explored as a titanium-based cathode material for sodium ion batteries.	Oxygen	24-26	N-acetyltransferase 1	Homo sapiens	8-12
24117017-4	2014	In this study, we demonstrated that reduced oxygen tension increased CEMP1 expression, mineral deposition, and alkaline phosphatase activity in human dental stem cells such as PDL stem cells and periapical follicular stem cells.	Oxygen	44-50	cementum protein 1	Homo sapiens	69-74
861221-2	1977	If the oxygen affinity of one myoglobin derivative is known, the oxygen affinity of the other can be determined from measurements at various oxygen partial pressures.	Oxygen	65-71	myoglobin	Homo sapiens	30-39
861221-5	1977	Using protoheme myoglobin as an oxygen indicator, the oxygen pressure at half saturation (P 1/2) of mesoheme myoglobin was shown to be 11% higher than the P 1/2 of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	32-38	myoglobin	Homo sapiens	109-118
861221-5	1977	Using protoheme myoglobin as an oxygen indicator, the oxygen pressure at half saturation (P 1/2) of mesoheme myoglobin was shown to be 11% higher than the P 1/2 of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	32-38	myoglobin	Homo sapiens	109-118
24424315-2	2014	Lactoferrin (LF) was examined with regard to its potential role as a scavenger against radical oxygen species using bovine milk LF.	Oxygen	95-101	lactotransferrin	Bos taurus	0-11
861221-5	1977	Using protoheme myoglobin as an oxygen indicator, the oxygen pressure at half saturation (P 1/2) of mesoheme myoglobin was shown to be 11% higher than the P 1/2 of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	54-60	myoglobin	Homo sapiens	16-25
25206644-3	2013	Chemically synthesized small interfering RNA (siRNA)-1280, -1724 and -418 specific to toll-like receptor 3 were transfected into oxygen-glucose deprived cortical neurons to suppress the upregulation of toll-like receptor 3 protein expression.	Oxygen	129-135	toll-like receptor 3	Rattus norvegicus	86-106
24047466-8	2013	Sirt3(-/-) mice housed in chronic hypoxia (10% O2; 30 d) developed PH, PA wall remodeling, and right ventricular hypertrophy that was indistinguishable from Sirt3(+/+) littermates.	Oxygen	47-49	sirtuin 3	Mus musculus	0-5
23884959-2	2013	This study showed that pathological hypoxia (&lt;0.5% O2) increased the expression of androgen receptor (AR) target genes such as prostate-specific antigen (PSA) and kallikrein-related peptidase 2 in LNCaP human prostate cancer cells by modifying the quantity and activity of related Jumonji C domain-containing histone demethylases (JMJDs).	Oxygen	54-56	kallikrein related peptidase 3	Homo sapiens	130-155
24416337-3	2014	Previously we found that Sirtuin1 (Sirt1), a metabolically dependent protein deacetylase, regulates vascular regeneration in a mouse model of oxygen-induced proliferative retinopathy (OIR), as neuronal depletion of Sirt1 in retina worsens retinopathy.	Oxygen	142-148	sirtuin 1	Mus musculus	25-33
24416337-3	2014	Previously we found that Sirtuin1 (Sirt1), a metabolically dependent protein deacetylase, regulates vascular regeneration in a mouse model of oxygen-induced proliferative retinopathy (OIR), as neuronal depletion of Sirt1 in retina worsens retinopathy.	Oxygen	142-148	sirtuin 1	Mus musculus	35-40
24416337-3	2014	Previously we found that Sirtuin1 (Sirt1), a metabolically dependent protein deacetylase, regulates vascular regeneration in a mouse model of oxygen-induced proliferative retinopathy (OIR), as neuronal depletion of Sirt1 in retina worsens retinopathy.	Oxygen	142-148	sirtuin 1	Mus musculus	215-220
24729219-4	2014	Using electron paramagnetic resonance (EPR) to assess in vivo oxygen concentration in tumors repeatedly and non-invasively, we found that mNPH increased tumor pO2 from 3.5 to 68.8 mmHg on average for up to 10 days.	Oxygen	62-68	tensin 2	Mus musculus	138-142
861221-5	1977	Using protoheme myoglobin as an oxygen indicator, the oxygen pressure at half saturation (P 1/2) of mesoheme myoglobin was shown to be 11% higher than the P 1/2 of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	54-60	myoglobin	Homo sapiens	109-118
861221-5	1977	Using protoheme myoglobin as an oxygen indicator, the oxygen pressure at half saturation (P 1/2) of mesoheme myoglobin was shown to be 11% higher than the P 1/2 of a modified myoglobin derivative containing covalently bound mesoheme.	Oxygen	54-60	myoglobin	Homo sapiens	109-118
24127122-2	2013	PIP4K2B has been linked to the regulation of gene transcription, to TP53 and AKT activation, and to the regulation of cellular reactive oxygen accumulation.	Oxygen	136-142	phosphatidylinositol-5-phosphate 4-kinase type 2 beta	Homo sapiens	0-7
858638-3	1977	Hyperbaric oxygen treatment at 2-8 atm (approximately 290 kPa) prevented the development of gangrene in all cases.	Oxygen	11-17	ATM serine/threonine kinase	Homo sapiens	21-24
24244514-6	2013	Our results demonstrate that exposure to hypoxia (10% O2) for 3-weeks increased levels of miR-27a and ET-1 in the lungs of C57BL/6 mice and reduced PPARgamma levels.	Oxygen	54-56	endothelin 1	Mus musculus	102-106
25323790-9	2014	CONCLUSION: Inhibition of HIF-2alpha protein reversed lipid metabolism dysregulation induced by acute hypoxia in HepG2 cells, which suggested that HIF-2alpha signaling may be relevant to oxygen-dependent lipid homeostasis in the liver.	Oxygen	187-193	endothelial PAS domain protein 1	Homo sapiens	26-36
24166752-6	2014	At 16 weeks, hearts from O(2)-exposed rats showed cardiomyocyte hypertrophy, enhanced fibrosis, and increased expression of transforming growth factor-beta1, senescence-associated proteins p53 and Rb, upregulation of angiotensin II type 1 (AT1) receptor expression (protein and AT1a/b mRNA), and downregulation of AT2 receptors.	Oxygen	25-29	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	189-192
24166752-7	2014	At 4 weeks (before blood pressure increase), the expression of cardiomyocyte surface area, fibrosis, p53, and AT1b was significantly increased and AT2 decreased in O(2)-exposed animals.	Oxygen	164-168	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	101-104
24269895-6	2014	The results revealed contrasting metabolic profiles for hMSC and the hMSC-OS in both 20% and 2% O2 states, with the most significant differences involving coupling of glycolysis to the TCA cycle, glutaminolysis, and the malate-aspartate shuttle.	Oxygen	96-98	musculin	Homo sapiens	69-73
863812-1	1977	Seven men ran at 60% of individual maximal oxygen uptake to exhaustion during beta-adrenergic blockade with propranolol or without drugs.	Oxygen	43-49	RAN, member RAS oncogene family	Homo sapiens	10-13
24126963-3	2014	Blood volume and concentrations of blood hemoglobin and muscle myoglobin are elevated and serve as a significant oxygen store that increases aerobic dive duration.	Oxygen	113-119	myoglobin	Homo sapiens	63-72
24126963-4	2014	However, myoglobin is not homogeneously distributed in the locomotory muscles and is highest in areas that produce greater force and consume more oxygen during aerobic swimming.	Oxygen	146-152	myoglobin	Homo sapiens	9-18
23884884-12	2013	In summary, a decrease in ATP7A protein expression contributes to impaired SOD3 activity, resulting in O2( -) overproduction and endothelial dysfunction in blood vessels of T1DM.	Oxygen	103-105	superoxide dismutase 3, extracellular	Mus musculus	75-79
23913859-7	2013	Moreover, using a murine treatment model of bleomycin-induced pulmonary fibrosis we found that inhibition of TGFbeta/PDGF and ErbB pathways with imatinib plus lapatinib, respectively, not only prevented myofibroblast gene expression to a greater extent than either drug alone, but also essentially stabilized gas exchange (oxygen saturation) as an overall measure of lung function.	Oxygen	323-329	epidermal growth factor receptor	Mus musculus	126-130
323723-0	1977	Evidence from oxygen exchange measurements for a cooperative interaction between the two heads of myosin.	Oxygen	14-20	myosin heavy chain 14	Homo sapiens	98-104
23954363-10	2013	The percentage of cFOS-activated AgRP neurons per total AgRP cells was lower in H cows and correlated negatively with oxygen consumption and NEFA, positively with RQ, but not with feed intake.	Oxygen	118-124	agouti-related protein	Bos taurus	33-37
23954363-10	2013	The percentage of cFOS-activated AgRP neurons per total AgRP cells was lower in H cows and correlated negatively with oxygen consumption and NEFA, positively with RQ, but not with feed intake.	Oxygen	118-124	agouti-related protein	Bos taurus	56-60
24583842-5	2014	P4 production by non-luteinizing granulosa cells was not affected by hypoxia (24 h at 10% and 5% O2), while P4 production by granulosa cells treated with insulin in combination with forskolin was significantly increased under hypoxia (24 h at 10% and 5% O2).	Oxygen	254-256	insulin	Bos taurus	154-161
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	235-237	insulin	Bos taurus	26-33
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	235-237	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	Bos taurus	168-202
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	235-237	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	Bos taurus	204-213
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	346-348	insulin	Bos taurus	26-33
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	346-348	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	Bos taurus	168-202
24583842-7	2014	In the cells treated with insulin in combination with forskolin, mRNA and protein expression of steroidogenic acute regulatory protein (StAR) and protein expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) increased under 10% O2, while mRNA and protein expressions of key protein and enzymes in P4 biosynthesis did not increase under 5% O2.	Oxygen	346-348	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	Bos taurus	204-213
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	calcineurin like EF-hand protein 1	Homo sapiens	183-186
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	pleckstrin	Homo sapiens	236-239
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	aquaporin 4	Rattus norvegicus	48-59
24061475-9	2013	Moreover, oxygen deprivation destabilizes PHLPP protein by decreasing the expression of USP46, a deubiquitinase of PHLPP.	Oxygen	10-16	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	42-47
24061475-9	2013	Moreover, oxygen deprivation destabilizes PHLPP protein by decreasing the expression of USP46, a deubiquitinase of PHLPP.	Oxygen	10-16	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	115-120
23872453-8	2013	In addition, the Pc-2 molecule was found to be the most efficient singlet oxygen generator from the group of macrocycles studied.	Oxygen	74-80	chromobox 4	Homo sapiens	17-21
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	aquaporin 4	Rattus norvegicus	61-65
66306-0	1977	Orientation of the oxygen atom at C-6 as a determinant of agonistic activity in the oxymorphone series.	Oxygen	19-25	complement component C6	Cavia porcellus	34-37
24170091-5	2013	Here we aimed to investigate the phosphorylation alteration of DYNLT1 at serine 82 (S82) in hypoxia (1% O2).	Oxygen	104-106	dynein light chain Tctex-type 1	Homo sapiens	63-69
24252224-6	2014	Effects of oxygen on neurosphere expression of hypoxia inducible factor 1, alpha subunit (HIF1A) and its target genes, erythropoietin receptor (EPOR), chemokine (C-X-C motif) receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF), were quantified by qPCR.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	90-95
66306-2	1977	Substitution of the oxygen at C-6 by amethylene group slightly increased antagonistic activity of the resulting structures, without significantly influencing agonistic activity relative to the parent compound.	Oxygen	20-26	complement component C6	Cavia porcellus	30-33
24252224-10	2014	Neurospheres cultured in 1% O2 had significantly increased levels of VEGF and EPOR.	Oxygen	28-30	erythropoietin receptor	Canis lupus familiaris	78-82
845508-1	1977	An important role of myoglobin in red muscle is to facilitate the diffusion of oxygen for metabolism.	Oxygen	79-85	myoglobin	Homo sapiens	21-30
24252224-11	2014	There was a significant increase in CXCR4 expression in neurospheres generated at all O2 tensions.	Oxygen	86-88	C-X-C motif chemokine receptor 4	Canis lupus familiaris	36-41
24304513-3	2013	The transketolase-like protein 1 (TKTL1) represents the enzymatic basis for an anaerobic glucose metabolism even in the presence of oxygen (aerobic glycolysis/Warburg effect), which is concomitant with a more malignant phenotype due to invasive growth/metastasis and resistance to radical and apoptosis inducing therapies.	Oxygen	132-138	transketolase like 1	Homo sapiens	4-32
24033131-2	2013	Compounds 1 and 2 are the first examples of clerodane diterpenoids with an oxygen bridge between C-2 and C-19, and compounds 5-7 are three new diterpenoid artifacts presumably formed during the extraction process.	Oxygen	75-81	complement C2	Homo sapiens	97-100
837249-4	1977	Superoxide dismutase (EC 1.15.1.1) or anaerobiosis inhibited the reduction of cytochrome c by the enzyme only to the extent of 25-35%, indicating the existence of a direct reduction of cytochrome c by the enzyme without involving O2-.	Oxygen	230-232	cytochrome c, somatic	Equus caballus	78-90
24058604-10	2013	Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships.	Oxygen	152-158	serine/threonine kinase 39	Mus musculus	86-90
24058604-10	2013	Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships.	Oxygen	152-158	serine/threonine kinase 39	Mus musculus	113-117
24058604-10	2013	Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships.	Oxygen	152-158	solute carrier family 12, member 5	Mus musculus	122-126
24058604-10	2013	Using co-immunoprecipitation, we determined that the intensity of interaction between SPAK and NKCC1 and between SPAK and KCC2 increased markedly after oxygen-deprivation, whereas SPAK overexpression strengthened the relationships.	Oxygen	152-158	serine/threonine kinase 39	Mus musculus	113-117
24304513-3	2013	The transketolase-like protein 1 (TKTL1) represents the enzymatic basis for an anaerobic glucose metabolism even in the presence of oxygen (aerobic glycolysis/Warburg effect), which is concomitant with a more malignant phenotype due to invasive growth/metastasis and resistance to radical and apoptosis inducing therapies.	Oxygen	132-138	transketolase like 1	Homo sapiens	34-39
23880643-9	2013	Fifteen cytokines/chemokines including Type 2 cytokines IL-13, MCP-1, and CD40 ligand were detected in ambient O2 ASC medium.	Oxygen	111-113	C-C motif chemokine ligand 2	Homo sapiens	63-68
837249-4	1977	Superoxide dismutase (EC 1.15.1.1) or anaerobiosis inhibited the reduction of cytochrome c by the enzyme only to the extent of 25-35%, indicating the existence of a direct reduction of cytochrome c by the enzyme without involving O2-.	Oxygen	230-232	cytochrome c, somatic	Equus caballus	185-197
23902766-0	2013	Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption.	Oxygen	153-159	matrix metallopeptidase 1	Homo sapiens	0-32
23902766-7	2013	MLE12 cells expressing human MMP-1 showed a significant repression of oxygen consumption ratio compared with the cells with the empty vector.	Oxygen	70-76	matrix metallopeptidase 1	Homo sapiens	29-34
23902766-11	2013	Paralleling these findings, attenuation of MMP-1 expression by shRNA in A549 (human) AECs markedly reduced proliferation and migration (p &lt; 0.01) and increased the oxygen consumption ratio.	Oxygen	167-173	matrix metallopeptidase 1	Homo sapiens	43-48
23961832-0	2013	Electrocatalytic O2 reduction reaction by synthetic analogues of cytochrome P450 and myoglobin: in-situ resonance Raman and dynamic electrochemistry investigations.	Oxygen	17-19	myoglobin	Homo sapiens	85-94
182267-6	1976	The possibility that the sixth, symmetry-decreasing ligand is the oxygen molecule is excluded by the chemistry of the system and by the EPR properties of previously reported cob(II)alamins.	Oxygen	66-72	metabolism of cobalamin associated B	Homo sapiens	174-177
23816886-0	2013	MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.	Oxygen	26-28	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
23816886-6	2013	Increased MYC turnover at low O2 tension was dependent on the E3 ubiquitin ligases FBXW7 and DDB1, as well as hypoxic induction of cathepsins D and S. Reduced MYC protein levels coincided with hypoxic inhibition of RNA polymerase III-dependent MYC target genes, which MYC regulates independently of its binding partner MAX.	Oxygen	30-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	10-13
23816886-8	2013	Collectively, these results indicate that hypoxic cells promote MYC degradation as an adaptive strategy to reduce proliferation, suppress biosynthetic processes, and promote cell survival under low O2 tension.	Oxygen	198-200	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-67
937780-0	1976	The effect of myoglobin on the oxygen concentration in skeletal muscle subjected to ischemia.	Oxygen	31-37	myoglobin	Homo sapiens	14-23
23689258-4	2013	A proteomic experiment identified 23 proteins presenting a differential abundance in lto1-2 compared with wild-type plants, including components in PSII and proteins scavenging active oxygen.	Oxygen	184-190	NAD(P)H dehydrogenase (quinone)s	Arabidopsis thaliana	85-89
23689258-5	2013	Three scavengers of active oxygen, L-ascorbate peroxidase 1, peroxisomal catalase 2, dehydroascorbate reductase 1, are reduced in lto1-2 plants, corresponding to high levels of accumulation of reactive oxygen species (ROS).	Oxygen	27-33	NAD(P)H dehydrogenase (quinone)s	Arabidopsis thaliana	130-134
1015406-0	1976	Facilitated diffusion of CO and oxygen in the presence of hemoglobin or myoglobin.	Oxygen	32-38	myoglobin	Homo sapiens	72-81
23932902-0	2013	PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.	Oxygen	37-43	centrosomal protein 192	Homo sapiens	101-107
1191643-1	1975	Myoglobin rebinding of carbon monoxide and dioxygen after photodissociation has been observed in the temperature range between 40 and 350 K. A system was constructed that records the change in optical absorption at 436 nm smoothly and without break between 2 musec and 1 ksec.	Oxygen	43-51	myoglobin	Homo sapiens	0-9
23545069-3	2013	The SMBR was operated at a filtration flux of 20 L/m(2)h. The removal of dissolved organic carbon (DOC) and chemical oxygen demand (COD) with the addition of GAC was 95%.	Oxygen	117-123	glutaminase	Homo sapiens	158-161
1191655-1	1975	The inhibitory effect of the Cd2+ in the electron transport of the isolated chloroplasts has been observed by measuring the oxygen uptake from the solution and the fluorescence induction.	Oxygen	124-130	CD2 molecule	Homo sapiens	29-32
23759948-7	2013	Furthermore, TERE1 expression increased mitochondrial oxygen consumption and hydrogen production, oxidative stress and NO production.	Oxygen	54-60	UbiA prenyltransferase domain containing 1	Homo sapiens	13-18
236172-5	1975	Reduced oxygen consumption and decreased carbon dioxide production by the bone showed that CT acted by inhibiting the metabolic activity of bone cells in vivo.	Oxygen	8-14	calcitonin	Canis lupus familiaris	91-93
23293077-8	2013	PC3 tumors were less hypoxic at baseline, and their response to carbogen dominated by increased dissolved oxygen, evidenced by highly positive DeltaR(1) .	Oxygen	106-112	chromobox 8	Homo sapiens	0-3
237516-6	1975	On average, increasing the inspired concentration of oxygen to 50 per cent significantly and substantially increased maternal PsO2 with both agents by the emd pf inhalation.	Oxygen	53-59	DNA cross-link repair 1A	Homo sapiens	126-130
23770211-8	2013	Inhibition of PKCbetaII rescued glucose toxicity-induced generation of ROS and O2(-), apoptosis, cell death and mitochondrial injury (reduced aconitase activity, UCP-2 and PGC-1alpha).	Oxygen	79-81	phospholipase C, beta 2	Rattus norvegicus	14-23
1115724-2	1975	At 4,575 m (15,000 ft) and 3.65 1/min oxygen flow, calculated fractional inspired oxygen (F102) averaged 38.1% for the Hudson-type mask; 49.6% for the Scott Sky Mask; and 52.4% for the Scott Duo Seal Mask.	Oxygen	82-88	ankyrin repeat and KH domain containing 1	Homo sapiens	131-135
23858469-0	2013	Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease.	Oxygen	0-6	lon peptidase 1, mitochondrial	Homo sapiens	87-99
1115724-7	1975	The respiratory mass spectrometer provides a new technique for analyzing efficiency of oxygen masks and the effect of changes in mask design.	Oxygen	87-93	ankyrin repeat and KH domain containing 1	Homo sapiens	94-98
23858469-8	2013	Mitochondrial accumulation of heme oxygenase-1, another heme protein, was also regulated by oxygen level and Lon protease in the same mechanism as for CBS.	Oxygen	35-41	lon peptidase 1, mitochondrial	Homo sapiens	109-112
1112119-3	1975	These data suggest that, after discontinuing supplemental oxygen in patients with chronic airways obstruction, more than 25 minutes should elapse if a blood gas measurement is to reflect with certainty conditions during room air breathing.	Oxygen	58-64	gastrin	Homo sapiens	157-160
23882269-9	2013	Under both oxygen levels ASC were capable of strong upregulation of the immunomodulatory molecules indoleamine 2,3-dioxygenase (IDO) and programed death ligand-1 upon stimulation with IFN-gamma and TNF-alpha, and, in addition, IDO activity as measured by the accumulation of l-kynurenine was not affected under hypoxia.	Oxygen	11-17	indoleamine 2,3-dioxygenase 1	Homo sapiens	99-126
1133823-2	1975	A careful examination of the resulting 1,2-disubstituted 7-aminomitosenes indicated that there was a strong tendency for the azridine ring on opening to furnish mainly one stereoisomer, always with the oxygen stom at C-1 and the nitrogen atom at C-2.	Oxygen	202-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	217-220
23874449-0	2013	Structural modulation of brain development by oxygen: evidence on adolescents migrating from high altitude to sea level environment.	Oxygen	46-52	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	110-113
23847542-2	2013	Using two indicators of metabolic rate, oxygen consumption was significantly lower in leptin morphants early in development [&lt;48 hours post-fertilization (hpf)], while acid production was significantly lower in morphants later in development (&gt;48 hpf).	Oxygen	40-46	leptin a	Danio rerio	86-92
23847542-3	2013	Oxygen utilization rates in &lt;48 hpf embryos and acid production in 72 hpf embryos could be rescued to that of wildtype embryos by recombinant leptin coinjected with antisense morpholino.	Oxygen	0-6	leptin a	Danio rerio	145-151
23523698-7	2013	In vitro erythropoietin treatment of primary skeletal myoblasts increased mitochondrial biogenesis gene expression including PGC-1alpha by 2.6-fold, CytC by 2-fold, oxygen consumption rate by 2-fold, and citrate synthase activity by 58%.	Oxygen	165-171	erythropoietin	Mus musculus	9-23
23495787-4	2013	The device tip releases stored pheophorbide by attack of singlet oxygen from sensitized oxygen gas delivered through the hollow fiber using 669 nm laser light.	Oxygen	65-71	TOR signaling pathway regulator	Homo sapiens	11-14
23394201-8	2013	Results show a downregulation of the osteogenic markers (ALP activity, mineralization, ON, OPN) in both 1% and 2% O2 when compared to 20% O2 in both 2-D and 3-D culture.	Oxygen	114-116	secreted phosphoprotein 1	Homo sapiens	91-94
23805218-10	2013	Co-overexpression of SelR and Clu in N2aSW cells, an AD model cell line, significantly decreased the level of intracellular reactive oxygen species.	Oxygen	133-139	clusterin	Mus musculus	30-33
23840631-9	2013	In a model of O2-induced arrested alveolar growth in newborn rats mimicking BPD, air space enlargement was associated with decreased lung Sema3C mRNA expression.	Oxygen	14-16	semaphorin 3C	Rattus norvegicus	138-144
23665013-0	2013	Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera.	Oxygen	0-6	hepcidin antimicrobial peptide	Homo sapiens	42-50
23665013-8	2013	Treatment of hepcidin-GFP expressing cells with hypoxia (0.1% O2) altered the subcellular distribution of pro-hepcidin-GFP and significantly reduced the secretion of mature hepcidin-GFP.	Oxygen	62-64	hepcidin antimicrobial peptide	Homo sapiens	13-21
23665013-8	2013	Treatment of hepcidin-GFP expressing cells with hypoxia (0.1% O2) altered the subcellular distribution of pro-hepcidin-GFP and significantly reduced the secretion of mature hepcidin-GFP.	Oxygen	62-64	hepcidin antimicrobial peptide	Homo sapiens	110-118
23665013-8	2013	Treatment of hepcidin-GFP expressing cells with hypoxia (0.1% O2) altered the subcellular distribution of pro-hepcidin-GFP and significantly reduced the secretion of mature hepcidin-GFP.	Oxygen	62-64	hepcidin antimicrobial peptide	Homo sapiens	110-118
23564640-5	2013	METHODS AND RESULTS: Studies of cultured ECs demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 mitogen-activated protein kinase-dependent transcriptional and post-transcriptional mechanisms.	Oxygen	75-81	OTU domain containing 7B	Mus musculus	91-98
23857304-3	2013	Myoglobin contributes to intracellular oxygen storage and transcellular diffusion of oxygen in muscle, and plays an important role in supplying oxygen in hypoxic or ischemic conditions.	Oxygen	39-45	myoglobin	Homo sapiens	0-9
23857304-3	2013	Myoglobin contributes to intracellular oxygen storage and transcellular diffusion of oxygen in muscle, and plays an important role in supplying oxygen in hypoxic or ischemic conditions.	Oxygen	85-91	myoglobin	Homo sapiens	0-9
23857304-3	2013	Myoglobin contributes to intracellular oxygen storage and transcellular diffusion of oxygen in muscle, and plays an important role in supplying oxygen in hypoxic or ischemic conditions.	Oxygen	85-91	myoglobin	Homo sapiens	0-9
23862489-4	2013	A dry oxidation process using only oxygen without hydrogen and oxidation for logic gates led to the formation of a sacrificial oxide on the rapid thermal oxidation (RTP) methods without densification after gap-filling as reducing dislocation processes.	Oxygen	35-41	MORN repeat containing 4	Homo sapiens	165-168
23625637-11	2013	Using an in silico approach based on the crystal structure of wild-type p53 protein, substitution of proline by serine at position 151 would create a cavity in a hydrophobic pocket, the loss of van der Waals contacts, and the thermodynamically unfavorable placement of a polar group, the hydroxyl oxygen atom of the serine, within a hydrophobic region, all of which likely cause a locally altered structure.	Oxygen	297-303	transformation related protein 53	Mus musculus	72-75
23378030-0	2013	Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.	Oxygen	78-84	sonic hedgehog signaling molecule	Homo sapiens	0-14
23378030-0	2013	Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.	Oxygen	78-84	sonic hedgehog signaling molecule	Homo sapiens	16-19
23675474-0	2013	Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions.	Oxygen	30-36	indoleamine 2,3-dioxygenase 1	Homo sapiens	14-17
23675474-6	2013	We therefore analysed IDO-mediated effects under lower oxygen concentrations in vitro and observed that the function of IDO is substantially impaired in tumour cells as well as in native cells.	Oxygen	55-61	indoleamine 2,3-dioxygenase 1	Homo sapiens	22-25
23675474-6	2013	We therefore analysed IDO-mediated effects under lower oxygen concentrations in vitro and observed that the function of IDO is substantially impaired in tumour cells as well as in native cells.	Oxygen	55-61	indoleamine 2,3-dioxygenase 1	Homo sapiens	120-123
23610397-0	2013	Mutual antagonism between hypoxia-inducible factors 1alpha and 2alpha regulates oxygen sensing and cardio-respiratory homeostasis.	Oxygen	80-86	hypoxia inducible factor 1, alpha subunit	Mus musculus	26-69
23512331-2	2013	Further synthetic elaborations revealed a remarkable difference in the reactivity of cis-1-tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine with respect to aromatic sulfur and oxygen nucleophiles, thus enabling the selective deployment of this versatile substrate as a building block for the synthesis of functionalized aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines.	Oxygen	179-185	suppressor of cytokine signaling 1	Homo sapiens	85-90
23376624-0	2013	Myoglobin-dependent O2 consumption of the hypoxic trout heart.	Oxygen	20-22	myoglobin	Homo sapiens	0-9
23376624-1	2013	Myoglobin (Mb) plays a well-established role in facilitated O2 diffusion to sustain mitochondrial O2 consumption during hypoxia in the mammalian heart.	Oxygen	60-62	myoglobin	Homo sapiens	0-9
23376624-1	2013	Myoglobin (Mb) plays a well-established role in facilitated O2 diffusion to sustain mitochondrial O2 consumption during hypoxia in the mammalian heart.	Oxygen	60-62	myoglobin	Homo sapiens	11-13
23376624-1	2013	Myoglobin (Mb) plays a well-established role in facilitated O2 diffusion to sustain mitochondrial O2 consumption during hypoxia in the mammalian heart.	Oxygen	98-100	myoglobin	Homo sapiens	0-9
23376624-1	2013	Myoglobin (Mb) plays a well-established role in facilitated O2 diffusion to sustain mitochondrial O2 consumption during hypoxia in the mammalian heart.	Oxygen	98-100	myoglobin	Homo sapiens	11-13
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Oxygen	68-74	endothelial PAS domain protein 1	Homo sapiens	4-9
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Oxygen	68-74	endothelial PAS domain protein 1	Homo sapiens	110-119
23628342-6	2013	Both Saccharomyces cerevisiae cdt-1 and Candida molischiana "protect" C. phytofermentans from introduced oxygen in return for soluble sugars released by C. phytofermentans hydrolysis.	Oxygen	105-111	Tah11p	Saccharomyces cerevisiae S288C	30-35
23628342-8	2013	Using controlled oxygen delivery by diffusion through neoprene tubing at a calculated rate of approximately 8 mumol/L hour, we demonstrate establishment of the symbiotic relationship between C. phytofermentans and S. cerevisiae cdt-1 and maintenance of populations of 105 to 106 CFU/mL for 50 days.	Oxygen	17-23	Tah11p	Saccharomyces cerevisiae S288C	228-233
23503170-2	2013	Electron irradiation induced an in-gap state (IGS) as observed by UPS keeping the surface 1 x 1, which is considered to originate from oxygen vacancies on the topmost surface due to the electron-stimulated desorption (ESD) of oxygen.	Oxygen	135-141	regenerating family member 3 alpha	Homo sapiens	32-38
23503170-2	2013	Electron irradiation induced an in-gap state (IGS) as observed by UPS keeping the surface 1 x 1, which is considered to originate from oxygen vacancies on the topmost surface due to the electron-stimulated desorption (ESD) of oxygen.	Oxygen	226-232	regenerating family member 3 alpha	Homo sapiens	32-38
23467384-4	2013	HO  is the main active oxygen specie in benzyl alcohol selective oxidative reaction confirmed by terephthalic acid photoluminescence probing assay (TA-PL), selecting toluene as the substrate.	Oxygen	23-29	ATP binding cassette subfamily B member 9	Homo sapiens	148-153
23379999-1	2013	Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF).	Oxygen	28-34	vascular endothelial growth factor A	Rattus norvegicus	288-292
23386615-2	2013	Using two independent protein interaction screens, we show that these kinases associate, in an oxidation-dependent manner, with Prdx1, an enzyme that regulates the cellular redox state by reducing hydrogen peroxide to water and oxygen.	Oxygen	228-234	peroxiredoxin 1	Homo sapiens	128-133
23441886-3	2013	To further ascertain the correlation between O/M ratio and oxygen potential in Am-bearing MOX, several thermodynamic descriptions are being developed.	Oxygen	59-65	monooxygenase DBH like 1	Homo sapiens	90-93
24161936-4	2013	If the arterial partial pressure of oxygen (PaO2) is more than 10.7 kPa when breathing room air, HPS can be excluded and no other investigation is needed.	Oxygen	36-42	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	97-100
23686552-7	2013	Under oxygen stress a dose-dependent effect of UCHL1 was detected, which was mediated by a dynamic modification of the PI3K-Akt signaling.	Oxygen	6-12	ubiquitin specific peptidase 1	Homo sapiens	47-52
23964116-8	2013	Interestingly, GM-CSF and inflammatory CM increased neutrophil survival significantly, even at 1% oxygen, with cells remaining functionally active at 96 h. Dexamethasone was able to reduce the prosurvival effect of GM-CSF and inflammatory CM in a hypoxic environment.	Oxygen	98-104	colony stimulating factor 2	Homo sapiens	15-21
23775726-5	2013	Ischemic stress was shown to increase the levels of SUMO conjugation, especially SUMO-2/3, mostly during reperfusion in animal models and during restoration of oxygen and glucose in cell culture systems.	Oxygen	160-166	small ubiquitin-related modifier 2	Ictidomys tridecemlineatus	81-89
32261236-3	2013	Analysis revealed that the Gd3+ ions are surrounded by ~9 oxygen ions in the first coordination sphere with ~3 O2- ions and ~6 O2- ions, respectively, centered around 2.24 A and 2.41 A and that the Gd3+-ion sites in the GNTs are small.	Oxygen	58-64	GRDX	Homo sapiens	27-30
32261236-3	2013	Analysis revealed that the Gd3+ ions are surrounded by ~9 oxygen ions in the first coordination sphere with ~3 O2- ions and ~6 O2- ions, respectively, centered around 2.24 A and 2.41 A and that the Gd3+-ion sites in the GNTs are small.	Oxygen	58-64	GRDX	Homo sapiens	198-201
32261236-3	2013	Analysis revealed that the Gd3+ ions are surrounded by ~9 oxygen ions in the first coordination sphere with ~3 O2- ions and ~6 O2- ions, respectively, centered around 2.24 A and 2.41 A and that the Gd3+-ion sites in the GNTs are small.	Oxygen	111-113	GRDX	Homo sapiens	27-30
32261236-3	2013	Analysis revealed that the Gd3+ ions are surrounded by ~9 oxygen ions in the first coordination sphere with ~3 O2- ions and ~6 O2- ions, respectively, centered around 2.24 A and 2.41 A and that the Gd3+-ion sites in the GNTs are small.	Oxygen	127-129	GRDX	Homo sapiens	27-30
24062309-6	2013	Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8.	Oxygen	21-27	interleukin 1 alpha	Homo sapiens	49-58
23948708-7	2013	Moreover, by double affinity chromatography and subsequent analysis with mass spectrometry, we identified in the heat shock protein 90-alpha (HSP90alpha) a good candidate as carrier of the Galbeta1-3GalNAc epitope at low oxygen tension.	Oxygen	221-227	heat shock protein 90 alpha family class A member 1	Homo sapiens	142-152
23884884-5	2013	Here we show that the specific activity of SOD3, but not SOD1, is decreased, which is associated with increased O2( -) production in aortas of streptozotocin-induced and genetically induced Ins2(Akita) T1DM mice.	Oxygen	112-114	superoxide dismutase 3, extracellular	Mus musculus	43-47
23589166-7	2013	All of these iPS colonies that expanded under the various oxygen conditions stained positively for Oct3/4, Nanog, SSEA-4, and ALP.	Oxygen	58-64	POU class 5 homeobox 1	Homo sapiens	99-105
24022223-3	2013	Hypoxia is known to produce an enhanced angiogenic response and heightened levels of VEGF-A have been seen in oxygen deprived epithelial and endothelial cells, yet the pathways for VEGF-A signaling in BM-EPCs have not been described.	Oxygen	110-116	vascular endothelial growth factor A	Rattus norvegicus	85-91
24051248-3	2013	Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice.	Oxygen	272-278	sirtuin 3	Mus musculus	41-79
24051248-3	2013	Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice.	Oxygen	272-278	sirtuin 3	Mus musculus	81-86
23746540-4	2013	RESULTS: We demonstrate an association of ADHD symptoms with distinct blood oxygen level-dependent (BOLD) responses depending on MAOA genotype.	Oxygen	76-82	monoamine oxidase A	Homo sapiens	129-133
24417928-4	2013	The serum concentrations of HIF-1alpha and HIF-2alpha were measured with enzyme-linked immunosorbent assay (ELISA) to analyze the correlations of HIF-1alpha and HIF-2alpha with arterial partial pressure of oxygen (PaO2) and hemoglobin (Hb).	Oxygen	206-212	endothelial PAS domain protein 1	Homo sapiens	161-171
24023068-3	2013	Here we show that in bone-resorbing osteoclasts, estrogen-dependent destabilization of hypoxia-inducible factor 1 alpha (HIF1alpha), which is unstable in the presence of oxygen, plays a pivotal role in promoting bone loss in estrogen-deficient conditions.	Oxygen	170-176	hypoxia inducible factor 1, alpha subunit	Mus musculus	87-119
24023068-3	2013	Here we show that in bone-resorbing osteoclasts, estrogen-dependent destabilization of hypoxia-inducible factor 1 alpha (HIF1alpha), which is unstable in the presence of oxygen, plays a pivotal role in promoting bone loss in estrogen-deficient conditions.	Oxygen	170-176	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-130
24116043-7	2013	Also, in a mutant strain that only contains demethylmenaquinone, the extent of ArcA phosphorylation can be modulated by the oxygen supply rate, which shows that demethylmenaquinone can also inactivate ArcB in its oxidized form.	Oxygen	124-130	hypothetical protein	Escherichia coli	201-205
24116043-9	2013	Therefore, at low rates of oxygen supply in the wild type strain, the activity of ArcB may be inhibited by demethylmenaquinone, in spite of the fact that the ubiquinones are present in the ubiquinol form.	Oxygen	27-33	hypothetical protein	Escherichia coli	82-86
23860500-4	2013	METHODS: Acute colitis was induced by administration of Citrobacter rodentium or dextran sulfate sodium (DSS) to transgenic hypoxia reporter mice (oxygen-dependent degradation-luciferase), mice with conditional overexpression of Epas1 (Epas1(LSL/LSL)), mice with intestinal epithelium-specific deletion of Epas1 (Epas1(DeltaIE) ), or wild-type littermates (controls).	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	229-234
23860500-4	2013	METHODS: Acute colitis was induced by administration of Citrobacter rodentium or dextran sulfate sodium (DSS) to transgenic hypoxia reporter mice (oxygen-dependent degradation-luciferase), mice with conditional overexpression of Epas1 (Epas1(LSL/LSL)), mice with intestinal epithelium-specific deletion of Epas1 (Epas1(DeltaIE) ), or wild-type littermates (controls).	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	236-241
23860500-4	2013	METHODS: Acute colitis was induced by administration of Citrobacter rodentium or dextran sulfate sodium (DSS) to transgenic hypoxia reporter mice (oxygen-dependent degradation-luciferase), mice with conditional overexpression of Epas1 (Epas1(LSL/LSL)), mice with intestinal epithelium-specific deletion of Epas1 (Epas1(DeltaIE) ), or wild-type littermates (controls).	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	236-241
23860500-4	2013	METHODS: Acute colitis was induced by administration of Citrobacter rodentium or dextran sulfate sodium (DSS) to transgenic hypoxia reporter mice (oxygen-dependent degradation-luciferase), mice with conditional overexpression of Epas1 (Epas1(LSL/LSL)), mice with intestinal epithelium-specific deletion of Epas1 (Epas1(DeltaIE) ), or wild-type littermates (controls).	Oxygen	147-153	endothelial PAS domain protein 1	Mus musculus	313-327
23928310-3	2013	It is thus worth reconsidering from an evolutionary perspective how heme-bound proteins with a globin fold similar to that of hemoglobin and myoglobin could act as O2 sensors.	Oxygen	164-166	myoglobin	Homo sapiens	141-150
23747468-4	2013	Fe/Al-Lap catalysts showed high catalytic activities in the temperature range of 120-200  C without the presence of excessive O2.	Oxygen	126-128	LAP	Homo sapiens	6-9
23977880-4	2013	The catalytic activity of Ru1-xVxO2 for oxygen and H2O2 reduction at neutral pH increases as the fraction of vanadium increases within our experimental conditions, which might be useful in the area of biofuel cells and biosensors.	Oxygen	40-46	Scm like with four mbt domains 1	Homo sapiens	26-29
24040106-0	2013	SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.	Oxygen	114-120	putative glucosidase SUN4	Saccharomyces cerevisiae S288C	20-25
24040106-0	2013	SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.	Oxygen	114-120	SUN family protein UTH1	Saccharomyces cerevisiae S288C	27-32
24040106-3	2013	Here we show that three of the four Saccharomyces cerevisiae SUN family proteins, Uth1p, Sim1p and Sun4p, are efficiently secreted out of the cells in different growth phases and their production is affected by the level of oxygen.	Oxygen	224-230	SUN family protein UTH1	Saccharomyces cerevisiae S288C	82-87
24040106-3	2013	Here we show that three of the four Saccharomyces cerevisiae SUN family proteins, Uth1p, Sim1p and Sun4p, are efficiently secreted out of the cells in different growth phases and their production is affected by the level of oxygen.	Oxygen	224-230	putative glucosidase SUN4	Saccharomyces cerevisiae S288C	99-104
23972394-3	2013	By using a relevant ROP model, the 50/10 oxygen-induced retinopathy (OIR) model, we previously found that broad inhibition of VEGFA bioactivity using a neutralizing antibody to rat VEGF significantly reduced IVNV area compared with control IgG but also significantly reduced body weight gain in the pups, suggesting an adverse effect.	Oxygen	41-47	vascular endothelial growth factor A	Rattus norvegicus	126-131
23128156-3	2013	Synthesized MACF hydrogels were tested for their ability to takeup and then release oxygen for future use in dermal wound healing.	Oxygen	84-90	microtubule actin crosslinking factor 1	Homo sapiens	12-16
23128156-7	2013	MACF hydrogels proved to be readily reloaded with oxygen once release was complete, and regeneration could be performed as long as the hydrogel was intact.	Oxygen	50-56	microtubule actin crosslinking factor 1	Homo sapiens	0-4
23128156-10	2013	Finally, MACF gradient hydrogels were created, demonstrating that these materials can control oxygen levels on a spatial scale of millimeters and greatly enhance cellular proliferative and metabolic responses.	Oxygen	94-100	microtubule actin crosslinking factor 1	Homo sapiens	9-13
23335799-8	2013	Similarly, the geranylgeranyl transferase inhibitor GGTI-2133 (10 muM) also increased deformability and impaired low O2 tension-induced ATP release in healthy human erythrocytes (P &lt; 0.05).	Oxygen	117-119	protein geranylgeranyltransferase type I subunit beta	Homo sapiens	52-56
23376718-8	2013	The effects of gankyrin were more prominent under 3% O2 than 1% or 20% O2 conditions.	Oxygen	53-55	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	Mus musculus	15-23
23376718-8	2013	The effects of gankyrin were more prominent under 3% O2 than 1% or 20% O2 conditions.	Oxygen	71-73	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	Mus musculus	15-23
23972394-3	2013	By using a relevant ROP model, the 50/10 oxygen-induced retinopathy (OIR) model, we previously found that broad inhibition of VEGFA bioactivity using a neutralizing antibody to rat VEGF significantly reduced IVNV area compared with control IgG but also significantly reduced body weight gain in the pups, suggesting an adverse effect.	Oxygen	41-47	vascular endothelial growth factor A	Rattus norvegicus	126-130
1180173-2	1975	We have confirmed these observations under steady state conditions and also shown that the oxygen consumption depends on acid secretion in a similar way for both histamine and gastrin stimulation.	Oxygen	91-97	gastrin	Homo sapiens	176-183
23811199-9	2013	We concluded that low levels of oxygen consumption moderately activates the p53 pathway, and leads to cellular senescence, but that high levels of oxygen consumption hyperactivates the p53 pathway, which results in cell death in SOD1-deficient MEFs.	Oxygen	32-38	transformation related protein 53, pseudogene	Mus musculus	76-79
23334860-0	2013	Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.	Oxygen	75-81	dynamin 1 like	Homo sapiens	8-33
23334860-0	2013	Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.	Oxygen	75-81	dynamin 1 like	Homo sapiens	35-39
23334860-9	2013	O2 rapidly (&lt;5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Oxygen	0-2	dynamin 1 like	Homo sapiens	114-139
23334860-9	2013	O2 rapidly (&lt;5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Oxygen	0-2	dynamin 1 like	Homo sapiens	141-145
23100171-10	2013	Similarly, the expressions of ATP-binding cassette protein A3 gene, a differentiation marker of AT II cells and of peroxiredoxin 6, thioredoxin and thioredoxin reductase, three genes involved in oxygen radical protection were increased.	Oxygen	195-201	thioredoxin	Homo sapiens	132-143
23100171-10	2013	Similarly, the expressions of ATP-binding cassette protein A3 gene, a differentiation marker of AT II cells and of peroxiredoxin 6, thioredoxin and thioredoxin reductase, three genes involved in oxygen radical protection were increased.	Oxygen	195-201	thioredoxin	Homo sapiens	148-159
23297402-0	2013	Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7.	Oxygen	26-32	myoglobin	Homo sapiens	43-52
23871826-7	2013	Also, oxygen stress induced S-phase arrest of cancer cells by way of regulating expression of DNA Topo I, p53, CDK2 and Cyclin A and caused DNA damage.	Oxygen	6-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	106-109
23798557-2	2013	Hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) serves as a crucial oxygen sensor and may therefore play an important role during reepithelialization.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-51
23798557-2	2013	Hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) serves as a crucial oxygen sensor and may therefore play an important role during reepithelialization.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 1	Mus musculus	53-57
23798557-7	2013	Thus, loss of the central oxygen sensor PHD2 in keratinocytes stimulates wound closure by prompting skin epithelial cells to migrate and proliferate.	Oxygen	26-32	egl-9 family hypoxia-inducible factor 1	Mus musculus	40-44
1180173-3	1975	Furthermore the degree of oxygen extraction from the gastric circulation is significantly less (p less than 0.001) during histamine stimulation than during gastrin stimulation.	Oxygen	26-32	gastrin	Homo sapiens	156-163
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Oxygen	130-136	endothelial PAS domain protein 1	Mus musculus	86-95
5580805-0	1971	Maximal oxygen uptake at sea level and at 3,090-m altitude in high school champion runners.	Oxygen	8-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
23987100-2	2013	METHODS: We developed a transgenic mouse line in which expression of an oxygen-stable HIF-1alpha construct was controlled by a tetracycline-responsive promoter.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	86-96
23242184-11	2013	This effect is mediated by suppression of EPO 3"-enhancer activity via ATF4 without any direct effect on HIF, indicating that UPR contributes to oxygen-sensing regulation of EPO.	Oxygen	145-151	erythropoietin	Rattus norvegicus	42-45
23242184-11	2013	This effect is mediated by suppression of EPO 3"-enhancer activity via ATF4 without any direct effect on HIF, indicating that UPR contributes to oxygen-sensing regulation of EPO.	Oxygen	145-151	erythropoietin	Rattus norvegicus	174-177
5480859-4	1970	The mean slope of the increase in cerebral blood flow with decreasing arterial O(2) tension rose more quickly (P &lt; 0.05) when eucapnia was maintained when compared with the slope derived under similar hypoxic conditions without maintenance of eucapnia.	Oxygen	79-83	complement C2	Homo sapiens	111-113
23388148-1	2013	BACKGROUND: High salinity and temperature combined with presence of heavy metals and low oxygen renders deep-sea anoxic brines of the Red Sea as one of the most extreme environments on Earth.	Oxygen	89-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
23388148-1	2013	BACKGROUND: High salinity and temperature combined with presence of heavy metals and low oxygen renders deep-sea anoxic brines of the Red Sea as one of the most extreme environments on Earth.	Oxygen	89-95	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	138-141
23949217-6	2013	Immunofluorescence staining revealed that CHL1 was expressed in the carotid body (CB), the key oxygen sensor in rodents, and CHL1 expression level in the CB as assayed by western blot was decreased after hypoxic exposure.	Oxygen	95-101	cell adhesion molecule L1-like	Mus musculus	42-46
23436141-3	2013	Here we focus on the environmental factors, which are known to trigger TLR4, e.g., ozone, atmosphere particulate matter, long-lived reactive oxygen intermediate, pentachlorophenol, ionizing radiation, and toluene.	Oxygen	141-147	toll like receptor 4	Homo sapiens	71-75
22987771-5	2013	IGF-1 appeared to act through mitochondrial membrane potential stabilization and maintenance of intracellular ROS levels in very low levels of oxygen.	Oxygen	143-149	insulin like growth factor 1	Equus caballus	0-5
5518672-0	1970	Postoperative changes of ornithine carbamoyl transferase activity in serum (S-OCT) related to oxygen saturation in hepatic vein blood during operations in man.	Oxygen	94-100	plexin A2	Homo sapiens	78-81
23750001-1	2013	Hypoxia-inducible factor (HIF) 1 and HIF-2 are heterodimeric proteins composed of an oxygen-regulated HIF-1alpha or HIF-2alpha subunit, respectively, and a constitutively expressed HIF-1beta subunit, which mediate adaptive transcriptional responses to hypoxia.	Oxygen	85-91	endothelial PAS domain protein 1	Homo sapiens	116-126
23036115-9	2013	Whole root respiratory assays showed no difference between WT and sdhaf2, but micro-respirometry of the tips of roots clearly showed low oxygen consumption in sdhaf2 which could explain a metabolic deficit responsible for root tip growth.	Oxygen	137-143	succinate dehydrogenase assembly factor	Arabidopsis thaliana	159-165
4232072-0	1968	[On the effect of oxygen on the UV inactivation of myosin].	Oxygen	18-24	myosin heavy chain 14	Homo sapiens	51-57
23299479-2	2013	Previous studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membrane-anchored metalloproteinase that regulates epidermal growth factor receptor (EGFR) signaling, reduces pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	266-272	epidermal growth factor receptor	Mus musculus	181-185
23728938-2	2013	Western blot analysis revealed that along with an upregulation of hypoxia-inducible factor-1alpha, there was a time-dependent induction of periostin in MKN-45 cells under hypoxia (2% O2 ), increasing by eightfold as compared to normoxic cells.	Oxygen	183-185	periostin	Homo sapiens	139-148
6058997-12	1967	Serial tests at increasing loads yielded a straight-line relation between O(2) intake and work rate over a wide range of work rates at sea level and at altitude.	Oxygen	74-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	135-138
23340651-9	2013	We also demonstrated that 3% O(2) affected BMSC differentiation in p53 and reactive oxygen species (ROS) independent pathways.	Oxygen	29-33	transformation related protein 53, pseudogene	Mus musculus	67-70
5987178-0	1966	[Heart rate volume and oxygen levels (p02 and saturation) in liver venous blood during halothane anesthesia].	Oxygen	23-29	tumor protein, translationally-controlled 1	Homo sapiens	38-41
23287475-10	2013	This reprogramming appears to be accomplished stepwise, with the assembly of the triad into a sophisticated transcriptional, oxygen-dependent circuitry, in which Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation.	Oxygen	125-131	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	203-208
23252463-9	2013	CONCLUSIONS: Our results suggest that constitutive expression of HIF-1alpha in hepatocytes acts as a determinant of hepatic lobular structure and oxygen consumption by changing mitochondrial contents.	Oxygen	146-152	hypoxia inducible factor 1, alpha subunit	Mus musculus	65-75
23583299-9	2013	After an acute ROFA exposure, increased tissue O2 consumption may account for an augmented Nox activity, causing an increased O2(-) production.	Oxygen	47-49	NADPH oxidase	Drosophila melanogaster	91-94
23583299-9	2013	After an acute ROFA exposure, increased tissue O2 consumption may account for an augmented Nox activity, causing an increased O2(-) production.	Oxygen	126-128	NADPH oxidase	Drosophila melanogaster	91-94
23602401-4	2013	The results suggest that linking from the phenolic oxygen of selected adenosine A2A receptor antagonists is relatively well tolerated due to the extension towards extracellular space, and leads to the potential of attaching further functionality from this position.	Oxygen	51-57	adenosine A2a receptor	Homo sapiens	70-92
23476337-2	2013	The latter is situated about an inversion centre and belongs to the class of hexa-meric monoorganooxo-tin carboxyl-ates with a hexa-gonal prismatic or "drum-like" motif of the central tin-oxygen core.	Oxygen	188-194	hexosaminidase subunit alpha	Homo sapiens	77-81
23476337-2	2013	The latter is situated about an inversion centre and belongs to the class of hexa-meric monoorganooxo-tin carboxyl-ates with a hexa-gonal prismatic or "drum-like" motif of the central tin-oxygen core.	Oxygen	188-194	hexosaminidase subunit alpha	Homo sapiens	127-131
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	Oxygen	78-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
5854087-0	1965	[Kinetics of the inclusion of O-18 from heavy oxygen water into the molecule of violaxanthine].	Oxygen	46-52	immunoglobulin kappa variable 1-33	Homo sapiens	30-34
24455718-4	2013	Here, we demonstrated via antibody blocking experiments that alphaV beta5 and alpha 6 significantly promoted hESC attachment in 2% O2 only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone.	Oxygen	131-133	adaptor related protein complex 5 subunit beta 1	Homo sapiens	68-73
17806494-0	1958	Sensitivity to Oxygen During Postembryonic Development of the Wasp Habrobracon.	Oxygen	15-21	WASP actin nucleation promoting factor	Homo sapiens	62-66
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	76-78	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	adaptor related protein complex 5 subunit beta 1	Homo sapiens	50-55
24455718-6	2013	Adhered hESCs following blockage of alphaV beta5 in 2% O2 displayed a reduction in nuclear colocalisation of Oct-4 and Nanog with little effect observed in 21% O2.	Oxygen	55-57	adaptor related protein complex 5 subunit beta 1	Homo sapiens	43-48
21000737-0	1946	An experimental analysis in man of the oxygen pressure gradient from alveolar air to arterial blood during rest and exercise at sea level and at altitude.	Oxygen	39-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
24455718-6	2013	Adhered hESCs following blockage of alphaV beta5 in 2% O2 displayed a reduction in nuclear colocalisation of Oct-4 and Nanog with little effect observed in 21% O2.	Oxygen	55-57	POU class 5 homeobox 1	Homo sapiens	109-114
24455718-7	2013	Blockage of CD44 had the converse effect with dramatic reductions in nuclear colocalisation of Oct-4 and Nanog in 21% O2 cultured hESC which retained adherence, but not in 2% O2 cultured cells.	Oxygen	118-120	POU class 5 homeobox 1	Homo sapiens	95-100
33713833-9	2021	Also, our in vitro experiment supports that blocking the de novo sphingolipid synthesis pathway by myriocin, SPT1 inhibitor increased the thermogenic capacity and oxygen consumption rate in mature adipocytes.	Oxygen	163-169	mucin-like 2	Mus musculus	109-113
23685731-9	2013	CONCLUSIONS: The effects of E2 on BMP signaling in HPAEC altered depending on O2 concentration and different mechanisms may be involved.	Oxygen	78-80	bone morphogenetic protein 1	Homo sapiens	34-37
32719988-0	2021	Blockage of miR-485-5p on Cortical Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation/Reoxygenation Through Inactivating MAPK Pathway.	Oxygen	65-71	microRNA 485	Rattus norvegicus	12-19
23445753-0	2013	Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain.	Oxygen	0-6	acetylcholinesterase	Rattus norvegicus	30-50
23445753-8	2013	Our results suggest that a single treatment with AChE inhibitors at the beginning of hyperoxia attenuated the detrimental effects of oxygen toxicity in the developing brain and may pave the way for AChE inhibitors, which are currently used for the treatment of Alzheimer"s disease, as potential candidates for adjunctive neuroprotective therapies to the immature brain.	Oxygen	133-139	acetylcholinesterase	Rattus norvegicus	49-53
23232974-0	2013	Effects of oxygen tension and IGF-I on HIF-1alpha protein expression in mouse blastocysts.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	39-49
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	48-54	X-box binding protein 1	Homo sapiens	122-126
23232974-7	2013	HIF-1alpha protein was localized to the cytoplasm of blastocysts, and its levels were independent of oxygen concentration or IGF-I treatment.	Oxygen	101-107	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-10
23456860-1	2013	The hematopoietic growth factor erythropoietin (Epo) circulates in plasma and controls the oxygen carrying capacity of the blood (Fisher.	Oxygen	91-97	erythropoietin	Mus musculus	48-51
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	61-63	X-box binding protein 1	Homo sapiens	122-126
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	Oxygen	87-93	sirtuin 1	Mus musculus	177-182
23555235-7	2013	A critical physical mechanism underlying drug-resistant phenotypes may be that the Emu-myc p53-/- cells seem to pack more closely within the tumor than the Emu-myc Arf-/- cells, thus possibly exacerbating diffusion gradients of oxygen, leading to cell quiescence and hence resistance to cell-cycle specific drugs.	Oxygen	228-234	transformation related protein 53, pseudogene	Mus musculus	91-94
23103253-6	2012	Our findings identify a link between the oxygen-sensing HIF2alpha pathway and mTORC1 regulation, revealing the molecular basis of the tumor-promoting properties of HIF2alpha in von Hippel-Lindau-deficient cells.	Oxygen	41-47	endothelial PAS domain protein 1	Homo sapiens	56-65
23103253-6	2012	Our findings identify a link between the oxygen-sensing HIF2alpha pathway and mTORC1 regulation, revealing the molecular basis of the tumor-promoting properties of HIF2alpha in von Hippel-Lindau-deficient cells.	Oxygen	41-47	endothelial PAS domain protein 1	Homo sapiens	164-173
23103253-7	2012	We also describe relevant physiological scenarios, including those that occur in liver and lung tissue, wherein HIF2alpha or low-oxygen tension drive mTORC1 activity and SLC7A5 expression.	Oxygen	129-135	solute carrier family 7 member 5	Homo sapiens	170-176
33988746-6	2021	However, the increase in mitochondrial protease LON content after hypoxia exposure suggests the possibility of adaptations to optimise respiratory chain function under conditions of reduced O2 availability.	Oxygen	190-192	lon peptidase 1, mitochondrial	Homo sapiens	48-51
23194259-1	2012	We describe a route to the development of novel PtNiN core-shell catalysts with low Pt content shell and inexpensive NiN core having high activity and stability for the oxygen reduction reaction (ORR).	Oxygen	169-175	ninein	Homo sapiens	50-53
33986256-0	2021	Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2.	Oxygen	11-17	endothelial PAS domain protein 1	Homo sapiens	115-124
22578139-10	2012	Transcutaneous oxygen readings were lower in the Val/Leu or Leu/Leu group [Val/Leu or Leu/Leu 16 (0-58) mmHg vs. Val/Val 35 (1-65) mmHg; P = 0.008].	Oxygen	15-21	membrane spanning 4-domains A1	Homo sapiens	90-96
34010766-2	2021	To occupy a presumed hydrophobic space between the pyrimidine and piperidine rings in interaction with GPR119, we replaced the linker oxygen with nitrogen.	Oxygen	134-140	G protein-coupled receptor 119	Homo sapiens	103-109
22697171-0	2012	Diversity, distribution, and expression of diazotroph  nifH  genes in oxygen-deficient waters of the Arabian Sea.	Oxygen	70-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
22697171-3	2012	Model prediction and physiological inhibition of N(2) fixation by oxygen, however, suggest that N(2) fixation should be enhanced near the oxygen-deficient zone (ODZ) of the Arabian Sea.	Oxygen	138-144	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
33964948-5	2021	In vitro studies showed that the 3D short fiber sponge provided an oxygen-rich environment for cell growth, which was conducive to the 3D proliferation and growth of HUVECs, stimulated the expression of VEGF, and well promoted the vascularization of HUVECs.	Oxygen	67-73	vascular endothelial growth factor A	Rattus norvegicus	203-207
22535284-7	2012	Additionally, a higher oxygen tension led to an upregulation of the expression of IL-6, MCP-1, and PPAR-gamma, while ANGPTL4 was downregulated in the hyperoxia group with respect to control.	Oxygen	23-29	C-C motif chemokine ligand 2	Homo sapiens	88-93
33974878-4	2021	Since the original report by Bach and Mitchell (1996) concerning long-term facilitation of phrenic motor output elicited by brief, episodic exposure to reduced oxygen, a series of studies in animal models have led to the realization that acute intermittent hypoxia may have tremendous potential for inducing neuroplasticity and functional recovery in the injured spinal cord.	Oxygen	160-166	acyl-CoA thioesterase 7	Homo sapiens	29-33
23037900-0	2012	Adipose tissue oxygen tension:  implications for chronic metabolic and inflammatory diseases.	Oxygen	15-21	WD and tetratricopeptide repeats 1	Mus musculus	0-7
23037900-2	2012	RECENT FINDINGS: The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose tissue PO2.	Oxygen	52-58	WD and tetratricopeptide repeats 1	Mus musculus	37-44
33730876-9	2021	Thus, as compared with wild-type counterparts, mice lacking the lectin-like domain of TM exhibit reduced neovascularization of granulation tissues during cutaneous wound healing and less retinal neovascularization in a model of oxygen-induced retinopathy.	Oxygen	228-234	thrombomodulin	Mus musculus	86-88
23037900-2	2012	RECENT FINDINGS: The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose tissue PO2.	Oxygen	52-58	WD and tetratricopeptide repeats 1	Mus musculus	108-115
23037900-8	2012	Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype.	Oxygen	25-27	WD and tetratricopeptide repeats 1	Mus musculus	9-16
23037900-8	2012	Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype.	Oxygen	25-27	WD and tetratricopeptide repeats 1	Mus musculus	98-105
23037900-8	2012	Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype.	Oxygen	25-27	WD and tetratricopeptide repeats 1	Mus musculus	98-105
23037900-8	2012	Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype.	Oxygen	25-27	WD and tetratricopeptide repeats 1	Mus musculus	98-105
33951695-8	2021	TRPM7 overexpression also abolished miR-129-5p-induced elevation on cell viability and reduction on apoptosis as well as attenuated miR-129-5p-induced inhibition on reactive oxygen species and IL-1beta production.	Oxygen	174-180	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	0-5
22714395-12	2012	We propose that HBB, along with other genes involved in oxygen metabolism, confers a more aggressive metastatic phenotype in BrCa cells disseminated to bone.	Oxygen	56-62	hemoglobin subunit beta	Homo sapiens	16-19
23178531-9	2012	Several cell lines were found to have an increased IRP1 basal activity at 20% O2 compared to 5% O2, which may lower HIF2alpha expression in some of the cell lines in a VHL-independent manner.	Oxygen	78-80	endothelial PAS domain protein 1	Homo sapiens	116-125
23178531-9	2012	Several cell lines were found to have an increased IRP1 basal activity at 20% O2 compared to 5% O2, which may lower HIF2alpha expression in some of the cell lines in a VHL-independent manner.	Oxygen	96-98	endothelial PAS domain protein 1	Homo sapiens	116-125
22956520-6	2012	High O(2)-cultured oocytes also showed higher amounts of SOD1, SOD2, GSR, GPX1, and CAT mRNA.	Oxygen	5-9	glutathione peroxidase 1	Canis lupus familiaris	74-78
33951696-0	2021	Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.	Oxygen	47-53	calmodulin 2	Homo sapiens	126-131
33857860-12	2021	Here we propose that SmO2 steady-state representing CP as critical oxygenation or CO. And the tissue oxygen reserve above CO would then be identified as O".	Oxygen	67-73	ceruloplasmin	Homo sapiens	52-54
23098648-0	2012	Role of the Skp1 prolyl-hydroxylation/glycosylation pathway in oxygen dependent submerged development of Dictyostelium.	Oxygen	63-69	S-phase kinase associated protein 1	Homo sapiens	12-16
23098648-3	2012	In Dictyostelium, genetic studies show that hydroxylation of Skp1 by PhyA, and subsequent glycosylation of the hydroxyproline, is required for normal oxygen sensing during multicellular development at an air/water interface.	Oxygen	150-156	S-phase kinase associated protein 1	Homo sapiens	61-65
23098648-8	2012	CONCLUSION: We propose that, in the physiological range, oxygen or downstream metabolic effectors control the timing of developmental progression via activation of newly synthesized Skp1.	Oxygen	57-63	S-phase kinase associated protein 1	Homo sapiens	182-186
33996536-6	2021	Results: We show that MB protein is expressed in a wide variety of cancers, benign tumors, cancer-adjacent normal tissues, hyperplastic tissue samples and normal brain tissue, and low oxygen tensions modulate MB protein expression in different brain cancers, including GBM.	Oxygen	184-190	myoglobin	Homo sapiens	209-211
23100432-6	2012	We report that microglial IRAK4 is necessary in vitro for fAbeta to activate the canonical pro-inflammatory signaling pathways leading to activation of p38, JNK, and ERK MAP kinases and to generate reactive oxygen species.	Oxygen	207-213	fumarylacetoacetate hydrolase	Mus musculus	58-64
22923613-1	2012	Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin.	Oxygen	11-17	heme oxygenase 1	Homo sapiens	31-44
23506274-5	2013	Under 20% oxygen, but not 1.5% or 5%, NGF decreased apoptosis in mouse ovaries by down-regulating the pro-apoptotic genes Bax and p53.	Oxygen	10-16	transformation related protein 53, pseudogene	Mus musculus	130-133
23143703-9	2013	These results suggest that both oxygen-dependent and -independent fuel substrate pathways are important determinants of BMX performance.	Oxygen	32-38	BMX non-receptor tyrosine kinase	Homo sapiens	120-123
23584901-3	2013	Expression of KLK1 and the KV7 channel subunits, KCNQ1, KCNE1, KCNE3, and KCNE5, increased during differentiation of cultured human trophoblast cells in a 20% O2 environment.	Oxygen	159-161	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	49-54
23584901-4	2013	Notably, together with ERRgamma, expression of KLK1, KCNQ1, KCNE1, KCNE3, and KCNE5 was markedly reduced when cells were cultured in a hypoxic environment (2% O2).	Oxygen	159-161	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	53-58
23524851-2	2013	Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the unfolded protein response (UPR) kinase PERK and the lysosomal enzyme cathepsin B.	Oxygen	82-88	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	215-219
23630130-3	2013	We examined whether deletion of PHD2, the main oxygen sensor, in adipocytes affects diet-induced obesity and associated metabolic abnormalities.	Oxygen	47-53	egl-9 family hypoxia-inducible factor 1	Mus musculus	32-36
23412555-1	2013	Iron L-edge X-ray absorption spectra of the active centre of myoglobin in the met-form, in the reduced form and upon ligation to O2, CO, NO and CN are presented.	Oxygen	129-131	myoglobin	Homo sapiens	61-70
23530942-7	2013	By sharply opening the OFA damper to deepen the air-staging conditions, although NOx emissions could finally reduce to 503 mg/m(3) at 6% O2 (i.e., an ultralow NOx level for down-fired furnaces), carbon in fly ash jumped sharply to 15.10%.	Oxygen	137-139	NADPH oxidase	Drosophila melanogaster	81-84
23530942-7	2013	By sharply opening the OFA damper to deepen the air-staging conditions, although NOx emissions could finally reduce to 503 mg/m(3) at 6% O2 (i.e., an ultralow NOx level for down-fired furnaces), carbon in fly ash jumped sharply to 15.10%.	Oxygen	137-139	NADPH oxidase	Drosophila melanogaster	159-162
23671606-4	2013	Moreover, hESCs cultured at atmospheric O2 levels expressed significantly less OCT4, SOX2 and NANOG than those maintained at 5% O2.	Oxygen	40-42	POU class 5 homeobox 1	Homo sapiens	79-83
23671606-8	2013	GLUT1 expression correlated with glucose consumption and using siRNA and chromatin immunoprecipitation was found to be directly regulated by hypoxia inducible factor (HIF)-2alpha at 5% O2.	Oxygen	185-187	endothelial PAS domain protein 1	Homo sapiens	141-178
23644619-7	2013	RAGE expression, TNF-alpha, and IL-6 were downregulated by controlled oxygen treatment (p &lt; 0.001).	Oxygen	70-76	tumor necrosis factor	Canis lupus familiaris	17-26
23656416-6	2013	Furthermore, this oxygen effect was curtailed by the ET-1/ETA receptor antagonist BQ-123.	Oxygen	18-24	endothelin 1	Mus musculus	53-57
23080524-10	2013	In the cyanotic group, baseline HSP 27 expression also significantly correlated with oxygen extraction ratio (p = 0.028), post-operative basal septal velocity (p = 0.036) and mixed venous oxygen saturation (p = 0.02), markers of improved cardiac output/contraction.	Oxygen	85-91	heat shock protein family B (small) member 1	Homo sapiens	32-38
23080524-10	2013	In the cyanotic group, baseline HSP 27 expression also significantly correlated with oxygen extraction ratio (p = 0.028), post-operative basal septal velocity (p = 0.036) and mixed venous oxygen saturation (p = 0.02), markers of improved cardiac output/contraction.	Oxygen	188-194	heat shock protein family B (small) member 1	Homo sapiens	32-38
23475705-4	2013	First, as previously well characterized, we observe sterol import under low oxygen levels in S. cerevisiae and C. glabrata, which is dependent on the transcription factor Upc2 and/or its orthologs or paralogs.	Oxygen	76-82	Upc2p	Saccharomyces cerevisiae S288C	171-175
23398717-7	2013	Our results suggest that optimized expression levels of GRE3, XYL2, and XYL3 could overcome redox imbalance during xylose fermentation by engineered S. cerevisiae under oxygen-limited conditions.	Oxygen	169-175	D-xylulose reductase XYL2	Saccharomyces cerevisiae S288C	62-66
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Oxygen	68-74	endothelial PAS domain protein 1	Homo sapiens	221-230
23509317-10	2013	The HIF2A mutations in these patients were clustered adjacent to an oxygen-sensing proline residue, affecting HIF2alpha interaction with the prolyl hydroxylase domain 2-containing protein, decreasing the hydroxylation of HIF2alpha, and reducing HIF2alpha affinity for the von Hippel-Lindau protein and its degradation.	Oxygen	68-74	endothelial PAS domain protein 1	Homo sapiens	221-230
23475074-4	2013	In particular, we focus on the oxygen-sensing role of ubiquinol-cytochrome c reductase binding protein (UQCRB) of mitochondrial Complex III through identification of the protein target and the mode of action of a natural small molecule, terpestacin.	Oxygen	31-37	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	54-102
23385964-0	2013	Response of vascular endothelial growth factor and angiogenesis-related genes to stepwise increases in inspired oxygen in neonatal rat lungs.	Oxygen	112-118	vascular endothelial growth factor A	Rattus norvegicus	12-46
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	60-66	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-42
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	60-66	hypoxia inducible factor 1, alpha subunit	Mus musculus	44-54
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	68-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-42
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	68-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	44-54
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	146-148	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-42
23513056-1	2013	RATIONALE: Hypoxia-inducible factor-1alpha (HIF-1alpha), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states.	Oxygen	146-148	hypoxia inducible factor 1, alpha subunit	Mus musculus	44-54
23613849-5	2013	Moreover, the expression of two stem cell marker genes, Nanog and Oct-4, was upregulated in the cells cultured in 5% O2.	Oxygen	117-119	POU class 5 homeobox 1	Homo sapiens	66-71
23613849-6	2013	Finally, in cultures under 5% O2, more hTSCs expressed the stem cell markers nucleostemin, Oct-4, Nanog and SSEA-4.	Oxygen	30-32	POU class 5 homeobox 1	Homo sapiens	91-96
23593116-1	2013	Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various genes associated with low oxygen consumption.	Oxygen	125-131	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
23593116-1	2013	Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various genes associated with low oxygen consumption.	Oxygen	125-131	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-44
23514118-6	2013	The NH group of Gly, which as hydrogen bond donor competes with the NH group of Cys4 for the carbonyl oxygen atom of Cys1 as hydrogen bond acceptor, plays a relevant role for the structure and spectroscopic properties of the peptide.	Oxygen	102-108	cystin 1	Homo sapiens	117-121
23258228-10	2013	Intratracheal tPA diminished airway-obstructive fibrin-containing casts while improving clinical respiratory distress, pulmonary gas exchange, tissue oxygenation, and oxygen utilization in our model of severe chemically induced plastic bronchitis.	Oxygen	150-156	plasminogen activator, tissue type	Rattus norvegicus	14-17
22998595-7	2012	RESULTS: Exposure of three different breast cancer cell lines to moderate (1% O2) and severe (0.1% O2) hypoxia resulted in significant increases in the number of exosomes present in the conditioned media as determined by NTA and CD63 immunoblotting.	Oxygen	99-101	CD63 molecule	Homo sapiens	229-233
22926880-5	2012	Nutrient load reductions following the Baltic Sea Action Plan can reduce the deterioration of oxygen conditions.	Oxygen	94-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
33929634-5	2021	Our results found that 25 ng/ml resistin could significantly increase cisplatin-induced apoptosis and G2/M phase arrest, enhance reactive oxygen species generation, exacerbate the collapse of mitochondrial membrane potential, promote the distribution of cytochrome C in the cytoplasm from mitochondria, and activate caspase 3.	Oxygen	138-144	resistin	Homo sapiens	32-40
21745179-0	2012	Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products.	Oxygen	62-68	progestagen associated endometrial protein	Homo sapiens	30-33
22978553-6	2013	Endogenous thiol antioxidants glutathione and thioredoxin are modulated with high oxygen consumption and ROS generation during physical exercise, controlling cellular function through redox-sensitive signaling and protein-protein interactions.	Oxygen	82-88	thioredoxin	Homo sapiens	46-57
33895952-7	2021	The mechanism investigation showed that CP promoted the release of organic matter during the co-digestion, and the higher the content of CP, the greater the release of soluble chemical oxygen demand.	Oxygen	185-191	ceruloplasmin	Homo sapiens	40-42
23724749-6	2013	Travelling from sea level to an altitude of 2,500 m causes a 20% reduction in the partial pressure of inspired oxygen.	Oxygen	111-117	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	16-19
33895952-7	2021	The mechanism investigation showed that CP promoted the release of organic matter during the co-digestion, and the higher the content of CP, the greater the release of soluble chemical oxygen demand.	Oxygen	185-191	ceruloplasmin	Homo sapiens	137-139
22095574-3	2012	Here, we have studied the function of the cellular oxygen sensor, factor inhibiting HIF-1 (FIH), which controls the activity of hypoxia-inducible factor-1.	Oxygen	51-57	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	66-89
22095574-3	2012	Here, we have studied the function of the cellular oxygen sensor, factor inhibiting HIF-1 (FIH), which controls the activity of hypoxia-inducible factor-1.	Oxygen	51-57	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	91-94
33919308-6	2021	Under both oxygen conditions cells were exposed to proinflammatory cytokines involved significantly in acute inflammation, i.e., IFNgamma, TNFalpha and IL-1beta at different concentrations.	Oxygen	11-17	interleukin 1 alpha	Homo sapiens	152-160
22891315-4	2012	The (18)O-labeling experiments indicated that the oxygen incorporated into the monooxygenated products was derived almost exclusively from H(2)(18)O(2), suggesting that electron transfer was coupled to the transfer of oxygen from a ferryl intermediate of IDO.	Oxygen	50-56	indoleamine 2,3-dioxygenase 1	Homo sapiens	255-258
23361906-0	2013	Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas.	Oxygen	30-36	endothelial PAS domain protein 1	Homo sapiens	6-11
33912037-6	2021	3"-SL significantly reversed the IL-1beta mediated expression levels of reactive oxygen species in IL-1beta-stimulated chondrocytic cells.	Oxygen	81-87	interleukin 1 alpha	Homo sapiens	33-41
23556733-9	2013	Cartesian coordinates for oxygen and hydrogen atoms in the sI, sII, and sH unit cells are reported for reference.	Oxygen	26-32	transcription elongation factor A1	Homo sapiens	63-66
24432128-3	2013	Glucose-O-omega-saturated fatty acids of various chain lengths were synthesized and tested for their potential to activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, and the results were compared with equivalent non-modified fatty acid controls.	Oxygen	168-174	uncoupling protein 1	Homo sapiens	137-157
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Oxygen	135-141	uncoupling protein 1	Homo sapiens	104-124
23418351-6	2013	In the present study we show that haploinsufficiency of endoglin results in attenuation of retinal neovascularization during oxygen-induced ischemic retinopathy.	Oxygen	125-131	endoglin	Mus musculus	56-64
22891315-4	2012	The (18)O-labeling experiments indicated that the oxygen incorporated into the monooxygenated products was derived almost exclusively from H(2)(18)O(2), suggesting that electron transfer was coupled to the transfer of oxygen from a ferryl intermediate of IDO.	Oxygen	83-89	indoleamine 2,3-dioxygenase 1	Homo sapiens	255-258
22891315-6	2012	We conclude that IDO inserts oxygen into indole in a reaction that is mechanistically analogous to the "peroxide shunt" pathway of cytochrome P450.	Oxygen	29-35	indoleamine 2,3-dioxygenase 1	Homo sapiens	17-20
22745131-9	2012	Collectively, these findings show that the down-regulation of Dicer under chronic hypoxia is an adaptive mechanism that serves to maintain the cellular hypoxic response through HIF-alpha- and microRNA-dependent mechanisms, thereby providing an essential mechanistic insight into the oxygen-dependent microRNA regulatory pathway.	Oxygen	283-289	dicer 1, ribonuclease III	Homo sapiens	62-67
22615433-5	2012	Human CBs express most of the genes previously proposed to be involved in oxygen sensing and signalling based on animal studies, including NOX2, AMPK, CSE and oxygen sensitive K+ channels.	Oxygen	74-80	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	151-154
22661511-12	2012	Ad-hAR-expressing HL-1 cardiac cells, exposed to hypoxia (0.5% O(2)) and reoxygenation (20.9% O(2)), had greater LDH release compared with control HL-1 cells (P &lt; 0.05).	Oxygen	63-67	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	3-6
33912037-6	2021	3"-SL significantly reversed the IL-1beta mediated expression levels of reactive oxygen species in IL-1beta-stimulated chondrocytic cells.	Oxygen	81-87	interleukin 1 alpha	Homo sapiens	99-107
33826895-6	2021	Mechanistically, the poised state is invoked by activation of the mitochondrial electron transport chain that leads to amplified production of reactive oxygen species in addition to omnipresent guanosine triphosphate (GTP) with consequential upregulation of pro-differentiation beta-catenin.	Oxygen	152-158	catenin beta 1	Homo sapiens	278-290
22652601-5	2012	In a model of oxygen-induced retinopathy, endothelial-specific RTEF-1 overexpressing mice had enhanced angiogenic sprouting and vascular structure remodeling, resulting in the formation of a denser and more highly interconnected superficial capillary plexus.	Oxygen	14-20	TEA domain family member 4	Mus musculus	63-69
23136924-2	2013	In the presence of light and oxygen, methylene blue promotes irreversible inhibition of human BChE as a function of time, requiring 3 h irradiation to inhibit 95% activity.	Oxygen	29-35	butyrylcholinesterase	Homo sapiens	94-98
23348708-7	2013	Taken together, these results suggest that the ERK-mediated Ser phosphorylation of p47(phox) is not implicated in the assembly of NADPH oxidase or O2( -) generation, and that O2( -) generation is partly attributable to p38 MAPK signaling through mechanisms other than p47(phox) activation, Akt activation and S100A9 membrane recruitment in fMLP-stimulated neutrophils.	Oxygen	175-177	pleckstrin	Homo sapiens	83-86
33745276-3	2021	The alkoxo oxygens of the two eta1:eta2:eta1-(py)2C(CH2NO2)(O)- ligands doubly bridge the InIII centers and create a {In2(mu2-OR)2}4+ core.	Oxygen	11-18	secreted phosphoprotein 1	Homo sapiens	30-34
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Oxygen	46-52	endothelial PAS domain protein 1	Mus musculus	9-19
22249620-10	2012	Our findings indicate an oxygen- and nutrition-dependent anti-migratory, but pro-proliferative role of CPE in gliomas with prognostic impact for patient survival, thereby contributing to the understanding of the "go or grow" hypothesis in gliomas.	Oxygen	25-31	carboxypeptidase E	Homo sapiens	103-106
33745276-3	2021	The alkoxo oxygens of the two eta1:eta2:eta1-(py)2C(CH2NO2)(O)- ligands doubly bridge the InIII centers and create a {In2(mu2-OR)2}4+ core.	Oxygen	11-18	secreted phosphoprotein 1	Homo sapiens	40-44
22734574-3	2012	In ob/ob mice, which lack leptin, metabolic heat production (oxygen consumption, Vo(2)) was suppressed in 20 C cold in both the light and dark phases, resulting in hypothermia.	Oxygen	61-67	leptin	Mus musculus	26-32
23292195-6	2013	In vitro studies indicated that the up-regulation of HSPA12B may be involved in oxygen-glucose deprivation-induced PC12 cell death.	Oxygen	80-86	heat shock protein family A (Hsp70) member 12B	Rattus norvegicus	53-60
33474683-2	2021	Particularly, the HIF-1alpha protein is sensitive to oxygen and plays a critical role in hypoxia regulation.	Oxygen	53-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-28
23243286-3	2013	To investigate the effects of hypoxia on HSCs, we blocked O2-dependent HIF-1alpha degradation in vivo in mice by injecting 2 structurally unrelated prolyl hydroxylase domain (PHD) enzyme inhibitors: dimethyloxalyl glycine and FG-4497.	Oxygen	58-60	hypoxia inducible factor 1, alpha subunit	Mus musculus	71-81
23156718-0	2012	[The variation of PPAR pathway molecules in the lung tissue of rats under hyperbaric oxygen exposure].	Oxygen	85-91	peroxisome proliferator activated receptor alpha	Rattus norvegicus	18-22
33635334-2	2021	beta-globin associates with alpha-globin to form adult hemoglobin (HbA, alpha2beta2), the main oxygen-carrier in erythrocytes.	Oxygen	95-101	hemoglobin subunit beta	Homo sapiens	0-11
23156718-1	2012	OBJECTIVE: To study the expression pattern of peroxisome proliferator-activated receptor (PPAR) pathway molecules in rat lung tissue under hyperbaric oxygen exposure.	Oxygen	150-156	peroxisome proliferator activated receptor alpha	Rattus norvegicus	46-88
23156718-1	2012	OBJECTIVE: To study the expression pattern of peroxisome proliferator-activated receptor (PPAR) pathway molecules in rat lung tissue under hyperbaric oxygen exposure.	Oxygen	150-156	peroxisome proliferator activated receptor alpha	Rattus norvegicus	90-94
23156718-7	2012	RT-PCR results suggested that PPAR-8 and PPAR-Y were up-regulated in the lung tissue after a long time exposure to hyperbaric oxygen.	Oxygen	126-132	peroxisome proliferator activated receptor alpha	Rattus norvegicus	30-34
23156718-7	2012	RT-PCR results suggested that PPAR-8 and PPAR-Y were up-regulated in the lung tissue after a long time exposure to hyperbaric oxygen.	Oxygen	126-132	peroxisome proliferator activated receptor alpha	Rattus norvegicus	41-45
23351342-6	2013	RESULTS: Cloning based on CLB expression had a differential effect on mitochondrial morphology, movement and oxygen utilization in each of three sub-cloned lines, but no long-term change in CLB expression.	Oxygen	109-115	citramalyl-CoA lyase	Homo sapiens	26-29
33750458-0	2021	LncRNA MALAT1 aggravates oxygen-glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis.	Oxygen	25-31	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	7-13
23287791-3	2013	METHODS: ROP was induced in wild-type (WT) and GPx1 knockout (KO) mice by exposing neonatal mice to 75% oxygen from postnatal days 7 to 11, followed by 1 week of room air.	Oxygen	104-110	glutathione peroxidase 1	Mus musculus	47-51
23078527-2	2013	The purpose of the current study was to determine whether TACR1 single nucleotide polymorphisms (SNPs) were associated with (i) blood oxygen level dependent (BOLD) activation in response to gustatory alcohol cues in a sample of heavy drinkers and (ii) Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) AD symptom count in a large, publicly available data set-the Study of Addictions: Genetics and Environment Genome Wide Association study (SAGE GWAS) (Bierut et al., 2010).	Oxygen	134-140	tachykinin receptor 1	Homo sapiens	58-63
23712868-7	2013	Expression of the HIF-1alpha oxygen-dependent degradation domain mutant in cells resulted in elevated AGR2 levels and an increased ability to induce HUVEC migration and tube formation in vitro and enhanced growth and vascularity of tumor xenografts in vivo, which were prevented by AGR2 knockdown.	Oxygen	29-35	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	102-106
23156718-8	2012	CONCLUSION: Pro-longed hyperbaric oxygen exposure causing pulmonary oxygen toxicity can induce the activation of the PPAR pathway.	Oxygen	34-40	peroxisome proliferator activated receptor alpha	Rattus norvegicus	117-121
23156718-8	2012	CONCLUSION: Pro-longed hyperbaric oxygen exposure causing pulmonary oxygen toxicity can induce the activation of the PPAR pathway.	Oxygen	68-74	peroxisome proliferator activated receptor alpha	Rattus norvegicus	117-121
22748015-1	2012	BACKGROUND: Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max).	Oxygen	88-94	erythropoietin	Mus musculus	12-26
22748015-1	2012	BACKGROUND: Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max).	Oxygen	88-94	erythropoietin	Mus musculus	28-31
22748015-1	2012	BACKGROUND: Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max).	Oxygen	146-152	erythropoietin	Mus musculus	12-26
22748015-1	2012	BACKGROUND: Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max).	Oxygen	146-152	erythropoietin	Mus musculus	28-31
33750458-0	2021	LncRNA MALAT1 aggravates oxygen-glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis.	Oxygen	25-31	high mobility group AT-hook 1	Homo sapiens	146-151
24193262-1	2013	BACKGROUND AND AIMS: Transketolase-like (TKTL) 1 is one of the key enzymes for anaerobic sugar degradation even in the presence of oxygen (aerobic glycolysis).	Oxygen	131-137	transketolase like 1	Homo sapiens	21-48
24193262-6	2013	Regulation of TKTL1 under oxygen depletion was analyzed by cultivating cells either in a three-dimensional spheroid model or in a hypoxia incubator chamber.	Oxygen	26-32	transketolase like 1	Homo sapiens	14-19
33750458-2	2021	RESULTS: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the expression of MALAT1 was significantly increased during OGD/R.	Oxygen	18-24	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	116-122
33507881-7	2021	Mechanistically, KLF11 not only inhibited the EC inflammatory response but also diminished MMP9 expression and activity and reduced NADPH oxidase 2-mediated production of reactive oxygen species in ECs.	Oxygen	180-186	Kruppel-like factor 11	Mus musculus	17-22
23450447-4	2013	Available evidence indicates that reduced GH signalling is linked to extended longevity by multiple interacting mechanisms including increased stress resistance, reduced growth, altered profiles of cytokines produced by the adipose tissue, and various metabolic adjustments such as enhanced insulin sensitivity, increased oxygen consumption (VO2/g) and reduced respiratory quotient.	Oxygen	322-328	growth hormone	Mus musculus	42-44
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Oxygen	58-64	ceruloplasmin	Homo sapiens	90-103
24015573-10	2013	The value deltaHsub,M--deltaHf,MOx equals the heat of formation of that metal"s oxide from a gaseous metal atom plus O2(g), so it reflects the strength of the chemical bonds which that metal atom can make to oxygen, and OmegaM2/3 simply normalizes this energy to the area per metal atom, since Eadh is the adhesion energy per unit area.	Oxygen	117-119	monooxygenase DBH like 1	Homo sapiens	31-34
24015573-10	2013	The value deltaHsub,M--deltaHf,MOx equals the heat of formation of that metal"s oxide from a gaseous metal atom plus O2(g), so it reflects the strength of the chemical bonds which that metal atom can make to oxygen, and OmegaM2/3 simply normalizes this energy to the area per metal atom, since Eadh is the adhesion energy per unit area.	Oxygen	208-214	monooxygenase DBH like 1	Homo sapiens	31-34
33744681-2	2021	Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources.	Oxygen	212-218	ceruloplasmin	Homo sapiens	90-103
33599473-6	2021	It was demonstrated that after creating nanopores by the O2 plasma treatment, the NATMs were salt-resistant and simultaneously showed 3-5 times higher gas (CO2) permeance than the state-of-the-art commercial polymeric membranes.	Oxygen	57-59	gastrin	Homo sapiens	151-154
23821932-3	2013	The decrease in the rate of oxygen consumption in a concentration NaHS 10(-9) mol/l and 10(-8) mol/l associated with an increased conjugation of oxidation and phosphorylation, as evidenced by the increase in the respiratory control, the efficiency of oxidative phosphorylation (ADP/O) is not changed.	Oxygen	28-34	WD and tetratricopeptide repeats 1	Homo sapiens	278-281
33522808-0	2021	HMNTA Complexes of Tetravalent Metal Ions: On the Roles of Carbonyl Oxygen and Amine Nitrogen in the Stabilization of Gas-Phase M(HMNTA)24+ Complexes.	Oxygen	68-74	gastrin	Homo sapiens	118-121
33606934-3	2021	It is widely accepted that the protonation in the gas phase takes place primarily on the carbonyl oxygen atom when the sample is sprayed in methanol and on the nitrogen atom when acetonitrile is used as the spray solvent.	Oxygen	98-104	gastrin	Homo sapiens	50-53
23150513-6	2013	These factors, combined with significant anemia found in eNOS KO fetuses, would be anticipated to reduce fetal oxygen delivery and contribute to the fetal tissue hypoxia that was detected in the heart, lung, kidney, and liver by immunohistochemistry using pimonidazole.	Oxygen	111-117	nitric oxide synthase 3, endothelial cell	Mus musculus	57-61
33737880-6	2021	At sea level, the ultimate drop in oxygen partial pressure will be less than 2.5 mm Hg out of a baseline of 159 mmHg.	Oxygen	35-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	3-6
24379900-2	2013	In this study, we characterized the involvement of NADPH oxidase (Nox), a multisubunit enzyme that catalyzes the reduction of oxygen, in the 6-hydroxydopamine- (6-OHDA-) induced PD mice model and compared for the first time the effects of this neurotoxin in mice lacking gp91(phox-/-), the catalytic subunit of Nox2, and pharmacological inhibition of Nox with apocynin.	Oxygen	126-132	paired Ig-like receptor B	Mus musculus	271-275
25474903-1	2013	We have shown that the decrease in oxygen tension in the culture medium of multipotent mesenchymal stromal cells (MMSCs) results in a short-term reduction in the proportion of CD73(+)-cells in the population, without effecting the number of cells expressing other constitutive surface markers (CD90 and CD105).	Oxygen	35-41	Thy-1 cell surface antigen	Homo sapiens	294-298
23234364-1	2012	We have developed a new catalyst supported on graphitized carbon black (GCB), which exhibits higher resistance to carbon corrosion than a conventional carbon black (CB), in order to favor both high mass activity for the oxygen reduction reaction (ORR) and high durability.	Oxygen	220-226	glucosylceramidase beta	Homo sapiens	72-75
23234364-4	2012	The temperature dependence of the ORR activity of the Pt(2 ML)-PtCo((2 nm))/GCB catalyst was evaluated from the hydrodynamic voltammograms in O(2)-saturated 0.1 M HClO(4) solution at 30-90  C by the channel flow double electrode (CFDE) technique.	Oxygen	142-146	glucosylceramidase beta	Homo sapiens	76-79
33737880-8	2021	The implications for normal human health is negligible because respiratory O2 consumption in healthy individuals is only weakly dependent on ambient partial pressure, especially at sea level.	Oxygen	75-77	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	181-184
33511663-0	2021	Tip-Enhanced Electric Field: A New Mechanism Promoting Mass Transfer in Oxygen Evolution Reactions.	Oxygen	72-78	TOR signaling pathway regulator	Homo sapiens	0-3
22311647-4	2012	Both nox-2 and AhpR catalyze the same reaction in the presence of oxygen.	Oxygen	66-72	alkyl hydroperoxide reductase subunit F	Bacillus cereus ATCC 14579	15-19
22627788-1	2012	The blood O(2)-carrying capacity is maintained by the O(2)-regulated production of erythropoietin (Epo), which stimulates the proliferation and survival of red blood cell progenitors.	Oxygen	10-14	erythropoietin	Rattus norvegicus	83-97
33569547-8	2021	Treatment of the hCMEC/D3 cells with Hsp90 inhibitors counteracted those events, and reduced the generation of the hydrogen peroxide - induced reactive oxygen species.	Oxygen	152-158	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-42
22627788-1	2012	The blood O(2)-carrying capacity is maintained by the O(2)-regulated production of erythropoietin (Epo), which stimulates the proliferation and survival of red blood cell progenitors.	Oxygen	10-14	erythropoietin	Rattus norvegicus	99-102
22627788-1	2012	The blood O(2)-carrying capacity is maintained by the O(2)-regulated production of erythropoietin (Epo), which stimulates the proliferation and survival of red blood cell progenitors.	Oxygen	54-58	erythropoietin	Rattus norvegicus	83-97
22627788-1	2012	The blood O(2)-carrying capacity is maintained by the O(2)-regulated production of erythropoietin (Epo), which stimulates the proliferation and survival of red blood cell progenitors.	Oxygen	54-58	erythropoietin	Rattus norvegicus	99-102
33570246-7	2021	Alteration of the glycolytic ability of GC cells with ISL1 knockdown was validated by measuring the extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) and by detecting glucose consumption and lactate production.	Oxygen	144-150	ISL LIM homeobox 1	Homo sapiens	54-58
22961008-2	2012	HIF prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) are oxygen sensors involved in adaptive response to hypoxia.	Oxygen	58-64	egl-9 family hypoxia-inducible factor 1	Mus musculus	38-42
32335773-0	2021	Knockdown of TRIM22 Relieves Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Inflammation Through Inhibition of NF-kappaB/NLRP3 Axis.	Oxygen	29-35	tripartite motif containing 22	Homo sapiens	13-19
22961008-2	2012	HIF prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) are oxygen sensors involved in adaptive response to hypoxia.	Oxygen	58-64	egl-9 family hypoxia-inducible factor 3	Mus musculus	48-52
22452597-0	2012	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo (Bubalus bubalis) embryos affect mRNA expression of BCL-2, BCL-XL, MCL-1, BAX and BID.	Oxygen	0-6	induced myeloid leukemia cell differentiation protein Mcl-1	Bubalus bubalis	157-162
22452597-6	2012	At the 8- to 16-cell stage, where developmental block occurs in buffalo, the relative mRNA abundance of BCL-2 and MCL-1 was highest under 5% O(2) concentration and that of BAX and BID was highest (p &lt; 0.05) under 20% O(2) concentration.	Oxygen	141-145	induced myeloid leukemia cell differentiation protein Mcl-1	Bubalus bubalis	114-119
31532899-4	2021	Surface and interface engineering have shown bright prospects to construct highly efficient Mox C-based electrocatalysts for energy conversion including the hydrogen evolution reaction, oxygen evolution reaction, nitrogen reduction reaction, and carbon dioxide reduction reaction.	Oxygen	186-192	monooxygenase DBH like 1	Homo sapiens	92-95
22452597-6	2012	At the 8- to 16-cell stage, where developmental block occurs in buffalo, the relative mRNA abundance of BCL-2 and MCL-1 was highest under 5% O(2) concentration and that of BAX and BID was highest (p &lt; 0.05) under 20% O(2) concentration.	Oxygen	220-224	induced myeloid leukemia cell differentiation protein Mcl-1	Bubalus bubalis	114-119
33652804-0	2021	Oxygen-Ozone Therapy in the Rehabilitation Field: State of the Art on Mechanisms of Action, Safety and Effectiveness in Patients with Musculoskeletal Disorders.	Oxygen	0-6	artemin	Homo sapiens	63-66
23037895-5	2012	Here we are able to predict, using quantum mechanical methods, a small neutral molecule, (HeO)(LiF)(2), which contains a helium atom chemically bound to oxygen.	Oxygen	153-159	LIF interleukin 6 family cytokine	Homo sapiens	95-98
22936271-6	2012	PCR confirmed activation of HIF-downstream targets, GLUT1, IGF2, and VEGF under reduced O(2) levels (0.5%).	Oxygen	88-92	insulin like growth factor 2	Homo sapiens	59-63
22936271-10	2012	We concluded that gut EC cells are oxygen responsive, and alterations in O(2) levels differentially activate HIF-1alpha and tryptophan hydroxylase 1, as well as NF-kappaB signaling.	Oxygen	73-77	tryptophan hydroxylase 1	Homo sapiens	124-148
33718186-0	2021	Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck.	Oxygen	0-6	CD274 molecule	Homo sapiens	38-43
33608273-0	2021	Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.	Oxygen	86-92	telomeric repeat binding factor 1	Mus musculus	15-19
22664830-3	2012	Glomus cells, the primary site of O(2) sensing in the carotid body express heme oxygenase-2 (HO-2), a CO catalyzing enzyme.	Oxygen	34-38	heme oxygenase 2	Mus musculus	75-91
33412146-0	2021	Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-kappaB pathway.	Oxygen	41-47	sirtuin 1	Mus musculus	149-154
22664830-3	2012	Glomus cells, the primary site of O(2) sensing in the carotid body express heme oxygenase-2 (HO-2), a CO catalyzing enzyme.	Oxygen	34-38	heme oxygenase 2	Mus musculus	93-97
22664830-4	2012	HO-2 is a heme containing enzyme and has high affinity for O(2).	Oxygen	59-63	heme oxygenase 2	Mus musculus	0-4
33628589-11	2021	Importantly, the levels of DNA damage and reactive oxygen species were increased when RECQL4 was depleted.	Oxygen	51-57	RecQ like helicase 4	Homo sapiens	86-92
23081989-2	2012	Tyrosine-nitrated proteins, a footprint of oxygen- and nitrogen-derived oxidants generated by cells of the immune system, are enriched in atheromatous lesions and in circulation of patients with coronary artery disease (CAD).	Oxygen	43-49	aconitate decarboxylase 1	Homo sapiens	220-223
23025280-6	2012	A light-harvesting chlorophyll-a/b binding protein (LHCB2) was retained during the later stages of senescence in sgr1 but this was accompanied by an enhanced loss of oxygen evolving complex (OEC) subunits from PSII, which was confirmed by Western blotting, and an enhanced stability of PSII repair proteins in sgr1, compared to Col-0.	Oxygen	166-172	photosystem II light harvesting complex protein 2.3	Arabidopsis thaliana	52-57
22700222-0	2012	Molecular-dynamics simulation of dioxygen egress from 12/15-lipoxygenase-arachidonic acid complex.	Oxygen	33-41	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	54-72
33668455-9	2021	Torlon/DES-5 demonstrates high selectivity in the gas separation of O2/N2 mixture.	Oxygen	68-70	gastrin	Homo sapiens	50-53
22700222-1	2012	Extensive random-acceleration molecular-dynamics (RAMD) simulations of the egress of dioxygen (O2) from a model of rabbit 12/15-lipoxygenase-arachidonic acid complex disclosed several exit portals in addition to those previously described from implicit ligand sampling calculations and limited MD simulations.	Oxygen	85-93	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	122-140
22700222-1	2012	Extensive random-acceleration molecular-dynamics (RAMD) simulations of the egress of dioxygen (O2) from a model of rabbit 12/15-lipoxygenase-arachidonic acid complex disclosed several exit portals in addition to those previously described from implicit ligand sampling calculations and limited MD simulations.	Oxygen	95-97	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	122-140
23077033-3	2012	Since oxidative stress can increase the expression and aggregation levels of alpha-synuclein, NADPH oxidases (Noxs), which are responsible for reactive oxygen species generation, could be major players in alpha-synucleinopathy.	Oxygen	152-158	synuclein alpha	Homo sapiens	77-92
23039593-1	2012	State-to-state, collision-induced, energy transfer is followed to equilibrium through sequences of collision cycles in gas ensembles containing vibrationally excited oxygen molecules (v = 8 and 1) in several different atomic and molecular bath gases.	Oxygen	166-172	immunoglobulin superfamily member 3	Homo sapiens	184-195
33537857-2	2021	In this work, we carried out the theoretical study on the stability, activity for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), and its dependence on the electronic structure of transition metal (TM) anchored on two types of borophene (called beta12 and chi3) by density functional theory (DFT) calculations.	Oxygen	82-88	chitinase 1	Homo sapiens	277-281
23720259-4	2012	Lower partial pressure of oxygen (hypoxia), reducing the partial pressure gradient, makes gas exchange more challenging and therefore the height to which gas exchangers can travel above sea level is limited.	Oxygen	26-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	186-189
23043066-1	2012	Ceruloplasmin, a multi-copper oxidase with four active copper atoms, oxidizes Fe2+ to Fe3+ and concomittantly fully reduces oxygen to water.	Oxygen	124-130	ceruloplasmin	Homo sapiens	0-13
22884536-0	2012	Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl/6N mice.	Oxygen	53-59	tachykinin 1	Mus musculus	15-26
22543164-4	2012	Thus, incorporation of Acr(+)-Mes into nanosized mesoporous silica-alumina combined with an O(2)-reduction catalyst ([(tmpa)Cu(II)](2+)) provides a promising method in the development of efficient and robust organic photocatalysts for substrate oxygenation by dioxygen, the ultimate environmentally benign oxidant.	Oxygen	92-96	acrosin	Homo sapiens	23-26
22987635-4	2012	TAp73 deletion reduces cellular ATP levels, oxygen consumption, and mitochondrial complex IV activity, with increased ROS production and oxidative stress sensitivity.	Oxygen	44-50	transformation related protein 73	Mus musculus	0-5
23446660-5	2012	In comparison to HFHS-fed mice receiving empty plasmid, mice receiving adiponectin gene therapy displayed significantly decreased weight gain following 13 weeks of HFHS diet associated with reduced fat accumulation, and exhibited increased oxygen consumption and locomotor activity as measured by indirect calorimetry, suggesting increased energy expenditure in these mice.	Oxygen	240-246	adiponectin, C1Q and collagen domain containing	Mus musculus	71-82
22709448-0	2012	Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-beta peptide treatment.	Oxygen	66-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
22709448-2	2012	In this study, we investigated whether Src and Fyn kinases, two major members of SrcPTKs in the brain, have distinct roles in the oxygen and glucose deprivation (OGD) and amyloid-beta peptide (Abeta)-induced neuronal apoptosis.	Oxygen	130-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
22938014-14	2012	MSPCR revealed that Thy-1 became methylated following fibroblast exposure to 1% O2.	Oxygen	80-82	Thy-1 cell surface antigen	Homo sapiens	20-25
22677423-0	2012	Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.	Oxygen	9-15	eosinophil-associated, ribonuclease A family, member 1	Mus musculus	123-127
22677423-8	2012	These findings demonstrate that novel epithelial expression of Ear1 functions to limit influenza A virus infection, and its loss contributes to oxygen-associated epithelial injury and fibrosis after infection.	Oxygen	144-150	eosinophil-associated, ribonuclease A family, member 1	Mus musculus	63-67
22739762-11	2012	However, a commonly used vasopressor norepinephrine disturbs skin oxygen saturation to an extent that influences scO2.	Oxygen	66-72	synthesis of cytochrome C oxidase 2	Homo sapiens	113-117
22704999-5	2012	The previously reported kainate receptor antagonist 6-(2-carboxybenzoyl)-amino-7-chloro-3-hydroxyquinazoline-2,4-dione 3 prevented the failure of neurotransmission induced by oxygen and glucose deprivation in the CA1 region of rat hippocampal slices.	Oxygen	175-181	carbonic anhydrase 1	Rattus norvegicus	213-216
22516123-1	2012	The uptake of (18)O by scC(16)O(2) in mixtures containing liquid H(2)(18)O was followed with Raman spectroscopy using a specially designed high-pressure optical cell.	Oxygen	30-34	serpin family B member 3	Homo sapiens	23-26
22849540-3	2012	RESULTS: Here, we show that expression of adhC is maximally induced under conditions of high oxygen tension as well as specifically with glucose as a carbon source.	Oxygen	93-99	S-(hydroxymethyl)glutathione dehydrogenase	Haemophilus influenzae Rd KW20	42-46
22648409-0	2012	The Skp1 protein from Toxoplasma is modified by a cytoplasmic prolyl 4-hydroxylase associated with oxygen sensing in the social amoeba Dictyostelium.	Oxygen	99-105	S-phase kinase associated protein 1	Homo sapiens	4-8
22467849-5	2012	Hypoxic upregulation of lipin 1 expression involves predominantly HIF-1, which binds to a single distal hypoxia-responsive element in the lipin 1 gene promoter and causes its activation under low oxygen conditions.	Oxygen	196-202	lipin 1	Homo sapiens	24-31
22467849-5	2012	Hypoxic upregulation of lipin 1 expression involves predominantly HIF-1, which binds to a single distal hypoxia-responsive element in the lipin 1 gene promoter and causes its activation under low oxygen conditions.	Oxygen	196-202	lipin 1	Homo sapiens	138-145
22312019-1	2012	Oxygen-sensing prolyl-hydroxylase (PHD)-2 negatively regulates hypoxia-inducible factor (HIF)1-alpha and suppresses the hypoxic response.	Oxygen	0-6	egl-9 family hypoxia-inducible factor 1	Mus musculus	15-41
22312019-1	2012	Oxygen-sensing prolyl-hydroxylase (PHD)-2 negatively regulates hypoxia-inducible factor (HIF)1-alpha and suppresses the hypoxic response.	Oxygen	0-6	hypoxia inducible factor 1, alpha subunit	Mus musculus	63-100
22964612-1	2012	BACKGROUND: Hypoxia (3 to 5% oxygen) is essential in maintaining the plasticity of embryonic stem cells and permitting their transformation via epithelial-mesenchymal transition(EMT) and mesenchymal-epithelial transition(MET) into tissues and organs of the developing fetus.	Oxygen	29-35	IL2 inducible T cell kinase	Homo sapiens	178-181
22534037-14	2012	Expression of the oxidoreductase thioredoxin (TRX1), the second major thiol-dependent antioxidant system in eukaryotic cells, was slightly reduced, while the oxygen-sensing protein HIF-1alpha was downregulated in HEMA-exposed cell cultures.	Oxygen	158-164	hypoxia inducible factor 1, alpha subunit	Mus musculus	181-191
22950046-5	2012	SOD2, also known as MnSOD, is targeted to mitochondria and is instrumental in regulating ROS by conversion of superoxides to hydrogen peroxide, which is further broken down into H(2)O and oxygen.	Oxygen	188-194	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	0-4
22950046-5	2012	SOD2, also known as MnSOD, is targeted to mitochondria and is instrumental in regulating ROS by conversion of superoxides to hydrogen peroxide, which is further broken down into H(2)O and oxygen.	Oxygen	188-194	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	20-25
22426121-7	2012	Third, the effect of hypoxia was mediated by HIF1alpha, since the addition of an HIF1alpha inhibitor at 3% O(2) increased the number of NGN3-expressing progenitors as compared to nontreated controls (9.2-fold, P&lt;0.001).	Oxygen	107-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-54
22426121-7	2012	Third, the effect of hypoxia was mediated by HIF1alpha, since the addition of an HIF1alpha inhibitor at 3% O(2) increased the number of NGN3-expressing progenitors as compared to nontreated controls (9.2-fold, P&lt;0.001).	Oxygen	107-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	81-90
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	159-165
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	adiponectin, C1Q and collagen domain containing	Mus musculus	191-202
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	242-252
22728933-10	2012	WNT3a also increased oxygen consumption and the expression of mitochondrial genes.	Oxygen	21-27	wingless-type MMTV integration site family, member 3A	Mus musculus	0-5
22148982-0	2012	Effect of resveratrol on Bcl-2 and VEGF expression in oxygen-induced retinopathy of prematurity.	Oxygen	54-60	vascular endothelial growth factor A	Rattus norvegicus	35-39
22148982-11	2012	CONCLUSION: Resveratrol can significantly inhibit expression of Bcl-2 and VEGF in the retina of neonatal rats with oxygen-induced ROP.	Oxygen	115-121	vascular endothelial growth factor A	Rattus norvegicus	74-78
26105304-16	2012	Because oxygen diffuses more rapidly through flexible versus stiff membranes,stiff cell membranes might initiate the signaling cascade indicative of cellular hypoxia in preeclampsia with increased hypoxia inducible factor and angiogenic factors such as soluble endoglin and fms-like tyrosine kinase.	Oxygen	8-14	endoglin	Homo sapiens	261-269
22596227-4	2012	We also present protocol modifications needed for efficient recovery of MEF clones expressing p53 constructs that retain wild-type function, including growth at low (3%) oxygen and transient downregulation of p53 regulators to forestall cell senescence of primary MEFs.	Oxygen	170-176	transformation related protein 53	Mus musculus	94-97
22465476-0	2012	Myoglobin and mitochondria: a relationship bound by oxygen and nitric oxide.	Oxygen	52-58	myoglobin	Homo sapiens	0-9
22465476-3	2012	Likewise, myoglobin, traditionally thought of only as an oxygen store, has emerged as a physiological catalyst that can modulate reactive oxygen species levels, facilitate oxygen diffusion and scavenge or generate nitric oxide (NO) depending on oxygen tensions within the cell.	Oxygen	57-63	myoglobin	Homo sapiens	10-19
22465476-3	2012	Likewise, myoglobin, traditionally thought of only as an oxygen store, has emerged as a physiological catalyst that can modulate reactive oxygen species levels, facilitate oxygen diffusion and scavenge or generate nitric oxide (NO) depending on oxygen tensions within the cell.	Oxygen	138-144	myoglobin	Homo sapiens	10-19
22465476-3	2012	Likewise, myoglobin, traditionally thought of only as an oxygen store, has emerged as a physiological catalyst that can modulate reactive oxygen species levels, facilitate oxygen diffusion and scavenge or generate nitric oxide (NO) depending on oxygen tensions within the cell.	Oxygen	138-144	myoglobin	Homo sapiens	10-19
22465476-4	2012	By virtue of its unique ability to regulate O(2) and NO levels within the cell, myoglobin can modulate mitochondrial function in energy-demanding tissues such as the beating heart and exercising muscle.	Oxygen	44-48	myoglobin	Homo sapiens	80-89
22465476-6	2012	We present the mechanisms by which mitochondria and myoglobin regulate one another within the cell through their interactions with NO and oxygen and discuss the implications of these interactions in terms of health and disease.	Oxygen	138-144	myoglobin	Homo sapiens	52-61
22552282-11	2012	These data demonstrate that oxygen regulates Mcl-1 and p53 stability during placentation via HIF-1-controlled MULE expression.	Oxygen	28-34	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	45-50
22367737-0	2012	Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion.	Oxygen	12-18	transformation related protein 53, pseudogene	Mus musculus	108-111
22367737-4	2012	Herein, we demonstrate that exposure to atmospheric oxygen rapidly induced p53, TOP2A, and BCL2-associated X protein (BAX) expression and mitochondrial reactive oxygen species (ROS) generation in primary mouse MSCs resulting in oxidative stress, reduced cell viability, and inhibition of cell proliferation.	Oxygen	52-58	transformation related protein 53, pseudogene	Mus musculus	75-78
22367737-4	2012	Herein, we demonstrate that exposure to atmospheric oxygen rapidly induced p53, TOP2A, and BCL2-associated X protein (BAX) expression and mitochondrial reactive oxygen species (ROS) generation in primary mouse MSCs resulting in oxidative stress, reduced cell viability, and inhibition of cell proliferation.	Oxygen	52-58	topoisomerase (DNA) II alpha	Mus musculus	80-85
22367737-5	2012	Alternatively, procurement and culture in 5% oxygen supported more prolific expansion of the CD45(-ve) /CD44(+ve) cell fraction in marrow, produced increased MSC yields following immunodepletion, and supported sustained MSC growth resulting in a 2,300-fold increase in cumulative cell yield by fourth passage.	Oxygen	45-51	protein tyrosine phosphatase, receptor type, C	Mus musculus	93-97
22367737-7	2012	The oxygen-induced stress response was dependent upon p53 since siRNA-mediated knockdown of p53 in wild-type cells or exposure of p53(-/-) MSCs to atmospheric oxygen failed to induce ROS generation, reduce viability, or arrest cell growth.	Oxygen	4-10	transformation related protein 53, pseudogene	Mus musculus	54-57
22367737-7	2012	The oxygen-induced stress response was dependent upon p53 since siRNA-mediated knockdown of p53 in wild-type cells or exposure of p53(-/-) MSCs to atmospheric oxygen failed to induce ROS generation, reduce viability, or arrest cell growth.	Oxygen	4-10	transformation related protein 53, pseudogene	Mus musculus	92-95
22367737-7	2012	The oxygen-induced stress response was dependent upon p53 since siRNA-mediated knockdown of p53 in wild-type cells or exposure of p53(-/-) MSCs to atmospheric oxygen failed to induce ROS generation, reduce viability, or arrest cell growth.	Oxygen	4-10	transformation related protein 53, pseudogene	Mus musculus	92-95
22367737-8	2012	These data indicate that long-term culture expansion of mouse MSCs in atmospheric oxygen selects for clones with absent or impaired p53 function, which allows cells to escape oxygen-induced growth inhibition.	Oxygen	82-88	transformation related protein 53, pseudogene	Mus musculus	132-135
22367737-8	2012	These data indicate that long-term culture expansion of mouse MSCs in atmospheric oxygen selects for clones with absent or impaired p53 function, which allows cells to escape oxygen-induced growth inhibition.	Oxygen	175-181	transformation related protein 53, pseudogene	Mus musculus	132-135
22367737-9	2012	In contrast, expansion in 5% oxygen generates large numbers of primary mouse MSCs that retain sensitivity to atmospheric oxygen, and therefore a functional p53 protein, even after long-term expansion in vitro.	Oxygen	29-35	transformation related protein 53, pseudogene	Mus musculus	156-159
22498030-12	2012	GRB10 methylation is also correlated with genes involved in reactive oxygen species signaling, stress signaling and oxygen sensing and more recent data implicate GRB10 in insulin signaling.	Oxygen	69-75	growth factor receptor bound protein 10	Homo sapiens	0-5
22286776-8	2012	Under both oxygen tensions, Hsp90 inhibition downregulated the cell cycle-associated proteins, Cdk1, Cdk4 and pRb.	Oxygen	11-17	heat shock protein 90 alpha family class A member 1	Homo sapiens	28-33
22286776-8	2012	Under both oxygen tensions, Hsp90 inhibition downregulated the cell cycle-associated proteins, Cdk1, Cdk4 and pRb.	Oxygen	11-17	cyclin dependent kinase 1	Homo sapiens	95-99
22540597-6	2012	Carbon and oxygen atoms are arranged in CO4 tetrahedral units linked by oxygen atoms at the corners.	Oxygen	11-17	complement C4A (Rodgers blood group)	Homo sapiens	40-43
22342720-2	2012	We analysed the expression of the thioredoxin system in the MDA-MB-231 breast cancer cell line under conditions mimicking the tumor oxygen microenvironment.	Oxygen	132-138	thioredoxin	Homo sapiens	34-45
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	212-217
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	233-238
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	255-260
22230249-5	2012	Here, we show that STAT3 was activated by increased retinal VEGF in the rat 50/10 oxygen-induced retinopathy model.	Oxygen	82-88	signal transducer and activator of transcription 3	Rattus norvegicus	19-24
22230249-5	2012	Here, we show that STAT3 was activated by increased retinal VEGF in the rat 50/10 oxygen-induced retinopathy model.	Oxygen	82-88	vascular endothelial growth factor A	Rattus norvegicus	60-64
22092659-5	2012	cbbM genes were not expressed in the oxygen-amended groundwater, probably due to the low CO(2) /O(2)  substrate specificity of this enzyme.	Oxygen	37-43	opsin 1, medium wave sensitive	Homo sapiens	0-4
22360213-2	2012	Four dominant local oxygen topologies are identified based on the coordination environment: M-O-M and M-O-P bridges for the oxygen-decorated surface; and M-[OH]-M bridges and atop M-OH structures for the hydroxyl-decorated surface (M = In, Ga).	Oxygen	20-26	neurolysin	Homo sapiens	102-107
22288842-10	2012	The cardiac output was significantly higher in the Alb group than in the others, indicating compensation for low oxygen delivery per unit blood.	Oxygen	113-119	albumin	Canis lupus familiaris	51-54
22055239-2	2012	The suggestion that the interaction between the hydrogen bond donor site H1 with the 3-carbonyl oxygen in 3-carbonylquinolin-4-ones can be replaced by an interaction between H1 and N-2 in the isothiazoloquinolin-4-ones, was confirmed.	Oxygen	96-102	H1.5 linker histone, cluster member	Homo sapiens	174-184
21987385-1	2012	Studies of many cell types show that levels of hypoxia inducible factor (HIF)-1alpha and HIF-2alpha are primarily controlled by oxygen-dependent proteasomal degradation, catalyzed by HIF prolyl-hydroxylases (PHDs).	Oxygen	128-134	endothelial PAS domain protein 1	Homo sapiens	89-99
21987385-9	2012	Importantly, our data clearly suggests that proteasomal degradation of HIF-2alpha is not mediated by a classical oxygen-dependent PHD pathway.	Oxygen	113-119	endothelial PAS domain protein 1	Homo sapiens	71-81
22061780-1	2012	Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a protective cellular oxygen-sensing response in part through the stabilization and activation of the Hypoxia Inducible Factor (HIF) 1alpha transcription factor.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-229
22061780-1	2012	Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a protective cellular oxygen-sensing response in part through the stabilization and activation of the Hypoxia Inducible Factor (HIF) 1alpha transcription factor.	Oxygen	112-118	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-229
22061780-2	2012	The present investigation tested the therapeutic potential of enhanced activation of oxygen-sensing pathways by competitive pharmacologic PHD inhibition after stroke, hypothesizing that post-ischemic PHD inhibition would reduce neuronal cell death and require the activation of HIF-1alpha.	Oxygen	85-91	hypoxia inducible factor 1, alpha subunit	Mus musculus	278-288
22048469-1	2012	Hypoxia inducible factor-1alpha (HIF-1alpha), a ubiquitous inducible oxygen-sensing transcription factor, promotes cell survival under hypoxic conditions, including the early pre-angiogenic period of tumorigenesis, and is known to contribute to many malignancies.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
22048469-1	2012	Hypoxia inducible factor-1alpha (HIF-1alpha), a ubiquitous inducible oxygen-sensing transcription factor, promotes cell survival under hypoxic conditions, including the early pre-angiogenic period of tumorigenesis, and is known to contribute to many malignancies.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
22041888-2	2012	The X-ray structural analysis exhibits that the three complexes show similar mononuclear structures, in which NIT-2Py radical chelates the Ln(III) ion through the oxygen atom of the NO group and the nitrogen atom from the pyridine ring.	Oxygen	163-169	nitrilase family member 2	Homo sapiens	110-115
22104347-3	2012	Recent works have shown that various growth factors and cytokines including IGF-1 can stimulate HIF-1alpha expression, thereby triggering transcription of numerous hypoxia-inducible genes by oxygen-independent mechanisms.	Oxygen	191-197	insulin-like growth factor 1	Rattus norvegicus	76-81
22706241-3	2012	Mitochondrial ferritin (FtMt), an iron-sequestering protein, is expressed in cell types characterized by high metabolic activity and oxygen consumption, including human retina, suggesting a role in protecting mitochondria from iron-dependent oxidative damage.	Oxygen	133-139	ferritin mitochondrial	Homo sapiens	24-28
22075967-10	2012	CONCLUSIONS: Myocardial p53/SCO2 signal is activated by diabetes-mediated ROS generation to increase mitochondrial oxygen consumption, resulting in excessive generation of mitochondria-derived ROS and lipid accumulation in association with cardiac dysfunction.	Oxygen	115-121	transformation related protein 53, pseudogene	Mus musculus	24-27
22075967-10	2012	CONCLUSIONS: Myocardial p53/SCO2 signal is activated by diabetes-mediated ROS generation to increase mitochondrial oxygen consumption, resulting in excessive generation of mitochondria-derived ROS and lipid accumulation in association with cardiac dysfunction.	Oxygen	115-121	SCO2 cytochrome c oxidase assembly protein	Mus musculus	28-32
21895695-6	2012	Moreover, all Galpha-, Gbeta1- and Gbeta2-silenced plants significantly impaired elicitor-induced stomatal closure, elicitor-promoted nitric oxide (NO) production and active oxygen species accumulation in guard cells.	Oxygen	174-180	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	14-20
23226354-8	2012	Additionally, TrxR2 deficient cells showed decreased basal mitochondrial oxygen consumption rates.	Oxygen	73-79	thioredoxin reductase 2	Rattus norvegicus	14-19
23029459-3	2012	Cross-talk between E. coli FadR and the ArcA-ArcB oxygen-responsive two-component system was observed that resulted in diverse regulation of certain fad regulon beta-oxidation genes.	Oxygen	50-56	hypothetical protein	Escherichia coli	45-49
22701626-5	2012	Metabolic analysis revealed increases in rectal body temperature and minimum oxygen consumption in 12-13 week old homozygous Cln3(Deltaex7/8) mice, which were also seen to a lesser extent in heterozygous Cln3(Deltaex7/8) mice.	Oxygen	77-83	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	125-129
22662171-3	2012	Loss of PINK1 function causes mitochondrial dysfunction, increased reactive oxygen species production and calcium dysregulation, which increases susceptibility to neuronal death in Parkinson"s disease.	Oxygen	76-82	PTEN induced putative kinase 1	Mus musculus	8-13
23259746-4	2012	HIF transcription factors are members of the Per-ARNT-Sim (PAS) family of heterodimeric basic helix-loop-helix transcription factors and consist of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-unit, also known as the aryl-hydrocarbon-receptor nuclear translocator (ARNT) or HIF-beta.	Oxygen	151-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	49-53
23259746-4	2012	HIF transcription factors are members of the Per-ARNT-Sim (PAS) family of heterodimeric basic helix-loop-helix transcription factors and consist of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-unit, also known as the aryl-hydrocarbon-receptor nuclear translocator (ARNT) or HIF-beta.	Oxygen	151-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	242-288
23259746-4	2012	HIF transcription factors are members of the Per-ARNT-Sim (PAS) family of heterodimeric basic helix-loop-helix transcription factors and consist of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-unit, also known as the aryl-hydrocarbon-receptor nuclear translocator (ARNT) or HIF-beta.	Oxygen	151-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	290-294
23259746-4	2012	HIF transcription factors are members of the Per-ARNT-Sim (PAS) family of heterodimeric basic helix-loop-helix transcription factors and consist of an oxygen-sensitive alpha-subunit and a constitutively expressed beta-unit, also known as the aryl-hydrocarbon-receptor nuclear translocator (ARNT) or HIF-beta.	Oxygen	151-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	299-307
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Oxygen	272-278	microRNA 222	Homo sapiens	110-117
22577772-0	2012	Involvement of CD24 in angiogenesis in a mouse model of oxygen-induced retinopathy.	Oxygen	56-62	CD24a antigen	Mus musculus	15-19
22577772-1	2012	PURPOSE: To investigate a possible involvement of CD24 in vascular remodeling and angiogenesis in retinopathy of prematurity (ROP) in a mouse model of oxygen-induced retinopathy.	Oxygen	151-157	CD24a antigen	Mus musculus	50-54
22856306-4	2012	Moreover, when the urea was loaded on CA, a catalyst containing 40% urea/ACF loaded with 10% CeO2 (UCA4) could yield a NO(x) conversion of about 80% for 24.5 h. Based on the experimental results, the catalytic mechanisms of SCR with and without oxygen are discussed.	Oxygen	245-251	ACF	Homo sapiens	73-76
22715431-4	2012	Here, we used polyethylene glycol-conjugated D-amino acid oxidase (PEG-DAO) as an H(2)O(2) source.	Oxygen	85-90	D-amino acid oxidase	Homo sapiens	71-74
22715431-5	2012	The enzyme DAO generates H(2)O(2) by using D-amino acid and oxygen as substrates.	Oxygen	60-66	D-amino acid oxidase	Homo sapiens	11-14
22666407-3	2012	The pharmacophore model indicates that HBA3 is an essential feature for the oxygen atom of 5-OH in 6a-b and for the carbonyl group of 5-OCOCH(3) in 7a-b, important for their cytotoxic properties.	Oxygen	76-82	hemoglobin subunit alpha pseudogene 1	Homo sapiens	39-43
33603672-13	2021	Ga and the JNK inhibitor, sp600125, markedly suppressed Px-12-induced generation of intracellular ROS and O2 -.	Oxygen	106-110	mitogen-activated protein kinase 8	Rattus norvegicus	11-14
22428001-3	2012	For activity, ARSB requires modification of a critical cysteine residue by the formylglycine generating enzyme and by molecular oxygen.	Oxygen	128-134	arylsulfatase B	Homo sapiens	14-18
22428001-4	2012	When primary human bronchial and human colonic epithelial cells were exposed to 10% O(2) x 1 h, ARSB activity declined by ~41% and ~30% from baseline, as nuclear hypoxia inducible factor (HIF)-1alpha increased by ~53% and ~37%.	Oxygen	84-88	arylsulfatase B	Homo sapiens	96-100
22623105-9	2012	Moreover, the ethanol assay and the oxygen consumption measurement demonstrated a fermentative activity in SCO1 mutant on respiratory medium.	Oxygen	36-42	Cu-binding protein SCO1	Saccharomyces cerevisiae S288C	107-111
22741040-6	2012	PFKFB3 overexpression in DB-1 tumor cells induced a high rate of glycolysis and inhibited oxygen consumption, confirming its role in controlling glycolytic flux.	Oxygen	90-96	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	0-6
22678294-7	2012	We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.	Oxygen	77-83	endothelial PAS domain protein 1	Homo sapiens	94-125
22678294-7	2012	We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.	Oxygen	77-83	endothelial PAS domain protein 1	Homo sapiens	127-137
22678294-7	2012	We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue.	Oxygen	77-83	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	189-195
22323633-0	2012	Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons.	Oxygen	98-104	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	14-30
22442717-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: FAAH(-/-) mice exhibit altered energy homeostasis demonstrated by decreased oxygen consumption (Indirect calorimetry).	Oxygen	108-114	fatty acid amide hydrolase	Mus musculus	32-36
23037695-6	2012	When mice or mouse cells were treated with bisphenol A, an endocrine disruptor and inducer of reactive oxygen species, DJ-1 was translocated into mitochondria to maintain mitochondrial complex I activity.	Oxygen	103-109	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	119-123
33540619-0	2021	Oxygen-Deficient Stannic Oxide/Graphene for Ultrahigh-Performance Supercapacitors and Gas Sensors.	Oxygen	0-6	gastrin	Homo sapiens	86-89
33252251-5	2021	We confirmed the reciprocal action of these synthetic RORa ligands on gene expression, mitochondrial mass and uncoupled oxygen consumption rate in cultured murine and human adipocytes.	Oxygen	120-126	RAR-related orphan receptor alpha	Mus musculus	54-58
22134239-0	2011	Oxygen sensing is impaired in ATM-defective cells.	Oxygen	0-6	ATM serine/threonine kinase	Homo sapiens	30-33
22508027-6	2012	Compared to Htt(7Q/7Q) NS cells, HD Htt(140Q/140Q) NS cells showed significantly reduced levels of cholesterol, increased levels of reactive oxygen species (ROS), and impaired motility.	Oxygen	141-147	huntingtin	Mus musculus	36-39
33337958-11	2021	In AGAT KO mice, which are a model of pure creatine-deficiency, the changes in HK may reflect changes in metabolism as well as influence mitochondrial regulation and reactive oxygen species production.	Oxygen	175-181	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	Mus musculus	3-7
22306110-0	2012	The effects of ROS-mediating oxygen tension on human CD34(+)CD38(-) cells induced into mature dendritic cells.	Oxygen	29-35	CD38 molecule	Homo sapiens	60-64
22158683-2	2011	The formation of an acyclic boronate ester by the attachment of a hydride ion at C-1 indicated that the unexpected endocyclic cleavage of the bond between the anomeric carbon atom and the pyranose ring oxygen atom proceeded via an oxacarbenium ion intermediate produced by the chelation between O5/O6 of the pyranoside and the Lewis acid, followed by nucleophile substitution with a hydride ion at C1.	Oxygen	202-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	81-84
33130089-3	2021	OMA1 is dormant under physiological conditions but rapidly activated upon mitochondrial stress, such as loss of membrane potential or excessive reactive oxygen species.	Oxygen	153-159	OMA1 zinc metallopeptidase	Homo sapiens	0-4
22138754-6	2011	Our findings suggest that PDGF-BB-induced EPO promotes tumor growth through two mechanisms: first, paracrine stimulation of tumor angiogenesis by direct induction of endothelial cell proliferation, migration, sprouting and tube formation, and second, endocrine stimulation of extramedullary hematopoiesis leading to increased oxygen perfusion and protection against tumor-associated anemia.	Oxygen	326-332	erythropoietin	Mus musculus	42-45
22131314-4	2011	Under conditions associated with acute or chronic oxygen deprivation, PPAR-alpha modulates expression of genes that determine substrate switch (FA vs. glucose) aimed at maintenance of basic cardiac function.	Oxygen	50-56	peroxisome proliferator activated receptor alpha	Homo sapiens	70-80
22356887-0	2012	Genomic analysis of [d-Ala2, d-Leu5] enkephalin preconditioning in cortical neuron and glial cell injury after oxygen deprivation.	Oxygen	111-117	proenkephalin	Rattus norvegicus	37-47
22094978-6	2012	The ratio of dissolved oxygen to ammonium loading rate (DO/ALR) was critical to maintain high ammonium removal efficiency and nitrite accumulation ratio.	Oxygen	23-29	growth factor, augmenter of liver regeneration	Homo sapiens	59-62
33493769-6	2021	Since HIF-1alpha signaling is conserved across species, environmental or pharmacological manipulation of oxygen-dependent pathways may elicit a regenerative response in non-healing mammals.	Oxygen	105-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	6-16
22426208-2	2012	The oxygen-responsive transcriptional regulator hypoxia-inducible factor 2alpha (HIF-2alpha) is highly expressed in vascular ECs and, along with HIF-1alpha, activates expression of target genes whose products modulate vascular functions and angiogenesis.	Oxygen	4-10	endothelial PAS domain protein 1	Mus musculus	48-79
22426208-2	2012	The oxygen-responsive transcriptional regulator hypoxia-inducible factor 2alpha (HIF-2alpha) is highly expressed in vascular ECs and, along with HIF-1alpha, activates expression of target genes whose products modulate vascular functions and angiogenesis.	Oxygen	4-10	endothelial PAS domain protein 1	Mus musculus	81-91
22426208-2	2012	The oxygen-responsive transcriptional regulator hypoxia-inducible factor 2alpha (HIF-2alpha) is highly expressed in vascular ECs and, along with HIF-1alpha, activates expression of target genes whose products modulate vascular functions and angiogenesis.	Oxygen	4-10	hypoxia inducible factor 1, alpha subunit	Mus musculus	145-155
22080867-2	2011	Control of physiologic and pathologic erythropoiesis is dependent predominantly on erythropoietin (EPO), the expression of which is regulated by hypoxia-inducible factor (HIF) activity in response to low oxygen tension.	Oxygen	204-210	erythropoietin	Mus musculus	83-97
22080867-2	2011	Control of physiologic and pathologic erythropoiesis is dependent predominantly on erythropoietin (EPO), the expression of which is regulated by hypoxia-inducible factor (HIF) activity in response to low oxygen tension.	Oxygen	204-210	erythropoietin	Mus musculus	99-102
33508746-10	2021	INTERPRETATION: Renal interstitial fibroblasts function as central controllers of systemic oxygen delivery by producing both renin and erythropoietin.	Oxygen	91-97	erythropoietin	Mus musculus	135-149
21988318-0	2011	Antiangiogenic effects of beta2 -adrenergic receptor blockade in a mouse model of oxygen-induced retinopathy.	Oxygen	82-88	adrenergic receptor, beta 2	Mus musculus	26-52
22252129-4	2012	Either hypoxia or mutations in egl-9, a prolyl hydroxylase cellular oxygen sensor, result in the internalization of GLR-1, the reduction of glutamate-activated currents, and the depression of GLR-1-mediated behaviours.	Oxygen	68-74	Glutamate receptor 1	Caenorhabditis elegans	116-121
22252129-4	2012	Either hypoxia or mutations in egl-9, a prolyl hydroxylase cellular oxygen sensor, result in the internalization of GLR-1, the reduction of glutamate-activated currents, and the depression of GLR-1-mediated behaviours.	Oxygen	68-74	Glutamate receptor 1	Caenorhabditis elegans	192-197
22299646-4	2012	The active species to react with O(2) in the catalytic reaction is switched from Co(II)(Ph(8)Pc) to protonated Co(I)(Ph(8)PcH), depending on the reducing ability of ferrocene derivatives employed.	Oxygen	33-37	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	111-116
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	212-217
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	233-238
22162090-0	2012	VEGF-independent cell-autonomous functions of HIF-1alpha regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.	Oxygen	68-74	hypoxia inducible factor 1, alpha subunit	Mus musculus	46-56
22162090-10	2012	These findings suggest that HIF-1alpha activates VEGF-independent cell-autonomous mechanisms to sustain oxygen levels in the challenged avascular cartilage by reducing oxygen consumption.	Oxygen	104-110	hypoxia inducible factor 1, alpha subunit	Mus musculus	28-38
22162090-10	2012	These findings suggest that HIF-1alpha activates VEGF-independent cell-autonomous mechanisms to sustain oxygen levels in the challenged avascular cartilage by reducing oxygen consumption.	Oxygen	168-174	hypoxia inducible factor 1, alpha subunit	Mus musculus	28-38
22162090-12	2012	We conclude that VEGF and HIF-1alpha are critical preservers of chondrocyte survival by ensuring an adequate balance between availability and handling of oxygen in developing growth cartilage.	Oxygen	154-160	hypoxia inducible factor 1, alpha subunit	Mus musculus	26-36
22042285-8	2011	Hemoglobin Bart"s is nonfunctional for oxygen transport, and intrauterine exchange transfusion may be effective first-line therapy and further investigation is warranted.	Oxygen	39-45	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	11-15
21658409-5	2011	Compared with untransfected SH-SY5Y cells, wild type alpha-Syn attenuated rotenone and maneb-induced cell death along with an attenuation of toxin-induced mitochondrial membrane potential changes and Reactive Oxygen Species level, whereas the mutant alpha-Syn constructs exacerbated environmental toxins-induced cytotoxicity.	Oxygen	209-215	synuclein alpha	Homo sapiens	53-62
22055192-0	2011	Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha.	Oxygen	0-6	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-95
22055192-3	2011	Here, we show that p75 neurotrophin receptor (p75(NTR)) undergoes hypoxia-induced gamma-secretase-dependent cleavage to provide a positive feed-forward mechanism required for oxygen-dependent HIF-1alpha stabilization.	Oxygen	175-181	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-202
33484475-9	2021	Mitochondrial oxygen consumption decreased in response to SK1 degradation, and this was accompanied by an increase in intracellular reactive oxygen species (ROS).	Oxygen	14-20	sphingosine kinase 1	Homo sapiens	58-61
21944269-10	2012	Oxygen consumption increased faster (both tests) and to higher values (acute exercise) in Plin1(-/-) mice.	Oxygen	0-6	perilipin 1	Mus musculus	90-95
32029507-7	2021	Stable knockdown of ATM in Jeko-1 and Mino cells conferred resistance to mitophagy and was associated with reduced ATP production, oxygen consumption, and increased mROS.	Oxygen	131-137	ATM serine/threonine kinase	Homo sapiens	20-23
21964491-12	2012	As expected, oxygen breathing induced a pronounced vasoconstriction and a decrease red and white cell flux in both, the placebo and the G-CSF group (p&lt;0.01 for both groups).	Oxygen	13-19	colony stimulating factor 3	Homo sapiens	136-141
22611923-8	2012	Decreasing the active oxygen generation may be one of the mechanism of the protective effects on LLC-PK1 by ALA.	Oxygen	22-28	pyruvate kinase L/R	Rattus norvegicus	101-104
33565273-12	2021	Oscillating oxygen in the hypoxic/hyperoxic range has a characteristical impact on vasoactive mediators like NOS3 and on the activation of the renin-angiotensin system in the lung endothelium.	Oxygen	12-18	nitric oxide synthase 3, endothelial cell	Mus musculus	109-113
22147261-8	2012	In particular, cells expressing closed, inactive Ezrin exhibited reduced lactate production and basal or ATP-dependent oxygen consumption.	Oxygen	119-125	ezrin	Homo sapiens	49-54
22361433-7	2012	MEF2C gene targets myozenin and myoglobin as well as myokinase were also altered during cachexia, suggesting dysregulated oxygen transport capacity and ATP regeneration in addition to distorted structural integrity.	Oxygen	122-128	myocyte enhancer factor 2C	Homo sapiens	0-5
33501731-8	2021	Furthermore, the generation of the reactive oxygen species was responsible for PBMT-induced activation of Src and its downstream target effects.	Oxygen	44-50	Rous sarcoma oncogene	Mus musculus	106-109
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	Oxygen	111-117	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	40-45
22112784-2	2012	Previously, we reported that GM-CSF inhalation therapy improved alveolar-arterial oxygen difference and serum biomarkers of disease severity in these patients.	Oxygen	82-88	colony stimulating factor 2	Homo sapiens	29-35
22128189-0	2012	Skp1 prolyl 4-hydroxylase of dictyostelium mediates glycosylation-independent and -dependent responses to O2 without affecting Skp1 stability.	Oxygen	106-108	S-phase kinase associated protein 1	Homo sapiens	0-4
32916576-0	2021	Fe-modified Co2(OH)3Cl microspheres for highly efficient oxygen evolution reaction.	Oxygen	57-63	complement C2	Homo sapiens	12-15
22490689-9	2012	Serum A-FABP level was positively correlated with AHI and the time of oxygen saturation (SaO2) &lt; 90% (r = 0.231, P = 0.042 and r = 0.226, P = 0.047).	Oxygen	70-76	fatty acid binding protein 4	Homo sapiens	6-12
32916576-4	2021	Fe doping into Co2(OH)3Cl lattices can make the etching of surface lattice Cl- easier and generate more surface vacancies to absorb oxygen species.	Oxygen	132-138	complement C2	Homo sapiens	15-18
33300026-7	2021	Intriguingly, from the evolutionarily conserved unstructured domain that targets NEIL1 to open chromatin, its damage surveillance of highly oxidation-susceptible sites to preserve essential gene function and to limit instability and cancer likely originated ~500 million years ago during the buildup of free atmospheric oxygen.	Oxygen	320-326	nei like DNA glycosylase 1	Homo sapiens	81-86
22045254-2	2012	Previously we found that primary neurons from embryonic cortex of mice bearing the Huntington"s disease mutation (140 glutamines inserted into exon 1 of huntingtin) showed higher levels of reactive oxygen species before cell death.	Oxygen	198-204	huntingtin	Mus musculus	153-163
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	collagen type III alpha 1 chain	Rattus norvegicus	274-299
22729862-1	2012	During evolution from prokaryotes to eukaryotes, the main function of cytochrome c oxidase (COX), i.e., the coupling of oxygen reduction to proton translocation without the production of ROS (reactive oxygen species) remained unchanged demonstrating its robustness.	Oxygen	120-126	coproporphyrinogen oxidase	Rattus norvegicus	92-95
23080142-2	2012	Previous work from our laboratory demonstrated that 1-2 weeks of hyperoxia (60% O(2)) starting between P1 and P14: reduced the single chemoreceptor unit response to hypoxia, reduced the rise in glomus cell calcium caused by acute hypoxia and reduced hypoxia-induced catecholamine release (Donnelly 05, Donnelly 09).	Oxygen	80-84	perforin 1	Rattus norvegicus	103-113
21409388-4	2012	In that sense, oxygen, electrophilic agents, and bacterial lipopolysaccharide trigger xCT expression to accommodate with increased oxidative stress by stimulating GSH biosynthesis.	Oxygen	15-21	solute carrier family 7 member 11	Homo sapiens	86-89
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	collagen type III alpha 1 chain	Rattus norvegicus	301-311
21794046-0	2012	Caveolin-1 expression regulates blood-retinal barrier permeability and retinal neovascularization in oxygen-induced retinopathy.	Oxygen	101-107	caveolin 1, caveolae protein	Mus musculus	0-10
33488404-12	2020	Oxygen enrichment inhibited medial thickening, stenosis and fibrosis of pulmonary arterioles, and cytokine expression related with fibrosis (Col1alpha1, Col3alpha1, and hydroxyproline) and pulmonary vasoconstriction [endothelin-1(ET-1)] in HAH-exposed rats.	Oxygen	0-6	collagen type III alpha 1 chain	Rattus norvegicus	153-163
21794046-8	2012	siRNA against caveolin-1 was injected intravitreally in the oxygen-induced retinopathy models.	Oxygen	60-66	caveolin 1, caveolae protein	Mus musculus	14-24
33488380-8	2020	These data demonstrate that supraphysiological oxygen exposure during the critical neonatal developmental period leads to pathologically heightened CA3-CA1 synaptic function during early adulthood which may contribute to hippocampal shrinkage and learning and memory deficits we previously reported.	Oxygen	47-53	carbonic anhydrase 1	Mus musculus	152-155
32988222-10	2021	Mechanism studies revealed that PCSK9 binds to platelet CD36 and thus activates Src kinase and mitogen-activated protein kinase (MAPK)- extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase, increases the generation of reactive oxygen species, as well as activates the p38MAPK/cytosolic phospholipase A2/cyclooxygenase-1/thromboxane A2 signaling pathways downstream of CD36 to enhance platelet activation.	Oxygen	242-248	proprotein convertase subtilisin/kexin type 9	Homo sapiens	32-37
22731388-3	2012	The syn oxygen atom of the carboxylic group attacks the alpha-phosphorous atom (alphaP) of ATP in all class I aaRSs (except TrpRS) investigated, while the anti oxygen atom attacks in the case of class II aaRSs.	Oxygen	8-14	tryptophanyl tRNA synthetase 2, mitochondrial	Homo sapiens	124-129
22701736-3	2012	A multifactorial approach was developed to rationally evaluate the singular and interactive control of MEK/ERK pathway, GSK-3 inhibition, and LIF/STAT3 signaling at physiological and non-physiological oxygen tensions.	Oxygen	201-207	LIF interleukin 6 family cytokine	Homo sapiens	142-145
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	NLR family, pyrin domain containing 3	Mus musculus	163-168
23133378-3	2012	We show that oxygen consumption rates (OCR) and egg production are significantly diminished by pharmacologic inhibition of carnitine palmitoyl transferase 1 (CPT1), which catalyzes a rate limiting step in fatty acid beta-oxidation (FAO) and by genetic loss of function of acyl CoA synthetase, which complexes with CPT1 and activates long chain FA for use in FAO, and of acyl CoA dehydrogenase, which catalyzes the first step in FAO within mitochondria.	Oxygen	13-19	acyl-CoA dehydrogenase	Schistosoma mansoni	370-392
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	interleukin 1 alpha	Mus musculus	262-270
31145050-6	2021	Nevertheless, O2, inorganic ions and NOM exerted a negative effect on CCl4 degradation and the removal efficiency of CCl4 in groundwater was only 31.7%.	Oxygen	14-16	C-C motif chemokine ligand 4	Homo sapiens	70-74
22441344-0	2012	Effect of moderate elevation above sea level on blood oxygen saturation in healthy young adults.	Oxygen	54-60	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
22100406-0	2011	Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
31145050-6	2021	Nevertheless, O2, inorganic ions and NOM exerted a negative effect on CCl4 degradation and the removal efficiency of CCl4 in groundwater was only 31.7%.	Oxygen	14-16	C-C motif chemokine ligand 4	Homo sapiens	117-121
33368638-7	2021	Indeed, pitp-1 mutants display wild-type-like O2 -evoked-calcium responses in the URX O2 -sensing neuron.	Oxygen	46-48	DDHD domain-containing protein	Caenorhabditis elegans	8-14
24061129-6	2011	Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.	Oxygen	295-301	glutathione-disulfide reductase	Rattus norvegicus	7-10
33390812-5	2021	In addition, an inhibitor assay revealed that production of reactive oxygen species, P2X7R activity, and release of cathepsin B are involved in IL-1beta production in BMDCs in response to P. nigrescens.	Oxygen	69-75	interleukin 1 alpha	Homo sapiens	144-152
22031289-0	2011	Low oxygen levels induce the expression of the embryonic morphogen Nodal.	Oxygen	4-10	nodal growth differentiation factor	Homo sapiens	67-72
22031289-6	2011	The oxygen-mediated regulation of Nodal expression occurs via a combinatorial mechanism.	Oxygen	4-10	nodal growth differentiation factor	Homo sapiens	34-39
32876043-4	2021	RESULTS: The logarithm of the time of oxygen saturation below 90% (CT90) significantly predicted AA and MPA sizes in all patients with OSA (p < 0.05).	Oxygen	38-44	kinesin family member 20B	Homo sapiens	67-71
21924895-0	2011	Dissolved methane oxidation and competition for oxygen in down-flow hanging sponge reactor for post-treatment of anaerobic wastewater treatment.	Oxygen	48-54	solute carrier family 35 member G1	Homo sapiens	95-99
32557145-0	2021	Naringin Targets NFKB1 to Alleviate Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in PC12 Cells Via Modulating HIF-1alpha/AKT/mTOR-Signaling Pathway.	Oxygen	36-42	nuclear factor kappa B subunit 1	Rattus norvegicus	17-22
32644208-0	2021	Erythropoietin-induced hemoglobin subunit beta may stimulate innate immune RNA virus pattern recognition, suppress reactive oxygen species, reduce ACE2 viral doorway opening, and neutrophil extracellular traps against COVID-19.	Oxygen	124-130	hemoglobin subunit beta	Homo sapiens	23-46
32304604-6	2021	During the electrochemical oxidation process, the PbO2 -Ti4 O7 (1.0) electrode showed the best performance on degradation of AR1 (i.e. the highest removal efficiency and the lowest energy consumption), which could be attributed to its high oxygen evolution potential (OEP) and strong capability of HO  generation.	Oxygen	240-246	transcription factor 20	Homo sapiens	125-128
33046676-9	2020	These changes in H2O2 and O2 - in yeasts were altered by reductants or inhibitors of scavenging enzyme by means of regulating the expression of ATG11 and ATG32 genes.	Oxygen	19-21	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	154-159
33046676-10	2020	Inhibitors of the mitochondrial electron transport chain (mtETC) also increased production of H2O2 and O2 - by enhancing expression of the ATG11 and ATG32 genes.	Oxygen	103-107	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	149-154
33379337-7	2020	The depletion of Tif51A, but not Tif51B, compromised yeast growth under respiration and reduced oxygen consumption.	Oxygen	96-102	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	17-23
33263395-7	2020	The crystal structure was solved for the Nd3+ analogue and revealed that Nd3+ is centered between two [12-MCGaIIIN(shi)-4] MC rings and bound to eight hydroximate oxygen ions (four from each ring) in a pseudosquare antiprismatic fashion adopting a pseudo-D4h symmetry.	Oxygen	163-169	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	41-44
33263395-7	2020	The crystal structure was solved for the Nd3+ analogue and revealed that Nd3+ is centered between two [12-MCGaIIIN(shi)-4] MC rings and bound to eight hydroximate oxygen ions (four from each ring) in a pseudosquare antiprismatic fashion adopting a pseudo-D4h symmetry.	Oxygen	163-169	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	73-76
32977945-8	2020	Interestingly, we found that Ero1 homologs from human, rice, soybean and Arabidopsis, all have a conserved N-glycosylation site near the inner active site that reduces molecular oxygen and provides the oxidizing equivalents.	Oxygen	178-184	endoplasmic reticulum oxidoreductins 1	Arabidopsis thaliana	29-33
33321986-7	2020	Taken together, the results of this study provide important insights into the function of Erv1 in the mitochondria, suggesting that molecular oxygen is a better substrate than cytochrome c for Erv1 in the yeast mitochondria.	Oxygen	142-148	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	193-197
33188066-9	2020	Applying this technology to GPe PV+ neurons in a mouse model of Parkinson"s disease, we discovered evidence for an upregulation of the oxygen homeostasis maintaining pathway involving Hif2a.	Oxygen	135-141	endothelial PAS domain protein 1	Mus musculus	184-189
32934009-4	2020	The respective prolyl-hydroxylases (DdPhyA and TgPhyA) catalyze prolyl-hydroxylation of S-Phase Kinase Associated Protein 1 (Skp1), a reaction enabling adaptation to different dioxygen availability.	Oxygen	176-184	S-phase kinase associated protein 1	Homo sapiens	88-123
32934009-4	2020	The respective prolyl-hydroxylases (DdPhyA and TgPhyA) catalyze prolyl-hydroxylation of S-Phase Kinase Associated Protein 1 (Skp1), a reaction enabling adaptation to different dioxygen availability.	Oxygen	176-184	S-phase kinase associated protein 1	Homo sapiens	125-129
33054659-1	2020	At the onset of an exercise transition, exponential modeling to calculate a time constant (tau) is the conventional method to analyze pulmonary oxygen uptake (VO2p) kinetics for moderate and heavy exercise.	Oxygen	144-150	microtubule associated protein tau	Homo sapiens	91-94
33080281-8	2020	Cell-based results demonstrated that MET was able to reduce UVB-induced intracellular ROS and NADPH oxidase-dependent superoxide (O2  ) production.	Oxygen	130-132	SAFB like transcription modulator	Homo sapiens	37-40
33261601-6	2020	In particular, silenced CSN8 blocks the EMT and dormancy processes induced by the hypoxia of 1% O2 in vitro and undermines the adaptive capacity of colorectal cancer cells in vivo.	Oxygen	96-98	COP9 signalosome subunit 8	Homo sapiens	24-28
32717463-8	2020	Discriminant analysis of data from 533 published datasets revealed that biochar derived from hardwood (HBC) and softwood generally have greater surface area and carbon content, but lower content of oxygen and mineral constituents, than manure- (MBC) and grass-derived biochars (GBC).	Oxygen	198-204	keratin 88, pseudogene	Homo sapiens	103-106
33147025-1	2020	The intrinsic poor thermal stability of layered LiNixCoyMn1-x-yO2 (NCM) cathodes and the exothermic side reactions triggered by the associated oxygen release are the main safety threats for their large-scale implantation.	Oxygen	143-149	CWC22 spliceosome associated protein homolog	Homo sapiens	67-70
33208731-3	2020	CD39 is regulated via single-nucleotide-polymorphisms and upon activation of aryl-hydrocarbon-receptor and oxygen-mediated pathways.	Oxygen	107-113	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-4
33184378-6	2020	These effects are initiated by ASA/SA-triggered Akt/mTOR/AMPK-dependent activation of nitric oxide synthase 3 (eNOS), which increases nitric oxide and reactive oxygen species production inducing ER stress response.	Oxygen	160-166	mechanistic target of rapamycin kinase	Mus musculus	52-56
33184378-6	2020	These effects are initiated by ASA/SA-triggered Akt/mTOR/AMPK-dependent activation of nitric oxide synthase 3 (eNOS), which increases nitric oxide and reactive oxygen species production inducing ER stress response.	Oxygen	160-166	nitric oxide synthase 3, endothelial cell	Mus musculus	111-115
33240803-0	2020	Tissue Factor-Targeted "O2-Evolving" Nanoparticles for Photodynamic Therapy in Malignant Lymphoma.	Oxygen	24-26	coagulation factor III, tissue factor	Homo sapiens	0-13
22295625-4	2011	The results showed that the oxygen and sulfur heterocyclic aromatic compounds in the surface soils mainly contained dibenzofuran, methyl- and C2-dibenzofuran series, dibenzothiophene, methyl-, C2- and C3-dibenzothiophene series and benzonaphthothiophene series.	Oxygen	28-34	complement C2	Homo sapiens	193-203
21749921-6	2011	Here, we provided the first evidence that an oxygen and glucose deprivation episode can induce, in CA1 hippocampal slices, iLTP by modulation of the NO/cGMP/PKG pathway.	Oxygen	45-51	protein kinase cGMP-dependent 1	Homo sapiens	157-160
22031289-10	2011	This work provides insight into the O(2)-mediated regulation of Nodal, a key stem cell-associated factor, and reveals that Nodal may be a target for the treatment and prevention of hypoxia-induced tumor progression.	Oxygen	36-40	nodal growth differentiation factor	Homo sapiens	64-69
22031289-10	2011	This work provides insight into the O(2)-mediated regulation of Nodal, a key stem cell-associated factor, and reveals that Nodal may be a target for the treatment and prevention of hypoxia-induced tumor progression.	Oxygen	36-40	nodal growth differentiation factor	Homo sapiens	123-128
33240803-3	2020	In this study, we designed a lymphoma tissue factor-targeted "O2-evolving" strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma.	Oxygen	62-64	coagulation factor III, tissue factor	Homo sapiens	38-51
33240803-3	2020	In this study, we designed a lymphoma tissue factor-targeted "O2-evolving" strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma.	Oxygen	62-64	G elongation factor mitochondrial 1	Homo sapiens	140-144
33240803-3	2020	In this study, we designed a lymphoma tissue factor-targeted "O2-evolving" strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma.	Oxygen	254-260	coagulation factor III, tissue factor	Homo sapiens	38-51
22050768-3	2011	Recently, we have identified a beneficial effect of low oxygen availability on the expression of a human Fab fragment in Pichia pastoris.	Oxygen	56-62	FA complementation group B	Homo sapiens	105-108
21915924-2	2011	The participation mechanism is based on intramolecular interaction between the lone electron pair of the oxygen atom of the C-2 ether function and the nitrile molecule when they are positioned in a cis configuration.	Oxygen	105-111	complement C2	Homo sapiens	124-127
21983962-1	2011	PHD2 serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
21983962-1	2011	PHD2 serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage.	Oxygen	110-116	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
21562317-1	2011	Alveolar edema and decreased inspired Po(2) decrease the oxygen supply to alveolar epithelia, impairing beta(2)-adrenergic receptor (beta2AR) signaling and alveolar reabsorption.	Oxygen	57-63	adrenoceptor beta 2	Rattus norvegicus	133-140
33240803-7	2020	These data show that the combined administration of PDT and CENPs can prompt tissue factor-cascade-targeted and self-supply of oxygen and that it has a good therapeutic effect on malignant lymphoma.	Oxygen	127-133	coagulation factor III, tissue factor	Homo sapiens	77-90
22336306-13	2011	CONCLUSIONS: Prolonged exposure of high concentration of oxygen may cause impairment of lung vascular development by inhibiting expression of Ang-1 in neonatal rats, which is likely to contribute to pathogenesis of BPD.	Oxygen	57-63	angiopoietin 1	Rattus norvegicus	142-147
33173134-4	2020	The 13 outlier windows detected by at least two approaches, harboured genes (e.g. GH1, ACE, ASIC3, HSPH1, MVD, BCL2, HIGD2A, CBFA2T3) that may be involved in physiological adaptations required to cope with environmental stressors that are typical of the North African area such as infectious diseases, extended drought periods, scarce food supply, oxygen scarcity in the mountainous areas and high-intensity solar radiation.	Oxygen	348-354	somatotropin	Bos taurus	82-85
21832056-6	2011	In a model of oxygen-induced retinopathy, pathological neovascularization, which results from tissue hypoxia, was also strongly inhibited in angptl4-deficient mice.	Oxygen	14-20	angiopoietin-like 4	Mus musculus	141-148
21982230-5	2011	In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.	Oxygen	45-51	fucosyltransferase 1 (H blood group)	Homo sapiens	105-108
33173134-4	2020	The 13 outlier windows detected by at least two approaches, harboured genes (e.g. GH1, ACE, ASIC3, HSPH1, MVD, BCL2, HIGD2A, CBFA2T3) that may be involved in physiological adaptations required to cope with environmental stressors that are typical of the North African area such as infectious diseases, extended drought periods, scarce food supply, oxygen scarcity in the mountainous areas and high-intensity solar radiation.	Oxygen	348-354	mevalonate diphosphate decarboxylase	Bos taurus	106-109
33311346-1	2020	n. (Nematoda: Desmodoridae) from the oxygen minimum zone of Eastern Arabian Sea margin.	Oxygen	37-43	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
21771264-7	2011	Patients with compared with those without HPS had significantly younger age, albumin levels and saturation of oxygen (SaO(2)) in an erect position, but higher left ventricular end diastolic diameter (LVEDD), ejection fraction, E-wave peak velocity of tricuspid valve, left atrial volume, TDI E wave (early diastolic period) at the right free wall/tricuspid annulus (cm/s) and TDI S wave (systolic) at the left lateral wall/mitral annulus (TDI Smv).	Oxygen	110-116	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	42-45
33311346-3	2020	n. is described from the oxygen minimum zone of the eastern Arabian Sea (216m) margin.	Oxygen	25-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
33147875-6	2020	These compounds, designated MMA, bind to the alpha-globin and/or beta-globin to increase Hb affinity for oxygen and concomitantly inhibit erythrocyte sickling with significantly enhanced and sustained pharmacologic activities in vitro.	Oxygen	105-111	hemoglobin subunit beta	Homo sapiens	65-76
21726645-3	2011	Rather, the obesity in male Mt3-null mice was likely the result of decreased metabolic rates, as indicated by lower oxygen consumption and carbon dioxide production.	Oxygen	116-122	metallothionein 3	Mus musculus	28-31
33136591-2	2020	Gas blender attached to ECMO is used to allow precise adjustment of characteristics of fresh gas flow, that is, blood oxygen delivery and carbon dioxide removal.	Oxygen	118-124	gastrin	Homo sapiens	0-3
21771794-0	2011	Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes.	Oxygen	58-64	nitric oxide associated 1	Mus musculus	0-33
21771794-0	2011	Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes.	Oxygen	58-64	nitric oxide associated 1	Mus musculus	35-39
21771794-3	2011	Here, we focus on mouse nitric oxide-associated protein 1 (mNOA1), which has been identified as an important component of the machinery that adjusts OXPHOS activity to oxygen concentrations.	Oxygen	168-174	nitric oxide associated 1	Mus musculus	24-57
21771794-3	2011	Here, we focus on mouse nitric oxide-associated protein 1 (mNOA1), which has been identified as an important component of the machinery that adjusts OXPHOS activity to oxygen concentrations.	Oxygen	168-174	nitric oxide associated 1	Mus musculus	59-64
21771794-7	2011	mNOA1 is transcriptionally regulated in an oxygen-sensitive manner.	Oxygen	43-49	nitric oxide associated 1	Mus musculus	0-5
21771794-8	2011	We propose that oxygen-dependent regulation of mNOA1 is instrumental to adjusting OXPHOS activity to oxygen availability, thereby controlling mitochondrial metabolism.	Oxygen	16-22	nitric oxide associated 1	Mus musculus	47-52
33136591-2	2020	Gas blender attached to ECMO is used to allow precise adjustment of characteristics of fresh gas flow, that is, blood oxygen delivery and carbon dioxide removal.	Oxygen	118-124	gastrin	Homo sapiens	93-96
21771794-8	2011	We propose that oxygen-dependent regulation of mNOA1 is instrumental to adjusting OXPHOS activity to oxygen availability, thereby controlling mitochondrial metabolism.	Oxygen	101-107	nitric oxide associated 1	Mus musculus	47-52
32433558-5	2020	In contrast, oxygen, and nutrient deprivation promote high amounts of TRAILR2 expression in TRAIL-hypersensitive cells in inner spheroid layers.	Oxygen	13-19	TNF receptor superfamily member 10b	Homo sapiens	70-77
21737783-5	2011	In melanomas and in retinas of mice with oxygen-induced retinopathy, MFG-E8 colocalized with pericytes rather than endothelial cells, and platelet-derived growth factor receptor beta+ pericytes/pericyte precursors purified from tumors contained large amounts of MFG-E8 mRNA.	Oxygen	41-47	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	69-75
21737783-5	2011	In melanomas and in retinas of mice with oxygen-induced retinopathy, MFG-E8 colocalized with pericytes rather than endothelial cells, and platelet-derived growth factor receptor beta+ pericytes/pericyte precursors purified from tumors contained large amounts of MFG-E8 mRNA.	Oxygen	41-47	platelet derived growth factor receptor, beta polypeptide	Mus musculus	138-182
21737783-5	2011	In melanomas and in retinas of mice with oxygen-induced retinopathy, MFG-E8 colocalized with pericytes rather than endothelial cells, and platelet-derived growth factor receptor beta+ pericytes/pericyte precursors purified from tumors contained large amounts of MFG-E8 mRNA.	Oxygen	41-47	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	262-268
32768595-1	2020	BACKGROUND & AIMS: Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the upregulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes survival of cells under low-oxygen conditions.	Oxygen	197-203	hypoxia inducible factor 1, alpha subunit	Mus musculus	112-144
21179001-8	2011	In contrast, AMN+LEP increased heart rate and oxygen consumption above levels in LEP or AMN-treated rats.	Oxygen	46-52	islet amyloid polypeptide	Rattus norvegicus	13-16
21617579-0	2011	beta2-adrenergic receptor antagonist butoxamine partly abolishes the protection of 100% oxygen treatment against zymosan-induced generalized inflammation in mice.	Oxygen	88-94	adrenergic receptor, beta 2	Mus musculus	0-25
21617579-9	2011	We found that pretreatment with beta2AR antagonist butoxamine partly abolished the protection of 100% oxygen inhalation.	Oxygen	102-108	adrenergic receptor, beta 2	Mus musculus	32-39
21617579-12	2011	Thus, 100% oxygen inhalation may protect against zymosan-induced generalized inflammation in mice partly through activation of beta2AR pathway and subsequently enhance cAMP levels in both serum and tissue.	Oxygen	11-17	adrenergic receptor, beta 2	Mus musculus	127-134
21844787-1	2011	Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors hypoxia-inducible factor 1alpha and nuclear factor kappaB (NF-kappaB) via inhibition of oxygen sensing hydroxylase enzymes.	Oxygen	216-222	hypoxia inducible factor 1, alpha subunit	Mus musculus	128-159
32768595-1	2020	BACKGROUND & AIMS: Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the upregulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes survival of cells under low-oxygen conditions.	Oxygen	197-203	hypoxia inducible factor 1, alpha subunit	Mus musculus	146-151
32891637-7	2020	Our data revealed that Beclin1 deficiency exacerbated smoke exposure-induced myocardial anomalies in geometry, fractional shortening, cardiomyocyte function, intracellular Ca2+ handling, TEM ultrastructure, and inflammation along with pronounced apoptosis and O2- production.	Oxygen	260-263	beclin 1, autophagy related	Mus musculus	23-30
21911158-6	2011	We determined that lower than normal, oxygen concentrations in hypoxic environment, reduced ROS generation, induced expansion of more primitive CD34(+)AC133(+)HSCs and active CD34(+) HSCs, maintaining more stem cells in the G(0)/G(1) phase, which is helpful for the growth of pre-colony forming unit (pre-CFUs) and various colonies (BFU-E, CFU-GM, CFU-GEMM).	Oxygen	38-44	CD34 antigen	Mus musculus	175-179
32750410-10	2020	The GHSR prevented a decrease in ambulatory activity and oxygen consumption in UN offspring during ad libitum feeding.	Oxygen	57-63	growth hormone secretagogue receptor	Mus musculus	4-8
22276431-6	2011	The conclusion is made, that the increase of O2(.-) generation in wheat coleoptiles under the action of SaA and SuA is related, probably, to the increase of apoplast peroxidase and NADP.H-oxidase activity, and the rise of H2O2 content is related to the growth of SOD activity.	Oxygen	45-47	peroxidase-like	Triticum aestivum	166-176
32949661-0	2020	OXYGEN EXPOSURE IN EARLY LIFE ACTIVATES NLRP3 INFLAMMASOME IN MOUSE BRAIN.	Oxygen	0-6	NLR family, pyrin domain containing 3	Mus musculus	40-45
32573860-6	2020	In vitro, astrocytes exposed to hypoxia (4% O2 ) for 24 hr exhibited and increase in IL-1beta expression followed by an increase in vascular endothelial growth factor (VEGF) levels.	Oxygen	44-46	interleukin 1 alpha	Mus musculus	85-93
21655578-4	2011	Complex Pt-1 was used for phosphorescent oxygen sensing and the sensitivity (Stern-Volmer quenching constant K(SV) = 0.012 Torr(-1)) is 12-fold of the model complex Pt-2 (K(SV) = 0.001 Torr(-1)).	Oxygen	41-47	zinc finger protein 77	Homo sapiens	8-12
21609781-6	2011	Number of ATM foci was found to be significantly higher in cells exposed to 2Gy oxygen beam.	Oxygen	80-86	ATM serine/threonine kinase	Homo sapiens	10-13
32896707-10	2020	It increased oxygen-dependant hydroxylation and ubiquitination of HIF-1alpha to promote HIF-1alpha degradation.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	66-76
21609781-10	2011	The noteworthy finding of this study is the activation of the sensor proteins, ATM and ATR by oxygen irradiation and the significant activation of Chk1, Chk2 and p53 only in the oxygen beam irradiated cells.	Oxygen	94-100	ATM serine/threonine kinase	Homo sapiens	79-82
21652295-3	2011	We aimed first to evaluate the effect of normobaric, systemic hypoxia (11% O2) on HIF-1alpha and VEGF mRNA levels in the heart muscle; secondly, to compare the levels of HIF-1alpha and VEGF mRNA in the left and right ventricle muscles.	Oxygen	75-77	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	82-92
32896707-10	2020	It increased oxygen-dependant hydroxylation and ubiquitination of HIF-1alpha to promote HIF-1alpha degradation.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-98
32859605-4	2020	Deprivation of glutamine by glutamine-withdrawal, GLS knockdown, or exposure to the GLS inhibitor CB-839 resulted in robust induction of reactive oxygen species in high GLS-expressing but not low GLS-expressing ovarian cancer cells.	Oxygen	146-152	glutaminase	Mus musculus	50-53
21069338-4	2011	SSAT2, a related protein, stabilizes the interaction of the VHL protein and elongin C with HIF-1 leading to oxygen-dependent HIF-1alpha ubiquitination and degradation.	Oxygen	108-114	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	0-5
21656580-4	2011	The influence of the O2-anion substituent correlated negatively with the oxygen charge density in case of galectin-1, -3, and -9N.	Oxygen	21-23	galectin 1	Homo sapiens	106-129
21656580-4	2011	The influence of the O2-anion substituent correlated negatively with the oxygen charge density in case of galectin-1, -3, and -9N.	Oxygen	73-79	galectin 1	Homo sapiens	106-129
32859605-4	2020	Deprivation of glutamine by glutamine-withdrawal, GLS knockdown, or exposure to the GLS inhibitor CB-839 resulted in robust induction of reactive oxygen species in high GLS-expressing but not low GLS-expressing ovarian cancer cells.	Oxygen	146-152	glutaminase	Mus musculus	84-87
32859605-4	2020	Deprivation of glutamine by glutamine-withdrawal, GLS knockdown, or exposure to the GLS inhibitor CB-839 resulted in robust induction of reactive oxygen species in high GLS-expressing but not low GLS-expressing ovarian cancer cells.	Oxygen	146-152	glutaminase	Mus musculus	84-87
32859605-4	2020	Deprivation of glutamine by glutamine-withdrawal, GLS knockdown, or exposure to the GLS inhibitor CB-839 resulted in robust induction of reactive oxygen species in high GLS-expressing but not low GLS-expressing ovarian cancer cells.	Oxygen	146-152	glutaminase	Mus musculus	84-87
21515660-8	2011	Overnight (24 h) exposure of ASM cells to 50% oxygen increased BDNF and TrkB expression and potentiated both SP- and BDNF-induced enhancement of [Ca(2+)](i) (P &lt; 0.05).	Oxygen	46-52	H19 imprinted maternally expressed transcript	Homo sapiens	29-32
21784733-1	2011	BACKGROUND: Recently we have shown that the matricellular CCN3 protein expressed in invasive extravillous trophoblast cells (EVTs) is decreased in early-onset pre-eclampsia and is regulated by oxygen tension.	Oxygen	193-199	cellular communication network factor 3	Homo sapiens	58-62
32938724-2	2020	Because of the hypoxic nature of solid tumors, we investigated if oxygen, via hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha, regulates TEM function in the hypoxic tumor microenvironment.	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
21265612-4	2011	Culturing ASC in a hypoxic incubator (2% oxygen tension) increased the proliferation and migration, and this was mediated by Akt and ERK pathways.	Oxygen	41-47	EPH receptor B2	Homo sapiens	133-136
21933626-8	2011	RESULTS: Compared with control group, blood pH, partial pressure of arterial oxygen to fraction of inspired oxygen ratio, partial pressure of arterial carbon dioxide, and mean pulmonary arterial pressure in LPD group were improved (P &lt; 0.05 or 0.01).	Oxygen	77-83	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	207-210
21933626-8	2011	RESULTS: Compared with control group, blood pH, partial pressure of arterial oxygen to fraction of inspired oxygen ratio, partial pressure of arterial carbon dioxide, and mean pulmonary arterial pressure in LPD group were improved (P &lt; 0.05 or 0.01).	Oxygen	108-114	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	207-210
21610214-4	2011	The Schizosaccharomyces pombe orthologs of Tpa1 and Ett1, Ofd1, and its partner Nro1, respectively, have been shown to regulate the stability of the Sre1 transcription factor in response to oxygen levels.	Oxygen	190-196	oxidative DNA demethylase	Saccharomyces cerevisiae S288C	43-47
21536681-8	2011	Consistent with these findings, hypoxia induced cPLA(2) phosphorylation and activity in VEGF-Src-PLD1-PKCgamma-dependent manner in a mouse model of oxygen-induced retinopathy.	Oxygen	148-154	Rous sarcoma oncogene	Mus musculus	93-96
21536681-8	2011	Consistent with these findings, hypoxia induced cPLA(2) phosphorylation and activity in VEGF-Src-PLD1-PKCgamma-dependent manner in a mouse model of oxygen-induced retinopathy.	Oxygen	148-154	protein kinase C, gamma	Mus musculus	102-110
21788340-0	2011	Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.	Oxygen	94-100	annexin A2	Mus musculus	34-44
21788340-4	2011	Adenoviral-mediated restoration of A2 expression restores neovascularization in the oxygen-primed Anxa2(-/-) retina and reinstates plasmin generation and directed migration in cultured Anxa2(-/-) endothelial cells.	Oxygen	84-90	annexin A2	Mus musculus	98-103
32938724-2	2020	Because of the hypoxic nature of solid tumors, we investigated if oxygen, via hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha, regulates TEM function in the hypoxic tumor microenvironment.	Oxygen	66-72	endothelial PAS domain protein 1	Mus musculus	133-143
33057338-7	2020	Mechanically, Clbn mediates mitochondrial dynamics in ECs and removal of clbn leads to mitochondrial fragmentation, accumulation of reactive oxygen species, ECs damage, activation of JNK and JAK-STAT signaling pathways.	Oxygen	141-147	Caliban	Drosophila melanogaster	14-18
21499920-7	2011	Oxygen-induced defective vascular development correlated with a dramatic decrease in soluble guanylyl cyclase, phosphodiesterase (Pde) 4B and Pde4C mRNAs.	Oxygen	0-6	phosphodiesterase 4C, cAMP specific	Mus musculus	142-147
21498671-3	2011	Genetic and pharmacologic inhibition of Dll4/Notch prevented retinal capillary regression in the oxygen-induced retinopathy (OIR) model and during normal development.	Oxygen	97-103	delta like canonical Notch ligand 4	Homo sapiens	40-44
21498508-2	2011	Erythropoietin, a kidney-derived hormone, and iron are critical for the production of oxygen-carrying mature RBCs.	Oxygen	86-92	erythropoietin	Mus musculus	0-14
33057338-7	2020	Mechanically, Clbn mediates mitochondrial dynamics in ECs and removal of clbn leads to mitochondrial fragmentation, accumulation of reactive oxygen species, ECs damage, activation of JNK and JAK-STAT signaling pathways.	Oxygen	141-147	Caliban	Drosophila melanogaster	73-77
33057412-0	2020	Correction: Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis.	Oxygen	76-82	ferritin heavy chain 1	Homo sapiens	12-32
32852194-4	2020	This decrease is attributed to the combined effects of oxygen vacancy formation and interfacial charge transfer which lead to magnetically active Co2+ ions with ionic radii larger than the Co3+/Co4+ ions typically found in bulk LSCO or single layer films.	Oxygen	55-61	complement C2	Homo sapiens	146-149
20177947-3	2011	The redox-sensing cysteine residues and the disulfide bond formed between these cysteine residues serve as redox-sensing molecular switches; these switches sense cellular oxidizing factors such as oxygen, reactive oxygen species, and cellular reducing factors such as thioredoxin (Trx), glutathione (GSH), and their family molecules.	Oxygen	197-203	thioredoxin	Homo sapiens	268-279
33009389-5	2020	PQM-1 promotes hypoxic fat metabolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis.	Oxygen	109-115	Delta(9)-fatty-acid desaturase fat-7	Caenorhabditis elegans	99-104
21453436-0	2011	P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.	Oxygen	117-123	carbonic anhydrase 1	Rattus norvegicus	155-158
32773682-12	2020	The mortality of heterozygous ND23 flies exposed to isoflurane in 75% oxygen increased with age, resulting in 54.0 +- 19.6% (n = 4) mortality at 33 to 39 days old, and the percent mortality varied in different genetic backgrounds.	Oxygen	70-76	NADH dehydrogenase (ubiquinone) 23 kDa subunit	Drosophila melanogaster	30-34
21680038-7	2011	Exogenous DSBs form discrete IR-induced foci whereas oxygen stress induced non-localized 53BP1(Ser25) activation.	Oxygen	53-59	tumor protein p53 binding protein 1	Homo sapiens	89-94
21596468-9	2011	The maximal oxygen consumption increased by 3 and 5 mL/kg/min in the EG1 and EG2, respectively.	Oxygen	12-18	mediator complex subunit 28	Homo sapiens	69-72
32570077-1	2020	A gas-pressurized (GP) torrefaction method, proposed in our resent work, can significantly promote the upgrading and oxygen removal of biomass wastes, compared to the traditional torrefaction (AP).	Oxygen	117-123	gastrin	Homo sapiens	2-5
21454678-0	2011	Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9.	Oxygen	56-62	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	110-116
32897801-0	2020	Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133.	Oxygen	44-50	methionine adenosyltransferase 2B	Rattus norvegicus	26-35
21614094-6	2011	Indeed, according to the cell line, the severity and the duration of hypoxia, oxygen deficiency influences very differently p53 protein level and activity.	Oxygen	78-84	transformation related protein 53, pseudogene	Mus musculus	124-127
32723595-3	2020	We tested the angiogenic and arteriogenic efficacy and safety of a baculovirus (BV) encoding mutant, oxygen-resistant hypoxia-inducible factor 1-alpha (mHIF-1alpha), in rabbits with PAD.	Oxygen	101-107	hypoxia inducible factor 1, alpha subunit	Mus musculus	152-163
21491957-2	2011	sGC is a heterodimeric hemoprotein that contains a Heme-Nitric oxide and OXygen binding (H-NOX) domain, a Per/ARNT/Sim (PAS) domain, a coiled-coil (CC) domain, and a catalytic domain.	Oxygen	73-79	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	0-3
32808810-8	2020	Moreover, the half-life of Cx46 S50P was longer than that of Cx46 WT, Cx46 S50P protein was also localized to the endoplasmic reticulum and induced more reactive oxygen species compared to Cx46 WT, which may lead to dysregulation of Cx46-formed gap junction.	Oxygen	162-168	gap junction protein alpha 3	Homo sapiens	27-31
21491957-6	2011	The rat-worm chimera containing the atypical sGC Gcy-33 H-NOX domain was weakly activated by NO, CO, and O(2), suggesting that atypical guanylate cyclases and NO-sensitive guanylate cyclases have a common molecular mechanism for enzyme activation.	Oxygen	105-109	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	45-48
21589870-3	2011	Herein, by decreasing ambient oxygen exposure, we report a ~50% increase in the median tumor-free survival time of p53-/- mice.	Oxygen	30-36	transformation related protein 53, pseudogene	Mus musculus	115-118
21589870-4	2011	In the thymus, reducing oxygen exposure decreased the levels of oxidative DNA damage and RAG recombinase, both of which are known to promote lymphomagenesis in p53-/- mice.	Oxygen	24-30	transformation related protein 53, pseudogene	Mus musculus	160-163
21239537-1	2011	Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor that functions as a master regulator of oxygen homeostasis, has been implicated in fibrinogenesis.	Oxygen	109-115	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
21239537-1	2011	Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor that functions as a master regulator of oxygen homeostasis, has been implicated in fibrinogenesis.	Oxygen	109-115	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
32519270-2	2020	In the present study, we found a dominant upregulation of KCNQ1OT1 both in the plasma of cerebral ischemia patients and in an oxygen-glucose deprivation and reperfusion (OGD/R) model in PC12 cells.	Oxygen	126-132	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	58-66
21318295-7	2011	We conclude that increased cardiac oxygen utilisation, and thereby decreased cardiac efficiency, occurs in non-genetic obesity, which is associated with increased mitochondrial uncoupling due to elevated UCP3 and MTE-1 levels.	Oxygen	35-41	uncoupling protein 3	Rattus norvegicus	204-208
32115713-10	2020	In vivo experiments further revealed that IL-1beta production was increased in LPS-primed mice exposed to hypoxia (9.5% O2 ), which was prevented by a deficiency of NLRP3, an apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1.	Oxygen	120-122	interleukin 1 alpha	Mus musculus	42-50
21436457-3	2011	In this study, we show that inhibition of the oxygen sensor PHD2 in tumor cells stimulates vessel formation but paradoxically results in a profound reduction of tumor growth.	Oxygen	46-52	egl-9 family hypoxia-inducible factor 1	Mus musculus	60-64
32115713-10	2020	In vivo experiments further revealed that IL-1beta production was increased in LPS-primed mice exposed to hypoxia (9.5% O2 ), which was prevented by a deficiency of NLRP3, an apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1.	Oxygen	120-122	NLR family, pyrin domain containing 3	Mus musculus	165-170
32912499-0	2020	Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose-Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis.	Oxygen	34-40	KCNQ1 overlapping transcript 1	Mus musculus	16-24
21553396-6	2011	For reduction of the endogenous aldehyde 4-HNE, the substrate was incubated with CYP in the presence of oxygen and NADPH, and the metabolites were separated by HPLC, using an adaptation of the method by Srivastava et al.	Oxygen	104-110	peptidylprolyl isomerase G	Homo sapiens	81-84
32886483-4	2020	It displays a reversible capacity of 487 mAh g-1, a high value due to a reversible three-electron reaction using Co2+/Co3+, Co3+/Co4+, and O2-/O22- redox, occurring without O2 gas evolution.	Oxygen	139-141	complement C2	Homo sapiens	113-116
21422382-10	2011	Leptin increased oxygen consumption in LepR(flox/flox)/POMC-Cre and wild-type mice.	Oxygen	17-23	leptin receptor	Mus musculus	39-43
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Oxygen	86-90	aquaporin-1	Oryctolagus cuniculus	0-11
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Oxygen	86-90	aquaporin-1	Oryctolagus cuniculus	13-18
32886483-4	2020	It displays a reversible capacity of 487 mAh g-1, a high value due to a reversible three-electron reaction using Co2+/Co3+, Co3+/Co4+, and O2-/O22- redox, occurring without O2 gas evolution.	Oxygen	139-141	complement C4A (Rodgers blood group)	Homo sapiens	129-132
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Oxygen	169-173	aquaporin-1	Oryctolagus cuniculus	0-11
21451971-3	2011	Aquaporin-1 (AQP-1) is a transmembrane channel protein that is permeable to water and O(2), which prevents rapid volume deformation under osmotic stress and facilitates O(2) diffusion across the plasma membrane.	Oxygen	169-173	aquaporin-1	Oryctolagus cuniculus	13-18
21451971-7	2011	AQP-1 was downregulated under hypo-osmotic stress to prevent rapid swelling deformation and was upregulated under hypoxic stress to facilitate O(2) utilization.	Oxygen	143-147	aquaporin-1	Oryctolagus cuniculus	0-5
32886483-4	2020	It displays a reversible capacity of 487 mAh g-1, a high value due to a reversible three-electron reaction using Co2+/Co3+, Co3+/Co4+, and O2-/O22- redox, occurring without O2 gas evolution.	Oxygen	143-145	complement C2	Homo sapiens	113-116
33007859-6	2020	The model was used to investigate the experimental findings that reactive oxygen species induce the total activation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR).	Oxygen	74-80	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	120-177
21345458-5	2011	Regressions between environmental parameters and VLP abundance uncovered negative correlations between salinity and viral abundance during one, and dissolved oxygen and viral abundance during the second voyage.	Oxygen	158-164	VHL like	Homo sapiens	49-52
33007859-6	2020	The model was used to investigate the experimental findings that reactive oxygen species induce the total activation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR).	Oxygen	74-80	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	179-184
33072004-3	2020	We investigated the effects of the first two enzymatic steps in the dissimilatory sulfate reduction (DSR) network - sulfate permease and sulfate adenylyl transferase (Sat) - on the sulfur and oxygen isotopic composition of residual sulfate.	Oxygen	192-198	sat	Desulfovibrio vulgaris str. Hildenborough	167-170
21074893-5	2011	A possible explanation could be the induction of an O2- burst at non-toxic levels, which could drive directly or indirectly several processes associated with root elongation in 25, 50 and 75 mug mL-1 OGA-treated seedlings.	Oxygen	52-54	L1 cell adhesion molecule	Mus musculus	195-199
21074893-6	2011	Analyses using confocal microscopy showed that the increase in the O2- generation, mainly in the epidermal cells, induced by 50 mug mL-1 OGA could be related to the promoting effect on root growth.	Oxygen	67-69	L1 cell adhesion molecule	Mus musculus	132-136
21635242-1	2011	PURPOSE: Patients with juvenile myoclonic epilepsy (JME) show evidence of microstructural white matter (WM) damage of thalamocortical fiber tracts and changes of blood oxygen level dependent (BOLD) signal in a striatothalamocortical network.	Oxygen	168-174	myoclonic epilepsy, juvenile, 2	Homo sapiens	52-55
32936168-1	2020	Oxygen migration and spectroscopic properties of coronene (C24) epoxides and persulfurated coronene (PSC) oxides have been investigated by using density functional theory (DFT) and time-dependent density functional theory (TD-DFT).	Oxygen	0-6	l(1)1Ef	Drosophila melanogaster	59-62
21949641-3	2011	Here, we show that in C. elegans the Wnt ligand, LIN-44, and its Frizzled receptor, LIN-17, regulate dendrite development of the PQR oxygen sensory neuron.	Oxygen	133-139	Frizzled-4	Caenorhabditis elegans	84-90
21911158-6	2011	We determined that lower than normal, oxygen concentrations in hypoxic environment, reduced ROS generation, induced expansion of more primitive CD34(+)AC133(+)HSCs and active CD34(+) HSCs, maintaining more stem cells in the G(0)/G(1) phase, which is helpful for the growth of pre-colony forming unit (pre-CFUs) and various colonies (BFU-E, CFU-GM, CFU-GEMM).	Oxygen	38-44	CD34 antigen	Mus musculus	144-148
21849555-2	2011	It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia, oxygen/glucose deprivation (OGD), leads to an enhanced permeability of AMPARs to Ca(2+), resulting in delayed cell death.	Oxygen	117-123	carbonic anhydrase 1	Rattus norvegicus	67-70
21609760-9	2011	Oxygen consumption and alpha-dicarbonyl yield were shown to be dependent on AA or MAA concentrations (1-50 mM) and on H(2)O(2) or tert-butOOH added to the Mb-containing reaction mixtures.	Oxygen	0-6	myoglobin	Homo sapiens	155-157
21417287-5	2011	Overall, we observe that the greatest loss in facioselectivity for glycals and 4-DPs is caused by removal of the C3 oxygen, followed by the C5/anomeric substituent, and least of all by the C4/C2 oxygen.	Oxygen	195-201	complement C4A (Rodgers blood group)	Homo sapiens	189-194
21435441-4	2011	Administration of IGFBP-3 plasmid to mouse pups that underwent the oxygen-induced retinopathy model resulted in increased pericyte ensheathment and reduced pericyte apoptosis in the developing retina.	Oxygen	67-73	insulin-like growth factor binding protein 3	Mus musculus	18-25
21435441-5	2011	Increased IGFBP-3 expression reduced the number of activated microglial cells and decreased apoptosis of neuronal cells in the oxygen-induced retinopathy model.	Oxygen	127-133	insulin-like growth factor binding protein 3	Mus musculus	10-17
20701429-5	2011	Exaggerated Ca(2+) signaling through InsP(3)R-PS interaction is a disease specific and robust proximal mechanism in AD that may contribute to the pathology of AD by enhanced generation of reactive oxygen species.	Oxygen	197-203	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	37-45
32936168-3	2020	The predicted electronic absorptions and emissions of the C24 epoxides strongly depend on the location of oxygen.	Oxygen	106-112	l(1)1Ef	Drosophila melanogaster	58-61
32930093-3	2020	Here, we show that SWELL1 (Lrrc8a) functionally encodes a swell-activated anion channel that regulates PI3K-AKT, ERK1/2, mTOR signaling, muscle differentiation, myoblast fusion, cellular oxygen consumption, and glycolysis in skeletal muscle cells.	Oxygen	187-193	leucine rich repeat containing 8A VRAC subunit A	Mus musculus	27-33
21362406-0	2011	Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.	Oxygen	10-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	185-191
21576378-1	2011	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a critical transcription factor that controls oxygen homeostasis in response to hypoxia, inflammation, and oxidative stress.	Oxygen	94-100	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
21576378-1	2011	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a critical transcription factor that controls oxygen homeostasis in response to hypoxia, inflammation, and oxidative stress.	Oxygen	94-100	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
31954830-5	2020	Similarly, the levels of the NLRP1 inflammasome proteins, cleaved caspase-1, mature IL-1beta and IL-18 were elevated in SY-5Y cells exposed to oxygen-glucose deprivation (OGD).	Oxygen	143-157	interleukin 1 alpha	Homo sapiens	84-92
21806148-3	2011	The maximum depth of the shoulder well is chosen so that the resulting potential reproduces the oxygen-oxygen radial distribution function of the ST4 model of water.	Oxygen	96-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	146-149
21806148-3	2011	The maximum depth of the shoulder well is chosen so that the resulting potential reproduces the oxygen-oxygen radial distribution function of the ST4 model of water.	Oxygen	103-109	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	146-149
21385841-5	2011	Our data reveal that depletion of PINK1 induces moderate fragmentation of the mitochondrial network, mitochondrial membrane depolarization and increased production of reactive oxygen species.	Oxygen	176-182	PTEN induced putative kinase 1	Mus musculus	34-39
32929120-5	2020	Ectopic overexpression of UQCRH in KMRC2 restored mitochondrial membrane potential, increased oxygen consumption, and attenuated the Warburg effect at the cellular level.	Oxygen	94-100	ubiquinol-cytochrome c reductase hinge protein	Homo sapiens	26-31
20977891-7	2011	Taken together our results show that the Cdk5/p35 complex may significantly contribute to modulation of Hif-1alpha stabilisation and impact neuronal survival during oxygen deprivation.	Oxygen	165-171	cyclin dependent kinase 5	Homo sapiens	41-45
20813992-7	2011	(1) Alveolar hypoxia (10% O(2) breathing, 60 minutes) produced a rapid (5-minute) increase in plasma MCP-1 concentrations in conscious intact rats but not in alveolar macrophage-depleted rats.	Oxygen	26-30	C-C motif chemokine ligand 2	Rattus norvegicus	101-106
32806001-5	2020	The presence of bismuth and oxygen vacancies enhances the thermal stability of the Bi1.5Ti2O6.25 phase in comparison with the Bi2Ti2O7 phase.	Oxygen	28-34	transmembrane BAX inhibitor motif containing 6	Homo sapiens	83-86
21555366-0	2011	Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.	Oxygen	100-106	AKT serine/threonine kinase 2	Homo sapiens	0-4
21555366-0	2011	Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.	Oxygen	100-106	microRNA 21	Homo sapiens	88-94
21555366-4	2011	By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms.	Oxygen	28-34	microRNA 21	Homo sapiens	16-22
21555366-4	2011	By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms.	Oxygen	28-34	AKT serine/threonine kinase 2	Homo sapiens	48-52
21247092-0	2011	Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and alpha-N-acetylglucosaminyltransferase enzymes involved in O2 signaling in dictyostelium.	Oxygen	136-138	S-phase kinase associated protein 1	Homo sapiens	17-21
21193583-2	2011	We have previously obtained evidence of the involvement of cytochrome P-450, possibly of the 3A subfamily (CYP3A), in oxygen sensing and have also identified endothelin (ET)-1 as the attendant effector for the contraction.	Oxygen	118-124	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	59-75
21555366-4	2011	By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms.	Oxygen	28-34	phosphatase and tensin homolog	Homo sapiens	67-71
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Oxygen	17-19	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	177-184
21644573-4	2011	In an MRC, high overpotentials are avoided through oxidation of organic matter by exoelectrogenic bacteria on the anode and oxygen reduction on the cathode.	Oxygen	124-130	CD200 molecule	Homo sapiens	6-9
21279630-3	2011	Among these, it was found that insertion of oxygen atoms occurred at histidine for HG and HGG, and both histidine and glycine for GH, GHG, and GGH.	Oxygen	44-50	gamma-glutamyl hydrolase	Homo sapiens	143-146
21156216-9	2011	Our overall results indicate that EC-SOD is expressed spatiotemporally in developing embryos and surrounding extraembryonic tissues during mouse organogenesis, thus suggesting that EC-SOD may be relevant to organogenesis, playing the role of an antioxidant enzyme against endogenous and exogenous oxygen stresses.	Oxygen	297-303	superoxide dismutase 3, extracellular	Mus musculus	34-40
21156216-9	2011	Our overall results indicate that EC-SOD is expressed spatiotemporally in developing embryos and surrounding extraembryonic tissues during mouse organogenesis, thus suggesting that EC-SOD may be relevant to organogenesis, playing the role of an antioxidant enzyme against endogenous and exogenous oxygen stresses.	Oxygen	297-303	superoxide dismutase 3, extracellular	Mus musculus	181-187
21084309-3	2011	The C298S mutant of hAR reproduces many characteristics of activated hAR, although it differs from wild-type hAR only by the replacement of a single sulfur atom with oxygen.	Oxygen	166-172	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	20-23
21158588-0	2011	Expression profile and regulation of telomerase reverse transcriptase on oxygen-induced retinal neovascularization.	Oxygen	73-79	telomerase reverse transcriptase	Mus musculus	37-69
21280111-1	2011	Amyloid beta25-35 (Abeta) peptide may be neurotoxic during the progression of Alzheimer"s disease by eliciting reactive oxygen species.	Oxygen	120-126	amyloid beta (A4) precursor protein	Mus musculus	19-24
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Oxygen	17-19	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	186-258
21158588-2	2011	In this study, we investigated the expression profiles of telomerase reverse transcriptase (Tert) in a mouse model of oxygen-induced retinal neovascularization and explored the possibility of inhibiting a retinal Tert expression with small interfering RNAs (SiRNA) as a novel potential approach to suppress proliferative retinopathy.	Oxygen	118-124	telomerase reverse transcriptase	Mus musculus	92-96
21158588-6	2011	RESULTS: Retinal Tert expression, as assessed by both mRNA and protein levels, was significantly up-regulated during the proliferative phase of oxygen-induced retinal neovascularization.	Oxygen	144-150	telomerase reverse transcriptase	Mus musculus	17-21
21158588-8	2011	CONCLUSIONS: The expression of Tert was up-regulated during the development of oxygen-induced retinal neovascularization.	Oxygen	79-85	telomerase reverse transcriptase	Mus musculus	31-35
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Oxygen	85-87	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	177-184
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Oxygen	16-22	euchromatic histone lysine methyltransferase 1	Homo sapiens	119-135
21290250-10	2011	Moreover, cultivation of BeWo cells under low oxygen conditions impaired intercellular fusion and upregulated fibulin-5 expression.	Oxygen	46-52	fibulin 5	Homo sapiens	110-119
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Oxygen	16-22	euchromatic histone lysine methyltransferase 1	Homo sapiens	137-140
33088284-7	2020	In this manner, the methyltransferase activity of G9a and GLP are hypoxia-inducible and thus present a new avenue of low-oxygen signaling.	Oxygen	121-127	euchromatic histone lysine methyltransferase 1	Homo sapiens	58-61
33088284-9	2020	In this article we aim to review the effects of oxygen on G9a and GLP function, non-histone methylation events inflicted by these methyltransferases, and the clinical relevance of these enzymes in cancer.	Oxygen	48-54	euchromatic histone lysine methyltransferase 1	Homo sapiens	66-69
21071708-9	2011	Our results also suggest that HKII may be important for the remodeling of the viable cardiac tissue because its modulation in vitro alters cellular energy levels, O2 consumption, and contractility.	Oxygen	163-165	hexokinase 2	Mus musculus	30-34
31729644-2	2020	Reactive oxygen species modulator 1 (ROMO1) and the overlapping with the M-AAA protease 1 homolog (OMA1) proteins are the most important mitochondrial membrane proteins, which are involved in modulating reactive oxygen species (ROS) production and the regulation of mitochondrial structure dynamics.	Oxygen	9-15	OMA1 zinc metallopeptidase	Homo sapiens	99-103
21322487-4	2011	The Fe-O2 and the O-O stretching frequencies of the IDO-Trp-O2 ternary complex at Trp concentrations of 50 microM and 8 mM are essentially identical.	Oxygen	18-21	indoleamine 2,3-dioxygenase 1	Homo sapiens	52-55
31729644-2	2020	Reactive oxygen species modulator 1 (ROMO1) and the overlapping with the M-AAA protease 1 homolog (OMA1) proteins are the most important mitochondrial membrane proteins, which are involved in modulating reactive oxygen species (ROS) production and the regulation of mitochondrial structure dynamics.	Oxygen	212-218	OMA1 zinc metallopeptidase	Homo sapiens	99-103
32727891-5	2020	Intestinal I/R injury caused acute lung injury (ALI) characterized by inflammation, reactive oxygen species generation, and vascular permeability, which was markedly improved by NLRP3 deficiency.	Oxygen	93-99	NLR family, pyrin domain containing 3	Mus musculus	178-183
21870521-2	2011	The intracellular distribution of oxygen consumption rates, pO2, NO and myoglobin was calculated by mathematical modeling of diffusion reactions of O2, NO and myoglobin in the muscle cell.	Oxygen	34-40	myoglobin	Homo sapiens	159-168
21870521-6	2011	Myoglobin not only contributes to tissue O2 supply, but it can locally affect the NO concentration.	Oxygen	41-43	myoglobin	Homo sapiens	0-9
21870521-7	2011	Acting as an NO scavenger under normoxia and as an NO producer under hypoxia, myoglobin together with NO can provide fine adjustment of muscle oxygen regimen via an increase in tissue pO, and elimination a mismatch between oxygen supply and demand.	Oxygen	143-149	myoglobin	Homo sapiens	78-87
21870521-7	2011	Acting as an NO scavenger under normoxia and as an NO producer under hypoxia, myoglobin together with NO can provide fine adjustment of muscle oxygen regimen via an increase in tissue pO, and elimination a mismatch between oxygen supply and demand.	Oxygen	223-229	myoglobin	Homo sapiens	78-87
32854434-2	2020	Although induced-heme oxygenase-1 (HO-1) has been found to protect cells against oxygen radical damage, little information is available regarding the use of bioactive compounds from natural sources for regulating the HO-1 pathway to treat OA.	Oxygen	22-28	heme oxygenase 1	Homo sapiens	35-39
21156009-4	2011	oxy-5 showed an increased sensitivity to oxygen and decreased longevity.	Oxygen	41-47	Uncharacterized protein	Caenorhabditis elegans	0-5
21156009-7	2011	The OXY-5 protein was highly expressed in the neurons, pharynx, and intestine, and expression of oxy-5 from the pan-neuronal H20 promoter efficiently suppressed the increased sensitivity to oxygen in oxy-5.	Oxygen	190-196	Uncharacterized protein	Caenorhabditis elegans	4-9
21156009-7	2011	The OXY-5 protein was highly expressed in the neurons, pharynx, and intestine, and expression of oxy-5 from the pan-neuronal H20 promoter efficiently suppressed the increased sensitivity to oxygen in oxy-5.	Oxygen	190-196	Uncharacterized protein	Caenorhabditis elegans	97-102
21156009-7	2011	The OXY-5 protein was highly expressed in the neurons, pharynx, and intestine, and expression of oxy-5 from the pan-neuronal H20 promoter efficiently suppressed the increased sensitivity to oxygen in oxy-5.	Oxygen	190-196	Uncharacterized protein	Caenorhabditis elegans	200-205
21156009-8	2011	These findings suggested that oxy-5 played an important role in the regulation of the sensitivity to oxygen in neuronal cells in C. elegans.	Oxygen	101-107	Uncharacterized protein	Caenorhabditis elegans	30-35
22553602-1	2011	AIM: To investigate the expression of FLT4 in retina with oxygen induced retinopathy (OIR) and in brain endothelial cell lines (bEnd3) under hypoxia conditions in mice.	Oxygen	58-64	FMS-like tyrosine kinase 4	Mus musculus	38-42
20887729-9	2011	Being a highly conserved pathway and linked to IIS/TOR, the hypoxia gene expression pattern seen in honey bee larvae denotes that the hypoxia pathway has undergone a transformation, at least during larval development, from a response to environmental oxygen concentrations to an endogenous regulatory factor in the diphenic development of honey bee larvae.	Oxygen	251-257	serine/threonine-protein kinase mTOR	Apis mellifera	51-54
32984222-7	2020	Smooth muscle cells of the ductus can sense oxygen through a mitochondrial network by the role of Rho-kinase pathway which ends up with increased intracellular calcium levels and contraction of myosin light chains.	Oxygen	44-50	myosin heavy chain 14	Homo sapiens	194-200
31668121-8	2020	Propranolol specifically induced reactive oxygen species production, which was critical for IL23A secretion, in Langerhans-like cells.	Oxygen	42-48	interleukin 23 subunit alpha	Homo sapiens	92-97
20817094-7	2011	H(2)O(2) production rate by PINK1(-/-) mitochondria was lower than PINK1(+/+) mitochondria as a consequence of decreased oxygen consumption rate, while the proportion (H(2)O(2) production rate per oxygen consumption rate) was higher.	Oxygen	121-127	PTEN induced putative kinase 1	Mus musculus	28-33
20817094-7	2011	H(2)O(2) production rate by PINK1(-/-) mitochondria was lower than PINK1(+/+) mitochondria as a consequence of decreased oxygen consumption rate, while the proportion (H(2)O(2) production rate per oxygen consumption rate) was higher.	Oxygen	197-203	PTEN induced putative kinase 1	Mus musculus	28-33
21980427-1	2011	BACKGROUND: Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells.	Oxygen	117-123	transketolase like 1	Homo sapiens	12-32
21980427-1	2011	BACKGROUND: Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells.	Oxygen	117-123	transketolase like 1	Homo sapiens	34-39
32557799-6	2020	These cells exhibited an increased O2 consumption rate, due to IGF2 upregulation.	Oxygen	35-37	insulin-like growth factor 2	Mus musculus	63-67
32289203-4	2020	The adsorbed CO on Ir1 reacts with the adjacent O atom to produce CO2, yielding an oxygen vacancy (Ovac).	Oxygen	83-89	nischarin	Homo sapiens	19-22
21765940-4	2011	However, HELZ proteolytic regulation was found to be oxygen-independent, supporting the notion that a LxxLAP sequence motif alone is not sufficient for oxygen-dependent protein destruction.	Oxygen	53-59	helicase with zinc finger	Homo sapiens	9-13
32608404-1	2020	The gas-phase vibrational spectra of reactive (H2 and O2) and inert gases (N2 and Ar) have been studied by near-ambient pressure (NAP) ultraviolet photoelectron spectroscopy (NAPUPS) up to 0.3 mbar pressure.	Oxygen	54-56	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-7
21677770-10	2011	The proangiogenic cytokines secreted by CD34+/M-cad+ cells induced oxygen- and nutrient-depleted endothelial cell sprouting significantly better than CD34+/M-cad- cells during hypoxia.	Oxygen	67-73	CD34 antigen	Mus musculus	40-44
32360749-3	2020	Not surprisingly, the reduction of ferric myoglobin to ferrous myoglobin under aerobic conditions results in the generation of oxymyoglobin (dioxygen bound ferrous myoglobin).	Oxygen	141-149	myoglobin	Homo sapiens	42-51
21922852-12	2011	Alveolar arterial oxygen gradient is the most valuable negative and positive diagnostic predictor for presence of HPS in cirrhotic patients.	Oxygen	18-24	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	114-117
32360749-3	2020	Not surprisingly, the reduction of ferric myoglobin to ferrous myoglobin under aerobic conditions results in the generation of oxymyoglobin (dioxygen bound ferrous myoglobin).	Oxygen	141-149	myoglobin	Homo sapiens	63-72
20962028-3	2010	HIF-1alpha and HIF-2alpha undergo oxygen-dependent regulation, and their overexpression is frequently associated with metastasis and poor clinical outcomes.	Oxygen	34-40	endothelial PAS domain protein 1	Homo sapiens	15-25
32360749-3	2020	Not surprisingly, the reduction of ferric myoglobin to ferrous myoglobin under aerobic conditions results in the generation of oxymyoglobin (dioxygen bound ferrous myoglobin).	Oxygen	141-149	myoglobin	Homo sapiens	63-72
20980433-0	2010	Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose.	Oxygen	100-106	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
32502935-3	2020	Mass spectrometry demonstrated that hypoxia (1% O2) or rapamycin increased IGFBP-1 phosphorylation singly at Ser101/119/169 (confirmed using immunoblotting) and dually at pSer169 + 174.	Oxygen	48-50	insulin like growth factor binding protein 1	Homo sapiens	75-82
20980433-4	2010	Here, we show that c-MYC protein levels in cancer cells are strikingly reduced in the area distant from the blood vessels in vivo and also under oxygen- and glucose-deprived conditions in vitro.	Oxygen	145-151	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-24
20980433-5	2010	The rapid reduction of c-MYC protein levels requires low levels of both oxygen and glucose, and under these conditions, downregulation is mainly achieved by enhanced degradation.	Oxygen	72-78	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	23-28
20980433-6	2010	Suppression of c-MYC protein levels by small hairpin RNA decreases the necrotic cell death induced by oxygen and glucose deprivation.	Oxygen	102-108	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-20
32502935-7	2020	Changes in IGFBP-1 phosphorylation regulated by mTOR/AAR signaling and CK2 may represent a novel mechanism linking oxygen and nutrient availability to IGF-1 signaling in the decidua.	Oxygen	115-121	insulin like growth factor binding protein 1	Homo sapiens	11-18
21067176-4	2010	An etching evolution mechanism of the ZnO-FTO nanotubes via oxygen plasma was tentatively proposed in this study.	Oxygen	60-66	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	42-45
32538396-3	2020	Under green-light irradiation, PPNPsiRNA can sustainedly generate oxygen-independent azidyl radicals to facilitate endo/lysosomal escape through the photochemical internalization (PCI) mechanism.	Oxygen	66-72	mannosidase endo-alpha	Homo sapiens	115-119
21447598-3	2011	Our prior investigations elucidated an oxygen-dependent Cyr61 alternative splicing process characterized by retention of its intron 3, regulating its biological function in a hypoxia-driven on/off switch mechanism.	Oxygen	39-45	cellular communication network factor 1	Homo sapiens	56-61
20861276-1	2010	Apart from enhancing the production of red blood cells, erythropoietin (Epo) alters the ventilatory response when oxygen supply is reduced.	Oxygen	114-120	erythropoietin	Mus musculus	56-70
32664237-6	2020	Importantly, the combined siRNA approach against Fis1 and Drp1 prevented HG-induced changes in the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR).	Oxygen	99-105	fission, mitochondrial 1	Rattus norvegicus	49-53
20861276-1	2010	Apart from enhancing the production of red blood cells, erythropoietin (Epo) alters the ventilatory response when oxygen supply is reduced.	Oxygen	114-120	erythropoietin	Mus musculus	72-75
20930171-3	2010	METHODS AND RESULTS: Oxygen tension in the thrombus was negatively correlated with HIF1alpha levels (Spearman correlation [RS] = -0.77, P&lt;0.0001), whereas HIF1alpha levels positively correlated with vascular endothelial growth factor (VEGF) expression (Pearson correlation [R] = 0.85, P&lt;0.0005), during resolution in a murine model.	Oxygen	21-27	hypoxia inducible factor 1, alpha subunit	Mus musculus	83-92
20817051-10	2010	These data demonstrate that AnxA2 expression in osteoblasts is under the control of VEGF, which may have implications for both angiogenesis and bone mineralization under low oxygen conditions.	Oxygen	174-180	annexin A2	Mus musculus	28-33
20868356-4	2010	HO-1 is the enzyme responsible for the conversion of the heme group to billiverdin, carbon monoxide and iron; a highly regulated cytoprotective enzyme able to respond to numerous chemical or physical stressors, many of which decrease oxygen availability and generate oxidative stress.	Oxygen	234-240	heme oxygenase 1	Homo sapiens	0-4
21467030-5	2011	Various mitochondrial bioenergetic parameters, such as the oxygen consumption rate in cell cultures, enzyme activities of the electron transport chain complexes in isolated mitochondria, and production of ATP and lactate, indicated that Sirt1-KO cells exhibited higher mitochondrial respiration as compared with wild-type MEFs.	Oxygen	59-65	sirtuin 1	Mus musculus	237-242
21506136-2	2011	We have previously shown that ankyrin repeat and suppressor of cytokine signalling box protein 4 (ASB4) is the most highly differentially expressed gene in the vascular lineage during early differentiation and is expressed in the embryonic vasculature at a time when oxygen tension is rising because of the onset of placental blood flow.	Oxygen	267-273	ankyrin repeat and SOCS box-containing 4	Mus musculus	98-102
21466972-8	2011	HIF-1alpha and to a lesser extent HIF-2alpha, the oxygen-regulated HIF isoforms, have been associated with chemotherapy failure and interference with HIF function holds great promise to improve future anticancer therapy.	Oxygen	50-56	endothelial PAS domain protein 1	Homo sapiens	34-44
21397351-1	2011	D-Amino acid oxidase (DAAO) is a well-known flavoenzyme that catalyzes the oxygen-dependent oxidative deamination of amino acid D-isomers with absolute stereospecificity, which results in alpha-keto acids, ammonia and hydrogen peroxide.	Oxygen	75-81	D-amino acid oxidase	Homo sapiens	0-20
20930627-10	2010	Finally, additional studies examining the pathophysiological role of the GSTs in minimizing oxygen free radical exposure in the renal tubules during CPB may shed further light into their role as promising biomarkers of cardiac surgery-associated AKI.	Oxygen	92-98	glutathione S-transferase kappa 1	Homo sapiens	73-77
21397351-1	2011	D-Amino acid oxidase (DAAO) is a well-known flavoenzyme that catalyzes the oxygen-dependent oxidative deamination of amino acid D-isomers with absolute stereospecificity, which results in alpha-keto acids, ammonia and hydrogen peroxide.	Oxygen	75-81	D-amino acid oxidase	Homo sapiens	22-26
32664237-6	2020	Importantly, the combined siRNA approach against Fis1 and Drp1 prevented HG-induced changes in the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR).	Oxygen	99-105	collapsin response mediator protein 1	Rattus norvegicus	58-62
21397351-3	2011	Protein engineering has allowed for a redesign of DAAO substrate specificity, oxygen affinity, cofactor binding, stability, and oligomeric state.	Oxygen	78-84	D-amino acid oxidase	Homo sapiens	50-54
32754272-6	2020	The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals.	Oxygen	62-68	hydroxyacid oxidase 1, liver	Mus musculus	13-16
21355852-5	2011	Inhibition of the TRX-2 system, but not mGSH, resulted in lower ATP production (P&lt;0.001) with high metabolic activity (P&lt;0.001), low oxygen consumption (P&lt;0.001) and increased lactate production (P&lt;0.001) and caspase 3/7 activation (P&lt;0.05).	Oxygen	139-145	thioredoxin 2	Homo sapiens	18-23
20528664-5	2010	Oxygen and nutrient transport were enhanced by developing a bioreactor system for perfusing hMSC-seeded collagen gels using porous silk tubes, resulting in enhanced oxygen transport and cell viability within the gels.	Oxygen	0-6	musculin	Homo sapiens	92-96
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	Oxygen	27-33	H3 histone pseudogene 16	Homo sapiens	209-212
20528664-5	2010	Oxygen and nutrient transport were enhanced by developing a bioreactor system for perfusing hMSC-seeded collagen gels using porous silk tubes, resulting in enhanced oxygen transport and cell viability within the gels.	Oxygen	165-171	musculin	Homo sapiens	92-96
21443859-8	2011	Moreover, PPARalpha activation increased the production of CO(2) and acid soluble metabolites, which are products of fatty acid oxidation, and increased oxygen consumption rate in human adipocytes.	Oxygen	153-159	peroxisome proliferator activated receptor alpha	Homo sapiens	10-19
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	Oxygen	68-74	H3 histone pseudogene 16	Homo sapiens	209-212
32401675-0	2020	Oxygen Deficit is a Sensitive Measure of Mild Gas Exchange Impairment at Inspired O2 between 12.5%-21.	Oxygen	0-6	gastrin	Homo sapiens	46-49
32401675-0	2020	Oxygen Deficit is a Sensitive Measure of Mild Gas Exchange Impairment at Inspired O2 between 12.5%-21.	Oxygen	82-84	gastrin	Homo sapiens	46-49
21503147-7	2011	Next, we briefly presented the oxygen-sensitive molecular mechanisms regulating NSCs proliferation and differentiation recently found including the Notch, Bone morphogenetic protein and Wnt pathways.	Oxygen	31-37	bone morphogenetic protein 1	Homo sapiens	155-181
20136511-6	2010	After disulfide transfer from Tim40/Mia40 to substrate proteins, Tim40/Mia40 is reoxidized again by Erv1, which is then oxidized by electron transfer to either cytochrome c or molecular oxygen.	Oxygen	186-192	growth factor, augmenter of liver regeneration	Homo sapiens	100-104
32361652-6	2020	This study aimed to evaluate whether geniposide could inhibit the expression and activation of NLRP3 inflammasome in BV-2 microglial cells following oxygen-glucose deprivation/reoxygenation (OGD/R) and assessed whether autophagy is involved in this process.	Oxygen	149-155	NLR family, pyrin domain containing 3	Mus musculus	95-100
20679134-1	2010	Heme oxygenase 1 (HO-1) uses molecular oxygen and electrons from NADPH cytochrome P450 reductase to convert heme to CO, ferrous iron, and biliverdin (BV).	Oxygen	5-11	heme oxygenase 1	Homo sapiens	18-22
21435465-0	2011	Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.	Oxygen	52-58	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-35
21435465-0	2011	Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.	Oxygen	52-58	egl-9 family hypoxia-inducible factor 1	Mus musculus	37-41
21435465-3	2011	Here we show that prolyl hydroxylase domain protein 2 (PHD2), an enzyme mostly responsible for oxygen-induced degradation of HIF-alpha proteins, plays a major role in oxygen-induced retinopathy in mice.	Oxygen	95-101	egl-9 family hypoxia-inducible factor 1	Mus musculus	18-53
21435465-3	2011	Here we show that prolyl hydroxylase domain protein 2 (PHD2), an enzyme mostly responsible for oxygen-induced degradation of HIF-alpha proteins, plays a major role in oxygen-induced retinopathy in mice.	Oxygen	95-101	egl-9 family hypoxia-inducible factor 1	Mus musculus	55-59
21435465-3	2011	Here we show that prolyl hydroxylase domain protein 2 (PHD2), an enzyme mostly responsible for oxygen-induced degradation of HIF-alpha proteins, plays a major role in oxygen-induced retinopathy in mice.	Oxygen	167-173	egl-9 family hypoxia-inducible factor 1	Mus musculus	18-53
21435465-3	2011	Here we show that prolyl hydroxylase domain protein 2 (PHD2), an enzyme mostly responsible for oxygen-induced degradation of HIF-alpha proteins, plays a major role in oxygen-induced retinopathy in mice.	Oxygen	167-173	egl-9 family hypoxia-inducible factor 1	Mus musculus	55-59
21435465-4	2011	In neonatal mice expressing normal amounts of PHD2, exposure to 75% oxygen caused significant degradation of retinal HIF-alpha proteins, accompanied by massive losses of retinal microvessels.	Oxygen	68-74	egl-9 family hypoxia-inducible factor 1	Mus musculus	46-50
21435465-7	2011	These findings demonstrate a close association between PHD2-dependent HIF-alpha degradation and oxygen-induced retinal microvascular obliteration, and imply that PHD2 may be a promising therapeutic target to prevent oxygen-induced retinopathy.	Oxygen	96-102	egl-9 family hypoxia-inducible factor 1	Mus musculus	55-59
21435465-7	2011	These findings demonstrate a close association between PHD2-dependent HIF-alpha degradation and oxygen-induced retinal microvascular obliteration, and imply that PHD2 may be a promising therapeutic target to prevent oxygen-induced retinopathy.	Oxygen	216-222	egl-9 family hypoxia-inducible factor 1	Mus musculus	162-166
21042593-7	2010	At the functional level, we have found that Ets-1 expression is directly correlated with cellular oxygen consumption whereby increased expression causes decreased oxygen consumption.	Oxygen	98-104	ETS proto-oncogene 1, transcription factor	Homo sapiens	44-49
21042593-7	2010	At the functional level, we have found that Ets-1 expression is directly correlated with cellular oxygen consumption whereby increased expression causes decreased oxygen consumption.	Oxygen	163-169	ETS proto-oncogene 1, transcription factor	Homo sapiens	44-49
21204616-4	2011	RESULTS: Blocking ATM expression in U87MG cells increased intracellular ROS levels and sensitivity to the cytotoxic effects of IR and oxygen stress; effects that could be partly counteracted by the antioxidant N-acetylcysteine (NAC).	Oxygen	134-140	ATM serine/threonine kinase	Homo sapiens	18-21
31656272-6	2020	In vitro study showed that oxygen-glucose deprivation (OGD) treatment significantly up-regulated expressions of MEG3, Bax, and cleaved caspase-3, and further promoted apoptosis of hBMECs, while si-MEG3 blocked these effects.	Oxygen	27-33	maternally expressed 3	Homo sapiens	112-116
21479246-3	2011	Recently a mouse model was generated in which a chimeric protein consisting of HIF-1alpha oxygen-dependent degradation domain (ODD) fused to luciferase was ubiquitously expressed in all tissues.	Oxygen	90-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	79-89
20429727-6	2010	From here it was possible to identify a fraction of probesets induced at low oxygen independent of pH in these two cell lines, this fraction included HIG2, NDRG1, PAI1 and RORA.	Oxygen	77-83	serpin family E member 1	Homo sapiens	163-167
31656272-6	2020	In vitro study showed that oxygen-glucose deprivation (OGD) treatment significantly up-regulated expressions of MEG3, Bax, and cleaved caspase-3, and further promoted apoptosis of hBMECs, while si-MEG3 blocked these effects.	Oxygen	27-33	maternally expressed 3	Homo sapiens	197-201
20840605-7	2010	In vitro, overexpression of miR-21 in cultured cortical neurons substantially suppressed oxygen and glucose deprivation-induced apoptotic cell death, whereas attenuation of endogenous miR-21 by antisense inhibition exacerbated cell death after oxygen and glucose deprivation.	Oxygen	89-95	microRNA 21	Homo sapiens	28-34
31898397-2	2020	Reactive oxygen and nitrogen species (ROS/RNS) are among the various factors affecting the host as well as the implant components.	Oxygen	9-15	FAM20C golgi associated secretory pathway kinase	Homo sapiens	42-45
20840605-7	2010	In vitro, overexpression of miR-21 in cultured cortical neurons substantially suppressed oxygen and glucose deprivation-induced apoptotic cell death, whereas attenuation of endogenous miR-21 by antisense inhibition exacerbated cell death after oxygen and glucose deprivation.	Oxygen	244-250	microRNA 21	Homo sapiens	28-34
21397862-0	2011	Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors.	Oxygen	67-69	angiopoietin like 4	Homo sapiens	0-27
32212372-5	2020	Loaded with a cobalt phthalocyanine-based cathode catalyst, our hybrid electrode achieves a CO Faradaic efficiency of 71% with 10% O 2 in the CO 2 feed gas.	Oxygen	131-134	complement C2	Homo sapiens	142-146
21214231-1	2011	Quantum chemical analysis was carried out to model metabolism of glitazone class of drugs through oxygen transfer process to the sulfur atom of thiazolidinedione ring with different oxidants such as H(2)O(2), HOONO, and C4a-hydroperoxyflavin.	Oxygen	98-104	complement C4A (Rodgers blood group)	Homo sapiens	220-223
21204551-4	2011	A remarkable and unexpected result for the laccase/HBT oxidative system has been the chemoselective insertion of the oxygen atom into the C-4-H bond of catechin derivatives.	Oxygen	117-123	complement C4A (Rodgers blood group)	Homo sapiens	138-141
20654592-2	2010	Moderate hypoxia (5% oxygen) markedly stimulates PNMT promoter-driven luciferase activity in the cells.	Oxygen	21-27	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-53
20701279-6	2010	Furthermore, the Cu(2+) center(s) can be readily reduced to Cu(+), and possible reactions of alpha-syn-Cu(2+) with cellular species (e.g., O(2), ascorbic acid, and dopamine) were investigated.	Oxygen	139-143	synuclein alpha	Homo sapiens	93-102
32482065-3	2020	The Dexter type super-exchange via charge transfer states (Car +/O2 -) governs the 1O2 quenching.	Oxygen	65-67	CXADR Ig-like cell adhesion molecule	Sus scrofa	59-62
20643143-4	2010	We present here a novel structure of human PrxV at 1.45 A resolution that has a dithiothreitol bound in the active site with its diol moiety mimicking the two oxygens of a peroxide substrate.	Oxygen	159-166	peroxiredoxin 5	Homo sapiens	43-47
21219576-0	2011	Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-kappaB activity in pancreatic islets depends on oxygen availability.	Oxygen	135-141	inhibitor of kappaB kinase beta	Mus musculus	63-71
32482065-4	2020	The Car +/O2 - states are substantially higher in energy (2-4 eV) than the initial 1Car/1O2 states.	Oxygen	10-12	CXADR Ig-like cell adhesion molecule	Sus scrofa	4-7
32482065-6	2020	The super-exchange mechanism via the Car +/O2 - states dominates the 1O2 quenching, though the direct two-electron coupling can also play a certain role.	Oxygen	43-45	CXADR Ig-like cell adhesion molecule	Sus scrofa	37-40
20578959-7	2011	Enhanced mitochondrial oxidative stress in PON2-def mice was accompanied by significantly reduced ETC complex I + III activities, oxygen consumption, and adenosine triphosphate levels in PON2-def mice.	Oxygen	130-136	paraoxonase 2	Mus musculus	43-47
32599765-1	2020	Myoglobin (Mb), an oxygen-binding heme protein highly expressed in heart and skeletal muscle, has been shown to undergo oxidative modifications on both an inter- and intramolecular level when exposed to hydrogen peroxide (H2O2) in vitro.	Oxygen	19-25	myoglobin	Homo sapiens	0-9
21215626-2	2011	Here we report a new synthetic small molecule targeting the mitochondrial oxygen sensor UQCRB that was identified by pharmacophore-based virtual screening and in vitro and in vivo competition binding analyses.	Oxygen	74-80	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	88-93
21215626-5	2011	These results demonstrated that HDNT is a novel synthetic small molecule targeting UQCRB and exhibits anti-angiogenic activity by modulating the oxygen-sensing function of UQCRB.	Oxygen	145-151	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	172-177
20558753-0	2010	Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons.	Oxygen	38-44	carbonic anhydrase 1	Rattus norvegicus	116-119
20558760-10	2010	Compared with LCR rats, HCR rats fortify wheel running with increased food consumption along with greater hypertrophy of key organs for O2 transport.	Oxygen	136-138	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	24-27
19660198-8	2010	Both N-methyl-D-aspartic acid (NMDA) receptor antagonist (ketamine) and oxygen free radical scavenger (alpha-tocopherol) decreased AMPK activity as well as the content of GLUT4 in the plasma membrane following cerebral ischemia.	Oxygen	72-78	solute carrier family 2 member 4	Rattus norvegicus	171-176
20666645-3	2010	We hypothesized that LOX-1 is up-regulated by psychological stress via the formation of oxygen-derived free radicals, and that treatment with EUK-8 (a superoxide dismutase and catalase mimetic) prevents production of oxygen-derived free radicals and leads to reduced expression of LOX-1 in the vascular wall.	Oxygen	88-94	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	21-26
32450696-11	2020	The data of the Gd3+-containing samples indicates that the average charge density around the Eu3+ ions in the lattice is decreased with increasing Gd3+ and oxygen vacancy concentration.	Oxygen	156-162	GRDX	Homo sapiens	16-19
20559021-6	2010	Western blot analysis revealed that hypoxia (1% O2, 8 h) induced HIF-1alpha and HIF-2alpha expression in different gastric cancer cell lines, including SGC7901, AGS, MGC803 and MKN45.	Oxygen	48-50	endothelial PAS domain protein 1	Homo sapiens	80-90
32452684-1	2020	Low temperature anaerobic methane conversion to methanol (MTM) using copper ion-exchanged mordenite (Cu-MOR) as the catalyst and water as the sole source of oxygen is promising for sustainable utilization of methane.	Oxygen	157-163	opioid receptor mu 1	Homo sapiens	104-107
21850930-1	2010	Recently positive correlation has been found between oxygen consumption (ZO2) in bull spermatozoa and non-return rates and concluded that an increase in ZO2, characteristic of the freeze/thaw process, was possibly associated with mitochondrial membrane damage during this procedure: alternatively, sperm may be hyperactivated through the capacitation-like effects of freezing/thawing.	Oxygen	53-59	tight junction protein 2	Bos taurus	73-76
32587983-12	2020	CONCLUSIONS: In high-risk COVID-19 patients with severe pneumonia, GM-CSF neutralization with lenzilumab was safe and associated with improved clinical outcomes, oxygen requirement, and cytokine storm.	Oxygen	162-168	colony stimulating factor 2	Homo sapiens	67-73
21850930-1	2010	Recently positive correlation has been found between oxygen consumption (ZO2) in bull spermatozoa and non-return rates and concluded that an increase in ZO2, characteristic of the freeze/thaw process, was possibly associated with mitochondrial membrane damage during this procedure: alternatively, sperm may be hyperactivated through the capacitation-like effects of freezing/thawing.	Oxygen	53-59	tight junction protein 2	Bos taurus	153-156
20498362-1	2010	Molecular dynamics simulations and implicit ligand sampling methods have identified trajectories and sites of high affinity for O(2) in the protein framework of the flavoprotein D-amino-acid oxidase (DAAO).	Oxygen	128-132	D-amino acid oxidase	Homo sapiens	178-198
20498362-1	2010	Molecular dynamics simulations and implicit ligand sampling methods have identified trajectories and sites of high affinity for O(2) in the protein framework of the flavoprotein D-amino-acid oxidase (DAAO).	Oxygen	128-132	D-amino acid oxidase	Homo sapiens	200-204
32595496-7	2020	Concurrent neutralization of TNF-alpha, IL-1beta, and IL-6 with their antibodies provided better reduction in oxygen and glucose deprivation-induced increases in scar markers than obtained with separate use of each antibody.	Oxygen	110-116	interleukin 1 alpha	Homo sapiens	40-48
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	Oxygen	54-62	indoleamine 2,3-dioxygenase 1	Homo sapiens	238-241
20361220-5	2010	Our data suggest that the deprotonation of the indoleamine group of the substrate by either histidine in TDO or heme-bound dioxygen in IDO is not energetically favorable.	Oxygen	123-131	indoleamine 2,3-dioxygenase 1	Homo sapiens	135-138
32525699-9	2021	The percentage of sleep time with oxygen saturation below 90% (CT90) was the only predictive parameter for surgical success (P = .014, odds ratio value = 0.894).	Oxygen	34-40	kinesin family member 20B	Homo sapiens	63-67
20361220-9	2010	The results reveal the subtle differences between the TDO and IDO reactions and highlight the importance of protein matrix in modulating stereoelectronic factors for oxygen activation and the stabilization of both transition and intermediate states.	Oxygen	166-172	indoleamine 2,3-dioxygenase 1	Homo sapiens	62-65
32487192-16	2020	Elevated PKM2 in vitro is associated with increased utilization of the glycolysis pathway, resulting in oxygen independent cell metabolism.	Oxygen	104-110	pyruvate kinase M1/2	Homo sapiens	9-13
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Oxygen	80-86	Alternative oxidase family protein	Arabidopsis thaliana	0-24
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Oxygen	80-86	Alternative oxidase family protein	Arabidopsis thaliana	26-30
32315212-5	2020	Infusion of RANKL induced browning and elevated respiratory rates in sWAT, along with increased whole body oxygen consumption in mice measured by indirect calorimetry.	Oxygen	107-113	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	12-17
19729061-10	2010	Our results suggest that rEpo generates its protective effect against oxygen toxicity by a reduction of diverse oxidative stress parameters and by limiting the stressor-inducible changes in both HO-1 and cholinergic functions.	Oxygen	70-76	erythropoietin	Rattus norvegicus	25-29
32516564-8	2020	Moreover, SLN transcript abundance negatively correlated with peak oxygen consumption under cold exposure (a proxy for ST) across individuals, and higher SLN transcript abundance escalated an individual"s risk of hypothermia in acute cold.	Oxygen	67-73	sarcolipin	Homo sapiens	10-13
20444987-0	2010	Myoglobin: safeguard of myocardial oxygen supply during systolic compression?	Oxygen	35-41	myoglobin	Homo sapiens	0-9
32512511-0	2020	Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.	Oxygen	4-10	CD1d molecule	Homo sapiens	43-47
20585450-4	2010	PRINCIPAL FINDINGS: Exposure of skeletal and cardiac myosins to physiological concentrations of nitrogen oxides, including the endogenous nitrosothiol S-nitroso-L-cysteine, reduced the velocity of actin filaments over myosin in a dose-dependent and oxygen-dependent manner, caused a doubling of force as measured in a laser trap transducer, and caused S-nitrosylation of cysteines in the myosin heavy chain.	Oxygen	249-255	myosin heavy chain 14	Homo sapiens	53-59
20231286-2	2010	The heme cofactor of alpha1beta1 sGC has a high affinity for NO but has never been observed to form a complex with oxygen.	Oxygen	115-121	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	33-36
20231286-3	2010	Introduction of a key tyrosine residue in the sGC heme binding domain beta1(1-385) is sufficient to produce an oxygen-binding protein, but this mutation in the full-length enzyme did not alter oxygen affinity.	Oxygen	111-117	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	46-49
32344470-5	2020	More importantly, in vitro experiments demonstrated that down-regulation of TNF-alpha in oxygen-glucose deprivation/reoxygenation (OGD/R) cells increased cell viability and decreased apoptosis and the p53 expression.	Oxygen	89-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	201-204
20219824-0	2010	Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells.	Oxygen	10-16	erythropoietin	Mus musculus	59-73
20219824-1	2010	The kidney is a major site of systemic oxygen sensing, regulating blood erythrocyte and hence oxygen content by hypoxia-inducible erythropoietin (Epo) expression.	Oxygen	39-45	erythropoietin	Mus musculus	130-144
20219824-1	2010	The kidney is a major site of systemic oxygen sensing, regulating blood erythrocyte and hence oxygen content by hypoxia-inducible erythropoietin (Epo) expression.	Oxygen	39-45	erythropoietin	Mus musculus	146-149
20219824-2	2010	A constant ratio between blood perfusion and oxygen consumption, a stable corticomedullary oxygen gradient, and a relatively low tissue Po(2) are the prerequisites for the function of renal Epo-producing and oxygen-sensing (REPOS) cells, which are located in the juxtamedullary cortex.	Oxygen	45-51	erythropoietin	Mus musculus	190-193
31823886-5	2020	Enzyme-linked immunosorbent assays and western blotting showed that after oxygen-glucose deprivation, the secreted and intracellular levels of BDNF were significantly reduced and the intracellular level of PC1/3 was decreased.	Oxygen	74-80	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	206-211
20219824-2	2010	A constant ratio between blood perfusion and oxygen consumption, a stable corticomedullary oxygen gradient, and a relatively low tissue Po(2) are the prerequisites for the function of renal Epo-producing and oxygen-sensing (REPOS) cells, which are located in the juxtamedullary cortex.	Oxygen	91-97	erythropoietin	Mus musculus	190-193
20219824-2	2010	A constant ratio between blood perfusion and oxygen consumption, a stable corticomedullary oxygen gradient, and a relatively low tissue Po(2) are the prerequisites for the function of renal Epo-producing and oxygen-sensing (REPOS) cells, which are located in the juxtamedullary cortex.	Oxygen	91-97	erythropoietin	Mus musculus	190-193
20219824-4	2010	The molecular principles of cellular oxygen sensing have been elucidated in the last few years, and genetically altered mouse models as well as hereditary diseases causing erythrocytosis have clarified the oxygen-signaling cascade leading to increased Epo expression in REPOS cells.	Oxygen	206-212	erythropoietin	Mus musculus	252-255
31823886-6	2020	Transient transfection of cortical neurons with a PC1/3 overexpression plasmid followed by oxygen-glucose deprivation resulted in increased PC1/3 levels and increased BDNF levels.	Oxygen	91-97	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	140-145
20495570-4	2010	HIF-2alpha, independently of oxygen-dependent hydroxylation, was essential for endochondral ossification of cultured chondrocytes and embryonic skeletal growth in mice.	Oxygen	29-35	endothelial PAS domain protein 1	Mus musculus	0-10
32317394-4	2020	The exposure of cancer cells to 1% O2 for 24 hours triggered ~2-fold up-regulation of CD73, without affecting nucleoside transporters, adenosine kinase activity and cellular ATP content.	Oxygen	35-37	5' nucleotidase, ecto	Mus musculus	86-90
32439831-7	2020	NADPH oxidase 5 (NOX5) was identified as a potential target of miR-15a-3p, and the inhibition of NOX5 reduced the release of reactive oxygen species, thereby impairing the functionality of human umbilical vein endothelial cells.	Oxygen	134-140	NADPH oxidase 5	Homo sapiens	97-101
20392104-0	2010	Effect of heme modification on oxygen affinity of myoglobin and equilibrium of the acid-alkaline transition in metmyoglobin.	Oxygen	31-37	myoglobin	Homo sapiens	50-59
32455741-4	2020	FTMT is an iron-sequestering protein primarily expressed in metabolically active cells and tissues with high oxygen demand, including retina.	Oxygen	109-115	ferritin mitochondrial	Homo sapiens	0-4
20406905-0	2010	Role of macroscopic particles in deep-sea oxygen consumption.	Oxygen	42-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	38-41
32553077-0	2020	Hyperbaric Oxygen Treatment Improves Hearing Level via Attenuating TLR4/NF-kappaB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients.	Oxygen	11-17	toll like receptor 4	Homo sapiens	67-71
20298504-2	2010	In many bacteria, the oxygen-sensitive regulator FNR activates anaerobic respiration, and a preliminary study using the light-generating lux genes from V. fischeri MJ1 cloned in Escherichia coli suggested that FNR stimulates bioluminescence.	Oxygen	22-28	fnr	Vibrio fischeri ES114	49-52
20298504-2	2010	In many bacteria, the oxygen-sensitive regulator FNR activates anaerobic respiration, and a preliminary study using the light-generating lux genes from V. fischeri MJ1 cloned in Escherichia coli suggested that FNR stimulates bioluminescence.	Oxygen	22-28	fnr	Vibrio fischeri ES114	210-213
32416225-0	2020	Reduction in CYP1A1 and 2B2 activity at low oxygen tension.	Oxygen	44-50	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-27
20556201-1	2010	Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen.	Oxygen	206-212	tryptophan hydroxylase 1	Homo sapiens	30-34
20880076-9	2011	RESULTS: Exposure of primary mouse HSCs to 0.5% oxygen activated HIF-1alpha and HIF-2alpha.	Oxygen	48-54	hypoxia inducible factor 1, alpha subunit	Mus musculus	65-75
20880076-9	2011	RESULTS: Exposure of primary mouse HSCs to 0.5% oxygen activated HIF-1alpha and HIF-2alpha.	Oxygen	48-54	endothelial PAS domain protein 1	Mus musculus	80-90
32416225-7	2020	Using alkoxyresorufin molecules as substrates, the Vmax/Km ratios for resorufin production decreased from 426 to 393 for CYP1A1 and from 343 to 202 for CYP2B1 at a low oxygen concentration (4.1 ppm) compared to the ratios observed at a normal oxygen concentration (6.5 ppm).	Oxygen	168-174	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	121-127
21057375-2	2011	We tested the hypothesis that JB1 (an IGF-I analog) prevents oxygen-induced retinopathy in our rat model.	Oxygen	61-67	insulin-like growth factor 1	Rattus norvegicus	38-43
31488552-7	2020	Retroviral expression of VP16-HIF-1alpha in SCs increased HIF-alpha by 5.9-fold and its target genes implicated in oxygen transport and delivery (VEGF, 2.2-fold) and cellular metabolism (enolase, 1.7-fold).	Oxygen	115-121	vascular endothelial growth factor A	Rattus norvegicus	146-150
21081489-9	2011	Experiments to identify how miR-200b modulates angiogenesis under a low oxygen environment illustrated that hypoxia-induced miR-200b down-regulation de-repressed Ets-1 expression to promote angiogenesis.	Oxygen	72-78	ETS proto-oncogene 1, transcription factor	Homo sapiens	162-167
20975668-5	2010	SCO2-/- cells have increased intracellular oxygen and nicotinamide adenine dinucleotide (NADH) levels, which result in increased ROS and oxidative DNA damage.	Oxygen	43-49	synthesis of cytochrome C oxidase 2	Homo sapiens	0-4
20145250-4	2010	Overexpression of UQCRB or its suppression using RNA interference demonstrates that it plays a crucial role in the oxygen sensing mechanism that regulates responses to hypoxia.	Oxygen	115-121	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	18-23
20308573-5	2010	Molecular oxygen is required for [PSI(+)] prion formation as growth under anaerobic conditions prevents prion formation in the tsa1 tsa2 mutant.	Oxygen	10-16	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	127-131
21178669-6	2011	Median minimal preoperative oxygen supplemented Sco2 (Sco2min-ox) was 64% (range: 15-92%).	Oxygen	28-34	synthesis of cytochrome C oxidase 2	Homo sapiens	54-64
31943079-0	2020	The non-photochemical quenching protein LHCSR3 prevents oxygen-dependent photoinhibition in Chlamydomonas reinhardtii.	Oxygen	56-62	uncharacterized protein	Chlamydomonas reinhardtii	40-46
20139087-7	2010	Deletion of TSA1 or TRR1 is synthetically lethal in Deltamrs3Deltamrs4 cells, suggesting that Deltamrs3Deltamrs4 cells generate reactive oxygen metabolites.	Oxygen	137-143	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	12-16
20139087-7	2010	Deletion of TSA1 or TRR1 is synthetically lethal in Deltamrs3Deltamrs4 cells, suggesting that Deltamrs3Deltamrs4 cells generate reactive oxygen metabolites.	Oxygen	137-143	thioredoxin-disulfide reductase TRR1	Saccharomyces cerevisiae S288C	20-24
19849792-0	2010	The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats.	Oxygen	94-100	mitogen-activated protein kinase 8	Rattus norvegicus	4-27
19849792-0	2010	The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats.	Oxygen	94-100	mitogen-activated protein kinase 8	Rattus norvegicus	29-32
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	Oxygen	60-66	Alternative oxidase family protein	Arabidopsis thaliana	4-28
20135683-4	2010	Significantly, low O(2) levels promote vascular development and maturation in wild-type (WT) ESC cultures measured by an increase in the numbers of CD31(+) endothelial cells (ECs) and sprouting angiogenic EBs, but refractory in Arnt(-/-) and Vegf(-/-) ESC cultures.	Oxygen	19-23	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	228-232
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	Oxygen	60-66	Alternative oxidase family protein	Arabidopsis thaliana	30-34
32275815-4	2020	Using isotopic labeling, acid titration, and in situ gas analysis, we show the presence of O2 and CO2 evolution in both systems, albeit with different cumulative amounts, and possible SO2 evolution for the lithium thiophosphate-based cells.	Oxygen	91-93	gastrin	Homo sapiens	53-56
31825666-4	2020	Consistently, hypoxia/reoxygenation (H/R)-treated cardiac (H9c2) cells displayed cellular injury (apoptosis and necrosis), up-regulation of total and mitochondrial protein levels of Mul1 and p53, and enhanced interactions between p53 and SUMO1 concomitant with mitochondrial dysfunctions (increase in mitochondrial membrane potential and reactive oxygen species production while decrease in ATP production); these phenomena were attenuated by knockdown of Mul1 expression.	Oxygen	24-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	191-194
19900484-3	2010	HIFs are transcription factors involved in the cellular response to low oxygen, including upregulation of transcripts like vascular endothelial growth factor (VEGF) and EPO.	Oxygen	72-78	erythropoietin	Mus musculus	169-172
20160103-5	2010	Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption.	Oxygen	161-167	growth hormone	Mus musculus	13-15
31825666-4	2020	Consistently, hypoxia/reoxygenation (H/R)-treated cardiac (H9c2) cells displayed cellular injury (apoptosis and necrosis), up-regulation of total and mitochondrial protein levels of Mul1 and p53, and enhanced interactions between p53 and SUMO1 concomitant with mitochondrial dysfunctions (increase in mitochondrial membrane potential and reactive oxygen species production while decrease in ATP production); these phenomena were attenuated by knockdown of Mul1 expression.	Oxygen	24-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	230-233
20160103-5	2010	Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption.	Oxygen	161-167	growth hormone	Mus musculus	45-47
20160103-5	2010	Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption.	Oxygen	202-208	growth hormone	Mus musculus	13-15
31825666-4	2020	Consistently, hypoxia/reoxygenation (H/R)-treated cardiac (H9c2) cells displayed cellular injury (apoptosis and necrosis), up-regulation of total and mitochondrial protein levels of Mul1 and p53, and enhanced interactions between p53 and SUMO1 concomitant with mitochondrial dysfunctions (increase in mitochondrial membrane potential and reactive oxygen species production while decrease in ATP production); these phenomena were attenuated by knockdown of Mul1 expression.	Oxygen	24-30	mitochondrial E3 ubiquitin protein ligase 1	Rattus norvegicus	456-460
32202355-11	2020	Taken together, improved blood preservation solution could enhance the oxygen carrying capacity of red blood cells and wound healing in mice with diabetes, which is achieved through regulation of HIF-1alpha pathway.	Oxygen	71-77	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-206
20023176-5	2010	We found that chronic oxygen-induced lung injury decreased pulmonary sGCalpha(1) and PKGI immunoreactivity in mouse pups and that exposure to a TGF-beta-neutralizing antibody prevented this reduction of sGC and PKGI protein expression.	Oxygen	22-28	protein kinase cGMP-dependent 1	Rattus norvegicus	85-89
20023176-5	2010	We found that chronic oxygen-induced lung injury decreased pulmonary sGCalpha(1) and PKGI immunoreactivity in mouse pups and that exposure to a TGF-beta-neutralizing antibody prevented this reduction of sGC and PKGI protein expression.	Oxygen	22-28	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	69-72
20023176-5	2010	We found that chronic oxygen-induced lung injury decreased pulmonary sGCalpha(1) and PKGI immunoreactivity in mouse pups and that exposure to a TGF-beta-neutralizing antibody prevented this reduction of sGC and PKGI protein expression.	Oxygen	22-28	protein kinase cGMP-dependent 1	Rattus norvegicus	211-215
32525819-2	2020	The aim of the present study was to investigate the role of miR-19a and its possible target genes in SK-N-SH cells subjected to oxygen-glucose deprivation/re-oxygenation (OGD/R) injury.	Oxygen	128-134	microRNA 19a	Homo sapiens	60-67
20064662-0	2010	Effect of dioxygen on copper(II) binding to alpha-synuclein.	Oxygen	10-18	synuclein alpha	Homo sapiens	44-59
32208891-0	2020	Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.	Oxygen	83-85	olfactory receptor family 51 subfamily E member 2	Mus musculus	0-21
20107925-0	2010	Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF.	Oxygen	0-6	vascular endothelial growth factor A	Rattus norvegicus	95-99
32296880-2	2020	We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient (Hif-p4h-2gt/gt) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet.	Oxygen	114-120	egl-9 family hypoxia-inducible factor 1	Mus musculus	38-85
20107925-6	2010	The hypoxic target gene Vegf was implicated as a neurotrophic factor, as neurite formation at 21% oxygen was mimicked with exogenous VEGF, and a VEGF-neutralizing antibody attenuated neurite formation under reduced oxygen conditions.	Oxygen	98-104	vascular endothelial growth factor A	Rattus norvegicus	24-28
20107925-6	2010	The hypoxic target gene Vegf was implicated as a neurotrophic factor, as neurite formation at 21% oxygen was mimicked with exogenous VEGF, and a VEGF-neutralizing antibody attenuated neurite formation under reduced oxygen conditions.	Oxygen	215-221	vascular endothelial growth factor A	Rattus norvegicus	24-28
20107925-6	2010	The hypoxic target gene Vegf was implicated as a neurotrophic factor, as neurite formation at 21% oxygen was mimicked with exogenous VEGF, and a VEGF-neutralizing antibody attenuated neurite formation under reduced oxygen conditions.	Oxygen	215-221	vascular endothelial growth factor A	Rattus norvegicus	145-149
20107925-7	2010	These findings demonstrate that behavior of neural-like cells is driven by the oxygen microenvironment via VEGF function, and suggest promising approaches for future applications in neural repair.	Oxygen	79-85	vascular endothelial growth factor A	Rattus norvegicus	107-111
20010314-5	2010	Receiving 100% oxygen for 30 min without preceding hypoxia decreased the expression of VEGFR2 and TGFBR3 mRNA in liver tissue, but not in lung tissue.	Oxygen	15-21	transforming growth factor beta receptor 3	Sus scrofa	98-104
20121059-1	2010	We report the first isomeric-selective study of the dominant isomeric pathway in the OH-initiated oxidation of isoprene in the presence of O2 and NO using the laser photolysis-laser induced fluorescence (LP-LIF) technique.	Oxygen	139-141	LIF interleukin 6 family cytokine	Homo sapiens	207-210
32296880-2	2020	We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient (Hif-p4h-2gt/gt) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet.	Oxygen	114-120	egl-9 family hypoxia-inducible factor 1	Mus musculus	87-96
32017943-4	2020	Here we show that Fbln7-C inhibits neovascularization in vivo, in both a model of wet AMD involving choroidal neovascularization (CNV) and diabetic retinopathy involving oxygen-induced ischemic retinopathy.	Oxygen	170-176	fibulin 7	Homo sapiens	18-23
20140248-3	2010	In vitro, MSCs significantly increased tPA levels and concomitantly reduced plasminogen activator inhibitor 1 (PAI-1) expression in astrocytes under normal and oxygen and glucose deprivation (OGD) conditions.	Oxygen	160-166	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	111-116
32376950-6	2020	Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappaB and the upregulation of Ascl1.	Oxygen	151-157	axin 2	Mus musculus	80-85
19661235-9	2010	Retinal cPLA(2) activity peaked 1 day after oxygen exposure in OIR rats.	Oxygen	44-50	phospholipase A2 group IVA	Rattus norvegicus	8-15
32397891-8	2020	Oxygen challenge test value (PaO2-OCT) with best prediction was 31 kPa (232 mmHg; sensitivity 0.74; specificity 0.70; area under curve 0.77 (confidence interval: 0.73-0.81)).	Oxygen	0-6	plexin A2	Homo sapiens	34-37
20016470-1	2010	The adaptation of erythropoietin production to oxygen supply is determined by the abundance of hypoxia-inducible factor (HIF), a regulation that is induced by a prolyl hydroxylase.	Oxygen	47-53	erythropoietin	Rattus norvegicus	18-32
32203650-1	2020	Metal-nitrogen-carbon (MNC) nanocomposites have been hailed as promising, efficient electrocatalysts toward oxygen reduction reaction (ORR) due to the formation of MNx coordination moieties.	Oxygen	108-114	keratin 86	Homo sapiens	164-167
19917609-3	2010	X-ray crystal structures of Rhodobacter capsulatus ALAS reveal that a conserved active site serine moves to within hydrogen bonding distance of the phenolic oxygen of the PLP cofactor in the closed substrate-bound enzyme conformation and within 3-4 A of the thioester sulfur atom of bound succinyl-CoA.	Oxygen	157-163	aminolevulinic acid synthase 1	Mus musculus	51-55
32271890-0	2020	Endothelial Yes-Associated Protein 1 Promotes Astrocyte Proliferation and Maturation via Cytoplasmic Leukemia Inhibitory Factor Secretion in Oxygen-Induced Retinopathy.	Oxygen	141-147	leukemia inhibitory factor	Mus musculus	101-127
20024993-3	2010	Electrochemical measurements demonstrate that the PtNW--Sn@CNT 3D electrode exhibits enhanced electrocatalytic performance in oxygen reduction reaction (ORR) for polymer electrolyte membrane fuel cells (PEMFCs), methanol oxidation (MOR) for direct methanol fuel cells (DMFCs), and CO tolerance compared with commercial ETEK Pt/C catalyst made of Pt nanoparticles.	Oxygen	126-132	opioid receptor mu 1	Homo sapiens	232-235
32714599-9	2020	Both oxygen changes caused barriers to release factors that decreased GluN1, GABAAalpha1 staining and increased GluN3a staining.	Oxygen	5-11	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	112-118
21077764-0	2010	Hb Cambridge-MA [beta144(HC1)-beta146(HC3)Lys-Tyr-His 0 (HBB c.433 A>T)]: a new high oxygen affinity variant.	Oxygen	85-91	hemoglobin subunit beta	Homo sapiens	57-60
32212691-4	2020	For Am, there is a divalent [AnII(O2)]2+ structure where the dioxygen is an end-on physisorbed eta1-3O2 2 kcal/mol above the actinyl when spin-orbit effects are included which lower the energy of the actinyl structure.	Oxygen	61-69	secreted phosphoprotein 1	Homo sapiens	95-99
20304439-0	2010	The oxygen fluxes of sandy littoral areas: quantifying primary and secondary producers in the Baltic Sea.	Oxygen	4-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
31958455-7	2020	The results demonstrate that PDGF-BB up-regulates BMAL1 expression through reactive oxygen species/ERK/Egr-1 pathways and that BMAL1 is involved in PDGF-BB-induced cell proliferation partially through ERK in VSMCs.	Oxygen	84-90	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	50-55
20304439-1	2010	The study aimed to estimate the total oxygen flow through the shallow littoral of the Gulf of Gdansk (southern Baltic Sea).	Oxygen	38-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
32154725-0	2020	Full Energy Range Resonant Inelastic X-ray Scattering of O2 and CO2: Direct Comparison with Oxygen Redox State in Batteries.	Oxygen	92-98	complement C2	Homo sapiens	27-67
19755933-5	2010	On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure.	Oxygen	77-79	C-C motif chemokine ligand 2	Homo sapiens	8-13
19755933-6	2010	After adjusting for covariates, prolonged early O2 exposure retained a statistically significant association with higher MCP 1 on d 3 (p = 0.003).	Oxygen	48-50	C-C motif chemokine ligand 2	Homo sapiens	121-126
19755933-7	2010	The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted.	Oxygen	35-37	C-C motif chemokine ligand 2	Homo sapiens	51-56
20637316-0	2011	Stabilization and spectroscopic characterization of the dioxygen complex of wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and proximal side F429H mutants at subzero temperatures.	Oxygen	56-64	cytochrome P450 2B4	Oryctolagus cuniculus	106-112
20637316-2	2011	To probe the interactions of the heme environment and bound benzphetamine with the dioxygen (O2) complex of CYP2B4, homogeneous O2 complexes of the wild-type enzyme and three mutants at sites of conserved amino acids, two on the heme distal side (T302A and E301Q) and one on the proximal side (F429H), have been prepared and stabilized at ~-50 C in mixed solvents (60-70% v/v glycerol).	Oxygen	83-91	cytochrome P450 2B4	Oryctolagus cuniculus	108-114
20637316-2	2011	To probe the interactions of the heme environment and bound benzphetamine with the dioxygen (O2) complex of CYP2B4, homogeneous O2 complexes of the wild-type enzyme and three mutants at sites of conserved amino acids, two on the heme distal side (T302A and E301Q) and one on the proximal side (F429H), have been prepared and stabilized at ~-50 C in mixed solvents (60-70% v/v glycerol).	Oxygen	93-95	cytochrome P450 2B4	Oryctolagus cuniculus	108-114
20637316-3	2011	We report that the magnetic circular dichroism and electronic absorption spectra of wild-type oxyferrous CYP2B4, in the presence and absence of substrate, are quite similar to those of the dioxygen complex of bacterial cytochrome P450-CAM (CYP101).	Oxygen	189-197	cytochrome P450 2B4	Oryctolagus cuniculus	105-111
20671746-5	2011	A very low O(2) concentration (0.1%) induces CD34(+) quiescence in G(0).	Oxygen	11-15	CD34 antigen	Mus musculus	45-49
21113404-3	2010	We sought to investigate how changes in oxygen tension might directly impact muscle PPAR regulation of oxidative genes.	Oxygen	40-46	peroxisome proliferator activated receptor alpha	Homo sapiens	84-88
21113404-4	2010	Following eight days in culture at 1% oxygen, C(2)C(12) muscle myoblasts displayed a reduction of PGC-1alpha, PPAR-alpha, and RXR-alpha mRNA, as well as CPT-1b and UCP-2 mRNA.	Oxygen	38-44	peroxisome proliferator activated receptor alpha	Homo sapiens	110-120
19755485-4	2010	We report that culture at 20% oxygen decreased hES cell proliferation and resulted in a significantly reduced expression of SOX2, NANOG and POU5F1 (OCT4) mRNA as well as POU5F1 protein compared with hypoxic conditions.	Oxygen	30-36	POU class 5 homeobox 1	Homo sapiens	140-146
19755485-4	2010	We report that culture at 20% oxygen decreased hES cell proliferation and resulted in a significantly reduced expression of SOX2, NANOG and POU5F1 (OCT4) mRNA as well as POU5F1 protein compared with hypoxic conditions.	Oxygen	30-36	POU class 5 homeobox 1	Homo sapiens	148-152
19755485-4	2010	We report that culture at 20% oxygen decreased hES cell proliferation and resulted in a significantly reduced expression of SOX2, NANOG and POU5F1 (OCT4) mRNA as well as POU5F1 protein compared with hypoxic conditions.	Oxygen	30-36	POU class 5 homeobox 1	Homo sapiens	170-176
31967857-2	2020	Three oxygen sensing enzyme complexes may be used for this purpose: 1) mitochondrial electron transport chain metabolism, 2) heme oxygenase 2 (HO-2) generating CO and/or 3) an NAD(P)H oxidase (NOX).	Oxygen	6-12	heme oxygenase 2	Mus musculus	125-141
19755485-6	2010	HIF2A (EPAS1) and HIF3A displayed a cytoplasmic localisation during initial hypoxic culture but translocated to the nucleus following long-term culture at 5% oxygen and were significantly upregulated compared with cells cultured at 20% oxygen.	Oxygen	158-164	endothelial PAS domain protein 1	Homo sapiens	0-5
19755485-6	2010	HIF2A (EPAS1) and HIF3A displayed a cytoplasmic localisation during initial hypoxic culture but translocated to the nucleus following long-term culture at 5% oxygen and were significantly upregulated compared with cells cultured at 20% oxygen.	Oxygen	158-164	endothelial PAS domain protein 1	Homo sapiens	7-12
19755485-6	2010	HIF2A (EPAS1) and HIF3A displayed a cytoplasmic localisation during initial hypoxic culture but translocated to the nucleus following long-term culture at 5% oxygen and were significantly upregulated compared with cells cultured at 20% oxygen.	Oxygen	236-242	endothelial PAS domain protein 1	Homo sapiens	0-5
20700422-3	2010	The expression of monocyte chemotactic protein-1 (MCP-1) mRNA induced by H/R in SHRSP/IZM astrocytes was increased compared with that in normal oxygen concentrations.	Oxygen	144-150	C-C motif chemokine ligand 2	Rattus norvegicus	18-48
20700422-3	2010	The expression of monocyte chemotactic protein-1 (MCP-1) mRNA induced by H/R in SHRSP/IZM astrocytes was increased compared with that in normal oxygen concentrations.	Oxygen	144-150	C-C motif chemokine ligand 2	Rattus norvegicus	50-55
22178933-3	2011	HIF-1alpha/ beta and HIF-2alpha/ beta are transcriptional activators of oxygen-regulated genes.	Oxygen	72-78	endothelial PAS domain protein 1	Homo sapiens	21-31
21929765-3	2011	Low preoperative cerebral oxygen saturation (ScO2) levels have been associated with postoperative delirium in non-cardiac surgery patients.	Oxygen	26-32	synthesis of cytochrome C oxidase 2	Homo sapiens	45-49
22553653-1	2011	AIM: To observe the effect of erythropoietin receptor antibody (EpoRA) on oxygen-induced retinal neovascularization.	Oxygen	74-80	erythropoietin receptor	Mus musculus	30-53
31967857-2	2020	Three oxygen sensing enzyme complexes may be used for this purpose: 1) mitochondrial electron transport chain metabolism, 2) heme oxygenase 2 (HO-2) generating CO and/or 3) an NAD(P)H oxidase (NOX).	Oxygen	6-12	heme oxygenase 2	Mus musculus	143-147
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	28-34	vascular endothelial growth factor A	Rattus norvegicus	179-183
21738387-9	2011	Exposure to fluctuations of oxygen in the 50/10 oxygen-induced retinopathy model compared to RA was associated with increased PEDF mRNA (p=0.0185), PEDF protein (p&lt;0.0001), or VEGF protein (p&lt;0.0001).	Oxygen	48-54	vascular endothelial growth factor A	Rattus norvegicus	179-183
20157581-1	2009	Deficiency of the circadian clock protein BMAL1 leads to premature aging and increased levels of reactivate oxygen species in several tissues of mice.	Oxygen	108-114	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	42-47
32062149-6	2020	In the second catalytic stage, IrRu NPs in IrRu-GOx@PEG NPs catalyzed the upstream endogenous H2O2 to highly toxic singlet oxygen 1O2 and O2.	Oxygen	123-133	hydroxyacid oxidase 1, liver	Mus musculus	48-51
21738387-12	2011	CONCLUSIONS: Increased expression levels of VEGF and PEDF are associated with older postnatal day age or with exposure to fluctuations in oxygen in the 50/10 oxygen-induced retinopathy model compared to RA.	Oxygen	138-144	vascular endothelial growth factor A	Rattus norvegicus	44-48
21738387-12	2011	CONCLUSIONS: Increased expression levels of VEGF and PEDF are associated with older postnatal day age or with exposure to fluctuations in oxygen in the 50/10 oxygen-induced retinopathy model compared to RA.	Oxygen	158-164	vascular endothelial growth factor A	Rattus norvegicus	44-48
19955413-11	2009	Here, we report the unexpected observation that genetically diverse cancers converge at a common and obligatory growth axis instigated by HIF-2alpha, an element of the oxygen-sensing machinery.	Oxygen	168-174	endothelial PAS domain protein 1	Homo sapiens	138-148
32147668-1	2020	BACKGROUND: Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation through inducing mitochondrial fusion and altering oxygen consumption.	Oxygen	231-237	dynamin 1 like	Homo sapiens	137-141
20010384-2	2009	: An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation effect of a reporter or therapeutic gene expression by an oxygen-dependent degradation (ODD) domain in a hypoxia-inducible gene expression system with or without the erythropoietin (EPO) enhancer.	Oxygen	167-173	erythropoietin	Rattus norvegicus	275-289
20010384-2	2009	: An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation effect of a reporter or therapeutic gene expression by an oxygen-dependent degradation (ODD) domain in a hypoxia-inducible gene expression system with or without the erythropoietin (EPO) enhancer.	Oxygen	167-173	erythropoietin	Rattus norvegicus	291-294
19855262-3	2009	BACKGROUND: HIF-1alpha is a biologic O2 sensor enabling adaptation to hypoxia.	Oxygen	37-39	hypoxia inducible factor 1, alpha subunit	Mus musculus	12-22
21811636-8	2011	Thus, as well as demonstrating the potential of dietary tamoxifen administration for gene inactivation studies in UBC-Cre-ER(T2) mouse lines, this data provides evidence of a cardiac oxygen-sensing VHL/HIF/EPO pathway in adult mice.	Oxygen	183-189	erythropoietin	Mus musculus	206-209
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	ribosomal protein S6 kinase B1	Homo sapiens	160-163
21124131-4	2010	The partial pressure of oxygen in adipose tissue was measured with an oxygen monitor, and ischemic changes were analyzed by whole-mount staining, immunohistochemistry, flow cytometry, and Western blotting.	Oxygen	24-30	WD and tetratricopeptide repeats 1	Mus musculus	34-41
21124131-6	2010	RESULTS: Models for three degrees (mild, intermediate, and severe) of ischemia showed approximately 75, 55, and 20 percent of the partial pressure of oxygen level in normal adipose tissue (50.5+-1.3 mm Hg), respectively.	Oxygen	150-156	WD and tetratricopeptide repeats 1	Mus musculus	173-180
20193435-0	2009	[TERT-siRNA inhibits oxygen-induced retinal neovascularization in mice].	Oxygen	21-27	telomerase reverse transcriptase	Mus musculus	1-5
32037659-7	2020	Additionally, SGLT2 inhibitors induce a transcriptional paradigm that mimics nutrient and oxygen deprivation, which includes activation of adenosine monophosphate-activated protein kinase, sirtuin-1, and/or hypoxia-inducible factors-1alpha/2alpha.	Oxygen	90-96	solute carrier family 5 member 2	Homo sapiens	14-19
20359129-8	2009	Quantitative proteomic analysis showed increased ratios of plasma proteins (such as albumin) and oxygen carriers (such as myoglobin) by Ad-VEGF and decreased ratios of proteins involved in glycolysis, calcium homeostasis and lipolysis by Ad-VEGF.	Oxygen	97-103	vascular endothelial growth factor A	Rattus norvegicus	139-143
26045628-12	2010	In gas phase, COb shifts towards Fed to compensate for the electron density donated to oxygen upon the elimination of H2O.	Oxygen	87-93	metabolism of cobalamin associated B	Homo sapiens	14-17
32125470-6	2020	Immunohistochemical stainings of NeuN, MAP2, GFAP, and IBA1 revealed a neuroprotective potency of post-ROSC ventilation with 21% O2, although it was only temporary.	Oxygen	129-131	allograft inflammatory factor 1	Rattus norvegicus	55-59
20886866-4	2010	The BChE mutants with at least ~1000-fold improved catalytic efficiency against (-)-cocaine compared to the wild-type BChE are all associated with the TS1 structures having stronger overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of the enzyme.	Oxygen	228-234	butyrylcholinesterase	Homo sapiens	4-8
31134474-1	2020	Near infrared spectroscopy (NIRS) has been used to evaluate regional cerebral tissue oxygen saturation (ScO2) during the last decades.	Oxygen	85-91	synthesis of cytochrome C oxidase 2	Homo sapiens	104-108
20886866-4	2010	The BChE mutants with at least ~1000-fold improved catalytic efficiency against (-)-cocaine compared to the wild-type BChE are all associated with the TS1 structures having stronger overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of the enzyme.	Oxygen	228-234	butyrylcholinesterase	Homo sapiens	118-122
20961401-13	2010	We hypothesize that the fusion of the three chordate linkage groups 3, 15 and 17 more than 800 MYA led to the ancestral vertebrate globin cluster during a geological period of increased atmospheric oxygen content.	Oxygen	198-204	globin	Ciona intestinalis	131-137
19406206-3	2009	Redox cycling of reduced metabolites of these selenium compounds including selenide with oxygen via TrxR and reduced thioredoxin (Trx) will oxidize NADPH and produce reactive oxygen species inducing cell death at high concentrations explaining selenite toxicity.	Oxygen	89-95	thioredoxin	Homo sapiens	100-103
19797715-6	2009	In univariate analyses, mixed venous UII concentrations were correlated with diagnosis of acute coronary syndrome and femoral artery oxygen tension and inversely with systolic blood pressure and body mass index.	Oxygen	133-139	urotensin 2	Homo sapiens	37-40
32244628-7	2020	Furthermore, myocardial oxygen volume and double product were only significantly increased immediately after and 5 min post-exercise, while the heart rate was significantly elevated after the resistance training but decreased to baseline level by 50 min after training for both training conditions.	Oxygen	24-30	solute carrier family 35 member G1	Homo sapiens	119-123
19641936-6	2009	Exposure to 1% O2 or treatment with the hypoxia-mimetic agent cobalt chloride (CoCl2) significantly suppressed the expression of MSR1 mRNA, accompanied by a markedly increase in levels of nuclear HIF-1alpha protein.	Oxygen	15-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-206
32169478-3	2020	CtBPs are oxygen sensing molecules, and we have previously demonstrated an important role for CtBP1 in integrating oxygen levels and BMP-signaling to influence neural progenitor fate choice.	Oxygen	115-121	C-terminal binding protein 1	Mus musculus	94-99
19698203-7	2009	Increased glucose transport into adipocytes is also observed with low O2 tension, largely as a result of the up-regulation of GLUT-1 expression, indicating changes in cellular glucose metabolism.	Oxygen	70-72	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	126-132
20828702-3	2010	Based on the chromatographic behaviors for the resolution of PPI analogues on CSP 1, a chiral recognition mechanism utilizing the sulfoxide oxygen and the benzimidazole ring nitrogen of PPIs as bidentate coordination donors to form an enantioselective ternary complex with the central Cu(II) ion and the chiral stationary bidentate ligand was proposed.	Oxygen	140-146	regulator of calcineurin 1	Homo sapiens	78-83
20889127-4	2010	miR-378(*) performs this function by inhibiting the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in tricarboxylic acid cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation.	Oxygen	181-187	microRNA 378a	Homo sapiens	0-7
32234165-9	2020	Levels of cardiac reactive oxygen species was both elevated in wild-type burn group and MHC-ATGL burn group [(1.89+-0.23) vs (1.00+-0.18) and (1.38+-0.17) vs (0.95+-0.13)] (both P<0.001), while levels of cardiac reactive oxygen was reduction in MHC-ATGL burn group compared with wild-type burn group (P<0.001).	Oxygen	27-33	patatin-like phospholipase domain containing 2	Mus musculus	92-96
20889127-4	2010	miR-378(*) performs this function by inhibiting the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in tricarboxylic acid cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation.	Oxygen	181-187	GA binding protein transcription factor subunit alpha	Homo sapiens	103-108
19743846-0	2009	Hyperthermal O-atom exchange reaction O2 + CO2 through a CO4 intermediate.	Oxygen	38-40	complement C4A (Rodgers blood group)	Homo sapiens	57-60
32234165-9	2020	Levels of cardiac reactive oxygen species was both elevated in wild-type burn group and MHC-ATGL burn group [(1.89+-0.23) vs (1.00+-0.18) and (1.38+-0.17) vs (0.95+-0.13)] (both P<0.001), while levels of cardiac reactive oxygen was reduction in MHC-ATGL burn group compared with wild-type burn group (P<0.001).	Oxygen	27-33	patatin-like phospholipase domain containing 2	Mus musculus	249-253
19845613-3	2009	Several enzyme-linked oxygen sensing systems have been proposed, including nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent production of hydrogen peroxide, hemoxygenase-dependent generation of carbon monoxide, adenosine monophosphate (AMP) kinase-dependent channel phosphorylation, and src-Lck protein tyrosine kinase, via a currently undetermined mechanism.	Oxygen	22-28	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	312-315
19845614-6	2009	We discuss here the role in CB oxygen sensing of the hypoxia-inducible factor 1alpha, the mitochondrial complex II subunit D, and heme oxygenase 2.	Oxygen	31-37	hypoxia inducible factor 1, alpha subunit	Mus musculus	53-84
19845614-6	2009	We discuss here the role in CB oxygen sensing of the hypoxia-inducible factor 1alpha, the mitochondrial complex II subunit D, and heme oxygenase 2.	Oxygen	31-37	heme oxygenase 2	Mus musculus	90-146
21280568-2	2010	About half of the total O2 consumption in such mitochondria was found to be sensitive to salicylhydroxamate (SHAM), a known inhibitor of AOX activity.	Oxygen	24-26	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	137-140
21280568-3	2010	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive O2 consumption by nearly half, and addition at the end of the reaction released half of the O2 consumed by AOX, both typical of catalase action on H2O2.	Oxygen	109-111	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	48-51
21280568-3	2010	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive O2 consumption by nearly half, and addition at the end of the reaction released half of the O2 consumed by AOX, both typical of catalase action on H2O2.	Oxygen	201-203	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	216-219
21280568-4	2010	This reaffirmed that the product of reduction of O2 by plant AOX was H2O2 as found earlier and not H2O as reported in some recent reviews.	Oxygen	49-51	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	61-64
23074590-6	2010	RESULTS: An abnormal baseline rSBP after exercise was a strong predictor of exercise parameters in the last session, including metabolic equivalents (beta = -0.617, SE = 0.127, p value &lt; 0.001) and peak O2 consumption (beta = -1.950, SE = 0.363, p value &lt; 0.001) measured in the last session adjusted for baseline exercise characteristics, demographics, function class, and left ventricular ejection fraction.	Oxygen	206-208	spermine binding protein	Rattus norvegicus	30-34
19845617-1	2009	Using mice, we demonstrated that when oxygen supply is lowered, erythropoietin (Epo), the main regulator of red blood cell production, modulates the ventilatory response by interacting with central (brainstem) and peripheral (carotid bodies) respiratory centers.	Oxygen	38-44	erythropoietin	Mus musculus	64-78
19845617-1	2009	Using mice, we demonstrated that when oxygen supply is lowered, erythropoietin (Epo), the main regulator of red blood cell production, modulates the ventilatory response by interacting with central (brainstem) and peripheral (carotid bodies) respiratory centers.	Oxygen	38-44	erythropoietin	Mus musculus	80-83
32234165-9	2020	Levels of cardiac reactive oxygen species was both elevated in wild-type burn group and MHC-ATGL burn group [(1.89+-0.23) vs (1.00+-0.18) and (1.38+-0.17) vs (0.95+-0.13)] (both P<0.001), while levels of cardiac reactive oxygen was reduction in MHC-ATGL burn group compared with wild-type burn group (P<0.001).	Oxygen	221-227	patatin-like phospholipase domain containing 2	Mus musculus	92-96
20852629-10	2010	O2 availability, therefore, may have a direct role in stem cell regulation through HIF-1alpha modulation of Wnt/beta-catenin signalling.	Oxygen	0-2	catenin beta 1	Homo sapiens	112-124
31915282-4	2020	Besides, TRX2 inhibits the formation of VISA aggregates by repressing reactive oxygen species (ROS) production, thereby disrupting the assembly of VISA complex.	Oxygen	79-85	thioredoxin 2	Homo sapiens	9-13
19707690-1	2009	Complexation of iron(II) protoporphyrin IX (Fe(2+)PP) into a genetically engineered heme pocket on recombinant human serum albumin (rHSA) creates an artificial hemoprotein which can bind O(2) reversibly at room temperature.	Oxygen	187-191	CD24 molecule	Rattus norvegicus	132-136
21089678-6	2010	cTnT in the sham-operation group was significantly lower by comparison with that in the model group (P &lt; 0.01), and it was slightly lower in the oxygen carriers group than that in the model group, but there was no statistically significant difference (P = 0.18); MIS was significantly smaller in the sham-operation group than that in the model group (P &lt; 0.01), and it was greater in the model rats than that in the oxygen carriers rats (P &lt; 0.05).	Oxygen	148-154	troponin T2, cardiac type	Rattus norvegicus	0-4
31915282-4	2020	Besides, TRX2 inhibits the formation of VISA aggregates by repressing reactive oxygen species (ROS) production, thereby disrupting the assembly of VISA complex.	Oxygen	79-85	mitochondrial antiviral signaling protein	Homo sapiens	40-44
21089678-6	2010	cTnT in the sham-operation group was significantly lower by comparison with that in the model group (P &lt; 0.01), and it was slightly lower in the oxygen carriers group than that in the model group, but there was no statistically significant difference (P = 0.18); MIS was significantly smaller in the sham-operation group than that in the model group (P &lt; 0.01), and it was greater in the model rats than that in the oxygen carriers rats (P &lt; 0.05).	Oxygen	422-428	troponin T2, cardiac type	Rattus norvegicus	0-4
19712775-2	2009	They found that both molecules were built from Linus Pauling"s alpha helices, but folded and packed together in a complicated manner that never could have been deciphered by any other technique.With structure information in hand they could then explain how haemoglobin in the bloodstream binds and releases oxygen on cue, how it passes its cargo on to the related storage protein myoglobin, and how a single amino acid mutation can produce the catastrophe known as sickle-cell anemia.	Oxygen	307-313	myoglobin	Homo sapiens	380-389
31813956-10	2020	Finally, we demonstrate a gene-environment interaction in mouse embryos between Notch1 heterozygosity and low oxygen- or anti-arrhythmic drug-induced gestational hypoxia, resulting in an increased incidence of heart defects.	Oxygen	110-116	notch 1	Mus musculus	80-86
20687613-4	2010	Stopped-flow absorbance analyses of the reaction of the TrpH.Fe(II).6MePH(4).tryptophan complex with oxygen are consistent with the initial step being reversible binding of oxygen, followed by the formation with a rate constant of 65 s(-1) of an intermediate I that has maximal absorbance at 420 nm.	Oxygen	101-107	tryptophan hydroxylase 1	Homo sapiens	56-60
19690266-2	2009	The ScO2 measured by the NIRO 300 spectrometer (Hamamatsu Photonics, Japan) is called the cerebral tissue oxygenation index (TOI) and is an assessment of the balance between cerebral oxygen delivery and utilization.	Oxygen	106-112	synthesis of cytochrome C oxidase 2	Homo sapiens	4-8
20687613-4	2010	Stopped-flow absorbance analyses of the reaction of the TrpH.Fe(II).6MePH(4).tryptophan complex with oxygen are consistent with the initial step being reversible binding of oxygen, followed by the formation with a rate constant of 65 s(-1) of an intermediate I that has maximal absorbance at 420 nm.	Oxygen	173-179	tryptophan hydroxylase 1	Homo sapiens	56-60
32164721-1	2020	BACKGROUND: Na+/Ca2+ exchanger isoform 3 (NCX3) regulates mitochondrial Ca2+ handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD).	Oxygen	171-177	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	12-40
20712326-3	2010	When the linear polyperoxide obtained from methyl sorbate and oxygen (PP-MS) was used as a pressure-sensitive adhesive (PSA), its shear holding power and 180  peel strength immediately decreased upon heating at 70  C or under UV irradiation.	Oxygen	62-68	aminopeptidase puromycin sensitive	Homo sapiens	120-123
20592263-1	2010	The three Drosophila atypical soluble guanylyl cyclases, Gyc-89Da, Gyc-89Db, and Gyc-88E, have been proposed to act as oxygen detectors mediating behavioral responses to hypoxia.	Oxygen	119-125	Guanylyl cyclase at 89Db	Drosophila melanogaster	67-75
19502505-8	2009	Interferon-alpha-treated animals also showed a larger decrease of plasma glucose and greater values of NEFA, beta-hydroxybutyrate, and reactive oxygen metabolites.	Oxygen	144-150	INFA	Bos taurus	0-16
19343277-3	2009	The purpose of the current study is to investigate the role of PGC-1alpha in the oxygen (anoxia) deprivation (OGD) neurons.	Oxygen	81-87	PPARG coactivator 1 alpha	Sus scrofa	63-73
32164721-1	2020	BACKGROUND: Na+/Ca2+ exchanger isoform 3 (NCX3) regulates mitochondrial Ca2+ handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD).	Oxygen	171-177	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	42-46
20547419-3	2010	Lowest oxygen levels of 19 microM at 3 degrees N in the euphotic zone indicate mixing of low oxygen high salinity Arabian Sea waters with the equatorial Indian Ocean.	Oxygen	7-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	122-125
32182953-0	2020	Molecular and Pharmacological Modulation of CALHM1 Promote Neuroprotection against Oxygen and Glucose Deprivation in a Model of Hippocampal Slices.	Oxygen	83-89	calcium homeostasis modulator 1	Mus musculus	44-50
21061603-2	2010	The concentration of O2-, H2O2, and activity of oxidoreductases (oxalate oxidase, peroxidase, and catalase) depends on the content of Ca2+ ions in the culture medium of calluses.	Oxygen	21-23	peroxidase-like	Triticum aestivum	82-92
19399589-8	2009	We find that, in human airway cells exposed to hypoxia (3% oxygen), membrane-bound NDPK is inhibited.	Oxygen	59-65	cytidine/uridine monophosphate kinase 2	Homo sapiens	83-87
21475898-6	2009	In the present study, Egr-1 regulation was examined in the human glioblastoma cell lines U373, U251, GaMG and U87-MG under extreme hypoxic aeration conditions (0.1% O2) for 1, 6 and 24 h, 24-h extreme hypoxia with reoxygenation for 24 and 48 h, respectively, as well as oxygenated conditions (21% O2 and 5% CO2) in vitro.	Oxygen	165-167	early growth response 1	Homo sapiens	22-27
21061603-2	2010	The concentration of O2-, H2O2, and activity of oxidoreductases (oxalate oxidase, peroxidase, and catalase) depends on the content of Ca2+ ions in the culture medium of calluses.	Oxygen	21-23	catalase-1	Triticum aestivum	98-106
21475898-6	2009	In the present study, Egr-1 regulation was examined in the human glioblastoma cell lines U373, U251, GaMG and U87-MG under extreme hypoxic aeration conditions (0.1% O2) for 1, 6 and 24 h, 24-h extreme hypoxia with reoxygenation for 24 and 48 h, respectively, as well as oxygenated conditions (21% O2 and 5% CO2) in vitro.	Oxygen	297-299	early growth response 1	Homo sapiens	22-27
32043855-2	2020	NCM is also a promising electrocatalyst for the oxygen evolution reaction (OER), and the catalytic activity is highly correlated to its structure.	Oxygen	48-54	CWC22 spliceosome associated protein homolog	Homo sapiens	0-3
31935431-1	2020	Neuroprotective effects of leptin have been shown in mouse model of cerebral ischemia/reperfusion injury and primary cortical neuronal culture with oxygen-glucose deprivation (OGD), while the underlying mechanisms are less understood.	Oxygen	148-154	leptin	Mus musculus	27-33
19706422-0	2009	Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center.	Oxygen	89-91	deoxyhypusine hydroxylase	Homo sapiens	6-31
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Oxygen	78-84	deoxyhypusine hydroxylase	Homo sapiens	18-43
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Oxygen	78-84	deoxyhypusine hydroxylase	Homo sapiens	45-50
19706422-4	2009	Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable.	Oxygen	161-163	deoxyhypusine hydroxylase	Homo sapiens	187-192
19706422-6	2009	Despite a lack of sequence similarity, hDOHH has a nonheme diiron active site that resembles both in structure and function those found in methane and toluene monooxygenases, bacterial and mammalian ribonucleotide reductases, and stearoyl acyl carrier protein Delta9-desaturase from plants, suggesting that the oxygen-activating diiron motif is a solution arrived at by convergent evolution.	Oxygen	163-169	deoxyhypusine hydroxylase	Homo sapiens	39-44
20716364-5	2010	EF1alpha and RPL13a were validated for RT-qPCR analysis of MIAMI cells during expansion in varied oxygen tensions, endothelial differentiation, neural precursor enrichment, and during the comparison with RS-1 cells and commercially available MSC.	Oxygen	98-104	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	0-8
20506230-4	2010	One aspect of BAL design that must be considered is the mass transfer of adequate oxygen to the hepatocytes within the device.	Oxygen	82-88	poly(ADP-ribose) polymerase family member 9	Homo sapiens	14-17
20506230-5	2010	We present here a mathematical modeling approach to oxygen mass transport in a BAL.	Oxygen	52-58	poly(ADP-ribose) polymerase family member 9	Homo sapiens	79-82
31944416-1	2020	The HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1alpha and HIF-2alpha.	Oxygen	58-64	endothelial PAS domain protein 1	Homo sapiens	156-166
20675540-1	2010	Myoglobin, a mobile carrier of oxygen, is without a doubt an important player central to the physiological function of heart and skeletal muscle.	Oxygen	31-37	myoglobin	Homo sapiens	0-9
20675540-6	2010	This article reviews the current evidence underlying the evaluation of the biophysical parameters of myoglobin-facilitated oxygen diffusion in cells, specifically the intracellular concentration of myoglobin, the intracellular diffusion coefficient of myoglobin and the intracellular myoglobin oxygen saturation.	Oxygen	123-129	myoglobin	Homo sapiens	101-110
20675540-6	2010	This article reviews the current evidence underlying the evaluation of the biophysical parameters of myoglobin-facilitated oxygen diffusion in cells, specifically the intracellular concentration of myoglobin, the intracellular diffusion coefficient of myoglobin and the intracellular myoglobin oxygen saturation.	Oxygen	294-300	myoglobin	Homo sapiens	101-110
21577535-1	2009	In the enanti-omerically pure title compound, C(11)H(19)N(3)O(3)S, the chain C-N-C(O)-O-C-C (from the asymmetric carbon to a methyl of the tert-butyl group) displays an extended conformation.	Oxygen	83-87	telomerase reverse transcriptase	Homo sapiens	139-143
19644138-7	2009	CONCLUSIONS: The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes.	Oxygen	95-101	serpin family B member 3	Homo sapiens	64-67
19664386-8	2009	AGES-HSA-induced PAI-1 expression were significantly suppressed by the NAD(P)H oxidase inhibitors DPI, apocynin or O2- scavenger SOD.	Oxygen	115-117	serpin family E member 1	Homo sapiens	17-22
20675540-7	2010	The review considers the role of myoglobin in oxygen transport in vertebrate heart and skeletal muscle, in the diving seal during apnea as well as the role of the analogous leghemoglobin of plants.	Oxygen	46-52	myoglobin	Homo sapiens	33-42
20701790-9	2010	Neurons treated with either globular or trimeric adiponectin exhibited increased vulnerability to oxygen and glucose deprivation which was associated with increased activation of a pro-apoptotic signaling cascade involving p38 mitogen-activated protein kinase (p38MAPK) and AMP-activated protein kinase (AMPK).	Oxygen	98-104	adiponectin, C1Q and collagen domain containing	Mus musculus	49-60
31932812-7	2020	Through activation of EGR1, excessive reactive oxygen species in the tumor microenvironment induce expression of PAC1, which recruits the Mi-2beta nucleosome-remodeling and histone-deacetylase complex, eventually leading to chromatin remodeling of effector T cells.	Oxygen	47-53	early growth response 1	Homo sapiens	22-26
20697002-1	2010	OBJECTIVE: To study the effects of oxygen fluctuations on rat vascular endothelial growth factor (VEGF), VEGF receptor 1(VEGFR1), and VEGFR2 in a model of retinopathy of prematurity (ROP).	Oxygen	35-41	vascular endothelial growth factor A	Rattus norvegicus	62-96
19625515-6	2009	Furthermore, we propose a pathogenetic mechanism in which respiratory chain dysfunction and increased reactive oxygen species production caused by Afg3l2 haploinsufficiency lead to dark degeneration of Purkinje cells and cerebellar dysfunction.	Oxygen	111-117	AFG3 like matrix AAA peptidase subunit 2	Homo sapiens	147-153
31894498-10	2020	Additionally, two buried residues located in close proximity to A1B (PsaB:712H and 714S) were modified, which appears consistent with A1B being a source of O2.-.	Oxygen	156-158	PSI P700 apoprotein A2	Spinacia oleracea	69-73
19499902-4	2009	In the six ionic liquids, the Stokes-Einstein relationship (D proportional, variant eta(-1)) was found to apply only very approximately for oxygen.	Oxygen	140-146	secreted phosphoprotein 1	Homo sapiens	84-91
20560877-0	2010	Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation.	Oxygen	93-99	leptin	Homo sapiens	0-6
20560877-1	2010	Molecular mechanism underlying leptin-mediated neuronal protection against glucose-oxygen-serum deprivation (GOSD) insult was investigated by focusing on the interactions among leptin, Interleukin-1beta (IL-1beta) and glutamate and their impacts on the growth of neurons under GOSD.	Oxygen	83-89	leptin	Homo sapiens	31-37
19798981-1	2009	Myoglobin (Mb) made up of a multipeptides train and a heme prosthetic group is a kind of protein taking charge of O2 stock and distribution in mammal cells, especially in muscle cells.	Oxygen	114-116	myoglobin	Homo sapiens	0-9
31833100-3	2020	Moreover, the SERS activity keeps stable upon repeated oxygen insertion-extraction.	Oxygen	55-61	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	14-18
20651722-0	2010	Reversible dioxygen binding in solvent-free liquid myoglobin.	Oxygen	11-19	myoglobin	Homo sapiens	51-60
20651722-4	2010	Here we describe the synthesis and properties of room-temperature solvent-free myoglobin liquids with near-native structure and reversible dioxygen binding ability equivalent to the haem protein under physiological conditions.	Oxygen	139-147	myoglobin	Homo sapiens	79-88
19488048-7	2009	NPY and AgRP increased feeding and decreased oxygen consumption, with the effects of AgRP being more prolonged.	Oxygen	45-51	agouti related neuropeptide	Rattus norvegicus	8-12
32079227-2	2020	It is also stabilized under hypoxic conditions when it regulates the accumulation of the transcription factor HIF (Hypoxia Inducible Factor)-1alpha, which activates the transcription of target genes to orchestrate a cellular response to low oxygen.	Oxygen	241-247	hypoxia inducible factor 1, alpha subunit	Mus musculus	115-147
20668552-7	2010	The bcl-2-induced HIF-1alpha stabilization in response to low oxygen tension conditions was achieved through the impairment of ubiquitin-dependent HIF-1alpha degradation involving the molecular chaperone HSP90, but it was not dependent on the prolyl hydroxylation of HIF-1alpha protein.	Oxygen	62-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	204-209
20616029-7	2010	Activation of AMPK and SIRT1 by FGF21 in adipocytes enhanced mitochondrial oxidative capacity as demonstrated by increases in oxygen consumption, citrate synthase activity, and induction of key metabolic genes.	Oxygen	126-132	sirtuin 1	Mus musculus	23-28
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	sirtuin 1	Mus musculus	20-25
19264880-7	2009	CONCLUSIONS: Activation of NADPH oxidase from supplemental oxygen works through activated STAT3 to lead to IVNV.	Oxygen	59-65	signal transducer and activator of transcription 3	Rattus norvegicus	90-95
32057147-0	2020	Bifunctional Catalysts for Reversible Oxygen Evolution Reaction and Oxygen Reduction Reaction: Mix Better.	Oxygen	38-44	Mix paired-like homeobox	Homo sapiens	95-98
19328848-5	2009	OH-Cbl and CN(2)-Cbi prevented binding of the oxygen analog carbon monoxide (CO) to the reduced NOS1 and NOS2 heme active site.	Oxygen	46-52	Casitas B-lineage lymphoma	Mus musculus	3-6
20124401-0	2010	Significance of myoglobin as an oxygen store and oxygen transporter in the intermittently perfused human heart: a model study.	Oxygen	32-38	myoglobin	Homo sapiens	16-25
20124401-1	2010	AIMS: The mechanisms by which the left ventricular wall escapes anoxia during the systolic phase of low blood perfusion are investigated, especially the role of myoglobin (Mb), which can (i) store oxygen and (ii) facilitate intracellular oxygen transport.	Oxygen	197-203	myoglobin	Homo sapiens	161-170
20124401-1	2010	AIMS: The mechanisms by which the left ventricular wall escapes anoxia during the systolic phase of low blood perfusion are investigated, especially the role of myoglobin (Mb), which can (i) store oxygen and (ii) facilitate intracellular oxygen transport.	Oxygen	197-203	myoglobin	Homo sapiens	172-174
20124401-1	2010	AIMS: The mechanisms by which the left ventricular wall escapes anoxia during the systolic phase of low blood perfusion are investigated, especially the role of myoglobin (Mb), which can (i) store oxygen and (ii) facilitate intracellular oxygen transport.	Oxygen	238-244	myoglobin	Homo sapiens	172-174
20124401-5	2010	The basic model assumption is that, with mobile Mb, the oxygen stored in the end-diastolic left ventricle wall exactly meets the demand during the 150 ms of systolic cessation of blood flow.	Oxygen	56-62	myoglobin	Homo sapiens	48-50
32057147-0	2020	Bifunctional Catalysts for Reversible Oxygen Evolution Reaction and Oxygen Reduction Reaction: Mix Better.	Oxygen	68-74	Mix paired-like homeobox	Homo sapiens	95-98
20124401-7	2010	By considering Mb immobile or setting its concentration to zero, respectively, we find that, depending on Mb concentration, Mb-facilitated O(2) transport maintains O(2) supply to the left ventricle wall during 22-34 of the 150 ms, while Mb storage function accounts for a further 12-17 ms.	Oxygen	139-143	myoglobin	Homo sapiens	15-17
20124401-7	2010	By considering Mb immobile or setting its concentration to zero, respectively, we find that, depending on Mb concentration, Mb-facilitated O(2) transport maintains O(2) supply to the left ventricle wall during 22-34 of the 150 ms, while Mb storage function accounts for a further 12-17 ms.	Oxygen	139-143	myoglobin	Homo sapiens	106-108
20124401-7	2010	By considering Mb immobile or setting its concentration to zero, respectively, we find that, depending on Mb concentration, Mb-facilitated O(2) transport maintains O(2) supply to the left ventricle wall during 22-34 of the 150 ms, while Mb storage function accounts for a further 12-17 ms.	Oxygen	139-143	myoglobin	Homo sapiens	106-108
20124401-7	2010	By considering Mb immobile or setting its concentration to zero, respectively, we find that, depending on Mb concentration, Mb-facilitated O(2) transport maintains O(2) supply to the left ventricle wall during 22-34 of the 150 ms, while Mb storage function accounts for a further 12-17 ms.	Oxygen	139-143	myoglobin	Homo sapiens	106-108
20124401-9	2010	CONCLUSION: While Mb plays no significant role during diastole, it supplies O(2) to the left ventricular wall for &lt; or = 50 ms of the 150 ms systole, whereas capillary haemoglobin is responsible for approximately 80 ms.	Oxygen	76-80	myoglobin	Homo sapiens	18-20
19043457-6	2009	The maximum CLA+ T-cell percentage was significantly correlated with a high body temperature, low percutaneous oxygen saturation, and fibrinogen/fibrin degradation product D-dimer level.	Oxygen	111-117	selectin P ligand	Homo sapiens	12-15
19299574-2	2009	Furthermore, despite weighing 14% less, 7th generation HCR rats achieved the same absolute maximal oxygen consumption (Vo(2max)) as LCR due to muscle adaptations that improved oxygen extraction and use.	Oxygen	99-105	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	55-58
19299574-2	2009	Furthermore, despite weighing 14% less, 7th generation HCR rats achieved the same absolute maximal oxygen consumption (Vo(2max)) as LCR due to muscle adaptations that improved oxygen extraction and use.	Oxygen	176-182	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	55-58
19370813-6	2009	The developed models suggest that the distribution of charges on the phenolic nucleus and the phenolic oxygen as well as the charged surface areas of the molecules together with the geometry and orientation of the substituents significantly influence all the three types of responses (pC1, pC2 and pC3).	Oxygen	103-109	proprotein convertase subtilisin/kexin type 1	Homo sapiens	285-288
20821977-0	2010	[Effect of erythropoietin on blood oxygen transport in rats during cold exposure and subsequent rewarming].	Oxygen	35-41	erythropoietin	Rattus norvegicus	11-25
32028649-1	2020	D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids generating hydrogen peroxide, a potential producer of reactive oxygen species.	Oxygen	132-138	D-amino acid oxidase	Homo sapiens	0-20
20821977-3	2010	The effect of EPO in tested rats is associated with a decrease in the hemoglobin affinity to oxygen, which increases the oxygen supply of tissues and improves the organism adaptability to cold.	Oxygen	93-99	erythropoietin	Rattus norvegicus	14-17
20821977-3	2010	The effect of EPO in tested rats is associated with a decrease in the hemoglobin affinity to oxygen, which increases the oxygen supply of tissues and improves the organism adaptability to cold.	Oxygen	121-127	erythropoietin	Rattus norvegicus	14-17
19281193-2	2009	Two ligands chelate the metal through their ortho oxygen (O1, O2) moiety while two para oxygens, from other Lap ligands, complete the octahedral coordination sphere.	Oxygen	88-95	LAP	Homo sapiens	108-111
19281193-3	2009	Thus far, all reported Lap metal complexes are mononuclear, lack the metal-trans-quinonic (para) oxygen binding and have Lap as a bidentate ligand.	Oxygen	97-103	LAP	Homo sapiens	23-26
32028649-1	2020	D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids generating hydrogen peroxide, a potential producer of reactive oxygen species.	Oxygen	132-138	D-amino acid oxidase	Homo sapiens	22-26
20552645-7	2010	In this case, the coplanarity between the copper atom, the oxygen of the C-1 and the ring would only permit the oxidation/reduction of one copper atom, giving rise to copper (0), hydrogen peroxide, and an o-quinone, which would be released, thus inactivating the enzyme.	Oxygen	59-65	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	73-76
31750580-8	2020	RESULTS: Cytolysis of IL3-primed eosinophils was dependent on production of reactive oxygen species (ROS) and downstream phosphorylation of p-38 MAPK.	Oxygen	85-91	interleukin 3	Homo sapiens	22-25
20237132-2	2010	Because cysteine-rich 61 (CYR61, CCN1) and nephroblastoma overexpressed (NOV, CCN3) are expressed in the extravillous trophoblast and expression levels are deregulated in preeclampsia, we investigated their regulation properties in first-trimester placental explants and in JEG3 choriocarcinoma cells upon a physiological low oxygen tension of 1-3%.	Oxygen	326-332	cellular communication network factor 1	Homo sapiens	33-37
19359588-3	2009	Forced expression of mutant IDH1 in cultured cells reduces formation of the enzyme product, alpha-ketoglutarate (alpha-KG), and increases the levels of hypoxia-inducible factor subunit HIF-1alpha, a transcription factor that facilitates tumor growth when oxygen is low and whose stability is regulated by alpha-KG.	Oxygen	255-261	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
20237132-2	2010	Because cysteine-rich 61 (CYR61, CCN1) and nephroblastoma overexpressed (NOV, CCN3) are expressed in the extravillous trophoblast and expression levels are deregulated in preeclampsia, we investigated their regulation properties in first-trimester placental explants and in JEG3 choriocarcinoma cells upon a physiological low oxygen tension of 1-3%.	Oxygen	326-332	cellular communication network factor 3	Homo sapiens	78-82
31908054-9	2020	More importantly, overexpression of oxygen stable HIF1alpha reversed attenuated proinflammatory and glycolytic gene expression in KLF6-deficient macrophages.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	50-59
20237132-7	2010	These results indicate that low oxygen levels trigger elevation of intracellular as well as secreted CYR61 and NOV protein probably in two independent pathways.	Oxygen	32-38	cellular communication network factor 1	Homo sapiens	101-106
19222187-5	2009	In free wild-type or D374Y mutant PCSK9, the t1/2 for exchange of 18O for both oxygens was near 5 min.	Oxygen	79-86	proprotein convertase subtilisin/kexin type 9	Homo sapiens	34-39
19263049-7	2009	The expression levels of BAP2 (encoding the branched chain amino acid permease), ERG1 (encoding squalene epoxidase), and the stress responsive gene HSP12 were predominantly influenced by the high cell concentrations, while OLE1 (encoding the fatty acid desaturase) and the oxidative stress responsive genes SOD1 and CTT1 were mainly affected by the oxygen availability per cell.	Oxygen	349-355	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	25-29
31757716-9	2020	Additionally, the real-time extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) measurement also affirmed that PVT1 maintains glycolytic levels, glycolytic capacity under stress and ECAR/OCR ratios during T cell activation.	Oxygen	72-78	Pvt1 oncogene	Homo sapiens	133-137
19365031-0	2009	Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen.	Oxygen	95-101	protein kinase C, gamma	Mus musculus	8-29
19365031-1	2009	OBJECTIVE: To determine if loss of protein kinase Cgamma (PKCgamma) results in increased structural damage to the retina by hyperbaric oxygen (HBO), a treatment used for several ocular disorders.	Oxygen	135-141	protein kinase C, gamma	Mus musculus	35-56
19365031-1	2009	OBJECTIVE: To determine if loss of protein kinase Cgamma (PKCgamma) results in increased structural damage to the retina by hyperbaric oxygen (HBO), a treatment used for several ocular disorders.	Oxygen	135-141	protein kinase C, gamma	Mus musculus	58-66
19188096-4	2009	Mb in the {PEG/ZrO(2)}(n)-Mb films fabricated on pyrolytic graphite (PG) electrodes showed direct and quasi-reversible CV response, which could be used to electrocatalyze reduction of oxygen and hydrogen peroxide.	Oxygen	184-190	myoglobin	Homo sapiens	0-2
19188096-4	2009	Mb in the {PEG/ZrO(2)}(n)-Mb films fabricated on pyrolytic graphite (PG) electrodes showed direct and quasi-reversible CV response, which could be used to electrocatalyze reduction of oxygen and hydrogen peroxide.	Oxygen	184-190	myoglobin	Homo sapiens	26-28
20334467-0	2010	Attenuating experimental spinal cord injury by hyperbaric oxygen: stimulating production of vasculoendothelial and glial cell line-derived neurotrophic growth factors and interleukin-10.	Oxygen	58-64	interleukin 10	Rattus norvegicus	171-185
20307258-3	2010	Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and gave rise to an altered pattern of respiratory supercomplexes.	Oxygen	116-122	cytochrome c oxidase subunit 6A1	Homo sapiens	29-34
20507570-7	2010	We predict that at low oxygen the heterogeneity of a MSC population with respect to differentiation regenerates from any selected subpopulation in about two days.	Oxygen	23-29	musculin	Homo sapiens	53-56
20353155-0	2010	Formation of aminoxy and oxo complexes from the reaction of Nb(NMe2)5 with O2 and the crystal structure of Nb(NEt2)5.	Oxygen	75-77	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	63-67
20348304-2	2010	One of the best-studied systems involved in mediating the response to changes in environmental oxygen levels is the Arc two-component system of Escherichia coli, consisting of the sensor kinase ArcB and the cognate response regulator ArcA.	Oxygen	95-101	hypothetical protein	Escherichia coli	194-198
19275153-1	2009	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine.	Oxygen	106-110	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
19275153-1	2009	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine.	Oxygen	106-110	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
31531986-8	2020	Densitometric evaluation demonstrated a 39% (p &lt; 0.05) and 25% (p &lt; 0.05) increase in myogenin and actin protein levels, respectively, in the cells treated with 1 dose of hyperbaric oxygen.	Oxygen	188-194	myogenin	Mus musculus	92-100
19307731-4	2009	Here, we sought to determine how tumors without hypoxia would progress by engineering A549 human lung carcinoma cells to ectopically express myoglobin (Mb), a multifunctional heme protein that specializes in oxygen transport, storage, and buffering.	Oxygen	208-214	myoglobin	Homo sapiens	141-150
19307731-4	2009	Here, we sought to determine how tumors without hypoxia would progress by engineering A549 human lung carcinoma cells to ectopically express myoglobin (Mb), a multifunctional heme protein that specializes in oxygen transport, storage, and buffering.	Oxygen	208-214	myoglobin	Homo sapiens	152-154
19372575-3	2009	Siah2 regulates prolyl hydroxylases PHD3 and 1 under oxygen concentration of 2% to 5%, thereby allowing accumulation of hypoxia-inducible factor (HIF)-1alpha, a master regulator of the hypoxia response within the range of physiological normoxic to mild hypoxic conditions.	Oxygen	53-59	egl-9 family hypoxia-inducible factor 3	Mus musculus	36-46
19372575-3	2009	Siah2 regulates prolyl hydroxylases PHD3 and 1 under oxygen concentration of 2% to 5%, thereby allowing accumulation of hypoxia-inducible factor (HIF)-1alpha, a master regulator of the hypoxia response within the range of physiological normoxic to mild hypoxic conditions.	Oxygen	53-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	120-157
21033404-5	2010	An analytical expression was proposed to describe change in O2 consumption in the interval of altitudes from 0 to 4200 m above sea level.	Oxygen	60-62	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
20212266-13	2010	These results suggest that low tissue oxygen determines increased expression of the atrial SUR2A/B/Kir6.1 gene via activation of HIF-1alpha-FOXO1.	Oxygen	38-44	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	99-105
19372578-5	2009	As compared with 20%, growth at 7% oxygen resulted in an increase in the expression levels of the neural stem cell markers CD133 and nestin as well as the stem cell markers Oct4 and Sox2.	Oxygen	35-41	POU class 5 homeobox 1	Homo sapiens	173-177
31531986-9	2020	Similarly, the myogenin and actin protein levels increased for samples receiving multiple hyperbaric oxygen treatments when compared to the control.	Oxygen	101-107	myogenin	Mus musculus	15-23
31531986-11	2020	In conclusion, hyperbaric oxygen treatment increases the myoblast growth rate and myogenin and actin production.	Oxygen	26-32	myogenin	Mus musculus	82-90
24855550-3	2010	METHODS AND RESULTS: Using potent antagonists gamma-secretase inhibitor and cyclopamine, we inhibited Notch and Hh pathways, respectively, in the CLS1 hESC line expanded continuously in a hypoxic atmosphere of 5% oxygen.	Oxygen	213-219	cardiolipin synthase 1	Homo sapiens	146-150
31794162-7	2020	In the correlation analysis after adjusting for gestational age and sex, tPEF /tE was correlated with the duration of mechanical ventilation (r = -0.347, P < .001) and the duration of oxygen supply (r = -0.248, P = .013) in infants with BPD.	Oxygen	184-190	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	73-77
20412594-8	2010	Increased alpha-enolase mRNA and preferential translation/post-translational modification may also allow for acclimatization to low oxygen, particularly under low glucose concentrations.	Oxygen	132-138	enolase 1	Homo sapiens	10-23
18956135-6	2009	An increase in InTc to &gt;6 during 100% oxygen administration for the high PVR group indicated good PA reactivity with a sensitivity of 93%, specificity of 100%, and agreement of 95% (kappa = 0.83).	Oxygen	41-47	PVR cell adhesion molecule	Homo sapiens	76-79
19283836-12	2009	CONCLUSION: Multiple therapeutic BAL of children with LP results in significant improvement of CT findings, oxygen saturation, restoration of BAL fluid cellularity and clinical recover without any evidence of respiratory distress at the end of treatment and 6 months after the last BAL.	Oxygen	108-114	poly(ADP-ribose) polymerase family member 9	Homo sapiens	33-36
20118236-6	2010	Surprisingly, in spontaneously immortalized cell lines from both wild-type and Hupki MEFs, the predominant type of p53 mutation was a G to C transversion, rather than the G to T substitutions expected from the raised oxygen levels characteristic of standard culture conditions.	Oxygen	217-223	transformation related protein 53, pseudogene	Mus musculus	115-118
31759628-4	2020	This study aimed to evaluate the role of vascular endothelial growth factor-A (VEGFA)-PLVAP axis in the maintenance of choroidal fenestrations using oxygen-induced retinopathy (OIR) model.	Oxygen	149-155	plasmalemma vesicle associated protein	Mus musculus	86-91
20396382-10	2010	Low levels of leptin reconciled contractile, intracellular Ca2+ and cell signaling defects as well as O2(-) production and p(47phox) upregulation in young but not aging ob/ob mice.	Oxygen	102-104	leptin	Mus musculus	14-20
31993228-1	2020	Objectives: We sought to investigate and prove the effect of hyperbaric oxygen therapy (HBOT) on T helper 17 (Th17)/regulatory T (Treg) cell polarization through changes in the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) in rheumatoid arthritis (RA) animal model.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	191-223
20104488-0	2010	CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1.	Oxygen	58-64	sphingosine kinase 1	Homo sapiens	99-119
20040577-10	2010	The structural and functional data reported in this study support a role of the Tpa1 family as a hydroxylase in the mRNP complex and as an oxygen sensor.	Oxygen	139-145	oxidative DNA demethylase	Saccharomyces cerevisiae S288C	80-84
20008461-4	2010	Exposure to 4% oxygen induced ACC oxidase expression in these cell types as well as in the root cortex.	Oxygen	15-21	acc oxidase	Zea mays	30-41
19233725-8	2009	In parallel to significantly higher p selectin expression, treated PLTs exhibited significantly accelerated oxygen and glucose consumption rates associated with increased acidity due to higher lactate production rates throughout storage.	Oxygen	108-114	selectin P	Homo sapiens	36-46
19189049-1	2009	The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria.	Oxygen	143-149	PAS domain containing serine/threonine kinase	Mus musculus	22-28
19189049-1	2009	The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria.	Oxygen	143-149	PAS domain containing serine/threonine kinase	Mus musculus	42-52
19189049-1	2009	The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria.	Oxygen	143-149	PAS domain containing serine/threonine kinase	Mus musculus	22-26
19175415-4	2009	The gene expressions of both the important transcription factors Hap1 and Rox1, involved in oxygen sensing, were mainly increased in the first 3 h, while YAP1 expression, which is involved in the oxidative stress response, increased drastically only in the first 45 min.	Oxygen	92-98	Hap1p	Saccharomyces cerevisiae S288C	65-69
31993228-1	2020	Objectives: We sought to investigate and prove the effect of hyperbaric oxygen therapy (HBOT) on T helper 17 (Th17)/regulatory T (Treg) cell polarization through changes in the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) in rheumatoid arthritis (RA) animal model.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	225-235
31893500-0	2020	Probing the Local Generation and Diffusion of Active Oxygen Species on a Pd/Au Bimetallic Surface by Tip-Enhanced Raman Spectroscopy.	Oxygen	53-59	TOR signaling pathway regulator	Homo sapiens	101-104
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	reticulon 4	Homo sapiens	318-324
20066661-1	2010	Complexation of the oxygen atom in 2-butylphenylethers and sulfur in 2-butylphenylthioethers to a rhodium atom in dirhodium tetracarboxylate Rh((II)) (2)[(R)-(+)-MTPA](4) is compared.	Oxygen	20-26	Rh blood group D antigen	Homo sapiens	141-148
32038585-0	2019	Diversity of Bacterial Community in the Oxygen Minimum Zones of Arabian Sea and Bay of Bengal as Deduced by Illumina Sequencing.	Oxygen	40-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
19095301-5	2009	We have recently reported on the expression and function of two Bcl-2 family members in normal placental development, namely the pro-apoptotic Mtd/Bok, and its anti-apoptotic partner Mcl-1 and have found that their expression is upregulated by low oxygen, a key mediator of trophoblast cell proliferation in early placentation.	Oxygen	248-254	metallothionein 1E	Homo sapiens	143-146
19095301-5	2009	We have recently reported on the expression and function of two Bcl-2 family members in normal placental development, namely the pro-apoptotic Mtd/Bok, and its anti-apoptotic partner Mcl-1 and have found that their expression is upregulated by low oxygen, a key mediator of trophoblast cell proliferation in early placentation.	Oxygen	248-254	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	183-188
31959741-6	2020	NEDD4L-depleted cells exhibited an increase in the cellular oxygen consumption rate (OCR) and mitochondrial membrane potential, and maintained mitochondrial fusion status in response to metabolic stress.	Oxygen	60-66	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	0-6
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Oxygen	185-191	complement C2	Homo sapiens	99-102
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Oxygen	185-191	complement C2	Homo sapiens	211-214
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Oxygen	185-191	complement C2	Homo sapiens	211-214
31964803-0	2020	Genetic basis of oxygen sensing in the carotid body: HIF2alpha and an isoform switch in cytochrome c oxidase subunit 4.	Oxygen	17-23	endothelial PAS domain protein 1	Homo sapiens	53-62
31952230-7	2020	MVS-induced HO-1 expression was mediated via NADPH oxidase (Nox)-derived reactive oxygen species (ROS) generation.	Oxygen	82-88	heme oxygenase 1	Homo sapiens	12-16
19143764-6	2009	RESULTS: In contrast to culture at 21% oxygen, where the colonies displayed a marked degree of differentiation, we found that during exposure to 5% oxygen, the hESC colonies displayed a homogenous and flat morphology that was consistent with the presence of Oct4-positive phenotype, indicating no spontaneous differentiation.	Oxygen	148-154	POU class 5 homeobox 1	Homo sapiens	258-262
31998679-0	2019	One-Step Synthesis of N, P-Codoped Carbon Nanosheets Encapsulated CoP Particles for Highly Efficient Oxygen Evolution Reaction.	Oxygen	101-107	caspase recruitment domain family member 16	Homo sapiens	66-69
19148508-6	2009	Since HSC appear to be oxygen-sensing cells, the expression of E-selectin binding activity was analyzed in HSC under a hypoxic atmosphere.	Oxygen	23-29	selectin E	Homo sapiens	63-73
31789040-7	2020	Within these candidates, we confirmed the relationship between one of the candidates Nce103 and Hrt3, and linked the Hrt3 with oxygen sensitivity and oxidative stress response which Nce103 took part in as well.	Oxygen	127-133	SCF ubiquitin ligase complex subunit HRT3	Saccharomyces cerevisiae S288C	96-100
19061417-3	2009	Chymotrypsin digestion indicated that the rod (tail) subfragment of myosin was the preferred target of hydroxyl radicals and ferryl oxygen species, although the s-1 (head) region was also susceptible.	Oxygen	132-138	myosin heavy chain 14	Homo sapiens	68-74
31789040-7	2020	Within these candidates, we confirmed the relationship between one of the candidates Nce103 and Hrt3, and linked the Hrt3 with oxygen sensitivity and oxidative stress response which Nce103 took part in as well.	Oxygen	127-133	SCF ubiquitin ligase complex subunit HRT3	Saccharomyces cerevisiae S288C	117-121
19156806-0	2009	Proton pump for O2 reduction catalyzed by 5,10,15,20-tetraphenylporphyrinatocobalt(II).	Oxygen	16-18	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	0-11
19330530-4	2009	Immunofluorescence showed the incorporation and mixed growth of CD31-, Tie-2-, and CD105-positive endothelial cells in tumors with radii less than oxygen diffusion distance and subsequent development of blood vessels from these early-incorporated endothelial cells.	Oxygen	147-153	endoglin	Mus musculus	83-88
32138537-8	2020	The western blot and real-time PCR data revealed that hypoxic stress with 2.5% O2 suppressed the expression of miR-145 and Wnt3a/beta-catenin in cultured rat cardiomyocytes but augmented Dab2.	Oxygen	79-81	microRNA 145	Rattus norvegicus	111-118
19672068-8	2009	Furthermore, hyperoxia induced upregulation of MMP-9 following 12 h of oxygen exposure and this was attenuated by rEpo treatment.	Oxygen	71-77	erythropoietin	Rattus norvegicus	114-118
19672068-9	2009	Our results suggest that rEpo generates its protective effect against oxygen toxicity through a reduction of proinflammatory mediator levels.	Oxygen	70-76	erythropoietin	Rattus norvegicus	25-29
32138537-8	2020	The western blot and real-time PCR data revealed that hypoxic stress with 2.5% O2 suppressed the expression of miR-145 and Wnt3a/beta-catenin in cultured rat cardiomyocytes but augmented Dab2.	Oxygen	79-81	catenin beta 1	Rattus norvegicus	129-141
31885705-0	2020	Downregulated miRNA-324-5p aggravates neuronal injury induced by oxygen-glucose deprivation via modulating RAN.	Oxygen	65-79	RAN, member RAS oncogene family	Homo sapiens	107-110
19542619-4	2009	Examination of an in vitro model of cultured rat corticohippocampal neurons revealed that even relatively low level expression of human truncated tau protein (equal to 50% of endogenous tau) induced oxidative stress that resulted in increased depolarization of mitochondria (approximately 1.2-fold above control, P < 0.01) and increases in reactive oxygen species (approximately 1.3-fold above control, P < 0.001).	Oxygen	349-355	microtubule associated protein tau	Homo sapiens	146-149
19542619-6	2009	Furthermore, using two common antioxidants (vitamin C and E), we were able significantly eliminate tau-induced elevation of reactive oxygen species.	Oxygen	133-139	microtubule associated protein tau	Homo sapiens	99-102
31942176-12	2020	CBR1 inhibition increased levels of intracellular reactive oxygen species (ROS) in HNSCC cells leading to upregulation of beta-catenin, one of main transcription factors that induce EMT-related genes.	Oxygen	59-65	catenin beta 1	Homo sapiens	122-134
18781596-7	2009	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70(S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Oxygen	195-201	ribosomal protein S6 kinase B1	Homo sapiens	112-115
31670138-1	2020	Myoglobin (Mb) binds oxygen with high affinity as a low spin singlet complex and thus functions as an oxygen storage protein.	Oxygen	21-27	myoglobin	Homo sapiens	0-9
18832593-4	2009	Surprisingly, although HGG precursors generated endogenous bone morphogenetic protein (BMP) signaling that promoted mitotic arrest under high oxygen tension, this signaling was actively repressed by hypoxia.	Oxygen	142-148	bone morphogenetic protein 1	Homo sapiens	59-85
18832593-4	2009	Surprisingly, although HGG precursors generated endogenous bone morphogenetic protein (BMP) signaling that promoted mitotic arrest under high oxygen tension, this signaling was actively repressed by hypoxia.	Oxygen	142-148	bone morphogenetic protein 1	Homo sapiens	87-90
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	35-41	bone morphogenetic protein 1	Homo sapiens	12-15
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	35-41	bone morphogenetic protein 1	Homo sapiens	99-102
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	144-150	bone morphogenetic protein 1	Homo sapiens	12-15
31670138-1	2020	Myoglobin (Mb) binds oxygen with high affinity as a low spin singlet complex and thus functions as an oxygen storage protein.	Oxygen	102-108	myoglobin	Homo sapiens	0-9
18832593-8	2009	Conversely, BMP activation at high oxygen tension led to reciprocal degradation of HIF1alpha; this BMP-induced degradation was inhibited in low oxygen.	Oxygen	144-150	bone morphogenetic protein 1	Homo sapiens	99-102
31358683-9	2020	Remarkably, methylation of the second exon of HR4 is not only reduced in ago4-1 but also in plants overexpressing a constitutively stable version of the oxygen sensor RELATED TO APETALA2 12 (RAP2.12), indicating convergence of oxygen signaling with epigenetic regulation of gene expression.	Oxygen	153-159	homolog of RPW8 4	Arabidopsis thaliana	46-49
18844275-4	2009	RESULTS: The o/e LHR provided significant prediction of the need for prosthetic patch repair, duration of assisted ventilation, need for supplemental oxygen at 28 days, and incidence of feeding problems.	Oxygen	150-156	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	17-20
31358683-9	2020	Remarkably, methylation of the second exon of HR4 is not only reduced in ago4-1 but also in plants overexpressing a constitutively stable version of the oxygen sensor RELATED TO APETALA2 12 (RAP2.12), indicating convergence of oxygen signaling with epigenetic regulation of gene expression.	Oxygen	227-233	homolog of RPW8 4	Arabidopsis thaliana	46-49
31887216-3	2019	The caspase independent cell death could be induced by the depletion of glutathione by erastin or by the inhibition of the lipid peroxide scavenger enzyme GPX4 by RSL3 and it was accompanied by the generation of lipid reactive oxygen species.	Oxygen	227-233	glutathione peroxidase 4	Homo sapiens	155-159
18647136-10	2008	In this case, the co-planarity between the copper atom, the oxygen of the C-1 and the ring would only permit the oxidation/reduction reaction on one copper atom, giving rise to copper(0), hydrogen peroxide and an o-quinone, which would be released, thus inactivating the enzyme.	Oxygen	60-66	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	74-77
31912702-6	2019	Oxygen-glucose deprivation up-regulated the expression of regulator of reprogramming, and regulator of reprogramming promoted ASK-1/STRAP/14-3-3 complex formation to inhibit the activation of TNF-alpha/ASK-1-mediated apoptosis of human brain microvascular endothelial cells, while small interfering ribonucleic acid (RNA) targeting regulator of reprogramming amplified these effects.	Oxygen	0-6	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	126-131
18652572-9	2008	Peptide mass mapping studies with HOSCN-treated myoglobin, showed the addition of two oxygen atoms on either Trp(7) or Trp(14) with equimolar or less oxidant, and the addition of a further two oxygen atoms to the other tryptophan with higher oxidant concentrations (&gt; or = 2-fold).	Oxygen	86-92	myoglobin	Homo sapiens	48-57
18652572-9	2008	Peptide mass mapping studies with HOSCN-treated myoglobin, showed the addition of two oxygen atoms on either Trp(7) or Trp(14) with equimolar or less oxidant, and the addition of a further two oxygen atoms to the other tryptophan with higher oxidant concentrations (&gt; or = 2-fold).	Oxygen	193-199	myoglobin	Homo sapiens	48-57
19513357-2	2008	The increase in oxygen consumption under these condition was comparable to that in melittin- and arachidonic acid-induced activation of phospholipase A2 in cardiomyocytes of intact animals.	Oxygen	16-22	phospholipase A2 group IB	Rattus norvegicus	136-152
19513357-3	2008	Bromophenacyl bromide inhibition of phospholipase A2 in cardiomyocytes of rats with postinfarction cardiosclerosis led to reduction of oxygen consumption rate to values characteristic of intact animal cardiomyocytes.	Oxygen	135-141	phospholipase A2 group IB	Rattus norvegicus	36-52
19513357-4	2008	The results confirm the hypothesis according to which high oxygen consumption in postinfarction cardiosclerosis is related to increased activity of phospholipase A2.	Oxygen	59-65	phospholipase A2 group IB	Rattus norvegicus	148-164
31912702-6	2019	Oxygen-glucose deprivation up-regulated the expression of regulator of reprogramming, and regulator of reprogramming promoted ASK-1/STRAP/14-3-3 complex formation to inhibit the activation of TNF-alpha/ASK-1-mediated apoptosis of human brain microvascular endothelial cells, while small interfering ribonucleic acid (RNA) targeting regulator of reprogramming amplified these effects.	Oxygen	0-6	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	202-207
20193488-10	2010	GLUT-4 mRNA and protein expression was significantly reduced after CIH compared with CCH or normal oxygen rats, 0.002 +/- 0.002 vs. 0.039 +/- 0.009, P &lt; 0.001; 0.642 +/- 0.073 vs. 1.000 +/- 0.103, P = 0.035.	Oxygen	99-105	solute carrier family 2 member 4	Rattus norvegicus	0-6
31790227-2	2019	Herein, based on a series of metal-free single-layer graphene nanodisks (GNDs) with different surface contents of oxygen-containing groups for highly efficient electrocatalytic reduction reaction of CO2 (CO2RR) to produce formate (HCOO-), we find that the CO2RR catalytic performance is only positively correlated with the surface content of carboxyl groups.	Oxygen	114-120	complement C2	Homo sapiens	204-209
18655197-10	2008	These data suggest that 100% O(2) resuscitation increases Bax-mediated activation of ER cell death signaling, inflammation, and lesion volume by increasing necrotic-like cell death.	Oxygen	29-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	58-61
31790227-3	2019	While significantly, the density functional theory calculations demonstrate that the observed high CO2RR catalytic activity originates not from the solo carboxyl or other oxygen-containing groups, but from the synergistic effect between carboxyl groups and adjacent other types of groups (namely hydroxyl, epoxide and carbonyl) on GNDs.	Oxygen	171-177	complement C2	Homo sapiens	99-104
18950145-6	2008	The DZP-RPBE combination is found to perform well; it is thereafter used along with MP2 calculations to determine the physisorption characteristics of atomic oxygen on graphitic surfaces.	Oxygen	158-164	tryptase pseudogene 1	Homo sapiens	84-87
19836457-4	2010	Recently it was discovered that in the heart myoglobin changes its function in dependence of oxygen tension, acting as an oxygen sensor.	Oxygen	93-99	myoglobin	Homo sapiens	45-54
31878047-9	2019	Reactive oxygen species (ROS) appeared to play a key role in ASC stimulation as the inhibition of ROS generation and NOX4 knockout attenuated ASC stimulation and THPO upregulation by HB-EGF.	Oxygen	9-15	heparin binding EGF like growth factor	Homo sapiens	183-189
19836457-4	2010	Recently it was discovered that in the heart myoglobin changes its function in dependence of oxygen tension, acting as an oxygen sensor.	Oxygen	122-128	myoglobin	Homo sapiens	45-54
18806211-0	2008	Oxygen-dependent transcriptional regulator Hap1p limits glucose uptake by repressing the expression of the major glucose transporter gene RAG1 in Kluyveromyces lactis.	Oxygen	0-6	Hap1p	Saccharomyces cerevisiae S288C	43-48
18806211-1	2008	The HAP1 (CYP1) gene product of Saccharomyces cerevisiae is known to regulate the transcription of many genes in response to oxygen availability.	Oxygen	125-131	Hap1p	Saccharomyces cerevisiae S288C	4-8
19775311-2	2010	Previous reports have shown high LT mortality in HPS and severe HPS (arterial oxygen (PaO(2)) &lt; or =50 mmHg).	Oxygen	78-84	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	64-67
18806211-1	2008	The HAP1 (CYP1) gene product of Saccharomyces cerevisiae is known to regulate the transcription of many genes in response to oxygen availability.	Oxygen	125-131	Hap1p	Saccharomyces cerevisiae S288C	10-14
31920923-8	2019	In vitro, treatment of PC12 cells with 100 muM SEH markedly reduced cell death induced by oxygen-glucose deprivation through the activation of PI3K/Akt/nuclear factor kappa B pathway, and the therapeutic effect of SEH was obviously inhibited by 10 muM LY294002.	Oxygen	90-104	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	143-174
18806211-3	2008	It is suspected that a difference in the interaction of Hap1p with its target genes may explain some of the species-related variation in oxygen responses.	Oxygen	137-143	Hap1p	Saccharomyces cerevisiae S288C	56-61
18922940-2	2008	SphK1 activity is stimulated under low oxygen conditions and regulated by reactive oxygen species.	Oxygen	39-45	sphingosine kinase 1	Homo sapiens	0-5
31387048-5	2019	The results showed that the short-time 80% oxygen pretreatment possessed significantly anti-browning effect by retarding the increase of polyphenol oxidase (PPO) activity and the accumulation of malondialdehyde (MDA) content, maintaining the cell integrity.	Oxygen	43-49	catechol oxidase B, chloroplastic	Solanum tuberosum	137-155
18619520-0	2008	EEG, ECG and oxygen concentration changes from sea level to a simulated altitude of 4000m and back to sea level.	Oxygen	13-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
19914348-0	2010	A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium.	Oxygen	89-91	S-phase kinase associated protein 1	Homo sapiens	70-74
19914348-6	2010	Skp1 is a target of a novel cytoplasmic O-glycosylation pathway that modifies HyPro143 with a pentasaccharide, and glycosyltransferase mutants reveal that glycosylation intermediates have antagonistic effects toward P4H1 in O(2)-signaling.	Oxygen	224-228	S-phase kinase associated protein 1	Homo sapiens	0-4
19816693-0	2010	Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings.	Oxygen	0-6	uncoupling protein 1	Homo sapiens	35-38
18619520-0	2008	EEG, ECG and oxygen concentration changes from sea level to a simulated altitude of 4000m and back to sea level.	Oxygen	13-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
31387048-5	2019	The results showed that the short-time 80% oxygen pretreatment possessed significantly anti-browning effect by retarding the increase of polyphenol oxidase (PPO) activity and the accumulation of malondialdehyde (MDA) content, maintaining the cell integrity.	Oxygen	43-49	catechol oxidase B, chloroplastic	Solanum tuberosum	157-160
19816693-0	2010	Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings.	Oxygen	0-6	solute carrier family 25 member 6	Homo sapiens	43-46
31387048-6	2019	Meanwhile, the 80% oxygen treatment could increase the activities of phenylalanine ammonia lyase (PAL) and peroxidase (POD), and the total phenolic content.	Oxygen	19-25	phenylalanine ammonia-lyase	Solanum tuberosum	69-96
31387048-6	2019	Meanwhile, the 80% oxygen treatment could increase the activities of phenylalanine ammonia lyase (PAL) and peroxidase (POD), and the total phenolic content.	Oxygen	19-25	phenylalanine ammonia-lyase	Solanum tuberosum	98-101
31615807-8	2019	Analysis of gene expression data from neuroblastoma patients revealed that MYCN was associated with increased reactive oxygen species (ROS), downregulated mitophagy and poor prognosis.	Oxygen	119-125	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	75-79
19953516-2	2010	Mb"s function, most often considered just an oxygen repository, has considerably diversified over the last 15 years, especially because it was shown to have a role in the biochemistry of quenching and synthesizing nitric oxide in the red muscle, thereby protecting the cell.	Oxygen	45-51	myoglobin	Homo sapiens	0-2
19947986-8	2010	RESULTS: The administration of 1 L more oxygen during the night resulted in improved parameters of nocturnal oxygenation (oxygen pulse oximetry saturation-SpO2; percentage of sleep time spent at SpO2&lt;90%-CT90; PaO2 at awakening).	Oxygen	40-46	kinesin family member 20B	Homo sapiens	207-211
18467023-5	2008	The IGFBPs contributed to reduced IGF signaling and to the survival of cancer cells under conditions of low oxygen tension.	Oxygen	108-114	insulin like growth factor binding protein 1	Homo sapiens	4-10
18665600-3	2008	When the temperature is increased and H approaches, the H-CO 2 complex flips and binds to the surface through the two oxygen atoms, while H binds to the carbon atom, thus yielding formate.	Oxygen	118-124	complement C2	Homo sapiens	58-62
18680248-2	2008	Oxygen mixing is observed in temperature-programmed desorption measurements when a Au(111) precovered with 16O is exposed to isotopically labeled CO2 (C18O2).	Oxygen	0-6	complement C2	Homo sapiens	151-156
20407481-0	2010	Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures.	Oxygen	47-53	secreted phosphoprotein 1	Homo sapiens	32-43
31842349-0	2019	Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation.	Oxygen	76-82	transformation related protein 53, pseudogene	Mus musculus	8-11
31748766-1	2019	Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen storage, oxygen activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.	Oxygen	67-73	myoglobin	Homo sapiens	185-194
19944667-1	2010	Flavoprotein monooxygenases reduce flavins, speed their reaction with oxygen, and stabilize a C4a-oxygen adduct long enough to use this reactive species to transfer an oxygen atom to a substrate.	Oxygen	17-23	complement C4A (Rodgers blood group)	Homo sapiens	94-97
18616285-7	2008	The most significant finding was that berberine was reoriented in the QacR multidrug binding pocket so that its positive charge was neutralized by side chain oxygen atoms and aromatic residues.	Oxygen	158-164	QacR	Staphylococcus aureus	70-74
31754670-2	2019	A Yb(OTf)3-catalyzed reaction between o-alkynylnaphthols and 3-methyleneindolin-2-ones proceeded efficiently, and provided a simple and convergent protocol for alkyne difunctionalization via oxidant-free C-C double bond breaking/rearrangement.	Oxygen	38-56	POU class 5 homeobox 1	Homo sapiens	5-10
17462814-3	2008	The methodology is demonstrated by applying it separately to a set of general water quality indicators (total suspended solids, biochemical and chemical oxygen demand, nitrates, phosphates and faecal coliforms) to produce a ranked list of BMP pollutant removal efficiencies.	Oxygen	153-159	bone morphogenetic protein 1	Homo sapiens	239-242
18665949-7	2008	That must be combined with maintenance of training velocities and oxygen flux to realize the improvement in subsequent sea level performance.	Oxygen	66-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	119-122
18665950-1	2008	The increase in oxygen transport elicited by several weeks of exposure to moderate to high altitude is used to increase physical performance when returning to sea level.	Oxygen	16-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	159-162
20193091-8	2010	Switching to 19% oxygen during Phase II resulted in reduced synthesis of proteoglycan and collagen, increased release of MMPs, accumulation of type II collagen fragments and higher branching of collagen fibrils.	Oxygen	17-23	matrix metallopeptidase 1	Homo sapiens	121-125
21364629-4	2010	Accordingly, PRELI can uphold mitochondrial membrane potential (DeltaPsi(m)) and enhance respiratory chain (RC) function, shown by its capacity to induce complex-I/NADH dehydrogenase and ATP synthase expression, increase oxygen consumption and reduce reactive oxygen species (ROS) production.	Oxygen	221-227	PRELI domain containing 1	Homo sapiens	13-18
31815003-6	2019	mCD40L triggered reactive oxygen species (ROS) production, critical in apoptosis, and NADPH oxidase (Nox)-subunit p40phox phosphorylation, with Nox blockade abrogating apoptosis thus implying Nox-dependent initial ROS release.	Oxygen	26-32	CD40 ligand	Mus musculus	0-6
20517717-3	2010	In recent years, high tumor cell levels of HIF-2 and the oxygen sensitive subunit HIF-2alpha have been associated with unfavorable disease and shown to be highly expressed in tumor stem/initiating cells originating from neuroblastoma and glioma, respectively.	Oxygen	57-63	endothelial PAS domain protein 1	Homo sapiens	82-92
18690587-5	2008	Meanwhile, anaerobic glycolysis and internal stores of oxygen like mixed venous blood and myoglobin as well as internal stores of high-energy phosphates like phosphocreatine (PCr) are adducted for the provision of additional adenosine-triphosphate (ATP), which is consumed by the ATPase at the myofibrils in order to fuel muscle contraction.	Oxygen	55-61	myoglobin	Homo sapiens	90-99
31606204-1	2019	Our previous investigation indicated that angiotensin II (Ang II) enhances the expression of Kv1.5, a promising target for the treatment of atrial fibrillation (AF), by activating reactive oxygen species (ROS)-dependent phosphorylation of Smad 2/3 (forming P-Smad 2/3) and ERK 1/2 (forming P-ERK 1/2).	Oxygen	189-195	SMAD family member 2	Rattus norvegicus	239-247
18372923-8	2008	We propose that alpha-TOS displaces UbQ in CII causing electrons generated by SDH to recombine with molecular oxygen to yield ROS.	Oxygen	110-116	aminoadipate-semialdehyde synthase	Mus musculus	78-81
21302556-5	2010	Laboratory studies using the pulsed laser photolysis/laser induced fluorescence and flow tube/mass spectrometer techniques were used to measure the following rate coefficients: k (Mg+ + CO2 (+ CO2) --&gt; Mg+ x CO2, 190-403 K) = (5.3 +/- 0.7) x 10(-29) (T/300 K)(-1.86 +/- 0.03) cm6 molecule --&gt; 2 s(-1); k(Mg+ x CO2 + O2 --&gt; MgO2(+) + CO2, 297 K) = (2.2 +/- 0.8) x 10(-11) cm3 molecule(-1) s(-1); k(MgO2(+) + O --&gt; MgO(+) + O2, 297 K) = (6.5 +/- 1.8) x 10(-10) cm3 molecule(-1) s(-1); and k(MgO(+) + O --&gt; Mg(+) + O2, 297 K) = (5.9 +/- 2.4) x 10(-10) cm3 molecule(-1) s(-1).	Oxygen	187-189	complement C2	Homo sapiens	193-196
21302556-5	2010	Laboratory studies using the pulsed laser photolysis/laser induced fluorescence and flow tube/mass spectrometer techniques were used to measure the following rate coefficients: k (Mg+ + CO2 (+ CO2) --&gt; Mg+ x CO2, 190-403 K) = (5.3 +/- 0.7) x 10(-29) (T/300 K)(-1.86 +/- 0.03) cm6 molecule --&gt; 2 s(-1); k(Mg+ x CO2 + O2 --&gt; MgO2(+) + CO2, 297 K) = (2.2 +/- 0.8) x 10(-11) cm3 molecule(-1) s(-1); k(MgO2(+) + O --&gt; MgO(+) + O2, 297 K) = (6.5 +/- 1.8) x 10(-10) cm3 molecule(-1) s(-1); and k(MgO(+) + O --&gt; Mg(+) + O2, 297 K) = (5.9 +/- 2.4) x 10(-10) cm3 molecule(-1) s(-1).	Oxygen	187-189	complement C2	Homo sapiens	193-196
21302556-5	2010	Laboratory studies using the pulsed laser photolysis/laser induced fluorescence and flow tube/mass spectrometer techniques were used to measure the following rate coefficients: k (Mg+ + CO2 (+ CO2) --&gt; Mg+ x CO2, 190-403 K) = (5.3 +/- 0.7) x 10(-29) (T/300 K)(-1.86 +/- 0.03) cm6 molecule --&gt; 2 s(-1); k(Mg+ x CO2 + O2 --&gt; MgO2(+) + CO2, 297 K) = (2.2 +/- 0.8) x 10(-11) cm3 molecule(-1) s(-1); k(MgO2(+) + O --&gt; MgO(+) + O2, 297 K) = (6.5 +/- 1.8) x 10(-10) cm3 molecule(-1) s(-1); and k(MgO(+) + O --&gt; Mg(+) + O2, 297 K) = (5.9 +/- 2.4) x 10(-10) cm3 molecule(-1) s(-1).	Oxygen	187-189	complement C2	Homo sapiens	193-196
21614205-7	2010	Meanwhile, Fe-chlorophyllin treatment could increase the activities of reactive oxygen scavenging enzymes, such as superoxide dismutase (SOD) and peroxidase (POD), as determined using non-denaturing polyacrylamide gel electrophoresis.	Oxygen	80-86	peroxidase-like	Triticum aestivum	146-156
21614205-7	2010	Meanwhile, Fe-chlorophyllin treatment could increase the activities of reactive oxygen scavenging enzymes, such as superoxide dismutase (SOD) and peroxidase (POD), as determined using non-denaturing polyacrylamide gel electrophoresis.	Oxygen	80-86	peroxidase-like	Triticum aestivum	158-161
19949104-1	2010	Hypoxia-inducible factor (HIF)-1alpha plays a central role in oxygen homeostasis and energy supply by glycolysis in many cell types.	Oxygen	62-68	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
18430561-3	2008	POX catalyzes the degradation of pyruvate to acetylphosphate, CO(2) and H(2)O(2) in the presence of phosphate and oxygen.	Oxygen	114-120	proline dehydrogenase 1	Homo sapiens	0-3
19469122-2	2008	It has been proven that calm breathing of 100% oxygen allows for removal of 95% of the nitrogen from the body, replacing it with oxygen.	Oxygen	47-53	synaptosome associated protein 91	Homo sapiens	24-28
31629202-7	2019	In this study, we examined how the double exposure of Cd and fluctuations in oxygen affects denitrification in Baltic Sea sediment.	Oxygen	77-83	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
19469122-2	2008	It has been proven that calm breathing of 100% oxygen allows for removal of 95% of the nitrogen from the body, replacing it with oxygen.	Oxygen	129-135	synaptosome associated protein 91	Homo sapiens	24-28
19469122-5	2008	Calm breathing over 3 min via a tight face mask, of 100% oxygen delivered from the circle system, with a fresh gas flow of more than 8 L min-1; 2.	Oxygen	57-63	synaptosome associated protein 91	Homo sapiens	0-4
18539027-1	2008	Replacement of the 7-CH2 group of natural steroid with an oxygen atom led to identification of unnatural 7-oxa-steroids as potent and selective progesterone receptor antagonists.	Oxygen	58-64	progesterone receptor	Rattus norvegicus	144-165
19844076-6	2010	In patients with polymorphic variants of the BMPR2 gene, the number of blood platelets and oxygen saturation were increased.	Oxygen	91-97	bone morphogenetic protein receptor type 2	Homo sapiens	45-50
31711824-11	2019	Significant correlations between Cel-ind in CMR and cardiopulmonary parameters were found (for peak oxygen uptake: R = -0.35, P = 0.034; for the ventilation/carbon dioxide slope: R = 0.46, P = 0.005).	Oxygen	100-106	carboxyl ester lipase	Homo sapiens	33-36
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	granzyme B	Homo sapiens	63-73
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	Fas cell surface death receptor	Homo sapiens	130-134
17726065-4	2008	In this study it was found that during rest at sea level, the haemoglobin oxygen saturation, as measured by pulse oxymetry, is slightly higher in women than in men (98.6 (SD 1.1)% versus 97.9 (SD 0.9)%; p = 0.001).	Oxygen	74-80	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
18593917-5	2008	It was found that HIF-1alpha binds hARD1 through the oxygen-dependent degradation domain and, in so doing, dissociates hARD1 from beta-catenin, which prevents beta-catenin acetylation.	Oxygen	53-59	catenin beta 1	Homo sapiens	130-142
31669130-0	2019	LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122.	Oxygen	35-41	microRNA 122	Rattus norvegicus	130-137
20087303-9	2009	When pedaling at 70 RPM, the oxygen consumption and heart rate response (as % of VO(2peak) and HR(peak)) were approximately 45% and 60% for WSB1, 60% and 70% for WSB3, 90% and 90% for WSB2 and WSB4, respectively.	Oxygen	29-35	WD repeat and SOCS box containing 1	Homo sapiens	140-144
31631486-6	2019	In addition, we indicated that lncRNA MEG3 knockdown reduced myocyte apoptosis and reactive oxygen species production in MI mice model and hypoxic NMVMs.	Oxygen	92-98	maternally expressed 3	Mus musculus	38-42
19930602-9	2009	There was a strong negative correlation between arterial oxygen saturation and EpoR labelling of glia (P = .001).	Oxygen	57-63	erythropoietin receptor	Homo sapiens	79-83
19844232-7	2009	RESULTS: Exposure to 0.1% oxygen resulted in elevated levels of Snail protein, along with changes in vimentin and E-cadherin expression, and in addition increased migration of MDA-MB-468 cells.	Oxygen	26-32	vimentin	Homo sapiens	101-109
18407268-8	2008	Oxygen was supplied to the respiratory tract through the channel for gas in the MAUGE and through the mask by using positive pressure ventilation by bag-valve-mask ventilation.	Oxygen	0-6	ankyrin repeat and KH domain containing 1	Homo sapiens	102-106
18407268-8	2008	Oxygen was supplied to the respiratory tract through the channel for gas in the MAUGE and through the mask by using positive pressure ventilation by bag-valve-mask ventilation.	Oxygen	0-6	ankyrin repeat and KH domain containing 1	Homo sapiens	159-163
31420910-4	2019	Using isolated mouse brain mitochondria, DOPAL-oligomerized alpha-synuclein (DOS) significantly inhibited oxygen consumption rates compared with untreated, control-fibrillated, and dopamine-fibrillated synuclein, or with monomeric alpha-synuclein.	Oxygen	106-112	synuclein, alpha	Mus musculus	60-75
18398221-6	2008	At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP).	Oxygen	60-66	patatin like phospholipase domain containing 8	Homo sapiens	30-42
20113663-0	2009	[Effects of prolonged exposure of high concentration of oxygen on expression of vascular endothelial growth factor and its receptors in neonatal rat lungs].	Oxygen	56-62	vascular endothelial growth factor A	Rattus norvegicus	80-114
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	49-55	vascular endothelial growth factor A	Rattus norvegicus	86-120
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	49-55	vascular endothelial growth factor A	Rattus norvegicus	122-126
31601683-12	2019	These data demonstrate that PTP4A phosphatases can be selectively targeted with small molecules that lack prominent reactive oxygen generation and encourage further studies of this chemotype.	Oxygen	125-131	protein tyrosine phosphatase 4A2	Homo sapiens	28-33
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	49-55	kinase insert domain receptor	Rattus norvegicus	158-164
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	268-274	vascular endothelial growth factor A	Rattus norvegicus	86-120
20113663-1	2009	OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia (BPD).	Oxygen	268-274	vascular endothelial growth factor A	Rattus norvegicus	122-126
19770585-3	2009	We recently reported that physiologic oxygen levels differentially induce hypoxia inducible factor-2alpha (HIF2alpha) levels in cancer stem cells.	Oxygen	38-44	endothelial PAS domain protein 1	Homo sapiens	74-105
19770585-3	2009	We recently reported that physiologic oxygen levels differentially induce hypoxia inducible factor-2alpha (HIF2alpha) levels in cancer stem cells.	Oxygen	38-44	endothelial PAS domain protein 1	Homo sapiens	107-116
19764800-8	2009	Protein-electrode orientation and efficient intraheme ET enable the His,OH(-)-ligated heme A of the immobilized Met64Ala variant to carry out the reductive electrocatalysis of molecular oxygen.	Oxygen	186-192	hemE	Pseudoalteromonas haloplanktis TAC125	49-53
18392752-9	2008	We suggest that such a protective effect may be ascribable to a reduced 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R) activity, a statin-like effect, as well as to a downregulation in NADPH oxidase activity with a consequent reduction in oxygen-free radical production.	Oxygen	252-258	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	121-130
18463291-5	2008	Coordination of the complexes to Abeta altered the chemical properties of the peptide inhibiting amyloid formation and the generation of reactive oxygen species.	Oxygen	146-152	amyloid beta (A4) precursor protein	Mus musculus	33-38
18451767-3	2008	The genetic basis of singlet-oxygen-mediated signalling has been revealed by the mutation of two nuclear genes encoding the plastid proteins EXECUTER (EX)1 and EX2, which are sufficient to abrogate singlet-oxygen-dependent stress responses.	Oxygen	29-35	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	160-163
18451767-3	2008	The genetic basis of singlet-oxygen-mediated signalling has been revealed by the mutation of two nuclear genes encoding the plastid proteins EXECUTER (EX)1 and EX2, which are sufficient to abrogate singlet-oxygen-dependent stress responses.	Oxygen	206-212	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	160-163
31610205-7	2019	Importantly, reactive oxygen species (ROS) signaling pathway mediated oroxylin A-induced ATGL downregulation and LD revision in activated HSCs.	Oxygen	22-28	patatin like phospholipase domain containing 2	Homo sapiens	89-93
18423190-3	2008	(2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to alterations in cutaneous blood flow that affect the production of the hormone erythropoietin, thereby modulating red blood cell production and the O2-carrying capacity of blood.	Oxygen	68-70	erythropoietin	Mus musculus	192-206
18423190-3	2008	(2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to alterations in cutaneous blood flow that affect the production of the hormone erythropoietin, thereby modulating red blood cell production and the O2-carrying capacity of blood.	Oxygen	261-263	erythropoietin	Mus musculus	192-206
19202005-8	2009	Increased surfactant surface tension caused by reduction in SP-B induced narrowing of alveolar capillaries and oxygen desaturation, demonstrating an important role of surface tension-lowering properties of surfactant in the regulation of pulmonary vascular perfusion.	Oxygen	111-117	surfactant associated protein B	Mus musculus	60-64
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	activating transcription factor 3	Homo sapiens	146-150
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Oxygen	190-196	caspase 7	Homo sapiens	27-36
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Oxygen	190-196	caspase 7	Homo sapiens	200-209
18030677-3	2008	We investigated the temporal and spatial patterns of c-Fos expression in postnatal day 7 mice after unilateral carotid ligation and exposure to 8% oxygen.	Oxygen	147-153	FBJ osteosarcoma oncogene	Mus musculus	53-58
18373847-5	2008	The transcription of HXT2, HXT4 and HXT5 was low when the oxygen concentration in the cultures was low, both under steady state and non-steady state conditions, whereas the expression of HXT6, HXT13 and HXT15/16 was higher in hypoxic than in fully aerobic or anaerobic conditions.	Oxygen	58-64	hexose transporter HXT5	Saccharomyces cerevisiae S288C	36-40
31744422-7	2019	High mam levels in niche cells induce reduced Hedgehog amounts, a decrease in cadherin levels and a likely increase in reactive oxygen species, three scenarios known to provoke GSC loss.	Oxygen	128-134	mastermind	Drosophila melanogaster	5-8
18281021-4	2008	To this end, we studied the impact of hypoxia in the presence or absence of LEV on the O2-dependent HIF-1alpha subunit as well as on VEGF and iNOS in the developing brain of normoxic and hypoxic mice.	Oxygen	87-89	hypoxia inducible factor 1, alpha subunit	Mus musculus	100-110
19694727-8	2009	CONCLUSIONS AND IMPLICATIONS: These data provided an explanation for how CO might regulate sensory neuronal traffic in physiological reflexes such as systemic oxygen sensing but also showed that CO could be used as a selective pharmacological tool to assess the involvement of homomeric P2X(2) receptors in physiological systems.	Oxygen	159-165	purinergic receptor P2X 2	Homo sapiens	287-293
19661455-1	2009	The purpose of this study was to determine the myoglobin concentration in skeletal muscle fibers of chronic heart failure (CHF) patients and to calculate the effect of myoglobin on oxygen buffering and facilitated diffusion.	Oxygen	181-187	myoglobin	Homo sapiens	168-177
19661455-5	2009	Consequently, the oxygen buffering capacity, calculated from myoglobin concentration/SDH activity was increased in CHF: type I fibers 11.4 +/- 2.1 s, type II fibers 13.6 +/- 3.9 s in CHF vs. type I fibers 7.8 +/- 0.9 s, type II fibers 7.5 +/- 1.0 s in control, all P &lt; 0.01).	Oxygen	18-24	myoglobin	Homo sapiens	61-70
31670934-3	2019	Moreover, the local atomic configuration and bond distance studies show that trivalent Co3+ states are partially reduced through nitrogen radicals in the plasma to low-coordinated bivalent Co2+ states playing as the facile adsorption sites of oxygen-evolving intermediates due to the decreased activation barrier for water oxidation.	Oxygen	243-249	complement C2	Homo sapiens	189-192
18335029-6	2008	At a precise concentration, insulin increased phospho-Akt2 that translocates to mitochondria and determines in situ phosphorylation and substantial cooperative mtNOS activation (+4-8 fold, P&lt;.05), high NO, and a lowering of mitochondrial oxygen uptake and resting metabolic rate (-25 to -60%, P&lt;.05).	Oxygen	241-247	AKT serine/threonine kinase 2	Homo sapiens	54-58
18077097-3	2008	In turn, LacCer activates an "oxygen-sensitive" signaling pathway involving superoxides, nitric oxide, p21 Ras GTP loading, kinase cascade, PI3kinase/Akt activation, nuclear factor up-regulation ultimately contributing to phenotypic changes such as cell proliferation, adhesion, migration and angiogenesis.	Oxygen	30-36	H3 histone pseudogene 16	Homo sapiens	103-106
17962570-5	2008	Changes in convective O(2) delivery in the healthy human can result from modifications in arterial O(2) content, blood flow, or a combination of both, and they can be induced via heavy exercise even at sea level; these changes are exacerbated during acute and chronic exposure to altitude.	Oxygen	22-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	202-205
31775033-7	2019	Conversely, Zc3h10 ablation in UCP1+ cells in mice impairs thermogenic capacity and lowers oxygen consumption, leading to weight gain.	Oxygen	91-97	zinc finger CCCH type containing 10	Mus musculus	12-18
18311277-1	2008	We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin (HbO(2)) absorption coefficients around 800 nm.	Oxygen	49-55	plexin A2	Homo sapiens	159-162
31636086-4	2019	The main objective of our study is to overexpress BI-1, via viral-mediated gene delivery of human adenoviral-TMBIM6 (Ad-TMBIM6) vector, to investigate its anti-apoptotic effects as well as to elucidate its signaling pathways in an in vivo neonatal HI rat model and in vitro oxygen-glucose deprivation (OGD) model.Ten-day old unsexed Sprague-Daley rat pups underwent right common carotid artery ligation followed by 1.5h of hypoxia.	Oxygen	274-280	transmembrane BAX inhibitor motif containing 6	Homo sapiens	50-54
18155142-8	2008	The expression of p53, p21 and Mdm2 in both cytotrophoblast and stromal cells was increased following culture in 1% O(2).	Oxygen	116-120	H3 histone pseudogene 16	Homo sapiens	23-26
31748500-6	2019	In contrast to its negligible impact in IGF1R signaling, loss of IGF2R disrupted the Golgi-to-lysosome transport of M6P-tagged cathepsins, resulting in decreased lysosomal activity, with their abnormal accumulation and dysfunction of both autophagy and mitophagy, which cause the accumulation of misfolded proteins and production of reactive oxygen species.	Oxygen	342-348	insulin like growth factor 2 receptor	Homo sapiens	65-70
18279587-1	2008	OBJECTIVE: To investigate the dynamic changes and the effects of metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinase-2 (TIMP-2) mRNA in lungs of neonatal rats after inhaling high concentration of oxygen.	Oxygen	215-221	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	97-137
31718692-5	2019	RESULTS: Transfecting PD-L1 in PD-L1low cells enhanced hexokinase-2 (HK2) expression, lactate production, and extracellular acidification rates, but minimally altered GLUT1 and PKM2 expression and oxygen consumption rates.	Oxygen	197-203	CD274 molecule	Homo sapiens	22-27
31718692-5	2019	RESULTS: Transfecting PD-L1 in PD-L1low cells enhanced hexokinase-2 (HK2) expression, lactate production, and extracellular acidification rates, but minimally altered GLUT1 and PKM2 expression and oxygen consumption rates.	Oxygen	197-203	CD274 molecule	Homo sapiens	31-36
17684492-2	2008	Here we investigated the potential relationship of oxygen-sensitive alpha-subunit of angiogenesis-related hypoxia-inducible factor-1alpha (HIF-1alpha) with Runt-related protein 1 (Runx1, also known as acute myeloid leukemia-1, AML-1), an important hematopoietic transcription factor.	Oxygen	51-57	RUNX family transcription factor 1	Homo sapiens	180-185
31506280-5	2019	Mechanistic studies revealed that CDK7 inhibition markedly reduces glutathione levels and increases reactive oxygen species due to reduced expression of NRF2 and glutathione biosynthesis genes.	Oxygen	109-115	cyclin-dependent kinase 7	Mus musculus	34-38
18156205-3	2008	Endoglin expression was high at 4 to 9 weeks of gestation, when oxygen tension is low, and decreased after 10 weeks, when oxygen tension increases.	Oxygen	64-70	endoglin	Homo sapiens	0-8
18156205-3	2008	Endoglin expression was high at 4 to 9 weeks of gestation, when oxygen tension is low, and decreased after 10 weeks, when oxygen tension increases.	Oxygen	122-128	endoglin	Homo sapiens	0-8
18156205-4	2008	Exposure of villous explants to low oxygen (3% O2) resulted in elevated expression of both membrane and soluble endoglin compared to standard conditions (20% O2).	Oxygen	36-42	endoglin	Homo sapiens	112-120
18156205-4	2008	Exposure of villous explants to low oxygen (3% O2) resulted in elevated expression of both membrane and soluble endoglin compared to standard conditions (20% O2).	Oxygen	47-49	endoglin	Homo sapiens	112-120
18156205-5	2008	Moreover, addition of TGF-beta 3 to villous explants under low oxygen conditions increased the expression of endoglin compared to nontreated explants whereas addition of TGF-beta 3-neutralizing antibodies inhibited the low oxygen stimulatory effect on endoglin expression.	Oxygen	63-69	endoglin	Homo sapiens	109-117
18156205-7	2008	These data demonstrate that oxygen regulates the placental expression of endoglin via TGF-beta 3.	Oxygen	28-34	endoglin	Homo sapiens	73-81
31685899-6	2019	Furthermore, NAPE-PLD silencing protects cathecolamine-producing SH-SY5Y cells from 6-OHDA-induced reactive oxygen species formation, caspase-3 activation and death.	Oxygen	108-114	N-acyl phosphatidylethanolamine phospholipase D	Homo sapiens	13-21
18491566-1	2008	Oxygen exchange at the water-bottom interface in the northeastern Black Sea was studied using bottom tanks (fluxes and oxygen consumption for organic matter mineralization and for respiration of soil and water organisms).	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
31389735-3	2019	Hypoxia (3% oxygen) caused a depletion of COMP in BPA, but not in bovine coronary arteries.	Oxygen	12-18	cartilage oligomeric matrix protein	Bos taurus	42-46
17925338-5	2008	RESULTS: In healthy young men, lipin-1 expression was positively correlated with insulin sensitivity (R2 = 0.22; P &lt; 0.01), insulin-stimulated respiratory quotient (R2 = 0.16; P &lt; 0.01), and maximal oxygen consumption during exercise (R2 = 0.16; P &lt; 0.01).	Oxygen	205-211	lipin 1	Homo sapiens	31-38
31704823-1	2019	BACKGROUND/AIM: DJ-1, an oncogenic molecule, helps to maintain somatic stem cells by reducing the intracellular level of reactive oxygen species (ROS).	Oxygen	130-136	Parkinsonism associated deglycase	Homo sapiens	16-20
31564197-6	2019	This is also consistent with the TCL1 ability to suppress mitochondrial biogenesis and oxygen consumption, downplaying the contribution of oxidative phosphorylation to energy metabolism.	Oxygen	87-93	TCL1 family AKT coactivator A	Homo sapiens	33-37
17982713-1	2008	The light, oxygen, or voltage (LOV) domain that belongs to the Per-ARNT-Sim (PAS) domain superfamily is a blue light sensory module.	Oxygen	11-17	PAS/LOV protein B	Arabidopsis thaliana	77-80
18043510-7	2008	mRNA for Vegf164 and Vegf188 was reduced during hyperoxia and addition of VEGF165, but not VEGF121, to explants grown in 50% O2 resulted in partial reversal of the decrease in lung branching, correlating with a decrease in cell apoptosis.	Oxygen	125-127	vascular endothelial growth factor A	Rattus norvegicus	9-16
31504401-6	2019	Additionally, ERbeta stimulated gene expression associated with TNFalpha/nuclear factor kappaB (NF-kappaB) signaling, epithelial-mesenchymal transition, reactive oxygen species signaling, IL-6/Janus kinase (JAK)/signal transducer and activator of transcription (STAT)3 signaling, and hypoxia signaling and suppressed IFNalpha signaling in ectopic lesions to enhance endometriosis progression.	Oxygen	162-168	estrogen receptor 1 (alpha)	Mus musculus	14-20
18269117-1	2008	At sea level oxygen is toxic to man when breathed for more than twenty-four hours at a percentage greater than about forty percent.	Oxygen	13-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	3-6
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Oxygen	29-35	growth factor, augmenter of liver regeneration	Homo sapiens	0-4
17972915-6	2007	Erv1 also utilized molecular oxygen as an electron acceptor to generate hydrogen peroxide, which is subsequently reduced to water by cytochrome c peroxidase (Ccp1).	Oxygen	29-35	coiled-coil domain containing 115	Homo sapiens	158-162
31422301-5	2019	Consequently high total organic carbon and emerging hypoxia in the Gulf may lead to expansion/intensification of the oxygen minimum zone of the Arabian Sea.	Oxygen	117-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	152-155
30953276-10	2019	These results support the observations that pretreatment with EPO reduced long-term cognitive deficits and neuronal degeneration in cortex and hippocampus induced by sevoflurane exposure with low oxygen concentration in neonatal rats.	Oxygen	196-202	erythropoietin	Rattus norvegicus	62-65
31661888-4	2019	FMN is sensitized to ultraviolet (UV) and blue light radiation, as evidenced by the generation of reactive oxygen species (ROS).	Oxygen	107-113	formin 1	Homo sapiens	0-3
31641109-5	2019	Here we demonstrate for the first time that loss of MLH1 is associated with a deregulated mitochondrial metabolism, with reduced basal oxygen consumption rate and reduced spare respiratory capacity.	Oxygen	135-141	mutL homolog 1	Homo sapiens	52-56
19908505-0	2009	Electrocatalyzed O2 response of myoglobin immobilized on multi-walled carbon nanotube forest electrodes.	Oxygen	17-19	myoglobin	Homo sapiens	32-41
19908505-1	2009	Direct electrochemistry and activity of myoglobin (Mb) immobilized on carbon nanotube (CNT) forest electrodes were investigated by probing mainly its electrocatalytical response towards oxygen.	Oxygen	186-192	myoglobin	Homo sapiens	40-49
19908505-1	2009	Direct electrochemistry and activity of myoglobin (Mb) immobilized on carbon nanotube (CNT) forest electrodes were investigated by probing mainly its electrocatalytical response towards oxygen.	Oxygen	186-192	myoglobin	Homo sapiens	51-53
19908505-4	2009	Conformational changes together with the consequent loss of oxygen affinity were recorded at low pH, which delimits the operative range of the Mb/CNT electrodes for sensing purposes.	Oxygen	60-66	myoglobin	Homo sapiens	143-145
31465303-8	2019	Together, our findings support a model in which loss of KMT2D function suppresses expression of oxygen-responsive gene programs important to neural progenitor maintenance, resulting in precocious neuronal differentiation in a mouse model of KS1.	Oxygen	96-102	lysine (K)-specific methyltransferase 2D	Mus musculus	56-61
19849936-10	2009	Arterial oxygen saturation was negatively correlated with serum VEGF (p&lt;0.01) and LEP levels (p&lt;0.01) in the CCHD group.	Oxygen	9-15	leptin	Homo sapiens	85-88
19707690-2	2009	Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group.	Oxygen	133-137	CD24 molecule	Rattus norvegicus	96-100
31737185-0	2019	DPP-4 inhibitor saxagliptin ameliorates oxygen deprivation/reoxygenation-induced brain endothelial injury.	Oxygen	40-46	dipeptidyl peptidase 4	Homo sapiens	0-5
19533753-4	2009	We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP).	Oxygen	52-58	ceruloplasmin	Homo sapiens	126-128
19533753-4	2009	We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP).	Oxygen	52-58	ceruloplasmin	Homo sapiens	154-156
31681203-5	2019	Furthermore, the level of reactive oxygen species (ROS) in fungal protoplast was increased (3.1- to 3.8-fold) in response to TCDD exposure at 10 and 50 ng mL-1, respectively.	Oxygen	35-41	L1 cell adhesion molecule	Mus musculus	155-159
19473963-4	2009	The relative functions of the PFKFB3 and PFKFB4 enzymes are of particular interest because they are activated in human cancers and increased by mitogens and low oxygen.	Oxygen	161-167	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	30-36
31632086-2	2019	Exportin 1 (XPO1), the major nuclear export receptor, is involved in the cellular adaptation to reduced oxygen availability by controlling the nuclear activity of the hypoxia-inducible factors (HIFs).	Oxygen	104-110	exportin 1	Homo sapiens	0-10
19473963-4	2009	The relative functions of the PFKFB3 and PFKFB4 enzymes are of particular interest because they are activated in human cancers and increased by mitogens and low oxygen.	Oxygen	161-167	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	41-47
31632086-2	2019	Exportin 1 (XPO1), the major nuclear export receptor, is involved in the cellular adaptation to reduced oxygen availability by controlling the nuclear activity of the hypoxia-inducible factors (HIFs).	Oxygen	104-110	exportin 1	Homo sapiens	12-16
31523952-2	2019	Current densities during the oxygen evolution reaction (OER) with a NiFeOx catalyst at 2 V vs. RHE were increased 5-fold when substituting commercial FTO (TEC 15) by nanostructured FTO scaffolds.	Oxygen	29-35	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	150-153
19730430-7	2009	The oxygen free radical scavenger catalase and superoxide dismutase reduced the inactivation of CDC25 by LGH00031, confirming that reactive oxygen species (ROS) mediate the inactivation process in vitro.	Oxygen	4-10	cell division cycle 25C	Homo sapiens	96-101
19568936-9	2009	We found that decreases in diffusion capacity which would have minimal effects at sea level produced significant disequilibrium of gas tensions and a large fall in hemoglobin oxygen saturation at a cabin altitude of 4000-8000 ft. As demonstrated, this new model could serve as an important tool to examine the important physiological consequences of decompression scenarios in aircraft and the pathophysiological situations in which the equilibrium of gas tensions along the pulmonary capillary are particularly critical.	Oxygen	175-181	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	82-85
31523952-2	2019	Current densities during the oxygen evolution reaction (OER) with a NiFeOx catalyst at 2 V vs. RHE were increased 5-fold when substituting commercial FTO (TEC 15) by nanostructured FTO scaffolds.	Oxygen	29-35	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	181-184
19690266-1	2009	BACKGROUND: A variety of near-infrared spectroscopy devices can be used to make noninvasive measurements of cerebral tissue oxygen saturation (ScO2).	Oxygen	124-130	synthesis of cytochrome C oxidase 2	Homo sapiens	143-147
31632027-8	2019	Furthermore, Rh2HAZnO induced morphological changes of these cell lines, mainly intracellular reactive oxygen species (ROS) were observed by ROS staining and nucleus by Hoechst staining.	Oxygen	103-109	Rh associated glycoprotein	Homo sapiens	13-16
31503482-0	2019	Operando Characterization of Iron Phthalocyanine Deactivation during Oxygen Reduction Reaction Using Electrochemical Tip-Enhanced Raman Spectroscopy.	Oxygen	69-75	TOR signaling pathway regulator	Homo sapiens	117-120
31503482-1	2019	Electrochemical tip-enhanced Raman spectroscopy (EC-TERS) has been implemented to investigate the structure and activity of iron(II) phthalocyanine (FePc)-a model catalyst for the oxygen reduction reaction (ORR).	Oxygen	180-186	TOR signaling pathway regulator	Homo sapiens	16-19
31393787-5	2019	Mechanistically, leptin-primed immortalized Kupffer cells (a mimicked model for an NAFLD condition) treated with apocynin or nitrone spin trap 5,5 dimethyl-1- pyrroline N-oxide (DMPO) had significantly decreased CD68 and decreased miR21 and alpha-smooth muscle actin levels, suggesting the role of NOX2-dependent reactive oxygen species in miR21-induced Kupffer cell activation and stellate cell pathology.	Oxygen	322-328	leptin	Mus musculus	17-23
31232477-7	2019	The microaerobically inducible plasmid was obtained by cloning the rnaII gene under the control of the oxygen-responsive Vitreoscilla stercoraria hemoglobin promoter.	Oxygen	103-109	D616_p116001	Escherichia coli	67-72
31572534-0	2019	Annexin A2 upregulation protects human retinal endothelial cells from oxygen-glucose deprivation injury by activating autophagy.	Oxygen	70-76	annexin A2	Homo sapiens	0-10
17967019-0	2007	Reaction of Ta(NMe2)5 with O2: formation of aminoxy and unusual (aminomethyl)amide oxo complexes and theoretical studies of the mechanistic pathways.	Oxygen	27-29	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	15-19
17967019-7	2007	A key step is the oxygen insertion into a Ta-N bond in 1 through an intersystem conversion from triplet to singlet energy surface to give an active peroxide complex (Me2N)4Ta(eta2-O-O-NMe2) (A4).	Oxygen	18-24	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	184-188
31537639-4	2019	Knockout of DNMT3A alone perturbed mtDNA regional methylation patterns, but not global levels, and altered mitochondrial gene expression, copy number, and oxygen respiration.	Oxygen	155-161	DNA methyltransferase 3 alpha	Homo sapiens	12-18
17967948-5	2007	Here, we show that Erv1 passes its electrons on to molecular oxygen via interaction with cytochrome c and cytochrome c oxidase.	Oxygen	61-67	growth factor, augmenter of liver regeneration	Homo sapiens	19-23
31350168-0	2019	Improvement in Microregional Oxygen Supply/Consumption Balance and Infarct Size After Cerebral Ischemia-Reperfusion With Inhibition of p70 Ribosomal S6 Kinase (S6K1).	Oxygen	29-35	ribosomal protein S6 kinase B1	Rattus norvegicus	149-158
18225594-11	2007	RESULTS: Reduced O2 supply promoted expression of HIF-1alpha and VEGF.	Oxygen	17-19	vascular endothelial growth factor A	Rattus norvegicus	65-69
18225594-13	2007	EPO improved the O2 supply and decreased expression of growth factors but did not reduce tumor volumes.	Oxygen	17-19	erythropoietin	Rattus norvegicus	0-3
31350168-0	2019	Improvement in Microregional Oxygen Supply/Consumption Balance and Infarct Size After Cerebral Ischemia-Reperfusion With Inhibition of p70 Ribosomal S6 Kinase (S6K1).	Oxygen	29-35	ribosomal protein S6 kinase B1	Rattus norvegicus	160-164
31350168-1	2019	BACKGROUND: We tested the hypothesis that inhibition of p70 ribosomal S6 kinase (S6K1) would decrease infarct size and improve microregional O2 supply/consumption balance after cerebral ischemia-reperfusion.	Oxygen	141-143	ribosomal protein S6 kinase B1	Rattus norvegicus	70-79
31350168-1	2019	BACKGROUND: We tested the hypothesis that inhibition of p70 ribosomal S6 kinase (S6K1) would decrease infarct size and improve microregional O2 supply/consumption balance after cerebral ischemia-reperfusion.	Oxygen	141-143	ribosomal protein S6 kinase B1	Rattus norvegicus	81-85
31350168-11	2019	CONCLUSION: This suggests that S6K1 inhibition is important for cell survival and that it reduces the number of small microregions with reduced local oxygen balance after cerebral ischemia-reperfusion.	Oxygen	150-156	ribosomal protein S6 kinase B1	Rattus norvegicus	31-35
17682093-4	2007	RESULTS: eNOS(-/-) mice had markedly lower energy expenditure (-10%, P &lt; 0.05) and oxygen consumption (-15%, P &lt; 0.05) than control mice.	Oxygen	86-92	nitric oxide synthase 3, endothelial cell	Mus musculus	9-13
31673566-4	2019	Data from two-photon phosphorescence lifetime microscopy indicate that old ATX mice had lower and more heterogeneous partial pressure of oxygen (  PO 2   ) in cortical tissue than young ATX mice.	Oxygen	137-143	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	75-78
17785431-7	2007	The switch of Hap1 from acting as a hypoxic repressor to an aerobic activator is determined by heme, which is synthesized only in the presence of oxygen.	Oxygen	146-152	Hap1p	Saccharomyces cerevisiae S288C	14-18
31673566-8	2019	Finally, dilation of capillaries in old ATX mice was observed, which suggests that capillaries play an active role in compensating for an oxygen deficit in brain tissue.	Oxygen	138-144	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	40-43
31201114-8	2019	Our results indicate that loss of Nf1 stimulates PKCdelta-mediated p47phox phosphorylation via RAS activation, leading to increased NADPH oxidase 2 activity, reactive oxygen species generation, membrane ruffling and macropinocytosis.	Oxygen	167-173	neurofibromin 1	Mus musculus	34-37
17658597-2	2007	The hypoxia inducible factors (HIFs) mediate the response to low oxygen, inducing genes such as insulin-like growth factor (IGF)-II.	Oxygen	65-71	insulin-like growth factor 2	Mus musculus	96-131
17658597-9	2007	Following 3 days exposure to low oxygen there was reduced EPC outgrowth, reduced Igf2 and increased Tpbp mRNA levels, suggesting commitment to the spongiotrophoblast lineage.	Oxygen	33-39	insulin-like growth factor 2	Mus musculus	81-85
17658597-12	2007	Furthermore, expression of Hif-2alpha and the HIF target genes: asHif-1alpha, Vegf and Slc2a1 were reduced under low oxygen with the addition of IGF-II.	Oxygen	117-123	endothelial PAS domain protein 1	Mus musculus	27-37
17658597-12	2007	Furthermore, expression of Hif-2alpha and the HIF target genes: asHif-1alpha, Vegf and Slc2a1 were reduced under low oxygen with the addition of IGF-II.	Oxygen	117-123	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	87-93
17658597-12	2007	Furthermore, expression of Hif-2alpha and the HIF target genes: asHif-1alpha, Vegf and Slc2a1 were reduced under low oxygen with the addition of IGF-II.	Oxygen	117-123	insulin-like growth factor 2	Mus musculus	145-151
31465212-3	2019	To identify the controlling features of S-site oxygen uptake, related Ni(mu-EPhX)(mu-S"N2)Fe (E = S or Se, Fe = (eta5-C5H5)FeII(CO)) complexes were electronically tuned by the para-substituent on mu-EPhX (X = CF3, Cl, H, OMe, NMe2) and compared in aspects of communication between Ni and Fe.	Oxygen	47-53	epoxide hydrolase 1	Homo sapiens	76-80
17658597-13	2007	In conclusion, Hif-1alpha and Hif-2alpha are differentially regulated by oxygen and IGF-II in cultured trophoblast cells and asHif-1alpha may mediate the response to prolonged hypoxia in murine trophoblasts.	Oxygen	73-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	15-25
17658597-13	2007	In conclusion, Hif-1alpha and Hif-2alpha are differentially regulated by oxygen and IGF-II in cultured trophoblast cells and asHif-1alpha may mediate the response to prolonged hypoxia in murine trophoblasts.	Oxygen	73-79	endothelial PAS domain protein 1	Mus musculus	30-40
31465212-5	2019	In the E = S, X = NMe2 case, the two-oxygen uptake complex was isolated and characterized as the sulfinato species with the second O of the O2SPh-NMe2 unit pointing out of the five-membered Ni-O-S-Fe-S" ring.	Oxygen	37-43	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	18-22
31465212-5	2019	In the E = S, X = NMe2 case, the two-oxygen uptake complex was isolated and characterized as the sulfinato species with the second O of the O2SPh-NMe2 unit pointing out of the five-membered Ni-O-S-Fe-S" ring.	Oxygen	37-43	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	146-150
17448532-0	2007	Hypoxia in the East China Sea: one of the largest coastal low-oxygen areas in the world.	Oxygen	62-68	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	26-29
17610874-4	2007	As compared to those of the simultaneous administration of normobaric air and lipopolysaccharide, administering hyperbaric oxygen or air plus lipopolysaccharide simultaneously had lesser febrile effects in terms of core temperature elevation, tumor necrosis factor-alpha overproduction and hypothalamic prostaglandin E(2) accumulation.	Oxygen	123-129	tumor necrosis factor	Oryctolagus cuniculus	243-270
17610874-6	2007	The results indicate that hyperbaric oxygen, and to some extent hyperbaric air, may cause prevention and suppression of pyrogenic fever by reducing overproduction of both circulating tumor necrosis factor-alpha and hypothalamic prostaglandin E(2).	Oxygen	37-43	tumor necrosis factor	Oryctolagus cuniculus	183-210
31465212-6	2019	Qualitative rates of reaction and ratios of oxygen-uptake products correlate with Hammett parameters of the X substituent on EPhX.	Oxygen	44-50	epoxide hydrolase 1	Homo sapiens	125-129
31281925-1	2019	Skp1 is hydroxylated by an O2-dependent prolyl hydroxylase (PhyA) that contributes to O2-sensing in the social amoeba Dictyostelium and the mammalian pathogen Toxoplasma gondii.	Oxygen	27-29	S-phase kinase associated protein 1	Homo sapiens	0-4
17827726-1	2007	Tyrosinase is a key enzyme for melanin biosynthesis and known to be sensitive to ultraviolet light in the presence of oxygen.	Oxygen	118-124	tyrosinase	Mus musculus	0-10
17629453-3	2007	While PKC gamma and PKC epsilon both help protect neural tissue from ischemia, PKC epsilon is the primary PKC isoform responsible for responding to decreased oxygen, or ischemia, in the heart.	Oxygen	158-164	protein kinase C epsilon	Homo sapiens	79-90
31281925-8	2019	These findings indicate a widespread occurrence of the Skp1 modification pathway across protist phylogeny, suggest that both Gnt1 and PhyA are specific for Skp1 and indicate that the second Skp1 provides a bypass mechanism for O2-regulation in Pythium and other protists that conserve this gene.	Oxygen	227-229	S-phase kinase associated protein 1	Homo sapiens	55-59
31506661-3	2019	Under alkaline condition, the C-CoP-1/12 exhibit splendid electrocatalytic performance with a low overpotential of 173 mV for hydrogen evolution reaction (HER) and 333 mV for oxygen evolution reaction (OER) at a current density of 10 mA cm-2.	Oxygen	175-181	caspase recruitment domain family member 16	Homo sapiens	32-35
17697160-3	2007	To test the hypothesis that MMP-and its inhibitor, tissue type inhibitor of matrix metalloproteinases (TIMP-1), could be related to functional status and prognosis in CHF, we examined the relationship of MMP-1 and TIMP-1 to peak oxygen consumption (VO2) and peak minute ventilation/carbon dioxide production relationship (VE/VCO2), and assessed their prognostic value.	Oxygen	229-235	matrix metallopeptidase 1	Homo sapiens	28-31
19535300-1	2009	In an effort to find conditions favouring bioelectrocatalytic reduction of oxygen by surface-immobilised human ceruloplasmin (Cp), direct electron transfer (DET) reactions between Cp and an extended range of surfaces were considered.	Oxygen	75-81	ceruloplasmin	Homo sapiens	111-124
31436433-5	2019	Nevertheless, the response of Pd nanowires being extremely effected by O2 in air due to the competitive adsorption on the surface of Pd nanostructures as well as the reaction between chemisorbed O (Pd-O) and adsorbed dihydrogen lead to a decrease in H absorption into PdHx and poor sensing responses under low target concentration.	Oxygen	71-73	pyruvate dehydrogenase complex component X	Homo sapiens	268-272
17805094-2	2007	The dominant paradigm is that the improved performance at sea level is due primarily to an accelerated erythropoietic response due to the reduced oxygen available at altitude, leading to an increase in red cell mass, maximal oxygen uptake, and competitive performance.	Oxygen	146-152	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
17805094-2	2007	The dominant paradigm is that the improved performance at sea level is due primarily to an accelerated erythropoietic response due to the reduced oxygen available at altitude, leading to an increase in red cell mass, maximal oxygen uptake, and competitive performance.	Oxygen	225-231	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	58-61
19575748-4	2009	PHDs tag HIF-1alpha subunits for polyubiquitination and proteasomal degradation by prolyl hydroxylation using 2-oxoglutarate (2-OX) and dioxygen.	Oxygen	136-144	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-19
32015809-3	2019	Computational simulation and isotope tracing experiments showed that the mu4-OH group of the {Co8(mu4-OH)6} unit participates in the water oxidation reaction to offer an oxygen vacancy site with near-optimal OH- adsorption energy.	Oxygen	170-176	adaptor related protein complex 4 subunit mu 1	Homo sapiens	73-76
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Oxygen	206-212	complement C4A (Rodgers blood group)	Homo sapiens	351-354
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Oxygen	206-212	complement C5	Homo sapiens	359-362
17556599-3	2007	In contrast, 20% oxygen caused a rapid decrease in hypoxia-inducible factor 1alpha and nucleophosmin, followed by the induction of p53 and apoptosis of cells.	Oxygen	17-23	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-82
17556599-3	2007	In contrast, 20% oxygen caused a rapid decrease in hypoxia-inducible factor 1alpha and nucleophosmin, followed by the induction of p53 and apoptosis of cells.	Oxygen	17-23	nucleophosmin 1	Mus musculus	87-100
17556599-3	2007	In contrast, 20% oxygen caused a rapid decrease in hypoxia-inducible factor 1alpha and nucleophosmin, followed by the induction of p53 and apoptosis of cells.	Oxygen	17-23	transformation related protein 53, pseudogene	Mus musculus	131-134
32015809-3	2019	Computational simulation and isotope tracing experiments showed that the mu4-OH group of the {Co8(mu4-OH)6} unit participates in the water oxidation reaction to offer an oxygen vacancy site with near-optimal OH- adsorption energy.	Oxygen	170-176	adaptor related protein complex 4 subunit mu 1	Homo sapiens	98-101
31500245-5	2019	Using a reporter construct containing the oxygen-dependent degradation (ODD) domain of HIF-1alpha and a fluorogenic proteasome substrate in combination with SHP-2 mutant constructs, we show that SHP-2 inhibits the 26S proteasome activity in endothelial cells under hypoxic conditions in vitro via Src kinase/p38 mitogen-activated protein kinase (MAPK) signalling.	Oxygen	42-48	hypoxia inducible factor 1, alpha subunit	Mus musculus	87-97
17893650-12	2007	We conclude that ARBP and HPRT exhibit expression that is sufficiently stable under conditions of varying oxygen tension, to permit their use as housekeeping genes in at least one model of OIR in the neonatal rat.	Oxygen	106-112	ribosomal protein lateral stalk subunit P0	Rattus norvegicus	17-21
19515792-2	2009	Improved oxygen homeostasis, a well-established consequence of EPOR activation, is very important for human skeletal muscle performance.	Oxygen	9-15	erythropoietin receptor	Homo sapiens	63-67
19500668-4	2009	The enzyme activity toward single oxygen-induced DNA damage and mRNA expression levels of Ercc1, Neil1, and Ogg1 remained unaltered with age.	Oxygen	34-40	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	90-95
19542903-3	2009	Exposure to 60% O2 for 14 d caused pulmonary neutrophil and macrophage influx, increased tissue fraction and tyrosine nitration, reduced VEGF-A and angiopoietin-1 expression, and reduced small vessel (20-65 microm) and alveolar numbers.	Oxygen	16-18	vascular endothelial growth factor A	Rattus norvegicus	137-143
19542903-3	2009	Exposure to 60% O2 for 14 d caused pulmonary neutrophil and macrophage influx, increased tissue fraction and tyrosine nitration, reduced VEGF-A and angiopoietin-1 expression, and reduced small vessel (20-65 microm) and alveolar numbers.	Oxygen	16-18	angiopoietin 1	Rattus norvegicus	148-162
17573206-0	2007	On optima: the case of myoglobin-facilitated oxygen diffusion.	Oxygen	45-51	myoglobin	Homo sapiens	23-32
17573206-1	2007	The process of myoglobin/leghemoglobin-facilitated oxygen diffusion is adapted to function in different environments in diverse organisms.	Oxygen	51-57	myoglobin	Homo sapiens	15-24
17652159-7	2007	Some motor, centrosome and kinetochore proteins (dynein, Kin-8, Cnn, TACC, Cenp-C, Nuf2) are rapidly relocalized after oxygen deprivation.	Oxygen	119-125	Cytoplasmic dynein light chain 2	Drosophila melanogaster	49-55
31066901-0	2019	Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.	Oxygen	96-102	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-39
17646578-1	2007	BACKGROUND: Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF)-alpha subunits.	Oxygen	94-100	egl-9 family hypoxia-inducible factor 1	Mus musculus	70-74
17646578-1	2007	BACKGROUND: Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF)-alpha subunits.	Oxygen	94-100	egl-9 family hypoxia-inducible factor 3	Mus musculus	80-84
19498059-3	2009	A complex of heme oxygenase-2 (HO-2) and the BK channel has been suggested as a universal oxygen sensor system.	Oxygen	18-24	heme oxygenase 2	Mus musculus	31-35
19535330-9	2009	In summary, this article uncovers a protective role for astrocyte S6K1 against brain ischemia, indicating a functional pathway that senses nutrient and oxygen levels and may be beneficial for neuronal survival.	Oxygen	152-158	ribosomal protein S6 kinase B1	Homo sapiens	66-70
31066901-2	2019	We hypothesized non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could be performed using a new pH- and oxygen-sensitive molecular MRI technique.	Oxygen	143-149	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	84-88
17625884-7	2007	The introduction of oxygen functionality at C-1 in all these natural products was accomplished by photooxygenation under a positive pressure of oxygen.	Oxygen	20-26	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	44-47
31483963-7	2019	RESULTS: The change in the mean (+-SD) alveolar-arterial oxygen gradient was significantly better in the GM-CSF group (33 patients) than in the placebo group (30 patients) (mean change from baseline, -4.50+-9.03 mm Hg vs. 0.17+-10.50 mm Hg; P = 0.02).	Oxygen	57-63	colony stimulating factor 2	Homo sapiens	105-111
17625884-7	2007	The introduction of oxygen functionality at C-1 in all these natural products was accomplished by photooxygenation under a positive pressure of oxygen.	Oxygen	103-109	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	44-47
19731845-1	2009	Near-infrared spectroscopy (NIRS) assesses cerebral oxygen saturation (Sco2) as a balance between cerebral oxygen delivery and consumption.	Oxygen	52-58	synthesis of cytochrome C oxidase 2	Homo sapiens	71-75
19731845-1	2009	Near-infrared spectroscopy (NIRS) assesses cerebral oxygen saturation (Sco2) as a balance between cerebral oxygen delivery and consumption.	Oxygen	107-113	synthesis of cytochrome C oxidase 2	Homo sapiens	71-75
17635546-3	2007	Using this novel approach, we separately quantified the activity of the major players in the oxygen cycle in a hypersaline microbial mat: gross photosynthesis of cyanobacteria, NIR light-dependent respiration of Chloroflexus-like bacteria (CLB) and respiration of aerobic heterotrophs.	Oxygen	93-99	citramalyl-CoA lyase	Homo sapiens	212-238
31483963-10	2019	CONCLUSIONS: In this randomized, controlled trial, inhaled recombinant human GM-CSF was associated with a modest salutary effect on the laboratory outcome of arterial oxygen tension, and no clinical benefits were noted.	Oxygen	167-173	colony stimulating factor 2	Homo sapiens	77-83
17635546-3	2007	Using this novel approach, we separately quantified the activity of the major players in the oxygen cycle in a hypersaline microbial mat: gross photosynthesis of cyanobacteria, NIR light-dependent respiration of Chloroflexus-like bacteria (CLB) and respiration of aerobic heterotrophs.	Oxygen	93-99	citramalyl-CoA lyase	Homo sapiens	240-243
19656486-1	2009	Two studies (Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2alpha is a major player in regulating iron absorption by directly controlling the transcription of iron transporters in the intestine in response to changes in mucosal iron or oxygen levels.	Oxygen	281-287	endothelial PAS domain protein 1	Homo sapiens	100-110
31411035-1	2019	Herein, a ternary electrochemiluminescence (ECL) sensing platform with high luminous efficiency was established for ultrasensitive bioanalysis of the microRNA-21 (miR-21) from cancer cell based on N-(aminobutyl)-N-(ethylisoluminol) (ABEI) as ECL emitter, dissolved O2 as coreactant, and silver bismuth oxide nanocrystals (Ag3BiO3 NCs) as coreaction accelerator.	Oxygen	265-267	microRNA 21	Homo sapiens	150-161
19302442-6	2009	RESULTS: Exposure of primary mouse hepatocytes to 1% oxygen stimulated nuclear accumulation of HIF-1alpha and upregulated PAI-1, vascular endothelial cell growth factor and the vasoactive peptides adrenomedullin-1 (ADM-1) and ADM-2.	Oxygen	53-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	95-105
17553943-0	2007	Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.	Oxygen	13-15	carbonic anhydrase 1	Rattus norvegicus	33-36
19302442-6	2009	RESULTS: Exposure of primary mouse hepatocytes to 1% oxygen stimulated nuclear accumulation of HIF-1alpha and upregulated PAI-1, vascular endothelial cell growth factor and the vasoactive peptides adrenomedullin-1 (ADM-1) and ADM-2.	Oxygen	53-59	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	122-127
31411035-1	2019	Herein, a ternary electrochemiluminescence (ECL) sensing platform with high luminous efficiency was established for ultrasensitive bioanalysis of the microRNA-21 (miR-21) from cancer cell based on N-(aminobutyl)-N-(ethylisoluminol) (ABEI) as ECL emitter, dissolved O2 as coreactant, and silver bismuth oxide nanocrystals (Ag3BiO3 NCs) as coreaction accelerator.	Oxygen	265-267	microRNA 21	Homo sapiens	163-169
19302442-8	2009	Exposure of HIF-1alpha-deficient hepatocytes to 1% oxygen only partially prevented upregulation of these genes, suggesting that other hypoxia-regulated transcription factors, such as HIF-2alpha, may also regulate these genes.	Oxygen	51-57	endothelial PAS domain protein 1	Mus musculus	183-193
17371947-5	2007	Consistent with the role of GSK3b in destabilizing beta-catenin, there was more cytoplasmic beta-catenin in UC-HPCs exposed to 2% to 3% O(2) on fibronectin, compared with suspension culture.	Oxygen	136-140	catenin beta 1	Homo sapiens	92-104
17371947-6	2007	UC-HPCs cultured at 2% to 3% O(2) with OB factors showed an increase in nuclear beta-catenin and persistence of a small pool of CD34(+)38(-) HPCs.	Oxygen	29-33	catenin beta 1	Homo sapiens	80-92
17481694-8	2007	Generation of 3-OH-B(a)P in group II implicates the possibility of reactive oxygen species (O2- and H2O2) production in haemolysates during cytochrome P4501A1 (CYP1A1) mediated Phase-I-metabolism.	Oxygen	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
19302442-9	2009	In support of this, HIF-2alpha was activated in hypoxic hepatocytes, and exposure of HIF-1beta-deficient hepatocytes to 1% oxygen completely prevented upregulation of PAI-1, vascular endothelial cell growth factor and ADM-1, suggesting that HIF-2alpha may also contribute to upregulation of these genes in hypoxic hepatocytes.	Oxygen	123-129	endothelial PAS domain protein 1	Mus musculus	20-30
19302442-9	2009	In support of this, HIF-2alpha was activated in hypoxic hepatocytes, and exposure of HIF-1beta-deficient hepatocytes to 1% oxygen completely prevented upregulation of PAI-1, vascular endothelial cell growth factor and ADM-1, suggesting that HIF-2alpha may also contribute to upregulation of these genes in hypoxic hepatocytes.	Oxygen	123-129	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	167-172
19302442-9	2009	In support of this, HIF-2alpha was activated in hypoxic hepatocytes, and exposure of HIF-1beta-deficient hepatocytes to 1% oxygen completely prevented upregulation of PAI-1, vascular endothelial cell growth factor and ADM-1, suggesting that HIF-2alpha may also contribute to upregulation of these genes in hypoxic hepatocytes.	Oxygen	123-129	endothelial PAS domain protein 1	Mus musculus	241-251
19390487-3	2009	Prolonged exposure of fetal ductus to PGE2 in vitro increased the expression of CaL- and K+-channel genes (CaLalpha1c, CaLbeta2, Kir6.1, and Kv1.5, which regulate oxygen-induced constriction) without affecting the genes that regulate Rho-kinase-mediated calcium sensitization.	Oxygen	163-169	potassium inwardly-rectifying channel, subfamily J, member 8	Mus musculus	129-135
31237976-10	2019	S100A8-induced IL-8 secretion was dependent on receptor RAGE, AP-1 activation, and reactive oxygen species production.	Oxygen	92-98	S100 calcium binding protein A8	Bos taurus	0-6
19465554-1	2009	Given that the physiology of heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2max)) in humans.	Oxygen	34-40	heme oxygenase 1	Homo sapiens	47-51
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Oxygen	175-181	cytochrome b5 type A	Homo sapiens	21-27
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Oxygen	175-181	cytochrome b5 type A	Homo sapiens	62-68
31170519-2	2019	Evidence from our preclinical work in an umbilical cord blood (UCB) transplantation murine model suggests that treatment with hyperbaric oxygen (HBO) before UCB infusion improves UCB CD34+ cell engraftment by reducing erythropoietin levels.	Oxygen	137-143	erythropoietin	Mus musculus	218-232
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Oxygen	175-181	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	102-108
19614926-0	2009	Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen.	Oxygen	0-6	aquaporin 3 (Gill blood group)	Homo sapiens	182-193
19614926-6	2009	The keratinocyte adherens junction proteins E-cadherin and beta-catenin were dramatically decreased in a regio-specific manner throughout the epidermis following oxygen deprivation.	Oxygen	162-168	catenin beta 1	Homo sapiens	59-71
19614926-10	2009	These results show that oxygen deprivation and reoxygenation exert differential effects on epidermal adhesion proteins and suggest a novel role for cadherins, beta-catenin, and Slug in hypoxia-induced junctional changes occurring in stratified squamous epithelium.	Oxygen	24-30	catenin beta 1	Homo sapiens	159-171
31260338-8	2019	Serum erythropoietin (EPO) levels were increased significantly in young mice receiving low-oxygen SIHT treatments (10% and 15% oxygen).	Oxygen	91-97	erythropoietin	Mus musculus	6-20
19375411-2	2009	Its activity in potato tuber (Solanum tuberosum L.) was induced following chilling treatment at 4 degrees C. About half of the total O(2) consumption of succinate oxidation in such mitochondria was found to be sensitive to SHAM, a known inhibitor of AOX activity.	Oxygen	133-137	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	250-253
19375411-3	2009	Addition of catalase to the reaction mixture of AOX during the reaction decreased the rate of SHAM-sensitive oxygen consumption by nearly half, and addition at the end of the reaction released nearly half of the consumed oxygen by AOX, both typical of catalase action on H(2)O(2).	Oxygen	109-115	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	48-51
17953812-6	2007	The purpose of this study was to investigate the expression of VEGF and its receptors in premature lungs of rats with intra-amniotic endotoxin priming and/or exposed to 60% O2 and to elucidate the relationship between intrauterine inflammatory/chronic high O2 exposure and the pathogenesis of BPD.	Oxygen	173-175	vascular endothelial growth factor A	Rattus norvegicus	63-67
17953812-6	2007	The purpose of this study was to investigate the expression of VEGF and its receptors in premature lungs of rats with intra-amniotic endotoxin priming and/or exposed to 60% O2 and to elucidate the relationship between intrauterine inflammatory/chronic high O2 exposure and the pathogenesis of BPD.	Oxygen	257-259	vascular endothelial growth factor A	Rattus norvegicus	63-67
31260338-8	2019	Serum erythropoietin (EPO) levels were increased significantly in young mice receiving low-oxygen SIHT treatments (10% and 15% oxygen).	Oxygen	91-97	erythropoietin	Mus musculus	22-25
19382760-3	2009	The resulting achiral [Cu(pht)(dpk)](n) helices are conjoined by bridging phthalate carboxylate oxygen atoms to construct {Cu(2)O(2)} dimeric units, which serve as 8-connected nodes for a three-dimensional (3D) coordination polymer lattice with an unprecedented 3(6)4(12)5(8)6(2) topology, evocative of a 3D Kagome lattice.	Oxygen	96-102	potassium two pore domain channel subfamily K member 1	Homo sapiens	31-34
31260338-8	2019	Serum erythropoietin (EPO) levels were increased significantly in young mice receiving low-oxygen SIHT treatments (10% and 15% oxygen).	Oxygen	127-133	erythropoietin	Mus musculus	6-20
17311997-1	2007	Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin.	Oxygen	22-28	myoglobin	Homo sapiens	124-133
31260338-8	2019	Serum erythropoietin (EPO) levels were increased significantly in young mice receiving low-oxygen SIHT treatments (10% and 15% oxygen).	Oxygen	127-133	erythropoietin	Mus musculus	22-25
17311997-1	2007	Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin.	Oxygen	85-91	myoglobin	Homo sapiens	124-133
17311997-2	2007	An interaction between iron homeostasis and oxygen regulation is further suggested during hypoxia, in which hemoglobin and myoglobin syntheses have been reported to increase.	Oxygen	44-50	myoglobin	Homo sapiens	123-132
17293486-0	2007	Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases.	Oxygen	0-6	thioredoxin	Homo sapiens	48-59
17293486-11	2007	Here we discuss the roles of TRX on oxygen stress and redox regulation from different perspectives, in embryogenesis and in adult diseases focusing on cardiac disorders.	Oxygen	36-42	thioredoxin	Homo sapiens	29-32
18420720-9	2009	These data suggest that many of the skeletal muscle structural and functional adaptations enabling greater O(2) utilization in HCR at G7 continue to progress following additional selective breeding for endurance capacity.	Oxygen	107-111	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	127-130
19500451-5	2009	IGF-1"s therapeutic effects likely involve its ability to prevent delayed apoptosis, as we demonstrated in primary cortical neuronal cultures under oxygen and glucose deprivation.	Oxygen	148-154	insulin-like growth factor 1	Rattus norvegicus	0-5
31373011-5	2019	PHD is an oxygen-dependent enzyme and therefore is inactivated in hypoxia, in turn resulting in HIF-1alpha stabilization, its dimerization with HIF-1beta subunit thereby producing the transcriptionally active factor.	Oxygen	10-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
21706669-4	2009	The investigations show that the "pen" actually is a small oxygen bubble between the counter electrode and the sample surface.	Oxygen	59-65	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	34-37
17382973-0	2007	Cannabinoid modulation of neuronal function after oxygen/glucose deprivation in area CA1 of the rat hippocampus.	Oxygen	50-56	carbonic anhydrase 1	Rattus norvegicus	85-88
31325555-1	2019	AIM: To evaluate the Inadequate oxygen delivery (IDO2) index dose as a predictor of cardiac arrest (CA) in neonates following congenital heart surgery.	Oxygen	32-38	indoleamine 2,3-dioxygenase 2	Homo sapiens	49-53
17672171-9	2007	CONCLUSIONS: Three main gender differences are observed in tissue gas loading and unloading under hyperbaric oxygen exposures: Females release SC N2 more slowly and saturate MM O2 and SC O2 to greater extents.	Oxygen	109-115	synthesis of cytochrome C oxidase 2	Homo sapiens	184-189
19277991-8	2009	EP1 expression was significantly increased in cells cultured in 21% oxygen with DMOG or PHD2 siRNA treatment compared to controls.	Oxygen	68-74	prostaglandin E receptor 1	Homo sapiens	0-3
19304944-9	2009	We find that tsp1(-/-), fyn(-/-), and double-mutant tsp1(-/-)/fyn(-/-) mice have a similar enhancement of capillary survival in oxygen, whereas in a tsp(-/-) background, the loss of only one allele of src restores the balance in survival and apoptosis to that of wild-type mice.	Oxygen	128-134	tumor suppressor region 1	Mus musculus	13-17
31467345-1	2019	Sea-level change is an important parameter controlling the expansion of oxygen-depleted conditions in neritic settings during oceanic anoxic events (OAEs).	Oxygen	72-78	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
19304944-9	2009	We find that tsp1(-/-), fyn(-/-), and double-mutant tsp1(-/-)/fyn(-/-) mice have a similar enhancement of capillary survival in oxygen, whereas in a tsp(-/-) background, the loss of only one allele of src restores the balance in survival and apoptosis to that of wild-type mice.	Oxygen	128-134	tumor suppressor region 1	Mus musculus	52-56
19208652-4	2009	With increasing mutant ND5 mtDNA content, respiratory function including oxygen consumption and ATP generation through oxidative phosphorylation declined progressively, while lactate production and dependence on glucose increased.	Oxygen	73-79	mitochondrially encoded NADH dehydrogenase 5	Homo sapiens	23-26
17391033-3	2007	In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen.	Oxygen	130-136	C-C motif chemokine ligand 2	Homo sapiens	45-49
17391033-6	2007	It appears possible that CCl2 is rapidly captured by oxygen to afford a chromophoric dichlorocarbene carbonyl oxide.	Oxygen	53-59	C-C motif chemokine ligand 2	Homo sapiens	25-29
17404509-6	2007	Finally, we also discuss the observations that the oxygen-sensitive HIF-2alpha subunit is accumulated and active under non-hypoxic conditions as exemplified by HIF-2alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well-vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.	Oxygen	51-57	endothelial PAS domain protein 1	Homo sapiens	68-78
17404509-6	2007	Finally, we also discuss the observations that the oxygen-sensitive HIF-2alpha subunit is accumulated and active under non-hypoxic conditions as exemplified by HIF-2alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well-vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.	Oxygen	51-57	endothelial PAS domain protein 1	Homo sapiens	160-170
31407761-2	2019	DAAO catalyses hydride transfer from the substrate to the flavin in the reductive half-reaction, and the flavin is reoxidized by O2 in the oxidative half-reaction.	Oxygen	129-131	D-amino acid oxidase	Homo sapiens	0-4
17179152-0	2007	Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage.	Oxygen	0-6	insulin receptor substrate 1	Homo sapiens	42-70
17179152-0	2007	Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage.	Oxygen	0-6	insulin receptor substrate 1	Homo sapiens	72-77
19301222-0	2009	Association of GNB3 C825T polymorphism with peak oxygen consumption.	Oxygen	49-55	G protein subunit beta 3	Homo sapiens	15-19
19358330-9	2009	FGFR2-Tg-ECs exposed to 1% oxygen exhibited enhanced phosphorylation of 416-Tyr-Src, 473-Ser-Akt, and HIF1alpha accumulation.	Oxygen	27-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	102-111
19358330-10	2009	The production of FGF2 was enhanced 2.1-fold in FGFR-Tg-ECs under 1% oxygen via the Src/Akt/HIF1alpha pathway, which induced the peri-vessel migration of vascular smooth muscle cells (VSMCs) and anti-apoptotic effects on VSMCs and cardiomyocytes.	Oxygen	69-75	Rous sarcoma oncogene	Mus musculus	84-87
19358330-10	2009	The production of FGF2 was enhanced 2.1-fold in FGFR-Tg-ECs under 1% oxygen via the Src/Akt/HIF1alpha pathway, which induced the peri-vessel migration of vascular smooth muscle cells (VSMCs) and anti-apoptotic effects on VSMCs and cardiomyocytes.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	92-101
31555141-2	2019	It has been widely reported that Trx2 deletion in cells or mice generates massive reactive oxygen species (ROS) which have been implicated in many pathological processes.	Oxygen	91-97	thioredoxin 2	Mus musculus	33-37
19251694-11	2009	SEPT9_v1 also protected HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation.	Oxygen	167-173	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
17179152-5	2007	Our findings indicate that transient hypoxia (1% oxygen) leads to caspase-mediated cleavage of IRS-1 without inducing cell death.	Oxygen	49-55	insulin receptor substrate 1	Homo sapiens	95-100
31993422-3	2019	Objective: To determine whether oxygen supplementation via a nasal trumpet connected to a Mapleson B circuit (NTM) was effective in decreasing hypoxic events when compared with the standard of care, oxygen supplementation with a nasal cannula (NC).	Oxygen	32-38	neurotrimin	Homo sapiens	110-113
17114245-1	2007	Although it has been shown that endothelial nitric oxide synthase (eNOS)-derived nitric oxide downregulates mitochondrial oxygen consumption during early reperfusion, its effects on inducible NOS (iNOS) induction and myocardial injury during late reperfusion are unknown.	Oxygen	122-128	nitric oxide synthase 3, endothelial cell	Mus musculus	32-65
17197388-2	2007	Plasminogen activator inhibitor-1 (PAI-1) is an important factor suppressing fibrinolysis under conditions of low oxygen tension.	Oxygen	114-120	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-33
17197388-2	2007	Plasminogen activator inhibitor-1 (PAI-1) is an important factor suppressing fibrinolysis under conditions of low oxygen tension.	Oxygen	114-120	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	35-40
17267736-8	2007	Taken together, these data reveal what is believed to be a previously unrecognized role of CD73 in renal protection from ischemia and suggest treatment with soluble 5"-nucleotidase as a novel therapeutic approach in the treatment of renal diseases that are precipitated by limited oxygen availability.	Oxygen	281-287	5' nucleotidase, ecto	Mus musculus	91-95
17267736-8	2007	Taken together, these data reveal what is believed to be a previously unrecognized role of CD73 in renal protection from ischemia and suggest treatment with soluble 5"-nucleotidase as a novel therapeutic approach in the treatment of renal diseases that are precipitated by limited oxygen availability.	Oxygen	281-287	5' nucleotidase, ecto	Mus musculus	165-180
17217981-3	2007	Of the biomass characteristics studied, only solids concentration (correlated with viscosity), the carbohydrate fraction of the EPS (EPS(c)) and the chemical oxygen demand (COD) concentration of the SMP (SMP(COD)) were found to affect the oxygen transfer parameters k(L)a(20) (the oxygen transfer coefficient) and alpha-factor.	Oxygen	158-164	family with sequence similarity 53 member B	Homo sapiens	199-202
19331391-3	2009	Increasing size of the substituents at C-1 and C-5 of the diene favors kinetic products arising from oxygen addition at the nonconjugated position, C-3, of the pentadienyl radical intermediate.	Oxygen	101-107	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	39-50
19331391-4	2009	Substituents at C-1 or C-5 of the pentadienyl radical also have a significant effect on the regioselectivity of the conjugated diene hydroperoxides formed, larger substituents directing oxygen addition to the pentadienyl radical at the site of least steric hindrance.	Oxygen	186-192	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	16-19
19331391-4	2009	Substituents at C-1 or C-5 of the pentadienyl radical also have a significant effect on the regioselectivity of the conjugated diene hydroperoxides formed, larger substituents directing oxygen addition to the pentadienyl radical at the site of least steric hindrance.	Oxygen	186-192	complement C5	Homo sapiens	23-26
19331391-6	2009	Groups at C-1 and C-5 of the diene can influence product distribution based upon (a) steric demand in the oxygen-radical reaction and (b) the influence of substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products.	Oxygen	106-112	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	10-21
18821853-0	2009	Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2.	Oxygen	11-17	discoidin domain receptor tyrosine kinase 2	Rattus norvegicus	28-55
17217981-3	2007	Of the biomass characteristics studied, only solids concentration (correlated with viscosity), the carbohydrate fraction of the EPS (EPS(c)) and the chemical oxygen demand (COD) concentration of the SMP (SMP(COD)) were found to affect the oxygen transfer parameters k(L)a(20) (the oxygen transfer coefficient) and alpha-factor.	Oxygen	239-245	family with sequence similarity 53 member B	Homo sapiens	199-202
31993422-17	2019	Conclusion: For patients undergoing EBUS with MAC, oxygen supplementation with NTM significantly decreased the incidence of hypoxic events when compared with NC.	Oxygen	51-57	neurotrimin	Homo sapiens	79-82
19437988-3	2009	The Mb-loaded films at pyrolytic graphite (PG) electrodes, designated as {PA/ZrO2}n-Mb, demonstrated well-defined and quasi-reversible CV responses for Mb Fe(III)/Fe(II) redox couple and good electrocatalytic properties toward oxygen and H2O2.	Oxygen	227-233	myoglobin	Homo sapiens	4-6
31142511-7	2019	SIGNIFICANCE: This study provides unprecedented evidence for an oxygen-independent mechanism of PHD2 regulation that has important implications in cancer cell survival.	Oxygen	64-70	egl-9 family hypoxia-inducible factor 1	Mus musculus	96-100
19166505-9	2009	Human 3K3A-APC had by fivefold greater cytoprotective activity than murine 3K3A-APC in oxygen-glucose deprivation model in human brain endothelial cells, whereas murine 3K3A-APC was by 2.5-fold more potent than human 3K3A-APC in a mouse model of NMDA-induced neuronal apoptosis.	Oxygen	87-93	APC, WNT signaling pathway regulator	Mus musculus	80-83
19166505-9	2009	Human 3K3A-APC had by fivefold greater cytoprotective activity than murine 3K3A-APC in oxygen-glucose deprivation model in human brain endothelial cells, whereas murine 3K3A-APC was by 2.5-fold more potent than human 3K3A-APC in a mouse model of NMDA-induced neuronal apoptosis.	Oxygen	87-93	APC, WNT signaling pathway regulator	Mus musculus	80-83
17175112-9	2007	Imaging analyses of cortical slices exposed briefly to oxygen and glucose deprivation (OGD) revealed a substantial number of damaged cells (propidium iodide-labeled) in the Kir6.2(-/-) OGD group, but few degenerating neurons in the wildtype OGD group, or in the wildtype and Kir6.2(-/-) control groups.	Oxygen	55-61	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	173-179
17071723-7	2007	Exposure of primary lung fibroblasts to 85% O(2) significantly enhanced the TGF-beta-stimulated production of the alpha(1) subunit of type I collagen (Ialpha(1)), tissue inhibitor of metalloproteinase-1, tropoelastin, and tenascin-C.	Oxygen	44-48	elastin	Mus musculus	204-216
17272254-7	2007	When breathing O2 at 10 L.min-1, the F(ETO2) values after three minutes were similar with the Mapleson A, circle, and Mapleson D breathing systems (91.8+/-2.3%, 91.2+/-1.7%, 90.6+/-2.7%, respectively).	Oxygen	15-17	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	39-43
19267931-8	2009	Gene silencing of p21 and p27 promoted DNA synthesis at ambient oxygen concentrations.	Oxygen	64-70	interferon alpha inducible protein 27	Homo sapiens	26-29
31111864-2	2019	Although endothelin-1 (ET-1) plays an important role in vascular inflammation and reactive oxygen species production, the individual effect of ET-1 in atherogenesis remains unclear.	Oxygen	91-97	endothelin 1	Mus musculus	9-21
19223594-2	2009	This is the case when a rhodium nanosized crystal--conditioned as a field emitter tip--is exposed to hydrogen and oxygen.	Oxygen	114-120	TOR signaling pathway regulator	Homo sapiens	82-85
17328680-9	2007	The arterial oxygen tension and the survival rate were significantly higher in the KGF-transfected group.	Oxygen	13-19	fibroblast growth factor 7	Mus musculus	83-86
31111864-2	2019	Although endothelin-1 (ET-1) plays an important role in vascular inflammation and reactive oxygen species production, the individual effect of ET-1 in atherogenesis remains unclear.	Oxygen	91-97	endothelin 1	Mus musculus	23-27
31070932-9	2019	These data identify a key role for AMPK-NKCC1 interaction as a point of convergence for suppression of colonic epithelial ion transport by inflammatory reactive oxygen species.NEW & NOTEWORTHY H2O2 inhibition of intestinal epithelial Ca2+-dependent Cl- secretion involves recruitment of AMP-activated protein kinase (AMPK) downstream of ERK and phosphatidylinositol 3-kinase signaling pathways, physical interaction of AMPK with the Na+-K+-2Cl- cotransporter NKCC1, and AMPK-dependent suppression of NKCC1-mediated electrolyte influx without causing NKCC1 internalization.	Oxygen	161-167	solute carrier family 12 member 2	Homo sapiens	40-45
17289480-1	2007	OBJECTIVE: The goal of this study was to evaluate the efficacy of 100% oxygen and inhaled nitric oxide (iNO) in decreasing pulmonary vascular resistance (PVR) and transpulmonary gradient (TPG) in dilated cardiomyopathy patients being evaluated for orthotopic heart transplantation (OHT); who, despite maximal intravenous (IV) dilator therapy, had persistent moderate-to-severe pulmonary hypertension.	Oxygen	71-77	PVR cell adhesion molecule	Homo sapiens	154-157
17295437-11	2007	IL-1 decreased both proteoglycan and collagen II synthesis in cartilage explants in 1% O2 or 20% O2, but MnTE-2-PyP5+ did not prevent these anti-anabolic effects.	Oxygen	87-89	interleukin 1 alpha	Homo sapiens	0-4
17295437-11	2007	IL-1 decreased both proteoglycan and collagen II synthesis in cartilage explants in 1% O2 or 20% O2, but MnTE-2-PyP5+ did not prevent these anti-anabolic effects.	Oxygen	97-99	interleukin 1 alpha	Homo sapiens	0-4
17295437-13	2007	CONCLUSION: Our findings show that oxygen tension alters IL-1-induced peroxynitrite formation, which can influence proteoglycan degradation.	Oxygen	35-41	interleukin 1 alpha	Homo sapiens	57-61
18776134-6	2009	In control small airway epithelial cells exposed to H(2)O(2) or in wild-type mice exposed to 100% oxygen, a marked induction of ASK-1 and pJun N-terminal kinase was observed.	Oxygen	98-104	mitogen-activated protein kinase kinase kinase 5	Mus musculus	128-133
18776134-8	2009	In addition, IL-6 Tg(+) mice exposed to 100% oxygen exhibited reduced ASK-1 levels and enhanced SOCS-1 expression compared with wild-type mice.	Oxygen	45-51	mitogen-activated protein kinase kinase kinase 5	Mus musculus	70-75
19017876-8	2009	In probands from the Boston Early-Onset COPD Study, SNPs in EPHX1 and in SERPINE2 were associated with the requirement for supplemental oxygen.	Oxygen	136-142	epoxide hydrolase 1	Homo sapiens	60-65
19017876-8	2009	In probands from the Boston Early-Onset COPD Study, SNPs in EPHX1 and in SERPINE2 were associated with the requirement for supplemental oxygen.	Oxygen	136-142	serpin family E member 2	Homo sapiens	73-81
17313273-6	2007	Oxygen cost decreased significantly by 6% (p &lt; or = 0.05) only for CAR, whereas the respiratory exchange ratio decreased significantly (p &lt; or = 0.05) for both WLK (0.84-0.81) and STR (0.87-0.83), and heart rate decreased significantly (p &lt; or = 0.05) only for CAR.	Oxygen	0-6	CXADR pseudogene 1	Homo sapiens	70-73
19023330-4	2009	We also show that loss of HtrA2 results in the accumulation of unfolded proteins in the mitochondria, defective mitochondrial respiration and enhanced production of reactive oxygen species that contribute to the induction of CHOP expression and to neuronal cell death.	Oxygen	174-180	HtrA serine peptidase 2	Homo sapiens	26-31
31120770-2	2019	Although postconditioning with 8% oxygen can alleviate transient global cerebral ischemia (tGCI)-induced neuronal damage in hippocampal CA1 subregion in adult rats as demonstrated by our previous studies, little is understood about the role of Wnt/beta-catenin pathway in hypoxic postconditioning (HPC)-induced neuroprotection.	Oxygen	34-40	carbonic anhydrase 1	Rattus norvegicus	136-139
19237917-12	2009	Oxygen therapy increased enterocyte proliferation in the ileum, and diminished both the apoptosis index and Bax gene expression in the jejunum and ileum (p &lt; 0.05).	Oxygen	0-6	BCL2 associated X, apoptosis regulator	Rattus norvegicus	108-111
17169462-0	2007	Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson"s disease.	Oxygen	46-52	phosphatase and tensin homolog	Homo sapiens	15-19
31120770-2	2019	Although postconditioning with 8% oxygen can alleviate transient global cerebral ischemia (tGCI)-induced neuronal damage in hippocampal CA1 subregion in adult rats as demonstrated by our previous studies, little is understood about the role of Wnt/beta-catenin pathway in hypoxic postconditioning (HPC)-induced neuroprotection.	Oxygen	34-40	Wnt family member 2	Rattus norvegicus	244-247
31120770-2	2019	Although postconditioning with 8% oxygen can alleviate transient global cerebral ischemia (tGCI)-induced neuronal damage in hippocampal CA1 subregion in adult rats as demonstrated by our previous studies, little is understood about the role of Wnt/beta-catenin pathway in hypoxic postconditioning (HPC)-induced neuroprotection.	Oxygen	34-40	catenin beta 1	Rattus norvegicus	248-260
17628476-0	2007	Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a physiologically available oxygen carrier.	Oxygen	148-154	myoglobin	Homo sapiens	17-26
18787531-7	2009	Furthermore, inhibition of IFNgamma signaling and downregulation of IFNgammaR1 was also mediated by nonmetal-binding hypoxia mimetics and reduced oxygen tensions.	Oxygen	146-152	interferon gamma receptor 1	Homo sapiens	68-78
30633335-0	2019	Adenosine A2A receptor blocks the A 1 receptor inhibition of renal Na + transport and oxygen consumption.	Oxygen	86-92	adenosine A2a receptor	Homo sapiens	0-22
19178946-8	2009	DBH catalyses the hydroxylation of the important neurotransmitter dopamine into norepinephrine in the presence of both molecular oxygen and a reducing co-substrate.	Oxygen	129-135	dopamine beta-hydroxylase	Homo sapiens	0-3
17760653-3	2007	N-acetylcysteine ((NAC) has been shown to have oxygen scavenging abilities.	Oxygen	47-53	synuclein alpha	Homo sapiens	19-22
30633335-2	2019	Limited O2 availability leads to increased levels of adenosine, which regulates the kidney via activation of both A1 and A2A adenosine receptors (A1R and A2AR, respectively).	Oxygen	8-10	adenosine A2a receptor	Homo sapiens	154-158
17680181-10	2007	RESULTS: TcPO(2) increased significantly after spinal anesthesia only at T11, and was increased by oxygen administration at both T3 and T11.	Oxygen	99-105	CD2 molecule	Homo sapiens	136-139
19187779-2	2009	Using Caenorhabditis elegans we found extended oxygen deprivation resulted in activation of SBP-1, the worm homologue of SREBP1, a transcription factor important in maintaining lipid homeostasis.	Oxygen	47-53	sterol regulatory element binding transcription factor 1	Homo sapiens	121-127
17680181-11	2007	The increase of tcPO(2) after oxygen administration was larger at T3 than T11, without any differences in absolute values.	Oxygen	30-36	CD2 molecule	Homo sapiens	74-77
31167908-7	2019	Taken together, our findings suggest that hHB is a pleiotropic regulator of RIG-I/MDA5-mediated antiviral responses and further highlight the importance of the intercellular microenvironment, including the redox state, in regulating antiviral innate immune responses.IMPORTANCE Hemoglobin, the most important oxygen-carrying protein, is involved in the regulation of innate immune responses.	Oxygen	309-315	interferon induced with helicase C domain 1	Homo sapiens	82-86
17200776-5	2007	In the model of oxygen-induced retinopathy (OIR), Ang2 overexpression resulted in enhanced preretinal (+103%) and intraretinal neovascularization (+29%).	Oxygen	16-22	angiopoietin 2	Mus musculus	50-54
19267995-4	2009	Cytochrome c was found to enhance the catalytic rate of Drosophila melanogaster PPO under reduced oxygen conditions, and cytochrome c became reduced during PPO catalysis.	Oxygen	98-104	Protoporphyrinogen oxidase	Drosophila melanogaster	80-83
31257865-10	2019	We determined the P50 for oxygen to be 0.5 Torr for cytoglobin 1 and 4.4 Torr for cytoglobin 2 at 25  C. Thus, even at low oxygen tensions, the reduced cytoglobins may exist in a predominant oxygen-bound form.	Oxygen	26-32	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Danio rerio	18-21
19066318-6	2009	Insulin receptor-beta (IRbeta) and insulin receptor substrate-1 (IRS-1) were decreased in the adipose tissue of obese mice, and the alteration was observed in 3T3-L1 adipocytes after hypoxia (1% oxygen) treatment.	Oxygen	195-201	insulin receptor substrate 1	Mus musculus	65-70
19178466-0	2009	Novel controlling mechanism of the oxygen affinity in myoglobin with isomeric porphyrins.	Oxygen	35-41	myoglobin	Homo sapiens	54-63
18758939-5	2009	The biological activity of TAT-NEP1-40 was assessed by its effects against oxygen and glucose deprivation (OGD)-induced PC12 cell damages.	Oxygen	75-81	tyrosine aminotransferase	Rattus norvegicus	27-30
17349140-16	2007	(2) The expression of VEGF and Flk-1 on the 14(th) day in the oxygen group was significantly stronger than that of the control group (P &lt; 0.05).	Oxygen	62-68	vascular endothelial growth factor A	Rattus norvegicus	22-26
17349140-16	2007	(2) The expression of VEGF and Flk-1 on the 14(th) day in the oxygen group was significantly stronger than that of the control group (P &lt; 0.05).	Oxygen	62-68	kinase insert domain receptor	Rattus norvegicus	31-36
17349140-17	2007	In the oxygen group, VEGF and Flk-1 expression was the strongest in the retina on the 18(th) day, the result had significant difference as compared with the 14(th) and 25(th) day (P &lt; 0.05), and they were also stronger than that of the control group (P &lt; 0.05).	Oxygen	7-13	vascular endothelial growth factor A	Rattus norvegicus	21-25
17349140-17	2007	In the oxygen group, VEGF and Flk-1 expression was the strongest in the retina on the 18(th) day, the result had significant difference as compared with the 14(th) and 25(th) day (P &lt; 0.05), and they were also stronger than that of the control group (P &lt; 0.05).	Oxygen	7-13	kinase insert domain receptor	Rattus norvegicus	30-35
17102865-7	2006	The Cd2+ ion fits exactly inside the macrocyclic cavity exhibiting coordination number eight by coordination to all the donor atoms of the ligand, and additionally to two oxygen atoms from one nitrate anion and one oxygen atom from a water molecule.	Oxygen	171-177	CD2 molecule	Homo sapiens	4-7
17102865-7	2006	The Cd2+ ion fits exactly inside the macrocyclic cavity exhibiting coordination number eight by coordination to all the donor atoms of the ligand, and additionally to two oxygen atoms from one nitrate anion and one oxygen atom from a water molecule.	Oxygen	215-221	CD2 molecule	Homo sapiens	4-7
31257865-10	2019	We determined the P50 for oxygen to be 0.5 Torr for cytoglobin 1 and 4.4 Torr for cytoglobin 2 at 25  C. Thus, even at low oxygen tensions, the reduced cytoglobins may exist in a predominant oxygen-bound form.	Oxygen	123-129	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Danio rerio	18-21
17114981-1	2006	OBJECTIVE: Experimental and clinical studies have implicated that alpha1- and beta-adrenergic effects of epinephrine significantly increased the severity of postresuscitation myocardial dysfunction by increasing myocardial oxygen consumption during ventricular fibrillation.	Oxygen	223-229	adrenoceptor alpha 1D	Homo sapiens	66-72
19297239-4	2009	Within this class are first, enzymes that catalyze sulfur insertion, the prototype of which is biotin synthase; second, enzymes that catalyze P-methylation or C-methylation, such as P-methylase or Fom3; third, enzymes that catalyze oxygen insertion, such as the anaerobic magnesium protoporphyrin-IX oxidative cyclase (BchE); and fourth, enzymes that functionalize n-hexane or other alkanes as the first step in the metabolism of these inert compounds by certain bacteria.	Oxygen	232-238	butyrylcholinesterase	Homo sapiens	319-323
31257865-10	2019	We determined the P50 for oxygen to be 0.5 Torr for cytoglobin 1 and 4.4 Torr for cytoglobin 2 at 25  C. Thus, even at low oxygen tensions, the reduced cytoglobins may exist in a predominant oxygen-bound form.	Oxygen	123-129	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Danio rerio	18-21
31146911-0	2019	CXCL1 promotes the proliferation of neural stem cells by stimulating the generation of reactive oxygen species in APP/PS1 mice.	Oxygen	96-102	presenilin 1	Mus musculus	118-121
19181913-5	2009	Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment.	Oxygen	78-84	fatty acid binding protein 4	Homo sapiens	6-12
19181913-5	2009	Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment.	Oxygen	110-116	fatty acid binding protein 4	Homo sapiens	6-12
31273118-2	2019	We identify a thiol oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low oxygen affinity (high-K mO2) amino-terminal cysteine dioxygenase that transduces the oxygen-regulated stability of proteins by the N-degron pathway in human cells.	Oxygen	86-92	2-aminoethanethiol dioxygenase	Homo sapiens	97-100
19835089-3	2009	This yielded: k(Si + O2, 190-500 K) = 9.49 x 10(-11) + 1.80 x 10(-10) x exp(-T/115 K) cm3 molecule(-1) s(-1) (uncertainty &lt; or = +/- 15%), in good accord with recent high-level theoretical calculations but in marked disagreement with previous experimental work; k(Si + O3, 190-293 K) = (4.0 +/- 0.5) x 10(-10) cm3 molecule(-1) s(-1); k(Si + CO2, 293 K) &lt; or = 1.2 x 10(-14) cm3 molecule(-1) s(-1); and k(Si + H2O, 293 K) &lt; or = 2.6 x 10(-13) cm3 molecule(-1) s(-1).	Oxygen	21-23	complement C2	Homo sapiens	344-347
19026614-1	2009	The protein kinase-mediated actions of peptide growth factors such as IGF-1 and bFGF protect cultured neurons from being killed by the oxygen and glucose deprivations (OGD) that prevail in the "stroked brain".	Oxygen	135-141	insulin-like growth factor 1	Rattus norvegicus	70-75
31273118-2	2019	We identify a thiol oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low oxygen affinity (high-K mO2) amino-terminal cysteine dioxygenase that transduces the oxygen-regulated stability of proteins by the N-degron pathway in human cells.	Oxygen	112-118	2-aminoethanethiol dioxygenase	Homo sapiens	97-100
31281892-2	2019	In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1alpha expression was increased mainly by soluble factors released from obese adipocytes, leading to decreased incretin effects.	Oxygen	61-67	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
19089012-5	2009	The tetranuclear molecule has a cubane topology with the MnII and the deprotonated oxygen atoms from the eta1:eta3:eta1:micro3 ligands occupying alternate vertices of the cube.	Oxygen	83-89	secreted phosphoprotein 1	Homo sapiens	105-109
19089012-5	2009	The tetranuclear molecule has a cubane topology with the MnII and the deprotonated oxygen atoms from the eta1:eta3:eta1:micro3 ligands occupying alternate vertices of the cube.	Oxygen	83-89	secreted phosphoprotein 1	Homo sapiens	115-119
30508396-5	2019	Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including beta-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-gammaH2A.X (phosphorylated gamma-histone family member X).	Oxygen	25-27	H3 histone pseudogene 16	Homo sapiens	173-176
19129502-1	2009	The hypoxia-inducible factor (HIF) basic helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations.	Oxygen	272-278	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	58-108
19129502-1	2009	The hypoxia-inducible factor (HIF) basic helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations.	Oxygen	272-278	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	110-114
20008248-4	2009	Congenital causes include mutations of the erythropoietin receptor and defects of the oxygen-sensing pathway including VHL, PHD2 and HIF2A mutations.	Oxygen	86-92	endothelial PAS domain protein 1	Homo sapiens	133-138
19387116-2	2009	Increased expression of RAGE is observed in regions of the brain affected by Alzheimer"s disease (AD), and Abeta-RAGE interaction in vitro leads to cell stress with the generation of reactive oxygen species and activation of downstream signaling mechanisms including the MAP kinase pathway.	Oxygen	192-198	amyloid beta (A4) precursor protein	Mus musculus	107-112
31040157-4	2019	Using isogenic pairs with knockdown or overexpression of LKB1, KEAP1, and NRF2, we found that LKB1 loss results in increased energetic and redox stress marked by increased levels of intracellular reactive oxygen species and decreased levels of ATP, NADPH/NADP+ ratio, and glutathione.	Oxygen	205-211	serine/threonine kinase 11	Homo sapiens	94-98
18804541-1	2009	The aim of this study was to investigate the relationship between relative cerebral blood flow (delta CBF) and relative cerebral metabolic rate of oxygen (delta CMRO(2)) during continuous visual stimulation (21 min at 8 Hz) with fMRI biophysical models by simultaneously measuring of BOLD, CBF and CBV fMRI signals.	Oxygen	147-153	CCAAT enhancer binding protein zeta	Homo sapiens	102-105
18804541-5	2009	The time-dependent negative correlation between flow and metabolism demonstrated in this fMRI study is consistent with a previous PET observation and further supports the view that the increase in CBF is driven by factors other than oxygen demand and the energy demands will eventually require increased aerobic metabolism as stimulation continues.	Oxygen	233-239	CCAAT enhancer binding protein zeta	Homo sapiens	197-200
31497517-6	2019	Results: The patients in group A had higher oxygen saturation with a statistically significant difference in 15th to 75th minutes of the operation (P &lt; 0.001) and in post-anesthetic care unit (P = 0.004).	Oxygen	44-50	solute carrier family 35 member G1	Homo sapiens	169-173
30973706-9	2019	Both nitration and glycation enhanced the alpha-synuclein availability to be damaged by O2 -, although glycation made alpha-synuclein less reactive toward HO .	Oxygen	88-92	synuclein alpha	Homo sapiens	42-57
18973793-0	2008	Effect of erythropoietin on oxygen-induced brain injury in the newborn rat.	Oxygen	28-34	erythropoietin	Rattus norvegicus	10-24
19109240-0	2008	mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.	Oxygen	24-30	A kinase (PRKA) anchor protein 1	Mus musculus	0-5
31018430-6	2019	The observed enhanced stability is likely caused by the preferential attachment of the MS2 capsids onto MWNT surfaces, which is mediated by electrostatic attraction (between negatively charged oxygen-containing moieties on MWNTs and positively charged amino acid residues on MS2 surfaces) and/or by MS2 capsids with positive hydropathy index (indicating strong hydrophobicity).	Oxygen	193-199	MS2	Homo sapiens	87-90
18849495-9	2008	Interestingly, TLR3(-/-) mice exhibited less acute lung injury, activation of apoptotic cascades, and extracellular matrix deposition after 5 days of 80% oxygen compared with wild-type (TLR3(+/+)) mice under the same conditions.	Oxygen	154-160	toll-like receptor 3	Mus musculus	15-19
31184140-2	2019	Herein, we report rapid two-electron O2 reduction by a d0 ZrIV center with an appended redox-active Co-I site serving as an electron reservoir.	Oxygen	37-39	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	100-104
19021508-1	2008	The haem proteins TDO (tryptophan 2,3-dioxygenase) and IDO (indoleamine 2,3-dioxygenase) are specific and powerful oxidation catalysts that insert one molecule of dioxygen into L-tryptophan in the first and rate-limiting step in the kynurenine pathway.	Oxygen	38-46	indoleamine 2,3-dioxygenase 1	Homo sapiens	55-58
19021508-1	2008	The haem proteins TDO (tryptophan 2,3-dioxygenase) and IDO (indoleamine 2,3-dioxygenase) are specific and powerful oxidation catalysts that insert one molecule of dioxygen into L-tryptophan in the first and rate-limiting step in the kynurenine pathway.	Oxygen	38-46	indoleamine 2,3-dioxygenase 1	Homo sapiens	60-87
19021508-2	2008	Recent crystallographic and biochemical analyses of TDO and IDO have greatly aided our understanding of the mechanisms employed by these enzymes in the binding and activation of dioxygen and tryptophan.	Oxygen	178-186	indoleamine 2,3-dioxygenase 1	Homo sapiens	60-63
31091080-3	2019	Co-Black TNTs induce the activation of PMS by itself and stabilized oxygen vacancies that enhance the bonding with PMS and provide catalytic active sites for PMS activation.	Oxygen	68-74	troponin T1, slow skeletal type	Homo sapiens	9-13
31062993-0	2019	Effects of Oxygen-Containing Salts on the Detection of Organic Biomarkers on Mars and in Terrestrial Analog Soils.	Oxygen	11-17	methionyl-tRNA synthetase 1	Homo sapiens	77-81
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Oxygen	54-60	N-acetylglucosamine kinase	Homo sapiens	206-230
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Oxygen	54-60	N-acetylglucosamine kinase	Homo sapiens	232-236
31127273-5	2019	The mice overexpressing SIRT1 were more active, generated more heat, and had elevated oxygen consumption, possibly in compensation for the increased food intake.	Oxygen	86-92	sirtuin 1	Mus musculus	24-29
19011633-7	2008	Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53.	Oxygen	91-97	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	8-13
19011633-7	2008	Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53.	Oxygen	91-97	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	76-81
19011633-7	2008	Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53.	Oxygen	91-97	transformation related protein 53, pseudogene	Mus musculus	160-163
31124490-1	2019	Purpose: To evaluate the effect of cyanidin-3-glucoside (C3G) in oxygen-induced retinopathy (OIR) mouse model.	Oxygen	65-71	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	35-60
18728005-8	2008	Oxygen consumption studies support a specific defect in proton leak due to attenuated uncoupling protein 1 expression.	Oxygen	0-6	uncoupling protein 1	Homo sapiens	86-106
31239578-2	2019	Effective preparation for optimal oxygen delivery during CPB is dependent on a reliable estimation of total blood volume (TBV) to accurately predict dilutional hematocrit (Hct) and calculate indexed oxygen delivery (iDO2).	Oxygen	199-205	indoleamine 2,3-dioxygenase 2	Homo sapiens	216-220
18849322-6	2008	Thus, hypoxia signaling controls cardiac development through HIF1alpha-mediated transcriptional regulation of key components of myofibrillogenesis and the cardiac transcription factor network, thereby providing a mechanistic basis of how heart development, morphogenesis, and function is coupled to low oxygen tension during early embryogenesis.	Oxygen	303-309	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-70
18931236-2	2008	We hypothesized administration of oxygen (O2) using NPPV would more rapidly increase the end-tidal O2 concentration (ETO2) than preoxygenation using spontaneous ventilation (SV) in morbidly obese patients.	Oxygen	34-40	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	117-121
18931236-2	2008	We hypothesized administration of oxygen (O2) using NPPV would more rapidly increase the end-tidal O2 concentration (ETO2) than preoxygenation using spontaneous ventilation (SV) in morbidly obese patients.	Oxygen	42-44	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	117-121
18931236-2	2008	We hypothesized administration of oxygen (O2) using NPPV would more rapidly increase the end-tidal O2 concentration (ETO2) than preoxygenation using spontaneous ventilation (SV) in morbidly obese patients.	Oxygen	99-101	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	117-121
17049056-4	2006	Insulin secretion decreased on POD 3 in association with a significant increase of HIF-1alpha-related beta-cell death, which can be suppressed by short-term hyperbaric oxygen therapy.	Oxygen	168-174	hypoxia inducible factor 1, alpha subunit	Mus musculus	83-93
30927046-7	2019	Indeed, globular adiponectin enhances glucose uptake in Col6a1-/- myoblasts, modifies mitochondrial membrane potential, and restores oxygen consumption, turning closer to those of wild-type myoblasts.	Oxygen	133-139	adiponectin, C1Q and collagen domain containing	Mus musculus	17-28
16621884-14	2006	CONCLUSIONS: ScO2 and SsO2 may reflect the influence of haemodynamic variables and oxygen transport after the Norwood procedure.	Oxygen	83-89	synthesis of cytochrome C oxidase 2	Homo sapiens	13-17
16901899-7	2006	Here we show that Fe(III) alphaHb.AHSP forms from auto-oxidation of oxygenated alphaHb bound to AHSP and that this process is greatly accelerated at physiologic temperature and oxygen pressures.	Oxygen	68-74	alpha hemoglobin stabilizing protein	Homo sapiens	34-38
18793762-8	2008	It is proposed that mineral binding occurs via uncoordinated Gla oxygen ions binding to calcium in hydroxyapatite.	Oxygen	65-71	GLA	Bos taurus	61-64
18586877-11	2008	Breathing 60% oxygen reduced HIF-1alpha levels and HIF-1-regulated transcripts in lens epithelial cells from young and older lenses.	Oxygen	14-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	29-39
18586877-12	2008	Overexpression of oxygen-insensitive HIF-1alpha had no effect on lens size, but suppressed increased proliferation in response to oxygen.	Oxygen	18-24	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-47
18586877-12	2008	Overexpression of oxygen-insensitive HIF-1alpha had no effect on lens size, but suppressed increased proliferation in response to oxygen.	Oxygen	130-136	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-47
16901899-7	2006	Here we show that Fe(III) alphaHb.AHSP forms from auto-oxidation of oxygenated alphaHb bound to AHSP and that this process is greatly accelerated at physiologic temperature and oxygen pressures.	Oxygen	68-74	alpha hemoglobin stabilizing protein	Homo sapiens	96-100
31236115-8	2019	Our findings show that oxygen drives metabolite flux and specifies carbon fate in hPSC and, although the mechanism remains to be elucidated, oxygen was shown to alter methyltransferase and demethylase activity and the global epigenetic landscape.	Oxygen	23-29	methyl-CpG binding domain protein 2	Homo sapiens	189-200
16895900-1	2006	The heterodimeric flavocytochrome b558, comprised of the two integral membrane proteins p22phox and gp91phox, mediates the transfer of electrons from NADPH to molecular oxygen in the phagocyte NADPH oxidase to generate the superoxide precursor of microbicidal oxidants.	Oxygen	169-175	cytochrome b-245 alpha chain	Homo sapiens	88-95
18586877-14	2008	Increasing oxygen decreased levels of p27(KIP1) in the epithelial cells of older mice, which was prevented by expressing oxygen-insensitive forms of HIF-1alpha.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	149-159
31236115-8	2019	Our findings show that oxygen drives metabolite flux and specifies carbon fate in hPSC and, although the mechanism remains to be elucidated, oxygen was shown to alter methyltransferase and demethylase activity and the global epigenetic landscape.	Oxygen	141-147	methyl-CpG binding domain protein 2	Homo sapiens	189-200
19008939-6	2008	We used a new machine learning algorithm called MEDUSA to uncover detailed information about the oxygen regulatory network using genome-wide expression changes in response to perturbations in the levels of oxygen, heme, Hap1, and Co2+.	Oxygen	97-103	Hap1p	Saccharomyces cerevisiae S288C	220-224
31026140-2	2019	Here, in situ growth of mullite SmMn2O5 on nitrogen-doped reduced graphene oxide (SMO@NrGO) is achieved for highly efficient oxygen reduction reaction (ORR).	Oxygen	125-131	smoothened, frizzled class receptor	Homo sapiens	82-85
19008939-9	2008	This network includes both known oxygen and heme regulators, such as Hap1, Mga2, Hap4, and Upc2, as well as many new candidate regulators.	Oxygen	33-39	Hap1p	Saccharomyces cerevisiae S288C	69-73
18391853-11	2008	However, combined infusion of SOMA and NE significantly increased arterial lactate concentrations, oxygen consumption index, and oxygen extraction rate (P &lt; 0.05) and aggravated ileal mucosal injury.	Oxygen	99-105	somatostatin	Ovis aries	30-34
18391853-11	2008	However, combined infusion of SOMA and NE significantly increased arterial lactate concentrations, oxygen consumption index, and oxygen extraction rate (P &lt; 0.05) and aggravated ileal mucosal injury.	Oxygen	129-135	somatostatin	Ovis aries	30-34
17328145-10	2006	beta3-adrenergic oxygen-derived free radical production might be important in situations of enhanced beta3-adrenoceptor activation, as has been described in human heart failure.	Oxygen	17-23	adrenoceptor beta 3	Homo sapiens	101-119
17211489-3	2006	The basic alteration is a substitution of glutamic acid by valin in the sixth position of the beta globin chain, which causes polymerization at low oxygen tension thereby distorting the structure of erythrocytes and increasing blood viscosity, which, in turn, generates obstructions of the capillary arterial blood flow to different areas of the body thus causing microinfarctions.	Oxygen	148-154	hemoglobin subunit beta	Homo sapiens	94-111
31083568-3	2019	Various underlying pathways, such as beta-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors.	Oxygen	135-141	catenin beta 1	Homo sapiens	37-49
16987417-2	2006	We hypothesized that either linear or nonlinear mathematical manipulation of the partial pressure of oxygen in breath at end expiration (EtO2) would accurately predict ScVO2.	Oxygen	101-107	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	137-141
21158143-6	2008	With electricmicroscope, it was founded that in the control group and 2% sevoflurane group, the pyramidal neurons in CA1 regions deprived with glucose and oxygen and exposured by Glu were damaged.	Oxygen	155-161	carbonic anhydrase 1	Rattus norvegicus	117-120
31015364-6	2019	EPAS1 is a type of hypoxia-inducible factors, which are collected as a group of transcription factors involved in body response to oxygen level.	Oxygen	131-137	endothelial PAS domain protein 1	Homo sapiens	0-5
31021042-4	2019	The resultant ZIF-Co3 O4 /NCF is interweaved into a self-supported film and can be used as a bi-functional catalyst for catalysing oxygen reduction in both aqueous and non-aqueous electrolytes.	Oxygen	131-137	neutrophil cytosolic factor 4	Homo sapiens	26-29
18675363-5	2008	Significant blood oxygen level dependent (BOLD) signal increases were observed in the left primary sensorimotor cortex (SM1) in the paracentral lobule and in secondary motor areas for all tasks.	Oxygen	18-24	SM1	Homo sapiens	120-123
18729334-2	2008	Surface reactions of O2, CHCl3, and CCl4 on the Ag particles and bulk Ag(111) surfaces were studied by X-ray photoelectron spectroscopy (XPS), and it has been shown that size dependence of O2 and CHCl3 reactions on Ag differs from that of CCl4.	Oxygen	21-23	C-C motif chemokine ligand 4	Homo sapiens	239-243
18729334-2	2008	Surface reactions of O2, CHCl3, and CCl4 on the Ag particles and bulk Ag(111) surfaces were studied by X-ray photoelectron spectroscopy (XPS), and it has been shown that size dependence of O2 and CHCl3 reactions on Ag differs from that of CCl4.	Oxygen	189-191	C-C motif chemokine ligand 4	Homo sapiens	36-40
16965630-8	2006	CONCLUSION: These results are consistent with the view that oxygen cost of dynamic and isometric actions is determined by different circumstances of mechanical interaction between actin and myosin in the sarcomere, and that muscle recruitment has only a minor role.	Oxygen	60-66	myosin heavy chain 14	Homo sapiens	190-196
31021042-5	2019	Electrochemical tests demonstrate that ZIF-Co3 O4 /NCF displays a high catalytic activity for oxygen reduction with a half-wave potential (E1/2 ) of 0.813 V (vs. RHE) and an almost favourable four-electron reduction pathway in alkaline medium.	Oxygen	94-100	neutrophil cytosolic factor 4	Homo sapiens	51-54
16847054-3	2006	We further demonstrated that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor (HIF)-1alpha up-regulation in EGF-treated cancer cells.	Oxygen	83-89	epidermal growth factor	Homo sapiens	157-160
18787098-8	2008	These studies show that SOD3 is essential for survival in the presence of ambient oxygen and that acute loss of this enzyme can lead to severe lung damage.	Oxygen	82-88	superoxide dismutase 3, extracellular	Mus musculus	24-28
30872402-1	2019	Myoglobin is a monomeric heme protein expressed ubiquitously in skeletal and cardiac muscle and is traditionally considered to function as an oxygen reservoir for mitochondria during hypoxia.	Oxygen	142-148	myoglobin	Homo sapiens	0-9
18692496-3	2008	We observed that the proliferative capacity of the rat cell lines NRK and INS-1 was inhibited when cultured under 3% oxygen as compared to 20% oxygen.	Oxygen	117-123	insulin 1	Rattus norvegicus	74-79
16835250-6	2006	Reporter assays reveal that the CXCL12 promoter activity is enhanced in LNT-229 cells at 24 h after irradiation at 8 Gy or after exposure to 1% oxygen for 12 h. The irradiation- and hypoxia-induced release of CXCL12 depends on hypoxia inducible factor-1 alpha (HIF-1alpha), but not on p53.	Oxygen	144-150	hypoxia inducible factor 1, alpha subunit	Mus musculus	227-259
16835250-6	2006	Reporter assays reveal that the CXCL12 promoter activity is enhanced in LNT-229 cells at 24 h after irradiation at 8 Gy or after exposure to 1% oxygen for 12 h. The irradiation- and hypoxia-induced release of CXCL12 depends on hypoxia inducible factor-1 alpha (HIF-1alpha), but not on p53.	Oxygen	144-150	hypoxia inducible factor 1, alpha subunit	Mus musculus	261-271
16835250-6	2006	Reporter assays reveal that the CXCL12 promoter activity is enhanced in LNT-229 cells at 24 h after irradiation at 8 Gy or after exposure to 1% oxygen for 12 h. The irradiation- and hypoxia-induced release of CXCL12 depends on hypoxia inducible factor-1 alpha (HIF-1alpha), but not on p53.	Oxygen	144-150	transformation related protein 53, pseudogene	Mus musculus	285-288
18586770-3	2008	In the inactivation, the Co-C bond of adenosylcobalamin underwent irreversible cleavage forming unidentified radicals and cob(II)alamin that resisted oxidation even in the presence of oxygen.	Oxygen	184-190	metabolism of cobalamin associated B	Homo sapiens	46-49
30844336-1	2019	Near infrared spectroscopy (NIRS) is a powerful noninvasive tool with which to study the matching of oxygen delivery to oxygen utilization and the number of new publications utilizing this technique has increased exponentially in the last 20 yr. By measuring the state of oxygenation of the primary heme compounds in skeletal muscle (hemoglobin and myoglobin), greater understanding of the underlying control mechanisms that couple perfusive and diffusive oxygen delivery to oxidative metabolism can be gained from the laboratory to the athletic field to the intensive care unit or emergency room.	Oxygen	101-107	myoglobin	Homo sapiens	349-358
18846340-4	2008	The results showed that in hypoxia group, the VEGF gene bands were seen and with the decrease of oxygen concentrations and prolongation of hypoxia time, the expression of VEGF mRNA was obviously increased.	Oxygen	97-103	vascular endothelial growth factor A	Rattus norvegicus	171-175
16765421-5	2006	The earliest MSA archaeological phase, M3, from where fragments of ochre were found as well as human teeth, is dated to 98.9+/-4.5 ka, coinciding with the sea-level high of oxygen isotope substage 5c.	Oxygen	173-179	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	155-158
16741907-5	2006	The NMR studies were in agreement with preferential complexation of Al(OTf)(3) to the oxygen atom of the unsaturated alcohol, but did not exclude complexation to the double bond of the alcohol.	Oxygen	86-92	POU class 5 homeobox 1	Homo sapiens	68-77
16741907-6	2006	Theoretical calculations indicated strong acidification of the hydroxyl proton when Al(OTf)(3) was complexed to the alcohol oxygen atom.	Oxygen	124-130	POU class 5 homeobox 1	Homo sapiens	84-93
30862527-0	2019	Phase-controlled intermittent intratracheal insufflation of oxygen during chest compression-active decompression mCPR improves coronary perfusion pressure over continuous insufflation.	Oxygen	60-66	cytochrome p450 oxidoreductase	Mus musculus	113-117
16790428-3	2006	Paradoxically, the expression of two family members (PHD2 and PHD3) is induced in hypoxic cell culture despite the reduced availability of the oxygen co-substrate, and it has been suggested that they become functionally relevant following re-oxygenation to rapidly terminate the HIF response.	Oxygen	143-149	egl-9 family hypoxia-inducible factor 1	Mus musculus	53-57
16790428-3	2006	Paradoxically, the expression of two family members (PHD2 and PHD3) is induced in hypoxic cell culture despite the reduced availability of the oxygen co-substrate, and it has been suggested that they become functionally relevant following re-oxygenation to rapidly terminate the HIF response.	Oxygen	143-149	egl-9 family hypoxia-inducible factor 3	Mus musculus	62-66
19040188-2	2008	We examined if the degree of CNS penetration by cART, as estimated by the CNS penetration effectiveness (CPE) score, affects brain activity as measured by the amplitude of the blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) response.	Oxygen	182-188	carboxypeptidase E	Homo sapiens	105-108
19099877-7	2008	Under 100% O2 exposure for 72 h, it caused 7-fold decreased Gpx1 expression in Prdx6-/- mouse lung with no remarkable decrease of Prdx6 expression in Gpx1-/- mice.	Oxygen	11-13	glutathione peroxidase 1	Mus musculus	60-64
31034531-2	2019	Originally identified as oxygen sensor in the cellular response to hypoxia, where FIH acts as a repressor of the hypoxia inducible transcription factor alpha (HIF-alpha) proteins through asparaginyl hydroxylation, FIH also hydroxylates many proteins that contain ankyrin repeat domains (ARDs).	Oxygen	25-31	hypoxia-inducible factor 1-alpha inhibitor	Tribolium castaneum	159-162
18644387-1	2008	Hyperbaric oxygen preconditioning (HBO-PC) increases the level of HIF-1alpha (hypoxia inducible factor-1alpha) and its target gene VEGF (vascular endothelial growth factor) which is involved in angiogenesis.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	131-135
18644387-1	2008	Hyperbaric oxygen preconditioning (HBO-PC) increases the level of HIF-1alpha (hypoxia inducible factor-1alpha) and its target gene VEGF (vascular endothelial growth factor) which is involved in angiogenesis.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	137-171
18598060-12	2008	Their nucleophilic character at C-2 permits reactions with oxygen, nitrogen, and sulfur electrophiles that under high substrate stereocontrol generally lead to three-membered rings; ring opening under acid catalysis furnishes the corresponding glycosides, whichdepending on the electrophile Xare also employed for 2-deoxyglycoside synthesis.	Oxygen	59-65	complement C2	Homo sapiens	32-35
16547490-0	2006	Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation.	Oxygen	74-80	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	31-35
16547490-4	2006	In low oxygen tension conditions, the HIF1alpha/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity.	Oxygen	7-13	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	52-56
16831408-12	2006	Furthermore, PDGF-B retention is also necessary for the development of an adequate capillary density, and thereby for a normal oxygen delivery to skeletal muscle.	Oxygen	127-133	platelet derived growth factor, B polypeptide	Mus musculus	13-19
18705802-6	2008	These findings suggest that HIF-1alpha becomes stabilized independently of the concentration of oxygen, and largely contributes to the development and resorption of Meckel"s cartilage, probably through shifting the predominant metabolic mode from aerobic to anaerobic glycolysis.	Oxygen	96-102	hypoxia inducible factor 1, alpha subunit	Mus musculus	28-38
31034531-8	2019	Overall, these data show that while oxygen-dependent HIF-alpha hydroxylation by FIH is highly conserved in many species, HIF-independent roles for FIH have evolved in others.	Oxygen	36-42	hypoxia-inducible factor 1-alpha inhibitor	Tribolium castaneum	53-56
16890541-2	2006	The Target of Rapamycin (TOR) responds to changes in growth factors, amino acids, oxygen tension, and energy status; however, it is unclear how TOR contributes to physiological homeostasis and disease conditions.	Oxygen	82-88	Target of rapamycin	Drosophila melanogaster	4-23
16890541-2	2006	The Target of Rapamycin (TOR) responds to changes in growth factors, amino acids, oxygen tension, and energy status; however, it is unclear how TOR contributes to physiological homeostasis and disease conditions.	Oxygen	82-88	Target of rapamycin	Drosophila melanogaster	25-28
31183065-4	2019	We investigated the catalytic performance of Au x Ru1-x NPs for the oxygen evolution reaction, for which Ru is well known to be one of the best monometallic catalysts, and we found that even alloying with a small amount of Au could significantly enhance the catalytic performance.	Oxygen	68-74	Scm like with four mbt domains 1	Homo sapiens	50-53
18445132-6	2008	AtCYP38 mutant plants also showed decreased accumulation of PSII, which was shown not to originate from impaired D1 synthesis or assembly of PSII monomers, dimers and supercomplexes as such but rather from the incorrect fine-tuning of the oxygen-evolving side of PSII.	Oxygen	239-245	cyclophilin 38	Arabidopsis thaliana	0-7
17723508-1	2006	An optical bio-sniffer for methyl mercaptan (MM) one of major odorous chemicals in halitosis (bad breath) was constructed by immobilizing monoamine oxidase type A (MAO-A) onto a tip of a fiber optic oxygen sensor (od: 1.59 mm) with an oxygen sensitive ruthenium organic complex (excitation: 470 nm, fluorescent: 600 nm).	Oxygen	199-205	monoamine oxidase A	Homo sapiens	164-169
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	70-76	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	20-57
17723508-1	2006	An optical bio-sniffer for methyl mercaptan (MM) one of major odorous chemicals in halitosis (bad breath) was constructed by immobilizing monoamine oxidase type A (MAO-A) onto a tip of a fiber optic oxygen sensor (od: 1.59 mm) with an oxygen sensitive ruthenium organic complex (excitation: 470 nm, fluorescent: 600 nm).	Oxygen	235-241	monoamine oxidase A	Homo sapiens	164-169
17723508-5	2006	The optical bio-sniffer was applied to detect the oxygen consumption induced by MAO-A enzymatic reaction (and AsA chemical reduction) with gaseous MM application.	Oxygen	50-56	monoamine oxidase A	Homo sapiens	80-85
18825932-6	2008	We found that CNB D allele was associated with increased left ventricular mass index and low values of physical performance (when maximal power production capacity and maximal oxygen consumption were measured).	Oxygen	176-182	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	14-17
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	70-76	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	59-64
16483558-8	2006	The oxygen-sensitive signaling pathways involved have been characterized and point towards a central role of p21, TGFbeta and p38MAPK.	Oxygen	4-10	H3 histone pseudogene 16	Homo sapiens	109-112
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	115-121	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	20-57
18641800-8	2008	CONCLUSION: Liver preconditioning with hyperbaric oxygen therapy aggravated liver ischemia/reperfusion injury in rats as demonstrated by plasma ALT and liver myeloperoxidase activity.	Oxygen	50-56	myeloperoxidase	Rattus norvegicus	158-173
30996134-8	2019	We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.	Oxygen	115-121	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	59-64
31380163-0	2019	Iron-Salen Complex and Co2+ Ion-Derived Cobalt-Iron Hydroxide/Carbon Nanohybrid as an Efficient Oxygen Evolution Electrocatalyst.	Oxygen	96-102	complement C2	Homo sapiens	23-26
18302236-3	2008	Cells expanded at 1.5% O2 were characterized by low citrate synthase (aerobic energy metabolism)--and high LDH (anaerobic energy metabolism-activities,suggesting an anaerobic energy metabolism.	Oxygen	23-25	citrate synthase	Bos taurus	52-68
16814750-7	2006	To mimic the ischemia-reperfusion injury in experimental animals, we employed hippocampal slice cultures that were first treated with oxygen and glucose deprivation (OGD) and then with oxygen-glucose resupply, finding that fibronectin significantly increased the neurite outgrowth of OGD hippocampal slices, upregulated the expression of Bcl-2 protein, and ameliorated the ultrastructure damage of OGD hippocampal slices.	Oxygen	134-140	fibronectin 1	Rattus norvegicus	223-234
31380163-2	2019	Here, CoFe hydroxide/carbon nanohybrid is reported as an efficient oxygen evolution electrocatalyst derived from the in situ formed molecular Fe-salen complexes and Co2+ ions at a low temperature of 160  C. It has been evidenced that Fe-salen as a molecular precursor facilitates the confined-growth of metal hydroxides, while Co2+ plays a critical role in catalyzing the transformation of organic ligand into nanocarbons and constitutes an essential component for CoFe hydroxide.	Oxygen	67-73	complement C2	Homo sapiens	165-168
18535207-2	2008	Usually, bridging oxygen (Obr) vacancies are assumed to cause the Ti3d defect state in the band gap of rutile TiO2(110).	Oxygen	18-24	leptin receptor	Homo sapiens	26-29
18356561-6	2008	As compared with noncarriers, BMPR2 mutation carriers were younger at diagnosis of PAH (36.5 +/- 14.5 vs. 46.0 +/- 16.1 yr, P < 0.0001), had higher mean pulmonary artery pressure (64 +/- 13 vs. 56 +/- 13 mm Hg, P < 0.0001), lower cardiac index (2.13 +/- 0.68 vs. 2.50 +/- 0.73 L/min/m(2), P = 0.0005), higher pulmonary vascular resistance (17.4 +/- 6.1 vs. 12.7 +/- 6.6 mm Hg/L/min/m(2), P < 0.0001), lower mixed venous oxygen saturation (59 +/- 9% vs. 63 +/- 9%, P = 0.02), shorter time to death or lung transplantation (P = 0.044), and younger age at death (P = 0.002), but similar overall survival (P = 0.51).	Oxygen	420-426	bone morphogenetic protein receptor type 2	Homo sapiens	30-35
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	131-137	vascular endothelial growth factor A	Rattus norvegicus	190-194
17100325-1	2006	Composition of culture medium for cultivation of chlorate-reducing strain A. thermotoleranticus C-1 has been optimized with the purpose to decontaminate sewage from production of fuel mixtures, match production sewage, including toxical oxygen-containing anions-chlorates, chromates in particular.	Oxygen	237-243	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	96-99
31380163-2	2019	Here, CoFe hydroxide/carbon nanohybrid is reported as an efficient oxygen evolution electrocatalyst derived from the in situ formed molecular Fe-salen complexes and Co2+ ions at a low temperature of 160  C. It has been evidenced that Fe-salen as a molecular precursor facilitates the confined-growth of metal hydroxides, while Co2+ plays a critical role in catalyzing the transformation of organic ligand into nanocarbons and constitutes an essential component for CoFe hydroxide.	Oxygen	67-73	complement C2	Homo sapiens	327-330
16830212-3	2006	Oxygen/glucose deprivation (OGD) of neuron/astrocyte co-cultures resulted in the massive death of neurons, and the cell death was significantly reduced by treatment with either AP5 or DHK.	Oxygen	0-6	adaptor related protein complex 5 subunit beta 1	Homo sapiens	177-180
30680481-6	2019	Overexpression of ALR reduced the level of reactive oxygen species and the rate of apoptosis in H2O2-treated HK-2 cells.	Oxygen	52-58	growth factor, augmenter of liver regeneration	Homo sapiens	18-21
16462764-3	2006	shRNA-mediated downregulation of c-Met in F10 cells led to a parallel decrease in the generation of oxygen species and in metastatic capacity, suggesting that oxidants may mediate the pro-metastatic activity of the HGF receptor.	Oxygen	100-106	met proto-oncogene	Mus musculus	33-38
16462764-3	2006	shRNA-mediated downregulation of c-Met in F10 cells led to a parallel decrease in the generation of oxygen species and in metastatic capacity, suggesting that oxidants may mediate the pro-metastatic activity of the HGF receptor.	Oxygen	100-106	met proto-oncogene	Mus musculus	215-227
30519802-0	2019	Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C.	Oxygen	54-60	cystatin C	Rattus norvegicus	92-102
16721367-9	2006	This result suggests a role for GCP-2 in promoting tumour progression in vivo under unfavourable conditions such as oxygen deprivation.	Oxygen	116-122	C-X-C motif chemokine ligand 6	Homo sapiens	32-37
30519802-1	2019	We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear.	Oxygen	118-124	cystatin C	Rattus norvegicus	33-43
30519802-1	2019	We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear.	Oxygen	118-124	cystatin C	Rattus norvegicus	45-49
16728594-5	2006	SCO2 is critical for regulating the cytochrome c oxidase (COX) complex, the major site of oxygen utilization in the eukaryotic cell.	Oxygen	90-96	synthesis of cytochrome C oxidase 2	Homo sapiens	0-4
30519802-1	2019	We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear.	Oxygen	118-124	cystatin C	Rattus norvegicus	190-194
30546089-8	2019	We conclude that oxygen pressure in the tumor microenvironment orchestrates an anti- and pro-tumoral gammadelta T-cell equilibrium by altering TEX content, which subsequently regulates MDSC function in a miR-21/PTEN/PD-L1-axis-dependent manner.	Oxygen	17-23	microRNA 21	Homo sapiens	204-210
16709326-0	2006	Reference values for oxygen saturation by pulse oximetry in healthy children at sea level in Chennai.	Oxygen	21-27	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	80-83
16709326-2	2006	AIM: To determine the reference values for oxygen saturation by pulse oximetry in healthy children living at sea level in Chennai and aged between 1 mth and 5 yrs.	Oxygen	43-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
30546089-8	2019	We conclude that oxygen pressure in the tumor microenvironment orchestrates an anti- and pro-tumoral gammadelta T-cell equilibrium by altering TEX content, which subsequently regulates MDSC function in a miR-21/PTEN/PD-L1-axis-dependent manner.	Oxygen	17-23	phosphatase and tensin homolog	Homo sapiens	211-215
30482269-4	2019	We hypothesised that the presence of haemoglobin invivo creates a low oxygen environment to induce oxygen-regulated gene expression, supported by high expression of Slc2a1 and Ndrg1 in invivo relative to invitro embryos.	Oxygen	99-105	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	165-171
16696848-3	2006	Here, we describe experiments using an enzyme-based adenosine sensor to show that adenosine potently (IC50 approximately 1 microm) inhibits excitatory synaptic transmission in area CA1 during oxygen/glucose deprivation ("ischaemia"), and that the prolonged post-ischaemic presence of extracellular adenosine sustains the depression of the field excitatory postsynaptic potential (fEPSP).	Oxygen	192-198	carbonic anhydrase 1	Rattus norvegicus	181-184
16581864-1	2006	The tight relation between arterial oxygen content and maximum oxygen uptake (Vv(o2max)within a given person at sea level is diminished with altitude acclimatization.	Oxygen	36-42	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
16581864-1	2006	The tight relation between arterial oxygen content and maximum oxygen uptake (Vv(o2max)within a given person at sea level is diminished with altitude acclimatization.	Oxygen	63-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
30942155-3	2019	However, the expression of VEGF is inhibited by decreases in oxygen content, which is different from what obtains in Sprague Dawley (SD)rats.	Oxygen	61-67	vascular endothelial growth factor A	Rattus norvegicus	27-31
16600997-12	2006	Our findings indicate that Lck is required for the acute response to hypoxia of human T lymphocytes as it is necessary to confer O(2) sensitivity on Kv 1.3 channels.	Oxygen	129-133	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
30886181-0	2019	Dissolved organic carbon contribution to oxygen respiration in the central Red Sea.	Oxygen	41-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	79-82
16545962-10	2006	In the active structures, S20 interacts with the gamma-P oxygen in Rab11b-GppNHp but does not in Rab11a-GppNHp and the Q70 side chain is found in different positions.	Oxygen	57-63	ribosomal protein S20	Homo sapiens	26-29
16681389-7	2006	In further support of this hypothesis, recombinant HDAC8 purified from E. coli contains 8-fold more iron than zinc before dialysis, and the HDAC8 activity in cell lysates is oxygen-sensitive.	Oxygen	174-180	histone deacetylase 8	Homo sapiens	51-56
16681389-7	2006	In further support of this hypothesis, recombinant HDAC8 purified from E. coli contains 8-fold more iron than zinc before dialysis, and the HDAC8 activity in cell lysates is oxygen-sensitive.	Oxygen	174-180	histone deacetylase 8	Homo sapiens	140-145
16676986-3	2006	In the ferrous state, the oxygen affinity of the new myoglobin was decreased to 1/410 of the native protein.	Oxygen	26-32	myoglobin	Homo sapiens	53-62
30309268-9	2019	MEASUREMENTS AND MAIN RESULTS: Acute intranasal, but not intraperitoneal, leptin decreased the number of oxygen desaturation events in REM sleep, and increased ventilation in non-REM and REM sleep, independently of metabolic effects.	Oxygen	105-111	leptin	Mus musculus	74-80
16624658-5	2006	Levels of E-selectin and intercellular cell adhesion molecule-1 were significantly correlated to total oxygen desaturation.	Oxygen	103-109	selectin E	Homo sapiens	10-20
30984338-4	2019	We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2alpha-ATF4, IRE 1-XBP1, and ATF 6.	Oxygen	17-19	X-box binding protein 1	Rattus norvegicus	138-142
17181051-1	2006	We studied the role of Thy-1,2+ cells in the regulation of hemopoiesis during oxygen deficiency of different genesis.	Oxygen	78-84	Thy-1 cell surface antigen	Homo sapiens	23-30
16623832-3	2006	Indeed, hypoxia-inducible factor-1 (HIF-1), one of the main transcriptional factors regulated by oxygen level, increases the expression of several beneficial genes such as erythropoietin, glucose transporter-1 and vascular endothelial growth factor.	Oxygen	97-103	erythropoietin	Rattus norvegicus	172-186
30984338-4	2019	We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2alpha-ATF4, IRE 1-XBP1, and ATF 6.	Oxygen	17-19	activating transcription factor 6	Rattus norvegicus	148-153
30657727-8	2019	The cellular oxygen consumption rate (OCR) was increased in both pre-miR-21-5p- and anti-miR-21-5p-transfected cells.	Oxygen	13-19	microRNA 215	Rattus norvegicus	89-98
16556309-7	2006	The LPS O-chain protects the bacteria from cellular cationic peptides, oxygen metabolites and complement-mediated lysis and it is a key molecule for Brucella survival and replication in the host.	Oxygen	71-77	interferon regulatory factor 6	Homo sapiens	4-7
30264370-5	2019	Exosomes from obese human plasma mediated cardiomyocyte mitochondrial inactivity, but pre-treatment with miR-29a sponge attenuated the exosomal miR-29a-induced reduction of ATP production (p < 0.001), basal oxygen consumption (p < 0.01) and mitochondrial complex I activity (p < 0.01).	Oxygen	207-213	microRNA 29a	Homo sapiens	105-112
16553631-3	2006	To approach this issue the present study examined BDNF secretion from brain endothelial cells in response to reduced oxygen availability (hypoxia), using the mouse brain microvascular endothelial cell line, bEnd.3.	Oxygen	117-123	brain derived neurotrophic factor	Mus musculus	50-54
16507861-0	2006	Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude.	Oxygen	14-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	73-76
30264370-5	2019	Exosomes from obese human plasma mediated cardiomyocyte mitochondrial inactivity, but pre-treatment with miR-29a sponge attenuated the exosomal miR-29a-induced reduction of ATP production (p < 0.001), basal oxygen consumption (p < 0.01) and mitochondrial complex I activity (p < 0.01).	Oxygen	207-213	microRNA 29a	Homo sapiens	144-151
16507861-1	2006	The aim of this study was to determine the prevalence of oxygen desaturation in adults aged&gt;or=40 yrs as altitude above sea level increases.	Oxygen	57-63	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	123-126
30710328-2	2019	BCS, ACS, and GOS were synthesized mainly via the interaction between hydrolyzed 3-MPTS and surface oxygen-containing functional groups (e.g., -OH, O-C=O, and C=O) and pi-pi interaction.	Oxygen	100-106	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	5-8
16429430-10	2006	Peak oxygen consumption was significantly improved at the Dead Sea compared with sea level (1.68 +/- 0.73 vs. 1.57 +/- 0.74 l/min, respectively, P = 0.05), along with an improvement in the ventilatory equivalent for oxygen (41.2 +/- 6.3 vs. 46.1 +/- 7.1, respectively, P &lt; 0.05).	Oxygen	5-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
16429430-10	2006	Peak oxygen consumption was significantly improved at the Dead Sea compared with sea level (1.68 +/- 0.73 vs. 1.57 +/- 0.74 l/min, respectively, P = 0.05), along with an improvement in the ventilatory equivalent for oxygen (41.2 +/- 6.3 vs. 46.1 +/- 7.1, respectively, P &lt; 0.05).	Oxygen	216-222	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
30475644-0	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	toll like receptor 4	Homo sapiens	8-12
16429430-11	2006	During submaximal exercise, blood oxygen saturation improved at the Dead Sea compared with sea level at all exercise intensities (P &lt; 0.05).	Oxygen	34-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	73-76
30578297-5	2019	Suppression of PGC-1alpha expression by shRNA in the PGC-1alpha-positive U343MG glioblastoma line suppressed mitochondrial gene expression, reduced mitochondrial membrane potential, and diminished oxygen as well as glucose consumption, and lactate production.	Oxygen	197-203	PPARG coactivator 1 alpha	Sus scrofa	15-25
16407398-0	2006	Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.	Oxygen	34-40	heparin binding EGF like growth factor	Homo sapiens	104-142
16407398-3	2006	Using a well-characterized human first trimester cytotrophoblast cell line, we found that a 4-hour exposure to 2% O(2) upregulates HBEGF synthesis and secretion independently of an increase in its mRNA.	Oxygen	114-118	heparin binding EGF like growth factor	Homo sapiens	131-136
30578297-5	2019	Suppression of PGC-1alpha expression by shRNA in the PGC-1alpha-positive U343MG glioblastoma line suppressed mitochondrial gene expression, reduced mitochondrial membrane potential, and diminished oxygen as well as glucose consumption, and lactate production.	Oxygen	197-203	PPARG coactivator 1 alpha	Sus scrofa	53-63
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	heparin binding EGF like growth factor	Homo sapiens	46-51
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	heparin binding EGF like growth factor	Homo sapiens	84-89
30887719-0	2019	HBx inhibits HMGB1 expression and active oxygen production in LO2 cells through the NF-kappaB signaling pathway.	Oxygen	41-47	X protein	Hepatitis B virus	0-3
16407398-7	2006	The restoration of trophoblast survival by the addition of soluble HBEGF in cultures exposed to low O(2) and metalloproteinase inhibitor suggests that the effects of HBEGF are mediated by autocrine/paracrine, rather than juxtacrine, signaling.	Oxygen	100-104	heparin binding EGF like growth factor	Homo sapiens	67-72
16407398-8	2006	Our results provide evidence that a post-transcriptional mechanism induced in trophoblasts by low O(2) rapidly amplifies HBEGF signaling to inhibit apoptosis.	Oxygen	98-102	heparin binding EGF like growth factor	Homo sapiens	121-126
16040186-9	2006	Among the proteins that were more abundant under oxygen exposure, several thiol-specific peroxidases (thiol-peroxidase, BCP-like protein, and putative glutaredoxin) were identified.	Oxygen	49-55	DVU0883	Desulfovibrio vulgaris str. Hildenborough	151-163
16288482-3	2006	During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates.	Oxygen	93-99	butyrylcholinesterase	Homo sapiens	7-11
16288482-3	2006	During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates.	Oxygen	93-99	butyrylcholinesterase	Homo sapiens	154-158
18463234-1	2008	Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line".	Oxygen	64-66	endothelial PAS domain protein 1	Homo sapiens	23-33
18463234-1	2008	Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line".	Oxygen	85-87	endothelial PAS domain protein 1	Homo sapiens	23-33
30347116-3	2019	A kind of hydrophobic polymer (i.e., PFPtTFPP) as an imaging probe for hypoxia with fluorene as an energy donor and an oxygen-sensitive PtII porphyrin as an energy acceptor was developed.	Oxygen	119-125	perforin 1	Homo sapiens	37-45
18283283-7	2008	CONCLUSION: The stimulatory effects of leptin on oxygen consumption, BAT UCP1 and D2 expression require functional beta-adrenoceptors, but its inhibitory effect on food intake and its stimulatory effect on fat utilization is independent of the beta-adrenoceptor signalling.	Oxygen	49-55	leptin	Mus musculus	39-45
16123391-0	2006	Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells.	Oxygen	9-11	CD34 antigen	Mus musculus	62-66
16123391-2	2006	We compared the effects of 20%, 3%, and 0.1% O2 concentrations on cord blood CD34+ cell survival, cycle, and functionality in serum-free cultures for 72 hours with or without interleukin-3 (IL-3).	Oxygen	45-47	CD34 antigen	Mus musculus	77-81
16123391-8	2006	In conclusion, a low O2 concentration, close to those found in bone marrow stem cell niches, induces the G0 return of CD34+ cells without impairing their functional capacity.	Oxygen	21-23	CD34 antigen	Mus musculus	118-122
30788743-1	2019	We performed a complex study of the dependence of immediate reaction of catalytic subunits in mitochondrial enzymes (NDUFV2, SDHA, Cyt b, COX1, and ATP5A) in rat cerebral cortex (the most hypoxia-sensitive tissue) on the severity and duration of hypoxia in vivo and the role of individual resistance of rats to oxygen deficiency in this process.	Oxygen	311-317	NADH:ubiquinone oxidoreductase core subunit V2	Rattus norvegicus	117-123
16532746-7	2006	The oxygen/nitrate return sludge model block predicts a 10% improvement of N removal performance under dynamic conditions, and might be the better modelling option for ASM1 plants: it is computationally more efficient and it will not overrate the importance of decay processes in the settler.	Oxygen	4-10	H19 imprinted maternally expressed transcript	Homo sapiens	168-172
18459144-5	2008	On the basis of this observation, the present study was performed to verify the involvement of HIF-1, and in particular the effect of chemical and environmental induction of HIF-1alpha (the oxygen sensitive isoform) accumulation in 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR, the key and rate limiting enzyme of cholesterol biosynthetic pathway) regulation.	Oxygen	190-196	hypoxia inducible factor 1, alpha subunit	Mus musculus	174-184
30391712-6	2019	Dissolved oxygen (DO) would compete with Cr(VI) for Fe(II) and S(-II) and inhibit the process of Cr(VI) reduction at pH 5.6.	Oxygen	10-16	transcription elongation factor A1	Homo sapiens	63-68
18439571-0	2008	Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning.	Oxygen	83-89	hypoxia inducible factor 1, alpha subunit	Mus musculus	13-23
16357173-0	2005	Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1alpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.	Oxygen	105-111	hypoxia inducible factor 1, alpha subunit	Mus musculus	73-104
16357173-3	2005	The expression vector was constructed to express DT-A fused with hypoxia-inducible factor-1alpha (HIF-1alpha) oxygen-dependent degradation (ODD) domain under the control of vascular endothelial growth factor gene promoter and contain erythropoietin mRNA-binding protein (ERBP)-binding sequence downstream of the DT-A/ODD sequence.	Oxygen	110-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	65-96
16357173-3	2005	The expression vector was constructed to express DT-A fused with hypoxia-inducible factor-1alpha (HIF-1alpha) oxygen-dependent degradation (ODD) domain under the control of vascular endothelial growth factor gene promoter and contain erythropoietin mRNA-binding protein (ERBP)-binding sequence downstream of the DT-A/ODD sequence.	Oxygen	110-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	98-108
16357173-4	2005	In vitro ubiquitination assay showed that DT-A/ODD, but not DT-A, was ubiquitinated as efficient as HIF-1alpha under normoxic conditions in a von Hippel-Lindau- and oxygen-dependent manner.	Oxygen	165-171	hypoxia inducible factor 1, alpha subunit	Mus musculus	100-110
30573266-8	2019	Dependent on the applied cell concentration, the in vitro oxygen concentration (cO2) within the gels reached physiological ranges (7-9%) after 21 days, or 35 days of culture.	Oxygen	58-64	complement C2	Homo sapiens	80-83
16257553-6	2005	In gilthead sea bream larvae, the stressors-induced HSP70 and HSP90 (only in the reduced oxygen group) protein expression returned to unstressed levels after 24 h recovery.	Oxygen	89-95	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	52-57
18264140-5	2008	HBx induced deacetylation of the oxygen-dependent degradation domain of HIF-1 alpha, which was accompanied with dissociation of prolyl hydroxylases and von Hippel-Lindau tumor suppressor from HIF-1 alpha.	Oxygen	33-39	X protein	Hepatitis B virus	0-3
18426226-5	2008	Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine.	Oxygen	10-16	monoamine oxidase A	Homo sapiens	147-152
30573266-9	2019	The minimal cO2 was measured after 35 days in vitro, featuring an oxygen level of 4.8 +- 1.3%.	Oxygen	66-72	complement C2	Homo sapiens	12-15
18426226-5	2008	Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine.	Oxygen	76-78	monoamine oxidase A	Homo sapiens	147-152
30774348-0	2019	Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3beta/beta-catenin pathway.	Oxygen	11-17	glycogen synthase kinase 3 beta	Mus musculus	98-106
16242622-2	2005	GOD adsorbed on CdS nanoparticles maintained its bioactivity and structure, and could electro-catalyze the reduction of dissolved oxygen, which resulted in a great increase of the reduction peak current.	Oxygen	130-136	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
16291649-5	2005	We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions.	Oxygen	111-117	hypothetical protein	Escherichia coli	87-91
16291649-5	2005	We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions.	Oxygen	111-117	hypothetical protein	Escherichia coli	163-167
16280976-1	2005	PURPOSE: Methimazole (MMI), an anti-thyroid drug known to reduce serum levels of L-thyroxine (T4) and insulin-like growth factor-1 (IGF-1), has been previously reported to increase the incidence of neovascularization (NV) in an oxygen-induced retinopathy (OIR) model of retinopathy of prematurity (ROP) in rats.	Oxygen	228-234	insulin-like growth factor 1	Rattus norvegicus	132-137
18303027-2	2008	In metazoans, HIF-1alpha functions as a master regulator of oxygen homeostasis and regulates adaptive responses to change in oxygen tension during embryogenesis, tissue ischemia, and tumorigenesis.	Oxygen	60-66	hypoxia-inducible factor 1-alpha-like	Xenopus laevis	14-24
18303027-2	2008	In metazoans, HIF-1alpha functions as a master regulator of oxygen homeostasis and regulates adaptive responses to change in oxygen tension during embryogenesis, tissue ischemia, and tumorigenesis.	Oxygen	125-131	hypoxia-inducible factor 1-alpha-like	Xenopus laevis	14-24
18245082-4	2008	Accumulation of wild-type alpha-synuclein in the mitochondria of human dopaminergic neurons caused reduced mitochondrial complex I activity and increased production of reactive oxygen species.	Oxygen	177-183	synuclein alpha	Homo sapiens	26-41
30679577-3	2019	Compared to the conventional process of overnight oxidation, only ~10 s of oxygen/argon mixture plasma treatment is enough for the solar cell devices with FTO/ETL/perovskite/HTL/Au structure demonstrating a high power conversion efficiency.	Oxygen	75-81	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	155-158
18287216-5	2008	LTF was estimated in vivo using whole body plethysmography by exposing rat pups at postnatal days 1, 4, and 10 (P1, P4, and P10) to 10 brief hypoxic cycles (nadir 5% O2) and respiratory recordings during the following 2 h (recovery, 21% O2).	Oxygen	237-239	lactotransferrin	Rattus norvegicus	0-3
18287225-7	2008	The increased expression of UCP1 is likely an adaptive response to LTH, assuring adequate thermogenesis in the event of birth under oxygen-limiting conditions.	Oxygen	132-138	uncoupling protein 1	Homo sapiens	28-32
16283870-0	2005	Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes.	Oxygen	11-17	ATP binding cassette subfamily B member 4	Rattus norvegicus	63-93
30291880-5	2019	The present study investigated whether miR-21 could prevent hNSC injury induced by oxygen and glucose deprivation (OGD).	Oxygen	83-89	microRNA 21	Homo sapiens	39-45
16173744-1	2005	The mechanism for direct insertion of O(2) in a toluene-solvated palladium-hydride bond (avoiding palladium zero) has been elucidated using quantum mechanics (B3LYP/LACVP** with the PBF polarizable continuum solvent model) for Pd(II)(-)-sparteine)(Cl)(H) and the model compound Pd(II)(bipyridine)(Cl)(H).	Oxygen	38-42	zinc finger protein 395	Homo sapiens	182-185
18395045-1	2008	OBJECTIVE: The antiapoptotic action of heparin-binding epidermal growth factor (HBEGF)-like growth factor and its regulation by O(2) constitutes a key factor for trophoblast survival.	Oxygen	128-132	heparin binding EGF like growth factor	Homo sapiens	80-85
18336468-12	2008	CONCLUSION: They suggest that in vivo, in foetal lung low-oxygen environment, where PAF level is high, proliferation of PVSMC will occur readily to modulate PV development and that failure of down-regulation of PAF effects postnatally may result in PPHN.	Oxygen	58-64	PCNA clamp associated factor	Homo sapiens	84-87
30525413-2	2019	In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2).	Oxygen	154-160	doublecortin-like kinase 2	Mus musculus	136-139
15967517-9	2005	Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2.	Oxygen	77-83	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
30525413-2	2019	In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2).	Oxygen	154-160	doublecortin-like kinase 2	Mus musculus	190-193
30525413-4	2019	In-vitro experiments demonstrate that the HMON-[(Ru(dpp)3)]Cl2 can sensitively detect oxygen changes between 1% and 20%.	Oxygen	86-92	doublecortin-like kinase 2	Mus musculus	59-62
15994299-0	2005	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.	Oxygen	115-121	cytochrome b-245 alpha chain	Homo sapiens	46-53
18212270-5	2008	When AHR KO mice residing at 1632 m were exposed to the partial pressure of inspired oxygen (PIO(2)) at sea level for 11 days, blood pressure declined to levels measured at 225 m. Although plasma ET-1 in AHR KO mice was significantly elevated at 1632 m and decreased at 225 m and sea level PIO(2), pulmonary prepro-ET-1 mRNA was significantly reduced at 1632 m and decreased further at 225 m and sea level PIO(2).	Oxygen	85-91	endothelin 1	Mus musculus	196-200
30525413-5	2019	On this basis, photosensitizer chlorin e6 (Ce6) and [(Ru(dpp)3)]Cl2 are simultaneously loaded in the HMONs (denoted as HMON-Ce6-[(Ru(dpp)3)]Cl2) for real-time oxygen monitoring during photodynamic therapy.	Oxygen	159-165	doublecortin-like kinase 2	Mus musculus	64-67
18216035-10	2008	CONCLUSIONS: The haemoglobin-HO-1 system may be required to ensure adequate regulation of the bioavailability of haeme, iron and oxygen in human endometrium.	Oxygen	129-135	heme oxygenase 1	Homo sapiens	29-33
30525413-5	2019	On this basis, photosensitizer chlorin e6 (Ce6) and [(Ru(dpp)3)]Cl2 are simultaneously loaded in the HMONs (denoted as HMON-Ce6-[(Ru(dpp)3)]Cl2) for real-time oxygen monitoring during photodynamic therapy.	Oxygen	159-165	doublecortin-like kinase 2	Mus musculus	140-143
16115043-0	2005	Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress.	Oxygen	0-6	vascular endothelial growth factor A	Rattus norvegicus	38-42
30525413-6	2019	The HMON-Ce6-[(Ru(dpp)3)]Cl2 can reflects oxygen consumption in solution and cells in photodynamic therapy.	Oxygen	42-48	doublecortin-like kinase 2	Mus musculus	25-28
30525413-7	2019	Furthermore, the ability of the HMON-Ce6-[(Ru(dpp)3)]Cl2 nanosensor to monitor oxygen changes is demonstrated in tumor-bearing nude mice.	Oxygen	79-85	doublecortin-like kinase 2	Mus musculus	53-56
30241437-3	2019	We find that oxygen vacancies result in in-gap states that we use as input for single-band transport simulations.	Oxygen	13-19	regenerating family member 3 alpha	Homo sapiens	40-46
15800931-6	2005	At 5% O2, cells developed a weak hypoxic phenotype and HIF-2 alpha, but not HIF-1 alpha, was acutely stabilized.	Oxygen	6-8	endothelial PAS domain protein 1	Homo sapiens	55-66
15800931-7	2005	At 1% O2, HIF-2 alpha protein remained present in long-term cultures, while HIF-1 alpha was present only transiently.	Oxygen	6-8	endothelial PAS domain protein 1	Homo sapiens	10-21
17983831-6	2008	CONCLUSION: These results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1alpha.	Oxygen	100-106	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	217-230
17983831-6	2008	CONCLUSION: These results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1alpha.	Oxygen	100-106	hypoxia inducible factor 1, alpha subunit	Mus musculus	247-257
17983831-6	2008	CONCLUSION: These results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1alpha.	Oxygen	150-156	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	217-230
17983831-6	2008	CONCLUSION: These results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1alpha.	Oxygen	150-156	hypoxia inducible factor 1, alpha subunit	Mus musculus	247-257
18160403-6	2008	We report here that FTL and FTH are differentially regulated in 1% oxygen on a post-transcriptional level.	Oxygen	67-73	ferritin heavy chain 1	Homo sapiens	28-31
16124947-7	2005	Alkoxyphenols with at least two alkyl groups derivatized at alpha carbon of alkoxy group showed minimal rates of metabolism by tyrosinase/O2 metabolizing system.	Oxygen	138-140	tyrosinase	Mus musculus	127-137
15778277-9	2005	There was a decrease in lucigenin (5 x 10(-6) mol/l)-detectable O2- in gp91(phox)(-/-) mice compared with WT mice.	Oxygen	64-66	paired Ig-like receptor B	Mus musculus	71-75
30339838-4	2019	Prolyl hydroxylase domain (PHD)-2 protein, a major PHD in ECs, plays a critical role in intracellular oxygen homeostasis, angiogenesis, and pulmonary hypertension.	Oxygen	102-108	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-33
16298938-8	2005	In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways (ERK and Akt) and resulted in increased survival of irradiated cells in vitro.	Oxygen	86-92	fibroblast growth factor 20	Homo sapiens	21-27
18032381-3	2008	In relation to this, it is noted that the O-O stretching mode (nu(O-O)) of the oxygen complex of P450c21 was sensitive to the substrate; the progesterone- or 17alpha-hydroxyprogesterone-bound enzyme gave single (at 1137 cm(-1)) or split nu(O-O) bands (at 1124 and 1138 cm(-1)), respectively, demonstrating the presence of two forms for the latter.	Oxygen	79-85	steroid 21-hydroxylase	Bos taurus	97-104
21162184-10	2005	Its mechanism may involve oxidation damage in the rat hippocampal CA1 neurons, caused by sulfur- and oxygen-centered free radicals formed in the process of sulfite or bisulfite oxidation.	Oxygen	101-107	carbonic anhydrase 1	Rattus norvegicus	66-69
30468780-9	2019	These findings demonstrate that binding of HIF-2alpha to an oxygen-sensitive enhancer in intron 3 stimulates transcription of the WT1 gene in neuroblastoma cells by hypoxia-independent chromatin looping.	Oxygen	60-66	endothelial PAS domain protein 1	Homo sapiens	43-53
18334927-4	2008	With the assumption that variable oxygenation plays a role in RP forms related to pre-mRNA splicing and the retina and brain are similar, we searched a data collection of ischemia-hypoxia regulated genes of the brain for oxygen regulated genes of the U4/U6.U5 tri-snRNP complex.	Oxygen	34-40	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	264-269
16080711-3	2005	In this study, experimental results from a 3-D perfusion bioreactor system and the static culture are combined with a mathematical model to assess the effects of oxygen transport on hMSC metabolism and proliferation in 3-D constructs grown in static and perfusion conditions.	Oxygen	162-168	musculin	Homo sapiens	182-186
30651823-0	2019	Therapeutic effect of combined hyperbaric oxygen and radiation therapy for single brain metastasis and its influence on osteopontin and MMP-9.	Oxygen	42-48	secreted phosphoprotein 1	Homo sapiens	120-131
16027666-4	2005	However, to initiate prehospital analgesia earlier in the EMS response time frame, EMT"s should administer nitrous oxide/oxygen.	Oxygen	121-127	IL2 inducible T cell kinase	Homo sapiens	83-86
18361830-11	2008	CONCLUSION: Intestinal ischemia-reperfusion may result in intestinal mucosal damage, the mechanism may be involved in the release of abnormal TNF-alpha, NO, reactive oxygen and activated PMN; UTI can protect intestinal mucosal against intestinal ischemia-reperfusion injury, which may be associated with inhibiting the release of NO and TNF-a, ameliorating reactive oxygen damage, decreasing the aggregation and activation of PMN.	Oxygen	366-372	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	192-195
30255592-0	2019	Different response of human chondrocytes from healthy looking areas and damaged regions to IL1beta stimulation under different oxygen tension.	Oxygen	127-133	interleukin 1 alpha	Homo sapiens	91-98
18184809-1	2008	The hypoxia-inducible factor-1alpha (HIF-1alpha) pathway is the central regulator of adaptive responses to low oxygen availability and is required for normal skeletal development.	Oxygen	111-117	hypoxia inducible factor 1, alpha subunit	Mus musculus	4-35
18184809-1	2008	The hypoxia-inducible factor-1alpha (HIF-1alpha) pathway is the central regulator of adaptive responses to low oxygen availability and is required for normal skeletal development.	Oxygen	111-117	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-47
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Oxygen	118-124	ceruloplasmin	Mus musculus	263-276
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Oxygen	181-187	ceruloplasmin	Mus musculus	263-276
30255592-14	2019	Oxygen tension may profoundly and differentially influence inflammation-associated cartilage injury and diseases by regulating the expression of HIF1alpha and HIF2alpha.	Oxygen	0-6	endothelial PAS domain protein 1	Homo sapiens	159-168
17934062-4	2008	MV of newborn mice for 8 h with either 40% O2 or air increased lung mRNA for tropoelastin and lysyl oxidase, relative to unventilated controls, without increasing lung expression of genes that regulate elastic fiber assembly (lysyl oxidase-like-1, fibrillin-1, fibrillin-2, fibulin-5, emilin-1).	Oxygen	43-45	elastin	Mus musculus	77-89
16054088-5	2005	These results provide genetic evidence indicating that mtROS act upstream of prolyl hydroxylases in regulating HIF-1 alpha and HIF-2 alpha in this O(2)-sensing pathway.	Oxygen	147-151	endothelial PAS domain protein 1	Homo sapiens	127-138
30512923-8	2018	IDPC@Zr-PEG nanocomposites can produce oxygen in the tumor microenvironment during the course of tumor treatment, thereby alleviating the hypoxic state and improving the therapeutic effect.	Oxygen	39-45	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
16054089-4	2005	These results demonstrate that mitochondria function as O(2) sensors and signal hypoxic HIF-1 alpha and HIF-2 alpha stabilization by releasing ROS to the cytosol.	Oxygen	56-60	endothelial PAS domain protein 1	Homo sapiens	104-115
15888316-0	2005	Effect of oxidative stress on translocation of DAF-16 in oxygen-sensitive mutants, mev-1 and gas-1 of Caenorhabditis elegans.	Oxygen	57-63	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	47-53
15888316-1	2005	Mutations in the mev-1 and gas-1 genes of the nematode Caenorhabditis elegans render animals hypersensitive to oxygen and paraquat, and lead to premature aging.	Oxygen	111-117	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	27-32
15857155-5	2005	These results also suggest the possibility of iatrogenic exacerbation of acute lung injury upon oxygen administration due to the oxygenation-associated elimination of A2AR-mediated lung tissue-protecting pathway.	Oxygen	96-102	adenosine A2a receptor	Homo sapiens	167-171
17936496-9	2008	The oxygen-dependent reduction of Epo-R can account for the associated cytotoxicity at 2% O(2).	Oxygen	4-10	erythropoietin receptor	Homo sapiens	34-39
17936496-9	2008	The oxygen-dependent reduction of Epo-R can account for the associated cytotoxicity at 2% O(2).	Oxygen	90-94	erythropoietin receptor	Homo sapiens	34-39
18071656-4	2008	This review focuses on the role(s) of TLR2 and Dectin-1 in triggering inflammatory responses, transcription factor activation, phagocytosis, and reactive oxygen production in response to fungi.	Oxygen	154-160	C-type lectin domain containing 7A	Homo sapiens	47-55
18004410-2	2007	Four IR bands were observed at 3644, 3616, 3575 and 3538 cm(-1), and they were ascribable to the acidic OH groups on four nonequivalent oxygen sites in the CHA structure.	Oxygen	136-142	transcription factor like 5	Homo sapiens	156-159
30422640-1	2018	The molecular mechanism of O2 binding to hemoglobin (Hb) and myoglobin (Mb) is a long-standing issue in the field of bioinorganic and biophysical chemistry.	Oxygen	27-29	myoglobin	Homo sapiens	61-70
18062818-3	2007	Here we investigated on the effect of N-acetylcysteine (NAC), on gp120-induced damage in human cultured astroglial cells and the possible contribution of gp120-related reacting oxygen species (ROS) in the imbalanced activity of glutamine synthase (GS), the enzyme that metabolizes glutamate into glutamine within astroglial cells playing a neuroprotective role in brain disorders.	Oxygen	177-183	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
15923322-8	2005	Ethylene signaling mutants (ein2 and etr1) and reactive oxygen metabolism mutants (vtc1, vtc2, npq1, and cad2) were more defective in basal than acquired thermotolerance, especially under high light.	Oxygen	56-62	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	83-87
15923322-8	2005	Ethylene signaling mutants (ein2 and etr1) and reactive oxygen metabolism mutants (vtc1, vtc2, npq1, and cad2) were more defective in basal than acquired thermotolerance, especially under high light.	Oxygen	56-62	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	89-93
29947255-4	2018	We aimed to investigate the effects of APN on oxygen and glucose deprivation (OGD)-induced neuronal injury in hippocampal neuronal HT22 cells.	Oxygen	46-52	adiponectin, C1Q and collagen domain containing	Mus musculus	39-42
15883259-12	2005	Stratification of the results by mutation suggests that the 11778/ND4 mutation may induce an uncoupling of cybrid respiration, whereas the other 2 mutations impair the oxygen consumption rate.	Oxygen	168-174	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	66-69
15926920-5	2005	In four age groups (E18-P2, P8-P12, P16-P20, &gt; or = P28), unstimulated neurons showed a significant age-dependent increase in basal oxygen consumption (6.1 up to 10.2 nM/min/10(7) cells).	Oxygen	135-141	golgi SNAP receptor complex member 1	Rattus norvegicus	55-58
17592963-8	2007	RESULTS: There was minimal oxygen-dependent change in HIF-1 alpha levels and no change in gal-3 expression and promoter activity in nucleus pulposus cells.	Oxygen	27-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	54-65
29683360-2	2018	Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Abeta injection-induced cognitive dysfunction.	Oxygen	99-105	amyloid beta (A4) precursor protein	Mus musculus	156-161
17985857-3	2007	Annealing allows the dioxygen molecules to diffuse and to react with FeO2 and form the side-on and end-on bonded dioxygen-iron dioxide complexes, (eta2-O2)FeO2 and (eta1-O2)FeO2.	Oxygen	21-29	secreted phosphoprotein 1	Homo sapiens	165-169
17985857-3	2007	Annealing allows the dioxygen molecules to diffuse and to react with FeO2 and form the side-on and end-on bonded dioxygen-iron dioxide complexes, (eta2-O2)FeO2 and (eta1-O2)FeO2.	Oxygen	113-121	secreted phosphoprotein 1	Homo sapiens	165-169
17985857-6	2007	These two isomers are photoreversible, that is, near-infrared light (lambda &gt; 850 nm) induces the conversion of the side-on bonded (eta2-O2)FeO2 complex to the end-on bonded (eta1-O2)FeO2 isomer and vice versa with red light irradiation (lambda &gt; 600 nm).	Oxygen	140-142	secreted phosphoprotein 1	Homo sapiens	178-182
15885101-0	2005	Dual role of oxygen during lipoxygenase reactions.	Oxygen	13-19	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	27-39
15850924-3	2005	METHODS AND MATERIALS: The influence of radiation (5 Gy) and hypoxia (1% O2) on reporter-gene expression driven by hypoxia (HRE) and radiation (Egr-1) responsive elements was evaluated in tumor cells grown as monolayers or multicellular spheroids.	Oxygen	73-75	early growth response 1	Homo sapiens	144-149
30073566-0	2018	Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-kappaB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes.	Oxygen	11-17	C-C motif chemokine ligand 2	Homo sapiens	108-112
15810856-2	2005	Reactions of d0 amides M(NMe2)4 (M = Zr, 1; Hf, 2) with O2 have been found to yield unusual trinuclear oxo aminoxide complexes M3(NMe2)6(mu-NMe2)3(mu3-O)(mu3-ONMe2) (M = Zr, 3; Hf, 4) in high yields.	Oxygen	56-58	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	25-29
15810856-2	2005	Reactions of d0 amides M(NMe2)4 (M = Zr, 1; Hf, 2) with O2 have been found to yield unusual trinuclear oxo aminoxide complexes M3(NMe2)6(mu-NMe2)3(mu3-O)(mu3-ONMe2) (M = Zr, 3; Hf, 4) in high yields.	Oxygen	56-58	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	130-134
17960903-6	2007	Second, the oxygen equilibrium isotope effect upon O2 binding to copper(I) (18O EIE [triple bond] K(16O16O)/K(16O18O) = 1.0148 +/- 0.0012) is significantly larger than those determined for iron and cobalt eta1-O2 adducts.	Oxygen	12-18	secreted phosphoprotein 1	Homo sapiens	205-209
17960903-6	2007	Second, the oxygen equilibrium isotope effect upon O2 binding to copper(I) (18O EIE [triple bond] K(16O16O)/K(16O18O) = 1.0148 +/- 0.0012) is significantly larger than those determined for iron and cobalt eta1-O2 adducts.	Oxygen	51-53	secreted phosphoprotein 1	Homo sapiens	205-209
21730489-3	2007	With the support of XPS measurements, the following photoactivation mechanism is proposed: Cd(2+) ions are released from the CdS surface owing to slow photocorrosion in the presence of oxygen, and Cd-OH bond formation occurs on the CdS surface under the alkaline conditions, removing the surface trap states.	Oxygen	185-191	CDP-diacylglycerol synthase 1	Homo sapiens	125-128
15810856-2	2005	Reactions of d0 amides M(NMe2)4 (M = Zr, 1; Hf, 2) with O2 have been found to yield unusual trinuclear oxo aminoxide complexes M3(NMe2)6(mu-NMe2)3(mu3-O)(mu3-ONMe2) (M = Zr, 3; Hf, 4) in high yields.	Oxygen	56-58	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	130-134
29903683-0	2018	Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).	Oxygen	12-18	ubiquitin C-terminal hydrolase L1	Homo sapiens	95-128
15833036-6	2005	The addition of CP to AA (mM) solutions accelerated oxygen consumption by AA and caused CP copper ion release and loss of ferroxidase and aminoxidase activities.	Oxygen	52-58	ceruloplasmin	Homo sapiens	16-18
15802346-6	2005	CCL2 levels correlated negatively with the carbon monoxide diffusing capacity of the lung (D(L,CO)) and arterial oxygen tension.	Oxygen	113-119	C-C motif chemokine ligand 2	Homo sapiens	0-4
17941656-3	2007	The PDI radical anions formed within the films were rather stable, persisting for several minutes in the presence of atmospheric oxygen.	Oxygen	129-135	peptidyl arginine deiminase 1	Homo sapiens	4-7
18056950-4	2007	Maintenance of WI38 and IMR90 cells in 1.5% or 3% O(2) concentration significantly delayed the appearance of replicative senescence compared to cells grown in 20% O(2), induced the hypoxia-inducible factor-1alpha, and resulted in reduced expression levels of the key cell cycle modulators, namely p21 and p16.	Oxygen	50-54	H3 histone pseudogene 16	Homo sapiens	297-300
29903683-0	2018	Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).	Oxygen	12-18	ubiquitin C-terminal hydrolase L1	Homo sapiens	130-136
29903683-1	2018	OBJECTIVE: The authors sought to assess the relationship between low oxygen delivery (DO2) during cardiopulmonary bypass (CPB) and a neuron-specific biomarker of neurologic injury, ubiquitin C-terminal hydrolase L1 (UCH-L1).	Oxygen	69-75	ubiquitin C-terminal hydrolase L1	Homo sapiens	181-214
17674027-7	2007	The highest muscular efficiency was found at 80 rpm in the two experiments, whereas a remarkable reduction (19%) in muscular efficiency obtained at 120 rpm could be attributable to greater O2 cost due to higher levels of Pint accompanying the increased pedal rates.	Oxygen	189-191	long intergenic non-protein coding RNA, p53 induced transcript	Homo sapiens	221-225
16097692-4	2005	This spectral feature reveals that H3L2+ gradually lost hydrogen ion combined on C-4 keto oxygen.	Oxygen	90-96	complement C4A (Rodgers blood group)	Homo sapiens	81-84
29903683-1	2018	OBJECTIVE: The authors sought to assess the relationship between low oxygen delivery (DO2) during cardiopulmonary bypass (CPB) and a neuron-specific biomarker of neurologic injury, ubiquitin C-terminal hydrolase L1 (UCH-L1).	Oxygen	69-75	ubiquitin C-terminal hydrolase L1	Homo sapiens	216-222
30371059-3	2018	Herein, we demonstrate a preformed cation-mixed ( Fm3 m) surface nanolayer (~5 nm) that shares a consistent oxygen framework with the layered lattice through Zr modification, in which Ni cations reside in Li slabs and play the role of a "pillar".	Oxygen	108-114	neuromedin U receptor 1	Homo sapiens	50-53
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	Oxygen	248-250	transcription factor Dp-2	Homo sapiens	191-194
17916248-16	2007	Ten globins are responsive to oxygen deprivation in an interacting HIF-1 and DAF-16 dependent manner.	Oxygen	30-36	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	77-83
30203428-0	2018	An Efficient Anti-poisoning Catalyst against SOx , NOx , and POx : P, N-Doped Carbon for Oxygen Reduction in Acidic Media.	Oxygen	89-95	proline dehydrogenase 1	Homo sapiens	61-64
15540202-2	2005	Our objective was to determine the role that oxygen tension plays on the direct tumor effect of endostatin (ES).	Oxygen	45-51	collagen type XVIII alpha 1 chain	Homo sapiens	96-106
30395586-8	2018	In agreement, expression of the lncRNA MEG3 (Maternally Expressed 3; Meg3/Gtl2), cultured at 21 and 3% [O2], was also significantly higher in PL than in PS passages.	Oxygen	104-106	maternally expressed 3	Homo sapiens	39-43
15755139-1	2005	Nanocrystalline CeO2 supplies reactive oxygen in the form of surface eta1 superoxide species and peroxide adspecies at the one-electron defect site to the supported active species of gold for the oxidation of CO.	Oxygen	39-45	secreted phosphoprotein 1	Homo sapiens	69-73
17715993-5	2007	A 12 h oxidation of the iridium tip in an oxygen atmosphere gives in a stable pH response.	Oxygen	42-48	TOR signaling pathway regulator	Homo sapiens	32-35
30395586-8	2018	In agreement, expression of the lncRNA MEG3 (Maternally Expressed 3; Meg3/Gtl2), cultured at 21 and 3% [O2], was also significantly higher in PL than in PS passages.	Oxygen	104-106	maternally expressed 3	Homo sapiens	69-73
30395586-8	2018	In agreement, expression of the lncRNA MEG3 (Maternally Expressed 3; Meg3/Gtl2), cultured at 21 and 3% [O2], was also significantly higher in PL than in PS passages.	Oxygen	104-106	maternally expressed 3	Homo sapiens	74-78
17879999-10	2007	These proteins have been reported with their important roles in microparticles in human blood cells: vWF is a platelet and endothelial cell product that binds to P-selectin, GP1b, and GP IIb/IIIa, and beta-globin is one of the peptides of hemoglobin involved in the transportation of oxygen by red blood cells.	Oxygen	284-290	selectin P	Homo sapiens	162-172
30040951-0	2018	Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice.	Oxygen	88-94	sirtuin 1	Mus musculus	0-5
17878296-7	2007	Compared with other Ca(2+)-binding proteins, both sites in NaK present a novel mode of Ca(2+) chelation, using only backbone carbonyl oxygen atoms from residues in the selectivity filter.	Oxygen	134-140	TANK binding kinase 1	Homo sapiens	59-62
15626716-2	2005	L35, a bezafibrate-related compound, is one of the more potent synthetic regulators of Hb oxygen (O(2)) affinity.	Oxygen	90-96	ribosomal protein L35	Homo sapiens	0-3
15626716-2	2005	L35, a bezafibrate-related compound, is one of the more potent synthetic regulators of Hb oxygen (O(2)) affinity.	Oxygen	98-103	ribosomal protein L35	Homo sapiens	0-3
15753051-9	2005	Pulmonary complications caused by G-CSF include cough, dyspnea, and interstitial or alveolar pulmonary edema with mild-to-severe deterioration of blood oxygen level.	Oxygen	152-158	colony stimulating factor 3	Homo sapiens	34-39
30230496-4	2018	The octa-coordination is completed by an oxygen atom of a neighboring carboxylate group, which bridges Bi(iii) ions thanks to mu2-eta1:eta1 coordination, resulting in the formation of a coordination polymer.	Oxygen	41-47	secreted phosphoprotein 1	Homo sapiens	130-134
15637297-0	2005	A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase.	Oxygen	136-142	nitric oxide synthase 3, endothelial cell	Mus musculus	184-217
15637297-1	2005	Endothelial nitric oxide synthase (eNOS) plays an important role in the control of myocardial oxygen consumption (MVO2) by nitric oxide (NO).	Oxygen	94-100	nitric oxide synthase 3, endothelial cell	Mus musculus	0-33
17704763-7	2007	Furthermore, the ZTL-GI interaction is strongly and specifically enhanced by blue light, through the amino-terminal flavin-binding LIGHT, OXYGEN OR VOLTAGE (LOV) domain of ZTL.	Oxygen	138-144	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	17-20
17704763-7	2007	Furthermore, the ZTL-GI interaction is strongly and specifically enhanced by blue light, through the amino-terminal flavin-binding LIGHT, OXYGEN OR VOLTAGE (LOV) domain of ZTL.	Oxygen	138-144	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	172-175
17462705-7	2007	Low-temperature EC1 (550 degrees C in a 98% He/2% O2 atmosphere) is more abundant for char samples.	Oxygen	50-52	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	16-19
18018756-1	2007	Heliox is a low density gas mixture of helium and oxygen commonly used in deep diving (&gt; 6 ATM).	Oxygen	50-56	ATM serine/threonine kinase	Homo sapiens	94-97
17676735-3	2007	To help develop such processes, we elucidate here the mechanism for the reaction of molecular oxygen with toluene-solvated palladium-hydride complex using quantum mechanics (B3LYP/LACVP** with the PBF polarizable continuum solvent model) for Pd(II-)((-)sparteine)(H)(Cl) in the presence of base, specifically focusing on the pathways proceeding through Pd(0).	Oxygen	94-100	zinc finger protein 395	Homo sapiens	197-200
15859286-4	2005	Upon treatment of [ReV(NPh)Cl3(PPh3)2] with L1OH in solution, the neutral azoimine complex [ReV(NPh)Cl3(L1H)], 3, resulted due to the spontaneous transfer of the oxime oxygen atom to a PPh3 ligand, which is eliminated as OPPh3.	Oxygen	168-174	protein phosphatase 4 catalytic subunit	Homo sapiens	31-35
15475598-7	2005	In fibroblasts cultured from chronically hypoxic animals, exposure to 1% oxygen upregulated Egr-1 protein and cell proliferation.	Oxygen	73-79	early growth response 1	Homo sapiens	92-97
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Oxygen	111-117	protein phosphatase 4 catalytic subunit	Homo sapiens	102-106
30230496-4	2018	The octa-coordination is completed by an oxygen atom of a neighboring carboxylate group, which bridges Bi(iii) ions thanks to mu2-eta1:eta1 coordination, resulting in the formation of a coordination polymer.	Oxygen	41-47	secreted phosphoprotein 1	Homo sapiens	135-139
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Oxygen	111-117	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Oxygen	111-117	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
17671895-4	2007	Administration of SMA-pirarubicin micelle under HBO can further enhance the delivery of molecular oxygen that facilitates tumor selective generation of ROS, thus augmenting its antitumor potency.	Oxygen	98-104	immunoglobulin mu binding protein 2	Mus musculus	18-21
29920361-6	2018	As demonstrated by Western Blot Analysis, Caspase 8 cleavage and Caspase 3 cleavage in CCN6-depleted cells exceeded the control group treated with high oxygen (48 h).	Oxygen	152-158	cellular communication network factor 6	Homo sapiens	87-91
15656973-1	2005	Dinoflagellate luciferase (DL) catalyses the oxidation of dinoflagellate luciferin by molecular oxygen, resulting in an electronically excited species that emits blue light (lambda(max)=474 nm).	Oxygen	96-102	ddl	Drosophila melanogaster	27-29
29957292-4	2018	Under this condition, the chemical oxygen demand (COD) removal efficiency, dehydrogenase activities, and the viability of microorganisms reached 62.7%, 55.7 TF muL-1, and 78.4%, respectively, which were 115.4%, 77.2%, and 20.3% higher than those without the addition of potassium chloride.	Oxygen	35-41	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	160-165
16594153-1	2005	The CAS neonatal NIRS system determines absolute regional brain tissue oxygen saturation (SnO2) and brain true venous oxygen saturation (SnvO2) non-invasively.	Oxygen	71-77	BCAR1 scaffold protein, Cas family member	Homo sapiens	4-7
16594160-4	2005	The rate of decline in PO2 following occlusion yielded a calculated initial flux of oxygen out of the vessel lumen of 8.0 x 10(-7) ml O2 cm(-2) sec(-1).	Oxygen	84-90	secretory blood group 1	Rattus norvegicus	144-150
16594160-6	2005	This value was 2.5 x 10(-3) ml O2 cm(-3) sec(-1) and is an overestimate since the oxygen consumption of the nearby parenchymal cells was neglected.	Oxygen	82-88	secretory blood group 1	Rattus norvegicus	41-47
17529908-5	2007	Exogenous ROI (either hydrogen peroxide or O2 generated by xanthine/xanthine oxidase) stimulated MCP-1 production, which was also inhibited by DMSO.	Oxygen	43-45	C-C motif chemokine ligand 2	Homo sapiens	97-102
17926914-5	2007	Moreover, PPARA G (when oxygen pulse was measured) and PGC 1A Gly (when maximal aerobic power and anaerobic threshold (%) of VO2max were measured) alleles were associated with high values of aerobic performance.	Oxygen	24-30	peroxisome proliferator activated receptor alpha	Homo sapiens	10-15
16594160-7	2005	The calculated maximum oxygen consumption of the wall is more than an order of magnitude smaller than that reported previously for arterioles in the rat mesentery (6.5 x 10(-2) ml O2 cm(-3) sec(-1)).	Oxygen	23-29	secretory blood group 1	Rattus norvegicus	190-196
30100034-9	2018	Furthermore, alpha7nAChR blockade before capsaicin exacerbated LIRI as evidenced by enhanced alveolar-arterial oxygen gradient, pathologic score, and IL1beta, IL6, and TNFalpha levels, while alpha7nAChR agonist pretreatment under TRPV1 blockade showed opposite changes.	Oxygen	111-117	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	13-24
17281509-3	2005	Within a few minutes, a cable car facilitates an ascent from 1702 m to 2700 m above sea level, where the partial pressure of oxygen is about 550 mmHg (as compared to 760 mmHg at sea level).	Oxygen	125-131	CXADR pseudogene 1	Homo sapiens	30-33
17617567-4	2007	In this study, we demonstrate that the CD56(bright) subset of NK cells, in contrast to CD56(dim) cells, remains viable and functionally intact after exposure to phagocyte-derived or exogenously added oxygen radicals.	Oxygen	200-206	neural cell adhesion molecule 1	Homo sapiens	39-43
30101584-0	2018	Highly Dispersed Co-B/N Codoped Carbon Nanospheres on Graphene for Synergistic Effects as Bifunctional Oxygen Electrocatalysts.	Oxygen	103-109	metabolism of cobalamin associated B	Homo sapiens	17-21
17612411-0	2007	Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes.	Oxygen	36-42	NADPH oxidase	Drosophila melanogaster	69-72
17281509-3	2005	Within a few minutes, a cable car facilitates an ascent from 1702 m to 2700 m above sea level, where the partial pressure of oxygen is about 550 mmHg (as compared to 760 mmHg at sea level).	Oxygen	125-131	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	84-87
17281509-3	2005	Within a few minutes, a cable car facilitates an ascent from 1702 m to 2700 m above sea level, where the partial pressure of oxygen is about 550 mmHg (as compared to 760 mmHg at sea level).	Oxygen	125-131	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	178-181
17281671-8	2005	The derived information of DO2 and DCO2 as well as of O2 and CO2 metabolic rates can be of considerable clinical use including for SARS assessment.	Oxygen	28-30	seryl-tRNA synthetase 1	Homo sapiens	131-135
28867175-8	2018	There was a significant negative correlation between oxygen saturation, plasma P-selectin (r=-0.865), E-selectin (r=-0.401), and PF4 (r=-0.792) in patients with CCHD.	Oxygen	53-59	selectin P	Homo sapiens	79-89
15598505-2	2005	Indeed, modern O2-transporting and storing mammalian red blood cell Hb and related muscle myoglobin (Mb) show vestigial *NO dioxygenation activity with rate constants of 34-89 microM(-1) s(-1).	Oxygen	15-17	myoglobin	Homo sapiens	90-99
17511584-10	2007	Here we discuss how TRX is useful as a biomarker of and therapeutic agent for cardiopulmonary disorders, especially focusing on ischemic heart disease, myocarditis and oxygen sensing, and acute respiratory distress syndrome.	Oxygen	168-174	thioredoxin	Homo sapiens	20-23
17650380-1	2007	The ability to quantify the contributions of hemoglobin (Hb) and myoglobin (Mb) to in vivo optical spectra has many applications for clinical and research use such as noninvasive measurement of local tissue O(2) uptake rates and regional blood content.	Oxygen	207-211	myoglobin	Homo sapiens	65-74
17650380-1	2007	The ability to quantify the contributions of hemoglobin (Hb) and myoglobin (Mb) to in vivo optical spectra has many applications for clinical and research use such as noninvasive measurement of local tissue O(2) uptake rates and regional blood content.	Oxygen	207-211	myoglobin	Homo sapiens	76-78
17650380-2	2007	Recent work has demonstrated an approach to independently measure oxygen saturations of Hb and Mb in optical spectra collected in vivo.	Oxygen	66-72	myoglobin	Homo sapiens	95-97
16291250-5	2005	However, in cells surviving the toxicity caused by lower doses of O2-, NO, or ONOO-, the depleted intracellular GSH level was replenished, and HO-1 expression was increased, but not when they were coexposed to an inhibitor of HO-1 activity.	Oxygen	66-68	heme oxygenase 1	Homo sapiens	143-147
16291250-5	2005	However, in cells surviving the toxicity caused by lower doses of O2-, NO, or ONOO-, the depleted intracellular GSH level was replenished, and HO-1 expression was increased, but not when they were coexposed to an inhibitor of HO-1 activity.	Oxygen	66-68	heme oxygenase 1	Homo sapiens	226-230
16291250-8	2005	Thus, the dichotomous cytotoxic or cytoprotective effects of O2-, NO, or ONOO- in macrophages are determined both by cellular GSH level and by HO-1 activity.	Oxygen	61-63	heme oxygenase 1	Homo sapiens	143-147
16344151-10	2005	Judged by propidium iodide uptake, a selective CA1 lesion, with only minor affection on CA3, occurred in cultures exposed to oxygen-glucose deprivation for 30 min.	Oxygen	125-131	carbonic anhydrase 1	Rattus norvegicus	47-50
16344152-4	2005	The mitogen-activated protein kinases extracellular signal-regulated kinase 1 and extracellular signal-regulated kinase 2 were activated immediately after oxygen and glucose deprivation both in CA1 and in CA3/fascia dentata.	Oxygen	155-161	carbonic anhydrase 1	Rattus norvegicus	194-197
17442338-4	2007	Indeed, in addition to the interactions found in all other AKRs (van der Waals contacts stabilizing the core of the steroid and the hydrogen bonds established at the catalytic site by the Y55 and H117 residues with the oxygen atom of the ketone group to be reduced), m17alpha-HSD establishes with the other extremity of the steroid nucleus an additional interaction involving K31.	Oxygen	219-225	keratin 31	Mus musculus	376-379
29396649-7	2018	By using CPT1A floxed mice, we have observed that genetic ablation of CPT1A recapitulates the effect of ghrelin on GABA release in cortical neurons, inducing reductions in mitochondrial oxygen consumption, cell content of citrate and alpha-ketoglutarate, and GABA shunt enzyme activity.	Oxygen	186-192	carnitine palmitoyltransferase 1a, liver	Mus musculus	70-75
17436234-7	2007	Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy.	Oxygen	189-195	C-C motif chemokine ligand 4	Homo sapiens	71-114
15672859-7	2005	Plasma OPN levels inversely and closely correlated with arterial oxygen tension (PaO2) in patients with IP.	Oxygen	65-71	secreted phosphoprotein 1	Homo sapiens	7-10
30105344-2	2018	Herein, two new kinds of Ni (POxN3-x)2/NPC and Co (POxN3-x)2/NPC (NPC: N, P-co-doped carbon) are synthesized through a facile post-treatment of nickel- or cobalt-phytic acid xerogel, followed by an annealing procedure under an argon and ammonia atmosphere at 800  C. The as-prepared catalysts exhibit outstanding catalytic activities for both the oxygen reduction and evolution reactions, which are comparable to those of Pt/C and IrO2.	Oxygen	347-353	NPC intracellular cholesterol transporter 1	Homo sapiens	29-49
15625007-4	2004	Accordingly, the activation of human neutrophil FPR and FPRL1 induces identical, pertussis toxin-sensitive functional responses and a transient increase in intracellular calcium is followed by a secretory response leading to mobilization of receptors from intracellular stores, as well as a release of reactive oxygen metabolites.	Oxygen	311-317	formyl peptide receptor 2	Homo sapiens	56-61
17390074-5	2007	Both hypoxia and reoxygenation induced statistically significant changes in uPA, PAI-1 and uPAR mRNA and protein levels in the various cell lines investigated, showing that oxygen tension is a strong modulator of the plasminogen activation system in vitro.	Oxygen	19-25	serpin family E member 1	Homo sapiens	81-86
17390074-5	2007	Both hypoxia and reoxygenation induced statistically significant changes in uPA, PAI-1 and uPAR mRNA and protein levels in the various cell lines investigated, showing that oxygen tension is a strong modulator of the plasminogen activation system in vitro.	Oxygen	19-25	plasminogen activator, urokinase receptor	Homo sapiens	91-95
30105344-2	2018	Herein, two new kinds of Ni (POxN3-x)2/NPC and Co (POxN3-x)2/NPC (NPC: N, P-co-doped carbon) are synthesized through a facile post-treatment of nickel- or cobalt-phytic acid xerogel, followed by an annealing procedure under an argon and ammonia atmosphere at 800  C. The as-prepared catalysts exhibit outstanding catalytic activities for both the oxygen reduction and evolution reactions, which are comparable to those of Pt/C and IrO2.	Oxygen	347-353	NPC intracellular cholesterol transporter 1	Homo sapiens	29-42
30125331-2	2018	Here, we found that NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to possess N-acetylglucosamine (GlcNAc) transferase activity, GlcNAcylates HIF-1alpha, a master regulator of cellular O2 homeostasis.	Oxygen	229-231	hypoxia inducible factor 1, alpha subunit	Mus musculus	186-196
17358072-1	2007	[reaction: see text] beta-C-galacto-Pyranosides with CHF and CF2 substitutes for the glycosidic oxygen were prepared through a four-step sequence starting from a central 1-thio-1,2-O-isopropylidene acetal alcohol and different alpha-fluoro- and alpha,alpha-difluoro acids.	Oxygen	96-102	colony stimulating factor 2 receptor subunit beta	Homo sapiens	21-27
15575754-2	2004	In fact, the reaction of 7, easily prepared by reaction of 5"-O-Tosyl TSAO-T under basic nonnucleophilic conditions (potassium carbonate), with different classes of nucleophiles, for example, nitrogen-, oxygen-, sulfur-, and carbon-based nucleophiles, or with amino acids afforded, with total regio- and stereoselectivity, new bi-, tri-, and tetracyclic nucleosides.	Oxygen	203-209	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	332-335
15485853-7	2004	COS-7 cells co-transfected with Gyc-88E and Gyc-89Da or Gyc-89Db accumulate low levels of cGMP under normal atmospheric oxygen concentrations and are potently activated under anoxic conditions.	Oxygen	120-126	Guanylyl cyclase at 89Db	Drosophila melanogaster	56-64
15485853-9	2004	Gyc-88E and Gyc-89Db are co-expressed in a subset of sensory neurons where they would be ideally situated to act as oxygen sensors.	Oxygen	116-122	Guanylyl cyclase at 89Db	Drosophila melanogaster	12-20
29978709-0	2018	Real-Time Sensing of TET2-Mediated DNA Demethylation In Vitro by Metal-Organic Framework-Based Oxygen Sensor for Mechanism Analysis and Stem-Cell Behavior Prediction.	Oxygen	95-101	tet methylcytosine dioxygenase 2	Mus musculus	21-25
15347560-3	2004	A neutrophil chemokine, cytokine-induced neutrophil chemoattractant-1, which signals through the neutrophil CXC chemokine receptor-2, is increased in the lung tissue of newborn rats exposed to 60% oxygen.	Oxygen	197-203	C-X-C motif chemokine ligand 1	Rattus norvegicus	24-69
15642322-9	2004	Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR).	Oxygen	98-100	peroxiredoxin 5	Homo sapiens	161-165
15642322-0	2004	Thioredoxin reductase may be essential for the normal growth of hyperbaric oxygen-treated human lens epithelial cells.	Oxygen	75-81	peroxiredoxin 5	Homo sapiens	0-21
15642322-7	2004	In contrast, the activity of thioredoxin reductase (TrxR) was severely affected by the O2, decreasing by 51% after the 3 hr exposure.	Oxygen	87-89	peroxiredoxin 5	Homo sapiens	29-50
15642322-7	2004	In contrast, the activity of thioredoxin reductase (TrxR) was severely affected by the O2, decreasing by 51% after the 3 hr exposure.	Oxygen	87-89	peroxiredoxin 5	Homo sapiens	52-56
15642322-9	2004	Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR).	Oxygen	98-100	heme oxygenase 1	Homo sapiens	126-142
15642322-9	2004	Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR).	Oxygen	98-100	heme oxygenase 1	Homo sapiens	144-148
15563179-0	2004	NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme.	Oxygen	71-77	immunoglobulin kappa variable 1D-22 (pseudogene)	Homo sapiens	85-93
17270308-3	2007	GOX delivery results in conversion of glucose and oxygen into H(2)O(2) leading to lung damage, a clear physiologic endpoint.	Oxygen	50-56	hydroxyacid oxidase 1, liver	Mus musculus	0-3
17389509-12	2007	CONCLUSIONS: Segregation of the susceptibility trait to oxygen-induced retinopathy in the DA and F344 rat strains is associated with pigmentation and erythropoietin expression and can be modeled using an autosomal dominant pattern of inheritance.	Oxygen	56-62	erythropoietin	Rattus norvegicus	150-164
17234685-1	2007	D-aspartate oxidase (DDO, EC 1.4.3.1) catalyzes dehydrogenation of D-aspartate to iminoaspartate and the subsequent re-oxidation of reduced FAD with O2 to produce hydrogen peroxide.	Oxygen	149-151	D-aspartate oxidase	Homo sapiens	0-19
17439697-1	2007	Hyperbaric oxygen (HBO) therapy is defined by the Undersea and Hyperbaric Medical Society (UHMS) as a treatment in which a patient intermittingly breathes 100% oxygen under a pressure that is greater than the pressure at sea level [a pressure greater than 1 atmosphere absolute (ATA)].	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
29978709-3	2018	Here, by a metal-organic framework (MOF)-based optical O2 sensor, we present the first demonstration on real-time TET2 kinetics assay in vitro.	Oxygen	55-57	tet methylcytosine dioxygenase 2	Mus musculus	114-118
17439697-1	2007	Hyperbaric oxygen (HBO) therapy is defined by the Undersea and Hyperbaric Medical Society (UHMS) as a treatment in which a patient intermittingly breathes 100% oxygen under a pressure that is greater than the pressure at sea level [a pressure greater than 1 atmosphere absolute (ATA)].	Oxygen	160-166	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	55-58
15328343-8	2004	Together, these studies indicate that PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response.	Oxygen	100-106	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	152-157
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Oxygen	254-260	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	190-193
29978709-5	2018	By further immobilization of the MOFs onto transparent silicon rubber (MOF@SR) to construct O2 film sensors, and real-time monitoring of O2 consumption on MOF@SR over the reaction time, the complete TET2-mediated 5-methylcytosine (5mC) oxidation process were achieved.	Oxygen	92-94	tet methylcytosine dioxygenase 2	Mus musculus	199-203
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Oxygen	254-260	complement C2	Homo sapiens	205-208
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Oxygen	254-260	hemoglobin subunit alpha pseudogene 1	Homo sapiens	285-289
29978709-5	2018	By further immobilization of the MOFs onto transparent silicon rubber (MOF@SR) to construct O2 film sensors, and real-time monitoring of O2 consumption on MOF@SR over the reaction time, the complete TET2-mediated 5-methylcytosine (5mC) oxidation process were achieved.	Oxygen	137-139	tet methylcytosine dioxygenase 2	Mus musculus	199-203
15528549-3	2004	In recombinant S. cerevisiae expressing XYL1, XYL2, and XYL3, mRNA transcript levels for glycolytic, fermentative, and pentose phosphate enzymes did not change significantly on glucose or xylose under aeration or oxygen limitation.	Oxygen	213-219	D-xylulose reductase XYL2	Saccharomyces cerevisiae S288C	46-50
29978709-7	2018	As a result, the Michaelis-Menten constant ( Km) values of TET2 for 5mC and O2 in ascorbic acid-free (AA-) condition were precisely evaluated to be 24 +- 1 and 43.8 +- 0.3 muM, respectively.	Oxygen	76-78	tet methylcytosine dioxygenase 2	Mus musculus	59-63
30044385-7	2018	In summary, our results indicate a role of TKTL1 in the adaptation of tumor cells to oxygen deprivation and in the acquisition of radioresistance.	Oxygen	85-91	transketolase like 1	Homo sapiens	43-48
15450936-5	2004	Total GSH level decreased markedly (50% of control) by 2 h, began to recover at 4 h, returned to control level by 6 h and increased above the control level during 10-24 h. Collectively, these results indicated that overproduced O2*- depletes GSH and triggers induction of xCT, HO-1, iNOS and HO-1 expression in sequence.	Oxygen	228-230	solute carrier family 7 member 11	Homo sapiens	272-275
17018848-1	2007	Erythropoietin (EPO), a 34-kDa glycoprotein, is produced predominantly by peritubular interstitial cells (PIC) in the renal cortex and is physiologically released when ambient oxygen pressure falls.	Oxygen	176-182	erythropoietin	Rattus norvegicus	0-14
17018848-1	2007	Erythropoietin (EPO), a 34-kDa glycoprotein, is produced predominantly by peritubular interstitial cells (PIC) in the renal cortex and is physiologically released when ambient oxygen pressure falls.	Oxygen	176-182	erythropoietin	Rattus norvegicus	16-19
15450936-5	2004	Total GSH level decreased markedly (50% of control) by 2 h, began to recover at 4 h, returned to control level by 6 h and increased above the control level during 10-24 h. Collectively, these results indicated that overproduced O2*- depletes GSH and triggers induction of xCT, HO-1, iNOS and HO-1 expression in sequence.	Oxygen	228-230	heme oxygenase 1	Homo sapiens	277-281
15450936-5	2004	Total GSH level decreased markedly (50% of control) by 2 h, began to recover at 4 h, returned to control level by 6 h and increased above the control level during 10-24 h. Collectively, these results indicated that overproduced O2*- depletes GSH and triggers induction of xCT, HO-1, iNOS and HO-1 expression in sequence.	Oxygen	228-230	inositol-3-phosphate synthase 1	Homo sapiens	283-287
15450936-5	2004	Total GSH level decreased markedly (50% of control) by 2 h, began to recover at 4 h, returned to control level by 6 h and increased above the control level during 10-24 h. Collectively, these results indicated that overproduced O2*- depletes GSH and triggers induction of xCT, HO-1, iNOS and HO-1 expression in sequence.	Oxygen	228-230	heme oxygenase 1	Homo sapiens	292-296
15489080-1	2004	PURPOSE: The purpose of the study presented here was to determine the improvement in image quality of oxygen-enhanced magnetic resonance (MR) subtraction imaging obtained with a centrically reordered inversion recovery half-Fourier single-shot turbo spin-echo (c-IR-HASTE) sequence compared with that obtained with a conventional sequentially reordered inversion recovery single-shot HASTE (s-IR-HASTE) sequence for pulmonary imaging.	Oxygen	102-108	corepressor interacting with RBPJ, CIR1	Homo sapiens	261-265
15489080-3	2004	Oxygen-enhanced MR images were obtained with the coronal two-dimensional (2D) c-IR-HASTE sequence and 2D s-IR-HASTE sequence combined with respiratory triggering.	Oxygen	0-6	corepressor interacting with RBPJ, CIR1	Homo sapiens	78-82
15489080-9	2004	CONCLUSION: Centrically reordered inversion recovery half-Fourier single-shot turbo spin-echo (c-IR-HASTE) sequence enhanced the signal from the lung and improved the image quality of oxygen-enhanced MR subtraction imaging.	Oxygen	184-190	corepressor interacting with RBPJ, CIR1	Homo sapiens	95-99
17038488-6	2007	VEGF secretion rate is determined from the predicted tissue oxygen level through its effect on the hypoxia inducible factor-1alpha transcription factor.	Oxygen	60-66	vascular endothelial growth factor A	Rattus norvegicus	0-4
16870332-6	2007	The dissolved oxygen competed against hydroxyl radical to react with ortho-parachlorohydroxyphenyl radical (ClHP) producing ortho-parachlorophenolperoxyl radical (ClPP) and impeding the generation of 4-chlorocatechol.	Oxygen	14-20	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	163-167
30338145-1	2018	Visible-light optical coherence tomography (vis-OCT) enables retinal oximetry by measuring the oxygen saturation of hemoglobin (sO2) from within individual retinal blood vessels.	Oxygen	95-101	plexin A2	Homo sapiens	48-51
17264037-10	2007	This oxygen species may induce redox-sensitive gene transcription such as HO-1.	Oxygen	5-11	heme oxygenase 1	Homo sapiens	74-78
17968679-5	2007	Constitutive CYP1A1 mRNA was measured by real time PCR in human pulmonary microvascular endothelial cells exposed to hypoxia (1 or 2.5% O2), 25 nM AHR siRNA, 25 nM hypoxia-inducible factor (HIF)-2alpha siRNA, or their combinations.	Oxygen	136-138	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
15297453-1	2004	Human heme oxygenase-1 (hHO-1) catalyzes the O2-dependent oxidation of heme to biliverdin, CO, and free iron.	Oxygen	45-47	heme oxygenase 1	Homo sapiens	6-22
15297453-1	2004	Human heme oxygenase-1 (hHO-1) catalyzes the O2-dependent oxidation of heme to biliverdin, CO, and free iron.	Oxygen	45-47	heme oxygenase 1	Homo sapiens	24-29
29678719-5	2018	Among the signaling pathways that control cellular protective mechanisms against oxygen radical damage is heme oxygenase-1 (HO-1).	Oxygen	81-87	heme oxygenase 1	Homo sapiens	106-122
15466261-1	2004	The hypoxia-inducible factors (HIF) are alpha/beta heterodimeric transcription factors of the basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily and are chiefly responsible for cellular adaptation to oxygen deprivation.	Oxygen	208-214	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	31-34
17598161-4	2007	In addition, this study tested the hypothesis that in vivo exposure to different oxygen (O(2)) concentrations causes a differential activation of G proteins in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus.	Oxygen	81-87	carbonic anhydrase 1	Rattus norvegicus	164-167
29678719-5	2018	Among the signaling pathways that control cellular protective mechanisms against oxygen radical damage is heme oxygenase-1 (HO-1).	Oxygen	81-87	heme oxygenase 1	Homo sapiens	124-128
29988376-6	2018	NK cell degranulation in subsets expressing KIRs and/or NKG2A was assessed at 21 or 0.6% O2.	Oxygen	89-91	killer cell lectin like receptor C1	Homo sapiens	56-61
17177443-10	2006	Theoretical results also identified interactions between the Hb6 and beta-phosphate oxygen of the UDP and a low-barrier hydrogen bond between the nucleophile and the catalytic base D291.	Oxygen	84-90	keratin 86	Homo sapiens	61-64
17172430-0	2006	Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha.	Oxygen	34-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	67-98
15486475-0	2004	Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression.	Oxygen	36-42	presenilin 1	Mus musculus	20-32
15610614-7	2004	Obtained results indicate that the presence of the additional phenol group at C-5 in GAM favours the formation of intramolecular hydrogen bonding of the O...HO type between C2-OH proton and oxygen atom of the amide group.	Oxygen	190-196	complement C5	Homo sapiens	78-81
29988376-7	2018	Activated NKG2A+ NK cell subsets degranulated more vigorously than NKG2A- subsets both at 21 and 0.6% O2.	Oxygen	102-104	killer cell lectin like receptor C1	Homo sapiens	10-15
29921218-15	2018	Further researches must be conducted to elucidate the molecular mechanism underlying LKB1/AMPK response to oxygen supply.	Oxygen	107-113	serine/threonine kinase 11	Rattus norvegicus	85-89
15310824-5	2004	The NADPH-requiring CytP450 would be activated by elevated O2 and reduced CO2 concentrations resulting from mesophyll photosynthesis.	Oxygen	59-61	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	20-27
15310824-6	2004	An increased O2-to-CO2 ratio would limit the Calvin cycle in guard cells, diverting NADPH produced by photosynthetic electron transport to the cytosol where, along with elevated O2, it would activate CytP450.	Oxygen	13-15	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	200-207
16804693-1	2006	Superoxide dismutase (SODs) are metalloenzymes that catalyze the dismutation of the superoxide anion to molecular oxygen and hydrogen peroxide and, thus, form a crucial part of the cellular antioxidant defense mechanism.	Oxygen	114-120	superoxide dismutase [Cu-Zn]	Bombyx mori	0-20
29704621-2	2018	Previously, we reported that mitoNEET is a redox enzyme that catalyzes electron transfer from the reduced flavin mononucleotide (FMNH2) to oxygen or ubiquinone via its unique [2Fe-2S] clusters.	Oxygen	139-145	CDGSH iron sulfur domain 1	Homo sapiens	29-37
17097563-3	2006	Under hypoxia (1% O2), HIF-1alpha was transiently stabilized and primarily mediated acute responses, whereas HIF-2alpha protein gradually accumulated and governed prolonged hypoxic gene activation.	Oxygen	18-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	23-33
15310824-6	2004	An increased O2-to-CO2 ratio would limit the Calvin cycle in guard cells, diverting NADPH produced by photosynthetic electron transport to the cytosol where, along with elevated O2, it would activate CytP450.	Oxygen	20-22	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	200-207
15339940-3	2004	Functionally, myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia.	Oxygen	47-49	myoglobin	Homo sapiens	14-23
15339940-4	2004	Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2.	Oxygen	50-52	myoglobin	Homo sapiens	0-9
15339940-4	2004	Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2.	Oxygen	130-132	myoglobin	Homo sapiens	0-9
15339940-4	2004	Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2.	Oxygen	130-132	myoglobin	Homo sapiens	0-9
15339940-5	2004	The use of gene targeting and other molecular biological techniques has revealed important new insights into the developmental and environmental regulation of myoglobin and provided additional functions for this hemoprotein such as scavenging nitric oxide and reactive O2 species.	Oxygen	269-271	myoglobin	Homo sapiens	159-168
15262216-8	2004	The first demonstration of age-related decreases in Epo expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases, suggesting that age-related decreases in Epo may contribute to degenerative events following age-related decreases in brain flow and oxygen supply.	Oxygen	341-347	erythropoietin	Rattus norvegicus	52-55
17015677-4	2006	These data suggest that HIF-1alpha not only plays a critical role in oxygen homeostasis but also may serve as a negative regulator of T cells.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	24-34
16826568-8	2006	In summary, we demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia.	Oxygen	167-173	protein phosphatase 1 regulatory subunit 8	Homo sapiens	49-54
29704621-5	2018	When the reduced mitoNEET [2Fe-2S] clusters are exposed to air, the [2Fe-2S] clusters are slowly oxidized by oxygen at a rate constant of about 6.0 M-1 s-1.	Oxygen	109-115	CDGSH iron sulfur domain 1	Homo sapiens	17-25
29704621-6	2018	Compared with oxygen, ubiquinone-2 has a much higher activity to oxidize the reduced mitoNEET [2Fe-2S] clusters at a rate constant of about 3.0 x 103 M-1 s-1 under anaerobic conditions.	Oxygen	14-20	CDGSH iron sulfur domain 1	Homo sapiens	85-93
29704621-8	2018	However, when NADH is completely consumed, the reduced mitoNEET [2Fe-2S] clusters are gradually oxidized by oxygen.	Oxygen	108-114	CDGSH iron sulfur domain 1	Homo sapiens	55-63
16971531-0	2006	The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.	Oxygen	86-92	endothelial PAS domain protein 1	Homo sapiens	64-70
15131020-8	2004	The beta(3)-AR agonist stimulated thermogenesis in lean and ob/ob mice, an effect that was much stronger in COOH-pretreated mice, which exhibited lower respiratory quotient, higher oxygen consumption, and marked weight and fat mass loss, compared with mice not pretreated with COOH.	Oxygen	181-187	adrenergic receptor, beta 3	Mus musculus	4-14
29799025-3	2018	Our current study focused on the interaction of HBx with a transcription factor, hypoxia-inducible factor-1alpha (HIF-1alpha), which is stabilized by low O2 condition (hypoxia) and is found to be frequently overexpressed in HCC intra-tumorally due to poor blood perfusion.	Oxygen	154-156	X protein	Hepatitis B virus	48-51
15336911-7	2004	Furthermore, despite the fact that the p38 MAPK pathway was activated less strongly by GM-CSF, the p38 MAPK inhibitor SB203580 reduced GM-CSF-induced O2- production in the neutrophils of the elderly to levels similar to those obtained with PD98059.	Oxygen	150-152	colony stimulating factor 2	Homo sapiens	135-141
16751246-0	2006	Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin.	Oxygen	35-37	myoglobin	Homo sapiens	61-70
29861625-13	2018	Inhibiting the Smoothened receptor using cyclopamine could control retinal neovascularization, providing new ideas and measures for the prevention of oxygen-induced retinal neovascularization.	Oxygen	150-156	smoothened, frizzled class receptor	Mus musculus	15-25
16914311-9	2006	Central to these new renditions is the hypothesis that the appropriate P-450 introduces dioxygen into the precursor yielding either: A, a 20 peroxy sterol species or B, a species oxygenated at both C-17 and C-20 or C, a species oxygenated at both C-20 and C-21.	Oxygen	88-96	cytokine like 1	Homo sapiens	198-202
29032465-5	2018	Evidence of oxygen-independent mechanisms of regulation, transcriptional control of EPAS1/HIF2A and possible cytoplasmic activities of HIF-2alpha has also emerged during recent years.	Oxygen	12-18	endothelial PAS domain protein 1	Homo sapiens	135-145
16814746-7	2006	Expression of Oct4 was inhibited under 8% O(2) condition, but after adipocyte differentiation in normoxic culture and hypoxia-mimicking agents cobalt chloride (CoCl(2)) and deferoxamine mesylate (DFX) treatments, Oct4 was still expressed in MSCs.	Oxygen	42-46	POU class 5 homeobox 1	Homo sapiens	14-18
15132980-7	2004	These findings support a central role for HIF-1alpha in coordinating energy availability and utilization in the heart and have implications for disease states in which cardiac oxygen delivery is impaired.	Oxygen	176-182	hypoxia inducible factor 1, alpha subunit	Mus musculus	42-52
29546425-5	2018	miR-1246 was induced &gt;150-fold during syncytiotrophoblast differentiation in 20% O2, whereas targets-GSK3beta, AXIN2, and JARID2-were significantly decreased.	Oxygen	84-86	microRNA 1246	Homo sapiens	0-8
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	Oxygen	38-40	mitogen-activated protein kinase 7	Homo sapiens	146-150
15178135-1	2004	A mutation in a subunit of complex I of the mitochondrial electron transport chain (gas-1) causes Caenorhabditis elegans to be hypersensitive to volatile anesthetics and oxygen as well as shortening lifespan.	Oxygen	170-176	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	84-89
16909882-3	2006	A training device has been developed that induces hypoxia using mixed gas delivered through an aviator"s oxygen mask.	Oxygen	105-111	ankyrin repeat and KH domain containing 1	Homo sapiens	112-116
16764994-3	2006	Although the sit4 mutant failed to grow on respiratory substrates, in the exponential growth, phase respiration was de-repressed; active respiration was confirmed by measuring oxygen consumption and NADH generation.	Oxygen	176-182	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	13-17
29546425-6	2018	However, when cytotrophoblasts were cultured in 2% O2, miR-1246 and aromatase induction were prevented.	Oxygen	51-53	microRNA 1246	Homo sapiens	55-63
29409830-4	2018	Cerulein administration resulted in activation and stabilization of hypoxia-inducible factor-1alpha (HIF1alpha) in pancreata of oxygen-dependent degradation domain-luciferase HIF1alpha reporter mice.	Oxygen	128-134	hypoxia inducible factor 1, alpha subunit	Mus musculus	68-99
16330260-2	2006	Thus, the objective of our study was to determine if anemic Epo-TAg(h) mice could survive in hypoxia despite low oxygen carrying capacity.	Oxygen	113-119	erythropoietin	Mus musculus	60-63
15128241-1	2004	Highly substituted oxygen heterocycles can be prepared in good yields at room temperature by reacting o-(1-alkynyl)-substituted arene carbonyl compounds with NBS, I(2), ICl, p-O(2)NC(6)H(4)SCl, or PhSeBr and various alcohols or carbon-based nucleophiles.	Oxygen	19-25	nibrin	Homo sapiens	158-161
14693680-8	2004	Because we have previously demonstrated that hypoxia (3% O2) can enhance VSMC proliferation induced by VEGF-A through Flt-1 receptor upregulation, the effects of hypoxia on the response of VSMCs to MCP-1 were investigated.	Oxygen	57-59	vascular endothelial growth factor A	Rattus norvegicus	103-109
15121835-3	2004	In earlier work using genetically manipulated mouse embryo fibroblasts (mEFs), we found a functional relationship among c-jun expression, c-Jun N-terminal phosphorylation, and the presence of hypoxia-inducible factor 1 alpha (HIF-1 alpha), the oxygen-regulated subunit of the HIF-1 transcription factor.	Oxygen	244-250	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-224
15121835-3	2004	In earlier work using genetically manipulated mouse embryo fibroblasts (mEFs), we found a functional relationship among c-jun expression, c-Jun N-terminal phosphorylation, and the presence of hypoxia-inducible factor 1 alpha (HIF-1 alpha), the oxygen-regulated subunit of the HIF-1 transcription factor.	Oxygen	244-250	hypoxia inducible factor 1, alpha subunit	Mus musculus	226-237
16721869-3	2006	In 1, the Cd1, Cd3, and Cd4 atoms are all pentacoordinate, while the Cd2 atom is coordinated by four oxygen atoms from three phosphonate ligands and two nitrogen atoms from the chelating phen in a distorted octahedral geometry.	Oxygen	101-107	CD2 molecule	Homo sapiens	69-72
16829576-1	2006	Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death.	Oxygen	99-105	monoamine oxidase A	Homo sapiens	0-19
16829576-1	2006	Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death.	Oxygen	99-105	monoamine oxidase A	Homo sapiens	21-26
29409830-4	2018	Cerulein administration resulted in activation and stabilization of hypoxia-inducible factor-1alpha (HIF1alpha) in pancreata of oxygen-dependent degradation domain-luciferase HIF1alpha reporter mice.	Oxygen	128-134	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-110
15194408-9	2004	VEGF enhanced oxygen levels at the transplant site.	Oxygen	14-20	vascular endothelial growth factor A	Rattus norvegicus	0-4
29409830-4	2018	Cerulein administration resulted in activation and stabilization of hypoxia-inducible factor-1alpha (HIF1alpha) in pancreata of oxygen-dependent degradation domain-luciferase HIF1alpha reporter mice.	Oxygen	128-134	hypoxia inducible factor 1, alpha subunit	Mus musculus	175-184
16849552-3	2006	Hypoxia (1% O2) strongly induced Egr-1 mRNA within 1 hour and led to nuclear localization of Egr-1 protein.	Oxygen	12-14	early growth response 1	Homo sapiens	33-38
32254458-0	2018	Core-shell protein clusters comprising haemoglobin and recombinant feline serum albumin as an artificial O2 carrier for cats.	Oxygen	105-107	albumin	Felis catus	74-87
16849552-3	2006	Hypoxia (1% O2) strongly induced Egr-1 mRNA within 1 hour and led to nuclear localization of Egr-1 protein.	Oxygen	12-14	early growth response 1	Homo sapiens	93-98
16849552-7	2006	Forced overexpression of Egr-1 but not Sp1 by cDNA transfection caused up-regulation of tissue factor in glioma cells under normoxia (21% O2), whereas siRNA directed at Egr-1 strongly attenuated hypoxia-induced tissue factor expression.	Oxygen	138-140	early growth response 1	Homo sapiens	25-30
14752117-8	2004	The C1" of the modeled donor mannose is within hydrogen-bonding distance of both the hydroxyl of Tyr(220) and the O2 of the acceptor mannose.	Oxygen	114-116	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	4-7
14726520-9	2004	Pentamidine binds QacR in a novel fashion whereby one of its benzamidine groups interacts with residue Glu-63, and the other is neutralized by carbonyl and side chain oxygen atoms.	Oxygen	167-173	QacR	Staphylococcus aureus	18-22
29540477-5	2018	The CHCHD10 gene was maximally transcribed in cultured cells at 8% oxygen, unlike MNRR1, which was maximally expressed at 4%, suggesting a fine-tuned oxygen-sensing system that adapts to the varying oxygen concentrations in the human body under physiological conditions.	Oxygen	67-73	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	4-11
14726529-3	2004	In addition, it became apparent that Hsp90 protects HIF-1alpha from oxygen-independent degradation.	Oxygen	68-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-42
16636360-0	2006	Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	63-73
16702992-12	2006	Chol-but SLN inhibited O2-* production and myeloperoxidase release by PMNs evoked by FMLP, in a dose-dependent, but not time-dependent, manner and were more active than sodium butyrate.	Oxygen	23-25	sarcolipin	Homo sapiens	9-12
15039298-0	2004	Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.	Oxygen	20-26	myeloperoxidase	Rattus norvegicus	87-102
29540477-5	2018	The CHCHD10 gene was maximally transcribed in cultured cells at 8% oxygen, unlike MNRR1, which was maximally expressed at 4%, suggesting a fine-tuned oxygen-sensing system that adapts to the varying oxygen concentrations in the human body under physiological conditions.	Oxygen	150-156	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	4-11
29540477-5	2018	The CHCHD10 gene was maximally transcribed in cultured cells at 8% oxygen, unlike MNRR1, which was maximally expressed at 4%, suggesting a fine-tuned oxygen-sensing system that adapts to the varying oxygen concentrations in the human body under physiological conditions.	Oxygen	150-156	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	4-11
29540477-6	2018	We show that nuclear CHCHD10 protein down-regulates the expression of genes harboring the oxygen-responsive element (ORE) in their promoters by interacting with and augmenting the activity of the largely uncharacterized transcriptional repressor CXXC finger protein 5 (CXXC5).	Oxygen	90-96	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	21-28
29740323-0	2018	The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro.	Oxygen	111-117	carbonic anhydrase 1	Rattus norvegicus	149-152
16840407-7	2006	In this series of 25 patients, the largest reported to date, administration of GM-CSF improved oxygenation as assessed by a 10 mm Hg decrease in alveolar-arterial oxygen gradient, as well as improvement in other clinical and quality of life parameters in 12 of 25 patients (48%) with moderate symptomatic disease who completed the trial.	Oxygen	95-101	colony stimulating factor 2	Homo sapiens	79-85
16292251-5	2006	Astrocytes overexpressing Hsp70-WT, -K71E, or -381-640 were all significantly protected from 4 h combined oxygen-glucose deprivation and 24 h reperfusion when assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay or propidium iodide staining and cell counting (P &lt; 0.05).	Oxygen	106-112	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	26-31
29153949-0	2018	A novel label-free electrochemical immunosensor for ultra-sensitively detecting prostate specific antigen based on the enhanced catalytic currents of oxygen reduction catalyzed by core-shell Au@Pt nanocrystals.	Oxygen	150-156	kallikrein related peptidase 3	Homo sapiens	80-105
16513203-0	2006	Hyperbaric oxygen induces vascular endothelial growth factor and reduces liver injury in regenerating rat liver after partial hepatectomy.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	26-60
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	82-88	vascular endothelial growth factor A	Rattus norvegicus	190-194
16756681-10	2006	The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction.	Oxygen	107-113	plasminogen activator, urokinase receptor	Homo sapiens	47-51
16460831-1	2006	BACKGROUND/AIMS: The antimicrobial peptide hepcidin is generated in the liver and released into the circulation in response to iron, oxygen and inflammatory signals.	Oxygen	133-139	hepcidin antimicrobial peptide	Homo sapiens	43-51
29849885-1	2018	High altitude training is one of the effective strategies for improving aerobic exercise performance at sea level via altitude acclimatization, thereby improving oxygen transport and/or utilization.	Oxygen	162-168	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Oxygen	145-151	potassium voltage-gated channel subfamily H member 2	Homo sapiens	155-159
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Oxygen	145-151	potassium voltage-gated channel subfamily H member 2	Homo sapiens	272-276
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Oxygen	145-151	potassium voltage-gated channel subfamily H member 2	Homo sapiens	272-276
29955578-5	2018	Since high-altitude may raise PVR in response to reduction in the partial pressure of oxygen, we conclude that the long-term outcome of increased altitude on Fontan hemodynamics can lead to the shunt of teeth flora and consequently leading to severe infections.	Oxygen	86-92	PVR cell adhesion molecule	Homo sapiens	30-33
16331674-1	2006	Low oxygen tension is thought to be an integral component of the human mesenchymal stem cell (hMSC) native bone marrow microenvironment.	Oxygen	4-10	musculin	Homo sapiens	94-98
16331674-8	2006	Further studies are required to determine how variations in cellular characteristics and ECM expression impact on the physiological properties of the engineered tissue, yet these results strongly indicate that oxygen tension is a key parameter that influences the in vitro characteristics of hMSC and their development into tissues.	Oxygen	210-216	multimerin 1	Homo sapiens	89-92
16331674-8	2006	Further studies are required to determine how variations in cellular characteristics and ECM expression impact on the physiological properties of the engineered tissue, yet these results strongly indicate that oxygen tension is a key parameter that influences the in vitro characteristics of hMSC and their development into tissues.	Oxygen	210-216	musculin	Homo sapiens	292-296
29279366-0	2018	Evaluation of Safety and Cost of an Open-Design Oxygen Mask in a Large Community Hospital.	Oxygen	48-54	ankyrin repeat and KH domain containing 1	Homo sapiens	55-59
16568184-3	2006	X-Ray structural (9-), DFT and EPR spectroscopic studies are consistent with the unpaired electron of 9- and 10- localised primarily on the Rh(II) centre of the [RhPd]4+ core, which is susceptible to oxygen coordination at low temperature to give Rh(III)-bound superoxide.	Oxygen	200-206	Rh blood group D antigen	Homo sapiens	140-146
29279366-2	2018	We hoped to eliminate this safety concern through adoption of an open-design oxygen mask.	Oxygen	77-83	ankyrin repeat and KH domain containing 1	Homo sapiens	84-88
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	Oxygen	17-25	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
29279366-4	2018	Finally, by standardizing to one mask, goals were to reduce the cost of oxygen delivery.	Oxygen	72-78	ankyrin repeat and KH domain containing 1	Homo sapiens	33-37
16562956-9	2006	Observations concerning the reactivity of the dioxygen adducts 2H and 3(NMe2) toward external substrates are also presented.	Oxygen	46-54	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	72-76
29279366-5	2018	METHODS: We conducted a retrospective analysis, 12 months before and 12 months after implementation of the open-design oxygen mask.	Oxygen	119-125	ankyrin repeat and KH domain containing 1	Homo sapiens	126-130
29279366-14	2018	The net savings from open-design oxygen mask conversion was $23,487 annual and corrected for increased patient population.	Oxygen	33-39	ankyrin repeat and KH domain containing 1	Homo sapiens	40-44
29279366-15	2018	Oxygen consumption and supply cost per patient day resulted in $1.19 per patient day pre-implementation and $0.95 after implementation of the open-design oxygen mask (P = .003).	Oxygen	0-6	ankyrin repeat and KH domain containing 1	Homo sapiens	161-165
29279366-15	2018	Oxygen consumption and supply cost per patient day resulted in $1.19 per patient day pre-implementation and $0.95 after implementation of the open-design oxygen mask (P = .003).	Oxygen	154-160	ankyrin repeat and KH domain containing 1	Homo sapiens	161-165
16254683-4	2006	The observed increased expression of phospholipids, mannoproteins, and cold shock proteins (e.g., TIP1) is consistent with membrane maintenance and increased permeability of the cell wall at 4 degrees C. The induction of heat shock proteins and glutathione at 4 degrees C may be required for revitalization of enzyme activity, and for detoxification of active oxygen species, respectively.	Oxygen	360-366	putative lipase	Saccharomyces cerevisiae S288C	98-102
29279366-16	2018	CONCLUSIONS: The open-design oxygen mask may be a safe and less costly alternative to traditional oxygen delivery devices.	Oxygen	29-35	ankyrin repeat and KH domain containing 1	Homo sapiens	36-40
29279366-16	2018	CONCLUSIONS: The open-design oxygen mask may be a safe and less costly alternative to traditional oxygen delivery devices.	Oxygen	98-104	ankyrin repeat and KH domain containing 1	Homo sapiens	36-40
29118013-7	2018	Diminishing glycolytic flux by knockdown of the first and final enzyme of glycolysis, i.e., hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption.	Oxygen	198-204	pyruvate kinase M1/2	Homo sapiens	115-132
16507596-2	2006	We show that prooxidants (menadione, hydrogen peroxide) as well as chemical (CoCl2) and physiological (1% O2) hypoxia increased CT-1 as well as HIF-1alpha protein and mRNA expression in embryoid bodies, indicating that CT-1 expression is regulated by reactive oxygen species (ROS) and hypoxia.	Oxygen	106-108	hypoxia inducible factor 1, alpha subunit	Mus musculus	144-154
16492983-2	2006	We hypothesized that resuscitation from HI with 100% O2 would result in greater Egr-1 expression, ROS, and cell death (CD) in the brains of newborn piglets than 21% O2.	Oxygen	53-55	early growth response 1	Homo sapiens	80-85
16403522-5	2006	The mechanism by which L35 reduces oxygen affinity is discussed, in relation to spectroscopic studies of effector binding.	Oxygen	35-41	ribosomal protein L35	Homo sapiens	23-26
29259012-0	2018	FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.	Oxygen	10-16	euchromatic histone lysine methyltransferase 1	Homo sapiens	50-53
16465194-7	2006	We propose that TKTL1 upregulation in tumours leads to enhanced, oxygen-independent glucose usage and a lactate-based matrix degradation.	Oxygen	65-71	transketolase like 1	Homo sapiens	16-21
29259012-8	2018	It also implies that the FIH-G9a/GLP pathway could be a potential target for inhibiting hypoxia-induced cancer metastasis.Significance: These findings deepen understanding of oxygen-dependent gene regulation and cancer metastasis in response to hypoxia.	Oxygen	175-181	euchromatic histone lysine methyltransferase 1	Homo sapiens	33-36
29315429-7	2018	Hypoxia with &lt;10% O2 significantly decreased mRNA expression of LAT1 in both cell lines, indicating that reduced uptake of 10B-BPA in glioblastoma in hypoxic conditions may be due to reduced expression of this important transporter protein.	Oxygen	21-23	solute carrier family 7 member 5	Homo sapiens	67-71
16483933-8	2006	Together, eIF2alpha, eEF2, and mTOR inhibition represent important HIF-independent mechanisms of energy conservation that promote survival under low O2 conditions.	Oxygen	149-151	eukaryotic translation elongation factor 2	Homo sapiens	21-25
29065215-7	2018	Gene expression experiments showed that, apart from the conventional nitrogen catabolic repression mechanism that is operating in aerobiosis, there seems to be an oxygen-independent mechanism acting to overexpress key genes like GAP1, GDH1, GDH2 and GLT1 to ensure adequate anaerobic growth even in the presence of non-preferential nitrogen source.	Oxygen	163-169	glutamate dehydrogenase (NADP(+)) GDH1	Saccharomyces cerevisiae S288C	235-239
16455272-1	2006	Hyphal tip-growing organisms have a high density of tip-localized mitochondria which maintain a membrane potential based on Rhodamine 123 fluorescence, but do not produce ATP based on the absence of significant oxygen consumption.	Oxygen	211-217	TOR signaling pathway regulator	Homo sapiens	7-10
16455272-1	2006	Hyphal tip-growing organisms have a high density of tip-localized mitochondria which maintain a membrane potential based on Rhodamine 123 fluorescence, but do not produce ATP based on the absence of significant oxygen consumption.	Oxygen	211-217	TOR signaling pathway regulator	Homo sapiens	52-55
29065215-7	2018	Gene expression experiments showed that, apart from the conventional nitrogen catabolic repression mechanism that is operating in aerobiosis, there seems to be an oxygen-independent mechanism acting to overexpress key genes like GAP1, GDH1, GDH2 and GLT1 to ensure adequate anaerobic growth even in the presence of non-preferential nitrogen source.	Oxygen	163-169	glutamate dehydrogenase (NAD(+))	Saccharomyces cerevisiae S288C	241-245
16507746-4	2006	Kaelin and colleagues have created a mouse line that expresses the oxygen-dependent degradation domain (ODD) of hypoxia-induced factor-1alpha (HIF-1alpha) fused to the common firefly luciferase gene, under the control of a promoter that ensures organism-wide expression.	Oxygen	67-73	hypoxia inducible factor 1, alpha subunit	Mus musculus	143-153
29472618-3	2018	Inflamed tissues are typically characterized by low levels of oxygen, a microenvironment that triggers the hypoxia-inducible transcription factor 1alpha (HIF-1alpha).	Oxygen	62-68	hypoxia inducible factor 1, alpha subunit	Mus musculus	154-164
29443922-10	2018	Moreover, oxygen disturbances and the activation of a hypoxia-induced factor during or after exercise may stimulate a reduction of hepcidin expression.	Oxygen	10-16	hepcidin antimicrobial peptide	Homo sapiens	131-139
16439573-9	2006	Our findings suggest that the molecular basis for the differential electrophysiological characteristics including opposing response to oxygen in the DA and the PA are partially due to diversity in expression of Kv1.5 and Kvbeta1.2 subunits.	Oxygen	135-141	potassium voltage-gated channel subfamily A regulatory beta subunit 1	Homo sapiens	221-228
16405343-3	2006	In the first step, a proton from the hydroxyl oxygen on the second carbon of 2HM, or from the third carbon of 2o4hex, is abstracted by Pro-1.	Oxygen	46-52	lamin A/C	Homo sapiens	135-140
29378948-1	2018	The oncoprotein c-Myc plays an important role in regulating glycolysis under normoxia; yet, in cancer cells, HIF1alpha, which is essential for driving glycolysis under hypoxia, is often up-regulated even in the presence of oxygen.	Oxygen	223-229	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	16-21
29358393-6	2018	O2 consumption rates (OCRs) and expression of genes involved in both fatty acid synthesis and fatty acid oxidation were increased in WAT-SQ of A3-/-A8-/- mice, but not in their epididymal or brown adipose tissue (BAT).	Oxygen	0-2	brain protein 8	Mus musculus	143-158
16394004-7	2006	Using Immunogold electron microscopy, PGRP-S was localized to the dense/large granules of naive neutrophils, which contain the oxygen-independent bactericidal proteins of these cells, and to the neutrophil phagolysosome.	Oxygen	127-133	peptidoglycan recognition protein 1	Bos taurus	38-44
15047138-14	2004	CONCLUSIONS: During gradual hypoxia, beta-ATP decreased, P(i) increased, and pH(i) decreased in the rat liver, depending on the oxygen concentration.	Oxygen	128-134	glucose-6-phosphate isomerase	Rattus norvegicus	77-82
28956099-6	2018	We used a Seahorse extracellular flux analyzer to measure oxygen consumption rate (OCR), a proxy for mitochondrial metabolism, in cultured INS-1 832/13 beta cells exposed to iAsIII, MAsIII, or DMAsIII and stimulated with either glucose or pyruvate, a final product of glycolysis and a substrate for the Krebs cycle.	Oxygen	58-64	insulin 1	Rattus norvegicus	139-144
16392856-3	2006	Water molecules were included in the cluster to investigate the influence of explicit solvation on proton-transfer reactions and on the energy associated with hydroxylating the bridging oxygen atom (Obr).	Oxygen	186-192	leptin receptor	Homo sapiens	199-202
29618303-0	2018	Myoglobin: Oxygen Depot or Oxygen Transporter to Mitochondria?	Oxygen	11-17	myoglobin	Homo sapiens	0-9
17089889-4	2006	Specifically, we tested whether the hypoxic response depends on oxygen sensing via the alpha-subunit of hypoxia-inducible factor-1 (HIF-1 alpha).	Oxygen	64-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	132-143
15030229-2	2004	In contrast, the mildly proteolyzed myoglobin had a strongly enhanced prooxidative effect on lipid oxidation in an oil in water methyl linoleate emulsion compared to native metmyoglobin, as evidenced by rates of oxygen depletion.	Oxygen	212-218	myoglobin	Homo sapiens	36-45
29180353-5	2018	Inhibition of the Clec16a pathway by the chemotherapeutic lenalidomide, a selective ubiquitin ligase inhibitor associated with new-onset diabetes, impairs beta-cell mitophagy, oxygen consumption, and insulin secretion.	Oxygen	176-182	C-type lectin domain containing 16A	Homo sapiens	18-25
15012137-1	2004	The cytosolic C-terminal domain of the membrane copper transporter Ctr1 from the yeast Saccharomyces cerevisiae, Ctr1c, was expressed in E. coli as an oxygen-sensitive soluble protein with no significant secondary structure.	Oxygen	151-157	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	67-71
15016076-2	2004	The gene for amyloid precursor protein (APP), known to be involved in AD pathology, resides on chromosome 21 along with the gene for Cu/Zn superoxide dismutase (SOD1), a key enzyme in the metabolism of oxygen free radicals.	Oxygen	202-208	amyloid beta (A4) precursor protein	Mus musculus	13-38
14711902-7	2004	As oxygen concentration decreased, neuronal survival also decreased, which could be reversed by IGF-I, especially at the lowest oxygen concentration.	Oxygen	3-9	insulin-like growth factor 1	Rattus norvegicus	96-101
16100289-5	2006	TG mice had less DNA damage than 95% O2-exposed WT mice at P3, measured by TdT-mediated dUTP nick end labeling (P &lt; 0.05).	Oxygen	37-39	deoxynucleotidyltransferase, terminal	Mus musculus	75-78
16100289-7	2006	95% O2 impaired apical expression of type I cell alpha protein (T1alpha) in WT but not in TG mice at P3 and increased T1alpha in WT and TG mice at P7.	Oxygen	4-6	podoplanin	Mus musculus	64-71
16100289-7	2006	95% O2 impaired apical expression of type I cell alpha protein (T1alpha) in WT but not in TG mice at P3 and increased T1alpha in WT and TG mice at P7.	Oxygen	4-6	podoplanin	Mus musculus	118-125
16100289-8	2006	Reducing the 95% O2-induced impairment of epithelial proliferation at a critical window of lung development was associated with protection against DNA damage and preservation of apical T1alpha expression at P3.	Oxygen	17-19	podoplanin	Mus musculus	185-192
16023192-10	2006	The study suggests that ELP can promote chondrogenesis for hADAS cells in the absence of exogenous TGF-beta1 and dexamethasone, especially under low oxygen tension conditions.	Oxygen	149-155	nuclear receptor subfamily 5 group A member 1	Homo sapiens	24-27
14711902-7	2004	As oxygen concentration decreased, neuronal survival also decreased, which could be reversed by IGF-I, especially at the lowest oxygen concentration.	Oxygen	128-134	insulin-like growth factor 1	Rattus norvegicus	96-101
29129819-8	2018	The oxygen consumption and energy expenditure in HFD-fed alpha7nAChR-/- mice were significantly lower than that in HFD-fed WT mice.	Oxygen	4-10	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	57-71
14765248-0	2004	Co2+-exchanged faujasite zeolites as efficient heterogeneous catalysts for epoxidation of styrene with molecular oxygen.	Oxygen	113-119	complement C2	Homo sapiens	0-3
16083310-14	2006	RA treatment might be beneficial in preventing neovascularization resulting from oxygen-induced retinopathy by downregulation of VEGF expression.	Oxygen	81-87	vascular endothelial growth factor A	Rattus norvegicus	129-133
16557496-3	2006	The experimental data demonstrated that the nitrogen bridge and the coordinated oxygen atom on the nitrogen bridge in the alkaloid compounds were the active sites in the MS2 fragmentations.	Oxygen	80-86	MS2	Homo sapiens	170-173
14765248-1	2004	Co2+-exchanged faujasite zeolites can efficiently catalyze the epoxidation of styrene with molecular oxygen, and the Co2+ ions located in supercages are suggested to account for the activation of O2 for the epoxidation of styrene.	Oxygen	101-107	complement C2	Homo sapiens	0-3
29354815-2	2018	CoP nanoparticles anchored on N,P-dual-doped mesoporous graphene-like carbon (CoP@NPMG) acts as an outstanding bifunctional electrocatalyst for both the hydrogen evolution reaction and the oxygen evolution reaction over a wide pH range.	Oxygen	189-195	caspase recruitment domain family member 16	Homo sapiens	0-3
14765248-1	2004	Co2+-exchanged faujasite zeolites can efficiently catalyze the epoxidation of styrene with molecular oxygen, and the Co2+ ions located in supercages are suggested to account for the activation of O2 for the epoxidation of styrene.	Oxygen	196-198	complement C2	Homo sapiens	0-3
14765248-1	2004	Co2+-exchanged faujasite zeolites can efficiently catalyze the epoxidation of styrene with molecular oxygen, and the Co2+ ions located in supercages are suggested to account for the activation of O2 for the epoxidation of styrene.	Oxygen	196-198	complement C2	Homo sapiens	117-120
16375389-14	2005	Since LaCl3, being the most acidic phase, is not active for the destructive adsorption of CCl4, basic oxygen atoms, however, remain needed to stabilize the reaction intermediate CCl3 as La-O-CCl3.	Oxygen	102-108	C-C motif chemokine ligand 3	Homo sapiens	178-182
29354815-2	2018	CoP nanoparticles anchored on N,P-dual-doped mesoporous graphene-like carbon (CoP@NPMG) acts as an outstanding bifunctional electrocatalyst for both the hydrogen evolution reaction and the oxygen evolution reaction over a wide pH range.	Oxygen	189-195	caspase recruitment domain family member 16	Homo sapiens	78-81
16375389-14	2005	Since LaCl3, being the most acidic phase, is not active for the destructive adsorption of CCl4, basic oxygen atoms, however, remain needed to stabilize the reaction intermediate CCl3 as La-O-CCl3.	Oxygen	102-108	C-C motif chemokine ligand 3	Homo sapiens	191-195
14970030-0	2004	Paramagnetic effect of supplemental oxygen on CSF hyperintensity on fluid-attenuated inversion recovery MR images.	Oxygen	36-42	colony stimulating factor 2	Homo sapiens	46-49
29194945-4	2018	The resulting homologous Co3 O4 and CoP NSs display outstanding catalytic activity in alkaline media toward the oxygen evolution reaction and the hydrogen evolution reaction, respectively, ascribed to the richly exposed active sites, and the expedited electrolyte/ion transmission path.	Oxygen	112-118	caspase recruitment domain family member 16	Homo sapiens	36-39
14970030-1	2004	BACKGROUND AND PURPOSE: Oxygen has a known paramagnetic effect and increases CSF signal intensity on fluid-attenuated inversion recovery (FLAIR) MR images.	Oxygen	24-30	colony stimulating factor 2	Homo sapiens	77-80
14970030-2	2004	The purposes of this study were to investigate the effect of supplemental oxygen on CSF signal intensity and the arterial partial pressure of oxygen and to determine the possible synergistic effect of oxygen and albumin on T1 shortening effect in vitro.	Oxygen	74-80	colony stimulating factor 2	Homo sapiens	84-87
14970030-8	2004	The CSF hyperintensity was observed immediately after the initiation of supplemental oxygen and remained stable during the oxygen administration.	Oxygen	85-91	colony stimulating factor 2	Homo sapiens	4-7
14970030-8	2004	The CSF hyperintensity was observed immediately after the initiation of supplemental oxygen and remained stable during the oxygen administration.	Oxygen	123-129	colony stimulating factor 2	Homo sapiens	4-7
14970030-12	2004	CONCLUSION: Inhalation of increased levels of oxygen led to readily detectable CSF hyperintensity on FLAIR images of healthy volunteers.	Oxygen	46-52	colony stimulating factor 2	Homo sapiens	79-82
16310443-9	2005	Systemic oxygen saturation correlated positively with the levels of anticoagulants (protein C, protein S, antithrombin III) and procoagulants (factors II, V, VII, and X) (all with p&lt;0.05, r=0.33 to 0.61).	Oxygen	9-15	serpin family C member 1	Homo sapiens	106-122
29251416-4	2018	The scanning transmission electron microscopy - annular bright field (STEM-ABF) image successfully confirms the formation of oxygen vacancies in Mnx Niy Znz CO3 , which is beneficial to improve the electrical conductivity.	Oxygen	125-131	keratin 86	Homo sapiens	145-148
16166214-9	2005	Together, these results support the concept that iron, radical oxygen species, and the HIF-2 and -3 as well as the PHD pathways play important roles in mediating effects of hypoxia on IGFBP-1 gene expression in the liver.	Oxygen	63-69	insulin-like growth factor binding protein 1	Rattus norvegicus	184-191
14730659-8	2004	Maximal TA concentrations of MCP-1, MCP-2, MCP-3, MIP-1alpha, and MIP-1beta were significantly higher in infants who were oxygen-dependent at 28 postnatal days compared to infant who were not.	Oxygen	122-128	C-C motif chemokine ligand 4	Homo sapiens	66-75
14730659-9	2004	Similarly, maximal TA MCP-1, MCP-2, and MCP-3 but not MIP-1alpha and MIP-1beta concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks of postconceptional age (PCA) than those who were not oxygen-dependent at 36 weeks PCA.	Oxygen	140-146	C-C motif chemokine ligand 2	Homo sapiens	22-27
14594809-1	2004	The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration.	Oxygen	313-319	zinc finger and BTB domain containing 18	Homo sapiens	4-8
16388451-5	2005	The important role of VEGF and its regulation depending on oxygen pressure suggest a strong connection between this growth factor and the delay phenomenon.	Oxygen	59-65	vascular endothelial growth factor A	Rattus norvegicus	22-26
16311326-3	2005	Sea level mirrors oxygen isotope variations, reflecting ice-volume change on the 10(4)- to 10(6)-year scale, but a link between oxygen isotope and sea level on the 10(7)-year scale must be due to temperature changes that we attribute to tectonically controlled carbon dioxide variations.	Oxygen	18-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
14718443-13	2004	G-CSF in serum and IL-8 in BALF correlated negatively with PaO(2)/fraction of inspired oxygen (FIO(2)) ratio.	Oxygen	87-93	colony stimulating factor 3	Homo sapiens	0-5
29386650-1	2018	Oxygen-induced retinopathy (OIR) upregulates Muller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP).	Oxygen	0-6	vascular endothelial growth factor A	Rattus norvegicus	57-93
15471342-1	2004	We have observed coherent oscillations of the heme protein myoglobin (Mb) following femtosecond laser excitation and photodissociation of the CO, O2, and NO bound ligands.	Oxygen	146-148	myoglobin	Homo sapiens	59-68
15471342-1	2004	We have observed coherent oscillations of the heme protein myoglobin (Mb) following femtosecond laser excitation and photodissociation of the CO, O2, and NO bound ligands.	Oxygen	146-148	myoglobin	Homo sapiens	70-72
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-98
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	endothelial PAS domain protein 1	Mus musculus	103-113
16279779-3	2005	Pro-1 was discovered to form a bifurcated hydrogen bond between its protonated nitrogen and carboxylate oxygens of E-ligands and Tyr-36.	Oxygen	104-111	lamin A/C	Homo sapiens	0-5
29386650-1	2018	Oxygen-induced retinopathy (OIR) upregulates Muller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP).	Oxygen	0-6	vascular endothelial growth factor A	Rattus norvegicus	95-100
29390818-2	2018	Different positive and negative linear pressure coefficients have been calibrated for the emission lines and related to pressure-induced changes in the interactions between those Nd3+ ions and their twelve oxygen ligands at the yttrium site.	Oxygen	206-212	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	179-182
16246080-2	2005	For its enzymatic activity, Erg1p requires molecular oxygen, NAD(P)H and FAD.	Oxygen	53-59	squalene monooxygenase	Saccharomyces cerevisiae S288C	28-33
14676265-3	2004	An unexpected and severe increase of PVR was observed, rising from 392 dynes x s x cm(-5) with oxygen to a maximum of 1192 dynes x s x cm(-5) with oxygen and iloprost.	Oxygen	95-101	PVR cell adhesion molecule	Homo sapiens	37-40
14676265-3	2004	An unexpected and severe increase of PVR was observed, rising from 392 dynes x s x cm(-5) with oxygen to a maximum of 1192 dynes x s x cm(-5) with oxygen and iloprost.	Oxygen	147-153	PVR cell adhesion molecule	Homo sapiens	37-40
28822229-9	2018	The activation of the Wnt/beta-catenin pathway induces, via the Wnt target genes c-Myc and cyclin D1 or via HIF-1alpha, gene transactivation encoding aerobic glycolysis enzymes, such as glucose transporter, hexokinase 2, pyruvate kinase M2, pyruvate dehydrogenase kinase 1 and lactate dehydrogenase-A, leading to lactate production, as the primary alternative of ATP, at all oxygen levels, even in normoxic conditions.	Oxygen	375-381	catenin beta 1	Homo sapiens	26-38
14525961-4	2004	Here, we provide evidence that the process is oxygen-independent by inference related to the release of primary granules and is regulated by cathepsin G activity.	Oxygen	46-52	cathepsin G	Homo sapiens	141-152
16214038-3	2005	The objective of this work was to analyze the role of eNOS in the modulation of oxygen supply to the tissues and in adaptation to maintain oxygenation uncompromised.	Oxygen	80-86	nitric oxide synthase 3, endothelial cell	Mus musculus	54-58
16214038-9	2005	The eNOS(-/-) animals delivered less oxygen to the microcirculation and released more oxygen to the tissue; both differences were statistically significant compared to wild type.	Oxygen	37-43	nitric oxide synthase 3, endothelial cell	Mus musculus	4-8
16214038-9	2005	The eNOS(-/-) animals delivered less oxygen to the microcirculation and released more oxygen to the tissue; both differences were statistically significant compared to wild type.	Oxygen	86-92	nitric oxide synthase 3, endothelial cell	Mus musculus	4-8
16214038-10	2005	The arteriolar vessel wall oxygen gradient, a measure of vascular smooth muscle cells and endothelial cell wall oxygen consumption, was significantly lower for eNOS(-/-) than for wild type, suggesting that the inhibition of eNOS is an antianoxia (oxygen sparing) mechanism.	Oxygen	27-33	nitric oxide synthase 3, endothelial cell	Mus musculus	160-164
28822229-9	2018	The activation of the Wnt/beta-catenin pathway induces, via the Wnt target genes c-Myc and cyclin D1 or via HIF-1alpha, gene transactivation encoding aerobic glycolysis enzymes, such as glucose transporter, hexokinase 2, pyruvate kinase M2, pyruvate dehydrogenase kinase 1 and lactate dehydrogenase-A, leading to lactate production, as the primary alternative of ATP, at all oxygen levels, even in normoxic conditions.	Oxygen	375-381	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	81-86
29352221-3	2018	METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism.	Oxygen	52-58	electron transferring flavoprotein, beta polypeptide	Mus musculus	32-36
16220203-6	2005	The results are as follows: (1) The activity of active PDH (PDHa) was slightly higher in hypertrophic cardiomyocytes than that in normal cardiomyocytes, but the activity of CPT-1 was significantly lower in hypertrophic cardiomyoctes than that in normal cardiomyocytes.Compared with the hypertrophic cardiomyocytes cultured with normal oxygen concentration, the activities of PDHa and CPT-1 were decreased significantly after hypoxia for 8 h, and the activity of PDHa were decreased further after reoxygenation for 4 h, but the activity of CPT-1 recovered quickly after reoxygenation.	Oxygen	335-341	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	55-58
16220203-6	2005	The results are as follows: (1) The activity of active PDH (PDHa) was slightly higher in hypertrophic cardiomyocytes than that in normal cardiomyocytes, but the activity of CPT-1 was significantly lower in hypertrophic cardiomyoctes than that in normal cardiomyocytes.Compared with the hypertrophic cardiomyocytes cultured with normal oxygen concentration, the activities of PDHa and CPT-1 were decreased significantly after hypoxia for 8 h, and the activity of PDHa were decreased further after reoxygenation for 4 h, but the activity of CPT-1 recovered quickly after reoxygenation.	Oxygen	335-341	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	60-64
22436499-7	2005	RESULTS: : The arterial partial pressure of oxygen (PaO2) on FiO2 1.0 decreased from 59.5 +- 11.5 kPa and 55.7 +- 12.2 kPa at TP1 to 39.5 +- 16 kPa and 39.7 +- 13 kPa at TP2 in groups A and B, respectively (P &lt; 0.001), with no significant difference between groups.	Oxygen	44-50	transition protein 1	Homo sapiens	126-129
22436499-7	2005	RESULTS: : The arterial partial pressure of oxygen (PaO2) on FiO2 1.0 decreased from 59.5 +- 11.5 kPa and 55.7 +- 12.2 kPa at TP1 to 39.5 +- 16 kPa and 39.7 +- 13 kPa at TP2 in groups A and B, respectively (P &lt; 0.001), with no significant difference between groups.	Oxygen	44-50	transition protein 2	Homo sapiens	170-173
16181422-0	2005	Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation.	Oxygen	103-109	poly (ADP-ribose) polymerase 1	Rattus norvegicus	36-65
14512429-1	2003	Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity.	Oxygen	9-15	Hap1p	Saccharomyces cerevisiae S288C	73-77
14512429-7	2003	We also found that Hap1 activity exhibits the same oxygen dose-response curves as Hap1-dependent aerobic genes and that these dose-response curves have a sharp break at approximately 1 microM O2.	Oxygen	51-57	Hap1p	Saccharomyces cerevisiae S288C	19-23
14512429-8	2003	The results show that the intracellular signaling heme level, reflected as Hap1 activity, is closely correlated with oxygen concentration.	Oxygen	117-123	Hap1p	Saccharomyces cerevisiae S288C	75-79
14644195-8	2003	Loss of function of OPA-1, analogous to deficiency of its yeast homologue, Mgm1p, is expected to lead to mitochondrial fission, loss of mitochondrial DNA, respiratory deficits and an increase in reactive oxygen species.	Oxygen	204-210	dynamin-related GTPase MGM1	Saccharomyces cerevisiae S288C	75-80
14645546-3	2003	Previous studies using Hif-1alpha(-/-) embryonic stem and mouse embryonic fibroblast cells show that loss of HIF-1alpha eliminates all oxygen-regulated transcriptional responses analyzed, suggesting that HIF-2alpha is dispensable for hypoxic gene regulation.	Oxygen	135-141	hypoxia inducible factor 1, alpha subunit	Mus musculus	109-119
29352221-3	2018	METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism.	Oxygen	52-58	electron transferring flavoprotein, beta polypeptide	Mus musculus	140-144
14667371-1	2003	The trend towards large size in marine animals with latitude, and the existence of giant marine species in polar regions have long been recognized, but remained enigmatic until a recent study showed it to be an effect of increased oxygen availability in sea water of a low temperature.	Oxygen	231-237	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	254-257
16140167-3	2005	These cystatin C-expressing PC12 cells showed remarkable resistance to high (50%) oxygen atmosphere.	Oxygen	82-88	cystatin C	Rattus norvegicus	6-16
29545920-4	2018	We found that hypoxia (1% O2) enhances IDO production in DCs, and this increase was dependent on the adenosine A3 receptor (A3R), but not A2aR or A2bR.	Oxygen	26-28	indoleamine 2,3-dioxygenase 1	Homo sapiens	39-42
16140167-4	2005	This resistance correlate with expression levels of cystatin C, demonstrating that cystatin C has a protective effect on high oxygen-induced cell death.	Oxygen	126-132	cystatin C	Rattus norvegicus	52-62
16140167-4	2005	This resistance correlate with expression levels of cystatin C, demonstrating that cystatin C has a protective effect on high oxygen-induced cell death.	Oxygen	126-132	cystatin C	Rattus norvegicus	83-93
12698263-4	2003	RESULTS: Tenocytes cultivated under normal oxygen pressure released measurable amounts of VEGF into their culture supernatants.	Oxygen	43-49	vascular endothelial growth factor A	Rattus norvegicus	90-94
29545920-7	2018	Hypoxia (1% O2) upregulated CD86, CD274, HLA-DR, and CD54, and downregulated CD40 and CD83 in DCs as compared to normoxia (21% O2).	Oxygen	12-14	CD274 molecule	Homo sapiens	34-39
12698263-6	2003	Hypoxic conditions alone (5% O(2)) raised VEGF secretion only 2-fold.	Oxygen	29-34	vascular endothelial growth factor A	Rattus norvegicus	42-46
16834173-1	2005	We report the study of the isomeric selective OH-initiated oxidation of 1,3-butadiene in the presence of O2 and NO using the LP/LIF technique.	Oxygen	105-107	LIF interleukin 6 family cytokine	Homo sapiens	128-131
29545920-7	2018	Hypoxia (1% O2) upregulated CD86, CD274, HLA-DR, and CD54, and downregulated CD40 and CD83 in DCs as compared to normoxia (21% O2).	Oxygen	12-14	CD83 molecule	Homo sapiens	86-90
29171706-3	2018	Taking CoP nanowire arrays grown on carbon cloth (denoted as CoP NWs/CC) as an example, the oxygen plasma engraving can trigger moderate CoOx species formation on the surface of the CoP NWs/CC, which is visually verified by the X-ray absorption fine structure, high-resolution transmission electron microscopy, and energy-dispersive spectrometer (EDS) mapping.	Oxygen	92-98	caspase recruitment domain family member 16	Homo sapiens	7-10
15918795-4	2005	In the present study, we report on the activation of the JAK2/STAT5 pathway (where JAK stands for Janus kinase and STAT stands for signal transduction and activator of transcription) by low oxygen in microvascular endothelial cells.	Oxygen	190-196	signal transducer and activator of transcription 5A	Homo sapiens	62-67
14572612-5	2003	When cultured at low cell density, MEFs from Gpx4(+/-) mice also showed retarded growth under normal culture conditions (20% oxygen) that was reversed by culturing under low oxygen (2% oxygen).	Oxygen	125-131	glutathione peroxidase 4	Mus musculus	45-49
29171706-3	2018	Taking CoP nanowire arrays grown on carbon cloth (denoted as CoP NWs/CC) as an example, the oxygen plasma engraving can trigger moderate CoOx species formation on the surface of the CoP NWs/CC, which is visually verified by the X-ray absorption fine structure, high-resolution transmission electron microscopy, and energy-dispersive spectrometer (EDS) mapping.	Oxygen	92-98	caspase recruitment domain family member 16	Homo sapiens	61-64
15944807-12	2005	These results suggest that EPO may be able to directly protect the myocardium against lethal reperfusion-induced injury and so offer the myocardium an additional clinical advantage over and above its ability to improve the oxygen carrying capacity of the blood.	Oxygen	223-229	erythropoietin	Rattus norvegicus	27-30
29171706-3	2018	Taking CoP nanowire arrays grown on carbon cloth (denoted as CoP NWs/CC) as an example, the oxygen plasma engraving can trigger moderate CoOx species formation on the surface of the CoP NWs/CC, which is visually verified by the X-ray absorption fine structure, high-resolution transmission electron microscopy, and energy-dispersive spectrometer (EDS) mapping.	Oxygen	92-98	caspase recruitment domain family member 16	Homo sapiens	61-64
12917387-4	2003	The pretreatment of the slice preparation with a phospholipase A2 (PLA2) inhibitor, para-bromophenacyl bromide, or a cytochrome p-450 inhibitor, 17-octadecynoic acid, significantly restored the membrane to the preexposure potential level after the reintroduction of oxygen and glucose.	Oxygen	266-272	phospholipase A2 group IB	Rattus norvegicus	67-71
14648482-4	2003	Oxygen appears to be a key factor controlling the mechanism of placentation by regulating the transcription of several genes, such as VEGF (vascular endothelial growth factor), leptin, etc.	Oxygen	0-6	leptin	Homo sapiens	177-183
16190887-5	2005	Survival of neurons in 20% O2 could be promoted by transfer of medium conditioned by neurons in 1% O2, or by pharmacological induction of hypoxia-inducible factor-1alpha (HIF-1alpha), suggesting a possible role for secreted factors under transcriptional regulation by HIF-1 in the trophic effects of hypoxia.	Oxygen	27-29	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-169
16190887-5	2005	Survival of neurons in 20% O2 could be promoted by transfer of medium conditioned by neurons in 1% O2, or by pharmacological induction of hypoxia-inducible factor-1alpha (HIF-1alpha), suggesting a possible role for secreted factors under transcriptional regulation by HIF-1 in the trophic effects of hypoxia.	Oxygen	27-29	hypoxia inducible factor 1, alpha subunit	Mus musculus	171-181
29171706-5	2018	More interestingly, this surface reorganization strategy by oxygen plasma engraving can also be effective to other electrocatalysts such as free-standing CoP, Co4 N, O-CoSe2 , and C-CoSe2 nanowires, which verifies the universality of the strategy.	Oxygen	60-66	caspase recruitment domain family member 16	Homo sapiens	154-157
14561617-0	2003	Relationship between the concentration of supplemental oxygen and signal intensity of CSF depicted by fluid-attenuated inversion recovery imaging.	Oxygen	55-61	colony stimulating factor 2	Homo sapiens	86-89
29165030-10	2018	Importantly, transfection of the phosphomimetic Tomm22 mutant in muscle cells with ablated Csnk2b restored their oxygen consumption rate comparable to wild-type levels.	Oxygen	113-119	translocase of outer mitochondrial membrane 22	Mus musculus	48-54
14561617-1	2003	BACKGROUND AND PURPOSE: Prior reports have described increased signal intensity (SI) of CSF on fluid-attenuated inversion recovery (FLAIR) images of anesthetized patients receiving 100% O(2).	Oxygen	186-190	colony stimulating factor 2	Homo sapiens	88-91
14561617-3	2003	We evaluated the relationship between the concentration of inhaled O(2) and the development of increased SI of CSF on FLAIR images.	Oxygen	67-71	colony stimulating factor 2	Homo sapiens	111-114
14561617-7	2003	RESULTS: SI of CSF significantly increased (P &lt;.05) in various locations, in both volunteers and patients breathing 100% O(2), when compared with SI in the same volunteers breathing room air.	Oxygen	124-128	colony stimulating factor 2	Homo sapiens	15-18
14561617-10	2003	CONCLUSION: Supplemental oxygen at 100% is a main cause of artifactual CSF hyperintensity on FLAIR images, regardless of the anesthetic drug used.	Oxygen	25-31	colony stimulating factor 2	Homo sapiens	71-74
16127459-3	2005	Abeta binds Cu2+ with very high affinity, forming a redox-active complex that catalyzes H2O2 production from O2 and cholesterol.	Oxygen	90-92	amyloid beta (A4) precursor protein	Mus musculus	0-5
15836437-7	2005	After the addition of catalase that removes the H2O2 necessary for NADH oxidation by apoplastic peroxidases, mitochondrial oxygen consumption could be measured in permeabilized cells.	Oxygen	123-129	catalase isozyme 1	Nicotiana tabacum	22-30
29061366-6	2018	The numbers of caspase-3-positive cells in both cortical layer 3 and the CA1 region in the hippocampus in the 6 h anesthesia exposure group with 21% oxygen were increased compared with the 6 h anesthesia exposure with 30% oxygen and control groups.	Oxygen	149-155	carbonic anhydrase 1	Rattus norvegicus	73-76
15987772-7	2005	Surprisingly, HIF1alpha and HIF2alpha were induced during TS cell differentiation in 20% O2; additionally, pVHL levels were modulated during the same time period.	Oxygen	89-91	hypoxia inducible factor 1, alpha subunit	Mus musculus	14-23
15987772-7	2005	Surprisingly, HIF1alpha and HIF2alpha were induced during TS cell differentiation in 20% O2; additionally, pVHL levels were modulated during the same time period.	Oxygen	89-91	endothelial PAS domain protein 1	Mus musculus	28-37
14565072-3	2003	During the ascent from sea level, atmospheric pressure and partial oxygen pressure decrease, humidity and temperature decrease, and radiation is elevated.	Oxygen	67-73	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
12782633-6	2003	LIF also conferred protection in 100% O2 where it decreased alveolar-capillary protein leak and enhanced survival.	Oxygen	38-40	leukemia inhibitory factor	Mus musculus	0-3
31015281-3	2018	So, we first deleted the vesicular glutamate transporter 2, necessary to load glutamate into synaptic vesicles, from neurons in the PB, and showed that this prevents awakening to high CO2 or low O2 We then showed that PB neurons that express calcitonin gene-related peptide (CGRP) show cFos staining during high CO2 Using CGRP-Cre-ER mice, we expressed the inhibitory opsin archaerhodopsin just in the PBCGRP neurons.	Oxygen	185-187	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Mus musculus	25-58
12782633-8	2003	LIF transgenic mice with a null mutation in IL-6 were more sensitive to the toxic effects of 100% O2 than LIF-transgenic animals with a wild-type IL-6 locus.	Oxygen	98-100	leukemia inhibitory factor	Mus musculus	0-3
15800659-3	2005	This system uses the oxygen-dependent degradation domain derived from hypoxia-inducible factor 1alpha as the hypoxia sensor and a double-vector system as signal amplifier.	Oxygen	21-27	hypoxia inducible factor 1, alpha subunit	Mus musculus	70-101
16036365-5	2005	The analysis of H2O2 formation upon oxidation of DOPA by O2*- using 1-hydroxy-3-carboxy-pyrrolidine (CP-H), and SOD as competitive reagents for superoxide provides consistent values of the rate constant for the reaction between DOPA and O2*- being equal to (3.4+/-0.6)x10(5) M(-1) s(-1).	Oxygen	57-59	carboxypeptidase E	Homo sapiens	101-105
28960000-0	2018	Time-resolved SERS study of the oxygen reduction reaction in ionic liquid electrolytes for non-aqueous lithium-oxygen cells.	Oxygen	32-38	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	14-18
16102054-2	2005	Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three co-substrates: reduced vitamin K, CO2, and O2.	Oxygen	174-176	gamma-glutamyl carboxylase	Homo sapiens	44-70
12873954-12	2003	In organotypic cultures of rat hippocampus, we show that protection of CA1, CA3, and dentate neurons by 1% isoflurane from death caused by oxygen and glucose deprivation involves GABA(A) receptors.	Oxygen	139-145	carbonic anhydrase 1	Rattus norvegicus	71-74
16102054-2	2005	Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three co-substrates: reduced vitamin K, CO2, and O2.	Oxygen	174-176	gamma-glutamyl carboxylase	Homo sapiens	72-76
28960000-0	2018	Time-resolved SERS study of the oxygen reduction reaction in ionic liquid electrolytes for non-aqueous lithium-oxygen cells.	Oxygen	111-117	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	14-18
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	secreted phosphoprotein 1	Homo sapiens	218-229
29212737-9	2018	Mechanistically, Lrp4 conditional knockout in astrocytes increased ATP release and the production of ATP derivative, adenosine, which were further elevated by oxygen and glucose deprivation.	Oxygen	159-165	low density lipoprotein receptor-related protein 4	Mus musculus	17-21
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	secreted phosphoprotein 1	Homo sapiens	231-234
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	secreted phosphoprotein 1	Homo sapiens	235-238
16024619-2	2005	VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	20-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	52-83
16024619-2	2005	VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	20-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-95
15983381-3	2005	Here, we show that DJ-1 protects against oxidative stress-induced cell death, but that its relatively modest ability to quench reactive oxygen species is insufficient to account for its more robust cytoprotective effect.	Oxygen	136-142	Parkinsonism associated deglycase	Homo sapiens	19-23
12811826-2	2003	We report that supraphysiologic concentrations of O(2) (hyperoxia) induced Egr-1 mRNA and protein expression in cultured alveolar epithelial cells, as well as in mouse lung in vivo.	Oxygen	50-54	early growth response 1	Mus musculus	75-80
12811826-9	2003	This forms a foundation for analysis of detailed mechanisms underlying Egr-1 activation during hyperoxia and understanding its consequences for regulating cell response to oxygen toxicity.	Oxygen	172-178	early growth response 1	Mus musculus	71-76
12927972-2	2003	Leghemoglobins regulate oxygen affinity through a mechanism different from that of myoglobin using a novel combination of heme pocket amino acids that lower the oxygen affinity.	Oxygen	161-167	myoglobin	Homo sapiens	83-92
12714601-8	2003	At low oxygen concentrations inside the intact potato tubers, FDH activity was strongly increased relative to cytochrome c oxidase activity pointing to a possible involvement of FDH in hypoxic metabolism.	Oxygen	7-13	formate dehydrogenase, mitochondrial	Solanum tuberosum	62-65
12714601-8	2003	At low oxygen concentrations inside the intact potato tubers, FDH activity was strongly increased relative to cytochrome c oxidase activity pointing to a possible involvement of FDH in hypoxic metabolism.	Oxygen	7-13	formate dehydrogenase, mitochondrial	Solanum tuberosum	178-181
29242645-4	2017	By contrast, retinal astrocytic differentiation was accelerated by the exposure of wild-type newborn mice to hyperoxia for 24 hours, or by APC specific deficiency in hypoxia inducible factor (HIF)-2alpha, an oxygen labile transcription factor.	Oxygen	208-214	endothelial PAS domain protein 1	Mus musculus	166-203
12832529-2	2003	In the current study, a role for NKCC1 in neuronal death was elucidated in neurotoxicity induced by glutamate and oxygen and glucose deprivation (OGD).	Oxygen	114-120	solute carrier family 12 member 2	Homo sapiens	33-38
15895398-7	2005	Thus, it appears that high oxygen in arterial blood is required for arterial expression of Dll4 and EphrinB2, which could be involved in cell-cell repulsion pathways that dictate the normal segregation of arteries and veins.	Oxygen	27-33	ephrin B2	Mus musculus	100-108
15988031-3	2005	Induction of Myc in P493-6 cells resulted in increased oxygen consumption and mitochondrial mass and function.	Oxygen	55-61	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-16
29242645-5	2017	These findings reveal a novel function of the retinal vasculature, and imply that in normal neonatal mice, oxygen from the retinal circulation may promote astrocytic differentiation, in part by triggering oxygen dependent HIF-2alpha degradation in astrocytic precursors.	Oxygen	107-113	endothelial PAS domain protein 1	Mus musculus	222-232
29242645-5	2017	These findings reveal a novel function of the retinal vasculature, and imply that in normal neonatal mice, oxygen from the retinal circulation may promote astrocytic differentiation, in part by triggering oxygen dependent HIF-2alpha degradation in astrocytic precursors.	Oxygen	205-211	endothelial PAS domain protein 1	Mus musculus	222-232
28953090-0	2017	Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	72-106
18370715-4	2005	RESULTS: The visceral fat area (VFA) and maximal oxygen uptake ([Formula: see text] O(2)max) were found to be significantly different within the tertiles regarding the leptin and adiponectin levels and the adiponectin-to-leptin (A/L) ratio.	Oxygen	49-55	leptin	Homo sapiens	168-174
12808484-13	2003	Moreover, alpha1-adrenergic receptors are present in the myocardium, and beta1-agonists, like beta-adrenergic agonists, increase myocardial oxygen consumption.	Oxygen	140-146	adrenoceptor alpha 1D	Homo sapiens	10-16
12730686-5	2003	CypA Arg55 guanidinium group probably facilitates catalysis by anchoring the substrate proline oxygen and stabilizing sp3 hybridization of the proline nitrogen in the transition state.	Oxygen	95-101	peptidylprolyl isomerase A	Homo sapiens	0-4
28978646-4	2017	Specific inhibition of mitoribosomal translation by doxycycline, chloramphenicol, or siRNA-mediated MRPL13 knockdown decreased mitochondrial protein expression, reduced oxygen consumption rate, and increased CLN1-mediated tumor cell invasiveness in SNU387 cells, which have active mitochondria.	Oxygen	169-175	mitochondrial ribosomal protein L13	Homo sapiens	100-106
12632405-4	2003	In the scaled-up bioprocess with a 5-L bioreactor, immobilized VHb-DAO (2500 U/L) resulted in 99% bioconversion of 120 mM cephalosporin C within 60 min at an oxygen flow rate of 0.2 (v/v) x min.	Oxygen	158-164	D-amino acid oxidase	Homo sapiens	67-70
15939090-2	2005	Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts.	Oxygen	39-41	carbonic anhydrase 1	Rattus norvegicus	131-134
29215556-5	2017	There are three kinds of oxygen chemical states in SnO2 and FTO NPs, in which Oalpha corresponds to oxygen vacancies.	Oxygen	25-31	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	60-63
15342428-7	2005	Antioxidants and lower oxygen tension reduced the high levels of neuronal death in primary cortical cultures derived from Ku70(-/-) mice, but not the low levels of cell death in wildtype cortical cultures.	Oxygen	23-29	X-ray repair complementing defective repair in Chinese hamster cells 6	Mus musculus	122-126
29215556-5	2017	There are three kinds of oxygen chemical states in SnO2 and FTO NPs, in which Oalpha corresponds to oxygen vacancies.	Oxygen	100-106	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	60-63
15914639-15	2005	CONCLUSIONS: These results support the hypothesis that endogenous EphrinB2 and EphB4 are regulators of retinal NV during oxygen-induced retinopathy and may be useful targets for therapeutic intervention.	Oxygen	121-127	ephrin B2	Mus musculus	66-74
12691841-0	2003	Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity.	Oxygen	38-44	myeloperoxidase	Rattus norvegicus	139-154
12759266-7	2003	Plasma leptin levels correlated positively with the degree of sleep-disordered breathing as recorded by the apnea-hypopnea index (r = 0.54, P =.001) and percentage of sleep time spent with oxygen saturation below 90% (r = 0.39, P =.02).	Oxygen	189-195	leptin	Homo sapiens	7-13
15900343-1	2005	The fabrication process of highly porous SnO(2) thick film by reaction between tin ions and oxygen gas generated by an anodic applied potential on substrates in SnCl(2) aqueous solution is reported; moreover, we succeeded in forming porous SnO(2) micropatterns through site-selective deposition on a Pt-patterned F-doped SnO(2)(FTO) coated substrate .	Oxygen	92-98	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	328-331
15916947-5	2005	This aerokinetic response is mediated by GCY-35 and GCY-36 sGCs, which appear to become activated as O2 levels drop and to depolarize the AQR, PQR, and URX neurons.	Oxygen	101-103	Soluble guanylate cyclase gcy-36	Caenorhabditis elegans	52-58
29276790-6	2017	Cellular adaptation to low oxygen is mediated by the transcription factors HIF-1alpha and HIF-2alpha.	Oxygen	27-33	endothelial PAS domain protein 1	Homo sapiens	90-100
15916947-6	2005	Coexpression of GCY-35 and GCY-36 is sufficient to transform olfactory neurons into O2 sensors.	Oxygen	84-86	Soluble guanylate cyclase gcy-36	Caenorhabditis elegans	27-33
15786505-1	2005	Intermediates in the oxygen atom transfer from Mo(VI) to P(III), [Tp(iPr)MoOX(OPR3)] (Tp(iPr) = hydrotris(3-isopropylpyrazol-1-yl)borate; X = Cl-, phenolates, thiolates), have been isolated from the reactions of [Tp(iPr)MoO2X] with phosphines (PEt3, PMePh2, PPh3).	Oxygen	21-27	protein phosphatase 4 catalytic subunit	Homo sapiens	258-262
12663857-7	2003	The results show that EPO markedly prevents the apoptosis of cultured adult rat myocardiocytes subjected to 28 h of hypoxia (approximately 3% normal oxygen).	Oxygen	149-155	erythropoietin	Rattus norvegicus	22-25
29276790-8	2017	This review focuses on the role of the oxygen sensing signaling in the regulation of hepatic glucose output with an emphasis on hypoxia inducible factor (HIF)-2alpha.	Oxygen	39-45	endothelial PAS domain protein 1	Homo sapiens	128-165
29276790-10	2017	Understanding the HIF-2alpha dependent mechanism in hepatic metabolism will greatly enhance our potential to utilize the oxygen sensing mechanisms to treat metabolic diseases.	Oxygen	121-127	endothelial PAS domain protein 1	Homo sapiens	18-28
12711393-2	2003	This myoglobin can bind oxygen reversibly, but has a lower oxygen affinity than vertebrate and invertebrate myoglobins.	Oxygen	24-30	myoglobin	Homo sapiens	5-14
12711393-2	2003	This myoglobin can bind oxygen reversibly, but has a lower oxygen affinity than vertebrate and invertebrate myoglobins.	Oxygen	59-65	myoglobin	Homo sapiens	5-14
15850390-9	2005	The second type of interaction is mediated by phospholipase C and protein kinase C. It triggers the synthesis of active oxygen species and pH changes.	Oxygen	120-126	phosphoinositide phospholipase C 2-like	Nicotiana tabacum	46-61
28214553-5	2017	Different approaches have been developed to deliver oxygen to tissues and cells, including hyperbaric oxygen therapy (HBOT), normobaric hyperoxia therapy (NBOT), using biochemical reactions and electrolysis, employing liquids with high oxygen solubility, administering hemoglobin, myoglobin and red blood cells (RBCs), introducing oxygen-generating agents, using oxygen-carrying microparticles, persufflation, and peritoneal oxygenation.	Oxygen	52-58	myoglobin	Homo sapiens	281-290
15653764-6	2005	In conscious chronically instrumented dogs, AT1 receptor blockade with telmisartan improved the balance between coronary blood flow and myocardial oxygen consumption in the high-fat-fed dogs but not in normal control dogs, i.e., the relationship between coronary venous Po2 and myocardial oxygen consumption was shifted upward, toward normal control values.	Oxygen	147-153	angiotensin II receptor type 1	Canis lupus familiaris	44-47
12659876-4	2003	By analyzing mRNA levels of leptin after stimulation of BeWo cells with insulin in the presence or absence of oxygen, we found a supraadditive effect when incubating hypoxic cells with insulin.	Oxygen	110-116	leptin	Homo sapiens	28-34
28839100-7	2017	Combining these with intratracheal (IT) instillations of lipopolysaccharide (LPS), we demonstrate that arterial oxygen saturation decline in response to IT-LPS in platelet-specific CLEC-2-deficient mice is significantly augmented.	Oxygen	112-118	C-type lectin domain family 1, member b	Mus musculus	181-187
12727804-10	2003	Comparison with other agents producing reactive oxygen in the cells, as reflected in heme oxygenase-1 induction, suggested cellular differentiation was suppressed by sustained but not transient generation of reactive oxygen.	Oxygen	48-54	heme oxygenase 1	Homo sapiens	85-101
15653764-6	2005	In conscious chronically instrumented dogs, AT1 receptor blockade with telmisartan improved the balance between coronary blood flow and myocardial oxygen consumption in the high-fat-fed dogs but not in normal control dogs, i.e., the relationship between coronary venous Po2 and myocardial oxygen consumption was shifted upward, toward normal control values.	Oxygen	289-295	angiotensin II receptor type 1	Canis lupus familiaris	44-47
16158973-0	2005	The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1.	Oxygen	35-41	interferon alpha inducible protein 27	Homo sapiens	12-15
28760745-0	2017	A PP2A-mediated feedback mechanism controls Ca2+-dependent NO synthesis under physiological oxygen.	Oxygen	92-98	protein phosphatase 2 phosphatase activator	Homo sapiens	2-6
16158973-6	2005	We, therefore, believe that p27 and not pRb is the mediator of this oxygen-dependent checkpoint in late G1.	Oxygen	68-74	interferon alpha inducible protein 27	Homo sapiens	28-31
12620994-2	2003	In order to investigate the role of oxygenation and metabolism in these processes, the oxygen-responsive component of the hypoxia-inducible factor (HIF) 1 complex, HIF1alpha, was deleted in the murine mammary gland.	Oxygen	36-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	164-173
28760745-5	2017	Enhanced expression and membrane targeting of PP2A-C was observed in 5% O2, resulting in greater interaction with eNOS in response to histamine.	Oxygen	72-74	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	46-52
12664087-1	2003	OBJECTIVE: To investigate whether the Agouti-related protein (Agrp), the melanocortin receptor antagonist, alters oxygen consumption, as a measure of energy expenditure.	Oxygen	114-120	agouti related neuropeptide	Rattus norvegicus	38-60
15820896-4	2005	Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center.	Oxygen	181-187	secreted phosphoprotein 1	Homo sapiens	39-43
12664087-1	2003	OBJECTIVE: To investigate whether the Agouti-related protein (Agrp), the melanocortin receptor antagonist, alters oxygen consumption, as a measure of energy expenditure.	Oxygen	114-120	agouti related neuropeptide	Rattus norvegicus	62-66
15820896-5	2005	The tetranuclear cluster cation of 2 has a cubane topology with the ZnII ions and the deprotonated oxygen atoms from the four eta1:eta3:eta1:mu3 (py)2C(OH)O- ligands occupying alternate vertices.	Oxygen	99-105	secreted phosphoprotein 1	Homo sapiens	126-130
28760745-6	2017	Moreover, increased dephosphorylation of eNOS in 5% O2 was Ca2+-sensitive and reversed by okadaic acid or PP2A-C siRNA.	Oxygen	52-54	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	106-112
15820896-5	2005	The tetranuclear cluster cation of 2 has a cubane topology with the ZnII ions and the deprotonated oxygen atoms from the four eta1:eta3:eta1:mu3 (py)2C(OH)O- ligands occupying alternate vertices.	Oxygen	99-105	secreted phosphoprotein 1	Homo sapiens	136-140
16392293-2	2005	Training at high altitude may improve performance at sea level through altitude acclimatisation, which improves oxygen transport and/or utilisation, or through hypoxia, which intensifies the training stimulus.	Oxygen	112-118	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
12664087-11	2003	CONCLUSION: Chronic CNS administration of Agrp decreases oxygen consumption and decreases the capacity of BAT to expend energy.	Oxygen	57-63	agouti related neuropeptide	Rattus norvegicus	42-46
12633750-8	2003	This is followed by oxygen transfer to the most electropositive carbon atoms, C-6, C-1, and C-3, with formation of 6-OHBP (and its quinones), 1-OHBP, and 3-OHBP, respectively, or the most electropositive 4,5-, 7,8-, and 9,10- double bonds, with formation of BP 4,5-, 7,8-, or 9,10-oxide.	Oxygen	20-26	complement C6	Rattus norvegicus	78-81
28585865-9	2017	Inhibiting arc also blocked PKCe-mediated neuroprotection against lethal oxygen and glucose deprivation.	Oxygen	73-79	protein kinase C epsilon	Homo sapiens	28-32
12511571-10	2003	Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells.	Oxygen	118-124	heme oxygenase 1	Homo sapiens	68-72
12614847-5	2003	As an intracellular oxygen sensor, heme stimulated TSA2 transcription by activating Hap1p.	Oxygen	20-26	Hap1p	Saccharomyces cerevisiae S288C	84-89
21171342-5	2005	RESULTS: sequence of a globin cDNA in Tibetans were the same with the registering globin genes in the GenBank, and Hb Abruzzo (beta143 (H21), His- > Arg) gene mutation, a high oxygen affinity beta globin mutation, was found in one Tibetan" beta goblin coding gene (CAC- > CGC).	Oxygen	176-182	hemoglobin subunit beta	Homo sapiens	21-29
15831755-3	2005	For terrestrial vertebrates during the Late Permian, the combination of a drop in atmospheric oxygen plus climate warming would have induced hypoxic stress and consequently compressed altitudinal ranges to near sea level.	Oxygen	94-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	211-214
28847650-4	2017	In the adult kidney, PHD oxygen sensors are differentially expressed in a cell type-dependent manner and control the production of erythropoietin in interstitial cells.	Oxygen	25-31	erythropoietin	Mus musculus	131-145
15653678-1	2005	The hypoxia-inducible factors 1alpha (HIF-1alpha) and 2alpha (HIF-2alpha) are key regulators of the transcriptional response to low oxygen and are closely related in domain architecture, DNA binding, and activation mechanisms.	Oxygen	132-138	endothelial PAS domain protein 1	Homo sapiens	62-72
15917612-5	2005	This indicates that beta-glucosidase productivity by Aspergillus niger C-6 is function of culture conditions, principally temperature, pH, culture medium conditions, and the oxygen supply given in the bioreactor.	Oxygen	174-180	beta-glucosidase	Zea mays	20-36
12543137-7	2003	A set of new nitrogen and oxygen-specific descriptors were developed especially for this data set to better encode structural features, which are believed to directly influence DHFR inhibition and selectivity.	Oxygen	26-32	dihydrofolate reductase	Homo sapiens	177-181
28986396-4	2017	After a 12 wk follow-up period, transgenic mice harboring three ACE (3ACE) gene copies displayed diminished WAT mass, lipid content in their carcasses, adipocyte hypotrophy, and higher resting oxygen uptake (Vo2) in comparison with animals with one ACE gene copy (1ACE) after long fasting (12 h).	Oxygen	193-199	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	64-67
12547721-9	2003	For normal pregnancy, tumor necrosis factor-alpha and depleted oxygen significantly increased TUNEL, Annexin V binding and ADP:ATP in CTs and syncytiotrophoblasts (STs).	Oxygen	63-69	annexin A5	Homo sapiens	101-110
15791003-4	2005	Furthermore, microglial enhancement of alpha-synuclein-mediated neurotoxicity depended on phagocytosis of alpha-synuclein and activation of NADPH oxidase with production of reactive oxygen species.	Oxygen	182-188	synuclein alpha	Homo sapiens	39-54
15857276-0	2005	Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy.	Oxygen	156-162	hypoxia inducible factor 1, alpha subunit	Mus musculus	104-135
28570975-7	2017	Higher oxygen values indicated water mixing of the Sea of Marmara during winter 2012.	Oxygen	7-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
15784505-5	2005	CONCLUSIONS: IUGR is characterized by lower circulating endostatin concentrations in the fetus and neonate, possibly because under lower oxygen concentrations an unbalanced state of angiogenesis stimulators versus inhibitors takes place.	Oxygen	137-143	collagen type XVIII alpha 1 chain	Homo sapiens	56-66
12559387-7	2003	Faster input of the second electron via cytochrome b(5) would result in formation of more of the activated oxygen that reacts with substrate to form product.	Oxygen	107-113	cytochrome b5 type A	Homo sapiens	40-55
28928219-0	2017	O2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases.	Oxygen	0-2	S-phase kinase associated protein 1	Homo sapiens	90-94
12671447-7	2003	Macrophage-inflammatory protein-1-alpha and monocyte chemotactic protein-1 levels also are inversely related to oxygen saturation, suggesting that severity of RSV disease may be linked to chemokine release.	Oxygen	112-118	C-C motif chemokine ligand 3	Homo sapiens	0-39
12671447-7	2003	Macrophage-inflammatory protein-1-alpha and monocyte chemotactic protein-1 levels also are inversely related to oxygen saturation, suggesting that severity of RSV disease may be linked to chemokine release.	Oxygen	112-118	C-C motif chemokine ligand 2	Homo sapiens	44-74
15876406-7	2005	For the aromatization process required for estrogen biosynthesis, the atoms of dioxygen are bonded to C-2 and C-19 of the C19-precursor.	Oxygen	79-87	complement C2	Homo sapiens	102-105
28928219-3	2017	Prolyl hydroxylation of Skp1 contributes to O2-dependent Dictyostelium development, but full glycosylation at that position is required for optimal O2 sensing.	Oxygen	44-46	S-phase kinase associated protein 1	Homo sapiens	24-28
29184538-13	2017	In DM1 patients, plasma irisin levels correlated negatively with oxygen consumption and positively with insulin resistance, while in DM2 patients plasma irisin levels positively correlated with fat mass at arms and legs levels.	Oxygen	65-71	fibronectin type III domain containing 5	Homo sapiens	24-30
15783194-2	2005	Exposure of this cobaltosulfoxide complex to oxygen gas leads to the formation of the corresponding metallosulfone complex, (C5H5)Co(PPh3)(eta1-CCTMS)[eta1-(S)-SO2(p-tolyl)], which was characterized by X-ray crystallography.	Oxygen	45-51	protein phosphatase 4 catalytic subunit	Homo sapiens	133-137
15783194-2	2005	Exposure of this cobaltosulfoxide complex to oxygen gas leads to the formation of the corresponding metallosulfone complex, (C5H5)Co(PPh3)(eta1-CCTMS)[eta1-(S)-SO2(p-tolyl)], which was characterized by X-ray crystallography.	Oxygen	45-51	secreted phosphoprotein 1	Homo sapiens	139-143
15783194-2	2005	Exposure of this cobaltosulfoxide complex to oxygen gas leads to the formation of the corresponding metallosulfone complex, (C5H5)Co(PPh3)(eta1-CCTMS)[eta1-(S)-SO2(p-tolyl)], which was characterized by X-ray crystallography.	Oxygen	45-51	secreted phosphoprotein 1	Homo sapiens	151-155
12524158-2	2003	Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candidates for association studies of PD.	Oxygen	120-126	glutathione S-transferase kappa 1	Homo sapiens	18-44
12524158-2	2003	Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candidates for association studies of PD.	Oxygen	120-126	glutathione S-transferase kappa 1	Homo sapiens	46-50
12524158-2	2003	Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candidates for association studies of PD.	Oxygen	120-126	glutathione S-transferase kappa 1	Homo sapiens	155-159
12708612-19	2003	Oxygen partial pressure can also direct the course of CCl4 hepatotoxicity.	Oxygen	0-6	C-C motif chemokine ligand 4	Homo sapiens	54-58
12708612-21	2003	Consequently, the location of CCl4-induced damage mirrors the oxygen gradient across the liver lobule.	Oxygen	62-68	C-C motif chemokine ligand 4	Homo sapiens	30-34
12777063-8	2003	These results suggest that almost all GPI-80 positive monocytes belong to a monocyte subpopulation that is superior in phagocytosis and reactive oxygen production, but inferior in antigen presentation.	Oxygen	145-151	vanin 2	Homo sapiens	38-44
15542544-3	2005	In this report, exposure of human lung fibroblasts to 95% O2 decreased the incorporation of thymidine into DNA at 6 h and the incorporation of leucine into protein beginning at 12 h. The reductions in DNA and protein synthesis were accompanied by increased phosphorylation of eIF4E protein and reduced phosphorylation of 4E-BP1.	Oxygen	58-60	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	321-327
15671158-2	2005	However, EPO administration can also raise the hemoglobin concentration, which, by increasing oxygen delivery, confounds assignment of cause and effect.	Oxygen	94-100	erythropoietin	Rattus norvegicus	9-12
29158891-5	2017	Oxygen-dependent (through pVHL, PHDs, calcium-mediated) and independent (through growth factor signaling pathway, mdm2 pathway, HSP90) regulation of HIF-1alpha leads to angiogenesis, metastasis, and cell survival.	Oxygen	0-6	heat shock protein 90 alpha family class A member 1	Homo sapiens	128-133
15650398-10	2005	HO-1 protein expression can occur in the lung in response to oxidative stress associated with infection, altered oxygen tension, and inflammatory diseases.	Oxygen	113-119	heme oxygenase 1	Homo sapiens	0-4
12509498-0	2003	Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans.	Oxygen	113-119	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-19
12509498-9	2003	The results demonstrate that CYP 2C9 plays an important role in the regulation of hyperaemia and oxygen uptake during exercise.	Oxygen	97-103	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	29-36
29693047-4	2018	Methods: We developed several transgenic mouse models based on the expression of an oxygen-stable form of HIF2alpha, or indirect stabilization of HIF proteins though deletion of von Hippel-Lindau, thus preventing HIF degradation.	Oxygen	84-90	endothelial PAS domain protein 1	Mus musculus	106-115
12835511-5	2003	Synaptosomes from p53-deficient mice exhibit increased resistance to oxidative and excitotoxic insults as indicated by stabilization of mitochondrial membrane potential and decreased production of reactive oxygen species.	Oxygen	206-212	transformation related protein 53, pseudogene	Mus musculus	18-21
12456885-5	2002	In sharp contrast, ablation of SOD2 has no overt effect on the development of larvae and pupae, which may reflect a fundamental transition in oxygen utilization andor reactive oxygen metabolism that occurs during metamorphosis from larval to adult life.	Oxygen	142-148	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	31-35
12456885-5	2002	In sharp contrast, ablation of SOD2 has no overt effect on the development of larvae and pupae, which may reflect a fundamental transition in oxygen utilization andor reactive oxygen metabolism that occurs during metamorphosis from larval to adult life.	Oxygen	176-182	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	31-35
15762196-4	2005	The main factors controlling O2- production by NOX2 are the cytosolic proteins p67phox and p47phox, and Rac, a small GTP-binding protein.	Oxygen	29-31	cytochrome b-245 beta chain	Canis lupus familiaris	47-51
15574355-8	2005	A three-dimensional model of CYP27B1 structure simulated on the basis of the crystal structure of rabbit CYP2C5 supports the experimental data from mutagenesis study of CYP27B1 that the mutated amino acid residues may be involved in protein folding, heme-propionate binding or activation of molecular oxygen.	Oxygen	301-307	cytochrome P450 2C5	Oryctolagus cuniculus	105-111
29039357-4	2017	The increased donor number density provided by the oxygen vacancies (confirmed by x-ray photoelectron data), and a possible reduction in the grain boundary energy or hematite crystal interface might favor charge separation, and increase the electron transfer through the hematite into the back contact (FTO substrate).	Oxygen	51-57	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	303-306
16116960-11	2005	It is concluded that the prolonged exposure to 85% O2 resulted in abnormal expression of Notch receptors, which might contribute to the pathogenesis of hyperoxia-induced lung injury in newborn rats.	Oxygen	51-53	notch receptor 1	Rattus norvegicus	89-94
12468948-3	2002	In this study, using the oxygen depleting agent thioglycolic acid we examined whether E-cadherin expressed on rat cultured gastric epithelial cells has protective actions against epithelial barrier dysfunction induced by chemical hypoxia-reoxygenation.	Oxygen	25-31	cadherin 1	Rattus norvegicus	86-96
29159034-4	2018	Arterial blood gas showed Type 1 Respiratory Failure (p02 was only 10 kPa on 4 L per minute of oxygen).	Oxygen	95-101	tumor protein, translationally-controlled 1	Homo sapiens	54-57
12446201-1	2002	Nitric oxide (NO) or its derivatives (reactive nitrogen species, RNS) inhibit mitochondrial respiration in two different ways: (i) an acute, potent, and reversible inhibition of cytochrome oxidase by NO in competition with oxygen; and, (ii) irreversible inhibition of multiple sites by RNS.	Oxygen	223-229	FAM20C golgi associated secretory pathway kinase	Homo sapiens	65-68
28840651-4	2017	The two lanthanide(III) ions in 1-7 are doubly bridged by two deprotonated aminophenoxide oxygen atoms of two mu2 :eta0 :eta1 :eta2 :eta1 :eta1 :eta0 -L2- ligands.	Oxygen	90-96	secreted phosphoprotein 1	Homo sapiens	121-125
12606820-8	2002	CONCLUSIONS: These results suggest that inhibition of the PI3K/Akt pathway can sensitize first-trimester trophoblast-like cells into oxygen-induced cell death and that EGF exerts its anti-apoptotic effect independently of PI3K/Akt.	Oxygen	133-139	epidermal growth factor	Homo sapiens	168-171
16491027-1	2005	Streptolysin O (SLO), an oxygen-labile cytolysin, is the cholesterol-binding exotoxin of hemolytic streptococci.	Oxygen	25-31	perforin 1	Homo sapiens	39-48
16291246-3	2005	The NO-derived induction of HO-1 caused (a) rapid elimination of toxic heme to inhibit lipid peroxidation and to prevent further induction of iNOS, (b) rapid production of bile pigment antioxidants to scavenge reactive oxygen (O2-) and nitrogen (NO) metabolites, and (c) rapid production of carbon monoxide (CO) to inhibit further production of O2- and NO by blocking the activities of NADPH-oxidase and iNOS, respectively.	Oxygen	219-225	heme oxygenase 1	Homo sapiens	28-32
16291246-3	2005	The NO-derived induction of HO-1 caused (a) rapid elimination of toxic heme to inhibit lipid peroxidation and to prevent further induction of iNOS, (b) rapid production of bile pigment antioxidants to scavenge reactive oxygen (O2-) and nitrogen (NO) metabolites, and (c) rapid production of carbon monoxide (CO) to inhibit further production of O2- and NO by blocking the activities of NADPH-oxidase and iNOS, respectively.	Oxygen	227-229	heme oxygenase 1	Homo sapiens	28-32
16291246-3	2005	The NO-derived induction of HO-1 caused (a) rapid elimination of toxic heme to inhibit lipid peroxidation and to prevent further induction of iNOS, (b) rapid production of bile pigment antioxidants to scavenge reactive oxygen (O2-) and nitrogen (NO) metabolites, and (c) rapid production of carbon monoxide (CO) to inhibit further production of O2- and NO by blocking the activities of NADPH-oxidase and iNOS, respectively.	Oxygen	345-347	heme oxygenase 1	Homo sapiens	28-32
16291246-4	2005	Thus, the NO overproduced by the O2- -dependent induction of iNOS expression can scavenge O2- to produce ONOO-, first to kill the invading pathogens and second to enhance the HO-1 expression in macrophages.	Oxygen	33-35	heme oxygenase 1	Homo sapiens	175-179
16291246-4	2005	Thus, the NO overproduced by the O2- -dependent induction of iNOS expression can scavenge O2- to produce ONOO-, first to kill the invading pathogens and second to enhance the HO-1 expression in macrophages.	Oxygen	90-92	heme oxygenase 1	Homo sapiens	175-179
12215445-2	2002	This suggests that leptin gene expression is enhanced in response to oxygen deficiency in this organ.	Oxygen	69-75	leptin	Homo sapiens	19-25
12236710-0	2002	Blue myoglobin reconstituted with an iron porphycene shows extremely high oxygen affinity.	Oxygen	74-80	myoglobin	Homo sapiens	5-14
12236710-6	2002	Interestingly, the O2 affinity of the reconstituted myoglobin, 1.1 x 109 M-1, is a significant 1,400-fold higher than that of the native myoglobin.	Oxygen	19-21	myoglobin	Homo sapiens	52-61
12236710-6	2002	Interestingly, the O2 affinity of the reconstituted myoglobin, 1.1 x 109 M-1, is a significant 1,400-fold higher than that of the native myoglobin.	Oxygen	19-21	myoglobin	Homo sapiens	137-146
12236710-8	2002	The net results come from the slow dissociation of the O2 ligand in the reconstituted myoglobin, koff = 0.11 s-1, because of the formation of strong hydrogen bond between His64 and negatively charged dioxygen.	Oxygen	55-57	myoglobin	Homo sapiens	86-95
12236710-8	2002	The net results come from the slow dissociation of the O2 ligand in the reconstituted myoglobin, koff = 0.11 s-1, because of the formation of strong hydrogen bond between His64 and negatively charged dioxygen.	Oxygen	200-208	myoglobin	Homo sapiens	86-95
16154284-0	2005	O2 sensing by recombinant TWIK-related halothane-inhibitable K+ channel-1 background K+ channels heterologously expressed in human embryonic kidney cells.	Oxygen	0-2	potassium two pore domain channel subfamily K member 13	Homo sapiens	26-73
16154284-2	2005	In the present study, we examined directly the O2 sensitivity of recombinant THIK-1 channels, expressed in human embryonic kidney (HE293) cells.	Oxygen	47-49	potassium two pore domain channel subfamily K member 13	Homo sapiens	77-83
16154284-5	2005	Hypoxia (P(O2), 20 mmHg) reversibly inhibited THIK-1 currents and caused membrane depolarization, effects that were occluded by halothane.	Oxygen	11-13	potassium two pore domain channel subfamily K member 13	Homo sapiens	46-52
28840651-4	2017	The two lanthanide(III) ions in 1-7 are doubly bridged by two deprotonated aminophenoxide oxygen atoms of two mu2 :eta0 :eta1 :eta2 :eta1 :eta1 :eta0 -L2- ligands.	Oxygen	90-96	secreted phosphoprotein 1	Homo sapiens	133-137
16154284-8	2005	Given the O2 sensitivity of THIK-1 channels and their abundant expression in the CNS, we raise for the first time the possibility of a physiological and/or pathological role for these channels during brain ischemia.	Oxygen	10-12	potassium two pore domain channel subfamily K member 13	Homo sapiens	28-34
12448820-8	2002	However, such embryotoxic effects of oxygen were significantly attenuated in the hTRX Tg embryos that continuously express hTRX.	Oxygen	37-43	thioredoxin	Homo sapiens	81-85
28840651-4	2017	The two lanthanide(III) ions in 1-7 are doubly bridged by two deprotonated aminophenoxide oxygen atoms of two mu2 :eta0 :eta1 :eta2 :eta1 :eta1 :eta0 -L2- ligands.	Oxygen	90-96	secreted phosphoprotein 1	Homo sapiens	133-137
12448820-8	2002	However, such embryotoxic effects of oxygen were significantly attenuated in the hTRX Tg embryos that continuously express hTRX.	Oxygen	37-43	thioredoxin	Homo sapiens	123-127
29095874-12	2017	Age-predicted O2 pulse ratio is significantly increased in MAD deficient subjects, indicating a greater efficiency of the cardiovascular system to deliver O2 (p &lt; 0.01, Scheffe"s post hoc test).	Oxygen	14-16	adenosine monophosphate deaminase 1	Homo sapiens	59-62
12169625-5	2002	Most importantly, G6PD is indispensable for survival when the embryo is exposed to oxygen through its blood supply.	Oxygen	83-89	glucose-6-phosphate dehydrogenase 2	Mus musculus	18-22
15756816-0	2005	Oxygen-binding heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin.	Oxygen	0-6	myoglobin	Homo sapiens	84-93
16222041-4	2005	Although KGF has potent mitogenic effects on epithelial cells, the proliferative effect of KGF was shown to be abolished in oxygen-breathing animals, but KGF was still able to inhibit alveolar damage.	Oxygen	124-130	fibroblast growth factor 7	Mus musculus	91-94
16222041-4	2005	Although KGF has potent mitogenic effects on epithelial cells, the proliferative effect of KGF was shown to be abolished in oxygen-breathing animals, but KGF was still able to inhibit alveolar damage.	Oxygen	124-130	fibroblast growth factor 7	Mus musculus	91-94
29095874-12	2017	Age-predicted O2 pulse ratio is significantly increased in MAD deficient subjects, indicating a greater efficiency of the cardiovascular system to deliver O2 (p &lt; 0.01, Scheffe"s post hoc test).	Oxygen	155-157	adenosine monophosphate deaminase 1	Homo sapiens	59-62
28912276-7	2017	We noted a high level of Cavin-2 expression in the neovascular tufts in the mouse model of oxygen-induced retinopathy, suggesting a role for Cavin-2 in pathogenic angiogenesis.	Oxygen	91-97	caveolae associated 2	Mus musculus	25-32
28912276-7	2017	We noted a high level of Cavin-2 expression in the neovascular tufts in the mouse model of oxygen-induced retinopathy, suggesting a role for Cavin-2 in pathogenic angiogenesis.	Oxygen	91-97	caveolae associated 2	Mus musculus	141-148
29045486-5	2017	Consistent with hypoxia/ischemia, TD stabilizes and activates Hypoxia Inducible Factor-1alpha (HIF-1alpha) under physiological oxygen levels.	Oxygen	127-133	hypoxia inducible factor 1, alpha subunit	Mus musculus	95-105
28709643-9	2017	Taken together, these findings establish a new link between HIF-2alpha and MAPK-signaling that mediates the adaptive regulation of mitochondrial gene expression under low oxygen tension.	Oxygen	171-177	endothelial PAS domain protein 1	Homo sapiens	60-70
31966350-0	2017	Anti-angiogenic effect of rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway.	Oxygen	45-51	hypoxia inducible factor 1, alpha subunit	Mus musculus	107-117
29043714-1	2017	Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively.	Oxygen	8-14	plexin A2	Homo sapiens	109-112
29043714-1	2017	Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively.	Oxygen	147-153	plexin A2	Homo sapiens	109-112
29186947-5	2017	Conversely, an increase in the expression of SOX9, beta-catenin, HIFs, collagen-I and II (p&lt;0.05) in migrating chondrocytes from low oxygen tension cultures was present.	Oxygen	136-142	catenin beta 1	Homo sapiens	51-88
27778208-5	2017	The minimum end-tidal oxygen partial pressure (EtO2) achieved was 40 mm Hg.	Oxygen	22-28	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	47-51
28601781-11	2017	Cys454-458-459Ala substitution abolished Src kinase activation in response to ouabain treatment, uncoupled Src from Erk signaling, and interfered with O2-sensitivity of Na,K-ATPase signaling function.	Oxygen	151-153	Rous sarcoma oncogene	Mus musculus	41-44
28963486-10	2017	In summary, HIF2alpha, rather than HIF1alpha, is most affected by reduced oxygen level during syncytialization and increases in HIF2alpha trigger a reduction of PlGF production.	Oxygen	74-80	endothelial PAS domain protein 1	Homo sapiens	12-21
28928465-9	2017	Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease treatment.	Oxygen	90-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	190-200
28840922-0	2017	A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1alpha and HIF-2alpha.	Oxygen	15-21	endothelial PAS domain protein 1	Homo sapiens	130-140
28840922-4	2017	We studied the hypoxic activation of the transcription factors HIF-1alpha and HIF-2alpha in human endothelial cells within a spatial linear gradient of oxygen.	Oxygen	152-158	endothelial PAS domain protein 1	Homo sapiens	78-88
28840922-7	2017	These results underscore the differences between HIF-1alpha and HIF-2alpha regulation and suggest that a microfluidic oxygen gradient is a novel tool for identifying distinct hypoxic signaling activation and interactions between differentially oxygenated cells.	Oxygen	118-124	endothelial PAS domain protein 1	Homo sapiens	64-74
28435049-3	2017	Using decidualized human immortalized endometrial stromal cells we tested the hypothesis that low oxygen tension or reduced leucine availability, believed to be common in placental insufficiency, increase the phosphorylation of decidual IGFBP-1.	Oxygen	98-104	insulin like growth factor binding protein 1	Homo sapiens	237-244
28764841-3	2017	NSTE-ACS is primarily due to an acute change in the supply and demand balance of coronary perfusion and myocardial oxygen consumption, because of the significant coronary artery obstruction presenting as plaque rupture or erosion.	Oxygen	115-121	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	5-8
28620826-5	2017	Treatment with ferrous sulfate, a ROS generator, resulted in decreased oxygen consumption in both control and alpha-synuclein overexpressing cells.	Oxygen	71-77	synuclein alpha	Homo sapiens	110-125
28855849-1	2017	BACKGROUND: The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT) participates in the hypoxia-inducible factor (HIF) pathway which senses a decline in cellular oxygen tension.	Oxygen	185-191	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	37-83
28855849-1	2017	BACKGROUND: The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT) participates in the hypoxia-inducible factor (HIF) pathway which senses a decline in cellular oxygen tension.	Oxygen	185-191	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	85-89
29100402-7	2017	In addition, our study reveals a putative cooperation between STK33 and other HSP90 client protein kinases involved in molecular and cellular events through which cancer cells ensure their survival by securing the oxygen and nutrient supply.	Oxygen	214-220	serine/threonine kinase 33	Homo sapiens	62-67
29100402-7	2017	In addition, our study reveals a putative cooperation between STK33 and other HSP90 client protein kinases involved in molecular and cellular events through which cancer cells ensure their survival by securing the oxygen and nutrient supply.	Oxygen	214-220	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
28684630-5	2017	Sirt3 depletion increased SOD2 acetylation, elevated mitochondrial O2  -, and diminished endothelial nitric oxide.	Oxygen	67-69	sirtuin 3	Mus musculus	0-5
28808304-5	2017	In vitro, both TET1 mRNA and protein expression levels in JEG3 cells were increased following exposure to 3% oxygen, and the migration and invasion capacities of JEG3 cells were up-regulated.	Oxygen	109-115	tet methylcytosine dioxygenase 1	Homo sapiens	15-19
28808304-6	2017	Furthermore, TET1 knockdown decreased the migration, invasion and proliferation of JEG3 cells exposed to 3% oxygen, and the expression of HIF1alpha and its downstream target genes was also decreased, which was related to hyper-methylation of the HIF1alpha promoter.	Oxygen	108-114	tet methylcytosine dioxygenase 1	Homo sapiens	13-17
28808304-7	2017	Finally, increased HIF1alpha protein expression reversed the inhibitory effect of TET1 knockdown on the migration and invasion of JEG3 cells exposed to 3% oxygen.	Oxygen	155-161	tet methylcytosine dioxygenase 1	Homo sapiens	82-86
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Oxygen	174-176	pyruvate dehydrogenase complex component X	Homo sapiens	98-102
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Oxygen	174-176	pyruvate dehydrogenase complex component X	Homo sapiens	330-334
28768907-5	2017	Murine leukemic progenitors derived from hematopoietic progenitor cells (HPCs) overexpressing a MYCN cDNA (MYCN-HPCs) require heme/porphyrin biosynthesis, accompanied by increased oxygen consumption, to fully engage in self-renewal and oncogenic transformation.	Oxygen	180-186	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	96-100
28479297-0	2017	Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1alpha to modulate hypoxic responses in chondrocytes.	Oxygen	15-21	NK3 homeobox 2	Mus musculus	0-6
12057636-4	2002	The main results of this study have led us to conclude that all dendrimer generations can bind oxygen stably, the fifth generation being the most affine to the myoglobin molecule, the natural carrier of blood oxygen.	Oxygen	95-101	myoglobin	Homo sapiens	160-169
12057636-4	2002	The main results of this study have led us to conclude that all dendrimer generations can bind oxygen stably, the fifth generation being the most affine to the myoglobin molecule, the natural carrier of blood oxygen.	Oxygen	209-215	myoglobin	Homo sapiens	160-169
12161498-6	2002	However, when the cells were exposed to hypoxic (1% oxygen) conditions, both the induction of 11 beta-HSD2 and trophoblast differentiation were prevented.	Oxygen	52-58	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	94-106
28479297-4	2017	In this work, we uncovered a novel pathway causing oxygen concentration-independent and proteasome-independent degradation of HIF-1alpha protein.	Oxygen	51-57	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-136
12161498-7	2002	Taken together, these results demonstrate for the first time that the expression of 11 beta-HSD2 is induced early during trophoblast differentiation, and hypoxia prevents this induction, indicating that placental 11 beta-HSD2 expression is subjected to regulation by the local oxygen environment.	Oxygen	277-283	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	84-96
12161498-7	2002	Taken together, these results demonstrate for the first time that the expression of 11 beta-HSD2 is induced early during trophoblast differentiation, and hypoxia prevents this induction, indicating that placental 11 beta-HSD2 expression is subjected to regulation by the local oxygen environment.	Oxygen	277-283	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	203-225
12163460-1	2002	Ionizing radiation (IR) and radical oxygen intermediates (ROIs) activate the early growth response-1 (Egr1) promoter through specific cis-acting sequences termed CArG elements.	Oxygen	36-42	early growth response 1	Homo sapiens	102-106
15385570-1	2004	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis by inducing the expression of a broad range of genes in a hypoxia-dependent manner.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
15385570-1	2004	Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a central role in oxygen homeostasis by inducing the expression of a broad range of genes in a hypoxia-dependent manner.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
15542365-8	2004	The data suggest that under weak light and high oxygen concentration the Chl fluorescence quenching results from interactions between oxygen and PSI, cyt b(6)f and Ndh.	Oxygen	48-54	GLIS family zinc finger 3	Homo sapiens	164-167
15530657-2	2004	Mutations of Drosophila ADAR (dADAR) results in neuronal dysfunction and hypersensitivity to oxygen deprivation.	Oxygen	93-99	Adenosine deaminase acting on RNA	Drosophila melanogaster	24-28
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	protein tyrosine kinase 2 beta	Homo sapiens	156-172
28371332-2	2017	In this work, we demonstrate for the first time that functionalization of methacrylamide chitosan (MAC) with aliphatic pentadecafluoro chains, to synthesize pentadecafluoro-octanoyl methacrylamide chitosan (MACF), enhances the antioxidant capacity of the MAC base hydrogel material, while being able to deliver oxygen for future enhanced wound healing applications.	Oxygen	311-317	microtubule actin crosslinking factor 1	Homo sapiens	207-211
12142346-1	2002	Expression of the zinc finger transcription factor early growth response gene-1 (Egr-1) is triggered rapidly after mechanical vascular injury or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene families to elicit a pathological response.	Oxygen	181-187	early growth response 1	Homo sapiens	51-79
15530657-2	2004	Mutations of Drosophila ADAR (dADAR) results in neuronal dysfunction and hypersensitivity to oxygen deprivation.	Oxygen	93-99	Adenosine deaminase acting on RNA	Drosophila melanogaster	30-35
15549823-6	2004	Endo/exo reaction selectivity is attributed to positive orbital interactions between the diene and the acrylate carbonyl oxygen in the endo s-cis transition structures.	Oxygen	121-127	mannosidase endo-alpha	Homo sapiens	0-4
15549823-6	2004	Endo/exo reaction selectivity is attributed to positive orbital interactions between the diene and the acrylate carbonyl oxygen in the endo s-cis transition structures.	Oxygen	121-127	mannosidase endo-alpha	Homo sapiens	135-139
12142346-1	2002	Expression of the zinc finger transcription factor early growth response gene-1 (Egr-1) is triggered rapidly after mechanical vascular injury or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene families to elicit a pathological response.	Oxygen	181-187	early growth response 1	Homo sapiens	81-86
28371332-3	2017	As such, MACF was shown to sequester more nitric oxide (p &lt; 0.01) and hydroxyl (p &lt; 0.0001) radicals as compared to the negative control even when delivering additional oxygen.	Oxygen	175-181	microtubule actin crosslinking factor 1	Homo sapiens	9-13
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	99-101	C2H2-type zinc finger family protein	Arabidopsis thaliana	38-45
12084065-10	2002	Using a semirecombinant cell-free system of oxidase activation consisting of recombinant p67phox, p47phox and Rac2, neutrophil membranes and arachidonic acid, we found that the S100A8/A9-dependent increase in the elicited oxidase activity corresponded to an increase in the turnover of the membrane-bound flavocytochrome b, but not to a change of affinity for NADPH or O2.	Oxygen	369-371	S100 calcium binding protein A8	Bos taurus	177-183
15269007-0	2004	Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutations.	Oxygen	23-29	SURF1 cytochrome c oxidase assembly factor	Homo sapiens	82-87
15500821-0	2004	Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy.	Oxygen	112-118	vascular endothelial growth factor A	Rattus norvegicus	28-32
15500821-9	2004	However, VEGF levels were approximately 48 and 78% higher on post-oxygen exposure day 0 and 2, respectively, in the group treated with alternating periods of 45 and 12.5% oxygen compared to the group treated with alternating periods of 40 and 15% oxygen.	Oxygen	66-72	vascular endothelial growth factor A	Rattus norvegicus	9-13
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	99-101	C2H2-type zinc finger family protein	Arabidopsis thaliana	179-186
15500821-9	2004	However, VEGF levels were approximately 48 and 78% higher on post-oxygen exposure day 0 and 2, respectively, in the group treated with alternating periods of 45 and 12.5% oxygen compared to the group treated with alternating periods of 40 and 15% oxygen.	Oxygen	171-177	vascular endothelial growth factor A	Rattus norvegicus	9-13
12164222-3	2002	The pharmacophore Ph1 consists of two oxygen atoms and four carbon atoms.	Oxygen	38-44	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	18-21
15500821-9	2004	However, VEGF levels were approximately 48 and 78% higher on post-oxygen exposure day 0 and 2, respectively, in the group treated with alternating periods of 45 and 12.5% oxygen compared to the group treated with alternating periods of 40 and 15% oxygen.	Oxygen	171-177	vascular endothelial growth factor A	Rattus norvegicus	9-13
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	99-101	C2H2-type zinc finger family protein	Arabidopsis thaliana	179-186
15500821-12	2004	The results of this study suggest the existence of a threshold in the rat model of OIR, such that a small change in blood oxygen profile triggers a disproportionate increase in subsequent neovascularization, which is accompanied by more dramatic changes of retinal VEGF level than VEGFR2 or PEDF level.	Oxygen	122-128	vascular endothelial growth factor A	Rattus norvegicus	265-269
15500821-12	2004	The results of this study suggest the existence of a threshold in the rat model of OIR, such that a small change in blood oxygen profile triggers a disproportionate increase in subsequent neovascularization, which is accompanied by more dramatic changes of retinal VEGF level than VEGFR2 or PEDF level.	Oxygen	122-128	kinase insert domain receptor	Rattus norvegicus	281-287
15474364-5	2004	Oxygen caused oxidative stress, decreased expression of neurotrophins, and inactivation of survival signaling proteins Ras, extracellular signal-regulated kinase (ERK 1/2), and protein kinase B (Akt).	Oxygen	0-6	protein tyrosine kinase 2 beta	Homo sapiens	177-193
12379950-1	2002	The thioredoxin system is a major line of cellular defence against oxygen damage.	Oxygen	67-73	thioredoxin	Homo sapiens	4-15
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	130-132	C2H2-type zinc finger family protein	Arabidopsis thaliana	38-45
12112237-2	2002	Under aerobic conditions oxygen control of gene expression is exerted through the activator Hap1 and the repressor Rox1.	Oxygen	25-31	Hap1p	Saccharomyces cerevisiae S288C	92-96
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	130-132	C2H2-type zinc finger family protein	Arabidopsis thaliana	179-186
28587993-5	2017	Surprisingly, Zinc-Finger Protein 12 (AtZAT12), which had previously been used as a reporter for H2O2, responded more strongly to O2- than to H2O2; moreover, the expression of an AtZAT12 promoter-reporter fusion (AtZAT12::Luc) was enhanced by diethyldithiocarbamate, which inhibits dismutation of O2- to H2O2.	Oxygen	130-132	C2H2-type zinc finger family protein	Arabidopsis thaliana	179-186
15461452-3	2004	Reduced PDO (PDO(red)) that lacks Fe(II) at the mononuclear metal site (PDO-APO) reacts slowly with O(2) (1.4 x 10(-3) s(-1) at 125 microM O(2) and 22 degrees C), presumably in a direct reaction with the Rieske center.	Oxygen	100-104	aminopeptidase O (putative)	Homo sapiens	76-79
28587993-6	2017	These results suggest that AtZAT12 is transcriptionally upregulated in response to O2-, and that AtZAT12::Luc may be a useful biosensor for detecting O2- generation in vivo.	Oxygen	83-85	C2H2-type zinc finger family protein	Arabidopsis thaliana	27-34
12019179-11	2002	Our data demonstrate that the HIF-1alpha-dependent response of a few cells is capable of sustaining the growth of the whole tumor, probably through the secretion of factors up-regulated under low oxygen conditions.	Oxygen	196-202	hypoxia inducible factor 1, alpha subunit	Mus musculus	30-40
28587993-6	2017	These results suggest that AtZAT12 is transcriptionally upregulated in response to O2-, and that AtZAT12::Luc may be a useful biosensor for detecting O2- generation in vivo.	Oxygen	83-85	C2H2-type zinc finger family protein	Arabidopsis thaliana	97-104
28587993-6	2017	These results suggest that AtZAT12 is transcriptionally upregulated in response to O2-, and that AtZAT12::Luc may be a useful biosensor for detecting O2- generation in vivo.	Oxygen	150-152	C2H2-type zinc finger family protein	Arabidopsis thaliana	27-34
28587993-6	2017	These results suggest that AtZAT12 is transcriptionally upregulated in response to O2-, and that AtZAT12::Luc may be a useful biosensor for detecting O2- generation in vivo.	Oxygen	150-152	C2H2-type zinc finger family protein	Arabidopsis thaliana	97-104
12109881-1	2002	After isolation from a pulp mill wastewater treatment facility, two yeast strains, designated SPT1 and SPT2, were characterized and used in the development of mediated biochemical oxygen demand (BOD) biosensors for wastewater.	Oxygen	180-186	Hir2p	Saccharomyces cerevisiae S288C	94-98
15535492-4	2004	Nasopharyngeal oxygen therapy consumed significantly less oxygen than mask administration (3.0+/-0.9 vs 6.7+/-2.1 l/min, P&lt;0.001) and was associated with significantly higher comfort than the mask (7.5+/-1.6 cm vs 5.2+/-1.8, P&lt;0.001).	Oxygen	15-21	ankyrin repeat and KH domain containing 1	Homo sapiens	195-199
28947973-0	2017	Hyperbaric oxygen protects type II collagen in interleukin-1beta-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway.	Oxygen	11-17	mitogen-activated protein kinase 8	Rattus norvegicus	124-127
15377896-4	2004	Results were similar in rats hemorrhaged to 40 mmHg for 1 h. Hypoxia alone, replicated by warm isolated hepatic ischemia in vivo or hepatocytes cultured under 1% oxygen, also resulted in JNK phosphorylation.	Oxygen	162-168	mitogen-activated protein kinase 8	Rattus norvegicus	187-190
12006670-2	2002	The HIF-1alpha protein is rapidly degraded in cells supplied with adequate oxygen but is stabilized in hypoxic cells.	Oxygen	75-81	hypoxia inducible factor 1, alpha subunit	Mus musculus	4-14
28947973-4	2017	Hyperbaric oxygen might plays similar roles with the JNK-specific inhibitor SP600125, inducing the increase of Sox-9 and COL2 expression.	Oxygen	11-17	mitogen-activated protein kinase 8	Rattus norvegicus	53-56
11929818-4	2002	A model fusion protein, oxygen-dependent degradation (ODD)-beta-galactosidase (beta-Gal), composed of a part of the ODD domain of hypoxia-inducible factor-1alpha fused to beta-Gal, showed increased stability in cultured cells under a hypoxia-mimic condition.	Oxygen	24-30	galactosidase, beta 1	Mus musculus	59-77
15265861-8	2004	Hypoxia (1% O2) strongly increased reactive oxygen species generation, hypoxia-inducible factor-1 and CHOP-10/GADD153 expression, and inhibited adipocyte differentiation.	Oxygen	12-14	DNA-damage inducible transcript 3	Mus musculus	102-109
28947973-6	2017	However, Hyperbaric oxygen can inhibits IL-1beta induced inflammatory response in chondrocytes though block the JNK/c-Jun signaling pathway and up-regulate the expression of Sox-9 and COL2.	Oxygen	20-26	mitogen-activated protein kinase 8	Rattus norvegicus	112-115
15265861-8	2004	Hypoxia (1% O2) strongly increased reactive oxygen species generation, hypoxia-inducible factor-1 and CHOP-10/GADD153 expression, and inhibited adipocyte differentiation.	Oxygen	12-14	DNA-damage inducible transcript 3	Mus musculus	110-117
11929818-4	2002	A model fusion protein, oxygen-dependent degradation (ODD)-beta-galactosidase (beta-Gal), composed of a part of the ODD domain of hypoxia-inducible factor-1alpha fused to beta-Gal, showed increased stability in cultured cells under a hypoxia-mimic condition.	Oxygen	24-30	hypoxia inducible factor 1, alpha subunit	Mus musculus	130-161
28704502-1	2017	PURPOSE: A previous study reported that low baseline cerebral oxygen saturation (ScO2) (&lt;=50%) measured with near-infrared spectroscopy was predictive of poor clinical outcomes after cardiac surgery.	Oxygen	62-68	synthesis of cytochrome C oxidase 2	Homo sapiens	81-85
11909946-3	2002	Here we describe evidence obtained by using wild-type and HIF-1 alpha nullizygous mouse embryonic fibroblasts (mEFs) that the induction of c-jun mRNA expression and c-Jun phosphorylation by prolonged hypoxia are completely dependent on the presence of the oxygen-regulated transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha).	Oxygen	256-262	hypoxia inducible factor 1, alpha subunit	Mus musculus	58-69
15288123-0	2004	Beta-carotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism.	Oxygen	108-114	matrix metallopeptidase 1	Homo sapiens	35-59
28587451-0	2017	Halogen Bonding in the Complexes of CH3I and CCl4 with Oxygen-Containing Halogen-Bond Acceptors.	Oxygen	55-61	C-C motif chemokine ligand 4	Homo sapiens	45-49
15039136-1	2004	Endothelial PAS domain protein-1 (EPAS1) regulates transcription of the genes encoding erythropoietin and vascular endothelial growth factor, which are important for maintaining oxygen homeostasis.	Oxygen	178-184	endothelial PAS domain protein 1	Homo sapiens	0-32
15039136-1	2004	Endothelial PAS domain protein-1 (EPAS1) regulates transcription of the genes encoding erythropoietin and vascular endothelial growth factor, which are important for maintaining oxygen homeostasis.	Oxygen	178-184	endothelial PAS domain protein 1	Homo sapiens	34-39
15075382-1	2004	The activation of poly(ADP-ribose) polymerase-1 (PARP-1) after exposure to nitric oxide or oxygen-free radicals can lead to cell injury via severe, irreversible depletion of NAD.	Oxygen	91-97	poly (ADP-ribose) polymerase 1	Rattus norvegicus	18-47
15075382-1	2004	The activation of poly(ADP-ribose) polymerase-1 (PARP-1) after exposure to nitric oxide or oxygen-free radicals can lead to cell injury via severe, irreversible depletion of NAD.	Oxygen	91-97	poly (ADP-ribose) polymerase 1	Rattus norvegicus	49-55
15294408-0	2004	Continuous intratracheal insufflation of oxygen improves the efficacy of mechanical chest compression-active decompression CPR.	Oxygen	41-47	cytochrome p450 oxidoreductase	Mus musculus	123-126
11733522-2	2002	All redox stations involved in electron transport from NADPH to oxygen are located in gp91(phox).	Oxygen	64-70	pleckstrin	Homo sapiens	91-95
11888900-5	2002	The relation of HIF-2 alpha expression to a recently described oxygen-dependent pathway of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02).	Oxygen	63-69	endothelial PAS domain protein 1	Homo sapiens	16-27
11888900-5	2002	The relation of HIF-2 alpha expression to a recently described oxygen-dependent pathway of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02).	Oxygen	63-69	endothelial PAS domain protein 1	Homo sapiens	172-183
15294408-1	2004	The aim of the present study was to compare the efficacy of intratracheal continuous insufflation of oxygen (CIO) with intermittent positive pressure ventilation (IPPV) regarding gas exchange and haemodynamics during mechanical chest compression-active decompression cardiopulmonary resuscitation (mCPR) provided by the LUCAS device.	Oxygen	101-107	cytochrome p450 oxidoreductase	Mus musculus	298-302
12062233-0	2002	Modulation of insulin-like growth factor-I production of cultured retinal vascular endothelial cells by oxygen, glucose and growth hormone.	Oxygen	104-110	insulin like growth factor 1	Bos taurus	14-42
28362162-4	2017	To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61.	Oxygen	108-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-158
12062233-7	2002	CONCLUSIONS: Oxygen turned out to be the sole modulating factor for IGF-I production of cultured retinal vascular endothelial cells.	Oxygen	13-19	insulin like growth factor 1	Bos taurus	68-73
11914039-2	2002	We hypothesize that O2-induced changes in the neonatal lung are mediated by Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R).	Oxygen	20-22	insulin-like growth factor 1	Rattus norvegicus	76-104
11914039-2	2002	We hypothesize that O2-induced changes in the neonatal lung are mediated by Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R).	Oxygen	20-22	insulin-like growth factor 1	Rattus norvegicus	106-111
11914039-9	2002	Western blots showed IGF-1 protein was increased after 72 h of O2 exposure compared to room air exposure (57 +/- 7 compared to 32 +/- 5 densitometric units; P &lt; 0.05; N = 3).	Oxygen	63-65	insulin-like growth factor 1	Rattus norvegicus	21-26
15215098-0	2004	Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension.	Oxygen	77-83	squalene monooxygenase	Saccharomyces cerevisiae S288C	17-21
28362162-4	2017	To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61.	Oxygen	108-114	cellular communication network factor 1	Homo sapiens	170-175
11914039-10	2002	The increase was inhibited when the cultures were exposed to 95% O2 in the presence of anti-IGF-1 antibody (28 +/- 4; P &lt; 0.05; N = 3).	Oxygen	65-67	insulin-like growth factor 1	Rattus norvegicus	92-97
11914039-11	2002	IGF-1 protein decreased in the presence of retinoic acid after oxygen exposure but not in room air.	Oxygen	63-69	insulin-like growth factor 1	Rattus norvegicus	0-5
15255782-11	2004	CONCLUSION: In hypoxaemia-reoxygenation injury the MMP-2 level was highly increased and was most elevated in the piglets resuscitated with 100% O(2).	Oxygen	144-148	matrix metallopeptidase 2	Sus scrofa	51-56
28506746-5	2017	To this end, we knockout BL-sir2(sir2 B. longum) and LA-sir2(sir2 L.acidophilus) in low oxygen level.	Oxygen	88-94	sirtuin 2	Homo sapiens	28-32
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	colony stimulating factor 1 receptor	Mus musculus	200-205
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	myeloblastosis oncogene	Mus musculus	231-236
11914039-12	2002	Immunostaining of O2-exposed lung showed IGF-1 was most abundant in airway and alveolar epithelial cells.	Oxygen	18-20	insulin-like growth factor 1	Rattus norvegicus	41-46
31966594-7	2017	PrA decreased reactive oxygen species (ROS) generation in RAW264.7 cells.	Oxygen	23-29	S100 calcium binding protein A6 (calcyclin)	Mus musculus	0-3
11900832-10	2002	Moreover, in the presence of tetraethylammonium (TEA), a majority of CA1 neurons impaled with Cs acetate-filled electrodes showed complete or partial recovery of the membrane potential after reintroducing oxygen and glucose.	Oxygen	205-211	carbonic anhydrase 1	Rattus norvegicus	69-72
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	protein tyrosine phosphatase, receptor type, C	Mus musculus	306-310
28641785-0	2017	Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.	Oxygen	71-77	hexokinase 2	Mus musculus	20-33
15180795-10	2004	CONCLUSIONS: The present results suggest that activation of the cellular oxygen-sensing mechanism induced by Co(2+) administration slightly facilitates an expression of VEGF but does not facilitate exercise-induced microvascular remodelling in hind-leg muscles.	Oxygen	73-79	vascular endothelial growth factor A	Rattus norvegicus	169-173
11809856-1	2002	NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage.	Oxygen	304-310	crystallin zeta	Homo sapiens	8-30
11809856-1	2002	NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage.	Oxygen	304-310	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	96-100
11969369-3	2002	HIF is primarily regulated through oxygen-dependent proteasomal destruction of the regulatory subunit, HIF-1 alpha or HIF-2 alpha.	Oxygen	35-41	endothelial PAS domain protein 1	Homo sapiens	118-129
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Oxygen	32-38	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	53-58
14754757-4	2004	The objective of this study was to test whether oxygen concentration regulates sGC expression in cultured rat pulmonary artery smooth muscle cells (rPaSMC).	Oxygen	48-54	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	79-82
14754757-6	2004	Compared with rPaSMC exposed to 20% oxygen, sGC alpha1 and beta1 subunit mRNA levels were markedly decreased in rPaSMC exposed to 0% and 3% oxygen.	Oxygen	140-146	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	44-47
14754757-8	2004	Compared with rPaSMC exposed to 20% oxygen, exposure of rPaSMC to 3% oxygen progressively decreased sGC subunit protein levels at 24 and 48 h. There was also a 30% and 50% decrease in sGC enzyme activity in cells exposed to hypoxia for 24 and 48 h (P &lt; 0.05 and P &lt; 0.001, respectively, as compared with cells maintained in normoxia).	Oxygen	69-75	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	100-103
14754757-8	2004	Compared with rPaSMC exposed to 20% oxygen, exposure of rPaSMC to 3% oxygen progressively decreased sGC subunit protein levels at 24 and 48 h. There was also a 30% and 50% decrease in sGC enzyme activity in cells exposed to hypoxia for 24 and 48 h (P &lt; 0.05 and P &lt; 0.001, respectively, as compared with cells maintained in normoxia).	Oxygen	69-75	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	184-187
15157168-4	2004	Many factors, such as cytokines and local oxygen concentrations, can regulate cellular levels of Mcl-1 via transcription and post-transcriptional modification, control the survival time of neutrophils within tissues and thereby influence the inflammatory response.	Oxygen	42-48	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	97-102
28641785-10	2017	CONCLUSIONS: These results indicate that acute albeit not chronic changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism.	Oxygen	120-126	hexokinase 2	Mus musculus	91-95
11742848-1	2002	It has been proposed that the activation state of pyruvate dehydrogenase (PDH) may influence the rate of skeletal muscle O2 uptake during the initial phase of exercise; however, this has not been directly tested in humans.	Oxygen	121-123	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	74-77
28693255-4	2017	Lack of oxygen activates hypoxia-inducible factor (HIF) protein, which is followed by the upregulation of growth factors, including vascular endothelial growth factor and activation of the RTK signaling pathway.	Oxygen	8-14	ret proto-oncogene	Homo sapiens	189-192
12489116-3	2002	Using treatment of cell cultures with hyperbaric oxygen (HBO) as a model for oxidative stress, we have shown an induction of HO-1 in isolated human lymphocytes after a single HBO exposure and protection of these cells against DNA damage by subsequent oxidative stress.	Oxygen	49-55	heme oxygenase 1	Homo sapiens	125-129
15283163-7	2004	Exposure of growth-arrested HRCs with hypoxia (1% O2) or TNF-alpha (10 ng/ml) for 24 hours increased the secretion rate of PAI-1 protein by about 2.0-fold, while 24-hour treatment with high glucose (450 mg/dl) did not increase PAI-1 secretion at all, compared with that of the control cells under normal glucose (100 mg/dl) and normoxia (18% O2).	Oxygen	50-52	serpin family E member 1	Homo sapiens	123-128
15283163-7	2004	Exposure of growth-arrested HRCs with hypoxia (1% O2) or TNF-alpha (10 ng/ml) for 24 hours increased the secretion rate of PAI-1 protein by about 2.0-fold, while 24-hour treatment with high glucose (450 mg/dl) did not increase PAI-1 secretion at all, compared with that of the control cells under normal glucose (100 mg/dl) and normoxia (18% O2).	Oxygen	50-52	serpin family E member 1	Homo sapiens	227-232
15283163-7	2004	Exposure of growth-arrested HRCs with hypoxia (1% O2) or TNF-alpha (10 ng/ml) for 24 hours increased the secretion rate of PAI-1 protein by about 2.0-fold, while 24-hour treatment with high glucose (450 mg/dl) did not increase PAI-1 secretion at all, compared with that of the control cells under normal glucose (100 mg/dl) and normoxia (18% O2).	Oxygen	342-344	serpin family E member 1	Homo sapiens	123-128
28623968-8	2017	The effect was exacerbated by culture at atmospheric oxygen concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, protein metabolism; apoptosis, inflammatory responses; and diminished trophoblast proliferation, differentiation, invasion, regeneration, and viability.	Oxygen	53-59	peroxisome proliferator activated receptor alpha	Homo sapiens	121-126
11810259-3	2002	JEN1 expression is also controlled by oxygen availability, but is unaffected by the absence of haem biosynthesis.	Oxygen	38-44	Jen1p	Saccharomyces cerevisiae S288C	0-4
28281372-6	2017	Also, INVOS-5100 determined ScO2 increased during CO/O2 (74.4 +- 7.5%) and O2 inhalation (73.1 +- 7.2%) compared to normoxia (68.9 +- 6.9%; p &lt; .001).	Oxygen	53-55	synthesis of cytochrome C oxidase 2	Homo sapiens	28-32
12793918-10	2002	However, infants requiring supplemental oxygen at 36 wks of gestational age had reduced L-selectin at 24 hrs of age (3.2/2.0-3.45 vs. 5.0/2.35-10.4 nmol/L, p =.004), whereas there was no difference in ICAM-1.	Oxygen	40-46	selectin L	Homo sapiens	88-98
12793918-12	2002	Low plasma L-selectin at 24 hrs of age predicts prolonged requirement for supplemental oxygen.	Oxygen	87-93	selectin L	Homo sapiens	11-21
15105052-8	2004	Most commonly antioxidants tested, superoxide dismutase, catalase, GSH and thiourea, were effective in the inhibition of t-BOOH-induced c-fos and c-jun mRNA transcription in normal fibroblasts suggesting, as expected, that different oxygen species are involved in the observed effects induced by the xenobiotic.	Oxygen	233-239	FBJ osteosarcoma oncogene	Mus musculus	136-141
15112219-8	2004	The observed kinetics are in agreement with a reaction mechanism in which the nitric oxide that is initially bound to the Fe(II) centre of myoglobin is displaced by oxygen in a reversible ligand-exchange reaction prior to an irreversible electron transfer.	Oxygen	165-171	myoglobin	Homo sapiens	139-148
28642596-6	2017	Functionally, SGBS adipocytes displayed higher ISO-induced basal leak respiration and overall oxygen consumption rate, along with increased triglyceride accumulation and insulin-stimulated glucose uptake.	Oxygen	94-100	glypican 3	Homo sapiens	14-18
16245124-2	2002	The latter finding set the stage for the discovery of a regulatory system, the ferredoxin/thioredoxin system, functional in photosynthesis in chloroplasts and oxygen-evolving photosynthetic prokaryotes.	Oxygen	159-165	thioredoxin	Homo sapiens	90-101
29606929-4	2017	Characterization of the cofactor-substituted myoglobin variants across three different carbene transfer reactions (cyclopropanation, N-H insertion, S-H insertion) revealed a major influence of the nature of metal center, its oxidation state and first-sphere coordination environment on the catalytic activity, stereoselectivity, and/or oxygen tolerance of these artificial metalloenzymes.	Oxygen	336-342	myoglobin	Homo sapiens	45-54
11743740-4	2001	Exposure of yeast to various nitrogen oxides, under a variety of conditions, revealed that the oxygen-dependent inhibition of Ace1 is due to the reaction of NO with O(2).	Oxygen	95-101	Cup2p	Saccharomyces cerevisiae S288C	126-130
11743740-4	2001	Exposure of yeast to various nitrogen oxides, under a variety of conditions, revealed that the oxygen-dependent inhibition of Ace1 is due to the reaction of NO with O(2).	Oxygen	165-169	Cup2p	Saccharomyces cerevisiae S288C	126-130
11751428-0	2001	Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment.	Oxygen	20-26	heme oxygenase 1	Homo sapiens	33-37
11751428-2	2001	Our previous studies on hyperbaric oxygen (HBO; i.e. exposure to pure oxygen under high ambient pressure) indicated clearly increased levels of HO-1 in lymphocytes of volunteers 24 h after HBO treatment (1 h at 1.5 bar).	Oxygen	35-41	heme oxygenase 1	Homo sapiens	144-148
11751428-2	2001	Our previous studies on hyperbaric oxygen (HBO; i.e. exposure to pure oxygen under high ambient pressure) indicated clearly increased levels of HO-1 in lymphocytes of volunteers 24 h after HBO treatment (1 h at 1.5 bar).	Oxygen	70-76	heme oxygenase 1	Homo sapiens	144-148
14985905-3	2004	The second is based on the use of a heavy atom salt and sodium sulfite as an oxygen scavenger to obtain room-temperature phosphorescence (HAI-RTP) in solution.	Oxygen	77-83	MORN repeat containing 4	Homo sapiens	142-145
17903964-8	2004	These studies not only establish the role of Gpx1 in preventing mitochondrial dysfunction in mouse brain after TBI, but also suggest the species of reactive oxygen responsible for this event.	Oxygen	157-163	glutathione peroxidase 1	Mus musculus	45-49
15287594-6	2004	Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease.	Oxygen	245-251	complement C2	Homo sapiens	97-105
15287594-6	2004	Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease.	Oxygen	245-251	complement C5	Homo sapiens	110-113
28461337-6	2017	In the presence of FMN, NADH, and flavin reductase, which reduces FMN to FMNH2 using NADH as the electron donor, mitoNEET mediates oxidation of NADH with a concomitant reduction of oxygen.	Oxygen	181-187	CDGSH iron sulfur domain 1	Homo sapiens	113-121
11717280-6	2001	Because the PAS domain participates in signal reception in a variety of sensory proteins, including sensors of molecular oxygen and redox state, a similar role was previously ascribed to it in ArcB.	Oxygen	121-127	hypothetical protein	Escherichia coli	193-197
28461337-8	2017	Compared with oxygen, ubiquinone-2 is more efficient in oxidizing the mitoNEET [2Fe-2S] clusters, suggesting that ubiquinone could be an intrinsic electron acceptor of the reduced mitoNEET [2Fe-2S] clusters in mitochondria.	Oxygen	14-20	CDGSH iron sulfur domain 1	Homo sapiens	70-78
15228161-10	2004	The enhancement of oxygen availability to muscles by rEPO, analogues, and mimetics constitutes one of the main challenges to doping control.	Oxygen	19-25	erythropoietin	Rattus norvegicus	53-57
28461337-8	2017	Compared with oxygen, ubiquinone-2 is more efficient in oxidizing the mitoNEET [2Fe-2S] clusters, suggesting that ubiquinone could be an intrinsic electron acceptor of the reduced mitoNEET [2Fe-2S] clusters in mitochondria.	Oxygen	14-20	CDGSH iron sulfur domain 1	Homo sapiens	180-188
28223336-8	2017	Of interest, in vitro culture of CTB or ST in low oxygen increases methylation in the same region, which correlates with delayed differentiation.	Oxygen	50-56	chitobiase	Homo sapiens	33-36
14714198-2	2004	ACC is oxidized at the expense of O(2) to yield ethylene, HCN, CO(2), and two waters.	Oxygen	34-38	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	58-61
11714773-4	2001	Remarkably, development of CTL at 2.5% oxygen is more sustained and the CTL much more lytic; and 3) hypoxic exposure and TCR-mediated activation are additive in enhancing levels of hypoxia response element-containing gene products in lymphocyte supernatants.	Oxygen	39-45	T cell receptor alpha variable 6-3	Mus musculus	121-124
11689685-1	2001	In Saccharomyces cerevisiae, heme directly mediates the effects of oxygen on transcription through the heme activator protein Hap1.	Oxygen	67-73	Hap1p	Saccharomyces cerevisiae S288C	126-130
27443384-0	2017	PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.	Oxygen	101-107	leukocyte immunoglobulin like receptor B3	Homo sapiens	0-4
11688986-5	2001	We show here that cobalt binds directly to HIF-2alpha in vitro with a high affinity and in an oxygen-dependent manner.	Oxygen	94-100	endothelial PAS domain protein 1	Homo sapiens	43-53
11688986-7	2001	Mutations within the oxygen-dependent degradation domain of HIF-2alpha prevented cobalt binding and led to accumulation of HIF-2alpha during normoxia.	Oxygen	21-27	endothelial PAS domain protein 1	Homo sapiens	60-70
11688986-7	2001	Mutations within the oxygen-dependent degradation domain of HIF-2alpha prevented cobalt binding and led to accumulation of HIF-2alpha during normoxia.	Oxygen	21-27	endothelial PAS domain protein 1	Homo sapiens	123-133
15091114-8	2004	These data provide evidence that in APP mice vascular oxidative stress precedes the development of parenchymal oxidative stress, and that Abeta-produced vascular reactive oxygen species are involved in the attendant attenuation in functional hyperemia.	Oxygen	171-177	amyloid beta (A4) precursor protein	Mus musculus	138-143
15198024-4	2004	The kinetic constants, determined at pH 7.0, were as follows: oxidation by the enzyme of reduced TMPD at pH 7.0 was characterized by KM = 0.86 mM and Vmax = 1.1 mumol O2/(min mg protein), and oxidation of reduced cytochrome c from horse heart was characterized by KM = 0.09 mM and Vmax = 0.9 mumol O2/(min mg protein) Cyanide inhibited ascorbate/TMPD oxidase activity (Ki = 4.5-5.0 microM).	Oxygen	167-169	cytochrome c, somatic	Equus caballus	213-225
27443384-3	2017	In the present study, the role of PirB is investigated in the survival and apoptosis of cerebral cortical neurons in cultured primary after oxygen and glucose deprivation (OGD)-induced injury.	Oxygen	140-146	leukocyte immunoglobulin like receptor B3	Homo sapiens	34-38
15198024-4	2004	The kinetic constants, determined at pH 7.0, were as follows: oxidation by the enzyme of reduced TMPD at pH 7.0 was characterized by KM = 0.86 mM and Vmax = 1.1 mumol O2/(min mg protein), and oxidation of reduced cytochrome c from horse heart was characterized by KM = 0.09 mM and Vmax = 0.9 mumol O2/(min mg protein) Cyanide inhibited ascorbate/TMPD oxidase activity (Ki = 4.5-5.0 microM).	Oxygen	298-300	cytochrome c, somatic	Equus caballus	213-225
28479269-2	2017	Although impairment of the cell response to hypoxia due to destabilization of the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), which regulates the expression of genes that help cells to cope with low oxygen tension, has been implicated in diabetes-associated disease, the molecular mechanisms involved remain elusive.	Oxygen	222-228	hypoxia inducible factor 1, alpha subunit	Mus musculus	103-134
14627695-0	2004	c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.	Oxygen	23-29	BCL2-antagonist/killer 1	Mus musculus	81-84
14627695-0	2004	c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.	Oxygen	23-29	transformation related protein 53, pseudogene	Mus musculus	108-111
14627695-4	2004	Fibroblasts from p53-/- mice that conditionally express c-Myc died in response to oxygen (but not serum) deprivation.	Oxygen	82-88	transformation related protein 53, pseudogene	Mus musculus	17-20
14627695-10	2004	Thus, oxygen deprivation-induced cell death in fibroblasts with deregulated expression of c-Myc is independent of p53 or HIF-1 status, but is dependent on the Bcl-2 family member Bax or Bak to initiate mitochondrial dependent cell death.	Oxygen	6-12	BCL2-antagonist/killer 1	Mus musculus	186-189
14715497-9	2004	Therefore, activation of PKC-betaII in endothelial cells during obesity suppressed NO regulation both at rest and in response to increased flow velocity and decreased oxygen availability.	Oxygen	167-173	phospholipase C, beta 2	Rattus norvegicus	25-35
11597906-3	2001	In oxygen-breathing mice, serum leptin was increased six- to sevenfold and its mRNA was upregulated in white adipose tissue.	Oxygen	3-9	leptin	Mus musculus	32-38
11739897-1	2001	The residue Asp87, which is in the calcium-binding loop of bovine alpha-lactalbumin (alpha-LA) and provides a side-chain carboxylate oxygen for ligand Ca(II) co-ordination, was substituted by either alanine or asparagine.	Oxygen	133-139	lactalbumin alpha	Bos taurus	85-93
11694184-8	2001	A step change in oxygen tension from 2% to 20% caused cells in the bioreactor to increase 17beta-estradiol secretion and shifted cell cycle from proliferation to differentiation, which were verified with the expression levels of cyclin B1 and p27(kip1).	Oxygen	17-23	cyclin B1	Homo sapiens	229-238
11694184-8	2001	A step change in oxygen tension from 2% to 20% caused cells in the bioreactor to increase 17beta-estradiol secretion and shifted cell cycle from proliferation to differentiation, which were verified with the expression levels of cyclin B1 and p27(kip1).	Oxygen	17-23	cyclin dependent kinase inhibitor 1B	Homo sapiens	247-251
28479269-2	2017	Although impairment of the cell response to hypoxia due to destabilization of the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), which regulates the expression of genes that help cells to cope with low oxygen tension, has been implicated in diabetes-associated disease, the molecular mechanisms involved remain elusive.	Oxygen	222-228	hypoxia inducible factor 1, alpha subunit	Mus musculus	136-146
11563840-3	2001	We previously demonstrated that incubation under reduced oxygen levels increases the in vitro invasiveness of trophoblast and breast carcinoma cells, an effect linked to elevated expression of the cell surface receptor for urokinase-type plasminogen activator (uPAR).	Oxygen	57-63	plasminogen activator, urokinase receptor	Homo sapiens	261-265
14573596-4	2004	These findings suggest an enzymatic role for Pirin, most likely in biological redox reactions involving oxygen, and provide compelling evidence that Pirin requires the participation of the metal ion for its interaction with Bcl-3 to co-regulate the NF-kappaB transcription pathway and the interaction with NFI in DNA replication.	Oxygen	104-110	BCL3 transcription coactivator	Homo sapiens	224-229
27909919-1	2017	It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O2-dependent oxidation of L-tryptophan to N-formylkynurenine.	Oxygen	160-162	indoleamine 2,3-dioxygenase 1	Homo sapiens	108-135
14684318-0	2004	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors.	Oxygen	60-66	steroid sulfatase	Homo sapiens	106-123
11563840-8	2001	These findings suggest an important role for oxygen in the regulation of cellular invasion, possibly in part through its effects on integrin and uPAR-mediated mechanisms of adhesion.	Oxygen	45-51	plasminogen activator, urokinase receptor	Homo sapiens	145-149
11560506-7	2001	Increased levels of eEF-2 phosphorylation in hibernators appear to be a component of the regulated shutdown of cellular functions that permits hibernating animals to tolerate severe reductions in cerebral blood flow and oxygen delivery capacity.	Oxygen	220-226	eukaryotic translation elongation factor 2	Homo sapiens	20-25
27909919-1	2017	It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O2-dependent oxidation of L-tryptophan to N-formylkynurenine.	Oxygen	160-162	indoleamine 2,3-dioxygenase 1	Homo sapiens	137-140
28257211-3	2017	Of particular interest in this regard, are the flavoproteins miniSOG and SOPP, both of which (1) contain the chromophore flavin mononucleotide, FMN, in a LOV-derived protein enclosure, and (2) photosensitize the production of singlet oxygen, O2(a1Deltag).	Oxygen	242-244	formin 1	Homo sapiens	144-147
11529735-4	2001	A free-energy barrier of 63.0 kcal/mol for the oxygen - to - oxygen migration of the CF3 group in trifluoromethyl formate (3) was calculated at the MP2/6-31+G level.	Oxygen	47-53	tryptase pseudogene 1	Homo sapiens	148-156
11529735-4	2001	A free-energy barrier of 63.0 kcal/mol for the oxygen - to - oxygen migration of the CF3 group in trifluoromethyl formate (3) was calculated at the MP2/6-31+G level.	Oxygen	61-67	tryptase pseudogene 1	Homo sapiens	148-156
14709911-6	2004	PAP-I was tolerant of replacement of a carbon atom at the 4-position of the L-pGlu moiety by a sulfur atom (L-OTCA), an oxygen atom (L-2-oxooxazolidine-4-carboxylic acid, L-OOCA) and an NH group (L-2-oxoimidazolidine-4-carboxylic acid, L-OICA).	Oxygen	120-126	pyroglutamyl-peptidase I	Rattus norvegicus	0-5
28257211-6	2017	Most notably, for both proteins, the rate constant for quenching of 3FMN by ground state oxygen, O2(X3Sigmag-), increases ~10-fold upon increasing the temperature from 10 to 43  C, while the oxygen-independent channels of triplet state deactivation are less affected.	Oxygen	89-95	formin 1	Homo sapiens	69-72
15237209-7	2004	These results show that transcription of both Cpt1b and Cpt2 is triggered at the morula stage, concomitantly with known increasing profiles of oxygen uptake and fatty acids oxidation.	Oxygen	143-149	carnitine palmitoyltransferase 1b, muscle	Mus musculus	46-51
11559350-5	2001	Thus, dioxygen binding to cytochrome P450 displays nonhyperbolic kinetic profiles in the presence of certain substrates; the latter, together with redox proteins such as cytochrome b5, can exert efficient control of the abortive breakdown of the oxyferrous intermediates formed.	Oxygen	6-14	cytochrome b5 type A	Homo sapiens	170-183
28257211-6	2017	Most notably, for both proteins, the rate constant for quenching of 3FMN by ground state oxygen, O2(X3Sigmag-), increases ~10-fold upon increasing the temperature from 10 to 43  C, while the oxygen-independent channels of triplet state deactivation are less affected.	Oxygen	97-99	formin 1	Homo sapiens	69-72
28257211-6	2017	Most notably, for both proteins, the rate constant for quenching of 3FMN by ground state oxygen, O2(X3Sigmag-), increases ~10-fold upon increasing the temperature from 10 to 43  C, while the oxygen-independent channels of triplet state deactivation are less affected.	Oxygen	191-197	formin 1	Homo sapiens	69-72
11601763-5	2001	CONCLUSIONS: This multiple-control system is of interest for spatially restricting transgene expression into hypoxic tumors, and for finely adjusting the expression level of a therapeutic protein to the oxygen supply in medical applications such as neoangiogenesis or the erythropoietin-mediated treatment of anemia.	Oxygen	203-209	erythropoietin	Mus musculus	272-286
11535660-1	2001	The mechanisms underlying the depression of evoked fast excitatory postsynaptic currents (EPSCs) following superfusion with medium deprived of oxygen and glucose (in vitro ischemia) for a 4-min period in hippocampal CA1 neurons were investigated in rat brain slices.	Oxygen	143-149	carbonic anhydrase 1	Rattus norvegicus	216-219
15686271-0	2004	Regional CBF in chronic stable TBI treated with hyperbaric oxygen.	Oxygen	59-65	CCAAT enhancer binding protein zeta	Homo sapiens	9-12
14664574-1	2003	RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 degrees C gives the corresponding alpha-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and unsymmetrical 1,2-diamines, in excellent yields.	Oxygen	91-97	ATM serine/threonine kinase	Homo sapiens	101-104
14664591-2	2003	A selectivity of 230:20:1 was determined for alkylation of phenol at oxygen, C-4 and C-2 to form 1-OPh and biphenyls 1-(4-C6H4OH) and 1-(2-C6H4OH), respectively, and of 2:2:1 for alkylation of the corresponding nucleophilic sites of phenoxide ion in diffusion-limited reactions.	Oxygen	69-75	complement C2	Homo sapiens	85-88
14664591-6	2003	The 230-fold larger rate constant for O-compared to C-2-alkylation of phenol is due primarily to the larger thermodynamic driving force for oxygen addition.	Oxygen	140-146	complement C2	Homo sapiens	52-55
28299616-11	2017	Moreover, SGLT-2 inhibitors might improve the efficiency of myocardial energetics by offering beta-hydroxybutyrate as an attractive fuel for oxidation and increase hematocrit improving oxygen transport.	Oxygen	185-191	solute carrier family 5 member 2	Homo sapiens	10-16
14615405-6	2003	Preexposure (24 h) in a combination of low O2 and low glucose concentrations decreased the protein content of the HO-1 isoform by 59.6% (P &lt; 0.05), whereas preexposure (24 h) to low glucose concentration alone increased HO-2 content by 28.2% in chorionic villi explants (P &lt; 0.05).	Oxygen	43-45	heme oxygenase 1	Homo sapiens	114-118
11413138-1	2001	The phagocyte NADPH-dependent oxidase generates superoxide (O(2)) by reducing molecular oxygen through flavocytochrome b(558) (flavocytochrome b), a heterodimeric oxidoreductase composed of gp91(phox) and p22(phox) subunits.	Oxygen	88-94	calcineurin like EF-hand protein 1	Homo sapiens	205-208
28146458-13	2017	Phosphokinase arrays revealed that different O2 concentrations activated distinct sets of cytoprotective and cell death-associated kinases, including mitogen-activated protein kinases, Src kinases, p53, Akt, mitogen-activated and stress-activated kinase, Lyn, Lck, p70S6, signal transducers and activators of transcription 5b and 6, glycogen synthase kinase 3a/b and 5" AMP-activated protein kinases 1/2.	Oxygen	45-47	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	260-263
11471095-6	2001	MIP-1alpha and MCP-1 levels also were inversely related to oxygen saturation (P&lt;.005).	Oxygen	59-65	C-C motif chemokine ligand 3	Homo sapiens	0-10
11471095-6	2001	MIP-1alpha and MCP-1 levels also were inversely related to oxygen saturation (P&lt;.005).	Oxygen	59-65	C-C motif chemokine ligand 2	Homo sapiens	15-20
14614042-8	2003	The CP-M induction on cultured EVT under 20% O(2) concentration was significantly higher than that under 1% O(2) concentration.	Oxygen	45-49	carboxypeptidase M	Homo sapiens	4-8
14614042-8	2003	The CP-M induction on cultured EVT under 20% O(2) concentration was significantly higher than that under 1% O(2) concentration.	Oxygen	108-112	carboxypeptidase M	Homo sapiens	4-8
28063215-6	2017	The neuronal HIF-1alpha increase was dependent on inhibition of PHD2, an oxygen-dependent HIF-1alpha degrading enzyme, whereas astrocytic one was independent of PHD2.	Oxygen	73-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	13-23
12952974-5	2003	We have investigated the mechanism of macrophage iron efflux, focusing on the role of ceruloplasmin (Cp), a copper protein with a potent ferroxidase activity that converts Fe2+ to Fe3+ in the presence of molecular oxygen.	Oxygen	214-220	ceruloplasmin	Homo sapiens	86-99
14652683-11	2003	CONCLUSION: Hypoxia regulates MCP-1 expression under both basal and cytokine-stimulated conditions, suggesting that reduced oxygen supply is an important factor that mediates chemotaxis of monocytes to the area of inflammation.	Oxygen	124-130	C-C motif chemokine ligand 2	Homo sapiens	30-35
11371554-0	2001	Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation.	Oxygen	151-153	peroxisome proliferator activated receptor alpha	Homo sapiens	21-69
28063215-6	2017	The neuronal HIF-1alpha increase was dependent on inhibition of PHD2, an oxygen-dependent HIF-1alpha degrading enzyme, whereas astrocytic one was independent of PHD2.	Oxygen	73-79	egl-9 family hypoxia-inducible factor 1	Mus musculus	64-68
11457915-2	2001	It is shown here that treatments generating active oxygen species (high light combined with low temperature, gamma irradiation or methyl viologen treatment) result in potato CDSP34 gene induction and protein accumulation in leaves.	Oxygen	51-57	light-induced protein, chloroplastic	Solanum tuberosum	174-180
14597115-2	2003	Both the FAB and ES mass spectra were very similar and showed the presence of ions corresponding to carbon- and oxygen centered spin adducts (DMPO/L*, DMPO/LO*, and DMPO/LOO*).	Oxygen	112-118	FA complementation group B	Homo sapiens	9-12
28063215-6	2017	The neuronal HIF-1alpha increase was dependent on inhibition of PHD2, an oxygen-dependent HIF-1alpha degrading enzyme, whereas astrocytic one was independent of PHD2.	Oxygen	73-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	90-100
27738746-8	2017	In brown adipocytes of HIF-1alpha++ mice, oxygen consumption decreased ~50 % in association with reduced mitochondrial content, uncoupling protein 2, and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1alpha).	Oxygen	42-48	hypoxia inducible factor 1, alpha subunit	Mus musculus	23-33
14554226-0	2003	Effects of transcutaneous topical injection of oxygen on vascular endothelial growth factor gene into the healing ligament in rats.	Oxygen	47-53	vascular endothelial growth factor A	Rattus norvegicus	57-91
14554226-5	2003	However, the expression of VEGF mRNA in the topical oxygen injection group (Group C) was lower than that in control group (p&lt;0.05).	Oxygen	52-58	vascular endothelial growth factor A	Rattus norvegicus	27-31
14554226-6	2003	Our results suggest that oxygen is able to accelerate vessel formation in spite of its effect of decreasing VEGF mRNA.	Oxygen	25-31	vascular endothelial growth factor A	Rattus norvegicus	108-112
28224331-0	2017	The interaction of CCl4 with Ng (Ng = He, Ne, Ar), O2, D2O and ND3: rovibrational energies, spectroscopic constants and theoretical calculations.	Oxygen	51-53	C-C motif chemokine ligand 4	Homo sapiens	19-23
14617310-12	2003	CONCLUSION: The ability of 42-day-old AS-3 RBCs to deliver oxygen after rejuvenation and freezing is not impaired.	Oxygen	59-65	PDS5 cohesin associated factor B	Homo sapiens	38-42
28224331-1	2017	This investigation generated rovibrational energies and spectroscopic constants for systems of CCl4 with Ng (Ng = He, Ne, Ar), O2, D2O and ND3 from scattering experimental data, and the results presented are of interest for microwave spectroscopy studies of small halogenated molecules.	Oxygen	127-129	C-C motif chemokine ligand 4	Homo sapiens	95-99
12920134-3	2003	Therefore, we tested the hypothesis that, as in liver, it could mediate the inhibition of protein synthesis by oxygen deprivation in heart by modulating the phosphorylation of eukaryotic elongation factor-2 (eEF2), which becomes inactive in its phosphorylated form.	Oxygen	111-117	eukaryotic translation elongation factor 2	Homo sapiens	176-206
12920134-3	2003	Therefore, we tested the hypothesis that, as in liver, it could mediate the inhibition of protein synthesis by oxygen deprivation in heart by modulating the phosphorylation of eukaryotic elongation factor-2 (eEF2), which becomes inactive in its phosphorylated form.	Oxygen	111-117	eukaryotic translation elongation factor 2	Homo sapiens	208-212
12730073-2	2003	Previous studies have determined that both interleukin (IL)-6 and IL-11 are protective in oxygen toxicity.	Oxygen	90-96	interleukin 11	Homo sapiens	66-71
28115494-8	2017	Involvement of HIF1A and EPAS1 (also known as HIF2A), two HIF isoforms expressed in trophoblasts, was shown by treating another group of cells cultured under 2.5% O2 with specific inhibitors of HIF1A and EPAS1 for 16 h. INHA mRNA expression was assessed by real-time PCR and secreted inhibin A was quantified by ELISA.	Oxygen	163-165	endothelial PAS domain protein 1	Homo sapiens	25-30
12963966-3	2003	PFKFB3 also has been implicated in the high glycolytic rate of cancer cells that occurs despite adequate oxygen, a phenomenon known as the Warburg effect.	Oxygen	105-111	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	0-6
14526226-2	2003	Treatment with IGF-I, IGF-II, or IGFBP-LI (2 microg/mL) significantly (P &lt; 0.05) reduced CA1 damage in organotypic hippocampal cultures resulting from 35 minutes of oxygen and glucose deprivation by 71%, 60%, and 40%, respectively.	Oxygen	168-174	insulin like growth factor 2	Homo sapiens	22-28
14526232-6	2003	In response to hyperbaric oxygen (HBO2) at 5 ATA, WT and nNOS-/- mice showed decreases in rCBF over 30 minutes, but eNOS-/- mice did not.	Oxygen	26-32	nitric oxide synthase 3, endothelial cell	Mus musculus	116-120
28115494-8	2017	Involvement of HIF1A and EPAS1 (also known as HIF2A), two HIF isoforms expressed in trophoblasts, was shown by treating another group of cells cultured under 2.5% O2 with specific inhibitors of HIF1A and EPAS1 for 16 h. INHA mRNA expression was assessed by real-time PCR and secreted inhibin A was quantified by ELISA.	Oxygen	163-165	endothelial PAS domain protein 1	Homo sapiens	46-51
28115494-12	2017	Main Results and the Role of Chance: HIF1 protein stabilization with DMOG and DFX increased 21% O2-induced INHA mRNA and protein upregulation (P &lt; 0.05 versus control), while hypoxia-induced INHA upregulation was repressed by HIF1A and EPAS1 inhibitors (P &lt; 0.05 versus control).	Oxygen	96-98	endothelial PAS domain protein 1	Homo sapiens	239-244
28115494-14	2017	Overexpression of both HIF1A and EPAS1 under 21% O2 increased cloned INHA transcriptional activity (P &lt; 0.001 versus control).	Oxygen	49-51	endothelial PAS domain protein 1	Homo sapiens	33-38
27880021-4	2017	Root growth, O2 uptake, flux of carbon between sucrose and CO2 , levels of reactive oxygen species and some tricarboxylic acid cycle intermediates were positively correlated with levels of NDPK1 expression.	Oxygen	13-15	nucleoside diphosphate kinase	Solanum tuberosum	189-194
12972598-2	2003	PASKIN is related to the Rhizobium oxygen sensor protein FixL and to AMP-regulated kinases.	Oxygen	35-41	PAS domain containing serine/threonine kinase	Mus musculus	0-6
12883655-8	2003	Both the carboxyl-terminal and amino-terminal AgRP fragments significantly decreased oxygen consumption and colonic temperature.	Oxygen	85-91	agouti related neuropeptide	Rattus norvegicus	46-50
28255277-7	2017	Complex I, II, III, IV, and V activities, oxygen consumption and mitochondrial membrane potential were significantly decreased by SIRT3 knockdown.	Oxygen	42-48	sirtuin 3	Mus musculus	130-135
28182733-3	2017	At oxygen deprivation, hypoxia inducible factor 1alpha (HIF-1alpha) is known to induce glycolytic enzymes as well as suppressing mitochondrial energy production by inducing pyruvate dehydrogenase kinase 1 (Pdk1) in most cell types.	Oxygen	3-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	23-54
12914767-1	2003	Superoxide dismutase (SOD) is known to protect organisms from reactive oxygen metabolites.	Oxygen	71-77	superoxide dismutase [Cu-Zn]	Drosophila sechellia	22-25
12926963-3	2003	In the first step, Pro-1 acts as a general base to abstract a proton from the third carbon of the substrate, 2-oxo-4-hexenedioate, creating a negative charge on the oxygen at C-2 of this substrate.	Oxygen	165-171	lamin A/C	Homo sapiens	19-24
12926963-3	2003	In the first step, Pro-1 acts as a general base to abstract a proton from the third carbon of the substrate, 2-oxo-4-hexenedioate, creating a negative charge on the oxygen at C-2 of this substrate.	Oxygen	165-171	complement C2	Homo sapiens	175-178
28182733-3	2017	At oxygen deprivation, hypoxia inducible factor 1alpha (HIF-1alpha) is known to induce glycolytic enzymes as well as suppressing mitochondrial energy production by inducing pyruvate dehydrogenase kinase 1 (Pdk1) in most cell types.	Oxygen	3-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	56-66
28148750-9	2017	This is analogous to the evolutionary adaptation of haemoglobin to the needs of O2 transport across the animal kingdom and supports the hypothesis that Cx26 is an important and universal CO2 sensor in homeotherms.	Oxygen	80-82	complement C2	Homo sapiens	187-190
12899610-7	2003	The Sir2s are proposed to form a relatively stable covalent intermediate between ADPR and the acetyl oxygen of the acetyllysine-protein substrate.	Oxygen	101-107	sirtuin 1	Mus musculus	4-8
27780767-1	2017	Superoxide dismutase 1 (SOD- 1) is an antioxidant enzyme that regulates the levels of Reactive oxygen species (ROS) by catalyzing the conversion of superoxide radical into hydrogen peroxide (H2O2) and oxygen.	Oxygen	95-101	superoxide dismutase 1, soluble	Gallus gallus	0-22
12734177-3	2003	In this paper, we have performed detailed bioenergetic analyses of the function of PGC-1alpha and its homolog PGC-1beta in muscle cells by monitoring simultaneously oxygen consumption and membrane potential.	Oxygen	165-171	PPARG coactivator 1 alpha	Sus scrofa	83-93
27780767-1	2017	Superoxide dismutase 1 (SOD- 1) is an antioxidant enzyme that regulates the levels of Reactive oxygen species (ROS) by catalyzing the conversion of superoxide radical into hydrogen peroxide (H2O2) and oxygen.	Oxygen	95-101	superoxide dismutase 1, soluble	Gallus gallus	24-30
28241318-2	2017	Methods: The expression of nAChR subtypes and VEGF signaling pathway components was assessed in mice with and without oxygen-induced ischemic retinopathy by comparing expression levels at postnatal day (P) 14 and P17 in mice exposed to 75% oxygen from P7 to P12 and returned to room air versus mice pups that were exposed to ambient oxygen levels during the same period.	Oxygen	118-124	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	27-32
14592558-5	2003	In both species, administration of COX inhibitors resulted in redistribution of blood flow from hypoxic alveoli (N2-ventilated lung) to the well-oxygenated alveoli (O2-ventilated lung) and an increase in arterial oxygen tension, i.e., a COX-mediated AA metabolite or metabolites opposed hypoxic pulmonary vasoconstriction (HPV), but, by virtue of this activity, prevented optimal matching of ventilation with perfusion.	Oxygen	165-167	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	35-38
14592558-5	2003	In both species, administration of COX inhibitors resulted in redistribution of blood flow from hypoxic alveoli (N2-ventilated lung) to the well-oxygenated alveoli (O2-ventilated lung) and an increase in arterial oxygen tension, i.e., a COX-mediated AA metabolite or metabolites opposed hypoxic pulmonary vasoconstriction (HPV), but, by virtue of this activity, prevented optimal matching of ventilation with perfusion.	Oxygen	145-151	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	35-38
18969077-2	2003	Using oxygen scavenger to achieve significant or more sensitive RTP signals may bring about kinds of trouble in many cases and is apparently not very convenient in procedures.	Oxygen	6-12	MORN repeat containing 4	Homo sapiens	64-67
18969077-4	2003	Herein, we present a new named anti-oxygen-quenching RTP system using deoxycholate as a rigid medium.	Oxygen	36-42	MORN repeat containing 4	Homo sapiens	53-56
28241318-2	2017	Methods: The expression of nAChR subtypes and VEGF signaling pathway components was assessed in mice with and without oxygen-induced ischemic retinopathy by comparing expression levels at postnatal day (P) 14 and P17 in mice exposed to 75% oxygen from P7 to P12 and returned to room air versus mice pups that were exposed to ambient oxygen levels during the same period.	Oxygen	240-246	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	27-32
28241318-2	2017	Methods: The expression of nAChR subtypes and VEGF signaling pathway components was assessed in mice with and without oxygen-induced ischemic retinopathy by comparing expression levels at postnatal day (P) 14 and P17 in mice exposed to 75% oxygen from P7 to P12 and returned to room air versus mice pups that were exposed to ambient oxygen levels during the same period.	Oxygen	240-246	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	27-32
12870648-0	2003	Oxygen supply modulates MCP-1 release in monocytes from young and aged rats: decrease of MCP-1 transcription and translation is age-related.	Oxygen	0-6	C-C motif chemokine ligand 2	Rattus norvegicus	24-29
12870648-0	2003	Oxygen supply modulates MCP-1 release in monocytes from young and aged rats: decrease of MCP-1 transcription and translation is age-related.	Oxygen	0-6	C-C motif chemokine ligand 2	Rattus norvegicus	89-94
12870648-2	2003	Monocyte chemotactic protein-1 (MCP-1), an important chemotactic cytokine can be activated by active oxygen species.	Oxygen	101-107	C-C motif chemokine ligand 2	Rattus norvegicus	0-30
28153090-4	2017	Here, we used a serotype 8 rAAV bearing the Y733F mutation (rAAV8-733) to overexpress co-chaperone E3 ligase CHIP (also known as Stub-1) in rat hippocampal neurons, both in an oxygen and glucose deprivation model in vitro and in a four-vessel occlusion model of ischemia in vivo.	Oxygen	176-182	STIP1 homology and U-box containing protein 1	Rattus norvegicus	129-135
12870648-2	2003	Monocyte chemotactic protein-1 (MCP-1), an important chemotactic cytokine can be activated by active oxygen species.	Oxygen	101-107	C-C motif chemokine ligand 2	Rattus norvegicus	32-37
12870648-7	2003	We conclude that hyperoxia is an important regulator of MCP-1 release and support the hypothesis that increased % of O2 may serve to initiate MCP-1 production which then serves to recruit and regulate the distribution of mononuclear cells to the sites of inflammation.	Oxygen	117-119	C-C motif chemokine ligand 2	Rattus norvegicus	142-147
28249151-4	2017	We used quantitative RT-PCR to measure BRCA1 and NBR2 transcript levels in 0% and 1% oxygen in MCF-7 breast cancer cells and found that NBR2 transcript levels increased as a function of time under hypoxic conditions, whereas BRCA1 mRNA levels were repressed.	Oxygen	85-91	neighbor of BRCA1 lncRNA 2	Homo sapiens	49-53
28215263-7	2017	Leptin correlated with oxygen desaturation index (r = -0.17, p = 0.03), adiponectin correlated with mean oxygen saturation (r = 0.24, p = 0.002) and with the percentage of sleep time with an oxygen saturation &gt;95% (r = 0.25, p = 0.001).	Oxygen	23-29	leptin	Homo sapiens	0-6
12649278-0	2003	Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes.	Oxygen	37-43	heme oxygenase 1	Homo sapiens	82-98
28128298-1	2017	The MOF with the encapsulated CO2 molecule shows that the CO2 molecule is ligated to the unsaturated Cu(II) sites in the cage using its Lewis basic oxygen atom via an angular eta1-(OA) coordination mode and also interacts with Lewis basic nitrogen atoms of the tetrazole ligands using its Lewis acidic carbon atom.	Oxygen	148-154	secreted phosphoprotein 1	Homo sapiens	175-179
12809621-4	2003	Characterization of one of these mutants resulted in the identification of a dADAR gene that plays a role in the sensitivity to low levels of oxygen.	Oxygen	142-148	Adenosine deaminase acting on RNA	Drosophila melanogaster	77-82
27942616-2	2017	The SERS enhancement factor (EF) of metal oxide semiconductors like alpha-MoO3 and V2O5 can be greatly enhanced and the SERS performance can be optimized according to the detecting analyte and activating laser wavelength by introducing oxygen vacancy defects.	Oxygen	236-242	seryl-tRNA synthetase 1	Homo sapiens	4-8
12730463-0	2003	Ferritin: at the crossroads of iron and oxygen metabolism.	Oxygen	40-46	ferritin-1, chloroplastic	Glycine max	0-8
12730463-5	2003	Reversible formation and dissolution of a solid nanomineral-hydrated, iron oxide is the main function of ferritin, which additionally detoxifies excess iron and possibly dioxygen and reactive oxygen.	Oxygen	170-178	ferritin-1, chloroplastic	Glycine max	105-113
12730463-5	2003	Reversible formation and dissolution of a solid nanomineral-hydrated, iron oxide is the main function of ferritin, which additionally detoxifies excess iron and possibly dioxygen and reactive oxygen.	Oxygen	172-178	ferritin-1, chloroplastic	Glycine max	105-113
11432979-2	2001	A large body of data suggests that the Alzheimer"s amyloid peptide (Abeta) causes degeneration and death of neurons by mechanisms that involve reactive oxygen species.	Oxygen	152-158	amyloid beta (A4) precursor protein	Mus musculus	68-73
27942616-2	2017	The SERS enhancement factor (EF) of metal oxide semiconductors like alpha-MoO3 and V2O5 can be greatly enhanced and the SERS performance can be optimized according to the detecting analyte and activating laser wavelength by introducing oxygen vacancy defects.	Oxygen	236-242	seryl-tRNA synthetase 1	Homo sapiens	120-124
12730463-6	2003	Ferritin is a large multifunctional, multisubunit protein with eight Fe transport pores, 12 mineral nucleation sites and up to 24 oxidase sites that produce mineral precursors from ferrous iron and oxygen.	Oxygen	198-204	ferritin-1, chloroplastic	Glycine max	0-8
12730463-8	2003	Ferritin with varying H/L ratios is related to cell-specific iron and oxygen homeostasis.	Oxygen	70-76	ferritin-1, chloroplastic	Glycine max	0-8
27881662-4	2017	We found that O2 levels regulate the subcellular localization and channel activity of the polycystin complex through its interaction with the O2-sensing prolyl hydroxylase domain containing protein EGLN3 (or PHD3), which hydroxylates PC1.	Oxygen	14-16	polycystin 1, transient receptor potential channel interacting	Homo sapiens	234-237
12958837-9	2003	CONCLUSION: A hydrogen-bond between 14-methyl group of (-) huperzine A and the main-chain oxygen of His 440 is necessary for the highly acetylcholinesterase inhibitory activity of huperzine A.	Oxygen	90-96	acetylcholinesterase	Rattus norvegicus	136-156
11381139-8	2001	In addition, cultured Arnt2(-/-) neurons display decreased hypoxic induction of HIF-1 target genes, demonstrating formally that ARNT2/HIF-1alpha complexes regulate oxygen-responsive genes.	Oxygen	164-170	hypoxia inducible factor 1, alpha subunit	Mus musculus	134-144
27881662-5	2017	Moreover, cells lacking PC1 expression use less O2 and show less mitochondrial Ca2+ uptake in response to bradykinin-induced ER Ca2+ release, indicating that PC1 can modulate mitochondrial function.	Oxygen	48-50	polycystin 1, transient receptor potential channel interacting	Homo sapiens	24-27
11356821-0	2001	Selected Contribution: Osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation.	Oxygen	88-94	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-55
11356821-5	2001	In addition, we found that acute oxygen deprivation (4-12 h of 2% O2) resulted in a 2.1- to 3.7-fold upregulation of HIF-1alpha protein expression in MLO-Y4 osteocyte-like cells compared with cells cultured in parallel under normal oxygen conditions.	Oxygen	33-39	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
11356821-5	2001	In addition, we found that acute oxygen deprivation (4-12 h of 2% O2) resulted in a 2.1- to 3.7-fold upregulation of HIF-1alpha protein expression in MLO-Y4 osteocyte-like cells compared with cells cultured in parallel under normal oxygen conditions.	Oxygen	66-68	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
11356821-5	2001	In addition, we found that acute oxygen deprivation (4-12 h of 2% O2) resulted in a 2.1- to 3.7-fold upregulation of HIF-1alpha protein expression in MLO-Y4 osteocyte-like cells compared with cells cultured in parallel under normal oxygen conditions.	Oxygen	232-238	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
11336512-1	2001	The von Hippel-Lindau tumor-suppressor protein (pVHL) regulates the stability of HIF1 alpha and HIF2 alpha and thus is pivotal in cellular responses to changes in oxygen tension.	Oxygen	163-169	endothelial PAS domain protein 1	Homo sapiens	96-106
11336512-5	2001	As cytotrophoblasts attached to and invaded the uterus, which results in their increased exposure to oxygen, pVHL staining was abruptly downregulated concordant with localization of HIF2 alpha to the nucleus.	Oxygen	101-107	endothelial PAS domain protein 1	Homo sapiens	182-192
11336512-6	2001	In vitro, hypoxia (2% O(2)) upregulated cytotrophoblast pVHL expression together with HIF2 alpha, which localized to the cytoplasm; culture under well-oxygenated conditions greatly reduced levels of both molecules.	Oxygen	22-26	endothelial PAS domain protein 1	Homo sapiens	86-96
12690074-7	2003	A dipeptide mimicking inhibitor complexed to the active site discloses key determinants for substrate recognition, including a Glu-Glu motif that distinguishes DP IV as an aminopeptidase and an oxyanion trap that binds and activates the P(2)-carbonyl oxygen necessary for efficient postproline cleavage.	Oxygen	251-257	dipeptidyl peptidase 4	Homo sapiens	160-165
12688426-7	2003	The data indicate that IDPc plays an important role in cellular defense against singlet oxygen-induced oxidative injury.	Oxygen	88-94	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	23-27
27353127-6	2017	Results Peak oxygen uptake evolved in the PS0, PS3 and PS6 groups from 11.5 +- 2.3 to 12.6 +- 2.8 and 12.0 +- 2.7 mL/kg/min, respectively.	Oxygen	13-19	taste 2 receptor member 6 pseudogene	Homo sapiens	47-50
11320218-8	2001	A Krogh cylinder model calculation holding for steady-state tissue oxygenation predicts that, based on these myoglobin diffusivities, myoglobin-facilitated oxygen diffusion contributes 4% to the overall intracellular oxygen transport of maximally exercising skeletal muscle and less than 2% to that of heart under conditions of high work load.	Oxygen	67-73	myoglobin	Homo sapiens	134-143
11320218-8	2001	A Krogh cylinder model calculation holding for steady-state tissue oxygenation predicts that, based on these myoglobin diffusivities, myoglobin-facilitated oxygen diffusion contributes 4% to the overall intracellular oxygen transport of maximally exercising skeletal muscle and less than 2% to that of heart under conditions of high work load.	Oxygen	156-162	myoglobin	Homo sapiens	109-118
11320218-8	2001	A Krogh cylinder model calculation holding for steady-state tissue oxygenation predicts that, based on these myoglobin diffusivities, myoglobin-facilitated oxygen diffusion contributes 4% to the overall intracellular oxygen transport of maximally exercising skeletal muscle and less than 2% to that of heart under conditions of high work load.	Oxygen	156-162	myoglobin	Homo sapiens	134-143
27848178-1	2017	The TET dioxygenases, TET1, TET2, and TET3, catalyze transfer of an oxygen atom to the methyl group of 5-methylcytocine (5-mC), converting it to 5-hydroxymethylcytocine (5-hmC).	Oxygen	10-16	tet methylcytosine dioxygenase 1	Homo sapiens	22-26
11743896-8	2001	Insulin 1 U/kg for 9 weeks apparently decreased the production of O2.- (P &lt; 0.01) in liver mitochondria of diabetic rats.	Oxygen	66-68	insulin 1	Rattus norvegicus	0-9
11292626-0	2001	Endothelial nitric oxide synthase plays an essential role in regulation of renal oxygen consumption by NO.	Oxygen	81-87	nitric oxide synthase 3, endothelial cell	Mus musculus	0-33
27902963-1	2017	BACKGROUND: Hypoxia-inducible factor 2 alpha (HIF2alpha), prolyl hydroxylase domain protein 2 (PHD2), and the von Hippel Lindau tumor suppressor protein (pVHL) are three principal proteins in the oxygen-sensing pathway.	Oxygen	196-202	endothelial PAS domain protein 1	Homo sapiens	12-44
27902963-1	2017	BACKGROUND: Hypoxia-inducible factor 2 alpha (HIF2alpha), prolyl hydroxylase domain protein 2 (PHD2), and the von Hippel Lindau tumor suppressor protein (pVHL) are three principal proteins in the oxygen-sensing pathway.	Oxygen	196-202	endothelial PAS domain protein 1	Homo sapiens	46-55
11507908-3	2001	The radicals CCl3 and CHCl2 were able to react with O2 to form CCl3O2 and CHCl2O2 respectively, or to form C2Cl6 and C2H2Cl4 without O2.	Oxygen	52-54	C-C motif chemokine ligand 3	Homo sapiens	13-17
27902963-2	2017	Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha.	Oxygen	90-96	endothelial PAS domain protein 1	Homo sapiens	50-59
11507908-3	2001	The radicals CCl3 and CHCl2 were able to react with O2 to form CCl3O2 and CHCl2O2 respectively, or to form C2Cl6 and C2H2Cl4 without O2.	Oxygen	67-69	C-C motif chemokine ligand 3	Homo sapiens	13-17
27981581-0	2017	Dissecting neurovascular coupling mechanisms: a role for adenosine A2A receptor: An Editorial highlight for "Correlation of transient adenosine release and oxygen changes in the caudate-putamen".	Oxygen	156-162	adenosine A2a receptor	Homo sapiens	57-79
11295442-7	2001	It is shown that a different distance from Trp14 to haem iron in the three proteins might be the structural basis for the different yield of the peroxyl radical and the different efficiency of incorporation of molecular oxygen into styrene.	Oxygen	220-226	thioredoxin domain containing 17	Homo sapiens	43-48
29386753-5	2017	Cellular bioenergetics analysis showed lower cellular oxygen consumption rates in the Lysm HIF1alpha lsl mice.	Oxygen	54-60	hypoxia inducible factor 1, alpha subunit	Mus musculus	91-100
11550088-1	2001	It has been shown that oxygen deprivation results in apoptotic cell death, and that hypoxia inducible factor 1 (HIF1) and the tumor suppressor p53 play key roles in this process.	Oxygen	23-29	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	143-146
29387292-10	2017	Protein kinase C (PKC) activation mediates HIF-1-induced eNOS synthesis in response to hyperoxia/exercise; thus, mild oxygen through PKC activation stimulates kallistatin-mediated HIF-1 and eNOS synthesis.	Oxygen	118-124	nitric oxide synthase 3, endothelial cell	Mus musculus	190-194
29387292-11	2017	In summary, oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1-eNOS-NO pathway.	Oxygen	169-175	nitric oxide synthase 3, endothelial cell	Mus musculus	199-203
11282321-3	2001	When submaximal exercise was &gt;55% of sea level maximum oxygen uptake (VO2max), 1800 m simulated altitude significantly increased heart rate, blood lactate and perceived exertion of skiers.	Oxygen	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
11292660-8	2001	Tumor-induced angiogenesis may augment the oxygen consumption in tumors resulting in an increased expression of hypoxia-related, proangiogenic genes as well as of HSP27 and P-glycoprotein, which are involved in a multidrug resistance phenotype.	Oxygen	43-49	heat shock protein family B (small) member 1	Homo sapiens	163-168
11292673-0	2001	Myoglobin facilitates oxygen diffusion.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
11401064-3	2001	The results showed that VEGF mRNA abundance was increased three-fold and that of bFGF 1.5-fold when 12% O2+5% CO2 were breathed, but TGF-beta1 did not change.	Oxygen	104-106	vascular endothelial growth factor A	Rattus norvegicus	24-28
28629523-7	2017	These findings suggest that the inhibition of the Epo-EpoR signaling by EMP9 induces the cancer cell death that is mediated by the apoptosis and calcification of the cancer cells as well as the oxygen deficiency through the feeding vessels.	Oxygen	194-200	erythropoietin receptor	Homo sapiens	54-58
11287144-5	2001	Relative activities of two yeast acylCoA:sterol acyltransferases (Are1p and Are2p) changed in response to anaerobiosis: while Are2p was dominant under aerobic conditions, Are1p provided the major activity in the absence of oxygen.	Oxygen	223-229	sterol acyltransferase	Saccharomyces cerevisiae S288C	76-81
11287144-5	2001	Relative activities of two yeast acylCoA:sterol acyltransferases (Are1p and Are2p) changed in response to anaerobiosis: while Are2p was dominant under aerobic conditions, Are1p provided the major activity in the absence of oxygen.	Oxygen	223-229	sterol acyltransferase	Saccharomyces cerevisiae S288C	126-131
11278227-2	2001	High or low oxygen tension was present during the last 16 or 20 h post human chorionic gonadotrophin (HCG)/epidermal growth factor (EGF) addition.	Oxygen	12-18	epidermal growth factor	Homo sapiens	107-130
28024356-4	2016	The focused ultrasound can activate H2O2 to generate more oxygen-contained species (ROS) of stronger oxidation ability than H2O2 for oxidizing LA via the energy transformation from ultrasound mechanical energy to chemical energy, and thus produce more NO for ultimately suppressing the highly aggressive and lethal Panc-1 tumor.	Oxygen	58-64	pancreas protein 1	Mus musculus	315-321
11278227-2	2001	High or low oxygen tension was present during the last 16 or 20 h post human chorionic gonadotrophin (HCG)/epidermal growth factor (EGF) addition.	Oxygen	12-18	epidermal growth factor	Homo sapiens	132-135
11264305-3	2001	Using a combination of extracellular and whole-cell recordings in the CA1 region of hippocampal slices from 12- to 24-d-old rats, we have found that this protective depression of synaptic transmission weakens with repeated exposure to hypoxia, thereby allowing potentially damaging excitation to both persist for longer during oxygen deprivation and recover more rapidly on reoxygenation.	Oxygen	327-333	carbonic anhydrase 1	Rattus norvegicus	70-73
28232898-3	2016	The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit beta (beta-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 alpha chains and 2 beta chains that is responsible for binding to the oxygen in the blood.	Oxygen	299-305	hemoglobin subunit beta	Homo sapiens	65-68
28232898-3	2016	The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit beta (beta-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 alpha chains and 2 beta chains that is responsible for binding to the oxygen in the blood.	Oxygen	299-305	hemoglobin subunit beta	Homo sapiens	87-110
27923829-3	2016	Silencing IKKepsilon in PDAC cells, which overexpressed it endogenously, was sufficient to reduce malignant cell growth, clonogenic potential, glucose consumption, lactate secretion, and expression of genes involved in glucose metabolism, without impacting the basal oxygen consumption rate.	Oxygen	267-273	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	10-20
11300843-13	2001	Analysis of the supramolecular organization at the interface between the cation and anion layers shows that this difference is responsible for the two different BEDT-TTF packing motifs, as a consequence of weak H-bonding interactions between the terminal ethylene groups in the donor and the [M(C(2)O(4))(3)](3-) oxygen atoms.	Oxygen	313-319	ras homolog family member H	Homo sapiens	166-169
27951658-1	2016	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme-containing enzymes that catalyze the O2-dependent oxidation of l-tryptophan (l-Trp) in biological systems.	Oxygen	117-119	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
11351543-4	2001	The dechlorination rate of CCl4 was reduced in the presence of dissolved O2 due to its competition for conduction band electrons.	Oxygen	73-75	C-C motif chemokine ligand 4	Homo sapiens	27-31
27951658-1	2016	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme-containing enzymes that catalyze the O2-dependent oxidation of l-tryptophan (l-Trp) in biological systems.	Oxygen	117-119	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
27798602-4	2016	Here we show that 2-hydroxyglutarate accumulates in mouse CD8+ T cells in response to T-cell receptor triggering, and accumulates to millimolar levels in physiological oxygen conditions through a hypoxia-inducible factor 1-alpha (HIF-1alpha)-dependent mechanism.	Oxygen	168-174	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-228
11238402-4	2001	The first mechanism employs two repression factors, Mox1 and Mox2, and an activation factor, Mox4 (for mannoprotein regulation by oxygen).	Oxygen	130-136	Upc2p	Saccharomyces cerevisiae S288C	93-97
11231633-7	2001	Studies with cultured cortical neurons demonstrated that exogenous purified astrocyte-secreted clusterin exacerbated oxygen/glucose-deprivation-induced necrotic death.	Oxygen	117-123	clusterin	Mus musculus	95-104
27693634-6	2016	In this study, we demonstrated that pVHL inhibits NF-kappaB by mediating K63-ubiquitination of IKKbeta, which is dependent on oxygen.	Oxygen	126-132	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	95-102
28451143-8	2016	The excellent correlation between the ROS production ability and the USP2 inhibition potency emphasizes that the relatively easy, fast, and reliable testing of electrocatalytic oxygen reduction by small molecules might be applied to screening and evaluating new drug candidates for similar targets.	Oxygen	177-183	ubiquitin specific peptidase 2	Homo sapiens	69-73
11053410-10	2001	Together, these data indicate that the reaction of wild-type human Mb and NO yields either heme-NO or a novel S-nitrosated protein dependent on the oxidation state of the heme iron and the presence or absence of dioxygen.	Oxygen	212-220	myoglobin	Homo sapiens	67-69
11216967-8	2001	4) Monocyte chemoattractant protein-1 enhanced the generation of O2- in monocytes from unstable angina patients, and the antioxidant glutathione-monoethyl ester suppressed the production of IL-8 and MCP-1 in these cells.	Oxygen	65-67	C-C motif chemokine ligand 2	Homo sapiens	3-37
27770661-1	2016	We know that silencing Bim, a pro-apoptosis protein, significantly attenuates glucose and oxygen-deprived induced apoptosis in cardiomyocytes.	Oxygen	90-96	Bcl2-like 11	Rattus norvegicus	23-26
11160238-2	2001	Compared with WT mice, increased levels of O(2)(-), NO, and the more highly reactive ONOO(-) were detected in the liver and produced by lesional cells isolated from liver granulomas of infected IL-4(-/-) mice.	Oxygen	43-47	interleukin 4	Mus musculus	194-198
11160238-8	2001	Taken together, these data indicate that IL-4 is playing a protective role during schistosomiasis by controlling the tight regulation of the generation of reactive oxygen and nitrogen intermediates in the liver.	Oxygen	164-170	interleukin 4	Mus musculus	41-45
11240337-0	2001	Relation of plasma leptin concentrations to sex, body fat, dietary intake, and peak oxygen uptake in young adult women and men.	Oxygen	84-90	leptin	Homo sapiens	19-25
11121799-0	2001	Potential role of eNOS in the therapeutic control of myocardial oxygen consumption by ACE inhibitors and amlodipine.	Oxygen	64-70	nitric oxide synthase 3, endothelial cell	Mus musculus	18-22
12624301-5	2003	METHODS: HI was induced in 7-day-old CD1 mice by exposure to 8% oxygen for 30 minutes after occlusion of the left common carotid artery.	Oxygen	64-70	CD1 antigen complex	Mus musculus	37-40
12608704-0	2003	Discussion of the role of the extracellular signal-regulated kinase-phospholipase A2 pathway in production of reactive oxygen species in Alzheimer"s disease.	Oxygen	119-125	phospholipase A2 group IB	Rattus norvegicus	68-84
12559387-10	2003	Complexation with cytochrome b(5) enhances the rate of formation of the active oxygen by obviating the need for two interactions with reductase.	Oxygen	79-85	cytochrome b5 type A	Homo sapiens	18-33
11121799-0	2001	Potential role of eNOS in the therapeutic control of myocardial oxygen consumption by ACE inhibitors and amlodipine.	Oxygen	64-70	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	86-89
28139961-3	2016	Expression of genes related to neural differentiation occurred more quickly in PS and/or 2% O2 than in DN and/or 20% O2, resulting in high responsiveness of neural cells to glutamate, N-methyl-d-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and ( S)-3,5-dihydroxyphenylglycine (an agonist for mGluR1/5), as revealed by calcium imaging assays.	Oxygen	92-94	glutamate receptor, metabotropic 1	Mus musculus	326-334
21336918-2	2001	After activation of cellular phospholipases and release of free arachidonic acid, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2).	Oxygen	105-111	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	195-200
12489125-0	2003	Analysis of the hypoxia-induced ADH2 promoter of the respiratory yeast Pichia stipitis reveals a new mechanism for sensing of oxygen limitation in yeast.	Oxygen	126-132	alcohol dehydrogenase ADH2	Saccharomyces cerevisiae S288C	32-36
14562712-1	2003	Protein C (PC) deficiency can cause thrombosis, inhibiting oxygen transport to tissue thus resulting in many complications, including death.	Oxygen	59-65	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	0-9
27744530-7	2016	We constructed a second AdRGD vector that expressed oxygen-dependent degradation (ODD)-caspase 3 under the control of the EGFR promoter; the fusion protein contains a core part of the ODD domain of hypoxia inducible factor-1 alpha (HIF-1alpha) fused to caspase 3.	Oxygen	52-58	caspase 3	Canis lupus familiaris	87-96
15115285-1	2003	Heat shock protein 32 (Hsp32, hemoxygenase-1) is induced by reactive oxygen metabolites (ROM) and degrades heme leading to the formation of antioxidant bilirubin.	Oxygen	33-39	heme oxygenase 1	Homo sapiens	0-21
15115285-1	2003	Heat shock protein 32 (Hsp32, hemoxygenase-1) is induced by reactive oxygen metabolites (ROM) and degrades heme leading to the formation of antioxidant bilirubin.	Oxygen	33-39	heme oxygenase 1	Homo sapiens	23-28
11301205-0	2001	Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons.	Oxygen	87-93	carbonic anhydrase 1	Rattus norvegicus	111-114
11727925-2	2001	Studies have suggested that impairment of the mitochondrial-signalled Apaf/caspase 9 pathway and not the death receptor Fas pathway results in almost complete resistance to apoptotic cell death induced by a low oxygen environment.	Oxygen	211-217	caspase 9	Homo sapiens	75-84
27744530-7	2016	We constructed a second AdRGD vector that expressed oxygen-dependent degradation (ODD)-caspase 3 under the control of the EGFR promoter; the fusion protein contains a core part of the ODD domain of hypoxia inducible factor-1 alpha (HIF-1alpha) fused to caspase 3.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	198-230
27744530-7	2016	We constructed a second AdRGD vector that expressed oxygen-dependent degradation (ODD)-caspase 3 under the control of the EGFR promoter; the fusion protein contains a core part of the ODD domain of hypoxia inducible factor-1 alpha (HIF-1alpha) fused to caspase 3.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	232-242
27744530-7	2016	We constructed a second AdRGD vector that expressed oxygen-dependent degradation (ODD)-caspase 3 under the control of the EGFR promoter; the fusion protein contains a core part of the ODD domain of hypoxia inducible factor-1 alpha (HIF-1alpha) fused to caspase 3.	Oxygen	52-58	caspase 3	Canis lupus familiaris	253-262
11005811-6	2000	At one, entirely encompassed within beta-tubulin, the C2- and C3-oxygen atoms of 2CTC and 3CTC overlapped poorly with those of colchicine and thiocolchicine, but distances from the reactive carbon atoms of the analogs to the sulfur atoms of the cysteine residues were qualitatively consistent with reactivity.	Oxygen	65-71	complement C2	Homo sapiens	54-64
12884377-3	2003	The typical orientation of phenethyl group, which has the hydrogen H-6 syn and close to the oxygen of carbonyl C-4, was observed in (-)-(S)-1-acetyl-3-(phenylethyl)-1,3-imidazolidin-4-one but not in the other four compounds; nevertheless, interpretation of chemical shifts based on the ring current effects correlated with the true configuration of the new stereogenic center at C-2.	Oxygen	92-98	complement C4A (Rodgers blood group)	Homo sapiens	111-114
12884377-3	2003	The typical orientation of phenethyl group, which has the hydrogen H-6 syn and close to the oxygen of carbonyl C-4, was observed in (-)-(S)-1-acetyl-3-(phenylethyl)-1,3-imidazolidin-4-one but not in the other four compounds; nevertheless, interpretation of chemical shifts based on the ring current effects correlated with the true configuration of the new stereogenic center at C-2.	Oxygen	92-98	complement C2	Homo sapiens	379-382
27601586-8	2016	Conditions of hypoxia (2% O2) induced growth arrest in subconfluent CEF and markedly stimulated p20K expression, suggesting that the control of proliferation and gas gene expression is closely linked to limiting oxygen concentrations associated with high cell densities.	Oxygen	26-28	extracellular fatty acid-binding protein	Gallus gallus	96-100
12482987-4	2003	Although this transcription factor is essential for adaptation to low oxygen levels, the mechanisms through which it influences cell cycle arrest, including the degree to which it cooperates with the tumor suppressor protein p53, remain poorly understood.	Oxygen	70-76	transformation related protein 53, pseudogene	Mus musculus	225-228
11114203-0	2000	RbcS suppressor mutations improve the thermal stability and CO2/O2 specificity of rbcL- mutant ribulose-1,5-bisphosphate carboxylase/oxygenase.	Oxygen	61-63	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlamydomonas reinhardtii	82-86
27601586-8	2016	Conditions of hypoxia (2% O2) induced growth arrest in subconfluent CEF and markedly stimulated p20K expression, suggesting that the control of proliferation and gas gene expression is closely linked to limiting oxygen concentrations associated with high cell densities.	Oxygen	212-218	extracellular fatty acid-binding protein	Gallus gallus	96-100
27790664-1	2016	Co2+ ions encapsulated in nitrogen doped graphene were applied as an oxygen evolution catalyst.	Oxygen	69-75	complement C2	Homo sapiens	0-3
11112584-6	2000	The barrier height for 1,2-methyl migration from silicon to oxygen in trimethylsilyl hydroperoxide is 47.9 kcal/mol (MP4//MP2/6-31G).	Oxygen	60-66	tryptase pseudogene 1	Homo sapiens	122-125
11124810-3	2000	Hypoxia-inducible factor-1 (HIF-1), consisting of HIF-1alpha and ARNT subunits, activates many genes involved in the cellular and organismal response to O(2) deprivation.	Oxygen	153-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	65-69
15106467-11	2003	In conclusion we can say that the negative correlation between leptin and energy expenditure, ventilation and maximal oxygen uptake is related to physical performance.	Oxygen	118-124	leptin	Homo sapiens	63-69
12487609-10	2002	Thus, stoichiometric oxidation of 1 by dioxygen produced the 4-coordinate, high spin complex [PhB(CH(2)P(O)Ph(2))(2)(CH(2)PPh(2))]CoI, (4), in which the [PhBP(3)] ligand had undergone a 4-electron oxidation.	Oxygen	39-47	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	130-133
12467877-1	2002	Superfusion with an oxygen and glucose deprived medium (in vitro ischemia) of rat hippocampal CA1 pyramidal neurons in tissue slices produced a rapid depolarization within 5 min and thereafter showed no functional recovery (irreversible membrane dysfunction), even if oxygen and glucose were reintroduced.	Oxygen	20-26	carbonic anhydrase 1	Rattus norvegicus	94-97
12467877-1	2002	Superfusion with an oxygen and glucose deprived medium (in vitro ischemia) of rat hippocampal CA1 pyramidal neurons in tissue slices produced a rapid depolarization within 5 min and thereafter showed no functional recovery (irreversible membrane dysfunction), even if oxygen and glucose were reintroduced.	Oxygen	268-274	carbonic anhydrase 1	Rattus norvegicus	94-97
11153617-3	2000	In septic shock patients, NAC improved the clearance of indocyanine green and the relationship of systemic oxygen consumption to oxygen demand.	Oxygen	107-113	synuclein alpha	Homo sapiens	26-29
27332042-11	2016	Transaldolase-deficient mice showed increased oxygen consumption, depletion of Drp1, activation of mTORC1, and elevated expression of NADH:ubiquinone oxidoreductase core subunit S3 (NDUFS3), a pro-oxidant subunit of ETC complex I, as well as increased production of aCL and anti-beta2 GPI autoantibodies.	Oxygen	46-52	transaldolase 1	Mus musculus	0-13
11153617-3	2000	In septic shock patients, NAC improved the clearance of indocyanine green and the relationship of systemic oxygen consumption to oxygen demand.	Oxygen	129-135	synuclein alpha	Homo sapiens	26-29
11140697-4	2000	Adult mice exposed to greater than 95% oxygen concentrations for 48 to 88 hours had increased whole-lung mRNA levels of Bax and Bcl-X(L), no change in Bak, Bad, or Bcl-2, and decreased levels of Bcl-w and Bfl-1.	Oxygen	39-45	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	205-210
12521155-1	2002	Deep-water oxygen concentrations in the Baltic Sea are influenced by eutrophication, but also by saltwater inflows from the North Sea.	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
12521155-1	2002	Deep-water oxygen concentrations in the Baltic Sea are influenced by eutrophication, but also by saltwater inflows from the North Sea.	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
27697645-5	2016	Moreover, docking studies of all oxepine derivatives at the hH1R indicate that the oxygen and the position of the chlorine in the tricyclic core determines, if the R- or the S-enantiomer is the eutomer.	Oxygen	83-89	histamine receptor H1	Homo sapiens	60-64
12502081-0	2002	A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor.	Oxygen	92-98	sucrase-isomaltase	Homo sapiens	32-49
11100120-4	2000	Rapid activation of Egr-1 in response to oxygen deprivation primes the vasculature for dysfunction manifest during reperfusion.	Oxygen	41-47	early growth response 1	Mus musculus	20-25
28773984-1	2016	The improvement and mechanism of the fatigue resistance of TC21 high-strength titanium alloy with a high velocity oxygen fuel (HVOF) sprayed WC-17Co coating was investigated.	Oxygen	114-120	RAS related 2	Homo sapiens	59-63
11053035-3	2000	We hypothesize that EC-SOD plays a pivotal role in the response to increased oxygen tension and NO in the neonatal lung.	Oxygen	77-83	extracellular superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	20-26
12458176-4	2002	The beta subunit (also termed ARNT, aryl hydrocarbon receptor nuclear translocator) is abundantly expressed in an oxygen-independent manner.	Oxygen	114-120	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	30-34
12458176-4	2002	The beta subunit (also termed ARNT, aryl hydrocarbon receptor nuclear translocator) is abundantly expressed in an oxygen-independent manner.	Oxygen	114-120	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	36-82
12480908-5	2002	Expression of tahA cDNA restored high-affinity iron uptake in a deltaatx1 yeast strain and oxygen sensitivity in a deltasod1 deltasod2 yeast strain, showing that tahA is also a functional homologue of ATX1.	Oxygen	91-97	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	201-205
11074883-1	2000	HYPOTHESIS: Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor (VEGF) levels in wounds.	Oxygen	23-29	vascular endothelial growth factor A	Rattus norvegicus	54-88
27765951-3	2016	This research showed that hPMSCs cultured in hypoxic conditions (5% O2) exhibited a more naive morphology and had a higher proliferative capability and higher HIF-2alpha expression than hPMSCs cultured in normoxic conditions (21% O2).	Oxygen	68-70	endothelial PAS domain protein 1	Homo sapiens	159-169
11074883-1	2000	HYPOTHESIS: Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor (VEGF) levels in wounds.	Oxygen	23-29	vascular endothelial growth factor A	Rattus norvegicus	90-94
11112851-3	2000	The cloned gene comprising the entire open reading frame restores oxygen-dependent regulation of succinate dehydrogenase in an ArcB-deficient E. coli strain.	Oxygen	66-72	hypothetical protein	Escherichia coli	127-131
11112851-8	2000	The involvement of this region in ArcB-mediated oxygen-dependent regulation is suggested.	Oxygen	48-54	hypothetical protein	Escherichia coli	34-38
12456489-2	2002	Using genetically altered mice to enhance or disrupt extracellular superoxide dismutase (EC-SOD, SOD3), we tested the hypothesis that this enzyme plays a critical role in the physiological response to oxygen in the brain by regulating nitric oxide (NO*) availability.	Oxygen	201-207	superoxide dismutase 3, extracellular	Mus musculus	53-87
12456489-2	2002	Using genetically altered mice to enhance or disrupt extracellular superoxide dismutase (EC-SOD, SOD3), we tested the hypothesis that this enzyme plays a critical role in the physiological response to oxygen in the brain by regulating nitric oxide (NO*) availability.	Oxygen	201-207	superoxide dismutase 3, extracellular	Mus musculus	89-95
12456489-3	2002	Cerebral blood flow responses in these genetically altered mice to changes in PO2 demonstrate that SOD3 regulates equilibrium between superoxide (*O2-) and NO*, thereby controlling vascular tone and reactivity in the brain.	Oxygen	79-81	superoxide dismutase 3, extracellular	Mus musculus	99-103
12456489-5	2002	Thus, EC-SOD promotes NO* vasodilation by scavenging *O2- while hyperoxia opposes NO* and promotes constriction by enhancing endogenous *O2- generation and decreasing basal vasodilator effects of NO*.	Oxygen	54-56	superoxide dismutase 3, extracellular	Mus musculus	6-12
27701455-1	2016	INTRODUCTION: The growth factor HBEGF is upregulated post-transcriptionally in the low O2 environment of the human placenta during the first 10 weeks of pregnancy.	Oxygen	87-89	heparin binding EGF like growth factor	Homo sapiens	32-37
12429854-6	2002	This result was based on second-order many-body perturbation (MP2) calculations that showed that strong binding should occur between the oxygen and helium atoms in the assumed singlet ground state.	Oxygen	137-143	tryptase pseudogene 1	Homo sapiens	62-65
12376368-2	2002	In vitro, hypoxia increased VEGF mRNA and protein levels, with maximal stimulation at 0% O2 for 18 h. A similar upregulation of VEGF expression was found in alveolar epithelial type II (ATII) cells freshly isolated from rats exposed to 8% O2 for 24 h. In vitro, hypoxia-induced upregulation of VEGF mRNA was due to an increase in transcription, rather than an increase in RNA stability, inasmuch as the half-life of VEGF mRNA was unchanged.	Oxygen	239-241	vascular endothelial growth factor A	Rattus norvegicus	128-132
12376368-2	2002	In vitro, hypoxia increased VEGF mRNA and protein levels, with maximal stimulation at 0% O2 for 18 h. A similar upregulation of VEGF expression was found in alveolar epithelial type II (ATII) cells freshly isolated from rats exposed to 8% O2 for 24 h. In vitro, hypoxia-induced upregulation of VEGF mRNA was due to an increase in transcription, rather than an increase in RNA stability, inasmuch as the half-life of VEGF mRNA was unchanged.	Oxygen	239-241	vascular endothelial growth factor A	Rattus norvegicus	128-132
12376368-2	2002	In vitro, hypoxia increased VEGF mRNA and protein levels, with maximal stimulation at 0% O2 for 18 h. A similar upregulation of VEGF expression was found in alveolar epithelial type II (ATII) cells freshly isolated from rats exposed to 8% O2 for 24 h. In vitro, hypoxia-induced upregulation of VEGF mRNA was due to an increase in transcription, rather than an increase in RNA stability, inasmuch as the half-life of VEGF mRNA was unchanged.	Oxygen	239-241	vascular endothelial growth factor A	Rattus norvegicus	128-132
11086893-7	2000	From the difference SDF (DSDF), deltagoo(x,y, z), between the SDFs of two conformations, we concluded that the distribution of hydration water molecules in the HA and HD parts of the MIX region are governed by the competition of internal hydrogen bonds between the hydrogen atom and two lone-pair electrons on the oxygen atom of an EG molecule.	Oxygen	314-320	Mix paired-like homeobox	Homo sapiens	183-186
11078341-1	2000	Experiments were carried out in mutant 129/SvEv mice lacking the endothelin-A (ET(A))-receptor to determine whether endothelin-1 (ET-1), acting as a messenger for oxygen constriction, is responsible for closure of the ductus arteriosus at birth.	Oxygen	163-169	endothelin 1	Mus musculus	130-134
11078341-6	2000	We conclude that ET-1 mediates the ductus constriction to oxygen.	Oxygen	58-64	endothelin 1	Mus musculus	17-21
11097477-11	2000	CONCLUSIONS: Our observations suggest that differences in oxygen levels across the hepatic parenchyma could participate in the zonated expression of ASL.	Oxygen	58-64	argininosuccinate lyase	Rattus norvegicus	149-152
27701455-2	2016	We have examined the possible roles of HBEGF turnover and micro-RNA (miRNA) in its regulation by O2 in human first trimester trophoblast.	Oxygen	97-99	heparin binding EGF like growth factor	Homo sapiens	39-44
11034849-2	2000	The molecule was produced by reacting oxygen atoms, produced in a microwave discharge containing an O(2)/He mixture, with BCl(3).	Oxygen	38-44	BCL3 transcription coactivator	Homo sapiens	122-128
12470895-6	2002	The daf-16 phenotype resembles that of mev-1 showing a short life and oxygen sensitivity.	Oxygen	70-76	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	4-10
27701455-8	2016	RESULTS: Protein turnover studies, using 10 mug/ml cyclohexamide, 1 mug/ml lactocystin, or 100 mug/ml MG132, demonstrated faster HBEGF degradation at 20% O2 than 2% O2, mediated by the proteasome.	Oxygen	154-156	heparin binding EGF like growth factor	Homo sapiens	129-134
11034849-2	2000	The molecule was produced by reacting oxygen atoms, produced in a microwave discharge containing an O(2)/He mixture, with BCl(3).	Oxygen	100-104	BCL3 transcription coactivator	Homo sapiens	122-128
27701455-8	2016	RESULTS: Protein turnover studies, using 10 mug/ml cyclohexamide, 1 mug/ml lactocystin, or 100 mug/ml MG132, demonstrated faster HBEGF degradation at 20% O2 than 2% O2, mediated by the proteasome.	Oxygen	165-167	heparin binding EGF like growth factor	Homo sapiens	129-134
27701455-12	2016	Nevertheless, HBEGF upregulation at 2% O2 was blocked when the miRNA-processing protein DGCR8 was silenced, suggesting a role for miRNA.	Oxygen	39-41	heparin binding EGF like growth factor	Homo sapiens	14-19
12381195-8	2002	Cross-linked myoglobin-polyion films on pyrolytic graphite electrodes were used in strongly acidic solutions for the electrochemical catalytic reduction of trichloracetic acid, hydrogen peroxide, and oxygen.	Oxygen	200-206	myoglobin	Homo sapiens	13-22
11083573-14	2000	Histopathologic examination of the dissected grafts demonstrated a significantly better integrity of the fat tissue in the group that received hyperbaric oxygen for 5 days (p = 0.047).	Oxygen	154-160	CD36 molecule	Mus musculus	105-108
27497816-4	2016	Using a 4T1 breast cancer model, we show that in vivo administration of PX-478, an inhibitor of oxygen-sensitive HIF-1alpha, led to reduced expression of Foxp3 and VEGF transcript and/or protein, molecules that are directly controlled by HIF-1.	Oxygen	96-102	hypoxia inducible factor 1, alpha subunit	Mus musculus	113-123
11083573-17	2000	An inverse correlation was found between an increased dose of the high-pressure oxygen and fat tissue integrity (r = -0.87, p = 0.076).	Oxygen	80-86	CD36 molecule	Mus musculus	91-94
11083573-18	2000	The toxic effects of highly reactive oxygen species on fat cells might explain the failure of an excessively high dose of hyperbaric oxygen to provide any beneficial outcome.	Oxygen	37-43	CD36 molecule	Mus musculus	55-58
12145295-9	2002	Because extravesicular, cytoplasmic dopamine can be easily oxidized into reactive oxygen species and other toxic metabolites, mutations in alpha-synuclein might lead to Parkinson"s disease by triggering protracted, low grade dopamine toxicity resulting in terminal degeneration and ultimately cell death.	Oxygen	82-88	synuclein alpha	Homo sapiens	139-154
27497816-4	2016	Using a 4T1 breast cancer model, we show that in vivo administration of PX-478, an inhibitor of oxygen-sensitive HIF-1alpha, led to reduced expression of Foxp3 and VEGF transcript and/or protein, molecules that are directly controlled by HIF-1.	Oxygen	96-102	forkhead box P3	Mus musculus	154-159
11390925-0	2000	Myoglobin: Just an Oxygen Store or Also an Oxygen Transporter?	Oxygen	19-25	myoglobin	Homo sapiens	0-9
11390925-1	2000	Besides acting as an oxygen store during times of reduced blood oxygen supply, myoglobin can also facilitate intracellular oxygen transport by diffusion of oxymyoglobin along a PO(2) gradient.	Oxygen	21-27	myoglobin	Homo sapiens	79-88
27082941-1	2016	The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing.	Oxygen	9-15	egl-9 family hypoxia-inducible factor 1	Mus musculus	23-74
11390925-1	2000	Besides acting as an oxygen store during times of reduced blood oxygen supply, myoglobin can also facilitate intracellular oxygen transport by diffusion of oxymyoglobin along a PO(2) gradient.	Oxygen	64-70	myoglobin	Homo sapiens	79-88
11390925-1	2000	Besides acting as an oxygen store during times of reduced blood oxygen supply, myoglobin can also facilitate intracellular oxygen transport by diffusion of oxymyoglobin along a PO(2) gradient.	Oxygen	64-70	myoglobin	Homo sapiens	79-88
11390925-2	2000	We reassess the importance of myoglobin-facilitated oxygen diffusion by applying new findings on the intracellular diffusivity of myoglobin in a model calculation.	Oxygen	52-58	myoglobin	Homo sapiens	30-39
11390925-2	2000	We reassess the importance of myoglobin-facilitated oxygen diffusion by applying new findings on the intracellular diffusivity of myoglobin in a model calculation.	Oxygen	52-58	myoglobin	Homo sapiens	130-139
10995435-10	2000	Both the maximal rate of ADP-stimulated oxygen consumption and the dissociation constant (K(m)) for ADP are significantly reduced in desmin-null cardiac and soleus muscle compared with controls.	Oxygen	40-46	desmin	Mus musculus	133-139
10962034-1	2000	Compared with free heme, the proteins hemoglobin (Hb) and myoglobin (Mb) exhibit greatly enhanced affinity for oxygen relative to carbon monoxide.	Oxygen	111-117	myoglobin	Homo sapiens	58-67
10988175-8	2000	Serum leptin levels correlated positively with BMI, skinfold thickness, serum cholesterol, low-density lipoprotein cholesterol, insulin, insulin/glucose ratio, apnea-hypopnea index, and oxygen desaturation time; multiple stepwise regression analysis identified skinfold thickness, waist/hip ratio, serum low-density lipoprotein cholesterol, and diastolic BP as independent correlates, while only serum insulin and diastolic BP were independent correlates in OSA subjects.	Oxygen	186-192	leptin	Homo sapiens	6-12
10985975-5	2000	Secretion of CRH into the maternal and fetal placental circulations was measured during changes in oxygen tension in normal placentae and placentae from abnormal pregnancies complicated by pre-eclampsia.	Oxygen	99-105	corticotropin releasing hormone	Homo sapiens	13-16
10985975-7	2000	During high oxygen perfusion, CRH (0.	Oxygen	12-18	corticotropin releasing hormone	Homo sapiens	30-33
10985975-9	2000	However, during low oxygen perfusion, the vasodilatory effects of CRH were completely inhibited (P&lt;/= 0.05, regression analysis, ANOVA).	Oxygen	20-26	corticotropin releasing hormone	Homo sapiens	66-69
10985975-12	2000	Low oxygen perfusion was associated with an increase in CRH secretion into the maternal but not fetal circulation.	Oxygen	4-10	corticotropin releasing hormone	Homo sapiens	56-59
10985975-14	2000	In conclusion CRH-induced vasodilatation of the fetal placental vasculature in vitro is inhibited during low oxygen perfusion.	Oxygen	109-115	corticotropin releasing hormone	Homo sapiens	14-17
10926859-0	2000	Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem.	Oxygen	0-6	AAA family ATPase peroxin 1	Saccharomyces cerevisiae S288C	97-102
10926859-0	2000	Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem.	Oxygen	178-184	AAA family ATPase peroxin 1	Saccharomyces cerevisiae S288C	97-102
10931059-6	2000	The preoperative forced expiratory volume, arterial partial pressure of oxygen and the aminopyrine breath test showed more severely compromised pulmonary and hepatic function in patients with an SCC (P &lt; 0.05 for all variables).	Oxygen	72-78	serpin family B member 3	Homo sapiens	195-198
10922063-3	2000	HIF-1alpha, and its relatives HIF-2alpha/endothelial PAS domain protein (EPAS) and HIF-3alpha, are induced in response to hypoxia and serve to coordinately activate the expression of target genes whose products facilitate cell survival under conditions of oxygen deprivation.	Oxygen	256-262	endothelial PAS domain protein 1	Homo sapiens	30-40
10924691-1	2000	The hypothesis that NAD(P)H oxidase may serve as an oxygen sensor was tested using the mice deficient (knock-out) in gp91phox subunit of NAD(P)H oxidase enzyme complex and compared with wild-type (C57BL/6J) strain measuring the ventilatory and glomus cell intracellular calcium ([Ca(2+)](i)) responses of carotid body to hypoxia.	Oxygen	52-58	paired Ig-like receptor B	Mus musculus	117-121
10860758-0	2000	Canine coronary microvessel NO production regulates oxygen consumption in ecNOS knockout mouse heart.	Oxygen	52-58	nitric oxide synthase 3, endothelial cell	Mus musculus	74-79
10864977-1	2000	PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature.	Oxygen	97-103	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	10-14
10873592-3	2000	ARNT2 is a conserved ARNT homolog that is highly expressed in neurons, suggesting that ARNT2/HIF-1alpha heterodimers mediate transcriptional responses to oxygen deprivation in the nervous system.	Oxygen	154-160	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	0-5
10873592-3	2000	ARNT2 is a conserved ARNT homolog that is highly expressed in neurons, suggesting that ARNT2/HIF-1alpha heterodimers mediate transcriptional responses to oxygen deprivation in the nervous system.	Oxygen	154-160	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
10873592-3	2000	ARNT2 is a conserved ARNT homolog that is highly expressed in neurons, suggesting that ARNT2/HIF-1alpha heterodimers mediate transcriptional responses to oxygen deprivation in the nervous system.	Oxygen	154-160	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	87-92
10856212-1	2000	Plant production in the sea is a primary mechanism of global oxygen formation and carbon fixation.	Oxygen	61-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
10899353-0	2000	Singlet oxygen ((1)O2) inactivates plasmatic free and complexed alpha2-macroglobulin.	Oxygen	16-21	alpha-2-macroglobulin	Homo sapiens	64-84
10843633-6	2000	The most favorable pathway takes place along an endo/syn approach of the furan ring relative to the bridged oxygen atom of the oxanorbornadiene system, with participation of the substituted double bond.	Oxygen	108-114	mannosidase endo-alpha	Homo sapiens	48-52
10827006-0	2000	The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner.	Oxygen	56-62	erythropoietin	Mus musculus	21-35
10788478-10	2000	These results indicate that intracellular interaction of thiols with NO is an important determinant in the mechanism leading to HO-1 induction by reduced oxygen levels.	Oxygen	154-160	heme oxygenase 1	Homo sapiens	128-132
10819979-8	2000	Based on UV-vis absorption spectra, exposure of the reduced (colorless, presumably diferrous) DcrH-Hr to air resulted in formation of an O(2) adduct also very similar to that of Hr.	Oxygen	137-141	dcrH	Desulfovibrio vulgaris str. Hildenborough	94-98
10819979-11	2000	Given the air-sensitive nature of D. vulgaris and the putative chemotactic function of DcrH, one possible role for the Hr-like domain of DcrH is O(2)-sensing.	Oxygen	145-149	dcrH	Desulfovibrio vulgaris str. Hildenborough	137-141
10737937-5	2000	They have very low oxygen affinity with Pm near 100 mmHg (XL-Peak-1) and near 70 mmHg (XL-Peak-2) respectively at 37 degrees C, at neutral pH.	Oxygen	19-25	pseudopodium enriched atypical kinase 1	Bos taurus	61-67
10766820-3	2000	Such tissue factor expression in an oxygen deficient environment is driven by the transcription factor Early Growth Response (Egr)-1.	Oxygen	36-42	early growth response 1	Mus musculus	103-132
10766820-4	2000	Using homozygous null mice for the protein kinase C beta-isoform gene (PKCbeta null), PKCbeta is shown to be upstream of Egr-1 in this oxygen deprivation-mediated pathway for triggering procoagulant events.	Oxygen	135-141	early growth response 1	Mus musculus	121-126
10766820-7	2000	These data firmly establish PKCbeta as a trigger for events leading to induction of Egr-1 and tissue factor under hypoxic conditions, and provide insight into a biologic cascade whereby oxygen deprivation recruits targets of PKCbeta and Egr-1, thereby amplifying the cellular response.	Oxygen	186-192	early growth response 1	Mus musculus	237-242
10781820-3	2000	Furthermore, the apoptosis induced by C(2)-ceramide and H(2)O(2) was blocked by anti-oxidants, indicating that the ATM(-/-) DT40 cells had a heightened susceptibility to apoptosis induced by reactive oxygen intermediates (ROI), presumably due to defective ROI-detoxification activities.	Oxygen	200-206	ATM serine/threonine kinase	Homo sapiens	115-118
11873750-3	2000	Therapies used to reduce PVR in the cardiac catheterization laboratory include high-flow oxygen; sublingual nitroglycerin; and intravenous inotropic agents, vasodilators, and selective pulmonary vasodilators.	Oxygen	89-95	PVR cell adhesion molecule	Homo sapiens	25-28
11258585-1	2000	During acclimatization to moderate altitudes, a simple calculation from data of others shows that the rise in cerebral blood flow (CBF) is sufficient that oxygen delivery to brain (DaO2) is constant as arterial oxygen content (CaO2) falls.	Oxygen	155-161	amine oxidase copper containing 2	Homo sapiens	181-185
10745077-9	2000	The corresponding carbonyl oxygen in caspase-9, together with other expected features of the catalytic apparatus, appears in our model.	Oxygen	27-33	caspase 9	Homo sapiens	37-46
10724176-1	2000	Myoglobin, a small globular haem protein that binds gaseous ligands such as O2, CO and NO reversibly at the haem iron, serves as a model for studying structural and dynamic aspects of protein reactions.	Oxygen	76-78	myoglobin	Homo sapiens	0-9
12133841-4	2002	These interactions are (i) electrostatic interactions between the extremity of Lys(25) side chain and carbonyl oxygen atoms of residues from the channel selectivity filter that may be strengthened by solvent exclusion provided by (ii) hydrophobic interactions involving BgK residues Tyr(26) and Phe(6) and Kv1.1 residue Tyr(379) whose side chain protrudes in the channel vestibule.	Oxygen	111-117	potassium voltage-gated channel subfamily A member 1	Homo sapiens	306-311
12364388-3	2002	Guinea pig ventricular myocytes were dialyzed with catalase, which specifically catalyzes the conversion of H2O2 to H2O and oxygen, and then I(Ca-L) was recorded during exposure to isoproterenol (Iso).	Oxygen	124-130	catalase	Cavia porcellus	51-59
12239150-5	2002	Here we describe an oxygen-regulated gene therapy approach to treating homozygous erythropoietin-SV40 T antigen (Epo-TAg(h)) mice with relative erythropoietin deficiency.	Oxygen	20-26	erythropoietin	Mus musculus	82-96
12239150-5	2002	Here we describe an oxygen-regulated gene therapy approach to treating homozygous erythropoietin-SV40 T antigen (Epo-TAg(h)) mice with relative erythropoietin deficiency.	Oxygen	20-26	erythropoietin	Mus musculus	113-116
12239150-5	2002	Here we describe an oxygen-regulated gene therapy approach to treating homozygous erythropoietin-SV40 T antigen (Epo-TAg(h)) mice with relative erythropoietin deficiency.	Oxygen	20-26	erythropoietin	Mus musculus	144-158
12364476-0	2002	Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications.	Oxygen	0-6	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	31-38
12364476-12	2002	The ability of O(2) to regulate 11 beta-HSD2 was determined both in cultures of villous explant from early gestation and in term trophoblast cells after incubation under 3% or 20% O(2).	Oxygen	15-19	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	32-44
12207919-4	2002	Investigation of its ability to support O(2)(-)-generation in cell-free reconstitution experiments combining with neutrophil cytochrome b(558) showed O(2)(-)-generation, provided that recombinant p47(phox) was added.	Oxygen	150-154	pleckstrin	Homo sapiens	196-199
12197721-3	2002	Both isomers undergo rearrangement with intramolecular chelation of the carbonyl oxygen at a boron site, thereby opening the cluster and generating arachno-2,3,-mu(C)-5-eta1(O)-Me{C(O)OMe}C-1,2-(Cp*Ru)2B3H7.	Oxygen	81-87	secreted phosphoprotein 1	Homo sapiens	169-173
12181113-1	2002	In isolated single cardiomyocytes with moderately elevated mitochondrial respiration, direct evidence for intracellular radial gradients of oxygen concentration was obtained by subcellular spectrophotometry of myoglobin (Mb).	Oxygen	140-146	myoglobin	Homo sapiens	210-219
12208766-4	2002	Stable transfection of human breast carcinoma MCF-7 cells with human Trx-1 caused a significant increase in HIF-1alpha protein levels under both normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	159-165	thioredoxin	Homo sapiens	69-74
12208766-4	2002	Stable transfection of human breast carcinoma MCF-7 cells with human Trx-1 caused a significant increase in HIF-1alpha protein levels under both normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	183-189	thioredoxin	Homo sapiens	69-74
12429206-6	2002	Our data suggest an important role for glutathione peroxidase-1 in modulating molecular pathways involved in both the level of cell death and inflammatory cascades in brain through its antioxidant capacity in regulating levels of oxygen species such as hydrogen peroxide.	Oxygen	230-236	glutathione peroxidase 1	Mus musculus	39-63
12440252-0	2002	Hyperbaric oxygen at the Dead Sea.	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	30-33
12423560-6	2002	GMP-140, GPIIb/IIIa and D-dimer were correlated positively with AHI, and negatively with minimal oxygen saturation, P &lt; 0.001.	Oxygen	97-103	selectin P	Homo sapiens	0-7
12175241-3	2002	It was constructed anticipating an intramolecular displacement of the carbon (C17)-oxygen (O4) bond (see product 48).	Oxygen	83-89	cytokine like 1	Homo sapiens	78-81
12163023-8	2002	Thus, PH-4 might be related to cellular oxygen sensing.	Oxygen	40-46	prolyl 4-hydroxylase, transmembrane	Homo sapiens	6-10
12136135-2	2002	Metal-free S100A3, a cysteine-rich Ca(2+)- and Zn(2+)-binding protein, has been crystallized by vapour diffusion under the strict exclusion of oxygen and in the absence of divalent metal ions.	Oxygen	143-149	S100 calcium binding protein A3	Homo sapiens	11-17
12121863-1	2002	Exposure to chronic hypoxia induces erythropoietin (EPO) production to facilitate oxygen delivery to hypoxic tissues.	Oxygen	82-88	erythropoietin	Rattus norvegicus	36-50
12121863-1	2002	Exposure to chronic hypoxia induces erythropoietin (EPO) production to facilitate oxygen delivery to hypoxic tissues.	Oxygen	82-88	erythropoietin	Rattus norvegicus	52-55
12230871-4	2002	HO-1 cleaves the porphyrin macrocycle of heme at the expense of molecular oxygen to release a linear tetrapyrrole biliverdin, carbon monoxide, and ferrous iron; biliverdin is rapidly reduced to bilirubin.	Oxygen	74-80	heme oxygenase 1	Homo sapiens	0-4
12119232-2	2002	Previous studies have shown that toxic oxygen-derived species damage DNA and this damage is recognized and repaired by either human enzyme 8-oxoguanine DNA glycosylase (hOgg1) or Escherichia coli enzyme formamidopyrimidine DNA glycosylase (Fpg).	Oxygen	39-45	8-oxoguanine DNA glycosylase	Homo sapiens	169-174
12118739-1	2002	BACKGROUND: Cerebral oxygen saturation (ScO2) can be assessed by near-infrared spectroscopy.	Oxygen	21-27	synthesis of cytochrome C oxidase 2	Homo sapiens	40-44
12059242-1	2002	The magnitude of the stabilizing interaction between an aliphatic C[bond]H bond attached to an ammonium nitrogen and a carbonyl oxygen was evaluated by ab initio calculations at the MP2/6-311++G** level of theory.	Oxygen	128-134	tryptase pseudogene 1	Homo sapiens	182-185
12111100-2	2002	These governing equations take account of: (i) the non-linear reactions between oxygen and haemoglobin in blood and between oxygen and myoglobin in tissue; (ii) diffusion of oxygen in both the axial and radial directions; and (iii) convection of haemoglobin and plasma in the capillary.	Oxygen	124-130	myoglobin	Homo sapiens	135-144
12111100-2	2002	These governing equations take account of: (i) the non-linear reactions between oxygen and haemoglobin in blood and between oxygen and myoglobin in tissue; (ii) diffusion of oxygen in both the axial and radial directions; and (iii) convection of haemoglobin and plasma in the capillary.	Oxygen	124-130	myoglobin	Homo sapiens	135-144
12120950-3	2002	For this purpose, 9-cis,11-trans CLA methyl ester was autoxidized in the presence of alpha-tocopherol under atmospheric oxygen at 40 degrees C in the dark.	Oxygen	120-126	selectin P ligand	Homo sapiens	33-36
11983854-3	2002	The upstream component, E10R, belongs to the ERV1/ALR family of FAD-containing sulfhydryl oxidases that use oxygen as the electron acceptor.	Oxygen	108-114	growth factor, augmenter of liver regeneration	Homo sapiens	45-49
11983854-3	2002	The upstream component, E10R, belongs to the ERV1/ALR family of FAD-containing sulfhydryl oxidases that use oxygen as the electron acceptor.	Oxygen	108-114	growth factor, augmenter of liver regeneration	Homo sapiens	50-53
12011461-1	2002	Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels.	Oxygen	204-210	endothelial PAS domain protein 1	Homo sapiens	127-138
11864982-3	2002	Three subunits (CcoN, CcoO, and CcoP) comprise the catalytic "core" complex required for the reduction of O(2) and the oxidation of a c-type cytochrome.	Oxygen	106-110	cytochrome-c oxidase, cbb3-type subunit III	Rhodobacter sphaeroides 2.4.1	32-36
12168828-3	2002	MATERIALS AND METHODS: GP"s effects on O2 consumption/CO2 production of PC3 cells were studied using the Micro-Oxymax respirometer.	Oxygen	39-41	chromobox 8	Homo sapiens	72-75
12168828-9	2002	CONCLUSION: The inhibitory action of GP on O2 consumption/CO2 production of PC3 cells may be due to disruption of oxidative phosphorylation by inhibition of mitochondrial succinic dehydrogenase.	Oxygen	43-45	chromobox 8	Homo sapiens	76-79
11978488-6	2002	AAPH thermally decomposes to yield tert-amidinopropane radicals (t-AP(*)) that readily react with oxygen to form peroxyl radicals (t-APOO(*)).	Oxygen	98-104	apolipoprotein O	Homo sapiens	133-137
11988622-3	2002	METHODS: HI was induced in 7-day-old CD1 mice by exposure to 8% oxygen for 30 minutes after occlusion of the left common carotid artery.	Oxygen	64-70	CD1 antigen complex	Mus musculus	37-40
11920687-5	2002	In mice with oxygen-induced ischemic retinopathy, deficiency of eNOS, but not iNOS or nNOS caused a significant decrease in retinal neovascularization and decreased expression of VEGF.	Oxygen	13-19	nitric oxide synthase 3, endothelial cell	Mus musculus	64-68
11867392-0	2002	The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices.	Oxygen	67-73	carbonic anhydrase 1	Rattus norvegicus	101-104
11867392-2	2002	We compared the effects of two commonly used IV anesthetics, thiopental and propofol, on hippocampal CA1 pyramidal cell swelling induced by oxygen/glucose deprivation (OGD) in vitro.	Oxygen	140-146	carbonic anhydrase 1	Rattus norvegicus	101-104
10760151-3	2000	BPI-derived peptide P2 rapidly halted oxygen consumption by stationary-phase cells preincubated with glucose, pyruvate or malate and caused a 109-fold drop in cell viability within 90 min of addition.	Oxygen	38-44	bactericidal permeability increasing protein	Homo sapiens	0-3
10657690-4	2000	In addition, the hypothesis that treatment with the oxygen free radical scavenging enzymes superoxide dismutase and catalase would enhance postasphyxia recovery of evoked potentials and ameliorate pathologic injury was tested.	Oxygen	52-58	catalase	Ovis aries	116-124
10698080-6	2000	However, CA1 neurons are spared if SD is suppressed by reducing the temperature to 35 degrees C during O2/glucose deprivation.	Oxygen	103-105	carbonic anhydrase 1	Rattus norvegicus	9-12
27082941-1	2016	The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing.	Oxygen	9-15	egl-9 family hypoxia-inducible factor 1	Mus musculus	76-80
26860875-17	2016	GBA1 mutations perturb normal mitochondria functioning by increasing generation of free radical species (ROS) and decreasing adenosine triphosphate (ATP) production, oxygen consumption, and membrane potential.	Oxygen	166-172	glucosylceramidase beta	Homo sapiens	0-4
10678740-3	2000	EPO gene expression was stimulated by normobaric hypoxia (8% O2) or by 0.1% carbon monoxide (CO) inhalation for 4 h each, or by intraperitoneal injection of 60 mg/kg cobaltous chloride (CoCl2) for 6 h. Renal EPO mRNA in wt increased 12-, 40-, and 13-fold over normoxic levels in response to hypoxia, CO and CoCl2 respectively.	Oxygen	61-63	erythropoietin	Mus musculus	0-3
27625068-2	2016	FtMt appears to be preferentially expressed in cell types characterized by high metabolic activity and oxygen consumption, suggesting a role in protecting mitochondria from iron-dependent oxidative damage.	Oxygen	103-109	ferritin mitochondrial	Homo sapiens	0-4
27605497-7	2016	Hypoxia reduced ARSB activity, since molecular oxygen is needed for post-translational modification of ARSB.	Oxygen	47-53	arylsulfatase B	Homo sapiens	16-20
27605497-7	2016	Hypoxia reduced ARSB activity, since molecular oxygen is needed for post-translational modification of ARSB.	Oxygen	47-53	arylsulfatase B	Homo sapiens	103-107
27605497-9	2016	Decline of ARSB, in the presence of oxygen, profoundly reduced the oxygen consumption rate and increased the extracellular acidification rate, indicating preference for aerobic glycolysis.	Oxygen	36-42	arylsulfatase B	Homo sapiens	11-15
27605497-9	2016	Decline of ARSB, in the presence of oxygen, profoundly reduced the oxygen consumption rate and increased the extracellular acidification rate, indicating preference for aerobic glycolysis.	Oxygen	67-73	arylsulfatase B	Homo sapiens	11-15
27353362-4	2016	We propose that these elements couple PTOX with electron flow from NAD(P)H to oxygen, and by analogy to chlororespiration (in chloroplasts) and chromorespiration (in chromoplasts), we suggest that they define a respiratory process in etioplasts that we have termed "etiorespiration".	Oxygen	78-84	Alternative oxidase family protein	Arabidopsis thaliana	38-42
26762696-3	2016	During the ascent, blood oxygen saturation at 3.848 m above sea level was found to be decreased when compared to sea level (P &lt; 0.02).	Oxygen	25-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
27315332-2	2016	In this study, the deposition of zein on oxygen plasma treated glass cover slips significantly enhanced cell spreading and viability.	Oxygen	41-47	zein	Zea mays	33-37
27466183-3	2016	Using a mouse model we show that a transmembrane prolyl 4-hydroxylase (P4H-TM), which participates in the oxygen-dependent regulation of the hypoxia-inducible factor (HIF), is a potential novel candidate gene for AMD.	Oxygen	106-112	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	Mus musculus	35-69
27466183-3	2016	Using a mouse model we show that a transmembrane prolyl 4-hydroxylase (P4H-TM), which participates in the oxygen-dependent regulation of the hypoxia-inducible factor (HIF), is a potential novel candidate gene for AMD.	Oxygen	106-112	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	Mus musculus	71-77
27422629-8	2016	Reoxidation of the complex by oxygen results in oxidation of the Met residues to sulfoxide, being Met1 more susceptible to copper-catalyzed oxidation than Met5.	Oxygen	30-36	granzyme M	Homo sapiens	98-102
27027798-6	2016	Thus, an inflammation and cellular oxygen-sensing mechanism that modulates intracellular retention of a mutant BMP receptor determines, in part, its pathologic activity in FOP.	Oxygen	35-41	bone morphogenetic protein 1	Homo sapiens	111-114
27387268-3	2016	However, in the presence of NO/O2, the 1,2-diaminophenyl group of Ru-1 is transformed into a benzotriazole.	Oxygen	31-33	Scm like with four mbt domains 1	Homo sapiens	66-70
26988816-0	2016	Reduction of Oxygen-Induced CSF Hyperintensity on FLAIR MR Images in Sedated Children: Usefulness of Magnetization-Prepared FLAIR Imaging.	Oxygen	13-19	colony stimulating factor 2	Homo sapiens	28-31
26988816-1	2016	BACKGROUND AND PURPOSE: Oxygen-induced CSF hyperintensity on FLAIR MR imaging is often observed in sedated children.	Oxygen	24-30	colony stimulating factor 2	Homo sapiens	39-42
27266634-0	2016	Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans.	Oxygen	59-65	neurofibromin 1	Mus musculus	0-13
26661154-5	2016	Using oxygen and glucose deprivation, we demonstrated that the knockdown of Npas4 in mouse cortical neurons resulted in increased susceptibility to cell death.	Oxygen	6-12	neuronal PAS domain protein 4	Mus musculus	76-81
27133769-12	2016	Altogether, our results demonstrate that mTOR is critically required for cardiomyocyte growth, viability and oxygen supply in early postnatal myocardium and provide insight into the molecular mechanisms involved in apoptosis of mTOR-depleted cardiomyocytes.	Oxygen	109-115	mechanistic target of rapamycin kinase	Mus musculus	41-45
26940531-12	2016	Two atypical mitochondrial electron transport chain subunits (Ndufa4l2 and Cox4i2) were among the most specifically expressed genes in CB glomus cells, highlighting their potential roles in mitochondria-mediated oxygen sensing.	Oxygen	212-218	cytochrome c oxidase subunit 4I2	Mus musculus	75-81
27432981-7	2016	Environmental isotope and biomarker data suggest that sea surface temperature and nutrient cycling in the paleotropical oceans changed sharply during the latest Katian time, with consequent changes in the extent of the oxygen minimum zone and phytoplankton community composition.	Oxygen	219-225	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
27321837-0	2016	The oxygen isotope composition of San Carlos olivine on the VSMOW2-SLAP2 scale.	Oxygen	4-10	Src like adaptor 2	Homo sapiens	67-72
26938313-0	2016	Interaction of O2 with CH4, CF4, and CCl4 by Molecular Beam Scattering Experiments and Theoretical Calculations.	Oxygen	15-17	C-C motif chemokine ligand 4	Homo sapiens	37-41
11849780-14	2002	One ATM mutation carrier developed Grade 4 soft tissue necrosis after RT and required hyperbaric oxygen.	Oxygen	97-103	ATM serine/threonine kinase	Homo sapiens	4-7
26938313-1	2016	Gas phase collisions of O2 by CH4, CF4, and CCl4 have been investigated with the molecular beam technique by measuring both the integral cross section value, Q, and its dependence on the collision velocity, v. The adopted experimental conditions have been appropriate to resolve the oscillating "glory" pattern, a quantum interference effect controlled by the features of the intermolecular interaction, for all the three case studies.	Oxygen	24-26	C-C motif chemokine ligand 4	Homo sapiens	44-48
26938313-3	2016	The present work demonstrates that while O2-CH4 and O2-CF4 are basically bound through the balance between size (Pauli) repulsion and dispersion attraction, an appreaciable intermolecular bond stabilization by charge transfer is operative in O2-CCl4.	Oxygen	41-43	C-C motif chemokine ligand 4	Homo sapiens	245-249
27410847-4	2016	Thus, the application of Ir1 for monitoring intracellular oxygen levels has been realized successfully.	Oxygen	58-64	nischarin	Homo sapiens	25-28
11853467-3	2002	Y(n) type fragment ions, created after glycosidic bond cleavage with oxygen retention on sugar at the reducing end for permethylated compounds, were observed in the normal and linked-scan mass spectra recorded for alpha(1-2) bonded conjugates of flavonoid di- and tri-glycosides.	Oxygen	69-75	adrenoceptor alpha 1D	Homo sapiens	214-223
26690054-7	2016	Accordingly, HuR knockdown decreased oxygen consumption rate and mitochondrial production of ATP, and increased lactate levels.	Oxygen	37-43	ELAV like RNA binding protein 1	Homo sapiens	13-16
11849394-3	2002	Oxygen tension is an important regulator of erythropoietin production and release, but the effect of reduced renal mass on renal tissue oxygen tensions is currently unknown.	Oxygen	0-6	erythropoietin	Rattus norvegicus	44-58
27347141-7	2016	Instead, radical oxygen species generation was significantly increased in hirsute and ATM inhibitor-treated MCF-7 cells.	Oxygen	17-23	ATM serine/threonine kinase	Homo sapiens	86-89
11849394-9	2002	We suggest that higher oxygen tensions are caused by a decrease in filtration fraction, and that these higher tissue oxygen tensions result in decreased renal erythropoietin production and anemia.	Oxygen	117-123	erythropoietin	Rattus norvegicus	159-173
10625299-10	2000	These findings indicate that reactive oxygen intermediates, the transcription factor Egr-1, and p44/42 MAPK are critical elements in the transcriptional regulation of the SERCA2 gene in response to DOX.	Oxygen	38-44	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	171-177
11883705-8	2002	Hyperpnea with 95% O2-5% CO2, but not with 95% air-5% CO2, gas mixture induced significant increase in t-butyl hydroperoxide-initiated CL counts, which were inhibited by DMTU, catalase, or SOD in vitro.	Oxygen	19-21	catalase	Cavia porcellus	176-184
27446049-1	2016	At the Black Sea chemocline, oxygen- and sulfide-rich waters meet and form a niche for thiotrophic pelagic bacteria.	Oxygen	29-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	13-16
10779729-4	2000	Together with the fact that blood circulation in the gizzard is very low at resting, and might be further limited during activity, we conclude that the higher Mb content in gizzards of herbivorous birds is an adaptation, to allow storage and/or facilitated diffusion of oxygen, during process of high mechanical work required to grind down hard and fibrous vegetable food under the conditions of limited circulatory supply.	Oxygen	270-276	myoglobin	Homo sapiens	159-161
27284992-5	2016	Furthermore, in in vitro (JAR cells) and ex vivo (chorionic villous explants) models of placental hypoxia, SPHK1 mRNA and protein were strongly up-regulated under low oxygen tension (1% 02).	Oxygen	167-173	sphingosine kinase 1	Homo sapiens	107-112
10962643-11	2000	These studies indicated that the stability of the glutamyl interaction is due to the interaction of glutamyl oxygen atoms with the DHFR protein.	Oxygen	109-115	dihydrofolate reductase	Homo sapiens	131-135
11896938-12	2002	The formyl-methionyl-leucyl-phenylalanine (fMLP)-induced proapoptotic reactive oxygen intermediates (ROI) production was significantly higher in DM1 patients.	Oxygen	79-85	immunoglobulin heavy diversity 1-7	Homo sapiens	145-148
11779751-10	2002	Soluble complexes failed to activate unprimed neutrophils but generated a rapid and extensive secretion of reactive oxygen metabolites when the cells were primed with granulocyte-macrophage colony stimulating factor (GM-CSF).	Oxygen	116-122	colony stimulating factor 2	Homo sapiens	167-215
10939276-0	2000	Effects of oxygen on kynurenine-3-monooxygenase activity.	Oxygen	11-17	kynurenine 3-monooxygenase	Homo sapiens	21-47
27053105-6	2016	However, notably missing is an SREBP-1 analog that regulates triacylglycerol and glycerophospholipid homeostasis in response to low oxygen.	Oxygen	132-138	sterol regulatory element binding transcription factor 1	Homo sapiens	31-38
10590028-11	1999	Administration of phospholipids with the active SP-B peptide was sufficient to restore pulmonary function and prevent alveolar capillary leak after oxygen exposure, demonstrating the protective role of SP-B during oxygen-induced lung injury.	Oxygen	148-154	surfactant associated protein B	Mus musculus	48-52
10590028-11	1999	Administration of phospholipids with the active SP-B peptide was sufficient to restore pulmonary function and prevent alveolar capillary leak after oxygen exposure, demonstrating the protective role of SP-B during oxygen-induced lung injury.	Oxygen	214-220	surfactant associated protein B	Mus musculus	48-52
10590028-11	1999	Administration of phospholipids with the active SP-B peptide was sufficient to restore pulmonary function and prevent alveolar capillary leak after oxygen exposure, demonstrating the protective role of SP-B during oxygen-induced lung injury.	Oxygen	214-220	surfactant associated protein B	Mus musculus	202-206
10590029-4	1999	Exposure to 100% oxygen for 72 h resulted in an increase of 55% in plasma GPx activity and an increase of 50% in the amount of E-GPx protein in the plasma.	Oxygen	17-23	glutathione peroxidase 3	Mus musculus	127-132
10564111-9	1999	Incubation of isolated parenchymal cell mitochondria with the purified catalytic subunit of PKA and ATP increased both state 3 rates of oxygen uptake and the respiratory control ratio by approximately 50%.	Oxygen	136-142	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	92-95
11779751-10	2002	Soluble complexes failed to activate unprimed neutrophils but generated a rapid and extensive secretion of reactive oxygen metabolites when the cells were primed with granulocyte-macrophage colony stimulating factor (GM-CSF).	Oxygen	116-122	colony stimulating factor 2	Homo sapiens	217-223
12898880-5	2002	The patient was transferred by plane to the National Center of Hyperbaric Medicine Institute of Sea and Tropical Medicine where she was successfully treated with hyperbaric oxygen therapy.	Oxygen	173-179	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
12797669-11	2002	Hyperbaric oxygen treatment significantly reduced tissue myeloperoxidase activity in acute colitis and decreased plasma carbonyl content in chronic colitis.	Oxygen	11-17	myeloperoxidase	Rattus norvegicus	57-72
12523759-6	2002	The critical point of the oxygen sag curve would shift to the mouth of river under O75 low-flow conditions, and the BOD values in the new channel would also slightly increase.	Oxygen	26-32	S-antigen visual arrestin	Homo sapiens	33-36
10598726-6	1999	The percentage of the predicted peak oxygen consumption based on gender, weight, and age was 39.5%+/-5.5% post-LVAD and 47.7%+/-10.9% post-HTx (p &lt; .005).	Oxygen	37-43	Zic family member 3	Homo sapiens	139-142
11800890-1	2001	Our combined theoretical and experimental investigations have led to the discovery of a new polymorph of titanium dioxide, where titanium is seven-coordinated to oxygen in the orthorhombic OI ( Pbca) structure.	Oxygen	162-168	PBCA	Homo sapiens	194-198
26987588-0	2016	Silencing of S100A4, a metastasis-associated protein, inhibits retinal neovascularization via the downregulation of BDNF in oxygen-induced ischaemic retinopathy.	Oxygen	124-130	brain derived neurotrophic factor	Mus musculus	116-120
11709407-12	2001	The evidence supports the idea that A beta-induced production of reactive oxygen species plays a role in this effect.	Oxygen	74-80	amyloid beta (A4) precursor protein	Mus musculus	36-42
10518673-6	1999	This result can be attributed to the greater permeability of CZ-resin vial to oxygen (79.06 cm(3)-mm/m(2)-24 h-atm) when compared with nitrogen (12 cm(3)-mm/m(2)-24 h-atm).	Oxygen	78-84	ATM serine/threonine kinase	Homo sapiens	111-114
27211491-2	2016	Under ambient conditions, AgO has two nonequivalent Ag1 and Ag2 sites that adopt linear and square planar oxygen environment configuration, respectively, corresponding to Ag mixed-valence states.	Oxygen	106-112	chromosome 11 open reading frame 96	Homo sapiens	60-63
10516167-2	1999	The present study tested the hypothesis that low O(2) tension directly stimulates human VSMC proliferation by inducing them to produce interleukin (IL)-1, a potent autocrine growth factor for human VSMC.	Oxygen	49-53	interleukin 1 alpha	Homo sapiens	135-153
10516167-4	1999	Levels of IL-1alpha and IL-1beta mRNA increased in human VSMC after 24-48 h of incubation in low O(2) compared with levels in normoxic cells and then decreased upon subsequent reoxygenation.	Oxygen	97-101	interleukin 1 alpha	Homo sapiens	10-19
11709413-4	2001	Intracellular myoglobin was found to be only 72% saturated under baseline conditions with an arterial oxygen tension of &gt;600 mmHg at 37 degrees C. Baseline intracellular oxygen tension was 6.3 mmHg.	Oxygen	102-108	myoglobin	Cavia porcellus	14-23
11743740-1	2001	Nitric oxide (NO) has been found to inhibit the copper-responsive yeast transcription factor Ace1 in an oxygen-dependent manner.	Oxygen	104-110	Cup2p	Saccharomyces cerevisiae S288C	93-97
27150457-0	2016	Role Of Hif2alpha Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation.	Oxygen	18-24	endothelial PAS domain protein 1	Homo sapiens	8-17
11726537-1	2001	The key elements of circadian clockwork and oxygen homeostasis are the PAS protein family members PER and CLOCK and hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	44-50	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-147
11726537-1	2001	The key elements of circadian clockwork and oxygen homeostasis are the PAS protein family members PER and CLOCK and hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	44-50	hypoxia inducible factor 1, alpha subunit	Mus musculus	149-159
10484461-0	1999	Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro.	Oxygen	20-26	C-C motif chemokine ligand 2	Homo sapiens	55-60
10484491-7	1999	Leptin administered intracerebroventricularly also failed to alter milk/food intakes of 17-day-old pups but markedly increased oxygen consumption of these older mice.	Oxygen	127-133	leptin	Mus musculus	0-6
11696009-7	2001	Exposure to 100% ambient oxygen showed that aconitase was highly susceptible to undergo oxidative damage and loss of activity under oxidative stress.	Oxygen	25-31	Mitochondrial aconitase 1	Drosophila melanogaster	44-53
27150457-8	2016	Thus, our findings identify a novel molecular link between HIF2alpha and Club cell biology that can be regarded as a new HIF2alpha-dependent mechanism involved in bronchial epithelium adaptation to oxygen fluctuations.	Oxygen	198-204	endothelial PAS domain protein 1	Homo sapiens	59-68
27150457-8	2016	Thus, our findings identify a novel molecular link between HIF2alpha and Club cell biology that can be regarded as a new HIF2alpha-dependent mechanism involved in bronchial epithelium adaptation to oxygen fluctuations.	Oxygen	198-204	endothelial PAS domain protein 1	Homo sapiens	121-130
26976644-2	2016	HIFs are regulated in response to oxygen availability by prolyl-4-hydroxylase domain (PHD) proteins, with PHD2 being the main oxygen sensor that controls HIF activity under normoxia.	Oxygen	126-132	egl-9 family hypoxia-inducible factor 1	Mus musculus	106-110
11690645-6	2001	Maximal expression of a nirK-lacZ fusion in strain USDA110 required simultaneously both low level oxygen conditions and the presence of nitrate.	Oxygen	98-104	nitrite reductase, copper-containing	Bradyrhizobium diazoefficiens USDA 110	24-28
11690645-9	2001	These results suggest that nirK expression depends on the low-oxygen-responsive two-component regulatory system FixLJ and on the Fnr/FixK-like DNA binding protein FixK(2).	Oxygen	62-68	nitrite reductase, copper-containing	Bradyrhizobium diazoefficiens USDA 110	27-31
10479642-2	1999	A pathway is outlined through which diminished levels of oxygen activate the transcription factor early growth response-1 (Egr-1) leading to de novo transcription/translation of tissue factor in mononuclear phagocytes and smooth muscle cells, which eventuates in vascular fibrin deposition.	Oxygen	57-63	early growth response 1	Homo sapiens	98-121
10479642-2	1999	A pathway is outlined through which diminished levels of oxygen activate the transcription factor early growth response-1 (Egr-1) leading to de novo transcription/translation of tissue factor in mononuclear phagocytes and smooth muscle cells, which eventuates in vascular fibrin deposition.	Oxygen	57-63	early growth response 1	Homo sapiens	123-128
10479642-4	1999	These data add a new facet to the biology of thrombosis associated with hypoxemia/stasis and imply that interference with mechanisms causing Egr-1 activation in response to oxygen deprivation might prevent vascular fibrin deposition occurring in ischemia without directly interfering with other pro/anticoagulant pathways.	Oxygen	173-179	early growth response 1	Homo sapiens	141-146
10430608-3	1999	TLR4 expression levels in cardiac myocytes and in coronary microvascular endothelial cells could be enhanced by either LPS or IL-1beta, an effect inhibited by the oxygen radical scavenger PDTC.	Oxygen	163-169	toll like receptor 4	Homo sapiens	0-4
10470848-0	1999	Nucleotide sequence of psbQ gene for 16-kDa protein of oxygen-evolving complex from Arabidopsis thaliana and regulation of its expression.	Oxygen	55-61	photosystem II subunit QA	Arabidopsis thaliana	23-27
10470848-1	1999	The psbQ gene encoding a 16-kDa polypeptide of the oxygen-evolving complex of photosystem II has been isolated from Arabidopsis thaliana and characterized.	Oxygen	51-57	photosystem II subunit QA	Arabidopsis thaliana	4-8
11595384-8	2001	The elimination of the DMPO-*OH adduct was determined to be due to the ability of ceruloplasmin to completely reduce oxygen to water during the oxidation of the ferrous iron.	Oxygen	117-123	ceruloplasmin	Homo sapiens	82-95
11566406-9	2001	Based on the actual amount of dinitrotoluene degradation, nitrite release, NaOH consumption, and oxygen uptake were close to the theoretical stoichiometric coefficients of complete DNT mineralization.	Oxygen	97-103	5', 3'-nucleotidase, cytosolic	Homo sapiens	181-184
27088801-2	2016	Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesis in the kidney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cellular oxygen sensors.	Oxygen	138-144	egl-9 family hypoxia-inducible factor 1	Mus musculus	155-159
11585452-7	2001	Replacement of the C-4 sulfur linkage in 1 with an oxygen atom eliminated one of the two major metabolites for this lead molecule.	Oxygen	51-57	complement C4A (Rodgers blood group)	Homo sapiens	19-22
29446909-0	2016	[Association between G/A - Polymorphism of EPAS1 gene and the maximal level of oxygen consumption in Russian athletes.	Oxygen	79-85	endothelial PAS domain protein 1	Homo sapiens	43-48
11681624-3	2001	The results showed that O2*-/HO* free radical oxidized LDL and Lp(a) led to a dramatic decrease of PAI-1 release but did not affect tPA release, whereas copper oxidation of lipoproteins resulted in an increase in PAI-1 release and a decrease in tPA release.	Oxygen	24-26	serpin family E member 1	Homo sapiens	99-104
11681624-3	2001	The results showed that O2*-/HO* free radical oxidized LDL and Lp(a) led to a dramatic decrease of PAI-1 release but did not affect tPA release, whereas copper oxidation of lipoproteins resulted in an increase in PAI-1 release and a decrease in tPA release.	Oxygen	24-26	serpin family E member 1	Homo sapiens	213-218
11694457-6	2001	The activity of cyclin E-CDK2 complex was found to be decreased in O(2)-exposed cells.	Oxygen	67-71	proliferating cell nuclear antigen	Homo sapiens	16-22
10373419-6	1999	To resolve this controversy, we have prepared a ferric alpha-hydroxyheme-heme oxygenase-1 complex and titrated the complex with O2 under strictly anaerobic conditions.	Oxygen	128-130	heme oxygenase 1	Homo sapiens	73-89
10750596-0	1999	Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts.	Oxygen	92-98	angiotensin I converting enzyme	Canis lupus familiaris	26-55
29446909-1	2016	We studied the interrelations between G/A-polymorphism of EPAS 1 gene(rs1867785) and macimal oxygen consumption  (VO2max) in Russian male athletes.	Oxygen	93-99	endothelial PAS domain protein 1	Homo sapiens	58-64
27207113-5	2016	Our results show more oxygen release in the curved cuticle tip region than in other regions of a cuticle capillary loop, associated with a low of RBC flow speed in the tip region.	Oxygen	22-28	TOR signaling pathway regulator	Homo sapiens	59-62
20654504-6	1999	Slices cultured with 70% oxygen exhibited the highest specific activity of catalase, NADPH cytochrome c reductase and gamma-glutamyl transpeptidase (GGT) as well as the highest levels of intracellular glutathione after 48 or 72 hours of incubation.	Oxygen	25-31	gamma-glutamyltransferase 1	Rattus norvegicus	118-147
20654504-6	1999	Slices cultured with 70% oxygen exhibited the highest specific activity of catalase, NADPH cytochrome c reductase and gamma-glutamyl transpeptidase (GGT) as well as the highest levels of intracellular glutathione after 48 or 72 hours of incubation.	Oxygen	25-31	gamma-glutamyltransferase 1	Rattus norvegicus	149-152
10329601-0	1999	Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice.	Oxygen	77-83	fibroblast growth factor 7	Mus musculus	0-26
10329601-1	1999	Keratinocyte growth factor (KGF) has been used successfully to prevent alveolar damage induced by oxygen exposure in rodents.	Oxygen	98-104	fibroblast growth factor 7	Mus musculus	0-26
10329601-1	1999	Keratinocyte growth factor (KGF) has been used successfully to prevent alveolar damage induced by oxygen exposure in rodents.	Oxygen	98-104	fibroblast growth factor 7	Mus musculus	28-31
10340756-11	1999	Because VEGF is stimulated by hypoxia, its preferential mRNA expression near the epicardium, that is, farthest from the ventricular lumen and the O2 source, fits with the hypothesis that a hypoxic gradient is a driving force in the transmural vascularization process.	Oxygen	146-148	vascular endothelial growth factor A	Rattus norvegicus	8-12
10414402-5	1999	Measurement of Ptc,O2 underestimated arterial oxygen tension (Pa,O2) and this underestimation increased with the level of Pa,O2 (p&lt;0.01).	Oxygen	46-52	ret proto-oncogene	Homo sapiens	15-18
10414402-5	1999	Measurement of Ptc,O2 underestimated arterial oxygen tension (Pa,O2) and this underestimation increased with the level of Pa,O2 (p&lt;0.01).	Oxygen	65-67	ret proto-oncogene	Homo sapiens	15-18
10414402-5	1999	Measurement of Ptc,O2 underestimated arterial oxygen tension (Pa,O2) and this underestimation increased with the level of Pa,O2 (p&lt;0.01).	Oxygen	65-67	ret proto-oncogene	Homo sapiens	15-18
10207038-5	1999	The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo).	Oxygen	140-146	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	14-18
10205152-0	1999	Endogenous endothelial nitric oxide synthase-derived nitric oxide is a physiological regulator of myocardial oxygen consumption.	Oxygen	109-115	nitric oxide synthase 3, endothelial cell	Mus musculus	11-44
10205152-1	1999	Our objective was to determine the precise role of endothelial nitric oxide synthase (eNOS) as a modulator of cardiac O2 consumption and to further examine the role of nitric oxide (NO) in the control of mitochondrial respiration.	Oxygen	118-120	nitric oxide synthase 3, endothelial cell	Mus musculus	51-84
10202154-9	1999	Nuclear translocation of thioredoxin from cytoplasm was observed upon reducing O2 concentrations.	Oxygen	79-81	thioredoxin	Homo sapiens	25-36
10200222-1	1999	Intracellular and single-electrode voltage-clamp recordings were made to investigate the process of membrane dysfunction induced by superfusion with oxygen and glucose-deprived (ischemia-simulating) medium in hippocampal CA1 pyramidal neurons of rat tissue slices.	Oxygen	149-155	carbonic anhydrase 1	Rattus norvegicus	221-224
10097075-2	1999	The hydroxyl group of this residue forms a hydrogen bond with the C-4 oxygen atom of the FMN reaction center of the enzyme [Fox, K. M. &amp; Karplus, P. A.	Oxygen	70-76	complement C4A (Rodgers blood group)	Homo sapiens	66-69
11489845-10	2001	ARE2 requires the HAP1 transcription factor for optimal expression, and both ARE genes are derepressed in a rox1 (repressor of oxygen) mutant genetic background.	Oxygen	127-133	sterol acyltransferase	Saccharomyces cerevisiae S288C	0-4
11489845-10	2001	ARE2 requires the HAP1 transcription factor for optimal expression, and both ARE genes are derepressed in a rox1 (repressor of oxygen) mutant genetic background.	Oxygen	127-133	Hap1p	Saccharomyces cerevisiae S288C	18-22
11390403-1	2001	The role of cytochrome b(559) in photosynthetic oxygen evolution has been investigated in three chloroplast mutants of Chlamydomonas reinhardtii, in which one of the two histidine axial ligands to the heme, provided by the alpha subunit, has been replaced by the residues methionine, tyrosine, and glutamine.	Oxygen	48-54	cytochrome b	Chlamydomonas reinhardtii	12-24
11478797-6	2001	These data represent the first direct verification that hTASK1 is O(2)-sensitive and reinforce the idea that this K(+) channel is key to O(2) sensing in chemoreceptors.	Oxygen	66-70	potassium two pore domain channel subfamily K member 3	Homo sapiens	56-62
11549036-1	2001	Two new yeast strains (SPT1 and SPT2) were isolated and immobilized on glassy carbon electrodes to form microbial biosensors for estimation of biochemical oxygen demand (BOD).	Oxygen	155-161	Hir2p	Saccharomyces cerevisiae S288C	23-27
11506017-9	2001	In addition, stoichiometrically excess oxygen atoms were found on the solid surfaces, and they might play an important role in the mineralization of CCl4, leading to the formation of CO2 and Cl.	Oxygen	39-45	C-C motif chemokine ligand 4	Homo sapiens	149-153
11468361-0	2001	Molecular mimicry of substrate oxygen atoms by water molecules in the beta-amylase active site.	Oxygen	31-37	beta-amylase	Glycine max	70-82
11444837-7	2001	Taken together, these data suggest that the acidic pH and low oxygen tension produced during myocardial ischemia will facilitate myoglobin-catalyzed, peroxyntrite-independent formation of 3-nitrotyrosine.	Oxygen	62-68	myoglobin	Homo sapiens	129-138
11430868-4	2001	Oxygen deprivation depressed the focal responses of CA1 neurons to stratum radiatum volleys.	Oxygen	0-6	carbonic anhydrase 1	Rattus norvegicus	52-55
11529507-5	2001	Under the lowered O2 conditions, we noted a remarkable increase in the percentage of large-sized colonies, activation of cell cycle progression factors, phosphorylation of Akt, and downregulation of the cell cycle inhibitor p27Kip1.	Oxygen	18-20	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	224-231
11408933-11	2001	Other genes identified as a result of the microarray analysis not previously known to change as a result of low oxygen treatment were elongation factor-1alpha, glycyl-tRNA synthetase, and laminin receptor protein-1.	Oxygen	112-118	glycyl-tRNA synthetase 1	Homo sapiens	160-182
11478413-7	2001	Tracheal concentrations of IL-8 and MCP-1 were significantly increased in infants who developed BPD (IL-8: P=0.0001; MCP-1: P&lt;0.001, analysis of variance) and correlated with duration of mechanical ventilation and oxygen treatment.	Oxygen	217-223	C-C motif chemokine ligand 2	Homo sapiens	36-41
11412976-2	2001	The energetic and structural results point to the Ile to Val mutation at residue 523 as the key contributor to COX-2 selectivity; unfavorable steric contact between a sulfonamide oxygen and the delta methyl group of Ile523 destabilizes the complex with COX-1.	Oxygen	179-185	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	253-258
11376688-13	2001	These studies with MTH1-null mutant mice provided an important insight into the role of this nucleotide sanitization enzyme in terms of the spontaneous tumorigenesis as well as mutagenesis caused by the oxygen-induced DNA damage.	Oxygen	203-209	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	19-23
11454037-2	2001	Using organotypic cultures of rat hippocampal slices, we determined whether phospholipase A2 (PLA2) is activated in response to ischemic conditions (OGD; oxygen and glucose deprivation).	Oxygen	154-160	phospholipase A2 group IB	Rattus norvegicus	76-92
11454037-2	2001	Using organotypic cultures of rat hippocampal slices, we determined whether phospholipase A2 (PLA2) is activated in response to ischemic conditions (OGD; oxygen and glucose deprivation).	Oxygen	154-160	phospholipase A2 group IB	Rattus norvegicus	94-98
11384393-1	2001	We report the complete vibrational spectrum of the probe nucleus 57Fe at the oxygen-binding site of the protein myoglobin.	Oxygen	77-83	myoglobin	Homo sapiens	112-121
11323373-5	2001	During TVB, end-tidal oxygen (ETO2) increased rapidly and plateaued by 2.5 min at 86%, 88%, and 88% with 5, 7 and 10 L/min FGF, respectively.	Oxygen	22-28	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	30-34
11401707-1	2001	Saccharomyces cerevisiae CYC1 gene expression has been studied in great detail with regard to the response to oxygen availability and carbon source.	Oxygen	110-116	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	25-29
11401707-2	2001	In the absence of oxygen and the presence of glucose, the CYC1 gene is completely repressed.	Oxygen	18-24	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	58-62
11334714-0	2001	Renomedullary interstitial cells in culture; the osmolality and oxygen tension influence the extracellular amounts of hyaluronan and cellular expression of CD44.	Oxygen	64-70	CD44 molecule (Indian blood group)	Rattus norvegicus	156-160
11300728-5	2001	The cell death-enhancing action of mutant PS1 was associated with increased production of reactive oxygen species and altered calcium regulation, but not with changes of mitochondrial cytochrome c. Our study further emphasizes the pathogenic role of mutant PS1 and may provide the fundamental basis for new efforts to close the gap between studies using neuronal cell lines transfected with mutant PS1, neurons from transgenic animals, and peripheral cells from AD patients.	Oxygen	99-105	presenilin 1	Mus musculus	257-260
11300728-5	2001	The cell death-enhancing action of mutant PS1 was associated with increased production of reactive oxygen species and altered calcium regulation, but not with changes of mitochondrial cytochrome c. Our study further emphasizes the pathogenic role of mutant PS1 and may provide the fundamental basis for new efforts to close the gap between studies using neuronal cell lines transfected with mutant PS1, neurons from transgenic animals, and peripheral cells from AD patients.	Oxygen	99-105	presenilin 1	Mus musculus	257-260
11133990-2	2001	In response to low oxygen levels, autophosphorylated ArcB phosphorylates ArcA, and the resulting phosphorylated ArcA (ArcA-P) functions as a transcriptional regulator of the genes necessary to maintain anaerobic growth.	Oxygen	19-25	hypothetical protein	Escherichia coli	53-57
11207473-13	2001	When two different models of oxygen transport are fitted to patient data, high values of Rdiff or low values of fA2 describe the right shift in the FEO2/SaO2 curve seen in patients with oxygenation problems.	Oxygen	29-35	FA complementation group B	Homo sapiens	112-115
11238725-3	2001	NO production was observed mainly in the CA1 area, and was dependent on the concentration of O(2).	Oxygen	93-97	carbonic anhydrase 1	Rattus norvegicus	41-44
11307923-5	2001	Double product, an indicator of myocardial oxygen consumption, significantly decreased during and after ANP administration at all doses in the CHF(+).	Oxygen	43-49	natriuretic peptide A	Canis lupus familiaris	104-107
11307923-6	2001	These findings indicate that even at low dose, exogenous ANP improves cardiac performance and reduces myocardial oxygen consumption in the CHF(+), and suggest that ANP has beneficial effects in the treatment of dogs with overt congestive heart failure resulting from MR.	Oxygen	113-119	natriuretic peptide A	Canis lupus familiaris	57-60
11224808-9	2001	The decrease in PAI-1 significantly (P &lt; 0.05) correlated with oxygen uptake (VO(2)) during submaximal exercise (r = -0.77).	Oxygen	66-72	serpin family E member 1	Homo sapiens	16-21
21290715-5	2001	In Escherichia coli, for example, they involve the oxygen-sensing activities of Fnr and the ArcA/ArcB system (51).	Oxygen	51-57	hypothetical protein	Escherichia coli	97-101
11361012-8	2001	A decreased rate of SSAO inhibition under N2 atmosphere to that obtained under O2 was produced upon preincubation of enzyme with 2-BEA, suggesting that oxidized intermediate was necessary for its inhibitory activity.	Oxygen	79-81	amine oxidase copper containing 2	Homo sapiens	20-24
11121799-1	2001	OBJECTIVES: Our aim was to investigate the potential therapeutic role of endothelial nitric oxide synthase (eNOS) in the modulation of cardiac O(2) consumption induced by the angiotensin converting enzyme (ACE) inhibitor ramiprilat and amlodipine.	Oxygen	143-147	nitric oxide synthase 3, endothelial cell	Mus musculus	73-106
11121799-1	2001	OBJECTIVES: Our aim was to investigate the potential therapeutic role of endothelial nitric oxide synthase (eNOS) in the modulation of cardiac O(2) consumption induced by the angiotensin converting enzyme (ACE) inhibitor ramiprilat and amlodipine.	Oxygen	143-147	nitric oxide synthase 3, endothelial cell	Mus musculus	108-112
11121799-1	2001	OBJECTIVES: Our aim was to investigate the potential therapeutic role of endothelial nitric oxide synthase (eNOS) in the modulation of cardiac O(2) consumption induced by the angiotensin converting enzyme (ACE) inhibitor ramiprilat and amlodipine.	Oxygen	143-147	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	206-209
11133872-0	2001	Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.	Oxygen	20-26	nitric oxide synthase 3, endothelial cell	Mus musculus	50-54
11497223-6	2001	The suppressive effect of EPA was mediated via the production of reactive oxygen products, because EPA-stimulated H2O2 production and the suppressive effect of EPA was restored by addition of catalase or NAC.	Oxygen	74-80	synuclein alpha	Homo sapiens	204-207
11165512-1	2001	Myoglobin, the monomeric haemoprotein expressed in red muscle, is reported in biochemistry and physiology textbooks to function as an intracellular oxygen carrier and oxygen reservoir.	Oxygen	148-154	myoglobin	Homo sapiens	0-9
10074486-3	1999	Expression of the HIF-1alpha subunit increases exponentially as O2 concentration is decreased.	Oxygen	64-66	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-28
11165512-1	2001	Myoglobin, the monomeric haemoprotein expressed in red muscle, is reported in biochemistry and physiology textbooks to function as an intracellular oxygen carrier and oxygen reservoir.	Oxygen	167-173	myoglobin	Homo sapiens	0-9
27207113-6	2016	Further analysis suggests that in addition to the RBC flow speed, other factors, such as the drop of the partial oxygen pressure in the tip region, drive RBCs to release more oxygen in the tip region.	Oxygen	113-119	TOR signaling pathway regulator	Homo sapiens	136-139
27207113-6	2016	Further analysis suggests that in addition to the RBC flow speed, other factors, such as the drop of the partial oxygen pressure in the tip region, drive RBCs to release more oxygen in the tip region.	Oxygen	113-119	TOR signaling pathway regulator	Homo sapiens	189-192
27207113-6	2016	Further analysis suggests that in addition to the RBC flow speed, other factors, such as the drop of the partial oxygen pressure in the tip region, drive RBCs to release more oxygen in the tip region.	Oxygen	175-181	TOR signaling pathway regulator	Homo sapiens	136-139
16351833-3	2001	The hypoxia-inducible transcription factor HIF-1, a heterodimer consisting of the oxygen-regulated alpha-subunit and the constitutively expressed beta or ARNT-subunit, serves as a master regulator of oxygen-dependent gene expression.	Oxygen	200-206	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	154-158
10072489-1	1999	Pretreatment of pancreatic islets in 95% oxygen culture depletes graft-associated APCs and leads to indefinite allograft acceptance in immunocompetent recipients.	Oxygen	41-47	amyloid P component, serum	Homo sapiens	82-86
27207113-6	2016	Further analysis suggests that in addition to the RBC flow speed, other factors, such as the drop of the partial oxygen pressure in the tip region, drive RBCs to release more oxygen in the tip region.	Oxygen	175-181	TOR signaling pathway regulator	Homo sapiens	189-192
26387536-8	2016	Importantly, pharmacological inhibition of HuR by MS-444 inhibits HuR homodimerization and its cytoplasmic translocation, abrogates hypoxia-induced PIM1 overexpression and markedly enhances PDA cell sensitivity to oxaliplatin and 5-fluorouracil under physiologic low oxygen conditions.	Oxygen	267-273	ELAV like RNA binding protein 1	Homo sapiens	43-46
9935166-3	1999	Compared with culture under 20% O2, culture for up to 24 hr under 1% or 4% O2 resulted in increased cell surface uPAR.	Oxygen	75-77	plasminogen activator, urokinase receptor	Homo sapiens	113-117
9935166-4	1999	However, the highest uPAR levels were observed in cells cultured under 1% O2.	Oxygen	74-76	plasminogen activator, urokinase receptor	Homo sapiens	21-25
10072228-2	1999	The Dead Sea, the lowest site on earth, is distinguished by natural oxygen enrichment, low humidity, high barometric pressure, and temperature with increased bromide and magnesium concentrations in the inspired air.	Oxygen	68-74	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
11188692-8	2000	Gly-60 and Gly-13 may play direct catalytic roles and stabilize the attacking water molecule and beta,gamma-bridging oxygen, respectively, in p21.	Oxygen	117-123	H3 histone pseudogene 16	Homo sapiens	142-145
11154734-1	2000	Epoxides are organic three-membered oxygen compounds that arise from oxidative metabolism of endogenous, as well as xenobiotic compounds via chemical and enzymatic oxidation processes, including the cytochrome P450 monooxygenase system.	Oxygen	36-42	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	199-228
26781224-2	2016	Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids.	Oxygen	323-329	Ras related GTP binding A	Homo sapiens	51-57
11134568-9	2000	CONCLUSION: When cultured at 1-percent O(2) for 7 days in presence of IL-3 and SCF, the CD34+ cells present in apheresis components underwent more cell divisions and better maintained their primitive progenitor cell potential.	Oxygen	39-43	interleukin 3	Homo sapiens	70-74
10499107-3	1999	This 24 kJ/mol energy difference accounts for most of the discrimination between CO and O2 by myoglobin (about 17 kJ/mol).	Oxygen	88-90	myoglobin	Homo sapiens	94-103
26857347-10	2016	Losartan decreased cardiac hypertrophy and fibrosis and improved left ventricle fraction of shortening in P28 O2-exposed rats, which was associated with decreased oxidation of calcium/calmodulin-dependent protein kinase II, inhibition of the transforming growth factor-beta/SMAD3 pathway, and upregulation of cardiac angiotensin-converting enzyme 2.	Oxygen	110-112	golgi SNAP receptor complex member 1	Rattus norvegicus	106-109
21374288-1	1999	Myoglobin represents the stores of oxygen in muscle tissues.	Oxygen	35-41	myoglobin	Homo sapiens	0-9
11332353-6	2000	The positive correlation was found between increased concentration of phospholipase A2 in serum and reduction of partial pressure of oxygen and pH of blood and the degree of severity of respiratory failure.	Oxygen	133-139	phospholipase A2 group IB	Canis lupus familiaris	70-86
26935869-2	2016	The present study aimed to investigate the effects of miR-218, as well as its host genes, Slit2 and Slit3, on oxygen-induced retinal neovascularization (RNV) and to explore the associated mechanisms of action.	Oxygen	110-116	slit guidance ligand 3	Mus musculus	100-105
11027312-5	2000	Oxygen consumption of Mc4r-null mice with similar body weights as WT controls was reduced by 20%.	Oxygen	0-6	melanocortin 4 receptor	Mus musculus	22-26
11032742-8	2000	Using a human thioredoxin in which the structural cysteines were mutated to alanine, Trx-C3A, we show that structural cysteines that do not take part in the catalytic functions of the protein are also important for its reactive oxygen scavenging properties.	Oxygen	228-234	thioredoxin	Homo sapiens	14-25
11024452-5	2000	Veratridine, a Na(+) channel opener that increases hindlimb oxygen uptake and lactate efflux without increases in perfusion pressure, also decreased MTT formazan production.	Oxygen	60-66	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	15-28
10021497-5	1998	P50 (partial oxygen pressure at 50% hemoglobin oxygen saturation) in whole blood increased as the concentration of RSR-4 increased.	Oxygen	13-19	Y-box-binding protein 1	Oryctolagus cuniculus	0-3
10021497-5	1998	P50 (partial oxygen pressure at 50% hemoglobin oxygen saturation) in whole blood increased as the concentration of RSR-4 increased.	Oxygen	47-53	Y-box-binding protein 1	Oryctolagus cuniculus	0-3
9817793-12	1998	From these results it is concluded that: (1) low flow samples under control physiological conditions are unlikely to be in a state of hibernation or stunning since their HSP70 concentration is normal and (2) the increase in the local HSP70 concentration during myocardial ischaemia reflects the degree of impairment of O2 delivery.	Oxygen	319-321	heat shock 70 kDa protein 1	Canis lupus familiaris	234-239
9833810-1	1998	OBJECTIVE: To examine the temporal integration of vascular endothelial growth factor (VEGF), which has been shown to be present in wound fluid, with the putatively related processes of wound fluid oxygen content, wound angiogenesis, and granulation tissue formation.	Oxygen	197-203	vascular endothelial growth factor A	Sus scrofa	50-84
9833810-1	1998	OBJECTIVE: To examine the temporal integration of vascular endothelial growth factor (VEGF), which has been shown to be present in wound fluid, with the putatively related processes of wound fluid oxygen content, wound angiogenesis, and granulation tissue formation.	Oxygen	197-203	vascular endothelial growth factor A	Sus scrofa	86-90
11081979-1	2000	Hap1 and Rox1 are transcriptional regulators that bind regulatory sites in the promoters of oxygen-regulated genes in Saccharomyces cerevisiae.	Oxygen	92-98	Hap1p	Saccharomyces cerevisiae S288C	0-4
26927670-6	2016	Moreover, suppression of renal EPO production was associated with increased glucose uptake, enhanced glycolysis, reduced mitochondrial mass, diminished O2 consumption, and elevated renal tissue pO2.	Oxygen	152-154	erythropoietin	Mus musculus	31-34
9791005-7	1998	Our data suggest a different sensitivity for the cytotoxic action of IAPP fibrils between RINm5F and HIT-T15 cells, which may be ascribed to different sensitivity to formation and action of oxygen intermediates.	Oxygen	190-196	islet amyloid polypeptide	Rattus norvegicus	69-73
11007896-8	2000	Erythropoietin supplementation of 20% O(2) cultures partially mimicked increased dopaminergic differentiation characteristic of CNS precursors cultured in lowered O(2).	Oxygen	38-42	erythropoietin	Rattus norvegicus	0-14
26755203-7	2016	In vivo, CD26-I-treated and CD26KO mice showed significantly preserved macroscopic and histologic characteristics on Day 5 (p &lt; 0.01), a higher partial pressure of arterial oxygen/fraction of inspired oxygen ratio (p &lt;= 0.05), fewer infiltrating CD3(+) T cells (p &lt; 0.01), but more interstitial macrophages on Day 1 (p &lt; 0.01) compared with control.	Oxygen	176-182	dipeptidylpeptidase 4	Mus musculus	9-13
11007896-8	2000	Erythropoietin supplementation of 20% O(2) cultures partially mimicked increased dopaminergic differentiation characteristic of CNS precursors cultured in lowered O(2).	Oxygen	163-167	erythropoietin	Rattus norvegicus	0-14
11014986-1	2000	BACKGROUND: There is evidence from in vitro studies to suggest that the genes of platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) are, like the erythropoietin gene, regulated by oxygen tension.	Oxygen	214-220	vascular endothelial growth factor A	Rattus norvegicus	124-158
11014986-1	2000	BACKGROUND: There is evidence from in vitro studies to suggest that the genes of platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) are, like the erythropoietin gene, regulated by oxygen tension.	Oxygen	214-220	vascular endothelial growth factor A	Rattus norvegicus	160-164
11014986-1	2000	BACKGROUND: There is evidence from in vitro studies to suggest that the genes of platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) are, like the erythropoietin gene, regulated by oxygen tension.	Oxygen	214-220	erythropoietin	Rattus norvegicus	180-194
9778344-5	1998	The epsilon and eta nitrogens of the guanidinium side chain of Arg-39" from a neighboring dimer interact respectively with the C-2 carbonyl oxygen and one C-1 carboxylate oxygen of the adduct while the side chain of Arg-61" from the same dimer as the modified Pro-1 interacts with the C-1 carboxylate group in a bidentate fashion.	Oxygen	140-146	lamin A/C	Homo sapiens	260-265
9778344-5	1998	The epsilon and eta nitrogens of the guanidinium side chain of Arg-39" from a neighboring dimer interact respectively with the C-2 carbonyl oxygen and one C-1 carboxylate oxygen of the adduct while the side chain of Arg-61" from the same dimer as the modified Pro-1 interacts with the C-1 carboxylate group in a bidentate fashion.	Oxygen	171-177	lamin A/C	Homo sapiens	260-265
26755203-7	2016	In vivo, CD26-I-treated and CD26KO mice showed significantly preserved macroscopic and histologic characteristics on Day 5 (p &lt; 0.01), a higher partial pressure of arterial oxygen/fraction of inspired oxygen ratio (p &lt;= 0.05), fewer infiltrating CD3(+) T cells (p &lt; 0.01), but more interstitial macrophages on Day 1 (p &lt; 0.01) compared with control.	Oxygen	204-210	dipeptidylpeptidase 4	Mus musculus	9-13
9833145-5	1998	We propose that, on day 1, a brief ischemic stress causes increased production of NO (probably via eNOS) and .O2-, which then react to form ONOO-, ONOO-, in turn, activates the epsilon isoform of protein kinase C (PKC), either directly or via its reactive byproducts such as .OH.	Oxygen	110-112	protein kinase C epsilon	Homo sapiens	214-217
26949511-12	2016	PHD2 conditional knockout mice may serve as a model for chronic HIF-1alpha stabilization as in mice exposed to low oxygen concentration.	Oxygen	115-121	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
9753662-1	1998	gamma-Butyrobetaine hydroxylase (EC 1.14.11.1) is the last enzyme in the biosynthetic pathway of L-carnitine and catalyzes the formation of L-carnitine from gamma-butyrobetaine, a reaction dependent on alpha-ketoglutarate, Fe2+, and oxygen.	Oxygen	233-239	gamma-butyrobetaine hydroxylase 1	Homo sapiens	0-31
11045713-7	2000	In the presence of oxygen, O2*- is formed but the photoreduction of Cyt Fe3+ by O2*- competes with an oxidizing pathway which involves photo-oxidation products of TrpH.	Oxygen	19-25	tryptophan hydroxylase 1	Homo sapiens	163-167
11045713-7	2000	In the presence of oxygen, O2*- is formed but the photoreduction of Cyt Fe3+ by O2*- competes with an oxidizing pathway which involves photo-oxidation products of TrpH.	Oxygen	27-29	tryptophan hydroxylase 1	Homo sapiens	163-167
11045713-7	2000	In the presence of oxygen, O2*- is formed but the photoreduction of Cyt Fe3+ by O2*- competes with an oxidizing pathway which involves photo-oxidation products of TrpH.	Oxygen	80-82	tryptophan hydroxylase 1	Homo sapiens	163-167
10978514-1	2000	The heterodimeric hypoxia-inducible factor-1 (HIF-1), consisting of the subunits HIF-1alpha and HIF-1beta/ARNT, is a master transcriptional regulator of oxygen homeostasis.	Oxygen	153-159	aryl hydrocarbon receptor nuclear translocator	Mus musculus	106-110
10996353-3	2000	p22 phox, a component of the NADH/NADPH oxidase in phagocytes and vascular smooth muscle cells, is essential for production of reactive oxygen metabolites.	Oxygen	136-142	calcineurin like EF-hand protein 1	Homo sapiens	0-3
9727060-9	1998	Furthermore, homozygous null uPA (uPA -/-) and tPA (tPA -/-) mice subjected to oxygen deprivation showed increased fibrin deposition compared with wild-type controls.	Oxygen	79-85	plasminogen activator, urokinase	Mus musculus	29-32
9727060-10	1998	These studies identify enhanced expression of PAI-1 as an important mechanism suppressing fibrinolysis under conditions of low oxygen tension, a response which may be further amplified by decreased expression of plasminogen activators.	Oxygen	127-133	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	46-51
9712182-0	1998	Effect of N-methyl-D-aspartate receptor blockade on the control of cerebral O2 supply/consumption balance during hypoxia in newborn pigs.	Oxygen	76-78	glutamate ionotropic receptor NMDA type subunit 1	Sus scrofa	10-39
26698668-4	2016	Affymetrix array profiling and subsequent qPCR/protein validation revealed that induction of select Nrf2 target genes, HO-1 and NQO1, was significantly attenuated in cells adapted to 5% O2, despite nuclear accumulation and DNA binding of Nrf2.	Oxygen	186-188	heme oxygenase 1	Homo sapiens	119-123
9778121-4	1998	Northern blot analysis showed that clones HRF-1 and HRF-2 were downregulated in response to exposure to low levels of oxygen, whereas expression of HRF-6 and HRF-8 was increased.	Oxygen	118-124	zinc finger protein 195	Homo sapiens	42-47
10995354-5	2000	Further model experiments gave evidence that a transition-metal-catalyzed oxidation of the ARP-Phe by air oxygen into the 2-hexosulose-(phenylalanine) imine is the key step responsible for the favored formation of phenylacetaldehyde from the Amadori compound.	Oxygen	106-112	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	91-94
10972830-4	2000	We found that Hap1p activity, known to be oxygen dependent, is effected by DNA-protein interaction with two binding sites present in the CYB2 promoter.	Oxygen	42-48	Hap1p	Saccharomyces cerevisiae S288C	14-19
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	35-37	heme oxygenase 1	Homo sapiens	11-15
26698668-5	2016	Diminished HO-1 induction under 5% O2 was stimulus independent and reversible upon re-adaptation to air or silencing of the Nrf2 repressor Bach1, notably elevated under 5% O2.	Oxygen	172-174	heme oxygenase 1	Homo sapiens	11-15
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	49-55	solute carrier family 7 member 11	Homo sapiens	31-34
10998176-2	2000	The sensor-regulator pair, ArcB-ArcA, is responsible for the microaerobic activation of the cydAB operon, whereas the anaerobic regulator Fnr represses its expression in the absence of oxygen.	Oxygen	185-191	hypothetical protein	Escherichia coli	27-31
9772750-4	1998	In particular, the very low specific consumption rate (0.2 x 10(-12) mol cell h-1), the sensitivity of the cells to variations in dissolved oxygen concentration and the difficulty to provide oxygen without damaging the cells are problems which must be taken into account for the development of OUR measurement methods.	Oxygen	140-146	H1.5 linker histone, cluster member	Homo sapiens	78-81
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	112-114	solute carrier family 7 member 11	Homo sapiens	31-34
26698668-6	2016	Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo.	Oxygen	273-275	solute carrier family 7 member 11	Homo sapiens	31-34
10919818-9	2000	When deprived of oxygen for 2.5 days, MF1 did not regain the ability to grow on VC, and a portion of the VC was transformed into VC-epoxide.	Oxygen	17-23	flap structure-specific endonuclease 1	Homo sapiens	38-41
26982166-3	2016	We found that elevations of whole lung HMGB1 level were associated with impaired alveolar development and aberrant elastin production in 85% O2-exposed lungs.	Oxygen	141-143	elastin	Mus musculus	115-122
10924897-1	2000	In studies on metabolism of vascular smooth muscle, it was observed that incubation of intact porcine carotid artery strips with 3% bovine or porcine serum albumin had profound effects on the oxidation of substrates and O2 consumption.	Oxygen	220-222	albumin	Bos taurus	150-163
9701281-4	1998	Specifically, sulfur substitution of the pro-Sp nonbridging oxygen at the 5" splice site reduces the chemical rate of the step one branching reaction by at least 250-fold, whereas substitution of the pro-Sp oxygen at the 3" splice site has only a 4.5-fold effect on the chemical rate of step two.	Oxygen	60-66	protein S (beta) pseudogene	Homo sapiens	41-47
9701281-4	1998	Specifically, sulfur substitution of the pro-Sp nonbridging oxygen at the 5" splice site reduces the chemical rate of the step one branching reaction by at least 250-fold, whereas substitution of the pro-Sp oxygen at the 3" splice site has only a 4.5-fold effect on the chemical rate of step two.	Oxygen	207-213	protein S (beta) pseudogene	Homo sapiens	200-206
26919427-3	2016	We created mouse models to ask if inhibition of the alpha-ketoglutarate (alphaKG)-dependent dioxygenase Egln1, which senses oxygen and regulates the hypoxia-inducible factor (HIF) transcription factor, could suffice to mediate local and remote ischemic preconditioning.	Oxygen	94-100	egl-9 family hypoxia-inducible factor 1	Mus musculus	104-109
9653181-9	1998	These data delineate a novel biology for hypoxia-induced fibrin deposition, in which oxygen deprivation-induced activation of Egr-1, resulting in expression of tissue factor, has an unexpected and central role.	Oxygen	85-91	early growth response 1	Mus musculus	126-131
11002391-9	2000	The results indicate that plasma-treated SPs bind Ig and are internalized by differentiated monocytic cells via FcgammaRI, which is known to trigger cellular production of toxic oxygen species that may induce pulmonary inflammation in vivo.	Oxygen	178-184	Fc gamma receptor Ia	Homo sapiens	112-121
26892324-8	2016	Among these genes, the most evident one was endothelial PAS domain protein 1 (EPAS1), which has been previously reported to be involved in complex oxygen sensing and significantly associated with high-altitude adaptation of human, dog, and grey wolf.	Oxygen	147-153	endothelial PAS domain protein 1	Homo sapiens	44-76
10929046-7	2000	By comparison, hybrid haemoglobins containing either human epsilon-globin or human beta-globin exhibited nearly identical O2-binding properties, both in situ and in vitro, regardless of 2,3-BPG levels or ambient pH.	Oxygen	122-124	hemoglobin subunit beta	Homo sapiens	83-94
9733146-3	1998	Previous studies from our laboratory have demonstrated that tyrosine phosphorylation of p105 and p81 (p105/81), the two major human sperm phosphotyrosine-containing proteins, was under cAMP and oxygen derivatives regulation.	Oxygen	194-200	ezrin	Homo sapiens	97-100
9632766-2	1998	To gain insights into molecular mechanisms of heme signaling and oxygen sensing in eukaryotes, we investigated the yeast heme-responsive transcriptional activator HAP1.	Oxygen	65-71	Hap1p	Saccharomyces cerevisiae S288C	163-167
9609747-6	1998	Similarly, AQP-4 expression increases in FDLE cells exposed to 21% O2 compared with cells exposed to 3% O2.	Oxygen	67-69	aquaporin 4	Rattus norvegicus	11-16
9609747-8	1998	Exposure to ambient 21% O2 may contribute to increases in AQP-4 and ENaC expression to facilitate water transport across neonatal airway epithelia in the immediate postnatal period.	Oxygen	24-26	aquaporin 4	Rattus norvegicus	58-63
10936758-2	2000	Furthermore, myoglobin content is a key oxygen store in the muscle as it is many times higher in marine mammals than terrestrial mammals.	Oxygen	40-46	myoglobin	Homo sapiens	13-22
10846049-0	2000	Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration.	Oxygen	84-90	early growth response 1	Mus musculus	24-47
10846049-3	2000	Within 30 min of hypoxia, Egr-1 transcripts were approximately 20-fold elevated in 6% oxygen, approximately 5.2-fold increased by 10% oxygen, and returned to the normoxic baseline by 12% oxygen.	Oxygen	86-92	early growth response 1	Mus musculus	26-31
10846049-3	2000	Within 30 min of hypoxia, Egr-1 transcripts were approximately 20-fold elevated in 6% oxygen, approximately 5.2-fold increased by 10% oxygen, and returned to the normoxic baseline by 12% oxygen.	Oxygen	134-140	early growth response 1	Mus musculus	26-31
26892324-8	2016	Among these genes, the most evident one was endothelial PAS domain protein 1 (EPAS1), which has been previously reported to be involved in complex oxygen sensing and significantly associated with high-altitude adaptation of human, dog, and grey wolf.	Oxygen	147-153	endothelial PAS domain protein 1	Homo sapiens	78-83
10846049-3	2000	Within 30 min of hypoxia, Egr-1 transcripts were approximately 20-fold elevated in 6% oxygen, approximately 5.2-fold increased by 10% oxygen, and returned to the normoxic baseline by 12% oxygen.	Oxygen	134-140	early growth response 1	Mus musculus	26-31
9618302-0	1998	Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice.	Oxygen	57-63	leptin	Mus musculus	0-6
26599691-6	2016	The result indicated that the expression of glutathione-dependent enzymes (GSTA, M, P, and GPX2) was sensitive to oxygen and medium type.	Oxygen	114-120	glutathione peroxidase 2	Homo sapiens	91-95
9578604-9	1998	These results suggest that G-CSF would enhance the organization of a receptor-linked DAG generating system in the differentiating cells, leading the cells to generate more O2.	Oxygen	172-174	colony stimulating factor 3	Homo sapiens	27-32
10841376-5	2000	The increased L-ENK was returned to normoxic level when hypoxia (10.8% O2) exposure lasted for 24 h. After ADX, 10.8% O2 hypoxia induced a sharp decline of L-ENK in the ME, but this decline was completely reversed by treatment with DEX (500 microg/rat, i.p.).	Oxygen	71-73	proenkephalin	Rattus norvegicus	16-19
10841376-5	2000	The increased L-ENK was returned to normoxic level when hypoxia (10.8% O2) exposure lasted for 24 h. After ADX, 10.8% O2 hypoxia induced a sharp decline of L-ENK in the ME, but this decline was completely reversed by treatment with DEX (500 microg/rat, i.p.).	Oxygen	118-120	proenkephalin	Rattus norvegicus	16-19
10841376-5	2000	The increased L-ENK was returned to normoxic level when hypoxia (10.8% O2) exposure lasted for 24 h. After ADX, 10.8% O2 hypoxia induced a sharp decline of L-ENK in the ME, but this decline was completely reversed by treatment with DEX (500 microg/rat, i.p.).	Oxygen	118-120	proenkephalin	Rattus norvegicus	158-161
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	phosphoglycerate kinase 1	Homo sapiens	81-106
9576798-6	1998	Maximal extractable Suc phosphate synthase activities decreased as a result of water stress, and there was an increase in the sensitivity to the inhibitor orthophosphate. A correlation between maximal extractable foliar nitrate reductase (NR) activity and the rate of CO2 assimilation was observed.	Oxygen	269-272	nitrate reductase [NADH] 1	Zea mays	221-238
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	phosphoglycerate kinase 1	Homo sapiens	108-112
10865838-7	2000	At low O2 tension, hypoxia inducible factor-1 alpha (HIF-1 alpha), a limiting factor rapidly stabilized and phosphorylated, plays a key role in the expression of several genes including VEGF.	Oxygen	7-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	19-51
10865838-7	2000	At low O2 tension, hypoxia inducible factor-1 alpha (HIF-1 alpha), a limiting factor rapidly stabilized and phosphorylated, plays a key role in the expression of several genes including VEGF.	Oxygen	7-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	53-64
26955501-9	2016	RESULTS: Based on pimonidazole staining and other hypoxia.related proteins (osteopontin, hypoxia-inducible factor 1-alpha, and glucose transporter member 1) oxygen supply maps in prostate cancer were created.	Oxygen	157-163	secreted phosphoprotein 1	Homo sapiens	76-87
10879688-0	2000	Human MO subsets as defined by expression of CD64 and CD16 differ in phagocytic activity and generation of oxygen intermediates.	Oxygen	107-113	Fc gamma receptor Ia	Homo sapiens	45-49
9548931-2	1998	The electron-withdrawing carboxylate groups directly attached to the porphyrin ring lowered the oxygen affinity by 3-fold as compared with native myoglobin.	Oxygen	96-102	myoglobin	Homo sapiens	146-155
26981502-2	2016	Hyperbaric oxygen therapy (HBO) is defined as a treatment in which a patient is intermittently exposed to 100% oxygen pressurized to a pressure above sea level (&gt; 2.0 atmospheres absolute (ATA), 1.0 ATA = 760 mmHg).	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	150-153
9575883-1	1998	Expression of insulin-like growth factor (IGF) I and its type I receptor is increased in the adult rat lung exposed to 85% O2.	Oxygen	123-125	insulin-like growth factor 1	Rattus norvegicus	14-48
9575883-4	1998	O2 exposure for 6 or 14 days reduced IGFBP-3 and -6 and increased IGFBP-4 mRNA abundance.	Oxygen	0-2	insulin-like growth factor binding protein 3	Rattus norvegicus	37-51
9575883-11	1998	These data are consistent with the predicted changes for IGFBPs on O2 exposure except that the generally growth-inhibitory IGFBP-4 was increased at sites of active cell proliferation.	Oxygen	67-69	insulin-like growth factor binding protein 1	Rattus norvegicus	57-63
10779019-1	2000	The coupling between cerebral metabolic rate of oxygen (CMRO2) and blood flow (CBF) in response to visual stimulation was evaluated by means of a model of oxygen delivery.	Oxygen	155-161	CCAAT enhancer binding protein zeta	Homo sapiens	79-82
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	Oxygen	62-68	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	113-119
10793443-10	2000	Ascent to 4,000 m above sea level induced a significant decrease in arterial pO2 (10.7 +/- 1.1 vs 5.5 +/- 0.3 kPa), pCO2 (5.3 +/- 0.3 vs 4.7 +/- 0.4 kPa), oxygen saturation measured by arterial blood gas analysis (95.5% +/- 1.2% vs 79.1% +/- 2.5%), and increase in pH (7.39 +/- 0.02 vs 7.45 +/- 0.04) (P &lt; 0.0001).	Oxygen	155-161	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
10694440-3	2000	We examined expression of uPAR mRNA in MCF7 human breast carcinoma cells under hypoxia and found that an increase in the level of the message could be detected at 1% oxygen but was most marked at 0.2 or 0.05% oxygen with an induction of 9- to 20-fold over baseline.	Oxygen	166-172	plasminogen activator, urokinase receptor	Homo sapiens	26-30
10694440-3	2000	We examined expression of uPAR mRNA in MCF7 human breast carcinoma cells under hypoxia and found that an increase in the level of the message could be detected at 1% oxygen but was most marked at 0.2 or 0.05% oxygen with an induction of 9- to 20-fold over baseline.	Oxygen	209-215	plasminogen activator, urokinase receptor	Homo sapiens	26-30
11272563-10	2000	The terminal Mn(II) atoms are seven-coordinate with a distorted mono-face-capped octahedral geometry ligated by the (aldose)3-tren ligand through three oxygen atoms of C-2 hydroxyl groups, three N-glycosidic nitrogen atoms, and a tertiary amino group.	Oxygen	152-158	complement C2	Homo sapiens	168-171
10653645-1	2000	In thymidylate synthase, four conserved arginines provide two hydrogen bonds each to the oxygens of the phosphate group of the substrate, 2"-deoxyuridine-5"-monophosphate.	Oxygen	89-96	thymidylate synthetase	Homo sapiens	3-23
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	166-168	sucrose synthase 1	Zea mays	13-16
9669840-7	1998	However, ex vivo expansion of the sorted subsets with interleukin 3, stem cell factor and FLT3 ligand for 2 weeks resulted in a significant production of O2- and H2O2/HOCl by CD34+/CD117low cell fraction, compared to the same sorted but not expanded counterparts.	Oxygen	154-156	interleukin 3	Homo sapiens	54-67
9454748-0	1998	Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner.	Oxygen	108-114	interleukin 23 subunit alpha	Homo sapiens	20-23
9597146-2	1998	His early work on the quest for the cell that produces erythropoietin (Epo) to his current work on oxygen sensing and signal transduction pathways involved in erythropoietin gene expression are reported.	Oxygen	99-105	erythropoietin	Mus musculus	55-69
9597146-2	1998	His early work on the quest for the cell that produces erythropoietin (Epo) to his current work on oxygen sensing and signal transduction pathways involved in erythropoietin gene expression are reported.	Oxygen	99-105	erythropoietin	Mus musculus	159-173
9426593-2	1997	The use of gene-specific probes on northern blots showed that Ldh2 mRNA was predominant in well-oxygenated roots and levels remained stable upon oxygen deficit; in contrast, Ldh1 mRNA accumulated to high levels within 2 h of hypoxia or anoxia.	Oxygen	96-102	L-lactate dehydrogenase	Solanum lycopersicum	62-66
9374817-8	1997	We conclude that during chronic O2 deprivation, GLUT-1 and GLUT-4 expressions show a similar pattern but greatly depend on tissue type and age.	Oxygen	32-34	solute carrier family 2 member 4	Rattus norvegicus	59-65
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 1	Zea mays	13-16
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 1	Zea mays	13-16
10938850-7	2000	The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals.	Oxygen	180-182	sucrose synthase 1	Zea mays	13-16
27343101-3	2016	Genetic adaptation to hypoxia is under control of hypoxia-inducible factors (HIFs), of which two highly homologous subunits HIF-1alpha and HIF-2alpha are regulated by oxygen tension.	Oxygen	167-173	endothelial PAS domain protein 1	Homo sapiens	139-149
10639526-11	2000	RESULTS: A significant (p&lt;0.05) fall was observed in PVR (183.1 (116.05) and 137.2 (108.4) dynes.s.cm(-3) before and after breathing NO for 24 hours, respectively) with NO administration without significant changes in symptoms, pulmonary function, arterial oxygen tension, or exercise tolerance.	Oxygen	260-266	PVR cell adhesion molecule	Homo sapiens	56-59
10639526-12	2000	CONCLUSIONS: NO at a concentration of 25 ppm blended with oxygen can be safely administered by nasal cannula for 24 hours without significant adverse effects and lowers PVR in stable patients with COPD receiving long term oxygen therapy.	Oxygen	58-64	PVR cell adhesion molecule	Homo sapiens	169-172
9370470-1	1997	The detection of the 1H NMR signal of myoglobin (Mb) in tissue opens an opportunity to examine its cellular diffusion property, which is central to its purported role in facilitating oxygen transport.	Oxygen	183-189	myoglobin	Homo sapiens	38-47
9370470-1	1997	The detection of the 1H NMR signal of myoglobin (Mb) in tissue opens an opportunity to examine its cellular diffusion property, which is central to its purported role in facilitating oxygen transport.	Oxygen	183-189	myoglobin	Homo sapiens	49-51
9370470-3	1997	Such a mobility is consistent with the theory that Mb facilitates oxygen diffusion from the sarcoplasm to the mitochondria.	Oxygen	66-72	myoglobin	Homo sapiens	51-53
27889750-0	2016	Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B.	Oxygen	35-41	mitotic arrest deficient 2 like 2	Homo sapiens	111-116
9379708-4	1997	The objective of this study was to examine the effect on the bone forming activity of osteoblasts using an oxygen free radical treated FN substratum in vitro (H2O2-Cu2+system).	Oxygen	107-113	fibronectin 1	Rattus norvegicus	135-137
10667562-0	2000	Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.	Oxygen	145-151	hematopoietic prostaglandin D synthase	Rattus norvegicus	20-45
26891660-7	2016	PDGF-BB and oxygen-deprivation dramatically reduced PDGFRbeta expression, while TGFbeta1 increased its expression.	Oxygen	12-18	platelet derived growth factor receptor, beta polypeptide	Mus musculus	52-61
10849651-4	2000	Whereas hypoxia prevents ubiquitination and proteasomal degradation of HIF-1 alpha, ARNT expression is thought to be oxygen-independent.	Oxygen	117-123	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	84-88
12881888-4	2000	Within the myocyte a portion of the O2 diffuses directly to the mitochondria, while the remaining O2 is transported by facilitated diffusion bound to myoglobin, a heme protein found in muscle.	Oxygen	98-100	myoglobin	Homo sapiens	150-159
12881888-7	2000	Myoglobin, a fundamental constituent of cardiac muscle is essential for delivering O2 to the mitochondria.	Oxygen	83-85	myoglobin	Homo sapiens	0-9
12881888-10	2000	Consequently, the role of myoglobin as a cellular transporter of O2 is seriously impaired by heart disease.	Oxygen	65-67	myoglobin	Homo sapiens	26-35
12881888-11	2000	Carbon monoxide reduces O2 transport to the tissues and, within the tissues, binds with myoglobin to form carboxymyoglobin (COMb).	Oxygen	24-26	myoglobin	Homo sapiens	88-97
10836051-2	1999	The oxygen-carbon bond at C-1 was incorporated with complete stereoselectivity by using an efficient phenylselenocyclocarbamation reaction.	Oxygen	4-10	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	26-29
10322893-7	1997	CONCLUSIONS: BYHWD increased SOD-1 gene expression of artery endothelium, to improve oxygen feed for ischemia reperfusion in the same way, BYHWD suppressed PDGFR mRNA expression to control cellular pathological proliferation.	Oxygen	85-91	superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	29-34
9278421-4	1997	The HIF-1alpha subunit is continuously synthesized and degraded under normoxic conditions, while it accumulates rapidly following exposure to low oxygen tensions.	Oxygen	146-152	hypoxia inducible factor 1, alpha subunit	Mus musculus	4-14
9316487-4	1997	Pulmonary gamma-GT activity increased in the 60 and 85% O2-exposed animals (1.6- and 3.2-fold, respectively), and tissue GSH levels increased only in the 60% O2 group (1.3-fold).	Oxygen	56-58	gamma-glutamyltransferase 1	Rattus norvegicus	10-18
26903689-6	2016	Further, PAI-1 levels correlated to blood oxygen (r = -0.68, p &lt; 0.0001).	Oxygen	42-48	serpin family E member 1	Homo sapiens	9-14
9315320-3	1997	Incubation of selenite or GS-Se-SG with the Trx system or with mammalian TR results in a rapid formation of selenide, which by redox cycling with oxygen may cause a large non-stoichiometric oxidation of NADPH.	Oxygen	146-152	thioredoxin	Homo sapiens	44-47
10570058-6	1999	Both L-arginine (10 mM) and NOC-18 (0.3 mM) counteracted the stimulatory effect on hERG1 outward currents induced by the radical oxygen species-generating system FeSO(4) (25 microM)/ascorbic acid (50 microM; Fe/Asc).	Oxygen	129-135	potassium voltage-gated channel subfamily H member 2	Homo sapiens	83-88
10570058-8	1999	Collectively, the present results suggest that NO(*), both endogenously produced and pharmacologically delivered, may exert in a cGMP-independent way an inhibitory effect on hERG1 outward K(+) currents via an interaction with radical oxygen species either generated under resting conditions or triggered by Fe/Asc.	Oxygen	234-240	potassium voltage-gated channel subfamily H member 2	Homo sapiens	174-179
27012070-3	2016	Mutations causing decreased affinity of hemoglobin to oxygen may change alpha1 to beta2 binding.	Oxygen	54-60	adrenoceptor alpha 1D	Homo sapiens	72-78
10625471-3	1999	One of the active site residues is lysine-32, which is postulated to play two roles: it assists in substrate binding through an interaction with a carboxylate oxygen at C-1 of phenylpyruvate, and it may be partially responsible for lowering the pK(a) of the catalytic base, Pro-1.	Oxygen	159-165	lamin A/C	Homo sapiens	274-279
9504069-3	1997	Above sea level, oxygen concentration diminishes.	Oxygen	17-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	6-9
26501487-6	2016	Oxygen tension within the pregnant uterus, which contributes to the vascular development, also affects EFNB2 and EPHB4 expression.	Oxygen	0-6	ephrin B2	Mus musculus	103-108
9360416-0	1997	Studies on the oxygen transport in the clinical association between Hb-S and Hb-C.	Oxygen	15-21	keratin 88, pseudogene	Homo sapiens	77-81
10597900-11	1999	The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required.	Oxygen	130-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
10564111-8	1999	Furthermore, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide, a cell-permeable inhibitor of protein kinase A (PKA), reduced the stimulation of oxygen uptake by PGE(2).	Oxygen	155-161	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	104-120
27493706-5	2016	A single dose of erythropoietin (20,000 IU/kg) at the onset of hyperoxia (24 hours, 80% oxygen) in 6-day-old Wistar rats improved long-lasting neurocognitive development up to the adolescent and adult stage.	Oxygen	88-94	erythropoietin	Rattus norvegicus	17-31
10564111-8	1999	Furthermore, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide, a cell-permeable inhibitor of protein kinase A (PKA), reduced the stimulation of oxygen uptake by PGE(2).	Oxygen	155-161	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	122-125
9307122-0	1997	Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro.	Oxygen	74-80	carbonic anhydrase 1	Rattus norvegicus	112-115
26452589-0	2016	Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis.	Oxygen	83-89	erythropoietin	Mus musculus	15-29
9263988-0	1997	Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats.	Oxygen	46-52	erythropoietin	Rattus norvegicus	77-91
9263988-1	1997	This in vivo study investigated whether adenosine (ADO) plays a role in oxygen-dependent production of erythropoietin (EPO).	Oxygen	72-78	erythropoietin	Rattus norvegicus	103-117
9263988-1	1997	This in vivo study investigated whether adenosine (ADO) plays a role in oxygen-dependent production of erythropoietin (EPO).	Oxygen	72-78	erythropoietin	Rattus norvegicus	119-122
26639784-8	2015	PKM2 expression was increased in hESCs cultured at 5% oxygen compared to 20% oxygen and silencing PKM2 reduced OCT4 expression highlighting a transcriptional role for PKM2 in hESCs.	Oxygen	54-60	pyruvate kinase M1/2	Homo sapiens	0-4
26639784-8	2015	PKM2 expression was increased in hESCs cultured at 5% oxygen compared to 20% oxygen and silencing PKM2 reduced OCT4 expression highlighting a transcriptional role for PKM2 in hESCs.	Oxygen	77-83	pyruvate kinase M1/2	Homo sapiens	0-4
26343184-4	2015	253J-BV cells display higher basal MMP-1 expression, which is further enhanced under hypoxic conditions (1% O2).	Oxygen	108-110	matrix metallopeptidase 1	Homo sapiens	35-40
26475491-2	2015	Thus, the aim of this study was to investigate the influence of the whole body cryostimulation (CRY) on irisin, a myokine which activates oxygen consumption in fat cells as well as thermogenesis.	Oxygen	138-144	fibronectin type III domain containing 5	Homo sapiens	104-110
26545615-12	2015	Such reduction was not observed when tumor CD73 was knocked down due to the much slower tumor growth and decreased oxygen demand as indicated by the low expression of Bad, a hypoxia marker.	Oxygen	115-121	5' nucleotidase, ecto	Mus musculus	43-47
26018820-10	2015	The up-regulation of connexin43 in combination with the down-regulation of connexin46 was confirmed in placental explants cultivated under low oxygen and in placentas with early-onset PE.	Oxygen	143-149	gap junction protein alpha 3	Homo sapiens	75-85
26375300-6	2015	In addition, cultured cortical neurons treated with the rpS6 kinase (S6K) inhibitors, D-glucosamine or PF4708671, displayed a decrease in rpS6 phosphorylation and a subsequent increase in tolerance to oxygen/glucose deprivation, an in vitro model of ischemic stroke.	Oxygen	201-207	ribosomal protein S6 kinase B1	Rattus norvegicus	69-72
26506135-0	2015	GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.	Oxygen	89-95	G protein-coupled receptor kinase 2	Mus musculus	0-4
26506135-6	2015	Inhibition of GRK2 increased oxygen consumption rates and ATP production.	Oxygen	29-35	G protein-coupled receptor kinase 2	Mus musculus	14-18
26399516-9	2015	Consistent with previous findings, irisin significantly increased expression of several genes including peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) leading to increased mitochondrial content and oxygen consumption.	Oxygen	232-238	fibronectin type III domain containing 5	Homo sapiens	35-41
26319679-0	2015	Therapeutic effect of tPA in ischemic stroke is enhanced by its combination with normobaric oxygen and hypothermia or ethanol.	Oxygen	92-98	plasminogen activator, tissue type	Rattus norvegicus	22-25
26452156-8	2015	The industrial measurements showed that NOx emissions at full load decreased significantly by 50%, from 1501 mg/m3 (O2 at 6%) to 751 mg/m3 (O2 at 6%).	Oxygen	116-118	NADPH oxidase	Drosophila melanogaster	40-43
26452156-8	2015	The industrial measurements showed that NOx emissions at full load decreased significantly by 50%, from 1501 mg/m3 (O2 at 6%) to 751 mg/m3 (O2 at 6%).	Oxygen	140-142	NADPH oxidase	Drosophila melanogaster	40-43
26738203-0	2015	Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity".	Oxygen	96-102	myosin heavy chain 14	Homo sapiens	39-45
26738203-0	2015	Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity".	Oxygen	96-102	myosin heavy chain 14	Homo sapiens	166-172
26125516-5	2015	When the water coating is removed, the X-ray photoelectron spectroscopy pattern of V2p showed that the V-MOF changes to MIL-100V(IV) and MIL-101V(IV) at 298 K because of the action of O2.	Oxygen	184-186	T cell receptor gamma variable 9	Homo sapiens	83-86
26327529-0	2015	Interactions of hemoglobin and myoglobin with their ligands CN(-), CO, and O2 monitored by electrospray ionization-mass spectrometry.	Oxygen	75-77	myoglobin	Homo sapiens	31-40
26327529-5	2015	In analogous fashion, CN(-), CO, and O2 bind to myoglobin (Mb).	Oxygen	37-39	myoglobin	Homo sapiens	48-57
25980632-8	2015	A negative correlation was observed between this increase in ANGPTL2 levels and the mean rate-pressure product (heart rate x systolic blood pressure; index of myocardial O2 consumption) measured during MICE, suggesting that subclinical ischemia might promote ANGPTL2 expression.	Oxygen	170-172	angiopoietin-like 2	Mus musculus	61-68
26265081-1	2015	We report the generation and spectroscopic characterization of a heterobimetallic [(TMC)Fe(III)-O-Cr(III)(OTf)4] species (1) by bubbling O2 into a mixture of Fe(TMC)(OTf)2 and Cr(OTf)2 in NCCH3.	Oxygen	137-139	POU class 5 homeobox 1	Homo sapiens	106-111
26373931-1	2015	BACKGROUND: Sea level sojourners, on ascent to high altitude, undergo acclimatization through integrated physiological processes for defending the body against oxygen deprivation while the high altitude natives (resident population) are adapted to the prevailing hypobaric hypoxic condition through natural selection.	Oxygen	160-166	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
25924886-5	2015	These values are similar to predicted chemical interactions of PEG -CH2 OCH2 - groups with these protein components (BSA ~3.3 kcal/mol, lysozyme ~0.7 kcal/mol), dominated by unfavorable interactions with amide and carboxylate oxygens and counterions.	Oxygen	226-233	progestagen associated endometrial protein	Homo sapiens	63-66
25850685-0	2015	Effect of oxygen and glucose deprivation on VEGF and its receptors in microvascular endothelial cells co-cultured with mast cells.	Oxygen	10-16	vascular endothelial growth factor A	Rattus norvegicus	44-48
9483174-4	1997	In addition, inhibition of NADPH oxidase and/or NO synthase which are major sources of active oxygen species in phagocytes also blocked TF induction.	Oxygen	94-100	coagulation factor III, tissue factor	Homo sapiens	136-138
9483174-5	1997	The restoration of TF expression, in monocytes treated with inhibitors of reactive oxygen production, by N,N"-dimethyl-gamma, gamma"-dipyridylium dichloride and/or sodium nitrosylpentacyanoferrate (III), which generate respectively O2- and NO, suggests that these two radicals participate in the induction of TF at the surface of blood monocytes stimulated by LPS.	Oxygen	83-89	coagulation factor III, tissue factor	Homo sapiens	19-21
10502556-7	1999	Increased alveolar-capillary leakage and relative deficiency of SP-B may therefore contribute to oxygen-induced pulmonary dysfunction in SP-B(+/-) mice.	Oxygen	97-103	surfactant associated protein B	Mus musculus	64-68
10502556-7	1999	Increased alveolar-capillary leakage and relative deficiency of SP-B may therefore contribute to oxygen-induced pulmonary dysfunction in SP-B(+/-) mice.	Oxygen	97-103	surfactant associated protein B	Mus musculus	137-141
9483174-5	1997	The restoration of TF expression, in monocytes treated with inhibitors of reactive oxygen production, by N,N"-dimethyl-gamma, gamma"-dipyridylium dichloride and/or sodium nitrosylpentacyanoferrate (III), which generate respectively O2- and NO, suggests that these two radicals participate in the induction of TF at the surface of blood monocytes stimulated by LPS.	Oxygen	232-234	coagulation factor III, tissue factor	Homo sapiens	19-21
25850685-1	2015	The aim of this study was to determine the correlation between angiogenesis and the differential expression of vascular endothelial growth factor (VEGF) and its receptors in myocardial microvascular endothelial cells (MMVECs) co-cultured with mast cells (MCs) or mast cell granules (MCGs) under oxygen and glucose deprivation (OGD).	Oxygen	295-301	vascular endothelial growth factor A	Rattus norvegicus	111-145
25850685-1	2015	The aim of this study was to determine the correlation between angiogenesis and the differential expression of vascular endothelial growth factor (VEGF) and its receptors in myocardial microvascular endothelial cells (MMVECs) co-cultured with mast cells (MCs) or mast cell granules (MCGs) under oxygen and glucose deprivation (OGD).	Oxygen	295-301	vascular endothelial growth factor A	Rattus norvegicus	147-151
9199416-3	1997	Because Trx has been shown to scavenge reactive oxygen species, we have investigated whether the TR-Trx gene product can inhibit oxygen-dependent killing of mycobacteria by human mononuclear phagocytes and as such could contribute to mycobacterial virulence.	Oxygen	48-54	thioredoxin	Homo sapiens	8-11
10568250-6	1999	Air pressure and oxygen partial pressure correspond to an altitude of 2400 meters (8,000 feet) above sea level with possible consequences to the cardiopulmonary system.	Oxygen	17-23	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	101-104
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	35-41	myoglobin	Homo sapiens	65-74
10704992-3	1999	Optimum pH, optimum temperature and K(m)95% was achieved by using 3% (w/v) solution of ceph C, 48 U of DAAO per g of ceph C, keeping dissolved oxygen level above 50%, maintaining the pH between 7.6 and 7.8 and temperature at 24 degrees C. The immobilized DAAO was used for 60 cycles in a stirred tank reactor.	Oxygen	143-149	D-amino acid oxidase	Homo sapiens	103-107
9185169-4	1997	Stimulation of oxygen consumption in the brain slice preparations with either 40 mM KCl by 59.5 +/- 10.3% or 5 microM carbonyl cyanide m-fluorophenyl hydrazone by 61.4 +/- 8.4% increased glutamate C-4 labelling rate constants to 0.058 +/- 0.009 and 0.054 +/- 0.006, respectively.	Oxygen	15-21	complement C4A (Rodgers blood group)	Homo sapiens	197-200
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	35-41	myoglobin	Homo sapiens	76-78
9266588-0	1997	Search for novel leads for histamine H3-receptor antagonists: oxygen-containing derivatives.	Oxygen	62-68	histamine receptor H3	Rattus norvegicus	27-48
9207231-4	1997	Our work shows inhibition of oxygen uptake when cells are transfected with v-myc or H-ras alone.	Oxygen	29-35	HRas proto-oncogene, GTPase	Rattus norvegicus	84-89
9207231-5	1997	However, oxygen uptake increases when cells are transfected simultaneously with v-myc + H-ras (3.7,2.1,2.8).	Oxygen	9-15	HRas proto-oncogene, GTPase	Rattus norvegicus	88-93
9207231-8	1997	The maximum stimulation of oxygen consumption by succinate occurred with v-myc + H-ras transfected cells.	Oxygen	27-33	HRas proto-oncogene, GTPase	Rattus norvegicus	81-86
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	122-126
10462449-1	1999	The TrxRl form of thioredoxin reductase (TrxR) was the major form of the enzyme isolated from HeLa cells grown in a fermentor at 35 degrees C under controlled aeration conditions favorable to growth, nominally 30% of saturation of dissolved oxygen or 8 ml of oxygen in a liter of medium.	Oxygen	241-247	peroxiredoxin 5	Homo sapiens	18-39
10462449-1	1999	The TrxRl form of thioredoxin reductase (TrxR) was the major form of the enzyme isolated from HeLa cells grown in a fermentor at 35 degrees C under controlled aeration conditions favorable to growth, nominally 30% of saturation of dissolved oxygen or 8 ml of oxygen in a liter of medium.	Oxygen	241-247	peroxiredoxin 5	Homo sapiens	4-8
10462449-1	1999	The TrxRl form of thioredoxin reductase (TrxR) was the major form of the enzyme isolated from HeLa cells grown in a fermentor at 35 degrees C under controlled aeration conditions favorable to growth, nominally 30% of saturation of dissolved oxygen or 8 ml of oxygen in a liter of medium.	Oxygen	259-265	peroxiredoxin 5	Homo sapiens	18-39
10462449-1	1999	The TrxRl form of thioredoxin reductase (TrxR) was the major form of the enzyme isolated from HeLa cells grown in a fermentor at 35 degrees C under controlled aeration conditions favorable to growth, nominally 30% of saturation of dissolved oxygen or 8 ml of oxygen in a liter of medium.	Oxygen	259-265	peroxiredoxin 5	Homo sapiens	4-8
10462449-3	1999	At higher aeration, 50% of saturation of dissolved oxygen or 12 ml of oxygen in a liter of medium, HeLa cell growth was slower and additional TrxR forms that bound to heparin were present in purified enzyme preparations.	Oxygen	70-76	peroxiredoxin 5	Homo sapiens	142-146
10596728-7	1999	Serum leptin levels significantly negatively correlated oxygen uptake per body and pulse oxygen per body weight only in rugby players but not in race walkers.	Oxygen	56-62	leptin	Homo sapiens	6-12
10596728-7	1999	Serum leptin levels significantly negatively correlated oxygen uptake per body and pulse oxygen per body weight only in rugby players but not in race walkers.	Oxygen	89-95	leptin	Homo sapiens	6-12
9169434-2	1997	To begin to address this we have examined the effects of oxygen concentration on the expression of several nuclear genes (CYC1, CYC7, COX4, COX5a, COX5b, COX6, COX7, COX8, and COX9) for proteins of the terminal portion of the respiratory chain.	Oxygen	57-63	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	154-158
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	119-121	cytochrome c oxidase subunit VIIa	Saccharomyces cerevisiae S288C	53-57
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	138-144	cytochrome c oxidase subunit VIIa	Saccharomyces cerevisiae S288C	53-57
9169434-8	1997	For others (COX5a and CYC1) the level of expression is nearly constant between 200 microM O2 and their threshold and then drops off.	Oxygen	90-92	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	22-26
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	43-45	myoglobin	Homo sapiens	65-74
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	43-45	myoglobin	Homo sapiens	76-78
9199380-1	1997	Variations in the levels of muscle hemoglobin and of myoglobin oxygen saturation can be detected non-invasively with near-infrared spectroscopy.	Oxygen	63-69	myoglobin	Homo sapiens	53-62
10421675-2	1999	In the non-steady state of moderate intensity exercise, pulmonary O2 uptake (Vp,O2) is temporally dissociated from muscle O2 consumption (Vm,O2) due to the influence of the intervening venous blood volume and the contribution of body O2 stores to ATP synthesis.	Oxygen	66-68	peroxidasin like	Homo sapiens	77-82
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	103-105	myoglobin	Homo sapiens	65-74
10421675-3	1999	A monoexponential model of Vp,O2 without a delay term, therefore, implies an obligatory slowing of Vp,O2 kinetics in comparison to Vm, O2.	Oxygen	30-32	peroxidasin like	Homo sapiens	99-104
25899737-1	2015	Differences between species in the oxygen (O2) affinity (P50) of myoglobin (Mb) may serve to fine tune O2 supply to cardiac and skeletal muscle in ectotherms.	Oxygen	103-105	myoglobin	Homo sapiens	76-78
25899737-3	2015	It is unknown whether similar adaptations exist in the O2 affinity of Mb from reptiles, despite this group of ectothermic vertebrates displaying great variation in the tolerance to both temperature and hypoxia.	Oxygen	55-57	myoglobin	Homo sapiens	70-72
25899737-8	2015	Furthermore, the O2 affinity of turtle Mb is without allosteric control and independent of either lactate or thiol covalent modification.	Oxygen	17-19	myoglobin	Homo sapiens	39-41
9430347-9	1997	Relative changes of the oxygen consumption rate can be estimated from CBF and BOLD changes using FAIR.	Oxygen	24-30	CCAAT enhancer binding protein zeta	Homo sapiens	70-73
10398703-7	1999	Furthermore, when placed in medium devoid of P, the psr1 strains lost photosynthetic O2 evolution and stopped growing more rapidly than wild-type cells; they may not be as efficient as wild-type cells at scavenging/accessing P stores.	Oxygen	85-87	uncharacterized protein	Chlamydomonas reinhardtii	52-56
25921391-2	2015	We showed earlier that genetic deletion of aldose reductase (AR), the rate-limiting enzyme in the polyol pathway, reduced the neovascularization through attenuating oxidative stress induction in the mouse oxygen-induced retinopathy (OIR) modeling ROP.	Oxygen	205-211	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	43-59
10417723-0	1999	Oxygen deprivation stimulates Ca2+-mediated phosphorylation of mRNA cap-binding protein eIF4E in maize roots.	Oxygen	0-6	eukaryotic translation initiation factor 4E-1	Zea mays	88-93
10417723-5	1999	O2 deprivation resulted in a decrease in the isoelectric point of eIF4E, consistent with additional phosphorylation.	Oxygen	0-2	eukaryotic translation initiation factor 4E-1	Zea mays	66-71
9154143-13	1997	scavengers oxygen enhanced radiation-induced double-strand breakage with BSA.	Oxygen	11-17	albumin	Bos taurus	73-76
25921391-2	2015	We showed earlier that genetic deletion of aldose reductase (AR), the rate-limiting enzyme in the polyol pathway, reduced the neovascularization through attenuating oxidative stress induction in the mouse oxygen-induced retinopathy (OIR) modeling ROP.	Oxygen	205-211	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	61-63
9120261-3	1997	Blood leukocytes differentially express two additional IgG FcR, Fc gamma RI (CD64) and Fc gamma RIII (CD16), which may also participate in leukocyte functions such as phagocytosis, Ab-dependent cellular cytotoxicity (ADCC), release of oxygen intermediates, and enhancement of Ag presentation.	Oxygen	235-241	Fc gamma receptor Ia	Homo sapiens	64-75
9120261-3	1997	Blood leukocytes differentially express two additional IgG FcR, Fc gamma RI (CD64) and Fc gamma RIII (CD16), which may also participate in leukocyte functions such as phagocytosis, Ab-dependent cellular cytotoxicity (ADCC), release of oxygen intermediates, and enhancement of Ag presentation.	Oxygen	235-241	Fc gamma receptor Ia	Homo sapiens	77-81
10417723-6	1999	Modification of eIF4E was mimicked by treatment with caffeine under aerobic conditions and blocked by treatment with ruthenium red under O2 deprivation, implicating Ca2+ as a second messenger in eIF4E modification.	Oxygen	137-139	eukaryotic translation initiation factor 4E-1	Zea mays	16-21
10329601-6	1999	Oxygen-induced damage of alveolar epithelium and, unexpectedly, of endothelium was prevented by KGF treatment as seen by electron microscopy.	Oxygen	0-6	fibroblast growth factor 7	Mus musculus	96-99
10329601-7	1999	We investigated the effect of KGF on different mechanisms known to be involved in oxygen toxicity.	Oxygen	82-88	fibroblast growth factor 7	Mus musculus	30-33
10330246-1	1999	We investigated the role of myoglobin (Mb) in supplying O2 to mitochondria during transitions in cardiac workload.	Oxygen	56-58	LOW QUALITY PROTEIN: myoglobin	Oryctolagus cuniculus	28-37
26048361-3	2015	In young Eker rats, an animal model of TSC and autism, which harbors a germ line heterozygous Tsc2 mutation, we previously reported that cerebral oxygen consumption was pronouncedly elevated.	Oxygen	146-152	TSC complex subunit 2	Rattus norvegicus	94-98
10085255-3	1999	Whereas hypoxia prevents proteasomal degradation of HIF-1alpha, ARNT expression is thought to be oxygen-independent.	Oxygen	97-103	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	64-68
9049176-0	1997	Lack of control by immediate early response genes in the oxygen regulation of erythropoietin gene expression.	Oxygen	57-63	erythropoietin	Rattus norvegicus	78-92
9126290-7	1997	VEGF mRNA levels were 10-fold higher in 3% O2-treated explants than in 20% O2-treated explants.	Oxygen	43-45	vascular endothelial growth factor A	Rattus norvegicus	0-4
26146957-1	2015	Using first-principles local and hybrid density functional theoretical calculations, a thickness-dependent electronic structure of layered GaS is determined, and it is shown that 2D GaS has an electronic structure with valence and conduction bands that straddle the redox potentials of hydrogen evolution reaction and oxygen evolution reaction up to a critical thickness (&lt;5.5 nm).	Oxygen	318-324	gastrin	Homo sapiens	182-185
9126290-7	1997	VEGF mRNA levels were 10-fold higher in 3% O2-treated explants than in 20% O2-treated explants.	Oxygen	75-77	vascular endothelial growth factor A	Rattus norvegicus	0-4
9126290-8	1997	Addition of anti-VEGF antibodies to 3% O2-treated explants prevented low oxygen-induced growth and endothelial cell differentiation and proliferation.	Oxygen	39-41	vascular endothelial growth factor A	Rattus norvegicus	17-21
9126290-8	1997	Addition of anti-VEGF antibodies to 3% O2-treated explants prevented low oxygen-induced growth and endothelial cell differentiation and proliferation.	Oxygen	73-79	vascular endothelial growth factor A	Rattus norvegicus	17-21
9126290-10	1997	Upregulation of VEGF expression by low oxygen and prevention of low oxygen-induced tubulogenesis and vasculogenesis by anti-VEGF antibodies indicate that these changes were mediated by VEGF.	Oxygen	39-45	vascular endothelial growth factor A	Rattus norvegicus	16-20
9126290-10	1997	Upregulation of VEGF expression by low oxygen and prevention of low oxygen-induced tubulogenesis and vasculogenesis by anti-VEGF antibodies indicate that these changes were mediated by VEGF.	Oxygen	68-74	vascular endothelial growth factor A	Rattus norvegicus	124-128
9126290-10	1997	Upregulation of VEGF expression by low oxygen and prevention of low oxygen-induced tubulogenesis and vasculogenesis by anti-VEGF antibodies indicate that these changes were mediated by VEGF.	Oxygen	68-74	vascular endothelial growth factor A	Rattus norvegicus	124-128
10079260-6	1999	In situ hybridization revealed that VEGF was highly expressed in distal airway epithelial cells in controls but disappeared in the oxygen-exposed animals.	Oxygen	131-137	vascular endothelial growth factor A	Rattus norvegicus	36-40
10079260-10	1999	We speculate that VEGF functions as a survival factor in the normal adult rat lung, and its loss during hyperoxia contributes to the pathophysiology of oxygen-induced lung damage.	Oxygen	152-158	vascular endothelial growth factor A	Rattus norvegicus	18-22
9027719-1	1997	There is accumulating evidence from in vitro studies suggesting that the genes of endothelin-1, PDGF, and VEGF are, like the erythropoietin gene, regulated by oxygen tension and by divalent cations.	Oxygen	159-165	vascular endothelial growth factor A	Rattus norvegicus	106-110
10080486-5	1999	RESULTS: In group 1, O2 decreased pulmonary vascular resistance (PVR) (mean+/-SEM) from 17.2+/-2.1 U.m2 to 11.1+/-1.5 U.m2 (p &lt; 0.05).	Oxygen	21-23	PVR cell adhesion molecule	Homo sapiens	65-68
26305684-9	2015	The results showed that r-irisin, in a certain concentration rage, could activate PI3K-AKT and intracellular Ca2+ signaling and increase cellular oxygen consumption in H9C2 cells.	Oxygen	146-152	fibronectin type III domain containing 5	Homo sapiens	26-32
10080486-7	1999	In group 2, PVR decreased from 20.1+/-2.6 U.m2 to 14.3+/-1.9 U.m2 in O2 (p &lt; 0.05) and further to 10.5+/-1.7 U.m2 in NO+O2 (p &lt; 0.05).	Oxygen	69-71	PVR cell adhesion molecule	Homo sapiens	12-15
10080486-7	1999	In group 2, PVR decreased from 20.1+/-2.6 U.m2 to 14.3+/-1.9 U.m2 in O2 (p &lt; 0.05) and further to 10.5+/-1.7 U.m2 in NO+O2 (p &lt; 0.05).	Oxygen	123-125	PVR cell adhesion molecule	Homo sapiens	12-15
10080486-8	1999	A response of 20% or more reduction in PVR was seen in 22/25 patients with NO+O2 compared with 16/25 in O2 alone (p = 0.01).	Oxygen	78-80	PVR cell adhesion molecule	Homo sapiens	39-42
10080486-8	1999	A response of 20% or more reduction in PVR was seen in 22/25 patients with NO+O2 compared with 16/25 in O2 alone (p = 0.01).	Oxygen	104-106	PVR cell adhesion molecule	Homo sapiens	39-42
9027719-1	1997	There is accumulating evidence from in vitro studies suggesting that the genes of endothelin-1, PDGF, and VEGF are, like the erythropoietin gene, regulated by oxygen tension and by divalent cations.	Oxygen	159-165	erythropoietin	Rattus norvegicus	125-139
9027719-3	1997	Hypoxia (8% O2) for six hours caused a 55-fold/1.6-fold increase of renal erythropoietin/endothelin-1 gene expression, whereas endothelin-3, PDGF-A, PDGF-B, and VEGF gene expression was unchanged.	Oxygen	12-14	erythropoietin	Rattus norvegicus	74-88
9027720-1	1997	This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo.	Oxygen	99-105	erythropoietin	Rattus norvegicus	38-41
9027720-1	1997	This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo.	Oxygen	99-105	vascular endothelial growth factor A	Rattus norvegicus	52-56
9027726-11	1997	In these cells, cytochrome b558 as part of an NADPH oxidase may be involved in a presumptive oxygen sensing mechanism using H2O2 as a possible second messenger for EPO gene regulation.	Oxygen	93-99	erythropoietin	Rattus norvegicus	164-167
9027741-3	1997	The results demonstrate that the presence of ARNT is indispensable for hypoxia-inducible HIF-1 DNA binding as well as for oxygen-regulated reporter gene activity mediated by the EPO 3" hypoxia response element (HRE).	Oxygen	122-128	aryl hydrocarbon receptor nuclear translocator	Mus musculus	45-49
9083641-2	1997	In each approach, mammalian myoglobin (Mb) has been used as a prototype to develop experimental methodologies and to study the stereochemical mechanisms that govern O2 affinity, discrimination against CO, rates of ligand binding, auto- and chemically induced oxidation, resistance to hemin loss, and stability to globin denaturation.	Oxygen	165-167	myoglobin	Homo sapiens	28-37
10193577-8	1999	Benzene metabolite"s enhancement of growth of myeloid cells through an active oxygen mechanism may be involved in a number of aspects of benzene toxicity, including enhanced granulocytic growth and differentiation, stimulation of GM-CSF-induced colony formation, apoptosis inhibition, and stimulation of progenitor cell mitogenesis in the bone marrow.	Oxygen	78-84	colony stimulating factor 2	Homo sapiens	230-236
9916047-4	1999	Zymosan, which is composed of alpha-mannan and beta-glucan, was internalized by the MR and a beta-glucan receptor, but the production of O2- was triggered only by phagocytosis through the beta-glucan receptor.	Oxygen	137-139	C-type lectin domain containing 7A	Homo sapiens	188-208
26214018-9	2015	The sulfhydryl oxidase Erv1 generates the disulfide pairs de novo using either molecular oxygen or, cytochrome c and other proteins as terminal electron acceptors that eventually link this folding process to respiration.	Oxygen	89-95	growth factor, augmenter of liver regeneration	Homo sapiens	23-27
10499107-0	1999	On the significance of hydrogen bonds for the discrimination between CO and O2 by myoglobin.	Oxygen	76-78	myoglobin	Homo sapiens	82-91
9890965-0	1999	Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.	Oxygen	0-6	endothelial PAS domain protein 1	Homo sapiens	48-73
9890965-7	1999	Sequences lying C-terminal to this internal domain conveyed repression and oxygen-regulated activity on the native EPAS1 C-terminal activation domain, but not the Gal/VP16 fusion.	Oxygen	75-81	endothelial PAS domain protein 1	Homo sapiens	115-120
9222437-5	1996	The key to successful transitions in several systems is the induction, during the oxygen-limited state, of elevated activities of antioxidant and associated enzymes, such as catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase, so that damage during the reintroduction of oxygen (such as lipid peroxidation) is minimized.	Oxygen	82-88	glutathione S-transferase kappa 1	Homo sapiens	206-231
26084697-1	2015	Predicated on evidence that diving-related microparticle generation is an oxidative stress response, this study investigated the role that oxygen plays in augmenting production of annexin V-positive microparticles associated with open-water SCUBA diving and whether elevations can be abrogated by ascorbic acid.	Oxygen	139-145	annexin A5	Homo sapiens	180-189
8943479-7	1996	In ARF rats exposed to 7.5% O2 for four hours, right kidney Epo mRNA increased 200-fold over normoxic levels, to a value similar to sham-operated hypoxic controls.	Oxygen	28-30	erythropoietin	Rattus norvegicus	60-63
8943479-11	1996	In the post-ischemic kidney, a substantial capacity for Epo production is retained but the sensitivity of the Epo response to blood oxygen availability is significantly reduced.	Oxygen	132-138	erythropoietin	Rattus norvegicus	110-113
10761639-4	1999	Total lung elastin mRNA increased 70-80-fold on d10-14 after BHT/O2, but was unchanged after BHT or O2 alone.	Oxygen	65-67	elastin	Mus musculus	11-18
26153718-1	2015	In this paper, a novel electrochemiluminescence resonance energy transfer (ECL-RET) system from O2/S2O8(2-) to a kind of amino-terminated perylene derivative (PTC-NH2) was demonstrated for the first time, which was then applied to construct a ratiometric aptasensor for lead ion (Pb(2+)) detection.	Oxygen	96-98	ret proto-oncogene	Homo sapiens	79-82
9888440-2	1999	METHODS: Rhodopsin was extracted from whole retinas, the thickness of the rod outer segment (ROS) layer was measured, large phagosomes were counted, and the ROS ultrastructure was examined in the retinas of oxygen-exposed and control rats, ages 13 and 18 days.	Oxygen	207-213	rhodopsin	Rattus norvegicus	9-18
9888440-9	1999	The rhodopsin absorbances of the oxygen-exposed ROS were significantly more variable and higher than in the control rats.	Oxygen	33-39	rhodopsin	Rattus norvegicus	4-13
9116701-1	1996	Anticardiolipin antibodies (aCL) were found to recognize beta 2glycoprotein I (beta 2GPI) structure altered by its interaction with an oxygen modified solid phase surface by gamma-ray radiation.	Oxygen	135-141	apolipoprotein H	Homo sapiens	57-77
9116701-1	1996	Anticardiolipin antibodies (aCL) were found to recognize beta 2glycoprotein I (beta 2GPI) structure altered by its interaction with an oxygen modified solid phase surface by gamma-ray radiation.	Oxygen	135-141	apolipoprotein H	Homo sapiens	79-88
26196211-12	2015	The singlet oxygen ((1)O2) photosensitizing of Pt-1 was improved as compared to the complexes containing only a single visible-light-absorbing chromophore.	Oxygen	20-25	zinc finger protein 77	Homo sapiens	47-51
8922233-8	1996	The above data indicated that NRC delivered sufficient oxygen to tissues, substituting for circulating red cells and maintained aerobic metabolism.	Oxygen	55-61	nuclear receptor coactivator 6	Homo sapiens	30-33
9888442-8	1999	In mice with oxygen-induced ischemic retinopathy, HIF-1alpha levels were increased in the retina.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	50-60
25940829-5	2015	Fructose 1,6-bisphosphate, ADP and PEP stimulated the oxidation of ferrous ion causing one-electron reduction of oxygen molecule.	Oxygen	113-119	progestagen associated endometrial protein	Homo sapiens	35-38
14530946-0	1999	Role of reactive oxygen in phospholipase A2 activation by ischemia/reperfusion of the rat kidney.	Oxygen	17-23	phospholipase A2 group IB	Rattus norvegicus	27-43
14530946-6	1999	Renal mitochondrial PLA(2) activity was further augmented by hyperbaric oxygen exposure prior to reperfusion, whereas administration of the ROS scavengers suppressed mitochondrial PLA(2) activity.	Oxygen	72-78	phospholipase A2 group IB	Rattus norvegicus	20-26
8873591-5	1996	For the 17 residue neuromodulin derived peptide, which is Ca2+ independent in its binding to calmodulin, oxygen collision rates demonstrate that one helical face of this peptide interacts strongly with calmodulin.	Oxygen	105-111	growth associated protein 43	Homo sapiens	19-31
8897823-2	1996	In this study, we have quantitated HIF-1 DNA-binding activity and protein levels of the HIF-1 alpha and HIF-1 beta subunits in human HeLa cells exposed to O2 concentrations ranging from 0 to 20% in the absence or presence of 1 mM KCN to inhibit oxidative phosphorylation and cellular O2 consumption.	Oxygen	155-157	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	104-114
26037477-0	2015	Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta.	Oxygen	45-51	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-35
8859080-5	1996	RESULTS: The inner nuclear layer of oxygen-exposed retinas exhibited a continuous intense band of VPF/VEGF messenger RNA expression across the peripheral avascular zone that dropped sharply in vascular retina.	Oxygen	36-42	vascular endothelial growth factor A	Rattus norvegicus	98-101
8859080-5	1996	RESULTS: The inner nuclear layer of oxygen-exposed retinas exhibited a continuous intense band of VPF/VEGF messenger RNA expression across the peripheral avascular zone that dropped sharply in vascular retina.	Oxygen	36-42	vascular endothelial growth factor A	Rattus norvegicus	102-106
8813114-8	1996	We propose that the ability of activated c-Myc to enhance cellular proliferation might contribute to the genesis of early neoplasms that are held in check by the alternate ability of c-Myc to induce apoptosis of cells that have outgrown their supply of oxygen or other factors associated with hypoxic regions of solid tumors.	Oxygen	253-259	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
8813114-8	1996	We propose that the ability of activated c-Myc to enhance cellular proliferation might contribute to the genesis of early neoplasms that are held in check by the alternate ability of c-Myc to induce apoptosis of cells that have outgrown their supply of oxygen or other factors associated with hypoxic regions of solid tumors.	Oxygen	253-259	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	183-188
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Oxygen	170-176	complement C4A (Rodgers blood group)	Homo sapiens	137-140
9874706-2	1999	In the presence of 15 000 ppm (1.5%) residual oxygen, ascorbate/oxygen-mediated reactions resulted in an increased rate of autoxidation, modification of the beta-globin, increased oxygen affinity and decreased maximum Hill coefficient.	Oxygen	46-52	hemoglobin subunit beta	Homo sapiens	157-168
9874706-2	1999	In the presence of 15 000 ppm (1.5%) residual oxygen, ascorbate/oxygen-mediated reactions resulted in an increased rate of autoxidation, modification of the beta-globin, increased oxygen affinity and decreased maximum Hill coefficient.	Oxygen	64-70	hemoglobin subunit beta	Homo sapiens	157-168
9874706-2	1999	In the presence of 15 000 ppm (1.5%) residual oxygen, ascorbate/oxygen-mediated reactions resulted in an increased rate of autoxidation, modification of the beta-globin, increased oxygen affinity and decreased maximum Hill coefficient.	Oxygen	64-70	hemoglobin subunit beta	Homo sapiens	157-168
9838202-8	1998	Exposure of piglet glial cells to lower than normal O2 increased the release of both opioids (503+/-61 vs. 1488+/-186 pg/mg protein methionine enkephalin before and after hypoxia, (PO2 approximately 15 mmHg).	Oxygen	52-54	proenkephalin	Sus scrofa	143-153
9836521-3	1998	In this study, we examined the gene expression of VEGF mRNA in three tumor cell lines and in isolated whole and dispersed rat islets in vitro by Northern blot hybridization in normoxic (5% CO2, 95% humidified air) and hypoxic (1% O2, 5% CO2, 94% N2) culture conditions.	Oxygen	190-192	vascular endothelial growth factor A	Rattus norvegicus	50-54
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Oxygen	170-176	complement C5	Homo sapiens	146-149
26037477-4	2015	JMJD6 expression inversely correlated with changes in oxygen tension during early placental development, ie, high at 7-9 weeks when-partial pressure of O2 is low and declining afterwards when-partial pressure of O2 increases.	Oxygen	54-60	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
10052659-3	1998	During ischaemia at rest, the fall in NIRS-O2 was more pronounced [76 (SEM 3) to 3 (SEM 1)%] than in SvO2 [71 (SEM 3) to 59 (SEM 2)%].	Oxygen	43-45	SEM1 26S proteasome subunit	Homo sapiens	84-89
26037477-4	2015	JMJD6 expression inversely correlated with changes in oxygen tension during early placental development, ie, high at 7-9 weeks when-partial pressure of O2 is low and declining afterwards when-partial pressure of O2 increases.	Oxygen	152-154	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
8902878-5	1996	Changes in oxygen tension augment the Na(+)-transporting capacity of the epithelium and increase gene expression for the epithelial Na+ channel (ENaC).	Oxygen	11-17	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	145-149
26037477-4	2015	JMJD6 expression inversely correlated with changes in oxygen tension during early placental development, ie, high at 7-9 weeks when-partial pressure of O2 is low and declining afterwards when-partial pressure of O2 increases.	Oxygen	212-214	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
26037477-6	2015	Exposure of primary isolated trophoblast cells, human villous explants, and JEG3 choriocarcinoma cells to low oxygen (3%) and sodium nitroprusside (inducer of oxidative stress) also resulted in elevated JMJD6 levels, which was abrogated by HIF1A knockdown.	Oxygen	110-116	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	203-208
10065035-7	1998	His right heart pressures were reassessed showing a pronounced reduction in pulmonary artery pressure and a significant reduction in PVR, which fell further with inhaled oxygen and sublingual nitrates.	Oxygen	170-176	PVR cell adhesion molecule	Homo sapiens	133-136
26037477-10	2015	In summary, our data signify a novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia.	Oxygen	58-64	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	46-51
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	72-78	interleukin 1 alpha	Homo sapiens	17-26
26012551-1	2015	Erythropoietin (Epo) is produced in the kidney and liver in a hypoxia-inducible manner via the activation of hypoxia-inducible transcription factors (HIFs) to maintain oxygen homeostasis.	Oxygen	168-174	erythropoietin	Mus musculus	0-14
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	108-110	interleukin 1 alpha	Homo sapiens	17-26
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	139-145	interleukin 1 alpha	Homo sapiens	17-26
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	139-145	interleukin 1 alpha	Homo sapiens	172-181
8702551-9	1996	Mn-SOD overexpression and low oxygen alter IL-1alpha mRNA levels by decreasing the stability of the IL-1alpha mRNA.	Oxygen	30-36	interleukin 1 alpha	Homo sapiens	43-52
8702551-9	1996	Mn-SOD overexpression and low oxygen alter IL-1alpha mRNA levels by decreasing the stability of the IL-1alpha mRNA.	Oxygen	30-36	interleukin 1 alpha	Homo sapiens	100-109
9869033-1	1998	Reflectance spectrometry is a useful tool for studying in vivo kinetic changes in the oxygen saturation of haemoglobin and myoglobin as well as the redox state of cytochromes.	Oxygen	86-92	myoglobin	Cavia porcellus	123-132
9828111-0	1998	Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen.	Oxygen	129-135	serpin family E member 1	Homo sapiens	15-48
9828111-4	1998	In this study, we used immortalized human trophoblasts (HTR-8/SVneo cells) derived from first trimester placenta to study the effect of exposure to low levels of oxygen on PAI-1 expression.	Oxygen	162-168	serpin family E member 1	Homo sapiens	172-177
9828111-10	1998	These results indicate that, through their effect on PAI-1 expression, oxygen levels may play an important role in modulating cellular migration and invasion.	Oxygen	71-77	serpin family E member 1	Homo sapiens	53-58
9822602-1	1998	In response to decreased cellular oxygen concentrations the basic helix-loop-helix (bHLH)/PAS (Per, Arnt, Sim) hypoxia-inducible transcription factor, HIF-1alpha, mediates activation of networks of target genes involved in angiogenesis, erythropoiesis and glycolysis.	Oxygen	34-40	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	100-104
8702551-10	1996	These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF-induced IL-1alpha expression, presumably superoxide.	Oxygen	45-47	interleukin 1 alpha	Homo sapiens	133-142
9297300-0	1996	[Role of myoglobin in supplying oxygen to tissues].	Oxygen	32-38	myoglobin	Homo sapiens	9-18
9297300-1	1996	The functional properties and role of myoglobin in oxygen-supplying system of tissues are discussed on the basis of literature data.	Oxygen	51-57	myoglobin	Homo sapiens	38-47
9297300-2	1996	The mechanisms of myoglobin participation in conservation and intracellular transport of oxygen, as well as its antioxidase, monooxygenase and peroxidase activity are considered.	Oxygen	89-95	myoglobin	Homo sapiens	18-27
26012551-1	2015	Erythropoietin (Epo) is produced in the kidney and liver in a hypoxia-inducible manner via the activation of hypoxia-inducible transcription factors (HIFs) to maintain oxygen homeostasis.	Oxygen	168-174	erythropoietin	Mus musculus	16-19
9972455-4	1998	However, the relatively high capacity of the monooxygenase system in sea stars to catalyse reactions with organic hydroperoxide as donor for activated oxygen, and the low induceability during exposure to xenobiotics indicate also important differences between the echinoderm cytochrome P450 monooxygenase system and that of vertebrates.	Oxygen	49-55	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	275-304
26178114-1	2015	In low dimensional cesium silicate LDS-1 (monoclinic phase of CsHSi2O5), anomalous infrared absorption bands observed at 93, 155, 1210, and 1220 cm(-1) are assigned to the vibrational mode of protons, which contribute to the strong hydrogen bonding between terminal oxygen atoms of silicate chain (O-O distance = 2.45 A).	Oxygen	266-272	transforming growth factor beta receptor 1	Homo sapiens	35-40
9876984-13	1998	CONCLUSION: These data demonstrate an influence of NO on LPS-induced TF expression in monocytes by prior formation of peroxynitrite; furthermore, the balance between NO and O2- seems to play a crucial role.	Oxygen	173-175	coagulation factor III, tissue factor	Homo sapiens	69-71
8663160-3	1996	The intensity of the ESR spectrum corresponding to the DBNBS/*cytochrome c radical adduct was greatly enhanced by performing the reaction under anaerobic conditions, which suggested that the spin trap was competing with O2 for reaction with the radical site(s).	Oxygen	220-222	cytochrome c, somatic	Equus caballus	62-74
25953442-11	2015	CONCLUSIONS: We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC.	Oxygen	84-90	SRY-box transcription factor 17	Homo sapiens	48-53
8662480-2	1996	Oxygen isotope measurements indicate that the growth of continental ice sheets caused these rapid sea level changes.	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
9781467-1	1998	OBJECTIVES: To determine oxygen metabolism, permeability, and blood flow in isolated joints in response to interleukin 1beta (IL-1beta) and contribution of innervation.	Oxygen	25-31	interleukin-1 beta	Equus caballus	126-134
25912138-4	2015	Enhanced expression of HIF2A mRNA at hypoxia is due to de novo transcription rather than increased mRNA stability, and chemical stabilization of the HIF-alpha proteins at oxygen-rich conditions unexpectedly leads to increased HIF2A transcription.	Oxygen	171-177	endothelial PAS domain protein 1	Homo sapiens	226-231
9893946-8	1998	These results suggest that the expression of mitochondrial encoded subunits (CO-I, CO-II and F0F1-ATPase 6) is up-regulated in response to oxygen and NO reactive species.	Oxygen	139-145	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	77-81
8691427-7	1996	Dehydration of 1 to 2-deoxy-2(13)-dehydro-1 allows the restoration of oxygen at C-2 by conversion to epoxides or a diol.	Oxygen	70-76	complement C2	Homo sapiens	80-83
8797276-0	1996	Casein effects on the myeloperoxidase-mediated oxygen-dependent bactericidal activity of bovine neutrophils.	Oxygen	47-53	myeloperoxidase	Bos taurus	22-37
25796140-4	2015	Hypoxia Inducible Factor (HIF)1alpha and HIF2alpha are transcription factors regulated by cellular oxygen concentration that initiate gene regulation of vascular development, redox homeostasis, and cell cycle control.	Oxygen	99-105	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-36
9747510-0	1998	Oxygen tension regulates heme oxygenase-1 gene expression in mammalian cell lines.	Oxygen	0-6	heme oxygenase 1	Homo sapiens	25-41
9747510-10	1998	These results indicate that oxygen tension regulates HO-1 gene expression and suggest that hyperoxia-specific and redox-sensitive regulators may be involved in hyperoxia-mediated HO-1 gene expression.	Oxygen	28-34	heme oxygenase 1	Homo sapiens	53-57
9747510-10	1998	These results indicate that oxygen tension regulates HO-1 gene expression and suggest that hyperoxia-specific and redox-sensitive regulators may be involved in hyperoxia-mediated HO-1 gene expression.	Oxygen	28-34	heme oxygenase 1	Homo sapiens	179-183
8601644-0	1996	Three alternative promoters of the rat gamma-glutamyl transferase gene are active in developing lung and are differentially regulated by oxygen after birth.	Oxygen	137-143	gamma-glutamyltransferase 1	Rattus norvegicus	39-65
25796140-4	2015	Hypoxia Inducible Factor (HIF)1alpha and HIF2alpha are transcription factors regulated by cellular oxygen concentration that initiate gene regulation of vascular development, redox homeostasis, and cell cycle control.	Oxygen	99-105	endothelial PAS domain protein 1	Mus musculus	41-50
25796140-5	2015	HIF1alpha and HIF2alpha contribute to important adaptive mechanisms that occur when oxygen and ROS homeostasis become unbalanced.	Oxygen	84-90	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
9745432-9	1998	Leptin secretion was increased significantly in a human trophoblastic cell line (BeWo cells) cultured under hypoxic conditions (5% O2), compared with those cultured under standard conditions (20% O2; P &lt; 0.01).	Oxygen	131-133	leptin	Homo sapiens	0-6
25796140-5	2015	HIF1alpha and HIF2alpha contribute to important adaptive mechanisms that occur when oxygen and ROS homeostasis become unbalanced.	Oxygen	84-90	endothelial PAS domain protein 1	Mus musculus	14-23
9745432-9	1998	Leptin secretion was increased significantly in a human trophoblastic cell line (BeWo cells) cultured under hypoxic conditions (5% O2), compared with those cultured under standard conditions (20% O2; P &lt; 0.01).	Oxygen	196-198	leptin	Homo sapiens	0-6
33863134-8	1996	Measurements of in vivo chlorophyll-fluorescence induction kinetics showed that the decline in Asat induced by elevated CO2 , and/or O2 , was not associated with significant changes in the photochemical efficiency of photosystem (PS) II.	Oxygen	121-123	ATP binding cassette subfamily B member 7	Homo sapiens	95-99
25701705-5	2015	Using recombinant enzymes and isolated permeabilized cardiac mitochondria, we show that two normally antioxidant matrix NADPH reductases, glutathione reductase and thioredoxin reductase, generate H2O2 by leaking electrons from their reduced flavoprotein to O2 when electron flow is impaired by inhibitors or because of limited availability of their natural electron acceptors, GSSG and oxidized thioredoxin.	Oxygen	198-200	thioredoxin	Homo sapiens	164-175
8611164-5	1996	The data provide the first evidence for a ternary complex comprising peroxidase, IAA and oxygen that is kinetically competent both at the initiation stage and during the catalytic cycle of IAA oxidation.	Oxygen	89-95	peroxidase N1	Nicotiana tabacum	69-79
8635551-0	1996	Microtubule-associated protein 2 expressing COS7 cells are resistant to argyrophilia under oxygen- and glucose-free condition.	Oxygen	91-97	microtubule-associated protein 2	Rattus norvegicus	0-32
9694504-5	1998	The effects of TPO, EPO, and G-CSF on Mks, erythrocytes, and granulocytes, respectively, were dependent on the O2 tension.	Oxygen	111-113	colony stimulating factor 3	Homo sapiens	29-34
9694504-9	1998	In contrast, approximately twice as many CD15+ cells were produced in G-CSF-containing cultures under 5% vs. 20%) O2.	Oxygen	114-116	colony stimulating factor 3	Homo sapiens	70-75
9694504-10	1998	The numbers of CFU-Mk in TPO-containing and CFU-GM in G-CSF-containing cultures were larger under 5% O2.	Oxygen	101-103	colony stimulating factor 3	Homo sapiens	54-59
9694504-12	1998	Our data also suggest that TPO, EPO, and G-CSF elicit stimulatory cross-lineage effects in the presence of IL-3 and SCF, and that these effects, too, are often dependent on O2 tension.	Oxygen	173-175	colony stimulating factor 3	Homo sapiens	41-46
9677418-2	1998	Exposure to physiological levels of hypoxia (5% O2, approximately 50 mm Hg) rapidly induced a persistent phosphorylation of CREB on Ser133, an event that is required for CREB-mediated transcriptional activation.	Oxygen	48-50	cAMP responsive element binding protein 1	Rattus norvegicus	124-128
9677418-2	1998	Exposure to physiological levels of hypoxia (5% O2, approximately 50 mm Hg) rapidly induced a persistent phosphorylation of CREB on Ser133, an event that is required for CREB-mediated transcriptional activation.	Oxygen	48-50	cAMP responsive element binding protein 1	Rattus norvegicus	170-174
9677418-6	1998	Thus, a physiological reduction in O2 levels induces a functional phosphorylation of CREB at Ser133 via a novel signaling pathway.	Oxygen	35-37	cAMP responsive element binding protein 1	Rattus norvegicus	85-89
8603833-10	1996	CONCLUSIONS: Regulation of VEGF by tissue oxygen mediates the inhibition of vessel growth during hyperoxia and the subsequent proliferative vasculopathy.	Oxygen	42-48	vascular endothelial growth factor A	Felis catus	27-31
8603849-0	1996	Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation.	Oxygen	0-6	epidermal growth factor	Homo sapiens	102-125
25701705-5	2015	Using recombinant enzymes and isolated permeabilized cardiac mitochondria, we show that two normally antioxidant matrix NADPH reductases, glutathione reductase and thioredoxin reductase, generate H2O2 by leaking electrons from their reduced flavoprotein to O2 when electron flow is impaired by inhibitors or because of limited availability of their natural electron acceptors, GSSG and oxidized thioredoxin.	Oxygen	198-200	thioredoxin	Homo sapiens	395-406
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Oxygen	223-229	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
8720507-2	1996	The mechanism underlying A beta neurotoxicity may include an increase in intracellular calcium and reactive oxygen species.	Oxygen	108-114	amyloid beta (A4) precursor protein	Mus musculus	25-31
10838287-0	1998	Normative oxygen saturation values for pregnant women at sea level.	Oxygen	10-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Oxygen	223-229	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	163-168
9649340-8	1998	This may indicate that the resting form of ceruloplasmin in plasma under aerobic conditions is a four-electron oxidized form, which is consistent with its function in the four-electron reduction of dioxygen to water.	Oxygen	198-206	ceruloplasmin	Homo sapiens	43-56
25829424-7	2015	Thus, in addition to promoting ccRCC proliferation and anabolic metabolism, HIF2alpha modulates lipid storage to sustain ER homeostasis, particularly under conditions of nutrient and oxygen limitation, thereby promoting tumor cell survival.	Oxygen	183-189	endothelial PAS domain protein 1	Homo sapiens	76-85
17029711-0	1998	Anaerobic stopped-flow studies of indole-3-acetic acid oxidation by dioxygen catalysed by horseradish C and anionic tobacco peroxidase at neutral pH: catalase effect.	Oxygen	68-76	lignin-forming anionic peroxidase-like	Nicotiana tabacum	124-134
17029711-1	1998	The effect of order of reagent mixing in the absence and in the presence of catalase on the transient kinetics of indole-3-acetic acid (IAA) oxidation by dioxygen catalysed by horseradish peroxidase C and anionic tobacco peroxidase at neutral pH has been studied.	Oxygen	154-162	lignin-forming anionic peroxidase-like	Nicotiana tabacum	188-198
8558813-7	1996	However the PVR decreased from 9.6 to 3.6 woodunits.m2 after inspiration of 100% oxygen.	Oxygen	81-87	PVR cell adhesion molecule	Homo sapiens	12-15
25940738-2	2015	Wheresas oxygen-atom transfer prevails in the reaction of the oxide complex [OTiH](+) with CO2 , generating [OTi(OH)](+) under the elimination of CO, insertion of CO2 into the metal-hydrogen bond of the cyclopentadienyl complex, [Cp2 TiH](+) , gives rise to the formate complex [Cp2 Ti(O2 CH)](+) .	Oxygen	9-15	ceruloplasmin	Homo sapiens	230-233
7493931-3	1995	The glucose transporter Glut-1 is induced by both hypoxia and mitochondrial inhibitors, implying the operation of a different mechanism of oxygen sensing.	Oxygen	139-145	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	24-30
17029711-1	1998	The effect of order of reagent mixing in the absence and in the presence of catalase on the transient kinetics of indole-3-acetic acid (IAA) oxidation by dioxygen catalysed by horseradish peroxidase C and anionic tobacco peroxidase at neutral pH has been studied.	Oxygen	154-162	lignin-forming anionic peroxidase-like	Nicotiana tabacum	221-231
25940738-2	2015	Wheresas oxygen-atom transfer prevails in the reaction of the oxide complex [OTiH](+) with CO2 , generating [OTi(OH)](+) under the elimination of CO, insertion of CO2 into the metal-hydrogen bond of the cyclopentadienyl complex, [Cp2 TiH](+) , gives rise to the formate complex [Cp2 Ti(O2 CH)](+) .	Oxygen	9-15	ceruloplasmin	Homo sapiens	279-282
7493931-8	1995	Thus, rather than reflecting an entirely different mechanism of oxygen sensing, regulation of Glut-1 gene expression by hypoxia and mitochondrial inhibitors arises from the function of two different sensing systems.	Oxygen	64-70	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	94-100
25471928-0	2015	Oxygen-dependent copper toxicity: targets in the chlorophyll biosynthesis pathway identified in the copper efflux ATPase CopA deficient mutant.	Oxygen	0-6	COPI coat complex subunit alpha	Homo sapiens	121-125
7587805-3	1995	Aspirin-induced gastric damage and the increase in myeloperoxidase activity were significantly inhibited by the injection of anti-CD11a, anti-CD11b, anti-intercellular adhesion molecule-1 monoclonal antibodies, and the combination of superoxide dismutase and catalase, which are scavengers of active oxygen species.	Oxygen	300-306	myeloperoxidase	Rattus norvegicus	51-66
8647512-3	1995	The present study was thus designed to investigate EPO production during acute hypoxemia in a mouse model in which the oxygen-carrying capacity of blood, the plasma EPO level, the blood viscosity and the plasma EPO half-life are within normal values in spite of an intense stimulation of erythropoiesis.	Oxygen	119-125	erythropoietin	Mus musculus	51-54
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Oxygen	146-152	interferon gamma	Rattus norvegicus	80-105
9626179-0	1998	Induction of plasminogen activator inhibitor type 1 and type 1 collagen expression in rat cardiac microvascular endothelial cells by interleukin-1 and its dependence on oxygen-centered free radicals.	Oxygen	169-175	serpin family E member 2	Rattus norvegicus	13-51
9626179-10	1998	CONCLUSIONS: These results indicate that IL-1-induced oxygen-centered free radicals stimulate elaboration of PAI-1 and collagen by CMECs.	Oxygen	54-60	serpin family E member 2	Rattus norvegicus	109-114
10684005-6	1998	These suggest that both FNZ and Vit C reduce reperfusion injury through suppression of myocardium calcium overload and oxygen free radical damage.	Oxygen	119-125	vitrin	Rattus norvegicus	32-35
9692515-5	1998	There was evidence of an increase in mPAP, MDA, PAF and ET-1 in the plasma, and activity of PLA2, PAF and ET-1 of the lung tissues when the rats inhaled a 10% mixture of oxygen in nitrogen.	Oxygen	170-176	phospholipase A2 group IB	Rattus norvegicus	92-96
25471928-1	2015	Characterization of a copA(-) mutant in the purple photosynthetic bacterium Rubrivivax gelatinosus under low oxygen or anaerobic conditions, as well as in the human pathogen Neisseria gonorrhoeae identified HemN as a copper toxicity target enzyme in the porphyrin synthesis pathway.	Oxygen	109-115	COPI coat complex subunit alpha	Homo sapiens	22-26
9609576-4	1998	RESULTS: Using analysis of variance with repeated measures from pregravid to late pregnancy, a 66% increase (mean +/- SD) was found in leptin concentrations (in nanograms per milliliter) (before pregnancy, 25.4 +/- 19.9; in early pregnancy, 37.5 +/- 26.2; and in late pregnancy, 38.4 +/- 27.3, p = 0.003); a 9% increase in body fat (in kilograms) (before pregnancy, 29.4 +/- 15.7; in early pregnancy, 28.7 +/- 14.0; in late pregnancy, 31.4 +/- 14.6; p = 0.04); a 28% increase in oxygen consumption (in milliliters of oxygen per minute) (before pregnancy, 221.2 +/- 29.5; in early pregnancy, 230.4 +/- 42.9; in late pregnancy, 285.3 +/- 51.9; p &lt; 0.0001); and a 9% increase in oxygen consumption (milliliters of oxygen per kilogram per minute) (before pregnancy, 3.02 +/- 0.43; in early pregnancy, 3.05 +/- 0.30; in late pregnancy, 3.31 +/- 0.37, p = 0.002) with advancing gestation.	Oxygen	479-485	leptin	Homo sapiens	135-141
25930178-0	2015	Evidence for enhanced oxygen surface exchange reaction in nanostructured Gd2O3-doped CeO2 films.	Oxygen	22-28	solute carrier family 25 member 16	Homo sapiens	73-89
9609576-4	1998	RESULTS: Using analysis of variance with repeated measures from pregravid to late pregnancy, a 66% increase (mean +/- SD) was found in leptin concentrations (in nanograms per milliliter) (before pregnancy, 25.4 +/- 19.9; in early pregnancy, 37.5 +/- 26.2; and in late pregnancy, 38.4 +/- 27.3, p = 0.003); a 9% increase in body fat (in kilograms) (before pregnancy, 29.4 +/- 15.7; in early pregnancy, 28.7 +/- 14.0; in late pregnancy, 31.4 +/- 14.6; p = 0.04); a 28% increase in oxygen consumption (in milliliters of oxygen per minute) (before pregnancy, 221.2 +/- 29.5; in early pregnancy, 230.4 +/- 42.9; in late pregnancy, 285.3 +/- 51.9; p &lt; 0.0001); and a 9% increase in oxygen consumption (milliliters of oxygen per kilogram per minute) (before pregnancy, 3.02 +/- 0.43; in early pregnancy, 3.05 +/- 0.30; in late pregnancy, 3.31 +/- 0.37, p = 0.002) with advancing gestation.	Oxygen	517-523	leptin	Homo sapiens	135-141
9609576-4	1998	RESULTS: Using analysis of variance with repeated measures from pregravid to late pregnancy, a 66% increase (mean +/- SD) was found in leptin concentrations (in nanograms per milliliter) (before pregnancy, 25.4 +/- 19.9; in early pregnancy, 37.5 +/- 26.2; and in late pregnancy, 38.4 +/- 27.3, p = 0.003); a 9% increase in body fat (in kilograms) (before pregnancy, 29.4 +/- 15.7; in early pregnancy, 28.7 +/- 14.0; in late pregnancy, 31.4 +/- 14.6; p = 0.04); a 28% increase in oxygen consumption (in milliliters of oxygen per minute) (before pregnancy, 221.2 +/- 29.5; in early pregnancy, 230.4 +/- 42.9; in late pregnancy, 285.3 +/- 51.9; p &lt; 0.0001); and a 9% increase in oxygen consumption (milliliters of oxygen per kilogram per minute) (before pregnancy, 3.02 +/- 0.43; in early pregnancy, 3.05 +/- 0.30; in late pregnancy, 3.31 +/- 0.37, p = 0.002) with advancing gestation.	Oxygen	517-523	leptin	Homo sapiens	135-141
9609576-4	1998	RESULTS: Using analysis of variance with repeated measures from pregravid to late pregnancy, a 66% increase (mean +/- SD) was found in leptin concentrations (in nanograms per milliliter) (before pregnancy, 25.4 +/- 19.9; in early pregnancy, 37.5 +/- 26.2; and in late pregnancy, 38.4 +/- 27.3, p = 0.003); a 9% increase in body fat (in kilograms) (before pregnancy, 29.4 +/- 15.7; in early pregnancy, 28.7 +/- 14.0; in late pregnancy, 31.4 +/- 14.6; p = 0.04); a 28% increase in oxygen consumption (in milliliters of oxygen per minute) (before pregnancy, 221.2 +/- 29.5; in early pregnancy, 230.4 +/- 42.9; in late pregnancy, 285.3 +/- 51.9; p &lt; 0.0001); and a 9% increase in oxygen consumption (milliliters of oxygen per kilogram per minute) (before pregnancy, 3.02 +/- 0.43; in early pregnancy, 3.05 +/- 0.30; in late pregnancy, 3.31 +/- 0.37, p = 0.002) with advancing gestation.	Oxygen	517-523	leptin	Homo sapiens	135-141
9609576-6	1998	When oxygen consumption was adjusted for maternal and fetal tissue mass, a significant negative correlation was found between leptin and oxygen consumption before pregnancy (r = -0.96, p &lt; 0.0001), in early pregnancy (r = -0.80, p = 0.0034), and in late pregnancy (r = -0.70, p = 0.02).	Oxygen	5-11	leptin	Homo sapiens	126-132
9609576-6	1998	When oxygen consumption was adjusted for maternal and fetal tissue mass, a significant negative correlation was found between leptin and oxygen consumption before pregnancy (r = -0.96, p &lt; 0.0001), in early pregnancy (r = -0.80, p = 0.0034), and in late pregnancy (r = -0.70, p = 0.02).	Oxygen	137-143	leptin	Homo sapiens	126-132
7546769-0	1995	Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages.	Oxygen	23-29	chemokine (C-C motif) ligand 3	Mus musculus	91-130
7546769-4	1995	We demonstrated that conditions of anoxia (95% nitrogen/5% CO2) or hyperoxia (95% oxygen/5% CO2) independently resulted in the increased expression of both TNF and MIP-1 alpha mRNA and protein from lipopolysaccharide (LPS)-stimulated AMO, as compared with cells cultured in room air.	Oxygen	82-88	chemokine (C-C motif) ligand 3	Mus musculus	164-175
7546769-5	1995	The specific culture condition of anoxia (x 6 h) followed by hyperoxia (x 18 h) produced the greatest increases in both TNF and MIP-1 alpha, suggesting that when following a period of anoxic priming, oxygen stress results in exaggerated cytokine production.	Oxygen	200-206	chemokine (C-C motif) ligand 3	Mus musculus	128-139
7546769-8	1995	These findings suggested that alterations in ambient oxygen tension can regulate the expression of TNF and MIP-1 alpha from activated AMO, and that oxidant-related cytokine production may represent an important mechanism by which inflammation occurs in the clinical settings of ischemia-reperfusion injury and hyperoxia.	Oxygen	53-59	chemokine (C-C motif) ligand 3	Mus musculus	107-118
8648056-2	1995	The Dead Sea region of Israel is the lowest point on earth (402 m below sea level), and therefore the oxygen pressure is increased.	Oxygen	102-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
8648056-2	1995	The Dead Sea region of Israel is the lowest point on earth (402 m below sea level), and therefore the oxygen pressure is increased.	Oxygen	102-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	72-75
9558407-1	1998	Hypoxic induction of erythropoietin (Epo) and other oxygen-dependent genes is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transactivator consisting of an alpha and a beta subunit.	Oxygen	52-58	erythropoietin	Mus musculus	21-35
9558407-1	1998	Hypoxic induction of erythropoietin (Epo) and other oxygen-dependent genes is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transactivator consisting of an alpha and a beta subunit.	Oxygen	52-58	erythropoietin	Mus musculus	37-40
9558407-7	1998	Prolonged exposure of mice to hypoxia (7.5% O2 for up to 72 hours) also caused a decrease in liver HIF-1alpha mRNA, whereas aldolase mRNA levels increased.	Oxygen	44-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	99-109
8554871-9	1995	Intercostal recession (relative risk RR 2.55; 95% CI 1.28, 5.08) and sternal retraction (RR 1.60; 95% CI 1.06, 2.42) predicted the need for supplemental oxygen with moderate accuracy.	Oxygen	153-159	ribonucleotide reductase regulatory subunit M2	Homo sapiens	37-41
9604300-11	1998	With liver slices produced by both tissue slicers 50 microM sodium arsenite produced a greater induction of heat shock protein 70 levels in slices cultured for 24 h in a high oxygen than in an air atmosphere.	Oxygen	175-181	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	108-129
25930178-1	2015	The effect of microstructure of Gd2O3-doped CeO2 (GDC) films on oxygen surface exchange and diffusion is reported.	Oxygen	64-70	solute carrier family 25 member 16	Homo sapiens	32-48
25930178-1	2015	The effect of microstructure of Gd2O3-doped CeO2 (GDC) films on oxygen surface exchange and diffusion is reported.	Oxygen	64-70	solute carrier family 25 member 16	Homo sapiens	50-53
25930178-4	2015	(18)O isotope exchange depth profiling with dynamic secondary ion mass spectroscopy is employed to evaluate the oxygen surface exchange coefficient k* and the diffusion coefficient D* at T = 600  C. The as-grown GDC exhibits up to 10 times higher k* than the annealed film.	Oxygen	112-118	solute carrier family 25 member 16	Homo sapiens	212-215
9494102-2	1998	Metmyoglobin catalysed the decomposition of HPODE, resulting in peroxide, oxygen and conjugated diene depletion, together with the transient production of ferryl myoglobin.	Oxygen	74-80	myoglobin	Homo sapiens	3-12
7489357-3	1995	We show that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut-off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells.	Oxygen	80-86	vascular endothelial growth factor A	Rattus norvegicus	117-151
7489357-3	1995	We show that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut-off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells.	Oxygen	80-86	vascular endothelial growth factor A	Rattus norvegicus	153-157
25941362-0	2015	Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.	Oxygen	34-40	G elongation factor mitochondrial 1	Homo sapiens	52-56
25941362-4	2015	Based on the close proximity of the phosphate oxygen of A2662 of the SRL to the supposedly catalytic histidine of EF-G (His87), we probed this interaction by an atomic mutagenesis approach.	Oxygen	46-52	G elongation factor mitochondrial 1	Homo sapiens	114-118
25581126-3	2015	In this study, three long aspect ratio (LAR) materials (MWCNTs, single-walled carbon nanotubes, and silver nanowires) are used to compare with spherical carbon black and silver nanoparticles for their ability to trigger oxygen burst activity and NLRP3 assembly.	Oxygen	220-226	NLR family, pyrin domain containing 3	Mus musculus	246-251
7673128-2	1995	The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism.	Oxygen	4-10	erythropoietin	Mus musculus	69-83
7673128-2	1995	The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism.	Oxygen	4-10	erythropoietin	Mus musculus	85-88
9688212-3	1998	During the first reaction phase a stoichiometric amount of oxygen is consumed (1 mole oxygen per 4 moles thiol) with minimal .OH production.	Oxygen	59-65	PER3 pseudogene 1	Homo sapiens	93-98
9688212-3	1998	During the first reaction phase a stoichiometric amount of oxygen is consumed (1 mole oxygen per 4 moles thiol) with minimal .OH production.	Oxygen	86-92	PER3 pseudogene 1	Homo sapiens	93-98
9486970-4	1998	We evaluated survival, indices of oxidative injury, and lung and HO expression in HO-2 null mutant mice exposed to &gt; 95% O2 compared with wild-type controls.	Oxygen	124-126	heme oxygenase 2	Mus musculus	82-86
24985791-7	2015	IL-6 and MIP-1beta levels in NPA were directly correlated to oxygen therapy.	Oxygen	61-67	C-C motif chemokine ligand 4	Homo sapiens	9-18
9486970-8	1998	These results demonstrate that the absence of HO-2 is associated with induction of HO-1 and increased oxygen toxicity in vivo, apparently due to accumulation of lung iron.	Oxygen	102-108	heme oxygenase 2	Mus musculus	46-50
9500516-10	1998	C2D macrophages also secreted significantly more IL-10 and less NO and O2- after lipopolysaccharide or phorbol ester stimulation in vitro than wild-type macrophages.	Oxygen	71-73	secretoglobin, family 2B, member 26	Mus musculus	0-3
8531634-6	1995	The calculation of VO2 using the K2 system which assumes that RER = 1.00 had specific effects for the calculation of oxygen uptake.	Oxygen	117-123	retention in endoplasmic reticulum sorting receptor 1	Homo sapiens	62-69
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	93-95	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	28-32
7539918-5	1995	HIF-1 alpha and HIF-1 beta (ARNT) RNA and protein levels were induced in cells exposed to 1% O2 and decayed rapidly upon return of the cells to 20% O2, consistent with the role of HIF-1 as a mediator of transcriptional responses to hypoxia.	Oxygen	148-150	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	28-32
24985791-8	2015	PB showed an increase in IL-8 and a decrease in MIP-1alpha and MIP-1beta in the RSV-AB group (only MIP-1beta associated to the need for oxygen therapy).	Oxygen	136-142	C-C motif chemokine ligand 4	Homo sapiens	99-108
25752672-7	2015	Vascular endothelial growth factor-A blocker 1 was found most effective in increasing cellular viability and maintaining normal VEGF levels under hypoxia (0.5% oxygen) in N2a cells.	Oxygen	160-166	vascular endothelial growth factor A	Rattus norvegicus	0-34
9383439-4	1995	Mutation of the heme axial ligand (Met80) to Ala in Saccharomyces cerevisiae iso-1-cytochrome c yields a protein (Ala80cyt c) capable of binding exogenous ligands such as dioxygen and cyanide.	Oxygen	171-179	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	77-82
7651752-5	1995	We report here that maternal hypoxia (11-13% O2) leads to 2-3-fold increases (p &lt; 0.01) in fetal adrenal TH, DBH, and NPY mRNA levels on the day before birth.	Oxygen	45-47	dopamine beta-hydroxylase	Rattus norvegicus	112-115
7651752-7	1995	Only ENK mRNA levels increased (5-fold; p &lt; 0.01) when pups were born in 11-13% O2; however, still less (p &lt; 0.01) than after birth in room air when it increased nine times (p &lt; 0.01).	Oxygen	83-85	proenkephalin	Rattus norvegicus	5-8
9521050-4	1998	We show that cross-linking of P-selectin glycoprotein ligand-1 (PSGL-1) on mouse neutrophils with an antibody-like recombinant form of P-selectin or with monoclonal antibodies stimulated the production of reactive oxygen intermediates and enhanced neutrophil attachment to intercellular adhesion molecule 1 (ICAM-1)-expressing CHO cells.	Oxygen	214-220	selectin, platelet (p-selectin) ligand	Mus musculus	30-62
9468294-0	1998	Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures.	Oxygen	111-117	glucagon receptor	Rattus norvegicus	27-44
9577415-4	1998	Osteocalcin concentration was higher in bone cells than in pericytes, was not detected in fibroblasts, and in bone cells and pericytes the concentration was highest in 21% oxygen.	Oxygen	172-178	bone gamma-carboxyglutamate protein	Bos taurus	0-11
26314099-9	2015	The distributions of dissolved oxygen and inorganic carbon concentration with the change of the depth of the sea might be an important reason leading to the difference of NPMC structure and even the difference of PCFC at different depth of the sea.	Oxygen	31-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
9840812-9	1998	Transient transfection experiments demonstrate that the HIF3alpha-ARNT interaction can occur in vivo, and that the activity of HIF3alpha is upregulated in response to cobalt chloride or low oxygen tension.	Oxygen	190-196	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	66-70
7728992-4	1995	In the present study, VPF/VEGF mRNA and protein were demonstrated to be markedly stimulated in primary rat cardiac myocytes in vitro in response to reduction of the oxygen tension to 1% or inhibition of the electron transport chain.	Oxygen	165-171	vascular endothelial growth factor A	Rattus norvegicus	22-25
7728992-4	1995	In the present study, VPF/VEGF mRNA and protein were demonstrated to be markedly stimulated in primary rat cardiac myocytes in vitro in response to reduction of the oxygen tension to 1% or inhibition of the electron transport chain.	Oxygen	165-171	vascular endothelial growth factor A	Rattus norvegicus	26-30
26314099-9	2015	The distributions of dissolved oxygen and inorganic carbon concentration with the change of the depth of the sea might be an important reason leading to the difference of NPMC structure and even the difference of PCFC at different depth of the sea.	Oxygen	31-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	244-247
7731983-0	1995	The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity.	Oxygen	120-126	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	4-8
7731983-3	1995	This gene, named ATX1, was originally isolated by its ability to suppress oxygen toxicity in yeast lacking SOD.	Oxygen	74-80	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	17-21
9564607-2	1998	In part, this oxidative stress is the result of the oxidation of dopamine by the action of monoamine oxidases (MAO) A and B to generate hydrogen peroxide and subsequent oxygen free radicals.	Oxygen	169-175	monoamine oxidase A	Homo sapiens	91-123
25303683-4	2015	At 20% O2, DMF induced a stronger antioxidant response compared to 5% O2 as evidenced by a higher expression of heme oxygenase-1, NAD(P)H:quinone oxydoreductase-1 and superoxide dismutase-2.	Oxygen	70-72	heme oxygenase 1	Homo sapiens	112-189
9473107-5	1998	(3) Does supplemental oxygen modify PVR response to PLV?	Oxygen	22-28	PVR cell adhesion molecule	Homo sapiens	36-39
9473107-25	1998	PVR recovered to 189+/-19 after 60 minutes of oxygen recovery (P = ns v baseline).	Oxygen	46-52	PVR cell adhesion molecule	Homo sapiens	0-3
9473107-27	1998	Although PLV alone decreases PVR in the injured lung without supplemental oxygen, elevated PVR associated with hypoxia was ameliorated only by supplemental oxygen in the liquid ventilated lung.	Oxygen	156-162	PVR cell adhesion molecule	Homo sapiens	91-94
7731983-6	1995	In yeast cells, ATX1 evidently acts in the transport and/or partitioning of copper, and this role in copper homeostasis appears to be directly relevant to the ATX1 suppression of oxygen toxicity: ATX1 was incapable of compensating for SOD when cells were depleted of exogenous copper.	Oxygen	179-185	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	16-20
7731983-6	1995	In yeast cells, ATX1 evidently acts in the transport and/or partitioning of copper, and this role in copper homeostasis appears to be directly relevant to the ATX1 suppression of oxygen toxicity: ATX1 was incapable of compensating for SOD when cells were depleted of exogenous copper.	Oxygen	179-185	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	159-163
7731983-6	1995	In yeast cells, ATX1 evidently acts in the transport and/or partitioning of copper, and this role in copper homeostasis appears to be directly relevant to the ATX1 suppression of oxygen toxicity: ATX1 was incapable of compensating for SOD when cells were depleted of exogenous copper.	Oxygen	179-185	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	159-163
25686096-1	2015	Oxygen (O2) is required for cytochrome P450 (CYP)-dependent drug metabolism.	Oxygen	0-6	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-43
7710944-6	1995	Evidence that oxygen activation contributed to cytotoxicity was that glutathione oxidation occurred well before cytotoxicity ensued and that tirapazamine was more cytotoxic towards catalase- or glutathione reductase-inactivated hepatocytes.	Oxygen	14-20	glutathione-disulfide reductase	Rattus norvegicus	194-215
9780756-4	1998	The mechanisms of this effect of LPL is 1) augmentation of the adhesion and aggregation of LDL; 2) influence on the oxygen modification of LDL and increased uptake of oxy-LDL by macrophages; 3) dysfunction of endothelial barrier and retention of atherogenic lipoproteins in the arterial wall and 4) the activity of LPL macrophage origin.	Oxygen	116-122	lipoprotein lipase	Homo sapiens	33-36
25686096-1	2015	Oxygen (O2) is required for cytochrome P450 (CYP)-dependent drug metabolism.	Oxygen	0-6	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-48
25686096-1	2015	Oxygen (O2) is required for cytochrome P450 (CYP)-dependent drug metabolism.	Oxygen	8-10	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-43
25686096-1	2015	Oxygen (O2) is required for cytochrome P450 (CYP)-dependent drug metabolism.	Oxygen	8-10	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-48
9446746-1	1997	The characteristics of attractor control of the changes in the molecular vibrations of a protein have previously been detected when an enzyme (chymotrypsin) reacted with a specific substrate and when myoglobin interacted with oxygen.	Oxygen	226-232	myoglobin	Homo sapiens	200-209
27206094-1	2015	OBJECTIVE: To assess whether hyperbaric oxygen sessions elevate serum levels of anti-Mullerian hormone (AMH) in patients diagnosed with infertility with serum levels of less than or equal to 1 ng/dl AMH.	Oxygen	40-46	anti-Mullerian hormone	Homo sapiens	104-107
9704061-5	1997	To this end, we studied the effects of pentoxifylline on TNF- and G-CSF-induced modulation of neutrophil chemotaxis and O2 release.	Oxygen	120-122	colony stimulating factor 3	Homo sapiens	66-71
9416972-10	1997	In conclusion, SR-4554 undergoes an oxygen-dependent metabolism that involves NADPH:cytochrome P450 reductase.	Oxygen	36-42	cytochrome p450 oxidoreductase	Mus musculus	78-109
9430337-8	1997	Therefore, for the attachment of both cultured epithelial cells and fibroblasts to oxygen-containing surfaces in the presence of serum, there is a high requirement for serum vitronectin but a lesser requirement for fibronectin.	Oxygen	83-89	fibronectin 1	Bos taurus	215-226
7607137-6	1995	We conclude that induction of a functional CYP1A1 monooxygenase by TCDD stimulates a pathway that generates thiol-sensitive reactive oxygen intermediates which, in turn, are responsible for the TCDD-dependent activation of genes linked to the LTR.	Oxygen	54-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
7740081-0	1995	Induction of cyclobutane pyrimidine dimer photolyase in cultured fish cells by fluorescent light and oxygen stress.	Oxygen	101-107	CPD photolyase	Oryzias latipes	42-52
7740081-5	1995	These results suggest the involvement of oxygen stress in the induction of photolyase by fluorescent light.	Oxygen	41-47	CPD photolyase	Oryzias latipes	75-85
7876079-11	1995	The inactivation of the disulfide reducing activity of thioredoxin reductase and thioredoxin with a concomitant large increase of the NADPH oxidase activity producing reactive oxygen intermediates may mediate effects of DNCB on cells in vivo.	Oxygen	176-182	thioredoxin	Homo sapiens	55-66
27206094-8	2015	CONCLUSIONS: This study showed that hyperbaric oxygen sessions can increase serum AMH levels, with a significant increase of 116% in one case.	Oxygen	47-53	anti-Mullerian hormone	Homo sapiens	82-85
7876079-11	1995	The inactivation of the disulfide reducing activity of thioredoxin reductase and thioredoxin with a concomitant large increase of the NADPH oxidase activity producing reactive oxygen intermediates may mediate effects of DNCB on cells in vivo.	Oxygen	176-182	thioredoxin	Homo sapiens	81-92
9414640-1	1997	GM-CSF may induce pulmonary complications, such as dyspnea with temporary decreases in oxygen saturation described as first dose effect for higher dosages of intravenous rhGM-CSF.	Oxygen	87-93	colony stimulating factor 2	Homo sapiens	0-6
25713078-9	2015	We found that oxygen consumption and fatty acid oxidation were increased markedly in Sln(OE) mice.	Oxygen	14-20	sarcolipin	Mus musculus	85-88
9382954-0	1997	A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension.	Oxygen	81-87	erythropoietin	Mus musculus	49-63
7821403-4	1995	Injection of interleukin-1 into schistosome-susceptible (M-line) and resistant (13-16-R1) strains of B. glabrata increased hemocyte phagocytosis of target particles and phagocytosis stimulated O2- production in both snail strains at 24 hr postexposure to the parasite.	Oxygen	193-195	interleukin 1 alpha	Homo sapiens	13-26
25713078-9	2015	We found that oxygen consumption and fatty acid oxidation were increased markedly in Sln(OE) mice.	Oxygen	14-20	sarcolipin	Mus musculus	89-91
9336970-4	1997	Ce(IV) ions chelate with oxygens of the hydroxyl groups at the 1,4 position and the carbonyl function on C-9 and C-10, then intercalate into the base pairs of DNA together.	Oxygen	25-32	complement component 9	Mus musculus	105-108
25684657-7	2015	However, leptin protein concentration (cell supernatants) peaked at 8% oxygen (normoxia) and was significantly reduced at 0.1% oxygen.	Oxygen	71-77	leptin	Homo sapiens	9-15
7744303-0	1995	Lung damage in paraquat poisoning and hyperbaric oxygen exposure: superoxide-mediated inhibition of phospholipase A2.	Oxygen	49-55	phospholipase A2 group IB	Rattus norvegicus	100-116
7744303-15	1995	Inactivation of phospholipase A2, detected in paraquat or oxygen exposed rats, could be attributed to a O2(.-)-driven Fenton reaction.	Oxygen	58-64	phospholipase A2 group IB	Rattus norvegicus	16-32
7744303-15	1995	Inactivation of phospholipase A2, detected in paraquat or oxygen exposed rats, could be attributed to a O2(.-)-driven Fenton reaction.	Oxygen	104-106	phospholipase A2 group IB	Rattus norvegicus	16-32
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	interleukin 3	Homo sapiens	228-246
25684657-7	2015	However, leptin protein concentration (cell supernatants) peaked at 8% oxygen (normoxia) and was significantly reduced at 0.1% oxygen.	Oxygen	127-133	leptin	Homo sapiens	9-15
25637678-4	2015	Based on chemical shift isotropy and anisotropy analyses, we postulated that Ca(+2) might have associated with the oxygen attached to C17 via a lone-pair of electrons, which induced a conformational change in DHEA.	Oxygen	115-121	cytokine like 1	Homo sapiens	134-137
9311966-7	1997	Leptin increased oxygen consumption in conditions in which diet-induced thermogenesis was low, i.e., in fed ob/ob mice and in food-deprived lean mice, but not in fed adrenalectomized ob/ob mice or in fed lean mice.	Oxygen	17-23	leptin	Mus musculus	0-6
9316487-5	1997	In isolated type II cells from 60 and 85% O2-exposed animals, gamma-GT activity decreased by -70 and -88%, respectively, which was supported by cytochemical staining.	Oxygen	42-44	gamma-glutamyltransferase 1	Rattus norvegicus	62-70
9316487-6	1997	Type II cell gamma-GT mRNA expression tended only to decrease after 85% O2.	Oxygen	72-74	gamma-glutamyltransferase 1	Rattus norvegicus	13-21
7851416-4	1995	Induction of HSP27 kinase activity by TNF or H2O2 was completely inhibited by first treating the cells with the antioxidant N-acetyl-L-cysteine, suggesting that generation of reactive oxygen metabolites was the key triggering element of this induction.	Oxygen	184-190	heat shock protein family B (small) member 1	Homo sapiens	13-18
7840232-5	1995	As an increase in immunoreactive type I collagen was evident by day 6 of O2 exposure, the gene expressions of interstitial collagenase (MMP-1), stromelysin, and the tissue inhibitor of the metalloproteinases (TIMP) were also examined.	Oxygen	73-75	matrix metallopeptidase 1	Rattus norvegicus	110-134
25641750-10	2015	In conclusion, etamicastat and nepicastat behave as multisubstrate DBH inhibitors, binding reversibly and preferentially to the reduced form of the enzyme, and simultaneously at the substrate and oxygen binding sites.	Oxygen	196-202	dopamine beta-hydroxylase	Homo sapiens	67-70
7840232-6	1995	Increased mRNA expressions of interstitial collagenase and TIMP preceded those of type I collagen and TGF-beta 1, occurring at 4-6 days of exposure to 85% O2, while there was no significant change in stromelysin mRNA.	Oxygen	155-157	matrix metallopeptidase 1	Rattus norvegicus	30-54
7556117-0	1995	Acute mountain sickness relates to sea-level partial pressure of oxygen.	Oxygen	65-71	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
9316487-8	1997	When in culture, type II cell gamma-GT activity and GSH levels remained, respectively, 2.5- and 1.9-fold lower in the 60% O2-exposed group, but, in the 85% O2-exposed group, gamma-GT activity increased 2.1-fold, and GSH levels dropped to the levels of the control cells.	Oxygen	122-124	gamma-glutamyltransferase 1	Rattus norvegicus	30-38
9363465-7	1997	We showed that aCL bound to beta 2-GPI interacting with poly-oxygenated plates and in the absence of CL, an interaction which depends on introduction of oxygen atoms on the polystyrene surface.	Oxygen	61-67	apolipoprotein H	Homo sapiens	28-38
25377876-6	2015	PHD2 genetic ablation and pharmacological inhibition attenuated protein levels of the key lipolytic effectors hormone-sensitive lipase and adipose triglyceride lipase (ATGL), suggesting a link between adipocyte oxygen sensing and fatty acid release.	Oxygen	211-217	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
9313864-7	1997	An examination of the SAR of these analogues shows that translocating the napthyl group in AAIs from the C-3 position to C-4 via an oxygen (ether linkage) decreases activity which is in contrast to previous findings that a naphthylcarbonyl at C-4 retains activity.	Oxygen	132-138	complement C4A (Rodgers blood group)	Homo sapiens	121-124
9313864-7	1997	An examination of the SAR of these analogues shows that translocating the napthyl group in AAIs from the C-3 position to C-4 via an oxygen (ether linkage) decreases activity which is in contrast to previous findings that a naphthylcarbonyl at C-4 retains activity.	Oxygen	132-138	complement C4A (Rodgers blood group)	Homo sapiens	243-246
9262426-2	1997	In this study, we demonstrate that the exposure of rats to 4 atmospheres of 100% oxygen for 90 min is associated with increased levels of lipid peroxidation products [malonaldehyde (MDA) and 4-hydroxyalkenals (4-HDA)] and with changes in the activities of two antioxidative enzymes [glutathione peroxidase (GPX) and glutathione reductase (GR)], as well as in the glutathione status in the lungs and in the brain.	Oxygen	81-87	glutathione-disulfide reductase	Rattus norvegicus	316-337
9262426-2	1997	In this study, we demonstrate that the exposure of rats to 4 atmospheres of 100% oxygen for 90 min is associated with increased levels of lipid peroxidation products [malonaldehyde (MDA) and 4-hydroxyalkenals (4-HDA)] and with changes in the activities of two antioxidative enzymes [glutathione peroxidase (GPX) and glutathione reductase (GR)], as well as in the glutathione status in the lungs and in the brain.	Oxygen	81-87	glutathione-disulfide reductase	Rattus norvegicus	339-341
7758538-1	1995	The enzyme catalase protects aerobic organisms from oxygen free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Oxygen	52-58	Catalase	Drosophila melanogaster	11-19
7758538-1	1995	The enzyme catalase protects aerobic organisms from oxygen free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Oxygen	124-130	Catalase	Drosophila melanogaster	11-19
22059975-3	1995	Up to 5 days post mortem, increases in oxygen partial pressure with lengthening storage periods also led to higher percentages of oxymyoglobin, following exposure to air 1 min to 5 h. Further storage for up to 13 days decreased oxygenation, despite higher oxygen partial pressures.	Oxygen	39-45	zinc finger CCHC-type containing 7	Homo sapiens	166-171
7644357-2	1995	Unlike tissue plasminogen activator and plasminogen activator inhibitor, plasma levels of thrombomodulin were closely related to both transcutaneous oxygen pressure (p = 0.01) and the graded clinical stages of disease (p = 0.02).	Oxygen	149-155	thrombomodulin	Homo sapiens	90-104
9387095-4	1997	These and other observations suggest that the normal cell responds physiologically to changes in oxygen tension or the availability of glucose by altering glycolysis through the ChoRE, which hypothetically binds c-Myc, HIF-1, or related factors.	Oxygen	97-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	212-217
25377876-6	2015	PHD2 genetic ablation and pharmacological inhibition attenuated protein levels of the key lipolytic effectors hormone-sensitive lipase and adipose triglyceride lipase (ATGL), suggesting a link between adipocyte oxygen sensing and fatty acid release.	Oxygen	211-217	patatin-like phospholipase domain containing 2	Mus musculus	139-166
7734844-3	1994	This conformation is stabilized by the formation of a hydrogen bond between the carbonyl oxygen of GlcNAc2 with the O3/O4 hydroxyls of the alpha 1,6-linked mannose residue.	Oxygen	89-95	adrenoceptor alpha 1D	Homo sapiens	139-148
25422368-1	2015	In mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands.	Oxygen	98-104	erythropoietin	Rattus norvegicus	30-44
7706407-2	1994	We report here that Cx26-positive gap junctions rapidly appear in the centrilobular hepatocytes of adult female rat livers during a 30 minute perfusion of the liver through the hepatic portal vein with a 1:1 mixture of Dulbecco"s modified Eagle"s medium (DMEM) and oxygen transport FC-43 fluid at a physiological flow rate without any changes in the distribution of Cx32.	Oxygen	265-271	gap junction protein, beta 2	Rattus norvegicus	20-24
9288847-7	1997	The rates of synthesis of oxygen-regulated proteins (GRP78, GRP94, HSP70 and HSP90) were transiently perturbed to a similar extent in all lines after hypoxia treatment.	Oxygen	26-32	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
9211891-3	1997	Ala replacements for Asp63 or Gln49 resulted in reduced TF affinity concordant with the number of eliminated Ca2+-coordinating oxygen atoms in the respective side chains.	Oxygen	127-133	coagulation factor III, tissue factor	Homo sapiens	56-58
25422368-7	2015	Suppression of hepatic erythropoietin expression by nitrate may thus act to decrease blood viscosity while matching oxygen supply to demand, whereas renal oxygen sensing could act as a brake, averting a potentially detrimental fall in hematocrit.	Oxygen	116-122	erythropoietin	Rattus norvegicus	23-37
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-46
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	48-52
7944074-9	1994	RESULTS: Arterial oxygenation increased from a median partial pressure of arterial oxygen of 51.6 mm Hg in Jerusalem to 67.0 mm Hg at the Dead Sea, an increase of 15.2 mm Hg (95% CI of paired difference, 4.1 to 20.4 mm Hg; P = 0.001).	Oxygen	18-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	143-146
25720664-0	2015	Oxygen dissociation curves in altitude and sea-level residents.	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
7980544-5	1994	It is concluded that an oxygen sensing mechanism is present in cardiac cells and controls the expression of VEGF mRNAs.	Oxygen	24-30	vascular endothelial growth factor A	Rattus norvegicus	108-112
9247149-3	1997	Release was also accelerated by ceruloplasmin; most importantly, the effect of this protein was greatest when iron release was occurring rapidly, stimulated by apotransferrin, or under conditions of limited oxygen.	Oxygen	207-213	ceruloplasmin	Homo sapiens	32-45
9247149-4	1997	Thus iron release involves both apotransferrin and ferrotransferrin, with ceruloplasmin playing a role in tissues with limited oxygen supply, as in the liver in vivo.	Oxygen	127-133	ceruloplasmin	Homo sapiens	74-87
25514442-5	2015	Increased nitration of both IGF-I and IGF-R1 was evident in 60% O2-exposed lungs, which was reversible by concurrent treatment with a peroxynitrite decomposition catalyst.	Oxygen	64-66	insulin-like growth factor 1	Rattus norvegicus	28-33
9199416-7	1997	Coinfection of M. smegmatis expressing the gene encoding TR-Trx together with Staphylococcus aureus, which is known to be killed via oxygen-dependent microbicidal mechanisms, revealed that the TR-Trx gene product interferes with the intracellular killing of this bacterium.	Oxygen	133-139	thioredoxin	Homo sapiens	60-63
9199416-7	1997	Coinfection of M. smegmatis expressing the gene encoding TR-Trx together with Staphylococcus aureus, which is known to be killed via oxygen-dependent microbicidal mechanisms, revealed that the TR-Trx gene product interferes with the intracellular killing of this bacterium.	Oxygen	133-139	thioredoxin	Homo sapiens	196-199
9199416-9	1997	The data obtained in this study suggest that the Trx system of M. leprae can inhibit oxygen-dependent killing of intracellular bacteria and thus may represent one of the mechanisms by which M. leprae can deal with oxidative stress within human mononuclear phagocytes.	Oxygen	85-91	thioredoxin	Homo sapiens	49-52
9268919-4	1997	These results indicate that even though catalase is present at a high concentration in the medium, it cannot prevent cytotoxicity by a high concentration of ascorbate because the oxygen radical derived from ascorbate inhibits its activity.	Oxygen	179-185	catalase	Cavia porcellus	40-48
7945347-2	1994	Both enzymes show dual peroxidase and oxygenase activity, being the latter the oxidation of porphobilinogen in the presence of oxygen and a reducing agent.	Oxygen	38-44	peroxidase-like	Triticum aestivum	23-33
7634074-0	1994	Photolysis-induced structural changes in single crystals of carbonmonoxy myoglobin at 40 K. Myoglobin"s reversible binding of oxygen is a model for studies of protein control of ligand binding and discrimination.	Oxygen	126-132	myoglobin	Homo sapiens	73-82
7634074-0	1994	Photolysis-induced structural changes in single crystals of carbonmonoxy myoglobin at 40 K. Myoglobin"s reversible binding of oxygen is a model for studies of protein control of ligand binding and discrimination.	Oxygen	126-132	myoglobin	Homo sapiens	92-101
25514442-13	2015	We conclude that peroxynitrite contributes to the impaired alveologenesis observed following the exposure of neonatal rats to 60% O2 both by preventing binding of IGF-I to the IGF-R1, secondary to nitration of the IGF-R1, and by causing an up-regulation of the growth inhibitor, TGFbeta1.	Oxygen	130-132	insulin-like growth factor 1	Rattus norvegicus	163-168
9160836-8	1997	In addition, alveolar macrophages express IGF-I and type II epithelial cells express IGF-II in control and oxygen-injured lung.	Oxygen	107-113	insulin-like growth factor 1	Rattus norvegicus	42-47
25648629-6	2015	Furthermore, metals can exert cellular toxicity due to their red-ox potential, which leads to the formation of reactive oxygen species, exacerbating the noxious effects of alphaSyn.	Oxygen	120-126	synuclein alpha	Homo sapiens	172-180
9167844-0	1997	Enhancement of brain p0(2) during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution.	Oxygen	78-84	tumor protein, translationally-controlled 1	Homo sapiens	21-26
9167844-6	1997	This report describes an oxygen carrying hyperosmolar solution which enhances brain p0(2) and diminishes interstitial fluid accumulation.	Oxygen	25-31	tumor protein, translationally-controlled 1	Homo sapiens	84-89
8052661-5	1994	AGE-recombinant tau generated reactive oxygen intermediates and, when introduced into the cytoplasm of SH-SY5Y neuroblastoma cells, induced oxidant stress.	Oxygen	39-45	microtubule associated protein tau	Homo sapiens	16-19
7917724-1	1994	We assessed the inspiratory to end-tidal oxygen difference (PIO2-PE"O2) during voluntary hyperventilation in 10 healthy male volunteers.	Oxygen	41-47	solute carrier family 25 member 4	Homo sapiens	65-70
25476521-2	2015	However, plastic substrates such as PEN and PET are permeable to water, oxygen and volatile electrolyte solvents, which is detrimental to the cell stability.	Oxygen	72-78	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	36-39
7824095-8	1994	Two of the seleno-dependent enzymes Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX) are speculated to play a key-role in the defence of neuronal cells against oxygen radical formation and peroxidative processes.	Oxygen	202-208	glutathione peroxidase 4	Homo sapiens	69-118
7824095-8	1994	Two of the seleno-dependent enzymes Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX) are speculated to play a key-role in the defence of neuronal cells against oxygen radical formation and peroxidative processes.	Oxygen	202-208	glutathione peroxidase 4	Homo sapiens	120-125
12223663-9	1997	Photosynthetic oxygen evolution rates and in vivo Chl fluorescence showed that GSA-AT antisense plants are photochemically competent.	Oxygen	15-21	glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic	Nicotiana tabacum	79-85
9126290-6	1997	Flt-1, Flk-1, and ACE-containing cells were detected in 3% O2-treated explants, whereas 20% O2 explants were virtually negative.	Oxygen	59-61	kinase insert domain receptor	Rattus norvegicus	7-12
25333920-2	2015	Here, we studied the mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	40-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	147-178
9020146-9	1997	These data indicate that the transcription factor NF-IL-6 is sensitive to environmental oxygen deprivation, and the tissue-specific pattern of gene expression suggests that local mechanisms have an important regulatory effect.	Oxygen	88-94	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	50-57
9976610-0	1994	Sizable oxygen isotope effects in the electron-doped Pr1.85Ce0.15CuO4-y.	Oxygen	8-14	transmembrane protein 37	Homo sapiens	53-56
9027730-0	1997	Oxygen-dependent regulation of erythropoietin gene expression in rat hepatocytes.	Oxygen	0-6	erythropoietin	Rattus norvegicus	31-45
25333920-2	2015	Here, we studied the mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha).	Oxygen	40-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	180-190
9027730-2	1997	Synthesis of Epo is induced in response to low oxygen (hypoxia).	Oxygen	47-53	erythropoietin	Rattus norvegicus	13-16
17586922-1	1994	In high altitude areas, inspired atmosphere oxygen decrease proportionally to the vertical distance from sea level.	Oxygen	44-50	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
9027733-12	1997	We also found that the genes that encode the c-Fos and JunB transcription factor proteins are regulated by reduced O2 tension.	Oxygen	115-117	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-59
25578484-1	2015	Myoglobin (Mb) and hemoglobin have the biological ability to carry/store oxygen (O2), a property which requires its heme iron atom to be in the ferrous--Fe(II)--state.	Oxygen	73-79	myoglobin	Homo sapiens	0-9
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Oxygen	23-29	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-72
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Oxygen	23-29	aryl hydrocarbon receptor nuclear translocator	Mus musculus	145-149
9027741-1	1997	The discovery that the oxygen-regulated transcription factor HIF-1 alpha and the dioxin receptor AhR share the common heterodimerization partner ARNT (HIF-1 beta) raised the question whether a cross-talk between oxygen and dioxin signal transduction pathways exists.	Oxygen	23-29	aryl hydrocarbon receptor nuclear translocator	Mus musculus	151-161
9042602-7	1997	In both cases preexposure of cells to ANP (10(-8)-10(-6) M) for 2 h enhances reactive oxygen production.	Oxygen	86-92	natriuretic peptide type A	Mus musculus	38-41
9269424-1	1997	Facilitation of oxygen transport by myoglobin has been assessed by many researchers.	Oxygen	16-22	myoglobin	Homo sapiens	36-45
9269424-4	1997	In this study, oxygen transport by myoglobin facilitation is added to a proven cardiac tissue model which contains axial diffusion in the tissue and capillary regions, the Radially-Averaged, Axially-Distributed (RAAD) model.	Oxygen	15-21	myoglobin	Homo sapiens	35-44
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	21-27	epidermal growth factor	Homo sapiens	72-75
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	83-89	epidermal growth factor	Homo sapiens	72-75
8020609-2	1994	Compared to standard oxygen, the binding of both 125I-TGF-beta and 125I-EGF in low oxygen tension was diminished by a mean of 65 and 62%, respectively (P &lt; 0.02), and was reversed by reexposure of cultures to standard oxygen tension.	Oxygen	83-89	epidermal growth factor	Homo sapiens	72-75
8193143-7	1994	The third residue of the catalytic triad Asp197 is located on the opposite side of the inhibitor binding cleft with one of its carbonyl oxygens at a 3.3-A distance from the anomeric carbon C-1 of the inhibitor center.	Oxygen	136-143	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	189-192
9269424-6	1997	The objective is to determine if this coupling effect increases the facilitation of oxygen transport by myoglobin.	Oxygen	84-90	myoglobin	Homo sapiens	104-113
9269424-17	1997	The steady state solution of the RAAD model with myoglobin suggests that, in the presence of axial diffusion, facilitation of oxygen diffusion to tissue is not myoglobin"s primary function.	Oxygen	126-132	myoglobin	Homo sapiens	49-58
25578484-1	2015	Myoglobin (Mb) and hemoglobin have the biological ability to carry/store oxygen (O2), a property which requires its heme iron atom to be in the ferrous--Fe(II)--state.	Oxygen	81-83	myoglobin	Homo sapiens	0-9
25478925-5	2015	The partial hypoxia revealed opposing effects, with a significant increase in steroidogenic response at 10% O2 in dbcAMP-treated cells: Star-promoter activity, mRNA and protein expression were increased.	Oxygen	108-110	steroidogenic acute regulatory protein	Mus musculus	136-140
8895810-1	1997	The diversity of application of the thiol drug NAC in both the experimental setting, as a tool for the study of the mechanisms and consequences of oxidative stress, and the clinical setting, as a therapeutic agent, clearly reflects the central role played by the redox chemistries of the group XVI elements, oxygen and sulfur, in biology.	Oxygen	308-314	synuclein alpha	Homo sapiens	47-50
8170996-4	1994	The latter value often has been used in model calculations of oxygen transport to tissue incorporating myoglobin-facilitated oxygen diffusion.	Oxygen	62-68	myoglobin	Homo sapiens	103-112
8170996-4	1994	The latter value often has been used in model calculations of oxygen transport to tissue incorporating myoglobin-facilitated oxygen diffusion.	Oxygen	125-131	myoglobin	Homo sapiens	103-112
25673207-0	2015	Time-dependent expression of PEDF and VEGF in blood serum and retina of rats with oxygen-induced retinopathy.	Oxygen	82-88	vascular endothelial growth factor A	Rattus norvegicus	38-42
8148375-0	1994	Characterisation of functional domains within the mouse erythropoietin 3" enhancer conveying oxygen-regulated responses in different cell lines.	Oxygen	93-99	erythropoietin	Mus musculus	56-70
8148375-1	1994	We have analysed sequences within the mouse erythropoietin enhancer which are required for oxygen regulated operation in the erythropoietin producing cell line, HepG2, and in two non-erythropoietin producing cell lines; the lung fibroblastoid cell line a23, and mouse erythroleukaemia (MEL) cells.	Oxygen	91-97	erythropoietin	Mus musculus	44-58
8148375-1	1994	We have analysed sequences within the mouse erythropoietin enhancer which are required for oxygen regulated operation in the erythropoietin producing cell line, HepG2, and in two non-erythropoietin producing cell lines; the lung fibroblastoid cell line a23, and mouse erythroleukaemia (MEL) cells.	Oxygen	91-97	erythropoietin	Mus musculus	125-139
8148375-1	1994	We have analysed sequences within the mouse erythropoietin enhancer which are required for oxygen regulated operation in the erythropoietin producing cell line, HepG2, and in two non-erythropoietin producing cell lines; the lung fibroblastoid cell line a23, and mouse erythroleukaemia (MEL) cells.	Oxygen	91-97	erythropoietin	Mus musculus	125-139
8148375-6	1994	Though operation of this 3" sequence differed according to the cell type, oxygen regulated operation was dependent on the same two critical sites in the 5" region in both erythropoietin producing and non-erythropoietin producing cells.	Oxygen	74-80	erythropoietin	Mus musculus	171-185
8148375-6	1994	Though operation of this 3" sequence differed according to the cell type, oxygen regulated operation was dependent on the same two critical sites in the 5" region in both erythropoietin producing and non-erythropoietin producing cells.	Oxygen	74-80	erythropoietin	Mus musculus	204-218
8971093-0	1997	Effect of granulocyte-colony stimulating factor on generation of oxygen-derived free radicals and myeloperoxidase activity in neutrophils from poorly controlled NIDDM patients.	Oxygen	65-71	colony stimulating factor 3	Homo sapiens	10-47
9368100-1	1997	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a basic helix-loop-helix-PAS (bHLH-PAS) transcription factor that mediates certain cellular responses to low oxygen tension, iron chelators, Co2+, Ni2+, Mg2+, and low intracellular glucose concentration.	Oxygen	159-165	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-32
25306858-9	2015	Moreover, the translational control of HIF2alpha mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply.	Oxygen	123-129	endothelial PAS domain protein 1	Homo sapiens	39-48
9368100-1	1997	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a basic helix-loop-helix-PAS (bHLH-PAS) transcription factor that mediates certain cellular responses to low oxygen tension, iron chelators, Co2+, Ni2+, Mg2+, and low intracellular glucose concentration.	Oxygen	159-165	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-45
8032542-0	1994	Mechanisms of interleukin-2-induced hydrothoraxy in mice: protective effect of endotoxin tolerance and dexamethasone and possible role of reactive oxygen intermediates.	Oxygen	147-153	interleukin 2	Mus musculus	14-27
25535359-4	2015	Mechanistically, TAp73 interacts with the regulatory subunit (alpha) of HIF-1 and recruits mouse double minute 2 homolog into the protein complex, thus promoting HIF-1alpha polyubiquitination and consequent proteasomal degradation in an oxygen-independent manner.	Oxygen	237-243	transformation related protein 73	Mus musculus	17-22
8160879-1	1994	Experiments were conducted in 63 dogs to determine whether stimulation of vagal tone contributes to the decrease in O2 consumption (VO2) that results from arginine vasopressin (AVP) administration.	Oxygen	116-118	arginine vasopressin	Canis lupus familiaris	177-180
8166301-0	1994	Interleukin-1alpha induced protection against pulmonary oxygen toxicity.	Oxygen	56-62	interleukin 1 alpha	Homo sapiens	0-18
9046048-4	1997	We found increased VEGF immunoreactivity in ganglion cells of rats with oxygen-induced ischemic retinopathy and in ganglion cells, the inner plexiform layer, and some cells in the inner nuclear layer of rats with experimental autoimmune uveoretinitis (EAU), in which there was no identifiable ischemia or NV.	Oxygen	72-78	vascular endothelial growth factor A	Rattus norvegicus	19-23
9120579-1	1997	In response to oxygen deprivation, CA1 pyramidal neurons show a hyperpolarization (hypoxic hyperpolarization), which is associated with a reduction in neuronal input resistance.	Oxygen	15-21	carbonic anhydrase 1	Rattus norvegicus	35-38
9011676-1	1997	Human thioredoxin is a polypeptide with thiol groups, possessing reducing activity, which is proved to have the ability to reduce active oxygens.	Oxygen	137-144	thioredoxin	Homo sapiens	6-17
9011676-10	1997	Among the ischemia groups, the human thioredoxin group showed significantly higher arterial oxygen tension at 30, 60, and 90 minutes after reperfusion than the control group, although there was no significant difference between the N-acetylcysteine and control groups.	Oxygen	92-98	thioredoxin	Homo sapiens	37-48
9011676-12	1997	In the measurement of active oxygens the chemiluminescence in the human thioredoxin group was less than that in the control group and as little as that in the group administered superoxide dismutase.	Oxygen	29-36	thioredoxin	Homo sapiens	72-83
9011676-13	1997	We concluded human thioredoxin attenuated ischemia-reperfusion injury by involving active oxygens in rabbit lungs.	Oxygen	90-97	thioredoxin	Homo sapiens	19-30
8023703-1	1994	The phenomenon was oxygen-dependent, and the intensity of emission could be suppressed by post-irradiation treatment with catalase, superoxide dismutase, and ascorbic acid.	Oxygen	19-25	superoxide dismutase	Cicer arietinum	132-152
25816927-6	2015	Depending on the state of the sapphire tip, we resolve either the calcium or the oxygen sublattice.	Oxygen	81-87	TOR signaling pathway regulator	Homo sapiens	39-42
8306676-16	1994	CONCLUSIONS: The regulation of IL-2 transcription in the T lymphocyte appears to be exquisitely sensitive to changes in oxygen tension.	Oxygen	120-126	interleukin 2	Mus musculus	31-35
9406238-3	1997	A major control of HIF-1 activity by oxygen tension is achieved by changes in the level of the HIF-1 alpha subunit, which complexes with the constitutively expressed HIF-1 beta subunit.	Oxygen	37-43	hypoxia inducible factor 1, alpha subunit	Mus musculus	95-106
9406238-3	1997	A major control of HIF-1 activity by oxygen tension is achieved by changes in the level of the HIF-1 alpha subunit, which complexes with the constitutively expressed HIF-1 beta subunit.	Oxygen	37-43	aryl hydrocarbon receptor nuclear translocator	Mus musculus	166-176
26656812-6	2015	Hydrogen peroxide, oxygen, and nitrite were electrochemically catalyzed by the Mb-CA"s composite film with significant lowering of the reduction overpotential.	Oxygen	19-25	myoglobin	Homo sapiens	79-81
9066048-2	1997	Production of O2- was diminished in cultures of macrophages supplemented with lactoferrin and the effect of lactoferrin was dose and time dependent.	Oxygen	14-16	lactotransferrin	Bos taurus	78-89
9066048-2	1997	Production of O2- was diminished in cultures of macrophages supplemented with lactoferrin and the effect of lactoferrin was dose and time dependent.	Oxygen	14-16	lactotransferrin	Bos taurus	108-119
8076624-11	1994	Group AnT attained the same maximum performance data (maximum running speed, maximum rate of O2 consumption) as group AeT.	Oxygen	93-95	solute carrier family 25 member 6	Homo sapiens	6-9
24597567-0	2015	PEGylation of alphaalpha-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG alphaalpha-Hbs.	Oxygen	141-147	progestagen associated endometrial protein	Homo sapiens	0-3
7894046-3	1994	The drug also inhibited the oxygen-dependent secretion of erythropoietin (estimated by the plasma immunoreactive hormone concentration) in hypoxemic mice when injected between 0 and 2 h after initiation of the hypoxic stimulation.	Oxygen	28-34	erythropoietin	Mus musculus	58-72
8056881-1	1994	At the end of incubation, the partial pressures of oxygen and carbon dioxide in the air cell of sea-level avian eggs are similar to those in the expiratory air of adult birds.	Oxygen	51-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
9003470-0	1996	Increased microvascular permeability induced by prolonged interleukin-2 administration is attenuated by the oxygen-free-radical scavenger dimethylthiourea.	Oxygen	108-114	interleukin 2	Mus musculus	58-71
9010748-14	1996	In this signal transduction mechanism, the ArcB C-terminal or "receiver" domain plays a critical role; that is, it stimulates or abolishes the transphosphorylation depending on the metabolic state of the cell, which in turn is influenced by the availability of oxygen.	Oxygen	261-267	hypothetical protein	Escherichia coli	43-47
24597567-0	2015	PEGylation of alphaalpha-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG alphaalpha-Hbs.	Oxygen	141-147	progestagen associated endometrial protein	Homo sapiens	62-65
24597567-0	2015	PEGylation of alphaalpha-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG alphaalpha-Hbs.	Oxygen	141-147	progestagen associated endometrial protein	Homo sapiens	62-65
24597567-2	2015	New hexa and deca PEGylated low oxygen affinity PEG-alphaalphaHbs have been generated.	Oxygen	32-38	progestagen associated endometrial protein	Homo sapiens	18-21
8938736-7	1996	Oxygen interruption during application of either baclofen (n = 6) or (D-Ala2-N-Me-Phe,Gly-ol)enkephalin (n = 4) blocked the depressant action of both drugs on the field inhibitory postsynaptic potential.	Oxygen	0-6	proenkephalin	Rattus norvegicus	93-103
24597567-4	2015	The results have established that in the design of PEG-Hbs as oxygen therapeutics, the influence of conjugation chemistry and the PEG shell structure on the oxygen affinity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.	Oxygen	62-68	progestagen associated endometrial protein	Homo sapiens	51-54
24597567-4	2015	The results have established that in the design of PEG-Hbs as oxygen therapeutics, the influence of conjugation chemistry and the PEG shell structure on the oxygen affinity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.	Oxygen	157-163	progestagen associated endometrial protein	Homo sapiens	51-54
24597567-4	2015	The results have established that in the design of PEG-Hbs as oxygen therapeutics, the influence of conjugation chemistry and the PEG shell structure on the oxygen affinity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.	Oxygen	157-163	progestagen associated endometrial protein	Homo sapiens	130-133
8917642-5	1996	From the modeling analysis, we found that the carbonyl oxygen of the N-acetyl group of GlcNAc in 3 formed a hydrogen bond with the amide group of Asn 82 in P-selectin.	Oxygen	55-61	selectin P	Homo sapiens	156-166
24597567-4	2015	The results have established that in the design of PEG-Hbs as oxygen therapeutics, the influence of conjugation chemistry and the PEG shell structure on the oxygen affinity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.	Oxygen	157-163	progestagen associated endometrial protein	Homo sapiens	130-133
8968975-2	1996	Since hemoglobin, myoglobin, and cytochrome c oxidase are the only biological compounds to exhibit variable absorption of near-infrared (NIR) light in response to changes in oxygen availability, NIRS can determine changes in tissue oxygenation.	Oxygen	174-180	myoglobin	Homo sapiens	18-27
8923780-6	1996	Our findings support the hypothesis that GATA is a transcription factor for the Epo gene acting through the oxygen sensor.	Oxygen	108-114	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	41-45
9308339-6	1996	Oxygen increased GST activity in the brain and reduced glutathione peroxidase (GPX) activity in the kidney.	Oxygen	0-6	hematopoietic prostaglandin D synthase	Rattus norvegicus	17-20
25962702-5	2015	In isolated working hearts, a decrease in cardiac function in SIRT3(-/-) mice was accompanied by a decrease in palmitate oxidation, glucose oxidation, and oxygen consumption, whereas rates of glycolysis were increased.	Oxygen	155-161	sirtuin 3	Mus musculus	62-67
8902948-8	1996	Increase in [Ca2+]i due to oxygen-glucose deprivation was significant in CA1 and CA3 of the septic group and in all hippocampal regions of sham-operated group.	Oxygen	27-33	carbonic anhydrase 1	Rattus norvegicus	73-76
25982881-4	2015	In isolated working hearts in mice lacking AdipoR1, myocardial oxygen consumption was increased without a concomitant increase in cardiac work, resulting in reduced cardiac efficiency.	Oxygen	63-69	adiponectin receptor 1	Mus musculus	43-50
8910864-0	1996	Trifluoperazine is more effective than chlorpromazine in releasing oxygen from haemoglobin and myoglobin.	Oxygen	67-73	myoglobin	Homo sapiens	95-104
8910864-1	1996	The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5-1000 microM).	Oxygen	14-20	myoglobin	Homo sapiens	69-78
25832631-3	2015	In addition, we found that the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which accumulates in cells under hypoxic conditions, was significantly increased in the colons of mice with food intake, indicating that the oxygen concentration is likely reduced in the colon after eating.	Oxygen	232-238	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-76
25832631-3	2015	In addition, we found that the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which accumulates in cells under hypoxic conditions, was significantly increased in the colons of mice with food intake, indicating that the oxygen concentration is likely reduced in the colon after eating.	Oxygen	232-238	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-88
25355806-0	2015	Toll-like receptor 3 activation drives the inflammatory response in oxygen-induced retinopathy in rats.	Oxygen	68-74	toll-like receptor 3	Rattus norvegicus	0-20
8960388-13	1996	It is concluded that the toxicity of ACE inhibitors may be related to those effects in the ewe that lead to reduced fetal arterial oxygen levels and increased fetal plasma K levels.	Oxygen	131-137	angiotensin-converting enzyme	Ovis aries	37-40
8760986-7	1996	In the patient"s group, there were significant inverse correlates between von Willebrand factor and percutaneous oxygen (p = 0.004) and between soluble thrombomodulin and percutaneous oxygen (p = 0.011) while elastase correlated positively with soluble thrombomodulin (p = 0.023).	Oxygen	184-190	thrombomodulin	Homo sapiens	152-166
25355806-2	2015	The purpose of this study was to investigate the potential role and mechanisms by which toll-like receptor 3 (TLR3) influences the progression of the inflammatory response in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	190-196	toll-like receptor 3	Rattus norvegicus	88-108
25355806-2	2015	The purpose of this study was to investigate the potential role and mechanisms by which toll-like receptor 3 (TLR3) influences the progression of the inflammatory response in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	190-196	toll-like receptor 3	Rattus norvegicus	110-114
8760546-14	1996	In patients with complete healing, the BPI was constantly greater than 0.9 to 2.5 ata O2 during the following sessions, whereas the BPI in air progressively rose between the first and the twelfth sessions (p &lt; 0.05), reaching normal values at the end of the treatment.	Oxygen	86-88	bactericidal permeability increasing protein	Homo sapiens	39-42
25348671-9	2015	Our findings suggest that Oct-3/4-expressing glioblastoma cells have the ability to adapt to low-oxygen environments within tumor masses by promoting tumor angiogenesis through AKT-HIF1 pathway.	Oxygen	97-103	POU class 5 homeobox 1	Homo sapiens	26-33
25448009-4	2015	A 3-min hypoxic episode (12-14% O2) always triggered STP of inspiratory burst amplitude, the magnitude of which was greater in phrenic bursting ipsilateral vs. contralateral to C2Hx.	Oxygen	32-34	complement C2	Rattus norvegicus	177-181
8709123-6	1996	The enzyme tolerates changing the C-4 oxygen of uridine to an amino group as well as substituting groups containing one or two carbons at C-5.	Oxygen	38-44	complement C4A (Rodgers blood group)	Homo sapiens	34-37
8709123-6	1996	The enzyme tolerates changing the C-4 oxygen of uridine to an amino group as well as substituting groups containing one or two carbons at C-5.	Oxygen	38-44	complement C5	Homo sapiens	138-141
25338643-7	2015	Autoacetylation stimulated the catalytic activity of mARD1(225) to acetylate Lys532 of the oxygen-dependent degradation (ODD) domain of HIF-1alpha, leading to the proteosomal degradation of HIF-1alpha.	Oxygen	91-97	N(alpha)-acetyltransferase 10, NatA catalytic subunit	Mus musculus	53-58
8760144-1	1996	The expression of insulin-like growth factor I (IGF-I) and insulin-like growth factor II (IGF-II) was studied in the lungs of adult rats exposed to air or 85% O2, using Northern analysis, in situ hybridization, and immunohistochemistry.	Oxygen	159-161	insulin-like growth factor 1	Rattus norvegicus	18-46
8760144-5	1996	A widespread increase in IGF-I mRNA and peptide was seen after both a 6-day and a 14-day exposure to O2, with maximal expression in the airway and alveolar epithelium, and lesser expression in interstitial cells.	Oxygen	101-103	insulin-like growth factor 1	Rattus norvegicus	25-30
8766002-1	1996	This study sought to investigate whether a common protein kinase activity is involved in the sequence of events by which oxygen controls the expression of the genes for erythropoietin (EPO) and for vascular endothelial growth factor (VEGF) in rat hepatocytes.	Oxygen	121-127	erythropoietin	Rattus norvegicus	169-183
8766002-1	1996	This study sought to investigate whether a common protein kinase activity is involved in the sequence of events by which oxygen controls the expression of the genes for erythropoietin (EPO) and for vascular endothelial growth factor (VEGF) in rat hepatocytes.	Oxygen	121-127	erythropoietin	Rattus norvegicus	185-188
25338643-7	2015	Autoacetylation stimulated the catalytic activity of mARD1(225) to acetylate Lys532 of the oxygen-dependent degradation (ODD) domain of HIF-1alpha, leading to the proteosomal degradation of HIF-1alpha.	Oxygen	91-97	hypoxia inducible factor 1, alpha subunit	Mus musculus	136-146
8766002-1	1996	This study sought to investigate whether a common protein kinase activity is involved in the sequence of events by which oxygen controls the expression of the genes for erythropoietin (EPO) and for vascular endothelial growth factor (VEGF) in rat hepatocytes.	Oxygen	121-127	vascular endothelial growth factor A	Rattus norvegicus	198-232
8766002-1	1996	This study sought to investigate whether a common protein kinase activity is involved in the sequence of events by which oxygen controls the expression of the genes for erythropoietin (EPO) and for vascular endothelial growth factor (VEGF) in rat hepatocytes.	Oxygen	121-127	vascular endothelial growth factor A	Rattus norvegicus	234-238
8766002-3	1996	We found that 3 h of exposure to the low O2 tension increased EPO mRNA levels about 20-fold and the three VEGF (-180, -164, -120) mRNA levels, on average, about fourfold.	Oxygen	41-43	erythropoietin	Rattus norvegicus	62-65
8766002-5	1996	In the presence of 1% O2, genistein decreased EPO mRNA and VEGF mRNA levels with IC50 values of about 36 and 360 microM, respectively.	Oxygen	22-24	erythropoietin	Rattus norvegicus	46-49
8662957-2	1996	Hypoxia-inducible factor-1 (HIF-1), a DNA-binding complex implicated in the regulation of gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1alpha, and HIF-1beta.	Oxygen	109-115	aryl hydrocarbon receptor nuclear translocator	Mus musculus	198-202
8662957-2	1996	Hypoxia-inducible factor-1 (HIF-1), a DNA-binding complex implicated in the regulation of gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1alpha, and HIF-1beta.	Oxygen	109-115	hypoxia inducible factor 1, alpha subunit	Mus musculus	223-233
25338643-7	2015	Autoacetylation stimulated the catalytic activity of mARD1(225) to acetylate Lys532 of the oxygen-dependent degradation (ODD) domain of HIF-1alpha, leading to the proteosomal degradation of HIF-1alpha.	Oxygen	91-97	hypoxia inducible factor 1, alpha subunit	Mus musculus	190-200
25313472-2	2015	The specific hypothesis is that PPA can be readily grafted onto the face surfaces of exfoliated HCN, which has reactive apical oxygen atoms.	Oxygen	127-133	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	96-99
8660378-1	1996	The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-regulated transcription of several genes including erythropoietin.	Oxygen	82-88	erythropoietin	Mus musculus	140-154
8687376-6	1996	It was reported that the activity of Egr-1 protein as a transcription factor was negatively regulated by active oxygens.	Oxygen	112-119	early growth response 1	Homo sapiens	37-42
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	86-88	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-19
8668123-1	1996	We have previously reported that the Saccharomyces cerevisiae CRS5 metallothionein gene is negatively regulated by oxygen.	Oxygen	115-121	CRS5	Saccharomyces cerevisiae S288C	62-66
25866226-13	2015	Breast cancer cells in vitro showed that HIF-2alpha, CA-9 or CA-12 had an increase expression under hypoxia (1% O2).	Oxygen	112-114	endothelial PAS domain protein 1	Homo sapiens	41-51
25315681-5	2015	We tested the hypothesis that hiPSC-derived neuroprogenitors from patients with PARK2 mutations would show heightened cell death, mitochondrial dysfunction, and reactive oxygen species generation compared to control cells as a result of exposure to heavy metals (PD environmental risk factors).	Oxygen	170-176	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	80-85
9081618-5	1996	Exposure to a low level of oxygen led to elevated erythropoietin mRNA levels in the monkey brain, as did anaemia in the mouse brain.	Oxygen	27-33	erythropoietin	Mus musculus	50-64
9081618-8	1996	When incubated at 1% oxygen, astrocytes showed &gt;100-fold time-dependent erythropoietin mRNA accumulation, as measured with the quantitative reverse transcription-polymerase chain reaction.	Oxygen	21-27	erythropoietin	Mus musculus	75-89
8172562-9	1993	Preincubation of serum treated Hib with C1q significantly enhanced the O2-metabolism of polymorphonuclear leucocytes in chemiluminescence assay.	Oxygen	71-73	complement C1q A chain	Homo sapiens	40-43
25387795-0	2014	A rare tetranuclear thorium(IV) mu4 -oxo cluster and dinuclear thorium(IV) complex assembled by carbon-oxygen bond activation of 1,2-dimethoxyethane (DME).	Oxygen	103-109	adaptor related protein complex 4 subunit mu 1	Homo sapiens	32-35
7510548-6	1993	P-Selectin, however, requires only the 3-position hydroxyl group, while tolerating removal of the oxygen at positions 2 or 4 of fucose residue.	Oxygen	98-104	selectin P	Homo sapiens	0-10
11725090-5	1996	The antagonist-binding pocket of the human 5-HT(1A)R is inferred from the interaction sites of pindolol with the receptor model: (1) the ionic interaction between the protonated amine of the ligand and the side chain of the conserved Asp-116, located in TMH 3; and (2) the hydrogen bonds between the ether oxygen and the hydroxyl group of the ligand and Asn-385, located in TMH 7.	Oxygen	306-312	5-hydroxytryptamine receptor 1A	Homo sapiens	43-50
25446085-3	2014	However, the identification and validation of UQCRB as a target protein of terpestacin enabled the role of UQCRB in oxygen sensing and angiogenesis to be elucidated.	Oxygen	116-122	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	46-51
8738394-4	1996	When cerebral metabolic rate of oxygen is constant, changes in arterio-jugular differences of oxygen (AVDO2) reflect changes in CBF.	Oxygen	32-38	CCAAT enhancer binding protein zeta	Homo sapiens	128-131
8738394-4	1996	When cerebral metabolic rate of oxygen is constant, changes in arterio-jugular differences of oxygen (AVDO2) reflect changes in CBF.	Oxygen	94-100	CCAAT enhancer binding protein zeta	Homo sapiens	128-131
8245781-6	1993	We report here that the capacity for O2- production and cytochrome b558 protein expression were restored to Epstein-Barr virus-transformed B lymphocytes from two A22(0) CGD patients by transfection with an expression plasmid containing a p22phox cDNA.	Oxygen	37-39	cytochrome b-245 alpha chain	Homo sapiens	238-245
8246884-1	1993	In Saccharomyces cerevisiae, hypusine-containing proteins are encoded by two closely related genes, HYP1 and HYP2, which are regulated reciprocally by oxygen and heme.	Oxygen	151-157	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	109-113
25446085-3	2014	However, the identification and validation of UQCRB as a target protein of terpestacin enabled the role of UQCRB in oxygen sensing and angiogenesis to be elucidated.	Oxygen	116-122	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	107-112
25502559-5	2014	In this state, the core region of the ligand remains stable, notably because of the two anchoring oxygen atoms that correspond to recurrent motifs found in all FKBP12 ligand core structures.	Oxygen	98-104	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	160-166
8268807-0	1993	Application of molecular dynamics and free energy perturbation methods to metalloporphyrin-ligand systems II: CO and dioxygen binding to myoglobin.	Oxygen	117-125	myoglobin	Homo sapiens	137-146
8268807-1	1993	The protein contribution to the relative binding affinity of the ligands CO and O2 toward myoglobin (Mb) has been simulated using free energy perturbation calculations.	Oxygen	80-82	myoglobin	Homo sapiens	90-99
9090846-0	1996	Oxygen- and carbon source-dependent transactivation effect of ABF1 on the expression of the AAC2 gene encoding mitochondrial ADP/ATP carrier.	Oxygen	0-6	musculin	Homo sapiens	62-66
27406619-2	1996	The present study was thus designed to investigate EPO production during acute hypoxemia in a mouse model in which the oxygen-carrying capacity of blood, the plasma EPO level, and the plasma EPO half-life were within normal values in spite of a marked depression of the red cell production rate (RCPR) induced by cyclophosphamide (CP) administration.	Oxygen	119-125	erythropoietin	Mus musculus	51-54
27406619-5	1996	The results support the hypothesis that the EPO production rate in mammals is not only related to the oxygen supply to the tissues relative to their oxygen needs (main stimulus) but also to the erythroid activity of the marrow (modulatory action).	Oxygen	102-108	erythropoietin	Mus musculus	44-47
27406619-5	1996	The results support the hypothesis that the EPO production rate in mammals is not only related to the oxygen supply to the tissues relative to their oxygen needs (main stimulus) but also to the erythroid activity of the marrow (modulatory action).	Oxygen	149-155	erythropoietin	Mus musculus	44-47
9121606-3	1996	CA1 pyramidal neurons in oxygen-glucose deprived slices remained viable for up to 120 min following the insult but were dead by 240 min.	Oxygen	25-31	carbonic anhydrase 1	Rattus norvegicus	0-3
8054952-2	1993	High-dose oxygen, delivered under pressures greater than sea level, enables the body to increase diffusion of oxygen into tissues and stimulates angiogenesis and the immune response.	Oxygen	10-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
8054952-2	1993	High-dose oxygen, delivered under pressures greater than sea level, enables the body to increase diffusion of oxygen into tissues and stimulates angiogenesis and the immune response.	Oxygen	110-116	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
8369307-3	1993	Analysis of the kinetics of rHF and natural human liver ferritin (HLF) (4% H-chain, 96% L-chain) gave the following apparent parameters at pH 7: Km,O2 = 6 +/- 2 microM, Km,Fe = 80 +/- 10 microM, and kcat = 201 +/- 14 min-1 for rHF and Km,O2 = 60 +/- 12 microM, Km,Fe = 50 +/- 10 microM, and kcat = 31.2 +/- 0.6 min-1 for HLF.	Oxygen	148-150	HLF transcription factor, PAR bZIP family member	Homo sapiens	66-69
8369307-3	1993	Analysis of the kinetics of rHF and natural human liver ferritin (HLF) (4% H-chain, 96% L-chain) gave the following apparent parameters at pH 7: Km,O2 = 6 +/- 2 microM, Km,Fe = 80 +/- 10 microM, and kcat = 201 +/- 14 min-1 for rHF and Km,O2 = 60 +/- 12 microM, Km,Fe = 50 +/- 10 microM, and kcat = 31.2 +/- 0.6 min-1 for HLF.	Oxygen	238-240	HLF transcription factor, PAR bZIP family member	Homo sapiens	66-69
26583221-2	2014	For a &gt;1000 atom model of the oxygenated myoglobin protein, the DDEC/c3 net charge of the adsorbed oxygen molecule is approximately -1e (in agreement with the Weiss model) using a dynamical mean field theory treatment of the iron atom, but much smaller in magnitude when using the generalized gradient approximation.	Oxygen	33-39	myoglobin	Homo sapiens	44-53
8343616-0	1993	The role of myoglobin in retarding oxygen depletion in skeletal muscle.	Oxygen	35-41	myoglobin	Homo sapiens	12-21
8343616-1	1993	Myoglobin retards the development of anoxia in a poorly perfused region of skeletal muscle by facilitating diffusion into this region from adjacent normally perfused regions and by releasing bound oxygen directly into the tissue.	Oxygen	197-203	myoglobin	Homo sapiens	0-9
8343616-2	1993	We examine these phenomena by analyzing a mathematical model of time-dependent myoglobin-facilitated oxygen transport.	Oxygen	101-107	myoglobin	Homo sapiens	79-88
8343616-4	1993	We find that when perfusion of a region is suddenly decreased, oxygen depletion is significantly retarded by direct release of myoglobin-bound oxygen into the tissue and that myoglobin-facilitated diffusion of oxygen from adjacent regions becomes significant at very low oxygen concentration.	Oxygen	63-69	myoglobin	Homo sapiens	127-136
10387976-31	1996	G-CSF also enhances neutrophil function in the presence of bacterial products, and it acts on mature neutrophils to enhance cellular motility, the production of bioactive oxygen, and microbicidal activity.	Oxygen	171-177	colony stimulating factor 3	Homo sapiens	0-5
9085366-0	1996	Products of red blood cell degradation inhibit responsiveness of the erythropoietin oxygen sensor.	Oxygen	84-90	erythropoietin	Mus musculus	69-83
8343616-4	1993	We find that when perfusion of a region is suddenly decreased, oxygen depletion is significantly retarded by direct release of myoglobin-bound oxygen into the tissue and that myoglobin-facilitated diffusion of oxygen from adjacent regions becomes significant at very low oxygen concentration.	Oxygen	143-149	myoglobin	Homo sapiens	127-136
25446002-7	2014	In addition, an alpha-Syn/N-induced increase in the level of intracellular reactive oxygen species, alteration in mitochondrial morphology, and decrease in mitochondrial membrane potential were accompanied by the activation of mitochondrial permeability transition pores (mPTP).	Oxygen	84-90	synuclein, alpha	Mus musculus	16-27
8343616-4	1993	We find that when perfusion of a region is suddenly decreased, oxygen depletion is significantly retarded by direct release of myoglobin-bound oxygen into the tissue and that myoglobin-facilitated diffusion of oxygen from adjacent regions becomes significant at very low oxygen concentration.	Oxygen	143-149	myoglobin	Homo sapiens	127-136
8343616-4	1993	We find that when perfusion of a region is suddenly decreased, oxygen depletion is significantly retarded by direct release of myoglobin-bound oxygen into the tissue and that myoglobin-facilitated diffusion of oxygen from adjacent regions becomes significant at very low oxygen concentration.	Oxygen	143-149	myoglobin	Homo sapiens	127-136
8768334-0	1996	[A comparative ontogenic analysis of the correlative characteristics between oxygen consumption and the catecholamine level of the blood and its cholinesterase activity at different age periods].	Oxygen	77-83	butyrylcholinesterase	Homo sapiens	145-159
25053119-7	2014	IkappaBalpha overexpression reduced the alveolar-arterial oxygen gradient (kPa) at both the lower [53 (21)] and higher [52 (19)] doses compared with vehicle [75 (8.5)] or the null transgene [70 (15)], decreased alveolar neutrophil infiltration, and reduced alveolar concentrations of interleukin (IL)-1beta and IL-10.	Oxygen	58-64	NFKB inhibitor alpha	Rattus norvegicus	0-12
8904017-10	1995	The eLa increase in C is associated with an impaired muscle blood flow and decreased muscle O2 unloading, and does not completely explain the greater O2 deficit in C. The unexplained fraction of the latter is perhaps accounted for by a greater net alactic O2 deficit, in agreement with a temperature-dependent decrease of the velocity constants of oxidative reactions, as suggested by the tested hypothesis.	Oxygen	92-94	apelin receptor early endogenous ligand	Homo sapiens	4-7
11607591-7	1995	At a low CO2/high O2 ratio that inhibits the carboxylase activity of Rubisco, much malate accumulates, which suggests that the oxygen-insensitive phosphoenolpyruvate carboxylase becomes a significant component of the lower CO2 fixation rate.	Oxygen	10-12	phosphoenolpyruvate carboxykinase 1	Homo sapiens	146-177
11607591-7	1995	At a low CO2/high O2 ratio that inhibits the carboxylase activity of Rubisco, much malate accumulates, which suggests that the oxygen-insensitive phosphoenolpyruvate carboxylase becomes a significant component of the lower CO2 fixation rate.	Oxygen	127-133	phosphoenolpyruvate carboxykinase 1	Homo sapiens	146-177
7499243-8	1995	Northern analyses revealed that NNE mRNA hypoxic up-regulation began at 1-2 h, peaked at 18 h, persisted for 48 h, and returned to base line after return to 21% O2 for 24 h. Hypoxia maximally up-regulated NNE mRNA levels 3.4-fold.	Oxygen	161-163	enolase 1	Bos taurus	32-35
7488134-2	1995	Expression of the subunit VI encoding gene, COX6, is glucose repressed, growth phase induced, and dependent on oxygen and heme availability.	Oxygen	111-117	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	44-48
7488164-0	1995	Oxygen regulation of the cytochrome c oxidase subunit VI gene, COX6, in Saccharomyces cerevisiae.	Oxygen	0-6	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	25-56
7488164-0	1995	Oxygen regulation of the cytochrome c oxidase subunit VI gene, COX6, in Saccharomyces cerevisiae.	Oxygen	0-6	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	63-67
7488164-3	1995	We focused on the subunit VI encoding gene, COX6, and detected unexpectedly complex oxygen regulation.	Oxygen	84-90	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	44-48
7488164-4	1995	We found that COX6 transcription possessed a critical threshold oxygen regulation between 0 and 2%.	Oxygen	64-70	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	14-18
7488164-5	1995	COX6 transcription was superinduced by elevated oxygen level up to 45%; however, superinduction was lost at 60% oxygen and above.	Oxygen	48-54	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	0-4
7488164-5	1995	COX6 transcription was superinduced by elevated oxygen level up to 45%; however, superinduction was lost at 60% oxygen and above.	Oxygen	112-118	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	0-4
7488164-6	1995	The COX6 upstream activation region, UAS6, contains both glucose and heme responsive regions, and COX6 oxygen regulation was transduced through UAS6 by heme, as has been described for other oxygen regulated genes in yeast.	Oxygen	103-109	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	98-102
7503328-2	1995	With the use of the ribonuclease protection assay to quantify RNA, both hypoxia (0.1% CO or 9% O2) and cobalt (60 mg/kg) elicit production of increased amounts of EPO mRNA in neonatal and juvenile rat liver in vivo.	Oxygen	95-97	erythropoietin	Rattus norvegicus	163-166
7503328-3	1995	In vitro hepatocyte EPO gene expression could be reproducibly stimulated by hypoxia (3% O2) but not by cobaltous chloride (50-150 microM) within 2-20 h. Conversely, cobalt substantially attenuated the rise of EPO mRNA levels in response to hypoxia.	Oxygen	88-90	erythropoietin	Rattus norvegicus	20-23
8576720-5	1995	RESULTS: At jet cycle rates of 20 cycles/min, end-tidal oxygen (ETO2) concentration indicated alveolar hypoxia 30 to 60 sec before hypoxemia was detected by pulse oximetry.	Oxygen	56-62	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	64-68
8576720-7	1995	Correlations between ETO2 concentrations, oxygen saturations, and arterial oxygen levels depended on respiratory rate and inspiratory oxygen concentration; correlations were stronger at low than at high inspiratory oxygen concentrations and stronger at low than at high respiratory rates.	Oxygen	75-81	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	21-25
8576720-7	1995	Correlations between ETO2 concentrations, oxygen saturations, and arterial oxygen levels depended on respiratory rate and inspiratory oxygen concentration; correlations were stronger at low than at high inspiratory oxygen concentrations and stronger at low than at high respiratory rates.	Oxygen	75-81	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	21-25
8576720-7	1995	Correlations between ETO2 concentrations, oxygen saturations, and arterial oxygen levels depended on respiratory rate and inspiratory oxygen concentration; correlations were stronger at low than at high inspiratory oxygen concentrations and stronger at low than at high respiratory rates.	Oxygen	75-81	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	21-25
8545005-1	1995	Hippocampal slices were transiently exposed to an oxygen- and glucose-free environment which causes a pronounced drop of both ATP and creatine phosphate, an anoxic depolarization, and an incomplete recovery of synaptically evoked population spike in the CA1 region after 1 h (48.5 +/- 3.6% of baseline values).	Oxygen	50-56	carbonic anhydrase 1	Rattus norvegicus	254-257
10059267-0	1995	High fractions of negative ions in grazing scattering of fast oxygen atoms from a LiF(100) surface.	Oxygen	62-68	LIF interleukin 6 family cytokine	Homo sapiens	82-85
7549099-3	1995	Furthermore, the oxygen consumption in rat liver mitochondria that was accelerated during incubation, which implies an increase in the permeability of the inner membrane, was suppressed by the addition of A1a and A1a/Try.	Oxygen	17-23	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	205-208
7549099-3	1995	Furthermore, the oxygen consumption in rat liver mitochondria that was accelerated during incubation, which implies an increase in the permeability of the inner membrane, was suppressed by the addition of A1a and A1a/Try.	Oxygen	17-23	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	213-216
8610070-5	1995	In order to eliminate false results caused by tyrosinase inhibition, which also will decrease the dopachrome concentration, the oxygen consumption was followed potentiometrically.	Oxygen	128-134	tyrosinase	Mus musculus	46-56
7558244-4	1995	Under standard in vitro conditions (21% O2) VEGF expression in astrocytes in barely detectable by northern analysis.	Oxygen	40-42	vascular endothelial growth factor A	Rattus norvegicus	44-48
7558244-5	1995	However, after exposure to 0.2% O2 for as little as 3 h VEGF mRNA levels are markedly increased reaching a maximum by approximately 8 h of exposure.	Oxygen	32-34	vascular endothelial growth factor A	Rattus norvegicus	56-60
7558244-6	1995	Treatment of astrocytes with CoCl2 or desferrioxamine results in a similar induction of VEGF, suggesting that the oxygen sensor regulating VEGF expression in astrocytes is a heme-containing molecule.	Oxygen	114-120	vascular endothelial growth factor A	Rattus norvegicus	88-92
7558244-6	1995	Treatment of astrocytes with CoCl2 or desferrioxamine results in a similar induction of VEGF, suggesting that the oxygen sensor regulating VEGF expression in astrocytes is a heme-containing molecule.	Oxygen	114-120	vascular endothelial growth factor A	Rattus norvegicus	139-143
7785012-10	1995	In Exp 1 the arterial oxygen tension (PaO2) on air in the hTRX group was higher at 20 minutes than at one minute after reperfusion.	Oxygen	22-28	exportin 1	Homo sapiens	3-8
7785012-10	1995	In Exp 1 the arterial oxygen tension (PaO2) on air in the hTRX group was higher at 20 minutes than at one minute after reperfusion.	Oxygen	22-28	thioredoxin	Homo sapiens	58-62
7832763-4	1995	hCOX-1 had a specific activity of 18.8 mumol of O2/mg with a Km of 13.8 microM for arachidonate and Vmax.	Oxygen	48-50	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-6
8521084-5	1995	However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved: how and at which subcellular level, do the cells produce these reactive oxygen intermediates that will contribute to NF kappa B activation in response to IL-1 or TNF-alpha?	Oxygen	207-213	interleukin 1 alpha	Homo sapiens	289-293
7745227-8	1995	Exposure to 95% O2 for 3 days was associated with a significant decrease in ATP cell content, protein, catalase and GSH to the total glutathione ratio, whereas SOD, GSH and total glutathione did not change significantly.	Oxygen	16-18	catalase	Cavia porcellus	103-111
7603300-6	1995	In contrast, the lower affinity receptor, VN2 induces vasoconstriction associated with inhibition of oxygen consumption.	Oxygen	101-107	vomeronasal 1 receptor 102	Rattus norvegicus	42-45
7983043-1	1994	The low frequency resonance Raman spectra of the dioxygen adducts of myoglobin, hemoglobin, its isolated subunits, mesoheme-substituted hemoglobin, and several deuteriated heme derivatives are reported.	Oxygen	49-57	myoglobin	Homo sapiens	69-78
7696460-8	1994	These included a salt link between arginine L34 and one of fluorescein"s enolate oxygen atoms, a hydrogen bond between histidine L27d and the second enolic group, a hydrogen bond between tyrosine L32 and the phenylcarboxylate group, and two medium range (approximately 5 A) electrostatic interactions with lysine L50 and arginine H52.	Oxygen	81-87	ribosomal protein L34	Homo sapiens	44-47
24226516-6	1994	The MP2 TS leads directly to fragmentation and is described as a protonation of the methyl group by the acidic proton on oxygen.	Oxygen	121-127	tryptase pseudogene 1	Homo sapiens	4-7
7964505-20	1994	We suggest that the binding of an SH3 domain of p47-phox to p22-phox, and thus activation of the oxidase, does not occur in the neutrophils of this patient, although under artificial conditions, electron flow from NADPH to oxygen in cytochrome b558 is possible.	Oxygen	223-229	pleckstrin	Homo sapiens	48-51
7979387-4	1994	The specific cyclooxygenase activities of both enzymes are 43 mumol O2/min/mg with arachidonic acid which is within the range of values reported for ovine Cox-1.	Oxygen	68-70	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	155-160
7811967-5	1994	In pericarp tissue of fruit, the Adh2 mRNA level increased to a maximum within 8-16 h of exposure to atmospheres with 3% (v/v) oxygen, and returned to the basal level within 16 h of a return to air.	Oxygen	127-133	alcohol dehydrogenase 2	Solanum lycopersicum	33-37
8513773-3	1993	In this study, the oxygen uptake per unit CW (VO2 x CW-1) of seven trained bicycle racers (5 men, 2 women, 24 +/- 2 years) was measured while each cycled up a 4% incline at 19.3 km.h-1 and 75 revolutions.min-1 on a motor-driven treadmill, using randomly-ordered tyre pressures of 552, 690, 827, and 965 kPa.	Oxygen	19-25	dynein light chain Tctex-type 1	Homo sapiens	52-56
8396560-0	1993	Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2- generation by C4a.	Oxygen	79-81	complement C4-A	Cavia porcellus	97-100
8351193-0	1993	Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro.	Oxygen	0-6	erythropoietin	Rattus norvegicus	35-49
8351193-1	1993	Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.	Oxygen	210-216	erythropoietin	Rattus norvegicus	76-79
8351193-1	1993	Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.	Oxygen	210-216	erythropoietin	Rattus norvegicus	227-230
8351193-2	1993	When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, as determined by RNas protection.	Oxygen	52-58	erythropoietin	Rattus norvegicus	113-116
8351193-2	1993	When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, as determined by RNas protection.	Oxygen	52-58	erythropoietin	Rattus norvegicus	148-151
8351193-3	1993	This increase was maximal at 3% O2, where EPO mRNA levels after 18 h were approximately 15-fold higher than at 20% O2.	Oxygen	32-34	erythropoietin	Rattus norvegicus	42-45
8351193-4	1993	The increase in EPO mRNA at low oxygen tensions was specific insofar as [3H]uridine incorporation, as a measure of total RNA synthesis, was reduced by approximately 50% at 3% O2, and it appeared to involve gene transcription since it was abolished in the presence of actinomycin D (35 microM).	Oxygen	32-38	erythropoietin	Rattus norvegicus	16-19
8351193-4	1993	The increase in EPO mRNA at low oxygen tensions was specific insofar as [3H]uridine incorporation, as a measure of total RNA synthesis, was reduced by approximately 50% at 3% O2, and it appeared to involve gene transcription since it was abolished in the presence of actinomycin D (35 microM).	Oxygen	175-177	erythropoietin	Rattus norvegicus	16-19
8351193-5	1993	Significant increases in EPO mRNA were also observed in cells kept at 20% oxygen in the presence of cobalt chloride (50 microM) and nickel chloride (400 microM), but EPO mRNA levels achieved under these conditions were less than 7% of those in cells incubated at 3% oxygen.	Oxygen	74-80	erythropoietin	Rattus norvegicus	25-28
8351193-5	1993	Significant increases in EPO mRNA were also observed in cells kept at 20% oxygen in the presence of cobalt chloride (50 microM) and nickel chloride (400 microM), but EPO mRNA levels achieved under these conditions were less than 7% of those in cells incubated at 3% oxygen.	Oxygen	266-272	erythropoietin	Rattus norvegicus	25-28
8351193-7	1993	In the presence of 10% carbon monoxide, used to block haem proteins in their oxy conformation, EPO mRNA levels in hepatocytes incubated at low oxygen tensions were reduced to 63%.	Oxygen	143-149	erythropoietin	Rattus norvegicus	95-98
8353306-6	1993	These results suggest that EPO is expressed in an all-or-none fashion in peritubular interstitial cells and that the oxygen carrying capacity of blood is the major regulator of renal EPO production.	Oxygen	117-123	erythropoietin	Mus musculus	183-186
8479117-1	1993	We have used in situ hybridization to determine the localization and distribution of cells expressing the erythropoietin (EPO) gene in kidneys of rats exposed to reduced oxygen tensions to characterize the control of renal EPO formation during hypoxic hypoxia.	Oxygen	170-176	erythropoietin	Rattus norvegicus	106-120
8479117-1	1993	We have used in situ hybridization to determine the localization and distribution of cells expressing the erythropoietin (EPO) gene in kidneys of rats exposed to reduced oxygen tensions to characterize the control of renal EPO formation during hypoxic hypoxia.	Oxygen	170-176	erythropoietin	Rattus norvegicus	122-125
8479117-5	1993	After four hours of severe hypoxia (7.5% O2) approximately 170-fold more cells were found to contain EPO mRNA than under normoxic conditions.	Oxygen	41-43	erythropoietin	Rattus norvegicus	101-104
8479117-8	1993	Comparison of graded degrees of hypoxia applied for eight hours showed an inverse exponential relationship between oxygen tension and the number of EPO producing cells.	Oxygen	115-121	erythropoietin	Rattus norvegicus	148-151
8356473-4	1993	The results show that L-Enk content in the striatum and hypothalamus of rats exposed to hyperbaric oxygen environment were markedly higher than that of rats exposed to normobaric air and normoxic hyperbaric nitrox.	Oxygen	99-105	proenkephalin	Rattus norvegicus	24-27
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Oxygen	0-6	ceruloplasmin	Homo sapiens	30-43
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Oxygen	0-6	ceruloplasmin	Homo sapiens	173-186
8439010-0	1993	Toxin detection using a tyrosinase-coupled oxygen electrode.	Oxygen	43-49	tyrosinase	Serinus canaria	24-34
8439010-5	1993	Biocatalytic reduction of oxygen is promoted by electrochemically supplying tyrosinase with electrons.	Oxygen	26-32	tyrosinase	Serinus canaria	76-86
8130662-4	1993	The Baxter Asat 100 displayed a 25% lower functional oxygen saturation of haemoglobin (SaO2) compared to the Ohmeda Biox 3700 pulse oximeter.	Oxygen	53-59	ATP binding cassette subfamily B member 7	Homo sapiens	11-15
1469715-10	1992	The analysis of individual oxygen-induced TGR clones (48 h, 910 microM-O2) showed 43% had large gene alterations similar to the spontaneous TGR clones.	Oxygen	27-33	thioredoxin reductase 3	Homo sapiens	42-45
1453445-1	1992	Myoglobin extracted from the triturative stomach of Dolabella auricularia, a common mollusc found on the Japanese coast, possesses naturally occurring substitution at the distal E7 position (Val-E7) and its oxygen affinity is only slightly lower than those of the common mammalian myoglobins possessing the usual His-E7.	Oxygen	207-213	myoglobin	Homo sapiens	0-9
1474047-4	1992	The first signs of consciousness distortion in sea-level residents appeared at an end-tidal O2 pressure level (4.09 +/- 0.56 kPa) higher than that of temporary residents of middle (3.05 +/- 0.12) and high altitude (2.90 +/- 0.07).	Oxygen	92-94	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
1329105-12	1992	as an important mediator in CNS O2 toxicity and suggest that ECSOD increases CNS O2 toxicity by inhibiting O2(-)-mediated inactivation of NO.	Oxygen	81-83	superoxide dismutase 3, extracellular	Mus musculus	61-66
1328183-4	1992	First, oxygen transfer from the hemoprotein would occur to either C-1 or C-4 of 1,3-butadiene to form an intermediate which may cyclize to form BM or undergo a hydrogen shift to form 3-butenal, an unstable precursor of CA.	Oxygen	7-13	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	66-69
1328183-4	1992	First, oxygen transfer from the hemoprotein would occur to either C-1 or C-4 of 1,3-butadiene to form an intermediate which may cyclize to form BM or undergo a hydrogen shift to form 3-butenal, an unstable precursor of CA.	Oxygen	7-13	complement C4A (Rodgers blood group)	Homo sapiens	73-76
1302259-7	1992	However, severe hypoxia with 6% O2 increased the NA level from 30 to 66 nmol/l; the A level from 1 to 28 nmol/l and NPY from 140 to 213 pmol/l.	Oxygen	32-34	neuropeptide Y	Homo sapiens	116-119
1302259-9	1992	Theophylline moderately enhanced the release of NPY, NA and A during the 12% O2 challenge.	Oxygen	77-79	neuropeptide Y	Homo sapiens	48-51
1379088-4	1992	GM-CSF-, IL-3-, and IL-5-treated Eos-HL-60 cells showed increased O2- production in response to phorbol esters (PMA), enhanced phagocytosis of Candida albicans, and release of the enzymes arylsulfatase, beta-glucuronidase and eosinophil peroxidase (EPO).	Oxygen	66-68	colony stimulating factor 2	Homo sapiens	0-6
1379088-4	1992	GM-CSF-, IL-3-, and IL-5-treated Eos-HL-60 cells showed increased O2- production in response to phorbol esters (PMA), enhanced phagocytosis of Candida albicans, and release of the enzymes arylsulfatase, beta-glucuronidase and eosinophil peroxidase (EPO).	Oxygen	66-68	interleukin 3	Homo sapiens	9-13
1382400-1	1992	We examined in vitro the effect of G-CSF and temperature on superoxide (O2-) generation by Cypridina luciferin analog (CLA) dependent chemiluminescence.	Oxygen	72-74	colony stimulating factor 3	Homo sapiens	35-40
1382400-2	1992	PMN significantly generated O2- at the concentration of G-CSF 25 ng/ml or more at 37 degrees C within the range of 0.1 from 1,000 ng/ml.	Oxygen	28-30	colony stimulating factor 3	Homo sapiens	56-61
1382400-3	1992	O2- generation from PMN was remarkably enhanced, stimulated by opsonized zymosan (OZ) and phorbol myristate acetate (PMA), at 41 degrees C as compared with 37 degrees C. O2- generation was enhanced with the addition of 25 ng/ml of G-CSF at 41 degrees C as compared to without it at 41 degrees C. A significant enhancement of O2- generation from PMN was observed at 25 ng/ml G-CSF and 41 degrees C.	Oxygen	0-2	colony stimulating factor 3	Homo sapiens	231-236
1382400-3	1992	O2- generation from PMN was remarkably enhanced, stimulated by opsonized zymosan (OZ) and phorbol myristate acetate (PMA), at 41 degrees C as compared with 37 degrees C. O2- generation was enhanced with the addition of 25 ng/ml of G-CSF at 41 degrees C as compared to without it at 41 degrees C. A significant enhancement of O2- generation from PMN was observed at 25 ng/ml G-CSF and 41 degrees C.	Oxygen	0-2	colony stimulating factor 3	Homo sapiens	374-379
1421314-1	1992	In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases.	Oxygen	90-96	5' nucleotidase, ecto	Mus musculus	169-183
1323727-0	1992	Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys: evidence against mediation by cAMP.	Oxygen	6-12	erythropoietin	Rattus norvegicus	34-48
1323727-1	1992	Erythropoietin (EPO) is mainly produced in the kidneys and is regulated by blood oxygen availability.	Oxygen	81-87	erythropoietin	Rattus norvegicus	0-14
1323727-1	1992	Erythropoietin (EPO) is mainly produced in the kidneys and is regulated by blood oxygen availability.	Oxygen	81-87	erythropoietin	Rattus norvegicus	16-19
1323727-3	1992	Using a quantitative RNase protection assay, we have demonstrated oxygen-dependent EPO mRNA production in isolated perfused rat kidneys, with EPO mRNA levels increasing 30-fold when perfusate pO2 was reduced from 474 to 25 mm Hg.	Oxygen	66-72	erythropoietin	Rattus norvegicus	83-86
1323727-3	1992	Using a quantitative RNase protection assay, we have demonstrated oxygen-dependent EPO mRNA production in isolated perfused rat kidneys, with EPO mRNA levels increasing 30-fold when perfusate pO2 was reduced from 474 to 25 mm Hg.	Oxygen	66-72	erythropoietin	Rattus norvegicus	142-145
1630626-3	1992	Half the rats exposed to low levels of oxygen in the presence of 8-cyclopentyltheophylline (10 mg/kg) suffered unilateral or bilateral hippocampal damage largely limited to the CA1 subfield.	Oxygen	39-45	carbonic anhydrase 1	Rattus norvegicus	177-180
1582274-15	1992	We conclude that in immunocompromised patients, bronchoscopy with BAL induces severe arterial oxygen desaturation which is correlated with initial PFT and chest roentgenographic findings, and most of these abnormalities are transient and do not lead to major complications.	Oxygen	94-100	poly(ADP-ribose) polymerase family member 9	Homo sapiens	66-69
1601790-8	1992	The O2 costs of hyperpnea correlated highly and positively with VE and WV and less, but significantly, with integral of Pdi.dt and integral of Pga.dt.	Oxygen	4-6	peptidyl arginine deiminase 1	Homo sapiens	120-123
1325688-12	1992	If glutamate 387 of rat brain sodium channel II were the anionic site which ion-pairs with the 7, 8, 9 guanidinium of STX, then the carbonyl oxygen of asparagin 388 is the hydrogen-acceptor for the C-12 gem-diols.	Oxygen	141-147	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	118-121
1313236-5	1992	In vitro, two modes of action of the DHO-DH are possible: (i) acting as a dehydrogenase in the presence of ubiquinone as proximal electron acceptor and (ii) direct reaction with oxygen as oxidase.	Oxygen	178-184	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	37-43
1633261-0	1992	D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance.	Oxygen	111-117	LIF interleukin 6 family cytokine	Homo sapiens	0-8
1633261-2	1992	In this study, we demonstrated that recombinant human D-factor and growth hormone caused a slight but significant protection of adult rats against oxygen toxicity without affecting levels of pulmonary manganous superoxide dismutase (MnSOD) mRNA.	Oxygen	147-153	LIF interleukin 6 family cytokine	Homo sapiens	54-62
1633261-3	1992	D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance.	Oxygen	87-93	LIF interleukin 6 family cytokine	Homo sapiens	0-8
1413124-3	1992	Temperature being decreased from 37 to 15 degrees C, myoglobin affinity to oxygen considerably increases.	Oxygen	75-81	myoglobin	Homo sapiens	53-62
7935843-1	1994	Myoglobin is a globular haem protein that reversibly binds ligands such as O2 and CO.	Oxygen	75-77	myoglobin	Homo sapiens	0-9
8086436-0	1994	Consequence of rapid heme rotation to the oxygen binding of myoglobin.	Oxygen	42-48	myoglobin	Homo sapiens	60-69
7913930-11	1994	AggR was found to promote expression of the aggA gene under a variety of conditions of temperature, osmolarity, oxygen tension, and medium.	Oxygen	112-118	transcriptional activator	Escherichia coli	0-4
8027554-7	1994	The allelic phenotype of Fc gamma RIIa strongly influences the Fc gamma receptor engagement by ligand, and Fc gamma RIIa homozygous donors differ by more than threefold in the quantitative production of reactive oxygen intermediates (ROI) (p &lt; 0.01).	Oxygen	212-218	Fc gamma receptor Ia	Homo sapiens	63-80
8034718-4	1994	Production of the immunoreactive Epo was dependent on O2 tension for cell culture; hypoxia enhanced the production.	Oxygen	54-56	erythropoietin	Rattus norvegicus	33-36
8034718-9	1994	Analyses with the reverse transcription-polymerase chain reaction method indicated that the regulation of Epo production by oxygen operates at the level of its mRNA.	Oxygen	124-130	erythropoietin	Rattus norvegicus	106-109
1310985-9	1992	An unexpected finding was that alanine 80 cytochrome c acquires a hemoglobin-like spectrum, and binds O2 most effectively.	Oxygen	102-104	cytochrome c, somatic	Equus caballus	42-54
8022811-0	1994	Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3" enhancer.	Oxygen	0-6	phosphoglycerate kinase 1	Homo sapiens	41-66
25293376-9	2014	Low oxygen supply upregulated CXCR4, CCR7 and CXCR6, but downregulated CXCL12 and CCR1.	Oxygen	4-10	C-X-C motif chemokine receptor 6	Homo sapiens	46-51
1540207-2	1992	When L-tyrosyl-glycyl-L-phenylalanyl-L-leucine (Leu-enkephalin) is exposed to the activated oxygen species produced by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs), hydroxylation of the phenylalanyl residue in position 4 of the peptide occurs, producing hydroxy-phenylalanyl derivatives which are identified by HPLC analysis and mass spectrometry.	Oxygen	92-98	prodynorphin	Homo sapiens	48-62
25406283-0	2014	CEACAM1 confers resistance toward oxygen-induced vessel damage in a mouse model of retinopathy of prematurity.	Oxygen	34-40	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	0-7
1537350-5	1992	In vitro incubation of neutrophils with recombinant human interferon-gamma (rIFN-gamma) showed an increase in oxygen consumption, but no effect on the expression of the LeuCAMs, or the beta chain mRNA.	Oxygen	110-116	interferon gamma	Rattus norvegicus	76-86
8200165-4	1994	We hypothesized that oxygen saturations of sick children at the University of Utah, Salt Lake City (1,500 meters above sea level), would be lower than oxygen saturations of those who were well.	Oxygen	21-27	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	119-122
8200165-8	1994	Mean oxygen saturation for well children (range 96% to 100%, mean 98.9%) corresponded to reported values at sea level.	Oxygen	5-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	108-111
25406283-1	2014	PURPOSE: To determine a functional role for the carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) in retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	166-172	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	48-105
7910235-3	1994	The error in arterial oxygen saturation (pSO2) exceeded 2 SD (&gt; 3%) in 25% subjects at 50 mm Hg which in an ancillary experiment was produced by 11 of 26 nurses fixing the sensor.	Oxygen	22-28	DNA cross-link repair 1A	Homo sapiens	41-45
25406283-1	2014	PURPOSE: To determine a functional role for the carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) in retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	166-172	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	107-114
1563558-8	1992	A decrease in vasodilatory autocoids, prostacyclin and EDRF may result from the endothelial cell damage induced by oxygen free radicals.	Oxygen	115-121	alpha hemoglobin stabilizing protein	Homo sapiens	55-59
25406283-10	2014	This is the first study demonstrating that CEACAM1 enhances vascular remodeling and tuft regression by increasing endothelial resistance to alterations in oxygen tension, thus accelerating vascular recovery after systemic hypoxia.	Oxygen	155-161	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	43-50
25261240-3	2014	GPx2 silencing caused accumulation of radical oxygen species, sensitization to H2O2-induced apoptosis, and strongly reduced clone- and metastasis-forming capacity.	Oxygen	46-52	glutathione peroxidase 2	Homo sapiens	0-4
1733278-1	1992	Confluent calf pulmonary artery endothelial monolayers exposed to 95% oxygen for 1, 2, or 3 days exhibit a time-dependent increase in adherence to substratum, which closely parallels changes in actin cytoarchitecture and the distribution of focal contact proteins vinculin and talin.	Oxygen	70-76	vinculin	Bos taurus	264-272
1733279-0	1992	Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium.	Oxygen	20-26	surfactant associated protein B	Mus musculus	30-50
8156634-4	1994	Mechanisms underlying endothelium-dependent effects of oxygen include the sensitivity of the nitric oxide/endothelium-derived relaxing factor (EDRF), hydrogen peroxide, and eicosanoid pathways.	Oxygen	55-61	alpha hemoglobin stabilizing protein	Homo sapiens	100-141
8156634-4	1994	Mechanisms underlying endothelium-dependent effects of oxygen include the sensitivity of the nitric oxide/endothelium-derived relaxing factor (EDRF), hydrogen peroxide, and eicosanoid pathways.	Oxygen	55-61	alpha hemoglobin stabilizing protein	Homo sapiens	143-147
8052525-5	1994	Addition of the antioxidant catalase (100 IU/ml) to the extracellular solution delayed the onset of these effects, suggesting that reactive-oxygen-intermediates take part in di-4-ANEPPS induced photodynamic damage.	Oxygen	140-146	catalase	Cavia porcellus	28-36
25418722-6	2014	Furthermore, our data show that even transient changes in O2 concentration can affect cell fate through HIF by regulating the activity of MYC, a regulator of LIN28/let-7 that is critical for fate decisions in the neural lineage.	Oxygen	58-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-141
8130222-3	1994	The spectrum of the first phase is comparable to that of oxygen binding to myoglobin, while the spectrum of the second phase appears to contain a contribution from a peroxy intermediate.	Oxygen	57-63	myoglobin	Homo sapiens	75-84
8145237-11	1994	The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.	Oxygen	267-273	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	52-58
1284690-0	1992	[Oxygen affinity and regeneration capacity of SAG-M and PAGGS-M stored erythrocytes].	Oxygen	1-7	S-antigen visual arrestin	Homo sapiens	46-49
1434093-0	1992	ANP decreases arterial oxygen partial pressure by increasing shunt flow in pulmonary circulation.	Oxygen	23-29	natriuretic peptide A	Canis lupus familiaris	0-3
25377223-2	2014	We previously designed and tested a vector using a hypoxia-responsive domain and a glial fibrillary acidic protein (GFAP) promoter to drive green fluorescent protein (GFP) expression in Muller cells in the murine model of oxygen-induced retinopathy (OIR).	Oxygen	222-228	glial fibrillary acidic protein	Mus musculus	83-114
1434093-1	1992	This study was designed to clarify the decreased arterial oxygen partial pressure (PaO2) mechanism induced by atrial natriuretic peptide (ANP) infusion.	Oxygen	58-64	natriuretic peptide A	Canis lupus familiaris	110-136
1434093-1	1992	This study was designed to clarify the decreased arterial oxygen partial pressure (PaO2) mechanism induced by atrial natriuretic peptide (ANP) infusion.	Oxygen	58-64	natriuretic peptide A	Canis lupus familiaris	138-141
1434093-4	1992	In this study ANP decreased PaO2 from 89.0 +/- 4.2 to 85.4 +/- 5.4 mmHg during 20% oxygen ventilation, and from 138.1 +/- 3.6 to 132.5 +/- 4.1 mmHg during 30% oxygen ventilation.	Oxygen	83-89	natriuretic peptide A	Canis lupus familiaris	14-17
1434093-4	1992	In this study ANP decreased PaO2 from 89.0 +/- 4.2 to 85.4 +/- 5.4 mmHg during 20% oxygen ventilation, and from 138.1 +/- 3.6 to 132.5 +/- 4.1 mmHg during 30% oxygen ventilation.	Oxygen	159-165	natriuretic peptide A	Canis lupus familiaris	14-17
1509157-8	1992	These changes in mitochondrial utilization of oxygen were partially reversed by including albumin in the respiration medium.	Oxygen	46-52	albumin	Canis lupus familiaris	90-97
1958383-3	1991	The TNF-mediated endothelial cytotoxicity was more pronounced under hyperoxia (95% O2 and 5% CO2) than under normoxia (95% air and 5% CO2).	Oxygen	83-85	tumor necrosis factor	Canis lupus familiaris	4-7
8125965-10	1994	This myoglobin-derived peroxyl radical species is responsible for the advent of lipid peroxidation as proposed in ischemia/reperfusion injury, as well as other reactions, as exemplified by the O2-dependent epoxidation of styrene.	Oxygen	193-195	myoglobin	Homo sapiens	5-14
8262226-10	1993	The data indicate that the carbonyl group of the formylated N-terminal Met-1 and probably the carboxyl group of the subunit III C-terminal Val-81 provide some of seven essential oxygen ligands normally required for defining a Ca(2+)-binding site in proteins.	Oxygen	178-184	granzyme M	Homo sapiens	71-76
8281918-8	1993	The conformation of ribose phosphate is such that O2" is at a distance of 0.31 nm from phosphorus, and opposite the P-OP3 bond which accepts a hydrogen bond from His92 N epsilon H+; we infer from a model building study that this bond is equivalent to the scissile P-O5" in a substrate GpN.	Oxygen	50-52	pyrin domain containing 5	Homo sapiens	116-121
1961720-1	1991	Erythropoietin, the major hormone controlling red-cell production, is regulated in part through oxygen-dependent changes in the rate of transcription of its gene.	Oxygen	96-102	erythropoietin	Mus musculus	0-14
25377223-2	2014	We previously designed and tested a vector using a hypoxia-responsive domain and a glial fibrillary acidic protein (GFAP) promoter to drive green fluorescent protein (GFP) expression in Muller cells in the murine model of oxygen-induced retinopathy (OIR).	Oxygen	222-228	glial fibrillary acidic protein	Mus musculus	116-120
24328910-5	2014	CRITICAL ISSUES: This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury.	Oxygen	272-274	thioredoxin	Homo sapiens	60-63
1953752-4	1991	As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen.	Oxygen	72-78	ceruloplasmin	Cricetulus griseus	31-44
1953752-4	1991	As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen.	Oxygen	72-78	ceruloplasmin	Cricetulus griseus	119-132
1953752-4	1991	As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen.	Oxygen	172-178	ceruloplasmin	Cricetulus griseus	31-44
1953752-4	1991	As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen.	Oxygen	172-178	ceruloplasmin	Cricetulus griseus	119-132
8118702-0	1993	Release of choline from rat brain under hypoxia: contribution from phospholipase A2 but not from phospholipase D. Moderate hypoxia induced in rats by inhalation of 10% oxygen led to an increase of the concentration of free choline in the brain and caused a large net-release of choline from the brain into the venous blood as determined by the measurement of the arterio-venous difference.	Oxygen	168-174	phospholipase A2 group IB	Rattus norvegicus	67-83
1953752-6	1991	The four electron transfer from ceruloplasmin to oxygen to form water will prevent peroxide formation at the cell surface.	Oxygen	49-55	ceruloplasmin	Cricetulus griseus	32-45
24328910-5	2014	CRITICAL ISSUES: This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury.	Oxygen	272-274	thioredoxin	Homo sapiens	157-160
8141810-1	1993	DNA single strand breaks were determined in peripheral lymphocytes of neurosurgical patients before and after 180 min of general anesthesia with isoflurane (CAS 26675-46-7)-nitrous oxide-oxygen.	Oxygen	187-193	BCAR1 scaffold protein, Cas family member	Homo sapiens	157-160
24328910-5	2014	CRITICAL ISSUES: This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury.	Oxygen	354-356	thioredoxin	Homo sapiens	60-63
8172573-3	1993	For example, the binding of C1q to monocytes enhances the ability of those cells to ingest pathogens, while interaction with neutrophils, eosinophils, endothelial cells and vascular smooth muscle cells triggers or enhances the generation of toxic oxygen species.	Oxygen	247-253	complement C1q A chain	Homo sapiens	28-31
24328910-5	2014	CRITICAL ISSUES: This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury.	Oxygen	354-356	thioredoxin	Homo sapiens	157-160
25064694-6	2014	Decrease in fractional oxygen concentration of just 0.9% was associated with phosphorylation of ERK1/2, but not Akt, which was essential for up-regulation of SUR2A.	Oxygen	23-29	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	158-163
1716591-4	1991	Our data indicate that following BMT, both recipients and their normal donors show GM-CSF- and G-CSF-induced increases in: 1) O2- production in response to fMet-Leu-Phe (fMLP), 2) killing of S. aureus, and 3) phagocytosis of C. albicans.	Oxygen	126-128	colony stimulating factor 2	Homo sapiens	83-89
1716591-4	1991	Our data indicate that following BMT, both recipients and their normal donors show GM-CSF- and G-CSF-induced increases in: 1) O2- production in response to fMet-Leu-Phe (fMLP), 2) killing of S. aureus, and 3) phagocytosis of C. albicans.	Oxygen	126-128	colony stimulating factor 3	Homo sapiens	95-100
1716591-6	1991	Our studies indicate that GM-CSF and G-CSF increase "oxygen-dependent" oxidative activities in neutrophils from BMT recipients and their normal donors and enhance the antimicrobial activity of the cells.	Oxygen	53-59	colony stimulating factor 2	Homo sapiens	26-32
25064694-7	2014	These findings indicate that a small drop in oxygen tension up-regulates SUR2A in the heart by activating ERK signaling pathway.	Oxygen	45-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	73-78
1716591-6	1991	Our studies indicate that GM-CSF and G-CSF increase "oxygen-dependent" oxidative activities in neutrophils from BMT recipients and their normal donors and enhance the antimicrobial activity of the cells.	Oxygen	53-59	colony stimulating factor 3	Homo sapiens	37-42
1960796-3	1991	Maximal oxygen uptake during treadmill running and double-poling was correlated with performance, expressed as a ranking score during 10 ski races.	Oxygen	8-14	SKI proto-oncogene	Homo sapiens	137-140
1960796-11	1991	The maximal oxygen uptake measured using the ski ergometer during double-poling was significantly correlated with performance (P less than 0.05).	Oxygen	12-18	SKI proto-oncogene	Homo sapiens	45-48
24977940-5	2014	Research during the last decade reveals that leptin is a truly pleiotropic hormone in fish and mammals alike, with functions among others in the regulation of food intake and body weight, development, but also in the regulation of the stress axis and acclimation processes to for instance low oxygen levels in the water.	Oxygen	293-299	leptin	Homo sapiens	45-51
1653522-2	1991	Ep levels in the medium of low density Hep 3B cells treated with CHA in concentrations of 10(-5) and 5 x 10(-5) M for 20 h under hypoxic conditions (1% O2) were significantly higher than that of hypoxic controls.	Oxygen	152-154	transcription factor like 5	Homo sapiens	65-68
1930739-3	1991	Recent investigations have demonstrated a potential role for hyperoxia and hyperbaric oxygen as therapeutic interventions for CCl4 poisoning.	Oxygen	86-92	C-C motif chemokine ligand 4	Homo sapiens	126-130
1930739-6	1991	Case reports of human poisoning, with potentially lethal ingested doses of CCl4, also suggest a potential role for treatment with hyperbaric oxygen.	Oxygen	141-147	C-C motif chemokine ligand 4	Homo sapiens	75-79
1930739-8	1991	These studies and case reports support the recommendation that 100% normobaric and hyperbaric oxygen should be treatment considerations for CCl4 poisoning.	Oxygen	94-100	C-C motif chemokine ligand 4	Homo sapiens	140-144
25275529-9	2014	Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1alpha, in association with increased frequency of FoxP3+ regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy.	Oxygen	218-224	indoleamine 2,3-dioxygenase 1	Mus musculus	23-26
1910315-4	1991	Co2+ inhibited microsomal NADPH-supported lipid peroxidation monitored in terms of malondialdehyde production and the peroxidation monitored in terms of oxygen consumption.	Oxygen	153-159	complement C2	Homo sapiens	0-3
25275529-9	2014	Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1alpha, in association with increased frequency of FoxP3+ regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy.	Oxygen	218-224	forkhead box P3	Mus musculus	124-129
25018004-12	2014	In O2-saturated apoferritin solutions, Q, O2-, AA and reaction product(s) react with QH.	Oxygen	3-5	ferritin heavy chain 1	Homo sapiens	16-27
1651729-1	1991	NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein which catalyzes the two-electron reduction of quinones and azo-dyes and thus prevents the formation of free radicals and toxic oxygen metabolites that may be generated by the one-electron reductions catalyzed by cytochrome P450 reductase.	Oxygen	183-189	crystallin zeta	Homo sapiens	8-30
25018004-12	2014	In O2-saturated apoferritin solutions, Q, O2-, AA and reaction product(s) react with QH.	Oxygen	42-44	ferritin heavy chain 1	Homo sapiens	16-27
1918521-1	1991	The strong calcium-binding site of alpha-lactalbumin comprises the carboxylate side chains of aspartic acid 82, 87, and 88 and the carbonyl oxygens of residues 79 and 84.	Oxygen	140-147	lactalbumin alpha	Bos taurus	35-52
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	glutamate ionotropic receptor NMDA type subunit 2B	Sus scrofa	45-51
25106706-7	2014	Increased cell death was observed during oxygen exposure when either the Trx or the glutathione-dependent system was pharmacologically inhibited with aurothioglucose (ATG) or buthionine sulfoximine, respectively.	Oxygen	41-47	thioredoxin	Homo sapiens	73-76
1858930-1	1991	Inactivation of intracellular myoglobin by sodium nitrite or by carbon monoxide in isolated cardiac myocytes diminishes steady-state respiratory rate and phosphocreatine concentration (PCr) by approximately 25% at nonlimiting oxygen pressures; oxidative phosphorylation and glycolysis together are insufficient to maintain ATP, and PCr falls.	Oxygen	226-232	myoglobin	Homo sapiens	30-39
24875598-6	2014	Furthermore, these inhibitors effectively suppressed expression of target genes of HIF-1alpha including vegfa in the retina of oxygen-induced retinopathy (OIR) mice.	Oxygen	127-133	hypoxia inducible factor 1, alpha subunit	Mus musculus	83-93
1858930-5	1991	However, inhibition of electron transport by rotenone does block myoglobin-mediated oxygen uptake.	Oxygen	84-90	myoglobin	Homo sapiens	65-74
1858930-8	1991	At high oxygen pressures used here, myoglobin is everywhere saturated with oxygen, and facilitated oxygen diffusion vanishes.	Oxygen	8-14	myoglobin	Homo sapiens	36-45
1858930-8	1991	At high oxygen pressures used here, myoglobin is everywhere saturated with oxygen, and facilitated oxygen diffusion vanishes.	Oxygen	75-81	myoglobin	Homo sapiens	36-45
1858930-8	1991	At high oxygen pressures used here, myoglobin is everywhere saturated with oxygen, and facilitated oxygen diffusion vanishes.	Oxygen	75-81	myoglobin	Homo sapiens	36-45
24939362-8	2014	Microarray analysis shows that there is significant decrease in the abundance of Cdks 6-8 and retinoblastoma protein (Rb), p107 and p130 in exposure to 90 % oxygen for 48 h. We further tested the effect of clinically relevant as needed oxygen [(pro-re-nata (prn)] in premature infant (125-days and 140-days) baboon model of BPD.	Oxygen	157-163	cyclin-dependent kinase 6	Papio anubis	81-89
1649598-1	1991	Treatment of human beta 2 microglobulin (beta 2m) with defined oxygen-derived species generated by treatment with gamma-radiation was studied.	Oxygen	63-69	beta-2-microglobulin	Homo sapiens	19-39
1649598-1	1991	Treatment of human beta 2 microglobulin (beta 2m) with defined oxygen-derived species generated by treatment with gamma-radiation was studied.	Oxygen	63-69	beta-2-microglobulin	Homo sapiens	41-48
1649598-4	1991	Exposure to .OH alone, or to .OH + O2.- in the presence of O2, induced the formation of beta 2m protein derivatives with a more acidic net electrical charge than the parent molecule.	Oxygen	35-37	beta-2-microglobulin	Homo sapiens	88-95
1649598-4	1991	Exposure to .OH alone, or to .OH + O2.- in the presence of O2, induced the formation of beta 2m protein derivatives with a more acidic net electrical charge than the parent molecule.	Oxygen	59-61	beta-2-microglobulin	Homo sapiens	88-95
25096497-1	2014	Paradoxical reduction of cerebral blood flow (CBF) after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction (OEF).	Oxygen	210-216	core-binding factor subunit beta	Homo sapiens	46-49
25044690-8	2014	Reduced O2 consumption, increased adiposity, and fewer POMC neurons observed in CN-FoxO1 mice were rescued in male DKI mice without affecting food intake and locomotor activity.	Oxygen	8-10	forkhead box O1	Mus musculus	83-88
1862226-0	1991	Effect of ambient oxygen changes on platelet activating factor production by fetal ovine endothelial cells.	Oxygen	18-24	PCNA clamp associated factor	Homo sapiens	36-62
25271810-2	2014	HIF-2alpha was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX2 only in hESCs cultured under hypoxia (5% O2).	Oxygen	174-176	endothelial PAS domain protein 1	Homo sapiens	0-10
1899817-2	1991	We therefore determined changes in PVR during oxygen therapy in two patient populations not previously studied: systemic sclerosis (n = 8, mean age +/- SEM, 44.5 +/- 5.4 years) and primary pulmonary hypertension (n = 7, mean age +/- SEM 38 +/- 7.8 years).	Oxygen	46-52	PVR cell adhesion molecule	Homo sapiens	35-38
1899817-5	1991	The PVR fell significantly with oxygen in patients with SSc from 797.6 +/- 179.2 to 610 +/- 151.6 dynes/s/cm-5 (p less than 0.01), and this fall correlated with baseline PAP and PaO2 prior to oxygen therapy (r = 0.86, p less than 0.025; r = 0.77, p less than 0.05, respectively).	Oxygen	32-38	PVR cell adhesion molecule	Homo sapiens	4-7
1899817-5	1991	The PVR fell significantly with oxygen in patients with SSc from 797.6 +/- 179.2 to 610 +/- 151.6 dynes/s/cm-5 (p less than 0.01), and this fall correlated with baseline PAP and PaO2 prior to oxygen therapy (r = 0.86, p less than 0.025; r = 0.77, p less than 0.05, respectively).	Oxygen	192-198	PVR cell adhesion molecule	Homo sapiens	4-7
2036470-5	1991	Additionally, dexamethasone sensitized the neonatal brain to hypoxia: the acute increase of ODC associated with a 2-h exposure to 7% O2 was exacerbated in 8-day-old rats exposed to dexamethasone prenatally.	Oxygen	133-135	ornithine decarboxylase 1	Rattus norvegicus	92-95
2044536-7	1991	The O2 cost per WR increment (delta VO2/delta WR) in ml.min-1.w-1, measured during the incremental period (mean 10.9; range 8.3-12.2), was always within two standard deviations of the normal value (10.3, SD 1).	Oxygen	4-6	CUP2Q35	Homo sapiens	204-208
25271810-2	2014	HIF-2alpha was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX2 only in hESCs cultured under hypoxia (5% O2).	Oxygen	174-176	POU class 5 homeobox 1	Homo sapiens	112-116
2085744-5	1990	The survival of microtubule-associated protein 2 (MAP2)-positive neurons in culture from P3 basal forebrain regions was more enhanced in a 50% O2 atmosphere than in 20% and also 10% O2 atmosphere.	Oxygen	143-145	microtubule-associated protein 2	Rattus norvegicus	50-54
2085744-5	1990	The survival of microtubule-associated protein 2 (MAP2)-positive neurons in culture from P3 basal forebrain regions was more enhanced in a 50% O2 atmosphere than in 20% and also 10% O2 atmosphere.	Oxygen	182-184	microtubule-associated protein 2	Rattus norvegicus	16-48
25172328-8	2014	Further studies must elucidate the novel functional roles of MB in human carcinomas, which probably extend beyond its classic intramuscular function in oxygen storage.	Oxygen	152-158	myoglobin	Homo sapiens	61-63
2085744-5	1990	The survival of microtubule-associated protein 2 (MAP2)-positive neurons in culture from P3 basal forebrain regions was more enhanced in a 50% O2 atmosphere than in 20% and also 10% O2 atmosphere.	Oxygen	182-184	microtubule-associated protein 2	Rattus norvegicus	50-54
2085744-6	1990	The viable number of the MAP2-positive neurons in a 10% O2 condition was about half of that in a 20% condition.	Oxygen	56-58	microtubule-associated protein 2	Rattus norvegicus	25-29
2260684-2	1990	Because erythropoietin production has been localized mainly to the renal cortex, the aim of this study was to find a common denominator for both the high susceptibility to hypoxia and oxygen sensing within the renal cortex.	Oxygen	184-190	erythropoietin	Rattus norvegicus	8-22
24605822-6	2014	Hydrogen bonding of the side-chain hydroxyl group with a backbone carbonyl oxygen aligns the singly occupied pi orbital on the beta-carbon and the N-Calpha bond, leading to low-barrier beta-cleavage of the N-Calpha bond.	Oxygen	75-81	CEA cell adhesion molecule 6	Homo sapiens	147-155
2253718-6	1990	Recent experiments demonstrate that the release of EDRF is PO2-dependent, which suggests that endothelial cells may act as functional local oxygen sensors within the vascular system.	Oxygen	140-146	alpha hemoglobin stabilizing protein	Homo sapiens	51-55
2253723-1	1990	The glycoprotein hormone erythropoietin (EPO) counteracts tissue hypoxia by increasing the systemic oxygen-carrying capacity.	Oxygen	100-106	erythropoietin	Rattus norvegicus	25-39
2253723-1	1990	The glycoprotein hormone erythropoietin (EPO) counteracts tissue hypoxia by increasing the systemic oxygen-carrying capacity.	Oxygen	100-106	erythropoietin	Rattus norvegicus	41-44
2253723-3	1990	EPO production is increased under various forms of diminished oxygen supply such as anemic or hypoxic hypoxia.	Oxygen	62-68	erythropoietin	Rattus norvegicus	0-3
2253723-7	1990	From the observation that isolated perfused rat kidneys produce EPO in an oxygen-dependent fashion we conclude that the "oxygen sensor" that controls hypoxia-induced EPO synthesis is located in the kidney itself.	Oxygen	74-80	erythropoietin	Rattus norvegicus	64-67
8248932-5	1993	A progressive reduction in brain microvessel MPO titers occurred with exposure to O2 at 1, 2, or 3 ATA after CO poisoning, but 1 ATA O2 treatment did not significantly inhibit xanthine oxidase formation or lipid peroxidation.	Oxygen	82-84	myeloperoxidase	Rattus norvegicus	45-48
2253723-7	1990	From the observation that isolated perfused rat kidneys produce EPO in an oxygen-dependent fashion we conclude that the "oxygen sensor" that controls hypoxia-induced EPO synthesis is located in the kidney itself.	Oxygen	74-80	erythropoietin	Rattus norvegicus	166-169
24605822-6	2014	Hydrogen bonding of the side-chain hydroxyl group with a backbone carbonyl oxygen aligns the singly occupied pi orbital on the beta-carbon and the N-Calpha bond, leading to low-barrier beta-cleavage of the N-Calpha bond.	Oxygen	75-81	CEA cell adhesion molecule 6	Homo sapiens	206-214
2253723-7	1990	From the observation that isolated perfused rat kidneys produce EPO in an oxygen-dependent fashion we conclude that the "oxygen sensor" that controls hypoxia-induced EPO synthesis is located in the kidney itself.	Oxygen	121-127	erythropoietin	Rattus norvegicus	64-67
2253723-7	1990	From the observation that isolated perfused rat kidneys produce EPO in an oxygen-dependent fashion we conclude that the "oxygen sensor" that controls hypoxia-induced EPO synthesis is located in the kidney itself.	Oxygen	121-127	erythropoietin	Rattus norvegicus	166-169
8306425-7	1993	In response to 10.5% O2, in the 3-day-old rat, ODC activity peaked between 2 and 3 h of hypoxia, increasing 3-fold in the hippocampus and 2-fold in cerebellum.	Oxygen	21-23	ornithine decarboxylase 1	Rattus norvegicus	47-50
8306425-9	1993	In inspired oxygen dose-response studies, exposure of P 3 rat pups to 13.25% O2 for 2.5 h produced a 1.5-fold increase in ODC activity; 10.5% O2 produced a 2-3-fold increase while in response to 9% O2, ODC activity remained at baseline levels.	Oxygen	77-79	ornithine decarboxylase 1	Rattus norvegicus	122-125
2253723-8	1990	Within the kidneys, the local venous oxygen tension which reflects the ratio of oxygen supply to oxygen consumption is measured and transformed into a signal that regulates the formation of EPO.	Oxygen	37-43	erythropoietin	Rattus norvegicus	190-193
24236637-4	2014	Here, we demonstrate that the oxygen-sensitive hypoxia-inducible transcription factor, Hif-1alpha, is an essential regulator for neural commitment of ES cells.	Oxygen	30-36	hypoxia inducible factor 1, alpha subunit	Mus musculus	87-97
2253723-8	1990	Within the kidneys, the local venous oxygen tension which reflects the ratio of oxygen supply to oxygen consumption is measured and transformed into a signal that regulates the formation of EPO.	Oxygen	80-86	erythropoietin	Rattus norvegicus	190-193
2253723-8	1990	Within the kidneys, the local venous oxygen tension which reflects the ratio of oxygen supply to oxygen consumption is measured and transformed into a signal that regulates the formation of EPO.	Oxygen	80-86	erythropoietin	Rattus norvegicus	190-193
2253723-9	1990	However, the mechanism by which a decrease of oxygen delivery to the kidneys is linked to an enhanced EPO gene expression is not yet known.	Oxygen	46-52	erythropoietin	Rattus norvegicus	102-105
2253723-11	1990	Second, some kind of molecular "oxygen receptor" such as a heme protein, that controls EPO formation by an oxygen-dependent conformational change, could mediate signal transduction.	Oxygen	32-38	erythropoietin	Rattus norvegicus	87-90
2123827-1	1990	The Pan 1 protein of Neisseria gonorrhoeae is a novel 54-kDa outer membrane protein expressed only when gonococci are grown in the absence of oxygen.	Oxygen	142-148	pancreas protein 1	Mus musculus	4-9
8306425-9	1993	In inspired oxygen dose-response studies, exposure of P 3 rat pups to 13.25% O2 for 2.5 h produced a 1.5-fold increase in ODC activity; 10.5% O2 produced a 2-3-fold increase while in response to 9% O2, ODC activity remained at baseline levels.	Oxygen	77-79	ornithine decarboxylase 1	Rattus norvegicus	202-205
8229202-1	1993	Five minutes of oxygen and glucose deprivation (termed "in vitro ischemia") causes long-term synaptic transmission failure (LTF) in the CA1 region of the rat hippocampal slice.	Oxygen	16-22	carbonic anhydrase 1	Rattus norvegicus	136-139
10007224-0	1993	Oxygen intercalation and intergranular coupling in the 110-K Bi1.7Pb0.3Sr1.8Ca2Cu2.8O9.45+ delta superconductor.	Oxygen	0-6	transmembrane BAX inhibitor motif containing 6	Homo sapiens	61-64
2268551-3	1990	Three major factors are implicated in the ability of the steroid to bind to the membrane sites: (1) the separation between the terminal oxygen atoms substituted at atoms C3 and C17, or attached to the substituent at C17, is found to be longer than 10 A for the medium and high affinity steroids; (2) the beta-orientation of the oxygen atom in the C17-substituent to the D-ring is favored over alpha-orientation; and (3) bulky substituents and nontypical configurations are not accepted by the binding sites.	Oxygen	328-334	cytokine like 1	Homo sapiens	177-180
24673633-5	2014	SOD3, an Nrf2-independent antioxidant, was significantly reduced in the O2-exposed mice compared with RA.	Oxygen	72-74	superoxide dismutase 3, extracellular	Mus musculus	0-4
2292285-3	1990	The ventilatory response was evaluated from minute ventilation (VE) and mouth occlusion pressure (P0.2) slopes on arterial oxygen saturation (SaO2) or on end-tidal PCO2 (PACO2), and from absolute VE values at SaO2 80% or at PACO2 55 mmHg.	Oxygen	123-129	tumor protein, translationally-controlled 1	Homo sapiens	98-102
8314769-5	1993	The two genes are regulated reciprocally by oxygen, where under aerobic conditions TIF51A is expressed and TIF51B is repressed, and under anaerobic conditions the opposite occurs.	Oxygen	44-50	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	83-89
8349109-1	1993	The enzyme catalase protects aerobic organisms from oxygen-free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Oxygen	52-58	Catalase	Drosophila melanogaster	11-19
24673633-6	2014	Immunohistochemistry revealed decreased and disrupted SOD3 deposition in the alveolar ECM of O2-exposed mice.	Oxygen	93-95	superoxide dismutase 3, extracellular	Mus musculus	54-58
8349109-1	1993	The enzyme catalase protects aerobic organisms from oxygen-free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical.	Oxygen	124-130	Catalase	Drosophila melanogaster	11-19
25047150-6	2014	Circulating leptin levels were significantly and positively correlated with body weight, body mass index, abdominal circumference, insulin and the homeostasis model assessment index, and significantly and negatively correlated with peak oxygen uptake in both sexes.	Oxygen	237-243	leptin	Homo sapiens	12-18
8378428-3	1993	The photodynamic cell killing ability of CDS1 required the presence of molecular oxygen.	Oxygen	81-87	CDP-diacylglycerol synthase 1	Homo sapiens	41-45
8378428-11	1993	Based on these results, we conclude that CDS1 requires the presence of molecular oxygen for cell killing to occur but appears to act primarily through a non-singlet oxygen mechanism.	Oxygen	81-87	CDP-diacylglycerol synthase 1	Homo sapiens	41-45
8378428-11	1993	Based on these results, we conclude that CDS1 requires the presence of molecular oxygen for cell killing to occur but appears to act primarily through a non-singlet oxygen mechanism.	Oxygen	165-171	CDP-diacylglycerol synthase 1	Homo sapiens	41-45
2373996-0	1990	Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection.	Oxygen	0-6	erythropoietin	Rattus norvegicus	31-45
2373996-2	1990	The assay, which has sufficient sensitivity to measure to Epo mRNA in unstimulated rat kidneys, was used to demonstrate high amplitude in vitro modulation of Epo mRNA levels in response to changes in perfusate flow rate and oxygen tension in isolated kidneys, thus providing clear evidence that all the necessary events linking changes in oxygen delivery to the modulation of Epo mRNA levels can occur intrarenally.	Oxygen	224-230	erythropoietin	Rattus norvegicus	158-161
2373996-2	1990	The assay, which has sufficient sensitivity to measure to Epo mRNA in unstimulated rat kidneys, was used to demonstrate high amplitude in vitro modulation of Epo mRNA levels in response to changes in perfusate flow rate and oxygen tension in isolated kidneys, thus providing clear evidence that all the necessary events linking changes in oxygen delivery to the modulation of Epo mRNA levels can occur intrarenally.	Oxygen	224-230	erythropoietin	Rattus norvegicus	158-161
2373996-2	1990	The assay, which has sufficient sensitivity to measure to Epo mRNA in unstimulated rat kidneys, was used to demonstrate high amplitude in vitro modulation of Epo mRNA levels in response to changes in perfusate flow rate and oxygen tension in isolated kidneys, thus providing clear evidence that all the necessary events linking changes in oxygen delivery to the modulation of Epo mRNA levels can occur intrarenally.	Oxygen	339-345	erythropoietin	Rattus norvegicus	158-161
2373996-2	1990	The assay, which has sufficient sensitivity to measure to Epo mRNA in unstimulated rat kidneys, was used to demonstrate high amplitude in vitro modulation of Epo mRNA levels in response to changes in perfusate flow rate and oxygen tension in isolated kidneys, thus providing clear evidence that all the necessary events linking changes in oxygen delivery to the modulation of Epo mRNA levels can occur intrarenally.	Oxygen	339-345	erythropoietin	Rattus norvegicus	158-161
24958105-4	2014	Gabpalpha loss modestly reduced mitochondrial mass, ATP production, oxygen consumption, and mitochondrial protein synthesis but did not alter mitochondrial morphology, membrane potential, apoptosis, or the expression of several genes that were previously reported to be GABP targets.	Oxygen	68-74	GA repeat binding protein, alpha	Mus musculus	0-9
2134465-0	1990	Parameter dependence of myoglobin-facilitated transport of oxygen in the presence of membranes.	Oxygen	59-65	myoglobin	Homo sapiens	24-33
2134465-1	1990	Some physicochemical entities involved in the facilitated transport of oxygen along a transport path z1 less than or equal to z less than or equal to zn with membranes impermeable to myoglobin at zi, i = 1,...,n, were identified in an earlier paper [Math.	Oxygen	71-77	myoglobin	Homo sapiens	183-192
8358552-0	1993	Roles of prostacyclin, EDRF and active oxygens in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro.	Oxygen	39-46	PCNA clamp associated factor	Homo sapiens	120-146
8098618-10	1993	In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.	Oxygen	105-111	CD2 molecule	Homo sapiens	13-16
8469926-7	1993	The rIFN-gamma-activated macrophages displayed enhanced O2-consumption after stimulation with phorbol myristate acetate and heat-killed Listeria compared with macrophages from normal mice.	Oxygen	56-58	interferon gamma	Rattus norvegicus	4-14
2134465-8	1990	For a physiological range of parameter values, the facilitated transport was found to increase as either the oxygen-myoglobin association rate constant k", the dissociation rate constant k, the oxygen diffusion coefficient, or the oxymyoglobin diffusion coefficient increases.	Oxygen	109-115	myoglobin	Homo sapiens	116-125
2140252-6	1990	Discontinuation of O2 while decreasing PaO2 from 70 +/- 3 to 50 +/- 3 mm Hg resulted in a significant increase in pulmonary arterial pressure (Ppa) from 29 +/- 2 to 32.5 +/- 3 mm Hg (p less than 0.01) and cardiac index (Cl) from 3.6 +/- 0.1 to 3.9 +/- 0.1 L/min/m2 (p less than 0.01) and a decrease in systemic arterial pressure (Psa) from 96 +/- 3 to 91 +/- 2 mm Hg (p less than 0.05); transmural cardiac filling pressures and pulmonary vascular resistance (PVR) were unchanged.	Oxygen	19-21	aminopeptidase puromycin sensitive	Homo sapiens	330-333
25008783-5	2014	Interestingly, the BGE and DE from oxygen vacancies of ZnO in the ZnO/CdS nano-composites are almost entirely quenched, while DE from zinc vacancies changes little.	Oxygen	35-41	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
2131832-4	1990	On the basis of these findings, an integrated metabolic scheme is proposed which invokes initial cytochrome P-450 mediated generation of a caged oxygen-centered APAP radical species.	Oxygen	145-151	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	97-113
2156842-1	1990	A relatively pure and stable compound III of bovine spleen myeloperoxidase was prepared from native enzyme using the aerobic oxidation of dihydroxyfumarate to generate O2-(.).	Oxygen	168-170	myeloperoxidase	Bos taurus	59-74
8458333-1	1993	Previously, it was shown that the CYP1(HAP1) gene product mediates the transcription of several oxygen-regulated genes through a metabolic co-effector, heme, in the yeast Saccharomyces cerevisiae.	Oxygen	96-102	Hap1p	Saccharomyces cerevisiae S288C	34-38
8458333-1	1993	Previously, it was shown that the CYP1(HAP1) gene product mediates the transcription of several oxygen-regulated genes through a metabolic co-effector, heme, in the yeast Saccharomyces cerevisiae.	Oxygen	96-102	Hap1p	Saccharomyces cerevisiae S288C	39-43
24965795-6	2014	As a consequence, constitutively reduced myostatin signaling diminishes exercise capacity, while the hypermuscular state of Mstn(-/-) mice increases oxygen consumption and the energy cost of running.	Oxygen	149-155	myostatin	Mus musculus	124-128
8440599-1	1993	PURPOSE: The goal of this study was to evaluate the effect of oxygen deprivation on rhodopsin regeneration in the excised mouse eye.	Oxygen	62-68	rhodopsin	Mus musculus	84-93
8440599-9	1993	CONCLUSIONS: Low levels of oxygen eliminated rhodopsin regeneration in the excised eye.	Oxygen	27-33	rhodopsin	Mus musculus	45-54
2312718-2	1990	We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects seen when bones are treated with hormones such as parathyroid hormone (PTH) and interleukin 1 (IL-1).	Oxygen	36-42	interleukin 1 alpha	Homo sapiens	269-288
25046356-1	2014	Adsorption of H2O and CO2 on zinc oxide surfaces was studied by gas adsorption calorimetry on nanocrystalline samples prepared by laser evaporation in oxygen to minimize surface impurities and degassed at 450  C. Differential enthalpies of H2O and CO2 chemisorption are in the range -150 +-10 kJ/mol and -110 +-10 kJ/mol up to a coverage of 2 molecules per nm(2).	Oxygen	151-157	complement C2	Homo sapiens	14-25
1965086-0	1990	Factors affecting oxygen-induced changes in the activity of CTP-dependent lipid kinases in yeast.	Oxygen	18-24	solute carrier family 25 member 1	Homo sapiens	60-63
1482049-4	1992	For example, active oxygen activates protein kinases, causes DNA breakage, and induces the growth competence-related protooncogenes c-fos and c-myc.	Oxygen	20-26	FBJ osteosarcoma oncogene	Mus musculus	132-137
1445857-14	1992	Extremely high oxygen affinities were found for the triply-ligated species (alpha +CN beta +CN)(alpha beta +CN) and (alpha +CN beta +CN)(alpha +CN beta) (pmedian = 0.2 Torr).	Oxygen	15-21	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	124-131
25010511-1	2014	Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines.	Oxygen	191-197	ATM serine/threonine kinase	Homo sapiens	184-187
1445857-14	1992	Extremely high oxygen affinities were found for the triply-ligated species (alpha +CN beta +CN)(alpha beta +CN) and (alpha +CN beta +CN)(alpha +CN beta) (pmedian = 0.2 Torr).	Oxygen	15-21	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	124-131
1445857-16	1992	Oxygen binding free energies measured for the alpha subunit within the isolated (alpha beta +CN) dimer and for the beta subunit within the isolated (alpha +CN beta) dimer sum to the free energy for binding two oxygens to normal hemoglobin dimers (-16.3 +/- 0.2 versus -16.7 +/- 0.2, respectively), arguing against cooperativity in the isolated dimer.	Oxygen	0-6	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	156-163
1445857-16	1992	Oxygen binding free energies measured for the alpha subunit within the isolated (alpha beta +CN) dimer and for the beta subunit within the isolated (alpha +CN beta) dimer sum to the free energy for binding two oxygens to normal hemoglobin dimers (-16.3 +/- 0.2 versus -16.7 +/- 0.2, respectively), arguing against cooperativity in the isolated dimer.	Oxygen	210-217	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	156-163
2386516-1	1990	In order to further investigate the dependency of the production of erythropoietin (Epo) on the renal O2 supply, experiments were carried out in the isolated perfused rat kidney (IPRK).	Oxygen	102-104	erythropoietin	Rattus norvegicus	68-82
2386516-1	1990	In order to further investigate the dependency of the production of erythropoietin (Epo) on the renal O2 supply, experiments were carried out in the isolated perfused rat kidney (IPRK).	Oxygen	102-104	erythropoietin	Rattus norvegicus	84-87
25010511-2	2014	The addition of hydrogen peroxide (30% aq) as a co-oxidant in the system is crucial for the dehydrogenative aminohalogenation under molecular oxygen (1 atm), and in such a case, the C-N bond coupling/electrophilic bromination reaction cascade is proposed.	Oxygen	142-148	ATM serine/threonine kinase	Homo sapiens	152-155
2330729-8	1990	The approximated validity of computed parameters is explained by the way of the examples oxygen saturation (O2sat) and oxygen concentration (cO2).	Oxygen	119-125	complement C2	Homo sapiens	141-144
1409612-4	1992	IL-1ra blocked the increased body temperature and oxygen consumption induced by injection of recombinant human IL-1 only when both cytokines were administered i.p.	Oxygen	50-56	interleukin 1 receptor antagonist	Homo sapiens	0-6
25081069-10	2014	Our results revealed that miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration.	Oxygen	87-93	microRNA 769	Homo sapiens	26-33
1409612-4	1992	IL-1ra blocked the increased body temperature and oxygen consumption induced by injection of recombinant human IL-1 only when both cytokines were administered i.p.	Oxygen	50-56	interleukin 1 alpha	Homo sapiens	0-4
24824450-3	2014	ARNT is also required by the hypoxia-inducible factor-1alpha (HIF-1alpha), a crucial regulator of responses to conditions of reduced oxygen.	Oxygen	133-139	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
1415576-6	1992	However, the hypoxia-induced increases in EPO mRNA in brain, testis, and spleen suggest the existence of an oxygen-sensing mechanism at other sites.	Oxygen	108-114	erythropoietin	Rattus norvegicus	42-45
1415591-8	1992	These results suggest that diabetic rat aortas release similar levels of EDRF in response to acetylcholine, but the action of EDRF arising from diabetic donors is attenuated by enhanced release of oxygen-derived free radicals, which limits EDRF-mediated relaxation of vascular smooth muscle.	Oxygen	197-203	alpha hemoglobin stabilizing protein	Homo sapiens	126-130
1415591-8	1992	These results suggest that diabetic rat aortas release similar levels of EDRF in response to acetylcholine, but the action of EDRF arising from diabetic donors is attenuated by enhanced release of oxygen-derived free radicals, which limits EDRF-mediated relaxation of vascular smooth muscle.	Oxygen	197-203	alpha hemoglobin stabilizing protein	Homo sapiens	126-130
1305089-0	1992	[Effect of ceruloplasmin on the oxygen tension in muscular tissue of experimental animals].	Oxygen	32-38	ceruloplasmin	Mus musculus	11-24
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	116-122	ceruloplasmin	Mus musculus	90-103
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	116-122	ceruloplasmin	Mus musculus	105-107
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	138-144	ceruloplasmin	Mus musculus	90-103
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	138-144	ceruloplasmin	Mus musculus	105-107
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	138-144	ceruloplasmin	Mus musculus	90-103
1305089-1	1992	The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr.	Oxygen	138-144	ceruloplasmin	Mus musculus	105-107
1305089-2	1992	It has been shown that CP in AKR mice improves oxygen saturation of the muscular tissue.	Oxygen	47-53	ceruloplasmin	Mus musculus	23-25
3157688-6	1985	Purified myosin is also found to show a small additional increase in ATPase rate at much higher ATP levels with a corresponding increase in flux through a pathway with a low extent of oxygen exchange.	Oxygen	184-190	myosin heavy chain 14	Homo sapiens	9-15
33970624-1	2021	Using UV-vis and resonance Raman spectroscopy, we identify a [Cu2O]2+ active site in O2 and N2O activated Cu-CHA that reacts with methane to form methanol at low temperature.	Oxygen	85-87	transcription factor like 5	Homo sapiens	109-112
33972668-4	2021	Mechanistically, MFN2 was required for the enhancement of inflammatory signaling through optimal induction of aerobic glycolysis via HIF-1alpha, which is activated by mitochondrial respiratory chain complex I and reactive oxygen species, in macrophages.	Oxygen	222-228	hypoxia inducible factor 1, alpha subunit	Mus musculus	133-143
33971209-4	2021	We suggest that, by preventing the direct ET to molecular oxygen (O2), the collision-type Cc-Erv1 interaction plays a role in protecting the organism against reactive oxygen species.	Oxygen	58-64	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	93-97
33971209-4	2021	We suggest that, by preventing the direct ET to molecular oxygen (O2), the collision-type Cc-Erv1 interaction plays a role in protecting the organism against reactive oxygen species.	Oxygen	66-68	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	93-97
33971209-4	2021	We suggest that, by preventing the direct ET to molecular oxygen (O2), the collision-type Cc-Erv1 interaction plays a role in protecting the organism against reactive oxygen species.	Oxygen	167-173	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	93-97
24838754-0	2014	TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.	Oxygen	88-94	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
33941651-5	2021	It was also found that ERbeta agonist administration in peri-AOF females, but not males, suppressed the heightened NMDA receptor signaling and reactive oxygen production in ERbeta neurons in the hypothalamic paraventricular nucleus (PVN), a critical neural regulator of blood pressure.	Oxygen	152-158	estrogen receptor 1 (alpha)	Mus musculus	23-29
33941651-5	2021	It was also found that ERbeta agonist administration in peri-AOF females, but not males, suppressed the heightened NMDA receptor signaling and reactive oxygen production in ERbeta neurons in the hypothalamic paraventricular nucleus (PVN), a critical neural regulator of blood pressure.	Oxygen	152-158	estrogen receptor 1 (alpha)	Mus musculus	173-179
1420896-0	1992	Hydrogen peroxide plays a key role in the oxidation reaction of myoglobin by molecular oxygen.	Oxygen	87-93	myoglobin	Homo sapiens	64-73
1420896-8	1992	Such examinations with the aid of a computer provide us, for the first time, with a full picture of the oxidation reaction of myoglobin as a function of oxygen pressures.	Oxygen	153-159	myoglobin	Homo sapiens	126-135
1627798-7	1992	In suspension cultures, reduced oxygen increased cumulative total cell production by 125% and 167%, and cumulative progenitor production by 68% and 21%, with IL-1/IL-3 and IL-3/IL-6, respectively.	Oxygen	32-38	interleukin 3	Homo sapiens	158-167
24838754-6	2014	TRPV4 inhibitors had similar anti-inflammatory effects in chlorine-exposed mice and inhibited vascular leakage, airway hyperreactivity, and increase in elastance, while improving blood oxygen saturation.	Oxygen	185-191	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
25347858-5	2014	Here, we sought to determine the role played by oxygen tension on the derivation of Nkx2.1+ lung/thyroid progenitor cells from mouse ESC and iPSC.	Oxygen	48-54	NK2 homeobox 1	Mus musculus	84-90
1610817-3	1992	The guanidinium NH2 nitrogen of Arg 44 forms one hydrogen bond to the imide nitrogen and a second to the carbonyl oxygen of Pro 66 in wild-type DHFR.	Oxygen	114-120	Dihydrofolate reductase	Escherichia coli	144-148
33820487-5	2021	Also, the lattice defects and the specific surface areas of TiO2 were substantially augmented by adding Co/I because of the increase of oxygen vacancies, especially for Co-I-TiO2.	Oxygen	136-142	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-108
33820487-5	2021	Also, the lattice defects and the specific surface areas of TiO2 were substantially augmented by adding Co/I because of the increase of oxygen vacancies, especially for Co-I-TiO2.	Oxygen	136-142	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	169-173
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Oxygen	84-90	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-169
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Oxygen	84-90	hypoxia inducible factor 1, alpha subunit	Mus musculus	171-181
1590606-1	1992	STUDY OBJECTIVE: This study evaluated the ability of emergency medical technicians (EMT-As) and emergency medical technicians-paramedics (EMT-Ps) to use pulse oximetry measurements in determining patient oxygen requirements.	Oxygen	204-210	IL2 inducible T cell kinase	Homo sapiens	84-87
1590606-1	1992	STUDY OBJECTIVE: This study evaluated the ability of emergency medical technicians (EMT-As) and emergency medical technicians-paramedics (EMT-Ps) to use pulse oximetry measurements in determining patient oxygen requirements.	Oxygen	204-210	IL2 inducible T cell kinase	Homo sapiens	138-141
1590606-5	1992	INTERVENTIONS: EMT-Ps and EMT-As predicted patients" supplemental oxygen requirements based on clinical assessment.	Oxygen	66-72	IL2 inducible T cell kinase	Homo sapiens	15-18
1590606-5	1992	INTERVENTIONS: EMT-Ps and EMT-As predicted patients" supplemental oxygen requirements based on clinical assessment.	Oxygen	66-72	IL2 inducible T cell kinase	Homo sapiens	26-29
1590606-15	1992	CONCLUSION: EMT-Ps were more likely to appropriately base oxygen therapy on oximetry measurements than were EMT-As.	Oxygen	58-64	IL2 inducible T cell kinase	Homo sapiens	12-15
33801748-2	2021	Target gases included both oxygen and carbon monoxide in nitrogen-based sample gas mixtures.	Oxygen	27-33	gastrin	Homo sapiens	7-10
25347858-6	2014	A step-wise differentiation protocol was used to generate Nkx2.1+ lung/thyroid progenitors under 20% and 5% oxygen tension.	Oxygen	108-114	NK2 homeobox 1	Mus musculus	58-64
25347858-7	2014	On day 12, gene expression analysis revealed that Nkx2.1 and Foxa2 (endodermal and early lung epithelial cell marker) were significantly upregulated at 5% oxygen tension in ESC and iPSC differentiated cultures compared to 20% oxygen conditions.	Oxygen	155-161	NK2 homeobox 1	Mus musculus	50-56
33805116-7	2021	Tert-butanol, isopropyl alcohol (IPA), Tiron, and Cu(NO3)2 were confirmed as adequate OH , h+, O2 - and e- scavengers.	Oxygen	95-97	telomerase reverse transcriptase	Homo sapiens	0-4
25347858-8	2014	In addition, quantification of Foxa2+Nkx2.1+Pax8- cells corresponding to the lung field, with exclusion of the potential thyroid fate identified by Pax8 expression, confirmed that the low physiologic oxygen tension exerted a significant positive effect on early pulmonary differentiation of ESC and iPSC.	Oxygen	200-206	NK2 homeobox 1	Mus musculus	37-43
1551892-6	1992	13C NMR studies using 18O-labeled L-aspartic acid demonstrate that glycoasparaginase catalyzes an oxygen exchange between water and the carboxyl group at C-4 of L-aspartic acid.	Oxygen	98-104	complement C4A (Rodgers blood group)	Homo sapiens	154-157
24726658-10	2014	CONCLUSIONS: A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1alpha and HIF-2alpha-mediated and TSA-sensitive chromatin modification mechanisms.	Oxygen	63-65	endothelial PAS domain protein 1	Homo sapiens	201-211
24787051-5	2014	This work aimed to determine the role of TGFbeta1, beta2 and beta3 in regulating EVT outgrowth in the low oxygen environment of early pregnancy.	Oxygen	106-112	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	61-66
1550207-7	1992	Although the acidic solution (70% O2-30% CO2) decreased pHi to 6.90 +/- 0.05 (P less than 0.01), there were no changes in the cell shape or [Ca2+]i.	Oxygen	34-36	glucose-6-phosphate isomerase	Rattus norvegicus	56-59
33941557-11	2021	Western blotting was used to detect the expression of PLAC1 under hypoxic conditions, and the cell viability and apoptosis of trophoblast cells in a low oxygen concentration after overexpression of PLAC1 were detected by CCK-8 and flow cytometry assay.	Oxygen	153-159	placenta enriched 1	Homo sapiens	198-203
33941557-14	2021	After treatment with alow oxygen concentration, the expression of PLAC1 protein was significantly reduced (p<0.05).	Oxygen	26-32	placenta enriched 1	Homo sapiens	66-71
33941557-15	2021	The overexpression of PLAC1 can reverse the cell viability of trophoblast cells (p<0.05) and inhibit apoptosis of trophoblast cells (p<0.05) in low oxygen concentration.	Oxygen	148-154	placenta enriched 1	Homo sapiens	22-27
24857662-4	2014	Disruption of endothelial p53 activation improved dietary inactivation of endothelial nitric oxide synthase that upregulated the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in skeletal muscle, thereby increasing mitochondrial biogenesis and oxygen consumption.	Oxygen	279-285	transformation related protein 53, pseudogene	Mus musculus	26-29
33587593-8	2021	In addition, we find that the presence of different oxygen functional groups at the surface of graphite dictates the oligomerization products and the LiF formation mechanism in the SEI.	Oxygen	52-58	LIF interleukin 6 family cytokine	Homo sapiens	150-153
1378120-1	1992	We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction of these ACE inhibitors with agents that purportedly prevent the deleterious action of oxygen-derived free radicals.	Oxygen	113-119	angiotensin I converting enzyme	Gallus gallus	62-65
24857662-4	2014	Disruption of endothelial p53 activation improved dietary inactivation of endothelial nitric oxide synthase that upregulated the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in skeletal muscle, thereby increasing mitochondrial biogenesis and oxygen consumption.	Oxygen	279-285	nitric oxide synthase 3, endothelial cell	Mus musculus	74-107
1311528-2	1992	In this study the effects of acute changes in in vitro oxygen tension on EDRF production were determined in isolated segments of ovine fetal intrapulmonary arteries (4th generation) obtained at 125-135 days of gestation (term 144 +/- 4 days).	Oxygen	55-61	alpha hemoglobin stabilizing protein	Homo sapiens	73-77
33237088-4	2020	As a result, CoP/Ni2P@HPNCP exhibits excellent pH universal hydrogen evolution reaction activity and alkaline oxygen evolution reaction activity.	Oxygen	110-116	caspase recruitment domain family member 16	Homo sapiens	13-16
24599965-2	2014	HIF-1alpha/ARNT and HIF-2alpha/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation.	Oxygen	178-180	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-10
1311528-6	1992	With decreasing oxygen tension, basal and ACh-stimulated cGMP production were attenuated, whereas cGMP production with SNP was not, indicating oxygen modulation of EDRF production.	Oxygen	16-22	alpha hemoglobin stabilizing protein	Homo sapiens	164-168
1311528-6	1992	With decreasing oxygen tension, basal and ACh-stimulated cGMP production were attenuated, whereas cGMP production with SNP was not, indicating oxygen modulation of EDRF production.	Oxygen	143-149	alpha hemoglobin stabilizing protein	Homo sapiens	164-168
1311528-10	1992	These findings indicate that oxygen selectively modulates EDRF production and endothelium-dependent relaxation in ovine fetal pulmonary arteries.	Oxygen	29-35	alpha hemoglobin stabilizing protein	Homo sapiens	58-62
1311528-11	1992	Direct effects of oxygen on EDRF production may at least partially underlie the responses of the developing pulmonary circulation to changes in oxygenation.	Oxygen	18-24	alpha hemoglobin stabilizing protein	Homo sapiens	28-32
1737854-10	1992	PCr and pHi in animals after hyperbaric O2 improved within 45 min, but also remained below control at 90 min.	Oxygen	40-42	glucose-6-phosphate isomerase	Rattus norvegicus	8-11
1552891-1	1992	In in-vitro study, human immunoglobulin (Ig) denatured by O2 bubbling markedly produced C4a, C3a, and C5a, whereas human albumin treated identically did not.	Oxygen	58-60	complement C4A (Rodgers blood group)	Homo sapiens	88-91
24599965-2	2014	HIF-1alpha/ARNT and HIF-2alpha/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation.	Oxygen	178-180	aryl hydrocarbon receptor nuclear translocator	Mus musculus	11-15
24599965-2	2014	HIF-1alpha/ARNT and HIF-2alpha/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation.	Oxygen	178-180	endothelial PAS domain protein 1	Mus musculus	20-30
1391438-5	1992	The latest addition is Tri-(3,5,dibromosalicyl)-benzenetricarboxylate, which crosslinks both human and bovine hemoglobin across the beta subunits, decreasing the oxygen affinity of both proteins.	Oxygen	162-168	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	23-26
24599965-2	2014	HIF-1alpha/ARNT and HIF-2alpha/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation.	Oxygen	178-180	aryl hydrocarbon receptor nuclear translocator	Mus musculus	31-35
24439479-5	2014	Additionally, among ApoE3+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was positively correlated with p-tau (r = 0.30, p = 0.023), t-tau (r = 0.31, p = 0.021), and Abeta-42 (r = 0.31, p = 0.021).	Oxygen	71-73	microtubule associated protein tau	Homo sapiens	126-129
1591927-3	1992	These results suggest that the influence of elastin peptides on oxygen metabolism may be related to their activities in vivo following elastin degradation and can contribute to their role in the pathogenesis of atherosclerosis.	Oxygen	64-70	elastin	Mus musculus	44-51
1591927-3	1992	These results suggest that the influence of elastin peptides on oxygen metabolism may be related to their activities in vivo following elastin degradation and can contribute to their role in the pathogenesis of atherosclerosis.	Oxygen	64-70	elastin	Mus musculus	135-142
24757104-0	2014	Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1alpha/beta-catenin pathway in middle cerebral artery occlusion rats.	Oxygen	19-25	catenin beta 1	Rattus norvegicus	120-132
1483584-3	1992	Exposure to 85% O2 increased lung catalase, glutathione peroxidase and manganese superoxide dismutase activities in comparison to air controls.	Oxygen	16-18	catalase	Cavia porcellus	34-42
1542209-14	1992	PAM with IL-2 pretreatment and PAM with GM-CSF pretreatment also released somewhat increased amount of O2-.	Oxygen	103-105	colony stimulating factor 2	Homo sapiens	40-46
24817692-0	2014	DNMT3a epigenetic program regulates the HIF-2alpha oxygen-sensing pathway and the cellular response to hypoxia.	Oxygen	51-57	DNA methyltransferase 3 alpha	Homo sapiens	0-6
1731157-1	1992	Hyperbaric oxygen therapy (HBO) involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm.	Oxygen	11-17	ATM serine/threonine kinase	Homo sapiens	112-115
1731157-1	1992	Hyperbaric oxygen therapy (HBO) involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm.	Oxygen	73-79	ATM serine/threonine kinase	Homo sapiens	112-115
24817692-0	2014	DNMT3a epigenetic program regulates the HIF-2alpha oxygen-sensing pathway and the cellular response to hypoxia.	Oxygen	51-57	endothelial PAS domain protein 1	Homo sapiens	40-50
24817692-4	2014	Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with hypoxic cell growth, thereby limiting the proliferative capacity of adult cells under low oxygen tension.	Oxygen	187-193	endothelial PAS domain protein 1	Homo sapiens	24-29
24817692-4	2014	Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with hypoxic cell growth, thereby limiting the proliferative capacity of adult cells under low oxygen tension.	Oxygen	187-193	endothelial PAS domain protein 1	Homo sapiens	57-67
24817692-6	2014	This enables incipient cancer cells to exploit the HIF-2alpha pathway in the hypoxic tumor microenvironment necessary for the formation of cellular masses larger than the oxygen diffusion limit.	Oxygen	171-177	endothelial PAS domain protein 1	Homo sapiens	51-61
1662497-2	1991	Recent demonstrations that .O2- inactivates the potent vasodilator endothelium-derived relaxing factor (EDRF) and that EDRF is probably nitric oxide (NO) suggest that EDRF(NO) may act as an endogenous free radical scavenger.	Oxygen	28-30	alpha hemoglobin stabilizing protein	Homo sapiens	67-102
24817692-8	2014	These data support a tumor-suppressive role for DNMT3a as an epigenetic regulator of the HIF-2alpha oxygen-sensing pathway and the cellular response to hypoxia.	Oxygen	100-106	DNA methyltransferase 3 alpha	Homo sapiens	48-54
1662497-2	1991	Recent demonstrations that .O2- inactivates the potent vasodilator endothelium-derived relaxing factor (EDRF) and that EDRF is probably nitric oxide (NO) suggest that EDRF(NO) may act as an endogenous free radical scavenger.	Oxygen	28-30	alpha hemoglobin stabilizing protein	Homo sapiens	104-108
1662497-7	1991	These observations indicate that NO(EDRF) can be regarded as a scavenger of superoxide anion and they suggest that EDRF(NO) may provide a chemical barrier to cytotoxic free radicals (.O2-).	Oxygen	184-186	alpha hemoglobin stabilizing protein	Homo sapiens	36-40
24817692-8	2014	These data support a tumor-suppressive role for DNMT3a as an epigenetic regulator of the HIF-2alpha oxygen-sensing pathway and the cellular response to hypoxia.	Oxygen	100-106	endothelial PAS domain protein 1	Homo sapiens	89-99
1662497-7	1991	These observations indicate that NO(EDRF) can be regarded as a scavenger of superoxide anion and they suggest that EDRF(NO) may provide a chemical barrier to cytotoxic free radicals (.O2-).	Oxygen	184-186	alpha hemoglobin stabilizing protein	Homo sapiens	115-119
24855117-2	2014	Here we used a novel reagent, the ODD-Luc hypoxia reporter mouse (oxygen degradation domain, ODD) of Hif-1alpha fused to Luciferase (Luc), to assay the activity of the oxygen sensor, prolyl hydroxylase, and oxygen reserve, in the developing heart.	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
24855117-2	2014	Here we used a novel reagent, the ODD-Luc hypoxia reporter mouse (oxygen degradation domain, ODD) of Hif-1alpha fused to Luciferase (Luc), to assay the activity of the oxygen sensor, prolyl hydroxylase, and oxygen reserve, in the developing heart.	Oxygen	168-174	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
1750523-6	1991	Thus inhibitors of oxidative phosphorylation did not mimic the effects of hypoxia, indicating that oxygen-dependent expression of the EPO gene in the kidney is not effected through hypoxic compromise of oxidative phosphorylation.	Oxygen	99-105	erythropoietin	Rattus norvegicus	134-137
1750555-3	1991	In perfused heart, the deoxymyoglobin"s response to tissue oxygenation precedes the one reflected in the 31P phosphocreatine or ATP signals, suggesting that oxidative energy metabolism is still sufficient even when the myoglobin is partially saturated with oxygen.	Oxygen	59-65	myoglobin	Homo sapiens	28-37
1958383-0	1991	Tumor necrosis factor enhances endothelial cell susceptibility to oxygen toxicity: role of glutathione.	Oxygen	66-72	tumor necrosis factor	Canis lupus familiaris	0-21
1961720-0	1991	Functional analysis of an oxygen-regulated transcriptional enhancer lying 3" to the mouse erythropoietin gene.	Oxygen	26-32	erythropoietin	Mus musculus	90-104
1718337-6	1991	SMC cultured in 3% and 10% O2 for 120 h showed dose-dependent decreases (11-fold and 2-fold, respectively) in measured tropoelastin levels compared with SMC cultured in 21% O2 conditions.	Oxygen	27-29	elastin	Bos taurus	119-131
24855117-2	2014	Here we used a novel reagent, the ODD-Luc hypoxia reporter mouse (oxygen degradation domain, ODD) of Hif-1alpha fused to Luciferase (Luc), to assay the activity of the oxygen sensor, prolyl hydroxylase, and oxygen reserve, in the developing heart.	Oxygen	168-174	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
24884370-1	2014	BACKGROUND: The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance.	Oxygen	162-168	endothelial PAS domain protein 1	Homo sapiens	16-48
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	92-98	CCAAT enhancer binding protein zeta	Homo sapiens	0-3
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	92-98	CCAAT enhancer binding protein zeta	Homo sapiens	158-161
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	92-98	CCAAT enhancer binding protein zeta	Homo sapiens	172-186
24884370-1	2014	BACKGROUND: The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance.	Oxygen	162-168	endothelial PAS domain protein 1	Homo sapiens	50-55
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	105-111	CCAAT enhancer binding protein zeta	Homo sapiens	0-3
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	105-111	CCAAT enhancer binding protein zeta	Homo sapiens	158-161
24810628-9	2014	Isolated heart mitochondrial studies showed significantly altered O2-consumption, ROS production, matrix calcium, and mitochondrial membrane potential in miR-181c-treated animals.	Oxygen	66-68	microRNA 181c	Rattus norvegicus	154-162
1802460-5	1991	CBF of gray matter in healthy volunteers correlated with CBV and cerebral metabolic rate of oxygen where oxygen extraction fraction inversely correlated with CBF, CBV, and CBF/CBV; and 3.	Oxygen	105-111	CCAAT enhancer binding protein zeta	Homo sapiens	172-186
24725143-11	2014	For most cases, the oxygen plasma treatment can effectively prevent phthalate leaching from PVC films (e.g., for samples with low bulk concentrations of DBP-5 and 30 wt %).	Oxygen	20-26	DEAD-box helicase 19B	Homo sapiens	153-158
1959501-12	1991	Animals exposed to 85% O2 had a 60% increase of plasma immunoreactive PDGF and a 90% increase of plasma immunoreactive IGF-1, compared with values for control animals exposed to air.	Oxygen	23-25	insulin-like growth factor 1	Rattus norvegicus	119-124
24725094-8	2014	Met-1 displays higher susceptibility to oxidative damage compared to Met-5 because it is directly involved in both Cu(II) and Cu(I) coordination, resulting in closer exposure to the reactive oxygen species that may be generated by the redox cycling of copper.	Oxygen	191-197	granzyme M	Homo sapiens	0-5
1820005-9	1991	Pretreatment with an active oxygen scavenger, SOD, markedly reduces the rise in serum amylase and lipase levels.	Oxygen	28-34	lipase G, endothelial type	Rattus norvegicus	98-104
24631040-1	2014	Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance.	Oxygen	100-106	glutathione peroxidase 3	Mus musculus	0-24
1715975-8	1991	We concluded that: (i) CYP1 is an efficient activator especially in heme-depleted cells; (ii) CYP1 exerts both positive and negative regulatory effects; (iii) the nature of the regulatory function of CYP1 depends on the target gene; and (iv) for a given gene, the presence or absence of heme or oxygen reverses the sense of CYP1-dependent regulation.	Oxygen	295-301	Hap1p	Saccharomyces cerevisiae S288C	23-27
1715975-8	1991	We concluded that: (i) CYP1 is an efficient activator especially in heme-depleted cells; (ii) CYP1 exerts both positive and negative regulatory effects; (iii) the nature of the regulatory function of CYP1 depends on the target gene; and (iv) for a given gene, the presence or absence of heme or oxygen reverses the sense of CYP1-dependent regulation.	Oxygen	295-301	Hap1p	Saccharomyces cerevisiae S288C	94-98
1715975-8	1991	We concluded that: (i) CYP1 is an efficient activator especially in heme-depleted cells; (ii) CYP1 exerts both positive and negative regulatory effects; (iii) the nature of the regulatory function of CYP1 depends on the target gene; and (iv) for a given gene, the presence or absence of heme or oxygen reverses the sense of CYP1-dependent regulation.	Oxygen	295-301	Hap1p	Saccharomyces cerevisiae S288C	94-98
1715975-8	1991	We concluded that: (i) CYP1 is an efficient activator especially in heme-depleted cells; (ii) CYP1 exerts both positive and negative regulatory effects; (iii) the nature of the regulatory function of CYP1 depends on the target gene; and (iv) for a given gene, the presence or absence of heme or oxygen reverses the sense of CYP1-dependent regulation.	Oxygen	295-301	Hap1p	Saccharomyces cerevisiae S288C	94-98
24631040-1	2014	Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance.	Oxygen	100-106	glutathione peroxidase 3	Mus musculus	26-30
24733837-3	2014	Here, we show that hyperpolarization-activated, cAMP-gated (HCN) channels--which conduct the hyperpolarization-activated current (Ih) and the voltage-insensitive instantaneous current (Iinst), and contribute to diverse physiological functions including learning and memory, cardiac pacemaking, and the sensation of pain--are subject to modification by (1)O2.	Oxygen	355-357	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
2065777-1	1991	Rat hepatic phenylalanine hydroxylase requires both a tetrahydropterin cofactor and molecular oxygen to convert phenylalanine to tyrosine.	Oxygen	94-100	phenylalanine hydroxylase	Rattus norvegicus	12-37
2050109-2	1991	Since resistance to such conditions may be correlated with the activity of enzymes involved in oxygen detoxification, we have generated transgenic tobacco plants which express elevated levels of manganese superoxide dismutase (MnSOD) within their chloroplasts or mitochondria.	Oxygen	95-101	superoxide dismutase [Mn], mitochondrial-like	Nicotiana tabacum	195-225
2050109-2	1991	Since resistance to such conditions may be correlated with the activity of enzymes involved in oxygen detoxification, we have generated transgenic tobacco plants which express elevated levels of manganese superoxide dismutase (MnSOD) within their chloroplasts or mitochondria.	Oxygen	95-101	superoxide dismutase [Mn], mitochondrial-like	Nicotiana tabacum	227-232
32795718-8	2020	Moreover, the thioether sulfur on the straight chain was more susceptible to oxygen transfer with PMS than that on the thiazole ring of HRAs.	Oxygen	77-83	HRas proto-oncogene, GTPase	Homo sapiens	136-140
24733837-6	2014	The modification of HCN channel function is a photodynamic process that involves (1)O2, as supported by the dependence on dissolved oxygen in solutions, the inhibitory effect by a (1)O2 scavenger, and the results with the HCN2-SOG fusion protein.	Oxygen	81-86	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	20-23
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	interleukin 1 alpha	Homo sapiens	108-112
24733837-6	2014	The modification of HCN channel function is a photodynamic process that involves (1)O2, as supported by the dependence on dissolved oxygen in solutions, the inhibitory effect by a (1)O2 scavenger, and the results with the HCN2-SOG fusion protein.	Oxygen	132-138	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	20-23
23900229-4	2013	The Co-Pi oxygen evolution catalyst was deposited onto the BiVO4/1D-WO3/FTO heterojunction electrode using a photoassisted electrodeposition method.	Oxygen	10-16	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	72-75
24733837-6	2014	The modification of HCN channel function is a photodynamic process that involves (1)O2, as supported by the dependence on dissolved oxygen in solutions, the inhibitory effect by a (1)O2 scavenger, and the results with the HCN2-SOG fusion protein.	Oxygen	180-185	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	20-23
23900229-6	2013	The improved photoelectrochemical properties profited from the enhanced charge carrier separation achieved through the integration of highly porous BiVO4 layers on top of 1D-WO3 nanorods and from the superior kinetics due to the presence of the Co-Pi oxygen evolution catalyst on top of BiVO4/1D-WO3/FTO heterojunction electrodes.	Oxygen	251-257	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	300-303
1647676-1	1991	We tested the possibility that platelet-activating factor (PAF) exerts some of its actions on the microvascular and mucosal membranes by stimulating the production of reactive O2 metabolites.	Oxygen	176-178	PCNA clamp associated factor	Homo sapiens	31-57
24733837-8	2014	We identified a histidine residue (H434 in S6) near the activation gate in the pore critical for (1)O2 modulation of HCN function.	Oxygen	97-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	117-120
1647676-1	1991	We tested the possibility that platelet-activating factor (PAF) exerts some of its actions on the microvascular and mucosal membranes by stimulating the production of reactive O2 metabolites.	Oxygen	176-178	PCNA clamp associated factor	Homo sapiens	59-62
24612287-9	2014	Therefore, here we investigated whether oxygen tension influences DC expression of IDO in the context of homoeostatic and altered redox.	Oxygen	40-46	indoleamine 2,3-dioxygenase 1	Homo sapiens	83-86
1647676-10	1991	We conclude that the PAF-induced increase in mucosal permeability to 51Cr-EDTA is mediated by reactive O2 metabolites produced by resident phagocytic cells.	Oxygen	103-105	PCNA clamp associated factor	Homo sapiens	21-24
1645525-0	1991	Some reactions of carbon monoxide and oxygen with carbodi-imide-modified cytochrome c.	Oxygen	38-44	cytochrome c, somatic	Equus caballus	73-85
21345980-7	2011	RESULTS: RES incubation under 40% oxygen increased the expression of FoxO1A, FoxO3A, and FoxO4.	Oxygen	34-40	forkhead box O4	Homo sapiens	89-94
21364630-7	2010	Western blotting revealed significantly upregulated oxygen-sensitive transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, while producing a biphasic response within HIF targets, including erythropoietin, vascular endothelial growth factor and Bcl-2 family members, during hypoxia and subsequent reoxygenation.	Oxygen	52-58	endothelial PAS domain protein 1	Homo sapiens	133-143
24717022-6	2014	Compared to similar systems in which monomeric porphyrins are simply physisorbed, MWNT-CoP hybrids showed a higher ORR activity associated with a number of exchanged electrons close to four, corresponding to the complete reduction of oxygen into water.	Oxygen	234-240	caspase recruitment domain family member 16	Homo sapiens	87-90
12849743-2	2003	The in vitro studies of organotypic cultures from hippocampus evidenced that P2X2 and P2X4 were up-regulated by glucose/oxygen deprivation.	Oxygen	120-126	purinergic receptor P2X 2	Homo sapiens	77-81
1902636-6	1991	Forty-eight hours after PLA2 administration experimental animals had lower arterial oxygen tensions (73.9 +/- 7.66 mm Hg versus 96.7 +/- 2.52 mm Hg, mean +/- SEM; p less than 0.01), higher alveolar-arterial oxygen gradients (35.3 +/- 6.3 mm Hg versus 18.8 +/- 1.42 mm Hg, p less than 0.01), and higher wet-dry lung weight ratios (5.08 +/- 0.26, mean +/- SEM, n = 7 versus 3.29 +/- 0.08, n = 3; p less than 0.002) than did control animals.	Oxygen	84-90	phospholipase A2 group IB	Rattus norvegicus	24-28
2019268-2	1991	The renal O2-sensing mechanism in the control of the synthesis of Epo is still poorly understood.	Oxygen	10-12	erythropoietin	Rattus norvegicus	66-69
24369291-1	2014	Decreased cerebral blood volume/flow (CBV/CBF) contributes to negative blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signals.	Oxygen	77-83	CCAAT enhancer binding protein zeta	Homo sapiens	42-45
2019268-8	1991	The release of Epo during hypoxic perfusion (pO2 35 and 20 mm Hg) was little affected by changes in the hematocrit, i.e. the O2-carrying capacity of the perfusion medium over a wide range (0-40%).	Oxygen	46-48	erythropoietin	Rattus norvegicus	15-18
2019268-9	1991	These results indicate that the production of Epo in the isolated perfused kidney depends on the availability of O2 and can be modulated by changes in the arterial pO2.	Oxygen	113-115	erythropoietin	Rattus norvegicus	46-49
34848056-0	2022	One-dimensional CoP/MnO hollow nanostructures with enhanced oxygen evolution reaction activity.	Oxygen	60-66	caspase recruitment domain family member 16	Homo sapiens	16-19
24736588-4	2014	TIMP-3 KO mice had higher body temperature, oxygen consumption, and carbon dioxide production than wild-type (WT) mice, although there were no differences in food intake and locomotor activity.	Oxygen	44-50	tissue inhibitor of metalloproteinase 3	Mus musculus	0-6
34973372-9	2022	IL-2 had no effect on the secretion of neurotoxins and nitric oxide by microglia-like cells, but it selectively regulated phagocytic activity and reactive oxygen species production by stimulated microglia-like cells.	Oxygen	155-161	interleukin 2	Mus musculus	0-4
34973372-10	2022	Modulation of microglial reactive oxygen species through altered brain IL-2 concentrations could be one of the mechanisms linking diets with modified risk of neuroimmune disorders including Parkinson"s disease.	Oxygen	34-40	interleukin 2	Mus musculus	71-75
34973646-14	2022	The cTnI level was negatively correlated (p < 0.05) with the parameters Apgar score, heart rate, peripheral oxygen saturation (sO2) level, reflex score, and total carbon dioxide (TCO2) level and positively correlated (p < 0.01) with lactate level.	Oxygen	108-114	troponin I3, cardiac type	Canis lupus familiaris	4-8
34758919-4	2022	NiCo2O4/CoP core-shell fluffy polyhedrons are derived from metal-organic frameworks with rich oxygen vacancies and abundant characteristics of pseudocapacitance, as well as better wettability.	Oxygen	94-100	caspase recruitment domain family member 16	Homo sapiens	8-11
1849943-7	1991	Cells primed by PAF exhibited faster initial rates of O2-production after addition of FMLP, but the duration of O2- production was not prolonged.	Oxygen	54-56	PCNA clamp associated factor	Homo sapiens	16-19
1849943-8	1991	Whereas PAF-primed responses to FMLP are usually associated with increases in intracellular calcium [( Ca2+]i) after addition of FMLP, two conditions were found in which O2- responses to FMLP in PAF-primed cells occurred in the absence of any detectable increase in [Ca2+]i.	Oxygen	170-172	PCNA clamp associated factor	Homo sapiens	195-198
1849943-10	1991	These data confirm the requirement of [Ca2+]o for optimal priming of neutrophils by PAF and ionomycin (but not cells primed by PMA) and indicate that, under certain conditions, generation of O2- in response to FMLP in PAF-primed neutrophils can occur independent of any increase in [Ca2+]i.	Oxygen	191-193	PCNA clamp associated factor	Homo sapiens	218-221
1875559-7	1991	Our results suggest that improvement of exercise capacity and ST depression in patients with chronic hemodialysis is the outcome of increased coronary oxygen supply with unchanged cardiac oxygen demand after correction of renal anemia treated with rEPO.	Oxygen	151-157	erythropoietin	Rattus norvegicus	248-252
1649989-7	1991	Our findings suggest that the oxygen-sensing mechanism that controls renal erythropoietin production is primarily located in the kidney itself.	Oxygen	30-36	erythropoietin	Rattus norvegicus	75-89
24673361-3	2014	When exposed to O2, it transformed from an EPR inactive to an EPR active species indicative of oxidation of Co(I) to Co(II) with the formation of H2O2.	Oxygen	16-18	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	108-113
34903421-0	2022	Retraction notice to "Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5" (Biomed.	Oxygen	45-51	microRNA 21	Homo sapiens	108-119
2051891-5	1991	The similarity of the effects of catalase and superoxide dismutase and stimulation of two different steps of the omega-oxidation pathway suggest that these agents are acting indirectly by removing active oxygen species rather than directly on the enzymes of microsomal fatty acid omega-hydroxylation.	Oxygen	204-210	catalase	Ovis aries	33-41
24554704-7	2014	We found that a high O2 condition repressed Notch-dependent gene Hes1 expression and increased Ngn3 expression at the stage of pancreatic progenitors.	Oxygen	21-23	neurogenin 3	Homo sapiens	95-99
1843842-4	1991	In the second group he CBF is closely coupled to and regulated by the cerebral metabolic rate of oxygen (CMRO2) and values of SvO2 are intermediate.	Oxygen	97-103	CCAAT enhancer binding protein zeta	Homo sapiens	23-26
34904400-4	2022	Expression of HIF-1alpha, glucose transporter 1, and vascular endothelial growth factor was induced under hypoxia (5% O2 ).	Oxygen	118-120	hypoxia inducible factor 1, alpha subunit	Mus musculus	14-24
24508125-1	2014	Prolyl hydroxylase domain (PHD) proteins catalyze oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor 1alpha and 2alpha, tagging them for pVHL-dependent polyubiquitination and proteasomal degradation.	Oxygen	50-56	hypoxia inducible factor 1, alpha subunit	Mus musculus	91-133
1687968-1	1991	The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied.	Oxygen	18-20	PCNA clamp associated factor	Homo sapiens	42-45
25004828-8	2014	CRH also up-regulates IL-18 expression by increasing intracellular reactive oxygen in microglia cells.	Oxygen	76-82	corticotropin releasing hormone	Homo sapiens	0-3
1765736-1	1991	A non-linear partial differential equation is analyzed using multiple scale techniques and similarity transformations in order to examine the role of hemoglobin and myoglobin in facilitating oxygen transport to tissue.	Oxygen	191-197	myoglobin	Homo sapiens	165-174
24201705-4	2014	Two of these loci, EGLN1 and EPAS1, encode major components of the hypoxia-inducible factor transcriptional system, which has a central role in oxygen sensing and coordinating an organism"s response to hypoxia, as evidenced by studies in humans and mice.	Oxygen	144-150	endothelial PAS domain protein 1	Homo sapiens	29-34
2085744-5	1990	The survival of microtubule-associated protein 2 (MAP2)-positive neurons in culture from P3 basal forebrain regions was more enhanced in a 50% O2 atmosphere than in 20% and also 10% O2 atmosphere.	Oxygen	143-145	microtubule-associated protein 2	Rattus norvegicus	16-48
24663218-2	2014	KatA is the major catalase of PA that detoxifies hydrogen peroxide (H2O2), a reactive oxygen intermediate generated during aerobic respiration.	Oxygen	86-92	catalase	Pseudomonas aeruginosa PAO1	0-4
2247305-3	1990	The serum myoglobin value was significantly higher in cases needing oxygen therapy over 60% oxygen.	Oxygen	68-74	myoglobin	Homo sapiens	10-19
2247305-3	1990	The serum myoglobin value was significantly higher in cases needing oxygen therapy over 60% oxygen.	Oxygen	92-98	myoglobin	Homo sapiens	10-19
24658033-5	2014	Moreover, HSP40 was involved in regulating glucose metabolism on PKM2 dependent way and at the mean time had an effect on mitochondrial oxygen respiration.	Oxygen	136-142	pyruvate kinase M1/2	Homo sapiens	65-69
2237979-2	1990	If oxygen is withdrawn from rat hippocampal slices, a spreading depression-like response occurs earlier and is of larger amplitude in the CA1 area than in the dentate gyrus.	Oxygen	3-9	carbonic anhydrase 1	Rattus norvegicus	138-141
24506136-1	2014	In the social amoeba Dictyostelium, Skp1 is hydroxylated on proline 143 and further modified by three cytosolic glycosyltransferases to yield an O-linked pentasaccharide that contributes to O2 regulation of development.	Oxygen	190-192	S-phase kinase associated protein 1	Homo sapiens	36-40
2145996-5	1990	A significant correlation was found between Ptc,O2 and Psa,O2 in patients with ischaemia (r = 0.68, P less than 0.01).	Oxygen	59-61	coiled-coil domain containing 6	Homo sapiens	44-47
2145996-8	1990	Ptc,O2 increased from 38(13) to 44(1) mmHg (P greater than 0.05) and mean(s.d.)	Oxygen	4-6	coiled-coil domain containing 6	Homo sapiens	0-3
24375723-0	2014	Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1alpha-mediated transcriptional regulation.	Oxygen	0-6	hypoxia inducible factor 1, alpha subunit	Mus musculus	123-154
24022988-4	2014	Incubation of adult rat CPCs in CdM from human MSCs isolated by plastic adherence or by magnetic sorting against CD271 (a.k.a., p75 low-affinity nerve growth factor receptor; p75MSCs) induced phosphorylation of STAT3 and Akt in CPCs, supporting their proliferation under normoxic conditions and survival under hypoxic conditions (1% oxygen).	Oxygen	333-339	nerve growth factor receptor	Homo sapiens	113-118
2203787-12	1990	Low rates of NADPH-dependent O2 consumption can be elicited by SOC II and SOC III in the absence of SOC I.	Oxygen	29-31	UBX domain protein 11	Homo sapiens	63-68
2203787-14	1990	Plasma membranes, incubated with SOC I plus GTP gamma S and re-isolated, showed a similar 3-4-fold enhanced O2 consumption with SOC II and SOC III.	Oxygen	108-110	UBX domain protein 11	Homo sapiens	33-38
2095759-1	1990	Transcutaneous oxygen tension (Ptc,O2) was assessed as an indicator of risk of reulceration in 68 limbs with healed venous ulcers.	Oxygen	15-21	coiled-coil domain containing 6	Homo sapiens	31-34
2095759-9	1990	The Ptc,O2 ratio was significantly increased in limbs treated by stanozolol and elastic stockings (P less than 0.05) and by surgery and elastic stockings (P less than 0.05).	Oxygen	8-10	coiled-coil domain containing 6	Homo sapiens	4-7
1697466-1	1990	Granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) increased neutrophil C3bi-receptor expression and adherence and rapidly (less than 10 min) primed neutrophils to enhanced O2- release and membrane depolarization stimulated by chemotactic peptide.	Oxygen	229-231	colony stimulating factor 3	Homo sapiens	0-43
24644426-1	2014	OBJECTIVE: To investigate the relationship between oxygen sensitivity of trophoblast and hypoxia in preeclamptic placenta by the study on the expressions of hypoxia-inducible factor prolyl 4-hydroxylase (PHD) and hypoxia-inducible factor (HIF) in placentas from normal pregnant women and patients with pre-eclampsia.	Oxygen	51-57	prolyl 4-hydroxylase, transmembrane	Homo sapiens	157-202
1697466-1	1990	Granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) increased neutrophil C3bi-receptor expression and adherence and rapidly (less than 10 min) primed neutrophils to enhanced O2- release and membrane depolarization stimulated by chemotactic peptide.	Oxygen	229-231	colony stimulating factor 2	Homo sapiens	49-97
1697466-1	1990	Granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) increased neutrophil C3bi-receptor expression and adherence and rapidly (less than 10 min) primed neutrophils to enhanced O2- release and membrane depolarization stimulated by chemotactic peptide.	Oxygen	229-231	colony stimulating factor 2	Homo sapiens	99-105
1697466-2	1990	Direct triggering of O2- release in suspended neutrophils was also provoked by GM-CSF but not by G-CSF.	Oxygen	21-23	colony stimulating factor 2	Homo sapiens	79-85
24754980-10	2014	Additionally, after adjustment for BMI and age, serum LPL levels showed significant negative correlations with TC and LDL (r = 0.221,0.199) .Serum LPL level was negative correlated with AHI and TS90 % and oxygen decrease index (ODI) (r = 0.231,0.228,0.184).	Oxygen	205-211	lipoprotein lipase	Homo sapiens	54-57
2171242-6	1990	The oxygen induction of the gene was found to be identical to that of the CYC1 gene, indicating that these two genes share similar or closely related cis- and trans-acting oxygen regulatory elements.	Oxygen	4-10	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	74-78
2171242-6	1990	The oxygen induction of the gene was found to be identical to that of the CYC1 gene, indicating that these two genes share similar or closely related cis- and trans-acting oxygen regulatory elements.	Oxygen	172-178	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	74-78
24754980-10	2014	Additionally, after adjustment for BMI and age, serum LPL levels showed significant negative correlations with TC and LDL (r = 0.221,0.199) .Serum LPL level was negative correlated with AHI and TS90 % and oxygen decrease index (ODI) (r = 0.231,0.228,0.184).	Oxygen	205-211	lipoprotein lipase	Homo sapiens	147-150
24442442-0	2014	Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.	Oxygen	143-149	FYVE and coiled-coil domain autophagy adaptor 1	Homo sapiens	14-19
2370851-12	1990	Thus, important phase I and II detoxification reactions are regulated indirectly by the hepatic oxygen gradient, via mechanisms involving cofactor supply, when cytochrome P-450 is not limiting.	Oxygen	96-102	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	160-176
24442442-0	2014	Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.	Oxygen	143-149	C-type lectin domain containing 7A	Homo sapiens	35-43
24442442-5	2014	When FYCO1 is lacking, phagosomes stay p40phox(+) longer and produce more reactive oxygen.	Oxygen	83-89	FYVE and coiled-coil domain autophagy adaptor 1	Homo sapiens	5-10
2162210-3	1990	Labelling studies have shown that the C-2 oxygen in the p-quinone dimer is derived from molecular oxygen.	Oxygen	42-48	complement C2	Homo sapiens	38-41
2162210-3	1990	Labelling studies have shown that the C-2 oxygen in the p-quinone dimer is derived from molecular oxygen.	Oxygen	98-104	complement C2	Homo sapiens	38-41
24744892-6	2014	At rest, Epo-TAg(h) mice displayed normal ventilatory parameters at 21% O2 but did not respond to acute hypoxia despite a larger expression of NMDA receptors and nNOS in the medulla.	Oxygen	72-74	erythropoietin	Mus musculus	9-12
24285264-5	2014	The expression of plod1, plod2, and plod3 was upregulated in the lungs of mouse pups exposed to 85% O2, an experimental animal model of BPD.	Oxygen	100-102	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Mus musculus	18-23
2337157-3	1990	We found that serum immunoreactive EPO levels in rats peaked after 12-h exposure to 7.5 or 9% oxygen (2,949 +/- 600 and 756 +/- 108 mU/ml, respectively, mean +/- SE) and declined to 29 and 64% of peak levels, respectively, after 36 h of hypoxia.	Oxygen	94-100	erythropoietin	Rattus norvegicus	35-38
2337157-4	1990	EPO levels in response to 11.5% oxygen showed no consistent change between 12 (122 +/- 21 mU/ml, mean +/- SE) and 36 h (182 +/- 35 mU/ml) of hypoxia.	Oxygen	32-38	erythropoietin	Rattus norvegicus	0-3
2337157-5	1990	The decline in EPO levels under severe hypoxia (7.5% O2) was paralleled by a marked reduction in renal EPO mRNA content, indicating that it was primarily a result of diminished hormone production.	Oxygen	53-55	erythropoietin	Rattus norvegicus	15-18
2337157-6	1990	The observed reductions in serum EPO after 36 h corresponded to preceding declines of calculated EPO production rates from 163- to 62-fold (7.5% O2) and 36- to 25-fold (9% O2) basal values.	Oxygen	145-147	erythropoietin	Rattus norvegicus	33-36
2337157-6	1990	The observed reductions in serum EPO after 36 h corresponded to preceding declines of calculated EPO production rates from 163- to 62-fold (7.5% O2) and 36- to 25-fold (9% O2) basal values.	Oxygen	145-147	erythropoietin	Rattus norvegicus	97-100
2337157-6	1990	The observed reductions in serum EPO after 36 h corresponded to preceding declines of calculated EPO production rates from 163- to 62-fold (7.5% O2) and 36- to 25-fold (9% O2) basal values.	Oxygen	172-174	erythropoietin	Rattus norvegicus	33-36
24285264-5	2014	The expression of plod1, plod2, and plod3 was upregulated in the lungs of mouse pups exposed to 85% O2, an experimental animal model of BPD.	Oxygen	100-102	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	25-30
24285264-5	2014	The expression of plod1, plod2, and plod3 was upregulated in the lungs of mouse pups exposed to 85% O2, an experimental animal model of BPD.	Oxygen	100-102	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	36-41
24355420-6	2014	Exposure to 1% O2 prior to PCB 126 treatment significantly inhibited CYP1A1 mRNA and protein expression in human HepG2 and HaCaT cells.	Oxygen	15-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75
2108173-9	1990	Damage by active oxygen species, pressure overload, and derangements of protein synthesis is likely to include the causative factors of increased expression of c-fos and the hsp 70 gene family in postischemic reperfused liver.	Oxygen	17-23	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	174-180
2315505-7	1990	These results show that intrarenal administration of contrast medium induces a transient increase in urinary THP mediated in part by oxygen free radical damage to the kidney.	Oxygen	133-139	uromodulin	Canis lupus familiaris	109-112
2337581-4	1990	In the model of this reaction intermediate, fitted to the active site of p-hydroxybenzoate hydroxylase, all possible positions of the distal oxygen were surveyed by rotating this oxygen about the single bond between the C4a and the proximal oxygen.	Oxygen	141-147	complement C4A (Rodgers blood group)	Homo sapiens	220-223
2337581-4	1990	In the model of this reaction intermediate, fitted to the active site of p-hydroxybenzoate hydroxylase, all possible positions of the distal oxygen were surveyed by rotating this oxygen about the single bond between the C4a and the proximal oxygen.	Oxygen	179-185	complement C4A (Rodgers blood group)	Homo sapiens	220-223
2337581-4	1990	In the model of this reaction intermediate, fitted to the active site of p-hydroxybenzoate hydroxylase, all possible positions of the distal oxygen were surveyed by rotating this oxygen about the single bond between the C4a and the proximal oxygen.	Oxygen	179-185	complement C4A (Rodgers blood group)	Homo sapiens	220-223
23962064-3	2014	Vascular endothelial growth factor (VEGF) preserves lung angiogenesis and alveolarization in experimental O2-induced arrested alveolar growth in newborn rats, but combined VEGF+angiopoietin 1 treatment is necessary to correct VEGF-induced vessel leakiness.	Oxygen	106-108	vascular endothelial growth factor A	Rattus norvegicus	0-34
2316714-3	1990	We found that EPO formation in mice exposed to normobaric hypoxia (8% O2) or to carbon monoxide (0.1%) was reduced by 30 and 42% when animals were simultaneously exposed to hypercapnia (7% CO2), by 35 and 38% when subjected to metabolic acidosis (NH4Cl), and unchanged when subjected to metabolic alkalosis (NaHCO3).	Oxygen	70-72	erythropoietin	Mus musculus	14-17
23962064-3	2014	Vascular endothelial growth factor (VEGF) preserves lung angiogenesis and alveolarization in experimental O2-induced arrested alveolar growth in newborn rats, but combined VEGF+angiopoietin 1 treatment is necessary to correct VEGF-induced vessel leakiness.	Oxygen	106-108	vascular endothelial growth factor A	Rattus norvegicus	36-40
23962064-3	2014	Vascular endothelial growth factor (VEGF) preserves lung angiogenesis and alveolarization in experimental O2-induced arrested alveolar growth in newborn rats, but combined VEGF+angiopoietin 1 treatment is necessary to correct VEGF-induced vessel leakiness.	Oxygen	106-108	angiopoietin 1	Rattus norvegicus	177-191
24389492-1	2014	Increased spontaneous locomotive activity and oxygen consumption have been reported in transgenic mice overexpressing leptin in the liver.	Oxygen	46-52	leptin	Mus musculus	118-124
2339104-0	1990	Applications of oxygen polarography to drug stability testing and formulation development: solution-phase oxidation of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.	Oxygen	16-22	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	119-171
2308933-4	1990	Scans of the upper surface of an elodea leaf in the dark and under irradiation, where the tip reaction is the reduction of oxygen produced by photosynthesis, demonstrate the possibility of obtaining information about the distribution of reaction sites on the substrate surface.	Oxygen	123-129	TOR signaling pathway regulator	Homo sapiens	90-93
34911392-0	2022	Implantation of bovine hydroxyapatite and secretome with different oxygen concentration may improve massive bone defect regeneration: An experimental study on animal model.	Oxygen	67-73	secreted protein acidic and cysteine rich	Bos taurus	156-158
25140303-1	2014	In response to low oxygen supply, cancer cells elevate production of HIF-1alpha, a hypoxia-inducible transcription factor that subsequently acts to stimulate blood vessel formation and promote survival.	Oxygen	19-25	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-79
34115146-1	2022	PURPOSE: This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma.	Oxygen	186-192	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	245-248
2356363-1	1990	A 3-dimensional analytical model of O2 diffusion in heavily working muscle is proposed which considers anisotropic, myoglobin (Mb)-facilitated O2 diffusion inside the muscle fiber and a carrier-free layer separating erythrocytes and fiber.	Oxygen	36-38	myoglobin	Homo sapiens	116-125
2356363-1	1990	A 3-dimensional analytical model of O2 diffusion in heavily working muscle is proposed which considers anisotropic, myoglobin (Mb)-facilitated O2 diffusion inside the muscle fiber and a carrier-free layer separating erythrocytes and fiber.	Oxygen	143-145	myoglobin	Homo sapiens	116-125
34929449-8	2022	The peritoneal macrophages isolated from ghsr-/- mice exhibited lower levels of cytokines production and oxygen consumption rate after LPS stimulation.	Oxygen	105-111	growth hormone secretagogue receptor	Mus musculus	41-45
25276815-6	2014	We found that PMCA2-downregulated cells showed higher basal O2 consumption, lower NAD(P)H level, and increased activity of ETC.	Oxygen	60-62	ATPase plasma membrane Ca2+ transporting 2	Rattus norvegicus	14-19
34940908-9	2022	(5) The roles of free versus myoglobin-facilitated O2 diffusion.	Oxygen	51-53	myoglobin	Homo sapiens	29-38
2155167-0	1990	Purine nucleoside phosphorylase: a new marker for free oxygen radical injury to the endothelial cell.	Oxygen	55-61	purine nucleoside phosphorylase	Rattus norvegicus	0-31
25095893-2	2014	We intended to develop cardiomyocytes (CMs) expressing the oxygen-dependent degradation domain of HIF-1alpha fused to the firefly luciferase (ODD-Luc) followed by proof-of-concept for its applicability in the assessment of heart muscle oxygenation.	Oxygen	59-65	hypoxia inducible factor 1, alpha subunit	Mus musculus	98-108
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	100-119
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	120-130
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	356-366
34908510-5	2022	EXPERT OPINION: Several mechanisms could contribute to improved renal prognosis with SGLT2is, among which a reduction in intraglomerular pressure by restoring the tubuloglomerular feedback, a diuretic effect that contributes to lower albuminuria and renal decongestion, especially if fluid overload is present, a reduction in renal oxygen consumption, an improvement of heart failure status with less cardiorenal syndrome and a lower risk of acute renal injury.	Oxygen	332-338	solute carrier family 5 member 2	Homo sapiens	85-90
34371428-4	2022	Firstly, GOx convert the high levels of glucose in the tumor to hydrogen peroxide (H2O2), and then IrO2 NPs convert H2O2 to oxygen (O2), which can enhance the type II of PDT.	Oxygen	124-130	hydroxyacid oxidase 1, liver	Mus musculus	9-12
34371428-4	2022	Firstly, GOx convert the high levels of glucose in the tumor to hydrogen peroxide (H2O2), and then IrO2 NPs convert H2O2 to oxygen (O2), which can enhance the type II of PDT.	Oxygen	132-134	hydroxyacid oxidase 1, liver	Mus musculus	9-12
1968295-3	1990	In nine 7-day-old rats, an acute focal hypoxic-ischemic insult produced by unilateral carotid artery ligation and subsequent exposure to 8% oxygen acutely reduced 3H-TCP binding ipsilateral to the ligation by 30% in the CA1, by 27% in the CA3, by 26% in the dentate gyrus, and by 17% in the striatum compared with values from the contralateral hemisphere.	Oxygen	140-146	carbonic anhydrase 1	Rattus norvegicus	220-223
2092960-5	1990	Analysis of calculated charge distribution reveals that the negative charges are localized on the ring nitrogen and on the exocyclic oxygen atoms of A10 and are similar to the corresponding charges computed for some pyrimidine bases.	Oxygen	133-139	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	149-152
34969976-5	2022	Arg403 in the pore helix of CNGB3 projects into an asymmetric selectivity filter and forms hydrogen bonds with two pore-lining backbone carbonyl oxygens.	Oxygen	145-152	cyclic nucleotide gated channel subunit beta 3	Homo sapiens	28-33
25323790-9	2014	CONCLUSION: Inhibition of HIF-2alpha protein reversed lipid metabolism dysregulation induced by acute hypoxia in HepG2 cells, which suggested that HIF-2alpha signaling may be relevant to oxygen-dependent lipid homeostasis in the liver.	Oxygen	187-193	endothelial PAS domain protein 1	Homo sapiens	147-157
24166374-2	2014	Recently a mouse model was generated in which a chimeric protein consisting of HIF-1alpha oxygen-dependent degradation domain (ODD) fused to luciferase was ubiquitously expressed in all tissues.	Oxygen	90-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	79-89
34894941-4	2021	METHODS: We used human retinal vascular endothelial cells (HRECs) and oxygen-induced retinopathy (OIR) mice model to show ANXA2 can promote the development of RNV through PI3K/AKT signaling pathway.	Oxygen	70-76	annexin A2	Mus musculus	122-127
33821889-1	2021	To inculcate biocatalytic activity in the oxygen-storage protein myoglobin (Mb), a genetically engineered myoglobin mutant H64DOPA (DOPA = L-3,4-dihydroxyphenylalanine) has been created.	Oxygen	42-48	myoglobin	Homo sapiens	65-74
33821889-1	2021	To inculcate biocatalytic activity in the oxygen-storage protein myoglobin (Mb), a genetically engineered myoglobin mutant H64DOPA (DOPA = L-3,4-dihydroxyphenylalanine) has been created.	Oxygen	42-48	myoglobin	Homo sapiens	76-78
33821889-1	2021	To inculcate biocatalytic activity in the oxygen-storage protein myoglobin (Mb), a genetically engineered myoglobin mutant H64DOPA (DOPA = L-3,4-dihydroxyphenylalanine) has been created.	Oxygen	42-48	myoglobin	Homo sapiens	106-115
34987704-10	2021	Jun was found to be associated with hypoxia in endothelial cells, whereas Irf9 and Etv5 were identified as astrocyte-specific TFs associated with oxygen concentration in the mouse cerebral cortex.	Oxygen	146-152	interferon regulatory factor 9	Mus musculus	74-78
25535647-2	2014	With hypoxic stress, vascular endothelial growth factor (VEGF) is a signal protein produced by cells and further contributes to improvement of vascular functions and restoring the oxygen supply to tissues.	Oxygen	180-186	vascular endothelial growth factor A	Rattus norvegicus	21-55
33767374-7	2022	APN-deficient (APN-/-) newborn mice exposed to moderate (60% O2) hyperoxia showed a worse BPD pulmonary phenotype (inflammation, enhanced endothelial dysfunction, impaired pulmonary vasculature, and alveolar simplification) as compared to wild-type (WT) mice.	Oxygen	61-63	adiponectin, C1Q and collagen domain containing	Mus musculus	0-3
33804598-3	2021	We attested hypoxic cells by a transgenic reporter approach under the ubiquitous CAG promoter, with Hif-1alpha oxygen-dependent degradation-domain (ODD) fused to CreERT2-recombinase.	Oxygen	111-117	hypoxia inducible factor 1, alpha subunit	Mus musculus	100-110
34977450-3	2021	Catalase in peroxisomes plays an important role in this process by disproportionating H2O2 resulting from glycolate oxidation into O2 and water.	Oxygen	131-133	catalase 2	Arabidopsis thaliana	0-8
25535647-2	2014	With hypoxic stress, vascular endothelial growth factor (VEGF) is a signal protein produced by cells and further contributes to improvement of vascular functions and restoring the oxygen supply to tissues.	Oxygen	180-186	vascular endothelial growth factor A	Rattus norvegicus	57-61
25535647-6	2014	Our results demonstrated that hypoxic stress induced by exposure of lower O(2) (6 h) significantly increased the levels of HIF-1alpha and VEGF in the oxidative and glycolytic muscles of SD rats and pikas (P&lt;0.05 vs. normoxic conditions).	Oxygen	74-78	vascular endothelial growth factor A	Rattus norvegicus	138-142
34943374-4	2021	This acute hypo-insulinemia may result from a disruption in chloride balance in beta-cells arising from an imbalanced KCC2-NKCC1 (chloride exporter-importer) density as a consequence of periodic oxygen desaturation.	Oxygen	195-201	solute carrier family 12 member 5	Rattus norvegicus	118-122
33768186-10	2021	However, circulating levels of miR-181c and miR-484 on the 7th day showed significant positive correlations with the anaerobic threshold and peak oxygen consumption from CPET analysis.	Oxygen	146-152	microRNA 484	Homo sapiens	44-51
24183749-0	2014	Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats.	Oxygen	80-86	vascular endothelial growth factor A	Rattus norvegicus	10-14
33032209-3	2021	Although thermal treatment at <= 600  C did not lead to the collapse of zeolite framework, it removed H2O molecules from the coordination shell of extraframework Co2+, which in turn changed its coordination structure in a way to strengthen the interaction between Co2+ and the lattice oxygens.	Oxygen	285-292	complement C2	Homo sapiens	162-165
33032209-3	2021	Although thermal treatment at <= 600  C did not lead to the collapse of zeolite framework, it removed H2O molecules from the coordination shell of extraframework Co2+, which in turn changed its coordination structure in a way to strengthen the interaction between Co2+ and the lattice oxygens.	Oxygen	285-292	complement C2	Homo sapiens	264-267
34943374-5	2021	Mechanistically, we postulate that a reduced insulin secretion due to the KCC2-NKCC1 imbalance subsequent to acute oxygen desaturation could result in hyperglycemia in rat pups, paralleling symptoms shown in patients with COVID-19 who experienced acute respiratory distress.	Oxygen	115-121	solute carrier family 12 member 5	Rattus norvegicus	74-78
34821220-7	2021	SREBP1 overexpression significantly increased the oxygen consumption rate, filopodia formation, and migratory and invasive capacities of thyroid cancer cells.	Oxygen	50-56	sterol regulatory element binding transcription factor 1	Homo sapiens	0-6
24251695-9	2013	MEASUREMENTS AND MAIN RESULTS: Only TRPC1 mRNA was up-regulated under hypoxia in isolated murine PASMC (1% O2 for 72 h).	Oxygen	107-109	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	36-41
34863080-12	2021	As a result, puerarin hindered glucose uptake and metabolism by downregulating the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) dependent upon HIF-1alpha and glucose transporter GLUT1.	Oxygen	83-89	hypoxia inducible factor 1, alpha subunit	Mus musculus	176-186
34863080-12	2021	As a result, puerarin hindered glucose uptake and metabolism by downregulating the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) dependent upon HIF-1alpha and glucose transporter GLUT1.	Oxygen	83-89	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	211-216
33427520-1	2021	Endostatin (ES) can effectively inhibit neovascularization in most solid tumors and has the potential to make oxygen delivery more efficient and increase the efficacy of radiotherapy (RT).	Oxygen	110-116	collagen type XVIII alpha 1 chain	Homo sapiens	0-10
33814763-12	2021	Based on ROC analysis a score of 4 for OS1, 9 for OS2 and 12.7% for OP was determined as the cut off for oxygen requirement.	Oxygen	105-111	matrilin 3	Homo sapiens	50-53
25573745-5	2015	Acute CPT1A inhibition reduces cellular ATP levels and oxygen consumption, which are restored by replenishing the tricarboxylic acid cycle.	Oxygen	55-61	carnitine palmitoyltransferase 1A	Rattus norvegicus	6-11
24155240-6	2013	Additionally, mitochondrial mass and number as well as oxygen consumption are elevated upon Nat8l overexpression.	Oxygen	55-61	N-acetyltransferase 8-like	Mus musculus	92-97
18823885-12	2009	With use of logistic regression, the addition of oxygen, intraperitoneal pressure, and ventilation were found to be independent variables affecting Pco(2), pH, ABE, SBE, HCO(3)(-), O(2)Hb, So(2), p50, and end-tidal CO(2).	Oxygen	49-55	Y-box-binding protein 1	Oryctolagus cuniculus	196-199
34979607-9	2021	The posterior probability of the oxygen requirement on the REGN-COV2 group was 18% (95% CrI: 3 - 33%), compared with the control of 36% (95% CrI: 16 - 54%).	Oxygen	33-39	regn-cov2	None	59-68
34799994-5	2021	Furthermore, we found that the level of TET2 was decreased in the nucleus when beta2SP was knocked out after oxygen and glucose deprivation (OGD), and the level of 5hmC was reduced in the OGD+beta2SP KO group.	Oxygen	109-115	tet methylcytosine dioxygenase 2	Mus musculus	40-44
24349272-6	2013	Mitochondrial fractions isolated from liver, brain and skeletal muscle by anti-TOM22 magnetic beads showed oxygen consumption capacities comparable to previously reported values and little contamination with other organelles.	Oxygen	107-113	translocase of outer mitochondrial membrane 22	Mus musculus	79-84
19900406-1	2010	Upregulated gene 11 (URG11), recently identified as a new HBx-upregulated gene that may activate beta-catenin and Wnt signaling, was found to be upregulated in a human tubule cell line under low oxygen.	Oxygen	195-201	catenin beta 1	Homo sapiens	97-109
24316858-10	2013	The genes that were up regulated in the oxygen carriers cluster (12 genes) were: Hbq1, Mb, Ngb, Slc38a1 and Xirp1.	Oxygen	40-46	xin actin-binding repeat containing 1	Mus musculus	108-113
34836778-7	2022	The docking model of sitafloxacin and topoisomerase IV showed that the oxygen atom at the gamma position of Serine 83 of ParC interacted with the sitafloxacin carboxylate moiety.	Oxygen	71-77	cullin 9	Homo sapiens	121-125
34648659-5	2022	Proteomics analysis indicated GILT inhibited reactive oxygen species and autophagy activation in breast cancer cells, and GILT overexpression-mediated tumor growth was further enhanced in the presence of autophagy or reactive oxygen species inhibitors.	Oxygen	54-60	interferon gamma inducible protein 30	Mus musculus	30-34
24047466-4	2013	In PASMCs from Sirt3 knockout (Sirt3(-/-)) mice in the C57BL/6 background, we observed that acute hypoxia (1.5% O2; 30 min)-induced changes in ROS signaling, detected using targeted redox-sensitive, ratiometric fluorescent protein sensors (roGFP) in the mitochondrial matrix, intermembrane space, and the cytosol, were indistinguishable from Sirt3(+/+) cells.	Oxygen	112-114	sirtuin 3	Mus musculus	15-20
34648659-5	2022	Proteomics analysis indicated GILT inhibited reactive oxygen species and autophagy activation in breast cancer cells, and GILT overexpression-mediated tumor growth was further enhanced in the presence of autophagy or reactive oxygen species inhibitors.	Oxygen	226-232	interferon gamma inducible protein 30	Mus musculus	30-34
34648659-5	2022	Proteomics analysis indicated GILT inhibited reactive oxygen species and autophagy activation in breast cancer cells, and GILT overexpression-mediated tumor growth was further enhanced in the presence of autophagy or reactive oxygen species inhibitors.	Oxygen	226-232	interferon gamma inducible protein 30	Mus musculus	122-126
24047466-6	2013	During sustained hypoxia (1.5% O2; 16 h), Sirt3 deletion augmented mitochondrial matrix oxidant stress, but this did not correspond to an augmentation of intermembrane space or cytosolic oxidant signaling.	Oxygen	31-33	sirtuin 3	Mus musculus	42-47
24123253-1	2013	Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain.	Oxygen	102-108	CCAAT enhancer binding protein zeta	Homo sapiens	85-88
34736179-4	2022	In this work, combustion behaviors of OPS/ADP/PA6 were investigated by limited oxygen index (LOI), UL94 and cone calorimeter (CONE) tests.	Oxygen	79-85	WD and tetratricopeptide repeats 1	Homo sapiens	42-49
34878944-2	2022	Previous studies indicate that TGFbeta activation in the O2-injured mouse pup lung increases lysyl oxidase (LOX) expression.	Oxygen	57-59	transforming growth factor alpha	Mus musculus	31-38
34878944-4	2022	First, we determined that O2-mediated lung injury increases LOX protein expression in TGFbeta-stimulated pup lung interstitial fibroblasts.	Oxygen	26-28	transforming growth factor alpha	Mus musculus	86-93
23489195-7	2013	SlNAC1 overexpression increased the chilling tolerance of tomato plants by maintaining the higher maximal photochemical efficiency of photosystem II and oxygen-evolving activities.	Oxygen	153-159	NAC domain protein	Solanum lycopersicum	0-6
34837397-3	2022	In this study, we found that the mRNA and protein expression levels of TBC1D25 decreased in mouse brain after I/R injury and primary cortical neurons treated with oxygen and glucose deprivation/reoxygenation (OGD/R).	Oxygen	163-169	TBC1 domain family, member 25	Mus musculus	71-78
34863041-8	2022	Since oxygen regulated stability of hypoxia-inducible transcription factors relevant for EPO expression is dependent on the activity of prolyl-4-hydroxylases (PHD) 2 and 3, this study aimed to determine the relevance of different PHD isoforms for the EPO expression in renin producing cells in vivo.	Oxygen	6-12	erythropoietin	Mus musculus	89-92
34863041-8	2022	Since oxygen regulated stability of hypoxia-inducible transcription factors relevant for EPO expression is dependent on the activity of prolyl-4-hydroxylases (PHD) 2 and 3, this study aimed to determine the relevance of different PHD isoforms for the EPO expression in renin producing cells in vivo.	Oxygen	6-12	erythropoietin	Mus musculus	251-254
24264835-3	2013	The GR-CdS-TiO2 composites are able to serve as a highly selective visible-light-driven photocatalyst for oxidation of saturated primary C-H bonds using benign oxygen as oxidant under ambient conditions.	Oxygen	160-166	CDP-diacylglycerol synthase 1	Homo sapiens	7-10
34736839-10	2022	RC ground TB had greater oxygen consumption and lower thiobarbituric acid reactive substances compared to CN.	Oxygen	25-31	regucalcin	Bos taurus	0-2
23994690-0	2013	Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1.	Oxygen	83-89	slit guidance ligand 2	Homo sapiens	141-146
34890065-3	2022	Thanks to the strong singlet oxygen generation ability, Ru2 could photo-inactivate S. aureus and MRSA effectively and specifically.	Oxygen	29-35	doublecortin domain containing 2	Homo sapiens	56-59
34668435-4	2022	NPR-C expression was highest at 5% O2, while being suppressed by 21% O2, in cultured mouse lung epithelial cells (MLE-15s) and/or human primary AEC2s.	Oxygen	35-37	natriuretic peptide receptor 3	Mus musculus	0-5
34668435-4	2022	NPR-C expression was highest at 5% O2, while being suppressed by 21% O2, in cultured mouse lung epithelial cells (MLE-15s) and/or human primary AEC2s.	Oxygen	69-71	natriuretic peptide receptor 3	Mus musculus	0-5
34668435-8	2022	These data suggest that elevated O2 downregulates AEC2 NPR-C, and that steroid-mediated NPR-C downregulation in neonatal lungs may provide a novel mechanism for their effect on perinatal surfactant production.	Oxygen	33-35	natriuretic peptide receptor 3	Mus musculus	55-60
34658125-3	2022	The hypoxia inducible factor 1-alpha (HIF-1alpha), as a transcription factor, can regulate the cellular adaptation to low oxygen levels and support the development and function of the gut barrier.	Oxygen	122-128	hypoxia inducible factor 1, alpha subunit	Mus musculus	4-36
23999071-8	2013	Reoxygenation with 100% oxygen after hypoxia uniquely upregulated Gadd45g, Dusp1, Peg3, and Tgm2.	Oxygen	2-8	transglutaminase 2, C polypeptide	Mus musculus	92-96
34658125-3	2022	The hypoxia inducible factor 1-alpha (HIF-1alpha), as a transcription factor, can regulate the cellular adaptation to low oxygen levels and support the development and function of the gut barrier.	Oxygen	122-128	hypoxia inducible factor 1, alpha subunit	Mus musculus	38-48
34742454-2	2022	In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor.	Oxygen	186-192	CD274 molecule	Homo sapiens	275-280
24091830-2	2013	Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 20 C in highly oligotrophic and oxygen-limited waters.	Oxygen	186-192	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
34437764-4	2022	We have investigated whether the oxygen consumption rate (OCR) of peripheral blood mononuclear cells (PBMCs) obtained from patients with MCAD, VLCAD, and CUD can be used to study cellular metabolism in patients with FAO defects and to determine the severity of FAO impairment.	Oxygen	33-39	acyl-CoA dehydrogenase very long chain	Homo sapiens	143-148
23912262-0	2013	Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.	Oxygen	60-66	sirtuin 1	Mus musculus	9-17
34606743-5	2022	In vitro, HIF1alpha is required for basal and cAMP-induced STAR expression, under ambient and reduced oxygen (O2) tension.	Oxygen	102-108	hypoxia inducible factor 1, alpha subunit	Mus musculus	10-19
34606743-5	2022	In vitro, HIF1alpha is required for basal and cAMP-induced STAR expression, under ambient and reduced oxygen (O2) tension.	Oxygen	110-112	hypoxia inducible factor 1, alpha subunit	Mus musculus	10-19
23912262-4	2013	In this study we aim to investigate the potential role of Sirtuin 1 (Sirt1), a metabolically-regulated protein deacetylase, in mediating the response of ischemic neurons to regulate vascular regrowth in a mouse model of oxygen-induced ischemic retinopathy (OIR).	Oxygen	220-226	sirtuin 1	Mus musculus	58-67
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	steroidogenic acute regulatory protein	Mus musculus	48-52
23912262-4	2013	In this study we aim to investigate the potential role of Sirtuin 1 (Sirt1), a metabolically-regulated protein deacetylase, in mediating the response of ischemic neurons to regulate vascular regrowth in a mouse model of oxygen-induced ischemic retinopathy (OIR).	Oxygen	220-226	sirtuin 1	Mus musculus	69-74
24286519-11	2013	In addition, CD56+ monocytes spontaneously produced more reactive oxygen intermediates than CD56- monocytes.	Oxygen	66-72	neural cell adhesion molecule 1	Homo sapiens	13-17
34863940-8	2022	Likewise, HFD significantly increased URAT1 expression in BAT, resulting in the lipid accumulation (whitening of BAT) and increased production of tissue reactive oxygen species, which were reduced by dotinurad via UCP1 activation.	Oxygen	162-168	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	38-43
24157153-0	2013	Hyperbaric oxygen intervention on expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in spinal cord injury models in rats.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	84-118
34965440-5	2021	Thus, KSHV regulation of the oxygen-sensing machinery allows virally infected cells to initiate translation via the mTOR-dependent eIF4E1 or the HIF2alpha-dependent, mTOR-independent, eIF4E2.	Oxygen	29-35	endothelial PAS domain protein 1	Homo sapiens	145-154
34965440-5	2021	Thus, KSHV regulation of the oxygen-sensing machinery allows virally infected cells to initiate translation via the mTOR-dependent eIF4E1 or the HIF2alpha-dependent, mTOR-independent, eIF4E2.	Oxygen	29-35	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	184-190
34959014-7	2021	The underlying adsorption mechanisms for Cd2+ and Pb2+ on fresh biochar were dominated by coprecipitation, cation exchange and cation-pi interaction, whereas surface complexation and cation exchange appeared to be more vital for aged biochar, as more active adsorption sites and Oxygen-containing functional groups were formed on its surface during aging, which was well explained by BET, XPS, FTIR and Elemental Analysis.	Oxygen	279-285	CD2 molecule	Homo sapiens	41-44
23716564-1	2013	Hypoxia-inducible factor 2alpha (HIF-2alpha) plays a pivotal role in the balancing of oxygen requirements throughout the body.	Oxygen	86-92	endothelial PAS domain protein 1	Homo sapiens	0-31
34890531-1	2021	AbstractThis work aimed to produce low-oxygen bio-oil through the co-pyrolysis of biogas residue (BR) with polyethylene (PE) and polypropylene (PP).	Oxygen	39-45	chromosome 12 open reading frame 73	Homo sapiens	98-100
23716564-1	2013	Hypoxia-inducible factor 2alpha (HIF-2alpha) plays a pivotal role in the balancing of oxygen requirements throughout the body.	Oxygen	86-92	endothelial PAS domain protein 1	Homo sapiens	33-43
24640101-5	2013	The activated beta-catenin regulates the expression of genes of the cell response to hypoxia and thus, it maintains the growth of breast cancer in the reduced oxygen conditions.	Oxygen	159-165	catenin beta 1	Homo sapiens	14-26
34941793-11	2021	Lung CD4+CD25+ T cells and BALF IL17a correlated directly with BALF total protein and inversely with rat oxygen saturations.	Oxygen	105-111	interleukin 17A	Rattus norvegicus	32-37
34923938-12	2021	Inhibition of TrxR results in a decrease of thiols content and total glutathione elevates reactive oxygen species levels, and finally promotes oxidative stress-mediated apoptosis of cancer cells.	Oxygen	99-105	peroxiredoxin 5	Homo sapiens	14-18
34763176-9	2021	Patients with long term oxygen therapy and severe exercise dyspnea were most likely to remain non-responders to repeated PR.	Oxygen	24-30	transmembrane protein 37	Homo sapiens	121-123
34871543-7	2021	The main findings indicated gradually increasing PHD2 under lowered O2.	Oxygen	68-70	egl-9 family hypoxia-inducible factor 1	Mus musculus	49-53
34823575-9	2021	Ex vivo, differentiation of osteoblasts was inhibited upon Pink1 downregulation, accompanied by impaired mitochondrial homeostasis, increased mitochondrial reactive oxygen species production, and defects in mitochondrial calcium handling.	Oxygen	165-171	PTEN induced putative kinase 1	Mus musculus	59-64
34910838-3	2022	Herein, we report on the first effort to design a convenient tumor-specific A2AR inhibition strategy to improve antitumor immune responses via the spatiotemporally controlled oxygen supply by virtue of a versatile photo-modulated nanoreactor.	Oxygen	175-181	adenosine A2a receptor	Homo sapiens	76-80
23832611-5	2013	An ex1/ex2/flu mutant accumulates in the dark Pchlide and upon illumination generates similar amounts of (1)O2 as flu, but (1)O2-mediated responses are abrogated in the triple mutant.	Oxygen	105-110	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	7-10
34812811-5	2021	CoP-CNT/Ni2P/NF performs better in the oxygen evolution reaction (eta50 = 301 mV), benefiting mainly from its improved electrochemically active surface area.	Oxygen	39-45	caspase recruitment domain family member 16	Homo sapiens	0-3
34661337-8	2021	Tet2/3 cooperatively induces Prdm1 expression via oxygen-dependent DNA demethylation, which in turn activates NFATc1 required for osteoclastogenesis.	Oxygen	50-56	tet methylcytosine dioxygenase 2	Mus musculus	0-6
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Oxygen	88-94	Alternative oxidase family protein	Arabidopsis thaliana	0-24
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Oxygen	88-94	Alternative oxidase family protein	Arabidopsis thaliana	26-30
24086512-9	2013	We also showed that HDAC4 levels correlated positively with maximum oxygen consumption (VO2 Max) but negatively with body mass index, percent body fat, and the inflammatory chemokine RANTES.	Oxygen	68-74	histone deacetylase 4	Homo sapiens	20-25
34709261-4	2021	The lowest WVTR value measured was 1.28 x 10-5 g m-2 day-1 for the O2 plasma pre-treated PEN substrate coated with 100 ALI cycles, which improved 3-4 orders of magnitude compared to that of the pristine ones.	Oxygen	67-69	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	89-92
34709261-5	2021	Besides, the infiltrated PEN substrate with O2 plasma pre-treatment exhibited good mechanical stability, with only a slight increase of the WVTR value which was observed after the bending fatigue test with a radius of 5 mm.	Oxygen	44-46	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	25-28
34601811-7	2021	Furthermore, the oxygen scavenging effect created by Mn3 O4 nanorods was successfully applied to a mouse model of PD; the amount of alpha-synuclein (alpha-syn) in the cerebrospinal fluid of PD mice was reduced by 61.2% in two weeks, thus demonstrating the potential application of facet-directed Mn3 O4 NPs for the clinical therapy of neurodegenerative disease.	Oxygen	17-23	synuclein, alpha	Mus musculus	132-147
34601811-7	2021	Furthermore, the oxygen scavenging effect created by Mn3 O4 nanorods was successfully applied to a mouse model of PD; the amount of alpha-synuclein (alpha-syn) in the cerebrospinal fluid of PD mice was reduced by 61.2% in two weeks, thus demonstrating the potential application of facet-directed Mn3 O4 NPs for the clinical therapy of neurodegenerative disease.	Oxygen	17-23	synuclein, alpha	Mus musculus	149-158
24040163-12	2013	1% O2 induced F-actin reorganization, increase of Hif-1alpha, vimentin and alpha-SMA in HSC-T6 cells.	Oxygen	3-5	hypoxia inducible factor 1, alpha subunit	Mus musculus	50-60
34506261-0	2021	Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.	Oxygen	24-30	microRNA 21	Homo sapiens	64-70
34506261-0	2021	Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.	Oxygen	24-30	phosphatase and tensin homolog	Homo sapiens	86-90
34828399-5	2021	The EPAS1 expression, stability, and activity are tightly regulated on several OMICs levels to maintain complex oxygen homeostasis.	Oxygen	112-118	endothelial PAS domain protein 1	Homo sapiens	4-9
23959876-4	2013	Using the oxygen-induced retinopathy mouse model for ischemic retinopathy, we provide evidence showing that hypoxic Muller cells promote vascular permeability by stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) and secreting angiogenic cytokines.	Oxygen	10-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	174-205
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Oxygen	159-165	NLR family, pyrin domain containing 3	Mus musculus	62-67
34653439-1	2021	Myoglobin is an essential transport protein of heart and muscle tissues that acts as a local oxygen reservoir and a marker in different diseased conditions.	Oxygen	93-99	myoglobin	Homo sapiens	0-9
23959876-4	2013	Using the oxygen-induced retinopathy mouse model for ischemic retinopathy, we provide evidence showing that hypoxic Muller cells promote vascular permeability by stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) and secreting angiogenic cytokines.	Oxygen	10-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	207-217
23959881-5	2013	Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy.	Oxygen	323-329	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	40-45
34617528-5	2021	After peritumoral injection of the oxygen-enriched composite hydrogel, the continuous supply of oxygen effectively relieved tumor hypoxia and down-regulated the expression of hypoxia-inducible factor-1alpha.	Oxygen	35-41	hypoxia inducible factor 1, alpha subunit	Mus musculus	175-206
34617528-5	2021	After peritumoral injection of the oxygen-enriched composite hydrogel, the continuous supply of oxygen effectively relieved tumor hypoxia and down-regulated the expression of hypoxia-inducible factor-1alpha.	Oxygen	96-102	hypoxia inducible factor 1, alpha subunit	Mus musculus	175-206
34783549-3	2021	In response, we have developed a series of bulky ligands, Ar3-TMPA (Ar = tpb, dpb, dtbpb), and used them to support copper(I) complexes that react with O2 to yield (CuII(eta1-O2 -)(Ar3-TMPA))+ species, which are stable against dimerization at all temperatures.	Oxygen	152-154	secreted phosphoprotein 1	Homo sapiens	170-174
24019872-9	2013	The over-expression of Hv-SGT1 in Yangmai 158 enhanced resistance to powdery mildew, and this correlated with increased levels of whole-cell reactive oxygen intermediates at the sites of penetration by the pathogens.	Oxygen	150-156	protein SGT1 homolog	Triticum aestivum	26-30
34216952-3	2021	The prepared catalyst exhibited superior catalytic activity towards oxygen reduction reaction (ORR) such as the more positive onset potential of 0.96 V, half-wave potential of 0.86 V and smaller Tafel slope of 67.9 mV dec-1, outperforming those of commercial Pt/C.	Oxygen	68-74	ret proto-oncogene	Homo sapiens	259-263
34473153-6	2021	Herein we demonstrate Ru1-catalyzed H2O2 disproportionation into O2 and H2O, exhibiting an 8,580-fold faster catalase TOF vs. peroxidase TOF, which is 89.2-fold greater than the highest value reported for a Mn-porphyin or -salen complex.	Oxygen	65-67	Scm like with four mbt domains 1	Homo sapiens	22-25
34740380-9	2021	In parallel, a reduction in AIM2 contributed to autophagy activation and mitigated oxygen-glucose deprivation and reperfusion (OGD-Rep)-induced inflammation.	Oxygen	83-89	absent in melanoma 2	Rattus norvegicus	28-32
34469858-0	2021	Continuous Diffusion of Oxygen Adjunct Therapy to Improve Scar Reduction after Cervicotomy - A Proof of Concept Randomized Controlled Trial.	Oxygen	24-30	ribosomal protein S4 X-linked	Homo sapiens	58-62
34469858-3	2021	This study examined the effectiveness of a novel Continuous Diffusion of Oxygen (CDO) dressing to reduce scar length post cervicotomy.	Oxygen	73-79	ribosomal protein S4 X-linked	Homo sapiens	105-109
23811199-9	2013	We concluded that low levels of oxygen consumption moderately activates the p53 pathway, and leads to cellular senescence, but that high levels of oxygen consumption hyperactivates the p53 pathway, which results in cell death in SOD1-deficient MEFs.	Oxygen	147-153	transformation related protein 53, pseudogene	Mus musculus	185-188
34436746-0	2021	Silencing of H19 alleviates oxygen-glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.	Oxygen	28-34	H19 imprinted maternally expressed transcript	Homo sapiens	13-16
34436746-0	2021	Silencing of H19 alleviates oxygen-glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.	Oxygen	28-34	BCL2 like 13	Homo sapiens	128-135
34727409-7	2022	Overexpression of miR-15a-3p repressed GPX4 through binding to the 3"-untranslated region of GPX4, resulting in increased reactive oxygen species level, intracellular Fe2+ level, and malondialdehyde accumulation in vitro and in vivo.	Oxygen	131-137	glutathione peroxidase 4	Homo sapiens	39-43
34727409-7	2022	Overexpression of miR-15a-3p repressed GPX4 through binding to the 3"-untranslated region of GPX4, resulting in increased reactive oxygen species level, intracellular Fe2+ level, and malondialdehyde accumulation in vitro and in vivo.	Oxygen	131-137	glutathione peroxidase 4	Homo sapiens	93-97
23534392-6	2013	The PVR decreased significantly from 5.0 +- 2.6 W to 2.8 +- 2.2 W (P = 0.0001) with a significant increase in the Qp:Qs ratio, from 3.2 +- 1.4 to 4.9 +- 2.4 (P = 0.0008), and the VTIpv increased significantly from 22.6 +- 4.7 cm to 28.1 +- 6.2 cm (P = 0.0002) after 100% oxygen inhalation.	Oxygen	271-277	PVR cell adhesion molecule	Homo sapiens	4-7
34670383-2	2021	Myoglobin (Mb) which can be served as O2 storage and delivery depot is present in muscles and cardiac myocytes.	Oxygen	38-40	myoglobin	Homo sapiens	0-9
34523745-0	2021	Hyperbaric Oxygen via Mediating SIRT1-Induced Deacetylation of HMGB1 Improved Cerebral Ischemia/Reperfusion injury.	Oxygen	11-17	sirtuin 1	Mus musculus	32-37
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	inositol-3-phosphate synthase 1	Homo sapiens	189-193
34869775-3	2021	Thus, altitude training is often employed to increase blood oxygen-carrying capacity to improve sea-level endurance performance.	Oxygen	60-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
23815140-8	2013	IGF-I-induced phosphorylation of insulin receptor substrate-1 (IRS-1) was attenuated in low oxygen conditions as well.	Oxygen	92-98	insulin receptor substrate 1	Homo sapiens	33-61
34818544-0	2021	Suppression of breast cancer progression by FBXL16 via oxygen-independent regulation of HIF1alpha stability.	Oxygen	55-61	F-box and leucine rich repeat protein 16	Homo sapiens	44-50
34332958-6	2021	Such changes were abolished in Cry-null mice and were independent from oxygen tension, oxygen saturation, or expression of hypoxia-inducible factor 2 alpha, indicating that circadian erythropoietin expression is transcriptionally regulated by CRY1 and CRY2.	Oxygen	71-77	erythropoietin	Mus musculus	183-197
34332958-6	2021	Such changes were abolished in Cry-null mice and were independent from oxygen tension, oxygen saturation, or expression of hypoxia-inducible factor 2 alpha, indicating that circadian erythropoietin expression is transcriptionally regulated by CRY1 and CRY2.	Oxygen	87-93	erythropoietin	Mus musculus	183-197
23815140-8	2013	IGF-I-induced phosphorylation of insulin receptor substrate-1 (IRS-1) was attenuated in low oxygen conditions as well.	Oxygen	92-98	insulin receptor substrate 1	Homo sapiens	63-68
23815140-11	2013	These findings indicate that low oxygen conditions inhibit IGF-I action by increasing IGFBP-1, especially phosphorylated IGFBP-1, which inhibits IGF-I action.	Oxygen	33-39	insulin like growth factor binding protein 1	Homo sapiens	86-93
34534628-11	2021	This cellular metabolism switch was in turn supported with a reduction in oxygen consumption rate upon BORIS expression.	Oxygen	74-80	CCCTC-binding factor like	Homo sapiens	103-108
34718354-1	2021	BACKGROUND: Anemia of prematurity is common in extremely preterm neonates, and oxygen exposure may participate to anemia by inhibiting erythropoietin secretion.	Oxygen	79-85	erythropoietin	Rattus norvegicus	135-149
23815140-11	2013	These findings indicate that low oxygen conditions inhibit IGF-I action by increasing IGFBP-1, especially phosphorylated IGFBP-1, which inhibits IGF-I action.	Oxygen	33-39	insulin like growth factor binding protein 1	Homo sapiens	121-128
23710929-0	2013	Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles.	Oxygen	15-21	myoglobin	Homo sapiens	74-83
34547902-2	2021	However, reperfusion of myocardium results in superoxide (O2 -) generation, which promotes eNOS glutathionylation that produces O2 - instead of NO.	Oxygen	128-132	nitric oxide synthase 3, endothelial cell	Mus musculus	91-95
34547902-4	2021	Objective: To determine whether SG-eNOS continues to produce O2 - in I/R for a prolonged period causing accentuated I/R injury or it undergoes a time-dependent degradation.	Oxygen	61-65	nitric oxide synthase 3, endothelial cell	Mus musculus	32-39
34547902-5	2021	Methods and Results: Since SG-eNOS produces significant O2 - instead of NO, we sought to determine the time-course of SG-eNOS levels in the HCAEC in hypoxia/reoxygenation (H/R) by western analysis and immunoprecipitation.	Oxygen	56-60	nitric oxide synthase 3, endothelial cell	Mus musculus	30-34
34868007-8	2021	Downregulation of two major transcriptional factors, early growth response gene (Egr)-2 and growth factor independence 1 (Gfi1), were identified to play a role in the exaggerated pro-inflammatory response of preterm MF to LPS insult after priming with 65% or 3% O2.	Oxygen	262-264	early growth response 2	Homo sapiens	53-87
23461812-4	2013	Peak oxygen uptake (VO2peak ) was predicted from PACER lap count according to latest FITNESSGRAM standards and categorized into "at-risk" and "no-risk" for metabolic syndrome.	Oxygen	5-11	LAP	Homo sapiens	55-58
34788765-2	2022	Accumulation may occur by increased synthesis or by decline in activity of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) which requires oxygen for activity.	Oxygen	159-165	arylsulfatase B	Homo sapiens	86-101
34788765-2	2022	Accumulation may occur by increased synthesis or by decline in activity of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) which requires oxygen for activity.	Oxygen	159-165	arylsulfatase B	Homo sapiens	103-107
34788765-2	2022	Accumulation may occur by increased synthesis or by decline in activity of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) which requires oxygen for activity.	Oxygen	159-165	arylsulfatase B	Homo sapiens	109-142
34570973-1	2021	(Or, "A Surface Conductivity Model of Gas Sensitivity in Metal Oxides Based on Variable Surface Oxygen Vacancy Concentration").	Oxygen	96-102	gastrin	Homo sapiens	38-41
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	dynamin 1 like	Homo sapiens	0-4
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	dynamin 1 like	Homo sapiens	106-110
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	mitochondrial fission factor	Homo sapiens	111-114
34753356-8	2021	The antioxidant activity of PaT-2, predicted by in silico analyses and confirmed by cell-based assays, might be relevant for the protection of the skin of P. azureus adults against increased O2 levels and UV exposure on land compared with aquatic environments.	Oxygen	191-193	solute carrier family 36 member 2	Homo sapiens	28-33
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	NLR family, pyrin domain containing 3	Mus musculus	248-253
24280356-10	2013	To extend our findings to another cancer type, we developed an Ets-1 knockdown breast cancer cell model, which displayed decreased glycolytic dependence and increased oxygen consumption following Ets-1 knockdown confirming our earlier findings.	Oxygen	167-173	ETS proto-oncogene 1, transcription factor	Homo sapiens	63-68
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Oxygen	292-298	serine hydroxymethyltransferase 1	Homo sapiens	98-102
34697618-6	2021	This O2 can not only further improve the catalytic efficiency of GOX, but also provide raw materials for the production of ROS in PDT, which can effectively destroy the mitochondria of cancer cells, thereby causing tumor cell apoptosis.	Oxygen	5-7	hydroxyacid oxidase 1, liver	Mus musculus	65-68
34656615-5	2022	PLCgamma2 was required for the tissue infiltration of neutrophils, eosinophils and monocytes/macrophages, as well as for the accumulation of proinflammatory mediators (including IL-1beta, MIP-2 and LTB4) and reactive oxygen species.	Oxygen	217-223	phospholipase C, gamma 2	Mus musculus	0-9
34656615-6	2022	Mechanistic experiments revealed a role for PLCgamma2 in the release of proinflammatory mediators and reactive oxygen species but not in the intrinsic migratory capacity of leukocytes.	Oxygen	111-117	phospholipase C, gamma 2	Mus musculus	44-53
23696640-0	2013	alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.	Oxygen	123-129	alpha hemoglobin stabilizing protein	Homo sapiens	0-36
34460925-3	2021	OBJECTIVE: To assess differences in the acute effect of LFS vs HFS in ANT DBS utilizing blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI).	Oxygen	94-100	solute carrier family 25 member 6	Homo sapiens	70-73
34494990-0	2021	Hyperbaric oxygen therapy improves neurological function via the p38-MAPK/CCL2 signaling pathway following traumatic brain injury.	Oxygen	11-17	C-C motif chemokine ligand 2	Rattus norvegicus	74-78
34728640-0	2021	Light oxygen isotopes in mantle-derived magmas reflect assimilation of sub-continental lithospheric mantle material.	Oxygen	6-12	presequence translocase associated motor 16	Homo sapiens	40-46
34469714-0	2021	Competing endogenous RNA network associated with oxygen-induced retinopathy: expression of the network and identification of the MALAT1/miR-124-3p/EGR1 regulatory axis.	Oxygen	49-55	early growth response 1	Mus musculus	147-151
23696640-0	2013	alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.	Oxygen	123-129	alpha hemoglobin stabilizing protein	Homo sapiens	38-42
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Oxygen	166-168	alpha hemoglobin stabilizing protein	Homo sapiens	108-112
34617821-1	2021	Critical power (CP) delineates the heavy and severe exercise intensity domains, and sustained work rates above CP result in an inexorable progression of oxygen uptake to a maximal value and, subsequently, the limit of exercise tolerance.	Oxygen	153-159	ceruloplasmin	Homo sapiens	16-18
34617821-1	2021	Critical power (CP) delineates the heavy and severe exercise intensity domains, and sustained work rates above CP result in an inexorable progression of oxygen uptake to a maximal value and, subsequently, the limit of exercise tolerance.	Oxygen	153-159	ceruloplasmin	Homo sapiens	111-113
34626018-0	2021	Atomically Dispersed Co2 -N6 and Fe-N4 Costructures Boost Oxygen Reduction Reaction in Both Alkaline and Acidic Media.	Oxygen	58-64	complement C2	Homo sapiens	21-24
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Oxygen	166-168	alpha hemoglobin stabilizing protein	Homo sapiens	208-212
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Oxygen	231-233	alpha hemoglobin stabilizing protein	Homo sapiens	108-112
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Oxygen	231-233	alpha hemoglobin stabilizing protein	Homo sapiens	208-212
23673340-7	2013	Expanding roles for MYC, PI3K and TP53 in regulating reactive oxygen production, glycolysis and glutaminolysis in lymphoma cells have been described.	Oxygen	62-68	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	20-23
34558885-0	2021	Diallyl Trisulfide Suppresses High-Glucose-Induced Cardiomyocyte Apoptosis by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1alpha/Insulin-like Growth Factor Binding Protein 3 Activation.	Oxygen	97-103	insulin like growth factor binding protein 3	Homo sapiens	153-197
34610308-4	2021	Here, we report that loss of PHD2/3, the cellular oxygen sensors, blocks LCFA mitochondria uptake and beta-oxidation in cardiomyocytes.	Oxygen	50-56	egl-9 family hypoxia-inducible factor 1	Mus musculus	29-35
34583520-9	2021	Transverse aortic constriction-related reactive oxygen species formation resulted in RIalpha oxidation in WT but not in KI mice.	Oxygen	48-54	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	85-92
34481123-9	2021	CONCLUSION: These results provide evidence that LTBP3, via TGFbeta2, plays an important role in promoting brown adipogenesis by modulating UCP1 expression and mitochondrial oxygen consumption.	Oxygen	173-179	latent transforming growth factor beta binding protein 3	Homo sapiens	48-53
34482201-4	2021	Moreover, conditional ablation of Wdfy4 in T cells enhanced the apoptosis of CD8+ T cells and increased the intracellular levels of reactive oxygen species accompanied by the upregulation of Nox2.	Oxygen	141-147	WD repeat and FYVE domain containing 4	Mus musculus	34-39
34487922-3	2021	Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27.	Oxygen	136-142	cytokine like 1	Homo sapiens	111-115
34487922-3	2021	Meanwhile, the oxidation of C-18 methyl to carboxyl group forms a 18,20-lactone, and the oxidation of C-14 and C-17 gets a heterocyclic oxygen acrossing rings C and D. Additionly, physalins frequently form an oxygen bridge to connect C-14 to C-27.	Oxygen	209-215	cytokine like 1	Homo sapiens	111-115
34547902-2	2021	However, reperfusion of myocardium results in superoxide (O2 -) generation, which promotes eNOS glutathionylation that produces O2 - instead of NO.	Oxygen	58-62	nitric oxide synthase 3, endothelial cell	Mus musculus	91-95
34829785-1	2021	The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food.	Oxygen	137-143	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	9-12
34323115-4	2021	Here we reported that when infected with IAV, 40x8 mice display an early transient activation of TGFbeta signaling and later airway hyperreactivity associated with peribronchial inflammation (profibrotic macrophages) and fibrosis compared to infected room air controls, suggesting neonatal oxygen induced hidden molecular changes that prime the lung for hyperreactive airways disease.	Oxygen	290-296	transforming growth factor alpha	Mus musculus	97-104
24353656-2	2013	Relative hypoxemia with increasing altitude above sea level exerts a certain degree of stress on oxygen-dependent metabolic processes throughout the body.	Oxygen	97-103	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	50-53
34508780-0	2021	Crystal Structure of Human Cysteamine Dioxygenase Provides a Structural Rationale for its Function as an Oxygen Sensor.	Oxygen	105-111	2-aminoethanethiol dioxygenase	Homo sapiens	27-49
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Oxygen	94-100	2-aminoethanethiol dioxygenase	Homo sapiens	0-22
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Oxygen	94-100	2-aminoethanethiol dioxygenase	Homo sapiens	24-27
34689421-0	2022	Intracellular imaging of metmyoglobin and oxygen using new dual purpose probe EYFP-Myoglobin-mCherry.	Oxygen	42-48	myoglobin	Homo sapiens	83-92
34689421-4	2022	We previously employed Forster resonance energy transfer (FRET) to read out the deoxygenation/oxygenation of myoglobin, creating the subcellular (O2 ) sensor Myoglobin-mCherry.	Oxygen	146-148	myoglobin	Homo sapiens	109-118
34689421-4	2022	We previously employed Forster resonance energy transfer (FRET) to read out the deoxygenation/oxygenation of myoglobin, creating the subcellular (O2 ) sensor Myoglobin-mCherry.	Oxygen	146-148	myoglobin	Homo sapiens	158-167
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Oxygen	249-251	2-aminoethanethiol dioxygenase	Homo sapiens	0-22
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Oxygen	249-251	2-aminoethanethiol dioxygenase	Homo sapiens	24-27
24257362-14	2013	CONCLUSIONS: ANXA2 is overexpressed in oxygen-induced retinal neovascularization in a mouse model.	Oxygen	39-45	annexin A2	Mus musculus	13-18
34508780-9	2021	Our findings also elucidate the structural basis for ADO functioning as an oxygen sensor by modifying N-degron substrates to transduce responses to hypoxia.	Oxygen	75-81	2-aminoethanethiol dioxygenase	Homo sapiens	53-56
34255249-7	2021	Also, kojic acid reduced the lipid peroxidation and reactive oxygen species in the Abeta + kojic acid co-treated mice brains.	Oxygen	61-67	amyloid beta (A4) precursor protein	Mus musculus	83-88
34857483-13	2022	Serum CyPA and MMP-9 levels were linearly negatively correlated with mean oxygen saturation during sleep (mean SaO2) (r = -0.595, p = 0.000; r = -0.570, p = 0.000).	Oxygen	74-80	peptidylprolyl isomerase A	Homo sapiens	6-10
23785149-11	2013	These results suggest that oxygen tension regulates the necdin protein level in NSCs through HIF-2alpha-mediated proteasomal degradation to modulate their proliferation and apoptosis.	Oxygen	27-33	endothelial PAS domain protein 1	Mus musculus	93-103
34405936-3	2021	In the present study, a simple gas-solid treatment with ferrous oxalate has been proposed to uniformly coat a thin spinel phase layer with oxygen vacancy and simultaneously realize Fe-ion substitution in the surface.	Oxygen	139-145	gastrin	Homo sapiens	31-34
34696153-0	2021	Resolving Cross-Sensitivity Effect in Fluorescence Quenching for Simultaneously Sensing Oxygen and Ammonia Concentrations by an Optical Dual Gas Sensor.	Oxygen	88-94	gastrin	Homo sapiens	141-144
34927950-1	2021	The degradation mechanism in a sodium cell of a layered Na0.48 Al0.03 Co0.18 Ni0.18 Mn0.47 O2 (NCAM) cathode with P3/P2 structure is investigated by revealing the changes in microstructure and composition upon cycling.	Oxygen	91-93	neural cell adhesion molecule 1	Homo sapiens	95-99
34627424-0	2021	(beta-arrestin1 Promotes the Concentration of Mitochondrial Reactive Oxygen in T-ALL Cells via MiR-652-5p).	Oxygen	69-75	microRNA 652	Homo sapiens	95-102
23628781-2	2013	Using SLN knockout (Sln(-/-)) mice we show that SLN ablation increases the transport stoichiometry of SERCA pumps (Ca(2+) uptake/Ca(2+)-ATPase activity) and decreases the relative contribution of SERCA pumps to resting oxygen consumption (VO2) in soleus without affecting soleus or whole body VO2.	Oxygen	219-225	sarcolipin	Mus musculus	48-51
34587716-0	2021	Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis.	Oxygen	56-62	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	184-187
34374478-3	2021	Herein, we developed a SrMn 3 O 6-x -SrMnO 3 (SMO x -SMO) heterostructure through epitaxial growth, which demonstrated excellent electrocatalyst performance for oxygen reduction reaction (ORR).	Oxygen	161-167	smoothened, frizzled class receptor	Homo sapiens	46-49
34374478-3	2021	Herein, we developed a SrMn 3 O 6-x -SrMnO 3 (SMO x -SMO) heterostructure through epitaxial growth, which demonstrated excellent electrocatalyst performance for oxygen reduction reaction (ORR).	Oxygen	161-167	smoothened, frizzled class receptor	Homo sapiens	53-56
34610057-6	2021	The nanocomposites demonstrated photoluminescence (PL) quenching owing to the transfer of electrons from MEH-PPV to the defective energy levels (oxygen vacancies) of MgO.	Oxygen	145-151	epoxide hydrolase 1	Homo sapiens	105-108
34610057-10	2021	Hence, this work validates the role of oxygen vacancies of MgO nanoparticles in the PL quenching and photostability enhancement of MEH-PPV.	Oxygen	39-45	epoxide hydrolase 1	Homo sapiens	131-134
34691141-4	2021	HBB may promote the combination of hemoglobin and oxygen as well as angiogenesis for high-altitude adaptation in Tibetan pigs.	Oxygen	50-56	hemoglobin subunit beta	Sus scrofa	0-3
34553919-1	2021	Herein, a versatile ECL biosensor was fabricated for ultrasensitive detection of microRNA-21 (miRNA-21) from cancer cells based on a novel H2O2-free electrochemiluminescence (ECL) system (luminol/dissolved oxygen/Fe@Fe2O3 nanowires).	Oxygen	206-212	microRNA 21	Homo sapiens	81-92
34553919-1	2021	Herein, a versatile ECL biosensor was fabricated for ultrasensitive detection of microRNA-21 (miRNA-21) from cancer cells based on a novel H2O2-free electrochemiluminescence (ECL) system (luminol/dissolved oxygen/Fe@Fe2O3 nanowires).	Oxygen	206-212	microRNA 21	Homo sapiens	94-102
23656741-0	2013	A first-principles study on defect association and oxygen ion migration of Sm3+ and Gd3+ co-doped ceria.	Oxygen	51-57	GRDX	Homo sapiens	84-87
34378281-0	2021	Stabilizing transition metal vacancy induced oxygen redox by Co2+/Co3+ redox and sodium-site doping for layered cathode materials.	Oxygen	45-51	complement C2	Homo sapiens	61-64
23732018-8	2013	Limbal epithelial cells expanded in 2% O2 exhibited slow growth, low fraction of cells in S/G2 , high CFE, high expression of stem cell markers ABCG2 and p63alpha, and low fraction of differentiation marker CK3 resembling a LESC phenotype.	Oxygen	39-41	tumor protein p63	Homo sapiens	154-162
34621741-6	2021	Our results demonstrate severe hypoxic stress (0.1% oxygen) caused ATM auto-phosphorylation and activation (pS1981), H3K9me3, and elevated both Suv39H1 and Tip60 protein levels in FTC133 and HCT116 cell lines.	Oxygen	52-58	ATM serine/threonine kinase	Homo sapiens	67-70
34671319-1	2021	Myoglobin (MB) is an oxygen-binding protein usually found in cardiac myocytes and skeletal muscle fibers.	Oxygen	21-27	myoglobin	Homo sapiens	0-9
34671319-1	2021	Myoglobin (MB) is an oxygen-binding protein usually found in cardiac myocytes and skeletal muscle fibers.	Oxygen	21-27	myoglobin	Homo sapiens	11-13
34296320-14	2021	ZBED6 also reduced mitochondrial JC-1 J-aggregate formation, mitochondrial oxygen consumption rates (OCR) and mitochondrial reactive oxygen species (ROS) production, both at basal and palmitate + high glucose-stimulated conditions.	Oxygen	75-81	zinc finger BED-type containing 6	Homo sapiens	0-5
34544605-1	2022	Antonini and Brunori"s 1971 book "Hemoglobin and Myoglobin in Their Reactions with Ligands" was a truly remarkable publication that summarized almost 100 years of research on O2 binding to these globins.	Oxygen	175-177	myoglobin	Homo sapiens	49-58
23852002-4	2013	Microarray analysis showed three differentially expressed miRNAs in passage 7 (P7) Ercc1-/- MEFs grown at 20% O2 compared to Ercc1-/- MEFs grown at 3% O2.	Oxygen	110-112	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	83-88
34544605-2	2022	Over the ensuing 50 years, ultra-fast laser photolysis techniques, high-resolution and time resolved X-ray crystallography, molecular dynamics simulations, and libraries of recombinant myoglobin (Mb) and hemoglobin (Hb) variants have provided structural interpretations of O2 binding to these proteins.	Oxygen	273-275	myoglobin	Homo sapiens	185-194
34519748-2	2021	This study proposes an effective strategy for the construction of Fe doped CoP nanosheet arrays wrapped by graphene (F0.25CP-G) on nickel foam as an efficient electrocatalyst for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER).	Oxygen	225-231	caspase recruitment domain family member 16	Homo sapiens	75-78
34482039-12	2021	CONCLUSIONS: Reversible alteration of mRNA levels by removing morphine from culture medium, and effect of NAC in co-treatment of morphine plus NAC, emphasize the role of reactive oxygen species in down-regulation of the expression of hTERT and TERF2 by morphine.	Oxygen	179-185	telomerase reverse transcriptase	Homo sapiens	234-239
23852002-5	2013	Thirty-six differentially expressed miRNAs were identified in Ercc1-/- MEFs at P7 compared to early passage (P3) in 3% O2.	Oxygen	119-121	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	62-67
34564011-9	2021	A significant increase of energy expenditure and oxygen cost was found in individuals with CP compared to TD age-matched individuals, with a strong relationship across GMFCS levels.	Oxygen	49-55	ceruloplasmin	Homo sapiens	91-93
23590659-1	2013	Adult hemoglobin is a heterotetramer composed of two alpha-globin chains and two beta-globin chains (alpha2 beta2 ), each of which contains a heme molecule capable of binding oxygen and facilitating oxygen transport.	Oxygen	175-181	hemoglobin subunit beta	Homo sapiens	81-92
34564011-11	2021	Analysis suggests oxygen cost being the preferred/unbiased physiological parameter to assess walking efficacy in CP.	Oxygen	18-24	ceruloplasmin	Homo sapiens	113-115
34526801-7	2021	Additionally, LCC-09 attenuated TNFalpha-induced generation of reactive oxygen species in ECs.	Oxygen	72-78	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	32-40
23590659-1	2013	Adult hemoglobin is a heterotetramer composed of two alpha-globin chains and two beta-globin chains (alpha2 beta2 ), each of which contains a heme molecule capable of binding oxygen and facilitating oxygen transport.	Oxygen	199-205	hemoglobin subunit beta	Homo sapiens	81-92
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Oxygen	54-60	NLR family, pyrin domain containing 3	Mus musculus	86-148
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Oxygen	54-60	NLR family, pyrin domain containing 3	Mus musculus	150-155
34246872-2	2021	Here, we analyzed patterns of gene expression and oxygen consumption rates in B-cell subpopulations from humans and mice and described a model of HIF-1alpha-mediated B-cell metabolic reprogramming during the germinal center (GC) reaction.	Oxygen	50-56	hypoxia inducible factor 1, alpha subunit	Mus musculus	146-156
23539316-1	2013	In both obesity and chronic obstructive pulmonary disease (COPD), altered oxygen tension in adipose tissue (AT) has been suggested to evoke AT dysfunction, subsequently contributing to metabolic complications.	Oxygen	74-80	WD and tetratricopeptide repeats 1	Mus musculus	92-99
34375639-7	2021	METTL3 coordinated with YTHDF2 to suppress the expression of PGC-1alpha, as well as that of cytochrome c (CYCS) and NADH:ubiquinone oxidoreductase subunit C2 (NDUFC2), and reduced ATP production and oxygen consumption rate (OCR).	Oxygen	199-205	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	0-6
34375639-7	2021	METTL3 coordinated with YTHDF2 to suppress the expression of PGC-1alpha, as well as that of cytochrome c (CYCS) and NADH:ubiquinone oxidoreductase subunit C2 (NDUFC2), and reduced ATP production and oxygen consumption rate (OCR).	Oxygen	199-205	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	24-30
34118470-5	2021	The CAD/CAM device was also associated with a significant decrease in AHI (mean AHI after treatment 9.4+-6.7 events/h, p=0.003) and oxygen desaturation index (mean ODI of >= 3%/h 11.9+-6.8, p=0.011).	Oxygen	132-138	aconitate decarboxylase 1	Homo sapiens	4-11
34608438-0	2021	Dynamic Oxygen Conditions Promote the Translocation of HIF-1alpha to the Nucleus in Mouse Blastocysts.	Oxygen	8-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	55-65
34608438-3	2021	In this study, we evaluated the effect of dynamic oxygen conditions on the expression of embryonic genes and translocation of hypoxia-inducible factor-1alpha (HIF-1alpha) in cultured mouse blastocysts.	Oxygen	50-56	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-157
34608438-3	2021	In this study, we evaluated the effect of dynamic oxygen conditions on the expression of embryonic genes and translocation of hypoxia-inducible factor-1alpha (HIF-1alpha) in cultured mouse blastocysts.	Oxygen	50-56	hypoxia inducible factor 1, alpha subunit	Mus musculus	159-169
34608438-11	2021	Our study suggests that dynamic oxygen concentrations increase the developmental capacity in mouse preimplantation embryos through activation of the potent transcription factor HIF-1alpha.	Oxygen	32-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-187
34133989-0	2021	Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway.	Oxygen	64-70	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	158-162
23467670-5	2013	Genetic interaction analysis for one of these mutants, the RNase-encoding POP2 gene, revealed synthetic sick interactions with a number of genes involved in oxygen sensing and response.	Oxygen	157-163	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	74-78
34424683-11	2021	The bifunctional oxygen electrocatalytic activity and ZAB performance, on the other hand, are measured in terms of potential gap between the ORR and OER, DeltaE = Ej10OER - E1/2ORR, specific capacity, peak power density, open circuit voltage, voltaic efficiency, and charge-discharge cycling stability.	Oxygen	17-23	small nucleolar RNA, H/ACA box 73A	Homo sapiens	173-180
34385713-3	2021	Mechanistically, autoantibodies and interferon-alpha present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREMalpha to the glutathione peroxidase 4 (Gpx4, the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species.	Oxygen	340-346	glutathione peroxidase 4	Mus musculus	179-203
34385713-3	2021	Mechanistically, autoantibodies and interferon-alpha present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREMalpha to the glutathione peroxidase 4 (Gpx4, the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species.	Oxygen	340-346	glutathione peroxidase 4	Homo sapiens	205-209
23311338-8	2013	Growth factors stimulate HSC/HPC proliferation in a dose-dependent manner and this response is modulated by oxygen tension.	Oxygen	108-114	fucosyltransferase 1 (H blood group)	Homo sapiens	25-28
34502385-4	2021	Stimulation of cells with exogenous S1P under normoxic conditions (21% O2) led to a dose-dependent increase in Epo mRNA and protein levels and subsequent release of Epo into the medium.	Oxygen	71-73	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
34502385-4	2021	Stimulation of cells with exogenous S1P under normoxic conditions (21% O2) led to a dose-dependent increase in Epo mRNA and protein levels and subsequent release of Epo into the medium.	Oxygen	71-73	erythropoietin	Mus musculus	111-114
34502385-4	2021	Stimulation of cells with exogenous S1P under normoxic conditions (21% O2) led to a dose-dependent increase in Epo mRNA and protein levels and subsequent release of Epo into the medium.	Oxygen	71-73	erythropoietin	Mus musculus	165-168
34630054-10	2021	A central function of the ARNT2 protein is to act as one part of a sensor system indicating low levels of oxygen in brain tissue and to activate appropriate responses, including activation of glycolysis.	Oxygen	106-112	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	26-31
34423968-9	2021	The cobalt iron oxide samples obtained from ARP also possess superior oxygen evolution activity (307 mV overpotential at 10 mA cm-2 mug-1) compared to a mixture of Co3O4 and Fe2O3 (422 mV) or pure cobalt oxide (350 mV), highlighting the structure-induced enhancement of the catalytic activity.	Oxygen	70-76	cysteine rich secretory protein 1	Homo sapiens	44-47
34457111-4	2021	Irisin also improved glucose metabolism and significantly reduced LPS-induced levels of reactive oxygen species by increasing the activities of antioxidant enzymes, glutathione peroxidase (GPX), and superoxide dismutase (SOD), as well as levels of reduced glutathione (GSH).	Oxygen	97-103	fibronectin type III domain containing 5	Homo sapiens	0-6
34242037-1	2021	Experiments were performed at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron facility to investigate the electron-transfer reduction reaction of dipositive Lr (Z = 103) with O2 gas.	Oxygen	187-189	gastrin	Homo sapiens	190-193
34242037-3	2021	The produced 255Lr2+ ions were trapped and O2 gas was introduced, such that the charge-exchange reaction to reduce 255Lr2+ to 255Lr1+ was observed and the reaction rate constant was determined to be k = 1.5(7) x 10-10 cm3/mol/s.	Oxygen	43-45	gastrin	Homo sapiens	46-49
34447788-7	2021	We find that even in the presence of the oxygen-rich sites presented by the neighboring peripheral membrane-binding C2 domain, the thiol-rich sites can successfully compete for the available Cd2+.	Oxygen	41-47	CD2 molecule	Homo sapiens	191-194
34447788-8	2021	Our results indicate that Cd2+ can target the entire membrane-binding regulatory region of PKCs, and that the competition between the thiol- and oxygen-rich sites will likely determine the activation pattern of PKCs.	Oxygen	145-151	CD2 molecule	Homo sapiens	26-29
34353274-3	2022	Similar findings are obtained regarding protease inhibitors" effect on cytokine-induced neutrophil activation that suppresses Granulocyte-macrophage colony-stimulating-factor (GM-CSF) TNF-alpha-induced O2 release and adherence in human neutrophils without affecting phosphorylation of Extracellular signal-regulated kinase (ERK) and p38.	Oxygen	202-204	colony stimulating factor 2	Homo sapiens	126-174
34353274-3	2022	Similar findings are obtained regarding protease inhibitors" effect on cytokine-induced neutrophil activation that suppresses Granulocyte-macrophage colony-stimulating-factor (GM-CSF) TNF-alpha-induced O2 release and adherence in human neutrophils without affecting phosphorylation of Extracellular signal-regulated kinase (ERK) and p38.	Oxygen	202-204	colony stimulating factor 2	Homo sapiens	176-182
34393650-1	2021	Hypoxia-inducible factor- (HIF-) 1alpha has been implicated in the ability of cells to adapt to alterations in oxygen levels.	Oxygen	111-117	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-39
34112437-1	2021	We designed a signal-on photoelectrochemical (PEC) immunoassay for the sensitive monitoring of prostate-specific antigen (PSA) based on the etching reaction of hydrogen peroxide (H2O2) toward oxygen/phosphorus co-doped graphitic C3N4/AgBr/MnO2 nanosheets (OP-g-C3N4/AgBr/MnO2).	Oxygen	192-198	kallikrein related peptidase 3	Homo sapiens	95-120
34302034-3	2021	Galactose replacement alone blocked enhanced usage of the glycolysis pathway by IL1beta-activated chondrocytes as detected by real-time changes in the rates of proton acidification of the medium and changes in oxygen consumption.	Oxygen	210-216	interleukin 1 alpha	Homo sapiens	80-87
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Oxygen	81-87	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	331-336
34232022-5	2021	Gaseous  OH and H2O2 generated from the oxidation of H2O and reduction of O2 by TiO2 were directly detected in the photocatalysis process, and they were identified as the determining factor for SAg-H2SO4 formation.	Oxygen	74-76	S-antigen visual arrestin	Homo sapiens	194-197
34285132-4	2021	Here, we used immunoprecipitation-based mass spectrometry to characterize the PTMs and binding partners for full-length HIF-1alpha and HIF-2alpha under normoxic (21% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	166-172	endothelial PAS domain protein 1	Homo sapiens	135-145
34285132-4	2021	Here, we used immunoprecipitation-based mass spectrometry to characterize the PTMs and binding partners for full-length HIF-1alpha and HIF-2alpha under normoxic (21% oxygen) and hypoxic (1% oxygen) conditions.	Oxygen	190-196	endothelial PAS domain protein 1	Homo sapiens	135-145
34356178-1	2021	Defining the relationship between vascular development and the expression of hypoxia-inducible factors (Hifs) and vascular endothelial growth factor (Vegf) in the auditory brainstem is important to understand how tissue hypoxia caused by oxygen shortage contributes to sensory deficits in neonates.	Oxygen	238-244	vascular endothelial growth factor A	Rattus norvegicus	114-148
34356178-1	2021	Defining the relationship between vascular development and the expression of hypoxia-inducible factors (Hifs) and vascular endothelial growth factor (Vegf) in the auditory brainstem is important to understand how tissue hypoxia caused by oxygen shortage contributes to sensory deficits in neonates.	Oxygen	238-244	vascular endothelial growth factor A	Rattus norvegicus	150-154
34269823-1	2022	PURPOSE: It is thought that orthodontic forces initially reduce periodontal blood flow during orthodontic tooth movement (OTM) via tissue compression with cells responding to concomitant oxygen deprivation with expression of vascular endothelial growth factor (VEGF) triggering angiogenesis via binding to its receptor VEGFR-2.	Oxygen	187-193	vascular endothelial growth factor A	Rattus norvegicus	225-259
34269823-1	2022	PURPOSE: It is thought that orthodontic forces initially reduce periodontal blood flow during orthodontic tooth movement (OTM) via tissue compression with cells responding to concomitant oxygen deprivation with expression of vascular endothelial growth factor (VEGF) triggering angiogenesis via binding to its receptor VEGFR-2.	Oxygen	187-193	vascular endothelial growth factor A	Rattus norvegicus	261-265
34269823-1	2022	PURPOSE: It is thought that orthodontic forces initially reduce periodontal blood flow during orthodontic tooth movement (OTM) via tissue compression with cells responding to concomitant oxygen deprivation with expression of vascular endothelial growth factor (VEGF) triggering angiogenesis via binding to its receptor VEGFR-2.	Oxygen	187-193	kinase insert domain receptor	Rattus norvegicus	319-326
34139017-8	2021	Transcription analysis of selected H. pylori genes by RT-qPCR indicated that HP1021 is directly involved in the oxygen-dependent control of H. pylori fecA3 and gluP genes, which are implicated in response to oxidative stress.	Oxygen	112-118	parkin coregulated	Homo sapiens	160-164
34145754-4	2021	Thus, in 655 nm laser-triggered PDT process, An-NP generates abundant 1 O2 with extra 1 O2 being trapped via the conversion into EPO-NP; while in the subsequent 785 nm laser-driven PTT process, the converted EPO-NP undergoes thermolysis to liberate the captured 1 O2 and regenerates An-NP.	Oxygen	88-90	erythropoietin	Mus musculus	129-132
34145754-4	2021	Thus, in 655 nm laser-triggered PDT process, An-NP generates abundant 1 O2 with extra 1 O2 being trapped via the conversion into EPO-NP; while in the subsequent 785 nm laser-driven PTT process, the converted EPO-NP undergoes thermolysis to liberate the captured 1 O2 and regenerates An-NP.	Oxygen	264-266	erythropoietin	Mus musculus	208-211
34234608-11	2021	Conclusion: These findings suggest that 3D-MS formed by MSCs, ECs and HSCs exposed to low concentrations of oxygen (1-3% O2) modulate human HSC behavior and mimics some features of the perivascular niche, which could reduce the use of animal models and deepen the relationship between the microenvironment of HSC and human hematological diseases development.	Oxygen	108-114	fucosyltransferase 1 (H blood group)	Homo sapiens	140-143
34234608-11	2021	Conclusion: These findings suggest that 3D-MS formed by MSCs, ECs and HSCs exposed to low concentrations of oxygen (1-3% O2) modulate human HSC behavior and mimics some features of the perivascular niche, which could reduce the use of animal models and deepen the relationship between the microenvironment of HSC and human hematological diseases development.	Oxygen	108-114	fucosyltransferase 1 (H blood group)	Homo sapiens	309-312
34109780-5	2021	The combined EXAFS and MD results showed that the Co2+ and Ni2+ ions are surrounded by a first solvation shell formed by six (Tf2N)- anions, each coordinating in a monodentate fashion by means of the oxygen atoms.	Oxygen	200-206	complement C2	Homo sapiens	50-53
34220513-16	2021	Compared to the oxygen-glucose deprivation/reperfusion group, the protein and mRNA expressions of p-JNK, Bax, cleaved Caspase3 was decreased significantly.	Oxygen	16-22	mitogen-activated protein kinase 8	Rattus norvegicus	100-103
34220513-16	2021	Compared to the oxygen-glucose deprivation/reperfusion group, the protein and mRNA expressions of p-JNK, Bax, cleaved Caspase3 was decreased significantly.	Oxygen	16-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	105-108
34235304-4	2021	To compensate for this declination, in this study, a simultaneous generation of power and syngas (CO and H2) was proposed in an integrated NG-oxygen-fired gas turbine unit (GTU).	Oxygen	142-148	gastrin	Homo sapiens	155-158
34235304-5	2021	Hence, the combustion chamber in the NG-oxygen-fired gas turbine cycle was replaced by an NG partial oxidation reactor, which converts it into syngas.	Oxygen	40-46	gastrin	Homo sapiens	53-56
34111237-8	2022	Furthermore, among inpatients, G-CSF administration was associated with increased need for high levels of oxygen supplementation and death (HR: 3.56, 95% CI: 1.19-10.2, P value: 0.024).	Oxygen	106-112	colony stimulating factor 3	Homo sapiens	31-36
34164397-0	2021	Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2alpha/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells.	Oxygen	199-205	Indian hedgehog signaling molecule	Homo sapiens	115-130
34184431-1	2021	BACKGROUND: The mechanisms whereby inhibitors of sodium-glucose linked cotransporter-2 (SGLT2) exert their nephroprotective effects in patients with diabetes are incompletely understood but have been hypothesized to include improved tissue oxygen tension within the renal cortex.	Oxygen	240-246	solute carrier family 5 member 2	Homo sapiens	49-86
34184431-1	2021	BACKGROUND: The mechanisms whereby inhibitors of sodium-glucose linked cotransporter-2 (SGLT2) exert their nephroprotective effects in patients with diabetes are incompletely understood but have been hypothesized to include improved tissue oxygen tension within the renal cortex.	Oxygen	240-246	solute carrier family 5 member 2	Homo sapiens	88-93
34184431-3	2021	We hypothesize that SGLT2 inhibitors have differential effects on renal tissue oxygen delivery and consumption in specific regions of the diabetic kidney, including the superficial cortex, containing SGLT2-rich components of proximal tubules, versus the deeper cortex and outer medulla, containing predominantly SGLT1 receptors.	Oxygen	79-85	solute carrier family 5 member 2	Homo sapiens	20-25
34184431-11	2021	This reduction in deeper Pk O2 had biological impact as demonstrated by increased renal EPO mRNA levels and circulating reticulocyte count.	Oxygen	28-30	erythropoietin	Rattus norvegicus	88-91
34418159-3	2021	Built upon our recent demonstration that the protection against oxygen-induced retinopathy by adenosine A2A receptor (A2A R) antagonists is most effective when administered at the hyperoxia (not hypoxic) phase, we here uncovered the cellular mechanism underlying the A2A R-mediated protection against early hyperoxia-induced retinal vascular loss by reversing the inhibition of cellular proliferation via possibly multiple signaling pathways.	Oxygen	64-70	adenosine A2a receptor	Homo sapiens	94-116
34418159-3	2021	Built upon our recent demonstration that the protection against oxygen-induced retinopathy by adenosine A2A receptor (A2A R) antagonists is most effective when administered at the hyperoxia (not hypoxic) phase, we here uncovered the cellular mechanism underlying the A2A R-mediated protection against early hyperoxia-induced retinal vascular loss by reversing the inhibition of cellular proliferation via possibly multiple signaling pathways.	Oxygen	64-70	adenosine A2a receptor	Homo sapiens	118-123
34418159-3	2021	Built upon our recent demonstration that the protection against oxygen-induced retinopathy by adenosine A2A receptor (A2A R) antagonists is most effective when administered at the hyperoxia (not hypoxic) phase, we here uncovered the cellular mechanism underlying the A2A R-mediated protection against early hyperoxia-induced retinal vascular loss by reversing the inhibition of cellular proliferation via possibly multiple signaling pathways.	Oxygen	64-70	adenosine A2a receptor	Homo sapiens	267-272
34539349-0	2021	Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges.	Oxygen	15-21	artemin	Homo sapiens	111-114
34153475-7	2021	RESULTS: The production of IL-1alpha from Sq-1979-1 cells was synergistically enhanced in lower serum (0.5% or 1.0% FBS) at the transcriptional level, and under hypoxia (1.0% oxygen) at the release level compared to that in the control medium supplemented with 10% FBS under normoxia.	Oxygen	175-181	interleukin 1 alpha	Mus musculus	27-36
34502052-0	2021	Involvement of Reactive Oxygen Species in ABA-Induced Increase in Hydraulic Conductivity and Aquaporin Abundance.	Oxygen	24-30	HvPIP2;3	Hordeum vulgare	93-102
34073016-3	2021	Despite significant efforts, the known KMO inhibitors lack blood-brain barrier (BBB) permeability and upon the mimicking of the substrate binding mode, are subject to produce reactive oxygen species as a side reaction.	Oxygen	184-190	kynurenine 3-monooxygenase	Homo sapiens	39-42
34264866-1	2021	The alpha ketoglutarate-dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is a Hypoxia-Inducible Factor (HIF) target that uses molecular oxygen to hydroxylate peptidyl prolyl residues.	Oxygen	141-147	egl-9 family hypoxia-inducible factor 3	Mus musculus	47-69
23565745-5	2013	Surface bridging oxygen (Obr) is found to play a decisive role in water adsorption forming rooted hydroxyl groups with the water H atoms.	Oxygen	17-23	leptin receptor	Homo sapiens	25-28
34264866-1	2021	The alpha ketoglutarate-dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is a Hypoxia-Inducible Factor (HIF) target that uses molecular oxygen to hydroxylate peptidyl prolyl residues.	Oxygen	141-147	egl-9 family hypoxia-inducible factor 3	Mus musculus	71-75
34408466-10	2021	Serum Trx-1 level was positively correlated with inflammatory factors (interleukin-6, C-reactive protein, procalcitonin) and index of sepsis severity (DeltaSOFA score, partial pressure of oxygen/fraction of inspired oxygen), all of which were significantly higher in non-survivors than survivors.	Oxygen	188-194	thioredoxin	Homo sapiens	6-11
34408466-10	2021	Serum Trx-1 level was positively correlated with inflammatory factors (interleukin-6, C-reactive protein, procalcitonin) and index of sepsis severity (DeltaSOFA score, partial pressure of oxygen/fraction of inspired oxygen), all of which were significantly higher in non-survivors than survivors.	Oxygen	216-222	thioredoxin	Homo sapiens	6-11
34070770-0	2021	Hollow CoP/FeP4 Heterostructural Nanorods Interwoven by CNT as a Highly Efficient Electrocatalyst for Oxygen Evolution Reactions.	Oxygen	102-108	caspase recruitment domain family member 16	Homo sapiens	7-10
23658965-2	2010	By contrast, these probe compounds were far less potent in blocking degradation of the p97-independent substrate oxygen-dependent degradation domain (ODD)-luciferase (IC50 &gt; 28 muM), underscoring their specificity towards p97.	Oxygen	113-119	melanotransferrin	Homo sapiens	87-90
34067078-3	2021	Serum IL-6 did not differ by inspired oxygen, whereas IL-10 at 60% and 93% of inspired oxygen was greater than with 30%.	Oxygen	87-93	interleukin 10	Rattus norvegicus	54-59
34719568-5	2021	Indeed, beta-arrestin-bias AT1R agonist (BBA), TRV027 caused significant long-lasting positive inotropic effects in preweaning mice without increasing serum aldosterone concentrations or inducing tachycardia, arrhythmias, increased cardiac oxygen consumption, and reactive oxygen species generation.	Oxygen	240-246	angiotensin II, type I receptor-associated protein	Mus musculus	27-31
34719568-5	2021	Indeed, beta-arrestin-bias AT1R agonist (BBA), TRV027 caused significant long-lasting positive inotropic effects in preweaning mice without increasing serum aldosterone concentrations or inducing tachycardia, arrhythmias, increased cardiac oxygen consumption, and reactive oxygen species generation.	Oxygen	273-279	angiotensin II, type I receptor-associated protein	Mus musculus	27-31
34820578-7	2022	Then, the P53 proteins disrupt the membrane potential of mitochondria, activate autophagy, suppress the reactive oxygen species in cancer cells, and finally result in tumor suppression.	Oxygen	113-119	transformation related protein 53, pseudogene	Mus musculus	10-13
23658965-2	2010	By contrast, these probe compounds were far less potent in blocking degradation of the p97-independent substrate oxygen-dependent degradation domain (ODD)-luciferase (IC50 &gt; 28 muM), underscoring their specificity towards p97.	Oxygen	113-119	melanotransferrin	Homo sapiens	225-228
34421919-5	2021	We also found that p32/C1qbp-deficient DCs exhibited impaired production of IL-1beta, IL-23, and mitochondrial reactive oxygen species (mtROS) after IMQ stimulation.	Oxygen	120-126	complement component 1, q subcomponent binding protein	Mus musculus	19-22
34421919-5	2021	We also found that p32/C1qbp-deficient DCs exhibited impaired production of IL-1beta, IL-23, and mitochondrial reactive oxygen species (mtROS) after IMQ stimulation.	Oxygen	120-126	complement component 1, q subcomponent binding protein	Mus musculus	23-28
34362878-0	2021	E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression.	Oxygen	82-88	E2F transcription factor 1	Homo sapiens	0-4
34362878-9	2021	These two oxygen-sensitive epigenetic events work in concert to repel E2F1 from the ESRP1 promoter, thereby diminishing ESRP1 expression under hypoxia.	Oxygen	10-16	E2F transcription factor 1	Homo sapiens	70-74
34777989-2	2021	Case report: A 13-year-old pediatric patient with congenital sideroblastic anemia associated with YARS2 mutation presenting with COVID-19 infection and worsening pericardial effusion followed by a respiratory failure refractory to supplemental oxygen therapy leading to cardiac arrest.	Oxygen	244-250	tyrosyl-tRNA synthetase 2	Homo sapiens	98-103
23240858-5	2013	Twenty individuals with alcohol dependence (six females; 90% Caucasian; mean age = 29.4) who were prospectively genotyped on the OPRM1 gene underwent blood oxygen level-dependent functional magnetic resonance imaging while performing a Stop-Signal Task.	Oxygen	156-162	opioid receptor mu 1	Homo sapiens	129-134
35580710-5	2022	Exposure to elevated PM2.5 and B(a)P levels increased the odds of oxygen therapy and death.	Oxygen	66-72	prohibitin 2	Homo sapiens	31-36
34282001-4	2021	We showed that mice that lack Nedd4 globally or only in the myeloid compartment are highly susceptible to systemic C. albicans infection, which correlates with heightened organ fungal burden, defective inflammatory response, impaired leukocyte recruitment to the kidneys, and defective reactive oxygen species expression by granulocytes.	Oxygen	295-301	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	30-35
23475074-4	2013	In particular, we focus on the oxygen-sensing role of ubiquinol-cytochrome c reductase binding protein (UQCRB) of mitochondrial Complex III through identification of the protein target and the mode of action of a natural small molecule, terpestacin.	Oxygen	31-37	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	104-109
34171179-7	2021	Use of oxygen concentrations at 21% increased (at call: APC 6.26%; during transfer: APC 7.14%), while oxygen concentrations above 40% decreased (at call: APC -5.73%; at transfer APC -8.89%).	Oxygen	7-13	cell division cycle 16	Homo sapiens	56-61
35568065-1	2022	Hyperglycemia induced reactive oxygen species oxidize macromolecules including cellular proteins leading to their accumulation in Endoplasmic Reticulum (ER) lumen which in turn activates unfolded protein response (UPR) sensors including, PERK (Protein Kinase RNA-Like ER Kinase).	Oxygen	31-37	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	238-242
35568065-1	2022	Hyperglycemia induced reactive oxygen species oxidize macromolecules including cellular proteins leading to their accumulation in Endoplasmic Reticulum (ER) lumen which in turn activates unfolded protein response (UPR) sensors including, PERK (Protein Kinase RNA-Like ER Kinase).	Oxygen	31-37	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	244-277
22923367-6	2013	Glycated alpha-synuclein causes increased genome damage both via its direct interaction with DNA and by increased generation of reactive oxygen species as glycation byproduct.	Oxygen	137-143	synuclein alpha	Homo sapiens	9-24
35278444-9	2022	Knockdown of MAPK15 resulted in decreased reactive oxygen species level and cell apoptosis induced by DON, indicating the existence of miR-330-MAPK15 regulatory axis in regulating DON toxicity.	Oxygen	51-57	microRNA 330	Homo sapiens	135-142
34321467-6	2021	Density functional theory calculations reveal that Ru1/D-NiFe LDH optimizes the adsorption energies of intermediates for hydrogen evolution reaction and promotes the O-O coupling at a Ru-O active site for oxygen evolution reaction.	Oxygen	205-211	Scm like with four mbt domains 1	Homo sapiens	51-54
23220688-1	2013	Previous studies showed that CCN3 is deregulated in early-onset pre-eclampsia (PE), a pregnancy disease associated with impaired trophoblast invasion, which leads to reduced fetal oxygen and nutrition support.	Oxygen	180-186	cellular communication network factor 3	Homo sapiens	29-33
34310591-1	2021	In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock.	Oxygen	35-41	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	82-90
35395477-4	2022	Under ultrasonic excitation, PpIX catalyzes oxygen to produce singlet oxygen and release TH287 to inhibit MTH1 activity, thereby causing the accumulation of 8-oxo-dGTP, which enhances DNA damage and further induces cell apoptosis.	Oxygen	44-50	nudix hydrolase 1	Homo sapiens	106-110
23478515-1	2013	Myoglobin, a simple oxygen binding protein, was reconstituted with various types of synthetic hemes to manipulate the heme-globin interactions.	Oxygen	20-26	myoglobin	Homo sapiens	0-9
34156979-5	2021	Mechanistically, Esrrg-deficient Treg cells presented with dysregulated mitochondria with decreased oxygen consumption as well as ATP and NAD+ production.	Oxygen	100-106	estrogen-related receptor gamma	Mus musculus	17-22
35615986-5	2022	Furthermore, the burst release of oxygen by MB destruction improves tumor oxygenation from 22 to 50%, which not only raises the production of singlet oxygen but also significantly reduces the expression of hypoxia-inducible factor-1 alpha and related genes, thus preventing angiogenesis and epithelial-mesenchymal transition.	Oxygen	34-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	206-238
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Oxygen	92-94	dynamin 1 like	Homo sapiens	19-23
34367973-0	2021	Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial-Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1alpha/PFKP Axis.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	124-134
34367973-0	2021	Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial-Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1alpha/PFKP Axis.	Oxygen	11-17	phosphofructokinase, platelet	Mus musculus	135-139
34367973-1	2021	Background: Tumor cells initiate hypoxia-induced mechanisms to fuel cell proliferation, invasion, and metastasis, largely mediated by low O2-responsive Hypoxia-Inducible Factor 1 Alpha (HIF-1alpha).	Oxygen	138-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	152-184
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Oxygen	187-189	dynamin 1 like	Homo sapiens	19-23
34367973-1	2021	Background: Tumor cells initiate hypoxia-induced mechanisms to fuel cell proliferation, invasion, and metastasis, largely mediated by low O2-responsive Hypoxia-Inducible Factor 1 Alpha (HIF-1alpha).	Oxygen	138-140	hypoxia inducible factor 1, alpha subunit	Mus musculus	186-196
35551311-2	2022	Tf-DHA-ASO-MnO2 shows an effective targeted cancer therapy ability through the ferroptosis caused by the production of excessive lipid peroxides resulting from the combined effect of glutathione exhaustion, reactive oxygen species generation and down-regulation of glutathione peroxidase 4.	Oxygen	216-222	glutathione peroxidase 4	Homo sapiens	265-289
22924690-7	2013	Pc9-loaded micelles generated singlet molecular oxygen in high yields.	Oxygen	30-54	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-3
35248619-9	2022	The adsorption of Pb2+ and Cd2+ on HPBC was mainly achieved by diffusion, oxygen functional group complexation, and precipitation.	Oxygen	74-80	CD2 molecule	Homo sapiens	27-30
35395428-0	2022	Novel mutations in EPO-R and oxygen-dependent degradation (ODD) domain of EPAS1 genes-a causative reason for Congenital Erythrocytosis.	Oxygen	29-35	endothelial PAS domain protein 1	Homo sapiens	74-79
35395428-7	2022	Among them, 4 mutations p. (Gln572Arg), p. (Ser565Ile), p. (Ile545Thr), p. (Gln591Glu) in the ODD (Oxygen-dependent degradation) domain of HIF2alpha, all these variations contributed to the formation of non-functional HIF2alpha.	Oxygen	99-105	endothelial PAS domain protein 1	Homo sapiens	139-148
35395428-7	2022	Among them, 4 mutations p. (Gln572Arg), p. (Ser565Ile), p. (Ile545Thr), p. (Gln591Glu) in the ODD (Oxygen-dependent degradation) domain of HIF2alpha, all these variations contributed to the formation of non-functional HIF2alpha.	Oxygen	99-105	endothelial PAS domain protein 1	Homo sapiens	218-227
34285564-8	2021	The results of Pearson correlation analysis and multiple linear regression showed that miR-126 levels were positively correlated with peak oxygen consumption (peak VO2) and metabolic equivalents (METs), and inversely associated with score on the Minnesota Living with Heart Failure Questionnaire (MLHF) as well as plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.	Oxygen	139-145	microRNA 126	Homo sapiens	87-94
34356628-6	2021	While glucose tolerance was unchanged, female APP/PS1 mice displayed exaggerated oxygen consumption and CO2 production, which was mitigated by NOB.	Oxygen	81-87	presenilin 1	Mus musculus	50-53
34242227-0	2021	Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans.	Oxygen	13-19	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	42-47
34242227-8	2021	We present evidence that the crosstalk between HIF-1 and SKN-1 is mediated by EGL-9, the prolyl hydroxylase that targets HIF-1 for oxygen-dependent degradation.	Oxygen	131-137	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	57-62
34208925-1	2021	This study aims to evaluate the agreement in maximum oxygen consumption (V O2max) between a running protocol and a ski mountaineering (SKIMO) protocol.	Oxygen	53-59	SKI proto-oncogene	Homo sapiens	115-118
34782583-4	2022	The results showed that MEG3 overexpression effectively inhibited the production of retinal neovascularization in oxygen-induced retinopathy mice.	Oxygen	114-120	maternally expressed 3	Mus musculus	24-28
23232596-3	2013	The results show that, under irradiation at 254 nm and independently of the presence of oxygen, the predominant reaction pathway is a photo-Fries rearrangement (PFR), yielding the PA isomer 2"-amino-5"-hydroxyacetophenone (PAI).	Oxygen	88-94	serpin family E member 1	Homo sapiens	223-226
35624329-9	2022	In addition, miR-144-3p was significantly reduced in the oxygen and glucose deprivation/reperfusion cell model, and miR-144-3p could directly target PTEN to regulate its expression.	Oxygen	57-63	phosphatase and tensin homolog	Homo sapiens	149-153
34234608-11	2021	Conclusion: These findings suggest that 3D-MS formed by MSCs, ECs and HSCs exposed to low concentrations of oxygen (1-3% O2) modulate human HSC behavior and mimics some features of the perivascular niche, which could reduce the use of animal models and deepen the relationship between the microenvironment of HSC and human hematological diseases development.	Oxygen	121-123	fucosyltransferase 1 (H blood group)	Homo sapiens	140-143
34248676-9	2021	As hypoxia time increased, the expression of VEGF increased gradually, but VEGF expression in group B (10% O2) was the highest.	Oxygen	107-109	vascular endothelial growth factor A	Rattus norvegicus	75-79
35624495-10	2022	Furthermore, TNF-alpha and IL-1beta increased in CIRI-derived exosomes could increase RIP3 phosphorylation in normal or oxygen-glucose deprivation/reoxygenation (OGD/R) conditions (P < 0.05).	Oxygen	120-126	interleukin 1 alpha	Mus musculus	27-35
34248676-10	2021	Group C (7% O2) had higher levels of IL-6, IL-10, and TNF-alpha.	Oxygen	12-14	interleukin 10	Rattus norvegicus	43-48
23232596-7	2013	As its concentration increases, the PFR product (PAI) competes with PA for light absorption and undergoes, in the presence of oxygen, a photooxygenation process leading to the formation of a peroxyester.	Oxygen	126-132	serpin family E member 1	Homo sapiens	49-52
23098688-6	2013	As a result of their catalytic and non-catalytic functions, ALDH3A1 and ALDH1A1 proteins protect inner ocular tissues from ultraviolet radiation and reactive oxygen-induced damage.	Oxygen	158-164	aldehyde dehydrogenase 1 family member A1	Homo sapiens	72-79
34202240-3	2021	Here, we report that hyperoxia regulates the cell cycle and retinal endothelial cell proliferation in a previously unknown Myc-dependent manner, which contributes to oxygen-induced retinopathy.	Oxygen	166-172	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	123-126
35603587-5	2022	Moreover, this amino acid substitution occurs at the same position as Hb Headington (beta72(E16)Ser Arg, HBB: c.219T>A, p.Ser73Arg), which showed increased oxygen affinity.	Oxygen	156-162	hemoglobin subunit beta	Homo sapiens	105-108
23364980-8	2013	RESULTS: LDH-release and CB expression in FATIICs were enhanced significantly in an oxygen-concentration-dependent manner during hyperoxia, whereas caspase-3 was not activated.	Oxygen	84-90	cathepsin B	Rattus norvegicus	25-27
35628663-9	2022	PSCs cultured in physoxia revealed the significant downregulation of DNMT3B, DNMT3L, TET1, and TET3 vs. air oxygen, accompanied by significantly reduced 5mC and 5hmC levels.	Oxygen	108-114	DNA methyltransferase 3 beta	Homo sapiens	69-75
34140566-3	2021	Our primary objective was to investigate the associations of post-stroke fatigue severity with oxygen uptake ((Formula: see text)O2) at peak exercise and the time constant of (Formula: see text)O2 kinetics (tau(Formula: see text)O2) at exercise onset.	Oxygen	194-196	microtubule associated protein tau	Homo sapiens	207-210
34140566-3	2021	Our primary objective was to investigate the associations of post-stroke fatigue severity with oxygen uptake ((Formula: see text)O2) at peak exercise and the time constant of (Formula: see text)O2 kinetics (tau(Formula: see text)O2) at exercise onset.	Oxygen	229-231	microtubule associated protein tau	Homo sapiens	207-210
34140566-7	2021	The FSS score was not associated with (Formula: see text)O2 at peak exercise during a symptom-limited graded exercise test (rho = - 0.264; p = 0.224), whereas it was significantly associated with tau(Formula: see text)O2 during a submaximal constant-load exercise test (rho = 0.530; p = 0.009).	Oxygen	218-220	microtubule associated protein tau	Homo sapiens	196-199
23364980-10	2013	IL-10-release decreased in an oxygen-concentration-dependent fashion, and preincubation of the cells with rIL-10 significantly reduced cellular necrosis and expression of CB in FATIICs which were exposed to 65%- and 85%-hyperoxia.	Oxygen	30-36	interleukin 10	Rattus norvegicus	0-5
23364980-10	2013	IL-10-release decreased in an oxygen-concentration-dependent fashion, and preincubation of the cells with rIL-10 significantly reduced cellular necrosis and expression of CB in FATIICs which were exposed to 65%- and 85%-hyperoxia.	Oxygen	30-36	interleukin 10	Rattus norvegicus	106-112
34168725-5	2021	In this context, the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain, increase in reactive oxygen species, and production of mitochondrial alterations that occur in T2DM.	Oxygen	363-369	microtubule associated protein tau	Homo sapiens	45-48
34179658-11	2021	Under the condition of the 18% EGR rate, increasing oxygen addition to 4% can reduce HC emissions by more than 50% and the total particle mass of B15 and B30 is reduced by 60.6% and 47.7%, respectively.	Oxygen	52-58	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	146-149
35575947-1	2022	BACKGROUND: Perioperative cerebral oxygen saturation (ScO2) has been reported to associate with postoperative delirium (POD) which is a common postoperative complication, however, the results were inconclusive.	Oxygen	35-41	synthesis of cytochrome C oxidase 2	Homo sapiens	54-58
35574675-6	2022	Following this, both inhibitor (MDM2) and activator (p19-ARF) protein levels in response to low oxygen stress were studied.	Oxygen	96-102	interleukin 23 subunit alpha	Homo sapiens	53-56
35546486-6	2022	In addition, MFAP2 promotes cell proliferation, glucose uptake, lactate production; increases ATP levels, extracellular acidification ratio, and oxygen consumption ratio in ovarian cancer cells and increases the expression of glycolytic proteins.	Oxygen	145-151	microfibril associated protein 2	Homo sapiens	13-18
34218929-7	2022	On multivariable analysis, having CP did not increase the odds of postoperative morbidity (OR 0.99, 95% CI 0.7-1.3), but higher ASA class, congenital lung malformation, gastrointestinal disease, coagulopathy, preoperative inotropic support, oxygen use, nutritional support, and steroid use significantly increase the odds of morbidity, all of which were more common in patients with CP.	Oxygen	241-247	ceruloplasmin	Homo sapiens	383-385
23364980-11	2013	CONCLUSION: Our study suggests that CB is enhanced in an oxygen- concentration-dependent manner, and IL-10 has an inhibitory effect on CB expression in FATIICs during hyperoxia.	Oxygen	57-63	cathepsin B	Rattus norvegicus	36-38
23223039-3	2013	Here, we show that Sut1 is also expressed in the presence of oxygen, and we identify a novel function for Sut1.	Oxygen	61-67	Sut1p	Saccharomyces cerevisiae S288C	19-23
34075924-0	2021	Tailoring the Co4+/Co3+ active sites in a single perovskite as a bifunctional catalyst for the oxygen electrode reactions.	Oxygen	95-101	complement C4A (Rodgers blood group)	Homo sapiens	14-17
34075924-2	2021	Herein, we designed and developed a new class of layered cation ordered single perovskite oxides (Pr0.9Ca0.1Co0.8Fe0.2O3-delta) with an optimum ratio of the Co4+/Co3+ oxidation state and oxygen vacancy for oxygen electrode reactions.	Oxygen	206-212	complement C4A (Rodgers blood group)	Homo sapiens	157-160
35625845-10	2022	During surgery, hemoglobin concentration and oxygen delivery (DO2) decreased more significantly in patients with high ES-ALC, although they had similar values of stroke volume and cardiac output to those of other patients.	Oxygen	45-51	allantoicase	Homo sapiens	121-124
35536460-0	2022	Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner.	Oxygen	76-82	small nucleolar RNA host gene 7	Homo sapiens	40-45
22998365-5	2013	Immediate resuscitation of hypoxic neonates with glucose, alone and along with oxygen, significantly downregulated (p &lt; .001) BAX mRNA expression.	Oxygen	79-85	BCL2 associated X, apoptosis regulator	Rattus norvegicus	129-132
34567850-6	2021	The CO-PROX reaction mechanism has been assessed by means of isotopic oxygen pulse experiments.	Oxygen	70-76	pyruvate dehydrogenase complex component X	Homo sapiens	7-11
34567850-7	2021	Altogether, CuO/CeO2 shows a greater oxygen lability, which facilitates lattice oxygen enrolment in the CO-PROX mechanism.	Oxygen	37-43	pyruvate dehydrogenase complex component X	Homo sapiens	107-111
34567850-7	2021	Altogether, CuO/CeO2 shows a greater oxygen lability, which facilitates lattice oxygen enrolment in the CO-PROX mechanism.	Oxygen	80-86	pyruvate dehydrogenase complex component X	Homo sapiens	107-111
35565123-6	2022	With 70 days of incubation each, CH4 production decreased from 4.55 L g-1-chemical oxygen demand (COD) at 42  C with methanogen/total population (M TP-1) ratio of 0.041 to 1.52 L g-1 COD (M TP-1 ratio 0.027) and then to 0.94 L g-1 COD ( M TP-1 ratio 0.026) after the temperature was shifted to 45  C and 48  C, respectively.	Oxygen	83-89	solute carrier family 40 member 1	Homo sapiens	146-152
22998365-6	2013	The BAX expression in epinephrine resuscitated and 100% oxygen resuscitated groups were found to be upregulated in the brain regions.	Oxygen	56-62	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
34567850-8	2021	In the case of CuO/cryptomelane, in spite of its lower oxygen mobility, the intrinsic structural water co-assists as active oxygen species involved in CO-PROX.	Oxygen	55-61	pyruvate dehydrogenase complex component X	Homo sapiens	154-158
34567850-8	2021	In the case of CuO/cryptomelane, in spite of its lower oxygen mobility, the intrinsic structural water co-assists as active oxygen species involved in CO-PROX.	Oxygen	124-130	pyruvate dehydrogenase complex component X	Homo sapiens	154-158
23235157-2	2013	A novel metabolic analysis that measures the real-time oxidation state of NAD(H) and the hemes of the electron transport chain and oxygen consumption within intact, living cells found that structurally distinct MEK1/2 inhibitors had an immediate, dose-dependent effect on mitochondrial metabolism.	Oxygen	131-137	mitogen-activated protein kinase kinase 1	Homo sapiens	211-217
34602388-0	2021	Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels.	Oxygen	21-27	microRNA 126	Homo sapiens	124-131
34602388-0	2021	Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels.	Oxygen	21-27	microRNA 342	Homo sapiens	136-143
35522478-5	2022	Owing to the presence of highly exposed Fe-N-C sites and well-tuned pore structures, isolated Fe atoms on porous carbon nanofiber framework (Fe-SA/NCF) exhibits decent oxygen reduction activity and stability in alkaline conditions via a near four-electron path, demonstrating superior performance as air cathode for zinc-air batteries (ZABs) to commercial Pt/C catalyst.	Oxygen	168-174	neutrophil cytosolic factor 4	Homo sapiens	147-150
22987685-1	2013	Hemoglobin (Hb), an oxygen-binding protein composed of four subunits (alpha1, alpha2, beta1, and beta2), is a well-known example of allosteric proteins that are capable of cooperative ligand binding.	Oxygen	20-26	adrenoceptor alpha 1D	Homo sapiens	70-76
34602388-1	2021	This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels.	Oxygen	56-62	microRNA 126	Homo sapiens	167-174
34602388-1	2021	This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels.	Oxygen	56-62	microRNA 342	Homo sapiens	179-186
35510396-0	2022	Monitoring and control of the release of soluble O2 from H2 O2 inside porous enzyme carrier for O2 supply to an immobilized D-amino acid oxidase.	Oxygen	49-51	D-amino acid oxidase	Homo sapiens	124-144
34602388-3	2021	The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect.	Oxygen	30-36	microRNA 126	Homo sapiens	224-231
23299479-0	2013	Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.	Oxygen	87-93	tissue inhibitor of metalloproteinase 3	Mus musculus	26-31
34602388-3	2021	The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect.	Oxygen	30-36	microRNA 342	Homo sapiens	236-243
34725710-1	2021	Erythropoietin enhances oxygen delivery and reduces hypoxia-induced cell death, but its pro-thrombotic activity is problematic for use of erythropoietin in treating hypoxia.	Oxygen	24-30	erythropoietin	Mus musculus	0-14
35452886-4	2022	With a limited external aeration (0.5-2.0 molO2 molS-1), the oxygen consumption (O/Sre) to its supplement (O/Sin) ratios increased from 50-71% (conventional H2S) to 83-92% (low H2S), indicating that low H2S flux promotes a sufficient oxygen utilization.	Oxygen	61-67	embryonal Fyn-associated substrate	Homo sapiens	109-112
35510396-0	2022	Monitoring and control of the release of soluble O2 from H2 O2 inside porous enzyme carrier for O2 supply to an immobilized D-amino acid oxidase.	Oxygen	96-98	D-amino acid oxidase	Homo sapiens	124-144
35510396-5	2022	The internally released O2 is used to drive the reaction of D-amino acid oxidase (oxidation of D-methionine) that is co-immobilized with the catalase in the same carrier.	Oxygen	24-26	D-amino acid oxidase	Homo sapiens	60-80
35505123-1	2022	BACKGROUND: Cerebral oxygen saturation (ScO2) can be measured non-invasively by near-infrared spectroscopy (NIRS) and correlates with cerebral perfusion.	Oxygen	21-27	synthesis of cytochrome C oxidase 2	Homo sapiens	40-44
35452886-4	2022	With a limited external aeration (0.5-2.0 molO2 molS-1), the oxygen consumption (O/Sre) to its supplement (O/Sin) ratios increased from 50-71% (conventional H2S) to 83-92% (low H2S), indicating that low H2S flux promotes a sufficient oxygen utilization.	Oxygen	234-240	embryonal Fyn-associated substrate	Homo sapiens	109-112
35404578-2	2022	Besides the great contribution of the conventional  O2- reactive species, a synergic effect between a singlet oxygen (1O2) and mobile hydroxyl radicals ( OHf) was first illustrated for removing NOx indoor gas (1O2 + 2NO   2NO2, NO2 +  OHf   HNO3), inhibiting the production of the byproducts of NO2.	Oxygen	52-54	gastrin	Homo sapiens	205-208
23299479-0	2013	Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.	Oxygen	87-93	epidermal growth factor receptor	Mus musculus	39-43
23299479-2	2013	Previous studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membrane-anchored metalloproteinase that regulates epidermal growth factor receptor (EGFR) signaling, reduces pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	266-272	epidermal growth factor receptor	Mus musculus	147-179
23340651-5	2013	Our results demonstrate that 3% O(2) augmented proliferation of BMSC, as well as the formation of colonies in the colony-forming unit assay (CFU-A), the percentage of quiescent cells, and the expression of stemness markers Rex-1 and Oct-4, thereby suggesting an increase in the stemness of culture when exposed to hypoxia.	Oxygen	32-36	REX1, RNA exonuclease 1	Mus musculus	223-228
35114305-0	2022	Oxygen sensors mediated HIF-1alpha accumulation and translocation: A pivotal mechanism of fine particles-exacerbated myocardial hypoxia injury.	Oxygen	0-6	hypoxia inducible factor 1, alpha subunit	Mus musculus	24-34
35114305-7	2022	Overall, our study provides valuable insight into the regulatory role of oxygen sensor-mediated HIF-1alpha stabilization and translocation in PM-exacerbated myocardial hypoxia injury, we suggest this adds significantly to understanding the mechanisms of haze particle-caused burden of cardiovascular disease.	Oxygen	73-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
35467865-3	2022	We use the adjoint of the Community Multiscale Air Quality model to investigate odd oxygen (Ox   O3 + NO2) sensitivities in California"s San Joaquin Valley (SJV) to precursor emissions from local and upwind sources.	Oxygen	84-90	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	137-140
23505621-0	2013	Genetic variants of uncoupling proteins-2 and -3 in relation to maximal oxygen uptake in different sports.	Oxygen	72-78	heat shock protein family B (small) member 3	Homo sapiens	31-48
35367825-4	2022	Primary hepatocytes overexpressing SIRT3 displayed increased oxygen consumption and a reduction in triglyceride accumulation.	Oxygen	61-67	sirtuin 3	Mus musculus	35-40
35367825-5	2022	In mice with hepatic SIRT3 overexpression, increased fasting beta-hydroxybutyrate levels were observed, coupled with an increase in oxygen consumption in isolated mitochondria and increased substrate utilization in liver homogenates.	Oxygen	132-138	sirtuin 3	Mus musculus	21-26
35307349-7	2022	Finally, using oxygen-glucose deprivation (OGD) as an in vitro model for ischemia, we show that BDNF-TrkB signaling negatively impairs clustering of the main scaffolding protein at GABAergic postsynapse, gephyrin, whereby reducing GABAergic neurotransmission post-ischemia.	Oxygen	15-21	gephyrin	Homo sapiens	204-212
22879008-2	2013	The hormone erythropoietin (EPO) is essential for maintenance of tissue oxygen supply by stimulating red blood cell production and promoting their survival.	Oxygen	72-78	erythropoietin	Mus musculus	12-26
35365973-2	2022	HIF-1alpha, an oxygen-sensitive transcription factor, has been reported to activate genes involved in cell proliferation and extracellular matrix recombination.	Oxygen	15-21	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-10
35579890-11	2022	Furthermore, CPT in oxygen-glucose deprivation neurons down-regulated Top1 level, attenuated NLRP3 inflammasome activation, and suppressed pyroptosis and inflammatory response.	Oxygen	20-26	NLR family, pyrin domain containing 3	Mus musculus	93-98
35338668-4	2022	The O2 - -generating system in leukocytes is consisted of membrane cytochrome b 558 protein (a complex of p22-phox and gp91-phox proteins) and cytosolic p40-phox, p47-phox and p67-phox proteins.	Oxygen	4-6	cytochrome b-245 alpha chain	Homo sapiens	106-114
35338668-4	2022	The O2 - -generating system in leukocytes is consisted of membrane cytochrome b 558 protein (a complex of p22-phox and gp91-phox proteins) and cytosolic p40-phox, p47-phox and p67-phox proteins.	Oxygen	4-6	neutrophil cytosolic factor 4	Homo sapiens	153-161
22879008-2	2013	The hormone erythropoietin (EPO) is essential for maintenance of tissue oxygen supply by stimulating red blood cell production and promoting their survival.	Oxygen	72-78	erythropoietin	Mus musculus	28-31
35571795-13	2022	Clamping stabilized the movements of PEG10, and the leading oxygen of PEG10 was able to penetrate LIMP-2 and head toward to the position occupied by PEG2.	Oxygen	60-66	scavenger receptor class B member 2	Homo sapiens	98-104
32355379-0	2013	Spatial extent and historical context of North Sea oxygen depletion in August 2010.	Oxygen	51-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
35348789-0	2022	Correction to: Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal beta-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.	Oxygen	80-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
35294968-5	2022	OGD-induced generation of O2   - or H2O2 enhanced autophagy by inducing the expression of Activating Molecule in BECN1-Regulated Autophagy Protein 1 (Ambra1) and Beclin1 in both cell types.	Oxygen	26-28	autophagy and beclin 1 regulator 1	Homo sapiens	90-148
35294968-5	2022	OGD-induced generation of O2   - or H2O2 enhanced autophagy by inducing the expression of Activating Molecule in BECN1-Regulated Autophagy Protein 1 (Ambra1) and Beclin1 in both cell types.	Oxygen	26-28	autophagy and beclin 1 regulator 1	Homo sapiens	150-156
35628663-12	2022	In conclusion, PSCs display oxygen-sensitive methylation patterns that correlate with the transcriptional and translational regulation of the de novo methylase DNMT3B.	Oxygen	28-34	DNA methyltransferase 3 beta	Homo sapiens	160-166
35606473-2	2022	It has a potential use in the medical setting as a monitoring and diagnostic tool by detecting molecular oxygen within gas pockets and thus may be a useful adjunct in respiratory monitoring.	Oxygen	105-111	gastrin	Homo sapiens	119-122
35531284-6	2022	Of which, EP3, EP4, EP5, and EP6 showed strong scavenging activities on DPPH , hydroxyl radical (HO ), and superoxide anion radical (O- 2 ).	Oxygen	133-137	prostaglandin E receptor 4	Homo sapiens	15-18
35512588-0	2022	Boosting hydrogen and oxygen evolution of porous CoP nanosheet arrays through electronic modulating with oxygen-anion-incorporation.	Oxygen	22-28	caspase recruitment domain family member 16	Homo sapiens	49-52
32355379-2	2013	Typical near-bed dissolved oxygen saturations in the stratified regions of the North Sea were 75-80 % while the well-mixed regions of the southern North Sea reached 90 %.	Oxygen	27-33	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
35512588-0	2022	Boosting hydrogen and oxygen evolution of porous CoP nanosheet arrays through electronic modulating with oxygen-anion-incorporation.	Oxygen	105-111	caspase recruitment domain family member 16	Homo sapiens	49-52
35512588-2	2022	Herein, the synthesis of self-supported directional flake oxygen-incorporated cobalt phosphide arrays (O-CoP) with efficient bifunctional catalytic active sites was achieved by in situ oxidation followed by phosphorization of cobalt metal-organic framework nanosheet arrays (Co-MOF).	Oxygen	58-64	caspase recruitment domain family member 16	Homo sapiens	105-108
35631990-0	2022	Electrospun Smart Oxygen Indicating Tag for Modified Atmosphere Packaging Applications: Fabrication, Characterization and Storage Stability.	Oxygen	18-24	long intergenic non-protein coding RNA 1194	Homo sapiens	36-39
35631990-4	2022	Ultraviolet light-activated kappa-carrageenan-based smart oxygen indicating tag was developed using the electrospinning technique in this study and its stability during storage was determined.	Oxygen	58-64	long intergenic non-protein coding RNA 1194	Homo sapiens	76-79
32355379-5	2013	Historical data over the last century from the International Council for the Exploration of the Sea oceanographic database highlight an increase in seasonal oxygen depletion and a warming over the past 20 years.	Oxygen	157-163	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	96-99
35631990-5	2022	Kappa-carrageenan was used with redox dye, sacrificial electron donor, photocatalyst, and solvent for preparing oxygen indicating electrospun tag.	Oxygen	112-118	long intergenic non-protein coding RNA 1194	Homo sapiens	142-145
35631990-8	2022	Oxygen sensitivity at different oxygen concentrations revealed that the tag was sensitive enough to detect as low as 0.4% oxygen.	Oxygen	32-38	long intergenic non-protein coding RNA 1194	Homo sapiens	72-75
23712868-7	2013	Expression of the HIF-1alpha oxygen-dependent degradation domain mutant in cells resulted in elevated AGR2 levels and an increased ability to induce HUVEC migration and tube formation in vitro and enhanced growth and vascularity of tumor xenografts in vivo, which were prevented by AGR2 knockdown.	Oxygen	29-35	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	282-286
35631990-8	2022	Oxygen sensitivity at different oxygen concentrations revealed that the tag was sensitive enough to detect as low as 0.4% oxygen.	Oxygen	122-128	long intergenic non-protein coding RNA 1194	Homo sapiens	72-75
35440632-5	2022	Intracellular NAD(P)(H) redox ratios reflecting elevated oxygen demand potentiate native coronary Kv1 activity in a Kvbeta2-dependent manner.	Oxygen	57-63	potassium voltage-gated channel subfamily A regulatory beta subunit 2	Homo sapiens	116-123
23479759-0	2013	Heat-shock protein 70 is involved in hyperbaric oxygen preconditioning on decompression sickness in rats.	Oxygen	48-54	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-21
35167880-0	2022	Hyperbaric oxygen therapy mitigates left ventricular remodeling, upregulates MMP-2 and VEGF, and inhibits the induction of MMP-9, TGF-beta1, and TNF-alpha in streptozotocin-induced diabetic rat heart.	Oxygen	11-17	vascular endothelial growth factor A	Rattus norvegicus	87-91
35507832-5	2022	Thus, CoP/CNTHPs can catalyze the hydrogen and oxygen evolution reactions effectively with overpotentials of 147 and 238 mV at 10 mA cm-2.	Oxygen	47-53	caspase recruitment domain family member 16	Homo sapiens	6-9
35582772-3	2022	The prepared Co@NC-800 catalyst has a half-wave potential (E 1/2= 0.835V) close to Pt/C and good stability in excess of Pt/C for oxygen reduction reaction (ORR).	Oxygen	129-135	ret proto-oncogene	Homo sapiens	120-124
35457010-1	2022	Rotenone (ROT) inhibits mitochondrial complex I, leading to reactive oxygen species formation, which causes neurodegeneration and alpha-synuclein (alpha-syn) aggregation and, consequently, Parkinson"s disease.	Oxygen	69-75	synuclein alpha	Homo sapiens	130-145
23101451-1	2013	OBJECT: The Carotid Occlusion Surgery Study (COSS) was conducted to determine if superficial temporal artery-middle cerebral artery (STA-MCA) bypass, when added to the best medical therapy, would reduce subsequent ipsilateral stroke in patients with complete internal carotid artery (ICA) occlusion and an elevated oxygen extraction fraction (OEF) in the cerebral hemisphere distal to the occlusion.	Oxygen	315-321	GCY	Homo sapiens	133-136
35457010-1	2022	Rotenone (ROT) inhibits mitochondrial complex I, leading to reactive oxygen species formation, which causes neurodegeneration and alpha-synuclein (alpha-syn) aggregation and, consequently, Parkinson"s disease.	Oxygen	69-75	synuclein alpha	Homo sapiens	147-156
35573119-4	2022	The uncoordinated oxygen atom in this eta1-OSO photoisomer impinges on one of the arene rings in a neighboring tosylate counter ion of 1 just enough that incipient nano-optomechanical transduction is observed.	Oxygen	18-24	secreted phosphoprotein 1	Homo sapiens	38-42
35344334-5	2022	FeP@NPC obtained at 900  C (FeP@NPC-900) exhibits excellent bifunctional oxygen electrocatalytic performance with a very low potential gap (DeltaE = E1/2ORR - Ej10OER) of 670 mV.	Oxygen	73-79	small nucleolar RNA, H/ACA box 73A	Homo sapiens	149-156
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	151-153	gastrin	Homo sapiens	32-35
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	151-153	gastrin	Homo sapiens	116-119
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	225-231	gastrin	Homo sapiens	32-35
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	225-231	gastrin	Homo sapiens	116-119
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	246-248	gastrin	Homo sapiens	32-35
35629564-4	2022	After process optimization, the gas transport properties through the membranes were determined on the basis of pure gas permeation including CH4, CO2, O2, and N2 for two specific applications: biogas sweetening (CH4/CO2) and oxygen-enriched air (O2/N2).	Oxygen	246-248	gastrin	Homo sapiens	116-119
35628152-2	2022	In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a considerable amount of iron is required daily for hemoglobin synthesis and erythroid cell proliferation.	Oxygen	76-82	myoglobin	Homo sapiens	52-61
35513867-13	2022	Moreover, stimulation with either native or modified OL-HSPB8-EVs showed a significant reduction in ubiquitinated protein, reactive oxygen species and mitochondrial depolarization, with OL-HSPB8-EVs exhibiting a more protective effect.	Oxygen	132-138	heat shock protein family B (small) member 8	Rattus norvegicus	56-61
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	ret proto-oncogene	Homo sapiens	253-256
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	phosphatase and tensin homolog	Homo sapiens	300-304
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Oxygen	169-175	dynamin 1 like	Homo sapiens	379-383
23295771-5	2013	METHODS AND RESULTS: Using real-time measurement of oxygen consumption and extracellular acidification, we show that basal mitochondrial respiration is increased, while maximum respiration and spare respiratory capacity are decreased in PINK1-/- mouse embryonic fibroblasts (MEF), as is the membrane potential.	Oxygen	52-58	PTEN induced putative kinase 1	Mus musculus	237-242
35199359-2	2022	Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood.	Oxygen	126-132	endothelial PAS domain protein 1	Homo sapiens	94-104
35563567-5	2022	Although differentiation of TG2 knock-out preadipocytes is phenotypically similar to the wild-type cells, the mitochondria of the knock-out beige cells have multiple impairments including an altered electron transport system generating lower electrochemical potential difference, reduced oxygen consumption, lower UCP1 protein content, and a higher portion of fragmented mitochondria.	Oxygen	288-294	transglutaminase 2, C polypeptide	Mus musculus	28-31
35513390-4	2022	The oxygen evolution activities of Ir1/TO-CoOOH and Ir1/VO-CoOOH are improved relative to CoOOH through different mechanisms.	Oxygen	4-10	nischarin	Homo sapiens	35-38
35513390-4	2022	The oxygen evolution activities of Ir1/TO-CoOOH and Ir1/VO-CoOOH are improved relative to CoOOH through different mechanisms.	Oxygen	4-10	nischarin	Homo sapiens	52-55
35321878-6	2022	A shortened analog of PSMalpha2 (PSMalpha21-12), lacking the nine C-terminal residues, activated both FPR1 and FPR2 to produce reactive oxygen species, whereas beta-arrestin recruitment was only mediated through FPR1.	Oxygen	136-142	formyl peptide receptor 2	Homo sapiens	111-115
35513390-6	2022	For Ir1/VO-CoOOH, a hydrogen bonding is formed between the coordinated oxygen of single-atom Ir center and the oxygenated intermediates, which stabilizes the intermediates and lowers the energy barrier of the rate-determining step.	Oxygen	71-77	nischarin	Homo sapiens	4-7
23505347-1	2013	Since divergence ~50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ~10-20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen storage capacity and prolonging dive time.	Oxygen	213-219	myoglobin	Homo sapiens	140-149
35343099-3	2022	Benefitting from the surface-exposed Ir-SAs, Ir1 /Ni1.6 Mn1.4 O4 reveals boosted oxygen evolution reaction (OER) performance, achieving overpotentials of 330 and 350 mV at current densities of 100 and 200 mA cm-2 in alkaline seawater.	Oxygen	81-87	nischarin	Homo sapiens	45-48
35184097-12	2022	The addition of the inadequate delivery of oxygen (IDO2) index to the ERT increased the sensitivity by 19.0% (95% CI, -2.5 to 40.7%; p = 0.05), but the sensitivity remained low and the accuracy of the test dropped by 8.9% (95% CI, 4.7-13.1%; p < 0.01).	Oxygen	43-49	indoleamine 2,3-dioxygenase 2	Homo sapiens	51-55
23451260-1	2013	Lung development occurs under relative hypoxia and the most important oxygen-sensitive response pathway is driven by Hypoxia Inducible Factors (HIF).	Oxygen	70-76	aryl hydrocarbon receptor nuclear translocator	Mus musculus	144-147
35453350-5	2022	Carnosine (beta-alanyl-L-histidine, Car) protects cells from the damage due to the reactive species derived from oxygen (ROS), nitrogen (RNS) or carbonyl groups (RCS).	Oxygen	113-119	CXADR pseudogene 1	Homo sapiens	36-39
35625589-0	2022	Hyperbaric Oxygen Therapy Improves Parkinson"s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1alpha Pathway.	Oxygen	11-17	sirtuin 1	Mus musculus	101-107
35563138-0	2022	Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics.	Oxygen	52-58	myoglobin	Homo sapiens	0-9
35563138-0	2022	Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics.	Oxygen	113-119	myoglobin	Homo sapiens	0-9
23451260-2	2013	HIFs are heterodimeric transcription factors of an oxygen-sensitive subunit, HIFalpha, and a constitutively expressed subunit, HIF1beta.	Oxygen	51-57	hypoxia inducible factor 1, alpha subunit	Mus musculus	77-85
35563138-1	2022	Myoglobin (Mb)-mediated oxygen (O2) delivery and dissolved O2 in the cytosol are two major sources that support oxidative phosphorylation.	Oxygen	24-30	myoglobin	Homo sapiens	0-9
35563138-1	2022	Myoglobin (Mb)-mediated oxygen (O2) delivery and dissolved O2 in the cytosol are two major sources that support oxidative phosphorylation.	Oxygen	32-34	myoglobin	Homo sapiens	0-9
35114096-0	2022	Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway.	Oxygen	81-87	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	43-47
23372707-2	2013	The Baltic Sea is an ideal research object for historical reconstruction, since it has experienced many fresh- and brackish water periods and is depleted of dissolved oxygen, which increases the sediment"s preservation potential.	Oxygen	167-173	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
35007154-4	2022	In-frame deletion mutations of adh genes conferred oxygen-dependent sensitivity to slightly alkaline pH (pH 7.2-7.6), within the range of values observed in human saliva.	Oxygen	51-57	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	31-34
34982511-1	2022	AIM: Fibroblast-like renal erythropoietin (Epo) producing (REP) cells of the corticomedullary border region "sense" a decrease in blood oxygen content following anaemia or hypoxaemia.	Oxygen	136-142	erythropoietin	Mus musculus	27-41
34982511-1	2022	AIM: Fibroblast-like renal erythropoietin (Epo) producing (REP) cells of the corticomedullary border region "sense" a decrease in blood oxygen content following anaemia or hypoxaemia.	Oxygen	136-142	erythropoietin	Mus musculus	43-46
35199907-6	2022	The mPRDX3 overexpression prevented the declines in maximum mitochondrial oxygen consumption rate and calcium retention capacity in Sod1KO.	Oxygen	74-80	peroxiredoxin 3	Mus musculus	4-10
35394760-2	2022	In this work, FeOOH nanorod with intrinsic oxygen vacancy supported on carbon paper (FeOOH/CP) is proposed as a high-performance electrocatalyst for converting nitrate to ammonia at room temperature.	Oxygen	43-49	ceruloplasmin	Homo sapiens	91-93
35456042-4	2022	Deletion of the lonp-1 gene in worms disturbed mitochondrial function, provoked reactive oxygen species accumulation, and impaired normal processes, such as growth, behavior, and lifespan.	Oxygen	89-95	lon peptidase 1, mitochondrial	Homo sapiens	16-22
35393829-0	2022	(Investigation on Oxygen Gas-liquid Mass Transfer in Sewage Pipelines Under Enhanced Ventilation).	Oxygen	18-24	gastrin	Homo sapiens	25-28
35393829-5	2022	The experimental and computational fluid dynamics (CFD) simulation methods were established to explore the law of oxygen gas-liquid mass transfer under the different sewage flow rates or wind speeds.	Oxygen	114-120	gastrin	Homo sapiens	121-124
35393829-7	2022	The results showed that increasing the gas-liquid flow rates can accelerate the oxygen mass transfer, and the volumetric mass transfer coefficient increased by 3.5x10-4 min-1 for every increase of 0.1 m s-1.	Oxygen	80-86	gastrin	Homo sapiens	39-42
23372707-6	2013	Thus, the Litorina Sea laminae were characterized by past oxygen deficiency and salinity increase.	Oxygen	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
35269472-6	2022	Measurement of mitochondrial respiration revealed a decreased oxygen consumption rate in platelets from Atgl-/- but not from platAtgl-/- mice.	Oxygen	62-68	patatin-like phospholipase domain containing 2	Mus musculus	104-108
23144459-3	2012	Low steady-state levels of H(2)S appear to be controlled primarily by efficient oxygen-dependent catabolism via sulfide quinone oxidoreductase, persulfide dioxygenase (ETHE1), rhodanese, and sulfite oxidase.	Oxygen	80-86	crystallin zeta	Homo sapiens	120-142
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	128-130	superoxide dismutase 3, extracellular	Mus musculus	0-34
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	128-130	superoxide dismutase 3, extracellular	Mus musculus	36-40
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	140-142	superoxide dismutase 3, extracellular	Mus musculus	0-34
35142393-3	2022	Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O2  - to H2 O2 whose activity requires the Cu transporter ATP7A.	Oxygen	140-142	superoxide dismutase 3, extracellular	Mus musculus	36-40
35202675-9	2022	The level of phosphorylated-4E-BP1, which causes translation of HIF-1alpha, was higher at 1% O2 than at 5% O2.	Oxygen	93-95	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	28-34
35202675-9	2022	The level of phosphorylated-4E-BP1, which causes translation of HIF-1alpha, was higher at 1% O2 than at 5% O2.	Oxygen	107-109	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	28-34
35202675-10	2022	Our results suggest that the sensitivity of tumor cells to anticancer drugs is dependent oxygen concentrations under hypoxic conditions, and involves 4E-BP1-dependent stabilization of the HIF-1alpha protein.	Oxygen	89-95	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	150-156
23168219-3	2012	F-TFKO adipose tissue exhibit decreased mtDNA copy number, altered levels of proteins of the electron transport chain, and perturbed mitochondrial function with decreased complex I activity and greater oxygen consumption and uncoupling.	Oxygen	202-208	WD and tetratricopeptide repeats 1	Mus musculus	7-14
35377454-6	2022	Leptin also boosts the effects of IL-4 in macrophages, leading to increased oxygen consumption, expression of macrophage markers associated with a tissue repair phenotype, and wound healing.	Oxygen	76-82	leptin	Mus musculus	0-6
35377454-6	2022	Leptin also boosts the effects of IL-4 in macrophages, leading to increased oxygen consumption, expression of macrophage markers associated with a tissue repair phenotype, and wound healing.	Oxygen	76-82	interleukin 4	Mus musculus	34-38
35379776-7	2022	Finally, we found that TMAO markedly induced the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) and production of reactive oxygen species, which contributed to PRMT5 expression and subsequent VCAM-1 expression.	Oxygen	151-157	vascular cell adhesion molecule 1	Mus musculus	220-226
35232968-2	2022	Herein, we show that reaction sites consisting of single Pt atoms and neighboring oxygen vacancies (VO) can be prepared on CeO2 (Pt1/CeO2) with unique catalytic properties for the reversible dehydrogenation and rehydrogenation of large molecules such as cyclohexane and methylcyclohexane.	Oxygen	82-88	zinc finger protein 77	Homo sapiens	129-137
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	endothelial PAS domain protein 1	Homo sapiens	149-159
35137036-7	2022	Expression of S. cerevisiae GPD2, which encodes NAD+-dependent glycerol-3-phosphate dehydrogenase, and GPP1 supported increased glycerol production by oxygen-limited chemostat cultures of O. parapolymorpha.	Oxygen	151-157	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	28-32
34472490-1	2022	HOXA transcript at the distal tip (HOTTIP), a newly identified long noncoding RNA, has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal apoptosis.	Oxygen	147-153	Hoxa distal transcript antisense RNA	Mus musculus	35-41
23164179-3	2012	In term and preterm infants, oxygen therapy should be guided by pulse oximetry that follows the interquartile range of preductal saturations of healthy term babies after vaginal birth at sea level.	Oxygen	29-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	187-190
35357625-0	2022	Ultrasound-targeted microbubble destruction (UTMD)-mediated miR-150-5p attenuates oxygen and glucose deprivation-induced cardiomyocyte injury by inhibiting TTC5 expression.	Oxygen	82-88	tetratricopeptide repeat domain 5	Rattus norvegicus	156-160
35193955-2	2022	GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-alpha (HIF1alpha)/VEGFA (vascular endothelial growth factor A) signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1alpha inhibition.	Oxygen	59-65	glutathione peroxidase 2	Homo sapiens	0-4
35193955-2	2022	GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-alpha (HIF1alpha)/VEGFA (vascular endothelial growth factor A) signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1alpha inhibition.	Oxygen	59-65	glutathione peroxidase 2	Homo sapiens	232-236
35222644-10	2022	Examination of cell death importation showed that the UA formed the expression of the iNOS and thus the cell generation and mitochondrial reactive oxygen generation, which created a reaction to cellular DNA damage by raising the protein levels of phospho-histone ATR and ATM.	Oxygen	147-153	ATM serine/threonine kinase	Homo sapiens	271-274
35084405-0	2022	Electrochemically activated Co-Prussian blue analogue derived amorphous CoB nanostructures: an efficient electrocatalyst for the oxygen evolution reaction.	Oxygen	129-135	metabolism of cobalamin associated B	Homo sapiens	72-75
35401669-6	2022	Furthermore, the toxic RNA expression caused mitochondrial dysfunction, excessive reactive oxygen species production, and DNA damage and response, resulting in the senescence-associated increase of cell cycle inhibitors p21 and p16 and secreted mediators insulin-like growth factor binding protein 3 (IGFBP3) and plasminogen activator inhibitor-1 (PAI-1).	Oxygen	91-97	insulin like growth factor binding protein 3	Homo sapiens	255-299
35303888-6	2022	The SGLT2is effects are most apparent when cells or hearts are subjected to pathological conditions (reactive oxygen species, inflammation, acidosis, hypoxia, high saturated fatty acids, hypertension, hyperglycemia, and heart failure sympathetic stimulation) that are known to prime these plasmalemmal sodium-loaders.	Oxygen	110-116	solute carrier family 5 member 2	Homo sapiens	4-9
22726275-6	2012	RESULTS: The IgG3 deficiency patient had significantly longer duration of admission and period of oseltamivir, with a significantly decreased pulse oxygen saturation and increased maximum serum C-reactive protein, creatine kinase and urinary excretion of beta2-microglobulin/creatinine, compared with the controls (P &lt; 0.05).	Oxygen	148-154	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	13-17
35247316-0	2022	The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.	Oxygen	78-84	arginyltransferase 1	Homo sapiens	29-49
35247316-3	2022	Here, we present an alternative oxygen-sensing pathway regulated by ATE1, an enzyme ubiquitously conserved in eukaryotes that influences protein degradation by posttranslational arginylation.	Oxygen	32-38	arginyltransferase 1	Homo sapiens	68-72
35247316-4	2022	We report that ATE1 centrally controls the hypoxic response and glycolysis in mammalian cells by preferentially arginylating HIF1alpha that is hydroxylated by PHD in the presence of oxygen.	Oxygen	182-188	arginyltransferase 1	Homo sapiens	15-19
35247316-6	2022	Bioinformatic analysis of human tumor data reveals that the ATE1/UBR and pVHL pathways jointly regulate oxygen sensing in a transcription-independent manner with different tissue specificities.	Oxygen	104-110	arginyltransferase 1	Homo sapiens	60-64
35270019-7	2022	DRG2 deficiency in endothelial cells upregulated arginase 2 (Arg2) and generation of reactive oxygen species.	Oxygen	94-100	developmentally regulated GTP binding protein 2	Mus musculus	0-4
35084406-5	2022	All these properties make the CSHS a direct Z-scheme system with the hydrogen and oxygen evolution reactions occurring, respectively, at the CdS and SnS2 layers.	Oxygen	82-88	CDP-diacylglycerol synthase 1	Homo sapiens	141-144
35207122-3	2022	The permeability of He, H2, N2, O2, CH4 and CO2 gases through these MMMs are analyzed as a function of the fraction of free volume (FFV) of the membrane and the kinetic diameter of the gas, allowing for the evaluation of the free volume.	Oxygen	32-34	gastrin	Homo sapiens	185-188
22913412-10	2012	However, the greater increases of the SOD, POX, APX, GST, GR, and CAT activities for BRS 229 compared with BR 18 contributed to the lower O2(-), H2O2, and MDA concentrations and EL verified in the former.	Oxygen	138-140	catalase-1	Triticum aestivum	66-69
35038580-0	2022	Exosome derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironment through modulating reactive oxygen species equilibrium via GLS1 mediated glutamine metabolism alteration.	Oxygen	145-151	glutaminase	Homo sapiens	176-180
23065119-3	2012	In the present work we demonstrate that heterologously expressed AAO1 and AAO3, two prominent members of the AO family from Arabidopsis thaliana, do not only generate hydrogen peroxide but also superoxide anions by transferring aldehyde-derived electrons to molecular oxygen.	Oxygen	268-274	aldehyde oxidase 1	Arabidopsis thaliana	65-69
35156537-0	2022	Ribophorin II promotes the epithelial-mesenchymal transition and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol-3-Kinase/Protein Kinase B activation.	Oxygen	145-151	protein tyrosine kinase 2 beta	Homo sapiens	199-215
23051045-3	2012	Upon lifting, the C 1s signal shows a downshift in binding energy, due to the charge transfer to graphene from the oxygen-covered metal surface.	Oxygen	115-121	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	18-21
35184673-11	2022	Inhibition of TAK1 expression could block p38 MAPK/TGF-beta1 signaling pathway and reduce ROS production and oxidative stress, which may be one of the signal pathways of TAK1 to reduce apoptosis of HK-2 cells induced by high glucose.Abbreviations: DN, Diabetic nephropathy; TAK1, transforming growth factor beta-activated kinase-1; TGF-beta, transforming growth factor-beta; NG, normal glucose; HG, high glucose; p38 MAPK, p38 mitogen-activated protein kinase; ROS, reactive oxygen species.	Oxygen	475-481	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	14-18
35184673-11	2022	Inhibition of TAK1 expression could block p38 MAPK/TGF-beta1 signaling pathway and reduce ROS production and oxidative stress, which may be one of the signal pathways of TAK1 to reduce apoptosis of HK-2 cells induced by high glucose.Abbreviations: DN, Diabetic nephropathy; TAK1, transforming growth factor beta-activated kinase-1; TGF-beta, transforming growth factor-beta; NG, normal glucose; HG, high glucose; p38 MAPK, p38 mitogen-activated protein kinase; ROS, reactive oxygen species.	Oxygen	475-481	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	170-174
35268729-1	2022	We used a grand canonical Monte Carlo simulation to study the influence of impurities including water vapor, SO2, and O2 in the flue gas on the adsorption of CO2/N2 mixture in carbon nanotubes (CNTs) and carboxyl doped CNT arrays.	Oxygen	118-120	gastrin	Homo sapiens	133-136
23328287-9	2012	And there was a similar correlation between oxygen uptake at anaerobic threshold (Vo(2AT)) and LAP (r = -0.17, P = 0.031).	Oxygen	44-50	LAP	Homo sapiens	95-98
35064631-0	2022	Oxygen Vacancy and Core-Shell Heterojunction Engineering of Anemone-Like CoP@CoOOH Bifunctional Electrocatalyst for Efficient Overall Water Splitting.	Oxygen	0-6	caspase recruitment domain family member 16	Homo sapiens	73-76
35064631-2	2022	Herein, an in situ integration engineering strategy of oxygen-vacancy and core-shell heterojunction to fabricate an anemone-like CoP@CoOOH core-shell heterojunction with rich oxygen-vacancies supported on carbon paper (CoP@CoOOH/CP), is described.	Oxygen	55-61	caspase recruitment domain family member 16	Homo sapiens	129-132
23006780-5	2012	Oxygen-toxicity significantly induced upregulation of peroxiredoxins 1 and 2, peroxiredoxin sulfonic form, thioredoxin 1, and sulfiredoxin 1 in the brains of infant rats.	Oxygen	0-6	peroxiredoxin 1	Homo sapiens	54-76
35064631-2	2022	Herein, an in situ integration engineering strategy of oxygen-vacancy and core-shell heterojunction to fabricate an anemone-like CoP@CoOOH core-shell heterojunction with rich oxygen-vacancies supported on carbon paper (CoP@CoOOH/CP), is described.	Oxygen	55-61	caspase recruitment domain family member 16	Homo sapiens	219-222
35064631-2	2022	Herein, an in situ integration engineering strategy of oxygen-vacancy and core-shell heterojunction to fabricate an anemone-like CoP@CoOOH core-shell heterojunction with rich oxygen-vacancies supported on carbon paper (CoP@CoOOH/CP), is described.	Oxygen	175-181	caspase recruitment domain family member 16	Homo sapiens	129-132
35064631-2	2022	Herein, an in situ integration engineering strategy of oxygen-vacancy and core-shell heterojunction to fabricate an anemone-like CoP@CoOOH core-shell heterojunction with rich oxygen-vacancies supported on carbon paper (CoP@CoOOH/CP), is described.	Oxygen	175-181	caspase recruitment domain family member 16	Homo sapiens	219-222
35064631-3	2022	Benefiting from the synergy of CoP core and oxygen-vacancy-rich CoOOH shell, the as-obtained CoP@CoOOH/CP catalyst displays low overpotentials at 10 mA cm-2 for HER (89.6 mV/81.7 mV) and OER (318 mV/200 mV) in neutral and alkaline media, respectively.	Oxygen	44-50	caspase recruitment domain family member 16	Homo sapiens	93-96
35107457-1	2022	An aqueous room-temperature phosphorescent (RTP) probe for Gd3+ is reported based on Gd3+-induced intersystem promoting effect and the oxygen-shielding property of the Gd3+/AMP/fluorescein coordination polymer nanoparticles (CPNs).	Oxygen	135-141	GRDX	Homo sapiens	59-62
35107457-1	2022	An aqueous room-temperature phosphorescent (RTP) probe for Gd3+ is reported based on Gd3+-induced intersystem promoting effect and the oxygen-shielding property of the Gd3+/AMP/fluorescein coordination polymer nanoparticles (CPNs).	Oxygen	135-141	GRDX	Homo sapiens	168-171
35192456-0	2022	The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells.	Oxygen	4-10	egl-9 family hypoxia-inducible factor 1	Mus musculus	18-45
23082875-0	2012	Relationship between oxygen affinity and autoxidation of myoglobin.	Oxygen	21-27	myoglobin	Homo sapiens	57-66
35192456-1	2022	The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1alpha and HIF2alpha) in numerous cell types, including T lymphocytes.	Oxygen	4-10	egl-9 family hypoxia-inducible factor 1	Mus musculus	18-45
35192456-1	2022	The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1alpha and HIF2alpha) in numerous cell types, including T lymphocytes.	Oxygen	4-10	egl-9 family hypoxia-inducible factor 1	Mus musculus	47-51
35192456-1	2022	The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1alpha and HIF2alpha) in numerous cell types, including T lymphocytes.	Oxygen	4-10	hypoxia inducible factor 1, alpha subunit	Mus musculus	149-158
35192456-1	2022	The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1alpha and HIF2alpha) in numerous cell types, including T lymphocytes.	Oxygen	4-10	endothelial PAS domain protein 1	Mus musculus	163-172
22726235-11	2012	Annexin-V-binding was significantly blunted by 100% oxygen and was virtually abolished in the nominal absence of Ca2+.	Oxygen	52-58	annexin A5	Homo sapiens	0-9
34998934-6	2022	Consistent with enhanced defense against ferroptosis, neurons from 5xFAD/GPX4 mice showed an augmented capacity to reduce lipid reactive oxygen species.	Oxygen	137-143	glutathione peroxidase 4	Mus musculus	73-77
22886911-9	2012	Under metabolic stress such as oxygen and glucose deprivation, PRODH/POX can be induced to serve as a tumor survival factor through ATP production or ROS-induced autophagy.	Oxygen	31-37	proline dehydrogenase 1	Homo sapiens	63-68
35216248-8	2022	In vitro studies using C8-B4 cells showed changes in cellular morphology and increased reactive oxygen species formation in response to acrolein (a product of SMOX activity) treatment.	Oxygen	96-102	spermine oxidase	Mus musculus	159-163
22886911-9	2012	Under metabolic stress such as oxygen and glucose deprivation, PRODH/POX can be induced to serve as a tumor survival factor through ATP production or ROS-induced autophagy.	Oxygen	31-37	proline dehydrogenase 1	Homo sapiens	69-72
22703470-7	2012	IGF-1 protected cells from 6-OHDA-induced insult by inhibiting intracellular reactive oxygen species generation.	Oxygen	86-92	insulin-like growth factor 1	Rattus norvegicus	0-5
35165280-6	2022	Based on the GO enrichment of miR-652-5p target genes, we uncovered that impaired miR-652-5p decreased glycolysis, including reduced the lactate, pyruvate, ATP level and the total extracellular acidification rate (ECAR), elevated oxygen consumption rate (OCR) in T-ALL cell lines.	Oxygen	230-236	microRNA 652	Homo sapiens	30-37
35165280-6	2022	Based on the GO enrichment of miR-652-5p target genes, we uncovered that impaired miR-652-5p decreased glycolysis, including reduced the lactate, pyruvate, ATP level and the total extracellular acidification rate (ECAR), elevated oxygen consumption rate (OCR) in T-ALL cell lines.	Oxygen	230-236	microRNA 652	Homo sapiens	82-89
22714395-9	2012	A group of upregulated genes, including Hemoglobin B (HBB), were involved in oxygen metabolism, and in vitro functional analysis of HBB revealed that its expression in the MDA subpopulations was associated with a reduced production of hydrogen peroxide.	Oxygen	77-83	hemoglobin subunit beta	Homo sapiens	40-52
22714395-9	2012	A group of upregulated genes, including Hemoglobin B (HBB), were involved in oxygen metabolism, and in vitro functional analysis of HBB revealed that its expression in the MDA subpopulations was associated with a reduced production of hydrogen peroxide.	Oxygen	77-83	hemoglobin subunit beta	Homo sapiens	54-57
22714395-9	2012	A group of upregulated genes, including Hemoglobin B (HBB), were involved in oxygen metabolism, and in vitro functional analysis of HBB revealed that its expression in the MDA subpopulations was associated with a reduced production of hydrogen peroxide.	Oxygen	77-83	hemoglobin subunit beta	Homo sapiens	132-135
35214964-5	2022	Energy performance analysis results indicated that the energy performance of Al/MoO3/NCM thermite spinning is the best when the value of combustion oxygen equivalent ratio (Phi) is 0.90-1.00.	Oxygen	148-154	CWC22 spliceosome associated protein homolog	Homo sapiens	85-88
22704605-13	2012	Our data demonstrate that repetitive systemic EPO treatment reverses microvascular dysfunction during wound healing in hypercholesterolaemic mice by inducing new vessel formation and by providing the wound with more oxygen.	Oxygen	216-222	erythropoietin	Mus musculus	46-49
35114641-4	2022	Expression of CTRP3 and lysosomal-associated membrane protein 1 (LAMP1) was detected in H9C2 cells treated with oxygen-glucose deprivation/reoxygenation (OGD/R).	Oxygen	112-118	lysosomal-associated membrane protein 1	Rattus norvegicus	24-63
35114641-4	2022	Expression of CTRP3 and lysosomal-associated membrane protein 1 (LAMP1) was detected in H9C2 cells treated with oxygen-glucose deprivation/reoxygenation (OGD/R).	Oxygen	112-118	lysosomal-associated membrane protein 1	Rattus norvegicus	65-70
23387278-0	2012	[Participation of the active oxygen forms in the induction of ascorbate peroxidase and guaiacol peroxidase under heat hardening of wheat seedlings].	Oxygen	29-35	peroxidase-like	Triticum aestivum	72-82
34991782-6	2022	Peroxidase (POD), polyphenol oxidase (PPO), and superoxide dismutase (SOD) activities significantly increased by SNP and NaHS treatment, and indoleacetic acid oxidase (IAAO) activity and the O2- and H2O2 content significantly decreased by SNP and NaHS treatment.	Oxygen	191-193	iron superoxide dismutase	Solanum lycopersicum	70-73
35120381-1	2022	As blood flows from the portal triad to the central vein, cell-mediated depletion establishes gradients of soluble factors such as oxygen, nutrients, and hormones, which act through molecular pathways (e.g., Wnt/beta-catenin, hedgehog) to spatially regulate hepatocyte functions along the sinusoid.	Oxygen	131-137	catenin beta 1	Homo sapiens	212-224
23387278-0	2012	[Participation of the active oxygen forms in the induction of ascorbate peroxidase and guaiacol peroxidase under heat hardening of wheat seedlings].	Oxygen	29-35	peroxidase-like	Triticum aestivum	96-106
35094287-0	2022	ICT1 deficiency leads to reduced oxygen resistance due to the cell wall damage in S. cerevisiae.	Oxygen	33-39	lysophosphatidic acid acyltransferase ICT1	Saccharomyces cerevisiae S288C	0-4
23025382-0	2012	Redox switching of adenosine-5"-phosphosulfate kinase with photoactivatable atomic oxygen precursors.	Oxygen	83-89	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	19-53
22896587-10	2012	In agreement with these findings, adipose tissue from eNOS transgenic mice showed higher levels of PPAR-alpha and PPAR-gamma gene expression, elevated abundance of mitochondrial proteins, and a higher rate of oxygen consumption.	Oxygen	209-215	nitric oxide synthase 3, endothelial cell	Mus musculus	54-58
35204143-9	2022	Ldhb-/- mice displayed enhanced reactive oxygen species (ROS) and lipid peroxidation (LPO) production, and they revealed depleted stores of cellular ATP, GSH:GSSG enzyme ratio, and downregulated expression of Nrf2 and HO-1 proteins, when compared to WT littermates.	Oxygen	41-47	lactate dehydrogenase B	Mus musculus	0-4
23202931-0	2012	Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity.	Oxygen	96-102	erythropoietin	Rattus norvegicus	0-14
34994574-5	2022	The tuned electrolyte not only enables a stable solid electrolyte interphase (SEI) with conformal inorganic components (including LiF, LiNxOy, and Li2O) that promotes a uniform Li electro-plating/stripping process but also results in a low charge overpotential, a stable discharge terminal plateau, and reversible O2 generation of the Li-O2 battery conducted in an open O2 environment.	Oxygen	314-316	LIF interleukin 6 family cytokine	Homo sapiens	130-133
34994574-5	2022	The tuned electrolyte not only enables a stable solid electrolyte interphase (SEI) with conformal inorganic components (including LiF, LiNxOy, and Li2O) that promotes a uniform Li electro-plating/stripping process but also results in a low charge overpotential, a stable discharge terminal plateau, and reversible O2 generation of the Li-O2 battery conducted in an open O2 environment.	Oxygen	370-372	LIF interleukin 6 family cytokine	Homo sapiens	130-133
35048936-0	2022	The controlled synthesis of nitrogen and iron co-doped Ni3S2@NiP2 heterostructures for the oxygen evolution reaction and urea oxidation reaction.	Oxygen	91-97	BCL2 interacting protein 2	Homo sapiens	61-65
22930723-6	2012	METHODS: Mice overexpressing eNOS-GFP were subjected to oxygen-induced retinopathy (OIR) and changes in retinal vascularization quantified.	Oxygen	56-62	nitric oxide synthase 3, endothelial cell	Mus musculus	29-33
35048936-2	2022	Herein, nitrogen and iron co-doped Ni3S2 and NiP2 heterostructures with high efficiency oxygen evolution reaction (OER) and urea oxidation reaction (UOR) performances were firstly successfully prepared on nickel foam by hydrothermal and high-temperature calcination methods.	Oxygen	88-94	BCL2 interacting protein 2	Homo sapiens	45-49
35018919-0	2022	Porous N-doped carbon with confined Fe-doped CoP grown on CNTs for superefficient oxygen evolution electrocatalysis.	Oxygen	82-88	caspase recruitment domain family member 16	Homo sapiens	45-48
35198077-7	2022	PPARdelta directly bound to the oxygen-dependent degradation domain of HIF1alpha at the ligand-dependent domain of PPARdelta.	Oxygen	32-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	71-80
22850683-6	2012	In glucose transport and mitochondria oxidation studies using skeletal muscle cells, we found that stable TRIB3 overexpression impaired insulin-stimulated glucose uptake without affecting basal glucose transport and increased both basal glucose oxidation and the maximal uncoupled oxygen consumption rate.	Oxygen	281-287	tribbles pseudokinase 3	Rattus norvegicus	106-111
35058442-11	2022	These results suggest a novel model of tumorigenesis, in which PGK1 switches between repressing autophagy-mediated cell death via PRAS40 and inducing autophagy through Beclin1 according to the environmental oxygen level.	Oxygen	207-213	phosphoglycerate kinase 1	Homo sapiens	63-67
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	30-36	colony stimulating factor 1	Homo sapiens	264-268
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	98-104	colony stimulating factor 1	Homo sapiens	264-268
35115380-7	2022	Finally, hypoxic cell proliferation and myofiber formation in Bmal1-deficient myoblasts are restored by increasing cytosolic NAD+ Together, we identify the MuSC clock as a pivotal regulator of oxygen-dependent myoblast cell fate and muscle repair through the control of the NAD+-driven response to injury.	Oxygen	193-199	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	62-67
34939980-10	2022	Taken together, these results suggest that the MIC-1 produced by melanoma cells in response to oxygen deprivation promotes tumor vascularization during melanoma development in vivo, leading to enhanced tumor growth and metastasis.	Oxygen	95-101	growth differentiation factor 15	Mus musculus	47-52
22850683-7	2012	With stable knockdown of TRIB3, basal and insulin-stimulated glucose transport rates were increased, whereas basal glucose oxidation and the maximal uncoupled oxygen consumption rate were decreased.	Oxygen	159-165	tribbles pseudokinase 3	Rattus norvegicus	25-30
22932316-8	2012	The close proximity of the 5"-carbonyl oxygen atom in 2-7 to the sulfur atom of Met274 in HDAC8 or the corresponding isobutyl group of Leu274 in HDAC1 may attenuate potency through repulsive steric and dipole-dipole forces.	Oxygen	39-45	histone deacetylase 8	Homo sapiens	90-95
35050446-0	2022	Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition.	Oxygen	33-39	HECT domain E3 ubiquitin protein ligase 1	Mus musculus	13-23
35207496-5	2022	Our computation and statistical analysis showed that the protein environment for hemoglobin and myoglobin prominently affects the doming distortion of heme porphyrin, which correlates with its oxygen affinity, and that the magnitude of distortion is different between hemoglobin and myoglobin.	Oxygen	193-199	myoglobin	Homo sapiens	96-105
35128270-7	2022	When the doping amount of BBPMS is 70-80%, the O2/N2 gas permeation separation of the BBPMS/EC/IL ternary composite membrane is close to the Robertson 2008 curve.	Oxygen	47-49	gastrin	Homo sapiens	53-56
35163911-2	2022	It was shown that efficient oxygen diffusion from metal oxides to the clean Fe(111) iron surface took place even at temperatures lower than 100  C. The effective wetting of the iron surface by potassium oxide is possible when the surface is covered with oxygen at temperatures above 250  C. In the TOF-SIMS spectra of the surface of iron wetted with potassium, an emission of secondary FeOK+ ions was observed that implies that potassium atoms are bound to the iron surface atoms through oxygen.	Oxygen	28-34	FEZ family zinc finger 2	Homo sapiens	298-301
35163911-2	2022	It was shown that efficient oxygen diffusion from metal oxides to the clean Fe(111) iron surface took place even at temperatures lower than 100  C. The effective wetting of the iron surface by potassium oxide is possible when the surface is covered with oxygen at temperatures above 250  C. In the TOF-SIMS spectra of the surface of iron wetted with potassium, an emission of secondary FeOK+ ions was observed that implies that potassium atoms are bound to the iron surface atoms through oxygen.	Oxygen	254-260	FEZ family zinc finger 2	Homo sapiens	298-301
35520392-3	2022	Hypoxia-inducible factor (HIF)-1alpha is one of the primary transcription factors responsible for regulating the cellular response to changes in oxygen tension.	Oxygen	145-151	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
35044184-3	2022	The presence of an NFL is facilitated by the weakened electron-electron correlation when the on-site Coulomb repulsion of Co4+ with Na+ and oxygen vacancy with Na+ is balanced.	Oxygen	140-146	complement C4A (Rodgers blood group)	Homo sapiens	122-125
35052472-2	2022	Mutations in the genes coding the alpha and beta globin chains (HBA1, HBA2 and HBB) strengthen the binding of oxygen to hemoglobin (Hb), bringing about tissue hypoxia and a secondary erythrocytosis.	Oxygen	110-116	hemoglobin subunit beta	Homo sapiens	79-82
22539004-8	2012	Inhibition of this phosphorylation prevented Bim expression and protected neurons against excitotoxic and oxygen/glucose deprivation-induced injury.	Oxygen	106-112	BCL2 like 11	Homo sapiens	45-48
35005550-2	2022	Its expression is regulated by two different oxygen sensing systems; HIF1alpha and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia.	Oxygen	45-51	2-aminoethanethiol dioxygenase	Homo sapiens	83-105
35005550-2	2022	Its expression is regulated by two different oxygen sensing systems; HIF1alpha and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia.	Oxygen	45-51	2-aminoethanethiol dioxygenase	Homo sapiens	107-110
35005550-2	2022	Its expression is regulated by two different oxygen sensing systems; HIF1alpha and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia.	Oxygen	45-51	interleukin 32	Homo sapiens	129-134
35163298-8	2022	These data indicate that Nisch null cells have lower oxygen consumption rates, lower ATP production, and lower levels of proton leak.	Oxygen	53-59	nischarin	Mus musculus	25-30
35163207-6	2022	The eukaryotic translation initiation factor 5A is upregulated under respiratory metabolism and its deficiency reduces oxygen consumption, ATP production, and the levels of several mitochondrial metabolic enzymes, as well as altering mitochondria dynamics.	Oxygen	119-125	eukaryotic translation initiation factor 5A	Homo sapiens	4-47
35000393-1	2022	Here, we quantify the effect of an external magnetic field (beta) on the oxygen evolution reaction (OER) for a cobalt oxide fluorine-doped tin oxide coated glass (CoOx FTO) anode.	Oxygen	73-79	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	168-171
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	24-30	CD34 antigen	Mus musculus	183-187
35079622-4	2022	Affected FDX2 individual fibroblasts and myoblasts showed reduced oxygen consumption rates and mitochondrial complex I and PDHc activities, associated with high levels of blood FGF21.	Oxygen	66-72	ferredoxin 2	Homo sapiens	9-13
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	24-30	CD34 antigen	Mus musculus	214-218
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	64-70	CD34 antigen	Mus musculus	183-187
35055073-5	2022	In in vitro, CoCl2-induced chemical hypoxia and 1% O2 ambient hypoxia both reduced FNDC5, along with the increase in HIF-1alpha.	Oxygen	51-53	fibronectin type III domain containing 5	Mus musculus	83-88
35055073-5	2022	In in vitro, CoCl2-induced chemical hypoxia and 1% O2 ambient hypoxia both reduced FNDC5, along with the increase in HIF-1alpha.	Oxygen	51-53	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	64-70	CD34 antigen	Mus musculus	214-218
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	64-70	CD34 antigen	Mus musculus	183-187
34981938-2	2022	These are prepared by cryoreduction/annealing of the parent (LCuI(O2))+ Cu(I) dioxygen adducts with the tripodal, N4-coordinating, tetradentate ligands L = PVtmpa, DMMtmpa, TMG3tren and are best described as (LCuII(O2 -))+ Cu(II) complexes that possess end-on (eta1-O2 -) superoxo coordination.	Oxygen	214-220	secreted phosphoprotein 1	Homo sapiens	261-265
23114143-3	2012	The results showed that oxygen concentrations lower than normal oxygen concentration, especially in hypoxic oxygen environment, could reduce ROS generation and amplify more primitive CD34(+)AC133(+) HSC and active CD34(+) HSC, and maintain more stem cells in the G(0)/G(1) phase, which is more helpful to the growth of CFU-S and viability of mice.	Oxygen	64-70	CD34 antigen	Mus musculus	214-218
22543164-4	2012	Thus, incorporation of Acr(+)-Mes into nanosized mesoporous silica-alumina combined with an O(2)-reduction catalyst ([(tmpa)Cu(II)](2+)) provides a promising method in the development of efficient and robust organic photocatalysts for substrate oxygenation by dioxygen, the ultimate environmentally benign oxidant.	Oxygen	260-268	acrosin	Homo sapiens	23-26
22689962-4	2012	Oxidic Co and Ni borate (Co-B(i) and Ni-B(i)) thin films electrodeposited from solution yield oxygen-evolving catalysts with Tafel slopes of 52 mV/decade and 30 mV/decade, respectively.	Oxygen	94-100	metabolism of cobalamin associated B	Homo sapiens	25-32
35096814-5	2021	Taken together, aberrant expression of SIPA1 resulted in the alteration of glucose metabolism from oxidative phosphorylation to aerobic glycolysis even at ambient oxygen levels, which might aggravate the malignancy of breast cancer cells.	Oxygen	163-169	signal-induced proliferation-associated 1	Homo sapiens	39-44
35006382-0	2022	Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy.	Oxygen	91-97	secretogranin III	Homo sapiens	0-17
35386309-6	2022	They could (1) increase M1-phenotype macrophages at tumor site by promoting the polarization of tumor-associated macrophages through the reactive oxygen species (ROS) and oxygen generated from the Fenton-like reaction between nanoparticles and H2O2 within tumor under NIR II irradiation; (2) decrease the infiltration of Tregs cells at tumor site through the release of IND; (3) decrease the expression of PD-L1 on tumor cells through JQ1.	Oxygen	171-177	CD274 molecule	Homo sapiens	406-411
22689962-4	2012	Oxidic Co and Ni borate (Co-B(i) and Ni-B(i)) thin films electrodeposited from solution yield oxygen-evolving catalysts with Tafel slopes of 52 mV/decade and 30 mV/decade, respectively.	Oxygen	94-100	metabolism of cobalamin associated B	Homo sapiens	2-3
35359144-10	2022	Lin28 inhibition alleviated neurological impairment, manifested by decreased hematoma, oedema, neuronal necrosis, glial cell swelling, intracellular vacuoles and inflammatory cell infiltration, reduced Fe2+ concentration and reactive oxygen species content, and increased glutathione and glutathione peroxidase 4 activity.	Oxygen	234-240	lin-28 homolog A	Mus musculus	0-5
22843101-7	2012	This suggests increased PTOX-mediated alternative electron flow to oxygen in plants exposed to low temperatures.	Oxygen	67-73	Alternative oxidase family protein	Arabidopsis thaliana	24-28
35380174-0	2022	Hyperbaric oxygen therapy in necrotizing soft tissue infections caused by Vibrio species from the Baltic Sea - three clinical cases.	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	105-108
22623621-0	2012	Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.	Oxygen	117-123	gap junction protein, beta 3	Mus musculus	0-11
22623621-0	2012	Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.	Oxygen	117-123	gap junction protein, beta 3	Mus musculus	13-17
22623621-6	2012	Thus, loss of connexin 31 led to different giant cell subtypes which bypass the progenitor regulators Tfap2c and Tpbpa under low oxygen conditions.	Oxygen	129-135	gap junction protein, beta 3	Mus musculus	14-25
22786772-0	2012	Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.	Oxygen	12-18	egl-9 family hypoxia-inducible factor 3	Mus musculus	26-30
22789927-0	2012	Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy.	Oxygen	132-138	ephrin B2	Mus musculus	15-23
22789927-4	2012	METHODS: Genetically manipulated mice with attenuated ephrinB2 reverse signaling (ephrinB2(lacZ/+)), along with wild-type (WT) controls, were exposed to oxygen-induced retinopathy (OIR), a postnatal model of proliferative retinopathy.	Oxygen	153-159	ephrin B2	Mus musculus	82-90
22747342-6	2012	Time-resolved LIF intensities of O2(X3Sigma(-)g, v) at various pressures of O2 and fixed pressure of CF4 were recorded.	Oxygen	33-35	LIF interleukin 6 family cytokine	Homo sapiens	14-17
22706208-0	2012	Bacterioferritin protects the anaerobe Desulfovibrio vulgaris Hildenborough against oxygen.	Oxygen	84-90	bfr	Desulfovibrio vulgaris str. Hildenborough	0-16
22706208-5	2012	When grown in the presence of high concentrations of oxygen the D. vulgaris bacterioferritin mutant exhibited, in comparison with the wild type strain, lower viability and a higher content of intracellular reactive oxygen species.	Oxygen	53-59	bfr	Desulfovibrio vulgaris str. Hildenborough	76-92
22706208-7	2012	Altogether the data revealed a previously unrecognized ability for the iron storage bacterioferritin to contribute to the oxygen tolerance exhibited by D. vulgaris.	Oxygen	122-128	bfr	Desulfovibrio vulgaris str. Hildenborough	84-100
22739762-6	2012	RESULTS: This study indicates that scO2 is influenced by skin oxygen saturation because whole-body heating increased scO2 by 3.6% (2.1-5.1%; 95% CI) and skin oxygen saturation by 3.1% (1.3-4.9%), whereas scapO2 remained unaffected.	Oxygen	62-68	synthesis of cytochrome C oxidase 2	Homo sapiens	35-39
22739762-6	2012	RESULTS: This study indicates that scO2 is influenced by skin oxygen saturation because whole-body heating increased scO2 by 3.6% (2.1-5.1%; 95% CI) and skin oxygen saturation by 3.1% (1.3-4.9%), whereas scapO2 remained unaffected.	Oxygen	62-68	synthesis of cytochrome C oxidase 2	Homo sapiens	117-121
22739762-6	2012	RESULTS: This study indicates that scO2 is influenced by skin oxygen saturation because whole-body heating increased scO2 by 3.6% (2.1-5.1%; 95% CI) and skin oxygen saturation by 3.1% (1.3-4.9%), whereas scapO2 remained unaffected.	Oxygen	158-164	synthesis of cytochrome C oxidase 2	Homo sapiens	35-39
22229392-9	2012	C57Bl6 mice exposed to 90%-100% O(2) for 45 min+-mechanical ventilation had increased PA PDE5 activity (206+-39% and 235+-75%, respectively).	Oxygen	32-36	phosphodiesterase 5A, cGMP-specific	Mus musculus	89-93
22838397-6	2012	The constitutive phenotype originated from deletions in the FLO5 promoter region, indicating the existence of putative upstream repressor site involved in oxygen regulation of the EPG1 promoter.	Oxygen	155-161	flocculin FLO5	Saccharomyces cerevisiae S288C	60-64
22692585-1	2012	The catalytic durability of an organic photocatalyst, 9-mesityl-10-methyl acridinium ion (Acr(+)-Mes), has been dramatically improved by the addition of [{tris(2-pyridylmethyl)amine}Cu(II)](ClO(4))(2) ([(tmpa)Cu(II)](2+)) in the photocatalytic oxygenation of p-xylene by molecular oxygen in acetonitrile.	Oxygen	244-250	acrosin	Homo sapiens	90-93
22692585-6	2012	The reaction of O(2) (-) with [(tmpa)Cu(II)](2+) monitored by UV-vis spectroscopy in propionitrile at 203 K suggested formation of [{(tmpa)Cu(II)}(2)O(2)](2+), a transformation which is crucial for the overall 4-electron reduction of molecular O(2) to water, and a key in the observed improvement in the catalytic durability of Acr(+)-Mes.	Oxygen	16-24	acrosin	Homo sapiens	328-331
22648409-3	2012	Sequences related to DdPhyA, DdSkp1, and the glycosyltransferases that cap Skp1 hydroxyproline occur also in the genomes of Toxoplasma and other protists, suggesting that this O(2) sensing mechanism may be widespread.	Oxygen	176-180	S-phase kinase associated protein 1	Homo sapiens	31-35
22648409-10	2012	The findings suggest that Skp1 hydroxylation by PhyA is a conserved process among protists and that this biochemical pathway may indirectly sense O(2) by detecting the levels of O(2)-regulated metabolites such as alpha-ketoglutarate.	Oxygen	146-150	S-phase kinase associated protein 1	Homo sapiens	26-30
22648409-10	2012	The findings suggest that Skp1 hydroxylation by PhyA is a conserved process among protists and that this biochemical pathway may indirectly sense O(2) by detecting the levels of O(2)-regulated metabolites such as alpha-ketoglutarate.	Oxygen	178-182	S-phase kinase associated protein 1	Homo sapiens	26-30
22593272-5	2012	Exposure to a low oxygen concentration (1%) increased gastrin mRNA concentrations in wild-type AGS cells (AGS) and in AGS cells overexpressing the gastrin receptor (AGS-cholecystokinin receptor 2) by 2.1 +- 0.4- and 4.1 +- 0.3-fold (P &lt; 0.05), respectively.	Oxygen	18-24	gastrin	Homo sapiens	54-61
22580202-0	2012	Protective effects of XBP1 against oxygen and glucose deprivation/reoxygenation injury in rat primary hippocampal neurons.	Oxygen	35-41	X-box binding protein 1	Rattus norvegicus	22-26
21997676-5	2012	For EAP 1 and 2, 100% O(2) was used for the end stage of decompression, with a 30% reduction of decompression time in EAP 1 and 50% in EAP 2, compared to the French navy standard schedule.	Oxygen	22-26	tyrosyl-DNA phosphodiesterase 2	Homo sapiens	135-140
23005226-10	2012	We find a somewhat lower melting temperature for the oxygen-selenium system than that predicted by Medin and Cumming.	Oxygen	53-59	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	99-104
22424133-8	2012	Under hypoxic conditions, lack of oxygen causes hydroxylation to cease HIF-1alpha stabilization and subsequent translocation to the nucleus where it heterodimerizes with the constitutively expressed beta subunit.	Oxygen	34-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	71-81
22588718-4	2012	By reducing steady-state levels of ER Ca2+ via IP3Rs, BI-1 influences mitochondrial bioenergetics, reducing oxygen consumption, impacting cellular ATP levels, and stimulating autophagy.	Oxygen	108-114	transmembrane BAX inhibitor motif containing 6	Mus musculus	54-58
22588718-7	2012	The results reveal BI-1 as a novel autophagy regulator that bridges Ca2+ signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress.	Oxygen	130-136	transmembrane BAX inhibitor motif containing 6	Mus musculus	19-23
22366847-10	2012	There was a significant correlation between oxygen desaturation index (ODI, hourly average number of desaturation episodes) and cumulative time percentage with SpO(2) &lt;90% (CT90) from nocturnal oximetry, with the parameters measuring sleep breathing disorders from PSG.	Oxygen	44-50	kinesin family member 20B	Homo sapiens	176-180
22539295-2	2012	Hypoxia-inducible transcription factor (HIF)1alpha is responsible for major alterations in gene expression as part of the cellular adaptation to low oxygen concentration.	Oxygen	149-155	hypoxia inducible factor 1, alpha subunit	Mus musculus	40-50
22539295-8	2012	Taken together, our data indicate that HIF1alpha plays an important role for DC differentiation and migration in a low oxygen environment.	Oxygen	119-125	hypoxia inducible factor 1, alpha subunit	Mus musculus	39-48
22362405-1	2012	A mathematical model describing facilitation of O(2) diffusion by the diffusion of myoglobin and hemoglobin is presented.	Oxygen	48-52	myoglobin	Homo sapiens	83-92
22362405-8	2012	Although the "O(2) transport function" of myoglobin in cardiac muscle cells thus is severely limited by the chemical reaction kinetics, and to a lesser extent also in skeletal muscle, it is noteworthy that the speed of release of O(2) from MbO(2), the "storage function," is not limited by the reaction kinetics under physiological conditions.	Oxygen	14-18	myoglobin	Homo sapiens	42-51
22362405-8	2012	Although the "O(2) transport function" of myoglobin in cardiac muscle cells thus is severely limited by the chemical reaction kinetics, and to a lesser extent also in skeletal muscle, it is noteworthy that the speed of release of O(2) from MbO(2), the "storage function," is not limited by the reaction kinetics under physiological conditions.	Oxygen	230-234	myoglobin	Homo sapiens	42-51
22402262-4	2012	The ZTL/FKF1/LKP2 protein family possesses a unique combination of domains: a blue-light-absorbing LOV (Light, Oxygen, or Voltage) domain along with domains involved in protein degradation.	Oxygen	111-117	flavin-binding, kelch repeat, f box 1	Arabidopsis thaliana	8-12
22539857-10	2012	Because EPO expression is hypoxia sensitive, it may play a role in respiratory plasticity in conditions of prolonged or recurrent low oxygen.	Oxygen	134-140	erythropoietin	Rattus norvegicus	8-11
22318951-4	2012	We report that lack of mstn induced a decrease in the coupling of IMF mitochondria respiration, with significantly higher basal oxygen consumption.	Oxygen	128-134	myostatin	Mus musculus	23-27
23576844-7	2012	Mb in the films displayed good electrocatalytic activities towards various substrates such as hydrogen peroxide, nitrite and oxygen, indicating that the composite films have potential applications in fabricating novel biosensors without using mediators.	Oxygen	125-131	myoglobin	Homo sapiens	0-2
22405203-0	2012	CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.	Oxygen	26-28	Cysteine synthase 1	Caenorhabditis elegans	0-6
22180657-10	2012	This early hyperoxic exposure, from normal ambient and supplemental oxygen, would presumably inhibit normal hypoxia inducible factor-1alpha signaling, mimicking the functional deletion described.	Oxygen	68-74	hypoxia inducible factor 1, alpha subunit	Mus musculus	108-139
22205687-6	2012	The degradation and activity of HIF-1alpha and HIF-2alpha are tightly controlled by the fine-tuned action of oxygen-sensing prolyl and asparaginyl hydroxylase enzymes.	Oxygen	109-115	endothelial PAS domain protein 1	Homo sapiens	47-57
22219185-4	2012	FHL1-3 inhibit HIF-1 transcriptional activity and HIF-1alpha transactivation domain function by oxygen-independent mechanisms.	Oxygen	96-102	four and a half LIM domains 1	Homo sapiens	0-4
22268528-4	2012	Hydrogen bonding interaction is found to occur between the protons at C-2 on the imidazolium ring and the oxygen atoms in [NO(3)](-) anions, and the interaction varies as a function of the basicity of the counterions and the hydrophobicity of the side-chains bonded to the imidizolium ring.	Oxygen	106-112	complement C2	Homo sapiens	70-73
22354010-3	2012	Recently we have shown that inhibition of the oxygen sensor PHD2 in tumor cells blocks tumor growth due to the anti-proliferative activity of TGFbeta.	Oxygen	46-52	egl-9 family hypoxia-inducible factor 1	Mus musculus	60-64
22196056-5	2012	In the current study, we used QM/MM methods to decipher the mechanism by which the second ferryl oxygen is inserted into the Trp-epoxide to form the NFK product in hIDO.	Oxygen	97-103	indoleamine 2,3-dioxygenase 1	Homo sapiens	164-168
22196056-9	2012	The results underscore the importance of the NH(3)(+) group of Trp in the two-step ferryl-based mechanism of hIDO and xcTDO, by acting as an acid catalyst to facilitate the epoxide ring-opening reaction and ferryl oxygen addition to the indole ring.	Oxygen	214-220	indoleamine 2,3-dioxygenase 1	Homo sapiens	109-113
22106416-9	2012	Analysis of the link between sAC and apoptosis revealed a sAC and protein kinase A-dependent Bax phosphorylation at Thr(167) and its translocation to mitochondria during SI, which subsequently caused mitochondrial oxygen radical formation followed by cytochrome c release and caspase-9 cleavage during SR.	Oxygen	214-220	adenylate cyclase 10	Rattus norvegicus	29-32
22106416-9	2012	Analysis of the link between sAC and apoptosis revealed a sAC and protein kinase A-dependent Bax phosphorylation at Thr(167) and its translocation to mitochondria during SI, which subsequently caused mitochondrial oxygen radical formation followed by cytochrome c release and caspase-9 cleavage during SR.	Oxygen	214-220	adenylate cyclase 10	Rattus norvegicus	58-61
22106416-9	2012	Analysis of the link between sAC and apoptosis revealed a sAC and protein kinase A-dependent Bax phosphorylation at Thr(167) and its translocation to mitochondria during SI, which subsequently caused mitochondrial oxygen radical formation followed by cytochrome c release and caspase-9 cleavage during SR.	Oxygen	214-220	BCL2 associated X, apoptosis regulator	Rattus norvegicus	93-96
21614506-12	2012	We concluded that chronic CaMKII inhibition increased time to 50% re-lengthening which were recovered by exercise training, but paradoxically led to a greater increase in maximal oxygen uptake compared to sham mice.	Oxygen	179-185	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	26-32
22172337-5	2012	RESULTS: Exposure of LNCaP cells to low oxygen tension induced a neuroendocrine phenotype, associated with an increased expression of the transcription factor neurogenin3 and neuroendocrine markers, such as neuron-specific enolase, chromogranin A, and beta3-tubulin.	Oxygen	40-46	neurogenin 3	Homo sapiens	159-170
22472890-5	2012	An increased hypoxia inducible factor-1alpha (HIF-1alpha) translocation and vascular endothelial growth factor (VEGF) expression has been found upon 95% oxygen exposure to induce morphological modifications.	Oxygen	153-159	vascular endothelial growth factor A	Rattus norvegicus	76-110
22472890-5	2012	An increased hypoxia inducible factor-1alpha (HIF-1alpha) translocation and vascular endothelial growth factor (VEGF) expression has been found upon 95% oxygen exposure to induce morphological modifications.	Oxygen	153-159	vascular endothelial growth factor A	Rattus norvegicus	112-116
22237207-6	2012	Here, we report that elevated oxygen (hyperoxia) triggers a marked increase in active caspase-2 expression, resulting in an initiation of the intrinsic apoptotic pathway with upregulation of key proteins, namely, cytochrome c, apoptosis protease-activating factor-1, and the caspase-independent protein apoptosis-inducing factor, whereas BH3-interacting domain death agonist and the anti-apoptotic protein B-cell lymphoma-2 are downregulated.	Oxygen	30-36	caspase 2	Homo sapiens	86-95
22200182-2	2012	The M2 tumor-specific isoform of pyruvate kinase (PKM2) promotes glucose uptake and lactate production in the presence of oxygen, known as aerobic glycolysis or the Warburg effect.	Oxygen	122-128	pyruvate kinase M1/2	Homo sapiens	50-54
24391275-1	2012	The mesopelagic zone of the Red Sea represents an extreme environment due to low food concentrations, high temperatures and low oxygen waters.	Oxygen	128-134	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
23353840-13	2012	This ligand orientation is in CYP1A1/1A2 further stabilized by two hydrogen bonds; one between an oxygen atom of the AAI nitro-group and the hydroxyl group of Ser122/Thr124; and the second bond between an oxygen atom of dioxolane ring of AAI and the hydroxyl group of Thr497/Thr498.	Oxygen	98-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
23353840-13	2012	This ligand orientation is in CYP1A1/1A2 further stabilized by two hydrogen bonds; one between an oxygen atom of the AAI nitro-group and the hydroxyl group of Ser122/Thr124; and the second bond between an oxygen atom of dioxolane ring of AAI and the hydroxyl group of Thr497/Thr498.	Oxygen	205-211	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
22086331-2	2012	Here, we report the rapid and transient activation of MPK3, MPK4 and MPK6 upon oxygen deprivation as well as reoxygenation in seedlings of Arabidopsis thaliana.	Oxygen	79-85	MAP kinase 4	Arabidopsis thaliana	60-64
22086331-8	2012	We found that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3, MPK4 and MPK6, but the induction of mRNAs associated with low oxygen acclimation responses were not markedly altered in MPK6 overexpression lines or mpk6 loss-of-function mutants.	Oxygen	45-51	MAP kinase 4	Arabidopsis thaliana	127-131
23226323-4	2012	Nuclear accumulation of annexin A2 is blocked by the antioxidant agent N-acetyl cysteine (NAC) and stimulated by hydrogen peroxide (H2O2), suggesting that this is a reactive oxygen species dependent event.	Oxygen	174-180	annexin A2	Homo sapiens	24-34
22937109-6	2012	Expression of MyoD in primary myoblasts was delayed at 20% oxygen, but myogenicity, as measured by fusion index, was slightly higher.	Oxygen	59-65	myogenic differentiation 1	Mus musculus	14-18
22911720-6	2012	Our study clearly demonstrated that SAQ is a highly efficient oxidative engine, which shows high efficiency in the de novo disulfide formation and oxygen reduction and that this more efficient oxidative engine is necessary for the highly efficient catalysis of QSOXs compared to Erv1 and Erv2.	Oxygen	147-153	growth factor, augmenter of liver regeneration	Homo sapiens	279-283
22792172-1	2012	Previously, we showed that insulin growth factor (IGF)-1 binding protein-3 (IGFBP-3), independent of IGF-1, reduces pathological angiogenesis in a mouse model of the oxygen-induced retinopathy (OIR).	Oxygen	166-172	insulin-like growth factor binding protein 3	Mus musculus	76-83
22339027-6	2012	The result of long-term experiments showed that the chemical oxygen demand (COD) of NF90 permeates was below 70 mg/L consistently and the wastewater could be concentrated to 24% by a two-stage membrane process.	Oxygen	61-67	interleukin enhancer binding factor 3	Homo sapiens	84-88
21930697-2	2011	The positive correlation with hypoxia-inducible factor 2alpha (HIF-2alpha) and carbonic anhydrase IX suggested that oxygen regulates myoglobin expression in breast carcinomas.	Oxygen	116-122	endothelial PAS domain protein 1	Homo sapiens	30-61
21930697-2	2011	The positive correlation with hypoxia-inducible factor 2alpha (HIF-2alpha) and carbonic anhydrase IX suggested that oxygen regulates myoglobin expression in breast carcinomas.	Oxygen	116-122	endothelial PAS domain protein 1	Homo sapiens	63-73
21930697-2	2011	The positive correlation with hypoxia-inducible factor 2alpha (HIF-2alpha) and carbonic anhydrase IX suggested that oxygen regulates myoglobin expression in breast carcinomas.	Oxygen	116-122	myoglobin	Homo sapiens	133-142
21930697-6	2011	Functionally, the knockdown of MB in MDA-MB468 breast cancer cells resulted in an unexpected increase of O(2) uptake and elevated activities of mitochondrial enzymes during hypoxia.	Oxygen	105-109	myoglobin	Homo sapiens	31-33
21930697-9	2011	This control function of MB seemingly impacts mitochondria and influences cell proliferation and motility, but it does so in ways not directly related to the facilitated diffusion or storage of O(2).	Oxygen	194-198	myoglobin	Homo sapiens	25-27
21659659-9	2011	In newborn rats, exposure to 90% oxygen for 14 days resulted in activation of beta-catenin signaling, decreased alveolarization and vascular development, and physiological and histological evidence of pulmonary hypertension (PH).	Oxygen	33-39	catenin beta 1	Rattus norvegicus	78-90
21964931-4	2011	Here, we show that Rg1 is an effective stimulator of HIF-1alpha under normal cellular oxygen conditions in human umbilical vein endothelial cells.	Oxygen	86-92	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	19-22
22195399-1	2011	Some manufacturers of reduced oxygen (O2) breathing devices claim a comparable hypobaric hypoxia (HH) training experience by providing F1O2 &lt; 0.209 at or near sea level pressure to match the ambient oxygen partial pressure (iso-PO2) of the target altitude.	Oxygen	38-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	162-165
21782983-1	2011	Myoglobin (Mb), the main cytosolic oxygen storage/deliver protein, is also known to interact with different small ligands exerting other fundamental physiological roles.	Oxygen	35-41	myoglobin	Homo sapiens	0-9
22243227-3	2011	In the present study we investigated, in a mouse mesenchymal C3H10T1/2 stem cell model, the hypothesis that oxygen stress modulates tuftelin 1 expression in relation to HIF-1-alpha (Hif1a), in a mouse mesenchymal C3H10T1/2 stem cell model.	Oxygen	108-114	hypoxia inducible factor 1, alpha subunit	Mus musculus	169-180
22243227-3	2011	In the present study we investigated, in a mouse mesenchymal C3H10T1/2 stem cell model, the hypothesis that oxygen stress modulates tuftelin 1 expression in relation to HIF-1-alpha (Hif1a), in a mouse mesenchymal C3H10T1/2 stem cell model.	Oxygen	108-114	hypoxia inducible factor 1, alpha subunit	Mus musculus	182-187
21284409-5	2011	It describes that heteroatoms (oxygen atom connected with carbon atom) in the molecules are favourable for alpha-glucosidase inhibitory activity.	Oxygen	31-37	sucrase-isomaltase	Homo sapiens	107-124
22338317-5	2011	Because C-17 aircraft have a built-in medical oxygen supply, transcontinental patient transport using HFPV has become feasible.	Oxygen	46-52	cytokine like 1	Homo sapiens	8-12
21868707-1	2011	OBJECTIVE: Pericytes/pericyte precursors produce milk fat globule-associated protein with epidermal growth factor and factor VIII-like domains (MFG-E8) in vivo, and this alpha(v) integrin ligand enhances angiogenesis in tumors and in oxygen-induced retinopathy in mice.	Oxygen	234-240	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	144-150
21872926-7	2011	TNF-R1 levels measured in placental homogenate increased up to 2-fold at both O(2) concentrations, but were significantly lower (1.96 fold; p = 0.03) at 6% O(2) compared to 20% O(2).	Oxygen	78-82	TNF receptor superfamily member 1A	Homo sapiens	0-6
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	106-112	endothelial PAS domain protein 1	Homo sapiens	54-63
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	170-176	endothelial PAS domain protein 1	Homo sapiens	54-63
22223045-3	2011	We compared the transcriptional activity of HIF1alpha/HIF2alpha mutants that obtained their resistance to oxygen-dependent degradation either by deletion of their entire oxygen-dependent degradation (ODD) domain or by replacement of prolyl residues that are crucial for oxygen-dependent degradation.	Oxygen	170-176	endothelial PAS domain protein 1	Homo sapiens	54-63
21964330-6	2011	Surprisingly, when concentrations of S-nitrosothiols were high, nitric oxide function also governed a negative feedback loop limiting the hypersensitive response, mediated by S-nitrosylation of the NADPH oxidase, AtRBOHD, at Cys 890, abolishing its ability to synthesize reactive oxygen intermediates.	Oxygen	280-286	NADPH oxidase	Drosophila melanogaster	198-211
21989061-7	2011	In vitro HIF-1alpha bioluminescence assay is performed by incubating the transfected cells in a hypoxic chamber (0.1% O2) for 24 hr before BLI, while the cells in normoxia (21% O2) serve as a control.	Oxygen	118-120	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-19
21989061-7	2011	In vitro HIF-1alpha bioluminescence assay is performed by incubating the transfected cells in a hypoxic chamber (0.1% O2) for 24 hr before BLI, while the cells in normoxia (21% O2) serve as a control.	Oxygen	177-179	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-19
21784985-0	2011	Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.	Oxygen	24-30	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	89-93
21784985-2	2011	In the present study, we used a genetic model to investigate the physiological functions of SUR2-containing K(ATP) channels in mediating vasodilation to hypoxia, oxygen and glucose deprivation (OGD) or metabolic inhibition, and functional recovery following these insults.	Oxygen	162-168	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	92-96
21784985-8	2011	The restoration of oxygen and glucose following OGD or removal of oligomycin B and CCCP resulted in partial recovery of tone in both SUR2(wt) and SUR2(nl) cerebral arteries.	Oxygen	19-25	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	133-137
21784985-8	2011	The restoration of oxygen and glucose following OGD or removal of oligomycin B and CCCP resulted in partial recovery of tone in both SUR2(wt) and SUR2(nl) cerebral arteries.	Oxygen	19-25	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	146-150
21703224-5	2011	At pH 6.9, (1)H-NMR spectrum of deoxy-Hb in the presence of L35 and IHP showed a marker of the T-quaternary structure (the T-marker) at 14ppm, originated from inter- dimeric alpha(1)beta(2)- (or alpha(2)beta(1)-) hydrogen-bonds, and hyperfine-shifted (hfs) signals around 15-25ppm, caused by high-spin heme-Fe(II)s. Upon addition of O(2), the hfs signals disappeared, reflecting that the heme-Fe(II)s are ligated with O(2), but the T-marker signals still remained, although slightly shifted and broadened, under the partial pressure of O(2) (P(O2)) of 760mmHg.	Oxygen	544-546	ribosomal protein L35	Homo sapiens	60-63
21703224-6	2011	These NMR results accompanying with visible absorption spectroscopy and visible resonance Raman spectroscopy reveal that oxy-Hb in the presence of L35 and IHP below pH 7 takes the ligated T-quaternary structure under the P(O2) of 760mmHg.	Oxygen	223-225	ribosomal protein L35	Homo sapiens	147-150
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	catenin beta 1	Homo sapiens	99-111
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	POU class 5 homeobox 1	Homo sapiens	116-120
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	catenin beta 1	Homo sapiens	186-198
21705075-15	2011	The low oxygen level induced HIF1alpha expression, which resulted in increased expression of Wnt5A/beta-catenin and Oct4 via the direct binding of HIF1alpha to the regulatory regions of beta-catenin and Oct4.	Oxygen	8-14	POU class 5 homeobox 1	Homo sapiens	203-207
21913155-5	2011	As expected, peak oxygen uptake presented a direct relationship with mean swimming speed of the first 50-m lap and with the 200-m effort, and was also correlated with the amplitude of the fast component (r=0.75, r=0.72, r=0.73, p&lt;0.05, respectively).	Oxygen	18-24	LAP	Homo sapiens	107-110
21912348-5	2011	Our analysis revealed significant agreement between the in-vitro and in-vivo results showing that all genes except Mitf were hypoxia regulated in the oxygen-deprived tumor regions (P&lt;0.05).	Oxygen	150-156	melanocyte inducing transcription factor	Homo sapiens	115-119
22024847-10	2011	CONCLUSIONS: Sinonasal epithelial CFTR and TMEM16A-mediated Cl(-)  transport and mRNA expression were robustly decreased in an oxygen-restricted environment.	Oxygen	127-133	anoctamin 1	Homo sapiens	43-50
2514602-4	1989	In the presence of 1.8 mM Ca2+, the rate of glycogen breakdown was increased by theophylline in a dose-dependent manner and the dose-response curve was somewhat similar to that obtained with oxygen uptake.	Oxygen	191-197	carbonic anhydrase 2	Homo sapiens	26-29
2514602-8	1989	The Ca2+ ionophore A23187 significantly stimulated the rate of oxygen uptake and this response was not blocked by omeprazole and Sch 28080, two specific inhibitors of gastric H(+)-K(+)-ATPase.	Oxygen	63-69	carbonic anhydrase 2	Homo sapiens	4-7
21873205-3	2011	Sirt3 knockout mice exhibit decreased oxygen consumption and develop oxidative stress in skeletal muscle, leading to JNK activation and impaired insulin signaling.	Oxygen	38-44	sirtuin 3	Mus musculus	0-5
21690092-2	2011	This reaction led to the formation of the dioxygen adduct of IDO and supported the oxidation of Trp to N-formylkynurenine.	Oxygen	42-50	indoleamine 2,3-dioxygenase 1	Homo sapiens	61-64
9991626-0	1989	Desorption of positive oxygen ions induced by keV heavy-ion bombardment of transition metals with adsorbed O2 and CO.	Oxygen	23-29	immunoglobulin kappa variable 1D-39	Homo sapiens	107-116
2808397-5	1989	Activation volumes for O2 to the iron binding step as well as for the O2 diffusion step within the protein matrix were quite different among three Mb species, and it was suggested that activation volumes are very sensitive to the amino acid constituents around the ligand path channel.	Oxygen	23-25	myoglobin	Canis lupus familiaris	147-149
2808397-5	1989	Activation volumes for O2 to the iron binding step as well as for the O2 diffusion step within the protein matrix were quite different among three Mb species, and it was suggested that activation volumes are very sensitive to the amino acid constituents around the ligand path channel.	Oxygen	70-72	myoglobin	Canis lupus familiaris	147-149
2511768-5	1989	Insulin infusion resulted in increased plasma insulin, decreased plasma glucose, and decreased oxygen saturation values.	Oxygen	95-101	LOC105613195	Ovis aries	0-7
21680741-11	2011	The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2).	Oxygen	43-49	complement C4A (Rodgers blood group)	Homo sapiens	281-284
2480193-4	1989	Despite enhanced ventilatory function, arterial O2 delivery was markedly reduced by hemorrhage, an effect that was due entirely to decrements in cardiac output and hemoglobin level.	Oxygen	48-50	HGB	Sus scrofa	164-174
2605311-2	1989	Reduction of the pyridoxylated HbAo in the oxygen-ligated form by sodium borohydride gives unacceptable levels of methemoglobin (i.e., greater than 10%).	Oxygen	43-49	hemoglobin subunit gamma 2	Homo sapiens	114-127
21680741-11	2011	The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2).	Oxygen	43-49	formin 1	Homo sapiens	297-300
21561530-3	2011	Among these pathways, evidence has directly pointed to the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway, whose activation resulted in tolerance to the absence of nutrients and oxygen when tumor angiogenesis has been inhibited.	Oxygen	184-190	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	94-102
2478233-3	1989	The CD14+/CD16+ cells can be assigned to the monocyte lineage based on typical morphology, on expression of additional monocyte-associated molecules, on the ability to form reactive oxygen intermediates and on the expression of monocyte-specific NaF-sensitive esterase.	Oxygen	182-188	Fc gamma receptor IIIa	Homo sapiens	10-14
2678404-7	1989	Less severe oxygen desaturation occurred during non-rapid-eye-movement sleep on the nasal CPAP and ESAP nights.	Oxygen	12-18	centromere protein J	Homo sapiens	90-94
21701263-4	2011	Here, we demonstrate that siRNA oligonucleotides targeting the mRNA surveillance proteins SMG1, Upf1, Upf2, or the PIKK protein ATM attenuated p53 (ser15) phosphorylation in cells damaged by high oxygen (hyperoxia), a model of persistent oxidative stress that damages nucleotides.	Oxygen	196-202	UPF1 RNA helicase and ATPase	Homo sapiens	96-100
2819035-15	1989	In horse alcohol dehydrogenase and beta 1 beta 1, the guanidino group of Arg-369 is thought to stabilize the NAD(H)-enzyme complex by bonding to one of the pyrophosphate oxygens.	Oxygen	170-177	aldo-keto reductase family 1 member A1	Homo sapiens	9-30
10040733-0	1989	Spin dynamics at oxygen sites in YBa2Cu3O7.	Oxygen	17-23	spindlin 1	Homo sapiens	0-4
2807521-3	1989	The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.	Oxygen	74-76	albumin	Rattus norvegicus	42-49
21701263-4	2011	Here, we demonstrate that siRNA oligonucleotides targeting the mRNA surveillance proteins SMG1, Upf1, Upf2, or the PIKK protein ATM attenuated p53 (ser15) phosphorylation in cells damaged by high oxygen (hyperoxia), a model of persistent oxidative stress that damages nucleotides.	Oxygen	196-202	ATM serine/threonine kinase	Homo sapiens	128-131
21497193-0	2011	Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system.	Oxygen	64-70	catenin beta 1	Homo sapiens	31-43
2584778-12	1989	In experimental studies using 20 monkeys (Macaca fascicularis), continuous intraaortic infusion with O2 bubbled autologous blood increased C4a and C3a levels, while autologous blood extracorporeally contacted with nylon increased C3a levels alone.	Oxygen	101-103	complement C3	Homo sapiens	147-150
2771902-7	1989	In sarcoidosis there is a positive correlation between the oxygen radical release of AM and the CD4/CD8 ratio of BAL lymphocytes.	Oxygen	59-65	CD8a molecule	Homo sapiens	100-103
2584778-12	1989	In experimental studies using 20 monkeys (Macaca fascicularis), continuous intraaortic infusion with O2 bubbled autologous blood increased C4a and C3a levels, while autologous blood extracorporeally contacted with nylon increased C3a levels alone.	Oxygen	101-103	complement C3	Homo sapiens	230-233
21540300-9	2011	RORalpha(sg/sg) mice consumed more oxygen and produced more carbon dioxide, suggesting increased energy expenditure in this genotype.	Oxygen	35-41	RAR-related orphan receptor alpha	Mus musculus	0-8
2584778-14	1989	In vitro studies revealed that human immunoglobulin denatured by O2 bubbling produced C4a, C3a, and C5a in a dose dependent manner, although human albumin treated identically as human immunoglobulin did not produce them.	Oxygen	65-67	complement C3	Homo sapiens	91-94
2769506-6	1989	We found that (1) total pulmonary resistance, significantly higher in infants with bronchopulmonary dysplasia than in control infants, decreased from 206.1 +/- 47 cm H2O.L-1.sec-1 during inhalation of room air to 106.5 +/- 20.9 during inhalation of 100% oxygen (p less than 0.05) and (2) pulmonary dynamic compliance, lower in infants with bronchopulmonary dysplasia than in control infants, increased significantly with the administration of 100% oxygen.	Oxygen	254-260	secretory blood group 1, pseudogene	Homo sapiens	174-179
2769506-6	1989	We found that (1) total pulmonary resistance, significantly higher in infants with bronchopulmonary dysplasia than in control infants, decreased from 206.1 +/- 47 cm H2O.L-1.sec-1 during inhalation of room air to 106.5 +/- 20.9 during inhalation of 100% oxygen (p less than 0.05) and (2) pulmonary dynamic compliance, lower in infants with bronchopulmonary dysplasia than in control infants, increased significantly with the administration of 100% oxygen.	Oxygen	448-454	secretory blood group 1, pseudogene	Homo sapiens	174-179
2769749-12	1989	The inhibitor polyols are bound in the active site in an extended open chain conformation and complete an octahedral co-ordination shell for the magnesium cation via their oxygen atoms O-2 and O-4.	Oxygen	172-178	immunoglobulin kappa variable 1D-39	Homo sapiens	185-196
2630100-2	1989	The respiratory control ratio (RCR) decreased by 50% on addition of 20 microM pentagalloylglucose to highly coupled mitochondria, but the adenosine-5"-diphosphate/oxygen (ADP/O) ratio decreased only slightly.	Oxygen	163-169	seminal vesicle secretory protein 4	Rattus norvegicus	171-176
21540340-9	2011	mRNA levels of the elastolytic enzyme, matrix metalloproteinase-2 (MMP-2) were inversely correlated with fetal arterial oxygen saturation (P &lt;0.05) (Fig.	Oxygen	120-126	72 kDa type IV collagenase	Ovis aries	39-65
2539390-4	1989	Since xanthine oxidase is known to generate .O2- in reperfused ischemic tissue and in certain inflammatory disorders, we attempted to assess its role in porphyrin photosensitization.	Oxygen	45-47	xanthine dehydrogenase	Mus musculus	6-22
2918503-0	1989	Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.	Oxygen	66-72	thymidylate synthase	Mus musculus	23-43
2671703-4	1989	Our work with xanthine/xanthine-oxidase as an extracellular source of active oxygen (AO) and promotable (clone 41) and non-promotable (clone 30) mouse epidermal cells JB6 allows insights into the mechanism of action of oxidant promoters.	Oxygen	77-83	xanthine dehydrogenase	Mus musculus	23-39
2515562-0	1989	[Effect of hyperbaric oxygen therapy on the binding of C-14 arachidonic acid by platelets from diabetic rats].	Oxygen	22-28	anti-Mullerian hormone receptor type 2	Rattus norvegicus	55-59
2914888-3	1989	We have recently proposed a covalent catalytic mechanism for LCAT in which lecithin cleavage proceeds via the formation of a transition state tetrahedral adduct between the oxygen atom of the catalytic serine residue and the sn-2-carbonyl carbon atom of the substrate (Jauhiainen, M., Ridgway, N.D., and Dolphin, P.J.	Oxygen	173-179	lecithin-cholesterol acyltransferase	Homo sapiens	61-65
21540340-9	2011	mRNA levels of the elastolytic enzyme, matrix metalloproteinase-2 (MMP-2) were inversely correlated with fetal arterial oxygen saturation (P &lt;0.05) (Fig.	Oxygen	120-126	72 kDa type IV collagenase	Ovis aries	67-72
21245414-9	2011	Physiological and genetic studies revealed that the IMS domain of Pam18 is required for efficient growth under anaerobic conditions, even though it is dispensable when oxygen is present.	Oxygen	168-174	Pam18p	Saccharomyces cerevisiae S288C	66-71
2928087-4	1989	Infusion of adenosine deaminase (2-4 IU/ml), or 8-phenyltheophylline (5 microM), into stimulated hearts augmented the increase in heart rate by 40-45%, rate-pressure product by 18-20%, and oxygen consumption by 50-55%.	Oxygen	189-195	adenosine deaminase	Rattus norvegicus	12-31
2648673-5	1989	Relatively low levels of methemoglobin could complicate concomitant carbon monoxide poisoning by additive or synergistic effects on oxygen binding and delivery.	Oxygen	132-138	hemoglobin subunit gamma 2	Homo sapiens	25-38
22069743-5	2011	Furthermore, we established a powerful yeast bioassay for RTA in vivo uptake and trafficking which is based on the measurement of dissolved oxygen in toxin-treated spheroplast cultures of S. cerevisiae.	Oxygen	140-146	MAS related GPR family member F	Homo sapiens	58-61
2659586-6	1989	When the myoglobin cDNA was expressed in Saccharomyces cerevisiae under the control of the GAL7 promoter, myoglobin was synthesized as a functionally active holoprotein which bound molecular oxygen reversibly.	Oxygen	191-197	UDP-glucose:hexose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	91-95
2536403-2	1989	In vitro, very low (pM and nM) concentrations of PAF "primed" rat neutrophils for enhanced O2-.	Oxygen	91-93	PCNA clamp associated factor	Rattus norvegicus	49-52
2536403-4	1989	The PAF receptor antagonist, L-652,731, blocked responses (O2-.	Oxygen	59-61	PCNA clamp associated factor	Rattus norvegicus	4-7
2627576-4	1989	Under in vivo conditions of oxygen tension, reaction rates were oxyhemoglobin greater than deoxyhemoglobin greater than methemoglobin.	Oxygen	28-34	hemoglobin subunit gamma 2	Homo sapiens	120-133
3182197-9	1988	The oxygen-treated rats showed positive GFAP-staining in astrocytes at all times and in Muller cells from 2 weeks post-treatment through 8 weeks post-treatment, the last time point.	Oxygen	4-10	glial fibrillary acidic protein	Rattus norvegicus	40-44
20177947-3	2011	The redox-sensing cysteine residues and the disulfide bond formed between these cysteine residues serve as redox-sensing molecular switches; these switches sense cellular oxidizing factors such as oxygen, reactive oxygen species, and cellular reducing factors such as thioredoxin (Trx), glutathione (GSH), and their family molecules.	Oxygen	197-203	thioredoxin	Homo sapiens	281-284
3182197-11	1988	These results indicate that Muller cells produce GFAP in response to oxygen-rearing in newborn rats and that this production occurs in the absence of any detectable neuronal cell death.	Oxygen	69-75	glial fibrillary acidic protein	Rattus norvegicus	49-53
2540640-3	1989	The relative amounts of the two metabolites varied with the stimulus and its concentration, TNF alpha and TNF beta favoring H2O2 production, C5a eliciting more O2- than H2O2 and the other active stimulants being in between.	Oxygen	126-128	lymphotoxin alpha	Homo sapiens	106-114
21320589-4	2011	We examined the properties of the alpha-Syn-Cu(II) complex with regard to molecular oxygen, the biological reducing agent ascorbate, and the neurotransmitter dopamine.	Oxygen	84-90	synuclein alpha	Homo sapiens	34-43
2559883-3	1989	Nitrosylhemoglobin shows a characteristic electron spin resonance (ESR) signal due to an odd electron localized on the nitrogen atom of NO and reacts with oxygen to yield nitrate and methemoglobin, which is rapidly reduced by methemoglobin reductase in red cells.	Oxygen	155-161	hemoglobin subunit gamma 2	Homo sapiens	183-196
2559883-3	1989	Nitrosylhemoglobin shows a characteristic electron spin resonance (ESR) signal due to an odd electron localized on the nitrogen atom of NO and reacts with oxygen to yield nitrate and methemoglobin, which is rapidly reduced by methemoglobin reductase in red cells.	Oxygen	155-161	hemoglobin subunit gamma 2	Homo sapiens	226-239
2972675-1	1988	To test the hypothesis that atrial natriuretic peptide (ANP) has a direct vasodilator effect on the pulmonary vasculature that is enhanced in hypoxia-induced pulmonary hypertension in the rat, we determined the effects of ANP on mean pulmonary (MPAP) and systemic arterial pressure (MSAP) in intact conscious Sprague-Dawley rats exposed to 10% O2 or room air for 4 wk.	Oxygen	344-346	natriuretic peptide A	Rattus norvegicus	28-54
21320589-8	2011	We demonstrate that the Cu(II) reduction by thiolate ligands of Zn7MT-3 and the formation of Cu(I)4Zn4MT-3, in which an unusual oxygen-stable Cu(I)4-thiolate cluster is present, comprise the underlying molecular mechanism by which alpha-Syn and dopamine oxidation, alpha-Syn oligomerization, and ROS production are abolished.	Oxygen	128-134	synuclein alpha	Homo sapiens	231-240
3170434-8	1988	In the process, cytochrome b reduction levels increase, possibly signaling an increased efficiency of oxidative phosphorylation relative to O2 uptake by unblocked respiratory chains.	Oxygen	140-142	cytochrome b, mitochondrial	Rattus norvegicus	16-28
21320589-8	2011	We demonstrate that the Cu(II) reduction by thiolate ligands of Zn7MT-3 and the formation of Cu(I)4Zn4MT-3, in which an unusual oxygen-stable Cu(I)4-thiolate cluster is present, comprise the underlying molecular mechanism by which alpha-Syn and dopamine oxidation, alpha-Syn oligomerization, and ROS production are abolished.	Oxygen	128-134	synuclein alpha	Homo sapiens	265-274
2539694-2	1989	Activation of neutrophils in vitro with interferon-gamma resulted in enhanced production of O2- and myelopeoroxidase-H2O2-halide activity by neutrophils in the presence of B. abortus.	Oxygen	92-94	interferon gamma	Bos taurus	40-56
21463685-4	2011	Under hypoxic conditions, multipotent RPCs upregulate Epo receptors, and Epo, along with insulin, protects against both superoxide- and severe hypoxia- (0.25% O2) induced apoptosis through activation of the canonical PI3K/Akt/mTOR pathway.	Oxygen	159-161	erythropoietin	Rattus norvegicus	73-76
2718544-1	1989	The purpose of the study was to explore the preserved (7-21 days) donor blood and erythrocytic mass, following perfusion through hemosorbent SKN-D. After the sorption the oxygen-transport function of erythrocytes was found to improve considerably (oxyhemoglobin dissociation curve was shifted to the right on average by 4-4.2 mm Hg).	Oxygen	171-177	hedgehog acyltransferase	Homo sapiens	141-144
2850768-11	1988	Under aerobic conditions the ferredoxin reductase/NADPH/actinomycin D system generated the superoxide anion radical by reducing molecular oxygen.	Oxygen	138-144	ferredoxin reductase	Bos taurus	29-49
16594007-1	1988	Although cytochrome b-559 has long been known as a membrane-bound redox component closely linked to the reaction center of the oxygen-generating photosystem (PSII), its role in photosynthesis has remained obscure.	Oxygen	127-133	mitochondrially encoded cytochrome b	Homo sapiens	9-21
3075657-3	1988	Expression of the whi2 phenotype only occurred above 40% oxygen saturation with either glucose or ethanol as carbon and energy source.	Oxygen	57-63	Whi2p	Saccharomyces cerevisiae S288C	18-22
3075657-5	1988	The results clearly show that the WHI2 gene of S. cerevisiae plays an important role in cell proliferation and that the availability of oxygen, or some product of oxidative metabolism, is involved in regulating the phenotypic expression of mutations within this gene.	Oxygen	136-142	Whi2p	Saccharomyces cerevisiae S288C	34-38
3415646-2	1988	The decreased rates of hydroxyl-radical generation at lower O2 concentrations correlates with lower rates of production of H2O2, the precursor of hydroxyl radical, whereas the decreased rates at elevated O2 concentrations correlate with lower rates (relative to 20% O2) of activity of NADPH-cytochrome P-450 reductase, which reduces iron and is responsible for redox cycling of iron by the microsomes.	Oxygen	60-62	cytochrome p450 oxidoreductase	Rattus norvegicus	285-317
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Oxygen	110-116	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	64-71
2836442-7	1988	The final xanthine oxidase step in purine catabolism generates reactive oxygen metabolites.	Oxygen	72-78	xanthine dehydrogenase	Mus musculus	10-26
3141421-2	1988	Mouse epidermal cells JB6 (clone 41) were exposed to active oxygen generated extracellularly by glucose/glucose oxidase (producing H2O2) or xanthine oxidase (producing H2O2 plus superoxide) or active oxygen produced intracellularly by the metabolism of menadione (producing mostly superoxide).	Oxygen	60-66	xanthine dehydrogenase	Mus musculus	140-156
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Oxygen	110-116	cytokine like 1	Homo sapiens	221-225
3378529-1	1988	Oxygen consumption at different stages of vigilance, and for the whole 24 h, was measured in 13 small-for-gestational age (SGA) and 16 appropriate-for-age (AGA) premature infants at ages of 4-25 days.	Oxygen	0-6	aspartylglucosaminidase	Homo sapiens	156-159
21446712-6	2011	Molecular dynamics simulations indicate that binding of the steroid nucleus perpendicular to the plane of the CYP21A2 heme ring limits access of the heme oxygen to the C-21 hydrogen atoms.	Oxygen	154-160	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	110-117
2838478-0	1988	Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase.	Oxygen	39-45	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	59-64
2838478-0	1988	Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase.	Oxygen	39-45	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	81-107
21512126-2	2011	HIF is a basic helix-loop-helix (bHLH)-PAS (PER-ARNT-SIM) heterodimer composed of an oxygen-labile HIF-alpha subunit and a constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) subunit, which dimerize via basic helix-loop-helix and PAS domains, and recruit coactivators via HIF-alpha C-terminal transactivation domains.	Oxygen	85-91	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	48-52
3382287-8	1988	In vitro studies revealed that human immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a in a dose-dependent manner, although human albumin treated identically as human immunoglobulin did not produce these complements.	Oxygen	75-81	complement C3	Homo sapiens	105-108
2826473-0	1988	The transition metal-mediated formation of the hydroxyl free radical during the reduction of molecular oxygen by ferredoxin-ferredoxin:NADP+ oxidoreductase.	Oxygen	103-109	thioredoxin reductase 1	Homo sapiens	141-155
2826473-1	1988	The NADPH-supported enzymatic reduction of molecular oxygen by ferredoxin-ferredoxin:NADP+ oxidoreductase was investigated.	Oxygen	53-59	thioredoxin reductase 1	Homo sapiens	91-105
2826473-12	1988	Ferredoxin:NADP+ oxidoreductase reduces ferredoxin, which in turn is responsible for the reduction of oxygen to hydrogen peroxide and ultimately the hydroxyl radical.	Oxygen	102-108	thioredoxin reductase 1	Homo sapiens	17-31
21169273-10	2011	Simulated ischaemia (60 min oxygen/glucose deprivation) caused a reduction at 24 h in both THY-1 mRNA and the numbers of NeuN-labelled neurons of HORCs.	Oxygen	28-34	Thy-1 cell surface antigen	Homo sapiens	91-96
2828111-2	1988	Similarly, the O2 tension at which cytochrome b was oxidized to 50% of its aerobic steady-state level in activated cells was 4.7 microM (+/- 1.0, n = 3): in non-activated cells the corresponding value for cytochrome b oxidation was 11.4 microM (+/- 2.8, n = 3).	Oxygen	15-17	cytochrome b, mitochondrial	Rattus norvegicus	35-47
2828111-2	1988	Similarly, the O2 tension at which cytochrome b was oxidized to 50% of its aerobic steady-state level in activated cells was 4.7 microM (+/- 1.0, n = 3): in non-activated cells the corresponding value for cytochrome b oxidation was 11.4 microM (+/- 2.8, n = 3).	Oxygen	15-17	cytochrome b, mitochondrial	Rattus norvegicus	205-217
3195138-2	1988	OHb exhibited high affinity to oxygen (P50 = 17 torr) as well as a decreased rate of the subunits cooperative interaction (n = 1.5-1.6); OHb-PLP possessed P50 = 27 torr, n = 2.2 (for pO2 greater than P50), Bore effect -0.4.	Oxygen	31-37	proteolipid protein 1	Homo sapiens	141-144
3381902-2	1988	O2 saturation of myoglobin (Mb) was determined from spectrophotometric measurements along individual fibers.	Oxygen	0-2	myoglobin	Canis lupus familiaris	17-26
2854415-7	1988	The second, slower phase is rate-limited at a first-order value of 500 sec-1 at or above 200 microM O2.	Oxygen	100-102	secretory blood group 1, pseudogene	Homo sapiens	71-76
23554691-8	2011	We demonstrate here that HRE and the recombinant Tet-On advanced double gene-controlled systems sensitively regulate the expression of hVEGF165 and Ang-1 genes in an altered oxygen environment and under pharmacological induction in vitro.	Oxygen	174-180	angiopoietin 1	Rattus norvegicus	148-153
2854415-8	1988	In contrast, the initial phase is proportional to O2 up to the highest O2 concentration used here (i.e. 340 microM) and reaches a rate of 6500 sec-1.	Oxygen	50-52	secretory blood group 1, pseudogene	Homo sapiens	143-148
2854415-8	1988	In contrast, the initial phase is proportional to O2 up to the highest O2 concentration used here (i.e. 340 microM) and reaches a rate of 6500 sec-1.	Oxygen	71-73	secretory blood group 1, pseudogene	Homo sapiens	143-148
2837203-4	1988	The present study provides the first evidence for the NADPH-cytochrome P-450 reductase catalyzed oxidation of hydrazine to its radical in the presence of O2 and NADPH.	Oxygen	154-156	cytochrome p450 oxidoreductase	Rattus norvegicus	54-86
21874857-4	2011	In LHR subjects, in the first 5-10 min of the hypoxia, a significantly lower level of the blood oxygen saturation was observed in comparison to the HHR.	Oxygen	96-102	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	3-6
2900738-8	1988	The fact that the reconstituted system, which contains NADPH-cytochrome P-450 reductase, is oxygen insensitive suggests that there is an obligatory electron flow through cytochrome P-450 to DAB, bypassing the oxygen-sensitive step.	Oxygen	92-98	cytochrome p450 oxidoreductase	Rattus norvegicus	55-87
2829973-0	1988	S-thiolation of creatine kinase and glycogen phosphorylase b initiated by partially reduced oxygen species.	Oxygen	92-98	glycogen phosphorylase B	Homo sapiens	36-60
2829973-1	1988	S-thiolation of cardiac creatine kinase and skeletal muscle glycogen phosphorylase b was initiated by reduced oxygen species in reaction mixtures containing reduced glutathione.	Oxygen	110-116	glycogen phosphorylase B	Homo sapiens	60-84
2902554-6	1988	GRP and CGRP levels decreased less among monkey infants ventilated with oxygen, thus they were significantly higher at 24 hours than in air ventilated controls.	Oxygen	72-78	gastrin releasing peptide	Homo sapiens	0-3
3332105-8	1987	Components related to the respiratory burst oxidase include cytochrome b558 (one of those subunits has recently been shown to be encoded by a gene that is defective in the most common form of CGD), a flavoprotein that participates directly in O2- production, a cytosolic factor needed for the activation of the oxidase, and a group of 48K phosphoproteins.	Oxygen	243-245	mitochondrially encoded cytochrome b	Homo sapiens	60-72
3120642-0	1987	Photoreduction of QA, QB, and cytochrome b-559 in an oxygen-evolving photosystem II preparation from the thermophilic cyanobacterium Synechococcus sp.	Oxygen	53-59	mitochondrially encoded cytochrome b	Homo sapiens	30-42
3179462-2	1988	Pyridoxylated hemoglobin (PLP-Hb), a possible substitute for red cells as an artificial oxygen carrier was prepared from outdated human blood.	Oxygen	88-94	proteolipid protein 1	Homo sapiens	26-29
21874857-9	2011	Possible role of the stress in the collapse-like reaction during acute hypoxia is analysed, which might cause increase of the oxygen request of the brain, higher growth of cerebral blood flow and more pronounced lowering of functional activity of the brain in the LHR subjects.	Oxygen	126-132	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	264-267
21212189-1	2011	PURPOSE: HIF1A is one of the major transcription factors that regulate tissue response to low oxygen tension.	Oxygen	94-100	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-14
3148460-3	1988	Compared to a control group, secretin caused a significant increase in pO2 and in O2 saturation (p less than 0.05).	Oxygen	72-74	secretin	Homo sapiens	29-37
3654799-6	1987	The value of local cerebral oxygen consumption obtained by this method was 3.02 +/- 0.61 mL O2/100 g brain/min; it was not influenced by the change in systemic blood pressure.	Oxygen	28-34	immunoglobulin kappa variable 1D-39	Homo sapiens	92-98
3654799-8	1987	At the stage of burst and suppression on electrocorticogram, cerebral oxygen consumption decreased significantly (p less than 0.001) to 1.03 +/- 0.07 mL O2/100 g brain/min.	Oxygen	70-76	immunoglobulin kappa variable 1D-39	Homo sapiens	153-159
21456637-2	2011	X-ray structural analysis shows that the 1-propanol oxygen atom is at a distance of 2.749 and 2.788 A from the closest clathrate hydrate water oxygen atoms from a hexagonal face of the large sII cage.	Oxygen	52-58	transcription elongation factor A1	Homo sapiens	191-194
3696161-4	1987	Since previous studies demonstrated an increase in steady state glyceraldehyde-3-phosphate dehydrogenase RNA during low O2 exposure it is concluded that the level of this RNA is regulated post transcriptionally whereas the other four glycolytic enzyme RNAs are regulated at least partially at the level of transcription by oxygen availability.	Oxygen	120-122	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	64-104
3696161-4	1987	Since previous studies demonstrated an increase in steady state glyceraldehyde-3-phosphate dehydrogenase RNA during low O2 exposure it is concluded that the level of this RNA is regulated post transcriptionally whereas the other four glycolytic enzyme RNAs are regulated at least partially at the level of transcription by oxygen availability.	Oxygen	323-329	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	64-104
2448772-4	1988	The distortion of the helix exposes the carbonyl oxygens of Aib1 and Aib4 to the outside environment, with the consequence that the helix assumes an amphiphilic character despite having all apolar residues.	Oxygen	49-56	ANIB1	Homo sapiens	60-64
21456637-2	2011	X-ray structural analysis shows that the 1-propanol oxygen atom is at a distance of 2.749 and 2.788 A from the closest clathrate hydrate water oxygen atoms from a hexagonal face of the large sII cage.	Oxygen	143-149	transcription elongation factor A1	Homo sapiens	191-194
3624223-3	1987	The reduction of a methemoglobin-oxyhemoglobin mixture with an imposed potential causes the electrochemical reduction of oxygen, the conversion of oxyhemoglobin into deoxyhemoglobin, and a simultaneous transformation of part of the molecules into methemoglobin.	Oxygen	121-127	hemoglobin subunit gamma 2	Homo sapiens	19-32
3624223-3	1987	The reduction of a methemoglobin-oxyhemoglobin mixture with an imposed potential causes the electrochemical reduction of oxygen, the conversion of oxyhemoglobin into deoxyhemoglobin, and a simultaneous transformation of part of the molecules into methemoglobin.	Oxygen	121-127	hemoglobin subunit gamma 2	Homo sapiens	247-260
3043460-1	1988	The occurrence of an oxo-bridged binuclear iron site is well-established for the oxygen transport protein, hemerythrin, and strongly implicated in ribonucleotide reductase, purple acid phosphatase, ferritin, and methane monooxygenase.	Oxygen	81-87	acid phosphatase 5, tartrate resistant	Homo sapiens	173-196
21263150-7	2011	Our studies indicate that pathways normally activated under hypoxia might be used by STAT5 under higher oxygen conditions to maintain and/or impose HSC self-renewal properties.	Oxygen	104-110	signal transducer and activator of transcription 5A	Homo sapiens	85-90
3425345-6	1987	Furthermore, the ventilatory equivalent for O2 at a given work load was markedly higher in the LPP than in the control condition, while exercise-induced decreases in end-tidal PCO2 were considerably exaggerated by LPP.	Oxygen	44-46	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	95-98
3624223-4	1987	When fixed oxygen has disappeared, reduction of methemoglobin takes place.	Oxygen	11-17	hemoglobin subunit gamma 2	Homo sapiens	48-61
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	99-105	glutamate-ammonia ligase	Rattus norvegicus	217-237
21256215-10	2011	Both CD47 and TSP1 null mice are leaner than WTs, use less oxygen and produce less heat than WT mice.	Oxygen	59-65	tumor suppressor region 1	Mus musculus	14-18
2954847-4	1987	The inhibition of oxygen consumption by NAD- and FAD-linked substrates was 40% for state 4 and 70% for ADP- or FCCP-stimulated respiration.	Oxygen	18-24	MAM domain containing glycosylphosphatidylinositol anchor 2	Mus musculus	103-107
3427034-9	1987	As a result, we infer that an interresidue hydrogen bond is formed, and we find it to be between the GlcNAc(beta 1,2) ring oxygen and the Man C3 hydroxyl.	Oxygen	123-129	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	108-116
3040748-8	1987	Increased oxygen tension during the PMA experiments increased the spin adduct lifetime.	Oxygen	10-16	spindlin 1	Homo sapiens	66-70
3578546-2	1987	State 3 respiratory rates and initial rates of inner membrane potential development dropped off in close parallel with one another as well as with NADH-coenzyme Q (CoQ) reductase activity, suggesting that oxygen uptake as well as membrane potential development were rate limited by the increasing impairment of electron flow through complex I.	Oxygen	205-211	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	147-178
3585543-2	1987	The cytochrome P-450 enzyme system can generate active oxygens by uncoupling of the P-450-oxy complex in the catalytic cycle and/or the electron transfer mediated by the NADPH-cytochrome P-450 reductase.	Oxygen	55-62	cytochrome p450 oxidoreductase	Rattus norvegicus	170-202
3493961-4	1987	Uptake and clearance of C-11 palmitate are proportional to cardiac work and oxygen consumption.	Oxygen	76-82	RNA polymerase III subunit K	Homo sapiens	24-28
19729212-0	2011	Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term.	Oxygen	71-77	prostaglandin E receptor 4	Homo sapiens	29-32
2433297-4	1987	Rats exposed to 5% O2 and probenecid for 0.5 h showed a statistically higher CSF lactate at 0.5 and 1.5 h reoxygenation (169 and 168% control, respectively).	Oxygen	19-21	colony stimulating factor 2	Rattus norvegicus	77-80
3498025-2	1987	Stimulation of the cells by zymosan showed that the potency of producing luminol-dependent chemiluminescence had been markedly increased in the CSF-treated cells, indicating increased generation of active oxygen species in these cells.	Oxygen	205-211	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	144-147
19764912-0	2011	Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy.	Oxygen	59-65	ephrin B2	Mus musculus	30-38
3530073-8	1986	The reduction in EMG activity observed with nasal CPAP was closely related to the improvement in hemoglobin oxygen saturation.	Oxygen	108-114	centromere protein J	Homo sapiens	50-54
3030169-6	1987	Lavage ECP levels correlated strongly with the severity of lung damage defined by pulmonary oxygenation index (PaO2/inspired fraction of O2).	Oxygen	113-115	ribonuclease A family member 3	Homo sapiens	7-10
21281817-6	2011	These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC.	Oxygen	42-48	proline rich mitotic checkpoint control factor	Homo sapiens	151-155
21053058-3	2011	Increased expression of the hypoxia-inducible factor-1alpha-subunit (HIF-1alpha) is also associated with tumour progression and is also known to induce HGF-signaling via up-regulation of the HGF-receptor Met, namely under canonical stress conditions like lack of oxygen.	Oxygen	263-269	hypoxia inducible factor 1, alpha subunit	Mus musculus	28-67
3820219-6	1987	The affinity (Kis) of eight substituted inhibitors for DBH was shown to correlate (r = 0.75) with the affinity (KD) of comparably substituted tyramines for the ternary DBH-oxygen-tyramine complex.	Oxygen	172-178	U2AF homology motif kinase 1	Rattus norvegicus	14-17
3028858-1	1987	A Ginkgo biloba extract (Gbe) containing flavonoids, among other compounds, was tested for the release of activated oxygen species (O-2, H2O2, OH.)	Oxygen	116-122	immunoglobulin kappa variable 1D-39	Homo sapiens	132-135
3028858-3	1987	The extract slows down O2 consumption (respiratory burst) of stimulated cells by its inhibitory action on NADPH-oxidase, the enzyme responsible for the reduction of O2 to O-2.	Oxygen	23-25	immunoglobulin kappa variable 1D-39	Homo sapiens	171-174
3028858-3	1987	The extract slows down O2 consumption (respiratory burst) of stimulated cells by its inhibitory action on NADPH-oxidase, the enzyme responsible for the reduction of O2 to O-2.	Oxygen	165-167	immunoglobulin kappa variable 1D-39	Homo sapiens	171-174
3096849-2	1986	It has been proposed that this enzyme may have a protective effect against cancer, as the two-electron reduction prevents the formation of toxic oxygen metabolites that may be generated as a result of the one-electron reduction catalysed by enzymes such as NADPH-cytochrome P-450 reductase.	Oxygen	145-151	cytochrome p450 oxidoreductase	Rattus norvegicus	257-289
3745049-5	1986	The results indicate that O2 diffusing through the wall of the large retinal arterioles represents the most important component of periarteriolar PO2.	Oxygen	26-28	PO2	Sus scrofa	146-149
21053058-3	2011	Increased expression of the hypoxia-inducible factor-1alpha-subunit (HIF-1alpha) is also associated with tumour progression and is also known to induce HGF-signaling via up-regulation of the HGF-receptor Met, namely under canonical stress conditions like lack of oxygen.	Oxygen	263-269	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-79
3722249-1	1986	Transcutaneous oxygen tension (TsPO2) was measured in the foot and chest of 39 patients with severe peripheral vascular disease and the Regional Perfusion Index (RPI) calculated (RPI = Foot TcPO2 divided by Chest TcPO2).	Oxygen	15-21	translocator protein 2	Homo sapiens	31-36
21053058-3	2011	Increased expression of the hypoxia-inducible factor-1alpha-subunit (HIF-1alpha) is also associated with tumour progression and is also known to induce HGF-signaling via up-regulation of the HGF-receptor Met, namely under canonical stress conditions like lack of oxygen.	Oxygen	263-269	met proto-oncogene	Mus musculus	191-203
21182588-0	2011	On the reaction of D-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity.	Oxygen	45-53	D-amino acid oxidase	Homo sapiens	19-39
3709542-6	1986	The results are interpreted in terms of increased electron density on O-3 when axially located in a P(5-coord) trigonal bipyramidal compound, thereby introducing enhanced electrostatic repulsions within the oxygen pairs O-3, O-2 and O-3, O-1.	Oxygen	207-213	immunoglobulin kappa variable 1D-39	Homo sapiens	225-241
3814176-7	1987	When [18O]H2O was included in incubations of microsomes and CS2, a substantial portion of the resulting COS was [18O] enriched, indicating that the oxygen atom was derived from water.	Oxygen	148-154	calsyntenin 2	Rattus norvegicus	60-63
2439223-10	1987	VP-16 toxicity was ameliorated by anoxic conditions (less than 1% O2), but not by oxygen concentrations of 2.5%-95%.	Oxygen	66-68	host cell factor C1	Homo sapiens	0-5
21182588-0	2011	On the reaction of D-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity.	Oxygen	55-57	D-amino acid oxidase	Homo sapiens	19-39
21182588-2	2011	We also have recently described channels that might allow access of oxygen to pockets at the active site of the flavoprotein D-amino acid oxidase (DAAO) that have a high affinity for dioxygen and are in close proximity to the flavin.	Oxygen	68-74	D-amino acid oxidase	Homo sapiens	125-145
3018363-1	1986	The cytotoxic metabolites of oxygen [superoxide (O-2), hydrogen peroxide (H2O2), and hydroxyl (OH.)]	Oxygen	29-35	immunoglobulin kappa variable 1D-39	Homo sapiens	49-52
21182588-2	2011	We also have recently described channels that might allow access of oxygen to pockets at the active site of the flavoprotein D-amino acid oxidase (DAAO) that have a high affinity for dioxygen and are in close proximity to the flavin.	Oxygen	68-74	D-amino acid oxidase	Homo sapiens	147-151
21182588-2	2011	We also have recently described channels that might allow access of oxygen to pockets at the active site of the flavoprotein D-amino acid oxidase (DAAO) that have a high affinity for dioxygen and are in close proximity to the flavin.	Oxygen	183-191	D-amino acid oxidase	Homo sapiens	125-145
3700413-1	1986	Evidence of a requirement for C-3 oxygen in C-19 hydroxylations.	Oxygen	34-40	complement C3	Homo sapiens	30-33
3700413-2	1986	Substitution of a methylene group for the C-3 oxygen in androstenedione, testosterone, and the corresponding 19-hydroxy and 19-oxo derivatives results in a new category of inhibitors of estrogen biosynthesis by human placental microsomes.	Oxygen	46-52	complement C3	Homo sapiens	42-45
3700413-6	1986	Time-dependent inhibition of aromatization by 10 beta-difluoromethylestr-4-ene-3,17-dione and 10 beta-(2-propynyl)estr-4-ene,3,17-dione was abolished by substitution of a methylene function for the C-3 oxygen, suggesting that the presence of an oxygen at C-3 is required for an oxidative transformation at C-19, an initial step in aromatization.	Oxygen	202-208	complement C3	Homo sapiens	198-201
3700413-6	1986	Time-dependent inhibition of aromatization by 10 beta-difluoromethylestr-4-ene-3,17-dione and 10 beta-(2-propynyl)estr-4-ene,3,17-dione was abolished by substitution of a methylene function for the C-3 oxygen, suggesting that the presence of an oxygen at C-3 is required for an oxidative transformation at C-19, an initial step in aromatization.	Oxygen	202-208	complement C3	Homo sapiens	255-258
3700413-6	1986	Time-dependent inhibition of aromatization by 10 beta-difluoromethylestr-4-ene-3,17-dione and 10 beta-(2-propynyl)estr-4-ene,3,17-dione was abolished by substitution of a methylene function for the C-3 oxygen, suggesting that the presence of an oxygen at C-3 is required for an oxidative transformation at C-19, an initial step in aromatization.	Oxygen	245-251	complement C3	Homo sapiens	198-201
3700413-6	1986	Time-dependent inhibition of aromatization by 10 beta-difluoromethylestr-4-ene-3,17-dione and 10 beta-(2-propynyl)estr-4-ene,3,17-dione was abolished by substitution of a methylene function for the C-3 oxygen, suggesting that the presence of an oxygen at C-3 is required for an oxidative transformation at C-19, an initial step in aromatization.	Oxygen	245-251	complement C3	Homo sapiens	255-258
2881666-2	1987	Oxygen consumption [mm3 (STP)/mg (dry wt)/hr] was found to be linearly related to load (r = 0.98), increasing from 1.57 +/- 0.11 (SE) at 2 g to 2.30 +/- 0.18 at 10 g, 2.89 +/- 0.16 at 20 g and 3.26 +/- 0.21 at 30 g. Lactate released into the medium [microM/g (dry wt)/hr] was inversely related to load (r = -0.52), increasing initially from 36.84 +/- 3.28 (SE) at 2 g to 108.55 +/- 12.9 at 10 g, then abruptly decreasing with additional loading (18.10 +/- 2.60 at 20 g and 11.71 +/- 2.80 at 30 g).	Oxygen	0-6	thyroid hormone receptor interactor 10	Homo sapiens	25-28
2462531-1	1987	When NADPH-cytochrome P-450 reductase isolated from rat liver microsomes was aerobically incubated with bleomycin, FeCl3, NADPH and DNA parallel NADPH and oxygen were consumed and malondialdehyde was formed.	Oxygen	155-161	cytochrome p450 oxidoreductase	Rattus norvegicus	5-37
3546084-7	1987	When accumulated, paraquat undergoes a NADPH-dependent one-electron reduction to for its free radical which almost instantly reacts with molecular oxygen to reform the cation and concomitantly produce superoxide anion.	Oxygen	147-153	2,4-dienoyl-CoA reductase 1	Homo sapiens	39-44
21182588-2	2011	We also have recently described channels that might allow access of oxygen to pockets at the active site of the flavoprotein D-amino acid oxidase (DAAO) that have a high affinity for dioxygen and are in close proximity to the flavin.	Oxygen	183-191	D-amino acid oxidase	Homo sapiens	147-151
3963215-6	1986	Oxygen consumption in the LAD perfusion field was unchanged by hypoxia before ADA but fell significantly during hypoxia after ADA.	Oxygen	0-6	adenosine deaminase	Canis lupus familiaris	78-81
21182588-3	2011	With the goal of enhancing the reactivity of DAAO with oxygen, we have performed site-saturation mutagenesis at three positions that flank the putative oxygen channels and high-affinity sites.	Oxygen	55-61	D-amino acid oxidase	Homo sapiens	45-49
3963215-6	1986	Oxygen consumption in the LAD perfusion field was unchanged by hypoxia before ADA but fell significantly during hypoxia after ADA.	Oxygen	0-6	adenosine deaminase	Canis lupus familiaris	126-129
3499487-4	1987	We found that temporal lobe oxygen utilisation in the irradiated group (mean 2.11 +/- 0.23 ml of O2/100 ml tissue/min) did not differ from the normal group (mean 2.13 +/- 0.26 ml of O2/100 ml tissue/min).	Oxygen	28-34	immunoglobulin kappa variable 1D-39	Homo sapiens	97-103
21182588-5	2011	The biochemical properties of these variants have been studied and compared with those of wild-type DAAO, with emphasis on the reactivity of the reduced enzyme species with dioxygen.	Oxygen	173-181	D-amino acid oxidase	Homo sapiens	100-104
21182588-9	2011	The increase in O(2) reactivity observed for T201L DAAO is of great interest for designing new flavoenzymes for biotechnological applications.	Oxygen	16-20	D-amino acid oxidase	Homo sapiens	51-55
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Oxygen	132-138	complement C3	Homo sapiens	37-40
20980169-9	2011	Adjusted maximum oxygen consumption was higher for HTx patients (p = 0.05) relative to LVAD patients at 8 +- 1 months after implant.	Oxygen	17-23	Zic family member 3	Homo sapiens	51-54
3703591-9	1986	In patients who require only short-term supplemental O2, type 1 changes may reflect delayed resolution of RDS in an underdeveloped lung.	Oxygen	53-55	peripherin 2	Homo sapiens	106-109
3026385-0	1986	A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system.	Oxygen	13-19	linoleate 9S-lipoxygenase-4	Glycine max	50-62
3026385-1	1986	Studies of the oxygenation of linoleic acid by soybean lipoxygenase utilizing electron spin resonance spectroscopy and oxygen uptake have been undertaken.	Oxygen	15-21	linoleate 9S-lipoxygenase-4	Glycine max	55-67
21456242-2	2011	Bands at 1152 and 1322 cm(-1) were also similar to SERS of metal catecholates, and could be assigned to catechol ring vibration and carbon-oxygen stretches.	Oxygen	139-145	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	51-55
3021906-1	1986	Mouse cortical synaptosomal structure and function are altered when exposed to hypoxanthine/xanthine oxidase (HPX/XOD)-generated active oxygen/free radical species.	Oxygen	136-142	xanthine dehydrogenase	Mus musculus	92-108
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	47-54	complement C3	Homo sapiens	65-68
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	47-54	complement C9	Homo sapiens	75-78
21059898-0	2011	Granulocyte colony-stimulating factor attenuates oxidative stress-induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy.	Oxygen	175-181	colony stimulating factor 3	Homo sapiens	0-37
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	217-224	complement C3	Homo sapiens	65-68
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Oxygen	217-224	complement C9	Homo sapiens	75-78
3952263-8	1986	There was also a significant positive correlation between the glucose/oxygen quotient and the plasma concentration of insulin in the fetus (r = 0.73, n = 59, P less than 0.01).	Oxygen	70-76	LOC105613195	Ovis aries	118-125
2996616-4	1985	We exposed mouse fibroblasts to xanthine oxidase and acetaldehyde, a system which mimics the membrane of phagocytic cells in terms of production of oxygen species.	Oxygen	148-154	xanthine dehydrogenase	Mus musculus	32-48
3816735-14	1986	Oxidation of the Fe2+ in hemoglobin to Fe3+ forms methemoglobin, which is incapable of carrying either O2 or CO2.	Oxygen	103-105	hemoglobin subunit gamma 2	Homo sapiens	50-63
3790512-0	1986	Differential scanning calorimetric studies of photosystem II: evidence for a structural role for cytochrome b559 in the oxygen-evolving complex.	Oxygen	120-126	mitochondrially encoded cytochrome b	Homo sapiens	97-109
3766756-1	1986	The intracellular distribution of O2 in cross sections of dog gracilis muscles was determined by myoglobin (Mb) cryospectrophotometry.	Oxygen	34-36	myoglobin	Canis lupus familiaris	97-106
20947330-7	2011	The immobilized CYP1A1 displayed a pair of redox peaks with a formal potential of -0.36 mV in pH 7.0 O(2)-free phosphate buffers at scan rate of 1 V s(-1).	Oxygen	101-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-22
3019454-5	1986	Cytochrome b was not found in granulocytes or subcellular fractions despite the use of a spectrophotometric assay sensitive enough to detect the cytochrome if its content were proportional to the residual rate of O2- generation.	Oxygen	213-215	mitochondrially encoded cytochrome b	Homo sapiens	0-12
3017930-2	1986	Extracellular release of superoxide anion (O-2) and hydrogen peroxide (H2O2) during the respiratory burst of porcine and human neutrophils was studied by using diacetyldeuteroheme-substituted horseradish peroxidase as a trapping agent for these oxygen derivatives.	Oxygen	245-251	immunoglobulin kappa variable 1D-39	Homo sapiens	43-46
3017930-6	1986	These results establish that neutrophils stimulated with the phorbol ester produce exclusively O-2 as the primary oxygen metabolite and release it into the extracellular medium.	Oxygen	114-120	immunoglobulin kappa variable 1D-39	Homo sapiens	95-98
4090388-0	1985	[Effect of changes in the oxygen level on cholesterol esterase activity of the liver of intact rats and rats subjected to chronic hypoxia].	Oxygen	26-32	carboxyl ester lipase	Rattus norvegicus	42-62
20947330-8	2011	The CYP1A1 in the nano-SWy-2-DHP film retained its bioactivity and could catalyze the reduction of dissolved oxygen.	Oxygen	109-115	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	4-10
3898919-0	1985	Optimization of oxygenation by CPAP during one-lung anesthesia using nitrous oxide:oxygen.	Oxygen	16-22	centromere protein J	Homo sapiens	31-35
20947330-9	2011	Upon the addition of its substrate benzo[a]pyrene (B[a]P) to the air-saturated solution, the reduction peak current of dissolved oxygen increased, which indicates the catalytic behavior of CYP1A1 to B[a]P. By amperometry a calibration linear range for B[a]P was obtained to be 3.31-16.56 muM with a sensitivity of 58.57 muA mM(-1).	Oxygen	129-135	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	189-195
3092679-5	1986	As fetal plasma insulin concentration rose, the blood concentrations of oxygen, glucose, lactate, and amino-nitrogen fell, but the fetal uptakes of oxygen, glucose, and amino-nitrogen rose.	Oxygen	72-78	LOC105613195	Ovis aries	16-23
21239881-4	2011	We have recently shown that the oxygen dependent transcription factor hypoxia inducible factor 1alpha (Hif1alpha) is essential for maintenance of functional levels of telomerase in murine embryonic stem cells (mES).	Oxygen	32-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	70-101
3791352-1	1986	Myoglobin, an intracellular iron containing protein that binds oxygen reversibly, has been shown in model systems to facilitate the diffusion of oxygen and thereby maintain the mechanical function of exercising canine skeletal muscle and of hypoxic benthic fish hearts.	Oxygen	63-69	myoglobin	Canis lupus familiaris	0-9
3791352-1	1986	Myoglobin, an intracellular iron containing protein that binds oxygen reversibly, has been shown in model systems to facilitate the diffusion of oxygen and thereby maintain the mechanical function of exercising canine skeletal muscle and of hypoxic benthic fish hearts.	Oxygen	145-151	myoglobin	Canis lupus familiaris	0-9
3906268-2	1985	The subjects with electroencephalographic and sensory signs of stimulating reticular-hypothalamic-amygdalic effects balanced with inhibitory cortical-striatic-septic-hippocampal-epiphyseal effects showed a high oxygen consumption, moderate excretion of epinephrine and norepinephrine, moderate plasma concentrations of ACTH, cortisol, total and free 11-OHCS and insulin, relatively high concentrations of STH, as well as specific dynamics of hormonal and metabolic reactions to aerobic effects.	Oxygen	211-217	saitohin	Homo sapiens	405-408
4017990-2	1985	The amount of methemoglobin formed was determined by an anaerobic modification of the Evelyn-Malloy method; 59% of the total hemoglobin of whole blood was oxidized to methemoglobin in the first 15 min of the oxygen exposure and 78% of the total hemoglobin was oxidized after 120 min of oxygen exposure.	Oxygen	208-214	hemoglobin subunit gamma 2	Homo sapiens	14-27
3729018-1	1986	The free oxygen concentrations required for reductive defluorination of halothane by rat hepatic microsomes from control and phenobarbital- (PB) and polychlorinated biphenyl-(PCB) treated animals were determined.	Oxygen	9-15	pyruvate carboxylase	Rattus norvegicus	175-178
4017990-2	1985	The amount of methemoglobin formed was determined by an anaerobic modification of the Evelyn-Malloy method; 59% of the total hemoglobin of whole blood was oxidized to methemoglobin in the first 15 min of the oxygen exposure and 78% of the total hemoglobin was oxidized after 120 min of oxygen exposure.	Oxygen	208-214	hemoglobin subunit gamma 2	Homo sapiens	167-180
21239881-4	2011	We have recently shown that the oxygen dependent transcription factor hypoxia inducible factor 1alpha (Hif1alpha) is essential for maintenance of functional levels of telomerase in murine embryonic stem cells (mES).	Oxygen	32-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	103-112
4017990-2	1985	The amount of methemoglobin formed was determined by an anaerobic modification of the Evelyn-Malloy method; 59% of the total hemoglobin of whole blood was oxidized to methemoglobin in the first 15 min of the oxygen exposure and 78% of the total hemoglobin was oxidized after 120 min of oxygen exposure.	Oxygen	286-292	hemoglobin subunit gamma 2	Homo sapiens	14-27
20966168-12	2011	SIRT1(-/-) and SIRT1(+/-) adult marrow had decreased numbers and cycling of hematopoietic progenitors, effects more apparent at 5%, than at 20%, oxygen tension, and these progenitors survived less well in vitro under conditions of delayed growth factor addition.	Oxygen	145-151	sirtuin 1	Mus musculus	0-5
4022032-4	1985	The clastogenicity of fractions 1 and 2 (the two most hydrophilic) was abolished by the addition of either catalase or superoxide dismutase to the Chinese hamster ovary cell system, suggesting the involvement of active oxygen species in the clastogenic response.	Oxygen	219-225	catalase	Cricetulus griseus	107-115
3017331-1	1986	Ubiquinone and cytochrome b566 have both been postulated to cause mitochondrial O2 formation by autoxidation of their reduced forms.	Oxygen	80-82	mitochondrially encoded cytochrome b	Homo sapiens	15-27
3017331-7	1986	Our findings suggest a role of cytochrome b 566 in mitochondrial O2 formation.	Oxygen	65-67	mitochondrially encoded cytochrome b	Homo sapiens	31-43
3012624-0	1986	Radiation sensitization by oxygen of in vitro mammalian cells: is .O-2 involved?	Oxygen	27-33	immunoglobulin kappa variable 1D-39	Homo sapiens	67-70
3012624-1	1986	Oxygen is a potent sensitizer of cells exposed to ionizing radiation, and, although the exact chemical mechanisms are not fully understood, some evidence suggests that this sensitization may involve the formation of superoxide anion radicals (.O-2) [F. Lavelle, A. M. Michelson, and L. Dimitrijevic, Biochem.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	244-247
3012624-11	1986	In these tests, although oxygen was present, be blocked the radiation-induced reactions of O2 which produce .O-2.	Oxygen	25-31	immunoglobulin kappa variable 1D-39	Homo sapiens	109-112
3012624-11	1986	In these tests, although oxygen was present, be blocked the radiation-induced reactions of O2 which produce .O-2.	Oxygen	91-93	immunoglobulin kappa variable 1D-39	Homo sapiens	109-112
2988006-3	1985	The data obtained prompt an assumption that the increase in the rate of O2- generation is perhaps connected with the changes in functioning of both NADPH-cytochrome P-450-reductase and cytochrome P-450.	Oxygen	72-74	cytochrome p450 oxidoreductase	Rattus norvegicus	148-180
2982386-4	1985	The phenolate anion could be further oxidized by molecular oxygen to generate the C-6, C-11 (B-ring) semiquinone as detected by a weak electron paramagnetic resonance spectrometry signal.	Oxygen	59-65	RNA polymerase III subunit K	Homo sapiens	87-91
20966168-12	2011	SIRT1(-/-) and SIRT1(+/-) adult marrow had decreased numbers and cycling of hematopoietic progenitors, effects more apparent at 5%, than at 20%, oxygen tension, and these progenitors survived less well in vitro under conditions of delayed growth factor addition.	Oxygen	145-151	sirtuin 1	Mus musculus	15-20
3754200-3	1986	A clinical trial which looked at the outcome of premature infants with and without transcutaneous O2 monitoring would be useful not only to determine the impact on the prevalence of RLF, but also to determine the role of this technology in the management of premature infants generally.	Oxygen	98-100	RLF zinc finger	Homo sapiens	182-185
21249227-0	2011	14-3-3 sigma expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.	Oxygen	49-55	stratifin	Homo sapiens	0-12
3955031-3	1986	Each molecule is chelated through the C-12-carbonyl and the C-11-phenolate oxygen atoms.	Oxygen	75-81	RNA polymerase III subunit K	Homo sapiens	60-64
3933197-3	1985	With a secretin infusion alone (0 to 60 mins) there was a transient, significant rise in PO2 (p less than 0.01) and oxygen saturation (p less than 0.05), which was no longer detectable after 60 minutes (p greater than 0.05).	Oxygen	116-122	secretin	Homo sapiens	7-15
3933197-8	1985	The isolated increase in PO2 and O2 saturation may be attributed to vasodilation induced by secretin.	Oxygen	26-28	secretin	Homo sapiens	92-100
21249227-6	2011	Targeting 14-3-3 sigma overexpression with RNAi restored O2 sensitivity in these cell lines.	Oxygen	57-59	stratifin	Homo sapiens	10-22
2981535-1	1985	When perfused cortex-free ox adrenal medulla was stimulated to secrete catecholamine by infusion of 0.1 mM acetylcholine for 4 min, the oxygen consumption increased to a value which was 0.15 +/- 0.07 mumole O2/min/g wet weight (+/- S.D., N = 12) above the pre-stimulation value of 0.49 +/- 0.15 (P less than 0.001).	Oxygen	136-142	immunoglobulin kappa variable 1D-39	Homo sapiens	207-213
21209661-9	2011	As interactions between oxygen atoms at positions C1 and C2 (O1 and O2, respectively) on the pyranose ring can alter the exo/endo ratio of a carbohydrate, our results suggest that it will be important to re-evaluate the influence, and biological effects, of substituents at position C2 in sugars.	Oxygen	24-30	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-70
3965156-7	1985	Following N2 incubation at 37 degrees C for 1 h there was no evidence of metabolism, whereas there was more than 50% decrease in parent drug within 1 h following O2 incubation in the presence of NADPH generating system, suggesting that the metabolic process involves an oxidative reduction.	Oxygen	162-164	2,4-dienoyl-CoA reductase 1	Homo sapiens	195-200
3512538-0	1986	Negative control of yeast coproporphyrinogen oxidase synthesis by heme and oxygen.	Oxygen	75-81	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	26-52
3512538-7	1986	This demonstrates that coproporphyrinogen oxidase synthesis is regulated by heme and oxygen at a pretranslational level in a negative fashion.	Oxygen	85-91	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	23-49
21129412-3	2011	Significant nuclear levels of ARNT and HIF1alpha along with high HIF1 activity in normoxic keratinocytes suggest an as yet uncharacterised oxygen-independent role for HIF pathway in the epidermis.	Oxygen	139-145	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	30-34
3799329-3	1986	After the administration of CCK, blood flow as well as O2 consumption were increased, while O2 extraction initially remained unchanged but later it increased.	Oxygen	55-57	cholecystokinin	Canis lupus familiaris	28-31
3799329-3	1986	After the administration of CCK, blood flow as well as O2 consumption were increased, while O2 extraction initially remained unchanged but later it increased.	Oxygen	92-94	cholecystokinin	Canis lupus familiaris	28-31
3799329-6	1986	These simulations revealed that during the CCK stimulation of the pancreas is able to control its O2 supply through a fast decrease of the arteriolar resistance and a slow capillary recruitment.	Oxygen	98-100	cholecystokinin	Canis lupus familiaris	43-46
3974224-2	1985	The C-13 angular methyl group of prednisolone-17 alpha,21-acetonide-11 beta-nitrite was functionalized by photolysis in the presence of oxygen to give the product 18-hydroxy-prednisolone-17 alpha,21-acetonide-18-nitrate.	Oxygen	136-142	homeobox C13	Homo sapiens	4-8
21525597-5	2011	Using cytokine protein arrays and real time gene expression analysis, we indeed found that low oxygen exposure increased expression of characteristic macrophage inflammatory cytokines such as IL-1, IL-6, and TNF-alpha.	Oxygen	95-101	interleukin 1 alpha	Homo sapiens	192-196
6441898-0	1984	Blood flow compensates oxygen demand in the vulnerable CA3 region of the hippocampus during kainate-induced seizures.	Oxygen	23-29	carbonic anhydrase 3	Rattus norvegicus	55-58
3952387-4	1986	In each compartment O2 is removed by the tissues as a chemical reaction takes place between O2 and oxyhemoglobin (HbO2).	Oxygen	20-22	immunoglobulin kappa variable 1D-39	Homo sapiens	92-112
20886368-0	2011	The role of beta-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro.	Oxygen	103-109	catenin beta 1	Rattus norvegicus	12-24
4062295-4	1985	Reduction of methemoglobin is optimally observed under nitrogen since, in the presence of oxygen, reduced divicine undergoes autoxidation.	Oxygen	90-96	hemoglobin subunit gamma 2	Homo sapiens	13-26
6208195-3	1984	The monooxygenase is dependent upon NADPH plus oxygen, insensitive to CN-, and sensitive to CO. Microsomal oxidation is also sensitive to trypsin digestion, and reactivation is dependent upon the addition of purified, detergent-solubilized cytochrome P-450 reductase.	Oxygen	8-14	2,4-dienoyl-CoA reductase 1	Homo sapiens	36-41
21071060-6	2011	The C2 and C3 had a direct relationship with a(CDOM)(355), dissolved organic carbon (DOC), and chemical oxygen demand (COD).	Oxygen	104-110	complement C2	Homo sapiens	4-13
6435889-5	1984	It is concluded that acquired resistance to facultative intracellular pathogens--at least in part--depends on the activation of macrophage oxygen metabolism by IFN-gamma derived from specific Lyt 1+2,3- T cells.	Oxygen	139-145	CD8 antigen, beta chain 1	Mus musculus	192-201
2995796-1	1985	The relationship between the generation of active species of oxygen (O-2, H2O2 and OH.	Oxygen	61-67	immunoglobulin kappa variable 1D-39	Homo sapiens	69-72
2995796-5	1985	and/or 1O2 scavengers (benzoate, 1,4-diazo-bicyclo-2,2,2-octane or xanthine) caused a marked increase in enzyme release and a decrease in the generation of active-oxygen species except O-2 and H2O2.	Oxygen	163-169	immunoglobulin kappa variable 1D-39	Homo sapiens	185-188
2987348-4	1985	Translocation of cytochrome b-245 parallels O2-production initiated by PMA stimulation as assessed in the time course of each activity.	Oxygen	44-46	mitochondrially encoded cytochrome b	Homo sapiens	17-29
4003568-0	1985	Oxygen transport in rest-work transition illustrates new functions for myoglobin.	Oxygen	0-6	myoglobin	Canis lupus familiaris	71-80
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	35-39	linoleate 9S-lipoxygenase-4	Glycine max	94-106
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	35-39	linoleate 9S-lipoxygenase-4	Glycine max	201-213
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	142-146	linoleate 9S-lipoxygenase-4	Glycine max	94-106
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	142-146	linoleate 9S-lipoxygenase-4	Glycine max	201-213
21950764-3	2011	alpha-Hemoglobin stabilizing protein forms a heterodimer complex with alpha-Hb, then displaying modified oxygen binding kinetics.	Oxygen	105-111	alpha hemoglobin stabilizing protein	Homo sapiens	0-36
6083770-9	1984	These oxygen species function as oxidizing agents for AA metabolism and amplify the production of hydroxyl radical along the lipoxygenase (and possibly cyclooxygenase) pathway(s).	Oxygen	6-12	linoleate 9S-lipoxygenase-4	Glycine max	125-137
2990531-8	1985	The 53 ppm downfield shift upon the addition of substrate along with 1H NMR data suggests that one oxygen ligand to Cd2+ in the binary complex is replaced by a nitrogen ligand at some intermediate point in the enzymic reaction.	Oxygen	99-105	T-cell surface antigen CD2	Oryctolagus cuniculus	116-119
20373035-7	2011	These spots were identified as 16 different proteins by Matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and tandem TOF/TOF MS, and were potentially involved in protein degradation, defense signal transfer, reactive oxygen, cell wall reinforcement, and energy and metabolism regulation.	Oxygen	261-267	FEZ family zinc finger 2	Homo sapiens	161-164
3988729-17	1985	It is necessary for maintenance of the oxygen transport function of the red cell for reductants such as the methemoglobin reductase system, glutathione, and ascorbate to be able to reduce metHb to deoxy-Hb.	Oxygen	39-45	hemoglobin subunit gamma 2	Homo sapiens	108-121
24221235-7	1985	Elevated oxygen concentrations in samples incubated at 150muE  m(-2) sec(-1) decreased rates of both photosynthesis and net excretion.	Oxygen	9-15	secretory blood group 1, pseudogene	Homo sapiens	69-75
6744469-8	1984	With toxic concentrations of selenite (100 microM) it appeared that O2 reduction was eventually limited by the capacity of the cell to regenerate NADPH.	Oxygen	68-70	2,4-dienoyl-CoA reductase 1	Homo sapiens	146-151
6377900-0	1984	The effect of insulin on ovine fetal oxygen extraction.	Oxygen	37-43	LOC105613195	Ovis aries	14-21
6377900-7	1984	Oxygen consumption by the ovine fetus increased as insulin concentration rose.	Oxygen	0-6	LOC105613195	Ovis aries	51-58
20373035-7	2011	These spots were identified as 16 different proteins by Matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and tandem TOF/TOF MS, and were potentially involved in protein degradation, defense signal transfer, reactive oxygen, cell wall reinforcement, and energy and metabolism regulation.	Oxygen	261-267	FEZ family zinc finger 2	Homo sapiens	161-164
21060958-9	2011	Proof-of-principle results showing that cytochrome c peroxidase (CcP) for NO detection and myoglobin (Mb) for O2 detection can be successfully used by exploiting our new methodology are reported.	Oxygen	110-112	myoglobin	Homo sapiens	91-100
6725961-1	1984	The enzyme responsible for the respiratory burst in human neutrophils is an oxidase that catalyzes the reduction of oxygen to superoxide anion (O-2).	Oxygen	116-122	immunoglobulin kappa variable 1D-39	Homo sapiens	144-147
2983184-7	1985	Analogs that lack the C-11-hydroxyl group are relatively inefficient at oxygen reduction, hydroxyl radical formation, and DNA cleavage.	Oxygen	72-78	RNA polymerase III subunit K	Homo sapiens	22-26
2983185-5	1985	Calculated electron and spin densities indicate that the radical formed by H abstraction from the phenol oxygen does not remain localized on the oxygen, but is primarily a semiquinone aryl radical with significant unpaired spin density on the ring carbon atoms, particularly on C-3 and C-5.	Oxygen	105-111	complement C3	Homo sapiens	278-281
22043302-0	2011	N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.	Oxygen	69-75	neural cell adhesion molecule 1	Homo sapiens	0-5
3880742-4	1985	One important consequence of this deeper insertion of the pyrimidine into the active site of chicken dihydrofolate reductase is the loss of a potential hydrogen bond that would otherwise form between the carbonyl oxygen of Val-115 and the inhibitor"s 4-amino group.	Oxygen	213-219	dihydrofolate reductase	Gallus gallus	101-124
6394300-3	1984	Resuscitative efforts to reestablish and preserve an adequate circulating volume of oxygenated blood must follow, using airways, oxygen therapy, and fluid replacement through MAST trousers and intravenous fluids.	Oxygen	84-90	SPG21 abhydrolase domain containing, maspardin	Homo sapiens	175-179
6431500-1	1984	Sodium iothalamate produced a dose dependent increase in basal oxygen consumption when soybean lipoxygenase was incubated with arachidonic acid in 0.1M borate buffer pH 9.0.	Oxygen	63-69	linoleate 9S-lipoxygenase-4	Glycine max	95-107
22043302-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Notably, during oxygen induced retinopathy (OIR) N-CAM accumulated on astrocytes surrounding the epiretinal tufts.	Oxygen	48-54	neural cell adhesion molecule 1	Homo sapiens	81-86
3832865-0	1985	Oxygen permeability of methemoglobin solutions soaked in Millipore filters.	Oxygen	0-6	hemoglobin subunit gamma 2	Homo sapiens	23-36
22046389-11	2011	Aerosolized EC-SOD protected mice against oxygen toxicity and reduced mortality in a hyperoxic model.	Oxygen	42-48	superoxide dismutase 3, extracellular	Mus musculus	12-18
3897793-1	1985	As a first step in an analysis of the DNA regions involved in the control of the catalase A gene of Saccharomyces cerevisiae by glucose, heme, and oxygen this gene has been cloned.	Oxygen	147-153	catalase A	Saccharomyces cerevisiae S288C	81-91
6534110-0	1984	Oxygen affinity of hemoglobin solutions modified by coupling to PLP or NFPLP and the effects on tissue oxygenation.	Oxygen	0-6	proteolipid protein 1	Homo sapiens	64-67
6361193-4	1984	Insulin produced a 4.9-fold increase in glucose extraction and a 3.5-fold increase in glucose/oxygen quotient across the hindlimb; in contrast, insulin did not significantly affect uterine or fetal glucose extraction or glucose/oxygen quotient.	Oxygen	94-100	LOC105613195	Ovis aries	0-7
6666195-4	1983	Inborn enzyme deficiency of the oxygen metabolism such as NADPH oxidase or cytochrome b-245 deficiency lead to chronic septic granulomatosis.	Oxygen	32-38	mitochondrially encoded cytochrome b	Homo sapiens	75-87
2867640-0	1985	Effect of oxygen on the tetrazolium reaction for glucose 6-phosphate dehydrogenase in cryosections of human breast carcinoma, fibrocystic disease and normal breast tissue.	Oxygen	10-16	glucose-6-phosphate dehydrogenase	Homo sapiens	49-82
21811636-7	2011	Indeed, primary cardiomyocytes and HL-1 cardiac cells both induce Epo gene expression when exposed to low O(2) tension in a HIF-dependent manner.	Oxygen	106-110	erythropoietin	Mus musculus	66-69
6093764-2	1984	The superoxide anion is believed to be a cause of tissue damage in CNS oxygen toxicity and it is proposed that xanthine oxidase activity is one of the prime sources of superoxide.	Oxygen	71-77	xanthine dehydrogenase	Mus musculus	111-127
6093764-4	1984	It was proposed that allopurinol, a xanthine oxidase inhibitor, would decrease the rate of superoxide formation thus delaying the onset of oxygen-induced seizures.	Oxygen	139-145	xanthine dehydrogenase	Mus musculus	36-52
6316150-1	1983	Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper.	Oxygen	137-143	immunoglobulin kappa variable 1D-39	Homo sapiens	119-122
20804862-6	2010	Similarly, catalase treatment of PPHN lambs ventilated with 100% O2 decreased PDE5 activity and increased cGMP in PA. We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN.	Oxygen	65-67	catalase	Ovis aries	11-19
21143941-15	2010	Instead, a general pattern of ongoing horizontal transmission emerges wherein environmental and enzyme operational constraints, especially the presence or absence of oxygen, are likely to be major determinants of the RNR repertoire of genomes.	Oxygen	166-172	nuclear receptor subfamily 2 group E member 3	Homo sapiens	217-220
6640844-7	1983	It is concluded that active oxygen species play a role in ODC induction by factors contained in serum and by PMA.	Oxygen	28-34	ornithine decarboxylase, structural 1	Mus musculus	58-61
6442774-2	1984	Albumin inhibited oxygen consumption by soybean lipoxygenase.	Oxygen	18-24	linoleate 9S-lipoxygenase-4	Glycine max	48-60
21067176-0	2010	Selective oxygen-plasma-etching technique for the formation of ZnO-FTO heterostructure nanotubes and their rectified photocatalytic properties.	Oxygen	10-16	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	67-70
6330202-5	1984	In fact, impairment of M phi suppression by IFN-alpha occurred in parallel to the decrease of M phi capacity to produce PGE2 and the oxygen intermediate O2-, two molecules responsible for M phi-suppressive activity.	Oxygen	133-139	interferon alpha	Mus musculus	44-53
6330202-5	1984	In fact, impairment of M phi suppression by IFN-alpha occurred in parallel to the decrease of M phi capacity to produce PGE2 and the oxygen intermediate O2-, two molecules responsible for M phi-suppressive activity.	Oxygen	153-155	interferon alpha	Mus musculus	44-53
21067176-1	2010	A novel ZnO-FTO heterostructure nanotube array was produced by combining a chemical solution process with oxygen-plasma etching.	Oxygen	106-112	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	12-15
21067176-3	2010	X-ray photoelectron spectroscopy analysis demonstrated that the oxygen-plasma treatment decreased the O(2-)/OH(-) concentration ratio, resulting in dissociation of the Zn-O bonds and the outward diffusion of Zn cations to form an interior hollow, which is related to the formation of the hydroxyl functional group, Sn-OH, at the FTO surface.	Oxygen	64-70	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	329-332
21067176-3	2010	X-ray photoelectron spectroscopy analysis demonstrated that the oxygen-plasma treatment decreased the O(2-)/OH(-) concentration ratio, resulting in dissociation of the Zn-O bonds and the outward diffusion of Zn cations to form an interior hollow, which is related to the formation of the hydroxyl functional group, Sn-OH, at the FTO surface.	Oxygen	102-107	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	329-332
6089382-2	1984	It was determined that NADPH-cytochrome P-450 reductase may be the enzyme responsible for this reduction and that this free radical reacts rapidly with oxygen to produce superoxide.	Oxygen	152-158	cytochrome p450 oxidoreductase	Rattus norvegicus	23-55
21069992-5	2010	Deprotection of the C-7 oxygen function to the corresponding naphthol allows tautomerization to cyclohepta[de]naphthalene-1-ones upon seven-membered-ring closure in most cases, and replacement of the C-2 oxygen function in the naphthalene by a methyl group ultimately allows the synthesis of (+-)-microstegiol.	Oxygen	24-30	complement C2	Homo sapiens	200-203
6090312-5	1984	A cyclo-oxygenase introduces oxygen at C-11 and converts the resulting peroxy compound into a 9, 11-endoperoxide structure.	Oxygen	8-14	RNA polymerase III subunit K	Homo sapiens	39-43
6090312-7	1984	Other enzymes, the lipoxygenases, may instead introduce oxygen at C-5, C-8, C-9, C-12 or C-15: further conversions from, for example, the initially formed 5- or 15-hydroperoxy acids may lead to the leukotrienes.	Oxygen	22-28	complement C9	Homo sapiens	76-79
21069992-5	2010	Deprotection of the C-7 oxygen function to the corresponding naphthol allows tautomerization to cyclohepta[de]naphthalene-1-ones upon seven-membered-ring closure in most cases, and replacement of the C-2 oxygen function in the naphthalene by a methyl group ultimately allows the synthesis of (+-)-microstegiol.	Oxygen	204-210	complement C2	Homo sapiens	200-203
6090312-7	1984	Other enzymes, the lipoxygenases, may instead introduce oxygen at C-5, C-8, C-9, C-12 or C-15: further conversions from, for example, the initially formed 5- or 15-hydroperoxy acids may lead to the leukotrienes.	Oxygen	22-28	placenta associated 8	Homo sapiens	89-93
20693317-4	2010	We first demonstrated that miR-21 expression increased by ~3-fold in human PASMC after 6 h of hypoxia (3% O2) and remained high (~2-fold) after 24 h of hypoxia.	Oxygen	106-108	microRNA 21	Homo sapiens	27-33
6330372-3	1984	Cellular injuries induced by reoxygenation, "Oxygen paradox", were partially prevented by scavengers of H2O2 (glutathione reduced form, catalase) and O-2 (superoxide dismutase).	Oxygen	45-51	immunoglobulin kappa variable 1D-39	Homo sapiens	150-153
6141861-7	1984	It is concluded that a continuous infusion of somatostatin in patients with liver cirrhosis and portal hypertension causes a decreased hepatic blood flow with augmented hepatic oxygen extraction and a modest reduction in mean wedged hepatic venous pressure.	Oxygen	177-183	somatostatin	Homo sapiens	46-58
21290840-2	2010	METHODS: The oxygen partial pressure in acupoints [see text for formula] and in their corresponding non-acupoints of the Bladder Meridian was observed with the needle-type tissue oxygen tension sensor in the gap junction blocking goats by 1-Heptanol injection and the Connexin 43 (Cx43) gene knockout mice.	Oxygen	13-19	gap junction alpha-1 protein	Capra hircus	268-279
21290840-2	2010	METHODS: The oxygen partial pressure in acupoints [see text for formula] and in their corresponding non-acupoints of the Bladder Meridian was observed with the needle-type tissue oxygen tension sensor in the gap junction blocking goats by 1-Heptanol injection and the Connexin 43 (Cx43) gene knockout mice.	Oxygen	13-19	gap junction alpha-1 protein	Capra hircus	281-285
6496042-5	1984	In spite of the variations in red cell 2,3-DPG, hemoglobin-oxygen affinity expressed as P50 at actual pH remained unchanged during pregnancy and post partum.	Oxygen	59-65	activating signal cointegrator 1 complex subunit 1	Homo sapiens	88-91
6375300-0	1984	Retinal oxygen tension in diabetic dogs following insulin infusion.	Oxygen	8-14	insulin	Canis lupus familiaris	50-57
6418564-1	1983	Large white pig and human blood oxygen affinities are different due to different primary structures of hemoglobin.	Oxygen	32-38	HGB	Sus scrofa	103-113
21290840-2	2010	METHODS: The oxygen partial pressure in acupoints [see text for formula] and in their corresponding non-acupoints of the Bladder Meridian was observed with the needle-type tissue oxygen tension sensor in the gap junction blocking goats by 1-Heptanol injection and the Connexin 43 (Cx43) gene knockout mice.	Oxygen	179-185	gap junction alpha-1 protein	Capra hircus	268-279
6418564-2	1983	Empirical equations are reported to predict the oxygen partial pressure at half-saturation of hemoglobin (p50) from known values for pH, pCO2 and 2,3-diphosphoglycerate, with an accuracy of +/- 0.82 torr.	Oxygen	48-54	HGB	Sus scrofa	94-104
21290840-2	2010	METHODS: The oxygen partial pressure in acupoints [see text for formula] and in their corresponding non-acupoints of the Bladder Meridian was observed with the needle-type tissue oxygen tension sensor in the gap junction blocking goats by 1-Heptanol injection and the Connexin 43 (Cx43) gene knockout mice.	Oxygen	179-185	gap junction alpha-1 protein	Capra hircus	281-285
21290840-5	2010	(3) The oxygen partial pressure in acupoints of the Bladder Meridian was significantly higher than that in the non-acupoint controls in Cx43 wild type (WT) mice (all P &lt; 0.01).	Oxygen	8-14	gap junction alpha-1 protein	Capra hircus	136-140
20964307-8	2010	The magnetic ordering temperature decreases monotonously with increasing oxygen deficiency, while pronounced extrema are observed for the paramagnetic moment and the Curie-Weiss temperature at an oxygen deficiency delta   0.10, which corresponds to the P2(1)/n   I2/m phase transformation.	Oxygen	196-202	H3 histone pseudogene 16	Homo sapiens	253-258
6666843-3	1983	During anaesthesia (fentanyl, pancuronium bromide, ventilation with N2O/O2 1: 1) there was a decrease in CI (26%), SI (18%), HR (5,7%), dp/dt (15%) and an increase in TSR (25%) and TPR (32%); Part, PAP, PCWP and PRA remained unchanged.	Oxygen	72-74	translocated promoter region, nuclear basket protein	Homo sapiens	181-184
6354920-4	1983	Analysis of the phagocytosis-dependent H2O2 production by IFN-beta-treated M phi demonstrated a strong impairment of the oxygen metabolite release, which strictly paralleled the decreased M phi suppressive capacity.	Oxygen	121-127	interferon beta 1, fibroblast	Mus musculus	58-66
6354920-7	1983	Thus, IFN-beta appears as modulating both suppressive and antibacterial capacities of M phi through reduction of their oxygen metabolism, whereas regulation of M phi anti-tumour activity is possibly controlled by different mechanisms.	Oxygen	119-125	interferon beta 1, fibroblast	Mus musculus	6-14
20942497-0	2010	Theoretical study of the O2 interaction with a tetrahedral Al4 cluster.	Oxygen	25-27	G antigen 7	Homo sapiens	59-62
6556194-2	1983	Human plasma kallikrein has been shown to stimulate neutrophil chemotaxis, aggregation, and oxygen consumption.	Oxygen	92-98	kallikrein related peptidase 4	Homo sapiens	13-23
20942497-1	2010	Employing both multireference configuration interaction (MRCI) and density functional theory (DFT) methods, we have studied the interaction of O2 with a tetrahedral Al4 cluster in the total spin triplet state.	Oxygen	143-145	G antigen 7	Homo sapiens	165-168
20593371-4	2010	In this work, alveolar oxygen partial pressure measurements based on Carr-Purcell-Meiboom-Gill R(2) values of hyperpolarized (3) He and (129) Xe in vitro and in vivo in the rat lung at low magnetic field strength (74 mT) are presented.	Oxygen	23-29	arrestin 3	Rattus norvegicus	69-73
6311895-4	1983	Analysis of the modulation by MAF and IFN-beta of M phi diameter ability to release the oxygen metabolites O2- and H2O2, molecules possibly involved in the effector mechanism of both M phi diameter cytotoxicity and suppression, revealed a close correlation with the patterns of suppressive activity in both nondefective and defective strains.	Oxygen	88-94	interferon beta 1, fibroblast	Mus musculus	38-46
6311895-4	1983	Analysis of the modulation by MAF and IFN-beta of M phi diameter ability to release the oxygen metabolites O2- and H2O2, molecules possibly involved in the effector mechanism of both M phi diameter cytotoxicity and suppression, revealed a close correlation with the patterns of suppressive activity in both nondefective and defective strains.	Oxygen	107-109	interferon beta 1, fibroblast	Mus musculus	38-46
20689064-8	2010	Analysis of oxygen-induced retinopathy mediators revealed that angiopoietin-2 expression is significantly reduced in the absence of Notch3.	Oxygen	12-18	angiopoietin 2	Mus musculus	63-77
6136977-2	1983	This report is an attempt to correlate genotypic fluctuations at Hbb with a most important physiological attribute of haemoglobin, its oxygen carrying capacity.	Oxygen	135-141	hemoglobin beta chain complex	Mus musculus	65-68
6136977-6	1983	In general, the blood of mice of inbred strains as well as wild-caught mice that are homozygous for Hbbd tends to have a higher oxygen affinity than that from comparable animals homozygous for Hbbs, but it seems likely that the oxygen dissociation properties of haemoglobin are not the only ones important in determining differential survival of a particular Hbb type under varying environmental stress.	Oxygen	128-134	hemoglobin beta chain complex	Mus musculus	100-103
6136977-6	1983	In general, the blood of mice of inbred strains as well as wild-caught mice that are homozygous for Hbbd tends to have a higher oxygen affinity than that from comparable animals homozygous for Hbbs, but it seems likely that the oxygen dissociation properties of haemoglobin are not the only ones important in determining differential survival of a particular Hbb type under varying environmental stress.	Oxygen	228-234	hemoglobin beta chain complex	Mus musculus	100-103
20935666-8	2010	UCP1 is an inner mitochondrial membrane protein that short circuits the mitochondrial proton gradient, so that oxygen consumption is no longer coupled to adenosine triphosphate synthesis.	Oxygen	111-117	uncoupling protein 1	Homo sapiens	0-4
6871231-7	1983	A correlation was found between the inhibition of O2- formation caused by the SH reagent p-chloromercuribenzoate and the alterations induced by this compound on the Em of cytochrome b.	Oxygen	50-52	cytochrome b	Cavia porcellus	171-183
20630870-10	2010	In parallel, we show that Tpa1 represses the expression of genes regulated by Hap1, a transcription factor involved in the response to levels of heme and oxygen.	Oxygen	154-160	oxidative DNA demethylase	Saccharomyces cerevisiae S288C	26-30
6602802-9	1983	This novel form of regulation of ferritin gene expression can be attributed to a need to protect DNA from degradation by iron and oxygen.	Oxygen	130-136	Fer2	Triticum aestivum	33-41
20630870-10	2010	In parallel, we show that Tpa1 represses the expression of genes regulated by Hap1, a transcription factor involved in the response to levels of heme and oxygen.	Oxygen	154-160	Hap1p	Saccharomyces cerevisiae S288C	78-82
20630870-11	2010	Altogether, our results support that Tpa1 is a putative enzyme acting as an oxygen sensor and influencing several distinct regulatory pathways.	Oxygen	76-82	oxidative DNA demethylase	Saccharomyces cerevisiae S288C	37-41
6194549-7	1983	It is suggested that faster rate of release of O2 from Hb B may be due to its having lysine at position HCl in the beta-chain whereas the other haemoglobins have arginine.	Oxygen	47-49	hemoglobin subunit beta	Ovis aries	55-59
6840848-1	1983	Immune sensitization of spleen cells was required to generate lymphokines (LK) that activated thioglycolate-elicited peritoneal macrophages (thio MACs) to respond via both oxygen-dependent and oxygen-independent systems.	Oxygen	172-178	myristoylated alanine rich protein kinase C substrate	Mus musculus	146-150
6840848-1	1983	Immune sensitization of spleen cells was required to generate lymphokines (LK) that activated thioglycolate-elicited peritoneal macrophages (thio MACs) to respond via both oxygen-dependent and oxygen-independent systems.	Oxygen	193-199	myristoylated alanine rich protein kinase C substrate	Mus musculus	146-150
20638309-0	2010	Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration.	Oxygen	80-86	phenylalanine hydroxylase	Rattus norvegicus	0-25
6342662-1	1983	Experiments were done to measure the ability of dioxygen to collisionally quench the phosphorescent and fluorescent tryptophans in alcohol dehydrogenase and alkaline phosphatase.	Oxygen	48-56	aldo-keto reductase family 1 member A1	Homo sapiens	131-152
6359947-2	1983	Weaning from controlled mechanical ventilation (CMV) in the postoperative period is commonly performed by a CPAP system in order to restore the impaired oxygen exchange.	Oxygen	153-159	centromere protein J	Homo sapiens	108-112
6413652-2	1983	A moderate, significant increase of CO2 production was seen only in the CA3 region hippocampal preparation at kainic acid concentrations of 10(-4)-10(-2) M. The O2 consumption, at the expense of endogenous energy stores of whole hippocampal slices, was substantially increased by 10(-3) M kainic acid when the slices were incubated without exogenous glucose.	Oxygen	37-39	carbonic anhydrase 3	Rattus norvegicus	72-75
20638309-1	2010	In this work we have investigated the regulation of rat phenylalanine hydroxylase (rPAH) expression by oxygen in primary cultures of rat hepatocytes.	Oxygen	103-109	phenylalanine hydroxylase	Rattus norvegicus	56-81
6891602-9	1982	The results demonstrate that molecular alterations in the cytochrome b region of the respiratory chain caused by ethanol feeding are present in intact liver cells, but suggest that substrate accessibility, rather than the respiratory chain, limits the rate of oxygen utilization in isolated hepatocytes.	Oxygen	260-266	cytochrome b, mitochondrial	Rattus norvegicus	58-70
20638309-1	2010	In this work we have investigated the regulation of rat phenylalanine hydroxylase (rPAH) expression by oxygen in primary cultures of rat hepatocytes.	Oxygen	103-109	phenylalanine hydroxylase	Rattus norvegicus	83-87
20607367-1	2010	PURPOSE: A hypoxia-inducible VEGF expression system with the oxygen-dependent degradation (ODD) domain was constructed and tested to be used in gene therapy for ischemic myocardial disease.	Oxygen	61-67	vascular endothelial growth factor A	Rattus norvegicus	29-33
6295574-3	1982	Also involved in the O-.2-forming reaction is a b-type cytochrome; the role of this cytochrome is as yet undefined, though it does not appear to be on the direct route of electron transfer between NADPH and oxygen.	Oxygen	207-213	immunoglobulin kappa variable 1D-39	Homo sapiens	21-25
7085677-7	1982	This cytochrome displays the highest activity of all of the rabbit isozymes in the oxidation of ethanol to acetaldehyde and the p-hydroxylation of aniline when reconstituted with NADPH-cytochrome P-450 reductase and phospholipid in the presence of NADPH and oxygen.	Oxygen	258-264	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	179-211
6623364-3	1983	CPAP/IMV patients had better oxygen tension, reduced physiologic shunting in the lung (24% versus 18%), and an improved arterial tension: inspired oxygen concentration ratio.	Oxygen	29-35	centromere protein J	Homo sapiens	0-4
6623364-3	1983	CPAP/IMV patients had better oxygen tension, reduced physiologic shunting in the lung (24% versus 18%), and an improved arterial tension: inspired oxygen concentration ratio.	Oxygen	147-153	centromere protein J	Homo sapiens	0-4
6623364-6	1983	Consequently, the total oxygen delivery was reduced for all 3 days following insult and for the cumulative data for all 3 days (266 versus 306 ml/min) in the CPAP/IMV patients.	Oxygen	24-30	centromere protein J	Homo sapiens	158-162
6623364-7	1983	Oxygen consumption was also reduced in the CPAP/IMV patients; this reduction was not significant for each of the first 3 days but was significant when the data for the 3 days were added to the analysis (306 versus 272 ml/min).	Oxygen	0-6	centromere protein J	Homo sapiens	43-47
20607367-8	2010	The enhancement of VEGF protein production was attributed to increased protein stability due to oxygen deficiency.	Oxygen	96-102	vascular endothelial growth factor A	Rattus norvegicus	19-23
6626508-1	1983	2-Hydroxy-3-undecyl-1,4-naphthoquinone is a quinone analogue that inhibits mitochondrial respiration in the cytochrome b-c1 region with an apparent Ki of 2.5 X 10(-7) M. In electron transport particles, it prevents the reduction of cytochrome c1 by succinate but not its oxidation by oxygen and prevents oxidation of cytochrome b but not its reduction by succinate.	Oxygen	284-290	mitochondrially encoded cytochrome b	Homo sapiens	108-120
7118875-11	1982	Evidence was obtained that the hydrocarbons were bound at the substrate site in the heme-containing domain of the monooxygenase, P-448(1), and metabolized by the aid of NADPH-cytochrome P-450 reductase in the presence of NADPH and O2.	Oxygen	231-233	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	169-201
20701279-8	2010	For example, ascorbic acid can directly reduce alpha-syn-Cu(2+) to alpha-syn-Cu(+), setting up a redox cycle in which O(2) is reduced to H(2)O(2) and cellular redox species is continuously exhausted.	Oxygen	118-122	synuclein alpha	Homo sapiens	47-56
24458229-2	1982	Bean chloroplasts treated with galactolipase (lipolytic acyl hydrolase) isolated from bean leaves showed an inhibition of photosystem I activity as measured by methyl viologen-mediated oxygen uptake and NADP(+) photoreduction.	Oxygen	185-191	brain expressed associated with NEDD4 1	Homo sapiens	0-4
6622860-1	1983	Enhancement of oxygen flux through myoglobin containing solutions due to myoglobin facilitated oxygen diffusion is well recognized and is most apparent under conditions of hypoxia.	Oxygen	15-21	myoglobin	Canis lupus familiaris	35-44
6622860-1	1983	Enhancement of oxygen flux through myoglobin containing solutions due to myoglobin facilitated oxygen diffusion is well recognized and is most apparent under conditions of hypoxia.	Oxygen	15-21	myoglobin	Canis lupus familiaris	73-82
6622860-1	1983	Enhancement of oxygen flux through myoglobin containing solutions due to myoglobin facilitated oxygen diffusion is well recognized and is most apparent under conditions of hypoxia.	Oxygen	95-101	myoglobin	Canis lupus familiaris	35-44
24458229-2	1982	Bean chloroplasts treated with galactolipase (lipolytic acyl hydrolase) isolated from bean leaves showed an inhibition of photosystem I activity as measured by methyl viologen-mediated oxygen uptake and NADP(+) photoreduction.	Oxygen	185-191	pancreatic lipase related protein 2 (gene/pseudogene)	Homo sapiens	31-44
24458229-2	1982	Bean chloroplasts treated with galactolipase (lipolytic acyl hydrolase) isolated from bean leaves showed an inhibition of photosystem I activity as measured by methyl viologen-mediated oxygen uptake and NADP(+) photoreduction.	Oxygen	185-191	brain expressed associated with NEDD4 1	Homo sapiens	86-90
6622860-1	1983	Enhancement of oxygen flux through myoglobin containing solutions due to myoglobin facilitated oxygen diffusion is well recognized and is most apparent under conditions of hypoxia.	Oxygen	95-101	myoglobin	Canis lupus familiaris	73-82
6622860-6	1983	Hydrogen peroxide administration resulted in oxidation of intracellular myoglobin with a resultant decrease of 37% in muscle oxygen consumption and 42% in tension generation after 20 min of stimulation.	Oxygen	125-131	myoglobin	Canis lupus familiaris	72-81
6683474-1	1983	It is possible to assay for trans-7,8-dihydroxy 7,8-dihydrobenzo[a]-pyrene (BP-7,8-dihydrodiol) in complex metabolite mixtures produced during microsomal metabolism of benzo[a]pyrene (BP) because only the BP-7,8-dihydrodiol metabolite will produce significant chemiluminescence (CL) in the NaOCl-H2O2 singlet oxygen-generating system.	Oxygen	309-315	BP7	Homo sapiens	76-80
7093200-4	1982	In addition, PB-1-1 catalyzed oxygen transfer to the p-methyl group of the sulfide substrates to yield the (ethylthio)benzyl alcohol with a turnover of 6.8 min-1, corresponding to a sulfur:carbon oxygenation partition ratio of 6:1.	Oxygen	30-36	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	13-19
20701279-8	2010	For example, ascorbic acid can directly reduce alpha-syn-Cu(2+) to alpha-syn-Cu(+), setting up a redox cycle in which O(2) is reduced to H(2)O(2) and cellular redox species is continuously exhausted.	Oxygen	118-122	synuclein alpha	Homo sapiens	67-76
7071598-3	1982	It is concluded that functional intracellular myoglobin is important in maintaining oxygen consumption and tension generation in exercising skeletal muscle.	Oxygen	84-90	myoglobin	Canis lupus familiaris	46-55
20427335-0	2010	Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts.	Oxygen	15-21	fos-like antigen 2	Mus musculus	0-5
7074087-1	1982	Initial rate measurements were made of the oxidation of D-lactate and D-alpha-hydroxybutyrate by oxygen and potassium ferricyanide, catalyzed by D-lactate dehydrogenase from Megasphera elsdenii.	Oxygen	97-103	lactate dehydrogenase D	Homo sapiens	145-168
7074088-1	1982	The reaction of oxidized D-lactate dehydrogenase with D-lactate and reduced D-lactate dehydrogenase with pyruvate and oxygen was studied in a stopped-flow spectrophotometer.	Oxygen	118-124	lactate dehydrogenase D	Homo sapiens	25-48
7074088-1	1982	The reaction of oxidized D-lactate dehydrogenase with D-lactate and reduced D-lactate dehydrogenase with pyruvate and oxygen was studied in a stopped-flow spectrophotometer.	Oxygen	118-124	lactate dehydrogenase D	Homo sapiens	76-99
6186695-1	1983	When non-malignant cells were reacted for glucose-6-phosphate dehydrogenase activity, with neotetrazolium chloride as the indicator of the activity, oxygen competed with the neotetrazolium and nullified the reaction.	Oxygen	149-155	glucose-6-phosphate dehydrogenase	Homo sapiens	42-75
6878384-0	1983	The physiologic effects of oxygen transport by hemoglobin solutions.	Oxygen	27-33	HGB	Sus scrofa	47-57
20427335-8	2010	Knockdown of Fra-2 significantly blunted O(2)-induced expression of TGFbeta1 as well as TGFbeta3 in CF.	Oxygen	41-45	fos-like antigen 2	Mus musculus	13-18
6878384-11	1983	Results from these three studies substantiate a significant benefit to animals undergoing a 50% exchange when that exchange is done with an oxygen carrying solution such as stroma-free hemoglobin solutions as opposed to a non-oxygen carrying but oncotically active solution such as albumin solution.	Oxygen	140-146	HGB	Sus scrofa	185-195
6295572-1	1982	The spectrum of biological processes in which oxygen is used by living systems is quite large, and the products include some damaging species of activated oxygen, particularly the superoxide radical (O-.2) and hydrogen peroxide (H2O2).	Oxygen	46-52	immunoglobulin kappa variable 1D-39	Homo sapiens	200-204
7085543-2	1982	In the method, uricase is used to decompose the uric acid; the reaction is monitored with an oxygen-sensitive electrode.	Oxygen	93-99	urate oxidase (pseudogene)	Homo sapiens	15-22
20427335-8	2010	Knockdown of Fra-2 significantly blunted O(2)-induced expression of TGFbeta1 as well as TGFbeta3 in CF.	Oxygen	41-45	transforming growth factor, beta 3	Mus musculus	88-96
6295572-1	1982	The spectrum of biological processes in which oxygen is used by living systems is quite large, and the products include some damaging species of activated oxygen, particularly the superoxide radical (O-.2) and hydrogen peroxide (H2O2).	Oxygen	155-161	immunoglobulin kappa variable 1D-39	Homo sapiens	200-204
6295572-4	1982	Formation, interconversion, and reactivity of O-.2 and related activated oxygen species, methods available for their detection, and the basis of their biological toxicity are briefly reviewed.	Oxygen	73-79	immunoglobulin kappa variable 1D-39	Homo sapiens	46-50
20427335-10	2010	Collectively, these observations point towards a central role of Ask-1 and Fra-2 in O(2)-inducible AP-1 activation and induction of TGFbeta.	Oxygen	84-88	mitogen-activated protein kinase kinase kinase 5	Mus musculus	65-70
20427335-10	2010	Collectively, these observations point towards a central role of Ask-1 and Fra-2 in O(2)-inducible AP-1 activation and induction of TGFbeta.	Oxygen	84-88	fos-like antigen 2	Mus musculus	75-80
6760780-6	1982	Optimal CPAP should be applied to improve matching of ventilation and perfusion and to improve pulmonary mechanics so that the requirement for oxygen and mechanical ventilation is reduced.	Oxygen	143-149	centromere protein J	Homo sapiens	8-12
6760780-7	1982	A reduction in inspired oxygen concentration may prevent absorption atelectasis and allow more rapid discontinuation of mechanical ventilation and CPAP.	Oxygen	24-30	centromere protein J	Homo sapiens	147-151
20622065-4	2010	Here we report mapping of the fadH promoter and document its complex regulation by three independent regulators, the fatty acid degradation FadR repressor, the oxygen-responsive ArcA-ArcB two-component system, and the cyclic AMP receptor protein-cyclic AMP (CRP-cAMP) complex.	Oxygen	160-166	hypothetical protein	Escherichia coli	183-187
7332932-4	1981	We demonstrate here that a salt-soluble protein of molecular weight 32,000 (b-32) is under control of O2.	Oxygen	102-104	Ribosome-inactivating protein 9	Zea mays	76-80
6291602-6	1982	The reduction of cytochrome b by substrate in particles treated with 2,3-dimercaptopropanol (BAL) + O2 is also sensitive to HMHQQ, with a KD value in between the two values given above.	Oxygen	100-102	mitochondrially encoded cytochrome b	Homo sapiens	17-29
20572162-3	2010	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1 alpha and HIF-1 beta, plays a critical role in oxygen homeostasis and is involved in angiogenesis and cell proliferation.	Oxygen	139-145	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	102-112
7093528-4	1982	Morphological observations suggested that the enhancement of O2- and H2O2 release was caused by excessive release of the oxygen metabolites into the extracellular medium from incompletely formed phagocytic vacuoles as was observed with cytochalasin-B-treated cells.	Oxygen	121-127	immunoglobulin kappa variable 1D-39	Homo sapiens	61-73
6285821-5	1982	Addition of superoxide dismutase or catalase to the O2.- generating system resulted in protection of thermally stressed and nonstressed cells, with the protective effect being greater for thermally stressed cells.	Oxygen	52-54	AT695_RS09750	Staphylococcus aureus	12-32
6285821-5	1982	Addition of superoxide dismutase or catalase to the O2.- generating system resulted in protection of thermally stressed and nonstressed cells, with the protective effect being greater for thermally stressed cells.	Oxygen	52-54	AT695_RS10915	Staphylococcus aureus	36-44
7315740-2	1981	Interlocking O2 absorption and sulfide depletion data indicate that both oxyhemoglobin and methemoglobin are effective catalytic agents.	Oxygen	13-15	hemoglobin subunit gamma 2	Homo sapiens	91-104
7315740-4	1981	It has also been established that the formation of methemoglobin following nitrite administration occurs preferentially under oxygen poor conditions.	Oxygen	126-132	hemoglobin subunit gamma 2	Homo sapiens	51-64
7298444-1	1981	We have studied the effect of hypoxia [inspired partial pressure of O2 (Po2) 50 mmHg] on the relationships among pulmonary blood flow, pulmonary arterial pressure, and fluid filtration rates in isolated blood-perfused pig lungs.	Oxygen	68-70	PO2	Sus scrofa	72-75
6917855-6	1982	In addition, PMN incubation with kallikrein resulted in stimulation of their oxidative metabolism as assessed by an increased oxygen uptake.	Oxygen	126-132	kallikrein related peptidase 4	Homo sapiens	33-43
21152835-5	2010	When oxygen delivery is inadequate, hepcidin levels decrease.	Oxygen	5-11	hepcidin antimicrobial peptide	Homo sapiens	36-44
10315177-1	1982	We have developed a valved gas collection assembly for high-flow CPAP systems that permits the isolation of expired gases for the analysis and computation of oxygen uptake and carbon dioxide production.	Oxygen	158-164	centromere protein J	Homo sapiens	65-69
7024025-11	1981	Rapid reduction of alloxan by thioredoxin in the presence of molecular oxygen and NADPH leads to strong chemiluminescence from luminol indicative of an intense radical protection.	Oxygen	71-77	thioredoxin 1	Mus musculus	30-41
20675542-5	2010	Thus, by controlling the NO(*) bioavailability via scavenging or formation, myoglobin serves as part of a sensitive dioxygen sensory system.	Oxygen	116-124	myoglobin	Homo sapiens	76-85
7020766-1	1981	The effects of various electron carriers, a substrate (H2) and a reversible inhibitor (CO) on the rate of irreversible oxygen inactivation of clostridial hydrogenase (ferredoxin: H+ oxidoreductase, EC 1.18.3.1) have been studied kinetically.	Oxygen	119-125	thioredoxin reductase 1	Homo sapiens	182-196
6212952-1	1982	Changes in the respiratory frequency and heart rate in response to 10 seconds" inflation of the lungs with oxygen by the CPAP method were studied in 32 premature neonates.	Oxygen	107-113	centromere protein J	Homo sapiens	121-125
20675542-7	2010	Detrimental and beneficial effects of the presence of myoglobin are discussed for various states of tissue oxygen tension within the heart and skeletal muscle.	Oxygen	107-113	myoglobin	Homo sapiens	54-63
7021526-5	1981	It was suggested that the efficient removal of oxygen from the medium allowed the lon cells to repair radiation-induced damage to the septation mechanism.	Oxygen	47-53	putative ATP-dependent Lon protease	Escherichia coli	82-85
7236701-1	1981	Oxygen equilibrium of Hb Toyoake (142 (H20)beta, Ala leads to Pro) is characterized by an oxygen affinity 6-times higher than that of Hb A, a slightly decreased alkaline Bohr effect, diminished cooperativity, with Hill"s coefficient decreased by 1.2, and reduced response to 2,3-diphosphoglycerate and inositol hexaphosphate.	Oxygen	0-6	sodium voltage-gated channel alpha subunit 2	Homo sapiens	134-138
20675543-3	2010	Prior studies incorporating molecular, pharmacological, physiological and transgenic technologies have demonstrated that myoglobin is an essential oxygen-storage hemoprotein capable of facilitating oxygen transport and modulating nitric oxide homeostasis within cardiac and skeletal myocytes.	Oxygen	147-153	myoglobin	Homo sapiens	121-130
7236701-3	1981	The heat of oxygenation was -13.5 kcal/mol for Hb Toyoake and -12.9 kcal/mol for Hb A at pH 7.4 in 0.1 M Cl- and they became equal when corrected for the heat of oxygen-linked proton and Cl- release.	Oxygen	12-18	sodium voltage-gated channel alpha subunit 2	Homo sapiens	81-85
7263436-5	1981	Ventilation with 10% O2 resulted in a significant increase in lobar PAP [12.2 +/- 1.6 to 17.2 +/- 1.2 (SE) Torr] and PVR [42.2 +/- 13.3 to 61.2 +/- 15.0 (SE) Torr X 1(-1) X min].	Oxygen	21-23	PVR cell adhesion molecule	Canis lupus familiaris	117-120
20660313-2	2010	The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1alpha and HIF-2alpha are overexpressed in many human NSCLCs, and constitutive HIF-2alpha activity can promote murine lung tumor progression, suggesting that HIF proteins may be effective NSCLC therapeutic targets.	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	94-104
6457505-8	1981	The activity of biochemically determined phosphofructokinase (PFK) was the same in both muscles and in all groups; succinate dehydrogenase activity (SDH) was closely related to maximal oxygen uptake.	Oxygen	185-191	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	149-152
7195011-5	1981	Under these conditions H is the sum of the enthalpies due to a) alactic sources (Hal), i.e., net approximately P depletion and muscle O2 stores utilization, and b) formation: H = Hal + "delta HLa" .	Oxygen	134-136	histidine ammonia-lyase	Canis lupus familiaris	81-84
7195011-5	1981	Under these conditions H is the sum of the enthalpies due to a) alactic sources (Hal), i.e., net approximately P depletion and muscle O2 stores utilization, and b) formation: H = Hal + "delta HLa" .	Oxygen	134-136	histidine ammonia-lyase	Canis lupus familiaris	179-182
20660313-2	2010	The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1alpha and HIF-2alpha are overexpressed in many human NSCLCs, and constitutive HIF-2alpha activity can promote murine lung tumor progression, suggesting that HIF proteins may be effective NSCLC therapeutic targets.	Oxygen	4-10	endothelial PAS domain protein 1	Homo sapiens	162-172
20525878-2	2010	Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1alpha protein, an oxygen-sensitive subunit of HIF-1 that is a master factor for cellular response to hypoxia, significantly increases galectin-1 expression in both messenger RNA and protein levels in all four colorectal cancer (CRC) cell lines tested.	Oxygen	91-97	galectin 1	Homo sapiens	207-217
6260196-2	1981	Incubation in the presence of 2-oxoglutarate and oxygen inactivates prolyl 4-hydroxylase (prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, EC 1.14.11.2), with a t 1/2 of 80 s at 37 degrees C. This inactivation is not affected by the presence or absence of the prolyl peptide substrate or added Fe(II).	Oxygen	49-55	thioredoxin reductase 1	Homo sapiens	135-149
7202682-0	1981	Methemoglobin formation and reduction in relation to hemoglobin oxygen affinity.	Oxygen	64-70	hemoglobin subunit gamma 2	Homo sapiens	0-13
6972447-7	1981	However, adenosine deaminase, which inactivates adenosine by removing the amino group, increased oxygen uptake, calcium content and lactate release of these muscles.	Oxygen	97-103	adenosine deaminase	Homo sapiens	9-28
6262301-0	1981	Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen.	Oxygen	148-154	2,4-dienoyl-CoA reductase 1	Homo sapiens	57-62
20497231-4	2010	Blood-oxygen-level-dependent response was measured with functional magnetic resonance imaging during a rejection-themed emotional Stroop task in 19 adolescents (aged 14-16) and 16 adults (aged 23-28) genotyped for MAOA polymorphism.	Oxygen	6-12	monoamine oxidase A	Homo sapiens	214-218
7262818-11	1981	The delta 6-desaturase activity required NADH (or NADPH), linoleoyl-CoA, oxygen, lipid or detergent and three enzymes, such as NADH-cytochrome b5 reductase (or NADPH-cytochrome P -450 reductase), cytochrome b5, and delta 6-desaturase.	Oxygen	73-79	cytochrome b5 type A	Rattus norvegicus	132-145
6937515-2	1981	The required components were: 1) peroxidase activity and thiocyanate ion (SCN-), 2) the saliva sediment, which produced hydrogen peroxide (H2O2) in the presence of oxygen and a divalent cation, and 3) heat-stable factors of the saliva supernatant.	Oxygen	164-170	growth factor independent 1 transcriptional repressor	Homo sapiens	74-82
7270163-5	1981	It is suggested that disturbed oxygen exchange due to poor development of the villous vessels causes a compensatory hyperplasia of the placenta at birth in CNF.	Oxygen	31-37	NPHS1 adhesion molecule, nephrin	Homo sapiens	156-159
7400118-2	1980	The reduction of methemoglobin by the reconstituted enzyme system could be easily detected with flavin at the physiological concentration (e.g., 0.1-1.0 microM), and the rates obtained with 0.1 and 1.0 microM FMN were 0.19 and 2.2 nmol heme reduced per min per ml, respectively, in the absence of oxygen.	Oxygen	297-303	hemoglobin subunit gamma 2	Homo sapiens	17-30
6770893-5	1980	The Ca2+ and Mg2+ affinities may further be altered by replacing the ether oxygens by heterocyclic nitrogen atoms.	Oxygen	75-82	carbonic anhydrase 2	Homo sapiens	4-7
20444557-0	2010	High-oxygen modified atmosphere packaging system induces lipid and myoglobin oxidation and protein polymerization.	Oxygen	5-11	myoglobin	Homo sapiens	67-76
7356629-3	1980	When D-[2-18O]ribulose 1,5-bisphosphate was used, a significant amount of [1-18O]glycolate 2-phosphate was formed, indicating that O-2 of D-ribulose 1,5-bisphosphate is retained in the carboxyl oxygens of glycolate 2-phosphate.	Oxygen	194-201	immunoglobulin kappa variable 1D-39	Homo sapiens	131-134
7008611-10	1981	These alterations strongly suggest a significant role for insulin in the modulation of fetal carbohydrate metabolism and perhaps oxygen utilization.	Oxygen	129-135	LOC105613195	Ovis aries	58-65
7314119-0	1981	The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen.	Oxygen	129-135	suppressor of cytokine signaling 6	Mus musculus	45-50
20657781-2	2010	METHODOLOGY/PRINCIPAL FINDINGS: We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1alpha.	Oxygen	128-134	hypoxia inducible factor 1, alpha subunit	Mus musculus	151-161
6252740-5	1980	In case of matrix containing n-hexyl groups deoxyHb is oxidized by O2 to MetHb, instead of being oxygenated to HbO2.	Oxygen	67-69	hemoglobin subunit gamma 2	Homo sapiens	73-78
7441260-5	1980	Elevation of oxygen pressure above 1 atm  caused further increments in malonaldehyde production with kinetic properties similar to that seen at 1 atm pressure, but the increments per additional oxygen pressure were diminishing.	Oxygen	13-19	ATM serine/threonine kinase	Rattus norvegicus	37-40
20621831-1	2010	Oxidative protein folding in the luminal compartment of the endoplasmic reticulum is thought to be mediated by a proteinaceous electron relay system composed by PDI and ER oxidoreductin 1 (Ero1), transferring electrons from the cysteinyl residues of substrate proteins to oxygen.	Oxygen	272-278	peptidyl arginine deiminase 1	Homo sapiens	161-164
7441260-5	1980	Elevation of oxygen pressure above 1 atm  caused further increments in malonaldehyde production with kinetic properties similar to that seen at 1 atm pressure, but the increments per additional oxygen pressure were diminishing.	Oxygen	13-19	ATM serine/threonine kinase	Rattus norvegicus	146-149
7441260-6	1980	The formation of a given amount of malonaldehyde can be expressed as a function of atm oxygen X min.	Oxygen	87-93	ATM serine/threonine kinase	Rattus norvegicus	83-86
7378040-0	1980	Abnormal hemoglobin oxygen affinity and the coronary circulation.	Oxygen	20-26	hemoglobin subunit gamma 2	Homo sapiens	0-19
20513808-2	2010	The NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular metabolism in lipid synthesis, cellular defense against oxidative stress, oxidative respiration, and oxygen-sensing signal transduction.	Oxygen	210-216	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	57-61
16592753-2	1980	The observations prove that the free radicals produced by ionizing irradiation under vacuum at 300 K are converted by the oxygen to protein-peroxide free radicals X-O((1))-O((2)), with the unpaired electron density in a pi-type orbital predominantly on the peroxide group.	Oxygen	122-128	immunoglobulin kappa variable 2D-40	Homo sapiens	165-170
16592753-2	1980	The observations prove that the free radicals produced by ionizing irradiation under vacuum at 300 K are converted by the oxygen to protein-peroxide free radicals X-O((1))-O((2)), with the unpaired electron density in a pi-type orbital predominantly on the peroxide group.	Oxygen	122-128	immunoglobulin kappa variable 1D-39	Homo sapiens	172-177
7213489-3	1980	The oxygen consumption evaluated at 200 Watt shows a figure of 50 ml O2/min/Kg, whereas the maxim calculated VO2 goes up to 75,56 ml/min/Kg body weight.	Oxygen	4-10	immunoglobulin kappa variable 1D-39	Homo sapiens	69-78
7442940-0	1980	The effects of bombesin injected into The anterior and posterior hypothalamus on body temperature and oxygen consumption.	Oxygen	102-108	gastrin releasing peptide	Homo sapiens	15-23
20395290-6	2010	Our results position hypoxia-inducible factor-2alpha as a novel regulator of EGFR activation under low oxygen conditions, and suggest that hypoxia-induced EGFR signaling may promote a more aggressive phenotype in a fraction of HNSCC tumors.	Oxygen	103-109	endothelial PAS domain protein 1	Homo sapiens	21-52
7426319-4	1980	The oxidation of spermine in the presence of different concentrations of PAO was non-linear, which implied complex intermediate events for conversion of spermine to labile di-oxidized spermine (N,N"-bis(3-propionaldehyde)-1,4-butanediamine) with, perhaps, overall generation of free radicals (O(2) (- ) and  OH) which are damaging to cells.	Oxygen	293-302	polyamine oxidase	Homo sapiens	73-76
7426319-10	1980	Nevertheless, O(2) (- ) was generated during further PAO conversion and/or auto-oxidation of di-oxidized spermine.	Oxygen	14-23	polyamine oxidase	Homo sapiens	53-56
20590839-9	2010	Among all kinds of amino acid residues, methionine (Met) is the most susceptible to reactive oxygen species, and Met oxidation seems to occur in ordinary cellular circumstances because most cells contain Met sulfoxide reductases, which might prevent serious cellular damage.	Oxygen	93-99	SAFB like transcription modulator	Homo sapiens	52-55
513609-0	1979	[Polyvinylpyrolidone-fixed hemoglobin as an oxygen carrying blood substitute (author"s transl)].	Oxygen	44-50	HGB	Sus scrofa	27-37
513609-1	1979	The development of blood substitute oxygen carriers has branched off into several directions: stroma-free hemoglobin solutions, modelling of hemoglobin by fixation of heme or hemopeptides to polymers, filling of microcapsules with hemoglobin solution, crosslinking of hemoglobin.	Oxygen	36-42	HGB	Sus scrofa	106-116
43651-6	1979	Arteriovenous oxygen content difference decreased from 4.6 +/- 0.5 (CMV + PEEP) to 3.6 +/- 0.2 (CPAP) ml/100 ml (P less than 0.05), while total oxygen consumption remained unchanged.	Oxygen	14-20	centromere protein J	Homo sapiens	96-100
43651-9	1979	Our observations suggest that, in terms of central haemodynamics and tissue oxygen supply, CPAP offers a noteworthy alternative weaning method and an alternative to CMV + PEEP in cases where therapy is prolonged and the patient is able to breathe spontaneously.	Oxygen	76-82	centromere protein J	Homo sapiens	91-95
513609-1	1979	The development of blood substitute oxygen carriers has branched off into several directions: stroma-free hemoglobin solutions, modelling of hemoglobin by fixation of heme or hemopeptides to polymers, filling of microcapsules with hemoglobin solution, crosslinking of hemoglobin.	Oxygen	36-42	HGB	Sus scrofa	141-151
20620956-2	2010	The SIRT1 deacetylase and the HIF-1alpha transcription factor act as redox and oxygen sensors, respectively.	Oxygen	79-85	sirtuin 1	Mus musculus	4-9
513609-1	1979	The development of blood substitute oxygen carriers has branched off into several directions: stroma-free hemoglobin solutions, modelling of hemoglobin by fixation of heme or hemopeptides to polymers, filling of microcapsules with hemoglobin solution, crosslinking of hemoglobin.	Oxygen	36-42	HGB	Sus scrofa	141-151
513609-1	1979	The development of blood substitute oxygen carriers has branched off into several directions: stroma-free hemoglobin solutions, modelling of hemoglobin by fixation of heme or hemopeptides to polymers, filling of microcapsules with hemoglobin solution, crosslinking of hemoglobin.	Oxygen	36-42	HGB	Sus scrofa	141-151
513609-3	1979	In this paper synthesis and properties of an oxygen carrying blood substitute are described in which the hemoglobin molecule is covalently bound to polyvinylpyrrolidone.	Oxygen	45-51	HGB	Sus scrofa	105-115
37557-3	1979	Bovine liver xanthine oxidase and chicken liver xanthine dehydrogenase with oxygen as electron acceptor exhibit similar profile in pKM and log V versus pH plots.	Oxygen	76-82	pyruvate kinase, liver and RBC	Gallus gallus	131-134
670704-7	1978	The development of the delayed hypersensitivity reaction to myelin basic protein and to tuberculin is also suppressed by O2 therapy indicating that its effects upon autoimmune encephalomyelitis involves fundamental alterations of the cellular components of the immune response, some or all of which are reversible.	Oxygen	121-123	myelin basic protein	Rattus norvegicus	60-80
115475-0	1979	On the possible in vitro use of perfluoro compounds as oxygen reservoir for the microsomal monooxygenase system.	Oxygen	55-61	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	80-104
464052-7	1979	These observations suggest that glucose-induced insulin release is inhibited by acute severe hypoxia despite previous chronic oxygen deficiency.	Oxygen	126-132	insulin	Canis lupus familiaris	48-55
219125-4	1979	LDC and TRC in a dose-dependent fashion rapidly inhibited oxygen consumption and superoxide anion (O-2.)	Oxygen	58-64	tRNA-Cys (GCA) 24-1	Homo sapiens	8-11
219125-6	1979	Concentrations of 2 mM TRC or 16 mM LDC reduced O2 consumption and O-2.	Oxygen	48-50	tRNA-Cys (GCA) 24-1	Homo sapiens	23-26
20620956-2	2010	The SIRT1 deacetylase and the HIF-1alpha transcription factor act as redox and oxygen sensors, respectively.	Oxygen	79-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	30-40
20481447-3	2010	Cycloaddition reactivity is dependent upon the PR(3) employed, with PhP(catechyl) (catechyl = o-O(2)C(6)H(4)) providing the most rapid cycloadditions and optimal pyrrole yields.	Oxygen	94-97	N-acylsphingosine amidohydrolase 1	Homo sapiens	68-71
16660813-2	1979	The addition of 5% O(2) during the dark fixation period increased the total uptake of (14)CO(2) and the (14)C incorporation into aspartic acid.A study of the intramolecular distribution of radioactivity showed that 71 to 76% of the (14)C was located in the C(4) (beta-carboxyl) of malate and aspartate and the remainder in the C(1).	Oxygen	19-23	anthocyanin regulatory C1 protein	Zea mays	327-331
465593-4	1979	It was found that the most effective inhibitors of free oxygen activated species in the case of NADPH- and NADH-dependent LPO in the microsomal fractions of liver, brain and skeletal muscles are the superoxide (O ./2) anion radical inhibitors.	Oxygen	56-62	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
645923-8	1978	These data suggest that those conditions necessary for substantial myoglobin-facilitated diffusion of oxygen in the myocardium are not present in the isolated fluorocarbon-perfused dog heart.	Oxygen	102-108	myoglobin	Canis lupus familiaris	67-76
656704-1	1978	1 The acute effects of nicotine, tobacco smoke, and carbon monoxide on myocardial oxygen tension (MPo(2)) were estimated amperometrically in 33 anaesthetized open-chest cats with a glass-insulated 25 mum platinum cathode within a 22-gauge needle implanted in the left ventricular wall.2 MPo(2) was 1.6-60 mmHg (mean 23.5 mmHg) when arterial Po(2) was &gt;80 mmHg.	Oxygen	82-88	myeloperoxidase	Felis catus	98-101
20423081-0	2010	Evidence for copper-dioxygen reactivity during alpha-synuclein fibril formation.	Oxygen	20-28	synuclein alpha	Homo sapiens	47-62
639789-3	1978	It was found that maximal oxygen uptake correlated positively with %ST fibers and SDH activity in M. VL.	Oxygen	26-32	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	82-85
20423081-4	2010	Interestingly, we find that some population of Cu(II)-alpha-syn reduces to Cu(I)-alpha-syn in the absence of O(2).	Oxygen	109-113	synuclein alpha	Homo sapiens	54-63
210904-5	1978	Thus the electron transport from cytochrome b to a takes place in the outer region of inner mitochondrial membrane and the transmembranous location of cytochrome-oxidase facilitates the transfer of the electrons to oxygen.	Oxygen	215-221	cytochrome b	Sus scrofa	33-45
21386444-4	2010	The cells have chemo-mechanical interactions with each other and with the ECM, consume glucose and oxygen that are transported through the tumor, and create chemical by-products.	Oxygen	99-105	multimerin 1	Homo sapiens	74-77
20554-1	1977	The hydrogenase activity of the intact cells of a thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2 was determined using methylene blue; it was several times higher than the rate of hydrogen uptake in the presence of oxygene and carbon dioxide.	Oxygen	237-244	RBPJ pseudogene 3	Homo sapiens	116-119
20202476-3	2010	This toxin elicited a dose-dependent increase in reactive oxygen species and cell death that correlated with activation of ASK1 and the stress kinases p38 and JNK.	Oxygen	58-64	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	123-127
559282-7	1977	When infants with RDS were examined for oxygen toxicity and survival, red cell SOD levels were noted to decrease over 24 hr in four of five infants who died, three of whom developed bronchopulmonary dysplasia.	Oxygen	40-46	peripherin 2	Homo sapiens	18-21
20337491-2	2010	The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from alpha-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O(2) was found to be incorporated into the beta-carbon fragment as a carboxylic acid.	Oxygen	182-188	ATM serine/threonine kinase	Homo sapiens	192-195
831781-17	1977	The increase in the reduction level of cytochrome b on addition of HQNO in the presence of succinate and oxygen, either in the presence or absence of cyanide, does not parallel the inhibition of overall electron transfer.	Oxygen	105-111	mitochondrially encoded cytochrome b	Homo sapiens	39-51
20337491-2	2010	The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from alpha-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O(2) was found to be incorporated into the beta-carbon fragment as a carboxylic acid.	Oxygen	263-269	ATM serine/threonine kinase	Homo sapiens	192-195
20337491-2	2010	The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from alpha-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O(2) was found to be incorporated into the beta-carbon fragment as a carboxylic acid.	Oxygen	279-283	ATM serine/threonine kinase	Homo sapiens	192-195
9389-11	1976	Studies on the reoxidation of W(V) and reduced heme by O2 and by cytochrome c suggest that the cytochrome b5 of sulfite oxidase is the site of electron transfer to cytochrome c, whereas oxidase activity is the property of the molybdenum center.	Oxygen	55-57	sulfite oxidase	Rattus norvegicus	112-127
20085798-0	2010	Leptin: clue to poor appetite in oxygen-starved fish.	Oxygen	33-39	leptin a	Danio rerio	0-6
951157-0	1976	Letter: Reliability of transcutaneous PO2 with Roche Oxygen Monitor 5300 at 44 C in newborn infants with RDS.	Oxygen	53-59	peripherin 2	Homo sapiens	105-108
967792-0	1976	[Influence of methemoglobin in the measurement of oxygen consumption of the whole blood using an AO-oximeter].	Oxygen	50-56	hemoglobin subunit gamma 2	Homo sapiens	14-27
952695-8	1976	The degree of hypoxia after surgery correlated with vital capacity impairment and the improvement of oxygen tension after analgesia correlated with RRF after methadone 6 mg.	Oxygen	101-107	mitochondrial ribosome recycling factor	Homo sapiens	148-151
20130271-7	2010	Accumulation of HBEGF at reduced oxygen was blocked only by a combination of U0126, SB203580, and SP600125.	Oxygen	33-39	heparin binding EGF like growth factor	Homo sapiens	16-21
178656-3	1976	In soluble form, Center S-3 becomes extremely labile towards oxygen or ferricyanide plus phenazine methosulfate similar to reconstitutive activity of the dehydrogenase.	Oxygen	61-67	ribosomal protein S3	Homo sapiens	24-27
20412331-7	2010	RESULTS: Exposure of Kupffer cells isolated from control mice to 1% oxygen activated hypoxia-inducible factor-1alpha, and increased mRNA levels of platelet-derived growth factor-B, vascular endothelial growth factor, angiopoietin-1 and monocyte chemotactic protein-1.	Oxygen	68-74	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-116
816344-6	1976	Allele frequency shifts to 6-phosphogluconate dehydrogenase and phosphoglucomutase were observed in 5% oxygen, and a shift of alpha-glycerophosphate dehydrogenase allele frequencies occurred in 60% oxygen.	Oxygen	103-109	Phosphoglucose mutase 1	Drosophila melanogaster	64-82
20233924-5	2010	The anaerobic L-tartrate regulator TtdR or the oxygen sensors ArcB-ArcA and FNR did not have a major effect on dmlA expression.	Oxygen	47-53	hypothetical protein	Escherichia coli	62-66
942383-1	1976	The incubation of adrenal ferredoxin with various detergents in the presence of oxygen or ferricyanide leads to bleaching of the protein.	Oxygen	80-86	ferredoxin 1	Bos taurus	18-36
20359242-2	2010	The catalytic activity of the Au55(PPh3)12Cl6 nanoparticle in the presence of O2 stems from a combined effect of triphenylphosphine ligands and surface structure of the "magic-number" quasi-icosahedral Au55 core, which entails numerous ligand-encompassed triangle Au6 faces as the active sites.	Oxygen	78-80	protein phosphatase 4 catalytic subunit	Homo sapiens	35-39
13613-2	1976	Even though the oxygen affinity of hb-PLP in vitro was reduced when compared to the affinity of hb-W significant differences in vivo were lacking.	Oxygen	16-22	proteolipid protein 1	Homo sapiens	38-41
20376003-8	2010	The ability of FTO to distinguish 3-meT or 3-meU from other nucleotides is conferred by its hydrogen-bonding interaction with the two carbonyl oxygen atoms in 3-meT or 3-meU.	Oxygen	143-149	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	15-18
241510-1	1975	We report here the development of a new method that allows continuous determination of the oxygen dissociation curve for microsamples (600 mul) of whole blood under conditions of pH, pCO2, methemoglobin concentration, and 2,3-diphosphoglycerate content closely approaching those found in the circulatory system.	Oxygen	91-97	hemoglobin subunit gamma 2	Homo sapiens	189-202
20428232-8	2010	In the case of CXCL14(-/-)A(y) mice, oxygen consumption was increased compared to CXCL14(+/-)A(y) mice, in addition to the reduced food intake.	Oxygen	37-43	chemokine (C-X-C motif) ligand 14	Mus musculus	15-21
170855-3	1975	The subsequent addition of catalase (but not of superoxide dismutase) resulted in a substantial release of oxygen, indicating that H(2)O(2) was accumulating in the media.	Oxygen	107-113	AT695_RS10915	Staphylococcus aureus	27-35
19650690-6	2010	However, the mechanisms of iron homeostasis also are regulated by oxygen availability, with alterations in both hepcidin and IRP activity.	Oxygen	66-72	hepcidin antimicrobial peptide	Homo sapiens	112-120
163828-1	1975	Phenylhydrazine reacts with adult oxy- or methemoglobin in the presence of molecular oxygen to generate O2-.	Oxygen	104-106	hemoglobin subunit gamma 2	Homo sapiens	42-55
19650690-9	2010	In addition, HIF-2alpha translation is controlled by IRP activity, providing another level of interdependence between iron and oxygen homeostasis.	Oxygen	127-133	endothelial PAS domain protein 1	Homo sapiens	13-23
20083085-0	2010	Conversion of the g=4.1 EPR signal to the multiline conformation during the S(2) to S(3) transition of the oxygen evolving complex of Photosystem II.	Oxygen	107-113	protein phosphatase 2 regulatory subunit B''gamma	Homo sapiens	18-23
234308-0	1975	Assay of L-tyrosine in serum by amperometric measurement of tyrosinase-catalyzed oxygen consumption.	Oxygen	81-87	tyrosinase	Homo sapiens	60-70
234308-1	1975	A new enzymatic method for rapid direct measurement of serum tyrosine is described, based on the amperometric measurement of the rate of oxygen consumption when tyrosine is oxidized in the presence of the enzyme tyrosinase in a phosphate buffer (0.1 mol/liter, pH 7.4).	Oxygen	137-143	tyrosinase	Homo sapiens	212-222
20177991-5	2010	In contrast to cultures at 20% oxygen, where the central zones of the colonies underwent spontaneous differentiation, during exposure to 5% oxygen, the hESC colonies maintained a homogenous and flat morphology that was consistent with the presence of Oct4-positive undifferentiated phenotype.	Oxygen	140-146	POU class 5 homeobox 1	Homo sapiens	251-255
20005574-6	2010	The complex is of a 1:1 stoichiometry and can be readily oxidized electrochemically and chemically (by O(2)) to the putative alpha-syn-Fe(III) complex, with H(2)O(2) as a co-product.	Oxygen	103-107	synuclein alpha	Homo sapiens	125-134
4742453-1	1973	A new variant of haemoglobin A (Hb A) with a high affinity for oxygen has been found in an English family.	Oxygen	63-69	sodium voltage-gated channel alpha subunit 2	Homo sapiens	17-30
4742453-1	1973	A new variant of haemoglobin A (Hb A) with a high affinity for oxygen has been found in an English family.	Oxygen	63-69	sodium voltage-gated channel alpha subunit 2	Homo sapiens	32-36
758436-5	1979	Among surviving infants with RDS, fewer infants in the two to ten-day treated group required oxygen at FIO2 greater than 0.5 for more than 24 hours.	Oxygen	93-99	peripherin 2	Homo sapiens	29-32
20191646-0	2010	O2 activation and selective phenolate ortho hydroxylation by an unsymmetric dicopper mu-eta1:eta1-peroxido complex.	Oxygen	0-2	secreted phosphoprotein 1	Homo sapiens	88-92
4400984-0	1971	Effects of pure oxygen atmosphere in vivo on plasma lecithin-cholesterol acyltransferase reaction.	Oxygen	16-22	lecithin-cholesterol acyltransferase	Homo sapiens	52-88
20191646-0	2010	O2 activation and selective phenolate ortho hydroxylation by an unsymmetric dicopper mu-eta1:eta1-peroxido complex.	Oxygen	0-2	secreted phosphoprotein 1	Homo sapiens	93-97
545945-3	1979	An original method of determination the oxygen dissociation curve of HbO2 was employed enabling an exact calculation of the P50 value of the hemolysates by the method of least squares.	Oxygen	40-46	activating signal cointegrator 1 complex subunit 1	Homo sapiens	124-127
5091162-2	1971	Oxygen consumption in vitro and persistence in the general circulation of rabbit erythrocytes treated with the cholinesterase inhibitor paraoxon were determined.2.	Oxygen	0-6	cholinesterase	Oryctolagus cuniculus	111-125
545945-4	1979	Analysis of statistically verified results reveals that zinc ions increase the oxygen affinity of hemoglobin bringing about a leftward shift of the HbO2 dissociation curve (by 3.85 mm Hg for P50) the level of 2,3-DPG remaining constant in the red cells incubated with ZnSO4.	Oxygen	79-85	activating signal cointegrator 1 complex subunit 1	Homo sapiens	191-194
711860-4	1978	Plasma renin activity increased from 2.3+/-0.4 to 4.9+/-0.8 ng/ml per h during 8% oxygen breathing, and from 2.8+/-0.4 to 8.4+/-1.8 ng/ml per h during 5% oxygen breathing.	Oxygen	82-88	renin	Canis lupus familiaris	7-12
711860-4	1978	Plasma renin activity increased from 2.3+/-0.4 to 4.9+/-0.8 ng/ml per h during 8% oxygen breathing, and from 2.8+/-0.4 to 8.4+/-1.8 ng/ml per h during 5% oxygen breathing.	Oxygen	154-160	renin	Canis lupus familiaris	7-12
5149242-0	1971	[Effect of complex spa therapy on myocardial oxygen consumption in patients with coronary disease].	Oxygen	45-51	surfactant protein A2	Homo sapiens	19-22
5604707-0	1967	[On the effect of high oxygen and air pressure in experimental hypoxia evoked by acute poisoning due to methemoglobin-forming agents].	Oxygen	23-29	hemoglobin subunit gamma 2	Homo sapiens	104-117
20186336-5	2010	We show that loss of DJ-1 caused impaired mitochondrial respiration, increased intramitochondrial reactive oxygen species, reduced mitochondrial membrane potential and characteristic alterations of mitochondrial shape as shown by quantitative morphology.	Oxygen	107-113	Parkinsonism associated deglycase	Homo sapiens	21-25
4973018-0	1967	[Chemolithotrophic growth of Hydrogenomonas H16 in a chemostat with electrolytic production of oxygen and hydrogen].	Oxygen	95-101	H1.6 linker histone, cluster member	Homo sapiens	44-47
283392-0	1978	Phosphate (oxygen)-water exchange reaction catalyzed by human prostatic acid phosphatase.	Oxygen	11-17	acid phosphatase 3	Homo sapiens	62-88
283392-2	1978	Studies conducted with human prostatic acid phosphatase by two independent methods have established that, despite earlier reports to the contrary, the enzyme catalyzes an exchange reaction between oxygen atoms of phosphate ion and of water.	Oxygen	197-203	acid phosphatase 3	Homo sapiens	29-55
651894-5	1978	Children with a higher relative oxygen capacity (56 ml O2/kg) run faster and revealed lower heart rates than children with less relative oxygen capacity (39.8 ml O2/kg).	Oxygen	32-38	immunoglobulin kappa variable 1D-39	Homo sapiens	55-60
20007325-7	2010	This site was coordinated by the acidic side chain of Glu(173) and carbonyl oxygen of Thr(168), which correspond, respectively, to Glu(140) and Thr(135) of human H chain ferritin according to their sequences.	Oxygen	76-82	ferritin-1, chloroplastic	Glycine max	170-178
5952851-0	1966	Rapid oxygen change as possible etiology of RLF and autism.	Oxygen	6-12	RLF zinc finger	Homo sapiens	44-47
22547-6	1978	The kinetics of the ligation of O2 and CO were used to characterize the affinity states of the valence-hybrid and its parent methemoglobin.	Oxygen	32-34	hemoglobin subunit gamma 2	Homo sapiens	125-138
20238004-0	2010	Increased expression of TGF-beta1 and Smad 4 on oxygen-induced retinopathy in neonatal mice.	Oxygen	48-54	SMAD family member 4	Mus musculus	38-44
4379842-0	1965	[Methemoglobin formation by sulfonamides in a system containing liver homogenates, erythrocytes, NADPH and oxygen].	Oxygen	107-113	hemoglobin subunit gamma 2	Homo sapiens	1-14
20238004-7	2010	In this study, we used the model of oxygen-induced retinopathy in neonatal mice to investigate the expression of TGF-beta1 and Smad 4 mRNA in the retina, to explore their role in the development of retinal neovascularization.	Oxygen	36-42	SMAD family member 4	Mus musculus	127-133
342922-8	1978	Keeping ambient oxygen concentrations constant, an increase in arterial oxygen tension was measured in almost all patients surviving on N-CPAP and was initially even seen in those who later died, so that the ambient oxygen concentration could eventually be decreased.	Oxygen	72-78	centromere protein J	Homo sapiens	138-142
19944667-2	2010	The flavin-oxygen adduct can be the C4a-peroxide anion, in which case it reacts as a nucleophile.	Oxygen	11-17	complement C4A (Rodgers blood group)	Homo sapiens	36-39
342922-8	1978	Keeping ambient oxygen concentrations constant, an increase in arterial oxygen tension was measured in almost all patients surviving on N-CPAP and was initially even seen in those who later died, so that the ambient oxygen concentration could eventually be decreased.	Oxygen	72-78	centromere protein J	Homo sapiens	138-142
14185319-1	1964	Gamma-ray irradiation of polypeptides as highly dispersed fluffs under oxygen leads to chemical degradation of the peptide bond with the remarkably high oxygen consumption of about one molecule per 2 ev of absorbed energy.	Oxygen	71-77	period circadian regulator 2	Homo sapiens	194-199
14185319-1	1964	Gamma-ray irradiation of polypeptides as highly dispersed fluffs under oxygen leads to chemical degradation of the peptide bond with the remarkably high oxygen consumption of about one molecule per 2 ev of absorbed energy.	Oxygen	153-159	period circadian regulator 2	Homo sapiens	194-199
20193091-10	2010	Supplementation of cadmium chloride during differentiation culture at 5% O(2) drastically reduced the up-regulation of type II collagen and the down-regulation of MMP-1 mRNA.	Oxygen	73-77	matrix metallopeptidase 1	Homo sapiens	163-168
21302556-5	2010	Laboratory studies using the pulsed laser photolysis/laser induced fluorescence and flow tube/mass spectrometer techniques were used to measure the following rate coefficients: k (Mg+ + CO2 (+ CO2) --&gt; Mg+ x CO2, 190-403 K) = (5.3 +/- 0.7) x 10(-29) (T/300 K)(-1.86 +/- 0.03) cm6 molecule --&gt; 2 s(-1); k(Mg+ x CO2 + O2 --&gt; MgO2(+) + CO2, 297 K) = (2.2 +/- 0.8) x 10(-11) cm3 molecule(-1) s(-1); k(MgO2(+) + O --&gt; MgO(+) + O2, 297 K) = (6.5 +/- 1.8) x 10(-10) cm3 molecule(-1) s(-1); and k(MgO(+) + O --&gt; Mg(+) + O2, 297 K) = (5.9 +/- 2.4) x 10(-10) cm3 molecule(-1) s(-1).	Oxygen	187-189	complement C2	Homo sapiens	193-196
13887040-0	1962	[Disorders of oxygen transport in the lung in lung fibroses with special reference to the O-2 diffusion capacity].	Oxygen	14-20	immunoglobulin kappa variable 1D-39	Homo sapiens	90-93
598384-0	1977	Heterogeneity in the kinetics of oxygen binding to partially reduced human methemoglobin.	Oxygen	33-39	hemoglobin subunit gamma 2	Homo sapiens	75-88
20414335-1	2010	Erythropoietin (Epo) and vascular growth factor (VEGF) are known to be involved in the regulation of cellular activity when oxygen transport is reduced as in anaemia or hypoxic conditions.	Oxygen	124-130	erythropoietin	Mus musculus	16-19
24868-2	1977	Under physiological conditions (41 C, pH 7.5, PCO2 approximately 35 Torr) the oxygen half saturation pressure P50 are 50 Torr for the chickens, 38 Torr for the pigeon, 43 Torr for the Japanese quail and 44 Torr for the sparrow.	Oxygen	78-84	dynactin subunit 2	Gallus gallus	110-113
19691335-4	2009	The energetics and structure of the different adducts have been calculated ab initio at the MP2(full) level, showing that the M(+)-molecule interaction takes place through the carbonyl oxygen atom, as an example of a nontypical covalent chemical bond.	Oxygen	185-191	tryptase pseudogene 1	Homo sapiens	92-95
915164-0	1977	Biosynthetic origin of the oxygen atoms in the C15 macrolide antibiotic brefeldin A1.	Oxygen	27-33	placenta associated 8	Homo sapiens	47-50
19868522-1	1921	In the occasional cases of pneumonia which show a decrease in the oxygen capacity of the blood, the decrease is probably due to a formation of methemoglobin.	Oxygen	66-72	hemoglobin subunit gamma 2	Homo sapiens	143-156
18815084-1	2009	BACKGROUND: The angiogenic potential of vascular endothelial growth factor (VEGF) and its oxygen pressure-dependent regulation suggest a strong connection between this growth factor and the "delay phenomenon".	Oxygen	90-96	vascular endothelial growth factor A	Rattus norvegicus	40-74
33627050-2	2021	The increase of Abeta stimulates all kinds of active oxygen and causes oxidative stress and apoptosis.	Oxygen	53-59	amyloid beta precursor protein	Rattus norvegicus	16-21
33895119-4	2021	Herein, we investigated the impact of genistein, biochanin A, formonentin and kaempferol on the expression of the CYP24A1 gene induced by calcitriol in hepatocellular cancer cells Huh7 under normoxia (21%O2) or hypoxia (1%O2).	Oxygen	204-206	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-121
33895119-4	2021	Herein, we investigated the impact of genistein, biochanin A, formonentin and kaempferol on the expression of the CYP24A1 gene induced by calcitriol in hepatocellular cancer cells Huh7 under normoxia (21%O2) or hypoxia (1%O2).	Oxygen	222-224	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-121
33985712-7	2021	GA3 always isomerized from the gamma-lactone ring due to the lowest bond energy between the oxygen terminus of the gamma-lactone ring and A ring.	Oxygen	92-98	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	0-3
22080-1	1977	A study of the near-infrared absorption spectra of three oxygen compounds of membrane-bound cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) shows that the formation of compound A (oxycytochrome oxidase) causes no significant infrared absorbance changes at -103 degrees.	Oxygen	57-63	thioredoxin reductase 1	Homo sapiens	137-151
330410-1	1977	Two extremely oxygen-sensitive strains of Clostridium sp., designated Clostridium E and P, were obtained from digestive microflora of conventional mice and found to constitute a barrier against Shigella flexneri SF-2 when associated in vivo with Escherichia coli K-12.	Oxygen	14-20	serine and arginine-rich splicing factor 1	Mus musculus	212-216
896486-1	1977	Extensive incorporation of oxygen-18 at position O4 of the pyrimidine nucleus results from exchange between H218O and nucleosides or bases in 1N HC1 at 100 degrees.	Oxygen	27-33	CYCS pseudogene 39	Homo sapiens	145-148
33632987-11	2021	The expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin were increased after hES-MSCs were incubated for 48 h in 2% O2 condition.	Oxygen	120-122	insulin like growth factor binding protein 6	Homo sapiens	28-35
33632987-12	2021	Conclusions: The hES-MSCs viability and expressions of PDGF-BB, IGFBP-6, VEGF-A, and angiogenin increased after 48 h incubation in 2% O2 condition.	Oxygen	134-136	insulin like growth factor binding protein 6	Homo sapiens	64-71
864782-3	1977	Therefore, NO affects the oxygen transport function of hemoglobin, decreasing the oxygen supply to peripheral tissues, because of (1) simple diminution of the available hemoglobin by the tightly bound NO, (2) the high affinity of hemoglobin for oxygen, and (3) the inevitable formation of methemoglobin.	Oxygen	26-32	hemoglobin subunit gamma 2	Homo sapiens	289-302
18815084-1	2009	BACKGROUND: The angiogenic potential of vascular endothelial growth factor (VEGF) and its oxygen pressure-dependent regulation suggest a strong connection between this growth factor and the "delay phenomenon".	Oxygen	90-96	vascular endothelial growth factor A	Rattus norvegicus	76-80
18815084-1	2009	BACKGROUND: The angiogenic potential of vascular endothelial growth factor (VEGF) and its oxygen pressure-dependent regulation suggest a strong connection between this growth factor and the "delay phenomenon".	Oxygen	90-96	myotrophin	Rattus norvegicus	61-74
856576-6	1977	In contrast, the reconstituted benzo[a]pyrene hydroxylase system, with purified cytochrome P-448 from 3-methylcholanthrene-induced rats, exhibited a considerably higher sensitivity towards CO (CO/O2 ratio approximately 1), well within the range for mixed-function oxidase reactions.	Oxygen	196-198	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-96
19745171-8	2009	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	solute carrier family 8 member A3	Rattus norvegicus	157-161
602753-1	1977	A significant rise in the frequency of neonatal pulmonary haemorrhage was observed in the year when intensive oxygen therapy by CPAP and IPPV ventilation was started.	Oxygen	110-116	centromere protein J	Homo sapiens	128-132
34042234-0	2021	CaMn3IVO4 Cubane Models of the Oxygen Evolving Complex: Spin Ground States S < 9/2 and the Effect of Oxo Protonation.	Oxygen	31-37	spindlin 1	Homo sapiens	56-60
34042234-6	2021	Our studies complement the observation that the interconversion between the low spin and high spin forms of the S2 state is pH dependent, suggesting that (de)protonation of bridging or terminal oxygen atoms in the OEC may be connected to spin state changes.	Oxygen	194-200	spindlin 1	Homo sapiens	80-84
34042234-6	2021	Our studies complement the observation that the interconversion between the low spin and high spin forms of the S2 state is pH dependent, suggesting that (de)protonation of bridging or terminal oxygen atoms in the OEC may be connected to spin state changes.	Oxygen	194-200	spindlin 1	Homo sapiens	94-98
34042234-6	2021	Our studies complement the observation that the interconversion between the low spin and high spin forms of the S2 state is pH dependent, suggesting that (de)protonation of bridging or terminal oxygen atoms in the OEC may be connected to spin state changes.	Oxygen	194-200	spindlin 1	Homo sapiens	94-98
19805032-4	2009	Here, we report experimental evidence for a key ferryl intermediate of hIDO that supports a mechanism in which the 2 atoms of dioxygen are inserted into the substrate via a consecutive 2-step reaction.	Oxygen	126-134	indoleamine 2,3-dioxygenase 1	Homo sapiens	71-75
34038190-3	2021	Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-protein co-activator that induces the transcription of RNA polymerase II by DNA transcription factors.	Oxygen	45-51	mediator complex subunit 19	Homo sapiens	0-27
34038190-3	2021	Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-protein co-activator that induces the transcription of RNA polymerase II by DNA transcription factors.	Oxygen	45-51	mediator complex subunit 19	Homo sapiens	58-98
198179-7	1977	A certain role in disturbances of oxidative processes may have been played by the decreased concentration of myoglobin, an important myocardial reservoir of oxygen.	Oxygen	157-163	myoglobin	Canis lupus familiaris	109-118
19617311-8	2009	Instead, the number of type II cells progressively declined in 60-100% oxygen, whereas levels of T1alpha, a protein expressed by type I cells, were comparably increased in mice exposed to 40-100% oxygen.	Oxygen	196-202	podoplanin	Mus musculus	97-104
12172-10	1976	Relative to Hb A, both Hb Providence Asn and Hb Providence Asp show decreased oxygen affinities at neutral pH in the absence of cofactors.	Oxygen	78-84	sodium voltage-gated channel alpha subunit 2	Homo sapiens	12-16
12172-11	1976	This suggests that in Hb A the binding of anionic cofactors directly influences the oxygen affinity by neutralizing the charged groups of the diphosphoglycerate binding site and thus stabilizing the low affinity (T) conformation.	Oxygen	84-90	sodium voltage-gated channel alpha subunit 2	Homo sapiens	22-26
12172-12	1976	From pH 6 to 9 in the presence of 1 M NaCl, where all the charged groups may be masked, the oxygen-binding properties of Hb A and the Hb Providence mutants are identical.	Oxygen	92-98	sodium voltage-gated channel alpha subunit 2	Homo sapiens	121-125
34027895-2	2021	Oxygen tension is an environmental cue that distinguishes peripheral tissues from the circulation, and here, we demonstrate that differentiation of human CD8+ T cells in the presence of hypoxia and TGF-beta1 led to the development of a TRM phenotype, characterized by a greater than 5-fold increase in CD69+CD103+ cells expressing human TRM hallmarks and enrichment for endogenous human TRM gene signatures, including increased adhesion molecule expression and decreased expression of genes involved in recirculation.	Oxygen	0-6	CD8a molecule	Homo sapiens	154-157
34016964-8	2021	Macrophage-derived exosomes, upregulated miR-503-3p or inhibited DACT2 promoted malignant behaviors of BC cells, glucose intake, and activity of the Wnt/beta-catenin signaling pathway, while repressed oxygen consumption rate and ATP level in BC cells.	Oxygen	201-207	dishevelled binding antagonist of beta catenin 2	Homo sapiens	65-70
34008688-5	2021	Upon initial dissociation of the host-guest interactions and hence Au NVs by cancer-specific reactive oxygen species (ROS), GOx is released to consume glucose and oxygen, generate H2O2 and induce the hypoxic TME, which act as the two keys for triggering burst payload release and promoter activation, thus allowing synergistic starvation and gene therapy of cancer.	Oxygen	102-108	hydroxyacid oxidase 1	Homo sapiens	124-127
1032664-2	1976	A comparison of the UV-visible and fluorescence spectral characteristics of anhydrotetracycline and its metal-ion complexes with a number of modified anhydrotetracyclines in the presence of metal ions suggested that the C-11 oxygen was involved in metal-ion binding.	Oxygen	225-231	RNA polymerase III subunit K	Homo sapiens	220-224
19617311-9	2009	Thickened bundles of elastin fibers were also detected in alveolar walls of mice exposed to &gt; or = 60% oxygen.	Oxygen	106-112	elastin	Mus musculus	21-28
975043-4	1976	The hydrogen atom on C-3 points directly toward the oxygen atom of another molecule.	Oxygen	52-58	complement C3	Homo sapiens	21-24
19596041-3	2009	In this study, hypoxia (1% Oxygen) induced a decrease in both global acetylated histone H4 (AcH4) and c-Myc in human lung carcinoma A549 cells and in human bronchial epithelial Beas-2B cells, The decline was more striking in A549 cells compared to Beas2-B cells, when cells were exposed to hypoxic stress for 24 h. Further studies showed that these alterations of global AcH4 can be attributed to the decrease in c-Myc protein levels.	Oxygen	27-33	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
778498-1	1976	Therapeutic use of helium-oxygen mixture in continuous positive airway pressure (He-CPAP) was employed for early weaning from mechanical ventilation of 11 infants who underwent cardiac surgery from August, 1974, to April, 1975.	Oxygen	26-32	centromere protein J	Homo sapiens	84-88
778498-3	1976	Hg elevation of PaO2 was usually observed and respiratory distress was reduced, as compared to results obtained with nitrogen-oxygen CPAP.	Oxygen	126-132	centromere protein J	Homo sapiens	133-137
33990706-7	2021	Comparative genomics analysis identifies that the nif genes found in free-living Bradyrhizobium are located on a unique genomic island of ~50 kb equipped with genes potentially involved in coping with oxygen tension.	Oxygen	201-207	S100 calcium binding protein A9	Homo sapiens	50-53
34054553-11	2021	However, inflammation-associated genes induced by TNF/IL17 were attenuated at low oxygen concentration.	Oxygen	82-88	interleukin 17A	Homo sapiens	54-58
19596041-3	2009	In this study, hypoxia (1% Oxygen) induced a decrease in both global acetylated histone H4 (AcH4) and c-Myc in human lung carcinoma A549 cells and in human bronchial epithelial Beas-2B cells, The decline was more striking in A549 cells compared to Beas2-B cells, when cells were exposed to hypoxic stress for 24 h. Further studies showed that these alterations of global AcH4 can be attributed to the decrease in c-Myc protein levels.	Oxygen	27-33	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	413-418
19877889-5	2009	Interestingly, when rh-endostatin treatment was discontinued, there was an elevation in the diffusion of oxygen and tetramethylrhodamine isothiocyanate-dextran in both tumor classes, which was detected by hypoxyprobe (pimonidazole) and fluorescence microscopy.	Oxygen	105-111	collagen type XVIII alpha 1 chain	Homo sapiens	23-33
33979328-5	2021	Cool temperatures induce stearoyl-CoA desaturase-1 (SCD1) expression and monounsaturated lipid levels in cultured adipocytes and distal bone marrow adipose tissues (BMATs), and SCD1 activity is required for acquisition of maximal oxygen consumption at 31 C.	Oxygen	230-236	stearoyl-CoA desaturase	Homo sapiens	177-181
33969704-1	2021	Myoglobin (Mb) is a regulator of O2 bioavailability in type I muscle and heart, at least when tissue O2 levels drop.	Oxygen	33-35	myoglobin	Mus musculus	0-9
33969704-1	2021	Myoglobin (Mb) is a regulator of O2 bioavailability in type I muscle and heart, at least when tissue O2 levels drop.	Oxygen	101-103	myoglobin	Mus musculus	0-9
809633-1	1975	The effects of oxygen on production of pentane and compounds absorbing at 234 nm and 285 nm by soybean lipoxygenase isozymes I and II were examined in a model system.	Oxygen	15-21	linoleate 9S-lipoxygenase-4	Glycine max	103-115
19443721-0	2009	Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy.	Oxygen	89-95	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-33
236-4	1975	The high-affinity sites show, in the case of the simple digests, a strong oxygen linkage which is lost in the forms digested with both carboxypeptidase A and B; this linkage may thus be correlated to the presence of conformational changes.	Oxygen	74-80	carboxypeptidase B1	Homo sapiens	135-159
239446-3	1975	Colicin activity was influenced by temperature, pH and oxygen tension as well as by the availability of certain nutrients and the presence of trypsin.	Oxygen	55-61	colicin	Escherichia coli	0-7
33969705-1	2021	Myoglobin (Mb) regulates O2 bioavailability in muscle and heart as partial pressure of O2 (pO2) drops with increased tissue workload.	Oxygen	25-27	myoglobin	Mus musculus	0-9
33969705-1	2021	Myoglobin (Mb) regulates O2 bioavailability in muscle and heart as partial pressure of O2 (pO2) drops with increased tissue workload.	Oxygen	87-89	myoglobin	Mus musculus	0-9
33963958-0	2021	Expression of CD44 variant 9 induces chemoresistance of gastric cancer by controlling intracellular reactive oxygen spices accumulation.	Oxygen	109-115	CD44 molecule (Indian blood group)	Homo sapiens	14-18
19443721-0	2009	Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy.	Oxygen	89-95	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	35-40
19443721-3	2009	METHODS: The temporal expression of PAI-1 was examined by real-time PCR, Western blot analysis, and immunohistochemistry in retinal tissues from mice with oxygen-induced retinopathy.	Oxygen	155-161	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	36-41
234362-1	1975	Some changes with exposure to 1 ATM oxygen.	Oxygen	36-42	ATM serine/threonine kinase	Rattus norvegicus	32-35
19443721-6	2009	RESULTS: PAI-1 expression was upregulated in the retinas of mice with oxygen-induced retinopathy, which coincided with a significant increase in the expression of vitronectin in the retina of the experimental mice.	Oxygen	70-76	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	9-14
33835130-1	2021	Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings, including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic pain, and epilepsy.	Oxygen	104-110	pannexin 1	Homo sapiens	0-10
19765320-1	2009	BACKGROUND: Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs).	Oxygen	115-121	early growth response 1	Homo sapiens	49-72
33835130-1	2021	Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings, including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic pain, and epilepsy.	Oxygen	104-110	pannexin 1	Homo sapiens	12-17
33837999-0	2021	A Generalized Method for High-Speed Fluorination of Metal Oxides by Spark Plasma Sintering Yields Ta3 O7 F and TaO2 F with High Photocatalytic Activity for Oxygen Evolution from Water.	Oxygen	156-162	TAO kinase 2	Homo sapiens	111-115
33837999-7	2021	iv) SPS processing changes the catalytic properties: while conventionally prepared Ta3 O7 F and TaO2 F show little catalytic activity, SPS-prepared Ta3 O7 F and TaO2 F exhibit high activity for photocatalytic oxygen evolution, reaching photoconversion efficiencies up to 24.7% and applied bias to photoconversion values of 0.86%.	Oxygen	209-215	TAO kinase 2	Homo sapiens	161-165
33210737-4	2021	Paraoxonase-2 (PON2) is an intracellular enzyme exerting a protective role against production of reactive oxygen species within mitochondrial respiratory chain.	Oxygen	106-112	paraoxonase 2	Homo sapiens	0-13
1105228-19	1975	The changes of artero-mixed venous oxygen saturation difference which were calculated at 100 mmHg of PaO2 and 40mmHg of mixed venous PO2 were in a linear fashion with those of P50.	Oxygen	35-41	activating signal cointegrator 1 complex subunit 1	Homo sapiens	176-179
168750-9	1975	The reconstituted enzyme system containing purified cytochrome P-450, purified NADPH-cytochrome P-450 reductase, and phosphatidylcholine retains the ability to catalyze the hydroxylation of drugs, fatty acids, hydrocarbons, and aniline in the presence of NADPH and molecular oxygen.	Oxygen	275-281	cytochrome p450 oxidoreductase	Rattus norvegicus	79-111
1191177-9	1975	R-2 reacts 16 times more readily that R-1 with oxygen under formation of single-strand breaks in the DNA.	Oxygen	47-53	CD1e molecule	Homo sapiens	0-3
33210737-4	2021	Paraoxonase-2 (PON2) is an intracellular enzyme exerting a protective role against production of reactive oxygen species within mitochondrial respiratory chain.	Oxygen	106-112	paraoxonase 2	Homo sapiens	15-19
19765320-1	2009	BACKGROUND: Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs).	Oxygen	115-121	early growth response 1	Homo sapiens	74-79
4426396-0	1974	Abnormal functional properties of Hb Hope alpha C2A beta2 (H14) Gly-Asp: a low oxygen affinity hemoglobin with decreased DPG effect.	Oxygen	79-85	H1.4 linker histone, cluster member	Homo sapiens	59-62
19705812-1	2009	High concentration-dependent halogen bonding, a specific solvent effect between carbon tetrabromide and oxygen-containing organic solvents, including methanol, ethanol, acetone, dioxane, diethyl ether, and tetrahydrofuran, was found to coexist with the general solvent effect when CBr4 was over 7.8 x 10(-3) M approximately 1.6 x 10(-2) M critical concentration range.	Oxygen	104-110	carbonyl reductase 4	Homo sapiens	281-285
4825370-0	1974	The determination of O-2-dissociation curves in hemoglobin solutions with a liquid fluorocarbon O2-transport system.	Oxygen	96-98	immunoglobulin kappa variable 1D-39	Homo sapiens	21-24
33913581-8	2021	Normoxic A2B R activation triggered an HIF-1alpha-associated cell-protective metabolic switch and reduced oxygen consumption.	Oxygen	106-112	adenosine A2b receptor	Mus musculus	9-14
19705812-7	2009	The MP2 method was also employed to calculate the formation of the sigma-hole (sigma(h)) bonding complexes between carbon tetrabromide and oxygen-containing organic solvents.	Oxygen	139-145	tryptase pseudogene 1	Homo sapiens	4-7
33932953-14	2021	In VSMCs, LRRC8C knockdown (siRNA) recapitulated the effects of siLRRC8A, inhibiting TNFalpha-induced extracellular and endosomal O2  - production, receptor endocytosis, NF-kappaB activation, and proliferation.	Oxygen	130-135	leucine rich repeat containing 8 VRAC subunit C	Homo sapiens	10-16
19753307-7	2009	Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.	Oxygen	82-88	uncoupling protein 1	Homo sapiens	66-70
30335718-0	2021	Influence of the ACTN3 Genotype and the Exercise Intensity on the Respiratory Exchange Ratio and Excess Oxygen Consumption After Exercise.	Oxygen	104-110	actinin alpha 3	Homo sapiens	17-22
30335718-2	2021	Influence of the ACTN3 genotype and the exercise intensity on the respiratory exchange ratio and excess oxygen consumption after exercise.	Oxygen	104-110	actinin alpha 3	Homo sapiens	17-22
4802071-2	1973	Oxygen partial pressure and methemoglobin formation during dialysis of preserved blood in the cellophane membrane artificial kidney with PD375 and oxygen insufflation and with added hydrogen peroxide].	Oxygen	147-153	hemoglobin subunit gamma 2	Homo sapiens	28-41
4515930-3	1973	The kinetic results show that the equilibrium affinity difference results both from a much larger oxygen dissocation rate constant in beta(Kansas) (k = 37 sec(-1) and 18 sec(-1) for beta(Kansas) and beta(A), respectively) and from a lower association reaction rate, The properties of the alpha chains from hemoglobins A and Kansas appear to be identical, as expected.	Oxygen	98-104	secretory blood group 1, pseudogene	Homo sapiens	155-161
19694805-4	2009	Using the directed evolution approach, one DAAO mutant was identified that has increased activity at low O2 and D-Ala concentrations and a 10-fold lower K(m) for O2.	Oxygen	105-107	D-amino acid oxidase	Homo sapiens	43-47
4515930-3	1973	The kinetic results show that the equilibrium affinity difference results both from a much larger oxygen dissocation rate constant in beta(Kansas) (k = 37 sec(-1) and 18 sec(-1) for beta(Kansas) and beta(A), respectively) and from a lower association reaction rate, The properties of the alpha chains from hemoglobins A and Kansas appear to be identical, as expected.	Oxygen	98-104	secretory blood group 1, pseudogene	Homo sapiens	170-176
33760153-13	2021	In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway.	Oxygen	26-32	fms related receptor tyrosine kinase 4	Homo sapiens	218-225
19694805-4	2009	Using the directed evolution approach, one DAAO mutant was identified that has increased activity at low O2 and D-Ala concentrations and a 10-fold lower K(m) for O2.	Oxygen	162-164	D-amino acid oxidase	Homo sapiens	43-47
33930202-16	2021	Our results showed that the inhibitory effect of mTOR inhibitor (rapamycin) on reactive oxygen species production during NLRP3 inflammasome activation could bring about behavioral alterations in anxiety and depression.	Oxygen	88-94	mechanistic target of rapamycin kinase	Rattus norvegicus	49-53
19365612-10	2009	These results demonstrated that PEG 10 wt% modified PLA HbP with suitable size, surface charge, and surface hydrophilicity, has a promising potential as long-circulating oxygen carriers with desirable biocompatibility and biofunctionality.	Oxygen	170-176	paternally expressed 10	Mus musculus	32-38
33908151-6	2021	For a comprehensive understanding, the spectroscopic  findings  will  be  supplemented  by  results  of  the dynamics  of  O2   activation  obtained  from  Temporal  Analysis  of Products  (TAP).	Oxygen	123-125	nuclear RNA export factor 1	Homo sapiens	190-193
5390262-0	1969	[Fine variation of the oxygen isotopes 32-O2 and 34-O2 in human expired air].	Oxygen	23-29	immunoglobulin kappa variable 1D-39	Homo sapiens	42-51
5658592-3	1968	In contrast, a correlation between red cell mass and arterial O(2) tension was found only over the lower half of the range of O(2) tensions where Sa(O2) was also decreased (r = - 0.7731, P &lt; 0.005).	Oxygen	62-66	immunoglobulin kappa variable 1D-39	Homo sapiens	146-151
19636091-1	2009	We report a reliable method for preparing a pure Ir single-atom tip by thermal treatment in oxygen.	Oxygen	92-98	TOR signaling pathway regulator	Homo sapiens	64-67
5690111-8	1968	Activation of kallikrein by neonatal granulocytes was dependent on cell concentration and required oxygen tensions comparable to those in the neonate but above the range in the fetus.	Oxygen	99-105	kallikrein related peptidase 4	Homo sapiens	14-24
4293080-7	1967	The data were interpreted as indicating that cytochrome c peroxidase was an oxygen-inducible enzyme, and that there was a developmental relationship between enzyme-reactive membranes of mitochondria and cytoplasm during the period of respiratory adaptation.	Oxygen	76-82	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	45-68
6020561-3	1967	The apparent K(m) for oxygen for thiosulfate oxidation by A-50 was about 223 mum, but, for lactate oxidation by A-50 or thiosulfate oxidation by C-3, the apparent K(m) for oxygen was below 2 mm.	Oxygen	172-178	complement C3	Homo sapiens	145-148
33909984-0	2021	Succinate Dehydrogenase (SDH)-subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.	Oxygen	57-63	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
33909984-0	2021	Succinate Dehydrogenase (SDH)-subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.	Oxygen	57-63	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
33909984-3	2021	Using a recently established animal model of pulmonary emphysema-driven skeletal muscle dysfunction, we found downregulation of succinate dehydrogenase (SDH) subunit C in association with lower oxygen consumption and fatigue-tolerance in locomotor muscles.	Oxygen	194-200	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	128-151
33909984-3	2021	Using a recently established animal model of pulmonary emphysema-driven skeletal muscle dysfunction, we found downregulation of succinate dehydrogenase (SDH) subunit C in association with lower oxygen consumption and fatigue-tolerance in locomotor muscles.	Oxygen	194-200	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	153-156
33909984-5	2021	Moreover, in-vivo gain of SDH function in emphysema animals muscles resulted in better oxygen consumption rate (OCR) and fatigue tolerance.	Oxygen	87-93	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	26-29
33919074-6	2021	The results of VPD540 dye and MTS assays showed a significant reduction in cell proliferation after FAM13A knockdown in A549 cells cultured under normal and hypoxia (1% O2) conditions (p < 0.05), while the effect of FAM13A downregulation on CORL-105 cells was observed after 96 h exposition to hypoxia.	Oxygen	169-171	family with sequence similarity 13 member A	Homo sapiens	100-106
33919074-8	2021	Silencing of FAM13A significantly suppressed migration of A549 and CORL-105 cells in both oxygen conditions, especially after 72 and 96 h (p < 0.001 in normoxia, p < 0.01 after hypoxia).	Oxygen	90-96	family with sequence similarity 13 member A	Homo sapiens	13-19
5879171-2	1965	10-Cyanosteroids</compound-id> with an oxygen at C-3.	Oxygen	39-45	complement C3	Homo sapiens	49-52
19636091-3	2009	We have shown that the Ir single-atom tip can be a good field ion emitter, capable of emitting a variety of gas ion beams, such as He+, H2+, N2+, and O2+, with high brightness and stability.	Oxygen	150-153	TOR signaling pathway regulator	Homo sapiens	38-41
19406099-5	2009	The quantum yield of oxygen evolution in leaves decreased from 0.109 (wild type) to 0.087 (ch1-3) and 0.081 (ch1-3lhcb5) O(2) (photon absorbed)(-1); we attribute this decrease to an excessive spillover from PSII to PSI, a limited PSII antenna, and increased light-independent thermal dissipation in PSII in the mutants.	Oxygen	21-27	Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein	Arabidopsis thaliana	91-96
14342540-0	1965	[KINETICS OF THE INDUCED BIOSYNTHESIS OF ISO-1-CYTOCHROME C AND ISO-2-CYTOCHROME C DURING ADAPTATION TO OXYGEN].	Oxygen	104-110	eukaryotic translation initiation factor 1	Homo sapiens	41-46
33866604-6	2022	When mitochondria respiration was assessed in PERK deficient DC there were increased dysfunctional mitochondria after RSV infection that resulted in reduced oxygen consumption rates (OCR) and ATP production indicating altered cellular metabolism.	Oxygen	157-163	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	46-50
19473991-0	2009	Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex.	Oxygen	125-131	formin 1	Homo sapiens	37-40
33592181-6	2021	Cells expressing other CYPs had an even stronger effect, with those expressing CYP2B6, CYP5A1, CYP2A13, CYP51A1, or CYP1A2, respectively, being the strongest producers of O2- .	Oxygen	171-174	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	95-102
14063237-0	1963	CALF BLOOD FLOW AND OXYGEN USAGE DURING BRADYKININ INFUSIONS.	Oxygen	20-26	kininogen 1	Bos taurus	40-50
19406381-0	2009	Analysis of gene expression profiles in human periodontal ligament cells under hypoxia: the protective effect of CC chemokine ligand 2 to oxygen shortage.	Oxygen	138-144	C-C motif chemokine ligand 2	Homo sapiens	113-134
33267953-2	2021	Herein, a facile adsorption-pyrolyzation strategy is proposed for preparing ultrafine Ni nanoparticles anchored on carbon nanofiber (Ni/CNF), which derives from pyrolyzation of bacterial cellulose (BC) (with pre-adsorbed of Ni2+) via a two-step heat-treatment procedure (firstly 360 C, and then 750 C) (Ni/CNF-750) and used as an excellent oxygen electrocatalyst for flexible all solid-state Zn-air cell.	Oxygen	340-346	NPHS1 adhesion molecule, nephrin	Homo sapiens	136-139
13960585-0	1963	[Effect of oxygen under pressure and methionine sulfoximine on the activity of glutamine synthetase in the rat brain].	Oxygen	11-17	glutamate-ammonia ligase	Rattus norvegicus	79-99
19406381-8	2009	However, the exogenous CCL2 prevented PDL cell death under oxygen shortage with the increment of cellular inhibitor of apoptosis (cIAP) mRNA expression.	Oxygen	59-65	C-C motif chemokine ligand 2	Homo sapiens	23-27
19541622-6	2009	This study indicates that monooxygenase and oxidase flavoenzymes employ multiple funnel-shaped diffusion pathways to absorb O(2) from the solvent and direct it to the reacting C4a atom of the flavin cofactor.	Oxygen	124-128	complement C4A (Rodgers blood group)	Homo sapiens	176-179
13906371-2	1962	The exchange of oxygen through the membrane was studied by means of oxygen-18, and it grossly exceeded that obtained with membranes containing methemoglobin or only water.	Oxygen	16-22	hemoglobin subunit gamma 2	Homo sapiens	143-156
33787203-4	2021	The GOx utilizes glucose to produce hydrogen peroxide, which is subsequently degraded by Cat, resulting in the generation of active radicals and/or oxygen bubbles that propel the particles.	Oxygen	148-154	hydroxyacid oxidase 1	Homo sapiens	4-7
19375411-0	2009	Evidence for H(2)O(2) as the product of reduction of oxygen by alternative oxidase in mitochondria from potato tubers.	Oxygen	53-59	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	63-82
33833221-7	2021	Mutant KRAS increased the production of reactive oxygen species, an inhibitor of prolyl hydroxylase activity which decreases HIF-1alpha hydroxylation, leading to enhanced HIF-1alpha stabilization.	Oxygen	49-55	KRAS proto-oncogene, GTPase	Homo sapiens	7-11
14937496-0	1952	[Diffusion constant of oxygen in methemoglobin solutions of different concentrations].	Oxygen	23-29	hemoglobin subunit gamma 2	Homo sapiens	33-46
19375411-1	2009	Oxygen consumption by alternative oxidase (AOX), present in mitochondria of many angiosperms, is known to be cyanide-resistant in contrast to cytochrome oxidase.	Oxygen	0-6	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	22-41
18890028-0	1948	Metabolism, toxicity, and manner of action of gold compounds in the treatment of arthritis; the effect of BAL and other thiol compounds in preventing the inhibition of oxygen consumption of rat tissues produced by gold salts.	Oxygen	168-174	solute carrier family 27 member 5	Rattus norvegicus	106-109
33144006-4	2021	The results of XRD, TEM, XPS and H2-TPR reveal that the electric field show negligible influence on the crystal structure and surface morphology of the catalyst, but it can lead to more oxygen vacancies.	Oxygen	186-192	translocated promoter region, nuclear basket protein	Homo sapiens	36-39
20342885-0	1947	Some effects of cytochrome c on the oxygen economy of anesthetized dogs.	Oxygen	36-42	cytochrome c, somatic	Canis lupus familiaris	16-28
19375411-1	2009	Oxygen consumption by alternative oxidase (AOX), present in mitochondria of many angiosperms, is known to be cyanide-resistant in contrast to cytochrome oxidase.	Oxygen	0-6	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	43-46
33964699-2	2021	Herein, an intelligent reactive oxygen species (ROS) nanogenerator Ce6/GOx@ZIF-8/PDA@MnO2 (denoted as CGZPM; Ce6, GOx, ZIF-8, PDA, MnO2 are chlorin e6, glucose oxidase, zeolitic imidazolate framework-8, polydopamine and manganese dioxide respectively) with O2-generating and GSH-/glucose-depleting abilities was constructed by a facile and green one-pot method.	Oxygen	87-89	hydroxyacid oxidase 1	Homo sapiens	71-74
19445502-2	2009	Ultrasensitive SERS detection of p-nitrophenol can be achieved when oxidation of surface-immobilized Ag nanoparticles is inhibited by replacing the oxygen dissolved in water with argon gas.	Oxygen	148-154	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	15-19
33964699-2	2021	Herein, an intelligent reactive oxygen species (ROS) nanogenerator Ce6/GOx@ZIF-8/PDA@MnO2 (denoted as CGZPM; Ce6, GOx, ZIF-8, PDA, MnO2 are chlorin e6, glucose oxidase, zeolitic imidazolate framework-8, polydopamine and manganese dioxide respectively) with O2-generating and GSH-/glucose-depleting abilities was constructed by a facile and green one-pot method.	Oxygen	87-89	hydroxyacid oxidase 1	Homo sapiens	114-117
33964699-4	2021	The Mn2+ acted as an ideal Fenton-like agent and magnetic resonance (MR) imaging contrast agent, while the O2 promoted the PDT via hypoxia relief and facilitated the intratumoral glucose oxidation by GOx for starvation therapy (ST).	Oxygen	107-109	hydroxyacid oxidase 1	Homo sapiens	200-203
21018771-0	1946	The introduction of oxygen into the steroid nucleus at the C11 position.	Oxygen	20-26	RNA polymerase III subunit K	Homo sapiens	59-62
19508692-2	2009	HIF-1 alpha is one of the major transcription factors responding to low oxygen tension and can differentially regulate a large number of target genes.	Oxygen	72-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-11
34030369-7	2021	In the STP outlets, a strict decline of biochemical oxygen demand, >95% removal of caffeine, and absence of viral copies reflect the efficiency of the treatment plants in Chennai city.	Oxygen	52-58	thyroid hormone receptor interactor 10	Homo sapiens	7-10
32572800-8	2021	Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-alpha (P <= 0.0001) and IL-10 (P <= 0.012) contents, and significant elevation in IFN-gamma (P <= 0.0002) content on day 14 post-therapy.	Oxygen	41-44	interferon gamma	Bos taurus	172-181
33444648-3	2021	Since mitochondria are the main oxygen sensors as well as the principal producers of ROS, it can be presumed that they may be able to modulate the activity of CRL3KEAP1 and CRL2VHL complexes in response to stress.	Oxygen	32-38	DAN domain BMP antagonist family member 5	Homo sapiens	173-180
19321442-0	2009	PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.	Oxygen	93-99	protein interacting with PRKCA 1	Homo sapiens	0-5
33865914-4	2021	Similarly, Drosophila globin1 (a homologue of human globin) with its known roles in oxygen management and development of nervous system exhibits striking similarities with the mammalian neuroglobin.	Oxygen	84-90	neuroglobin	Homo sapiens	186-197
33865914-11	2021	In view of the fact that human genome encodes for the multiple Globin proteins including a nervous system specific neuroglobin; and therefore, our findings may pave the way to investigate if the conserved oxygen sensing globin gene(s) can be exploited in devising novel therapeutic strategies against tauopathies.	Oxygen	205-211	neuroglobin	Homo sapiens	115-126
34052998-5	2021	Towards understanding the role of 2,3-BPG in the oocyte, we characterized gene expression and protein abundance of bisphosphoglycerate mutase (Bpgm), which synthesizes 2,3-BPG, and whether this is altered under low oxygen or hemoglobin addition during IVM.	Oxygen	215-221	2,3-bisphosphoglycerate mutase	Mus musculus	143-147
19364645-8	2009	In conclusion, our data indicate that the absence of a hydrogen-bond donor on the C(6) oxygen enhances rather than impedes the in vitro affinity of naltrexol derivatives for the MOR.	Oxygen	87-93	opioid receptor mu 1	Homo sapiens	178-181
34052998-13	2021	Decreasing oxygen concentration and the addition of hemoglobin altered Bpgm, albeit not to levels observed in vivo.	Oxygen	11-17	2,3-bisphosphoglycerate mutase	Mus musculus	71-75
33904834-8	2021	eIF2alpha phosphorylation was also reduced after 48h by low oxygen (-61%; P < 0.05), but increased in the presence of insulin (+46%; P <= 0.01).	Oxygen	60-66	eukaryotic translation initiation factor 2A	Homo sapiens	0-9
33904834-10	2021	Overall, our results suggest that IRE1alpha and eIF2alpha UPR-pathways are differentially regulated by oxygen and insulin in early pregnancy.	Oxygen	103-109	eukaryotic translation initiation factor 2A	Homo sapiens	48-57
33792566-6	2021	Transcriptional studies implicated hypoxia-inducible factor-1alpha (HIF1alpha) in the induction of miR122 and identified the oxygen-sensing prolyl hydroxylase domain 1 (PHD1) as a miR122 target.	Oxygen	125-131	egl-9 family hypoxia-inducible factor 2	Mus musculus	140-167
33792566-6	2021	Transcriptional studies implicated hypoxia-inducible factor-1alpha (HIF1alpha) in the induction of miR122 and identified the oxygen-sensing prolyl hydroxylase domain 1 (PHD1) as a miR122 target.	Oxygen	125-131	egl-9 family hypoxia-inducible factor 2	Mus musculus	169-173
19409522-3	2009	Erv1p is reoxidized within this system, transferring its electrons to molecular oxygen through interactions with cytochrome c and cytochrome c oxidase (COX), thereby linking the DRS to the respiratory chain.	Oxygen	80-86	growth factor, augmenter of liver regeneration	Homo sapiens	0-5
34012567-7	2021	Results: The amounts of elastin, muscle, and collagen and the protein levels of ET-1, HIF-1alpha, Rock-1, and MMP-2, increased significantly with decreased oxygen saturation in the perfusion circuit.	Oxygen	156-162	elastin	Homo sapiens	24-31
33724516-9	2021	Reactive oxygen species and LDs induced by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1 hepa .	Oxygen	9-15	kelch-like ECH-associated protein 1	Mus musculus	125-130
34036787-6	2021	The Ag@NiFe/NF electrode displayed overpotentials as low as 180 and 80 mV for oxygen and hydrogen evolution, respectively, at a current density of 10 mA cm-2, and improvements in the specific activity by ~5x and ~1.5x for the oxygen and hydrogen evolution reaction, respectively, compared to benchmark NiFe hydroxide materials.	Oxygen	78-84	neurofascin	Homo sapiens	12-14
34036787-6	2021	The Ag@NiFe/NF electrode displayed overpotentials as low as 180 and 80 mV for oxygen and hydrogen evolution, respectively, at a current density of 10 mA cm-2, and improvements in the specific activity by ~5x and ~1.5x for the oxygen and hydrogen evolution reaction, respectively, compared to benchmark NiFe hydroxide materials.	Oxygen	226-232	neurofascin	Homo sapiens	12-14
34052625-4	2021	Here, we demonstrate that severe hypoxia (1% O2) upregulates CD44 expression via activation of hypoxia-inducible factor (HIF-1alpha), inducing GSCs to assume a highly invasive tumor.	Oxygen	45-47	CD44 antigen	Mus musculus	61-65
33709773-9	2021	In vitro experiments in Fbn1-silenced VSMCs presented increased lactate production and decreased oxygen consumption.	Oxygen	97-103	fibrillin 1	Mus musculus	24-28
33350013-0	2021	Spin state tunes oxygen atom transfer towards FeIVO formation in FeII complexes.	Oxygen	17-23	spindlin 1	Homo sapiens	0-4
33709221-0	2021	Application of a dissolved oxygen control strategy to increase the expression of Streptococcus suis glutamate dehydrogenase in Escherichia coli.	Oxygen	27-33	glutamate dehydrogenase	Escherichia coli	100-123
19358330-9	2009	FGFR2-Tg-ECs exposed to 1% oxygen exhibited enhanced phosphorylation of 416-Tyr-Src, 473-Ser-Akt, and HIF1alpha accumulation.	Oxygen	27-33	Rous sarcoma oncogene	Mus musculus	80-83
34031767-11	2021	Expressions of BNIP3, ENO1, GAPDH, and SLC2A1, were upregulated in 7% oxygen/low glucose, compared to 20% oxygen groups.	Oxygen	70-76	BCL2 interacting protein 3	Bos taurus	15-20
19220812-4	2009	In addition, low oxygen concentrations induced the active export of COMMD1 from the nucleus in a CRM1-dependent manner.	Oxygen	17-23	exportin 1	Homo sapiens	97-101
34031767-11	2021	Expressions of BNIP3, ENO1, GAPDH, and SLC2A1, were upregulated in 7% oxygen/low glucose, compared to 20% oxygen groups.	Oxygen	70-76	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	28-33
34031767-11	2021	Expressions of BNIP3, ENO1, GAPDH, and SLC2A1, were upregulated in 7% oxygen/low glucose, compared to 20% oxygen groups.	Oxygen	106-112	BCL2 interacting protein 3	Bos taurus	15-20
34031767-12	2021	BNIP3 expression was higher in 7% oxygen group with low glucose availability compared to the 20% groups.	Oxygen	34-40	BCL2 interacting protein 3	Bos taurus	0-5
33245183-7	2021	Atomic-resolution crystal structures of the precatalytic complex of FGE demonstrate that this enzyme binds O2 juxtaposed, but not coordinated to the catalytic CuI.	Oxygen	107-109	sulfatase modifying factor 1	Homo sapiens	68-71
33245183-8	2021	Isostructural complexes that contain AgI instead of CuI or nitric oxide instead of O2 confirm that formation of the initial oxygenated complex of FGE does not depend on redox activity.	Oxygen	83-85	sulfatase modifying factor 1	Homo sapiens	146-149
19154183-1	2009	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1alpha and the partner factor ARNT [AhR (aryl hydrocarbon receptor) nuclear translocator].	Oxygen	201-207	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	260-264
33666761-3	2021	IL-17A promotes an increase in blood pressure through multiple mechanisms including inhibiting endothelial nitric oxide production, increasing reactive oxygen species formation, promoting vascular fibrosis, and enhancing renal sodium retention and glomerular injury.	Oxygen	152-158	interleukin 17A	Homo sapiens	0-6
34003544-3	2021	The expression of SNHG1 was determined in human BC cells cultured in hypoxia (1% O2 , 24 h) and normoxia (20% O2 , 24 h).	Oxygen	81-83	small nucleolar RNA host gene 1	Homo sapiens	18-23
34003544-3	2021	The expression of SNHG1 was determined in human BC cells cultured in hypoxia (1% O2 , 24 h) and normoxia (20% O2 , 24 h).	Oxygen	110-112	small nucleolar RNA host gene 1	Homo sapiens	18-23
19356718-3	2009	Animals lacking these neuropeptides, encoded by the flp-18 gene, are defective in chemosensation and foraging, accumulate excess fat, and exhibit reduced oxygen consumption.	Oxygen	154-160	SVPGVLRF-amide 3	Caenorhabditis elegans	52-58
33693655-2	2021	The molecular mechanism by which insulin signaling regulates these vital processes is dependent on the nutrient status and oxygen availability of the organism.	Oxygen	123-129	Insulin-like receptor	Drosophila melanogaster	33-40
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	receptor for activated C kinase 1	Homo sapiens	52-92
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	receptor for activated C kinase 1	Homo sapiens	94-99
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	receptor for activated C kinase 1	Homo sapiens	122-127
33850635-6	2021	Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1alpha, thus protecting HIF-1alpha from RACK1-induced oxygen-independent degradation.	Oxygen	202-208	receptor for activated C kinase 1	Homo sapiens	122-127
33569838-4	2021	As a proof-of-concept application, gamma-FeOOH NAs are developed as electrocatalysts for the oxygen evolution reaction (OER), where the sample grown on nickel foam (NF) exhibits superior performance of high catalytic current density, small Tafel slope, and exceptional durability, which is among the top level of FeOOH-based electrocatalysts.	Oxygen	93-99	neurofascin	Homo sapiens	165-167
19348046-3	2009	report that increasing oxygen tension in tumor cells by ectopically expressing the oxygen-binding hemoprotein myoglobin indeed affects tumorigenesis (see the related article beginning on page 865).	Oxygen	23-29	myoglobin	Homo sapiens	110-119
33998543-10	2021	Accordingly, PINK1-overexpressed AD cybrids exhibit increases in mitochondrial length and density and suppressed reactive oxygen species.	Oxygen	122-128	PTEN induced kinase 1	Homo sapiens	13-18
19348046-3	2009	report that increasing oxygen tension in tumor cells by ectopically expressing the oxygen-binding hemoprotein myoglobin indeed affects tumorigenesis (see the related article beginning on page 865).	Oxygen	83-89	myoglobin	Homo sapiens	110-119
33608066-9	2021	H19 overexpression in oxygen-glucose deprivation neurons increased B-cell lymphoma-2 and decreased B-cell lymphoma-2-associated X, total and cleaved caspase-3 expressions.	Oxygen	22-28	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	0-3
34054836-2	2021	In fish, IFNgamma stimulates the expression of cytokines and chemokines associated with the pro-inflammatory response and enhances the production of nitrogen and oxygen reactive species in phagocytic cells.	Oxygen	162-168	interferon gamma	Salmo salar	9-17
19221500-2	2009	Here we demonstrate that in response to limited oxygen conditions PTEN and p53 work in tandem to induce maspin in glioblastoma cells.	Oxygen	48-54	transformation related protein 53, pseudogene	Mus musculus	75-78
33404366-8	2021	We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2.	Oxygen	145-147	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	74-79
33404366-8	2021	We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2.	Oxygen	145-147	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	80-85
33978488-6	2021	The most plausible cause for this finding is formation of methemoglobin, which increases the oxygen affinity and thus apparently compensates for the 2,3-BPG effect.	Oxygen	93-99	hemoglobin subunit gamma 2	Homo sapiens	58-71
33988159-12	2021	In addition, there was a significant correlation between serum levels of sirtuin-1 and KPS, O2 saturation, and smoking history.	Oxygen	92-94	sirtuin 1	Homo sapiens	73-82
33095400-3	2021	ET-1 activates PKC-alpha in the caveolae vesicles by O2.- derived from PKCzeta-NADPH oxidase dependent pathway.	Oxygen	53-55	endothelin 1	Bos taurus	0-4
33095400-3	2021	ET-1 activates PKC-alpha in the caveolae vesicles by O2.- derived from PKCzeta-NADPH oxidase dependent pathway.	Oxygen	53-55	protein kinase C alpha	Bos taurus	15-24
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	ATP binding cassette subfamily C member 2	Homo sapiens	171-179
32978975-3	2021	We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including down-regulation of ENT1, OATP4A1, OCTN2, BCRP, MRP2/3/5, and up-regulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1.	Oxygen	30-36	solute carrier family 28 member 1	Homo sapiens	202-206
33908761-3	2021	Structural pairing across the O2 edges induces antiferromagnetic spin dimers (S = 0) with J/Kb   300 K, ~15 times greater than the exchange across the F2 bridges, within a non-ordered magnetic ground state.	Oxygen	30-32	spindlin 1	Homo sapiens	65-69
19221500-2	2009	Here we demonstrate that in response to limited oxygen conditions PTEN and p53 work in tandem to induce maspin in glioblastoma cells.	Oxygen	48-54	serine (or cysteine) peptidase inhibitor, clade B, member 5	Mus musculus	104-110
19221500-8	2009	The integration of PTEN and p53 into a common pathway for the induction of another tumor suppressor, Maspin, constitutes a tumor suppressor network of PTEN/p53/Mapsin that is operational under limited oxygen conditions.	Oxygen	201-207	transformation related protein 53, pseudogene	Mus musculus	28-31
33127052-0	2021	Enriched oxygen vacancies of Cu2O/SnS2/SnO2 heterostructure for enhanced photocatalytic reduction of CO2 by water and nitrogen fixation.	Oxygen	9-15	strawberry notch homolog 2	Homo sapiens	39-42
19221500-8	2009	The integration of PTEN and p53 into a common pathway for the induction of another tumor suppressor, Maspin, constitutes a tumor suppressor network of PTEN/p53/Mapsin that is operational under limited oxygen conditions.	Oxygen	201-207	serine (or cysteine) peptidase inhibitor, clade B, member 5	Mus musculus	101-107
33881067-6	2021	Benefiting from the mesoporous feature, small size, defect-rich surface and carbon coating, the obtained mesoporous Pd/C nanodendrites exhibit great electrocatalytic performance toward the oxygen reduction reaction (ORR).	Oxygen	189-195	phosducin	Homo sapiens	116-120
19221500-8	2009	The integration of PTEN and p53 into a common pathway for the induction of another tumor suppressor, Maspin, constitutes a tumor suppressor network of PTEN/p53/Mapsin that is operational under limited oxygen conditions.	Oxygen	201-207	transformation related protein 53, pseudogene	Mus musculus	156-159
19188249-5	2009	In addition, leptin synthesis and plasma concentration can be modified by insulin, glucocorticoids, thyroid hormones and oxygen availability in utero, and therefore, leptin may be part of the hormonal response to changes in the intrauterine environment.	Oxygen	121-127	leptin	Homo sapiens	13-19
33975346-9	2021	Bioactivity of unlabelled VEGF released from V-SPs was determined by analysis of embryo developmental outcomes (blastocyst developmental rate and total cell number) following individual mouse embryo culture in 20 microl of G1/G2 media at 5% oxygen, supplemented with 10 ng/ml recombinant mouse VEGF in solution or with V-SPs.	Oxygen	241-247	vascular endothelial growth factor A	Mus musculus	26-30
33462138-8	2021	PEPCK-deficient parasites exhibited significantly greater extracellular acidification rate, increased proton leak, and decreased ATP-coupling efficiency and oxygen consumption rates in comparison with their wild-type and addback counterparts.	Oxygen	157-163	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-5
19136605-8	2009	In addition, G-CSF dramatically improved ATP generation, which rescued Dox-impaired mitochondrial electron transport and oxygen consumption mainly through complex IV.	Oxygen	121-127	colony stimulating factor 3	Homo sapiens	13-18
33618181-7	2021	LPCAT1 was maximally upregulated at 4% O2 (P < 0.01), corresponding to oxygen tension found in placenta at term.	Oxygen	39-41	lysophosphatidylcholine acyltransferase 1	Homo sapiens	0-6
33618181-7	2021	LPCAT1 was maximally upregulated at 4% O2 (P < 0.01), corresponding to oxygen tension found in placenta at term.	Oxygen	71-77	lysophosphatidylcholine acyltransferase 1	Homo sapiens	0-6
33984636-6	2021	GOx would rapidly exhaust endogenous glucose and O2 to shut off the energy supply of tumor cells for starvation treatment.	Oxygen	49-51	hydroxyacid oxidase 1	Homo sapiens	0-3
19212676-8	2009	SPARC expression was upregulated under hypoxic stress of 1% oxygen concentration in glioma cells.	Oxygen	60-66	secreted protein acidic and cysteine rich	Homo sapiens	0-5
33890773-0	2021	Dual Active Center-Assembled Cu31S16-Co9-xNixS8 Heterodimers: Coherent Interface Engineering Induces Multihole Accumulation for Light-Enhanced Electrocatalytic Oxygen Evolution.	Oxygen	160-166	phosphoserine phosphatase pseudogene 1	Homo sapiens	37-40
33934112-6	2021	Our data identify TRAP1 as a primary regulator of mitochondrial bioenergetics in highly proliferating cells following reduction in oxygen tension and HIF1alpha stabilization.	Oxygen	131-137	TNF receptor-associated protein 1	Danio rerio	18-23
33853303-8	2021	Weak correlation was observed between netrin-1 level at admission and FEV1, FVC, partial pressure of oxygen, and CRP levels (r= 0.394, p= 0.01; r= -0.366, p= 0.01; r= -0.19, p= 0.05; r= 0.306, p= 0.01).	Oxygen	101-107	netrin 1	Homo sapiens	38-46
18930903-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that plays an essential role in oxygen homeostasis.	Oxygen	103-109	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
33611266-16	2021	Methemoglobinemia means the abnormally elevated level of methemoglobin in the blood, which is incapable of oxygen transport, accordingly it can cause significant tissue hypoxia, leading to severe or even life-threatening clinical symptoms.	Oxygen	107-113	hemoglobin subunit gamma 2	Homo sapiens	57-70
18930903-1	2009	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that plays an essential role in oxygen homeostasis.	Oxygen	103-109	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	Oxygen	330-336	sluggish A	Drosophila melanogaster	140-161
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	Oxygen	330-336	sluggish A	Drosophila melanogaster	163-168
33927247-5	2021	Aerobic fitness, assessed by peak oxygen utilization on a high-intensity exercise test (VO2 peak), was positively associated with the volumetric enlargement of the hippocampal head, and the CA1 head region specifically.	Oxygen	34-40	carbonic anhydrase 1	Homo sapiens	190-193
33908449-3	2021	In this study, a novel CD44 receptor-targeted and redox/ultrasound-responsive oxygen-carrying nanoplatform was constructed using chondroitin sulfate (CS), reactive oxygen species (ROS)-generating sonosensitizer Rhein (Rh), and perfluorocarbon (PFC).	Oxygen	78-84	CD44 antigen	Mus musculus	23-27
33909926-7	2021	These observations suggested that ER stress and the generation of reactive oxygen species are essential for the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA in keratinocytes.	Oxygen	75-81	C-X-C motif chemokine ligand 10	Homo sapiens	158-164
33688389-9	2021	Furthermore, the Panx-1 channel blockade was associated with an increase in O2  - production.	Oxygen	76-81	Pannexin 1	Rattus norvegicus	17-23
19111934-1	2009	Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a monomeric enzyme that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the phenolic oxygen of substituted catechols.	Oxygen	170-176	catechol-O-methyltransferase	Rattus norvegicus	0-28
33598944-5	2021	Death is a consequence of oxidation of hemoglobin ferrous (Fe+2 ) iron (Hb) to the ferric (Fe+3 ) form (methemoglobin, MetHb), causing a reduction in the oxygen-carrying capacity of the blood.	Oxygen	154-160	hemoglobin subunit gamma 2	Homo sapiens	104-117
33925659-4	2021	Human bone marrow-derived mesenchymal stem cells (BM-hMSCs, passage 1) isolated in reduced oxygen conditions displayed an upregulation of SOX2 in reduced oxygen conditions vs. air oxygen (21% O2, AO), while no change was noted for either OCT-4 or NANOG.	Oxygen	91-97	SRY-box transcription factor 2	Homo sapiens	138-142
33925659-4	2021	Human bone marrow-derived mesenchymal stem cells (BM-hMSCs, passage 1) isolated in reduced oxygen conditions displayed an upregulation of SOX2 in reduced oxygen conditions vs. air oxygen (21% O2, AO), while no change was noted for either OCT-4 or NANOG.	Oxygen	154-160	SRY-box transcription factor 2	Homo sapiens	138-142
33925659-4	2021	Human bone marrow-derived mesenchymal stem cells (BM-hMSCs, passage 1) isolated in reduced oxygen conditions displayed an upregulation of SOX2 in reduced oxygen conditions vs. air oxygen (21% O2, AO), while no change was noted for either OCT-4 or NANOG.	Oxygen	154-160	SRY-box transcription factor 2	Homo sapiens	138-142
19111934-1	2009	Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a monomeric enzyme that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the phenolic oxygen of substituted catechols.	Oxygen	170-176	catechol-O-methyltransferase	Rattus norvegicus	30-34
19267995-7	2009	Given the abundance of cytochrome c in the intermembrane space of mitochondria, the cellular location of PPO, this process may potentially impact on the synthesis of heme in vivo particularly in conditions of low oxygen or hypoxia.	Oxygen	213-219	Protoporphyrinogen oxidase	Drosophila melanogaster	105-108
33892719-1	2021	BACKGROUND: Biallelic loss-of-function variants in NCF1 lead to reactive oxygen species deficiency and chronic granulomatous disease (CGD).	Oxygen	73-79	neutrophil cytosolic factor 1	Homo sapiens	51-55
33010380-3	2021	METHODS AND RESULTS: Percutaneous oxygen saturation (SpO2) was analyzed during flight in 11 Fontan patients and eight volunteers.	Oxygen	34-40	spookier	Drosophila melanogaster	53-57
19577710-6	2009	Recently, leukemia inhibitory factor secreted from endothelial cells was shown to act cooperatively with oxygen as a negative feedback signal.	Oxygen	105-111	LIF interleukin 6 family cytokine	Homo sapiens	10-36
33543742-0	2021	Rod-like nickel doped Co3Se4/reduced graphene oxide hybrids as efficient electrocatalysts for oxygen evolution reactions.	Oxygen	94-100	kinetochore associated 1	Homo sapiens	0-3
33871764-1	2022	Almost since its introduction pulse oximetry was known to overestimate oxygen saturation in cases of carbon monoxide poisoning or elevated methemoglobin (metHb) levels.	Oxygen	71-77	hemoglobin subunit gamma 2	Homo sapiens	139-152
33573690-9	2021	RESULTS: PSF ameliorated retinal neovascularization and corrected abnormal VEGF expression in mice with oxygen-induced retinopathy and reduced intra-retinal neovascularization in Vldlr - / - mice.	Oxygen	104-110	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	Mus musculus	9-12
19073140-0	2009	Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase.	Oxygen	88-90	abhydrolase domain containing 1	Mus musculus	0-22
33578723-0	2021	Function of Hemoglobin-Based Oxygen Carriers: Determination of Methemoglobin Content by Spectral Extinction Measurements.	Oxygen	29-35	hemoglobin subunit gamma 2	Homo sapiens	63-76
33388585-3	2021	By virtue of the introduced Fe and Mn elements and unique flower-like structures, the as-prepared catalyst displayed high activity and stability for oxygen evolution reaction (OER), coupled with a small Tafel slope (63.29 mV dec-1) and a low overpotential of 216 mV to reach the current density of 30 mA cm-2.	Oxygen	149-155	general transcription factor IIE subunit 1	Homo sapiens	28-30
33847405-7	2022	Notably, the percent of pulmonary effector CD8+ GrB+ IFNgamma+ T cells at day 10 post-infection correlated positively with total CD8+ basal extracellular acidification rate and basal oxygen consumption rate.	Oxygen	183-189	CD8a molecule	Homo sapiens	43-46
18992727-0	2009	Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.	Oxygen	123-129	estrogen receptor 1	Rattus norvegicus	19-36
33830082-8	2021	Higher miR-122 expression in nasopharyngeal aspirates was associated with a longer time on oxygen therapy and a higher rate of treatment failure in 87 infants hospitalized with moderately severe bronchiolitis.	Oxygen	91-97	microRNA 122	Homo sapiens	7-14
33465212-3	2021	In this nanosystem, the loaded Dex can not only expand the pores of the nucleus to promote GOx to enter the nucleus, addressing the shortcomings of short life of reactive oxygen species, but also inhibit the production of collagen to reshape the tumor microenvironment and inhibit lung metastasis.	Oxygen	171-177	hydroxyacid oxidase 1	Homo sapiens	91-94
19052874-8	2009	Hyperbaric oxygen caused a loss of mitochondrial membrane potential and caspase-9 induction.	Oxygen	11-17	caspase 9	Homo sapiens	72-81
33586916-9	2021	RESULTS: Animal under 7% O2  + 93% N2 condition for 3 hr showed the highest cognitive behavior impairment and upregulated HIF-1alpha and BACE1 mRNA in brains of offspring (p < .001).	Oxygen	25-30	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	122-132
33586916-9	2021	RESULTS: Animal under 7% O2  + 93% N2 condition for 3 hr showed the highest cognitive behavior impairment and upregulated HIF-1alpha and BACE1 mRNA in brains of offspring (p < .001).	Oxygen	25-30	beta-secretase 1	Rattus norvegicus	137-142
18973838-7	2009	A high oxygen tension markedly prolonged the duration of osteoclast precursor formation in the presence of supporting cells, and also markedly and persistently increased the production of macrophage colony stimulating factor (M-CSF) by supporting cells.	Oxygen	7-13	colony stimulating factor 1	Homo sapiens	188-224
33319462-7	2021	Additionally, serum endocan levels were negatively correlated with FVC, FEV1, partial oxygen pressure, and oxygen saturation (r= -0.30, p=0.03; r= -0.34, p=0.01; r= -0.34, p=0.01 and r= -0.36, p=0.007, respectively), and positively correlated with disease duration and systolic pulmonary artery pressure (r=0.47, p<0.001; r=0.31, p=0.02, respectively).	Oxygen	86-92	endothelial cell specific molecule 1	Homo sapiens	20-27
33319462-7	2021	Additionally, serum endocan levels were negatively correlated with FVC, FEV1, partial oxygen pressure, and oxygen saturation (r= -0.30, p=0.03; r= -0.34, p=0.01; r= -0.34, p=0.01 and r= -0.36, p=0.007, respectively), and positively correlated with disease duration and systolic pulmonary artery pressure (r=0.47, p<0.001; r=0.31, p=0.02, respectively).	Oxygen	107-113	endothelial cell specific molecule 1	Homo sapiens	20-27
33785835-0	2021	In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway.	Oxygen	3-9	polo like kinase 1	Homo sapiens	99-103
33253911-9	2021	In addition, the BDNF/KLF2 pathway preserved the mitochondrial membrane potential, intracellular reactive oxygen species generation, electron transport chain processing, oxygen consumption rate, and adenosine triphosphate production.	Oxygen	106-112	brain derived neurotrophic factor	Homo sapiens	17-21
18973838-7	2009	A high oxygen tension markedly prolonged the duration of osteoclast precursor formation in the presence of supporting cells, and also markedly and persistently increased the production of macrophage colony stimulating factor (M-CSF) by supporting cells.	Oxygen	7-13	colony stimulating factor 1	Homo sapiens	226-231
33564671-9	2021	As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target.	Oxygen	125-131	azurocidin 1	Homo sapiens	142-145
18634015-10	2009	Although the in vitro responses of chondrocytes to hypoxia were similar between RA and OA samples, the in vivo expression of ANGPTL4 had unique disease-specific patterns, suggesting differences in oxygen tension in vivo.	Oxygen	197-203	angiopoietin like 4	Homo sapiens	125-132
33359261-0	2021	An exacerbated metabolism and mitochondrial reactive oxygen species contribute to mitochondrial alterations and apoptosis in CD4 T cells during the acute phase of Trypanosoma cruzi infection.	Oxygen	53-59	CD4 antigen	Mus musculus	125-128
33583153-13	2021	Changes in methemoglobin concentration and tissue oxygen saturation are indicative of the temporary production of methemoglobin and severe hypoxemia during methemoglobinemia.	Oxygen	50-56	hemoglobin subunit gamma 2	Homo sapiens	114-127
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Oxygen	135-141	acyl-CoA oxidase 1	Homo sapiens	4-23
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Oxygen	135-141	acyl-CoA oxidase 1	Homo sapiens	25-28
33372032-8	2021	Interestingly, degeneration of BDNF-dependent sensory neurons requires BAX and appears to rely on reactive oxygen species generation rather than caspases to induce degeneration.	Oxygen	107-113	brain derived neurotrophic factor	Homo sapiens	31-35
33249154-11	2021	Molecular docking analysis revealed the formation of several H-bonding interactions through the ester carbonyl and the nitro oxygens of 3c with the side chains of His348, Arg212 and His279 in the active pocket of alpha-glucosidase whereas 3b interacted with His95, -OH of Thr197, Thr198 and WAT462 in the active site of carbonic anhydrase-II.	Oxygen	125-132	carbonic anhydrase 2	Homo sapiens	320-341
33519668-11	2020	Both MALAT1 downregulation and miR-375 upregulation reversed the inhibitory effect of oxygen and glucose deprivation (OGD)/R on cell viability and the promoting effects on LDH level, cell apoptosis, and inflammatory factors levels.	Oxygen	86-92	microRNA 375	Rattus norvegicus	31-38
33418837-9	2021	Three SIRT1 isoforms had a differential effect on the mitochondrial oxygen consumption rate.	Oxygen	68-74	sirtuin 1	Homo sapiens	6-11
33400016-6	2021	Finally, our animal study also showed that intravitreal injection of small interfering RNA of YAP or PFKFB3 dramatically suppressed the neovascular growth in mouse models of choroidal neovascularization and oxygen-induced retinopathy.	Oxygen	207-213	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	101-107
33218686-3	2021	In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration.	Oxygen	27-29	serine/threonine protein kinase YCK1	Saccharomyces cerevisiae S288C	135-141
32605929-10	2021	This epigenetic activity of JMJD1 proteins is sensitive to heavy metals, oncometabolites, oxygen and reactive oxygen species, whose levels are frequently altered within cancer cells.	Oxygen	90-96	lysine (K)-specific demethylase 3A	Mus musculus	28-33
32788474-10	2021	In conclusion, Nogo-A aggravated reactive oxygen species damage in oligodendrocytes, and phosphorylated extracellular signal-regulated kinase 1/2 and BCL2 might be involved in this process.	Oxygen	42-48	reticulon 4	Rattus norvegicus	15-21
33729069-5	2021	This article summarized the four characteristics of DDIT4 including a mitochondria-related protein, interactions with various protein molecules, immune and metabolic cell related proteins and participator in the oxygen sensing pathway, which may be related to the progress of cancer.	Oxygen	212-218	DNA damage inducible transcript 4	Homo sapiens	52-57
33645072-18	2021	The network pharmacology analysis showed that the action targets were significantly enriched in 129 of biological processes, such as response to organic substance, chemical and oxygen-containing compound, etc., as well as 16 of signal pathways, such as IL-17, TNF and hepatitis B signal pathways, were enriched too.	Oxygen	177-183	interleukin 17A	Mus musculus	253-258
33300905-3	2020	Due to the strong attraction of the Fe ion, the O-O bond length of the O2 molecule is elongated, which decreases the bonding energy between the O atoms.	Oxygen	71-73	general transcription factor IIE subunit 1	Homo sapiens	36-38
33300905-5	2020	When N atoms are doped into the graphene, the interactions between the Fe ions and O2 molecules are stronger, and the O-O bond lengths are elongated further, which makes the desorption of the quasi-CO2 molecule easier.	Oxygen	83-85	general transcription factor IIE subunit 1	Homo sapiens	71-73
33391015-0	2020	Effect of Transcriptional Regulatory Factor FoxO3a on Central Nervous System Oxygen Toxicity.	Oxygen	77-83	forkhead box O3	Mus musculus	44-50
33391023-4	2020	These effects were exacerbated by extra reactive oxygen species, which oxidized CaMKII and led to continuous high CaMKII activation in both systolic and diastolic phases.	Oxygen	49-55	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	80-86
33391023-4	2020	These effects were exacerbated by extra reactive oxygen species, which oxidized CaMKII and led to continuous high CaMKII activation in both systolic and diastolic phases.	Oxygen	49-55	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	114-120
33391175-8	2020	We found a significant relationship between age at epilepsy onset and duration of peri-ictal oxygen desaturation for focal seizures not progressing to bilateral tonic-clonic seizures, with longer duration of peri-ictal oxygen desaturation in patients with epilepsy onset at an older age but no significant relationships between duration of epilepsy or age at EMU admission and ventilatory dysfunction.	Oxygen	93-99	perilipin 1	Homo sapiens	82-86
33391175-8	2020	We found a significant relationship between age at epilepsy onset and duration of peri-ictal oxygen desaturation for focal seizures not progressing to bilateral tonic-clonic seizures, with longer duration of peri-ictal oxygen desaturation in patients with epilepsy onset at an older age but no significant relationships between duration of epilepsy or age at EMU admission and ventilatory dysfunction.	Oxygen	93-99	perilipin 1	Homo sapiens	208-212
33391175-8	2020	We found a significant relationship between age at epilepsy onset and duration of peri-ictal oxygen desaturation for focal seizures not progressing to bilateral tonic-clonic seizures, with longer duration of peri-ictal oxygen desaturation in patients with epilepsy onset at an older age but no significant relationships between duration of epilepsy or age at EMU admission and ventilatory dysfunction.	Oxygen	219-225	perilipin 1	Homo sapiens	82-86
33391175-8	2020	We found a significant relationship between age at epilepsy onset and duration of peri-ictal oxygen desaturation for focal seizures not progressing to bilateral tonic-clonic seizures, with longer duration of peri-ictal oxygen desaturation in patients with epilepsy onset at an older age but no significant relationships between duration of epilepsy or age at EMU admission and ventilatory dysfunction.	Oxygen	219-225	perilipin 1	Homo sapiens	208-212
33320637-5	2020	It was found that the water molecules interacting with one polymer oxygen atom (BW1), of which most are IW molecules, in PMC2A exhibit the lowest mobility, while those in PBA and PMC1A show a higher mobility.	Oxygen	67-73	BW1	Homo sapiens	80-83
33231593-5	2020	Initiated by the breakdown of glucose into gluconic acid and H2O2 by GOx, Fe-PDAP promotes reoxygenation by catalyzing the reaction-supplied and tumor cell-supplied H2O2 into O2, which then enhances the O2-dependent PDT.	Oxygen	63-65	hydroxyacid oxidase 1	Homo sapiens	69-72
33231593-5	2020	Initiated by the breakdown of glucose into gluconic acid and H2O2 by GOx, Fe-PDAP promotes reoxygenation by catalyzing the reaction-supplied and tumor cell-supplied H2O2 into O2, which then enhances the O2-dependent PDT.	Oxygen	167-169	hydroxyacid oxidase 1	Homo sapiens	69-72
33161709-6	2020	From the thermoluminescence glow curves, the trap originating in an oxygen vacancy with a peak at around 270 K was observed.	Oxygen	68-74	TRAP	Homo sapiens	45-49
33291379-9	2020	We demonstrated that Cl2 adsorption is a concurrent process to oxygen adsorption.	Oxygen	63-69	endogenous retrovirus group W member 5	Homo sapiens	21-24
32842901-2	2020	Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.	Oxygen	60-66	Lem3p	Saccharomyces cerevisiae S288C	139-143
33037327-9	2020	Activated CD4+ T cells from obese mice had increased glucose uptake and oxygen consumption rate (OCR), compared to T cells from lean controls, indicating increased mitochondrial oxidation of glucose.	Oxygen	72-78	CD4 antigen	Mus musculus	10-13
31760586-2	2020	Our hypothesis was that CPAP can reduce the incidence and duration of obstructive apnea and hemoglobin oxygen desaturation in patients undergoing procedural sedation for colonoscopy.	Oxygen	103-109	centromere protein J	Homo sapiens	24-28
32740187-14	2020	Statistically significant risk factors for peri-intubation cardiac arrest included: significant systolic dysfunction of the systemic ventricle, pre-intubation hypotension, pre-intubation lactate elevation, lower pre-intubation pH, and documented oxygen desaturations (> 10%) during intubation procedure.	Oxygen	246-252	perilipin 1	Homo sapiens	43-47
33309799-11	2021	This was accompanied by an increased level of superoxide (O2.-), nitric oxide (NO), and peroxynitrite (ONOO-) which were decreased in the presence of NAC, DPI, and 1400W, signifying the role of iNOS-Rac2 interaction.	Oxygen	58-60	X-linked Kx blood group	Homo sapiens	150-153
33470115-3	2021	One of the two radical species is characterized by a long spin-lattice T1 relaxation time equal to 46.9 ms at 5 K and is assigned to the radical center on oxygen.	Oxygen	155-161	spindlin 1	Homo sapiens	58-62
33399444-0	2021	Optimized Conductivity and Spin States in N-Doped LaCoO3 for Oxygen Electrocatalysis.	Oxygen	61-67	spindlin 1	Homo sapiens	27-31
33399444-1	2021	The spin state of antibonding orbital (eg) occupancy in LaCoO3 is recognized as a descriptor for its oxygen electrocatalysis.	Oxygen	101-107	spindlin 1	Homo sapiens	4-8
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	107-113	spindlin 1	Homo sapiens	63-67
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	144-150	spindlin 1	Homo sapiens	63-67
33399444-2	2021	However, the Co(III) cation in typical LaCoO3 (LCO) favors low spin state, which is mediocre for absorbing oxygen-containing groups involved in oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), thus hindering its further development in electrocatalysis.	Oxygen	144-150	spindlin 1	Homo sapiens	63-67
33449026-2	2021	Here the structure of glass networks was tuned through controlling the numbers of non-bridging oxygens and bridging oxygens by adjusting the composition of the glasses, hence increasing the Tm3+ doping concentration of germanate glasses.	Oxygen	116-123	tropomyosin 3	Homo sapiens	190-193
33441618-4	2021	The results from TPO showed that the oxygen consumption rate of the coal samples increased exponentially with increasing temperature.	Oxygen	37-43	thyroid peroxidase	Homo sapiens	17-20
32659589-5	2021	Product analysis revealed that 4-tBP was mainly transformed into hydroxylation products, benzene-ring cleavage products, dimers and higher polymerization products via oxygen atom transfer, ring-opening of the benzene ring and radical coupling reaction.	Oxygen	167-173	TATA-box binding protein	Homo sapiens	33-36
33401440-6	2021	There were significant differences among different ABO blood groups regarding the distribution of oxygen saturation percentage, myalgia, and recovery time after COVID-19 infection (p < 0.01, 0.01, and 0.05, respectively).	Oxygen	98-104	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	51-54
33277104-4	2021	Our previous research has found that brain cortex PIEZO1 expression was increased in the rat model of middle cerebral artery occlusion (MCAO), and PIEZO1 regulated oxygen-glucose deprivation/reoxygenation (OGD/R) injury in neurons through the calcium signaling.	Oxygen	164-170	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	147-153
33125655-2	2021	Herein we present an example of MCPB.py to the parameterization of the dioxygen binding metal site of peptidylglycine-alphahydroxylating monooxygenase (PHM), which contains a copper ion.	Oxygen	71-79	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	102-150
33125655-2	2021	Herein we present an example of MCPB.py to the parameterization of the dioxygen binding metal site of peptidylglycine-alphahydroxylating monooxygenase (PHM), which contains a copper ion.	Oxygen	71-79	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	152-155
32857354-1	2021	Spin trapping with cyclic nitrones coupled to electron paramagnetic resonance (EPR) enables the detection and characterization of oxygen-derived free radicals, such as superoxide and hydroxyl radicals, in living cells.	Oxygen	130-137	spindlin 1	Homo sapiens	0-4
33030707-12	2021	The mean oxygen consumption (95% CI) for the usual and medium paces was 11.97 (11.69-12.25) and 13.34 (12.94-13.73) mL/kg/min, respectively.	Oxygen	9-15	thrombopoietin	Mus musculus	116-118
33256027-1	2020	Methemoglobin (MetHb) is a hemoglobin (Hb) derivative with the heme iron in ferric state (Fe3+), unable to deliver oxygen.	Oxygen	115-121	hemoglobin subunit gamma 2	Homo sapiens	0-13
33256027-1	2020	Methemoglobin (MetHb) is a hemoglobin (Hb) derivative with the heme iron in ferric state (Fe3+), unable to deliver oxygen.	Oxygen	115-121	hemoglobin subunit gamma 2	Homo sapiens	15-20
33174426-0	2020	Spin Polarization-Induced Facile Dioxygen Activation in Boron-Doped Graphitic Carbon Nitride.	Oxygen	33-41	spindlin 1	Homo sapiens	0-4
33174426-5	2020	It is revealed that the B atom can induce considerable spin polarization on B/g-C3N4, which accounts for O2 activation.	Oxygen	105-107	spindlin 1	Homo sapiens	55-59
33437471-0	2021	Effects of hyperbaric oxygen therapy on the healing of thermal burns and its relationship with ICAM-1: A case-control study.	Oxygen	22-28	intercellular adhesion molecule 1	Homo sapiens	95-101
33437471-2	2021	The purpose of our study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on the healing of thermal burns and its relationship with intercellular adhesion molecule 1 (ICAM-1).	Oxygen	70-76	intercellular adhesion molecule 1	Homo sapiens	150-183
33437471-2	2021	The purpose of our study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on the healing of thermal burns and its relationship with intercellular adhesion molecule 1 (ICAM-1).	Oxygen	70-76	intercellular adhesion molecule 1	Homo sapiens	185-191
33376328-0	2020	CD44-Targeting Oxygen Self-Sufficient Nanoparticles for Enhanced Photodynamic Therapy Against Malignant Melanoma.	Oxygen	15-21	CD44 antigen	Mus musculus	0-4
32976985-2	2020	Recent evidence suggests that hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor that regulates oxygen levels, plays a key role in neurological outcomes after ischemic stroke.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	30-61
19098915-4	2009	Additionally, four water molecules in combination with four backbone carbonyl oxygen atoms are seen to participate in K(+) and Rb(+) ion chelation, at both the external entrance and the vestibule of the NaK filter, confirming the channel"s preference for an octahedral ligand configuration for K(+) and Rb(+) binding.	Oxygen	78-84	TANK binding kinase 1	Homo sapiens	203-206
32976985-2	2020	Recent evidence suggests that hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor that regulates oxygen levels, plays a key role in neurological outcomes after ischemic stroke.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	63-73
33174947-3	2020	The present study aimed to analyze the effects of different levels of physical activity, classified by the Maximal oxygen consumption (VO2 max) values, on the telomere length of memory Cluster of differentiation (CD) CD4+(CD45ROneg and CD45RO+), effector CD8+CD28neg, and CD8+CD28+ T cells in aged individuals.	Oxygen	115-121	protein tyrosine phosphatase receptor type C	Homo sapiens	222-231
33174947-3	2020	The present study aimed to analyze the effects of different levels of physical activity, classified by the Maximal oxygen consumption (VO2 max) values, on the telomere length of memory Cluster of differentiation (CD) CD4+(CD45ROneg and CD45RO+), effector CD8+CD28neg, and CD8+CD28+ T cells in aged individuals.	Oxygen	115-121	protein tyrosine phosphatase receptor type C	Homo sapiens	222-228
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	nitric oxide synthase 3	Rattus norvegicus	315-319
33362540-10	2020	Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.	Oxygen	0-6	intercellular adhesion molecule 1	Rattus norvegicus	385-391
33321687-0	2020	Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y Cells.	Oxygen	84-90	apoptosis inducing factor mitochondria associated 1	Homo sapiens	64-67
33074043-1	2021	Sodium nitrite is a powerful oxidizing agent that causes hypotension and limits oxygen transport and delivery in the body through the formation of methemoglobin.	Oxygen	80-86	hemoglobin subunit gamma 2	Homo sapiens	147-160
18978072-3	2009	Enhanced oxygen consumption and applications of inhibitors of alternative mitochondrial and chloroplast oxidases (AOX and PTOX) suggest that chlororespiration as well as mitochondrial respiration are involved in the enhanced plastoquinone reduction state in the dark.	Oxygen	9-15	Alternative oxidase family protein	Arabidopsis thaliana	122-126
33153000-5	2020	Xanthine oxidase (XO) is an enzyme that utilizes molecular oxygen and produces reactive oxygen species (ROS).	Oxygen	59-65	xanthine dehydrogenase	Mus musculus	0-16
33273633-7	2020	We further demonstrate mitochondrial damage, impaired oxygen consumption and the reduction of the intestinal ATP content in Muc2 knockout mice.	Oxygen	54-60	mucin 2	Mus musculus	124-128
19149670-3	2009	We have previously shown that O2( -) and H2O2/HOCl are physiologically relevant inactivators of alpha 2M, a key anti-proteinase.	Oxygen	30-32	alpha-2-macroglobulin	Homo sapiens	96-104
33171408-3	2020	The docking studies suggest that 17 tightly binds to the Zn(II) of VIM-2 and CphA by the oxygen atoms of sulfonamide group, but coordinates with the Zn(II) of L1 through the oxygen atoms of hydroxamic acid group.	Oxygen	89-95	vimentin 2, pseudogene	Homo sapiens	67-72
33075501-3	2020	In the lungs, endurance training raised the expression level of the oxygen sensors hypoxia inducible factor 1alpha (HIF1alpha) and lysine-specific demethylase 6A (KDM6A) as well as stimulated mitochondrial oxidative capacity and mitochondrial biogenesis, while lactate dehydrogenase activity was reduced.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	83-114
33153072-0	2020	Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D. Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most severe diseases worldwide.	Oxygen	122-128	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	0-21
33425312-4	2020	Oxygen transfer rates of about 15% of the nominal 250 ml (STP)/min of a typical adult oxygen consumption rate were achieved for blood flow rates of 500 ml/min.	Oxygen	0-6	thyroid hormone receptor interactor 10	Homo sapiens	58-61
33075501-3	2020	In the lungs, endurance training raised the expression level of the oxygen sensors hypoxia inducible factor 1alpha (HIF1alpha) and lysine-specific demethylase 6A (KDM6A) as well as stimulated mitochondrial oxidative capacity and mitochondrial biogenesis, while lactate dehydrogenase activity was reduced.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	116-125
19082433-5	2008	UCP3 upregulation increased mitochondrial uncoupling respiration thus reducing O2(.-) generation, but inevitably decreased ATP production.	Oxygen	79-81	uncoupling protein 3	Rattus norvegicus	0-4
33075501-3	2020	In the lungs, endurance training raised the expression level of the oxygen sensors hypoxia inducible factor 1alpha (HIF1alpha) and lysine-specific demethylase 6A (KDM6A) as well as stimulated mitochondrial oxidative capacity and mitochondrial biogenesis, while lactate dehydrogenase activity was reduced.	Oxygen	68-74	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	Rattus norvegicus	131-161
32346884-2	2020	Endocan inhibition has previously been reported to suppress RNV in oxygen-induced retinopathy (OIR); however, its molecular mechanisms remain to be elucidated.	Oxygen	67-73	endothelial cell specific molecule 1	Homo sapiens	0-7
31760586-18	2020	This preliminary study found that CPAP via a tight-fitting mask may be an effective tool to reduce the incidence and duration of obstructive apneic events as well as hemoglobin oxygen desaturation during lower endoscopy procedures that use propofol and fentanyl for sedation.Clinical Trial Registration ClinicalTrials.gov ID: NCT02623270.	Oxygen	177-183	centromere protein J	Homo sapiens	34-38
32035229-3	2020	beta-Carotene 15,15"-dioxygenase (BCO1) catalyzes the oxidative cleavage of the central 15,15" carbon-carbon double of beta-carotene bond by addition of molecular oxygen.	Oxygen	23-29	beta-carotene oxygenase 1	Homo sapiens	34-38
33037620-3	2020	Calculated oxygen tension at half-saturation (p50 ) was on average (+-SD) 3 3 (3 13) mmHg lower than the normal p50 value (23 4 vs. 26 7 mmHg; P < 0 0001).	Oxygen	11-17	activating signal cointegrator 1 complex subunit 1	Homo sapiens	46-49
32043174-0	2020	Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats.	Oxygen	22-39	dynamin 1-like	Rattus norvegicus	101-105
32043174-0	2020	Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats.	Oxygen	22-39	protein kinase C, gamma	Rattus norvegicus	118-121
33097573-6	2020	In addition, we found that the rapid reductions in oxygen tension in a culture atmosphere triggered the degranulation of BMCMCs derived from wild-type TRPA1-expressing mice but not that of BMCMCs derived from TRPA1-deficient mice.	Oxygen	51-57	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	151-156
32841410-0	2020	Spin-inversion mechanisms in O2 binding to a model heme compound: A perspective from nonadiabatic wave packet calculations.	Oxygen	29-31	spindlin 1	Homo sapiens	0-4
18708172-2	2008	Hypoxia inducible factor-1alpha (HIF-1alpha) controls the expression of several genes that increase physiological O2 supply.	Oxygen	114-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
32841410-1	2020	Spin-inversion dynamics in O2 binding to a model heme complex, which consisted of Fe(II)-porphyrin and imidazole, were studied using nonadiabatic wave packet dynamics calculations.	Oxygen	27-29	spindlin 1	Homo sapiens	0-4
32705332-0	2020	Correction to: Reduced nNOS activity is responsible for impaired fatty acid-dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat.	Oxygen	100-106	nitric oxide synthase 1	Rattus norvegicus	23-27
32978274-7	2020	When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation was increased.	Oxygen	78-84	stearoyl-Coenzyme A desaturase 1	Mus musculus	5-9
18708172-2	2008	Hypoxia inducible factor-1alpha (HIF-1alpha) controls the expression of several genes that increase physiological O2 supply.	Oxygen	114-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
33035578-4	2020	MAIN METHODS: TRPA1 role was evaluated from inflammatory (ear edema, myeloperoxidase, and N-acetyl-beta-D-glycosaminidase activities, histological changes, and cytokines levels), proliferative (epidermal hyperplasia, PCNA, and TRPA1 levels), and oxidative (reactive oxygen intermediates measure and NADPH oxidase activity) parameters caused by UVB radiation single (0.5 J/cm2) or repeated (0.1 J/cm2) exposure.	Oxygen	266-272	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	14-19
18708172-4	2008	Other O2-sensitive transcription factors such as HIF-2alpha may be important for VAH by reducing metabolic O2 demands also.	Oxygen	6-8	endothelial PAS domain protein 1	Mus musculus	49-59
19006282-6	2008	For both systems, Co+-lysine and Co2+-lysine, the most stable structure results from the interaction of neutral lysine to the metal cation through the two amino groups and the carbonyl oxygen, the ground electronic state being a 3A in the case of Co+ and 4A for the Co2+ system.	Oxygen	185-191	complement C2	Homo sapiens	33-36
32002742-8	2020	In the unadjusted analysis, both ALT and GGT were positively correlated with AHI, oxygen desaturation index, percentage of total sleep time spent with oxyhemoglobin saturation below 90%, male sex, homeostasis model assessment of insulin resistance (HOMA-IR), and total cholesterol, while liver enzymes were negatively related to lowest oxygen saturation.	Oxygen	82-88	inactive glutathione hydrolase 2	Homo sapiens	41-44
32002742-8	2020	In the unadjusted analysis, both ALT and GGT were positively correlated with AHI, oxygen desaturation index, percentage of total sleep time spent with oxyhemoglobin saturation below 90%, male sex, homeostasis model assessment of insulin resistance (HOMA-IR), and total cholesterol, while liver enzymes were negatively related to lowest oxygen saturation.	Oxygen	336-342	inactive glutathione hydrolase 2	Homo sapiens	41-44
33457246-1	2020	Background: Glutathione peroxidase-1 (GPX1) is generally expressed in tissues with high oxygen tension such as the kidneys and lungs, and its main function is to degrade reactive oxygen species (ROS) and protect cells from oxidative stress.	Oxygen	88-94	glutathione peroxidase 1	Homo sapiens	12-36
33457246-1	2020	Background: Glutathione peroxidase-1 (GPX1) is generally expressed in tissues with high oxygen tension such as the kidneys and lungs, and its main function is to degrade reactive oxygen species (ROS) and protect cells from oxidative stress.	Oxygen	88-94	glutathione peroxidase 1	Homo sapiens	38-42
33265962-0	2020	Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation.	Oxygen	102-108	death associated protein kinase 1	Rattus norvegicus	62-67
33247423-8	2020	Additionally, the oxygen generating scaffolds improved revascularization as observed through vWF immunostaining.	Oxygen	18-24	von Willebrand factor	Rattus norvegicus	93-96
33262598-0	2020	Long Non-Coding RNA SNHG7 Alleviates Oxygen and Glucose Deprivation/Reoxygenation-Induced Neuronal Injury by Modulating miR-9/SIRT1 Axis in PC12 Cells: Potential Role in Ischemic Stroke.	Oxygen	37-43	small nucleolar RNA host gene 7	Mus musculus	20-25
33205494-2	2021	Although it is thought that TSPO plays key roles in a multitude of host cell functions, including steroid biosynthesis, apoptosis, generation of reactive oxygen species, and proliferation, some of these functions have recently been questioned.	Oxygen	154-160	translocator protein	Homo sapiens	28-32
33170927-10	2021	CONCLUSION: Children less than 1 year of age hospitalized with SARS-CoV-2 in Cape Town frequently required respiratory support, the access to oxygen may be limited in some LMICs which could potentially drive morbidity and mortality.	Oxygen	142-148	structural maintenance of chromosomes 2	Homo sapiens	77-81
32859750-4	2020	To help address this problem, we developed a computational model to analyze and identify the kinetic mechanism of O2 .- and H2O2 production by SDH.	Oxygen	114-116	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	143-146
33171970-6	2020	Oxygen Radical Absorbance assay, Superoxide Dismutase activity and Glutathione Peroxidase (GPx) assays indicated the antioxidant properties of the chrysin complexes.	Oxygen	0-6	chromate resistance; sulfate transport	Homo sapiens	147-154
32836058-6	2020	Meanwhile, APAP was released at acidic tumor environment and subsequently activated by overexpressed tyrosinase in the presence of O2 to produce cytotoxic benzoquinone metabolites (AOBQ).	Oxygen	131-133	tyrosinase	Homo sapiens	101-111
32599385-6	2020	Characterization using various techniques such as XRD, TEM, BET, XPS, H2-TPR and CO2-TPD showed that Co3+ and surface adsorbed oxygen (Osur) enriched surface, excellent redox properties and effective diffusion of the reaction product reasonably explain the enhancement in catalytic activity over the E--NiCo2O4.	Oxygen	127-133	translocated promoter region, nuclear basket protein	Homo sapiens	73-76
33218451-3	2020	It is suggested that putative NADPH oxidase in the outer membrane oxidizes intracellular NADPH to produce O2- and secrete it externally.	Oxygen	106-109	2,4-dienoyl-CoA reductase 1	Homo sapiens	30-35
33218451-4	2020	Earlier studies revealed that photosynthetic electron transport, a major producer of NADPH in photosynthetic organisms, is involved in the production of O2- in C. antiqua but the details of the O2- production mechanism have yet to be elucidated.	Oxygen	153-156	2,4-dienoyl-CoA reductase 1	Homo sapiens	85-90
33218451-4	2020	Earlier studies revealed that photosynthetic electron transport, a major producer of NADPH in photosynthetic organisms, is involved in the production of O2- in C. antiqua but the details of the O2- production mechanism have yet to be elucidated.	Oxygen	194-197	2,4-dienoyl-CoA reductase 1	Homo sapiens	85-90
33218451-10	2020	These observations suggest that another metabolic pathway, independent of photosynthesis, provides NADPH for the production of O2- under nutrient deficiency.	Oxygen	127-130	2,4-dienoyl-CoA reductase 1	Homo sapiens	99-104
33070285-3	2020	The center of energy regulation in human is AMP-activated protein kinase (AMPK), which modulates cells" metabolic pathways and protects them against negative effects of metabolic stress, e.g. reactive oxygen species.	Oxygen	201-207	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	44-72
33070285-3	2020	The center of energy regulation in human is AMP-activated protein kinase (AMPK), which modulates cells" metabolic pathways and protects them against negative effects of metabolic stress, e.g. reactive oxygen species.	Oxygen	201-207	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	74-78
33192319-10	2020	Our data show increased claudin-5 and occludin expression in oxygen and glucose (OGD)-deprived murine brain capillary cerebellar endothelial cells (cerebEND) after STVNa treatment.	Oxygen	61-67	claudin 5	Mus musculus	24-33
33192579-11	2020	These data clearly show that TRPA1 is necessary for multiple mild hypoxia (13-15% O2)-induced physiological responses.	Oxygen	82-84	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	29-34
32791151-10	2020	Hyperbaric oxygen promoted the proliferation, migration and ROS production, as well as the expression of SDF-1 and VEGFA in HSF.	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	115-120
33066332-1	2020	Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway.	Oxygen	190-196	solute carrier family 2 member 1	Homo sapiens	141-162
33066332-1	2020	Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway.	Oxygen	190-196	solute carrier family 2 member 1	Homo sapiens	164-170
32975930-0	2020	Controlled Natural Biomass Deoxygenation Allows the Design of Reusable Hot-Melt Adhesives Acting in a Multiple Oxygen Binding Mode.	Oxygen	111-117	alcohol dehydrogenase iron containing 1	Homo sapiens	71-74
32877602-4	2020	The results of XPS, Raman, H2-TPR, and DFT calculation all prove that the (310) facets possess the higher surface energy than other facets can feature the construction of oxygen vacancies, thus facilitating the adsorption and activate O3 into intermediate peroxide species (O2-/O22-) and reactive oxygen species ( O2-/1O2) for eliminating adjacent CH3SH.	Oxygen	171-177	translocated promoter region, nuclear basket protein	Homo sapiens	30-33
32877602-4	2020	The results of XPS, Raman, H2-TPR, and DFT calculation all prove that the (310) facets possess the higher surface energy than other facets can feature the construction of oxygen vacancies, thus facilitating the adsorption and activate O3 into intermediate peroxide species (O2-/O22-) and reactive oxygen species ( O2-/1O2) for eliminating adjacent CH3SH.	Oxygen	274-276	translocated promoter region, nuclear basket protein	Homo sapiens	30-33
32877602-4	2020	The results of XPS, Raman, H2-TPR, and DFT calculation all prove that the (310) facets possess the higher surface energy than other facets can feature the construction of oxygen vacancies, thus facilitating the adsorption and activate O3 into intermediate peroxide species (O2-/O22-) and reactive oxygen species ( O2-/1O2) for eliminating adjacent CH3SH.	Oxygen	278-280	translocated promoter region, nuclear basket protein	Homo sapiens	30-33
33023658-6	2020	Additionally, glucose clearance and oxygen consumption were upregulated in Arid5b-/- mice.	Oxygen	36-42	AT rich interactive domain 5B (MRF1-like)	Mus musculus	75-81
33083461-0	2020	Ambra1 Alleviates Hypoxia/Reoxygenation Injury in H9C2 Cells by Regulating Autophagy and Reactive Oxygen Species.	Oxygen	98-104	autophagy and beclin 1 regulator 1	Rattus norvegicus	0-6
32786677-10	2020	On the contrary, WT A1CF affected the expression of mitochondrial matrix proteins and increased cell oxygen consumption.	Oxygen	101-107	APOBEC1 complementation factor	Homo sapiens	20-24
32813542-0	2020	3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway.	Oxygen	98-104	mercaptopyruvate sulfurtransferase	Rattus norvegicus	0-36
32565080-0	2020	Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase.	Oxygen	74-80	acyl-CoA oxidase 1	Homo sapiens	111-130
32565080-10	2020	SIGNIFICANCE: The alternative oxidase is a ubiquinol oxidoreductase enzyme that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	Oxygen	138-144	acyl-CoA oxidase 1	Homo sapiens	18-37
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Oxygen	113-115	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Oxygen	174-176	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
33193403-0	2020	The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen Carriers.	Oxygen	111-117	HGB	Sus scrofa	94-104
33113858-2	2020	Several mechanisms regulate the cellular response to oxygen including the prolyl hydroxylase domain (PHD)/factor inhibiting HIF (FIH)-hypoxia inducible factor (HIF) pathway, cysteamine (2-aminoethanethiol) dioxygenase (ADO) system, and the lysine-specific demethylases (KDM) 5A and KDM6A.	Oxygen	53-59	lysine demethylase 5A	Homo sapiens	240-277
33105790-4	2020	The surface tension of C12EO6 in 2Cn(Spacer) NTf2 with oxygen-containing spacers increased with increasing concentration of C12EO6, becoming close to that of C12EO6 alone, indicating that the amphiphilic ionic liquid adsorbed at the interface was replaced with CxEO6.	Oxygen	55-61	nuclear transport factor 2	Homo sapiens	45-49
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	kinase insert domain receptor	Homo sapiens	193-198
32791151-12	2020	CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS.	Oxygen	23-29	chemokine (C-X-C motif) receptor 4	Mus musculus	199-204
33056981-5	2020	COSMIC mutational signature 18, previously associated with reactive oxygen species, is the most common cause of driver point mutations in neuroblastoma, including most ALK and Ras-activating variants.	Oxygen	68-74	ALK receptor tyrosine kinase	Homo sapiens	168-171
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	55-57	serine and arginine rich splicing factor 1	Homo sapiens	62-65
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	55-57	serine and arginine rich splicing factor 1	Homo sapiens	168-171
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	95-97	serine and arginine rich splicing factor 1	Homo sapiens	62-65
33110979-7	2020	Furthermore, the reactivity order of various groups to O2 is (SF2)* > (SF3)* > (SF4)* > F*, so O2 is more likely to participate in the reaction by attacking (SF3)* or (SF2)* groups.	Oxygen	95-97	serine and arginine rich splicing factor 1	Homo sapiens	168-171
32778319-4	2020	The MBR behavior was monitored over seven months for different parameters (pH, temperature, permeate flow, transmembrane pressure, biological oxygen demand-BOD5, chemical oxygen demand-COD, total organic carbon-TOC, solids, and SDZ concentration).	Oxygen	142-148	translocator protein	Homo sapiens	4-7
32778319-4	2020	The MBR behavior was monitored over seven months for different parameters (pH, temperature, permeate flow, transmembrane pressure, biological oxygen demand-BOD5, chemical oxygen demand-COD, total organic carbon-TOC, solids, and SDZ concentration).	Oxygen	171-177	translocator protein	Homo sapiens	4-7
32562333-0	2020	The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides.	Oxygen	80-86	Gpb1p	Saccharomyces cerevisiae S288C	42-46
32562333-3	2020	gpb1 deletion mutation analysis revealed its relevance for an adequate development during the dimorphic transition and for hyphal growth under low oxygen concentrations.	Oxygen	147-153	Gpb1p	Saccharomyces cerevisiae S288C	0-4
32562333-9	2020	These findings reveal that M. circinelloides possesses a signal transduction pathway through which the Gpb1 heterotrimeric G subunit and PkaR1 control mycelial growth in response to low oxygen levels.	Oxygen	186-192	Gpb1p	Saccharomyces cerevisiae S288C	103-107
19076451-9	2008	Erv1 directly interacts with Mia40 and shuttles electrons from reduced Mia40 to oxidized cytochrome c, from whence they flow through cytochrome oxidase to molecular oxygen.	Oxygen	165-171	growth factor, augmenter of liver regeneration	Homo sapiens	0-4
32823072-0	2020	Transient pockets as mediators of gas molecules routes inside proteins: The case study of dioxygen pathway in homogentisate 1,2-dioxygenase and its implication in Alkaptonuria development.	Oxygen	90-98	homogentisate 1,2-dioxygenase	Homo sapiens	110-139
19076451-11	2008	The oxidative activity of Erv1 strongly depends on the oxygen concentration in mitochondria.	Oxygen	55-61	growth factor, augmenter of liver regeneration	Homo sapiens	26-30
19076451-12	2008	Erv1, therefore, may function as a molecular switch that adapts mitochondrial activities to the oxygen levels in the cell.	Oxygen	96-102	growth factor, augmenter of liver regeneration	Homo sapiens	0-4
32745469-0	2020	miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN.	Oxygen	55-61	microRNA 188	Homo sapiens	0-7
18301921-2	2008	The enzyme heme oxygenase-1 (HO-1) participates in cytoprotection against oxygen radical injury.	Oxygen	16-22	heme oxygenase 1	Homo sapiens	29-33
32115713-4	2020	Severe hypoxia (0.1% O2 ) induced the processing of pro-IL-1beta, pro-caspase-1, and gasdermin D, as well as the release of IL-1beta and lactate dehydrogenase in lipopolysaccharide (LPS)-primed murine macrophages, indicating that hypoxia induces NLRP3 inflammasome-driven inflammation and pyroptosis.	Oxygen	21-23	gasdermin D	Mus musculus	85-96
32251255-4	2020	PURPOSE: Newly designed albumin-derived perfluorocarbon-based artificial oxygen carriers (A-AOCs) are used in a rodent in-vivo model as a preventive therapy for decompression sickness (DCS).	Oxygen	73-79	albumin	Rattus norvegicus	24-31
18842302-3	2008	In this reactivity comparison, the reactivities of metal-peroxo species were found to be in the order of [MnIII(TMC)(O2)]+ &gt; [CoIII(TMC)(O2)]+ &gt; [FeIII(TMC)(O2)]+.	Oxygen	117-119	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	112-115
32945382-10	2020	The expression levels of hypoxia-inducible factor 1-alpha and NLRP3 increased after oxygen and glucose deprivation (OGD), and reduced after treatment with OGD and TMP (all P<0.05).	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	25-57
32747794-6	2020	We show that MTAP loss upregulates polyamine metabolism which, concurrently with cysteine withdrawal, promotes elevated reactive oxygen species and prevents cell survival.	Oxygen	129-135	methylthioadenosine phosphorylase	Homo sapiens	13-17
32949969-12	2020	As redox and other intracellular signaling pathways are critically affected by O2, the development of antioxidant therapies targeting the Keap1-Nrf2 defense pathway in treatment of ischemia-reperfusion injury in stroke, coronary and renal disease will require in vitro studies conducted under well-defined O2 levels.	Oxygen	79-81	kelch-like ECH-associated protein 1	Mus musculus	138-143
32949969-12	2020	As redox and other intracellular signaling pathways are critically affected by O2, the development of antioxidant therapies targeting the Keap1-Nrf2 defense pathway in treatment of ischemia-reperfusion injury in stroke, coronary and renal disease will require in vitro studies conducted under well-defined O2 levels.	Oxygen	306-308	kelch-like ECH-associated protein 1	Mus musculus	138-143
32975211-0	2020	Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.	Oxygen	176-182	peroxiredoxin 3	Homo sapiens	0-15
18797451-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key regulator of the response to low oxygen levels and has been used for therapeutic angiogenesis.	Oxygen	87-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
33003371-2	2020	Exposure to 1-5% oxygen increased the levels of CI in both RISP and COX10 KO fibroblasts.	Oxygen	17-23	heme A:farnesyltransferase cytochrome c oxidase assembly factor 10	Mus musculus	68-73
33003371-7	2020	Exposure to low oxygen levels stabilized HIF-1alpha and increased CI levels in RISP and COX10 KO fibroblasts.	Oxygen	16-22	heme A:farnesyltransferase cytochrome c oxidase assembly factor 10	Mus musculus	88-93
32992843-5	2020	We found: (i) In SP-A2 mice, the redox alteration of AM in response to O3 showed sex-dependence with AM from males being significantly more oxidized and having a higher level of mitochondrial reactive oxygen species than females; (ii) AM from KO mice were more oxidized after O3 exposure and showed no sex differences; (iii) AM from female KO mice were more oxidized than female SP-A2 mice; and (iv) Two distinct subpopulations characterized by size and redox status were observed in a mouse AM sample.	Oxygen	201-207	sperm head anomaly 2	Mus musculus	17-22
32683093-6	2020	Interestingly, enhancement of CoQ9/10 levels with the lowest dose of palmitate (0.15 mM) was accompanied by a significantly reduction of CoQ9 oxidation status, as well as low cytosolic production of reactive oxygen species.	Oxygen	208-214	coenzyme Q9	Homo sapiens	30-37
32683093-6	2020	Interestingly, enhancement of CoQ9/10 levels with the lowest dose of palmitate (0.15 mM) was accompanied by a significantly reduction of CoQ9 oxidation status, as well as low cytosolic production of reactive oxygen species.	Oxygen	208-214	coenzyme Q9	Homo sapiens	30-34
31997156-6	2020	MAP4K4 was suggested to be methylated in an in vitro model of oxygen-glucose deprivation (OGD)-treated mouse primary cortical neurons, while its overexpression could inhibit OGD-induced neuronal apoptosis.	Oxygen	62-76	mitogen-activated protein kinase kinase kinase kinase 4	Mus musculus	0-6
18797451-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key regulator of the response to low oxygen levels and has been used for therapeutic angiogenesis.	Oxygen	87-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
28189008-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key regulator of the response to low oxygen levels and has been used for therapeutic angiogenesis.	Oxygen	87-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
32993479-7	2020	RESULTS: The fraction of inspired oxygen requirements was reduced for all five patients after initiating dornase alfa administration.	Oxygen	34-40	deoxyribonuclease 1	Homo sapiens	105-117
32353730-3	2020	The removal efficiency of SMR and TOC was 73.91 % and 56.80 %, respectively at initial pH = 5.8, T = 20  C, O2 flow rate = 100 mL/min, Al -CNTs-Cu2O dosage = 2 g/L, SMR = 50 mg/L, and reaction time = 60 min.	Oxygen	108-110	LY6/PLAUR domain containing 4	Homo sapiens	26-29
33042135-6	2020	We find that scaffolding LSD1 inhibitors potently reduce oxidative phosphorylation and glycolysis of NK cells, and higher doses induce mitochondrial reactive oxygen species and depletion of the antioxidant glutathione.	Oxygen	158-164	lysine demethylase 1A	Homo sapiens	25-29
33089077-6	2020	Furthermore, in oxygen-induced retinopathy (OIR) mice, the absence of Fpr2 was associated with diminished neovasculature formation and pathological vaso-obliteration region in the retina.	Oxygen	16-22	formyl peptide receptor 2	Mus musculus	70-74
28189008-1	2008	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key regulator of the response to low oxygen levels and has been used for therapeutic angiogenesis.	Oxygen	87-93	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
18801745-5	2008	Hypoxia-inducible factor 1alpha (HIF1alpha) is the primary transcription factor that is responsible for regulating the cellular response to changes in oxygen tension and is essential for normal development.	Oxygen	151-157	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
32787085-3	2020	Herein, we report that the replacement of a methylene unit of the adamantane group by an oxygen atom increases the solubility, permeability and stability of three series of urea-based sEH inhibitors.	Oxygen	89-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	184-187
32822191-2	2020	Importantly, a Cu-mediated remote C-H hydroxylation reaction has been developed to site-selectively install the oxygen function at the C-7 position of the target molecules, thus solving the biggest challenge for the synthesis of the compounds.	Oxygen	112-118	complement C7	Homo sapiens	135-138
32899780-0	2020	Spinel of Nickel-Cobalt Oxide with Rod-Like Architecture as Electrocatalyst for Oxygen Evolution Reaction.	Oxygen	80-86	kinetochore associated 1	Homo sapiens	35-38
18801745-5	2008	Hypoxia-inducible factor 1alpha (HIF1alpha) is the primary transcription factor that is responsible for regulating the cellular response to changes in oxygen tension and is essential for normal development.	Oxygen	151-157	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-42
32413797-4	2020	The results confirmed that CGW was degraded effectively and that the chemical oxygen demand (COD) was reduced from 1057 to 362 mgL-1, utilizing 50 mgL-1 ozone for 90 min.	Oxygen	78-84	LLGL scribble cell polarity complex component 1	Homo sapiens	127-132
19067366-10	2008	Furthermore, brain proteome changes after a single systemic rEpo treatment point toward a number of mechanisms through which rEpo may generate its protective effect against oxygen toxicity.	Oxygen	173-179	erythropoietin	Rattus norvegicus	60-64
32413797-4	2020	The results confirmed that CGW was degraded effectively and that the chemical oxygen demand (COD) was reduced from 1057 to 362 mgL-1, utilizing 50 mgL-1 ozone for 90 min.	Oxygen	78-84	LLGL scribble cell polarity complex component 1	Homo sapiens	147-152
32716567-4	2020	Here, we investigated the inhibition of FECH using genetic and chemical approaches in the oxygen-induced retinopathy (OIR) mouse model.	Oxygen	90-96	ferrochelatase	Mus musculus	40-44
32984400-5	2020	Proteolytic knockdown of GPX1 is highly consistent with previously documented effects of recombinant SARS-CoV Mpro in transfected cells, including increased reactive oxygen species and NF-kappaB activation.	Oxygen	166-172	glutathione peroxidase 1	Homo sapiens	25-29
32912004-3	2020	Microsomal enzymes generate H2O2 as a consequence of electron transfer from NADPH to cytochrome P450 hemoproteins with subsequent oxygen activation.	Oxygen	130-136	2,4-dienoyl-CoA reductase 1	Homo sapiens	76-81
19067366-10	2008	Furthermore, brain proteome changes after a single systemic rEpo treatment point toward a number of mechanisms through which rEpo may generate its protective effect against oxygen toxicity.	Oxygen	173-179	erythropoietin	Rattus norvegicus	125-129
18778796-2	2008	In this context, particular attention is given to the reactions of small molecules such as dioxygen, carbon monoxide, and nitric oxide with selected hemoproteins (hemoglobin, myoglobin, neuroglobin and cytochrome P450(cam)), as well as to photo-induced electron transfer reactions occurring in hemoproteins (particularly in various types of cytochromes).	Oxygen	91-99	myoglobin	Homo sapiens	175-184
32329533-2	2020	The higher catalytic performance in an oxygen reduction reaction (ORR) was achieved by anti -Me 2 P with higher turnover number (TON = 250 for 30 min) than that by syn -Me 2 P (TON = 218 for 60 min).	Oxygen	39-45	synemin	Homo sapiens	164-167
32350615-8	2020	These results suggested that the loss of the cortical and trabecular bone is inhibited by mild hyperbaric oxygen, because of an inhibition of osteoclasts and enhancement of bone formation with decreased Sost expression.	Oxygen	106-112	sclerostin	Rattus norvegicus	203-207
18832935-6	2008	Results suggest that whereas RhAG has a channel for passage of neutral gases (CO2, NH3 and possibly oxygen and nitric oxide), D and CE polypeptides are unlikely to have a transport function.	Oxygen	100-106	Rh associated glycoprotein	Homo sapiens	29-33
32791328-2	2020	By genetic screening, we found that NADPH oxidases (Nox and Duox) associated with superoxide anion (O -2) are responsible for caspase-3 activation and delamination.	Oxygen	100-104	Death executioner caspase related to Apopain/Yama	Drosophila melanogaster	126-135
32791328-7	2020	These findings suggest that the roles of O -2 and intracellular H2O2 for delamination differs before and after caspase-3 activation, which involves live cell delamination.	Oxygen	41-45	Death executioner caspase related to Apopain/Yama	Drosophila melanogaster	111-120
32875124-1	2020	Superoxide dismutases, which catalytically remove intracellular superoxide radicals by the disproportionation of molecular oxygen and hydrogen peroxide, are encoded by the sod-1 to -5 genes in the nematode C. elegans.	Oxygen	123-129	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	172-183
32807793-7	2020	Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.	Oxygen	72-78	oncostatin M receptor	Homo sapiens	12-16
32784646-2	2020	However, Msx1 can exert its tumor suppressive effect through the inhibition of angiogenesis since growth of the tumor relies on sufficient blood supply from the existing vessels to provide oxygen and nutrients for tumor growth.	Oxygen	189-195	msh homeobox 1	Mus musculus	9-13
32923413-0	2020	Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons.	Oxygen	36-42	sirtuin 1	Homo sapiens	0-5
32826883-9	2020	In conclusion, we have identified the nuclear lncRNA Neat1 as part of a conserved oxygen-sensitive feedback mechanism by regulation of miRNA processing and a potential target in cardioprotection.	Oxygen	82-88	nuclear paraspeckle assembly transcript 1	Homo sapiens	53-58
32788413-9	2020	Estimated maximal oxygen consumption was correlated with glutathione peroxidase 1 (r = .48; P < .05).	Oxygen	18-24	glutathione peroxidase 1	Homo sapiens	57-81
18521628-8	2008	Ventilated survivors with later bronchopulmonary dysplasia (BPD; oxygen requirement at T3, n = 7) had significantly higher CC16 at all times compared to nonventilated neonates.	Oxygen	65-71	secretoglobin family 1A member 1	Homo sapiens	123-127
32626926-5	2020	The results demonstrated that oxygen and glucose deprivation induced an increase in TXNIP expression, lactate dehydrogenase (LDH) release, caspase-3 activity, reactive oxygen species and malondialdehyde production.	Oxygen	30-36	thioredoxin interacting protein	Rattus norvegicus	84-89
32626926-7	2020	TXNIP overexpression reversed the effects of 3.5% sevoflurane preconditioning on caspase-3 activity, reactive oxygen production and cell viability.	Oxygen	110-116	thioredoxin interacting protein	Rattus norvegicus	0-5
32626926-8	2020	Furthermore, TXNIP modulated p27 expression via PKB (protein kinase B/AKT) phosphorylation following preconditioning with 3.5% sevoflurane, and oxygen and glucose deprivation.	Oxygen	144-150	thioredoxin interacting protein	Rattus norvegicus	13-18
32759274-5	2020	Knockout of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3; Pfkfb3 for rodents), a glycolytic activator in myeloid cells, impaired the ability of macrophages/microglia to acquire an angiogenic phenotype, rendering them unable to promote EC proliferation and sprouting and pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	339-345	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	67-73
32759274-5	2020	Knockout of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3; Pfkfb3 for rodents), a glycolytic activator in myeloid cells, impaired the ability of macrophages/microglia to acquire an angiogenic phenotype, rendering them unable to promote EC proliferation and sprouting and pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	339-345	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	75-81
18667485-2	2008	The chief mediator of the hypoxic response is hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1alpha.	Oxygen	89-95	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-126
32356371-0	2020	Copper-oxygen Dynamics in Tyrosinase Mechanism.	Oxygen	7-13	tyrosinase	Homo sapiens	26-36
32356371-1	2020	The dinuclear copper enzyme tyrosinase activates O2  to form a (mu-eta2:eta2-peroxido)dicopper(II) species, which hydroxylates phenols to catechols.	Oxygen	49-51	tyrosinase	Homo sapiens	28-38
32468054-0	2020	Protective effect of microRNA-340-5p against oxygen-glucose deprivation/reperfusion in PC12 cells through targeting neuronal differentiation 4.	Oxygen	45-51	neuronal differentiation 4	Rattus norvegicus	116-142
18853324-1	2008	PURPOSE: To investigate whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy.	Oxygen	228-234	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-55
31997812-0	2020	Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.	Oxygen	109-115	brain derived neurotrophic factor	Homo sapiens	0-33
32623664-5	2020	Moreover, beta-asarone pretreatment also activated nuclear factor 2 erythroid-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1), which was involved in quenching reactive oxygen to inhibit oxidative stress.	Oxygen	133-139	heme oxygenase 1	Rattus norvegicus	146-150
31690173-5	2020	Activation of autophagy by rapamycin or TFEB overexpression ameliorates Mn-induced mitochondrial respiratory dysfunction and reactive oxygen species (ROS) generation in astrocytes, suggesting a causal relation between autophagic failure and mitochondrial dysfunction in Mn toxicity.	Oxygen	134-140	transcription factor EB	Mus musculus	40-44
32468073-6	2020	In addition, decreased Klotho protein further led to activation of the reactive oxygen species-p38 mitogen-activated protein kinase signaling pathway, finally resulting in myocardial damage.	Oxygen	80-86	klotho	Mus musculus	23-29
32802036-3	2020	In the present study, we demonstrated that expressions of Shh, Ptch, and Gli-1 were significantly downregulated at 24 h following oxygen-glucose deprivation (OGD) injury in neurons in vitro, effects which were associated with increasing numbers of apoptotic cells and reactive oxygen species generation.	Oxygen	130-136	sonic hedgehog signaling molecule	Rattus norvegicus	58-61
18692496-6	2008	Marked up-regulation of heme oxygenase-1 (HO-1) was detected in both NRK and INS-1 cells when cultured in 3% oxygen.	Oxygen	29-35	insulin 1	Rattus norvegicus	77-82
32449967-8	2020	Hepcidin and ferroportin expressions were positively associated with placental non-heme iron reserve (P < 0.0001; P = 0.033), lipid peroxidation (P = 0.0060; P < 0.0001) and reactive oxygen species level (P = 0.0092; P = 0.0292).	Oxygen	183-189	hepcidin antimicrobial peptide	Sus scrofa	0-8
18700745-2	2008	The experiments were performed with fullerene (C60) as photosensitizer for the generation of (1)O2 in nonpolar solvents (toluene and CCl4).	Oxygen	93-98	C-C motif chemokine ligand 4	Homo sapiens	133-137
32152203-3	2020	SDHB-mutated PCPGs exhibit dysregulation in oxygen metabolic pathways, including pseudohypoxia and formation of reactive oxygen species (ROS), suggesting that targeting redox balance pathway could be a potential therapeutic approach.	Oxygen	44-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-4
32740581-8	2020	RESULTS: Hyperbaric oxygen therapy with 3 atm increased viability, proliferation, and CD34 expression and reduced the CD31/CD34/CD45 adipose-derived stem cell subset and endothelial progenitor cell population.	Oxygen	20-26	protein tyrosine phosphatase receptor type C	Homo sapiens	128-132
32628026-2	2020	Among the four possible conformers of this species, predicted by theory within the energy window of 3 kcal/mol, only the lowest-energy conformer, the syn-trans form was detected in a discharged jet of a 1,3-diiode-but-2-ene (either in Z- or E-conformation) and O2 mixture diluted in Ar.	Oxygen	261-263	synemin	Homo sapiens	150-153
32589018-3	2020	In view of the volatile-organic-compounds penetration, herein, we rationally demonstrate a dual-scale porous, photothermal/photocatalytic, flexible membrane for volatile-organic-compounds intercepting solar distillation, which is based on mesoporous oxygen vacancy-rich TiO2-x nanofibrous membrane (m-TiO2-x NFM).	Oxygen	250-256	neurofilament medium chain	Homo sapiens	308-311
31593983-10	2020	In addition, enforced expression of EVI1 also increased intracellular reactive oxygen species and ATG7 mRNA levels as well as autophagy activity, whereas the increase was attenuated after treatment with reactive oxygen species scavenger, suggesting the involvement of reactive oxygen species in EVI1-induced autophagy.	Oxygen	79-85	MDS1 and EVI1 complex locus	Homo sapiens	36-40
32583838-7	2020	Studies indicate that charge is totally transferred from cobalt oxide clusters to oxygen, which consists of spin-up charge transfer from oxygen to the clusters and spin-down charge transfer from the clusters to oxygen.	Oxygen	82-88	spindlin 1	Homo sapiens	108-112
19087714-3	2008	Stepwise multiple linear regression analysis was conducted to determine the correlation of plasma resistin level with body mass index (BMI), body fat percentage, waist to hip ratio (WHR), fasting blood glucose (FBG), blood lipid, AHI, and lowest arterial oxygen saturation (LSaO(2)).	Oxygen	255-261	resistin	Homo sapiens	98-106
32583838-7	2020	Studies indicate that charge is totally transferred from cobalt oxide clusters to oxygen, which consists of spin-up charge transfer from oxygen to the clusters and spin-down charge transfer from the clusters to oxygen.	Oxygen	82-88	spindlin 1	Homo sapiens	164-168
32583838-7	2020	Studies indicate that charge is totally transferred from cobalt oxide clusters to oxygen, which consists of spin-up charge transfer from oxygen to the clusters and spin-down charge transfer from the clusters to oxygen.	Oxygen	137-143	spindlin 1	Homo sapiens	108-112
32583838-7	2020	Studies indicate that charge is totally transferred from cobalt oxide clusters to oxygen, which consists of spin-up charge transfer from oxygen to the clusters and spin-down charge transfer from the clusters to oxygen.	Oxygen	137-143	spindlin 1	Homo sapiens	108-112
32995127-0	2020	Porous Pt Nanospheres Incorporated with GOx to Enable Synergistic Oxygen-Inductive Starvation/Electrodynamic Tumor Therapy.	Oxygen	66-72	hydroxyacid oxidase 1	Homo sapiens	40-43
32995127-2	2020	However, this reaction of catalytic oxidation by GOx is highly dependent on the on-site oxygen content, and thus starvation therapy often suffers unexpected anticancer outcomes due to the intrinsic tumorous hypoxia.	Oxygen	88-94	hydroxyacid oxidase 1	Homo sapiens	49-52
32995127-4	2020	In this system, GOx can effectively catalyze the oxidation of glucose to generate H2O2, while pPt triggers the decomposition of both endogenous and exogenous H2O2 to produce considerable content of O2 to facilitate the glucose consumption by GOx.	Oxygen	84-86	hydroxyacid oxidase 1	Homo sapiens	16-19
32874480-2	2020	The aim of this study was to identify the effect of different doses of hyperbaric oxygen (HBO) exposure in reducing inflammation on ACIA through analysis hypoxia inducible factor-1alpha (HIF-1alpha), anticyclic citrullinated peptide antibody (ACPA) and interleukine 17a (IL-17a).	Oxygen	82-88	interleukin 17A	Mus musculus	271-277
32443232-7	2020	High PEC performance with TCNC NRAs electrode could be attributed to the enhanced charge separation and the change of electron transfer mechanism from typical heterojunction to Z-scheme, which may increase the active species production and change the dominant reactive species from O2 - to  OH.	Oxygen	282-286	NRAS proto-oncogene, GTPase	Homo sapiens	31-35
18479206-6	2008	However, a different role of the oxygen species produced by these sources is apparent as oxidants derived from NADPH oxidase are involved mainly in signaling processes, whereas those produced by mitochondria induce cell death in pathways including also the thioredoxin system, presently considered an important target for cancer chemotherapy.	Oxygen	33-39	thioredoxin	Homo sapiens	257-268
32617047-7	2020	The expression levels of catalase and SOD2 increased significantly after treatment with ginsenoside Mc1, resulting in a decrease in the production of H2O2-mediated reactive oxygen species.	Oxygen	173-179	superoxide dismutase 2	Rattus norvegicus	38-42
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Oxygen	53-59	aurora kinase B	Homo sapiens	128-133
32272228-2	2020	We have recently shown that the osteocyte responds to fluid shear stress via the microtubule network-dependent activation of NADPH oxidase 2 (NOX2)-generated reactive oxygen species and subsequent opening of TRPV4 cation channels, leading to calcium influx, activation of CaMKII, and rapid sclerostin protein downregulation.	Oxygen	167-173	cytochrome b-245 beta chain	Homo sapiens	125-140
32272228-2	2020	We have recently shown that the osteocyte responds to fluid shear stress via the microtubule network-dependent activation of NADPH oxidase 2 (NOX2)-generated reactive oxygen species and subsequent opening of TRPV4 cation channels, leading to calcium influx, activation of CaMKII, and rapid sclerostin protein downregulation.	Oxygen	167-173	cytochrome b-245 beta chain	Homo sapiens	142-146
18713979-0	2008	Tumor-educated tolerogenic dendritic cells induce CD3epsilon down-regulation and apoptosis of T cells through oxygen-dependent pathways.	Oxygen	110-116	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	50-60
31953914-0	2020	TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.	Oxygen	161-167	TNF receptor superfamily member 1B	Homo sapiens	5-10
32884432-4	2020	SNAP23 and its partner SNAREs mediate fusion of the plasma membrane with intracellular organelles or vesicles to form phagosomes as well as the fusion of phagosomes with endosomes or lysosomes to induce phagosome maturation, characterized by reactive oxygen species production and acidification.	Oxygen	251-257	synaptosome associated protein 23	Homo sapiens	0-6
32164457-4	2020	In the face of perceived nutrient and oxygen deprivation, cells activate low-energy sensors, which include sirtuin-1 (SIRT1), adenosine monophosphate-activated protein kinase (AMPK) and hypoxia inducible factors (especially HIF-2alpha); these enzymes and transcription factors are master regulators of hundreds of genes and proteins that maintain cellular homeostasis.	Oxygen	38-44	sirtuin 1	Homo sapiens	107-116
31999362-0	2020	Spatial Distributions of Oxygen Stable Isotope Ratios in Tap Water From Mexico for Region of Origin Predictions of Unidentified Border Crossers.	Oxygen	25-31	nuclear RNA export factor 1	Homo sapiens	57-60
18208457-12	2008	Singlet oxygen sensitized by the MOX triplet state was also detected only in oxygen-saturated D(2)O solutions, with a quantum yield of 0.075.	Oxygen	8-14	monooxygenase DBH like 1	Homo sapiens	33-36
31999362-5	2020	Here, the spatial deficiency in isotopic reference data for Mexico, specifically for oxygen (delta18 O) isotopes in tap water, is being addressed through the collection and analysis of over 150 water samples and explored with tooth enamel isotopic values from recently identified Mexican nationals.	Oxygen	85-91	nuclear RNA export factor 1	Homo sapiens	116-119
32605115-6	2020	The results proposed that the hydrophilic structure of SF/PCL/CS not only revealed a highly interconnected porous construction but also that it could help cells promote the exchange of nutrients and oxygen.	Oxygen	199-205	polycystic kidney disease 2-like 1	Mus musculus	55-64
32467233-3	2020	While this defect alone does not disrupt lip formation, Msx1-deficient embryos develop a cleft lip when the mother is transiently exposed to reduced oxygen levels or to Phenytoin, a drug known to cause embryonic hypoxia.	Oxygen	149-155	msh homeobox 1	Mus musculus	56-60
32458917-2	2020	A recent report of O2-dependent aliphatic C-C bond cleavage at ambient temperature in Ni(ii) diketonate complexes supported by a tridentate nitrogen donor ligand [(MBBP)Ni(PhC(O)CHC(O)Ph)]Cl (7-Cl; MBBP = 2,6-bis(1-methylbenzimidazol-2-yl)pyridine) in the presence of NEt3 spurred our interest in further examining the chemistry of such complexes.	Oxygen	19-21	splicing factor 1	Homo sapiens	164-168
32458917-2	2020	A recent report of O2-dependent aliphatic C-C bond cleavage at ambient temperature in Ni(ii) diketonate complexes supported by a tridentate nitrogen donor ligand [(MBBP)Ni(PhC(O)CHC(O)Ph)]Cl (7-Cl; MBBP = 2,6-bis(1-methylbenzimidazol-2-yl)pyridine) in the presence of NEt3 spurred our interest in further examining the chemistry of such complexes.	Oxygen	19-21	splicing factor 1	Homo sapiens	198-202
32407092-0	2020	Nonadiabatic Electronic Energy Transfer in Chemical Oxygen-Iodine Laser: Powered by Derivative Coupling or Spin-Orbit Coupling?	Oxygen	52-58	spindlin 1	Homo sapiens	107-111
32595932-7	2020	In pulmonary arterial hypertension, specifically, plasma ADM at diagnosis correlated mainly to mean right atrial pressure (r = 0.73, p < 0.001), N-terminal prohormone of brain natriuretic peptide (r = 0.75, p < 0.001), six-minute walking distance (r = -0.57, p < 0.001), and venous oxygen saturation (r = -0.57, p < 0.001).	Oxygen	282-288	adrenomedullin	Homo sapiens	57-60
32654001-1	2020	Exposure of male Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) for 4 h resulted in significant, transient, and reversible decrease in hemolytic resistance of peripheral blood erythrocytes.	Oxygen	32-38	ATM serine/threonine kinase	Rattus norvegicus	39-42
18451309-8	2008	These data suggest that the hematopoietic microenvironment required for erythropoiesis is dynamically regulated by oxygen through the functions of HIF-2alpha in ECs.	Oxygen	115-121	endothelial PAS domain protein 1	Mus musculus	147-157
32238418-1	2020	Oxygen surrogates (OSs) have been used to support cytochrome P450 enzymes for diverse purposes in drug metabolism research, including reaction phenotyping, mechanistic and inhibition studies, studies of redox partner interactions, and to avoid the need for NADPH or a redox partner.	Oxygen	0-6	2,4-dienoyl-CoA reductase 1	Homo sapiens	257-262
32528056-5	2020	Moreover, increased levels of reactive oxygen species in the Sestrin2-deficient corneal epithelium promote the nuclear localization and dephosphorylation of YAP, activating it to enhance the proliferation of corneal epithelial cells.	Oxygen	39-45	sestrin 2	Mus musculus	61-69
32048876-7	2020	Furthermore, scavengers of O2- or mitoROS prevented enhanced PKCbeta-dependent vasoconstrictor reactivity to endothelin-1 in pulmonary arteries from IH rats.	Oxygen	27-29	protein kinase C, alpha	Rattus norvegicus	61-68
32338336-6	2020	Following oxygen and glucose deprivation (OGD) in SH-SY5Y cells, the mitochondrial AIF was translocated into nucleus after 12 h. The co-immunoprecipitation analysis showed that the interaction between AIF and MIF was activated by OGD and subsequently resulted in MIF nuclear translocation.	Oxygen	10-16	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	83-86
18323789-2	2008	The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha, the principal regulator of cellular adaptation to low oxygen, is strongly expressed in skin epithelium.	Oxygen	124-130	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-56
32338336-6	2020	Following oxygen and glucose deprivation (OGD) in SH-SY5Y cells, the mitochondrial AIF was translocated into nucleus after 12 h. The co-immunoprecipitation analysis showed that the interaction between AIF and MIF was activated by OGD and subsequently resulted in MIF nuclear translocation.	Oxygen	10-16	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	201-204
32266604-5	2020	We show that wild-type Neuro2a cells exposed to GM1 oligosaccharide displayed an increased mitochondrial density and an enhanced mitochondrial activity together with reduced reactive oxygen species levels.	Oxygen	183-189	coenzyme Q10A	Mus musculus	48-51
18323789-2	2008	The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha, the principal regulator of cellular adaptation to low oxygen, is strongly expressed in skin epithelium.	Oxygen	124-130	hypoxia inducible factor 1, alpha subunit	Mus musculus	58-68
32633386-13	2020	There was a remarkable association between CT genotype at IL-18 gene locus rs360715 and partial pressure of oxygen (PaO2) (p=0.035), and between CC genotype at IL-9 gene locus rs2066758 and partial pressure of carbon dioxide (PaCO2) (p=0.041).	Oxygen	108-114	interleukin 18	Homo sapiens	58-63
18551109-2	2008	We screened a population of 150 whites (103F/47M) resident in NE Scotland, United Kingdom, for variants of the FTO gene and linked these to phenotypic variation in their energy expenditure (basal metabolic rate (BMR) and maximal oxygen consumption VO(2)max) and energy intake.	Oxygen	229-235	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	111-114
31654225-0	2020	Dexmedetomidine Protects Against Oxygen-Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway.	Oxygen	33-39	TSC complex subunit 2	Homo sapiens	117-121
31883956-8	2020	GDF 15 significantly positively correlated with the modified Ross score, mean pulmonary artery pressure, oxygen extraction rate (OER), and Ln NT-pro-BNP, but negatively correlated with age, oxygen delivery and its components, and estimated glomerular filtration rate (eGFR).	Oxygen	105-111	growth differentiation factor 15	Homo sapiens	0-6
31883956-8	2020	GDF 15 significantly positively correlated with the modified Ross score, mean pulmonary artery pressure, oxygen extraction rate (OER), and Ln NT-pro-BNP, but negatively correlated with age, oxygen delivery and its components, and estimated glomerular filtration rate (eGFR).	Oxygen	190-196	growth differentiation factor 15	Homo sapiens	0-6
31883956-10	2020	CONCLUSIONS: GDF 15 mainly reflects oxygen demand-supply relationship and can be used as a diagnostic marker of HF in unrepaired CHD with left to right shunt for a wide range of age and diagnoses.	Oxygen	36-42	growth differentiation factor 15	Homo sapiens	13-19
18444677-3	2008	Lewis acid activation of BH3 x NMe3 increases the reaction rate and renders the borane the most electrophilic species, which associates to the more electron-rich oxygen of the acetal.	Oxygen	162-168	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	31-35
32165297-6	2020	Initially, we identified that NDRG1 expression varies with oxygen content.	Oxygen	59-65	N-myc downstream regulated 1	Homo sapiens	30-35
31094281-9	2020	Reduced klotho concentrations were associated with markers of overnight hypoxemia determined with O2 desaturation index (r = -0.31, p = 0.01), percentage of sleep time spent with saturation &lt;90% (r = -0.41, p &lt; 0.01), and minimal saturation during sleep (r = 0.33, p = 0.01).	Oxygen	98-100	klotho	Homo sapiens	8-14
32043801-5	2020	This work could not only provide a deep insight to understand the reduction mechanisms of O 2 on Au in electrolytes at different pH values, but also supply a new idea for the selection and optimization of the electrolytes and efficient electrocatalysts for oxygen reduction.	Oxygen	257-263	immunoglobulin kappa variable 1D-39	Homo sapiens	90-93
32315147-2	2020	Among the number of key reasons generating the instability of perovskite oxide, surface-accumulated positively charged defects (oxygen vacancy, Vo  ) have been considered as the most crucial driver in strongly attracting negatively charged defects (SrA-site") toward the surface.	Oxygen	128-134	steroid receptor RNA activator 1	Homo sapiens	249-252
32103631-2	2020	In this work, first time we report d eep eutectic solvents (DESs) assisted synthesis of flower structured BiOCl/BiVO 4 (BOC/BVO) with g-C 3 N 4 (BOC/BVO/g-CN) ternary heterojunction composites were successfully prepared using a simple wet-chemical method as a good acidic and alkaline oxygen evolution reaction (OER) catalysts.	Oxygen	285-291	BOC cell adhesion associated, oncogene regulated	Homo sapiens	106-157
32442996-9	2020	It is thought that the oxygen vacancies bring about unequal number of Fe2+and Fe3+ions and thereby strengthen the magnetic frustration among the iron ions coupled with antiferromagnetic interactions, leading to the spin glass behavior.	Oxygen	23-29	spindlin 1	Homo sapiens	215-219
32250633-4	2020	Upon blue light irradiation (430 nm), CNPPtCP/si(c-fos) could generate oxygen-independent N3  with mild oxidation energy for efficient endo/lysosomal escape through N3 -assisted photochemical internalization with less gene deactivation.	Oxygen	71-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
18487208-2	2008	Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron.	Oxygen	45-47	heme oxygenase 1	Homo sapiens	6-22
32398316-9	2020	Syk-deficient neutrophils are unable to control the human pathogens Candida albicans, Candida glabrata, and Candida auris Neutrophil responses to Candida species, including the production of reactive oxygen species and of cytokines such as tumor necrosis factor alpha (TNF-alpha), the formation of neutrophil extracellular traps (NETs), phagocytosis, and neutrophil swarming, appear to be critically dependent on Syk.	Oxygen	200-206	spleen associated tyrosine kinase	Homo sapiens	0-3
32440463-3	2020	The nonflammable level of PNK-CMP fabricated via the condensation of 2,2"-(1,4-phenylene)diacetonitrile (DAN) and hexakis(4-acetylphenoxy)cyclotriphosphazene (HACTP) through Knoevenagel reaction, in vertical burning tests reached V-2 class (UL-94) and the limiting oxygen index (LOI) reached 20.8 %.	Oxygen	265-271	polynucleotide kinase 3'-phosphatase	Homo sapiens	26-29
32511514-11	2020	Results Following nebulized in-line administration of dornase alfa with albuterol, the fraction of inspired oxygen requirements was reduced for all five patients.	Oxygen	108-114	deoxyribonuclease 1	Homo sapiens	54-66
18487208-2	2008	Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron.	Oxygen	45-47	heme oxygenase 1	Homo sapiens	24-29
33463260-4	2020	This multifunctional nanovesicle was constructed by fluorinated cationic polymer C9F17-PAsp(DET) with PEG-conjugated protoporphyrin IX (PEG-PpIX) modification, which could yield the simultaneous loading of perfluorohexane (PFH) and oxygen.	Oxygen	232-238	carboxypeptidase B1	Homo sapiens	87-91
18558110-5	2008	With a 2 min deposition time in the presence of oxygen, linear calibration curves were obtained in a wide concentration range (about 2-0.001 microM) with detection limits of 8.6 nM (0.56 microg dm(-3)) for Zn2+, 1.1 nM (0.12 microg dm(-3)) for Cd2+ and 0.37 nM (0.077 microg dm(-3)) for Pb(2+).	Oxygen	48-54	CD2 molecule	Homo sapiens	244-247
32397486-4	2020	An appreciable decrease in Tyr activity was observed upon exposure to oxygen-containing DBD.	Oxygen	70-76	tyrosinase	Homo sapiens	27-30
32375802-2	2020	Malignant cells can undergo genetic and adaptive changes that prevent them from dying due to oxygen deprivation through expressions of hypoxia-inducible factor 1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Felis catus	169-179
32173524-8	2020	Compared with normoxia, a 10% oxygen environment promoted myogenin and the expression of mTOR, p70s6K, and the metabolic signal AMPK.	Oxygen	30-36	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	95-101
18521186-0	2008	Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.	Oxygen	71-77	leukemia inhibitory factor	Mus musculus	0-26
32393788-3	2020	The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy.	Oxygen	88-94	KRAS proto-oncogene, GTPase	Homo sapiens	116-120
32267717-3	2020	O2 level below CPN pertinent to the placenta results in placental hypoxia.	Oxygen	0-2	carboxypeptidase N subunit 1	Homo sapiens	15-18
18521186-6	2008	Lif(-/-) mice resisted hyperoxygen insult in the oxygen-induced retinopathy model, whereas they paradoxically had increased numbers of neovascular tufts.	Oxygen	28-34	leukemia inhibitory factor	Mus musculus	0-3
18331421-3	2008	The alveolar-to-arterial oxygen partial pressure difference (AaDO2) was large at rest in upright subjects at sea level (23, range 5-38 mmHg) while the arterial pressure of oxygen (PaO2) was low (81, range 50-95 mmHg).	Oxygen	25-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
32366527-3	2020	Their work suggests a role for stromally expressed NADPH oxidase 4 (NOX4) as a modulator of reactive oxygen species that in turn can reduce the number of CD8+ T cells locally.	Oxygen	101-107	CD8a molecule	Homo sapiens	154-157
32255634-8	2020	Those identified from the unimolecular decay of syn-MACR-oxide and subsequent reaction of O2 are acetaldehyde (37 +- 7%), vinyl alcohol (9 +- 1%), methylketene (2 +- 1%), and acrolein (52 +- 5%).	Oxygen	90-92	synemin	Homo sapiens	48-51
32324472-8	2020	Although molecular mechanisms of hypoxia tolerance are not universally apparent across marine mammal genomic studies, altered evolutionary rates have been identified for genes linked to oxygen binding and transport (e.g., MB, HBA, HBB), blood pressure control (e.g., endothelin pathway genes), and cell protection in multiple species.	Oxygen	186-192	keratin 90, pseudogene	Homo sapiens	226-229
31567534-0	2020	Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure.	Oxygen	9-15	thioredoxin H-type 2	Nicotiana tabacum	64-75
19696944-5	2008	Hydronium ions contribute to the formation of the reactive tert-butyl carbocation, which undergoes secondary reactions in the presence of reactive forms of chlorine and oxygen.	Oxygen	169-175	telomerase reverse transcriptase	Homo sapiens	59-63
32492011-1	2020	The iron-containing protein neuroglobin (Ngb) involved in the transport of oxygen is generally considered the precursor of all animal globins.	Oxygen	75-81	neuroglobin	Homo sapiens	28-39
18310660-4	2008	We characterized the diversity of hepcidin genes of the Antarctic notothenioid fishes that are endemic to the world"s coldest and most oxygen-rich marine water.	Oxygen	135-141	hepcidin antimicrobial peptide	Homo sapiens	34-42
32492011-1	2020	The iron-containing protein neuroglobin (Ngb) involved in the transport of oxygen is generally considered the precursor of all animal globins.	Oxygen	75-81	neuroglobin	Homo sapiens	41-44
32073751-4	2020	Silencing of GARP in human ASCs increased their activation of TGF-beta which augmented the levels of mitochondrial reactive oxygen species (mtROS), resulting in DNA damage, a block in proliferation and apoptosis.	Oxygen	124-130	leucine rich repeat containing 32	Homo sapiens	13-17
32411799-6	2020	The fundamental role of hScrib and hDlg1 during the establishment of the immunological synapse, hence T cell activation, and the recently described role of hScrib in reactive oxygen species production in macrophages and of hDlg1 in cytokine production by dendritic cells highlight the importance of both proteins in immune cell biology.	Oxygen	175-181	scribble planar cell polarity protein	Homo sapiens	156-162
32144202-7	2020	Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes.	Oxygen	99-105	phosphoglycerate mutase family member 5	Mus musculus	139-144
18497821-5	2008	We propose that these anomalies track those of atmospheric oxygen and in turn reflect the partial pressure of carbon dioxide (P(CO2)) in the past through a photochemical reaction network linking stratospheric ozone to carbon dioxide and to oxygen.	Oxygen	59-65	complement C2	Homo sapiens	126-131
32144202-8	2020	We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria.	Oxygen	57-63	phosphoglycerate mutase family member 5	Mus musculus	14-19
32227049-4	2020	It was found that an oxygen molecule spontaneously dissociates on the AlP, GaP and InP monolayers.	Oxygen	21-27	ATHS	Homo sapiens	70-73
18497821-5	2008	We propose that these anomalies track those of atmospheric oxygen and in turn reflect the partial pressure of carbon dioxide (P(CO2)) in the past through a photochemical reaction network linking stratospheric ozone to carbon dioxide and to oxygen.	Oxygen	240-246	complement C2	Homo sapiens	126-131
18493604-4	2008	We examined Cytochrome C oxidase subunit I (COI) in detail, and show that it experienced extensive modification of normally conserved residues involved in proton transport and delivery of electrons and oxygen.	Oxygen	202-208	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	23-42
32111738-1	2020	Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen-oxygen bond of dioxygen, followed by the incorporation of one oxygen atom into the substrate molecule with the aid of NADPH and FAD.	Oxygen	29-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	194-199
32111738-1	2020	Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen-oxygen bond of dioxygen, followed by the incorporation of one oxygen atom into the substrate molecule with the aid of NADPH and FAD.	Oxygen	69-75	2,4-dienoyl-CoA reductase 1	Homo sapiens	194-199
32111738-1	2020	Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen-oxygen bond of dioxygen, followed by the incorporation of one oxygen atom into the substrate molecule with the aid of NADPH and FAD.	Oxygen	91-99	2,4-dienoyl-CoA reductase 1	Homo sapiens	194-199
32111738-1	2020	Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen-oxygen bond of dioxygen, followed by the incorporation of one oxygen atom into the substrate molecule with the aid of NADPH and FAD.	Oxygen	69-75	2,4-dienoyl-CoA reductase 1	Homo sapiens	194-199
18493604-4	2008	We examined Cytochrome C oxidase subunit I (COI) in detail, and show that it experienced extensive modification of normally conserved residues involved in proton transport and delivery of electrons and oxygen.	Oxygen	202-208	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	44-47
18252813-1	2008	Many cardiovascular diseases are associated with reduced levels of bioactive nitric oxide (NO) and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase (eNOS uncoupling).	Oxygen	116-122	nitric oxide synthase 3, endothelial cell	Mus musculus	179-183
31935437-5	2020	RESULTS: Oxygen consumption without ATP synthase activation (leak) was significantly higher in the glycolytic muscles of Wfs1 KO mice compared to wild types.	Oxygen	9-15	wolframin ER transmembrane glycoprotein	Mus musculus	121-125
18332118-1	2008	Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis.	Oxygen	41-47	egl-9 family hypoxia-inducible factor 3	Mus musculus	108-112
31697031-2	2020	This study aimed to access variant ALDH3A2 gene coded for FALDH and products regulating pathogenic melanogenesis owing to increased oxidative stress and reactive oxygen species resulting in DNA harm in SLS.	Oxygen	162-168	aldehyde dehydrogenase 3 family member A2	Homo sapiens	35-42
31697031-2	2020	This study aimed to access variant ALDH3A2 gene coded for FALDH and products regulating pathogenic melanogenesis owing to increased oxidative stress and reactive oxygen species resulting in DNA harm in SLS.	Oxygen	162-168	aldehyde dehydrogenase 3 family member A2	Homo sapiens	58-63
18711622-0	2008	Familial erythrocytosis arising from a gain-of-function mutation in the HIF2A gene of the oxygen sensing pathway.	Oxygen	90-96	endothelial PAS domain protein 1	Homo sapiens	72-77
31641986-5	2020	Our findings suggest that a long-term high-salt diet increases TLR4 expression in the PVN and this promotes the activation of c-Src, which upregulates the expression of pro-inflammatory cytokines and results in the overproduction of reactive oxygen species.	Oxygen	242-248	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	126-131
18711622-3	2008	In addition to VHL and PHD2 a further member of the oxygen sensing pathway, namely HIF-2 alpha,can be a cause of erythrocytosis.	Oxygen	52-58	endothelial PAS domain protein 1	Homo sapiens	83-94
31995668-9	2020	Urine GRP levels correlated with duration of NICU ventilatory and oxygen support and with biomarkers of oxidative stress: allantoin and 8-hydroxydeoxyguanosine.	Oxygen	66-72	gastrin releasing peptide	Homo sapiens	6-9
18047470-2	2008	The expression and transcriptional activity of the HIF-1alpha subunit is stringently controlled by intracellular oxygen tension through the action of prolyl and asparaginyl hydroxylases.	Oxygen	113-119	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
31764761-1	2020	BACKGROUND: The optimal perfusate partial oxygen pressure (pO2) during hypothermic machine perfusion (HMP) is unknown.	Oxygen	42-48	PO2	Sus scrofa	59-62
18336467-3	2008	In the present study, we hypothesized that 20% O2 in culture represents a sufficient stimulus to cause increased expression of two key negative regulators of the cell-cycle Cip/Kip family of cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), in MPCs.	Oxygen	47-49	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	241-244
18336467-3	2008	In the present study, we hypothesized that 20% O2 in culture represents a sufficient stimulus to cause increased expression of two key negative regulators of the cell-cycle Cip/Kip family of cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), in MPCs.	Oxygen	47-49	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	245-249
32322666-4	2020	The tumorigenic metabolism transformation was confirmed through the increase of the extracellular acidification rate (ECAR) and decrease of the oxygen consumption rate (OCR) in CDC20-knockdown cells.	Oxygen	144-150	cell division cycle 20	Mus musculus	177-182
18336467-8	2008	Furthermore, 20% O2 caused an increase in p21(Cip1) mRNA stability and p53 transcription factor activity.	Oxygen	17-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	71-74
32269715-7	2020	During the indicated procedure, SOR-resistant HCC cells-Huh7-SOR presented EMT-like morphologic change and underwent glycolysis to OXPHOS switch, representing reduced glucose consumption and lactate production, but increased oxygen consumption level and intercellular ATP levels.	Oxygen	225-231	MIR7-3 host gene	Homo sapiens	56-60
32215176-16	2020	Our findings demonstrate that TRPM7 knockdown promotes HIF-1alpha degradation via an oxygen-independent mechanism involving increased binding of RAKC1 to HIF-1alpha, and TRPM7-HIF-1alpha-Annexin A1 signaling axis plays a crucial role in the EMT, cell migration, and invasion of androgen-independent prostate cancer cells under hypoxic conditions.	Oxygen	85-91	transient receptor potential cation channel subfamily M member 7	Homo sapiens	30-35
32215176-16	2020	Our findings demonstrate that TRPM7 knockdown promotes HIF-1alpha degradation via an oxygen-independent mechanism involving increased binding of RAKC1 to HIF-1alpha, and TRPM7-HIF-1alpha-Annexin A1 signaling axis plays a crucial role in the EMT, cell migration, and invasion of androgen-independent prostate cancer cells under hypoxic conditions.	Oxygen	85-91	annexin A1	Homo sapiens	187-197
18174394-0	2008	Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats.	Oxygen	54-60	erythropoietin	Rattus norvegicus	138-152
32003079-4	2020	Catalysts with magnetically polarized channels could selectively remove electrons with opposite magnetic moment and conserve overall spin during OER, enhancing triplet state oxygen molecule evolution.	Oxygen	174-180	spindlin 1	Homo sapiens	133-137
32003079-9	2020	Such channels are able to enhance the selective removal of spin-oriented electrons from the reactants during the OER, which facilitates the accumulation of appropriate magnetic moments for triplet oxygen molecule evolution.	Oxygen	197-203	spindlin 1	Homo sapiens	59-63
18354193-8	2008	Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen.	Oxygen	185-191	hypoxia inducible factor 1, alpha subunit	Mus musculus	36-46
31991048-4	2020	In cultured human myotubes, TRF2 downregulation did not trigger telomere dysfunction, but suppressed expression of the mitochondrial Sirtuin 3 gene (SIRT3) leading to mitochondrial respiration dysfunction and increased levels of reactive oxygen species.	Oxygen	238-244	telomeric repeat binding factor 2	Homo sapiens	28-32
18356317-2	2008	Soybean ferritin (SBFn), a large, stable protein nanocage around a mineral with hundreds of iron and oxygen atoms, is a source of nutritional iron with an unknown mechanism for intestinal absorption.	Oxygen	101-107	ferritin-1, chloroplastic	Glycine max	8-16
31532909-2	2020	Here we demonstrate that the demand of LPMO for an electron donor and an oxygen species as cosubstrate can be fulfilled by a single auxiliary enzyme: an engineered fungal cellobiose dehydrogenase (CDH) with increased oxidase activity.	Oxygen	73-79	choline dehydrogenase	Homo sapiens	171-195
31532909-2	2020	Here we demonstrate that the demand of LPMO for an electron donor and an oxygen species as cosubstrate can be fulfilled by a single auxiliary enzyme: an engineered fungal cellobiose dehydrogenase (CDH) with increased oxidase activity.	Oxygen	73-79	choline dehydrogenase	Homo sapiens	197-200
18082251-1	2008	The purpose of this research was to investigate the potential causes of low oxygen levels in the bottom water of the Oyster Grounds region of the shallow southern North Sea, an area which provides suitable conditions for low oxygen levels to develop.	Oxygen	76-82	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	169-172
31517390-10	2020	In the OGD model, overexpression of miR-31 and silencing of PKD1 attenuated oxidative stress-induced neuronal injury, and diminished the lactate dehydrogenase leakage and reactive oxygen species level, accompanied by elevated neuronal viability.	Oxygen	180-186	protein kinase D1	Mus musculus	60-64
18082251-1	2008	The purpose of this research was to investigate the potential causes of low oxygen levels in the bottom water of the Oyster Grounds region of the shallow southern North Sea, an area which provides suitable conditions for low oxygen levels to develop.	Oxygen	225-231	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	169-172
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	30-36	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	227-248
31709646-1	2020	BACKGROUND: Reactive oxygen species modulator 1 (ROMO1) is recognized to be involved in cell proliferation and is elevated in serum of various cancer patients.	Oxygen	21-27	reactive oxygen species modulator 1	Homo sapiens	49-54
32040259-2	2020	The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production.	Oxygen	135-141	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	4-23
32040259-2	2020	The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production.	Oxygen	135-141	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	25-28
32400767-4	2020	Reactive oxygen/nitrogen species, cytokines and matrix metalloproteinases (MMPs) are implicated in the pathogenesis of diabetic neuropathy.	Oxygen	9-15	matrix metallopeptidase 9	Rattus norvegicus	75-79
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	30-36	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	250-253
32277013-6	2020	The HPF1 repeat expansion shifted yeast cells from a sedentary to a buoyant state, thereby increasing their exposure to surrounding oxygen.	Oxygen	132-138	mannoprotein	Saccharomyces cerevisiae S288C	4-8
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	38-43	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	227-248
31813325-0	2020	Hyperbaric oxygen suppresses stemness-associated properties and Nanog and oncostatin M expression, but upregulates beta-catenin in orthotopic glioma models.	Oxygen	11-17	Nanog homeobox	Homo sapiens	64-69
32043704-12	2020	The diverting research unveiled that KISS1 repression eased H2 O2 -caused HTR8 cells injury via mediating PI3K/AKT/mTOR pathway.	Oxygen	63-65	KiSS-1 metastasis suppressor	Homo sapiens	37-42
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	38-43	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	250-253
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	38-42	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	227-248
31907582-4	2020	It was found that ERK1/2 phosphorylation induced by CsA was highly reduced in the presence of the reactive oxygen species (ROS) scavenger polyethylene glycol-superoxide dismutase (PEG-SOD).	Oxygen	107-113	chorionic somatomammotropin hormone 1	Homo sapiens	52-55
32152212-7	2020	tomato DC3000 and the necrotrophic fungus Botrytis cinerea As pldgamma1 mutant plants responded with elevated levels of reactive oxygen species to MAMP treatment, a negative regulatory function for this PLD isoform is proposed.	Oxygen	129-135	phospholipase D gamma 1	Arabidopsis thaliana	62-71
32152212-7	2020	tomato DC3000 and the necrotrophic fungus Botrytis cinerea As pldgamma1 mutant plants responded with elevated levels of reactive oxygen species to MAMP treatment, a negative regulatory function for this PLD isoform is proposed.	Oxygen	129-135	phospholipase D alpha 1	Arabidopsis thaliana	203-206
31571659-0	2020	Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway.	Oxygen	37-43	mechanistic target of rapamycin kinase	Rattus norvegicus	114-118
31926268-6	2020	Besides, Mfn2 overexpression promoted an ROS (reactive oxygen species)-dependent mitophagy via PINK1 (PTEN-induced putative kinase protein 1)/Parkin pathway in TBHP-treated NPCs.	Oxygen	55-61	mitofusin 2	Rattus norvegicus	9-13
18347341-1	2008	Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)].	Oxygen	38-42	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	250-253
31961241-11	2020	Conclusion Gradient-echo spin-echo echo-planar imaging sequence provided quantitative T2 and T2* maps per heartbeat and enabled dynamic heartbeat-to-heartbeat blood oxygen level-dependent (BOLD)-response imaging by analyzing changes in T2 and T2* over the time of a breath-hold intervention.	Oxygen	165-171	spindlin 1	Homo sapiens	25-29
32312382-3	2020	By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by laser-wounding.	Oxygen	242-248	vascular endothelial growth factor A	Mus musculus	60-65
18239183-0	2008	Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia.	Oxygen	11-17	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-77
32257839-2	2020	The derivative known as methemoglobin results from oxidation of hemoglobin and is pathologically relevant because it cannot transport oxygen.	Oxygen	134-140	hemoglobin subunit gamma 2	Homo sapiens	24-37
17961072-7	2008	We found that ROS-induced heparin and heparan sulfate fragments induced neutrophil chemotaxis across a modified Boyden chamber, which was inhibited by the presence of EC-SOD by scavenging oxygen radicals.	Oxygen	188-194	superoxide dismutase 3, extracellular	Mus musculus	167-173
32259049-2	2020	We tested whether HGF expression and activity in mice with oxygen-induced ischemic retinopathy supports a role in macular edema.	Oxygen	59-65	hepatocyte growth factor	Mus musculus	18-21
32067737-6	2020	The pro-osteogenic role of IL-17 was dependent on Act1 and the generation of reactive oxygen species.	Oxygen	86-92	interleukin 17A	Mus musculus	27-32
18059190-5	2008	Myeloperoxidase activity in the proximal and mid small intestine were significantly lower in 5-FU+OO-treated rats compared to 5-FU+vehicle-treated controls (p &lt; 0.05).	Oxygen	98-100	myeloperoxidase	Rattus norvegicus	0-15
32090830-3	2020	The experimental results showed the blue AG-PBR to be more effective in removing chemical oxygen demand (COD), total nitrogen (TN) and ammonia nitrogen (NH3-N) and generating biomass productivity than those of the red AG-PBR (P &lt; 0.05).	Oxygen	90-96	translocator protein	Homo sapiens	44-47
31799800-7	2020	The results support that the unexpected carbon corrosion occurring at such low potential in the presence of O 2 is due to reactive oxygen species produced between H 2 O 2 and Fe sites via Fenton reactions.	Oxygen	131-137	immunoglobulin kappa variable 1D-39	Homo sapiens	108-111
31799800-7	2020	The results support that the unexpected carbon corrosion occurring at such low potential in the presence of O 2 is due to reactive oxygen species produced between H 2 O 2 and Fe sites via Fenton reactions.	Oxygen	131-137	immunoglobulin kappa variable 1D-39	Homo sapiens	167-170
31860894-3	2020	Based on our thorough characterization, analysis and modeling, we show that the physical origin of this electrical behavior relies on controlled oxygen vacancies electromigration between three different nanoscopic zones of the active Ta2O5-x layer: a central one and two quasi-symmetric interfaces with reduced TaO2-h(y) layers.	Oxygen	145-151	TAO kinase 2	Homo sapiens	311-315
18219388-2	2008	In this issue of the JCI, Chen, Smith, and colleagues demonstrate that the temporal expression of Epo is critical for determining whether physiological or pathological repair occurs following neurovascular retinal injury in the oxygen-induced retinopathy neonatal mouse model (see the related article beginning on page 526).	Oxygen	228-234	erythropoietin	Mus musculus	98-101
32175544-3	2020	GOx reduces atmospheric O2 to H2O2, causing a cyclic change of cerium ion states, resulting in propagating free radicals in the carbon group in the amino functionalised nanoceria surface.	Oxygen	24-26	hydroxyacid oxidase 1	Homo sapiens	0-3
32175544-6	2020	GOx held two major roles within the reaction: to provide an oxygen free system, without any other form of degassing, and to provide cyclical cerium ion states between Ce4+ and Ce3+, creating new free radicals for polymerisation.	Oxygen	60-66	hydroxyacid oxidase 1	Homo sapiens	0-3
32106292-2	2020	Here we explore the effects of inhibiting mTOR as a potential gene therapeutic against pathological retinal angiogenesis in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	139-145	mechanistic target of rapamycin kinase	Rattus norvegicus	42-46
32117965-4	2020	In the present study, we found that the protein content of Lamp2 gradually decreased in response to oxygen, glucose and serum deprivation (OGD) treatment in vitro.	Oxygen	100-106	lysosomal associated membrane protein 2	Homo sapiens	59-64
18314446-6	2008	Overexpression of NQO2 in the catecholaminergic neuroblastoma SH-SY5Y cells resulted in increased production of reactive oxygen species when exposed to exogenous dopamine.	Oxygen	121-127	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	18-22
31927911-1	2020	The work describes the interactions of nanosilver (NAg) with bacterial cell envelope components at molecular level and how this associates with the reactive oxygen species (ROS)-mediated toxicity of the nanoparticle.	Oxygen	157-163	NBAS subunit of NRZ tethering complex	Homo sapiens	51-54
32044184-2	2020	We are interested in HSP70 induction capability of an antitumor antibiotic bleomycin which produces oxidative stress by iron chelate formation and oxygen activation in a cell.	Oxygen	147-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	21-26
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	Oxygen	136-142	cytochrome b-245 beta chain	Homo sapiens	65-69
18218341-2	2008	Abeta and amyloid-precursor protein are known to localize to mitochondrial membranes, block the transport of nuclear-encoded mitochondrial proteins to mitochondria, interact with mitochondrial proteins, disrupt the electron-transport chain, increase reactive oxygen species production, cause mitochondrial damage and prevent neurons from functioning normally.	Oxygen	259-265	amyloid beta (A4) precursor protein	Mus musculus	0-5
31917192-4	2020	Consistently, previous studies have shown that up-regulation of NADPH oxidase-mediated production of reactive oxygen species (ROS) in KRIT1 deficient endothelium contributes to the loss of microvessel barrier function.	Oxygen	110-116	KRIT1 ankyrin repeat containing	Homo sapiens	134-139
31868938-6	2020	In addition, GCN2 knockdown significantly suppressed the production of reactive oxygen species (ROS) and malondialdehyde (MDA), as well as increased superoxide dismutase (SOD) activity in high glucose-stimulated ARPE-19 cells.	Oxygen	80-86	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	13-17
31915155-6	2020	Using a mouse model of oxygen-induced retinopathy, p110delta inactivation was found to attenuate pathological retinal angiogenesis.	Oxygen	23-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Mus musculus	51-60
32028672-5	2020	Both miR-21-5p and miR-23-3p gene expressions were negatively correlated with apnea hypopnea index and oxygen desaturation index, while TNF-alpha gene expression positively correlated with apnea hypopnea index.	Oxygen	103-109	microRNA 215	Homo sapiens	5-14
31704719-1	2020	OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE).	Oxygen	172-178	neutrophil cytosolic factor 1	Homo sapiens	52-56
31704719-1	2020	OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE).	Oxygen	172-178	neutrophil cytosolic factor 1	Homo sapiens	63-67
31704719-1	2020	OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE).	Oxygen	172-178	neutrophil cytosolic factor 1	Homo sapiens	63-67
31704719-1	2020	OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE).	Oxygen	172-178	neutrophil cytosolic factor 1	Homo sapiens	131-138
32049639-12	2020	This study suggested that Hv1 acts as a positive regulator of metabolic homeostasis and a potential target for antiobesity drugs in therapy and may serve as an adaptive mechanism in cooperating with NOX to mediate reactive oxygen species for adipogenesis and insulin sensitivity.	Oxygen	223-229	hepatitis virus (MHV-2) susceptibility	Mus musculus	26-29
17950373-2	2008	One specific modification caused by reactive oxygen species is the oxidation of the sulfur atom in the methionine (Met) side chain.	Oxygen	45-51	SAFB like transcription modulator	Homo sapiens	115-118
31769505-2	2020	Voltage-gated proton channel (Hv1) is expressed in microglia and contributes to nicotinamide adenine dinucleotide phosphate oxidase complex (NOX)-dependent production of reactive oxygen species (ROS).	Oxygen	179-185	hepatitis virus (MHV-2) susceptibility	Mus musculus	30-33
31769505-4	2020	We previously reported that Hv1 facilitated production of ROS and pro-inflammatory cytokines in microglia and enhanced damage to oligodendrocyte progenitor cells (OPCs) from oxygen and glucose deprivation (OGD).	Oxygen	174-180	hepatitis virus (MHV-2) susceptibility	Mus musculus	28-31
32114846-6	2020	We previously demonstrated that Nox1/4 inhibition reduced retinal neovascularization in oxygen-induced retinopathy.	Oxygen	88-94	NADPH oxidase 1	Rattus norvegicus	32-36
33542935-12	2020	In the wild-type tyrosinase, the peptide oxygen atom of M374 is responsible for hydrogen bonding with H367.	Oxygen	41-47	tyrosinase	Homo sapiens	17-27
32312010-0	2020	Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1beta, platelet-derived growth factor-BB, and interleukin-1 receptor antagonist in keloids.	Oxygen	22-28	interleukin 12B	Homo sapiens	90-107
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	interleukin 12B	Homo sapiens	196-213
31760602-1	2020	The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia).	Oxygen	67-73	egl-9 family hypoxia inducible factor 3	Homo sapiens	4-24
31760602-1	2020	The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia).	Oxygen	67-73	egl-9 family hypoxia inducible factor 3	Homo sapiens	26-30
32312010-1	2020	BACKGROUND: Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1beta (MIP-1beta), platelet-derived growth factor-BB (PDGF-BB), and interleukin-1 receptor antagonist (IL-1Ra).	Oxygen	142-148	interleukin 12B	Homo sapiens	215-223
31760602-1	2020	The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia).	Oxygen	126-132	egl-9 family hypoxia inducible factor 3	Homo sapiens	4-24
18421186-8	2008	Nocturnal oximetry showed that Group A spent a greater percentage of time at pulse-oximetric oxygen saturation below 90% (CT 90) than did Group B (10.6 +/- 13.2% vs. 5.0 +/- 12.5%; p &lt; 0.01).	Oxygen	93-99	kinesin family member 20B	Homo sapiens	122-127
31760602-1	2020	The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia).	Oxygen	126-132	egl-9 family hypoxia inducible factor 3	Homo sapiens	26-30
32500117-4	2020	As autoreactive CD8+ T cells mediate disruption of insulin-producing beta-cells1-3, we demonstrate that TR3-56 cells can suppress CD8+ T cell functions in vitro by reducing levels of intracellular reactive oxygen species.	Oxygen	206-212	CD8a molecule	Homo sapiens	16-19
32315567-9	2020	Furthermore, experiments involving overexpression of recombinant ZAG reveal that its glycosylation is co-regulated by oxygen availability and that the pattern of glycosylation affects its inhibitory potential.	Oxygen	118-124	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	65-68
32206911-4	2020	Using the photoelectrode of CoxOyHz@ZIF-67/TiO2 nanotubes (NTs), glucose was oxidized firstly by dissolved oxygen to generate H2O2 under the catalysis of CoxOyHz film as the mimics of GOx.	Oxygen	107-113	hydroxyacid oxidase 1	Homo sapiens	184-187
18827416-1	2008	OBJECTIVE: Near infrared spectroscopy (NIRS) is a non-invasive optical technique to monitor cerebral tissue oxygen saturation (ScO(2)).	Oxygen	108-114	synthesis of cytochrome C oxidase 2	Homo sapiens	127-132
32851830-4	2020	Oxygen atom transfer (OAT) reactivity is discussed in terms of breaking strong metal-oxo bonds and the mechanism of OAT catalyzed by enzymes of the sulfite oxidase (SO) family that possess dioxo Mo(VI) active sites.	Oxygen	0-6	sulfite oxidase	Homo sapiens	148-163
32851830-4	2020	Oxygen atom transfer (OAT) reactivity is discussed in terms of breaking strong metal-oxo bonds and the mechanism of OAT catalyzed by enzymes of the sulfite oxidase (SO) family that possess dioxo Mo(VI) active sites.	Oxygen	0-6	sulfite oxidase	Homo sapiens	165-167
32024700-5	2020	In this study, we show that in addition to IL-1beta, PSTPIP2 also negatively regulates pathways governing reactive oxygen species generation by neutrophil NOX2 NADPH oxidase.	Oxygen	115-121	cytochrome b-245 beta chain	Homo sapiens	155-159
32019183-9	2020	Furthermore, we found that loss of Bmal1 was associated with the accumulation of Reactive Oxygen Species Modulator 1 (ROMO1), a protein responsible for inducing the production of intracellular reactive oxygen species (ROS).	Oxygen	202-208	reactive oxygen species modulator 1	Mus musculus	81-116
32019183-9	2020	Furthermore, we found that loss of Bmal1 was associated with the accumulation of Reactive Oxygen Species Modulator 1 (ROMO1), a protein responsible for inducing the production of intracellular reactive oxygen species (ROS).	Oxygen	202-208	reactive oxygen species modulator 1	Mus musculus	118-123
31687725-7	2020	In addition, reactive oxygen species triggered the activation of Nrf2 and the antioxidant system, including HO-1, r-GCS, and GSH-Px.	Oxygen	22-28	heme oxygenase 1	Rattus norvegicus	108-119
32013230-7	2020	At the molecular mechanism level, T-2 toxin induced mitochondria-mediated apoptosis by producing reactive oxygen species, promoting cytochrome c translocation between the mitochondria and cytoplasm, and thus promoting apoptosomes formation.	Oxygen	106-112	solute carrier family 25 member 5	Homo sapiens	34-37
32052980-1	2020	Spin engineering provides a powerful strategy for manipulating the interaction between electrons in d-orbital and oxygen-containing adsorbates, while little endeavor was performed to understand whether such strategy can make a prosperous enhancement for fuels electrooxidations.	Oxygen	114-120	spindlin 1	Homo sapiens	0-4
18006868-5	2008	Exposing Mecp2(+/-) animals to 40% oxygen increased the amount of periodic breathing from 118 +/- 25 s/30 min in air to 242 +/- 57 s/30 min (P = 0.001), and 12% oxygen tended to decrease it (67 +/- 29 s/30 min, P = 0.14).	Oxygen	35-41	methyl CpG binding protein 2	Mus musculus	9-14
32075375-4	2020	This great increased activity is attributed to the high percentages of oxygen vacancies on DUT-67(Zr).	Oxygen	71-77	deoxyuridine triphosphatase	Homo sapiens	91-94
32075375-5	2020	The ESR result shows there are more oxygen vacancies that can expose high density unsaturated Zr sites on DUT-67(Zr).	Oxygen	36-42	deoxyuridine triphosphatase	Homo sapiens	106-109
31948482-10	2020	Ang II infusion increased media to lumen ratio and caused fibrosis and reactive oxygen species production in the aorta of Cyp1b1+/+ mice.	Oxygen	80-86	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	122-128
18006868-5	2008	Exposing Mecp2(+/-) animals to 40% oxygen increased the amount of periodic breathing from 118 +/- 25 s/30 min in air to 242 +/- 57 s/30 min (P = 0.001), and 12% oxygen tended to decrease it (67 +/- 29 s/30 min, P = 0.14).	Oxygen	161-167	methyl CpG binding protein 2	Mus musculus	9-14
18006868-7	2008	The ventilation/apnea ratio (V/A) was less at all levels of oxygen in heterozygous Mecp2(+/-) females compare with wild type (P = 0.003 to P &lt; 0.001), indicating that their loop gain is larger.	Oxygen	60-66	methyl CpG binding protein 2	Mus musculus	83-88
31856562-2	2020	To achieve highly efficient SnO2-based PeSCs, it is necessary to control the oxygen vacancies in the SnO2 layer, since the electrical and optical properties vary depending on the oxidation state of Sn.	Oxygen	77-83	strawberry notch homolog 2	Homo sapiens	28-31
18006868-8	2008	V/A in Mecp2(+/-) fell from 2.42 +/- 0.18 in normoxia to 1.82 +/- 0.17 in hyperoxia (P = 0.05) indicating an increase in loop gain with increased oxygen.	Oxygen	146-152	methyl CpG binding protein 2	Mus musculus	7-12
32044724-4	2020	In vitro study indicated that reduced endogenous LINC00167 expression resulted in RPE dedifferentiation, which was typified by attenuated expression of RPE markers, reduced vascular endothelial growth factor A secretion, accumulation of mitochondrial reactive oxygen species, and interrupted phagocytic ability.	Oxygen	260-266	PRDM10 divergent transcript	Homo sapiens	49-58
22062097-5	2008	Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat.	Oxygen	83-89	myoglobin	Homo sapiens	155-164
31989131-9	2020	Oxygen (O2) and ammonia (NH3) gases were detected in the concentration ranges 1-20% O2 and 1-10 ppm NH3 in the two GPEs using both linear sweep voltammetry (LSV) and long-term chronoamperometry (LTCA).	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	84-92
31940810-8	2020	Obesity-driven BRCA1 upregulation is not able to be explained by DNA methylation (EPIC array) or by short-term treatment of chorionic villous explants at 2.5% oxygen with tumor necrosis factor alpha (TNF-alpha) (50 mg/mL), leptin (100 mg/mL), interleukin 6 (IL-6) (100 mg/mL), or high glucose (25 nM).	Oxygen	159-165	BRCA1 DNA repair associated	Homo sapiens	15-20
18046334-1	2008	The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia).	Oxygen	176-182	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-22
31924757-2	2020	We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass.	Oxygen	61-67	egl-9 family hypoxia-inducible factor 2	Mus musculus	84-90
18477923-2	2008	Inhaled hydrogen sulfide (H2S) has been shown to induce a suspended animation-like state in mice with a 90% decrease in oxygen consumption.	Oxygen	120-126	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	26-29
31672277-0	2020	Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.	Oxygen	81-87	lysosomal associated membrane protein 2	Homo sapiens	0-38
31769461-4	2020	Moreover, Azo achieved charge reversal in a hypoxia microenvironment caused by the sustained oxygen consumption by GOx, which resulted in selective and enhanced tumor accumulation based on the hypoxia-activated positive feedback cellular uptake.	Oxygen	93-99	hydroxyacid oxidase 1	Homo sapiens	115-118
31980577-0	2020	LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages.	Oxygen	92-98	LETM1 domain containing 1	Mus musculus	0-6
31980577-7	2020	Attenuation of LETMD1 expression caused mitochondrial hyperpolarization and subsequent decrease in ATP production and increase in mitochondrial/cellular reactive oxygen species (ROS) and intracellular calcium levels.	Oxygen	162-168	LETM1 domain containing 1	Mus musculus	15-21
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	165-170
32045211-2	2020	Here, we report A-site lanthanum-doped oxygen-rich quinary oxide CaLaScRuO6+delta synthesized by adopting the solid-state reaction method and characterized by various techniques such as powder X-ray diffraction, neutron diffraction, energy-dispersive X-ray spectroscopy, inductively coupled plasma-atomic emission spectrometry, Raman spectroscopy, and temperature-programmed reduction in the presence of a hydrogen atmosphere (H2-TPR).	Oxygen	39-45	translocated promoter region, nuclear basket protein	Homo sapiens	430-433
32045211-4	2020	Neutron powder diffraction and reduction of the material in a hydrogen atmosphere (H2-TPR) can confirm the oxygen overstoichiometry of the catalyst.	Oxygen	107-113	translocated promoter region, nuclear basket protein	Homo sapiens	86-89
32031575-0	2020	Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced Pathological Neovascularization in Murine Oxygen-Induced Retinopathy.	Oxygen	101-107	vascular endothelial growth factor A	Mus musculus	46-50
31964807-9	2020	On one hand, Cops5 suppresses the autophagic degradation of Mtch2 to direct cellular metabolism toward glycolysis and minimize reactive oxygen species (ROS) production, thereby reducing endogenous DNA damage.	Oxygen	136-142	COP9 signalosome subunit 5	Homo sapiens	13-18
31918224-0	2020	Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-alpha/BAFF signaling pathway.	Oxygen	9-15	rhomboid 5 homolog 2	Homo sapiens	137-143
31806266-2	2020	The bioisosteric replacement of oxygen in 4"-oxoadenosines with selenium significantly increased the PPARdelta-binding activity.	Oxygen	32-38	peroxisome proliferator activated receptor delta	Homo sapiens	101-110
18477923-13	2008	Central temperature and oxygen consumption significantly and linearly decreased over the H2S exposures (p &lt; .0001 for both), the rates of which were significantly less compared with those in the control group (p &lt; .01 for both).	Oxygen	24-30	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	89-92
31929872-9	2020	Hg2+-upregulated MIP-2 expression was suppressed by NAC regardless of the time sequence of the treatment, suggesting that the suppressive role of NAC in Hg2+-induced inflammation manifests as a possible chelator and antioxidant/reactive oxygen species scavenger.	Oxygen	237-243	X-linked Kx blood group	Homo sapiens	52-55
31929872-9	2020	Hg2+-upregulated MIP-2 expression was suppressed by NAC regardless of the time sequence of the treatment, suggesting that the suppressive role of NAC in Hg2+-induced inflammation manifests as a possible chelator and antioxidant/reactive oxygen species scavenger.	Oxygen	237-243	X-linked Kx blood group	Homo sapiens	146-149
19020660-8	2008	Mice lacking apoB100 also had higher oxygen consumption and lipid oxidation.	Oxygen	37-43	apolipoprotein B	Mus musculus	13-20
31608496-6	2020	Knockdown of ALK7 suppressed HG-induced reactive oxygen species (ROS) production, as well elevated the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in ARPE-19 cells.	Oxygen	49-55	activin A receptor type 1C	Homo sapiens	13-17
18473944-0	2008	Building quantitative relationship between changed sequence and changed oxygen affinity in human hemoglobin beta-chain.	Oxygen	72-78	hemoglobin subunit beta	Homo sapiens	97-112
31927658-4	2020	Interestingly, overexpression of FAL1 ameliorated OGD/R-induced oxidative stress by reducing the production of reactive oxygen species (ROS) and increasing the level of reduced glutathione (GSH).	Oxygen	120-126	focally amplified long non-coding RNA in epithelial cancer	Homo sapiens	33-37
31858374-8	2020	The results indicated that MAPK specific inhibitor and siRNA-TXNIP significantly alleviated the oxidative stress injury induced by oxygen-glucose deprivation.	Oxygen	131-145	thioredoxin interacting protein	Rattus norvegicus	61-66
18473944-1	2008	244 point mutations have been recorded in human hemoglobin beta-chain, of which some change the oxygen affinity of human hemoglobin beta-chain.	Oxygen	96-102	hemoglobin subunit beta	Homo sapiens	48-63
31870154-2	2020	This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.	Oxygen	9-17	tryptophan 2,3-dioxygenase	Homo sapiens	112-138
18473944-1	2008	244 point mutations have been recorded in human hemoglobin beta-chain, of which some change the oxygen affinity of human hemoglobin beta-chain.	Oxygen	96-102	hemoglobin subunit beta	Homo sapiens	121-136
31870154-2	2020	This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.	Oxygen	9-17	tryptophan 2,3-dioxygenase	Homo sapiens	140-143
18473944-2	2008	We use the amino-acid distribution probability to quantify these mutations, and use the cross-impact analysis with Bayes" law to determine the probability that changes the oxygen affinity of human hemoglobin beta-chain under mutations.	Oxygen	172-178	hemoglobin subunit beta	Homo sapiens	197-212
17887916-8	2007	Moreover, we have proposed HO-2 as a potential O(2) sensor, because HO-2-deficient mice show hypoxemia and a blunted hypoxic ventilatory response with normal hypercapnic ventilatory response.	Oxygen	47-51	heme oxygenase 2	Mus musculus	27-31
31949281-1	2020	Here we propose an experimental setup based on operando X-ray absorption spectroscopy (XAS) to understand why copper-containing oxidoreductase enzymes show exceptional performance as catalysts for the oxygen reduction reaction (ORR).	Oxygen	201-207	thioredoxin reductase 1	Homo sapiens	128-142
31679689-12	2020	Therefore, promoting PGRN expression could reduced cerebral I/R-induced brain injury by suppressing neroptosis and associated reactive oxygen species (ROS) production.	Oxygen	135-141	granulin	Mus musculus	21-25
18050215-7	2007	Microarray analysis demonstrated that mPGES-1 was among the genes that were up-regulated to the greatest degree in primary chondrocytes exposed to 1% O(2).	Oxygen	150-154	prostaglandin E synthase	Mus musculus	38-45
31790233-7	2020	We observed that the growth of photogranules significantly impacts their capability of producing oxygen, the key element in OPG wastewater treatment.	Oxygen	97-103	basic transcription factor 3 pseudogene 11	Homo sapiens	124-127
17964427-3	2007	SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric oxygen, and sodium azide.	Oxygen	106-112	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	0-5
31893387-2	2020	The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes.	Oxygen	49-55	HBD	Homo sapiens	67-70
32985231-7	2020	Finally, oxygen and glucose deprivation reduced GFAP expression and the colocalization and molecular association of GFAP with aquaporin 4 in the SON in brain slices.	Oxygen	9-15	glial fibrillary acidic protein	Rattus norvegicus	48-52
17823295-2	2007	We examined the profile of the deoxygenated hemoglobin signal from NIRS {deoxygenated hemoglobin + myoglobin [deoxy-(Hb+Mb)] approximately O(2) extraction} during ramp exercise to test the hypothesis that the increase in estimated O(2) extraction would be close to hyperbolic, reflecting a linear relationship between muscle blood flow (Q(m)) and muscle oxygen uptake (Vo(2)(m)) with a positive Q(m) intercept.	Oxygen	33-39	myoglobin	Homo sapiens	99-108
32985231-7	2020	Finally, oxygen and glucose deprivation reduced GFAP expression and the colocalization and molecular association of GFAP with aquaporin 4 in the SON in brain slices.	Oxygen	9-15	glial fibrillary acidic protein	Rattus norvegicus	116-120
31697929-1	2020	beta2-adrenergic receptor (beta2AR) agonists are clinically used to elicit rapid bronchodilation for the treatment of bronchospasms in pulmonary diseases such as asthma and COPD, both of which exhibit characteristically high levels of reactive oxygen species (ROS); likely secondary to over-expression of ROS generating enzymes and chronically heightened inflammation.	Oxygen	244-250	adrenoceptor beta 2	Homo sapiens	0-25
31697929-1	2020	beta2-adrenergic receptor (beta2AR) agonists are clinically used to elicit rapid bronchodilation for the treatment of bronchospasms in pulmonary diseases such as asthma and COPD, both of which exhibit characteristically high levels of reactive oxygen species (ROS); likely secondary to over-expression of ROS generating enzymes and chronically heightened inflammation.	Oxygen	244-250	adrenoceptor beta 2	Homo sapiens	27-34
31950842-2	2020	Due to important effect of oxygen on cells radio sensitivity, tumor blood circulation and it"s antigens like ABO blood groups maybe an important predictive factor for radiotherapy response and it is adverse events.	Oxygen	27-33	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	109-112
31683467-5	2020	Sct(O2) was monitored at pre-induction (T0), post-induction (T1), 30 min (T2) after single-lung ventilation, and after surgery (T3).	Oxygen	4-6	secretin	Homo sapiens	0-3
17694278-2	2007	These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen.	Oxygen	170-176	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	76-80
31683467-10	2020	CONCLUSION: Dexmedetomidine can alleviate the decrease of Sct(O2) during single-lung ventilation, improve postoperative cognitive function, and reduce the incidence of POCD in elderly patients with minimally invasive coronary artery bypass surgery.	Oxygen	62-64	secretin	Homo sapiens	58-61
17644143-2	2007	In this investigation, healthy subjects were exposed to hypoxia by inhalation of 10% oxygen for 2h (corresponding to 5500m above sea level).	Oxygen	85-91	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	129-132
32065102-6	2020	To exert such protective activities, TSPO increases the synthesis of neuroprotective steroids, decreases neuroinflammation, limits the opening of mPTP, and reduces the generation of reactive oxygen species.	Oxygen	191-197	translocator protein	Homo sapiens	37-41
31568632-1	2020	The transient receptor potential melastatin-related 2 (TRPM2) channel, a reactive oxygen species (ROS)-sensitive cation channel, has been well recognized for being an important and common mechanism that confers the susceptibility to ROS-induced cell death.	Oxygen	82-88	transient receptor potential cation channel subfamily M member 2	Homo sapiens	4-53
17609976-8	2007	The secretion of IL-6, leptin, MIF and VEGF from the adipocytes was also stimulated by exposure to 1% O(2).	Oxygen	102-106	leptin	Homo sapiens	23-29
31568632-1	2020	The transient receptor potential melastatin-related 2 (TRPM2) channel, a reactive oxygen species (ROS)-sensitive cation channel, has been well recognized for being an important and common mechanism that confers the susceptibility to ROS-induced cell death.	Oxygen	82-88	transient receptor potential cation channel subfamily M member 2	Homo sapiens	55-60
17996713-5	2007	Elevated levels of 4E-BP1 trigger hypoxia inhibition of cap-dependent mRNA translation at high-oxygen levels and, with eIF4G, increase selective translation of mRNAs containing internal ribosome entry sites (IRESs) that include key proangiogenic, hypoxia, and survival mRNAs.	Oxygen	95-101	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	19-25
31778952-3	2020	Here we show that an increase of oxidative stress (ROS and singlet oxygen), generated by photoactivated TMPyP4, results in the upregulation of KRAS and Nrf2, the major regulator of the redox homeostasis.	Oxygen	67-73	KRAS proto-oncogene, GTPase	Homo sapiens	143-147
31868740-5	2020	Angular-dependent X-ray absorption analyses at the O K-edge reveal enhanced surface-state contributions and asymmetric O 2p orbital occupations in the (000\bar 1)-terminated o-plane ZnO compound.	Oxygen	174-181	immunoglobulin kappa variable 1D-39	Homo sapiens	119-123
17855480-8	2007	Together, these studies combine genetic and pharmacological in vivo evidence that increases of EPO secretion during limited oxygen availability are not affected by extracellular adenosine generation or signaling.	Oxygen	124-130	erythropoietin	Mus musculus	95-98
31563085-8	2020	Up-regulation of both Nox2 and Nox1 was associated with augmented O2.- production but reduced H2O2 generation and blunted endothelial Nox2-derived H2O2-mediated in obese rats.	Oxygen	66-69	cytochrome b-245 beta chain	Rattus norvegicus	22-26
31563085-8	2020	Up-regulation of both Nox2 and Nox1 was associated with augmented O2.- production but reduced H2O2 generation and blunted endothelial Nox2-derived H2O2-mediated in obese rats.	Oxygen	66-69	NADPH oxidase 1	Rattus norvegicus	31-35
31563085-9	2020	Moreover, increased Nox1-derived O2.- contributed to renal endothelial dysfunction in OZR.	Oxygen	33-35	NADPH oxidase 1	Rattus norvegicus	20-24
17935347-5	2007	It is further found that compared to the oxygen gradients the EGF concentration gradients are more efficient in regulating the cell growth.	Oxygen	41-47	epidermal growth factor	Homo sapiens	62-65
31563085-10	2020	In summary, the current data support a main role for Nox1-derived O2.- in kidney vascular oxidative stress and renal endothelial dysfunction in obesity, while reduced endothelial Nox4 expression associated to decreased H2O2 generation and H2O2-mediated vasodilatation might hinder Nox4 protective renal effects thus contributing to kidney injury.	Oxygen	66-68	NADPH oxidase 1	Rattus norvegicus	53-57
31563085-10	2020	In summary, the current data support a main role for Nox1-derived O2.- in kidney vascular oxidative stress and renal endothelial dysfunction in obesity, while reduced endothelial Nox4 expression associated to decreased H2O2 generation and H2O2-mediated vasodilatation might hinder Nox4 protective renal effects thus contributing to kidney injury.	Oxygen	66-68	NADPH oxidase 4	Rattus norvegicus	281-285
17680580-1	2007	Octa-O-bis-(R,R)-Tartarate Ditellurane (SAS) is a new Te(IV) compound, comprised of two tellurium atoms, each liganded by four oxygen atoms from two carboxylates and two alkoxides of two tartaric acids.	Oxygen	127-133	tetraspanin 31	Homo sapiens	40-43
31889908-13	2019	In pancreatic cancer cells, RAD51 positively regulated cell proliferation, decreased intracellular reactive oxygen species (ROS) production and increased the HIF1alpha protein level.	Oxygen	108-114	RAD51 recombinase	Homo sapiens	28-33
17924615-2	2007	The structures of two representative nonpolar metabolites were identified earlier as dimers of 17beta-estradiol linked through a diaryl ether bond between the C-3 phenolic oxygen of one molecule and the C-2 or C-4 aromatic carbon of another.	Oxygen	172-178	complement C2	Homo sapiens	203-206
31875551-5	2019	Subsequent tolerogenic signaling induces selective phosphorylation of spleen tyrosine kinase (SYK), causing activation of NADPH oxidase-2 and moderate production of reactive oxygen species.	Oxygen	174-180	spleen tyrosine kinase	Mus musculus	70-92
31875551-5	2019	Subsequent tolerogenic signaling induces selective phosphorylation of spleen tyrosine kinase (SYK), causing activation of NADPH oxidase-2 and moderate production of reactive oxygen species.	Oxygen	174-180	spleen tyrosine kinase	Mus musculus	94-97
17924615-2	2007	The structures of two representative nonpolar metabolites were identified earlier as dimers of 17beta-estradiol linked through a diaryl ether bond between the C-3 phenolic oxygen of one molecule and the C-2 or C-4 aromatic carbon of another.	Oxygen	172-178	complement C4A (Rodgers blood group)	Homo sapiens	210-213
31870428-2	2019	Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1beta and IL-18, leading to the aggravation of the downstream inflammatory response.	Oxygen	9-15	interleukin 18	Homo sapiens	177-182
31848284-4	2019	We show that the ubiquitinated form of InlC interacts with the intracellular alarmin S100A9, resulting in its stabilization and in increased reactive oxygen species production by neutrophils in infected mice.	Oxygen	150-156	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	85-91
31915449-5	2019	We found that GS-Rb1 can reduce mPTP by stabilizing the mitochondrial membrane potential (MMP) and by reducing reactive oxygen species (ROS) during HR.	Oxygen	120-126	RB transcriptional corepressor 1	Rattus norvegicus	17-20
18028212-3	2007	In the present work, the quenching of singlet molecular oxygen, O(2)((1)Delta(g)), by DIP and RA47 and RA25 derivatives was analyzed in acetonitrile (ACN) and aqueous acid solutions.	Oxygen	56-62	RA25	Homo sapiens	103-107
31890820-7	2020	Two types of oxygen of O-1 and O-2 were observed in O1s spectrum.	Oxygen	13-19	immunoglobulin kappa variable 2D-40	Homo sapiens	23-34
31885322-7	2020	This review focuses on these aspects of cyclin D1 pathophysiology, which may be crucial for targeted therapy.Abbreviations: aa, amino acid; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin D-binding myb-like protein; DSB, double-strand DNA break; DNA-PK, DNA-dependent protein kinase; ER, estrogen receptor; FASN, fatty acid synthase; GSK3beta, glycogen synthase-3beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; HK2, hexokinase 2; HNF4alpha, and hepatocyte nuclear factor 4alpha; HR, homologous recombination; IR, ionizing radiation; KIP, kinase inhibitory protein; MCL, mantle cell lymphoma; NHEJ, non-homologous end-joining; PCAF, p300/CREB binding-associated protein; PGC1alpha, PPARgamma co-activator 1alpha; PEST, proline-glutamic acid-serine-threonine, PK, pyruvate kinase; PPAR, peroxisome proliferator-activated receptor; RB1, retinoblastoma protein; ROS, reactive oxygen species; SRC, steroid receptor coactivator; STAT, signal transducer and activator of transcription; TGFbeta, transforming growth factor beta; UPS, ubiquitin-proteasome system; USP22, ubiquitin-specific peptidase 22; XPO1 (or CRM1) exportin 1.	Oxygen	1130-1136	cyclin D1	Mus musculus	40-49
31408201-0	2020	MiR-203a-3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen-induced retinopathy (OIR) rat model via targeting VEGFA and HIF-1alpha.	Oxygen	95-101	membrane associated ring-CH-type finger 8	Rattus norvegicus	0-3
31408201-0	2020	MiR-203a-3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen-induced retinopathy (OIR) rat model via targeting VEGFA and HIF-1alpha.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	162-172
31719034-8	2019	In standard reoxygenation treated hypoxia mice, the caspase-3-dependent neuronal apoptosis was enhanced by increasing concentration of oxygen.	Oxygen	14-20	caspase 3	Mus musculus	52-61
18028212-3	2007	In the present work, the quenching of singlet molecular oxygen, O(2)((1)Delta(g)), by DIP and RA47 and RA25 derivatives was analyzed in acetonitrile (ACN) and aqueous acid solutions.	Oxygen	64-68	RA25	Homo sapiens	103-107
17611740-2	2007	OBJECTIVES: The present study evaluated the relationship between carrying the DRD4 VNTR 7-repeat allele and transient functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent responses to smoking cues among adult dependent cigarette smokers.	Oxygen	169-175	dopamine receptor D4	Homo sapiens	78-82
31835486-6	2019	The activity of the phosphatase Shp-1, which attenuates Kit activity, was reduced in Aldh2-/- mast cells, along with an increase in reactive oxygen species, known to regulate Shp-1.	Oxygen	141-147	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	32-37
31707448-3	2020	This study was to investigate the role of SOCS1 in the oxygen-glucose deprivation and reoxygenation (OGDR) or LPS-induced inflammation in microglia cell line BV-2 cells.	Oxygen	55-61	suppressor of cytokine signaling 1	Mus musculus	42-47
31835486-6	2019	The activity of the phosphatase Shp-1, which attenuates Kit activity, was reduced in Aldh2-/- mast cells, along with an increase in reactive oxygen species, known to regulate Shp-1.	Oxygen	141-147	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	175-180
17561388-4	2007	{PPI-Au/Mb}(n) films on PG electrodes demonstrated a pair of well-defined and quasi-reversible CV reduction-oxidation peaks for Mb heme Fe(III)/Fe(II) couple and good electrocatalytic properties toward reduction of oxygen and hydrogen peroxide.	Oxygen	215-221	myoglobin	Homo sapiens	8-10
31651707-0	2019	The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation.	Oxygen	81-87	sirtuin 2	Rattus norvegicus	37-46
31729000-2	2020	The O2 molecules consumed are reduced by electrons delivered by a membrane localized NADPH-oxidase that initially generate one- and two electron reduced superoxide anions (O2 -) and hydrogen peroxide (H2O2), respectively.	Oxygen	4-6	2,4-dienoyl-CoA reductase 1	Homo sapiens	85-90
31729000-2	2020	The O2 molecules consumed are reduced by electrons delivered by a membrane localized NADPH-oxidase that initially generate one- and two electron reduced superoxide anions (O2 -) and hydrogen peroxide (H2O2), respectively.	Oxygen	172-176	2,4-dienoyl-CoA reductase 1	Homo sapiens	85-90
31729001-3	2020	A consequent conformational change in NOX2 initiates the electron flow along a redox gradient, from NADPH to molecular oxygen (O2), leading to the one-electron reduction of O2 to O2  -.	Oxygen	119-125	cytochrome b-245 beta chain	Homo sapiens	38-42
17561388-4	2007	{PPI-Au/Mb}(n) films on PG electrodes demonstrated a pair of well-defined and quasi-reversible CV reduction-oxidation peaks for Mb heme Fe(III)/Fe(II) couple and good electrocatalytic properties toward reduction of oxygen and hydrogen peroxide.	Oxygen	215-221	myoglobin	Homo sapiens	128-130
31844418-0	2019	Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.	Oxygen	39-45	microRNA 376c	Homo sapiens	16-24
17652365-1	2007	Apart from enhancing red blood cell production, erythropoietin (Epo) has been shown to modulate the ventilatory response to reduced oxygen supply.	Oxygen	132-138	erythropoietin	Mus musculus	48-62
31680346-5	2019	Moreover, under hypoxia TME, the catalase-like CMS could react with endogenous H2 O2 to generate O2 for activating the catalyzed oxidation of glucose by GOx for starvation therapy accompanied with the regeneration of H2 O2 .	Oxygen	82-84	hydroxyacid oxidase 1	Homo sapiens	153-156
31819254-5	2020	This triggers Lyn/Syk-dependent calcium entry and the production of reactive oxygen species, leading to activation of caspase-8.	Oxygen	77-83	spleen associated tyrosine kinase	Homo sapiens	18-21
17652365-1	2007	Apart from enhancing red blood cell production, erythropoietin (Epo) has been shown to modulate the ventilatory response to reduced oxygen supply.	Oxygen	132-138	erythropoietin	Mus musculus	64-67
32498065-8	2020	All 3 had ill contacts in the home or had been to the pediatrician and presented with mild to moderate symptoms including fever, rhinorrhea, and hypoxia, requiring supplemental oxygen during their hospital stay.	Oxygen	177-183	paired box 5	Homo sapiens	0-5
32063958-10	2020	Pulmonary function improvement (Sa(O2) improvement rate >=5% and/or p(O2) improvement rate >=10%) was correlated with serum MMP-9 expression, baseline Sa(O2) and p(O2).	Oxygen	35-37	matrix metallopeptidase 9	Homo sapiens	124-129
32063958-10	2020	Pulmonary function improvement (Sa(O2) improvement rate >=5% and/or p(O2) improvement rate >=10%) was correlated with serum MMP-9 expression, baseline Sa(O2) and p(O2).	Oxygen	70-72	matrix metallopeptidase 9	Homo sapiens	124-129
31539522-9	2019	Surprisingly, when ischemic contracture occurred, myoglobin remained fully deoxygenated, while the cytochromes became more reduced consistent with a further, and critical, reduction of mitochondrial oxygen tension during ischemic contraction.	Oxygen	77-83	myoglobin	Mus musculus	50-59
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	156-158	proteasome 20S subunit alpha 5	Homo sapiens	342-347
32042826-10	2019	Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O2 in an arterial blood (PaO2) and fraction of inspiration O2 (FiO2) ratio, among which NLRP3, SOS1, ELF1 and STAT3 held an increasing expression in ex vivo validation while the others, PSMA5, CLEC4D, CD300A, PRKD2 and PSMA2 showed the opposite alteration from those in vivo.	Oxygen	183-185	proteasome 20S subunit alpha 5	Homo sapiens	342-347
32336186-1	2020	Several factors may affect erythropoietin (EPO) sugar structures including designing cell culture procedure, pH, concentration of additives, dissolved oxygen, and other physicochemical parameters.	Oxygen	151-157	erythropoietin	Cricetulus griseus	27-41
18021062-0	2007	The oxygenase-peroxidase theory of Bach and Chodat and its modern equivalents: change and permanence in scientific thinking as shown by our understanding of the roles of water, peroxide, and oxygen in the functioning of redox enzymes.	Oxygen	4-10	acyl-CoA thioesterase 7	Homo sapiens	35-39
32336186-1	2020	Several factors may affect erythropoietin (EPO) sugar structures including designing cell culture procedure, pH, concentration of additives, dissolved oxygen, and other physicochemical parameters.	Oxygen	151-157	erythropoietin	Cricetulus griseus	43-46
30739618-8	2020	RESULTS: Pre-treatment emotional reactivity Blood Oxygen Level-Dependent (BOLD) signal within hippocampus including CA1 predicted worse treatment outcome.	Oxygen	50-56	carbonic anhydrase 1	Homo sapiens	116-119
31823095-0	2019	LncRNA MALAT1 Promotes Oxygen-Glucose Deprivation and Reoxygenation Induced Cardiomyocytes Injury Through Sponging miR-20b to Enhance beclin1-Mediated Autophagy.	Oxygen	23-29	beclin 1	Homo sapiens	134-141
31745775-3	2019	In the present study, the salinity effect on the removal of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) from ship domestic sewage was investigated by using a novel air-lift multilevel circulation membrane reactor (AMCMBR).	Oxygen	69-75	inositol polyphosphate-5-phosphatase D	Homo sapiens	124-128
18021065-4	2007	The dramatic history of mechanistic studies of oxygen photoactivation is reviewed starting from the Bach-Engler peroxidation theory to the hypothesis of moloxide, discovery of singlet oxygen and free radicals and, then, to modern views on the primary photoactivation processes.	Oxygen	47-53	acyl-CoA thioesterase 7	Homo sapiens	100-104
17915557-5	2007	Results from each of these approaches showed that the redox status in Hsp70 cells was more reducing than that in control cells under either hypoxic or oxygen and glucose deprivation (OGD) conditions.	Oxygen	151-157	heat shock 70 kDa protein 1	Canis lupus familiaris	70-75
31446059-16	2019	SALL4 activates transcription of genes that regulate oxidative phosphorylation to increase oxygen consumption, mitochondrial membrane potential, and ATP generation in cancer cells.	Oxygen	91-97	spalt like transcription factor 4	Homo sapiens	0-5
31731100-1	2020	It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what pathways IL-35 and IL-10 could block atherogenic lipid lysophosphatidylcholine (LPC)-induced sustained EC activation; and if mitochondrial reactive oxygen species (mtROS) can differentiate mediation of EC activation from trained immunity (innate immune memory).	Oxygen	329-335	interleukin 10	Homo sapiens	78-83
31731100-1	2020	It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what pathways IL-35 and IL-10 could block atherogenic lipid lysophosphatidylcholine (LPC)-induced sustained EC activation; and if mitochondrial reactive oxygen species (mtROS) can differentiate mediation of EC activation from trained immunity (innate immune memory).	Oxygen	329-335	interleukin 10	Homo sapiens	200-205
17495954-5	2007	Here, we demonstrate that the major oxygen-dependent HIF isoforms are strongly upregulated in psoriatic skin: HIF-1alpha mainly in the epidermis, in an expression pattern similar to VEGF mRNA; HIF-2alpha in both the epidermis and in capillary endothelial cells of the dermis.	Oxygen	36-42	endothelial PAS domain protein 1	Homo sapiens	193-203
31912711-5	2019	AGERAGE interaction not only increases the generation of reactive oxygen species and inflammatory cytokines, but also activates NF-kB.	Oxygen	66-72	advanced glycosylation end-product specific receptor	Homo sapiens	0-7
31908768-7	2019	Fibroblast growth factor-23 correlated specifically to mean right atrial pressure (r = 0.67, p &lt; 0.001), six-min walking distance (r = -0.66, p &lt; 0.001), NT-proBNP (r = 0.64, p &lt; 0.001), venous oxygen saturation (r = -0.61, p &lt; 0.001), cardiac index (r = -0.39, p &lt; 0.007) and pulmonary vascular resistance (r = 0.37, p &lt; 0.01).	Oxygen	203-209	fibroblast growth factor 23	Homo sapiens	0-27
31908768-9	2019	Comparing early treatment follow-up with baseline, fibroblast growth factor-23 decreased (p &lt; 0.02), with changes in fibroblast growth factor-23 correlating to changes in six-min walking distance (r = -0.56, p &lt; 0.003), venous oxygen saturation (r = -0.46, p &lt; 0.01), pulmonary vascular resistance (r = 0.43, p &lt; 0.02), mean right atrial pressure (r = 0.38, p &lt; 0.04) and cardiac index (r = -0.39, p &lt; 0.04).	Oxygen	233-239	fibroblast growth factor 23	Homo sapiens	120-147
31678215-0	2019	Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells.	Oxygen	68-74	desmoglein 3	Canis lupus familiaris	0-12
31446614-7	2019	Hypoxia (5% O2, 5% CO2, 90% humidity) treatment for 6 h and 12 h induced HSP27, HSP32, and HSP70 expression.	Oxygen	12-14	heat shock protein 1	Mus musculus	73-78
17570486-4	2007	Using serum-containing and serum-free media culture media it was initially noted that levels of PAI-1, but not PAI-2 protein, were markedly induced by hypoxic (2-3% oxygen) treatment.	Oxygen	165-171	serpin family E member 1	Homo sapiens	96-101
31783821-16	2019	These effects were blocked by the reactive oxygen species scavenger NAC or the Akt activator SC79, while the PI3K inhibitor LY294002 or the Akt inhibitor triciribine enhanced these effects.	Oxygen	43-49	X-linked Kx blood group	Homo sapiens	68-71
31784833-4	2019	If glucose oxidase (GOx) catalyzes the oxidation of glucose, dissolved oxygen is consumed.	Oxygen	71-77	hydroxyacid oxidase 1	Homo sapiens	3-18
31784833-4	2019	If glucose oxidase (GOx) catalyzes the oxidation of glucose, dissolved oxygen is consumed.	Oxygen	71-77	hydroxyacid oxidase 1	Homo sapiens	20-23
31886226-7	2019	Concentrations of reactive oxygen species and MDA content increased in splenocytes during T-2 toxin treatments, whereas activities of SOD, CAT, and GSH-PX decreased.	Oxygen	27-33	solute carrier family 25 member 5	Homo sapiens	90-93
31611307-7	2019	N-acetyl-L-cysteine and mito-TEMPO blocked the induction of IL-1beta by inhibiting reactive oxygen species (ROS) with SAA treatment.	Oxygen	92-98	serum amyloid A cluster	Mus musculus	118-121
31881642-6	2019	Genetic knockdown of OPA3 caused a significant decrease of energy metabolism, manifested by a suppression of oxygen consumption rate (OCR) and a decrease in cellular ATP content, leading to inhibition of cell proliferation capacity and reduced expression of epithelial-mesenchymal transition (EMT) markers.	Oxygen	109-115	outer mitochondrial membrane lipid metabolism regulator OPA3	Homo sapiens	21-25
31858290-12	2019	In vitro results show that 64Cu-ATSM showed an increase in the uptake only in severe hypoxia at 0.5 and 0.2% of oxygen while for 64Cu-Cl2, the cell retention was significantly increased at 5% and 1% of oxygen with no significant rise at lower oxygen percentages.	Oxygen	202-208	endogenous retrovirus group W member 5	Homo sapiens	134-137
31858290-12	2019	In vitro results show that 64Cu-ATSM showed an increase in the uptake only in severe hypoxia at 0.5 and 0.2% of oxygen while for 64Cu-Cl2, the cell retention was significantly increased at 5% and 1% of oxygen with no significant rise at lower oxygen percentages.	Oxygen	202-208	endogenous retrovirus group W member 5	Homo sapiens	134-137
31775504-8	2019	By a careful geometric analysis of the oxygen pockets near the substrate binding cleft, the present study identifies the launching sites for oxygenation at the prochiral carbon centers C8, C11, C12, and C15 and the stereochemistry (R/S) of the corresponding products.	Oxygen	39-45	RNA polymerase III subunit K	Homo sapiens	189-192
31775504-8	2019	By a careful geometric analysis of the oxygen pockets near the substrate binding cleft, the present study identifies the launching sites for oxygenation at the prochiral carbon centers C8, C11, C12, and C15 and the stereochemistry (R/S) of the corresponding products.	Oxygen	39-45	placenta associated 8	Homo sapiens	203-206
31746191-1	2019	Multiscale simulations have been performed to address the longstanding issue of the "dioxygen activation" by the binucle-ar copper monooxygenases (PHM and DbetaM), which were traditionally classified as the "noncoupled" binuclear copper enzymes.	Oxygen	85-93	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	147-150
17570486-9	2007	Our findings provide insight into the physiological regulation of trophoblast PAI-1 expression in early pregnancy when placental oxygen levels are low, as well as a mechanism for over-expression of placental PAI-1 noted in pregnancies with preeclampsia.	Oxygen	129-135	serpin family E member 1	Homo sapiens	78-83
31670933-6	2019	Mass ratios of MSA to nss-SO42- increased firstly and then decreased with the temperature from -10 to 5 oC, with a maximum value occurred at the temperature of -3 oC.	Oxygen	104-106	thyroid peroxidase	Homo sapiens	15-18
17705494-1	2007	Complexing an iron protoporphyrin IX into a genetically engineered heme pocket of recombinant human serum albumin (rHSA) generates an artificial hemoprotein, which can bind O2 in much the same way as hemoglobin (Hb).	Oxygen	173-175	CD24 molecule	Rattus norvegicus	115-119
31670933-6	2019	Mass ratios of MSA to nss-SO42- increased firstly and then decreased with the temperature from -10 to 5 oC, with a maximum value occurred at the temperature of -3 oC.	Oxygen	163-165	thyroid peroxidase	Homo sapiens	15-18
31708690-7	2019	Then, we found that overexpression of p62 promoted glioma progression by promoting proliferation, migration, glycolysis, temozolomide (TMZ) resistance and nuclear factor kappaB (NF-kappaB) signalling pathway, and repressing autophagic flux and reactive oxygen species (ROS) in vitro.	Oxygen	253-259	nucleoporin 62	Homo sapiens	38-41
31841528-2	2019	Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species of adult and neonatal CD8+ T cells on their activation potential.	Oxygen	90-96	CD8a molecule	Homo sapiens	127-130
17705494-6	2007	Several substitutions were severely detrimental to O2 binding: for example, Gln-185, His-185, and His-182 all generated a weak six-coordinate heme, while the rHSA(HF/R186H)-heme complex possessed a typical bis-histidyl hemochrome that was immediately autoxidized by O2.	Oxygen	51-53	CD24 molecule	Rattus norvegicus	158-162
31836786-4	2019	Here we observed that melatonin increases the expression of Bmal1 and both melatonin and Bmal1 increase cellular survival after oxygen glucose deprivation (OGD) while the inhibition of Bmal1 resulted in the decreased cellular survival without affecting neuroprotective effects of melatonin.	Oxygen	128-134	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	60-65
17705494-6	2007	Several substitutions were severely detrimental to O2 binding: for example, Gln-185, His-185, and His-182 all generated a weak six-coordinate heme, while the rHSA(HF/R186H)-heme complex possessed a typical bis-histidyl hemochrome that was immediately autoxidized by O2.	Oxygen	266-268	CD24 molecule	Rattus norvegicus	158-162
31836786-4	2019	Here we observed that melatonin increases the expression of Bmal1 and both melatonin and Bmal1 increase cellular survival after oxygen glucose deprivation (OGD) while the inhibition of Bmal1 resulted in the decreased cellular survival without affecting neuroprotective effects of melatonin.	Oxygen	128-134	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	89-94
31836786-4	2019	Here we observed that melatonin increases the expression of Bmal1 and both melatonin and Bmal1 increase cellular survival after oxygen glucose deprivation (OGD) while the inhibition of Bmal1 resulted in the decreased cellular survival without affecting neuroprotective effects of melatonin.	Oxygen	128-134	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	89-94
31430465-0	2019	The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.	Oxygen	49-55	microRNA let-7b	Homo sapiens	107-113
17705494-7	2007	In marked contrast, HSA(HL/L185N)-heme showed very high O2 binding affinity (P1/2O2 1 Torr, 22 degrees C), which is 18-fold greater than that of the original double mutant rHSA(HL)-heme and very close to the affinities exhibited by myoglobin and the high-affinity form of Hb.	Oxygen	56-58	CD24 molecule	Rattus norvegicus	20-23
31430465-8	2019	OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization.	Oxygen	154-160	insulin like growth factor 1 receptor	Homo sapiens	31-36
17705494-7	2007	In marked contrast, HSA(HL/L185N)-heme showed very high O2 binding affinity (P1/2O2 1 Torr, 22 degrees C), which is 18-fold greater than that of the original double mutant rHSA(HL)-heme and very close to the affinities exhibited by myoglobin and the high-affinity form of Hb.	Oxygen	56-58	CD24 molecule	Rattus norvegicus	172-176
31430465-8	2019	OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization.	Oxygen	154-160	microRNA let-7b	Homo sapiens	73-79
31570981-7	2019	In vitro and animal data have shown that induction of reactive oxygen species (ROS) and oxidative stress plays a critical role during T-2 toxin-induced neurotoxicity.	Oxygen	63-69	solute carrier family 25 member 5	Homo sapiens	134-137
31487223-2	2019	Vascular endothelial growth factor (VEGF) regulates oxygen delivery through angiogenesis, capillary maintenance, and contraction-induced perfusion.	Oxygen	52-58	vascular endothelial growth factor A	Mus musculus	0-34
33423492-4	2019	Monolayer cultures under low oxygen conditions exhibited increased expression of hypoxia-related genes such as VEGF, CAIX, and GLUT1.	Oxygen	29-35	solute carrier family 2 member 1	Homo sapiens	127-132
31801113-1	2019	As a classic immunoregulatory cytokine, interleukin-10 (IL-10) can provide in vivo and in vitro neuroprotection respectively during cerebral ischemia and after the oxygen-glucose deprivation (OGD)-induced injury.	Oxygen	164-170	interleukin 10	Homo sapiens	40-54
31801113-1	2019	As a classic immunoregulatory cytokine, interleukin-10 (IL-10) can provide in vivo and in vitro neuroprotection respectively during cerebral ischemia and after the oxygen-glucose deprivation (OGD)-induced injury.	Oxygen	164-170	interleukin 10	Homo sapiens	56-61
31816825-0	2019	Ginsenosides Rb1 and Rg1 Protect Primary Cultured Astrocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Improving Mitochondrial Function.	Oxygen	69-75	RB transcriptional corepressor 1	Mus musculus	13-16
31816825-1	2019	This study aimed to evaluate whether ginsenosides Rb1 (20-S-protopanaxadiol aglycon) and Rg1 (20-S-protopanaxatriol aglycon) have mitochondrial protective effects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in primary mouse astrocytes and to explore the mechanisms involved.	Oxygen	171-185	RB transcriptional corepressor 1	Mus musculus	50-53
31487223-2	2019	Vascular endothelial growth factor (VEGF) regulates oxygen delivery through angiogenesis, capillary maintenance, and contraction-induced perfusion.	Oxygen	52-58	vascular endothelial growth factor A	Mus musculus	36-40
17397983-3	2007	Its activation depends on the interaction with cytosolic regulatory proteins (p67-phox, p47-phox, p40-phox and Rac) leading to an electron transfer from NADPH to molecular oxygen and to the release of superoxide anions.	Oxygen	172-178	neutrophil cytosolic factor 4	Homo sapiens	98-114
30841739-2	2019	For some BGMS using glucose oxidase (GOx)-based test strips, one of these factors is the oxygen partial pressure (pO2) of the applied blood sample.	Oxygen	89-95	hydroxyacid oxidase 1	Homo sapiens	20-35
30841739-2	2019	For some BGMS using glucose oxidase (GOx)-based test strips, one of these factors is the oxygen partial pressure (pO2) of the applied blood sample.	Oxygen	89-95	hydroxyacid oxidase 1	Homo sapiens	37-40
31810306-5	2019	On the one hand, overexpression of MaATG8f activated the activities of superoxide dismutase, catalase, and peroxidase under drought stress conditions, so as to regulate reactive oxygen species accumulation.	Oxygen	178-184	peroxidase 24	Musa acuminata	107-117
17007961-3	2007	NtGRAS1 expression was strongly induced in tobacco (BY-2) suspension cells by antimycin A, H(2)O(2), salicylic acid, and L-cysteine which were all found to raise intracellular reactive oxygen levels.	Oxygen	185-191	scarecrow-like protein 14	Nicotiana tabacum	0-7
31738019-3	2019	The subsequent in vitro investigations reveal that the PIGH NPs afford uniform particle size, sustained drug release profile, strong longitudinal relaxivity, potent photothermal effect, effective singlet oxygen generation, and ideal resistance to photobleaching.	Oxygen	204-210	phosphatidylinositol glycan anchor biosynthesis, class H	Mus musculus	55-59
31738019-4	2019	Moreover, the PIGH NPs achieve high cellular uptake, efficient cytoplasmic drug translocation based on singlet oxygen-triggered endolysosomal disruption and prominent cytotoxicity effect against 4T1 cells under 808 nm near-infrared (NIR) irradiation in contrast to PTX/ICG-loaded HSA nanoparticles (PIH NPs) and free PTX/ICG.	Oxygen	111-117	phosphatidylinositol glycan anchor biosynthesis, class H	Mus musculus	14-18
31529142-9	2019	A combination of both VAS1 variant alleles in a diploid yeast cell exhibited a more significant decrease in oxidative metabolism-dependent growth and in the oxygen consumption rate (reminiscent of the patient who carries two mutant VARS2 alleles).	Oxygen	157-163	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	232-237
17007961-3	2007	NtGRAS1 expression was strongly induced in tobacco (BY-2) suspension cells by antimycin A, H(2)O(2), salicylic acid, and L-cysteine which were all found to raise intracellular reactive oxygen levels.	Oxygen	185-191	F-box protein PP2-B11-like	Nicotiana tabacum	52-56
31470043-8	2019	Stimulation of parasympathetic nervous system by injection of CNO (1 mg/kg) increased oxygen consumption and energy expenditure.	Oxygen	86-92	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino	Mus musculus	62-65
31550180-4	2019	When HrH4 expression was knocked down in the subcutaneous white adipose tissue (scWAT), browning and lipolysis effects triggered by cold were ablated, and the oxygen consumption was also lowered both at the normal and cold conditions.	Oxygen	159-165	histamine receptor H4	Mus musculus	5-9
17370314-2	2007	Inhibition of adipogenesis at low oxygen tension is associated with activation of hypoxia inducible factor-1 alpha (HIF-1alpha), a transcription factor essential for cellular responses to decreased oxygen levels whose activity is regulated by prolyl hydroxylase (PHD) enzymes.	Oxygen	34-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	82-114
31890910-7	2019	Over expression of HSP70 has been observed under oxidative stress leading to scavenging of mitochondrial reactive oxygen species and protection of pulmonary endothelial barrier against bacterial toxins.	Oxygen	114-120	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-24
31573398-10	2019	Oxygen inhalation generated lung signal enhancement of 19% +- 11 (standard deviation) at 0.55 T compared with 7.6% +- 6.3 at 1.5 T (P = .02; five participants) because of the increased T1 relaxivity of oxygen (4.7e-4 mmHg-1sec-1).	Oxygen	0-6	secretory blood group 1, pseudogene	Homo sapiens	223-228
17370314-2	2007	Inhibition of adipogenesis at low oxygen tension is associated with activation of hypoxia inducible factor-1 alpha (HIF-1alpha), a transcription factor essential for cellular responses to decreased oxygen levels whose activity is regulated by prolyl hydroxylase (PHD) enzymes.	Oxygen	34-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-126
31779421-5	2019	Oxygen and carbon dioxide gases are used to produce O- and O2 - ion beams, and ion composition is analyzed by using a Wien filter.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	52-61
31560926-8	2019	In cultured HRECs, PRP-Exos induced the production of malonyldialdehyde(MDA) and reactive oxygen species(ROS) and inhibited the activity of superoxide dismutase(SOD).	Oxygen	90-96	proline rich protein 2-like 1	Rattus norvegicus	19-22
17370314-2	2007	Inhibition of adipogenesis at low oxygen tension is associated with activation of hypoxia inducible factor-1 alpha (HIF-1alpha), a transcription factor essential for cellular responses to decreased oxygen levels whose activity is regulated by prolyl hydroxylase (PHD) enzymes.	Oxygen	198-204	hypoxia inducible factor 1, alpha subunit	Mus musculus	82-114
17370314-2	2007	Inhibition of adipogenesis at low oxygen tension is associated with activation of hypoxia inducible factor-1 alpha (HIF-1alpha), a transcription factor essential for cellular responses to decreased oxygen levels whose activity is regulated by prolyl hydroxylase (PHD) enzymes.	Oxygen	198-204	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-126
30661173-2	2019	We, therefore, investigated the role of NADPH oxidase derived O2.--mediated modulation of MMP2-sphingomyeline-ceramide-S1P signalling axis in ET-1 induced increase in proliferation of PASMCs.	Oxygen	62-64	endothelin 1	Bos taurus	142-146
31827279-4	2019	Oncogenic KRAS alters the metabolism of tumour cells3 in several ways, including increased glucose uptake and glycolysis even in the presence of abundant oxygen4 (the Warburg effect).	Oxygen	154-161	KRAS proto-oncogene, GTPase	Homo sapiens	10-14
31551038-8	2019	Calcium signals induced by calcium store depletion or oxygen/glucose deprivation were significantly diminished in Orai2-deficient neurons demonstrating that Orai2 is a central mediator of neuronal capacitative Ca2+ entry and is involved in calcium overload during ischemia.	Oxygen	54-60	ORAI calcium release-activated calcium modulator 2	Mus musculus	114-119
31551038-8	2019	Calcium signals induced by calcium store depletion or oxygen/glucose deprivation were significantly diminished in Orai2-deficient neurons demonstrating that Orai2 is a central mediator of neuronal capacitative Ca2+ entry and is involved in calcium overload during ischemia.	Oxygen	54-60	ORAI calcium release-activated calcium modulator 2	Mus musculus	157-162
17584830-2	2007	Here we demonstrate that sEpoR, a negative regulator of Epo"s binding to the EpoR, is present in the mouse brain and is down-regulated by 62% after exposure to normobaric chronic hypoxia (10% O2 for 3 days).	Oxygen	192-194	erythropoietin	Mus musculus	26-29
31747128-1	2019	Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.	Oxygen	63-69	hydroxyacid oxidase 1	Homo sapiens	0-15
31747128-1	2019	Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.	Oxygen	63-69	hydroxyacid oxidase 1	Homo sapiens	17-20
31279089-6	2019	adTrx1 and adTrxR1 significantly reduced the increases in O2 - level in H2O2-treated HPASM cells at 24 h. Furthermore, HPASM cells transfected with Trx1 or TrxR1 siRNA showed increases in ROS levels with or without H2O2 at 5 min.	Oxygen	58-62	thioredoxin reductase 1	Homo sapiens	13-18
17584830-2	2007	Here we demonstrate that sEpoR, a negative regulator of Epo"s binding to the EpoR, is present in the mouse brain and is down-regulated by 62% after exposure to normobaric chronic hypoxia (10% O2 for 3 days).	Oxygen	192-194	erythropoietin receptor	Mus musculus	26-30
17584830-4	2007	These observations imply that hypoxic downregulation of sEpoR is required for adequate ventilatory acclimatization to hypoxia, thereby underlying the function of Epo as a key factor regulating oxygen delivery not only by its classical activity on red blood cell production, but also by regulating ventilation.	Oxygen	193-199	erythropoietin	Mus musculus	57-60
17667573-0	2007	The novel hemoglobin-based oxygen carrier HRC 101 improves survival in murine sickle cell disease.	Oxygen	27-33	histidine rich calcium binding protein	Mus musculus	42-45
31776798-4	2019	TYR catalyzes the oxidation of DA while CAT can decompose H2O2 into water and oxygen.	Oxygen	78-84	tyrosinase	Homo sapiens	0-3
17667573-3	2007	The authors tested the hypothesis that the novel hemoglobin-based oxygen carrier, HRC 101, would improve survival during exposure to acute hypoxia in a murine model of sickle cell disease, the transgenic mouse expressing hemoglobin SAD (alpha2beta2).	Oxygen	66-72	histidine rich calcium binding protein	Mus musculus	82-85
31598687-6	2019	In the dek40 mutant, abolishment of the C-to-U editing of cox3-314, nad2-26, and nad5-1916 leads to accumulated reactive oxygen species and promoted programmed cell death in endosperm cells due to the dysfunction of mitochondrial complexes I and IV.	Oxygen	121-127	NADH dehydrogenase 2	Zea mays	68-72
17667573-10	2007	HRC 101 significantly increased survival in SAD mice breathing 6% oxygen.	Oxygen	66-72	histidine rich calcium binding protein	Mus musculus	0-3
17573505-4	2007	A simple oxygen mask was fitted to the HPS in the normal fashion.	Oxygen	9-15	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	39-42
31545178-5	2019	Microaerophilic treatment of RTE by enriched bacterial community DR4, in the presence of optimized electron donor (sucrose) and nitrogen source (yeast extract) resulted in 88% of American Dye Manufacturer"s Institute (ADMI) removal and 98% of Chemical oxygen demand (COD) reduction within 32 h at 37  C. In silico prediction of the functional genes within bacterial community DR4 was made by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis.	Oxygen	252-258	major histocompatibility complex, class II, DR beta 4	Homo sapiens	65-68
17553943-0	2007	Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.	Oxygen	99-105	carbonic anhydrase 1	Rattus norvegicus	33-36
17553943-2	2007	This study tests the hypothesis that hyperoxic superfusate (95% O(2)) causes a time-dependent increase in superoxide anion (*O(2)(-)) production in CA1 neurons in slices, which will decrease as oxygen concentration is decreased.	Oxygen	194-200	carbonic anhydrase 1	Rattus norvegicus	148-151
31723053-5	2019	Ischemia-induced NADH elevation in the cortex indicated prolonged production of reactive oxygen species by xanthine oxidase (XOD).	Oxygen	89-95	xanthine dehydrogenase	Mus musculus	107-123
17553943-8	2007	We conclude that .O(2)(-) production and cell death in CA1 neurons increases in response to increasing oxygen concentration product (= PO(2) x time).	Oxygen	103-109	carbonic anhydrase 1	Rattus norvegicus	55-58
17693530-11	2007	ZTL contains a Light-Oxygen-Voltage domain, and its activity may be directly regulated by blue light.	Oxygen	21-27	Galactose oxidase/kelch repeat superfamily protein	Arabidopsis thaliana	0-3
31575661-1	2019	Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the Gi/o protein-coupled kappa opioid receptor (KOR), mu opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS).	Oxygen	249-255	opioid receptor kappa 1	Homo sapiens	116-137
31575661-1	2019	Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the Gi/o protein-coupled kappa opioid receptor (KOR), mu opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS).	Oxygen	249-255	opioid receptor kappa 1	Homo sapiens	139-142
31697685-0	2019	Correction: KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species.	Oxygen	70-76	KRIT1 ankyrin repeat containing	Homo sapiens	12-17
17567017-4	2007	Pentamidine, a bivalent aromatic diamidine, interacts with QacR differently as one positively charged benzamidine moiety is neutralized by the dipoles of side-chain and peptide backbone oxygens rather than a formal negative charge from proximal acidic residues.	Oxygen	186-193	QacR	Staphylococcus aureus	59-63
31754421-1	2019	Methemoglobin (MetHb) is an oxidized form on hemoglobin, which is unable to bind oxygen and consequently carry it to the tissues.	Oxygen	81-87	hemoglobin subunit gamma 2	Homo sapiens	0-13
31754421-1	2019	Methemoglobin (MetHb) is an oxidized form on hemoglobin, which is unable to bind oxygen and consequently carry it to the tissues.	Oxygen	81-87	hemoglobin subunit gamma 2	Homo sapiens	15-20
31494508-7	2019	This is the first report on application of functionalized PIL to reveal the O2 - related pathological process of AD.	Oxygen	76-78	serpin family A member 2 (gene/pseudogene)	Homo sapiens	58-61
17584476-2	2007	The feasibility of myoglobin (Mb)-facilitated oxygen transport in improving porcine islet survival under hypoxia was investigated.	Oxygen	46-52	myoglobin	Homo sapiens	19-28
17584476-2	2007	The feasibility of myoglobin (Mb)-facilitated oxygen transport in improving porcine islet survival under hypoxia was investigated.	Oxygen	46-52	myoglobin	Homo sapiens	30-32
17481694-8	2007	Generation of 3-OH-B(a)P in group II implicates the possibility of reactive oxygen species (O2- and H2O2) production in haemolysates during cytochrome P4501A1 (CYP1A1) mediated Phase-I-metabolism.	Oxygen	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-158
17498968-4	2007	This was reversed by noggin at 5%, but not 20%, oxygen due to a novel repressive effect of low oxygen on bone morphogenetic protein (BMP) signaling.	Oxygen	95-101	bone morphogenetic protein 1	Homo sapiens	105-131
17498968-4	2007	This was reversed by noggin at 5%, but not 20%, oxygen due to a novel repressive effect of low oxygen on bone morphogenetic protein (BMP) signaling.	Oxygen	95-101	bone morphogenetic protein 1	Homo sapiens	133-136
17331710-6	2007	The frequency of ever smoking in Sweden in the age group receiving oxygen, i.e. age 65-84 years, was 36.4% in women and 65.0% in men, indicating that women ran a higher risk of developing an oxygen-requiring chronic hypoxaemia.	Oxygen	67-73	RAN, member RAS oncogene family	Homo sapiens	156-159
17331710-6	2007	The frequency of ever smoking in Sweden in the age group receiving oxygen, i.e. age 65-84 years, was 36.4% in women and 65.0% in men, indicating that women ran a higher risk of developing an oxygen-requiring chronic hypoxaemia.	Oxygen	191-197	RAN, member RAS oncogene family	Homo sapiens	156-159
17567755-3	2007	IGFBP3-expressing plasmid was injected into the vitreous of neonatal mice undergoing the oxygen-induced retinopathy (OIR) model.	Oxygen	89-95	insulin-like growth factor binding protein 3	Mus musculus	0-6
17567756-0	2007	IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.	Oxygen	53-59	insulin like growth factor binding protein 3	Homo sapiens	0-6
17567756-3	2007	Here we define insulin-like growth factor binding protein-3 (IGFBP3) as a new modulator of vascular survival and regrowth in oxygen-induced retinopathy.	Oxygen	125-131	insulin like growth factor binding protein 3	Homo sapiens	15-59
17567756-3	2007	Here we define insulin-like growth factor binding protein-3 (IGFBP3) as a new modulator of vascular survival and regrowth in oxygen-induced retinopathy.	Oxygen	125-131	insulin like growth factor binding protein 3	Homo sapiens	61-67
17567756-4	2007	In IGFBP3-deficient mice, there was a dose-dependent increase in oxygen-induced retinal vessel loss.	Oxygen	65-71	insulin-like growth factor binding protein 3	Mus musculus	3-9
17567756-5	2007	Subsequent to oxygen-induced retinal vessel loss, Igfbp3(-/-) mice had a 31% decrease in retinal vessel regrowth versus controls after returning to room air.	Oxygen	14-20	insulin-like growth factor binding protein 3	Mus musculus	50-56
17567756-11	2007	These results suggest that IGFBP3, acting independently of IGF1, helps to prevent oxygen-induced vessel loss and to promote vascular regrowth after vascular destruction in vivo in a dose-dependent manner, resulting in less retinal neovascularization.	Oxygen	82-88	insulin like growth factor binding protein 3	Homo sapiens	27-33
17350247-7	2007	FTIR study confirmed the complexation between Cu(II)-MIIP and Cu(II) metal ion through carbonyl oxygen of acryl amide.	Oxygen	96-102	migration and invasion inhibitory protein	Homo sapiens	53-57
31627696-3	2007	In the follicular phase of a menstrual cycle, leptin suppressed phagocytic activity when used in a low dose (10 ng/ ml) and reduced the monocytic production of active oxygen forms when used in the high dose in the induced luminol-dependent chemiluminescence (LDC).	Oxygen	167-173	leptin	Homo sapiens	46-52
31627696-4	2007	In the luteinlc phase, Leptin (10 and 35 ng/ml) exerted a stimulating effect on monocytic phagocytosis, but substantially decreased the extracellular production of active oxygen metabolites in LDC.	Oxygen	171-177	leptin	Homo sapiens	23-29
17506535-0	2007	Mechanism of OH radical reactions with HCN and CH3CN: OH regeneration in the presence of O2.	Oxygen	89-91	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	39-42
17506535-1	2007	A theoretical study on the mechanism of the OH reactions with HCN and CH(3)CN, in the presence of O2, is presented.	Oxygen	98-100	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	62-65
17512623-12	2007	OPN was up regulated at low oxygen in SiHa cells, but was not induced by hypoxia in FaDu(DD) cells.	Oxygen	28-34	secreted phosphoprotein 1	Homo sapiens	0-3
31450287-9	2019	The results may implicate the future investigations and development of a new generation of rocket engines, which also feature the possibility of re-ignition while in orbit - understanding and predicting of cavitation behaviour is becoming a crucial part at the (liquid oxygen - LOX and liquid hydrogen - LH2) turbo-pump design.	Oxygen	269-275	lysyl oxidase	Homo sapiens	278-281
17360721-3	2007	In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chaperone, suppresses mutant huntingtin-induced reactive oxygen species formation and cell death.	Oxygen	131-137	heat shock protein family B (small) member 1	Homo sapiens	48-53
31450350-6	2019	The investigation on the sample structures and active oxygen species demonstrated that the highly active O2- species generated from HCO4- of NaHCO3-H2O2 acted preferentially on the GalA backbone in the HG region, while the RG-I region was maintained; and ultrasound enhanced the degradation efficiency via both chemical effects (increasing the transformation of free radicals) and mechanical effects (disaggregating polysaccharide clusters).	Oxygen	54-60	galactosidase alpha	Homo sapiens	181-185
31450350-6	2019	The investigation on the sample structures and active oxygen species demonstrated that the highly active O2- species generated from HCO4- of NaHCO3-H2O2 acted preferentially on the GalA backbone in the HG region, while the RG-I region was maintained; and ultrasound enhanced the degradation efficiency via both chemical effects (increasing the transformation of free radicals) and mechanical effects (disaggregating polysaccharide clusters).	Oxygen	105-107	galactosidase alpha	Homo sapiens	181-185
17360721-3	2007	In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chaperone, suppresses mutant huntingtin-induced reactive oxygen species formation and cell death.	Oxygen	131-137	huntingtin	Mus musculus	103-113
31736997-9	2019	Yeast one-hybrid (Y1H) assays and electrophoretic mobility shift assays (EMSAs) revealed that GhWRKY91 directly targets GhWRKY17, a gene associated with ABA signals and reactive oxygen species (ROS) production.	Oxygen	178-184	probable WRKY transcription factor 65	Gossypium hirsutum	94-102
17309061-7	2007	PEDF production by Muller cells is not only regulated by retinal oxygen but also by the activity of soluble factors released from retinal endothelial cells.	Oxygen	65-71	LOC100337325	Bos taurus	0-4
31897286-9	2019	The results suggest that the mechanism of radiation induced RIGI in HF19 cells can be correlated with the induction of reactive oxygen species levels following exposure to 0.1 and 1 Gy low-dose rate and high-dose rate x-ray irradiation.	Oxygen	128-134	DExD/H-box helicase 58	Homo sapiens	60-64
17055654-7	2007	Increased levels of p21 can result in growth inhibition, reduced repair from the p21-PCNA interaction, and increased generation of reactive oxygen.	Oxygen	140-146	H3 histone pseudogene 16	Homo sapiens	20-23
17311330-6	2007	IL-6, MIP-1alpha, and G-CSF were negatively correlated with O2 saturation during RSV infection.	Oxygen	60-62	C-C motif chemokine ligand 3	Homo sapiens	6-16
17311330-6	2007	IL-6, MIP-1alpha, and G-CSF were negatively correlated with O2 saturation during RSV infection.	Oxygen	60-62	colony stimulating factor 3	Homo sapiens	22-27
17356087-8	2007	There was a trend for a relationship between mean oxygen desaturation &lt; 90% and PAI-1 (p = 0.053), even after controlling for AHI.	Oxygen	50-56	serpin family E member 1	Homo sapiens	83-88
17120015-0	2007	PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue.	Oxygen	38-44	cAMP responsive element binding protein 1	Rattus norvegicus	19-23
31762758-4	2019	G6PD enzyme is crucial in preventing damage to cellular structures caused by oxygen-free radicles.	Oxygen	77-83	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
31762758-5	2019	In G6PD deficiency the hemolysis is mediated through the oxidative stress created by oxygen-free radicles.	Oxygen	85-91	glucose-6-phosphate dehydrogenase	Homo sapiens	3-7
17120015-4	2007	CREB is activated in parallel to HIF-1alpha nuclear translocation in the young after hypoxia exposure followed by reoxygenation, while this kind of response is not so dramatic in the old, neither in terms of CREB activation, neither in terms of HIF-1alpha expression and translocation, suggesting in the old the existence of an impaired oxygen-sensing mechanism or an adaptation of the cells to hypoxia.	Oxygen	116-122	cAMP responsive element binding protein 1	Rattus norvegicus	0-4
31444514-0	2019	Anti-angiogenic and anti-inflammatory effects of CD200-CD200R1 axis in oxygen-induced retinopathy mice model.	Oxygen	71-77	CD200 receptor 1	Mus musculus	55-62
17234685-1	2007	D-aspartate oxidase (DDO, EC 1.4.3.1) catalyzes dehydrogenation of D-aspartate to iminoaspartate and the subsequent re-oxidation of reduced FAD with O2 to produce hydrogen peroxide.	Oxygen	149-151	D-aspartate oxidase	Homo sapiens	21-24
17217981-3	2007	Of the biomass characteristics studied, only solids concentration (correlated with viscosity), the carbohydrate fraction of the EPS (EPS(c)) and the chemical oxygen demand (COD) concentration of the SMP (SMP(COD)) were found to affect the oxygen transfer parameters k(L)a(20) (the oxygen transfer coefficient) and alpha-factor.	Oxygen	239-245	family with sequence similarity 53 member B	Homo sapiens	199-202
31541352-6	2019	Specific inhibition of PKCgamma and PKCepsilon significantly attenuated OGD induced cytotoxicity, rise in intracellular calcium, membrane depolarization and reactive oxygen species formation, thereby enhancing neuronal viability.	Oxygen	166-172	protein kinase C, gamma	Rattus norvegicus	23-31
17291539-0	2007	Preconditioning with hyperbaric oxygen induces tolerance against oxidative injury via increased expression of heme oxygenase-1 in primary cultured spinal cord neurons.	Oxygen	32-38	heme oxygenase 1	Homo sapiens	110-126
31386893-6	2019	The ANP secretion increased negatively correlated with O2 tension.	Oxygen	55-57	natriuretic peptide A	Rattus norvegicus	4-7
31493869-4	2019	By investigating an in vitro model, we reveal that REDD1 is induced by HIF-1alpha in H9c2 cells subjected to oxygen/glucose deprivation followed by reperfusion (OGD/R).	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	71-81
17314340-8	2007	All mutant BCS1L proteins disrupted the assembly of complex III, reduced the activity of the mitochondrial electron-transport chain, and increased the production of reactive oxygen species.	Oxygen	174-180	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	11-16
31482682-2	2019	This one-pot procedure utilizes arenophile chemistry, and the corresponding para-cycloadducts are treated with oxygen nucleophiles via formal allylic substitution, providing direct access to syn-1,4-oxyaminated products.	Oxygen	111-117	synapsin I	Homo sapiens	191-196
31731530-4	2019	Moreover, HSP also enhances membrane stability and detoxifies the reactive oxygen species (ROS) by positively regulating the antioxidant enzymes system.	Oxygen	75-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
17314340-11	2007	All BCS1L mutations disrupted the assembly of mitochondrial respirasomes (the basic unit for respiration in human mitochondria), but the clinical expression of the mutations was correlated with the production of reactive oxygen species.	Oxygen	221-227	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	4-9
17295437-0	2007	Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.	Oxygen	13-19	interleukin 1 alpha	Homo sapiens	31-44
17295437-8	2007	RESULTS: IL-1-induced peroxynitrite formation was decreased in 1% O2 as compared to 20% O2.	Oxygen	66-68	interleukin 1 alpha	Homo sapiens	9-13
31681379-10	2019	At a moderate growth light intensity (50 micromol photons m-2 s-1), AtLQY1-expressing Synechocystis was found to have significantly higher F v /F m , and lower nonphotochemical quenching and reactive oxygen species levels than the empty-vector control, which is opposite from the loss-of-function Atlqy1 mutant phenotype.	Oxygen	200-206	DnaJ/Hsp40 cysteine-rich domain superfamily protein	Arabidopsis thaliana	68-74
17295437-8	2007	RESULTS: IL-1-induced peroxynitrite formation was decreased in 1% O2 as compared to 20% O2.	Oxygen	88-90	interleukin 1 alpha	Homo sapiens	9-13
17295437-9	2007	MnTE-2-PyP5+ inhibited IL-1-induced peroxynitrite formation in either 1% O2 or 20% O2.	Oxygen	73-75	interleukin 1 alpha	Homo sapiens	23-27
17295437-9	2007	MnTE-2-PyP5+ inhibited IL-1-induced peroxynitrite formation in either 1% O2 or 20% O2.	Oxygen	83-85	interleukin 1 alpha	Homo sapiens	23-27
17295437-10	2007	In 1% O2 (but not in 20% O2), Mn porphyrin significantly inhibited IL-1-induced proteoglycan degradation.	Oxygen	6-8	interleukin 1 alpha	Homo sapiens	67-71
31126732-2	2019	Several lines of evidence support a role for oxidative stress in atherogenesis and NADPH oxidase-2 (NOX-2) is considered a major source of O2- in human.	Oxygen	139-142	cytochrome b-245 beta chain	Homo sapiens	83-98
16924414-3	2007	In this study, we determined that mitochondrial uncouplers, rottlerin and FCCP, significantly decreased hypoxic as well as normoxic HIF-1 transcriptional activity which was in part mediated by down-regulation of the oxygen labile HIF-1alpha and HIF-2alpha protein levels in PC-3 and DU-145 prostate cancer cells.	Oxygen	216-222	endothelial PAS domain protein 1	Homo sapiens	245-255
31469718-6	2019	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and lactate dehydrogenase assay were used to prove that knockdown small nucleolar RNA host gene 12 reduced cell viability after oxygen-glucose deprivation/reoxygen treatment.	Oxygen	203-209	small nucleolar RNA host gene 12	Homo sapiens	141-173
17365666-1	2007	OBJECTIVE: Acclimatization to reduced environmental oxygen includes erythropoietin-regulated increase in erythrocytes enhancing the blood"s oxygen content.	Oxygen	52-58	erythropoietin	Mus musculus	68-82
31409643-6	2019	Interestingly, ectopic SMURF2 expression not only decreased ChREBP levels, but also reduced aerobic glycolysis, increased oxygen consumption, and decreased cell proliferation in colorectal cancer cells.	Oxygen	122-128	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	23-29
31409643-7	2019	Moreover, SMURF2 knockdown increased aerobic glycolysis, decreased oxygen consumption, and enhanced cell proliferation in these cells, mostly because of increased ChREBP accumulation.	Oxygen	67-73	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	10-16
31536092-7	2019	Configuration interaction applications to single bond dissociations of water and glycine, and multiple bond dissociations of ethylene and oxygen produce dissociation energy curves in close agreement with CI calculations based on canonical SCF orbitals for the entire range of internuclear distances.	Oxygen	138-144	KIT ligand	Homo sapiens	239-242
31318148-7	2019	Ectopic expression of Klotho, an antagonist of endogenous Wnt/beta-catenin activity, abolished renal fibrosis in d-galactose (d-gal)-induced accelerated aging mouse model and significantly protected renal mitochondrial functions by preserving mass and diminishing the production of reactive oxygen species.	Oxygen	291-297	klotho	Mus musculus	22-28
17365666-1	2007	OBJECTIVE: Acclimatization to reduced environmental oxygen includes erythropoietin-regulated increase in erythrocytes enhancing the blood"s oxygen content.	Oxygen	140-146	erythropoietin	Mus musculus	68-82
17365666-3	2007	To assess this oxygen supply to the skin, the authors used erythropoietin overexpressing transgenic mice (tg6) that develop excessive erythrocytosis in an oxygen-independent manner.	Oxygen	155-161	erythropoietin	Mus musculus	59-73
16847457-4	2007	We investigated the regulation of ATF3 by oxygen deprivation.	Oxygen	42-48	activating transcription factor 3	Homo sapiens	34-38
31131995-6	2019	The role of the transcription factor Twist 1 was investigated by determining lactate production and oxygen consumption in Twist1-sufficient and Twist1-deficient murine T cells.	Oxygen	100-106	twist basic helix-loop-helix transcription factor 1	Mus musculus	37-44
31434494-7	2019	Inhibition of beta-catenin-mediated transcription using chemical inhibitors blocked SCF-induced in vitro angiogenesis in hypoxia, and injection of a beta-catenin agonist into cKit mutant mice with oxygen-induced retinopathy significantly enhanced pathological neovascularization in the retina.	Oxygen	197-203	catenin (cadherin associated protein), beta 1	Mus musculus	14-26
31556998-1	2019	Swapping of an oxygen atom of water with that of a pentavalent actinide dioxide cation, AnO2+ also called an "actinyl", requires activation of an An-O bond.	Oxygen	15-21	anoctamin 2	Homo sapiens	88-92
31434494-7	2019	Inhibition of beta-catenin-mediated transcription using chemical inhibitors blocked SCF-induced in vitro angiogenesis in hypoxia, and injection of a beta-catenin agonist into cKit mutant mice with oxygen-induced retinopathy significantly enhanced pathological neovascularization in the retina.	Oxygen	197-203	catenin (cadherin associated protein), beta 1	Mus musculus	149-161
17201389-2	2007	The rhodium-dioxygen complexes, Rh(eta2-O2), Rh(eta2-O2)2, and Rh(eta2-O2)2(eta1-OO), are produced spontaneously on annealing.	Oxygen	81-83	secreted phosphoprotein 1	Homo sapiens	76-80
31402373-7	2019	Simultaneously, CaO2 could significantly downregulate multidrug resistance-associated protein 2 (MRP2) by O2-dependent hypoxia-inducible factor 1 (HIF-1) inactivation.	Oxygen	18-20	ATP binding cassette subfamily C member 2	Homo sapiens	54-95
31402373-7	2019	Simultaneously, CaO2 could significantly downregulate multidrug resistance-associated protein 2 (MRP2) by O2-dependent hypoxia-inducible factor 1 (HIF-1) inactivation.	Oxygen	18-20	ATP binding cassette subfamily C member 2	Homo sapiens	97-101
31635145-5	2019	Sex-stratified linear regression models adjusted for age, height, smoking, body fat, lean mass, physical activity, and depression analyzed the association between BDNF and maximal oxygen consumption (VO2peak), maximal oxygen consumption normalized for body weight (VO2peak/kg), and oxygen consumption at the anaerobic threshold (VO2@AT).	Oxygen	180-186	brain derived neurotrophic factor	Homo sapiens	163-167
31737212-8	2019	Loss-of-function experiments indicated that treatment of the cells with inhibitors against miR-217 and miR-138-5p promoted cell viability and superoxide dismutase (SOD) activity, while the induction of cell apoptosis, lactate dehydrogenase (LDH) activity, and the reactive oxygen species (ROS) release were inhibited in MPP+-induced SH-SY5Y cells.	Oxygen	273-279	microRNA 217	Homo sapiens	91-98
17727264-0	2007	Oxygen delivery at sea level and altitude (after slow ascent to 5000 meters), at rest and in mild exercise.	Oxygen	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	19-22
31632076-1	2019	Purpose: Reactive oxygen species modulator 1 (ROMO1) is a novel protein regulating intracellular reactive oxygen species production.	Oxygen	18-24	reactive oxygen species modulator 1	Homo sapiens	46-51
31578243-2	2019	Here, we show that THP inhibits the generation of reactive oxygen species (ROS) both in the kidney and systemically.	Oxygen	59-65	uromodulin	Homo sapiens	19-22
31136722-7	2019	Notably, 3% O2 only significantly increased the expression of HIF-1alpha in cardiomyocytes, while 1% O2 not only increased the expression of HIF-1alpha but also increased the apoptotic rate in cardiomyocytes.	Oxygen	12-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	62-72
31136722-7	2019	Notably, 3% O2 only significantly increased the expression of HIF-1alpha in cardiomyocytes, while 1% O2 not only increased the expression of HIF-1alpha but also increased the apoptotic rate in cardiomyocytes.	Oxygen	101-103	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	141-151
17537234-11	2007	These results show that cells with stem cell characteristics were isolated from the IPFP of elderly patients with osteoarthritis and that their response to chondrogenic culture was enhanced by lowered oxygen tension, which upregulated HIF2alpha and increased the synthesis and assembly of matrix during chondrogenesis.	Oxygen	201-207	endothelial PAS domain protein 1	Homo sapiens	235-244
31066963-6	2019	In the case of alpha-d-Glcp-(1 4)-beta-d-Glcp-OMe, the existence of a transglycosidic hydrogen bond O2"   HO3 was proven by the presence of a cross-peak in 1 H,13 C HSQC-TOCSY experiments as a result of direct TOCSY transfer between HO3 of the reducing end residue and H2" (detected at C2") of the terminal residue.	Oxygen	100-102	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	106-109
31066963-6	2019	In the case of alpha-d-Glcp-(1 4)-beta-d-Glcp-OMe, the existence of a transglycosidic hydrogen bond O2"   HO3 was proven by the presence of a cross-peak in 1 H,13 C HSQC-TOCSY experiments as a result of direct TOCSY transfer between HO3 of the reducing end residue and H2" (detected at C2") of the terminal residue.	Oxygen	100-102	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	233-236
31302569-2	2019	The NOX2-centered NADPH oxidase shuttles electrons from cytoplasmic NADPH to molecular oxygen in phagosomes or the extracellular space to produce oxidants that support optimal antimicrobial activity by phagocytes.	Oxygen	87-93	cytochrome b-245 beta chain	Homo sapiens	4-8
31135464-10	2019	Hyperbaric oxygen reduced the inflammatory reaction and glial scar formation by inhibiting inflammation-related factors iNOS and COX-2 and glial scar-related components GFAP and NG2.	Oxygen	11-17	glial fibrillary acidic protein	Rattus norvegicus	169-173
17120095-1	2007	An oxygen transfer model was established for Pichia pastoris growing on glycerol and methanol in a stirred tank bioreactor and expressing a recombinant human serum albumin (rHSA).	Oxygen	3-9	CD24 molecule	Rattus norvegicus	173-177
31348907-3	2019	The aim of this study was to assess the levels of IL-17A production in the mice model of oxygen-induced retinopathy (OIR) and elucidate its potential roles.	Oxygen	89-95	interleukin 17A	Mus musculus	50-56
31632293-9	2019	This effect is mediated by reversing the expression profile of oxygen homeostasis-related genes; i.e., significant down regulation of HBBR and upregulation of HBM, HBZ, and HEPH in blood, as well as a significant upregulation of HBA1, HBBR, HBE, HBZ, and PHD2 in breast muscle compared to the positive control.	Oxygen	63-69	hephaestin	Gallus gallus	173-177
31245867-8	2019	The constant oxygen therapy only decreased the HIF-1alpha expression at day 14 and 21.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	47-57
31240921-4	2019	In contrast, the element-element BDE trend for the 2p homologues is second pi &gt; first pi &gt; sigma for nitrogen and oxygen, and sigma &gt; first pi &gt; second pi for carbon.	Oxygen	120-126	homeobox D13	Homo sapiens	33-36
30912813-6	2019	I hypothesize that AOX allowed for metabolic flexibility during the stochastic oxygen environment of early Earth which shaped the evolution of basal metazoans.	Oxygen	79-85	acyl-CoA oxidase 1	Homo sapiens	19-22
31323446-11	2019	The induction of G2/M cell-cycle arrest and apoptosis by LCB was confirmed by Annexin V/7-AAD double staining, ER stress and reactive oxygen species induction, mitochondrial membrane potential loss and caspase activation as well as related-proteins regulation.	Oxygen	134-140	clathrin light chain B	Homo sapiens	57-60
31554796-6	2019	Furthermore, reactive oxygen species (ROS) produced by the NADPH oxidase Nox in enterocytes, are required for p38 activation in enterocytes following infection or wounding, and for ISC activation upon infection or detergent exposure.	Oxygen	22-28	licorne	Drosophila melanogaster	110-113
17086571-5	2007	The second domino process, triggered by oxygen and sunlight, allowed the transformation of the initial tetracyclic adducts into the final products after B ring aromatization, silyl deprotection and C-1 oxidation.	Oxygen	40-46	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	198-201
31645842-4	2019	It has been reported that decreased levels of the mitochondrial inner membrane proteins TIMM23 and NDUFS3 are associated with the increased generation of reactive oxygen species and mitochondrial depolarization.	Oxygen	163-169	translocase of inner mitochondrial membrane 23	Homo sapiens	88-94
31632531-9	2019	The expression of GCN2 is increased in oxygen-glucose deprivation/reoxygenation (OGD/R) model cells and GCN2 interference reduces the inflammation and oxidative stress in H9C2 cells after OGD/R.	Oxygen	39-45	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	18-22
17022961-2	2007	Evidence from in vitro and structural analyses supports a critical role for Cited2 in down-regulating HIF-1-mediated transcription by competing for binding with oxygen-sensitive HIF-1alpha to transcriptional co-activators CBP/p300.	Oxygen	161-167	hypoxia inducible factor 1, alpha subunit	Mus musculus	178-188
31547228-5	2019	This mechanism, based on ER chaperones like calnexin and ER oxidoreductases like Ero1alpha, controls reactive oxygen production within the ER, which can chemically modify the proteins controlling ER-mitochondria tethering, or mitochondrial membrane dynamics.	Oxygen	110-116	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	81-90
31381323-7	2019	Spin-coated films retained up to 85% activity after several weeks of exposure to oxygen and light, while analogous films of TIPS-pentacene showed full degradation after 4 days, showcasing the excellent stability of this class of singlet fission scaffold.	Oxygen	81-87	spindlin 1	Homo sapiens	0-4
31484989-6	2019	To address this hypothesis, we combined the Mcp1 model with xenotopic expression of the alternative oxidase (AOX), which provides a sink for electrons blocked from passage to oxygen via respiratory complexes III and IV.	Oxygen	175-181	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	109-112
31131557-11	2019	We observed the overexpression since 24 hr of perfusion of the APC and PCK1 proteins upstream in the oxygen-rich area of the device.	Oxygen	101-107	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	71-75
17045587-9	2007	Thus, reduced oxygen levels lead to activation of the Dll4-Notch-Hey2 signaling cascade and subsequent repression of COUP-TFII in endothelial progenitor cells.	Oxygen	14-20	delta like canonical Notch ligand 4	Homo sapiens	54-58
31131557-12	2019	The overexpression of GS, GCK, CYP1A, and HIFalpha proteins were observed downstream in the oxygen-poor area.	Oxygen	92-98	glutamate-ammonia ligase	Rattus norvegicus	22-24
31551713-10	2019	It lowered the cellular reactive oxygen species (ROS) level in C17.2 cells via Nuclear Factor Erythroid 2-Related Factor 1/2 (NRF1/2) - NAD(P)H Quinone Dehydrogenase 1 (NQO-1) - Heme Oxygenase 1 (HO-1) pathway.	Oxygen	33-39	NAD(P)H dehydrogenase, quinone 1	Mus musculus	136-167
31598470-4	2019	One of the most important proteins in the inner membrane of mitochondria is Reactive Oxygen Species (ROS) Modulator 1 (ROMO1) that interferes with the production of ROS, and with increasing the rate of this protein, oxidative stress will increase, which ultimately leads to some diseases, especially cancer.	Oxygen	85-91	reactive oxygen species modulator 1	Homo sapiens	119-124
31551778-0	2019	PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.	Oxygen	55-61	PTEN induced kinase 1	Homo sapiens	0-5
17285444-5	2007	The expression of Kv1.2, Kv1.5, Kv2.1, and Kv3.1, putative oxygen-sensitive Kv channels that open in response to oxygen, was evaluated at both the mRNA and protein levels, using quantitative real-time polymerase chain reaction and immunohistochemistry.	Oxygen	59-65	potassium voltage-gated channel subfamily C member 1	Rattus norvegicus	43-48
30693533-1	2019	The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four-electron reduction of oxygen to water alongside the cytochrome-based electron transfer chain.	Oxygen	131-137	acyl-CoA oxidase 1	Homo sapiens	4-23
30693533-1	2019	The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four-electron reduction of oxygen to water alongside the cytochrome-based electron transfer chain.	Oxygen	131-137	acyl-CoA oxidase 1	Homo sapiens	25-28
31425603-1	2019	In Saccharomyces cerevisiae, acyl-coenzyme A desaturation by Ole1 requires molecular oxygen.	Oxygen	85-91	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	61-65
17598161-4	2007	In addition, this study tested the hypothesis that in vivo exposure to different oxygen (O(2)) concentrations causes a differential activation of G proteins in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus.	Oxygen	89-93	carbonic anhydrase 1	Rattus norvegicus	164-167
30950975-7	2019	RESULTS: Tn-C mRNA expression was markedly increased by both oxygen and glucose deprivation and Ang II (P < 0.01, respectively).	Oxygen	61-67	tenascin C	Homo sapiens	9-13
31055628-7	2019	Consistently, hypoxia-cultured PC12 cells (O2/N2/CO2, 1:94:5, 8 h) caused cellular injury (LDH release and necroposis) concomitant with up-regulation of necroptosis-associated proteins, and these phenomena were blocked in the presence of ligustroflavone (25 muM) except the elevated RIPK1 levels.	Oxygen	43-45	receptor interacting serine/threonine kinase 1	Rattus norvegicus	283-288
17018578-7	2007	We demonstrate that inhibition of HO1 reflects an interaction of MGd with NADPH-cytochrome P450 reductase, the electron donor for HO1, that results in diversion of reducing equivalents from heme oxidation to oxygen reduction.	Oxygen	208-214	heme oxygenase 1	Homo sapiens	34-37
31799945-2	2019	Under appropriate operating conditions, the B-MBR was capable of achieving excellent treated water quality in terms of biochemical oxygen demand and concentration of total nitrogen.	Oxygen	131-137	translocator protein	Homo sapiens	46-49
31146014-0	2019	Hyperbaric oxygen inhibits the HMGB1/RAGE signaling pathway by upregulating Mir-107 expression in human osteoarthritic chondrocytes.	Oxygen	11-17	advanced glycosylation end-product specific receptor	Homo sapiens	37-41
17018578-7	2007	We demonstrate that inhibition of HO1 reflects an interaction of MGd with NADPH-cytochrome P450 reductase, the electron donor for HO1, that results in diversion of reducing equivalents from heme oxidation to oxygen reduction.	Oxygen	208-214	heme oxygenase 1	Homo sapiens	130-133
31484613-4	2019	Conclusion VDR acts as a regulator for the expressions of intestinal mucosal barrier proteins under hypoxia environment in DLD-1 colon cell line,indicating that VDR pathway may be another important protective mechanism for gut barrier in low-oxygen environment.	Oxygen	242-248	vitamin D receptor	Homo sapiens	11-14
31484613-4	2019	Conclusion VDR acts as a regulator for the expressions of intestinal mucosal barrier proteins under hypoxia environment in DLD-1 colon cell line,indicating that VDR pathway may be another important protective mechanism for gut barrier in low-oxygen environment.	Oxygen	242-248	vitamin D receptor	Homo sapiens	161-164
31291092-5	2019	Once released, GOx can rapidly deplete glucose and molecular oxygen in tumor cells while the toxic side product, i.e., H2O2, can be readily decomposed by CAT for site-specific and low-toxicity tumor starvation.	Oxygen	61-67	hydroxyacid oxidase 1	Homo sapiens	15-18
31424469-5	2019	Specifically, an overpotential as low as 283 mV could drive the benchmark current density of 10 mA cm-2 for the oxygen evolution reaction, significantly lower than the overpotential required for the NiF2 (393 mV) and Ni2P materials (342 mV); the maximum current density for urea electrooxidation could reach 157.35 mA cm-2 at 1.53 V, which was much higher than those of NiF2 (23.55 mA cm-2) and Ni2P (102.72 mA cm-2).	Oxygen	112-118	zinc finger protein 335	Homo sapiens	199-203
31424469-5	2019	Specifically, an overpotential as low as 283 mV could drive the benchmark current density of 10 mA cm-2 for the oxygen evolution reaction, significantly lower than the overpotential required for the NiF2 (393 mV) and Ni2P materials (342 mV); the maximum current density for urea electrooxidation could reach 157.35 mA cm-2 at 1.53 V, which was much higher than those of NiF2 (23.55 mA cm-2) and Ni2P (102.72 mA cm-2).	Oxygen	112-118	zinc finger protein 335	Homo sapiens	370-374
31374171-1	2019	A major concern about glucose oxidase (GOx)-mediated cancer starvation therapy is its ability to induce serious oxidative damage to normal tissues through the massive production of H2O2 byproducts in the oxygen-involved glucose decomposition reaction, which may be addressed by using a H2O2 scavenger, known as an antioxidation agent.	Oxygen	204-210	hydroxyacid oxidase 1	Homo sapiens	22-37
31374171-1	2019	A major concern about glucose oxidase (GOx)-mediated cancer starvation therapy is its ability to induce serious oxidative damage to normal tissues through the massive production of H2O2 byproducts in the oxygen-involved glucose decomposition reaction, which may be addressed by using a H2O2 scavenger, known as an antioxidation agent.	Oxygen	204-210	hydroxyacid oxidase 1	Homo sapiens	39-42
31280720-6	2019	Doping produces a striking structural alteration in the Sigma5 class of grain boundaries that enhances oxygen diffusivity even further.	Oxygen	103-109	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	56-62
31438493-9	2019	The surfaces of both alloys were contaminated by oxygen where TiO2 and HfO2 formed respectively in the alloys ZF6 and ZF9.	Oxygen	49-55	zinc finger protein 587	Homo sapiens	110-113
18084894-3	2007	The NADH oxidase primarily catalyzes the reduction of oxygen by NADH to form H2O2, while the Prx immediately reduces H2O2 (or ROOH) to water (or ROH).	Oxygen	54-60	periaxin	Homo sapiens	93-96
31438493-9	2019	The surfaces of both alloys were contaminated by oxygen where TiO2 and HfO2 formed respectively in the alloys ZF6 and ZF9.	Oxygen	49-55	Kruppel like factor 6	Homo sapiens	118-121
31386694-9	2019	Overall, our data demonstrate that lack of Sirt1 caused a significantly increased generation of reactive oxygen species that resulted in chronic inflammation and regeneration.	Oxygen	105-111	sirtuin 1	Danio rerio	43-48
31227525-6	2019	Furthermore, STAT supercompetitors have elevated reactive oxygen species, an anti-oxidant response and increased ecdysone signaling.	Oxygen	58-64	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	13-17
18084894-4	2007	Consequently, the NADH oxidase-Prx system catalyzes the reduction of both oxygen and hydrogen peroxide to water with NADH as the preferred electron donor.	Oxygen	74-80	periaxin	Homo sapiens	31-34
17345743-1	2006	The aerobic oxidation of alcohols in water can be performed efficiently in the presence of a catalytic amount of the water-soluble diruthenium complex Ru2(micro-OAc)3(micro-CO3) under an atmospheric pressure (1 atm) of O2.	Oxygen	219-221	doublecortin domain containing 2	Homo sapiens	151-154
31048253-7	2019	In the INAzymes system, glucose is converted to gluconic acid by GOx in the presence of oxygen to produce H2O2 as an intermediate.	Oxygen	88-94	hydroxyacid oxidase 1	Homo sapiens	65-68
31048249-4	2019	Based on Job"s plot and in situ mass spectra, two STH molecules will complex with Al3+ to form 2:1 complexation with oxygen atoms of hydroxyl and carbonyl groups and nitrogen atom of CN bond participating in coordination.	Oxygen	117-123	saitohin	Homo sapiens	50-53
17130487-5	2006	c-Cbl(A/-) mice also display elevated oxygen consumption (13%) and are protected against high-fat diet-induced obesity and insulin resistance.	Oxygen	38-44	Casitas B-lineage lymphoma	Mus musculus	0-5
31382955-12	2019	The signal intensity of SP-B analog in each surfactant-treated animal, which represents the surfactant distributed to the peripheral right lung, correlated well with the physiologic response as assessed by the area under the curves of the individual arterial partial oxygen pressure and dynamic lung compliance curves of the lambs.	Oxygen	267-273	pulmonary surfactant-associated protein B	Ovis aries	24-28
16998073-10	2006	We also show that Ace2 is required for filamentation in response to low oxygen concentrations (hypoxia).	Oxygen	72-78	DNA-binding transcription factor ACE2	Saccharomyces cerevisiae S288C	18-22
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Oxygen	136-142	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	81-85
31030174-3	2019	Among those glucose sensors, few have been thought and well-engineered and do not solve the problems associated with glucose oxidase; among which the O2 sensitivity of the enzyme or the competition between O2 and redox mediators for GOx"s electrons.	Oxygen	150-152	hydroxyacid oxidase 1	Homo sapiens	233-236
31030174-3	2019	Among those glucose sensors, few have been thought and well-engineered and do not solve the problems associated with glucose oxidase; among which the O2 sensitivity of the enzyme or the competition between O2 and redox mediators for GOx"s electrons.	Oxygen	206-208	hydroxyacid oxidase 1	Homo sapiens	233-236
31030174-4	2019	Enzyme engineering has been employed to solve those issues but screening GOx in homogeneous solution with O2 as an electron acceptor is not suitable.	Oxygen	106-108	hydroxyacid oxidase 1	Homo sapiens	73-76
17059463-8	2006	Under steady-state conditions, the ANT moderately controlled oxygen uptake (control coefficient C = 0.13) and phosphorylation (C = 0.14) flux.	Oxygen	61-67	solute carrier family 25 member 6	Homo sapiens	35-38
31303425-5	2019	A Wald chi-square test was used to compare the coefficients estimating the relationship of peak oxygen consumption (VO2peak) at CPX1 with VO2peak measured at CPX2 with time until death for all-cause mortality.	Oxygen	96-102	complexin 1	Homo sapiens	128-132
31303425-5	2019	A Wald chi-square test was used to compare the coefficients estimating the relationship of peak oxygen consumption (VO2peak) at CPX1 with VO2peak measured at CPX2 with time until death for all-cause mortality.	Oxygen	96-102	complexin 2	Homo sapiens	158-162
31632627-7	2019	In addition, activity of the pathogenesis-related proteins glucanase (PR2) and chitinase (PR3), lipoxygenase and polyphenol oxidase was enhanced together with an increased capacity to remove reactive oxygen species (ROS).	Oxygen	99-105	basic chitinase	Arabidopsis thaliana	90-93
30986639-4	2019	In the absence of UV, decreasing pH promoted the release of Hg2+ from NaClO2-NH4OH; introducing NO, SO2, O2, Br-, Cl-, and HCO3- suppressed Hg0 oxidation.	Oxygen	74-76	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	60-63
31179684-6	2019	While obscure even an overlapped interface was observed over Pt/CeZrO2, resulting in the formation of PtO because of the oxygen migration from CeZrO2 to Pt species (confirmed by CO-FTIR, the cycled H2-TPR and transmission electron microscopy results).	Oxygen	121-127	translocated promoter region, nuclear basket protein	Homo sapiens	201-204
31278195-4	2019	Mice lacking a receptor on their erythrocytes called ADORA2B, which increases O2 delivery, and patients with CKD were studied to assess the role of ADORA2B-mediated O2 delivery in CKD.	Oxygen	78-80	adenosine A2b receptor	Mus musculus	53-60
31278195-6	2019	Genetic studies in mice revealed that erythrocyte ADORA2B signaling leads to AMPK-stimulated activation of BPG mutase, promoting 2,3-BPG production and O2 delivery to counteract kidney hypoxia, tissue damage, and disease progression in Ang II-induced CKD.	Oxygen	152-154	adenosine A2b receptor	Mus musculus	50-57
31460390-0	2019	Molecular and Dissociative Adsorption of Oxygen on Au-Pd Bimetallic Clusters: Role of Composition and Spin State of the Cluster.	Oxygen	41-47	spindlin 1	Homo sapiens	102-106
31460390-5	2019	Here, we present a systematic theoretical investigation of reaction pathways for O2 adsorption and dissociation on Au8, Pd8, and Au8-n Pd n (n = 1-7) nanoclusters in different spin states.	Oxygen	81-83	spindlin 1	Homo sapiens	176-180
31460390-6	2019	The density functional calculations point out that the O2 dissociation barriers can be significantly reduced with the help of certain bimetallic clusters along specific spin channels.	Oxygen	55-57	spindlin 1	Homo sapiens	169-173
31460390-8	2019	The enhanced O2 binding subsequently leads to low activation barriers of 0.98 and 1.19 eV along the doublet and quartet spin channels, respectively, without the involvement of any spin flip-over for O2 dissociation.	Oxygen	13-15	spindlin 1	Homo sapiens	120-124
31276397-8	2019	Because Sr2+/Ca2+ substitution alters this D-O-D bending mode but the D1-S169A mutation does not, we conclude that the water-derived oxygen that relocates and becomes O6/Ox derives from the Ca2+-bound W3.	Oxygen	133-139	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	167-172
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	36-38	nuclear factor of activated T cells 5	Mus musculus	126-131
31067085-6	2019	MEF cells were exposed to 21% or 1% O2 in a time course curve of 48 h. We found that, in MEF-NFAT5+/+ cells exposed to 1% O2, NFAT5 was upregulated and translocated into the nuclei, and its transactivation domain activity was induced, concomitant with iNOS, aquaporin 1 (AQP-1), and urea transporter 1 (UTA-1) upregulation.	Oxygen	122-124	nuclear factor of activated T cells 5	Mus musculus	126-131
17030577-4	2006	The napA strain was more sensitive to oxidative stress reagents and to oxygen, and it contained fourfold more intracellular free iron and more damaged DNA than the parent strain.	Oxygen	71-77	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	4-8
30395227-8	2019	In HEK293 cells transfected with oxygen-stable HIF-1alpha and PRKCBP1, we demonstrated inhibition of HIF-1 activity by a luciferase reporter assay.	Oxygen	33-39	zinc finger MYND-type containing 8	Homo sapiens	62-69
31329164-3	2019	We demonstrated that siRNA ABCA1 knockdown in podocytes led to reduced oxygen consumption capabilities associated with alterations in the oxidative phosphorylation (OXPHOS) complexes and with cardiolipin accumulation.	Oxygen	71-77	ATP binding cassette subfamily A member 1	Homo sapiens	27-32
30679163-0	2019	LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation.	Oxygen	53-59	LIM zinc finger domain containing 1	Homo sapiens	0-5
17112254-1	2006	The mechanism of the direct insertion of molecular oxygen into a palladium hydride bond has been elucidated using quantum mechanics (B3LYP/LACVP** with the PBF continuum solvent model).	Oxygen	51-57	zinc finger protein 395	Homo sapiens	156-159
30679163-3	2019	We determined the mechanistic role of LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) in cancer cell survival under oxygen-glucose deprivation conditions.	Oxygen	140-146	LIM zinc finger domain containing 1	Homo sapiens	38-101
30679163-3	2019	We determined the mechanistic role of LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) in cancer cell survival under oxygen-glucose deprivation conditions.	Oxygen	140-146	LIM zinc finger domain containing 1	Homo sapiens	103-108
30679163-9	2019	Increased LIMS1 expression was pivotal for tumor cells to survive in the oxygen-glucose deprivation conditions.	Oxygen	73-79	LIM zinc finger domain containing 1	Homo sapiens	10-15
30679163-11	2019	Furthermore, LIMS1 promoted HIF1A protein translation by activating AKT/mTOR signaling, while hypoxia-inducible factor 1 (HIF1) transactivated LIMS1 transcription, thus forming a positive feedback loop in PDAC cell adaptation to oxygen deprivation stress.	Oxygen	229-235	LIM zinc finger domain containing 1	Homo sapiens	13-18
30679163-13	2019	CONCLUSIONS: LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by activating AKT/mTOR signaling and enhancing HIF1A protein translation.	Oxygen	66-72	LIM zinc finger domain containing 1	Homo sapiens	13-18
30679163-14	2019	LIMS1 is crucial for tumor adaptation to oxygen-glucose deprivation conditions and is a promising therapeutic target for cancer treatment.	Oxygen	41-47	LIM zinc finger domain containing 1	Homo sapiens	0-5
31316050-0	2019	The inhibition of chloride intracellular channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells.	Oxygen	78-84	chloride intracellular channel 1	Homo sapiens	18-50
31316111-0	2019	Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production.	Oxygen	143-149	nucleoporin 62	Homo sapiens	25-28
16804693-1	2006	Superoxide dismutase (SODs) are metalloenzymes that catalyze the dismutation of the superoxide anion to molecular oxygen and hydrogen peroxide and, thus, form a crucial part of the cellular antioxidant defense mechanism.	Oxygen	114-120	superoxide dismutase [Cu-Zn]	Bombyx mori	22-26
31108095-0	2019	Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.	Oxygen	11-17	brain-derived neurotrophic factor	Rattus norvegicus	88-92
31108095-14	2019	These findings suggest that hyperbaric oxygen therapy ameliorates spinal cord injury-induced neurological impairment by anti-apoptosis and suppressing dendritic/synaptic degeneration via upregulating the BDNF/TrkB signaling pathways.	Oxygen	39-45	brain-derived neurotrophic factor	Rattus norvegicus	204-208
17097563-2	2006	In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed genes like VEGF.	Oxygen	50-52	endothelial PAS domain protein 1	Mus musculus	10-20
31215559-4	2019	The oxygen deficient MnTiO3 towards O2 - exhibits a sensitivity of 126.48 muA muM-1 cm-2 and a detection limit of 1.54 nM, among the best performance of O2 - sensing platforms.	Oxygen	4-10	PWWP domain containing 3A, DNA repair factor	Homo sapiens	78-83
31215559-4	2019	The oxygen deficient MnTiO3 towards O2 - exhibits a sensitivity of 126.48 muA muM-1 cm-2 and a detection limit of 1.54 nM, among the best performance of O2 - sensing platforms.	Oxygen	36-38	PWWP domain containing 3A, DNA repair factor	Homo sapiens	78-83
31215559-4	2019	The oxygen deficient MnTiO3 towards O2 - exhibits a sensitivity of 126.48 muA muM-1 cm-2 and a detection limit of 1.54 nM, among the best performance of O2 - sensing platforms.	Oxygen	153-155	PWWP domain containing 3A, DNA repair factor	Homo sapiens	78-83
30786776-5	2019	Sequential delivery by transduced BM cells of VEGFA and S1P led to increased endothelial cell numbers and shorter extravascular distances in the infarct zone, which support better oxygen diffusion 28 days post myocardial infarction, as shown by automated 3D image analysis of the microvasculature.	Oxygen	180-186	vascular endothelial growth factor A	Mus musculus	46-51
30786776-8	2019	The results indicate that BM cells engineered to deliver VEGFA/S1P angiogenic factors sequentially may constitute a promising strategy to improve micro-vascularization and oxygen diffusion, thus limiting the adverse consequences of cardiac ischemia.	Oxygen	172-178	vascular endothelial growth factor A	Mus musculus	57-62
31142573-3	2019	Studies have demonstrated that kidney formation is highly dependent on oxygen concentration, which is largely regulated by von Hippel-Lindau (VHL; a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription factors activated by hypoxia).	Oxygen	71-77	von Hippel-Lindau tumor suppressor	Mus musculus	123-140
31078766-6	2019	After that, the GOx in GMP@RBC could effectively catalyze the conversion of endogenous glucose to hydrogen peroxide (H2O2) in the presence of oxygen.	Oxygen	142-148	hydroxyacid oxidase 1	Homo sapiens	16-19
17097563-2	2006	In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed genes like VEGF.	Oxygen	79-85	endothelial PAS domain protein 1	Mus musculus	10-20
30387149-11	2019	These data suggest that GNA14 distinctively mediates fetoplacental endothelial cell migration and permeability in response to FGF2 and VEGFA, possibly in part by altering activation of PLCbeta3 under physiological chronic low oxygen.	Oxygen	226-232	G protein subunit alpha 14	Homo sapiens	24-29
17097563-2	2006	In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed genes like VEGF.	Oxygen	154-160	endothelial PAS domain protein 1	Mus musculus	10-20
17111303-8	2006	In all the groups, the maximal oxygen consumption/kg correlated positively with basal levels of testosterone (r=0.60, p&lt;0.001) and insulin (r=0.34), and negatively to ghrelin (r=-0.35) and leptin (r=-0.32) (p&lt;0.05).	Oxygen	31-37	leptin	Homo sapiens	192-198
30936488-7	2019	By contrast, Heimdallarchaeum LC2 and LC3 genomes encode enzymes potentially enabling the oxidation of organic substrates using nitrate or oxygen as electron acceptors.	Oxygen	139-145	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	38-41
31026104-3	2019	Subsequently, these molecules were deposited onto Cu(111) and scanning-tunneling-microscopy(STM)-based atom manipulation was employed to dissociate the oxygen atoms.	Oxygen	152-158	sulfotransferase family 1A member 3	Homo sapiens	92-95
16777999-1	2006	We previously showed that after seven generations of artificial selection of rats for running capacity, maximal O2 uptake (VO2max) was 12% greater in high-capacity (HCR) than in low-capacity runners (LCR).	Oxygen	112-114	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	165-168
31182001-2	2019	The Ngb (neuroglobin) is a hemoprotein predominantly expressed in the brain with a high affinity for oxygen.	Oxygen	101-107	neuroglobin	Homo sapiens	4-7
31182001-2	2019	The Ngb (neuroglobin) is a hemoprotein predominantly expressed in the brain with a high affinity for oxygen.	Oxygen	101-107	neuroglobin	Homo sapiens	9-20
31182001-6	2019	Results- Serum Ngb level was correlated positively with cerebral microdialysis parameters and brain tissue oxygen tension ( P&lt;0.001).	Oxygen	107-113	neuroglobin	Homo sapiens	15-18
31182001-9	2019	Conclusions- Ngb may be a potential biomarker for reflecting brain tissue oxygen tension, brain metabolism, and functional outcome in severe aSAH patients and merits further study in the context of aSAH.	Oxygen	74-80	neuroglobin	Homo sapiens	13-16
31174623-11	2019	The expression of NANOG, OCT4A, OCT4B and SOX2 was increased at 3% O2.	Oxygen	67-69	Nanog homeobox	Homo sapiens	18-23
31174623-11	2019	The expression of NANOG, OCT4A, OCT4B and SOX2 was increased at 3% O2.	Oxygen	67-69	SRY-box transcription factor 2	Homo sapiens	42-46
31142197-4	2019	The primary outcome was to describe the relationship between Met-Hb and other indices of tissue oxygenation (venous saturation, estimated arteriovenous oxygen difference [Est AV-Diff], and lactate).	Oxygen	96-102	hemoglobin subunit gamma 2	Homo sapiens	61-67
31142197-8	2019	Venous Met-Hb demonstrated a significant inverse relationship with venous oxygen saturation (R = -0.6; P &lt; .001) and Hb (R = -0.3, P &lt; .001) and a direct relationship with the Est AV-Diff (R = 0.3, P &lt; .001).	Oxygen	74-80	hemoglobin subunit gamma 2	Homo sapiens	7-13
16777999-2	2006	This difference was due exclusively to a greater O2 uptake and utilization by skeletal muscle of HCR, without differences between lines in convective O2 delivery to muscle by the cardiopulmonary system (QO2max).	Oxygen	49-51	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	97-100
16860563-5	2006	Furthermore, production of reactive oxygen species and cell death induced by 6-OHDA in SH-SY5Y cells and mesencephalic neurons were inhibited by addition of the recombinant DJ-1.	Oxygen	36-42	Parkinsonism associated deglycase	Homo sapiens	173-177
31213272-2	2019	In 10 urothelial cancers, the oxygen sensitive subunit HIF-1alpha, which is upregulated by hypoxia, was overexpressed.	Oxygen	30-36	hypoxia inducible factor 1 subunit alpha	Bos taurus	55-65
30882866-6	2019	An in planta complementation assay indicated that CaMV35S::STOP2 or CaMV35S::HsfA2 partially rescued the low-oxygen tolerance of the stop1 mutant, which was concomitant with recovered expression of genes regulating low-pH tolerance and genes encoding molecular chaperones.	Oxygen	109-115	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	59-64
31253794-3	2019	Using reverse genetics and comparative genomics, we identify two factors responsible for 5-hydroxyuridine (ho5U) formation, which is the first step of the cmo5U synthesis: TrhP (formerly known as YegQ), a peptidase U32 family protein, is involved in prephenate-dependent ho5U formation; and TrhO (formerly known as YceA), a rhodanese family protein, catalyzes oxygen-dependent ho5U formation and bypasses cmo5U biogenesis in a subset of tRNAs under aerobic conditions.	Oxygen	360-366	hypothetical protein	Escherichia coli	315-319
16969476-5	2006	We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth.	Oxygen	110-116	transketolase like 1	Homo sapiens	16-21
31139793-6	2019	However, most of these transfers are rattling events between the participating oxygens, one of which is the newly formed H3O+ ion adjacent to the interface.	Oxygen	79-86	H3 clustered histone 15	Homo sapiens	121-124
30981984-3	2019	This study investigated the specific role of microRNA-145 (miR-145) in regulating vascular endothelial cell (EC) function and pathological ocular angiogenesis in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	179-185	microRNA 145a	Mus musculus	59-66
31163581-6	2019	mRNA expression levels of HO-1 remained unchanged in both the groups; however, inflammatory mediator levels were significantly lower in the CO/O2 group than in the air group.	Oxygen	143-145	heme oxygenase 1	Canis lupus familiaris	26-30
30924607-10	2019	RESULTS: The plasma concentration-time profiles of total rFVIII and VWF, and the luminescent oxygen channeling immunoassay signal-time profiles of the rFVIII:VWF complex were adequately described using a two-compartment quasi-steady-state target-mediated drug disposition model (Kss  = 0.14 nmol L-1 ).	Oxygen	93-99	von Willebrand factor	Rattus norvegicus	158-161
16953568-0	2006	Photoreaction cycle of the light, oxygen, and voltage domain in FKF1 determined by low-temperature absorption spectroscopy.	Oxygen	34-40	flavin-binding, kelch repeat, f box 1	Arabidopsis thaliana	64-68
30092712-7	2019	Upregulation of PDK1 in ectopic endometriotic stromal cells was accompanied by increases in lactate production and oxygen consumption rate when compared to eutopic endometrial stromal cells.	Oxygen	115-121	pyruvate dehydrogenase kinase 1	Homo sapiens	16-20
30092712-8	2019	Furthermore, our data showed that inhibition of PDK1 activity by treatment with dichloroacetate inhibits the lactate production and oxygen consumption rate of ectopic stromal cells.	Oxygen	132-138	pyruvate dehydrogenase kinase 1	Homo sapiens	48-52
31108461-13	2019	Our data highlight a hitherto unrecognized role of macrophage-hepatocyte crosstalk for a joint and oxygen-dependent hepcidin production through STAT3 and CEBPdelta.	Oxygen	99-105	CCAAT enhancer binding protein delta	Homo sapiens	154-163
16953568-2	2006	FKF1 has a light, oxygen, and voltage (LOV) sensing domain binding a flavin mononucleotide (FMN) as a chromophore noncovalently.	Oxygen	18-24	flavin-binding, kelch repeat, f box 1	Arabidopsis thaliana	0-4
31110040-3	2019	A variety of devices are currently available for the delivery of CPAP, including oxygen-conserving valved systems, continuous-flow generators, portable demand-flow devices, and mechanical ventilators.	Oxygen	81-87	centromere protein J	Homo sapiens	65-69
16740642-2	2006	Oxygen-dependent hydroxylation of HIF-1alpha provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression.	Oxygen	0-6	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-44
30920104-10	2019	Our findings provide new insights into the dual mechanism of action of IAP inhibitors that depends on oxygen level and are relevant to their therapeutic application in tumors.	Oxygen	102-108	CD47 molecule	Homo sapiens	71-74
16968978-5	2006	The values of oxygen transfer capacity (OC) and efficiency (E) ranged from 18 to 170 grO2/m3.	Oxygen	14-20	C-X-C motif chemokine ligand 2	Homo sapiens	85-89
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Oxygen	47-49	DNA methyltransferase 1	Homo sapiens	96-101
30719925-8	2019	There was also a significant difference between the 0th hour and 4th hour netrin-1 (888.9 pg/mL (700.3-1175.5)) levels in the patient group ( p &lt; 0.001).There was no significant statistical difference between patients with and without neurological involvement ( p = 0.62) and between those who underwent hyperbaric oxygen therapy (HBOT) and those who did not ( p = 0.76) with respect to 4th hour netrin-1 levels.	Oxygen	318-324	netrin 1	Homo sapiens	74-82
16883555-0	2006	Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.	Oxygen	81-87	presenilin 1	Mus musculus	21-40
30503171-5	2019	Meanwhile, the PCR analysis revealed an up-regulation of genes, encoded molecules of cell-cell (ICAM1, HCAM/CD44) and cell-matrix adhesion (ITGs), extracellular matrix production (COLs) and remodeling (MMPs, HAS1) in growth-arrested ASCs at physiological hypoxia in comparison with ambient O2 (20%).	Oxygen	290-292	intercellular adhesion molecule 1	Homo sapiens	96-101
16967996-5	2006	Measurements in a different atmosphere demonstrate that the absorption of ambient gas (mainly oxygen) can significantly change the photosensitivity of CdS nanoribbons through trapping electrons from the nanoribbons.	Oxygen	94-100	CDP-diacylglycerol synthase 1	Homo sapiens	151-154
30503171-5	2019	Meanwhile, the PCR analysis revealed an up-regulation of genes, encoded molecules of cell-cell (ICAM1, HCAM/CD44) and cell-matrix adhesion (ITGs), extracellular matrix production (COLs) and remodeling (MMPs, HAS1) in growth-arrested ASCs at physiological hypoxia in comparison with ambient O2 (20%).	Oxygen	290-292	CD44 molecule (Indian blood group)	Homo sapiens	108-112
30659265-0	2019	Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells.	Oxygen	0-6	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Homo sapiens	27-32
16790428-7	2006	Using an engineered oxygen-sensitive reporter gene in a cellular background lacking endogenous HIF-1alpha and hence inducible PHD expression, we could show that increased exogenous PHD levels can compensate for a wide range of hypoxic conditions.	Oxygen	20-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	95-105
30659265-0	2019	Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells.	Oxygen	0-6	Rac family small GTPase 1	Homo sapiens	61-65
16760477-0	2006	Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.	Oxygen	127-133	endothelial PAS domain protein 1	Homo sapiens	70-80
29848205-4	2019	Accordingly, when mimicking early placental events in vitro, protein and mRNA expression of FOXM1 increased from 21% to 8% O2, reaching its highest expression at 3% oxygen tension, which reflects early implantation environment, and dropping to very low levels at 1% O2.	Oxygen	123-125	forkhead box M1	Homo sapiens	92-97
29848205-4	2019	Accordingly, when mimicking early placental events in vitro, protein and mRNA expression of FOXM1 increased from 21% to 8% O2, reaching its highest expression at 3% oxygen tension, which reflects early implantation environment, and dropping to very low levels at 1% O2.	Oxygen	165-171	forkhead box M1	Homo sapiens	92-97
29848205-4	2019	Accordingly, when mimicking early placental events in vitro, protein and mRNA expression of FOXM1 increased from 21% to 8% O2, reaching its highest expression at 3% oxygen tension, which reflects early implantation environment, and dropping to very low levels at 1% O2.	Oxygen	266-268	forkhead box M1	Homo sapiens	92-97
16760477-1	2006	The hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of target genes associated with numerous processes, including vascularization and glycolysis.	Oxygen	151-157	endothelial PAS domain protein 1	Homo sapiens	46-56
29848205-6	2019	Moreover, angiogenesis was compromised when conditioned media (CM) from FOXM1-siRNA -JEG-3 (3% O2) was added to human umbilical vein endothelial cells (HUVEC) cells; however, when CM of JEG-3 cells overexpressing FOXM1 at 1% O2 was added, the ability of HUVEC to form tubule networks was restored.	Oxygen	95-97	forkhead box M1	Homo sapiens	72-77
29848205-6	2019	Moreover, angiogenesis was compromised when conditioned media (CM) from FOXM1-siRNA -JEG-3 (3% O2) was added to human umbilical vein endothelial cells (HUVEC) cells; however, when CM of JEG-3 cells overexpressing FOXM1 at 1% O2 was added, the ability of HUVEC to form tubule networks was restored.	Oxygen	225-227	forkhead box M1	Homo sapiens	72-77
29848205-7	2019	Additionally, quantitative real-time polymerase chain reaction (PCR) assays of FOXM1 knockdown and overexpression experiments in JEG-3 cells revealed that the depletion of FOXM1 at 3% O2 and overexpression of FOXM1 at 1% O2 led to downregulation and upregulation of vascular endothelial growth factor transcriptional (VEGF) levels, respectively.	Oxygen	184-186	forkhead box M1	Homo sapiens	172-177
29848205-7	2019	Additionally, quantitative real-time polymerase chain reaction (PCR) assays of FOXM1 knockdown and overexpression experiments in JEG-3 cells revealed that the depletion of FOXM1 at 3% O2 and overexpression of FOXM1 at 1% O2 led to downregulation and upregulation of vascular endothelial growth factor transcriptional (VEGF) levels, respectively.	Oxygen	184-186	forkhead box M1	Homo sapiens	172-177
29848205-7	2019	Additionally, quantitative real-time polymerase chain reaction (PCR) assays of FOXM1 knockdown and overexpression experiments in JEG-3 cells revealed that the depletion of FOXM1 at 3% O2 and overexpression of FOXM1 at 1% O2 led to downregulation and upregulation of vascular endothelial growth factor transcriptional (VEGF) levels, respectively.	Oxygen	221-223	forkhead box M1	Homo sapiens	172-177
29848205-7	2019	Additionally, quantitative real-time polymerase chain reaction (PCR) assays of FOXM1 knockdown and overexpression experiments in JEG-3 cells revealed that the depletion of FOXM1 at 3% O2 and overexpression of FOXM1 at 1% O2 led to downregulation and upregulation of vascular endothelial growth factor transcriptional (VEGF) levels, respectively.	Oxygen	221-223	forkhead box M1	Homo sapiens	172-177
29848205-9	2019	Therefore, we demonstrate that FOXM1 may be a new regulatory protein of early placentation processes and that under chronic hypoxic conditions (1% O2) and in patients with severe PE, its levels decrease.	Oxygen	147-149	forkhead box M1	Homo sapiens	31-36
31043649-3	2019	Since Hp:Hb complexes show heme-based reactivity, kinetics of O2 dissociation from the ferrous oxygenated human Hp1-1:Hb and Hp2-2:Hb complexes (Hp1-1:Hb(II)-O2 and Hp2-2:Hb(II)-O2, respectively) have been determined.	Oxygen	62-64	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	125-130
31043649-4	2019	O2 dissociation from Hp1-1:Hb(II)-O2 and Hp2-2:Hb(III)-O2 follows a biphasic process.	Oxygen	0-2	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	41-46
16824930-0	2006	Ozone/oxygen mixture modifies the subcellular redistribution of Bax protein in renal tissue from rats treated with cisplatin.	Oxygen	6-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	64-67
31068761-5	2019	Methods: SIRT1 protein and mRNA levels were detected by Western blotting and real-time PCR in CRC cells exposed to hypoxia (1% O2).	Oxygen	127-129	sirtuin 1	Homo sapiens	9-14
16824930-4	2006	METHODS: This study was undertaken to examine the effect of the ir applications of ozone/oxygen mixture in the renal expression pattern of Bax proteins in rats treated with cisplatin.	Oxygen	89-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	139-142
16824930-13	2006	CONCLUSIONS: Expression of Bax in renal tissue seems to play an important role in the protection and recovery in cisplatin-nephrotoxicity achieved by ozone/oxygen mixture.	Oxygen	156-162	BCL2 associated X, apoptosis regulator	Rattus norvegicus	27-30
31040780-5	2019	We also found that hypoxia (2% O2) activated p38/mitogen-activated protein kinase (MAPK) signaling, and we identified p38/MAPK as an upstream regulator of MAP4 phosphorylation in endothelial cells.	Oxygen	31-33	microtubule associated protein 4	Homo sapiens	155-159
16714370-3	2006	This oxygen is thought to be either an iron-hydroperoxy species (Cpd 0) or a second spin-state of Cpd 1.	Oxygen	5-11	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	98-103
30708047-6	2019	We used an in vitro model of ischemic injury via oxygen and glucose deprivation (OGD) of cultured neurons, which led to PKA inactivation and decreased CREB phosphorylation, reduced cell viability, and increased neuronal apoptosis.	Oxygen	49-55	cAMP responsive element binding protein 1	Homo sapiens	151-155
30959909-7	2019	We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1).	Oxygen	29-35	aggrecan	Homo sapiens	96-100
30959909-7	2019	We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1).	Oxygen	29-35	collagen type I alpha 1 chain	Homo sapiens	157-163
16714370-9	2006	The nature of the iron-oxygen species is less certain but is more likely to be iron-oxo Cpd 1, given the energetics of these reactions.	Oxygen	23-29	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	88-93
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	131-137	vascular endothelial growth factor A	Rattus norvegicus	190-194
16771373-7	2006	The cation was paired with oxygen rich anions ClO4-, NO3-, or N(NO2)2- and those structures were optimized using both DFT and MP2.	Oxygen	27-33	tryptase pseudogene 1	Homo sapiens	126-129
30899930-8	2019	Therefore, the VHT can meet the two primary conditions of a photocatalyst for water splitting to generate H2 in SnX and O2 in SnX2.	Oxygen	120-122	sorting nexin 2	Homo sapiens	126-130
30803063-3	2019	The as-prepared single atoms, supported by N-doped carbon flake arrays grown on carbon nanofibers assembly (M SA@NCF/CNF), demonstrate the dual characteristics of excellent catalytic activity (reversible oxygen overpotential of 0.75 V) and high stability, owing to the greatly improved active sites" accessibility and optimized single-sites/pore-structures correlations.	Oxygen	204-210	NPHS1 adhesion molecule, nephrin	Homo sapiens	117-120
31281810-4	2019	We propose that the luminescence of C-CNC originates from the through-space conjugation of oxygen atoms and carboxyl groups of C-CNC.	Oxygen	91-97	cyclin C	Homo sapiens	36-41
31281810-4	2019	We propose that the luminescence of C-CNC originates from the through-space conjugation of oxygen atoms and carboxyl groups of C-CNC.	Oxygen	91-97	cyclin C	Homo sapiens	127-132
31281810-8	2019	As prepared C-CNC/EDA confirmed that the clusteroluminescence was attributed to the amide moieties and through-space conjugation between oxygen and carbonyl moieties.	Oxygen	137-143	cyclin C	Homo sapiens	12-17
16421206-1	2006	Myoglobin (Mb) has a purported role in facilitating O2 diffusion in tissue, especially as cellular PO2 drops or the respiration demand increases.	Oxygen	52-54	myoglobin	Homo sapiens	0-9
31275928-7	2019	Furthermore, the CoFe-CNTF also demonstrates high catalytic activity toward oxygen evolution reaction (OER) with a Tafel slope of 87.7 mV dec-1.	Oxygen	76-82	ciliary neurotrophic factor	Homo sapiens	22-26
31189877-4	2019	Oxygen-doped LaH3 (LaH3-2xOx) has an optimum ionic conductivity of 2.6 x 10-2 S cm-1, which to the best of our knowledge is the highest H- conductivity reported to date at intermediate temperatures.	Oxygen	0-6	lysophosphatidic acid receptor 6	Homo sapiens	13-17
31189877-4	2019	Oxygen-doped LaH3 (LaH3-2xOx) has an optimum ionic conductivity of 2.6 x 10-2 S cm-1, which to the best of our knowledge is the highest H- conductivity reported to date at intermediate temperatures.	Oxygen	0-6	lysophosphatidic acid receptor 6	Homo sapiens	19-28
31244673-2	2019	XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated.	Oxygen	122-128	actinin alpha 3	Homo sapiens	100-105
30683653-3	2019	Here, we show that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma stem cells (GSC) increases mitochondrial respiratory capacity and reduces production of reactive oxygen species.	Oxygen	247-253	TNF receptor associated protein 1	Homo sapiens	77-82
30855350-0	2019	Hyperbaric oxygen improves functional recovery of rats after spinal cord injury via activating stromal cell-derived factor-1/CXC chemokine receptor 4 axis and promoting brain-derived neurothrophic factor expression.	Oxygen	11-17	brain-derived neurotrophic factor	Rattus norvegicus	169-203
30855350-2	2019	This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).	Oxygen	91-97	C-X-C motif chemokine receptor 4	Rattus norvegicus	233-238
30855350-2	2019	This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).	Oxygen	91-97	brain-derived neurotrophic factor	Rattus norvegicus	263-296
30855350-2	2019	This study aimed to elucidate the mechanism underlying the protective effect of hyperbaric oxygen (HBO) against SCI-induced neurologic defects in rats via exploring the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis and expression of brain-derived neurotrophic factor (BDNF).	Oxygen	91-97	brain-derived neurotrophic factor	Rattus norvegicus	298-302
30824597-0	2019	Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation.	Oxygen	99-101	sulfatase modifying factor 1	Homo sapiens	0-31
30954471-9	2019	Ex vivo cultured slices also were sensitive to hypoxia because carbonic anhydrase IX and zinc finger E-box binding homeobox 1 (Zeb1) protein levels increased in 1% oxygen.	Oxygen	164-170	zinc finger E-box binding homeobox 1	Homo sapiens	89-125
16421206-1	2006	Myoglobin (Mb) has a purported role in facilitating O2 diffusion in tissue, especially as cellular PO2 drops or the respiration demand increases.	Oxygen	52-54	myoglobin	Homo sapiens	11-13
30954471-9	2019	Ex vivo cultured slices also were sensitive to hypoxia because carbonic anhydrase IX and zinc finger E-box binding homeobox 1 (Zeb1) protein levels increased in 1% oxygen.	Oxygen	164-170	zinc finger E-box binding homeobox 1	Homo sapiens	127-131
30787050-4	2019	Similarly, culturing the mouse beta-cell line MIN6 and islet tissue in 10% O2 also significantly increased the conversion of proinsulin into mature insulin, which was secreted in a regulated manner.	Oxygen	75-77	insulin II	Mus musculus	125-135
16740701-2	2006	Two transcription factors [hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha] are dramatically induced in hypoxic areas and regulate the expression of genes necessary for tumor adaptation to the conditions of low oxygen; however, the relative contribution of these factors is controversial.	Oxygen	223-229	endothelial PAS domain protein 1	Homo sapiens	76-86
31126512-6	2019	The salivary alpha-amylase levels were positively correlated with the AHI (r = 0.538; P &lt; 0.01) and microarousal index (r = 0.541, P &lt; 0.01), and negatively correlated with the lowest pulse oxygen saturation (r = -0.375, P &lt; 0.01).	Oxygen	196-202	amylase alpha 1A	Homo sapiens	4-26
16723075-0	2006	Effect of hyperbaric oxygen on cytochrome C, Bcl-2 and Bax expression after experimental traumatic brain injury in rats.	Oxygen	21-27	BCL2 associated X, apoptosis regulator	Rattus norvegicus	55-58
31010852-8	2019	Deletion of CD82 modulates Dectin-1 signaling, resulting in a reduction of Src and Syk phosphorylation and reactive oxygen species production.	Oxygen	116-122	CD82 molecule	Homo sapiens	12-16
30825821-3	2019	The results indicated that chemical oxygen demand (COD) was increased by SAR2 treatment and COD removal efficiency for SBBR, SAR1 and STR was 39.7%, 15.7% and 30.9% respectively.	Oxygen	36-42	CD82 molecule	Homo sapiens	73-77
31119470-6	2019	And PCC/SPCE, best operated at -0.4 V (vs. Ag/AgCl), exhibited a superior performance for O2 - detection with a sensitivity of 1.14 x 103 nA muM-1 cm-2 and a low detection limit of 140 nM (at S/N = 3).	Oxygen	90-92	PWWP domain containing 3A, DNA repair factor	Homo sapiens	141-146
30948157-0	2019	Piezo1 mediates neuron oxygen-glucose deprivation/reoxygenation injury via Ca2+/calpain signaling.	Oxygen	23-29	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	0-6
30948157-1	2019	OBJECTIVE: We investigated whether Piezo1 could regulate oxygen-glucose deprivation/reoxygenation injury of neurons through Ca2+/calpain signaling.	Oxygen	57-63	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	35-41
30948157-8	2019	CONCLUSION: Piezo1 could regulate neuron oxygen-glucose deprivation/reoxygenation injury via activation of Ca2+/calpain signaling.	Oxygen	41-47	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	12-18
30902795-8	2019	HSP2-treated tumors exhibited reduced oxygen consumption rates (OCR) and ATP levels.	Oxygen	38-44	heat shock protein, 2	Mus musculus	0-4
30773021-9	2019	Antioxidants and p66shc siRNA prevented SAHH inhibition-induced generation of reactive oxygen species and attenuated the impaired endothelial vasomotor responses in high-SAH mice.	Oxygen	87-93	src homology 2 domain-containing transforming protein C1	Mus musculus	17-23
30383455-2	2019	We hypothesized that intravitreal pro-angiogenic VEGF-A in microparticle form would promote earlier retinal revascularization in an oxygen-induced ischemic retinopathy (OIR) mouse model.	Oxygen	132-138	vascular endothelial growth factor A	Mus musculus	49-55
30281799-4	2019	We show that at 4 C the plant mitochondrial ATP synthase is differentially inhibited compared with other elements of the respiratory pathway, leading to decreased ADP : oxygen ratios and a limitation to the rate of ATP synthesis.	Oxygen	169-175	ATP synthase	Arabidopsis thaliana	44-56
30839176-6	2019	We tested this by measuring transport-dependent oxygen consumption (VO2 ) in TAL suspensions.	Oxygen	48-54	transaldolase 1	Homo sapiens	77-80
30806794-4	2019	Results show that the AlP co-doped graphene strictly enhances the oxygen reactivity compared to AlN one.	Oxygen	66-72	ATHS	Homo sapiens	22-25
30806794-6	2019	The CO oxidation reaction paths over the AlN and AlP-co-doped graphene have revealed that they can be regarded as the competent catalyst for CO oxidation in the presence of O2.	Oxygen	173-175	ATHS	Homo sapiens	49-52
30806794-7	2019	Mechanistically, both AlP and AlN co-doped graphene catalysts are appropriately active in the first step while the second step is too hard to do regarding the multi-center covalency character between O2 and AlP co-doped graphene and hence its catalytic efficiency is significantly lower compared to AlN co-doped graphene sheet.	Oxygen	200-202	ATHS	Homo sapiens	22-25
30828510-1	2019	NOV1, a stilbene cleavage oxygenase, catalyzes the cleavage of the central double bond of stilbenes to two phenolic aldehydes, using a 4-His Fe(II) center and dioxygen.	Oxygen	159-167	chromosome 11 putative open reading frame 40	Homo sapiens	0-4
30783090-5	2019	Furthermore, endothelial MST1-FOXO1 cascade is required for revascularization and neovascularization in the oxygen-induced retinopathy model.	Oxygen	108-114	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	25-29
30718686-5	2019	Telmisartan-treated conditioned medium (Tel-CM) of RAW264.7 cells and of bone marrow derived macrophages (BMDM) induced the expressions of browning markers in fully differentiated white adipocytes with reduced lipid droplets, and increased oxygen consumption rate and mitochondrial biogenesis.	Oxygen	240-246	ets variant 6	Mus musculus	0-3
30537002-6	2019	The TMEM180 promoter region contains 10 hypoxia-responsive element consensus sequences; accordingly, SW480 cells upregulated TMEM180 under low-oxygen conditions.	Oxygen	143-149	major facilitator superfamily domain containing 13A	Homo sapiens	4-11
30537002-6	2019	The TMEM180 promoter region contains 10 hypoxia-responsive element consensus sequences; accordingly, SW480 cells upregulated TMEM180 under low-oxygen conditions.	Oxygen	143-149	major facilitator superfamily domain containing 13A	Homo sapiens	125-132
30704538-0	2019	Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells.	Oxygen	56-62	long intergenic non-protein coding RNA 914	Homo sapiens	90-94
30937267-6	2019	Such strain-induced excessive oxygen vacancies in the LSC/STO increases the eg state occupancy and enlarges the energy gap between the O 2p and Co 3d band, resulting in lower OER activity.	Oxygen	30-36	immunoglobulin kappa variable 1D-39	Homo sapiens	135-139
30510139-8	2019	They suggest that when photosynthetic electron carriers are highly reduced, a chloroplast-mitochondria coupling allows safe dissipation of photosynthetically derived electrons via the reduction of O2 through AOX (especially AOX1)-dependent mitochondrial respiration.	Oxygen	197-199	uncharacterized protein	Chlamydomonas reinhardtii	208-211
30679723-8	2019	Placental hypoxia in the RUPP was confirmed with histological staining for hypoxia-inducible factor (HIF)-1alpha, a cellular transcription regulator which responds to local oxygen levels.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	75-112
30693322-2	2019	Metalloenzymes activate O2 by employing earth-abundant metals and exhibit diverse reactivities in oxidation reactions, including epoxidation of olefins, functionalization of alkane C-H bonds, arene hydroxylation, and syn-dihydroxylation of arenes.	Oxygen	24-26	synemin	Homo sapiens	217-220
30774414-0	2019	Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.	Oxygen	11-17	mechanistic target of rapamycin kinase	Rattus norvegicus	61-65
30379329-4	2019	However, triplet molecular oxygen of O2 (   Sigma   3  g -  ) can be produced with considerable probability through nonadiabatic intersystem crossing in the 1 Deltag /   Sigma   3  g -  intersection region.	Oxygen	27-33	immunoglobulin kappa variable 1D-39	Homo sapiens	37-61
30471863-0	2019	Overexpressing kringle 1 domain of hepatocyte growth factor with adeno-associated virus inhibits the pathological retinal neovascularization in an oxygen-induced retinopathy mouse model.	Oxygen	147-153	hepatocyte growth factor	Mus musculus	35-59
30029798-4	2019	The changes in peak oxygen uptake (PVO2: % of normal value) from CPX1 to CPX2 (1-dPVO2) and from CPX2 to CPX3 (2-dPVO2) were calculated, and then the patients were divided into four subgroups according the 1-dPVO2 and 2-dPVO2.	Oxygen	20-26	complexin 1	Homo sapiens	65-69
30029798-4	2019	The changes in peak oxygen uptake (PVO2: % of normal value) from CPX1 to CPX2 (1-dPVO2) and from CPX2 to CPX3 (2-dPVO2) were calculated, and then the patients were divided into four subgroups according the 1-dPVO2 and 2-dPVO2.	Oxygen	20-26	complexin 2	Homo sapiens	73-77
30497093-7	2019	In antioxidant conditions, the increased IL-15 expression at 120 min post-exercise (33%; P=0.017) was associated with the oxygen deficit caused by the sprint (r=-0.54; P=0.020); while, IL-15 and Tyr705-STAT3 AUCs were also related (r=0.50; P=0.036).	Oxygen	122-128	interleukin 15	Homo sapiens	41-46
31430745-5	2019	Klotho fractional enrichment across the kidney was inversely related to plasma sodium (r = 0.43, p = 0.045) and acid uric acid levels (r = 0.38, p = 0.084) and directly, to renal oxygen extraction (r = 0.56, p = 0.006).	Oxygen	179-185	klotho	Homo sapiens	0-6
31430745-6	2019	In multivariate analysis, renal oxygen extraction was the only predictor of the enrichment of Klotho across the kidney, suggesting the dependence of renal Klotho release on tubular hypoxia or oxidative metabolism.	Oxygen	32-38	klotho	Homo sapiens	94-100
31430745-6	2019	In multivariate analysis, renal oxygen extraction was the only predictor of the enrichment of Klotho across the kidney, suggesting the dependence of renal Klotho release on tubular hypoxia or oxidative metabolism.	Oxygen	32-38	klotho	Homo sapiens	155-161
31430745-9	2019	CONCLUSIONS: The present study identifies kidney oxygen uptake as a predictor of Klotho release, and splanchnic organs as a site for Klotho removal.	Oxygen	49-55	klotho	Homo sapiens	81-87
31430745-10	2019	This study provides new understanding of kidney Klotho release and suggests that modulating kidney oxygen metabolism could increase Klotho delivery, as an option to slow disease progression and blunt organ damage.	Oxygen	99-105	klotho	Homo sapiens	48-54
31430745-10	2019	This study provides new understanding of kidney Klotho release and suggests that modulating kidney oxygen metabolism could increase Klotho delivery, as an option to slow disease progression and blunt organ damage.	Oxygen	99-105	klotho	Homo sapiens	132-138
31172463-4	2019	The phagocyte oxidase complex employs a heterodimeric transmembrane protein composed of gp91phox and p22phox to relay electrons from NADPH to molecular oxygen, while other cofactors contribute to localization and regulation of the activity of the assembled oxidase.	Oxygen	152-158	cytochrome b-245 beta chain	Homo sapiens	88-96
32254161-3	2019	As a proof of concept, we study the kinetics of glucose oxidase (GOx) catalyzed reactions using a triphase system fabricated by layering GOx upon superhydrophobic mesoporous ZnO nanowire arrays through which oxygen, needed for the enzymatic reaction, is supplied directly from the atmosphere to the liquid-solid interface.	Oxygen	208-214	hydroxyacid oxidase 1	Homo sapiens	48-63
32254161-3	2019	As a proof of concept, we study the kinetics of glucose oxidase (GOx) catalyzed reactions using a triphase system fabricated by layering GOx upon superhydrophobic mesoporous ZnO nanowire arrays through which oxygen, needed for the enzymatic reaction, is supplied directly from the atmosphere to the liquid-solid interface.	Oxygen	208-214	hydroxyacid oxidase 1	Homo sapiens	65-68
30543812-7	2019	Cox-proportional hazard models were performed to determine the association between the change in CRF, computed as visit 1 (CPX1) peak oxygen consumption (VO2peak [mL kg-1 min-1]) - visit 2 (CPX2) VO2peak, and mortality outcomes.	Oxygen	134-140	complexin 1	Homo sapiens	123-127
30655714-8	2019	A correlation exists between tyrosinase expression and O2 consumption during B. bufo development.	Oxygen	55-57	tyrosinase	Homo sapiens	29-39
30651902-0	2018	Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-kappaB/p65 Signaling in Chronic Radiculitis Rats.	Oxygen	18-24	phosphodiesterase 2A	Rattus norvegicus	93-103
30466402-11	2018	CONCLUSIONS: Pulse wave analysis indicated peripheral vasodilation and increased cardiac output after oxytocin, implying increased myocardial oxygen demand.	Oxygen	142-148	oxytocin/neurophysin I prepropeptide	Homo sapiens	102-110
31815054-8	2018	GOx-assisted oxygen removal in the synthesis of hydrophobic polymers is reported for the first time.	Oxygen	13-19	hydroxyacid oxidase 1	Homo sapiens	0-3
30983367-3	2019	It showed that PAM+ not only played an important role in good nucleation that brought well-developed texture and novel pore size distribution to SS-MBCs but also improved the MB adsorption capacities of SS-MBCs by increasing the specific surface area and the content of oxygen functional groups, especially the lactone.	Oxygen	270-276	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	15-18
31009214-1	2019	The reaction of [Ni(COD)2] (COD; cyclooctadiene) in THF with the NNN-pincer ligand bis(imino)pyridyl (L1) reveals a susceptibility to oxidation in an inert atmosphere ([O2] level &lt;0.5 ppm), resulting in a transient Ni:dioxygen adduct.	Oxygen	169-171	COD2	Homo sapiens	20-25
30360047-3	2018	However, simultaneous improvement on the electrical and mechanical properties of low-density GCNT is still a great challenge owing to their disordered microstructure, severe structural defects and massive oxygen-containing functional groups.	Oxygen	205-211	glucosaminyl (N-acetyl) transferase family member 7	Homo sapiens	93-97
16723075-1	2006	OBJECTIVE: To explore the effects of hyperbaric oxygen (HBO) treatment on the neuronal apoptosis at an earlier stage and the expressions of Cytochrome C (Cyt C), Bcl-2 (B-cell lymphoma-2 family) and Bax (Bcl-2 associated X protein) in rat brain tissues after traumatic brain injury (TBI).	Oxygen	48-54	BCL2 associated X, apoptosis regulator	Rattus norvegicus	199-202
16724053-2	2006	The mTOR protein kinase has emerged as a critical growth-control node, receiving stimulatory signals from Ras and phosphatidylinositol-3-OH kinase (PI(3)K) downstream from growth factors, as well as nutrient inputs in the form of amino-acid, glucose and oxygen availability.	Oxygen	254-260	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	114-146
30109776-3	2018	In this paper, exceptionally active electrocatalysts for oxygen-evolution reactions (OERs) were successfully developed and characterized by using SEM, TEM, XRD, BET, and X-ray photoelectron spectroscopy.	Oxygen	57-63	MFT2	Homo sapiens	151-154
31218102-3	2019	Here, we report that miR-873 promotes Warburg effect in HCC cells by increasing glucose uptake, extracellular acidification rate (ECAR), lactate production, and ATP generation, and decreasing oxygen consumption rate (OCR) in HCC cells.	Oxygen	192-198	microRNA 873	Homo sapiens	21-28
30503171-6	2019	The number of ICAM-1 positive ASCs was increased under low O2 as well.	Oxygen	59-61	intercellular adhesion molecule 1	Homo sapiens	14-20
16467961-6	2006	FINDINGS: In 4 MD patients and one non-MD patient, the STA blood flow increased the oxyhaemoglobin and cortical oxygen saturation (CoSO2), indicating that the bypass supplied blood flow to the ischaemic brain; the CBO changes were observed more frequently in MD than in non-MD patients (p&lt;0.02).	Oxygen	112-118	GCY	Homo sapiens	55-58
30896865-13	2019	However, there were significant differences in the expression levels of both phosphorylated forms of PKD1 under different oxygen conditions in the controls.	Oxygen	122-128	protein kinase D1	Homo sapiens	101-105
30842265-3	2019	electrophoretic mobility shift assay and luciferase reporter analysis illustrate that TaBZR2 directly interacts with the gene promoter to activate the expression of T. aestivum glutathione s-transferase-1 (TaGST1), which functions positively in scavenging drought-induced superoxide anions (O2 -).	Oxygen	291-295	glutathione S-transferase 1	Triticum aestivum	206-212
30283922-3	2018	DA was easily oxidized to DA quinone under the catalysis of TYR by dissolved O2, which effectively quenched the fluorescence of the QDs.	Oxygen	77-79	tyrosinase	Homo sapiens	60-63
16771669-6	2006	The oxygen content as well as the redox and oxidative stresses regulate RNR activity and synthesis in various organisms.	Oxygen	4-10	nuclear receptor subfamily 2 group E member 3	Homo sapiens	72-75
30183286-3	2018	The computations supported by NBO analysis showed that intrinsic stability of the predominant trans isomer (alphaD and C7beta forms) of the dipeptoid model results from an indirect n   pi* interaction, occurring between the carbonyl oxygen lone pair ( n) and the pi* orbital of the adjacent amide carbonyl through the C-H antibond (sigma*).	Oxygen	233-239	endogenous retrovirus group K member 14	Homo sapiens	119-125
31009360-12	2019	By contrast, IPC induced SOCE and Ca2+ release-activated Ca2+current upregulation, thereby preventing STIM1 and ORAI1 downregulation induced by oxygen and glucose deprivation+reoxygenation.	Oxygen	144-150	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	112-117
16641134-2	2006	Its catalytic component, responsible for the NADPH-driven reduction of oxygen to O2*-, is flavocytochrome b559, located in the membrane and consisting of gp91phox and p22phox subunits.	Oxygen	71-77	cytochrome b-245 alpha chain	Homo sapiens	167-174
30719775-3	2019	As a proof-of-concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2 )-sensitive, noble-metal-free, luminescent CuI triazolate framework (MAF-2), denoted as GOx@MAF-2.	Oxygen	80-86	hydroxyacid oxidase 1	Homo sapiens	23-38
30719775-3	2019	As a proof-of-concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2 )-sensitive, noble-metal-free, luminescent CuI triazolate framework (MAF-2), denoted as GOx@MAF-2.	Oxygen	80-86	hydroxyacid oxidase 1	Homo sapiens	40-43
30719775-3	2019	As a proof-of-concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2 )-sensitive, noble-metal-free, luminescent CuI triazolate framework (MAF-2), denoted as GOx@MAF-2.	Oxygen	88-90	hydroxyacid oxidase 1	Homo sapiens	23-38
30719775-3	2019	As a proof-of-concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2 )-sensitive, noble-metal-free, luminescent CuI triazolate framework (MAF-2), denoted as GOx@MAF-2.	Oxygen	88-90	hydroxyacid oxidase 1	Homo sapiens	40-43
30719775-5	2019	More importantly, owing to the O2 sensitivity of MAF-2, the GOx@MAF-2 composite exhibited a rapid and reversible response towards dissolved O2 , thereby allowing direct and ratiometric sensing of glucose without the need for chromogenic substrates, cascade enzymatic reactions, or electrode systems.	Oxygen	31-33	hydroxyacid oxidase 1	Homo sapiens	60-63
30719775-5	2019	More importantly, owing to the O2 sensitivity of MAF-2, the GOx@MAF-2 composite exhibited a rapid and reversible response towards dissolved O2 , thereby allowing direct and ratiometric sensing of glucose without the need for chromogenic substrates, cascade enzymatic reactions, or electrode systems.	Oxygen	140-142	hydroxyacid oxidase 1	Homo sapiens	60-63
30199618-0	2018	Selective SnO x Atomic Layer Deposition Driven by Oxygen Reactants.	Oxygen	50-56	strawberry notch homolog 2	Homo sapiens	10-13
29959868-4	2018	To design optimized enzyme-mediator couples and to describe a mediator binding model, a joint experimental and computational study was performed based on an oxygen-independent GOx variant V7 and two quinone diimine based electron mediators (QDM-1 and QDM-2), which differ in polarity and size, and ferrocenemethanol (FM).	Oxygen	157-163	hydroxyacid oxidase 1	Homo sapiens	176-179
30322799-9	2018	INTERPRETATION: Based on our findings, SGLT2 inhibitors may alter glomerular distribution and size in addition to their glucose-lowering effects, presumably by affecting oxygen metabolism and humoral factors.	Oxygen	170-176	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	39-44
30132575-2	2018	Hypoxia-inducible factor 1alpha (HIF1-alpha) is induced when cells are exposed to low O2 concentrations.	Oxygen	86-88	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
30132575-2	2018	Hypoxia-inducible factor 1alpha (HIF1-alpha) is induced when cells are exposed to low O2 concentrations.	Oxygen	86-88	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
30732813-4	2019	Such unique structure endows GONS/CNF nanocomposites with ultrahigh oxygen barrier property and good water vapor barrier performance.	Oxygen	68-74	NPHS1 adhesion molecule, nephrin	Homo sapiens	34-37
30732813-5	2019	With only 3.66 vol% GONS, the oxygen permeability coefficient of CNF film decreased by about 4 x 104 times, from 5.5 x 10-13 to 1.4 x 10-17  cm3 cm cm-2 s-1  Pa-1.	Oxygen	30-36	NPHS1 adhesion molecule, nephrin	Homo sapiens	65-68
16344008-10	2006	)V(O(2)(max) of HCR was an increased tissue O(2) extraction, due largely to a higher tissue diffusive O(2) conductance.	Oxygen	3-7	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	16-19
30677507-9	2019	While mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH) mediated oxygen flux was greatest in wasps, muscle fibres released greater amounts of ROS through this pathway.	Oxygen	72-78	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	56-61
29908404-6	2018	Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity.	Oxygen	258-264	oxytocin/neurophysin I prepropeptide	Homo sapiens	118-126
29908404-6	2018	Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity.	Oxygen	258-264	oxytocin/neurophysin I prepropeptide	Homo sapiens	448-456
16344008-11	2006	The enhanced tissue O(2) diffusing capacity was paralleled by an increased capillary density of a representative locomotory skeletal muscle, the gastrocnemius, in HCR.	Oxygen	20-24	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	163-166
30838481-9	2019	Moreover, both cytoskeletal rearrangement and reactive oxygen species production are partially impaired in DOCK2-deficient neutrophils.	Oxygen	55-61	dedicator of cytokinesis 2	Homo sapiens	107-112
16344008-13	2006	Thus, the functional characteristics observed during exercise are consistent with the structural and biochemical changes observed in skeletal muscle that imply an enhanced capacity for muscle O(2) uptake and utilization in HCR.	Oxygen	192-196	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	223-226
16626125-1	2006	Regioselective reductive openings of mixed phenolic-benzylic acetals, using BH3.NMe3-AlCl3, was investigated, and a mechanism where the outcome is directed by the electrostatic potential of the two oxygen atoms is presented.	Oxygen	198-204	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	80-84
30707772-8	2019	We conclude that PHOX2B-derived astrocytes are necessary for maintaining a functional O2 chemosensory reflex in the adult, modulate sleep homeostasis, and are key regulators of synaptic integrity in the RTN region, which is necessary for the chemosensory control of breathing.	Oxygen	86-88	paired-like homeobox 2b	Mus musculus	17-23
30355102-10	2018	Results- Experimental stroke and oxygen and glucose deprivation induced the expression of MDM2 in the brain and neurons, respectively.	Oxygen	33-39	MDM2 proto-oncogene	Homo sapiens	90-94
30355102-11	2018	Moreover, oxygen and glucose deprivation promoted MDM2 binding with p53 in neurons.	Oxygen	10-16	MDM2 proto-oncogene	Homo sapiens	50-54
30355102-12	2018	Disruption of the MDM2-p53 interaction with nutlin-3a, or MDM2 knockdown by siRNA, triggered p53 accumulation, which increased neuronal susceptibility to oxygen and glucose deprivation-induced apoptosis.	Oxygen	154-160	MDM2 proto-oncogene	Homo sapiens	18-22
30355102-12	2018	Disruption of the MDM2-p53 interaction with nutlin-3a, or MDM2 knockdown by siRNA, triggered p53 accumulation, which increased neuronal susceptibility to oxygen and glucose deprivation-induced apoptosis.	Oxygen	154-160	MDM2 proto-oncogene	Homo sapiens	58-62
29908295-7	2018	Thus, intracellular hyperglycaemia, that can be prevented with an inhibitor of the SGLT2 cotransporter that was identified in the vascular tissue and tissue-derived cultured endothelial cells by qPCR, western blot and immunohistochemistry, leads to oxidative stress that compromises PAR2-mediated NOS-dependent vasodilation by an NAPDH oxidase/reactive-oxygen-species-triggered signalling pathway involving EGFR/Src/Rho-kinase and PKC.	Oxygen	353-359	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	83-88
30770219-8	2019	The action of Wnt/beta-catenin was dependent on the receptor of advanced glycation end products (RAGE)-mediated NADPH oxidase induction, reactive oxygen species generation, and nuclear factor-kappaB activation.	Oxygen	146-152	catenin (cadherin associated protein), beta 1	Mus musculus	18-30
16608943-9	2006	Furthermore, P-selectin correlated with AHI (r = 0.32, p &lt; 0.001), respiratory arousal index (r = 0.27, p = 0.002), and nadir of oxygen saturation as measured by pulse oximetry (r = - 0.19, p = 0.038).	Oxygen	132-138	selectin P	Homo sapiens	13-23
31096390-4	2019	Experimental results show that the addition of hematite as oxygen carrier (OC) favors the production of H2 and CO.	Oxygen	59-65	relaxin 2	Homo sapiens	104-113
30256441-8	2018	We further show that dysregulated mitochondrial fusion by Mfn2 knockdowns suppressed the oxygen consumption rate of melanoma cells.	Oxygen	89-95	mitofusin 2	Homo sapiens	58-62
16403519-5	2006	However, DJ-1 is very susceptible to oxidation by the addition of two oxygen atoms to form the sulfinic acid of Cys106 (2O DJ-1) (no 1O oxidized state is detectable).	Oxygen	70-76	Parkinsonism associated deglycase	Homo sapiens	9-13
30323966-7	2018	Further, by inhibiting PDK4 expression, miR-211 promotes a phenotype shift towards a pro-glycolytic state evidenced by decreased extracellular acidification rate (ECAR); increased oxygen consumption rate (OCR); and increased spare respiratory capacity in breast cancer cell lines.	Oxygen	180-186	microRNA 211	Homo sapiens	40-47
30937375-6	2019	Diabetic wounds treated with the PCN-miR/Col demonstrate a remarkably accelerated wound closure and enhanced quality of the healed wound as featured by highly ordered alignment of collagen fiber, skin appendage morphogenesis, functional new blood vessel growth, and oxygen saturation.	Oxygen	266-272	membrane associated ring-CH-type finger 8	Homo sapiens	37-40
16511306-1	2006	Indoleamine 2,3-dioxygenase (IDO) is a haem-containing dioxygenase that catalyzes the oxidative cleavage of the pyrrole ring of indoleamines by the insertion of molecular oxygen.	Oxygen	18-24	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
30830763-1	2019	Poor O2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1alpha) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation.	Oxygen	5-7	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	137-147
30984416-3	2019	Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis.	Oxygen	117-123	cytochrome b-245 beta chain	Homo sapiens	51-66
30984416-3	2019	Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis.	Oxygen	117-123	cytochrome b-245 beta chain	Homo sapiens	68-72
30865742-4	2019	In the slightly acidic environment of cancer cells, GOx is released and it consumes d-glucose and molecular oxygen, nutrients essential for the survival of cancer cells, and produces gluconic acid and hydrogen peroxide, respectively.	Oxygen	108-114	hydroxyacid oxidase 1	Homo sapiens	52-55
29786753-6	2018	In vitro, the expression of CXCR4 at the mRNA and protein levels was increased in JEG3 cells exposed to 3% O2 in a time-dependent manner, and the migratory and invasive abilities of the JEG3 cells were upregulated.	Oxygen	107-109	C-X-C motif chemokine receptor 4	Homo sapiens	28-33
29786753-7	2018	In addition, CXCR4 knockdown by transfection with CXCR4-specific small interfering (si)RNA decreased the migration and invasion of JEG3 cells exposed to 3% O2.	Oxygen	156-158	C-X-C motif chemokine receptor 4	Homo sapiens	13-18
29786753-7	2018	In addition, CXCR4 knockdown by transfection with CXCR4-specific small interfering (si)RNA decreased the migration and invasion of JEG3 cells exposed to 3% O2.	Oxygen	156-158	C-X-C motif chemokine receptor 4	Homo sapiens	50-55
29786753-8	2018	Furthermore, synthetic siRNA specific for HIF-1alpha significantly suppressed the expression of CXCR4 in JEG3 cells exposed to 3% O2, whereas pcDNA-HIF-1alpha significantly increased the expression of CXCR4.	Oxygen	130-132	C-X-C motif chemokine receptor 4	Homo sapiens	96-101
29677776-2	2018	The oxygen content of the Fe powders heat-treated in Ar and Ar-H2 atmosphere was much lower than that of the Fe powder heat-treated in air atmosphere.	Oxygen	4-10	ADP-ribosylhydrolase like 1	Homo sapiens	60-65
32863537-4	2019	The RBC hemoglobin oxygen saturation determines the hemoglobin molecular magnetic susceptibility (diamagnetic when fully oxygenated, paramagnetic when fully deoxygenated or converted to methemoglobin).	Oxygen	19-25	hemoglobin subunit gamma 2	Homo sapiens	186-199
16195499-3	2006	Hypoxia-inducible factor (HIF)-1alpha mRNA was highly expressed in the placenta, whereas HIF-2alpha was predominantly found in the decidua, indicating that HIF-1 is a relevant oxygen-dependent factor involved in placental development.	Oxygen	176-182	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-37
30810130-7	2019	The results indicated that molecular oxygen preferentially interacts with graphite defects, which involve the pi-electron system and accumulation of the spin density on the edges of the grains, in particular, on the zig-zag edges present on ball-milled graphite.	Oxygen	37-43	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	220-223
30060096-4	2018	The expression of genes encoding prorenin (REN), angiotensinogen, (pro)renin receptor, angiotensin converting enzyme 2, and the angiotensin II type 1 receptor are highest in early gestation, at a time when oxygen tension is at its lowest.	Oxygen	206-212	ATPase H+ transporting accessory protein 2	Homo sapiens	49-118
29859868-6	2018	Moreover, CPF (10 muM) induced time-dependent increase in STAT1 activation coincided with the collapse of mitochondrial transmembrane potential, increase in ROS generation, proteolytic cleavage of protein kinase C delta (PKCdelta), inhibition of the mitochondrial basal oxygen consumption rate (OCR), with a concomitant reduction in ATP-linked OCR and reserve capacity, increase in Bax/Bcl-2 ratio and enhancement of autophagy.	Oxygen	270-276	signal transducer and activator of transcription 1	Homo sapiens	58-63
16195499-3	2006	Hypoxia-inducible factor (HIF)-1alpha mRNA was highly expressed in the placenta, whereas HIF-2alpha was predominantly found in the decidua, indicating that HIF-1 is a relevant oxygen-dependent factor involved in placental development.	Oxygen	176-182	endothelial PAS domain protein 1	Mus musculus	89-99
30617181-3	2019	In the canonical HIF signaling pathway, HIF-prolyl hydroxylase 3 (PHD3) suppresses HIF-2alpha protein by post-translational hydroxylation under sufficient oxygen availability.	Oxygen	155-161	egl-9 family hypoxia inducible factor 3	Homo sapiens	40-64
16199475-6	2006	Biochemical assessment of the VLCAD(/- mice BAT showed increased oxygen consumption, attributed to uncoupled respiration in the absence of stress.	Oxygen	65-71	acyl-Coenzyme A dehydrogenase, very long chain	Mus musculus	30-35
30617181-3	2019	In the canonical HIF signaling pathway, HIF-prolyl hydroxylase 3 (PHD3) suppresses HIF-2alpha protein by post-translational hydroxylation under sufficient oxygen availability.	Oxygen	155-161	egl-9 family hypoxia inducible factor 3	Homo sapiens	66-70
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	87-89	POU domain, class 5, transcription factor 1	Mus musculus	55-61
29880462-9	2018	Furthermore, the expression levels of Mmp-9, Nanog and Pou5f1 showed an increase in 5% O2 in comparison with 20% O2 group.	Oxygen	113-115	POU domain, class 5, transcription factor 1	Mus musculus	55-61
16415905-0	2006	A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.	Oxygen	80-86	carbonic anhydrase 1	Rattus norvegicus	122-125
29302924-8	2018	Univariate analysis showed that serum Romo1 was positively correlated with apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent below 90% oxygen saturation (Ts90%), arousal index, ROS, and CRP, and was negatively correlated with minimal oxygen saturation (miniSaO2) (all P &lt; 0.05).	Oxygen	103-109	reactive oxygen species modulator 1	Homo sapiens	38-43
29302924-8	2018	Univariate analysis showed that serum Romo1 was positively correlated with apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent below 90% oxygen saturation (Ts90%), arousal index, ROS, and CRP, and was negatively correlated with minimal oxygen saturation (miniSaO2) (all P &lt; 0.05).	Oxygen	157-163	reactive oxygen species modulator 1	Homo sapiens	38-43
30656931-3	2019	A differential trapping method was applied to remove major interfering substances such as CO2, N2, and O2 in order to ensure sufficient sampling volume of secondary injection trap.	Oxygen	91-93	TRAP	Homo sapiens	15-19
16505234-4	2006	When c-Cbl(-/-) mice were fed a high-fat diet for 4 weeks, they maintained hyperphagia, higher whole-body oxygen consumption (27%), and greater activity (threefold) compared with wild-type animals fed the same diet.	Oxygen	106-112	Casitas B-lineage lymphoma	Mus musculus	5-10
30663118-4	2019	Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2 O2 to generate O2 , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell.	Oxygen	170-172	toll-like receptor 7	Mus musculus	257-277
29302924-8	2018	Univariate analysis showed that serum Romo1 was positively correlated with apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent below 90% oxygen saturation (Ts90%), arousal index, ROS, and CRP, and was negatively correlated with minimal oxygen saturation (miniSaO2) (all P &lt; 0.05).	Oxygen	157-163	reactive oxygen species modulator 1	Homo sapiens	38-43
30135298-8	2018	Strikingly, PPARgamma inhibition reversed hepatic Aloxe3-mediated insulin sensitization, suppression of hepatocellular ATP production and oxygen consumption, and gene induction of PPARgamma coactivator-1alpha (PGC1alpha) expression.	Oxygen	138-144	arachidonate lipoxygenase 3	Mus musculus	50-56
29675549-8	2018	Moreover, intravitreal injection of small interfering RNA of SNAI1 suppressed new vessel formation in developing retina as well as mice model of choroidal neovascularization and oxygen-induced retinopathy.	Oxygen	178-184	snail family zinc finger 1	Mus musculus	61-66
29374630-10	2019	BM transplantation experiments and cellular reactive oxygen species assays revealed effects of TREM-2 in the context of chronic injury depended on both immune and resident TREM-2 expression.	Oxygen	53-59	triggering receptor expressed on myeloid cells 2	Mus musculus	95-101
30592266-0	2019	Normobaric oxygen inhibits AQP4 and NHE1 expression in experimental focal ischemic stroke.	Oxygen	11-17	solute carrier family 9 member A1	Rattus norvegicus	36-40
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Oxygen	308-314	colony stimulating factor 3 receptor	Homo sapiens	161-167
30016042-2	2018	Methemoglobinemia is a disorder that occurs when hemoglobin in the blood is oxidized to form methemoglobin, rendering it unable to transport oxygen.	Oxygen	141-147	hemoglobin subunit gamma 2	Homo sapiens	93-106
30813573-4	2019	While the C-C bond formation involving the beta-conjugated carbon of alpha-santonin derivative is more favorable than the C-O one, which is responsible for the ortho regioselectivity, the favorable electronic interactions taking place between the oxygen of the nitrile oxide and two axial hydrogen atoms of the alpha-santonin derivative are responsible for the syn diastereofacial selectivity.	Oxygen	247-253	synemin	Homo sapiens	361-364
16477023-0	2006	Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.	Oxygen	79-81	indoleamine 2,3-dioxygenase 1	Homo sapiens	27-54
30674187-2	2019	Glucose oxidase (GOx) can inexpensively enable radical polymerization in solution by enzymatically consuming oxygen as it oxidizes glucose.	Oxygen	109-115	hydroxyacid oxidase 1	Homo sapiens	0-15
29444807-1	2018	OBJECTIVE: Commercial airplanes fly with an equivalent cabin fraction of inspired oxygen of 0.15, leading to reduced oxygen saturation (SpO2) in passengers.	Oxygen	82-88	spookier	Drosophila melanogaster	136-140
29444807-1	2018	OBJECTIVE: Commercial airplanes fly with an equivalent cabin fraction of inspired oxygen of 0.15, leading to reduced oxygen saturation (SpO2) in passengers.	Oxygen	117-123	spookier	Drosophila melanogaster	136-140
30674187-2	2019	Glucose oxidase (GOx) can inexpensively enable radical polymerization in solution by enzymatically consuming oxygen as it oxidizes glucose.	Oxygen	109-115	hydroxyacid oxidase 1	Homo sapiens	17-20
16477023-1	2006	Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a molecule of oxygen (O2).	Oxygen	24-30	indoleamine 2,3-dioxygenase 1	Homo sapiens	35-38
29722626-6	2018	ClC-1 abundance correlated negatively ( P < 0.01) with maximal oxygen consumption ( r = -0.552) and incremental exercise performance ( r = -0.546).	Oxygen	63-69	chloride voltage-gated channel 1	Homo sapiens	0-5
16477023-1	2006	Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a molecule of oxygen (O2).	Oxygen	144-146	indoleamine 2,3-dioxygenase 1	Homo sapiens	6-33
16477023-1	2006	Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a molecule of oxygen (O2).	Oxygen	144-146	indoleamine 2,3-dioxygenase 1	Homo sapiens	35-38
31250610-0	2019	[Effects of Notch signal on the expressions of HIF-alpha and autophagy- related genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation induced myocardial cell injury].	Oxygen	110-116	beclin 1	Homo sapiens	86-93
16477023-6	2006	These characteristics of the IDO structure provide support for a reaction mechanism involving the abstraction of a proton from the substrate by iron-bound dioxygen.	Oxygen	155-163	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
16471801-4	2006	Compared with other Mb layer-by-layer films with nonconductive nanoparticles or polyions, {Au/Mb}n films showed much improved properties, such as smaller electron-transfer resistance (Rct) measured by EIS with Fe(CN)3-/4- redox probe, higher maximum surface concentration of electroactive Mb (Gamma*max), and better electrocatalytic activity toward reduction of O2 and H2O2, mainly because of the good conductivity of Au nanoparticles.	Oxygen	362-364	myoglobin	Homo sapiens	94-96
31343364-0	2019	Serum diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in patients with ATTR-PN.	Oxygen	23-29	transthyretin	Homo sapiens	111-115
29665051-5	2018	Mechanistic studies revealed that the sensitizing effect of hyperbaric oxygen is due to decreased ratio of Bcl-2/Bax, increased level of p53, cleaved Caspase3, GRP78, CHOP, and LC3.	Oxygen	71-77	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	177-180
29905078-6	2018	We also explore the use of a highly efficient SOT generator, oxygen-doped tungsten in the three-terminal device geometry, confirming its -50% spin Hall angle.	Oxygen	61-67	spindlin 1	Homo sapiens	142-146
16471801-4	2006	Compared with other Mb layer-by-layer films with nonconductive nanoparticles or polyions, {Au/Mb}n films showed much improved properties, such as smaller electron-transfer resistance (Rct) measured by EIS with Fe(CN)3-/4- redox probe, higher maximum surface concentration of electroactive Mb (Gamma*max), and better electrocatalytic activity toward reduction of O2 and H2O2, mainly because of the good conductivity of Au nanoparticles.	Oxygen	362-364	myoglobin	Homo sapiens	94-96
16251499-0	2006	Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration.	Oxygen	85-91	CD274 molecule	Homo sapiens	12-17
29750865-5	2018	Amperometric measurements using the GOx biosensor were performed at -0.7 V by following the oxygen consumption due to the enzymatic reaction in different glucose concentrations.	Oxygen	92-98	hydroxyacid oxidase 1	Homo sapiens	36-39
30160213-8	2019	Dopamine metabolism by MAOB generates reactive oxygen species, which contribute to nigro-striatal degeneration.	Oxygen	47-53	monoamine oxidase B	Homo sapiens	23-27
16251499-0	2006	Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration.	Oxygen	85-91	CD274 molecule	Homo sapiens	19-24
30209781-10	2019	All five patients required oxygen therapy with the use of CPAP and BiPAP also seen.	Oxygen	27-33	centromere protein J	Homo sapiens	58-62
16251499-4	2006	As this coincides with the expected onset of maternal blood flow to the placenta and a corresponding rise in local oxygen tension, we explored the possibility that oxygen regulates CD274 expression in trophoblast cells by culturing term trophoblast cells under oxygen concentrations similar to those found in vivo.	Oxygen	164-170	CD274 molecule	Homo sapiens	181-186
29733595-0	2018	Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.	Oxygen	22-28	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	121-160
30019944-7	2018	The results of the interaction potential surface map analysis showed that the nitrogen and oxygen atoms have a relatively similar role in the binding of ligands to the CCR5 protein structure.	Oxygen	91-97	C-C motif chemokine receptor 5	Homo sapiens	168-172
31815118-2	2019	Key transcription factors that recognize xenobiotics or xenobiotic-induced stress such as reactive oxygen species (ROS), include AhR, PXR, CAR, MTF, Nrf2, NF-kappaB, and AP-1.	Oxygen	99-105	metallothionein 1L, pseudogene	Homo sapiens	144-147
30648612-2	2019	The low oxygen-induced transcriptional regulator LoiA is established to be a positive regulator of SPI-1 genes and can also repress the expression of the ATP-dependent Lon protease, a negative regulator of SPI-1 genes.	Oxygen	8-14	lon peptidase 1, mitochondrial	Mus musculus	168-171
30640062-2	2019	We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hydroxymethylcytosine (5hmC).	Oxygen	61-67	lysine demethylase 4C	Homo sapiens	255-260
16251499-4	2006	As this coincides with the expected onset of maternal blood flow to the placenta and a corresponding rise in local oxygen tension, we explored the possibility that oxygen regulates CD274 expression in trophoblast cells by culturing term trophoblast cells under oxygen concentrations similar to those found in vivo.	Oxygen	164-170	CD274 molecule	Homo sapiens	181-186
30640062-2	2019	We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hydroxymethylcytosine (5hmC).	Oxygen	152-154	lysine demethylase 4C	Homo sapiens	255-260
30640062-6	2019	Transient ectopic expression of KDM4C or TET1 in ambient atmospheric oxygen achieved the same.	Oxygen	69-75	lysine demethylase 4C	Homo sapiens	32-37
29967190-0	2018	Correction: FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.	Oxygen	22-28	euchromatic histone lysine methyltransferase 2	Homo sapiens	58-61
16251499-5	2006	Indeed, CD274 protein levels paralleled the in vivo situation: expression increased with rising oxygen concentrations.	Oxygen	96-102	CD274 molecule	Homo sapiens	8-13
16251499-6	2006	Furthermore, downregulation of CD274 mRNA by low oxygen was rapid, occurring within 4-12 h. We conclude that oxygen is a potential mediator of CD274 expression in vivo such that it is induced coincidentally on exposure of fetal tissues to maternal blood.	Oxygen	49-55	CD274 molecule	Homo sapiens	31-36
16251499-6	2006	Furthermore, downregulation of CD274 mRNA by low oxygen was rapid, occurring within 4-12 h. We conclude that oxygen is a potential mediator of CD274 expression in vivo such that it is induced coincidentally on exposure of fetal tissues to maternal blood.	Oxygen	49-55	CD274 molecule	Homo sapiens	143-148
29746630-7	2018	Conditioned medium of oxygen-glucose deprivation (OGD)-treated wild-type (WT) neurons induced M1 polarization, while that of RIPK3-/- neurons favored M2 polarization.	Oxygen	22-28	receptor interacting serine/threonine kinase 3	Homo sapiens	125-130
32255961-2	2019	Cyp1b1-deficient (Cyp1b1-/-) mice show dysgenesis of the trabecular meshwork (TM) tissue and attenuation of retinal neovascularization during oxygen-induced ischemic retinopathy (OIR).	Oxygen	142-148	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	0-6
32255961-2	2019	Cyp1b1-deficient (Cyp1b1-/-) mice show dysgenesis of the trabecular meshwork (TM) tissue and attenuation of retinal neovascularization during oxygen-induced ischemic retinopathy (OIR).	Oxygen	142-148	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	18-24
16251499-6	2006	Furthermore, downregulation of CD274 mRNA by low oxygen was rapid, occurring within 4-12 h. We conclude that oxygen is a potential mediator of CD274 expression in vivo such that it is induced coincidentally on exposure of fetal tissues to maternal blood.	Oxygen	109-115	CD274 molecule	Homo sapiens	31-36
16251499-6	2006	Furthermore, downregulation of CD274 mRNA by low oxygen was rapid, occurring within 4-12 h. We conclude that oxygen is a potential mediator of CD274 expression in vivo such that it is induced coincidentally on exposure of fetal tissues to maternal blood.	Oxygen	109-115	CD274 molecule	Homo sapiens	143-148
16282331-1	2006	The oxygen-evolving complex of eukaryotic photosystem II (PSII) consists of three extrinsic nuclear-encoded subunits, PsbO (33 kDa), PsbP (23 kDa), and PsbQ (17 kDa).	Oxygen	4-10	photosystem II subunit QA	Arabidopsis thaliana	152-156
30564959-3	2018	Dimethyloxalylglycine (DMOG) small molecule regulates the stability of HIF-1alpha at normal oxygen tension by mimicking hypoxia, which subsequently accelerates angiogenesis.	Oxygen	92-98	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	71-81
29702470-3	2018	As a result of the enzymatic reaction between GOx and glucose, the glucose amount was determined by monitoring the change in the oxygen level associated with substrate concentration via the amperometric detection technique.	Oxygen	129-135	hydroxyacid oxidase 1	Homo sapiens	46-49
16809130-1	2006	PEG-hemoglobin SB1 (SB1) is a polyethylene glycol (PEG)-modified hemoglobin-based oxygen carrier, intended for use as resuscitation fluid for brain stroke and as a blood substitute.	Oxygen	82-88	Sh3kbp1 binding protein 1	Rattus norvegicus	15-18
29983767-8	2018	The mean lowest oxygen (O 2 ) saturation level increased significantly from 66.8 +- 11.3 to 83.2 +- 2.86 ( p  &lt; 0.0001).	Oxygen	16-22	immunoglobulin kappa variable 1D-39	Homo sapiens	24-27
29981208-6	2018	Our results showed that reduced nephrin and podoplanin expression were associated with downregulation of CuZn-SOD expression in podocytes when cells were cultured under lowered oxygen or hypoxic conditions.	Oxygen	177-183	NPHS1 adhesion molecule, nephrin	Homo sapiens	32-39
30268775-7	2018	In vitro modeling of Cox10 deletion in primary kidney epithelium compromises oxygen consumption, ATP generation, and induces oxidative stress.	Oxygen	77-83	heme A:farnesyltransferase cytochrome c oxidase assembly factor 10	Mus musculus	21-26
30251652-9	2018	Assessment of lactate production and oxygen consumption demonstrated that LMW-PTP silencing enhances glycolytic flux and slow down the oxidative metabolism.	Oxygen	37-43	acid phosphatase 1	Homo sapiens	74-81
16809130-1	2006	PEG-hemoglobin SB1 (SB1) is a polyethylene glycol (PEG)-modified hemoglobin-based oxygen carrier, intended for use as resuscitation fluid for brain stroke and as a blood substitute.	Oxygen	82-88	Sh3kbp1 binding protein 1	Rattus norvegicus	20-23
17018414-5	2006	The BOD5/TOC (5-day biological oxygen demand/total organic carbons) ratios of the ozonated Reactive Red 120 and Acid Red 299 solutions would increase and have the maximum values.	Oxygen	31-37	RNA binding motif protein 25	Homo sapiens	100-107
30243381-1	2018	Catalase catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Oxygen	71-77	AKO65_RS18850	Bacillus pumilus	0-8
30065132-6	2018	The results of the measurement of dissolved oxygen (DO) profiles at different points of the B-MBR apparatus indicate that the increase in DO concentration in the anoxic zone of the B-MBR becomes much more pronounced by increasing recirculation intensity.	Oxygen	44-50	translocator protein	Homo sapiens	94-97
30065132-6	2018	The results of the measurement of dissolved oxygen (DO) profiles at different points of the B-MBR apparatus indicate that the increase in DO concentration in the anoxic zone of the B-MBR becomes much more pronounced by increasing recirculation intensity.	Oxygen	44-50	translocator protein	Homo sapiens	183-186
30147267-9	2018	A hypoxic precondition (1% O2) in culture increases CXCR4 (p=0.000) and SDF-1 expression than normoxic conditions (p=0.000) (p&lt;0.05).	Oxygen	27-29	C-X-C motif chemokine receptor 4	Rattus norvegicus	52-57
30147267-10	2018	Conclusion: Hypoxic preconditioning with 1% O2 increase CXCR4 and SDF1 expression.	Oxygen	44-46	C-X-C motif chemokine receptor 4	Rattus norvegicus	56-61
30342189-8	2018	The reaction of CBZ with GSH and NAC is more extensive in the presence of oxygen.	Oxygen	74-80	X-linked Kx blood group	Homo sapiens	33-36
30359906-0	2018	Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors.	Oxygen	0-6	spindlin 1	Mus musculus	26-30
30359906-2	2018	In this report, we present an improved OMRI approach of oxygen measurement using the single line "Finland" trityl spin probe.	Oxygen	56-62	spindlin 1	Mus musculus	114-118
29877075-0	2018	Balancing the Source and Sink of Oxygen Vacancies for the Resistive Switching Memory.	Oxygen	33-39	tribbles pseudokinase 3	Homo sapiens	25-29
30359906-3	2018	Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen.	Oxygen	150-156	spindlin 1	Mus musculus	88-92
16251356-6	2006	Thirty-three of these mutants failed to grow on lipid-supplemented media when combined with a mutation in HEM1, which mimics anaerobic conditions in the presence of oxygen.	Oxygen	165-171	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	106-110
30359906-3	2018	Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen.	Oxygen	150-156	spindlin 1	Mus musculus	133-137
30497437-6	2018	We also found that the mechanisms triggered by ATRA in non-invasive breast tumor cells cultured under hypoxia is in part mediated by PLC-beta2, responsible to counteract the effects of low oxygen availability on CD133 levels.	Oxygen	189-195	phospholipase C beta 2	Homo sapiens	133-142
29911702-3	2018	We use first-principles density functional theory to estimate the self-diffusion coefficient for neutral O0i and doubly ionized Oi2- interstitial oxygen in rutile TiO2 and compare the results to prior isotope diffusion experiments.	Oxygen	146-152	collagen type I alpha 1 chain	Homo sapiens	128-131
17374968-5	2006	RESULTS: The proapoptotic p53 gene was downregulated under a hypoxic (1% O2) condition without exposure to steroid hormones.	Oxygen	73-75	transformation related protein 53, pseudogene	Mus musculus	26-29
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Oxygen	143-145	carbonic anhydrase 2	Homo sapiens	6-10
30425310-3	2018	ME1 expression increases glucose uptake and lactate production, and reduces oxygen consumption, leading to aerobic glycolysis.	Oxygen	76-82	malic enzyme 1	Homo sapiens	0-3
16698969-0	2006	Response of LiF:Mg,Ti to low energy carbon and oxygen ions.	Oxygen	47-53	LIF interleukin 6 family cytokine	Homo sapiens	12-15
30483284-1	2018	The Arabidopsis genome annotation include 11 glyoxalase I (GLXI) genes, all encoding for protein members of the vicinal oxygen chelate (VOC) superfamily.	Oxygen	120-126	glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein	Arabidopsis thaliana	45-57
30483284-1	2018	The Arabidopsis genome annotation include 11 glyoxalase I (GLXI) genes, all encoding for protein members of the vicinal oxygen chelate (VOC) superfamily.	Oxygen	120-126	glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein	Arabidopsis thaliana	59-63
29627385-3	2018	OLE1 expression is tightly regulated to adapt UFA biosynthesis and lipid bilayer properties to changes in temperature, and in UFA or oxygen availability.	Oxygen	133-139	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
29427882-1	2018	In enzymatic fuel cells (EnFCs), hydrogen peroxide formation is one of the main problems when enzymes, such as, glucose oxidase (GOx) is used due to the conversion of oxygen to hydrogen peroxide in the catalytic reaction.	Oxygen	167-173	hydroxyacid oxidase 1	Homo sapiens	112-127
16366623-6	2005	The complexes have an L-shaped structure with a hydrogen bond between the oxygen atom of ketene and the hydrogen atom of HCN or HNC.	Oxygen	74-80	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	121-124
29427882-1	2018	In enzymatic fuel cells (EnFCs), hydrogen peroxide formation is one of the main problems when enzymes, such as, glucose oxidase (GOx) is used due to the conversion of oxygen to hydrogen peroxide in the catalytic reaction.	Oxygen	167-173	hydroxyacid oxidase 1	Homo sapiens	129-132
29315754-11	2018	Increased TSPO expression is an indicator of disrupted metabolic activity and increased reactive oxygen production.	Oxygen	97-103	translocator protein	Homo sapiens	10-14
30369561-6	2018	MCM2-7 gene expression is regulated during cellular aging and the cell cycle, and the expression depends on oxygen concentration.	Oxygen	108-114	minichromosome maintenance complex component 2	Homo sapiens	0-6
16280459-0	2005	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	Oxygen	54-60	neutrophil cytosolic factor 1	Mus musculus	10-17
30539720-0	2018	Oxygen regulation of aquaporin-4 in human placenta.	Oxygen	0-6	aquaporin 4	Homo sapiens	21-32
30539720-3	2018	We analysed AQP4 expression in pre-eclamptic placentae and its regulation by oxygen tension.	Oxygen	77-83	aquaporin 4	Homo sapiens	12-16
30539720-10	2018	In non-pathological explants cultured in hypoxia, AQP4 mRNA and protein were increased compared with placentae cultured in ambient oxygen but decreased after reoxygenation.	Oxygen	131-137	aquaporin 4	Homo sapiens	50-54
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	Oxygen	107-113	S100 calcium binding protein A9	Homo sapiens	38-44
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	Oxygen	107-113	S100 calcium binding protein A9	Homo sapiens	51-57
16370259-0	2005	Cardiovascular neuroregulation during acute exposure to 40, 70, and 100% oxygen at sea level.	Oxygen	73-79	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	83-86
29765012-3	2018	The proposed fluorescence sensing mechanism for detection of glucose is related to the consumption of dissolved oxygen at the double layer of the electrode which is fluorescence quenching agent by glucose-GOx reaction.	Oxygen	112-118	hydroxyacid oxidase 1	Homo sapiens	205-208
30265804-4	2018	The fabricated TGZ@eM nanoreactor can assist the delivery of GOx to tumor cells and then exhaust endogenous glucose and O2 to starve tumors efficiently.	Oxygen	120-122	hydroxyacid oxidase 1	Homo sapiens	61-64
16286658-7	2005	These data suggest a unique mechanism for control of TCR signaling through Hif-1alpha, which may be operative at the physiologic oxygen tensions seen in solid lymphoid organs.	Oxygen	129-135	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	53-56
30219992-6	2018	We proposed that increasing the concentraton of H3O+ resulted in stronger hydrogen bonding between the phosphate oxygens at the water-lipid interface leading to a reduced area per lipid and slightly increased membrane thickness.	Oxygen	113-120	H3 clustered histone 15	Homo sapiens	48-51
30219992-10	2018	Another significant finding was that the hydrogen bonds formed by H3O+ ions with lipid headgroup oxygens are, on average, shorter in length and longer-lived than the ones formed in bulk water.	Oxygen	97-104	H3 clustered histone 15	Homo sapiens	66-69
30219992-11	2018	In addition, the H3O+ ions resided for longer periods in association with the carbonyl oxygens than with either phosphate oxygen in lipids.	Oxygen	87-94	H3 clustered histone 15	Homo sapiens	17-20
30219992-11	2018	In addition, the H3O+ ions resided for longer periods in association with the carbonyl oxygens than with either phosphate oxygen in lipids.	Oxygen	87-93	H3 clustered histone 15	Homo sapiens	17-20
30219992-12	2018	In summary, the MD simulations support a model where the hydrogen bonding capacity of H3O+ for carbonyl and phosphate oxygens is the origin of the pH-induced changes in lipid packing in phospholipid membranes.	Oxygen	118-125	H3 clustered histone 15	Homo sapiens	86-89
29802622-3	2018	For example, oxygen delivery in the peripheral circulatory system is regulated by ATP released from red blood cells and endothelial cells through Panx1 channels.	Oxygen	13-19	pannexin 1	Homo sapiens	146-151
29792731-5	2018	Overexpression of APR3 revealed its mitochondrial localization and induced a robust production of reactive oxygen species that was accompanied by impaired mitochondrial oxygen consumption, complex activity, and lower ATP content, resulting in significant changes in mitochondrial structure, which may contribute to cell apoptosis.	Oxygen	107-113	all-trans retinoic acid induced differentiation factor	Homo sapiens	18-22
29584395-4	2018	We also elucidated that the low O2-dependent PDT of TBP-nMOF in combination with alphaPD-1 checkpoint blockade therapy can not only suppress the growth of primary tumor, but also stimulate an antitumor immune response for inhibiting metastatic tumor growth.	Oxygen	32-34	TATA-box binding protein	Homo sapiens	52-55
29588365-7	2018	In return, the hydrogen atoms contributed by the side chain of Ser-261 and the main chain of Ser-263 bonded the oxygen atoms of CaV1.2 Asp-181.	Oxygen	112-118	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	128-134
29908404-6	2018	Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity.	Oxygen	139-145	oxytocin/neurophysin I prepropeptide	Homo sapiens	118-126
29908404-6	2018	Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity.	Oxygen	258-264	oxytocin/neurophysin I prepropeptide	Homo sapiens	118-126
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Oxygen	89-95	butyrylcholinesterase	Homo sapiens	150-154
29908404-6	2018	Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity.	Oxygen	258-264	oxytocin/neurophysin I prepropeptide	Homo sapiens	448-456
29723894-9	2018	This is because tPA degrades the extracellular matrix, causing vascular stiffness that increases cardiac workload, and thus oxygen requirements.	Oxygen	124-130	chromosome 20 open reading frame 181	Homo sapiens	16-19
29506053-9	2018	The strongest correlations with CPXT parameters were found for miR-208b levels, which had a positive correlation with maximal oxygen uptake (peakVO2) (r = 0.671, P < 0.001), exercise duration (r = 0.445, P = 0.001), and minute ventilation-carbon dioxide production relationship (VE/VCO2) (r = 0.437, P = 0.001) in the HFpEF group.	Oxygen	126-132	microRNA 208b	Homo sapiens	63-71
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Oxygen	89-95	butyrylcholinesterase	Homo sapiens	240-244
29854425-4	2018	Increased Flt3 expression at the protein level was detected in retinas of oxygen-induced retinopathy (OIR) mice at P15 and P18 during retinal NV (RNV) progression.	Oxygen	74-80	FMS-like tyrosine kinase 3	Mus musculus	10-14
30405877-8	2018	Upregulation of MMP1 and downregulation of COL1A1 along with increased DNA damage were also observed under 21% O2 vs 5% O2.	Oxygen	111-113	collagen type I alpha 1 chain	Homo sapiens	43-49
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Oxygen	89-95	butyrylcholinesterase	Homo sapiens	240-244
30405877-8	2018	Upregulation of MMP1 and downregulation of COL1A1 along with increased DNA damage were also observed under 21% O2 vs 5% O2.	Oxygen	120-122	collagen type I alpha 1 chain	Homo sapiens	43-49
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Oxygen	89-95	butyrylcholinesterase	Homo sapiens	240-244
16284587-2	2005	SUMMARY OF BACKGROUND DATA: We have recently shown that in a low oxygen environment, rat nucleus pulposus cells activate phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathways.	Oxygen	65-71	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	156-164
29893810-5	2018	As a consequence, the loss of Merlin in breast cancer resulted in a significant metabolic and bioenergetic adaptation of cells characterized by increased aerobic glycolysis and decreased oxygen consumption.	Oxygen	187-193	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	30-36
30137082-13	2018	Finally, we observed that AFT1-1UP inhibits oxygen consumption through activation of the RNA-binding protein Cth2.	Oxygen	44-50	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	26-30
29538099-10	2018	Notably, preincubated with Spermine, an MCU-specific agonist, or exogenously expressed MCU significantly alleviated cell apoptosis and decreased the reactive oxygen species production in PC12 cells that is induced by MPP treatment.	Oxygen	158-164	mitochondrial calcium uniporter	Rattus norvegicus	87-90
29538099-11	2018	Knockdown of endogenous MCU expression or preincubation with a specific inhibitor of MCU enhances the cell apoptosis and the reactive oxygen species in PC12.	Oxygen	134-140	mitochondrial calcium uniporter	Rattus norvegicus	24-27
29538099-11	2018	Knockdown of endogenous MCU expression or preincubation with a specific inhibitor of MCU enhances the cell apoptosis and the reactive oxygen species in PC12.	Oxygen	134-140	mitochondrial calcium uniporter	Rattus norvegicus	85-88
29480936-0	2018	TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus.	Oxygen	106-112	carbonic anhydrase 3	Rattus norvegicus	141-144
29480936-3	2018	Here, we show that oxygen-glucose deprivation-reperfusion (OGD-RP), an in vitro model that mimic the pathological conditions of the ischemic stroke, increases the phosphorylation level of tropomyosin receptor kinase B (TrkB) in area CA3.	Oxygen	19-25	carbonic anhydrase 3	Rattus norvegicus	233-236
29926980-2	2018	Secondary mesostructured defects in the hierarchical TiO2 microspheres produce oxygen vacancies, which not only significantly enhance photocatalytic activity in the degradation of methylene blue (1.7 times that with P25) and acetone (2.9 times that with P25), but are also beneficial for lithium storage.	Oxygen	79-85	tubulin polymerization promoting protein	Homo sapiens	216-219
29926980-2	2018	Secondary mesostructured defects in the hierarchical TiO2 microspheres produce oxygen vacancies, which not only significantly enhance photocatalytic activity in the degradation of methylene blue (1.7 times that with P25) and acetone (2.9 times that with P25), but are also beneficial for lithium storage.	Oxygen	79-85	tubulin polymerization promoting protein	Homo sapiens	254-257
15935685-3	2005	High-dose erythropoietin (40 IU/ml) profoundly impeded synaptic transmission of rat hippocampal slice cultures when used in conjunction with moderate hypoxia (10% O2 for two 8-h periods).	Oxygen	163-165	erythropoietin	Rattus norvegicus	10-24
29935187-3	2018	Our experimental results had shown that nuclear HIF-1alpha proteins were significantly induced after HepG2 cells treatment with 1% O2 for 6 h and reached the peak expression level in 24 h. Meanwhile, the results of RT-qPCR and Western-blotting showed that HIF-1alpha and cathepsin B (CTSB) expressions increased with a similar pattern in response to hypoxia in the HepG2 cells.	Oxygen	131-133	cathepsin B	Homo sapiens	271-282
29935187-3	2018	Our experimental results had shown that nuclear HIF-1alpha proteins were significantly induced after HepG2 cells treatment with 1% O2 for 6 h and reached the peak expression level in 24 h. Meanwhile, the results of RT-qPCR and Western-blotting showed that HIF-1alpha and cathepsin B (CTSB) expressions increased with a similar pattern in response to hypoxia in the HepG2 cells.	Oxygen	131-133	cathepsin B	Homo sapiens	284-288
29411894-0	2018	Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of HIF-1alpha-VEGF pathway in oxygen-induced retinopathy mice.	Oxygen	119-125	vascular endothelial growth factor A	Mus musculus	103-107
15935685-4	2005	Addition of erythropoietin increased viability of cultured rat embryonic cortical neurons at 21% O2 but decreased viability under hypoxic conditions (2% O2) in a dose-dependent fashion.	Oxygen	97-99	erythropoietin	Rattus norvegicus	12-26
15935685-4	2005	Addition of erythropoietin increased viability of cultured rat embryonic cortical neurons at 21% O2 but decreased viability under hypoxic conditions (2% O2) in a dose-dependent fashion.	Oxygen	153-155	erythropoietin	Rattus norvegicus	12-26
28884388-10	2018	And C3 was associated with AHI, average pulse oxygen saturation (A-spo2), homeostasis model assessment-insulin resistance (HOMA-IR), 2hPG, age, sleep stage (I + II)/TST, and sleep stage (III)/TST, respectively.	Oxygen	46-52	complement C3	Homo sapiens	4-6
15954861-4	2005	The MnSOD/mitochondrial catalase transgenic flies displayed an enhanced resistance to experimental oxidative stress, induced by dietary H2O2 administration or by exposure to 100% ambient oxygen.	Oxygen	187-193	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	4-9
29629463-1	2018	Most biological nitrogen fixation (BNF) results from the activity of the molybdenum nitrogenase (Mo-nitrogenase, Nif), an oxygen-sensitive metalloenzyme complex found in all known diazotrophs.	Oxygen	122-128	S100 calcium binding protein A9	Homo sapiens	113-116
30245966-3	2018	Forced hypoxia-inducible factor 1alpha (HIF-1alpha) expression and physical hypoxia (5% O2) treatment could induce Jagged1 expression in neonatal rat CMs.	Oxygen	88-90	jagged canonical Notch ligand 1	Rattus norvegicus	115-122
29719168-9	2018	In contrast, the Panx1 channel activated to the large channel conformation by extracellular K+, osmotic stress, or low oxygen was inhibited by the multivalent cations in a dose-dependent way.	Oxygen	119-125	pannexin 1	Homo sapiens	17-22
15954861-4	2005	The MnSOD/mitochondrial catalase transgenic flies displayed an enhanced resistance to experimental oxidative stress, induced by dietary H2O2 administration or by exposure to 100% ambient oxygen.	Oxygen	187-193	Catalase	Drosophila melanogaster	24-32
16183497-3	2005	We investigated the effects of this hemoglobin-based oxygen carrier on HO-1 induction and proinflammatory activation of pulmonary endothelium.	Oxygen	53-59	heme oxygenase 1	Homo sapiens	71-75
29932269-8	2018	In both M2c and M2a, severe hypoxic (1%-3% O2 ) exposure significantly suppressed PlGF, Cxcl12, and Mmp2 mRNA, but not Vegfa, compared to normoxia (21% O2 ) or physiological hypoxia (5% O2 ).	Oxygen	43-45	matrix metallopeptidase 2	Mus musculus	100-104
29932269-8	2018	In both M2c and M2a, severe hypoxic (1%-3% O2 ) exposure significantly suppressed PlGF, Cxcl12, and Mmp2 mRNA, but not Vegfa, compared to normoxia (21% O2 ) or physiological hypoxia (5% O2 ).	Oxygen	43-45	vascular endothelial growth factor A	Mus musculus	119-124
29342315-6	2018	The result tallies with the fact that addition of O2 to MAO produces Me2 AlOMe from free Me3 Al which eventually leads to formation of oxidized MAO oligomers and changes in ion abundance.	Oxygen	50-52	malic enzyme 3	Homo sapiens	89-92
29666584-8	2018	Multivariate stepwise regression analysis identified PDE as the strongest independent predictor of whole-body maximal oxygen uptake (VO2max).	Oxygen	118-124	aldehyde dehydrogenase 7 family member A1	Homo sapiens	53-56
16183833-0	2005	The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis.	Oxygen	63-69	C2H2-type zinc finger family protein	Arabidopsis thaliana	24-29
29614836-1	2018	Voltage-gated potassium (Kv) channels, including Kv3.1 and Kv3.4, are known as oxygen sensors, and their function in hypoxia has been well investigated.	Oxygen	79-85	potassium voltage-gated channel subfamily C member 1	Homo sapiens	49-54
29605448-4	2018	This process consumes large amounts of oxygen, which is converted into the highly-reactive superoxide radical O2- and H2O2.	Oxygen	39-45	immunoglobulin kappa variable 1D-39	Homo sapiens	110-122
29864238-3	2018	For H-TiO2 , Ti-H bonds and oxygen vacancies are formed on the surface of H-TiO2 , which results in a more disordered surface lattice.	Oxygen	28-34	relaxin 2	Homo sapiens	74-80
30186264-0	2018	Oxygen Limitation Enhances the Antimicrobial Activity of Fosfomycin in Pseudomonas aeruginosa Following Overexpression of glpT Which Encodes Glycerol-3-Phosphate/Fosfomycin Symporter.	Oxygen	0-6	sn-glycerol-3-phosphate transporter	Pseudomonas aeruginosa PAO1	122-126
29339541-3	2018	Here, we show that the oxygen sensor PHD3 links hypoxic signaling and EMT regulation in the lung tumor microenvironment.	Oxygen	23-29	egl-9 family hypoxia inducible factor 3	Homo sapiens	37-41
29339541-9	2018	Taken together, our results establish a key function for PHD3 in metastasis and drug resistance and suggest opportunities to improve patient treatment by interfering with the feedforward signaling mechanisms activated by PHD3 silencing.Significance: This study links the oxygen sensor PHD3 to metastasis and drug resistance in cancer, with implications for therapeutic improvement by targeting this system.	Oxygen	271-277	egl-9 family hypoxia inducible factor 3	Homo sapiens	57-61
29339541-9	2018	Taken together, our results establish a key function for PHD3 in metastasis and drug resistance and suggest opportunities to improve patient treatment by interfering with the feedforward signaling mechanisms activated by PHD3 silencing.Significance: This study links the oxygen sensor PHD3 to metastasis and drug resistance in cancer, with implications for therapeutic improvement by targeting this system.	Oxygen	271-277	egl-9 family hypoxia inducible factor 3	Homo sapiens	221-225
29339541-9	2018	Taken together, our results establish a key function for PHD3 in metastasis and drug resistance and suggest opportunities to improve patient treatment by interfering with the feedforward signaling mechanisms activated by PHD3 silencing.Significance: This study links the oxygen sensor PHD3 to metastasis and drug resistance in cancer, with implications for therapeutic improvement by targeting this system.	Oxygen	271-277	egl-9 family hypoxia inducible factor 3	Homo sapiens	221-225
16183833-8	2005	Our results suggest that Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis.	Oxygen	64-70	C2H2-type zinc finger family protein	Arabidopsis thaliana	25-30
29803031-4	2018	The results showed that MABR achieved fluxes of 1.62 mg OTC/m2.d and 1117 mg N/m2.d while the fluxes of O2 (JOTC-O2) utilized for OTC and NH4-N (JNH4-N-O2) oxidation were calculated to be 2.94 and 5105 mg O2/m2.d, respectively.	Oxygen	104-106	immunoglobulin kappa variable 1D-39	Homo sapiens	108-115
15936777-8	2005	These reactive oxygen molecules and increased intracellular free calcium may mediate the increase in Jun-AP1 expression and JNK activation induced by G treatment in MC.	Oxygen	15-21	mitogen-activated protein kinase 8	Rattus norvegicus	124-127
30001103-0	2018	Fabrication of Activity-Reporting Glucose Oxidase Nanocapsules with Oxygen-Independent Fluorescence Variation.	Oxygen	68-74	hydroxyacid oxidase 1	Homo sapiens	34-49
29383696-4	2018	RESULTS: TRAP1-depleted A549 cells displayed decreased cell viability likely due to impaired mitochondrial function including decreased ATP/AMP ratio, oxygen consumption and membrane potential, as well as increased apoptotic indicators.	Oxygen	151-157	TNF receptor associated protein 1	Homo sapiens	9-14
16210801-6	2005	Hypoxia (7% O2) induced low oxygen tension in proximal tubular epithelial cells of renal cortex, and increased the expression of EPO mRNA and the number of EPO-producing cells in both ICR and ICGN mice.	Oxygen	12-14	erythropoietin	Mus musculus	129-132
29452237-5	2018	A significant increase of cytoplasmic O2- production was observed after 1 and 4 h incubation of chlordecone, but not after 2 h. The NADPH oxidase inhibitor apocynin or silencing p47phox prevented angiogenesis and tube formation but also the increase in production of O2- at 1 h. In addition, apocynin as well silencing p47phox prevented eNOS activation and the NO synthase inhibitor L-NAME inhibited mitochondrial O2-production.	Oxygen	38-40	neutrophil cytosolic factor 1	Homo sapiens	178-185
29452237-5	2018	A significant increase of cytoplasmic O2- production was observed after 1 and 4 h incubation of chlordecone, but not after 2 h. The NADPH oxidase inhibitor apocynin or silencing p47phox prevented angiogenesis and tube formation but also the increase in production of O2- at 1 h. In addition, apocynin as well silencing p47phox prevented eNOS activation and the NO synthase inhibitor L-NAME inhibited mitochondrial O2-production.	Oxygen	38-40	neutrophil cytosolic factor 1	Homo sapiens	319-326
29452237-5	2018	A significant increase of cytoplasmic O2- production was observed after 1 and 4 h incubation of chlordecone, but not after 2 h. The NADPH oxidase inhibitor apocynin or silencing p47phox prevented angiogenesis and tube formation but also the increase in production of O2- at 1 h. In addition, apocynin as well silencing p47phox prevented eNOS activation and the NO synthase inhibitor L-NAME inhibited mitochondrial O2-production.	Oxygen	267-269	neutrophil cytosolic factor 1	Homo sapiens	178-185
29452237-5	2018	A significant increase of cytoplasmic O2- production was observed after 1 and 4 h incubation of chlordecone, but not after 2 h. The NADPH oxidase inhibitor apocynin or silencing p47phox prevented angiogenesis and tube formation but also the increase in production of O2- at 1 h. In addition, apocynin as well silencing p47phox prevented eNOS activation and the NO synthase inhibitor L-NAME inhibited mitochondrial O2-production.	Oxygen	267-269	neutrophil cytosolic factor 1	Homo sapiens	178-185
30001103-6	2018	The peripheral polymer shell confines the orientation of GOx and prevents it from denaturing, whereas incorporated DAA-flavin can replace the oxygen as an alternative electron acceptor to interact with the active centers of GOx in the presence of the substrate, thus giving the nanocapsules oxygen-independent characteristics.	Oxygen	142-148	hydroxyacid oxidase 1	Homo sapiens	224-227
30001103-6	2018	The peripheral polymer shell confines the orientation of GOx and prevents it from denaturing, whereas incorporated DAA-flavin can replace the oxygen as an alternative electron acceptor to interact with the active centers of GOx in the presence of the substrate, thus giving the nanocapsules oxygen-independent characteristics.	Oxygen	291-297	hydroxyacid oxidase 1	Homo sapiens	224-227
30123074-6	2018	Knockdown of TIMMDC1 significantly and exclusively reduced the activity of mitochondrial complex I but not complex II~ IV, and caused an obvious inhibition in mitochondrial respiration and ATP-linked oxygen consumption.	Oxygen	200-206	translocase of inner mitochondrial membrane domain containing 1	Homo sapiens	13-20
16210801-6	2005	Hypoxia (7% O2) induced low oxygen tension in proximal tubular epithelial cells of renal cortex, and increased the expression of EPO mRNA and the number of EPO-producing cells in both ICR and ICGN mice.	Oxygen	12-14	erythropoietin	Mus musculus	156-159
29106077-5	2018	Further, the presence of oxygen increased the interaction of selenoxides with the delta-ALAD active site by O...Zn coordination.	Oxygen	25-31	aminolevulinate dehydratase	Homo sapiens	82-92
16212539-5	2005	The data presented suggest that the regulation of mononuclear phagocytes by leptin is associated with activation of the JAK/STAT signaling pathway, which leads to stimulation of phagocytosis, production of oxygen and nitrogen reactive species, and also to increase in secretion of pro-inflammatory cytokines.	Oxygen	206-212	leptin	Homo sapiens	76-82
29714400-4	2018	When this bifunctional catalyst was further used for H2 and O2 production in an electrochemical water-splitting unit, it can operate in ambient conditions with a competitive gas production rate of 1.15 and 0.57 muL s-1 for hydrogen and oxygen, respectively, showing its potential for practical applications.	Oxygen	236-242	relaxin 2	Homo sapiens	53-62
29732664-0	2018	Oxygen-Doped Zig-Zag Molecular Ribbons.	Oxygen	0-6	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	17-20
29732664-1	2018	The synthesis of a zig-zag oxygen-doped molecular rhombic ribbon has been achieved.	Oxygen	27-33	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	23-26
29980690-8	2018	Our data underscores the important modulatory role of oxygen tension on the chondrocyte"s responsiveness to TGF-beta3 and/or BMP7.	Oxygen	54-60	bone morphogenetic protein 7	Homo sapiens	125-129
29406374-2	2018	The aim of this study was to determine the impact of RBC transfusion on cerebral oxygen metabolism in noncardiac and cardiac postsurgical infants.	Oxygen	81-87	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	53-56
29406374-15	2018	CONCLUSION: Following RBC transfusion, cerebral oxygen saturation increases and cerebral fractional tissue oxygen extraction decreases.	Oxygen	48-54	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	22-25
29406374-15	2018	CONCLUSION: Following RBC transfusion, cerebral oxygen saturation increases and cerebral fractional tissue oxygen extraction decreases.	Oxygen	107-113	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	22-25
29468873-3	2018	H2O and O3 were adopted as the oxygen sources of the SrO subcycles, whereas only O3 was used for the TiO2 ALD subcycles.	Oxygen	31-37	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-10
16036365-5	2005	The analysis of H2O2 formation upon oxidation of DOPA by O2*- using 1-hydroxy-3-carboxy-pyrrolidine (CP-H), and SOD as competitive reagents for superoxide provides consistent values of the rate constant for the reaction between DOPA and O2*- being equal to (3.4+/-0.6)x10(5) M(-1) s(-1).	Oxygen	18-20	carboxypeptidase E	Homo sapiens	101-105
29856211-1	2018	Electron spin resonance (ESR) is a powerful analytical technique used for the detection, quantification, and characterization of paramagnetic species ranging from stable organic free radicals and defects in crystals to gaseous oxygen.	Oxygen	227-233	spindlin 1	Homo sapiens	9-13
15993946-6	2005	In the systems with 3,3,3-tet, the MLL" type species are formed in which the oxygen atoms of the phosphate group and nitrogen atoms of the polyamine are involved in metallation, whereas the N3 atom from the pyrimidine ring of the nucleotide is located outside the inner coordination sphere of copper ion.	Oxygen	77-83	lysine methyltransferase 2A	Homo sapiens	35-38
30047477-4	2018	RESULTS: We found that higher endogenous oxytocin levels are associated with reduced central amygdala volume and blood oxygen level-dependent activity in response to aversive stimuli.	Oxygen	119-125	oxytocin/neurophysin I prepropeptide	Homo sapiens	41-49
29670693-5	2018	Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O2- ).	Oxygen	118-124	thioredoxin reductase 1	Homo sapiens	14-20
29670693-5	2018	Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O2- ).	Oxygen	118-124	thioredoxin reductase 1	Homo sapiens	64-70
29670693-5	2018	Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O2- ).	Oxygen	154-156	thioredoxin reductase 1	Homo sapiens	14-20
29670693-5	2018	Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O2- ).	Oxygen	154-156	thioredoxin reductase 1	Homo sapiens	64-70
16028905-2	2005	Introduction of fused benzene and pyrazine rings to the TTF skeleton was effective to enhance the intermolecular interactions and stability to oxygen.	Oxygen	143-149	ras homolog family member H	Homo sapiens	56-59
29167125-5	2018	Exposure of rat primary AECs to hypoxia (1.5% O2 for 24 h) resulted in hypoxia-inducible factor (HIF)-1alpha protein stabilization, partly dependent on reactive oxygen species (ROS) accumulation, and in a twofold increase in AEC apoptosis that was prevented by the HIF inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl-indazole and the antioxidant drug N-acetyl cysteine.	Oxygen	46-48	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	71-108
28915219-11	2018	In the control receiving intratracheal oxygen pO2 decreased from 324 to 88 mmHg after 16 minu of CPR.	Oxygen	39-45	cytochrome p450 oxidoreductase	Sus scrofa	97-100
15970707-1	2005	Under low oxygen tension, the activated transcription factor HIF-1alpha upregulates an array of hypoxia-inducible genes via heterodimerization with ARNT and binding to the hypoxia-responsive element in the promoter.	Oxygen	10-16	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	148-152
29959116-5	2018	Like beta-globin, gamma-globin also has oxygen-carrying capabilities.	Oxygen	40-46	hemoglobin subunit gamma 1	Homo sapiens	18-30
29735733-3	2018	In apo-GroEL, the nucleotide-binding sites of different rings are connected to one another by the interaction of the e-amino group of lysine 105 of one helix D across the twofold axis with the negatively charged carbonyl oxygen atom of alanine 109 at the C-terminus of the other helix D. Upon binding ATP, the K105-A109 salt bridge breaks and both helices move apart by approximately 3.5 A en bloc toward the ATP.	Oxygen	221-227	heat shock protein family D (Hsp60) member 1	Homo sapiens	7-12
29335339-5	2018	In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions.	Oxygen	140-146	utrophin	Homo sapiens	35-39
29335339-5	2018	In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions.	Oxygen	140-146	fission, mitochondrial 1	Homo sapiens	40-44
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	269-276	butyrylcholinesterase	Homo sapiens	64-85
29130578-8	2018	Notably, mitochondrially targeted p53 (mito-p53) directly reduced mitochondria DNA-encoded ND2 and ND4 gene expression resulting in increased reactive oxygen species (ROS) and reduced mitochondrial oxygen consumption.	Oxygen	151-157	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	91-94
29174352-2	2018	In general, a higher oxygen supply is beneficial for cell growth but obstructs PUFA synthesis.	Oxygen	21-27	pumilio RNA binding family member 3	Homo sapiens	79-83
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	KIT ligand	Homo sapiens	144-160
29895317-8	2018	The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence.	Oxygen	24-26	KIT ligand	Homo sapiens	162-165
29895328-5	2018	Indeed, we demonstrate that REDD1 is required to decrease O2 and ATP consumption in skeletal muscle via reduction of the extent of mitochondrial-associated endoplasmic reticulum membranes (MAMs), a central hub connecting energy production by mitochondria and anabolic processes.	Oxygen	58-60	DNA damage inducible transcript 4	Homo sapiens	28-33
29174352-5	2018	In this review, the effects of oxygen on the PUFA synthesis, sources of oxidative damage, and anti-oxidative defense systems of microalgae were summarized and discussed.	Oxygen	31-37	pumilio RNA binding family member 3	Homo sapiens	45-49
29185100-0	2018	Spatial distribution of CD115+ and CD11b+ cells and their temporal activation during oxygen-induced retinopathy in mice.	Oxygen	85-91	integrin subunit alpha M	Homo sapiens	35-40
29872089-8	2018	Cortical hypoxia was observed in the stenotic kidney of Ccl2 KO mice, as assessed by blood oxygen level-dependent MRI (BOLD-MRI).	Oxygen	91-97	chemokine (C-C motif) ligand 2	Mus musculus	56-60
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	269-276	carboxyl ester lipase	Homo sapiens	141-161
29301980-4	2018	Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia-inducible factor 1A (HIF1A), miR-210 and EDN2 Hypoxia-induced miR-210 was suppressed in HIF1A-silenced SVOG cells, suggesting that miR-210 is HIF1A dependent.	Oxygen	47-49	endothelin 2	Homo sapiens	109-113
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	348-355	butyrylcholinesterase	Homo sapiens	64-85
16022504-9	2005	Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase.	Oxygen	348-355	carboxyl ester lipase	Homo sapiens	141-161
29549726-6	2018	CCl4 led to oxidative stress, supported by the reduced superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as enhanced malondialdehyde (MDA) and O2- levels in liver samples.	Oxygen	167-169	chemokine (C-C motif) ligand 4	Mus musculus	0-4
15901768-4	2005	Cytochrome P450 system is crucial to the generation of reactive oxygen metabolites and is present at high concentration in the ER.	Oxygen	64-70	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	0-15
29339137-6	2018	Similarly, exposure of in vitro produced bovine embryos to atmospheric oxygen concentrations was associated with disruptions in the transcriptional regulation of TET1, TET3, and DNMT3a, along with the DNA methyltransferase co-factor HELLS.	Oxygen	71-77	DNA methyltransferase 3 alpha	Bos taurus	178-184
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	161-165
29339137-7	2018	In addition, exposure to high oxygen was associated with alterations in the abundance of transcripts encoding members of the Polycomb repressor complex (EED and EZH2), the histone methyltransferase SETDB1 and multiple histone demethylases (KDM1A, KDM4B, and KDM4C).	Oxygen	30-36	lysine (K)-specific demethylase 4B	Mus musculus	247-252
29242152-0	2018	Human umbilical cord-derived mesenchymal stem cells protect from hyperoxic lung injury by ameliorating aberrant elastin remodeling in the lung of O2-exposed newborn rat.	Oxygen	146-148	elastin	Rattus norvegicus	112-119
29242152-5	2018	This study demonstrated that UC-MSCs reduce elastin expression stimulated by 90% O2 in human lung fibroblasts-a (HLF-a), and inhibit HLF-a transdifferentiation into myofibroblasts.	Oxygen	81-83	elastin	Homo sapiens	44-51
16852428-5	2005	A lanthanum acid site in the pair initiates the split by interacting with one of the chlorine atoms in CCl4, and an oxygen base site stabilizes the remaining CCl3 fragment.	Oxygen	116-122	C-C motif chemokine ligand 3	Homo sapiens	158-162
29343030-9	2018	Conclusion: HMGB1 mRNA expression levels increase at 2, 4 h, decrease at 6 h in the Sombati"s cell model in normal oxygen culture, while increase at 6, 8 h, and decrease at 10 h in LI-PILO induced rat model with SE; the NR2B mRNA relative expression increases with time in both the Sombati"s cell model in normal oxygen culture and rat model of SE.	Oxygen	115-121	high mobility group box 1	Rattus norvegicus	12-17
29343030-9	2018	Conclusion: HMGB1 mRNA expression levels increase at 2, 4 h, decrease at 6 h in the Sombati"s cell model in normal oxygen culture, while increase at 6, 8 h, and decrease at 10 h in LI-PILO induced rat model with SE; the NR2B mRNA relative expression increases with time in both the Sombati"s cell model in normal oxygen culture and rat model of SE.	Oxygen	313-319	high mobility group box 1	Rattus norvegicus	12-17
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	105-108
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	367-370
15879308-6	2005	Hypoxia (1% O2, 24 hours) stimulated HIF1alpha activity by 5.1+/-0.6 fold.	Oxygen	12-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-46
29325421-5	2018	The post-CPAP group had fewer resuscitations, required fewer surfactant doses, spent fewer days on mechanical ventilation, and demonstrated less of a need for fraction of inspired oxygen &gt; 30%.	Oxygen	180-186	centromere protein J	Homo sapiens	9-13
29334122-3	2018	It is known that oxygen and glucose deprivation (OGD) can induce necroptosis, which is regulated by RIP3 in neurons.	Oxygen	17-23	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	100-104
31149234-10	2018	Average oxygen saturation (AvO2) and the lowest oxygen saturation were negatively correlated with Lp-PLA2.	Oxygen	8-14	phospholipase A2 group VII	Homo sapiens	98-105
29030974-5	2018	Employing regression models, we examined effects of SLC6A3 methylation on nucleus accumbens (NAc) blood-oxygen-level dependent (BOLD) responses during anticipation of high/low reward/loss.	Oxygen	104-110	solute carrier family 6 member 3	Homo sapiens	52-58
29618249-10	2018	The magnetic behavior of La1 -xCa xFeO3 tilts towards G-type antiferromagnetism; the magnetic orientation is achieved from the super exchange interaction of Fe3+ ions with oxygen ions.	Oxygen	172-178	X chromosome controlling element	Homo sapiens	30-33
28345492-2	2018	The drug has oxidizing potential and as an adverse effect, it can convert the ferrous form of iron in erythrocytes to its ferric form resulting in the formation of methemoglobin which makes the heme component incapable of carrying oxygen.	Oxygen	231-237	hemoglobin subunit gamma 2	Homo sapiens	164-177
16061022-9	2005	CONCLUSION: The sarcolemmal GLUT4 content in the type 2 diabetic myocardium is obviously decreased, which may be associated with the decrease of glucose uptake and increase of fatty acid oxygen.	Oxygen	187-193	solute carrier family 2 member 4	Rattus norvegicus	28-33
30079190-0	2018	Modulating the oxygen reduction activity of heteroatom-doped carbon catalysts via the triple effect: charge, spin density and ligand effect.	Oxygen	15-21	spindlin 1	Homo sapiens	109-113
29584395-2	2018	It was found that TBP-MOF exhibited red-shifted absorption bands and strong near-infrared luminescence for bioimaging, whereas the pi-extended benzoporphyrin-based linkers of TBP-MOF facilitated 1O2 generation to enhance O2-dependent photodynamic therapy (PDT).	Oxygen	196-198	TATA-box binding protein	Homo sapiens	175-178
29762540-1	2018	BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators" (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance.	Oxygen	207-213	peroxisome proliferator activated receptor delta	Homo sapiens	75-80
29696063-2	2018	This study aimed to investigate the response of ICAM-1to exhaustive submaximal exercise and its correlation with maximal oxygen consumption (VO2max), body mass index (BMI), waist-hip ratio (WHR), body fat percentage (BF %) and calories burned during exercise (CB) in healthy men.	Oxygen	121-127	intercellular adhesion molecule 1	Homo sapiens	48-54
29115559-5	2018	Expression levels of SUMO1 and SUMO2/3 proteins in the normoxia group were significantly lower than those in the medium- or high-oxygen groups (P&lt;0.01), but were comparable to those in the low-oxygen group.	Oxygen	129-135	small ubiquitin like modifier 2	Homo sapiens	31-36
29115559-5	2018	Expression levels of SUMO1 and SUMO2/3 proteins in the normoxia group were significantly lower than those in the medium- or high-oxygen groups (P&lt;0.01), but were comparable to those in the low-oxygen group.	Oxygen	196-202	small ubiquitin like modifier 2	Homo sapiens	31-36
29115559-6	2018	SIRT1 expression levels in both the medium- and high-oxygen groups were significantly lower than those in the normoxia group (P&lt;0.01).	Oxygen	53-59	sirtuin 1	Homo sapiens	0-5
29115559-8	2018	Supplemental oxygen with FiO2&gt;=30% was associated with upregulation of SUMO1 and SUMO2/3 expression and downregulation of SIRT1 expression.	Oxygen	13-19	small ubiquitin like modifier 2	Homo sapiens	84-89
15933023-0	2005	The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells.	Oxygen	67-73	HtrA serine peptidase 1	Homo sapiens	4-8
29115559-8	2018	Supplemental oxygen with FiO2&gt;=30% was associated with upregulation of SUMO1 and SUMO2/3 expression and downregulation of SIRT1 expression.	Oxygen	13-19	sirtuin 1	Homo sapiens	125-130
29633614-2	2018	Upon the specific uptake of MG/HA by CD44 overexpressed cancer cells, GOD catalyzed the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2) accompanying the consumption of oxygen (O2).	Oxygen	189-195	CD44 molecule (Indian blood group)	Homo sapiens	37-41
29633614-2	2018	Upon the specific uptake of MG/HA by CD44 overexpressed cancer cells, GOD catalyzed the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2) accompanying the consumption of oxygen (O2).	Oxygen	153-155	CD44 molecule (Indian blood group)	Homo sapiens	37-41
29210387-3	2017	The results show that H3O+ accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the phosphate and carbonyl oxygens in phospholipids.	Oxygen	167-174	H3 clustered histone 15	Homo sapiens	22-25
15984780-8	2005	The strong ligands that remained in the oxygen-oxidized samples were resistant to further oxidation by chlorine, indicating that oxidation of S(-II) results in the formation of other sulfur-containing ligands such as S8 that form strong complexes with Hg(II).	Oxygen	40-46	transcription elongation factor A1	Homo sapiens	142-147
29569283-6	2018	This device shows excellent durability and specific selectivity toward the oxygen evolution reaction in seawater with near 100% Faradaic efficiency for the production of H2 and O2 .	Oxygen	75-81	relaxin 2	Homo sapiens	170-179
15778089-9	2005	These data suggest that amplification of c-myb in tumor cells may lead to robust GRP78 gene induction, which may in turn assist cells in survival under conditions of oxygen deprivation and nutrient stress.	Oxygen	166-172	MYB proto-oncogene, transcription factor	Homo sapiens	41-46
28971989-11	2018	In conclusion, mTOR inhibition induces mitochondrial dysfunction leading to decreased oxygen availability in normal and diabetic kidneys, which translates into increased KIM-1 in the urine.	Oxygen	86-92	hepatitis A virus cellular receptor 1	Homo sapiens	170-175
29594588-0	2017	Glucose oxidase assisted visual detection of glucose using oxygen deficient alpha-MoO3-x nanoflakes.	Oxygen	59-65	hydroxyacid oxidase 1	Homo sapiens	0-15
16180749-2	2005	The results showed that when the concentration of SO2 was 10 and 40 microl x L(-1), the O2*- content and peroxidase (POD) and catalase(CAT) activities of wheat leaf were increased, while the activity of superoxide dismutase(SOD) was reduced.	Oxygen	51-53	peroxidase-like	Triticum aestivum	105-115
29235464-6	2017	SYK inhibition in vivo represses beta-agonist-induced thermogenesis and oxygen consumption.	Oxygen	72-78	spleen tyrosine kinase	Mus musculus	0-3
29791234-1	2018	Sedimentological observations from the Paleoproterozoic Huronian Supergroup are suggested to mark the rise in atmospheric oxygen at that time, which is commonly known as the Great Oxidation Event (GOE) and typically coupled with a transition from mass-independent fractionation (MIF) to mass-dependent fractionation (MDF) of sulfur isotopes.	Oxygen	122-128	macrophage migration inhibitory factor	Mandrillus leucophaeus	279-282
16180749-2	2005	The results showed that when the concentration of SO2 was 10 and 40 microl x L(-1), the O2*- content and peroxidase (POD) and catalase(CAT) activities of wheat leaf were increased, while the activity of superoxide dismutase(SOD) was reduced.	Oxygen	51-53	peroxidase-like	Triticum aestivum	117-120
29058366-4	2017	Using nuclear magnetic resonance, operando electrochemical pressure measurements, and mass spectrometry, it is shown that on discharging LiOH forms via a 4 e- oxygen reduction reaction, the H in LiOH coming solely from added H2 O and the O from both O2 and H2 O.	Oxygen	159-165	immunoglobulin kappa variable 1D-39	Homo sapiens	250-261
16180749-2	2005	The results showed that when the concentration of SO2 was 10 and 40 microl x L(-1), the O2*- content and peroxidase (POD) and catalase(CAT) activities of wheat leaf were increased, while the activity of superoxide dismutase(SOD) was reduced.	Oxygen	51-53	catalase-1	Triticum aestivum	135-138
29518608-5	2018	Additionally, RIP3-deletion reduced malondialdehyde (MDA), H2O2 and O2-, whereas enhanced superoxide dismutase (SOD), GSH and GSH-Px levels in potassium oxonate-induced mice.	Oxygen	61-63	receptor-interacting serine-threonine kinase 3	Mus musculus	14-18
29273673-0	2018	Reduced SERCA activity underlies dysregulation of Ca2+ homeostasis under atmospheric O2 levels.	Oxygen	85-87	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	8-13
29273673-4	2018	Agonist-stimulated phosphorylation of the SERCA regulatory protein phospholamban was increased in cells cultured under 5% O2.	Oxygen	122-124	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	42-47
29371964-3	2017	FIH1 protein abundance and spatial distribution in the developing placenta directly correlated with oxygen tension in vivo.	Oxygen	100-106	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	0-4
29371964-10	2017	We propose a novel mode of regulation of FIH1 stability by dynamic SUMOylation and deSUMOylation in the human placenta in response to changing oxygen tension, thereby mediating HIF1A transcriptional activity in physiological and pathological conditions.	Oxygen	143-149	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	41-45
29211771-3	2017	Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase).	Oxygen	75-81	ataxin 1	Mus musculus	166-174
29211771-3	2017	Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis and oxygen consumption assays, we report that in the presence of mutant polyglutamine-expanded ataxin-1, SCA1 mice display deficits in cerebellar OXPHOS complex I (NADH-coenzyme Q oxidoreductase).	Oxygen	75-81	ataxin 1	Mus musculus	176-180
29206844-5	2017	Since epigenetic silencing of the prolyl-hydroxylase-domain-3 (PHD3) enzyme responsible for the O2-dependent regulation of HIF2alpha is frequently observed in MM tumors, we asked if PHD3 plays a role in regulating sensitivity to hypoxia.	Oxygen	96-98	egl-9 family hypoxia inducible factor 3	Homo sapiens	34-61
29546279-0	2018	Letter to the Editor: "Placental HtrA3 Is Regulated by Oxygen Tension and Serum Levels Are Altered During Early Pregnancy in Women Destined to Develop Preeclampsia".	Oxygen	55-61	HtrA serine peptidase 3	Homo sapiens	33-38
29206844-5	2017	Since epigenetic silencing of the prolyl-hydroxylase-domain-3 (PHD3) enzyme responsible for the O2-dependent regulation of HIF2alpha is frequently observed in MM tumors, we asked if PHD3 plays a role in regulating sensitivity to hypoxia.	Oxygen	96-98	egl-9 family hypoxia inducible factor 3	Homo sapiens	63-67
15637113-4	2005	The aims of this study were to determine whether central subchronic infusion of ANG II in normal animals has effects on O2- production and expression of NAD(P)H oxidase subunits as well as ANG II type 1 (AT1) receptors in the rostral ventrolateral medulla (RVLM).	Oxygen	120-122	angiogenin	Oryctolagus cuniculus	80-83
29206844-6	2017	We found that restoring PHD3 expression using a lentivirus vector or overcoming PHD3 epigenetic silencing using a demethyltransferase inhibitor, 5-Aza-2"-deoxycytidine (5-Aza-dC), rescued O2-dependent regulation of HIF2alpha and restored sensitivity of MM cells to hypoxia-mediated apoptosis.	Oxygen	188-190	egl-9 family hypoxia inducible factor 3	Homo sapiens	80-84
29206844-7	2017	This provides a rationale for targeting the PHD3-mediated regulation of the adaptive cellular hypoxic response in MM and suggests that targeting the O2-sensing pathway, alone or in combination with other anti-myeloma chemotherapeutics, may have clinical efficacy.	Oxygen	149-151	egl-9 family hypoxia inducible factor 3	Homo sapiens	44-48
28420272-4	2018	RESULTS: In infants that received O2 at birth, ROS and MDA levels, and SIRT1 translocation rates gradually increased in a concentration-dependent manner, while SIRT1 gradually decreased.	Oxygen	34-36	sirtuin 1	Homo sapiens	71-76
28420272-4	2018	RESULTS: In infants that received O2 at birth, ROS and MDA levels, and SIRT1 translocation rates gradually increased in a concentration-dependent manner, while SIRT1 gradually decreased.	Oxygen	34-36	sirtuin 1	Homo sapiens	160-165
15828054-6	2005	Patients with HPS had a mean partial pressure of arterial oxygen (PaO(2)) decline of 5.2 + 2.3 mm Hg per year awaiting OLT.	Oxygen	58-64	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	14-17
29850636-2	2018	Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1beta, IL-10, and IL-8 and TNF-alpha in preterm newborns under mechanical ventilation (MV) in their first two days.	Oxygen	57-63	interleukin 10	Homo sapiens	143-148
28058534-0	2017	Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.	Oxygen	11-17	Wnt family member 10A	Rattus norvegicus	107-114
28686305-5	2017	The number of oxygen atoms segregating in a unit TB area NGB (in atoms nm-2 ) was determined to be proportional to both the number of the atomic sites under tensile stress in a unit TB area nbc and the average concentration of oxygen atoms around the TB [Oi ] (in at.%) with NGB ~ 50 nbc [Oi ].	Oxygen	14-20	neuroglobin	Homo sapiens	57-60
28686305-5	2017	The number of oxygen atoms segregating in a unit TB area NGB (in atoms nm-2 ) was determined to be proportional to both the number of the atomic sites under tensile stress in a unit TB area nbc and the average concentration of oxygen atoms around the TB [Oi ] (in at.%) with NGB ~ 50 nbc [Oi ].	Oxygen	14-20	neuroglobin	Homo sapiens	275-278
29523748-0	2018	High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2.	Oxygen	77-83	scavenger receptor class B member 1	Homo sapiens	116-121
28686305-5	2017	The number of oxygen atoms segregating in a unit TB area NGB (in atoms nm-2 ) was determined to be proportional to both the number of the atomic sites under tensile stress in a unit TB area nbc and the average concentration of oxygen atoms around the TB [Oi ] (in at.%) with NGB ~ 50 nbc [Oi ].	Oxygen	227-233	neuroglobin	Homo sapiens	57-60
16176069-0	2005	Endoplasmic reticulum dysfunction and Ca2+ deregulation in isolated CA1 neurons during oxygen and glucose deprivation.	Oxygen	87-93	carbonic anhydrase 1	Rattus norvegicus	68-71
29153134-3	2017	demonstrate that deletion of prolyl hydroxylase 2 and 3, 2 of the major oxygen sensors, in the FoxD1 lineage cells reduces kidney size and inhibits nephrogenesis in mice.	Oxygen	72-78	forkhead box D1	Mus musculus	95-100
29438799-4	2018	MTT assay showed that lig4-4 significantly enhanced cell viability of cultured neurons under the condition of oxygen and glucose deprivation followed by reoxygenation (OGD/R).	Oxygen	110-116	DNA ligase 4	Rattus norvegicus	22-28
16176069-2	2005	The aim of the present study was to investigate the routes of Ca2+ entry during non-excitotoxic oxygen and glucose deprivation (OGD) in acutely dissociated rat CA1 neurons.	Oxygen	96-102	carbonic anhydrase 1	Rattus norvegicus	160-163
29615703-5	2018	Subsequent experiments revealed that hypoxic conditions (1% O2) stimulate endogenous and exogenous (transfected Ad-Foxn1) Foxn1 expression in cultured keratinocytes.	Oxygen	60-62	forkhead box N1	Mus musculus	115-120
15626745-2	2005	Erythropoietin gene expression increases under conditions associated with lowered oxygen content such as anemia and hypoxia.	Oxygen	82-88	erythropoietin	Mus musculus	0-14
29615703-5	2018	Subsequent experiments revealed that hypoxic conditions (1% O2) stimulate endogenous and exogenous (transfected Ad-Foxn1) Foxn1 expression in cultured keratinocytes.	Oxygen	60-62	forkhead box N1	Mus musculus	122-127
29351410-9	2018	The basal protein expression levels of STIM1/2, Orai1/2, and TRPC6 were higher in CASMC than in PASMC, but hypoxia (3% O2 for 72 h) significantly upregulated protein expression levels of STIM1/STIM2, Orai1/Orai2, and TRPC6 and increased the resting [Ca2+]cyt only in PASMC, but not in CASMC.	Oxygen	119-121	stromal interaction molecule 2	Homo sapiens	193-198
29351410-9	2018	The basal protein expression levels of STIM1/2, Orai1/2, and TRPC6 were higher in CASMC than in PASMC, but hypoxia (3% O2 for 72 h) significantly upregulated protein expression levels of STIM1/STIM2, Orai1/Orai2, and TRPC6 and increased the resting [Ca2+]cyt only in PASMC, but not in CASMC.	Oxygen	119-121	ORAI calcium release-activated calcium modulator 2	Homo sapiens	206-211
28943321-10	2018	CONCLUSIONS: Although using low oxygen flow significantly shortens CPAP weaning time, it may increase risks of BPD and ROP, both known to be related to oxygen toxicity.	Oxygen	32-38	centromere protein J	Homo sapiens	67-71
28819713-5	2017	Elevated plasma GDF-15 levels were positively related to Functional Class, uric acid, N-terminal pro-B-type natriuretic peptide (NT-proBNP), pulmonary artery systolic pressure, mean pulmonary artery pressure, pulmonary blood flow/systemic blood flow and pulmonary vascular resistance, and a lower mixed venous oxygen saturation (Svo2).	Oxygen	310-316	growth differentiation factor 15	Homo sapiens	16-22
29110468-5	2017	This specific redox-triggered BIE is capable of quantitatively detecting dissolved oxygen in aqueous solution in a light-up manner, and trace amount of dissolved oxygen at ppb level is achieved based on this detection method.	Oxygen	83-89	histatin 1	Homo sapiens	172-175
29110468-5	2017	This specific redox-triggered BIE is capable of quantitatively detecting dissolved oxygen in aqueous solution in a light-up manner, and trace amount of dissolved oxygen at ppb level is achieved based on this detection method.	Oxygen	162-168	histatin 1	Homo sapiens	172-175
29167529-5	2017	RORalpha enhanced oxygen consumption rate and expression of genes associated with mitochondrial quality control.	Oxygen	18-24	RAR related orphan receptor A	Homo sapiens	0-8
29570658-4	2018	Depending on the adsorption methods of Hg0 and HgO, three reaction pathways (pathways I, II, and III) of Hg0 oxidation by oxygen are proposed.	Oxygen	122-128	homogentisate 1,2-dioxygenase	Homo sapiens	39-50
15857276-10	2005	There was a 2.4-fold induction in preretinal HIF1alpha expression in oxygen-reared animals when compared to room-air-reared animals.	Oxygen	69-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-54
28971668-4	2017	Species of O2 - were identified as primary radicals that triggered the spin-transfer from the triplet state of O2 to the aminobenzene ring of luminol by the aids of Au NCs, leading to an efficient phosphorescence.	Oxygen	11-13	spindlin 1	Homo sapiens	71-75
15803054-2	2005	We found that 4 h of mild hypoxia (5% O2) caused substantial necrosis of isolated rat aortae (measured as lactate dehydrogenase release) if inducible NO synthase (iNOS) had previously been induced by endotoxin plus interferon-gamma.	Oxygen	38-40	interferon gamma	Rattus norvegicus	215-231
28971668-4	2017	Species of O2 - were identified as primary radicals that triggered the spin-transfer from the triplet state of O2 to the aminobenzene ring of luminol by the aids of Au NCs, leading to an efficient phosphorescence.	Oxygen	111-113	spindlin 1	Homo sapiens	71-75
29600246-6	2018	Average and initial oxygen consumption rates (OCR) were positively correlated to VRF/mA (vanilline reactive flavans/monomeric anthocyanins) and T/A ratios while OCRs were negatively related to the wine content in monomeric and total anthocyanins.	Oxygen	20-26	vascular endothelial growth factor B	Homo sapiens	81-84
15722187-2	2005	Within a few minutes, a cable car facilitates an ascent from 1702 to 2700 m above sea level, where the partial pressure of oxygen is about 550 mmHg (as compared to 760 mmHg at sea level).	Oxygen	123-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	82-85
28930449-1	2018	Catalytic four-electron reduction of O2 to water is one of the most extensively studied electrochemical reactions due to O2 exceptional availability and high O2/H2O redox potential, which may in particular allow highly energetic reactions in fuel cells.	Oxygen	37-39	immunoglobulin kappa variable 1D-39	Homo sapiens	158-164
28634060-6	2017	AMG was predicted to bind to MAO-B with an energy of -23.1kcal/mol by possible hydrogen-bond formation between an oxygen atom of Ile477 residue and a hydrogen atom (H17) of AMG.	Oxygen	114-120	monoamine oxidase B	Homo sapiens	29-34
15722187-2	2005	Within a few minutes, a cable car facilitates an ascent from 1702 to 2700 m above sea level, where the partial pressure of oxygen is about 550 mmHg (as compared to 760 mmHg at sea level).	Oxygen	123-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	176-179
28838565-8	2017	While administering oxygen flowing at 15 L/min via a mask with a reservoir bag, blood tests revealed high methemoglobin (MetHb) levels at 59.6%.	Oxygen	20-26	hemoglobin subunit gamma 2	Homo sapiens	106-119
15713491-14	2005	This mechanism is likely to be common to other NKCD motif-containing Ras superfamily GTPases, as NO/O2 also facilitates GNE on the redox-active Rap1A and Rab3A GTPases.	Oxygen	100-102	RAP1A, member of RAS oncogene family	Homo sapiens	144-149
28838565-8	2017	While administering oxygen flowing at 15 L/min via a mask with a reservoir bag, blood tests revealed high methemoglobin (MetHb) levels at 59.6%.	Oxygen	20-26	hemoglobin subunit gamma 2	Homo sapiens	121-126
29061864-11	2017	Compared with Gly16Gly and Arg16Gly genotypes, these data suggest the Arg16Arg beta2AR genotype plays a role in the loss of oxidative metabolic efficiency coupled with an inadaptive VA and, hence, smaller alveolar surface area available for O2 transport during submaximal exercise in healthy adults.	Oxygen	241-243	adrenoceptor beta 2	Homo sapiens	79-86
29540697-6	2018	Kaempferol forms hydrogen bonds with the FGFR3 backbone oxygen of Glu555 and Ala558 and the side chain of Lys508.	Oxygen	56-62	fibroblast growth factor receptor 3	Homo sapiens	41-46
29725266-9	2018	Therefore, we detected that hypoxia preconditioned BMSCs with the combined treatment of 1% O2 and 0.5mM DMOG showing up-regulation of Hif-1alpha could enhance the survival rate of BMSCs under severe condition (serum-free medium and 1% O2) in vitro and enhances the angiogenesis and osteogenesis potential of BMSCs under 1% O2 microenvironment in vitro.	Oxygen	91-93	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	134-144
29725266-9	2018	Therefore, we detected that hypoxia preconditioned BMSCs with the combined treatment of 1% O2 and 0.5mM DMOG showing up-regulation of Hif-1alpha could enhance the survival rate of BMSCs under severe condition (serum-free medium and 1% O2) in vitro and enhances the angiogenesis and osteogenesis potential of BMSCs under 1% O2 microenvironment in vitro.	Oxygen	235-237	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	134-144
15764749-7	2005	RESULTS: In the whole study group, circulating leptin levels correlated with BMI (r = 0.30), VFA (r = 0.44), SFA (r = 0.28), apnea-hypopnea index (AHI) [r = 0.48], sleep mean arterial oxygen saturation (Sao(2)) [r = 0.59], and sleep lowest Sao(2) (r = 0.37).	Oxygen	184-190	leptin	Homo sapiens	47-53
29725266-9	2018	Therefore, we detected that hypoxia preconditioned BMSCs with the combined treatment of 1% O2 and 0.5mM DMOG showing up-regulation of Hif-1alpha could enhance the survival rate of BMSCs under severe condition (serum-free medium and 1% O2) in vitro and enhances the angiogenesis and osteogenesis potential of BMSCs under 1% O2 microenvironment in vitro.	Oxygen	235-237	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	134-144
29343514-6	2018	We also observed that the TRPM2 knockdown impairs mitochondrial metabolism, indicated by a decrease in basal and maximal mitochondrial oxygen consumption rates and ATP production.	Oxygen	135-141	transient receptor potential cation channel subfamily M member 2	Homo sapiens	26-31
29518129-6	2018	However, we find that the transcription factors Jun Proto-Oncogene (c-JUN), Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells (NFkappaB) and signal transducer and activator of transcription 3 (STAT3) bind genes regulated after 2hours (hs) of omitted glucose and oxygen before HIF1alpha.	Oxygen	279-285	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-73
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	67-109
29047187-3	2018	Here, we identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues.	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	111-117
28924010-4	2017	Furthermore, in vitro experiments demonstrated that, during oxygen-glucose deprivation, miR-1906 expression was increased in glial cells but decreased in neurons.	Oxygen	60-66	microRNA 1906-1	Mus musculus	88-96
29051216-3	2017	Prolyl 4-hydroxylase domain protein 3 (PHD3) is a cellular oxygen sensor and its expression increased in hypoxia.	Oxygen	59-65	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-37
29062272-10	2017	Moreover, a bioinformatics analysis of data demonstrated that hypothalamic MKP-3 mRNA levels were positively correlated with body weight and negatively correlated to oxygen consumption (VO2) in BXD mice.	Oxygen	166-172	dual specificity phosphatase 6	Mus musculus	75-80
15728336-6	2005	AttDT::tDNA protoplasts showed a much stronger inhibition of oxygen evolution at low pH values when compared to wild-type protoplasts.	Oxygen	61-67	tonoplast dicarboxylate transporter	Arabidopsis thaliana	0-5
28374977-4	2017	Autophagy of CD34+ VEGFR-2+ EPCs isolated from rat bone marrow increased after treatment with 1% O2 .	Oxygen	97-99	CD34 molecule	Rattus norvegicus	13-17
29440497-6	2018	The structures show that inhibition of AHAS by PS triggers expulsion of two molecules of oxygen bound in the active site, releasing them as substrates for an oxygenase side reaction of the enzyme.	Oxygen	89-95	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	39-43
29467012-1	2018	BACKGROUND: The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM).	Oxygen	38-44	O-6-methylguanine-DNA methyltransferase	Homo sapiens	45-82
15699152-6	2005	The data support a mechanism for apoptosis in these cells similar to that found in activation-induced apoptosis through the TCR, resulting in oxygen-free radical production, mitochondrial damage, and caspase-9 activation.	Oxygen	142-148	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	124-127
29467012-1	2018	BACKGROUND: The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM).	Oxygen	38-44	O-6-methylguanine-DNA methyltransferase	Homo sapiens	84-88
28994107-6	2018	Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts.	Oxygen	62-64	lysyl oxidase	Homo sapiens	121-124
29033913-2	2017	In anaerobes, recent findings indicate that the Trx redox network is implicated in the global redox regulation of metabolism but also actively participates in protecting cells against O2.	Oxygen	184-186	trx	Desulfovibrio vulgaris str. Hildenborough	48-51
28890956-0	2017	Spin-dependent transport properties of zigzag phosphorene nanoribbons with oxygen-saturated edges.	Oxygen	75-81	spindlin 1	Homo sapiens	0-4
28994107-6	2018	Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts.	Oxygen	62-64	cadherin 2	Homo sapiens	134-139
15557337-4	2005	To address this question we utilized a HIF-1alpha fusion protein that partially lacks the domain required for oxygen-dependent degradation of HIF-1alpha and that has a VP16 transcriptional activation domain from herpes simplex virus.	Oxygen	110-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	39-49
29452640-2	2018	Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation.	Oxygen	131-137	serine hydroxymethyltransferase 2	Homo sapiens	40-85
29452640-2	2018	Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation.	Oxygen	131-137	serine hydroxymethyltransferase 2	Homo sapiens	87-92
28772282-6	2017	Blocking the oxygen-binding site of HBB reverts the increase of migration and HIF-1alpha upregulation observed in HBB-overexpressing breast cancer cells.	Oxygen	13-19	hemoglobin beta chain complex	Mus musculus	36-39
28772282-6	2017	Blocking the oxygen-binding site of HBB reverts the increase of migration and HIF-1alpha upregulation observed in HBB-overexpressing breast cancer cells.	Oxygen	13-19	hemoglobin beta chain complex	Mus musculus	114-117
15557337-4	2005	To address this question we utilized a HIF-1alpha fusion protein that partially lacks the domain required for oxygen-dependent degradation of HIF-1alpha and that has a VP16 transcriptional activation domain from herpes simplex virus.	Oxygen	110-116	hypoxia inducible factor 1, alpha subunit	Mus musculus	142-152
29277735-7	2018	Six stacks of SiO2/Al2O with a total thickness of approximately 35 nm efficiently prevented oxygen and water molecules from interacting with the CNF film.	Oxygen	92-98	NPHS1 adhesion molecule, nephrin	Homo sapiens	145-148
15602730-4	2005	Quantities of MIP-1alpha were also correlated with lower values of oxygen saturation.	Oxygen	67-73	C-C motif chemokine ligand 3	Homo sapiens	14-24
29277735-8	2018	The oxygen transmission rates analysed at 80% RH decreased from the value for plain CNF film of 130 ml m-2 d-1 to 0.15 ml m-2 d-1, whereas the water transmission rates lowered from 630 +- 50 g m-2 d-1 down to 90 +- 40 g m-2 d-1This article is part of a discussion meeting issue "New horizons for cellulose nanotechnology".	Oxygen	4-10	NPHS1 adhesion molecule, nephrin	Homo sapiens	84-87
28914300-1	2017	A Mn-incorporated Ni(OH)2/carbon fiber cloth (Mn-Ni(OH)2/CFC) fabricated via a room-temperature solution route exhibited superior electrocatalytic activities of the oxygen reduction and urea oxidation reactions, delivering 12-21% energy saving in the charging process of Mn-Ni(OH)2/CFC assembled Zn-air batteries in the presence of 0.5 M urea compared to the battery without urea.	Oxygen	165-171	tubulin folding cofactor C	Homo sapiens	57-60
29507904-10	2018	Moreover, expression of hepatocyte nuclear factor 4alpha (Hnf4alpha) and farnesoid X receptor (Fxr) were better preserved in shaken cultures as a result of improved oxygen delivery.	Oxygen	165-171	hepatic nuclear factor 4, alpha	Mus musculus	24-56
21166153-0	2005	[The state of SHP-1 and CD45 in lymphocyte under high partial pressure of oxygen].	Oxygen	74-80	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	24-28
29507904-10	2018	Moreover, expression of hepatocyte nuclear factor 4alpha (Hnf4alpha) and farnesoid X receptor (Fxr) were better preserved in shaken cultures as a result of improved oxygen delivery.	Oxygen	165-171	hepatic nuclear factor 4, alpha	Mus musculus	58-67
29266417-3	2018	Cu3 P@NPPC demonstrates outstanding activity for both the hydrogen evolution and oxygen reduction reaction, representing the first example of a Cu3 P-based bifunctional catalyst for energy-conversion reactions.	Oxygen	81-87	natriuretic peptide C	Homo sapiens	0-10
29174352-1	2018	As one of the most important environmental factors, oxygen is particularly important for synthesis of n-3 polyunsaturated fatty acids (n-3 PUFA) in microalgae.	Oxygen	52-58	pumilio RNA binding family member 3	Homo sapiens	139-143
28817930-4	2017	Protein X-ray crystallography established that 3-unsubstituted 2,4-oxazolidinediones bound to CA II via an interaction of the acidic ring nitrogen with the CA II active site zinc, as well as two hydrogen bonds between the oxazolidinedione ring oxygen and the CA II protein backbone.	Oxygen	244-250	carbonic anhydrase 2	Homo sapiens	94-99
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Oxygen	220-226	endogenous retrovirus group W member 5	Homo sapiens	54-57
28666065-1	2017	We describe two water-soluble ruthenium complexes, [1]Cl2 and [2]Cl2 , that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm-2 ) of red light in an oxygen-independent manner.	Oxygen	220-226	endogenous retrovirus group W member 5	Homo sapiens	65-68
28715126-5	2017	Towards this goal, we have used molecular dynamics simulations to guide the design of mPKM2 internal light/oxygen/voltage-sensitive domain 2 (LOV2) fusion at position D24 (PiL[D24]), an engineered pyruvate kinase M2 (PKM2) variant that harbours an insertion of the light-sensing LOV2 domain from Avena Sativa within a region implicated in allosteric regulation by fructose 1,6-bisphosphate (FBP).	Oxygen	107-113	serpin family A member 2 (gene/pseudogene)	Homo sapiens	172-175
29240973-2	2018	This air-tolerant ATRP was enabled by the continuous conversion of oxygen to carbon dioxide catalyzed by glucose oxidase (GOx), in the presence of glucose and sodium pyruvate as sequential sacrificial substrates.	Oxygen	67-73	hydroxyacid oxidase 1	Homo sapiens	105-120
29240973-2	2018	This air-tolerant ATRP was enabled by the continuous conversion of oxygen to carbon dioxide catalyzed by glucose oxidase (GOx), in the presence of glucose and sodium pyruvate as sequential sacrificial substrates.	Oxygen	67-73	hydroxyacid oxidase 1	Homo sapiens	122-125
29240973-4	2018	Without added pyruvates, lower MWs were observed due to generation of new chains by H2 O2 formed by reaction of O2 with GOx.	Oxygen	87-89	hydroxyacid oxidase 1	Homo sapiens	120-123
21166153-1	2005	AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte.	Oxygen	119-125	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	83-87
15516695-1	2005	Heme oxygenase-1 (HO-1) catalyzes the physiological degradation of heme at the expense of molecular oxygen using electrons donated by NADPH-cytochrome P450 reductase (CPR).	Oxygen	5-11	heme oxygenase 1	Homo sapiens	18-22
28886566-5	2018	Azo dye, organic carbon and ammonium were majorly removed in the anoxic period wherein bulk dissolved oxygen was ranged from 0.5 and &lt;0.08mgL-1.	Oxygen	102-108	LLGL scribble cell polarity complex component 1	Homo sapiens	141-146
28294416-6	2017	At the molecular level we observed increases in mRNA expression of MuRF-1 only at 1% O2 whereas MAFbx expression was elevated at 10%, 5%, and 1% O2 .	Oxygen	145-147	F-box protein 32	Homo sapiens	96-101
28256000-3	2017	Oxygen reduction rate in the presence of DNP-INT was higher than in the absence of the inhibitor in low light at pH 6.5 and 7.6, showing that the capacity of the plastoquinone pool to reduce molecular oxygen in this case exceeded that of the entire electron transfer chain.	Oxygen	0-6	inturned planar cell polarity protein	Homo sapiens	45-48
28256000-3	2017	Oxygen reduction rate in the presence of DNP-INT was higher than in the absence of the inhibitor in low light at pH 6.5 and 7.6, showing that the capacity of the plastoquinone pool to reduce molecular oxygen in this case exceeded that of the entire electron transfer chain.	Oxygen	201-207	inturned planar cell polarity protein	Homo sapiens	45-48
15603755-7	2005	CYP2E1 is induced by alcohol and the primary P450 that carries out ethanol oxidation that can lead to the production of activated oxygen species and oxidative stress that elevate ERK1/2 phosphorylation through EGRF/c-Raf signaling.	Oxygen	130-136	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
30178328-6	2018	During CA, cerebral oxygen saturation (ScO2) decreased to the lowest level, and then gradually increased during the chest compression period.	Oxygen	20-26	synthesis of cytochrome C oxidase 2	Sus scrofa	39-43
15675979-4	2005	Oxygen uptake was calculated from cardiac output (thermodilution) and the pulmonary av-difference of oxygen after induction of anaesthesia, at the end of surgery, and 1 and 2 h after the CPB.	Oxygen	0-6	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	163-174
29040939-1	2018	In this report, a biomimetic theranostic oxygen (O2)-meter (cancer cell membrane@Pt(II) porphyrinic-metal organic framework, designated as mPPt) was constructed for cancer targeted and phosphorescence image-guided photodynamic therapy (PDT).	Oxygen	41-47	palmitoyl-protein thioesterase 1	Mus musculus	139-143
29040939-1	2018	In this report, a biomimetic theranostic oxygen (O2)-meter (cancer cell membrane@Pt(II) porphyrinic-metal organic framework, designated as mPPt) was constructed for cancer targeted and phosphorescence image-guided photodynamic therapy (PDT).	Oxygen	49-51	palmitoyl-protein thioesterase 1	Mus musculus	139-143
28912721-9	2017	Results: Conditions of hyperglycaemia are characterized by a low affinity of hemoglobin to oxygen, which is manifested as a parallel decrease in the content of hemoglobin oxyform and the growth of deoxyform, methemoglobin and membrane-bound hemoglobin.	Oxygen	91-97	hemoglobin subunit gamma 2	Homo sapiens	208-221
16101451-5	2005	Some K2P channels are activated by certain physical and chemical factors such as lipids, volatile anesthetics, heat, oxygen, protons and membrane tension.	Oxygen	117-123	keratin 76	Homo sapiens	5-8
28813675-5	2017	The CD44ICD was sufficient to induce hypoxic signaling at perivascular oxygen tensions, and blocking CD44 cleavage decreased HIF-2alpha stabilization in CD44-expressing cells.	Oxygen	71-77	CD44 molecule (Indian blood group)	Homo sapiens	4-11
28813675-5	2017	The CD44ICD was sufficient to induce hypoxic signaling at perivascular oxygen tensions, and blocking CD44 cleavage decreased HIF-2alpha stabilization in CD44-expressing cells.	Oxygen	71-77	CD44 molecule (Indian blood group)	Homo sapiens	4-8
28813675-6	2017	Our data indicate that the stem cell marker CD44 modulates the hypoxic response of glioma cells and that the pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2alpha through interaction with CD44, independently of oxygen.	Oxygen	251-257	CD44 molecule (Indian blood group)	Homo sapiens	228-232
29040939-2	2018	mPPt presents high photosensitizers (PSs) loading and evitable self-quenching behaviors for favorable biological O2 sensing and PDT.	Oxygen	113-115	palmitoyl-protein thioesterase 1	Mus musculus	0-4
29040939-4	2018	Importantly, the O2-dependent phosphorescence responsibility of mPPt could be employed to pre-evaluate the real time O2 level in situ and guide the PDT under light irradiation.	Oxygen	17-19	palmitoyl-protein thioesterase 1	Mus musculus	64-68
29040939-4	2018	Importantly, the O2-dependent phosphorescence responsibility of mPPt could be employed to pre-evaluate the real time O2 level in situ and guide the PDT under light irradiation.	Oxygen	117-119	palmitoyl-protein thioesterase 1	Mus musculus	64-68
31258285-3	2018	Excess H2 consumption during TPR is indicative of partial support reduction, which was confirmed by O2 titration.	Oxygen	100-102	translocated promoter region, nuclear basket protein	Homo sapiens	29-32
29042140-9	2018	Our data show that myeloid-derived cells contribute to pathological neovascularization in oxygen-induced retinopathy through activation of VEGF-A expression in Muller cells.	Oxygen	90-96	vascular endothelial growth factor A	Mus musculus	139-145
28593650-0	2017	Delocalized Spin States in 2D Atomic Layers Realizing Enhanced Electrocatalytic Oxygen Evolution.	Oxygen	80-86	spindlin 1	Homo sapiens	12-16
28853500-6	2017	The fluorescence intensities of actin and vimentin were lowest at 4% O2(P&lt;0.05), whereas that of tubulin was highest at 2% O2 (P&lt;0.05).	Oxygen	69-71	vimentin	Capra hircus	42-50
28853500-10	2017	Vimentin mRNA expression was lowest at 4% O2 and highest at 21% O2, and significant differences were observed between vimentin mRNA expression levels among these oxygen levels (P&lt;0.05).	Oxygen	42-44	vimentin	Capra hircus	0-8
29115415-4	2018	In the present study, we used MCF7 breast cancer cells and confirmed that a combination of IFN-alpha/beta/gamma incubation induced STAT1/3 phosphorylation and mitochondria importation, which increased mitochondria respiratory complexes, the cellular oxygen consumption rate (OCR), and ROS production, followed by cellular apoptosis.	Oxygen	250-256	signal transducer and activator of transcription 1	Homo sapiens	131-138
15589383-5	2005	We suggest that the relatively high levels of O(2)(-) in the cytosol and intermembrane space of the SOD1 mutant may react with endogenous NO, forming HOONO that can diffuse into the mitochondrial matrix and there inactivate Lys4p and other [4Fe-4S]-containing dehydratases.	Oxygen	46-50	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	224-229
28382740-8	2017	Based on SDH, the maximal oxygen consumption supported by a capillary did not differ significantly between young and old people.	Oxygen	26-32	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	9-12
28728562-8	2017	The transcription levels of MnSOD, PRDX5, VEGF and GLUT-3 also significantly increased in 3% O2 compared with 20% O2 (P &lt; 0.05).	Oxygen	93-95	vascular endothelial growth factor A	Mus musculus	42-46
29218634-2	2018	N2OR is the terminal reductase in a respiratory chain converting N2O to N2 in denitrifying bacteria; COX is the terminal oxidase of the aerobic respiratory chain of certain bacteria and eukaryotic organisms transforming O2 to H2O accompanied by proton pumping.	Oxygen	220-222	cytochrome c oxidase subunit 7A1	Bos taurus	101-104
15515055-0	2005	Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst.	Oxygen	0-6	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	31-37
29592784-0	2018	The analgesic effect of early hyperbaric oxygen treatment in chronic constriction injury rats and its influence on nNOS and iNOS expression and inflammatory factor production.	Oxygen	41-47	nitric oxide synthase 1	Rattus norvegicus	115-119
28356444-9	2017	Tspan12/beta-catenin signaling was activated in response to acute and chronic stress in the oxygen-induced retinopathy and very low density lipoprotein receptor mouse model of proliferative retinopathy.	Oxygen	92-98	catenin (cadherin associated protein), beta 1	Mus musculus	8-20
15515055-0	2005	Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst.	Oxygen	0-6	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	39-45
15515055-8	2005	Expression of GLUT-1, GLUT-3, and vascular endothelial growth (VEGF) was increased by 2- to 4-fold in embryos cultured under 2% oxygen, when compared to embryos cultured under 20 or 7% oxygen, and when compared to embryos developed in vivo (all P &lt; 0.001).	Oxygen	128-134	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	14-20
15515055-8	2005	Expression of GLUT-1, GLUT-3, and vascular endothelial growth (VEGF) was increased by 2- to 4-fold in embryos cultured under 2% oxygen, when compared to embryos cultured under 20 or 7% oxygen, and when compared to embryos developed in vivo (all P &lt; 0.001).	Oxygen	128-134	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	22-28
15515055-8	2005	Expression of GLUT-1, GLUT-3, and vascular endothelial growth (VEGF) was increased by 2- to 4-fold in embryos cultured under 2% oxygen, when compared to embryos cultured under 20 or 7% oxygen, and when compared to embryos developed in vivo (all P &lt; 0.001).	Oxygen	185-191	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	14-20
28795375-6	2018	We identified 10 and five quantitative trait-associated mutations for oxygen saturation (SaO2) and blood platelet count, respectively, at the EDAR locus.	Oxygen	70-76	ectodysplasin A receptor	Homo sapiens	142-146
28484090-6	2017	We show that treatment of tumor cells with HSP70 inhibitors causes a marked change in mitochondrial protein quality control, loss of mitochondrial membrane potential, reduced oxygen consumption rate, and loss of ATP production.	Oxygen	175-181	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-48
15780476-4	2005	Intrathecal infusion of Flk-1 antisense ODNs for 7 days suppressed almost completely Flk-1 expression in the lumbar segment of the spinal cord and was followed by a hypoxic challenge with 12% oxygen for 1 h that was repeated for 7 more days.	Oxygen	192-198	kinase insert domain receptor	Rattus norvegicus	24-29
28890842-5	2017	The mechanistic insights not only provide a mechanistic base for future rational design of uricase mutants with improved catalytic activity against uric acid as an improved enzyme therapy, but also are valuable for understanding a variety of other cofactor-free oxidase-catalyzed reactions involving an oxygen molecule.	Oxygen	303-309	urate oxidase (pseudogene)	Homo sapiens	91-98
29119659-5	2017	Moreover, the GOx@ZIF-8(NiPd) modified electrode showed good bioactivity of GOx and high electrocatalytic activity for the oxygen reduction reaction (ORR), which could also be used for electrochemical detection of glucose.	Oxygen	123-129	hydroxyacid oxidase 1	Homo sapiens	14-17
29119659-5	2017	Moreover, the GOx@ZIF-8(NiPd) modified electrode showed good bioactivity of GOx and high electrocatalytic activity for the oxygen reduction reaction (ORR), which could also be used for electrochemical detection of glucose.	Oxygen	123-129	hydroxyacid oxidase 1	Homo sapiens	76-79
15974836-1	2005	The heat shock protein 70 (HSP70) is a key component of the stress response induced by various noxious conditions such as heat, oxygen stress, trauma and infection.	Oxygen	128-134	heat shock 70 kDa protein 1	Canis lupus familiaris	4-25
29216269-9	2017	Overall, these data define a role of NGB as compensatory protein in the cell machinery activated in response to stress and as general stress adaptation marker of cancer cells susceptible to oxidative stress, oxygen and, as demonstrated here for the first time, even to nutrient willingness.	Oxygen	208-214	neuroglobin	Homo sapiens	37-40
29221388-3	2017	Reactions of SmS+ with Xe, CO, and O2 are examined.	Oxygen	35-37	spermine synthase	Homo sapiens	13-16
28987725-12	2017	RESULTS: Tunicamycin, 20% mechanical forces and hypoxia (1% O2) all significantly increased chondrocytes apoptosis rates and expression of ERS markers (GRP78, GRP94 and Caspase 12).	Oxygen	60-62	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	152-157
28512254-4	2017	Epac1-deficient mice showed a reduced amount of pre-retinal neovascularizations in the model of oxygen-induced retinopathy, which is predominantly driven by vascular endothelial growth factor (VEGF).	Oxygen	96-102	vascular endothelial growth factor A	Mus musculus	157-191
28512254-4	2017	Epac1-deficient mice showed a reduced amount of pre-retinal neovascularizations in the model of oxygen-induced retinopathy, which is predominantly driven by vascular endothelial growth factor (VEGF).	Oxygen	96-102	vascular endothelial growth factor A	Mus musculus	193-197
28017782-3	2017	Presumably, deficiency for Parkin or PINK1 impairs mitochondrial autophagy and thereby increases oxidative stress due to the accumulation of dysfunctional mitochondria that release reactive oxygen species.	Oxygen	190-196	PTEN induced kinase 1	Homo sapiens	37-42
28400392-4	2017	Immunohistochemical staining for RUNX1 showed reactivity in vessels of patient-derived FVMs and angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.	Oxygen	140-146	runt related transcription factor 1	Mus musculus	184-189
28987725-12	2017	RESULTS: Tunicamycin, 20% mechanical forces and hypoxia (1% O2) all significantly increased chondrocytes apoptosis rates and expression of ERS markers (GRP78, GRP94 and Caspase 12).	Oxygen	60-62	caspase 12	Rattus norvegicus	169-179
15974836-1	2005	The heat shock protein 70 (HSP70) is a key component of the stress response induced by various noxious conditions such as heat, oxygen stress, trauma and infection.	Oxygen	128-134	heat shock 70 kDa protein 1	Canis lupus familiaris	27-32
28578372-10	2017	Moreover, N- CPAP was significantly more effective in increasing post-treatment lowest Oxygen Saturation level than OA.	Oxygen	87-93	centromere protein J	Homo sapiens	13-17
16206856-11	2005	Therefore, it is concluded that the ASM1 based sewer model properly describes the changes in dissolved oxygen level in an aerobic sewer reach.	Oxygen	103-109	H19 imprinted maternally expressed transcript	Homo sapiens	36-40
27998200-3	2017	Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (Nox4) produces reactive oxygen species (ROS) in sarcoplasmic reticulum (SR) and has been identified as an important O2 sensor in skeletal muscle.	Oxygen	179-181	NADPH oxidase 4	Rattus norvegicus	0-61
27998200-3	2017	Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (Nox4) produces reactive oxygen species (ROS) in sarcoplasmic reticulum (SR) and has been identified as an important O2 sensor in skeletal muscle.	Oxygen	179-181	NADPH oxidase 4	Rattus norvegicus	63-67
28941626-9	2017	In vitro study revealed that the autophagy inducer rapamycin and TRIB3 overexpression cancelled PTP1B ablation-offered beneficial effects on cardiomyocyte function or O2- production in murine cardiomyocytes or H9C2 myoblasts.	Oxygen	167-169	tribbles pseudokinase 3	Mus musculus	65-70
28941626-9	2017	In vitro study revealed that the autophagy inducer rapamycin and TRIB3 overexpression cancelled PTP1B ablation-offered beneficial effects on cardiomyocyte function or O2- production in murine cardiomyocytes or H9C2 myoblasts.	Oxygen	167-169	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	96-101
29185409-2	2017	The delivery of oxygen to tissues is impaired and cellular hypoxia develops with an increase in MetHb levels.	Oxygen	16-22	hemoglobin subunit gamma 2	Homo sapiens	96-101
15584734-5	2004	The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2.	Oxygen	309-311	acrosin	Homo sapiens	93-96
15584734-5	2004	The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2.	Oxygen	309-311	acrosin	Homo sapiens	162-165
29163184-3	2017	Here, we identified that NAC1-PDK3 axis as necessary for suppression of mitochondrial function, oxygen consumption, and more harmful ROS generation and protects cancer cells from apoptosis in hypoxia.	Oxygen	96-102	pyruvate dehydrogenase kinase, isoenzyme 3	Mus musculus	30-34
15584734-5	2004	The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2.	Oxygen	309-311	acrosin	Homo sapiens	162-165
27829319-0	2017	Effect of different concentrations of oxygen on expression of sigma 1 receptor and superoxide dismutases in human colon adenocarcinoma cell lines.	Oxygen	38-44	sigma non-opioid intracellular receptor 1	Homo sapiens	62-78
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	2-8	caspase 3	Mus musculus	118-127
15571384-4	2004	These observations implicate a decarboxylation mechanism in which Pro-1 polarizes the carbonyl oxygen of substrate by hydrogen bonding and/or an electrostatic interaction.	Oxygen	95-101	lamin A/C	Homo sapiens	66-71
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	caspase 3	Mus musculus	118-127
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	caspase 3	Mus musculus	118-127
28498432-0	2017	Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells.	Oxygen	10-16	N-myc downstream regulated 1	Homo sapiens	56-61
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	myoglobin	Homo sapiens	34-43
28052587-2	2017	WORKING HYPOTHESIS: We hypothesize that therapy with dornase alfa will be safe and well tolerated in the preterm population with no worsening of symptoms, oxygen requirement, or need for respiratory support.	Oxygen	155-161	deoxyribonuclease 1	Homo sapiens	53-65
29132470-1	2017	OBJECTIVE: To explore the effects of rat bone mesenchymal stem cell (BMSC) transplantation on retinal neovascularization, and to observe the changes of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factors (VEGF) in rats with oxygen-induced retinopathy (OIR).	Oxygen	258-264	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	186-196
29187867-3	2017	It has been suggested, that lower oxygen tension, may modulate the IREB2 and FAM13A activity.	Oxygen	34-40	family with sequence similarity 13 member A	Homo sapiens	77-83
28877584-2	2017	We investigated the relationship between atmospheres and alternative oxidase (AOX) to cytochrome c oxidase (COX) activities (on the basis of oxygen isotope discrimination) and the relative amounts of two respiratory enzymes, AOX and COX, during the early stage of storage.	Oxygen	141-147	acyl-CoA oxidase 1	Homo sapiens	57-76
28877584-2	2017	We investigated the relationship between atmospheres and alternative oxidase (AOX) to cytochrome c oxidase (COX) activities (on the basis of oxygen isotope discrimination) and the relative amounts of two respiratory enzymes, AOX and COX, during the early stage of storage.	Oxygen	141-147	acyl-CoA oxidase 1	Homo sapiens	78-81
28877584-6	2017	Oxygen isotope discrimination was elevated under hypoxia after 50.5 h. AOX production in broccoli was controlled more by changing atmospheres than by COX.	Oxygen	0-6	acyl-CoA oxidase 1	Homo sapiens	71-74
28363867-6	2017	DRG2 depletion reduced the mitochondrial membrane potential, oxygen consumption rate (OCR), and amount of mitochondrial DNA (mtDNA), whereas it increased reactive oxygen species (ROS) production and apoptosis.	Oxygen	61-67	developmentally regulated GTP binding protein 2	Homo sapiens	0-4
28361267-2	2017	This has led to the development of pharmacological agents for anti-angiogenesis to disrupt the vascular supply and starve tumor of nutrients and oxygen, primarily through blockade of VEGF/VEGFR signaling.	Oxygen	145-151	kinase insert domain receptor	Homo sapiens	188-193
28891289-3	2017	By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine).	Oxygen	249-251	tyrosinase	Homo sapiens	116-126
28549090-0	2017	Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells.	Oxygen	66-72	sigma non-opioid intracellular receptor 1	Homo sapiens	0-16
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	myoglobin	Homo sapiens	45-47
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	myoglobin	Homo sapiens	34-43
28549090-2	2017	This study seeks to determine the effects of the sigma-1 receptor (sigma-1r) and its agonists on mitochondrial function in oxygen- and glucose- deprived (OGD) purified neonatal RGCs.	Oxygen	123-129	sigma non-opioid intracellular receptor 1	Homo sapiens	49-65
28549090-2	2017	This study seeks to determine the effects of the sigma-1 receptor (sigma-1r) and its agonists on mitochondrial function in oxygen- and glucose- deprived (OGD) purified neonatal RGCs.	Oxygen	123-129	sigma non-opioid intracellular receptor 1	Homo sapiens	67-75
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	myoglobin	Homo sapiens	45-47
28549090-9	2017	Oxygen and glucose depreavtation induced decreases in cytochrome c activity were partially restored by overexpression or activation of sigma-1r.	Oxygen	0-6	sigma non-opioid intracellular receptor 1	Homo sapiens	135-143
28646017-5	2017	Here we showed that retinoic acid receptor-related orphan receptor alpha (RORalpha), a nuclear receptor and transcription factor, is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in a mouse model of oxygen-induced proliferative retinopathy.	Oxygen	229-235	RAR related orphan receptor A	Homo sapiens	74-82
15520865-3	2004	c-Cbl-/- mice exhibited a profound increase in whole-body energy expenditure as determined by increased core temperature and whole-body oxygen consumption.	Oxygen	136-142	Casitas B-lineage lymphoma	Mus musculus	0-5
28890242-0	2017	Asphyxiation death caused by oxygen-depleting cargo on a ship.	Oxygen	29-35	inositol polyphosphate-5-phosphatase D	Homo sapiens	57-61
28246171-10	2017	This study provides mechanistic insights into how the distal heme ligand in neuroglobin caps its reactivity toward H2S and identifies by cryo-mass spectrometry a range of sulfide oxidation products with 2-6 catenated sulfur atoms with or without oxygen insertion, which accumulate in the absence of the His64 ligand.	Oxygen	246-252	neuroglobin	Homo sapiens	76-87
28675767-0	2017	Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway.	Oxygen	51-57	sirtuin 7	Homo sapiens	0-8
15456249-5	2004	Sulfur and oxygen linked heterocycles as well as those without heteroatom linkers were found to provide potent inhibitors of cathepsin K.	Oxygen	11-17	cathepsin K	Homo sapiens	125-136
28675767-3	2017	In this study, we aimed to investigate the potential role of SIRT7 in regulating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury in neurons.	Oxygen	81-87	sirtuin 7	Homo sapiens	61-66
28822272-3	2017	This drug prefers to attach via its oxygen atoms to the B atoms of the cluster with adsorption energy about -11.90kcalmol-1 based on the dispersion corrected B3LYP level of theory.	Oxygen	36-42	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	160-163
28328204-5	2017	According to DFT calculations (B3LYP/6-311+G(d,p)) the rearrangement proceeds via intermediate formation of a diazo compound, and can be catalyzed by acids via the protonation of oxygen atom of the sulfonamide group.	Oxygen	179-185	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	33-36
15205261-5	2004	We find that EPOR is inducible by EPO in primary human endothelial cells of vein (HUVECs) and artery (HUAECs) and cells from a human bone marrow microvascular endothelial line (TrHBMEC) to a much greater extent at low oxygen tension than in room air.	Oxygen	218-224	erythropoietin receptor	Homo sapiens	13-17
28284922-5	2017	We first evaluated the effect of soluble GOX on inducing solution hypoxia (O2&lt;5%) and found that both unmodified and acrylated GOX could sustain hypoxia for at least 24h even under ambient air condition with constant oxygen diffusion from the air-liquid interface.	Oxygen	220-226	hydroxyacid oxidase 1	Homo sapiens	130-133
28958347-7	2017	Patients in the highest tertile of GDF-15 were older and had measurements of more severe HF (higher N-terminal pro-B-type natriuretic peptide [NT-proBNP] concentrations and lower peak oxygen uptake on cardiopulmonary exercise testing [CPX]).	Oxygen	184-190	growth differentiation factor 15	Homo sapiens	35-41
28714612-7	2017	CPAP/NIV was discontinued following spontaneous improvement of sleep-disordered breathing in 33 (57%) patients, upper airway surgery (n = 14, 24%), maxillofacial surgery (n = 6, 11%), neurosurgery (n = 1, 2%), upper airway and neurosurgery (n = 2, 3%), or switch to oxygen therapy (n = 2, 3%).	Oxygen	266-272	centromere protein J	Homo sapiens	0-8
15205261-9	2004	These results suggest that low oxygen tension increases endothelial cell capacity to produce NO in response to EPO by induction of both EPOR and eNOS.	Oxygen	31-37	erythropoietin receptor	Homo sapiens	136-140
28423052-1	2017	INTRODUCTION: Hypoxia-inducible factor 1-alpha (HIF-1alpha) is the oxygen-sensitive subunit of the transcription factor HIF-1, and its expression is increased in placentas from pregnancies complicated by pre-eclampsia (PE).	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-46
28423052-1	2017	INTRODUCTION: Hypoxia-inducible factor 1-alpha (HIF-1alpha) is the oxygen-sensitive subunit of the transcription factor HIF-1, and its expression is increased in placentas from pregnancies complicated by pre-eclampsia (PE).	Oxygen	67-73	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	48-58
28957413-6	2017	TERT-hBA adipocytes were UCP1-positive and responded to beta-adrenergic stimulation by activating the PKA-MKK3/6-p38 MAPK signaling module and increasing thermogenic gene expression and oxygen consumption.	Oxygen	186-192	keratin 90, pseudogene	Homo sapiens	5-8
28839175-5	2017	Further, significant hypermethylation was observed in promoter DNA region of BRCA1 due to oxygen nanobubble (ONB) treatment.	Oxygen	90-96	breast cancer 1, early onset	Mus musculus	77-82
28393867-4	2017	Mice with endothelial-specific Lrp1 deletion display improved glucose sensitivity and lipid profiles combined with increased oxygen consumption during high-fat-diet-induced obesity.	Oxygen	125-131	low density lipoprotein receptor-related protein 1	Mus musculus	31-35
15379511-1	2004	We report an approach for immobilizing iso-1-cytochrome c from Saccharomyces cerevisiae on oxygen exposing surfaces derivatized with SH-terminated silanes.	Oxygen	91-97	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	39-44
28054425-4	2017	We demonstrate that a loss-of-function mutation in the neuropeptide receptor gene npr-1 and a deletion mutation in the atypical soluble guanylate cyclase gcy-35 O2 sensor interact synergistically to extend worm lifespan.	Oxygen	161-163	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	82-87
28054425-5	2017	The function of npr-1 and gcy-35 in the O2 -sensing neurons AQR, PQR, and URX shortens the lifespan of the worm.	Oxygen	40-42	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	16-21
28678482-4	2017	The O2 adsorption energy on pure and bimetallic clusters and the ensuing geometries depend on the spin multiplicity of the system.	Oxygen	4-6	spindlin 1	Homo sapiens	98-102
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	126-132	hypoxia inducible factor 1, alpha subunit	Mus musculus	46-55
28472708-2	2017	The pulsed corona discharge in contact with liquid, operated in oxygen, produced 3.5mgL-1 ozone, which was subsequently introduced in the ozonation reactor.	Oxygen	64-70	LLGL scribble cell polarity complex component 1	Homo sapiens	84-89
28266966-3	2017	PHD1 to PHD3 are molecular oxygen sensors and increasingly considered as putative therapeutic targets.	Oxygen	27-33	egl-9 family hypoxia-inducible factor 2	Mus musculus	0-4
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	126-132	aryl hydrocarbon receptor nuclear translocator	Mus musculus	60-64
28715185-1	2017	The human heme enzyme tryptophan 2,3-dioxygenase (hTDO) catalyzes the insertion of dioxygen into its cognate substrate, l-tryptophan (l-Trp).	Oxygen	37-45	tryptophan 2,3-dioxygenase	Homo sapiens	50-54
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	126-132	aryl hydrocarbon receptor nuclear translocator	Mus musculus	66-74
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	134-138	hypoxia inducible factor 1, alpha subunit	Mus musculus	46-55
28096235-4	2017	The circadian rhythmicity of oxygen consumption rate (Vo2) was disrupted in aged obese CT-1-deficient (CT-1-/-) mice (12 mo).	Oxygen	29-35	cardiotrophin 1	Mus musculus	87-91
28096235-4	2017	The circadian rhythmicity of oxygen consumption rate (Vo2) was disrupted in aged obese CT-1-deficient (CT-1-/-) mice (12 mo).	Oxygen	29-35	cardiotrophin 1	Mus musculus	103-107
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	134-138	aryl hydrocarbon receptor nuclear translocator	Mus musculus	60-64
28583798-4	2017	For the better inhibitors, molecular docking results suggested that the oxygen present in the para position of the aromatic ring is essential for the tyrosinase inhibition, due its high ability for complexation with Cu2+ ions.	Oxygen	72-78	tyrosinase	Homo sapiens	150-160
15342485-1	2004	Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation.	Oxygen	134-138	aryl hydrocarbon receptor nuclear translocator	Mus musculus	66-74
15339940-1	2004	Myoglobin is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin ring:iron ion complex.	Oxygen	137-139	myoglobin	Homo sapiens	0-9
27796296-7	2017	IL-22 stimulation of hepatocytes incubated in low oxygen led to reduced levels of activated signal transducer and activator of transcription 3 and further downstream effects such as reduced induction of the anti-microbial protein, lipocalin-2.	Oxygen	50-56	interleukin 22	Homo sapiens	0-5
27796296-7	2017	IL-22 stimulation of hepatocytes incubated in low oxygen led to reduced levels of activated signal transducer and activator of transcription 3 and further downstream effects such as reduced induction of the anti-microbial protein, lipocalin-2.	Oxygen	50-56	lipocalin 2	Homo sapiens	231-242
28622713-10	2017	Lose of SDHB by miR-142-5p inhibited oxygen intake by CRC cells, but increased glucose consumption and lactate production.	Oxygen	37-43	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	8-12
15325179-1	2004	In this study, the relative importance of the dual reaction pathways of CO2*- in the photo/ferrioxalate system, where it acts both as a reductant for reducing the ferric ion and as an agent for the formation of H(2)O(2), was investigated as a function of the concentrations of ferrioxalate and oxygen.	Oxygen	294-300	complement C2	Homo sapiens	72-75
28853500-10	2017	Vimentin mRNA expression was lowest at 4% O2 and highest at 21% O2, and significant differences were observed between vimentin mRNA expression levels among these oxygen levels (P&lt;0.05).	Oxygen	64-66	vimentin	Capra hircus	0-8
29082365-13	2017	CONCLUSION: Continuous exposure of 2 MAC sevoflurane in 2 lit/min O2 simultaneous during prepubertal may create more testicular tissue damage in terms of cellular and molecular function compared to continuous exposure to lower level of sevoflurane by increase in ratio of Bax/Bcl2 and apoptosis in germ cells after puberty.	Oxygen	66-68	BCL2-associated X protein	Mus musculus	272-275
26927658-7	2017	Interestingly, the expression of cold inducible RNA-binding protein (CIRBP), a cold responsive gene reacting to multiple cellular stresses, was decreased in parallel with the 1 % oxygen-induced proliferation inhibition.	Oxygen	179-185	cold inducible RNA binding protein	Mus musculus	33-67
26927658-7	2017	Interestingly, the expression of cold inducible RNA-binding protein (CIRBP), a cold responsive gene reacting to multiple cellular stresses, was decreased in parallel with the 1 % oxygen-induced proliferation inhibition.	Oxygen	179-185	cold inducible RNA binding protein	Mus musculus	69-74
15325179-2	2004	We studied the two competitive reactions of CO2*- in the photo/ferrioxalate system, which depend on the relative concentrations of ferrioxalate to oxygen, with the degradation of 2,4-dichlorophenoxyacetic acid (2,4-D), which was used as a target pollutant.	Oxygen	147-153	complement C2	Homo sapiens	44-47
28452782-7	2017	In the laboratory-scale reactor, the O2 mass transfer coefficient was found to depend on the stirring rate (rph) as follows: KL,O2 = 0.016 + 0.025 N3.85.	Oxygen	37-39	immunoglobulin kappa variable 1D-39	Homo sapiens	125-130
28230974-1	2017	The magnetic characteristics of hemoglobin (Hb) changes with the binding of dioxygen (O2) to the heme prosthetic groups of the globin chains: from paramagnetic ferrous Hb to diamagnetic ferrous oxyhemoglobin (oxyHb) with reversibly bound O2, or paramagnetic ferric methemoglobin (metHb).	Oxygen	76-84	hemoglobin subunit gamma 2	Homo sapiens	265-278
28230974-1	2017	The magnetic characteristics of hemoglobin (Hb) changes with the binding of dioxygen (O2) to the heme prosthetic groups of the globin chains: from paramagnetic ferrous Hb to diamagnetic ferrous oxyhemoglobin (oxyHb) with reversibly bound O2, or paramagnetic ferric methemoglobin (metHb).	Oxygen	86-88	hemoglobin subunit gamma 2	Homo sapiens	265-278
28194805-3	2017	Low blood oxygen concentrations increase fetal plasma catecholamine concentrations, which lower fetal insulin concentrations.	Oxygen	10-16	LOC105613195	Ovis aries	102-109
28410532-4	2017	Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, which was recued by BMI-1 silencing.	Oxygen	36-42	SRY-box transcription factor 2	Homo sapiens	87-91
28410532-4	2017	Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, which was recued by BMI-1 silencing.	Oxygen	36-42	Kruppel like factor 4	Homo sapiens	93-97
15325179-3	2004	At high concentrations of ferrioxalate, almost all of the CO2*- reacted with ferrioxalate to reduce Fe(III) to Fe(II), whereas at low concentrations of ferrioxalate, a majority of the CO2*- contributed to the formation of H(2)O(2), as a result of its reaction with oxygen, which allows the Fenton reaction to occur without any external supply of H(2)O(2).	Oxygen	265-271	complement C2	Homo sapiens	58-61
28322326-3	2017	Here, we show superoxide dismutase-1 (SOD-1), an enzyme that converts superoxide into less toxic hydrogen peroxide and oxygen, functions in the gustatory neuron ASER to mediate C. elegans pathogen avoidance response.	Oxygen	119-125	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	14-36
28322326-3	2017	Here, we show superoxide dismutase-1 (SOD-1), an enzyme that converts superoxide into less toxic hydrogen peroxide and oxygen, functions in the gustatory neuron ASER to mediate C. elegans pathogen avoidance response.	Oxygen	119-125	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	38-43
15325179-3	2004	At high concentrations of ferrioxalate, almost all of the CO2*- reacted with ferrioxalate to reduce Fe(III) to Fe(II), whereas at low concentrations of ferrioxalate, a majority of the CO2*- contributed to the formation of H(2)O(2), as a result of its reaction with oxygen, which allows the Fenton reaction to occur without any external supply of H(2)O(2).	Oxygen	265-271	complement C2	Homo sapiens	184-187
28463769-0	2017	Stable hydrogen and oxygen isotopes of tap water reveal structure of the San Francisco Bay Area"s water system and adjustments during a major drought.	Oxygen	20-26	nuclear RNA export factor 1	Homo sapiens	39-42
15229867-4	2004	NHE1 plays a key role in the regulation of cell volume and pH, and consequently in the control of such diverse processes as blood O2/CO2 transport, and cell proliferation, motility, and survival.	Oxygen	130-132	solute carrier family 9 member A1	Canis lupus familiaris	0-4
28746349-3	2017	We have previously reported altered erythrocyte adenine nucleotide levels corresponding to altered oxygen saturation in mice deficient in both CD73 and AMPD3.	Oxygen	99-105	adenosine monophosphate deaminase 3	Mus musculus	152-157
28177744-8	2017	Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 +- 0.01 L min-1, p &lt; 0.001; 0.52 +- 0.03 L min-1, p &lt; 0.001; 0.35 +- 0.01 L min-1, respectively).	Oxygen	11-17	alcohol dehydrogenase iron containing 1	Homo sapiens	63-66
15170356-13	2004	Alternatively, the oxirane undergoes a nucleophilic substitution reaction where the conjugate base of Pro-1 functions as the nucleophile and an acid catalyst polarizes the carbon oxygen bond.	Oxygen	179-185	lamin A/C	Homo sapiens	102-107
28235047-9	2017	Initially, hypothalamic over-expression of VGF in adult Siberian hamsters produced no effect on metabolic parameters, but by 12 weeks post-infusion hamsters had increased oxygen consumption and a tendency to increased carbon dioxide production; this attenuated body weight gain, reduced interscapular white adipose tissue and resulted in a compensatory increase in food intake.	Oxygen	171-177	VGF nerve growth factor inducible	Mus musculus	43-46
28230075-0	2017	Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1alpha.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	91-101
28679635-0	2017	Reply to Kiser: Dioxygen binding in NOV1 crystal structures.	Oxygen	16-24	chromosome 11 putative open reading frame 40	Homo sapiens	36-40
28679636-0	2017	Reappraisal of dioxygen binding in NOV1 crystal structures.	Oxygen	15-23	chromosome 11 putative open reading frame 40	Homo sapiens	35-39
28838128-7	2017	Identified key oxygen-sensing domains (PAS, GCS, GAF and PHD) in mammalian systems are used to predict the potential plant counterparts in Arabidopsis.	Oxygen	15-21	fibroblast growth factor 9	Homo sapiens	49-52
15240394-6	2004	Oxygen reduction to 5% increased PNMT promoter-driven luciferase expression, with maximum activity at 6 h. Pretreatment of the cells with protein kinase A (PKA) and protein kinase C (PKC) inhibitors, H-89 and GF109203X, respectively, attenuated the rise in luciferase.	Oxygen	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	33-37
28778513-12	2017	Oxygen consumption was lower at T0 and at T180 in RTP10 compared with RTP0 and at all time points except T30 compared with RTP5.	Oxygen	0-6	receptor transporter protein 5 (putative)	Homo sapiens	50-55
28778513-12	2017	Oxygen consumption was lower at T0 and at T180 in RTP10 compared with RTP0 and at all time points except T30 compared with RTP5.	Oxygen	0-6	receptor transporter protein 5 (putative)	Homo sapiens	123-127
28778513-13	2017	Oxygen extraction was lower at T0 in RTP10 compared with RTP0 and RTP5, and at T60 and T180 compared with RTP5.	Oxygen	0-6	receptor transporter protein 5 (putative)	Homo sapiens	37-42
28778513-13	2017	Oxygen extraction was lower at T0 in RTP10 compared with RTP0 and RTP5, and at T60 and T180 compared with RTP5.	Oxygen	0-6	receptor transporter protein 5 (putative)	Homo sapiens	66-70
28230075-6	2017	Expression of MBP, CNP, Olig1, Sox9 and Sox10 was lower at 21% O2, while Nrf2, SOD2, nitrotyrosine were increased.	Oxygen	63-65	myelin basic protein	Rattus norvegicus	14-17
28230075-6	2017	Expression of MBP, CNP, Olig1, Sox9 and Sox10 was lower at 21% O2, while Nrf2, SOD2, nitrotyrosine were increased.	Oxygen	63-65	SRY-box transcription factor 9	Rattus norvegicus	31-35
28230075-6	2017	Expression of MBP, CNP, Olig1, Sox9 and Sox10 was lower at 21% O2, while Nrf2, SOD2, nitrotyrosine were increased.	Oxygen	63-65	SRY-box transcription factor 10	Rattus norvegicus	40-45
28230075-8	2017	Luciferease reporter assay in OLN93 cells indicated increased Hif-1alpha activity at 5% O2.	Oxygen	88-90	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	62-72
15240394-6	2004	Oxygen reduction to 5% increased PNMT promoter-driven luciferase expression, with maximum activity at 6 h. Pretreatment of the cells with protein kinase A (PKA) and protein kinase C (PKC) inhibitors, H-89 and GF109203X, respectively, attenuated the rise in luciferase.	Oxygen	0-6	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	138-154
28230075-9	2017	In OLN93 cells at 5% O2, Hif-1alpha knockdown decreased the expression of MBP and CNP, similar to that observed at 21% O2.	Oxygen	21-23	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	25-35
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	solute carrier family 2 member 3	Homo sapiens	102-108
28231331-7	2017	On the other hand, a significant enrichment in genes involved in oxygen-level response (e.g. TNFAIP3, SLC2A3, KLF6) and angiogenesis (e.g. VEGFA, IGF1, ID1) was found in the co-cultured MSCs.	Oxygen	65-71	Kruppel like factor 6	Homo sapiens	110-114
28702034-12	2017	Alternative oxidase (AOX), the terminal oxidase of the cyanide (CN)-resistant alternative respiratory pathway, catalyze oxygen-dependent oxidation of ubiquinol in plants.	Oxygen	120-126	acyl-CoA oxidase 1	Homo sapiens	0-19
28702034-12	2017	Alternative oxidase (AOX), the terminal oxidase of the cyanide (CN)-resistant alternative respiratory pathway, catalyze oxygen-dependent oxidation of ubiquinol in plants.	Oxygen	120-126	acyl-CoA oxidase 1	Homo sapiens	21-24
28630416-4	2017	We demonstrate that HIF-1 suppressed oxygen consumption and facilitated glycolysis in a pyruvate dehydrogenase kinase-1-dependent manner and that activation of HIF-1 conferred resistance to lidocaine-induced cell death.	Oxygen	37-43	pyruvate dehydrogenase kinase 1	Homo sapiens	88-119
15240394-6	2004	Oxygen reduction to 5% increased PNMT promoter-driven luciferase expression, with maximum activity at 6 h. Pretreatment of the cells with protein kinase A (PKA) and protein kinase C (PKC) inhibitors, H-89 and GF109203X, respectively, attenuated the rise in luciferase.	Oxygen	0-6	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	156-159
28129327-5	2017	In response to Htr2b activation also was evaluated the mRNA and protein levels of PGC1alpha and PPARy by RT-qPCR and western blotting and mitochondrial function by oxygen consumption rate (OCR) and ATP cellular content.	Oxygen	164-170	5-hydroxytryptamine (serotonin) receptor 2B	Mus musculus	15-20
15162502-1	2004	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a central role in regulating oxygen-dependent gene expression and is involved in a range of pathways implicated in cellular survival, proliferation, and development.	Oxygen	80-86	hypoxia-inducible factor 1-alpha-like	Xenopus laevis	0-31
28106050-0	2017	An oxygen sensitive self-decision making engineered CAR T-cell.	Oxygen	3-9	nuclear receptor subfamily 1 group I member 3	Homo sapiens	52-55
28106050-3	2017	By fusing an oxygen sensitive subdomain of HIF1alpha to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors.	Oxygen	13-19	nuclear receptor subfamily 1 group I member 3	Homo sapiens	85-88
28615633-5	2017	Most noticeably, we show that these patches induce a modulated charge distribution on the Oxygen atoms, in remarkable agreement with recent X-ray and STM observations.	Oxygen	90-96	sulfotransferase family 1A member 3	Homo sapiens	150-153
28589680-6	2017	In addition, CNTF levels were decreased in serum of retinopathy of prematurity children and in retinal tissue of oxygen-induced retinopathy mice.	Oxygen	113-119	ciliary neurotrophic factor	Homo sapiens	13-17
28106050-4	2017	Along with the development of oxygen-sensitive CAR T-cells, this work also provides a basic framework to use a multi-chain CAR as a platform to create the next generation of smarter self-decision making CAR T-cells.	Oxygen	30-36	nuclear receptor subfamily 1 group I member 3	Homo sapiens	47-50
28106050-4	2017	Along with the development of oxygen-sensitive CAR T-cells, this work also provides a basic framework to use a multi-chain CAR as a platform to create the next generation of smarter self-decision making CAR T-cells.	Oxygen	30-36	nuclear receptor subfamily 1 group I member 3	Homo sapiens	123-126
15135139-0	2004	Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.	Oxygen	66-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	84-95
28106050-4	2017	Along with the development of oxygen-sensitive CAR T-cells, this work also provides a basic framework to use a multi-chain CAR as a platform to create the next generation of smarter self-decision making CAR T-cells.	Oxygen	30-36	nuclear receptor subfamily 1 group I member 3	Homo sapiens	123-126
28326455-11	2017	Levels of O2.- and NO also showed a significant fall in case of the group treated with MMP-2 inhibitor and TNFR1 antibody both.	Oxygen	10-12	matrix metallopeptidase 2	Mus musculus	87-92
27966954-1	2017	The discovery of a novel potent type II ABL/c-KIT dual kinase inhibitor compound 34 (CHMFL-ABL/KIT-155), which utilized a hydrogen bond formed by NH on the kinase backbone and carbonyl oxygen of 34 as a unique hinge binding, is described.	Oxygen	185-191	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-43
15274434-0	2004	Polyhemoglobin-tyrosinase, an oxygen carrier with murine B16F10 melanoma suppression properties: a preliminary report.	Oxygen	30-36	tyrosinase	Mus musculus	15-25
28259531-8	2017	We present a case of unusually severe methemoglobinemia (82% methemoglobin) secondary to occupational exposure that failed to respond to several lines of management including methylene blue, red cell exchange, intravenous ascorbic acid, and hyperbaric oxygen.	Oxygen	252-258	hemoglobin subunit gamma 2	Homo sapiens	38-51
28552963-8	2017	Unlike global Bim -/- mice, mice conditionally lacking Bim in EC or PC underwent hyperoxia-mediated vessel obliteration and subsequent retinal neovascularization during oxygen-induced ischemic retinopathy similar to control littermates.	Oxygen	169-175	BCL2-like 11 (apoptosis facilitator)	Mus musculus	55-58
27450122-3	2017	It was found that the oxygen-sensing performance could be improved by optimizing the monomer ratio (MMA/TFEMA=1:1), tributylphosphate(TBP, 0.05mL) and PtOEP (5mug) content.	Oxygen	22-28	TATA-box binding protein	Homo sapiens	134-137
14764592-1	2004	The Ah receptor nuclear translocator (ARNT) is the dimeric partner of hypoxia-inducible factors and thus plays a pivotal role in cellular adaptation to low oxygen environments.	Oxygen	156-162	aryl hydrocarbon receptor nuclear translocator	Mus musculus	4-36
28585197-19	2017	Shc-generated peroxides reduce mitochondrial oxygen consumption and enhances triglyceride accumulation.	Oxygen	45-51	SHC adaptor protein 1	Homo sapiens	0-3
28589128-7	2017	Moreover, in a mouse oxygen-induced retinopathy model, specific depletion of LRP1 in endothelial cells results in abnormal development of neovessels.	Oxygen	21-27	low density lipoprotein receptor-related protein 1	Mus musculus	77-81
14764592-1	2004	The Ah receptor nuclear translocator (ARNT) is the dimeric partner of hypoxia-inducible factors and thus plays a pivotal role in cellular adaptation to low oxygen environments.	Oxygen	156-162	aryl hydrocarbon receptor nuclear translocator	Mus musculus	38-42
28407339-1	2017	For overall water-splitting systems, it is essential to establish O2 -insensitive cathodes that allow cogeneration of H2 and O2 .	Oxygen	66-68	relaxin 2	Homo sapiens	118-127
27605567-11	2017	Minor-allele absence in 2 IL10 SNPs was associated with days on oxygen ( p = .0320).	Oxygen	64-70	interleukin 10	Homo sapiens	26-30
14764593-0	2004	Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.	Oxygen	54-60	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	39-43
14764593-0	2004	Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.	Oxygen	54-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	139-144
27719648-2	2017	Interaction of AGEs with its cell-bound receptor (RAGE) results in generation of oxygen radicals, nuclear factor kappa-beta, proinflammatory cytokines and cell adhesion molecules, and is involved in the pathophysiology of cardiovascular diseases (CVD).	Oxygen	81-87	long intergenic non-protein coding RNA 914	Homo sapiens	50-54
28560010-0	2017	Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway.	Oxygen	11-17	mechanistic target of rapamycin kinase	Rattus norvegicus	99-103
28560010-4	2017	We hypothesize that hyperbaric oxygen alleviates neuropathic pain via activating autophagy flux and inhibiting mTOR pathway.	Oxygen	31-37	mechanistic target of rapamycin kinase	Rattus norvegicus	111-115
28560010-5	2017	Hyperbaric oxygen effectively inhibited nerve injury induced autophagy impairment and mTOR pathway activation in a rat spinal nerve ligation (SNL) model.	Oxygen	11-17	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
28560010-6	2017	Moreover, intrathecal injection of rapamycin, an autophagy inducer, enhanced hyperbaric oxygen effect by further decreasing mTOR activity.	Oxygen	88-94	mechanistic target of rapamycin kinase	Rattus norvegicus	124-128
28560010-8	2017	These findings indicate that hyperbaric oxygen attenuated neuropathic pain by increasing spinal autophagic flux via inhibiting mTOR pathway.	Oxygen	40-46	mechanistic target of rapamycin kinase	Rattus norvegicus	127-131
27814599-3	2017	INT6/eIF3e has recently been described as a multifunction protein playing a role in translation, protein degradation, DNA repair, nonsense-mediated mRNA decay, cell cycle and control of cell response to low oxygen (hypoxia or ischemia) through modulation of the Hypoxia Inducible Factors (HIFs).	Oxygen	207-213	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	0-4
27814599-3	2017	INT6/eIF3e has recently been described as a multifunction protein playing a role in translation, protein degradation, DNA repair, nonsense-mediated mRNA decay, cell cycle and control of cell response to low oxygen (hypoxia or ischemia) through modulation of the Hypoxia Inducible Factors (HIFs).	Oxygen	207-213	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	5-10
27982675-7	2017	Our results show that hypoxic stress induced by exposure of lower O(2) for 6 h significantly increased the levels of VEGFR-2 in skeletal muscle, heart and lung and the increases were amplified in plateau pikas.	Oxygen	66-70	kinase insert domain receptor	Homo sapiens	117-124
14981066-3	2004	This vigilant plasmid system is composed of myosin light chain-2v promoter and a gene switch that is based on an oxygen-dependent degradation domain from the hypoxia inducible factor-1-alpha.	Oxygen	113-119	hypoxia inducible factor 1, alpha subunit	Mus musculus	158-190
28082013-6	2017	The increase of methemoglobin up to 13.8% was accompanied by hypoxemia and cyanosis, necessitating additional inspired oxygen and CPAP ventilation.	Oxygen	119-125	hemoglobin subunit gamma 2	Homo sapiens	16-29
28509314-7	2017	RESULTS: CD4+CD28+ and CD8+CD28+ cells from the whole study group were characterized by shorter time required to enter the first (G1) phase of the first cell cycle at 21% compared to 10% O2.	Oxygen	187-189	CD8a molecule	Homo sapiens	23-26
28509314-13	2017	CONCLUSIONS: We showed that in vitro female T cells (both CD4+ and CD8+ cells) are more sensitive than male lymphocytes to low O2 concentration as demonstrated by the decrease in their proliferation dynamics.	Oxygen	127-129	CD8a molecule	Homo sapiens	67-70
15085064-4	2004	This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P &lt; 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P &lt; 0.03.	Oxygen	203-205	calcineurin like EF-hand protein 1	Homo sapiens	135-138
28755362-4	2017	The Cytb 558 is the membrane catalytic core of the NADPH oxidase complex, through which the reducing equivalent provided by NADPH is transferred via the associated prosthetic groups (one flavin and two hemes) to reduce dioxygen into superoxide anion.	Oxygen	219-227	mitochondrially encoded cytochrome b	Homo sapiens	4-8
28291352-1	2017	Monoamine oxidase B (MAO B) catalyzes the oxidative deamination of aryalkylamines neurotransmitters with concomitant reduction of oxygen to hydrogen peroxide.	Oxygen	130-136	monoamine oxidase B	Homo sapiens	0-19
28291352-1	2017	Monoamine oxidase B (MAO B) catalyzes the oxidative deamination of aryalkylamines neurotransmitters with concomitant reduction of oxygen to hydrogen peroxide.	Oxygen	130-136	monoamine oxidase B	Homo sapiens	21-26
27941302-5	2017	TEAD4 downregulation did not affect embryonic development until the blastocyst stage, and TEAD4-downregulated embryos were capable of forming the TE under both 5% and 21% O2 conditions.	Oxygen	171-173	TEA domain transcription factor 4	Bos taurus	90-95
28845732-3	2017	Recently, we found that hyperbaric oxygen therapy produces an antinociceptive response via the kindlin-1/wnt-10a signaling pathway in a chronic pain injury model in rats.	Oxygen	35-41	Wnt family member 10A	Rattus norvegicus	105-112
15143548-1	2004	Based on the principles of the sheet-flow model, oxygen transport in pulmonary capillaries was considered as a process in which oxygen first enters plasma through the respiratory membranes, and then combines with the Hbc.	Oxygen	49-55	keratin 88, pseudogene	Homo sapiens	217-220
28042316-2	2017	Under normoxic conditions, HIF-1alpha was degraded by oxygen-dependent prolyl hydroxylase-2 (PHD2).	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	27-37
28151660-3	2017	Despite the lack of sulfur atoms and having only oxygen-donor atoms in its structure, the best foldarand molecule, i.e., tetramer 4, exhibits a selectivity factor of at least 19 in differentiating the most tightly bound Hg2+ ion from all other metal ions, and a binding capacity that is &gt;=18 times that of thio-crown ethers.	Oxygen	49-55	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	220-223
28042316-2	2017	Under normoxic conditions, HIF-1alpha was degraded by oxygen-dependent prolyl hydroxylase-2 (PHD2).	Oxygen	54-60	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	71-91
15143548-1	2004	Based on the principles of the sheet-flow model, oxygen transport in pulmonary capillaries was considered as a process in which oxygen first enters plasma through the respiratory membranes, and then combines with the Hbc.	Oxygen	128-134	keratin 88, pseudogene	Homo sapiens	217-220
28042316-2	2017	Under normoxic conditions, HIF-1alpha was degraded by oxygen-dependent prolyl hydroxylase-2 (PHD2).	Oxygen	54-60	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	93-97
15087197-3	2004	Direct ozonation of GAC introduced large amounts of acidic surface oxygen groups, which caused a decrease in the phenol uptake.	Oxygen	67-73	glutaminase	Homo sapiens	20-23
27519633-4	2016	Low oxygen level enhanced GC proliferation with high expression levels of HIF-1, VEGF, AKT, mTOR, and S6RP, whereas addition of anti-VEGF antibody decreased cellular proliferation with low phosphorylated AKT and mTOR expression levels.	Oxygen	4-10	vascular endothelial growth factor A	Bos taurus	81-85
27707705-4	2016	We used the model to assess how changes in TNa may alter QO2 in different nephron segments and how shifting the TNa sites alters overall kidney QO2 Under baseline conditions, the model predicted a whole kidney TNa/QO2 , which denotes the number of moles of Na+ reabsorbed per moles of O2 consumed, of ~15, with TNa efficiency predicted to be significantly greater in cortical nephron segments than in medullary segments.	Oxygen	58-60	C-type lectin domain family 3, member B	Rattus norvegicus	43-46
27707706-6	2016	Under baseline conditions, NHE3, NKCC2, NCC, and ENaC reabsorb 36, 22, 4, and 7%, respectively, of filtered Na+ The model predicted that inhibition of NHE3 substantially reduced proximal tubule TNa and oxygen consumption (QO2 ).	Oxygen	202-208	solute carrier family 12 member 1	Rattus norvegicus	33-38
27988334-7	2017	In agreement with this, the expression of hypoxia induced factor-1alpha (HIF-1alpha), the master regulator of oxygen homeostasis, was significantly increased.	Oxygen	110-116	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	73-83
28469721-10	2017	IL-17 levels were positively correlated with nocturia severity (r = 0.24; P = 0.03) and negatively correlated with mean O2 saturation (r = -0.42; P = 0.03).	Oxygen	120-122	interleukin 17A	Homo sapiens	0-5
28267794-8	2017	Moreover, three of the normalized viral gene copy numbers (NS1, NS2, and N) correlated significantly with arterial O2 saturation levels.	Oxygen	115-117	influenza virus NS1A binding protein	Homo sapiens	59-62
27815261-7	2016	Deficiency or pharmacological inhibition of sEH protected mice from the LPS-induced decrease in systemic arterial oxygen concentration (PaO2 ) during LMBO.	Oxygen	114-120	epoxide hydrolase 2, cytoplasmic	Mus musculus	44-47
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	34-40	interleukin 10	Rattus norvegicus	118-123
28195739-11	2017	These findings are reminiscent of the strategy followed by several metalloproteins and highlight the possible implication of O-type species in copper-/dioxygen-dependent enzymes such as tyrosinase (Ty) and particulate methane monooxygenase (pMMO).	Oxygen	151-159	tyrosinase	Homo sapiens	186-196
28195739-11	2017	These findings are reminiscent of the strategy followed by several metalloproteins and highlight the possible implication of O-type species in copper-/dioxygen-dependent enzymes such as tyrosinase (Ty) and particulate methane monooxygenase (pMMO).	Oxygen	151-159	tyrosinase	Homo sapiens	198-200
14711797-6	2004	In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6.	Oxygen	42-44	interleukin 10	Rattus norvegicus	118-123
27747692-5	2016	The patient was treated with oxygen administration, but methemoglobin concentration was still 45 % 1 h later.	Oxygen	29-35	hemoglobin subunit gamma 2	Homo sapiens	56-69
15803717-5	2004	The immobilized Mb displays the features of a peroxidase and acts in an electrocatalytic manner in the reduction of oxygen, trichloroacetic acid (TCA), and nitrite.	Oxygen	116-122	myoglobin	Homo sapiens	16-18
28112896-8	2017	The kinetics of the conversion of O2 - to O2 and H2O2 by PEG8-PDI was measured using freeze-trap EPR experiments to provide a turnover number of 133 s-1; the similarity in kinetics further supports that PEG8-PDI is a true SOD mimetic.	Oxygen	34-36	IGF2 antisense RNA	Homo sapiens	57-61
28112896-8	2017	The kinetics of the conversion of O2 - to O2 and H2O2 by PEG8-PDI was measured using freeze-trap EPR experiments to provide a turnover number of 133 s-1; the similarity in kinetics further supports that PEG8-PDI is a true SOD mimetic.	Oxygen	34-36	IGF2 antisense RNA	Homo sapiens	203-207
28112896-8	2017	The kinetics of the conversion of O2 - to O2 and H2O2 by PEG8-PDI was measured using freeze-trap EPR experiments to provide a turnover number of 133 s-1; the similarity in kinetics further supports that PEG8-PDI is a true SOD mimetic.	Oxygen	42-44	IGF2 antisense RNA	Homo sapiens	57-61
26785288-0	2016	PLC-beta2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.	Oxygen	30-36	phospholipase C beta 2	Homo sapiens	0-9
28112896-8	2017	The kinetics of the conversion of O2 - to O2 and H2O2 by PEG8-PDI was measured using freeze-trap EPR experiments to provide a turnover number of 133 s-1; the similarity in kinetics further supports that PEG8-PDI is a true SOD mimetic.	Oxygen	42-44	IGF2 antisense RNA	Homo sapiens	203-207
26785288-3	2016	Here we report that hypoxia modulates the expression of PLC-beta2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability.	Oxygen	273-279	phospholipase C beta 2	Homo sapiens	56-65
14738455-7	2004	Of the clinical parameters tested, minimal oxygen saturation was found to correlate negatively with this expression in the group of infants with increased TLR4.	Oxygen	43-49	toll like receptor 4	Homo sapiens	155-159
26785288-5	2016	The increase of PLC-beta2 induced by low oxygen in MDA-MB-231 cells supports the hypoxia-related reorganization of actin cytoskeleton and sustains invasion capability.	Oxygen	41-47	phospholipase C beta 2	Homo sapiens	16-25
26785288-7	2016	Our data include PLC-beta2 in the complex and interconnected signaling pathways induced by low oxygen availability in breast tumor cells and suggest that the forced modulation of PLC-beta2 programmed on the basis of tumor phenotype may prevent the malignant progression of breast neoplasia as a consequence of intra-tumoral hypoxia.	Oxygen	95-101	phospholipase C beta 2	Homo sapiens	17-26
26785288-7	2016	Our data include PLC-beta2 in the complex and interconnected signaling pathways induced by low oxygen availability in breast tumor cells and suggest that the forced modulation of PLC-beta2 programmed on the basis of tumor phenotype may prevent the malignant progression of breast neoplasia as a consequence of intra-tumoral hypoxia.	Oxygen	95-101	phospholipase C beta 2	Homo sapiens	179-188
27772541-6	2017	After treatment with BM-MSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by upregulating protein kinase B/mammalian target of rapamycin (AKT/mTOR) expression in an oxygen- and glucose-deprived (OGD) environment.	Oxygen	192-198	brain derived neurotrophic factor	Homo sapiens	96-100
14643885-2	2004	These include transcriptional responses to environmental pollutants and low oxygen tension, mediated by the aryl hydrocarbon (Dioxin) receptor and hypoxia inducible factors (HIF), respectively, and controlling aspects of neural development, mediated by the single minded (SIM) proteins.	Oxygen	76-82	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	174-177
27840375-8	2017	Echinomycin, a small-molecule inhibitor of HIF-1"s DNA-binding activity, attenuated the effects of CoCl2 and of low oxygen tension (10% O2) on P4 production and StAR expression in luteinizing GCs.	Oxygen	116-122	hypoxia inducible factor 1 subunit alpha	Bos taurus	43-48
27840375-8	2017	Echinomycin, a small-molecule inhibitor of HIF-1"s DNA-binding activity, attenuated the effects of CoCl2 and of low oxygen tension (10% O2) on P4 production and StAR expression in luteinizing GCs.	Oxygen	136-138	hypoxia inducible factor 1 subunit alpha	Bos taurus	43-48
28144654-0	2017	The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.	Oxygen	35-37	lysine demethylase 4A	Homo sapiens	86-91
28144654-0	2017	The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.	Oxygen	35-37	lysine demethylase 4A	Homo sapiens	92-98
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	36-38	lysine demethylase 4A	Homo sapiens	137-142
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	36-38	lysine demethylase 4A	Homo sapiens	143-149
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	131-133	lysine demethylase 4A	Homo sapiens	137-142
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	131-133	lysine demethylase 4A	Homo sapiens	143-149
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	131-133	lysine demethylase 4A	Homo sapiens	137-142
28144654-1	2017	JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.	Oxygen	131-133	lysine demethylase 4A	Homo sapiens	143-149
27830987-2	2016	AOX acts as a means to relax the highly coupled and tensed electron transport process in mitochondria thus providing and maintaining the much needed metabolic homeostasis by directly reducing oxygen to water.	Oxygen	192-198	acyl-CoA oxidase 1	Homo sapiens	0-3
27933832-4	2016	Advanced thin film EDX analysis showed that during the annealing process predominantly oxygen is released from the Co-C-O deposits, yielding an atomic ratio of Co:C:O = 100:16:1 (85:14:1) with respect to the atomic composition of as-written Co:C:O = 100:21:28 (67:14:19).	Oxygen	87-93	DAN domain BMP antagonist family member 5	Homo sapiens	115-121
27942238-8	2016	RESULTS: Coincubation of complexed mitochondria and AsOR-LLO with Huh7-Mito- cells increased mitochondrial DNA to &gt;9,700-fold over control at 7 days (P&lt;0.001), and increased mitochondrial oxygen-consumption rates to &gt;90% of control by 10 days.	Oxygen	194-200	MIR7-3 host gene	Homo sapiens	66-70
27694440-4	2016	TRPM2-depleted SH-SY5Y neuroblastoma cells demonstrated reduced oxygen consumption and ATP production after doxorubicin, confirming impaired cellular bioenergetics.	Oxygen	64-70	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
28208270-6	2017	Cyclic voltammetry and amperometry demonstrate excellent electrocatalytic activity toward oxygen reduction in addition to a high sensitivity (-0.16 +- 0.02 nA muM-1) and a low limit of detection (0.33 +- 0.20 muM).	Oxygen	90-96	PWWP domain containing 3A, DNA repair factor	Rattus norvegicus	159-164
15013368-8	2004	PCNA immunocytochemistry confirmed decreasing fractions of proliferating cells as a function of distance from oxygen and metabolites.	Oxygen	110-116	proliferating cell nuclear antigen	Homo sapiens	0-4
28115711-3	2017	Here, we propose that a metastable radical state, nonreactive with oxygen, safely holds electrons at a local energetic minimum during the oxidation of plastohydroquinone catalyzed by the chloroplast cytochrome b6f This intermediate state is formed by interaction of a radical with a metal cofactor of a catalytic site.	Oxygen	67-73	mitochondrially encoded cytochrome b	Homo sapiens	199-211
28161055-11	2017	In isolated primary trophoblasts, HSP70 and HO-1 were upregulated by increasing oxygen tension, but not by hyperglycemia or TNF-alpha.	Oxygen	80-86	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
27662906-8	2016	A lack of Rcf2 and Rcf3 increases oxygen flux through the respiratory chain by up-regulation of the cytochrome c oxidase activity.	Oxygen	34-40	Rcf2p	Saccharomyces cerevisiae S288C	10-14
27814710-1	2016	BACKGROUND: Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues.	Oxygen	118-124	hemoglobin subunit gamma 2	Homo sapiens	76-89
27814710-1	2016	BACKGROUND: Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues.	Oxygen	118-124	hemoglobin subunit gamma 2	Homo sapiens	91-94
14728720-14	2004	CONCLUSIONS: The results suggest that circulating endostatin can be significantly increased by exercise in proportion to the peak oxygen consumption under physiological conditions in healthy volunteers.	Oxygen	130-136	collagen type XVIII alpha 1 chain	Homo sapiens	50-60
27812217-6	2016	Overexpression of NTR2 in wild-type parasites rendered cells hyper-sensitive to bicyclic nitro-compounds, but only marginally to the monocyclic nitro-drugs, nifurtimox and fexinidazole sulfone, known to be activated by a mitochondrial oxygen-insensitive nitroreductase (NTR1).	Oxygen	235-241	neurotensin receptor 2	Homo sapiens	18-22
27805294-5	2017	Furthermore, we can distinctly observe that the introduction of oxygen vacancies narrows the hybridization orbital between O 2p and Co 3d and optimizes the O p-band center near the Fermi level by X-ray absorption spectroscopy, which greatly improves the catalytic activity of CO oxidation and photocatalytic water splitting.	Oxygen	64-70	immunoglobulin kappa variable 1D-39	Homo sapiens	123-127
15356757-7	2004	The extent by which the amide cleavage reaction is accelerated in 1-3 relative to the free ligands, L1-3, is correlated with the strength of amide oxygen binding and Lewis acidity of the zinc(II) centre in deduced from the X-ray, NMR and IR studies.	Oxygen	147-153	immunoglobulin kappa variable 2-4 (pseudogene)	Homo sapiens	100-104
28098753-6	2017	Lactate oxidase (LOx) catalyzes the conversion of l-lactate to pyruvate in the presence of oxygen, producing hydrogen peroxide, which is catalytically oxidized at 3,4DHS-AuNPs modified screen-printed carbon electrodes at +0.2 V. The measured electrocatalytic current is directly proportional to the concentration of peroxide, which is related to the amount of lactate present in the sample.	Oxygen	91-97	lysyl oxidase	Homo sapiens	0-15
28098753-6	2017	Lactate oxidase (LOx) catalyzes the conversion of l-lactate to pyruvate in the presence of oxygen, producing hydrogen peroxide, which is catalytically oxidized at 3,4DHS-AuNPs modified screen-printed carbon electrodes at +0.2 V. The measured electrocatalytic current is directly proportional to the concentration of peroxide, which is related to the amount of lactate present in the sample.	Oxygen	91-97	lysyl oxidase	Homo sapiens	17-20
26606199-4	2016	CD8+ effector T cells are less dependent on Glut1 and oxygen levels compared to their CD4+ counterparts.	Oxygen	54-60	CD8a molecule	Homo sapiens	0-3
26753753-0	2016	Mechanism of p47phox-induced increase of reactive oxygen species in peripheral blood mononuclear cells from premature infants on oxygen therapy.	Oxygen	50-56	neutrophil cytosolic factor 1	Homo sapiens	13-20
26753753-1	2016	OBJECTIVE: This study aimed to explore the mechanism of p47phox-induced increase of reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) from premature infants after oxygen therapy, and determine a new target for oxidative stress injury alleviation in clinical setting.	Oxygen	93-99	neutrophil cytosolic factor 1	Homo sapiens	56-63
26753753-5	2016	In agreement, PBMCs cultured in vitro showed increased ROS levels after treatment with high oxygen concentrations; p47phox translocation, and expression increased as well (p &lt; 0.05).	Oxygen	92-98	neutrophil cytosolic factor 1	Homo sapiens	115-122
26753753-7	2016	CONCLUSION: Treatment with oxygen increases p47phox translocationand expression, which in turn induce ROS production.	Oxygen	27-33	neutrophil cytosolic factor 1	Homo sapiens	44-51
27792771-5	2016	Chemerin protein levels increased after 4 h of hypoxia at 2.5% O2, with a peak of expression of tumor necrosis factor-alpha (TNF-alpha) at 1 h. Both hypoxia and exogenously added TNF-alpha during normoxia stimulated chemerin expression, whereas an ERK inhibitor (PD98059), ERK small interfering RNA (siRNA), or an anti-TNF-alpha antibody attenuated the chemerin upregulation induced by hypoxia.	Oxygen	63-65	retinoic acid receptor responder 2	Homo sapiens	0-8
28138246-9	2017	In the DM1 group, the median SNAP and the distal motor latency (DML) of the ulnar nerve correlated with the apnea-hypopnea index, while the oxygen desaturation index correlated with the DML of the tibial nerve and with conduction velocity in the sural nerve.	Oxygen	140-146	DM1 protein kinase	Homo sapiens	7-10
28105019-2	2016	BOLD-MRI uses the fact that magnetic properties of hemoglobin depend of its oxygenated state:: the higher local deoxyhemoglobin, the higher the so called apparent relaxation rate R2* (sec-1), and the lower local tissue oxygen content.	Oxygen	76-82	secretory blood group 1, pseudogene	Homo sapiens	184-189
27800026-7	2016	In agreement with the global increase of H3K27 trimethylation, we provide direct evidence that the histone H3K27me3 demethylase KDM6B/JMJD3 is inactivated by limited oxygen.	Oxygen	166-172	lysine demethylase 6B	Homo sapiens	128-133
14690739-3	2004	It has been shown that, after 16 min normothermic ischemia followed by 3.3-h hypothermic preservation, excellent myocardial and cardiovascular recovery is attained, if coronary oxygen persufflation (COP) is included in the preservation protocol.	Oxygen	177-183	caspase recruitment domain family member 16	Homo sapiens	199-202
27800026-7	2016	In agreement with the global increase of H3K27 trimethylation, we provide direct evidence that the histone H3K27me3 demethylase KDM6B/JMJD3 is inactivated by limited oxygen.	Oxygen	166-172	lysine demethylase 6B	Homo sapiens	134-139
27133447-8	2017	Pulmonary artery systolic and mean pressures decreased from 79 to 67 mmHg and from 59 to 50 mmHg, respectively (p25% (both in oxygen) (p=0.007).	Oxygen	126-132	tubulin polymerization promoting protein	Homo sapiens	112-116
27725654-6	2016	This finding illustrates a crucial role of oxidation in the spin Hall effect, opening a route for engineering the spin-torque generator by oxygen control and manipulating magnetization without using heavy metals.	Oxygen	139-145	spindlin 1	Homo sapiens	60-64
14707731-3	2004	Acinar cell apoptosis is triggered by oxygen deprivation, ie, hypoxia, by activation of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	38-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-119
27725654-6	2016	This finding illustrates a crucial role of oxidation in the spin Hall effect, opening a route for engineering the spin-torque generator by oxygen control and manipulating magnetization without using heavy metals.	Oxygen	139-145	spindlin 1	Homo sapiens	114-118
27626932-0	2016	Photochemical Synthesis of Carbazoles Using an [Fe(phen)3](NTf2)2/O2 Catalyst System: Catalysis toward Sustainability.	Oxygen	66-68	nuclear transport factor 2	Homo sapiens	59-63
28029689-3	2017	Hyd-1 and Hyd-5 are homologous oxygen-tolerant [NiFe]-hydrogenases.	Oxygen	31-37	msh homeobox 1	Homo sapiens	0-5
14707731-3	2004	Acinar cell apoptosis is triggered by oxygen deprivation, ie, hypoxia, by activation of hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	38-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-131
27626932-1	2016	An increasingly sustainable photochemical synthesis of carbazoles was developed using a catalytic system of Fe(phen)3(NTf2)2/O2 under continuous flow conditions and was demonstrated on gram-scale using a numbering-up strategy.	Oxygen	125-127	nuclear transport factor 2	Homo sapiens	118-122
28869464-3	2017	Oxygen deprivation (OD) resulted in tau dephosphorylation at several AD-related residues and activation of GSK3beta and phosphatase PP2A.	Oxygen	0-6	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	132-136
15342936-1	2004	In the present work, we tested the hypothesis that liquid cultures (LCs) of cord blood CD34+ cells at an appropriate low O2 concentration could simultaneously allow colony-forming cell (CFC) expansion and nonobese diabetic/severe combined immunodeficiency mice-repopulating cell (SRC) maintenance.	Oxygen	121-123	CD34 antigen	Mus musculus	87-91
27421179-4	2016	Here, we report a small-molecular inhibitor of nNOS-PSD-95 interaction, SCR-4026, which exhibits neuroprotective activities in NMDA-induced or Oxygen and glucose deprivation (OGD)-induced neuronal damage in primary cortical neurons cultures, and ameliorated focal cerebral ischemic damage in rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion.	Oxygen	143-149	nitric oxide synthase 1	Rattus norvegicus	47-51
30802390-15	2017	The second one - a gene of uricase "minus" blocked synthesis of allantoin but provided a possibility of re-absorbing uric acid from a pool of primary urine and use it in vivo as an acceptor of active forms of oxygen instead of ascorbic acid under realization of biological function of endoecology,biologic reaction of inflammation.	Oxygen	209-215	urate oxidase (pseudogene)	Homo sapiens	27-34
14658865-18	2003	The sulfoximido complex trans-[OsIV(tpy)(Cl)2(NS(O)-p-C6H4Me)] undergoes loss of O2 with added acid and O-atom transfer to trans-stilbene and PPh3.	Oxygen	81-83	protein phosphatase 4 catalytic subunit	Homo sapiens	142-146
29147462-0	2017	Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-kappaB Pathways.	Oxygen	0-6	NADPH oxidase 4	Rattus norvegicus	15-19
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	Oxygen	33-35	KRAS proto-oncogene, GTPase	Rattus norvegicus	77-80
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	Oxygen	33-35	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	88-91
29147462-7	2017	Furthermore, 20% O2 was found to upregulate Nox4 in NP cells.	Oxygen	17-19	NADPH oxidase 4	Rattus norvegicus	44-48
26251187-2	2016	To prevent this risk of infection, cellobiose dehydrogenase (CDH), an antimicrobial enzyme able to use various oligosaccharides as electron donors to produce hydrogen peroxide using oxygen as an electron acceptor, was covalently grafted onto plasma-activated urinary polydimethylsiloxane (PDMS) catheter surfaces.	Oxygen	182-188	choline dehydrogenase	Homo sapiens	35-59
26251187-2	2016	To prevent this risk of infection, cellobiose dehydrogenase (CDH), an antimicrobial enzyme able to use various oligosaccharides as electron donors to produce hydrogen peroxide using oxygen as an electron acceptor, was covalently grafted onto plasma-activated urinary polydimethylsiloxane (PDMS) catheter surfaces.	Oxygen	182-188	choline dehydrogenase	Homo sapiens	61-64
27802588-7	2016	The Hbb and Hba, genes with oxygen transport and antioxidant functions, were increased on days 1 and 14.	Oxygen	28-34	hemoglobin beta chain complex	Mus musculus	4-7
27684068-10	2016	Accordingly, oxygen consumption was increased in the brown adipocytes from IL-15 KO mice.	Oxygen	13-19	interleukin 15	Mus musculus	75-80
29387292-0	2017	Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.	Oxygen	20-26	serpin family A member 4	Homo sapiens	65-76
29387292-0	2017	Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.	Oxygen	100-106	serpin family A member 4	Homo sapiens	41-52
29387292-0	2017	Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.	Oxygen	100-106	serpin family A member 4	Homo sapiens	65-76
29387292-7	2017	High oxygen inhibits kallistatin expression via activating the JNK-FOXO1 pathway in endothelial cells.	Oxygen	5-11	serpin family A member 4	Homo sapiens	21-32
29387292-7	2017	High oxygen inhibits kallistatin expression via activating the JNK-FOXO1 pathway in endothelial cells.	Oxygen	5-11	mitogen-activated protein kinase 8	Mus musculus	63-72
29387292-8	2017	Conversely, mild oxygen/hyperoxia stimulates kallistatin, eNOS, and hypoxia-inducible factor-1 (HIF-1) expression in endothelial cells and in the kidney of normal mice.	Oxygen	17-23	serpin family A member 4	Homo sapiens	45-56
29387292-9	2017	Likewise, kallistatin stimulates eNOS and HIF-1, and kallistatin antisense RNA abolishes oxygen-induced eNOS and HIF-1 expression, indicating a role of kallistatin in mediating mild oxygen"s stimulation on antioxidant genes.	Oxygen	89-95	serpin family A member 4	Homo sapiens	53-64
29387292-9	2017	Likewise, kallistatin stimulates eNOS and HIF-1, and kallistatin antisense RNA abolishes oxygen-induced eNOS and HIF-1 expression, indicating a role of kallistatin in mediating mild oxygen"s stimulation on antioxidant genes.	Oxygen	89-95	serpin family A member 4	Homo sapiens	53-64
29387292-9	2017	Likewise, kallistatin stimulates eNOS and HIF-1, and kallistatin antisense RNA abolishes oxygen-induced eNOS and HIF-1 expression, indicating a role of kallistatin in mediating mild oxygen"s stimulation on antioxidant genes.	Oxygen	182-188	serpin family A member 4	Homo sapiens	53-64
14658876-7	2003	In the presence of excess vinyltrimethylsilane (vtms), Ag2O and Hhfac form [Ag3(hfac)3(vtms)]infinity, 4, which contains trimetallic subunits assembled via oxygen atoms of bridging hfac ligands and 5- and 6-coordinate silver.	Oxygen	156-162	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	55-58
28123871-2	2016	Recent studies highlighting the importance of O2 and hypoxia-inducible factors for CD8+ T-cell function and fate must now be integrated into tumor immunology concepts if immunotherapies are to progress.	Oxygen	46-48	CD8a molecule	Homo sapiens	83-86
28123871-3	2016	Here, we discuss, reinterpret, and reconcile the many apparent contradictions in these data and we propose that O2 is a master regulator of the CD8+ T-cell response.	Oxygen	112-114	CD8a molecule	Homo sapiens	144-147
14632752-6	2003	We have found that stimulation with leptin produces oxygen radical formation by monocytes.	Oxygen	52-58	leptin	Homo sapiens	36-42
27525436-4	2016	FYN and NOX4 colocalized in perinuclear mitochondria, ER, and nuclear fractions in CMs, and FYN expression negatively regulated NOX4-induced O2- production and apoptosis in CMs.	Oxygen	141-143	Fyn proto-oncogene	Mus musculus	92-95
27990811-5	2016	The variations of elastic constants C11 and C44 as a function of Na2O mol % are discussed and correlated to structural results and potential energies of oxygen atoms.	Oxygen	153-159	RNA polymerase III subunit K	Homo sapiens	36-39
14636286-10	2003	Iron used in vitro at concentration 0.0001 mg mL-1 and greater induces generation of oxygen-derived free radicals in mesothelial cells.	Oxygen	85-91	L1 cell adhesion molecule	Mus musculus	46-50
27924994-1	2016	In contrast to the general tendency that six coordinate iron(iii) porphyrin complexes with neutral oxygen ligands adopt a high-spin state in a wide range of temperature, some complexes with substituted pyridine N-oxides have exhibited spin-crossover from high-spin to low-spin states with decreasing temperature both in solution and in the solid state.	Oxygen	99-105	spindlin 1	Homo sapiens	127-131
27385725-1	2016	STUDY QUESTION: Do high oxygen tension and high glucose concentrations dysregulate p66Shc (Src homologous-collagen homologue adaptor protein) expression during mouse preimplantation embryo culture?	Oxygen	24-30	src homology 2 domain-containing transforming protein C1	Mus musculus	83-89
27385725-2	2016	SUMMARY ANSWER: Compared with mouse blastocysts in vivo, P66Shc mRNA and protein levels in blastocysts maintained in vitro increased under high oxygen tension (21%), but not high glucose concentration.	Oxygen	144-150	src homology 2 domain-containing transforming protein C1	Mus musculus	57-63
27852045-2	2016	We previously showed that BCR/Abl protein is suppressed in low oxygen, where viable cells retain stem cell potential.	Oxygen	63-69	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-33
14614042-10	2003	These findings indicate that CP-M is a differentiation-related molecule for human EVT and suggest that CP-M expression on EVT is partially regulated by tissue oxygen concentration.	Oxygen	159-165	carboxypeptidase M	Homo sapiens	29-33
27852045-3	2016	This study addressed the regulation of BCR/Abl protein expression under oxygen or glucose shortage, characteristic of the in vivo environment where cells resistant to tyrosine kinase inhibitors (TKi) persist.	Oxygen	72-78	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	39-46
27852045-5	2016	BCR/abl mRNA steady-state analysis and ChIP-qPCR on BCR promoter revealed that BCR/abl transcriptional activity is reduced in K562 cells under oxygen shortage.	Oxygen	143-149	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
14614042-10	2003	These findings indicate that CP-M is a differentiation-related molecule for human EVT and suggest that CP-M expression on EVT is partially regulated by tissue oxygen concentration.	Oxygen	159-165	carboxypeptidase M	Homo sapiens	103-107
27852045-5	2016	BCR/abl mRNA steady-state analysis and ChIP-qPCR on BCR promoter revealed that BCR/abl transcriptional activity is reduced in K562 cells under oxygen shortage.	Oxygen	143-149	BCR activator of RhoGEF and GTPase	Homo sapiens	0-3
27852045-5	2016	BCR/abl mRNA steady-state analysis and ChIP-qPCR on BCR promoter revealed that BCR/abl transcriptional activity is reduced in K562 cells under oxygen shortage.	Oxygen	143-149	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	79-86
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	38-44	DNA damage inducible transcript 4	Homo sapiens	124-129
27577706-4	2016	RESULTS: Exposure of BeWo cells to 1% oxygen (compared with 21% oxygen) led to a remarkable increase of both HIF-1alpha and REDD1 and an obvious decrease of mTOR at both the mRNA and protein levels.	Oxygen	64-70	DNA damage inducible transcript 4	Homo sapiens	124-129
27852045-7	2016	However, only low oxygen decreased polysome-associated BCR/abl mRNA significantly in KCL22 cells, suggesting a decreased BCR/Abl translation.	Oxygen	18-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-62
27577710-0	2016	Low oxygen tension induces Kruppel-Like Factor 6 expression in trophoblast cells.	Oxygen	4-10	Kruppel like factor 6	Homo sapiens	27-48
27577710-3	2016	While oxygen is a critical mediator of trophoblast differentiation and function, the involvement of oxygen in the regulation of KLF6 expression remains unexplored.	Oxygen	100-106	Kruppel like factor 6	Homo sapiens	128-132
27577710-12	2016	The regulation of KLF6 protein levels by oxygen has significant implications for understanding its putative role in diseases affected by tissue hypoxia.	Oxygen	41-47	Kruppel like factor 6	Homo sapiens	18-22
27852045-7	2016	However, only low oxygen decreased polysome-associated BCR/abl mRNA significantly in KCL22 cells, suggesting a decreased BCR/Abl translation.	Oxygen	18-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	121-128
27852045-8	2016	The proteasome inhibitor MG132 or the pan-caspase inhibitor z-VAD-fmk extended BCR/Abl expression under oxygen/glucose shortage in K562 cells.	Oxygen	104-110	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	79-86
27995963-7	2016	Knockout of Ogg1 in detrusor cells resulted in accumulation of reactive oxygen mediated 8-Oxo-dG and spontaneous pyroptotic signaling.	Oxygen	72-78	8-oxoguanine DNA-glycosylase 1	Mus musculus	12-16
26838608-7	2016	The reduction of chemical oxygen demand (COD) in FB 1 was primarily due to flushing.	Oxygen	26-32	TCF3 fusion partner	Homo sapiens	49-53
14623274-8	2003	NMU-induced increases in oxygen consumption and body temperature were attenuated in CRH KO mice.	Oxygen	25-31	neuromedin U	Mus musculus	0-3
27486831-2	2016	These structures often differ at the C3a position, which may be substituted with an oxygen, nitrogen, or sp(3)- or sp(2)-hybridized carbon.	Oxygen	84-90	endogenous retrovirus group K member 2	Homo sapiens	37-40
27512952-7	2016	Most importantly, the mutant phenotype of IDS-ko astrocytes was reversed by low oxygen conditions and treatment with vitamin E, which also reversed the toxic effect on cocultured neurons.	Oxygen	80-86	iduronate 2-sulfatase	Homo sapiens	42-45
27449104-0	2016	NADPH: new oxygen for the ROS theory of aging.	Oxygen	11-17	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
27404666-2	2016	The C-3 stereogenic center is subsequently exploited to create the C-1 stereocenter by coordination of the nucleophilic reagent to the oxygen atom of oxazolidine.	Oxygen	135-141	complement C3	Homo sapiens	4-7
27400126-6	2016	In brain slice explants, oxygen deprivation (OD) activated apoptotic pathways and increased neuronal cell death in IL-21 receptor-deficient (IL-21R-deficient) mice compared with control animals.	Oxygen	25-31	interleukin 21 receptor	Mus musculus	115-129
27400126-6	2016	In brain slice explants, oxygen deprivation (OD) activated apoptotic pathways and increased neuronal cell death in IL-21 receptor-deficient (IL-21R-deficient) mice compared with control animals.	Oxygen	25-31	interleukin 21 receptor	Mus musculus	141-147
26024288-2	2016	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) is the PAM domain responsible for the copper-, ascorbate- and O2-dependent hydroxylation of a glycine-extended peptide.	Oxygen	118-120	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	0-49
26024288-2	2016	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) is the PAM domain responsible for the copper-, ascorbate- and O2-dependent hydroxylation of a glycine-extended peptide.	Oxygen	118-120	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
26024288-2	2016	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) is the PAM domain responsible for the copper-, ascorbate- and O2-dependent hydroxylation of a glycine-extended peptide.	Oxygen	118-120	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	63-66
27038237-0	2016	Adaptive responses of outer membrane porin balance of Yersinia ruckeri under different incubation temperature, osmolarity, and oxygen availability.	Oxygen	127-133	DNA uptake porin HofQ	Yersinia ruckeri	37-42
27038237-6	2016	The limitation of oxygen availability led to decreased expression of both major porins and increased transcription of the minor porin OmpY.	Oxygen	18-24	DNA uptake porin HofQ	Yersinia ruckeri	80-85
27072164-1	2016	Tryptophan-2, 3-dioxygenase (TDO) is a heme-containing protein catalyzing the first reaction in the kynurenine pathway, which incorporates oxygen into the indole moiety of tryptophan and catalyzes it into kynurenine (KYN).	Oxygen	18-24	tryptophan 2,3-dioxygenase	Homo sapiens	29-32
27348090-2	2016	Prior study of related halogenases forecasts substrate hydroxylation in this active-site configuration, but X-ray crystallographic verification of C13 halogenation in single crystals mandates that ligand dynamics must reposition the oxygen ligand to enable the observed outcome.	Oxygen	233-239	homeobox C13	Homo sapiens	147-150
27165422-6	2016	Likewise, oxygen pulse, maximal work load, and ventilatory threshold were also lower in NAC+ subjects, whereas peak heart rate and breathing reserve were similar.	Oxygen	10-16	X-linked Kx blood group	Homo sapiens	88-91
27517780-2	2016	We demonstrate that the previous assignment of the dark objects in STM to chemisorbed oxygen atoms is incorrect and incompatible with trefoil-like structures observed in atomic-resolution images in current work.	Oxygen	86-92	sulfotransferase family 1A member 3	Homo sapiens	67-70
27327106-1	2016	The spin-crossing mechanism of oxygen dissociation on Ag20 and monodoped Ag19Au clusters was investigated via spin-polarized scalar-relativistic DFT calculations using the PBE, TPSSh, M06L, mPBE, BLYP, OLYP, and B3LYP functionals.	Oxygen	31-37	spindlin 1	Homo sapiens	4-8
27327106-1	2016	The spin-crossing mechanism of oxygen dissociation on Ag20 and monodoped Ag19Au clusters was investigated via spin-polarized scalar-relativistic DFT calculations using the PBE, TPSSh, M06L, mPBE, BLYP, OLYP, and B3LYP functionals.	Oxygen	31-37	spindlin 1	Homo sapiens	110-114
27135698-6	2016	The biomolecular k values for reaction of (1)O2 and OH with BDE-153 were 3.65 x 10(6) and 7.70 x 10(8) M(-1) s(-1), respectively.	Oxygen	42-47	homeobox D13	Homo sapiens	60-63
27135698-7	2016	The contribution of OH (28.7-31.0%) to the indirect photolysis of BDE-153 was higher than for (1)O2 (12.9-14.9%).	Oxygen	97-99	homeobox D13	Homo sapiens	66-69
27135698-8	2016	The photolytic rate of BDE-153 in oxygen-rich (aerated) solution was much slower than in oxygen-poor (nitrogen-sparged) conditions, demonstrating that (3)NOM* is a more effective reagent for degradation of BDE-153 than (1)O2.	Oxygen	34-40	homeobox D13	Homo sapiens	23-26
27135698-8	2016	The photolytic rate of BDE-153 in oxygen-rich (aerated) solution was much slower than in oxygen-poor (nitrogen-sparged) conditions, demonstrating that (3)NOM* is a more effective reagent for degradation of BDE-153 than (1)O2.	Oxygen	34-40	homeobox D13	Homo sapiens	206-209
27135698-8	2016	The photolytic rate of BDE-153 in oxygen-rich (aerated) solution was much slower than in oxygen-poor (nitrogen-sparged) conditions, demonstrating that (3)NOM* is a more effective reagent for degradation of BDE-153 than (1)O2.	Oxygen	89-95	homeobox D13	Homo sapiens	23-26
27007876-11	2016	Compared with gene expression levels at 5 % O2, which were arbitrarily set as "1," 20 % O2 is associated with significantly higher expression of BAX (2.14 +- 0.47), G6PD (2.92 +- 1.06), MnSOD (2.87 +- 0.88), and HSP70.1 (8.68 +- 4.19).	Oxygen	44-46	glucose-6-phosphate dehydrogenase	Homo sapiens	165-169
27007876-11	2016	Compared with gene expression levels at 5 % O2, which were arbitrarily set as "1," 20 % O2 is associated with significantly higher expression of BAX (2.14 +- 0.47), G6PD (2.92 +- 1.06), MnSOD (2.87 +- 0.88), and HSP70.1 (8.68 +- 4.19).	Oxygen	88-90	glucose-6-phosphate dehydrogenase	Homo sapiens	165-169
27210229-3	2016	A modified combining rule with rescaled effective cross-interaction radius between cations and the hydroxyl oxygens on the carbohydrates was introduced to reproduce the experimental stability constants, which the preferential carbohydrate-cation complexing structures through the ax-eq-ax sequence of O-1, O-2, and O-3 on alpha-d-Allopyranose were also observed.	Oxygen	108-115	immunoglobulin kappa variable 2D-40	Homo sapiens	301-318
26941203-7	2016	Deregulation of p66(Shc) and JunD in aged EOCs led to up-regulation of NADPH oxidase, reduced expression of manganese superoxide dismutase (MnSOD) and increased O2 (-) generation.	Oxygen	161-163	SHC adaptor protein 1	Homo sapiens	20-23
27090063-5	2016	To be specific, chondrogenic maker genes: AGC, COL II and SOX9 were remarkably enhanced in both ASCs and chondrocytes after crosstalk under low oxygen tension.	Oxygen	144-150	SRY-box transcription factor 9	Rattus norvegicus	58-62
26922365-8	2016	RESULTS: We found that miR-150 expression in the brain and serum of rats subjected to cerebral ischemia, and in oxygen-glucose-deprived brain microvascular endothelial cells (BMVECs) and astrocytes.	Oxygen	112-118	microRNA 150	Rattus norvegicus	23-30
26935109-6	2016	Clamp studies revealed that POMC-Ptp1b deletion reduced body fat and increased energy expenditure as evidenced by a decrease in feed efficiency and an increase in oxygen consumption and respiratory exchange ratio.	Oxygen	163-169	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	33-38
26646457-0	2016	Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation Through Reactive Oxygen Species/Thioredoxin-Interacting Protein/Nod-Like Receptor Protein 3 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats.	Oxygen	11-17	thioredoxin interacting protein	Rattus norvegicus	104-135
26646457-13	2016	The benefits of hyperbaric oxygen preconditioning on hyperglycemic middle cerebral artery occlusion rats were reversed after blocking the reactive oxygen species/thioredoxin-interacting protein/Nod-like receptor protein 3 pathway.	Oxygen	27-33	thioredoxin interacting protein	Rattus norvegicus	162-193
26646457-15	2016	Hyperbaric oxygen preconditioning attenuated hemorrhagic transformation through reactive oxygen species/thioredoxin-interacting protein/Nod-like receptor protein 3 pathway.	Oxygen	11-17	thioredoxin interacting protein	Rattus norvegicus	104-135
26602869-0	2016	Effect of microtubule-associated protein-4 on epidermal cell migration under different oxygen concentrations.	Oxygen	87-93	microtubule associated protein 4	Homo sapiens	10-42
26602869-4	2016	MAP4"s effect on cell migration under different oxygen concentrations was also studied.	Oxygen	48-54	microtubule associated protein 4	Homo sapiens	0-4
26602869-6	2016	On the other hand, MAP4 silencing through targeted shRNA attenuated HaCaT cell migration under the above oxygen concentrations.	Oxygen	105-111	microtubule associated protein 4	Homo sapiens	19-23
26602869-7	2016	These results imply that MAP4 plays an important role in epidermal cell migration under different oxygen concentrations.	Oxygen	98-104	microtubule associated protein 4	Homo sapiens	25-29
27252251-1	2016	Dietary fish oil-derived n-3 PUFA supplementation can increase muscle mass, reduce oxygen demand during physical activity, and improve physical function (muscle strength and power, and endurance) in people.	Oxygen	83-89	pumilio RNA binding family member 3	Homo sapiens	29-33
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	hepatocyte growth factor	Mus musculus	153-177
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	hepatocyte growth factor	Mus musculus	179-182
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	vascular endothelial growth factor A	Mus musculus	189-223
27102647-6	2016	Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF).	Oxygen	12-14	vascular endothelial growth factor A	Mus musculus	225-229
27152996-2	2016	The results show that both SnO2 and SnO2@C are capable of catalyzing oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) at the cathode of Li-air batteries, but the battery with SnO2@C displays better performance due to its unique higher conductivity, larger surface area, complex pore distribution, and huge internal space.	Oxygen	69-75	strawberry notch homolog 2	Homo sapiens	27-30
27152996-2	2016	The results show that both SnO2 and SnO2@C are capable of catalyzing oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) at the cathode of Li-air batteries, but the battery with SnO2@C displays better performance due to its unique higher conductivity, larger surface area, complex pore distribution, and huge internal space.	Oxygen	106-112	strawberry notch homolog 2	Homo sapiens	27-30
27074410-4	2016	An ortholog in the photosynthetic bacterium Rhodobacter was independently discovered as the tryptophan-rich sensory protein (TspO) and found to play a role in the response to changes in oxygen and light conditions that regulate photosynthesis and respiration.	Oxygen	186-192	translocator protein	Homo sapiens	92-123
27074410-4	2016	An ortholog in the photosynthetic bacterium Rhodobacter was independently discovered as the tryptophan-rich sensory protein (TspO) and found to play a role in the response to changes in oxygen and light conditions that regulate photosynthesis and respiration.	Oxygen	186-192	translocator protein	Homo sapiens	125-129
27242741-0	2016	In situ Dynamics of O2, pH, Light, and Photosynthesis in Ikaite Tufa Columns (Ikka Fjord, Greenland)-A Unique Microbial Habitat.	Oxygen	20-22	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	78-82
27347329-6	2016	Production of vascular endothelial growth factor (VEGF) was increased in BM-MSC monolayer sheets and it peaked at 48 h under hypoxic culture conditions (2% O2).	Oxygen	156-158	vascular endothelial growth factor A	Oryctolagus cuniculus	14-48
27347329-6	2016	Production of vascular endothelial growth factor (VEGF) was increased in BM-MSC monolayer sheets and it peaked at 48 h under hypoxic culture conditions (2% O2).	Oxygen	156-158	vascular endothelial growth factor A	Oryctolagus cuniculus	50-54
27448544-4	2016	Dopamine is readily oxidized by molecular oxygen under the catalysis of tyrosinase.	Oxygen	42-48	tyrosinase	Homo sapiens	72-82
27959931-10	2016	There were statistically significant associations between resistance to inhibition of proliferation and MATE2 expression, as well as between sensitivity to inhibition of oxygen consumption and OCT3 expression.	Oxygen	170-176	solute carrier family 22 member 3	Homo sapiens	193-197
27994436-7	2016	siRNA targeting Islet-1 was intravitreally injected into the murine model of oxygen-induced retinopathy (OIR).	Oxygen	77-83	ISL1 transcription factor, LIM/homeodomain	Mus musculus	16-23
27496192-7	2016	Furthermore, all of the indicators were detected in HeLa cells after combined treatment of DMF and N-acetyl-L-cysteine (NAC, an oxygen-free radical scavenger).	Oxygen	128-134	X-linked Kx blood group	Homo sapiens	120-123
27721085-0	2016	Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons.	Oxygen	61-67	heme oxygenase 1	Rattus norvegicus	31-36
27721085-2	2016	Our previous work found that hyperbaric oxygen (HBO) preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock protein (HSP) 32 induction.	Oxygen	40-46	heme oxygenase 1	Rattus norvegicus	288-315
27916095-0	2016	[Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure].	Oxygen	96-102	sirtuin 1	Homo sapiens	11-16
27916095-7	2016	Results Compared with the control group, SIRT1 expression in the medium-oxygen group and the high-oxygen group significantly decreased with the increase of FiO2, and the expression in the low-oxygen group and the control group was almost at a similar level.	Oxygen	72-78	sirtuin 1	Homo sapiens	41-46
27916095-7	2016	Results Compared with the control group, SIRT1 expression in the medium-oxygen group and the high-oxygen group significantly decreased with the increase of FiO2, and the expression in the low-oxygen group and the control group was almost at a similar level.	Oxygen	98-104	sirtuin 1	Homo sapiens	41-46
27916095-7	2016	Results Compared with the control group, SIRT1 expression in the medium-oxygen group and the high-oxygen group significantly decreased with the increase of FiO2, and the expression in the low-oxygen group and the control group was almost at a similar level.	Oxygen	98-104	sirtuin 1	Homo sapiens	41-46
27916095-9	2016	Conclusion There is a certain relationship between the decreased SIRT1 expression in PBMCs and the occurrence of BPD in premature infants after continuous and high-concentration oxygen exposure.	Oxygen	178-184	sirtuin 1	Homo sapiens	65-70
27828948-6	2016	SMCs lacking Fat1 (Fat1KO) grow faster, consume more oxygen for ATP production, and contain more aspartate.	Oxygen	53-59	FAT atypical cadherin 1	Mus musculus	19-25
27828948-7	2016	Notably, expression in Fat1KO cells of a modified Fat1 intracellular domain that localizes exclusively to mitochondria largely normalizes oxygen consumption, and the growth advantage of these cells can be suppressed by inhibition of mitochondrial respiration, which suggest that a Fat1-mediated growth control mechanism is intrinsic to mitochondria.	Oxygen	138-144	FAT atypical cadherin 1	Mus musculus	23-27
27828948-7	2016	Notably, expression in Fat1KO cells of a modified Fat1 intracellular domain that localizes exclusively to mitochondria largely normalizes oxygen consumption, and the growth advantage of these cells can be suppressed by inhibition of mitochondrial respiration, which suggest that a Fat1-mediated growth control mechanism is intrinsic to mitochondria.	Oxygen	138-144	FAT atypical cadherin 1	Mus musculus	50-54
27828948-7	2016	Notably, expression in Fat1KO cells of a modified Fat1 intracellular domain that localizes exclusively to mitochondria largely normalizes oxygen consumption, and the growth advantage of these cells can be suppressed by inhibition of mitochondrial respiration, which suggest that a Fat1-mediated growth control mechanism is intrinsic to mitochondria.	Oxygen	138-144	FAT atypical cadherin 1	Mus musculus	50-54
28042606-5	2016	The iodo derivative, BF2nbm(I)PLA, showed excellent F to RTP peak separation and an 0-100% oxygen sensitivity range unprecedented for metal-free RTP emitting materials.	Oxygen	91-97	forkhead box D1	Mus musculus	21-24
27831576-2	2016	Firstly we build a range of surface slab models of oxygen pre-adsorbed SnO2(110) surfaces using (1 x 1) and (2 x 1) surface unit cells and calculate their Gibbs free energies considering only oxygen chemical potential.	Oxygen	51-57	strawberry notch homolog 2	Homo sapiens	71-74
27798169-5	2016	Reversal of GC hypoxia in vivo by breathing 60% O2 during immunization resulted in reduced frequencies of GC B cells, T follicular helper cells, and plasmacytes, as well as lower expression of ICOS on T follicular helper cells.	Oxygen	48-50	inducible T cell co-stimulator	Mus musculus	193-197
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	288-292
27669376-6	2016	These results indicate that glycerin and lignosulfonate can be potentially used to stimulate RDX and HMX biodegradation by increasing oxygen consumption rates in soil.	Oxygen	134-140	radixin	Homo sapiens	93-96
26785309-5	2016	Glucose oxidase (GOx) or glucose dehydrogenase (GDH) were immobilized on bioanode and oxidize glucose while oxygen reduced in biocathode using immobilized laccase or bilirubin oxidase in order to generate sufficient power.	Oxygen	108-114	hydroxyacid oxidase 1	Homo sapiens	0-15
26785309-5	2016	Glucose oxidase (GOx) or glucose dehydrogenase (GDH) were immobilized on bioanode and oxidize glucose while oxygen reduced in biocathode using immobilized laccase or bilirubin oxidase in order to generate sufficient power.	Oxygen	108-114	hydroxyacid oxidase 1	Homo sapiens	17-20
26856676-3	2016	The Von Hippel-Lindau protein (pVHL) drives the degradation of oxygen-sensitive subunit HIF-1alpha that controls the activity of HIF-1.	Oxygen	63-69	von Hippel-Lindau tumor suppressor	Mus musculus	31-35
30044066-0	2016	[The effect of hyperbaric oxygen preconditioning on the expression of ICAM-1, VCAM-1, NF-kappaB and flap survival rate during ischemia-reperfusion injury in rat abdominal skin flap].	Oxygen	26-32	intercellular adhesion molecule 1	Rattus norvegicus	70-76
30044066-1	2016	Objective: To evaluate the effect of hyperbaric oxygen preconditioning on the expression of intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1),NF-kappaB and flap survival rate during Ischemia-Reperfusion Injury in Rat Abdominal Skin Flap.	Oxygen	48-54	intercellular adhesion molecule 1	Rattus norvegicus	92-125
30044066-10	2016	Conclusions: Hyperbaric oxygen preconditioning could decrease the expression of ICAM-1,VCAM-1,NF-kappaB and promote flap survival rate during the process of ischemia-reperfusion injury on a rat abdominal skin flap model.	Oxygen	24-30	intercellular adhesion molecule 1	Rattus norvegicus	80-86
12958309-0	2003	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	Oxygen	62-64	neutrophil cytosolic factor 1	Mus musculus	71-78
27067254-4	2016	Notably, Glut1 upregulation in response to TCR stimulation was significantly higher in T lymphocytes activated under hypoxic as compared to atmospheric oxygen conditions.	Oxygen	152-158	solute carrier family 2 member 1	Homo sapiens	9-14
27067254-6	2016	While T cells activated in hypoxia divided less than those activated in atmospheric oxygen, Glut1-Hi lymphocytes exhibited increased effector phenotype acquisition, augmented proliferation, and an inverted CD4/CD8 ratio in both oxygen conditions.	Oxygen	228-234	solute carrier family 2 member 1	Homo sapiens	92-97
27067254-8	2016	Thus, Glut1 surface levels identify human T lymphocytes with distinct effector functions in both hypoxic and atmospheric oxygen tensions.	Oxygen	121-127	solute carrier family 2 member 1	Homo sapiens	6-11
12958309-8	2003	In addition, over-expressing p47phox in MAE-p47-/- restored OS-induced O2- production and monocyte adhesion.	Oxygen	71-73	neutrophil cytosolic factor 1	Mus musculus	29-36
26872098-0	2016	Normobaric oxygen therapy inhibits HIF-1alpha and VEGF expression in perihematoma and reduces neurological function defects.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	35-45
12958309-9	2003	These results suggest that chronic exposure of endothelial cells to OS stimulates O2- and/or its derivatives produced from p47phox-dependent NAD(P)H oxidase, which, in turn, leads to monocyte adhesion, an early and critical atherogenic event.	Oxygen	82-84	neutrophil cytosolic factor 1	Mus musculus	123-130
26872098-10	2016	These results suggest that NBO therapy with oxygen delivered at 90% conferred best neuroprotection to ICH rats, potentially through amelioration of brain edema by suppressing HIF-1alpha and VEGF expression in the perihematoma.	Oxygen	44-50	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	175-185
26918461-5	2016	A mu-eta(2):eta(2)-peroxo-Cu(II)2 structure similar to those of hemocyanin and tyrosinase is reasonably obtained by using the resting state structure and dioxygen.	Oxygen	154-162	tyrosinase	Homo sapiens	79-89
26611833-3	2016	Here, we report that cultured cortical neurons isolated from fat-1 mice with high endogenous n-3 PUFAs were tolerant to oxygen-glucose deprivation/reperfusion (OGD/R) injury.	Oxygen	120-126	FAT atypical cadherin 1	Mus musculus	61-66
12881219-12	2003	The addition of 17-octadecynoic acid, a cytochrome P-450 monooxygenase inhibitor, to those inhibitors significantly attenuated the ACh-induced decreases in fluorescence intensity, whereas catalase, an enzyme that dismutates H2O2 to form water and oxygen, did not.	Oxygen	61-67	Cytochrome P450 1A1	Canis lupus familiaris	40-56
27003898-6	2016	Oxygen saturation target range during the first postnatal 72 h was 84-100% in study period 1 and 85-92% in period 2.	Oxygen	0-6	period circadian regulator 2	Homo sapiens	107-115
27003898-8	2016	The lower oxygen saturation target range increased the occurrence of hypoxemia during the first postnatal 72 h. Prevalence of DA closure failure in period 2 (21%) was significantly higher than that in period 1 (1%).	Oxygen	10-16	period circadian regulator 2	Homo sapiens	148-156
27780531-11	2016	These findings suggest that CD9 could attenuate EVT invasion under the influence of an oxygen environment and maternal endothelial cells, proposing that CD9 is a potential regulator of human placental formation.	Oxygen	87-93	CD9 molecule	Homo sapiens	28-31
26844820-1	2016	A previously unexplored palladium-catalyzed C-3 selective alkenylation of 7-azaindoles, performed in the presence of Pd(OAc)2 as the catalyst, PPh3 as the ligand, Cu(OTf)2 as an oxidative cocatalyst, and molecular oxygen (O2) as the terminal oxidant at room temperature, has been reported.	Oxygen	214-220	POU class 2 homeobox 2	Homo sapiens	163-171
26844820-1	2016	A previously unexplored palladium-catalyzed C-3 selective alkenylation of 7-azaindoles, performed in the presence of Pd(OAc)2 as the catalyst, PPh3 as the ligand, Cu(OTf)2 as an oxidative cocatalyst, and molecular oxygen (O2) as the terminal oxidant at room temperature, has been reported.	Oxygen	222-224	POU class 2 homeobox 2	Homo sapiens	163-171
27780531-11	2016	These findings suggest that CD9 could attenuate EVT invasion under the influence of an oxygen environment and maternal endothelial cells, proposing that CD9 is a potential regulator of human placental formation.	Oxygen	87-93	CD9 molecule	Homo sapiens	153-156
26815147-5	2016	For the new chemisorption-regeneration mechanism proposed in this study, the adsorbed Hg(0) was first oxidized with surface chemisorbed oxygen species to form HgO; the HgO could desorb from the surface of catalysts by itself or react with adsorbed HCl to be release in the form of gaseous HgCl2.	Oxygen	136-142	homogentisate 1,2-dioxygenase	Homo sapiens	159-162
14572612-5	2003	When cultured at low cell density, MEFs from Gpx4(+/-) mice also showed retarded growth under normal culture conditions (20% oxygen) that was reversed by culturing under low oxygen (2% oxygen).	Oxygen	174-180	glutathione peroxidase 4	Mus musculus	45-49
26815147-5	2016	For the new chemisorption-regeneration mechanism proposed in this study, the adsorbed Hg(0) was first oxidized with surface chemisorbed oxygen species to form HgO; the HgO could desorb from the surface of catalysts by itself or react with adsorbed HCl to be release in the form of gaseous HgCl2.	Oxygen	136-142	homogentisate 1,2-dioxygenase	Homo sapiens	168-171
14572612-5	2003	When cultured at low cell density, MEFs from Gpx4(+/-) mice also showed retarded growth under normal culture conditions (20% oxygen) that was reversed by culturing under low oxygen (2% oxygen).	Oxygen	174-180	glutathione peroxidase 4	Mus musculus	45-49
14555671-8	2003	A single HBO treatment (100% oxygen, 3 ATA for 1 h) 1 h after hypoxia reduced the enhanced caspase-3 expression and activity, attenuated the PARP cleavage, and decreased the number of TUNEL-positive cells observed in the cortex and hippocampus.	Oxygen	29-35	poly (ADP-ribose) polymerase 1	Rattus norvegicus	141-145
26721561-6	2016	We observe that zebrafish Ngb and Cygb2 have comparable spectral features to those of human Ngb and Cygb, consistent with a six-coordinate heme, whereas unexpectedly Cygb1 has a five-coordinate heme, a slower autoxidation and in general has properties more akin to oxygen transport proteins.	Oxygen	265-271	cytoglobin 2	Danio rerio	34-39
30193449-3	2016	It is assumed that the basis of the resistance mechanisms of the body to reduce the hypoxic exposure is multifactorial effects of increased levels of IL-1 R, activation of HIF-1 a and NO production in the operation of the systems responsible for maintaining oxygen homeostasis.	Oxygen	258-264	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	172-179
27798188-10	2016	Specifically, the interaction of KCNB1 channels with reactive oxygen species plays a major role in the etiology of mouse model of traumatic brain injury (TBI), a condition associated with extensive oxidative stress.	Oxygen	62-68	potassium voltage gated channel, Shab-related subfamily, member 1	Mus musculus	33-38
26853854-2	2016	ClO radicals were generated following the photolysis of Cl2 and Cl2O gas mixtures diluted in nitrogen and oxygen.	Oxygen	106-112	endogenous retrovirus group W member 5	Homo sapiens	56-59
14580376-1	2003	The transforming growth factor-beta 3 (TGF-beta 3) is involved in oxygen-dependent differentiation processes during placental development and pregnancy disorders.	Oxygen	66-72	transforming growth factor, beta 3	Mus musculus	4-37
26852918-2	2016	Previously, we reported that N-myc downstream-regulated gene 1 (NDRG1) is strongly up-regulated under hypoxia and may play an important role in tumor adaptation to fluctuating oxygen concentrations.	Oxygen	176-182	N-myc downstream regulated 1	Homo sapiens	29-62
27790986-2	2016	These enzymes feature a unique active site consisting of two spatially separated (by 11 A in PHM) and magnetically noncoupled copper centers that enables 1e- activation of O2 for hydrogen atom abstraction (HAA) of substrate C-H bonds and subsequent hydroxylation.	Oxygen	172-174	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	93-96
26852918-2	2016	Previously, we reported that N-myc downstream-regulated gene 1 (NDRG1) is strongly up-regulated under hypoxia and may play an important role in tumor adaptation to fluctuating oxygen concentrations.	Oxygen	176-182	N-myc downstream regulated 1	Homo sapiens	64-69
14580376-1	2003	The transforming growth factor-beta 3 (TGF-beta 3) is involved in oxygen-dependent differentiation processes during placental development and pregnancy disorders.	Oxygen	66-72	transforming growth factor, beta 3	Mus musculus	39-49
12902034-0	2003	Acetylcholinesterase activation in organotypic rat hippocampal slice cultures deprived of oxygen and glucose.	Oxygen	90-96	acetylcholinesterase	Rattus norvegicus	0-20
26718737-7	2016	The results of the present study demonstrated that TRPC6 was increased in the distal PVs of CHPH rats, and in PVSMCs exposed to hypoxic conditions (4% O2, 72 h); however, TRPC1 was not.	Oxygen	151-153	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	51-56
26671307-9	2016	CPAP withdrawal led to a recurrence of OSA (mean difference in change of oxygen desaturation index between groups +30.3/h; 95% CI 19.8/h,40.7/h, p&lt;0.001) which was accompanied by a significant change in 62 exhaled features (16 metabolites identified).	Oxygen	73-79	centromere protein J	Homo sapiens	0-4
27552707-1	2016	Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1-selective small-molecule inhibitor.	Oxygen	206-212	solute carrier family 2 member 1	Homo sapiens	70-75
27739509-9	2016	5% O2 significantly increased the proliferation rate, migration ability, expression of stem cell markers (CXCR4 and G-CSFR), and expression of SOX2, VEGF, NGF, and BDNF genes of DPSCs.	Oxygen	3-5	C-X-C motif chemokine receptor 4	Homo sapiens	106-111
27739509-9	2016	5% O2 significantly increased the proliferation rate, migration ability, expression of stem cell markers (CXCR4 and G-CSFR), and expression of SOX2, VEGF, NGF, and BDNF genes of DPSCs.	Oxygen	3-5	SRY-box transcription factor 2	Homo sapiens	143-147
27739509-9	2016	5% O2 significantly increased the proliferation rate, migration ability, expression of stem cell markers (CXCR4 and G-CSFR), and expression of SOX2, VEGF, NGF, and BDNF genes of DPSCs.	Oxygen	3-5	brain derived neurotrophic factor	Homo sapiens	164-168
12927819-10	2003	Inducibility of HO-1 in G(0)/G(1) phase is essential and probably regulated by a complex system involving oxygen species to assure controlled cell growth.	Oxygen	106-112	heme oxygenase 1	Homo sapiens	16-20
27731369-6	2016	Thus, PGP is essential to sustain cell proliferation in the presence of oxygen.	Oxygen	72-78	phosphoglycolate phosphatase	Mus musculus	6-9
26647118-5	2016	Furthermore, Boc protected bromo homo propargyl amines undergo 6-endo-dig cyclization through Boc oxygen to give bromomethylene substituted oxazinones.	Oxygen	98-104	BOC cell adhesion associated, oncogene regulated	Homo sapiens	13-16
26647118-5	2016	Furthermore, Boc protected bromo homo propargyl amines undergo 6-endo-dig cyclization through Boc oxygen to give bromomethylene substituted oxazinones.	Oxygen	98-104	BOC cell adhesion associated, oncogene regulated	Homo sapiens	94-97
26631962-10	2016	The results indicate that myoglobin enhances O2 supply while GbX protects the cell membrane from ROS-stress.	Oxygen	45-47	myoglobin	Mus musculus	26-35
12851422-3	2003	AVP also decreased splanchnic oxygen delivery (Do2) and increased splanchnic and renal oxygen extraction significantly during basal conditions.	Oxygen	30-36	arginine vasopressin	Canis lupus familiaris	0-3
27291495-4	2016	The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement.	Oxygen	43-49	solute carrier family 25 member 5	Homo sapiens	63-70
27245882-0	2016	Effects of PTEN inhibition on the regulation of Tau phosphorylation in rat cortical neuronal injury after oxygen and glucose deprivation.	Oxygen	106-112	phosphatase and tensin homolog	Rattus norvegicus	11-15
12851422-3	2003	AVP also decreased splanchnic oxygen delivery (Do2) and increased splanchnic and renal oxygen extraction significantly during basal conditions.	Oxygen	87-93	arginine vasopressin	Canis lupus familiaris	0-3
27245882-1	2016	OBJECTIVE: This report investigated the involvement of the PTEN pathway in the regulation of Tau phosphorylation using an oxygen and glucose deprivation (OGD) model with rat cortical neurons.	Oxygen	122-128	phosphatase and tensin homolog	Rattus norvegicus	59-63
27539189-6	2016	Cells cultured dynamically at 5% oxygen exhibited the best expansion: 30-fold increase by flow cytometry, 120-fold increase by colony assay, and 11% of human CD45 engraftment in the bone marrow of NOD/SCID mice.	Oxygen	33-39	protein tyrosine phosphatase receptor type C	Homo sapiens	158-162
12716879-8	2003	Analysis of the distance from the closest carboxylate oxygen of the glutamate base catalyst to C-4 of a bound acyl-CoA ligand for medium chain, short chain, and isovaleryl-CoA dehydrogenases suggests that the increased rate of inactivation reflects the carboxylate oxygen to ligand C-4 distance in the binary complexes.	Oxygen	54-60	complement C4A (Rodgers blood group)	Homo sapiens	95-98
27650532-4	2016	Bis (trifluoromethylsulfonyl)imide (NTf2) anion of ionic liquid electrolyte was selected to enhance the CO/O2 adsorption and to facilitate electro-catalyzed oxidation of Ni (OH)2 to NiOOH by increasing the electrophilicity of catalytic interface.	Oxygen	107-109	nuclear transport factor 2	Homo sapiens	36-40
26488220-1	2016	OBJECTIVE: To test the hypothesis that hyperbaric oxygen therapy ameliorates delayed cognitive impairment after acute carbon monoxide poisoning by promoting neurogenesis through upregulating the brain-derived neurotrophic factor in the hippocampus.	Oxygen	50-56	brain-derived neurotrophic factor	Rattus norvegicus	195-228
12716879-8	2003	Analysis of the distance from the closest carboxylate oxygen of the glutamate base catalyst to C-4 of a bound acyl-CoA ligand for medium chain, short chain, and isovaleryl-CoA dehydrogenases suggests that the increased rate of inactivation reflects the carboxylate oxygen to ligand C-4 distance in the binary complexes.	Oxygen	265-271	complement C4A (Rodgers blood group)	Homo sapiens	95-98
26488220-15	2016	The hyperbaric oxygen treatment also promoted a sustained increase in hippocampal brain-derived neurotrophic factor level.	Oxygen	15-21	brain-derived neurotrophic factor	Rattus norvegicus	82-115
27683542-8	2016	Results showed that DMT robustly increases the survival of these cell types in severe hypoxia (0.5% O2) through the Sig-1R.	Oxygen	100-102	sigma non-opioid intracellular receptor 1	Homo sapiens	116-122
26488220-16	2016	Blockade of hippocampal brain-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human TrkB-Fc chimera significantly blunted the protection by the hyperbaric oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurotrophic factor mimicked the action of hyperbaric oxygen and preserved hippocampal neurogenesis after acute carbon monoxide poisoning.	Oxygen	198-204	brain derived neurotrophic factor	Homo sapiens	24-57
12716879-8	2003	Analysis of the distance from the closest carboxylate oxygen of the glutamate base catalyst to C-4 of a bound acyl-CoA ligand for medium chain, short chain, and isovaleryl-CoA dehydrogenases suggests that the increased rate of inactivation reflects the carboxylate oxygen to ligand C-4 distance in the binary complexes.	Oxygen	265-271	complement C4A (Rodgers blood group)	Homo sapiens	282-285
26488220-16	2016	Blockade of hippocampal brain-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human TrkB-Fc chimera significantly blunted the protection by the hyperbaric oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurotrophic factor mimicked the action of hyperbaric oxygen and preserved hippocampal neurogenesis after acute carbon monoxide poisoning.	Oxygen	198-204	brain derived neurotrophic factor	Homo sapiens	278-311
26488220-16	2016	Blockade of hippocampal brain-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human TrkB-Fc chimera significantly blunted the protection by the hyperbaric oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurotrophic factor mimicked the action of hyperbaric oxygen and preserved hippocampal neurogenesis after acute carbon monoxide poisoning.	Oxygen	346-352	brain derived neurotrophic factor	Homo sapiens	24-57
26488220-18	2016	The hyperbaric oxygen treatment notably restored the cognitive impairment in a brain-derived neurotrophic factor-dependent manner.	Oxygen	15-21	brain-derived neurotrophic factor	Rattus norvegicus	79-112
26488220-19	2016	CONCLUSIONS: The early hyperbaric oxygen treatment may alleviate delayed memory impairment after acute carbon monoxide poisoning by preserving adult neurogenesis via an increase in hippocampal brain-derived neurotrophic factor content.	Oxygen	34-40	brain-derived neurotrophic factor	Rattus norvegicus	193-226
25964066-5	2016	Activation in the A1/C1 region was examined in more detail to ascertain whether an O2-sensitive subpopulation of these cells containing heme oxygenase 2 (HMOX2) may drive hypoxic brain responses before the maturation of peripheral O2-sensing.	Oxygen	83-85	heme oxygenase 2	Gallus gallus	136-152
27515002-6	2016	Using extracellular flux assays we observed that LCC1, LCC2, and LCC9 cells showed similar oxygen consumption rate (OCR), but lower mitochondrial reserve capacity which was correlated with lower Succinate Dehydrogenase Complex, Subunit B in LCC1 and LCC2 cells.	Oxygen	91-97	C-C motif chemokine ligand 16	Homo sapiens	49-53
27494416-10	2016	Oxygen orbitals, namely, O-2p states in the valence band maximum and the sp-hybridized states in the conduction band minimum, are mainly involved in the electronic transitions.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	25-29
25964066-5	2016	Activation in the A1/C1 region was examined in more detail to ascertain whether an O2-sensitive subpopulation of these cells containing heme oxygenase 2 (HMOX2) may drive hypoxic brain responses before the maturation of peripheral O2-sensing.	Oxygen	83-85	heme oxygenase 2	Gallus gallus	154-159
12626331-2	2003	Hyperoxia exposure (&gt;95% O2 days 4-14) arrests lung alveolarization and may do so through suppression of the VEGF signaling system.	Oxygen	28-30	vascular endothelial growth factor A	Rattus norvegicus	112-116
27089175-10	2016	We conclude that TrxR1 represents a novel therapeutic target to prevent oxygen-mediated neonatal lung injury.	Oxygen	72-78	thioredoxin reductase 1	Mus musculus	17-22
12820886-12	2003	The best correlation of the distances between the uncoordinated Gla oxygen atoms is with the intercalcium distance of 9.43 A in hydroxyapatite.	Oxygen	68-74	GLA	Bos taurus	64-67
27385725-10	2016	Blastocysts cultured under atmospheric oxygen levels have significantly increased p66Shc mRNA transcript and protein abundances compared to in vivo controls (P &lt; 0.05).	Oxygen	39-45	src homology 2 domain-containing transforming protein C1	Mus musculus	82-88
26231684-10	2016	WHAT IS KNOWN: Our previous studies showed that CeasIng Cpap At standarD criteriA (CICADA) significantly reduces CPAP time, oxygen requirements and caffeine use.	Oxygen	124-130	centromere protein J	Homo sapiens	56-60
12939533-8	2003	Mean skin temperature (Tsk) of the control increased gradually after the onset of sweating, while the Tsks at 25%O(2) and 30%O(2) maintained a constant level during sweating.	Oxygen	113-117	testis specific serine kinase substrate	Homo sapiens	102-106
26608911-1	2016	We have previously shown that CD4(+) T cells from B6.Sle1Sle2.Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-D-glucose, which inhibits glucose metabolism, and metformin, which inhibits oxygen consumption, normalized lupus T cell functions in vitro and reverted disease in mice.	Oxygen	237-243	CD4 antigen	Mus musculus	30-33
27178903-4	2016	However, they presented a low permeability to O2 and CO2 (0.47x10(-16)molm/m(2)sPa and 5.8x10(-16)molm/m(2)sPa, respectively).	Oxygen	46-48	surfactant protein A2	Homo sapiens	79-82
26666247-8	2016	RESULTS: Per UGT1A1*28 allele, odds were increased for any need of supplementary oxygen (odds ratio 1.26; 1.05-1.50) and for BPD (odds ratio 1.71; 1.23-2.39), the need of supplementary oxygen increased by 6.38 days (1.87-10.89), and chance per day of no longer needing supplementary oxygen was reduced (hazard rate 0.84; 0.76-0.93).	Oxygen	81-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
12939533-8	2003	Mean skin temperature (Tsk) of the control increased gradually after the onset of sweating, while the Tsks at 25%O(2) and 30%O(2) maintained a constant level during sweating.	Oxygen	125-129	testis specific serine kinase substrate	Homo sapiens	102-106
26666247-8	2016	RESULTS: Per UGT1A1*28 allele, odds were increased for any need of supplementary oxygen (odds ratio 1.26; 1.05-1.50) and for BPD (odds ratio 1.71; 1.23-2.39), the need of supplementary oxygen increased by 6.38 days (1.87-10.89), and chance per day of no longer needing supplementary oxygen was reduced (hazard rate 0.84; 0.76-0.93).	Oxygen	185-191	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
26666247-8	2016	RESULTS: Per UGT1A1*28 allele, odds were increased for any need of supplementary oxygen (odds ratio 1.26; 1.05-1.50) and for BPD (odds ratio 1.71; 1.23-2.39), the need of supplementary oxygen increased by 6.38 days (1.87-10.89), and chance per day of no longer needing supplementary oxygen was reduced (hazard rate 0.84; 0.76-0.93).	Oxygen	185-191	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
26666247-13	2016	CONCLUSIONS: Compared to the common genotype, UGT1A1*28 genotypes were associated with an increased need of oxygen supplementation and risk of BPD in very preterm newborns.	Oxygen	108-114	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-52
27342561-8	2016	RpoE might function by signaling the initial response to oxygen limitation.	Oxygen	57-63	RNA polymerase sigma factor RpoE	Shewanella oneidensis MR-1	0-4
12832481-4	2003	We show that oxygen-dependent protein degradation is restricted to HIF-1alpha, as HIF-2alpha protein is detected in MEFs regardless of oxygenation and is localized primarily to the cytoplasm.	Oxygen	13-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	67-77
26681189-0	2016	Adenoviral Vector-Mediated Delivery of p21WAF1/CIP1 Prevents Retinal Neovascularization in an Oxygen-Induced Retinopathy Model.	Oxygen	94-100	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	47-51
26859849-13	2016	In the presence of ADH, Ang II increased O2(-) production in TALs from SHR by 309% (p = 0.015 vs. basal).	Oxygen	41-43	angiogenin	Rattus norvegicus	24-27
12832481-4	2003	We show that oxygen-dependent protein degradation is restricted to HIF-1alpha, as HIF-2alpha protein is detected in MEFs regardless of oxygenation and is localized primarily to the cytoplasm.	Oxygen	13-19	endothelial PAS domain protein 1	Mus musculus	82-92
12832481-7	2003	We propose that HIF-2alpha is not a redundant transcription factor of HIF-1alpha for hypoxia-induced gene expression and show evidence that there is a cell type-specific modulator(s) that enables selective activation of HIF-1alpha but not HIF-2alpha in response to low-oxygen stress.	Oxygen	269-275	hypoxia inducible factor 1, alpha subunit	Mus musculus	220-230
12828921-8	2003	At lower oxygen tensions, MAPK phosphorylation was maximal at 1 ng/ml EGF compared with 10 ng/ml for the PI-3-kinase path.	Oxygen	9-15	epidermal growth factor	Homo sapiens	70-73
27228610-7	2016	Among the active oxygen scavenging enzymes, CAT was most sensitive to drought stress.	Oxygen	17-23	catalase	Beta vulgaris subsp. vulgaris	44-47
26646423-4	2015	The ones found most influential on chemical changes were the O2 consumed in the first saturation without equivalent SO2 consumption (O2preSO2) and the O2 consumed when levels of free SO2 were below 5 mg/L (radical forming O2).	Oxygen	61-63	immunoglobulin kappa variable 1D-39	Homo sapiens	133-141
28357578-0	2016	Effect of fatty acid interaction on myoglobin oxygen affinity and triglyceride metabolism.	Oxygen	46-52	myoglobin	Mus musculus	36-45
28357578-1	2016	Recent studies have suggested myoglobin (Mb) may have other cellular functions in addition to storing and transporting O2.	Oxygen	119-121	myoglobin	Mus musculus	30-39
28357578-1	2016	Recent studies have suggested myoglobin (Mb) may have other cellular functions in addition to storing and transporting O2.	Oxygen	119-121	myoglobin	Mus musculus	41-43
26928132-8	2016	Similarly pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2( -)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2.	Oxygen	148-150	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	134-138
27172123-6	2016	Based on parallels with the effect of Ni on the hypoxic response in animals, we propose that a possible link between Cu, oxygen and Ni sensing is an as yet uncharacterized prolyl hydroxylase that regulates a co-activator of CRR1.	Oxygen	121-127	uncharacterized protein	Chlamydomonas reinhardtii	224-228
27000416-8	2016	At 30 min of reperfusion, state 3 mitochondrial O2 consumption was impaired by 13% in Wt and by 33% in DN-Trx1.	Oxygen	48-50	thioredoxin 1	Mus musculus	106-110
26341689-6	2015	Upon co-expression of splice variant Rac1b, but not of Rac1, the B-Raf-induced senescence phenotype was reverted and expression of the cell-cycle inhibitors downregulated in a reactive oxygen-species dependent manner.	Oxygen	185-191	Rac family small GTPase 1	Homo sapiens	37-41
26511316-3	2015	This is an O2-dependent process and catalyzed by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.	Oxygen	11-13	tryptophan 2,3-dioxygenase	Homo sapiens	81-107
26577067-0	2015	Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.	Oxygen	0-8	lysine demethylase 4A	Homo sapiens	59-65
12828921-9	2003	The EGF receptor was spontaneously phosphorylated with increasing culture times at lower oxygen levels, an effect reflected down-stream by PI-3-kinase and Akt phosphorylation.	Oxygen	89-95	epidermal growth factor	Homo sapiens	4-7
12704646-6	2003	Although the mechanisms responsible for the growth promoting properties of HO-1 are not well established, HO-1 can indirectly influence growth by regulating the synthesis of growth factors and by modulating the delivery of oxygen or nutrients to specific target tissues.	Oxygen	223-229	heme oxygenase 1	Homo sapiens	75-79
26568372-2	2015	The synergistic interaction existing between Fe-Fe2O3 and NGr helped the system to narrow down the overpotential for the oxygen reduction reaction (ORR) by bringing a significant positive shift to the reduction onset potential, which is just 15 mV higher than its Pt-counterpart.	Oxygen	121-127	reticulon 4 receptor	Homo sapiens	58-61
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Oxygen	117-123	reticulon 4 receptor	Homo sapiens	173-176
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Oxygen	117-123	reticulon 4 receptor	Homo sapiens	469-472
27458452-2	2016	A characterization of Candida albicans pho4 mutants revealed that these cells are more susceptible to both osmotic and oxidative stress and that this effect is diminished in the presence of 5% CO2 or anaerobiosis, reflecting the relevance of oxygen metabolism in the Pho4-mediated response.	Oxygen	242-248	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	39-43
12704646-6	2003	Although the mechanisms responsible for the growth promoting properties of HO-1 are not well established, HO-1 can indirectly influence growth by regulating the synthesis of growth factors and by modulating the delivery of oxygen or nutrients to specific target tissues.	Oxygen	223-229	heme oxygenase 1	Homo sapiens	106-110
27170658-10	2016	In isolated primary fetal sheep hepatocytes, incubation in low oxygen (3%) increased PCK1 mRNA threefold compared with incubation in normal oxygen (21%).	Oxygen	63-69	phosphoenolpyruvate carboxykinase, cytosolic [GTP]	Ovis aries	85-89
26151122-8	2015	Taken together, these data introduce PTH as a regulator of oxygen-independent HIF-1alpha levels through a mechanism involving cyclic AMP, Hsp90, and the cytoskeleton.	Oxygen	59-65	heat shock protein, 2	Mus musculus	138-143
12756283-3	2003	Within the sarcoplasm, myoglobin, a mobile carrier of oxygen, is developed in response to mitochondrial demand and augments the flow of oxygen to the mitochondria.	Oxygen	54-60	myoglobin	Homo sapiens	23-32
12756283-3	2003	Within the sarcoplasm, myoglobin, a mobile carrier of oxygen, is developed in response to mitochondrial demand and augments the flow of oxygen to the mitochondria.	Oxygen	136-142	myoglobin	Homo sapiens	23-32
27022655-4	2015	Therefore, lipid alterations induced by oxygen and glucose deprivation enhance beta-secretase 1 activity, favor its proximity to amyloid precursor protein and may concur to increased amyloidogenic cleavage.	Oxygen	40-46	beta-secretase 1	Rattus norvegicus	79-95
27022655-4	2015	Therefore, lipid alterations induced by oxygen and glucose deprivation enhance beta-secretase 1 activity, favor its proximity to amyloid precursor protein and may concur to increased amyloidogenic cleavage.	Oxygen	40-46	amyloid beta precursor protein	Rattus norvegicus	129-154
27190130-6	2016	First, we showed, by computational analysis and measurements of oxygen consumption and promoter activities, that Swi3, not Swi2, regulates genes encoding functions involved in respiration and oxygen consumption.	Oxygen	64-70	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	113-117
27190130-6	2016	First, we showed, by computational analysis and measurements of oxygen consumption and promoter activities, that Swi3, not Swi2, regulates genes encoding functions involved in respiration and oxygen consumption.	Oxygen	192-198	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	113-117
27190130-8	2016	Additionally, our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters.	Oxygen	62-68	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	35-39
12756283-4	2003	Myoglobin-facilitated oxygen diffusion, perhaps by virtue of reduction of dimensionality of diffusion from three dimensions towards two dimensions in the narrow spaces available between mitochondria, is rapid relative to other parameters of cell respiration.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
12756283-6	2003	Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 micro mol l(-1) oxygen) by equilibrium with myoglobin, falls close to the operational K(m) of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization.	Oxygen	13-19	myoglobin	Homo sapiens	138-147
12756283-6	2003	Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 micro mol l(-1) oxygen) by equilibrium with myoglobin, falls close to the operational K(m) of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization.	Oxygen	110-116	myoglobin	Homo sapiens	138-147
27445795-6	2016	These effects were accompanied by a positive regulation of neuroglobin, an oxygen-binding and sensor protein, which may serve as a regulator of ROS and nitrogen reactive species (NOS), and these protective effects of testosterone may be at least in part mediated by estradiol and DHT.	Oxygen	75-81	neuroglobin	Homo sapiens	59-70
27366678-1	2016	AIM: To investigate the signal transduction mechanism of matrix metalloproteinase-9 (MMP-9) mediated- vascular endothelial growth factor (VEGF) expression and retinal neovascularization (RNV) in oxygen-induced retinopathy (OIR) model.	Oxygen	195-201	vascular endothelial growth factor A	Mus musculus	102-136
27366678-1	2016	AIM: To investigate the signal transduction mechanism of matrix metalloproteinase-9 (MMP-9) mediated- vascular endothelial growth factor (VEGF) expression and retinal neovascularization (RNV) in oxygen-induced retinopathy (OIR) model.	Oxygen	195-201	vascular endothelial growth factor A	Mus musculus	138-142
26094846-4	2015	Transgenic OC precursors expressing constitutively active NIK showed normal RANKL-induced mitochondrial biogenesis (OxPhos expression and mitochondria copy number) compared to controls, but larger mitochondrial dimensions and increased oxygen consumption rates, suggesting increased mitochondrial function.	Oxygen	236-242	mitogen-activated protein kinase kinase kinase 14	Mus musculus	58-61
25303169-4	2015	RESULTS: Maximal oxygen consumption and 1-RM strength of lower body increased (P&lt;0.05) in the AD and SAR groups.	Oxygen	17-23	sarcosine dehydrogenase	Homo sapiens	104-107
26624889-9	2015	Furthermore, to demonstrate the utility of the developed sensing system, we demonstrated the mapping of the oxygen consumption rate of rat brain slices and succeeded in visualizing a clear difference among the layer structures of the hippocampus, i.e., the cornu ammonis (CA1 and CA3) and dentate gyrus (DG).	Oxygen	108-114	carbonic anhydrase 3	Rattus norvegicus	280-283
12756283-6	2003	Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 micro mol l(-1) oxygen) by equilibrium with myoglobin, falls close to the operational K(m) of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization.	Oxygen	110-116	myoglobin	Homo sapiens	138-147
12756283-6	2003	Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 micro mol l(-1) oxygen) by equilibrium with myoglobin, falls close to the operational K(m) of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization.	Oxygen	110-116	myoglobin	Homo sapiens	138-147
27247382-4	2016	Here, we use live-cell imaging to demonstrate that OPTN, NDP52, and TAX1BP1 are recruited to mitochondria with similar kinetics following either mitochondrial depolarization or localized generation of reactive oxygen species, leading to sequestration by the autophagosome within ~45 min after insult.	Oxygen	210-216	Tax1 binding protein 1	Homo sapiens	68-75
12756283-6	2003	Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 micro mol l(-1) oxygen) by equilibrium with myoglobin, falls close to the operational K(m) of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization.	Oxygen	110-116	myoglobin	Homo sapiens	138-147
12729929-6	2003	Power saturation EPR experiments indicate that for the sample compositions described here, the spin-lattice relaxation rate of the CLS spin label was increased by varying amounts in the presence of different lanthanide (Gd(3+), Dy(3+), Er(3+), Yb(3+), and Tm(3+)) ions, and in the presence of molecular oxygen.	Oxygen	303-309	cardiolipin synthase 1	Homo sapiens	131-134
27159412-5	2016	2014, 136, 10846) that bubbling of O2 into a solution of Fe(II)(BDPP) (H2BDPP = 2,6-bis[[(S)-2-(diphenylhydroxymethyl)-1-pyrrolidinyl]methyl]pyridine) in tetrahydrofuran at -80  C generates a high-spin (SFe = (5)/2) iron(III) superoxo adduct, 1.	Oxygen	35-37	spindlin 1	Homo sapiens	197-201
27159412-9	2016	A theoretical model that considers spin-dependent electron transfer for the cases where the doubly occupied pi* orbital of the superoxo ligand is either "in" or "out" of the plane defined by the bent Fe-OO moiety correctly predicts that 1 has an S = 3 ground state, in contrast to the density functional theory calculations for 1, which give a ground state with both the wrong spin and orbital configuration.	Oxygen	203-205	spindlin 1	Homo sapiens	35-39
27159412-9	2016	A theoretical model that considers spin-dependent electron transfer for the cases where the doubly occupied pi* orbital of the superoxo ligand is either "in" or "out" of the plane defined by the bent Fe-OO moiety correctly predicts that 1 has an S = 3 ground state, in contrast to the density functional theory calculations for 1, which give a ground state with both the wrong spin and orbital configuration.	Oxygen	203-205	spindlin 1	Homo sapiens	377-381
26420898-3	2015	Unlike hospital CPAP devices, which require electricity, CPAP devices for ambulance use need only an oxygen source to function.	Oxygen	101-107	centromere protein J	Homo sapiens	57-61
26423768-0	2015	A ventilation technique for oxygenation and carbon dioxide elimination in CPR: Continuous insufflation of oxygen at three levels of pressure in a pig model.	Oxygen	28-34	cytochrome p450 oxidoreductase	Sus scrofa	74-77
12752442-6	2003	The expression of the two ERO1-L isoforms therefore appears to be differently regulated, in the way that ERO1-Lalpha expression is mainly controlled by the cellular oxygen tension, whilst ERO1-Lbeta is triggered mainly by UPR.	Oxygen	165-171	endoplasmic reticulum oxidoreductase 1 alpha	Rattus norvegicus	26-32
26648302-1	2015	OBJECTIVE: To explore the relationship between deacetylase sirtuin 1 (SIRT1) and reactive oxygen species (ROS) after oxygen therapy in the peripheral blood mononuclear cells (PBMCs) of the premature infants.	Oxygen	90-96	sirtuin 1	Homo sapiens	59-68
26865248-4	2016	We further demonstrated that HDAC9 contributed to oxygen-glucose deprivation-induced brain microvessel endothelial cell dysfunction as demonstrated by the increased inflammatory responses, cellular apoptosis and endothelial cell permeability dysfunction accompanied by reduced expression of tight-junction proteins.	Oxygen	50-56	histone deacetylase 9	Rattus norvegicus	29-34
26648302-1	2015	OBJECTIVE: To explore the relationship between deacetylase sirtuin 1 (SIRT1) and reactive oxygen species (ROS) after oxygen therapy in the peripheral blood mononuclear cells (PBMCs) of the premature infants.	Oxygen	90-96	sirtuin 1	Homo sapiens	70-75
12662351-8	2003	Reactive oxygen metabolite-induced inflammatory changes in kidney and liver tissues were evaluated by measuring myeloperoxidase (MPO) activity, an index of neutrophil infiltration.	Oxygen	9-15	myeloperoxidase	Rattus norvegicus	112-127
26427541-4	2015	Dioxygen is activated when a micro-environment suitable for a square-planar Cu(2+) coordination is present and a negatively charged group like Asp 1 carboxylate takes part in the Cu coordination anti to O2.	Oxygen	0-8	beta-secretase 2	Homo sapiens	143-148
27508152-8	2016	Additionally, beta-alanine-treated cells exhibited significantly increased oxygen consumption compared to control in a PPARbeta/delta-dependent manner.	Oxygen	75-81	peroxisome proliferator activated receptor delta	Homo sapiens	119-127
26427541-4	2015	Dioxygen is activated when a micro-environment suitable for a square-planar Cu(2+) coordination is present and a negatively charged group like Asp 1 carboxylate takes part in the Cu coordination anti to O2.	Oxygen	203-205	beta-secretase 2	Homo sapiens	143-148
26296657-10	2015	Additionally, our work showed that the oxygen sensors PHD1 and PHD3 are involved in CERKL degradation.	Oxygen	39-45	egl-9 family hypoxia inducible factor 3	Homo sapiens	63-67
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	Oxygen	159-165	acyl-CoA oxidase 1	Homo sapiens	0-19
26950727-4	2016	RESULTS: We observed that chemical and genetic inhibition of Nox2 in rats and mice resulted in the prevention of CsA-induced hypoxia independent of regional perfusion (blood oxygen level-dependent magnetic resonance imaging and dynamic contrast-enhanced magnetic resonance imaging, pimonidazole, HIF-1alpha).	Oxygen	174-180	cytochrome b-245 beta chain	Rattus norvegicus	61-65
27228352-5	2016	Or does the progressive lack of iron-sulphur clusters (ISCs), induced by reduced frataxin, cause an inhibition of the electron transport chain complexes (CI, II and III) leading to reactive oxygen species escaping from oxidative phosphorylation reactions?	Oxygen	190-196	frataxin	Mus musculus	81-89
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	Oxygen	159-165	acyl-CoA oxidase 1	Homo sapiens	21-24
27152023-5	2016	The ITC data also showed that although the copper ion alone hardly contributes to affinity, substrate binding is enhanced for metal-loaded enzymes that are supplied with cyanide, a mimic of O2 (-) Studies with CDH and its isolated heme b cytochrome domain unambiguously showed that the cytochrome domain of CDH interacts with the copper site of the LPMO and that substrate binding precludes interaction with CDH.	Oxygen	190-192	choline dehydrogenase	Homo sapiens	210-213
12662351-8	2003	Reactive oxygen metabolite-induced inflammatory changes in kidney and liver tissues were evaluated by measuring myeloperoxidase (MPO) activity, an index of neutrophil infiltration.	Oxygen	9-15	myeloperoxidase	Rattus norvegicus	129-132
12710916-3	2003	In this paper, I highlight the mathematical link between cerebral oxygen exchange at sea level - this is reflected in the magnitude of the oxygen extraction coefficient - and a change in brain blood flow at altitude; this link has been overlooked.	Oxygen	66-72	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
27323011-0	2016	A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells.	Oxygen	78-84	microRNA 152	Homo sapiens	2-14
26216936-6	2015	Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to beta2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses.	Oxygen	79-85	phospholipid scramblase 1	Homo sapiens	0-25
12710916-3	2003	In this paper, I highlight the mathematical link between cerebral oxygen exchange at sea level - this is reflected in the magnitude of the oxygen extraction coefficient - and a change in brain blood flow at altitude; this link has been overlooked.	Oxygen	139-145	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
12710916-4	2003	A lower oxygen extraction coefficient at sea level can act - at altitude - to reduce the capacity of the intracranial compartment to accommodate brain swelling, exacerbate increases in cell volume, promote the stimulation of angiogenesis, and further cerebral edema, each of which may contribute to acute mountain sickness.	Oxygen	8-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
26203919-5	2015	The short-term exposure of SCAP to glucose/oxygen deprivation (GOD) in the presence, but mainly in deprivation, of serum (SGOD) elicited a proangiogenesis effect indicated by expression of angiogenesis-related genes involved in vascular endothelial growth factor (VEGF)/VEGFR and angiopoietins/Tie pathways.	Oxygen	43-49	kinase insert domain receptor	Homo sapiens	270-275
26041127-2	2016	In this work, we present a 3D microreactor capable of maintaining metabolically active HepG2/C3A spheroids for over 28 days in vitro under stable oxygen gradients mimicking the in vivo microenvironment.	Oxygen	146-152	complement C3	Homo sapiens	93-96
12588875-2	2003	The transactivation activity of HIF complexes requires the recruitment of p300/CREB-binding protein (CBP) by HIF-1 alpha and HIF-2 alpha that undergo oxygen-dependent degradation.	Oxygen	150-156	endothelial PAS domain protein 1	Homo sapiens	125-136
26937714-0	2016	Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction.	Oxygen	26-32	LOC105613195	Ovis aries	91-98
26649273-5	2015	This in vitro study extends earlier investigations of the oxidation of Arabidopsis cryptochrome1 by molecular oxygen and demonstrates that, under some conditions, a more complex model for oxidation of the flavin than was previously proposed is required to accommodate the spectral evidence (see P. Muller and M. Ahmad (2011) J. Biol.	Oxygen	110-116	cryptochrome 1	Arabidopsis thaliana	83-96
12569620-8	2003	This technique modifies a diffusion-dominant gel ECM into a porous matrix with diffusive and convective flows that mutually transport O(2) through the ECMs.	Oxygen	134-138	multimerin 1	Homo sapiens	49-52
26096068-4	2015	LMP1 also increases the phosphorylation of PKM2, LDHA, and FGFR1, as well as the expression of PDHK1, FGFR1, c-Myc, and HIF-1alpha, regardless of oxygen availability.	Oxygen	146-152	PDZ and LIM domain 7	Homo sapiens	0-4
26853328-1	2016	To test the hypotheses that erythropoietin (rhuEPO) treatment increases systemic hematocrit, maximal O2 uptake (VO2max, by elevated perfusive and diffusive O2 conductances) and performance five female horses (4-13 years) received 15 IU/kg rhuEPO (erythropoietin) three times per week for three weeks.	Oxygen	101-103	erythropoietin	Equus caballus	28-42
26853328-1	2016	To test the hypotheses that erythropoietin (rhuEPO) treatment increases systemic hematocrit, maximal O2 uptake (VO2max, by elevated perfusive and diffusive O2 conductances) and performance five female horses (4-13 years) received 15 IU/kg rhuEPO (erythropoietin) three times per week for three weeks.	Oxygen	113-115	erythropoietin	Equus caballus	28-42
26853328-6	2016	EPO elevated VO2max by 20% from 25.7 +- 1.7 to 30.9 +- 3.4 L/min (P&lt;0.05) via a 17% increase in arterial O2 content and 18% greater arteriovenous O2 difference in the face of an unchanged cardiac output.	Oxygen	14-16	erythropoietin	Equus caballus	0-3
26853328-6	2016	EPO elevated VO2max by 20% from 25.7 +- 1.7 to 30.9 +- 3.4 L/min (P&lt;0.05) via a 17% increase in arterial O2 content and 18% greater arteriovenous O2 difference in the face of an unchanged cardiac output.	Oxygen	108-110	erythropoietin	Equus caballus	0-3
26853328-7	2016	To achieve the greater VO2max after EPO, diffusive O2 conductance increased ~ 30% (from 580 +- 76 to 752 +- 166 mL O2/mmHg/min, P&lt;0.05) which was substantially greater than the elevation of perfusive O2 conductance.	Oxygen	24-26	erythropoietin	Equus caballus	36-39
26853328-7	2016	To achieve the greater VO2max after EPO, diffusive O2 conductance increased ~ 30% (from 580 +- 76 to 752 +- 166 mL O2/mmHg/min, P&lt;0.05) which was substantially greater than the elevation of perfusive O2 conductance.	Oxygen	51-53	erythropoietin	Equus caballus	36-39
26853328-7	2016	To achieve the greater VO2max after EPO, diffusive O2 conductance increased ~ 30% (from 580 +- 76 to 752 +- 166 mL O2/mmHg/min, P&lt;0.05) which was substantially greater than the elevation of perfusive O2 conductance.	Oxygen	51-53	erythropoietin	Equus caballus	36-39
26853328-9	2016	We conclude that EPO substantially increases VO2max and performance in the splenectomized horse via improved perfusive and diffusive O2 transport.	Oxygen	46-48	erythropoietin	Equus caballus	17-20
26891117-4	2016	Birth into low (12%) or high (&gt;=60%) oxygen stimulated expansion of AEC2s through self-renewal and differentiation of the airway Scgb1a1 + lineage.	Oxygen	40-46	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	132-139
26239779-1	2015	Low oxygen availability is known to activate the hypoxia-inducible factor-1alpha (HIF-1alpha) pathway, which is involved in the impairment of fracture healing.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	49-80
26239779-1	2015	Low oxygen availability is known to activate the hypoxia-inducible factor-1alpha (HIF-1alpha) pathway, which is involved in the impairment of fracture healing.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	82-92
26004619-0	2015	Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.	Oxygen	66-72	growth differentiation factor 15	Homo sapiens	8-13
26004619-0	2015	Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.	Oxygen	66-72	growth differentiation factor 15	Homo sapiens	15-51
26004619-4	2015	We tested the hypothesis that GDF15 will be induced in vitro, in a model of pulmonary oxygen toxicity, and will play a critical role in decreasing cell death and oxidative stress.	Oxygen	86-92	growth differentiation factor 15	Homo sapiens	30-35
27295199-8	2016	Regarding physiological parameters, two (LMP vs. HMP) x three (BASE, AT, REC) repeated measures ANOVAs revealed no significant baseline differences but a significant higher order interaction indicating that in comparison to LMP, individuals in the HMP condition had significantly higher vasomotor tone and myocardial oxygen consumption but not BRS.	Oxygen	317-323	inner membrane mitochondrial protein	Homo sapiens	248-251
12569620-9	2003	Although tortuous pathways increase the porous ECM"s overall effective length of O(2) travel, the decreased transport resistances of these pathways allow O(2) to permeate more effectively into the ECMs.	Oxygen	81-85	multimerin 1	Homo sapiens	47-50
12569620-9	2003	Although tortuous pathways increase the porous ECM"s overall effective length of O(2) travel, the decreased transport resistances of these pathways allow O(2) to permeate more effectively into the ECMs.	Oxygen	154-158	multimerin 1	Homo sapiens	47-50
12569620-10	2003	Furthermore, because the HF design employs convective flow on both its inner and outer ECM surfaces, greater control of O(2) transport through its ECM is predicted, as compared with the single O(2) source inputs of the flat plate and spheroid systems.	Oxygen	120-124	multimerin 1	Homo sapiens	147-150
27071413-3	2016	Our previous report using this oximetry concluded that fetal head tissue oxygen saturation (StO 2 StO2 ) correlated with umbilical cord artery blood pH.	Oxygen	73-79	16 steroid alpha-hydroxylase 2	Mus musculus	98-102
26394398-7	2015	Mice devoid of Gpr116 developed an anatomically normal and largely functional vascular network, surprisingly exhibited an attenuated pathological retinal vascular response in a model of oxygen-induced retinopathy.	Oxygen	186-192	adhesion G protein-coupled receptor F5	Mus musculus	15-21
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	Oxygen	72-78	transcription factor Dp-2	Homo sapiens	20-23
26967059-3	2016	In this report we demonstrate that Rab25 regulates HIF-1alpha protein expression in an oxygen independent manner in a panel of cancer cell lines.	Oxygen	87-93	RAB25, member RAS oncogene family	Mus musculus	35-40
25500545-5	2015	We found that RSUME is expressed in human VHL tumors (renal clear-cell carcinoma (RCC), pheochromocytoma and hemangioblastoma) and by overexpressing or silencing RSUME in a pVHL-HIF-oxygen-dependent degradation stability reporter assay, we determined that RSUME is necessary for the loss of function of type 2 pVHL mutants.	Oxygen	182-188	RWD domain containing 3	Homo sapiens	14-19
12620871-5	2003	The expression of the PCS(At) gene was demonstrated in free-living cells under low-oxygen conditions.	Oxygen	83-89	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	22-25
26305952-7	2015	Steady-state levels of ATP, O2 consumption, mtDNA, and mitochondrial mass were also reduced in primary hepatocytes from CCl4-treated KO mice.	Oxygen	28-30	chemokine (C-C motif) ligand 4	Mus musculus	120-124
27064409-5	2016	Despite this reduction, oxygen consumption is only weakly reduced, suggesting that mitochondria of miro-1 mutants are more active than wild-type mitochondria.	Oxygen	24-30	Mitochondrial Rho GTPase 1	Caenorhabditis elegans	99-105
12574638-2	2003	The monoclinic (P2(1)/c) structure consists of perovskite-like slabs of vertex-sharing TiO(6) octahedra, which are separated by additional oxygen layers.	Oxygen	139-145	H3 histone pseudogene 16	Homo sapiens	16-23
26854136-10	2016	Levels of ROS, Bax, caspase-3 and BACE were increased, whereas expression of Bcl-2 was decreased, in cells treated with 95% oxygen plus 2.4% isoflurane compared with the control and 2.4% isoflurane plus air groups.	Oxygen	124-130	beta-secretase 1	Rattus norvegicus	34-38
26873920-2	2016	We designed experiments in fetal sheep with placental insufficiency and restricted growth to determine basal and insulin-stimulated myocardial glucose and oxygen metabolism and test the hypothesis that myocardial insulin sensitivity would be increased in the IUGR heart.	Oxygen	155-161	LOC105613195	Ovis aries	113-120
26444194-5	2015	Increase of the activity of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in leaves of the treated plants efficiently scavenged active oxygen species and resulted in the maintenance of photosynthetic membranes and reduction of malondealdehyde.	Oxygen	147-153	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	59-79
26444194-5	2015	Increase of the activity of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in leaves of the treated plants efficiently scavenged active oxygen species and resulted in the maintenance of photosynthetic membranes and reduction of malondealdehyde.	Oxygen	147-153	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	81-84
26873920-13	2016	These novel results demonstrate that the fetal heart exposed to nutrient and oxygen deprivation from placental insufficiency appears to maintain myocardial energy supply in the IUGR condition via increased glucose uptake and metabolic response to insulin, which support myocardial function and growth.	Oxygen	77-83	LOC105613195	Ovis aries	247-254
12531954-2	2003	OBJECTIVE: To investigate whether CSF hydrodynamic manipulation has an impact on biochemical markers related to ischaemia, brain tissue oxygen tension (PtiO(2)), and intracranial pressure.	Oxygen	136-142	colony stimulating factor 2	Homo sapiens	34-37
26063804-6	2015	However, after reconstituting isolated AIF or AMID into bacterial or mitochondrial membranes, N-terminally tagged AIF and AMID displayed substantial NADH:O2 activities and supported NADH-linked proton pumping activities in the host membranes almost as efficiently as Ndi1.	Oxygen	154-156	apoptosis inducing factor mitochondria associated 1	Homo sapiens	39-42
26063804-6	2015	However, after reconstituting isolated AIF or AMID into bacterial or mitochondrial membranes, N-terminally tagged AIF and AMID displayed substantial NADH:O2 activities and supported NADH-linked proton pumping activities in the host membranes almost as efficiently as Ndi1.	Oxygen	154-156	apoptosis inducing factor mitochondria associated 1	Homo sapiens	114-117
26063804-9	2015	In contrast, C-terminally tagged AIF and NADH-binding site mutants of N-terminally tagged AIF and AMID failed to show both NADH:O2 activity and the growth-enhancing effect.	Oxygen	128-130	apoptosis inducing factor mitochondria associated 1	Homo sapiens	90-93
25966616-0	2015	Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation.	Oxygen	136-142	gap junction protein, delta 2	Rattus norvegicus	79-90
26920732-3	2016	Hypoxia inducible factor-1 alpha is a well-known transcription factor which robustly induced during hypoxia and an essential factor for adaptation under lower oxygen tension.	Oxygen	159-165	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-32
26962451-11	2016	Adaptations in PMN gene expression in OVE + SM cows associated with the lower SCC were gradual increases from -10 to 21 d in genes that facilitate migration into inflammatory sites (SELL, ITGAM), enzymes essential for reducing reactive oxygen metabolites (SOD1, SOD2), and a transcription factor(s) required for controlling PMN development (RXRA).	Oxygen	236-242	L-selectin	Bos taurus	182-186
26865461-7	2016	Here, we describe the role exerted by GPCR-mediated signaling in low oxygen conditions, discussing, in particular, the involvement of GPER by a hypoxic microenvironment.	Oxygen	69-75	G protein-coupled estrogen receptor 1	Homo sapiens	134-138
25929785-5	2015	Hypoxia (1% O2) did not modify cytotoxicity, but decreasing O2 tensions during CTL and CD8(+) tumor-infiltrating lymphocyte reactivation dose-dependently decreased proliferation, induced secretion of the immunosuppressive cytokine IL-10, and upregulated the expression of CD137 (4-1BB) and CD25.	Oxygen	60-62	interleukin 2 receptor, alpha chain	Mus musculus	290-294
12505988-9	2003	In MTF-1 mutants, copper depletion prevents metamorphosis and dramatically extends larval development/lifespan from normally 4-5 days to as many as 32 days, possibly reflecting the effects of impaired oxygen metabolism.	Oxygen	201-207	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	3-8
26063773-6	2015	Analyses of blood oxygen level-dependent signals revealed that task-responsive voxels in anatomically defined CA1, CA23/dentate gyrus, and perirhinal cortex were more active when expectations were violated than when confirmed.	Oxygen	18-24	carbonic anhydrase 1	Homo sapiens	110-113
26760116-0	2016	Low Oxygen Tension Modulates the Insulin-Like Growth Factor-1 or -2 Signaling via Both Insulin-Like Growth Factor-1 Receptor and Insulin Receptor to Maintain Stem Cell Identity in Placental Mesenchymal Stem Cells.	Oxygen	4-10	insulin like growth factor 1 receptor	Homo sapiens	87-124
26760116-9	2016	This IGF/low oxygen tension-mediated proliferation was receptor dependent because neutralization of the IGF-1R inhibited PMSC proliferation in the presence of IGF-1 and the IR in presence of IGF-2.	Oxygen	13-19	insulin like growth factor 1 receptor	Homo sapiens	104-110
26760116-11	2016	We conclude that low-oxygen tension can modify the IGF-1 or IGF-2 signaling via the IGF-1R and IR in PMSCs.	Oxygen	21-27	insulin like growth factor 1 receptor	Homo sapiens	84-90
25970707-6	2015	We found that the rise in oxygen concentration reduced the secretion of elastin from DA SMC.	Oxygen	26-32	elastin	Rattus norvegicus	72-79
14562752-0	2003	Effect of myoglobin inactivation on intracellular gradients of NADH fluorescence at critical mitochondrial oxygen supply.	Oxygen	107-113	myoglobin	Homo sapiens	10-19
25970707-8	2015	CONCLUSIONS: Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.	Oxygen	131-137	elastin	Rattus norvegicus	177-184
25970707-8	2015	CONCLUSIONS: Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.	Oxygen	131-137	elastin	Rattus norvegicus	177-184
25970707-8	2015	CONCLUSIONS: Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.	Oxygen	223-229	elastin	Rattus norvegicus	24-31
25970707-8	2015	CONCLUSIONS: Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.	Oxygen	223-229	elastin	Rattus norvegicus	177-184
25970707-8	2015	CONCLUSIONS: Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structural remodeling after birth.	Oxygen	223-229	elastin	Rattus norvegicus	177-184
26740484-6	2016	Supplemental oxygen exposure was calculated as the area under the dosextime curve for oxygen administration over the first 12 h, and then assessed for its association with cTnI/CK release using multivariable linear regression.	Oxygen	13-19	troponin I3, cardiac type	Homo sapiens	172-176
26740484-8	2016	After adjustment for potential confounders, every 100 L increase in oxygen exposure in the first 12 h was associated with a 1.4% (95% CI 0.6% to 2.2%, p&lt;0.001) and 1.2% (95% CI 0.7% to 1.8%, p&lt;0.001) increase in the mean peak cTnI and CK, respectively.	Oxygen	68-74	troponin I3, cardiac type	Homo sapiens	232-236
26740484-9	2016	Excluding patients who developed cardiogenic shock, recurrent myocardial infarction or desaturations (SpO2&lt;94%) during admission, every 100 L increase in oxygen exposure was associated with a 1.2% (95% CI 0.2% to 2.1%, p=0.01) and 1.0% (95% CI 0.3% to 1.7%, p=0.003) increase in the mean peak cTnI and CK, respectively.	Oxygen	157-163	troponin I3, cardiac type	Homo sapiens	296-300
26740484-10	2016	The median supplemental oxygen exposure of 1746 L would result in a 21% (95% CI 3% to 37%) increase in infarct size according to the cTnI profile.	Oxygen	24-30	troponin I3, cardiac type	Homo sapiens	133-137
26740484-11	2016	CONCLUSIONS: Supplemental oxygen exposure in the first 12 h after STEMI was associated with a clinically significant increase in cTnI and CK release.	Oxygen	26-32	troponin I3, cardiac type	Homo sapiens	129-133
12573617-0	2003	Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.	Oxygen	88-94	vascular endothelial growth factor A	Rattus norvegicus	56-60
26677131-2	2016	By preventing the irreversible fusion and aggregation during the high-temperature pyrolysis step with this protection strategy, the Co,N-CNF exhibits comparable oxygen reduction reaction (ORR) catalytic activity to that of commercial Pt catalysts with the same loading.	Oxygen	161-167	NPHS1 adhesion molecule, nephrin	Homo sapiens	137-140
26089197-1	2015	Carboxylate-bridged Mn(II)-Ca(II) complexes are potentially relevant for mimicking the first stages of the Oxygen-Evolving Complex (OEC) assembly process.	Oxygen	107-113	carbonic anhydrase 2	Homo sapiens	27-33
26148216-2	2015	Furthermore, an appropriate number of oxygen vacancies were introduced into the oxide during annealing at 400  C in ambient N2, making both SnO and SnO2 favorable for current conduction.	Oxygen	38-44	strawberry notch homolog 2	Homo sapiens	140-143
25997945-2	2015	In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine deaminase (ADA).	Oxygen	15-21	adenosine deaminase	Rattus norvegicus	151-170
26774962-0	2016	Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.	Oxygen	30-36	egl-9 family hypoxia-inducible factor 2	Mus musculus	44-48
26774962-4	2016	Instead, PHD1(-/-) neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism.	Oxygen	50-56	egl-9 family hypoxia-inducible factor 2	Mus musculus	9-13
12573617-6	2003	We asked whether an intra-arterial injection of AAV-VEGF(165) normalizes muscle oxygen tension by increasing skeletal muscle oxygen tension, and promotes arteriogenesis and angiogenesis in a rat model of severe hindlimb ischemia.	Oxygen	80-86	vascular endothelial growth factor A	Rattus norvegicus	52-56
26784545-4	2016	Evaluation of a murine liver colonization model revealed that PKLR promotes cell survival in the tumor core during conditions of high cell density and oxygen deprivation by increasing glutathione, the primary endogenous antioxidant.	Oxygen	151-157	pyruvate kinase liver and red blood cell	Mus musculus	62-66
26136527-0	2015	Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.	Oxygen	98-100	elastin	Rattus norvegicus	28-35
12573617-6	2003	We asked whether an intra-arterial injection of AAV-VEGF(165) normalizes muscle oxygen tension by increasing skeletal muscle oxygen tension, and promotes arteriogenesis and angiogenesis in a rat model of severe hindlimb ischemia.	Oxygen	125-131	vascular endothelial growth factor A	Rattus norvegicus	52-56
26136527-4	2015	Exposure to 60% O2 was associated with increased lung contents of neutrophil elastase and alpha-elastin, a marker of denatured elastin, and a decrease in elastin fiber density.	Oxygen	16-18	elastin	Rattus norvegicus	96-103
26136527-4	2015	Exposure to 60% O2 was associated with increased lung contents of neutrophil elastase and alpha-elastin, a marker of denatured elastin, and a decrease in elastin fiber density.	Oxygen	16-18	elastin	Rattus norvegicus	127-134
12573617-7	2003	We found that AAV-VEGF treatment normalized muscle oxygen tension in the ischemic limb.	Oxygen	51-57	vascular endothelial growth factor A	Rattus norvegicus	18-22
26136527-4	2015	Exposure to 60% O2 was associated with increased lung contents of neutrophil elastase and alpha-elastin, a marker of denatured elastin, and a decrease in elastin fiber density.	Oxygen	16-18	elastin	Rattus norvegicus	127-134
26136527-5	2015	This led us to speculate that neutrophil elastase-induced elastin fragments were the chemokines that led to a LM influx into the 60% O2-exposed lung.	Oxygen	133-135	elastin	Rattus norvegicus	58-65
12573617-10	2003	We conclude that intra-arterial AAV-mediated gene transfer of AAV-VEGF(165) normalizes muscle oxygen tension and leads to arteriogenesis in rats with severe hindlimb ischemia.	Oxygen	94-100	vascular endothelial growth factor A	Rattus norvegicus	66-70
26136527-7	2015	Sivelestat also attenuated the 60% O2-induced decrease in elastin fiber density.	Oxygen	35-37	elastin	Rattus norvegicus	58-65
26364050-3	2016	Whereas oxygen and glucose deprivation increased [(3)H]glycine release, its uptake was reduced suggesting that energy deficiency shifts glycine transporter type-1 operation from normal to reverse mode.	Oxygen	8-14	solute carrier family 6 member 9	Rattus norvegicus	136-162
26364050-4	2016	The increased release of [(3)H]glycine evoked by oxygen and glucose deprivation was suspended by addition of the non-competitive glycine transporter type-1 inhibitor NFPS and the competitive inhibitor ACPPB further suggesting the involvement of this transporter in the mediation of [(3)H]glycine release.	Oxygen	49-55	solute carrier family 6 member 9	Rattus norvegicus	129-155
26136527-8	2015	Daily injections of pups with an antibody to alpha-elastin prevented the 60% O2-dependent LM influx, impaired alveologenesis, and impaired small vessel formation.	Oxygen	77-79	elastin	Rattus norvegicus	51-58
12699774-3	2003	We used organotypic hippocampal cultures to investigate the involvement of heat shock protein (HSP) 27 in preconditioning to oxygen and glucose deprivation.	Oxygen	125-131	heat shock protein family B (small) member 1	Homo sapiens	75-102
25850028-7	2015	Mice treated with Ad-SOCS-1 had enhanced survival in 100% oxygen compared to Ad-GFP-administered mice.	Oxygen	58-64	suppressor of cytokine signaling 1	Mus musculus	21-27
26750474-3	2016	A mild O2 pretreatment (at 80  C) can activate the catalyst, and the addition of reductive gases (CO or H2) can enhance the activation effects of O2 pretreatment via a redox cycle in which CO could reduce the surface of CeO2 to produce oxygen vacancies-which then adsorb and activate O2 to produce more active oxygen species.	Oxygen	146-148	relaxin 2	Homo sapiens	98-106
26750474-3	2016	A mild O2 pretreatment (at 80  C) can activate the catalyst, and the addition of reductive gases (CO or H2) can enhance the activation effects of O2 pretreatment via a redox cycle in which CO could reduce the surface of CeO2 to produce oxygen vacancies-which then adsorb and activate O2 to produce more active oxygen species.	Oxygen	236-242	relaxin 2	Homo sapiens	98-106
26750474-3	2016	A mild O2 pretreatment (at 80  C) can activate the catalyst, and the addition of reductive gases (CO or H2) can enhance the activation effects of O2 pretreatment via a redox cycle in which CO could reduce the surface of CeO2 to produce oxygen vacancies-which then adsorb and activate O2 to produce more active oxygen species.	Oxygen	146-148	relaxin 2	Homo sapiens	98-106
26750474-3	2016	A mild O2 pretreatment (at 80  C) can activate the catalyst, and the addition of reductive gases (CO or H2) can enhance the activation effects of O2 pretreatment via a redox cycle in which CO could reduce the surface of CeO2 to produce oxygen vacancies-which then adsorb and activate O2 to produce more active oxygen species.	Oxygen	310-316	relaxin 2	Homo sapiens	98-106
26207311-8	2015	Five percent oxygen significantly increased the number of CD44+ LG-MSC.	Oxygen	13-19	CD44 antigen	Mus musculus	58-62
12699774-6	2003	Treatments with 5 or 10 min of oxygen and glucose deprivation (OGD) or 1- microM N-methyl-D-aspartate (NMDA) induced tolerance to 40 min of OGD associated with an increase in HSP27 immunocontent and phosphorylation.	Oxygen	31-37	heat shock protein family B (small) member 1	Homo sapiens	175-180
26207311-12	2015	Also, an increased number of LG-MSC expressing CD44 was observed under low oxygen, which might be a valuable marker to identify a potent MSC subpopulation.	Oxygen	75-81	CD44 antigen	Mus musculus	47-51
12925305-7	2003	In tumor tissue, Bcl-2 expression was highest in the 15-CO offspring, and Bak expression was significantly higher in rats exposed to OO.	Oxygen	133-135	BCL2-antagonist/killer 1	Rattus norvegicus	74-77
26627829-8	2016	In fibroblasts, we observed that TSPO deficiency decreased the oxygen consumption rate and mitochondrial membrane potential (DeltaPsim) indicative of a cellular metabolic shift, without a negative impact on porphyrin biosynthetic capability.	Oxygen	63-69	translocator protein	Homo sapiens	33-37
12470866-3	2002	EPO treated cultured slices (40 units/ml for 48 h) showed significantly increased FP during and following oxygen and glucose deprivation compared with untreated control slices.	Oxygen	106-112	erythropoietin	Rattus norvegicus	0-3
27119348-8	2016	Experimental inhibition of p66shc by siRNA suppressed GA-induced increase of ROS, decrease of oxygen consumption rate, MMP and cell viability, whilst suppressing GA-induced increase of apoptosis.	Oxygen	94-100	src homology 2 domain-containing transforming protein C1	Mus musculus	27-33
25757454-8	2016	Only MMP-9 was significantly correlated with the severity of the disease, expressed as AHI, with the oxygen desaturation index and also with the mean oxygen saturation.	Oxygen	101-107	matrix metallopeptidase 9	Homo sapiens	5-10
26297325-1	2016	PURPOSE: This study determined the effects of pre-exercise sodium bicarbonate ingestion (ALK) on changes in oxygen uptake (VO2) at the end of a supramaximal exercise test (SXT).	Oxygen	108-114	ALK receptor tyrosine kinase	Homo sapiens	89-92
25693838-4	2015	Chemical inhibition also reduces basal oxygen consumption and fatty acid synthesis, showing that downstream metabolic function is reliant on ASCT2-mediated glutamine uptake.	Oxygen	39-45	solute carrier family 1 member 5	Homo sapiens	141-146
25996254-1	2015	L-Tryptophan 2,3-dioxygenase (TDO) is a protoheme-containing enzyme that catalyzes the production of N-formylkynurenine by inserting O2 into the pyrrole ring of L-tryptophan.	Oxygen	133-135	tryptophan 2,3-dioxygenase	Homo sapiens	0-28
25996254-1	2015	L-Tryptophan 2,3-dioxygenase (TDO) is a protoheme-containing enzyme that catalyzes the production of N-formylkynurenine by inserting O2 into the pyrrole ring of L-tryptophan.	Oxygen	133-135	tryptophan 2,3-dioxygenase	Homo sapiens	30-33
25996254-3	2015	In this study, the O2 insertion reaction catalyzed by Pseudomonas TDO (PaTDO) was examined using a heme-modification approach, which allowed us to draw a quantitative correlation between the inductive electronic effects of the heme substituents and the substituent-induced changes in the functional behaviors of the ferrous-oxy form.	Oxygen	19-21	tryptophan 2,3-dioxygenase	Homo sapiens	66-69
25939391-3	2015	In oxidations of N,N-dimethylaniline and its analogues, adding Zn(OTf)2 to the [Fe(TPA)Cl2]Cl catalyst can trigger the amine oxidation with dioxygen, whereas [Fe(TPA)Cl2]Cl alone is very sluggish.	Oxygen	140-148	POU class 2 homeobox 2	Homo sapiens	66-71
12480817-4	2002	In the present study, electron spin resonance spectroscopy is utilized to demonstrate that VEGF stimulates O2*- production, which is inhibited by the NAD(P)H oxidase inhibitor, diphenylene iodonium, as well as by overexpression of dominant-negative Rac1 (N17Rac1) and transfection of gp91(phox) antisense oligonucleotides in human umbilical vein endothelial cells (ECs).	Oxygen	107-109	paired Ig-like receptor B	Mus musculus	284-288
25519745-1	2015	The new research tried to improve the distribution of molecular weight of Hb-based oxygen carriers (HBOC), a bottleneck of glutaraldehyde (GDA)-polymerization process.	Oxygen	83-89	guanine deaminase	Homo sapiens	139-142
26604221-0	2016	LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.	Oxygen	12-18	lysocardiolipin acyltransferase 1	Homo sapiens	98-104
27194935-6	2016	Methionines on residues 215 (215), 438 (438), 853 (851), 856 (854), 1071 (1069), and 1106 (1104) of myosin-1 (myosin-4) were oxidized by the addition of oxygen.	Oxygen	153-159	myosin heavy chain 1	Homo sapiens	100-108
12370489-3	2002	Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf-1 mediated caspase-9 activation.	Oxygen	27-33	caspase 9	Homo sapiens	109-118
25936780-2	2015	We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3).	Oxygen	80-86	NDRG family member 3	Homo sapiens	140-145
25936780-3	2015	Oxygen negatively regulates NDRG3 expression at the protein level via the PHD2/VHL system, whereas lactate, produced in excess under prolonged hypoxia, blocks its proteasomal degradation by binding to NDRG3.	Oxygen	0-6	NDRG family member 3	Homo sapiens	28-33
27563172-4	2016	Here we analysed recombinant expressed human TDO and ex vivo murine TDO functions under different oxygen conditions and show that TDO-induced restrictions of clinically relevant pathogens (bacteria, parasites) and of T cell proliferation are abrogated under hypoxic conditions.	Oxygen	98-104	tryptophan 2,3-dioxygenase	Mus musculus	68-71
12370489-5	2002	Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation.	Oxygen	144-150	caspase 9	Homo sapiens	107-116
27563172-4	2016	Here we analysed recombinant expressed human TDO and ex vivo murine TDO functions under different oxygen conditions and show that TDO-induced restrictions of clinically relevant pathogens (bacteria, parasites) and of T cell proliferation are abrogated under hypoxic conditions.	Oxygen	98-104	tryptophan 2,3-dioxygenase	Mus musculus	68-71
12559405-4	2002	Metabolic rate was not reduced when we fed wild-type worms reduced food and was up-regulated in the eat-2 mutants in liquid culture, as assessed by oxygen consumption rate and heat production.	Oxygen	148-154	Neuronal acetylcholine receptor subunit eat-2	Caenorhabditis elegans	100-105
27161009-1	2016	An overview of anticancer active (arene)ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review.	Oxygen	148-154	period circadian regulator 2	Homo sapiens	79-87
12444653-1	2002	Classical and free energy barriers for oxygen atom transfer from C4a-hydroperoxyflavin to dimethyl sulfide.	Oxygen	39-45	complement C4A (Rodgers blood group)	Homo sapiens	65-68
25421206-3	2016	Using a new PINK1 knockout (PINK1 KO) rat model, we found altered brain metabolomic markers using magnetic resonance spectroscopy, identified changes in mitochondrial pathways with quantitative proteomics using sequential window acquisition of all theoretical spectra (SWATH) mass spectrometry, and demonstrated mitochondrial functional alterations through measurement of oxygen consumption and acidification rates.	Oxygen	372-378	PTEN induced kinase 1	Rattus norvegicus	12-17
26546081-3	2016	Restored FBP1 expression inhibited glucose uptake and lactate production, but induced oxygen consumption.	Oxygen	86-92	fructose-bisphosphatase 1	Homo sapiens	9-13
12444653-8	2002	Classical energy barriers for oxygen atom transfer from neutral and ion-paired forms of C4a-hydroperoxyflavin to dimethyl sulfide are predicted to differ by a small margin, suggesting that proton distribution exerts a relatively small influence on the reactivity of alkyl hydroperoxides.	Oxygen	30-36	complement C4A (Rodgers blood group)	Homo sapiens	88-91
12215428-4	2002	Exposure to NO and O2 induced a synergistic cytotoxicity, accompanied with apoptotic characteristics, including elevated caspase-3-like activity, Annexin V incorporation, and nuclear condensation.	Oxygen	19-21	annexin A5	Homo sapiens	146-155
12491790-6	2002	A decreased rate of SSAO inhibition under N2 atmosphere to that obtained under O2 was produced after 2-BEA treatment, suggesting that oxidised intermediate was necessary for its inhibition.	Oxygen	79-81	amine oxidase copper containing 2	Homo sapiens	20-24
28132465-2	2016	AOX transfers electrons from reduced ubiquinone to oxygen omitting two coupling places thus lowering energetic efficiency of respiration.	Oxygen	51-57	acyl-CoA oxidase 1	Homo sapiens	0-3
26646468-3	2015	Experimental results revealed that the alachlor oxidation enhancement in the syn-FeS2 Fenton system was attributed to the molecular oxygen activation induced by more surface-bound ferrous ions on syn-FeS2.	Oxygen	132-138	synemin	Homo sapiens	77-80
26646468-3	2015	Experimental results revealed that the alachlor oxidation enhancement in the syn-FeS2 Fenton system was attributed to the molecular oxygen activation induced by more surface-bound ferrous ions on syn-FeS2.	Oxygen	132-138	synemin	Homo sapiens	196-199
26646468-4	2015	The molecular oxygen activation process could generate superoxide anions to accelerate the Fe(II)/Fe(III) cycle on the syn-FeS2 surface, which favored the H2O2 decomposition to generate more hydroxyl radicals for the alachlor oxidation.	Oxygen	14-20	synemin	Homo sapiens	119-122
26663343-0	2015	Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.	Oxygen	0-8	lysine demethylase 4A	Homo sapiens	59-65
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Oxygen	251-258	teashirt zinc finger homeobox 1	Homo sapiens	84-87
12702396-6	2002	Trichloroacetic acid, oxygen, and hydrogen peroxide were electrochemically catalyzed by [AQ/Mb](6) films with significant lowering of reduction overpotential.	Oxygen	22-28	myoglobin	Homo sapiens	92-94
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Oxygen	251-258	teashirt zinc finger homeobox 1	Homo sapiens	136-139
26964208-0	2015	[Study on RBC Oxygen-Carrying Function with the Incubation Time].	Oxygen	14-20	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	10-13
26964208-2	2015	But it has not yet been reported about any studies on the oxygen-carrying function of individual living RBC in vitro with the incubation time.	Oxygen	58-64	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	104-107
12354567-1	2002	We have previously shown the involvement of Na(+) channel as well as N-type and P/Q-type Ca(2+) channels in the oxygen and glucose deprivation-induced injury in rat cerebrocortical slices.	Oxygen	112-118	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	44-57
26964208-6	2015	The conclusion not only provides a multi-level characteristic parameter from a single living cell for the study of RBC oxygen-carrying function in vitro, but also the potential research ideas for the screening of the active component, the evaluation of drug efficacy and toxicity for RBC in vitro.	Oxygen	119-125	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	115-118
26964208-6	2015	The conclusion not only provides a multi-level characteristic parameter from a single living cell for the study of RBC oxygen-carrying function in vitro, but also the potential research ideas for the screening of the active component, the evaluation of drug efficacy and toxicity for RBC in vitro.	Oxygen	119-125	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	284-287
26241463-5	2015	Myosin heavy chain (MHC) cross-linking, another marker of protein oxidation, was greater in MAP with 80% oxygen than 0% and 20% oxygen.	Oxygen	105-111	major histocompatibility complex, class I, C	Homo sapiens	0-18
12225954-6	2002	Exposure to 100% oxygen for 72 h resulted in a significant decrease in EC-SOD levels in the lungs and bronchoalveolar lavage fluid of mice.	Oxygen	17-23	superoxide dismutase 3, extracellular	Mus musculus	71-77
26241463-5	2015	Myosin heavy chain (MHC) cross-linking, another marker of protein oxidation, was greater in MAP with 80% oxygen than 0% and 20% oxygen.	Oxygen	105-111	major histocompatibility complex, class I, C	Homo sapiens	20-23
26241463-5	2015	Myosin heavy chain (MHC) cross-linking, another marker of protein oxidation, was greater in MAP with 80% oxygen than 0% and 20% oxygen.	Oxygen	128-134	major histocompatibility complex, class I, C	Homo sapiens	0-18
26241463-5	2015	Myosin heavy chain (MHC) cross-linking, another marker of protein oxidation, was greater in MAP with 80% oxygen than 0% and 20% oxygen.	Oxygen	128-134	major histocompatibility complex, class I, C	Homo sapiens	20-23
12238567-4	2002	After 56 hr of hyperoxia, pulmonary neutrophils were lower in the O2/endotoxin group compared to O2 controls as measured by myeloperoxidase in lung homogenates and neutrophil counts in bronchoalveolar lavage fluid.	Oxygen	66-68	myeloperoxidase	Rattus norvegicus	124-139
26613462-5	2015	We also show for the first time that the spin state of single TM atoms systematically varies with the coordination of neighboring nitrogen or oxygen atoms.	Oxygen	142-148	spindlin 1	Homo sapiens	41-45
27066567-1	2015	PNKP (polynucleotide kinase 3"-phosphatase, OMIM #605610) product is involved in the repair of strand breaks and base damage in the DNA molecule mainly caused by radical oxygen species.	Oxygen	170-176	polynucleotide kinase 3'-phosphatase	Homo sapiens	0-4
12235036-11	2002	O(2) sensing in EPO-producing cells of the kidney appears to be independent of the gp91(phox) and p47(phox) components of the phagocytic NADPH oxidase.	Oxygen	0-4	erythropoietin	Mus musculus	16-19
27066567-1	2015	PNKP (polynucleotide kinase 3"-phosphatase, OMIM #605610) product is involved in the repair of strand breaks and base damage in the DNA molecule mainly caused by radical oxygen species.	Oxygen	170-176	polynucleotide kinase 3'-phosphatase	Homo sapiens	6-42
12176051-1	2002	Members of the Quiescin-sulfhydryl oxidase (QSOX) family utilize a thioredoxin domain and a small FAD-binding domain homologous to the yeast ERV1p protein to oxidize sulfhydryl groups to disulfides with the reduction of oxygen to hydrogen peroxide.	Oxygen	220-226	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	141-146
26427992-4	2015	A computational search for low energy geometries revealed that the syn isomer favors a six-membered ring hydrogen bond to nitrogen and the anti isomer favors a five-membered ring hydrogen bond to oxygen.	Oxygen	196-202	synemin	Homo sapiens	67-70
26112987-4	2015	We assessed the mechanisms underlying effects of moderate hyperoxia (50% O2) on BDNF expression and secretion in developing human ASM.	Oxygen	73-75	brain derived neurotrophic factor	Homo sapiens	80-84
12213585-3	2002	We demonstrated that the regulation of glucagon receptor, insulin receptor and L-type pyruvate kinase (L-PK) gene expression in liver is dependent upon a cross-talk between oxygen and glucose.	Oxygen	173-179	glucagon receptor	Rattus norvegicus	39-56
26722464-4	2015	NO is synthesized by nitric oxide synthase (nNOS) from L-arginine and oxygen.	Oxygen	70-76	nitric oxide synthase 1	Rattus norvegicus	44-48
12213585-3	2002	We demonstrated that the regulation of glucagon receptor, insulin receptor and L-type pyruvate kinase (L-PK) gene expression in liver is dependent upon a cross-talk between oxygen and glucose.	Oxygen	173-179	pyruvate kinase L/R	Rattus norvegicus	79-101
12213585-3	2002	We demonstrated that the regulation of glucagon receptor, insulin receptor and L-type pyruvate kinase (L-PK) gene expression in liver is dependent upon a cross-talk between oxygen and glucose.	Oxygen	173-179	pyruvate kinase L/R	Rattus norvegicus	103-107
12213585-6	2002	It was demonstrated for the L-PK gene that the modulation by O2 of the glucose-dependent induction occured at the glucose-responsive element (Glc(PK)RE) in the L-PK gene promoter.	Oxygen	61-63	pyruvate kinase L/R	Rattus norvegicus	28-32
26366999-0	2015	IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway.	Oxygen	27-33	interleukin 10	Homo sapiens	0-5
26366999-2	2015	Here, we reported that IL-10, in a concentration-dependent manner, reduced neuronal apoptosis and increased neuronal survival in oxygen-glucose-deprived primary cortical neurons, producing an optimal protective effect at 20ng/ml.	Oxygen	129-135	interleukin 10	Homo sapiens	23-28
26366999-7	2015	These findings suggest that IL-10 provides neuroprotective effects by protecting neurites through PI3K/AKT signaling pathway in oxygen-glucose-deprived primary cortical neurons.	Oxygen	128-134	interleukin 10	Homo sapiens	28-33
26224005-7	2015	These experiments suggest a dependence on oxygen availability and metabolic substrates for SSC survival and suggest that Dnd1(Ter/+) SSCs may act as efficient sensors to detect subtle environmental changes that alter SSC fate.	Oxygen	42-48	DND microRNA-mediated repression inhibitor 1	Mus musculus	121-125
12213585-6	2002	It was demonstrated for the L-PK gene that the modulation by O2 of the glucose-dependent induction occured at the glucose-responsive element (Glc(PK)RE) in the L-PK gene promoter.	Oxygen	61-63	pyruvate kinase L/R	Rattus norvegicus	160-164
12440766-2	2002	Ceruloplasmin is an ancient multicopper dase evolved to insure a safe handling of oxygen in some metabolic pathways of vertebrates.	Oxygen	82-88	ceruloplasmin	Homo sapiens	0-13
26077311-5	2015	For maximal activity FGE requires an O2 concentration of 9% (105 muM).	Oxygen	37-39	sulfatase modifying factor 1	Homo sapiens	21-24
12198491-4	2002	The ATP-stimulated Lon protease may be an essential defence against the stress of life in an oxygen environment.	Oxygen	93-99	lon peptidase 1, mitochondrial	Homo sapiens	19-31
26077311-10	2015	The available data characterize eukaryotic FGE as a monooxygenase, in which Cys336/Cys341 disulfide bridge formation donates the electrons required to reduce one oxygen atom of O2 to water while the other oxygen atom oxidizes the CxPxR cysteine to FGly.	Oxygen	56-62	sulfatase modifying factor 1	Homo sapiens	43-46
26077311-10	2015	The available data characterize eukaryotic FGE as a monooxygenase, in which Cys336/Cys341 disulfide bridge formation donates the electrons required to reduce one oxygen atom of O2 to water while the other oxygen atom oxidizes the CxPxR cysteine to FGly.	Oxygen	177-179	sulfatase modifying factor 1	Homo sapiens	43-46
26077311-10	2015	The available data characterize eukaryotic FGE as a monooxygenase, in which Cys336/Cys341 disulfide bridge formation donates the electrons required to reduce one oxygen atom of O2 to water while the other oxygen atom oxidizes the CxPxR cysteine to FGly.	Oxygen	162-168	sulfatase modifying factor 1	Homo sapiens	43-46
12052835-8	2002	These findings demonstrate that disruption of Hsp90 function 1) promotes HIF-1 alpha degradation via a novel, oxygen-independent E3 ubiquitin ligase and 2) diminishes HIF-1 alpha transcriptional activity.	Oxygen	110-116	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-51
26628836-10	2015	Finally, the oxygen radical absorbance capacity (ORAC) in three different SGLT2 inhibitors was determined: remogliflozin, canagliflozin and dapagliflozin.	Oxygen	13-19	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	74-79
12236576-6	2002	The hematoporphyrin-myoglobin interaction causes oxygen release from the protein and it varies with the stoichiometric ratio of the porphyrin:protein.	Oxygen	49-55	myoglobin	Homo sapiens	20-29
26268898-0	2015	Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation.	Oxygen	33-39	lysophosphatidic acid receptor 1	Homo sapiens	58-62
25697776-7	2015	Supported by O2 diffusion simulations, these data describe the first enzymatically controlled O2 access into a flavoprotein active site, provide molecular-level understanding of Ero1alpha regulation and H2O2 production/detoxification, and establish the deleterious consequences of constitutive Ero1 activity.	Oxygen	13-15	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	178-187
25697776-7	2015	Supported by O2 diffusion simulations, these data describe the first enzymatically controlled O2 access into a flavoprotein active site, provide molecular-level understanding of Ero1alpha regulation and H2O2 production/detoxification, and establish the deleterious consequences of constitutive Ero1 activity.	Oxygen	94-96	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	178-187
26268898-7	2015	Structurally, LPA-type agonist via Carbonyl-oxygen/Lys39 interaction facilitated the formation of a hypothetical N-terminal cap tightly packed over LPA1 heptahelical bundle.	Oxygen	44-50	lysophosphatidic acid receptor 1	Homo sapiens	148-152
12112780-9	2002	TA MCP-1 but not IL-8 concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks postconceptional age.	Oxygen	83-89	C-C motif chemokine ligand 2	Homo sapiens	3-8
25888796-3	2015	Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha (PKGIalpha).	Oxygen	109-115	NADPH oxidase 4	Rattus norvegicus	154-171
25896762-0	2015	MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8/SVneo cell invasion by directly down regulating CXCL12 under low oxygen conditions.	Oxygen	129-135	microRNA 135b	Homo sapiens	0-13
25896762-4	2015	Culturing the extravillous trophoblast (EVT) cell line, HTR-8/SVneo, at 2% oxygen as compared to 20% oxygen suppressed trophoblast invasion that correlated with increased expression of microRNA-135b (miR-135b) and decreased expression of the its predicted target gene CXCL12.	Oxygen	101-107	microRNA 135b	Homo sapiens	185-198
26178625-4	2015	Co-CNF gives rise to a lower discharge polarization because of an enhanced oxygen reduction reaction activity compared to Co-free CNF.	Oxygen	75-81	NPHS1 adhesion molecule, nephrin	Homo sapiens	3-6
12126417-3	2002	Protonation on oxygen results in nucleophilic attack at the acyl carbon and gives C-2 products.	Oxygen	15-21	complement C2	Homo sapiens	82-85
26249166-4	2015	Erythrocytes from Ampd3(-/-) mice exhibited higher half-saturation pressure of oxygen (p50) and about 3-fold higher levels of ATP and ADP, while they maintained normal 2,3-bisphosphoglycerate (2,3-BPG), methemoglobin levels and intracellular pH.	Oxygen	79-85	adenosine monophosphate deaminase 3	Mus musculus	18-23
25896762-8	2015	Our results suggest that miR-135b and CXCL12 play important roles in modulating the EVT invasion under low oxygen conditions.	Oxygen	107-113	microRNA 135b	Homo sapiens	25-33
12112237-3	2002	The Hap1 transcription factor senses cellular heme status and increases expression of aerobic genes in response to oxygen.	Oxygen	115-121	Hap1p	Saccharomyces cerevisiae S288C	4-8
25959902-4	2015	Here we report the transient infrared spectrum of syn- and anti-CH3CHOO, produced from CH3CHI + O2 in a flow reactor, using a step-scan Fourier-transform spectrometer.	Oxygen	96-98	synemin	Homo sapiens	50-53
12132591-1	2002	Eukaryotic mitochondria are equipped with a complete thioredoxin system, composed of thioredoxin and thioredoxin reductase, which has been implicated in the protection against the reactive oxygen intermdiates generated during the respiratory process in this organelle.	Oxygen	189-195	thioredoxin	Homo sapiens	53-64
25638408-0	2015	PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy.	Oxygen	92-98	vascular endothelial growth factor A	Mus musculus	54-58
26441482-0	2015	Spin-labeled small unilamellar vesicles with the T1-sensitive saturation-recovery EPR display as an oxygen sensitive analyte for measurement of cellular respiration.	Oxygen	100-106	spindlin 1	Homo sapiens	0-4
26441482-5	2015	It was shown that this display (spin-lattice relaxation rate) is linear in oxygen partial pressure up to 100% air (159 mmHg).	Oxygen	75-81	spindlin 1	Homo sapiens	32-36
25913436-3	2015	Electrons are transferred from FADH2 in the catalytic flavodehydrogenase domain of CDH to haem b in a mobile cytochrome domain, which acts as a mediator and transfers electrons towards the active site of lytic polysaccharide mono-oxygenase to activate oxygen.	Oxygen	230-236	choline dehydrogenase	Homo sapiens	83-86
25934105-2	2015	The biosensor (poly(TTP)/GOx/GCE) showed a pair of redox peaks in 0.1 M phosphate buffer (pH 7.4) solution in the absence of oxygen the co-substrate of GOx.	Oxygen	125-131	hydroxyacid oxidase 1	Homo sapiens	25-28
25648081-9	2015	Compared with 20 % O2 (normoxia), 3 % O2 (hypoxia) inhibited cell proliferation, increased the intracellular calcium concentration, and induced protein expression of HIF-1alpha.	Oxygen	19-21	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	166-176
25648081-9	2015	Compared with 20 % O2 (normoxia), 3 % O2 (hypoxia) inhibited cell proliferation, increased the intracellular calcium concentration, and induced protein expression of HIF-1alpha.	Oxygen	38-40	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	166-176
25535214-3	2015	METHODS AND RESULTS: The myocardial oxygen consumption rate was assessed via a kmono index--the clearance rate constant of a mono-exponential function fitted to a C-11 acetate clearance curve.	Oxygen	36-42	RNA polymerase III subunit K	Homo sapiens	163-167
25934105-3	2015	In here, Poly(TTP)/GOx/GCE biosensor acts as the co-substrate instead of oxygen.	Oxygen	73-79	hydroxyacid oxidase 1	Homo sapiens	19-22
12132591-1	2002	Eukaryotic mitochondria are equipped with a complete thioredoxin system, composed of thioredoxin and thioredoxin reductase, which has been implicated in the protection against the reactive oxygen intermdiates generated during the respiratory process in this organelle.	Oxygen	189-195	thioredoxin	Homo sapiens	85-96
26191192-1	2015	This study aimed to investigate the anti-angiogenic effects of Celecoxib on the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible transcription factor 1alpha (HIF-1alpha) in a mouse model for oxygen-induced retinopathy (OIR).	Oxygen	220-226	vascular endothelial growth factor A	Mus musculus	94-128
12132591-1	2002	Eukaryotic mitochondria are equipped with a complete thioredoxin system, composed of thioredoxin and thioredoxin reductase, which has been implicated in the protection against the reactive oxygen intermdiates generated during the respiratory process in this organelle.	Oxygen	189-195	peroxiredoxin 5	Homo sapiens	101-122
12067982-8	2002	The apoptotic rate was increased, and Akt activity was decreased, suggesting that impaired nutrient and oxygen supply might contribute to diminished cell survival in dn EGFR tumors.	Oxygen	104-110	epidermal growth factor receptor	Mus musculus	169-173
25733617-13	2015	While the observed increase in the number of nif genes is strongly correlated with adaptation to utilize O2 in metabolism, the increase is not correlated with any of the known O2 protective mechanisms.	Oxygen	105-107	S100 calcium binding protein A9	Homo sapiens	45-48
26171830-0	2015	Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency.	Oxygen	0-6	sulfite oxidase	Homo sapiens	31-46
26171830-3	2015	In contrast, plant SO (PSO) lacks the haem domain and electrons shuttle from Moco to molecular oxygen.	Oxygen	95-101	sulfite oxidase	Homo sapiens	19-21
26171830-5	2015	In the present study, we generated mammalian haem-deficient and truncated SO variants and demonstrated their oxygen reactivity by hydrogen peroxide formation and oxygen-consumption studies.	Oxygen	109-115	sulfite oxidase	Homo sapiens	74-76
26171830-5	2015	In the present study, we generated mammalian haem-deficient and truncated SO variants and demonstrated their oxygen reactivity by hydrogen peroxide formation and oxygen-consumption studies.	Oxygen	162-168	sulfite oxidase	Homo sapiens	74-76
26171830-6	2015	We found that intramolecular electron transfer between Moco and haem showed an inverse correlation to SO oxygen reactivity.	Oxygen	105-111	sulfite oxidase	Homo sapiens	102-104
26171830-7	2015	Haem-deficient SO variants exhibited oxygen-dependent sulfite oxidation similar to PSO, which was confirmed further using haem-deficient human SO in a cell-based assay.	Oxygen	37-43	sulfite oxidase	Homo sapiens	15-17
26171830-9	2015	Therefore we evaluated the potential use of PEG attachment (PEGylation) as a modification method for future enzyme substitution therapies using oxygen-reactive SO variants, which might use blood-dissolved oxygen as the electron acceptor.	Oxygen	144-150	sulfite oxidase	Homo sapiens	160-162
25755167-1	2015	Gasification is a thermochemical pathway used to convert carbonaceous feedstock into syngas (CO and H2) in a deprived oxygen environment.	Oxygen	118-124	relaxin 2	Homo sapiens	93-102
26171830-9	2015	Therefore we evaluated the potential use of PEG attachment (PEGylation) as a modification method for future enzyme substitution therapies using oxygen-reactive SO variants, which might use blood-dissolved oxygen as the electron acceptor.	Oxygen	205-211	sulfite oxidase	Homo sapiens	160-162
12003775-2	2002	Type II cell proliferation after lung injury from 85% oxygen is regulated, in part, by a fall in lung PTHrP.	Oxygen	54-60	parathyroid hormone-related protein	Oryctolagus cuniculus	102-107
26051600-4	2015	Selectivity for Pb(II) is markedly improved as compared to the oxygen analogue 1 which was also competitive for Ca(II) ion.	Oxygen	63-69	carbonic anhydrase 2	Homo sapiens	112-118
25885573-7	2015	Since observed tendencies are suggestive of a possible genetic adaptation to hypoxia of the Chilean Aymara, we discuss briefly preliminary evidence related to fetal oxygen transport, particularly polymorphisms in the promoters of the HBG1 and HBG2 genes that are modulators of HbF synthesis, obtained in this ethnic group.	Oxygen	165-171	hemoglobin subunit gamma 1	Homo sapiens	234-238
25885573-7	2015	Since observed tendencies are suggestive of a possible genetic adaptation to hypoxia of the Chilean Aymara, we discuss briefly preliminary evidence related to fetal oxygen transport, particularly polymorphisms in the promoters of the HBG1 and HBG2 genes that are modulators of HbF synthesis, obtained in this ethnic group.	Oxygen	165-171	hemoglobin subunit gamma 2	Homo sapiens	243-247
12039760-5	2002	Since the Arabian Sea has a strong oxygen minimum zone between 100 and 1,000 m, with minimum oxygen levels of &lt;1 microM, the abundance of crenarchaeotal membrane lipids at 500 m suggests that planktonic Crenarchaeota are probably facultative anaerobes.	Oxygen	35-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	18-21
25855294-4	2015	We find that SHMT2 activity limits that of pyruvate kinase (PKM2) and reduces oxygen consumption, eliciting a metabolic state that confers a profound survival advantage to cells in poorly vascularized tumour regions.	Oxygen	78-84	serine hydroxymethyltransferase 2	Homo sapiens	13-18
25663339-5	2015	Dissolved oxygen (DO) in the water reduced the 2,4-DNT degradation and the formation of 2,4-DAT.	Oxygen	10-16	solute carrier family 6 member 3	Homo sapiens	92-95
26170516-7	2015	NAC increased O2 saturation significantly between time points (F (1.92, 73.1)=4.6, P=0.014).	Oxygen	14-16	X-linked Kx blood group	Homo sapiens	0-3
12039760-5	2002	Since the Arabian Sea has a strong oxygen minimum zone between 100 and 1,000 m, with minimum oxygen levels of &lt;1 microM, the abundance of crenarchaeotal membrane lipids at 500 m suggests that planktonic Crenarchaeota are probably facultative anaerobes.	Oxygen	93-99	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	18-21
12042811-2	2002	Here we show that accumulation of alpha-synuclein in cultured human dopaminergic neurons results in apoptosis that requires endogenous dopamine production and is mediated by reactive oxygen species.	Oxygen	183-189	synuclein alpha	Homo sapiens	34-49
26079803-0	2015	Oxygen regulates proliferation of neural stem cells through Wnt/beta-catenin signalling.	Oxygen	0-6	catenin (cadherin associated protein), beta 1	Mus musculus	64-76
26121248-9	2015	In contrast, oxygen consumed by mitochondrial glycerol phosphate dehydrogenase (mGPdH) was 30% lower.	Oxygen	13-19	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	80-85
25925954-3	2015	Here we utilized Ca(2+) ions and sulfur in place of the nucleophilic oxygen in a 20-residue pseudo-substrate peptide (CP20) and ATP to produce a close mimic of the Michaelis complex.	Oxygen	69-75	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	118-122
25926972-1	2015	BACKGROUND: This study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-inducible factor 1alpha.	Oxygen	74-80	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	207-238
25926972-9	2015	Finally, hyperbaric oxygen inhibited the acute distal colitis-induced up-regulation of hypoxia-inducible factor 1alpha.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	87-118
25873470-3	2015	Using whole-exome sequencing, we report the high association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with HAPH, mean pulmonary artery pressure &gt;50 mm Hg in two independent herds.	Oxygen	107-113	endothelial PAS domain protein 1	Bos taurus	67-72
25873470-3	2015	Using whole-exome sequencing, we report the high association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with HAPH, mean pulmonary artery pressure &gt;50 mm Hg in two independent herds.	Oxygen	107-113	endothelial PAS domain protein 1	Bos taurus	136-141
12022880-4	2002	Ni-ARD reacts with acireductone and dioxygen to produce methylthiopropionate, CO, and formate and does not lie on the methionine recycle pathway.	Oxygen	36-44	acireductone dioxygenase 1	Homo sapiens	0-6
25585871-5	2015	Under optimized 2.0 V of applied potential, 38 C of temperature, and 500 mL min(-1) of oxygen flow, over 90% of phenol, 60% of TOC and 20% of salinity were removed during 300 min of electrolysis time.	Oxygen	87-93	rhomboid 5 homolog 2	Homo sapiens	127-130
25639689-4	2015	In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (beta = 0.547; P = .003), anaerobic threshold (beta = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (beta = -10.15; P = .005), but not Patient Health Questionnaire scores (beta = -0.099; P = .586).	Oxygen	84-90	brain derived neurotrophic factor	Homo sapiens	32-36
25855513-1	2015	The objective of this study was to investigate how physiological, pharmacological, and pathological conditions that alter sodium reabsorption (TNa) in the proximal tubule affect oxygen consumption (QO2 ) and Na(+) transport efficiency (TNa/QO2 ).	Oxygen	178-184	C-type lectin domain family 3, member B	Rattus norvegicus	143-146
26039450-6	2015	Conversely, knockdown of ACL in myotubes not only reduces mitochondrial complex I, IV, and V activity but also blocks IGF1-induced increases in oxygen consumption.	Oxygen	144-150	ATP citrate lyase	Homo sapiens	25-28
25929654-6	2015	Cox6b1-3T3 cells showed increased oxygen consumption rates, Cox activity, and intracellular ATP concentrations, indicating enhanced mitochondrial respiration, compared with Con-3T3 cells.	Oxygen	34-40	cytochrome c oxidase subunit 4I1	Mus musculus	0-3
12027903-11	2002	IR difference spectra of the photooxidation reaction using the caged oxygen compound, and of the photoreduction reaction using the caged electron donor FMN, have inverted shapes.	Oxygen	69-75	formin 1	Homo sapiens	152-155
25913075-9	2015	In conclusion, a constitutively higher level of VEGF expression associated with retinal development protects GTPCH-deficient neonates from oxygen-induced vascular damage.	Oxygen	139-145	vascular endothelial growth factor A	Mus musculus	48-52
25730601-0	2015	Spin-orbit-torque engineering via oxygen manipulation.	Oxygen	34-40	spindlin 1	Homo sapiens	0-4
25730601-5	2015	We thus introduce a way to engineer spin-orbit torques via oxygen manipulation.	Oxygen	59-65	spindlin 1	Homo sapiens	36-40
11931958-6	2002	As the metal bound phosphonate groups are relatively bulky (six oxygens) and their negative charge above pH 4 is high (four per ligand) the equimolar species is a dominant complex at physiological pH.	Oxygen	64-71	prolyl 4-hydroxylase, transmembrane	Homo sapiens	105-109
25807530-7	2015	In these cells we show that a decrease in oxygen consumption rates (OCR) and electron transport chain (ETC) activity can be rescued by overexpression of wild type NARS2.	Oxygen	42-48	asparaginyl-tRNA synthetase 2, mitochondrial	Homo sapiens	163-168
26064225-0	2015	Temporal and spatial changes in VEGF, alphaA- and alphaB-crystallin expression in a mouse model of oxygen-induced retinopathy.	Oxygen	99-105	vascular endothelial growth factor A	Mus musculus	32-36
25809665-5	2015	In the presence of O2, the alpha subunits are hydroxylated by specific prolyl-4-hydroxylase domain proteins (PHD1, PHD2, and PHD3) and an asparaginyl hydroxylase (factor inhibiting HIF-1, FIH-1).	Oxygen	19-21	egl-9 family hypoxia inducible factor 3	Homo sapiens	125-129
25728686-3	2015	Recently, it has been shown that Arabidopsis cry1 activation by blue light also results in direct enzymatic conversion of molecular oxygen (O2 ) to reactive oxygen species (ROS) and hydrogen peroxide (H2 O2 ) in vitro.	Oxygen	132-138	cryptochrome 1	Arabidopsis thaliana	45-49
25728686-3	2015	Recently, it has been shown that Arabidopsis cry1 activation by blue light also results in direct enzymatic conversion of molecular oxygen (O2 ) to reactive oxygen species (ROS) and hydrogen peroxide (H2 O2 ) in vitro.	Oxygen	140-142	cryptochrome 1	Arabidopsis thaliana	45-49
26064225-18	2015	CONCLUSION: Using our mouse model of oxygen-induced retinopathy, we showed that the expression patterns of VEGF, alphaA- and alphaB-crystallins during retinal neovascularization in both spatially and temporally manners, providing significant insights into the molecular mechanisms of retinopathy and the associated neovascularization.	Oxygen	37-43	vascular endothelial growth factor A	Mus musculus	107-111
18968594-7	2002	Oxygen, trichloroacetic acid (TCA) and nitrite were catalytically reduced by Mb-PAM film electrodes with significant lowering of overpotential.	Oxygen	0-6	myoglobin	Homo sapiens	77-79
25889814-13	2015	In the extreme hypoxic conditions (0.2% oxygen), the overexpression of CCAAT enhancer-binding proteins (C/EBPs), especially C/EBPdelta, and HIF-1A upregulated the promoter activities of adipocyte-specific genes such as leptin, CFD, HIG2, LPL, PGAR.	Oxygen	40-46	CCAAT enhancer binding protein delta	Homo sapiens	124-134
25589425-5	2015	METHODS AND RESULTS: We found CNPY2 in a screen for genes induced by low oxygen in human smooth muscle cells (SMCs).	Oxygen	73-79	canopy FGF signaling regulator 2	Homo sapiens	30-35
25981588-4	2015	DMOG is known to inhibit oxygen-dependent degradation of hypoxia inducible factor-1 alpha (HIF-1alpha), which can lead to up-regulation of angiogenesis markers, favoring wound repair.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-89
25981588-4	2015	DMOG is known to inhibit oxygen-dependent degradation of hypoxia inducible factor-1 alpha (HIF-1alpha), which can lead to up-regulation of angiogenesis markers, favoring wound repair.	Oxygen	25-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	91-101
25820907-7	2015	Lactate dehydrogenase release and crystal violet staining revealed that IL-27 or IL-6 significantly attenuated severe hypoxia (SH, 2 % O2)-induced cell damage in H9c2 cardiomyoblasts and primary rat neonatal cardiomyocytes.	Oxygen	135-137	interleukin 27	Mus musculus	72-77
25733617-2	2015	Phylogenetic evidence indicates that oxygen (O2)-sensitive Nif emerged in an anaerobic archaeon and later diversified into an aerobic bacterium.	Oxygen	37-43	S100 calcium binding protein A9	Homo sapiens	59-62
25733617-2	2015	Phylogenetic evidence indicates that oxygen (O2)-sensitive Nif emerged in an anaerobic archaeon and later diversified into an aerobic bacterium.	Oxygen	45-47	S100 calcium binding protein A9	Homo sapiens	59-62
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	101-103	S100 calcium binding protein A9	Homo sapiens	76-79
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	101-103	S100 calcium binding protein A9	Homo sapiens	151-154
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	160-162	S100 calcium binding protein A9	Homo sapiens	76-79
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	160-162	S100 calcium binding protein A9	Homo sapiens	151-154
25578537-10	2015	High Glut1 activity was observed in the oocytes / embryos at 5% O2, indicative of high glucose uptake correlating with high expression of glycolytic genes.	Oxygen	64-66	solute carrier family 2 member 1	Homo sapiens	5-10
25348279-11	2015	Treatment with the VEGFR inhibitor axitinib or the VEGFR-3 specific inhibitor SAR131675 impaired lymphangiogenesis in the lung and improved oxygen saturation in the aspiration model.	Oxygen	140-146	kinase insert domain receptor	Homo sapiens	19-24
25348279-11	2015	Treatment with the VEGFR inhibitor axitinib or the VEGFR-3 specific inhibitor SAR131675 impaired lymphangiogenesis in the lung and improved oxygen saturation in the aspiration model.	Oxygen	140-146	fms related receptor tyrosine kinase 4	Homo sapiens	51-58
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	160-162	S100 calcium binding protein A9	Homo sapiens	76-79
25733617-3	2015	Aerobic bacteria that fix N2 have adapted a number of strategies to protect Nif from inactivation by O2, including spatial and temporal segregation of Nif from O2 and respiratory consumption of O2.	Oxygen	160-162	S100 calcium binding protein A9	Homo sapiens	151-154
25409745-5	2015	After airway injury using naphthalene, mice depleted of CCSP(+) BMC had more inflammatory cells in lung and decreased levels of oxygen in arterial blood.	Oxygen	128-134	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	56-60
11916399-4	2002	A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation.	Oxygen	183-191	complement C5	Homo sapiens	114-117
25409745-7	2015	After naphthalene injury, administration of CCSP reproduced the beneficial effect of CCSP(+) BMC by improving recovery of airway epithelium, reducing lung inflammation and increasing oxygen in arterial blood from mice depleted of CCSP(+) BMC.	Oxygen	183-189	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	44-48
25539718-0	2015	The expression of epidermal growth factor-like domain 7 regulated by oxygen tension via hypoxia inducible factor (HIF)-1alpha activity.	Oxygen	69-75	EGF like domain multiple 7	Homo sapiens	18-55
25462805-10	2015	With high yield Mb extraction and fast generation of an oxygen dissociation curve, it was possible to consistently determine Mb P50 under physiologically relevant conditions for endothermic vertebrates.	Oxygen	56-62	secernin 1	Bos taurus	128-131
25733617-6	2015	While the observed increase in the number of nif genes and their phylogenetic distribution are strongly correlated with adaptation to utilize O2 in metabolism, the increase is not correlated with any of the known O2 protection mechanisms.	Oxygen	142-144	S100 calcium binding protein A9	Homo sapiens	45-48
25587170-2	2015	We hypothesized that body position changes and oxygen desaturations may be associated with patient removal of the CPAP device.	Oxygen	47-53	centromere protein J	Homo sapiens	114-118
25587170-7	2015	At the same time, oxygen desaturations were significantly more frequent within 15 min before CPAP removal than during other periods when CPAP was used.	Oxygen	18-24	centromere protein J	Homo sapiens	93-97
12007789-0	2002	The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.	Oxygen	4-10	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
25587170-11	2015	CONCLUSIONS: Our findings are the first to indicate associations among CPAP removal, body position changes, and oxygen desaturations during sleep in poor CPAP adherers.	Oxygen	112-118	centromere protein J	Homo sapiens	71-75
25587170-11	2015	CONCLUSIONS: Our findings are the first to indicate associations among CPAP removal, body position changes, and oxygen desaturations during sleep in poor CPAP adherers.	Oxygen	112-118	centromere protein J	Homo sapiens	154-158
25658518-1	2015	Remarkable hydrogen evolution reaction (HER) or superior oxygen evolution reaction (OER) catalyst has been applied in water splitting, however, utilizing a bifunctional catalyst for simultaneously generating H2 and O2 is still a challenging issue, which is crucial for improving the overall efficiency of water electrolysis.	Oxygen	57-63	relaxin 2	Homo sapiens	208-217
25666609-9	2015	In its ferrous deoxy form, GLB-33 GD is capable of reversibly binding O2 with a very high affinity and of reducing nitrite to nitric oxide faster than other globins.	Oxygen	70-72	GLoBin related	Caenorhabditis elegans	27-33
25683712-3	2015	HIGD1A is induced in these HIF-deficient extreme environments and interacts with the mitochondrial electron transport chain to repress oxygen consumption, enhance AMPK activity, and lower cellular ROS levels.	Oxygen	135-141	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	0-6
12032628-2	2002	Because reduced oxygen availability is a major inducer of angiogenesis, we hypothesized that low cellular oxygen tension could regulate leptin expression in adipose cells.	Oxygen	16-22	leptin	Homo sapiens	136-142
25689462-1	2015	Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).	Oxygen	74-80	CREB binding protein	Mus musculus	176-196
25689462-1	2015	Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).	Oxygen	74-80	CREB binding protein	Mus musculus	198-201
25666609-10	2015	Collectively, these properties suggest that the globin domain of GLB-33 may serve as a highly sensitive oxygen sensor and/or as a nitrite reductase.	Oxygen	104-110	GLoBin related	Caenorhabditis elegans	65-71
25792458-3	2015	This study demonstrates that hypoxia, a common element of solid tumors harboring low oxygen levels, regulates expression of a specific variant of the scaffold protein AKAP12 (A-kinase anchor protein 12), AKAP12v2, in metastatic melanoma.	Oxygen	85-91	A-kinase anchoring protein 12	Homo sapiens	167-173
25792458-3	2015	This study demonstrates that hypoxia, a common element of solid tumors harboring low oxygen levels, regulates expression of a specific variant of the scaffold protein AKAP12 (A-kinase anchor protein 12), AKAP12v2, in metastatic melanoma.	Oxygen	85-91	A-kinase anchoring protein 12	Homo sapiens	175-201
25727410-0	2015	NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions.	Oxygen	124-130	catenin, beta like 1	Rattus norvegicus	0-3
25450972-5	2015	This resulted in impaired oxygen consumption in cultured Pex5(-/-) hepatocytes.	Oxygen	26-32	peroxisomal biogenesis factor 5	Mus musculus	57-61
12032628-2	2002	Because reduced oxygen availability is a major inducer of angiogenesis, we hypothesized that low cellular oxygen tension could regulate leptin expression in adipose cells.	Oxygen	106-112	leptin	Homo sapiens	136-142
25973000-0	2015	Hyperbaric oxygen intervention reduces secondary spinal cord injury in rats via regulation of HMGB1/TLR4/NF-kappaB signaling pathway.	Oxygen	11-17	high mobility group box 1	Rattus norvegicus	94-99
25973000-1	2015	BACKGROUND: To investigate whether hyperbaric oxygen (HBO) intervention affects the expressions of inflammatory cytokines, HMGB1/TLR4/NF-kappaB, and arrests secondary spinal cord injury (SCI).	Oxygen	46-52	high mobility group box 1	Rattus norvegicus	123-128
11916512-0	2002	Mathematical modeling of myoglobin facilitated transport of oxygen in devices containing myoglobin-expressing cells.	Oxygen	60-66	myoglobin	Homo sapiens	25-34
25973000-11	2015	CONCLUSIONS: Hyperbaric oxygen reduced the expressions of HMGB1, TLR4, and NF-kappaB and reduced secondary SCI as measured using BBB scores.	Oxygen	24-30	high mobility group box 1	Rattus norvegicus	58-63
24703425-9	2015	In luciferase assays and EMSA, the inducing effect of low oxygen could be assigned to HIF-1alpha, which binds to hypoxia responsive elements (HRE) in the OSTalpha and OSTbeta gene promoters.	Oxygen	58-64	solute carrier family 51 subunit alpha	Homo sapiens	154-162
11916512-0	2002	Mathematical modeling of myoglobin facilitated transport of oxygen in devices containing myoglobin-expressing cells.	Oxygen	60-66	myoglobin	Homo sapiens	89-98
11916512-6	2002	The mathematical analysis predicts that myoglobin facilitated oxygen transport has the potential of increasing the oxygen concentration at the centre of a cluster of cells (islet) with an effective radius of 100 microm by 50%.	Oxygen	62-68	myoglobin	Homo sapiens	40-49
25811377-3	2015	Moreover, ER function depends on proper disulfide bond formation--a partially oxygen-dependent process mediated by protein disulfide isomerase (PDI) and ER oxidoreductases.	Oxygen	78-84	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	115-142
25220215-4	2015	During successful no-go trials compared with oddball trials, methylphenidate induced an increase of blood oxygen level-dependent (BOLD) signal for carriers of the SLC6A3 9R allele but a decrease in 10/10 homozygotes in a thalamocortical network.	Oxygen	106-112	solute carrier family 6 member 3	Homo sapiens	163-169
11916512-6	2002	The mathematical analysis predicts that myoglobin facilitated oxygen transport has the potential of increasing the oxygen concentration at the centre of a cluster of cells (islet) with an effective radius of 100 microm by 50%.	Oxygen	115-121	myoglobin	Homo sapiens	40-49
25811377-3	2015	Moreover, ER function depends on proper disulfide bond formation--a partially oxygen-dependent process mediated by protein disulfide isomerase (PDI) and ER oxidoreductases.	Oxygen	78-84	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	144-147
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Oxygen	51-57	myoglobin	Homo sapiens	29-38
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Oxygen	51-57	myoglobin	Homo sapiens	143-152
25807077-5	2015	Three tumor cell lines (breast cancer MCF-7, colon cancer HCT116 and glioblastoma U87) showed a quick relocation of mTOR to mitochondria after irradiation with a single dose 5 Gy, which was companied with decreased lactate production, increased mitochondrial ATP generation and oxygen consumption.	Oxygen	278-284	small nucleolar RNA, C/D box 87	Homo sapiens	82-85
26257458-2	2015	Oxygen sensitive phosphors with glucose oxidase (GOx) can be used to determine glucose levels indirectly by monitoring oxygen consumption.	Oxygen	0-6	hydroxyacid oxidase 1	Homo sapiens	32-47
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Oxygen	212-218	myoglobin	Homo sapiens	29-38
26257458-2	2015	Oxygen sensitive phosphors with glucose oxidase (GOx) can be used to determine glucose levels indirectly by monitoring oxygen consumption.	Oxygen	0-6	hydroxyacid oxidase 1	Homo sapiens	49-52
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Oxygen	212-218	myoglobin	Homo sapiens	143-152
26257458-2	2015	Oxygen sensitive phosphors with glucose oxidase (GOx) can be used to determine glucose levels indirectly by monitoring oxygen consumption.	Oxygen	119-125	hydroxyacid oxidase 1	Homo sapiens	32-47
26257458-2	2015	Oxygen sensitive phosphors with glucose oxidase (GOx) can be used to determine glucose levels indirectly by monitoring oxygen consumption.	Oxygen	119-125	hydroxyacid oxidase 1	Homo sapiens	49-52
11902895-2	2002	Fe(OH)CrL(H(2)O)(6) and Al(OH)CrL(H(2)O)(6) are binuclear complexes, the metals ions being bridged via oxygen atoms.	Oxygen	103-109	interleukin 31 receptor A	Homo sapiens	6-9
25503547-5	2015	RESULTS: The transcription factor NURR1 (NR4A2) was identified as a downstream target induced by r-tPA during oxygen and glucose deprivation.	Oxygen	110-116	nuclear receptor subfamily 4 group A member 2	Homo sapiens	34-39
25503547-5	2015	RESULTS: The transcription factor NURR1 (NR4A2) was identified as a downstream target induced by r-tPA during oxygen and glucose deprivation.	Oxygen	110-116	nuclear receptor subfamily 4 group A member 2	Homo sapiens	41-46
25576627-6	2015	In gKO myocytes expressing Trpm2 or its mutants, Trpm2 but not E960D reduced the elevated mitochondrial superoxide (O2(.-)) levels in gKO myocytes.	Oxygen	116-118	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	49-54
25576627-7	2015	After hypoxia-reoxygenation (H/R), Trpm2 but not E906D or P1018L (inactivates Trpm2 current) lowered O2(.-) levels in gKO myocytes and only in the presence of extracellular Ca(2+), indicating sustained Ca(2+) entry is necessary for Trpm2-mediated preservation of mitochondrial function.	Oxygen	101-103	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	35-40
25539854-3	2015	We examined how Trx contributes to oxygen tolerance by creating transgenic mice with decreased levels of functional thioredoxin (dnTrx-Tg) using a dominant-negative approach.	Oxygen	35-41	thioredoxin 1	Mus musculus	16-19
25539854-9	2015	We also generated mice overexpressing Trx (Trx-Tg) and found they maintained lung redox balance during exposure to high oxygen and thus were resistant to hyperoxia-induced lung injury.	Oxygen	120-126	thioredoxin 1	Mus musculus	38-41
25539854-9	2015	We also generated mice overexpressing Trx (Trx-Tg) and found they maintained lung redox balance during exposure to high oxygen and thus were resistant to hyperoxia-induced lung injury.	Oxygen	120-126	thioredoxin 1	Mus musculus	43-49
25460197-9	2015	The idea is that sudden, disorderly, and excessive neuronal discharges activates NOX2 with O(2)(-) production, leading to lipid peroxidation.	Oxygen	91-98	cytochrome b-245 beta chain	Homo sapiens	81-85
25413349-1	2015	Factor inhibiting HIF (FIH, also known as HIF1AN) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs).	Oxygen	56-62	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	42-48
11902895-2	2002	Fe(OH)CrL(H(2)O)(6) and Al(OH)CrL(H(2)O)(6) are binuclear complexes, the metals ions being bridged via oxygen atoms.	Oxygen	103-109	interleukin 31 receptor A	Homo sapiens	30-33
11943204-1	2002	Using a method involving repeated oxygen uptake (MO(2)) determinations in skeletal muscle ex vivo, the addition of leptin was found to increase MO(2) in soleus muscles from lean mice.	Oxygen	34-40	leptin	Mus musculus	115-121
25542160-0	2015	Hyperbaric oxygen preconditioning attenuates hemorrhagic transformation through increasing PPARgamma in hyperglycemic MCAO rats.	Oxygen	11-17	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	91-100
25549925-8	2015	The molecular docking of luteolin in CBR1-NADPH complex showed that theflavonoid binds to the substrate-binding cleft, in which its 7-hydroxy group formed a H-bond with main-chain oxygen of Met234, in addition to H-bond interactions (of its 5-hydroxy and 4-carbonyl groups with catalytically important residues Tyr193 and/or Ser139) and a pi-stacking interaction (between its phenyl ring and Trp229).	Oxygen	180-186	carbonyl reductase 1	Homo sapiens	37-41
11877282-3	2002	We found that PAI-1 is tightly regulated in a narrow oxygen gradient.	Oxygen	53-59	serpin family E member 1	Homo sapiens	14-19
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Oxygen	332-338	sulfite oxidase	Homo sapiens	19-23
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Oxygen	332-338	sulfite oxidase	Homo sapiens	216-220
25161103-0	2015	Inhibition of metalloproteinase activity in FANCA is linked to altered oxygen metabolism.	Oxygen	71-77	FA complementation group A	Homo sapiens	44-49
11877282-4	2002	After incubation at oxygen concentrations of 1% to 2%, a 60-fold increase in PAI-1 messenger RNA levels was observed, whereas mild hypoxic conditions of more than 3.5% did not appear to induce transcription.	Oxygen	20-26	serpin family E member 1	Homo sapiens	77-82
25682875-7	2015	Repair of oxidative DNA damage and proliferation in 20% oxygen were both rescued in Cux1-/- MEFs by ectopic expression of CUX1 or of a recombinant Cut repeat protein that stimulates OGG1 but is devoid of transcription activation potential.	Oxygen	56-62	8-oxoguanine DNA-glycosylase 1	Mus musculus	182-186
11877282-5	2002	Moreover, increased levels of PAI-1 protein were observed after incubation at low oxygen tensions.	Oxygen	82-88	serpin family E member 1	Homo sapiens	30-35
12077976-5	2002	Greater oxygen feed in the furnaces of boilers and their use at the maximum capacities (loads) cause a decrease in B(a)P in the waste gases.	Oxygen	8-14	prohibitin 2	Homo sapiens	115-120
25634694-10	2015	However, HLA-G1 inhibited JAR and HTR-8/SVneo cells invasion induced by hepatocyte growth factor (HGF) under normal oxygen conditions.	Oxygen	116-122	major histocompatibility complex, class I, G	Homo sapiens	9-15
11939719-27	2002	adminstration, 2/ activation of leptin receptor in the pancreatic acini appears to be involved in the beneficial effects of leptin on acute pancreatitis, 3/ the protective effects of leptin involve sensory nerves, CGRP and increased generation of NO whereas melatonin-induced protection of the pancreas depends mainly on the antioxidant local effect of this indole, and scavenging of the radical oxygen species in the pancreatic tissue.	Oxygen	396-402	leptin receptor	Rattus norvegicus	32-47
25695603-5	2015	Hypoxia regulates Ets-1 at multiple levels according to the degree of beta-cell oxygen deprivation.	Oxygen	80-86	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	18-23
25280342-3	2015	As a certain amount of glucose was added into the detection cell, GOx rapidly catalyzed the oxidation of glucose, coupling with the local generation of H2O2 in the presence of dissolved O2.	Oxygen	154-156	hydroxyacid oxidase 1	Homo sapiens	66-69
11930234-7	2002	The results of this investigation suggest that the functional expression of HO-1 gene within VSMCs raises an alternative ability to protect the vascular cells against active oxygen injury.	Oxygen	174-180	heme oxygenase 1	Homo sapiens	76-80
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 2	Mus musculus	29-33
25675298-1	2015	Prolyl 4-hydroxylases (PHDs; PHD1, PHD2, and PHD3) are a component of cellular oxygen sensors that regulate the adaptive response depending on the oxygen concentration stabilized by hypoxia/stress-regulated genes transcription.	Oxygen	147-153	egl-9 family hypoxia-inducible factor 2	Mus musculus	29-33
12064871-6	2002	The bioactive phospholipids LPC, PAF and L-PAF may represent an oxygen-independent antimicrobial host defense system operative primarily against gram-positive bacteria.	Oxygen	64-70	PCNA clamp associated factor	Homo sapiens	33-36
25605899-6	2015	Using a mitochondria-targeted ATP biosensor, we showed that knockdown of endogenous Higd1a reduced oxygen consumption and subsequent mitochondrial ATP synthesis, leading to increased cell death in response to hypoxia; all of these phenotypes were rescued by exogenous Higd1a.	Oxygen	99-105	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	84-90
12064871-6	2002	The bioactive phospholipids LPC, PAF and L-PAF may represent an oxygen-independent antimicrobial host defense system operative primarily against gram-positive bacteria.	Oxygen	64-70	PCNA clamp associated factor	Homo sapiens	43-46
25520177-6	2015	In this study, we found that the expression levels of KDM6B mRNA and protein are modestly up-regulated under hypoxia (1% O2) or mimic hypoxia (desferrioxamine mesylate or CoCl2 treatment) (P&lt;0.05).	Oxygen	121-123	lysine demethylase 6B	Homo sapiens	54-59
11987242-2	2002	We previously found that CP patients may have increased serum erythropoietin (EPO) levels, ruled out linkage to both the EPO and EPO receptor (EPOR) gene loci, and hypothesized that the defect may lie in the oxygen homeostasis pathway.	Oxygen	208-214	erythropoietin receptor	Homo sapiens	143-147
25534037-7	2015	Our results showed that exposure of hASC to human BMP7 was associated with significant escalation of (1) UCP1 gene expression, a signature gene of brown adipocytes, (2) beige specific marker gene expression (i.e., CD137 and TMEM26), (3) glucose and fatty acid uptake, and (4) basal and cAMP-stimulated oxygen consumption rate compared to white adipocyte control.	Oxygen	302-308	bone morphogenetic protein 7	Homo sapiens	50-54
25499009-6	2015	RESULTS: Placental explants maintained at 3% O2 revealed decreased protein and transcript levels of VEGFR-2 with increased sFlt-1 and HIF1alpha.	Oxygen	45-47	kinase insert domain receptor	Homo sapiens	100-107
25522366-4	2015	For a biosensor with the glucose oxidase (GOx) enzyme in the presence of oxygen, the response of a metallic SWNT-GOx electrode was 2 times larger than that of a semiconducting SWNT-GOx electrode.	Oxygen	73-79	hydroxyacid oxidase 1	Homo sapiens	25-40
25522366-4	2015	For a biosensor with the glucose oxidase (GOx) enzyme in the presence of oxygen, the response of a metallic SWNT-GOx electrode was 2 times larger than that of a semiconducting SWNT-GOx electrode.	Oxygen	73-79	hydroxyacid oxidase 1	Homo sapiens	42-45
12230254-10	2002	On the contrary, and from mainly unknown reasons, these CA1 neurones are extremely sensitive to the reactive oxygen-triggered damage.	Oxygen	109-115	carbonic anhydrase 1	Rattus norvegicus	56-59
25522366-4	2015	For a biosensor with the glucose oxidase (GOx) enzyme in the presence of oxygen, the response of a metallic SWNT-GOx electrode was 2 times larger than that of a semiconducting SWNT-GOx electrode.	Oxygen	73-79	hydroxyacid oxidase 1	Homo sapiens	113-116
25522366-4	2015	For a biosensor with the glucose oxidase (GOx) enzyme in the presence of oxygen, the response of a metallic SWNT-GOx electrode was 2 times larger than that of a semiconducting SWNT-GOx electrode.	Oxygen	73-79	hydroxyacid oxidase 1	Homo sapiens	113-116
25522366-5	2015	In contrast, in the absence of oxygen, the response of the semiconducting SWNT-GOx electrode was retained, whereas that of the metallic SWNT-GOx electrode was significantly reduced.	Oxygen	31-37	hydroxyacid oxidase 1	Homo sapiens	79-82
11812905-5	2002	Activation of HIF-1 by hypoxia depends on rescue of its alpha-subunit from oxygen-dependent degradation in the proteasome, allowing it to form a heterodimer with HIF-1 beta.	Oxygen	75-81	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	162-172
25264201-0	2015	Hyperbaric oxygen preconditioning protects lung against hyperoxic acute lung injury in rats via heme oxygenase-1 induction.	Oxygen	11-17	heme oxygenase 1	Rattus norvegicus	96-112
12189042-9	2002	The role of intracellular myoglobin is generally accepted as that of a passive di-oxygen storage protein.	Oxygen	82-88	myoglobin	Homo sapiens	26-35
27182431-5	2015	In particular, we show that prolonged UV-irradiation of cytidine may lead to H-C1" hydrogen atom abstraction by the carbonyl oxygen atom of cytosine.	Oxygen	125-131	CYCS pseudogene 39	Homo sapiens	77-81
12420976-0	2002	Seasonal changes of nutrients and oxygen in the Bulgarian Black Sea coastal area.	Oxygen	34-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
25427906-6	2015	This Review will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1 as a result of CYP2E1-derived reactive oxygen intermediates promoting dissociation of the inhibitory thioredoxin from ASK-1.	Oxygen	265-271	thioredoxin 1	Mus musculus	327-338
11742085-4	2001	After 2 h of oxygen/glucose deprivation, BID cleavage was detected in neurons concurrent with caspase 8 activation but before caspase 3 cleavage.	Oxygen	13-19	caspase 8	Mus musculus	94-103
26401744-9	2015	The use of CPAP with oxygen supplementation is becoming highly popular.	Oxygen	21-27	centromere protein J	Homo sapiens	11-15
11709390-1	2001	Incubation of rat aortas with endotoxin and interferon-gamma for 24 h resulted in an aortic oxygen consumption that was substantially inhibited and strongly oxygen dependent (37% inhibition at 160 microM O(2) and 62% inhibition at 80 microM O(2) relative to untreated aortas).	Oxygen	92-98	interferon gamma	Rattus norvegicus	44-60
25385103-1	2015	Miravirsen is a beta-D-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide targeting the liver-specific microRNA-122 (miR-122).	Oxygen	23-26	microRNA 122	Homo sapiens	142-149
11709390-1	2001	Incubation of rat aortas with endotoxin and interferon-gamma for 24 h resulted in an aortic oxygen consumption that was substantially inhibited and strongly oxygen dependent (37% inhibition at 160 microM O(2) and 62% inhibition at 80 microM O(2) relative to untreated aortas).	Oxygen	157-163	interferon gamma	Rattus norvegicus	44-60
11709390-4	2001	Incubation of endothelial cells isolated from rat aortas with endotoxin and interferon-gamma for 24 h resulted in a steady-state NO concentration of approximately 0.5 microM and 90% inhibition of cellular oxygen consumption that was immediately reversed by an NO scavenger (oxyhemoglobin).	Oxygen	205-211	interferon gamma	Rattus norvegicus	76-92
11733717-0	2001	Hyperbaric oxygen treatment decreases post-ischemic neurotrophin-3 mRNA down-regulation in the rat hippocampus.	Oxygen	11-17	neurotrophin 3	Rattus norvegicus	52-66
25085943-1	2015	AIM: We hypothesised that short-term application of bi-level nasal continuous positive airway pressure CPAP (SiPAP) compared with conventional nasal CPAP (nCPAP) at the same mean airway pressure in infants with persistent oxygen need recovering from respiratory distress syndrome would improve CO2 removal with no change in oxygen requirement.	Oxygen	222-228	centromere protein J	Homo sapiens	103-107
25085943-1	2015	AIM: We hypothesised that short-term application of bi-level nasal continuous positive airway pressure CPAP (SiPAP) compared with conventional nasal CPAP (nCPAP) at the same mean airway pressure in infants with persistent oxygen need recovering from respiratory distress syndrome would improve CO2 removal with no change in oxygen requirement.	Oxygen	324-330	centromere protein J	Homo sapiens	103-107
25085943-8	2015	RESULTS: Twenty low-birthweight infants receiving 0.3+-0.04% supplemental oxygen on CPAP of 6 cm H2O were studied at an average of 33 days of age (+-23 days, SD).	Oxygen	74-80	centromere protein J	Homo sapiens	84-88
11733717-1	2001	The therapeutic effect of hyperbaric oxygen (HBO) on ischemic injury was investigated using in situ hybridization to detect the mRNA expression of neurotrophin-3 (NT-3), which is thought to play a crucial role in protecting against neuronal death induced by brain ischemia.	Oxygen	37-43	neurotrophin 3	Rattus norvegicus	147-161
11733717-1	2001	The therapeutic effect of hyperbaric oxygen (HBO) on ischemic injury was investigated using in situ hybridization to detect the mRNA expression of neurotrophin-3 (NT-3), which is thought to play a crucial role in protecting against neuronal death induced by brain ischemia.	Oxygen	37-43	neurotrophin 3	Rattus norvegicus	163-167
11606758-9	2001	However, O(2)(-) rather than H(2)O(2) is the primary ROI signal for pathogen induction of glutathione S-transferase, and the rates of production and dismutation of O(2)(-) generated during the oxidative burst play a crucial role in the modulation and integration of NO/H(2)O(2) signaling in the HR.	Oxygen	9-14	glutathione S-transferase	Glycine max	90-115
11606758-9	2001	However, O(2)(-) rather than H(2)O(2) is the primary ROI signal for pathogen induction of glutathione S-transferase, and the rates of production and dismutation of O(2)(-) generated during the oxidative burst play a crucial role in the modulation and integration of NO/H(2)O(2) signaling in the HR.	Oxygen	9-13	glutathione S-transferase	Glycine max	90-115
26649223-12	2015	Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.	Oxygen	47-53	troponin I3, cardiac type	Homo sapiens	6-10
25714978-4	2015	The interaction of leucine-rich repeat kinase and Fas- Associated protein with Death Domain has been implicated in the switching-on of the extrinsic apoptotic pathway via caspase-8 activation, while deficiency in PTEN induced putative kinase 1 has been shown to cause Ca2+ accumulation in mitochondria, increased generation of reactive oxygen species and intrinsic cell death.	Oxygen	336-342	PTEN induced kinase 1	Homo sapiens	213-243
25444857-1	2015	Cysteine dioxygenase (CDO) is a non-heme mononuclear iron enzyme that catalyzes the oxygen-dependent oxidation of L-cysteine (Cys) to produce L-cysteine sulfinic acid (CSA).	Oxygen	11-17	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
25381153-1	2015	Anti-VEGF therapy perturbs tumor metabolism, severely impairing oxygen, glucose, and ATP levels.	Oxygen	64-70	vascular endothelial growth factor A	Mus musculus	5-9
26020517-3	2015	The chemical oxygen demand (COD) results show that the final COD removal obtained for the BH effluent in the case of Cell 1 and Cell 2 is 800 and 150 mg O2L-1 after 5 and 6 h of electrolysis, respectively.	Oxygen	13-19	carboxyl ester lipase pseudogene	Homo sapiens	117-123
11791740-3	2001	During differentiation, expression of p22 and gp91 was at consistently low levels, even when the O2(-)-producing capacity was equivalent to that of normal neutrophils.	Oxygen	97-99	calcineurin like EF-hand protein 1	Homo sapiens	38-41
26020517-3	2015	The chemical oxygen demand (COD) results show that the final COD removal obtained for the BH effluent in the case of Cell 1 and Cell 2 is 800 and 150 mg O2L-1 after 5 and 6 h of electrolysis, respectively.	Oxygen	13-19	carboxyl ester lipase pseudogene	Homo sapiens	128-134
26307698-7	2015	The formation of other ions characteristic for these derivatives involves oxygen rearrangement giving rise to ions [C(n)F(2n+1)-C N(+)C(n)H(2n+1)] and [CnF(2n+1)-C N(+)-aryl].	Oxygen	74-80	NPHS1 adhesion molecule, nephrin	Homo sapiens	152-155
26291130-1	2015	We previously showed that incubation of chronic myeloid leukemia (CML) cells in very low oxygen selects a cell subset where the oncogenetic BCR/Abl protein is suppressed and which is thereby refractory to tyrosine kinase inhibitors used for CML therapy.	Oxygen	89-95	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	140-147
26291130-5	2015	Surprisingly, the drug also concentration-dependently enforced the maintenance of BCR/Abl signaling in low oxygen, an effect which was paralleled by the rescue of sensitivity of stem cell potential to IM.	Oxygen	107-113	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	82-89
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	162-164	vascular endothelial growth factor A	Mus musculus	96-100
11791740-5	2001	The results indicate that low expression of p22 and gp91 is sufficient to obtain normal O2- production, and that p47 might play an important regulatory role in the functional differentiation.	Oxygen	88-90	calcineurin like EF-hand protein 1	Homo sapiens	44-47
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	162-164	vascular endothelial growth factor A	Mus musculus	96-100
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	162-164	vascular endothelial growth factor A	Mus musculus	96-100
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	162-164	vascular endothelial growth factor A	Mus musculus	96-100
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	57-59	lipocalin 2	Homo sapiens	0-4
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	73-75	lipocalin 2	Homo sapiens	0-4
25341590-9	2015	NGAL and HIF-1alpha levels were also lower with Pressure-O2 and Pressure-O2/CO2 than with Flow-O2.	Oxygen	73-75	lipocalin 2	Homo sapiens	0-4
11693915-0	2001	Effect of overexpression of Saccharomyces cerevisiae Pad1p on the resistance to phenylacrylic acids and lignocellulose hydrolysates under aerobic and oxygen-limited conditions.	Oxygen	150-156	phenylacrylic acid decarboxylase PAD1	Saccharomyces cerevisiae S288C	53-58
25370861-6	2015	BDNF protein expression increased 24 to 48 hours after preconditioning, where inhibition of the BDNF Trk receptors abolished neuroprotection against oxygen and glucose deprivation (OGD) in vitro.	Oxygen	149-155	brain derived neurotrophic factor	Homo sapiens	0-4
25370861-6	2015	BDNF protein expression increased 24 to 48 hours after preconditioning, where inhibition of the BDNF Trk receptors abolished neuroprotection against oxygen and glucose deprivation (OGD) in vitro.	Oxygen	149-155	brain derived neurotrophic factor	Homo sapiens	96-100
25861159-6	2015	Deletion of AMPKalpha1 in the mixed glial cells of Abcd1-KO mice induced spontaneous mitochondrial dysfunction (lower oxygen consumption rate and ATP levels).	Oxygen	118-124	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	51-56
11693915-9	2001	This enabled faster growth for Pad1p-overexpressing transformants under both aerobic and oxygen-limited conditions.	Oxygen	89-95	phenylacrylic acid decarboxylase PAD1	Saccharomyces cerevisiae S288C	31-36
11435208-2	2001	We treated hyperoxia-exposed newborn rats with antibodies to the neutrophil chemokine cytokine-induced neutrophil chemoattractant-1 (CINC-1) during 95% O2 exposure to reduce adverse effects of hyperoxia-induced inflammation on lung development.	Oxygen	152-154	C-X-C motif chemokine ligand 1	Rattus norvegicus	133-139
25553116-3	2015	PDT is a photochemistry-based, clinically-used technique that consumes oxygen to generate cytotoxic species, thus causing changes in blood oxygen saturation (StO2).	Oxygen	71-77	16 steroid alpha-hydroxylase 2	Mus musculus	158-162
26328349-3	2015	XPS spectra analyses were conducted and the photocurrent was measured, which indicate the formation of Ti3+ and oxygen vacancies, and increased separation efficiency of photoactivated electrons and holes in electrochemically hydrogenated P25.	Oxygen	112-118	tubulin polymerization promoting protein	Homo sapiens	238-241
11435208-9	2001	Anti-CINC-1 preserved proliferating cell nuclear antigen expression in airway epithelium despite 95% O2 exposure.	Oxygen	101-103	C-X-C motif chemokine ligand 1	Rattus norvegicus	5-11
25878404-0	2015	Oxygen-Loaded Nanodroplets Effectively Abrogate Hypoxia Dysregulating Effects on Secretion of MMP-9 and TIMP-1 by Human Monocytes.	Oxygen	0-6	matrix metallopeptidase 9	Homo sapiens	94-99
25541690-7	2014	Furthermore, Warts downregulation in the trachea was similar to increased insulin receptor signaling during oxygen deprivation, which both rescued hypoxia-induced growth restriction, inhibition of tracheal molting, and developmental delay.	Oxygen	108-114	Insulin-like receptor	Drosophila melanogaster	74-90
25541690-8	2014	Insulin signaling and loss of Warts function increased tracheal growth and augmented tracheal plasticity under hypoxic conditions, enhancing oxygen delivery during periods of oxygen deprivation.	Oxygen	141-147	Insulin-like receptor	Drosophila melanogaster	0-7
25541690-8	2014	Insulin signaling and loss of Warts function increased tracheal growth and augmented tracheal plasticity under hypoxic conditions, enhancing oxygen delivery during periods of oxygen deprivation.	Oxygen	175-181	Insulin-like receptor	Drosophila melanogaster	0-7
25541690-9	2014	Our findings demonstrate a mechanism that coordinates oxygen availability with systemic growth in which hypoxia-induced reduction of insulin receptor signaling decreases plasticity of the larval trachea that is required for the maintenance of systemic growth during times of limiting oxygen availability.	Oxygen	54-60	Insulin-like receptor	Drosophila melanogaster	133-149
25541690-9	2014	Our findings demonstrate a mechanism that coordinates oxygen availability with systemic growth in which hypoxia-induced reduction of insulin receptor signaling decreases plasticity of the larval trachea that is required for the maintenance of systemic growth during times of limiting oxygen availability.	Oxygen	284-290	Insulin-like receptor	Drosophila melanogaster	133-149
26021677-7	2015	This was associated with increased airway alpha-smooth muscle actin expression at P21 after 40% oxygen exposure without a significant increase in MLC.	Oxygen	96-102	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	82-85
26021677-8	2015	Alveolar morphology via radial alveolar counts was comparably diminished by both 40 and 70% oxygen at both P8 and P21.	Oxygen	92-98	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	114-117
26179959-3	2015	In a prior study, it has also been shown that Arabidopsis cry1 activation by blue light results in direct enzymatic conversion of molecular oxygen (O2) to ROS (reactive oxygen species) in vivo leading to cell death in overexpressing lines.	Oxygen	140-146	cryptochrome 1	Arabidopsis thaliana	58-62
25531909-9	2014	The number of Pax7- and MyoD- or MyoD- and myogenin-positive nuclei per mm2 and the expression levels of these proteins were significantly higher in rats exposed to hyperbaric oxygen than in controls 5 days after injury.	Oxygen	176-182	paired box 7	Rattus norvegicus	14-18
11493595-2	2001	In the case of myoglobin (Mb), a prototype for structure-function relationship studies, the photosensitivity of the adduct of the reduced protein with CO, O2 and NO allows events related to the migration of the ligand through the matrix to be followed.	Oxygen	155-157	myoglobin	Homo sapiens	15-24
25336634-4	2014	SelH shRNA MRC-5 diploid fibroblasts under ambient O2 displayed a distinct profile of senescence including beta-galactosidase expression, autofluorescence, growth inhibition, and ATM pathway activation.	Oxygen	51-53	selenoprotein H	Homo sapiens	0-4
26179959-3	2015	In a prior study, it has also been shown that Arabidopsis cry1 activation by blue light results in direct enzymatic conversion of molecular oxygen (O2) to ROS (reactive oxygen species) in vivo leading to cell death in overexpressing lines.	Oxygen	148-150	cryptochrome 1	Arabidopsis thaliana	58-62
25553116-3	2015	PDT is a photochemistry-based, clinically-used technique that consumes oxygen to generate cytotoxic species, thus causing changes in blood oxygen saturation (StO2).	Oxygen	139-145	16 steroid alpha-hydroxylase 2	Mus musculus	158-162
25519840-12	2014	Under hypoxic conditions (3% oxygen) both ASCs and BM MSCs demonstrate increased RNA expression of H19 and Vascular endothelial growth factor A.	Oxygen	29-35	vascular endothelial growth factor A	Mus musculus	107-143
11525113-6	2001	The following factors were compared before and after home oxygen therapy: Subjective minimal capacity on exercise(metabolic equivalents: METs) before and 1 month after patients first became aware of dyspnea on effort using the specific activity scale(SAS); SaO2 at rest before and 1 month after; and frequency of admission during 1 year due to deterioration of heart failure.	Oxygen	58-64	tetraspanin 31	Homo sapiens	251-254
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Oxygen	161-168	glycophorin C (Gerbich blood group)	Homo sapiens	104-107
25428372-8	2014	The conformations of these binding pockets include direct binding through desolvated ion bridges in the GpC steps in B-DNA and A-RNA; direct binding to backbone oxygens; binding of Mg[(H2O)6](2+) to distant phosphates, resulting in acute bending of A-RNA; tight "ion traps" in Z-RNA between C-O2 and the C-O2" atoms in GpC steps; and others.	Oxygen	161-168	glycophorin C (Gerbich blood group)	Homo sapiens	319-322
25514679-6	2014	Immature SP-B, SP-A, SP-D and RAGE values were related to DLCO, peak oxygen consumption, ventilatory efficiency, and brain natriuretic peptide (BNP), whereas plasma mature SP-B was not.	Oxygen	69-75	long intergenic non-protein coding RNA 914	Homo sapiens	30-34
25541571-12	2014	Cholesterol analog spin-labels allowed discrimination of the cholesterol bilayer domain and acquisition of oxygen transport parameter profiles across this domain.	Oxygen	107-113	spindlin 1	Homo sapiens	19-23
25430436-10	2014	CONCLUSIONS: The present data indicate that TBP and B2M are appropriate housekeeping genes for normalization of transcript abundance measured by real-time RT-PCR in granulosa cells subjected to different plating densities, oxygen concentrations and FSH stimulation.	Oxygen	223-229	beta-2-microglobulin	Bos taurus	52-55
25505325-7	2014	Forward genetic screens indicate that GLB-5"s effects on O2 sensing require PDL-1, the C. elegans ortholog of mammalian PrBP/PDE6delta protein.	Oxygen	57-59	retinol binding protein 4	Homo sapiens	120-124
11525113-7	2001	RESULTS: After home oxygen therapy, SAS improved from 2.5 +/- 0.9 to 3.3 +/- 1.0 METs(p &lt; 0.0001), and SaO2 at rest improved from 92.8 +/- 2.5% to 96.3 +/- 1.6%(p &lt; 0.0001).	Oxygen	20-26	tetraspanin 31	Homo sapiens	36-39
25505325-9	2014	PDL-1 promotes localization of GCY-33 and GCY-35, atypical soluble guanylate cyclases that act as O2 sensors, to the dendritic endings of URX and BAG neurons, where they colocalize with GLB-5.	Oxygen	98-100	Guanylate cyclase;Soluble guanylate cyclase gcy-33	Caenorhabditis elegans	31-37
11566568-0	2001	Effect of oxygen concentration on the expression of glutathione S-transferase activity in periportal and perivenous rat hepatocyte cultures.	Oxygen	10-16	hematopoietic prostaglandin D synthase	Rattus norvegicus	52-77
25248834-0	2014	Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.	Oxygen	124-130	TIAM Rac1 associated GEF 1	Homo sapiens	13-18
25356789-4	2014	Significantly, the inhibitory effect of the probes on HIF-1alpha activity was consistent with that of the MDH2 enzyme assay, which was further confirmed by the effect on in vitro binding activity to recombinant human MDH2, oxygen consumption, ATP production, and AMP activated protein kinase (AMPK) activation.	Oxygen	223-229	malate dehydrogenase 2	Homo sapiens	106-110
11566568-12	2001	PV GST predominance was thus kept in particular when the highest oxygen concentration was used and made available to the cells through the gas-permeable membranes.	Oxygen	65-71	hematopoietic prostaglandin D synthase	Rattus norvegicus	3-6
25414194-5	2014	METHODS: Twist1 expression and localization were analyzed in a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	78-84	twist basic helix-loop-helix transcription factor 1	Mus musculus	9-15
25237066-4	2014	Directed mitochondrial accumulation of FerT in nonmalignant NIH3T3 cells increased their ETC complex I activity, ATP production, and survival, contingent upon stress conditions caused by nutrient and oxygen deprivation.	Oxygen	200-206	fer (fms/fps related) protein kinase	Mus musculus	39-43
25248834-0	2014	Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.	Oxygen	124-130	Rac family small GTPase 1	Homo sapiens	19-23
25120128-2	2014	Here, we explored the conceptually novel motivation to use supplemental oxygen as a treatment to inhibit the hypoxia/HIF-1alpha-CD39/CD73-driven accumulation of extracellular adenosine in the TME in order to weaken the tumor protection.	Oxygen	72-78	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	128-132
25266655-2	2014	We show here that hypoxia (low glucose and oxygen) triggers a rearrangement of the 14-3-3zeta interactome to favor an interaction with the core autophagy regulator Atg9A.	Oxygen	43-49	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	83-93
11510872-0	2001	Muscle oxygen desaturation is related to whole body VO2 during cross-country ski skating.	Oxygen	7-13	SKI proto-oncogene	Homo sapiens	77-80
24658911-6	2014	B7-H4 depletion suppressed oxygen consumption rate, ATP production, and mitochondrial membrane potential and mass and increased reactive oxygen species production.	Oxygen	27-33	V-set domain containing T cell activation inhibitor 1	Homo sapiens	0-5
25336519-5	2014	The contrasting effects of individual mutations in LCIB and LCIA compared with the effects of LCIB-LCIA double mutations on growth and inorganic carbon-dependent photosynthetic O2 evolution reveal distinct roles of LCIA and LCIB in the CCM.	Oxygen	177-179	uncharacterized protein	Chlamydomonas reinhardtii	51-55
25336519-5	2014	The contrasting effects of individual mutations in LCIB and LCIA compared with the effects of LCIB-LCIA double mutations on growth and inorganic carbon-dependent photosynthetic O2 evolution reveal distinct roles of LCIA and LCIB in the CCM.	Oxygen	177-179	uncharacterized protein	Chlamydomonas reinhardtii	94-98
25336519-5	2014	The contrasting effects of individual mutations in LCIB and LCIA compared with the effects of LCIB-LCIA double mutations on growth and inorganic carbon-dependent photosynthetic O2 evolution reveal distinct roles of LCIA and LCIB in the CCM.	Oxygen	177-179	uncharacterized protein	Chlamydomonas reinhardtii	94-98
25393282-7	2014	In addition, TBL2 knockdown can lead to impaired ATF4 induction under ER stress or poor nutrient conditions such as glucose and oxygen deprivation.	Oxygen	128-134	activating transcription factor 4	Homo sapiens	49-53
25365342-8	2014	Moreover, hypoxia increased TRPC6 expression at mRNA and protein levels in both cultured PVSMCs exposed to prolonged hypoxia (4% O2, 60 h) and distal PV isolated from CHPH rats.	Oxygen	129-131	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	28-33
25406289-2	2014	Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) antagonist/reverse agonist, GSK0660, inhibits VEGF-induced human retinal microvascular endothelial cell (HRMEC) proliferation, tubulogenesis, and oxygen-induced retinal vasculopathy in newborn rats.	Oxygen	217-223	peroxisome proliferator activated receptor delta	Homo sapiens	0-69
11438962-3	2001	(1)H-NMR studies of a mixture of model compound of CSP 1 and NBD-Ala suggest that the diastereomeric complex is composed of two hydrogen bonding sites at the amino proton and oxygen atom, and a pi-pi interaction by the benzofurazan structure (2,1,3-benzoxadiazole) of NBD-amino acid.	Oxygen	175-181	regulator of calcineurin 1	Homo sapiens	51-56
25372012-1	2014	There are three families of mononuclear molybdenum enzymes that catalyze oxygen atom transfer (OAT) reactions, named after a typical example from each family, viz., dimethyl sulfoxide reductase (DMSOR), sulfite oxidase (SO), and xanthine oxidase (XO).	Oxygen	73-79	sulfite oxidase	Homo sapiens	203-218
25372012-1	2014	There are three families of mononuclear molybdenum enzymes that catalyze oxygen atom transfer (OAT) reactions, named after a typical example from each family, viz., dimethyl sulfoxide reductase (DMSOR), sulfite oxidase (SO), and xanthine oxidase (XO).	Oxygen	73-79	sulfite oxidase	Homo sapiens	197-199
25289044-0	2014	Azurocidin-induced inhibition of oxygen metabolism in mitochondria is antagonized by heparin.	Oxygen	33-39	azurocidin 1	Homo sapiens	0-10
25289044-4	2014	However, the function of AZU in mitochondrial oxygen metabolism has yet to be reported.	Oxygen	46-52	azurocidin 1	Homo sapiens	25-28
11397907-6	2001	The level of p47(phox) subunit, an index of NADPH oxidase, the enzyme converting molecular oxygen to superoxide (O(.	Oxygen	91-97	pleckstrin	Homo sapiens	13-16
25289044-12	2014	In conclusion, the results indicated that AZU inhibited the oxygen metabolic function in mitochondria, and this function was effectively antagonized by heparin via the inhibition of AZU endocytosis by HUVECs.	Oxygen	60-66	azurocidin 1	Homo sapiens	42-45
25350109-0	2014	Obligatory role of intraluminal O2- in acute endothelin-1 and angiotensin II signaling to mediate endothelial dysfunction and MAPK activation in guinea-pig hearts.	Oxygen	32-34	endothelin-1	Cavia porcellus	45-57
25138176-5	2014	Locomotion assays showed that the defective O2-ON response of C20-PUFA (polyunsaturated fatty acid)-deficient, Delta-12 and Delta-6 fatty acid desaturase mutants (fat-2 and fat-3 respectively) can be restored by feeding the nematodes AA or EPA, but not ETYA (eicosatetraynoic acid), a non-metabolizable AA analogue.	Oxygen	44-46	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	163-168
25138176-5	2014	Locomotion assays showed that the defective O2-ON response of C20-PUFA (polyunsaturated fatty acid)-deficient, Delta-12 and Delta-6 fatty acid desaturase mutants (fat-2 and fat-3 respectively) can be restored by feeding the nematodes AA or EPA, but not ETYA (eicosatetraynoic acid), a non-metabolizable AA analogue.	Oxygen	44-46	Delta(6)-fatty-acid desaturase fat-3;FA_desaturase domain-containing protein	Caenorhabditis elegans	173-178
11294781-4	2001	Immunoblot analysis of embryos whose cell divisions are synchronized by inducible String (cdc25 homolog) demonstrated that cyclin B was degraded during low O2 conditions in interphase-arrested embryos but not in those arrested in metaphase.	Oxygen	156-158	Cyclin B	Drosophila melanogaster	123-131
25064694-4	2014	Here, we have found that a 24h-long exposure to slightly decreased ambient fractional concentration of oxygen (20% oxygen), which is an equivalent to oxygen tension at 350m above sea level, significantly increased levels of SUR2A in the heart despite that this drop of oxygen did not affect levels of O2, CO2 and hematocrit in the blood or myocardial levels of ATP, lactate and NAD/NADH/NAD(+).	Oxygen	103-109	sepia	Mus musculus	179-182
25093213-3	2014	At a platinum electrode in bis(trifluoromethylsulfonyl)imide (NTf2)-based ILs, methane is electro-oxidized to produce CO2 and water when an oxygen reduction process is included.	Oxygen	140-146	nuclear transport factor 2	Homo sapiens	62-66
11472112-9	2001	From the results, the conserved water molecule, corresponding to W206 in the E. coli DHFR complexes, that is H-bonded to both the OD2 oxygen atom of the carboxyl (Asp) side chain and O4 of the pterin/dihydropterin ring, appears critically important and may determine the protonation site for the enzyme-bound substrates.	Oxygen	134-140	Dihydrofolate reductase	Escherichia coli	85-89
24911618-5	2014	Thirty minutes of cycling at 64.5(3.2)% of maximum oxygen uptake was performed in Ex-Def from 0 to 0.5 h, which induced an energy deficit of 1469(256) kJ.	Oxygen	51-57	UTP25 small subunit processome component	Homo sapiens	85-88
26675066-5	2014	Low respiration with NADH-dependent substrates and increased respiration with glycerol-3-phosphate revealed complex I defects; changes in p 50 for oxygen and elevated uncoupling control ratio pointed to complex IV deficiency due to SURF1 or SCO2 mutation; high oligomycin sensitivity of state 3-ADP respiration, upregulated mitochondrial membrane potential and low content of complex V were found in lymphocytes with ATP synthase deficiency due to TMEM70 mutations.	Oxygen	147-153	activating signal cointegrator 1 complex subunit 1	Homo sapiens	138-142
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	59-63
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	matrix metallopeptidase 2	Mus musculus	65-70
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	156-160
24602608-5	2014	Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed.	Oxygen	11-17	matrix metallopeptidase 2	Mus musculus	162-167
25164807-7	2014	Silencing of Surf1 expression in Drosophila S2R(+) cells led to selective loss of COX activity associated with decreased oxygen consumption and respiratory reserve.	Oxygen	121-127	Surfeit 1	Drosophila melanogaster	13-18
25171301-7	2014	In the same suspensions (i.e., containing C-SWCNT, NADH, and O2), pBR322 DNA plasmid was cleaved, although  OH was not detected when using  OH scavenging molecular probes.	Oxygen	61-63	translocator protein	Homo sapiens	66-69
11254342-6	2001	Mb could act as an enzyme-like catalyst in DHP-PDDA films as demonstrated by catalytic reduction of trichloroacetic acid, nitrite, and oxygen with a decrease in the electrode potentials required.	Oxygen	135-141	myoglobin	Homo sapiens	0-2
25147336-6	2014	NDPKB-deficient (NDPKB(-/-)) mice were subjected to oxygen-induced retinopathy.	Oxygen	52-58	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	0-5
24712343-0	2014	Oxygen tension affects lubricin expression in chondrocytes.	Oxygen	0-6	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	Mus musculus	23-31
11334714-9	2001	Low oxygen tension (5% O(2)) decreased the intensity of CD44 immunofluorescence by 31%.	Oxygen	4-10	CD44 molecule (Indian blood group)	Rattus norvegicus	56-60
25099757-4	2014	As the capacity of donating electrons of X increases, the most negative electrostatic potentials outside the oxygen atom of O=PX3   (NCF)n (n = 0, 1, 2) become more negative, resulting in a stronger F   O halogen bond.	Oxygen	109-115	pannexin 3	Homo sapiens	126-129
25099757-5	2014	In the formation of a F   O halogen bond, along the sequence of X = F, Cl, Br, H, CH3 of the negative sites O=PX3, the electric field of the lone pair of oxygen becomes greater and causes a larger decrease in electron density outside the fluorine atom.	Oxygen	154-160	pannexin 3	Homo sapiens	110-113
25015576-7	2014	Haplotype analyses identified 3 haplotypes that included the minor alleles of rs1923534, rs721917, and rs3088308 that exhibited highly significant associations with decreased SP-D levels and decreased ORs for RD, oxygen supplementation, and respiratory support.	Oxygen	213-219	surfactant protein D	Homo sapiens	175-179
24712343-9	2014	HIF-1alpha gene silencing in ATDC5 cells attenuated the lubricin expression response to the oxygen tension.	Oxygen	92-98	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	Mus musculus	56-64
24712343-10	2014	These results corroborate with previous studies that the oxygen tension regulates lubricin gene expression and suggest that HIF-1alpha plays an important role in this regulation.	Oxygen	57-63	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	Mus musculus	82-90
11334714-9	2001	Low oxygen tension (5% O(2)) decreased the intensity of CD44 immunofluorescence by 31%.	Oxygen	23-27	CD44 molecule (Indian blood group)	Rattus norvegicus	56-60
24712343-11	2014	The normal distribution of lubricin in articular cartilage may be due to the hypoxic oxygen environment of cartilage as it is an avascular tissue.	Oxygen	85-91	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	Mus musculus	27-35
11401461-8	2001	This unexpected finding is due to the buffering effect of myoglobin, suggesting that in highly aerobic muscles short-term storage of oxygen is more important than the possibility of increasing transport through vasomotion.	Oxygen	133-139	myoglobin	Homo sapiens	58-67
25010400-0	2014	Cocaine- and amphetamine-regulated transcript facilitates the neurite outgrowth in cortical neurons after oxygen and glucose deprivation through PTN-dependent pathway.	Oxygen	106-112	CART prepropeptide	Mus musculus	0-45
25010400-1	2014	Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons.	Oxygen	174-180	CART prepropeptide	Mus musculus	0-45
25148305-5	2014	[Cr(BDT)(DEF)] DEF (3 DEF) is structurally flexible and reactive to O2 molecules because of the unsaturated Cr(2+) centers.	Oxygen	68-70	UTP25 small subunit processome component	Homo sapiens	9-12
25148305-5	2014	[Cr(BDT)(DEF)] DEF (3 DEF) is structurally flexible and reactive to O2 molecules because of the unsaturated Cr(2+) centers.	Oxygen	68-70	UTP25 small subunit processome component	Homo sapiens	15-18
25148305-5	2014	[Cr(BDT)(DEF)] DEF (3 DEF) is structurally flexible and reactive to O2 molecules because of the unsaturated Cr(2+) centers.	Oxygen	68-70	UTP25 small subunit processome component	Homo sapiens	15-18
25010400-1	2014	Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons.	Oxygen	174-180	CART prepropeptide	Mus musculus	47-51
11230110-9	2001	This stimulatory effect of activated EC supernatants on O(2)(-) release by neutrophils was abolished by anti-GM-CSF Ab or by PAF-receptor antagonist.	Oxygen	56-60	colony stimulating factor 2	Homo sapiens	109-115
25171328-3	2014	On the basis of the above observation, we conclude that the environmental adsorbates work by more than simply shifting the Fermi level of the CNTs; more importantly, these adsorbates cause a poor gate modulation efficiency of electron conduction due to the relatively large trap state density near the conduction band edge of the carbon nanotubes, for which we further propose quantitatively that the adsorbed oxygen-water redox couple is responsible.	Oxygen	410-416	TRAP	Homo sapiens	274-278
25200404-3	2014	Here, we observed the effect of hypoxia (2% O2) on CD9 expression and keratinocyte migration.	Oxygen	44-46	CD9 molecule	Homo sapiens	51-54
11248676-4	2001	Based on sequence and physiological data, SUT1 is a hypoxic gene negatively regulated when the cells are grown in the presence of oxygen.	Oxygen	130-136	Sut1p	Saccharomyces cerevisiae S288C	42-46
24992925-0	2014	Methylprednisolone inhibits the proliferation and affects the differentiation of rat spinal cord-derived neural progenitor cells cultured in low oxygen conditions by inhibiting HIF-1alpha and Hes1 in vitro.	Oxygen	145-151	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	177-187
24889205-3	2014	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription protein that regulates gene expression in the brain and other tissues in response to decreases in oxygen availability.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
24889205-3	2014	Hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription protein that regulates gene expression in the brain and other tissues in response to decreases in oxygen availability.	Oxygen	173-179	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
25229625-0	2014	Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury.	Oxygen	44-50	A-kinase anchoring protein 12	Homo sapiens	61-67
25229625-5	2014	AKAP12 is an effector of this mechanism, and its expression in meningeal cells is regulated by integrated upstream signals composed of TGF-beta1, RA and oxygen tension.	Oxygen	153-159	A-kinase anchoring protein 12	Homo sapiens	0-6
25229625-7	2014	Collectively, TGF-beta1, RA and oxygen tension can modulate the dynamic change in AKAP12 expression, causing prompt meningeal reconstruction after CNS injury by regulating the transition between the epithelial and mesenchymal states of meningeal cells.	Oxygen	32-38	A-kinase anchoring protein 12	Homo sapiens	82-88
25204429-1	2014	Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential process that provides nutrients and oxygen to the nascent tumor and thereby enhances tumor-cell survival and facilitates growth.	Oxygen	211-217	vascular endothelial growth factor A	Mus musculus	50-84
25204429-1	2014	Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential process that provides nutrients and oxygen to the nascent tumor and thereby enhances tumor-cell survival and facilitates growth.	Oxygen	211-217	vascular endothelial growth factor A	Mus musculus	86-90
25044775-4	2014	Herein, by combining chemical synthesis, NMR methods, and theoretical calculations, we show that it is possible to restore the anomeric effect for an acetal when replacing one of the oxygen atoms by a CF2 group.	Oxygen	183-189	ATPase H+ transporting accessory protein 1	Homo sapiens	201-204
11254668-6	2001	Disruption of the dADAR gene results in totally unedited sodium (Para), calcium (Dmca1A), and chloride (DrosGluCl-alpha) channels, a very prolonged recovery from anoxic stupor, a vulnerability to heat shock and increased O2 demands, and neuronal degeneration in aged flies.	Oxygen	221-223	Adenosine deaminase acting on RNA	Drosophila melanogaster	18-23
24888359-2	2014	Gp91phox contains all of the redox carriers necessary to reduce molecular oxygen to superoxide using NADPH.	Oxygen	74-80	cytochrome b-245 beta chain	Homo sapiens	0-8
11254668-7	2001	These data clearly demonstrate that, through the editing of ion channels as targets, dADAR, for which there are mammalian homologues, is essential for adaptation to altered environmental stresses such as O2 deprivation and for the prevention of premature neuronal degeneration.	Oxygen	204-206	Adenosine deaminase acting on RNA	Drosophila melanogaster	85-90
11240878-5	2001	Inspiratory to endtidal oxygen difference (FI-ETO2) was measured using a paramagnetic technique.	Oxygen	24-30	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	46-50
25145176-3	2014	Platinum-doped catalyst showed the best results in hydrogen generation, also producing methane, ethene and ethane, whereas the best oxygen production was exhibited by P25, followed by copper--and cobalt-containing photocatalysts.	Oxygen	132-138	tubulin polymerization promoting protein	Homo sapiens	167-170
24734982-6	2014	Low oxygen preconditioning primed mouse PSCs for their subsequent differentiation into mesodermal and endodermal lineages, as confirmed by increased gene expression of Eomes, Goosecoid, Brachyury, AFP, Sox17, FoxA2, and protein expression of Brachyury, Eomes, Sox17, FoxA2, relative to high oxygen cultures.	Oxygen	4-10	alpha fetoprotein	Mus musculus	197-200
11104757-4	2001	Functional parameters such as oxygen consumption rate under phosphorylating and nonphosphorylating conditions and proton permeability of the inner mitochondrial membrane were significantly reduced in fad2 mitochondrial membranes, while the thermal dependence of the respiration was enhanced.	Oxygen	30-36	fatty acid desaturase 2	Arabidopsis thaliana	200-204
25125975-10	2014	Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes.	Oxygen	194-200	C-C motif chemokine ligand 27	Homo sapiens	43-80
11171043-1	2001	Exposure of eukaryotic cells to a variety of reactive-oxygen-intermediate (ROI)-mediated sources of cellular injury, including heavy metals and UV radiation, induces the expression of heat-shock (HS) and stress-related genes among which is a 32-34 kDa protein identified as inducible haem oxygenase-1 (HO-1).	Oxygen	54-60	heme oxygenase 1	Homo sapiens	284-300
24865633-4	2014	Additionally, in vitro studies have shown that mitochondrial depolarization (IC50, 40 nM) and oxygen consumption (IC50, 99 nM) are strongly affected by decavanadate, which causes reduction of cytochrome b (complex III).	Oxygen	94-100	mitochondrially encoded cytochrome b	Homo sapiens	192-204
11171043-1	2001	Exposure of eukaryotic cells to a variety of reactive-oxygen-intermediate (ROI)-mediated sources of cellular injury, including heavy metals and UV radiation, induces the expression of heat-shock (HS) and stress-related genes among which is a 32-34 kDa protein identified as inducible haem oxygenase-1 (HO-1).	Oxygen	54-60	heme oxygenase 1	Homo sapiens	302-306
25199329-3	2014	Her Sp(O2) was 92-93% even after administration of 10 l x min(-1) oxygen through a reservoir-attached face mask.	Oxygen	66-72	immunoglobulin kappa variable 1D-39	Homo sapiens	4-9
11292898-11	2001	Oxygen delivery of terminal cardioplegia was almost four times higher in HS-B group (90.4+/-17.7 vs 18.7+/-1.1 mcl/ml), contrarily, HS-C group showed four times higher oxygen extraction ratio compared to HS-B group (0.78+/-0.06 vs 0.18+/-0.11), thus oxygen consumption during hot shot was maintained at the same level in both groups.	Oxygen	168-174	fucosyltransferase 1 (H blood group)	Homo sapiens	132-136
25002513-0	2014	Collective spin 1 singlet phase in high-pressure oxygen.	Oxygen	49-55	spindlin 1	Homo sapiens	11-17
11292898-11	2001	Oxygen delivery of terminal cardioplegia was almost four times higher in HS-B group (90.4+/-17.7 vs 18.7+/-1.1 mcl/ml), contrarily, HS-C group showed four times higher oxygen extraction ratio compared to HS-B group (0.78+/-0.06 vs 0.18+/-0.11), thus oxygen consumption during hot shot was maintained at the same level in both groups.	Oxygen	250-256	fucosyltransferase 1 (H blood group)	Homo sapiens	132-136
11426476-10	2001	There appeared to be no differences on all physiological measured parameters apart from partial pressure of oxygen during the arrest which was higher in the NDE group.	Oxygen	108-114	nudE neurodevelopment protein 1	Homo sapiens	157-160
25197344-1	2014	To determine whether Hyperbaric oxygen preconditioning (HBO-PC) promotes neovascularization by increasing Stromal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in transplanted skin flaps of rats.	Oxygen	32-38	C-X-C motif chemokine receptor 4	Rattus norvegicus	148-172
25197344-1	2014	To determine whether Hyperbaric oxygen preconditioning (HBO-PC) promotes neovascularization by increasing Stromal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in transplanted skin flaps of rats.	Oxygen	32-38	C-X-C motif chemokine receptor 4	Rattus norvegicus	174-179
24738713-2	2014	This study aimed to assess the effect of low-pressure continuous positive airway pressure (CPAP) with pressure support ventilation (PSV) during pre-oxygenation on partial oxygen pressure in arterial blood (PaO2 ) immediately after tracheal intubation (post-intubation PaO2).	Oxygen	148-154	centromere protein J	Homo sapiens	91-95
24842617-6	2014	Similarly, in the presence of ascorbic acid, HQ is transformed into 2-hydroxy-p-benzoquinone by the action of tyrosinase; however, in this case, ascorbic acid reduces met-tyrosinase to deoxy-tyrosinase, which after binding to oxygen, originates oxy-tyrosinase.	Oxygen	226-232	tyrosinase	Homo sapiens	110-120
11953028-0	2001	Low oxygen tension and autologous plasma enhance T-cell proliferation and CD49d expression density in serum-free media.	Oxygen	4-10	integrin subunit alpha 4	Homo sapiens	74-79
24710790-2	2014	When these slices were then transferred to a medium containing oxygen and glucose (reoxygenation, REO), S100B release rose to 344 % of its control value.	Oxygen	63-69	S100 calcium binding protein B	Rattus norvegicus	104-109
11106506-5	2000	Phenethylamine oxidation by MAO A can be described as the C-H bond cleavage step being rate limiting in catalysis and with oxygen reacting with the reduced enzyme-imine complex.	Oxygen	123-129	monoamine oxidase A	Homo sapiens	28-33
24831825-2	2014	The current density functional theory (DFT) results demonstrate the process of CO oxidation by lattice oxygen on the SnO2(110) surface and the recovery of the reduced surface by O2.	Oxygen	103-109	strawberry notch homolog 2	Homo sapiens	117-120
11193510-8	2000	beta 2 AR KO subjected to treadmill exercise showed significant hypertension, increased oxygen consumption, and ability of long distance running.	Oxygen	88-94	adrenergic receptor, beta 2	Mus musculus	0-9
24920629-5	2014	Ischemia induced either by embolic middle cerebral artery occlusion (MCAO) in vivo or by oxygen and glucose deprivation in brain slices caused calpain-dependent conversion of the Cdk5-activating cofactor p35 to p25.	Oxygen	89-95	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	204-207
24920629-5	2014	Ischemia induced either by embolic middle cerebral artery occlusion (MCAO) in vivo or by oxygen and glucose deprivation in brain slices caused calpain-dependent conversion of the Cdk5-activating cofactor p35 to p25.	Oxygen	89-95	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	211-214
11123679-4	2000	The targets for H-NS-mediated aerobic repression are the four oxygen-regulated promoters, designated P1, P2, P3 and P4.	Oxygen	62-68	H-NS	Escherichia coli	16-20
24430503-4	2014	Furthermore, single domains with either hcp or epsilon crystalline structure behave differently upon oxygen diffusion.	Oxygen	101-107	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	40-43
11109058-7	2000	A negative correlation was found between CCSP and inspiratory oxygen concentration, and a positive correlation between CCSP and both arterial pH and base excess during the first 2 postnatal weeks.	Oxygen	62-68	secretoglobin family 1A member 1	Homo sapiens	41-45
24700124-7	2014	Neonatal mice from a model of oxygen-induced retinopathy showed suppressed neovascular growth in the retina when endothelial PFKFB3 was genetically deleted or when the mice were treated with a PFKFB3 inhibitor.	Oxygen	30-36	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	125-131
24700124-7	2014	Neonatal mice from a model of oxygen-induced retinopathy showed suppressed neovascular growth in the retina when endothelial PFKFB3 was genetically deleted or when the mice were treated with a PFKFB3 inhibitor.	Oxygen	30-36	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	193-199
24477044-0	2014	Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury.	Oxygen	44-50	dynamin 1-like	Rattus norvegicus	0-4
11236633-7	2000	RESULTS: The expression of VEGF in PAEC was increased under hypoxia condition (1% O2) (P &lt; 0.01).	Oxygen	82-84	vascular endothelial growth factor A	Rattus norvegicus	27-31
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Oxygen	82-88	cyclin dependent kinase 1	Homo sapiens	176-201
25241977-0	2014	[The effect of semaphorin 3A in the process of apoptosis in oxygen induced retinopathy in rats].	Oxygen	60-66	semaphorin 3A	Rattus norvegicus	15-28
25241977-1	2014	OBJECTIVE: To observe the change of semaphorin 3A (SEMA3A) expression in the retina of oxygen induced retinopathy (OIR) in rats and to investigate its influence on retinal degeneration in OIR.	Oxygen	87-93	semaphorin 3A	Rattus norvegicus	36-49
25241977-1	2014	OBJECTIVE: To observe the change of semaphorin 3A (SEMA3A) expression in the retina of oxygen induced retinopathy (OIR) in rats and to investigate its influence on retinal degeneration in OIR.	Oxygen	87-93	semaphorin 3A	Rattus norvegicus	51-57
24700462-7	2014	The MetAP2 disulfide bond also exists in oxidized and reduced states in glioblastoma tumor cells, and stressing the cells by oxygen or glucose deprivation results in more oxidized enzyme.	Oxygen	125-131	methionyl aminopeptidase 2	Homo sapiens	4-10
24738702-6	2014	Trophoblast cells overexpressing STOX1 displayed an increased mitochondrial activity at 20% O2 and in hypoxia, despite reduction of the mitochondrial mass in the former.	Oxygen	92-94	storkhead box 1	Homo sapiens	33-38
24738702-9	2014	At low oxygen pressure, STOX1 overexpression switched the free radical balance from reactive oxygen species (ROS) to reactive nitrogen species (RNS) in the placenta as well as in a trophoblast cell line.	Oxygen	7-13	storkhead box 1	Homo sapiens	24-29
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Oxygen	82-88	cyclin dependent kinase 1	Homo sapiens	203-207
10921504-0	2000	Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.	Oxygen	34-40	PCNA clamp associated factor	Homo sapiens	58-84
24939847-9	2014	This novel post-translational modification highlights the nonequivalence of human Hb alpha, beta, and gamma subunits with respect to redox reactivity and may have direct implications to alpha/beta hemoglobinopathies and design of oxidatively stable Hb-based oxygen therapeutics.	Oxygen	258-264	keratin 90, pseudogene	Homo sapiens	82-90
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Oxygen	57-59	hemoglobin beta chain complex	Mus musculus	130-137
10921504-1	2000	Although it has been suggested that some biological activities of platelet-activating factor (PAF) are mediated by, at least in part, reactive oxygen intermediates (ROI), the precise mechanisms underlying the interaction between the two remains to be elucidated.	Oxygen	143-149	PCNA clamp associated factor	Homo sapiens	66-92
25033220-1	2014	Body cell mass (BCM) is the metabolically active cell mass involved in O2 consumption, CO2 production and energy expenditure.	Oxygen	71-73	TNF receptor superfamily member 17	Homo sapiens	16-19
24359187-5	2014	Hypoxia (1% O2 for 22 h) caused greater loss of viability and more marked activation of caspase 3/7 in the motor neuronal NSC-34 cell line stably transfected with the G93A mutant human SOD1 (G93A-NSC) than in the one with the wild-type SOD1 (WT-NSC) or in untransfected NSC-34.	Oxygen	12-14	caspase 3	Mus musculus	88-99
24080997-6	2014	BAS 90-30-90 refers to the vital signs: oxygen saturation, respiratory rate, and systolic blood pressure.	Oxygen	40-46	BAS	Homo sapiens	0-3
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Oxygen	139-145	aconitase 1	Mus musculus	0-32
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Oxygen	139-145	aconitase 1	Mus musculus	34-38
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Oxygen	139-145	iron responsive element binding protein 2	Mus musculus	43-47
24591572-2	2014	Here we show that hypoxia (&lt;5% O2), in addition to inhibiting the two-pore domain K(+) channels TASK-1/3 (TASK), indirectly activates an ~20 pS channel in isolated glomus cells.	Oxygen	34-36	potassium two pore domain channel subfamily K member 3	Rattus norvegicus	99-107
10921504-1	2000	Although it has been suggested that some biological activities of platelet-activating factor (PAF) are mediated by, at least in part, reactive oxygen intermediates (ROI), the precise mechanisms underlying the interaction between the two remains to be elucidated.	Oxygen	143-149	PCNA clamp associated factor	Homo sapiens	94-97
11018744-1	2000	Glutathione S-transferases (GSTs) are an important part of the cellular detoxification system and, perhaps, evolved to protect cells against reactive oxygen metabolites.	Oxygen	150-156	glutathione S-transferase, theta 1	Mus musculus	28-32
24328551-4	2014	Dimethyloxaloylglycine (DMOG) is a cell-permeable prolyl-4-hydroxylase inhibitor, which can activate the expression of HIF-1alpha in cells at normal oxygen tension.	Oxygen	149-155	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	119-129
25050546-2	2014	In this study we demonstrate that CNN3 levels are upregulated under low oxygen conditions in the trophoblast cell line BeWo.	Oxygen	72-78	calponin 3	Homo sapiens	34-38
25050546-7	2014	These results indicate that CNN3 promotes invasive processes by the stimulation of ERK1/2 and/or p38 under normoxic conditions in BeWo cells, but seems to have different functions at low oxygen levels.	Oxygen	187-193	calponin 3	Homo sapiens	28-32
25050546-10	2014	In summary, we identified CNN3 as a new pro-invasive protein in trophoblast cells that is induced under low oxygen conditions.	Oxygen	108-114	calponin 3	Homo sapiens	26-30
10960491-4	2000	Recently, we have demonstrated that leukocyte activation by L-selectin transmits several intracellular signaling cascades resulting in capping and cytoskeletal changes, the activation of kinases and neutral sphingomyelinase, the recruitment of adaptor proteins to the cell membrane, the activation of the small G-proteins Ras and Rac, and the release of oxygen.	Oxygen	354-360	selectin L	Homo sapiens	60-70
24867811-2	2014	Both laccase and tyrosinase are copper-containing phenoloxidases requiring readily available O2 without auxiliary cofactor for their catalytic transformation of numerous phenolic substrates.	Oxygen	93-95	tyrosinase	Homo sapiens	17-27
24245768-1	2014	AIM: Recently, TRPA1 channels, richly expressed in both peripheral and central neural systems, have been proposed as novel sensors of changes in oxygen concentration along the hypoxic-hyperoxic continuum.	Oxygen	145-151	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	15-20
11028541-11	2000	Conversely, HTS attenuated PAF priming of PMA-mediated O2- production.	Oxygen	55-57	PCNA clamp associated factor	Homo sapiens	27-30
24565757-5	2014	Decreasing BRCA1 content using a shRNA approach in cultured primary human myotubes resulted in decreased oxygen consumption by the mitochondria and increased reactive oxygen species production.	Oxygen	105-111	BRCA1 DNA repair associated	Homo sapiens	11-16
24758166-2	2014	In mammalian cells, the major pathway for de novo disulfide formation involves the enzyme Ero1alpha (endoplasmic reticulum oxidase 1alpha) which couples oxidation of thiols to the reduction of molecular oxygen to form hydrogen peroxide (H2O2).	Oxygen	203-209	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	90-99
24726658-7	2014	RESULTS: Lowering O2 concentration from 21% to the physiologically relevant 5% level substantially affected cell characteristics, with induction of stemness-related-transcription-factor and stimulation of cell proliferative capacity, with increased colony-forming unit fibroblasts (CFU-F) centers exerting OCT4A, NANOG and HIF-1alpha and HIF-2alpha immunoreactivity.	Oxygen	18-20	Nanog homeobox	Homo sapiens	313-318
10930551-4	2000	We found that cystatin C and HuC mRNA, the products of which are an inhibitor of cysteine proteases and an RNA binding protein, respectively, were up-regulated in neurons cultured in the high oxygen atmosphere.	Oxygen	192-198	cystatin C	Rattus norvegicus	14-24
24989661-3	2014	The expression of microRNA-21 in normal myocardial cells and cells treated with low oxygen exposure for 6 and 24 h were assessed by real-time fluorescent quantitative RT-PCR.	Oxygen	84-90	microRNA 21	Rattus norvegicus	18-29
24507647-10	2014	Retinal oxygen can induce over-expression of HIF-1alpha and VEGF.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	45-55
24668752-8	2014	Subjecting human umbilical vein endothelial cells (HUVECs) to low oxygen, mimicking a characteristic of neovessels, decreased the expression of the complement inhibitor Cd55.	Oxygen	66-72	CD55 molecule (Cromer blood group)	Homo sapiens	169-173
10930551-6	2000	Cystatin C protein levels were also increased in neurons cultured in the high oxygen atmosphere.	Oxygen	78-84	cystatin C	Rattus norvegicus	0-10
10930551-7	2000	In situ hybridization with an RNA probe for rat cystatin C and immunocytochemistry with anti-human cystatin C antibody showed that microtubule-associated protein 2 (MAP2)-positive neurons expressed cystatin C mRNA and protein, respectively, in the high oxygen atmosphere.	Oxygen	253-259	microtubule-associated protein 2	Rattus norvegicus	131-163
10930551-7	2000	In situ hybridization with an RNA probe for rat cystatin C and immunocytochemistry with anti-human cystatin C antibody showed that microtubule-associated protein 2 (MAP2)-positive neurons expressed cystatin C mRNA and protein, respectively, in the high oxygen atmosphere.	Oxygen	253-259	microtubule-associated protein 2	Rattus norvegicus	165-169
24841106-11	2014	CONCLUSIONS: No definitive indication of independent immunological activity resulting from apneas and hypopneas was found in final models adjusted for other factors associated with inflammation, whereas average oxygen saturation for MRP-8/14 and ODI for CRP remained statistically significant predictors.	Oxygen	211-217	ATP binding cassette subfamily C member 11	Homo sapiens	233-238
24374061-5	2014	Similar changes are seen in PINK1 knockdown cells, in which potential, oxygen consumption and mitochondrial mass are all decreased.	Oxygen	71-77	PTEN induced kinase 1	Homo sapiens	28-33
10903143-5	2000	According to the crystal structure of HSA, the residues Arg-410 and Tyr-411 protrude into the centre of site II (in subdomain 3A), and the binding results showed that the guanidino moiety of Arg-410, the phenolic oxygen and the aromatic ring of Tyr-411 are important for ketoprofen binding.	Oxygen	213-219	CD24 molecule	Rattus norvegicus	38-41
24321316-7	2014	Depletion of membrane-associated RacGAPs had a selective effect: a decrease in ARHGAP1 or ARHGAP25 level increased O2(-) production but a depletion of ARHGAP35 had no effect.	Oxygen	115-117	Rho GTPase activating protein 1	Homo sapiens	79-86
24321316-7	2014	Depletion of membrane-associated RacGAPs had a selective effect: a decrease in ARHGAP1 or ARHGAP25 level increased O2(-) production but a depletion of ARHGAP35 had no effect.	Oxygen	115-117	Rho GTPase activating protein 25	Homo sapiens	90-98
24321316-9	2014	Thus, in neutrophils multiple RacGAPs are involved in the control of O2(-) production by Nox2, allowing selective regulation via different signaling pathways.	Oxygen	69-71	cytochrome b-245 beta chain	Homo sapiens	89-93
24419175-10	2014	It is shown that 1 resides in the interior of P1 and P2, and is thus in a location where undesirable quenching pathways of the photo-excited state of 1 limit the oxygen production yields for both P1 and P2.	Oxygen	162-168	crystallin gamma F, pseudogene	Homo sapiens	46-55
24419175-10	2014	It is shown that 1 resides in the interior of P1 and P2, and is thus in a location where undesirable quenching pathways of the photo-excited state of 1 limit the oxygen production yields for both P1 and P2.	Oxygen	162-168	crystallin gamma F, pseudogene	Homo sapiens	196-205
24555826-9	2014	Three genes significantly impact survival rates in low oxygen: cic, an ortholog of human CIC, Hsl, an ortholog of human LIPE, and Paf-AHalpha, an ortholog of human PAFAH1B3.	Oxygen	55-61	lipase E, hormone sensitive type	Homo sapiens	94-97
24555826-9	2014	Three genes significantly impact survival rates in low oxygen: cic, an ortholog of human CIC, Hsl, an ortholog of human LIPE, and Paf-AHalpha, an ortholog of human PAFAH1B3.	Oxygen	55-61	lipase E, hormone sensitive type	Homo sapiens	120-124
24491761-3	2014	The GOx assembled on the nanoprobe can catalyze glucose to generate H2O2 in the presence of O2 while the ECL reaction occurred in the luminol ECL biosensor.	Oxygen	70-72	hydroxyacid oxidase 1	Homo sapiens	4-7
24360989-3	2014	Exposing the BMCs to 3%, 5%, or 10% O2 in the presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) generated tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells, consistent with OCs.	Oxygen	36-38	TNF superfamily member 11	Homo sapiens	58-96
24360989-3	2014	Exposing the BMCs to 3%, 5%, or 10% O2 in the presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) generated tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells, consistent with OCs.	Oxygen	36-38	TNF superfamily member 11	Homo sapiens	98-103
24574965-4	2014	Exposure to chronic hypoxia (10% oxygen for 6-72 h) stimulated the activation of the Wnt/beta-catenin signaling pathway.	Oxygen	33-39	catenin (cadherin associated protein), beta 1	Mus musculus	89-101
23469813-1	2014	Methemoglobin concentration is an important pathophysiological biomarker, reflecting the oxygen-carrying and oxygen-releasing capabilities of hemoglobin (Hb).	Oxygen	89-95	hemoglobin subunit gamma 2	Homo sapiens	0-13
23469813-1	2014	Methemoglobin concentration is an important pathophysiological biomarker, reflecting the oxygen-carrying and oxygen-releasing capabilities of hemoglobin (Hb).	Oxygen	109-115	hemoglobin subunit gamma 2	Homo sapiens	0-13
24323731-1	2014	Hypoxia inducible factor (HIF)-1alpha is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia.	Oxygen	98-104	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-37
27774462-9	2014	Bcr/Abl protein suppression turned out to be actually determined when glucose shortage complicated the effects of low oxygen, indicating that ischemia-like conditions are the driving force of leukemia stem cell refractoriness to imatinib mesylate.	Oxygen	118-124	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
24418892-8	2014	Correspondingly, we observed increased oxygen consumption in PTBP1-knockdown breast cancer cells.	Oxygen	39-45	polypyrimidine tract binding protein 1	Homo sapiens	61-66
24410212-4	2014	High-level ab initio calculations which reproduce the experimentally determined values well indicate that the in-plane C-H bond in the methyl moiety is trans to the C-O bond, and other two protons are directed to the terminal oxygen atom for the most stable structure of syn-CH3CHOO.	Oxygen	226-232	synemin	Homo sapiens	271-274
24410212-5	2014	The torsional barrier of the methyl top is fairly large in syn-CH3CHOO, implying a significant interaction between the terminal oxygen and the protons of the methyl moiety, which may be responsible for the high production yields of the OH radical from energized alkyl-substituted Criegee intermediates.	Oxygen	128-134	synemin	Homo sapiens	59-62
24383849-11	2014	A2B adenosine receptor stimulation (NECA) additionally led to increased CREB phosphorylation in trophoblast cells at 2% O2 (2.13 +- 0.45 fold), 8% O2 (1.55 +- 0.13 fold) and 21% O2 (1.71 +- 0.34 fold).	Oxygen	120-122	cAMP responsive element binding protein 1	Homo sapiens	72-76
25335240-6	2014	The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.	Oxygen	168-174	Salivary gland secretion 8	Drosophila melanogaster	75-83
24395659-1	2014	Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer.	Oxygen	122-124	neuroglobin	Homo sapiens	0-11
25803753-1	2014	The purpose of the current study was to determine the effects of three different pulse durations (200, 350, and 500 microseconds [P200, P350, and P500, respectively]) on oxygen uptake (VO2), cycling performance, and energy expenditure (EE) percentage of fatigue of the knee extensor muscle group immediately and 48 to 72 h after cycling in persons with spinal cord injury (SCI).	Oxygen	170-176	AT-rich interaction domain 2	Homo sapiens	130-134
23954488-1	2014	Echo-planar imaging (EPI) is a standard procedure in functional magnetic resonance imaging (fMRI) for measuring changes in the blood oxygen level-dependent (BOLD) signal associated with neuronal activity.	Oxygen	133-139	exocrine pancreatic insufficiency	Mus musculus	21-24
24598074-2	2014	Superoxide is produced by the NADPH-driven reduction of molecular oxygen, via a redox gradient located in Nox2.	Oxygen	66-72	cytochrome b-245 beta chain	Homo sapiens	106-110
24649711-0	2014	Effects of hyperbaric oxygen on the expression of endogenous matrix metalloproteinase 9 in rat lung tissue.	Oxygen	22-28	matrix metallopeptidase 9	Rattus norvegicus	61-87
24649711-1	2014	OBJECTIVE: To observe MMP9 expression in rat lungs under different degrees of hyperbaric oxygen (HBO2) exposure and to observe the relationship of tissue damage and apoptosis rate in the lung tissue.	Oxygen	89-95	matrix metallopeptidase 9	Rattus norvegicus	22-26
24649711-12	2014	CONCLUSIONS: MMP9 expression was elevated after exposure to hyperbaric oxygen.	Oxygen	71-77	matrix metallopeptidase 9	Rattus norvegicus	13-17
24279989-1	2013	Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the O2-dependent oxidation of l-cysteine (l-Cys) to produce cysteinesulfinic acid (CSA).	Oxygen	72-74	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
24436993-0	2013	Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury.	Oxygen	22-28	matrix metallopeptidase 9	Rattus norvegicus	42-47
24436993-1	2013	AIMS: To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI).	Oxygen	44-50	matrix metallopeptidase 9	Rattus norvegicus	78-83
24259416-1	2013	In Nature, the family of copper monooxygenases comprised of peptidylglycine alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DbetaM), and tyramine beta-monooxygenase (TbetaM) is known to perform dioxygen-dependent hydroxylation of aliphatic C-H bonds by using two uncoupled metal sites.	Oxygen	216-224	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	60-109
24259416-1	2013	In Nature, the family of copper monooxygenases comprised of peptidylglycine alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DbetaM), and tyramine beta-monooxygenase (TbetaM) is known to perform dioxygen-dependent hydroxylation of aliphatic C-H bonds by using two uncoupled metal sites.	Oxygen	216-224	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	111-114
24335635-0	2013	Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-kappaB expression.	Oxygen	11-17	high mobility group box 1	Rattus norvegicus	81-86
24335635-1	2013	STUDY DESIGN: We presented an insight into the effect of hyperbaric oxygen (HBO) on spinal cord injury (SCI), aiming to uncover the dynamics of high-mobility group protein B1 (HMGB1) and nuclear factor kappaB (NF-kappaB) after HBO intervention in rats with acute SCI.	Oxygen	68-74	high mobility group box 1	Rattus norvegicus	144-174
24335635-1	2013	STUDY DESIGN: We presented an insight into the effect of hyperbaric oxygen (HBO) on spinal cord injury (SCI), aiming to uncover the dynamics of high-mobility group protein B1 (HMGB1) and nuclear factor kappaB (NF-kappaB) after HBO intervention in rats with acute SCI.	Oxygen	68-74	high mobility group box 1	Rattus norvegicus	176-181
24339937-7	2013	Second, when the mto2 null and the mitochondrial C1477G mutations co-existed (mto2(P(R))), the oxygen consumption rate in the double mutant decreased markedly compared to that of the control strains (MTO2(P(S)), mto2(P(S)) and MTO2(P(R))).	Oxygen	95-101	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	17-21
24916903-9	2014	Conditioned media from lipocalin-2-treated astrocytes upregulated synaptotagmin, and conditioned media from lipocalin-2-treated microglia upregulated synaptophysin and post-synaptic density 95 (PSD95) and protected neurons against oxygen-glucose deprivation.	Oxygen	231-237	lipocalin 2	Homo sapiens	108-119
25286676-6	2014	RESULTS: HIF-1alpha mRNA in rat HSCs was induced after exposed to hypoxia for 3 h, and maintained elevated status up to 24 h. HSCs exposed to 1% O2 hypoxic conditions for 6 h increased alpha-SMA mRNA and protein expression.	Oxygen	145-147	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	9-19
24836121-0	2014	Strong photoluminescence enhancement of MoS(2) through defect engineering and oxygen bonding.	Oxygen	78-84	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	40-43
24914975-2	2014	Neuroglobin belongs to the heterogeneous group of hexacoordinate globins that have evolved in animals, plants and bacteria, endowed with the capability of reversible intramolecular coordination, allowing the binding of small gaseous ligands (O2, NO and CO).	Oxygen	242-244	neuroglobin	Homo sapiens	0-11
24627160-3	2014	This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells.	Oxygen	133-139	TSC complex subunit 2	Homo sapiens	70-74
24936444-5	2014	Pharmacological inhibition of NADPH oxidase, PKC-a, PKC-ss or PKC-ssI via their specific inhibitors and neutralisation of O2 ( -) by a cell-permeable superoxide dismutase mimetic, MnTBAP normalised all the aforementioned increases induced by hyperglycaemia.	Oxygen	122-124	2,4-dienoyl-CoA reductase 1	Homo sapiens	30-35
24648344-7	2014	We show that RHBDF1 interaction with the receptor of activated protein-C kinase-1 (RACK1) in breast cancer cells prevents RACK1-assisted, oxygen-independent HIF1alpha degradation.	Oxygen	138-144	receptor for activated C kinase 1	Homo sapiens	41-81
24648344-7	2014	We show that RHBDF1 interaction with the receptor of activated protein-C kinase-1 (RACK1) in breast cancer cells prevents RACK1-assisted, oxygen-independent HIF1alpha degradation.	Oxygen	138-144	receptor for activated C kinase 1	Homo sapiens	83-88
24648344-7	2014	We show that RHBDF1 interaction with the receptor of activated protein-C kinase-1 (RACK1) in breast cancer cells prevents RACK1-assisted, oxygen-independent HIF1alpha degradation.	Oxygen	138-144	receptor for activated C kinase 1	Homo sapiens	122-127
24887017-5	2014	RESULTS: In a primary cortical culture, HIF-1alpha expression was observed in neuronal somata after hypoxia (1% oxygen) in the presence of 5 or 25 mM glucose but not under normoxia (21% oxygen).	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-50
24887017-5	2014	RESULTS: In a primary cortical culture, HIF-1alpha expression was observed in neuronal somata after hypoxia (1% oxygen) in the presence of 5 or 25 mM glucose but not under normoxia (21% oxygen).	Oxygen	186-192	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-50
24685310-1	2014	Parvalbumin (PA) is a Ca(2+)-binding protein of vertebrates massively expressed in tissues with high oxygen uptake and respectively elevated level of reactive oxygen species (ROS).	Oxygen	101-107	parvalbumin	Rattus norvegicus	0-11
24685310-1	2014	Parvalbumin (PA) is a Ca(2+)-binding protein of vertebrates massively expressed in tissues with high oxygen uptake and respectively elevated level of reactive oxygen species (ROS).	Oxygen	101-107	parvalbumin	Rattus norvegicus	13-15
24379352-5	2014	Reduced oxygen consumption and impaired insulin action were recapitulated in Parkin-null myotubes, confirming a role for the HSP72-Parkin axis in the regulation of muscle insulin sensitivity.	Oxygen	8-14	heat shock protein 1A	Mus musculus	125-130
24553846-7	2014	In contrast to the wild type, the ratio of the PSI to the PSII ETR in pgr5 was higher in LL but lower in HL at 20% O2 due to PSI acceptor-side limitation.	Oxygen	115-117	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	63-66
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	Kruppel like factor 4	Homo sapiens	30-34
24320879-8	2014	Increased expression of cMyc, Klf4, Oct4, and Sox2 in 3% O2 is correlated with stabilization of both HIF1alpha and HIF2alpha.	Oxygen	57-59	SRY-box transcription factor 2	Homo sapiens	46-50
24320879-9	2014	The eye field development markers Pax6, Sox2, and Otx2 are present in hRPCs up to passage 16 in 3% O2 .	Oxygen	99-101	SRY-box transcription factor 2	Homo sapiens	40-44
24320879-9	2014	The eye field development markers Pax6, Sox2, and Otx2 are present in hRPCs up to passage 16 in 3% O2 .	Oxygen	99-101	orthodenticle homeobox 2	Homo sapiens	50-54
24777200-8	2014	Further experiments on oxygen-induced retinopathy (OIR) in mice revealed that eye drops containing large amounts of miR-410 efficiently downregulate VEGFA expression, prevent retinal angiogenesis and effectively treat RNV.	Oxygen	23-29	vascular endothelial growth factor A	Mus musculus	149-154
24603129-7	2014	The degree of oxygen-induced retinopathy was positively correlated with the VEGF expression level.	Oxygen	14-20	vascular endothelial growth factor A	Mus musculus	76-80
24518827-6	2014	C3G also attenuates HIF-1alpha protein accumulation conditions supporting the hypothesis of a major role of oxidative stress in the presence of low oxygen.	Oxygen	148-154	Rap guanine nucleotide exchange factor 1	Homo sapiens	0-3
24785057-5	2014	We find that the simulated filled-state STM images of surface-layer oxygen vacancies and fluorine impurities are essentially identical, which would render problematic their experimental distinction by such images alone.	Oxygen	68-74	sulfotransferase family 1A member 3	Homo sapiens	40-43
24785057-7	2014	Based on these results, we propose that the surface defects observed in STM experiments on CeO2 single crystals reported heretofore were not oxygen vacancies, but fluorine impurities.	Oxygen	141-147	sulfotransferase family 1A member 3	Homo sapiens	72-75
24785057-8	2014	Since the similarity of the simulated STM images of the two defects is due primarily to the relative energies of the 2p states of oxygen and fluorine ions, this confusion might also occur for other oxides which have been either doped or contaminated with fluorine.	Oxygen	130-136	sulfotransferase family 1A member 3	Homo sapiens	38-41
24707804-6	2014	Changes in the BDE with protonation state are reduced for alcohols with a connector group separating the oxygen center and the site of C-H bond scission.	Oxygen	105-111	homeobox D13	Homo sapiens	15-18
24743169-3	2014	Considering that elastin synthesis peaks in late fetal life in humans, and early postnatal life in rodents, we postulated that transient neonatal high-oxygen exposure can trigger premature vascular remodelling.	Oxygen	151-157	elastin	Homo sapiens	17-24
24743169-8	2014	In oxygen-exposed rats, aorta elastin/collagen content ratio was significantly decreased, the expression of elastinolytic cathepsin S was increased whereas collagenolytic cathepsin K was decreased.	Oxygen	3-9	elastin	Rattus norvegicus	30-37
24743169-9	2014	By immunofluorescence we observed an increase in MMP-2 and TIMP-1 staining in aortas of oxygen-exposed rats whereas TIMP-2 staining was reduced, indicating a shift in the balance towards degradation of the extra-cellular matrix and increased deposition of collagen.	Oxygen	88-94	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	59-65
24743169-11	2014	Overall, these findings indicate that transient neonatal high oxygen exposure leads to vascular wall alterations (decreased elastin/collagen ratio and a shift in the balance towards increased deposition of collagen) which are associated with increased rigidity.	Oxygen	62-68	elastin	Rattus norvegicus	124-131
24717514-12	2014	NNMT inhibition in adipocytes increases oxygen consumption in an ODC-, SSAT- and PAO-dependent manner.	Oxygen	40-46	nicotinamide N-methyltransferase	Mus musculus	0-4
24717514-12	2014	NNMT inhibition in adipocytes increases oxygen consumption in an ODC-, SSAT- and PAO-dependent manner.	Oxygen	40-46	ornithine decarboxylase, structural 1	Mus musculus	65-68
24519466-3	2014	Based on the GOx-mimicking enzyme activity, Au nanoparticles on the surface of the Fe3O4-Au nanocomposites effectively catalyzed the oxidization of glucose in the presence of dissolved O2, accompanied by the production of H2O2.	Oxygen	185-187	hydroxyacid oxidase 1	Homo sapiens	13-16
24550462-3	2014	We identify RPS23 hydroxylases as a highly conserved eukaryotic subfamily of Fe(II) and 2-oxoglutarate dependent oxygenases; their catalytic domain is closely related to transcription factor prolyl trans-4-hydroxylases that act as oxygen sensors in the hypoxic response in animals.	Oxygen	113-119	ribosomal protein S23	Homo sapiens	12-17
24492615-8	2014	Cellular bioenergetics analysis, metabolomics, and radiotracer studies demonstrated that GLUT1 overexpression resulted in elevated glucose uptake and metabolism, increased pentose phosphate pathway intermediates, with a complimentary reduction in cellular oxygen consumption rates.	Oxygen	256-262	solute carrier family 2 member 1	Homo sapiens	89-94
24623966-3	2014	Of these, NOX1 and NOX2 have been reported to contribute to intravitreal neovascularization (IVNV) in oxygen-induced retinopathy (OIR) models.	Oxygen	102-108	NADPH oxidase 1	Rattus norvegicus	10-14
24623966-3	2014	Of these, NOX1 and NOX2 have been reported to contribute to intravitreal neovascularization (IVNV) in oxygen-induced retinopathy (OIR) models.	Oxygen	102-108	cytochrome b-245 beta chain	Rattus norvegicus	19-23
24342540-1	2014	Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage.	Oxygen	48-54	hemoglobin subunit gamma 2	Homo sapiens	116-129
24342540-1	2014	Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage.	Oxygen	48-54	hemoglobin subunit gamma 2	Homo sapiens	131-136
24342540-5	2014	This study provides insight into a new design for Hb-oxygen based carriers with strongly inhibition of metHb formation in aqueous environment under aerobic conditions, even at physiological temperature in vitro.	Oxygen	53-59	hemoglobin subunit gamma 2	Homo sapiens	103-108
24221747-7	2014	New evidence indicates that a possible low oxygen tension resulting from increased metabolic rate and oxygen consumption may play a major role in stimulating glucose uptake and GLUT1 expression in mammary epithelial cells during lactogenesis.	Oxygen	43-49	solute carrier family 2 member 1	Homo sapiens	177-182
24221747-7	2014	New evidence indicates that a possible low oxygen tension resulting from increased metabolic rate and oxygen consumption may play a major role in stimulating glucose uptake and GLUT1 expression in mammary epithelial cells during lactogenesis.	Oxygen	102-108	solute carrier family 2 member 1	Homo sapiens	177-182
24146256-5	2014	PrrA, PpsR, and FnrL are global regulatory proteins mediating oxygen control of gene expression in this organism.	Oxygen	62-68	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	16-20
24586193-8	2014	Importantly, we show that variation in npr-1 causes each of these phenotypic differences through behavioral avoidance of ambient oxygen concentrations.	Oxygen	129-135	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	39-44
24339937-7	2013	Second, when the mto2 null and the mitochondrial C1477G mutations co-existed (mto2(P(R))), the oxygen consumption rate in the double mutant decreased markedly compared to that of the control strains (MTO2(P(S)), mto2(P(S)) and MTO2(P(R))).	Oxygen	95-101	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	78-82
24339937-7	2013	Second, when the mto2 null and the mitochondrial C1477G mutations co-existed (mto2(P(R))), the oxygen consumption rate in the double mutant decreased markedly compared to that of the control strains (MTO2(P(S)), mto2(P(S)) and MTO2(P(R))).	Oxygen	95-101	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	200-204
24339937-7	2013	Second, when the mto2 null and the mitochondrial C1477G mutations co-existed (mto2(P(R))), the oxygen consumption rate in the double mutant decreased markedly compared to that of the control strains (MTO2(P(S)), mto2(P(S)) and MTO2(P(R))).	Oxygen	95-101	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	78-82
23884959-3	2013	Under pathological hypoxia, the catalytic activities of JMJD2A, JMJD2C and Jumonji/ARID domain-containing protein 1B (JARID1B) were blocked due to the lack of their substrate, i.e. oxygen.	Oxygen	181-187	lysine demethylase 4A	Homo sapiens	56-62
23884959-3	2013	Under pathological hypoxia, the catalytic activities of JMJD2A, JMJD2C and Jumonji/ARID domain-containing protein 1B (JARID1B) were blocked due to the lack of their substrate, i.e. oxygen.	Oxygen	181-187	lysine demethylase 4C	Homo sapiens	64-70
23884893-4	2013	In the oxygen-induced retinopathy (OIR) model, kallistatin overexpression attenuated ischemia-induced retinal neovascularization.	Oxygen	7-13	serpin family A member 4	Homo sapiens	47-58
24157525-5	2013	Performing simultaneous voltage clamp and O2 measurements, we found that acute hypoxia gradually and reversibly suppressed the Ca(2+) channel (CaV1.2).	Oxygen	42-44	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	143-149
24244514-6	2013	Our results demonstrate that exposure to hypoxia (10% O2) for 3-weeks increased levels of miR-27a and ET-1 in the lungs of C57BL/6 mice and reduced PPARgamma levels.	Oxygen	54-56	microRNA 27a	Mus musculus	90-97
24244340-4	2013	Here we show that ECs transfected with a S100A1-3" untranslated region (UTR) luciferase reporter construct display significantly reduced gene expression when subjected to low oxygen levels or chemical hypoxia.	Oxygen	175-181	S100 calcium binding protein A13	Homo sapiens	41-49
24413863-11	2013	Besides, serum GGT levels were significantly correlated with AHI, oxygen desaturation index, and average and minimum O2 saturation values (P &lt; .05).	Oxygen	66-72	gamma-glutamyltransferase 1	Homo sapiens	15-18
24413863-11	2013	Besides, serum GGT levels were significantly correlated with AHI, oxygen desaturation index, and average and minimum O2 saturation values (P &lt; .05).	Oxygen	117-119	gamma-glutamyltransferase 1	Homo sapiens	15-18
24475977-5	2013	After oxygen therapy, the blood methemoglobin concentration level decreased to 2.1%, and the symptoms were alleviated.	Oxygen	6-12	hemoglobin subunit gamma 2	Homo sapiens	32-45
24134622-4	2014	Exposure of hASCs for 10 days under hypoxia (3% oxygen) in combination with leptin increased the percentage of CD31(+) endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor, and endothelial cell nitric oxide synthase mRNA expression.	Oxygen	48-54	kinase insert domain receptor	Homo sapiens	167-172
24066808-3	2014	We determined that sustained NF-kappaB activity mediated by IkappaBbeta attenuates lung injury and prevents mortality in adult mice exposed to greater than 95% O2.	Oxygen	160-162	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	60-71
23919619-11	2014	Thus, the Ero1alpha/GPx7/PDI triad generates two disulfide bonds and two H2O molecules at the expense of a single O2 molecule.	Oxygen	114-116	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	10-19
23508863-7	2013	Glucose oxidase (GOx), which is a redox enzyme capable of oxidizing glucose as a renewable fuel using oxygen, was immobilized on the CL-CNT composite paper.	Oxygen	102-108	hydroxyacid oxidase 1	Homo sapiens	0-15
10920257-6	2000	The low affinity of homarine (N-methylpicolinate) for oxidized DAO, as in the case of o-methylbenzoate, is due to steric hindrance: one of the ortho carbons of benzoate is near the phenol carbons of Tyr228 and the other ortho carbon is near the carbonyl oxygen of Gly313.	Oxygen	254-260	D-amino acid oxidase	Homo sapiens	63-66
23508863-7	2013	Glucose oxidase (GOx), which is a redox enzyme capable of oxidizing glucose as a renewable fuel using oxygen, was immobilized on the CL-CNT composite paper.	Oxygen	102-108	hydroxyacid oxidase 1	Homo sapiens	17-20
24510989-4	2014	HIF1 is a heterodimeric transcriptional complex that functions as the main regulator of systemic and cellular oxygen homeostasis; it is composed of HIF1alpha and HF1beta subunits.	Oxygen	110-116	Sp4 transcription factor	Homo sapiens	162-169
10946870-7	2000	These results suggest that NO blocks hypoxic induction of IGFBP-1 by a guanylate cyclase/ cGMP-independent pathway, possibly at the level of oxygen sensing.	Oxygen	141-147	insulin like growth factor binding protein 1	Homo sapiens	58-65
24184535-2	2014	SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of catalase to disproportionate H2O2 to O2, and has obvious effect on the proliferation of HepG-2 cells in 72 h. Moreover, the two nanoparticles show some inhibition on the expression of hypoxia inducible factor (HIF-1alpha), glucose transporter (GLUT1) and the production of lactate in HepG-2 cells.	Oxygen	2-4	solute carrier family 2 member 1	Homo sapiens	354-359
25076541-4	2014	The efficiency of M-NZVI in removing BDE-209 decreased as the pH and the initial dissolved oxygen content of the reaction solution increased, but increased as the proportion of water in the reaction solution increased.	Oxygen	91-97	homeobox D13	Homo sapiens	37-40
23625881-7	2013	Meanwhile, expression of GPD1 decreased due to the depletion of dissolved oxygen in the fermentation broth, but expression of GPD2 correlated with ORP.	Oxygen	74-80	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	25-29
23765637-0	2013	In vitro effects of IL-17 on angiogenic properties of endothelial cells in relation to oxygen levels.	Oxygen	87-93	interleukin 17A	Homo sapiens	20-25
23765637-1	2013	The aim of this study has been to elucidate how different oxygen levels impact the effects of Interleukin-17 (IL-17) on angiogenic properties of endothelial cells.	Oxygen	58-64	interleukin 17A	Homo sapiens	94-108
10947063-4	2000	Theophylline potentiates O2(-) production via adenosine A(2A) receptor antagonism induced by receptor-linked agonists from neutrophils, but not from eosinophils.	Oxygen	25-27	adenosine A2a receptor	Homo sapiens	46-70
23765637-1	2013	The aim of this study has been to elucidate how different oxygen levels impact the effects of Interleukin-17 (IL-17) on angiogenic properties of endothelial cells.	Oxygen	58-64	interleukin 17A	Homo sapiens	110-115
23765637-5	2013	When cultured at 20% O2 , IL-17 stimulated proliferation, migration and tubulogenesis, whereas a hypoxic environment did not affect their migration and proliferation, but increased their survival and tubulogenic properties.	Oxygen	21-23	interleukin 17A	Homo sapiens	26-31
23765637-8	2013	At 20% O2 , IL-17 did not alter their proliferation,but inhibited migration and stimulated tubule formation.	Oxygen	7-9	interleukin 17A	Homo sapiens	12-17
23765637-11	2013	Thus the effects of IL-17 on the angiogenic properties of endothelial cells depend on both the cell line used and the oxygen concentration.	Oxygen	118-124	interleukin 17A	Homo sapiens	20-25
24498060-4	2014	We found decreased apoptosis in doxorubicin-treated cells expressing NDRG1 shRNAs under normoxia, demonstrating a requirement for NDRG1 in apoptosis in breast epithelial cells under normal oxygen pressure.	Oxygen	189-195	N-myc downstream regulated 1	Homo sapiens	69-74
10887204-1	2000	Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine.	Oxygen	85-91	dopamine beta-hydroxylase	Homo sapiens	0-25
24051299-11	2014	Raman spectroscopy, (31)P NMR and DFT calculations (DFT:B3LYP/6-311++G(**)) indicated that the donor atoms are oxygen in the phosphate group, the nitrogen of the guanidine group and the oxygen of the carboxylate group.	Oxygen	111-117	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	58-61
24351177-1	2013	BACKGROUND: Partial pressure of oxygen (pO2) in blood samples can affect blood glucose (BG) measurements, particularly in systems that employ the glucose oxidase (GOx) enzyme reaction on test strips.	Oxygen	32-38	hydroxyacid oxidase 1	Homo sapiens	146-161
24351177-1	2013	BACKGROUND: Partial pressure of oxygen (pO2) in blood samples can affect blood glucose (BG) measurements, particularly in systems that employ the glucose oxidase (GOx) enzyme reaction on test strips.	Oxygen	32-38	hydroxyacid oxidase 1	Homo sapiens	163-166
24351177-3	2013	Two of the GOx systems are labeled by the manufacturers to be sensitive to increased blood oxygen content, while the other three GOx systems are not.	Oxygen	91-97	hydroxyacid oxidase 1	Homo sapiens	11-14
10887204-1	2000	Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine.	Oxygen	85-91	dopamine beta-hydroxylase	Homo sapiens	27-33
23979836-2	2013	The traditional biological function of HIF-1alpha is promoting the transcription of some pro-survival genes when exposing to low oxygen conditions.	Oxygen	129-135	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	39-49
24092939-16	2013	Elevated K1(FDHROL) in the SHR may reflect elevated oxygen consumption and decreased capillary density in the hypertrophied heart.	Oxygen	52-58	keratin 1	Rattus norvegicus	9-19
24466275-5	2014	We found the ectopic overexpression of miR-122 affected metabolic activities of HCC cells, evidenced by the reduced lactate production and increased oxygen consumption.	Oxygen	149-155	microRNA 122	Homo sapiens	39-46
24188852-5	2014	In particular, the composite film of 85% cellulose and 15% MTM has the highest tensile strength and Young"s modulus 161 and 180% greater than those of the 100% cellulose film, and coefficient of thermal expansion and oxygen permeability at 50-75% RH decrease to 60 and 42-33%, respectively.	Oxygen	217-223	metallothionein 1D, pseudogene	Homo sapiens	59-62
23999071-8	2013	Reoxygenation with 100% oxygen after hypoxia uniquely upregulated Gadd45g, Dusp1, Peg3, and Tgm2.	Oxygen	2-8	growth arrest and DNA-damage-inducible 45 gamma	Mus musculus	66-73
10962209-4	2000	The specific objective of this study was to determine whether cytochrome c in the flight muscle mitochondria of the housefly is oxidatively damaged during aging and/or under severe oxidative stress induced by exposure of flies to 100% oxygen.	Oxygen	235-241	cytochrome c	Musca domestica	62-74
23972287-10	2013	In addition, the hypoxic condition (2% O2) increased LCN2 expression (p &lt; 0.01), MMP-9 activity, and invasive ability (p &lt; 0.01).	Oxygen	39-41	lipocalin 2	Homo sapiens	53-57
23972287-10	2013	In addition, the hypoxic condition (2% O2) increased LCN2 expression (p &lt; 0.01), MMP-9 activity, and invasive ability (p &lt; 0.01).	Oxygen	39-41	matrix metallopeptidase 9	Homo sapiens	84-89
24274759-2	2014	The voltammetric studies showed that, regardless of CHIT matrix, the GOx adsorbed on CNT yielding a pair of surface-confined current peaks at -0.48 V. The anodic peak did not increase in the presence of glucose in an O2-free solution indicating the lack of direct electron transfer (DET) between the enzymatically active GOx and CNT.	Oxygen	217-219	hydroxyacid oxidase 1	Homo sapiens	69-72
24339041-0	2014	Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymes.	Oxygen	51-57	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	102-106
10841535-2	2000	We have experimentally mimicked starting points in this process by introducing primitive iron and oxygen binding sites at various locations in thioredoxin, a small protein lacking metal centers, by using computational design.	Oxygen	98-104	thioredoxin	Homo sapiens	143-154
24184117-4	2014	Genetic deletion of beta2-nAChRs associated with reduced terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL(+)) and cleaved caspase-3(+) cells after MCAO, together with a reduction of extracellular glutamate and oxygen-glucose deprivation-induced increase of excitatory inputs in cortical neurons.	Oxygen	244-250	DNA nucleotidylexotransferase	Homo sapiens	57-94
24184117-4	2014	Genetic deletion of beta2-nAChRs associated with reduced terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL(+)) and cleaved caspase-3(+) cells after MCAO, together with a reduction of extracellular glutamate and oxygen-glucose deprivation-induced increase of excitatory inputs in cortical neurons.	Oxygen	244-250	DNA nucleotidylexotransferase	Homo sapiens	96-99
24011442-9	2013	CONCLUSIONS: Patients with IUGR have increased trophoblast expression of GLUT3, as found under the low-oxygen conditions of the first trimester.	Oxygen	103-109	solute carrier family 2 member 3	Homo sapiens	73-78
10872610-10	2000	CONCLUSIONS: The up-regulation of VEGF isoforms during the progression of uterine-peritoneal adhesion may be a compensatory mechanism regulating angiogenesis in order to provide nutrients and oxygen to the injured tissues.	Oxygen	192-198	vascular endothelial growth factor A	Rattus norvegicus	34-38
23934926-6	2013	However, following mild lung injury caused by breathing 70% O2, the sGC-alpha1 KO mouse pups had pronounced inhibition of alveolarization, as evidenced by an increase in airway mean linear intercept, reduction in terminal airway units, and decrease in lung septation and alveolar openings, as well as reduced somatic growth.	Oxygen	60-62	guanylate cyclase 1, soluble, alpha 1	Mus musculus	68-78
23978105-1	2014	The key oxygen sensing molecules, Prolyl-hydroxylase domain 1-3 enzymes (PHD1-3), regulate hypoxia-inducible factor (HIF) under hypoxia.	Oxygen	8-14	egl-9 family hypoxia-inducible factor 2	Mus musculus	73-79
10783335-3	2000	A body of evidence points to: (i) oxygen hypersensitivity of FA cells; (ii) oxygen-dependent MMC and DEB toxicity; (iii) excess oxidative DNA damage in FA cells; and (iv) DEB-induced glutathione depletion and GST inhibition.	Oxygen	34-40	glutathione S-transferase kappa 1	Homo sapiens	209-212
24502349-0	2014	A new (G)gamma-globin variant causing low oxygen affinity: Hb F-Brugine/Feldkirch [(G)gamma105(G7)Leu His; HBG2: c.317T&gt;A].	Oxygen	42-48	hemoglobin subunit gamma 2	Homo sapiens	107-111
24084221-1	2014	This study describes the effect of variable oxygen supply on relaxing responses induced by alpha-calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) on isolated pig coronary arteries in vitro.	Oxygen	44-50	Calcitonin gene-related peptide	Sus scrofa	91-128
24084221-1	2014	This study describes the effect of variable oxygen supply on relaxing responses induced by alpha-calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) on isolated pig coronary arteries in vitro.	Oxygen	44-50	Calcitonin gene-related peptide	Sus scrofa	130-134
23834247-7	2013	Furthermore, our oxygen consumption results suggested that the Fe-S-containing Mia40 is not an electron donor for Erv1.	Oxygen	17-23	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	79-84
23897395-2	2013	The N-MCS cathode shows excellent discharge performance in lithium-oxygen batteries.	Oxygen	67-73	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	6-9
10783335-3	2000	A body of evidence points to: (i) oxygen hypersensitivity of FA cells; (ii) oxygen-dependent MMC and DEB toxicity; (iii) excess oxidative DNA damage in FA cells; and (iv) DEB-induced glutathione depletion and GST inhibition.	Oxygen	76-82	glutathione S-transferase kappa 1	Homo sapiens	209-212
10756076-0	2000	Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain.	Oxygen	41-47	erythropoietin	Mus musculus	31-34
24001219-2	2013	A crystal structure of the hepatitis delta virus (HDV) ribozyme suggested that the pro-RP oxygen at the scissile phosphate directly coordinates a catalytic Mg(2+) ion and is within hydrogen bonding distance of the amine of the general acid C75.	Oxygen	90-96	protein only RNase P catalytic subunit	Homo sapiens	83-89
24001219-10	2013	This metal ion rescue suggests a direct interaction of the catalytic metal ion with the pro-RP oxygen, in line with experiments with the antigenomic HDV ribozyme.	Oxygen	95-101	protein only RNase P catalytic subunit	Homo sapiens	88-94
24001219-11	2013	Experiments without divalent ions, with a double mutant that interferes with Mg(2+) binding, or with C75 deleted suggest that the pro-RP oxygen plays at most a redundant role in positioning C75.	Oxygen	137-143	protein only RNase P catalytic subunit	Homo sapiens	130-136
24001219-12	2013	Quantum mechanical/molecular mechanical (QM/MM) studies indicate that the metal ion contributes to catalysis by interacting with both the pro-RP oxygen and the nucleophilic 2"-hydroxyl, supporting the experimental findings.	Oxygen	145-151	protein only RNase P catalytic subunit	Homo sapiens	138-144
23045284-0	2013	Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2.	Oxygen	15-21	caudal type homeobox 2	Homo sapiens	149-153
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	mitochondrially encoded cytochrome b	Homo sapiens	142-154
24504963-1	2014	The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac.	Oxygen	16-18	cytochrome b-245 beta chain	Homo sapiens	174-178
24504963-3	2014	A consequent conformational change in Nox2 initiates the electron "flow" along a redox gradient, from NADPH to oxygen, leading to the one-electron reduction of molecular oxygen to O2 ( -).	Oxygen	111-117	cytochrome b-245 beta chain	Homo sapiens	38-42
24504963-3	2014	A consequent conformational change in Nox2 initiates the electron "flow" along a redox gradient, from NADPH to oxygen, leading to the one-electron reduction of molecular oxygen to O2 ( -).	Oxygen	170-176	cytochrome b-245 beta chain	Homo sapiens	38-42
24504963-3	2014	A consequent conformational change in Nox2 initiates the electron "flow" along a redox gradient, from NADPH to oxygen, leading to the one-electron reduction of molecular oxygen to O2 ( -).	Oxygen	180-182	cytochrome b-245 beta chain	Homo sapiens	38-42
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	68-99
24685982-7	2014	Oxygen deprivation increased gene expression of aquaporin-4 (AQP4), hypoxia-inducible factor 1alpha (Hif1alpha), and cyclooxygenase-2 (COX2).	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	101-110
24746056-5	2014	Somatostatin modestly but significantly (p&lt;0.05) reduced CO2 output, but not O2 uptake.	Oxygen	61-63	somatostatin	Homo sapiens	0-12
10756076-7	2000	These data indicate that, following hypoxia, a common oxygen sensing and signaling pathway leads to increased Epo gene expression in both nervous and hepatoma cells; this pathway would be dependent on the redox-state of the brain.	Oxygen	54-60	erythropoietin	Mus musculus	110-113
24741770-2	2014	Studies have revealed that mutant huntingtin, polyglutamine-expanded ataxin-1 and ataxin-3 can cause elevated levels of reactive oxygen species in neuronal cells.	Oxygen	129-135	ataxin 3	Homo sapiens	82-90
23880665-1	2013	The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal degradation of the labile subunit HIF1A.	Oxygen	57-63	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	120-125
23880665-9	2013	This new pathway for degradation of HIF1A does not depend on the presence of oxygen and is activated in response to nutrient deprivation such that the levels of HIF1A bound to CMA positive lysosomes significantly increase in starved animal livers and the binding of HIF1A to LAMP2A increases in response to serum deprivation.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	36-41
11043930-5	2000	The modulation of the O2 affinity of these cross-bridged HbS in the presence of allosteric effectors, DPG and L-35, is also very distinct, reflecting the differences in the conformational features these two cross-bridges induce within the central cavity at the respective effector-binding domains.	Oxygen	22-24	ribosomal protein L35	Homo sapiens	110-114
28811451-4	2013	The geometry of the Ca(II) ion is a distorted CaNO6 pengonal bipyramid, arising from its coordination by four water molecules, one nitrogen atom of 4,4"-bipyridyl molecule, and two oxygen atoms from two L ligands.	Oxygen	181-187	carbonic anhydrase 2	Homo sapiens	20-26
25201196-0	2014	Crosstalk between Mdm2, p53 and HIF1-alpha: distinct responses to oxygen stress and implications for tumour hypoxia.	Oxygen	66-72	MDM2 proto-oncogene	Homo sapiens	18-22
24252224-9	2014	Expression of nestin mRNA (NES) was significantly increased after neurosphere culture and was significantly higher in 1% O2 compared to 5% and 21% O2.	Oxygen	121-123	nestin	Canis lupus familiaris	14-20
24252224-9	2014	Expression of nestin mRNA (NES) was significantly increased after neurosphere culture and was significantly higher in 1% O2 compared to 5% and 21% O2.	Oxygen	147-149	nestin	Canis lupus familiaris	14-20
24252224-10	2014	Neurospheres cultured in 1% O2 had significantly increased levels of VEGF and EPOR.	Oxygen	28-30	vascular endothelial growth factor A	Canis lupus familiaris	69-73
10727416-6	2000	Only a modest increase in intracellular oxygen species was found in thymocytes stimulated by strong cross-linking of TCR together with CD4 or CD28.	Oxygen	40-46	T cell receptor alpha variable 6-3	Mus musculus	117-120
24741968-0	2014	[Changes of PKC in rat lung exposed to 2.3 ATA hyperbaric oxygen in different times].	Oxygen	58-64	protein kinase C, gamma	Rattus norvegicus	12-15
23766263-4	2013	APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia.	Oxygen	97-99	semaphorin 3A	Rattus norvegicus	233-239
23766263-8	2013	CONCLUSIONS: Our findings suggest that in the early stages of O2-induced retinopathy, retinal microglia are activated to produce IL-1beta, which sustains the activation of microglia and induces microvascular injury through the release of Sema3A from adjacent neurons.	Oxygen	62-64	semaphorin 3A	Rattus norvegicus	238-244
10727416-6	2000	Only a modest increase in intracellular oxygen species was found in thymocytes stimulated by strong cross-linking of TCR together with CD4 or CD28.	Oxygen	40-46	CD28 antigen	Mus musculus	142-146
23477542-11	2013	We implicate an elevated O2(-):H2O2 ratio as a prosurvival signal in GPC self-renewal and proliferation.	Oxygen	25-27	glycophorin C (Gerbich blood group)	Homo sapiens	69-72
23731227-8	2013	Minocycline, tetramethylpyrazine, and hyperbaric oxygen treatment all increase IL-10 levels in a SCI models and result in increased tissue sparing and functional recovery.	Oxygen	49-55	interleukin 10	Homo sapiens	79-84
10938860-0	2000	Mechanism of peroxidase actions for salicylic acid-induced generation of active oxygen species and an increase in cytosolic calcium in tobacco cell suspension culture.	Oxygen	80-86	peroxidase N1	Nicotiana tabacum	13-23
25206655-6	2013	Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was significantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy.	Oxygen	271-277	carbonic anhydrase 3	Rattus norvegicus	125-128
25206655-8	2013	Our findings indicate that hyperbaric oxygen therapy significantly improves cognitive functioning in rats with traumatic brain injury, and the potential mechanism is mediated by metabolic changes and nerve cell restoration in the hippocampal CA3 region.	Oxygen	38-44	carbonic anhydrase 3	Rattus norvegicus	242-245
23789854-2	2013	In this article, we revise some recent results on the stability diagrams of spin states, low, high, or intermediate, in distorted environments and extend their approach to redraw more realistic diagrams for d(4), d(5), and d(6) ions in a tetragonally distorted 6-fold oxygen environment (D4h, D2d, and C4nu).	Oxygen	268-274	spindlin 1	Homo sapiens	76-80
22986523-5	2013	Cells lacking E6AP expression have reduced capacity to accumulate ROS, and oxidative DNA damage, in response to 20% cell culture oxygen levels, treatment with hydrogen peroxide and expression of oncogenic RAS.	Oxygen	129-135	ubiquitin protein ligase E3A	Homo sapiens	14-18
24349516-7	2013	Furthermore, there were differential changes in levels of beclin-1, DRAM, and LC3B-II in response to changes in oxygen and glucose levels.	Oxygen	112-118	beclin 1	Homo sapiens	58-66
24312588-9	2013	The S100beta concentrations, which increased significantly after CO poisoning, increased at a much slower rate in the rats treated with HOS (HOS group) compared with the rats treated with O2 inhalation (O2 group).	Oxygen	203-205	S100 calcium binding protein B	Rattus norvegicus	4-12
10734219-4	2000	In this study, a SixA-deficient mutant was characterized with special reference to the ArcB signaling, which allows E. coli cells to respond to not only external oxygen, but also certain anaerobic respiratory conditions.	Oxygen	162-168	hypothetical protein	Escherichia coli	87-91
24316821-4	2013	The plant blue-light photoreceptors phototropins possess two N-terminal flavin mononucleotide-based light, oxygen or voltage (LOV) domains (LOV1 and LOV2) that comprise a subclass of the PAS family and one C-terminal serine/threonine kinase domain whose enzymatic activity is regulated by blue light.	Oxygen	107-113	NAC domain containing protein 35	Arabidopsis thaliana	140-144
23880643-6	2013	Of 71 proteins identified, five proteins involved in extracellular matrix (ECM) remodeling exhibited &gt;=2-fold decrease under low O2 culture and were confirmed by Western immunoblot and qRT-PCR: fibronectin 1, TGF-beta1-induced protein (betaig-h3), osteonectin, and collagens type 1alpha1 and alpha2.	Oxygen	132-134	transforming growth factor beta induced	Homo sapiens	239-248
23829766-5	2013	This insight derived through a detailed quantitative analysis of the stereocontrolling transition states suggests that the commonly found interpretations solely based on steric interactions between the incoming oxygen and the protruding angular methyl groups (C10, C13 methyls) in the beta face calls for adequate refinement.	Oxygen	211-217	homeobox C13	Homo sapiens	265-268
23815594-9	2013	IL-10 (-1082, -819, -592) ACC haplotype was associated with the diffusion capacity of the lung for carbon monoxide, and ATA haplotype was associated with the partial pressure of oxygen (PaO2) (all p &lt; 0.05).	Oxygen	178-184	interleukin 10	Homo sapiens	0-5
10710528-1	2000	Previous studies have shown that lungs of adult mice exposed to &gt;95% oxygen have increased terminal deoxyribonucleotidyltransferase dUTP nick end-label staining and accumulate p53, the expression of which increases in cells exposed to DNA-damaging agents.	Oxygen	72-78	transformation related protein 53, pseudogene	Mus musculus	179-182
23385656-12	2013	A simulated dive at 60 kPa O2 had a potentiating effect on the heat-induced HSP70 expression, whereas GSH levels were unaffected by hyperoxic exposure.	Oxygen	27-29	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
23611872-0	2013	In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.	Oxygen	78-84	aquaporin 4	Mus musculus	54-65
24290922-9	2013	The molecular docking and MD simulation studies showed that the sulfhydryl hydrogen atom of Cys17 of cysteine protease interacts with carboxylic oxygen of Lys16 of Abeta peptide indicating the cleavage site.	Oxygen	145-151	cathepsin B	Homo sapiens	101-118
24298056-2	2013	Using transgenic mouse models, we demonstrate that deletion of the von Hippel-Lindau (Vhlh) gene (encoding an E3 ubiquitin ligase implicated in, among other functions, oxygen sensing in pancreatic beta cells) is deleterious to canonical beta-cell gene expression.	Oxygen	168-174	von Hippel-Lindau tumor suppressor	Mus musculus	86-90
23611872-4	2013	These observations suggest that K(+) uptake is suppressed in Aqp4(-/-) mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations.	Oxygen	106-112	aquaporin 4	Mus musculus	61-65
10671489-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) and the HIF-like factor (HLF) are two highly related basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) homology transcription factors that undergo dramatically increased function at low oxygen levels.	Oxygen	228-234	HLF transcription factor, PAR bZIP family member	Homo sapiens	53-68
23611872-4	2013	These observations suggest that K(+) uptake is suppressed in Aqp4(-/-) mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations.	Oxygen	182-188	aquaporin 4	Mus musculus	61-65
23611872-4	2013	These observations suggest that K(+) uptake is suppressed in Aqp4(-/-) mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations.	Oxygen	182-188	aquaporin 4	Mus musculus	61-65
24012990-1	2013	In previous calculations of how the O2 transport system limits .VO2(max), it was reasonably assumed that mitochondrial P(O2) (Pm(O2)) could be neglected (set to zero).	Oxygen	36-38	immunoglobulin kappa variable 1D-39	Homo sapiens	105-123
10671489-1	2000	Hypoxia-inducible factor 1alpha (HIF-1alpha) and the HIF-like factor (HLF) are two highly related basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) homology transcription factors that undergo dramatically increased function at low oxygen levels.	Oxygen	228-234	HLF transcription factor, PAR bZIP family member	Homo sapiens	70-73
10772875-2	2000	Upon activation of this multicomponent system, p47-phox translocates to the membrane and participates in the electron transfer from NADPH to molecular oxygen.	Oxygen	151-157	pleckstrin	Homo sapiens	47-50
24260556-0	2013	Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta.	Oxygen	52-58	kinase insert domain receptor	Homo sapiens	15-22
24260556-7	2013	VEGFR-2 transcript and protein levels from explants cultured in 3% O2 were significantly decreased compared to those incubated at 20% O2 (5.9 and 12.47 fold, respectively).	Oxygen	67-69	kinase insert domain receptor	Homo sapiens	0-7
24260556-7	2013	VEGFR-2 transcript and protein levels from explants cultured in 3% O2 were significantly decreased compared to those incubated at 20% O2 (5.9 and 12.47 fold, respectively).	Oxygen	134-136	kinase insert domain receptor	Homo sapiens	0-7
24260556-8	2013	Also, VEGFR-2 transcript levels were significantly decreased in early first trimester placentae (low oxygen environment) compared to late first trimester placentae (2.05 fold).	Oxygen	101-107	kinase insert domain receptor	Homo sapiens	6-13
23692052-4	2013	In this work, X-ray absorption spectroscopy (XAS) has been used to investigate the Fe(II) active site of truncated JMJD2A and JMJD2C (1-350 amino acids) in the presence and absence of alphaKG and/or substrate to obtain mechanistic details of the early steps in catalysis that precede O2 binding in histone demethylation by the JMJD2 family of histone demethylases.	Oxygen	284-286	lysine demethylase 4A	Homo sapiens	115-121
23692052-4	2013	In this work, X-ray absorption spectroscopy (XAS) has been used to investigate the Fe(II) active site of truncated JMJD2A and JMJD2C (1-350 amino acids) in the presence and absence of alphaKG and/or substrate to obtain mechanistic details of the early steps in catalysis that precede O2 binding in histone demethylation by the JMJD2 family of histone demethylases.	Oxygen	284-286	lysine demethylase 4A	Homo sapiens	115-120
23562599-5	2013	An increase in Map2 immunostaining was only observed when fibroblasts experienced an acute drop in O2 tension upon infection.	Oxygen	99-101	microtubule associated protein 2	Homo sapiens	15-19
23799003-11	2013	However, oxygen consumption rates were generally lower in the ADPGK knockouts, in some cases markedly so.	Oxygen	9-15	ADP dependent glucokinase	Homo sapiens	62-67
24049118-9	2013	Catecholaminergic cells colabeled with Fos immunoreactivity in the CVLM were observed following 12% O2, and further increases in hypoxia severity caused markedly more activation.	Oxygen	100-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-42
24072708-9	2013	Indicative of a direct regulatory role for Them2 in heat production, cultured primary brown adipocytes from Them2(-/-) mice exhibited increased norepinephrine-mediated triglyceride hydrolysis and increased rates of O2 consumption, together with elevated expression of thermogenic genes.	Oxygen	215-217	acyl-CoA thioesterase 13	Mus musculus	108-113
10651825-2	2000	In mitochondria isolated from potato (Solanum tuberosum L.) tuber callus, stimulation of the rate of oxygen uptake was accompanied by a decrease in the steady-state reduction level of coenzyme Q, and by a small decrease in the steady-state reduction level of cytochrome c.	Oxygen	101-107	cytochrome c	Solanum tuberosum	259-271
24222487-14	2013	We show here that S. aureus achieves hmp regulation in response to nitric oxide and oxygen limitation by placing it under the control of the SrrAB two-component system, which senses reduced electron flow through the respiratory chain.	Oxygen	84-90	inner membrane mitochondrial protein	Homo sapiens	37-40
23758895-4	2013	Notably, its protein stability is controlled by the oxygen sensing prolyl hydroxylase domain (PHD) enzymes and its transcriptional activity is controlled by the asparaginyl hydroxylase FIH (factor inhibiting HIF-1).To probe the complexity of hypoxia-induced HIF signalling, efforts in mathematical modelling of the pathway have been underway for around a decade.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	190-213
10695661-0	2000	Inhibition of MIP-1alpha-induced human neutrophil and monocyte chemotactic activity by reactive oxygen and nitrogen metabolites.	Oxygen	96-102	C-C motif chemokine ligand 3	Homo sapiens	14-24
23599441-6	2013	In vitro, Ntn1 and Unc5b mRNA are upregulated in macrophages treated with oxidized low-density lipoprotein or inducers of oxidative stress (CoCl2, dimethyloxalylglycine, 1% O2).	Oxygen	173-175	netrin 1	Homo sapiens	10-14
23599441-6	2013	In vitro, Ntn1 and Unc5b mRNA are upregulated in macrophages treated with oxidized low-density lipoprotein or inducers of oxidative stress (CoCl2, dimethyloxalylglycine, 1% O2).	Oxygen	173-175	unc-5 netrin receptor B	Homo sapiens	19-24
24244317-3	2013	Conformationally constrained phenethylamine analogs have demonstrated that for optimal activity the free lone pair electrons of the 2-oxygen must be oriented syn and the 5-oxygen lone pairs anti relative to the ethylamine moiety.	Oxygen	134-140	synemin	Homo sapiens	158-161
24164682-1	2013	The protonation-reduction of a dioxygen adduct with [LCu(I)][B(C6F5)4], cupric superoxo complex [LCu(II)(O2( -))]+ (1) (L = TMG3tren (1,1,1-tris[2-[N(2)-(1,1,3,3-tetramethylguanidino)]ethyl]amine)) has been investigated.	Oxygen	31-39	proline rich and Gla domain 3	Homo sapiens	124-128
23330917-4	2013	Quantification of accA-like genes revealed a consistent depth profile in the upper mesopelagial with increasing gene abundances from subsurface layers towards the oxygen minimum zone (OMZ), coinciding with an increase in archaeal amoA gene abundance.	Oxygen	163-169	acetyl-CoA carboxylase alpha	Homo sapiens	18-22
10771792-1	2000	The NOTT study showed improved survival in COT patients who received LTOT for longer periods (mean 17.7 h/d, median 19.4 h/d) from an ambulatory oxygen system, compared with the survival of NOT patients who received oxygen for a mean of 11.8 h/d from a stationary system.	Oxygen	145-151	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	43-46
23671091-5	2013	In addition, we find that hypoxic cells bypass de novo lipogenesis, and thus, both the need for acetyl-CoA and the oxygen-dependent SCD1-reaction, by scavenging serum fatty acids.	Oxygen	115-121	stearoyl-CoA desaturase	Homo sapiens	132-136
24105420-9	2013	Based on these results, we hypothesize that in the hearts of exercised animals, eNOS uncoupling associated with the improved myocardial antioxidant capacity prevents excessive NO synthesis and limits the reaction between NO and O2 - to form peroxynitrite (ONOO-), which is cytotoxic.	Oxygen	228-230	nitric oxide synthase 3	Rattus norvegicus	80-84
10689961-3	2000	It is also conceivable that 4 including a novel tetrasubstituted olefinic end group arises from epoxy carotenoids by the opening of the C-6-oxygen bond of the oxirane ring and the subsequent migration of the methyl group at the C-1 position (route b).	Oxygen	140-146	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	228-231
22205501-10	2013	Similar results were observed in SMCs exposed to hypoxia (1% oxygen) for 48 h. Ubiquitination assay showed that PTEN degradation occurs via proteasomal degradation pathway.	Oxygen	61-67	phosphatase and tensin homolog	Rattus norvegicus	112-116
23695836-17	2013	The ability of strain CAB to oxidize catechol via the oxygenase-dependent meta-cleavage pathway in the absence of external oxygen by using the biogenic oxygen produced from the dismutation of chlorite provides a valuable model for understanding the anaerobic degradation of a broad diversity of xenobiotics which are recalcitrant to anaerobic metabolism but labile to oxygenase-dependent mechanisms.	Oxygen	123-129	neural proliferation, differentiation and control 1	Homo sapiens	22-25
23572108-7	2013	RESULTS: Average corneal oxygen uptake rates at open eye during SCL wear for 10 subjects wearing 12 different commercial lenses vary from 2 to 10 muL(STP)/cm(2)/h.	Oxygen	25-31	thyroid hormone receptor interactor 10	Homo sapiens	150-153
10849663-16	2000	Using a mouse that lacks the gp91phox component of NADPH oxidase, we have recently shown that loss of the gp91phox-containing NADPH oxidase as a source of activated oxygen species does not impair HPV.	Oxygen	165-171	paired Ig-like receptor B	Mus musculus	29-33
23572108-8	2013	High oxygen permeability lenses have uptake rates of -10 muL(STP)/cm(2)/h, in close agreement with our previously obtained no-lens human uptake rates of 9 to 13 muL(STP)/cm(2)/h at open eye.	Oxygen	5-11	thyroid hormone receptor interactor 10	Homo sapiens	61-64
23572108-8	2013	High oxygen permeability lenses have uptake rates of -10 muL(STP)/cm(2)/h, in close agreement with our previously obtained no-lens human uptake rates of 9 to 13 muL(STP)/cm(2)/h at open eye.	Oxygen	5-11	thyroid hormone receptor interactor 10	Homo sapiens	165-168
23589166-7	2013	All of these iPS colonies that expanded under the various oxygen conditions stained positively for Oct3/4, Nanog, SSEA-4, and ALP.	Oxygen	58-64	Nanog homeobox	Homo sapiens	107-112
23589166-8	2013	However, Western blot analysis showed that the iPS cells cultured at 2.5% and 5% O2 expressed significantly more Nanog but less 53BP1 than those cultured at 20% O2 .	Oxygen	81-83	Nanog homeobox	Homo sapiens	113-118
11213471-10	2000	Northern blot analysis demonstrated that the expression of both xCT and 4F2hc was significantly enhanced by oxygen.	Oxygen	108-114	solute carrier family 7 member 11	Homo sapiens	64-67
24114546-5	2013	Retinal oxygen saturation for diabetic patients with no signs of diabetic retinopathy (NDR, n = 45) in arteries was 96.3 +- 8.6% (P = 0.662) and in veins, 58.7 +- 7.5% (P = 0.998).	Oxygen	8-14	serine/threonine kinase 38	Homo sapiens	87-90
24114546-10	2013	CONCLUSIONS: A trend of increasing retinal oxygen saturation was found from controls to NDR group to increasing levels of diabetic retinopathy, though significance was only reached for the comparison of controls to severe-NPDR, PDR, and all-DR groups.	Oxygen	43-49	serine/threonine kinase 38	Homo sapiens	88-91
23850731-1	2013	Genetic mutation in cytochrome c oxidase subunit III gene (MT-CO3) could influence the kinetics of cytochrome c oxidase (COX), which catalyzes oxygen transport capacity in oxidative phosphorylation.	Oxygen	143-149	COX3	Gallus gallus	20-52
23609983-0	2013	Catalytic phenol hydroxylation with dioxygen: extension of the tyrosinase mechanism beyond the protein matrix.	Oxygen	36-44	tyrosinase	Homo sapiens	63-73
23291190-6	2013	Regulation of SDH subunit expression by diverse epigenetic mechanisms implicates a crucial dosage-dependent role for SDH in oxygen homeostasis.	Oxygen	124-130	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	14-17
23291190-6	2013	Regulation of SDH subunit expression by diverse epigenetic mechanisms implicates a crucial dosage-dependent role for SDH in oxygen homeostasis.	Oxygen	124-130	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	117-120
23478801-12	2013	Mutation of Ngb at its oxygen-binding site (H64L) abolished the inhibitory effects of Ngb on Erk activation and HepG2 cell proliferation.	Oxygen	23-29	neuroglobin	Homo sapiens	12-15
23478801-12	2013	Mutation of Ngb at its oxygen-binding site (H64L) abolished the inhibitory effects of Ngb on Erk activation and HepG2 cell proliferation.	Oxygen	23-29	neuroglobin	Homo sapiens	86-89
23478801-13	2013	Therefore, we propose that Ngb controls HCC development by linking oxygen/ROS signals to oncogenic Raf/mitogen-activated protein kinase (MAPK)/Erk signaling.	Oxygen	67-73	neuroglobin	Homo sapiens	27-30
23642811-5	2013	Administration of a function-blocking EMMPRIN antibody (100 mug, twice per week for 4 weeks) to ApoE(-/-) mice, starting after 12 weeks of high-fat diet feeding caused attenuated and more stable atherosclerotic lesions, less reactive oxygen stress generation on plaque, as well as down-regulation of circulating interleukin-6 and monocyte chemotactic protein-1 in ApoE(-/-) mice.	Oxygen	234-240	basigin	Mus musculus	38-45
11213471-10	2000	Northern blot analysis demonstrated that the expression of both xCT and 4F2hc was significantly enhanced by oxygen.	Oxygen	108-114	solute carrier family 3 member 2	Homo sapiens	72-77
11213471-11	2000	The results suggest that oxygen regulates the activity of system xc- by modulating the expression of both xCT and 4F2hc mRNAs.	Oxygen	25-31	solute carrier family 7 member 11	Homo sapiens	106-109
11213471-11	2000	The results suggest that oxygen regulates the activity of system xc- by modulating the expression of both xCT and 4F2hc mRNAs.	Oxygen	25-31	solute carrier family 3 member 2	Homo sapiens	114-119
23454382-1	2013	As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing.	Oxygen	132-138	ubiquinol-cytochrome c reductase binding protein	Danio rerio	43-48
23641685-4	2013	Free radical reactions were initiated by pulsed laser photolysis (PLP) of Cl2 in the presence of HCHO and O2 in a flow reactor at 300-330 Torr and 295 K. IR-CRDS spectra were measured in mid-IR and near-IR regions over the ranges 3525-3700 cm(-1) (nu1) and 7250-7800 cm(-1) (A   X) respectively, at a delay time 100 mus after photolysis.	Oxygen	106-108	endogenous retrovirus group W member 5	Homo sapiens	74-77
11191053-6	2000	At low O2 tension, the stabilized and nuclear hypoxia inducible factor- 1alpha (HIF-1alpha) is directly phosphorylated by p42/p44 MAPKs, an action which enhances HIF-1-dependent transcriptional activition of VEGF.	Oxygen	7-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	46-78
23643711-4	2013	Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1alpha transcription and low content of phosphorylated CREB.	Oxygen	45-51	cAMP responsive element binding protein 1	Homo sapiens	194-198
23463031-1	2013	The stability of lithium salts, especially in the presence of reduced oxygen species, O2 and H2O (even in a small amount), plays an important role in the cyclability and capacity of Li-O2 cells.	Oxygen	70-76	immunoglobulin kappa variable 1D-39	Homo sapiens	86-96
23418090-6	2013	Levels of the oxygen-sensitive HIF-1alpha subunit and expression of HIF target genes were increased in both hypoxic cells and cells treated with ET-1.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	31-41
11191053-6	2000	At low O2 tension, the stabilized and nuclear hypoxia inducible factor- 1alpha (HIF-1alpha) is directly phosphorylated by p42/p44 MAPKs, an action which enhances HIF-1-dependent transcriptional activition of VEGF.	Oxygen	7-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	80-90
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	109-129
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	131-135
23916748-6	2013	This result supposed more fraction of the applied current is used for the electrocombustion reaction on Cell 2 if compared to Cell 1 and small amount rest for the side reaction of oxygen evolution.	Oxygen	180-186	carboxyl ester lipase pseudogene	Homo sapiens	104-110
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	185-195
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	80-86	keratin 10	Homo sapiens	687-701
23496802-7	2013	The calculated free energy profile at 300 K for the O2 addition to C13 confirms that the peroxidation on C13 is a reversible viable process in agreement with experiments.	Oxygen	52-54	homeobox C13	Homo sapiens	105-108
22278206-2	2013	This process generates oxygen-reactive species, ultimately responsible for a process known as oxidative stress, leading to changes in nitric oxide (NO), and cyclic guanosine monophosphate (cyclic GMP) signaling pathway.	Oxygen	23-29	5'-nucleotidase, cytosolic II	Homo sapiens	196-199
23727839-7	2013	Accordingly, the corresponding variant Rhodobacter sphaeroides ETF-QO proteins, when overexpressed in vitro, bind a CoQ10 pseudosubstrate, Q10Br, less tightly than the wild-type ETF-QO protein, suggesting that molecular oxygen can get access to the electrons in the misfolded ETF-QO protein, thereby generating superoxide and oxidative stress, which can be reversed by CoQ10 treatment.	Oxygen	220-226	electron transfer flavoprotein dehydrogenase	Homo sapiens	63-69
24672806-6	2013	PHD3 expression is also highly distinct from that of the other PHD enzymes, and varies considerably between different cell types and oxygen concentrations.	Oxygen	133-139	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
23643178-8	2013	RESULTS: The expression of hypoxia inducible factor-1alpha was induced and up-regulated when BMSCs were grown under 1% oxygen.	Oxygen	119-125	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	27-58
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	80-86	keratin 10	Homo sapiens	816-830
23900098-2	2013	The physiological roles of NGB may include transportation of oxygen, protection against ischemia/hypoxia injury and oxidative stress, function as a redox-coupled sensor regulating the G-protein coupled transduction pathway, protection against neuronal apoptosis, and working as a terminal oxidase.	Oxygen	61-67	neuroglobin	Homo sapiens	27-30
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	80-86	keratin 10	Homo sapiens	816-830
24228453-5	2013	Since a decrease in pulmonary artery pressure could induce coronary steal phenomenon, we ventilated the patient with minimally required FI(O2) to maintain Sp(O2) 98-100%, and maintained Pa(CO2) between 40 and 50 mmHg to avoid myocardial ischemia before the induction of cardiopulmonary bypass (CPB).	Oxygen	139-141	immunoglobulin kappa variable 1D-39	Homo sapiens	155-160
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	200-206	keratin 10	Homo sapiens	687-701
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	200-206	keratin 10	Homo sapiens	816-830
23402364-4	2013	In contrast, reddish-orange compound(s) characteristic of o-quinone- and nitroso-VP-16 were readily generated in a hydrophobic medium (chloroform) in an oxygen-dependent manner.	Oxygen	153-159	host cell factor C1	Homo sapiens	81-86
15256935-3	2000	Stimulation of fibroblast and endothelial cell proliferation through Hyperbaric oxygenation has been demonstrated in numerous studies.The aim of this study was to investigate the effect of hyperbaric oxygen treatment on the proliferation and differentiation of human keratinocyte cultures.The influence of hyperbaric oxygenation on the proliferation of human keratinocyte cultures was demonstrated using flow-through cytometry and a fluorescence activated cell sorter, which detects fluorescence intensity following incorporation of 5-bromo-2"-deoxyuridine in cell DNA.The degree of cell differentiation was deduced from the expression of various components of the cytoskeleton, such as cytokeratin 10 and involukrin, the production of which was quantified through the determination of monoclonal antibodies against cytokeratin 10 and involukrin from measurements of fluorescence activity in a flow-through cytometer.Hyperbaric oxygenation of cell cultures in vitro did not produce a significantly higher rate of cell proliferation, so that no increase in vitality was observed.An interesting observation following exposure to hyperbaric oxygen was the marked increase in expression of both cytokeratin 10 and involukrin, as an indication of accelerated cell differentiation.	Oxygen	200-206	keratin 10	Homo sapiens	816-830
23402364-5	2013	Similar products were also formed when the VP-16 radical, generated from VP-16 and horseradish peroxidase/H2O2, was exposed directly to ( )NO in chloroform in the presence of oxygen.	Oxygen	175-181	host cell factor C1	Homo sapiens	43-48
23402364-5	2013	Similar products were also formed when the VP-16 radical, generated from VP-16 and horseradish peroxidase/H2O2, was exposed directly to ( )NO in chloroform in the presence of oxygen.	Oxygen	175-181	host cell factor C1	Homo sapiens	73-78
23487766-2	2013	AOX is a diiron carboxylate protein that catalyzes the four-electron reduction of dioxygen to water by ubiquinol.	Oxygen	82-90	acyl-CoA oxidase 1	Homo sapiens	0-3
23969990-0	2013	Effects of stromal cell derived factor-1 and CXCR4 on the promotion of neovascularization by hyperbaric oxygen treatment in skin flaps.	Oxygen	104-110	C-X-C motif chemokine receptor 4	Rattus norvegicus	45-50
24069415-0	2013	c-Src and neural Wiskott-Aldrich syndrome protein (N-WASP) promote low oxygen-induced accelerated brain invasion by gliomas.	Oxygen	71-77	WASP like actin nucleation promoting factor	Homo sapiens	10-49
24069415-0	2013	c-Src and neural Wiskott-Aldrich syndrome protein (N-WASP) promote low oxygen-induced accelerated brain invasion by gliomas.	Oxygen	71-77	WASP like actin nucleation promoting factor	Homo sapiens	51-57
10667518-8	2000	Myoglobin oxygen saturation increased and both cytochromes became more oxidized in the presence of propofol.	Oxygen	10-16	myoglobin	Cavia porcellus	0-9
24069415-7	2013	Downregulating c-Src or NWASP by RNA interference abrogates the low-oxygen-induced enhancement in motility by in vitro assays and in organotypic brain slice cultures.	Oxygen	68-74	WASP like actin nucleation promoting factor	Homo sapiens	24-29
24069415-8	2013	The findings support the idea that c-Src and NWASP play key roles in mediating the molecular pathogenesis of low oxygen-induced accelerated brain invasion by gliomas.	Oxygen	113-119	WASP like actin nucleation promoting factor	Homo sapiens	45-50
24040106-0	2013	SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.	Oxygen	114-120	putative glucosidase SIM1	Saccharomyces cerevisiae S288C	37-42
24040106-3	2013	Here we show that three of the four Saccharomyces cerevisiae SUN family proteins, Uth1p, Sim1p and Sun4p, are efficiently secreted out of the cells in different growth phases and their production is affected by the level of oxygen.	Oxygen	224-230	putative glucosidase SIM1	Saccharomyces cerevisiae S288C	89-94
23341197-4	2013	Exposure of primary isolated trophoblasts to 3% O(2) resulted in elevated Par6 expression, maintenance of tight junction marker ZO-1 at cell boundaries, and decreased fusogenic syncytin 1 expression compared with cells cultured at 20% O(2).	Oxygen	48-52	par-6 family cell polarity regulator alpha	Homo sapiens	74-78
10662897-11	2000	Thus, restriction of nutrient and oxygen supply throughout fetal life was associated with suppression of renal renin and renal angiotensinogen gene expression, with no effect on hepatic angiotensinogen mRNA levels.	Oxygen	34-40	angiotensinogen	Ovis aries	127-142
23059865-6	2013	In STG, V O2max increased (P &lt; 0.01) from 32.6 +- 4.9 to 35.4 +- 6.6 mL min-1 kg-1 and relative V O2 during cycling at 100 W was lowered (P &lt; 0.05) from 55% +- 7% to 50% +- 8% V O2max over 6 months, with no changes in DAG.	Oxygen	10-12	chromosome 6 open reading frame 15	Homo sapiens	3-6
23449493-7	2013	For severe SDB, the event frequency (AI, AHI4%, and RDI) was lower and O2 desaturation was improved on CPAP withdrawal.	Oxygen	71-73	centromere protein J	Homo sapiens	103-107
23449493-10	2013	CONCLUSIONS: Over a wide range of SDB severity CPAP withdrawal results in recurrence of SDB, albeit with less severe O2 desaturation.	Oxygen	117-119	centromere protein J	Homo sapiens	47-51
23883551-0	2013	Oxygen adsorption on the Al9Co2(001) surface: first-principles and STM study.	Oxygen	0-6	sulfotransferase family 1A member 3	Homo sapiens	67-70
23883551-1	2013	Atomic oxygen adsorption on a pure aluminum terminated Al9Co2(001) surface is studied by first-principle calculations coupled with STM measurements.	Oxygen	7-13	sulfotransferase family 1A member 3	Homo sapiens	131-134
10613739-2	2000	Hepatic stellate cells are oxygen-sensing cells, capable of producing VEGF.	Oxygen	27-33	vascular endothelial growth factor A	Rattus norvegicus	70-74
23871826-7	2013	Also, oxygen stress induced S-phase arrest of cancer cells by way of regulating expression of DNA Topo I, p53, CDK2 and Cyclin A and caused DNA damage.	Oxygen	6-12	cyclin dependent kinase 2	Rattus norvegicus	111-115
23201463-1	2013	Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs.	Oxygen	168-174	hemoglobin subunit gamma 2	Homo sapiens	75-88
23201463-1	2013	Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs.	Oxygen	168-174	hemoglobin subunit gamma 2	Homo sapiens	90-95
23201463-1	2013	Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs.	Oxygen	176-181	hemoglobin subunit gamma 2	Homo sapiens	75-88
10587525-3	1999	Reduced tissue oxygen tension triggers VEGF expression, and increased protein and mRNA levels for VEGF and its receptors (Flt-1, Flk-1/KDR) occur in the ischemic rat brain.	Oxygen	15-21	vascular endothelial growth factor A	Rattus norvegicus	39-43
23201463-1	2013	Methemoglobinemia is a disease that results from abnormally high levels of methemoglobin (MetHb) in the red blood cell (RBC), which is caused by simultaneous uptake of oxygen (O(2)) and nitric oxide (NO) in the human lungs.	Oxygen	176-181	hemoglobin subunit gamma 2	Homo sapiens	90-95
23201463-2	2013	MetHb is produced in the RBC by irreversible NO-induced oxidation of the oxygen carrying ferrous ion (Fe(2+)) present in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe(3+)).	Oxygen	73-79	hemoglobin subunit gamma 2	Homo sapiens	0-5
23794249-9	2013	Finally, GCM1 mRNA expression increased during trophoblast differentiation at 21% O2 , but was inhibited at 2.5% O2 .	Oxygen	82-84	glial cells missing transcription factor 1	Homo sapiens	9-13
23794249-9	2013	Finally, GCM1 mRNA expression increased during trophoblast differentiation at 21% O2 , but was inhibited at 2.5% O2 .	Oxygen	113-115	glial cells missing transcription factor 1	Homo sapiens	9-13
23287475-10	2013	This reprogramming appears to be accomplished stepwise, with the assembly of the triad into a sophisticated transcriptional, oxygen-dependent circuitry, in which Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation.	Oxygen	125-131	Nanog homeobox	Homo sapiens	162-167
23287475-10	2013	This reprogramming appears to be accomplished stepwise, with the assembly of the triad into a sophisticated transcriptional, oxygen-dependent circuitry, in which Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation.	Oxygen	125-131	Kruppel like factor 4	Homo sapiens	172-176
23748219-6	2013	On the other hand, at low oxygen concentrations ([O2] = 40-50 muM), nNOS performs a net two-electron reduction of quinones and nitroaromatics.	Oxygen	26-32	nitric oxide synthase 1	Rattus norvegicus	68-72
23805000-5	2013	Caenorhabditis elegans that lack the EGL-9 oxygen sensing enzyme have been shown to be resistant to hydrogen cyanide (HCN) gas produced by the pathogen Pseudomonas aeruginosa PAO1.	Oxygen	43-49	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	37-42
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Oxygen	130-136	aconitase 1	Mus musculus	242-246
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Oxygen	130-136	iron responsive element binding protein 2	Mus musculus	251-255
23748219-6	2013	On the other hand, at low oxygen concentrations ([O2] = 40-50 muM), nNOS performs a net two-electron reduction of quinones and nitroaromatics.	Oxygen	50-52	nitric oxide synthase 1	Rattus norvegicus	68-72
10590028-0	1999	Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice.	Oxygen	30-36	surfactant associated protein B	Mus musculus	0-20
10590028-3	1999	Heterozygous SP-B (+/-)-deficient mice have 50% less SP-B protein, proprotein, and SP-B mRNA compared with control mice and are highly susceptible to oxygen-induced lung injury.	Oxygen	150-156	surfactant associated protein B	Mus musculus	13-17
23065129-8	2013	Furthermore, the oxygen sensor hypoxia-inducible factor (HIF)-1/2alpha and the angiogenic factor vascular endothelial growth factor (VEGF) were highly expressed in the lungs of sildenafil-treated rats.	Oxygen	17-23	endothelial PAS domain protein 1	Rattus norvegicus	31-70
23811225-2	2013	Key aspects of ischemia-reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2-ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2-sensing HIF (hypoxia-inducible factor) hydroxylase EGL-9.	Oxygen	93-95	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	233-238
23811225-2	2013	Key aspects of ischemia-reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2-ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2-sensing HIF (hypoxia-inducible factor) hydroxylase EGL-9.	Oxygen	179-181	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	233-238
10590028-5	1999	After exposure to 95% oxygen for 3 d, opening pressures were increased and maximal lung volumes were significantly decreased in SP-B (+/-) mice compared with SP-B (+/+) mice.	Oxygen	22-28	surfactant associated protein B	Mus musculus	128-132
23811225-3	2013	From a genetic screen, we found that the cytochrome P450 oxygenase CYP-13A12 acts in response to the EGL-9-HIF-1 pathway to facilitate the O2-ON response.	Oxygen	139-141	CYtochrome P450 family	Caenorhabditis elegans	67-76
23811225-3	2013	From a genetic screen, we found that the cytochrome P450 oxygenase CYP-13A12 acts in response to the EGL-9-HIF-1 pathway to facilitate the O2-ON response.	Oxygen	139-141	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	101-106
10590028-7	1999	SP-B-treated SP-B (+/-) mice survived longer in 95% oxygen.	Oxygen	52-58	surfactant associated protein B	Mus musculus	0-4
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	Oxygen	78-84	glutathione S-transferase theta 1	Homo sapiens	131-136
10590028-7	1999	SP-B-treated SP-B (+/-) mice survived longer in 95% oxygen.	Oxygen	52-58	surfactant associated protein B	Mus musculus	13-17
24455718-4	2013	Here, we demonstrated via antibody blocking experiments that alphaV beta5 and alpha 6 significantly promoted hESC attachment in 2% O2 only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone.	Oxygen	198-200	CD44 molecule (Indian blood group)	Homo sapiens	160-164
10590028-9	1999	Abnormalities in pulmonary function in SP-B (+/-) mice after oxygen exposure were associated with increased alveolar capillary leak, which was corrected by administration of SP-B with DPPC and POPG.	Oxygen	61-67	surfactant associated protein B	Mus musculus	39-43
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	76-78	CD44 molecule (Indian blood group)	Homo sapiens	60-64
10590028-9	1999	Abnormalities in pulmonary function in SP-B (+/-) mice after oxygen exposure were associated with increased alveolar capillary leak, which was corrected by administration of SP-B with DPPC and POPG.	Oxygen	61-67	surfactant associated protein B	Mus musculus	174-178
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	CD44 molecule (Indian blood group)	Homo sapiens	60-64
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	CD44 molecule (Indian blood group)	Homo sapiens	60-64
23550806-8	2013	Treatment with BDNF or dbcAMP decreased EtOH or EtOH-activated microglial conditioned medium-induced changes in the levels of intracellular free radicals, ROS and O2-, nitrite, GSH, and catalase.	Oxygen	163-165	brain-derived neurotrophic factor	Rattus norvegicus	15-19
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	CD44 molecule (Indian blood group)	Homo sapiens	60-64
10590028-10	1999	Likewise, histologic abnormalities caused by oxygen-induced lung injury were improved by administration of SP-B with DPPC and POPG.	Oxygen	45-51	surfactant associated protein B	Mus musculus	107-111
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	CD44 molecule (Indian blood group)	Homo sapiens	60-64
24455718-5	2013	Immunofluorescence confirmed expression of alphaV beta5 and CD44 in both 2% O2 and 21% O2 cultured hESCs while flow cytometry revealed significantly higher alphaV beta5 expression in 2% O2 versus 21% O2 cultured hESCs and higher CD44 expression in 21% O2 versus 2% O2 cultured hESCs.	Oxygen	87-89	CD44 molecule (Indian blood group)	Homo sapiens	60-64
24455718-6	2013	Adhered hESCs following blockage of alphaV beta5 in 2% O2 displayed a reduction in nuclear colocalisation of Oct-4 and Nanog with little effect observed in 21% O2.	Oxygen	55-57	Nanog homeobox	Homo sapiens	119-124
24455718-7	2013	Blockage of CD44 had the converse effect with dramatic reductions in nuclear colocalisation of Oct-4 and Nanog in 21% O2 cultured hESC which retained adherence, but not in 2% O2 cultured cells.	Oxygen	118-120	CD44 molecule (Indian blood group)	Homo sapiens	12-16
24455718-7	2013	Blockage of CD44 had the converse effect with dramatic reductions in nuclear colocalisation of Oct-4 and Nanog in 21% O2 cultured hESC which retained adherence, but not in 2% O2 cultured cells.	Oxygen	118-120	Nanog homeobox	Homo sapiens	105-110
23690557-1	2013	Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes (PHD1, 2 and 3) regulates a range of transcriptional responses to hypoxia.	Oxygen	0-6	egl-9 family hypoxia-inducible factor 2	Mus musculus	135-148
23434931-6	2013	Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).	Oxygen	11-17	PDR	Homo sapiens	56-59
23434931-6	2013	Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	83-88
23434931-6	2013	Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).	Oxygen	11-17	vascular endothelial growth factor A	Mus musculus	165-170
10565290-0	1999	Myoglobin-containing carbon-paste enzyme microelectrodes for the biosensing of glucose under oxygen-deficit conditions.	Oxygen	93-99	myoglobin	Homo sapiens	0-9
23686836-5	2013	CXCR4 expression, analyzed by real-time PCR and Western blot, was increased in human chondrosarcoma cell line JJ compared with normal chondrocytes and was further increased in JJ by hypoxia (2% O2), vascular endothelial growth factor A (VEGFA; 10 ng/mL), and in xenograft tumors in nude mice.	Oxygen	194-196	C-X-C motif chemokine receptor 4	Homo sapiens	0-5
23085290-1	2013	This paper presents an integrated model of convective O(2)-transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals (Leptonychotes weddellii).	Oxygen	125-131	myoglobin	Leptonychotes weddellii	150-159
23085290-1	2013	This paper presents an integrated model of convective O(2)-transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals (Leptonychotes weddellii).	Oxygen	125-131	myoglobin	Leptonychotes weddellii	161-163
23085290-4	2013	We also find that the cardiac system, the muscle O(2)-store, animal behavior (i.e. pre-dive ventilation), and the oxygen binding affinity of Mb, K(O(2)), have co-evolved to optimize dive duration at routine aerobic diving conditions, suggesting that such conditions are mostly selected upon in seals.	Oxygen	114-120	myoglobin	Leptonychotes weddellii	141-143
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	33-39	myoglobin	Homo sapiens	47-56
24175472-3	2013	They consist, from one side, in activating of the constitutive de novo biosynthesis of nitric oxide by cNOS, from other side, in suppression of inducible nitric oxide de novo synthesis by iNOS in such way to prevent the formation of toxic peroxynitrite by co-operation of surplus nitric oxide with superoxide anion, thereby limits the generation of toxic active forms of nitrogen (*NO2) and oxygen (*OH).	Oxygen	391-397	nitric oxide synthase 3	Canis lupus familiaris	103-107
23545291-2	2013	To increase the cooling rate and reduce the CPA concentration required for vitrification, this study proposed an innovative approach, named forced-convective vitrification with liquid cryogens, in which liquid oxygen at a temperature below its boiling point (LOX(bbp)) was used as the cryogen to reduce the generation of insulating bubbles of gaseous oxygen and the sample was subjected to a constant velocity to remove insulation bubbles from the sample.	Oxygen	210-216	lysyl oxidase	Homo sapiens	259-262
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	123-129	myoglobin	Homo sapiens	47-56
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	123-129	myoglobin	Homo sapiens	47-56
23646803-5	2013	The Sn3d5-binding strength of the SnO2+x thin film that was annealed in oxygen atmosphere was weaker than that of the SnO2 thin film.	Oxygen	72-78	strawberry notch homolog 2	Homo sapiens	34-37
10565290-3	1999	Such use of myoglobin-containing mineral oil thus offers an attractive alternative to the use of oxygen-rich fluorocarbon pasting liquids.	Oxygen	97-103	myoglobin	Homo sapiens	12-21
23349477-3	2013	PXR ablation inhibited high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance, which were accounted for by increased oxygen consumption, increased mitochondrial beta-oxidation, inhibition of hepatic lipogenesis and inflammation, and sensitization of insulin signaling.	Oxygen	141-147	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
23349477-5	2013	The ob/ob mice deficient of PXR showed increased oxygen consumption and energy expenditure, as well as inhibition of gluconeogenesis and increased rate of glucose disposal during euglycemic clamp.	Oxygen	49-55	nuclear receptor subfamily 1, group I, member 2	Mus musculus	28-31
10565290-5	1999	Factors affecting the oxygen independence of the new enzyme microelectrodes, including the myoglobin loading or length of the oxygen reservoir, have been optimized.	Oxygen	22-28	myoglobin	Homo sapiens	91-100
24195687-4	2013	Complete epitaxial AlP-InP nanowire structures were first grown in an oxygen-free environment.	Oxygen	70-76	ATHS	Homo sapiens	19-22
10565290-6	1999	The myoglobin-doped mineral oil or Kel-F-based carbon-paste enzyme microelectrodes display a highly stable glucose response over prolonged (6-7 h) operations in oxygen-free solutions, indicating no depletion of the internal oxygen supply.	Oxygen	161-167	myoglobin	Homo sapiens	4-13
10565290-6	1999	The myoglobin-doped mineral oil or Kel-F-based carbon-paste enzyme microelectrodes display a highly stable glucose response over prolonged (6-7 h) operations in oxygen-free solutions, indicating no depletion of the internal oxygen supply.	Oxygen	224-230	myoglobin	Homo sapiens	4-13
11212295-3	1999	In yeast, oxygen sensing and heme signaling are primarily mediated by the heme activator protein Hap1, which, in response to heme, activates the transcription of genes required for respiration and for controlling oxidative damage.	Oxygen	10-16	Hap1p	Saccharomyces cerevisiae S288C	97-101
23595061-9	2013	CPAP-F infants had a prolonged need for respiratory support and oxygen therapy, and a higher risk of death or bronchopulmonary dysplasia at 25-28 weeks" gestation (CPAP-F 53% vs. CPAP-S 14%, relative risk 3.8, 95% CI 1.6, 9.3) and a substantially higher risk of pneumothorax at 29-32 weeks.	Oxygen	64-70	centromere protein J	Homo sapiens	0-4
30337774-0	2013	Filterless optical oxygen sensor based on a CMOS buried double junction photodiode.	Oxygen	19-25	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	44-48
23534609-6	2013	BMSCs protected against neonatal rat hyperoxic lung injury during recovery as demonstrated by enhanced expression of AQP5 and SP-C, likely due to the suppression of alveolar cell apoptosis and lung inflammation responses to oxygen with up-regulation of the expression of BCL-2 gene and down-regulation of the expression of BAX gene and stimulation of vascular endothelial growth factor and so on.	Oxygen	224-230	aquaporin 5	Rattus norvegicus	117-121
23506274-5	2013	Under 20% oxygen, but not 1.5% or 5%, NGF decreased apoptosis in mouse ovaries by down-regulating the pro-apoptotic genes Bax and p53.	Oxygen	10-16	nerve growth factor	Mus musculus	38-41
23506274-5	2013	Under 20% oxygen, but not 1.5% or 5%, NGF decreased apoptosis in mouse ovaries by down-regulating the pro-apoptotic genes Bax and p53.	Oxygen	10-16	BCL2-associated X protein	Mus musculus	122-125
23506274-6	2013	In conclusion, high oxygen tension during in vitro ovarian culture promotes follicle growth and, in conjunction with NGF, suppresses apoptosis.	Oxygen	20-26	nerve growth factor	Mus musculus	117-120
23584901-4	2013	Notably, together with ERRgamma, expression of KLK1, KCNQ1, KCNE1, KCNE3, and KCNE5 was markedly reduced when cells were cultured in a hypoxic environment (2% O2).	Oxygen	159-161	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	60-65
23584901-4	2013	Notably, together with ERRgamma, expression of KLK1, KCNQ1, KCNE1, KCNE3, and KCNE5 was markedly reduced when cells were cultured in a hypoxic environment (2% O2).	Oxygen	159-161	potassium voltage-gated channel subfamily E regulatory subunit 5	Homo sapiens	78-83
23524851-2	2013	Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the unfolded protein response (UPR) kinase PERK and the lysosomal enzyme cathepsin B.	Oxygen	82-88	SUMO specific peptidase 3	Homo sapiens	57-62
23662474-6	2013	Soluble betaAP induces mitochondrial dysfunction, increased production of reactive oxygen species in neurons, disorganization of cell plasma membranes, disturbances of ion transport across cell membranes, impairment of synaptic transmission and long-term synaptic plasticity, etc.	Oxygen	83-89	serpin family F member 2	Homo sapiens	8-14
23524851-2	2013	Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the unfolded protein response (UPR) kinase PERK and the lysosomal enzyme cathepsin B.	Oxygen	82-88	cathepsin B	Homo sapiens	245-256
10393927-0	1999	O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.	Oxygen	0-2	paired Ig-like receptor B	Mus musculus	44-48
23671091-2	2013	The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.	Oxygen	106-112	stearoyl-CoA desaturase	Homo sapiens	155-160
23095889-9	2012	We also show that, concurrently, HIF1alpha maintains cellular levels of oxygen, most likely by controlling the expression of pyruvate dehydrogenase kinase 1, an inhibitor of the tricarboxylic acid cycle.	Oxygen	72-78	pyruvate dehydrogenase kinase 1	Homo sapiens	125-156
23204802-1	2012	PURPOSE: We investigated whether oxygen-induced retinopathy (OIR) results in changes in the protein expression of neuronal and inducible nitric oxide synthases (nNOS and iNOS, respectively) in rat model of OIR.	Oxygen	33-39	nitric oxide synthase 1	Rattus norvegicus	161-165
23663141-6	2013	The reaction between reduced GOx and Ru(NH3)6(3+) is rapid even in air-saturated Tris buffer, where the faster competitive reaction between reduced GOx and dissolved oxygen also occurs.	Oxygen	166-172	hydroxyacid oxidase 1	Homo sapiens	29-32
10393927-10	1999	Deletion of gp91 phox did not alter p22 phox expression but severely inhibited activated O2 species production.	Oxygen	89-91	paired Ig-like receptor B	Mus musculus	12-16
23663141-6	2013	The reaction between reduced GOx and Ru(NH3)6(3+) is rapid even in air-saturated Tris buffer, where the faster competitive reaction between reduced GOx and dissolved oxygen also occurs.	Oxygen	166-172	hydroxyacid oxidase 1	Homo sapiens	148-151
23695836-9	2013	Further, under anoxic growth conditions strain CAB utilized the biogenic oxygen produced as a result of chlorite dismutation to oxidize catechol via the meta-cleavage pathway of aerobic catechol degradation and the catechol 2,3-dioxygenase enzyme.	Oxygen	73-79	neural proliferation, differentiation and control 1	Homo sapiens	47-50
23113750-0	2012	Spin accommodation and reactivity of silver clusters with oxygen: the enhanced stability of Ag13(-).	Oxygen	58-64	spindlin 1	Homo sapiens	0-4
10360941-8	1999	The other carboxylate oxygen of the inhibitor interacts with Pro-1.	Oxygen	22-28	proline dehydrogenase	Mus musculus	61-66
23113750-1	2012	Spin accommodation is demonstrated to play a determining role in the reactivity of silver cluster anions with oxygen.	Oxygen	110-116	spindlin 1	Homo sapiens	0-4
26605629-5	2012	The translational and rotational motions of the protein-bound spin label are considerably slowed compared to those of the free spin label in aqueous solution, but interestingly, hydrogen bonds formed between the nitroxide oxygen group and the surrounding water molecules are hardly affected by the presence of the amyloid protein.	Oxygen	222-228	spindlin 1	Homo sapiens	62-66
26605629-5	2012	The translational and rotational motions of the protein-bound spin label are considerably slowed compared to those of the free spin label in aqueous solution, but interestingly, hydrogen bonds formed between the nitroxide oxygen group and the surrounding water molecules are hardly affected by the presence of the amyloid protein.	Oxygen	222-228	spindlin 1	Homo sapiens	127-131
23695836-17	2013	The ability of strain CAB to oxidize catechol via the oxygenase-dependent meta-cleavage pathway in the absence of external oxygen by using the biogenic oxygen produced from the dismutation of chlorite provides a valuable model for understanding the anaerobic degradation of a broad diversity of xenobiotics which are recalcitrant to anaerobic metabolism but labile to oxygenase-dependent mechanisms.	Oxygen	54-60	neural proliferation, differentiation and control 1	Homo sapiens	22-25
23468167-4	2013	Upon white light irradiation, the PIOT-HA NPs can sensitize oxygen to generate reactive oxygen species (ROS) that inactivate the neighboring CD44 protein, which inhibits the migration of MDA-MB-231 cancer cells.	Oxygen	60-66	CD44 molecule (Indian blood group)	Homo sapiens	141-145
23671606-4	2013	Moreover, hESCs cultured at atmospheric O2 levels expressed significantly less OCT4, SOX2 and NANOG than those maintained at 5% O2.	Oxygen	40-42	SRY-box transcription factor 2	Homo sapiens	85-89
23671606-4	2013	Moreover, hESCs cultured at atmospheric O2 levels expressed significantly less OCT4, SOX2 and NANOG than those maintained at 5% O2.	Oxygen	40-42	Nanog homeobox	Homo sapiens	94-99
10329706-2	1999	Previously, we found that oxygen deprivation induced tissue factor, especially in mononuclear phagocytes, by an early growth response (Egr-1)-dependent pathway without involvement of HIF-1 (Yan, S.-F., Zou, Y.-S., Gao, Y., Zhai, C., Mackman, N., Lee, S., Milbrandt, J., Pinsky, D., Kisiel, W., and Stern, D. (1998) Proc.	Oxygen	26-32	early growth response 1	Homo sapiens	135-140
23671606-8	2013	GLUT1 expression correlated with glucose consumption and using siRNA and chromatin immunoprecipitation was found to be directly regulated by hypoxia inducible factor (HIF)-2alpha at 5% O2.	Oxygen	185-187	solute carrier family 2 member 1	Homo sapiens	0-5
23668766-5	2013	The phase II time constant for VO2p (tauVO2p) was reduced in Mod 2 (22 s (Mod 1), 19 s (Mod 2); p &lt; 0.05), as was the "overshoot" in the normalized [HHb]/O2 uptake ratio (p &lt; 0.05).	Oxygen	32-34	chromobox 1	Homo sapiens	74-79
23644619-7	2013	RAGE expression, TNF-alpha, and IL-6 were downregulated by controlled oxygen treatment (p &lt; 0.001).	Oxygen	70-76	interleukin 6	Canis lupus familiaris	32-36
22633700-8	2012	In addition, MMP-9 levels were correlated with age, troponin level, and oxygen saturation.	Oxygen	72-78	matrix metallopeptidase 9	Homo sapiens	13-18
23267891-3	2012	hERO1-L alpha is expressed within normoxic cells at very low levels, but may be induced in hypoxic cells such as tumor cells in response to low oxygen availability.	Oxygen	144-150	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	0-13
22714395-12	2012	We propose that HBB, along with other genes involved in oxygen metabolism, confers a more aggressive metastatic phenotype in BrCa cells disseminated to bone.	Oxygen	56-62	BRCA1 DNA repair associated	Homo sapiens	125-129
23421720-9	2013	On the other hand, circadian transgenic zebrafish cells, simulating a repressed or an overstimulated circadian clock, modified gene transcription levels of oxygen-regulated genes such as erythropoietin and vascular endothelial growth factor 165 and altered the hypoxia-induced increase in Hif-1alpha protein concentration.	Oxygen	156-162	erythropoietin a	Danio rerio	187-201
10320680-10	1999	Oxygen consumption studies in the presence of FeSO4 showed that the antioxidant effect of DIP or RA-25 did not involved the initial step of Fe2+ oxidation.	Oxygen	0-6	RA25	Homo sapiens	97-102
23613849-5	2013	Moreover, the expression of two stem cell marker genes, Nanog and Oct-4, was upregulated in the cells cultured in 5% O2.	Oxygen	117-119	Nanog homeobox	Homo sapiens	56-61
23613849-6	2013	Finally, in cultures under 5% O2, more hTSCs expressed the stem cell markers nucleostemin, Oct-4, Nanog and SSEA-4.	Oxygen	30-32	Nanog homeobox	Homo sapiens	98-103
22956520-6	2012	High O(2)-cultured oocytes also showed higher amounts of SOD1, SOD2, GSR, GPX1, and CAT mRNA.	Oxygen	5-9	superoxide dismutase 2	Canis lupus familiaris	63-67
22948140-0	2012	Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.	Oxygen	198-204	pyruvate dehydrogenase kinase 1	Homo sapiens	18-49
10463102-3	1999	These cells responded to fMLP or PAF (1 microM each) with an increase in [Ca2+]i (217.3 +/- 22.1 and 197.8 +/- 22.1 nM respectively) which was associated with production of O2- (40.2 +/- 8.2 and 35.2 +/- 7.6 pmol/min/10(6) cells respectively).	Oxygen	173-175	PCNA clamp associated factor	Homo sapiens	33-36
22998407-2	2012	The conversion of water to dioxygen in photosynthesis illustrates one example, in which a redox-inactive Ca(II) ion and four manganese ions are required for function.	Oxygen	27-35	carbonic anhydrase 2	Homo sapiens	105-111
26282035-0	2013	Aberration-Corrected TEM Imaging of Oxygen Occupancy in YSZ.	Oxygen	36-42	MFT2	Homo sapiens	21-24
26282035-2	2013	Also, individual contributions both from oxygen column occupancy and the static displacement of oxygen atoms due to occupancy change to the observed column intensities of TEM images were systematically investigated using HRTEM simulation.	Oxygen	96-102	MFT2	Homo sapiens	171-174
26282035-4	2013	Utilizing the aberration-corrected TEM capability and HRTEM simulation results, we experimentally verified that oxygen vacancies segregate near the single grain boundary of a YSZ bicrystal.	Oxygen	112-118	MFT2	Homo sapiens	35-38
10463102-5	1999	Removal or chelation of extracellular Ca2+ induced a reduction of both the fMLP and PAF-induced [Ca2+]i rise and O2- production.	Oxygen	113-115	PCNA clamp associated factor	Homo sapiens	84-87
23100432-6	2012	We report that microglial IRAK4 is necessary in vitro for fAbeta to activate the canonical pro-inflammatory signaling pathways leading to activation of p38, JNK, and ERK MAP kinases and to generate reactive oxygen species.	Oxygen	207-213	interleukin-1 receptor-associated kinase 4	Mus musculus	26-31
10463102-8	1999	Furthermore, Ni2+ exhibited an inhibition of both fMLP and PAF-induced [Ca2+]i rise and O2- production.	Oxygen	88-90	PCNA clamp associated factor	Homo sapiens	59-62
10463102-10	1999	Our results indicate that fMLP and PAF dependent O2- production in human eosinophils require intra- and extracellular Ca2+ and that Ca2+ influx is necessary for optimal activation.	Oxygen	49-51	PCNA clamp associated factor	Homo sapiens	35-38
23392406-3	2013	Sulfite biosensors are based on measurement of either O2 or electrons generated from splitting of H2O2 or heat released during oxidation of sulfite by immobilized sulfite oxidase.	Oxygen	54-56	sulfite oxidase	Homo sapiens	163-178
10226046-3	1999	Copper, nonheme and heme iron coordination complexes have been used to mimic reversible dioxygen-binding by the three classes of blood-oxygen carriers - hemocyanin, hemerythrin and hemoglobin/myoglobin - while functional mimics of oxygenases and oxidases with copper and iron have also provided key insights into important dioxygen activation processes.	Oxygen	90-96	myoglobin	Homo sapiens	192-201
23380539-0	2013	The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.	Oxygen	47-53	egl-9 family hypoxia inducible factor 3	Homo sapiens	81-85
23380539-4	2013	PHD3 shows a different expression pattern and subcellular localization as well as activity under low oxygen tension.	Oxygen	101-107	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
22885163-1	2012	During investigations of the phenotypic diversity of hemoglobin (Hb) E beta thalassemia, a patient was encountered with persistently high levels of methemoglobin associated with a left-shift in the oxygen dissociation curve, profound ascorbate deficiency, and clinical features of scurvy; these abnormalities were corrected by treatment with vitamin C.	Oxygen	198-204	hemoglobin subunit gamma 2	Homo sapiens	148-161
22874974-0	2012	Significant effect of spin flip on the oxygen atom transfer reaction from (oxo)manganese(V) corroles to thioanisole: insights from density functional calculations.	Oxygen	39-45	spindlin 1	Homo sapiens	22-26
22874974-1	2012	The electronic and structural features of (oxo)manganese(V) corroles and their catalyzed oxygen atom transfers to thioanisole in different spin states have been investigated by the B3LYP functional calculations.	Oxygen	89-95	spindlin 1	Homo sapiens	139-143
23830406-3	2013	In the thick ascending limb (TAL) ADH increases transport via cAMP, while Ang II acts via superoxide (O2-).	Oxygen	102-104	angiogenin	Rattus norvegicus	74-77
10202154-1	1999	Hypoxia-inducible factor 1 alpha (HIF1alpha) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen.	Oxygen	156-162	HLF transcription factor, PAR bZIP family member	Homo sapiens	69-72
23453623-4	2013	Loss of FBP1 also inhibits oxygen consumption and reactive oxygen species production by suppressing mitochondrial complex I activity; this metabolic reprogramming results in an increased CSC-like property and tumorigenicity by enhancing the interaction of beta-catenin with T-cell factor.	Oxygen	27-33	fructose-bisphosphatase 1	Homo sapiens	8-12
23160832-3	2013	Neuroglobin and cytoglobin have been suggested as novel therapeutic targets in various neurodegenerative diseases based on their oxygen binding and cell protecting properties.	Oxygen	129-135	neuroglobin	Homo sapiens	0-11
23658877-1	2013	The development of immediate and delayed long-term resistance to hypoxia during a course of intermittent normobaric hypoxia (15 daily sessions of alternating exposure to 10% O2 and atmospheric air for 1 h) correlated with biphasic expression of HIF-1alpha in neocortex of hypoxia-intolerant rats, which suggests involvement of this protein factor not only in the formation of long-term adaptation, but also in triggering immediate adaptation to hypoxia.	Oxygen	174-176	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	245-255
22865553-0	2012	NOX2 (gp91phox) is a predominant O2 sensor in a human airway chemoreceptor cell line: biochemical, molecular, and electrophysiological evidence.	Oxygen	33-35	cytochrome b-245 beta chain	Homo sapiens	0-4
22865553-0	2012	NOX2 (gp91phox) is a predominant O2 sensor in a human airway chemoreceptor cell line: biochemical, molecular, and electrophysiological evidence.	Oxygen	33-35	cytochrome b-245 beta chain	Homo sapiens	6-14
22915309-5	2012	The MSIT-related blood oxygen level-dependent (BOLD) response was increased with increasing copies of the TPH2 yin haplotype for the dorsal anterior cingulate cortex (dACC), right inferior frontal cortex (IFC), and anterior striatum.	Oxygen	23-29	tryptophan hydroxylase 2	Homo sapiens	106-110
23025608-3	2012	We used a novel in situ method (permeabilized fibers) that allowed us to accurately measure the consumption of oxygen by mitochondria in constructed siII-introgressed flies and in siIII-control flies.	Oxygen	111-117	elongin B	Homo sapiens	149-153
23537261-0	2013	Sustained exposure to cytokines and hypoxia enhances excitability of oxygen-sensitive type I cells in rat carotid body: correlation with the expression of HIF-1alpha protein and adrenomedullin.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	155-165
10201397-2	1999	Thiophilic metal ions such as Mn2+, Zn2+ or Cd2+ rescue the &gt;10(3)-fold inhibitory effect of sulfur substitution of the 3"-oxygen leaving group but do not effectively rescue the effect of sulfur substitution of the nonbridging pro-Sp phosphoryl oxygen.	Oxygen	126-132	CD2 molecule	Homo sapiens	44-47
23537261-3	2013	The present study examines the hypothesis that selected cytokines enhance the excitability of oxygen-sensitive type I cells in the carotid body, and that downstream effects of cytokines involve upregulation of the transcription factor, hypoxia inducible factor-1alpha (HIF-1alpha).	Oxygen	94-100	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	236-267
23334390-1	2013	pO2 in the kidney is maintained at relatively stable levels by a unique and complex functional interplay between renal blood flow, GFR, O2 consumption, and arteriovenous O2 shunting.	Oxygen	1-3	Rap guanine nucleotide exchange factor 5	Homo sapiens	131-134
22615268-0	2012	Cardiopulmonary hemodynamic responses to the small injection of hemoglobin vesicles (artificial oxygen carriers) in miniature pigs.	Oxygen	96-102	HGB	Sus scrofa	64-74
22615268-2	2012	Hemoglobin vesicles (HbVs) are artificial oxygen carriers encapsulating Hb solution in liposomes.	Oxygen	42-48	HGB	Sus scrofa	0-10
10201397-2	1999	Thiophilic metal ions such as Mn2+, Zn2+ or Cd2+ rescue the &gt;10(3)-fold inhibitory effect of sulfur substitution of the 3"-oxygen leaving group but do not effectively rescue the effect of sulfur substitution of the nonbridging pro-Sp phosphoryl oxygen.	Oxygen	248-254	CD2 molecule	Homo sapiens	44-47
10221347-7	1999	We also verified that the ability to protect neurons in hypoxia and oxygen reperfusion was as follows: idebenone &gt; insulin-like growth factor-1 (IGF-1) &gt; nilvadipine.	Oxygen	68-74	insulin-like growth factor 1	Rattus norvegicus	118-146
23020790-0	2012	Study of the oxygen vacancy influence on magnetic properties of Fe- and Co-doped SnO2 diluted alloys.	Oxygen	13-19	strawberry notch homolog 2	Homo sapiens	81-84
23039021-11	2013	In BeWo cells, culture in reduced oxygen tension and/or serum depleted conditions led to the appearance of autophagosomes which was associated with changes in LAMP-2 configuration.	Oxygen	34-40	lysosomal associated membrane protein 2	Homo sapiens	159-165
10221347-7	1999	We also verified that the ability to protect neurons in hypoxia and oxygen reperfusion was as follows: idebenone &gt; insulin-like growth factor-1 (IGF-1) &gt; nilvadipine.	Oxygen	68-74	insulin-like growth factor 1	Rattus norvegicus	148-153
22889262-4	2012	We use density functional theory quantum chemical calculations to ascribe the drop in mobility to the formation of a shallow, localized, oxygen-induced trap level, 0.34 eV below the delocalized lowest unoccupied molecular orbital of P(NDI2OD-T2).	Oxygen	137-143	TRAP	Homo sapiens	152-156
10048030-8	1999	In P. stipitis, transcription of SUT1 was strongly induced by glucose and was independent of the oxygen supply.	Oxygen	97-103	Sut1p	Saccharomyces cerevisiae S288C	33-37
22917272-4	2012	In support of the regulation of COX Vb expression by the Ras family, we also found that selective siRNA-mediated inhibition of K-Ras expression in A549 lung adenocarcinoma cells reduced COX Vb protein expression, COX activity, oxygen consumption and the steady-state concentration of ATP.	Oxygen	227-233	KRAS proto-oncogene, GTPase	Homo sapiens	127-132
22917272-6	2012	We transfected the A549 cells with COX Vb small interfering or shRNA and observed a significant reduction of their COX activity, oxygen consumption, ATP and ability to grow in soft agar and as poorly differentiated tumors in athymic mice.	Oxygen	129-135	cytochrome c oxidase subunit 4I1	Mus musculus	35-38
23292657-0	2013	The combination of an oxygen-dependent degradation domain-regulated             adenovirus expressing the chemokine RANTES/CCL5 and NK-92 cells exerts enhanced             antitumor activity in hepatocellular carcinoma.	Oxygen	22-28	C-C motif chemokine ligand 5	Homo sapiens	116-122
23292657-0	2013	The combination of an oxygen-dependent degradation domain-regulated             adenovirus expressing the chemokine RANTES/CCL5 and NK-92 cells exerts enhanced             antitumor activity in hepatocellular carcinoma.	Oxygen	22-28	C-C motif chemokine ligand 5	Homo sapiens	123-127
23292657-4	2013	Therefore, we constructed             an adenovirus vector expressing the human RANTES/CCL5 gene regulated by oxygen-dependent             degradation domain (ODD) and analyzed its antitumor effects in vitro and in vivo.	Oxygen	110-116	C-C motif chemokine ligand 5	Homo sapiens	80-86
23292657-4	2013	Therefore, we constructed             an adenovirus vector expressing the human RANTES/CCL5 gene regulated by oxygen-dependent             degradation domain (ODD) and analyzed its antitumor effects in vitro and in vivo.	Oxygen	110-116	C-C motif chemokine ligand 5	Homo sapiens	87-91
9927052-2	1999	Here, we demonstrated a pronounced elevation of H2O2 and O2- in human leukemia HL-60 cells treated with beta-Lap.	Oxygen	50-52	LAP	Homo sapiens	109-112
23363049-8	2013	We also investigate an RFP variant known to be significantly less photostable than mCherry and find much easier oxygen access in this variant.	Oxygen	112-118	tripartite motif containing 27	Homo sapiens	23-26
22823179-9	2012	Hence, perhaps contrary to expectation, SRB lowered pitting corrosion rates under conditions of oxygen ingress due to their ability to respire oxygen and produce a less aggressive form of sulfur.	Oxygen	96-102	chaperonin containing TCP1 subunit 4	Homo sapiens	40-43
22823179-9	2012	Hence, perhaps contrary to expectation, SRB lowered pitting corrosion rates under conditions of oxygen ingress due to their ability to respire oxygen and produce a less aggressive form of sulfur.	Oxygen	143-149	chaperonin containing TCP1 subunit 4	Homo sapiens	40-43
22634106-1	2012	An online immobilized glucose oxidase (GOx) capillary microreactor was developed based on an enzymatic redox reaction with 1,4-benzoquinone as an acceptor of electrons, replacing the molecular oxygen typically used in a GOx reaction to achieve direct ultraviolet detection without derivation.	Oxygen	193-199	hydroxyacid oxidase 1	Homo sapiens	22-37
22634106-1	2012	An online immobilized glucose oxidase (GOx) capillary microreactor was developed based on an enzymatic redox reaction with 1,4-benzoquinone as an acceptor of electrons, replacing the molecular oxygen typically used in a GOx reaction to achieve direct ultraviolet detection without derivation.	Oxygen	193-199	hydroxyacid oxidase 1	Homo sapiens	39-42
22615433-5	2012	Human CBs express most of the genes previously proposed to be involved in oxygen sensing and signalling based on animal studies, including NOX2, AMPK, CSE and oxygen sensitive K+ channels.	Oxygen	74-80	cytochrome b-245 beta chain	Homo sapiens	139-143
23262504-1	2013	Neuroglobin (Ngb), a protein located in the mammal"s brain, is involved in oxygen transport and free radical scavenging inside the neurons.	Oxygen	75-81	neuroglobin	Homo sapiens	0-11
23262504-1	2013	Neuroglobin (Ngb), a protein located in the mammal"s brain, is involved in oxygen transport and free radical scavenging inside the neurons.	Oxygen	75-81	neuroglobin	Homo sapiens	13-16
23289639-5	2013	However, efficient mediated electron transfer (MET) occurs if an appropriate electron mediator is placed in solution, or the natural electron mediator oxygen is used, indicating that GOx is adsorbed and active on CNT/N-CNT electrodes.	Oxygen	151-157	hydroxyacid oxidase 1	Homo sapiens	183-186
10709635-2	1999	gamma-Butyrobetaine hydroxylase catalyse the last step in carnitine biosynthesis, the formation of L-carnitine from gamma-butyrobetaine, a reaction dependent on Fe2+, alpha-ketoglutarate, ascorbate and oxygen.	Oxygen	202-208	gamma-butyrobetaine hydroxylase 1	Rattus norvegicus	0-31
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Oxygen	46-52	aconitase 1	Mus musculus	4-8
22669977-2	2012	Recently, we discovered that opticin possesses anti-angiogenic activity using a murine oxygen-induced retinopathy model: here, we investigate the underlying mechanism.	Oxygen	87-93	opticin	Mus musculus	29-36
9934912-13	1999	However, TNF-alpha infusion significantly increased the oxygen cost of contractility by 40% (1.25+/-0.13 vs. 1.75+/-0.24 mL oxygen.mL/mm Hg/beat, p&lt; .05), indicating that MVo2 for the excitation-contraction coupling increased.	Oxygen	56-62	tumor necrosis factor	Canis lupus familiaris	9-18
22934072-7	2012	Anoxia induced by O(2)-glucose deprivation and severe hypoxia (1% O(2)) activates TRPM7 and TRPC6, respectively, whereas TRPA1 has recently been identified as a novel sensor of hyperoxia and mild hypoxia (15% O(2)) in vagal and sensory neurons.	Oxygen	18-22	transient receptor potential cation channel subfamily M member 7	Homo sapiens	82-87
22934072-7	2012	Anoxia induced by O(2)-glucose deprivation and severe hypoxia (1% O(2)) activates TRPM7 and TRPC6, respectively, whereas TRPA1 has recently been identified as a novel sensor of hyperoxia and mild hypoxia (15% O(2)) in vagal and sensory neurons.	Oxygen	66-71	transient receptor potential cation channel subfamily M member 7	Homo sapiens	82-87
22992176-0	2013	Swine hemoglobin as a potential source of artificial oxygen carriers, hemoglobin-vesicles.	Oxygen	53-59	HGB	Sus scrofa	6-16
22992176-1	2013	Hemoglobin-based oxygen carriers (HBOCs) have been developed as a transfusion alternative and oxygen therapy.	Oxygen	17-23	HGB	Sus scrofa	0-10
22992176-1	2013	Hemoglobin-based oxygen carriers (HBOCs) have been developed as a transfusion alternative and oxygen therapy.	Oxygen	94-100	HGB	Sus scrofa	0-10
23201463-2	2013	MetHb is produced in the RBC by irreversible NO-induced oxidation of the oxygen carrying ferrous ion (Fe(2+)) present in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe(3+)).	Oxygen	179-185	hemoglobin subunit gamma 2	Homo sapiens	0-5
9934912-13	1999	However, TNF-alpha infusion significantly increased the oxygen cost of contractility by 40% (1.25+/-0.13 vs. 1.75+/-0.24 mL oxygen.mL/mm Hg/beat, p&lt; .05), indicating that MVo2 for the excitation-contraction coupling increased.	Oxygen	124-130	tumor necrosis factor	Canis lupus familiaris	9-18
9864251-1	1999	Salmonella typhimurium zwf mutants lacking glucose 6-phosphate dehydrogenase (G6PD) activity have increased susceptibility to reactive oxygen and nitrogen intermediates as well as attenuated virulence in mice.	Oxygen	135-141	glucose-6-phosphate dehydrogenase 2	Mus musculus	43-76
23276385-7	2013	Placental hypoxia is a hallmark of pre-eclampsia; therefore explants were subjected to hypoxic culture conditions to determine the effect of oxygen on DUSP9 expression in vitro.	Oxygen	141-147	dual specificity phosphatase 9	Homo sapiens	151-156
23276385-11	2013	DUSP9 expression in first trimester explants was significantly decreased by 74 +- 20% in hypoxic (3% oxygen) culture conditions.	Oxygen	101-107	dual specificity phosphatase 9	Homo sapiens	0-5
22553921-6	2012	We demonstrate oxygen concentration sensitive net reduction of 2-nitro-6-benzyloxypurine by cytochrome P450 reductase, xanthine oxidase, and EMT6, DU145, and HL-60 cells to yield O(6)-benzylguanine.	Oxygen	15-21	xanthine dehydrogenase	Mus musculus	119-135
9864251-1	1999	Salmonella typhimurium zwf mutants lacking glucose 6-phosphate dehydrogenase (G6PD) activity have increased susceptibility to reactive oxygen and nitrogen intermediates as well as attenuated virulence in mice.	Oxygen	135-141	glucose-6-phosphate dehydrogenase 2	Mus musculus	78-82
22075642-1	2012	Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance.	Oxygen	121-127	glucose-6-phosphate dehydrogenase	Homo sapiens	28-61
16232554-3	1999	(i) C is oxidized in the presence of FMN and oxygen under near-ultraviolet light (C(OX1)).	Oxygen	45-51	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	82-87
22075642-1	2012	Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance.	Oxygen	121-127	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
22075642-1	2012	Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance.	Oxygen	176-182	glucose-6-phosphate dehydrogenase	Homo sapiens	28-61
22075642-1	2012	Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance.	Oxygen	176-182	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
22075642-1	2012	Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance.	Oxygen	176-182	glucose-6-phosphate dehydrogenase	Homo sapiens	226-230
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Oxygen	128-134	iron responsive element binding protein 2	Mus musculus	164-168
23505621-3	2013	The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of the UCP2 and UCP3 genes.	Oxygen	69-75	uncoupling protein 3	Homo sapiens	120-124
23224890-5	2013	Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.	Oxygen	108-114	T cell leukemia homeobox 2	Homo sapiens	11-14
22870577-0	2012	The correlation between serum amyloid A and reactive oxygen metabolites in a young Mongolian population.	Oxygen	53-59	serum amyloid A1 cluster	Homo sapiens	24-39
22742080-6	2012	Oxygen uptake was significantly elevated at RE2 relative to RE3, RE4 and RE5 but was not different from RE1.	Oxygen	0-6	G protein-coupled receptor 161	Homo sapiens	44-47
10447219-0	1999	Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway.	Oxygen	78-84	Rh associated glycoprotein	Homo sapiens	12-16
22616860-7	2012	In the present mini-review, recent developments in our understanding of how the TDO class of enzymes use activated molecular oxygen to break the indole ring are discussed.	Oxygen	125-131	tryptophan 2,3-dioxygenase	Homo sapiens	80-83
22408042-7	2012	Interestingly, levels of monocyte chemoattractant protein (MCP)-1 were equivalently elevated in infected mice that had been exposed to 80% or 100% oxygen as neonates.	Oxygen	147-153	chemokine (C-C motif) ligand 2	Mus musculus	25-65
9922708-20	1999	Next, we examined mechanism to shut off the O2- production, and found that the inactivation through disassembly of the constituents was attained by dephosphorylation of phosphorylated p47-phox by cytosolic protein phosphatase.	Oxygen	44-46	pleckstrin	Homo sapiens	184-187
22444276-0	2012	Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma.	Oxygen	11-17	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	111-159
9866708-5	1998	Incubation of CYP2C9 under oxygen-18 gas showed that all HETEs had incorporated oxygen-18 to the same degree.	Oxygen	27-33	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	14-20
21254897-3	2012	Activation of the classical, alternative, and lectin complement pathways and the generation of the anaphylatoxins C3a and C5a lead to recruitment of polymorphonuclear leukocytes, generation of radical oxygen species, up-regulation of adhesion molecules on the endothelium and platelets, and induction of cytokine release.	Oxygen	201-207	complement C3	Homo sapiens	114-117
9866708-5	1998	Incubation of CYP2C9 under oxygen-18 gas showed that all HETEs had incorporated oxygen-18 to the same degree.	Oxygen	80-86	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	14-20
22494481-4	2012	Compared with the tap water condition, tissue oxygenation index was 3.5% +- 1.3% higher in feet treated for 30 min with O(2)-infused water.	Oxygen	120-124	nuclear RNA export factor 1	Homo sapiens	18-21
9832630-2	1998	In humans, BPGM occurs only in erythrocytes and plays a pivotal role in the dissociation of oxygen from hemoglobin via 2,3-DPG.	Oxygen	92-98	bisphosphoglycerate mutase	Homo sapiens	11-15
22364128-2	2012	However, TSPO is also involved in other pathways and cell functions, such as apoptosis regulation, protein import, membrane biogenesis, cell cycle regulation, oxygen homeostasis and mitochondrial membrane fluidity regulation.	Oxygen	159-165	translocator protein	Homo sapiens	9-13
9894911-1	1998	Transcriptional regulation of the yeast cytochrome c1 gene (CYT1) in response to oxygen and carbon source is mediated by Haplp and the Hap2 complex.	Oxygen	81-87	transcription activator HAP2	Saccharomyces cerevisiae S288C	135-139
22153387-13	2012	CONCLUSIONS: According to our hypothesis, high-flow oxygen therapy systems produced a low-level CPAP in an experimental pediatric model, even with the use of very high flow rates.	Oxygen	52-58	centromere protein J	Homo sapiens	96-100
22367737-4	2012	Herein, we demonstrate that exposure to atmospheric oxygen rapidly induced p53, TOP2A, and BCL2-associated X protein (BAX) expression and mitochondrial reactive oxygen species (ROS) generation in primary mouse MSCs resulting in oxidative stress, reduced cell viability, and inhibition of cell proliferation.	Oxygen	52-58	BCL2-associated X protein	Mus musculus	91-116
9819221-9	1998	We propose that the absence of hydrogen-bond formation between a distal residue and exogenous ligands is physiologically relevant in lowering the oxygen affinity of heterodimeric sGC and, therefore, stabilizing the ferrous, active form of the enzyme under aerobic conditions.	Oxygen	146-152	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	179-182
22367737-4	2012	Herein, we demonstrate that exposure to atmospheric oxygen rapidly induced p53, TOP2A, and BCL2-associated X protein (BAX) expression and mitochondrial reactive oxygen species (ROS) generation in primary mouse MSCs resulting in oxidative stress, reduced cell viability, and inhibition of cell proliferation.	Oxygen	52-58	BCL2-associated X protein	Mus musculus	118-121
22367737-5	2012	Alternatively, procurement and culture in 5% oxygen supported more prolific expansion of the CD45(-ve) /CD44(+ve) cell fraction in marrow, produced increased MSC yields following immunodepletion, and supported sustained MSC growth resulting in a 2,300-fold increase in cumulative cell yield by fourth passage.	Oxygen	45-51	CD44 antigen	Mus musculus	104-108
9824435-2	1998	Oxygen tension in the venous blood normally determine EPO elaboration, and, therefore, oxygen consumption in the kidney appears to be an essential part of the oxygen-sensing physiological mechanism.	Oxygen	0-6	erythropoietin	Mus musculus	54-57
22319766-9	2012	SAR demonstrated higher [-OH]/O2- ratio than SLA .	Oxygen	30-32	sarcosine dehydrogenase	Homo sapiens	0-3
9824435-3	1998	As renal oxygen consumption is closely linked to urine production, we have compared responsiveness of the EPO gene to diminished oxygen supply in the normal kidney with that of the hydronephrotic kidney, resulting from ureter ligation.	Oxygen	129-135	erythropoietin	Mus musculus	106-109
9804151-7	1998	After P27, the relationship between oxygen and photoreceptor death changed markedly, hyperoxia no longer delaying and hypoxia no longer accelerating death.	Oxygen	36-42	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	6-9
9876984-2	1998	In sepsis and inflammation, when synthesis of NO, oxygen radicals and toxic metabolites is crucial, the expression of tissue factor (TF) on monocytes stimulated by lipopolysaccharides (LPS) induces intravascular coagulation.	Oxygen	50-56	coagulation factor III, tissue factor	Homo sapiens	118-131
9876984-2	1998	In sepsis and inflammation, when synthesis of NO, oxygen radicals and toxic metabolites is crucial, the expression of tissue factor (TF) on monocytes stimulated by lipopolysaccharides (LPS) induces intravascular coagulation.	Oxygen	50-56	coagulation factor III, tissue factor	Homo sapiens	133-135
9823769-5	1998	In addition, it appeared that oxygen radicals functioned as activating molecules during cellular interaction and production of MIP-1alpha, as the addition of the antioxidant N-acetylcysteine (NAC) prevented MIP-1alpha secretion.	Oxygen	30-36	chemokine (C-C motif) ligand 3	Mus musculus	127-137
9823769-5	1998	In addition, it appeared that oxygen radicals functioned as activating molecules during cellular interaction and production of MIP-1alpha, as the addition of the antioxidant N-acetylcysteine (NAC) prevented MIP-1alpha secretion.	Oxygen	30-36	chemokine (C-C motif) ligand 3	Mus musculus	207-217
9763626-10	1998	PKA enzyme activity was significantly inhibited when PC12 cells were exposed to 10% O2 for 24 and 48 h. However, we found that hypoxia failed to induce change in adenosine- and forskolin-stimulated adenylate cyclase enzyme activity.	Oxygen	84-86	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-3
9763626-13	1998	Whole cell patch-clamp analysis showed that the effect of 8-bromo-cAMP, an activator of PKA, on ICa was significantly attenuated during 48 h exposure to 10% O2.7.	Oxygen	157-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	88-91
9801822-1	1998	We describe here the synthesis and the biological activity of a "C-pentasaccharide", a new analogue of the antithrombin III (AT III) binding region of heparin containing a methylene bridge in place of an interglycosidic oxygen atom.	Oxygen	220-226	serpin family C member 1	Homo sapiens	125-131
9726236-11	1998	In addition, the beta3-AR agonist, CGP-12177, stimulated oxygen consumption in mice expressing human but not murine beta3-ARs by 91% compared with only 49% in control beta3-AR gene knockout mice, demonstrating that the human beta3-AR can functionally couple with energy expenditure.	Oxygen	57-63	adrenergic receptor, beta 3	Mus musculus	17-25
9746434-7	1998	CONCLUSIONS: Both glucose and pH significantly affected VEGF production induced by low oxygen.	Oxygen	87-93	vascular endothelial growth factor A	Rattus norvegicus	56-60
9690226-7	1998	Moreover, in the absence of any significant cytotoxic effects due to both the types of material studied, the production of oxygen free radicals and nitric oxide (NO) by leukocytes was higher after their in vitro exposure to CL-S, but was quite similar to that of the control leukocytes after exposure to CL-E.	Oxygen	123-129	cardiolipin synthase 1	Homo sapiens	224-228
9701579-5	1998	When overexpressed in yeast lacking the superoxide dismutase gene SOD1, both ATX1 and CCH protected the cell from the reactive oxygen toxicity that results from superoxide dismutase deficiency.	Oxygen	127-133	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	77-81
9635141-5	1998	The generation of active oxygen species by flavocytochrome 2B4 was registered by chemiluminescence intensity.	Oxygen	25-31	CD244 molecule	Homo sapiens	59-62
22877935-3	2013	This kind of nanocatalysts could provide a kind of nanoreactors to promote the degradation of NH(4)SCN into simple inorganic compounds such as SO(4)(2-), HCO(3)(-) and NO(3)(-) using oxygen as an oxidant under room conditions.	Oxygen	183-189	sorcin	Homo sapiens	99-102
9606183-1	1998	The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible transcription factor (HIF-1), a heterodimer consisting of the constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha.	Oxygen	40-46	aryl hydrocarbon receptor nuclear translocator	Mus musculus	178-224
9606183-1	1998	The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible transcription factor (HIF-1), a heterodimer consisting of the constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha.	Oxygen	40-46	aryl hydrocarbon receptor nuclear translocator	Mus musculus	226-230
9606183-1	1998	The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible transcription factor (HIF-1), a heterodimer consisting of the constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha.	Oxygen	40-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	264-274
9663696-0	1998	Mitochondrial swelling and oxygen consumption during respiratory state 4 induced by phospholipase A2 isoforms isolated from the South American rattlesnake (Crotalus durissus terrificus) venom.	Oxygen	27-33	phospholipase A2 group IB	Rattus norvegicus	84-100
9663696-3	1998	The effect of each purified phospholipase A2 isoform on isolated rat liver mitochondria was determined through mitochondrial swelling and O2 consumption during respiratory state 4.	Oxygen	138-140	phospholipase A2 group IB	Rattus norvegicus	28-44
9663696-8	1998	These results suggest that free fatty acids are directly responsible for the observed effects induced by phospholipase A2 isoforms on oxygen consumption experiments.	Oxygen	134-140	phospholipase A2 group IB	Rattus norvegicus	105-121
9645472-1	1998	To analyze the potential of the active oxygen-scavenging system of chloroplasts, we introduced Escherichia coli catalase into tobacco chloroplasts.	Oxygen	39-45	catalase isozyme 1	Nicotiana tabacum	112-120
9626590-7	1998	Because CYP3A4 is present in high amounts in human liver microsomes and is active in catalyzing the formation of reactive oxygen species, this CYP may make an important contribution in the overall ability of human liver microsomes to generate active oxygen species.	Oxygen	122-128	peptidylprolyl isomerase G	Homo sapiens	8-11
9556556-12	1998	A model for the interaction between TrxR and dinitrohalobenzenes is proposed, involving a functional FAD in the alkylated TrxR generating an anion nitroradical in a dinitrophenyl group, which in turn reacts with oxygen to generate superoxide.	Oxygen	212-218	peroxiredoxin 5	Homo sapiens	36-40
22653900-4	2012	Physiologically, superoxide is immediately transformed into hydrogen peroxide and diatomic oxygen with manganese superoxide dismutase (MnSOD).	Oxygen	91-97	superoxide dismutase 2	Rattus norvegicus	103-133
22653900-4	2012	Physiologically, superoxide is immediately transformed into hydrogen peroxide and diatomic oxygen with manganese superoxide dismutase (MnSOD).	Oxygen	91-97	superoxide dismutase 2	Rattus norvegicus	135-140
9556556-12	1998	A model for the interaction between TrxR and dinitrohalobenzenes is proposed, involving a functional FAD in the alkylated TrxR generating an anion nitroradical in a dinitrophenyl group, which in turn reacts with oxygen to generate superoxide.	Oxygen	212-218	peroxiredoxin 5	Homo sapiens	122-126
9580611-10	1998	Because Cbl(III)O2- is spontaneously regenerated from Cbl(II) and O2 in aerated solutions, this may constitute a cyclic mechanism for the rapid elimination (oxidation) of NO.	Oxygen	16-18	Cbl proto-oncogene	Homo sapiens	8-11
22395314-3	2012	Three HIF prolyl hydroxylase enzymes (PHD1, PHD2 and PHD3) function as oxygen sensing enzymes, which regulate the activity of HIFs in normoxic and hypoxic conditions.	Oxygen	71-77	egl-9 family hypoxia inducible factor 3	Homo sapiens	53-57
9584985-5	1998	Thus, the enhancement of the active oxygen-scavenging system that was induced by low temperature in potato tubers could result not only in a decrease of AsA but also in combined increases in APx and CAT activity whose manners were different.	Oxygen	36-42	L-ascorbate peroxidase 1, cytosolic-like	Solanum tuberosum	191-194
22020754-2	2012	Despite the severe sensitivity of HYD1 towards oxygen, a sustained and relatively high photosynthetic hydrogen evolution capacity is established in C. reinhardtii cultures when deprived of sulfur.	Oxygen	47-53	uncharacterized protein	Chlamydomonas reinhardtii	34-38
22198378-6	2012	ATP13A2-deficient cells exhibited increased oxygen consumption without a significant change in steady-state levels of ATP.	Oxygen	44-50	ATPase cation transporting 13A2	Homo sapiens	0-7
9537339-8	1998	The increased MCP-1 levels in CHF were correlated with increased monocyte activity reflected in an enhancing effect of serum from CHF patients on O2-generation in monocytes, which was inhibited by neutralizing antibodies against MCP-1.	Oxygen	146-148	C-C motif chemokine ligand 2	Homo sapiens	14-19
22198378-9	2012	The effects of ATP13A2 siRNA on oxygen consumption, mitochondrial mass and ROS production could be mimicked by inhibiting autophagy induction using siRNA to Atg7.	Oxygen	32-38	ATPase cation transporting 13A2	Homo sapiens	15-22
22045754-0	2012	Expression and uptake of the thyroxine-binding protein transthyretin is regulated by oxygen in primary trophoblast placental cells.	Oxygen	85-91	transthyretin	Homo sapiens	55-68
22045754-7	2012	We observed significantly higher uptake of 125I-TTR and Alexa-594-TTR when cells were cultured at 1 and 3% O2 and in the presence of 200 muM DFO than at 8 and 21% O2.	Oxygen	107-109	transthyretin	Homo sapiens	48-51
22045754-7	2012	We observed significantly higher uptake of 125I-TTR and Alexa-594-TTR when cells were cultured at 1 and 3% O2 and in the presence of 200 muM DFO than at 8 and 21% O2.	Oxygen	163-165	transthyretin	Homo sapiens	48-51
22045754-8	2012	When JEG-3 choriocarcinoma cells were transfected with TTR promoter reporter constructs, increased luciferase activity was measured in cells cultured at 1 and 3% O2 in comparison to 8 and 21% O2.	Oxygen	162-164	transthyretin	Homo sapiens	55-58
22045754-8	2012	When JEG-3 choriocarcinoma cells were transfected with TTR promoter reporter constructs, increased luciferase activity was measured in cells cultured at 1 and 3% O2 in comparison to 8 and 21% O2.	Oxygen	192-194	transthyretin	Homo sapiens	55-58
22302823-9	2012	Oxygen/glucose deprivation-induced injury in organotypic hippocampal slice cultures confirmed that calpains were specifically activated during bax-dependent apoptosis and in this setting function as downstream cell-death executioners.	Oxygen	0-6	BCL2-associated X protein	Mus musculus	143-146
9537339-8	1998	The increased MCP-1 levels in CHF were correlated with increased monocyte activity reflected in an enhancing effect of serum from CHF patients on O2-generation in monocytes, which was inhibited by neutralizing antibodies against MCP-1.	Oxygen	146-148	C-C motif chemokine ligand 2	Homo sapiens	229-234
9675357-4	1998	From the comparison of results of a number of glycosylations via stannylene acetals, it appears that nucleophilicity of oxygens involved in the cis-1,2-acetals decreases in the order: equatorial anomeric &gt; equatorial non-anomeric &gt; axial anomeric.	Oxygen	120-127	cytokine inducible SH2 containing protein	Homo sapiens	144-149
22239407-1	2012	Protein dynamics of human adult hemoglobin (HbA) upon ligand photolysis of oxygen (O(2)) and carbon monoxide (CO) was investigated using time-resolved resonance Raman (TR(3)) spectroscopy.	Oxygen	75-81	keratin 90, pseudogene	Homo sapiens	44-47
22239407-1	2012	Protein dynamics of human adult hemoglobin (HbA) upon ligand photolysis of oxygen (O(2)) and carbon monoxide (CO) was investigated using time-resolved resonance Raman (TR(3)) spectroscopy.	Oxygen	83-87	keratin 90, pseudogene	Homo sapiens	44-47
22135092-9	2012	Furthermore, these data suggest that ATF4 status may be a critical determinant of the ability of cancer cells to adapt to oxygen and acidity fluctuations in the tumor microenvironment, perhaps linking short-term transcriptional responses to long-term selection for copy number alterations in cancer cells.	Oxygen	122-128	activating transcription factor 4	Homo sapiens	37-41
9518719-9	1998	Pa,O2 at VO2,max was inversely related to the alveolar to arterial O2 difference (A-aDO2) (r = -0.93; 35-52 mmHg) and to arterial PCO2 (Pa,CO2) (r = -0.62; 26-39 mmHg).	Oxygen	3-5	complement C2	Homo sapiens	136-142
22104347-3	2012	Recent works have shown that various growth factors and cytokines including IGF-1 can stimulate HIF-1alpha expression, thereby triggering transcription of numerous hypoxia-inducible genes by oxygen-independent mechanisms.	Oxygen	191-197	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	96-106
9521050-4	1998	We show that cross-linking of P-selectin glycoprotein ligand-1 (PSGL-1) on mouse neutrophils with an antibody-like recombinant form of P-selectin or with monoclonal antibodies stimulated the production of reactive oxygen intermediates and enhanced neutrophil attachment to intercellular adhesion molecule 1 (ICAM-1)-expressing CHO cells.	Oxygen	214-220	selectin, platelet (p-selectin) ligand	Mus musculus	64-70
9490763-3	1998	Here we show that in isolated tuber mitochondria FDH is involved in formate-dependent O2 uptake coupled to ATP synthesis.	Oxygen	86-88	formate dehydrogenase, mitochondrial	Solanum tuberosum	49-52
22009797-6	2012	Hypoxia (1% O(2)) or treatment with hypoxia-mimicking CoCl(2) enhanced RSUME and HIF-1alpha expression, induced translocation of HIF-1alpha to the nuclei and stimulated VEGF-A production both in pituitary tumour cell lines and primary human pituitary adenoma cell cultures.	Oxygen	12-16	RWD domain containing 3	Homo sapiens	71-76
23884820-0	2013	Effect of HMGB1/NF-kappaB in hyperbaric oxygen treatment on decreasing injury caused by skin flap grafts in rats.	Oxygen	40-46	high mobility group box 1	Rattus norvegicus	10-15
9475178-4	1998	The role of Trx in nucleotide metabolism and gene expression may be an explanation for increased chromosomal instability as well as hypersensitivity towards oxygen, ROI and ROI generating agents.	Oxygen	157-163	thioredoxin	Homo sapiens	12-15
23849870-6	2013	We also introduce a convenient method to normalize cellular respiration to cell density allowing measurement of UCP2 effects on specific mitochondrial oxygen consumption.	Oxygen	151-157	uncoupling protein 2	Rattus norvegicus	112-116
22239772-4	2012	This paper makes a comparative assessment of the different approaches by applying them to potential energy surfaces for different spin states of the oxygen and carbon dimer.	Oxygen	149-155	spindlin 1	Homo sapiens	130-134
22937490-5	2012	Interestingly, these enzymes are oxygen sensitive genes and regulated by transcription factor hypoxia-inducible factor (HIF)-1alpha.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	94-131
9439610-4	1998	Chronic (&gt; 6 hr), but not acute exposure to hypoxia (5% O2) significantly decreased both PKA enzyme activity and immunoreactivity compared to control levels.	Oxygen	59-61	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	92-95
21952037-8	2012	Stable knockdown of PON3 using short-hairpin RNA reduced cell proliferation in 21% oxygen.	Oxygen	83-89	paraoxonase 3	Homo sapiens	20-24
21952037-9	2012	We then studied the effect of transient knockdown of PON3 using short interfering RNA (siRNA) in the same cell line in low (2%) or ambient (21%) oxygen.	Oxygen	145-151	paraoxonase 3	Homo sapiens	53-57
23634236-1	2013	Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders.	Oxygen	24-30	neuroglobin	Homo sapiens	0-11
23634236-1	2013	Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders.	Oxygen	24-30	neuroglobin	Homo sapiens	13-16
21952037-10	2012	Knockdown of PON3 using siRNA reduced total antioxidant capacity in 21% (P = 0.008) but not 2% oxygen.	Oxygen	95-101	paraoxonase 3	Homo sapiens	13-17
9889930-3	1998	Myoglobin-facilitated oxygen diffusion may be augmented by the same mechanism.	Oxygen	22-28	myoglobin	Homo sapiens	0-9
23300486-2	2013	It results from the activity of an alternative oxidase (AOX) that conveys electrons directly from the respiratory chain (RC) ubiquinol pool to oxygen.	Oxygen	143-149	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	35-54
23300486-2	2013	It results from the activity of an alternative oxidase (AOX) that conveys electrons directly from the respiratory chain (RC) ubiquinol pool to oxygen.	Oxygen	143-149	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	56-59
23091723-6	2012	Finally, the protein CHCHD4, which modulates cellular HIF-1alpha concentrations by promoting mitochondrial electron transport chain activity, has been proposed to exert its regulatory effect by affecting cellular oxygen availability.	Oxygen	213-219	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	21-27
23231391-9	2012	Different families of nitrogen and oxygen heterocycles, such as pyrazoles, hydrazinylthiazoles, xanthones, coumarins or chromones have also been extensively used as scaffolds in medicinal chemistry programs for searching novel MAO-B inhibitors.	Oxygen	35-41	monoamine oxidase B	Homo sapiens	227-232
23231395-1	2012	In neurodegenerative disorders, including Parkinson"s and Alzheimer"s diseases, type B monoamine oxidase (MAO-B) has been proposed to play a primary role though generating reactive oxygen species in oxidation of monoamine substrates.	Oxygen	181-187	monoamine oxidase B	Homo sapiens	106-111
23308255-6	2013	Mutant cardiac muscles showed decreased rates of oxygen consumption and ATP production, suggesting that Crif1 plays a critical role in the maintenance of both mitochondrial structure and respiration in cardiac muscles.	Oxygen	49-55	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	104-109
24171321-1	2013	Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to bring about the reduction of oxygen to water.	Oxygen	104-110	cytochrome c oxidase subunit 7A1	Bos taurus	22-25
24225107-4	2013	The results show that a selective degradation of AOX with respect to the matrix compounds (expressed as chemical oxygen demand) could be achieved.	Oxygen	113-119	acyl-CoA oxidase 1	Homo sapiens	49-52
9889930-4	1998	In this study, parameters of an oxygen transport to tissue model are optimized to investigate the possibility of elevated diffusion coefficients for oxygen and myoglobin in working heart tissue.	Oxygen	32-38	myoglobin	Homo sapiens	160-169
22899923-9	2012	Two SNPs in the CREB1 gene (rs2253206 and 2360969) were related to change in temperature during exercise and with maximal oxygen capacity (VO(2) max).	Oxygen	122-128	cAMP responsive element binding protein 1	Homo sapiens	16-21
9439587-14	1998	The sequence alignment of cytochrome P4501A1 with cytochrome P450102 predicts that this region might correspond to beta-sheet structure localized on the distal side of the heme ring near the I helix and the oxygen binding pocket.	Oxygen	207-213	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-44
21989481-1	2012	Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones.	Oxygen	19-25	small ubiquitin like modifier 2	Homo sapiens	116-122
23336160-9	2013	CONCLUSIONS: INSURE method can improve the oxygenation function of the lung, decrease the incidence of VAP and shorten the duration of oxygen therapy in neonates with NRDS, which is probably due to the fact that this method can reduce the production of TNF-alpha and SF and inhibit the decrease of IL-10.	Oxygen	43-49	interleukin 10	Homo sapiens	298-303
9473610-7	1998	Vulnerable neurons in the CA1 region of slices deprived of oxygen and glucose became increasingly permeant to ethidium homodimer over the 4 h reperfusion period.	Oxygen	59-65	carbonic anhydrase 1	Rattus norvegicus	26-29
23172673-4	2012	In particular, our measured scattering-length contrast of 0.204(3) fm between (18)O and (nat)O is nearly a factor of 6 greater than the tabulated value, which renders feasible neutron diffraction experiments using (18)O isotope substitution and thereby offers new possibilities for measuring the partial structure factors of oxygen-containing compounds, such as water.	Oxygen	325-331	bromodomain containing 2	Homo sapiens	89-92
22894113-5	2012	TPR analysis revealed that Fe introduction into ceria strongly modified the textual and structural properties, which influenced the oxygen handling properties.	Oxygen	132-138	translocated promoter region, nuclear basket protein	Homo sapiens	0-3
9777366-0	1998	Evidence for upregulation and redistribution of vascular endothelial growth factor (VEGF) receptors flt-1 and flk-1 in the oxygen-injured rat retina.	Oxygen	123-129	vascular endothelial growth factor A	Rattus norvegicus	48-82
21590721-1	2012	Recently, a T(2) -Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to quantitatively estimate blood oxygen saturation fraction (Y) via the measurement of pure blood T(2) .	Oxygen	117-123	solute carrier family 25 member 5	Homo sapiens	12-16
22907804-11	2012	Finally, our in vitro hypoxia-ischemia model, using A172 glioma cells and primary astrocytes, showed that downregulation of Bis blocked the enhanced expression of galectin 3 after oxygen-glucose deprivation.	Oxygen	180-186	BCL2-associated athanogene 3	Mus musculus	124-127
9777366-0	1998	Evidence for upregulation and redistribution of vascular endothelial growth factor (VEGF) receptors flt-1 and flk-1 in the oxygen-injured rat retina.	Oxygen	123-129	vascular endothelial growth factor A	Rattus norvegicus	84-88
9777366-0	1998	Evidence for upregulation and redistribution of vascular endothelial growth factor (VEGF) receptors flt-1 and flk-1 in the oxygen-injured rat retina.	Oxygen	123-129	kinase insert domain receptor	Rattus norvegicus	110-115
9777366-10	1998	Comparison of VEGF protein immunolabel with both of the VEGFR immunolabels revealed overlap and strong similarity on day 20 in the oxygen-injured eyes.	Oxygen	131-137	vascular endothelial growth factor A	Rattus norvegicus	14-18
22961008-0	2012	Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy.	Oxygen	18-24	egl-9 family hypoxia-inducible factor 2	Mus musculus	32-36
22761656-12	2012	CONCLUSION: Culture in 2% O(2) variably altered hsp expression in a panel of melanoma cell lines.	Oxygen	26-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-51
9706741-4	1998	We assessed the ability of myoglobin (Mb) or hemoglobin (Hb) to oxidize dihydrorhodamine (DHR) to rhodamine (RH) in the presence of O2-/H2O2 and/or NO.	Oxygen	132-134	myoglobin	Homo sapiens	27-36
22363741-5	2012	Furthermore, using RNA interference and over-expression strategies, we demonstrate that M19 modulates mitochondrial oxygen consumption and ATP production, and could therefore regulate the respiratory chain activity.	Oxygen	116-122	ubiquinol-cytochrome c reductase complex assembly factor 2	Rattus norvegicus	88-91
22961008-2	2012	HIF prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) are oxygen sensors involved in adaptive response to hypoxia.	Oxygen	58-64	egl-9 family hypoxia-inducible factor 2	Mus musculus	32-36
22936271-6	2012	PCR confirmed activation of HIF-downstream targets, GLUT1, IGF2, and VEGF under reduced O(2) levels (0.5%).	Oxygen	88-92	solute carrier family 2 member 1	Homo sapiens	52-57
23328296-2	2012	METHODS: Small interfering RNA against human LOX gene (LOX siRNA) was used to transfect lung cancer cells under normoxia (19%O2).	Oxygen	125-127	lysyl oxidase	Homo sapiens	45-48
23328296-2	2012	METHODS: Small interfering RNA against human LOX gene (LOX siRNA) was used to transfect lung cancer cells under normoxia (19%O2).	Oxygen	125-127	lysyl oxidase	Homo sapiens	55-58
9706741-12	1998	We conclude that in the presence of a hemoprotein such as myoglobin or hemoglobin, NO may promote or inhibit oxidation reactions depending upon the relative fluxes of O2-, H2O2, and NO.	Oxygen	167-169	myoglobin	Homo sapiens	58-67
22593698-7	2012	The addition of hyperbaric oxygen produces an extra benefit by improving oxidative injury and by inducing endothelial NO synthase (eNOS) gene expression.	Oxygen	27-33	nitric oxide synthase 3	Rattus norvegicus	131-135
9848145-3	1998	The study of the antioxidant system discovered the inhibition of various enzymes: superoxide dismutase and peroxidase, inhibiting production of active oxygen forms; transferring and ceruloplasmin as regulators of Fe2+/Fe3+ ratio, glutathione reductase and glutathione peroxidase influencing the ratio of oxidated and reduced glutathione forms and the level of SH-groups.	Oxygen	151-157	ceruloplasmin	Homo sapiens	182-195
22593698-9	2012	Interestingly, only the use of hyperbaric oxygen was associated to a blunted oxidative stress and an increased eNOS gene expression.	Oxygen	42-48	nitric oxide synthase 3	Rattus norvegicus	111-115
22065478-8	2011	Hydrogen bonding between the aliphatic substituents and the ether oxygen in the PPE derivatives has a significant influence on the BDE.	Oxygen	66-72	homeobox D13	Homo sapiens	131-134
22131155-9	2011	Nasal CPAP, BiPAP and adenotonsillectomy improved respiratory parameters.Pulse oxymetry can be used as a screening method because of the good correla-tion of oxygen desaturation index with severity of OSAS.	Oxygen	158-164	centromere protein J	Homo sapiens	6-10
23240562-4	2012	Transport of Ca2+ in cells is under constant influence of active forms of oxygen and nitrogen.	Oxygen	74-80	carbonic anhydrase 2	Homo sapiens	13-16
23240562-6	2012	The control of cardiac rhythm by active forms of oxygen and nitrogen represents a feedback mechanism by which mitochondria and NO-synthases support Ca2+ homeostasis in cells that can be temporarily disturbed under mechanical loads or hypoxia.	Oxygen	49-55	carbonic anhydrase 2	Homo sapiens	148-151
22524683-0	2012	Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?	Oxygen	71-77	cullin 7	Homo sapiens	0-8
22524683-2	2012	Cul7 or Fbxw8 deficiency is associated with intrauterine growth restriction (IUGR) due to abnormal placental development leading to poor oxygen supply to the fetus.	Oxygen	137-143	cullin 7	Homo sapiens	0-4
22885005-7	2012	Reducing TIN2 expression by RNAi knockdown inhibited glycolysis and reactive oxygen species (ROS) production and enhanced ATP levels and oxygen consumption in cancer cells.	Oxygen	77-83	TERF1 interacting nuclear factor 2	Homo sapiens	9-13
21981320-3	2011	As a consequence of the oxygen addition, the concentrations of hydroxycinnamic acid derivatives and flavan-3-ols decreased (above all t-GRP and (+)-catechin), leading to color stabilization, but also the concentrations of several volatile compounds with a great importance for quality aroma decreased.	Oxygen	24-30	gastrin releasing peptide	Homo sapiens	136-139
22907675-4	2012	The Sc-O bond in OScF consists of two covalent bonds and a dative bond in which the oxygen 2p(pi) lone pair donates electron density into an empty Sc 3d orbital thus forming a triple oxo bond.	Oxygen	84-90	DELYQ11	Homo sapiens	4-8
9402067-8	1997	These results indicate that gp120 is capable of promoting iron-based oxygen free radical damage to U937 cells.	Oxygen	69-75	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
22468883-2	2012	Hypoxia-inducible factor-1 (HIF-1) alpha-AA is a more stable mutant form of HIF-1alpha, which is a crucial oxygen-sensitive regulator.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	28-40
22468883-2	2012	Hypoxia-inducible factor-1 (HIF-1) alpha-AA is a more stable mutant form of HIF-1alpha, which is a crucial oxygen-sensitive regulator.	Oxygen	107-113	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	76-86
22081953-2	2011	OA consists of an intrafemoral reinfusion of autologous blood previously exposed to a mixture of oxygen/ozone (O2/O3).	Oxygen	97-103	immunoglobulin kappa variable 1D-39	Homo sapiens	111-116
22081953-5	2011	In addition, to evidence the possible protection induced by O2/O3 on endothelial functions, the present study analyzes the in vitro effects of O2/O3 on oxygen consumption by human umbilical vein endothelial cells (HUVEC).	Oxygen	152-158	immunoglobulin kappa variable 1D-39	Homo sapiens	143-148
9367531-3	1997	The reduced form of ceruloplasmin slowly reduced molecular oxygen to complete its catalytic cycle.	Oxygen	59-65	ceruloplasmin	Homo sapiens	20-33
21755341-11	2011	Treatment of the MDA-MB-231 cell line with DAC followed by hypoxia (0.1% O2) resulted in down-regulation of expression of the HIF-1alpha downstream genes VEGFA and SLC2A1 (P = 0.0029).	Oxygen	73-75	solute carrier family 2 member 1	Homo sapiens	164-170
22924385-3	2012	In this work, we utilize near-infrared off-axis integrated cavity output spectroscopy (off-axis ICOS) to quantify ambient oxygen with a precision (1sigma, 100s) of +-7 ppm.	Oxygen	122-128	inducible T cell costimulator	Homo sapiens	96-100
9357861-5	1997	Exposure of mice bearing the 2.5-kb PPET-1/LUC transgene to hypoxia (10% O2 for 24 h) increased LUC expression sixfold in pulmonary tissue but only twofold in other tissues.	Oxygen	73-75	endothelin 1	Mus musculus	36-42
21847517-9	2012	After adequate CPAP therapy, all FOSQ scores increased significantly (p &lt; 0.001) There were significant correlations between all FOSQ scores except sexual relationship and ESS (r -0.48); however, these had only a weak relationship with AHI and minimal oxygen saturation.	Oxygen	255-261	centromere protein J	Homo sapiens	15-19
21908554-6	2011	Moreover, CD8 T cells primed in this manner exhibited superior tumoricidal activity against target cells cultured in either atmospheric 20% O2 or physiologic 5% O2.	Oxygen	140-142	CD8a molecule	Homo sapiens	10-13
21908554-6	2011	Moreover, CD8 T cells primed in this manner exhibited superior tumoricidal activity against target cells cultured in either atmospheric 20% O2 or physiologic 5% O2.	Oxygen	161-163	CD8a molecule	Homo sapiens	10-13
22898032-1	2012	Prolyl hydroxylase domain 3 (PHD3) is a hypoxia inducible factor-alpha (HIFalpha) regulator; it degrades HIFalpha in the presence of oxygen.	Oxygen	133-139	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-27
21749921-6	2011	Here, we provided the first evidence that an oxygen and glucose deprivation episode can induce, in CA1 hippocampal slices, iLTP by modulation of the NO/cGMP/PKG pathway.	Oxygen	45-51	carbonic anhydrase 1	Homo sapiens	99-102
9357861-7	1997	These data are consistent with the hypothesis that hypoxic induction of the PPET-1 gene leads to increased pulmonary production of ET-1 in diseases associated with low O2 tension.	Oxygen	168-170	endothelin 1	Mus musculus	76-82
22898032-1	2012	Prolyl hydroxylase domain 3 (PHD3) is a hypoxia inducible factor-alpha (HIFalpha) regulator; it degrades HIFalpha in the presence of oxygen.	Oxygen	133-139	egl-9 family hypoxia inducible factor 3	Homo sapiens	29-33
9309676-5	1997	DHODH activity was determined by the dihydroorotate-dependent oxygen consumption or by the UV absorption of the product orotate with mitochondria isolated from rodent and porcine tissues.	Oxygen	62-68	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	0-5
22730195-7	2012	This preparation method leads to a properly balanced Ni/CNF catalyst in terms of Ni dispersion and hydrogenation capacity on the one hand, and the number of acidic surface-oxygen groups responsible for the acid-catalyzed hydrolysis on the other.	Oxygen	172-178	NPHS1 adhesion molecule, nephrin	Homo sapiens	56-59
21481060-5	2011	Oxygen tension had profound effects on basal placental cytokine levels as well as on IL-10-stimulated cytokine production.	Oxygen	0-6	interleukin 10	Homo sapiens	85-90
21481060-7	2011	Moreover, 21% O(2) levels increased the anti-inflammatory cytokines IL-10 and IL-13 while 1% O(2) tended to decrease the production of these cytokines.	Oxygen	14-18	interleukin 10	Homo sapiens	68-73
9244397-7	1997	Thus, although the myoglobin-promoted hydroxylation of linoleic acid into 11-hydroxylinoleic acid lacked apparent stereospecificity and produced equal amounts of the R and S enantiomers, the course of the reaction was stereospecific and involved hydrogen abstraction and oxygen insertion occurring with retention of absolute configuration of the carbon atom hydroxylated.	Oxygen	271-277	myoglobin	Homo sapiens	19-28
21442266-3	2011	After a baseline Arterial Blood Gas, all children received Oxygen via indigenous NB-CPAP Circuit which gave expiratory positive airway pressure of 5 cm water and delivered an FiO(2) of around 70%.	Oxygen	59-65	centromere protein J	Homo sapiens	84-88
21514373-3	2011	Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.	Oxygen	23-29	lysyl oxidase	Rattus norvegicus	172-175
22219589-3	2011	Methemoglobinemia is treated with supplemental oxygen and methylene blue (1-2 mg/kg) administered slow intravenously, which acts by providing an artificial electron acceptor for NADPH methemoglobin reductase.	Oxygen	47-53	hemoglobin subunit gamma 2	Homo sapiens	184-197
22534037-14	2012	Expression of the oxidoreductase thioredoxin (TRX1), the second major thiol-dependent antioxidant system in eukaryotic cells, was slightly reduced, while the oxygen-sensing protein HIF-1alpha was downregulated in HEMA-exposed cell cultures.	Oxygen	158-164	thioredoxin 1	Mus musculus	46-50
22609274-0	2012	The influence of triamcinolone on endostatin-like proteins in oxygen-induced retinopathy of prematurity.	Oxygen	62-68	collagen, type XVIII, alpha 1	Mus musculus	34-44
22609274-1	2012	In the murine model of oxygen-induced retinopathy of prematurity, early treatment (right after oxygen exposure) with triamcinolone reduced neovascularization and subsequently endostatin presence.	Oxygen	23-29	collagen, type XVIII, alpha 1	Mus musculus	175-185
22994058-0	2012	[The combined application of hypoxytherapy and oxygen therapy for the spa and resort-based treatment of bronchial asthma].	Oxygen	47-53	surfactant protein A2	Homo sapiens	70-73
22473746-3	2012	The ferrous complexes of these PEGylated porphyrins (PEG750-, PEG5k-, PEG10k- and PEG20k-hemoCDs) bound O(2) in aqueous solution, P(1/2) values being 6.5-8.1 Torr at pH 7.0 and 25  C. Each PEG(mw)-hemoCD was infused into the femoral vein of a Wistar male rat.	Oxygen	104-108	paternally expressed 10	Rattus norvegicus	70-75
21816440-0	2011	Preconditioning with hyperbaric oxygen induces tolerance against renal ischemia-reperfusion injury via increased expression of heme oxygenase-1.	Oxygen	32-38	heme oxygenase 1	Rattus norvegicus	127-143
9307123-0	1997	Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro.	Oxygen	78-84	carbonic anhydrase 1	Rattus norvegicus	116-119
21813652-8	2011	Compared with wild type (wt), the so2907 gene deletion (DeltaSO2907) mutant has impaired ability to reduce soluble Fe(III), but retains the same ability to respire oxygen or fumarate as the wt.	Oxygen	164-170	TonB-dependent receptor	Shewanella oneidensis MR-1	34-40
22524464-3	2012	The amplitude of the resistance change induced by H(2) exposure and the time rate of change of the nanowire resistance both increased with increasing temperature from 298 to 550 K. This resistance decrease of the Pt nanowire in the presence of H(2) results from reduced electron diffuse scattering at hydrogen-covered Pt surfaces as compared with oxygen-covered platinum surfaces, we hypothesize.	Oxygen	347-353	relaxin 2	Homo sapiens	244-248
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Oxygen	272-278	microRNA 15b	Homo sapiens	101-108
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	211-217
9202959-5	1997	In another series of experiments 85% O2-exposed cells, with or without U-74389G, were used for Northern blotting of gamma-GT mRNA.	Oxygen	37-39	gamma-glutamyltransferase 1	Rattus norvegicus	116-124
22752906-7	2012	The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.	Oxygen	89-95	catabolite gene activator protein	Escherichia coli	22-25
22044301-0	2012	Oxygen as a regulator of MA-10 cell functions: effect of cobalt chloride on vascular endothelial growth factor production.	Oxygen	0-6	vascular endothelial growth factor A	Mus musculus	76-110
21733843-6	2011	Crystallographic structures of Y271A- and wild type-substrate complexes indicated that rCTP is well accommodated in the active site but that O2" of rCTP and the carbonyl oxygen of Tyr-271 or Ala-271 are unusually close (~2.5 and 2.6 A, respectively).	Oxygen	141-143	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	148-152
9202959-6	1997	Exposure to 60% O2 decreased gamma-GT and GSH by -47 and -34%, respectively, while SOD and GPx activities remained unchanged.	Oxygen	16-18	gamma-glutamyltransferase 1	Rattus norvegicus	29-37
9202959-7	1997	After 85% O2-exposure gamma-GT decreased by -55%, SOD and GPx increased by +55 and +87%, respectively, while GSH decreased by -35%.	Oxygen	10-12	gamma-glutamyltransferase 1	Rattus norvegicus	22-30
21531396-6	2011	When borane is activated by Lewis acids, borane is the most electrophilic species that consequently coordinates to the most nucleophilic oxygen of the acetals, usually O-6.	Oxygen	137-143	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	168-171
9236909-0	1997	Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production.	Oxygen	132-134	interleukin 3	Homo sapiens	75-79
21499920-7	2011	Oxygen-induced defective vascular development correlated with a dramatic decrease in soluble guanylyl cyclase, phosphodiesterase (Pde) 4B and Pde4C mRNAs.	Oxygen	0-6	phosphodiesterase 4B, cAMP specific	Mus musculus	111-137
22327552-3	2012	RECENT FINDINGS: Accumulative increase in oxidative stress during ageing has been shown to decrease SIRT1 activity in catabolic tissue, possibly by direct inactivation by reactive oxygen.	Oxygen	180-186	sirtuin 1	Homo sapiens	100-105
22362590-5	2012	This model indicates that the steady state level of antiapoptotic neuroglobin is very sensitive to the cellular oxygen tension and moderately sensitive to the redox status of the cell.	Oxygen	112-118	neuroglobin	Homo sapiens	66-77
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	280-286	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	48-52
20447949-9	2011	Seven patients (7.8%) experienced a HSR requiring a treatment intervention (fluid bolus, oxygen, steroid, and/or diphenhydramine).	Oxygen	89-95	HSR	Homo sapiens	36-39
9169434-10	1997	These studies have also revealed that COX5a and CYC1, the genes for the aerobic isoforms of cytochrome c oxidase subunit V and cytochrome c, and COX5b and CYC7, the genes for the hypoxic isoforms of cytochrome c oxidase subunit V and cytochrome c, are coexpressed at a variety of oxygen concentrations and switch on or off at extremely low oxygen concentrations.	Oxygen	340-346	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	48-52
22670552-5	2012	This report presents such a case, in which a 52-year-old woman carrier of the BRCA2 mutation gene was successfully treated with hyperbaric oxygen therapy.	Oxygen	139-145	BRCA2 DNA repair associated	Homo sapiens	78-83
22613333-1	2012	BACKGROUND AND OBJECTIVE: The growth of tumor often faced up with lackness of blood and oxygen, and it has been reported that Annexin A1 may be involved in tumor.	Oxygen	88-94	annexin A1	Homo sapiens	126-136
21867964-1	2011	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Homo sapiens	0-11
21867964-1	2011	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Homo sapiens	13-16
9185246-5	1997	Pulmonary function improved by anti-L-selectin as represented by an increase of the arterio-venous oxygen ratio.	Oxygen	99-105	selectin L	Homo sapiens	36-46
21647537-6	2011	However, DCs differentiated under physiological oxygen level secreted higher levels of IL-12(p70) after exposure to LPS or CD40 ligand.	Oxygen	48-54	annexin A6	Homo sapiens	93-96
21647537-8	2011	In conclusion, we show that although DCs generated under atmospheric or physiological oxygen conditions are mostly similar in function and phenotype, DCs differentiated under physiological oxygen secrete larger amounts of IL-12(p70).	Oxygen	189-195	annexin A6	Homo sapiens	228-231
21647537-9	2011	This result could have implications for the use of ex vivo-generated DCs for clinical studies, since DCs differentiated at physiological oxygen could induce increased Th1 responses in vivo.	Oxygen	137-143	negative elongation factor complex member C/D	Homo sapiens	167-170
22451920-2	2012	We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustained and sufficient oxygen and nutrient exchange during fat mass expansion, thereby improving adipose tissue function.	Oxygen	97-103	vascular endothelial growth factor A	Mus musculus	21-27
22423973-3	2012	The presence of large amounts of singly ionized oxygen vacancies (V(O)(+)) is traced by photoluminescence spectroscopic analysis and they are found to be responsible for the observed ferromagnetism in pristine SnO(2) thin films.	Oxygen	48-54	strawberry notch homolog 2	Homo sapiens	210-213
22252129-4	2012	Either hypoxia or mutations in egl-9, a prolyl hydroxylase cellular oxygen sensor, result in the internalization of GLR-1, the reduction of glutamate-activated currents, and the depression of GLR-1-mediated behaviours.	Oxygen	68-74	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	31-36
9171333-12	1997	We conclude that expression of GPD2 is controlled by a novel, oxygen-independent, signalling pathway which is required to regulate metabolism under anoxic conditions.	Oxygen	62-68	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	31-35
22252129-6	2012	Instead, EGL-9 interacts with the Mint orthologue LIN-10, a mediator of GLR-1 membrane recycling, to promote LIN-10 subcellular localization in an oxygen-dependent manner.	Oxygen	147-153	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	9-14
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Oxygen	203-209	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	36-41
22252129-7	2012	The observed effects of hypoxia and egl-9 mutations require the activity of the proline-directed CDK-5 kinase and the CDK-5 phosphorylation sites on LIN-10, suggesting that EGL-9 and CDK-5 compete in an oxygen-dependent manner to regulate LIN-10 activity and thus GLR-1 trafficking.	Oxygen	203-209	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	173-178
22300373-1	2012	We studied the oxygen-induced restructuring process on a stepped Pt(557) single crystal surface using high-pressure scanning tunneling microscopy (HP-STM) and ambient-pressure X-ray photoelectron spectroscopy (AP-XPS) at O(2) pressures up to 1 Torr.	Oxygen	15-21	sulfotransferase family 1A member 3	Homo sapiens	150-153
21764444-10	2011	The TIMP2 concentration was increased only in 20% oxygen, but the mRNA level was decreased in 0.1% oxygen.	Oxygen	50-56	TIMP metallopeptidase inhibitor 2	Homo sapiens	4-9
21849555-0	2011	Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors.	Oxygen	0-6	carbonic anhydrase 3	Rattus norvegicus	89-92
9140021-5	1997	A single intraperitoneal dose of leptin increased oxygen consumption during the light cycle in ob/ob mice, ablating the circadian fluctuation in this parameter.	Oxygen	50-56	leptin	Mus musculus	33-39
21683784-5	2011	Abeta(25-35)-induced neuronal toxicity was inhibited by the overexpression of CypB as measured by cell viability, apoptotic morphology, sub-G1 cell population, intracellular reactive oxygen species accumulation, activated caspase-3, PARP cleavage, Bcl-2 proteins, mitogen-activated protein kinase (MAPK) activation, and phosphoinositide 3-kinase (PI-3-K) activation.	Oxygen	183-189	amyloid beta precursor protein	Rattus norvegicus	0-5
22300373-2	2012	HP-STM has revealed that nanometer-sized clusters are created on Pt(557) at 1 Torr of O(2) and at room temperature.	Oxygen	86-90	sulfotransferase family 1A member 3	Homo sapiens	3-6
22162090-0	2012	VEGF-independent cell-autonomous functions of HIF-1alpha regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.	Oxygen	68-74	vascular endothelial growth factor A	Mus musculus	0-4
22162090-10	2012	These findings suggest that HIF-1alpha activates VEGF-independent cell-autonomous mechanisms to sustain oxygen levels in the challenged avascular cartilage by reducing oxygen consumption.	Oxygen	104-110	vascular endothelial growth factor A	Mus musculus	49-53
22162090-10	2012	These findings suggest that HIF-1alpha activates VEGF-independent cell-autonomous mechanisms to sustain oxygen levels in the challenged avascular cartilage by reducing oxygen consumption.	Oxygen	168-174	vascular endothelial growth factor A	Mus musculus	49-53
22162090-12	2012	We conclude that VEGF and HIF-1alpha are critical preservers of chondrocyte survival by ensuring an adequate balance between availability and handling of oxygen in developing growth cartilage.	Oxygen	154-160	vascular endothelial growth factor A	Mus musculus	17-21
9100186-2	1997	During the entire procedure, cerebrovascular oxygen saturation (ScO2) was spectroscopically measured.	Oxygen	45-51	synthesis of cytochrome C oxidase 2	Homo sapiens	64-68
21676641-6	2012	The expression of Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 showed a significant increase in absence of oxygen, glucose and serum, especially in 72 h. Furthermore, the protein was found to translocate to mitochondria.	Oxygen	112-118	BCL2 interacting protein 3	Rattus norvegicus	18-67
21780918-8	2011	Semi-quantitative RT-PCR analysis showed that the putative limbal epithelial stem cell markers ABCG2 and p63alpha were expressed in 21%, 14%, and 8% oxygen, with a trend of lower expression in 8% oxygen being observed.	Oxygen	149-155	ATP-binding cassette sub-family G member 2	Oryctolagus cuniculus	95-100
21780918-8	2011	Semi-quantitative RT-PCR analysis showed that the putative limbal epithelial stem cell markers ABCG2 and p63alpha were expressed in 21%, 14%, and 8% oxygen, with a trend of lower expression in 8% oxygen being observed.	Oxygen	196-202	ATP-binding cassette sub-family G member 2	Oryctolagus cuniculus	95-100
9121557-0	1997	Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.	Oxygen	51-57	aryl hydrocarbon receptor nuclear translocator	Mus musculus	98-102
21664270-5	2011	This is an average rate of oxygen utilization of 2.5x10(-18) mol cell(-1) s(-1), i.e., 2.5 amol cell(-1) s(-1).	Oxygen	27-33	carboxyl ester lipase pseudogene	Homo sapiens	65-72
21664270-5	2011	This is an average rate of oxygen utilization of 2.5x10(-18) mol cell(-1) s(-1), i.e., 2.5 amol cell(-1) s(-1).	Oxygen	27-33	carboxyl ester lipase pseudogene	Homo sapiens	96-103
21664270-7	2011	Measured rates of oxygen utilization by mammalian cells in culture range from &lt;1 to &gt;350 amol cell(-1) s(-1).	Oxygen	18-24	carboxyl ester lipase pseudogene	Homo sapiens	100-107
21482645-8	2011	BRI treatment initiated during exposure to high oxygen significantly attenuated vitreoretinal VEGF concentrations, retinal vascular leakage, and retinal neovascularization in P17 mice subjected to oxygen-induced retinopathy.	Oxygen	48-54	vascular endothelial growth factor A	Mus musculus	94-98
21617180-7	2011	In addition, PLCdelta1(-/-) mice have a higher metabolic rate such as higher oxygen consumption and heat production.	Oxygen	77-83	phospholipase C, delta 1	Mus musculus	13-22
22082260-0	2012	Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.	Oxygen	12-18	small ubiquitin like modifier 3	Homo sapiens	58-63
25806068-6	2012	These results demonstrated that the NR3A gene can promote cell apoptosis and mediate the potential damage in the developing brain induced by exposure to non-physiologically high concentrations of oxygen.	Oxygen	196-202	glutamate receptor ionotropic, NMDA3A	Mus musculus	36-40
9121557-3	1997	In response to environmental pollutants, AHR-ARNT heterodimers regulate genes involved in the metabolism of xenobiotics, whereas ARNT-HIF-1alpha heterodimers probably regulate those involved in the response to oxygen deprivation.	Oxygen	210-216	aryl hydrocarbon receptor nuclear translocator	Mus musculus	129-133
22159995-3	2012	Although pannexin 1 has been shown to be the final conduit for ATP release from human erythrocytes in response to reduced oxygen tension, it does not participate in transport of ATP following stimulation of the prostacyclin (IP) receptor in these cells, which suggests that an additional protein must be involved.	Oxygen	122-128	pannexin 1	Homo sapiens	9-19
9121557-3	1997	In response to environmental pollutants, AHR-ARNT heterodimers regulate genes involved in the metabolism of xenobiotics, whereas ARNT-HIF-1alpha heterodimers probably regulate those involved in the response to oxygen deprivation.	Oxygen	210-216	hypoxia inducible factor 1, alpha subunit	Mus musculus	134-144
21421298-6	2011	The output organic fines were found to more biodegradable than the MSW input and SRF output samples in each of the test methods, significantly (p&lt;0.05) for the EHT and DR4 methods, on the basis of DOC released and oxygen consumed, respectively.	Oxygen	217-223	major histocompatibility complex, class II, DR beta 4	Homo sapiens	171-174
9113332-4	1997	In addition, an interaction site for the side-chain of Gln-165 in the human NK1 receptor that is probably involved in donating a hydrogen bond to the benzylamino nitrogen or benzylether oxygen of the quinuclidine and piperidine antagonists is explicitly postulated.	Oxygen	186-192	tachykinin receptor 1	Homo sapiens	76-88
21467031-4	2011	Here, we give evidence of a mechanism for the reverse reaction, namely dark reoxidation of protein-bound flavin in Arabidopsis thaliana cryptochrome (AtCRY1) by molecular oxygen that involves formation of a spin-correlated FADH( )-superoxide radical pair.	Oxygen	171-177	cryptochrome 1	Arabidopsis thaliana	150-156
22214851-0	2012	Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.	Oxygen	54-60	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	6-12
22214851-7	2012	Modulation of CHCHD4 protein expression in tumor cells regulated cellular oxygen consumption rate and metabolism.	Oxygen	74-80	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	14-20
9068641-5	1997	Under aerobic growth conditions, strains possessing ccoP and rdxB mutations both singly and in combination produced light-harvesting complexes, suggesting that normal functioning of these proteins is required to maintain repression of photosynthesis gene expression in the presence of oxygen.	Oxygen	285-291	cytochrome-c oxidase, cbb3-type subunit III	Rhodobacter sphaeroides 2.4.1	52-56
21791162-7	2012	GLUT1, G6PD and LDHA were up-regulated in cumulus cells that had been matured in low oxygen, suggesting a higher glucose uptake and an increase in anaerobic glycolysis, whereas cyclin B1 (CCNB) and MnSOD (Mn-superoxide dismutase) were upregulated in cumulus cells that had been matured in high oxygen, which suggests a higher activity of mitosis-promoting factor and antioxidant response.	Oxygen	85-91	solute carrier family 2 member 1	Homo sapiens	0-5
21791162-7	2012	GLUT1, G6PD and LDHA were up-regulated in cumulus cells that had been matured in low oxygen, suggesting a higher glucose uptake and an increase in anaerobic glycolysis, whereas cyclin B1 (CCNB) and MnSOD (Mn-superoxide dismutase) were upregulated in cumulus cells that had been matured in high oxygen, which suggests a higher activity of mitosis-promoting factor and antioxidant response.	Oxygen	294-300	solute carrier family 2 member 1	Homo sapiens	0-5
22846290-10	2012	In addition, there was less of an increase in oxidative stress, membrane damage and MMP-9 production at 6% O2 compared to21% O2.	Oxygen	107-109	matrix metallopeptidase 9	Homo sapiens	84-89
21491497-1	2011	Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid using gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide in absence of any cofactor or transition metal.	Oxygen	96-102	urate oxidase (pseudogene)	Homo sapiens	29-32
21491497-5	2011	In addition, both X-ray structure and quantum mechanic calculations promote a conserved base oxidative system as the main structural features in UOX that protonates/deprotonates and activate the substrate into the doublet state now able to satisfy the Wigner"s spin selection rule for reaction with molecular oxygen in its triplet ground state.	Oxygen	309-315	urate oxidase (pseudogene)	Homo sapiens	145-148
22846293-2	2012	In this study, the GOX/CAT system was used to independently provide and control the amount of H2O2 and oxygen in cell culture.	Oxygen	103-109	hydroxyacid oxidase 1	Homo sapiens	19-22
21460212-0	2011	Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels.	Oxygen	138-140	matrix metallopeptidase 9	Rattus norvegicus	0-32
9078278-7	1997	As a result of an analysis of structural models of the Ca2+-GD complex of PC, it is postulated that hydrogen bonds between the side chain of R15 and the functionally important Gla16 residue, as well as between the side chain of R15 and the carbonyl oxygen in the peptide bond of H10, are critical for adoption of a Ca2+-dependent conformation of the GD that allows functional phospholipid binding.	Oxygen	249-255	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	74-76
21460212-4	2011	In 1% O(2), levels of the hypoxia-inducible transcription factor HIF-1alpha were transiently increased.	Oxygen	6-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	65-75
21460212-7	2011	Specific inhibition of MMP-9 activity, verified using a fluorescent substrate assay, prevented the increase in proliferation and migration in 1% O(2).	Oxygen	145-149	matrix metallopeptidase 9	Rattus norvegicus	23-28
21460212-10	2011	Thus, MMP-9 is a key molecular effector, downstream of HIF-1alpha and Wnt activation, responsible for increased rates of NSC proliferation and migration in 1% O(2).	Oxygen	159-163	matrix metallopeptidase 9	Rattus norvegicus	6-11
22012955-0	2012	Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function.	Oxygen	0-6	nitric oxide synthase 3	Rattus norvegicus	69-73
22012955-14	2012	CONCLUSIONS: The results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression.	Oxygen	86-92	nitric oxide synthase 3	Rattus norvegicus	179-183
21535910-12	2012	The proapoptotic molecules BNIP3, BNIP3L, and Beclin-1 were all highly expressed, indicating exposure of islets to oxygen and nutrient deprivation during isolation.	Oxygen	115-121	beclin 1	Homo sapiens	46-54
21329748-4	2011	Recombinant PON1 pretreated animals exposed to sarin or soman prevented the reduction of blood O2 saturation and pulse rate observed after nerve agent exposure.	Oxygen	95-97	serum paraoxonase/arylesterase 1	Cavia porcellus	12-16
21362510-1	2011	Neuroglobin (Ngb), a recently found oxygen-binding protein belonging to the vertebrate globin family, is mainly expressed in neurons of brains and eyes.	Oxygen	36-42	neuroglobin	Homo sapiens	0-11
21362510-1	2011	Neuroglobin (Ngb), a recently found oxygen-binding protein belonging to the vertebrate globin family, is mainly expressed in neurons of brains and eyes.	Oxygen	36-42	neuroglobin	Homo sapiens	13-16
9032440-1	1997	Flavocytochrome b558 of the NADPH oxidase which generates superoxide in phagocytic cells, is a alpha1 beta1 heterodimer of gp91phox and p22phox, which together form a membrane-spanning electron-transport chain that transfers electrons from NADPH in the cytosol to oxygen.	Oxygen	264-270	cytochrome b-245 alpha chain	Homo sapiens	136-143
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Oxygen	156-164	germin-like protein 8-4	Triticum aestivum	0-15
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Oxygen	156-164	germin-like protein 8-4	Triticum aestivum	17-21
22563907-1	2012	Hb Johnstown [beta109(G11)Val Leu, GTG&gt;TTG] has previously been described as a high oxygen affinity variant in a heterozygous state and in combination with beta(0)-thalassemia (beta(0)-thal).	Oxygen	87-93	gamma-glutamyltransferase 1	Homo sapiens	35-38
22837676-3	2012	Neuroglobin (Ngb) is an oxygen-binding globin protein that is highly and specifically expressed in brain neurons.	Oxygen	24-30	neuroglobin	Homo sapiens	0-11
22837676-3	2012	Neuroglobin (Ngb) is an oxygen-binding globin protein that is highly and specifically expressed in brain neurons.	Oxygen	24-30	neuroglobin	Homo sapiens	13-16
9027711-10	1997	This demonstrates that oxygen shunt diffusion in the kidney cortex and medulla is a prerequisite for both the function of a sensor to measure pO2 and oxygen capacity to regulate erythropoietin secretion and to enable an effective adjustment of blood flow to the metabolic and functional demands of the kidney.	Oxygen	23-29	erythropoietin	Rattus norvegicus	178-192
20964692-6	2011	Low oxygen plays an important role for the induction of HYD1, HYDEF and HYDG, while ADH1 and HYD2 expression was relatively insensitive to oxygen availability.	Oxygen	4-10	uncharacterized protein	Chlamydomonas reinhardtii	56-60
9027711-10	1997	This demonstrates that oxygen shunt diffusion in the kidney cortex and medulla is a prerequisite for both the function of a sensor to measure pO2 and oxygen capacity to regulate erythropoietin secretion and to enable an effective adjustment of blood flow to the metabolic and functional demands of the kidney.	Oxygen	150-156	erythropoietin	Rattus norvegicus	178-192
22045484-0	2012	The BACE1-PSEN-AbetaPP regulatory axis has an ancient role in response to low oxygen/oxidative stress.	Oxygen	78-84	presenilin 1	Danio rerio	10-14
9027714-1	1997	Although a great deal of evidence supports the hypothesis that plasma erythropoietin (EPO) levels of mammals are related to the oxygen supply to the tissues relative to their oxygen needs, several observation millitate against its inherent simplicity.	Oxygen	128-134	erythropoietin	Mus musculus	70-84
9027714-1	1997	Although a great deal of evidence supports the hypothesis that plasma erythropoietin (EPO) levels of mammals are related to the oxygen supply to the tissues relative to their oxygen needs, several observation millitate against its inherent simplicity.	Oxygen	128-134	erythropoietin	Mus musculus	86-89
22731388-3	2012	The syn oxygen atom of the carboxylic group attacks the alpha-phosphorous atom (alphaP) of ATP in all class I aaRSs (except TrpRS) investigated, while the anti oxygen atom attacks in the case of class II aaRSs.	Oxygen	8-14	synemin	Homo sapiens	4-7
21507302-6	2011	RESULTS: The apoptosis rate of AECIIincreased, the percentages of G2/M and S phase cells decreased and the protein levels of PCNA decreased significantly in the group exposed to 95%O2/5%CO2 compared with the group exposed to air (P&lt;0.01).	Oxygen	181-183	proliferating cell nuclear antigen	Rattus norvegicus	125-129
9027714-1	1997	Although a great deal of evidence supports the hypothesis that plasma erythropoietin (EPO) levels of mammals are related to the oxygen supply to the tissues relative to their oxygen needs, several observation millitate against its inherent simplicity.	Oxygen	175-181	erythropoietin	Mus musculus	70-84
22731388-3	2012	The syn oxygen atom of the carboxylic group attacks the alpha-phosphorous atom (alphaP) of ATP in all class I aaRSs (except TrpRS) investigated, while the anti oxygen atom attacks in the case of class II aaRSs.	Oxygen	160-166	synemin	Homo sapiens	4-7
22731388-6	2012	The result shows that the strength of the interaction of syn oxygen and alphaP is stronger than the interaction with the anti oxygen for class I aaRSs.	Oxygen	61-67	synemin	Homo sapiens	57-60
9027714-1	1997	Although a great deal of evidence supports the hypothesis that plasma erythropoietin (EPO) levels of mammals are related to the oxygen supply to the tissues relative to their oxygen needs, several observation millitate against its inherent simplicity.	Oxygen	175-181	erythropoietin	Mus musculus	86-89
22731388-7	2012	This indicates that the syn oxygen is the most probable candidate for the nucleophilic attack in class I aaRSs.	Oxygen	28-34	synemin	Homo sapiens	24-27
9386988-0	1997	Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina.	Oxygen	116-122	vascular endothelial growth factor A	Rattus norvegicus	13-47
22731388-8	2012	The result is further supported by the computation of the variation of the nonbonded interaction energies between alphaP atom and anti oxygen as well as syn oxygen in class I and II aaRSs, respectively.	Oxygen	157-163	synemin	Homo sapiens	153-156
21406103-5	2011	RESULTS: We aimed to manipulate oxygen stress perception in Arabidopsis seeds by overexpression of the non-symbiotic hemoglobin AtHb1 under the control of the seed-specific LeB4 promoter.	Oxygen	32-38	hemoglobin 1	Arabidopsis thaliana	128-133
9386988-0	1997	Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina.	Oxygen	116-122	vascular endothelial growth factor A	Rattus norvegicus	49-53
23233787-0	2012	Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression.	Oxygen	24-30	vascular endothelial growth factor A	Mus musculus	133-169
9386988-9	1997	There was also a pan-retinal distribution of non-endothelial cells that were VEGF-positive in both room air and oxygen-injured rats, with stronger immunostaining in day 16 oxygen-injured retinas.	Oxygen	112-118	vascular endothelial growth factor A	Rattus norvegicus	77-81
23094087-3	2012	We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to oxygen/glucose deprivation, and in mice exposed to middle cerebral artery occlusion.	Oxygen	158-164	ubiquitin-conjugating enzyme E2I	Mus musculus	42-46
20463290-3	2011	The aim of this study was to determine the role of CD44 during hyperoxia-induced (&gt; 95% oxygen) acute lung injury.	Oxygen	91-97	CD44 antigen	Mus musculus	51-55
21542347-2	2011	The effect of Ca2+ on the oxygen absorption rate has been studied, and a kinetic model has been suggested, which takes different stages of interaction of pyrocatechol and its radical form with oxygen into account.	Oxygen	26-32	carbonic anhydrase 2	Homo sapiens	14-17
21542347-2	2011	The effect of Ca2+ on the oxygen absorption rate has been studied, and a kinetic model has been suggested, which takes different stages of interaction of pyrocatechol and its radical form with oxygen into account.	Oxygen	193-199	carbonic anhydrase 2	Homo sapiens	14-17
23056199-2	2012	This study shows direct evidence for an intramolecular hydrogen bond between the reducing ring HO3 hydroxyl group and the non-reducing ring oxygen (O5") that has been previously predicted by computation and NMR analysis.	Oxygen	140-146	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-98
9386988-13	1997	The production of VEGF by these cells--in particular, Muller cells--may promote preretinal neovascularization in oxygen-injured eyes.	Oxygen	113-119	vascular endothelial growth factor A	Rattus norvegicus	18-22
23056199-3	2012	Moreover, this work shows that hydrogen bonding to the non-reducing ring O5" oxygen is shared between water and the HO3 hydroxyl group with an average of 50% occupancy by each hydrogen-bond donor.	Oxygen	77-83	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	116-119
9352384-10	1997	Ethane 1-hydroxy-1, 1-bisphosphonate counteracted the effect of uranyl nitrate on oxygen-dependent and cobalt-dependent erythropoietin production, but did not correct the right shift of the dose-response relationship for exogenous erythropoietin induced by uranyl nitrate in the polycythemic rat.	Oxygen	82-88	erythropoietin	Rattus norvegicus	120-134
22299048-3	2012	Both are regulated by oxygen dependent degradation, which is controlled by the tumor suppressor "von Hippel-Lindau" (VHL), the gatekeeper of renal tubular growth control.	Oxygen	22-28	von Hippel-Lindau tumor suppressor	Mus musculus	117-120
21276671-0	2011	Early weaning from CPAP to high flow nasal cannula in preterm infants is associated with prolonged oxygen requirement: a randomized controlled trial.	Oxygen	99-105	centromere protein J	Homo sapiens	19-23
9037646-9	1997	The relationship between mesenteric oxygen delivery (DO2ms) and pHi during acute ischemia is best described by a sigmoid curve.	Oxygen	36-42	vasoactive intestinal peptide	Sus scrofa	64-67
21123494-9	2011	However, 40% O(2) induced substantially greater total beta- and gamma-ENaC on the apical surface compared with 8% O(2); both subunits demonstrated a greater increase in the mature forms.	Oxygen	13-17	sodium channel epithelial 1 subunit gamma	Homo sapiens	64-74
21921827-8	2012	In contrast, intermittent 100% oxygen exerted favorable effects on markers of inflammation, attenuated leukocyte expression of L selectin and CD11 (P &lt; 0.01), decreased pulmonary sequestration of leukocytes (P &lt; 0.001), and ameliorated changes in macromolecular leak (P &lt; 0.01) and lung solid tissue area (P &lt; 0.05).	Oxygen	31-37	selectin L	Rattus norvegicus	127-137
9037646-10	1997	There was a linear correlation between the changes of the jejunal surface oxygen tensions and pHi due to SMA flow reduction.	Oxygen	74-80	vasoactive intestinal peptide	Sus scrofa	94-97
21183487-4	2011	We show that (i) gamma oscillation power, oxygen consumption and expression of complex I (nicotinamide adenine dinucleotide:ubiquinone oxidoreductase) subunits are higher in hippocampal subfield CA3 than in CA1 and dentate gyrus; (ii) the amount of oxygen consumption of gamma oscillations reaches that of seizure-like events; (iii) gamma oscillations are exquisitely sensitive to pharmacological complex I inhibition; and (iv) gamma oscillations utilize mitochondrial oxidative capacity near limit.	Oxygen	249-255	carbonic anhydrase 3	Rattus norvegicus	195-198
9037646-11	1997	CONCLUSION: The sigmoid relationship between pHi and DO2ms indicated that pHi is a sensitive parameter for detecting ischemia at 50% of the baseline oxygen delivery and that below 25% there was no further decrease of pHi.	Oxygen	149-155	vasoactive intestinal peptide	Sus scrofa	74-77
23109569-6	2012	Average removal rates of water quality parameters by the DAF-MBR system were very high, e.g. COD(cr) 95.88%, BOD5 99.66%, COD(mn) (chemical oxygen demand by Mn) 93.63%, T-N 69.75%, NH4-N 98.46%, T-P 78.23%, and SS 99.51%, which satisfy effluent water quality standards.	Oxygen	140-146	translocator protein	Homo sapiens	61-64
9037646-11	1997	CONCLUSION: The sigmoid relationship between pHi and DO2ms indicated that pHi is a sensitive parameter for detecting ischemia at 50% of the baseline oxygen delivery and that below 25% there was no further decrease of pHi.	Oxygen	149-155	vasoactive intestinal peptide	Sus scrofa	74-77
9157386-7	1997	Myoglobin washing into plasma occurs under all temperature conditions of perfusion at the warming-up stages and in the early postperfusion period, but it is most profound in deeper hypothermia, which is caused by the toxic effect of oxygen whose plasma solubility increases with lowered temperatures.	Oxygen	233-239	myoglobin	Homo sapiens	0-9
21964540-1	2011	Hydrogen peroxide triggers a redox cycle between methemoglobin and ferrylhemoglobin, leading to protein inactivation and oxygen evolution.	Oxygen	121-127	hemoglobin subunit gamma 2	Homo sapiens	49-62
21964540-2	2011	In the present paper, the catalase-like oxygen production by human methemoglobin in the presence of H(2)O(2) was kinetically characterized with a Clark-type electrode.	Oxygen	40-46	hemoglobin subunit gamma 2	Homo sapiens	67-80
21268161-0	2011	Spin-trapping evidence for the formation of alkyl, alkoxyl, and alkylperoxyl radicals in the reactions of dialkylzincs with oxygen.	Oxygen	124-130	spindlin 1	Homo sapiens	0-4
21268161-1	2011	The reactions of dialkylzincs (Me(2)Zn, Et(2)Zn, and nBu(2)Zn) with oxygen have been investigated by EPR spectroscopy using spin-trapping techniques.	Oxygen	68-74	spindlin 1	Homo sapiens	124-128
21268161-5	2011	When the dialkylzincs were used in excess with respect to the spin-trap, the concentration of the oxygen-centered radical adducts of DEPMPO was much lower for Et(2)Zn and nBu(2)Zn than for Me(2)Zn.	Oxygen	98-104	spindlin 1	Homo sapiens	62-66
8941338-1	1996	The reactivity of rabbit reticulocyte 15-lipoxygenase (15-LOX) with phosphatidylcholine (PC) possessing linoleic acid (LA-PC), arachidonic acid (AA-PC), or docosahexaenoic acid (DHA-PC) was investigated by measuring oxygen uptake in the suspension of large unilamellar liposomes (LUV).	Oxygen	44-50	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	55-61
21094578-7	2011	CONCLUSIONS: Hypoxia regulates adrenomedullin secretion and expression by human placenta, thereby promoting increased adrenomedullin concentration in the fetal circulation in clinical circumstances characterized by reduced oxygen levels.	Oxygen	223-229	adrenomedullin	Homo sapiens	31-45
25212296-6	2011	Thus, during heating, provided PPO remained active with enough available O2 in the model systems, CG oxidation and coupled oxidoreduction with AA could readily develop.	Oxygen	73-75	polyphenol oxidase, chloroplastic	Malus domestica	31-34
8917565-2	1996	Based on the observation that NEB cells have a candidate oxygen sensor enzyme complex (NADPH oxidase) and an oxygen-sensitive K+ current, it has been suggested that NEB may function as airway chemoreceptors.	Oxygen	57-63	NADPH oxidase 1	Oryctolagus cuniculus	87-100
21846809-6	2011	Gclc mRNA was significantly elevated in embryos cultured in Whitten"s medium compared with embryos cultured in KSOMaa, and Gclc mRNA was elevated under high-oxygen conditions.	Oxygen	157-163	glutamate-cysteine ligase, catalytic subunit	Mus musculus	0-4
21846809-6	2011	Gclc mRNA was significantly elevated in embryos cultured in Whitten"s medium compared with embryos cultured in KSOMaa, and Gclc mRNA was elevated under high-oxygen conditions.	Oxygen	157-163	glutamate-cysteine ligase, catalytic subunit	Mus musculus	123-127
21737784-3	2011	METHODS AND RESULTS: In a model of oxygen-induced retinopathy, Bmper mRNA expression and protein levels are downregulated, correlating with the initiation of Sma and Mad related protein phosphorylation in endothelial cells.	Oxygen	35-41	BMP-binding endothelial regulator	Mus musculus	63-68
21711378-3	2011	In the present study, we investigated the protective role of HO-1 in hyperbaric oxygen (HBO) preconditioning against liver injury after I/R.	Oxygen	80-86	heme oxygenase 1	Rattus norvegicus	61-65
21194630-1	2011	Heme oxygenase (HO) catalyses the degradation of heme to biliverdin, carbon monoxide (CO) and ferrous iron via three successive monooxygenase reactions, using electrons provided by NADPH-cytochrome P450 reductase (CPR) and oxygen molecules.	Oxygen	5-11	cytochrome p450 oxidoreductase	Rattus norvegicus	181-212
21194630-1	2011	Heme oxygenase (HO) catalyses the degradation of heme to biliverdin, carbon monoxide (CO) and ferrous iron via three successive monooxygenase reactions, using electrons provided by NADPH-cytochrome P450 reductase (CPR) and oxygen molecules.	Oxygen	5-11	cytochrome p450 oxidoreductase	Rattus norvegicus	214-217
21194630-7	2011	Under physiological conditions, therefore, it is possible that O(2) initially binds to the ferrous iron of alpha-verdoheme in its complex with HO-1 and an electron is subsequently transferred from CPR, probably via FAD, to the oxaporphyrin ring.	Oxygen	63-67	cytochrome p450 oxidoreductase	Rattus norvegicus	197-200
21185900-4	2011	Here we show in cultured astrocytes that the suppression of the activity of P2X(7)Rs during simulated ischemia (oxygen/glucose deprivation, OGD) resulted in the opening of Px1 hemichannels, leading to the enhanced release of ATP.	Oxygen	112-118	pannexin 1	Homo sapiens	172-175
21205613-7	2011	On the other hand, the combined deletion of HPR1, HPR2, and HPR3 causes increased growth retardation, decreased photochemical efficiency, and reduced oxygen-dependent gas exchange in comparison with the hpr1xhpr2 double mutant.	Oxygen	150-156	D-isomer specific 2-hydroxyacid dehydrogenase family protein	Arabidopsis thaliana	60-64
8795231-11	1996	Severe oxygen limitation, in contrast, resulted in poor lipase productivity despite effective induction of the ANR-dependent promoter, suggesting that secretion of active lipase is blocked by the absence of oxygen.	Oxygen	7-13	lipase	Pseudomonas aeruginosa PAO1	56-62
21266088-8	2011	Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function.	Oxygen	206-212	arginyl aminopeptidase	Homo sapiens	12-15
21266088-12	2011	CONCLUSIONS: This study allows the discovery of new boron-oxygen core containing compounds with the same ability as 2-APB to both potentiate and inhibit the SOCE of different leukocyte cell lines.	Oxygen	58-64	arginyl aminopeptidase	Homo sapiens	118-121
21704147-1	2011	Tissue hypoxia leads to activation of endogenous adaptive responses that involve a family of prolyl hydroxylase domain proteins (PHD1-3) with oxygen sensing properties, hypoxia inducible transcription factors (HIFs), and cytoprotective HIF target genes such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF).	Oxygen	142-148	egl-9 family hypoxia-inducible factor 2	Mus musculus	129-133
21977017-6	2011	Phox2b(+/-) pups also showed lower oxygen consumption (VO(2)) in the cold, reflecting reduced thermogenesis and a lower body temperature.	Oxygen	35-41	paired-like homeobox 2b	Mus musculus	0-6
8795231-11	1996	Severe oxygen limitation, in contrast, resulted in poor lipase productivity despite effective induction of the ANR-dependent promoter, suggesting that secretion of active lipase is blocked by the absence of oxygen.	Oxygen	7-13	lipase	Pseudomonas aeruginosa PAO1	171-177
8795231-11	1996	Severe oxygen limitation, in contrast, resulted in poor lipase productivity despite effective induction of the ANR-dependent promoter, suggesting that secretion of active lipase is blocked by the absence of oxygen.	Oxygen	207-213	lipase	Pseudomonas aeruginosa PAO1	171-177
21075090-3	2011	This study highlights the anti-apoptotic effects of the drug, which are mediated by specific regulation of apoptosis-inducing factor (AIF) in the process of oxygen and glucose deprivation (OGD)-induced apoptosis in SH-SY5Y cells.	Oxygen	157-163	apoptosis inducing factor mitochondria associated 1	Homo sapiens	107-132
21075090-3	2011	This study highlights the anti-apoptotic effects of the drug, which are mediated by specific regulation of apoptosis-inducing factor (AIF) in the process of oxygen and glucose deprivation (OGD)-induced apoptosis in SH-SY5Y cells.	Oxygen	157-163	apoptosis inducing factor mitochondria associated 1	Homo sapiens	134-137
8910864-2	1996	At a molar ratio (drug:protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%.	Oxygen	55-61	myoglobin	Homo sapiens	172-181
21728233-2	2011	For the GOx assay, the postulated fluorescence mechanism is based on the consumption of glucose by dissolved oxygen and GOx in the microwell plates covered with the PSU-Py membrane.	Oxygen	109-115	hydroxyacid oxidase 1	Homo sapiens	8-11
8876037-4	1996	Obviously, the amino group of the amide part is more important than the oxygene atom of the carbonyl group, as NPY 1-35-tyrosinol has a lower affinity than NPY 1-35-tyrosinethioamide.	Oxygen	72-79	neuropeptide Y	Homo sapiens	111-114
21698390-9	2011	The alterations in substrate transport were accompanied by parallel changes in transporter gene expression, GLUT1 and MCT1 mRNA level increasing from 15% and 10% O2, respectively.	Oxygen	162-164	solute carrier family 2 member 1	Homo sapiens	108-113
21617579-8	2011	We observed that 100% oxygen treatment prevented the abnormal changes in organ histopathology, lactate dehydrogenase and C-reactive protein in serum, inflammatory cytokines in serum and tissue, and arterial blood gas analysis and improved the survival rate in zymosan-challenged mice.	Oxygen	22-28	C-reactive protein, pentraxin-related	Mus musculus	121-139
21675192-5	2011	A significant increase in glucose-6-phosphate dehydrogenase and superoxide dismutase activities against reduction of catalase activity points to both reparative processes in erythrocytes and disbalance between the number of evolving active forms of oxygen and antioxidant protection mechanisms in cells.	Oxygen	249-255	glucose-6-phosphate dehydrogenase	Homo sapiens	26-59
20671746-0	2011	Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression.	Oxygen	9-15	cyclin-dependent kinase inhibitor 1B	Mus musculus	133-140
8765226-3	1996	This paper discusses the evidence that, in the presence of argon and in oxygen-free experimental environment, the reduced horse heart cytochrome c, instead of undergoing a denaturation process, is oxidized to ferric-cytochrome c.	Oxygen	72-78	cytochrome c, somatic	Equus caballus	134-146
21785006-8	2011	Knockdown of PHD3 decreases glucose transporter 1, lactate dehydrogenase A, and pyruvate dehydrogenase kinase 1 expression; decreases glucose uptake and lactate production; and increases O(2) consumption.	Oxygen	187-191	egl-9 family hypoxia inducible factor 3	Homo sapiens	13-17
21146880-8	2011	Western blot analysis showed that miR-15a inhibited endogenous UCP-2 protein levels, and resulted in the increase in oxygen consumption and reduced ATP generation.	Oxygen	117-123	microRNA 15a	Mus musculus	34-41
21652295-3	2011	We aimed first to evaluate the effect of normobaric, systemic hypoxia (11% O2) on HIF-1alpha and VEGF mRNA levels in the heart muscle; secondly, to compare the levels of HIF-1alpha and VEGF mRNA in the left and right ventricle muscles.	Oxygen	75-77	vascular endothelial growth factor A	Oryctolagus cuniculus	97-101
21652295-10	2011	CONCLUSION: Since systemic hypoxia results in induction of VEGF mRNA up-regulation only in left ventricle, it could be related to its higher metabolic activity and oxygen utilization.	Oxygen	164-170	vascular endothelial growth factor A	Oryctolagus cuniculus	59-63
21069338-3	2011	SSAT1 has been reported to bind to HIF-1alpha and RACK1, resulting in oxygen-independent HIF-1 ubiquitination and degradation.	Oxygen	70-76	receptor for activated C kinase 1	Homo sapiens	50-55
21069338-4	2011	SSAT2, a related protein, stabilizes the interaction of the VHL protein and elongin C with HIF-1 leading to oxygen-dependent HIF-1alpha ubiquitination and degradation.	Oxygen	108-114	elongin C	Homo sapiens	76-85
21565854-8	2011	In addition, levels of oxygen consumption and brown adipose tissue uncoupling protein 1 were significantly elevated with POMC treatment in the VTA.	Oxygen	23-29	proopiomelanocortin	Rattus norvegicus	121-125
21971004-1	2011	In Parkinson"s disease, type B monoamine oxidase (MAO-B) is proposed to play an important role in the pathogenesis through production of reactive oxygen species and neurotoxins from protoxicants, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	Oxygen	146-152	monoamine oxidase B	Homo sapiens	50-55
21971006-3	2011	It has been demonstrated to be neuroprotective in PD model systems by preventing the formation of reactive oxygen species derived from prevention of derived from oxidation of dopamine by MAO-B and via an antiapoptotic action, which appears to be independent of MAO-B inhibition and related to its embedded N-propargyl moiety.	Oxygen	107-113	monoamine oxidase B	Homo sapiens	187-192
8765226-3	1996	This paper discusses the evidence that, in the presence of argon and in oxygen-free experimental environment, the reduced horse heart cytochrome c, instead of undergoing a denaturation process, is oxidized to ferric-cytochrome c.	Oxygen	72-78	cytochrome c, somatic	Equus caballus	216-228
21707036-4	2011	This result indicates that the hydrophilic core group is anchored to ions in the water via bidentate chelates with the carboxylate oxygen atoms of G1 and G2.	Oxygen	131-137	proline rich protein BstNI subfamily 3	Homo sapiens	147-156
8707871-7	1996	Taken together, these findings suggest that a classic heme protein and a related oxygen-dependent production of oxygen radicals is less likely to be involved in the regulation of the EPO gene by oxygen in hepatocytes.	Oxygen	81-87	erythropoietin	Rattus norvegicus	183-186
21671682-3	2011	Sulfidefluor-1 (SF1) and Sulfidefluor-2 (SF2) respond to H(2)S by a turn-on fluorescence signal enhancement and display high selectivity for H(2)S over other biologically relevant reactive sulfur, oxygen, and nitrogen species.	Oxygen	197-203	splicing factor 1	Homo sapiens	16-19
22016779-1	2011	We have previously shown that a massive increase in global SUMOylation occurs during torpor in ground squirrels, and that overexpression of Ubc9 and/or SUMO-1 in cell lines and cortical neurons protects against oxygen and glucose deprivation.	Oxygen	211-217	ubiquitin-conjugating enzyme E2I	Mus musculus	140-144
21671682-3	2011	Sulfidefluor-1 (SF1) and Sulfidefluor-2 (SF2) respond to H(2)S by a turn-on fluorescence signal enhancement and display high selectivity for H(2)S over other biologically relevant reactive sulfur, oxygen, and nitrogen species.	Oxygen	197-203	serine and arginine rich splicing factor 1	Homo sapiens	41-44
8707871-7	1996	Taken together, these findings suggest that a classic heme protein and a related oxygen-dependent production of oxygen radicals is less likely to be involved in the regulation of the EPO gene by oxygen in hepatocytes.	Oxygen	112-118	erythropoietin	Rattus norvegicus	183-186
8674235-2	1996	It has been suggested that a conformational change in beta 2-GPI, induced by binding either to anionic phospholipids or to the oxygen molecules on the irradiated microtiter plate, reveals cryptic antigenic epitope(s) in the native protein.	Oxygen	127-133	apolipoprotein H	Homo sapiens	54-64
21515660-8	2011	Overnight (24 h) exposure of ASM cells to 50% oxygen increased BDNF and TrkB expression and potentiated both SP- and BDNF-induced enhancement of [Ca(2+)](i) (P &lt; 0.05).	Oxygen	46-52	brain derived neurotrophic factor	Homo sapiens	63-67
21515660-8	2011	Overnight (24 h) exposure of ASM cells to 50% oxygen increased BDNF and TrkB expression and potentiated both SP- and BDNF-induced enhancement of [Ca(2+)](i) (P &lt; 0.05).	Oxygen	46-52	brain derived neurotrophic factor	Homo sapiens	117-121
21133400-5	2010	Oxygen vacancies are unambiguously located on the 4c site ({CuO(2)} plane) for compositions with different strontium contents, which electronic state is described by the O 2p core electron peak at about 531 eV.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	170-174
20967313-4	2010	Moreover, our simulation results suggest that the experimentally observed complex UO(2)(NO(3))(2) 2TBP is formed after the migration of the aforementioned complexes into the organic phase by means of a reorganization of the nitrate binding mode from mono to bidentate which removes the excess oxygen atoms bound to uranyl.	Oxygen	293-299	TATA-box binding protein	Homo sapiens	99-102
8756971-0	1996	Dead Sea: natural oxygen enrichment at low altitude.	Oxygen	18-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	5-8
20497028-5	2010	Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK).	Oxygen	11-13	annexin A6	Homo sapiens	156-159
22491306-7	2010	The modeled structure of CYP2C19 showed that the hydrogen bond between the main chain oxygen of Ile207 and the side chain Ogamma of Thr210 would be lost when Thr210 was substituted by Asn; however, no steric constraint was observed, although Asn is larger than Thr in size.	Oxygen	86-92	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	25-32
20923209-7	2010	Rather, the Cl2 rapidly reacts with the solid TiO2 to form TiCl4 and O2.	Oxygen	48-50	endogenous retrovirus group W member 5	Homo sapiens	12-15
20841412-1	2010	BACKGROUND: Methemoglobin in the blood cannot be detected by conventional pulse oximetry and may bias the oximeter"s estimate (Spo(2)) of the true arterial functional oxygen saturation (Sao(2)).	Oxygen	167-173	hemoglobin subunit gamma 2	Homo sapiens	12-25
20841412-12	2010	CONCLUSIONS: The Rainbow"s methemoglobin readings are acceptably accurate over an oxygen saturation range of 74%-100% and a methemoglobin range of 0%-14%.	Oxygen	82-88	hemoglobin subunit gamma 2	Homo sapiens	27-40
20467833-1	2010	Superoxide dismutase (SOD) catalyzes the dismutation of the biologically toxic superoxide anion into oxygen and hydrogen peroxide and is deployed by the immune system to kill invading microorganisms.	Oxygen	101-107	superoxide dismutase 3	Rattus norvegicus	22-25
20637183-5	2010	PlGF expression and release from brain microvascular endothelial cells (BMECs) in response to oxygen and glucose deprivation (OGD) were examined in primary culture.	Oxygen	94-100	placental growth factor	Rattus norvegicus	0-4
20967268-7	2010	UCP2 accounted for a remarkable 37% of the resting cellular oxygen consumption indicating that the MX2 cells are functionally reliant on this protein.	Oxygen	60-66	MX dynamin like GTPase 2	Homo sapiens	99-102
20601226-10	2010	The 3D model of the catalytic domain of rat DPP III showed that the carboxyl oxygen atoms of Glu507 and Glu512 form the hydrogen bonds to the nitrogen atoms of His455 and His450.	Oxygen	77-83	dipeptidylpeptidase 3	Rattus norvegicus	44-51
20930593-3	2010	AM also suppressed the production of oxygen-free radicals.	Oxygen	37-43	adrenomedullin	Homo sapiens	0-2
20600837-4	2010	UCP5 overexpression increased proton leak, decreased mitochondrial membrane potential (MMP), reduced ATP production, and increased overall oxygen consumption (demonstrating uncoupling activity).	Oxygen	139-145	solute carrier family 25 member 14	Homo sapiens	0-4
20496369-5	2010	Oxygen-dependent changes in ANK expression in nucleus pulposus cells were minimal.	Oxygen	0-6	ankyrin 1	Homo sapiens	28-31
20694792-0	2010	Oxygen/ozone protects the heart from acute myocardial infarction through local increase of eNOS activity and endothelial progenitor cells recruitment.	Oxygen	0-6	nitric oxide synthase 3	Rattus norvegicus	91-95
20694792-1	2010	The purpose of this study is to investigate whether an oxygen/ozone (O(2)/O(3)) mixture protects the heart from acute myocardial infarction through local involvement of endothelial nitric oxide synthase (eNOS) and endothelial progenitor cells (EPCs).	Oxygen	55-61	nitric oxide synthase 3	Rattus norvegicus	204-208
20694792-1	2010	The purpose of this study is to investigate whether an oxygen/ozone (O(2)/O(3)) mixture protects the heart from acute myocardial infarction through local involvement of endothelial nitric oxide synthase (eNOS) and endothelial progenitor cells (EPCs).	Oxygen	69-73	nitric oxide synthase 3	Rattus norvegicus	204-208
20694792-14	2010	O(2)/O(3) mixture protects the heart from acute myocardial infarction through local increase of eNOS expression/activity and consequent EPCs recruitment.	Oxygen	0-4	nitric oxide synthase 3	Rattus norvegicus	96-100
20637647-10	2010	Gene analysis revealed a significant transient and dose dependent change in expression of RBOHC indicating active reactive oxygen production induced by gamma irradiation.	Oxygen	123-129	NADPH/respiratory burst oxidase protein D	Arabidopsis thaliana	90-95
21061603-2	2010	The concentration of O2-, H2O2, and activity of oxidoreductases (oxalate oxidase, peroxidase, and catalase) depends on the content of Ca2+ ions in the culture medium of calluses.	Oxygen	21-23	germin-like protein 8-4	Triticum aestivum	65-80
20796307-7	2010	RESULTS: Compared to air-oxygen, helium-oxygen significantly decreased VCO2 production at the end of the 2 hour period of CPAP ventilation; there was a mean difference in CO2 production of 48.9 ml/min (95% CI 18.7-79.2 p = 0.003) between the groups.	Oxygen	40-46	centromere protein J	Homo sapiens	122-126
20675541-1	2010	Myoglobin (Mb) is an important intracellular oxygen-binding hemoprotein found in the cytoplasm of skeletal and cardiac muscle tissue playing a well-known role in O(2) storage and delivery.	Oxygen	162-166	myoglobin	Mus musculus	0-9
20675541-1	2010	Myoglobin (Mb) is an important intracellular oxygen-binding hemoprotein found in the cytoplasm of skeletal and cardiac muscle tissue playing a well-known role in O(2) storage and delivery.	Oxygen	162-166	myoglobin	Mus musculus	11-13
20679826-1	2010	BACKGROUND: Hyperbaric oxygen decreases ischemia-reperfusion-induced neutrophil/intercellular adhesion molecule-1 adhesion by blocking CD18 polarization.	Oxygen	23-29	intercellular adhesion molecule 1	Rattus norvegicus	80-113
20679826-14	2010	CONCLUSION: These results suggest that the hyperbaric oxygen reduction of ischemia-reperfusion-induced neutrophil polarization of CD18 and adherence to intercellular adhesion molecule-1 is mediated through a nitric oxide mechanism that requires nitric oxide synthase.	Oxygen	54-60	intercellular adhesion molecule 1	Rattus norvegicus	152-185
20558139-6	2010	Treatment of Huh7 cells with kaempferol under hypoxic conditions (1% oxygen) effectively inhibited HIF-1 activity in a dose-dependent manner (IC(50)=5.16microM).	Oxygen	69-75	MIR7-3 host gene	Homo sapiens	13-17
19500819-3	2010	Oxygen insensitivity of the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) activity is a diagnostic tool for the detection of carcinomas.	Oxygen	0-6	glucose-6-phosphate dehydrogenase	Homo sapiens	86-90
20007731-1	2010	BACKGROUND: Methemoglobin in the blood cannot be detected by conventional pulse oximetry, although it can bias the oximeter"s estimate (Spo2) of the true arterial functional oxygen saturation (Sao2).	Oxygen	174-180	hemoglobin subunit gamma 2	Homo sapiens	12-25
20482313-5	2010	Because oxygen is an important regulator of angiogenesis, we investigated Spry4 expression patterns under hypoxic conditions.	Oxygen	8-14	sprouty RTK signaling antagonist 4	Homo sapiens	74-79
20537895-1	2010	Substituted trityl radicals are important spin probes for functional electron paramagnetic resonance spectroscopy and imaging including oxygen and pH mapping in vivo.	Oxygen	136-142	spindlin 1	Homo sapiens	42-46
20597652-0	2010	Treatment with triamcinolone acetonide prevents decreased retinal levels of decorin in a rat model of oxygen-induced retinopathy.	Oxygen	102-108	decorin	Rattus norvegicus	76-83
20597652-1	2010	PURPOSE: To investigate the effect of triamcinolone acetonide (TA) on retinal expression of decorin in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	118-124	decorin	Rattus norvegicus	92-99
20428526-1	2010	The formation of radicals in the gas phase oxidation of cyclohexane over metal oxides was studied using spin trapping and EPR spectroscopy; the results confirmed that during the catalytic initiation, the oxygen responsible for the radicals formation originates from the lattice of the metal oxide.	Oxygen	204-210	spindlin 1	Homo sapiens	104-108
20398635-5	2010	BDNF (0.5 microg) was injected into the VMH of male Sprague-Dawley rats and oxygen consumption, carbon dioxide production, food intake and SPA were measured for 24h in an indirect calorimeter.	Oxygen	76-82	brain-derived neurotrophic factor	Rattus norvegicus	0-4
20106908-10	2010	Collectively, the novel mt ND6(CR) genotype of the Antarctic radiation represents another major molecular change in Antarctic notothenioid evolution and may reflect an adaptive change conducive to the functioning of the protein (Complex I) machinery of mt respiration in the polar environment, driven by the advent of freezing, oxygen-rich conditions in the Southern Ocean.	Oxygen	328-334	ND6	Salangichthys microdon	27-30
21530505-0	2011	The response of HMGA1 to changes in oxygen availability is evolutionarily conserved.	Oxygen	36-42	high mobility group AT-hook 1a	Danio rerio	16-21
21397736-6	2011	When Sp(O2) was decreased to 85% via manipulation of the FI(O2) (inspired fraction of oxygen) Pa(O2), decreased to 6.1 (5.9-6.2) kPa.	Oxygen	86-92	immunoglobulin kappa variable 1D-39	Homo sapiens	5-10
21397736-6	2011	When Sp(O2) was decreased to 85% via manipulation of the FI(O2) (inspired fraction of oxygen) Pa(O2), decreased to 6.1 (5.9-6.2) kPa.	Oxygen	60-62	immunoglobulin kappa variable 1D-39	Homo sapiens	5-10
21536681-8	2011	Consistent with these findings, hypoxia induced cPLA(2) phosphorylation and activity in VEGF-Src-PLD1-PKCgamma-dependent manner in a mouse model of oxygen-induced retinopathy.	Oxygen	148-154	vascular endothelial growth factor A	Mus musculus	88-92
21568312-1	2011	A single basic residue above the si-face of the flavin ring is the site of oxygen activation in glucose oxidase (GOX) (His516) and monomeric sarcosine oxidase (MSOX) (Lys265).	Oxygen	75-81	hydroxyacid oxidase 1	Homo sapiens	96-111
21568312-1	2011	A single basic residue above the si-face of the flavin ring is the site of oxygen activation in glucose oxidase (GOX) (His516) and monomeric sarcosine oxidase (MSOX) (Lys265).	Oxygen	75-81	hydroxyacid oxidase 1	Homo sapiens	113-116
21568312-5	2011	The protonated form of His516 is required for tight binding of chloride to oxidized GOX and for rapid reaction of reduced GOX with oxygen.	Oxygen	131-137	hydroxyacid oxidase 1	Homo sapiens	84-87
21568312-5	2011	The protonated form of His516 is required for tight binding of chloride to oxidized GOX and for rapid reaction of reduced GOX with oxygen.	Oxygen	131-137	hydroxyacid oxidase 1	Homo sapiens	122-125
21499934-6	2011	Pure oxygen was experimentally shown, for the first time, to affect the human brain activation, at the beginning of early P20 sensory cortical activation and late N100 auditory perception.	Oxygen	5-11	tubulin polymerization promoting protein family member 3	Homo sapiens	122-125
21240521-0	2011	The contrasting effect of estrogen on mRNA expression of VEGF in bovine retinal vascular endothelial cells under different oxygen conditions.	Oxygen	123-129	vascular endothelial growth factor A	Bos taurus	57-61
21314829-8	2011	The oxygen and carbon contents of wire VIM 2 did not exceed their maximum, of 0.070 and 0.050 wt%, according to ASTM standard (ASTM F-2063-00 2001).	Oxygen	4-10	vimentin 2, pseudogene	Homo sapiens	39-44
21382378-4	2011	We show that in cultured embryonic cardiomyocytes hypoxia (1% O(2)) induce time-dependent downregulation of SERCA2a expression.	Oxygen	62-66	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	108-115
21382378-9	2011	This mechanism establishes a link between oxygen supply and calcium activity in embryonic cardiac myocytes that is exploited in cardiac development, and further may offer a possible explanation for the functional depression of SERCA2a seen in ischemic and hypoxic myocardium.	Oxygen	42-48	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	227-234
21491957-6	2011	The rat-worm chimera containing the atypical sGC Gcy-33 H-NOX domain was weakly activated by NO, CO, and O(2), suggesting that atypical guanylate cyclases and NO-sensitive guanylate cyclases have a common molecular mechanism for enzyme activation.	Oxygen	105-109	Guanylate cyclase;Soluble guanylate cyclase gcy-33	Caenorhabditis elegans	49-55
21513309-5	2011	CYP2A6-catalyzed (S)-(-)-nicotine 5"-hydroxylation consists of two reaction steps, that is, the hydrogen transfer from the 5"-position of (S)-(-)-nicotine to the oxygen of Cpd I (the H-transfer step), followed by the recombination of the (S)-(-)-nicotine moiety with the iron-bound hydroxyl group to generate the 5"-hydroxynicotine product (the O-rebound step).	Oxygen	162-168	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
21217781-6	2011	Using a system in which Vhl is acutely disrupted and a combination of ex vivo liver perfusion studies and in vivo oxygen measurements, we demonstrate that Vhl is essential for mitochondrial respiration in vivo.	Oxygen	114-120	von Hippel-Lindau tumor suppressor	Mus musculus	155-158
21174192-4	2011	During LEC separation, in addition to sulfur heterocycles, interesting results were obtained for oxygen-containing compounds.	Oxygen	97-103	C-C motif chemokine ligand 16	Homo sapiens	7-10
20966422-11	2011	Levels of HIF-1alpha were significantly diminished in 5% or 21% oxygen cultures compared with freshly isolated cells.	Oxygen	64-70	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	10-20
20966422-13	2011	High levels of constitutively expressed HIF-1alpha in normoxic Leydig cells suggest potentially unique roles for HIF-1 in Leydig cell responsiveness to oxygen.	Oxygen	152-158	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-50
20357136-4	2010	Overexpression of RAP2.2 resulted in improved plant survival under hypoxia (low-oxygen) stress, whereas lines containing T-DNA knockouts of the gene had poorer survival rates than the wild type.	Oxygen	80-86	related to AP2 2	Arabidopsis thaliana	18-24
20357136-6	2010	Observation of the expression pattern of 32 low-oxygen and ethylene-associated genes showed that RAP2.2 affects only part of the low-oxygen response, particularly the induction of genes encoding sugar metabolism and fermentation pathway enzymes, as well as ethylene biosynthesis genes.	Oxygen	48-54	related to AP2 2	Arabidopsis thaliana	97-103
20357136-6	2010	Observation of the expression pattern of 32 low-oxygen and ethylene-associated genes showed that RAP2.2 affects only part of the low-oxygen response, particularly the induction of genes encoding sugar metabolism and fermentation pathway enzymes, as well as ethylene biosynthesis genes.	Oxygen	133-139	related to AP2 2	Arabidopsis thaliana	97-103
20873618-3	2010	Comparing with the control (21% O2), hypoxia stress reduced the root respiration rate and malate dehydrogenase (MDH) activity significantly, and the impact of 5% O2 stress was more serious than that of 10% O2 stress.	Oxygen	162-164	malate dehydrogenase, mitochondrial	Cucumis melo	90-110
20873618-3	2010	Comparing with the control (21% O2), hypoxia stress reduced the root respiration rate and malate dehydrogenase (MDH) activity significantly, and the impact of 5% O2 stress was more serious than that of 10% O2 stress.	Oxygen	162-164	malate dehydrogenase, mitochondrial	Cucumis melo	90-110
8756971-3	1996	At the Dead Sea, located 402 m below sea level, the barometric pressure reaches 800 mm Hg, thus resulting in high inspired oxygen levels.	Oxygen	123-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	12-15
8756971-3	1996	At the Dead Sea, located 402 m below sea level, the barometric pressure reaches 800 mm Hg, thus resulting in high inspired oxygen levels.	Oxygen	123-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	37-40
20433969-1	2010	This paper describes the fabrication and performance of a range of highly sensitive luminescence-based oxygen sensor films based on the fluorinated sol-gel precursor 3,3,3-trifluoropropyltrimethoxysilane (TFP-TMOS).	Oxygen	103-109	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	205-208
8964413-0	1996	Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells.	Oxygen	66-72	C-C motif chemokine ligand 2	Rattus norvegicus	14-48
20433969-2	2010	The oxygen-sensitive ruthenium complex [Ruthenium(II)-tris(4,7-diphenyl-1,10-phenanthroline)] dichloride, [Ru(dpp)(3)](2+) was entrapped in a wide range of ORMOSILs (organically modified silicates) matrices composed of alkyl and TFP-TMOS sol-gel precursors in different relative ratios.	Oxygen	4-10	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	229-232
20433969-4	2010	The optimum limit of detection was found to be 0.002% of oxygen for the propyltriethoxysilane (PTEOS)/TFP-TMOS-derived film compared to 0.09% for PTEOS-derived films reported previously.	Oxygen	57-63	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	102-105
8666673-7	1996	Purified bone marrow PMNS from wild-type mice released significant amounts of O2- when adherent to fibrinogen-, fibronectin-, or collagen-coated surfaces, in the presence of activating agents such as tumor necrosis factor (TNF) or formyl-methionyl-leucyl-phenylalanine, as described for human PMNs.	Oxygen	78-80	fibronectin 1	Mus musculus	112-123
20689681-10	2010	The phosphate oxygens OP1 or OP2 are used as hydrogen bond acceptors in 12% of all nucleotides, and the ribose ring oxygen O4" and phosphodiester oxygens O3" and O5" are used in 4%, 4%, and 1% of all nucleotides, respectively.	Oxygen	14-21	bone morphogenetic protein 7	Homo sapiens	22-25
20689681-10	2010	The phosphate oxygens OP1 or OP2 are used as hydrogen bond acceptors in 12% of all nucleotides, and the ribose ring oxygen O4" and phosphodiester oxygens O3" and O5" are used in 4%, 4%, and 1% of all nucleotides, respectively.	Oxygen	14-20	bone morphogenetic protein 7	Homo sapiens	22-25
19922526-2	2010	We have recently described an oxygen- and prolyl-4-hydroxylase (PHD)3-dependent stabilization of the activating transcription factor 4 (ATF-4).	Oxygen	30-36	egl-9 family hypoxia inducible factor 3	Homo sapiens	64-69
19922526-2	2010	We have recently described an oxygen- and prolyl-4-hydroxylase (PHD)3-dependent stabilization of the activating transcription factor 4 (ATF-4).	Oxygen	30-36	activating transcription factor 4	Homo sapiens	101-134
19922526-2	2010	We have recently described an oxygen- and prolyl-4-hydroxylase (PHD)3-dependent stabilization of the activating transcription factor 4 (ATF-4).	Oxygen	30-36	activating transcription factor 4	Homo sapiens	136-141
19922526-3	2010	The aim of the present study was to examine if the normoxic destabilization of ATF-4 is regulated by oxygen-dependent proteasomal degradation.	Oxygen	101-107	activating transcription factor 4	Homo sapiens	79-84
19922526-5	2010	Furthermore, we analysed the expression of the ATF-4 target gene GADD153 as a function of oxygen concentration.	Oxygen	90-96	activating transcription factor 4	Homo sapiens	47-52
19922526-7	2010	Normoxic degradation correlated with an oxygen-dependent poly-ubiquitination of ATF-4, which was hindered by hypoxic incubation of the cells.	Oxygen	40-46	activating transcription factor 4	Homo sapiens	80-85
19922526-10	2010	CONCLUSION: Our results demonstrate the involvement of oxygen-dependent proteasomal degradation of ATF-4 in the hypoxia-induced expression of GADD153.	Oxygen	55-61	activating transcription factor 4	Homo sapiens	99-104
8927508-1	1996	There is accumulating evidence from in vitro experiments that the gene expression of the vascular endothelial growth factor (VEGF) is, like that of the erythropoietin (EPO) gene, regulated by the oxygen tension and by divalent cations such as cobalt.	Oxygen	196-202	vascular endothelial growth factor A	Rattus norvegicus	89-123
19922526-11	2010	Taken together, hypoxia/PHD3-regulated stabilization of ATF-4 by hindering oxygen-dependent degradation may play a critical role in linking cell fate decisions to oxygen availability.	Oxygen	75-81	egl-9 family hypoxia inducible factor 3	Homo sapiens	24-28
19922526-11	2010	Taken together, hypoxia/PHD3-regulated stabilization of ATF-4 by hindering oxygen-dependent degradation may play a critical role in linking cell fate decisions to oxygen availability.	Oxygen	75-81	activating transcription factor 4	Homo sapiens	56-61
19922526-11	2010	Taken together, hypoxia/PHD3-regulated stabilization of ATF-4 by hindering oxygen-dependent degradation may play a critical role in linking cell fate decisions to oxygen availability.	Oxygen	163-169	egl-9 family hypoxia inducible factor 3	Homo sapiens	24-28
19922526-11	2010	Taken together, hypoxia/PHD3-regulated stabilization of ATF-4 by hindering oxygen-dependent degradation may play a critical role in linking cell fate decisions to oxygen availability.	Oxygen	163-169	activating transcription factor 4	Homo sapiens	56-61
21387344-0	2011	Spin-driven activation of dioxygen in various metalloenzymes and their inspired models.	Oxygen	26-34	spindlin 1	Homo sapiens	0-4
8927508-1	1996	There is accumulating evidence from in vitro experiments that the gene expression of the vascular endothelial growth factor (VEGF) is, like that of the erythropoietin (EPO) gene, regulated by the oxygen tension and by divalent cations such as cobalt.	Oxygen	196-202	vascular endothelial growth factor A	Rattus norvegicus	125-129
21387344-4	2011	Thanks to its coupling to the constrained DFT methods the ELF analysis reveals the tight connection between the spin state of the adduct and the spatial organization of the oxygen lone pairs.	Oxygen	173-179	spindlin 1	Homo sapiens	112-116
8927508-1	1996	There is accumulating evidence from in vitro experiments that the gene expression of the vascular endothelial growth factor (VEGF) is, like that of the erythropoietin (EPO) gene, regulated by the oxygen tension and by divalent cations such as cobalt.	Oxygen	196-202	erythropoietin	Rattus norvegicus	152-166
20035757-6	2010	Our data show STC 1 for the first time in swine ovary; moreover, we demonstrate STC 1 production by granulosa cells, both in basal condition and in response to oxygen deprivation.	Oxygen	160-166	stanniocalcin 1	Sus scrofa	14-19
8927508-1	1996	There is accumulating evidence from in vitro experiments that the gene expression of the vascular endothelial growth factor (VEGF) is, like that of the erythropoietin (EPO) gene, regulated by the oxygen tension and by divalent cations such as cobalt.	Oxygen	196-202	erythropoietin	Rattus norvegicus	168-171
20035757-6	2010	Our data show STC 1 for the first time in swine ovary; moreover, we demonstrate STC 1 production by granulosa cells, both in basal condition and in response to oxygen deprivation.	Oxygen	160-166	stanniocalcin 1	Sus scrofa	80-85
8721582-7	1996	The authors hypothesize, that Fc gamma receptor specific autoantibodies may play a role in the pathology of autoimmune diseases by stimulating Fc gamma-receptor-bearing cells to release oxygen intermediates, different lysosomal hydrolases and cytokines or by blocking the phagocytosis of immune complexes.	Oxygen	186-192	Fc gamma receptor Ia	Homo sapiens	30-47
20165787-1	2010	UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.	Oxygen	112-118	translocator protein	Homo sapiens	242-245
21338581-5	2011	It was found that neuronal damage induced by oxygen-glucose deprivation was accompanied by a significant decrease in both HIF-1alpha and HIF-3alpha mRNA levels in CA1 but not CA3 neurons.	Oxygen	45-51	carbonic anhydrase 1	Homo sapiens	163-166
21481773-2	2011	Nro1 regulates the stability of the N-terminal transcription factor domain of Sre1 (Sre1N) by inhibiting the action of the prolyl 4-hydroxylase-like Ofd1 in an oxygen-dependent manner.	Oxygen	160-166	OFD1 centriole and centriolar satellite protein	Homo sapiens	149-153
21481773-4	2011	Follow-up studies showed that Nro1 defines a new class of nuclear import adaptor that functions both in Ofd1 nuclear localization and in the oxygen-dependent inhibition of Ofd1 to control the hypoxic response.	Oxygen	141-147	OFD1 centriole and centriolar satellite protein	Homo sapiens	172-176
8721582-7	1996	The authors hypothesize, that Fc gamma receptor specific autoantibodies may play a role in the pathology of autoimmune diseases by stimulating Fc gamma-receptor-bearing cells to release oxygen intermediates, different lysosomal hydrolases and cytokines or by blocking the phagocytosis of immune complexes.	Oxygen	186-192	Fc gamma receptor Ia	Homo sapiens	143-160
8634451-1	1996	The phagocyte cytochrome b558, a heterodimer comprised of gp91phox and p22phox, is a flavocytochrome that mediates the transfer of electrons from NADPH to molecular oxygen in the respiratory burst oxidase.	Oxygen	165-171	cytochrome b-245 alpha chain	Homo sapiens	71-78
21277814-9	2011	The contribution of dissolved molecular oxygen to the relaxation rate was found to be independent of microwave frequency up to 94 GHz for lipid-type spin-labels in membranes.	Oxygen	40-46	spindlin 1	Homo sapiens	149-153
21277814-10	2011	This contribution is expressed in terms of the oxygen transport parameter W=T1-1(Air)-T1-1(N2), which is a function of both concentration and translational diffusion of oxygen in the local environment of a spin-label.	Oxygen	47-53	spindlin 1	Homo sapiens	206-210
21277814-10	2011	This contribution is expressed in terms of the oxygen transport parameter W=T1-1(Air)-T1-1(N2), which is a function of both concentration and translational diffusion of oxygen in the local environment of a spin-label.	Oxygen	169-175	spindlin 1	Homo sapiens	206-210
21277814-11	2011	The new capabilities in measurement of the oxygen transport parameter using saturation-recovery (SR) EPR at Q- and W-band have been demonstrated in saturated (DMPC) and unsaturated (POPC) lipid bilayer membranes with the use of stearic acid (n-SASL) and phosphatidylcholine (n-PC) spin-labels, and compared with results obtained earlier at X-band.	Oxygen	43-49	spindlin 1	Homo sapiens	281-285
21467578-4	2011	GUN4 was also proposed to attenuate the production of reactive oxygen species (ROS) by binding and shielding light-exposed porphyrins from collisions with O2.	Oxygen	155-157	protein GENOMES UNCOUPLED 4	Arabidopsis thaliana	0-4
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	Oxygen	194-198	immunoglobulin kappa variable 1D-39	Homo sapiens	105-109
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	Oxygen	194-198	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	Oxygen	194-198	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
19861159-4	2010	By hydroxylating HIF-1alpha in an oxygen-dependent manner PHDs and FIH-1 function as oxygen-sensing enzymes of HIF signalling.	Oxygen	34-40	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	67-72
19861159-4	2010	By hydroxylating HIF-1alpha in an oxygen-dependent manner PHDs and FIH-1 function as oxygen-sensing enzymes of HIF signalling.	Oxygen	85-91	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	67-72
19861159-9	2010	More recent studies support the view that NO regulates HIF-1 by modulating the activity of the oxygen-sensor enzymes PHDs and FIH-1.	Oxygen	95-101	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	126-131
19823932-2	2010	However, when slices were transferred to a medium containing oxygen and glucose (reoxygenation conditions, or REO), S100B release reached 500% of its control value.	Oxygen	61-67	S100 calcium binding protein B	Rattus norvegicus	116-121
20093090-6	2010	GAPDH, IGFR2, CCNB1, and GREM1 were up-regulated in the oocytes matured in low oxygen, whereas GLUT1, GAPDH, LDHA and GREM1 were up-regulated and PTGS2 down-regulated in the cumulus cells from the M5 group (P &lt; or = 0.05).	Oxygen	79-85	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	0-5
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	Oxygen	194-198	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
8720667-1	1996	The inhibitive effects of anti-CD11a/CD18 (LFA-1) and anti-CD54 (ICAM-1) antibodies on the generation of superoxide anion (O2-) by polymorphonuclear leukocytes (PMNs) was elucidated in rats induced with experimental acute pancreatitis.	Oxygen	123-125	integrin subunit alpha L	Rattus norvegicus	43-48
20977891-7	2011	Taken together our results show that the Cdk5/p35 complex may significantly contribute to modulation of Hif-1alpha stabilisation and impact neuronal survival during oxygen deprivation.	Oxygen	165-171	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	46-49
19843542-8	2010	The dependence of PHF8 activity on oxygen availability is interesting because the occurrence of fetal cleft lip has been demonstrated to increase with maternal hypoxia in mouse studies.	Oxygen	35-41	PHD finger protein 8	Mus musculus	18-22
8603833-9	1996	Supplemental oxygen therapy reduced or eliminated the overexpression of VEGF expression, astrocyte degeneration, and formation of preretinal vessels.	Oxygen	13-19	vascular endothelial growth factor A	Felis catus	72-76
20448301-5	2010	The XPS results showed that the N2 and O2 plasma pre-treatment produced nitride and oxide on the substrate surfaces, such as TiO2, TiO, Fe2O3, CrN and TiNO.	Oxygen	39-41	mex-3 RNA binding family member D	Homo sapiens	151-155
8609249-20	1996	The data also show that cellular factors in addition to ceruloplasmin, possibly active oxygen species and/or lipoxygenases, are essential and act synergistically with ceruloplasmin to oxidize LDL.	Oxygen	87-93	ceruloplasmin	Homo sapiens	56-69
19646539-1	2010	We used event-related functional magnetic resonance imaging (fMRI) to determine blood oxygen-level-dependent (BOLD) signal changes following microsaccades, visually-guided saccades, and eyeblinks in retinotopically mapped visual cortical areas V1-V3 and hMT+.	Oxygen	86-92	histamine N-methyltransferase	Homo sapiens	254-257
21429222-6	2011	RESULTS: At baseline, higher plasma MMP-9 levels were cross-sectionally associated with lower FEV1 (p=0.03), FVC (p&lt;0.001), carbon monoxide transfer factor (p=0.03), resting oxygen saturation (p=0.02), and ISWT distance walked (p=0.02) but were not associated with radiographic lung density or total lung capacity (TLC).	Oxygen	177-183	matrix metallopeptidase 9	Homo sapiens	36-41
21429222-7	2011	In longitudinal analyses, MMP-9 predicted a further decline in transfer factor (p=0.04) and oxygen saturation (p&lt;0.001).	Oxygen	92-98	matrix metallopeptidase 9	Homo sapiens	26-31
21193583-2	2011	We have previously obtained evidence of the involvement of cytochrome P-450, possibly of the 3A subfamily (CYP3A), in oxygen sensing and have also identified endothelin (ET)-1 as the attendant effector for the contraction.	Oxygen	118-124	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	107-112
8609249-20	1996	The data also show that cellular factors in addition to ceruloplasmin, possibly active oxygen species and/or lipoxygenases, are essential and act synergistically with ceruloplasmin to oxidize LDL.	Oxygen	87-93	ceruloplasmin	Homo sapiens	167-180
21193583-10	2011	RA also promoted an oxygen contraction in the Cyp3a(-/-) DA.	Oxygen	20-26	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	46-51
20035564-0	2010	Multiple-turnover isotopic labeling of Fmoc- and Boc-protected amino acids with oxygen isotopes.	Oxygen	80-86	BOC cell adhesion associated, oncogene regulated	Homo sapiens	49-52
8559166-6	1996	Thus, Mb synthesis in nonatrophic RRF may increase to compensate for mitochondrial dysfunction and to supply sufficient oxygen to mitochondria, but this compensatory function may be impaired in atrophic RRF.	Oxygen	120-126	myoglobin	Homo sapiens	6-8
20062524-3	2010	We also show that the phagocytosis of yeast and the release of reactive oxygen intermediates in response to Candida albicans challenge are impaired in macrophages from Dectin-1 deficient mice treated with PPARgamma ligands or IL-13.	Oxygen	72-78	C-type lectin domain family 7, member a	Mus musculus	168-176
21073657-6	2011	Lowering of oxygen from 21% to 2.5% led to increased [Ca(2+) ](i) and CaSR expression.	Oxygen	12-18	calcium-sensing receptor	Rattus norvegicus	70-74
21278085-7	2011	In astrocytic cultures, oxygen and glucose deprivation induced sigma-1 receptor expression and actin dependent membrane raft formation, the latter blocked by sigma-1 receptor small interfering RNA silencing and pharmacological inhibition.	Oxygen	24-30	sigma non-opioid intracellular receptor 1	Rattus norvegicus	63-79
21278085-7	2011	In astrocytic cultures, oxygen and glucose deprivation induced sigma-1 receptor expression and actin dependent membrane raft formation, the latter blocked by sigma-1 receptor small interfering RNA silencing and pharmacological inhibition.	Oxygen	24-30	sigma non-opioid intracellular receptor 1	Rattus norvegicus	158-174
19588900-0	2009	Spin-polarized density functional theory study of reactivity of diatomic molecule on bimetallic system: the case of O2 dissociative adsorption on Pt monolayer on Fe(001).	Oxygen	116-118	spindlin 1	Homo sapiens	0-4
19954242-2	2009	Among them, the nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana deserves particular attention, as it combines an extremely high oxygen affinity with an internal hexacoordination of the distal histidine HisE7 to the heme iron in the absence of exogenous ligands.	Oxygen	135-141	hemoglobin 1	Arabidopsis thaliana	40-44
22532771-5	2011	Low levels of serum sRAGE would allow unopposed serum AGE availability for binding with RAGE, resulting in the generation of oxygen radicals and proinflammatory molecules that have deleterious consequences and promote myocardial damage.	Oxygen	125-131	advanced glycosylation end-product specific receptor	Homo sapiens	21-25
8542580-2	1996	Because the microfilament network is one of the earliest targets of oxidative stress and because phosphorylation of HSP27 is strongly induced by reactive oxygen metabolites, we have investigated the role of HSP27 phosphorylation in regulating actin dynamics in response to oxidative stress.	Oxygen	154-160	heat shock protein family B (small) member 1	Homo sapiens	116-121
21225074-1	2011	The oxygen exchange at SnO(2) surfaces strongly depends on surface termination, which is affected by the oxygen chemical potential.	Oxygen	4-10	strawberry notch homolog 2	Homo sapiens	23-26
21225074-1	2011	The oxygen exchange at SnO(2) surfaces strongly depends on surface termination, which is affected by the oxygen chemical potential.	Oxygen	105-111	strawberry notch homolog 2	Homo sapiens	23-26
19893042-3	2009	TRAIL and its receptor, DR5, were expressed in wild-type retinas at all time points evaluated (postnatal days 12, 17, 21, 24) during oxygen-induced retinopathy and in age-matched room air control animals.	Oxygen	133-139	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	0-5
8772534-1	1996	By participating in glutathione (GSH) synthesis, gamma-glutamyl transpeptidase (GGT) influences the GSH redox cycle, which is a major contributor in protecting against reactive oxygen metabolites.	Oxygen	177-183	gamma-glutamyltransferase 1	Rattus norvegicus	49-78
19549065-9	2009	This hypothesis may provide explanation for some of the disparate results seen in reverse genetic experiments regarding the impact of AOX on the reactive oxygen network and oxidative damage.	Oxygen	154-160	acyl-CoA oxidase 1	Homo sapiens	134-137
19549068-7	2009	Apart from changes in glycolytic flux, the role of both the cytochrome-c oxidase (COX) and the alternative oxidase (AOX) in the adaptive response of respiration to changes in the oxygen availability are discussed.	Oxygen	179-185	acyl-CoA oxidase 1	Homo sapiens	95-114
19549068-7	2009	Apart from changes in glycolytic flux, the role of both the cytochrome-c oxidase (COX) and the alternative oxidase (AOX) in the adaptive response of respiration to changes in the oxygen availability are discussed.	Oxygen	179-185	acyl-CoA oxidase 1	Homo sapiens	116-119
19549068-9	2009	It is suggested that AOX could play a role in maintaining oxygen homeostasis within the mitochondrion.	Oxygen	58-64	acyl-CoA oxidase 1	Homo sapiens	21-24
19549068-10	2009	Because of the relative low affinity for oxygen of AOX as compared to COX, the alternative oxidase will not interfere with COX activity, but AOX activity will reduce the free oxygen concentration, thereby decreasing the production of reactive oxygen species (ROS) inside the mitochondrion.	Oxygen	41-47	acyl-CoA oxidase 1	Homo sapiens	51-54
19549068-10	2009	Because of the relative low affinity for oxygen of AOX as compared to COX, the alternative oxidase will not interfere with COX activity, but AOX activity will reduce the free oxygen concentration, thereby decreasing the production of reactive oxygen species (ROS) inside the mitochondrion.	Oxygen	41-47	acyl-CoA oxidase 1	Homo sapiens	79-98
19549068-10	2009	Because of the relative low affinity for oxygen of AOX as compared to COX, the alternative oxidase will not interfere with COX activity, but AOX activity will reduce the free oxygen concentration, thereby decreasing the production of reactive oxygen species (ROS) inside the mitochondrion.	Oxygen	175-181	acyl-CoA oxidase 1	Homo sapiens	51-54
19549068-10	2009	Because of the relative low affinity for oxygen of AOX as compared to COX, the alternative oxidase will not interfere with COX activity, but AOX activity will reduce the free oxygen concentration, thereby decreasing the production of reactive oxygen species (ROS) inside the mitochondrion.	Oxygen	175-181	acyl-CoA oxidase 1	Homo sapiens	141-144
21222437-2	2011	Phototropin is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) that absorb blue light and a serine/theroine kinase domain responsible for light-dependent autophosphorylation leading to cellular signaling cascades.	Oxygen	37-43	NAC domain containing protein 35	Arabidopsis thaliana	69-73
8772534-1	1996	By participating in glutathione (GSH) synthesis, gamma-glutamyl transpeptidase (GGT) influences the GSH redox cycle, which is a major contributor in protecting against reactive oxygen metabolites.	Oxygen	177-183	gamma-glutamyltransferase 1	Rattus norvegicus	80-83
21300290-3	2011	Oxygen can reach the catalytic center independently from the presence of a bound histone peptide, implying that LSD1 can complete subsequent demethylation cycles without detaching from the nucleosomal particle.	Oxygen	0-6	lysine demethylase 1A	Homo sapiens	112-116
8772534-2	1996	This study determined the effect of prolonged exposure of neonatal rats to &gt; 98% oxygen on expression of GGT and on GSH metabolism.	Oxygen	84-90	gamma-glutamyltransferase 1	Rattus norvegicus	108-111
8924597-6	1996	The rate constant for the inactivation of HPPD by 1 was (1.5 +/- 0.2) x 10(-5) s-1 nM-1 as determined by progress curve data of oxygen consumed by HPPD with time.	Oxygen	128-134	4-hydroxyphenylpyruvate dioxygenase	Rattus norvegicus	42-46
21304818-1	2011	Neuroglobin (Ngb) is a recently discovered vertebrate globin that is expressed in the brain and can reversibly bind oxygen.	Oxygen	116-122	hemoglobin alpha embryonic-3	Danio rerio	5-11
19244202-5	2009	Newborn mice exposed to 85% O2 had no developmental decrease in Txnip protein levels and a delayed increase in VEGF protein levels.	Oxygen	28-30	vascular endothelial growth factor A	Mus musculus	111-115
19244202-8	2009	In conclusion, oxidation of Trx1 and sustained Txnip expression in the lungs of newborn mice exposed to 85% oxygen is likely to severely attenuate normal Trx1 function.	Oxygen	108-114	thioredoxin 1	Mus musculus	28-32
19244202-8	2009	In conclusion, oxidation of Trx1 and sustained Txnip expression in the lungs of newborn mice exposed to 85% oxygen is likely to severely attenuate normal Trx1 function.	Oxygen	108-114	thioredoxin 1	Mus musculus	154-158
8924597-6	1996	The rate constant for the inactivation of HPPD by 1 was (1.5 +/- 0.2) x 10(-5) s-1 nM-1 as determined by progress curve data of oxygen consumed by HPPD with time.	Oxygen	128-134	4-hydroxyphenylpyruvate dioxygenase	Rattus norvegicus	147-151
19679655-8	2009	To understand the functional role of each disulfide, small molecules and the physiological substrate protein Mia40 were used as electron donors in oxygen consumption assays.	Oxygen	147-153	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	109-114
21143139-7	2011	A second example can be found in the chloride intracellular channel 1 (CLIC1), whose expression is related to macrophage activation, undergoes translocation from the cytosol to the plasma membrane (activation) of microglia exposed to amyloid beta-peptide, and participates in amyloid beta-peptide-induced neurotoxicity through the generation of reactive oxygen species.	Oxygen	354-360	chloride intracellular channel 1	Rattus norvegicus	37-69
21143139-7	2011	A second example can be found in the chloride intracellular channel 1 (CLIC1), whose expression is related to macrophage activation, undergoes translocation from the cytosol to the plasma membrane (activation) of microglia exposed to amyloid beta-peptide, and participates in amyloid beta-peptide-induced neurotoxicity through the generation of reactive oxygen species.	Oxygen	354-360	chloride intracellular channel 1	Rattus norvegicus	71-76
21257819-2	2011	Although low oxygen induces Snail transcription, thereby stimulating EMT, a direct role of hypoxia-inducible factor (HIF) in this process remains to be demonstrated.	Oxygen	13-19	snail family zinc finger 1	Mus musculus	28-33
19738058-0	2009	c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.	Oxygen	72-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
21257819-8	2011	HIF knockdown with siRNA at 2% oxygen and overexpression of an oxygen-insensitive HIF (HIF-DeltaODD) mutant at 21% oxygen showed that HIF regulates Snail activation and subsequent cell migration.	Oxygen	31-37	snail family zinc finger 1	Mus musculus	148-153
12226176-6	1996	Light, which causes the accumulation of active forms of oxygen in photosynthetic organelles, also stimulated catalase and ascorbate peroxidase activities in dividing protoplasts.	Oxygen	56-62	catalase isozyme 1	Nicotiana tabacum	109-117
21257819-8	2011	HIF knockdown with siRNA at 2% oxygen and overexpression of an oxygen-insensitive HIF (HIF-DeltaODD) mutant at 21% oxygen showed that HIF regulates Snail activation and subsequent cell migration.	Oxygen	63-69	snail family zinc finger 1	Mus musculus	148-153
21257819-8	2011	HIF knockdown with siRNA at 2% oxygen and overexpression of an oxygen-insensitive HIF (HIF-DeltaODD) mutant at 21% oxygen showed that HIF regulates Snail activation and subsequent cell migration.	Oxygen	63-69	snail family zinc finger 1	Mus musculus	148-153
21266088-7	2011	RESULTS: A structure-function analysis allowed to discover that the boron-oxygen core present in 2-APB and in the borinate ester analogues is absolutely required for the dual effects on SOCE.	Oxygen	74-80	arginyl aminopeptidase	Homo sapiens	99-102
19738058-2	2009	We report here that c-Jun associates with HIF-1alpha via its oxygen-dependent degradation domain, masks the sites for ubiquitination, and thus protects HIF-1alpha from proteasome-executing degradation.	Oxygen	61-67	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
19661455-5	2009	Consequently, the oxygen buffering capacity, calculated from myoglobin concentration/SDH activity was increased in CHF: type I fibers 11.4 +/- 2.1 s, type II fibers 13.6 +/- 3.9 s in CHF vs. type I fibers 7.8 +/- 0.9 s, type II fibers 7.5 +/- 1.0 s in control, all P &lt; 0.01).	Oxygen	18-24	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	85-88
21266088-8	2011	Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function.	Oxygen	41-47	arginyl aminopeptidase	Homo sapiens	12-15
12226176-6	1996	Light, which causes the accumulation of active forms of oxygen in photosynthetic organelles, also stimulated catalase and ascorbate peroxidase activities in dividing protoplasts.	Oxygen	56-62	peroxidase N1	Nicotiana tabacum	132-142
19817002-4	2009	The logistic model was chosen to evaluate the effect of PrA on S. cerevisiae cell growth, and PrA was found to promote cell growth against insufficient oxygen condition in steady state cultivation, but had no effect in shaking cultivation.	Oxygen	152-158	proteinase A	Saccharomyces cerevisiae S288C	94-97
8530499-2	1995	This binding of C1q to neutrophils triggers the generation of toxic oxygen species.	Oxygen	68-74	complement C1q A chain	Homo sapiens	16-19
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase	Homo sapiens	25-28
19724858-6	2009	However, upregulation of LOX, LOXL2 and LOXL4 was significantly correlated with absence of lymphovascular invasion (P=0.012, 0.014 and 0.005, respectively), suggesting that the oxygen tension in or around the tumors may be an important regulator for the differential expression of LOX, LOXL2 and LOXL4 in colorectal cancer.	Oxygen	177-183	lysyl oxidase	Homo sapiens	30-33
22046328-6	2011	Synaptotagmin-7 KO mice had lower body weight and body fat content, and exhibited higher oxygen consumption and basal metabolic rate.	Oxygen	89-95	synaptotagmin VII	Mus musculus	0-15
21799876-5	2011	Recent evidence shows that SCF triggers accumulation of the inducible alpha subunit of hypoxia-inducible factor 1 (HIF-1) in hematopoietic cells--a transcription complex that plays a pivotal role in cellular adaptation to low oxygen availability.	Oxygen	226-232	KIT ligand	Homo sapiens	27-30
8530401-5	1995	The distinct roles of SOD1 in copper and oxygen radical homeostasis could also be separated genetically: the pmr1, bsd2, and ATX1 genes that suppress oxygen toxicity in sod1 mutants failed to suppress the copper sensitivity of these cells.	Oxygen	150-156	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	125-129
19733906-8	2009	These data suggest that placental expression of BPGM can influence maternal BPG concentrations and supports a hypothesis under which BPG synthesized in the placenta may act on maternal haemoglobin to enhance delivery of oxygen to the developing fetus.	Oxygen	220-226	2,3-bisphosphoglycerate mutase	Mus musculus	48-52
20938977-9	2011	These data provide key information for the origin of the neuroprotective and physiological role of Ngb and will promote the treatment of reactive oxygen species (ROS)-related diseases using this novel oxygen-binding globin.	Oxygen	146-152	neuroglobin	Homo sapiens	99-102
7488164-6	1995	The COX6 upstream activation region, UAS6, contains both glucose and heme responsive regions, and COX6 oxygen regulation was transduced through UAS6 by heme, as has been described for other oxygen regulated genes in yeast.	Oxygen	190-196	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	4-8
19751675-2	2009	Ferrous Ngb binds dioxygen with high affinity and the O(2) adduct is able to scavenge NO.	Oxygen	18-26	neuroglobin	Homo sapiens	8-11
7488164-6	1995	The COX6 upstream activation region, UAS6, contains both glucose and heme responsive regions, and COX6 oxygen regulation was transduced through UAS6 by heme, as has been described for other oxygen regulated genes in yeast.	Oxygen	190-196	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	98-102
20889973-7	2010	atmin(Delta/Delta) mouse embryonic fibroblasts accumulated DNA damage and prematurely entered senescence when cultured at atmospheric oxygen levels (20%), but this defect was rescued by addition of an antioxidant and also by culturing cells at physiological oxygen levels (3%).	Oxygen	134-140	ATM interactor	Mus musculus	0-5
20889973-7	2010	atmin(Delta/Delta) mouse embryonic fibroblasts accumulated DNA damage and prematurely entered senescence when cultured at atmospheric oxygen levels (20%), but this defect was rescued by addition of an antioxidant and also by culturing cells at physiological oxygen levels (3%).	Oxygen	258-264	ATM interactor	Mus musculus	0-5
21546993-4	2010	The RDS can be used to measure oxygen uptake in microliter-scale volumes with a reversibly sealed sample chamber, which contains a porphyrin-based oxygen sensor.	Oxygen	31-37	peripherin 2	Homo sapiens	4-7
21546993-4	2010	The RDS can be used to measure oxygen uptake in microliter-scale volumes with a reversibly sealed sample chamber, which contains a porphyrin-based oxygen sensor.	Oxygen	147-153	peripherin 2	Homo sapiens	4-7
19753310-3	2009	The effect of transient hypoxia treatment (1% oxygen, 4 h/day) on TGFbeta1 (5 ng/ml)-induced alpha-smooth muscle actin (alpha-SM actin) expression was examined by immunofluorescence, flow cytometry, and immunocytochemistry 72 h after treatment.	Oxygen	46-52	actin, aortic smooth muscle	Oryctolagus cuniculus	93-118
19672489-1	2009	This paper shows for the first time that the spectral features of the ternary complex of tyrosinase/O2/phenol, trapped at low temperature using the very slow substrate 3,5-difluorophenol, are those of a mu-eta2:eta2-peroxidodicopper(II) species, and that this remains the only enzyme species under turnover and substrate saturation conditions.	Oxygen	100-102	tyrosinase	Homo sapiens	89-99
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Oxygen	206-212	complement C3	Homo sapiens	178-181
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Oxygen	206-212	complement C3	Homo sapiens	311-314
7491924-3	1995	EGF-stimulated proliferation of RPTC was preceded by a rapid (within 4 h) induction of glycolysis and a decrease in basal and ouabain-sensitive oxygen consumption (20 and 30%, respectively).	Oxygen	144-150	epidermal growth factor	Homo sapiens	0-3
19500668-4	2009	The enzyme activity toward single oxygen-induced DNA damage and mRNA expression levels of Ercc1, Neil1, and Ogg1 remained unaltered with age.	Oxygen	34-40	8-oxoguanine DNA-glycosylase 1	Mus musculus	108-112
20817051-10	2010	These data demonstrate that AnxA2 expression in osteoblasts is under the control of VEGF, which may have implications for both angiogenesis and bone mineralization under low oxygen conditions.	Oxygen	174-180	vascular endothelial growth factor A	Mus musculus	84-88
7491924-6	1995	These results show that EGF rapidly stimulates the pentose cycle, shifts glucose metabolism from gluconeogenesis to glycolysis, and decreases oxygen consumption before any increase in proliferation.	Oxygen	142-148	epidermal growth factor	Homo sapiens	24-27
20723561-5	2010	Results show that antioxidant enzymes helped minimize methemoglobin (non-carrier of oxygen) formation during the conjugation process and also during storage at 4 C over a period of 1 month.	Oxygen	84-90	hemoglobin subunit gamma 2	Homo sapiens	54-67
8541016-3	1995	We have observed the induction of a specific cytochrome P-450 monooxygenase, P-450IA1 (CYP1A1), to be a sensitive method for assessing the response of microcarrier-attached Hep G2 cells to stress resulting from hydrodynamic shear and oxygen deprivation.	Oxygen	66-72	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
20824409-0	2010	Hyperbaric oxygen effect on MMP-9 after a vascular insult.	Oxygen	11-17	matrix metallopeptidase 9	Homo sapiens	28-33
19630374-3	2009	The resulting alkenylrhodium(I) intermediate undergoes beta-oxygen elimination to open the oxirane ring in a syn-selective fashion.	Oxygen	60-66	synemin	Homo sapiens	109-112
19520738-3	2009	CD39 activity may be modulated by vascular injury, inflammation, and altered oxygen tension.	Oxygen	77-83	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	0-4
20824409-4	2010	Several studies have examined the effect of hyperbaric oxygen (HBO) on MMP-9 expression.	Oxygen	55-61	matrix metallopeptidase 9	Homo sapiens	71-76
8606853-15	1995	In addition, 2.7 kb RAR alpha mRNA was decreased with the combination of DEX and oxygen exposure (0.63 +/- 0.06).	Oxygen	81-87	retinoic acid receptor, alpha	Rattus norvegicus	20-29
20977250-2	2010	Here, with scanning transmission electron microscopy, electron energy-loss spectroscopy, and first-principles calculations, both the Ce and oxygen sublattices of a (210)Sigma5 CeO(2) grain boundary were determined.	Oxygen	140-146	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	169-175
19302442-6	2009	RESULTS: Exposure of primary mouse hepatocytes to 1% oxygen stimulated nuclear accumulation of HIF-1alpha and upregulated PAI-1, vascular endothelial cell growth factor and the vasoactive peptides adrenomedullin-1 (ADM-1) and ADM-2.	Oxygen	53-59	adrenomedullin 2	Mus musculus	226-231
7575509-5	1995	In yeast, COX6 transcription is regulated by several factors thought to mediate respiratory adaptation including growth phase induction, oxygen dependence, and glucose repression.	Oxygen	137-143	cytochrome c oxidase subunit VI	Saccharomyces cerevisiae S288C	10-14
19544448-4	2009	Culture in low (4%) oxygen promoted survival of pNSCs by inhibiting apoptosis-inducing factor (AIF)-dependent cell death, although pNSCs undergo both AIF- and caspase-mediated cell death in 20% oxygen.	Oxygen	20-26	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	68-93
19544448-4	2009	Culture in low (4%) oxygen promoted survival of pNSCs by inhibiting apoptosis-inducing factor (AIF)-dependent cell death, although pNSCs undergo both AIF- and caspase-mediated cell death in 20% oxygen.	Oxygen	20-26	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	95-98
20136511-6	2010	After disulfide transfer from Tim40/Mia40 to substrate proteins, Tim40/Mia40 is reoxidized again by Erv1, which is then oxidized by electron transfer to either cytochrome c or molecular oxygen.	Oxygen	186-192	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	36-41
20136511-6	2010	After disulfide transfer from Tim40/Mia40 to substrate proteins, Tim40/Mia40 is reoxidized again by Erv1, which is then oxidized by electron transfer to either cytochrome c or molecular oxygen.	Oxygen	186-192	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	71-76
8537230-11	1995	Interleukin-3 also increased gamma-globin synthesis in low oxygen in normal but not sickle cultures.	Oxygen	59-65	interleukin 3	Homo sapiens	0-13
20833648-5	2010	Sca-1(+) cells with mito-Cx-43 reduced cytosolic accumulation of cytochrome c, lowered caspase-3 activity, and improved survival during index oxygen-glucose deprivation as determined by terminal deoxynucleotidyl transferase dUTP nick-end labelling and lactate dehydrogenase assays.	Oxygen	142-148	lymphocyte antigen 6 complex, locus A	Mus musculus	0-5
20095328-6	2009	The S3 [(0.046 +/- 0.005) nano atoms oxygen x mg(-1) x min(-1)] and RCR of NAC-protected group were significantly higher than group B (P&lt;0.01), S4 [(0.011 +/- 0.001) nano atoms oxygen x mg(-1) x min(-1)] of NAC-protected group was significantly lower than bromoxynil-poisoned group (P&lt; 0.01).	Oxygen	180-186	NLR family, pyrin domain containing 1A	Mus musculus	75-78
19586058-5	2009	Surface oxygen promotes the destruction of CH(2)O through the formation of CH(2)O(2), which readily decomposes to CHO(2) and then in turn to CO(2) and adsorbed hydrogen.	Oxygen	8-14	EBP cholestenol delta-isomerase	Homo sapiens	114-119
19401150-1	2009	FIH-1, factor inhibiting hypoxia-inducible factor-1 (HIF-1), regulates oxygen sensing by hydroxylating an asparagine within HIF-alpha.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	0-51
19401150-4	2009	We determined the contributions of substrate sequence composition and length and of oxygen concentration to the FIH-1-binding and/or hydroxylation of Notch1-4 and compared them with those for HIF-1alpha.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	112-117
19401150-10	2009	Importantly, we demonstrate that the K(m) of FIH-1 for oxygen at the preferred Site 1 of Notch1-3, 10-19 microM, is an order of magnitude lower than that for Site 2 or HIF-1alpha.	Oxygen	55-61	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	45-50
20847132-8	2010	At 2% O(2), LH2 and LOX gene expression levels were higher than control cultures (340 +- 53 and 136 +- 29%, respectively), and these levels increased even further with decreasing oxygen concentrations (611 +- 176 and 228 +- 45%, respectively, at 0.5% O(2)).	Oxygen	6-10	lysyl oxidase	Homo sapiens	20-23
20847132-8	2010	At 2% O(2), LH2 and LOX gene expression levels were higher than control cultures (340 +- 53 and 136 +- 29%, respectively), and these levels increased even further with decreasing oxygen concentrations (611 +- 176 and 228 +- 45%, respectively, at 0.5% O(2)).	Oxygen	179-185	lysyl oxidase	Homo sapiens	20-23
20948541-0	2010	FIH1 (factor inhibiting HIF-1) in the kidney: more than an oxygen sensor?	Oxygen	59-65	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	0-4
8567462-7	1995	In contrast, hindlimb lactate uptake (P &lt; .02) and the ratio of glucose to oxygen uptake (P &lt; .08) were reduced by somatotropin.	Oxygen	78-84	somatotropin	Bos taurus	121-133
20869949-2	2010	In this study, we demonstrated that HP (3% oxygen) induced the high expression of both chemokine stromal-derived factor-1 (SDF-1) receptors, CXCR4 and CXCR7, in MSCs.	Oxygen	43-49	C-X-C motif chemokine receptor 4	Homo sapiens	141-146
20869949-2	2010	In this study, we demonstrated that HP (3% oxygen) induced the high expression of both chemokine stromal-derived factor-1 (SDF-1) receptors, CXCR4 and CXCR7, in MSCs.	Oxygen	43-49	atypical chemokine receptor 3	Homo sapiens	151-156
19731830-8	2009	The selected model could be successfully calibrated for the model parameters by means of substantially higher oxygen half saturation constants for heterotrophs (K(OH)) and autotrophs (K(OA)) determined as 2.0 mg O2/L and 2.25 mg O2/L, respectively.	Oxygen	110-116	immunoglobulin kappa variable 1D-39	Homo sapiens	212-222
19614926-7	2009	In contrast, P-cadherin and the desmosomal proteins desmoplakin and desmoglein-1 were refractory to oxygen deprivation.	Oxygen	100-106	desmoglein 1	Homo sapiens	68-80
7603981-5	1995	When stressed by exposure to &gt; 99% oxygen, the EC-SOD null mutant mice display a considerable reduction in survival time compared to wild-type mice and an earlier onset of severe lung edema.	Oxygen	38-44	superoxide dismutase 3, extracellular	Mus musculus	50-56
19406746-6	2009	We subsequently discovered that SMG-1 kinase activity was activated by hypoxia, and depletion of SMG-1 up-regulated MAPK activity under low oxygen.	Oxygen	140-146	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	97-102
20730184-4	2010	The SAR covers 1,4-through 1,8-H-migration, as well as oxo- and hydroxy substitution in various positions relative to the radical oxygen and the migrating H.	Oxygen	130-136	sarcosine dehydrogenase	Homo sapiens	4-7
7623107-11	1995	Hypoxic regulation of VEGF expression in the intact developing retina was demonstrated by showing that oxygen-enriched atmospheres that inhibit vessel formation also suppress endogenous VEGF production.	Oxygen	103-109	vascular endothelial growth factor A	Rattus norvegicus	22-26
20833055-2	2010	Incorporation of a diphenylurea moiety at the C4-position of the pyrrolo[3,2-d]pyrimidine core via an oxygen linker resulted in compounds that were potent inhibitors of VEGFR2 kinase.	Oxygen	102-108	kinase insert domain receptor	Homo sapiens	169-175
19055876-8	2009	RESULTS: Exposure of PC12 cells to 1% oxygen for 6 hours decreased IL-7 mRNA by 77% using RT-PCR (p&lt;0.01).	Oxygen	38-44	interleukin 7	Rattus norvegicus	67-71
19055876-9	2009	Exposure to 1% oxygen for 24 hours decreased IL-7 protein in the medium by 21% (p&lt;0.05).	Oxygen	15-21	interleukin 7	Rattus norvegicus	45-49
20429727-6	2010	From here it was possible to identify a fraction of probesets induced at low oxygen independent of pH in these two cell lines, this fraction included HIG2, NDRG1, PAI1 and RORA.	Oxygen	77-83	N-myc downstream regulated 1	Homo sapiens	156-161
7623107-11	1995	Hypoxic regulation of VEGF expression in the intact developing retina was demonstrated by showing that oxygen-enriched atmospheres that inhibit vessel formation also suppress endogenous VEGF production.	Oxygen	103-109	vascular endothelial growth factor A	Rattus norvegicus	186-190
20429727-6	2010	From here it was possible to identify a fraction of probesets induced at low oxygen independent of pH in these two cell lines, this fraction included HIG2, NDRG1, PAI1 and RORA.	Oxygen	77-83	RAR related orphan receptor A	Homo sapiens	172-176
19172312-4	2009	As such, in the gas phase, the relative reactivity exhibits the trend isomer B &gt; isomer A, while at the highest level, B2//B1 with zero point energy and solvation corrections, the relative reactivity follows the order isomer B &gt; isomer A &gt; isomer C. Thus, the calculated reaction pathway shows that pyridine rings perpendicular to the Fe-O axis result in more reactive species, and a pyridine ring coordinated trans to the oxygen atom leads to the least reactive isomer.	Oxygen	432-438	immunoglobulin kappa variable 5-2	Homo sapiens	122-128
7585153-4	1995	We now show that as a consequence of glycation, PHF-tau from AD and AGE-tau generate oxygen free radicals, thereby activating transcription via nuclear factor-kappa B, increasing amyloid beta-protein precursor and release of approximately 4 kD amyloid beta-peptides.	Oxygen	85-91	microtubule associated protein tau	Homo sapiens	48-55
19411534-7	2009	In vitro studies and cell culture experiments imply that neuroglobin may detoxify reactive oxygen or nitric oxide.	Oxygen	91-97	neuroglobin	Homo sapiens	57-68
20309720-8	2010	Real-time reverse transcriptase-polymerase chain reaction analysis (RT-PCR) showed that CXCR4 mRNA expression in GH3 cells was increased by hypoxia (1% oxygen), and a cDNA microarray analysis revealed that inhibin beta-C expression was diminished.	Oxygen	152-158	C-X-C motif chemokine receptor 4	Rattus norvegicus	88-93
7585153-4	1995	We now show that as a consequence of glycation, PHF-tau from AD and AGE-tau generate oxygen free radicals, thereby activating transcription via nuclear factor-kappa B, increasing amyloid beta-protein precursor and release of approximately 4 kD amyloid beta-peptides.	Oxygen	85-91	microtubule associated protein tau	Homo sapiens	52-55
7768907-5	1995	The oxygen affinity of reduced azaheme myoglobin, 0.010 mm Hg, is 50 times larger than that of the native myoglobin.	Oxygen	4-10	myoglobin	Homo sapiens	39-48
20473556-5	2010	Hypoxic rats supplemented with glucose alone and with oxygen showed a reversal of the receptor alterations and changes in GAD and HIF-1A to near control.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	130-136
20709391-0	2010	The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia?	Oxygen	76-82	ATP binding cassette subfamily A member 1	Homo sapiens	47-52
20709391-9	2010	Culture of JAr trophoblast cells and human first trimester placental explants under low oxygen lead to increased expression of LXRA and ABCA1 which was further enhanced by the LXR agonist T0901317.	Oxygen	88-94	ATP binding cassette subfamily A member 1	Homo sapiens	136-141
20633670-14	2010	IL-1 significantly reduced pS6 at all oxygen tensions.	Oxygen	38-44	taste 2 receptor member 63 pseudogene	Homo sapiens	27-30
19637563-9	2009	PST1305 gene might participate in biological nitrogen fixation by involving in the electron transport or the oxygen protection mechanism of nitrogenase.	Oxygen	109-115	PST_RS06645	Pseudomonas stutzeri A1501	0-7
19251694-11	2009	SEPT9_v1 also protected HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation.	Oxygen	167-173	receptor for activated C kinase 1	Homo sapiens	133-138
19251694-12	2009	In conclusion, a new mechanism of oxygen-independent activation of HIF-1 has been identified that is mediated by SEPT9_v1 blockade of RACK1 activity on HIF-1alpha degradation.	Oxygen	34-40	receptor for activated C kinase 1	Homo sapiens	134-139
19331391-3	2009	Increasing size of the substituents at C-1 and C-5 of the diene favors kinetic products arising from oxygen addition at the nonconjugated position, C-3, of the pentadienyl radical intermediate.	Oxygen	101-107	complement C3	Homo sapiens	148-151
19331391-6	2009	Groups at C-1 and C-5 of the diene can influence product distribution based upon (a) steric demand in the oxygen-radical reaction and (b) the influence of substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products.	Oxygen	106-112	complement C3	Homo sapiens	196-199
19852088-7	2009	AlkB uses a non-heme mononuclear iron(II) and the cofactors 2-ketoglutarate (2KG) and dioxygen to effect oxidative demethylation of the DNA base lesions 1-methyladenine (1-meA), 3-methylcytosine (3-meC), 1-methylguanine (1-meG), and 3-methylthymine (3-meT).	Oxygen	86-94	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
7768907-5	1995	The oxygen affinity of reduced azaheme myoglobin, 0.010 mm Hg, is 50 times larger than that of the native myoglobin.	Oxygen	4-10	myoglobin	Homo sapiens	106-115
20865124-4	2010	First, EGL-9 is the enzyme that targets HIF-1 for oxygen-dependent degradation via the VHL-1 E3 ligase.	Oxygen	50-56	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	7-12
7763260-7	1995	Oxygen consumption was significantly decreased in all clones carrying the 11778/ND4 primary mutation demonstrating its pathogenic role in impairing cell respiration.	Oxygen	0-6	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	80-83
20669954-7	2010	Comparison of the predicted and experimental values leads to the conclusion that the radical is cationic H(4)B(*+), suggesting that NOS stabilizes this protonated form to utilize the cofactor in a unique dual one-electron redox role, where it can deliver an electron to the active site for reductive oxygen activation and also remove an electron from the active site to generate NO and not NO(-).	Oxygen	300-306	H4 clustered histone 4	Homo sapiens	105-110
19299799-7	2009	For H-I more than 2-3 h, ECA was significantly decreased and Sc(O2) was significantly increased during reperfusion, suggesting continued depression of tissue O(2) metabolism.	Oxygen	158-162	immunoglobulin kappa variable 1D-39	Homo sapiens	61-66
19162213-6	2009	The number of GLUT2 mRNA copies was significantly increased in response to both acute (1.9 mg/L, dissolved oxygen for 4 h) and chronic (4.3 mg/L, DO for 15 days) hypoxia conditions.	Oxygen	107-113	solute carrier family 2 member 2	Homo sapiens	14-19
20555027-6	2010	Oxygen consumption was significantly increased in CNP-Tg/Nppc(-/-) mice compared with that in CNP-Tg/Nppc(+/+) mice.	Oxygen	0-6	natriuretic peptide type C	Mus musculus	50-53
11607539-6	1995	This protein is a catalase, and binding of SA and its biologically active analogues inhibited catalase"s ability to convert H2O2 to O2 and H2O.	Oxygen	126-128	catalase isozyme 1	Nicotiana tabacum	18-26
20555027-6	2010	Oxygen consumption was significantly increased in CNP-Tg/Nppc(-/-) mice compared with that in CNP-Tg/Nppc(+/+) mice.	Oxygen	0-6	natriuretic peptide type C	Mus musculus	57-61
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	Oxygen	54-62	tryptophan 2,3-dioxygenase	Homo sapiens	203-206
20361220-9	2010	The results reveal the subtle differences between the TDO and IDO reactions and highlight the importance of protein matrix in modulating stereoelectronic factors for oxygen activation and the stabilization of both transition and intermediate states.	Oxygen	166-172	tryptophan 2,3-dioxygenase	Homo sapiens	54-57
19295603-3	2009	Here we introduce this method with the design of an oxygen transport protein, akin to human neuroglobin.	Oxygen	52-58	neuroglobin	Homo sapiens	92-103
11607539-6	1995	This protein is a catalase, and binding of SA and its biologically active analogues inhibited catalase"s ability to convert H2O2 to O2 and H2O.	Oxygen	126-128	catalase isozyme 1	Nicotiana tabacum	94-102
7636807-9	1995	The oxygen electrode and spectrophotometer data indicate that there is a superoxide-generating NAD(P)H oxidase on the blastocyst surface.	Oxygen	4-10	NADPH oxidase 1	Oryctolagus cuniculus	95-110
18684560-7	2009	The potential for oxygen evolution at the Ti/SnO(2)+Sb(2)O(3)/PbO(2) anode is highest, then Ti/SnO(2)+Sb(2)O(3)/MnO(x), following Ti/SnO(2)+Sb(2)O(3)/RuO(2)+PbO(2).	Oxygen	18-24	strawberry notch homolog 2	Homo sapiens	45-48
18684560-7	2009	The potential for oxygen evolution at the Ti/SnO(2)+Sb(2)O(3)/PbO(2) anode is highest, then Ti/SnO(2)+Sb(2)O(3)/MnO(x), following Ti/SnO(2)+Sb(2)O(3)/RuO(2)+PbO(2).	Oxygen	18-24	strawberry notch homolog 2	Homo sapiens	95-98
18684560-7	2009	The potential for oxygen evolution at the Ti/SnO(2)+Sb(2)O(3)/PbO(2) anode is highest, then Ti/SnO(2)+Sb(2)O(3)/MnO(x), following Ti/SnO(2)+Sb(2)O(3)/RuO(2)+PbO(2).	Oxygen	18-24	strawberry notch homolog 2	Homo sapiens	95-98
20079867-5	2010	In addition to the capacity of these proteins to promote fusion, mitofusin 2 or OPA1 regulate mitochondrial metabolism and loss-of-function reduces oxygen consumption and the capacity to oxidize substrates.	Oxygen	148-154	mitofusin 2	Homo sapiens	65-76
12228480-4	1995	Catalase and other scavenging mechanisms also affect the overall level of active oxygen.	Oxygen	81-87	catalase isozyme 1	Nicotiana tabacum	0-8
18776134-8	2009	In addition, IL-6 Tg(+) mice exposed to 100% oxygen exhibited reduced ASK-1 levels and enhanced SOCS-1 expression compared with wild-type mice.	Oxygen	45-51	suppressor of cytokine signaling 1	Mus musculus	96-102
19005161-1	2009	Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-twitch skeletal muscles that have a high oxygen demand.	Oxygen	16-22	myoglobin	Mus musculus	0-9
19005161-1	2009	Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-twitch skeletal muscles that have a high oxygen demand.	Oxygen	131-137	myoglobin	Mus musculus	0-9
19005161-4	2009	In the present study, adult mice exposed to 10% oxygen for periods up to 3 wk exhibited increased myoglobin expression only in the working heart, whereas myoglobin was either diminished or unchanged in skeletal muscle groups.	Oxygen	48-54	myoglobin	Mus musculus	98-107
18978343-0	2009	The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration.	Oxygen	57-63	lysophosphatidic acid receptor 1	Rattus norvegicus	44-48
20418384-9	2010	Similarly, exposure of mouse pulmonary endothelial cells (MLEC) to hyperoxia (95% oxygen; 72 h) resulted in activation of caspase-3 and -7 and significantly decreased the content of CL molecular species containing C(18:2) and C(20:4) as well as PS molecular species containing C(22:5) and C(22:6).	Oxygen	82-88	caspase 3	Mus musculus	122-138
20522651-2	2010	A component of the E3 ubiquitin ligase complex, von Hippel-Lindau (VHL) facilitates oxygen-dependent polyubiquitination and proteasomal degradation of HIFalpha subunits.	Oxygen	84-90	von Hippel-Lindau tumor suppressor	Mus musculus	48-65
20583310-0	2010	The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney.	Oxygen	79-85	nitric oxide synthase 1	Rattus norvegicus	31-35
18818904-3	2009	OBJECTIVES: We intend to see which brain circuits are activated when nicotine is given in animals naive for nicotine and whether the beta2*nAChRs are needed for its activation of the blood oxygen level dependent (BOLD) signal in all brain areas.	Oxygen	189-195	hemoglobin, beta adult minor chain	Mus musculus	133-138
7614005-2	1995	Mice of the HBO-sensitive strain (CD1) were exposed to 600 kPa O2 for 24 min versus 90 min for mice of the normal C57 strain, so that 50% of the mice in both strains developed a generalized convulsion.	Oxygen	63-65	CD1 antigen complex	Mus musculus	34-37
19267995-4	2009	Cytochrome c was found to enhance the catalytic rate of Drosophila melanogaster PPO under reduced oxygen conditions, and cytochrome c became reduced during PPO catalysis.	Oxygen	98-104	Cytochrome c proximal	Drosophila melanogaster	0-12
20583310-2	2010	We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption in streptozotocin-diabetic rats.	Oxygen	157-163	nitric oxide synthase 1	Rattus norvegicus	101-131
20583310-2	2010	We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption in streptozotocin-diabetic rats.	Oxygen	157-163	nitric oxide synthase 1	Rattus norvegicus	133-137
20583310-9	2010	The increased oxygen consumption by diabetic proximal tubular cells correlated with increased protein expressions of p47(phox) and nNOS and the treatments prevented these increases.	Oxygen	14-20	nitric oxide synthase 1	Rattus norvegicus	131-135
20583310-11	2010	Inhibition of either NADPH-oxidase or nNOS prevented the increased oxygen consumption.	Oxygen	67-73	nitric oxide synthase 1	Rattus norvegicus	38-42
7616763-8	1995	It is possible that the age-related decrease in CPT-I activity may result from an in vivo accumulation of oxygen-derived radical damage.	Oxygen	106-112	carnitine palmitoyltransferase 1b, muscle	Mus musculus	48-53
20421134-2	2010	FTIR results suggested that in R(2)Sn(IV)NAC (R = Me, Bu, Ph) complexes NAC(2-) behaves as dianionic tridentate ligand coordinating the tin(IV) atom, through ester-type carboxylate, acetate carbonyl oxygen atom and the deprotonated thiolate group.	Oxygen	199-205	X-linked Kx blood group	Homo sapiens	72-75
19047680-3	2009	We therefore sought to characterize the regulation of GDF15 by iron and oxygen and to define the involvement or otherwise of HIF and IRP pathways.	Oxygen	72-78	growth differentiation factor 15	Homo sapiens	54-59
7713921-5	1995	Using O2- production to measure cell signaling, we found that binding by high affinity IgGs of various species, as well as by murine hybrid IgGs containing only one high affinity heavy chain, resulted in a marked increase in Fc gamma RI-mediated signaling.	Oxygen	6-8	Fc gamma receptor Ia	Homo sapiens	225-236
19154150-0	2009	Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.	Oxygen	37-43	KRAS proto-oncogene, GTPase	Homo sapiens	104-107
20528036-1	2010	Spin-polarized density functional theory with the inclusion of on-site Coulomb correction (DFT+U) calculation is carried out to study the oxygen vacancy and migration of Ce(1-x)Zr(x)O(2) in a series of Ce/Zr ratios.	Oxygen	138-144	spindlin 1	Homo sapiens	0-4
20446668-2	2010	If oxygen is carefully excluded from the reaction, the key NaOH-catalyzed aldol dimerization of the alpha-ketoamide proceeded efficiently to give Boc-protected eusynstyelamide A.	Oxygen	3-9	BOC cell adhesion associated, oncogene regulated	Homo sapiens	146-149
19079320-6	2009	Particularly enhanced spheroidal expression of SDF-1alpha and its receptor CXCR4, the major chemokine system in embryonic vasculogenesis, in a low-oxygen environment was detected.	Oxygen	147-153	C-X-C motif chemokine receptor 4	Homo sapiens	75-80
7733370-0	1995	Critical intracellular O2 in myocardium as determined by 1H nuclear magnetic resonance signal of myoglobin.	Oxygen	23-25	myoglobin	Homo sapiens	97-106
19840905-4	2010	In the construction of the biosensor tyrosinase enzyme was immobilized on a Clark-type dissolved oxygen probe which was covered with a oxygen sensitive teflon membrane, by using a chemical covalent immobilization method based on gelatine and bifunctional reagent, glutaraldehyde.	Oxygen	97-103	tyrosinase	Homo sapiens	37-47
19840905-4	2010	In the construction of the biosensor tyrosinase enzyme was immobilized on a Clark-type dissolved oxygen probe which was covered with a oxygen sensitive teflon membrane, by using a chemical covalent immobilization method based on gelatine and bifunctional reagent, glutaraldehyde.	Oxygen	135-141	tyrosinase	Homo sapiens	37-47
7733370-1	1995	The 1H nuclear magnetic resonance (NMR) signal of tissue myoglobin has provided an opportunity to determine the critical O2 level in saline-perfused myocardium at room temperature.	Oxygen	121-123	myoglobin	Homo sapiens	57-66
19840905-5	2010	The principle of the measurement was based on the determination of the differentiation of dissolved oxygen level in the enzymatic reaction catalyzed by tyrosinase in the absence and the presence of copper ions.	Oxygen	100-106	tyrosinase	Homo sapiens	152-162
19197346-11	2009	This conclusion is supported by our demonstration of decreased oxygen consumption in sod-2 mutant worms.	Oxygen	63-69	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	85-90
7599929-14	1995	administration of CAS 1609 (0.3-3.0 mg kg-1) decreased, in a dose-related fashion, preload and afterload of the heart, cardiac output, left ventricular work and myocardial oxygen consumption.	Oxygen	172-178	BCAR1 scaffold protein, Cas family member	Homo sapiens	18-21
19323289-6	2009	Also, dissolved oxygen greatly increased the rate of phenol degradation and reduced the formation of AOX.	Oxygen	16-22	acyl-CoA oxidase 1	Homo sapiens	101-104
20345238-11	2010	Represented within this haplotype block of NGB is the region that codes for the oxygen-binding portion of NGB.	Oxygen	80-86	neuroglobin	Homo sapiens	43-46
20345238-11	2010	Represented within this haplotype block of NGB is the region that codes for the oxygen-binding portion of NGB.	Oxygen	80-86	neuroglobin	Homo sapiens	106-109
7842760-7	1995	Group 1 received exposure to 15.1% oxygen at sea level, the HIT.	Oxygen	35-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	45-48
20306188-1	2010	Pyrroquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) of acetic acid bacteria is a membrane-bound enzyme involved in the acetic acid fermentation by oxidizing ethanol to acetaldehyde coupling with reduction of membranous ubiquinone (Q), which is, in turn, re-oxidized by ubiquinol oxidase, reducing oxygen to water.	Oxygen	310-316	aldo-keto reductase family 1 member A1	Homo sapiens	33-54
20345897-0	2010	Ixr1p regulates oxygen-dependent HEM13 transcription.	Oxygen	16-22	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	33-38
19001419-4	2009	Oxygen consumption assays with purified recombinant Ero1-Lalpha revealed that it utilizes oxygen as a terminal electron acceptor producing one disulfide bond and one molecule of hydrogen peroxide per dioxygen molecule consumed.	Oxygen	0-6	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	52-63
19001419-4	2009	Oxygen consumption assays with purified recombinant Ero1-Lalpha revealed that it utilizes oxygen as a terminal electron acceptor producing one disulfide bond and one molecule of hydrogen peroxide per dioxygen molecule consumed.	Oxygen	90-96	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	52-63
19001419-4	2009	Oxygen consumption assays with purified recombinant Ero1-Lalpha revealed that it utilizes oxygen as a terminal electron acceptor producing one disulfide bond and one molecule of hydrogen peroxide per dioxygen molecule consumed.	Oxygen	200-208	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	52-63
19590187-8	2009	The rate of oxygen consumption was decreased in association with increased levels of hypoxia inducible factor 1alpha, lipid peroxidation (P&lt;0.01, n=3) and superoxide dismutase activity (P&lt;0.01, n=3) in dexamethasone treated rat heart.	Oxygen	12-18	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	85-116
19671042-3	2009	Mutations in pVHL can be found in familial and sporadic hemangioblastomas, clear cell carcinomas of the kidney, pheochromocytomas and inherited forms of erythrocytosis, illustrating the importance of disrupted molecular oxygen sensing in the pathogenesis of these diseases.	Oxygen	220-226	von Hippel-Lindau tumor suppressor	Mus musculus	13-17
20167673-2	2010	Hence, a reduction in SERCA2 abundance is expected to reduce work performance and maximal oxygen uptake (VO2max) and to limit the response to exercise training.	Oxygen	90-96	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	22-28
7842760-9	1995	MEASUREMENTS AND MAIN RESULTS: For all three groups combined, the arterial oxygen tension at sea level (PaO2SL) explained significant variability in PaO2 during hypoxic exposure according to the following formula: PaO2 during exposure = 0.417 (PaO2SL)] + 17.802 (n = 42; r = 0.756; p &lt; 0.001).	Oxygen	75-81	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	93-96
7753500-4	1995	Furthermore, NSE showed neuroprotective action on cultured neocortical neurons in a low-oxygen atmosphere.	Oxygen	88-94	enolase 2	Rattus norvegicus	13-16
20140661-1	2010	Chuvash polycythemia, the first hereditary disease associated with dysregulated oxygen-sensing to be recognized, is characterized by a homozygous germ-line loss-of-function mutation of the VHL gene (VHL(R200W)) resulting in elevated hypoxia inducible factor (HIF)-1alpha and HIF-2alpha levels, increased red cell mass and propensity to thrombosis.	Oxygen	80-86	von Hippel-Lindau tumor suppressor	Mus musculus	189-192
20140661-1	2010	Chuvash polycythemia, the first hereditary disease associated with dysregulated oxygen-sensing to be recognized, is characterized by a homozygous germ-line loss-of-function mutation of the VHL gene (VHL(R200W)) resulting in elevated hypoxia inducible factor (HIF)-1alpha and HIF-2alpha levels, increased red cell mass and propensity to thrombosis.	Oxygen	80-86	von Hippel-Lindau tumor suppressor	Mus musculus	199-202
20046639-0	2009	Endothelial nitric oxide synthase expression is progressively increased in primary cerebral microvascular endothelial cells during hyperbaric oxygen exposure.	Oxygen	142-148	nitric oxide synthase 3	Rattus norvegicus	0-33
19263596-0	2009	Retraction notice to: "Long-term oxygen administration reduces  plasma adrenomedullin levels in patients with obstructive sleep  apnea syndrome" [Sleep Medicine 2007;9:80-7].	Oxygen	33-39	adrenomedullin	Homo sapiens	71-85
7999755-1	1994	Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., &amp; Shoenborn, B. P. (1991) J. Mol.	Oxygen	70-76	myoglobin	Homo sapiens	157-166
18974212-4	2009	Vascular endothelial growth factor (VEGF) secretion by ASCs increased as an inverse function of oxygen tension, with progressively higher VEGF expression at 21%, 5%, and 1% oxygen, respectively.	Oxygen	96-102	vascular endothelial growth factor A	Mus musculus	0-34
18974212-4	2009	Vascular endothelial growth factor (VEGF) secretion by ASCs increased as an inverse function of oxygen tension, with progressively higher VEGF expression at 21%, 5%, and 1% oxygen, respectively.	Oxygen	96-102	vascular endothelial growth factor A	Mus musculus	36-40
18974212-4	2009	Vascular endothelial growth factor (VEGF) secretion by ASCs increased as an inverse function of oxygen tension, with progressively higher VEGF expression at 21%, 5%, and 1% oxygen, respectively.	Oxygen	173-179	vascular endothelial growth factor A	Mus musculus	0-34
18974212-4	2009	Vascular endothelial growth factor (VEGF) secretion by ASCs increased as an inverse function of oxygen tension, with progressively higher VEGF expression at 21%, 5%, and 1% oxygen, respectively.	Oxygen	173-179	vascular endothelial growth factor A	Mus musculus	36-40
20158611-7	2010	RESULTS: Exposure of hepatocytes to 1% oxygen increased expression of alpha-smooth muscle actin, vimentin, Snail and fibroblast-specific protein-1 (FSP-1).	Oxygen	39-45	vimentin	Mus musculus	97-105
20158611-7	2010	RESULTS: Exposure of hepatocytes to 1% oxygen increased expression of alpha-smooth muscle actin, vimentin, Snail and fibroblast-specific protein-1 (FSP-1).	Oxygen	39-45	snail family zinc finger 1	Mus musculus	107-112
19900484-3	2010	HIFs are transcription factors involved in the cellular response to low oxygen, including upregulation of transcripts like vascular endothelial growth factor (VEGF) and EPO.	Oxygen	72-78	vascular endothelial growth factor A	Mus musculus	123-157
19900484-3	2010	HIFs are transcription factors involved in the cellular response to low oxygen, including upregulation of transcripts like vascular endothelial growth factor (VEGF) and EPO.	Oxygen	72-78	vascular endothelial growth factor A	Mus musculus	159-163
7810720-9	1994	It is concluded that one of the potential mechanisms of expression of HSP 70 by I/R may be oxygen radicals.	Oxygen	91-97	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	70-76
20170204-6	2010	The KrF(2) ligands are coordinated trans to the fluorine atoms of BrOF(2)(+) with the AsF(6)(-) anion coordinated trans to oxygen.	Oxygen	123-129	arylsulfatase F	Homo sapiens	86-89
7977826-5	1994	These results suggest that induction of VEGF mRNA is upregulated by oxygen deprivation in the heart and that not only infarction but also chronic ischemia in the clinical setting could induce VEGF as a potent angiogenesis factor to stimulate coronary collateral formation.	Oxygen	68-74	vascular endothelial growth factor A	Rattus norvegicus	40-44
20300197-3	2010	Here we show that oxygen regulates the expression of the muscle glycogen synthase (GYS1).	Oxygen	18-24	glycogen synthase 1	Homo sapiens	83-87
7524599-4	1994	Granulocyte colony-stimulating factor, by augmenting white cell production, pulmonary sequestration and margination and production of toxic oxygen species, may exacerbate underlying subclinical bleomycin pulmonary toxicity.	Oxygen	140-146	colony stimulating factor 3	Homo sapiens	0-37
20148560-2	2010	LSD1 belongs to the amine oxidase enzyme superfamily which utilize molecular oxygen to transform amines to imines that are hydrolytically cleaved to formaldehyde.	Oxygen	77-83	lysine demethylase 1A	Homo sapiens	0-4
7935419-1	1994	Oxygen toxicity in Saccharomyces cerevisiae strains lacking superoxide dismutase can be suppressed through mutations in either the BSD1 or BSD2 gene.	Oxygen	0-6	Bsd2p	Saccharomyces cerevisiae S288C	139-143
20048154-6	2010	In addition, Zn(2+)-mediated neuronal injury under oxygen-glucose deprivation conditions was also diminished by silencing TRPM7.	Oxygen	51-57	transient receptor potential cation channel subfamily M member 7	Homo sapiens	122-127
20023176-5	2010	We found that chronic oxygen-induced lung injury decreased pulmonary sGCalpha(1) and PKGI immunoreactivity in mouse pups and that exposure to a TGF-beta-neutralizing antibody prevented this reduction of sGC and PKGI protein expression.	Oxygen	22-28	guanylate cyclase 1, soluble, alpha 1	Mus musculus	69-80
20107925-5	2010	We confirmed neurite extension was mediated through oxygen-responsive mechanisms using small molecules that promote or inhibit HIF-1alpha stabilization.	Oxygen	52-58	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	127-137
20010313-6	2010	This study shows that IUV without oxygen can reduce alveolarization, whereas ventilation with oxygen (6 h), even at levels found in air (21%), increases distal lung tissue volumes, elastin deposition, myofibroblast differentiation, and apoptosis.	Oxygen	94-100	elastin	Homo sapiens	181-188
7945375-7	1994	This interaction of Adriamycin with myoglobin may impose significant restrictions on oxygen storage and delivery in vivo.	Oxygen	85-91	myoglobin	Homo sapiens	36-45
19923416-0	2010	Nitric oxide originating from NOS1 controls oxygen utilization and electrolyte transport efficiency in the diabetic kidney.	Oxygen	44-50	nitric oxide synthase 1	Rattus norvegicus	30-34
8089148-3	1994	We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity.	Oxygen	204-206	phosphoglycerate kinase 1	Homo sapiens	75-100
20075204-3	2010	Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix.	Oxygen	36-42	catechol-O-methyltransferase	Mus musculus	151-179
20075204-3	2010	Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix.	Oxygen	36-42	catechol-O-methyltransferase	Mus musculus	181-185
20075204-3	2010	Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix.	Oxygen	60-66	catechol-O-methyltransferase	Mus musculus	151-179
20075204-3	2010	Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix.	Oxygen	60-66	catechol-O-methyltransferase	Mus musculus	181-185
8089148-3	1994	We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity.	Oxygen	204-206	phosphoglycerate kinase 1	Homo sapiens	102-106
7825058-3	1994	P19O2R exhibited reduced oxygen-mediated micronucleation and a 10- to 20-fold reduction of the forward mutation rate at the HPRT locus in 20% O2.	Oxygen	3-5	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	124-128
19914870-3	2010	OBJECTIVE: The aim of this study was to see if cTnI was associated with the alveolar-arterial oxygen gradient (DeltaA-a), a marker of severity in CAP.	Oxygen	94-100	troponin I3, cardiac type	Homo sapiens	47-51
7847182-4	1994	We found that the rank order of potency for producing plasma extravasation in the rat trachea was NK-1 receptor agonist ([Sar9, Met(O2)11] SP) &gt; substance P &gt; neurokinin A &gt; neurokinin B.	Oxygen	132-134	tachykinin receptor 1	Rattus norvegicus	98-111
19578226-10	2010	Rates of mortality and duration of oxygen requirement was significantly higher in babies who failed CPAP.	Oxygen	35-41	centromere protein J	Homo sapiens	100-104
8020609-3	1994	Low oxygen tension decreased the number of binding sites of both EGF (mean = 44%) and TGF-beta (mean = 33%).	Oxygen	4-10	epidermal growth factor	Homo sapiens	65-68
20010896-8	2010	Specific disruption of PHD1 induces hypoxic tolerance, without angiogenesis and erythrocytosis, through the reprogramming of basal oxygen metabolism and decreased generation of oxidative stress in hypoxic mitochondria.	Oxygen	131-137	egl-9 family hypoxia-inducible factor 2	Mus musculus	23-27
20010896-9	2010	A specific PHD1 inhibitor might, therefore, offer a novel therapy for abnormal oxygen metabolism not only in the diabetic kidney, but also in other diseases for which hypoxia is a final, common pathway.	Oxygen	79-85	egl-9 family hypoxia-inducible factor 2	Mus musculus	11-15
8020609-6	1994	We conclude that low oxygen tension decreases EGF and TGF-beta receptor binding and synthesis.	Oxygen	21-27	epidermal growth factor	Homo sapiens	46-49
7939599-4	1994	We hypothesized that cobalt interacts with an oxygen sensitive mechanism in the carotid chemoreception and in erythropoietin producing cells.	Oxygen	46-52	erythropoietin	Rattus norvegicus	110-124
20000378-1	2010	The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the observed oxygen-oxygen distance of 2.45 A.	Oxygen	307-313	carbonic anhydrase 2	Homo sapiens	31-52
20000378-1	2010	The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the observed oxygen-oxygen distance of 2.45 A.	Oxygen	314-320	carbonic anhydrase 2	Homo sapiens	31-52
8209387-9	1994	The combination of both high oxygen concentration and the presence of either pyruvate or alpha-ketoglutarate was necessary to effectively protect COx against cyanide poisoning.	Oxygen	29-35	coproporphyrinogen oxidase	Rattus norvegicus	146-149
20006097-4	2010	The calibration function is linear up to 19mgL(-1) dissolved oxygen and an injection frequency of 17 per hour is achieved.	Oxygen	61-67	LLGL scribble cell polarity complex component 1	Homo sapiens	43-49
8195121-11	1994	There are five extended regions of &gt; or = 50% identity to CYP1A1 as follows: (a) 51-118; (b) 199-222; (c) 326-343 (I-helix, O2-binding threonine); (d) 357-430; and (e) 460-487 (heme-binding cysteine).	Oxygen	127-129	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	61-67
19960064-5	2010	Emphasis is given to parallels with the permeation profiles of oxygen and nitric oxide that are determined from spin-label relaxation enhancements by using nonlinear continuous-wave EPR and saturation recovery EPR, and with permeation profiles of D(2)O that are determined by using (2)H electron spin echo envelope modulation spectroscopy.	Oxygen	63-69	spindlin 1	Homo sapiens	112-116
19923925-5	2010	First, mitochondrial respiration, as measured by mitochondrial oxygen consumption, was suppressed in NIH-3T3 cells transformed with H-Ras(Q61L).	Oxygen	63-69	Harvey rat sarcoma virus oncogene	Mus musculus	132-137
19755933-2	2010	We hypothesized that O2 exposure immediately after birth is associated with altered blood spot MMP 9 and beta chemokine concentrations.	Oxygen	21-23	matrix metallopeptidase 9	Homo sapiens	95-100
19755933-5	2010	On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure.	Oxygen	77-79	C-C motif chemokine ligand 5	Homo sapiens	29-35
20306428-1	2010	Methemoglobinemia; an increased concentration of methemoglobin in the blood, is an altered state of hemoglobin whereby the ferrous form of iron is oxidized to the ferric state, rendering the heme moiety incapable of carrying oxygen.	Oxygen	225-231	hemoglobin subunit gamma 2	Homo sapiens	49-62
7514201-4	1994	GM-CSF (10 ng/ml) increased the rate of O2- production by 79%, caused a fivefold increase in fMLP-induced myeloperoxidase (MPO) secretion, and strongly enhanced CD11b expression.	Oxygen	40-42	colony stimulating factor 2	Homo sapiens	0-6
21113404-4	2010	Following eight days in culture at 1% oxygen, C(2)C(12) muscle myoblasts displayed a reduction of PGC-1alpha, PPAR-alpha, and RXR-alpha mRNA, as well as CPT-1b and UCP-2 mRNA.	Oxygen	38-44	retinoid X receptor alpha	Homo sapiens	126-135
19755485-4	2010	We report that culture at 20% oxygen decreased hES cell proliferation and resulted in a significantly reduced expression of SOX2, NANOG and POU5F1 (OCT4) mRNA as well as POU5F1 protein compared with hypoxic conditions.	Oxygen	30-36	SRY-box transcription factor 2	Homo sapiens	124-128
19755485-4	2010	We report that culture at 20% oxygen decreased hES cell proliferation and resulted in a significantly reduced expression of SOX2, NANOG and POU5F1 (OCT4) mRNA as well as POU5F1 protein compared with hypoxic conditions.	Oxygen	30-36	Nanog homeobox	Homo sapiens	130-135
7514201-5	1994	In contrast, G-CSF (50 ng/ml) only slightly increased O2- production (by 15%), and MPO secretion and CD11b expression remained unchanged.	Oxygen	54-56	colony stimulating factor 3	Homo sapiens	13-18
19968319-9	2009	Friction for the oxygen-containing MoS(2) sheets was influenced by not only the Coulomb repulsive interaction but also the atomic-scale roughness of the MoS(2)/MoS(2) sliding interface.	Oxygen	17-23	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	35-38
7908225-1	1994	D-Amino acid oxidase catalyzes the oxidation of D-amino acids to imino acids with subsequent transfer of the electrons to molecular oxygen.	Oxygen	132-138	D-amino acid oxidase	Homo sapiens	0-20
19968319-9	2009	Friction for the oxygen-containing MoS(2) sheets was influenced by not only the Coulomb repulsive interaction but also the atomic-scale roughness of the MoS(2)/MoS(2) sliding interface.	Oxygen	17-23	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	153-156
19968319-9	2009	Friction for the oxygen-containing MoS(2) sheets was influenced by not only the Coulomb repulsive interaction but also the atomic-scale roughness of the MoS(2)/MoS(2) sliding interface.	Oxygen	17-23	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	153-156
19843527-4	2009	Comparative analysis of the published CARM1 crystal structures reveals that the hydroxyl group of Ser(217) forms a strong hydrogen bond with the carbonyl oxygen atom of Tyr(154) to lock the cofactor S-adenosylmethionine inside the binding cavity.	Oxygen	154-160	coactivator associated arginine methyltransferase 1	Homo sapiens	38-43
8169607-2	1994	The X-band EPR spectra and the absorption spectra in the Soret region of the nitrosylated derivative of ferrous native and carboxymethylated cytochrome c display the same basic characteristics reported for the beef heart cytochrome a3 in cytochrome c oxidase, and horseradish and baker"s yeast cytochrome c peroxidase, as well as the high affinity form of oxygen carrying proteins.	Oxygen	356-362	cytochrome c, somatic	Equus caballus	141-153
19797161-7	2009	MEASUREMENTS AND MAIN RESULTS: mRNA and protein levels and activity of lysyl oxidases (Lox, LoxL1, LoxL2) were elevated in the oxygen-injured lungs of newborn mice and infants with BPD or at risk for BPD.	Oxygen	127-133	lysyl oxidase-like 1	Mus musculus	92-97
19797161-7	2009	MEASUREMENTS AND MAIN RESULTS: mRNA and protein levels and activity of lysyl oxidases (Lox, LoxL1, LoxL2) were elevated in the oxygen-injured lungs of newborn mice and infants with BPD or at risk for BPD.	Oxygen	127-133	lysyl oxidase-like 2	Mus musculus	99-104
20010384-0	2009	Role of the oxygen-dependent degradation domain in a hypoxia-inducible gene expression system in vascular endothelial growth factor gene therapy.	Oxygen	12-18	vascular endothelial growth factor A	Mus musculus	97-131
19893042-4	2009	Localization of TRAIL(+) cells within the neovascular tufts of hyperoxia- exposed wild-type mice suggested TRAIL plays a role in oxygen-induced retinopathy.	Oxygen	129-135	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	16-21
18952058-5	2008	GPR81 may thus function as a sensor of lactate that can modulate the FFA pool under exercise or conditions of oxygen deficit.	Oxygen	110-116	hydroxycarboxylic acid receptor 1	Homo sapiens	0-5
19007228-1	2008	Tyrosinase catalyzes the biological conversion of tyrosine to dopaquinone with dioxygen at the dinuclear copper active site under physiological conditions.	Oxygen	79-87	tyrosinase	Homo sapiens	0-10
7954662-7	1994	When acetylcholinesterase was incubated with macrophages harvested from rat peritoneum, the rate of oxygen consumption was increased in a concentration-dependent manner that was independent of mitochondrial block with sodium cyanide.	Oxygen	100-106	acetylcholinesterase	Rattus norvegicus	5-25
19073968-9	2008	CONCLUSION: Regulation of CD151 by oxygen tension may play an important role in cancer metastasis by regulating the detachment from the primary site and homing in the secondary site.	Oxygen	35-41	CD151 molecule (Raph blood group)	Homo sapiens	26-31
19893042-4	2009	Localization of TRAIL(+) cells within the neovascular tufts of hyperoxia- exposed wild-type mice suggested TRAIL plays a role in oxygen-induced retinopathy.	Oxygen	129-135	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	107-112
19850349-1	2009	Neuroglobin, a new member of hemoprotein family, can reversibly bind oxygen and take part in many biological processes such as enzymatic reaction, signal transduction and the mitochondria function.	Oxygen	69-75	neuroglobin	Homo sapiens	0-11
18922957-3	2008	In contrast, anoxia exposure (0.01 mg O2/l at 8 degrees C) substantially increased AMPK phosphorylation but decreased AKT phosphorylation in carp heart and brain, indicating activation of AMPK and deactivation of AKT.	Oxygen	38-40	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	83-87
7507506-0	1994	Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.	Oxygen	100-106	apolipoprotein H	Homo sapiens	37-58
18922957-3	2008	In contrast, anoxia exposure (0.01 mg O2/l at 8 degrees C) substantially increased AMPK phosphorylation but decreased AKT phosphorylation in carp heart and brain, indicating activation of AMPK and deactivation of AKT.	Oxygen	38-40	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	188-192
19021508-1	2008	The haem proteins TDO (tryptophan 2,3-dioxygenase) and IDO (indoleamine 2,3-dioxygenase) are specific and powerful oxidation catalysts that insert one molecule of dioxygen into L-tryptophan in the first and rate-limiting step in the kynurenine pathway.	Oxygen	38-46	tryptophan 2,3-dioxygenase	Homo sapiens	18-21
19021508-2	2008	Recent crystallographic and biochemical analyses of TDO and IDO have greatly aided our understanding of the mechanisms employed by these enzymes in the binding and activation of dioxygen and tryptophan.	Oxygen	178-186	tryptophan 2,3-dioxygenase	Homo sapiens	52-55
18805587-0	2008	Coordination changes and auto-hydroxylation of FIH-1: uncoupled O2-activation in a human hypoxia sensor.	Oxygen	64-66	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	47-52
18805587-2	2008	These cellular responses to pO2 are largely controlled by enzymes that belong to the Fe(II) alpha-ketoglutarate (alphaKG) dependent dioxygenase superfamily, including the human enzyme called the factor inhibiting HIF (FIH-1), which couples O2-activation to the hydroxylation of the hypoxia inducible factor alpha (HIFalpha).	Oxygen	29-31	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	218-223
18805587-3	2008	Uncoupled O2-activation by human FIH-1 was studied by exposing the resting form of FIH-1 (alphaKG + Fe)FIH-1, to air in the absence of HIFalpha.	Oxygen	10-12	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	33-38
18939872-3	2008	The formation of furanosyl or cyclopentyl rings is strictly dependent on the presence of unprotected or protected oxygen at C-7 in the starting material.	Oxygen	114-120	complement C7	Homo sapiens	124-127
20045920-0	2009	[Expression of peroxisome proliferator-activated receptor gamma in hippocampus neurons in rats after oxygen deprivation/oxygen supply in vitro].	Oxygen	101-107	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	15-63
20045920-0	2009	[Expression of peroxisome proliferator-activated receptor gamma in hippocampus neurons in rats after oxygen deprivation/oxygen supply in vitro].	Oxygen	120-126	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	15-63
20045920-1	2009	OBJECTIVE: To observe the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in hippocampus neurons in rats after different time of neuron oxygen deprivation/oxygen supply, and to investigate the role of PPARgamma in neuron ischemia reperfusion injury.	Oxygen	163-169	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	40-88
20045920-1	2009	OBJECTIVE: To observe the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in hippocampus neurons in rats after different time of neuron oxygen deprivation/oxygen supply, and to investigate the role of PPARgamma in neuron ischemia reperfusion injury.	Oxygen	163-169	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	90-99
19700645-6	2009	In rat pups exposed to &gt;95% O2 from birth, increased viability induced by intraperitoneal injection of KGF (2 microg/g body wt) every other day was associated with prevention of neutrophil influx in bronchoalveolar lavage (BAL), prevention of decreases in whole lung DNA content and cell proliferation rate, partial prevention of apoptosis increase, and a markedly increased proportion of surfactant protein B-immunoreactive cells in lung parenchyma.	Oxygen	31-33	fibroblast growth factor 7	Rattus norvegicus	106-109
19901551-10	2009	We conclude that hypoxia triggers a feedback mechanism that delays apoptosis of oxygen-deprived malignant intestinal epithelial cells and is driven by hypoxia-induced Beclin 1 downregulation.	Oxygen	80-86	beclin 1	Homo sapiens	167-175
19406206-3	2009	Redox cycling of reduced metabolites of these selenium compounds including selenide with oxygen via TrxR and reduced thioredoxin (Trx) will oxidize NADPH and produce reactive oxygen species inducing cell death at high concentrations explaining selenite toxicity.	Oxygen	89-95	2,4-dienoyl-CoA reductase 1	Homo sapiens	148-153
7507506-8	1994	This epitope is expressed by a conformational change occurring when beta 2-GPI interacts with an oxygen-substituted solid phase surface.	Oxygen	97-103	apolipoprotein H	Homo sapiens	68-78
18937500-1	2008	The flavin-dependent quiescin-sulfhydryl oxidase (QSOX) inserts disulfide bridges into unfolded reduced proteins with the reduction of molecular oxygen to form hydrogen peroxide.	Oxygen	145-151	quiescin sulfhydryl oxidase 1	Homo sapiens	50-54
7541175-0	1994	Critical oxygen extraction in dog hindlimb after inhibition of nitric oxide synthase and cyclooxygenase systems.	Oxygen	9-15	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	89-103
18980986-3	2008	In this report, we show that HIFPH3, a member of prolyl hydroxylases that function as oxygen sensor, is a novel tumor antigen and HIFPH3-specific CTLs are induced from peripheral blood lymphocytes of RCC patients.	Oxygen	86-92	egl-9 family hypoxia inducible factor 3	Homo sapiens	29-35
18980986-3	2008	In this report, we show that HIFPH3, a member of prolyl hydroxylases that function as oxygen sensor, is a novel tumor antigen and HIFPH3-specific CTLs are induced from peripheral blood lymphocytes of RCC patients.	Oxygen	86-92	egl-9 family hypoxia inducible factor 3	Homo sapiens	130-136
19502644-6	2009	Consistent with increased fatty acid utilization, brown adipocytes cultured from Pctp(-/-) mice exhibited higher oxygen consumption rates in response to norepinephrine.	Oxygen	113-119	phosphatidylcholine transfer protein	Mus musculus	81-85
20067108-0	2009	[Effects of endostatin on the expression of Tubulinbeta mRNA in the retina of oxygen-induced retinal neovascularization].	Oxygen	78-84	collagen, type XVIII, alpha 1	Mus musculus	12-22
20067108-1	2009	OBJECTIVE: To investigate the effect of endostatin on the expression of Tubulinbeta in the retina of oxygen-induced retinal neovascularization.	Oxygen	101-107	collagen, type XVIII, alpha 1	Mus musculus	40-50
7597933-1	1994	The myoglobin technique measures oxygen tension in myocytes.	Oxygen	33-39	myoglobin	Homo sapiens	4-13
8186355-6	1994	Endotoxaemic sheep pulmonary dysfunction model: AT III prophylaxis prevents the typical decrease in arterial oxygen partial pressure and AT III prophylaxis combined with alpha 1-proteinase inhibitor significantly attenuates indices of pulmonary dysfunction.	Oxygen	109-115	antithrombin-III	Ovis aries	48-54
19633070-4	2009	Counter to our expectations, however, NK1R-/- animals suffered significantly worse lung injury compared with wild-type mice following exposure to 90% oxygen.	Oxygen	150-156	tachykinin receptor 1	Mus musculus	38-42
18760347-3	2008	It is known that the heme-containing catalytic subunits Nox1 and Nox4 are responsible for oxygen reduction in vascular smooth muscle cells from large arteries.	Oxygen	90-96	NADPH oxidase 1	Rattus norvegicus	56-60
18760347-3	2008	It is known that the heme-containing catalytic subunits Nox1 and Nox4 are responsible for oxygen reduction in vascular smooth muscle cells from large arteries.	Oxygen	90-96	NADPH oxidase 4	Rattus norvegicus	65-69
18760347-12	2008	In contrast, depletion of Nox1 in RASMCs inhibited production of O2*- and AngII-stimulated H2O2 in the membrane fraction and intact cells.	Oxygen	65-67	NADPH oxidase 1	Rattus norvegicus	26-30
18760347-13	2008	Our data suggest that Nox4 produces mainly H2O2, while Nox1 generates mostly O2*- that is later converted to H2O2.	Oxygen	45-47	NADPH oxidase 4	Rattus norvegicus	22-26
18760347-14	2008	Therefore, Nox4 is responsible for basal H2O2 production, while O2*- production in nonstimulated and AngII-stimulated cells depends on Nox1.	Oxygen	43-45	NADPH oxidase 4	Rattus norvegicus	11-15
19576874-8	2009	Serum GGT levels were associated negatively and independently with average arterial oxygen saturation during sleep (P=0.001).	Oxygen	84-90	gamma-glutamyltransferase 1	Homo sapiens	6-9
8924355-6	1994	In addition, administration of recombinant human GM-CSF in vivo (250 mg/M2 per day) for 10 days armed her circulating monocytes as evidenced by increased production of O2- in response to phorbol esther and, when infected ex vivo with M. kansasii, enhanced inhibition of intracellular growth compared with pre-therapy monocytes.	Oxygen	168-170	colony stimulating factor 2	Homo sapiens	49-55
18930820-8	2008	Inclusion of cytochrome b5 in the reconstituted system improved efficiency of oxygen consumption and electron utilization from NADPH, or coupling of the P450 reaction.	Oxygen	78-84	cytochrome b5	Musca domestica	13-26
18586877-14	2008	Increasing oxygen decreased levels of p27(KIP1) in the epithelial cells of older mice, which was prevented by expressing oxygen-insensitive forms of HIF-1alpha.	Oxygen	11-17	cyclin-dependent kinase inhibitor 1B	Mus musculus	38-41
18586877-14	2008	Increasing oxygen decreased levels of p27(KIP1) in the epithelial cells of older mice, which was prevented by expressing oxygen-insensitive forms of HIF-1alpha.	Oxygen	11-17	cyclin-dependent kinase inhibitor 1B	Mus musculus	42-46
18772315-0	2008	Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner.	Oxygen	100-106	FMS-like tyrosine kinase 1	Mus musculus	8-13
19439190-8	2009	These results demonstrate that the F. heteroclitus Ldh-B promoter contains a novel HRE that is capable of driving reporter gene expression in a sequence-specific and oxygen-, time-, and cell line-dependent manner.	Oxygen	166-172	L-lactate dehydrogenase B chain	Fundulus heteroclitus	51-56
19415410-1	2009	BACKGROUND: Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species.	Oxygen	116-122	glutathione peroxidase 1	Homo sapiens	12-36
19415410-1	2009	BACKGROUND: Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species.	Oxygen	116-122	glutathione peroxidase 1	Homo sapiens	38-42
18772315-2	2008	Oxygen concentration-mediated activation of hypoxia-inducible factor targets such as VEGF may serve as the molecular link between the microenvironment and mesoderm-derived blood and endothelial cell specification.	Oxygen	0-6	vascular endothelial growth factor A	Mus musculus	85-89
8146021-0	1994	Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C. To define the role of protein kinase C (PKC) in oxygen-dependent production of erythropoietin (EPO) in the liver, we have determined EPO messenger ribonucleic acid (mRNA) expression in primary cultures of juvenile rat hepatocytes incubated at different oxygen tensions in the absence and presence of phorbol esters, vasopressin, and structurally different kinase inhibitors.	Oxygen	158-164	erythropoietin	Rattus norvegicus	189-203
18772315-5	2008	Parallel measurements of VEGF and VEGFRs demonstrated that sFlt-1 regulates VEGFR2 (Flk-1) activation in both a developmental-stage-dependent and oxygen-dependent manner.	Oxygen	146-152	FMS-like tyrosine kinase 1	Mus musculus	59-65
19541378-14	2009	DynLRB1 was found to be upregulated in FaDu(DD) at both 1% and 0% oxygen.	Oxygen	66-72	dynein light chain roadblock-type 1	Homo sapiens	0-7
18706486-10	2008	The abolition of Fos protein expression evoked by hypoxia suggested that caffeine exposure may decrease the activity of O2-sensing peripheral chemoreceptor pathway.	Oxygen	120-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-20
8146021-1	1994	Upon reduction of oxygen concentrations from 40% to 3% EPO mRNA in cultured hepatocytes increased markedly within 1.25 h, reached maximal values after 2.5 h and remained elevated for up to 72 h. Treatment of hepatocytes during 1.25-5 h of hypoxic exposure with phorbol 12-myristate-13 acetate (PMA) attenuated hypoxia-induced EPO mRNA levels dose-dependently by a maximum of approximately 50%.	Oxygen	18-24	erythropoietin	Rattus norvegicus	55-58
8146021-1	1994	Upon reduction of oxygen concentrations from 40% to 3% EPO mRNA in cultured hepatocytes increased markedly within 1.25 h, reached maximal values after 2.5 h and remained elevated for up to 72 h. Treatment of hepatocytes during 1.25-5 h of hypoxic exposure with phorbol 12-myristate-13 acetate (PMA) attenuated hypoxia-induced EPO mRNA levels dose-dependently by a maximum of approximately 50%.	Oxygen	18-24	erythropoietin	Rattus norvegicus	326-329
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	nuclear receptor subfamily 4 group A member 2	Homo sapiens	162-167
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	solute carrier family 6 member 3	Homo sapiens	179-199
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	194-196	calcium-sensing receptor	Rattus norvegicus	107-110
8144352-0	1993	Hb Howick [beta 37(C3)Trp--&gt;Gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact.	Oxygen	48-54	adrenoceptor alpha 1D	Homo sapiens	79-86
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	194-196	calcium-sensing receptor	Rattus norvegicus	187-190
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	233-235	calcium-sensing receptor	Rattus norvegicus	107-110
18684886-6	2008	Similarly, inhibition of either Gq, Gi, PKC, or CaN, which are components of the mechanism associated with CaR-stimulated COX-2-derived PGE2 synthesis, reversed the inhibitory effects of CaR on O2 consumption without affecting basal O2 consumption.	Oxygen	233-235	calcium-sensing receptor	Rattus norvegicus	187-190
18692496-6	2008	Marked up-regulation of heme oxygenase-1 (HO-1) was detected in both NRK and INS-1 cells when cultured in 3% oxygen.	Oxygen	29-35	heme oxygenase 1	Rattus norvegicus	42-46
19463914-7	2009	Lowered O(2) significantly induced mRNA expression of erythropoietin (EPO) and P27, which affect neuronal differentiation, and was accompanied by upregulation of Nurr1, Pitx3 and dopamine transporter (DAT) mRNAs, which are correlated to the maturation of dopaminergic neurons.	Oxygen	8-12	solute carrier family 6 member 3	Homo sapiens	201-204
19546213-2	2009	Whereas PHD1 and PHD3 proteolysis has been shown to be regulated by Siah2 ubiquitin E3 ligase-mediated polyubiquitylation and proteasomal destruction, protein regulation of the main oxygen sensor responsible for hypoxia-inducible factor alpha regulation, PHD2, remained unknown.	Oxygen	182-188	egl-9 family hypoxia inducible factor 3	Homo sapiens	17-21
8275502-1	1993	2,6-Dihydropyran-3-ones carrying substituents at C-2 and C-6 in cis-arrangement invariably adopt half-chair conformations in which the ring oxygen and the carbon atom next to the carbonyl group are above and below, respectively, the plane formed by the other four carbon atoms, i.e., the 2Ho or oH2 conformation.	Oxygen	140-146	complement C2	Homo sapiens	49-52
19843007-7	2009	GCM1 protein was detectable at low levels in explants maintained for 7 h in 8 or 20% O2.	Oxygen	85-87	glial cells missing transcription factor 1	Homo sapiens	0-4
19843007-8	2009	A striking increase in GCM1 was observed when villous explants were incubated for 1h in 1% O2 (p &lt; 0.002).	Oxygen	91-93	glial cells missing transcription factor 1	Homo sapiens	23-27
19843007-9	2009	Incubation of explants for 1 h in 1% O(2) followed by re-oxygenation for 6 h in 8 or 20% O2 resulted in a decline in GCM1 protein.	Oxygen	37-41	glial cells missing transcription factor 1	Homo sapiens	117-121
19843007-9	2009	Incubation of explants for 1 h in 1% O(2) followed by re-oxygenation for 6 h in 8 or 20% O2 resulted in a decline in GCM1 protein.	Oxygen	89-91	glial cells missing transcription factor 1	Homo sapiens	117-121
19447897-6	2009	We observed that HSP60, although not inducing neutrophil release of ROS and degranulation itself, strongly enhanced the production of reactive oxygen induced by PMA and the release of primary granule enzymes induced by both secondary stimuli.	Oxygen	143-149	heat shock protein family D (Hsp60) member 1	Homo sapiens	17-22
18644622-3	2008	Consequently, CART knockdown exacerbated neuronal cell death induced by oxygen and glucose deprivation (OGD).	Oxygen	72-78	CART prepropeptide	Mus musculus	14-18
19024458-1	2008	P50 is an important parameter reflecting the binding and releasing oxygen properties of blood substitutes.	Oxygen	67-73	secernin 1	Bos taurus	0-3
18769544-6	2008	Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gammadelta and alphabeta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB) dysfunction and hypothermia.	Oxygen	12-18	CD4 antigen	Mus musculus	159-162
7511110-7	1993	Expression of the major histocompatibility complex H-2K was elevated above and below physiological oxygen tension, indicating regulatory processes optimizing MHC expression at about physiological oxygen tension.	Oxygen	99-105	histocompatibility 2, K1, K region	Mus musculus	51-55
18375516-6	2008	Moreover, crystallizing UOX in the presence of a large excess of chloride (NaCl) shows that one chloride ion goes at the same location as the oxygen.	Oxygen	142-148	urate oxidase (pseudogene)	Homo sapiens	24-27
18590811-0	2008	Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases.	Oxygen	9-15	integrin subunit alpha M	Homo sapiens	36-41
18574250-1	2008	This study provides a detailed description of immunolocalization of two oxygen-binding proteins, neuroglobin (Ngb) and cytoglobin (Cygb), in the anterior segment of healthy human and canine eyes.	Oxygen	72-78	neuroglobin	Homo sapiens	97-108
18574250-1	2008	This study provides a detailed description of immunolocalization of two oxygen-binding proteins, neuroglobin (Ngb) and cytoglobin (Cygb), in the anterior segment of healthy human and canine eyes.	Oxygen	72-78	neuroglobin	Homo sapiens	110-113
18644387-1	2008	Hyperbaric oxygen preconditioning (HBO-PC) increases the level of HIF-1alpha (hypoxia inducible factor-1alpha) and its target gene VEGF (vascular endothelial growth factor) which is involved in angiogenesis.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	66-76
18644387-1	2008	Hyperbaric oxygen preconditioning (HBO-PC) increases the level of HIF-1alpha (hypoxia inducible factor-1alpha) and its target gene VEGF (vascular endothelial growth factor) which is involved in angiogenesis.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	78-109
18538129-3	2008	Compared to adult samples, JMJD1A was increased in most tissues of human fetuses in whom oxygen supply is low compared to postnatal levels.	Oxygen	89-95	lysine demethylase 3A	Homo sapiens	27-33
18592129-8	2008	The consequent slowing of the heart rate induced by VVS may constitute a beneficial break of the cardiac pump, thereby reducing myocardial oxygen consumption.	Oxygen	139-145	VVS	Homo sapiens	52-55
18506083-6	2008	Although the expression levels of the PPARgamma target genes involved in lipid metabolism, such as aP2 and stearoyl-CoA desaturase 1, were upregulated in the white adipose tissue of the S112A mice, the serum levels of free fatty acid, triglyceride, adiponectin and leptin, as well as the oxygen consumption, were comparable between the wild-type and S112A mice under the HFD condition.	Oxygen	288-294	stearoyl-Coenzyme A desaturase 1	Mus musculus	107-132
18576623-10	2008	Altogether, this study illustrates the oxidizing power of a [CuO2](+) adduct and substantiates a mechanism by which copper mono-oxygenases such as DbetaH and PHM activate O2 at the Cu(M) center to produce such an intermediate capable of C-H breaking before the electron input provided by the noncoupled Cu(H) center.	Oxygen	63-65	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	158-161
18576597-10	2008	Two stereoisomers affording the syn (4-P syn) and anti (4-P anti) location of the H(9) atom with respect to the oxygen atom of the PO unit have been identified by (1)H NMR.	Oxygen	112-118	syntrophin gamma 1	Homo sapiens	32-44
18576613-0	2008	On the quest for new mixed-metal mu-oxo-bridged complexes: synthesis of compounds containing transition metal-oxygen-main group metal motifs M-O-M1 (M = Ti, Zr; M1 = Al, Ga) without cyclopentadienyl ligands.	Oxygen	110-116	phospholipase A2 group IIA	Homo sapiens	141-147
18638417-1	2008	BACKGROUND: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation.	Oxygen	106-112	urate oxidase (pseudogene)	Homo sapiens	41-44
18424617-1	2008	The myeloperoxidase (MPO)-hydrogen peroxide-halide system is an efficient oxygen-dependent antimicrobial component of polymorphonuclear leukocyte (PMN)-mediated host defense.	Oxygen	74-80	myeloperoxidase	Mus musculus	4-19
18424617-1	2008	The myeloperoxidase (MPO)-hydrogen peroxide-halide system is an efficient oxygen-dependent antimicrobial component of polymorphonuclear leukocyte (PMN)-mediated host defense.	Oxygen	74-80	myeloperoxidase	Mus musculus	21-24
18406335-7	2008	This preliminary result paves the way to experiments aimed at the characterization of pentacoordinate ferrous Ngb, the only species competent in binding external ligands such as O2, CO or NO.	Oxygen	178-180	neuroglobin	Homo sapiens	110-113
18584368-6	2008	RESULTS: The remainder spectrum appears to be a methemoglobin variant quantitatively dependant on the amount of hydroxocobalamin added to the hemoglobin solution and the presence of oxygen.	Oxygen	182-188	hemoglobin subunit gamma 2	Homo sapiens	48-61
18302236-3	2008	Cells expanded at 1.5% O2 were characterized by low citrate synthase (aerobic energy metabolism)--and high LDH (anaerobic energy metabolism-activities,suggesting an anaerobic energy metabolism.	Oxygen	23-25	LDH	Bos taurus	107-110
18798505-5	2008	CONCLUSION: The expression of NGB in human nervous tissues, some endocrine tissues and genital system suggested that NGB might play an important role in the utilizations of oxygen and physiological functions.	Oxygen	173-179	neuroglobin	Homo sapiens	30-33
18798505-5	2008	CONCLUSION: The expression of NGB in human nervous tissues, some endocrine tissues and genital system suggested that NGB might play an important role in the utilizations of oxygen and physiological functions.	Oxygen	173-179	neuroglobin	Homo sapiens	117-120
18535659-3	2008	This approach led to the identification of the mmaA4 gene, which encodes a methyl transferase required for introducing the distal oxygen-containing modifications of mycolic acids, as a key locus involved in the repression of IL-12p40.	Oxygen	130-136	interleukin 12b	Mus musculus	225-233
18157663-7	2008	A drop of the phosphate buffer solution with the AsA was put on the sensing area of the oxygen electrode, and the FMO-3 immobilized membrane was placed on the oxygen electrode and covered with a supporting Nylon mesh net which was secured with a silicone O-ring.	Oxygen	159-165	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	114-119
18459144-5	2008	On the basis of this observation, the present study was performed to verify the involvement of HIF-1, and in particular the effect of chemical and environmental induction of HIF-1alpha (the oxygen sensitive isoform) accumulation in 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR, the key and rate limiting enzyme of cholesterol biosynthetic pathway) regulation.	Oxygen	190-196	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	232-279
18266932-3	2008	In this study, we demonstrated that glucose up-regulated the expression of HIF-1alpha, the oxygen-dependent subunit of HIF-1, in rat primary cortical neurons exposed to hypoxia.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	75-85
18424170-6	2008	Steady state kinetic data show that purified rMAOB exhibits a K(m)(amine) of 176 +/- 15 microM and a k(cat) of 497 +/- 83 min(-1) for benzylamine oxidation, and a K(m)(O2) of 170 +/- 10 microM.	Oxygen	168-170	monoamine oxidase B	Rattus norvegicus	45-50
32038783-6	2008	The facts (i) that many dioxygenases commonly use molecular oxygen and reducing agents during detoxification of xenobiotics, (ii) that detoxification reaction produces radicals and reactive oxygen species, and (iii) that activities of both PHD and FIH-1 are regulated by the changes in the balance between oxygen species and reducing agents, imply the possibility that the activity of HIF-alpha can be increased during detoxification process.	Oxygen	26-32	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	248-253
18418381-0	2008	Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.	Oxygen	0-6	OFD1 centriole and centriolar satellite protein	Homo sapiens	55-59
18418381-5	2008	Ofd1, an uncharacterized prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase, accelerates Sre1N degradation in the presence of oxygen.	Oxygen	75-81	OFD1 centriole and centriolar satellite protein	Homo sapiens	0-4
18418381-6	2008	However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and the Ofd1 C-terminal domain accelerates Sre1N degradation.	Oxygen	152-158	OFD1 centriole and centriolar satellite protein	Homo sapiens	92-96
18418381-6	2008	However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and the Ofd1 C-terminal domain accelerates Sre1N degradation.	Oxygen	182-188	OFD1 centriole and centriolar satellite protein	Homo sapiens	164-168
18418381-6	2008	However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and the Ofd1 C-terminal domain accelerates Sre1N degradation.	Oxygen	182-188	OFD1 centriole and centriolar satellite protein	Homo sapiens	164-168
18418381-7	2008	Our data support a model whereby the Ofd1 N-terminal dioxygenase domain is an oxygen sensor that regulates the activity of the C-terminal degradation domain.	Oxygen	55-61	OFD1 centriole and centriolar satellite protein	Homo sapiens	37-41
18426226-5	2008	Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine.	Oxygen	10-16	monoamine oxidase B	Homo sapiens	156-161
18426226-5	2008	Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine.	Oxygen	76-78	monoamine oxidase B	Homo sapiens	156-161
18477695-4	2008	Activation of hif-1 by hypoxia or by mutations in its negative regulator egl-9/prolyl hydroxylase shifts behavioral oxygen preferences to lower concentrations and eliminates a regulatory input from food.	Oxygen	116-122	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	73-78
19493169-3	2009	In this study, we investigated the hypothesis that NADPH oxidase (Nox) and/or xanthine oxidase serve as critical intermediaries between increased tissue oxygen and the generation of excessive reactive oxygen species that cause oxidative damage to cones.	Oxygen	153-159	xanthine dehydrogenase	Mus musculus	78-94
19470375-2	2009	Here we analyzed the expression of lipocalin-type prostaglandin D synthase (L-PGDS) in the heart of C57BL/6 mice kept under normobaric hypoxia (10% O2) that generates hemodynamic stress.	Oxygen	148-150	prostaglandin D2 synthase (brain)	Mus musculus	35-74
19569635-10	2009	We found that the most active enantiomer is (S) tabun with the cyano group syn to the oxygen of Ser203.	Oxygen	86-92	synemin	Homo sapiens	75-78
19446572-6	2009	In candesartan, carboxylic group, tetrazole ring, and ethoxy group oxygen possibly interact with Lys199 of TM5, Ser109 of TM3 and Asn295 of TM7 and Gln257 of TM6, respectively.	Oxygen	67-73	tropomyosin 3	Homo sapiens	107-110
19446572-6	2009	In candesartan, carboxylic group, tetrazole ring, and ethoxy group oxygen possibly interact with Lys199 of TM5, Ser109 of TM3 and Asn295 of TM7 and Gln257 of TM6, respectively.	Oxygen	67-73	tropomyosin 3	Homo sapiens	122-125
19473970-0	2009	FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells.	Oxygen	17-23	TNF receptor superfamily member 1B	Homo sapiens	49-81
19473970-11	2009	We conclude that FOXO3a regulates oxygen-dependent changes in expression of TNFR2 in HDMECs, controlling sensitivity to TNF-mediated apoptosis.	Oxygen	34-40	TNF receptor superfamily member 1B	Homo sapiens	76-81
19466729-4	2009	ARP-Pt 4 was found to catalyze the aerobic oxidation of a wide variety of alcohols, including non-activated aliphatic and alicyclic alcohols, in water with atmospheric oxygen or air under heterogeneous conditions, and was reused without loss of its catalytic activity, to achieve a highly environmentally-friendly reaction.	Oxygen	168-174	arginine-glutamic acid dipeptide repeats	Homo sapiens	0-3
19584355-0	2009	Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.	Oxygen	0-6	egl-9 family hypoxia inducible factor 3	Homo sapiens	62-67
19488048-9	2009	The potent anorexigenic effects of CRF were accompanied by a prolonged increase in activity, whereas NMU injection resulted in significant but short-lasting inhibition of food intake, ambulatory activity and oxygen consumption.	Oxygen	208-214	neuromedin U	Rattus norvegicus	101-104
19617227-3	2009	As metHb cannot carry oxygen, clinical sequelae result when the concentration of metHb is high enough to compromise oxygen delivery to the tissues.	Oxygen	22-28	hemoglobin subunit gamma 2	Homo sapiens	81-86
19617227-3	2009	As metHb cannot carry oxygen, clinical sequelae result when the concentration of metHb is high enough to compromise oxygen delivery to the tissues.	Oxygen	116-122	hemoglobin subunit gamma 2	Homo sapiens	3-8
19617227-3	2009	As metHb cannot carry oxygen, clinical sequelae result when the concentration of metHb is high enough to compromise oxygen delivery to the tissues.	Oxygen	116-122	hemoglobin subunit gamma 2	Homo sapiens	81-86
19267423-2	2009	Recent studies have implicated Rac1 in cytoskeletal abnormalities, production of reactive oxygen species, and generation of the amyloid beta-peptide (Abeta) observed in Alzheimer"s disease.	Oxygen	90-96	Rac family small GTPase 1	Homo sapiens	31-35
19364672-6	2009	The increased transcripts of Dusp1 following asphyxia suppressed oxygen consumption.	Oxygen	65-71	dual specificity phosphatase 1	Mus musculus	29-34
19364672-13	2009	We thought that the increasing TSC22d3 may lead to the suppression of oxygen consumption to avoid wasting energy, as in proliferation, the same as the increase in Dusp1.	Oxygen	70-76	TSC22 domain family, member 3	Mus musculus	31-38
19225868-1	2009	It was decided to study the effect of glucose deprivation on collagen synthesis and degradation in fibroblast cultures and a correlation of these processes with the expression of oxygen/glucose regulated proteins (ORP150/GRP170).	Oxygen	179-185	hypoxia up-regulated 1	Homo sapiens	214-220
19225868-1	2009	It was decided to study the effect of glucose deprivation on collagen synthesis and degradation in fibroblast cultures and a correlation of these processes with the expression of oxygen/glucose regulated proteins (ORP150/GRP170).	Oxygen	179-185	hypoxia up-regulated 1	Homo sapiens	221-227
19287337-0	2009	Down-regulation of hypoxia-inducible factor-1alpha by hyperbaric oxygen attenuates the severity of acute pancreatitis in rats.	Oxygen	65-71	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	19-50
19650992-7	2009	RESULTS: Compared with the control group, the 3% and 5% oxygen treatment groups significantly increased the adhesion, migration and invasion abilities of K562 cells (p&lt;0.05 or &lt;0.01), and up-regulated the protein level of HIF-1alpha and the mRNA levels of HIF-1alpha,VEGF, MMP-9 and MMP-2 (p&lt;0.05 or 0.01).	Oxygen	56-62	matrix metallopeptidase 9	Homo sapiens	279-284
19397338-13	2009	Thus, catalysis involves a flow of reducing equivalents from the reduced CxC motif of Mia40 to distal and then proximal CxxC motifs of lfALR to the flavin ring and, finally, to cytochrome c or molecular oxygen.	Oxygen	203-209	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	86-91
19384202-12	2009	Compared with hetastarch infusion alone, the addition of NHE-1 inhibitor improved the hemodynamic response to fluid resuscitation, increased blood oxygen content, prevented metabolic acidosis, and improved 6-hour survival (42% in hetastarch group vs. 80% in BIIB513 + hetastarch group).	Oxygen	147-153	solute carrier family 9 member A1	Rattus norvegicus	57-62
19185026-9	2009	Overall, mutant ataxin-3 may influence the activity of enzymatic components to remove O(2)(-) and H(2)O(2) efficiently and promote mitochondrial DNA damage or depletion, which leads to dysfunction of mitochondria.	Oxygen	86-90	ataxin 3	Homo sapiens	16-24
19443591-11	2009	The fact that skeletal muscles but not tendons showed upregulation of HIF1alpha and CAIII could indicate that healthy tendons are less responsive than skeletal muscles to low levels of oxygen.	Oxygen	185-191	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	70-79
19443591-11	2009	The fact that skeletal muscles but not tendons showed upregulation of HIF1alpha and CAIII could indicate that healthy tendons are less responsive than skeletal muscles to low levels of oxygen.	Oxygen	185-191	carbonic anhydrase 3	Rattus norvegicus	84-89
19293391-2	2009	Here, we examined the effects of edaravone on the dynamics of high-mobility group box-1 (HMGB1), which is a key mediator of ischemic-induced brain damage, during a 48-h postischemia/reperfusion period in rats and in oxygen-glucose-deprived (OGD) PC12 cells.	Oxygen	216-222	high mobility group box 1	Rattus norvegicus	89-94
19357551-6	2009	As opposed to other current gauges of hypoxia, ODF is a local and sensitive measure of both the extent and severity of corneal oxygen deprivation.	Oxygen	127-133	TNF superfamily member 11	Homo sapiens	47-50
19262507-8	2009	The effect of the glb-5 gene on oxygen sensing and foraging is modified by the naturally variable neuropeptide receptor npr-1 (refs 4, 5), providing insights into how polygenic variation reshapes neural circuit function.	Oxygen	32-38	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	120-125
19179331-3	2009	Initial studies revealed that yeast cells deleted in ISC1, the gene encoding inositol sphingolipid phospholipase C, which resides in mitochondria in the post-diauxic phase, showed defective aerobic respiration in the post-diauxic phase but retained normal intrinsic mitochondrial functions, including intact mitochondrial DNA, normal oxygen consumption, and normal mitochondrial polarization.	Oxygen	334-340	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	53-57
19194461-5	2009	We provide evidence that the loss of Jhdm2a function disrupts beta-adrenergic-stimulated glycerol release and oxygen consumption in brown fat, and decreases fat oxidation and glycerol release in skeletal muscles.	Oxygen	110-116	lysine (K)-specific demethylase 3A	Mus musculus	37-43
19245230-5	2009	In reactions of O(2) with d(0) 1 and 2, oxidation of the ligands is the prevailing pathway.	Oxygen	16-20	immunoglobulin heavy diversity 2-15	Homo sapiens	26-38
19176352-7	2009	Consistently, the energy expenditure, oxygen consumption, and CO2 production in VDR-null mice were markedly higher than in WT mice.	Oxygen	38-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	80-83
19275153-1	2009	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine.	Oxygen	106-110	tryptophan 2,3-dioxygenase	Homo sapiens	38-64
19275153-1	2009	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine.	Oxygen	106-110	tryptophan 2,3-dioxygenase	Homo sapiens	66-69
19476795-0	2009	Hemoglobin-based oxygen carrier induces heme oxygenase-1 in the heart and lung but not brain.	Oxygen	17-23	heme oxygenase 1	Rattus norvegicus	40-56
19220706-3	2009	Hypoxia (5% O(2)) also activates hypoxia inducible factor (HIF) 1alpha, increasing mRNA, nuclear protein and nuclear protein/hypoxia response element binding complex formation.	Oxygen	12-16	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-70
19372575-3	2009	Siah2 regulates prolyl hydroxylases PHD3 and 1 under oxygen concentration of 2% to 5%, thereby allowing accumulation of hypoxia-inducible factor (HIF)-1alpha, a master regulator of the hypoxia response within the range of physiological normoxic to mild hypoxic conditions.	Oxygen	53-59	siah E3 ubiquitin protein ligase 2	Mus musculus	0-5
19372578-5	2009	As compared with 20%, growth at 7% oxygen resulted in an increase in the expression levels of the neural stem cell markers CD133 and nestin as well as the stem cell markers Oct4 and Sox2.	Oxygen	35-41	SRY-box transcription factor 2	Homo sapiens	182-186
19350103-2	2009	Oxidative stress, through the generation of oxygen metabolites including H(2)O(2), stimulates intracellular ADP-ribose formation which, in turn, opens TRPM2 channels.	Oxygen	44-50	transient receptor potential cation channel subfamily M member 2	Homo sapiens	151-156
19250632-1	2009	It is well established that ozone as well as oxygen activated by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase cleave the 2,3-C=C bond of the indole ring of tryptophan to produce N-formylkynurenine.	Oxygen	45-51	tryptophan 2,3-dioxygenase	Homo sapiens	65-91
18329717-5	2008	Time-resolved UV/vis spectra at low temperatures allowed the spectroscopic detection of dioxygen adduct complexes as reactive intermediates during the oxidation of 1/2 with dioxygen that seem to play an important role in copper enzymes such as peptidylglycine-alpha-hydroxylating monooxygenase (PHM).	Oxygen	88-96	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	244-293
18329717-5	2008	Time-resolved UV/vis spectra at low temperatures allowed the spectroscopic detection of dioxygen adduct complexes as reactive intermediates during the oxidation of 1/2 with dioxygen that seem to play an important role in copper enzymes such as peptidylglycine-alpha-hydroxylating monooxygenase (PHM).	Oxygen	88-96	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	295-298
18469646-0	2008	The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock.	Oxygen	89-95	HGB	Sus scrofa	47-57
18469646-0	2008	The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock.	Oxygen	89-95	HGB	Sus scrofa	72-82
18469646-1	2008	BACKGROUND: Some hemoglobin-based oxygen carriers (HBOCs) improve outcome in animal models of hemorrhagic shock (HS) in comparison with standard asanguinous resuscitation fluids.	Oxygen	34-40	HGB	Sus scrofa	17-27
18255335-0	2008	Spin-trapping of oxygen free radicals in chemical and biological systems: new traps, radicals and possibilities.	Oxygen	17-23	spindlin 1	Homo sapiens	0-4
18405381-7	2008	Moreover, the use of PLB-985 granulocytes in which the NADPH oxidase is inactive due to the targeted disruption of a key component (gp91phox) revealed that NF-kappaB activation and kappaB-dependent responses are independent of endogenous reactive oxygen intermediates in these cells.	Oxygen	247-253	cytochrome b-245 beta chain	Homo sapiens	132-140
18478813-6	2008	Adequate oxygen delivery to the tissues in the body is compromised when MHb overwhelms the capacity of the red blood cells to carry oxygen.	Oxygen	9-15	hemoglobin subunit gamma 2	Homo sapiens	72-75
18478813-6	2008	Adequate oxygen delivery to the tissues in the body is compromised when MHb overwhelms the capacity of the red blood cells to carry oxygen.	Oxygen	132-138	hemoglobin subunit gamma 2	Homo sapiens	72-75
19318315-5	2009	In addition, the stimulation of IL-6 production by IL-17 in MSC cultures and co-cultures is enhanced by low O2 concentration.	Oxygen	108-110	interleukin 17A	Homo sapiens	51-56
19318315-6	2009	The expression of some differentiation markers (CD34, CD13 and CD41) on haematopoietic cells in co-cultures also depends upon the oxygen concentration.	Oxygen	130-136	integrin subunit alpha 2b	Homo sapiens	63-67
7511110-7	1993	Expression of the major histocompatibility complex H-2K was elevated above and below physiological oxygen tension, indicating regulatory processes optimizing MHC expression at about physiological oxygen tension.	Oxygen	196-202	histocompatibility 2, K1, K region	Mus musculus	51-55
8282094-2	1993	In particular, the formation of toxic oxygen metabolites via the NADPH oxidase requires the action of both Rac and Rap1A proteins.	Oxygen	38-44	RAP1A, member of RAS oncogene family	Homo sapiens	115-120
21475804-2	2009	Hypoxia-inducible factor (HIF)-1alpha is the primary transcription factor responsible for regulating cellular response to changes in oxygen tension.	Oxygen	133-139	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-37
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	matrix metallopeptidase 9	Homo sapiens	182-187
19298750-6	2009	CONCLUSION: On a molecular level, hyperbaric oxygen therapy leads to activation of ion channels, inhibition of hypoxia inducible factor-1alpha, up-regulation of Bcl-2, inhibition of MMP-9, decreased cyclooxygenase-2 activity, decreased myeloperoxidase activity, up-regulation of superoxide dismutase and inhibition of Nogo-A (an endogenous growth-inhibitory factor).	Oxygen	45-51	metallothionein 3	Homo sapiens	340-364
18202699-3	2008	The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1alpha (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	75-80
18202699-3	2008	The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1alpha (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription.	Oxygen	182-188	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	75-80
18391643-5	2008	RESULTS: At baseline, in both groups, CNP plasma level was significantly related to BNP (R=0.50), ejection fraction (R=0.43), and peak oxygen uptake (VO2, R=0.43, all P&lt;0.001).	Oxygen	135-141	natriuretic peptide C	Homo sapiens	38-41
19298751-3	2009	RESULTS: Neuroglobin is a recently discovered tissue globin with a high affinity for oxygen and is widely and specifically expressed in neurons of vertebrate"s central and peripheral nervous systems.	Oxygen	85-91	neuroglobin	Homo sapiens	9-20
19298751-7	2009	CONCLUSION: Emerging experimental works suggest that neuroglobin is neuroprotective against hypoxic/ischemic insults, probably via ligand binding and oxygen sensing, modulation of cell signaling pathways and maintenance of mitochondria function.	Oxygen	150-156	neuroglobin	Homo sapiens	53-64
7505764-6	1993	Inhibition of the rise in serum amylase and lipase concentrations by pretreatment with a scavenger of active oxygen, superoxide dismutase, suggests that the active oxygen species are involved in the pathogenesis of acute pancreatitis.	Oxygen	109-115	lipase G, endothelial type	Rattus norvegicus	44-50
18957686-0	2009	CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.	Oxygen	82-88	C-X-C motif chemokine receptor 4	Homo sapiens	0-5
18341590-5	2008	The level of HIF-1alpha mRNA and protein expression detected by RT-PCR and western blot significantly increased in NPCs subjected to 10% O(2).	Oxygen	137-141	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	13-23
18341590-7	2008	We found that overexpression of HIF-1alpha caused the same proliferative effect on NPCs under 20% O(2) as under 10% O(2).	Oxygen	98-102	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	32-42
18341590-7	2008	We found that overexpression of HIF-1alpha caused the same proliferative effect on NPCs under 20% O(2) as under 10% O(2).	Oxygen	116-120	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	32-42
7505764-6	1993	Inhibition of the rise in serum amylase and lipase concentrations by pretreatment with a scavenger of active oxygen, superoxide dismutase, suggests that the active oxygen species are involved in the pathogenesis of acute pancreatitis.	Oxygen	164-170	lipase G, endothelial type	Rattus norvegicus	44-50
18341590-8	2008	In contrast, knockdown of HIF-1alpha inhibited NPC proliferation induced by 10% O(2).	Oxygen	80-84	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	26-36
19128042-8	2009	An unanticipated addition of atmospheric oxygen was encountered during deprotection of the imidazole ring in the last step of the synthesis leading to C-11 oxygenated ceratamine analogues as byproducts.	Oxygen	41-47	RNA polymerase III subunit K	Homo sapiens	151-155
8412126-6	1993	Interleukin-1 alpha (IL-1 alpha), transforming growth factor beta (TGF-beta), and tumor necrosis factor alpha (TNF alpha) stimulated phorbol ester-induced O2- production by resident macrophages in a concentration-dependent manner.	Oxygen	155-157	tumor necrosis factor	Oryctolagus cuniculus	82-109
19284806-8	2009	RESULTS: The ICER for continuous oxygen therapy ($16,124 per quality-adjusted life-year [QALY]) was within bounds considered to be cost-effective, while that of nocturnal oxygen therapy was not ($306,356/QALY).	Oxygen	33-39	cAMP responsive element modulator	Homo sapiens	13-17
19284806-9	2009	The estimated ICER for continuous oxygen therapy was robust (95% confidence interval, $13,153-$24,658/QALY) and was more favorable than the ICERs for commonly used medical and surgical therapies for chronic obstructive pulmonary disease.	Oxygen	34-40	cAMP responsive element modulator	Homo sapiens	14-18
19284806-10	2009	The ICER for nocturnal oxygen therapy was sensitive to variation in the mortality rate; it could be as low as $18,267/QALY gained.	Oxygen	23-29	cAMP responsive element modulator	Homo sapiens	4-8
19143764-7	2009	When cultured at 5% oxygen for either 4 weeks or up to 18 months, high levels of Nanog and Notch1 transcriptional expression were detected, albeit the expression was significantly lower during longer exposure.	Oxygen	20-26	Nanog homeobox	Homo sapiens	81-86
18288871-9	2008	Analysis of the potential dependence of this band in the CO oxidation potential region led us to conclude that this is the oxygen-containing species to oxidize adsorbed CO. Stark tuning rates of nu(CO) bands for the COs at the terrace and step edge sites on both Pt/C and Pt-B are almost independent of the adsorption sites for both atop- and bridge-bonded COs.	Oxygen	123-129	polypyrimidine tract binding protein 1	Homo sapiens	272-276
18303874-10	2008	The exoergicity of O2*- addition to protonated DMPO was rationalized using density functional theory (DFT) at the PCM/B3LYP/6-31+G**//B3LYP/6-31G* level of theory.	Oxygen	19-21	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	120-123
18316022-3	2008	(2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2alpha- and PPARalpha-dependent fashion.	Oxygen	97-103	egl-9 family hypoxia-inducible factor 2	Mus musculus	54-58
8412126-6	1993	Interleukin-1 alpha (IL-1 alpha), transforming growth factor beta (TGF-beta), and tumor necrosis factor alpha (TNF alpha) stimulated phorbol ester-induced O2- production by resident macrophages in a concentration-dependent manner.	Oxygen	155-157	tumor necrosis factor	Oryctolagus cuniculus	111-120
7690756-2	1993	The Apn1 DNA repair enzyme of Saccharomyces cerevisiae acts on abasic sites and oxygen radical damages.	Oxygen	80-86	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	4-8
18245276-2	2008	It has two oxygen-sensitive [Fe-Fe] hydrogenases (EC 1.12.7.2) that are coupled to photosynthesis and, in addition, a formate- and ethanol-producing fermentative metabolism, which was proposed to be initiated by pyruvate formate-lyase (Pfl; EC 2.3.1.54).	Oxygen	11-17	uncharacterized protein	Chlamydomonas reinhardtii	212-234
19383366-2	2009	Neuroglobin expression increases in oxygen-deprived neurons, suggesting it protects neurons from ischemic cell death.	Oxygen	36-42	neuroglobin	Homo sapiens	0-11
8397193-1	1993	Reaction of the modified myoglobin with molecular oxygen.	Oxygen	50-56	myoglobin	Homo sapiens	25-34
19320284-1	2009	The objective of this work was to investigate the effect of oxygen containing terpenes (carvacrol, menthol and carvone) at 5%w/v in hydroalcoholic mixtures (40% ethanol) on the permeation of LHRH across newborn pig skin in vitro.	Oxygen	60-66	gonadotropin-releasing hormone receptor	Sus scrofa	191-195
18160403-6	2008	We report here that FTL and FTH are differentially regulated in 1% oxygen on a post-transcriptional level.	Oxygen	67-73	ferritin light chain	Homo sapiens	20-23
8107685-7	1993	Since G-6-PDH and glutathione reductase are both necessary to regenerate reduced glutathione (GSH) which couples with glutathione peroxidase to breakdown hydrogen peroxide (H2O2) under normal conditions, it is plausible that the oxygen toxicity observed in isolated Leydig cells is due to the intracellular accumulation of H2O2.	Oxygen	229-235	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	6-13
18056839-4	2008	In parallel, vascular permeability was significantly increased in vascular organs of A2BAR(-/-)-mice subjected to ambient hypoxia (8% oxygen, 4 hours; eg, lung: 2.1 +/- 0.12-fold increase).	Oxygen	134-140	adenosine A2b receptor	Mus musculus	85-90
18817143-4	2008	An isolate SS2, selected from a fermented star fruit beverage, survived in the human biological barriers (0.15 and 0.30% bile salt, pH values between 3-8, presence or absence of oxygen), resistance to some antibiotics in general use and showed other benefits to the host (antibacterial activity, utilizations of protein and starch).	Oxygen	178-184	butyrophilin like 2	Homo sapiens	11-14
19119811-7	2009	HYSCORE studies of a peptide analogue with selective (13)C-labeling of Asp1 revealed (13)C cross-peaks characteristic of equatorial coordination by the carboxylate oxygen of Asp1 in component Ia/b coordination.	Oxygen	164-170	beta-secretase 2	Homo sapiens	71-75
19119811-7	2009	HYSCORE studies of a peptide analogue with selective (13)C-labeling of Asp1 revealed (13)C cross-peaks characteristic of equatorial coordination by the carboxylate oxygen of Asp1 in component Ia/b coordination.	Oxygen	164-170	beta-secretase 2	Homo sapiens	174-178
19104049-4	2009	The main effect of DAT1 genotype was seen in robust blood-oxygen-level-dependent response differences in the caudate nucleus and ventral striatum during reward anticipation (P &lt; 0.001) and in the lateral prefrontal cortex and midbrain at the time of reward delivery, with carriers of the DAT1 9-repeat allele showing the highest activity.	Oxygen	58-64	solute carrier family 6 member 3	Homo sapiens	19-23
19104049-4	2009	The main effect of DAT1 genotype was seen in robust blood-oxygen-level-dependent response differences in the caudate nucleus and ventral striatum during reward anticipation (P &lt; 0.001) and in the lateral prefrontal cortex and midbrain at the time of reward delivery, with carriers of the DAT1 9-repeat allele showing the highest activity.	Oxygen	58-64	solute carrier family 6 member 3	Homo sapiens	291-295
8103296-10	1993	In vitro studies revealed that isolated rat peripheral blood monocytes produce O2- in response to MCP 1.	Oxygen	79-81	C-C motif chemokine ligand 2	Rattus norvegicus	98-103
19028555-5	2009	An AhR-activation by 10nM TCDD and HIF-1alpha activation by 5% oxygen induced activation of NFATc1.	Oxygen	63-69	nuclear factor of activated T cells 1	Homo sapiens	92-98
18352314-1	2008	Spin-density-functional calculations of tip-suspended gold chains, with molecular oxygen, or dissociated oxygen atoms, incorporated in them, reveal structural transitions for varying lengths.	Oxygen	82-88	spindlin 1	Homo sapiens	0-4
18352314-1	2008	Spin-density-functional calculations of tip-suspended gold chains, with molecular oxygen, or dissociated oxygen atoms, incorporated in them, reveal structural transitions for varying lengths.	Oxygen	105-111	spindlin 1	Homo sapiens	0-4
8367497-0	1993	Phospholipase A2 activity can protect renal tubules from oxygen deprivation injury.	Oxygen	57-63	phospholipase A2 group IB	Rattus norvegicus	0-16
17765386-7	2008	The p-CREB expression was higher with 100% vs. 21% oxygen resuscitation in the hippocampus (217+/-41% vs. 132+/-30%, p&lt;0.01) with no changes in striatum.	Oxygen	51-57	cAMP responsive element binding protein 1	Homo sapiens	6-10
19101265-2	2009	The INVOS Cerebral Oximeter (Somanetics Corp, Troy, MI) is a Food and Drug Administration approved device that measures regional cerebral oxygen (rSo(2)) saturation.	Oxygen	138-144	TNF receptor superfamily member 19	Homo sapiens	46-50
8367497-9	1993	These results indicate that PLA2 activity can exert both beneficial and deleterious effects on O2-deprived renal tubules, the net result of which can be a salvaging of cells from hypoxic cell death.	Oxygen	95-97	phospholipase A2 group IB	Rattus norvegicus	28-32
19672068-8	2009	Furthermore, hyperoxia induced upregulation of MMP-9 following 12 h of oxygen exposure and this was attenuated by rEpo treatment.	Oxygen	71-77	matrix metallopeptidase 9	Homo sapiens	47-52
8353285-0	1993	Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.	Oxygen	9-15	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-143
19321927-6	2009	RESULTS: Following incubation with cAMP at 21% O(2), peak gene expression of syncytin-1 and GCMa was found after 24 h along with syncytium formation at 72 h. Conversely, incubation at 1% O(2) led to a time-dependent reduction of GCMa and syncytin-1 at the transcriptional level.	Oxygen	47-51	glial cells missing transcription factor 1	Homo sapiens	92-96
19065050-9	2009	These data suggest that VHL/HIF oxygen-sensing mechanisms play a critical role in glucose homeostasis and that activation of this pathway in response to decreased islet oxygenation may contribute to beta cell dysfunction.	Oxygen	32-38	von Hippel-Lindau tumor suppressor	Mus musculus	24-27
18086531-4	2008	Accordingly, the O2-binding ability of the protein increases by short-time UVA irradiation of metHb together with NADH, which corresponds with the reduction of metHb, while it decreases by long-time UVA irradiation, which corresponds with the structural destruction.	Oxygen	17-19	hemoglobin subunit gamma 2	Homo sapiens	94-99
18086531-4	2008	Accordingly, the O2-binding ability of the protein increases by short-time UVA irradiation of metHb together with NADH, which corresponds with the reduction of metHb, while it decreases by long-time UVA irradiation, which corresponds with the structural destruction.	Oxygen	17-19	hemoglobin subunit gamma 2	Homo sapiens	160-165
18234901-14	2008	Postnatal day 3 (P3) and P6 rats, but not P10 pups, showed bilateral reduction in MBP (myelin basic protein) expression with 24 h exposure to 80% oxygen.	Oxygen	146-152	myelin basic protein	Rattus norvegicus	82-85
18234901-14	2008	Postnatal day 3 (P3) and P6 rats, but not P10 pups, showed bilateral reduction in MBP (myelin basic protein) expression with 24 h exposure to 80% oxygen.	Oxygen	146-152	myelin basic protein	Rattus norvegicus	87-107
17935968-4	2008	To facilitate the electrochemical communication between the CNT layer and GOx, CNT was treated with nitrogen or oxygen plasma.	Oxygen	112-118	hydroxyacid oxidase 1	Homo sapiens	74-77
18626794-3	2009	As there is only scarce evidence for a genetic linkage between synaptophysin"s chromosomal locus (Xp11.22) and schizophrenia, we hypothesized that early neonatal exposure of rat pups to oxygen restriction would result in reduced frontal cortex synaptophysin protein levels at adulthood.	Oxygen	186-192	synaptophysin	Rattus norvegicus	63-76
8353285-0	1993	Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.	Oxygen	9-15	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-154
18626794-3	2009	As there is only scarce evidence for a genetic linkage between synaptophysin"s chromosomal locus (Xp11.22) and schizophrenia, we hypothesized that early neonatal exposure of rat pups to oxygen restriction would result in reduced frontal cortex synaptophysin protein levels at adulthood.	Oxygen	186-192	synaptophysin	Rattus norvegicus	244-257
8399772-3	1993	The ability of TR-RED to protect the skin from UV-generated free oxygen species has been found.	Oxygen	65-71	peroxiredoxin 5	Homo sapiens	15-21
19082468-0	2009	Oxygen-dependent regulation of NDRG1 in human glioblastoma cells in vitro and in vivo.	Oxygen	0-6	N-myc downstream regulated 1	Homo sapiens	31-36
17938254-10	2008	The release of s-HJV might be a tissue-specific mechanism, signaling the local iron requests of hypoxic skeletal muscles independently of the oxygen status of the liver.	Oxygen	142-148	hemojuvelin BMP co-receptor	Mus musculus	17-20
8400799-2	1993	Pulse oximeters, using only 2 wavelengths, are designed for the continuous noninvasive measurement of the arterial partial O2 saturation (psO2, %) in vivo.	Oxygen	123-125	DNA cross-link repair 1A	Homo sapiens	138-142
17934062-2	2008	Prolonged mechanical ventilation (MV) with O2-rich gas inhibits lung growth and causes excess, disordered accumulation of lung elastin in preterm infants, often resulting in chronic lung disease (CLD).	Oxygen	43-45	elastin	Homo sapiens	127-134
19161405-5	2009	This is about an order of magnitude lower than the singlet-oxygen quenching constants for (GRP)(2)-canthaxanthin in various organic solvents.	Oxygen	59-65	gastrin releasing peptide	Homo sapiens	91-94
19161405-7	2009	The singlet-oxygen quenching constant for (GRP)(2)-canthaxanthin in micelles depends strongly on the specific detergent used, varying from 9.4 x 10(8) m(-1)s(-1) for hexadecyltrimethylammonium bromide (CTAB) to 1.24 +/- 0.4 x 10(10) m(-1)s(-1) for sodium dodecyl sulfate.	Oxygen	12-18	gastrin releasing peptide	Homo sapiens	43-46
19357789-4	2009	In addition, event-related fMRI data reveal that, when a dot subjectively reappears during MIB, the blood oxygen-level dependent (BOLD) signal increases in V1v and V2v and decreases in contralateral hMT+.	Oxygen	106-112	histamine N-methyltransferase	Homo sapiens	199-202
18680118-0	2008	Spin state, structure, and reactivity of terminal oxo and dioxygen complexes of the (PNP)Rh moiety.	Oxygen	58-66	spindlin 1	Homo sapiens	0-4
8412088-7	1993	During 13% FIO2, animals with high P50 showed a fall in cardiac output and oxygen consumption while animals with normal P50 remained stable.	Oxygen	75-81	Y-box-binding protein 1	Oryctolagus cuniculus	35-38
19001220-1	2008	OBJECTIVE: To determine the distribution of 2 intracellular oxygen-carrying molecules, neuroglobin (NGB) and cytoglobin (CYGB), in specific retinal cell types of human retinas.	Oxygen	60-66	neuroglobin	Homo sapiens	87-98
19001220-1	2008	OBJECTIVE: To determine the distribution of 2 intracellular oxygen-carrying molecules, neuroglobin (NGB) and cytoglobin (CYGB), in specific retinal cell types of human retinas.	Oxygen	60-66	neuroglobin	Homo sapiens	100-103
18511861-2	2008	This robust oxygen consumption is related to a superoxide-generating enzyme, the phagocytic NADPH oxidase (Nox2-based or phox).	Oxygen	12-18	cytochrome b-245 beta chain	Homo sapiens	107-111
8506320-0	1993	Oxygen toxicity in a polyamine-depleted spe2 delta mutant of Saccharomyces cerevisiae.	Oxygen	0-6	adenosylmethionine decarboxylase SPE2	Saccharomyces cerevisiae S288C	40-44
18190518-0	2008	5-HT(2C) antagonism blocks blood oxygen level-dependent pharmacological-challenge magnetic resonance imaging signal in rat brain areas related to feeding.	Oxygen	33-39	5-hydroxytryptamine receptor 2C	Rattus norvegicus	0-7
18929647-5	2008	The western blot analysis showed that treatment with 1% O2 for 0.5 or 3 h also induced a significant increase in the expression of bystin and that the response of bystin to mild ischemia was much more sensitive than that of GFAP.	Oxygen	56-58	glial fibrillary acidic protein	Homo sapiens	224-228
8506320-1	1993	When a mutant of Saccharomyces cerevisiae (spe2 delta) that cannot make spermidine or spermine was incubated in a polyamine-deficient medium in oxygen, there was a rapid cessation of cell growth and associated cell death.	Oxygen	144-150	adenosylmethionine decarboxylase SPE2	Saccharomyces cerevisiae S288C	43-47
18464252-8	2008	The results achieved are promising for the fabrication of blood substitutes with controlled metHb level, which can fulfill the binding/delivering oxygen to tissues in vivo for future trials.	Oxygen	146-152	hemoglobin subunit gamma 2	Homo sapiens	92-97
20732191-3	1993	Metabolites derived from side-chain oxidation accounted for 90-95% of the 2,6-DNT metabolites produced by rat liver slices under ambient oxygen concentrations of 25-100%; however, under 0% oxygen (100% nitrogen) atmospheres 2-amino-6-nitrotoluene accounted for 96% of the total metabolites.	Oxygen	137-143	5', 3'-nucleotidase, cytosolic	Homo sapiens	78-81
19082413-1	2008	BACKGROUND AND OBJECTIVES: Methemoglobin is the oxidized form of hemoglobin, which does not bind oxygen and increases the affinity of oxygen for the partially oxidized portion of hemoglobin.	Oxygen	134-140	hemoglobin subunit gamma 2	Homo sapiens	27-40
18927305-0	2008	Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.	Oxygen	22-28	egl-9 family hypoxia inducible factor 3	Homo sapiens	51-56
18927305-2	2008	Our aim was to assess the expression of proteins that act as cellular oxygen sensors, directly regulating the hypoxia inducible factor (HIF) pathway, i.e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET).	Oxygen	70-76	egl-9 family hypoxia inducible factor 3	Homo sapiens	207-212
18775698-2	2008	The AlkB family proteins utilize iron(II), alpha-ketoglutarate (alpha-KG) and dioxygen to perform oxidative repair of alkylated nucleobases in DNA and RNA.	Oxygen	78-86	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-8
18374171-6	2008	Data show that Rho GTPases RhoA and Rac1 regulate pulmonary endothelial barrier function in response to changes in oxygen tension.	Oxygen	115-121	Rac family small GTPase 1	Homo sapiens	36-40
17712632-0	2008	Rapid decrease of GAD 67 content before the convulsion induced by hyperbaric oxygen exposure.	Oxygen	77-83	glutamate decarboxylase 1	Homo sapiens	18-24
17725546-2	2007	The activity of these transcription factors is mainly determined by the stability of the HIFalpha subunit, which is regulated, in an oxygen-dependent manner, by a family of three prolyl 4-hydroxylases [EGLN1-EGLN3 (EGL nine homologues 1-3)].	Oxygen	133-139	egl-9 family hypoxia inducible factor 3	Homo sapiens	208-213
18833277-2	2008	The pivotal early Oligocene event is characterized by a rapid shift of 1.5 parts per thousand in deep-sea benthic oxygen-isotope values (Oi-1) within a few hundred thousand years, reflecting a combination of terrestrial ice growth and deep-sea cooling.	Oxygen	114-120	collagen type I alpha 1 chain	Homo sapiens	137-141
17459749-3	2007	We measured lung (VO2(lung)) and CAM (VO2(CAM)) oxygen consumption independently before and after 60 min exposure to combinations of hypoxia, hyperoxia, and normoxia to the air cell and the remaining egg.	Oxygen	48-54	calmodulin 2	Gallus gallus	38-46
8387598-3	1993	Introduction of alkyl groups at N-1 or C-4 oxygen led to inactive compounds (35-43 and 50).	Oxygen	43-49	complement C4A (Rodgers blood group)	Homo sapiens	39-42
17459749-5	2007	In response to the different O2 treatments, a change in VO2(lung) was compensated by an inverse change in VO2(CAM) of similar magnitude.	Oxygen	29-31	calmodulin 2	Gallus gallus	106-114
18052446-6	2007	The effect of C(O) on alpha(H(2) ) is explained by the presence of oxygen-free sites (holes in coverage) serving as active centers of the surface reaction in the oxygen monolayer upon Nb.	Oxygen	67-73	relaxin 2	Homo sapiens	22-32
18052446-6	2007	The effect of C(O) on alpha(H(2) ) is explained by the presence of oxygen-free sites (holes in coverage) serving as active centers of the surface reaction in the oxygen monolayer upon Nb.	Oxygen	162-168	relaxin 2	Homo sapiens	22-32
18850054-2	2008	As an oxygen-sensitive attenuator, factor inhibiting HIF-1 (FIH) hydroxylates a conserved asparagine residue within the C-terminal transactivation domain of HIF-1alpha under normoxia and moderate hypoxia.	Oxygen	6-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	157-167
8479293-4	1993	In vitro analysis has demonstrated that heme is capable of specific attachment to brain spectrin, suggesting possible new functions in electron transfer, oxygen binding, nitric oxide binding or heme scavenging.	Oxygen	154-160	spectrin beta, non-erythrocytic 1	Mus musculus	82-96
18551145-4	2008	Stable MDA-MB-435 cells expressing the chimeric therapeutic gene under 1% O2 showed an increase in stable HIF-1alpha protein levels and synthesis of the endonuclease G protein in a time-dependent manner.	Oxygen	74-76	endonuclease G	Homo sapiens	153-167
8428969-2	1993	This was shown in experiments in which oxygen consumption was measured during redox cycling of the altered myoglobin in the presence of ascorbate or an enzymatic reducing system containing diaphorase and NADH.	Oxygen	39-45	myoglobin	Homo sapiens	107-116
18652826-4	2008	We tested differentiation conditions including the use of low oxygen, ascorbic acid, and prolonged in vitro differentiation time which resulted in a 10-fold increase in the number of MAP2-positive neurons (up to 40-50% of total cells as compared to controls).	Oxygen	62-68	microtubule associated protein 2	Homo sapiens	183-187
17875644-3	2007	In aerobic cells, O(2)-dependent prolyl hydroxylation of HIF-1alpha is required for binding of the von Hippel-Lindau tumor suppressor protein VHL, which then recruits the Elongin C ubiquitin-ligase complex.	Oxygen	18-22	elongin C	Homo sapiens	171-180
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Oxygen	47-53	gamma-glutamyltransferase 1	Rattus norvegicus	98-101
17684156-7	2007	These data demonstrate that PHD-dependent oxygen-sensing recruits both the hypoxia-inducible factor (HIF) and ATF-4 systems, and hence not only confers adaptive responses but also cell fate decisions.	Oxygen	42-48	activating transcription factor 4	Homo sapiens	110-115
18056037-4	2007	Prolonged hypoxia (5% O2 for 5-6 days) also induced the expression of calcitonin receptor at high levels, and those of cathepsin K, and tartarate-resistant alkaline phosphatase (TRAP) at low-moderate levels in macrophage cells.	Oxygen	22-24	acid phosphatase 5, tartrate resistant	Mus musculus	136-176
18689483-4	2008	By using phosphoprotein affinity chromatography and immunoblot analyses, we showed that the phosphorylated PrrA levels in the cell increase with decreasing oxygen tensions.	Oxygen	156-162	global response regulator transcription factor PrrA	Rhodobacter sphaeroides 2.4.1	107-111
19337405-4	2008	The VEGF-mediated assembly of a functional vasculature is also a prerequisite for the proper formation of other organs and for tissue homeostasis, because blood vessels deliver oxygen and nutrients and vascular endothelium provides inductive signals to other tissues.	Oxygen	177-183	vascular endothelial growth factor A	Mus musculus	4-8
18056037-4	2007	Prolonged hypoxia (5% O2 for 5-6 days) also induced the expression of calcitonin receptor at high levels, and those of cathepsin K, and tartarate-resistant alkaline phosphatase (TRAP) at low-moderate levels in macrophage cells.	Oxygen	22-24	acid phosphatase 5, tartrate resistant	Mus musculus	178-182
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Oxygen	47-53	gamma-glutamyltransferase 1	Rattus norvegicus	137-140
8458778-12	1993	The isocapnic hyperpnea using 95% O2-5% CO2, but not 5% CO2 in air, caused bronchoconstriction that was significantly blocked by acute DMTU, acute SOD + CAT, and tachykinin depletion.	Oxygen	34-36	catalase	Cavia porcellus	153-156
17997700-5	2007	Interaction of Abeta with Abeta-binding alcohol dehydrogenase (ABAD), a short-chain alcohol dehydrogenase in the mitochondrial matrix, leads to mitochondrial dysfunction evidenced by increased reactive oxygen species generation, mitochondrial membrane permeability formation and caspase-3-like activity induction, and decreased activities of the Krebs cycle.	Oxygen	202-208	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	63-67
18797187-4	2008	The protein-deacetylase, SIRT1, has received much attention because of its roles in oxygen metabolism, cellular stress response, aging, and has been investigated in various species and cell types including embryonic stem cells.	Oxygen	84-90	sirtuin 1	Homo sapiens	25-30
18585389-3	2008	The N-terminal half folds into two light-oxygen-voltage-sensing domains called LOV1 and LOV2, each binding a flavin mononucleotide to absorb blue light.	Oxygen	41-47	NAC domain containing protein 35	Arabidopsis thaliana	79-83
18585389-10	2008	The topology in homodimeric associations of the LOV1 domains is discussed when referring to those of homodimers or heterodimers of light-oxygen-voltage-sensing or Per-ARNT-Sim domains.	Oxygen	137-143	NAC domain containing protein 35	Arabidopsis thaliana	48-52
18375516-0	2008	Oxygen pressurized X-ray crystallography: probing the dioxygen binding site in cofactorless urate oxidase and implications for its catalytic mechanism.	Oxygen	0-6	urate oxidase (pseudogene)	Homo sapiens	92-105
18375516-0	2008	Oxygen pressurized X-ray crystallography: probing the dioxygen binding site in cofactorless urate oxidase and implications for its catalytic mechanism.	Oxygen	54-62	urate oxidase (pseudogene)	Homo sapiens	92-105
18375516-3	2008	An application is given on urate oxidase (UOX), a cofactorless enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate in the presence of dioxygen.	Oxygen	152-160	urate oxidase (pseudogene)	Homo sapiens	27-40
18375516-3	2008	An application is given on urate oxidase (UOX), a cofactorless enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate in the presence of dioxygen.	Oxygen	152-160	urate oxidase (pseudogene)	Homo sapiens	42-45
18204143-0	2007	A common oxygen sensor regulates the sensory discharge and glomus cell HIF-1alpha in the rat carotid body.	Oxygen	9-15	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	71-81
18095590-0	2007	[The influence of oxygen and glucose deprivation on the expression of neurite growth inhibitor Nogo-A in oligodendrocyte precursor cell of rat].	Oxygen	18-24	reticulon 4	Rattus norvegicus	95-101
18375516-4	2008	UOX crystals in complex with a competitive inhibitor of its natural substrate are submitted to an increasing pressure of 1.0, 2.5, or 4.0 MPa of gaseous oxygen.	Oxygen	153-159	urate oxidase (pseudogene)	Homo sapiens	0-3
8441751-3	1993	The cytosine base of CTP interacts with the main chain carbonyl oxygens of rTyr-89 and rIle-12, the main chain NH of rIle-12, and the amino group of rLys-60.	Oxygen	64-71	solute carrier family 25 member 1	Homo sapiens	21-24
32688810-1	2008	Alternative oxidase (AOX) is a terminal quinol oxidase located in the respiratory electron transport chain that catalyses the oxidation of quinol and the reduction of oxygen to water.	Oxygen	167-173	acyl-CoA oxidase 1	Homo sapiens	0-19
17942912-2	2007	In this study, we show that LRP-1 is abundantly expressed in severe combined immunodeficient (SCID) mouse xenografts by various human cancer cell lines that express very low or undetectable levels of LRP-1 when cultured in 21% O2 in vitro (standard cell culture conditions).	Oxygen	227-229	low density lipoprotein receptor-related protein 1	Mus musculus	28-33
8441751-5	1993	The phosphate oxygens of CTP interact with the amino group of rLys-94, the hydroxyl of rThr-82, and an imidazole nitrogen of rHis-20.	Oxygen	14-21	solute carrier family 25 member 1	Homo sapiens	25-28
17556672-5	2007	Conversely, FDLE cultured at 21% O(2) expressed lower levels of 4E-BP and maintained eIF4E-eIF4G association independent of DEX.	Oxygen	33-37	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	91-96
32688810-1	2008	Alternative oxidase (AOX) is a terminal quinol oxidase located in the respiratory electron transport chain that catalyses the oxidation of quinol and the reduction of oxygen to water.	Oxygen	167-173	acyl-CoA oxidase 1	Homo sapiens	21-24
8421708-5	1993	In response to 4-h acute mild hypoxia, ODC activity in fetal rat brain (cerebrum, cerebellum, and hippocampus) increased to 330-450% from control values (P &lt; 0.001), after which it declined to control levels in 6-8 h. The 4-h ODC response varied inversely with inspired O2 concentration and was not mimicked by beta 2 agonist or blocked by beta 2-antagonist administration.	Oxygen	273-275	ornithine decarboxylase 1	Rattus norvegicus	39-42
18437097-9	2008	NAC-treated piglets had significantly higher carotid oxygen delivery and lower cerebral lactate levels than that of H-R controls with corresponding changes in carotid arterial flow and vascular resistance.	Oxygen	53-59	X-linked Kx blood group	Homo sapiens	0-3
17615278-1	2007	The reaction of nitrite with deoxyhemoglobin results in the production of nitric oxide and methemoglobin, a reaction recently proposed as an important oxygen-sensitive source of vasoactive nitric oxide during hypoxic and anoxic stress, with several animal studies suggesting that nitrite may have therapeutic potential.	Oxygen	151-157	hemoglobin subunit gamma 2	Homo sapiens	91-104
8418859-1	1993	An electron density map of the reactive, Cd2+ form of crystalline phosphoglucomutase from X-ray diffraction studies shows that the enzymic phosphate donates a nonbridging oxygen to the ligand sphere of the bound metal ion, which appears to be tetracoordinate.	Oxygen	171-177	CD2 molecule	Homo sapiens	41-44
17879999-10	2007	These proteins have been reported with their important roles in microparticles in human blood cells: vWF is a platelet and endothelial cell product that binds to P-selectin, GP1b, and GP IIb/IIIa, and beta-globin is one of the peptides of hemoglobin involved in the transportation of oxygen by red blood cells.	Oxygen	284-290	integrin subunit alpha 2b	Homo sapiens	184-190
8135658-10	1993	When Hepes buffer with a low oxygen content was used in cell isolation, pure cultures showed significantly lower GR and GPx activities than those first mentioned.	Oxygen	29-35	glutathione-disulfide reductase	Rattus norvegicus	113-115
17927916-5	2007	Recovery of O2 induced phosphorylation and diminution of chromatin bound MCM2, whereas cytosolic MCM2 increased.	Oxygen	12-14	minichromosome maintenance complex component 2	Homo sapiens	73-77
8396470-4	1993	The ability of ascitic PMNs to produce active oxygen (superoxide, H2O2, myeloperoxidase) was significantly more than that of blood PMNs in each group at 20 h after peritonitis induction.	Oxygen	46-52	myeloperoxidase	Rattus norvegicus	66-87
17697942-5	2007	Accompanying the upregulation of Nox2, there was a 2.28+/-0.18-fold increase in O2.- production, a dramatic induction of p21cip1 and p53, cell cycle arrest, and the onset of apoptosis (all p&lt;0.05).	Oxygen	80-82	cytochrome b-245 beta chain	Homo sapiens	33-37
1336457-0	1992	Hydration of the Gly2 and Gly3 peptide oxygens of [Leu5]-enkephalin in aqueous solution as revealed by the combined use of 17O-NMR and Fourier-transform infrared spectroscopy.	Oxygen	39-46	tripartite motif containing 13	Homo sapiens	51-55
16920221-6	2007	In contrast, after 60 min of incubation, SOD decreased and this facilitated an increase in O2(*-) production.	Oxygen	91-93	SOD	Triticum aestivum	41-44
17545941-5	2007	Exposure of primary mouse hepatocytes in culture to 1% oxygen led to increased production of ROS and phosphorylation of JNK.	Oxygen	55-61	mitogen-activated protein kinase 8	Mus musculus	120-123
1445857-13	1992	In contrast, the doubly-ligated species exhibited two distinct patterns of oxygen equilibria: the asymmetric species (alpha +CN beta +CN)(alpha beta) showed very high cooperativity (nmax = 1.94) and low affinity (pmedian = 6.0 Torr), while the other three doubly-ligated species showed diminished cooperativity (nmax = 1.23) and considerably higher oxygen affinity (pmedian = 0.4 Torr).	Oxygen	75-81	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	125-132
1445857-13	1992	In contrast, the doubly-ligated species exhibited two distinct patterns of oxygen equilibria: the asymmetric species (alpha +CN beta +CN)(alpha beta) showed very high cooperativity (nmax = 1.94) and low affinity (pmedian = 6.0 Torr), while the other three doubly-ligated species showed diminished cooperativity (nmax = 1.23) and considerably higher oxygen affinity (pmedian = 0.4 Torr).	Oxygen	349-355	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	125-132
17532579-0	2007	Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.	Oxygen	10-16	neuroglobin	Homo sapiens	94-105
17532579-1	2007	Several studies support the hypothesis that neuroglobin and cytoglobin play a protective role against cell death when cellular oxygen supply is critical.	Oxygen	127-133	neuroglobin	Homo sapiens	44-55
17475674-0	2007	Rat carotid body chemosensory discharge and glomus cell HIF-1 alpha expression in vitro: regulation by a common oxygen sensor.	Oxygen	112-118	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	56-67
1445857-14	1992	Extremely high oxygen affinities were found for the triply-ligated species (alpha +CN beta +CN)(alpha beta +CN) and (alpha +CN beta +CN)(alpha +CN beta) (pmedian = 0.2 Torr).	Oxygen	15-21	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	83-90
1443180-1	1992	To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection.	Oxygen	43-45	erythropoietin	Rattus norvegicus	67-81
17629795-7	2007	In contrast, STAT1 activation occurred as early as after 48 h of oxygen exposure, which did not differ between the two strains.	Oxygen	65-71	signal transducer and activator of transcription 1	Mus musculus	13-18
1443180-1	1992	To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection.	Oxygen	43-45	erythropoietin	Rattus norvegicus	83-86
17329595-1	2007	Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated with small increases in the expression of glucose transporter 1 (SLC2A1), anaphase promoting complex (ANAPC1), and myotrophin (MTPN), suggesting a role for oxygen in the regulation of embryo development, mediated through oxygen-sensitive gene expression.	Oxygen	9-15	anaphase promoting complex subunit 1	Bos taurus	223-229
17329595-2	2007	However, bovine embryos, to at least the blastocyst stage, lack detectable levels of the key regulator of oxygen-sensitive gene expression, hypoxia-inducible 1 alpha (HIF1A), while the less well-characterized HIF2 alpha protein is readily detectable.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha	Bos taurus	167-172
1450954-0	1992	Neuroprotective effect of protein kinase C inhibitors on oxygen/glucose free-induced decreases in 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices.	Oxygen	57-63	carbonic anhydrase 1	Rattus norvegicus	124-127
1450954-2	1992	We have demonstrated that rat hippocampal slices exposed to oxygen/glucose-free medium showed decreases in 2-deoxyglucose (2-DG) uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals.	Oxygen	60-66	carbonic anhydrase 1	Rattus norvegicus	140-143
17600430-3	2007	Strong attractive forces between oxygen and aluminum atoms break N-O and N-N bonds in the RDX and, subsequently, the dissociated oxygen atoms and NO molecules oxidize the Al surface.	Oxygen	33-39	radixin	Homo sapiens	90-93
17600430-3	2007	Strong attractive forces between oxygen and aluminum atoms break N-O and N-N bonds in the RDX and, subsequently, the dissociated oxygen atoms and NO molecules oxidize the Al surface.	Oxygen	129-135	radixin	Homo sapiens	90-93
1450954-3	1992	Therefore we examined the effect of protein kinase C inhibitors on oxygen/glucose free-induced impairments of 2-DG uptake and CA1 field potentials.	Oxygen	67-73	carbonic anhydrase 1	Rattus norvegicus	126-129
1450954-6	1992	Therefore we examined the effect of pretreatment with phorbol ester for 90 min on oxygen/glucose free-induced decreases in 2-DG uptake and CA1 field potentials.	Oxygen	82-88	carbonic anhydrase 1	Rattus norvegicus	139-142
1325990-3	1992	Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as the time in reoxygenation (maximal IL-1 release at 6-9 h).	Oxygen	41-47	interleukin 1 alpha	Homo sapiens	15-19
17321126-6	2007	A linear decrease of the reduction current of oxygen at the {GOx/CNT}-modified electrodes with the addition of glucose suggests that such multilayer films of GOx retain the bioactivity and can be used as reagentless glucose biosensors.	Oxygen	46-52	hydroxyacid oxidase 1	Homo sapiens	61-64
17321126-6	2007	A linear decrease of the reduction current of oxygen at the {GOx/CNT}-modified electrodes with the addition of glucose suggests that such multilayer films of GOx retain the bioactivity and can be used as reagentless glucose biosensors.	Oxygen	46-52	hydroxyacid oxidase 1	Homo sapiens	158-161
1504091-0	1992	Effect of NaCl addition on nanosecond O2 escaping reaction of myoglobin: evidences for the transition of myoglobin dynamic structure at 20 degrees C. We studied the nanosecond (ns) geminate O2 escape reaction from the protein interior of myoglobin (Mb) to the solvent phase in the temperature range of 5-40 degrees C containing 0-0.1 M NaCl.	Oxygen	38-40	myoglobin	Homo sapiens	62-71
17427919-14	2007	Loss of myelin basic protein labeling was seen in P11 pups after oxygen exposure, and E2 attenuated this injury.	Oxygen	65-71	myelin basic protein	Rattus norvegicus	8-28
1504091-0	1992	Effect of NaCl addition on nanosecond O2 escaping reaction of myoglobin: evidences for the transition of myoglobin dynamic structure at 20 degrees C. We studied the nanosecond (ns) geminate O2 escape reaction from the protein interior of myoglobin (Mb) to the solvent phase in the temperature range of 5-40 degrees C containing 0-0.1 M NaCl.	Oxygen	190-192	myoglobin	Homo sapiens	62-71
1617671-0	1992	Mechanism of c-fos induction by active oxygen.	Oxygen	39-45	FBJ osteosarcoma oncogene	Mus musculus	13-18
17479408-8	2007	In addition, elevated intracellular levels of ROS components (O2-* and H2O2) and activation of JNK, ERK, and MAPK were found with corresponding upregulation of JWA protein expression.	Oxygen	62-64	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	160-163
1617671-1	1992	We have compared the mechanisms of the transcriptional induction of c-fos in mouse epidermal cells JB6 (clone 30) by an extracellular burst of active oxygen of the type produced by inflammatory phagocytes to induction by serum and phorbol ester.	Oxygen	150-156	FBJ osteosarcoma oncogene	Mus musculus	68-73
17284534-4	2007	In vitro analysis showed that BMP4 and SCF are necessary for the expansion of stress BFU-E, but only when spleen cells were cultured in BMP4 + SCF at low-oxygen concentrations did we recapitulate the expansion of stress BFU-E observed in vivo.	Oxygen	154-160	KIT ligand	Homo sapiens	39-42
1617671-3	1992	Experiments with stable transfectants containing fos 5" upstream regulatory sequences linked to an HSV-tk-chloram-phenicol-acetyl-transferase reporter construct indicate that the joint dyad symmetry element-AP-1 motifs exert the most potent enhancer effect in response to active oxygen as well as serum.	Oxygen	279-285	FBJ osteosarcoma oncogene	Mus musculus	49-52
17284667-4	2007	In this screen, we identified Drosophila CG14709 gene as a homolog of the human multidrug resistance protein 4 (MRP4/ABCC4) that is tightly regulated to oxygen.	Oxygen	153-159	ATP binding cassette subfamily C member 4	Homo sapiens	112-116
1617671-5	1992	In contrast to these common features only active oxygen induction of c-fos required the poly-ADP-ribosylation of chromosomal proteins.	Oxygen	49-55	FBJ osteosarcoma oncogene	Mus musculus	69-74
17284667-4	2007	In this screen, we identified Drosophila CG14709 gene as a homolog of the human multidrug resistance protein 4 (MRP4/ABCC4) that is tightly regulated to oxygen.	Oxygen	153-159	ATP binding cassette subfamily C member 4	Homo sapiens	117-122
17452787-3	2007	Previously, FGE was crystallized in complex with a chloride ion which, based on its similar polarizability and hydrophobicity, indicates the site of molecular oxygen binding.	Oxygen	159-165	sulfatase modifying factor 1	Homo sapiens	12-15
1617671-6	1992	The inhibitors of ADP-ribose transferase benzamide and 3-amino-benzamide suppressed the elongation of the c-fos message and the de novo synthesis of nuclear factors, among them c-Fos and c-Jun, which bind to the fos-AP-1 motif in vitro only following stimulation with active oxygen.	Oxygen	275-281	FBJ osteosarcoma oncogene	Mus musculus	106-111
17494952-7	2007	In untreated animals exposed to 3 days of CH, expression of proliferating cell nuclear antigen (PCNA), a marker of mitosis, was increased in lobules of oxygen-sensitive type I cells and in extralobular vascular and connective tissue cells.	Oxygen	152-158	proliferating cell nuclear antigen	Rattus norvegicus	60-94
1617671-6	1992	The inhibitors of ADP-ribose transferase benzamide and 3-amino-benzamide suppressed the elongation of the c-fos message and the de novo synthesis of nuclear factors, among them c-Fos and c-Jun, which bind to the fos-AP-1 motif in vitro only following stimulation with active oxygen.	Oxygen	275-281	FBJ osteosarcoma oncogene	Mus musculus	177-182
17494952-7	2007	In untreated animals exposed to 3 days of CH, expression of proliferating cell nuclear antigen (PCNA), a marker of mitosis, was increased in lobules of oxygen-sensitive type I cells and in extralobular vascular and connective tissue cells.	Oxygen	152-158	proliferating cell nuclear antigen	Rattus norvegicus	96-100
1617671-6	1992	The inhibitors of ADP-ribose transferase benzamide and 3-amino-benzamide suppressed the elongation of the c-fos message and the de novo synthesis of nuclear factors, among them c-Fos and c-Jun, which bind to the fos-AP-1 motif in vitro only following stimulation with active oxygen.	Oxygen	275-281	FBJ osteosarcoma oncogene	Mus musculus	108-111
1617671-11	1992	We observed that Fos protein is weakly poly-ADP-ribosylated in response to active oxygen, but the functional role of this modification remains unclear.	Oxygen	82-88	FBJ osteosarcoma oncogene	Mus musculus	17-20
17355156-2	2007	Exposure to a 25 W remote oxygen-containing plasma was found to convert the surface of POSS-MA films from hydrophobic to hydrophilic within 20 s. The exposure time needed for this conversion to occur decreased as the O2/N2 ratio in the plasma environment increased, indicating a positive correlation between the hydrophilicity and the presence of oxygen in the plasma.	Oxygen	26-32	immunoglobulin kappa variable 1D-39	Homo sapiens	217-222
1320874-5	1992	On the basis of these results and several earlier reports in which various P450 depressants have been shown to depress superoxide production from microsomes and to prolong the lives of rodents in hyperoxia, we conclude that oxygen tolerance induced by interleukin-1 administration is likewise mediated, at least in part, by reduced generation of superoxide anion from cytochrome P450 monooxygenase system.	Oxygen	224-230	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	368-397
17355156-2	2007	Exposure to a 25 W remote oxygen-containing plasma was found to convert the surface of POSS-MA films from hydrophobic to hydrophilic within 20 s. The exposure time needed for this conversion to occur decreased as the O2/N2 ratio in the plasma environment increased, indicating a positive correlation between the hydrophilicity and the presence of oxygen in the plasma.	Oxygen	347-353	immunoglobulin kappa variable 1D-39	Homo sapiens	217-222
17300770-13	2007	In addition, the decrease of mRNA and protein levels in IGF-I/IGF-IR of VSD patients show related to the saturation of oxygen in the right atrium and the ratio of systolic right ventricular pressure to left ventricular pressure.	Oxygen	119-125	insulin like growth factor 1 receptor	Homo sapiens	62-68
1318335-3	1992	For example, interaction of C1q with its cell-surface receptor on neutrophils induces the activation of the respiratory burst, a finding previously documented using a chemiluminescent assay to detect oxygen radical formation.	Oxygen	200-206	complement C1q A chain	Homo sapiens	28-31
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	39-41	complement C1q A chain	Homo sapiens	0-3
17120306-9	2007	Interestingly, the abundance of transcript for IFN-tau in IVP embryos produced under 5% O2 concentration was similar to in vivo counterparts.	Oxygen	88-90	interferon-tau-like	Bos taurus	47-54
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	39-41	complement C1q A chain	Homo sapiens	297-300
18851627-0	2008	Fingerprints for spin-selection rules in the interaction dynamics of O2 at Al(111).	Oxygen	69-71	spindlin 1	Homo sapiens	17-21
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	complement C1q A chain	Homo sapiens	0-3
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	complement C1q A chain	Homo sapiens	297-300
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	complement C1q A chain	Homo sapiens	0-3
17411120-1	2007	Five-dimensional nonadiabatic quantum dynamics studies have been carried out on two new potential energy surfaces of S(2)((1)A(")) and T(7)((3)A(")) states for the title oxygen molecules collision with coplanar configurations, along with the spin-orbit coupling between them.	Oxygen	170-176	spindlin 1	Homo sapiens	242-246
18438937-8	2008	The level of 55-kDa RAGE in autopsy brain of patients undergoing neurodegeneration with accompanying inflammation [multiple sclerosis and neuronal ceroid-lipofuscinosis (Batten"s disease)] was much lower than that in age-matched controls, suggesting that shedding of RAGE might occur as reactive oxygen species accumulate in brain cells and be part of the process of neurodegeneration.	Oxygen	296-302	advanced glycosylation end-product specific receptor	Homo sapiens	20-24
18397542-7	2008	GLUT1 gene expression, protein level and glucose transport by human adipocytes are markedly increased by hypoxia, indicating that low O2 tension stimulates glucose utilisation.	Oxygen	134-136	solute carrier family 2 member 1	Homo sapiens	0-5
16920014-7	2007	OLE1 is regulated through Spt23p and Mga2p by multiple systems that control its transcription and mRNA stability in response to diverse stimuli that include nutrient fatty acids, carbon source, metal ions and the availability of oxygen.	Oxygen	229-235	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
1318335-5	1992	C1q coated to microtiter wells induced O2- release, which occurred microtiter wells induced O2- release, which occurred after a lag period of 10 to 20 min, and was then sustained over approximately 1 h. O2- production could be triggered by the purified pepsin-resistant, collagen-like fragment of C1q, but not by mannose-binding protein and pulmonary surfactant protein A, proteins that also contain collagen-like domains.	Oxygen	92-94	complement C1q A chain	Homo sapiens	297-300
17278977-10	2007	CONCLUSION: These results show that the release of O2*- during auto-oxidation of conjugated oxyhaemoglobin is associated with the observed increase in MAP, which may be a result of the vasoconstriction caused by an increase in activation of ETR-B.	Oxygen	51-53	LOW QUALITY PROTEIN: endothelin receptor type B	Cavia porcellus	241-246
1318335-6	1992	Concentrations of C1q which promoted a vigorous O2- generation did not induce release of neutrophil primary granules and caused little or no secondary granule release.	Oxygen	48-50	complement C1q A chain	Homo sapiens	18-21
1318335-7	1992	Investigation of the biochemical events mediating C1q stimulated O2- production by neutrophils revealed that the response invoked two biochemical pathways with distinct sensitivities to previously described inhibitors.	Oxygen	65-67	complement C1q A chain	Homo sapiens	50-53
16998843-2	2007	However, bovine embryos to at least the blastocyst stage lack a key regulator of oxygen-sensitive gene expression, hypoxia-inducible factor 1alpha (HIF1alpha).	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Bos taurus	115-146
16998843-2	2007	However, bovine embryos to at least the blastocyst stage lack a key regulator of oxygen-sensitive gene expression, hypoxia-inducible factor 1alpha (HIF1alpha).	Oxygen	81-87	hypoxia inducible factor 1 subunit alpha	Bos taurus	148-157
18456002-3	2008	The enzyme methionine sulfoxide reductase A (MsrA) plays a critical role in the antioxidant response by repairing methionine-oxidized proteins and by participating in cycles of methionine oxidation and reduction that have the net effect of consuming reactive oxygen species.	Oxygen	259-265	methionine sulfoxide reductase A	Homo sapiens	11-43
18456002-3	2008	The enzyme methionine sulfoxide reductase A (MsrA) plays a critical role in the antioxidant response by repairing methionine-oxidized proteins and by participating in cycles of methionine oxidation and reduction that have the net effect of consuming reactive oxygen species.	Oxygen	259-265	methionine sulfoxide reductase A	Homo sapiens	45-49
1318335-10	1992	Neither phase of C1q-mediated O2- production was inhibited by pertussis toxin, a strong inhibitor of the G-protein-coupled FMLP-mediated response.	Oxygen	30-32	complement C1q A chain	Homo sapiens	17-20
18456002-5	2008	By comparing the effects of MsrA and the small-molecule antioxidants N-acetylcysteine and vitamin E, we provide evidence that MsrA protects against PD-related stresses primarily via methionine sulfoxide repair rather than by scavenging reactive oxygen species.	Oxygen	245-251	methionine sulfoxide reductase A	Homo sapiens	126-130
1318335-11	1992	In summary, C1q-triggered O2- production is relatively unique both in terms of the kinetics of the response and the biochemical pathways evoked.	Oxygen	26-28	complement C1q A chain	Homo sapiens	12-15
1620103-2	1992	The factor is encoded by two genes in Saccharomyces cerevisiae, called TIF51A and TIF51B, which are regulated reciprocally by oxygen and by heme.	Oxygen	126-132	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	71-77
19115638-0	2008	[Expression of vascular endothelial growth factor and pigment epithelium derived factor in mouse oxygen-induced retinopathy and its significance].	Oxygen	97-103	vascular endothelial growth factor A	Mus musculus	15-49
19115638-1	2008	OBJECTIVE: To investigate the expression and significance of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in oxygen-induced mouse retinopathy.	Oxygen	151-157	vascular endothelial growth factor A	Mus musculus	61-95
19115638-1	2008	OBJECTIVE: To investigate the expression and significance of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in oxygen-induced mouse retinopathy.	Oxygen	151-157	vascular endothelial growth factor A	Mus musculus	97-101
17071723-4	2007	Growth and respiratory compliance were significantly impaired in pups exposed to 85% O(2), and these pups also exhibited a pronounced arrest of alveolarization, accompanied by dysregulated expression and localization of both receptor (ALK-1, ALK-3, ALK-6, and the TGF-beta type II receptor) and Smad (Smads 1, 3, and 4) proteins.	Oxygen	85-89	bone morphogenetic protein receptor, type 1A	Mus musculus	242-247
17038488-6	2007	VEGF secretion rate is determined from the predicted tissue oxygen level through its effect on the hypoxia inducible factor-1alpha transcription factor.	Oxygen	60-66	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	99-130
17045424-2	2007	HIF-1alpha is the oxygen-regulated subunit of HIF-1, which regulates the transcription of genes involved in oxygen homeostasis in response to hypoxia.	Oxygen	18-24	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
17045424-2	2007	HIF-1alpha is the oxygen-regulated subunit of HIF-1, which regulates the transcription of genes involved in oxygen homeostasis in response to hypoxia.	Oxygen	108-114	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
1525853-4	1992	The specific activities of enzymes involved in oxygen detoxification, such as superoxide dismutase, glucose 6-phosphate dehydrogenase and glutathione reductase, were decreased in par1 mutants and increased after PAR1 over-expression.	Oxygen	47-53	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	100-133
19071317-4	2007	In the presence of oxygen, GOx converts glucose to gluconic acid and hydrogen peroxide (H(2)O(2)).	Oxygen	19-25	hydroxyacid oxidase 1	Homo sapiens	27-30
18607090-3	2008	Both isoforms comprise a tandem pair of blue-light-absorbing light-oxygen-voltage domains named LOV1 and LOV2 in the N-terminal half and a serine/threonine kinase domain in the C-terminal half.	Oxygen	67-73	NAC domain containing protein 35	Arabidopsis thaliana	96-100
18342288-0	2008	Effects of oxytocin-induced uterine hyperstimulation during labor on fetal oxygen status and fetal heart rate patterns.	Oxygen	75-81	oxytocin/neurophysin I prepropeptide	Homo sapiens	11-19
1735227-4	1992	Cell proliferation, hydroxyproline production, and alkaline phosphatase synthesis were greatest in 3% oxygen, whereas osteocalcin production was least in 3% oxygen.	Oxygen	157-163	bone gamma-carboxyglutamate protein	Bos taurus	118-129
18342288-1	2008	OBJECTIVE: The objective of the study was to evaluate effects of oxytocin-induced hyperstimulation on fetal oxygen saturation and fetal heart rate patterns.	Oxygen	108-114	oxytocin/neurophysin I prepropeptide	Homo sapiens	65-73
18269197-2	2007	Myoglobin is a well-characterized protein and numerous studies have established that it has an essential role in facilitated oxygen transport in striated muscles.	Oxygen	125-131	myoglobin	Mus musculus	0-9
18269197-5	2007	Characterization of the viable myoglobin null mice has uncovered a number of molecular and cellular adaptive mechanisms that function to promote oxygen delivery in the mutant striated muscle cell.	Oxygen	145-151	myoglobin	Mus musculus	31-40
18269197-6	2007	Moreover, cellular and physiological studies, using the myoglobin deficient mouse model, support the conclusion that the functions of myoglobin include: facilitated oxygen transport, the storage of oxygen and a scavenger of nitric oxide or reactive oxygen species.	Oxygen	165-171	myoglobin	Mus musculus	56-65
18269197-6	2007	Moreover, cellular and physiological studies, using the myoglobin deficient mouse model, support the conclusion that the functions of myoglobin include: facilitated oxygen transport, the storage of oxygen and a scavenger of nitric oxide or reactive oxygen species.	Oxygen	165-171	myoglobin	Mus musculus	134-143
18269197-6	2007	Moreover, cellular and physiological studies, using the myoglobin deficient mouse model, support the conclusion that the functions of myoglobin include: facilitated oxygen transport, the storage of oxygen and a scavenger of nitric oxide or reactive oxygen species.	Oxygen	198-204	myoglobin	Mus musculus	56-65
18269197-6	2007	Moreover, cellular and physiological studies, using the myoglobin deficient mouse model, support the conclusion that the functions of myoglobin include: facilitated oxygen transport, the storage of oxygen and a scavenger of nitric oxide or reactive oxygen species.	Oxygen	198-204	myoglobin	Mus musculus	134-143
17404017-1	2007	Hypoxic cancer cells overexpress Glucose transporter 1 (GLUT-1) to accelerate glucose intake mainly for low effective, anaerobic respiration, so that they would not die of oxygen deficiency.	Oxygen	172-178	solute carrier family 2 member 1	Homo sapiens	33-54
18560760-0	2008	TGFbeta-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions.	Oxygen	107-113	transforming growth factor beta induced	Homo sapiens	0-23
18373623-7	2008	Physiologically, these observations suggest that as contributions of AOX to combined oxygen reduction increase, E(0)(REF) decreases because of different temperature sensitivities for V(max), and delta increases because of different temperature sensitivities for K(1/2) of AOX and COX.	Oxygen	85-91	acyl-CoA oxidase 1	Homo sapiens	69-72
18574584-1	2008	NADPH oxidase of the phagocytic cells (Nox2) transfers electrons from cytosolic NADPH to molecular oxygen in the extracellular or intraphagosomal space.	Oxygen	99-105	cytochrome b-245 beta chain	Homo sapiens	39-43
17404017-1	2007	Hypoxic cancer cells overexpress Glucose transporter 1 (GLUT-1) to accelerate glucose intake mainly for low effective, anaerobic respiration, so that they would not die of oxygen deficiency.	Oxygen	172-178	solute carrier family 2 member 1	Homo sapiens	56-62
1288088-6	1992	We suggest that the differences in oxygen uptake and release kinetics might contribute to explain the previously found accumulation of oxygen in BAL.	Oxygen	35-41	poly(ADP-ribose) polymerase family member 9	Homo sapiens	145-148
17237644-2	2007	In smooth muscle cells, H2O2 induces production of O2 by activating NADPH oxidase.	Oxygen	26-28	2,4-dienoyl-CoA reductase 1	Homo sapiens	68-73
18524954-11	2008	The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1, besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes avoidance of high CO2.	Oxygen	125-127	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	4-9
18524954-11	2008	The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1, besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes avoidance of high CO2.	Oxygen	125-127	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	73-78
17237644-4	2007	Recent studies have documented increased O2 in endothelial cells exposed to H2O2 via uncoupled nitric oxide synthase (NOS) and NADPH oxidase under static conditions.	Oxygen	41-43	2,4-dienoyl-CoA reductase 1	Homo sapiens	127-132
1288088-6	1992	We suggest that the differences in oxygen uptake and release kinetics might contribute to explain the previously found accumulation of oxygen in BAL.	Oxygen	135-141	poly(ADP-ribose) polymerase family member 9	Homo sapiens	145-148
17237644-9	2007	In addition, we demonstrate that l-NAME, an inhibitor of NOS, and apocynin, an inhibitor of NADPH oxidase, reduced O2 levels in PAEC treated with H2O2 under physiologic shear suggesting that both NOS and NADPH oxidase contribute to H2O2-induced O2 in PAEC.	Oxygen	115-117	2,4-dienoyl-CoA reductase 1	Homo sapiens	92-97
17237644-9	2007	In addition, we demonstrate that l-NAME, an inhibitor of NOS, and apocynin, an inhibitor of NADPH oxidase, reduced O2 levels in PAEC treated with H2O2 under physiologic shear suggesting that both NOS and NADPH oxidase contribute to H2O2-induced O2 in PAEC.	Oxygen	115-117	2,4-dienoyl-CoA reductase 1	Homo sapiens	204-209
1288088-7	1992	The positive difference between the release and uptake kinetics at the beginning of the curves is consistent with a steady oxygen penetration through the BAL.	Oxygen	123-129	poly(ADP-ribose) polymerase family member 9	Homo sapiens	154-157
17237644-9	2007	In addition, we demonstrate that l-NAME, an inhibitor of NOS, and apocynin, an inhibitor of NADPH oxidase, reduced O2 levels in PAEC treated with H2O2 under physiologic shear suggesting that both NOS and NADPH oxidase contribute to H2O2-induced O2 in PAEC.	Oxygen	148-150	2,4-dienoyl-CoA reductase 1	Homo sapiens	92-97
17237644-9	2007	In addition, we demonstrate that l-NAME, an inhibitor of NOS, and apocynin, an inhibitor of NADPH oxidase, reduced O2 levels in PAEC treated with H2O2 under physiologic shear suggesting that both NOS and NADPH oxidase contribute to H2O2-induced O2 in PAEC.	Oxygen	148-150	2,4-dienoyl-CoA reductase 1	Homo sapiens	204-209
18353899-0	2008	Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.	Oxygen	54-56	endothelial PAS domain protein 1	Rattus norvegicus	13-23
18353899-0	2008	Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.	Oxygen	75-77	endothelial PAS domain protein 1	Rattus norvegicus	13-23
18353899-3	2008	To address this, we monitored HIF-2alpha expression and oxygen consumption in an O2-sensitive immortalized rat adrenomedullary chromaffin (MAH) cell line.	Oxygen	81-83	endothelial PAS domain protein 1	Rattus norvegicus	30-40
17237644-10	2007	Co-inhibition of NOS and NADPH oxidase also reduced intracellular O2 levels under shear.	Oxygen	66-68	2,4-dienoyl-CoA reductase 1	Homo sapiens	25-30
1310005-1	1992	The root nodules of leguminous plants contain an oxygen-carrying protein which is somewhat similar to myoglobin.	Oxygen	49-55	myoglobin	Homo sapiens	102-111
17237644-11	2007	We conclude that H2O2-induced oxidative stress in endothelial cells exhibits increased intracellular O2 levels through NOS and NADPH oxidase under shear.	Oxygen	19-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	127-132
17365011-0	2007	High oxygen affinity hemoglobin variant in a Canadian family: Hb Bunbury [beta94(FG1)Asp--&gt;Asn, GAC--&gt;AAC].	Oxygen	5-11	glycine-N-acyltransferase	Homo sapiens	108-111
18353899-4	2008	Hypoxia (2-8% O2) caused a concentration- and time-dependent increase in HIF-2alpha induction, which was blocked in MAH cells with either RNA interference knockdown of the Rieske Fe-S protein, a component of complex III, or knockdown of cytochrome-c oxidase subunit of complex IV, or defective mitochondrial DNA (rho0 cells).	Oxygen	14-16	endothelial PAS domain protein 1	Rattus norvegicus	73-83
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	88-90	endothelial PAS domain protein 1	Rattus norvegicus	154-164
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	149-151	endothelial PAS domain protein 1	Rattus norvegicus	154-164
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	149-151	endothelial PAS domain protein 1	Rattus norvegicus	154-164
18353899-8	2008	These data suggest that in this O2-sensitive cell line, mitochondrial O2 consumption, rather than changes in ROS, regulates HIF-2alpha during hypoxia.	Oxygen	32-34	endothelial PAS domain protein 1	Rattus norvegicus	124-134
18353899-8	2008	These data suggest that in this O2-sensitive cell line, mitochondrial O2 consumption, rather than changes in ROS, regulates HIF-2alpha during hypoxia.	Oxygen	70-72	endothelial PAS domain protein 1	Rattus norvegicus	124-134
18441204-8	2008	The HNP-induced COX-2 and ET-1 production was attenuated by the treatment with the oxygen free radical scavenger N-acetyl-L-cysteine and the inhibitors of p38 MAPK and NF-kappaB, respectively.	Oxygen	83-89	kallikrein related peptidase 8	Homo sapiens	4-7
18248610-5	2008	Tyrosinase induction caused formation of reactive oxygen species in the cytosol and mitochondria, and neurotoxicity via activation of apoptotic stress-activated protein kinases and caspase 3.	Oxygen	50-56	tyrosinase	Homo sapiens	0-10
17180746-2	2007	The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth"s atmosphere or possibly in more localized environments.	Oxygen	218-224	methionine sulfoxide reductase A	Homo sapiens	134-138
17180746-2	2007	The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth"s atmosphere or possibly in more localized environments.	Oxygen	218-224	methionine sulfoxide reductase B2	Homo sapiens	143-147
18949084-6	2007	Intriguingly, the Ang IV-binding and AT(4) immunoreactivity were more intense in the carotid body of chronically hypoxic (CH) rats (breathing 10% oxygen for 4 weeks) than the normoxic (Nx) control.	Oxygen	146-152	angiogenin	Rattus norvegicus	18-21
17165921-0	2006	Spin-polarized peroxyl radical adducts formed from the addition of oxygen to amino acid radicals.	Oxygen	67-73	spindlin 1	Homo sapiens	0-4
1728718-2	1992	In vitro immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a, but albumin identically treated did not.	Oxygen	47-53	complement C4A (Rodgers blood group)	Homo sapiens	72-75
18243616-1	2008	Glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) have been established as being responsible for cellular adaptation to oxygen deficiency in tissue ischemia and hypoxia mediated by hypoxia-inducible factor 1.	Oxygen	146-152	solute carrier family 2 member 1	Homo sapiens	0-21
18243616-1	2008	Glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) have been established as being responsible for cellular adaptation to oxygen deficiency in tissue ischemia and hypoxia mediated by hypoxia-inducible factor 1.	Oxygen	146-152	solute carrier family 2 member 1	Homo sapiens	23-28
18181212-6	2008	In situ magnetic resonance imaging of VEGF gene inactivated mouse lungs revealed uneven inflation, residual trapped gas volumes upon oxygen absorption deflation/re-inflation, and loss of parenchymal structure; effects that were largely prevented by Dox.	Oxygen	133-139	vascular endothelial growth factor A	Mus musculus	38-42
17011183-3	2006	Recent advances in the structural biology of O(2)-activating copper enzymes range from the identification of novel copper centers, such as that of particulate methane monooxygenase, to the elucidation of the details of O(2) binding and reactivity in peptidylglycine alpha-hydroxylating monooxygenase.	Oxygen	45-49	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	250-299
10148023-2	1992	The maximum oxygen transfer of the SMO 2 (504 ml 0 2/min) was 57% higher than that for the SMO.	Oxygen	12-18	smoothened, frizzled class receptor	Homo sapiens	35-38
17019721-1	2006	Copper-oxygen complexes supported by beta-diketiminate and anilido-imine ligands have recently been reported (Aboelella et al., J Am Chem Soc 2004, 126, 16896; Reynolds et al., Inorg Chem 2005, 44, 6989) as potential biomimetic models for dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM).	Oxygen	7-13	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	280-329
17019721-1	2006	Copper-oxygen complexes supported by beta-diketiminate and anilido-imine ligands have recently been reported (Aboelella et al., J Am Chem Soc 2004, 126, 16896; Reynolds et al., Inorg Chem 2005, 44, 6989) as potential biomimetic models for dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM).	Oxygen	7-13	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	331-334
18356541-1	2008	Hypoxia inducible factor (HIF)-1alpha, a transcription factor, is abundantly expressed in the renal medulla and regulates many oxygen-sensitive genes such as nitric oxide synthase, cyclooxygenase-2, and heme oxygenase-1.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-37
18356541-1	2008	Hypoxia inducible factor (HIF)-1alpha, a transcription factor, is abundantly expressed in the renal medulla and regulates many oxygen-sensitive genes such as nitric oxide synthase, cyclooxygenase-2, and heme oxygenase-1.	Oxygen	127-133	heme oxygenase 1	Rattus norvegicus	203-219
10148023-2	1992	The maximum oxygen transfer of the SMO 2 (504 ml 0 2/min) was 57% higher than that for the SMO.	Oxygen	12-18	smoothened, frizzled class receptor	Homo sapiens	91-94
1750523-1	1991	We have used RNase protection to measure oxygen-dependent changes in erythropoietin (EPO) mRNA in isolated perfused kidneys and to compare the effect of hypoxia with the response to inhibitors of oxidative phosphorylation.	Oxygen	41-47	erythropoietin	Rattus norvegicus	69-83
18393501-6	2008	MD and DFT calculations also indicate either an octahedral or trigonal-bipyramidal complex between Zn(2+) and OT is lowest in energy with carbonyl oxygens being the primary ligation sites.	Oxygen	147-154	oxytocin/neurophysin I prepropeptide	Homo sapiens	110-112
1750523-1	1991	We have used RNase protection to measure oxygen-dependent changes in erythropoietin (EPO) mRNA in isolated perfused kidneys and to compare the effect of hypoxia with the response to inhibitors of oxidative phosphorylation.	Oxygen	41-47	erythropoietin	Rattus norvegicus	85-88
17107086-1	2006	The first synthesis of sulfonamide and sulfonate analogues of a sulfated carbohydrate in which the ester oxygen of the sulfate is replaced with a CHF or CF2 group is reported.	Oxygen	105-111	ATPase H+ transporting accessory protein 1	Homo sapiens	153-156
1820025-1	1991	An N-ethyl-N-nitrosourea (ENU)-induced mutation in the Hbb-b1 gene of the mouse hemoglobin-beta complex (Hbb) has been shown to result in a high-oxygen affinity hemoglobin, homologous with hemoglobin Rainier in man (Peters, J., et al., Genetics 110:709, 1985).	Oxygen	145-151	hemoglobin, beta adult major chain	Mus musculus	55-61
17077881-4	2006	Depending on the size and concentration of oxygen donor ligands, used as chemical scissors on BaI2, three-, two-, one- and zero-dimensional derived adducts of BaI2 are obtained, comparable to a structural genealogy tree for BaI2.	Oxygen	43-49	adhesion G protein-coupled receptor B2	Homo sapiens	94-98
17077881-4	2006	Depending on the size and concentration of oxygen donor ligands, used as chemical scissors on BaI2, three-, two-, one- and zero-dimensional derived adducts of BaI2 are obtained, comparable to a structural genealogy tree for BaI2.	Oxygen	43-49	adhesion G protein-coupled receptor B2	Homo sapiens	159-163
17077881-4	2006	Depending on the size and concentration of oxygen donor ligands, used as chemical scissors on BaI2, three-, two-, one- and zero-dimensional derived adducts of BaI2 are obtained, comparable to a structural genealogy tree for BaI2.	Oxygen	43-49	adhesion G protein-coupled receptor B2	Homo sapiens	159-163
17057866-0	2006	Mononuclear copper(II)-hydroperoxo complex derived from reaction of copper(I) complex with dioxygen as a model of DbetaM and PHM.	Oxygen	91-99	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	125-128
17057866-1	2006	A mononuclear copper(II)-hydroperoxo species has been generated by the reaction of Cu(I)-H2BPPA complex with dioxygen, which illustrates the enzymatic reaction process of the CuB site in the DbetaM and PHM.	Oxygen	109-117	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	202-205
18326806-0	2008	Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger.	Oxygen	48-54	nitric oxide synthase 1	Rattus norvegicus	23-27
18326806-3	2008	Our prior studies have shown that cerebral neuronal NO synthase (nNOS) is essential for [NO] responses to decreased oxygen tension and that endothelial NO synthase (eNOS) is of little consequence.	Oxygen	116-122	nitric oxide synthase 1	Rattus norvegicus	65-69
18326806-11	2008	Therefore, nNOS activation secondary to Na(+)-K(+)-2Cl(-) cotransporter and Na(+)/Ca(2+) exchanger functions are key to cerebral vascular oxygen responses.	Oxygen	138-144	nitric oxide synthase 1	Rattus norvegicus	11-15
18218698-3	2008	Administration of the PPARgamma agonist rosiglitazone (15 mg/kg.d) for 7 d to male Sprague Dawley rats increased food intake (10%), feed efficiency (31%), weight gain (45%), spontaneous motor activity (60%), and BAT and WAT mass and reduced whole-body oxygen consumption.	Oxygen	252-258	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	22-31
19099751-9	2008	RESULTS: Exposure to oxygen for 4 d, 7 d, and 14 d resulted in increased mRNA levels of MMP-2 and MMP-9 compared with air-exposed control group (P &lt; 0.01 for all).	Oxygen	21-27	matrix metallopeptidase 9	Rattus norvegicus	98-103
19099751-10	2008	The mean protein levels of active MMP-2 and pro/active MMP-9 after exposure to O2 were higher than air control groups on each experimental day (P &lt; 0.01 or &lt; 0.05).	Oxygen	79-81	matrix metallopeptidase 9	Rattus norvegicus	55-60
19099751-15	2008	CONCLUSION: Hyperoxia exposure elevated the expression of MMP-2 and MMP-9 markedly, which played a role in oxygen-induced lung injury.	Oxygen	107-113	matrix metallopeptidase 9	Rattus norvegicus	68-73
17059405-8	2006	The WRKY33 transcript is induced in response to pathogen infection, or treatment with salicylate or the paraquat herbicide that generates activated oxygen species in exposed cells.	Oxygen	148-154	WRKY DNA-binding protein 33	Arabidopsis thaliana	4-10
1370059-5	1991	The depression of specific G-CSF productivity per cell under the batch culture conditions was overcome by using a perfusion culture system, Biofermenter (Sato, 1983) with modifications of nutrients supplementation by a dialysis membrane and/or dissolved oxygen (DO) supplementation by microsilicone fibers.	Oxygen	254-260	colony stimulating factor 3	Homo sapiens	27-32
16955518-3	2006	The key step is the understanding of the electronic response of SnO(2) in the presence of background oxygen.	Oxygen	101-107	strawberry notch homolog 2	Homo sapiens	64-67
18393449-1	2008	The flavoprotein quiescin-sulfhydryl oxidase (QSOX) rapidly inserts disulfide bonds into unfolded, reduced proteins with the concomitant reduction of oxygen to hydrogen peroxide.	Oxygen	150-156	quiescin sulfhydryl oxidase 1	Homo sapiens	17-44
18393449-1	2008	The flavoprotein quiescin-sulfhydryl oxidase (QSOX) rapidly inserts disulfide bonds into unfolded, reduced proteins with the concomitant reduction of oxygen to hydrogen peroxide.	Oxygen	150-156	quiescin sulfhydryl oxidase 1	Homo sapiens	46-50
18323529-6	2008	These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation.	Oxygen	199-205	long intergenic non-protein coding RNA 914	Homo sapiens	24-28
16955518-4	2006	For a long time, oxygen interaction with SnO(2) has been treated within the framework of the "ionosorption theory".	Oxygen	17-23	strawberry notch homolog 2	Homo sapiens	41-44
1933367-4	1991	In 42 cells, switching to air (about 20% O2) lowered pHi in 60% of them by as much as 0.14 unit (mean decrease, 0.05).	Oxygen	41-43	glucose-6-phosphate isomerase	Rattus norvegicus	53-56
17003342-7	2006	These findings demonstrate that PPARgamma agonism redistributes fat by stimulating the lipid uptake and esterification potential in subcutaneous fat, which more than compensates for increased O2 consumption; conversely, lipid uptake is minimally altered and energy expenditure is greatly increased in visceral fat, with consequent reduction in fat accumulation.	Oxygen	192-194	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	32-41
18423190-1	2008	The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein.	Oxygen	115-117	von Hippel-Lindau tumor suppressor	Mus musculus	143-160
1933367-6	1991	Application of 2.5% CO2 in 50% O2 (balance N2) reduced the pHi in 90% of 47 cells by as much as 0.44 unit (mean decrease, 0.14).	Oxygen	21-23	glucose-6-phosphate isomerase	Rattus norvegicus	59-62
1952070-2	1991	The enzymatic depletion of oxygen in solutions of hemoglobin and myoglobin was initiated by flowing the hemeproteins with the enzyme against a solution of the hemeproteins containing the appropriate substrate.	Oxygen	27-33	myoglobin	Homo sapiens	65-74
17564793-2	2008	In this paper we discuss, how modernisation of the wastewater treatment plant at the mills, and process investments in the Best Available Techniques (BAT) for effluent treatment, have decreased the effluent discharges of biological oxygen demand (BOD), chemical oxygen demand (COD), total phosphorus (Tot-P), total nitrogen (TOT-N), total suspended solids (TSS) and adsorbable organically bound halogens (AOX) from the mills since 1988.	Oxygen	232-238	acyl-CoA oxidase 1	Homo sapiens	405-408
17050190-4	2006	gp91phox belongs to the NADPH oxidase (Nox) family, which contains the entire electron-transporting apparatus from NADPH to molecular oxygen.	Oxygen	134-140	cytochrome b-245 beta chain	Homo sapiens	0-8
1648478-3	1991	Inactivation of the ABC1 gene is not lethal to the cell but leads to a respiratory defect: no oxygen uptake and no growth on non-fermentable media.	Oxygen	94-100	protein kinase COQ8	Saccharomyces cerevisiae S288C	20-24
16956297-3	2006	Bisphosphonates, pyrophosphate analogues in which the oxygen bridge between the two phosphorus atoms has been replaced by a carbon substituted with different side chains, are able to inhibit the FPPS enzyme.	Oxygen	54-60	farnesyl diphosphate synthase	Homo sapiens	195-199
18481000-14	2008	We are led to conclude that exposure to high concentrations of oxygen can significantly change the expression of Cytb and ATPase6, 8, which results in uncoupling of oxidative phosphorylation in mitochondrial respiration chain, and plays an important role in the mechanism of hyperoxia-induced lung injury.	Oxygen	63-69	cytochrome b, mitochondrial	Rattus norvegicus	113-117
18206401-0	2008	Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects.	Oxygen	11-17	vascular endothelial growth factor A	Oryctolagus cuniculus	39-73
18206401-0	2008	Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects.	Oxygen	11-17	vascular endothelial growth factor A	Oryctolagus cuniculus	75-79
18335062-9	2008	Basal oxygen consumption was increased almost 3-fold in white adipose tissue of HSL null mice and was accompanied by increased uncoupling activity.	Oxygen	6-12	lipase, hormone sensitive	Mus musculus	80-83
16953299-1	2006	When manganese stabilizing protein (MSP) was treated with 0.5 mM N-succinimidyl propionate (NSP), the rebinding ability and oxygen-releasing capabilities of the modified MSP were not altered, in spite of changes of MSP surface Lys residues.	Oxygen	124-130	microseminoprotein beta	Homo sapiens	36-39
16953299-1	2006	When manganese stabilizing protein (MSP) was treated with 0.5 mM N-succinimidyl propionate (NSP), the rebinding ability and oxygen-releasing capabilities of the modified MSP were not altered, in spite of changes of MSP surface Lys residues.	Oxygen	124-130	microseminoprotein beta	Homo sapiens	170-173
16953299-1	2006	When manganese stabilizing protein (MSP) was treated with 0.5 mM N-succinimidyl propionate (NSP), the rebinding ability and oxygen-releasing capabilities of the modified MSP were not altered, in spite of changes of MSP surface Lys residues.	Oxygen	124-130	microseminoprotein beta	Homo sapiens	170-173
1896258-3	1991	Cells from IL-3/GM-CSF cultures showed progressively increasing oxygen metabolism and locomotive capabilities over time, which became equivalent to peripheral blood neutrophils at wk 4 and 3, respectively.	Oxygen	64-70	interleukin 3	Homo sapiens	11-15
16735604-6	2006	Neutrophil reactive oxygen intermediate production in response to bacteria was also increased by opsonization with SAA.	Oxygen	20-26	serum amyloid A1 cluster	Homo sapiens	115-118
16728520-0	2006	Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	95-105
18222471-6	2008	Molecular modeling of the E122W and E122Y mutants revealed that the tryptophan ring edge and tyrosine hydroxyl are positioned proximal to the helical break in TM5 introduced by the conserved Pro211(5.50) and may stabilize the helix by interacting favorably with the unpaired carbonyl oxygen of Val206(5.45).	Oxygen	284-290	tropomyosin 3	Homo sapiens	159-162
1896258-3	1991	Cells from IL-3/GM-CSF cultures showed progressively increasing oxygen metabolism and locomotive capabilities over time, which became equivalent to peripheral blood neutrophils at wk 4 and 3, respectively.	Oxygen	64-70	colony stimulating factor 2	Homo sapiens	16-22
18158911-5	2008	Nitric oxide has been reported to react easily with oxygen captured in hemoglobin to form nitrate, but not toxic free radicals, which may result in production of methemoglobin for the cytochrome b5 to regenerate functional ferrous hemoglobin.	Oxygen	52-58	hemoglobin subunit gamma 2	Homo sapiens	162-175
16728520-2	2006	Therefore, the purpose of this study was to test the hypothesis that oxygen-induced neuroprotection after neonatal hypoxia-ischemia involves alterations in the expression of HIF-1alpha.	Oxygen	69-75	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	174-184
16728520-10	2006	Therefore, the alteration of the HIF-1alpha phenotype by a single oxygen treatment may be one of the underlying mechanisms for the observed oxygen-induced neuroprotection seen when oxygen is administered after a neonatal hypoxic-ischemic insult.	Oxygen	66-72	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
1896258-5	1991	IL-3/G-CSF cultures produced cells with progressive increases in oxygen metabolism, locomotion, and phagocytosis.	Oxygen	65-71	interleukin 3	Homo sapiens	0-4
16728520-10	2006	Therefore, the alteration of the HIF-1alpha phenotype by a single oxygen treatment may be one of the underlying mechanisms for the observed oxygen-induced neuroprotection seen when oxygen is administered after a neonatal hypoxic-ischemic insult.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
16728520-10	2006	Therefore, the alteration of the HIF-1alpha phenotype by a single oxygen treatment may be one of the underlying mechanisms for the observed oxygen-induced neuroprotection seen when oxygen is administered after a neonatal hypoxic-ischemic insult.	Oxygen	140-146	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
1896258-5	1991	IL-3/G-CSF cultures produced cells with progressive increases in oxygen metabolism, locomotion, and phagocytosis.	Oxygen	65-71	colony stimulating factor 3	Homo sapiens	5-10
18223675-4	2008	The aim of this study was to assess the protective role of H(2)O(2) and modification in its endogenous production on the electrophysiological and morphological changes induced by oxygen/glucose deprivation (OGD) on CA1 hippocampal neurons.	Oxygen	179-185	carbonic anhydrase 1	Homo sapiens	215-218
2046677-3	1991	Furthermore, we have shown that the CYB2 promoter contains one cis negative regulatory region and two heme-dependent positive regions, one of which is controlled by the transcriptional regulator CYP1 (HAP1) which is involved in the modulation of the expression of several oxygen-regulated genes.	Oxygen	272-278	Hap1p	Saccharomyces cerevisiae S288C	195-199
18234679-10	2008	MAP and PBr(O2) in both groups decreased after haemorrhage.	Oxygen	12-14	translocator protein	Rattus norvegicus	8-11
18234679-11	2008	Resuscitation with stored blood returned MAP [92 (SD 16) mm Hg] and PBr(O2) [3.2 (0.7) kPa] to baseline, whereas rCBF remained stable [1.2 (0.1)].	Oxygen	72-74	translocator protein	Rattus norvegicus	68-71
18234679-14	2008	CONCLUSIONS: Although resuscitation with stored blood restored cerebral oxygen delivery to baseline, fresh blood produced a greater increase in both PBr(O2) and rCBF.	Oxygen	153-155	translocator protein	Rattus norvegicus	149-152
18245276-2	2008	It has two oxygen-sensitive [Fe-Fe] hydrogenases (EC 1.12.7.2) that are coupled to photosynthesis and, in addition, a formate- and ethanol-producing fermentative metabolism, which was proposed to be initiated by pyruvate formate-lyase (Pfl; EC 2.3.1.54).	Oxygen	11-17	uncharacterized protein	Chlamydomonas reinhardtii	236-239
16598418-5	2006	Our results show that p-CREB levels are significantly elevated under 1% oxygen, whereas the total CREB concentration remains unchanged.	Oxygen	72-78	cAMP responsive element binding protein 1	Homo sapiens	24-28
2046677-3	1991	Furthermore, we have shown that the CYB2 promoter contains one cis negative regulatory region and two heme-dependent positive regions, one of which is controlled by the transcriptional regulator CYP1 (HAP1) which is involved in the modulation of the expression of several oxygen-regulated genes.	Oxygen	272-278	Hap1p	Saccharomyces cerevisiae S288C	201-205
17101458-1	2006	Iron (Fe) is an essential element that is imperative for the redox-driven processes of oxygen transport, electron transport, and DNA synthesis.	Oxygen	87-93	general transcription factor IIE subunit 1	Homo sapiens	6-8
2040698-3	1991	During continuous exposure to oxygen, both control and transgenic animals who successfully adapted to hyperoxia showed increased activity of lung antioxidant enzymes such as glutathione peroxidase (GPX), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PD), whereas superoxide dismutase activity remained unchanged.	Oxygen	30-36	glucose-6-phosphate dehydrogenase 2	Mus musculus	236-269
16928088-0	2006	Discovery of a practical direct O2-coupled Wacker oxidation with Pd[(-)-sparteine]Cl2.	Oxygen	32-34	endogenous retrovirus group W member 5	Homo sapiens	82-85
16884302-5	2006	While retention of the maleimide ring and pendant 4-phenyl group is necessary for potency, replacement of the carbazole nitrogen by oxygen is well tolerated and results in improved Wee1 selectivity against the related checkpoint kinase Chk1.	Oxygen	132-138	WEE1 G2 checkpoint kinase	Homo sapiens	181-185
18288196-3	2008	Here we show that the transcriptional coactivator PGC-1alpha (peroxisome-proliferator-activated receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo.	Oxygen	211-217	vascular endothelial growth factor A	Mus musculus	255-259
18154950-0	2008	Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets.	Oxygen	90-96	matrix metallopeptidase 9	Homo sapiens	21-47
18266131-3	2008	The authors observed significant up-regulation of IL-8 and MCP-1 expression in A549 cells that was independent from the IL-1 receptor pathway but was modified by oxygen tension.	Oxygen	162-168	chemokine (C-C motif) ligand 2	Mus musculus	59-64
2040698-3	1991	During continuous exposure to oxygen, both control and transgenic animals who successfully adapted to hyperoxia showed increased activity of lung antioxidant enzymes such as glutathione peroxidase (GPX), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PD), whereas superoxide dismutase activity remained unchanged.	Oxygen	30-36	glucose-6-phosphate dehydrogenase 2	Mus musculus	271-275
18155142-8	2008	The expression of p53, p21 and Mdm2 in both cytotrophoblast and stromal cells was increased following culture in 1% O(2).	Oxygen	116-120	MDM2 proto-oncogene	Homo sapiens	31-35
16880565-2	2006	MIOX utilizes an Fe(II)/Fe(III) binuclear iron centre for the dioxygen-dependent cleavage of the C1-C6 bond in MI.	Oxygen	62-70	myo-inositol oxygenase	Mus musculus	0-4
1850188-3	1991	Furthermore, the beneficial effects of ACE inhibitors that contain a sulfhydryl group may be due in part to the ability of thiol compounds to act as nonspecific antioxidants or direct scavengers of cytotoxic oxygen-derived free radicals.	Oxygen	208-214	angiotensin I converting enzyme	Canis lupus familiaris	39-42
17102090-8	2006	Thus, from a phenotypic perspective, succinate dehydrogenase (SDH) appears to be a well-supported oxygen sensor candidate.	Oxygen	98-104	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	37-60
17102090-8	2006	Thus, from a phenotypic perspective, succinate dehydrogenase (SDH) appears to be a well-supported oxygen sensor candidate.	Oxygen	98-104	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	62-65
18067275-6	2008	We found that the sulfur atom of BLT-1 was crucially important for its inhibitory activity, because changing it to an oxygen atom resulted in the isostructural, but essentially inactive, semicarbazone derivative BLT-1sc.	Oxygen	118-124	leukotriene B4 receptor	Homo sapiens	33-38
2022730-7	1991	We conclude that (a) human neutrophil cathepsin G is an important antimicrobial system against the Capnocytophaga, (b) the bactericidal activity of cathepsin G against Capnocytophaga is oxygen independent, and (c) an intact enzyme active site is involved in the killing of C. sputigena but not E. coli.	Oxygen	186-192	cathepsin G	Homo sapiens	38-49
18162550-4	2008	Via myocardium-specific induction (and, in turn, deinduction) of a VEGF-sequestering soluble receptor, we show that VEGF is indispensable for adjusting the coronary vasculature to match increased oxygen consumption and exploit this finding to generate a hypoperfused heart.	Oxygen	196-202	vascular endothelial growth factor A	Mus musculus	67-71
18162550-4	2008	Via myocardium-specific induction (and, in turn, deinduction) of a VEGF-sequestering soluble receptor, we show that VEGF is indispensable for adjusting the coronary vasculature to match increased oxygen consumption and exploit this finding to generate a hypoperfused heart.	Oxygen	196-202	vascular endothelial growth factor A	Mus musculus	116-120
17015265-2	2006	We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1).	Oxygen	60-62	mitogen activated protein kinase kinase 4	Rattus norvegicus	224-228
17015265-2	2006	We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1).	Oxygen	60-62	mitogen activated protein kinase kinase 7	Rattus norvegicus	238-242
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	82-88	proliferating cell nuclear antigen	Rattus norvegicus	4-8
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	131-137	proliferating cell nuclear antigen	Rattus norvegicus	4-8
2022730-7	1991	We conclude that (a) human neutrophil cathepsin G is an important antimicrobial system against the Capnocytophaga, (b) the bactericidal activity of cathepsin G against Capnocytophaga is oxygen independent, and (c) an intact enzyme active site is involved in the killing of C. sputigena but not E. coli.	Oxygen	186-192	cathepsin G	Homo sapiens	148-159
18290312-0	2008	Uncoupling protein-2 in diabetic kidneys: increased protein expression correlates to increased non-transport related oxygen consumption.	Oxygen	117-123	uncoupling protein 2	Rattus norvegicus	0-20
18290312-8	2008	We conclude that sustained STZ-induced hyperglycemia increases the kidney levels of mitochondrial UCP-2, which could explain the previously reported increase in non-transport related oxygen consumption in diabetic kidneys.	Oxygen	183-189	uncoupling protein 2	Rattus norvegicus	98-103
1649989-0	1991	Oxygen-dependent erythropoietin production by the isolated perfused rat kidney.	Oxygen	0-6	erythropoietin	Rattus norvegicus	17-31
18290322-5	2008	Hypoxia-inducible factor (HIF)-1alpha, the master transcriptional regulator of the hypoxic response, as well as certain downstream genes, e.g., glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX, have been considered to be suitable as surrogate biomarkers of hypoxia due to their tight regulation by O2 levels under certain, well-defined in vitro conditions.	Oxygen	309-311	solute carrier family 2 member 1	Homo sapiens	144-172
16846785-17	2006	PAF and TxA(2) decrease hepatic oxygen consumption, whereas LTD(4) causes a biphasic change of it.	Oxygen	32-38	PCNA clamp associated factor	Rattus norvegicus	0-3
1649989-3	1991	The erythropoietin production rate was inversely related to the oxygen pressure in the perfusate and increased from 0.17 to 1.85 U erythropoietin h-1 g kidney-1 when arterial PO2 was lowered from 500 mmHg to 30 mmHg.	Oxygen	64-70	erythropoietin	Rattus norvegicus	4-18
16622835-5	2006	As an example, N-myc downstream regulated gene 1 (NDRG1), a putative differentiation-related gene, was up-regulated in both 2% O2- and CoCl2-treated U937 cells.	Oxygen	127-129	N-myc downstream regulated 1	Homo sapiens	15-48
16622835-5	2006	As an example, N-myc downstream regulated gene 1 (NDRG1), a putative differentiation-related gene, was up-regulated in both 2% O2- and CoCl2-treated U937 cells.	Oxygen	127-129	N-myc downstream regulated 1	Homo sapiens	50-55
16407835-3	2006	A large number of disease-causing mutations in either the alpha or beta domain renders HIFalpha stable irrespective of oxygen tension, leading to the upregulation of numerous HIF-target genes, such as GLUT1 and VEGF.	Oxygen	119-125	solute carrier family 2 member 1	Homo sapiens	201-206
17954702-2	2008	These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.	Oxygen	86-92	caspase 3	Mus musculus	117-126
18978955-1	2008	PURPOSE: To investigate whether vector-based vascular endothelial growth factor 165 (VEGF)(165) targeted siRNA expression system (pSilencer(siVEGF)) could inhibit VEGF(165) expression in vitro and suppresses retinal neovascularization in the murine model of oxygen-induced retinopathy.	Oxygen	258-264	vascular endothelial growth factor A	Mus musculus	45-83
18978955-1	2008	PURPOSE: To investigate whether vector-based vascular endothelial growth factor 165 (VEGF)(165) targeted siRNA expression system (pSilencer(siVEGF)) could inhibit VEGF(165) expression in vitro and suppresses retinal neovascularization in the murine model of oxygen-induced retinopathy.	Oxygen	258-264	vascular endothelial growth factor A	Mus musculus	85-89
2030477-2	1991	We hypothesized graded effects of alveolar (PAO2) and arterial (PaO2) oxygen tension on pulmonary vascular resistance (PVR).	Oxygen	70-76	PVR cell adhesion molecule	Homo sapiens	119-122
18543659-9	2008	therapeutical CPAP was applied only in infants with the necessity in oxygen over 40%, to maintain the saturation between 90 - 95%.	Oxygen	69-75	centromere protein J	Homo sapiens	14-18
18421557-4	2008	There was a correlation between differences in PaCO2 and arterial oxygen saturation during CPAP (R = -0.97, p &lt; 0.01, n = 6).	Oxygen	66-72	centromere protein J	Homo sapiens	91-95
16683773-2	2006	In the oxygen-free form of Hb A, also known as deoxyhemoglobin A (deoxy-Hb A), the hemes are paramagnetic with S = 2.	Oxygen	7-13	sodium voltage-gated channel alpha subunit 2	Homo sapiens	27-31
16683773-2	2006	In the oxygen-free form of Hb A, also known as deoxyhemoglobin A (deoxy-Hb A), the hemes are paramagnetic with S = 2.	Oxygen	7-13	sodium voltage-gated channel alpha subunit 2	Homo sapiens	72-76
1899208-13	1991	Subcutaneous PO2 and PtCO2, and small intestine and sigmoid colon pHi were correlated to total body oxygen transport.	Oxygen	100-106	vasoactive intestinal peptide	Sus scrofa	66-69
16439134-4	2006	Spin adducts from other oxygen- and carbon-centered radicals (e.g., derived from methanol or linoleic acid hydroperoxide) are also described.	Oxygen	24-30	spindlin 1	Homo sapiens	0-4
18052134-4	2007	The calculated results suggest a proton-transferred hydrogen bond between HO2 and H2O in H3O3+ wherein a proton is partially transferred to H2O producing the O2...H3O+ structure.	Oxygen	75-77	H3 clustered histone 15	Homo sapiens	89-92
18052134-5	2007	The basis set superposition error and zero-point energy corrected results indicate that the H3O3+ system is energetically more stable in the triplet state; however, the singlet state of H3O3+ is more stable with respect to its dissociation into H3O+ and singlet O2.	Oxygen	262-264	H3 clustered histone 15	Homo sapiens	92-95
18052134-6	2007	Since the resulting proton-transferred hydrogen-bonded complex (O2...H3O+) consists of weakly bound molecular oxygen, it might have important implications in various chemical processes and aquatic life systems.	Oxygen	64-66	H3 clustered histone 15	Homo sapiens	69-72
18052134-6	2007	Since the resulting proton-transferred hydrogen-bonded complex (O2...H3O+) consists of weakly bound molecular oxygen, it might have important implications in various chemical processes and aquatic life systems.	Oxygen	110-116	H3 clustered histone 15	Homo sapiens	69-72
18052171-0	2007	Spin accommodation and reactivity of aluminum based clusters with O2.	Oxygen	66-68	spindlin 1	Homo sapiens	0-4
16710171-2	2006	This study was performed to determine the temporal and spatial expression of F4/80 (F4/80+) positive microglia/macrophages (MG/MAC) in areas of retinal damage in the mouse model of oxygen-induced retinopathy.	Oxygen	181-187	adhesion G protein-coupled receptor E1	Mus musculus	77-82
18052171-1	2007	It is shown that spin accommodation plays a determining role in the reactivity of aluminum based anion clusters with oxygen.	Oxygen	117-123	spindlin 1	Homo sapiens	17-21
11537125-2	1991	The European EVA Space Suit will be an anthropomorphic system with an internal pressure of 500 hPa of pure oxygen.	Oxygen	107-113	myelin protein zero like 2	Homo sapiens	13-16
18052171-3	2007	The reactivity of even electron clusters is governed by a spin transfer to the singlet cluster through filling of the spin down antibonding orbitals on triplet oxygen.	Oxygen	160-166	spindlin 1	Homo sapiens	58-62
18052171-3	2007	The reactivity of even electron clusters is governed by a spin transfer to the singlet cluster through filling of the spin down antibonding orbitals on triplet oxygen.	Oxygen	160-166	spindlin 1	Homo sapiens	118-122
16710171-2	2006	This study was performed to determine the temporal and spatial expression of F4/80 (F4/80+) positive microglia/macrophages (MG/MAC) in areas of retinal damage in the mouse model of oxygen-induced retinopathy.	Oxygen	181-187	adhesion G protein-coupled receptor E1	Mus musculus	84-89
16645452-7	2006	RESULTS: Twenty minutes of oxygen and glucose deprivation killed approximately 40-60% of neurons in CA3 and dentate in all age groups.	Oxygen	27-33	carbonic anhydrase 3	Rattus norvegicus	100-103
18042705-5	2007	Ngb is a globin family protein found in vertebrate brains that binds oxygen reversibly.	Oxygen	69-75	neuroglobin	Homo sapiens	0-3
30260337-2	1991	Both the C-2 amino and C-1 aldehyde groups in the aminosugar molecules were indispensable for the generation of active oxygen molecules.	Oxygen	119-125	complement C2	Homo sapiens	9-12
18042705-8	2007	However, in contrast to Mb, human Ngb has an intramolecular disulfide bond that affects its oxygen affinity and protein stability.	Oxygen	92-98	neuroglobin	Homo sapiens	34-37
18034646-1	2007	Patients with chronic granulomatous disease (CGD) cannot generate reactive oxygen metabolites, and suffer from severe recurrent infections and dysregulated inflammation.	Oxygen	75-81	cytochrome b-245 beta chain	Homo sapiens	45-48
16817867-5	2006	The results show that ChT, IL-16 and O2(-) levels significantly increased in ischemic CvD patients compared with AD patients and were significantly and positively correlated with IL-18 and O2(-).	Oxygen	37-39	interleukin 18	Homo sapiens	179-184
30260337-2	1991	Both the C-2 amino and C-1 aldehyde groups in the aminosugar molecules were indispensable for the generation of active oxygen molecules.	Oxygen	119-125	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	23-26
1886079-4	1991	To develop agents having enhanced potency and selectivity for the 5-HT1A site, several ring systems offering enhanced conformational rigidity which approximate the oxygen to nitrogen interatomic distances of 8-OH-DPAT and (to a lesser extent) 5-HT were synthesized.	Oxygen	164-170	5-hydroxytryptamine receptor 1A	Homo sapiens	66-72
16478298-0	2006	Rate measurement of the reaction of CF2Cl radicals with O2.	Oxygen	56-58	ATPase H+ transporting accessory protein 1	Homo sapiens	36-39
16633681-3	2006	The rate coefficient for vibrational relaxation of O2(X 3sigma(g)-, nu = 8) by collisions with CF(4), [1.4 +/- 0.3(2sigma)] x 10(-11) cm3 molecule(-1) s(-1), indicates that CF4 is an efficient relaxant of O2(X 3sigma(g)- and that the propensity rule for O2 relaxation suggested by Mack et al.	Oxygen	205-207	immunoglobulin kappa variable 1D-39	Homo sapiens	51-74
16481327-3	2006	In particular, despite similar cytochrome content, under basal conditions, the oxygen consumption of spontaneously immortalized p66(shc-/-) mouse embryonic fibroblasts were lower than similarly maintained wild type cells.	Oxygen	79-85	src homology 2 domain-containing transforming protein C1	Mus musculus	128-131
17982448-4	2007	The oxygen-bound form of nitrite-methemoglobin shows a degree of ferrous nitrogen dioxide (Fe(II)-NO2*) character, so it may rapidly react with NO to form N2O3.	Oxygen	4-10	hemoglobin subunit gamma 2	Homo sapiens	33-46
17957151-3	2007	At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air.	Oxygen	64-66	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	29-32
17512795-0	2007	Long-term oxygen administration reduces plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome.	Oxygen	10-16	adrenomedullin	Homo sapiens	47-61
17512795-3	2007	We further hypothesized that oxygen administration treatment may decrease OSAS-induced hypoxic stress and ADM levels.	Oxygen	29-35	adrenomedullin	Homo sapiens	106-109
17512795-4	2007	METHODS: We examined short-term and long-term oxygen administration effects on circulating ADM in 48 OSAS patients.	Oxygen	46-52	adrenomedullin	Homo sapiens	91-94
17512795-6	2007	We did not observe a significant effect in 2 weeks of oxygen administration on the circulating ADM in the patients, but we observed a significant effect in long-term oxygen administration for more than 3 months on plasma ADM levels.	Oxygen	166-172	adrenomedullin	Homo sapiens	221-224
17512795-7	2007	Long-term oxygen therapy decreased both the magnitude of arterial oxygen desaturation and plasma ADM levels in patients but did not decrease blood pressure.	Oxygen	10-16	adrenomedullin	Homo sapiens	97-100
16481327-3	2006	In particular, despite similar cytochrome content, under basal conditions, the oxygen consumption of spontaneously immortalized p66(shc-/-) mouse embryonic fibroblasts were lower than similarly maintained wild type cells.	Oxygen	79-85	src homology 2 domain-containing transforming protein C1	Mus musculus	132-135
16481327-4	2006	Differences in oxygen consumption were particularly evident under chemically uncoupled conditions, demonstrating that p66(shc-/-) cells have a reduction in both their resting and maximal oxidative capacity.	Oxygen	15-21	src homology 2 domain-containing transforming protein C1	Mus musculus	118-121
16481327-5	2006	We further demonstrate that reconstitution of p66(shc) expression in p66(shc-/-) cells increases oxygen consumption.	Oxygen	97-103	src homology 2 domain-containing transforming protein C1	Mus musculus	46-49
17512795-8	2007	CONCLUSIONS: These observations suggest that long-term oxygen therapy could reduce OSAS-induced nocturnal hypoxemia and plasma ADM levels in patients with OSAS.	Oxygen	55-61	adrenomedullin	Homo sapiens	127-130
2010944-1	1991	To investigate the mechanism of cardiac dysfunction in myocarditis, myoglobin, an intracellular oxygen-transport, was immunohistochemically examined in biopsy specimens obtained from the right side of the ventricular septum and left ventricular free wall in 58 patients with myocarditis and 19 controls.	Oxygen	96-102	myoglobin	Homo sapiens	68-77
18052446-3	2007	At all the investigated surface temperatures, T(S) (300-1400 K), we found the bulk oxygen concentration C(O) to have a strong effect on the integral probability, alpha(H(2) ), of dissociative sticking of H(2) molecules followed by hydrogen solution in the metal lattice: alpha(H(2) ) monotonically decreased by orders of magnitude with increasing C(O) from 0.03 to 1.5 at.	Oxygen	83-89	relaxin 2	Homo sapiens	162-172
18052446-3	2007	At all the investigated surface temperatures, T(S) (300-1400 K), we found the bulk oxygen concentration C(O) to have a strong effect on the integral probability, alpha(H(2) ), of dissociative sticking of H(2) molecules followed by hydrogen solution in the metal lattice: alpha(H(2) ) monotonically decreased by orders of magnitude with increasing C(O) from 0.03 to 1.5 at.	Oxygen	83-89	relaxin 2	Homo sapiens	271-281
16481327-5	2006	We further demonstrate that reconstitution of p66(shc) expression in p66(shc-/-) cells increases oxygen consumption.	Oxygen	97-103	src homology 2 domain-containing transforming protein C1	Mus musculus	50-53
16481327-5	2006	We further demonstrate that reconstitution of p66(shc) expression in p66(shc-/-) cells increases oxygen consumption.	Oxygen	97-103	src homology 2 domain-containing transforming protein C1	Mus musculus	69-72
16481327-5	2006	We further demonstrate that reconstitution of p66(shc) expression in p66(shc-/-) cells increases oxygen consumption.	Oxygen	97-103	src homology 2 domain-containing transforming protein C1	Mus musculus	73-76
2176871-15	1990	We further report the 17O hyperfine tensor parameters of the C-2 carboxyl oxygen of substrate bound to the cluster as determined by the field dependence of the 17O ENDOR signals.	Oxygen	74-80	complement C2	Homo sapiens	61-64
16611807-2	2006	We show that the COMT Met158 allele and the DAT 3" variable number of tandem repeat 10-repeat allele are independently associated in healthy humans with more focused neuronal activity (as measured with blood oxygen level-dependent functional magnetic resonance imaging) in the working memory cortical network, including the prefrontal cortex.	Oxygen	208-214	solute carrier family 6 member 3	Homo sapiens	44-47
17958423-8	2007	A CH2Cl2 solution under 0.30 atm of H2 and 0.13 atm of O2 converted to H2O in the presence of 1 and 10 mol % of H(OEt2)2BAr(F)4 (BAr(F)4- = B(C6H3-3,5-(CF3)2)4-).	Oxygen	55-57	relaxin 2	Homo sapiens	36-44
17884817-3	2007	We report that low oxygen concentrations and TNFalpha enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 (HIF-1) to the 5" promoter region.	Oxygen	19-25	ADAM metallopeptidase domain 17	Homo sapiens	62-66
2231727-11	1990	The third Ca2+ is also seven-co-ordinated, to five oxygen atoms belonging to three different oncomodulin molecules and to two water molecules which form hydrogen bonds to a fourth oncomodulin; thus, this intermolecular Ca2+ and its equivalents interlink the molecules into zigzag layers normal to the b axis with a spacing of b/2 or 32.14 A.	Oxygen	51-57	oncomodulin	Rattus norvegicus	93-104
17684156-0	2007	Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.	Oxygen	0-6	activating transcription factor 4	Homo sapiens	17-22
17684156-0	2007	Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.	Oxygen	0-6	egl-9 family hypoxia inducible factor 3	Homo sapiens	52-56
17684156-0	2007	Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.	Oxygen	57-63	activating transcription factor 4	Homo sapiens	17-22
17684156-0	2007	Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.	Oxygen	57-63	egl-9 family hypoxia inducible factor 3	Homo sapiens	52-56
17684156-2	2007	Here, we identified the zipper II domain of ATF-4 to interact with the oxygen sensor prolyl-4-hydroxylase domain 3 (PHD3).	Oxygen	71-77	activating transcription factor 4	Homo sapiens	44-49
17684156-2	2007	Here, we identified the zipper II domain of ATF-4 to interact with the oxygen sensor prolyl-4-hydroxylase domain 3 (PHD3).	Oxygen	71-77	egl-9 family hypoxia inducible factor 3	Homo sapiens	85-114
17684156-2	2007	Here, we identified the zipper II domain of ATF-4 to interact with the oxygen sensor prolyl-4-hydroxylase domain 3 (PHD3).	Oxygen	71-77	egl-9 family hypoxia inducible factor 3	Homo sapiens	116-120
17920049-1	2007	Hypoxia inducible factor-1alpha (HIF-1alpha) plays an important role in maintaining oxygen equilibrium.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
17920049-1	2007	Hypoxia inducible factor-1alpha (HIF-1alpha) plays an important role in maintaining oxygen equilibrium.	Oxygen	84-90	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
16476401-2	2006	Oxidation of these substrates by this reagent was analogous to oxidation by tyrosinase with molecular oxygen, although the procedure showed several advantages over the enzymatic method in that oxidation took place almost immediately and quinone stability was favored because no substrate remained.	Oxygen	102-108	tyrosinase	Homo sapiens	76-86
16084091-3	2006	We studied the altered activation and tyrosine phosphorylation of STATs under hypoxic conditions (2% O2) or desferrioxamine (DFO) treatment in mouse mammary epithelial cells (HC11) and a human breast cancer cell line (MCF-7).	Oxygen	101-103	signal transducer and activator of transcription 1	Homo sapiens	66-71
16384869-0	2006	Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy.	Oxygen	15-21	prokineticin 1	Homo sapiens	36-94
16384869-0	2006	Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy.	Oxygen	15-21	prokineticin 1	Homo sapiens	95-109
16384869-12	2006	The expression pattern of EG-VEGF, its regulation by oxygen tension, and its complementary localization to that of VEGF suggest that this new factor might also be deregulated in preeclampsia.	Oxygen	53-59	prokineticin 1	Homo sapiens	26-33
2231727-11	1990	The third Ca2+ is also seven-co-ordinated, to five oxygen atoms belonging to three different oncomodulin molecules and to two water molecules which form hydrogen bonds to a fourth oncomodulin; thus, this intermolecular Ca2+ and its equivalents interlink the molecules into zigzag layers normal to the b axis with a spacing of b/2 or 32.14 A.	Oxygen	51-57	oncomodulin	Rattus norvegicus	180-191
16537898-1	2006	The tumor suppressor von Hippel-Lindau protein (pVHL) is critical for cellular molecular oxygen sensing, acting to target degradation of the hypoxia-inducible factor alpha transcription factor subunits under normoxic conditions.	Oxygen	89-95	von Hippel-Lindau tumor suppressor	Mus musculus	48-52
17760507-7	2007	NCX-4016 also suppressed oxygen consumption, decreased transendothelial electrical resistance (EC barrier dysfunction), and induced actin cytoskeletal reorganization in BLMVECs.	Oxygen	25-31	T cell leukemia homeobox 2	Homo sapiens	0-3
15374470-5	1990	The mechanism of this competition is, however, not a direct reaction, but it is based on the rather quick autoxidation of the dissolved ID-H generating O2(-*) radicals.	Oxygen	152-154	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	136-140
18225594-11	2007	RESULTS: Reduced O2 supply promoted expression of HIF-1alpha and VEGF.	Oxygen	17-19	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	50-60
17658597-12	2007	Furthermore, expression of Hif-2alpha and the HIF target genes: asHif-1alpha, Vegf and Slc2a1 were reduced under low oxygen with the addition of IGF-II.	Oxygen	117-123	vascular endothelial growth factor A	Mus musculus	78-82
16507596-2	2006	We show that prooxidants (menadione, hydrogen peroxide) as well as chemical (CoCl2) and physiological (1% O2) hypoxia increased CT-1 as well as HIF-1alpha protein and mRNA expression in embryoid bodies, indicating that CT-1 expression is regulated by reactive oxygen species (ROS) and hypoxia.	Oxygen	106-108	cardiotrophin 1	Mus musculus	128-132
16507596-2	2006	We show that prooxidants (menadione, hydrogen peroxide) as well as chemical (CoCl2) and physiological (1% O2) hypoxia increased CT-1 as well as HIF-1alpha protein and mRNA expression in embryoid bodies, indicating that CT-1 expression is regulated by reactive oxygen species (ROS) and hypoxia.	Oxygen	106-108	cardiotrophin 1	Mus musculus	219-223
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	Oxygen	51-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	101-105
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	Oxygen	51-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	158-162
17973831-7	2007	The difference in CSLF blood flow in the nasal ONH between the endothelin-1 (ET-1) treated right eye and the normal left eye of the same individual monkeys was significantly greater than the difference in blood flow between the Sham-treated right eye and the normal left eye in control animals under the conditions of carbogen and oxygen inhalation.	Oxygen	331-337	endothelin 1	Macaca mulatta	63-75
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	Oxygen	51-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	158-162
17973831-7	2007	The difference in CSLF blood flow in the nasal ONH between the endothelin-1 (ET-1) treated right eye and the normal left eye of the same individual monkeys was significantly greater than the difference in blood flow between the Sham-treated right eye and the normal left eye in control animals under the conditions of carbogen and oxygen inhalation.	Oxygen	331-337	endothelin 1	Macaca mulatta	77-81
2168838-6	1990	Human GM-CSF also primed dog granulocytes for increased production of reactive oxygen metabolites in response to either phorbolmyristic acetate-or zymosan-activated dog serum.	Oxygen	79-85	colony stimulating factor 2	Homo sapiens	6-12
17883942-0	2007	Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation.	Oxygen	66-72	protein kinase C, gamma	Rattus norvegicus	26-34
2170337-11	1990	It thus appears that ArcB senses the presence of O2 by level of an electron transport component in reduced form or that of an nonautoxidizable compound linked to the process by a redox reaction, whereas Fnr senses O2 by a different mechanism.	Oxygen	49-51	hypothetical protein	Escherichia coli	21-25
17902103-1	2007	The main singlet molecular oxygen ((1)O(2)) oxidation products of free 2"-deoxyguanosine (dGuo) in aqueous solution were identified as a pair of diastereomeric spiroiminodihydantoin 2"-deoxyribonucleosides (dSp) together with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo).	Oxygen	27-33	dsp	Drosophila melanogaster	207-210
2283670-6	1990	TFEC (1 mM) increased cytosolic free calcium levels 36%, had no effect on basal oxygen consumption, and decreased nystatin-stimulated oxygen consumption 30% after 5 minutes.	Oxygen	134-140	transcription factor EC	Rattus norvegicus	0-4
17623038-8	2007	Hypoxia inhibited cytochrome oxidase activity in the cultures, but a selective nNOS inhibitor prevented this inhibition, indicating NO from nNOS was inhibiting cytochrome oxidase in competition with oxygen.	Oxygen	199-205	nitric oxide synthase 1	Rattus norvegicus	79-83
17623038-8	2007	Hypoxia inhibited cytochrome oxidase activity in the cultures, but a selective nNOS inhibitor prevented this inhibition, indicating NO from nNOS was inhibiting cytochrome oxidase in competition with oxygen.	Oxygen	199-205	nitric oxide synthase 1	Rattus norvegicus	140-144
17622572-8	2007	Renal hypoxia-inducible factor (HIF)-1alpha, whose activity strictly depends on the partial pressure of oxygen increased over time, and it correlated inversely with circulating ferrous PolyHbBv in both species.	Oxygen	104-110	hypoxia-inducible factor 1-alpha	Cavia porcellus	6-43
17601514-3	2007	In this regard, C-glycosides, in which the pseudoanomeric methylene is replaced with a difluoromethylene group, are interesting because the CF2 group is more of an isopolar replacement for oxygen than CH2.	Oxygen	189-195	ATPase H+ transporting accessory protein 1	Homo sapiens	140-143
2283670-9	1990	The increase in cytosolic free calcium levels preceded changes in basal oxygen consumption in tubules exposed to PCBC and TFEC.	Oxygen	72-78	transcription factor EC	Rattus norvegicus	122-126
1704483-1	1990	Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides.	Oxygen	36-42	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	47-50
17636018-0	2007	ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.	Oxygen	86-92	ankyrin repeat and SOCS box containing 4	Homo sapiens	0-4
17636018-4	2007	High levels of ASB4 expression in the embryonic vasculature coincide with drastic increases in oxygen tension as placental blood flow is initiated.	Oxygen	95-101	ankyrin repeat and SOCS box containing 4	Homo sapiens	15-19
17636018-5	2007	However, as vessels mature and oxygen levels stabilize, ASB4 expression is quickly downregulated, suggesting that ASB4 may function to modulate an endothelium-specific response to increasing oxygen tension.	Oxygen	191-197	ankyrin repeat and SOCS box containing 4	Homo sapiens	114-118
17636018-6	2007	Consistent with the hypothesis that ASB4 function is regulated by oxygen concentration, ASB4 interacts with the factor inhibiting HIF1alpha (FIH) and is a substrate for FIH-mediated hydroxylation via an oxygen-dependent mechanism.	Oxygen	66-72	ankyrin repeat and SOCS box containing 4	Homo sapiens	36-40
17636018-6	2007	Consistent with the hypothesis that ASB4 function is regulated by oxygen concentration, ASB4 interacts with the factor inhibiting HIF1alpha (FIH) and is a substrate for FIH-mediated hydroxylation via an oxygen-dependent mechanism.	Oxygen	203-209	ankyrin repeat and SOCS box containing 4	Homo sapiens	88-92
17636018-7	2007	Additionally, overexpression of ASB4 in ES cells promotes differentiation into the vascular lineage in an oxygen-dependent manner.	Oxygen	106-112	ankyrin repeat and SOCS box containing 4	Homo sapiens	32-36
17556599-5	2007	Clonal analysis revealed that apoptosis in 20% oxygen was due to a complete loss of CD133(lo)CD24(lo) multipotent precursors, a substantial loss of CD133(hi)CD24(lo) multipotent precursors, and a failure of remaining CD133(hi)CD24(lo) cells to generate glia.	Oxygen	47-53	prominin 1	Mus musculus	84-89
2394729-2	1990	Ascorbate-reduced dopamine beta-hydroxylase (DBH) is inhibited by CO in a competitive manner with respect to molecular O2.	Oxygen	119-121	dopamine beta-hydroxylase	Homo sapiens	18-43
17556599-5	2007	Clonal analysis revealed that apoptosis in 20% oxygen was due to a complete loss of CD133(lo)CD24(lo) multipotent precursors, a substantial loss of CD133(hi)CD24(lo) multipotent precursors, and a failure of remaining CD133(hi)CD24(lo) cells to generate glia.	Oxygen	47-53	prominin 1	Mus musculus	148-153
17556599-5	2007	Clonal analysis revealed that apoptosis in 20% oxygen was due to a complete loss of CD133(lo)CD24(lo) multipotent precursors, a substantial loss of CD133(hi)CD24(lo) multipotent precursors, and a failure of remaining CD133(hi)CD24(lo) cells to generate glia.	Oxygen	47-53	prominin 1	Mus musculus	148-153
2394729-2	1990	Ascorbate-reduced dopamine beta-hydroxylase (DBH) is inhibited by CO in a competitive manner with respect to molecular O2.	Oxygen	119-121	dopamine beta-hydroxylase	Homo sapiens	45-48
2164357-2	1990	EPR signals of Mn(II) in the GDP complex with viral-Harvey p21pRAS1 (Arg 12, Thr 59), p21EC (Gly 12, Thr 59), and p21EJ (Val 12, Thr 59) have narrow line-widths that permit ready observation of inhomogeneous broadening from unresolved superhyperfine coupling with the nuclear spin of 17O of directly coordinated oxygen ligands.	Oxygen	312-318	H3 histone pseudogene 16	Homo sapiens	59-67
17560742-1	2007	Cytoglobin (Cygb), a recently discovered vertebrate cytoplasmic heme-binding globin, is considered to be in a clade with vertebrate myoglobin (Mb), which is exclusively distributed in the cytoplasm of cardiac and skeletal muscles as an oxygen storage protein.	Oxygen	236-242	cytoglobin S homeolog	Xenopus laevis	0-10
17560742-1	2007	Cytoglobin (Cygb), a recently discovered vertebrate cytoplasmic heme-binding globin, is considered to be in a clade with vertebrate myoglobin (Mb), which is exclusively distributed in the cytoplasm of cardiac and skeletal muscles as an oxygen storage protein.	Oxygen	236-242	cytoglobin S homeolog	Xenopus laevis	12-16
17560742-13	2007	Considering the absence of mb in the Anura, we hypothesize that Cygb in muscle cells of anurans compensates for the lack of Mb for the storage and intracellular transportation of oxygen.	Oxygen	179-185	cytoglobin S homeolog	Xenopus laevis	64-68
2230398-3	1990	The right heart catheterization revealed the step-up of oxygen saturation in distal part of left pulmonary artery A10.	Oxygen	56-62	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	114-117
17652159-7	2007	Some motor, centrosome and kinetochore proteins (dynein, Kin-8, Cnn, TACC, Cenp-C, Nuf2) are rapidly relocalized after oxygen deprivation.	Oxygen	119-125	centrosomin	Drosophila melanogaster	64-67
17652159-7	2007	Some motor, centrosome and kinetochore proteins (dynein, Kin-8, Cnn, TACC, Cenp-C, Nuf2) are rapidly relocalized after oxygen deprivation.	Oxygen	119-125	Centromeric protein-C	Drosophila melanogaster	75-81
17652159-7	2007	Some motor, centrosome and kinetochore proteins (dynein, Kin-8, Cnn, TACC, Cenp-C, Nuf2) are rapidly relocalized after oxygen deprivation.	Oxygen	119-125	Nuf2	Drosophila melanogaster	83-87
2198533-6	1990	The concentration of CAT and xylE gene products in cells grown under 5% oxygen was 5-7 times that of aerobically (20% oxygen) grown cells.	Oxygen	72-78	chloramphenicol acetyltransferase	Escherichia coli	21-24
17646578-1	2007	BACKGROUND: Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF)-alpha subunits.	Oxygen	94-100	egl-9 family hypoxia-inducible factor 2	Mus musculus	64-68
2198533-6	1990	The concentration of CAT and xylE gene products in cells grown under 5% oxygen was 5-7 times that of aerobically (20% oxygen) grown cells.	Oxygen	118-124	chloramphenicol acetyltransferase	Escherichia coli	21-24
17558023-2	2007	The HIF-1alpha subunit is subjected to O(2)-dependent prolyl hydroxylation leading to ubiquitination by the von Hippel-Lindau protein (VHL)-Elongin C ubiquitin-ligase complex and degradation by the 26 S proteasome.	Oxygen	39-43	elongin C	Homo sapiens	140-149
17442734-2	2007	In the disk, nucleus pulposus cells express hypoxia-inducible factor (HIF)-1alpha, a transcription factor that responds to oxygen tension and regulates glycolysis.	Oxygen	123-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	44-81
17442734-11	2007	Results of this study indicate that oxygen-independent stabilization of HIF-1alpha in nucleus pulposus cells is a metabolic adaptation that drives glycolysis and aggrecan expression.	Oxygen	36-42	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	72-82
2103253-5	1990	It is considered that the first producer factor of the disease is tissular hypoxia secondary to low partial oxygen pressure existing in areas of high sea level.	Oxygen	108-114	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	57-60
17602574-4	2007	In these experiments, CDO exhibits an ordered binding of l-cysteine prior to NO (and presumably O2) similar to that observed for the 2H1C class of non-heme iron enzymes.	Oxygen	96-98	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
17442736-5	2007	Reductions in oxygen tension resulted in dose-dependent increases in GLUT1 and GLUT3 expression.	Oxygen	14-20	solute carrier family 2 member 1	Homo sapiens	69-74
17442736-5	2007	Reductions in oxygen tension resulted in dose-dependent increases in GLUT1 and GLUT3 expression.	Oxygen	14-20	solute carrier family 2 member 3	Homo sapiens	79-84
2383630-0	1990	Reactions of excited triplet states of metal substituted myoglobin with dioxygen and quinone.	Oxygen	72-80	myoglobin	Homo sapiens	57-66
17442736-10	2007	Our results show that GLUTs are upregulated by hypoxia via a HIF-1-mediated pathway in trophoblast cells and suggest that the GLUT response to hypoxia in vivo will be determined not only by low oxygen tension but also by other factors that modulate HIF-1 levels.	Oxygen	194-200	solute carrier family 2 member 1	Homo sapiens	22-26
2344299-7	1990	Twenty-four hours after a single OO/chol meal was fed to chow-fed rabbits, LPL doubled; one CNO/chol meal was associated with only a 40% increase.	Oxygen	33-35	lipoprotein lipase	Oryctolagus cuniculus	75-78
17416738-5	2007	We propose that extrapulmonary, neurogenic events predominate in the pathogenesis of acute pulmonary oxygen toxicity in hyperbaric oxygenation, as nNOS activity drives lung injury by modulating the output of central autonomic pathways.	Oxygen	101-107	nitric oxide synthase 1	Rattus norvegicus	147-151
17607360-1	2007	Erythrocyte precursors produce abundant alpha- and beta-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier.	Oxygen	148-154	hemoglobin beta chain complex	Mus musculus	51-62
2140966-8	1990	At the altitude of Mt Everest, maximal oxygen uptake is reduced to 20-25% of its sea level value, and it is exquisitely sensitive to barometric pressure.	Oxygen	39-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	81-84
17519806-6	2007	Expressions of IL-1beta, IL-12p40, TLR-2, and TLR-4 were increased in cortex/subcortex after resuscitation with 100% O2 compared with 21% O2 (all p &lt; 0.05) and to controls (all p &lt; 0.05).	Oxygen	117-119	interleukin-1 beta	Ovis aries	15-23
17519806-6	2007	Expressions of IL-1beta, IL-12p40, TLR-2, and TLR-4 were increased in cortex/subcortex after resuscitation with 100% O2 compared with 21% O2 (all p &lt; 0.05) and to controls (all p &lt; 0.05).	Oxygen	117-119	toll-like receptor 4	Ovis aries	46-51
2328774-1	1990	We have investigated the expression of the H1 histone subtype H1(0) gene in Ehrlich ascites tumor cells (EAT) under varied conditions of oxygen supply.	Oxygen	137-143	histocompatibility 10	Mus musculus	62-67
17384064-6	2007	On the other hand, when the electrostatic interaction brings the positively charged groups of K-8 and K-28 into the vicinity of the carbonyl oxygen atoms of the inner leaflet lipids, the system exhibits a deep binding mode.	Oxygen	141-147	keratin 8	Homo sapiens	94-97
16506768-4	2006	Use of PCy(3) or P[(4-MeO)C(6)H(4)](3) as the ligand for Pd leads to syn-addition of the arene and the oxygen atom across the double bond, whereas use of (+/-)-BINAP or DPP-benzene affords products that result from anti-addition.	Oxygen	103-109	synemin	Homo sapiens	69-72
2163431-8	1990	In the hippocampus area CA1 increases in [Ca2+]i to as much as 6-8 x 10(-4) were observed; some of these could be reversed when O2 or blood flow were restored to normal.	Oxygen	128-130	carbonic anhydrase 1	Rattus norvegicus	24-27
16272459-3	2006	To test this, we characterized the expression of noncanonical beta-catenin pathway proteins E-cadherin, integrin-linked kinase-1, and beta-catenin in mice undergoing normoxic recovery after exposure to butylated hydroxytoluene (BHT, ionol) and concomitant sublethal (75% O2) hyperoxia.	Oxygen	271-273	catenin (cadherin associated protein), beta 1	Mus musculus	62-74
17538733-2	2007	The most likely reaction pathway for CO oxidation on Rh(111) involves probably migration of atomic oxygen from fcc to hcp sites.	Oxygen	99-105	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	118-121
2181162-1	1990	Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm.	Oxygen	11-17	ATM serine/threonine kinase	Homo sapiens	106-109
17341685-9	2007	Our results indicate that apelin gene is regulated by hypoxia in cardiac myocytes via the HIF pathway, suggesting a role for apelin as a potential marker for acute cardiac hypoxia with a possible compensatory role in myocardial tissue suffering from oxygen deprivation.	Oxygen	250-256	apelin	Rattus norvegicus	26-32
17512557-8	2007	Consequently, dissolved oxygen near the bottom was low in summer, but only occasionally dipped to 2 mgL(-1) despite the high organic loading from sewage effluent.	Oxygen	24-30	LLGL scribble cell polarity complex component 1	Homo sapiens	100-106
16430853-4	2006	Using GOx as a model enzyme, the assembled multilayer membranes showed some striking features such as the adsorbed form of GOx on individual MWCNT, uniformity, good stability, and electrocatalytic activity toward oxygen reduction.	Oxygen	213-219	hydroxyacid oxidase 1	Homo sapiens	6-9
16430853-4	2006	Using GOx as a model enzyme, the assembled multilayer membranes showed some striking features such as the adsorbed form of GOx on individual MWCNT, uniformity, good stability, and electrocatalytic activity toward oxygen reduction.	Oxygen	213-219	hydroxyacid oxidase 1	Homo sapiens	123-126
16430853-5	2006	Based on the consumption of dissolved oxygen during the oxidation process of glucose catalyzed by the immobilized GOx, a sensitive amperometric biosensor was developed for the detection of glucose up to 5.0 mM with a detection limit of 58 microM.	Oxygen	38-44	hydroxyacid oxidase 1	Homo sapiens	114-117
2181162-1	1990	Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm.	Oxygen	67-73	ATM serine/threonine kinase	Homo sapiens	106-109
2315505-0	1990	Oxygen free radical involvement in urinary Tamm-Horsfall protein excretion after intrarenal injection of contrast medium.	Oxygen	0-6	uromodulin	Canis lupus familiaris	43-64
16633015-5	2006	METHOD: Six healthy young adults performed the hand imitation, fist-scissors-gun, and piano key tasks during blood oxygen level-dependent functional magnetic resonance imaging at 3 T. RESULTS: All 3 tasks revealed activation of both premotor and parietal cortices.	Oxygen	115-121	paired box 5	Homo sapiens	193-198
17487275-3	2007	Germ line mutations in the SDHB, SDHC or SDHD genes cause hereditary paraganglioma (PGL) tumors which show constitutive activation of homeostatic mechanisms induced by oxygen deprivation (hypoxia).	Oxygen	168-174	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	27-31
17487275-3	2007	Germ line mutations in the SDHB, SDHC or SDHD genes cause hereditary paraganglioma (PGL) tumors which show constitutive activation of homeostatic mechanisms induced by oxygen deprivation (hypoxia).	Oxygen	168-174	succinate dehydrogenase complex subunit C	Homo sapiens	33-37
17476338-0	2007	Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo.	Oxygen	56-62	C-X3-C motif chemokine receptor 1	Homo sapiens	93-99
17476338-0	2007	Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo.	Oxygen	56-62	C-X-C motif chemokine receptor 4	Homo sapiens	104-109
17476338-4	2007	Short-term exposure of MSCs to 1% oxygen increased expression of the chemokine receptors CX3CR1and CXCR4, both as mRNA and as protein.	Oxygen	34-40	C-X3-C motif chemokine receptor 1	Homo sapiens	89-95
17476338-4	2007	Short-term exposure of MSCs to 1% oxygen increased expression of the chemokine receptors CX3CR1and CXCR4, both as mRNA and as protein.	Oxygen	34-40	C-X-C motif chemokine receptor 4	Homo sapiens	99-104
16677483-9	2006	Compared with the hypoxia group, the mPAP, the plasma levels of U-II, NO, and CNP, and the lung tissue homogenate levels of U-II and CNP in the oxygen treatment group [(31.4 +/- 2.0) mm Hg, (2.1 +/- 0.7) pg/ml, (14.8 +/- 1.7) micromol/L, (4.4 +/- 0.7) pg/ml; (3.5 +/- 0.8) pg/ml, (0.74 +/- 0.17) pg/ml, respectively] were significantly decreased (all P &lt; 0.01).	Oxygen	144-150	natriuretic peptide C	Rattus norvegicus	133-136
16361261-6	2006	In hypothyroidism, nNOS translocation resulted in enhanced mitochondrial nitric-oxide synthase activity with low O2 uptake.	Oxygen	113-115	nitric oxide synthase 1	Rattus norvegicus	19-23
2335199-2	1990	The 17O chemical shifts of the Gly-2 and Gly-3 oxygens of a fully protected Leu-enkephalin were measured to be identical in acetone solution.	Oxygen	47-54	prodynorphin	Homo sapiens	76-90
16462602-3	2006	Gel shift assay showed strong hypoxia-inducible factor-1-DNA binding to only a single site within this cluster, and promoter deletion analysis indicated the functional importance of this chromatin domain in conveying oxygen sensitivity to cytosolic phospholipase A2 gene transcription.	Oxygen	217-223	phospholipase A2 group IVA	Homo sapiens	239-265
17151062-1	2007	BACKGROUND: Neuroglobin is a neurone specific respiratory protein that reversibly binds oxygen.	Oxygen	88-94	neuroglobin	Homo sapiens	12-23
17151062-8	2007	CONCLUSION: Neuroglobin is found in those layers of the human retina that are rich in mitochondria and/or synapses, and consume the highest amount of oxygen.	Oxygen	150-156	neuroglobin	Homo sapiens	12-23
17151062-9	2007	Neuroglobin may be involved in oxygen supply to mitochondria, or in protection from oxidative stress or apoptosis.	Oxygen	31-37	neuroglobin	Homo sapiens	0-11
16473674-5	2006	We would submit that PHD3 variants generated by alternative splicing may be intrinsically involved in the complex system of oxygen sensing.	Oxygen	124-130	egl-9 family hypoxia inducible factor 3	Homo sapiens	21-25
2327213-6	1990	Our observations support the concept that IGF-I rather than erythropoietin modulates erythropoiesis during accelerated growth and thus manages a proportional increase in body mass and oxygen transport capacity.	Oxygen	184-190	insulin-like growth factor 1	Rattus norvegicus	42-47
16483933-8	2006	Together, eIF2alpha, eEF2, and mTOR inhibition represent important HIF-independent mechanisms of energy conservation that promote survival under low O2 conditions.	Oxygen	149-151	eukaryotic translation initiation factor 2A	Homo sapiens	10-19
17385072-4	2007	Neuroglobin shows internal heme hexacoordination, which controls oxygen affinity and kinetics.	Oxygen	65-71	neuroglobin	Homo sapiens	0-11
17385072-5	2007	Neuroglobin concentration, oxygen affinity and enhanced autooxidation question a role in oxygen delivery; thus it was proposed that the neuroprotective effect might be due to radical scavenging or activation of protection mechanisms.	Oxygen	89-95	neuroglobin	Homo sapiens	0-11
2334712-16	1990	The influence of L35 and L345 and that of organic phosphates on the oxygen affinity are additive, but they compete with chloride.	Oxygen	68-74	ribosomal protein L35	Homo sapiens	17-20
16122735-0	2006	Proteins with an endostatin-like domain in a mouse model of oxygen-induced retinopathy.	Oxygen	60-66	collagen, type XVIII, alpha 1	Mus musculus	17-27
2261522-1	1990	Investigations of Myoglobin, Hemoglobin and, more recently of Hemerythrin, suggest that the inward and outward motion of the oxygen ligand is governed by fluctuations between open and closed paths in the protein and that the driving force is the local brownian motion of protein residues.	Oxygen	125-131	myoglobin	Homo sapiens	18-27
16409552-0	2006	Hyperbaric oxygen therapy reduces neuroinflammation and expression of matrix metalloproteinase-9 in the rat model of traumatic brain injury.	Oxygen	11-17	matrix metallopeptidase 9	Rattus norvegicus	70-96
16439573-2	2006	The present study determined the expression of Kvbeta1 and four oxygen-sensitive Kvalpha subunits (Kv1.2, Kv1.5, Kv2.1, and Kv9.3) in the ductus arteriosus (DA), the aorta (Ao), and the pulmonary artery (PA) in porcine neonates immediately after birth.	Oxygen	64-70	potassium voltage-gated channel subfamily B member 1	Homo sapiens	113-118
16439573-2	2006	The present study determined the expression of Kvbeta1 and four oxygen-sensitive Kvalpha subunits (Kv1.2, Kv1.5, Kv2.1, and Kv9.3) in the ductus arteriosus (DA), the aorta (Ao), and the pulmonary artery (PA) in porcine neonates immediately after birth.	Oxygen	64-70	potassium voltage-gated channel modifier subfamily S member 3	Homo sapiens	124-129
16439576-9	2006	We measured increased annexin V binding in isolated primary fetal lung mesenchymal cells cultured in 95% oxygen suggesting a direct effect on cells within the mesenchyme.	Oxygen	105-111	annexin A5	Mus musculus	22-31
16406060-0	2006	Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression.	Oxygen	0-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	52-58
16406060-9	2006	The O2 tension (but not 2-Me addition) in vitro significantly influences overall DC subset frequencies and yield, and governs DC maturation by regulating the surface class II MHC expression of GM-CSF expanded BMDC cultures.	Oxygen	4-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	193-199
16411679-4	2006	The Mo site of sulfite oxidase has two oxygen and three Mo-S ligands (two from cofactor dithiolene plus a cysteine).	Oxygen	39-45	sulfite oxidase	Homo sapiens	15-30
16411186-12	2006	O hydrogen bond with the carbonyl oxygen of the Boc group.	Oxygen	34-40	BOC cell adhesion associated, oncogene regulated	Homo sapiens	48-51
16160860-1	2006	Rat quiescin/sulphydryl oxidase (rQSOX) introduces disulphide bridges into peptides and proteins with the reduction of molecular oxygen to hydrogen peroxide.	Oxygen	129-135	quiescin sulfhydryl oxidase 1	Rattus norvegicus	33-38
17032443-2	2006	However, AVP infusion may be associated with a marked decrease in systemic blood flow and oxygen transport.	Oxygen	90-96	vasopressin-neurophysin 2-copeptin	Ovis aries	9-12
17032443-8	2006	RESULTS: AVP infusion increased mean arterial pressure (MAP) and systemic vascular resistance index at the expense of a markedly decreased CI (4.1 +/- 0.5 versus 8.2 +/- 0.3 l min-1 m-2), DO2I (577 +/- 68 versus 1,150 +/- 50 ml min-1 m-2) and mixed-venous oxygen saturation (SvO2; 54.5 +/- 1.8% versus 69.4 +/- 1.0%; all p &lt; 0.001 versus control).	Oxygen	256-262	vasopressin-neurophysin 2-copeptin	Ovis aries	9-12
17032443-10	2006	CONCLUSION: This study provides evidence that dobutamine is a useful agent for reversing the AVP-associated impairment in systemic blood flow and global oxygen transport.	Oxygen	153-159	vasopressin-neurophysin 2-copeptin	Ovis aries	93-96
16198337-3	2006	The purpose of this study is to determine the effect of endostatin, a potent anti-angiogenic factor, on gene expression of vascular endothelial growth factor (VEGF) and integrinbeta3 in a mouse model of oxygen-induced retinopathy.	Oxygen	203-209	collagen, type XVIII, alpha 1	Mus musculus	56-66
16198337-3	2006	The purpose of this study is to determine the effect of endostatin, a potent anti-angiogenic factor, on gene expression of vascular endothelial growth factor (VEGF) and integrinbeta3 in a mouse model of oxygen-induced retinopathy.	Oxygen	203-209	vascular endothelial growth factor A	Mus musculus	123-157
16198337-3	2006	The purpose of this study is to determine the effect of endostatin, a potent anti-angiogenic factor, on gene expression of vascular endothelial growth factor (VEGF) and integrinbeta3 in a mouse model of oxygen-induced retinopathy.	Oxygen	203-209	vascular endothelial growth factor A	Mus musculus	159-163
16198337-3	2006	The purpose of this study is to determine the effect of endostatin, a potent anti-angiogenic factor, on gene expression of vascular endothelial growth factor (VEGF) and integrinbeta3 in a mouse model of oxygen-induced retinopathy.	Oxygen	203-209	integrin beta 3	Mus musculus	169-182
16421668-5	2006	The arterial partial pressure of oxygen (Pa(O2)) values after the application of HFJV or CPAP increased significantly, from 173.8 +/- 39.6 mmHg (T2) to 344.1 +/- 87.9 mmHg (T3) and 359.9 +/- 82.4 mmHg (T4) in the HFJV group (P &lt; 0.05), and from 153 +/- 38.5 mmHg (T2) to 243 +/- 48.5 mmHg (T3) and 249.7 +/- 55.0 mmHg (T4) in the CPAP group (P &lt; 0.05).	Oxygen	33-39	centromere protein J	Homo sapiens	89-93
16421668-7	2006	The arterial saturation of oxygen (Sa(O) (2)) increased significantly after the application of either HFJV or CPAP (P &lt; 0.05).	Oxygen	27-33	centromere protein J	Homo sapiens	110-114
17072703-1	2006	The transcutaneous measurement of oxygen (tcP(O2)) and carbon dioxide (tcP(CO2)) tensions may serve as a surrogate of arterial oxygen (Pa(O2)) and carbon dioxide (Pa(CO2)) tensions, respectively.	Oxygen	34-40	immunoglobulin kappa variable 1D-39	Homo sapiens	42-48
16385070-1	2006	The hemF gene of Rhodobacter sphaeroides 2.4.1 is predicted to code for an oxygen-dependent coproporphyrinogen III oxidase.	Oxygen	75-81	oxygen-dependent coproporphyrinogen oxidase	Rhodobacter sphaeroides 2.4.1	4-8
16385070-3	2006	We also determined that hemF expression is controlled by oxygen, which is mediated, at least in part, by the response regulatory protein PrrA.	Oxygen	57-63	oxygen-dependent coproporphyrinogen oxidase	Rhodobacter sphaeroides 2.4.1	24-28
16385070-3	2006	We also determined that hemF expression is controlled by oxygen, which is mediated, at least in part, by the response regulatory protein PrrA.	Oxygen	57-63	global response regulator transcription factor PrrA	Rhodobacter sphaeroides 2.4.1	137-141
16939095-2	2006	Moreover, BWKW was post-treated for nitrogen removal in an intermittently aerated moving bed biofilm reactor (MBBR) at 20 degrees C. Removal of total chemical oxygen demand (COD1) was efficient at minimum 90% with all three UASBst at all temperatures.	Oxygen	159-165	retinitis pigmentosa GTPase regulator	Homo sapiens	174-178
16257962-3	2005	We show in O2-sensitive excitable rat PC12 cells that, among the mtDNA-encoded genes, hypoxia produced a specific down-regulation of the transcripts encoding mitochondrial complex I NADH dehydrogenase (ND) subunits, particularly ND4 and ND5 mRNAs and a stable mRNA precursor containing the ND5 and cytochrome b genes.	Oxygen	11-13	NADH dehydrogenase 5, mitochondrial	Rattus norvegicus	237-240
16257962-3	2005	We show in O2-sensitive excitable rat PC12 cells that, among the mtDNA-encoded genes, hypoxia produced a specific down-regulation of the transcripts encoding mitochondrial complex I NADH dehydrogenase (ND) subunits, particularly ND4 and ND5 mRNAs and a stable mRNA precursor containing the ND5 and cytochrome b genes.	Oxygen	11-13	NADH dehydrogenase 5, mitochondrial	Rattus norvegicus	290-293
16257962-3	2005	We show in O2-sensitive excitable rat PC12 cells that, among the mtDNA-encoded genes, hypoxia produced a specific down-regulation of the transcripts encoding mitochondrial complex I NADH dehydrogenase (ND) subunits, particularly ND4 and ND5 mRNAs and a stable mRNA precursor containing the ND5 and cytochrome b genes.	Oxygen	11-13	cytochrome b, mitochondrial	Rattus norvegicus	298-310
16321790-6	2005	These various responses might be based on a range of oxygen sensing signal cascades including an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial chain such as a specialized mitochondrial, low PO2 affinity cytochrome c oxidase (aa3) and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl-hydroxylase and HIF asparaginyl hydroxylase called factor-inhibiting HIF (FIH-1).	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	455-460
16396835-8	2005	All together, our data suggest that PTB plays a stimulatory role in the IRES-mediated translation of HIF-1alpha when oxygen supply is limited.	Oxygen	117-123	polypyrimidine tract binding protein 1	Homo sapiens	36-39
16151053-3	2005	In lung epithelial-derived A549 cells, which are known to die by necrosis when exposed to oxygen, a minimal amount of PARP-1 was cleaved, correlating with the absence of active caspase-3.	Oxygen	90-96	poly (ADP-ribose) polymerase family, member 1	Mus musculus	118-124
16533928-2	2005	Initiating insults, such as elevated or depressed temperature, diminished oxygen, and pressure, increase HSP expression and can protect cells against subsequent, otherwise lethal, insults.	Oxygen	74-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	105-108
16343079-10	2005	CONCLUSIONS: The results provide evidences that oxidative stress and nitric oxide-derived reactive oxygen intermediates induce specific alterations in protein expression that may be critical for the induction of apoptosis and necrosis by d-GalN in cultured human hepatocytes.	Oxygen	99-105	galanin and GMAP prepropeptide	Homo sapiens	240-244
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	CREB binding protein	Mus musculus	180-200
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	CREB binding protein	Mus musculus	202-205
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	E1A binding protein p300	Mus musculus	211-215
16274228-2	2005	It catalyzes a reaction in two parts: (1) reduction of the FAD in the enzyme by NADPH in response to binding of p-hydroxybenzoate to the enzyme and (2) oxidation of reduced FAD with oxygen in an environment free from solvent to form a hydroperoxide, which then reacts with p-hydroxybenzoate to form an oxygenated product.	Oxygen	182-188	2,4-dienoyl-CoA reductase 1	Homo sapiens	80-85
17456219-6	2007	RESULTS: NAC (0.1-1 mm) inhibited the extracellular generation of oxygen species induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and eotaxin (in the presence of IL-5) with -logIC(50) values of 3.61+/-0.03 and 3.36+/-0.09, respectively.	Oxygen	66-72	X-linked Kx blood group	Homo sapiens	9-12
17672171-9	2007	CONCLUSIONS: Three main gender differences are observed in tissue gas loading and unloading under hyperbaric oxygen exposures: Females release SC N2 more slowly and saturate MM O2 and SC O2 to greater extents.	Oxygen	109-115	growth factor independent 1 transcriptional repressor	Homo sapiens	143-148
17381072-4	2007	The amino terminal of the beta-chain of HbA is modified by 2-hydroxy, 3-phospho propylation first to generate a low oxygen affinity Hb, HPPr-HbA.	Oxygen	116-122	sodium voltage-gated channel alpha subunit 2	Homo sapiens	40-43
17381072-4	2007	The amino terminal of the beta-chain of HbA is modified by 2-hydroxy, 3-phospho propylation first to generate a low oxygen affinity Hb, HPPr-HbA.	Oxygen	116-122	sodium voltage-gated channel alpha subunit 2	Homo sapiens	141-144
17381072-7	2007	To further modulate the oxygen affinity of Hb, the alpha alpha-fumaryl cross-bridge has been introduced into HPPr-HbA in the mid central cavity.	Oxygen	24-30	sodium voltage-gated channel alpha subunit 2	Homo sapiens	114-117
17381072-8	2007	The doubly modified HbA (alpha alpha-fumaryl-HPPr-HbA) exhibits an O2 affinity lower than that of either of the singly modified Hbs, with a partial additivity of the two modifications.	Oxygen	67-69	sodium voltage-gated channel alpha subunit 2	Homo sapiens	20-23
17381072-8	2007	The doubly modified HbA (alpha alpha-fumaryl-HPPr-HbA) exhibits an O2 affinity lower than that of either of the singly modified Hbs, with a partial additivity of the two modifications.	Oxygen	67-69	sodium voltage-gated channel alpha subunit 2	Homo sapiens	31-53
17259268-0	2007	A highly sensitive biocompatible spin probe for imaging of oxygen concentration in tissues.	Oxygen	59-65	spindlin 1	Mus musculus	33-37
17315910-0	2007	Nitric oxide and oxygen radical attack on GDP-dissociation inhibitor 2 (GDI-2) in spinal cord injury of the rat.	Oxygen	17-23	GDP dissociation inhibitor 2	Rattus norvegicus	42-70
17315910-0	2007	Nitric oxide and oxygen radical attack on GDP-dissociation inhibitor 2 (GDI-2) in spinal cord injury of the rat.	Oxygen	17-23	GDP dissociation inhibitor 2	Rattus norvegicus	72-77
17386751-3	2007	This immobilized uricase membrane permits the permeation of oxygen, which is consumed by the uricase reaction.	Oxygen	60-66	urate oxidase (pseudogene)	Homo sapiens	17-24
17386751-3	2007	This immobilized uricase membrane permits the permeation of oxygen, which is consumed by the uricase reaction.	Oxygen	60-66	urate oxidase (pseudogene)	Homo sapiens	93-100
17082319-6	2007	Improved flap survival correlated with increased recovery of oxygen levels in the ischemic tissue of thrombospondin-1-null mice as measured by electron paramagnetic resonance oximetry.	Oxygen	61-67	thrombospondin 1	Mus musculus	101-117
17322643-0	2007	Hyperbaric oxygen induces basic fibroblast growth factor and hepatocyte growth factor expression, and enhances blood perfusion and muscle regeneration in mouse ischemic hind limbs.	Oxygen	11-17	hepatocyte growth factor	Mus musculus	61-85
17349848-1	2007	BACKGROUND: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme that scavenges superoxide radicals found in the mitochondria, has been shown to protect oxygen-utilizing cells from the toxicity of the reactive oxygen species (ROS).	Oxygen	171-177	superoxide dismutase 2	Rattus norvegicus	12-42
17349848-1	2007	BACKGROUND: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme that scavenges superoxide radicals found in the mitochondria, has been shown to protect oxygen-utilizing cells from the toxicity of the reactive oxygen species (ROS).	Oxygen	171-177	superoxide dismutase 2	Rattus norvegicus	44-49
16986127-2	2007	Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III), with a free energy capable of producing water from oxygen.	Oxygen	162-168	hemoglobin subunit gamma 2	Homo sapiens	54-67
17969555-15	2007	Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-.	Oxygen	192-198	mitochondrially encoded cytochrome b	Homo sapiens	23-35
24557617-4	2007	The activities of 6HRE-GFAP-promoter increased by 3.08 and 1.30-fold under 2% O2 condition compared with those under 18% O2 condition, while under 0.2% O2 condition increased by 8.90 and 2.69-fold, respectively.	Oxygen	78-80	glial fibrillary acidic protein	Homo sapiens	23-27
24557617-4	2007	The activities of 6HRE-GFAP-promoter increased by 3.08 and 1.30-fold under 2% O2 condition compared with those under 18% O2 condition, while under 0.2% O2 condition increased by 8.90 and 2.69-fold, respectively.	Oxygen	121-123	glial fibrillary acidic protein	Homo sapiens	23-27
24557617-4	2007	The activities of 6HRE-GFAP-promoter increased by 3.08 and 1.30-fold under 2% O2 condition compared with those under 18% O2 condition, while under 0.2% O2 condition increased by 8.90 and 2.69-fold, respectively.	Oxygen	121-123	glial fibrillary acidic protein	Homo sapiens	23-27
17082363-4	2007	The AMP-activated protein kinase, hypoxia-inducible factor 1, peroxisome proliferator-activated receptors, and Sirt1 proteins all contribute to altering skeletal muscle gene expression by sensing changes in the concentrations of AMP, molecular oxygen, intracellular free fatty acids, and NAD+, respectively.	Oxygen	244-250	sirtuin 1	Homo sapiens	111-116
17132813-6	2007	VEGF secretion was increased 1.9 +/- 0.04-fold with NECA (10 microM) and 1.7 +/- 0.1-fold with hypoxia (5% O(2)) but 3.8 +/- 0.1-fold when these two stimuli were combined.	Oxygen	107-112	vascular endothelial growth factor A	Mus musculus	0-4
19071278-3	2007	The electrode showed a sensitive current response to the reduction of the o-quinone, which was the oxidation product of phenol, by the tyrosinase, in the presence of oxygen.	Oxygen	166-172	tyrosinase	Homo sapiens	135-145
17175208-9	2007	The sulfonated cysteines have two sulfite oxygens involved in intramonomer hydrogen bonds that bridge Cys10, the amino acid immediately before beta-strand A, to the amino acids immediately after the edge beta-strand D. Implications of the newly observed interactions in the inhibition of fibril formation are discussed in light of the recent structural models of TTR amyloid fibrils.	Oxygen	42-49	transthyretin	Homo sapiens	363-366
17913148-3	2007	After 7 d, almost all MTBE was degraded by a pure culture, a member of beta-Proteobacteria named as PM1, in a closed system with oxygen supply, while only 40% MTBE was degraded in one without oxygen supply.	Oxygen	129-135	transmembrane protein 11	Homo sapiens	100-103
17913161-2	2007	Total organic carbon (TOC) and chemical oxygen demand (COD(Cr)) assays show that the degradation rate of SRB is much higher when irradiated with UV and sunlight compared with visible light.	Oxygen	40-46	chaperonin containing TCP1 subunit 4	Homo sapiens	105-108
17998049-12	2007	Together, these methods are rapid and well suited to the preliminary characterization of potential substrates of the therapeutically relevant oxygen-sensing enzyme FIH-1.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	164-169
17998050-2	2007	Under normal oxygen tensions, the pathway is negatively regulated by posttranslational proteasomal degradation of HIF-alpha (alpha) subunits in a pathway requiring prolyl-hydroxylase domain (PHD) containing enzyme modification followed by von-Hippel Lindau (VHL) tumor suppressor polyubiquitination (pVHL).	Oxygen	13-19	von Hippel-Lindau tumor suppressor	Mus musculus	300-304
18058544-3	2007	In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.	Oxygen	117-123	O-6-methylguanine-DNA methyltransferase	Homo sapiens	60-100
18058544-3	2007	In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.	Oxygen	117-123	O-6-methylguanine-DNA methyltransferase	Homo sapiens	102-106
18605250-3	2007	Methemoglobinemia is an abnormal elevation of MHb levels resulting in impaired oxygen delivery to tissues as well as a left shift of the oxygen-Hb dissociation curve.	Oxygen	79-85	hemoglobin subunit gamma 2	Homo sapiens	46-49
17011183-3	2006	Recent advances in the structural biology of O(2)-activating copper enzymes range from the identification of novel copper centers, such as that of particulate methane monooxygenase, to the elucidation of the details of O(2) binding and reactivity in peptidylglycine alpha-hydroxylating monooxygenase.	Oxygen	219-223	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	250-299
17078624-6	2006	For the case of the triplet dioxygen molecule, it was shown that restricted open-shell density functional theory (RODFT), as well as CASSCF, can provide accurate spin-spin couplings while spin-unrestricted DFT leads to much larger errors.	Oxygen	28-36	spindlin 1	Homo sapiens	162-166
17078624-6	2006	For the case of the triplet dioxygen molecule, it was shown that restricted open-shell density functional theory (RODFT), as well as CASSCF, can provide accurate spin-spin couplings while spin-unrestricted DFT leads to much larger errors.	Oxygen	28-36	spindlin 1	Homo sapiens	167-171
17078624-6	2006	For the case of the triplet dioxygen molecule, it was shown that restricted open-shell density functional theory (RODFT), as well as CASSCF, can provide accurate spin-spin couplings while spin-unrestricted DFT leads to much larger errors.	Oxygen	28-36	spindlin 1	Homo sapiens	167-171
17077295-4	2006	Structural studies revealed that neuroglobin has a typical globin fold, and despite being hexacoordinated, it binds reversibly O2, CO, and NO, undergoing a substantial conformational change of the heme and of the protein.	Oxygen	127-129	neuroglobin	Homo sapiens	33-44
17077295-6	2006	Neuroglobin is unlikely to be involved in O2 transport (like myoglobin), although it seems to act as a sensor of the O2/NO ratio in the cell, possibly regulating the GDP/GTP exchange rate forming a specific complex with the G(alpha beta gamma)-protein when oxidized but not when bound to a gaseous ligand.	Oxygen	117-119	neuroglobin	Homo sapiens	0-11
16980385-2	2006	The stability of the C. elegans HIF-1 protein is controlled by the evolutionarily conserved EGL-9/VHL-1 pathway for oxygen-dependent degradation.	Oxygen	116-122	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	92-97
16980394-9	2006	These data suggest that gpd-2 and gpd-3 may serve a protective role in tissue exposed to oxygen deprivation.	Oxygen	89-95	Glyceraldehyde-3-phosphate dehydrogenase 2	Caenorhabditis elegans	24-29
16980394-9	2006	These data suggest that gpd-2 and gpd-3 may serve a protective role in tissue exposed to oxygen deprivation.	Oxygen	89-95	Glyceraldehyde-3-phosphate dehydrogenase 3	Caenorhabditis elegans	34-39
16930622-1	2006	BACKGROUND: We have recently shown that attenuation of sepsis-induced lung injury by hyperbaric oxygen (HBO) pretreatment involves expression regulation of inducible nitric oxide synthase (iNOS) and heme oxygenase (HO)-1.	Oxygen	96-102	heme oxygenase 1	Rattus norvegicus	199-220
17016583-9	2006	Continuous oxygen consumption of these cells monitored by a multi-channel dissolved oxygen meter is 1.70-fold higher in OV 2008 cells than C13 cells and the oxygen consumption was decreased by 30% in C13 cells, suggesting mitochondrial respiratory malfunction in these cells.	Oxygen	11-17	homeobox C13	Homo sapiens	139-142
17033702-1	2006	The finding that dioxygen binds end-on to the Cu(B) site in the crystal structure of a precatalytic complex of peptidylglycine alpha-hydroxylating monooxygenase has spurred the search for biomimetic model complexes exhibiting the same dioxygen coordination.	Oxygen	17-25	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	111-160
17033702-1	2006	The finding that dioxygen binds end-on to the Cu(B) site in the crystal structure of a precatalytic complex of peptidylglycine alpha-hydroxylating monooxygenase has spurred the search for biomimetic model complexes exhibiting the same dioxygen coordination.	Oxygen	235-243	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	111-160
16962712-0	2006	Ectopic expression of doublecortin protects adult rat progenitor cells and human glioma cells from severe oxygen and glucose deprivation.	Oxygen	106-112	doublecortin	Rattus norvegicus	22-34
16962712-3	2006	We tested the hypothesis that DCX, in addition to being a marker of migrating neuroblasts, serves to protect neuroblasts from conditions of stress, such as oxygen and glucose deprivation (OGD).	Oxygen	156-162	doublecortin	Rattus norvegicus	30-33
17042492-2	2006	Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4 equiv of Fe(II) to the reduction of O2 to 2 H2O.	Oxygen	127-129	ferroxidase	Saccharomyces cerevisiae S288C	11-22
16234921-2	2005	Because NOSs are the only hemeproteins known to contain tetrahydrobiopterin (H4B) as a bound cofactor, the function and role of H4B in their heme-based oxygen activation and catalysis is of current interest.	Oxygen	152-158	H4 clustered histone 4	Homo sapiens	128-131
33820854-4	2021	We found that the upregulation of RUNXOR and RUNX1 is associated with the expressions of several key immunosuppressive molecules, including arginase 1, inducible NO synthase, STAT3, IL-6, and reactive oxygen species.	Oxygen	201-207	RUNX family transcription factor 1	Homo sapiens	45-50
16895900-1	2006	The heterodimeric flavocytochrome b558, comprised of the two integral membrane proteins p22phox and gp91phox, mediates the transfer of electrons from NADPH to molecular oxygen in the phagocyte NADPH oxidase to generate the superoxide precursor of microbicidal oxidants.	Oxygen	169-175	cytochrome b-245 beta chain	Homo sapiens	100-108
33940402-4	2021	alpha-MnO2 was found to contain the most abundant oxygen vacancy and readily reducible surface adsorbed oxygen (O2-, O-, OH-), which facilitated an increase of ozone utilization and the highest catalytic performance with 99% degradation efficiency for IBU and MET.	Oxygen	104-110	SAFB like transcription modulator	Homo sapiens	260-263
16966387-9	2006	In axial muscle, expression of the "slow" types of myosin and troponin C was increased, together with expression of erythropoietin and myoglobin, which enhance oxygen transport, indicating a shift toward a slow aerobic phenotype.	Oxygen	160-166	erythropoietin a	Danio rerio	116-130
16421507-7	2006	These results suggest that maintaining penumbral oxygenation by normobaric oxygen treatment during ischemia lead to neuroprotection, which is further reflected by the decreased production of ROS, MMP-9, and caspase-8.	Oxygen	49-55	matrix metallopeptidase 9	Rattus norvegicus	196-201
16421507-7	2006	These results suggest that maintaining penumbral oxygenation by normobaric oxygen treatment during ischemia lead to neuroprotection, which is further reflected by the decreased production of ROS, MMP-9, and caspase-8.	Oxygen	49-55	caspase 8	Rattus norvegicus	207-216
33811560-8	2021	Among KTRs, tau showed a moderate negative correlation with Peak VO2 (rho = - 0.52) and Oxygen uptake efficiency slope (OUES) (r = - 0.57) while no significant correlation with Hb and peak heart rate.	Oxygen	88-94	microtubule associated protein tau	Homo sapiens	12-15
17274530-7	2006	The NDUFS1 mutation, with less severe progressive pathology, caused only partial inhibition of the complex but enhanced production of oxygen free radicals.	Oxygen	134-140	NADH:ubiquinone oxidoreductase core subunit S1	Homo sapiens	4-10
16923892-3	2006	Oxygen reduction rates of the roo and srr mutants were 20 to 40% lower than those of the wild type and the sor mutant, indicating that Roo functions as an O2 reductase in vivo.	Oxygen	0-6	roO	Desulfovibrio vulgaris str. Hildenborough	30-33
16923892-3	2006	Oxygen reduction rates of the roo and srr mutants were 20 to 40% lower than those of the wild type and the sor mutant, indicating that Roo functions as an O2 reductase in vivo.	Oxygen	0-6	roO	Desulfovibrio vulgaris str. Hildenborough	135-138
16923892-5	2006	The similar survival rates of sor mutant and wild-type cells suggest that O2 reduction by Roo prevents the formation of reactive oxygen species (ROS) under these conditions; i.e., the ROS-reducing enzyme Sor is only needed for survival when Roo is missing.	Oxygen	74-76	roO	Desulfovibrio vulgaris str. Hildenborough	90-93
16923892-5	2006	The similar survival rates of sor mutant and wild-type cells suggest that O2 reduction by Roo prevents the formation of reactive oxygen species (ROS) under these conditions; i.e., the ROS-reducing enzyme Sor is only needed for survival when Roo is missing.	Oxygen	74-76	roO	Desulfovibrio vulgaris str. Hildenborough	241-244
16923892-6	2006	In contrast, the sor mutant was inactivated much more rapidly than the roo mutant when liquid cultures were incubated in 100% air, indicating that O2 reduction by Roo and other terminal oxidases did not prevent ROS formation under these conditions.	Oxygen	147-149	roO	Desulfovibrio vulgaris str. Hildenborough	163-166
33818447-1	2021	Hyperbaric oxygen therapy, intermittent breathing of 100% oxygen at a pressure upper than sea level, has been shown to be some of the neuroprotective effects and used therapeutically in a wide range of neurological disorders.	Oxygen	11-17	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
16854431-7	2006	During hypoxia, efg1 mutants contained lower levels of unsaturated fatty acids, while hyphal morphogenesis on solid media was significantly increased at temperatures &lt;37 degrees C. These results suggest that during oxygen-limitation, Efg1p acts as a repressor of filamentation and as a positive regulator of fatty acid desaturation.	Oxygen	218-224	Efg1p	Saccharomyces cerevisiae S288C	16-20
33818447-1	2021	Hyperbaric oxygen therapy, intermittent breathing of 100% oxygen at a pressure upper than sea level, has been shown to be some of the neuroprotective effects and used therapeutically in a wide range of neurological disorders.	Oxygen	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
16885361-0	2006	Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.	Oxygen	67-69	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	12-35
16885361-2	2006	Hamster fibroblasts expressing a mutation in SDH subunit C (SDHC; B9) showed 3-fold increases in dihydroethidine and dichlorodihydrofluorescein (CDCFH(2)) oxidation indicative of increased steady-state levels of O2(.-) and H2O2, increases in glutathione/glutathione disulfide (indicative of oxidative stress), as well as increases in superoxide dismutase activity, relative to parental B1 cells.	Oxygen	212-214	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	45-48
33808703-2	2021	Central to this condition is the role of macrophages that, activated by radiation-induced reactive oxygen species and tissue cell damage, produce pro-inflammatory cytokines, such as transforming growth factor beta (TGFbeta).	Oxygen	99-105	transforming growth factor alpha	Mus musculus	215-222
16885361-2	2006	Hamster fibroblasts expressing a mutation in SDH subunit C (SDHC; B9) showed 3-fold increases in dihydroethidine and dichlorodihydrofluorescein (CDCFH(2)) oxidation indicative of increased steady-state levels of O2(.-) and H2O2, increases in glutathione/glutathione disulfide (indicative of oxidative stress), as well as increases in superoxide dismutase activity, relative to parental B1 cells.	Oxygen	212-214	succinate dehydrogenase complex subunit C	Homo sapiens	60-64
16885361-5	2006	These data show that SDHC mutations cause increased O2(.-) production, metabolic oxidative stress, and genomic instability and that mutations in genes coding for mitochondrial electron transport chain proteins can contribute to phenotypic changes associated with cancer cells.	Oxygen	52-54	succinate dehydrogenase complex subunit C	Homo sapiens	21-25
16763504-0	2006	S100B protein in conscious carbon monoxide-poisoned rats treated with normobaric or hyperbaric oxygen.	Oxygen	95-101	S100 calcium binding protein B	Rattus norvegicus	0-5
33031904-0	2020	Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts.	Oxygen	50-56	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	91-94
16763504-1	2006	OBJECTIVE: To evaluate S100B, an astroglial structural protein, during normobaric and hyperbaric oxygen therapy of conscious carbon monoxide (CO)-poisoned rats.	Oxygen	97-103	S100 calcium binding protein B	Rattus norvegicus	23-28
16763504-12	2006	The post hoc test results showed that S100B levels after therapy of the first group treated with ambient air (0.16 +/- 0.07 microg/L) and the second group treated with normobaric oxygen (0.19 +/- 0.05 microg/L) were similar (p = .741), and both of them were significantly different, with much higher values of S100B levels after therapy, from the third group treated with hyperbaric oxygen (0.06 +/- 0.03 microg/L; p = .018 and p = .002, respectively).	Oxygen	179-185	S100 calcium binding protein B	Rattus norvegicus	38-43
16763504-12	2006	The post hoc test results showed that S100B levels after therapy of the first group treated with ambient air (0.16 +/- 0.07 microg/L) and the second group treated with normobaric oxygen (0.19 +/- 0.05 microg/L) were similar (p = .741), and both of them were significantly different, with much higher values of S100B levels after therapy, from the third group treated with hyperbaric oxygen (0.06 +/- 0.03 microg/L; p = .018 and p = .002, respectively).	Oxygen	383-389	S100 calcium binding protein B	Rattus norvegicus	38-43
16763504-14	2006	CONCLUSIONS: S100B is elevated in conscious CO-poisoned rats left on ambient air or treated with normobaric oxygen, but not in conscious CO-poisoned rats treated with hyperbaric oxygen.	Oxygen	108-114	S100 calcium binding protein B	Rattus norvegicus	13-18
32796124-7	2020	The loss of FAD5 in the crl mutant might attenuate the levels of RES and/or lipid peroxidation due to the reduced levels of palmitic acid-driven PUFAs, which are prime targets of reactive oxygen species.	Oxygen	188-194	fatty acid desaturase 5	Arabidopsis thaliana	12-16
16740253-1	2006	Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF).	Oxygen	29-35	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	359-364
32782788-6	2020	Further analysis indicated that a DRP1 deficiency caused mitochondrial dysfunction and induced oxidative stress, which was confirmed by increased reactive oxygen species levels.	Oxygen	155-161	dynamin 1 like	Homo sapiens	34-38
16763165-1	2006	Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the beta-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts.	Oxygen	73-79	pumilio RNA binding family member 3	Homo sapiens	43-47
16611863-10	2006	EGLN1, EGLN2, and EGLN3 were also temporally expressed in an oxygen-dependent fashion, with greatest mRNA expression at 10-12 wk of gestation.	Oxygen	61-67	egl-9 family hypoxia inducible factor 3	Homo sapiens	18-23
1447747-5	1992	In this paper we report the results of synthetic and metabolic studies on a series of tetrahydropyridine analogs of MPTP with oxygen, sulfur, and carbamoyloxy derivatives on C-4 which serve as model compounds to evaluate the scope of this prodrug concept.	Oxygen	126-132	complement C4A (Rodgers blood group)	Homo sapiens	174-177
16513203-8	2006	The PCNA positive SEC, in contrast, was significantly increased in the hyperbaric oxygen group at 48h, furthermore, the hyperbaric oxygen treatment significantly increased the expression of VEGF protein in the regenerating liver at 24 and 48 h. CONCLUSIONS: Hyperbaric oxygen treatment can be considered as a therapeutic modality after massive PH.	Oxygen	131-137	proliferating cell nuclear antigen	Rattus norvegicus	4-8
16765982-2	2006	Three prolyl hydroxylases (PHD1-3) underlie oxygen-regulated destruction of HIFalpha chains.	Oxygen	44-50	egl-9 family hypoxia-inducible factor 2	Rattus norvegicus	27-31
16765982-8	2006	Overall our results show that PHD2 mRNA is ubiquitously expressed in normal animals, in keeping with a general role in oxygen sensing.	Oxygen	119-125	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	30-34
16765982-13	2006	Inducibility of PHD2 and 3 by hypoxia and ischemia in vivo has important implications both for the pathophysiology of conditions where oxygen supply is deranged and for attempts to manipulate the HIF system therapeutically.	Oxygen	135-141	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	16-26
16846785-11	2006	PAF and U-46619 decreased hepatic oxygen consumption while LTD(4) induced biphasic change of an initial transient decrease followed by an increase.	Oxygen	34-40	PCNA clamp associated factor	Rattus norvegicus	0-3
16259558-0	2005	Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	146-152	vascular endothelial growth factor A	Mus musculus	46-80
16259558-2	2005	In this study, we used a mouse model of oxygen-induced retinopathy (OIR) to explore the potential of gene expression and secretion of short VEGF peptides as a treatment.	Oxygen	40-46	vascular endothelial growth factor A	Mus musculus	140-144
16259558-7	2005	The results demonstrated that exon 6- and 7-derived VEGF peptides effectively inhibited oxygen-induced retinal NV.	Oxygen	88-94	vascular endothelial growth factor A	Mus musculus	52-56
16293774-7	2005	It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule.	Oxygen	83-89	mitochondrially encoded cytochrome b	Homo sapiens	24-36
16244712-1	2005	A commemorative plaque in York Hospital in Pennsylvania, USA, records that George E Holtzapple MD is the physician "who discovered the use of oxygen for the treatment of pneumonia on March 6, 1885".	Oxygen	142-148	membrane associated ring-CH-type finger 6	Homo sapiens	183-190
16909615-0	2006	[Expression and role of endostatin in the retina of oxygen-induced retinopathy mouse model].	Oxygen	52-58	collagen, type XVIII, alpha 1	Mus musculus	24-34
16909615-1	2006	OBJECTIVE: To investigate the effect of endostatin on the pathogenesis and development of retinal neovascula animal model of oxygen-induced retinopathy.	Oxygen	125-131	collagen, type XVIII, alpha 1	Mus musculus	40-50
34799045-3	2022	Importantly, the electrochemical measurements demonstrate that the CTO/CP possesses numerous prominent properties such as lower charge transfer resistance, larger electroactive area, higher oxygen evolution potential than those of the pristine Ti/CoTiO3 (CTO) and Ti/Ce-PbO2 (CP).	Oxygen	190-196	ceruloplasmin	Homo sapiens	67-73
16909615-5	2006	The expression of ES and VEGF in the oxygen-induced retina was observed by immunohistochemistry.	Oxygen	37-43	vascular endothelial growth factor A	Mus musculus	25-29
16771319-3	2006	Solvent-derived adducts, DMPO/*OC2H5 and DMPO/*CH(OH)CH3, were identified, and their presence was rationalized by Fe(III)-catalyzed nucleophilic addition of ethanol to the spin trap and hydrogen abstraction by *OH radicals; oxygen radical adducts, DMPO/*O2(-) and DMPO/*OOH, were also detected.	Oxygen	254-256	spindlin 1	Homo sapiens	172-176
16183084-7	2005	Analyzing L-beta-threo-BA within the context of a novel EAAT2 pharmacophore model suggests: (1) a highly conserved positioning of the electrostatic carboxyl and amino groups; (2) nearby regions that accommodate select structural modifications (cyclopropyl rings, methyl groups, oxygen atoms); and (3) a unique region L-beta-threo-BA occupied by the benzyl moieties of L-TBOA, L-beta-threo-BA and related analogues.	Oxygen	278-284	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	56-61
16853423-3	2005	Successive STM observations revealed transformations among the three configurations, i.e., bridge formate on a 5-fold coordinated Ti4+ row, bridge formate on an oxygen vacancy site with an oxygen atom of formate and on a 5-fold coordinated Ti4+ ion and with the other formate oxygen atom, and a monodentate formate on an oxygen vacancy site with an oxygen atom of formate.	Oxygen	161-167	sulfotransferase family 1A member 3	Homo sapiens	11-14
34953447-11	2022	Of note, MEKK3 over-expression almost abrogated the capacity of TRAF7 knockout to mitigate neuronal death and neuroinflammation in the isolated primary cortical neurons and glial cells upon oxygen-glucose-deprivation/reperfusion (OGD/R) stimulation.	Oxygen	190-196	mitogen-activated protein kinase kinase kinase 3	Mus musculus	9-14
16853423-3	2005	Successive STM observations revealed transformations among the three configurations, i.e., bridge formate on a 5-fold coordinated Ti4+ row, bridge formate on an oxygen vacancy site with an oxygen atom of formate and on a 5-fold coordinated Ti4+ ion and with the other formate oxygen atom, and a monodentate formate on an oxygen vacancy site with an oxygen atom of formate.	Oxygen	189-195	sulfotransferase family 1A member 3	Homo sapiens	11-14
16853423-3	2005	Successive STM observations revealed transformations among the three configurations, i.e., bridge formate on a 5-fold coordinated Ti4+ row, bridge formate on an oxygen vacancy site with an oxygen atom of formate and on a 5-fold coordinated Ti4+ ion and with the other formate oxygen atom, and a monodentate formate on an oxygen vacancy site with an oxygen atom of formate.	Oxygen	189-195	sulfotransferase family 1A member 3	Homo sapiens	11-14
16853423-3	2005	Successive STM observations revealed transformations among the three configurations, i.e., bridge formate on a 5-fold coordinated Ti4+ row, bridge formate on an oxygen vacancy site with an oxygen atom of formate and on a 5-fold coordinated Ti4+ ion and with the other formate oxygen atom, and a monodentate formate on an oxygen vacancy site with an oxygen atom of formate.	Oxygen	189-195	sulfotransferase family 1A member 3	Homo sapiens	11-14
16853423-3	2005	Successive STM observations revealed transformations among the three configurations, i.e., bridge formate on a 5-fold coordinated Ti4+ row, bridge formate on an oxygen vacancy site with an oxygen atom of formate and on a 5-fold coordinated Ti4+ ion and with the other formate oxygen atom, and a monodentate formate on an oxygen vacancy site with an oxygen atom of formate.	Oxygen	189-195	sulfotransferase family 1A member 3	Homo sapiens	11-14
16783171-7	2006	Exposing MV-SMC to hypoxia (1% O2) revealed a different pattern of expression with no significant change in TACE protein, but an increase in TACE mRNA occurring at a later time point (48 hours).	Oxygen	31-33	ADAM metallopeptidase domain 17	Homo sapiens	141-145
16200622-1	2005	OBJECTIVE: To determine whether oxygen-dependent activation patterns of hypoxia-inducible factor 1alpha (HIF-1alpha) observed in vascularized tissues are conserved within avascular and hypoxic articular cartilage and whether HIF-1alpha affects cartilage matrix synthesis.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Bos taurus	72-103
16200622-1	2005	OBJECTIVE: To determine whether oxygen-dependent activation patterns of hypoxia-inducible factor 1alpha (HIF-1alpha) observed in vascularized tissues are conserved within avascular and hypoxic articular cartilage and whether HIF-1alpha affects cartilage matrix synthesis.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Bos taurus	105-115
16200622-1	2005	OBJECTIVE: To determine whether oxygen-dependent activation patterns of hypoxia-inducible factor 1alpha (HIF-1alpha) observed in vascularized tissues are conserved within avascular and hypoxic articular cartilage and whether HIF-1alpha affects cartilage matrix synthesis.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Bos taurus	225-235
16200622-7	2005	Following alteration of the oxygen gradient by removal of the top layers of cartilage, predominantly perinuclear HIF-1alpha was found in the deeper layers.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Bos taurus	113-123
16200622-10	2005	CONCLUSION: These findings demonstrate that hypoxia-dependent activation of HIF-1alpha is highly conserved and that changes in oxygen tensions following cartilage loss from injury or disease alter cartilage metabolism in part by changing HIF-1alpha activity.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Bos taurus	238-248
16780081-10	2006	TAP, smoking and pulmonary hypertension affected long term oxygen supply (P=0.0070, 0.0349 and 0.0355).	Oxygen	59-65	nuclear RNA export factor 1	Homo sapiens	0-3
16633564-4	2006	In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.	Oxygen	115-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	60-98
16633564-4	2006	In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.	Oxygen	115-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	100-104
16426753-2	2006	In the central nervous system (CNS), hippocampal CA1 neurons are known to be extremely vulnerable to low oxygen concentrations or anoxia.	Oxygen	105-111	carbonic anhydrase 1	Homo sapiens	49-52
16426753-5	2006	Specifically, we show that CA1 neurons undergo apoptosis when depleted of oxygen for 12 or 24 h. A KATP channels agonist diazoxide inhibits the observed apoptosis.	Oxygen	74-80	carbonic anhydrase 1	Homo sapiens	27-30
16164960-4	2005	NF-kappaB activation could be inhibited by the active oxygen species scavenger, tetramethylthiourea; the redox-inactive metal chelator, deferoxamine; the Src inhibitor, PP2; and the epidermal growth factor (EGF) receptor inhibitor AG1478.	Oxygen	54-60	epidermal growth factor receptor	Rattus norvegicus	182-220
34625658-11	2022	Moreover, intracellular levels of reactive oxygen species were elevated especially when NCT503 and TMZ treatments were combined, and the synergistic effects could be partially negated by NAC, a classic scavenger of reactive oxygen species.	Oxygen	224-230	synuclein alpha	Homo sapiens	187-190
16086306-0	2005	Fetal oxygen tension promotes tenascin-C-dependent lung branching morphogenesis.	Oxygen	6-12	tenascin C	Rattus norvegicus	30-40
16086306-4	2005	Antisense oligonucleotide studies demonstrated that TN-C produced in response to 3% O(2) was essential for lung branching morphogenesis.	Oxygen	84-88	tenascin C	Rattus norvegicus	52-56
16086306-5	2005	As well, exogenous TN-C protein was shown to promote branching of lung epithelial rudiments cultured at 21% O(2).	Oxygen	108-112	tenascin C	Rattus norvegicus	19-23
16584176-9	2006	These results suggest that ADX functions as an effector for the oxygen transfer reaction in addition to being an electron donor for CYP27B1.	Oxygen	64-70	ferredoxin 1	Homo sapiens	27-30
34695441-5	2022	Blood-oxygen level dependent signal changes were measured as 86 participants performed a Go/NoGo response inhibition task while undergoing functional magnetic resonance imaging (fMRI).	Oxygen	6-12	reticulon 4	Homo sapiens	92-96
16545379-1	2006	Blue fluorescent protein from the calcium-binding photoprotein aequorin (BFP-aq) is a complex of Ca2+ -bound apoaequorin and coelenteramide, and shows luminescence activity like a luciferase, catalyzing the oxidation of coelenterazine with molecular oxygen.	Oxygen	250-256	ring finger protein 112	Homo sapiens	73-76
16086306-6	2005	Because ECM-degrading proteinases are capable of catabolizing TN-C protein, we reasoned that 3% O(2) might promote TN-C deposition by limiting the activity of these enzymes within the fetal lung.	Oxygen	96-100	tenascin C	Rattus norvegicus	62-66
16086306-6	2005	Because ECM-degrading proteinases are capable of catabolizing TN-C protein, we reasoned that 3% O(2) might promote TN-C deposition by limiting the activity of these enzymes within the fetal lung.	Oxygen	96-100	tenascin C	Rattus norvegicus	115-119
16190887-6	2005	Vascular endothelial growth factor (VEGF), a factor regulated by HIF-1, was strongly stimulated in neurons cultured in 1% O2.	Oxygen	122-124	vascular endothelial growth factor A	Mus musculus	0-34
16190887-6	2005	Vascular endothelial growth factor (VEGF), a factor regulated by HIF-1, was strongly stimulated in neurons cultured in 1% O2.	Oxygen	122-124	vascular endothelial growth factor A	Mus musculus	36-40
34962378-5	2022	Benefiting from the above superiorities of morphological and chemical compositions, this self-supported CoP@Fe-CoP/NC/NF heterostructure can drive alkaline hydrogen evolution reaction and oxygen evolution reaction with overpotentials of 97 and 270 mV to yield 100 mA cm-2, respectively.	Oxygen	188-194	caspase recruitment domain family member 16	Homo sapiens	104-107
16190887-7	2005	Treatment of neurons with exogenous VEGF partially improved survival in 20% O2, and inhibitors of VEGF action reduced survival of neurons in 1% O2.	Oxygen	76-78	vascular endothelial growth factor A	Mus musculus	36-40
16190887-7	2005	Treatment of neurons with exogenous VEGF partially improved survival in 20% O2, and inhibitors of VEGF action reduced survival of neurons in 1% O2.	Oxygen	144-146	vascular endothelial growth factor A	Mus musculus	98-102
16038871-6	2005	On the other hand, an elevated level of plastid terminal oxidase and the lack of F0 "dark rise" in fluorescence measurements suggest an enhanced plastid terminal oxidase-mediated electron flow to O2 in Delta rbcL thylakoids.	Oxygen	196-198	RuBisCO large subunit	Nicotiana tabacum	208-212
16759511-11	2006	CONCLUSION: Prophylactic administration of PS to the preterm neonates with high risk of RDS effectively decreases the incidence of RDS, development of severe cases and mortality, shorten the disease course, the duration of supplemental oxygen administration and assisted ventilation, thus decreasing the potential morbidity associated with long-term oxygen supplement and assisted ventilation.	Oxygen	236-242	peripherin 2	Homo sapiens	88-91
16759511-11	2006	CONCLUSION: Prophylactic administration of PS to the preterm neonates with high risk of RDS effectively decreases the incidence of RDS, development of severe cases and mortality, shorten the disease course, the duration of supplemental oxygen administration and assisted ventilation, thus decreasing the potential morbidity associated with long-term oxygen supplement and assisted ventilation.	Oxygen	350-356	peripherin 2	Homo sapiens	88-91
16804566-6	2006	This insures that its mGluR3 signal function reflects current levels of neuronal stimulation, so that Glc and oxygen can be supplied in a timely manner for metabolic replacement of ATP stocks depleted during the repolarization process.	Oxygen	110-116	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	22-28
34962378-5	2022	Benefiting from the above superiorities of morphological and chemical compositions, this self-supported CoP@Fe-CoP/NC/NF heterostructure can drive alkaline hydrogen evolution reaction and oxygen evolution reaction with overpotentials of 97 and 270 mV to yield 100 mA cm-2, respectively.	Oxygen	188-194	caspase recruitment domain family member 16	Homo sapiens	111-114
16288478-1	2006	Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes.	Oxygen	81-87	N-myc downstream regulated 1	Homo sapiens	135-140
16288478-1	2006	Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes.	Oxygen	81-87	N-myc downstream regulated 1	Homo sapiens	141-146
16229574-2	2005	The importance of vibrational-to-electronic (V-E) energy transfer mediated by spin-orbit coupling in the collisional removal of O2(X 3Sigmag-,upsilon&gt;or=26) by O2 has been reported in a recent communication [F. Dayou, J. Campos-Martinez, M. I. Hernandez, and R. Hernandez-Lamoneda, J. Chem.	Oxygen	128-130	spindlin 1	Homo sapiens	78-82
16229574-2	2005	The importance of vibrational-to-electronic (V-E) energy transfer mediated by spin-orbit coupling in the collisional removal of O2(X 3Sigmag-,upsilon&gt;or=26) by O2 has been reported in a recent communication [F. Dayou, J. Campos-Martinez, M. I. Hernandez, and R. Hernandez-Lamoneda, J. Chem.	Oxygen	163-165	spindlin 1	Homo sapiens	78-82
16229574-9	2005	The spin-orbit coupling between the ground and second excited states is already nonzero in the O2+O2 dissociation limit and keeps its asymptotic value up to relatively short intermolecular separations, where the coupling increases for intramolecular distances close to the equilibrium of the isolated diatom.	Oxygen	95-97	spindlin 1	Homo sapiens	4-8
16229574-9	2005	The spin-orbit coupling between the ground and second excited states is already nonzero in the O2+O2 dissociation limit and keeps its asymptotic value up to relatively short intermolecular separations, where the coupling increases for intramolecular distances close to the equilibrium of the isolated diatom.	Oxygen	98-100	spindlin 1	Homo sapiens	4-8
16436386-6	2006	These structural characteristics of tyrosinase suggest that, in the reaction that catalyzes the ortho-hydroxylation of monophenol, one of the two Cu(II) ions is coordinated by the peroxide-originated oxygen bound to the substrate.	Oxygen	200-206	tyrosinase	Homo sapiens	36-46
34850509-3	2022	This complex exhibits a 16/18 O2 -isotope sensitive nu(O-O) stretch at 1128 cm-1 concomitantly with a single nu(Fe-O2 ) at 555 cm-1 , indicating it is an eta1 -superoxo ("end-on") iron(III) complex.	Oxygen	30-32	secreted phosphoprotein 1	Homo sapiens	154-158
16613696-8	2006	Plasma ADM levels were significantly negatively correlated with mean systemic arterial pressure, oxygen saturation in mixed vein and oxygen saturation in systemic artery (r=-0.401, -0.562, -0.600, respectively; P &lt; 0.01) but positively correlated with pulmonary vascular resistance (r=0.406; P &lt; 0.01).	Oxygen	97-103	adrenomedullin	Homo sapiens	7-10
16613696-8	2006	Plasma ADM levels were significantly negatively correlated with mean systemic arterial pressure, oxygen saturation in mixed vein and oxygen saturation in systemic artery (r=-0.401, -0.562, -0.600, respectively; P &lt; 0.01) but positively correlated with pulmonary vascular resistance (r=0.406; P &lt; 0.01).	Oxygen	133-139	adrenomedullin	Homo sapiens	7-10
15636581-4	2005	Insect cells attached to poly(vinyl alcohol) matrixes packed in the RFB and grew confluently; 5.6 m-units/ml beta3GnT was produced under the conditions of pure oxygen supply and addition of glucose and glutamine.	Oxygen	160-166	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	109-117
16096458-1	2005	OBJECTIVES: MalPEG-hemoglobin, 4 g/dL (MP4), is a hemoglobin-based oxygen carrier with a low hemoglobin concentration, low P50 (oxygen half-saturation pressure of hemoglobin), high colloid osmotic pressure, and high viscosity.	Oxygen	67-73	HGB	Sus scrofa	19-29
16096458-1	2005	OBJECTIVES: MalPEG-hemoglobin, 4 g/dL (MP4), is a hemoglobin-based oxygen carrier with a low hemoglobin concentration, low P50 (oxygen half-saturation pressure of hemoglobin), high colloid osmotic pressure, and high viscosity.	Oxygen	67-73	HGB	Sus scrofa	50-60
16096458-1	2005	OBJECTIVES: MalPEG-hemoglobin, 4 g/dL (MP4), is a hemoglobin-based oxygen carrier with a low hemoglobin concentration, low P50 (oxygen half-saturation pressure of hemoglobin), high colloid osmotic pressure, and high viscosity.	Oxygen	67-73	HGB	Sus scrofa	50-60
16096458-1	2005	OBJECTIVES: MalPEG-hemoglobin, 4 g/dL (MP4), is a hemoglobin-based oxygen carrier with a low hemoglobin concentration, low P50 (oxygen half-saturation pressure of hemoglobin), high colloid osmotic pressure, and high viscosity.	Oxygen	67-73	HGB	Sus scrofa	50-60
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	solute carrier family 2 member 1	Homo sapiens	204-209
16098620-1	2005	BACKGROUND AND PURPOSE: This study was designed to determine the oxygen dependency for expression of the endogenous hypoxic markers carbonic anhydrase IX (protein: CAIX/gene: CA9), glucose transporter 1 (GLUT1/GLUT1), osteopontin (OPN/OPN) and lactate dehydrogenase A (LDH-A/LDHA), and how this expression was influenced by extracellular pH (pHe).	Oxygen	65-71	solute carrier family 2 member 1	Homo sapiens	210-215
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	neuroglobin	Homo sapiens	113-124
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	neuroglobin	Homo sapiens	126-129
16505036-1	2006	PURPOSE: The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.	Oxygen	87-93	neuroglobin	Homo sapiens	200-203
16024619-2	2005	VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	20-26	von Hippel-Lindau tumor suppressor	Mus musculus	0-3
34850509-3	2022	This complex exhibits a 16/18 O2 -isotope sensitive nu(O-O) stretch at 1128 cm-1 concomitantly with a single nu(Fe-O2 ) at 555 cm-1 , indicating it is an eta1 -superoxo ("end-on") iron(III) complex.	Oxygen	115-117	secreted phosphoprotein 1	Homo sapiens	154-158
34252249-0	2022	Forward chemical genetic screen for oxygen-dependent cytotoxins uncovers new covalent fragments that target GPX4.	Oxygen	36-42	glutathione peroxidase 4	Homo sapiens	108-112
15883163-8	2005	By spectral analysis, flow cytometry, reverse transcriptase-PCR, immunocytochemistry, and immunoprecipitation it was shown that the extra-mitochondrial oxygen consumption was contributed by the NOX2 and NOX4 isoforms of the O2-*.	Oxygen	152-158	cytochrome b-245 beta chain	Homo sapiens	194-198
16518308-0	2006	Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.	Oxygen	35-41	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	Mus musculus	0-10
16518308-0	2006	Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.	Oxygen	35-41	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	Mus musculus	12-18
16518308-4	2006	The purpose of the present study was to determine if the expression pattern of Tbdn-1 is altered during oxygen-induced retinal neovascularization in mice and in a specimen of stage 3 human ROP.	Oxygen	104-110	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	Mus musculus	79-85
16518308-6	2006	RESULTS: The pattern of Tbdn-1 expression during the course of oxygen-induced retinal neovascularization in mice suggests a regulating role in neonatal retinopathy.	Oxygen	63-69	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	Mus musculus	24-30
16518308-7	2006	Retinal lesions from oxygen-induced retinal neovascularization in mice display suppression of retinal endothelial Tbdn-1 protein expression in conjunction with an increase in expression of proliferating cell nuclear antigen (a marker of proliferation) and alpha smooth muscle actin (a marker of myofibroblastic cells).	Oxygen	21-27	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	Mus musculus	114-120
16462017-7	2006	All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17.	Oxygen	106-112	complement C3	Homo sapiens	145-148
15924948-6	2005	Hence, at a constant photon flux the concentration of dissolved molecular oxygen within the zones of photo and thermal radical reactions limits the rate of mineralization, i.e. the rate of TOC diminution.	Oxygen	74-80	rhomboid 5 homolog 2	Homo sapiens	189-192
15985531-0	2005	Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.	Oxygen	9-15	5-hydroxytryptamine (serotonin) receptor 2B	Mus musculus	96-102
34953386-5	2022	Meanwhile, the increase of O2 in tumor-site can affect the metabolism of tumor cells and regulatory T (Treg) cells to reduce cancer cells proliferation by down-regulating the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and c-Myc.	Oxygen	27-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	238-243
15879294-4	2005	We have investigated the possibility that the hypoxia-inducible factors HIF-1alpha and HIF-2alpha, which are activated by oxygen deprivation, are involved in this resetting process.	Oxygen	122-128	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	72-82
15879294-4	2005	We have investigated the possibility that the hypoxia-inducible factors HIF-1alpha and HIF-2alpha, which are activated by oxygen deprivation, are involved in this resetting process.	Oxygen	122-128	endothelial PAS domain protein 1	Rattus norvegicus	87-97
15879294-9	2005	After exposure to hypoxia (8% O(2), 6 h), the expression of HIF-1alpha was selectively up-regulated in glomus cells and apparent translocation of both HIF-1alpha and HIF-2alpha to the nucleus was observed.	Oxygen	30-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	60-70
15879294-9	2005	After exposure to hypoxia (8% O(2), 6 h), the expression of HIF-1alpha was selectively up-regulated in glomus cells and apparent translocation of both HIF-1alpha and HIF-2alpha to the nucleus was observed.	Oxygen	30-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	151-161
16390493-1	2006	Expression of brain-derived neurotrophic factor (BDNF) is sensitive to changes in oxygen availability, suggesting that BDNF may be involved in adaptive responses to oxidative stress.	Oxygen	82-88	brain-derived neurotrophic factor	Rattus norvegicus	14-47
16390493-1	2006	Expression of brain-derived neurotrophic factor (BDNF) is sensitive to changes in oxygen availability, suggesting that BDNF may be involved in adaptive responses to oxidative stress.	Oxygen	82-88	brain-derived neurotrophic factor	Rattus norvegicus	49-53
16390493-1	2006	Expression of brain-derived neurotrophic factor (BDNF) is sensitive to changes in oxygen availability, suggesting that BDNF may be involved in adaptive responses to oxidative stress.	Oxygen	82-88	brain-derived neurotrophic factor	Rattus norvegicus	119-123
15879294-9	2005	After exposure to hypoxia (8% O(2), 6 h), the expression of HIF-1alpha was selectively up-regulated in glomus cells and apparent translocation of both HIF-1alpha and HIF-2alpha to the nucleus was observed.	Oxygen	30-34	endothelial PAS domain protein 1	Rattus norvegicus	166-176
34687331-0	2022	The neuroprotection of hyperbaric oxygen therapy against traumatic brain injury via NF-kappaB/MAPKs-CXCL1 signaling pathways.	Oxygen	34-40	C-X-C motif chemokine ligand 1	Rattus norvegicus	100-105
16113801-9	2005	Exposure of neonatal mice to chronic hypoxia (10% O2), a stimulus that leads to an arrest of lung development, resulted in upregulation of MMP-2 with a concomitant downregulation of TIMP-2.	Oxygen	50-52	matrix metallopeptidase 2	Mus musculus	139-144
16493832-1	2006	A solid source of "active" oxygen (acetylperoxyborate, APB), when dissolved in aqueous solution in the presence of a single-site microporous catalyst containing redox centres (Fe(III)AlPO-31, Mn(III)AlPO-5, Fe(III)AlPO-5), converts cyclohexane with high efficiency (ca.	Oxygen	27-33	arginyl aminopeptidase	Homo sapiens	55-58
16503287-3	2006	The ES cells in 40% O2 maintained an octamer-binding transcription factor 4 (Oct-4; a marker of pluripotent undifferentiated ES cells) gene expression level higher than that at other oxygen tensions.	Oxygen	20-22	POU domain, class 5, transcription factor 1	Mus musculus	37-75
16503287-3	2006	The ES cells in 40% O2 maintained an octamer-binding transcription factor 4 (Oct-4; a marker of pluripotent undifferentiated ES cells) gene expression level higher than that at other oxygen tensions.	Oxygen	20-22	POU domain, class 5, transcription factor 1	Mus musculus	77-82
34850458-6	2022	The shifting and intensity enhancement of the CCl2 band manifests the back-donation and conjugation effect, which are the result of the presence of nitrogen atom adjoining the dichloromethyl groups and the oxygen in the sulfur dioxide group attached among the amino group and the chlorophenyl ring, respectively, which enhances bioactivity.	Oxygen	206-212	C-C motif chemokine ligand 2	Homo sapiens	46-50
16503287-4	2006	The EB formed in 40% O2 maintained an Oct-4 gene expression level higher than that at other oxygen tensions.	Oxygen	21-23	POU domain, class 5, transcription factor 1	Mus musculus	38-43
16503287-5	2006	The generation of cardiomyocytes and the decline in Oct-4 gene expression level were earliest in the EB formed in 20% O2.	Oxygen	118-120	POU domain, class 5, transcription factor 1	Mus musculus	52-57
15802268-7	2005	Thus, a combination of low oxygen tension and overexpression of EGFR within the primary tumor of NSCLC may provide the microenvironmental signals necessary to upregulate CXCR4 expression and promote metastasis.	Oxygen	27-33	C-X-C motif chemokine receptor 4	Homo sapiens	170-175
34482636-6	2022	ATG13 S318 phosphorylation and autophagosome formation was dependent upon ATM, and activation of ATM was dependent on reactive oxygen species.	Oxygen	127-133	ATM serine/threonine kinase	Homo sapiens	97-100
15939090-2	2005	Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts.	Oxygen	39-41	KRAS proto-oncogene, GTPase	Rattus norvegicus	53-56
16136272-6	2006	Relative PDGF-B mRNA and secretion of PDGF-B protein were significantly elevated at 1% oxygen.	Oxygen	87-93	platelet derived growth factor subunit B	Homo sapiens	9-15
16136272-6	2006	Relative PDGF-B mRNA and secretion of PDGF-B protein were significantly elevated at 1% oxygen.	Oxygen	87-93	platelet derived growth factor subunit B	Homo sapiens	38-44
16136272-7	2006	Following transfection of HIF1-alpha siRNA at 1% oxygen, PDGF-B expression was significantly suppressed at mRNA level.	Oxygen	49-55	platelet derived growth factor subunit B	Homo sapiens	57-63
16374431-3	2006	To investigate the role of HIF in kidney development, we analyzed the temporal and spatial expression of the oxygen regulated HIF-1alpha and -2alpha subunits at different stages of rat and human kidney development.	Oxygen	109-115	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	126-148
15817640-0	2005	Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function.	Oxygen	0-6	myoglobin	Mus musculus	45-54
15778083-1	2005	The tyrosinase/oxygen enzymatic system catalyses the orthohydroxylation of L-tyrosine to L-dopa and the oxidation of this to dopaquinone, which evolves non-enzymatically towards to form melanins.	Oxygen	15-21	tyrosinase	Homo sapiens	4-14
15778083-5	2005	Two of these effects are its antagonism and synergy as regards the monophenolase and diphenolase activities, respectively, of tyrosinase/oxygen in the initial steps that trigger melanogenesis.	Oxygen	137-143	tyrosinase	Homo sapiens	126-136
16352964-12	2005	Subsequent intervention with 0.1 microM adrenomedullin redistributed blood flow back toward the mucosa, causing an improvement of mucosal hemoglobin oxygenation and of organ oxygen uptake.	Oxygen	149-155	adrenomedullin	Rattus norvegicus	40-54
34971428-8	2021	In a model of oxygen-induced retinopathy (OIR), eNOS deficient mice are protected during the initial vaso-obliterative phase, have reduced pathological neovascularization, and retinal endothelial tip cells have fewer filopodia.	Oxygen	14-20	nitric oxide synthase 3, endothelial cell	Mus musculus	48-52
23345908-1	2005	Neuroglobin (Ngb) is a small globular protein that binds diatomic ligands like oxygen, carbon monoxide (CO) and nitric oxide at a heme prosthetic group.	Oxygen	79-85	neuroglobin	Homo sapiens	0-11
23345908-1	2005	Neuroglobin (Ngb) is a small globular protein that binds diatomic ligands like oxygen, carbon monoxide (CO) and nitric oxide at a heme prosthetic group.	Oxygen	79-85	neuroglobin	Homo sapiens	13-16
16130061-5	2005	INTERVENTIONS: After sedation and the induction of anesthesia, animals underwent either tracheal intubation and ventilation for 5 hours with 1.0% end-tidal halothane in oxygen (HAL-O(2) , n = 5) or air (HAL-air, n = 5) or time-control recovery while spontaneously breathing oxygen (TC-O(2) , n = 5) or air (TC-air, n = 5) for 5 hours.	Oxygen	169-175	histidine ammonia-lyase	Oryctolagus cuniculus	177-180
34668282-3	2021	We further propose the inhibition of the oxygen escape for achieving stable 4.6V LiCoO 2 by tailoring the Co3d and O2p band center and enlarging their band gap with MgF 2 doping.	Oxygen	41-47	signal transducer and activator of transcription 5A	Homo sapiens	165-168
15793311-2	2005	Neuroglobin is a respiratory protein thought to play an essential role in oxygen homeostasis of neuronal cells.	Oxygen	74-80	neuroglobin	Homo sapiens	0-11
15793311-10	2005	Our results clearly demonstrate an association of neuroglobin and mitochondria, thus supporting the hypothesis that neuroglobin is a respiratory protein that supplies oxygen to the respiratory chain.	Oxygen	167-173	neuroglobin	Homo sapiens	50-61
15793311-10	2005	Our results clearly demonstrate an association of neuroglobin and mitochondria, thus supporting the hypothesis that neuroglobin is a respiratory protein that supplies oxygen to the respiratory chain.	Oxygen	167-173	neuroglobin	Homo sapiens	116-127
16162493-5	2005	Moreover, a structural basis for R chiral specificity is also revealed; creation of a small oxygen pocket next to Gly(428) (Ala in all S-LOX isozymes) promoted C-8 oxygenation with R chirality on the activated fatty acid substrate.	Oxygen	92-98	lysyl oxidase	Homo sapiens	137-140
34959594-0	2021	High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients.	Oxygen	77-83	sialic acid binding Ig like lectin 1	Homo sapiens	5-10
16287327-7	2005	Since the magnetic moment resides on a light element (oxygen), spin-orbit interactions are considerably reduced compared to other half-metals.	Oxygen	54-60	spindlin 1	Homo sapiens	63-67
16185646-6	2005	In addition, NO-based modifications of proteins and peptides on nonsulfur groups (e.g., carbon, oxygen, nitrogen) are detected on DAF gels.	Oxygen	96-102	CD55 molecule (Cromer blood group)	Homo sapiens	130-133
15862605-3	2005	For the N-reduction of benzamidoxime an oxygen-insensitive liver microsomal enzyme system that required cytochrome b5, NADH-cytochrome b5 reductase and a cytochrome P450 isoenzyme of the subfamily 2D has been described.	Oxygen	40-46	cytochrome b5 type A	Sus scrofa	104-117
15862605-3	2005	For the N-reduction of benzamidoxime an oxygen-insensitive liver microsomal enzyme system that required cytochrome b5, NADH-cytochrome b5 reductase and a cytochrome P450 isoenzyme of the subfamily 2D has been described.	Oxygen	40-46	cytochrome b5 type A	Sus scrofa	124-137
15879309-2	2005	It has been shown that SNO-Hb behaves as a nitric oxide (NO) donor at low oxygen tensions.	Oxygen	74-80	strawberry notch homolog 2	Homo sapiens	23-26
34944075-4	2021	The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions.	Oxygen	246-252	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	155-162
15879309-3	2005	This property, in combination with oxygen transport capacity, suggests that SNO-Hb may have unique potential to reoxygenate hypoxic tissues.	Oxygen	35-41	strawberry notch homolog 2	Homo sapiens	76-79
15879309-4	2005	The present study was designed to test the idea that the allosteric properties of SNO-Hb could be manipulated to enhance oxygen delivery in a hypoxic tumor.	Oxygen	121-127	strawberry notch homolog 2	Homo sapiens	82-85
15879309-5	2005	Using Laser Doppler flowmetry, we showed that SNO-Hb infusion to animals breathing 21% O2 reduced tumor perfusion without affecting blood pressure and heart rate.	Oxygen	87-89	strawberry notch homolog 2	Homo sapiens	46-49
15879309-6	2005	Raising the pO2 (100% O2) slowed the release of NO bioactivity from SNO-Hb (ie, prolonged the plasma half-life of the SNO in Hb), preserved tumor perfusion, and raised the blood pressure.	Oxygen	13-15	strawberry notch homolog 2	Homo sapiens	68-71
15879309-6	2005	Raising the pO2 (100% O2) slowed the release of NO bioactivity from SNO-Hb (ie, prolonged the plasma half-life of the SNO in Hb), preserved tumor perfusion, and raised the blood pressure.	Oxygen	13-15	strawberry notch homolog 2	Homo sapiens	118-121
15879309-9	2005	Overall, these results indicate that the properties of SNO-Hb are attributable to allosteric control of NO release by oxygen in central as well as peripheral issues.	Oxygen	118-124	strawberry notch homolog 2	Homo sapiens	55-58
16282134-7	2005	TUNEL analysis was performed to determine if TNFR-mice exhibited a reduced number of apoptotic cells after oxygen-induced retinopathy.	Oxygen	107-113	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	45-49
16283871-10	2005	Anti-VEGF antibody abrogated the angiogenic effect of both VEGF and increased oxygen tension.	Oxygen	78-84	vascular endothelial growth factor A	Mus musculus	5-9
34890296-11	2022	Trx activates MKK4-p38MAPK-PGC1alpha pathway leading to rescue of UCP2 and decreased O2 - generation in hyperoxia.	Oxygen	85-87	mitogen-activated protein kinase kinase 4	Mus musculus	14-18
16146466-0	2005	Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute lung injury involves heme oxygenase-1.	Oxygen	11-17	heme oxygenase 1	Rattus norvegicus	87-103
15994466-5	2005	MEASUREMENTS AND MAIN RESULTS: The 60% oxygen-mediated lung injury was associated with increased lung mRNAs for hepatocyte growth factor and c-Met, relative to air-exposed control lungs, at Day 7 after birth.	Oxygen	39-45	hepatocyte growth factor	Rattus norvegicus	112-136
15994466-6	2005	After exposure to 60% oxygen, immunoreactive HGF was increased at Days 4 and 7, and immunoreactive c-Met was increased at Day 14.	Oxygen	22-28	hepatocyte growth factor	Rattus norvegicus	45-48
15994466-9	2005	CONCLUSIONS: HGF and its c-Met receptor are required for normal postnatal alveolar formation from secondary crests, and are upregulated during 60% oxygen-induced neonatal lung injury.	Oxygen	147-153	hepatocyte growth factor	Rattus norvegicus	13-16
15900343-1	2005	The fabrication process of highly porous SnO(2) thick film by reaction between tin ions and oxygen gas generated by an anodic applied potential on substrates in SnCl(2) aqueous solution is reported; moreover, we succeeded in forming porous SnO(2) micropatterns through site-selective deposition on a Pt-patterned F-doped SnO(2)(FTO) coated substrate .	Oxygen	92-98	strawberry notch homolog 2	Homo sapiens	41-44
15900343-1	2005	The fabrication process of highly porous SnO(2) thick film by reaction between tin ions and oxygen gas generated by an anodic applied potential on substrates in SnCl(2) aqueous solution is reported; moreover, we succeeded in forming porous SnO(2) micropatterns through site-selective deposition on a Pt-patterned F-doped SnO(2)(FTO) coated substrate .	Oxygen	92-98	strawberry notch homolog 2	Homo sapiens	240-243
15900343-1	2005	The fabrication process of highly porous SnO(2) thick film by reaction between tin ions and oxygen gas generated by an anodic applied potential on substrates in SnCl(2) aqueous solution is reported; moreover, we succeeded in forming porous SnO(2) micropatterns through site-selective deposition on a Pt-patterned F-doped SnO(2)(FTO) coated substrate .	Oxygen	92-98	strawberry notch homolog 2	Homo sapiens	240-243
15897452-6	2005	ING4 directly associates with the HIF prolyl hydroxylase, an Fe(II)-dependent oxygenase previously shown to mediate HIF stability as a function of oxygen availability.	Oxygen	78-84	inhibitor of growth family member 4	Homo sapiens	0-4
15907468-8	2005	The structures allow formulation of a novel oxygenase mechanism whereby FGE utilizes molecular oxygen to generate FGly via a cysteine sulfenic acid intermediate.	Oxygen	44-50	sulfatase modifying factor 1	Homo sapiens	72-75
34889520-0	2022	In Situ Anchoring Co-N-C Nanoparticles on Co4 N Nanosheets toward Ultrastable Flexible Self-Supported Bifunctional Oxygen Electrocatalyst Enables Recyclable Zn-Air Batteries Over 10 000 Cycles and Fast Charging.	Oxygen	115-121	complement C4A (Rodgers blood group)	Homo sapiens	42-45
15563275-2	2005	Three human PHDs (prolyl hydroxylase domain proteins, PHD1-PHD3) initiate oxygen-dependent degradation of HIF-alpha-subunits in normoxia.	Oxygen	74-80	egl-9 family hypoxia inducible factor 3	Homo sapiens	59-63
16086034-2	2005	The aim of this study was to investigate the molecular mechanisms involved in the PlGF effects on proliferation and contraction of VSMCs previously exposed to hypoxia (3% O2).	Oxygen	171-173	placental growth factor	Rattus norvegicus	82-86
16136514-0	2005	Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes.	Oxygen	119-125	solute carrier family 2 member 1	Homo sapiens	65-70
16136514-0	2005	Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes.	Oxygen	119-125	solute carrier family 2 member 3	Homo sapiens	75-80
15845009-12	2005	This preference was found to be reversed in the monoformyl-substituted systems (50a,b, 51a,b), where the syn conformer (when formyl oxygen is near the selenium) is energetically more favorable than the anti conformer.	Oxygen	132-138	synemin	Homo sapiens	105-108
34890456-0	2021	Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis.	Oxygen	78-84	NEP-interacting protein 2	Arabidopsis thaliana	37-41
16179982-1	2005	In this study, a dissolved oxygen (DO)-stat fed-batch process was conducted in a pressurized 75-L bioreactor, resulting in the production of the short version of human leukotactin-1 (shLkn-1) using Pichia pastoris as the host, with control of the DO-stat profile and an extension of the recombinant shLkn-1 production phase.	Oxygen	27-33	C-C motif chemokine ligand 15	Homo sapiens	168-181
34890456-3	2021	NIP2;1 expression is limited to the "anoxia core" region of the root stele under normal growth conditions, but shows substantial induction (up to 1,000-fold by 2-4 h of hypoxia) by low oxygen stress, and accumulation in all root tissues.	Oxygen	185-191	NEP-interacting protein 2	Arabidopsis thaliana	0-4
34553403-0	2021	Novel, De Novo, Beta-Globin Variant with Decreased Oxygen Affinity (HBB:C.317T>A, "Hemoglobin St. George") in a Healthy Child with Low Oxygen Saturations and Anemia.	Oxygen	51-57	hemoglobin subunit beta	Homo sapiens	16-27
16309593-5	2005	We found that mitochondrial oxygen uptake was significantly reduced in kidneys after HO-1 induction and, in a similar fashion, CO-RMs inhibited mitochondrial function in a concentration-dependent manner.	Oxygen	28-34	heme oxygenase 1	Rattus norvegicus	85-89
15591411-6	2005	Rac1 and RhoA rapidly respond to changes in oxygen tension, and their activity depends on NADPH oxidase- and PI3 kinase-dependent production of ROS.	Oxygen	44-50	Rac family small GTPase 1	Homo sapiens	0-4
15793238-2	2005	AR(L-/Y) mice were euphagic compared with the wild-type male (AR(X/Y)) controls, but they were also less dynamic and consumed less oxygen.	Oxygen	131-137	androgen receptor	Mus musculus	0-2
16309593-8	2005	In summary, the results indicate that HO-1 induction and enhanced CO decrease renal oxygen consumption and alter mitochondrial function suggesting that CO could be a physiological regulator of mitochondrial oxidative phosphorylation.	Oxygen	84-90	heme oxygenase 1	Rattus norvegicus	38-42
34553403-0	2021	Novel, De Novo, Beta-Globin Variant with Decreased Oxygen Affinity (HBB:C.317T>A, "Hemoglobin St. George") in a Healthy Child with Low Oxygen Saturations and Anemia.	Oxygen	135-141	hemoglobin subunit beta	Homo sapiens	16-27
15857276-0	2005	Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy.	Oxygen	156-162	vascular endothelial growth factor A	Mus musculus	65-99
34601098-1	2021	SIRT2, a Class III HDACs, aggravates cell damage and activates caspase-3 under oxygen-glucose deprivation/reoxygenation and glucose (OGD/R) conditions.	Oxygen	79-85	sirtuin 2	Homo sapiens	0-5
15876406-8	2005	For aldosterone formation, dioxygen is bonded to C-11 and C-18 of an appropriate precursor.	Oxygen	27-35	aldo-keto reductase family 1 member C4	Homo sapiens	49-53
15994299-0	2005	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.	Oxygen	115-121	cytochrome b-245 beta chain	Homo sapiens	91-95
34721681-7	2021	Culture of HA-VSMCs under hypoxic conditions (1% O2) reduced the expression of RP11-531A24.3, and enhanced the protein expression of ANXA2 and HIF-1alpha, while knockdown of ANXA2 downregulated the protein expression of HIF-1alpha.	Oxygen	49-51	annexin A2	Homo sapiens	133-138
16167833-5	2005	Overall, the results of this study disclose novel aspects of the reactivity of 1 with the tyrosinase/O2 system and provide the first inventory of the oxidation products of catechol estrogen quinones.	Oxygen	101-103	tyrosinase	Homo sapiens	90-100
15976268-4	2005	Type XVIII collagen was found to be indispensable for angiogenesis in the eye, as also oxygen-induced neovascularization was less intense than normal in the Col18a1-/- mice.	Oxygen	87-93	collagen, type XVIII, alpha 1	Mus musculus	157-164
16366461-5	2005	NO could promote soot combustion by presenting NO2, a more powerful oxidant than O2, and the ignition temperature of soot decreased 30 degrees C. Results of TG and TPO show that the beta species oxygen on the catalyst take part in the combustion process.	Oxygen	195-201	thyroid peroxidase	Homo sapiens	164-167
15579624-2	2005	This study evaluates the expression of ADM in ALI using experimental models combining both stimuli: an in vivo model of rats treated with LPS and acute normobaric hypoxia (9% O2) and an in vitro model of rat lung cell lines cultured with LPS and exposed to hypoxia (1% O2).	Oxygen	175-177	adrenomedullin	Rattus norvegicus	39-42
15579624-2	2005	This study evaluates the expression of ADM in ALI using experimental models combining both stimuli: an in vivo model of rats treated with LPS and acute normobaric hypoxia (9% O2) and an in vitro model of rat lung cell lines cultured with LPS and exposed to hypoxia (1% O2).	Oxygen	269-271	adrenomedullin	Rattus norvegicus	39-42
15618548-2	2005	METHODS AND RESULTS: Electroporation of anti-p47phox antibody into VSMCs abrogated Ang II-mediated O2 generation, establishing the requirement for p47phox in this response.	Oxygen	99-101	neutrophil cytosolic factor 1	Homo sapiens	45-52
34420157-3	2021	In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of alpha5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells.	Oxygen	126-132	NLR family, pyrin domain containing 3	Mus musculus	335-340
15723537-1	2005	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Homo sapiens	0-11
15723537-1	2005	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	122-128	neuroglobin	Homo sapiens	13-16
16112402-2	2005	Intravenous (iv) administration of GLP-1 (50 pmol-20 nmol) elicited dose-dependent increases in the rate of whole-body O2 consumption (VO2), an index of energy expenditure, and heart rate of urethane-anesthetized rats.	Oxygen	119-121	glucagon	Rattus norvegicus	35-40
16026332-3	2005	Here, we report that in old rat cerebral cortex exposed to hypoxia, the accumulation in the cytoplasm of hypoxic inducible factor 1alpha (HIF-1alpha)--the master regulator of oxygen homeostasis--concomitant with p66(Shc) activation and reduced IkBalpha phosphorylation is associated with tissue apoptosis or necrosis.	Oxygen	175-181	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	138-148
34420157-3	2021	In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of alpha5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells.	Oxygen	126-132	PTK2 protein tyrosine kinase 2	Mus musculus	344-347
34740958-6	2021	We also show that the mechanisms supporting HIF-1alpha stabilization may differ following stimulation with short versus long dsRNA and that pyruvate kinase M2 and mitochondrial reactive oxygen species play a central role in these processes.	Oxygen	186-192	hypoxia inducible factor 1, alpha subunit	Mus musculus	44-54
15908240-2	2005	pVHL targets the oxygen sensitive alpha subunit of hypoxia-inducible factor (HIF) for proteasomal degradation, thus providing a direct link between tumorigenesis and molecular pathways critical for cellular adaptation to hypoxia.	Oxygen	17-23	von Hippel-Lindau tumor suppressor	Mus musculus	0-4
15916908-2	2005	Recent studies have shown that a protein known as CSN5 or JAB1 interacts with both the HIF-1alpha oxygen-responsive transcription factor and its oxygen-dependent regulator, the Von Hippel-Lindau (pVHL) tumor suppressor.	Oxygen	98-104	COP9 signalosome subunit 5	Homo sapiens	50-54
15916908-2	2005	Recent studies have shown that a protein known as CSN5 or JAB1 interacts with both the HIF-1alpha oxygen-responsive transcription factor and its oxygen-dependent regulator, the Von Hippel-Lindau (pVHL) tumor suppressor.	Oxygen	98-104	COP9 signalosome subunit 5	Homo sapiens	58-62
15916908-6	2005	This review will give a broad overview of known CSN5 and COP9 Signalosome functions and how these functions impact the pVHL/HIF-1alpha signaling complex and potentially other oxygen-sensitive response networks.	Oxygen	175-181	COP9 signalosome subunit 5	Homo sapiens	48-52
15622543-3	2005	We hypothesized that two caspase-1-processed cytokines, interleukin (IL)-1beta and IL-18, are involved in oxygen-induced neuronal cell death.	Oxygen	106-112	interleukin 18	Homo sapiens	83-88
15622543-7	2005	Mice deficient in IL-1 receptor-associated kinase 4 (IRAK-4), which is pivotal for both IL-1beta and IL-18 signal transduction, were protected against oxygen-mediated neurotoxicity.	Oxygen	151-157	interleukin-1 receptor-associated kinase 4	Mus musculus	18-51
15622543-7	2005	Mice deficient in IL-1 receptor-associated kinase 4 (IRAK-4), which is pivotal for both IL-1beta and IL-18 signal transduction, were protected against oxygen-mediated neurotoxicity.	Oxygen	151-157	interleukin-1 receptor-associated kinase 4	Mus musculus	53-59
15589527-0	2005	Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model.	Oxygen	31-37	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	59-70
15936961-5	2005	We previously identified two PAS proteins highly expressed in the testis: a novel isoform of the hypoxia-inducible factor (HIF)-1alpha and PASKIN, a PAS-Ser/Thr kinase related to bacterial oxygen sensing PAS-domain proteins.	Oxygen	189-195	PAS domain containing serine/threonine kinase	Homo sapiens	139-145
34899694-0	2021	Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species.	Oxygen	77-83	colony stimulating factor 1 receptor	Mus musculus	19-24
15883710-1	2005	The succinate dehydrogenase (SDH) is a mitochondrial enzyme complex with an important role in oxydative phosphorylation and intracellular oxygene sensing and signaling.	Oxygen	138-145	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	4-27
15883710-1	2005	The succinate dehydrogenase (SDH) is a mitochondrial enzyme complex with an important role in oxydative phosphorylation and intracellular oxygene sensing and signaling.	Oxygen	138-145	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	29-32
34819027-8	2021	RESULTS: When T24 cells were seeded at < 70% confluence, there was decreased PD-L1 protein (p = 0.009) and mRNA (p < 0.001) expression after culture in 0.1% oxygen.	Oxygen	157-163	CD274 molecule	Homo sapiens	77-82
15607569-10	2005	In pre-neoplastic lesions, we hypothesize that the early activation of FAS in pre-malignant cells represents a survival strategy which occurs to compensate for an insufficiency of both oxygen and dietary fatty acids due to, e.g., lack of angiogenesis.	Oxygen	185-191	fatty acid synthase	Homo sapiens	71-74
15639640-8	2005	Under low and atmospheric oxygen tension, iNOS gene expression was increased by IL-1beta, but to a lesser extent in 21% than in 1 or 5% oxygen (P&lt;0.01).	Oxygen	26-32	nitric oxide synthase 2	Bos taurus	42-46
15639640-8	2005	Under low and atmospheric oxygen tension, iNOS gene expression was increased by IL-1beta, but to a lesser extent in 21% than in 1 or 5% oxygen (P&lt;0.01).	Oxygen	136-142	nitric oxide synthase 2	Bos taurus	42-46
15639640-11	2005	COX-2 gene expression was significantly upregulated by IL-1beta in both low and atmospheric oxygen tension.	Oxygen	92-98	prostaglandin-endoperoxide synthase 2	Bos taurus	0-5
15347677-4	2004	Upon an extended 24-h fast, livers that lack PEPCK exhibit both 2-fold lower glucose production and oxygen consumption, compared with the controls, with all glucose production being derived only from glycerol.	Oxygen	100-106	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	45-50
15535964-0	2004	Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier.	Oxygen	111-117	albumin	Rattus norvegicus	55-68
34819027-9	2021	PD-L1 protein expression decreased in both 0.1% oxygen and 1% oxygen in a panel of muscle-invasive bladder cancer cells: T24 (p = 0.009 and 0.001), J82 (p = 0.008 and 0.013) and UMUC3 (p = 0.003 and 0.289).	Oxygen	48-54	CD274 molecule	Homo sapiens	0-5
34819027-9	2021	PD-L1 protein expression decreased in both 0.1% oxygen and 1% oxygen in a panel of muscle-invasive bladder cancer cells: T24 (p = 0.009 and 0.001), J82 (p = 0.008 and 0.013) and UMUC3 (p = 0.003 and 0.289).	Oxygen	62-68	CD274 molecule	Homo sapiens	0-5
34819027-11	2021	Only when cells were 100% confluent, were PD-L1 protein and mRNA levels higher in 1% versus 20% oxygen (p = 0.056 and p = 0.037).	Oxygen	96-102	CD274 molecule	Homo sapiens	42-47
15299006-0	2004	Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin.	Oxygen	52-58	neuroglobin	Homo sapiens	76-87
34739186-6	2022	Fibronectin increased NRVMs oxygen consumption rate and ATP content via FAK-ERK1/2-Drp1.	Oxygen	28-34	fibronectin 1	Rattus norvegicus	0-11
15299006-3	2004	In analogy to hemoglobin and myoglobin, neuroglobin and cytoglobin are supposedly involved in O2 storage and delivery, although their physiological role remains to be solved.	Oxygen	94-96	neuroglobin	Homo sapiens	40-51
15299006-5	2004	NGB shows both alkaline and acid Bohr effects (pH-dependent O2 affinity) and temperature-dependent enthalpy of oxygenation.	Oxygen	60-62	neuroglobin	Homo sapiens	0-3
15299006-6	2004	O2 and CO binding equilibrium studies on neuroglobin mutants strongly suggest that the bound O2 is stabilized by interactions with His(E7) and that this residue functions as a major Bohr group in the presence of Lys(E10).	Oxygen	93-95	neuroglobin	Homo sapiens	41-52
15299006-11	2004	In contrast, the lower O2 affinity in NGB does not appear compatible with a physiological role involving mitochondrial O2 supply at the low O2 tensions found within neurons.	Oxygen	23-25	neuroglobin	Homo sapiens	38-41
34739186-6	2022	Fibronectin increased NRVMs oxygen consumption rate and ATP content via FAK-ERK1/2-Drp1.	Oxygen	28-34	protein tyrosine kinase 2	Rattus norvegicus	72-75
34738228-9	2021	A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau -0.48, p=0.023).	Oxygen	63-69	microtubule associated protein tau	Homo sapiens	102-105
15461452-8	2004	Thus, the binding of phthalate or PDR(ox) to PDO(red) each results in greater reactivity of PDO with O(2).	Oxygen	101-105	PDR	Homo sapiens	34-37
34732715-4	2021	Hybridization with in-vivo 18O labeling and matrix-assisted laser desorption/ionization-tandem MS imaging reveals that PC PUFA;O2 are accumulated in cytochrome P450 2E1-expressing and glutathione-depleted hepatocytes, which are the major sites of liver injury.	Oxygen	127-129	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	149-168
15498364-4	2004	The purpose of this study was to define the effects of decreases in blood partial pressure of oxygen (PO2) on CFR as measured by MCE.	Oxygen	94-100	PO2	Sus scrofa	102-105
34769334-7	2021	Secondly, silencing DIO2 resulted in an increased reactive oxygen species, impaired activation of the mitochondrial unfolded protein response, severely impaired mitochondrial respiration and reduced cellular viability.	Oxygen	59-65	iodothyronine deiodinase 2	Homo sapiens	20-24
15450125-9	2004	RESULTS: Cell killing assays demonstrated cells over-expressing hMYH had improved survival to both increased oxygen and IR.	Oxygen	109-115	mutY DNA glycosylase	Homo sapiens	64-68
15450125-13	2004	CONCLUSION: Increased expression of the DNA glycosylase repair enzyme hMYH in A549 cells exposed to O2 and IR leads to improvements in cell survival.	Oxygen	100-102	mutY DNA glycosylase	Homo sapiens	70-74
34728640-1	2021	Oxygen isotope ratios in mantle-derived magmas that differ from typical mantle values are generally attributed to crustal contamination, deeply subducted crustal material in the mantle source or primordial heterogeneities.	Oxygen	0-6	presequence translocase associated motor 16	Homo sapiens	40-46
15514770-0	2004	Oxygen and nitrogen Lewis base adducts of [UO2(OTf)2].	Oxygen	0-6	POU class 2 homeobox 2	Homo sapiens	47-52
34728640-2	2021	Here we provide an alternative view for the origin of light oxygen-isotope signatures in mantle-derived magmas using kimberlites, carbonate-rich magmas that assimilate mantle debris during ascent.	Oxygen	60-66	presequence translocase associated motor 16	Homo sapiens	104-110
34728640-2	2021	Here we provide an alternative view for the origin of light oxygen-isotope signatures in mantle-derived magmas using kimberlites, carbonate-rich magmas that assimilate mantle debris during ascent.	Oxygen	60-66	presequence translocase associated motor 16	Homo sapiens	145-151
15366957-0	2004	Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles.	Oxygen	90-92	hemoglobin subunit gamma 2	Homo sapiens	13-26
34536041-3	2021	P/M@CasMTH1 nanoparticles comprise singlet oxygen (1 O2 )-generating MOF structures anchored with CRISPR-Cas9 systems via 1 O2 -cleavable linkers, which serve not only as a delivery vector of CRISPR-Cas9 targeting MTH1, but also as a sonoregulator to spatiotemporally activate the genome editing.	Oxygen	53-55	nudix hydrolase 1	Homo sapiens	214-218
18236095-4	2004	The diffusion capacities for the[Formula: see text] (between C3 and C9) are arbitrarily assigned.The Fick method gives incorrect results depending on the total arteriovenous diffusive shunt of oxygen[Formula: see text].	Oxygen	193-199	complement C3	Homo sapiens	61-70
34509493-5	2021	In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2.	Oxygen	175-177	complement C4A (Rodgers blood group)	Homo sapiens	84-87
15299039-12	2004	These various responses might be based on a range of oxygen-sensing signal cascades, including an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial chain such as a specialized mitochondrial, low P(O(2)) affinity cytochrome c oxidase (aa(3)) and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF prolyl-hydroxylase (PHD) and HIF asparaginyl hydroxylase, known as factor-inhibiting HIF (FIH-1).	Oxygen	53-59	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	444-449
34319445-13	2021	CONCLUSIONS: Higher aerobic training status witnessed by faster (Formula: see text)O2 kinetics led to lower between-protocol Vmax differences, particularly between CP2 vs DP.	Oxygen	83-85	ceruloplasmin	Homo sapiens	164-167
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Oxygen	47-53	malate dehydrogenase 2	Homo sapiens	179-182
15387997-9	2004	There was a significantly negative correlation between the concentration of ICAM-1 and the lowest oxygen desaturation in all the 60 OSAHS patients with and without hypertension (r = -0.368, P &lt; 0.01).	Oxygen	98-104	intercellular adhesion molecule 1	Homo sapiens	76-82
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Oxygen	192-198	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	144-148
34757278-8	2021	Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation.	Oxygen	145-151	interleukin 1 alpha	Homo sapiens	78-82
15251459-3	2004	PHD3 may therefore provide an interface between oxygen sensing and other signalling pathways.	Oxygen	48-54	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
34816101-6	2021	In contrast, Orai1-/- macrophages showed a decrease in anti-inflammatory cytokines and exhibited a suppression of mitochondrial oxygen consumption rate and inhibited mitochondrial shape transition specifically in the M2 cells.	Oxygen	128-134	ORAI calcium release-activated calcium modulator 1	Mus musculus	13-18
15236579-2	2004	The oxygen binding properties of native HbA, including the cooperativity and Bohr effect, are not substantially changed by the modification, provided care is taken to remove electrophoretically silent impurities arising from side reactions.	Oxygen	4-10	keratin 90, pseudogene	Homo sapiens	40-43
34343376-3	2021	Human MTF (hMTF) is a functional homopolymeric H-like ferritin performing the ferroxidase activity in its ferroxidase site (FS), in which Fe(II) is oxidized to Fe(III) in the presence of dioxygen.	Oxygen	187-195	ferritin mitochondrial	Homo sapiens	6-9
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	colony stimulating factor 1 (macrophage)	Mus musculus	87-92
15296653-6	2004	A substantial proportion of colonies grown under low oxygen tension in the presence of CSF-1 and GM-CSF express intestinal epithelial A33 antigen, have the expected gene expression profile, including c-fms and transcription factor c-myb, and show an appropriate epithelial cell morphology and undetectable CD45.	Oxygen	53-59	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	97-103
34343376-3	2021	Human MTF (hMTF) is a functional homopolymeric H-like ferritin performing the ferroxidase activity in its ferroxidase site (FS), in which Fe(II) is oxidized to Fe(III) in the presence of dioxygen.	Oxygen	187-195	ferritin mitochondrial	Homo sapiens	11-15
34744970-7	2021	Consistent with the sequencing results, real-time quantitative PCR and Western blot indicate that Fos was elevated at 3 h and returned to normal levels at 6 h after oxygen-glucose deprivation.	Oxygen	165-171	FBJ osteosarcoma oncogene	Mus musculus	98-101
15178829-10	2004	CONCLUSIONS: JNK inhibition prevents cell death induced by oxygen and glucose deprivation in hippocampal slice cultures in vitro and by permanent suture MCAo in vivo.	Oxygen	59-65	mitogen-activated protein kinase 8	Mus musculus	13-16
15143204-2	2004	Neuroglobin, a heme protein distantly related to hemoglobin, is thought to enhance the supply of oxygen to the neurons, the eye, and some endocrine tissues.	Oxygen	97-103	neuroglobin	Homo sapiens	0-11
34426395-5	2021	After chemical aging, the specific surface area and oxygen-containing functional groups of CAHCs were increased, which contributed to combination with Cd2+ by physical adsorption and surface complexation.	Oxygen	52-58	CD2 molecule	Homo sapiens	151-154
34227643-12	2021	We also show that ZIF-EC1 doped with cobalt can act as an efficient electrocatalyst for oxygen reduction reactions.	Oxygen	88-94	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	22-25
15140065-15	2004	However, our data suggests that tyrosinase-related protein-1, rather than tyrosinase, facilitates toxicity, possibly by catalytic conversion of the compounds, which results in the generation of radical oxygen species.	Oxygen	202-208	tyrosinase	Homo sapiens	32-42
34412405-7	2021	This study provides novel insights into the distribution of bacterial communities, and clues for understanding the responses of bacterial communities in the Bohai Sea during the transition from the oxic to oxygen-deficient zones.	Oxygen	206-212	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	163-166
15122877-2	2004	It has been reported that Ngb levels increase in neurons in response to oxygen deprivation, and that Ngb protects neurons from hypoxia.	Oxygen	72-78	neuroglobin	Homo sapiens	26-29
16158611-2	2005	Ca2+ is a key second messenger that delivers signal from the cell surface, reactive oxygen intermediates and nitric oxide are recently recognized as important mediators of T cell activation.	Oxygen	84-90	carbonic anhydrase 2	Homo sapiens	0-3
34692722-9	2021	Univariate analysis and Multivariate analysis showed four factors including age of onset, ferritin, value of ELVAR, and oxygen supplementation >4 L/min significantly value for poor prognosis in MDA5+DM patients.	Oxygen	120-126	interferon induced with helicase C domain 1	Homo sapiens	194-198
15764677-2	2005	Mucosal tissue PO2 was measured by employing two Clark-type surface oxygen electrodes.	Oxygen	68-74	PO2	Sus scrofa	15-18
15764679-1	2005	A system is described for in vivo noninvasive measurements of hemoglobin oxygen saturation (HbO2Sat) at the microscopic level.	Oxygen	73-79	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	96-99
15969380-1	2004	Previous work has demonstrated that semifluorinated alkanes CnF2n+1CmH2m+1 (FnHm diblocks), when used in conjunction with phospholipids, strongly stabilize fluorocarbon (FC)-in-water emulsions destined to be used as oxygen carriers.	Oxygen	216-222	NPHS1 adhesion molecule, nephrin	Homo sapiens	60-63
34426259-6	2021	Besides, this HPL significantly protected against tert-butyl hydroperoxide (TBHP)-induced oxidative stress as evidenced by increasing CEC viability, decreased cell death and reactive oxygen species formation, and enhanced antioxidant capacity.	Oxygen	183-189	galectin 1	Homo sapiens	14-17
15131304-2	2004	We trapped the copper-dioxygen complex in the enzyme peptidylglycine-alphahydroxylating monooxygenase (PHM) by freezing protein crystals that had been soaked with a slow substrate and ascorbate in the presence of oxygen.	Oxygen	24-30	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-101
15131304-2	2004	We trapped the copper-dioxygen complex in the enzyme peptidylglycine-alphahydroxylating monooxygenase (PHM) by freezing protein crystals that had been soaked with a slow substrate and ascorbate in the presence of oxygen.	Oxygen	24-30	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	103-106
15131304-4	2004	Given this structure, it is likely that dioxygen is directly involved in the electron transfer and hydrogen abstraction steps of the PHM reaction.	Oxygen	40-48	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	133-136
16080536-2	2005	We investigated the impact of hypoxia (1% oxygen) on the expression of cathepsin B and its natural inhibitors cystatin B and C. MATERIALS AND METHODS: Patient-matched oral carcinoma cell lines from primary tumor and lymph node metastasis were used to study the effects of hypoxia on proliferation, protein expression, and proteolytic and inhibitor activities.	Oxygen	42-48	cathepsin B	Homo sapiens	71-82
15845618-6	2005	BAT normally contributes to maintain T(C) at RT, 9 C below thermoneutrality, yet TRalpha-0/0 mice do not show signs of being cold stressed at 20-22 C. Instead, oxygen consumption is greater in TRalpha-0/0 than in wild-type mice at RT, suggesting the recruitment of an alternate, cold-activated form of thermogenesis to compensate for the lack of BAT thermogenesis.	Oxygen	160-166	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	81-88
16034640-2	2005	Earlier, we have reported that in carotid body (CB), the peripheral oxygen sensing organ, HIF-1alpha is up-regulated during hypoxia.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	90-100
15096942-9	2004	Mice that were treated with endostatin had fewer CD31+ blood vessels, worse flap perfusion at all time points, and lower oxygen tensions throughout the length of the flap.	Oxygen	121-127	collagen, type XVIII, alpha 1	Mus musculus	28-38
15171291-5	2004	The complex involving the oxygen insertion bonding Cr-O-S is separable from the normal Cr(PDC)3 complex chromatographically, thus allowing the quantification of Cr6+.	Oxygen	26-32	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	161-164
16034640-8	2005	Taken together, these results strongly indicate that a functional mitochondrial ETC is required for the stabilization of HIF-1alpha, and further the connection between HIF-1alpha and mitochondria in CB oxygen sensing is reiterated.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	121-131
34426261-5	2021	RESULTS: We revealed that, in the non-invasive MCF10DCIS cells but not in the post-EMT MCF7 cells, low oxygen availability induced the decrease of E-cadherin and the increase of vimentin and motility, that were prevented by GE administration.	Oxygen	103-109	vimentin	Homo sapiens	178-186
16034640-8	2005	Taken together, these results strongly indicate that a functional mitochondrial ETC is required for the stabilization of HIF-1alpha, and further the connection between HIF-1alpha and mitochondria in CB oxygen sensing is reiterated.	Oxygen	202-208	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	168-178
34280452-6	2021	After oxygen-glucose deprivation (OGD), miR-375-3p expression increased, while aralkylamine N-acetyltransferase (AANAT) expression and melatonin (MT) secretion decreased.	Oxygen	6-12	aralkylamine N-acetyltransferase	Rattus norvegicus	79-111
15976297-1	2005	The binuclear copper enzyme tyrosinase activates O2 to form a mu-eta2:eta2-peroxodicopper(II) complex, which oxidizes phenols to catechols.	Oxygen	49-51	tyrosinase	Homo sapiens	28-38
15044855-4	2004	Since Hph"s hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.	Oxygen	46-52	Cyclin-dependent kinase 4	Drosophila melanogaster	133-137
15044855-4	2004	Since Hph"s hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.	Oxygen	142-148	Cyclin D	Drosophila melanogaster	128-132
15044855-4	2004	Since Hph"s hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.	Oxygen	142-148	Cyclin-dependent kinase 4	Drosophila melanogaster	133-137
15287594-6	2004	Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease.	Oxygen	245-251	complement C3	Homo sapiens	102-105
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Oxygen	118-124	transferrin	Mus musculus	246-257
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Oxygen	181-187	transferrin	Mus musculus	246-257
34280452-6	2021	After oxygen-glucose deprivation (OGD), miR-375-3p expression increased, while aralkylamine N-acetyltransferase (AANAT) expression and melatonin (MT) secretion decreased.	Oxygen	6-12	aralkylamine N-acetyltransferase	Rattus norvegicus	113-118
14764916-6	2004	During graded hypoxia, VE was decreased in Cftr-/- mice at 10 and 8% O2 because of a lower f. Histology showed neither inflammation nor obstruction of airways in Cftr-/- mice.	Oxygen	69-71	cystic fibrosis transmembrane conductance regulator	Mus musculus	43-47
34447462-7	2021	By inhibiting HIF-1alpha, miR-18a-5p suppressed aerobic glycolysis in K562/ADM cells, according to the results produced by glucose uptake, lactate production, pyruvate level and ATP synthesis measurement, along with the results obtained from extracellular acidification rate and oxygen consumption rate assays.	Oxygen	279-285	microRNA 18a	Homo sapiens	26-33
15089569-0	2004	Manipulation of spin reorientation transition by oxygen surfactant growth: a combined theoretical and experimental approach.	Oxygen	49-55	spindlin 1	Homo sapiens	16-20
15923322-8	2005	Ethylene signaling mutants (ein2 and etr1) and reactive oxygen metabolism mutants (vtc1, vtc2, npq1, and cad2) were more defective in basal than acquired thermotolerance, especially under high light.	Oxygen	56-62	non-photochemical quenching 1	Arabidopsis thaliana	95-99
34639670-0	2021	Cutting Oxygen Production-Related Greenhouse Gas Emissions by Improved Compression Heat Management in a Cryogenic Air Separation Unit.	Oxygen	8-14	gastrin	Homo sapiens	45-48
15796924-1	2005	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that can reversibly bind oxygen that is expressed in the brain.	Oxygen	92-98	neuroglobin	Homo sapiens	0-11
15796924-1	2005	Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that can reversibly bind oxygen that is expressed in the brain.	Oxygen	92-98	neuroglobin	Homo sapiens	13-16
15089569-1	2004	A new procedure described to manipulate the spin reorientation transition (SRT) in ultrathin ferromagnetic films, i.e., the oxygen assisted surfactant growth of Ni monolayers (ML), reduces the surface anisotropy energy.	Oxygen	124-130	spindlin 1	Homo sapiens	44-48
33642395-7	2021	Additionally, it attenuated oxygen and glucose deprivation-induced changes in the expression of the PTEN/AKT signaling pathway as well as synaptic plasticity-related proteins in the neurons.	Oxygen	28-34	phosphatase and tensin homolog	Homo sapiens	100-104
15053633-7	2004	+.O2-, would emerge as a KIE1/2 factor in the rates of the ensuing radical chain, the magnitude of the observed KIE must be associated with the hydride transfer reaction that yields a diamagnetic species: O3 + HO2- HO3- + O2.	Oxygen	2-4	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	215-218
15053633-8	2004	HO3-/H2O3 may be the bactericidal trioxide recently identified in the antibody-catalyzed addition of O2(1Deltag) to H2O.	Oxygen	101-103	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-3
15677764-5	2005	These effects are probably related to the conjugated carbonyl oxygen in C-11, which produces reactive oxygen species by interacting with the mitochondrial respiratory chain, mainly at the level of complex I but, most likely, also with complex III.	Oxygen	62-68	RNA polymerase III subunit K	Homo sapiens	72-76
15926913-9	2005	Fucoidan also attenuated A beta-induced down-regulation of phosphorylated protein kinase C. A beta(1-42)-induced generation of reactive oxygen species was blocked by prior exposure of cultures to Fucoidan.	Oxygen	136-142	amyloid beta precursor protein	Rattus norvegicus	25-31
15926913-9	2005	Fucoidan also attenuated A beta-induced down-regulation of phosphorylated protein kinase C. A beta(1-42)-induced generation of reactive oxygen species was blocked by prior exposure of cultures to Fucoidan.	Oxygen	136-142	amyloid beta precursor protein	Rattus norvegicus	92-98
15808915-8	2005	Under hypoxic conditions (1% O2), expression of both adrenomedullin and endothelin-1 was induced in these cells.	Oxygen	29-31	adrenomedullin	Homo sapiens	53-67
15811342-4	2005	LSD1 converts oxygen to hydrogen peroxide although this reactivity is not as pronounced as that of other flavin-dependent oxidases.	Oxygen	14-20	lysine demethylase 1A	Homo sapiens	0-4
14726529-8	2004	HIF-1alpha co-immunoprecipitated with Hsp90/Hsp70 and direct binding of Hsp70 to the oxygen-dependent degradation domain (ODD) of HIF-1alpha was proven by a pull-down assay and a peptide array.	Oxygen	85-91	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
15177053-2	2004	DHEA is a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH) and as a consequence lowers NADPH levels and reduces NADPH-dependent oxygen-free radical production.	Oxygen	165-171	glucose-6-phosphate dehydrogenase	Homo sapiens	89-94
34588589-3	2021	Therefore, the purpose of this study was to compare cerebral blood volume (CBV) and cerebral haemoglobin oxygen saturation (ScO2) between healthy term neonates by mode of delivery.	Oxygen	105-111	synthesis of cytochrome C oxidase 2	Homo sapiens	124-128
14699103-3	2004	VEGF expression by macrophages is known to be stimulated by low oxygen tension as well as by inflammatory signals.	Oxygen	64-70	vascular endothelial growth factor A	Mus musculus	0-4
15841185-3	2005	To test this, we characterized the expression of A1 and the oxygen susceptibility of WT and IL-11 Tg(+) mice with normal and null A1 loci.	Oxygen	60-66	interleukin 11	Mus musculus	92-97
34526532-2	2021	This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the ventilatory responses during and following a hypoxic gas challenge (HXC, 10% O2, 90% N2) in freely moving male and female wild-type (WT) C57BL6 and eNOS knock-out (eNOS-/-) mice.	Oxygen	176-178	nitric oxide synthase 3, endothelial cell	Mus musculus	33-66
16833590-8	2005	The bare dipositive actinyl ions, UO2(2+), NpO2(2+), and PuO2(2+), were produced from the oxidation of the corresponding AnO2+ by N2O, and by O2 in the cases of UO2+ and NpO2+.	Oxygen	35-37	anoctamin 2	Homo sapiens	121-125
15036399-5	2004	In hypoxic young heart PKC alpha activation, paralleled by sustained Bax homodimerization and caspase-3 activation, along with reduced p-IKBalpha and Inhibiting Apoptosis Protein (IAP) expression, suggests that the young early and deeply undergoes the effects of lowered oxygen tension.	Oxygen	271-277	protein kinase C, alpha	Rattus norvegicus	23-32
34526532-2	2021	This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the ventilatory responses during and following a hypoxic gas challenge (HXC, 10% O2, 90% N2) in freely moving male and female wild-type (WT) C57BL6 and eNOS knock-out (eNOS-/-) mice.	Oxygen	176-178	nitric oxide synthase 3, endothelial cell	Mus musculus	68-72
34564509-7	2021	The effects of the nature and amount of PEG on the thermo-mechanical, hydration, and gas (CO2, O2) transport properties were investigated.	Oxygen	95-97	gastrin	Homo sapiens	85-88
14983025-2	2004	Macrophage expression of the murine cathelicidin-related antimicrobial peptide (CRAMP) was increased after infection by the intracellular pathogen Salmonella typhimurium, and this increase required reactive oxygen intermediates.	Oxygen	207-213	cathelicidin antimicrobial peptide	Mus musculus	36-78
14983025-2	2004	Macrophage expression of the murine cathelicidin-related antimicrobial peptide (CRAMP) was increased after infection by the intracellular pathogen Salmonella typhimurium, and this increase required reactive oxygen intermediates.	Oxygen	207-213	cathelicidin antimicrobial peptide	Mus musculus	80-85
14627695-0	2004	c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.	Oxygen	23-29	BCL2-associated X protein	Mus musculus	77-80
14627695-10	2004	Thus, oxygen deprivation-induced cell death in fibroblasts with deregulated expression of c-Myc is independent of p53 or HIF-1 status, but is dependent on the Bcl-2 family member Bax or Bak to initiate mitochondrial dependent cell death.	Oxygen	6-12	BCL2-associated X protein	Mus musculus	179-182
15708008-4	2005	The SSF-TRPM2 protein still maintained H2(O2)-induced Ca2+ influx activity.	Oxygen	42-44	transient receptor potential cation channel subfamily M member 2	Homo sapiens	8-13
15743827-6	2005	This was paralleled by a 2.7- +/- 0.5-fold increase in p47phox-TRAF4 association, membrane translocation of p47phox-TRAF4, a 2.3- +/- 0.4-fold increase in p47phox-p22phox complex formation, and a 3.2- +/- 0.2-fold increase in NADPH-dependent O2- production (all P &lt; 0.05).	Oxygen	242-244	neutrophil cytosolic factor 1	Homo sapiens	55-62
15743827-7	2005	TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron.	Oxygen	175-177	neutrophil cytosolic factor 1	Homo sapiens	6-13
34552934-8	2021	Expressing wild type alpha-synuclein alone caused inhibited growth on bacterial lawns, phagocytosis and intracellular Legionella proliferation rates, but activated mitochondrial respiration and non-mitochondrial oxygen consumption.	Oxygen	212-218	synuclein alpha	Homo sapiens	21-36
15050927-5	2004	Most species showed cytochrome b5 sensitivity to oxygen.	Oxygen	49-55	cytochrome b5 type A	Rattus norvegicus	20-33
34174709-7	2021	Furthermore, we show that an increase of reactive oxygen species levels, likely a consequence of the elevated DNA damage, is partly responsible for the lethality in orc5-1 set1Delta.	Oxygen	50-56	origin recognition complex subunit 5	Saccharomyces cerevisiae S288C	165-169
14985465-4	2004	Reintroduction of pVHL into VHL-/- cell lines restores normal oxygen-dependent regulation of these genes and suppresses tumor formation in the mouse xenograft assay.	Oxygen	62-68	von Hippel-Lindau tumor suppressor	Mus musculus	18-22
14985465-4	2004	Reintroduction of pVHL into VHL-/- cell lines restores normal oxygen-dependent regulation of these genes and suppresses tumor formation in the mouse xenograft assay.	Oxygen	62-68	von Hippel-Lindau tumor suppressor	Mus musculus	19-22
15681949-2	2005	Although cerebrospinal fluid (CSF) partial pressure of oxygen (Po2) measurement has been used to detect spinal cord ischemia (SCI), the diagnostic value and the temporal resolution of CSF Po2 measurement compared with functional assessment of the spinal cord is unknown.	Oxygen	55-61	PO2	Sus scrofa	63-66
15639143-2	2005	Intracerebroventricular (icv) injection of NMU into rats significantly reduced the food intake during dark period, and increased oxygen consumption, locomotor activity, and body temperature suggested that NMU is an anorectic and catabolic signaling molecule in mammals.	Oxygen	129-135	neuromedin U	Rattus norvegicus	205-208
34174709-7	2021	Furthermore, we show that an increase of reactive oxygen species levels, likely a consequence of the elevated DNA damage, is partly responsible for the lethality in orc5-1 set1Delta.	Oxygen	50-56	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	172-181
14570878-7	2004	In the case of products formed by oxidation of flavonoid substrates with a C-3 hydroxyl group (e.g. (2R,3R)-trans-dihydroquercetin), the results imply that oxygen exchange can occur at a stage subsequent to initial oxidation of the C-ring, probably via an enzyme-bound C-3 ketone/3,3-gem-diol intermediate.	Oxygen	156-162	complement C3	Homo sapiens	75-78
14570878-7	2004	In the case of products formed by oxidation of flavonoid substrates with a C-3 hydroxyl group (e.g. (2R,3R)-trans-dihydroquercetin), the results imply that oxygen exchange can occur at a stage subsequent to initial oxidation of the C-ring, probably via an enzyme-bound C-3 ketone/3,3-gem-diol intermediate.	Oxygen	156-162	complement C3	Homo sapiens	269-272
14997018-0	2004	Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model.	Oxygen	44-50	mitogen-activated protein kinase 11	Rattus norvegicus	155-162
15663790-11	2005	CONCLUSION: In the initiation phase of pulmonary oxygen toxicity, an increase of TNFalpha and its receptor TNFR1 leads to the activation of caspase 8 and 3 in TIIcells.	Oxygen	49-55	TNF receptor superfamily member 1A	Rattus norvegicus	107-112
15663790-11	2005	CONCLUSION: In the initiation phase of pulmonary oxygen toxicity, an increase of TNFalpha and its receptor TNFR1 leads to the activation of caspase 8 and 3 in TIIcells.	Oxygen	49-55	caspase 8	Rattus norvegicus	140-155
15649080-7	2005	Even though the atmosphere over the drop was O2 at 1 atm pressure, the wired BOD disk scavenged the O2 so effectively that the glucose-reduced FADH2 of GOx was not oxidized by O2, the natural cosubstrate of the enzyme.	Oxygen	45-47	hydroxyacid oxidase 1	Homo sapiens	152-155
15649080-7	2005	Even though the atmosphere over the drop was O2 at 1 atm pressure, the wired BOD disk scavenged the O2 so effectively that the glucose-reduced FADH2 of GOx was not oxidized by O2, the natural cosubstrate of the enzyme.	Oxygen	100-102	hydroxyacid oxidase 1	Homo sapiens	152-155
15325008-0	2004	Spin-mediated consciousness theory: possible roles of neural membrane nuclear spin ensembles and paramagnetic oxygen.	Oxygen	110-116	spindlin 1	Homo sapiens	0-4
15325008-7	2004	Thus, according our theory, the nuclear spin ensembles are the "mind-screen" with nuclear spins as its pixels, the neural membranes and proteins are the mind-screen and memory matrices, and the biologically available paramagnetic species such as O2 and NO are pixel-activating agents.	Oxygen	246-248	spindlin 1	Homo sapiens	40-44
34470658-5	2021	Functional roles of HIF1alpha, PDGFs and PDGFRs were elucidated by loss- or gain-of-function assays or chemical inhibitors, and compared in response to oxygen tension.	Oxygen	152-158	hypoxia inducible factor 1, alpha subunit	Mus musculus	20-29
15450358-4	2004	Hypoxia equivalent to an altitude of around 2 km (16.0% O2) or 5 km (10.8% O2) caused a biphasic change in both CRFR1 and R2 mRNA, there being an initial significant decline on day 1 and then an enhancement by day 2.	Oxygen	56-58	corticotropin releasing hormone receptor 1	Rattus norvegicus	112-117
15450358-4	2004	Hypoxia equivalent to an altitude of around 2 km (16.0% O2) or 5 km (10.8% O2) caused a biphasic change in both CRFR1 and R2 mRNA, there being an initial significant decline on day 1 and then an enhancement by day 2.	Oxygen	75-77	corticotropin releasing hormone receptor 1	Rattus norvegicus	112-117
34543127-8	2021	Moreover, HMGB1 inhibition rescued NO production and eliminated O2 - production in experimental NEC mice through eNOS activation.	Oxygen	64-68	nitric oxide synthase 3, endothelial cell	Mus musculus	113-117
15013640-9	2004	The increased RTP expression may reflect lower oxygen tension and/or other stress stimuli in the placenta in pre-eclampsia.	Oxygen	47-53	N-myc downstream regulated 1	Homo sapiens	14-17
15866284-0	2005	Glucose-6-phosphate dehydrogenase activity in monolayer cultures of thyroid epithelial cells: TSH and inhibition of nitrogen oxide synthase affect the enzyme activity and the oxygen sensitivity of the histochemical assay.	Oxygen	175-181	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
15866284-7	2005	The oxygen sensitivity of the assay was comparable to that reported previously in malignant cells and correlated with the activity of G6PD in primary cultures.	Oxygen	4-10	glucose-6-phosphate dehydrogenase	Homo sapiens	134-138
15866284-8	2005	We suggest that thyroid epithelial cells may be an appropriate system to investigate oxygen sensitivity of the G6PD assay as the cells demonstrate a reduced oxygen sensitivity which can be influenced by culture conditions.	Oxygen	85-91	glucose-6-phosphate dehydrogenase	Homo sapiens	111-115
15866284-8	2005	We suggest that thyroid epithelial cells may be an appropriate system to investigate oxygen sensitivity of the G6PD assay as the cells demonstrate a reduced oxygen sensitivity which can be influenced by culture conditions.	Oxygen	157-163	glucose-6-phosphate dehydrogenase	Homo sapiens	111-115
16594133-9	2005	Our results suggest that the positive inotropy by insulin and catecholamines is attributed partly to an O2 delivery-independent increase in flow to contracting muscle and redistribution of flow within the contracting muscle, which suffered from low perfusion by perfusate containing rejuvenated red cells.	Oxygen	104-106	insulin	Canis lupus familiaris	50-57
34474433-10	2021	Thus, the CP model can be applied to V(Combining Dot Above)O2 to derive the CV(Combining Dot Above)O2 and theoretically is the highest metabolic steady state that can be maintained for an extended period without fatigue.	Oxygen	59-61	ceruloplasmin	Homo sapiens	10-12
15809211-6	2005	Amongst the hypoxic infants, the number of days of oxygen supplementation correlated positively with early IL-10 levels (p=0.009; r=0.495) and negatively with the IFN-gamma/IL-10 ratio (p=0.007; r=0.495).	Oxygen	51-57	interleukin 10	Homo sapiens	107-112
15809211-6	2005	Amongst the hypoxic infants, the number of days of oxygen supplementation correlated positively with early IL-10 levels (p=0.009; r=0.495) and negatively with the IFN-gamma/IL-10 ratio (p=0.007; r=0.495).	Oxygen	51-57	interleukin 10	Homo sapiens	173-178
15150827-3	2004	Radical adducts of oxidized free sn-2 fatty acid and of oxidized intact GPC, containing one, two and three additional oxygen atoms, were assigned.	Oxygen	118-124	glycophorin C (Gerbich blood group)	Homo sapiens	72-75
15150827-5	2004	Oxidized free sn-2 fatty acids and intact GPC-DMPO adducts correspond to carbon- and oxygen-centered radicals that were identified by MS/MS as alkyl, hydroxy-alkyl, alkoxyl, hydroxy-alkoxyl, peroxyl and hydroperoxide-alkoxyl spin adducts.	Oxygen	85-91	glycophorin C (Gerbich blood group)	Homo sapiens	42-45
14673672-9	2003	T(2)-T(3) ganglionectomy significantly decreases pulse rate and systolic blood pressure, reduces myocardial oxygen demand, increases left ventricular ejection fraction and prolongs Q-T interval.	Oxygen	108-114	solute carrier family 25 member 5	Homo sapiens	0-4
14673672-9	2003	T(2)-T(3) ganglionectomy significantly decreases pulse rate and systolic blood pressure, reduces myocardial oxygen demand, increases left ventricular ejection fraction and prolongs Q-T interval.	Oxygen	108-114	solute carrier family 25 member 5	Homo sapiens	5-9
15598495-9	2005	Present evidence points to an important role of neuroglobin in neuronal oxygen homeostasis and hypoxia protection, though other functions are still conceivable.	Oxygen	72-78	neuroglobin	Homo sapiens	48-59
34474433-10	2021	Thus, the CP model can be applied to V(Combining Dot Above)O2 to derive the CV(Combining Dot Above)O2 and theoretically is the highest metabolic steady state that can be maintained for an extended period without fatigue.	Oxygen	99-101	ceruloplasmin	Homo sapiens	10-12
15598508-7	2005	The reason NOS may have recruited H4B as an electron transfer cofactor is to provide rapid coupled proton/electron transfer required for O2 activation.	Oxygen	137-139	H4 clustered histone 4	Homo sapiens	34-37
15968081-3	2005	NAAG is a selective mGluR3 agonist, one of several mGluRs that, when activated, triggers Ca2+ waves that spread to astrocytic endfeet in contact with the vascular system, where a secondary release of vasoactive agents induces a focal hyperemic response providing increased oxygen and nutrient availability to the stimulated neurons.	Oxygen	273-279	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	20-26
16255146-1	2005	Low oxygen induction of the bacterial (Vitreoscilla) hemoglobin gene (vgb) by the Arc system was investigated, as the presumptive vgb Crp site was found to have 73% identity to the Escherichia coli consensus ArcA site.	Oxygen	4-10	catabolite gene activator protein	Escherichia coli	134-137
12963742-8	2003	Importantly, MAO-B elevation was found to abolish the spare KGDH threshold capacity, which can normally be significantly inhibited before it affects maximal mitochondrial oxygen consumption rates.	Oxygen	171-177	monoamine oxidase B	Rattus norvegicus	13-18
14518958-4	2003	SODs, CAT, and APX seem to be involved in pepper fruit ripening and senescence during storage at 20 degrees C, perhaps influencing the active oxygen species levels in the fruit.	Oxygen	142-148	L-ascorbate peroxidase 3, peroxisomal	Capsicum annuum	15-18
34578546-4	2021	Sm3+ and Nd3+ co-doped causes the lattice distortion of CeO2 and generates more oxygen vacancies, which results in high ionic conductivity.	Oxygen	80-86	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	9-12
14632342-8	2003	She received oxygen for 8 h until the methemoglobin level dropped to 1%.	Oxygen	13-19	hemoglobin subunit gamma 2	Homo sapiens	38-51
16344151-10	2005	Judged by propidium iodide uptake, a selective CA1 lesion, with only minor affection on CA3, occurred in cultures exposed to oxygen-glucose deprivation for 30 min.	Oxygen	125-131	carbonic anhydrase 3	Rattus norvegicus	88-91
16344152-4	2005	The mitogen-activated protein kinases extracellular signal-regulated kinase 1 and extracellular signal-regulated kinase 2 were activated immediately after oxygen and glucose deprivation both in CA1 and in CA3/fascia dentata.	Oxygen	155-161	carbonic anhydrase 3	Rattus norvegicus	205-208
34502140-2	2021	In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 PANC-1) that enables time-resolved activation of the NF-kappaB and extracellular-signal regulated kinases (ERK)1/2 signalling pathway upon blue light-sensitive homodimerisation of the TLR4-LOV fusion protein.	Oxygen	41-47	toll like receptor 4	Homo sapiens	111-115
15808606-0	2005	Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction.	Oxygen	47-53	neuroglobin	Homo sapiens	62-73
15808606-4	2005	A promising candidate for cytoprotection against oxygen deprivation is neuroglobin (Ngb).	Oxygen	49-55	neuroglobin	Homo sapiens	71-82
15808606-4	2005	A promising candidate for cytoprotection against oxygen deprivation is neuroglobin (Ngb).	Oxygen	49-55	neuroglobin	Homo sapiens	84-87
14628919-2	2003	COX passes electrons from cytochrome c to molecular oxygen and pumps protons into the inner mitochondrial space for ATP production.	Oxygen	52-58	Cytochrome c proximal	Drosophila melanogaster	26-38
14530099-6	2003	The lowest energy pathway for the formation of the "b2" ion requires a free energy of 37.5 kcal/mol and involves the proton transfer from the amide oxygen of protonated diglycine to the hydroxyl oxygen.	Oxygen	148-154	immunoglobulin kappa variable 5-2	Homo sapiens	51-54
34502140-2	2021	In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 PANC-1) that enables time-resolved activation of the NF-kappaB and extracellular-signal regulated kinases (ERK)1/2 signalling pathway upon blue light-sensitive homodimerisation of the TLR4-LOV fusion protein.	Oxygen	41-47	toll like receptor 4	Homo sapiens	300-304
14530099-6	2003	The lowest energy pathway for the formation of the "b2" ion requires a free energy of 37.5 kcal/mol and involves the proton transfer from the amide oxygen of protonated diglycine to the hydroxyl oxygen.	Oxygen	195-201	immunoglobulin kappa variable 5-2	Homo sapiens	51-54
34485243-5	2021	Herein, we functionalize ARNR and RNR electrodes with polymeric carbon nitride (CNx) coupled with a CoO(OH)x cocatalyst for dioxygen evolution.	Oxygen	124-132	nuclear receptor subfamily 2 group E member 3	Homo sapiens	34-37
12942543-8	2003	Also, the addition of pyrolidine dithiocarbonate (PDTC) and hypoxic conditions (0.5% O2) decreased MCP-1 production in these cells.	Oxygen	85-87	chemokine (C-C motif) ligand 2	Mus musculus	99-104
15612717-0	2004	Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: the syn oxygen phenomenon.	Oxygen	125-131	synemin	Homo sapiens	121-124
34451298-6	2021	As the biaxial stretching ratio and the content of nanoclay increased, the oxygen permeability value of the PP/nanoclay nanocomposite decreased to 43.5 cc mm/m2 day atm, which was reduced by about 64% compared to PP.	Oxygen	75-81	ATM serine/threonine kinase	Homo sapiens	165-168
15612717-3	2004	In all cases, the preferred [4+2] cycloaddition pathway consisted of bonding from that pi-surface syn to the oxygen atom.	Oxygen	109-115	synemin	Homo sapiens	98-101
15642322-9	2004	Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR).	Oxygen	98-100	thioredoxin reductase 1	Homo sapiens	161-166
14560236-8	2003	eNOS overexpression increased muscle oxygen tension in a titer-dependent fashion.	Oxygen	37-43	nitric oxide synthase 3	Rattus norvegicus	0-4
14560236-11	2003	CONCLUSIONS: eNOS overexpression in an ischemic rat hind limb significantly increased skeletal muscle blood flow, muscle oxygen tension, and collateral arteries (arteriogenesis).	Oxygen	121-127	nitric oxide synthase 3	Rattus norvegicus	13-17
34401788-2	2021	This protocol summarizes the synthetic biology underlying the development of a stringent oxygen-sensitive CAR for in vitro and in vivo preclinical characterization.	Oxygen	89-95	CXADR pseudogene 1	Homo sapiens	106-109
12963641-0	2003	Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment.	Oxygen	0-6	Rac family small GTPase 1	Homo sapiens	97-101
15371490-6	2004	In conclusion, we propose that NS3, by triggering oxygen radical formation in phagocytes, may contribute to the dysfunction of antiviral lymphocytes in HCV-infected liver tissue and that strategies to circumvent oxidative stress may be useful in preventing HCV-associated carcinogenesis and facilitating lymphocyte-mediated clearance of infected cells.	Oxygen	50-56	KRAS proto-oncogene, GTPase	Homo sapiens	31-34
15804829-4	2004	Ngb is held to facilitate O2 diffusion to the mitochondria and to protect neuronal cells from hypoxic-ischemic insults, may be an oxidative stress-responsive sensor protein for signal transduction, and may carry out enzymatic activities, such as NO/O2 scavenging.	Oxygen	26-28	neuroglobin	Homo sapiens	0-3
15804829-4	2004	Ngb is held to facilitate O2 diffusion to the mitochondria and to protect neuronal cells from hypoxic-ischemic insults, may be an oxidative stress-responsive sensor protein for signal transduction, and may carry out enzymatic activities, such as NO/O2 scavenging.	Oxygen	249-251	neuroglobin	Homo sapiens	0-3
34423293-7	2021	This review highlights that integrative assessment of skeletal muscle determinants points toward efficient type-I fibers with a high mitochondrial oxidative capacity and strongly encourages well-adjusted capillarization and myoglobin concentrations to accommodate the required oxygen flux during endurance performance, especially in large muscle fibers.	Oxygen	277-283	myoglobin	Homo sapiens	224-233
15388638-8	2004	Moreover, OS-induced O2- production was blocked by noggin (a BMP antagonist), suggesting a role for BMP.	Oxygen	21-23	noggin	Mus musculus	51-57
15452620-1	2004	Ruthenium and oxygen form many ternary compounds in which the Ru 4d states and O 2p states are strongly hybridized.	Oxygen	14-20	immunoglobulin kappa variable 1D-39	Homo sapiens	79-83
15210718-0	2004	Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.	Oxygen	122-128	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	147-151
15448019-7	2004	The VHL gene product, pVHL, is the substrate recognition module of an E3 ubiquitin ligase that targets the hypoxia-inducible factor (HIF) for destruction in the presence of oxygen.	Oxygen	173-179	von Hippel-Lindau tumor suppressor	Mus musculus	4-7
15448019-7	2004	The VHL gene product, pVHL, is the substrate recognition module of an E3 ubiquitin ligase that targets the hypoxia-inducible factor (HIF) for destruction in the presence of oxygen.	Oxygen	173-179	von Hippel-Lindau tumor suppressor	Mus musculus	22-26
34211090-7	2021	Moreover, phosphorylation of the analogous site in HIF-2alpha (S435) stabilizes the protein through the same mechanism, indicating post-translational modification within the oxygen-dependent degradation domain as a mechanism of regulating the HIF-alpha subunits.	Oxygen	174-180	endothelial PAS domain protein 1	Homo sapiens	51-61
15353504-7	2004	Transmural Kv1.5 or Kv2.1 gene transfer "rescues" the developmental deficiency, conferring O2 responsiveness to preterm rabbit DAs.	Oxygen	91-93	potassium voltage-gated channel subfamily B member 1	Homo sapiens	20-25
34336787-1	2021	Indoleamine-2,3-dioxygenase (IDO1) and tryptophan dioxygenases are two heme based metalloenzymes that catalyze the tryptophan oxidation reaction by inserting molecular dioxygen to cleave the pyrrole ring.	Oxygen	168-176	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-33
15142850-8	2004	Mean left ventricular oxygen consumption measured with the NMR method was 18.6 +/- 7.7 micromol.min(-1).g dry wt(-1) and correlated well (r = 0.85, P = 0.02, n = 7) with oxygen consumption calculated from blood flow, hemoglobin, and blood gas measurements (mean 22.8 +/- 4.7 micromol.min(-1).g dry wt(-1)).	Oxygen	22-28	HGB	Sus scrofa	217-227
34285796-9	2021	A noticeable decline in activity of catalase and superoxide dismutase enzymes besides considerable increase in the levels of lipid peroxidation and reactive oxygen species was observed in head capsule homogenates of alpha-synuclein-expressing flies, which indicates obvious involvement of oxidative stress as a causal factor in SNCA E46K neurotoxicity.	Oxygen	157-163	synuclein alpha	Homo sapiens	216-231
15604726-0	2004	Bax-induced cell death of Arabidopsis is meditated through reactive oxygen-dependent and -independent processes.	Oxygen	68-74	BCL2-associated X protein	Mus musculus	0-3
34285796-9	2021	A noticeable decline in activity of catalase and superoxide dismutase enzymes besides considerable increase in the levels of lipid peroxidation and reactive oxygen species was observed in head capsule homogenates of alpha-synuclein-expressing flies, which indicates obvious involvement of oxidative stress as a causal factor in SNCA E46K neurotoxicity.	Oxygen	157-163	synuclein alpha	Homo sapiens	328-332
34277702-3	2021	Undeniably, oxygen-generating NCs and oxygen-carrying NCs can increase oxygen concentration in the hypoxic area of tumors and have also been shown to have the ability to decrease the expression of drug efflux pumps (e.g., P-gp); to increase uptake by tumor cells; to facilitate the generation of cytotoxic reactive oxide species (ROS); and to evoke systematic anti-tumor immune responses.	Oxygen	12-18	phosphoglycolate phosphatase	Homo sapiens	222-226
15316398-2	2004	Because hypoxia-inducible factor (HIF-1), a transcription factor composed of oxygen-labile HIF-1alpha and constitutive HIF-1beta subunits, regulates the physiologic/pathophysiologic response to hypoxia and ischemia, we examined the HIF-1 response in two rat models of gut ischemia-reperfusion.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	91-101
34277702-3	2021	Undeniably, oxygen-generating NCs and oxygen-carrying NCs can increase oxygen concentration in the hypoxic area of tumors and have also been shown to have the ability to decrease the expression of drug efflux pumps (e.g., P-gp); to increase uptake by tumor cells; to facilitate the generation of cytotoxic reactive oxide species (ROS); and to evoke systematic anti-tumor immune responses.	Oxygen	38-44	phosphoglycolate phosphatase	Homo sapiens	222-226
34927988-3	2021	Benefitting from the heterostructured engineering, the as-synthesized CoFe PBA@CoP presents remarkable electrocatalytic performance in 1.0 m KOH, only requiring overpotentials of 100 mV for hydrogen evolution reaction (HER) and 171 mV for oxygen evolution reaction (OER) to reach the 10 mA cm-2 current density with good stability.	Oxygen	239-245	caspase recruitment domain family member 16	Homo sapiens	79-82
15315411-2	2004	Subsequent addition of HOAc to (IMes)2Pd(O2) yields the first example of a hydroperoxopalladium species derived from molecular oxygen.	Oxygen	127-133	hypoacusis 2 (autosomal recessive)	Homo sapiens	23-27
34162925-2	2021	Our lab has developed a mouse model in which a mutated, oxygen-stable form of HIF1alpha (HIF-PPN) can be inducibly expressed in cardiomyocytes.	Oxygen	56-62	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-87
15291622-7	2004	The approach of the oxygen atom cation to acetylene goes over an energy barrier TS1 of 29 kcal/mol (relative to the reactant) and adiabatically leads the CT2 product or a weakly bound intermediate Int1 between CT2 products.	Oxygen	20-26	cancer/testis antigen 2	Homo sapiens	154-157
15291622-7	2004	The approach of the oxygen atom cation to acetylene goes over an energy barrier TS1 of 29 kcal/mol (relative to the reactant) and adiabatically leads the CT2 product or a weakly bound intermediate Int1 between CT2 products.	Oxygen	20-26	cancer/testis antigen 2	Homo sapiens	210-213
34204847-8	2021	The fraction of non-bridging oxygen sites in the vicinity of Gd3+ ions increases considerably with decreasing field strength and increasing concentration of the network modifier ions.	Oxygen	29-35	GRDX	Homo sapiens	61-64
15298922-0	2004	Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding.	Oxygen	88-94	neuroglobin	Homo sapiens	0-11
15319036-9	2004	Rats pretreated with Ad.FGF1 (10(9) or 5 x 10(9) VP) 2 days before exposure to hyperoxia (95% O2) survived, whereas rats pretreated with Ad.V152 died within 3 days.	Oxygen	94-96	fibroblast growth factor 1	Rattus norvegicus	24-28
34116546-3	2021	We performed a network meta-analysis (NMA) to pool and analyze data comparing the effect on cerebral oxygen saturation (ScO2) measured by cerebral oximetry of various inotropes/vasopressors used to treat intraoperative hypotension.	Oxygen	101-107	synthesis of cytochrome C oxidase 2	Homo sapiens	120-124
15220933-4	2004	Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35.	Oxygen	18-24	Cyclic nucleotide-binding domain-containing protein	Caenorhabditis elegans	86-91
34201387-6	2021	We further showed that increases in intracellular Ca2+ and protein kinase C alpha activation are downstream of TRPV1 for NADPH oxidase 4 upregulation and reactive oxygen species formation.	Oxygen	163-169	transient receptor potential cation channel subfamily V member 1	Sus scrofa	111-116
15236558-5	2004	These results indicate that the NH...O hydrogen bonding between the amide NH and the oxygen atom of the carboxylate contributes to strong Ca(II) binding and prevents the dissociation of the calcium-carboxylate bond.	Oxygen	85-91	carbonic anhydrase 2	Homo sapiens	138-144
15222753-3	2004	Analyses of the trajectories revealed that in the cysteine-phosphor complex of PTP1B, Gln262 oscillates freely between the bound phosphate group and Gly259 frequently forming, as observed in the crystal structure, a hydrogen bond with the backbone oxygen of Gly259.	Oxygen	248-254	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	79-84
15281531-8	2004	Oxygen 100% administration doubled subcutaneous oxygen partial pressure (PO2) (57 +/- 10 to 107 +/- 48 mm Hg, P = 0.006) and large intestine intramural PO2 (53 +/- 14 to 118 +/- 72 mm Hg, P = 0.014); intramural PO2 increased 40% in the small intestine (37 +/- 10 to 52 +/- 25 mm Hg, P = 0.004).	Oxygen	0-6	PO2	Sus scrofa	73-76
15281531-8	2004	Oxygen 100% administration doubled subcutaneous oxygen partial pressure (PO2) (57 +/- 10 to 107 +/- 48 mm Hg, P = 0.006) and large intestine intramural PO2 (53 +/- 14 to 118 +/- 72 mm Hg, P = 0.014); intramural PO2 increased 40% in the small intestine (37 +/- 10 to 52 +/- 25 mm Hg, P = 0.004).	Oxygen	0-6	PO2	Sus scrofa	152-155
15281531-8	2004	Oxygen 100% administration doubled subcutaneous oxygen partial pressure (PO2) (57 +/- 10 to 107 +/- 48 mm Hg, P = 0.006) and large intestine intramural PO2 (53 +/- 14 to 118 +/- 72 mm Hg, P = 0.014); intramural PO2 increased 40% in the small intestine (37 +/- 10 to 52 +/- 25 mm Hg, P = 0.004).	Oxygen	0-6	PO2	Sus scrofa	152-155
15281531-10	2004	Supplemental oxygen and mild hypercapnia each increased subcutaneous and intramural tissue PO2, with supplemental oxygen being most effective.	Oxygen	13-19	PO2	Sus scrofa	91-94
34088899-1	2021	Inhibition of RhoA-ROCK pathway is involved in the H2S-induced cerebral vasodilatation and H2S-mediated protection on endothelial cells against oxygen-glucose deprivation/reoxygenation injury.	Oxygen	144-150	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	51-54
15183130-9	2004	The novel spin traps are offering an alternative to PBN or POBN, especially where the higher stability of oxygen-centered radical adducts is of major importance.	Oxygen	106-112	spindlin 1	Homo sapiens	10-14
34088899-1	2021	Inhibition of RhoA-ROCK pathway is involved in the H2S-induced cerebral vasodilatation and H2S-mediated protection on endothelial cells against oxygen-glucose deprivation/reoxygenation injury.	Oxygen	144-150	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	91-94
34095262-0	2021	Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.	Oxygen	81-87	sirtuin 3	Mus musculus	0-5
15265376-1	2004	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) is one of the pivotal mediators in the response of lungs to decreased oxygen availability, and increasingly has been implicated in the pathogenesis of pulmonary hypertension.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	12-43
15265376-1	2004	BACKGROUND: Hypoxia-inducible factor-1alpha (HIF-1alpha) is one of the pivotal mediators in the response of lungs to decreased oxygen availability, and increasingly has been implicated in the pathogenesis of pulmonary hypertension.	Oxygen	127-133	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	45-55
35599166-2	2022	Five key reactions of NO with mammalian muscle myoglobin (Mb) and red blood cell hemoglobin (Hb) have been examined: (1) reversible NO binding to Fe(II) forms; (2) reversible NO binding to Fe(III) forms; (3) NO dioxygenation by Fe(II)O2 complexes; (4) autoxidation of Fe(II)NO complexes in the presence of O2; and (5) autoreduction of Fe(III)NO complexes.	Oxygen	306-308	myoglobin	Homo sapiens	47-56
15132981-1	2004	Although the primary function of myoglobin (Mb) has been considered to be cellular O2 storage and supply, recent studies have shown that Mb in addition can act as NO oxidase.	Oxygen	83-85	myoglobin	Mus musculus	33-42
15132981-1	2004	Although the primary function of myoglobin (Mb) has been considered to be cellular O2 storage and supply, recent studies have shown that Mb in addition can act as NO oxidase.	Oxygen	83-85	myoglobin	Mus musculus	44-46
15238173-12	2004	CONCLUSION: The NHE-1 specific hammerhead ribozymes induce apoptosis of PASMCs under low oxygen tension by inhibiting the increase in intracellular Ca2+ concentration, increasing bax expression and decreasing bcl-2 expression.	Oxygen	89-95	solute carrier family 9 member A1	Rattus norvegicus	16-21
12860983-1	2003	Neuroglobin (Ngb) is a newly discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	119-125	neuroglobin	Homo sapiens	13-16
12860983-2	2003	It has been reported that Ngb expression levels increase in response to oxygen deprivation and that it protects neurons from hypoxia in vitro and in vivo.	Oxygen	72-78	neuroglobin	Homo sapiens	26-29
14655544-7	2003	Finally, n-3 PUFA induce a reduction of cardiac b-oxidation and oxygen consumption in the animal.	Oxygen	64-70	pumilio RNA binding family member 3	Homo sapiens	13-17
35168048-2	2022	Combining the advantages of anodic dissolution of Ag and cathodic biocatalysis of oxygen (O2) reduction, this strategy showed an ultralow detection limit down to 10 CFU mL-1.	Oxygen	82-88	L1 cell adhesion molecule	Mus musculus	169-173
14561729-9	2003	When BeWo cells were grown under low oxygen (2%) conditions, the expression of Hash-2 decreased, while that of PACE4 increased.	Oxygen	37-43	achaete-scute family bHLH transcription factor 2	Homo sapiens	79-85
15145864-9	2004	Increased cTnI &gt; 0.6 ng/ml was associated with a slower oxygen saturation (86 (7)% v 93 (4)%, p &lt; 0.0001) and more frequent involvement of the main pulmonary arteries as assessed by spiral computed tomography (100% v 60%, p = 0.022).	Oxygen	59-65	troponin I3, cardiac type	Homo sapiens	10-14
35168048-2	2022	Combining the advantages of anodic dissolution of Ag and cathodic biocatalysis of oxygen (O2) reduction, this strategy showed an ultralow detection limit down to 10 CFU mL-1.	Oxygen	90-92	L1 cell adhesion molecule	Mus musculus	169-173
35487149-4	2022	ArsI is a non-heme ferrous iron (Fe(II))-dependent dioxygenase that catalyzes oxygen-dependent cleavage of the carbon-arsenic (C-As) bond in trivalent organoarsenicals, degrading them to inorganic As(III).	Oxygen	78-84	arylsulfatase family member I	Homo sapiens	0-4
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	Oxygen	38-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
12913161-7	2003	(d) Expression of a low-oxygen-sensitive Adh1-beta-glucuronidase reporter gene construct was more strongly induced in the invertase-overexpressing background compared with wild-type background.	Oxygen	24-30	alcohol dehydrogenase 1	Solanum tuberosum	41-45
35487149-6	2022	Understanding the catalytic mechanism of ArsI requires knowledge of the mechanisms of substrate binding and activation of dioxygen.	Oxygen	122-130	arylsulfatase family member I	Homo sapiens	41-45
12738784-2	2003	The up-regulation of BDNF expression, in turn, produced neuroprotective signals through receptor tyrosine kinase B (TrkB) and promoted cell survival under the conditions of oxygen and glucose deprivation.	Oxygen	173-179	brain derived neurotrophic factor	Homo sapiens	21-25
15148392-2	2004	Although the PAS domain of the mammalian PAS kinase (PASK) is closely related to the bacterial oxygen sensor FixL, it is unclear whether PASK activity is changed in mammalian cells in response to nutrients and might therefore contribute to signal transduction by these or other stimuli.	Oxygen	95-101	PAS domain containing serine/threonine kinase	Homo sapiens	41-51
15148392-2	2004	Although the PAS domain of the mammalian PAS kinase (PASK) is closely related to the bacterial oxygen sensor FixL, it is unclear whether PASK activity is changed in mammalian cells in response to nutrients and might therefore contribute to signal transduction by these or other stimuli.	Oxygen	95-101	PAS domain containing serine/threonine kinase	Homo sapiens	53-57
15120622-1	2004	Neuroglobin (Ngb) is a newly discovered vertebrate globin that is expressed in the brain and that can reversibly bind oxygen.	Oxygen	118-124	neuroglobin	Homo sapiens	0-11
15120622-1	2004	Neuroglobin (Ngb) is a newly discovered vertebrate globin that is expressed in the brain and that can reversibly bind oxygen.	Oxygen	118-124	neuroglobin	Homo sapiens	13-16
15120622-2	2004	It has been reported that Ngb levels increase in neurons in response to oxygen deprivation, and that it protects neurons from hypoxia.	Oxygen	72-78	neuroglobin	Homo sapiens	26-29
12714605-2	2003	It has been known for quite some time that tetrahydrobiopterin (H4B) is prone to autoxidation in the presence of molecular oxygen.	Oxygen	123-129	H4 clustered histone 4	Homo sapiens	64-67
12714605-8	2003	Our data fully confirm earlier conclusions that the direct reaction between H4B and oxygen serves as an initiation reaction for the further, rapid reaction of the thus formed superoxide with H4B, thereby very likely establishing a chain reaction process involving reduction of molecular oxygen by the intermediary tetrahydrobiopterin radical.	Oxygen	84-90	H4 clustered histone 4	Homo sapiens	76-79
12714605-8	2003	Our data fully confirm earlier conclusions that the direct reaction between H4B and oxygen serves as an initiation reaction for the further, rapid reaction of the thus formed superoxide with H4B, thereby very likely establishing a chain reaction process involving reduction of molecular oxygen by the intermediary tetrahydrobiopterin radical.	Oxygen	84-90	H4 clustered histone 4	Homo sapiens	191-194
12714605-8	2003	Our data fully confirm earlier conclusions that the direct reaction between H4B and oxygen serves as an initiation reaction for the further, rapid reaction of the thus formed superoxide with H4B, thereby very likely establishing a chain reaction process involving reduction of molecular oxygen by the intermediary tetrahydrobiopterin radical.	Oxygen	287-293	H4 clustered histone 4	Homo sapiens	76-79
12714605-8	2003	Our data fully confirm earlier conclusions that the direct reaction between H4B and oxygen serves as an initiation reaction for the further, rapid reaction of the thus formed superoxide with H4B, thereby very likely establishing a chain reaction process involving reduction of molecular oxygen by the intermediary tetrahydrobiopterin radical.	Oxygen	287-293	H4 clustered histone 4	Homo sapiens	191-194
35212449-9	2022	The level of CoQ9 significantly increased in the liver, kidney, and plasma, while the level of CoQ10 significantly increased in most organ tissues in the CoQ10 + O2 group.	Oxygen	162-164	coenzyme Q9	Rattus norvegicus	13-17
12788450-8	2003	Syn-conformers of dU are stabilized by the intramolecular hydrogen bond O5"H...O2 and the dominant conformation of the ribose ring is C2"-endo.	Oxygen	79-81	synemin	Homo sapiens	0-3
15020597-6	2004	The Fe(II)NO form of neuroglobin is oxidized to metNGB by peroxynitrite and dioxygen, two reactions that also take place in hemoglobin, albeit at lower rates.	Oxygen	76-84	neuroglobin	Homo sapiens	21-32
15134448-0	2004	Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase.	Oxygen	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	61-110
35523948-0	2022	Correction: PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production.	Oxygen	106-112	AT-rich interaction domain 1A	Homo sapiens	61-67
12782329-5	2003	The coordination of this Na(+) ion is identical to that of the K(+) ion in BCK and involves four carbonyl oxygen atoms emanating from the hinges of the ATP lid and a non-bridging oxygen of the bound nucleotide.	Oxygen	106-112	creatine kinase B	Rattus norvegicus	75-78
35504110-6	2022	The Abeta42, T-tau, and P-T181-tau levels in the plasma neuronal-derived exosomes were associated with an increased risk of cognitive impairment in OSA patients after additional adjustment for age, gender, education, vascular risk factors, apnea-hypopnea index (AHI) or oxygen reduction index (ODI).	Oxygen	270-276	microtubule associated protein tau	Homo sapiens	31-34
12626345-0	2003	Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen.	Oxygen	96-102	Fibroblast growth factor receptor 1	Rattus norvegicus	0-35
12626345-6	2003	We hypothesized that the increase in bFGF after removal from 95% O2, acting through the FGF-R1, would be critical for compensatory growth.	Oxygen	65-67	Fibroblast growth factor receptor 1	Rattus norvegicus	88-94
12766648-4	2003	Recovery of liver adenosine triphosphate, hepatocellular injury, and expression of glutamine synthetase 1, a gene that is induced by exposure of hepatocytes to low partial pressure of oxygen, were studied at 4 h of resuscitation.	Oxygen	184-190	glutamate-ammonia ligase	Rattus norvegicus	83-105
12766648-7	2003	Improved hepatocellular oxygen supply was also confirmed by restoration of the physiologic expression pattern of glutamine synthetase 1.	Oxygen	24-30	glutamate-ammonia ligase	Rattus norvegicus	113-135
14729723-0	2004	Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4).	Oxygen	25-31	HGB	Sus scrofa	107-117
15121835-7	2004	These results suggest a model in which hypoxia-inducible JNK activity is connected to oxygen sensing through increased glucose absorption and/or glycolytic activity regulated by the HIF-1 system.	Oxygen	86-92	mitogen-activated protein kinase 8	Mus musculus	57-60
35611927-6	2022	Using the mouse model of oxygen-induced retinopathy (OIR) we show that Tgfbeta signaling in activated microglia plays a role in hypoxia-induced NV where a loss in Tgfbeta signaling microglia exacerbates and prolongs retinal NV in OIR.	Oxygen	25-31	transforming growth factor alpha	Mus musculus	71-78
15080705-0	2004	Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase.	Oxygen	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	61-110
12873433-2	2003	Presumably, both acidosis and CO(2) enhance the release of oxygen from hemoglobin.	Oxygen	59-65	HGB	Sus scrofa	71-81
12873433-3	2003	The purpose of this study was to assess the relationship of oxygen utilization, CO(2) production, acidosis, and hemoglobin oxygen (Hgb-O(2)) dissociation with progressive severity of sepsis to shock.	Oxygen	123-129	HGB	Sus scrofa	112-122
35611927-6	2022	Using the mouse model of oxygen-induced retinopathy (OIR) we show that Tgfbeta signaling in activated microglia plays a role in hypoxia-induced NV where a loss in Tgfbeta signaling microglia exacerbates and prolongs retinal NV in OIR.	Oxygen	25-31	transforming growth factor alpha	Mus musculus	163-170
15107489-6	2004	The metal ion is octahedrally coordinated to the O1 and O9 oxygen atoms of the chromophore (CPH), and two water molecules act as the fifth and sixth ligands.	Oxygen	59-65	immunoglobulin kappa variable 2D-40	Homo sapiens	49-58
35609862-7	2022	Previously, we reported that the C-terminal soluble domain of mitoNEET has a specific binding site for flavin mononucleotide (FMN) and can transfer electrons from FMNH2 to oxygen or ubiquinone-2 via its (2Fe-2S) cluster.	Oxygen	172-178	CDGSH iron sulfur domain 1	Homo sapiens	62-70
15086960-2	2004	This reaction uses molecular oxygen and is catalyzed by chlorophyllide a oxygenase (CAO).	Oxygen	29-35	uncharacterized protein	Chlamydomonas reinhardtii	84-87
15075239-0	2004	Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.	Oxygen	0-6	RNA binding motif (RNP1, RRM) protein 3	Mus musculus	56-60
15075239-0	2004	Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.	Oxygen	0-6	cold inducible RNA binding protein	Mus musculus	65-69
15087715-5	2004	We detected AIF relocation from mitochondria to nucleus in primary cultured rat neurons 4 and 8 hours after 4 hours of oxygen/glucose deprivation.	Oxygen	119-125	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	12-15
12649278-0	2003	Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes.	Oxygen	37-43	solute carrier family 2 member 1	Homo sapiens	75-80
12742022-10	2003	It was therefore concluded that the tetrahedral geometry of gamma-phosphate (or its analogs) and the inter-atomic distance ( approximately 1.6A) between phosphorus (vanadium, or metal atom) and oxygen (or fluorine) are both important for inducing the allosteric transition of GroEL, leading to the high selectivity of GroEL for ATP about ligand adenine nucleotides, which function as the preferred allosteric ligand.	Oxygen	194-200	heat shock protein family D (Hsp60) member 1	Homo sapiens	276-281
12742022-10	2003	It was therefore concluded that the tetrahedral geometry of gamma-phosphate (or its analogs) and the inter-atomic distance ( approximately 1.6A) between phosphorus (vanadium, or metal atom) and oxygen (or fluorine) are both important for inducing the allosteric transition of GroEL, leading to the high selectivity of GroEL for ATP about ligand adenine nucleotides, which function as the preferred allosteric ligand.	Oxygen	194-200	heat shock protein family D (Hsp60) member 1	Homo sapiens	318-323
12777904-0	2003	Resuscitation with a novel hemoglobin-based oxygen carrier in a Swine model of uncontrolled perioperative hemorrhage.	Oxygen	44-50	HGB	Sus scrofa	27-37
12777904-1	2003	BACKGROUND: Systemic and pulmonary hypertension, possibly related to nitric oxide scavenging by free hemoglobin (Hb), is often seen during resuscitation with hemoglobin-based oxygen carriers (HBOCs).	Oxygen	175-181	HGB	Sus scrofa	101-111
12777904-1	2003	BACKGROUND: Systemic and pulmonary hypertension, possibly related to nitric oxide scavenging by free hemoglobin (Hb), is often seen during resuscitation with hemoglobin-based oxygen carriers (HBOCs).	Oxygen	175-181	HGB	Sus scrofa	158-168
15009686-11	2004	inosine is formed by an adenosine deaminase-dependent pathway during oxygen-glucose deprivation but not during 2-deoxyglucose treatment.	Oxygen	69-75	adenosine deaminase	Rattus norvegicus	24-43
35609862-12	2022	Because NADH oxidation is required for cellular glycolytic activity, we propose that the mitochondrial outer membrane protein mitoNEET may promote glycolysis by transferring electrons from FMNH2 to oxygen or ubiquinone-10 in mitochondria.	Oxygen	198-204	CDGSH iron sulfur domain 1	Homo sapiens	126-134
35636290-5	2022	After optimization of the molten salt mass, the CoP/Co/C-6 shows the best bifunctional performance, requiring an overpotential of 132 mV and 320 mV at 10 mA cm-2 for hydrogen evolution reaction and oxygen evolution reaction, respectively.	Oxygen	198-204	caspase recruitment domain family member 16	Homo sapiens	48-51
14995343-1	2004	We report the first direct observation of the oxygen-isotope ((16)O/(18)O) effect on the in-plane penetration depth lambda(ab) in a nearly optimally doped YBa(2)Cu(3)O(7-delta) film using the novel low-energy muon-spin rotation technique.	Oxygen	46-52	spindlin 1	Homo sapiens	214-218
12817626-3	2003	The aim of this study was to evaluate the effects of chronic exposure to low oxygen tension on the induction of inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) in rat heart.	Oxygen	77-83	heme oxygenase 1	Rattus norvegicus	155-171
12817626-3	2003	The aim of this study was to evaluate the effects of chronic exposure to low oxygen tension on the induction of inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) in rat heart.	Oxygen	77-83	heme oxygenase 1	Rattus norvegicus	173-177
35537709-4	2022	Thus, this study aimed to determine the CP location concerning anaerobic threshold, respiratory compensation point (RCP), and maximum oxygen uptake (VO2max).	Oxygen	134-140	ceruloplasmin	Homo sapiens	40-42
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	12-18	egl-9 family hypoxia inducible factor 3	Homo sapiens	78-82
12615973-3	2003	Three human oxygen-dependent HIF-1 alpha prolyl hydroxylases (PHD1, PHD2, and PHD3) function as oxygen sensors in vivo.	Oxygen	96-102	egl-9 family hypoxia inducible factor 3	Homo sapiens	78-82
14734109-1	2004	NADPH oxidase is an enzyme that catalyzes the production of superoxide from oxygen and NADPH.	Oxygen	76-82	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
35339646-3	2022	This study investigated the role and mechanism of Ski in the inflammatory response triggered by reactive astrocytes induced by oxygen and sugar deprivation/reoxygenation (OGD/R) model in vitro.	Oxygen	127-133	SKI proto-oncogene	Homo sapiens	50-53
14715679-4	2004	The beta2-AR genotype also was independently associated with a-vDO2 during submaximal (P = 0.004) and approximately 100% maximal O2 uptake exercise (P = 0.006), with a 1.2-2 ml/100 ml greater a-vDO2 in the Gln/Gln than in the Glu/Glu genotype women.	Oxygen	65-67	adrenoceptor beta 2	Homo sapiens	4-12
14980311-6	2004	RESULTS: : At 20% oxygen there was significantly reduced MMP-2 (P &lt; .05) and TIMP-1 (P &lt; .01) release and a trend for decreased MMP-9 release (P = .07) in explants from IUGR pregnancies compared with normal pregnancies; however, there were no differences at 3% oxygen.	Oxygen	18-24	matrix metallopeptidase 9	Homo sapiens	134-139
12777051-0	2003	Ferredoxin from sweet pepper (Capsicum annuum L.) intensifying harpin(pss)-mediated hypersensitive response shows an enhanced production of active oxygen species (AOS).	Oxygen	147-153	ferredoxin	Nicotiana tabacum	0-10
35524454-4	2022	Upon sono-irradiation, SPNAb generates 1 O2 not only to elicit sonodynamic effect to induce the immunogenic cell death, but also to release anti-CTLA-4 antibodies and trigger in situ checkpoint blockade.	Oxygen	41-43	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	145-151
14730659-9	2004	Similarly, maximal TA MCP-1, MCP-2, and MCP-3 but not MIP-1alpha and MIP-1beta concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks of postconceptional age (PCA) than those who were not oxygen-dependent at 36 weeks PCA.	Oxygen	140-146	C-C motif chemokine ligand 7	Homo sapiens	40-45
35633910-2	2022	Hypoxia inducible factor 1alpha (HIF-1alpha) is a key factor that regulates oxygen homeostasis and redox, and the stability of HIF-1alpha is related to the ROS level regulated by Sirtuin (Sirt) family.	Oxygen	76-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
14995391-0	2004	Spin-polarized electron scattering at single oxygen adsorbates on a magnetic surface.	Oxygen	45-51	spindlin 1	Homo sapiens	0-4
12754789-5	2003	The presence of different NO-hemoglobin derivatives can differently influence on the whole blood hemoglobin-oxygen affinity (HOA): methemoglobin and SNO-Hb increases, and HbFe2+NO decreases it.	Oxygen	108-114	hemoglobin subunit gamma 2	Homo sapiens	131-144
15636193-5	2004	After 2 months of nasal CPAP treatment, these patients had a lower breathing reserve and a greater increase in anaerobic threshold and oxygen pulse.	Oxygen	135-141	centromere protein J	Homo sapiens	24-28
15003365-3	2004	These data suggest that alpha-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release.	Oxygen	262-268	proopiomelanocortin	Rattus norvegicus	24-33
12490539-3	2003	Their regulation occurs through oxygen-dependent proteolysis of the alpha subunits HIF-1alpha and HIF-2alpha, respectively.	Oxygen	32-38	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	83-93
12490539-3	2003	Their regulation occurs through oxygen-dependent proteolysis of the alpha subunits HIF-1alpha and HIF-2alpha, respectively.	Oxygen	32-38	endothelial PAS domain protein 1	Rattus norvegicus	98-108
12540547-10	2003	Taken together, the impaired ability of the lon disruption mutant to survive and grow in macrophages could be due to the enhanced susceptibility to the oxygen-dependent killing mechanism associated with respiratory burst and the low phagosomal pH.	Oxygen	152-158	lon peptidase 1, mitochondrial	Mus musculus	44-47
35633910-2	2022	Hypoxia inducible factor 1alpha (HIF-1alpha) is a key factor that regulates oxygen homeostasis and redox, and the stability of HIF-1alpha is related to the ROS level regulated by Sirtuin (Sirt) family.	Oxygen	76-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
35563503-6	2022	Simultaneous measurements of oxygen consumption, membrane potential, NADH, and the ubiquinone redox state were correlated to ProDH activity and F1FO-ATPase directionality.	Oxygen	29-35	proline dehydrogenase	Mus musculus	125-130
15180271-0	2003	Quantitative PCR analysis of FosB mRNA expression after short duration oxygen and light stress.	Oxygen	71-77	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-33
15180271-1	2003	Quantitative polymerase chain reaction (QPCR) was used to examine changes in FosB mRNA expression in models of oxygen and light stress to the retina.	Oxygen	111-117	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-81
15058468-3	2004	By means of the overall mass-transfer coefficient (KLa), the transfer coefficient of hydrogen sulfide (KLa(H2S)), referring to total sulfide, was correlated to that of oxygen (KLa(O2)) (i.e., the reaeration coefficient).	Oxygen	168-174	immunoglobulin kappa variable 1D-39	Homo sapiens	176-182
35072619-2	2022	MATERIALS AND METHODS: The volume of oxygen uptake (VO2) at a respiratory exchange ratio equal to 1 (VO2(RER=1)) was measured during a graded cycling test, and the 6MWT distance was tested in 27 Chinese patients on MHD and 44 age-matched non-MHD subjects (CON).	Oxygen	37-43	retention in endoplasmic reticulum sorting receptor 1	Homo sapiens	105-110
14522958-0	2003	Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia.	Oxygen	81-87	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	38-43
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Oxygen	43-49	neuroglobin	Homo sapiens	0-11
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Oxygen	109-115	neuroglobin	Homo sapiens	0-11
12642970-4	2003	As seen from the fragment"s properties, active compounds are characterized by the presence of two atoms of oxygen, O1 and O3, which are situated at a distance of 13.5 A and possess high negative charges (-0.29 to -0.31 e).	Oxygen	107-113	immunoglobulin kappa variable 2D-40	Homo sapiens	115-124
35066234-4	2022	Herein, a facile in-situ photodeposition strategy has been developed to grow CdS nanocrystals on MnO2-x nanorods with rich oxygen vacancies (VO) as a direct Z-scheme photocatalyst for boosting water oxidation.	Oxygen	123-129	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
12559177-2	2003	pVHL targets the alpha subunits of hypoxia inducible factor (HIF) for ubiquitin-mediated degradation in an oxygen-dependent manner.	Oxygen	107-113	von Hippel-Lindau tumor suppressor	Mus musculus	0-4
12520415-0	2003	Effects of inhibition of neuronal nitric oxide synthase on NMDA-induced changes in cerebral blood flow and oxygen consumption.	Oxygen	107-113	nitric oxide synthase 1	Rattus norvegicus	25-55
14530264-6	2003	Mutation of the cysteines involved, or the use of reducing agents to break the S-S bond, led to a decrease in the observed oxygen affinity of human neuroglobin by an order of magnitude.	Oxygen	123-129	neuroglobin	Homo sapiens	148-159
14658884-3	2003	The Nb6Oi6Cli6Cla6 and Nb2(mu2-Cl)2Cl4O4 units form [Nb6Cli6Oi4O(i-i)(2/2)Cl(a-a)(4/2)Cla2]infinity infinite chains and [(Nb2(mu2-Cl)2O(2/2)Cl(4/2)O2)2]infinity double chains, respectively, that are interconnected by shared oxygen and chlorine ligands leading to layers.	Oxygen	224-230	contactin 5	Homo sapiens	23-26
12520415-1	2003	This study was performed to determine whether neuronal nitric oxide synthase (nNOS) is involved in altering regional cerebral blood flow (rCBF) and oxygen consumption during N-methyl- D-aspartate (NMDA) receptor stimulation.	Oxygen	148-154	nitric oxide synthase 1	Rattus norvegicus	46-76
35066234-7	2022	Owing to the synergistic effects of VO and Z-scheme systems, the optimized MnO2-x/CdS photocatalyst displays a dramatically enhanced photocatalytic activity with an O2 production rate of 779 mumol g-1h-1 under visible-light irradiation without any cocatalysts, which is 2.33 times higher than the bare MnO2-x.	Oxygen	165-167	CDP-diacylglycerol synthase 1	Homo sapiens	82-85
12520415-1	2003	This study was performed to determine whether neuronal nitric oxide synthase (nNOS) is involved in altering regional cerebral blood flow (rCBF) and oxygen consumption during N-methyl- D-aspartate (NMDA) receptor stimulation.	Oxygen	148-154	nitric oxide synthase 1	Rattus norvegicus	78-82
14597738-3	2003	Low oxygen concentration induces high expression of the CXCL12 receptor, CXC receptor 4 (CXCR4), in different cell types (monocytes, monocyte-derived macrophages, tumor-associated macrophages, endothelial cells, and cancer cells), which is paralleled by increased chemotactic responsiveness to its specific ligand.	Oxygen	4-10	C-X-C motif chemokine receptor 4	Homo sapiens	73-87
14597738-3	2003	Low oxygen concentration induces high expression of the CXCL12 receptor, CXC receptor 4 (CXCR4), in different cell types (monocytes, monocyte-derived macrophages, tumor-associated macrophages, endothelial cells, and cancer cells), which is paralleled by increased chemotactic responsiveness to its specific ligand.	Oxygen	4-10	C-X-C motif chemokine receptor 4	Homo sapiens	89-94
35603649-0	2022	(Activation of JNK induces apoptosis to autophagy conversion and enhances the survival of oxygen-glycogen deprived rat neurons).	Oxygen	90-96	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
14595184-13	2003	These results suggests that hyperbaric oxygen reduces the accumulation of leukocytes in the TRAM flap, but not enough to prevent adhesion of neutrophils on endothelial cells; ischemia-reperfusion injury increases the expression of CD18 and ICAM-1 and causes increased adhesion of leukocytes on the endothelium; hyperbaric oxygen does not alter the expression of CD18 but decreases the expression of ICAM-1; and the point of application for hyperbaric oxygen, whether applied before or after reperfusion, did not show any differences in outcome.	Oxygen	39-45	intercellular adhesion molecule 1	Rattus norvegicus	240-246
14595184-13	2003	These results suggests that hyperbaric oxygen reduces the accumulation of leukocytes in the TRAM flap, but not enough to prevent adhesion of neutrophils on endothelial cells; ischemia-reperfusion injury increases the expression of CD18 and ICAM-1 and causes increased adhesion of leukocytes on the endothelium; hyperbaric oxygen does not alter the expression of CD18 but decreases the expression of ICAM-1; and the point of application for hyperbaric oxygen, whether applied before or after reperfusion, did not show any differences in outcome.	Oxygen	39-45	intercellular adhesion molecule 1	Rattus norvegicus	399-405
14595184-14	2003	In conclusion, the application of hyperbaric oxygen against ischemia-reperfusion injury increases flap survival and the beneficial effect may be explained by a protective mechanism involving downregulation of ICAM-1 on endothelial cells.	Oxygen	45-51	intercellular adhesion molecule 1	Rattus norvegicus	209-215
14617264-0	2003	Maximum rate of oxygen consumption related to succinate dehydrogenase activity in skeletal muscle fibres of chronic heart failure patients and controls.	Oxygen	16-22	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	46-69
14617264-5	2003	VO2max (range: 29 ml O2 kg muscle(-1) min(-1) in a class III patient to 118 ml O2 kg muscle(-1) min(-1) in a control subject) correlates with the mean SDH activity of skeletal muscle fibres (r=0.79 or r=0.81, including or excluding oxygen uptake at rest, respectively; P&lt;0.001).	Oxygen	232-238	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	151-154
14617264-7	2003	From the product of SDH activity and the cross-sectional area of the fibre (i.e. spatially integrated SDH activity), it is possible to calculate the maximum oxygen uptake rate per unit muscle fibre length.	Oxygen	157-163	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	20-23
14617264-7	2003	From the product of SDH activity and the cross-sectional area of the fibre (i.e. spatially integrated SDH activity), it is possible to calculate the maximum oxygen uptake rate per unit muscle fibre length.	Oxygen	157-163	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	102-105
12525253-7	2003	Exposure of the oxygen-sensitive cell line PC-12 to hypoxia elicited an increase in AM mRNA expression and peptide secretion into serum-free conditioned medium.	Oxygen	16-22	adrenomedullin	Rattus norvegicus	84-86
12486248-3	2002	Plants overexpressing the Hb 1 protein, mutated to have a low oxygen affinity, are as susceptible to hypoxia as WT plants, suggesting that the protection against hypoxia depends on the ability of the Hb to bind ligands, such as oxygen, with high affinity.	Oxygen	62-68	hemoglobin 1	Arabidopsis thaliana	26-30
12486248-3	2002	Plants overexpressing the Hb 1 protein, mutated to have a low oxygen affinity, are as susceptible to hypoxia as WT plants, suggesting that the protection against hypoxia depends on the ability of the Hb to bind ligands, such as oxygen, with high affinity.	Oxygen	228-234	hemoglobin 1	Arabidopsis thaliana	26-30
12468029-2	2002	FBP (3.5 mM) reduced delayed death from oxygen/glucose deprivation in CA1, CA3 and dentate neurons in slice cultures.	Oxygen	40-46	fructose-bisphosphatase 1	Homo sapiens	0-3
12468029-2	2002	FBP (3.5 mM) reduced delayed death from oxygen/glucose deprivation in CA1, CA3 and dentate neurons in slice cultures.	Oxygen	40-46	carbonic anhydrase 1	Homo sapiens	70-73
35624752-2	2022	In this study, we established a topography of hypoxia in the visual pathway by inducing OHT in mice that express a fusion protein comprised of the oxygen-dependent degradation (ODD) domain of HIF-1alpha and a tamoxifen-inducible Cre recombinase (CreERT2) driven by a ubiquitous CAG promoter.	Oxygen	147-153	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-202
12450933-10	2002	Furthermore, DS-1 reduced venous admixture and improved arterial oxygen saturation.	Oxygen	65-71	mitochondrial ribosomal protein L58	Homo sapiens	13-17
14600837-6	2003	HIF-1alpha subunit is continuously synthesized and degraded under normoxic conditions, while it accumulates rapidly following exposure to low oxygen tensions.	Oxygen	142-148	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
14600837-7	2003	Hydroxylation of HIF-1alpha by prolyl hydroxylase for proteasomal degradation was dependent on iron, 2-oxoglutarate, and oxygen concentration.	Oxygen	121-127	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	17-27
35461826-9	2022	Mitochondrial dysfunction due to ERRgamma deletion further triggers autophagy dysfunction, ER stress, and production of reactive oxygen species, ultimately leading to cell death.	Oxygen	129-135	estrogen-related receptor gamma	Mus musculus	33-41
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	104-110	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	49-52
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	149-180
12413864-3	2002	The investigations on the specificity for transacetylase (TA) with respect to the number and positions of acetoxy groups on the benzenoid ring of coumarin molecule revealed that acetoxy groups in proximity to the oxygen heteroatom (at C-7 and C-8 positions) demonstrate a high degree of specificity to TA.	Oxygen	213-219	complement C7	Homo sapiens	235-238
12516960-7	2002	In vitro, ET-2, ET-RA, and ET-RB mRNA were increased by incubating HTH-K cells in hypoxia (0.1% oxygen) for 24 h. Hypoxia also up-regulated ET-2 mRNA in several human breast tumor cell lines.	Oxygen	96-102	endothelin 2	Homo sapiens	10-14
12876291-2	2003	Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha).	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	182-192
35530276-8	2022	HECTD1 mRNA expression was inversely associated with mitochondrial cellular respiratory function (oxidative phosphorylation (P<0.001, FDR q-value <0.001) the respiratory chain complex (P<0.001, FDR q-value <0.001) and reactive oxygen species (P<0.001, FDR q-value <0.001), but not with epithelial-mesenchymal transition, in breast cancer tissues.	Oxygen	227-233	HECT domain E3 ubiquitin protein ligase 1	Homo sapiens	0-6
12730074-6	2003	After hyperoxic exposure, L-selectin did not differ between the exposure groups but soluble L-selectin tended to increase in neonates after 7 d of O2 exposure Finally, CD18 was significantly higher after hyperoxic exposure of the adult (P = 0.008), but did not change with oxygen exposure in the neonate.	Oxygen	147-149	selectin L	Rattus norvegicus	92-102
12730074-7	2003	Based on these findings, we speculate that differences between neonatal and adult rats in expression of L-selectin may contribute to delayed oxygen toxicity in neonatal rats.	Oxygen	141-147	selectin L	Rattus norvegicus	104-114
12860983-1	2003	Neuroglobin (Ngb) is a newly discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen.	Oxygen	119-125	neuroglobin	Homo sapiens	0-11
12213810-4	2002	The most dramatic loss of antigenicity was seen with the 17-kDa glycine decarboxylase complex (GDC) H-protein, which was correlated with the loss of glycine-dependent O2 consumption.	Oxygen	167-169	myosin binding protein H	Homo sapiens	100-109
12508771-0	2002	VEGF release is associated with reduced oxygen tensions in experimental inflammatory arthritis.	Oxygen	40-46	vascular endothelial growth factor A	Mus musculus	0-4
35453645-6	2022	The administration of rKL protein inhibited the expression of pro-inflammatory cytokines in the peri-infarct regions and significantly attenuated apoptosis and production of intracellular reactive oxygen species by myocardial I/R injury.	Oxygen	197-203	Klotho	Rattus norvegicus	22-25
12470895-1	2002	Oxidative damage shortens the life span of the nematode Caenorhabditis elegans (C. elegans), even in an age-1 mutant that is characterized by a long life and oxygen resistance.	Oxygen	158-164	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	104-109
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Oxygen	0-6	E1A binding protein p300	Mus musculus	167-171
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Oxygen	0-6	CREB binding protein	Mus musculus	172-175
12866028-8	2003	Of interest, only the EMT6 cell line was able to secrete the proangiogenic molecule, vascular endothelial growth factor (VEGF), in response to low oxygen conditions.	Oxygen	147-153	vascular endothelial growth factor A	Mus musculus	85-119
12866028-8	2003	Of interest, only the EMT6 cell line was able to secrete the proangiogenic molecule, vascular endothelial growth factor (VEGF), in response to low oxygen conditions.	Oxygen	147-153	vascular endothelial growth factor A	Mus musculus	121-125
12951059-2	2003	We evaluated the effect of hyperbaric oxygen (HBO) on the expression of Nogo-A, Ng-R, and RhoA after transient global ischemia in a rat 2 vessel occlusion global ischemic model.	Oxygen	38-44	reticulon 4	Rattus norvegicus	72-78
12368211-0	2002	Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).	Oxygen	25-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	92-95
12951059-2	2003	We evaluated the effect of hyperbaric oxygen (HBO) on the expression of Nogo-A, Ng-R, and RhoA after transient global ischemia in a rat 2 vessel occlusion global ischemic model.	Oxygen	38-44	ras homolog family member A	Rattus norvegicus	90-94
12368211-0	2002	Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).	Oxygen	25-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	96-100
35393829-10	2022	At the same time, when the average gas velocity increased by 0.1 m s-1, the lengths of pipes where dissolved oxygen could effectively inhibit H2S increased by 25 m.	Oxygen	109-115	gastrin	Homo sapiens	35-38
12368211-0	2002	Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).	Oxygen	25-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	101-105
12368211-0	2002	Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).	Oxygen	25-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	106-110
35143076-8	2022	Both in vitro and in vivo results demonstrate that PBzyme reduces the activation of microglial NLRP3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating GSDMD cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis.	Oxygen	152-158	NLR family, pyrin domain containing 3	Mus musculus	95-100
12368211-11	2002	These results reveal that p21 is required for remodeling the oxygen-injured lung and suggest that failure to limit replication of damaged DNA may lead to cell death, inflammation, and abnormal remodeling.	Oxygen	61-67	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	26-29
12970193-2	2003	By radiolabelling of yeast cells with 55Fe we demonstrate that Isu1p binds an oxygen-resistant non-chelatable Fe/S cluster providing in vivo evidence for a scaffolding function of Isu1p during Fe/S cluster assembly.	Oxygen	78-84	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	63-68
12970193-2	2003	By radiolabelling of yeast cells with 55Fe we demonstrate that Isu1p binds an oxygen-resistant non-chelatable Fe/S cluster providing in vivo evidence for a scaffolding function of Isu1p during Fe/S cluster assembly.	Oxygen	78-84	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	180-185
35485210-9	2022	Moreover, LINC01606 protected colon cancer cells from ferroptosis by decreasing the concentration of iron, lipid reactive oxygen species, mitochondrial superoxide and increasing mitochondrial membrane potential.	Oxygen	122-128	long intergenic non-protein coding RNA 1606	Homo sapiens	10-19
12972896-6	2003	Moreover, the arterial oxygen tension to inspired oxygen concentration ratio and tidal volume were improved at the end of the 30 min Boussignac-CPAP period compared with baseline.	Oxygen	23-29	centromere protein J	Homo sapiens	144-148
12972896-6	2003	Moreover, the arterial oxygen tension to inspired oxygen concentration ratio and tidal volume were improved at the end of the 30 min Boussignac-CPAP period compared with baseline.	Oxygen	50-56	centromere protein J	Homo sapiens	144-148
12356842-0	2002	Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy.	Oxygen	50-56	PCNA clamp associated factor	Rattus norvegicus	0-26
12356842-7	2002	Exposure to 80% O(2) induced retinal vasoobliteration, which was equally significantly inhibited ( approximately 60%) by all PAF receptor blockers tested.	Oxygen	16-20	PCNA clamp associated factor	Rattus norvegicus	125-128
12242281-7	2002	Studies with GAL4-HIF-1alpha fusion proteins pinpointed the oxygen-dependent degradation domain as a critical target for the rapamycin-sensitive, mTOR-dependent signaling pathway leading to HIF-1alpha stabilization by CoCl(2).	Oxygen	60-66	galectin 4	Homo sapiens	13-17
35319792-5	2022	Adding beta-lactolin to Abeta-treated HT22 cells increased both the oxygen consumption rate and cellular ATP concentrations, suggesting that beta-lactolin improves mitochondrial respiration and energy production.	Oxygen	68-74	amyloid beta (A4) precursor protein	Mus musculus	24-29
12410458-1	2002	PURPOSE: The objective of this trial was to compare the effectiveness of intraarticular injection of highly cross-linked hyaluronic acid (HA) with intraarticular injection of gaseous oxygen (O 2 ) in patients with clinical symptoms of cartilage damage in the knee.	Oxygen	183-189	immunoglobulin kappa variable 1D-39	Homo sapiens	191-194
14658188-4	2003	RESULT: The mean minimum oxygen saturation of 51 patients received preoperative CPAP treatment was increased from (63.54 +/- 9.45)% to (83.32 +/- 8.85)% (t = 11.52, P &lt; 0.01), and only one of them underwent tracheotomy because of severe fat.	Oxygen	25-31	centromere protein J	Homo sapiens	80-84
12873954-12	2003	In organotypic cultures of rat hippocampus, we show that protection of CA1, CA3, and dentate neurons by 1% isoflurane from death caused by oxygen and glucose deprivation involves GABA(A) receptors.	Oxygen	139-145	carbonic anhydrase 3	Rattus norvegicus	76-79
34472482-5	2022	Our results revealed that in oxygen and glucose deprivation/reoxygenation-treated HT22 cells, MEG3 expression was obviously upregulated, and autophagy was increased, while knockdown of MEG3 expression greatly reduced autophagy.	Oxygen	29-35	maternally expressed 3	Mus musculus	94-98
12237227-4	2002	Because H(4)B provides this electron faster than can the NOS reductase domain, H(4)B appears to be a kinetically preferred source of the second electron for oxygen activation during Arg hydroxylation.	Oxygen	157-163	H4 clustered histone 4	Homo sapiens	8-13
12237227-4	2002	Because H(4)B provides this electron faster than can the NOS reductase domain, H(4)B appears to be a kinetically preferred source of the second electron for oxygen activation during Arg hydroxylation.	Oxygen	157-163	H4 clustered histone 4	Homo sapiens	79-84
12207919-4	2002	Investigation of its ability to support O(2)(-)-generation in cell-free reconstitution experiments combining with neutrophil cytochrome b(558) showed O(2)(-)-generation, provided that recombinant p47(phox) was added.	Oxygen	150-154	mitochondrially encoded cytochrome b	Homo sapiens	125-137
12067761-0	2002	Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils.	Oxygen	11-17	integrin subunit alpha M	Homo sapiens	47-52
12921756-1	2003	The effects of hyperbaric oxygen (HBO(2)) therapy on the immune system are reported including potential changes to the CD4/CD8 ratio and a decreased proliferation of lymphocytes during exposure.	Oxygen	26-32	CD4 antigen	Mus musculus	119-122
12811540-3	2003	Because chronic hypoxic stimulation at high altitudes causes sporadic CB paragangliomas, it has been hypothesized that the SDHD gene product may be involved in oxygen sensing.	Oxygen	160-166	succinate dehydrogenase complex subunit D	Homo sapiens	123-127
12811540-12	2003	Collectively, these data suggest that higher altitudes and nonsense/splicing mutations are associated with phenotypic severity in PGL1 and support the hypothesis that SDHD mutations impair oxygen sensing.	Oxygen	189-195	succinate dehydrogenase complex subunit D	Homo sapiens	167-171
34472482-5	2022	Our results revealed that in oxygen and glucose deprivation/reoxygenation-treated HT22 cells, MEG3 expression was obviously upregulated, and autophagy was increased, while knockdown of MEG3 expression greatly reduced autophagy.	Oxygen	29-35	maternally expressed 3	Mus musculus	185-189
34472482-7	2022	Further experiments revealed that mir-181c-5p overexpression reversed the effect of MEG3 on autophagy and ATG7 expression in HT22 cells subjected to oxygen and glucose deprivation/reoxygenation.	Oxygen	149-155	maternally expressed 3	Mus musculus	84-88
12124847-3	2002	Spectrophotometric and dissolved oxygen studies indicate that tyrosinase can oxidize gelatin and we estimate that 1 in 5 gelatin chains undergo reaction.	Oxygen	33-39	tyrosinase	Homo sapiens	62-72
35361857-8	2022	Both apoA1 transduction conditions similarly inhibited basal and TNFalpha-induced reactive oxygen species in rat aortic endothelial cells (RAEC) and resulted in the reduced rat monocyte attachment to the TNFalpha-activated endothelium.	Oxygen	91-97	apolipoprotein A1	Rattus norvegicus	5-10
12226811-7	2002	Hypoxia-inducible factor 1alpha can be demonstrated by immunohistochemistry in cardiomyocytes with high PO(2,crit) and increased spatially integrated succinate dehydrogenase activity, indicating that limited oxygen supply affects gene expression in these cells.	Oxygen	208-214	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
12121862-2	2002	During 8 days of culture under 5% O(2), but not room air, the addition of VEGF to explants stimulated the formation of CD31-positive, Flk-1-positive, Gs-IB(4)-positive structures in a concentration-dependent manner.	Oxygen	34-38	vascular endothelial growth factor A	Mus musculus	74-78
12900688-8	2003	Altering the software changed the pooled %O(2) from 16.24 +/- 0.40% for the CPX/D to 16.04 +/- 0.39% for the CPX/DDelta, and these were significantly different than pooled data for the FU system (16.15 +/- 0.39%).	Oxygen	42-46	EBP cholestenol delta-isomerase	Homo sapiens	76-79
12900688-8	2003	Altering the software changed the pooled %O(2) from 16.24 +/- 0.40% for the CPX/D to 16.04 +/- 0.39% for the CPX/DDelta, and these were significantly different than pooled data for the FU system (16.15 +/- 0.39%).	Oxygen	42-46	EBP cholestenol delta-isomerase	Homo sapiens	109-112
12720088-6	2003	BALB/c mouse sera raised against the adult 17 kDa protein revealed that this myoglobin was distributed throughout the parenchymal tissues except for the eggs and reproductive organs and that the protein may be involved in the survival of C. sinensis in the oxygen-depleted environment of the host.	Oxygen	257-263	myoglobin	Mus musculus	77-86
12121862-6	2002	Our data suggest that low O(2) upregulates Flk-1 expression in embryonic aorta in vitro and renders it more responsive to VEGF.	Oxygen	26-30	vascular endothelial growth factor A	Mus musculus	122-126
35351847-4	2022	Further studies suggest that the production of covalent bonds between CA and CDs plays pivotal roles in activating LPL and preventing its quenching from oxygen and water.	Oxygen	153-159	lipoprotein lipase	Homo sapiens	115-118
12230870-2	2002	The molecular pathways that regulate ho-1 gene expression under hypoxia may involve mitogen activated protein kinase (MAPK) signaling and reactive oxygen.	Oxygen	147-153	heme oxygenase 1	Rattus norvegicus	37-41
12897258-7	2003	Proteome differences in ppi1 could be correlated with protein import rates: ppi1 chloroplasts imported the ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit and 33-kD oxygen-evolving complex precursors at significantly reduced rates, but the import of a 50S ribosomal subunit precursor was largely unaffected.	Oxygen	145-151	proton pump interactor 1	Arabidopsis thaliana	24-28
12897258-7	2003	Proteome differences in ppi1 could be correlated with protein import rates: ppi1 chloroplasts imported the ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit and 33-kD oxygen-evolving complex precursors at significantly reduced rates, but the import of a 50S ribosomal subunit precursor was largely unaffected.	Oxygen	145-151	proton pump interactor 1	Arabidopsis thaliana	76-80
35408505-5	2022	The experiments herein describe an anticancer mechanism in which heat shock protein 90 (HSP90) stabilizes HIF-1alpha, a master transcription factor of oxygen homeostasis that has been implicated in the survival, proliferation and malignant progression of cancers.	Oxygen	151-157	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-86
12868878-3	2003	These [4 + 2] cycloadditions proceed with a strong kinetic bias for bonding to the dienophile from the direction syn to the tetrahydrofuranyl oxygen and consequently hold value in stereoselective synthesis.	Oxygen	142-148	synemin	Homo sapiens	113-116
12358792-5	2002	We used brain tissue of a temperate bat Rhinolopus ferrumequinum to investigate GRP induction by high metabolic oxygen demand and to identify associated signaling molecules.	Oxygen	112-118	gastrin releasing peptide	Homo sapiens	80-83
12238906-6	2002	During Period 2, the smallest survival was a female infant with GA of 21 weeks and BW of 460 gm who was discharged with home oxygen therapy.	Oxygen	125-131	period circadian regulator 2	Homo sapiens	7-15
12840058-0	2003	Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity.	Oxygen	42-48	FMS-like tyrosine kinase 1	Mus musculus	25-32
35408505-5	2022	The experiments herein describe an anticancer mechanism in which heat shock protein 90 (HSP90) stabilizes HIF-1alpha, a master transcription factor of oxygen homeostasis that has been implicated in the survival, proliferation and malignant progression of cancers.	Oxygen	151-157	heat shock protein 90 alpha family class A member 1	Homo sapiens	88-93
12840058-1	2003	Oxygen administration to immature neonates suppresses VEGF-A expression in the retina, resulting in the catastrophic vessel loss that initiates retinopathy of prematurity.	Oxygen	0-6	vascular endothelial growth factor A	Mus musculus	54-60
12840058-11	2003	We conclude that VEGFR-1 is critical in maintaining the vasculature of the neonatal retina, and that activation of VEGFR-1 by PlGF-1 is a selective strategy for preventing oxygen-induced retinal ischemia without provoking retinal neovascularization.	Oxygen	172-178	FMS-like tyrosine kinase 1	Mus musculus	115-122
35305635-12	2022	Upregulation of cellular response to reactive oxygen species and inhibition of DNA repair mechanisms resulted after metformin and GS administration in MDA-MB-231 cell lines and metformin-treated MCF-7 cells.	Oxygen	46-52	SAFB like transcription modulator	Homo sapiens	116-125
12686560-10	2003	Fluorescence experiments revealed that Trp-32 was further oxidized by CO3., forming kynurenine-type products in the presence of oxygen.	Oxygen	128-134	thioredoxin like 1	Homo sapiens	39-45
12686560-11	2003	Molecular oxygen was needed for HCO3-/H2O2-dependent aggregation of hSOD1WT, implicating a role for a Trp-32-dependent peroxidative reaction in the covalent aggregation of hSOD1WT.	Oxygen	10-16	thioredoxin like 1	Homo sapiens	102-108
12809498-12	2003	We show by spin-trap electron-paramagnetic resonance that the light-induced singlet-oxygen formation of WSCP-bound Chl is lower by a factor of about 4 than that of unbound Chl.	Oxygen	84-90	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	104-108
12783038-10	2003	In SHC, but not in NHC and CON, net oxygen cost of cycling increased significantly (P &lt; 0.05) when cadence was increased from 36 to 76 rpm.	Oxygen	36-42	SHC adaptor protein 1	Homo sapiens	3-6
12783038-11	2003	CONCLUSION: At the age of 6-12 yr, SHC have a higher oxygen cost of cycling in exercise tasks requiring high velocity, which might be explained-at least in part-by an impaired neural control of intra- and intermuscular coordination.	Oxygen	53-59	SHC adaptor protein 1	Homo sapiens	35-38
12031856-12	2002	Thus IL-10 counteracts acute effects of endotoxin on cerebral metabolism, microcirculation and oxygen tension during hypoxia-ischemia in the perinatal brain.	Oxygen	95-101	interleukin 10	Homo sapiens	5-10
12037012-0	2002	Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP.	Oxygen	65-71	vascular endothelial growth factor A	Mus musculus	34-38
12037012-12	2002	CONCLUSIONS: Estrogen may function as a significant modulator of the level of VEGF mRNA under different oxygen conditions and could serve as a prophylactic agent for ROP.	Oxygen	104-110	vascular endothelial growth factor A	Mus musculus	78-82
12040027-13	2002	This provides intriguing evidence that permissive effects of O2/reactive oxygen species on cAMP regulation of SP-A expression may be mediated by cooperative interactions of TTF-1 and NF-kappaB at the TBE.	Oxygen	61-63	surfactant protein A2	Homo sapiens	110-114
12019610-16	2002	In conclusion, dEB changed blood oxygen content and pH, and influenced the acid-base buffer system in pigs.	Oxygen	33-39	DebC	Drosophila melanogaster	15-18
34995837-1	2022	d-Serine biosensing has been extensively reported based on enzyme sensors using flavin adenine dinucleotide (FAD) -dependent d-amino acid oxidase (DAAOx), based on the monitoring of hydrogen peroxide generated by the enzymatic reaction, which is affected by dissolved oxygen concentration in the measurement environment in in vivo use.	Oxygen	268-274	D-amino acid oxidase	Homo sapiens	147-152
11920687-5	2002	In mice with oxygen-induced ischemic retinopathy, deficiency of eNOS, but not iNOS or nNOS caused a significant decrease in retinal neovascularization and decreased expression of VEGF.	Oxygen	13-19	vascular endothelial growth factor A	Mus musculus	179-183
12757936-7	2003	There was a spontaneous, time-dependent increase of amino acid transporter B(0) mRNA in vehicle, which was suppressed by 2% oxygen and by forskolin treatment in 20% oxygen.	Oxygen	124-130	solute carrier family 6 member 14	Homo sapiens	52-79
12757936-7	2003	There was a spontaneous, time-dependent increase of amino acid transporter B(0) mRNA in vehicle, which was suppressed by 2% oxygen and by forskolin treatment in 20% oxygen.	Oxygen	165-171	solute carrier family 6 member 14	Homo sapiens	52-79
12756430-1	2003	Methemoglobinemia, an increased concentration of methemoglobin in the blood, is an altered state of hemoglobin whereby the ferrous form of iron is oxidized to the ferric state, rendering the heme moiety incapable of carrying oxygen.	Oxygen	225-231	hemoglobin subunit gamma 2	Homo sapiens	49-62
35424823-1	2022	An efficient synthesis of imides using metal-free photoredox-catalyzed direct alpha-oxygenation of N,N"-disubstituted anilines in the presence of 9-mesityl-10-methylacridinium (Acr+-Mes)BF4 as a photoredox catalyst and molecular oxygen as a green oxidant under visible light was developed.	Oxygen	229-235	acrosin	Homo sapiens	177-180
12894587-10	2003	Finally LMP-1 induces expression of Hypoxia-Inducible Factor-1 alpha (HIF-1 alpha), which mediates adaptation of cells to O2-depleted states.	Oxygen	122-124	PDZ and LIM domain 7	Homo sapiens	8-13
12018887-3	2002	One-electron acceptor, potassium ferricyanide, highly stimulated the rate of GP-dependent antimycin A-insensitive oxygen uptake, which was prevented by inhibitors of mitochondrial GP dehydrogenase (mGPDH) or by coenzyme Q (CoQ).	Oxygen	114-120	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	198-203
11890791-0	2002	Spin surface crossing in chromium-mediated olefin epoxidation with O(2).	Oxygen	67-71	spindlin 1	Homo sapiens	0-4
35194631-4	2022	Through systematic comparison, this allowed unambiguous radical identification and spectral assignment by experiment in all cases: NR3 is preferred over NR4", all other NRx are negligible; NR3 and NR4" are deprotonated at oxygens 4" and 3", respectively, unless barred by substitution, or at oxygen 7.	Oxygen	222-229	interleukin 13 receptor subunit alpha 1	Homo sapiens	197-200
12705823-7	2003	The results show that the expected stoichiometric proton consumption of 4H(+) in the reduction of O(2) to 2H(2)O is differently associated, depending on the actual pH, with the oxidation and reduction phase of COX.	Oxygen	98-102	cytochrome c oxidase subunit 7A1	Bos taurus	210-213
12705823-8	2003	Two H(+)/COX are initially taken up in the reduction of O(2) to two OH(-) groups bound to the binuclear Fe a(3)-Cu(B) center.	Oxygen	56-60	cytochrome c oxidase subunit 7A1	Bos taurus	9-12
35236967-0	2022	PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production.	Oxygen	94-100	AT-rich interaction domain 1A	Homo sapiens	49-55
12693934-6	2003	Addition of catalase to the Cu-S100B reaction with catechols reduces the amount of oxygen consumed by 50%, demonstrating that peroxide is released during this reaction.	Oxygen	83-89	S100 calcium binding protein B	Bos taurus	31-36
11879793-7	2002	That is, the intracerebroventricular injection of 1.0 microg of UCN in male Wistar rats (n=10) significantly increased whole body oxygen consumption compared to PBS control.	Oxygen	130-136	urocortin	Rattus norvegicus	64-67
11879793-9	2002	These studies suggest that UCN acutely increased whole body oxygen consumption and body temperature via central activation of sympathetic outflow.	Oxygen	60-66	urocortin	Rattus norvegicus	27-30
11855848-0	2002	Mga2p is a putative sensor for low temperature and oxygen to induce OLE1 transcription in Saccharomyces cerevisiae.	Oxygen	51-57	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	68-72
12529178-3	2003	We suggest that the primary target sites in Photosystem II for copper is tyrosine(z), both cytochrome b (559) forms and chlorophyll(z), and that these sites are the source of the copper-induced fluorescence quenching and oxygen evolution inhibition in Photosystem II.	Oxygen	221-227	mitochondrially encoded cytochrome b	Homo sapiens	91-103
35236967-6	2022	We find that ARID1A knock-out (KO) cells have an unusual mitochondrial phenotype with aberrant biogenesis, increased oxygen consumption/expression of oxidative phosphorylation genes, but without increased ATP production.	Oxygen	117-123	AT-rich interaction domain 1A	Homo sapiens	13-19
35236967-8	2022	Inhibition of PLK1 in ARID1A KO cells further uncouples oxygen consumption from ATP production, with subsequent membrane depolarization and apoptosis.	Oxygen	56-62	AT-rich interaction domain 1A	Homo sapiens	22-28
12854870-19	2003	Methemoglobin-forming agents are potent, but due to the transformation of hemoglobin into methemoglobin, they impair tissue delivery of oxygen.	Oxygen	136-142	hemoglobin subunit gamma 2	Homo sapiens	0-13
12854870-19	2003	Methemoglobin-forming agents are potent, but due to the transformation of hemoglobin into methemoglobin, they impair tissue delivery of oxygen.	Oxygen	136-142	hemoglobin subunit gamma 2	Homo sapiens	90-103
11846651-5	2002	The enhanced and accelerated syn-to-oxygen addition in lithium perchlorate in nitromethane is interpreted as a consequence of the coordination of Li+ to both the acetal oxygen and a heteroatom in the dienophile that brings them in close proximity to facilitate a reaction.	Oxygen	169-175	synemin	Homo sapiens	29-32
11846651-6	2002	The Li+-oxygen combination, however, also exerts some steric effect that results in reduced syn-to-oxygen addition of dienophiles having large substituents such as N-phenylmaleimide.	Oxygen	8-14	synemin	Homo sapiens	92-95
11846651-6	2002	The Li+-oxygen combination, however, also exerts some steric effect that results in reduced syn-to-oxygen addition of dienophiles having large substituents such as N-phenylmaleimide.	Oxygen	99-105	synemin	Homo sapiens	92-95
35203362-7	2022	Notably, the involvement of S1P axis in Adn action was highlighted since, when SK1 and 2 were inhibited by PF543 and ABC294640 inhibitors, respectively, not only the electrophysiological changes but also the increase of oxygen consumption and of aminoacid levels induced by the hormone, were significantly inhibited.	Oxygen	220-226	sphingosine kinase 1	Homo sapiens	79-88
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Oxygen	174-180	uncharacterized protein	Chlamydomonas reinhardtii	36-40
11842150-9	2002	A Crr1-independent pathway for Hyd1 expression in oxygen-depleted C. reinhardtii demonstrates the existence of multiple oxygen/redox-responsive circuits in this model organism.	Oxygen	50-56	uncharacterized protein	Chlamydomonas reinhardtii	2-6
11842150-9	2002	A Crr1-independent pathway for Hyd1 expression in oxygen-depleted C. reinhardtii demonstrates the existence of multiple oxygen/redox-responsive circuits in this model organism.	Oxygen	50-56	uncharacterized protein	Chlamydomonas reinhardtii	31-35
11842150-9	2002	A Crr1-independent pathway for Hyd1 expression in oxygen-depleted C. reinhardtii demonstrates the existence of multiple oxygen/redox-responsive circuits in this model organism.	Oxygen	120-126	uncharacterized protein	Chlamydomonas reinhardtii	2-6
11842150-9	2002	A Crr1-independent pathway for Hyd1 expression in oxygen-depleted C. reinhardtii demonstrates the existence of multiple oxygen/redox-responsive circuits in this model organism.	Oxygen	120-126	uncharacterized protein	Chlamydomonas reinhardtii	31-35
12612206-11	2003	BAL SP-D concentrations were significantly lower on d 2 and 3 among infants in supplemental oxygen on d 28 compared with those in air.	Oxygen	92-98	surfactant protein D	Homo sapiens	4-8
35108516-2	2022	Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O2 delivery by promoting bisphosphoglycerate mutase proteostasis and the Rapoport-Luebering glycolytic shunt for adaptation to hypoxia, in healthy humans ascending to high altitude and in two distinct murine models of hypoxia.	Oxygen	95-97	bisphosphoglycerate mutase	Homo sapiens	120-146
12691675-2	2003	Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle.	Oxygen	91-97	myoglobin	Mus musculus	73-75
11805327-3	2002	We have demonstrated a dramatic increase in the angiogenic response to oxygen-induced retinal ischemia in transgenic mice overexpressing PKC beta 2 isoform and a significant decrease in retinal neovascularization in PKC beta isoform null mice.	Oxygen	71-77	hemoglobin, beta adult minor chain	Mus musculus	141-147
34984586-6	2022	Here, Cav-1 protein expression after ischemic conditions, with or without rt-PA administration, was analyzed in a murine thromboembolic middle cerebral artery occlusion (MCAO) and in brain microvascular endothelial bEnd.3 cells subjected to oxygen/glucose deprivation (OGD).	Oxygen	241-247	caveolin 1, caveolae protein	Mus musculus	6-11
12404359-2	2001	Oxygen intermediates have been studied in detail for the proteins and enzymes involved in reversible O(2) binding (hemocyanin), activation (tyrosinase), and four-electron reduction to water (multicopper oxidases).	Oxygen	0-6	tyrosinase	Homo sapiens	140-150
12650847-7	2003	We conclude that impairment of reactive oxygen intermediates production, through scavenging reactive oxygen intermediates by baicalin, or antagonizing ligand-initiated Ca(2+) influx by baicalein, accounts for the inhibition of Mac-1-dependent leukocyte adhesion that confers the anti-inflammatory activity of baicalin or baicalein.	Oxygen	40-46	integrin subunit alpha M	Homo sapiens	227-232
35163456-3	2022	We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear.	Oxygen	80-86	hypoxia-inducible factor 1, alpha subunit inhibitor	Mus musculus	117-120
12633750-8	2003	This is followed by oxygen transfer to the most electropositive carbon atoms, C-6, C-1, and C-3, with formation of 6-OHBP (and its quinones), 1-OHBP, and 3-OHBP, respectively, or the most electropositive 4,5-, 7,8-, and 9,10- double bonds, with formation of BP 4,5-, 7,8-, or 9,10-oxide.	Oxygen	20-26	complement C3	Rattus norvegicus	92-95
12615064-4	2003	Our results show that S-nitrosation significantly increases the oxygen affinity of the adult Hb (HbA) with respect to native protein (no-nitrosated) while the functional properties of HbF are less influenced.	Oxygen	64-70	keratin 90, pseudogene	Homo sapiens	97-100
11860493-5	2001	The regional localization of HIF-1alpha mRNA and protein was determined by in situ hybridization and immunocytochemistry in adult male rats exposed to moderate hypoxia (10% O2) for 1-6 h. HIF-1alpha protein was found in cell types identified by immunocytochemistry as catecholaminergic neurons.	Oxygen	173-175	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	29-39
12615064-5	2003	The oxygen affinity modification, found for SNO-HbA, was ascribed to the nitrosation of cysteine beta 93: really, the same residue is also present in the gamma chains of fetal hemoglobin, while the increase of affinity is less evidenced; hence, it is probable that the 39 aminoacidic substitutions between beta and gamma chains allay the effects of S-nitrosation.	Oxygen	4-10	keratin 90, pseudogene	Homo sapiens	48-51
34982539-1	2022	delta-Bi2O3:M (M = S, Se, and Re) with an oxygen-defective fluorite-type structure is obtained by a coprecipitation method starting from the bismuth oxido cluster (Bi38O45(OMc)24(dmso)9) 2dmso 7H2O (A) in the presence of additives such as Na2SO4, Na2SeO4, NH4ReO4, Na2SeO3 5H2O, and Na2SO3.	Oxygen	42-48	squalene epoxidase	Homo sapiens	22-24
11735081-5	2001	Maximal O2 consumption was lower in ADRB2 Glu27Glu than in ADRB2 Glu27Gln and Gln27Gln genotype women (25.4 +/- 1.1 v 32.4 +/- 1.5 and 29.1 +/- 1.7 mL/kg/min, P &lt;.05).	Oxygen	8-10	adrenoceptor beta 2	Homo sapiens	36-41
11735081-5	2001	Maximal O2 consumption was lower in ADRB2 Glu27Glu than in ADRB2 Glu27Gln and Gln27Gln genotype women (25.4 +/- 1.1 v 32.4 +/- 1.5 and 29.1 +/- 1.7 mL/kg/min, P &lt;.05).	Oxygen	8-10	adrenoceptor beta 2	Homo sapiens	59-64
12617670-8	2003	Solvent-induced topological isomerism of these 3-D hydrogen-bonded networks of 1 arises from (i) the guest inclusion ability based on a radially functionalized hexagonal structure of 1, (ii) the correlation between the hydrogen bond donor ability of the syn and anti protons of the primary amide group in host 1 and the hydrogen bond acceptor ability of the oxygen atoms of 1 and guest solvents, and (iii) the polarity of the bulk crystallization solvents.	Oxygen	358-364	synemin	Homo sapiens	254-257
12590568-0	2003	Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.	Oxygen	0-6	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	90-139
12590568-1	2003	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DbetaM) are homologous copper-containing enzymes that catalyze an oxygen-dependent hydroxylation of peptide-extended glycine residues and phenethylamines, respectively.	Oxygen	40-46	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
11734856-8	2001	Application of an IPAS antisense oligonucleotide to the mouse cornea induced angiogenesis under normal oxygen conditions, and demonstrated hypoxia-dependent induction of VEGF gene expression in hypoxic corneal cells.	Oxygen	103-109	hypoxia inducible factor 3, alpha subunit	Mus musculus	18-22
11688972-0	2001	Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors.	Oxygen	69-75	PAS domain containing serine/threonine kinase	Homo sapiens	10-16
35050069-10	2022	Interestingly, the induction of AtDIC1 and AtDIC2 is abrogated in the erfVII mutant that is devoid of plant oxygen sensing, suggesting that these genes are part of a conserved hypoxia response in Arabidopsis.	Oxygen	108-114	uncoupling protein 5	Arabidopsis thaliana	32-38
11592937-1	2001	Nitric oxide (NO) production by endothelial nitric oxide synthase (eNOS) regulates renal O(2) consumption.	Oxygen	89-93	nitric oxide synthase 3	Canis lupus familiaris	32-65
11592937-1	2001	Nitric oxide (NO) production by endothelial nitric oxide synthase (eNOS) regulates renal O(2) consumption.	Oxygen	89-93	nitric oxide synthase 3	Canis lupus familiaris	67-71
12406846-7	2003	After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups.	Oxygen	17-19	myeloperoxidase	Mus musculus	68-83
12406846-7	2003	After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups.	Oxygen	34-36	myeloperoxidase	Mus musculus	68-83
34908040-2	2022	Herein, Cu2O particles self-supported on Cu foam with enriched oxygen vacancies are developed to enable selective NO2- reduction to NH3, exhibiting a maximum NH3 yield rate of 7510.73 mug h-1 cm-2 and high faradaic efficiency of 94.21% at -0.6 V in 0.1 M PBS containing 0.1 M NaNO2.	Oxygen	63-69	H1.5 linker histone, cluster member	Homo sapiens	188-196
12513985-8	2003	However, only the ole1 mutant strain responded to the oxygen pulse during the stationary phase, suggesting that de novo sterol synthesis is required for the oxygen-induced increase of the specific fermentation rate.	Oxygen	54-60	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	18-22
12513985-8	2003	However, only the ole1 mutant strain responded to the oxygen pulse during the stationary phase, suggesting that de novo sterol synthesis is required for the oxygen-induced increase of the specific fermentation rate.	Oxygen	157-163	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	18-22
11722568-5	2001	rNOX1 catalyzes the oxidation of NADH, producing both H(2)O(2) and H(2)O as reduction products of O(2) (O(2) + 1-2NADH + 1-2H(+) --&gt; 1-2NAD(+) + H(2)O(2) or 2H(2)O).	Oxygen	58-62	NADPH oxidase 1	Rattus norvegicus	0-5
11722568-5	2001	rNOX1 catalyzes the oxidation of NADH, producing both H(2)O(2) and H(2)O as reduction products of O(2) (O(2) + 1-2NADH + 1-2H(+) --&gt; 1-2NAD(+) + H(2)O(2) or 2H(2)O).	Oxygen	98-102	NADPH oxidase 1	Rattus norvegicus	0-5
34911050-2	2022	The zone centered vibrational phonon frequencies shows, there is a blue shift in the mid and high frequency range from Cl   Br due to change in mass and force constant with respect to oxygen atom.	Oxygen	184-190	chromosome 12 open reading frame 73	Homo sapiens	124-126
11765971-4	2001	The effects of endothelin-1 on arterial blood partial pressure of CO2 were not synchronised with the changes in O2 partial pressure and the responses were markedly different in trout and dogfish.	Oxygen	67-69	endothelin 1	Bos taurus	15-27
12804388-10	2003	MAIN RESULTS: Nasal CPAP, when applied to preterm infants being extubated following IPPV, reduces the incidence of adverse clinical events (apnea, respiratory acidosis and increased oxygen requirements) indicating the need for additional ventilatory support [RR 0.62 (0.49, 0.77), RD -0.17 (-0.24,-0.10), NNT 6 (4,10)].	Oxygen	182-188	centromere protein J	Homo sapiens	20-24
34983560-6	2022	Furthermore, the GOx/CAT cascade reaction producing consecutive fluxes of oxygen spatially targets the neutral wound tissue, and accelerates the proliferation and remodeling phases of wound healing by addressing the issues of hyperglycemia, hypoxia, and excessive oxidative stress.	Oxygen	74-80	hydroxyacid oxidase 1, liver	Mus musculus	17-20
12570801-5	2003	Finally, we will present recent advances into oxygen-sensing, in particular the HIF-hydroxylases that govern HIF-1alpha instability (PHD2) or inactivation (FIH-1).	Oxygen	46-52	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	156-161
11576932-3	2001	In mesangial and endothelial cells, the AGE-RAGE interaction caused enhanced formation of oxygen radicals with subsequent activation of nuclear factor-kappaB and release of pro-inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha), growth factors (transforming growth factor-beta1 [TGF-beta1], insulin-like growth factor-1), and adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1).	Oxygen	90-96	long intergenic non-protein coding RNA 914	Homo sapiens	44-48
35463920-4	2022	We had previously introduced a Forster resonance energy transfer (FRET) method to read out the deoxygenation/oxygenation states of myoglobin, by creating the targetable oxygen (O2) sensor Myoglobin-mCherry.	Oxygen	169-175	myoglobin	Homo sapiens	131-140
11595753-4	2001	A 4-h incubation of astrocytes in the absence of glucose, or under an oxygen-poor (3%) atmosphere also resulted in GLUT3 mRNA overexpression.	Oxygen	70-76	solute carrier family 2 member 3	Rattus norvegicus	115-120
12552146-6	2003	The maximal photosynthetic capacity and the quantum efficiency of oxygen evolution were diminished by 8-14% in the PSI-H-less plants.	Oxygen	66-72	photosystem I subunit H-1	Arabidopsis thaliana	115-120
35463920-4	2022	We had previously introduced a Forster resonance energy transfer (FRET) method to read out the deoxygenation/oxygenation states of myoglobin, by creating the targetable oxygen (O2) sensor Myoglobin-mCherry.	Oxygen	169-175	myoglobin	Homo sapiens	188-197
11526541-0	2001	Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes.	Oxygen	54-60	caspase 8	Rattus norvegicus	14-22
35463920-4	2022	We had previously introduced a Forster resonance energy transfer (FRET) method to read out the deoxygenation/oxygenation states of myoglobin, by creating the targetable oxygen (O2) sensor Myoglobin-mCherry.	Oxygen	177-179	myoglobin	Homo sapiens	131-140
12477933-5	2002	In particular the intermediate spin states of NO (S = 32) and O2 (S = 1) are shown to be bound states.	Oxygen	62-64	spindlin 1	Homo sapiens	31-35
12477933-7	2002	The slower phases of O2 recombination can be explained by the presence of two higher spin states, S = 2 and S = 3, which have a small and relatively large barrier to ligand recombination, respectively.	Oxygen	21-23	spindlin 1	Homo sapiens	85-89
12427234-12	2002	CONCLUSIONS: Retinal NPY and NPY Y2 receptor expression are altered in the development of oxygen-induced retinopathy of the mouse, during both the hyperoxic vasoconstrictive phase and the period of retinal neovascularization.	Oxygen	90-96	neuropeptide Y receptor Y2	Mus musculus	29-44
11533337-7	2001	TIMP-2 levels were lower in infants with initial arterial to alveolar oxygen tension ratios &lt;0.22 (2.7 +/- 1.1 vs 16.8 +/- 7.4 AU/SC) and in infants needing mechanical ventilation for &gt;1 week (5.2 +/- 2.1 vs 22.8 +/- 11.7 AU/SC).	Oxygen	70-76	TIMP metallopeptidase inhibitor 2	Homo sapiens	0-6
11429401-0	2001	Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen.	Oxygen	69-75	neuroglobin	Homo sapiens	6-17
35463920-4	2022	We had previously introduced a Forster resonance energy transfer (FRET) method to read out the deoxygenation/oxygenation states of myoglobin, by creating the targetable oxygen (O2) sensor Myoglobin-mCherry.	Oxygen	177-179	myoglobin	Homo sapiens	188-197
12430012-3	2002	In enteric bacteria, inhibition of acetolactate synthase (ALS), or the production of peracetic acid by this enzyme, may be a contributing factor in the inactivation of dihydroxyacid dehydratase and loss of the ability to synthesize branched-chain amino acids under conditions of hyperbaric oxygen.	Oxygen	290-296	olfactory receptor family 10 subfamily B member 1 pseudogene	Homo sapiens	35-56
35463920-5	2022	In this sensor, changes in myoglobin absorbance features that occur with lost O2 occupancy -or upon metMb production- control the FRET rate from the fluorescent protein to myoglobin.	Oxygen	78-80	myoglobin	Homo sapiens	27-36
35463920-5	2022	In this sensor, changes in myoglobin absorbance features that occur with lost O2 occupancy -or upon metMb production- control the FRET rate from the fluorescent protein to myoglobin.	Oxygen	78-80	myoglobin	Homo sapiens	172-181
12234194-4	2002	Lipoxygenase catalyzes an oxygenation reaction on each of the aforementioned thiols, as judged by the consumption of O(2).	Oxygen	117-121	linoleate 9S-lipoxygenase-4	Glycine max	0-12
11710806-2	2001	It was confirmed by monitoring oxygen consumption by isolated rat liver mitochondria that, beginning from 5 microM, Cd2+ decreased both ADP and uncoupler-stimulated respiration and increased their basal respiration when succinate was used as respiratory substrate.	Oxygen	31-37	Cd2 molecule	Rattus norvegicus	116-119
35463920-10	2022	More discriminatory power is then achieved when the fluorescent protein EYFP is added to Myoglobin-mCherry, creating a sandwich probe whose lifetime can selectively respond to metMb while being indifferent to O2 occupancy.	Oxygen	209-211	myoglobin	Homo sapiens	89-98
2556968-14	1989	Since the cytosol normally maintains a highly oxidized NAD+/NADH redox ratio, it is interesting to speculate that increased availability of NADH from the oxidation of ethanol may support microsomal reduction of iron complexes, with the subsequent generation of reactive oxygen intermediates.	Oxygen	270-276	2,4-dienoyl-CoA reductase 1	Homo sapiens	140-144
11463854-0	2001	A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.	Oxygen	19-25	thyroid stimulating hormone receptor	Homo sapiens	103-115
11463854-10	2001	Moreover, the mutagenesis results, together with a three-dimensional structure model, indicate that for TSH receptor activation and G protein-coupled signaling, at least one free available carboxylate oxygen is required as a hydrogen acceptor atom at position 674 in transmembrane domain 7.	Oxygen	201-207	thyroid stimulating hormone receptor	Homo sapiens	104-116
11476318-2	2001	Both ORP150 and HO1 have been reported to have important roles in the successful adaptation to oxygen deprivation.	Oxygen	95-101	hypoxia up-regulated 1	Rattus norvegicus	5-11
11341407-8	2001	In both breed-types, hemoglobin oxygen affinity was increased in calves with diarrhea, compared with healthy calves, as indicated by a decrease in standard partial oxygen pressure (P50).	Oxygen	32-38	secernin 1	Bos taurus	181-184
11372865-0	2001	Effects of oxygen on formation of PCB and PCDD/F on extracted fly ash in the presence of carbon and cupric salt.	Oxygen	11-17	Pyruvate carboxylase	Drosophila melanogaster	34-37
11372865-1	2001	The effect of oxygen-nitrogen atmosphere (N2 + 10%O2, N2 + 1%O2 and 99.999% N2) on the formation of PCB, PCDD and PCDF by the de novo synthetic reactions in the system consisting of extracted fly ash (from municipal waste incinerators--MWI), activated carbon, CuCl2 x 2H2O and NaCl at 340 degrees C was studied.	Oxygen	14-20	Pyruvate carboxylase	Drosophila melanogaster	100-103
11372865-1	2001	The effect of oxygen-nitrogen atmosphere (N2 + 10%O2, N2 + 1%O2 and 99.999% N2) on the formation of PCB, PCDD and PCDF by the de novo synthetic reactions in the system consisting of extracted fly ash (from municipal waste incinerators--MWI), activated carbon, CuCl2 x 2H2O and NaCl at 340 degrees C was studied.	Oxygen	50-52	Pyruvate carboxylase	Drosophila melanogaster	100-103
11372865-1	2001	The effect of oxygen-nitrogen atmosphere (N2 + 10%O2, N2 + 1%O2 and 99.999% N2) on the formation of PCB, PCDD and PCDF by the de novo synthetic reactions in the system consisting of extracted fly ash (from municipal waste incinerators--MWI), activated carbon, CuCl2 x 2H2O and NaCl at 340 degrees C was studied.	Oxygen	61-63	Pyruvate carboxylase	Drosophila melanogaster	100-103
11297741-2	2001	Both predicted proteins consist of 258 amino acid residues (77% identity) which show sequence similarity to di-iron-binding enzymes, such as Sur2p and Erg3p from yeast, involved in oxygen-dependent lipid modifications.	Oxygen	181-187	sphingosine hydroxylase	Saccharomyces cerevisiae S288C	141-146
11297741-2	2001	Both predicted proteins consist of 258 amino acid residues (77% identity) which show sequence similarity to di-iron-binding enzymes, such as Sur2p and Erg3p from yeast, involved in oxygen-dependent lipid modifications.	Oxygen	181-187	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	151-156
11273911-0	2001	The relationship between plasma concentration of mature adrenomedullin and jugular venous oxygen saturation during and after cardiopulmonary bypass.	Oxygen	90-96	adrenomedullin	Homo sapiens	56-70
11273911-9	2001	IMPLICATIONS: Plasma concentrations of mature-form adrenomedullin, a vasodilatory peptide, was correlated with jugular venous oxygen saturation during cardiac surgery.	Oxygen	126-132	adrenomedullin	Homo sapiens	51-65
11273911-10	2001	This suggests a relationship between adrenomedullin and cerebral oxygen balance during cardiac surgery.	Oxygen	65-71	adrenomedullin	Homo sapiens	37-51
11355387-10	2001	Recent in vitro results on fibroblasts transfected with HO-1 cDNA showed that, despite cytoprotection with low (less than fivefold compared with untransfected cells) HO-1 activity, high levels of HO-1 expression (more than 15-fold) were associated with significant oxygen toxicity.	Oxygen	265-271	heme oxygenase 1	Rattus norvegicus	56-60
11260386-9	2001	During tempol, SHR given vehicle or HHR had a much increased response to blockade of nNOS with 7-NI (DeltaTGF in SHR with 7-NI during tempol: Veh 6.3 +/- 1.0 and HHR 4.5 +/- 0.8 mm Hg, P &lt; 0.01 vs. no tempol for both), implying that the effects of NO had been prevented because of excessive O2-.	Oxygen	294-296	nitric oxide synthase 1	Rattus norvegicus	85-89
11237772-2	2001	HIF plays key roles in oxygen homeostasis and embryonic cardiovascular development.	Oxygen	23-29	aryl hydrocarbon receptor nuclear translocator	Gallus gallus	0-3
11241092-8	2001	All 3 groups exhibited significant increases in alveolar-arterial oxygen gradient (P &lt;.0001), significant decreases in dynamic lung compliance (P &lt;.0001), and significant decreases in static lung compliance (P &lt;.0001) during the immediate postoperative period, with no differences between groups.	Oxygen	66-72	paired box 5	Homo sapiens	0-5
11224519-3	2001	Electrons are initially transferred from NADPH to cytochrome b-associated FAD, then to cytochrome b heme and finally to molecular oxygen.	Oxygen	130-136	mitochondrially encoded cytochrome b	Homo sapiens	50-62
11341971-9	2001	However, such marked changes in the transcript levels of HKII and GLUT1 were not observed when AH130 cells were cultured in dishes under a hypoxic condition, indicating that the observed changes were not solely attributable to the difference in oxygen concentration between the ascites and cell culture conditions.	Oxygen	245-251	hexokinase 2	Rattus norvegicus	57-61
11022032-2	2001	It is also shown that molecular oxygen competes considerably with the prenylquinones in cytochrome b(559) oxidation under aerobic conditions, indicating that both molecular oxygen and plastoquinones could be electron acceptors from cytochrome b(559) in PSII preparations.	Oxygen	32-38	mitochondrially encoded cytochrome b	Homo sapiens	88-100
11022032-2	2001	It is also shown that molecular oxygen competes considerably with the prenylquinones in cytochrome b(559) oxidation under aerobic conditions, indicating that both molecular oxygen and plastoquinones could be electron acceptors from cytochrome b(559) in PSII preparations.	Oxygen	32-38	mitochondrially encoded cytochrome b	Homo sapiens	232-244
11022032-2	2001	It is also shown that molecular oxygen competes considerably with the prenylquinones in cytochrome b(559) oxidation under aerobic conditions, indicating that both molecular oxygen and plastoquinones could be electron acceptors from cytochrome b(559) in PSII preparations.	Oxygen	173-179	mitochondrially encoded cytochrome b	Homo sapiens	88-100
11022032-2	2001	It is also shown that molecular oxygen competes considerably with the prenylquinones in cytochrome b(559) oxidation under aerobic conditions, indicating that both molecular oxygen and plastoquinones could be electron acceptors from cytochrome b(559) in PSII preparations.	Oxygen	173-179	mitochondrially encoded cytochrome b	Homo sapiens	232-244
11139052-0	2001	Regional myocardial metabolic rate of oxygen measured by O2-15 inhalation and positron emission tomography in patients with cardiomyopathy.	Oxygen	38-44	immunoglobulin kappa variable 1D-39	Homo sapiens	57-62
11139052-2	2001	Recently, quantitative measurements of the metabolic rate of oxygen (MMRO2) and oxygen extraction fraction (OEF) using O2-15-labeled oxygen gas have been validated in animals and healthy volunteers.	Oxygen	61-67	immunoglobulin kappa variable 1D-39	Homo sapiens	119-124
11139052-2	2001	Recently, quantitative measurements of the metabolic rate of oxygen (MMRO2) and oxygen extraction fraction (OEF) using O2-15-labeled oxygen gas have been validated in animals and healthy volunteers.	Oxygen	80-86	immunoglobulin kappa variable 1D-39	Homo sapiens	119-124
11139052-2	2001	Recently, quantitative measurements of the metabolic rate of oxygen (MMRO2) and oxygen extraction fraction (OEF) using O2-15-labeled oxygen gas have been validated in animals and healthy volunteers.	Oxygen	80-86	immunoglobulin kappa variable 1D-39	Homo sapiens	119-124
11544833-5	2001	Indirect evidence on PCNA immunostaining suggested that synthesis of this cyclin is sensitive to the level of oxygen input in the cell, yet it offers sufficient resistance to gamma-radiation.	Oxygen	110-116	proliferating cell nuclear antigen	Rattus norvegicus	21-25
11104700-2	2000	We investigated the transcriptional control of AAC3, an oxygen-repressed isoform.	Oxygen	56-62	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	47-51
11104700-6	2000	These findings demonstrate that the hypoxic AAC3 gene is regulated by two upstream repressor sites; one controlled by oxygen and haem, the other by the carbon source.	Oxygen	118-124	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	44-48
10969075-9	2000	These results indicate that SP-A and SP-D, which are ubiquitous among air breathing organisms, could contribute to the protection of the lung from oxidative stresses due to atmospheric or supplemental oxygen, air pollutants, and lung inflammation.	Oxygen	201-207	surfactant protein D	Homo sapiens	37-41
11153394-0	2000	[Early application of CPAP in newborns with gestational age below 34 weeks lowers intubation rate and shortens oxygen therapy without altering mortality and morbidity].	Oxygen	111-117	centromere protein J	Homo sapiens	22-26
11168498-1	2000	Flavocytochrome b558 (Cyt b) is important in generating superoxide and other toxic oxygen species involved in inflammation and host defense.	Oxygen	83-89	mitochondrially encoded cytochrome b	Homo sapiens	22-27
11134568-9	2000	CONCLUSION: When cultured at 1-percent O(2) for 7 days in presence of IL-3 and SCF, the CD34+ cells present in apheresis components underwent more cell divisions and better maintained their primitive progenitor cell potential.	Oxygen	39-43	KIT ligand	Homo sapiens	79-82
11084289-10	2000	In the presence of oxygen a different species was observed with DEPMPO, DPPMPO, and DBPMPO, which was only slightly suppressed upon the addition of SOD, possibly the respective spin adduct of either the alkylperoxyl radical or, in analogy to DMPO, a secondary alkoxyl radical.	Oxygen	19-25	spindlin 1	Homo sapiens	177-181
11053346-5	2000	Western blot analyses indicated that HIF-1alpha rapidly accumulated during the onset of hypoxia and did not fall for 14 days but fell to normal by 21 days despite the continuous low arterial oxygen tension.	Oxygen	191-197	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	37-47
11053346-8	2000	When 21-day-adapted rats were exposed to a more severe hypoxic challenge (8% oxygen), HIF-1alpha accumulated again.	Oxygen	77-83	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	86-96
11101212-3	2000	A dialysis electrode continuously perfused with glutamate oxidase and ferrocene-conjugated bovine serum albumin (BSA) optimized the time resolution of monitoring, allowing quantitative oxygen-independent, real-time measurement of the extracellular glutamate concentration ([Glu]e) during anoxia.	Oxygen	185-191	albumin	Rattus norvegicus	98-111
11032742-8	2000	Using a human thioredoxin in which the structural cysteines were mutated to alanine, Trx-C3A, we show that structural cysteines that do not take part in the catalytic functions of the protein are also important for its reactive oxygen scavenging properties.	Oxygen	228-234	complement C3	Homo sapiens	89-92
11024540-2	2000	The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates.	Oxygen	96-102	heme oxygenase 1	Rattus norvegicus	28-32
11001904-6	2000	In contrast, eosinophils derived from Syk-deficient but not wild-type mice were incapable of generating reactive oxygen intermediates in response to Fcgamma receptor (FcgammaR) engagement.	Oxygen	113-119	spleen tyrosine kinase	Mus musculus	38-41
10973828-2	2000	However, we had found that the NO donor compounds 2-(N, N-diethylamino)-diazenolate-2-oxide (DEANO) and S-nitrosocysteine (CysNO) caused increased oxygen affinity of red cells from both AA and SS individuals and also caused significant methemoglobin (metHb) formation.	Oxygen	147-153	hemoglobin subunit gamma 2	Homo sapiens	236-249
10973828-2	2000	However, we had found that the NO donor compounds 2-(N, N-diethylamino)-diazenolate-2-oxide (DEANO) and S-nitrosocysteine (CysNO) caused increased oxygen affinity of red cells from both AA and SS individuals and also caused significant methemoglobin (metHb) formation.	Oxygen	147-153	hemoglobin subunit gamma 2	Homo sapiens	251-256
10969977-1	2000	The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized.	Oxygen	70-76	placenta associated 8	Homo sapiens	92-96
10924123-2	2000	The transition from an inactive to an active oxidase complex induces the transfer of electrons from NADPH to oxygen through cytochrome b(558).	Oxygen	109-115	mitochondrially encoded cytochrome b	Homo sapiens	124-136
11035251-0	2000	Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.	Oxygen	141-147	NAD(P)H dehydrogenase, quinone 1	Mus musculus	25-64
10929046-6	2000	We showed that the exchange of human zeta-globin for human alpha-globin chains increased haemoglobin O2 affinity, both in the presence and in the absence of 2, 3-bisphosphoglycerate (2,3-BPG), and reduced the pH-dependent shift in its oxygen equilibrium curve (Bohr effect).	Oxygen	235-241	hemoglobin subunit zeta	Homo sapiens	37-48
10747889-5	2000	If a comparable interaction occurs in catalysis, then Gln(382) may provide electrostatic stabilization of partial negative charge on the epoxide oxygen.	Oxygen	145-151	interferon alpha	Mus musculus	0-4
10781441-0	2000	Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury.	Oxygen	63-69	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	12-49
10781441-0	2000	Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury.	Oxygen	63-69	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	51-54
10781441-7	2000	By 84 h of oxygen exposure, TNFR-I(-/-) mice demonstrated greater alveolar debris, inflammation, and edema than WT mice.	Oxygen	11-17	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	28-34
10781441-11	2000	Differences in early survival and toxicity suggest that pulmonary oxygen toxicity is in part mediated by TNFR-I.	Oxygen	66-72	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	105-111
10865838-7	2000	At low O2 tension, hypoxia inducible factor-1 alpha (HIF-1 alpha), a limiting factor rapidly stabilized and phosphorylated, plays a key role in the expression of several genes including VEGF.	Oxygen	7-9	vascular endothelial growth factor A	Mus musculus	186-190
10879688-0	2000	Human MO subsets as defined by expression of CD64 and CD16 differ in phagocytic activity and generation of oxygen intermediates.	Oxygen	107-113	Fc gamma receptor IIIa	Homo sapiens	54-58
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Oxygen	28-34	synemin	Homo sapiens	170-173
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Oxygen	28-34	synemin	Homo sapiens	174-177
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Oxygen	28-34	synemin	Homo sapiens	174-177
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Oxygen	28-34	synemin	Homo sapiens	174-177
10839460-11	2000	Since this is a weaker nucleophil than the para-hydroxylated substrates, the binding constant decreases, leading to an increase in K(M)m. The catalytic efficiency of tyrosinase on a monophenol (para or meta) is directly related to the nucleophilic power of the oxygen of the phenolic OH.	Oxygen	261-267	tyrosinase	Homo sapiens	166-176
10733977-5	2000	The Asn, Thr, and Gly residues involved in hydrogen bonding to the DNA bases and sugar oxygens form a relatively rigid motif in TBP.	Oxygen	87-94	TATA-box binding protein	Homo sapiens	128-131
10776552-1	2000	It was shown that raising pod seedlings by the hydroponics method on KH2PO4 solutions at concentrations between 10(-7) and 10(-5) M leads to an increase in the rate of oxygen release (delta O2/delta t), with the chlorophyll content in leaves being unchanged.	Oxygen	168-174	immunoglobulin kappa variable 1D-39	Homo sapiens	190-198
10720691-6	2000	Also, total, CD15(bright)/CD11b(-) (promyelocytes, early myelocytes), and CD15(bright)/CD11b(+) cell expansion was enhanced at lower pO(2), with twice as many of each cell type produced at 5% O(2) as at 20% O(2).	Oxygen	134-138	integrin subunit alpha M	Homo sapiens	87-92
10666024-0	2000	Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS.	Oxygen	11-17	intercellular adhesion molecule 1	Homo sapiens	32-38
10666107-1	2000	Intercellular adhesion molecule-1 (ICAM-1) of the vascular endothelium plays a key role in the development of pulmonary oxygen toxicity.	Oxygen	120-126	intercellular adhesion molecule 1	Homo sapiens	0-33
10666107-1	2000	Intercellular adhesion molecule-1 (ICAM-1) of the vascular endothelium plays a key role in the development of pulmonary oxygen toxicity.	Oxygen	120-126	intercellular adhesion molecule 1	Homo sapiens	35-41
10702765-9	2000	A negative correlation between WAT O2 consumption and UCP2 expression was found in control animals, but not in the cafeteria-fed groups, suggesting a differential response to the beta3-adrenergic compound in lean and obese animals, which is in agreement with the reported statistical interactions between obesity and Trecadrine administration found for WAT O2 consumption and muscle UCP2 expression, as well as for plasma leptin and WAT leptin expression.	Oxygen	35-37	uncoupling protein 2	Rattus norvegicus	54-58
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	67-73	uncharacterized protein LOC100285036	Zea mays	99-120
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	205-211	uncharacterized protein LOC100285036	Zea mays	99-120
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	252-254	uncharacterized protein LOC100285036	Zea mays	99-120
10938850-9	2000	A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)].	Oxygen	266-268	uncharacterized protein LOC100285036	Zea mays	99-120
10897413-2	2000	This transport chain is contained mainly in the large membrane subunit of the oxidase (gp91phox), and transfers electrons from cytosolic NADPH, through FAD binding and heme centers, to molecular oxygen (Babior, 1999; Fujii and Kakinuma, 1991; Rotrosen et al., 1992; Segal and Abo, 1993).	Oxygen	195-201	cytochrome b-245 beta chain	Homo sapiens	87-95
10897413-2	2000	This transport chain is contained mainly in the large membrane subunit of the oxidase (gp91phox), and transfers electrons from cytosolic NADPH, through FAD binding and heme centers, to molecular oxygen (Babior, 1999; Fujii and Kakinuma, 1991; Rotrosen et al., 1992; Segal and Abo, 1993).	Oxygen	195-201	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	276-279
10849669-4	2000	Given the similarities between NO and O2, we hypothesized that NO inhibits hypoxia-induced up-regulation of c-fos and TH.	Oxygen	38-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	108-113
10849669-7	2000	Hypoxia (1% O2 for 6 h) up-regulated c-fos and TH mRNA and increased c-fos promoter activity.	Oxygen	12-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
10849669-7	2000	Hypoxia (1% O2 for 6 h) up-regulated c-fos and TH mRNA and increased c-fos promoter activity.	Oxygen	12-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
10640274-3	2000	We find that p53 promotes Mdm2-mediated ubiquitination and proteasomal degradation of the HIF-1alpha subunit of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that regulates cellular energy metabolism and angiogenesis in response to oxygen deprivation.	Oxygen	259-265	MDM2 proto-oncogene	Homo sapiens	26-30
10640413-1	2000	In human medicine, pulse oximetry is widely used to measure non-invasively and accurately the percentage of oxygen saturation of arterial haemoglobin (SpO(2)).	Oxygen	108-114	synaptoporin	Mus musculus	151-154
10585212-4	1999	The introduction of an oxygen-containing functionality to the propyl side chain provided ketones 29 and 30, which demonstrated greatly reduced affinity for the DAT and decreased potency in inhibiting the uptake of [(3)H]DA, and benzylic alcohols 31-36, which were highly potent and selective at binding to the DAT and inhibiting [(3)H]DA uptake.	Oxygen	23-29	solute carrier family 6 member 3	Homo sapiens	160-163
10585212-4	1999	The introduction of an oxygen-containing functionality to the propyl side chain provided ketones 29 and 30, which demonstrated greatly reduced affinity for the DAT and decreased potency in inhibiting the uptake of [(3)H]DA, and benzylic alcohols 31-36, which were highly potent and selective at binding to the DAT and inhibiting [(3)H]DA uptake.	Oxygen	23-29	solute carrier family 6 member 3	Homo sapiens	310-313
10883296-10	1999	The multivariate analysis showed an association of Tal score and NS on admission, with days receiving oxygen therapy.	Oxygen	102-108	transaldolase 1	Homo sapiens	51-54
10673153-10	1999	Thus, Mpv17-/- mice unravel an intriguing new association between a defect in reactive oxygen metabolism and the age-dependent development of hypertension.	Oxygen	87-93	MpV17 mitochondrial inner membrane protein	Mus musculus	6-11
10556660-6	1999	These results show that active oxygens introduced by passive smoking may contribute to K-ras activation as an initiator of a tumor model, possibly through the oxygen-induced DNA damage, and may also contribute to an initial activation and the subsequent down-regulation of PKC as a promoter.	Oxygen	31-38	KRAS proto-oncogene, GTPase	Rattus norvegicus	87-92
10556660-6	1999	These results show that active oxygens introduced by passive smoking may contribute to K-ras activation as an initiator of a tumor model, possibly through the oxygen-induced DNA damage, and may also contribute to an initial activation and the subsequent down-regulation of PKC as a promoter.	Oxygen	31-37	KRAS proto-oncogene, GTPase	Rattus norvegicus	87-92
10582858-10	1999	Partial pressures of oxygen required for various degrees of hemoglobin saturation were higher in meconium-exposed samples; P50 (30.1+/-0.6 vs. 27.8+/-0.4 mmHg, P &lt; 0.01); P75 (46.9+/-0.6 vs. 43.1+/-0.5 mmHg, P &lt; .001); P90 (69.2+/-1 vs. 63.3+/-1 mmHg, P &lt; 0.01).	Oxygen	21-27	cellular inhibitor of PP2A	Homo sapiens	225-228
10512752-3	1999	The two phosphonate groups of the 1,1-bisphosphonates readily dock into the diphosphate-Mg(2+) binding site in farnesyl diphosphate synthase, while the charged ammonium (or pyridinium or imidazolium) groups act as carbocation transition state analogs, whose binding is stabilized by a cluster of oxygen atoms in the active site cleft, and an overall negative electrostatic potential in this region.	Oxygen	296-302	farnesyl diphosphate synthase	Homo sapiens	111-140
10517852-2	1999	We show here that invertase gene expression and the invertase-sucrose (Suc) synthase ratio decrease abruptly in response to low oxygen in maize root tips.	Oxygen	128-134	invertase 2	Zea mays	18-27
10517852-2	1999	We show here that invertase gene expression and the invertase-sucrose (Suc) synthase ratio decrease abruptly in response to low oxygen in maize root tips.	Oxygen	128-134	invertase 2	Zea mays	52-61
10517852-6	1999	Rapid repression of the Ivr1 and Ivr2 maize invertases by low oxygen was evident in root tips within 3 h at both the transcript and activity levels.	Oxygen	62-68	invertase 2	Zea mays	33-37
10487921-7	1999	The results of internal deletion studies of the promoter region suggested that there was also a region responsible for ATF1 oxygen regulation.	Oxygen	124-130	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	119-123
10487921-12	1999	Thus, the activation of ATF1 transcription is dependent on Rap1p, and the Rox1p-Tup1p-Ssn6p hypoxic repressor complex is responsible for repression by oxygen.	Oxygen	151-157	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	24-28
10457294-9	1999	RESULTS: Nasal CPAP, when applied to preterm infants being extubated following IPPV, reduces the incidence of adverse clinical events (apnoea, respiratory acidosis and increased oxygen requirements) indicating the need for additional ventilatory support.	Oxygen	178-184	centromere protein J	Homo sapiens	15-19
10409680-5	1999	It is proposed that TspO, by regulating the exit of certain tetrapyrrole intermediates of the heme/bacteriochlorophyll biosynthetic pathways in R. sphaeroides in response to the availability of molecular oxygen, causes the accumulation of a biosynthetic intermediate that serves as a corepressor for both specific pigment gene transcription and the puc operon.	Oxygen	204-210	translocator protein	Homo sapiens	20-24
10407142-1	1999	Heme oxygenase catalyzes the regiospecific oxidative degradation of iron protoporphyrin IX (heme) to biliverdin, CO and Fe, utilizing molecular oxygen and electrons donated from the NADPH-cytochrome P-450 reductase.	Oxygen	5-11	cytochrome p450 oxidoreductase	Rattus norvegicus	182-214
10431807-9	1999	The two naturally occurring uncoupling protein 3 mutants, V9M and V102I, were similar to uncoupling protein 3L with respect to effects on the yeast growth and whole yeast O2 consumption.	Oxygen	171-173	uncoupling protein 3	Homo sapiens	28-48
10401038-7	1999	The transcriptional effect of hypoxia is mediated by dual mechanisms operating in parallel, namely, (1) enhancement of Glut1 gene transcription in response to a reduction in oxygen concentration per se, acting through the hypoxia-signaling pathway, and (2) stimulation of Glut1 transcription secondary to the associated inhibition of oxidative phosphorylation during hypoxia.	Oxygen	174-180	solute carrier family 2 member 1	Homo sapiens	119-124
10442959-5	1999	Anesthesia was maintained with N2O 50-66% (2-3 L x min(-1)) and isoflurane (&lt;IMAC) in oxygen combined with thoracic epidural anesthesia.	Oxygen	89-95	C-C motif chemokine ligand 26	Homo sapiens	80-84
10452227-3	1999	These findings show that the Aerosport KB1-C portable metabolic system is acceptable for measuring oxygen uptake in the range of 1.5 and 3.5 L x min(-1), using the medium flow pneumotach setting.	Oxygen	99-105	folate receptor 1 pseudogene 1	Homo sapiens	39-42
10387045-3	1999	In this study, we have generated a stable ferrous-O2 complex of the oxygenase domain of rat neuronal NOS (nNOS) by bubbling O2 through a solution of the dithionite-reduced enzyme at -30 degrees C in a cryogenic solvent containing 50% ethylene glycol.	Oxygen	50-52	nitric oxide synthase 1	Rattus norvegicus	92-104
10387045-3	1999	In this study, we have generated a stable ferrous-O2 complex of the oxygenase domain of rat neuronal NOS (nNOS) by bubbling O2 through a solution of the dithionite-reduced enzyme at -30 degrees C in a cryogenic solvent containing 50% ethylene glycol.	Oxygen	50-52	nitric oxide synthase 1	Rattus norvegicus	106-110
11674531-3	1999	The stereochemical outcome of the IMDAF cycloaddition has the sidearm of the tethered alkenyl group oriented syn with respect to the oxygen bridge.	Oxygen	133-139	synemin	Homo sapiens	109-112
10358107-3	1999	Cytosolic free calcium concentration ([Ca2+]i) has been implicated in cellular oxygen-sensing processes.	Oxygen	79-85	carbonic anhydrase 2	Homo sapiens	39-42
10362686-0	1999	Increases in oxygen tension stimulate expression of ICAM-1 and VCAM-1 on human endothelial cells.	Oxygen	13-19	intercellular adhesion molecule 1	Homo sapiens	52-58
10362686-5	1999	Subsequent rises in oxygen (21, 40, or 95% O2) led to marked increase of ICAM-1 and VCAM-1 cell surface and mRNA expression in both EC types, which after 16 h amounted to about one-third to one-half of maximal TNF-alpha-induced expression.	Oxygen	20-26	intercellular adhesion molecule 1	Homo sapiens	73-79
10362686-5	1999	Subsequent rises in oxygen (21, 40, or 95% O2) led to marked increase of ICAM-1 and VCAM-1 cell surface and mRNA expression in both EC types, which after 16 h amounted to about one-third to one-half of maximal TNF-alpha-induced expression.	Oxygen	43-45	intercellular adhesion molecule 1	Homo sapiens	73-79
10362686-9	1999	Moreover, the oxygen-induced rise could be mimicked by addition of H2O2 to normoxic cells, and the oxygen-induced expression of VCAM-1 but not of ICAM-1 was inhibited by addition of the free radical scavengers superoxide dismutase, N-acetyl-L-cysteine, and pyrrolidinedithiocarbamate.	Oxygen	99-105	intercellular adhesion molecule 1	Homo sapiens	146-152
10362686-10	1999	These data indicate that an increase in oxygen availability stimulates ICAM-1 and VCAM-1 expression on micro- and macrovascular EC, which may contribute to adhesion and transmigration of different leukocyte populations in ischemia-reperfusion injuries.	Oxygen	40-46	intercellular adhesion molecule 1	Homo sapiens	71-77
10354064-3	1999	PBR may function as an oxygen-dependent signal generator; recent data indicate that these receptors may preserve the mitochondria of haematopoietic cell lines from damage caused by oxygen radicals.	Oxygen	23-29	translocator protein	Homo sapiens	0-3
10403539-2	1999	AL-1 inhibited TPA-induced intracellular peroxide formation in differentiated HL-60 cells, suggesting that this suppression might be attributable to the inhibition of O2- generation.	Oxygen	167-169	ephrin A5	Homo sapiens	0-4
10336447-1	1999	The leukocyte NADPH oxidase is an enzyme present in phagocytes and B lymphocytes that when activated catalyzes the production of O-2 from oxygen at the expense of NADPH.	Oxygen	138-144	immunoglobulin kappa variable 1D-39	Homo sapiens	129-132
10329878-8	1999	RESULTS: Baseline PO2 before hypoxemia was significantly lower and oxygen content was significantly higher in fetuses in the long-term oxytocin group than in control fetuses.	Oxygen	67-73	oxytocin/neurophysin I prepropeptide	Homo sapiens	135-143
10329878-9	1999	At the end of hypoxemia the fetal pH, oxygen saturation, and oxygen content were significantly higher in the long-term oxytocin group than in the control group, although PO2 did not differ between groups.	Oxygen	61-67	oxytocin/neurophysin I prepropeptide	Homo sapiens	119-127
10329878-10	1999	The fetal blood oxygen dissociation curve was shifted to the left in the long-term oxytocin group.	Oxygen	16-22	oxytocin/neurophysin I prepropeptide	Homo sapiens	83-91
10330042-6	1999	During neonatal oxygen injury, its expression declined from 38 to 8% of VEGF message (P &lt; 0.002) and returned to the control value in recovery.	Oxygen	16-22	vascular endothelial growth factor A	Oryctolagus cuniculus	72-76
10194372-6	1999	This result contrasts with the reaction of Hred with dioxygen, in which the Hperoxo intermediate forms in measurable quantities only in the presence of protein B.	Oxygen	53-61	prolyl 3-hydroxylase 3	Homo sapiens	152-161
10037731-2	1999	In human embryonic kidney (HEK) cells stably overexpressing ORP150 antisense RNA, ORP150 antigen and transcripts were suppressed to low levels in normoxia and hypoxia, whereas wild-type cells showed induction of ORP150 with oxygen deprivation.	Oxygen	224-230	hypoxia up-regulated 1	Homo sapiens	60-66
10420575-2	1999	Infrared and solid state NMR 13C analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon.	Oxygen	135-141	complement C3	Homo sapiens	145-148
9988690-0	1999	Role of the flavin midpoint potential and NAD binding in determining NAD versus oxygen reactivity of xanthine oxidoreductase.	Oxygen	80-86	xanthine dehydrogenase	Bos taurus	101-124
9988690-2	1999	Enzyme forms differ in respect to their oxidizing substrates; XDH prefers NAD to molecular oxygen, whereas XO only reacts significantly with oxygen.	Oxygen	91-97	xanthine dehydrogenase	Bos taurus	62-65
9988690-2	1999	Enzyme forms differ in respect to their oxidizing substrates; XDH prefers NAD to molecular oxygen, whereas XO only reacts significantly with oxygen.	Oxygen	141-147	xanthine dehydrogenase	Bos taurus	62-65
9878449-11	1999	It is also predicted that the EF-3 site of TnC and the EF-1 site of CaM have their invariant Glu12 residues switching from the bidentate to the monodentate configuration when Ca2+ is substituted by Mg2+, with six oxygen atoms being observed in the co-ordination sphere of the alchemically generated Mg2+ cation.	Oxygen	213-219	tenascin C	Homo sapiens	43-46
9878744-8	1999	We conclude that (1) this study provided a framework on which the mechanisms underlying anoxia tolerance can be dissected in the fruit fly and (2) fau gene plays an important role in the regulation of tissue responsiveness to O2 deprivation.	Oxygen	226-228	fau	Drosophila melanogaster	147-150
10668426-3	1999	X-ray microanalysis was used to measure concentrations of Na, K, Ca and other elements in subcellular compartments (e.g., mitochondria) of CA1 neurons from oxygen/glucose-deprived (OGD) hippocampal slices.	Oxygen	156-162	carbonic anhydrase 1	Homo sapiens	139-142
10711761-1	1999	In order to evaluate the oxygen saturation of hemoglobin in living tissues we use a new experimental instrument: the optical oximeter (LOX).	Oxygen	25-31	lysyl oxidase	Homo sapiens	135-138
12181152-0	2002	Role of cardiac eNOS expression during pregnancy in the coupling of myocardial oxygen consumption to cardiac work.	Oxygen	79-85	nitric oxide synthase 3	Rattus norvegicus	16-20
12146979-1	2002	Stearoyl acyl carrier protein Delta(9) desaturase catalyzes the NADPH- and O(2)-dependent insertion of a cis double bond between the C-9 and C-10 positions of the acyl chain in the kinetically preferred natural substrate 18:0-ACP.	Oxygen	75-79	complement C9	Homo sapiens	133-136
21708785-5	2002	We show that oxygen consumption rate is correlated with the activity of key metabolic enzymes (e.g., citrate synthase and malate dehydrogenase) for some intertidal species, and concentrations of these enzymes in certain tissues are lower for starved individuals than for those that are well fed.	Oxygen	13-19	malic enzyme 1	Homo sapiens	122-142
12172383-1	2002	ORP150-150-kd oxygen-regulated protein-is a novel stress protein localized in the endoplasmic reticulum (ER).	Oxygen	14-20	hypoxia up-regulated 1	Homo sapiens	0-6
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	kinase insert domain receptor	Homo sapiens	110-125
12151519-8	2002	CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1).	Oxygen	20-22	kinase insert domain receptor	Homo sapiens	127-134
12089367-10	2002	The kidney demonstrates a marked potential for upregulation of HIF, but accumulation of HIF-1alpha and HIF-2alpha is selective with respect to cell type, kidney zone, and experimental conditions, with the expression patterns partly matching known oxygen profiles.	Oxygen	247-253	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98
12089367-10	2002	The kidney demonstrates a marked potential for upregulation of HIF, but accumulation of HIF-1alpha and HIF-2alpha is selective with respect to cell type, kidney zone, and experimental conditions, with the expression patterns partly matching known oxygen profiles.	Oxygen	247-253	endothelial PAS domain protein 1	Rattus norvegicus	103-113
12080085-4	2002	Like known hydroxylase enzymes, FIH-1 is an Fe(II)-dependent enzyme that uses molecular O(2) to modify its substrate.	Oxygen	88-92	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	32-37
12085336-1	2002	Oxygen metabolites generated by myeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase contribute to microbial killing by phagocytes.	Oxygen	0-6	myeloperoxidase	Mus musculus	32-47
12085336-1	2002	Oxygen metabolites generated by myeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase contribute to microbial killing by phagocytes.	Oxygen	0-6	myeloperoxidase	Mus musculus	49-52
12044899-2	2002	Genetic engineering of the active site of CcP, along with structural, spectroscopic, and kinetic characterization of the mutant proteins has provided considerable insight into the mechanism of hydrogen peroxide activation, oxygen-oxygen bond cleavage, and formation of the higher-oxidation state intermediates in heme enzymes.	Oxygen	230-236	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	42-45
12107766-1	2002	The manganese superoxide dismutase (Mn-SOD) converts superoxide anions to hydrogen peroxide plus oxygen, providing the first line of defense against oxidative stress in mitochondria.	Oxygen	97-103	superoxide dismutase 2	Rattus norvegicus	4-34
12107766-1	2002	The manganese superoxide dismutase (Mn-SOD) converts superoxide anions to hydrogen peroxide plus oxygen, providing the first line of defense against oxidative stress in mitochondria.	Oxygen	97-103	superoxide dismutase 2	Rattus norvegicus	36-42
12107766-3	2002	In mitochondria from both tissues Mn-SOD activity decreased after incubation at low oxygen concentration (hypoxic mitochondria).	Oxygen	84-90	superoxide dismutase 2	Rattus norvegicus	34-40
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Oxygen	126-132	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	44-48
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Oxygen	211-217	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	44-48
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Oxygen	211-217	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	249-253
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Oxygen	211-217	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	249-253
12072972-9	2002	In particular, the role of otherwise well-characterized proteins like rubrerythrin, NADH peroxidase, and rubredoxin:oxygen oxidoreductase in "anaerobic" oxygen metabolism has yet to be established.	Oxygen	116-122	thioredoxin reductase 1	Homo sapiens	123-137
12073205-16	2002	This deleterious effect of reoxygenation can be modified by initiating CPB at a lower level of oxygen concentration.	Oxygen	29-35	carboxypeptidase B1	Homo sapiens	71-74
12073205-17	2002	Subsequent long-term studies are needed to determine the best method of decreasing the oxygen concentration of the CPB circuit.	Oxygen	87-93	carboxypeptidase B1	Homo sapiens	115-118
12009413-0	2002	Mechanistic implications of variable stoichiometries of oxygen consumption during tyrosinase catalyzed oxidation of monophenols and o-diphenols.	Oxygen	56-62	tyrosinase	Homo sapiens	82-92
12009413-1	2002	The stoichiometry of oxygen consumption during tyrosinase-catalyzed oxidation of an o-diphenol (4-tert-butylcatechol, TBC) and a monophenol (4-tert-butylphenol, TBP) has been determined.	Oxygen	21-27	tyrosinase	Homo sapiens	47-57
12009413-1	2002	The stoichiometry of oxygen consumption during tyrosinase-catalyzed oxidation of an o-diphenol (4-tert-butylcatechol, TBC) and a monophenol (4-tert-butylphenol, TBP) has been determined.	Oxygen	21-27	TBC1 domain family member 1	Homo sapiens	118-121
12009413-1	2002	The stoichiometry of oxygen consumption during tyrosinase-catalyzed oxidation of an o-diphenol (4-tert-butylcatechol, TBC) and a monophenol (4-tert-butylphenol, TBP) has been determined.	Oxygen	21-27	TATA-box binding protein	Homo sapiens	161-164
11921358-5	2002	The expression of AM immunoreactivity is increased in cortical neurons, endothelial cells, and perivascular processes after a simulation of ischemia by oxygen and glucose deprivation.	Oxygen	152-158	adrenomedullin	Homo sapiens	18-20
11921362-5	2002	Given that most human epithelial cancers display a microenvironment of reduced oxygen tension, it is interesting to note that AM and several of its receptors are upregulated during hypoxic insult.	Oxygen	79-85	adrenomedullin	Homo sapiens	126-128
11914069-2	2002	As a member of the S100 protein family, Mts1 is predicted to contain four alpha-helices and two calcium-binding loops, the second of which forms a canonical EF hand, while the first is a pseudo-EF hand, using two extra residues and principally backbone carbonyls rather than side chain oxygens to coordinate calcium.	Oxygen	286-293	S100 calcium binding protein A4	Homo sapiens	40-44
12491240-6	2002	In particular, it has led to the development of new mechanistic notions about how non-heme multimetal enzymes, such as methane monooxygenases, fatty acid desaturase, and tyrosinase, may function in the activation of dioxygen to catalyze a diverse array of organic transformations.	Oxygen	216-224	stearoyl-CoA desaturase	Homo sapiens	143-164
12491240-6	2002	In particular, it has led to the development of new mechanistic notions about how non-heme multimetal enzymes, such as methane monooxygenases, fatty acid desaturase, and tyrosinase, may function in the activation of dioxygen to catalyze a diverse array of organic transformations.	Oxygen	216-224	tyrosinase	Homo sapiens	170-180
11920680-0	2002	Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1.	Oxygen	4-10	collagen type I alpha 1 chain	Homo sapiens	53-59
11920680-2	2002	We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming growth factor-beta1 (TGF-beta1) in human dermal fibroblasts.	Oxygen	42-44	collagen type I alpha 1 chain	Homo sapiens	150-156
11920680-2	2002	We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming growth factor-beta1 (TGF-beta1) in human dermal fibroblasts.	Oxygen	73-79	collagen type I alpha 1 chain	Homo sapiens	150-156
11920680-2	2002	We have previously shown that hypoxia (2% O2), when compared to standard oxygen tension (20% O2), upregulates the mRNA levels of the human alpha1(I) (COL1A1) procollagen gene and transforming growth factor-beta1 (TGF-beta1) in human dermal fibroblasts.	Oxygen	93-95	collagen type I alpha 1 chain	Homo sapiens	150-156
11921096-11	2002	The addition of glucose can also increase the sulphite formation in strains overexpressing MET14 and/or SSU1 under oxygen-limiting conditions, while the addition of glucose has no significant effect under aerobic conditions.	Oxygen	115-121	adenylyl-sulfate kinase	Saccharomyces cerevisiae S288C	91-96
11882815-8	2002	In the group of neonates, there were significant positive correlations between peak interleukin 10 serum levels and both partial pressure of arterial oxygen/fraction of inspired oxygen ratio and postoperative body weight gain.	Oxygen	150-156	interleukin 10	Homo sapiens	84-98
11882815-8	2002	In the group of neonates, there were significant positive correlations between peak interleukin 10 serum levels and both partial pressure of arterial oxygen/fraction of inspired oxygen ratio and postoperative body weight gain.	Oxygen	178-184	interleukin 10	Homo sapiens	84-98
11820779-14	2002	These data strongly support the notion that neuroglobin is a highly conserved gene in evolution and is very important in the nervous system, possibly related to the oxygen supply of the neuron.	Oxygen	165-171	neuroglobin	Homo sapiens	44-55
11802212-5	2002	PRL-induced killing of P815 target cells by EMs and TAMs was independent of TNF but correlated with the hormone-induced augmentation of NO2(-) and O2(-) release in these macrophages.	Oxygen	137-139	prolactin	Mus musculus	0-3
11719508-2	2002	We have asked whether also the vascular endothelial growth factor (VEGF) utilizes ROS as messenger intermediates downstream of the VEGF receptor-2 (VEGFR-2)/KDR receptor given that the proliferation of endothelial cells during neoangiogenesis is physiologically regulated by oxygen and likely by its derivative species.	Oxygen	275-281	kinase insert domain receptor	Homo sapiens	148-155
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Oxygen	32-38	aldo-keto reductase family 1 member C4	Homo sapiens	125-129
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Oxygen	32-38	placenta associated 8	Homo sapiens	264-268
12234095-1	2002	The mammalian EGLN family contains three paralagous genes (EGLN1, EGLN2, and EGLN3) encoding prolyl hydroxylase isoforms that mediate the oxygen-dependent targeting of the transcription factor hypoxia inducible factor alpha to the proteosome.	Oxygen	138-144	egl-9 family hypoxia inducible factor 3	Homo sapiens	77-82
12489116-0	2002	Overexpression of heme oxygenase-1 (HO-1) in V79 cells results in increased resistance to hyperbaric oxygen (HBO)-induced DNA damage.	Oxygen	23-29	heme oxygenase 1	Cricetulus griseus	36-40
12793918-10	2002	However, infants requiring supplemental oxygen at 36 wks of gestational age had reduced L-selectin at 24 hrs of age (3.2/2.0-3.45 vs. 5.0/2.35-10.4 nmol/L, p =.004), whereas there was no difference in ICAM-1.	Oxygen	40-46	intercellular adhesion molecule 1	Homo sapiens	201-207
16228552-4	2002	Both are under oxygen control, and disabling the fnrL gene abolishes induction of each promoter in response to lowering oxygen tension.	Oxygen	15-21	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	49-53
16228552-4	2002	Both are under oxygen control, and disabling the fnrL gene abolishes induction of each promoter in response to lowering oxygen tension.	Oxygen	120-126	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	49-53
11969358-2	2002	However, it also oxidizes hemoglobin to methemoglobin (metHgb), thereby reducing the delivery of oxygen to tissues.	Oxygen	97-103	hemoglobin subunit gamma 2	Homo sapiens	40-53
11805630-8	2002	RESULTS: With reduced oxygen delivery (lower arterial oxygen saturation and blood flow), oxygenated hemoglobin concentration decreased and deoxygenated hemoglobin concentration increased.	Oxygen	22-28	HGB	Sus scrofa	100-110
11805630-8	2002	RESULTS: With reduced oxygen delivery (lower arterial oxygen saturation and blood flow), oxygenated hemoglobin concentration decreased and deoxygenated hemoglobin concentration increased.	Oxygen	22-28	HGB	Sus scrofa	152-162
11726405-5	2001	With 5% oxygen, mRNA for ICAM-1 and VCAM-1 rose by 100%, peaking between 0.5 and 1 h. ICAM-1 and VCAM-1 protein showed an increase between 2 and 4 h. Neutrophil adherence to hypoxia-exposed AEC was enhanced by 115%.	Oxygen	8-14	intercellular adhesion molecule 1	Rattus norvegicus	25-31
11726405-5	2001	With 5% oxygen, mRNA for ICAM-1 and VCAM-1 rose by 100%, peaking between 0.5 and 1 h. ICAM-1 and VCAM-1 protein showed an increase between 2 and 4 h. Neutrophil adherence to hypoxia-exposed AEC was enhanced by 115%.	Oxygen	8-14	intercellular adhesion molecule 1	Rattus norvegicus	86-92
11719370-2	2001	In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-beta2), a cytokine with potent regulatory effects on vascular inflammatory responses.	Oxygen	85-90	transforming growth factor beta 2	Homo sapiens	137-169
11719370-2	2001	In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-beta2), a cytokine with potent regulatory effects on vascular inflammatory responses.	Oxygen	85-90	transforming growth factor beta 2	Homo sapiens	171-180
11745160-6	2001	Third, pressure measurements indicate that tyrosinase-coated chitosan films only react with cresol vapors if the oxygen cosubstrate is present.	Oxygen	113-119	tyrosinase	Homo sapiens	43-53
11740268-0	2001	Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.	Oxygen	0-6	HGB	Sus scrofa	39-49
11740268-1	2001	BACKGROUND: One of the perceived advantages of a hemoglobin-based blood substitute is the provision of oxygen-carrying capacity.	Oxygen	103-109	HGB	Sus scrofa	49-59
11740268-3	2001	We hypothesized that acellular hemoglobin solutions are useful oxygen carriers in anemic states and that higher P50 solutions transport O2 more efficiently than low P50 solutions.	Oxygen	63-69	HGB	Sus scrofa	31-41
11740268-4	2001	We sought to quantify O2 transport dynamics of hemoglobin solutions in an isovolemic hemodilution model in swine.	Oxygen	22-24	HGB	Sus scrofa	47-57
11740268-11	2001	Oxygen extraction ratio increased with progressive hemodilution in both the RBC hemoglobin and plasma phases to a maximum of 39% for PHP and 36% for POE-Hb at Hct = 8%.	Oxygen	0-6	HGB	Sus scrofa	80-90
11740268-13	2001	CONCLUSION: Acellular hemoglobin solutions provide a significant contribution to O2 delivery and consumption, particularly in severe anemia, in this model of isovolemic exchange.	Oxygen	81-83	HGB	Sus scrofa	22-32
11546758-3	2001	Fluorescence kinetics, oxygen flash yield, and thermoluminescence measurements indicate that inactivation of the psbJ gene in Synechocystis 6803 cells and tobacco chloroplasts lowers PSII-mediated oxygen evolution activity and increases the lifetime of the reduced primary acceptor Q(A)(-) (more than a 100-fold in the tobacco DeltapsbJ mutant).	Oxygen	23-29	photosystem II reaction center subunit X	Nicotiana tabacum	113-117
11546758-3	2001	Fluorescence kinetics, oxygen flash yield, and thermoluminescence measurements indicate that inactivation of the psbJ gene in Synechocystis 6803 cells and tobacco chloroplasts lowers PSII-mediated oxygen evolution activity and increases the lifetime of the reduced primary acceptor Q(A)(-) (more than a 100-fold in the tobacco DeltapsbJ mutant).	Oxygen	197-203	photosystem II reaction center subunit X	Nicotiana tabacum	113-117
11600411-1	2001	Myoglobin is a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers and facilitates oxygen delivery during periods of high metabolic demand.	Oxygen	125-131	myoglobin	Mus musculus	0-9
11722568-9	2001	Although P. furiosus is a strict anaerobe, it may tolerate oxygen to some extent and we anticipate NOX1 to be involved in the response to oxygen at high temperatures.	Oxygen	138-144	NADPH oxidase 1	Rattus norvegicus	99-103
11641274-6	2001	Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration.	Oxygen	196-200	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	39-44
11473111-2	2001	Neuroglobin (Ngb) is a newly discovered oxygen-binding heme protein that is primarily expressed in the brain of humans and other vertebrates.	Oxygen	40-46	neuroglobin	Homo sapiens	0-11
11473111-2	2001	Neuroglobin (Ngb) is a newly discovered oxygen-binding heme protein that is primarily expressed in the brain of humans and other vertebrates.	Oxygen	40-46	neuroglobin	Homo sapiens	13-16
11563840-5	2001	Compared to exposure to 20 and 5% oxygen, exposure to 1% oxygen decreased adhesion of these cells to vitronectin and fibronectin, an effect that was reversible by re-exposure to 20% oxygen.	Oxygen	57-63	vitronectin	Homo sapiens	101-112
11563840-5	2001	Compared to exposure to 20 and 5% oxygen, exposure to 1% oxygen decreased adhesion of these cells to vitronectin and fibronectin, an effect that was reversible by re-exposure to 20% oxygen.	Oxygen	57-63	vitronectin	Homo sapiens	101-112
11554819-1	2001	(4S)-tert-Butyl 2,2-dioxo-3-PhF-1,2,3-oxathiazainane-4-carboxylate reacted effectively with nitrogen, sulfur, and oxygen nucleophiles to provide enantiopure (&gt;97% ee) gamma-substituted alpha-amino acids.	Oxygen	114-120	PHD finger protein 1	Homo sapiens	28-33
11448968-8	2001	The inability to grow on raffinose is not caused by the cell iron content being too low to sustain respiratory metabolism, because the oxygen consumption of aft1 mutants showed that their respiratory activity is 2-fold higher than that of controls.	Oxygen	135-141	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	157-161
11448968-9	2001	The double aft1aft2 mutant also has many phenotypes related to oxidative stress such as H(2)O(2) hypersensitivity, oxygen-dependent copper toxicity, and oxygen-dependent methionine auxotrophy, which are suppressed in anaerobiosis.	Oxygen	115-121	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	11-19
11448968-9	2001	The double aft1aft2 mutant also has many phenotypes related to oxidative stress such as H(2)O(2) hypersensitivity, oxygen-dependent copper toxicity, and oxygen-dependent methionine auxotrophy, which are suppressed in anaerobiosis.	Oxygen	153-159	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	11-19
11532868-9	2001	The results suggest that the consequences of an Ogg1 defect are restricted to slowly proliferating tissues with high oxygen metabolism such as liver, because of a back-up mechanism for the repair of 8-oxoG residues that is independent of transcription and replication.	Oxygen	117-123	8-oxoguanine DNA-glycosylase 1	Mus musculus	48-52
11513762-6	2001	Oxygen cost of breathing was defined as the difference in V(O(2)) (Delta V(O(2))) during the trial of reduced mechanical ventilatory support, compared to a 30-minute resting period immediately before the trial.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	67-80
11523016-5	2001	COHORTS AND METHODS: In 100 healthy athletic men (aged 36 +/- 6.2 years) transcutaneous penile oxygen pressure (tpO (2)) at the glans penis was measured during cycling in different positions and with different types of saddle, using a modified Clark oxygen electrode.	Oxygen	95-101	thyroid peroxidase	Homo sapiens	112-115
11413138-1	2001	The phagocyte NADPH-dependent oxidase generates superoxide (O(2)) by reducing molecular oxygen through flavocytochrome b(558) (flavocytochrome b), a heterodimeric oxidoreductase composed of gp91(phox) and p22(phox) subunits.	Oxygen	88-94	thioredoxin reductase 1	Homo sapiens	163-177
11506694-7	2001	Partial pressure of oxygen (PaO2) levels in the hIL-10 group (6 hr of CIT) were higher than in empty vector and diluent groups (PaO2, 530 +/- 23 vs. 387 +/- 31 and 439 +/- 27 mmHg, respectively, p &lt; 0.05).	Oxygen	20-26	interleukin 10	Homo sapiens	48-54
11371554-0	2001	Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation.	Oxygen	151-153	retinoid X receptor alpha	Homo sapiens	70-89
11344164-8	2001	Finally, we have used Zn(2+) treatment as a maneuver able to discriminate between these two homologues of hTASK and show that the most likely candidate channel for O(2) sensing in these cells is hTASK3.	Oxygen	164-168	potassium two pore domain channel subfamily K member 9	Homo sapiens	195-201
11404258-2	2001	The current study tested the hypothesis that hypoxia-responsive growth factors, fibroblast growth factors (FGF-1 and FGF-2) and platelet-derived growth factor-BB (PDGF-BB), that activate tyrosine kinase receptors can reduce expression of NPR-C in PASMCs independent of environmental oxygen tension.	Oxygen	283-289	fibroblast growth factor 1	Rattus norvegicus	107-112
11442337-7	2001	cAMP was added at 0.1 mM to cultures, and the selenoprotein P mRNA expression and testosterone concentration were evaluated after incubation times of 2, 5, 9, 15, or 24 h. Selenoprotein P mRNA expression was maximal at 9 h. Testosterone concentration in the medium also increased, becoming maximal at 15 h. Selenoprotein P induced in Leydig cells following cAMP stimulation may counteract O2 toxicity from cAMP-mediated increases in testosterone production.	Oxygen	389-391	selenoprotein P	Mus musculus	172-187
11510809-4	2001	Inspired oxygen fraction (FI,O2) was varied (0.21, 0.3, 0.5, 0.75 and 1.0) among tests in a randomized order.	Oxygen	9-15	immunoglobulin kappa variable 1D-39	Homo sapiens	26-31
11516148-0	2001	Methylation of the Opaque2 box in zein genes is parent-dependent and affects O2 DNA binding activity in vitro.	Oxygen	77-79	regulatory protein opaque-2	Zea mays	19-26
11375681-8	2001	The molecule possesses syn-syn conformation (both C=O bonds synperiplanar to the O-O bond) with O-O = 1.426(10) A and dihedral angle phi(C-O-O-C) = 86.5(32) degrees.	Oxygen	81-84	synemin	Homo sapiens	23-26
11375681-8	2001	The molecule possesses syn-syn conformation (both C=O bonds synperiplanar to the O-O bond) with O-O = 1.426(10) A and dihedral angle phi(C-O-O-C) = 86.5(32) degrees.	Oxygen	81-84	synemin	Homo sapiens	27-30
11399714-1	2001	BACKGROUND: Correcting the decrease in oxygen delivery from anemia using allogeneic RBC transfusions has been hypothesized to help with increased oxygen demands during weaning from mechanical ventilation.	Oxygen	39-45	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	84-87
11399714-1	2001	BACKGROUND: Correcting the decrease in oxygen delivery from anemia using allogeneic RBC transfusions has been hypothesized to help with increased oxygen demands during weaning from mechanical ventilation.	Oxygen	146-152	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	84-87
11348143-6	2001	The regioselective attack of SDE to the central oxygen of the ozonide was supported by the quantum chemical calculation (B3LYP/6-31G).	Oxygen	48-54	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	123-126
11336512-7	2001	These results, together with the placental defects previously observed in VHL(-/-) mice, suggest that pVHL is a component of the mechanism that transduces local differences in oxygen tension at the maternal-fetal interface to changes in the biological behavior of cytotrophoblasts.	Oxygen	176-182	von Hippel-Lindau tumor suppressor	Mus musculus	102-106
11304494-6	2001	These data reveal that myoglobin is necessary to support cardiac function during development, but adaptive responses evoked in some animals can fully compensate for the defect in cellular oxygen transport resulting from the loss of myoglobin.	Oxygen	188-194	myoglobin	Mus musculus	232-241
11287144-5	2001	Relative activities of two yeast acylCoA:sterol acyltransferases (Are1p and Are2p) changed in response to anaerobiosis: while Are2p was dominant under aerobic conditions, Are1p provided the major activity in the absence of oxygen.	Oxygen	223-229	sterol acyltransferase	Saccharomyces cerevisiae S288C	66-71
11287144-5	2001	Relative activities of two yeast acylCoA:sterol acyltransferases (Are1p and Are2p) changed in response to anaerobiosis: while Are2p was dominant under aerobic conditions, Are1p provided the major activity in the absence of oxygen.	Oxygen	223-229	sterol acyltransferase	Saccharomyces cerevisiae S288C	171-176
11290707-9	2001	Furthermore, oxygen repression of the hypoxic HEM13 gene was not affected by the deletion nor was this putative ROX1 gene regulated positively by oxygen as is the case for the S. cerevisiae gene.	Oxygen	13-19	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	46-51
11332029-2	2001	The singlet-oxygen quenching constants for GRP-carotenal were 1.3 +/- 0.1 x 10(10) and 1.0 +/- 0.1 x 10(10) M-1 s-1 in acetonitrile and in detergent micelles, respectively.	Oxygen	12-18	gastrin releasing peptide	Homo sapiens	43-46
11332029-9	2001	Singlet-oxygen quenching by GRP-carotenal and by beta-apo-8"-carotenal were roughly the same.	Oxygen	8-14	gastrin releasing peptide	Homo sapiens	28-31
11345558-3	2001	Initial treatment of AAA should be made as early as possible and should associate high-dose oxygen, nebulisations of beta-2-agonists and corticosteroid infusion.	Oxygen	92-98	AAA1	Homo sapiens	21-24
11262101-5	2001	The rotational rate and syn/anti ratio, which indicate the orientation between carbonyl oxygen and hydrogen at the 4-position, are significantly affected by addition of magnesium ion.	Oxygen	88-94	synemin	Homo sapiens	24-27
11262118-3	2001	The stereochemical outcome of the IMDAF cycloaddition has the side arm of the tethered alkenyl group oriented syn with respect to the oxygen bridge.	Oxygen	134-140	synemin	Homo sapiens	110-113
11327636-4	2001	RESULTS: We found that hypoxic conditions (1-3% oxygen) significantly increased adrenomedullin mRNA and protein in HUVEC.	Oxygen	48-54	adrenomedullin	Homo sapiens	80-94
11327636-5	2001	This increase was inversely proportional to oxygen tension and was reversible upon re-exposure to a 21% oxygen environment Nuclear run-off experiments revealed the enhanced transcriptional rate of adrenomedullin gene.	Oxygen	44-50	adrenomedullin	Homo sapiens	197-211
11327636-5	2001	This increase was inversely proportional to oxygen tension and was reversible upon re-exposure to a 21% oxygen environment Nuclear run-off experiments revealed the enhanced transcriptional rate of adrenomedullin gene.	Oxygen	104-110	adrenomedullin	Homo sapiens	197-211
11317144-15	2001	However, the increase in fat oxidation in RE2 only accounted for approximately 20% of the extra oxygen cost of running (RE2 vs RE3).	Oxygen	96-102	G protein-coupled receptor 161	Homo sapiens	42-45
11317144-15	2001	However, the increase in fat oxidation in RE2 only accounted for approximately 20% of the extra oxygen cost of running (RE2 vs RE3).	Oxygen	96-102	G protein-coupled receptor 161	Homo sapiens	120-123
11226224-2	2001	In 1957, Bloch and colleagues identified a factor from rat liver cytosol termed "supernatant protein factor (SPF)," which promotes the squalene epoxidation catalyzed by rat liver microsomes with oxygen, NADPH, FAD, and phospholipid [Tchen, T. T. &amp; Bloch, K. (1957) J. Biol.	Oxygen	195-201	SEC14-like lipid binding 2	Rattus norvegicus	80-107
11226224-2	2001	In 1957, Bloch and colleagues identified a factor from rat liver cytosol termed "supernatant protein factor (SPF)," which promotes the squalene epoxidation catalyzed by rat liver microsomes with oxygen, NADPH, FAD, and phospholipid [Tchen, T. T. &amp; Bloch, K. (1957) J. Biol.	Oxygen	195-201	SEC14-like lipid binding 2	Rattus norvegicus	109-112
11471076-1	2001	Carbon tetrachloride (CCl4) has been found to induce cellular damage by generating oxygen free radicals.	Oxygen	83-89	chemokine (C-C motif) ligand 4	Mus musculus	22-26
21171452-0	2001	[Study on the effect of hyperbaric oxygen on apoptosis in the CA1 region of hippocampus following forebrain ischemia reperfusion].	Oxygen	35-41	carbonic anhydrase 1	Homo sapiens	62-65
11950144-6	2001	Since hypoxia induces HIF in other tissues, systemic hypoxia (6% O2 for 4.5 h) was also shown to increase HIF-1alpha protein expression in the adult rat brain.	Oxygen	65-67	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	106-116
16233000-6	2001	Using the PHO5 gene fusion as a reporter, we have identified several cis- and trans-acting genes of S. cerevisiae which are involved in splicing of pre-mRNA, biosynthesis of amino acids, ubiquitin-dependent protein degradation, signal transduction of oxygen and unsaturated fatty acid, regulation of transcription by the nucleosome and chromatin.	Oxygen	251-257	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	10-14
11380194-2	2001	Our study shows that a combination of ultrasonic pretreatment and biodegradation effectively removes the solvent chlorobenzene and the disinfectant 2,4-dichlorophenol, also reduces Adsorbable Organic Halogens (AOX) and Chemical Oxygen Demand (COD).	Oxygen	228-234	acyl-CoA oxidase 1	Homo sapiens	210-213
11151515-0	2000	Formation and structure of the oxygen-centered lead thiolate cluster Pb5O(SRF)8.2C7H8 [RF = 2,4,6-tris(trifluoromethyl)phenyl].	Oxygen	31-37	serum response factor	Homo sapiens	74-77
10988296-3	2000	In confluent fibroblast cultures, the decrease in the concentration of oxygen species was associated with diminished activity of the small GTPase Rac-1, a signal transducer directly involved in the ligand-dependent generation of oxygen-derived molecules, and was effectively mimicked by exposure of sparse cultures to dithiothreitol (DTT) and inhibitors of enzymes (phospholipase A2 and lipoxygenase) acting in the arachidonic acid cascade downstream of growth factor receptors and Rac-1.	Oxygen	71-77	Rac family small GTPase 1	Homo sapiens	146-151
10988296-3	2000	In confluent fibroblast cultures, the decrease in the concentration of oxygen species was associated with diminished activity of the small GTPase Rac-1, a signal transducer directly involved in the ligand-dependent generation of oxygen-derived molecules, and was effectively mimicked by exposure of sparse cultures to dithiothreitol (DTT) and inhibitors of enzymes (phospholipase A2 and lipoxygenase) acting in the arachidonic acid cascade downstream of growth factor receptors and Rac-1.	Oxygen	71-77	Rac family small GTPase 1	Homo sapiens	482-487
10988296-3	2000	In confluent fibroblast cultures, the decrease in the concentration of oxygen species was associated with diminished activity of the small GTPase Rac-1, a signal transducer directly involved in the ligand-dependent generation of oxygen-derived molecules, and was effectively mimicked by exposure of sparse cultures to dithiothreitol (DTT) and inhibitors of enzymes (phospholipase A2 and lipoxygenase) acting in the arachidonic acid cascade downstream of growth factor receptors and Rac-1.	Oxygen	229-235	Rac family small GTPase 1	Homo sapiens	146-151
11140697-4	2000	Adult mice exposed to greater than 95% oxygen concentrations for 48 to 88 hours had increased whole-lung mRNA levels of Bax and Bcl-X(L), no change in Bak, Bad, or Bcl-2, and decreased levels of Bcl-w and Bfl-1.	Oxygen	39-45	BCL2-associated X protein	Mus musculus	120-123
11140697-4	2000	Adult mice exposed to greater than 95% oxygen concentrations for 48 to 88 hours had increased whole-lung mRNA levels of Bax and Bcl-X(L), no change in Bak, Bad, or Bcl-2, and decreased levels of Bcl-w and Bfl-1.	Oxygen	39-45	BCL2-like 2	Mus musculus	195-200
11076596-10	2000	Attack at the C-14 ring junction is in concert with the proposal that electrophilic oxygen would attack at C-14/C-15 (epoxidation) followed by ring opening to give the biologically active 15-ol as a major metabolite.	Oxygen	84-90	placenta associated 8	Homo sapiens	107-116
11046005-9	2000	The oxygen-dependent step in Dex-induced apoptosis lies upstream of caspase-3-like protease activation.	Oxygen	4-10	caspase 3	Mus musculus	68-77
11090916-5	2000	In lung explants from O2-treated animals, all BPD animals responded to 1nM bombesin, whereas non-BPD animals did not; the opposite effect was observed with a BLP blocking antibody.	Oxygen	22-24	dynein light chain roadblock-type 1	Homo sapiens	158-161
11023552-4	2000	Retinal VEGF mRNA levels were measured in a murine model of oxygen-induced retinopathy during vaso-obliterative and hypoxic phases.	Oxygen	60-66	vascular endothelial growth factor A	Mus musculus	8-12
11029004-5	2000	Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue.	Oxygen	69-75	neuroglobin	Homo sapiens	24-35
10988074-5	2000	While this conformation allows endoperoxide formation between C-11 and C-9, it also implies that a subsequent conformational rearrangement must occur to allow formation of the C-8/C-12 bond and to position C-15 for attack by a second molecule of oxygen.	Oxygen	246-252	complement C9	Homo sapiens	71-74
10978164-4	2000	The results suggest that, in addition to stabilizing the reactive intermediate compound I, the distal arginine plays an important role as a gatekeeper in the active site of CCP, controlling the access to the ferryl oxygen and the distal histidine.	Oxygen	215-221	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	173-176
10986432-7	2000	The placentas from such cases show a deficit in peripheral villous development, which may be perpetuated by the effects of oxygen (delivered by maternal blood into the intervillous space) upon VEGF-directed angiogenesis, the so-called "placental hyperoxia" theory of villous maldevelopment.	Oxygen	123-129	vascular endothelial growth factor A	Mus musculus	193-197
10926859-0	2000	Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem.	Oxygen	0-6	catalase A	Saccharomyces cerevisiae S288C	64-74
10924349-2	2000	We demonstrate that in vitro the Na(+)/K(+)-ATPase, a non heme-protein, is able to disproportionate H(2)O(2) catalatically into dioxygen and water, as well as C(40) catalase.	Oxygen	128-136	immunoglobulin kappa variable 1D-39	Homo sapiens	104-108
10913374-8	2000	We suppose that the high Hsp70 under these conditions reflects a stress response which disappears at the more physiological reduced oxygen tension during hypoxia.	Oxygen	132-138	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
10893218-2	2000	We investigated lung PTHrP expression in rats exposed to 85% oxygen.	Oxygen	61-67	parathyroid hormone-like hormone	Rattus norvegicus	21-26
10893218-8	2000	Thus PTHrP expression changes in response to lung injury due to 85% oxygen and may regulate cell proliferation.	Oxygen	68-74	parathyroid hormone-like hormone	Rattus norvegicus	5-10
10891467-4	2000	During hypoxia (11% O(2)), only sickle mice converted tissue xanthine dehydrogenase to oxidase.	Oxygen	20-24	xanthine dehydrogenase	Mus musculus	61-83
11005571-3	2000	The hypothesis that HGF/SF alters the energy metabolism of cancer cells was investigated in perfused DA3 murine mammary cancer cells by nuclear magnetic resonance (NMR) spectroscopy, oxygen and glucose consumption assays and confocal laser scanning microscopy (CLSM).	Oxygen	183-189	hepatocyte growth factor	Mus musculus	20-26
11005571-6	2000	In addition, HGF/SF treatment increased oxygen consumption from 0.58+/-0.02 to 0.71+/-0.03 micromol/hour per milligram protein (P &lt; .05).	Oxygen	40-46	hepatocyte growth factor	Mus musculus	13-19
10843633-6	2000	The most favorable pathway takes place along an endo/syn approach of the furan ring relative to the bridged oxygen atom of the oxanorbornadiene system, with participation of the substituted double bond.	Oxygen	108-114	synemin	Homo sapiens	53-56
10950305-2	2000	Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria [1-3].	Oxygen	155-161	myoglobin	Mus musculus	0-9
10843784-2	2000	The glutathione modified aldose reductase generated in the lens as a consequence of hyperbaric oxygen treatment was recovered in its reduced form following culturing in normobaric air conditions.	Oxygen	95-101	aldose reductase	Bos taurus	25-41
10847587-0	2000	Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.	Oxygen	107-113	adrenomedullin	Homo sapiens	48-62
10847587-2	2000	We demonstrate here that the expression of AM mRNA in a variety of human tumor cell lines is highly induced in a time-dependent manner by reduced oxygen tension (1% O2) or exposure to hypoxia mimetics such as desferrioxamine mesylate (DFX) or CoCl2.	Oxygen	146-152	adrenomedullin	Homo sapiens	43-45
10847587-2	2000	We demonstrate here that the expression of AM mRNA in a variety of human tumor cell lines is highly induced in a time-dependent manner by reduced oxygen tension (1% O2) or exposure to hypoxia mimetics such as desferrioxamine mesylate (DFX) or CoCl2.	Oxygen	165-167	adrenomedullin	Homo sapiens	43-45
10801284-10	2000	Insulin infusion for 8 days during Epi infusion or for 4 days during NE infusion decreased arterial blood pressure, O(2) content, and plasma glucose, but increased heart rate significantly (all P &lt;0.05), despite continuation of Epi or NE infusion.	Oxygen	116-120	LOC105613195	Ovis aries	0-7
10900719-1	2000	Progressive hypoxia and cell destruction leading to increased production of active oxygen forms by xanthinoxidase and manifesting by an increased level of uric acid in the blood in parallel with inhibited pentose cycle reaction due to low activity of glucose-6-phosphate dehydrogenase determine the severity of peritonitis.	Oxygen	83-89	glucose-6-phosphate dehydrogenase	Homo sapiens	251-284
10806382-14	2000	The participation of cytochrome c550 in mitochondrial electron transport from succinate to oxygen was shown by spectral measurements.	Oxygen	91-97	cytochrome c	Sus scrofa	21-33
10759599-1	2000	Myoglobin (Mb) is a large protein that reversibly binds oxygen in the muscle cell and is thought to be critical for O2 supply to the mitochondria during exercise.	Oxygen	56-62	myoglobin	Mus musculus	0-9
10759599-1	2000	Myoglobin (Mb) is a large protein that reversibly binds oxygen in the muscle cell and is thought to be critical for O2 supply to the mitochondria during exercise.	Oxygen	56-62	myoglobin	Mus musculus	11-13
10759599-1	2000	Myoglobin (Mb) is a large protein that reversibly binds oxygen in the muscle cell and is thought to be critical for O2 supply to the mitochondria during exercise.	Oxygen	116-118	myoglobin	Mus musculus	0-9
10759599-1	2000	Myoglobin (Mb) is a large protein that reversibly binds oxygen in the muscle cell and is thought to be critical for O2 supply to the mitochondria during exercise.	Oxygen	116-118	myoglobin	Mus musculus	11-13
10759599-5	2000	However, the quantitative role of Mb in "facilitated" or parallel diffusion of O2 is controversial.	Oxygen	79-81	myoglobin	Mus musculus	34-36
10759599-8	2000	Thus, the current evidence supports the role of Mb in the physical diffusion of O2; however, the unimpaired aerobic function of Mb knockout mice indicates that this role may not be critical to O2 supply in active muscle.	Oxygen	80-82	myoglobin	Mus musculus	48-50
10757164-5	2000	The mechanism responsible for this difference in behavior of lyso-GPC subtypes was consistent with a higher proton affinity of carboxyl carbonyl oxygen atoms and vinyl ether oxygen atoms found in acyl and plasmenyl lyso-GPC lipids, respectively, as compared to the carbinol oxygen atom common to all lyso-GPC species.	Oxygen	145-151	glycophorin C (Gerbich blood group)	Homo sapiens	66-69
10757164-5	2000	The mechanism responsible for this difference in behavior of lyso-GPC subtypes was consistent with a higher proton affinity of carboxyl carbonyl oxygen atoms and vinyl ether oxygen atoms found in acyl and plasmenyl lyso-GPC lipids, respectively, as compared to the carbinol oxygen atom common to all lyso-GPC species.	Oxygen	174-180	glycophorin C (Gerbich blood group)	Homo sapiens	66-69
10757164-5	2000	The mechanism responsible for this difference in behavior of lyso-GPC subtypes was consistent with a higher proton affinity of carboxyl carbonyl oxygen atoms and vinyl ether oxygen atoms found in acyl and plasmenyl lyso-GPC lipids, respectively, as compared to the carbinol oxygen atom common to all lyso-GPC species.	Oxygen	174-180	glycophorin C (Gerbich blood group)	Homo sapiens	66-69
10809177-10	2000	The corresponding values for unbound intrinsic clearances (CLu,int) for antipyrine, ethanol, lidocaine and oxygen were: 1.6, 31.0, 158.0 and 27.5 ml/min, respectively.	Oxygen	107-113	clusterin	Rattus norvegicus	59-62
10692397-0	2000	Coordinate copper- and oxygen-responsive Cyc6 and Cpx1 expression in Chlamydomonas is mediated by the same element.	Oxygen	23-29	uncharacterized protein	Chlamydomonas reinhardtii	50-54
10788918-8	2000	T test (SSPS 7.5) showed significant improvement per day after topical hyperbaric oxygen therapy, t = 5.217, df = 24, P &lt; 0.0001 (95% CI = 1.13-0.49).	Oxygen	82-88	Wnt family member 10A	Homo sapiens	8-12
10690527-7	2000	In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen.	Oxygen	143-149	HIG1 hypoxia inducible domain family member 1A pseudogene 1	Homo sapiens	103-107
10751034-1	2000	PURPOSE: We examined the metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF) using the Cu(II)/ascorbate/O2 model oxidative system.	Oxygen	122-124	brain derived neurotrophic factor	Homo sapiens	54-87
10751034-1	2000	PURPOSE: We examined the metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF) using the Cu(II)/ascorbate/O2 model oxidative system.	Oxygen	122-124	brain derived neurotrophic factor	Homo sapiens	89-93
10751034-4	2000	RESULTS: Exposure of BDNF to the Cu(II)/ascorbate/O2 system led to the modification of ca.	Oxygen	50-52	brain derived neurotrophic factor	Homo sapiens	21-25
10027076-0	1999	Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin.	Oxygen	111-117	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	0-28
9888442-2	1999	HIF-1 transactivates multiple genes whose products play key roles in oxygen homeostasis, including vascular endothelial growth factor (VEGF).	Oxygen	69-75	vascular endothelial growth factor A	Mus musculus	99-133
9888442-2	1999	HIF-1 transactivates multiple genes whose products play key roles in oxygen homeostasis, including vascular endothelial growth factor (VEGF).	Oxygen	69-75	vascular endothelial growth factor A	Mus musculus	135-139
10477134-2	1999	Treatment with hypoxia (5% CO2/94% N2/1% O2) for 6 and 12 h increased expression levels of ADM mRNA 2.2-fold and fivefold compared with the normoxia control, respectively.	Oxygen	28-30	adrenomedullin	Homo sapiens	91-94
9851827-1	1998	The leukocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyzes the production of O-2 from oxygen using NADPH as the electron donor.	Oxygen	112-118	immunoglobulin kappa variable 1D-39	Homo sapiens	103-106
10050328-1	1998	Oxygen regimen of the organism was experimentally studied at the stages of oxygen entry, transport, and consumption in severe exotoxigenic shock caused by poisoning with methemoglobin-forming toxin during correction of this state by different intensive care methods.	Oxygen	0-6	hemoglobin subunit gamma 2	Homo sapiens	170-183
9799562-4	1998	The stoichiometry of iron oxidation and oxygen consumption during iron loading into ferritin by the tissue-derived oxidase and serum ceruloplasmin were 3.6 +/- 0.2 and 3.9 +/- 0.2, respectively.	Oxygen	40-46	ceruloplasmin	Equus caballus	133-146
9804424-1	1998	Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand.	Oxygen	129-135	myoglobin	Mus musculus	0-9
9804424-1	1998	Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand.	Oxygen	155-161	myoglobin	Mus musculus	0-9
9804424-2	1998	Here we show, however, that mice without myoglobin, generated by gene-knockout technology, are fertile and exhibit normal exercise capacity and a normal ventilatory response to low oxygen levels (hypoxia).	Oxygen	181-187	myoglobin	Mus musculus	41-50
11672368-5	1998	This implies that the alkoxy oxygen in anti-3 is a much poorer hydrogen bond acceptor than the carbonyl oxygen in syn-3, most likely because of a combination of steric and electrostatic factors.	Oxygen	29-35	synemin	Homo sapiens	114-117
11672368-5	1998	This implies that the alkoxy oxygen in anti-3 is a much poorer hydrogen bond acceptor than the carbonyl oxygen in syn-3, most likely because of a combination of steric and electrostatic factors.	Oxygen	104-110	synemin	Homo sapiens	114-117
9805254-8	1998	Based on these measurements, we calculated the arteriovenous oxygen difference (c(A-V)O2 difference) during exercise in individual patients using Fick"s equation.	Oxygen	61-67	carbonic anhydrase 5A	Homo sapiens	80-88
9805254-9	1998	The c(A-V)O2 difference was markedly increased in severe heart failure during the warm-up stage, but between the end of warm-up and the AT point, it remained at the same level as that of group H. These results suggest the presence of a unique mechanism regulating the c(A-V)O2 difference in severe heart failure patients, activation of which may, at least during mild exercise, contribute to efficient oxygen delivery to the peripheral tissues thus compensating for the jeopardized exercise tolerance in those patients.	Oxygen	402-408	carbonic anhydrase 5A	Homo sapiens	4-12
9805254-9	1998	The c(A-V)O2 difference was markedly increased in severe heart failure during the warm-up stage, but between the end of warm-up and the AT point, it remained at the same level as that of group H. These results suggest the presence of a unique mechanism regulating the c(A-V)O2 difference in severe heart failure patients, activation of which may, at least during mild exercise, contribute to efficient oxygen delivery to the peripheral tissues thus compensating for the jeopardized exercise tolerance in those patients.	Oxygen	402-408	carbonic anhydrase 5A	Homo sapiens	268-276
9858048-2	1998	A cell membrane localised non-mitochondrial cytochrome b558 seems to be involved as an oxygen sensor in the hepatoma cell line HepG2 in cooperation with the mitochondrial cytochrome b563 probably probing additionally metabolic changes.	Oxygen	87-93	mitochondrially encoded cytochrome b	Homo sapiens	44-56
9748657-1	1998	The leukocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyzes the production of O-2 from oxygen using NADPH as the electron donor.	Oxygen	112-118	immunoglobulin kappa variable 1D-39	Homo sapiens	103-106
9707645-10	1998	Nonsymbiotic hemoglobins are likely ancestors of an early form of hemoglobin that sequestered oxygen in low oxygen environments, providing a source of oxygen to oxidize NADH to provide ATP for cell growth and development.	Oxygen	94-100	non-symbiotic hemoglobin	Zea mays	13-23
9707645-10	1998	Nonsymbiotic hemoglobins are likely ancestors of an early form of hemoglobin that sequestered oxygen in low oxygen environments, providing a source of oxygen to oxidize NADH to provide ATP for cell growth and development.	Oxygen	108-114	non-symbiotic hemoglobin	Zea mays	13-23
9707645-10	1998	Nonsymbiotic hemoglobins are likely ancestors of an early form of hemoglobin that sequestered oxygen in low oxygen environments, providing a source of oxygen to oxidize NADH to provide ATP for cell growth and development.	Oxygen	108-114	non-symbiotic hemoglobin	Zea mays	13-23
9745867-7	1998	The effect of 100KF on glomerular ecto-ATPase was oxygen dependent (32.98+/-2.14 under air vs. 65.20+/-5.53 under nitrogen, P&lt; or =0.01), in contrast to the 100KF-induced loss of glomerular sialoglycoproteins that was not significantly altered under nitrogen (62.67+/-10.08 under air vs. 61.74+/-26.05 under nitrogen).	Oxygen	50-56	CEA cell adhesion molecule 1	Rattus norvegicus	34-45
9745867-8	1998	Supplementation of SOD to 100KF solution under normal incubation conditions also suggested oxygen-dependent impairment of glomerular ecto-ATPase.	Oxygen	91-97	CEA cell adhesion molecule 1	Rattus norvegicus	133-144
9708893-4	1998	Reexamination of thio effects with substrates having a GUA triplet at the cleavage site shows that, in agreement with the previous finding, the cleavage rate, in the presence of Mg2+ ions, is significantly reduced in the case of the phosphorothioate substrate (RpS), wherein the pro-Rp oxygen at the scissile phosphate is replaced by sulfur, while the cleavage rate is reduced to a much lesser extent for the other isomer (SpS), wherein the pro-Sp oxygen at the scissile phosphate is replaced by sulfur.	Oxygen	448-454	protein only RNase P catalytic subunit	Homo sapiens	279-285
9708893-6	1998	These results argue against the previous conclusion that a metal ion is directly coordinating with the pro-Rp oxygen of the scissile phosphate to stabilize the transition state.	Oxygen	110-116	protein only RNase P catalytic subunit	Homo sapiens	103-109
9651380-6	1998	Exposure of cultured adult rat ventricular cardiac myocytes to hypoxia (1% O2) resulted in a significant, time-dependent increase in adrenomedullin mRNA levels.	Oxygen	75-77	adrenomedullin	Rattus norvegicus	133-147
9653127-7	1998	Conversely, the ODD domain alone confers oxygen-dependent instability when fused to a stable protein, Gal4.	Oxygen	41-47	galectin 4	Homo sapiens	102-106
9740377-6	1998	Consistent with these structural and conformational analyses, the TgHbA also exhibits complete functional equivalence with the human-derived HbA with respect to oxygen affinity, cooperativity, Bohr effect and allostery.	Oxygen	161-167	sodium voltage-gated channel alpha subunit 2	Homo sapiens	68-71
9693739-4	1998	The oxygen pressure at 50% of maximum flux, p50, was 0.035 and 0.057 kPa in heart and liver mitochondria, respiring in state 3 on substrates for complex I or II and II, respectively.	Oxygen	4-10	activating signal cointegrator 1 complex subunit 1	Homo sapiens	44-47
9693739-6	1998	The apparent kinetic efficiency, Jmax/p50, increased from the resting to the active state, despite the decrease of oxygen affinity, 1/p50.	Oxygen	115-121	activating signal cointegrator 1 complex subunit 1	Homo sapiens	38-41
9693739-6	1998	The apparent kinetic efficiency, Jmax/p50, increased from the resting to the active state, despite the decrease of oxygen affinity, 1/p50.	Oxygen	115-121	activating signal cointegrator 1 complex subunit 1	Homo sapiens	134-137
9609733-11	1998	Exposure to &gt;95% oxygen, when initiated on postnatal day 2 or 3 and continued until day 11, significantly diminished the developmental increase in tropoelastin hnRNA (P &lt; 0.005) and mRNA (P &lt; 0.05) normally seen on days 9-11, indicating that the postnatal upregulation of tropoelastin gene expression is inhibited by hyperoxic exposure in the early postnatal period.	Oxygen	20-26	elastin	Rattus norvegicus	150-162
9609733-11	1998	Exposure to &gt;95% oxygen, when initiated on postnatal day 2 or 3 and continued until day 11, significantly diminished the developmental increase in tropoelastin hnRNA (P &lt; 0.005) and mRNA (P &lt; 0.05) normally seen on days 9-11, indicating that the postnatal upregulation of tropoelastin gene expression is inhibited by hyperoxic exposure in the early postnatal period.	Oxygen	20-26	elastin	Rattus norvegicus	281-293
9747440-1	1998	OBJECTIVE: Recent studies indicate that endothelial type nitric oxide synthase (NOS3) modulates cardiac systolic and diastolic function and the inotropic responsiveness to beta-adrenergic agonists, and may affect myocardial oxygen consumption.	Oxygen	224-230	nitric oxide synthase 3	Rattus norvegicus	80-84
9692515-5	1998	There was evidence of an increase in mPAP, MDA, PAF and ET-1 in the plasma, and activity of PLA2, PAF and ET-1 of the lung tissues when the rats inhaled a 10% mixture of oxygen in nitrogen.	Oxygen	170-176	PCNA clamp associated factor	Rattus norvegicus	48-51
10592513-7	2000	There was little difference in the in vitro and in vivo activities, and glycosylation between Epo produced by the cells cultured in 21% and 2% oxygen.	Oxygen	143-149	erythropoietin	Cricetulus griseus	94-97
10592513-8	2000	Furthermore, forced expression of hypoxia-inducible factor-1alpha (HIF-1alpha) enhanced Epo production in all oxygen concentrations.	Oxygen	110-116	erythropoietin	Cricetulus griseus	88-91
10625631-8	2000	This system and the increases of thylakoid Ndh complex and peroxidase activities under photooxidative stress suggest that the chlororespiratory process consists of the sequence of reactions catalyzed by Ndh complex, peroxidase (acting on reduced plastoquinone), superoxide dismutase, and the non-enzymic one-electron transfer from reduced iron-sulfur protein (FeSP) to O(2).	Oxygen	369-373	prx7	Hordeum vulgare	59-69
10625631-8	2000	This system and the increases of thylakoid Ndh complex and peroxidase activities under photooxidative stress suggest that the chlororespiratory process consists of the sequence of reactions catalyzed by Ndh complex, peroxidase (acting on reduced plastoquinone), superoxide dismutase, and the non-enzymic one-electron transfer from reduced iron-sulfur protein (FeSP) to O(2).	Oxygen	369-373	prx7	Hordeum vulgare	216-226
10678762-5	2000	Their presence has profound implications on the interpretation of spectrophotometric recordings aimed to elucidate the mechanisms of oxygen sensing since their high cytochrome b558 content will obscure possible contributions of cell types involved in the oxygen sensor process.	Oxygen	133-139	cytochrome b, mitochondrial	Rattus norvegicus	165-177
10678762-5	2000	Their presence has profound implications on the interpretation of spectrophotometric recordings aimed to elucidate the mechanisms of oxygen sensing since their high cytochrome b558 content will obscure possible contributions of cell types involved in the oxygen sensor process.	Oxygen	255-261	cytochrome b, mitochondrial	Rattus norvegicus	165-177
11310984-1	2000	It is suggested that the fibrillar amyloid beta peptide (A beta) in brain plays a direct role in neurodegeneration in Alzheimer"s disease, probably through activation of reactive oxygen species formation.	Oxygen	179-185	amyloid beta precursor protein	Rattus norvegicus	57-63
10908461-10	2000	MAIN RESULTS: Nasal CPAP, when applied to preterm infants being extubated following IPPV, reduces the incidence of adverse clinical events (apnea, respiratory acidosis and increased oxygen requirements) indicating the need for additional ventilatory support [RR 0.62 (0.49, 0.79), RD -0.175 (-0.	Oxygen	182-188	centromere protein J	Homo sapiens	20-24
9692515-5	1998	There was evidence of an increase in mPAP, MDA, PAF and ET-1 in the plasma, and activity of PLA2, PAF and ET-1 of the lung tissues when the rats inhaled a 10% mixture of oxygen in nitrogen.	Oxygen	170-176	PCNA clamp associated factor	Rattus norvegicus	98-101
9560314-2	1998	We re-evaluated the reported role of reactive oxygen metabolites (ROMs) in signalling upregulation of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by tumour necrosis factor alpha (TNF-alpha) in vitro.	Oxygen	46-52	intercellular adhesion molecule 1	Homo sapiens	102-135
9560314-2	1998	We re-evaluated the reported role of reactive oxygen metabolites (ROMs) in signalling upregulation of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by tumour necrosis factor alpha (TNF-alpha) in vitro.	Oxygen	46-52	intercellular adhesion molecule 1	Homo sapiens	137-143
2557550-2	1989	The present study is designed to determine if oxygen-centered species generated by the cell-free enzyme-substrate combination of hypoxanthine and xanthine oxidase can induce similar lesions and to identify the specific mediator(s).	Oxygen	46-52	xanthine dehydrogenase	Mus musculus	146-162
9576762-0	1998	Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.	Oxygen	77-83	interleukin 11	Mus musculus	28-42
9576762-3	1998	IL-11 markedly enhanced survival in 100% O2 with 100% of transgene (-) animals dying within 72-96 h and &gt; 90% of transgene (+) animals surviving for more than 10 d. This protection was associated with markedly diminished alveolar-capillary protein leak, endothelial and epithelial membrane injury, lipid peroxidation, and pulmonary neutrophil recruitment.	Oxygen	41-43	interleukin 11	Mus musculus	0-5
9575899-8	1998	Hb-P35 (2%) doubled O2 delivery and lowered glucose and phosphate excretion to the level obtained with 1% Hb-P11.	Oxygen	20-22	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	3-6
10796307-9	2000	MAIN RESULTS: Nasal CPAP, when applied to preterm infants being extubated following IPPV, reduces the incidence of adverse clinical events (apnea, respiratory acidosis and increased oxygen requirements) indicating the need for additional ventilatory support.	Oxygen	182-188	centromere protein J	Homo sapiens	20-24
10796307-11	2000	REVIEWER"S CONCLUSIONS:  IMPLICATIONS FOR PRACTICE: nasal CPAP is effective in preventing failure of extubation and reducing oxygen use at 28 days of life in preterm infants following a period of endotracheal intubation and IPPV.	Oxygen	125-131	centromere protein J	Homo sapiens	58-62
10682722-8	2000	These data emphasize the participation of caspase-1 in neuronal injury consecutive to oxygen deprivation, and provide new insight into the possible cellular mechanisms by which caspase inhibitors may protect developing brain neurons.	Oxygen	86-92	caspase 1	Rattus norvegicus	42-51
10682722-8	2000	These data emphasize the participation of caspase-1 in neuronal injury consecutive to oxygen deprivation, and provide new insight into the possible cellular mechanisms by which caspase inhibitors may protect developing brain neurons.	Oxygen	86-92	caspase 1	Rattus norvegicus	42-49
9555909-0	1998	Oxygen regulation of the ccoN gene encoding a component of the cbb3 oxidase in Rhodobacter sphaeroides 2.4.1T: involvement of the FnrL protein.	Oxygen	0-6	cytochrome-c oxidase, cbb3-type subunit I	Rhodobacter sphaeroides 2.4.1	25-29
2812898-4	1989	The insulin-infused fetal sheep had higher mean +/- SD plasma insulin concentrations (448 +/- 507 versus 11 +/- 8 mU/L; p less than 0.001) and lower arterial oxygen saturations (38 +/- 7 versus 54 +/- 9%; p less than 0.02).	Oxygen	158-164	LOC105613195	Ovis aries	4-11
9555909-0	1998	Oxygen regulation of the ccoN gene encoding a component of the cbb3 oxidase in Rhodobacter sphaeroides 2.4.1T: involvement of the FnrL protein.	Oxygen	0-6	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	130-134
9555909-2	1998	The beta-galactosidase activity of a ccoN::lacZ transcriptional fusion was low under high (30%)-oxygen and anaerobic growth conditions.	Oxygen	96-102	cytochrome-c oxidase, cbb3-type subunit I	Rhodobacter sphaeroides 2.4.1	37-41
9555909-3	1998	Maximal ccoN::lacZ expression was observed when the oxygen concentration was lowered to 2%.	Oxygen	52-58	cytochrome-c oxidase, cbb3-type subunit I	Rhodobacter sphaeroides 2.4.1	8-12
10594641-6	1999	Because hypoxia induces HIF-1 in other tissues, systemic hypoxia (6% O2 for 4.5 h) was also shown to increase HIF-1alpha protein expression in the adult rat brain.	Oxygen	69-71	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	110-120
2679260-4	1989	The present study was undertaken to determine whether continuous exposure to 100% oxygen during the period of alveolar development in the rat (Days 4 to 13) would alter lung elastin.	Oxygen	82-88	elastin	Rattus norvegicus	174-181
10624756-6	1999	Inhaled NO and almitrine bismesylate increased arterial oxygen tension (Pa,O2)/inspiratory oxygen fraction (FI,O2) (p&lt;0.001).	Oxygen	91-97	immunoglobulin kappa variable 1D-39	Homo sapiens	108-113
10506583-3	1999	To explain how induction of HO-1 results in protection against oxygen toxicity, hamster fibroblasts (HA-1) were stably transfected with a tetracycline response plasmid containing the full-length rat HO-1 cDNA construct to allow for regulation of gene expression by varying concentrations of doxycycline (Dox).	Oxygen	63-69	heme oxygenase 1	Rattus norvegicus	28-32
10487921-2	1999	ATF1 transcription is negatively regulated by unsaturated fatty acids and oxygen.	Oxygen	74-80	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
10484464-2	1999	Abnormal O2 tensions may alter repair of damaged elastin fibers.	Oxygen	9-11	elastin	Rattus norvegicus	49-56
10484464-8	1999	When returned to 21% O2, tropoelastin mRNA recovered to control levels in part by upregulating tropoelastin gene transcription.	Oxygen	21-23	elastin	Rattus norvegicus	25-37
10395749-6	1999	Exposure to HOCl can cause lethal DNA damage as judged by the fact that recA sensitivity to HOCl was oxygen dependent.	Oxygen	101-107	RAD51 recombinase	Homo sapiens	72-76
10552564-0	1999	Headspace oxygen in sample vials affects volatiles production of meat during the automated purge-and-Trap/GC analyses.	Oxygen	10-16	TRAP	Homo sapiens	101-105
10552564-1	1999	Headspace oxygen in sample vial for the purge-and-trap dynamic headspace/gas chromatography method oxidizes meat if held hours before purging, influences volatile profiles, and misrepresents the true composition of volatiles.	Oxygen	10-16	TRAP	Homo sapiens	50-54
10348862-0	1999	Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress.	Oxygen	79-85	inner membrane mitochondrial protein	Homo sapiens	14-17
10348862-2	1999	Northern blotting analysis demonstrated that hmp transcription increased when a microaerophilic culture became oxygen limited as it entered stationary phase at 20 days.	Oxygen	111-117	inner membrane mitochondrial protein	Homo sapiens	45-48
10348862-7	1999	These data indicate that oxygen limitation is the trigger for hmp gene transcription.	Oxygen	25-31	inner membrane mitochondrial protein	Homo sapiens	62-65
10348862-12	1999	These observations of hmp mRNA induction in response to O2 limitation and nitrosative stress suggest that the hmp gene of M. tuberculosis may have a role in protection of the organism from NO killing under microaerophilic conditions.	Oxygen	56-58	inner membrane mitochondrial protein	Homo sapiens	22-25
10348862-12	1999	These observations of hmp mRNA induction in response to O2 limitation and nitrosative stress suggest that the hmp gene of M. tuberculosis may have a role in protection of the organism from NO killing under microaerophilic conditions.	Oxygen	56-58	inner membrane mitochondrial protein	Homo sapiens	110-113
10215594-1	1999	The glucagon-stimulated transcription of the cytosolic phosphoenolpyruvate carboxykinase-1 (PCK1) gene is mediated by cAMP and positively modulated by oxygen in primary hepatocytes.	Oxygen	151-157	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	92-96
10215594-12	1999	These findings corroborated that sequences of the putative CRE2 site were responsible for the modulation by oxygen of the CRE1-dependent induction by glucagon of PCK1 gene transcription.	Oxygen	108-114	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	162-166
10400168-2	1999	These variables are known to affect oxygen saturation readings measured by the OSM3 Hemoximeter.	Oxygen	36-42	kinesin family member 17	Homo sapiens	79-83
10201680-11	1999	CPAP also increased arteriovenous oxygen content difference (10.7+/-3.1 vs. 5.5+/-2.3 ml/dl blood) and CO2 elimination (120+/-20 vs. 12+/-20 ml/min; P &lt; 0.01).	Oxygen	34-40	centromere protein J	Homo sapiens	0-4
10200221-10	1999	Moreover, neurons of ages P14 or P21 showed a partial or complete recovery after reintroduction of oxygen and glucose, unlike mature neurons.	Oxygen	99-105	KRAS proto-oncogene, GTPase	Rattus norvegicus	33-36
10212003-6	1999	Second, Northern blot analysis revealed that pericyte levels of mRNA encoding VEGF increased as the atmospheric oxygen tension was decreased; this was accompanied by an increase in de novo synthesis of VEGF proteins.	Oxygen	112-118	vascular endothelial growth factor A	Bos taurus	78-82
10385035-0	1999	K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues.	Oxygen	53-59	carbonic anhydrase 2	Homo sapiens	0-10
10385035-2	1999	We review here the modifications of K+ and Ca2+ channel activity and the resulting changes in cytosolic [Ca2+] induced by low P(O2) in glomus cells and arterial smooth muscle which are well known examples of O2-sensitive cells.	Oxygen	128-130	carbonic anhydrase 2	Homo sapiens	36-46
10385035-2	1999	We review here the modifications of K+ and Ca2+ channel activity and the resulting changes in cytosolic [Ca2+] induced by low P(O2) in glomus cells and arterial smooth muscle which are well known examples of O2-sensitive cells.	Oxygen	208-210	carbonic anhydrase 2	Homo sapiens	36-46
10097094-5	1999	Interactions with dissolved oxygen and with deoxyhemoglobin are found to contribute to the spin-lattice relaxation time of 129Xe in blood, the latter interaction having greater effect.	Oxygen	28-34	spindlin 1	Homo sapiens	91-95
10052939-2	1999	To gain further insight into the role of the cbb3 oxidase and the cognate ccoNOQP operon in the oxygen regulation of PS gene expression, we constructed nonpolar, in-frame deletions within the ccoN and ccoQ genes.	Oxygen	96-102	cytochrome-c oxidase, cbb3-type subunit I	Rhodobacter sphaeroides 2.4.1	74-78
10052939-3	1999	Whereas mutations in ccoN, ccoQ, and ccoP resulted in PS gene expression in the presence of oxygen, only the ccoQ mutation showed both the normal flow of reductant through the cbb3 oxidase and the absence of any alteration in the relative levels of spheroidene and spheroidenone, as is observed for those mutations in the cco operon that result in the loss of terminal oxidase activity.	Oxygen	92-98	cytochrome-c oxidase, cbb3-type subunit I	Rhodobacter sphaeroides 2.4.1	21-25
10070108-0	1999	Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells.	Oxygen	73-79	heme oxygenase 1	Rattus norvegicus	32-36
9950880-2	1999	Because hemoglobin-based oxygen carriers (HBOC) have been demonstrated to cause vasoconstriction and thereby increase arterial pressure by interacting with endothelium-derived factors such as nitric oxide and endothelin-1, we hypothesized that hemoglobin could penetrate into the endothelial cells.	Oxygen	25-31	endothelin-1	Cavia porcellus	209-221
10092884-10	1999	SSAT is also induced by low oxygen tension which mimics perivenous conditions.	Oxygen	28-34	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-4
9882531-10	1999	mRNA expression of cytoprotective enzymes responded to the pericellular availability of oxygen and was most pronounced in the case of MnSOD.	Oxygen	88-94	superoxide dismutase 2	Rattus norvegicus	134-139
9831730-3	1999	To this end microvascular PO2 (microPO2) was measured by quenching of Pd-porphyrin phosphorescence by oxygen and validated for the intestines.	Oxygen	102-108	PO2	Sus scrofa	26-29
10619365-2	1999	The therapeutic effect of VEGF-neutralizing antibody on oxygen-induced retinopathy in an experimental murine model of proliferative retinopathy was investigated.	Oxygen	56-62	vascular endothelial growth factor A	Mus musculus	26-30
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	46-48	H4 clustered histone 4	Homo sapiens	117-120
9623258-7	1998	CONCLUSIONS: Inhalation of 92% O2 and 8% CO2 is a possibility for decreasing the peripheral resistance of OA and CRA.	Oxygen	31-33	myotubularin related protein 11	Homo sapiens	113-116
9530165-1	1998	Manganese superoxide dismutase (MnSOD) activity falls approximately 50% in lung during 48 h of exposure of adult rats to &gt; 95% O2 (L. B. Clerch and D. Massaro.	Oxygen	130-132	superoxide dismutase 2	Rattus norvegicus	0-30
9530165-1	1998	Manganese superoxide dismutase (MnSOD) activity falls approximately 50% in lung during 48 h of exposure of adult rats to &gt; 95% O2 (L. B. Clerch and D. Massaro.	Oxygen	130-132	superoxide dismutase 2	Rattus norvegicus	32-37
9530165-6	1998	In rats, a decrease in lung MnSOD activity during an initial 48 h of exposure to &gt; 95% O2 and its increase during an immediately subsequent 24 h in air were due to decreases and increases, respectively, in MnSOD specific activity and synthesis rate; the latter was due to altered translational efficiency.	Oxygen	90-92	superoxide dismutase 2	Rattus norvegicus	28-33
9530165-6	1998	In rats, a decrease in lung MnSOD activity during an initial 48 h of exposure to &gt; 95% O2 and its increase during an immediately subsequent 24 h in air were due to decreases and increases, respectively, in MnSOD specific activity and synthesis rate; the latter was due to altered translational efficiency.	Oxygen	90-92	superoxide dismutase 2	Rattus norvegicus	209-214
9530245-5	1998	4) Expression of the L-arginine transporter mCAT-2 is increased greater than twofold by reduced O2 culture.	Oxygen	96-98	dominant cataract 2	Mus musculus	44-50
9540806-4	1998	Photo-oxidation by UVB-light and O2 reverses the inhibition of tyrosinase by 6-BH4 and 7-BH4 with the 6-BH4/tyrosinase complex being four-fold more photolabile than 7-BH4/tyrosinase.	Oxygen	33-35	tyrosinase	Homo sapiens	63-73
9540806-4	1998	Photo-oxidation by UVB-light and O2 reverses the inhibition of tyrosinase by 6-BH4 and 7-BH4 with the 6-BH4/tyrosinase complex being four-fold more photolabile than 7-BH4/tyrosinase.	Oxygen	33-35	tyrosinase	Homo sapiens	102-118
9540806-4	1998	Photo-oxidation by UVB-light and O2 reverses the inhibition of tyrosinase by 6-BH4 and 7-BH4 with the 6-BH4/tyrosinase complex being four-fold more photolabile than 7-BH4/tyrosinase.	Oxygen	33-35	tyrosinase	Homo sapiens	165-181
9504421-2	1998	The addition of PAF (20 nM) to the perfusate increased glucose production concomitant with suppression of oxygen consumption in control rats without endotoxin treatment.	Oxygen	106-112	PCNA clamp associated factor	Rattus norvegicus	16-19
9504421-3	1998	At 6 h after endotoxin administration, PAF caused severe suppression of oxygen consumption, but glucose production was greatly inhibited.	Oxygen	72-78	PCNA clamp associated factor	Rattus norvegicus	39-42
9504421-4	1998	At 24 h after endotoxin treatment, PAF caused less suppression of oxygen consumption than the control, and glucose production was partially restored.	Oxygen	66-72	PCNA clamp associated factor	Rattus norvegicus	35-38
9460794-11	1998	In vitro TGF-beta protects neurons from damage induced by treatment with beta-amyloid peptide, FeSO4 (induces production of reactive oxygen species), Ca2+ ionophores, glutamate, glutamate receptor agonists and MPTP (toxic for dopaminergic neurons).	Oxygen	133-139	transforming growth factor alpha	Gallus gallus	9-17
9453434-10	1997	This suggests that even transient nonlethal hypoxia affects the epidermal growth factor-induced DNA synthesis of rat hepatocytes through reversible changes in the epidermal growth factor receptor molecule, which depends on oxygen availability.	Oxygen	223-229	epidermal growth factor receptor	Rattus norvegicus	163-195
9335571-5	1997	Results from stopped-flow studies indicate that the hydroperoxide level influences the rate of Compound II formation indirectly, via changes in the transient accumulation of Compound I, rather than by reducing Compound I. PGHS and soybean lipoxygenase reactions with 11,14-eicosadienoic acid (20:2) were also analyzed using a spectrophotometer cuvette fitted with an oxygen electrode to monitor lipid product formation and oxygen consumption simultaneously.	Oxygen	367-373	linoleate 9S-lipoxygenase-4	Glycine max	239-251
9335571-6	1997	The results show that the oxygen electrode signal is inherently dampened and thus underestimates the oxygen consumption rate; the discrepancy is much larger for the more rapidly accelerating PGHS reaction than for the lipoxygenase reaction.	Oxygen	26-32	linoleate 9S-lipoxygenase-4	Glycine max	218-230
9335571-6	1997	The results show that the oxygen electrode signal is inherently dampened and thus underestimates the oxygen consumption rate; the discrepancy is much larger for the more rapidly accelerating PGHS reaction than for the lipoxygenase reaction.	Oxygen	101-107	linoleate 9S-lipoxygenase-4	Glycine max	218-230
9335571-7	1997	When correction is made for the electrode dampening, the ratio between the peak rates of oxygen consumption and lipid product formation was near unity for both PGHS and lipoxygenase, indicating a reaction stoichiometry of about 1 mol of O2 consumed/mol of 20:2 oxygenated for both enzymes.	Oxygen	89-95	linoleate 9S-lipoxygenase-4	Glycine max	160-181
9335571-7	1997	When correction is made for the electrode dampening, the ratio between the peak rates of oxygen consumption and lipid product formation was near unity for both PGHS and lipoxygenase, indicating a reaction stoichiometry of about 1 mol of O2 consumed/mol of 20:2 oxygenated for both enzymes.	Oxygen	237-239	linoleate 9S-lipoxygenase-4	Glycine max	160-181
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	KIT ligand	Homo sapiens	204-220
9328456-1	1997	Incubation in severe hypoxia (1% oxygen) increased the number of erythroid bursts generated from full-term CD34+, or premature mononucleated, human cord blood (CB) cells, in semisolid cultures containing stem cell factor (SCF), interleukin (IL)-3 and erythropoietin (EPO).	Oxygen	33-39	KIT ligand	Homo sapiens	222-225
9278404-3	1997	Most differences between XO and XDH are localized to the FAD center, the site at which the oxidizing substrates NAD and molecular oxygen react.	Oxygen	130-136	xanthine dehydrogenase	Bos taurus	32-35
9312549-4	1997	Molecular oxygen is required for enzymatic activity, and cyanide, divalent copper, as well as antibodies raised against cytochrome b5 are inhibitory, which suggests that this enzyme should be named dihydroceramide desaturase based on these similarities with the mechanism of delta9-desaturase (stearoyl-CoA desaturase).	Oxygen	10-16	stearoyl-CoA desaturase	Rattus norvegicus	294-317
9332317-8	1997	This may indicate that increased production of O2 by neutrophils in which the Bcr gene is not expressed requires either that gene expression is absent in the earlier stages of myeloid differentiation/maturation, so that when inhibition occurs in the terminally differentiated neutrophils their functional status is no longer influenced, or that the residual low-level expression of the gene which may be present in the antisense-treated cells is sufficient to provide a normal response to stimulation.	Oxygen	47-49	BCR activator of RhoGEF and GTPase	Homo sapiens	78-81
18259411-2	1997	The HO2 is formed by the 355-nm photolysis of Cl2 in the presence of CH3 OH and O2 and monitored by a phase-sensitive detection of the second-harmonic (2f ) signal in the 2?1 band with a 1.5- ?m diode laser directly modulated at 5 MHz.	Oxygen	5-7	endogenous retrovirus group W member 5	Homo sapiens	46-49
9313864-7	1997	An examination of the SAR of these analogues shows that translocating the napthyl group in AAIs from the C-3 position to C-4 via an oxygen (ether linkage) decreases activity which is in contrast to previous findings that a naphthylcarbonyl at C-4 retains activity.	Oxygen	132-138	complement C3	Homo sapiens	105-108
9441906-7	1997	The oxygen uptake observed during oxidation of GSH by peroxynitrite salt was inhibited by spin traps.	Oxygen	4-10	spindlin 1	Homo sapiens	90-94
9288847-7	1997	The rates of synthesis of oxygen-regulated proteins (GRP78, GRP94, HSP70 and HSP90) were transiently perturbed to a similar extent in all lines after hypoxia treatment.	Oxygen	26-32	heat shock protein 90 beta family member 1	Homo sapiens	60-65
9288847-7	1997	The rates of synthesis of oxygen-regulated proteins (GRP78, GRP94, HSP70 and HSP90) were transiently perturbed to a similar extent in all lines after hypoxia treatment.	Oxygen	26-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	67-72
18966880-1	1997	Electropolymerizations of aniline and pyrrole solutions containing uricase at a neutral pH was performed to immobilize the enzyme on the surface of the gas diffusion carbon felt, and a selective uric acid sensor was fabricated by combining immobilized enzyme carbon felt and an oxygen electrode with oxygen gas permeable membrane.	Oxygen	278-284	urate oxidase (pseudogene)	Homo sapiens	67-74
18966880-1	1997	Electropolymerizations of aniline and pyrrole solutions containing uricase at a neutral pH was performed to immobilize the enzyme on the surface of the gas diffusion carbon felt, and a selective uric acid sensor was fabricated by combining immobilized enzyme carbon felt and an oxygen electrode with oxygen gas permeable membrane.	Oxygen	300-306	urate oxidase (pseudogene)	Homo sapiens	67-74
18966880-2	1997	This carbon felt has a desirable feature for uricase sensing because an extremely efficient supply of oxygen for the enzymatic reaction can be realized due to its porosity permitting a transfer of oxygen.	Oxygen	102-108	urate oxidase (pseudogene)	Homo sapiens	45-52
18966880-2	1997	This carbon felt has a desirable feature for uricase sensing because an extremely efficient supply of oxygen for the enzymatic reaction can be realized due to its porosity permitting a transfer of oxygen.	Oxygen	197-203	urate oxidase (pseudogene)	Homo sapiens	45-52
9193882-7	1997	Activity was measured by following DAK-dependent oxygen uptake polarographically at 37 degrees C in pyrophosphate buffer (pH 8.8) containing the glucose-6-phosphate NADPH-generating system.	Oxygen	49-55	triokinase and FMN cyclase	Rattus norvegicus	35-38
9173956-8	1997	O2 deficit decreased between WT1 and WT2 in H only (P &lt; 0.01).	Oxygen	0-2	multiple tumor-associated chromosome region 1	Homo sapiens	37-40
9230628-1	1997	Dissociation curves for oxygen of dilute samples of human adult Hb-A were evaluated on this occasion, by using the Oximeter-539 WTW with its sensor, and a suitable spectrophotometer.	Oxygen	24-30	keratin 90, pseudogene	Homo sapiens	64-68
9930594-2	1998	Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils.	Oxygen	65-71	C-C motif chemokine ligand 5	Homo sapiens	47-53
9930594-8	1998	CONCLUSIONS: Thus, we concluded that RANTES may play an important role in the pathogenesis of allergic inflammation through its involvement in eosinophil activation, as evidenced by oxygen products, as well as in selective eosinophil infiltration as selective eosinophil chemoattractant.	Oxygen	182-188	C-C motif chemokine ligand 5	Homo sapiens	37-43
9874192-9	1998	Finally, the study of the metabolic adaptation of glucose metabolism to oxygen deprivation revealed the implication of nitric oxide and cyclic GMP in the control of heart glucose metabolism.	Oxygen	72-78	5'-nucleotidase, cytosolic II	Homo sapiens	143-146
9808778-9	1998	Based on these results, we propose that the high production of AM may be the mechanism by which the embryos survive at the early postimplantation period by pooling maternal blood in the implantation site in order to secure nutrition and oxygen before the establishment of efficient embryo-maternal circulation through the mature placenta.	Oxygen	237-243	adrenomedullin	Mus musculus	63-65
9823936-6	1998	Mesenteric venous PO2 was increased after resuscitation with lactated Ringer"s solution and modified gelatin but not with DCLHb, which was associated with an increased gut oxygen consumption in the latter group.	Oxygen	172-178	PO2	Sus scrofa	18-21
9789011-6	1998	Exposure of flies to 100% oxygen resulted in an increase in the level of ANT carbonyl content and a loss in its activity.	Oxygen	26-32	stress-sensitive B	Drosophila melanogaster	73-76
9761743-0	1998	Involvement of a local fenton reaction in the reciprocal modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes.	Oxygen	71-73	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	118-151
9761743-1	1998	H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene.	Oxygen	2-4	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	111-144
9761743-1	1998	H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene.	Oxygen	2-4	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	146-149
9761743-13	1998	Thus a local Fenton reaction is involved in the O2 signalling, which modulated the glucagon- and insulin-dependent PCK gene and GK gene activation.	Oxygen	48-50	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	115-118
9799656-0	1998	Insulin improves cardiac contractile function and oxygen utilization efficiency during moderate ischemia without compromising myocardial energetics.	Oxygen	50-56	insulin	Canis lupus familiaris	0-7
2696512-3	1989	Constitutive but low levels of PDGF-B mRNA (4.0 kb) were observed in the lungs of control animals exposed to 21% oxygen.	Oxygen	113-119	platelet derived growth factor subunit B	Rattus norvegicus	31-37
9748311-3	1998	Agents which favor a closed pore, such as cyclosporin A, ADP, Mg2+, or bovine serum albumin, do not close the H+-conducting substate, but it closes spontaneously when respiration becomes limited by the availability of O2.	Oxygen	218-220	albumin	Rattus norvegicus	78-91
2776842-2	1989	The intracoronary administration of 0.7-23.5 nmol NPY to hearts during beta adrenergic blockade produced a dose-dependent increase in coronary vascular resistance ranging from 0.10 to 0.49 mmHg.min-1.ml-1.100 g-1 without changes in myocardial oxygen consumption.	Oxygen	243-249	neuropeptide Y	Canis lupus familiaris	50-53
9769507-7	1998	In blood, oxidation state of hemoglobin results from very complex phenomena and if the body struggles against methemoglobin formation to maintain oxygen transport, the oxidation of hemoglobin is sometimes useful to protect tissues against various and numerous endogenous radical or non-radical oxidizing agents.	Oxygen	146-152	hemoglobin subunit gamma 2	Homo sapiens	110-123
2526588-12	1989	Phentolamine (1.3 microM) and propranolol (0.1 microM) each reduced peak hypoxia-induced (0% O2) ANF release to 333 and 310%, respectively, whereas atropine sulfate (15 microM) had no inhibitory effect.	Oxygen	93-95	natriuretic peptide A	Rattus norvegicus	97-100
9737429-3	1998	MnSOD is an antioxidant enzyme that protects mitochondria from oxygen radical damage.	Oxygen	63-69	superoxide dismutase 2	Rattus norvegicus	0-5
2502778-1	1989	Soybean lipoxygenase shows a secondary peroxidase/oxidase activity: The aerobic reaction with isobutanal, enhanced by hydrogen peroxide as a cosubstrate, yields acetone, exhibits chemiluminescence and consumes oxygen (phi cl = 1.3 x 10(-9) photons/O2 molecule consumed).	Oxygen	248-250	linoleate 9S-lipoxygenase-4	Glycine max	8-20
9705865-0	1998	Regulation of ferritin synthesis and iron regulatory protein 1 by oxygen in mouse peritoneal macrophages.	Oxygen	66-72	aconitase 1	Mus musculus	37-62
9705865-2	1998	In this study, we have shown that in mouse peritoneal macrophages, the synthesis of ferritin was enhanced and the IRE binding activity of IRP-1 was diminished when the oxygen tension was decreased.	Oxygen	168-174	aconitase 1	Mus musculus	138-143
9705865-5	1998	The decreased activity of IRP-1 under hypoxia was reversed by adding O2(-)-generating agents.	Oxygen	69-74	aconitase 1	Mus musculus	26-31
9705865-6	1998	These data suggest that O2- generated in the cell is involved in alterations of ferritin synthesis and the activity of IRP-1 by oxygen.	Oxygen	24-26	aconitase 1	Mus musculus	119-124
9705865-6	1998	These data suggest that O2- generated in the cell is involved in alterations of ferritin synthesis and the activity of IRP-1 by oxygen.	Oxygen	128-134	aconitase 1	Mus musculus	119-124
2495799-5	1989	The dihydric phenol product which results is capable of met-tyrosinase recruitment by electron donation to the cupric active site generating the cuprous form of the enzyme which binds oxygen and is able to oxidise monohydric phenols.	Oxygen	184-190	tyrosinase	Homo sapiens	60-70
9691095-5	1998	Urine BLP levels increased soon after birth only in 100% O2-treated 140-d animals which developed BPD, correlating closely with severity of subsequent chronic lung disease.	Oxygen	57-59	dynein light chain roadblock-type 1	Homo sapiens	6-9
11670492-3	1998	The phosphane 1 has a pseudo trigonal bipyramidal (TBP) structure due to coordination of a carbonyl oxygen atom at an axial site.	Oxygen	100-106	TATA-box binding protein	Homo sapiens	51-54
9671710-11	1998	This enzyme could be converted to an oxygen-insensitive species by addition of NADPH, indicating that bound pyridine nucleotide is important for enzyme stability.	Oxygen	37-43	2,4-dienoyl-CoA reductase 1	Homo sapiens	79-84
9708893-2	1998	In recent literature on the mechanism of action of hammerhead ribozymes, one important role of divalent metal ions is generally suggested to be an electrophilic catalyst by directly coordinating with the pro-Rp oxygen of the scissile phosphate to stabilize the transition state.	Oxygen	211-217	protein only RNase P catalytic subunit	Homo sapiens	204-210
9708893-4	1998	Reexamination of thio effects with substrates having a GUA triplet at the cleavage site shows that, in agreement with the previous finding, the cleavage rate, in the presence of Mg2+ ions, is significantly reduced in the case of the phosphorothioate substrate (RpS), wherein the pro-Rp oxygen at the scissile phosphate is replaced by sulfur, while the cleavage rate is reduced to a much lesser extent for the other isomer (SpS), wherein the pro-Sp oxygen at the scissile phosphate is replaced by sulfur.	Oxygen	286-292	protein only RNase P catalytic subunit	Homo sapiens	279-285
9675816-2	1998	ATF1 expression is repressed by unsaturated fatty acids or oxygen.	Oxygen	59-65	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
9675816-10	1998	However, the ATF1 transcript in this double gene disruptant was repressed by oxygen.	Oxygen	77-83	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	13-17
9675816-11	1998	These results suggested that ATF1 transcription was co-regulated by the same mechanism as the OLE1 gene and that unsaturated fatty acids and oxygen repressed the ATF1 transcript by a different regulation pathway.	Oxygen	141-147	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	94-98
9675816-11	1998	These results suggested that ATF1 transcription was co-regulated by the same mechanism as the OLE1 gene and that unsaturated fatty acids and oxygen repressed the ATF1 transcript by a different regulation pathway.	Oxygen	141-147	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	162-166
9698817-7	1998	The alternative oxidase activity is dependent on substrate availability: total ubiquinone concentration and its redox state in the membrane and O2 concentration in the cell.	Oxygen	144-146	acyl-CoA oxidase 1	Homo sapiens	4-23
9665595-2	1998	Mitochondrial function was reported to be affected following A beta exposure, as demonstrated by depolarization of the mitochondrial membrane, decrease of oxygen consumption and by the inhibition of complexes I, III and IV of the mitochondrial respiratory chain.	Oxygen	155-161	amyloid beta precursor protein	Rattus norvegicus	61-67
9618303-0	1998	Involvement of reactive oxygen intermediates in lectin-induced protein-tyrosine phosphorylation of Syk in THP-1 cells.	Oxygen	24-30	spleen associated tyrosine kinase	Homo sapiens	99-102
9582295-17	1998	Subsequent deprotonation and reaction of the intermediate alpha-amino alkyl radicals with molecular oxygen leads to the formation of O-2, from which H2O2 is produced by dismutation.	Oxygen	100-106	immunoglobulin kappa variable 1D-39	Homo sapiens	133-136
9612286-7	1998	The oxygen-induced DNA strand breaks were blocked by the addition of 20 ng/ml of keratinocyte growth factor (KGF) to the culture medium from the time of plating and were partly inhibited by Matrigel or a soluble extract of Matrigel.	Oxygen	4-10	fibroblast growth factor 7	Rattus norvegicus	81-107
9612286-7	1998	The oxygen-induced DNA strand breaks were blocked by the addition of 20 ng/ml of keratinocyte growth factor (KGF) to the culture medium from the time of plating and were partly inhibited by Matrigel or a soluble extract of Matrigel.	Oxygen	4-10	fibroblast growth factor 7	Rattus norvegicus	109-112
9612286-9	1998	We conclude that sublethal doses of oxygen in vivo cause damage to AEC2, resulting in apoptosis in ex vivo culture, and that KGF can reduce the oxygen-induced DNA damage.	Oxygen	144-150	fibroblast growth factor 7	Rattus norvegicus	125-128
9585480-8	1998	However, nitrated BPTI subjected to trypsin digestion stimulated reduction of acetylated ferricytochrome c. These results suggest that, as with other nitroaromatic compounds, nitrotyrosine may be enzymatically reduced to the corresponding nitro anion radical (ArNO2*-) which is then oxidized by molecular oxygen to yield O2*- and regenerate ArNO2.	Oxygen	305-311	spleen trypsin inhibitor I	Bos taurus	18-22
9535834-7	1998	These new findings lead us to conclude that the formation of the alpha1beta1 contact produces in the beta chain a conformational constraint whereby the distal histidine at position 63 is tilted away slightly from the bound dioxygen, preventing the proton-catalyzed displacement of O-2 by a solvent water molecule.	Oxygen	223-231	immunoglobulin kappa variable 1D-39	Homo sapiens	281-284
9669840-7	1998	However, ex vivo expansion of the sorted subsets with interleukin 3, stem cell factor and FLT3 ligand for 2 weeks resulted in a significant production of O2- and H2O2/HOCl by CD34+/CD117low cell fraction, compared to the same sorted but not expanded counterparts.	Oxygen	154-156	KIT ligand	Homo sapiens	69-85
9588101-21	1998	In the case of high level of MetHb the drug of choice is administration of hyperbaric oxygen, methylene blue, ascorbic acid intravenously or riboflavin in high doses.	Oxygen	86-92	hemoglobin subunit gamma 2	Homo sapiens	29-34
9530169-6	1998	Transcripts of both the SP-A1 and SP-A2 genes were increased approximately 100% in tissues maintained in 70% O2 compared with control tissues.	Oxygen	109-111	surfactant protein A2	Homo sapiens	34-39
9530169-8	1998	Furthermore, because there is no differential effect of O2 on the expression of SP-A1 vs. SP-A2 mRNA, the properties of these genes that mediate regulation by O2 must be conserved between the two genes.	Oxygen	159-161	surfactant protein A2	Homo sapiens	90-95
10682619-2	1998	TFL (0-217 mg/L) could scavenge O2-.	Oxygen	32-34	zinc finger CCCH type containing 12D	Mus musculus	0-3
9707853-14	1998	CONCLUSION: Early use of postnatal dexamethasone reduces the disease severity and oxygen requirement in RDS and hence would be useful in the Indian context.	Oxygen	82-88	peripherin 2	Homo sapiens	104-107
9564616-5	1998	(b) It accelerates the reactivity of the covalently bound flavin with oxygen, effectively increasing the Vm (particularly for MAO-B).	Oxygen	70-76	monoamine oxidase B	Homo sapiens	126-131
9390187-7	1997	We conclude that control of XO-XDH levels by oxygen tension is a complex process which involves several points of regulation.	Oxygen	45-51	xanthine dehydrogenase	Mus musculus	31-34
9453434-0	1997	Oxygen dependency of epidermal growth factor receptor binding and DNA synthesis of rat hepatocytes.	Oxygen	0-6	epidermal growth factor receptor	Rattus norvegicus	21-53
9426593-0	1997	Differential expression of two tomato lactate dehydrogenase genes in response to oxygen deficit.	Oxygen	81-87	L-lactate dehydrogenase	Solanum lycopersicum	38-59
9426613-6	1997	Ldh1 but not ldh2 is inducible by oxygen deficit in both roots and fruit.	Oxygen	34-40	L-lactate dehydrogenase	Solanum lycopersicum	0-4
9398165-5	1997	The reaction of H2O2 and NHA with nNOS was at least 10-fold slower than the reaction of NADPH, O2, and NHA (Vmax,app = 49 +/- 2 nmol min-1 mg-1 for the reactions with 10 microM added H4B).	Oxygen	18-20	H4 clustered histone 4	Homo sapiens	183-186
9353290-2	1997	An understanding of this reaction is necessary for a complete description of XDH turnover with its presumed natural electron acceptor and to address the preference of XDH for NAD over oxygen as a substrate.	Oxygen	184-190	xanthine dehydrogenase	Bos taurus	77-80
9353290-2	1997	An understanding of this reaction is necessary for a complete description of XDH turnover with its presumed natural electron acceptor and to address the preference of XDH for NAD over oxygen as a substrate.	Oxygen	184-190	xanthine dehydrogenase	Bos taurus	167-170
9353124-7	1997	At submicromolar concentrations, PSDP but not PSMP inhibit O2- production by human neutrophil cell-free oxidase preparations.	Oxygen	59-61	phospholipid phosphatase 6	Homo sapiens	33-37
9475040-12	1997	Thus it is suggested that the deleterious effect of AlP on heart is mediated by both declined cellular metabolism of the myocardium as well as by necrosis of the cardiac tissue resulting in the release of reactive oxygen intermediates.	Oxygen	214-220	PDZ and LIM domain 3	Rattus norvegicus	52-55
9256509-1	1997	We previously demonstrated that alpha1B-adrenergic receptor (AR) gene transcription, mRNA, and functionally coupled receptors increase during 3% O2 exposure in aorta, but not in vena cava smooth muscle cells (SMC).	Oxygen	145-147	adrenoceptor alpha 1B	Homo sapiens	32-59
9256509-1	1997	We previously demonstrated that alpha1B-adrenergic receptor (AR) gene transcription, mRNA, and functionally coupled receptors increase during 3% O2 exposure in aorta, but not in vena cava smooth muscle cells (SMC).	Oxygen	145-147	adrenoceptor alpha 1B	Homo sapiens	61-63
9242677-0	1997	Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.	Oxygen	0-6	transferrin	Mus musculus	17-28
9306709-11	1997	We examined the effect of recombinant soluble ICAM-1 and its ligands on eosinophil-induced radical oxygen products.	Oxygen	99-105	intercellular adhesion molecule 1	Homo sapiens	46-52
11671726-3	1997	Interestingly, syn stereoselectivity is eroded and reactions proceed more rapidly when the steric bulk of the oxygen substituent is reduced as in the hydroxy and methoxy derivatives.	Oxygen	110-116	synemin	Homo sapiens	15-18
9144197-2	1997	Functionally, it was able to substitute for TspO by negatively regulating the expression of photosynthesis genes in response to oxygen.	Oxygen	128-134	translocator protein	Homo sapiens	44-48
9160836-8	1997	In addition, alveolar macrophages express IGF-I and type II epithelial cells express IGF-II in control and oxygen-injured lung.	Oxygen	107-113	insulin-like growth factor 2	Rattus norvegicus	85-91
9168606-0	1997	Escherichia coli flavohaemoglobin (Hmp) reduces cytochrome c and Fe(III)-hydroxamate K by electron transfer from NADH via FAD: sensitivity of oxidoreductase activity to haem-bound dioxygen.	Oxygen	180-188	oxidoreductase	Escherichia coli	142-156
9168606-5	1997	The NADH-cytochrome c oxidoreductase activity of Hmp was slightly sensitive to the binding and reduction of O2 at the haem.	Oxygen	108-110	oxidoreductase	Escherichia coli	22-36
9110920-5	1997	Exposure to 95% O2 activated resting AM to produce significantly increased amounts of IL-1beta and IL-6.	Oxygen	16-18	interleukin-1 beta	Macaca fascicularis	86-94
9139850-7	1997	The gamma-glutamyl acceptor glycylglycine, a co-substrate for gamma-GT, potentiated the growth-inhibitory effect of GSH, which in contrast was decreased by the gamma-GT inhibitors, serine-borate complex and acivicin, suggesting that the production of reactive forms of oxygen (probably H(2)O(2)) was mediated by cysteinyl-glycine after GSH hydrolysis.	Oxygen	269-275	inactive glutathione hydrolase 2	Homo sapiens	62-70
11669688-19	1997	Potential molecular oxygen dissociation pathways involving a spin S = 1 state are discussed.	Oxygen	20-26	spindlin 1	Homo sapiens	61-65
9038135-1	1997	Exposure of rats to hypoxia (7% O2) markedly increased the level of heme oxygenase-1 (HO-1) mRNA in several tissues.	Oxygen	32-34	heme oxygenase 1	Rattus norvegicus	68-84
9038135-1	1997	Exposure of rats to hypoxia (7% O2) markedly increased the level of heme oxygenase-1 (HO-1) mRNA in several tissues.	Oxygen	32-34	heme oxygenase 1	Rattus norvegicus	86-90
9038135-2	1997	Accumulation of HO-1 transcripts was also observed after exposure of rat aortic vascular smooth muscle (VSM) cells to 1% O2, and this induction was dependent on gene transcription.	Oxygen	121-123	heme oxygenase 1	Rattus norvegicus	16-20
9045995-2	1997	The cognition-enhancing drug, nefiracetam ameliorated the acquisition of CRs in older rabbits, protected membrane dysfunction in hippocampal CA1 neurons following oxygen and glucose deprivation, and promoted the release of diverse neurotransmitters, including acetylcholine.	Oxygen	163-169	carbonic anhydrase 1	Oryctolagus cuniculus	141-144
9027733-12	1997	We also found that the genes that encode the c-Fos and JunB transcription factor proteins are regulated by reduced O2 tension.	Oxygen	115-117	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
9027735-0	1997	Diminution of the O2 responsiveness of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocytes by long-term culture at venous PO2.	Oxygen	18-20	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	80-113
9027735-1	1997	The glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene within two hours is modulated by O2 in rat hepatocytes.	Oxygen	119-121	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	41-74
9027735-1	1997	The glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene within two hours is modulated by O2 in rat hepatocytes.	Oxygen	119-121	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	76-79
9027735-4	1997	In arterial O2 precultured cells PCK mRNA and activity were induced to 100% at arterial O2 and to about 60% at venous O2.	Oxygen	12-14	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	33-36
9027735-4	1997	In arterial O2 precultured cells PCK mRNA and activity were induced to 100% at arterial O2 and to about 60% at venous O2.	Oxygen	88-90	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	33-36
9027735-4	1997	In arterial O2 precultured cells PCK mRNA and activity were induced to 100% at arterial O2 and to about 60% at venous O2.	Oxygen	88-90	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	33-36
9027735-5	1997	In venous O2 precultured cells PCK mRNA and activity were induced only to about 70% at arterial O2 and to about 60% at venous O2.	Oxygen	10-12	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
9027735-5	1997	In venous O2 precultured cells PCK mRNA and activity were induced only to about 70% at arterial O2 and to about 60% at venous O2.	Oxygen	96-98	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
9027735-5	1997	In venous O2 precultured cells PCK mRNA and activity were induced only to about 70% at arterial O2 and to about 60% at venous O2.	Oxygen	96-98	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
9027735-6	1997	Transfected PCK promoter (-2500)-CAT constructs were activated by glucagon with the same long-term modulatory effects of oxygen as the endogenous PCK gene.	Oxygen	121-127	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	12-15
9027735-7	1997	Gel mobility shift assays with nuclear extracts prepared from hepatocytes and a PCK promoter fragment ranging from -149 to -42 bp revealed one complex with a higher DNA binding activity when extracts of cells precultured for 24 hours under venous O2 as compared to arterial O2 were used.	Oxygen	247-249	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	80-83
9027735-7	1997	Gel mobility shift assays with nuclear extracts prepared from hepatocytes and a PCK promoter fragment ranging from -149 to -42 bp revealed one complex with a higher DNA binding activity when extracts of cells precultured for 24 hours under venous O2 as compared to arterial O2 were used.	Oxygen	274-276	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	80-83
9027735-8	1997	Therefore, the short-term modulation by O2 of PCK gene activation by glucagon was widely lost during preculture at low O2.	Oxygen	40-42	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	46-49
9027735-8	1997	Therefore, the short-term modulation by O2 of PCK gene activation by glucagon was widely lost during preculture at low O2.	Oxygen	119-121	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	46-49
9027735-9	1997	This diminution of O2 sensitivity of PCK induction may be due to a nuclear protein or proteins which are induced by perivenous O2 tensions and bind to the PCK promoter.	Oxygen	19-21	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	37-40
9027735-9	1997	This diminution of O2 sensitivity of PCK induction may be due to a nuclear protein or proteins which are induced by perivenous O2 tensions and bind to the PCK promoter.	Oxygen	19-21	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	155-158
9027735-9	1997	This diminution of O2 sensitivity of PCK induction may be due to a nuclear protein or proteins which are induced by perivenous O2 tensions and bind to the PCK promoter.	Oxygen	127-129	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	37-40
9027735-9	1997	This diminution of O2 sensitivity of PCK induction may be due to a nuclear protein or proteins which are induced by perivenous O2 tensions and bind to the PCK promoter.	Oxygen	127-129	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	155-158
9006926-4	1997	Under aerobic conditions O2 acts as the electron acceptor and is reduced to produce superoxide (O-2).	Oxygen	25-27	immunoglobulin kappa variable 1D-39	Homo sapiens	96-99
9249941-7	1997	Our results revealed that a high partial oxygen pressure (PO2) level was deleterious to the ultrastructural elements of hepatocytes, in particular to the mitochondria.	Oxygen	41-47	PO2	Sus scrofa	58-61
8962096-9	1996	The capacity of UVA radiation and/or singlet oxygen to induce human gene expression through activation of AP-2 indicates a previously unrecognized role of this transcription factor in the mammalian stress response.	Oxygen	45-51	transcription factor AP-2 alpha	Homo sapiens	106-110
8973661-3	1996	By structure/activity relationship studies of naturally occurring and synthetic diterpene esters of the tigliane type (PKC activators) it is demonstrated that in addition to the oxygen at C20 it is the O-acyl function in position C13 which is critically essential for skin-irritant and tumor-promoting bioactivities rather than other oxygen atoms.	Oxygen	334-340	homeobox C13	Homo sapiens	230-233
8939944-5	1996	In contrast to typical thrombin binding modes, the S2 site of fXa cannot be used by DX-9065a since it is blocked by Tyr-99, and the aryl-binding site (S4) of fXa is lined by carbonyl oxygen atoms that can accommodate positive charges.	Oxygen	183-189	coagulation factor X	Homo sapiens	62-65
8939944-5	1996	In contrast to typical thrombin binding modes, the S2 site of fXa cannot be used by DX-9065a since it is blocked by Tyr-99, and the aryl-binding site (S4) of fXa is lined by carbonyl oxygen atoms that can accommodate positive charges.	Oxygen	183-189	coagulation factor X	Homo sapiens	158-161
8913407-7	1996	Oxidized hemoglobin, methemoglobin, is incapable of reversibly binding oxygen at the physiologic partial oxygen pressure.	Oxygen	71-77	hemoglobin subunit gamma 2	Homo sapiens	21-34
8913407-7	1996	Oxidized hemoglobin, methemoglobin, is incapable of reversibly binding oxygen at the physiologic partial oxygen pressure.	Oxygen	105-111	hemoglobin subunit gamma 2	Homo sapiens	21-34
11666804-4	1996	Thus, the two oxygen-containing ring systems occupied two different sets of positions in the trigonal bipyramid (TBP) with the eight-membered rings at diequatorial sites.	Oxygen	14-20	TATA-box binding protein	Homo sapiens	113-116
8878445-1	1996	The 150-kD oxygen-regulated protein (ORP150) was initially characterized based on its selective expression in astrocytes subjected to oxygen deprivation (Kuwabara, K., M. Matsumoto, J. Ikeda, O. Hori, S. Ogawa, Y. Maeda, K. Kitagawa, N. Imuta, K. Kinoshita, D.M.	Oxygen	11-17	hypoxia up-regulated 1	Homo sapiens	37-43
8900415-5	1996	Results from RNase protection assays and Northern blots showed that the lack of functional HIF-1 complex completely abrogated the response to hypoxia of vascular endothelial growth factor (VEGF) and the glycolytic enzymes aldolase A (ALDA) and phosphoglycerate kinase 1 (PGK-1), genes known to be upregulated by low oxygen tension.	Oxygen	316-322	vascular endothelial growth factor A	Mus musculus	153-187
9242677-2	1997	Here, we present a cell culture model capable of expressing Tf mRNA in an oxygen-dependent manner.	Oxygen	74-80	transferrin	Mus musculus	60-62
9242677-5	1997	Mutation analysis showed that both HBSs function as oxygen-regulated enhancers in Tf-expressing as well as in non-Tf-expressing cell lines.	Oxygen	52-58	transferrin	Mus musculus	82-84
9242677-11	1997	Finally, hypoxic induction of endogenous Tf mRNA was abrogated in Hepa1C4 cells, confirming that HIF-1 confers oxygen regulation of Tf gene expression by binding to the two HBSs present in the Tf enhancer.	Oxygen	111-117	transferrin	Mus musculus	41-43
9242677-11	1997	Finally, hypoxic induction of endogenous Tf mRNA was abrogated in Hepa1C4 cells, confirming that HIF-1 confers oxygen regulation of Tf gene expression by binding to the two HBSs present in the Tf enhancer.	Oxygen	111-117	transferrin	Mus musculus	132-134
9242677-11	1997	Finally, hypoxic induction of endogenous Tf mRNA was abrogated in Hepa1C4 cells, confirming that HIF-1 confers oxygen regulation of Tf gene expression by binding to the two HBSs present in the Tf enhancer.	Oxygen	111-117	transferrin	Mus musculus	132-134
9235969-3	1997	However, an oxygen-insensitive microsomal hydroxylamine reductase consisting of NADH, cytochrome b5, its reductase, and a third unidentified protein component has been known for some time (Kadlubar, F. F., and Ziegler, D. M. (1974) Arch.	Oxygen	12-18	cytochrome b5 type A	Sus scrofa	86-99
9306960-3	1997	Epithelium of normal and inflamed mucosa, and hyperplastic epithelium, showed a residual G6PDH activity (RA) in oxygen that was always less than 20 per cent of the activity in the absence of oxygen.	Oxygen	112-118	glucose-6-phosphate dehydrogenase	Homo sapiens	89-94
9301081-3	1997	An in vitro endosperm culture system has been studied in which o2 endosperm synthesizes 22 kDa zein and b-32 in response to nitrogen supplements.	Oxygen	63-65	Ribosome-inactivating protein 9	Zea mays	104-108
9301081-11	1997	An induction of 22 kDa zein and b-32 synthesis in cultured o2 endosperm could also be achieved on nitrogen-free media by the addition of abscisic acid or methyl jasmonate.	Oxygen	59-61	Ribosome-inactivating protein 9	Zea mays	32-36
9211873-6	1997	Its formation was first order with respect to O2, monophasic, and gave rate constants for kon = 9 x 10(5) M-1 s-1 and koff = 108 s-1 for an L-arginine- and tetrahydrobiopterin (H4B)-saturated nNOSoxy.	Oxygen	46-48	H4 clustered histone 4	Homo sapiens	177-180
8900415-5	1996	Results from RNase protection assays and Northern blots showed that the lack of functional HIF-1 complex completely abrogated the response to hypoxia of vascular endothelial growth factor (VEGF) and the glycolytic enzymes aldolase A (ALDA) and phosphoglycerate kinase 1 (PGK-1), genes known to be upregulated by low oxygen tension.	Oxygen	316-322	vascular endothelial growth factor A	Mus musculus	189-193
2547098-0	1989	[Role of polymorphonuclear leukocytes and oxygen-derived free radicals in the formation of gastric mucosal lesions induced by platelet-activating factor].	Oxygen	42-48	PCNA clamp associated factor	Rattus norvegicus	126-152
8855938-4	1996	The thrombin S2" binding site for Pro-18f, as observed in all three complexes, differs from that predicted by modeling studies and is notable for including two carbonyl oxygens of the thrombin main chain.	Oxygen	169-176	coagulation factor II, thrombin	Bos taurus	4-12
8902948-8	1996	Increase in [Ca2+]i due to oxygen-glucose deprivation was significant in CA1 and CA3 of the septic group and in all hippocampal regions of sham-operated group.	Oxygen	27-33	carbonic anhydrase 3	Rattus norvegicus	81-84
8892348-3	1996	We have identified a novel inflammatory mediator, CAP37 (Cationic Antimicrobial Protein Mi 37 kDa), that promotes mononuclear cell chemotaxis, adhesion of monocytes to endothelium, and release of oxygen radicals from monocytes.	Oxygen	196-202	azurocidin 1	Homo sapiens	50-55
8892348-3	1996	We have identified a novel inflammatory mediator, CAP37 (Cationic Antimicrobial Protein Mi 37 kDa), that promotes mononuclear cell chemotaxis, adhesion of monocytes to endothelium, and release of oxygen radicals from monocytes.	Oxygen	196-202	azurocidin 1	Homo sapiens	57-97
9298245-5	1997	In primary hepatocyte cultures, glucagon activated the phosphoenolpyruvate carboxykinase (PCK) gene to higher levels under arterial than under venous oxygen.	Oxygen	150-156	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	55-88
9298245-5	1997	In primary hepatocyte cultures, glucagon activated the phosphoenolpyruvate carboxykinase (PCK) gene to higher levels under arterial than under venous oxygen.	Oxygen	150-156	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	90-93
9298245-7	1997	Exogenously added hydrogen peroxide mimicked the effects of arterial oxygen on both the glucagon-dependent PCK gene and the insulin-dependent GK activation.	Oxygen	69-75	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	107-110
9298245-9	1997	This notion was corroborated by the finding that CO mimicked the positive effect of O2 on PCK gene activation.	Oxygen	84-86	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	90-93
9298245-10	1997	Transfection of PCK promoter-CAT gene constructs into primary hepatocytes showed that the oxygen modulation of the PCK gene activation occurred in the region -281/+69.	Oxygen	90-96	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	16-19
9298245-10	1997	Transfection of PCK promoter-CAT gene constructs into primary hepatocytes showed that the oxygen modulation of the PCK gene activation occurred in the region -281/+69.	Oxygen	90-96	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	115-118
9298245-13	1997	Oxidative conditions such as H2O2 reduced the DNA-binding activity, thus supporting the role of H2O2 as a mediator in the O2 response of the PCK and GK genes.	Oxygen	31-33	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	141-144
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	119-121	cytochrome c oxidase subunit VII	Saccharomyces cerevisiae S288C	37-41
9169434-6	1997	For some aerobic genes (COX4, COX5a, COX7, COX8, and COX9) there is a gradual decline in expression between 200 microM O2 (air) and their oxygen threshold.	Oxygen	138-144	cytochrome c oxidase subunit VII	Saccharomyces cerevisiae S288C	37-41
9202484-5	1997	DNA mobility shift and footprint analyses showed that only the tsp proximal site was bound by pure Crp with a Kd of 5.4 x 10(-7) M. As shown by an Arc-defective strain, the aldA gene seems to be repressed by the Arc system under anaerobiosis, displaying its physiological full induction and activity in the presence of oxygen.	Oxygen	319-325	catabolite gene activator protein	Escherichia coli	99-102
8865272-11	1996	Oxygen exposure increased NSP in BAL and decreased the ability of BAL to inhibit lipid peroxidation as measured by malondialdehyde (MDA) generation compared with RA exposure.	Oxygen	0-6	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	26-29
2547098-6	1989	These results suggest that oxygen-derived free radicals produced by PMN and lipid peroxidation may play an important role in the pathogenesis of gastric mucosal injury induced by PAF.	Oxygen	27-33	PCNA clamp associated factor	Rattus norvegicus	179-182
2541771-4	1989	Active oxygen produced extracellularly by xanthine-xanthine oxidase and the methylating agent N-methyl-N"-nitro-N-nitrosoguanidine transiently increased the level of poly(ADPR) substitution of these enzymes by a factor of 6-10.	Oxygen	7-13	xanthine dehydrogenase	Mus musculus	51-67
8774724-0	1996	Transcription of the AAC1 gene encoding an isoform of mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is regulated by oxygen in a heme-independent manner.	Oxygen	128-134	ADP/ATP carrier protein AAC1	Saccharomyces cerevisiae S288C	21-25
8774724-4	1996	By monitoring the level of AAC1 mRNA and the beta-galactosidase activity of AAC1-lacZ fusion constructs, we showed that expression of AAC1 is subjected to regulation by oxygen.	Oxygen	169-175	ADP/ATP carrier protein AAC1	Saccharomyces cerevisiae S288C	27-31
8774724-4	1996	By monitoring the level of AAC1 mRNA and the beta-galactosidase activity of AAC1-lacZ fusion constructs, we showed that expression of AAC1 is subjected to regulation by oxygen.	Oxygen	169-175	ADP/ATP carrier protein AAC1	Saccharomyces cerevisiae S288C	76-80
8774724-4	1996	By monitoring the level of AAC1 mRNA and the beta-galactosidase activity of AAC1-lacZ fusion constructs, we showed that expression of AAC1 is subjected to regulation by oxygen.	Oxygen	169-175	ADP/ATP carrier protein AAC1	Saccharomyces cerevisiae S288C	76-80
8774724-5	1996	In contrast to the other two AAC genes, the effect of oxygen on AAC1 is not mediated by heme and heme-dependent transcription factors.	Oxygen	54-60	ADP/ATP carrier protein AAC1	Saccharomyces cerevisiae S288C	64-68
9177307-1	1997	Cytochrome b558 is a component of the superoxide-generating system in neutrophils and plays key roles in both the assembly of a functional complex with cytosolic proteins and shuttling an electron from NADPH to molecular oxygen.	Oxygen	221-227	mitochondrially encoded cytochrome b	Homo sapiens	0-12
9160838-10	1997	Animals exposed to 100% oxygen for an average of 9 days had an 80% decrease in lung VEGF mRNA abundance, decreased alveolar epithelial cell VEGF expression, and decreased VEGF immunostaining.	Oxygen	24-30	vascular endothelial growth factor A	Oryctolagus cuniculus	84-88
9160838-10	1997	Animals exposed to 100% oxygen for an average of 9 days had an 80% decrease in lung VEGF mRNA abundance, decreased alveolar epithelial cell VEGF expression, and decreased VEGF immunostaining.	Oxygen	24-30	vascular endothelial growth factor A	Oryctolagus cuniculus	140-144
9160838-10	1997	Animals exposed to 100% oxygen for an average of 9 days had an 80% decrease in lung VEGF mRNA abundance, decreased alveolar epithelial cell VEGF expression, and decreased VEGF immunostaining.	Oxygen	24-30	vascular endothelial growth factor A	Oryctolagus cuniculus	140-144
9160838-13	1997	Furthermore, hyperoxic injury decreases neonatal lung VEGF mRNA and protein, which may be a contributory mechanism of impaired postnatal microvascular development in oxygen injury.	Oxygen	166-172	vascular endothelial growth factor A	Oryctolagus cuniculus	54-58
2696317-1	1989	We report one case of severe accidental hypothermia; rectal temperature was 25 degrees C. Hypoxemia unmodified by 100 O2 inhalation in an ordinary face-mask was easily corrected using a face-mask CPAP; a ventilation-perfusion mismatching could be implicated in the cold induced hypoxemia.	Oxygen	118-120	centromere protein J	Homo sapiens	196-200
9237422-8	1997	Thus it seems that by replacing C-2 by an oxygen atom we can reduce the biological damage caused by relatively high concentrations of steroid treatment.	Oxygen	42-48	complement C2	Bos taurus	32-35
9125493-1	1997	The kinetic mechanism of urate oxidase isolated from soybean root nodules has been determined by initial velocity kinetic studies monitoring oxygen uptake, in order to avoid potential artifacts in the spectrophotometric assay which arise from absorbance due to unidentified products of the enzymatic reaction.	Oxygen	141-147	uricase-2 isozyme 2	Glycine max	25-38
9142947-8	1997	Whole lung SP-A mRNA expression (measured by membrane hybridization) was twice control levels at 4 days of &gt;95% O2, with specific elevations in terminal bronchioles and type II cells at 4 days and the LD50 by in situ hybridization.	Oxygen	115-117	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	11-15
9120261-3	1997	Blood leukocytes differentially express two additional IgG FcR, Fc gamma RI (CD64) and Fc gamma RIII (CD16), which may also participate in leukocyte functions such as phagocytosis, Ab-dependent cellular cytotoxicity (ADCC), release of oxygen intermediates, and enhancement of Ag presentation.	Oxygen	235-241	Fc gamma receptor IIIa	Homo sapiens	87-100
9120261-3	1997	Blood leukocytes differentially express two additional IgG FcR, Fc gamma RI (CD64) and Fc gamma RIII (CD16), which may also participate in leukocyte functions such as phagocytosis, Ab-dependent cellular cytotoxicity (ADCC), release of oxygen intermediates, and enhancement of Ag presentation.	Oxygen	235-241	Fc gamma receptor IIIa	Homo sapiens	102-106
9098846-4	1997	To determine the expression of decorin in normal and oxygen-injured lung, newborn rats were exposed to hyperoxia for 6 wk.	Oxygen	53-59	decorin	Rattus norvegicus	31-38
9098846-7	1997	Oxygen exposure is associated with a 77% reduction in decorin mRNA in whole lung and a decrease in decorin immunoreactivity in connective tissues surrounding large airways and blood vessels, but an increase in decorin mRNA and protein expression at the tips of alveolar septa.	Oxygen	0-6	decorin	Rattus norvegicus	54-61
9098846-7	1997	Oxygen exposure is associated with a 77% reduction in decorin mRNA in whole lung and a decrease in decorin immunoreactivity in connective tissues surrounding large airways and blood vessels, but an increase in decorin mRNA and protein expression at the tips of alveolar septa.	Oxygen	0-6	decorin	Rattus norvegicus	99-106
9098846-7	1997	Oxygen exposure is associated with a 77% reduction in decorin mRNA in whole lung and a decrease in decorin immunoreactivity in connective tissues surrounding large airways and blood vessels, but an increase in decorin mRNA and protein expression at the tips of alveolar septa.	Oxygen	0-6	decorin	Rattus norvegicus	99-106
9098846-11	1997	It is likely that regional changes in lung decorin expression are influenced by factors produced and acting locally, and that such changes may contribute to the morphologic alterations characteristic of oxygen-induced lung injury.	Oxygen	203-209	decorin	Rattus norvegicus	43-50
8690413-4	1996	Although TAA treatment for 4 weeks had no effect on oxygen consumption or hepatic portal pressure in the perfused liver, the increment in hepatic portal pressure and decrement in oxygen consumption induced by PAF in TAA-treated rats were double those in control rats.	Oxygen	179-185	PCNA clamp associated factor	Rattus norvegicus	209-212
8690093-5	1996	PCK mRNA was induced by glucagon maximally under arterial O2 and only half maximally under venous O2.	Oxygen	58-60	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
8690093-5	1996	PCK mRNA was induced by glucagon maximally under arterial O2 and only half maximally under venous O2.	Oxygen	98-100	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
8690093-7	1996	H2O2 enhanced the induction of PCK mRNA to similar levels under venous O2 tensions and the induction of ALD A mRNA under both O2 was completely inhibited.	Oxygen	2-4	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
8690093-7	1996	H2O2 enhanced the induction of PCK mRNA to similar levels under venous O2 tensions and the induction of ALD A mRNA under both O2 was completely inhibited.	Oxygen	71-73	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
8764218-4	1996	Hypoxic cells that were subsequently reoxygenated in 21% O2 also demonstrated a similar increase in XDH/XO activity vs. timed controls.	Oxygen	57-59	xanthine dehydrogenase	Bos taurus	100-103
9026352-1	1996	Aerobic and anaerobic studies have demonstrated that uroporphyrin I-induced inactivation of delta-aminolevulinic acid dehydratase, porphobilinogenase, deaminase and uroporphyrinogen decarboxylase was dependent on oxygen and mediated by reactive oxygen species.	Oxygen	213-219	aminolevulinate dehydratase	Homo sapiens	92-129
8676867-3	1996	The results of this study showed that PPDK activity is detectable in wild-type maize endosperms, while in o2 mutant endosperms, the levels of PPDK protein, mRNA and enzymatic activity are reduced, indicating that O2 is involved in the regulation of cyPPDK1 in this tissue.	Oxygen	213-215	regulatory protein opaque-2	Zea mays	106-108
8617779-12	1996	These data suggest that astroglia respond to oxygen deprivation by redirection of protein synthesis with the appearance of a novel stress protein, ORP150.	Oxygen	45-51	hypoxia up-regulated 1	Rattus norvegicus	147-153
8593060-5	1996	Less repression was found under conditions of ammonium or oxygen limitation (2 to 10% and 20 to 35%, respectively, of the BADH levels under succinate limitation).	Oxygen	58-64	benzyl alcohol dehydrogenase	Pseudomonas putida	122-126
8919448-5	1996	A third E. coli nitrate reductase, NarZYWV, and the poorly expressed formate dehydrogenase O possibly facilitate rapid adaptation to oxygen starvation pending the synthesis of the major respiratory formate-nitrate oxidoreductase.	Oxygen	133-139	oxidoreductase	Escherichia coli	214-228
8824885-2	1996	In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development.	Oxygen	129-131	glutathione peroxidase 1	Homo sapiens	177-181
9090846-0	1996	Oxygen- and carbon source-dependent transactivation effect of ABF1 on the expression of the AAC2 gene encoding mitochondrial ADP/ATP carrier.	Oxygen	0-6	solute carrier family 25 member 5	Homo sapiens	92-96
8573290-1	1995	Two different enzymes that metabolize lactate in the presence of oxygen, either to acetate plus CO2 (lactate 2-mono-oxygenase; Lmox) or to pyruvate plus H2O2 (lactate oxidase; Lox) were encapsulated in human and murine red blood cells (RBCs).	Oxygen	65-71	lysyl oxidase	Homo sapiens	176-179
8536713-6	1995	We report that the DNA-binding and transcriptional activity of transcription factor AP-1 is very strongly induced in a biphasic response when HeLa cells are exposed to reduced oxygen pressure.	Oxygen	176-182	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-88
8786668-7	1995	DNA polymerase beta activities in 3W rats decreased up to 48 h with oxygen exposure, but recovered to pre-exposure levels by 72 h. Moreover, an induction of DNA polymerase gamma, which is related to mitochondrial DNA (mtDNA) replication and/or repair, was observed only in 3W rat lungs after 24 h of oxygen exposure.	Oxygen	68-74	DNA polymerase gamma, catalytic subunit	Rattus norvegicus	157-177
8786668-7	1995	DNA polymerase beta activities in 3W rats decreased up to 48 h with oxygen exposure, but recovered to pre-exposure levels by 72 h. Moreover, an induction of DNA polymerase gamma, which is related to mitochondrial DNA (mtDNA) replication and/or repair, was observed only in 3W rat lungs after 24 h of oxygen exposure.	Oxygen	300-306	DNA polymerase gamma, catalytic subunit	Rattus norvegicus	157-177
8786668-8	1995	From these results, we conclude that the induction of DNA polymerase beta and DNA polymerase gamma in lung tissue plays a key role in oxygen tolerance in very young rats.	Oxygen	134-140	DNA polymerase gamma, catalytic subunit	Rattus norvegicus	78-98
24301585-6	1995	The S2-state multiline signal, the oxygen evolution and photooxidation of the high potential form of cytochrome b-559 were inhibited approximately with the same kinetics as the g=1.9 signal.	Oxygen	35-41	mitochondrially encoded cytochrome b	Homo sapiens	101-113
7565686-5	1995	Results showed that under nonstressed conditions, VEGF shares with the glucose transporter GLUT-1 a relatively short half-life (0.64 and 0.52 h, respectively), which is extended fourfold and more than eightfold, respectively, when cells are deprived of either oxygen or glucose.	Oxygen	260-266	solute carrier family 2 member 1	Homo sapiens	91-97
7646492-0	1995	Modulation of hemopexin gene expression by physiological oxygen tensions in primary rat hepatocyte cultures.	Oxygen	57-63	hemopexin	Rattus norvegicus	14-23
7646492-2	1995	To investigate whether the Hx gene is activated by oxygen as such or via H2O2 as an oxygen signal transmitter the effects of arterial and venous O2 tensions as well as different concentrations of H2O2 on Hx mRNA expression were studied.	Oxygen	51-57	hemopexin	Rattus norvegicus	27-29
7646492-2	1995	To investigate whether the Hx gene is activated by oxygen as such or via H2O2 as an oxygen signal transmitter the effects of arterial and venous O2 tensions as well as different concentrations of H2O2 on Hx mRNA expression were studied.	Oxygen	84-90	hemopexin	Rattus norvegicus	27-29
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	64-66	hemopexin	Rattus norvegicus	73-75
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	140-142	hemopexin	Rattus norvegicus	73-75
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	140-142	hemopexin	Rattus norvegicus	73-75
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	140-142	hemopexin	Rattus norvegicus	73-75
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	140-142	hemopexin	Rattus norvegicus	73-75
7646492-3	1995	After preculturing primary rat hepatocytes for 24 h at arterial O2 (16%) Hx mRNA was expressed with a maximal level (= 100%), when arterial O2 tension proceeded for 2 h, and to values of approximately 50%, when venous O2 tension (8%) proceeded for 2 h. When hepatocytes were precultured for 24 h under venous O2, Hx mRNA was induced by arterial O2 to values of 60% and under venous O2 to values of approximately 35%.	Oxygen	140-142	hemopexin	Rattus norvegicus	73-75
7646492-6	1995	The results suggest that O2 per se rather than the reactive oxygen intermediate H2O2 modulates Hx expression.	Oxygen	25-27	hemopexin	Rattus norvegicus	95-97
7601557-0	1995	The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells.	Oxygen	21-27	xanthine dehydrogenase	Mus musculus	50-66
7788904-7	1995	Exposure of VSMCs to a threshold hypoxic stimulus (2.5% O2) caused a modest increase in VEGF mRNA levels.	Oxygen	56-58	vascular endothelial growth factor A	Oryctolagus cuniculus	88-92
7556471-6	1995	From fitting PO2 profiles measured in the dark-adapted retina to a three-layer diffusion model, O2 consumption was found to be 1.0 +/- 0.4 and 0.4 +/- 0.3 ml O2 (100 g min)-1 in the outer and inner halves of the retina, respectively.	Oxygen	14-16	immunoglobulin kappa variable 1D-39	Homo sapiens	158-174
7556472-6	1995	The increase in oxygen utilization in lowered [Na+] was suppressed by adding 0.7 mM 3-isobutyl-1-methyl-xanthine, a phosphodiesterase inhibitor, suggesting that the response was largely due to hydrolysis and subsequent resynthesis of cyclic GMP.	Oxygen	16-22	5'-nucleotidase, cytosolic II	Homo sapiens	241-244
7556472-7	1995	Results of fitting the light-evoked responses to exponential functions suggested that the decrease in oxygen consumption caused by slowing of the photoreceptor Na+/K+ ATPase had a time constant between 130 and 180 sec and that the increase in oxygen utilization from increased cyclic GMP synthesis was faster.	Oxygen	102-108	5'-nucleotidase, cytosolic II	Homo sapiens	284-287
7556472-7	1995	Results of fitting the light-evoked responses to exponential functions suggested that the decrease in oxygen consumption caused by slowing of the photoreceptor Na+/K+ ATPase had a time constant between 130 and 180 sec and that the increase in oxygen utilization from increased cyclic GMP synthesis was faster.	Oxygen	243-249	5'-nucleotidase, cytosolic II	Homo sapiens	284-287
7647918-4	1995	We found (1) the formation of luteoskyrin semiquinone radical in the NADPH-cytochrome P-450 reductase system under anaerobic conditions, (2) the generation of O2- in the systems composed of luteoskyrin, NAD(P)H, and either rat liver microsomal NADPH-cytochrome P-450 reductases or submitochondrial particles and (3) dicoumarol showed no effect on the O2- generation in the case of submitochondrial particles.	Oxygen	159-161	cytochrome p450 oxidoreductase	Rattus norvegicus	69-101
2595310-3	1989	These results suggest that PAF generated on hypoxia might stimulate oxygen radical production by neutrophils, resulting in the occurrence of gastric injury in hemorrhagic shock rats.	Oxygen	68-74	PCNA clamp associated factor	Rattus norvegicus	27-30
7790760-2	1995	CAP37 was initially recognized for its strong antibiotic activity against Gram-negative bacteria and was viewed as a component of the oxygen-independent killing mechanism of the neutrophil.	Oxygen	134-140	azurocidin 1	Homo sapiens	0-5
9079661-0	1997	The reaction of reduced xanthine dehydrogenase with molecular oxygen.	Oxygen	62-68	xanthine dehydrogenase	Bos taurus	24-46
9079661-2	1997	Xanthine dehydrogenase (XDH) from bovine milk contains significant activity in xanthine/oxygen turnover assays.	Oxygen	88-94	xanthine dehydrogenase	Bos taurus	0-22
9079661-2	1997	Xanthine dehydrogenase (XDH) from bovine milk contains significant activity in xanthine/oxygen turnover assays.	Oxygen	88-94	xanthine dehydrogenase	Bos taurus	24-27
9079661-3	1997	The oxidative half-reaction of XDH with molecular oxygen has been studied in detail, at 25 degrees C, pH 7.5, to determine the basis of the preference of XDH for NAD over oxygen as oxidizing substrate.	Oxygen	50-56	xanthine dehydrogenase	Bos taurus	31-34
9079661-3	1997	The oxidative half-reaction of XDH with molecular oxygen has been studied in detail, at 25 degrees C, pH 7.5, to determine the basis of the preference of XDH for NAD over oxygen as oxidizing substrate.	Oxygen	50-56	xanthine dehydrogenase	Bos taurus	154-157
9079661-3	1997	The oxidative half-reaction of XDH with molecular oxygen has been studied in detail, at 25 degrees C, pH 7.5, to determine the basis of the preference of XDH for NAD over oxygen as oxidizing substrate.	Oxygen	171-177	xanthine dehydrogenase	Bos taurus	31-34
9079661-3	1997	The oxidative half-reaction of XDH with molecular oxygen has been studied in detail, at 25 degrees C, pH 7.5, to determine the basis of the preference of XDH for NAD over oxygen as oxidizing substrate.	Oxygen	171-177	xanthine dehydrogenase	Bos taurus	154-157
9079661-6	1997	Reduced XDH reacts with oxygen in at least 4 bi-molecular steps, with 1.7-1.9 mol of superoxide per mol of XDH formed from the last 2 electrons oxidized.	Oxygen	24-30	xanthine dehydrogenase	Bos taurus	8-11
9016625-1	1997	The maize (Zea mays L.) endosperm specific transcription factor, encoded by the Opaque-2(O2) locus, functions in vivo to activate transcription from its target promoters.O2 regulates the expression of a major storage protein class, the 22 kDa zeins, and of a type I ribosome inactivating protein, b-32, during maturation phase endosperm development.	Oxygen	89-91	regulatory protein opaque-2	Zea mays	80-88
9016625-1	1997	The maize (Zea mays L.) endosperm specific transcription factor, encoded by the Opaque-2(O2) locus, functions in vivo to activate transcription from its target promoters.O2 regulates the expression of a major storage protein class, the 22 kDa zeins, and of a type I ribosome inactivating protein, b-32, during maturation phase endosperm development.	Oxygen	89-91	Ribosome-inactivating protein 9	Zea mays	297-301
9027726-11	1997	In these cells, cytochrome b558 as part of an NADPH oxidase may be involved in a presumptive oxygen sensing mechanism using H2O2 as a possible second messenger for EPO gene regulation.	Oxygen	93-99	cytochrome b, mitochondrial	Rattus norvegicus	16-28
7748884-1	1995	Purified cytochrome b-559 reconstituted into liposomes, consisting of certain azolectin-based phospholipid mixtures, is capable of NADPH-supported FAD-dependent superoxide (O2-) production in the absence of cytosolic activators.	Oxygen	173-175	mitochondrially encoded cytochrome b	Homo sapiens	9-21
7748884-5	1995	In the present report, representing an extension of our earlier investigations, two types of vesicle-incorporated and reflavinated cytochrome b-559 preparation were distinguished by their ability to catalyze vectorial electrogenic or scalar electron transport from NADPH to oxygen.	Oxygen	274-280	mitochondrially encoded cytochrome b	Homo sapiens	131-143
7748884-6	1995	This can be explained by the existence of two distinct membranal locations of cytochrome b-559, with NADPH-binding and O2-reducing sites exposed on different or on the same side of the membrane.	Oxygen	119-121	mitochondrially encoded cytochrome b	Homo sapiens	78-90
7771804-3	1995	In oxygen-pulse experiments, the alcohol oxidation (induced by the addition of alcohol dehydrogenase) was used to mimic a cytosolic source of reducing equivalents.	Oxygen	3-9	aldo-keto reductase family 1 member A1	Homo sapiens	79-100
9027727-10	1997	In response to an external application of NADH (1 mM), the membrane bound cytochrome b558 produces two times more O2- than to the external NADPH (1 mM) application.	Oxygen	114-116	mitochondrially encoded cytochrome b	Homo sapiens	74-86
9027741-4	1997	Hypoxic induction of the vascular endothelial growth factor (VEGF) gene, however, was only partially abrogated in Hepa1C4 cells, suggesting that HIF-1-independent oxygen signaling pathways might exist.	Oxygen	163-169	vascular endothelial growth factor A	Mus musculus	25-59
2489384-0	1989	[Oxygen metabolism in roots resorbing granulated tissue from bovine deciduous teeth, from the aspects of superoxide dismutase, lactate dehydrogenase, and lipid peroxidation].	Oxygen	1-7	LDH	Bos taurus	127-148
9027741-4	1997	Hypoxic induction of the vascular endothelial growth factor (VEGF) gene, however, was only partially abrogated in Hepa1C4 cells, suggesting that HIF-1-independent oxygen signaling pathways might exist.	Oxygen	163-169	vascular endothelial growth factor A	Mus musculus	61-65
7762622-2	1995	Because this inhibition occurs via phospholipase A2 activation, a pathway stimulated by hypoxia, we evaluated the influence of oxygen supply on PKC action on Na(+)-K(+)-ATPase.	Oxygen	127-133	protein kinase C, gamma	Rattus norvegicus	144-147
3193210-5	1988	Total radiopharmaceutical absorbed dose estimates necessary to measure cerebral oxygen metabolism in a 3.51-kg infant based on 0.7 mCi/kg H2(15)O and 1 mCi/kg C15O and O15O were determined to be 1.6 rad to the lung (maximum organ dose), 0.28 rad to the marrow, 0.46 rad to the gonads, and 0.22 rad to total body.	Oxygen	80-86	A-kinase anchoring protein 5	Homo sapiens	138-151
7724734-1	1995	We investigated the role of reactive oxygen intermediates and protein kinase C in the induction of expression of the c-jun gene in human ML-2 leukemic cells and normal human DET-551 fibroblasts by comparing the effects of exposure to either ionizing radiation or H2O2 in the presence or absence of appropriate inhibitors.	Oxygen	37-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
7713877-1	1995	Phagocytic cytochrome b558 is a unique heme-containing enzyme, which catalyzes one electron reduction of molecular oxygen to produce a superoxide anion with a six-coordinated heme iron.	Oxygen	115-121	mitochondrially encoded cytochrome b	Homo sapiens	11-23
7713877-3	1995	Reduced cytochrome b558 was rapidly reoxidized by O2 showing spectral changes with clear isosbestic points, which were also observed during the reduction of ferric cytochrome b558 with Na2S2O4 under anaerobic conditions.	Oxygen	50-52	mitochondrially encoded cytochrome b	Homo sapiens	8-20
8999974-9	1997	Thus, we named it KDRF (KM-102-derived reductase-like factor), and KDRF may play a role in scavenging reactive oxygen intermediates, which are possibly toxic to cells, in response to inflammatory stimuli.	Oxygen	111-117	thioredoxin reductase 1	Homo sapiens	18-22
8999974-9	1997	Thus, we named it KDRF (KM-102-derived reductase-like factor), and KDRF may play a role in scavenging reactive oxygen intermediates, which are possibly toxic to cells, in response to inflammatory stimuli.	Oxygen	111-117	thioredoxin reductase 1	Homo sapiens	24-60
8999974-9	1997	Thus, we named it KDRF (KM-102-derived reductase-like factor), and KDRF may play a role in scavenging reactive oxygen intermediates, which are possibly toxic to cells, in response to inflammatory stimuli.	Oxygen	111-117	thioredoxin reductase 1	Homo sapiens	67-71
9083640-3	1997	Therefore, the present study was designed to investigate the effects of various free-Hb based oxygen carrying solutions on the intracellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and also von Willebrand factor (vWF) expression by human endothelium.	Oxygen	94-100	intercellular adhesion molecule 1	Homo sapiens	127-160
7713877-6	1995	Under complete anaerobic conditions, ferrous cytochrome b558 was oxidized by ferricyanide at a rate faster than by O2.	Oxygen	115-117	mitochondrially encoded cytochrome b	Homo sapiens	45-57
9083640-3	1997	Therefore, the present study was designed to investigate the effects of various free-Hb based oxygen carrying solutions on the intracellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and also von Willebrand factor (vWF) expression by human endothelium.	Oxygen	94-100	intercellular adhesion molecule 1	Homo sapiens	162-168
3054271-2	1988	As the thick ascending limb of Henle"s loop (TAL-segment) is able to glycolyse anaerobically, a phase of oxygen deficiency may be bridgespanned.	Oxygen	105-111	transaldolase 1	Homo sapiens	45-48
9452788-5	1997	These results suggest that NAC might act as a scavenger of oxygen-derived free radicals released by stimulated neutrophils and thereby protect the tissue against the radical caused injury as well as optimize phagocytosis.	Oxygen	59-65	X-linked Kx blood group	Homo sapiens	27-30
7609581-4	1995	At 30 min of oxygen/glucose deprivation cells in the CA1 area were relatively more sensitive compared to CA3 and dentate gyrus cells, with respect to the time course of degeneration and the percentage of affected cells.	Oxygen	13-19	carbonic anhydrase 1	Homo sapiens	53-56
7884306-4	1995	The monoclonal anti-ICAM-1 antibody 1A29, but not an immunoglobulin G control antibody, administered at 1 h and 8 h of reperfusion (2 mg/kg) significantly attenuated liver injury as indicated by 51% lower plasma alanine aminotransferase activities and 32-36% less hepatic necrosis at 24 h without affecting reactive oxygen formation by Kupffer cells and hepatic neutrophils.	Oxygen	316-322	intercellular adhesion molecule 1	Rattus norvegicus	20-26
8986122-11	1997	The carbonyl oxygen atom of the Boc group is the first acceptor whereas the carbonyl oxygen atom of Val4 is the last acceptor in the helical structure of the peptide.	Oxygen	13-19	BOC cell adhesion associated, oncogene regulated	Homo sapiens	32-35
9585973-2	1997	From CD and NOE spectra, anomalous syn orientation of Urd-5"-NH2 might be caused by specific interaction between borates and Urd-5"-NH2, which promote the formation of hydrogen bonding between 2-carbonyl oxygen and hydrogen of 5"-amino group.	Oxygen	204-210	synemin	Homo sapiens	35-38
3054271-4	1988	If oxygen capacity is reduced systematically, which can be effected in the isolated kidney model by using cell free perfusate, a typical pattern of lesions occur in TAL-segments.	Oxygen	3-9	transaldolase 1	Homo sapiens	165-168
7793181-12	1995	Below an intestinal O2 uptake of 2.5 ml min-1, pHi correlated somewhat better with O2 uptake (r = 0.66) than did arterial base excess (r = 0.50).	Oxygen	20-22	glucose-6-phosphate isomerase	Oryctolagus cuniculus	47-50
3075657-0	1988	The effect of dissolved oxygen concentration on the growth physiology of Saccharomyces cerevisiae whi2 mutants.	Oxygen	24-30	Whi2p	Saccharomyces cerevisiae S288C	98-102
7793181-12	1995	Below an intestinal O2 uptake of 2.5 ml min-1, pHi correlated somewhat better with O2 uptake (r = 0.66) than did arterial base excess (r = 0.50).	Oxygen	83-85	glucose-6-phosphate isomerase	Oryctolagus cuniculus	47-50
8956748-6	1996	Oxygen saturation (percentage of oxygenated hemoglobin) was calculated as the difference between the 2 light intensities (860-750 nm) with the use of 2 time periods: preoperative (80%) oxygen saturation and during arterial occlusion (0%) oxygen saturation with NIRS.	Oxygen	0-6	HGB	Sus scrofa	44-54
8956748-6	1996	Oxygen saturation (percentage of oxygenated hemoglobin) was calculated as the difference between the 2 light intensities (860-750 nm) with the use of 2 time periods: preoperative (80%) oxygen saturation and during arterial occlusion (0%) oxygen saturation with NIRS.	Oxygen	33-39	HGB	Sus scrofa	44-54
3220441-3	1988	P50, (oxygen tension at which the hemoglobin is 50% saturated with oxygen) is recognized as one of the factors affecting oxygen supply to the tissue.	Oxygen	6-12	activating signal cointegrator 1 complex subunit 1	Homo sapiens	0-3
8990625-6	1996	Anti-CD11b mAb stimulated O2- production in a PMN cell suspension.	Oxygen	26-28	integrin subunit alpha M	Homo sapiens	5-10
22358634-4	1995	It is assumed that oxygen consumption is 10(-16) mole O(2) cell(-1) s(-1), while mass transfer coefficients are obtained from Sherwood relations.	Oxygen	19-25	carboxyl ester lipase pseudogene	Homo sapiens	59-66
7549522-4	1995	This study examined the effect of recombinant soluble ICAM-1 and its ligands on eosinophil-induced radical oxygen products in terms of luminol-dependent chemiluminescence.	Oxygen	107-113	intercellular adhesion molecule 1	Homo sapiens	54-60
3220441-3	1988	P50, (oxygen tension at which the hemoglobin is 50% saturated with oxygen) is recognized as one of the factors affecting oxygen supply to the tissue.	Oxygen	67-73	activating signal cointegrator 1 complex subunit 1	Homo sapiens	0-3
8904676-9	1996	Mean oxygen saturation was significantly decreased in patients with SRBD (95.2 +/- 1.8 vs. 96.2 +/- 1.42%, p &lt; 0.05), and positively correlated with the pNN &gt; 50 (r = 0.34, p &lt; 0.01).	Oxygen	5-11	pinin, desmosome associated protein	Homo sapiens	156-159
3220441-3	1988	P50, (oxygen tension at which the hemoglobin is 50% saturated with oxygen) is recognized as one of the factors affecting oxygen supply to the tissue.	Oxygen	67-73	activating signal cointegrator 1 complex subunit 1	Homo sapiens	0-3
8560091-2	1995	Cystic fibrosis (CF) and oxygen toxicity were chosen as conditions that might show altered elastin destruction.	Oxygen	25-31	elastin	Homo sapiens	91-98
2833923-1	1988	The assignment of cytochrome b-558 as a component of the O2- (H2O2) -generating enzyme in guinea-pig alveolar macrophages was investigated.	Oxygen	57-59	cytochrome b	Cavia porcellus	18-30
7535686-4	1994	Neutrophil numbers in bronchoalveolar lavage fluid peaked after 60 hr of exposure to s 95% oxygen; this was associated with a marked upregulation of mRNA for the adhesion molecules P-selectin and E-selectin but not VCAM-1.	Oxygen	91-97	selectin E	Rattus norvegicus	196-206
7535686-5	1994	mRNA for ICAM-1 was constitutively expressed at high levels in both air-breathing controls and in the lungs of rats exposed to high concentrations of oxygen.	Oxygen	150-156	intercellular adhesion molecule 1	Rattus norvegicus	9-15
2833923-3	1988	The rate of myristic acid-stimulated O2- generation by alveolar macrophages, calculated per cytochrome b-558, was only one-fourth that of neutrophils.	Oxygen	37-39	cytochrome b	Cavia porcellus	92-104
3293479-4	1988	Under halothane-N2O/O2 anesthesia free T4 rose initially also, here represented by T4/TBG-ratio (= FTI).	Oxygen	20-22	serpin family A member 7	Homo sapiens	86-89
7880447-1	1994	The CA1 and hilar fields of the hippocampus are highly vulnerable to lack of oxygen after interruption of blood flow to the brain.	Oxygen	77-83	carbonic anhydrase 1	Homo sapiens	4-7
8910370-1	1996	We have previously reported that hydrogen peroxide, an active oxygen species and a cellular oxidant, induces c-Fos and c-Jun mRNA expression and DNA synthesis in vascular smooth muscle cells and that these events require arachidonic acid release and metabolism through the lipoxygenase pathway.	Oxygen	62-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-114
3358265-6	1988	A model in which X1 accumulated in proportion to the PO2 and disappeared by first-order decay during periods of low O2 exposure was modified to include an effective rate constant for changes in X1: dX1/dt = a.PO2 + K1.	Oxygen	54-56	x1	Drosophila melanogaster	17-19
8887660-1	1996	Oxygen toxicity in Saccharomyces cerevisiae lacking the copper/zinc superoxide dismutase (SOD1) can be suppressed by overexpression of the S. cerevisiae ATX2 gene.	Oxygen	0-6	Mn(2+) transporter ATX2	Saccharomyces cerevisiae S288C	153-157
8887660-2	1996	Multiple copies of ATX2 were found to reverse the aerobic auxotrophies of sod1(delta) mutants for lysine and methionine and also to enhance the resistance of these yeast strains to paraquat and atmospheric levels of oxygen.	Oxygen	216-222	Mn(2+) transporter ATX2	Saccharomyces cerevisiae S288C	19-23
8887660-10	1996	The effect of ATX2 overexpression on manganese accumulation and oxygen resistance is similar to what we have previously reported for mutations in PMR1, which encodes a manganese-trafficking protein that also resides in a vesicular compartment.	Oxygen	64-70	Mn(2+) transporter ATX2	Saccharomyces cerevisiae S288C	14-18
7979393-4	1994	We previously reported that hypotonic treatment reversibly enhanced O2- production stimulated by PKC activators in intact neutrophils (M. Hiura et al., 1991, Arch.	Oxygen	68-70	Prkca	Cavia porcellus	97-100
7979393-12	1994	In the presence of SDS, addition of 1-oleoyl-2-acetylglycerol, a PKC activator, further enhanced O2- production and translocation of the cytosolic activation factors.	Oxygen	97-99	Prkca	Cavia porcellus	65-68
7998927-2	1994	We have demonstrated three actions of DTT on tyrosinase-catalysed reactions: (1) direct reduction of the copper at the active site of the enzyme; (2) generation of secondary, oxidizable species by adduct formation with the o-quinone reaction product, 4-MOB, which leads to an increase in the total oxygen utilization by the reaction system; and (3) reversible inhibition of the enzyme.	Oxygen	298-304	tyrosinase	Homo sapiens	45-55
7957077-6	1994	These data reveal a role for the Mpv17 protein in peroxisomal reactive oxygen metabolism and establish a novel link between peroxisomal ROS production and glomerulosclerosis.	Oxygen	71-77	MpV17 mitochondrial inner membrane protein	Mus musculus	33-38
8914593-6	1996	Compared with Percoll isolated eosinophils, anti-CD16 bead separated eosinophils had significantly increased baseline and stimulated LTC4 production, spontaneous O2- generation, and expression of specific cell surface markers.	Oxygen	162-164	Fc gamma receptor IIIa	Homo sapiens	49-53
8798700-0	1996	Characterization of an upstream activation sequence and two Rox1p-responsive sites controlling the induction of the yeast HEM13 gene by oxygen and heme deficiency.	Oxygen	136-142	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	122-127
8798700-1	1996	The Saccharomyces cerevisiae HEM13 gene codes for coproporphyrinogen oxidase, an oxygen-requiring enzyme catalyzing the sixth step of heme biosynthesis.	Oxygen	81-87	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	29-34
8798700-1	1996	The Saccharomyces cerevisiae HEM13 gene codes for coproporphyrinogen oxidase, an oxygen-requiring enzyme catalyzing the sixth step of heme biosynthesis.	Oxygen	81-87	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	50-76
3366737-4	1988	Vimentin filament staining of O2-exposed monolayers showed thickening of the perinuclear vimentin coil in some cells.	Oxygen	30-32	vimentin	Bos taurus	0-8
8798700-7	1996	HEM13 UAS conferred a 2-4-fold oxygen/heme control on a heterologous reporter gene.	Oxygen	31-37	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	0-5
7847820-2	1994	The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase and macrophage/phorbol myristate acetate reaction systems.	Oxygen	105-107	xanthine dehydrogenase	Mus musculus	132-148
7882162-1	1994	The elastin-laminin receptor was shown to be present on several benign and malignant cell types and to mediate several important cell reactions such as chemotactic movements of fibroblasts and monocytes, release of lytic enzymes and oxygen free radicals from leucocytes, increased adhesion of mesenchymal cells to elastin fibers as well as modifications of ion fluxes-increase of calcium and sodium influxes and decrease of ouabain-dependent potassium influx.	Oxygen	233-239	elastin	Rattus norvegicus	4-11
3366737-4	1988	Vimentin filament staining of O2-exposed monolayers showed thickening of the perinuclear vimentin coil in some cells.	Oxygen	30-32	vimentin	Bos taurus	89-97
8840857-3	1996	METHODS AND RESULTS: With the use of human umbilical vein endothelial cells and transfected porcine aortic endothelial cells, KDR protein was found to be upregulated under hypoxic conditions (2% O2) in both cell types.	Oxygen	195-197	kinase insert domain receptor	Homo sapiens	126-129
3365329-1	1988	Arachidonate 5-lipoxygenase of a 10,000 x g supernatant from RBL-1 cell homogenate was studied by a continuous assay measuring enzyme-catalysed oxygen consumption.	Oxygen	18-24	RB transcriptional corepressor like 1	Rattus norvegicus	61-66
8921438-5	1996	N-acetylcysteine inhibited this effect, indicating that reactive oxygen intermediates are required for RANTES production.	Oxygen	65-71	C-C motif chemokine ligand 5	Homo sapiens	103-109
8064127-8	1994	However, at 50 hr after O2 exposure the intensity of pulmonary MnSOD was reduced.	Oxygen	24-26	superoxide dismutase 2	Rattus norvegicus	63-68
8064127-9	1994	In contrast, tracheal insufflation of IL-1 markedly enhanced the intensity of pulmonary MnSOD in rats exposed to O2 for 50 hr.	Oxygen	113-115	superoxide dismutase 2	Rattus norvegicus	88-93
8964081-3	1996	On the other hand, N6,O2-dibutyryl cAMP enhanced the production of IL-10 but not IFN-gamma when the low doses of Con A or A23187 coexisted.	Oxygen	22-24	interleukin 10	Homo sapiens	67-72
3278899-1	1988	The redox and acid/base states and midpoint potentials of cytochrome b-559 have been determined in oxygen-evolving photosystem II (PS II) particles at room temperature in the pH range from 6.5 to 8.5.	Oxygen	99-105	mitochondrially encoded cytochrome b	Homo sapiens	58-70
8873995-13	1996	In the minor groove the cytosine carbonyl oxygen atoms of the GpC and CpG steps are cross-bridged by water molecules that are not themselves hydrogen bonded but are enclosed by the water rings in the mouth of the minor groove.	Oxygen	42-48	glycophorin C (Gerbich blood group)	Homo sapiens	62-65
8035787-4	1994	A superinduction of c-jun message resulted during simultaneous oxygen and glucose deprivation, with several characteristics of an induction mediated by oxidative-stress pathways.	Oxygen	63-69	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
8048968-3	1994	The aim of the present study was to investigate the relationship between methemoglobin (metHb)-induced lipid peroxidation, rose bengal luminescence, and O2 consumption in a system containing 0-850 mu M phospholipid and 1 mu M metHb and 1 mu M rose bengal in Tris-HCl buffer, pH 7.4.	Oxygen	153-155	hemoglobin subunit gamma 2	Homo sapiens	73-86
11538460-4	1988	They indicate that resonance excitation of the broad isotopic bands of molecules such as 12C16O, MgO, O2, AlO, and OH by strong UV line sources such as H-L alpha, Mg II, H beta, and Ca II may induce selective reactions resulting in the anomalous isotopic composition of oxygen and possibly other elements in refractory oxide condensates in meteorites.	Oxygen	102-104	carbonic anhydrase 2	Homo sapiens	152-187
8192151-1	1994	Inherited protein S deficiency and the presence of a rare high oxygen affinity hemoglobin variant: Hb Rainier [beta 145 (HC2) Tyr--&gt;Cys] were found in a family.	Oxygen	63-69	CYCS pseudogene 38	Homo sapiens	121-124
8694255-4	1996	Phenol is oxidized in the sensor membrane by the oxygen-consuming tyrosinase via catechol to o-quinone.	Oxygen	49-55	tyrosinase	Homo sapiens	66-76
11538460-4	1988	They indicate that resonance excitation of the broad isotopic bands of molecules such as 12C16O, MgO, O2, AlO, and OH by strong UV line sources such as H-L alpha, Mg II, H beta, and Ca II may induce selective reactions resulting in the anomalous isotopic composition of oxygen and possibly other elements in refractory oxide condensates in meteorites.	Oxygen	270-276	carbonic anhydrase 2	Homo sapiens	152-187
3122744-0	1987	c-fos expression in human skin fibroblasts by reperfusion after oxygen deficiency: a recovery change of human skin fibroblasts after oxygen deficiency stress.	Oxygen	64-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8760382-16	1996	From these results we conclude that the T3-mediated transcriptional induction leading to increased activity of ANT2 and mGPDH contributes considerably to the increase in mitochondrial oxygen consumption in rat tissues.	Oxygen	184-190	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	120-125
8897649-2	1996	Breathing a gas mixture with elevated CO2 (15% CO2, 21% O2 and 64% N2, or 15% CO2 balance O2) for 60 min, induced activation of the c-fos gene in widespread regions of the CNS, as indicated by the expression of Fos-like immunoreactive protein (Fos).	Oxygen	39-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
8897649-2	1996	Breathing a gas mixture with elevated CO2 (15% CO2, 21% O2 and 64% N2, or 15% CO2 balance O2) for 60 min, induced activation of the c-fos gene in widespread regions of the CNS, as indicated by the expression of Fos-like immunoreactive protein (Fos).	Oxygen	48-50	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
8831970-0	1996	On the nature of the irreversible inhibition of histidine ammonia lyase by cysteine and dioxygen.	Oxygen	88-96	histidine ammonia-lyase	Homo sapiens	48-71
8831970-1	1996	The irreversible inhibition of histidine ammonia lyase by L-cysteine and dioxygen has been reexamined.	Oxygen	73-81	histidine ammonia-lyase	Homo sapiens	31-54
7944270-6	1994	Supernatant K+ and hemoglobin increased in the IRR + O2 group over IRR and Control, +O2 did not rise compared to Control.	Oxygen	53-55	insulin receptor related receptor	Homo sapiens	47-50
8006968-0	1994	Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn--&gt;Lys) that can modulate cooperativity as well as oxygen affinity.	Oxygen	143-149	sodium voltage-gated channel alpha subunit 2	Homo sapiens	55-59
8200984-7	1994	In air-breathing rats, the pertussis toxin-induced decrease in MnSOD activity was associated with the development of lung edema, pleural effusion with a high concentration of protein, and biochemical evidence of lung oxygen toxicity.	Oxygen	217-223	superoxide dismutase 2	Rattus norvegicus	63-68
3122744-0	1987	c-fos expression in human skin fibroblasts by reperfusion after oxygen deficiency: a recovery change of human skin fibroblasts after oxygen deficiency stress.	Oxygen	133-139	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8158148-4	1994	Incubation of MBzTP with purified MAO B yields first the dihydropyridinium form, then a mixture of the pyridinium form and another unidentified product, in proportions that depend on the concentrations of MAO B and oxygen.	Oxygen	215-221	monoamine oxidase B	Homo sapiens	34-39
8763840-1	1996	The group I aziridinylquinone anti-cancer agents mitomycin C, diaziquone or trenimon were much more cytotoxic to DT-diaphorase-enriched L5178Y/HBM10 lymphoblasts than parental L5178Y cells and caused little oxygen activation.	Oxygen	207-213	NAD(P)H dehydrogenase, quinone 1	Mus musculus	113-126
3122744-1	1987	A dramatic and specific induction of c-fos mRNA was observed in human skin fibroblasts in vitro culture by oxygen reperfusion after oxygen deficiency treatment.	Oxygen	107-113	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
8763840-5	1996	Inactivation of DT-diaphorase, however, prevented both oxygen activation and cytotoxicity.	Oxygen	55-61	NAD(P)H dehydrogenase, quinone 1	Mus musculus	16-29
3122744-1	1987	A dramatic and specific induction of c-fos mRNA was observed in human skin fibroblasts in vitro culture by oxygen reperfusion after oxygen deficiency treatment.	Oxygen	132-138	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
8159712-1	1994	Peroxisomal acyl-CoA oxidase (ACOX; EC 1.3.3.6) is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs, and it donates electrons directly to molecular oxygen, thereby producing H2O2.	Oxygen	226-232	acyl-CoA oxidase 1	Homo sapiens	12-28
3122744-2	1987	C-fos mRNA reached a maximum about 30-60 min after oxygen reperfusion and declined to basal level after 120 min.	Oxygen	51-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8159712-1	1994	Peroxisomal acyl-CoA oxidase (ACOX; EC 1.3.3.6) is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs, and it donates electrons directly to molecular oxygen, thereby producing H2O2.	Oxygen	226-232	acyl-CoA oxidase 1	Homo sapiens	30-34
3122744-4	1987	More long duration of oxygen deficiency induced a decreasing tendency of c-fos mRNA overexpression due to essential and irreversible cellular damage.	Oxygen	22-28	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
8710512-3	1996	The multiple interactions of nuclear proteins with the UAS region of CYT1 observed in electrophoretic mobility shift experiments are influenced by carbon source and oxygen tension, but are independent of both regulators, Hap1p and Hap2/3/4/5.	Oxygen	165-171	ubiquinol--cytochrome-c reductase catalytic subunit CYT1	Saccharomyces cerevisiae S288C	69-73
3122744-5	1987	Thus increased c-fos gene expression might be an early event in cellular recovery process in particularly human skin fibroblasts with oxygen deficiency.	Oxygen	134-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20
3480708-2	1987	Data from several models of acute pancreatitis suggest that the in vivo conversion of the enzyme xanthine dehydrogenase to xanthine oxidase may cause tissue damage by the subsequent generation of oxygen-derived free radical products.	Oxygen	196-202	xanthine dehydrogenase	Mus musculus	97-119
11667282-6	1996	Thermolysis or photolysis of 8e or9b led via electrocyclic ring opening to a vinyl ketene which was trapped by MeOH, alkenes, dienes, or oxygen to produce polyfunctional unsaturated esters 29 and 30 or 8-membered ring lactone 31, fused cyclobutanones 33 and 34, pyranone 38, or gamma-lactone 39, respectively.	Oxygen	137-143	olfactory receptor family 1 subfamily B member 1	Homo sapiens	32-36
8082171-4	1994	The level of CYT2 mRNA is not influenced by the presence or absence of oxygen or of heme, but it is subject to carbon-source control.	Oxygen	71-77	cytochrome c1 heme lyase CYT2	Saccharomyces cerevisiae S288C	13-17
8145074-0	1994	Corticotropin-releasing hormone decreases feeding, oxygen consumption and activity of genetically obese (ob/ob) and lean mice.	Oxygen	51-57	corticotropin releasing hormone	Mus musculus	0-31
3480708-2	1987	Data from several models of acute pancreatitis suggest that the in vivo conversion of the enzyme xanthine dehydrogenase to xanthine oxidase may cause tissue damage by the subsequent generation of oxygen-derived free radical products.	Oxygen	196-202	xanthine dehydrogenase	Mus musculus	123-139
8641834-12	1996	Specific VEGF binding to BREC was decreased from 15.1% +/- 0.3% to 12.7% +/- 0.4% per milligram protein (P &lt; 0.001) after exposure to 1% oxygen for 24 hours.	Oxygen	140-146	vascular endothelial growth factor A	Bos taurus	9-13
3666141-0	1987	Hemoglobin Grange-Blanche [beta 27(B9) Ala----Val], a new variant with normal expression and increased affinity for oxygen.	Oxygen	116-122	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	0-37
8641834-13	1996	In contrast, long-term exposure to 1% oxygen (72 hours) resulted in an increase of VEGF binding from 13.5% +/- 1.1% to 18.3% +/- 0.8% per milligram protein (P &lt; 0.001).	Oxygen	38-44	vascular endothelial growth factor A	Bos taurus	83-87
8610133-7	1996	Compared with the normoxic controls, we found increased aldolase A and VEGF mRNA levels after exposing 8- to 9-day-old EBs to 1% oxygen.	Oxygen	129-135	vascular endothelial growth factor A	Mus musculus	71-75
8145074-4	1994	Corticotropin-releasing hormone also lowered the oxygen consumption of ob/ob and lean mice, without affecting brown adipose tissue metabolism as assessed by measurement of GDP binding to brown adipose tissue mitochondria.	Oxygen	49-55	corticotropin releasing hormone	Mus musculus	0-31
8145074-6	1994	The CRH-induced lowering of oxygen consumption and grooming activity in mice contrasts with CRH-induced elevations of oxygen consumption and grooming in rats, suggesting species-specific responses to this peptide.	Oxygen	28-34	corticotropin releasing hormone	Mus musculus	4-7
8145074-6	1994	The CRH-induced lowering of oxygen consumption and grooming activity in mice contrasts with CRH-induced elevations of oxygen consumption and grooming in rats, suggesting species-specific responses to this peptide.	Oxygen	118-124	corticotropin releasing hormone	Mus musculus	92-95
8189642-2	1994	Pulmonary vascular response to oxygen was evaluated by the percent change in pulmonary arteriolar resistance after 100% oxygen inhalation (% delta PAR), and its relation to the pressure-flow relationship during incremental exercise was assessed.	Oxygen	31-37	jumping translocation breakpoint	Homo sapiens	147-150
8297392-4	1994	The involvement of cytochrome P450 is demonstrated by the dependence of hydroxylation upon O2 and NADPH, and by their light-reversible inhibition by carbon monoxide.	Oxygen	91-93	cytochrome P450 709B1	Triticum aestivum	19-34
7506737-9	1994	Therefore, in neutrophil-dependent and oxygen radical mediated lung injury, L-selectin plays a requisite role in tissue recruitment of neutrophils.	Oxygen	39-45	selectin L	Rattus norvegicus	76-86
8928810-7	1996	Western analysis using an antibody specific to rat heme oxygenase 1 verified that this oxygen-responsive protein is heme oxygenase 1.	Oxygen	56-62	heme oxygenase 1	Rattus norvegicus	116-132
8735843-6	1996	Replacement of the alpha, beta-bridging oxygen in dUTP with an imido group resulted in a nonhydrolyzable substrate analogue and a potent competitive inhibitor of dUTPase (Ki = 5 microM).	Oxygen	40-46	Deoxyuridine triphosphatase	Drosophila melanogaster	162-169
3115772-4	1987	In the presence of oxygen, the speed of methemoglobin formation was three to four times faster in the hemolyzed and plasma-free samples than in whole blood.	Oxygen	19-25	hemoglobin subunit gamma 2	Homo sapiens	40-53
8635221-6	1996	After hemoglobin was incubated in human plasma, its oxygen-binding parameters, the P50, and the Hill coefficient decreased drastically due to cleavage by CPN.	Oxygen	52-58	carboxypeptidase N subunit 1	Homo sapiens	154-157
8598553-7	1996	4, when rats were exposed to 7.6 O2 hypoxia after 4 hr of eating the HP diet, the plasma gastrin concentration in the 7.6% O2 hypoxic rats was 2.3-fold that of the normoxic rats after 6 h of hypoxia.	Oxygen	33-35	gastrin	Rattus norvegicus	89-96
8305467-14	1994	Experiments on retinoic acid formation under 18O2 or H2(18)O demonstrated that the oxygen of water was incorporated into retinoic acid by the retinal oxidase, but not molecular oxygen.	Oxygen	83-89	aldehyde oxidase 1	Oryctolagus cuniculus	142-157
8598553-8	1996	Furthermore, when rats that did not consume any HP diet on the day of the experiment were exposed to 7.6 or 10.5% O2 hypoxia, the plasma gastrin concentration was higher in both hypoxic groups than in the normoxic group after 3 and 6 of hypoxia.	Oxygen	114-116	gastrin	Rattus norvegicus	137-144
2823975-2	1987	A concentration-dependent stimulation of central pro-opiomelanocortin neuropeptides was demonstrated after exposures to variable concentrations of nitrous oxide with oxygen.	Oxygen	166-172	proopiomelanocortin	Rattus norvegicus	49-69
8630268-3	1996	Our previous in situ hybridization studies indicated that exposure of pups to &gt; 95% oxygen from 3 to 13 days of age interfered with the increased in TE gene expression in interstitial fibroblasts normally seen during septation.	Oxygen	87-93	elastin	Rattus norvegicus	152-154
7512397-0	1994	RANTES augments radical oxygen products from eosinophils.	Oxygen	24-30	C-C motif chemokine ligand 5	Homo sapiens	0-6
7512397-2	1994	Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils.	Oxygen	65-71	C-C motif chemokine ligand 5	Homo sapiens	47-53
8265658-8	1993	Analysis of light-response curves for oxygen evolution for the mutants R2S2C3 and R2K1 revealed that cells with photosystem II reaction centers containing D1:2 have a higher apparent quantum yield (approximately 25%) than cells possessing D1:1.	Oxygen	38-44	unconventional SNARE in the ER 1	Homo sapiens	155-159
3040731-2	1987	Soybean lipoxygenase is a non-heme iron enzyme that catalyzes the hydroperoxidation of linoleic acid by dioxygen.	Oxygen	104-112	linoleate 9S-lipoxygenase-4	Glycine max	8-20
8267656-10	1993	It is likely that an active Fe2(+)-oxygen complex, formed via NADPH-cytochrome P450 reductase and cytochrome P450-dependent reduction of free Fe3+ followed by oxygen binding, serves as the species inducing lipid peroxidation and at least part of (S)-4-OH-OTA formation.	Oxygen	35-41	cytochrome p450 oxidoreductase	Rattus norvegicus	62-93
8267656-10	1993	It is likely that an active Fe2(+)-oxygen complex, formed via NADPH-cytochrome P450 reductase and cytochrome P450-dependent reduction of free Fe3+ followed by oxygen binding, serves as the species inducing lipid peroxidation and at least part of (S)-4-OH-OTA formation.	Oxygen	159-165	cytochrome p450 oxidoreductase	Rattus norvegicus	62-93
8779917-4	1996	The functional expression of CFTR by the stable transfection of mouse mammary carcinoma cells, C1271, with human epithelial CFTR cDNA resulted in a stimulated metabolism, since both basal and cAMP-inducible O2 consumption were increased compared with mock-transfected cells.	Oxygen	207-209	cystic fibrosis transmembrane conductance regulator	Mus musculus	29-33
20650183-1	1996	Phenoxyl radicals are inevitable intermediates in the oxidative enzymatic metabolism of a phenolic antitumour drug, etoposide (VP-16), by peroxidases, cytochrome P-450, prostaglandin synthetase and tyrosinase, as well as in its interactions with oxygen and peroxyl radicals.	Oxygen	246-252	host cell factor C1	Homo sapiens	127-132
3318547-7	1987	Methemoglobin and carbon monoxide shift the oxygen dissociation curve to the left, so that intoxication with both substances reduces both total oxygen capacity and oxygen delivery of the remaining hemoglobin able to bind oxygen.	Oxygen	44-50	hemoglobin subunit gamma 2	Homo sapiens	0-13
8579585-2	1996	Oxygen affinity was significantly decreased in blood containing NO-bound Hb alpha.	Oxygen	0-6	sodium voltage-gated channel alpha subunit 2	Homo sapiens	73-81
8112568-0	1993	Genetic and biochemical analysis of glutathione-S-transferase in the oxygen defense system of Drosophila melanogaster.	Oxygen	69-75	Glutathione S transferase S1	Drosophila melanogaster	36-61
8309962-2	1993	Acute exercise equivalent to 80% VO2-max (maximal oxygen consumption) transiently increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues.	Oxygen	50-56	butyrylcholinesterase	Rattus norvegicus	100-103
3318547-7	1987	Methemoglobin and carbon monoxide shift the oxygen dissociation curve to the left, so that intoxication with both substances reduces both total oxygen capacity and oxygen delivery of the remaining hemoglobin able to bind oxygen.	Oxygen	144-150	hemoglobin subunit gamma 2	Homo sapiens	0-13
8246899-5	1993	A defect in mitochondrial function may be the cause of the petite phenotype: the rate of oxygen consumption by intact gef2 cells and by mitochondrial fractions isolated from gef2 mutants was reduced 60%-75% relative to wild type.	Oxygen	89-95	H(+)-transporting V0 sector ATPase subunit c	Saccharomyces cerevisiae S288C	118-122
3318547-7	1987	Methemoglobin and carbon monoxide shift the oxygen dissociation curve to the left, so that intoxication with both substances reduces both total oxygen capacity and oxygen delivery of the remaining hemoglobin able to bind oxygen.	Oxygen	144-150	hemoglobin subunit gamma 2	Homo sapiens	0-13
8246899-5	1993	A defect in mitochondrial function may be the cause of the petite phenotype: the rate of oxygen consumption by intact gef2 cells and by mitochondrial fractions isolated from gef2 mutants was reduced 60%-75% relative to wild type.	Oxygen	89-95	H(+)-transporting V0 sector ATPase subunit c	Saccharomyces cerevisiae S288C	174-178
8730798-4	1996	Only 12% of astrocytes expressing HSP-70 died after 7 hours of oxygen-glucose deprivation compared to 65% of astrocytes expressing beta-galactosidase and 82% of normal astrocytes.	Oxygen	63-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-40
3318547-7	1987	Methemoglobin and carbon monoxide shift the oxygen dissociation curve to the left, so that intoxication with both substances reduces both total oxygen capacity and oxygen delivery of the remaining hemoglobin able to bind oxygen.	Oxygen	144-150	hemoglobin subunit gamma 2	Homo sapiens	0-13
8555214-12	1996	This is consistent with earlier proposals that Fe alpha 3 and Cu(B) are acting together as a two-electron donor to dioxygen.	Oxygen	115-123	FEA	Homo sapiens	47-55
8573091-6	1996	In this study, to elucidate the mechanism for the inhibition, the effect of spermine on cell-free activation of the O2- generating enzyme (NADPH oxidase) was examined.	Oxygen	116-118	2,4-dienoyl-CoA reductase 1	Homo sapiens	139-144
8226746-13	1993	These results suggest that the alpha-meso-hydroxylation required for biliverdin formation is mediated by the distal of the two oxygens in the iron-dioxygen intermediate (Fe-O-O) engendered by reaction with either cytochrome P450 reductase/NADPH or H2O2.	Oxygen	127-134	cytochrome p450 oxidoreductase	Rattus norvegicus	213-238
8373414-0	1993	A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures.	Oxygen	28-34	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	99-132
8373414-1	1993	Oxygen modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene.	Oxygen	0-6	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	58-91
8373414-1	1993	Oxygen modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene.	Oxygen	0-6	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	93-96
8530368-6	1995	Unsaturated fatty acids in yeast are formed by Ole1p, an oxygen-dependent delta-9 fatty acid desaturase that is an intrinsic endoplasmic reticulum membrane protein.	Oxygen	57-63	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	47-52
8373414-6	1993	PCK mRNA and PCK activity were elevated after 2h and 3h, respectively, to 100% at 16% O2 (mimicking arterial oxygen tensions) and to about 60% at 8% O2 (mimicking venous oxygen tensions).	Oxygen	86-88	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
3115178-3	1987	The ability of the chicken erythrocyte to accumulate 2,3-bisphosphoglycerate (2,3-P2-glycerate) and its effect upon the oxygen affinity (P50) of the cell suspensions have been determined.	Oxygen	120-126	dynactin subunit 2	Gallus gallus	137-140
8373414-6	1993	PCK mRNA and PCK activity were elevated after 2h and 3h, respectively, to 100% at 16% O2 (mimicking arterial oxygen tensions) and to about 60% at 8% O2 (mimicking venous oxygen tensions).	Oxygen	86-88	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	13-16
8373414-6	1993	PCK mRNA and PCK activity were elevated after 2h and 3h, respectively, to 100% at 16% O2 (mimicking arterial oxygen tensions) and to about 60% at 8% O2 (mimicking venous oxygen tensions).	Oxygen	109-115	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
8373414-6	1993	PCK mRNA and PCK activity were elevated after 2h and 3h, respectively, to 100% at 16% O2 (mimicking arterial oxygen tensions) and to about 60% at 8% O2 (mimicking venous oxygen tensions).	Oxygen	149-151	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
8373414-6	1993	PCK mRNA and PCK activity were elevated after 2h and 3h, respectively, to 100% at 16% O2 (mimicking arterial oxygen tensions) and to about 60% at 8% O2 (mimicking venous oxygen tensions).	Oxygen	170-176	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
8373414-7	1993	CO counteracted the reduced induction at lower oxygen tensions: Under 8% O2 + 2% CO PCK mRNA could be elevated again to about 90% and PCK activity to about 80%.	Oxygen	47-53	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	84-87
8373414-7	1993	CO counteracted the reduced induction at lower oxygen tensions: Under 8% O2 + 2% CO PCK mRNA could be elevated again to about 90% and PCK activity to about 80%.	Oxygen	73-75	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	84-87
8373414-7	1993	CO counteracted the reduced induction at lower oxygen tensions: Under 8% O2 + 2% CO PCK mRNA could be elevated again to about 90% and PCK activity to about 80%.	Oxygen	73-75	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	134-137
8541312-8	1995	Fe(II)NTA inactivated G-6-PD and GSSGRase in a O2-dependent manner, however, G-6-PD was more susceptible to the damage.	Oxygen	47-49	glucose-6-phosphate dehydrogenase	Homo sapiens	22-28
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	294-300	glutamate-ammonia ligase	Rattus norvegicus	217-237
8821124-4	1995	The ratio of the two rates, d[conjugated diene/-d[O2], is 2/1 for the prostaglandin endoperoxide synthase catalyzed reaction and 1/1 for the lipoxygenase reaction.	Oxygen	50-52	linoleate 9S-lipoxygenase-4	Glycine max	141-153
8593679-0	1995	Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae.	Oxygen	83-89	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	97-102
8373414-11	1993	These results are in line with the proposal that a ferro-heme protein rather than the respiratory chain acted as an O2 sensor in the activation of the PCK gene.	Oxygen	116-118	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	151-154
8214089-3	1993	Results of in situ hybridizations indicated a delay in peak tropoelastin (TE) message levels in oxygen-exposed rats vs. controls, day 16 vs. day 11, respectively.	Oxygen	96-102	elastin	Rattus norvegicus	60-72
8593679-0	1995	Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae.	Oxygen	83-89	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	109-135
8593679-1	1995	The Saccharomyces cerevisiae HEM13 gene codes for coproporphyrinogen oxidase (CPO), an oxygen-requiring enzyme catalysing the sixth step of heme biosynthesis.	Oxygen	87-93	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	29-34
8214089-3	1993	Results of in situ hybridizations indicated a delay in peak tropoelastin (TE) message levels in oxygen-exposed rats vs. controls, day 16 vs. day 11, respectively.	Oxygen	96-102	elastin	Rattus norvegicus	74-76
2886388-2	1987	In these studies the levels of DNPH-reactive proteins increased steadily during 48 h of continuous oxygen treatment and then decreased to control levels by 54 h. Although the specific activity of two hepatic enzymes, glutamine synthetase and glucose-6-phosphate dehydrogenase, decreased during oxygen treatment, antibody titration of each enzyme indicated that the levels of immunological cross-reactive protein either remained constant or increased slightly during 48 h of oxygen treatment.	Oxygen	294-300	glutamate-ammonia ligase	Rattus norvegicus	217-237
8214089-4	1993	In addition, lung parenchymal TE mRNA levels in the oxygen-exposed pups remained elevated through day 23, 1 wk after TE mRNA levels had decreased in controls.	Oxygen	52-58	elastin	Rattus norvegicus	30-32
8214089-4	1993	In addition, lung parenchymal TE mRNA levels in the oxygen-exposed pups remained elevated through day 23, 1 wk after TE mRNA levels had decreased in controls.	Oxygen	52-58	elastin	Rattus norvegicus	117-119
8593679-1	1995	The Saccharomyces cerevisiae HEM13 gene codes for coproporphyrinogen oxidase (CPO), an oxygen-requiring enzyme catalysing the sixth step of heme biosynthesis.	Oxygen	87-93	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	50-76
8593679-12	1995	Taken together, these results suggest that induction of HEM13 occurs in part through relief of repression exerted by Rox1p and Cyp1p, and in part by activation mediated partly by Cyp1p under heme-deficiency and by unknown factors under oxygen-deficiency.	Oxygen	236-242	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	56-61
8544418-11	1995	Oxygen metabolites have been shown to induce EC expression of ICAM 1.	Oxygen	0-6	intercellular adhesion molecule 1	Rattus norvegicus	62-68
8363114-8	1993	The total oxygen-carrying capacity reduced by the combination of carboxyhemoglobin and methemoglobin was never more than 21% (range, 10% to 21%) in this series.	Oxygen	10-16	hemoglobin subunit gamma 2	Homo sapiens	87-100
3626595-4	1987	GAA could induce the formation of O2 and H2O2 and could inhibit Ca2+ sequestration in rat liver microsomes in vitro.	Oxygen	34-36	alpha glucosidase	Rattus norvegicus	0-3
10055419-0	1993	Spin-orbit levels resolved in the decay of O2 by autoionization.	Oxygen	43-45	spindlin 1	Homo sapiens	0-4
10055435-0	1993	Oxygen adsorption on Co(101-bar0): Different reconstruction behavior of hcp (101-bar0) and fcc(110).	Oxygen	0-6	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	72-75
7577912-1	1995	The active site of pig heart citrate synthase contains a histidine residue (H320) which interacts with the carbonyl oxygen of oxaloacetate and is implicated in substrate activation through carbonyl bond polarization, a major catalytic strategy of the enzyme.	Oxygen	116-122	citrate synthase	Sus scrofa	29-45
7546767-0	1995	Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury.	Oxygen	100-106	vascular endothelial growth factor A	Oryctolagus cuniculus	0-34
3571976-7	1987	These results show that oxygen metabolites are important for the killing of schistosomula by lowering the concentration of ECP needed to inflict damage.	Oxygen	24-30	ribonuclease A family member 3	Homo sapiens	123-126
2822166-3	1987	Photochemical action spectra for the relief of CO-inhibited O2 uptake revealed contributions from both cytochrome b-245 and myeloperoxidase.	Oxygen	60-62	cytochrome b, mitochondrial	Rattus norvegicus	103-115
3576843-5	1987	Breathing air or He-O2 postdive did not alter these responses, but He-O2 breathing produced an 11% increase in pulmonary vascular resistance (PVR).	Oxygen	70-72	PVR cell adhesion molecule	Canis lupus familiaris	142-145
3813207-1	1987	We studied damage and repair of lung connective tissue in rats exposed to toxic amounts of oxygen by measuring lung content of collagen and elastin and the number of collagen fragments in lung lavage fluid after exposure to 98% O2 for 60 h. Lung collagen was decreased 17%, and collagen fragments in lavage fluid were increased 4- to 5-fold in O2-exposed rats compared with those in control rats.	Oxygen	91-97	elastin	Rattus norvegicus	140-147
2959265-6	1987	In contrast myocardial oxygen consumption per beat was reduced by only 18%, from 138 +/- 28 to 113 +/- 17 microliters O2/100 g (p less than 0.01).	Oxygen	23-29	immunoglobulin kappa variable 1D-39	Homo sapiens	118-126
2462531-4	1987	This indicates that a nuclear NADPH-enzyme, presumably NADPH-cytochrome P-450 reductase, is able to redox cycle a bleomycin-iron-complex which in the reduced form can activate oxygen to a DNA-damaging reactive species.	Oxygen	176-182	cytochrome p450 oxidoreductase	Rattus norvegicus	55-87
3508430-3	1987	Addition of superoxide dismutase or catalase clearly suppressed the ethanol-induced release of GPT and SDH, suggesting that .O2- and H2O2 are involved in this process.	Oxygen	125-127	glutamic--pyruvic transaminase	Rattus norvegicus	95-98
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Oxygen	115-121	catalase	Gallus gallus	43-51
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Oxygen	115-121	catalase	Gallus gallus	169-177
3503486-4	1987	Since presently the only known function of catalase is the enzymatic degradation of hydrogen peroxide to water and oxygen, the simplest interpretation of the ability of catalase to support neuronal survival would be that catalase removes from the culture medium hydrogen peroxide.	Oxygen	115-121	catalase	Gallus gallus	169-177
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	Oxygen	75-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
2429100-14	1986	In vitro studies indicated that MPG effectively scavanges O2- generated by the hypoxanthine-xanthine oxidase reaction, as well as by PMA-activated polymorphonuclear leukocytes.	Oxygen	58-60	N-methylpurine DNA glycosylase	Canis lupus familiaris	32-35
3018559-11	1986	ACP1 and ten other phosphatases were tested for their ability to dephosphorylate proteins and to inhibit O2- production by stimulated human neutrophils.	Oxygen	105-107	acid phosphatase 1	Homo sapiens	0-4
3018559-13	1986	The results indicate that ACP1 probably blocks the production of reduced oxygen intermediates by a mechanism that does not involve dephosphorylation of phosphoproteins; however, the possibility that the parasite"s phosphatase affects phagocyte metabolism by degrading PIP2 or IP3 should be considered.	Oxygen	73-79	acid phosphatase 1	Homo sapiens	26-30
3533184-2	1986	This study confirmed the efficacy of nasal CPAP on sleep parameters: total sleep time was increased; light non-REM sleep was diminished; slow-wave sleep and REM sleep were augmented; sleep apnoeas were eliminated completely or almost completely; oxygen saturation was markedly improved.	Oxygen	246-252	centromere protein J	Homo sapiens	43-47
3744926-2	1986	The yield of radiolytic oxygen depletion, g(-O2), in alpha medium was determined to be about 0.44 microM/Gy (equivalent to 3.6 ppm/rad) over a range of oxygen from about 1,000 to 209,000 ppm.	Oxygen	24-30	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	13-16
3744926-2	1986	The yield of radiolytic oxygen depletion, g(-O2), in alpha medium was determined to be about 0.44 microM/Gy (equivalent to 3.6 ppm/rad) over a range of oxygen from about 1,000 to 209,000 ppm.	Oxygen	152-158	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	13-16
3018103-2	1986	The ability of different IFN species to induce xanthine oxidase correlated with their ability to depress liver cytochrome P-450-dependent drug metabolism, supporting the hypothesis that reactive oxygen metabolites generated by xanthine oxidase might be responsible for this impairment of liver function by IFN.	Oxygen	195-201	xanthine dehydrogenase	Mus musculus	47-63
3018103-2	1986	The ability of different IFN species to induce xanthine oxidase correlated with their ability to depress liver cytochrome P-450-dependent drug metabolism, supporting the hypothesis that reactive oxygen metabolites generated by xanthine oxidase might be responsible for this impairment of liver function by IFN.	Oxygen	195-201	xanthine dehydrogenase	Mus musculus	227-243
3699149-3	1986	The results reinforce the belief that cytochrome b-245 is a major component of the NADPH oxidase and plays a fundamental role in the formation of O2-by neutrophils.	Oxygen	146-148	mitochondrially encoded cytochrome b	Homo sapiens	38-50
3524305-3	1986	Important events were the first demonstration of Koller"s local anaesthesia in the eye in 1884, the first intubation for anaesthesia in Heidelberg, performed by F. Kuhn of Kassel and the development by M. Neu of a rotameter apparatus for nitrous oxide/oxygen anaesthesia in 1910.	Oxygen	252-258	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	205-208
3948176-8	1986	Ornithine decarboxylase, on the other hand, was increased as long as the animals remained exposed to oxygen.	Oxygen	101-107	ornithine decarboxylase, structural 1	Mus musculus	0-23
8567556-1	1995	Although the consumption of myoglobin-bound O2 (MbO2) stores in seal muscles has been demonstrated in seal muscles during laboratory simulations of diving, this may not be a feature of normal field diving in which measurements of heart rate and lactate production show marked differences from the profound diving response induced by forced immersion.	Oxygen	44-46	myoglobin	Leptonychotes weddellii	28-37
8567556-6	1995	Two seals had occasional partial muscle resaturations late in dives, indicating transfer of O2 from circulating blood to muscle myoglobin.	Oxygen	92-94	myoglobin	Leptonychotes weddellii	128-137
8709854-15	1995	To simultaneously allow for oxygen-evolving photosynthesis and oxygen-sensitive nitrogen fixation, the Nif1-type system probably branched from an ancestral Nif2-type system and has evolved for an exclusive operation within heterocysts.	Oxygen	28-34	zinc finger protein 335	Homo sapiens	103-107
8709854-15	1995	To simultaneously allow for oxygen-evolving photosynthesis and oxygen-sensitive nitrogen fixation, the Nif1-type system probably branched from an ancestral Nif2-type system and has evolved for an exclusive operation within heterocysts.	Oxygen	28-34	zinc finger protein 335	Homo sapiens	156-160
8709854-15	1995	To simultaneously allow for oxygen-evolving photosynthesis and oxygen-sensitive nitrogen fixation, the Nif1-type system probably branched from an ancestral Nif2-type system and has evolved for an exclusive operation within heterocysts.	Oxygen	63-69	zinc finger protein 335	Homo sapiens	103-107
8405659-2	1993	The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium.	Oxygen	61-63	tyrosinase	Homo sapiens	77-87
8709854-15	1995	To simultaneously allow for oxygen-evolving photosynthesis and oxygen-sensitive nitrogen fixation, the Nif1-type system probably branched from an ancestral Nif2-type system and has evolved for an exclusive operation within heterocysts.	Oxygen	63-69	zinc finger protein 335	Homo sapiens	156-160
2419007-5	1986	NADPH-cytochrome P-450 reductase and similar flavo-enzymes activate quinones via one-electron reduction into semiquinone free radicals, which then react with molecular oxygen, forming superoxide anions.	Oxygen	168-174	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	0-32
7553327-6	1995	The increase in aerobic metabolic rate in the red soleus only might indicate that the isozyme CA III, which is present only in this type of muscle, is in some way involved in keeping the oxygen consumption low.	Oxygen	187-193	carbonic anhydrase 3	Rattus norvegicus	94-100
28741778-1	1993	The ubiquitous and obligatory association of cytochrome b-559 with the photosystem II reaction center of oxygenic photosynthesis is a conundrum since it seems not to have a function in the primary electron transport pathway of oxygen evolution.	Oxygen	105-111	mitochondrially encoded cytochrome b	Homo sapiens	45-57
18470002-0	1993	Molecular evolutionary analysis of the psbP gene family of the photosystem II oxygen-evolving complex in Nicotiana.	Oxygen	78-84	oxygen-evolving enhancer protein 2-2, chloroplastic	Nicotiana tabacum	39-43
3944767-6	1986	Similarly, 1 micrograms/ml, but not 0.1 ng/ml, of PAF attenuated constriction induced by ventilation with 3% O2.	Oxygen	109-111	PCNA clamp associated factor	Rattus norvegicus	50-53
18470002-1	1993	Photosystem II psbP protein of the oxygen-evolving complex is involved in the photosynthetic oxygen evolution in plants.	Oxygen	35-41	oxygen-evolving enhancer protein 2-2, chloroplastic	Nicotiana tabacum	15-19
18470002-1	1993	Photosystem II psbP protein of the oxygen-evolving complex is involved in the photosynthetic oxygen evolution in plants.	Oxygen	93-99	oxygen-evolving enhancer protein 2-2, chloroplastic	Nicotiana tabacum	15-19
8477727-0	1993	Transcriptional control of AAC3 gene encoding mitochondrial ADP/ATP translocator in Saccharomyces cerevisiae by oxygen, heme and ROX1 factor.	Oxygen	112-118	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	27-31
7662713-0	1995	Pronounced activation of protein kinase C, ornithine decarboxylase and c-jun proto-oncogene by paraquat-generated active oxygen species in WI-38 human lung cells.	Oxygen	121-127	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
7662713-11	1995	We therefore propose that superoxide anion (O2- and H2O2 generated by PQ could activate PKC and lead to induction of c-jun gene expression; on the other hand, O2- and .OH might trigger other kinase pathways to elevate ODC activity.	Oxygen	44-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
7662713-11	1995	We therefore propose that superoxide anion (O2- and H2O2 generated by PQ could activate PKC and lead to induction of c-jun gene expression; on the other hand, O2- and .OH might trigger other kinase pathways to elevate ODC activity.	Oxygen	54-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
7664731-5	1995	The tha1 mutation interferes with the targeting of one chloroplast-encoded protein, cytochrome f, and three nuclear-encoded proteins, plastocyanin, the psaF gene product and the 33 kDa subunit of the oxygen-evolving complex.	Oxygen	200-206	protein translocase subunit SECA1, chloroplastic	Zea mays	4-8
3948295-1	1986	It is proposed that cells store calcium in the hydrogen belt of their membranes, on the cytoplasmic side, with the Ca2+ ion captive in cages formed by the phosphate and carbonyl oxygens of two acidic phospholipid molecules; for instance, phosphatidylinositol and phosphatidylserine.	Oxygen	178-185	carbonic anhydrase 2	Homo sapiens	115-118
7631858-7	1995	In seven fetuses, reducing fetal arterial O2 tension by approximately 9-10 Torr from a control of 23 +/- 1.3 Torr increased plasma ANP concentrations approximately 2.4 times the control mean of 176 pg/min.	Oxygen	42-44	natriuretic peptides A	Ovis aries	131-134
7603037-11	1995	Exposure to 85% O2 increased the concentration of MnSOD in the mitochondria of interstitial fibroblasts by 197 and 139% after O2 exposure of 7 days and 14 days, respectively.	Oxygen	16-18	superoxide dismutase 2	Rattus norvegicus	50-55
7603037-11	1995	Exposure to 85% O2 increased the concentration of MnSOD in the mitochondria of interstitial fibroblasts by 197 and 139% after O2 exposure of 7 days and 14 days, respectively.	Oxygen	126-128	superoxide dismutase 2	Rattus norvegicus	50-55
7767940-6	1995	Covalent binding of TNT and 4HA was dependent on oxygen concentration.	Oxygen	49-55	troponin T3, fast skeletal type	Rattus norvegicus	20-23
7767940-7	1995	Higher levels of covalent adducts were formed when TNT was incubated aerobically (up to 50% oxygen concentration) than under anaerobic conditions.	Oxygen	92-98	troponin T3, fast skeletal type	Rattus norvegicus	51-54
7656377-2	1995	Hypoxia (3% oxygen) significantly increased PDGF-B chain mRNA in PAEC, whereas mRNA level of PDGF-A chain was not increased significantly in comparison with normoxic control (21% oxygen).	Oxygen	12-18	platelet derived growth factor subunit B	Homo sapiens	44-50
7759520-3	1995	Cytochrome b558 purified from pig neutrophils was studied to characterize the spin state of the heme iron in relation to its O2-.	Oxygen	125-127	cytochrome b	Sus scrofa	0-12
7759520-13	1995	forming activity decreased concomitant with loss of the low-spin heme, which provides direct evidence that the low-spin state of cytochrome b558 is essential to generate O2-.	Oxygen	170-172	cytochrome b	Sus scrofa	129-141
7750307-4	1995	When compared with normally nourished individuals (GPs 2 and 3), malnourished GP1 patients showed greater reduction in maximal workload and in peak O2 uptake (VO2 peak), with earlier onset of metabolic acidosis (anaerobic threshold [AT]); in addition, indexes reflecting O2 cost of ventilation were higher in GP1.	Oxygen	148-150	GTP binding protein 1	Homo sapiens	78-81
7750307-4	1995	When compared with normally nourished individuals (GPs 2 and 3), malnourished GP1 patients showed greater reduction in maximal workload and in peak O2 uptake (VO2 peak), with earlier onset of metabolic acidosis (anaerobic threshold [AT]); in addition, indexes reflecting O2 cost of ventilation were higher in GP1.	Oxygen	160-162	GTP binding protein 1	Homo sapiens	78-81
7896790-5	1995	This activity exhibited an absolute requirement for the cytosolic activating factor p67phox but not for p47phox, suggesting that p67phox and p47phox have individual roles in controlling electron flow from NADPH to oxygen.	Oxygen	214-220	neutrophil cytosolic factor 1	Homo sapiens	141-148
7896790-6	1995	Here, we provide direct evidence that p67phox alone can facilitate electron flow from NADPH to the flavin center of NADPH oxidase in the absence of p47phox, resulting in the reduction of enzyme FAD, whereas the presence of p47phox is required in order for electron transfer to proceed beyond the flavin center to the heme in cytochrome b-245 and thence to oxygen.	Oxygen	356-362	neutrophil cytosolic factor 1	Homo sapiens	223-230
7896790-6	1995	Here, we provide direct evidence that p67phox alone can facilitate electron flow from NADPH to the flavin center of NADPH oxidase in the absence of p47phox, resulting in the reduction of enzyme FAD, whereas the presence of p47phox is required in order for electron transfer to proceed beyond the flavin center to the heme in cytochrome b-245 and thence to oxygen.	Oxygen	356-362	mitochondrially encoded cytochrome b	Homo sapiens	325-337
7893699-1	1995	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) is a copper, ascorbate, and molecular oxygen dependent enzyme that plays a key role in the biosynthesis of many peptides.	Oxygen	40-46	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
7852403-1	1995	The effect of pyridine on the heme environment of cytochrome b558 was studied using ESR and optical absorption spectroscopy in relation to the O2(-)-generating activity in the NADPH oxidase system of stimulated pig neutrophils.	Oxygen	143-145	cytochrome b	Sus scrofa	50-62
7852403-6	1995	The results provide further evidence that a low-spin heme iron of cytochrome b558 with a g-value of 3.2 is essential to the O2(-)-forming reaction of the NADPH oxidase system.	Oxygen	124-126	cytochrome b	Sus scrofa	66-78
7864872-2	1995	The analysis of hyperbaric oxygen treated lenses revealed the formation in the intact cultured lens of an enzyme form displaying affinity column binding properties, specific activity, sensitivity to inhibition and susceptibility to activation by thiol reducing agents, all comparable to glutathione modified aldose reductase.	Oxygen	27-33	aldose reductase	Bos taurus	308-324
7602469-4	1995	The IC50 values for catechin, and procyanidin B-2 to inhibit oxygen consumption were 34.0 and 11.0 microM.	Oxygen	61-67	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	46-49
7811728-0	1995	Hemoglobin Roanne [alpha 94(G1) Asp--&gt;Glu]: a variant of the alpha 1 beta 2 interface with an unexpected high oxygen affinity.	Oxygen	113-119	proline rich protein BstNI subfamily 3	Homo sapiens	0-30
7840232-6	1995	Increased mRNA expressions of interstitial collagenase and TIMP preceded those of type I collagen and TGF-beta 1, occurring at 4-6 days of exposure to 85% O2, while there was no significant change in stromelysin mRNA.	Oxygen	155-157	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	59-63
7546271-8	1995	The presentation of ICAM-1, E-selectin and VCAM-1 remained on the whole unaffected by both hypoxia and hyperoxic conditioning after both 7 and 24 h. Stimulation of ICAM-1 by cytokines and LPS was only marginally influenced by the oxygen tension.	Oxygen	230-236	intercellular adhesion molecule 1	Homo sapiens	164-170
8584670-5	1995	Using O2, the substrates are oxidatively cleaved by PAO to form equimolar amounts of an amine, an aldehyde and hydrogen peroxide.	Oxygen	6-8	polyamine oxidase	Homo sapiens	52-55
8545580-8	1995	The "critical PO2" (tissue oxygen partial pressure), which induces neovascularization in miniature pigs has not been determined.	Oxygen	27-33	PO2	Sus scrofa	14-17
7802659-3	1994	Purification of the enzymes indicated that the oxygen-dependent enzyme was a flavoenzyme, retinal oxidase (EC 1.2.3.11), composed of two 135 kDa subunits; and the NAD(+)-dependent enzyme was a basic pI retinal dehydrogenase composed of four 55-kDa subunits.	Oxygen	47-53	aldehyde oxidase 1	Oryctolagus cuniculus	90-105
7896626-5	1994	Horses ran at 50, 75, and 100% of maximal O2 consumption on a treadmill.	Oxygen	42-44	RAN, member RAS oncogene family	Equus caballus	7-10
7846162-3	1994	In hypoxic seedlings with the roots in solution sparged with 5% (v/v) O2 (balance N2) and the shoots in the same gaseous atmosphere, mRNAs for Pdc1 and Adh2 in root tips both increased about 15-fold during the first 12 h, followed by a decline toward initial levels by 18 to 24h.	Oxygen	70-72	pyruvate decarboxylase 1	Zea mays	143-147
7868455-1	1994	In a previous study we found a significant temporary decrease in the ratio of CD4/CD8 (helper, inducer/suppressor, cytotoxic) T lymphocytes in the peripheral blood of healthy human volunteers after exposure to a single commonly used profile of hyperbaric oxygen (HBO).	Oxygen	255-261	CD8a molecule	Homo sapiens	82-85
21607511-5	1994	Intraspheroidal oxygen tensions (Po-2) measured with microelectrodes were less in 5% O-2 than in 20% O-2, yet did not vary systematically as a function of external lactate.	Oxygen	16-22	immunoglobulin kappa variable 1D-39	Homo sapiens	85-88
21607511-5	1994	Intraspheroidal oxygen tensions (Po-2) measured with microelectrodes were less in 5% O-2 than in 20% O-2, yet did not vary systematically as a function of external lactate.	Oxygen	16-22	immunoglobulin kappa variable 1D-39	Homo sapiens	101-104
7934100-2	1994	The hypothesis is that more oxygen will dissociate from hemoglobin in a blood cardioplegic solution with a higher hemoglobin content than from a cardioplegic solution with a lower hemoglobin content.	Oxygen	28-34	HGB	Sus scrofa	114-124
7934100-2	1994	The hypothesis is that more oxygen will dissociate from hemoglobin in a blood cardioplegic solution with a higher hemoglobin content than from a cardioplegic solution with a lower hemoglobin content.	Oxygen	28-34	HGB	Sus scrofa	114-124
7934100-3	1994	However, the increment in the volume of oxygen that dissociates from hemoglobin will be less than anticipated by a ratio of hemoglobin concentrations in the cardioplegic solution.	Oxygen	40-46	HGB	Sus scrofa	69-79
7934100-3	1994	However, the increment in the volume of oxygen that dissociates from hemoglobin will be less than anticipated by a ratio of hemoglobin concentrations in the cardioplegic solution.	Oxygen	40-46	HGB	Sus scrofa	124-134
7934100-9	1994	These limitations may be obviated by methods that increase the dissolved oxygen content of the cardioplegic solution or methods that decrease the affinity of hemoglobin for oxygen under conditions of hypothermia and alkalosis.	Oxygen	173-179	HGB	Sus scrofa	158-168
7660717-2	1994	Placental microsomes are involved in the metabolism of steroid hormones via NADPH cytochrome P450 reductase; this last enzyme is involved in the generation of O2 and H2O2.	Oxygen	159-161	cytochrome p450 oxidoreductase	Rattus norvegicus	76-107
8441566-1	1993	Since very low birth weight preterm newborns are prone to oxygen toxicity and have red blood cells that have a high oxygen affinity, the knowledge of the P90 (the PaO2 required for 90% saturation of hemoglobin) could result in a more optimal oxygenation.	Oxygen	58-64	cellular inhibitor of PP2A	Homo sapiens	154-157
8441566-1	1993	Since very low birth weight preterm newborns are prone to oxygen toxicity and have red blood cells that have a high oxygen affinity, the knowledge of the P90 (the PaO2 required for 90% saturation of hemoglobin) could result in a more optimal oxygenation.	Oxygen	116-122	cellular inhibitor of PP2A	Homo sapiens	154-157
8441566-6	1993	Measurement of oxygen saturation, pH, and PaO2 provided the information for plotting the oxygen dissociation curve, the P50 and P90.	Oxygen	15-21	cellular inhibitor of PP2A	Homo sapiens	128-131
8273928-1	1993	Mixed venous oxygen saturation (SvO2), measured on pulmonary artery blood, is a convenient indicator of matching between O2 transport (TaO2) and O2 body consumption (VO2).	Oxygen	13-19	TAO kinase 2	Homo sapiens	135-139
8273928-1	1993	Mixed venous oxygen saturation (SvO2), measured on pulmonary artery blood, is a convenient indicator of matching between O2 transport (TaO2) and O2 body consumption (VO2).	Oxygen	34-36	TAO kinase 2	Homo sapiens	135-139
8273928-1	1993	Mixed venous oxygen saturation (SvO2), measured on pulmonary artery blood, is a convenient indicator of matching between O2 transport (TaO2) and O2 body consumption (VO2).	Oxygen	121-123	TAO kinase 2	Homo sapiens	135-139
8050387-3	1993	the administration of exogenous insulin to dogs subjected to hypothermia causes a calorigenic effect by enhancing oxygen consumption and rising the intensity of shivering thermogenesis.	Oxygen	114-120	insulin	Canis lupus familiaris	32-39
7509981-9	1993	These results suggest that ET-1 decreases oxygen supply to the cardiac muscles by constricting coronary vessels and that this, in turn, worsens the ischemic condition of the heart to extend the infarct size.	Oxygen	42-48	endothelin-1	Oryctolagus cuniculus	27-31
10172011-8	1993	The venous oxygen saturation values obtained from the Oxysat and the MX2 devices correlated well with the ABL500 over the entire range of blood flows, temperatures, and hematocrits.	Oxygen	11-17	MX dynamin like GTPase 2	Homo sapiens	69-72
1303439-6	1992	The immunohistochemical method using the antibody against human PS apoprotein is worth applying for the diagnosis of oxygen deficiency including the respiratory distress syndrome (RDS) of the new born.	Oxygen	117-123	surfactant protein D	Homo sapiens	64-77
1445949-1	1992	The oxidation of 3,4-dihydroxyphenylalanine (dopa) by O2 catalyzed by tyrosinase yields 4-(2-carboxy-2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaquinone-H+).	Oxygen	54-56	tyrosinase	Homo sapiens	70-80
1445836-4	1992	The photoreaction of thymine with NAT is completely quenched by oxygen and cannot be sensitized by acetone.	Oxygen	64-70	bromodomain containing 2	Homo sapiens	34-37
1338273-0	1992	O2- scavenging activity of lignins, tannins and PSK.	Oxygen	0-2	TAO kinase 2	Homo sapiens	48-51
1491115-5	1992	A hypothetical signal chain is described which suggests the involvement of cytochrome b as an O2 sensor in PO2 chemoreception of the carotid body and the degradation of H2O2 by glutathione to control the K(+)-conductivity of carotid body cells.	Oxygen	94-96	cytochrome b, mitochondrial	Rattus norvegicus	75-87
1397323-6	1992	PCK activity and PCK mRNA were elevated to 100% at 16% O2 and to about 65% at 8% O2.	Oxygen	55-57	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
1397323-6	1992	PCK activity and PCK mRNA were elevated to 100% at 16% O2 and to about 65% at 8% O2.	Oxygen	55-57	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	17-20
1397323-6	1992	PCK activity and PCK mRNA were elevated to 100% at 16% O2 and to about 65% at 8% O2.	Oxygen	81-83	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
1397323-6	1992	PCK activity and PCK mRNA were elevated to 100% at 16% O2 and to about 65% at 8% O2.	Oxygen	81-83	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	17-20
1397323-11	1992	These findings support the hypothesis that a heme protein is involved in the activation of the PCK gene and that it acts as an O2 sensor.	Oxygen	127-129	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	95-98
1427042-2	1992	The variant alpha-globin, designated chain 5m in the Hbag2 haplotype, had an high oxygen affinity and was stable.	Oxygen	82-88	hemoglobin alpha, adult chain 1	Mus musculus	12-24
1427042-3	1992	The variant beta-globin, (beta s2) of the Hbbs2 haplotype, also had an elevated oxygen affinity and in addition was moderately unstable in 19% isopropanol.	Oxygen	80-86	hemoglobin beta chain complex	Mus musculus	12-23
1326544-1	1992	Cytochrome b558 in phagocytes is a transmembrane protein composed of large and small subunits and considered to play a key role in O2- generation during the respiratory burst.	Oxygen	131-133	mitochondrially encoded cytochrome b	Homo sapiens	0-12
1325837-8	1992	The O2(-)-forming NADPH oxidase associated in the membranes was solubilized with heptyl-thio-glucoside at 0 degree C and concentrated up to 45 microM cyt b-558 with no modification of the heme moiety confirmed by its O2(-)-generating activity and lack of carbon monoxide-binding capacity.	Oxygen	4-6	cytochrome b	Sus scrofa	150-155
1525167-0	1992	Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation.	Oxygen	24-30	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
1415559-6	1992	At 1 day after IL-1 (5 micrograms) insufflation and O2 exposure, levels of Mn SOD mRNA and specific protein, but not enzyme activity, were markedly elevated.	Oxygen	52-54	superoxide dismutase 2	Rattus norvegicus	75-81
1415559-7	1992	At 2.3 and 7 days after O2 exposure, levels of Mn SOD mRNA, specific protein, and enzyme activity were all increased in IL-1-treated animals.	Oxygen	24-26	superoxide dismutase 2	Rattus norvegicus	47-53
1415559-8	1992	In contrast, in control rats at 2.3 days after O2 exposure, level of Mn SOD mRNA was markedly elevated, whereas levels of specific protein and enzyme activity were decreased.	Oxygen	47-49	superoxide dismutase 2	Rattus norvegicus	69-75
1324315-7	1992	A metabolically stable LTA4 hydrolase inhibitor, RP64966, was obtained by insertion of an oxygen atom in the beta-position on the carboxylic acid side chain.	Oxygen	90-96	leukotriene A4 hydrolase	Rattus norvegicus	23-37
10004150-0	1992	Spin-resolved photoemission study of the reaction of O2 with fcc Co(100).	Oxygen	53-55	spindlin 1	Homo sapiens	0-4
1380809-6	1992	KShIIIC and KShIIID currents are very similar to an O2-sensitive K+ current present in type I cells of the carotid body which is believed to underlie the modulation of excitability of these cells by changes in arterial O2 pressure.	Oxygen	52-54	potassium channel, voltage gated Shaw related subfamily C, member 3 L homeolog	Xenopus laevis	12-19
1380809-6	1992	KShIIIC and KShIIID currents are very similar to an O2-sensitive K+ current present in type I cells of the carotid body which is believed to underlie the modulation of excitability of these cells by changes in arterial O2 pressure.	Oxygen	219-221	potassium channel, voltage gated Shaw related subfamily C, member 3 L homeolog	Xenopus laevis	12-19
1636726-13	1992	These results support an important role of Mn SOD in the protection against O2 toxicity.	Oxygen	76-78	superoxide dismutase 2	Rattus norvegicus	43-49
1618766-6	1992	Present results show that CO and O2 bindings to the heme iron of Mb are controlled by Leu29(B10) by influencing the structure of close vicinity of the heme and the geometry of iron-bound ligand.	Oxygen	33-35	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	92-95
1535251-2	1992	Chronic infusions of ANP have been shown to limit the anatomical pulmonary vascular remodelling associated with chronic exposure to a 10% oxygen environment.	Oxygen	138-144	natriuretic peptide A	Rattus norvegicus	21-24
1320745-8	1992	Therefore, it is possible to hypothesize that an electron leakage at the level of the auto-oxidizing chain components (i.e., cytochrome b and ubiquinone populations) increases the release of activated oxygen species (superoxide radical, hydroxyl radical).	Oxygen	201-207	cytochrome b, mitochondrial	Rattus norvegicus	125-137
1499021-4	1992	The coordination number of the Li+ is 5 and it is bonded to two water molecules and three hydroxyl oxygen atoms of two ascorbate anions: O-2 and the gauche O-5, 6 of the side chain.	Oxygen	99-105	immunoglobulin kappa variable 1D-39	Homo sapiens	137-140
1554747-6	1992	In both cell types, hypoxia (0% O2) significantly reduced the amount of ET-1 at 48 h. Restoration of normoxia in 21% O2 for 48 h resulted in a return of ET-1 levels to baseline.	Oxygen	32-34	endothelin 1	Bos taurus	72-76
10045198-0	1992	Spin exchange in elastic e-O2 collisions.	Oxygen	27-29	spindlin 1	Homo sapiens	0-4
1510828-2	1992	Since C19 steroids with an oxygen function at C11 have not been recorded as products of steroid biosynthesis in normal mammalian testes, we have examined their possible production in purified preparations of porcine Leydig cells.	Oxygen	27-33	RNA polymerase III subunit K	Homo sapiens	46-49
1552891-1	1992	In in-vitro study, human immunoglobulin (Ig) denatured by O2 bubbling markedly produced C4a, C3a, and C5a, whereas human albumin treated identically did not.	Oxygen	58-60	complement C3	Homo sapiens	93-96
1552891-2	1992	White blood cells (WBC) treated by O2 bubbling significantly increased C3a levels alone, but at a much lesser grade than the Ig.	Oxygen	35-37	complement C3	Homo sapiens	71-74
7841336-5	1994	In the NADPH/oxygen-supported cytochrome P450-catalyzed 4-hydroxylation of the anilines a correlation of the natural logarithm of kcats with E(HOMO) was not observed and the kcats values were lower than observed in the iodosobenzene-supported reaction.	Oxygen	13-19	2,4-dienoyl-CoA reductase 1	Homo sapiens	7-12
7841336-6	1994	From this result it is concluded that, although the NADPH/oxygen-supported microsomal 4-hydroxylation of the halogenated anilines proceeds by the same cytochrome P450 (FeO)3+ intermediate and, thus, by a similar electrophilic attack of the (FeO)3+ on the pi electrons of the substrate, this attack is no longer the rate-limiting step of the reaction.	Oxygen	58-64	2,4-dienoyl-CoA reductase 1	Homo sapiens	52-57
7841336-7	1994	Additional results of the present study demonstrate that the apparent Michaelis constant Kms of the NADPH/oxygen-supported 4-hydroxylation of the anilines decreases with increasing hydrophobicity of the aniline derivatives.	Oxygen	106-112	2,4-dienoyl-CoA reductase 1	Homo sapiens	100-105
7913906-8	1994	When the bolus injection was followed by a continuous infusion of somatostatin, the reduction in gastric perfusion, as assessed by means of laser-Doppler flowmetry, was maintained, although the magnitude of the reduction (-17% +/- 7%) was significantly lower than that observed immediately after the bolus (p &lt; 0.05); the hemoglobin content of the gastric mucosa was also significantly reduced (-8% +/- 1%), but no changes were observed in the oxygen content.	Oxygen	447-453	somatostatin	Homo sapiens	66-78
7933490-1	1994	To prevent hypoxemia during one-lung anesthesia, we have devised an oxygen insufflation machine which can insufflate oxygen (0.2-10 l.min-1) and apply CPAP (0-30 cmH2O) selectively to the non-ventilated lung.	Oxygen	68-74	centromere protein J	Homo sapiens	151-155
7990976-0	1994	Hypoxia induces release of atrial natriuretic peptide in rat atrial tissue: a role for this peptide during low oxygen stress.	Oxygen	111-117	natriuretic peptide A	Rattus norvegicus	27-53
24310115-13	1994	D1/D2/Cytb559-complexes and PS II membrane fragments deprived of the extrinsic proteins and manganese exhibit no SOD-activity but are capable of producing O2 (-) in the light if a PS II electron donor is added.Based on these results the site(s) of light induced superoxide formation in PS II is (are) inferred to be located at the acceptor side.	Oxygen	155-157	mitochondrially encoded cytochrome b	Homo sapiens	6-10
7913925-9	1994	After reoxygenation (&gt; 90% O2 saturation), CD11b/CD18 expression was restored, and this was abrogated by exposure to cytochalasin B.	Oxygen	30-32	integrin subunit alpha M	Homo sapiens	46-51
1561439-5	1992	Treatment with continuous positive pressure on respiratory tract (cPAP) achieves a significant decrease (p less than 0.001) in the mean duration of apnea and in the apnea-hypopnea/hour index, and it also manages to significantly increase arterial oxygen saturation.	Oxygen	247-253	centromere protein J	Homo sapiens	66-70
3934164-8	1985	Proteins A and C together catalyze the reduction of molecular oxygen to water, a reaction prevented by protein B.	Oxygen	62-68	prolyl 3-hydroxylase 3	Homo sapiens	103-112
1337650-3	1992	Similarly, spin lattice relaxation times of perfluorocarbon emulsions are oxygen sensitive, and this property has been taken advantage of to produce oxygen maps of brain by fluorine NMR imaging.	Oxygen	74-80	spindlin 1	Homo sapiens	11-15
1337650-3	1992	Similarly, spin lattice relaxation times of perfluorocarbon emulsions are oxygen sensitive, and this property has been taken advantage of to produce oxygen maps of brain by fluorine NMR imaging.	Oxygen	149-155	spindlin 1	Homo sapiens	11-15
8130204-1	1994	The respiratory burst oxidase of neutrophils is a multicomponent enzyme, dormant in resting cells, that catalyzes the reduction of oxygen to O2- at the expense of NADPH.	Oxygen	131-137	2,4-dienoyl-CoA reductase 1	Homo sapiens	163-168
8130204-1	1994	The respiratory burst oxidase of neutrophils is a multicomponent enzyme, dormant in resting cells, that catalyzes the reduction of oxygen to O2- at the expense of NADPH.	Oxygen	141-143	2,4-dienoyl-CoA reductase 1	Homo sapiens	163-168
4096211-2	1985	Following short-term exposure of the cornea to low atmospheric oxygen pressures, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) activities in tears are altered so that the tear LDH/MDH ratio is elevated.	Oxygen	63-69	malic enzyme 1	Homo sapiens	193-196
8125748-14	1994	We estimate that a lens with an oxygen transmissibility (Dk/L) of 300 x 10(-11) (cm/sec)(ml O2/ml x mm Hg) is needed to prevent epithelial pHi changes in the open eye.	Oxygen	32-38	glucose-6-phosphate isomerase	Oryctolagus cuniculus	139-142
8125748-14	1994	We estimate that a lens with an oxygen transmissibility (Dk/L) of 300 x 10(-11) (cm/sec)(ml O2/ml x mm Hg) is needed to prevent epithelial pHi changes in the open eye.	Oxygen	92-94	glucose-6-phosphate isomerase	Oryctolagus cuniculus	139-142
1295670-6	1992	It is postulated that (i) large increases in [Ca2+]i in cerebral neurones during ischaemia are related to the high density of pathways on neurones that allow calcium entry; (ii) differences in the amount of calcium accumulated during periods of oxygen deprivation between neurones of the Ca1 and CA3 regions are linked to the level of glutamatergic input (and hence excitatory synapses) that the two areas receive; (iii) restitution of blood flow and consequent rapid restoration of ATP synthesis permit reactivation of calcium-eliminating mechanisms.	Oxygen	245-251	carbonic anhydrase 2	Homo sapiens	46-49
1450988-9	1992	S[La]2 corresponded to the second breaking point of the lactate time-course curve (onset of blood lactate accumulation) and SV2 was identified at the second breaking point in the increase in VE and ventilatory equivalent for O2 uptake accompanied by a concomitant increase in ventilatory equivalent for CO2 output.	Oxygen	225-227	synaptic vesicle glycoprotein 2A	Homo sapiens	124-127
4073286-2	1985	Rightward shifts of the O2 dissociation curve (ODC), obtained by lysing and resealing erythrocytes to encapsulate inositol hexaphosphate (IHP), led to a very large increase in P50 without side effects.	Oxygen	24-26	activating signal cointegrator 1 complex subunit 1	Homo sapiens	176-179
1542209-13	1992	PAM with TNF-alpha pretreatment, and PAM with IFN-gamma pretreatment could release increased amount of O2- significantly, compared with control.	Oxygen	103-105	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
1542209-14	1992	PAM with IL-2 pretreatment and PAM with GM-CSF pretreatment also released somewhat increased amount of O2-.	Oxygen	103-105	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	0-3
1542209-14	1992	PAM with IL-2 pretreatment and PAM with GM-CSF pretreatment also released somewhat increased amount of O2-.	Oxygen	103-105	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	31-34
1660188-4	1991	Gox was purified and shown to augment the rate of O2- production in a cell-free oxidase activation system.	Oxygen	50-52	hydroxyacid oxidase 1	Homo sapiens	0-3
8023703-1	1994	The phenomenon was oxygen-dependent, and the intensity of emission could be suppressed by post-irradiation treatment with catalase, superoxide dismutase, and ascorbic acid.	Oxygen	19-25	catalase-4	Cicer arietinum	122-130
18965950-2	1994	The used enzymatic reaction consisted of the oxidation of the phenolic compounds by oxygen, catalysed by tyrosinase.	Oxygen	84-90	tyrosinase	Homo sapiens	105-115
10011515-0	1994	STM study of oxygen on Rh(110).	Oxygen	13-19	sulfotransferase family 1A member 3	Homo sapiens	0-3
4073286-8	1985	These experiments have demonstrated that if O2 uptake by erythrocytes remains constant, in the presence of a high P50, sufficient O2 supply may be achieved with substantially less blood flow.	Oxygen	44-46	activating signal cointegrator 1 complex subunit 1	Homo sapiens	114-117
4073286-8	1985	These experiments have demonstrated that if O2 uptake by erythrocytes remains constant, in the presence of a high P50, sufficient O2 supply may be achieved with substantially less blood flow.	Oxygen	130-132	activating signal cointegrator 1 complex subunit 1	Homo sapiens	114-117
1687664-1	1991	We have previously shown that exposure to 100% oxygen for 2 h results in a two-fold decrease in the brain glutamine synthetase activity of neonatal rats.	Oxygen	47-53	glutamate-ammonia ligase	Rattus norvegicus	106-126
3936749-2	1985	A step change in arterial oxygen content (1.75 to 15.3 ml O2/100 ml) was followed by a decrease in coronary flow, an increase in aortic flow, external work, myocardial oxygen consumption and efficiency, respectively.	Oxygen	26-32	immunoglobulin kappa variable 1D-39	Homo sapiens	58-64
1662085-2	1991	This apparatus was previously employed to measure spin label pharmacokinetics of nitroxide sensitive to oxygen in whole mice.	Oxygen	104-110	spindlin 1	Mus musculus	50-54
8117326-7	1994	The addition of superoxide dismutase (SOD) and catalase in the auto-oxidation experiments each decreased the rate of oxygen consumption, indicating that O2- and H2O2 are generated during auto-oxidation.	Oxygen	117-123	immunoglobulin kappa variable 1D-39	Homo sapiens	153-165
24185976-3	1994	In the search for a possible biochemical activity of this uncommon tricyclic compound we have assayed whether it could interact with oxygen reactive species (H2O2, O2 (-),( )OH) thus exhibiting a scavenging effect of possible biomedical interest.	Oxygen	133-139	immunoglobulin kappa variable 1D-39	Homo sapiens	158-166
2996947-7	1985	Priming can be explained at least in part by a modification of the respiratory burst enzyme such that it binds its substrate NADPH, the source of electrons for reduction of oxygen to superoxide anion, more efficiently.	Oxygen	173-179	2,4-dienoyl-CoA reductase 1	Homo sapiens	125-130
7994360-0	1994	Increased vascular resistance with hemoglobin-based oxygen carriers.	Oxygen	52-58	HGB	Sus scrofa	35-45
7994360-1	1994	PURPOSE: To compare the effects of resuscitation with hemoglobin-based oxygen-carriers and conventional resuscitation fluids on hemodynamics, oxygen transport, and oxygen consumption in an animal model of the use of these fluids in the treatment of hemorrhagic shock.	Oxygen	71-77	HGB	Sus scrofa	54-64
1959410-6	1991	However, P(A-a)O2 was significantly greater at 120 min in the CPAP group.	Oxygen	15-17	centromere protein J	Homo sapiens	62-66
1959410-7	1991	Within the CPAP group, P(A-a)O2 was also significantly worse at 120 vs 0 min.	Oxygen	29-31	centromere protein J	Homo sapiens	11-15
7994360-5	1994	CONCLUSIONS: Increased vascular resistance limits the oxygen transport benefit of cell-free-hemoglobin-based oxygen carriers.	Oxygen	54-60	HGB	Sus scrofa	92-102
2991376-0	1985	Macrophage colony-stimulating factor (M-CSF) enhances the capacity of murine macrophages to secrete oxygen reduction products.	Oxygen	100-106	colony stimulating factor 1 (macrophage)	Mus musculus	0-36
7994360-5	1994	CONCLUSIONS: Increased vascular resistance limits the oxygen transport benefit of cell-free-hemoglobin-based oxygen carriers.	Oxygen	109-115	HGB	Sus scrofa	92-102
7987045-9	1994	The promoters of the grp genes constitutively express their gene products, and their promoter activities can be further enhanced in cellular environments of low glucose or oxygen.	Oxygen	172-178	gastrin releasing peptide	Homo sapiens	21-24
1951723-8	1991	Additionally, the efflux of NPY-LI from dog pulmonary artery resulting from high frequencies of ES is oxygen sensitive.	Oxygen	102-108	neuropeptide Y	Canis lupus familiaris	28-31
2991376-0	1985	Macrophage colony-stimulating factor (M-CSF) enhances the capacity of murine macrophages to secrete oxygen reduction products.	Oxygen	100-106	colony stimulating factor 1 (macrophage)	Mus musculus	38-43
1810265-1	1991	Inhibition of glucose-6-phosphate dehydrogenase (G6-PDH) by dithranol (anthralin, CAS 480-22-8) has been studied in the presence of catalase, superoxide dismutase (SOD) and various scavengers of active oxygen species.	Oxygen	202-208	glucose-6-phosphate dehydrogenase	Homo sapiens	49-55
2991376-2	1985	Macrophages incubated for 48 hr or more with concentrated L cell-conditioned medium as a source of M-CSF released two to three times as much O2- in response to PMA as did unexposed macrophages.	Oxygen	141-143	colony stimulating factor 1 (macrophage)	Mus musculus	99-104
2991376-5	1985	Release of O2- by M-CSF macrophages occurred over 60 min and was triggered by opsonized zymosan as well as PMA.	Oxygen	11-13	colony stimulating factor 1 (macrophage)	Mus musculus	18-23
1776367-6	1991	The gradient of the partial oxygen pressure (PO2) could provide the conditions for the Pasteur effect, which, however, has not yet been clearly observed.	Oxygen	28-34	PO2	Sus scrofa	45-48
7532995-5	1994	With films deposited using oxygen-containing monomers, the initial attachment and spreading of endothelial cells failed when the medium contained 15% (v/v) serum from which both fibronectin (Fn) and vitronectin (Vn) had been removed.	Oxygen	27-33	vitronectin	Homo sapiens	199-210
7532995-5	1994	With films deposited using oxygen-containing monomers, the initial attachment and spreading of endothelial cells failed when the medium contained 15% (v/v) serum from which both fibronectin (Fn) and vitronectin (Vn) had been removed.	Oxygen	27-33	vitronectin	Homo sapiens	212-214
7532995-6	1994	Similarly, initial attachment and spreading of endothelial cells onto films deposited using oxygen-containing monomers were reduced by 62-86% when the cells were seeded in medium containing Vn-depleted serum (which contained Fn).	Oxygen	92-98	vitronectin	Homo sapiens	190-192
2991376-7	1985	These data indicate that M-CSF enhances the capacity of mature macrophages to release oxygen reduction products, and they are consistent with reports that CSF can stimulate the release of other secretory products.	Oxygen	86-92	colony stimulating factor 1 (macrophage)	Mus musculus	25-30
1904467-13	1991	Low oxygen tension is favorable for both melanocyte proliferation and tyrosinase activity.	Oxygen	4-10	tyrosinase	Homo sapiens	70-80
2036446-2	1991	Phenylhydrazine has been previously shown to trigger the production of toxic oxygen metabolites including O-2 and H2O2 and the formation of Heinz bodies.	Oxygen	77-83	immunoglobulin kappa variable 1D-39	Homo sapiens	106-109
8227796-9	1993	Directly measured myocardial oxygen consumption had a linear relation to the mean C-11 clearance rate (r = 0.8, p = 0.018).	Oxygen	29-35	RNA polymerase III subunit K	Homo sapiens	82-86
8227796-15	1993	The use of the C-11 acetate PET for determining myocardial oxygen consumption and estimating efficiency could potentially complement existing clinical measures of ventricular performance and may allow improved and objective evaluation of therapy in patients with heart failure.	Oxygen	59-65	RNA polymerase III subunit K	Homo sapiens	15-19
8123719-1	1993	An enzyme-amperometric method is proposed for the analysis of total phenols and L-dopa; the method is based on the enzyme tyrosinase, which is immobilized in a Nylon membrane and coupled to an oxygen gas-diffusion amperometric electrode.	Oxygen	193-199	tyrosinase	Homo sapiens	122-132
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	48-50	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	135-139
4052574-3	1985	Solute quenching studies of the tryptophan fluorescence of parvalbumin reveal dynamic quenching rate constants, kq, of 1.1 X 10(8) and 2.3 X 10(9) M-1 s-1 (at 25 degrees C) with acrylamide and oxygen, respectively, as quenchers.	Oxygen	193-199	parvalbumin	Homo sapiens	59-70
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	48-50	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	187-191
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	170-172	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	135-139
8246886-5	1993	Further experiments demonstrated the ability of O2 to rescue a gcn4 mutant grown in the presence of aminotriazole, an inhibitor of the HIS3 gene product, suggesting that O2 activates the HIS3 gene, gene normally under control of GCN4.	Oxygen	170-172	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	187-191
8399183-1	1993	In addition to the physiological reactions catalyzed by acetolactate synthase, it supports an oxygen-consuming side reaction.	Oxygen	94-100	olfactory receptor family 10 subfamily B member 1 pseudogene	Homo sapiens	56-77
1900435-2	1991	Tyrosinase catalyzes the oxidation by molecular oxygen of L-dopa to o-dopaquinone, which evolves non-enzymatically through a branched pathway with cyclization or hydroxylation reactions.	Oxygen	48-54	tyrosinase	Homo sapiens	0-10
1781304-7	1991	At P14 and P21, the calculated amount of oxygen used by the brain for the oxidation of ketone bodies was twice as high in barbiturate- as in saline-treated rats and reached values of 47 and 16% respectively in phenobarbital-exposed animals.	Oxygen	41-47	KRAS proto-oncogene, GTPase	Rattus norvegicus	11-14
4016147-8	1985	The O2 consumption of liver tissue and hepatocytes is significantly increased by sulfite due to the high activities of sulfite oxidase.	Oxygen	4-6	sulfite oxidase	Homo sapiens	119-134
1905936-4	1991	In contrast, in advanced stages of late-onset DAT, this imbalance between oxygen and glucose utilization rates in the brain became smaller and smaller, and cerebral blood flow diminished markedly; these biological brain parameters finally all settled down at between 55% and 65% of the corresponding control values.	Oxygen	74-80	solute carrier family 6 member 3	Homo sapiens	46-49
33874617-5	1993	Modification of the Fe protein is promoted under conditions where O2 (but not O2 - or H2 O2 ) has increased access to the enzyme, but does not allow nitrogenase to function under conditions of O2 stress.	Oxygen	66-68	general transcription factor IIE subunit 1	Homo sapiens	20-22
2861789-2	1985	In the presence of NADPH and molecular oxygen, highly purified preparations of cytochrome P-450 reductase and cytochrome P-450 (isozyme 2) from rabbit liver microsomes catalyze enzyme inactivation.	Oxygen	39-45	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	79-105
33874617-5	1993	Modification of the Fe protein is promoted under conditions where O2 (but not O2 - or H2 O2 ) has increased access to the enzyme, but does not allow nitrogenase to function under conditions of O2 stress.	Oxygen	78-80	general transcription factor IIE subunit 1	Homo sapiens	20-22
33874617-5	1993	Modification of the Fe protein is promoted under conditions where O2 (but not O2 - or H2 O2 ) has increased access to the enzyme, but does not allow nitrogenase to function under conditions of O2 stress.	Oxygen	78-80	general transcription factor IIE subunit 1	Homo sapiens	20-22
8349542-0	1993	An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium.	Oxygen	3-9	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	20-46
1712505-1	1991	The active forms of oxygen (AFA) participate in modulation of mediation processes in patients with systemic lupus erythematosus.	Oxygen	20-26	AFA	Homo sapiens	28-31
2987422-1	1985	Superoxide anion (O-2) is the first metabolite of the monocyte oxygen burst pathway, which plays an important role in the monocyte microbicidal function.	Oxygen	63-69	immunoglobulin kappa variable 1D-39	Homo sapiens	18-21
2077017-3	1990	After training, maximal O2 uptake measured during supine and upright cycling, respectively, increased significantly (P less than 0.05) by 22.9 and 16.1% in the STG and by 6.0 and 14.6% in the UTG.	Oxygen	24-26	chromosome 6 open reading frame 15	Homo sapiens	160-163
8349542-0	1993	An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium.	Oxygen	3-9	coproporphyrinogen III oxidase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	62-66
8349542-2	1993	On the basis of genetic studies, we have suggested that this reaction may be catalyzed by either of two different enzymes, an oxygen-dependent one encoded by hemF or an oxygen-independent enzyme encoded by hemN.	Oxygen	126-132	coproporphyrinogen III oxidase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	158-162
8349542-2	1993	On the basis of genetic studies, we have suggested that this reaction may be catalyzed by either of two different enzymes, an oxygen-dependent one encoded by hemF or an oxygen-independent enzyme encoded by hemN.	Oxygen	169-175	coproporphyrinogen III oxidase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	158-162
8349542-5	1993	The wild-type S. typhimurium strain LT-2 produces an oxygen-dependent coproporphyrinogen oxidase activity detectable in crude extracts, which is not found in hemF mutants and is overproduced in strains carrying the hemF gene on a multicopy plasmid.	Oxygen	53-59	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	70-96
8349542-5	1993	The wild-type S. typhimurium strain LT-2 produces an oxygen-dependent coproporphyrinogen oxidase activity detectable in crude extracts, which is not found in hemF mutants and is overproduced in strains carrying the hemF gene on a multicopy plasmid.	Oxygen	53-59	coproporphyrinogen III oxidase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	158-162
8349542-5	1993	The wild-type S. typhimurium strain LT-2 produces an oxygen-dependent coproporphyrinogen oxidase activity detectable in crude extracts, which is not found in hemF mutants and is overproduced in strains carrying the hemF gene on a multicopy plasmid.	Oxygen	53-59	coproporphyrinogen III oxidase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	215-219
10006776-0	1993	Spin-resolved photoemission study of the clean and oxygen-covered Fe(110) surface.	Oxygen	51-57	spindlin 1	Homo sapiens	0-4
8518372-9	1993	The arterio-venous oxygen content difference decreased from 3.2 +/- 0.8 mL O2/dL to 2.4 +/- 1.0 mL O2/dL (P &lt; 0.01) following urapidil, but did not change during the administration of isosorbide dinitrate.	Oxygen	19-25	immunoglobulin kappa variable 1D-39	Homo sapiens	75-80
8518372-9	1993	The arterio-venous oxygen content difference decreased from 3.2 +/- 0.8 mL O2/dL to 2.4 +/- 1.0 mL O2/dL (P &lt; 0.01) following urapidil, but did not change during the administration of isosorbide dinitrate.	Oxygen	19-25	immunoglobulin kappa variable 1D-39	Homo sapiens	99-104
9995269-0	1990	Role of oxygen in superconductivity of Nd2-xCexCuO4-y studied by x-ray-absorption near-edge structure.	Oxygen	8-14	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	39-42
2075928-5	1990	As hypoxia is universal for any CRD the index of mixed venous blood saturation with O2 (Sv-O2) was considered as a factor determining hypoxic ODC shift and a numerical contribution of hypoxia to P50 changes has been determined.	Oxygen	84-86	immunoglobulin kappa variable 1D-39	Homo sapiens	88-93
2177392-9	1990	Besides, Rb1 could antagonize lipid peroxidation and scavenge oxygen free radicals as well as increase catalase and GSH-PX activities.	Oxygen	62-68	RB transcriptional corepressor 1	Mus musculus	9-12
3921831-9	1985	The finding that, following irradiation under anoxia, post-treatment with O2 (versus that with N2), also lowers the mutation frequency in mei-9 males, indicates that the repair defect in mei-9 does not interfere with oxygen-dependent post-radiation repair.	Oxygen	74-76	meiotic 9	Drosophila melanogaster	138-143
1976721-2	1990	The values obtained were compared with OER and K values determined for ssb formation in lambda DNA irradiated in Escherichia coli as a function of the oxygen concentration.	Oxygen	151-157	single-stranded DNA-binding protein	Escherichia coli	71-74
8477727-1	1993	The AAC3 gene of Saccharomyces cerevisiae encodes a mitochondrial ADP/ATP translocator which is subject to oxygen repression.	Oxygen	107-113	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	4-8
8477727-4	1993	The results of the deletion analysis show that the negative control of the AAC3 gene by oxygen and ROX1 factor is mediated by an upstream repression sequence consisting of a T-rich segment adjacent to the consensus elements that are present in the 5" flanking regions of several other yeast genes.	Oxygen	88-94	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	75-79
8477727-5	1993	An additional upstream repressor site was located within the AAC3 promoter which, however, is not related either to oxygen or to ROX1 factor.	Oxygen	116-122	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	61-65
8477727-7	1993	In addition, they show that the AAC3 gene belongs to the family of yeast genes including TIF51B, COX5b, HEM13 and CYC7 that are negatively regulated by oxygen and heme.	Oxygen	152-158	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	32-36
8477727-7	1993	In addition, they show that the AAC3 gene belongs to the family of yeast genes including TIF51B, COX5b, HEM13 and CYC7 that are negatively regulated by oxygen and heme.	Oxygen	152-158	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	104-109
3921831-9	1985	The finding that, following irradiation under anoxia, post-treatment with O2 (versus that with N2), also lowers the mutation frequency in mei-9 males, indicates that the repair defect in mei-9 does not interfere with oxygen-dependent post-radiation repair.	Oxygen	74-76	meiotic 9	Drosophila melanogaster	187-192
3886727-2	1985	Using whey as substrate, catalase, haemoglobin combined with ascorbic acid and xanthine oxidase inhibitors all provided protection against oxygen toxicity for a strain of Staphylococcus aureus and of Streptococcus agalactiae.	Oxygen	139-145	AT695_RS10915	Staphylococcus aureus	25-33
8510493-4	1993	C-fos-like immunoreactivity was examined at 2, 4, and 6 h after onset of chemically induced seizures or O2 deprivation at both ages.	Oxygen	104-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
2146522-1	1990	We propose that increased formation of oxygen-derived free radicals, such as the superoxide and hydroxyl species, may be responsible for progressive neural degeneration in dementia of the Alzheimer type (DAT).	Oxygen	39-45	solute carrier family 6 member 3	Homo sapiens	204-207
2284312-1	1990	Part 8: The scavenging of the oxygen-free radicals.	Oxygen	30-36	poly(ADP-ribose) polymerase family member 14	Homo sapiens	0-6
6470009-1	1984	Two different methods were used to determine the number of Bohr protons released upon oxygenation of human hemoglobin (Hb A) and Hb A lacking beta 146 His (des-His Hb A) at the pH ranging from pH 5.0 to 9.0 in the presence of 0.1 M Cl- at 25 degrees C. One is the direct differential titration method, the other is based on the measurement of oxygen affinity as a function of pH.	Oxygen	86-92	sodium voltage-gated channel alpha subunit 2	Homo sapiens	119-123
2285779-3	1990	The fractional saturation with oxygen is evaluated by deconvoluting the optical absorption spectra, in the 500-700 nm wavelength region, in terms of oxyhemoglobin, deoxyhemoglobin and methemoglobin spectral components.	Oxygen	31-37	hemoglobin subunit gamma 2	Homo sapiens	184-197
2285779-7	1990	Moreover, for equal amounts of methemoglobin the oxygen affinity is lower and the cooperativity higher for mixed samples than for those auto-oxidized.	Oxygen	49-55	hemoglobin subunit gamma 2	Homo sapiens	31-44
8432858-4	1993	During exposure of adult rats to &gt; 95% O2, lung manganese superoxide dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity.	Oxygen	42-44	superoxide dismutase 2	Rattus norvegicus	51-81
8432858-4	1993	During exposure of adult rats to &gt; 95% O2, lung manganese superoxide dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity.	Oxygen	42-44	superoxide dismutase 2	Rattus norvegicus	83-88
8432858-4	1993	During exposure of adult rats to &gt; 95% O2, lung manganese superoxide dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity.	Oxygen	42-44	superoxide dismutase 2	Rattus norvegicus	154-159
8432858-4	1993	During exposure of adult rats to &gt; 95% O2, lung manganese superoxide dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity.	Oxygen	42-44	superoxide dismutase 2	Rattus norvegicus	154-159
8432858-7	1993	O2 elevated MnSOD mRNA concentration, and increased its stability.	Oxygen	0-2	superoxide dismutase 2	Rattus norvegicus	12-17
8432858-8	1993	O2 plus endotoxin increased the concentration and stability of MnSOD, catalase, and GP mRNAs.	Oxygen	0-2	superoxide dismutase 2	Rattus norvegicus	63-68
6744307-6	1984	Cysteamine autoxidation as measured by O2 uptake at 0.4 mM proceeds through hydrogen peroxide (H2O2) production as evidenced by the regeneration of O2 upon the addition of catalase.	Oxygen	97-99	catalase	Cricetulus griseus	172-180
12231696-1	1993	Alcohol dehydrogenase (ADH) is one of a number of enzymes of glycolysis and fermentation known to be synthesized preferentially under low O2 conditions.	Oxygen	138-140	uncharacterized protein LOC100285036	Zea mays	0-21
12231696-1	1993	Alcohol dehydrogenase (ADH) is one of a number of enzymes of glycolysis and fermentation known to be synthesized preferentially under low O2 conditions.	Oxygen	138-140	uncharacterized protein LOC100285036	Zea mays	23-26
12231696-7	1993	When induction at 6 h was measured over a wide range of O2 concentrations, a peak in ADH activity occurred in all tissues at 4% (v/v) O2.	Oxygen	56-58	uncharacterized protein LOC100285036	Zea mays	85-88
12231696-7	1993	When induction at 6 h was measured over a wide range of O2 concentrations, a peak in ADH activity occurred in all tissues at 4% (v/v) O2.	Oxygen	134-136	uncharacterized protein LOC100285036	Zea mays	85-88
8416301-1	1993	The ferrous iron of hemoglobin is exposed continuously to high concentrations of oxygen and, thereby, is oxidized slowly to methemoglobin, a protein unable to carry oxygen.	Oxygen	81-87	hemoglobin subunit gamma 2	Homo sapiens	124-137
2165073-11	1990	The concomitant disruption of the AAC2 and AAC3, however, results in arrest of cell growth under conditions of low oxygen tension.	Oxygen	115-121	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	43-47
1966550-6	1990	Neutrophils and splenic macrophages obtained from GM-CSF-treated mice (2 micrograms/animal) produced significantly greater amounts of O2- (204 +/- 36 nmoles/10(5) cells) than controls (21 +/- 10 nmoles/10(5) cells).	Oxygen	134-136	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	50-56
2337154-3	1990	Absolute rates of sodium reabsorption (TNa) in the surviving nephrons were increased with a lower ratio of TNa to oxygen consumption.	Oxygen	114-120	C-type lectin domain family 3, member B	Rattus norvegicus	39-42
2361889-0	1990	Factors affecting whole blood O2 transfer kinetics: implications for theta(O2).	Oxygen	30-32	immunoglobulin kappa variable 1D-39	Homo sapiens	69-77
6089877-10	1984	The bulk phase potentials in oxygen-limited, wild-type cells and in respiratory deficient (hem A) cells are comparable, but in the former the ATPase is poised for synthesis while in the latter it generates delta p.	Oxygen	29-35	ATPase	Escherichia coli	142-148
2108173-9	1990	Damage by active oxygen species, pressure overload, and derangements of protein synthesis is likely to include the causative factors of increased expression of c-fos and the hsp 70 gene family in postischemic reperfused liver.	Oxygen	17-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
8117850-0	1993	Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.	Oxygen	64-70	hemoglobin subunit gamma 2	Homo sapiens	106-119
8130494-1	1993	Automatic detection of arterial oxygen desaturations was investigated by collecting pulse oximeter saturation data through an MIB.	Oxygen	32-38	MIB E3 ubiquitin protein ligase 1	Homo sapiens	126-129
6589599-7	1984	NADPH does not seem to be essential for the enzymic conversion of H2O2 to O2 and water but does provide protection of catalase against inactivation by H2O2.	Oxygen	68-70	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
8443588-8	1993	Backbone amide protons of Phe4 and Ala13 and the backbone carbonyl oxygen of Lys2 that lie within this cleft appear to form hydrogen bonds with the guanosine O6 and N1H atoms, respectively.	Oxygen	67-73	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	77-81
2303440-8	1990	The conversion of xanthine dehydrogenase to the oxidase form may lead to a transient increase in the production of activated oxygen species.	Oxygen	125-131	xanthine dehydrogenase	Mus musculus	18-40
6704087-4	1984	The resolved flavoprotein, depleted of cytochrome b559, was reduced by NADPH under anaerobic conditions and reoxidized by oxygen.	Oxygen	122-128	mitochondrially encoded cytochrome b	Homo sapiens	39-51
2154454-5	1990	This nitroxide, which we have assigned as PBN/.OCH3, appears to be an oxygen-centered radical derived from the spin trapping of the reaction product of O2 and methyl radical.	Oxygen	70-76	spindlin 1	Homo sapiens	111-115
2154454-5	1990	This nitroxide, which we have assigned as PBN/.OCH3, appears to be an oxygen-centered radical derived from the spin trapping of the reaction product of O2 and methyl radical.	Oxygen	152-154	spindlin 1	Homo sapiens	111-115
2406899-7	1990	Increases in heart rate, respiratory rate, cardiac index, PaCO2 and oxygen delivery can therefore be expected during weaning from mechanical ventilation to spontaneous breathing with CPAP.	Oxygen	68-74	centromere protein J	Homo sapiens	183-187
1968295-3	1990	In nine 7-day-old rats, an acute focal hypoxic-ischemic insult produced by unilateral carotid artery ligation and subsequent exposure to 8% oxygen acutely reduced 3H-TCP binding ipsilateral to the ligation by 30% in the CA1, by 27% in the CA3, by 26% in the dentate gyrus, and by 17% in the striatum compared with values from the contralateral hemisphere.	Oxygen	140-146	carbonic anhydrase 3	Rattus norvegicus	239-242
2176907-4	1990	In mature PMN and MN phagocytes, regardless of the stimulating agent, the O2- production is closely related to Cyt b but not to MPO specific contents.	Oxygen	74-76	mitochondrially encoded cytochrome b	Homo sapiens	111-116
2136863-1	1990	To test the hypothesis that chronic infusion of atrial natriuretic peptide (ANP) instituted before hypoxic exposure attenuates the development of pulmonary hypertension in hypoxia adapted rats, ANP (0.2 and 1.0 microgram/h) or vehicle was administered intravenously via osmotic minipump for 4 wk beginning before exposure to 10% O2 or to room air.	Oxygen	329-331	natriuretic peptide A	Rattus norvegicus	48-74
1966816-4	1990	These data suggest that in immune complex-induced tissue damage in which neutrophils and their oxygen radicals and proteases play a key role, there is an interplay of PAF and neutrophils required for the full expression of injury.	Oxygen	95-101	PCNA clamp associated factor	Rattus norvegicus	167-170
2089623-7	1990	Comparison of the arterial and mixed venous data confirms the accuracy of the Oxygen Status Algorithm for calculating the various oxygen parameters, including the p50, the estimated 2,3-diphosphoglycerate concentration, and the estimated physiological shunt, on the basis of a single arterial blood sample.	Oxygen	78-84	activating signal cointegrator 1 complex subunit 1	Homo sapiens	163-166
2128557-1	1990	The new generation of very accurate multi-wavelength oximeters, e.g. OSM3, for in vitro measurement of the hemoglobin oxygen saturation, total hemoglobin concentration, and carboxy- and methemoglobin fractions opens new aspects of oxygen monitoring.	Oxygen	118-124	kinesin family member 17	Homo sapiens	69-73
2128557-1	1990	The new generation of very accurate multi-wavelength oximeters, e.g. OSM3, for in vitro measurement of the hemoglobin oxygen saturation, total hemoglobin concentration, and carboxy- and methemoglobin fractions opens new aspects of oxygen monitoring.	Oxygen	231-237	kinesin family member 17	Homo sapiens	69-73
33942194-10	2021	In acute brain slices of the rat cerebral cortex, activation of GLP-1R with an agonist Exendin-4 had a strong dilatory effect on cortical arterioles and effectively reversed arteriolar constrictions induced by metabolite lactate or oxygen and glucose deprivation, as an ex vivo model of ischaemic stroke.	Oxygen	232-238	glucagon-like peptide 1 receptor	Rattus norvegicus	64-70
33787215-0	2021	Tuning the Spin Density of Cobalt Single-Atom Catalysts for Efficient Oxygen Evolution.	Oxygen	70-76	spindlin 1	Homo sapiens	11-15
33787215-3	2021	Here, we synthesized ferromagnetic single Co atom catalysts on TaS2 monolayers (Co1/TaS2) as a model system to explore the spin-activity correlation for the oxygen evolution reaction (OER).	Oxygen	157-163	spindlin 1	Homo sapiens	123-127
33940849-5	2021	First, the extent of the Me1-surface oxygen (Me1-O) bond relaxation during CO adsorption played a key role.	Oxygen	37-43	malic enzyme 1	Homo sapiens	25-28
33940849-5	2021	First, the extent of the Me1-surface oxygen (Me1-O) bond relaxation during CO adsorption played a key role.	Oxygen	37-43	malic enzyme 1	Homo sapiens	45-48
33769053-0	2021	Oxidative alpha-C-C Bond Cleavage of 2  and 3  Alcohols to Aromatic Acids with O2 at Room Temperature via Iron Photocatalysis.	Oxygen	79-81	acetyl-CoA carboxylase alpha	Homo sapiens	10-19
33768096-6	2021	We found that activation of AMPK improved mitochondrial oxidative phosphorylation (OxPhos) and the oxygen consumption rate (OCR).	Oxygen	99-105	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	28-32
33814763-12	2021	Based on ROC analysis a score of 4 for OS1, 9 for OS2 and 12.7% for OP was determined as the cut off for oxygen requirement.	Oxygen	105-111	frizzled related protein	Homo sapiens	39-42
31626532-2	2019	The M centers of the mononuclear monooxygenases peptidylglycine monooxygenase (PHM) and dopamine beta-monooxygenase bind and activate dioxygen en route to substrate hydroxylation.	Oxygen	134-142	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	79-82
31626532-4	2019	The PHM M site exhibits a number of unusual attributes, including a His2Met ligand set, a fluxional Cu(I)-S(Met) bond, tight binding of exogenous ligands CO and N3-, and complete coupling of oxygen reduction to substrate hydroxylation even at extremely low turnover rates.	Oxygen	191-197	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	4-7
26628974-0	2015	Effect of hyperbaric oxygen on MMP9/2 expression and motor function in rats with spinal cord injury.	Oxygen	21-27	matrix metallopeptidase 9	Rattus norvegicus	31-35
26628974-9	2015	At 72 h after modeling, compared with spinal cord injury group, MMP9/2 gene and protein expression in hyperbaric oxygen group was significantly lower (P &lt; 0.05).	Oxygen	113-119	matrix metallopeptidase 9	Rattus norvegicus	64-70
26628974-12	2015	Hyperbaric oxygen therapy played a protective effect on spinal cord injury through reducing apoptosis of neuronal cells and expression of MMP9/2 gene and protein in rats with spinal cord injury.	Oxygen	11-17	matrix metallopeptidase 9	Rattus norvegicus	138-144
11978492-7	2002	Some antioxidant enzymes were also analyzed in RBCs, including glucose-6-phosphate dehydrogenase (G6PD), which provides the RBC"s main reducing power, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and catalase detoxifies H2O2 by catalyzing its reduction to O2 and H2O.	Oxygen	238-240	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
10970068-1	2000	Oxygen insensitivity of cancer cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) activity enables detection of cancer cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	0-6	glucose-6-phosphate dehydrogenase	Homo sapiens	110-143
10970068-1	2000	Oxygen insensitivity of cancer cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) activity enables detection of cancer cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	0-6	glucose-6-phosphate dehydrogenase	Homo sapiens	145-149
10970068-1	2000	Oxygen insensitivity of cancer cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) activity enables detection of cancer cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	41-47	glucose-6-phosphate dehydrogenase	Homo sapiens	110-143
10970068-1	2000	Oxygen insensitivity of cancer cells and oxygen sensitivity of non-cancer cells in the histochemical assay of glucose-6-phosphate dehydrogenase (G6PD) activity enables detection of cancer cells in unfixed cell smears or cryostat sections of biopsies.	Oxygen	41-47	glucose-6-phosphate dehydrogenase	Homo sapiens	145-149
34600384-6	2022	The oxidation of Cr3+ to Cr6+ in the presence of alkaline substances has been elucidated by density functional theory, and it is revealed that the electrons from the Cr-d orbit jump to the Ca-d and directly transform into the O2.	Oxygen	226-228	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	25-28
34666223-2	2022	We therefore examined physiologically relevant dynamic changes in glucose levels based on glucose metabolism and production during aerobic culture (10% O2) of rat primary hepatocytes stimulated with insulin or glucagon on a highly O2 permeable plate, which can maintain the oxygen concentration close to the periportal zone of the liver.	Oxygen	231-233	glucagon	Rattus norvegicus	210-218
34666223-2	2022	We therefore examined physiologically relevant dynamic changes in glucose levels based on glucose metabolism and production during aerobic culture (10% O2) of rat primary hepatocytes stimulated with insulin or glucagon on a highly O2 permeable plate, which can maintain the oxygen concentration close to the periportal zone of the liver.	Oxygen	274-280	glucagon	Rattus norvegicus	210-218
34813893-9	2022	In summary, our data implicates that SUCNR1 is crucial for Gln-addicted cancer cells by limiting TCA cycle throughput, mitochondrial respiration and the production of reactive oxygen species, highlighting its potential as a pharmacological target for cancer treatment.	Oxygen	176-182	succinate receptor 1	Homo sapiens	37-43
34896479-3	2022	In this study, we found that the transcriptional and translational levels of ZFP36 were increased in immortalized hippocampal HT22 neuronal cells after oxygen-glucose deprivation/reoxygenation (OGD/R) treatment.	Oxygen	152-158	zinc finger protein 36	Mus musculus	77-82
1339619-2	1992	ACE in captopril group was significant reduced P &lt; 0.05 (58.4 +/- to 27.0 +/- 3.0 mumol.min-1/L), but in nitrendipine group was not markedly changed (P &gt; 0.05), we found that reducing the degree of PAP and its duration time, lowered the pulmonary vascular resistance (PVR) and right ventricle stroke index (RVSWI), also improved capacity of oxygen delivery.	Oxygen	347-353	angiotensin-converting enzyme	Sus scrofa	0-3
1328390-8	1992	Thus, ACT may have an important role in regulation of specific aspects of the inflammatory processes and the modulation of toxic oxygen-based host tissue damage.	Oxygen	129-135	serpin family A member 3	Homo sapiens	6-9
1327161-5	1992	Elastin oxidation by 2:1 PQQ/Cu(II) required aerobic conditions consistent with oxygen-dependent turnover of this catalytic pair.	Oxygen	80-86	elastin	Homo sapiens	0-7
1390940-1	1992	Hemoglobin Dallas, an alpha-chain variant with a substitution of lysine for asparagine at position 97(G4), was found to have increased oxygen affinity (p1/2 = 1 mmHg at pH 7.3 and 20 degrees C), diminished cooperativity (n, the Hill coefficient = 1.7) and reduced Bohr effect (about 50%).	Oxygen	135-141	crystallin gamma F, pseudogene	Homo sapiens	152-160
1448112-2	1992	Peptidylglycine alpha-hydroxylating monooxygenase (PHM) catalyzes the first step of the reaction and is dependent on copper, ascorbate, and molecular oxygen.	Oxygen	40-46	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	51-54
1415559-5	1992	In this study, we investigated the kinetics of mRNA, specific (immunoreactive) proteins, and enzyme activities of pulmonary Mn SOD and Cu,Zn SOD in IL-1-induced O2-tolerant rats.	Oxygen	161-163	superoxide dismutase 2	Rattus norvegicus	124-130
1324665-2	1992	The O2- production by the oxidase reconstituted in vitro with the crude membrane fraction is enhanced several-fold by addition of FAD, whereas that with the partially purified cytochrome is completely dependent on exogenous FAD, suggesting that FAD acts through the membrane component, cytochrome b558.	Oxygen	4-6	mitochondrially encoded cytochrome b	Homo sapiens	286-298
1635086-9	1992	Oxygen consumption studies showed that xanthine dehydrogenase-activated mitomycin C consumed oxygen at a much lower rate than xanthine oxidase-activated mitomycin C.	Oxygen	0-6	xanthine dehydrogenase	Mus musculus	39-61
1635086-9	1992	Oxygen consumption studies showed that xanthine dehydrogenase-activated mitomycin C consumed oxygen at a much lower rate than xanthine oxidase-activated mitomycin C.	Oxygen	0-6	xanthine dehydrogenase	Mus musculus	126-142
1635086-9	1992	Oxygen consumption studies showed that xanthine dehydrogenase-activated mitomycin C consumed oxygen at a much lower rate than xanthine oxidase-activated mitomycin C.	Oxygen	93-99	xanthine dehydrogenase	Mus musculus	39-61
1618916-11	1992	Thus, it is possible to spectroscopically dissect and image the substrate (NADPH) and product (O2-) reactions of the NADPH oxidase in living unlabeled neutrophils.	Oxygen	95-97	2,4-dienoyl-CoA reductase 1	Homo sapiens	117-122
1404411-1	1992	Myoglobin is known to protect the mechanical function of the heart from hypoxia by acting as a sarcoplasmic oxygen reservoir and shuttle.	Oxygen	108-114	myoglobin	Canis lupus familiaris	0-9
1588959-2	1992	Expression of HEM13 is repressed by oxygen and heme.	Oxygen	36-42	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	14-19
1630627-3	1992	Exposure of conscious young animals to heat at 38 degrees C for 4 h in a biological oxygen demand incubator resulted in a marked increase of the GFAP immunoreactivity in specific brain regions as compared with the intact controls.	Oxygen	84-90	glial fibrillary acidic protein	Rattus norvegicus	145-149
1581313-6	1992	Oxygen evolution rates of 115-140 mumol of O2 (mg of Chl)-1 h-1 were observed in the NaCl-urea-washed preparations.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	43-63
1590406-8	1992	During more severe oxygen deprivation (anoxia), neurons also depolarized at different rates with XII greater than DMNX greater than CA1.	Oxygen	19-25	carbonic anhydrase 1	Homo sapiens	132-135
1567225-0	1992	The contribution of vascular endothelial xanthine dehydrogenase/oxidase to oxygen-mediated cell injury.	Oxygen	75-81	xanthine dehydrogenase	Bos taurus	41-71
1567225-1	1992	The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the reaction of XO-derived partially reduced oxygen species (PROS) have been suggested to be important in diverse mechanisms of tissue pathophysiology, including oxygen toxicity.	Oxygen	121-127	xanthine dehydrogenase	Bos taurus	18-40
1567225-1	1992	The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the reaction of XO-derived partially reduced oxygen species (PROS) have been suggested to be important in diverse mechanisms of tissue pathophysiology, including oxygen toxicity.	Oxygen	121-127	xanthine dehydrogenase	Bos taurus	42-45
1567225-5	1992	Cell XDH+XO activity decreased 98% after 48 h of 95% O2 exposure and decreased 68% after 48 h normoxia.	Oxygen	53-55	xanthine dehydrogenase	Bos taurus	5-8
1427427-0	1992	Molecular characterization and functional studies on Hb Kempsey, beta 99 (G-1) Asp----Asn, a high-oxygen affinity variant.	Oxygen	98-104	proline rich protein BstNI subfamily 3	Homo sapiens	65-77
1569852-5	1992	Cross-modal comparisons suggested an average overall RPE of close to 13 units at 70% of a task and environment-specific peak oxygen intake, irrespective of exercise conditions, but the SD of individual responses varied by at least +/- 2 units about this average.	Oxygen	125-131	ribulose-5-phosphate-3-epimerase	Homo sapiens	53-56
1312809-4	1992	The oxygen burst induced by FMLP or OZ was inhibited by genistein and alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamid (ST638), which are inhibitors of tyrosine kinase (TK), and was enhanced by 1-(5-isoquinoline-sulfonyl)-3-methyl-piperazine (H-7) and staurosporine, which are inhibitors of protein kinase C (PKC).	Oxygen	4-10	TXK tyrosine kinase	Homo sapiens	163-178
1312809-4	1992	The oxygen burst induced by FMLP or OZ was inhibited by genistein and alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamid (ST638), which are inhibitors of tyrosine kinase (TK), and was enhanced by 1-(5-isoquinoline-sulfonyl)-3-methyl-piperazine (H-7) and staurosporine, which are inhibitors of protein kinase C (PKC).	Oxygen	4-10	TXK tyrosine kinase	Homo sapiens	180-182
1385579-3	1992	Two hypotheses have been offered as possible explanations of the death of photoreceptor cells in this disorder: (1) photoreceptors are starved for amino acids, retinal, oxygen, etc; and (2) that IRBP levels and synthesis may be decreased and interfere with retinal transport and this deficiency is lethal to these cells.	Oxygen	169-175	retinol binding protein 3	Rattus norvegicus	195-199
1554747-6	1992	In both cell types, hypoxia (0% O2) significantly reduced the amount of ET-1 at 48 h. Restoration of normoxia in 21% O2 for 48 h resulted in a return of ET-1 levels to baseline.	Oxygen	117-119	endothelin 1	Bos taurus	153-157
1311166-2	1992	Under pure oxygen, the spin adduct PBN/.OCH3 was rapidly generated by the addition of Fe2+ (0.2-1.2 mM) into phosphate buffer containing ethylenediaminetetraacetate (EDTA), dimethyl sulfoxide, and PBN at pH 7.4, but it decayed.	Oxygen	11-17	spindlin 1	Homo sapiens	23-27
1315607-4	1992	Presynaptic [Ca2+]o responses were rapidly and reversibly suppressed when oxygen was withdrawn from hippocampal tissue slices.	Oxygen	74-80	carbonic anhydrase 2	Homo sapiens	13-16
1456503-7	1992	ABL 510 measures simultaneously oxygen saturation by spectrophotometry.	Oxygen	32-38	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-3
1510372-1	1992	The anatomical and metabolic deterioration of the dopaminergic (DA) nigrostriatal system with age has been hypothesized to occur due to autodestruction by reactive oxygen intermediates derived from oxidative metabolites of DA.	Oxygen	164-170	renin binding protein	Rattus norvegicus	94-97
1727639-6	1992	These results support the conclusion that in H2O2-resistant cells, catalase activity is a major determinant of cellular resistance to H2O2 toxicity, whereas catalase activity has a limited role in cellular resistance to an acute exposure to 95% O2 and is unrelated to cellular resistance to 4-hydroxy-2-nonenal.	Oxygen	47-49	catalase	Cricetulus griseus	67-75
1374349-5	1992	A rapid determination of HbF percentage, using OSM3, is an important determinant for correct assessment of oxygen saturation in newborn infants in intensive care units.	Oxygen	107-113	kinesin family member 17	Homo sapiens	47-51
34500168-6	2022	As an electrocatalyst, Mo-NiCo2O4/NF shows a rapid self-reconstruction process during oxygen evolution reaction (OER) that produces rich oxygen vacancies and thus exhibits remarkable long-term stability.	Oxygen	86-92	neurofascin	Homo sapiens	34-36
34500168-6	2022	As an electrocatalyst, Mo-NiCo2O4/NF shows a rapid self-reconstruction process during oxygen evolution reaction (OER) that produces rich oxygen vacancies and thus exhibits remarkable long-term stability.	Oxygen	137-143	neurofascin	Homo sapiens	34-36
34798156-3	2022	In tumor microenvironment (TME), MnO2 nanosheets on the surface of mesoporous polydopamine (MPDA) could react with endogenous hydrogen peroxide (H2O2) and generate oxygen (O2) to relieve tumor hypoxia, thus enhancing the efficacy of PDT and GOx catalysis.	Oxygen	164-170	hydroxyacid oxidase 1	Homo sapiens	241-244
34798156-3	2022	In tumor microenvironment (TME), MnO2 nanosheets on the surface of mesoporous polydopamine (MPDA) could react with endogenous hydrogen peroxide (H2O2) and generate oxygen (O2) to relieve tumor hypoxia, thus enhancing the efficacy of PDT and GOx catalysis.	Oxygen	172-174	hydroxyacid oxidase 1	Homo sapiens	241-244
34798156-4	2022	Glucose consumption under the catalysis of GOx will enhance the acidity of TME and increase intracellular H2O2 concentration, which in turn promotes the production of O2 by MnO2 nanosheets, thus forming efficient cascade reaction and maximizing the efficacy of the functional agents.	Oxygen	167-169	hydroxyacid oxidase 1	Homo sapiens	43-46
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	CREB binding protein	Mus musculus	285-305
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	CREB binding protein	Mus musculus	307-310
34921706-0	2022	Spin-State Manipulation of Two-Dimensional Metal-Organic Framework with Enhanced Metal-Oxygen Covalency for Lithium-Oxygen Batteries.	Oxygen	87-93	spindlin 1	Homo sapiens	0-4
34921706-0	2022	Spin-State Manipulation of Two-Dimensional Metal-Organic Framework with Enhanced Metal-Oxygen Covalency for Lithium-Oxygen Batteries.	Oxygen	116-122	spindlin 1	Homo sapiens	0-4
34921706-3	2022	The spin-state modulation enables enhanced nickel-oxygen covalency in Ni III -NCF, which facilitates electron exchange between the Ni sites and oxygen adsorbates and accelerates the oxygen redox kinetics.	Oxygen	50-56	spindlin 1	Homo sapiens	4-8
34921706-3	2022	The spin-state modulation enables enhanced nickel-oxygen covalency in Ni III -NCF, which facilitates electron exchange between the Ni sites and oxygen adsorbates and accelerates the oxygen redox kinetics.	Oxygen	144-150	spindlin 1	Homo sapiens	4-8
34921706-3	2022	The spin-state modulation enables enhanced nickel-oxygen covalency in Ni III -NCF, which facilitates electron exchange between the Ni sites and oxygen adsorbates and accelerates the oxygen redox kinetics.	Oxygen	182-188	spindlin 1	Homo sapiens	4-8
1334036-2	1992	Release of oxygen-derived radicals is one of the important and relevant actions of PAF.	Oxygen	11-17	PCNA clamp associated factor	Rattus norvegicus	83-86
1334036-14	1992	Therefore, PAF is a key mediator that can directly enhance the release of toxic oxygen-derived radicals which may contribute to organ failure during endotoxemia or sepsis.	Oxygen	80-86	PCNA clamp associated factor	Rattus norvegicus	11-14
1657601-8	1991	Genetic defects in the cytochrome b subunits and in the cytosolic factors have been shown to be the molecular basis of chronic granulomatous disease, a group of inherited disorders in the host defense, characterized by severe, recurrent bacterial and fungal infections in which phagocytic cells fail to generate O2- upon stimulation.	Oxygen	312-314	mitochondrially encoded cytochrome b	Homo sapiens	23-35
6704087-9	1984	The dithionite reduced form of the resolved cytochrome b559 was rapidly oxidized by oxygen, as was the cytochrome b559 in the intact oxidase.	Oxygen	84-90	mitochondrially encoded cytochrome b	Homo sapiens	44-56
1766349-3	1991	Oxygen uptake (VO2) responses were significantly more pronounced in direct relationship to the bench height: B-12 greater than B-10 greater than B-8 greater than B-6 (P less than 0.05).	Oxygen	0-6	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	127-131
34794563-8	2021	The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added.	Oxygen	127-129	tyrosinase	Homo sapiens	4-7
6704087-9	1984	The dithionite reduced form of the resolved cytochrome b559 was rapidly oxidized by oxygen, as was the cytochrome b559 in the intact oxidase.	Oxygen	84-90	mitochondrially encoded cytochrome b	Homo sapiens	103-115
34794563-8	2021	The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added.	Oxygen	127-129	tyrosinase	Homo sapiens	264-267
6437167-1	1984	Oxygen, oxidizing enzymes such as polyphenol oxidase (tyrosinase) and alkaline pH, irreversibly inactivate the mutagenicity of quercetin in the Ames test.	Oxygen	0-6	tyrosinase	Homo sapiens	54-64
34903226-3	2021	RESULTS: We successfully fabricated the O2 economizer (HMME@HMONs-3BP-PEG, HHBP) via conjugation of respiration inhibitor 3-bromopyruvate (3BP) with hollow mesoporous organosilica nanoparticles (HMONs), followed by the loading of organic sonosensitizers (hematoporphyrin monomethyl ether; HMME) and further surface modification of poly(ethylene glycol) (PEG).	Oxygen	40-42	azurocidin 1	Homo sapiens	75-79
34903226-7	2021	As a result, when accompanied with suppressing O2-consumption and triggering pro-death autophagy strategy, the HHBP could achieve the remarkable antitumor activity, which was systematically validated both in vivo and in vitro assays.	Oxygen	47-50	azurocidin 1	Homo sapiens	111-115
1755337-1	1991	Some mechanisms to reduce methemoglobin (metHb) formation for the maintenance of normal oxygen transport have been proposed.	Oxygen	88-94	hemoglobin subunit gamma 2	Homo sapiens	26-39
6419199-3	1984	We have overemphasized the role of oxygen in the past, and as a result of this the false impression has been created that RLF is a disease that can be prevented.	Oxygen	35-41	RLF zinc finger	Homo sapiens	122-125
1791237-0	1991	Differential oxygen sensitivities in G6PDH activities of cultured keloid and normal skin dermis single cells.	Oxygen	13-19	glucose-6-phosphate dehydrogenase	Homo sapiens	37-42
1791237-4	1991	Differential oxygen sensitivity in G6PDH activities between malignant and non-malignant cells have been reported, but its occurrence between keloid and normal skin cells is novel, especially as the keloid is regarded as a benign tumor with a zero carcinogenicity rate.	Oxygen	13-19	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
1716537-4	1991	The error in pulse oximetry caused by the presence of carboxyhemoglobin is insubstantial, but methemoglobin gives either an understimation or an overestimation at high or low oxygen saturation, respectively, the turning point being near 70% saturation.	Oxygen	175-181	hemoglobin subunit gamma 2	Homo sapiens	94-107
34876189-9	2021	The activity of fat metabolism-related enzymes, ATGL, HSL, and MGL increased under hypothermia and low oxygen conditions.	Oxygen	103-109	C-type lectin domain containing 10A	Rattus norvegicus	63-66
6317733-1	1983	A chemiluminescent method for measuring the concentration of activated oxygen species (O-2 and H2O2) is described.	Oxygen	71-77	immunoglobulin kappa variable 1D-39	Homo sapiens	87-90
34855884-7	2021	We hypothesized that the activation of TrkB receptor protects retinal vasculature in the mice during oxygen-induced ischemic retinopathy (OIR), a model of ROP.	Oxygen	101-107	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	39-43
1652787-3	1991	Cytochalasin B (cyt B) pretreatment affected the production of O2- by exudate cells, although to a lesser extent than the production by peripheral blood cells, in which a substantial increase was induced.	Oxygen	63-65	mitochondrially encoded cytochrome b	Homo sapiens	16-21
6885792-6	1983	The known inactivation of methemoglobin by phenylhydrazine is shown to depend on H2O2 but not oxygen.	Oxygen	94-100	hemoglobin subunit gamma 2	Homo sapiens	26-39
1859066-4	1991	In the first part, constant-flow insufflation of oxygen (CFI) was used in seven patients ventilated for acute respiratory failure (PaO2/FlO2 = 347 +/- 33 mm Hg) as a means of maintaining arterial oxygenation during apnea and disconnection from the ventilator.	Oxygen	49-55	complement factor I	Homo sapiens	57-60
1859066-6	1991	In comparison to apnea alone, CFI prevented a fall in arterial oxygen tension (16 +/- 7 mm Hg during CFI versus 117 +/- 27 during apnea, after 90 s of disconnection in the two situations, p less than 0.001), whereas it did not reduce the development of hypercapnia.	Oxygen	63-69	complement factor I	Homo sapiens	30-33
1859066-7	1991	The efficacy of CFI resulted both from the injection of oxygen into the trachea and from the maintenance of positive alveolar pressure induced by air entrainment (mean 10.4 +/- 1.1 cm H2O), preventing a fall in lung volume usually occurring after disconnection (+338 +/- 88 ml during CFI versus -344 +/- 64 ml during apnea, p less than 0.01).	Oxygen	56-62	complement factor I	Homo sapiens	16-19
1859066-8	1991	In the second part of the study CFI was used to prevent arterial oxygen desaturation induced by endotracheal suctioning.	Oxygen	65-71	complement factor I	Homo sapiens	32-35
1910309-1	1991	The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1, 2-benzoquinone (o-dopaminequinone), which evolves nonenzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium.	Oxygen	61-63	tyrosinase	Homo sapiens	77-87
1649821-5	1991	As indicated by measurement of oxygen consumption, the purified cytochrome catalytically reduced oxygen at a rate equal to approximately 30% of the activity of the phorbol myristate acetate-activated cells on the basis of cytochrome b558 content.	Oxygen	97-103	cytochrome b, mitochondrial	Rattus norvegicus	222-234
2029516-1	1991	Overall association and dissociation rate constants were measured at 20 degrees C for O2, CO, and alkyl isocyanide binding to position 45 (CD3) mutants of pig and sperm whale myoglobins and to sperm whale myoglobin reconstituted with protoheme IX dimethyl ester.	Oxygen	86-88	CD3 epsilon subunit of T-cell receptor complex	Sus scrofa	139-142
2029516-7	1991	However, the rates of geminate recombination of NO and O2 and the affinity of myoglobin for O2 were dependent upon the basicity of residue 45.	Oxygen	92-94	myoglobin	Sus scrofa	78-87
2029516-8	1991	The series of substitutions Arg45, Lys45, Ser45, and Glu45 in pig myoglobin led to a 3-fold decrease in the initial rate for the intramolecular, picosecond rebinding of NO and 4-fold decrease in the geminate rate constant for the nanosecond rebinding of O2.	Oxygen	254-256	myoglobin	Sus scrofa	66-75
1879209-3	1991	Results showed that Ginsenoside Rb1 and Rg1 could inhibit lipid peroxidation of rat liver and brain microsomes and that Rb1, at the final concentration of 10(-4)-10(-3) mol/L, could scavenge O2-.	Oxygen	191-193	RB transcriptional corepressor 1	Rattus norvegicus	120-123
1902227-3	1991	The NH2-terminal third of the PAM precursor contains the first enzyme, peptidylglycine alpha-hydroxylating monooxygenase (PHM), a copper, molecular oxygen, and ascorbate-dependent enzyme.	Oxygen	111-117	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	122-125
2034994-10	1991	A good correlation was demonstrated between PO2vac and PO2tono, the correlation coefficient being 0.8619, confirming that the suction-fixed oxygen electrode measures tissue oxygen.	Oxygen	140-146	PO2	Sus scrofa	44-47
2034994-10	1991	A good correlation was demonstrated between PO2vac and PO2tono, the correlation coefficient being 0.8619, confirming that the suction-fixed oxygen electrode measures tissue oxygen.	Oxygen	173-179	PO2	Sus scrofa	44-47
1652586-8	1991	In this respiratory system, an electron equivalent is probably transferred through the mitochondrial respiratory chain between cytochrome b and cytochrome c and finally to molecular oxygen in the reaction catalyzed by the CO-insensitive terminal oxidase.	Oxygen	182-188	CYTB	Urechis unicinctus	127-139
1988282-4	1991	Results showed that in chondrocytes, c-myc and c-Ha-ras expression was particularly important during the G1 phase of the cell cycle and that oxygen reactive species, especially H2O2, induced an important decrease of c-myc and c-Ha-ras mRNA levels.	Oxygen	141-147	myc proto-oncogene protein	Oryctolagus cuniculus	216-221
2019483-6	1991	Oxygen breathing at 1 ATA significantly reduced TR1/2 (p less than 0.05) and at 2 ATA significantly reduced TR1/2 and TR (p less than 0.005 and p less than 0.0001) compared with control measurements during air breathing at 1 ATA.	Oxygen	0-6	thioredoxin reductase 1	Homo sapiens	48-53
2019483-6	1991	Oxygen breathing at 1 ATA significantly reduced TR1/2 (p less than 0.05) and at 2 ATA significantly reduced TR1/2 and TR (p less than 0.005 and p less than 0.0001) compared with control measurements during air breathing at 1 ATA.	Oxygen	0-6	thioredoxin reductase 1	Homo sapiens	108-120
1828766-5	1991	The greater decrease in coronary resistance, and the lowering of coronary oxygen extraction, suggest that ANF has a small coronary dilating effect.	Oxygen	74-80	natriuretic peptide A	Rattus norvegicus	106-109
1988069-13	1991	Adult animals exposed to hyperoxia (95% oxygen) showed a 3-fold increase in hepatic hemopexin mRNA content.	Oxygen	40-46	hemopexin	Rattus norvegicus	84-93
1828004-10	1991	The strongly dipolarized carbonyl group in the acyclic keto forms of 1 and 2 appears to stabilize chain conformations having O-1 and O-3 eclipsed with the carbonyl oxygen.	Oxygen	164-170	immunoglobulin kappa variable 2D-40	Homo sapiens	125-136
1846161-7	1991	O2- formation occurred in neutrophils incubated with Staphylococcus aureus cell walls bearing antibodies to Fc gamma RII or Fc gamma RIII.	Oxygen	0-2	Fc gamma receptor IIIa	Homo sapiens	124-137
1767627-2	1991	Our data show a decrease in arterial oxygen saturation after CPT and after 2h monitoring; the lateral position results in a better SaO2 in the pneumonia group while SaO2 tend to decrease in the control population.	Oxygen	37-43	choline phosphotransferase 1	Homo sapiens	61-64
1832909-2	1991	G6PD activities were measured under atmospheres of both N2 and O2.	Oxygen	63-65	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
1654602-6	1991	Two components of the monooxygenase system responsible for BP metabolism, cytochrome P-450 and NADPH-cytochrome P-450 reductase, are also inhibited by the two oxygen metabolites in a similar manner.	Oxygen	26-32	cytochrome p450 oxidoreductase	Rattus norvegicus	95-127
2260678-8	1990	The results suggest that the increased pulmonary Mn-SOD in TNF-insufflated rats may contribute to the TNF-induced protection against oxygen toxicity.	Oxygen	133-139	superoxide dismutase 2	Rattus norvegicus	49-55
2125208-2	1990	Tyrosinase catalyses the oxidation by molecular oxygen of alpha-methyldopa to o-alpha-methyldopaquinone, which evolves non-enzymically through a branched pathway with cyclization or hydroxylation reactions.	Oxygen	48-54	tyrosinase	Homo sapiens	0-10
2229778-6	1990	Endothelin-1 in doses of 10 to 30 pmol/kg produced electrocardiographic ST segment elevation associated with decreased oxygen saturation of coronary sinus venous blood.	Oxygen	119-125	endothelin-1	Sus scrofa	0-12
34787393-3	2021	The aAPCs, termed CD-MnOx@CM, not only efficiently enhanced the expansion and activation of intratumoral CD8+ cytotoxic T-cells and dendritic cells after homing to homotypic metastatic tumors but also regulated the TME to facilitate T-cell survival through catalyzing the decomposition of intratumoral H2O2 into O2.	Oxygen	312-314	CD8a molecule	Homo sapiens	105-108
34491608-6	2021	Mercury treatment did not modify systolic blood pressure (SBP), but increased vascular reactivity due to the reduction of nitric oxide bioavailability associated with the increase in reactive oxygen species from endothelial nitric oxide synthase (eNOS) uncoupling.	Oxygen	192-198	nitric oxide synthase 3	Rattus norvegicus	212-245
34491608-6	2021	Mercury treatment did not modify systolic blood pressure (SBP), but increased vascular reactivity due to the reduction of nitric oxide bioavailability associated with the increase in reactive oxygen species from endothelial nitric oxide synthase (eNOS) uncoupling.	Oxygen	192-198	nitric oxide synthase 3	Rattus norvegicus	247-251
34288826-12	2021	The expression of miR-106b-5p was lower in oxygen and glucose deprivation hemin-treated (OGD/H-treated) cells.	Oxygen	43-49	microRNA 106b	Homo sapiens	18-26
34741187-1	2021	Mitogen-activated protein kinase (MAPK) signalling pathways are crucial for developmental processes, oncogenesis, and inflammation, including the production of proinflammatory cytokines caused by reactive oxygen species and upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.	Oxygen	205-211	mapk	None	34-38
34954904-7	2021	CEBPD promoted glucose uptake and lactate production by upregulating SLC2A1 and HK2, leading to mitochondrial fission, increased extracellular acidification rate and decreased oxygen consumption rate to fuel cell growth.	Oxygen	176-182	CCAAT enhancer binding protein delta	Homo sapiens	0-5
34954904-7	2021	CEBPD promoted glucose uptake and lactate production by upregulating SLC2A1 and HK2, leading to mitochondrial fission, increased extracellular acidification rate and decreased oxygen consumption rate to fuel cell growth.	Oxygen	176-182	solute carrier family 2 member 1	Homo sapiens	69-75
34396536-2	2021	In this study, the mechanism by which the interleukin (IL)-23/IL-17 axis regulates RNV in oxygen-induced retinopathy (OIR) model mice and in cell experiments in vitro was characterized.	Oxygen	90-96	interleukin 17A	Mus musculus	62-67
34379294-2	2021	Autophagy-related 3 (ATG3), an important autophagy regulator, was reported to be upregulated in a rat model of cerebral ischemia/reperfusion (CI/R) injury and an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model.	Oxygen	162-168	autophagy related 3	Rattus norvegicus	0-19
34379294-2	2021	Autophagy-related 3 (ATG3), an important autophagy regulator, was reported to be upregulated in a rat model of cerebral ischemia/reperfusion (CI/R) injury and an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model.	Oxygen	162-168	autophagy related 3	Rattus norvegicus	21-25
34517657-2	2021	Herein, an interrelated catalytic enzyme system has been developed, termed as CataFlower, which is composed of nanoflower MoS2 (peroxidase) decorated with GOx (glucose oxidase) and MnO2 (oxygen generator), and exhibits synergistic oxidative capability for sensitively monitoring sweat glucose.	Oxygen	187-193	hydroxyacid oxidase 1	Homo sapiens	160-175
34517657-3	2021	CataFlower can not only generate oxygen in situ to maximize GOx activity, but promote peroxidase-triggered H2O2 oxidation of methylene blue, resulting in sensitive colorimetric detection of glucose.	Oxygen	33-39	hydroxyacid oxidase 1	Homo sapiens	60-63
34842057-5	2021	CONCLUSION: Serum SCUBE1 levels increased more in male patients with severe OSA compared to other OSA levels, and high serum SCUBE1 levels were found to be associated with lower oxygen levels in OSA patients.	Oxygen	178-184	signal peptide, CUB domain and EGF like domain containing 1	Homo sapiens	125-131
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	small nucleolar RNA host gene 15	Homo sapiens	58-64
34868528-12	2021	In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased.	Oxygen	7-13	sirtuin 1	Homo sapiens	117-122
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	small nucleolar RNA host gene 15	Homo sapiens	7-13
34868528-13	2021	In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group.	Oxygen	32-38	sirtuin 1	Homo sapiens	118-123
34757363-4	2021	Overexpression of CXCR4 facilitated improved cellular internalization of cGNPs and irradiation of internalized cGNPs resulted in more unrepaired DNA double strand breaks and increased the production of oxygen free radicals compared to irradiation with non-internalized pGNPs.	Oxygen	202-208	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
34946824-2	2021	rHuEPO, like endogenous EPO, increases arterial oxygen content and thus aerobic power.	Oxygen	48-54	erythropoietin	Equus caballus	24-27
34940412-4	2021	The results of the MBR-MBfR experiments indicated that a C/N ratio of two was suitable for NH4+-N, NO2--N, NO3--N, and chemical oxygen demand (COD) removal in partial nitrification-denitrification (PN-D) and hydrogen autotrophic denitrification for further treatment.	Oxygen	128-134	translocator protein	Homo sapiens	19-22
34868007-8	2021	Downregulation of two major transcriptional factors, early growth response gene (Egr)-2 and growth factor independence 1 (Gfi1), were identified to play a role in the exaggerated pro-inflammatory response of preterm MF to LPS insult after priming with 65% or 3% O2.	Oxygen	262-264	growth factor independent 1 transcriptional repressor	Homo sapiens	92-120
34868007-8	2021	Downregulation of two major transcriptional factors, early growth response gene (Egr)-2 and growth factor independence 1 (Gfi1), were identified to play a role in the exaggerated pro-inflammatory response of preterm MF to LPS insult after priming with 65% or 3% O2.	Oxygen	262-264	growth factor independent 1 transcriptional repressor	Homo sapiens	122-126
34831423-5	2021	Indeed, the NGB capability to reversibly bind oxygen and its neuroprotective function against several types of insults including oxidative stress, ischemia, and neurodegenerative conditions have raised the interest in the possible role of the globin as oxygen supplier in the retina and as a target for retinal neurodegeneration.	Oxygen	46-52	neuroglobin	Homo sapiens	12-15
34139662-9	2021	The sensing mechanism was revealed as a dynamic collision between Ir(ppy)2(Ln) and O2 molecules.	Oxygen	83-85	pancreatic polypeptide 2, pseudogene	Homo sapiens	66-74
34606937-6	2021	Furthermore, the hydrogen peroxide generated by GOx as well as overexpressed in tumor can be decomposed by CAT and continuously generate oxygen, which further enhance the efficacy of oxygen-dependent starvation therapy and photodynamic therapy.	Oxygen	137-143	hydroxyacid oxidase 1	Homo sapiens	48-51
34738957-6	2022	RESULTS: Our results demonstrated that deltaPKC-dependent Drp1 activation is associated with increased mitochondrial fission, impaired cellular respiration, and increased mitochondrial reactive oxygen species in LPS-treated macrophages.	Oxygen	194-200	utrophin	Homo sapiens	58-62
34588219-4	2021	Detailed analysis shows that perilipin1 (plin1), a core gene involved in the regulation of LDs, is suppressed by the immune deficiency signaling, one major innate immune pathway in Drosophila During immune activation, downregulated plin1 promotes the enlargement of LDs, which in turn alleviates immune reaction-associated reactive oxygen species stress.	Oxygen	332-338	Lipid storage droplet-1	Drosophila melanogaster	29-39
34588219-4	2021	Detailed analysis shows that perilipin1 (plin1), a core gene involved in the regulation of LDs, is suppressed by the immune deficiency signaling, one major innate immune pathway in Drosophila During immune activation, downregulated plin1 promotes the enlargement of LDs, which in turn alleviates immune reaction-associated reactive oxygen species stress.	Oxygen	332-338	Lipid storage droplet-1	Drosophila melanogaster	41-46
34588219-4	2021	Detailed analysis shows that perilipin1 (plin1), a core gene involved in the regulation of LDs, is suppressed by the immune deficiency signaling, one major innate immune pathway in Drosophila During immune activation, downregulated plin1 promotes the enlargement of LDs, which in turn alleviates immune reaction-associated reactive oxygen species stress.	Oxygen	332-338	Lipid storage droplet-1	Drosophila melanogaster	232-237
34562831-1	2021	Phototropin (phot) is a blue light photoreceptor in plants and possesses two photosensory light-oxygen-voltage (LOV1 and LOV2) domains with different photo-thermochemical properties.	Oxygen	96-102	NAC domain containing protein 35	Arabidopsis thaliana	112-116
34481123-9	2021	CONCLUSION: These results provide evidence that LTBP3, via TGFbeta2, plays an important role in promoting brown adipogenesis by modulating UCP1 expression and mitochondrial oxygen consumption.	Oxygen	173-179	transforming growth factor beta 2	Homo sapiens	59-67
34490476-9	2021	Moreover, PFKFB3 silencing notably reversed the HG-induced decrease in oxygen consumption rate, and the HG-induced increase in extracellular acidification rate was rescued by PFKFB3 siRNA.	Oxygen	71-77	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	10-16
34268805-6	2021	Indeed, potassium cyanide abruptly stops oxygen uptake, indicating that the cytochrome c pathway is likely to be engaged.	Oxygen	41-47	cytochrome c	Solanum lycopersicum	76-88
34481229-5	2021	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.	Oxygen	480-486	TSC complex subunit 2	Homo sapiens	295-299
34729700-4	2021	CD146 expression was activated in two ocular pathological angiogenesis models, a laser-induced choroid neovascularization model and an oxygen-induced retinopathy model.	Oxygen	135-141	melanoma cell adhesion molecule	Homo sapiens	0-5
34764873-7	2021	In vitro, the cultured H9c2 cells or cardiac fibroblasts were exposed to 3% O2 for 48 h to induce hypertrophy or fibrosis, which showed hypertrophic (increases in cellular size as well as the expression of ANP and BNP) or fibrotic features (increases in the expression of collagen I, collagen III, and alpha-SMA).	Oxygen	76-78	natriuretic peptide A	Rattus norvegicus	206-209
34768827-2	2021	Irradiated BDNF-eMSCs hyper-secreted BDNF > 10 fold and were >5 fold more effective than naive MSCs in attenuating the oxygen-glucose deprivation-induced increase in cytotoxicity, oxidative stress, and cell death in vitro.	Oxygen	119-125	brain-derived neurotrophic factor	Rattus norvegicus	11-15
34617088-0	2021	A Cr-FeOOH@Ni-P/NF binder-free electrode as an excellent oxygen evolution reaction electrocatalyst.	Oxygen	57-63	neurofascin	Homo sapiens	16-18
34691163-7	2021	Diabetic SHRs pretreated with pioglitazone and adiponectin separately exerted improvements in antioxidant enzyme activities, abrogated arterial stiffness, and offset the increased production of reactive oxygen species and dyslipidemic effects of STZ, whereas the blood pressure values were significantly reduced in the irbesartan-treated groups (all P < 0.05).	Oxygen	203-209	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	47-58
34641738-0	2021	l-Thyroxine induces left ventricular remodeling and fibrosis in rats by upregulating miR-21 in a reactive oxygen-dependent mechanism: a protective role of N-acetylcysteine.	Oxygen	106-112	microRNA 21	Rattus norvegicus	85-91
2170530-1	1990	Signal transduction initiated by interaction of immune complexes (IC) with Fc gamma RII and Fc gamma RIII receptors on human neutrophils was studied by investigating the capacity of well-defined complexes to stimulate O2- generation in neutrophils.	Oxygen	218-220	Fc gamma receptor IIIa	Homo sapiens	92-105
2170530-9	1990	Cross-linking of either Fc gamma RII or Fc gamma RIII receptors on neutrophil surfaces induced O2- generation, and this activation was inhibited by both PGE1 and PTx treatment.	Oxygen	95-97	Fc gamma receptor IIIa	Homo sapiens	40-53
2170530-12	1990	Although insoluble IC induce O2- production through a PTx and PGE1 insensitive pathway mediated primarily through Fc gamma RIII receptor.	Oxygen	29-31	Fc gamma receptor IIIa	Homo sapiens	114-127
1698778-6	1990	3) The NH2- and COOH-terminal epitopes of cytochrome b6 were also more sensitive to trypsin added to thylakoid membranes than were the oxygen-evolving complex 16- and 33-kDa proteins that are completely located on the lumen side.	Oxygen	135-141	mitochondrially encoded cytochrome b	Homo sapiens	42-54
2241604-2	1990	It was found that the oxygen flux in the gas/membrane/liquid system was saturated when the oxygen flux (Fg-g) in the gas/membrane/gas system became more than 1.0 x 10(-5) cm3 (STP) cm-2s-1cm Hg-1 (Fcg-g).	Oxygen	22-28	thyroid hormone receptor interactor 10	Homo sapiens	176-179
2241604-2	1990	It was found that the oxygen flux in the gas/membrane/liquid system was saturated when the oxygen flux (Fg-g) in the gas/membrane/gas system became more than 1.0 x 10(-5) cm3 (STP) cm-2s-1cm Hg-1 (Fcg-g).	Oxygen	91-97	thyroid hormone receptor interactor 10	Homo sapiens	176-179
2241910-10	1990	Infusion of insulin had no effect on the glucose arterio-venous difference across the mammary gland, but did decrease the oxygen arterio-venous difference.	Oxygen	122-128	LOC105613195	Ovis aries	12-19
2122607-16	1990	It is concluded that although NADPH-cytochrome P-450 reductase is active in the one-electron reduction of mitomycin c, the actual metabolic locus for the reduction of this compound in liver microsomes under a relatively low O2 tension is more likely the haem site of cytochrome P-450.	Oxygen	224-226	cytochrome p450 oxidoreductase	Rattus norvegicus	30-62
6408094-5	1983	This behavior is very different from that observed for carbonic anhydrase II for which kCO2 cat and the rate of release of substrate oxygen are very pH-dependent.	Oxygen	133-139	carbonic anhydrase 2	Homo sapiens	55-76
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	Oxygen	155-157	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	40-44
34399025-2	2021	Crystal structure analysis revealed that each of these molecules adopts a conformation in which the azide and oxygen groups orient syn to each other with a short O     N b  contact.	Oxygen	110-116	synemin	Homo sapiens	131-134
34543021-3	2021	The three-dimensional (3D) porous hierarchical structure of Ni2P/Fe3O4/NF provides abundant active sites for OER and facilitates the electrolyte diffusion of ions and O2 liberation.	Oxygen	167-169	neurofascin	Homo sapiens	71-73
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Oxygen	181-183	thyroid peroxidase	Homo sapiens	0-18
34469202-5	2021	We found that ISM1 gene expression was upregulated in cultured AECII cells exposed to hypoxia (3% O2), and that AECII-derived ISM1 participated in hypoxia-induced hyperpermeability of PMVEC monolayers since siRNA-mediated knockdown of ISM1 in AECII markedly attenuated the increasement of PMVEC permeability in co-culture system under hypoxia.	Oxygen	98-100	isthmin 1	Homo sapiens	14-18
2118559-1	1990	The enzyme xanthine oxidase participates in the pathogenesis of tissue ischemia-reperfusion injury by depleting purine pools and generating toxic oxygen metabolites.	Oxygen	146-152	xanthine dehydrogenase	Mus musculus	11-27
2373157-1	1990	These studies show that GAPDH from the calf lens and human lens epithelium undergoes size and charge modifications in the presence of active oxygen species generated from methylene blue and light.	Oxygen	141-147	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	24-29
2213688-6	1990	Post-irradiation O2-saturated hydration caused maximal 8-day-old seedling injury, and increased peroxidase activity with concomitant reduction in total peroxides.	Oxygen	17-19	prx7	Hordeum vulgare	96-106
34157521-5	2021	Functional interactions between these receptors result in the activation of Rac1 via these adaptor proteins, thereby leading to Reactive Oxygen Species.	Oxygen	137-143	Rac family small GTPase 1	Homo sapiens	76-80
34482039-12	2021	CONCLUSIONS: Reversible alteration of mRNA levels by removing morphine from culture medium, and effect of NAC in co-treatment of morphine plus NAC, emphasize the role of reactive oxygen species in down-regulation of the expression of hTERT and TERF2 by morphine.	Oxygen	179-185	telomeric repeat binding factor 2	Homo sapiens	244-249
2193726-13	1990	Avoidance of complete intraoperative atelectasis of the ND-lung with a low level of air/oxygen CPAP.	Oxygen	88-94	centromere protein J	Homo sapiens	95-99
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Oxygen	181-183	thyroid peroxidase	Homo sapiens	20-23
6834391-5	1983	The omicron-quinone 7b has a rather low inhibitory effect against L1210 leukemia cell multiplication but acts as an electron carrier and dramatically augments the oxygen consumption in xanthine oxidase-NADH and rat liver microsomes-NADPH systems.	Oxygen	163-169	xanthine dehydrogenase	Mus musculus	185-201
2157445-5	1990	These and other observations indicated that these alkaloids inhibited the active oxygen generation by way of stabilizing plasma membrane and inhibiting PKC and NADPH oxidase activation.	Oxygen	81-87	Prkca	Cavia porcellus	152-155
34703896-2	2021	Methemoglobin is incapable of binding oxygen, leading to complications such as cyanosis, dyspnea, headache, and heart failure.	Oxygen	38-44	hemoglobin subunit gamma 2	Homo sapiens	0-13
34596290-1	2022	BACKGROUND: Under normal physiological conditions, the spin-lattice relaxation rate (R1) in blood is influenced by many factors, including hematocrit, field strength, and the paramagnetic effects of deoxyhemoglobin and dissolved oxygen.	Oxygen	229-235	spindlin 1	Homo sapiens	55-59
6301495-0	1983	The production of activated oxygen species by an interaction of methemoglobin with ascorbate.	Oxygen	28-34	hemoglobin subunit gamma 2	Homo sapiens	64-77
34548381-4	2021	The baseline oxygen consumption rate of CD8+ T cells was elevated in all infected individuals and CD8+ T cells were working at maximal respiratory capacity.	Oxygen	13-19	CD8a molecule	Homo sapiens	40-43
34548381-4	2021	The baseline oxygen consumption rate of CD8+ T cells was elevated in all infected individuals and CD8+ T cells were working at maximal respiratory capacity.	Oxygen	13-19	CD8a molecule	Homo sapiens	98-101
2155924-2	1990	The activities of adenosine deaminase (ADA) and xanthine oxidase (XO), which generates O2-, were elevated in the s-BALF, lung tissue homogenate, and serum (plasma).	Oxygen	87-90	xanthine dehydrogenase	Mus musculus	48-64
2154525-8	1990	LPS from Salmonella minnesota Re595 and its LPS-LBP and LPS-HDL complexes differed in their ability to prime PMN O2- production in response to formyl peptide (f-Nle-Leu-Phe-Nle-Tyr-Leu [FNLPNTL]).	Oxygen	113-115	lipopolysaccharide binding protein	Homo sapiens	48-51
6299382-2	1983	Spin traps were found to decrease the rate of oxygen uptake and the rate of haemoglobin oxidation in the reaction of phenylhydrazine with oxyhaemoglobin.	Oxygen	46-52	spindlin 1	Homo sapiens	0-4
2138279-1	1990	In the adult, atrial natriuretic peptide (ANP) regulates renal and cardiovascular function when blood volume is expanded, when atrial pressure is increased, and when arterial oxygen content is decreased.	Oxygen	175-181	natriuretic peptides A	Ovis aries	14-40
34478282-6	2021	In this work, we accessed a mixture of dinuclear iridium species from a coordination precursor, Na(Ir(pyalk)Cl4), and assayed their catalytic activity for oxygen evolution by using NaIO4 as the oxidant.	Oxygen	155-161	endogenous retrovirus group W member 3	Homo sapiens	108-111
6296101-13	1983	The results demonstrated that NADPH-cytochrome P-450 reductase may represent an important locus of oxygen activation leading to the production of a highly oxidizing species characteristic of the hydroxyl radical.	Oxygen	99-105	cytochrome p450 oxidoreductase	Rattus norvegicus	30-62
34465083-6	2021	The results provide the following insights into the effects of the bridging unit (sulfur vs oxygen) and the dibenzo-annulation on the spin delocalization in the bridged triarylamine radical cations: (1) An effective decrease of the spin density on the nitrogen atom is observed for the sulfur bridge relative to the oxygen bridge; and (2) a moderate decrease of the spin density on the oxygen atom rather than the nitrogen atom is induced by the dibenzo-annulation.	Oxygen	386-392	spindlin 1	Homo sapiens	134-138
34465083-6	2021	The results provide the following insights into the effects of the bridging unit (sulfur vs oxygen) and the dibenzo-annulation on the spin delocalization in the bridged triarylamine radical cations: (1) An effective decrease of the spin density on the nitrogen atom is observed for the sulfur bridge relative to the oxygen bridge; and (2) a moderate decrease of the spin density on the oxygen atom rather than the nitrogen atom is induced by the dibenzo-annulation.	Oxygen	386-392	spindlin 1	Homo sapiens	366-370
34577080-3	2021	Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H2O2 to form O2, thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen (1O2) production with infrared irradiation.	Oxygen	124-126	hydroxyacid oxidase 1	Homo sapiens	34-37
2405838-14	1990	The dual activation of these serial processes coupled to the loss of the reaction products of the pentose phosphate-shunt pathway from the cells in the form of reactive oxygen intermediates, protons and CO2 could explain the synergistic action of phorbol and mCSF-1 in activation of sugar transport in macrophages.	Oxygen	169-175	colony stimulating factor 1 (macrophage)	Mus musculus	259-265
2386522-4	1990	Increase in app Hb-oxygen affinity after exercise was found by measurements of p25 and by differences between plots of correlations between V O2 max and resting and post-exercise parameters of Hb-oxygen binding.	Oxygen	19-25	tubulin polymerization promoting protein	Homo sapiens	79-82
2076828-1	1990	Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls.	Oxygen	170-176	solute carrier family 6 member 3	Homo sapiens	304-307
6404265-1	1983	NADPH-dependent O2- generating oxidoreductase activity recovered from cell lysates of phorbol myristate acetate-stimulated human neutrophils exhibits dependence on Ca+2 and Mg+2 for full expression of its catalytic activity.	Oxygen	16-18	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
34495409-8	2021	PC12 cells deprived of oxygen/glucose developed signs of cellular injury (LDH release and necroptosis) concomitant with downregulation of Pellino3, decreased ubiquitination of RIPK1, and elevated necroptosis-associated proteins.	Oxygen	23-29	receptor interacting serine/threonine kinase 1	Rattus norvegicus	176-181
34571983-5	2021	CAR T-cells expressing LbNOX have enhanced oxygen as well as lactate consumption and increased pyruvate production.	Oxygen	43-49	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-3
34571964-5	2021	Amongst enzymatic sources of O2 - the Nox2 isoform of NADPH oxidase is thought to be critical to the oxidative stress found in type 2 diabetes mellitus.	Oxygen	29-31	cytochrome b-245 beta chain	Homo sapiens	38-42
2259557-10	1990	However, in spite of intubation immediately after birth and the application of continuous positive pressure ventilation during the first 3 days of life, very low birthweight infants with RDS continue to have significant alteration in lung function, evidenced by impaired diffusing capacity of the lung and low arterial-alveolar oxygen tension ratios.	Oxygen	328-334	peripherin 2	Homo sapiens	187-190
33768623-2	2021	The NiFc-MOF/NF exhibits superior oxygen evolution reaction (OER) performance with an overpotential of 195 mV and 241 mV at 10 and 100 mA cm -2 , respectively and long-term stability up to 40 h under alkaline conditions.	Oxygen	34-40	neurofascin	Homo sapiens	13-15
33769637-2	2021	Formation of the oxidized nucleotides hmdC, fdC and cadC requires oxidation of mdC by ten-eleven translocation (Tet) enzymes that require oxygen, Fe(II) and a-ketoglutarate as cosubstrates.	Oxygen	138-144	heterogeneity of muscle Gapd decay constants	Mus musculus	38-42
33787215-6	2021	An optimized spin density of CoHS results in an optimal binding energy of oxygen species for the OER.	Oxygen	74-80	spindlin 1	Homo sapiens	13-17
34270373-6	2021	Furthermore, Ang II-induced increased levels of superoxide anion (O2-) and NADPH oxidase activity and increased phosphorylation of ERK1/2 and AKT that are implicated in enhanced expression of Gialpha proteins and hyperproliferation of VSMC were also attenuated to control levels by silencing of Sirt1.	Oxygen	66-69	sirtuin 1	Homo sapiens	295-300
6404265-1	1983	NADPH-dependent O2- generating oxidoreductase activity recovered from cell lysates of phorbol myristate acetate-stimulated human neutrophils exhibits dependence on Ca+2 and Mg+2 for full expression of its catalytic activity.	Oxygen	16-18	thioredoxin reductase 1	Homo sapiens	31-45
6404265-2	1983	O2- generating activity was completely abolished by exposure of the oxidoreductase to EDTA, then reconstituted by exposure of the enzyme to Ca+2 and Mg+2 in excess of the EDTA concentration used to block catalytic activity.	Oxygen	0-2	thioredoxin reductase 1	Homo sapiens	68-82
34479975-2	2021	Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation.See related article by Papachristodoulou et al., p. 2316.	Oxygen	116-122	NK3 homeobox 1	Homo sapiens	34-40
33805516-9	2021	These results showed that XOR-mediated O2 - production is relatively uninvolved in the age-related pathologies in Sod1-/- mice.	Oxygen	39-43	xanthine dehydrogenase	Mus musculus	26-29
6404265-5	1983	The molar ratio of NADPH oxidation to O2- production determined at pH 7.6 in the presence of Ca+2 and Mg+2 is 0.49, indicating 1 mole of NADPH oxidized per 2 moles of O2- formed.	Oxygen	38-40	2,4-dienoyl-CoA reductase 1	Homo sapiens	19-24
6404265-5	1983	The molar ratio of NADPH oxidation to O2- production determined at pH 7.6 in the presence of Ca+2 and Mg+2 is 0.49, indicating 1 mole of NADPH oxidized per 2 moles of O2- formed.	Oxygen	38-40	2,4-dienoyl-CoA reductase 1	Homo sapiens	137-142
32796056-0	2021	In vitro evaluation of delays in the adjustment of the fraction of inspired oxygen during CPAP: effect of flow and volume.	Oxygen	76-82	centromere protein J	Homo sapiens	90-94
6404265-5	1983	The molar ratio of NADPH oxidation to O2- production determined at pH 7.6 in the presence of Ca+2 and Mg+2 is 0.49, indicating 1 mole of NADPH oxidized per 2 moles of O2- formed.	Oxygen	167-169	2,4-dienoyl-CoA reductase 1	Homo sapiens	19-24
34115276-4	2021	The surface of ACNp is highly negatively charged due to the presence of oxygen rich functional groups and it is confirmed by zeta potential.	Oxygen	72-78	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	15-19
6404265-5	1983	The molar ratio of NADPH oxidation to O2- production determined at pH 7.6 in the presence of Ca+2 and Mg+2 is 0.49, indicating 1 mole of NADPH oxidized per 2 moles of O2- formed.	Oxygen	167-169	2,4-dienoyl-CoA reductase 1	Homo sapiens	137-142
6133026-5	1983	Insulin administered after the obsidan beta-adrenergic block was found to limit coronary dilatation and reduce myocardial oxygen consumption in a more pronounced measure.	Oxygen	122-128	insulin	Canis lupus familiaris	0-7
34396769-4	2021	The noncovalent binding between the light-oxygen-voltage-sensing domain 2 (LOV2) and its binding partner ZDark1 (zdk1), named as LOVTRAP, is a light-responsive interaction.	Oxygen	42-48	TRAP	Homo sapiens	129-136
33776217-9	2021	Here, the case is described where the second relaxation process, namely Heisenberg exchange between the spin label and molecular oxygen that occurs during bimolecular collisions, contributes to the decay of SR signals.	Oxygen	129-135	spindlin 1	Homo sapiens	104-108
6133026-6	1983	It is suggested that the effect of insulin on coronary dilatation is due to reduced myocardial oxygen consumption resulting from its action on the heart"s beta-adrenergic systems.	Oxygen	95-101	insulin	Canis lupus familiaris	35-42
25784301-7	2015	XPS and FTIR spectra confirmed that oxygen and nitrogen atoms notably contributed to BDE-209 binding.	Oxygen	36-42	homeobox D13	Homo sapiens	85-88
34342219-3	2021	Herein, we constructed a self-sufficient hybrid enzyme-based silk fibroin hydrogel system, consisting of Pt-decorated hollow Ag-Au trimetallic nanocages (HGN@Pt) and glucose oxidase (GOx), to supply O2 continuously and consume glucose concurrently and, thereby, synergistically enhance the anti-cancer efficacy of a combined starvation and photothermal therapy operating in a hypoxic tumor microenvironment.	Oxygen	199-201	hydroxyacid oxidase 1	Homo sapiens	166-181
34342219-3	2021	Herein, we constructed a self-sufficient hybrid enzyme-based silk fibroin hydrogel system, consisting of Pt-decorated hollow Ag-Au trimetallic nanocages (HGN@Pt) and glucose oxidase (GOx), to supply O2 continuously and consume glucose concurrently and, thereby, synergistically enhance the anti-cancer efficacy of a combined starvation and photothermal therapy operating in a hypoxic tumor microenvironment.	Oxygen	199-201	hydroxyacid oxidase 1	Homo sapiens	183-186
7159446-0	1982	Diffusion of oxygen in methemoglobin solutions.	Oxygen	13-19	hemoglobin subunit gamma 2	Homo sapiens	23-36
34342219-9	2021	Finally, the O2 supplied by HGN@Pt overcame the hypoxia of the microenvironment and, thereby, promoted the starvation therapeutic effect of the GOx-mediated glucose consumption.	Oxygen	13-15	hydroxyacid oxidase 1	Homo sapiens	144-147
34342219-10	2021	Meanwhile, the GOx-produced H2O2 from the oxidation of glucose could be used to regenerate O2 and, thereby, construct a complementary circulatory system.	Oxygen	91-93	hydroxyacid oxidase 1	Homo sapiens	15-18
34376676-0	2021	Spin-sate reconfiguration induced by alternating magnetic field for efficient oxygen evolution reaction.	Oxygen	78-84	spindlin 1	Homo sapiens	0-4
24751879-1	2014	Wnt/beta-catenin signaling induced by the Norrin/Frizzled-4 pathway has been shown to improve capillary repair following oxygen induced retinopathy (OIR) in the mouse, a model for retinopathy of prematurity.	Oxygen	121-127	catenin (cadherin associated protein), beta 1	Mus musculus	4-16
6817788-0	1982	Solvent deuterium isotope effects in the catalysis of oxygen-18 exchange by human carbonic anhydrase II.	Oxygen	54-60	carbonic anhydrase 2	Homo sapiens	82-103
34915296-6	2022	The catalytic mechanism of the NADH oxidase mimics is that O2 involves in the oxidation of NADH, to generate O2.- intermediate and finally turn to H2O2, while SuOx mimics comes from that MoS2 particles can effectively catalyze sulfite to reduce (Fe(CN)6)3-.	Oxygen	109-111	sulfite oxidase	Homo sapiens	159-163
34890952-6	2022	Both superoxide radicals (O2 -) and non-radical of singlet oxygen (1O2) were the primary reactive oxygen species (ROS) in the Fe/Fe3C@NCNF-800/PMS system via quenching tests and electron spin resonance spectroscopy (ESR).	Oxygen	26-30	general transcription factor IIE subunit 1	Homo sapiens	126-128
34896831-5	2022	Once the bioreactor reached the desired region, GOx promptly consumed the intratumoral glucose and oxygen to starve cancer cells for robust starvation therapy.	Oxygen	99-105	hydroxyacid oxidase 1	Homo sapiens	48-51
34349016-5	2021	Furthermore, both MCAO in vivo and oxygen-glucose deprivation in vitro revealed that Npas4 is necessary and sufficient for neuroprotection.	Oxygen	35-41	neuronal PAS domain protein 4	Homo sapiens	85-90
34174286-2	2021	CRL2VHL plays important roles in oxygen sensing by targeting Hypoxia Inducible Factor-alpha (HIF-alpha) subunits for ubiquitination and degradation.	Oxygen	33-39	DAN domain BMP antagonist family member 5	Homo sapiens	0-7
34355032-10	2021	After adjustment, CA 125 still positively correlated with World Health Organization functional class, NT-proBNP, right ventricular end-diastolic diameter, pericardial effusion, mean right atrial pressure and pulmonary arterial wedge pressure; negatively correlated with 6-min walk distance, left ventricular end-diastolic diameter, mixed venous oxygen saturation, and cardiac index.	Oxygen	345-351	mucin 16, cell surface associated	Homo sapiens	18-24
34990970-0	2022	An alkane monooxygenase (AlkB) family in which all electron transfer partners are covalently bound to the oxygen-activating hydroxylase.	Oxygen	106-112	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	25-29
6817788-1	1982	By measuring the rate of exchange at chemical equilibrium of 18O between HCO3- and H2O catalyzed by human carbonic anhydrase II in the absence of buffers, we have determined the rate of release from the enzyme of water bearing substrate oxygen.	Oxygen	237-243	carbonic anhydrase 2	Homo sapiens	106-127
34990970-3	2022	Activation of AlkB occurs via two-electron reduction of its diferric active site, which facilitates the binding, activation, and cleavage of molecular oxygen for insertion into an inert CH bond.	Oxygen	151-157	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	14-18
34285351-2	2021	A study of Vegfa isoform expression during oxygen-induced ischemic retinopathy (OIR) may enhance our understanding of Vegf dysregulation.	Oxygen	43-49	vascular endothelial growth factor A	Mus musculus	11-16
6282499-7	1982	The results suggest that a component of "ischemic" cardiac damage may involve cytotoxicity from oxygen metabolites such as superoxide anion, hydrogen peroxide, or both, and that this component of damage can be reduced by enzyme supplements such as superoxide dismutase or catalase.	Oxygen	96-102	catalase	Felis catus	272-280
34285351-2	2021	A study of Vegfa isoform expression during oxygen-induced ischemic retinopathy (OIR) may enhance our understanding of Vegf dysregulation.	Oxygen	43-49	vascular endothelial growth factor A	Mus musculus	118-122
34259420-11	2021	Furthermore, inhibition of the organic anion transporter 2 with ketoprofen reverted eryptosis and restored the levels of intracellular oxygen.	Oxygen	135-141	solute carrier family 22 member 7	Homo sapiens	31-58
34877682-10	2022	Despite the high level of homology between Orai proteins, CRAC channels formed by different Orai isoforms have distinctive properties, particularly with regards to Ca2+ dependent inactivation, inhibition/potentiation by 2-Aminoethyl diphenylborinate (2-APB) and sensitivity to reactive oxygen species.	Oxygen	286-292	ORAI calcium release-activated calcium modulator 1	Homo sapiens	92-96
34896860-4	2022	Herein, a biocompatible carbon nitride (C3N4)/nanozyme/GOx triple cascade nanocatalyst was designed with laser-activatable O2 self-supply via water splitting to relieve tumor hypoxia and thus improve the catalysis efficiency.	Oxygen	123-125	hydroxyacid oxidase 1	Homo sapiens	55-58
6127643-3	1982	When the tissue PO2 was elevated to a level high enough to saturate hemoglobin, the ODR reflected the oxygen consumption rate which was calculated to range from 1.6-7.4 cc O2/100 cc tissue-min.	Oxygen	102-108	immunoglobulin kappa variable 1D-39	Homo sapiens	172-178
34369657-0	2022	JMJD5 attenuates oxygen-glucose deprivation and reperfusion-induced injury in cardiomyocytes through regulation of HIF-1alpha-BNIP3.	Oxygen	17-23	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	115-125
34341659-5	2021	Large infiltrates by Arginase 1+ G-MDSC (Arg+G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen species) were found in the lungs of patients who died from COVID-19 complications.	Oxygen	119-125	cytochrome b-245 beta chain	Homo sapiens	75-80
7178061-3	1982	CS2--50 and 200 mg/m3 were established to inhibit oxygen consumption of liver homogenates, better manifested in female animals, whereas in homogenates of testicles the tissue respiration was significantly inhibited only with 200 mg/m3.	Oxygen	50-56	calsyntenin 2	Rattus norvegicus	0-3
34238362-4	2021	CASE PRESENTATION: A-15 year-old Saudi male presented to the emergency department with a history of shortness of breath and low oxygen saturation.	Oxygen	128-134	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	19-23
34242227-8	2021	We present evidence that the crosstalk between HIF-1 and SKN-1 is mediated by EGL-9, the prolyl hydroxylase that targets HIF-1 for oxygen-dependent degradation.	Oxygen	131-137	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	78-83
34239013-3	2021	ATF4 induction in GB cells was modulated pharmacologically and genetically and investigated in the context of temozolomide treatment as well as glucose and oxygen deprivation.	Oxygen	156-162	activating transcription factor 4	Homo sapiens	0-4
34570375-11	2022	The role of reactive oxygen species in endothelial dysfunction was confirmed by DHE fluorescence, nitrotyrosine overexpression, and upregulation of NOX2 in the different ADT treatment groups.	Oxygen	21-27	cytochrome b-245 beta chain	Rattus norvegicus	148-152
34987705-8	2021	Indeed, GATA4 is upregulated in CRC-AA cells and augments the NF-kappaB activity that underlies the increased expression of cytokines, inhibition of apoptosis, and reduction of reactive oxygen species.	Oxygen	186-192	GATA binding protein 4	Homo sapiens	8-13
34239013-9	2021	Our experimental study provides evidence for an important role of ATF4 for the adaptation of human GB cells to conditions of the tumor microenvironment characterized by low oxygen and nutrient availability and for the development of temozolomide resistance.	Oxygen	173-179	activating transcription factor 4	Homo sapiens	66-70
7053127-1	1981	Enhancement of spin-lattice relaxation using oral ferric chloride and using inhaled oxygen is illustrated.	Oxygen	84-90	spindlin 1	Homo sapiens	15-19
34108686-5	2021	Conditional deletion of TIM-3 in DCs led to increased accumulation of reactive oxygen species resulting in NLRP3 inflammasome activation.	Oxygen	79-85	hepatitis A virus cellular receptor 2	Homo sapiens	24-29
34854694-1	2021	Represented is a CuX2- or I2-promoted ring-opening dual halogenation of cyclopropenones with saturated oxygen heterocycles, providing an efficient method for the synthesis of 3-haloacrylates.	Oxygen	103-109	cut like homeobox 2	Homo sapiens	17-21
7053127-3	1981	In 5 volunteers inhalation of 100% oxygen decreased the mean observed spin-lattice relaxation time of blood within the left ventricular cavity.	Oxygen	35-41	spindlin 1	Homo sapiens	70-74
34919733-5	2022	Oxygen consumption rate measurements in aox1a and aox1d leaves suggested these AOXs can functionally compensate for each other to establish enhanced AOX catalytic capacity in response to Pro.	Oxygen	0-6	alternative oxidase 1D	Arabidopsis thaliana	50-55
34906113-12	2021	Overexpression of TRAP1 in CAFs increased basal oxygen consumption rate (OCR), maximal respiration, ATP production and SRC.	Oxygen	48-54	TNF receptor associated protein 1	Homo sapiens	18-23
34109953-4	2021	Co-N-Ni3S2/NF exhibits excellent oxygen evolution reaction activity (an overpotential of 285 mV@50 mA cm-2) and hydrogen evolution reaction activity (an overpotential of 215 mV@10 mA cm-2) in 1 M KOH solution.	Oxygen	33-39	neurofascin	Homo sapiens	5-13
34202015-1	2021	In this study, ratiometric fluorescent glucose and lactate biosensors were developed using a ratiometric fluorescent oxygen-sensing membrane immobilized with glucose oxidase (GOD) or lactate oxidase (LOX).	Oxygen	117-123	lysyl oxidase	Homo sapiens	200-203
34202015-3	2021	The operation mechanism of the sensing membranes was based on (i) the fluorescence quenching effect of the PtP dye by oxygen molecules, and (ii) the consumption of oxygen levels in the glucose or lactate oxidation reactions under the catalysis of GOD or LOX.	Oxygen	118-124	lysyl oxidase	Homo sapiens	254-257
34202015-3	2021	The operation mechanism of the sensing membranes was based on (i) the fluorescence quenching effect of the PtP dye by oxygen molecules, and (ii) the consumption of oxygen levels in the glucose or lactate oxidation reactions under the catalysis of GOD or LOX.	Oxygen	164-170	lysyl oxidase	Homo sapiens	254-257
34384891-2	2021	Myoglobin (MB), known to store or transport oxygen in heart and skeletal muscles, has recently been found to bind fatty acids with physiological constants in its oxygenated form (i.e., MBO2).	Oxygen	44-50	myoglobin	Mus musculus	0-9
6275773-1	1981	The mannose monosaccharide residue in ristomycin A is bound via C-3 phenolic oxygen of the 1,2,3,5-substituted ring with actinoidinic amino acid.	Oxygen	77-83	complement C3	Homo sapiens	64-67
34384891-2	2021	Myoglobin (MB), known to store or transport oxygen in heart and skeletal muscles, has recently been found to bind fatty acids with physiological constants in its oxygenated form (i.e., MBO2).	Oxygen	44-50	myoglobin	Mus musculus	11-13
34900840-10	2021	It can be said that diabetes with the action of reactive oxygen species through oxidative stress, increases ICAM-1 and TNF-alpha and decreases heparanase enzyme, it affects the glomerular endothelium and eventually leads to albuminuria and destruction of the Glx layer.	Oxygen	57-63	intercellular adhesion molecule 1	Homo sapiens	108-114
34198034-3	2021	The results indicated that packaging radish roots under 10% O2 prevents blue discoloration by decreasing the activity and expression of the oxidant enzyme POD, increasing the levels of antioxidant and reducing substances, and upregulating antioxidant enzymes, all of which act to decrease the generation of ROS (O2- and H2O2).	Oxygen	60-62	peroxidase E5-like	Raphanus sativus	155-158
6794956-3	1981	Normal or increased activities were found for certain erythrocyte enzymes involved in the detoxification of activated oxygen: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase.	Oxygen	118-124	glucose-6-phosphate dehydrogenase	Homo sapiens	126-159
34224586-9	2021	In Doxorubicin-treated H9C2 cardiomyocytes, cell senescence marker p21 and reactive oxygen species were significantly reduced after cultured with MR409.	Oxygen	84-90	KRAS proto-oncogene, GTPase	Rattus norvegicus	67-70
34145303-9	2021	Both MT-CO2 and the neutrophil chemoattractant CXCL1 are induced by reactive oxygen in bronchial epithelial cells.	Oxygen	77-83	C-X-C motif chemokine ligand 1	Homo sapiens	47-52
6272308-3	1981	Experiments with 18O2 and H218O indicated that in all six compounds the hydroxyl group at C-15 was derived from molecular oxygen.	Oxygen	122-128	placenta associated 8	Homo sapiens	90-94
34133418-10	2021	Oxygen supply by newly formed blood vessels improves local hypoxia and decreases VEGF expression at the angiogenic front during angiogenesis.	Oxygen	0-6	vascular endothelial growth factor A	Mus musculus	81-85
34447562-3	2021	TMSNTf2 was proposed to work through an unprecedented metal-free "coordination-insertion" mechanism, which involves the coordination of monomer to the Si atom of TMSNTf2, the nucleophilic attack of the -NTf2 group on the coordinated monomer, and the cleavage of the acyl-oxygen bond of the monomer.	Oxygen	271-277	nuclear transport factor 2	Homo sapiens	0-7
34757365-4	2021	In the case of off-targeting, when very few CeO2-GOx@CCM nanoparticles were accidentally delivered into normal tissue, its neutral pH environment (pH = 7.4) triggered a protective reaction, in which the H2O2 generated was catalyzed by CeO2 into non-toxic H2O and O2.	Oxygen	263-265	hydroxyacid oxidase 1	Homo sapiens	49-52
34447562-3	2021	TMSNTf2 was proposed to work through an unprecedented metal-free "coordination-insertion" mechanism, which involves the coordination of monomer to the Si atom of TMSNTf2, the nucleophilic attack of the -NTf2 group on the coordinated monomer, and the cleavage of the acyl-oxygen bond of the monomer.	Oxygen	271-277	nuclear transport factor 2	Homo sapiens	162-169
34661812-0	2021	Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner.	Oxygen	56-62	small nucleolar RNA host gene 7	Mus musculus	20-25
7284355-3	1981	52, 107--116) the reduction of cytochrome b in beef-heart submitochondrial particles by succinate in the presence of antimycin was found to be biphasic, the relative amounts of fast and slow phases being dependent on the redox state of a compound located on the oxygen side of the antimycin block.	Oxygen	262-268	mitochondrially encoded cytochrome b	Homo sapiens	31-43
34661812-2	2021	The study aimed to disclose SNHG7 role in oxygen and glucose deprivation (OGD)-induced Neuro-2a (N2a) cell disorders.	Oxygen	42-48	small nucleolar RNA host gene 7	Mus musculus	28-33
34517657-2	2021	Herein, an interrelated catalytic enzyme system has been developed, termed as CataFlower, which is composed of nanoflower MoS2 (peroxidase) decorated with GOx (glucose oxidase) and MnO2 (oxygen generator), and exhibits synergistic oxidative capability for sensitively monitoring sweat glucose.	Oxygen	187-193	hydroxyacid oxidase 1	Homo sapiens	155-158
34868528-15	2021	In conclusion, SNHG15 expression increased during the process of oxygen-glucose-deprived reoxygenation, and the oxidative stress process was reduced by miR-141/SIRT1.	Oxygen	65-71	small nucleolar RNA host gene 15	Homo sapiens	15-21
34868528-15	2021	In conclusion, SNHG15 expression increased during the process of oxygen-glucose-deprived reoxygenation, and the oxidative stress process was reduced by miR-141/SIRT1.	Oxygen	65-71	sirtuin 1	Homo sapiens	160-165
34457393-6	2021	Reoxygenation in anti-CTLA-4-treated tumors was due to a combination of increased oxygenated hemoglobin and decreased deoxygenated hemoglobin, pointing to a possible change in tumor oxygen consumption following treatment.	Oxygen	182-188	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	22-28
7272340-0	1981	Calmodulin antagonists modulate rabbit neutrophil degranulation, aggregation and stimulated oxygen consumption.	Oxygen	92-98	calmodulin	Oryctolagus cuniculus	0-10
34103063-6	2021	Finally, the expression of CD146 in OS was detected under different culture conditions, including hyperoxia, low oxygen, high glucose and low glucose conditions.	Oxygen	113-119	melanoma cell adhesion molecule	Homo sapiens	27-32
34098948-15	2021	CONCLUSION: These findings help elucidate the underlying immune and oxygen regulation mechanisms associated with the VEGF signaling pathway in heat-stressed dairy cattle.	Oxygen	68-74	vascular endothelial growth factor A	Bos taurus	117-121
34149701-6	2021	Additionally, activated CD8+ T cells that migrate on ICAM-1 and CXCL12 consumed significantly more oxygen than stationary CD8+ T cells.	Oxygen	99-105	CD8a molecule	Homo sapiens	24-27
34149701-6	2021	Additionally, activated CD8+ T cells that migrate on ICAM-1 and CXCL12 consumed significantly more oxygen than stationary CD8+ T cells.	Oxygen	99-105	intercellular adhesion molecule 1	Homo sapiens	53-59
34823575-11	2021	CONCLUSIONS: In this study, we demonstrated that activation of PINK1 is a requisite in osteoblasts during differentiation, which is related to mitochondrial quality control and low reactive oxygen species production.	Oxygen	190-196	PTEN induced kinase 1	Homo sapiens	63-68
34726226-4	2021	For synergistic cancer therapy, oxygen (O2) carried by PDA-PVAMBs@GOx was first released to promote starvation therapy by loaded GOx.	Oxygen	32-38	hydroxyacid oxidase 1	Homo sapiens	66-69
34726226-4	2021	For synergistic cancer therapy, oxygen (O2) carried by PDA-PVAMBs@GOx was first released to promote starvation therapy by loaded GOx.	Oxygen	32-38	hydroxyacid oxidase 1	Homo sapiens	129-132
34726226-4	2021	For synergistic cancer therapy, oxygen (O2) carried by PDA-PVAMBs@GOx was first released to promote starvation therapy by loaded GOx.	Oxygen	40-42	hydroxyacid oxidase 1	Homo sapiens	66-69
34726226-4	2021	For synergistic cancer therapy, oxygen (O2) carried by PDA-PVAMBs@GOx was first released to promote starvation therapy by loaded GOx.	Oxygen	40-42	hydroxyacid oxidase 1	Homo sapiens	129-132
34726226-5	2021	Then, moderate near-infrared (NIR) laser irradiation triggered PTT and improved enzymatic activity of GOx with its optimal activity around 47  C. Subsequently, GOx-mediated tumor starvation depleted O2 and exacerbated the hypoxia environment, thereby activating the toxicity of TPZ in the tumor site.	Oxygen	199-201	hydroxyacid oxidase 1	Homo sapiens	102-105
34726226-5	2021	Then, moderate near-infrared (NIR) laser irradiation triggered PTT and improved enzymatic activity of GOx with its optimal activity around 47  C. Subsequently, GOx-mediated tumor starvation depleted O2 and exacerbated the hypoxia environment, thereby activating the toxicity of TPZ in the tumor site.	Oxygen	199-201	hydroxyacid oxidase 1	Homo sapiens	160-163
7272340-4	1981	Aggregation, oxygen consumption and granule enzyme release stimulated by the above three stimuli are all profoundly affected by calmodulin inhibitors.	Oxygen	13-19	calmodulin	Oryctolagus cuniculus	128-138
34093012-4	2021	Perfluorohexanoate-modified cisplatin (FCP), as oxygen carriers, was encapsulated into mPEG-lys(Ce6)-PGA-AIM micelles.	Oxygen	48-54	FCP1	Homo sapiens	39-42
7462239-4	1981	The rates of O2- production and NADPH consumption are consistent with the stoichiometry: 2 O2 + NADPH leads to 2 O2- + NADP The enzyme is highly specific for oxygen, failing to reduce several artificial electron acceptors including ferricyanide.	Oxygen	13-15	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
34163669-5	2021	We demonstrated that SfmD heme is catalytically active and can utilize dioxygen and ascorbate for a single-oxygen insertion into 3-methyl-l-tyrosine.	Oxygen	71-79	N-sulfoglucosamine sulfohydrolase	Homo sapiens	21-25
34163669-5	2021	We demonstrated that SfmD heme is catalytically active and can utilize dioxygen and ascorbate for a single-oxygen insertion into 3-methyl-l-tyrosine.	Oxygen	107-113	N-sulfoglucosamine sulfohydrolase	Homo sapiens	21-25
34811946-11	2022	Notably, there is a marked decrease in reactive oxygen species in MyD88-deficient IECs during PQ exposure (~70% reduction), which are consistent with high activity of antioxidative enzymes (~83% increment) (P < 0.001).	Oxygen	48-54	myeloid differentiation primary response gene 88	Mus musculus	66-71
34901882-2	2021	sGC is a heterodimer, composed of an alpha1 and a beta1 subunit, of which the latter contains the heme-nitric oxide/oxygen (H-NOX) domain, responsible for NO recognition, binding and signal initiation.	Oxygen	116-122	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	37-55
7462239-4	1981	The rates of O2- production and NADPH consumption are consistent with the stoichiometry: 2 O2 + NADPH leads to 2 O2- + NADP The enzyme is highly specific for oxygen, failing to reduce several artificial electron acceptors including ferricyanide.	Oxygen	91-93	2,4-dienoyl-CoA reductase 1	Homo sapiens	32-37
7462239-4	1981	The rates of O2- production and NADPH consumption are consistent with the stoichiometry: 2 O2 + NADPH leads to 2 O2- + NADP The enzyme is highly specific for oxygen, failing to reduce several artificial electron acceptors including ferricyanide.	Oxygen	91-93	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
34820194-9	2021	The main pathways of IL20RA-related differentially expressed genes in TCGA were protein heterodimerization activity, oxygen binding, oxygen transporter activity, hormone activity, and lipid transporter activity.	Oxygen	117-123	interleukin 20 receptor subunit alpha	Homo sapiens	21-27
34178203-8	2021	Similar reactivity patterns were also observed in oxidations of TiO2/e - by O2, which like 4-MeO-TEMPO is a proton-coupled electron transfer (PCET) oxidant, and by the pure electron transfer (ET) oxidant KI3.	Oxygen	76-78	tyrosine kinase with immunoglobulin like and EGF like domains 1	Homo sapiens	64-70
7462239-4	1981	The rates of O2- production and NADPH consumption are consistent with the stoichiometry: 2 O2 + NADPH leads to 2 O2- + NADP The enzyme is highly specific for oxygen, failing to reduce several artificial electron acceptors including ferricyanide.	Oxygen	158-164	2,4-dienoyl-CoA reductase 1	Homo sapiens	32-37
34820194-9	2021	The main pathways of IL20RA-related differentially expressed genes in TCGA were protein heterodimerization activity, oxygen binding, oxygen transporter activity, hormone activity, and lipid transporter activity.	Oxygen	133-139	interleukin 20 receptor subunit alpha	Homo sapiens	21-27
34820194-13	2021	IL20RA"s involvement in the development and progression of CRC might occur through it affecting fatty acid metabolism, oxygen binding, oxygen transport, and hormone activity.	Oxygen	119-125	interleukin 20 receptor subunit alpha	Homo sapiens	0-6
7462239-4	1981	The rates of O2- production and NADPH consumption are consistent with the stoichiometry: 2 O2 + NADPH leads to 2 O2- + NADP The enzyme is highly specific for oxygen, failing to reduce several artificial electron acceptors including ferricyanide.	Oxygen	158-164	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
34820194-13	2021	IL20RA"s involvement in the development and progression of CRC might occur through it affecting fatty acid metabolism, oxygen binding, oxygen transport, and hormone activity.	Oxygen	135-141	interleukin 20 receptor subunit alpha	Homo sapiens	0-6
7213760-1	1981	Salicylate hydroxylase (salicylate, NADH: oxygen oxidoreductase (1-hydroxylating, decarboxylating), EC 1.14.13.1) in Pseudomonas putida catalyzed hydroxylation of the substrate analogue, salicylaldehyde, to form catechol and formate with stoichiometric consumption of NADH and O2.	Oxygen	277-279	salicylate hydroxylase	Pseudomonas putida	0-22
34591791-5	2021	This peptide enhanced the ATP synthase construction by interacting with the subunit alpha and gamma (ATP5A and ATP5C), increased ATP synthase activity and mitochondrial oxygen consumption rate, and thereby promoted colorectal cancer cell proliferation.	Oxygen	169-175	ATP synthase F1 subunit gamma	Homo sapiens	111-116
34384787-6	2021	In addition, through our gain- and loss-of-function studies we showed that FoxP4 regulates the expression of a number of classic brown and beige fat genes and affects oxygen consumption in isolated adipocytes.	Oxygen	167-173	forkhead box P4	Homo sapiens	75-80
7225119-0	1981	Simultaneous demonstration of phagocytosis-connected oxygen consumption and corresponding NAD(P)H oxidase activity: direct evidence for NADPH as the predominant electron donor to oxygen in phagocytizing human neutrophils.	Oxygen	179-185	2,4-dienoyl-CoA reductase 1	Homo sapiens	136-141
35500311-7	2022	Ultimately, the quenching labels of streptavidin modified Pt nanoparticles functionalized polydopamine composites (SA-Pt@PDA) were introduced via biotin and streptavidin recognition, realizing ECL emission quenching of S2O82-/O2 system for "on-off" detection of BCR-ABL fusion gene.	Oxygen	226-228	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	262-269
35339961-5	2022	A conceivable NO removal mechanism dominated by  O2- and 1O2 was proposed and verified based on the theoretical calculations and in-situ infrared spectroscopy tests, where hazardous NO was oxidized following two different exothermic pathways: the  O2--induced NO   NO3- process and the 1O2-induced NO   NO2   NO3- process.	Oxygen	248-250	immunoglobulin kappa variable 1D-39	Homo sapiens	49-60
35388555-2	2022	The reaction starts with the attack of a 4-dimethylaminopyridine (DMAP)-boryl radical to the carbonyl oxygen atom, followed by a spin-center shift (SCS) to trigger the C-O bond scission.	Oxygen	102-108	spindlin 1	Homo sapiens	129-133
34869748-8	2021	There was no significant difference in the intracellular reactive oxygen species levels in any group after IVM, but the 1 and 10 ng/mL NT-4 treatment groups showed a significant increase in the intracellular glutathione levels compared to the control.	Oxygen	66-72	neurotrophin 4	Sus scrofa	135-139
34827665-6	2021	GAA could protect H9c2 cells against ferroptotic cell death caused by these ferroptosis inducers by decreasing the production of malondialdehyde and reactive oxygen species, chelating iron content, and downregulating mRNA levels of Ptgs2.	Oxygen	158-164	alpha glucosidase	Rattus norvegicus	0-3
34827665-7	2021	GAA could prevent oxygen-glucose deprivation/reperfusion-induced cell death and lipid peroxidation in the cardiomyocytes.	Oxygen	18-24	alpha glucosidase	Rattus norvegicus	0-3
34606937-6	2021	Furthermore, the hydrogen peroxide generated by GOx as well as overexpressed in tumor can be decomposed by CAT and continuously generate oxygen, which further enhance the efficacy of oxygen-dependent starvation therapy and photodynamic therapy.	Oxygen	183-189	hydroxyacid oxidase 1	Homo sapiens	48-51
7470468-4	1981	At a lower ionic strength, transitions are centered at 44, 61, 66, 70, 78, and 83 degrees C. The 42--44 degrees C endothermic transition (the A transition) can be correlated with the modification of three electron-transport components or properties associated with photosystem II: (i) release of manganese from the membrane, (ii) the loss of O2 evolution with water as a donor, and (iii) a decrease in the redox potential of the hydroquinone-reducible cytochrome b-559.	Oxygen	342-344	mitochondrially encoded cytochrome b	Homo sapiens	452-464
34672612-4	2021	We demonstrate that the Sigma5 GB is Ti-rich and poor in Sr. We investigate possible effects on the variation in the atomic electrostatic field, including oxygen vacancies, Ti-valence change, and accumulation of cations.	Oxygen	155-161	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	24-30
35220189-3	2022	The optimized Ni3S2-FeS/NF-2 electrode realized ultra-high efficiency for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER).	Oxygen	74-80	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	24-28
35543151-5	2022	Whole genome gene expression profiling was performed in TRAP1-silenced HCT116 cells exposed to hypoxia to establish the role of TRAP1 in adaptive responses to oxygen deprivation.	Oxygen	159-165	TNF receptor associated protein 1	Homo sapiens	128-133
6174028-4	1981	A change of the composition of the wastes to nitrogenous-organic (COD 1,200 mg O2/l) caused a drop in the efficiency of nitrification to 24 mg N/l/h and the subsequent introduction of a three-step system.	Oxygen	79-81	retinitis pigmentosa GTPase regulator	Homo sapiens	66-71
35131555-9	2022	The multivariable analysis showed that preoperative oxygen desaturation index (ODI) >=30 events per hour {adjusted hazard ratio (aHR) 1.63 (95% confidence interval (CI): 1.05-2.53)}, and cumulative time spent during sleep with oxygen saturation below 80% (CT80) >=10 min {aHR 1.79 (95% CI: 1.28-2.50)} were independent predictors of 30-day postoperative cardiovascular events.	Oxygen	52-58	piwi like RNA-mediated gene silencing 2	Homo sapiens	256-260
34618466-1	2021	We report a highly efficient and selective catalytic system, ABNO (9-azabicyclo-(3.3.1)nonane N-oxyl)/HNO3, for the aerobic oxidation of substituted furans to cis-2-ene-1,4-diones under mild reaction conditions using oxygen as the oxidant.	Oxygen	217-223	suppressor of cytokine signaling 2	Homo sapiens	159-164
34732698-5	2021	On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy.	Oxygen	266-272	mechanistic target of rapamycin kinase	Rattus norvegicus	33-37
7248568-0	1981	Activation of oxygen metabolism in polymorphonuclear leucocytes : activity of soluble and membrane bound NADPH and NADH oxidases.	Oxygen	14-20	2,4-dienoyl-CoA reductase 1	Homo sapiens	105-110
34732698-5	2021	On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy.	Oxygen	266-272	mechanistic target of rapamycin kinase	Rattus norvegicus	227-231
34725089-2	2021	In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884.	Oxygen	306-312	cystathionine gamma-lyase	Homo sapiens	220-245
34725089-2	2021	In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884.	Oxygen	306-312	cystathionine gamma-lyase	Homo sapiens	247-250
35150953-3	2022	Benefitted from the optimized electronic configuration, hierarchical structure and abundant active sites, the Mo,Fe-NiCoPx/NF electrode has shown competitive oxygen evolution reaction (n10 = 197 mV) and hydrogen evolution reaction performance (n10 = 99 mV) when the current density is 10 mA cm-2 in 1 M KOH solution.	Oxygen	158-164	neurofascin	Homo sapiens	123-125
35338668-4	2022	The O2 - -generating system in leukocytes is consisted of membrane cytochrome b 558 protein (a complex of p22-phox and gp91-phox proteins) and cytosolic p40-phox, p47-phox and p67-phox proteins.	Oxygen	4-6	cytochrome b-245 beta chain	Homo sapiens	119-128
35338668-4	2022	The O2 - -generating system in leukocytes is consisted of membrane cytochrome b 558 protein (a complex of p22-phox and gp91-phox proteins) and cytosolic p40-phox, p47-phox and p67-phox proteins.	Oxygen	4-6	neutrophil cytosolic factor 1	Homo sapiens	163-171
35338668-9	2022	These results suggested that L-theanine brings about remarkable accumulation of cytochrome b 558 protein via up-regulating the transcription of gp91-phox gene during leukocyte differentiation, resulting in marked augmentation of the O2 - -generating ability, which is one of the most important functions of leukocytes responsible for the innate immune system.	Oxygen	233-235	cytochrome b-245 beta chain	Homo sapiens	144-153
34782552-5	2022	In mouse models of spinal cord injury, Hv1 deficiency ameliorates microglia activation, resulting in alleviated production of reactive oxygen species and pro-inflammatory cytokines.	Oxygen	135-141	hepatitis virus (MHV-2) susceptibility	Mus musculus	39-42
34782552-8	2022	We discuss recent studies on the roles of Hv1 activation in pathophysiological activities of microglia, such as production of NOX-dependent reactive oxygen species, microglia polarization, and tissue acidosis, particularly in the context of spinal cord injury.	Oxygen	149-155	hepatitis virus (MHV-2) susceptibility	Mus musculus	42-45
35294968-5	2022	OGD-induced generation of O2   - or H2O2 enhanced autophagy by inducing the expression of Activating Molecule in BECN1-Regulated Autophagy Protein 1 (Ambra1) and Beclin1 in both cell types.	Oxygen	26-28	beclin 1	Homo sapiens	162-169
34182642-5	2021	Spin-trapping electron paramagnetic resonance measurements and quenching experiments demonstrated that O2-, OH, 1O2 and h+ contributed to TCH degradation.	Oxygen	103-106	spindlin 1	Homo sapiens	0-4
34171587-4	2021	Air pollutants (particulate matter, oxygen radicals, hydrocarbons and volatile organic compounds) and water pollutants (metals and organic chemicals) can also intensify Th1/Th17 immune response and could exacerbate SARS-CoV-2 related respiratory distress and failure.	Oxygen	36-42	negative elongation factor complex member C/D	Homo sapiens	169-172
6450276-6	1981	The development of RLF was associated with prolonged oxygen exposure and the presence of bacterial sepsis.	Oxygen	53-59	RLF zinc finger	Homo sapiens	19-22
34175611-8	2021	The results revealed that ship traffic volume (STV) exerted indirect effects on PFAA distribution between solid and dissolved phases by influencing dissolved oxygen, total suspended solid concentration, clay and sand contents, and median diameter.	Oxygen	158-164	inositol polyphosphate-5-phosphatase D	Homo sapiens	26-30
35617319-8	2022	The calculated distances between the heme oxygen and the dioxin carbon nearest to the oxygen, reflecting the hydroxylating potential of CYP1A2, were higher than in other pCYP1 enzymes.	Oxygen	42-48	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	136-142
35617319-8	2022	The calculated distances between the heme oxygen and the dioxin carbon nearest to the oxygen, reflecting the hydroxylating potential of CYP1A2, were higher than in other pCYP1 enzymes.	Oxygen	86-92	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	136-142
7402127-2	1980	The electron transport chain (ETC) of Pseudomonas thermophila K-2 was examined by the amperometric determination of O2 uptake by the preparations of membranes isolated by ultracentrifugation at 14,000 g. Amytal and cyanide were found to inhibit endogenous respiration of membranes from freshly grown cells.	Oxygen	116-118	RBPJ pseudogene 3	Homo sapiens	62-65
35605218-10	2022	CONCLUSION: Our study has made it clear that Dex inhibited the upregulation of HIF-1alpha in diabetic MIR-induced ALI, and thus protect lung functions by quenching the accumulation of oxygen radical and reducing lung inflammatory response.	Oxygen	184-190	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	79-89
35452214-8	2022	This antitumorigenic potential of FA-CD-(PTX-GOx) could be attributed to the enhanced intratumoral reactive oxygen species generation following glucose depletion by GOx that has been facilitated by the chemotherapeutic efficacy of PTX resulting in the efficient killing of cancer cells.	Oxygen	108-114	FA complementation group D2	Homo sapiens	34-39
35452214-8	2022	This antitumorigenic potential of FA-CD-(PTX-GOx) could be attributed to the enhanced intratumoral reactive oxygen species generation following glucose depletion by GOx that has been facilitated by the chemotherapeutic efficacy of PTX resulting in the efficient killing of cancer cells.	Oxygen	108-114	hydroxyacid oxidase 1	Homo sapiens	45-48
35452214-8	2022	This antitumorigenic potential of FA-CD-(PTX-GOx) could be attributed to the enhanced intratumoral reactive oxygen species generation following glucose depletion by GOx that has been facilitated by the chemotherapeutic efficacy of PTX resulting in the efficient killing of cancer cells.	Oxygen	108-114	hydroxyacid oxidase 1	Homo sapiens	165-168
34309081-8	2021	The ATP content and down-regulation of HIF-1a expression after preservation of the liver graft by the oxygenated perfluorocarbon emulsion suggested that advantage of adequate oxygen supply for adequate time.	Oxygen	175-181	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	39-45
34769136-6	2021	The inhibition of Crif1 mRNA in mIMCD cells reduced oxygen consumption and membrane potential.	Oxygen	52-58	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	18-23
6771758-1	1980	Much evidence now suggests that superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) may be a major intracellular protective enzyme against oxygen toxicity by catalyzing the removal of the superoxide radical.	Oxygen	160-166	thioredoxin reductase 1	Homo sapiens	76-90
34686334-5	2021	p38 activation reduces the levels of wound-induced reactive oxygen species in the cells around the wound, limiting wound size.	Oxygen	60-66	p38b MAP kinase	Drosophila melanogaster	0-3
34371008-4	2021	High glucose concentrations stimulated reactive oxygen species production through NADPH oxidase activation, decreased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and reduced deacetylase sirtuin 1 (SIRT1) protein levels and activity.	Oxygen	48-54	sirtuin 1	Homo sapiens	215-224
34371008-4	2021	High glucose concentrations stimulated reactive oxygen species production through NADPH oxidase activation, decreased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and reduced deacetylase sirtuin 1 (SIRT1) protein levels and activity.	Oxygen	48-54	sirtuin 1	Homo sapiens	226-231
35567431-0	2022	Changes to culture pH and dissolved oxygen can enhance CAR T-cell generation and differentiation.	Oxygen	36-42	nuclear receptor subfamily 1 group I member 3	Homo sapiens	55-58
35567431-2	2022	Understanding how key culture conditions such as pH and dissolved oxygen (DO) affect CAR T-cell generation and function is important in developing better CAR-T manufacturing processes and CAR T-cell therapies for patients.	Oxygen	66-72	nuclear receptor subfamily 1 group I member 3	Homo sapiens	85-88
35567431-2	2022	Understanding how key culture conditions such as pH and dissolved oxygen (DO) affect CAR T-cell generation and function is important in developing better CAR-T manufacturing processes and CAR T-cell therapies for patients.	Oxygen	66-72	nuclear receptor subfamily 1 group I member 3	Homo sapiens	154-157
6155814-5	1980	15-hydroxyprostaglandin dehydrogenase (PGDH) was inhibited by 83% after O2 exposure, as measured by an in vitro enzyme assay.	Oxygen	72-74	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Cavia porcellus	39-43
35577083-11	2022	The model was fit to experimental data with assorted H2O2 supply profiles and validated, and Root Mean Square Error (RMSE) below 0.009 mM, 0.42 mM, and 0.127 mM were obtained for TOC, H2O2 and O2, respectively.	Oxygen	193-195	rhomboid 5 homolog 2	Homo sapiens	179-182
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	SUMO specific peptidase 3	Homo sapiens	86-91
34399025-8	2021	A CSD search indicated the frequent and consistent occurrence of this interaction and its role dictating the syn conformation of azide and oxygen in molecules where these groups are separated by 2-4 bonds.	Oxygen	139-145	synemin	Homo sapiens	109-112
34693402-4	2021	Principal component analysis identified ring strain and the electron density on the carbonyl oxygen (based on structures optimized by means of omegaB97X-D/6311+G(2df,2p) calculations) as the two key contributors to fast ring-opening metathesis of the bicyclo(4.2.0)oct-6-enes; whereas the dipole moment, conjugation, and energy of the highest occupied molecular orbital had little to no effect on the reaction rate.	Oxygen	93-99	POU class 3 homeobox 1	Homo sapiens	265-270
34280396-9	2021	The results of our study indicated that visfatin-induced reductions in endothelium-dependent relaxations of rat isolated small resistance arteries are mediated by oxygen free radicals and a reduction in nitric oxide (NO) bioavailability.	Oxygen	163-169	nicotinamide phosphoribosyltransferase	Rattus norvegicus	40-48
34608585-8	2022	Pharmacological inhibition of MCs targeting tyrosine kinase (TK) reduces the generation of reactive oxygen species and normalizes catalase, and gluthation S-transferase activities to their physiological levels.	Oxygen	100-106	TXK tyrosine kinase	Homo sapiens	44-59
34608585-8	2022	Pharmacological inhibition of MCs targeting tyrosine kinase (TK) reduces the generation of reactive oxygen species and normalizes catalase, and gluthation S-transferase activities to their physiological levels.	Oxygen	100-106	TXK tyrosine kinase	Homo sapiens	61-63
35628180-10	2022	SR-BI regulation was studied by exposing ECA and ECV to differential oxygen concentrations or shear stress.	Oxygen	69-75	scavenger receptor class B member 1	Homo sapiens	0-5
35526196-7	2022	RESULTS: In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa2+ and reactive oxygen species overload associated with a mitochondrial membrane depolarization, leading to reduced ATP production and apoptosis.	Oxygen	117-123	solute carrier family 8 member B1	Homo sapiens	87-91
35513433-7	2022	Furthermore, we demonstrated that increased (Cl-)i by CFTRinh-172 or CFTR knockout increased the phosphorylation of serum- and glucocorticoid-inducible protein kinase 1 (SGK1) and generation of intracellular reactive oxygen species in neutrophils, and promoted oxLDL-induced NET formation and pro-inflammatory cytokine production.	Oxygen	217-223	cystic fibrosis transmembrane conductance regulator	Mus musculus	69-73
6264767-2	1980	When challenged with phagocytosable particles or with membrane perturbing agents such as chemotactic factors, detergents, lectins and other ligands, granulocytes and mononuclear phagocytes undergo a dramatic increase of oxygen consumption which is associated with the production of superoxide anion (O-2), of hydrogen peroxide (H2O2) and of hydroxyl radical (OH.).	Oxygen	220-226	immunoglobulin kappa variable 1D-39	Homo sapiens	300-303
35446535-5	2022	The results indicate that the MR-CNTF used as a cathodic microporous layer can remarkably facilitate the oxygen transport and water management.	Oxygen	105-111	ciliary neurotrophic factor	Homo sapiens	33-37
34383986-5	2021	All the results are compared to the benzothiophene-fused analogues and show that the increased electronegativity of oxygen in the syn -fused derivatives leads to enhancement of the antiaromatic core causing greater paratropicity.	Oxygen	116-122	synemin	Homo sapiens	130-133
34593641-1	2021	Experiments have shown that the families of cuprate superconductors that have the largest transition temperature at optimal doping also have the largest oxygen hole content at that doping (D. Rybicki et al., Nat.	Oxygen	153-159	bromodomain containing 2	Homo sapiens	208-211
6990915-0	1980	Abnormal hemoglobin-oxygen affinity and surgical hemotherapy.	Oxygen	20-26	hemoglobin subunit gamma 2	Homo sapiens	0-19
34729313-5	2021	GOx maintains high enzymatic activity to catalyze glucose with assistant of oxygen to generate hydrogen peroxide (H2O2) as starvation therapy.	Oxygen	76-82	hydroxyacid oxidase 1	Homo sapiens	0-3
34383924-11	2021	Furthermore, decreased Shmt2 expression in MEF cells reduced cell proliferation, mitochondrial membrane potential, and oxygen consumption rate.	Oxygen	119-125	serine hydroxymethyltransferase 2 (mitochondrial)	Mus musculus	23-28
35474599-5	2022	Deactivated AMPK induces metabolic dysregulation, mitochondrial fragmentation, and reactive oxygen species formation, leading to the activation of the NLRP3 inflammasome.	Oxygen	92-98	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	12-16
7350931-0	1980	Methemoglobin reduction in red cells: effect of a high oxygen affinity hemoglobin.	Oxygen	55-61	hemoglobin subunit gamma 2	Homo sapiens	0-13
35344393-9	2022	Chemogenetic activation of the GsD by a designer drug (deschloroclozapine: DCZ; 0.01~0.1 mg/kg BW) in MC4R-expressing cells significantly increased oxygen consumption and locomotor activity.	Oxygen	148-154	melanocortin 4 receptor	Homo sapiens	102-106
7350931-1	1980	Erythrocytes from heterozygous carriers of the high oxygen affinity mutant hemoglobin, Hb Wood, demonstrate lower rates of methemoglobin reduction than normal human red cells when incubated in the in vitro system of Beutler and Baluda.	Oxygen	52-58	hemoglobin subunit gamma 2	Homo sapiens	123-136
35468040-6	2022	HFD-induced increase of beta-cell mitophagy is reduced by tfeb KO, leading to increased ROS and decreased mitochondrial complex activity or oxygen consumption in tfeb-KO islets.	Oxygen	140-146	transcription factor EB	Mus musculus	58-62
35468040-6	2022	HFD-induced increase of beta-cell mitophagy is reduced by tfeb KO, leading to increased ROS and decreased mitochondrial complex activity or oxygen consumption in tfeb-KO islets.	Oxygen	140-146	transcription factor EB	Mus musculus	162-166
468691-3	1979	Under these conditions exogenous insulin (0.3 U.kg-1) induced a further increase in oxygen uptake and in shivering intensity whereas a decrease in the fall of colonic temperature was observed.	Oxygen	84-90	insulin	Canis lupus familiaris	33-40
35446597-2	2022	Commercial N2 washout devices are usually based on indirect measurement of N2 concentration (CN2), by directly measuring either molar mass and O2 and CO2, or molar mass and CO2.	Oxygen	143-145	carnosine dipeptidase 2	Homo sapiens	93-96
263729-0	1979	Oxygen"s role in RLF refuted.	Oxygen	0-6	RLF zinc finger	Homo sapiens	17-20
35253953-8	2022	For membranes prepared with relatively higher GOx, oxygen-limited behavior is considered the source of diminished sensitivity at higher glucose levels.	Oxygen	51-57	hydroxyacid oxidase 1	Homo sapiens	46-49
35624763-0	2022	Thioredoxin-1 Ameliorates Oxygen-Induced Retinopathy in Newborn Mice through Modulation of Proinflammatory and Angiogenic Factors.	Oxygen	26-32	thioredoxin 1	Mus musculus	0-13
761116-2	1979	Hypoxia increased pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR) so that in each case inverse linear relationships were found with arterial oxygen saturation.	Oxygen	165-171	PVR cell adhesion molecule	Canis lupus familiaris	85-88
35489654-1	2022	The phagocyte NADPH oxidase (NOX2) is a key enzyme of the innate immune system generating superoxide anions (O2 -), precursors of reactive oxygen species.	Oxygen	109-113	cytochrome b-245 beta chain	Homo sapiens	29-33
761116-6	1979	Animals with low PVR responses showed the greatest arterial oxygen desaturation with hypoxia, whereas high responders showed least oxygen desaturation.	Oxygen	60-66	PVR cell adhesion molecule	Canis lupus familiaris	17-20
35468253-0	2022	Theory-Guided Regulation of FeN4 Spin State by Neighboring Cu Atoms for Enhanced Oxygen Reduction Electrocatalysis in Flexible Metal-Air Batteries.	Oxygen	81-87	spindlin 1	Homo sapiens	33-37
35459996-3	2022	In this system, the hydrogen is produced onboard while oxygen is carried in liquefied form (LOX) from the land in specially designed insulated storage vessels called dewars.	Oxygen	55-61	lysyl oxidase	Homo sapiens	92-95
35624674-9	2022	Interestingly, PPARdelta activation suppressed 6-OHDA-triggered generation of reactive oxygen species and lipid peroxides.	Oxygen	87-93	peroxisome proliferator activated receptor delta	Homo sapiens	15-24
35624674-11	2022	Taken together, these findings suggest that PPARdelta attenuates 6-OHDA-induced neurotoxicity by preventing intracellular iron accumulation, thereby suppressing iron overload-associated generation of reactive oxygen species and lipid peroxides, key mediators of ferroptotic cell death.	Oxygen	209-215	peroxisome proliferator activated receptor delta	Homo sapiens	44-53
33429-2	1978	The high oxygen affinity of fetal blood (P50 = 29 Torr at 37 degrees C, pH 7.4 and Pco2 = 40 Torr) decreases to an average adult value of 41 Torr within two weeks after birth, accompanied by an increase of DPG-concentration from 0.2 M/MHb4 to the average of 1.5 M/MHb4.	Oxygen	9-15	keratin 86	Mus musculus	235-239
35446939-0	2022	Prenatal Oxygen and Glucose Therapy Normalizes Insulin Secretion and Action in Growth Restricted Fetal Sheep.	Oxygen	9-15	LOC105613195	Ovis aries	47-54
35380039-2	2022	An important aspect of the PHM mechanism is the complete coupling of oxygen reduction to substrate hydroxylation, which implies no oxygen reactivity of the fully reduced enzyme in the absence of peptidyl substrates.	Oxygen	69-75	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	27-30
33429-2	1978	The high oxygen affinity of fetal blood (P50 = 29 Torr at 37 degrees C, pH 7.4 and Pco2 = 40 Torr) decreases to an average adult value of 41 Torr within two weeks after birth, accompanied by an increase of DPG-concentration from 0.2 M/MHb4 to the average of 1.5 M/MHb4.	Oxygen	9-15	keratin 86	Mus musculus	264-268
30131-1	1978	The oxygen affinity in the blood of adult Dorset sheep with HbB was studied by determining several oxygen equilibrium curves under different conditions of pH and PCO2 by a method that allowed strict control of pH, PCO2, and HCO3- concentration over the entire curve.	Oxygen	4-10	hemoglobin subunit beta	Ovis aries	60-63
35416740-19	2022	Oxygen therapy may well lead to complete recovery when methemoglobin levels do not exceed 30% in asymptomatic and 20% in mildly symptomatic patients.	Oxygen	0-6	hemoglobin subunit gamma 2	Homo sapiens	55-68
35416745-3	2022	Browning, a physiological response that impacts organoleptic properties and deters consumer purchase of fresh-cut fresh produce, is mainly a result of enzymatic reaction of phenolic compounds with oxygen catalyzed by polyphenol oxidase (PPO), a decapper enzyme.	Oxygen	197-203	polyphenol oxidase, chloroplastic	Malus domestica	217-235
35416745-3	2022	Browning, a physiological response that impacts organoleptic properties and deters consumer purchase of fresh-cut fresh produce, is mainly a result of enzymatic reaction of phenolic compounds with oxygen catalyzed by polyphenol oxidase (PPO), a decapper enzyme.	Oxygen	197-203	polyphenol oxidase, chloroplastic	Malus domestica	237-240
30131-1	1978	The oxygen affinity in the blood of adult Dorset sheep with HbB was studied by determining several oxygen equilibrium curves under different conditions of pH and PCO2 by a method that allowed strict control of pH, PCO2, and HCO3- concentration over the entire curve.	Oxygen	99-105	hemoglobin subunit beta	Ovis aries	60-63
678250-6	1978	Oxidized and reduced glutathione protected SDH against hyperbaric oxygen inactivation.	Oxygen	66-72	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	43-46
35348331-5	2022	GOx could effectively consume oxygen and catalyzed glucose into gluconic acid and hydrogen peroxide.	Oxygen	30-36	hydroxyacid oxidase 1	Homo sapiens	0-3
35463129-2	2022	Neuroglobin is an oxygen-binding protein mainly expressed in brain neurons.	Oxygen	18-24	neuroglobin	Homo sapiens	0-11
678250-7	1978	It is concluded that glutathione can stimulate oxygen consumption and maintain SDH activity after exposure to hyperbaric oxygen by increasing succinate formation through the glutathione-succinate shunt.	Oxygen	121-127	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	79-82
25065-4	1978	Chick-embryo heart cells grown in culture in 20% O(2) (in which they divide more slowly than in 5% O(2)) did exhibit greater poly(ADP-ribose) polymerase activity (+83%, P&lt;0.001) than when grown in 5% O(2).	Oxygen	49-53	poly(ADP-ribose) polymerase 1	Gallus gallus	125-152
35444554-0	2022	Setanaxib (GKT137831) Ameliorates Doxorubicin-Induced Cardiotoxicity by Inhibiting the NOX1/NOX4/Reactive Oxygen Species/MAPK Pathway.	Oxygen	106-112	NADPH oxidase 1	Rattus norvegicus	87-91
25065-4	1978	Chick-embryo heart cells grown in culture in 20% O(2) (in which they divide more slowly than in 5% O(2)) did exhibit greater poly(ADP-ribose) polymerase activity (+83%, P&lt;0.001) than when grown in 5% O(2).	Oxygen	99-103	poly(ADP-ribose) polymerase 1	Gallus gallus	125-152
35475886-9	2022	Conclusions: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.	Oxygen	89-95	CD44 molecule (Indian blood group)	Homo sapiens	43-47
25408-0	1978	Oxygen affinity of hemoglobins F and A partially oxidized to methemoglobin: influence of 2,3-diphosphoglycerate.	Oxygen	0-6	hemoglobin subunit gamma 2	Homo sapiens	61-74
35233951-3	2022	The V2 O3 /MnS catalyst shows a decent catalytic activity that is comparable to Pt/C toward the oxygen reduction reaction and acceptable toward oxygen evolution.	Oxygen	96-102	glycophorin E (MNS blood group)	Homo sapiens	11-14
35233951-3	2022	The V2 O3 /MnS catalyst shows a decent catalytic activity that is comparable to Pt/C toward the oxygen reduction reaction and acceptable toward oxygen evolution.	Oxygen	144-150	glycophorin E (MNS blood group)	Homo sapiens	11-14
35233951-4	2022	The extraordinary stability as well as the low cost set the V2 O3 /MnS among the best bifunctional oxygen electrocatalysts.	Oxygen	99-105	glycophorin E (MNS blood group)	Homo sapiens	67-70
737239-2	1978	When rings were stretched to initial lengths that result in a maximal contractile response for rings in that age group, the oxygen-induced contraction was 5.91 +/- 0.72 g/mm2 (+/-SEM, n = 18) in animals older than 135 days, 5.55 +/- 1.23 g/mm2 (n = 18) in animals between 111 and 130 days, and 3.85 +/- 0.75 g/mm2 (n = 19) in animals between 87 and 110 days.	Oxygen	124-130	PNMA family member 2	Homo sapiens	171-174
35277904-0	2022	The Decisive Role of Spin States and Spin Coupling in Dictating Selective O2 Adsorption in Chromium(II) Metal-Organic Frameworks.	Oxygen	74-76	spindlin 1	Homo sapiens	21-25
35277904-0	2022	The Decisive Role of Spin States and Spin Coupling in Dictating Selective O2 Adsorption in Chromium(II) Metal-Organic Frameworks.	Oxygen	74-76	spindlin 1	Homo sapiens	37-41
35277904-2	2022	The image depicts how a mixture of atmospheric gases such as CO2 , H2 , N2 and O2 can be selectively separated using a Cr metal-organic framework where spin state and spin coupling play a crucial role.	Oxygen	79-81	spindlin 1	Homo sapiens	152-156
35277904-2	2022	The image depicts how a mixture of atmospheric gases such as CO2 , H2 , N2 and O2 can be selectively separated using a Cr metal-organic framework where spin state and spin coupling play a crucial role.	Oxygen	79-81	spindlin 1	Homo sapiens	167-171
737239-2	1978	When rings were stretched to initial lengths that result in a maximal contractile response for rings in that age group, the oxygen-induced contraction was 5.91 +/- 0.72 g/mm2 (+/-SEM, n = 18) in animals older than 135 days, 5.55 +/- 1.23 g/mm2 (n = 18) in animals between 111 and 130 days, and 3.85 +/- 0.75 g/mm2 (n = 19) in animals between 87 and 110 days.	Oxygen	124-130	PNMA family member 2	Homo sapiens	240-243
35408970-0	2022	CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells.	Oxygen	32-38	CD44 molecule (Indian blood group)	Homo sapiens	0-4
737239-2	1978	When rings were stretched to initial lengths that result in a maximal contractile response for rings in that age group, the oxygen-induced contraction was 5.91 +/- 0.72 g/mm2 (+/-SEM, n = 18) in animals older than 135 days, 5.55 +/- 1.23 g/mm2 (n = 18) in animals between 111 and 130 days, and 3.85 +/- 0.75 g/mm2 (n = 19) in animals between 87 and 110 days.	Oxygen	124-130	PNMA family member 2	Homo sapiens	240-243
35401225-7	2022	In vitro, it was also confirmed that alpha-asaronol increased GLT-1 expression and recruitment of the PPARgamma coactivator PCG-1a in astrocytes under oxygen and glucose deprivation (OGD) conditions.	Oxygen	151-157	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	102-111
662882-0	1978	Myocardial oxygen-supply during hemodilution with stroma-free hemoglobin and methemoglobin solutions.	Oxygen	11-17	hemoglobin subunit gamma 2	Homo sapiens	77-90
597496-2	1977	The infrared spectra in the 1600-1800 cm-1 region clearly show the existence of a coordination interaction between the C-9 ketone oxygen function of one molecule and the central magnesium atom of another molecule.	Oxygen	130-136	complement C9	Homo sapiens	119-122
35147254-0	2022	The Spin Modulation Stimulated Efficient Electrocatalytic Oxygen Evolution Reaction over LaCoO3 Perovskite.	Oxygen	58-64	spindlin 1	Homo sapiens	4-8
34487347-7	2021	Across all treatment groups, left pulmonary artery blood flow and oxygen delivery were negatively correlated with SFTP-B mRNA and protein expression in late gestation.	Oxygen	66-72	pulmonary surfactant-associated protein B	Ovis aries	114-120
848715-1	1977	The TM3 Gas differentiator, a simple device introduced to differentiate between nitrous oxide and oxygen, was found to be capable of positively distinguishing between these gases when only they were known to be present.	Oxygen	98-104	tropomyosin 3	Homo sapiens	4-7
34400216-17	2021	Moreover, AMPD3 significantly reduced myotube mitochondrial protein synthesis rates (-55%), basal ATP synthase-dependent (-13%), and maximal uncoupled oxygen consumption (-15%).	Oxygen	151-157	adenosine monophosphate deaminase 3	Mus musculus	10-15
35051861-0	2022	Protective role of activating PPARgamma in advanced glycation end products-induced impairment of coronary artery vasodilation via inhibiting p38 phosphorylation and reactive oxygen species production.	Oxygen	174-180	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-39
35015384-8	2022	In addition, we discovered that LPS-induced downregulation of VE-cadherin and high production of reactive oxygen species were significantly attenuated upon IL10-eM exposure.	Oxygen	106-112	interleukin 10	Homo sapiens	156-163
795666-3	1976	During oxygen adaptation of yeast pre-grown on 0.3% glucose under anaerobic conditions catalase A is formed via a heme-less precursor, probably the apomonomer of the protein, and a heme-containing intermediate.	Oxygen	7-13	catalase A	Saccharomyces cerevisiae S288C	87-97
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	NAD(P)H dehydrogenase, quinone 1	Mus musculus	351-355
34371143-6	2021	Further studies in rat primary neuron-glial cultures showed that increased mitochondrial O2-, specifically in neurons, was sufficient to upregulate GFAP.	Oxygen	89-92	glial fibrillary acidic protein	Rattus norvegicus	148-152
34371143-7	2021	These results suggest that neuron-specific mitochondrial O2- is sufficient to drive a complex and catastrophic epileptic phenotype and highlights the ability of SOD2 to act in a cell-nonautonomous manner to influence an astrocytic response.	Oxygen	57-60	superoxide dismutase 2	Rattus norvegicus	161-165
34332338-1	2021	TMEM180, a novel colon cancer-specific protein with a 12-transmembrane topology, is upregulated at low oxygen.	Oxygen	103-109	major facilitator superfamily domain containing 13A	Homo sapiens	0-7
974115-6	1976	We followed the reaction of the reduced proteins to yield the oxyderivatives and measured the rate constants of the oxygenation process k reduced methemoglobin + O2 = 2.6 +/- 0.6-10(7) M-1-S-1 and k myoglobin + O2 = 1.8 +/- 0.2-10(7) M-1-S-1, all the rate constants were measured at pH = 6.8, I = 0.004, T = 22 +/- 2 degrees C. The high rate constant for reduced methemoglobin indicates that one-site-reduced methemoglobin is probably in the R state, as predicted for methemoglobin from X-ray analysis.	Oxygen	162-164	hemoglobin subunit gamma 2	Homo sapiens	146-159
974115-6	1976	We followed the reaction of the reduced proteins to yield the oxyderivatives and measured the rate constants of the oxygenation process k reduced methemoglobin + O2 = 2.6 +/- 0.6-10(7) M-1-S-1 and k myoglobin + O2 = 1.8 +/- 0.2-10(7) M-1-S-1, all the rate constants were measured at pH = 6.8, I = 0.004, T = 22 +/- 2 degrees C. The high rate constant for reduced methemoglobin indicates that one-site-reduced methemoglobin is probably in the R state, as predicted for methemoglobin from X-ray analysis.	Oxygen	162-164	hemoglobin subunit gamma 2	Homo sapiens	363-376
34581980-4	2021	The results showed that miR-149-5p was significantly downregulated in brain tissues of rats subjected to middle cerebral artery occlusion (MCAO) and primary cortical neurons subject to oxygen and glucose deprivation (OGD).	Oxygen	185-191	microRNA 149	Rattus norvegicus	24-31
35156389-9	2022	At multivariable analysis, TAPSE/PASP ratio remained a predictor of in-hospital death after adjustments for age, oxygen partial pressure at arterial gas analysis/fraction of inspired oxygen, left ventricular ejection fraction, and computed tomography lung score.	Oxygen	113-119	carboxypeptidase B1	Homo sapiens	33-37
35156389-9	2022	At multivariable analysis, TAPSE/PASP ratio remained a predictor of in-hospital death after adjustments for age, oxygen partial pressure at arterial gas analysis/fraction of inspired oxygen, left ventricular ejection fraction, and computed tomography lung score.	Oxygen	183-189	carboxypeptidase B1	Homo sapiens	33-37
974115-6	1976	We followed the reaction of the reduced proteins to yield the oxyderivatives and measured the rate constants of the oxygenation process k reduced methemoglobin + O2 = 2.6 +/- 0.6-10(7) M-1-S-1 and k myoglobin + O2 = 1.8 +/- 0.2-10(7) M-1-S-1, all the rate constants were measured at pH = 6.8, I = 0.004, T = 22 +/- 2 degrees C. The high rate constant for reduced methemoglobin indicates that one-site-reduced methemoglobin is probably in the R state, as predicted for methemoglobin from X-ray analysis.	Oxygen	162-164	hemoglobin subunit gamma 2	Homo sapiens	363-376
35221846-5	2022	The increases in the AGE-RAGE stress would elevate the expression and production of atherogenic factors, including reactive oxygen species, nuclear factor-kappa B, cytokines, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial leukocyte adhesion molecules, monocyte chemoattractant protein-1, granulocyte-macrophage colony-stimulating factor, and growth factors.	Oxygen	124-130	advanced glycosylation end-product specific receptor	Homo sapiens	25-29
34346541-3	2021	Active oxygen species (O 2 - , O 2 2 - and O 2 - ) at the anode surface effectively dehydrogenate ethane to ethylene, but O - species tend to induce deep oxidation.	Oxygen	7-13	immunoglobulin kappa variable 1D-39	Homo sapiens	23-46
34482701-0	2021	Pericardial Adipose Tissue-Derived Leptin Promotes Myocardial Apoptosis in High-Fat Diet-Induced Obese Rats Through Janus Kinase 2/Reactive Oxygen Species/Na+/K+-ATPase Signaling Pathway.	Oxygen	140-146	Janus kinase 2	Rattus norvegicus	116-130
34621741-6	2021	Our results demonstrate severe hypoxic stress (0.1% oxygen) caused ATM auto-phosphorylation and activation (pS1981), H3K9me3, and elevated both Suv39H1 and Tip60 protein levels in FTC133 and HCT116 cell lines.	Oxygen	52-58	lysine acetyltransferase 5	Homo sapiens	156-161
35110412-5	2022	G6PD mutant melanomas exhibited increased levels of reactive oxygen species, decreased NADPH levels, and depleted glutathione as compared to control melanomas.	Oxygen	61-67	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
974115-6	1976	We followed the reaction of the reduced proteins to yield the oxyderivatives and measured the rate constants of the oxygenation process k reduced methemoglobin + O2 = 2.6 +/- 0.6-10(7) M-1-S-1 and k myoglobin + O2 = 1.8 +/- 0.2-10(7) M-1-S-1, all the rate constants were measured at pH = 6.8, I = 0.004, T = 22 +/- 2 degrees C. The high rate constant for reduced methemoglobin indicates that one-site-reduced methemoglobin is probably in the R state, as predicted for methemoglobin from X-ray analysis.	Oxygen	162-164	hemoglobin subunit gamma 2	Homo sapiens	363-376
974115-6	1976	We followed the reaction of the reduced proteins to yield the oxyderivatives and measured the rate constants of the oxygenation process k reduced methemoglobin + O2 = 2.6 +/- 0.6-10(7) M-1-S-1 and k myoglobin + O2 = 1.8 +/- 0.2-10(7) M-1-S-1, all the rate constants were measured at pH = 6.8, I = 0.004, T = 22 +/- 2 degrees C. The high rate constant for reduced methemoglobin indicates that one-site-reduced methemoglobin is probably in the R state, as predicted for methemoglobin from X-ray analysis.	Oxygen	211-213	hemoglobin subunit gamma 2	Homo sapiens	146-159
793463-5	1976	After the introduction of CPAP it was possible to decrease the enviromental oxygen concentration and both patients survived.	Oxygen	76-82	centromere protein J	Homo sapiens	26-30
35064691-6	2022	Further study revealed that the inhibition of MAT2A affected osteoclast differentiation mainly by suppressing crucial transcription factors and reactive oxygen species induced by RANKL.	Oxygen	153-159	TNF superfamily member 11	Homo sapiens	179-184
34557327-8	2021	H2-TPR points to a higher surface density of oxygen vacancy (Ov) due to Ni substitution.	Oxygen	45-51	translocated promoter region, nuclear basket protein	Homo sapiens	3-6
34544605-5	2022	O2 enters mammalian Mb and the alpha and beta subunits of human HbA through a channel created by upward and outward rotation of the distal His at the E7 helical position, is non-covalently captured in the interior of the distal cavity, and then internally forms a bond with the heme Fe(II) atom.	Oxygen	0-2	keratin 90, pseudogene	Homo sapiens	64-67
28309007-1	1976	Oxygen consumption at 25 C was measured continously throughout the egg stage of Leptopterna dolobrata (more than 9 months).The rate of O2-uptake (mul O2/100 eggs   1 h) is low in freshly laid eggs.	Oxygen	0-6	immunoglobulin kappa variable 1D-39	Homo sapiens	150-167
34571764-2	2021	Hence, we investigated the effect of environmental hypoxia and immune cell-specific deletion of oxygen sensor prolyl hydroxylase (PHD) 1 in a Crohn"s like ileitis mouse model.	Oxygen	96-102	egl-9 family hypoxia-inducible factor 2	Mus musculus	110-136
34510075-0	2022	Ex Vivo Normothermic Preservation of Amputated Limbs with a Hemoglobin-Based Oxygen Carrier (HBOC-201) Perfusate.	Oxygen	77-83	HGB	Sus scrofa	60-70
34510075-3	2022	To avoid limitations associated with use of blood-based products, we evaluated the feasibility of EVNLP utilizing a polymerized Hemoglobin-Based Oxygen Carrier-201 (HBOC-201).	Oxygen	145-151	HGB	Sus scrofa	128-138
28309007-1	1976	Oxygen consumption at 25 C was measured continously throughout the egg stage of Leptopterna dolobrata (more than 9 months).The rate of O2-uptake (mul O2/100 eggs   1 h) is low in freshly laid eggs.	Oxygen	135-137	immunoglobulin kappa variable 1D-39	Homo sapiens	150-167
35088561-8	2022	Mfn2, a target of miR-195, was found to be downregulated and was associated with increased mitochondrial production of reactive oxygen species during beta-cell dedifferentiation.	Oxygen	128-134	microRNA 195a	Mus musculus	18-25
34089891-5	2021	In every case a carbonyl or hydroxyl oxygen of the inhibitor is H-bonded to Tyr58 in subunit SdhD and Trp173 in subunit SdhB.	Oxygen	37-43	succinate dehydrogenase complex subunit D	Homo sapiens	93-97
2112-1	1976	The relationship between muscle surface pH (pHM) and the arterial-venous oxygen content difference (AVO2D) was studied in 4 patients undergoing reconstructive arterial surgery and in 6 patients undergoing acute normovolemic hemodilution.	Oxygen	73-79	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	44-47
34089891-5	2021	In every case a carbonyl or hydroxyl oxygen of the inhibitor is H-bonded to Tyr58 in subunit SdhD and Trp173 in subunit SdhB.	Oxygen	37-43	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	120-124
34306193-3	2021	It was revealed that lncRNA XIST was significantly upregulated in both a mouse cerebral infarction model induced by middle cerebral artery occlusion (MCAO) and an activated microglial model induced by oxygen/glucose deprivation (OGD).	Oxygen	201-207	inactive X specific transcripts	Mus musculus	28-32
35099054-8	2022	CONCLUSIONS: Among the basic parameters assessed on admission to the temporary hospital, LDH activity turned out to be the most useful for assessing the need for CPAP/BPAP active oxygen therapy.	Oxygen	179-185	centromere protein J	Homo sapiens	162-171
1237867-2	1975	The mean value of O2-uptake in the liver, related to a blood flow of 110 ml/min - 100 g liver, amounted to 6.08 +/- 0.2 ml O2/min - 100 g liver (mean +/- S.E.M.).	Oxygen	18-20	immunoglobulin kappa variable 1D-39	Homo sapiens	123-137
34652413-6	2022	The uncoupling of CO2 and O2 exchange and enhanced AOX pathway capacity suggest a reduction in plant energy demand under warm nights (lower O2 consumption), alongside higher rates of CO2 release under prevailing growth temperature (due to a lack of downregulation of respiratory CO2 release).	Oxygen	140-142	acyl-CoA oxidase 1	Homo sapiens	51-54
34518647-7	2021	The results of this study elucidate the direct molecular mechanisms linking miR-26a/b-5p and Cox5a in cell death induced by oxygen tension, which may contribute to the identification of new therapeutic targets to modulate cardiac function under physiological and pathological conditions.	Oxygen	124-130	microRNA 26a	Rattus norvegicus	76-85
34420370-4	2021	Angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production were reduced by disruption of the cPLA2alpha or Cyp1b1 genes or by administration of the arachidonic acid metabolism inhibitor 5,8,11,14-eicosatetraynoic acid to cPLA2alpha+/+/Cyp1b1+/+ mice.	Oxygen	112-118	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	186-192
34420370-4	2021	Angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production were reduced by disruption of the cPLA2alpha or Cyp1b1 genes or by administration of the arachidonic acid metabolism inhibitor 5,8,11,14-eicosatetraynoic acid to cPLA2alpha+/+/Cyp1b1+/+ mice.	Oxygen	112-118	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	314-320
34362834-4	2021	However, the simultaneous absence of TLR7, 9, and 13 resulted in markedly increased susceptibility to cutaneous and systemic S. aureus infection concomitantly with decreased production of proinflammatory chemokines and cytokines, neutrophil recruitment to infection sites, and reduced production of reactive oxygen species.	Oxygen	308-314	toll-like receptor 7	Mus musculus	37-41
34385713-3	2021	Mechanistically, autoantibodies and interferon-alpha present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREMalpha to the glutathione peroxidase 4 (Gpx4, the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species.	Oxygen	340-346	interferon alpha	Mus musculus	36-52
35038866-0	2022	Enhancing Moisture and Electrochemical Stability of the Li5.5PS4.5Cl1.5 Electrolyte by Oxygen Doping.	Oxygen	87-93	LI5	Homo sapiens	56-59
35159460-5	2022	The amino nitrogen atom and carboxyl oxygen atom of the functional groups on the surface of the FNs were the main binding sites for the chelation of Ca(II).	Oxygen	37-43	carbonic anhydrase 2	Homo sapiens	149-155
35058442-11	2022	These results suggest a novel model of tumorigenesis, in which PGK1 switches between repressing autophagy-mediated cell death via PRAS40 and inducing autophagy through Beclin1 according to the environmental oxygen level.	Oxygen	207-213	beclin 1	Homo sapiens	168-175
1237867-3	1975	O2-uptake of the intestine was found to be 1.95 +/- 0.13 ml O2/min - 100 g tissue, related to a normal blood flow of 50 ml/min - 100 g tissue.	Oxygen	0-2	immunoglobulin kappa variable 1D-39	Homo sapiens	60-74
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	30-36	C-X-C motif chemokine receptor 4	Homo sapiens	162-167
34246992-5	2021	This is due to the formation of Cl2 - in seawater which could react with HO2  and prevent the formation of O2 -, thus inhibit the photo aging process of PP MPs under light irradiation.	Oxygen	107-111	endogenous retrovirus group W member 5	Homo sapiens	32-35
35386453-2	2022	Therefore, a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane (PFH)-cored liposome, with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397 (named PFH@LSLP) for sorafenib-resistant HCC treatment.	Oxygen	98-104	C-X-C motif chemokine receptor 4	Homo sapiens	162-167
239968-8	1975	O2- production at 0.2 mM and 0.02 mM NADPH by lysates from the granulocytes of two patients with chronic granulomatous disease was similar to O2- production by control lysates.	Oxygen	0-2	2,4-dienoyl-CoA reductase 1	Homo sapiens	37-42
35203414-0	2022	VEGF-Trap Modulates Retinal Inflammation in the Murine Oxygen-Induced Retinopathy (OIR) Model.	Oxygen	55-61	vascular endothelial growth factor A	Mus musculus	0-4
34456930-5	2021	MFN2 silencing also increased zymosan-induced nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinases inflammatory signal transduction, without affecting mitochondrial reactive oxygen species production.	Oxygen	222-228	mitofusin 2	Homo sapiens	0-4
35425220-0	2022	Fe/Co/N-C/graphene derived from Fe/ZIF-67/graphene oxide three dimensional frameworks as a remarkably efficient and stable catalyst for the oxygen reduction reaction.	Oxygen	140-146	general transcription factor IIE subunit 1	Homo sapiens	0-2
234927-3	1975	In 17/72 patients, simultaneous measurements of oxygen affinity for hemoglobin as characterized by P50 (oxygen tension at 50% O-2 saturation) corrected to in vivo arterial pH decreased from a mean of 26.4 to 25.2 mm Hg (p smaller than .01).	Oxygen	104-110	immunoglobulin kappa variable 1D-39	Homo sapiens	126-129
35425220-0	2022	Fe/Co/N-C/graphene derived from Fe/ZIF-67/graphene oxide three dimensional frameworks as a remarkably efficient and stable catalyst for the oxygen reduction reaction.	Oxygen	140-146	general transcription factor IIE subunit 1	Homo sapiens	32-34
35057399-3	2022	Elevated contents of impurities, especially Pb, Bi, and oxygen, which affect the hot workability of stainless steels, were detected.	Oxygen	56-62	alcohol dehydrogenase iron containing 1	Homo sapiens	81-84
34319739-2	2021	While these diterpenoids share a 5/7/6-trans-fused ring system (ABC-ring), the three-carbon substitutions at the C13- and C14-positions on the C-ring and appending oxygen functional groups differ among them, accounting for the disparate biological activities of these natural products.	Oxygen	164-170	homeobox C13	Homo sapiens	113-116
4406462-0	1974	Perinatal factors influencing the arterial oxygen tension in preterm infants with RDS while breathing 100 per cent oxygen.	Oxygen	43-49	peripherin 2	Homo sapiens	82-85
34443450-6	2021	KL had high carbon content but low oxygen and methoxyl contents compared to MWLs.	Oxygen	35-41	klotho	Homo sapiens	0-2
16592125-1	1973	Isolated mesophyll cells from leaves of plants that use the C(4) dicarboxylic acid pathway of CO(2) fixation have been used to demonstrate that oxaloacetic acid reduction to malic acid is coupled to the photochemical evolution of oxygen through the presumed production of NADPH.	Oxygen	230-236	2,4-dienoyl-CoA reductase 1	Homo sapiens	272-277
35023064-7	2022	To explain these reparative changes, we found that repair-promoting LI-rTMS patterns, but not ineffective ones, increased c-fos expression in Purkinje neurons, consistent with the production of reactive oxygen species by activated cryptochrome.	Oxygen	203-209	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
34440146-0	2021	Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions.	Oxygen	11-17	interleukin 17A	Mus musculus	91-97
4644767-0	1972	Relationship between extracellular and intracellular hydrogen ion concentrations and hemoglobin oxygen affinity in the blood of premature infants with RDS.	Oxygen	96-102	peripherin 2	Homo sapiens	151-154
34440146-0	2021	Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions.	Oxygen	11-17	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	102-108
34112437-1	2021	We designed a signal-on photoelectrochemical (PEC) immunoassay for the sensitive monitoring of prostate-specific antigen (PSA) based on the etching reaction of hydrogen peroxide (H2O2) toward oxygen/phosphorus co-doped graphitic C3N4/AgBr/MnO2 nanosheets (OP-g-C3N4/AgBr/MnO2).	Oxygen	192-198	basic transcription factor 3 pseudogene 11	Homo sapiens	256-260
34318540-10	2021	It was found that PPARgamma agonist rosiglitazone significantly protected DRG neurons against cell apoptosis and reactive oxygen species generation induced by paclitaxel administration.	Oxygen	122-128	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	18-27
34293347-1	2021	NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O2-), which has functions in both cell signaling and immune defense.	Oxygen	62-65	cytochrome b-245 beta chain	Homo sapiens	0-15
35370278-9	2022	O2 - production is likely stimulated in both vascular endothelium and smooth muscle, the former of which may be mediated by AhR activation.	Oxygen	0-4	aryl hydrocarbon receptor	Rattus norvegicus	124-127
35064188-6	2022	Furthermore, islets of the Senp2-betaKO mice exhibited enlarged mitochondria and lower oxygen consumption rates, accompanied by lower levels of S616 phosphorylated DRP1 (an active form of DRP1), a mitochondrial fission protein.	Oxygen	87-93	SUMO/sentrin specific peptidase 2	Mus musculus	27-32
34865027-16	2022	In addition, glucose-stimulated insulin secretion was reduced (P < 0.05) in IUGR lambs and only modestly improved (P < 0.05) in IUGR+O2.	Oxygen	133-135	LOC105613195	Ovis aries	32-39
34293347-1	2021	NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O2-), which has functions in both cell signaling and immune defense.	Oxygen	62-65	cytochrome b-245 beta chain	Homo sapiens	17-21
34293347-3	2021	NOX2 uniquely facilitates an oxidative burst, which is described by initially slow O2- production which increases over time.	Oxygen	83-86	cytochrome b-245 beta chain	Homo sapiens	0-4
4330577-0	1971	Spin-label studies of cooperative oxygen binding to hemoglobin.	Oxygen	34-40	spindlin 1	Homo sapiens	0-4
34293347-4	2021	The NOX2 oxidative burst is considered critical to immune defense because it enables expedited O2- production in response to infections.	Oxygen	95-98	cytochrome b-245 beta chain	Homo sapiens	4-8
34293347-7	2021	NOX2 autoactivation begins when active Rac triggers NOX2 activation and the subsequent production of O2-, which in turn activates redox-sensitive Rac.	Oxygen	101-104	cytochrome b-245 beta chain	Homo sapiens	0-4
34293347-7	2021	NOX2 autoactivation begins when active Rac triggers NOX2 activation and the subsequent production of O2-, which in turn activates redox-sensitive Rac.	Oxygen	101-104	cytochrome b-245 beta chain	Homo sapiens	52-56
4396525-0	1970	[Influence of alpha and beta receptor blockaders upon oxygen consumption of methemoglobin containing erythrocytes].	Oxygen	54-60	hemoglobin subunit gamma 2	Homo sapiens	76-89
4317171-0	1970	Spin-quenching by oxygen of a radiosensitizing nitroxide free radical in aqueous solution.	Oxygen	18-24	spindlin 1	Homo sapiens	0-4
16591779-2	1969	Evidence has now been obtained that cytochrome b(559) is photooxidized at -189 degrees C and that this photooxidation can be induced only by "short-wavelength" monochromatic light which activates the oxygen-evolving system in chloroplasts (photosystem II).	Oxygen	200-206	mitochondrially encoded cytochrome b	Homo sapiens	36-48
16657096-4	1969	The presence of cytochrome c and a small amount of a-type cytochrome is determined in these cells.Light-induced oxidation of cytochrome b(563) is eliminated by oxygen-induced oxidation, and oxygen-induced oxidation is greatly diminished under illumination.	Oxygen	160-166	mitochondrially encoded cytochrome b	Homo sapiens	125-137
16657096-4	1969	The presence of cytochrome c and a small amount of a-type cytochrome is determined in these cells.Light-induced oxidation of cytochrome b(563) is eliminated by oxygen-induced oxidation, and oxygen-induced oxidation is greatly diminished under illumination.	Oxygen	190-196	mitochondrially encoded cytochrome b	Homo sapiens	125-137
16657096-5	1969	Antimycin A diminishes the oxygen-induced oxidation of cytochrome b(563), but does not affect light-induced oxidation.	Oxygen	27-33	mitochondrially encoded cytochrome b	Homo sapiens	55-67
16657096-6	1969	In the aerobic state in the presence of 2-heptyl-4-hydroxyquinoline-N-oxide, cytochrome b(563) is reduced by illumination with far red light; this reduction is not inhibited by 3-(4"-chlorophenyl)-1,1-dimethylurea.A tentative scheme for the electron transfer system in chloroplasts, which involves a cyclic pathway via cytochrome b(563) and its interaction with oxygen, is proposed.	Oxygen	362-368	mitochondrially encoded cytochrome b	Homo sapiens	77-89
6048771-14	1967	The inhibitory effect of oxygen on ferrochelatase activity has been confirmed by spectrophotometric assay of porphyrin disappearance.	Oxygen	25-31	ferrochelatase	Homo sapiens	35-49
5965897-5	1966	There was a direct and significant relation between P(a, o2) and P(a, CO2) and the age of the lamb.3.	Oxygen	57-59	laminin subunit beta-3	Ovis aries	94-100
14022974-0	1962	Effect of oxytocin on oxygen exchange between maternal and fetal circulation at the time of cesarean section.	Oxygen	22-28	oxytocin/neurophysin I prepropeptide	Homo sapiens	10-18
13481249-5	1957	Maximal activity in negation of interference is associated with the presence of oxygen at the C-11 position of the steroid molecule.	Oxygen	80-86	RNA polymerase III subunit K	Homo sapiens	94-98
18111542-0	1948	Intracorpuscular methemoglobin formation and its relation to the rate of oxygen release.	Oxygen	73-79	hemoglobin subunit gamma 2	Homo sapiens	17-30
18912267-0	1948	Means of support for therapeutic oxygen cylinders type D-2.	Oxygen	33-39	immunoglobulin heavy diversity 2-15	Homo sapiens	55-58
19871691-6	1947	Deoxygnated hemoglobin in the dry state was partly converted to methemoglobin by even momentary contact with oxygen.	Oxygen	109-115	hemoglobin subunit gamma 2	Homo sapiens	64-77
20273702-0	1946	Steroids derived from bile acids; introduction of oxygen at C11.	Oxygen	50-56	RNA polymerase III subunit K	Homo sapiens	60-63
17775844-1	1945	The action of mushroom tyrosinase on the oxidation of the irritant principles of poison ivy and on related toxic compounds has been demonstrated by measuring oxygen consumption, color change, decrease in phenolic groups and reduction in dermatitis-producing properties of these compounds on human and guinea-pig skin.	Oxygen	158-164	tyrosinase	Homo sapiens	23-33
19868989-6	1925	The equilibrium between hemoglobin and methemoglobin in a mixture of blood and pneumococcus cellular substances may be shifted in either direction at will by regulation of the oxygen tension.	Oxygen	176-182	hemoglobin subunit gamma 2	Homo sapiens	39-52
33831420-11	2021	Increased hs-cTnI levels were only associated with oxygen administration duration (Spearman rho=0.38; p=0.017), but this association disappeared in the multivariate analysis.	Oxygen	51-57	troponin I3, cardiac type	Homo sapiens	13-17
33609831-4	2021	In period 10, compared to the control group (CK), the adsorption capacity of Cu and Zn increased by 72.00% and 44.55%, respectively, and the number of oxygen-containing functional groups -OH, -COOH and -C=O greatly increased.	Oxygen	151-157	cytidine/uridine monophosphate kinase 1	Homo sapiens	45-47
33495950-7	2021	Correlation analysis supported the assertion that the variability in oxygen and redox conditions caused changes in Fe, Mn, and OM content at the WSB.The finding from the field research provides useful information to stakeholders on how to improve the quality of freshwater management designs.	Oxygen	69-75	general transcription factor IIE subunit 1	Homo sapiens	115-117
34440664-0	2021	Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.	Oxygen	9-15	transient receptor potential cation channel, subfamily M, member 6	Rattus norvegicus	37-78
34372036-8	2021	The limited oxygen index (LOI) of the MNP@CBPs increased from 21.95 to 27.01%.	Oxygen	12-18	sushi repeat containing protein X-linked 2	Homo sapiens	42-46
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Oxygen	81-87	CDGSH iron sulfur domain 2	Homo sapiens	294-299
33495950-7	2021	Correlation analysis supported the assertion that the variability in oxygen and redox conditions caused changes in Fe, Mn, and OM content at the WSB.The finding from the field research provides useful information to stakeholders on how to improve the quality of freshwater management designs.	Oxygen	69-75	oncomodulin 2	Homo sapiens	127-129
34267521-3	2021	The functional role of TNIP2 in oxygen and glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury was evaluated using cell counting kit-8, terminal deoxynucleotidyl transferase dutp nick end labeling assay and enzyme-linked immunosorbent assay.	Oxygen	32-38	TNFAIP3 interacting protein 2	Mus musculus	23-28
33850550-9	2021	These effects were induced by the activation of the AMP-activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response.	Oxygen	260-266	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	52-80
34357341-2	2021	Progressively reducing ambient oxygen (O2) will initially limit maximum metabolic rate as a result of a hypoxemic state and ultimately lead to a time-limited, tolerance state supported by substrate-level phosphorylation when the O2 supply can no longer meet basic needs (standard metabolic rate, SMR).	Oxygen	31-37	LY6/PLAUR domain containing 4	Homo sapiens	296-299
34357341-2	2021	Progressively reducing ambient oxygen (O2) will initially limit maximum metabolic rate as a result of a hypoxemic state and ultimately lead to a time-limited, tolerance state supported by substrate-level phosphorylation when the O2 supply can no longer meet basic needs (standard metabolic rate, SMR).	Oxygen	39-41	LY6/PLAUR domain containing 4	Homo sapiens	296-299
34357341-2	2021	Progressively reducing ambient oxygen (O2) will initially limit maximum metabolic rate as a result of a hypoxemic state and ultimately lead to a time-limited, tolerance state supported by substrate-level phosphorylation when the O2 supply can no longer meet basic needs (standard metabolic rate, SMR).	Oxygen	229-231	LY6/PLAUR domain containing 4	Homo sapiens	296-299
33850550-9	2021	These effects were induced by the activation of the AMP-activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response.	Oxygen	260-266	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	82-86
33850550-9	2021	These effects were induced by the activation of the AMP-activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response.	Oxygen	260-266	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	148-152
33475200-9	2021	To account for the differences in oxygen affinity, Hill"s equations were used to translate partial pressure of oxygen to oxygen saturation for HbA, sickle hemoglobin, and fetal hemoglobin (HbF) separately.	Oxygen	111-117	sodium voltage-gated channel alpha subunit 2	Homo sapiens	143-146
34139681-0	2021	Ionic liquid-derived Fe, N, S, F multiple heteroatom-doped carbon materials for enhanced oxygen reduction reaction.	Oxygen	89-95	general transcription factor IIE subunit 1	Homo sapiens	21-23
34145762-3	2021	The in situ oxidized Fe-Co-O/Co@NC-mNS/NF exhibits excellent bifunctional properties by demanding only low overpotentials of 257 and 112 mV, respectively, for OER and HER at the current density of 10 mA cm-2 , with long-term durability, attributed to the existence of oxygen vacancies, higher specific surface area, increased electrochemical active surface area, and in situ generated new metal (oxyhydr)oxide phases.	Oxygen	268-274	neurofascin	Homo sapiens	39-41
33475200-9	2021	To account for the differences in oxygen affinity, Hill"s equations were used to translate partial pressure of oxygen to oxygen saturation for HbA, sickle hemoglobin, and fetal hemoglobin (HbF) separately.	Oxygen	111-117	sodium voltage-gated channel alpha subunit 2	Homo sapiens	143-146
34047722-0	2021	Early Goal-Directed Therapy With and Without Intermittent Superior Vena Cava Oxygen Saturation Monitoring in Pediatric Septic Shock: A Randomized Controlled Trial.	Oxygen	77-83	carbonic anhydrase 5A	Homo sapiens	72-76
34257653-16	2021	GSEA enrichment analysis showed the main enrichment being in KRAS activation, genes defining epithelial and mesenchymal transition (EMT), raised in response to the low oxygen level (hypoxia) gene and NF-kB in response to TNF.	Oxygen	168-174	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
34204517-7	2021	GLUT1 and GLUT3 were upregulated by low oxygen.	Oxygen	40-46	solute carrier family 2, facilitated glucose transporter member 3	Bos taurus	10-15
34201387-6	2021	We further showed that increases in intracellular Ca2+ and protein kinase C alpha activation are downstream of TRPV1 for NADPH oxidase 4 upregulation and reactive oxygen species formation.	Oxygen	163-169	protein kinase C, alpha	Rattus norvegicus	59-81
33904834-0	2021	Different regulation of IRE1alpha and eIF2alpha pathways by oxygen and insulin in ACH-3P trophoblast model.	Oxygen	60-66	eukaryotic translation initiation factor 2A	Homo sapiens	38-47
34164397-0	2021	Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2alpha/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells.	Oxygen	199-205	activating transcription factor 4	Homo sapiens	81-114
33904834-7	2021	Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively).	Oxygen	48-54	eukaryotic translation initiation factor 2A	Homo sapiens	183-192
33986256-0	2021	Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2.	Oxygen	11-17	SRY-box transcription factor 2	Homo sapiens	125-129
34140895-1	2021	A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway.	Oxygen	53-59	heme oxygenase 1	Rattus norvegicus	154-175
34140895-1	2021	A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway.	Oxygen	53-59	heme oxygenase 1	Rattus norvegicus	177-182
34054802-0	2021	Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation.	Oxygen	0-6	CD8a molecule	Homo sapiens	31-34
34158656-9	2021	Secretin attenuated blood-oxygen level-dependent activity (primary endpoint) in brain reward circuits during food cue tasks (significance level false discovery rate corrected at P = 0.05) (n = 14).	Oxygen	26-32	secretin	Homo sapiens	0-8
34306835-8	2021	Two mechanisms contributing to turnover stability were found: (i) replacement of methionine side chains prone to oxidative damage and (ii) the reduction of oxygen reactivity achieved by an improved balance of the individual reaction rates in the two CDH domains.	Oxygen	156-162	choline dehydrogenase	Homo sapiens	250-253
34925625-0	2021	CPAP senkt Notwendigkeit zur Intubation im Vergleich zur konventionellen O2-Gabe.	Oxygen	73-75	centromere protein J	Homo sapiens	0-4
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	Oxygen	208-210	immunoglobulin kappa variable 1D-39	Homo sapiens	109-120
34046674-0	2021	Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn"s disease: results of the HOT-REVA pilot study.	Oxygen	11-17	alcohol dehydrogenase iron containing 1	Homo sapiens	118-121
35429690-6	2022	With the beta increasing to 100%, the ratio of invalid H2O2 decomposition to produce O2 decreased to 22%, equal to 25% reduction compared to CK.	Oxygen	85-87	cytidine/uridine monophosphate kinase 1	Homo sapiens	141-143
33962950-6	2021	PRDX4 addiction is associated with increased reactive oxygen species, a DNA-PKcs-governed DNA damage response and radiosensitivity, which can be rescued by depletion of NOX4 or NADPH.	Oxygen	54-60	peroxiredoxin 4	Homo sapiens	0-5
35413564-5	2022	GR-derived iron (hydr)oxides can generate 33.8 muM of  OH upon 50 h exposure to dioxygen, which leads to 67% of oxidative degradation of TBP.	Oxygen	80-88	TATA-box binding protein	Homo sapiens	137-140
33956021-0	2021	A highly efficient Fe-Ni-S/NF hybrid electrode for promoting oxygen evolution performance.	Oxygen	61-67	neurofascin	Homo sapiens	27-29
35622073-4	2022	As a result of synergetic interactions among the hydroxides, rGO and NF, enhanced catalytic sites with improved charge transport between the electrode and electrolyte were perceived, resulting in significantly enhanced oxygen evolution reaction (OER) activity with low overpotentials of 270 and 320 mV at 100 and 500 mA cm-2, respectively, in a 1.0 M KOH aqueous electrolyte.	Oxygen	219-225	neurofascin	Homo sapiens	69-71
33950533-3	2021	Here we uncover that in preosteoblast cell line, lacking Lgr4 results in decreased osteogenic function along with reduced glucose consumption, glucose uptake, and lactate production in the presence of abundant oxygen, which is referred to as aerobic glycolysis.	Oxygen	210-216	leucine-rich repeat-containing G protein-coupled receptor 4	Mus musculus	57-61
35436474-1	2022	Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is a commonly used hypoglycemic agent in clinical practice; it inhibits reactive oxygen species-induced pancreatic beta-cell apoptosis.	Oxygen	144-150	glucagon-like peptide 1 receptor	Mus musculus	38-53
33571420-4	2021	Interestingly, IL-33 pretreatment promoted survival by inhibiting acute lung injury: levels of bronchoalveolar lavage proinflammatory cytokines and pulmonary edema were both reduced, with an associated increase in oxygen saturation.	Oxygen	214-220	interleukin 33	Mus musculus	15-20
35278950-6	2022	Characterization techniques such as N2 adsorption, XRD, SEM/TEM, XPS, H2-TPR, and in situ DRIFT were employed to investigate the mechanism of the improved oxygen resistance property of Ni-doped catalyst.	Oxygen	155-161	translocated promoter region, nuclear basket protein	Homo sapiens	73-76
33652070-2	2021	Abeta stimulates active oxygen species generation leading to oxidative stress and neural cell death.	Oxygen	24-30	amyloid beta precursor protein	Rattus norvegicus	0-5
35481673-7	2022	Furthermore, the spin selectivity suppresses the production of H2 O2 by-product and promotes the formation of ground state O2 molecules during the oxygen evolution reaction.	Oxygen	123-125	spindlin 1	Homo sapiens	17-21
35481673-7	2022	Furthermore, the spin selectivity suppresses the production of H2 O2 by-product and promotes the formation of ground state O2 molecules during the oxygen evolution reaction.	Oxygen	147-153	spindlin 1	Homo sapiens	17-21
35359221-6	2022	The results from cultured cardiomyocytes also proved that sRAGE attenuated myocardial apoptosis and autophagy through interacting with integrinbeta3 to activate Akt and STAT3 pathway during oxygen and glucose deprivation/reperfusion (OGD/R) treatment.	Oxygen	190-196	integrin beta 3	Mus musculus	135-148
33933165-0	2021	Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy.	Oxygen	137-143	interleukin 17A	Mus musculus	33-48
33491841-8	2021	The level of VASH1 was measured under different oxygen conditions by qPCR.	Oxygen	48-54	vasohibin 1	Homo sapiens	13-18
35560217-0	2022	Prenatal Oxygen and Glucose Therapy Normalizes Insulin Secretion and Action in Growth-Restricted Fetal Sheep.	Oxygen	9-15	LOC105613195	Ovis aries	47-54
35364736-4	2022	Hypoxia, or a lack of oxygen, is thought to cause enhanced synovial angiogenesis in RA, which is mediated by some of the hypoxia-inducible factors like vascular endothelial growth factor (VEGF).	Oxygen	22-28	vascular endothelial growth factor A	Mus musculus	152-186
33586163-9	2021	p62 build-up led to activation of the p62-Nrf2 axis and emergence of reactive oxygen species.	Oxygen	78-84	nucleoporin 62	Homo sapiens	0-3
35364736-4	2022	Hypoxia, or a lack of oxygen, is thought to cause enhanced synovial angiogenesis in RA, which is mediated by some of the hypoxia-inducible factors like vascular endothelial growth factor (VEGF).	Oxygen	22-28	vascular endothelial growth factor A	Mus musculus	188-192
35447485-6	2022	Metabolically, activated CD4+ T cells from young calves show significantly greater utilization of mitochondrial respiration, measured by oxygen consumption rate (OCR), and greater glycolytic reserve, measured by extracellular acidification rate (ECAR).	Oxygen	137-143	CD4 molecule	Bos taurus	25-28
33932953-3	2021	LRRC8C knockdown inhibited TNFalpha-induced O2  - production, receptor endocytosis, NF-kappaB activation, and proliferation while LRRC8D knockdown enhanced NF-kappaB activation.	Oxygen	44-49	leucine rich repeat containing 8 VRAC subunit C	Homo sapiens	0-6
33721832-9	2021	Knockdown and overexpression of CNPY2 inhibited and promoted proliferation glucose consumption, lactate production, oxygen consumption and ATP production in cervical cancer cells, respectively.	Oxygen	116-122	canopy FGF signaling regulator 2	Homo sapiens	32-37
35589941-2	2022	Here, we show that genetic deletion or siRNA-mediated downregulation of IL-33 reduces pathological NV in a murine model of oxygen-induced retinopathy (OIR) with no effect on the normal retinal repair.	Oxygen	123-129	interleukin 33	Mus musculus	72-77
33896701-1	2021	Dissolved oxygen (DO)-stat fed-batch culture, which allows a high cell density culture of microorganisms under constant DO conditions, was applied to anti-CRP single-chain variable fragment (scFv) production using recombinant Escherichia coli.	Oxygen	10-16	catabolite gene activator protein	Escherichia coli	155-158
35588210-11	2022	Both treatments upregulated cardiac angiotensin-converting enzyme 2 in O2-exposed rats at P10 and P28.	Oxygen	71-73	angiotensin I converting enzyme 2	Rattus norvegicus	36-67
35636288-6	2022	Subsequently, oxygen generation originating from the catalase activity of CFOs relieves tumor hypoxia and achieves exceptional TME-customized therapeutic effects.	Oxygen	14-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
35247217-0	2022	Tuning the Spin State of the Iron Center by Bridge-Bonded Fe-O-Ti Ligands for Enhanced Oxygen Reduction.	Oxygen	87-93	spindlin 1	Homo sapiens	11-15
35247217-2	2022	Hereon, we provide an axial Fe-O-Ti ligand regulated spin-state transition strategy to improve the oxygen reduction reaction (ORR) activity of Fe centers.	Oxygen	99-105	spindlin 1	Homo sapiens	53-57
35574675-6	2022	Following this, both inhibitor (MDM2) and activator (p19-ARF) protein levels in response to low oxygen stress were studied.	Oxygen	96-102	MDM2 proto-oncogene	Homo sapiens	32-36
33497900-0	2021	Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed encephalopathy after acute carbon monoxide poisoning with up-regulation of brain-derived neurotrophic factor.	Oxygen	11-17	brain derived neurotrophic factor	Homo sapiens	155-188
35437988-2	2022	Here, using first-principles calculations we identify that the two-dimensional ferromagnetic metal organic framework of Mn2C18H12 can serve as a highly efficient single-atom catalyst for spin-triplet O2 activation and CO oxidation.	Oxygen	200-202	spindlin 1	Homo sapiens	187-191
33389617-9	2021	The TRPM2 current density and Ca2+ fluorescence intensity with an increase of mitochondrial membrane depolarization and oxygen free radical (OFR) generations were increased in the ARPE-19 cells by the treatment of HYPX.	Oxygen	120-126	transient receptor potential cation channel subfamily M member 2	Homo sapiens	4-9
35437988-3	2022	The underlying mechanism is via "concerted charge-spin catalysis", involving a delicate synergetic process of charge transfer, provided by the hosting Mn atom, and spin selection, preserved through active participation of its nearest neighboring Mn atoms for the crucial step of O2 activation.	Oxygen	279-281	spindlin 1	Homo sapiens	50-54
35437988-3	2022	The underlying mechanism is via "concerted charge-spin catalysis", involving a delicate synergetic process of charge transfer, provided by the hosting Mn atom, and spin selection, preserved through active participation of its nearest neighboring Mn atoms for the crucial step of O2 activation.	Oxygen	279-281	spindlin 1	Homo sapiens	164-168
35437988-4	2022	The synergetic mechanism is further found to be broadly applicable in O2 adsorption on magnetic X2C18H12 (X = Mn, Fe, Co, and Ni) with a well-defined linear scaling dependence between the chemical activity and spin excitation energy.	Oxygen	70-72	spindlin 1	Homo sapiens	210-214
33545084-0	2021	High oxygen flow rates with the UCL Ventura CPAP device.	Oxygen	5-11	centromere protein J	Homo sapiens	44-48
35451444-5	2022	Compared with cubic SCF-C, the hexagonal SCF-H perovskite oxide has abundant surface oxygen species (O22-/O-), a faster charge transfer rate, and a higher electrochemical surface area.	Oxygen	85-91	KIT ligand	Homo sapiens	41-44
35536460-0	2022	Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner.	Oxygen	76-82	fibroblast growth factor 9	Homo sapiens	58-62
33545085-0	2021	High oxygen flow rates with the UCL Ventura CPAP device - Authors" reply.	Oxygen	5-11	centromere protein J	Homo sapiens	44-48
33427354-6	2021	We successfully used NAD+ from the nanoreactors for the the continuous production of NAD+ to 1) sense glucose in an artificial glucose metabolism, and 2) to reduce the non-oxygen binding methemoglobin to oxygen-binding hemoglobin.	Oxygen	172-178	hemoglobin subunit gamma 2	Homo sapiens	187-200
35543404-1	2022	OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited.	Oxygen	31-37	carbonic anhydrase 5A	Homo sapiens	26-30
35543404-1	2022	OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited.	Oxygen	54-56	carbonic anhydrase 5A	Homo sapiens	26-30
35543404-1	2022	OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited.	Oxygen	195-201	carbonic anhydrase 5A	Homo sapiens	26-30
35543404-1	2022	OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited.	Oxygen	195-201	carbonic anhydrase 5A	Homo sapiens	185-189
33427354-6	2021	We successfully used NAD+ from the nanoreactors for the the continuous production of NAD+ to 1) sense glucose in an artificial glucose metabolism, and 2) to reduce the non-oxygen binding methemoglobin to oxygen-binding hemoglobin.	Oxygen	204-210	hemoglobin subunit gamma 2	Homo sapiens	187-200
35383789-5	2022	When TPZ@FeMSN-GOX entered the tumor cells, GOX could not only exhaust glucose to starve cancer cells and concomitantly produce H2O2, but also consume O2 to aggravate the hypoxia environment and amplify TPZ-mediated chemotherapy.	Oxygen	151-153	hydroxyacid oxidase 1	Homo sapiens	15-18
33791717-5	2021	Large infiltrates by Arginase 1 + G-MDSC (Arg + G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen species) were found in the lungs of patients who died from COVID-19 complications.	Oxygen	122-128	cytochrome b-245 beta chain	Homo sapiens	78-83
35383789-5	2022	When TPZ@FeMSN-GOX entered the tumor cells, GOX could not only exhaust glucose to starve cancer cells and concomitantly produce H2O2, but also consume O2 to aggravate the hypoxia environment and amplify TPZ-mediated chemotherapy.	Oxygen	151-153	hydroxyacid oxidase 1	Homo sapiens	44-47
35500221-3	2022	We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase.	Oxygen	33-39	2,4-dienoyl-CoA reductase 1	Homo sapiens	152-157
35500221-3	2022	We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase.	Oxygen	101-107	2,4-dienoyl-CoA reductase 1	Homo sapiens	152-157
33720684-5	2021	Then, the conjugated GOx can utilize O2 production to catalyze intracellular glucose to generate H2O2, which not only starves the tumor cells but also promotes oxidation of l-Arg to NO.	Oxygen	37-39	hydroxyacid oxidase 1	Homo sapiens	21-24
35307349-7	2022	Finally, using oxygen-glucose deprivation (OGD) as an in vitro model for ischemia, we show that BDNF-TrkB signaling negatively impairs clustering of the main scaffolding protein at GABAergic postsynapse, gephyrin, whereby reducing GABAergic neurotransmission post-ischemia.	Oxygen	15-21	brain derived neurotrophic factor	Homo sapiens	96-100
33757970-5	2021	The lipid CoQ and mitochondrial complex IV, whose biogenesis are lipid-dependent, were found decreased after chemerin inhibition, contributing to lipid reactive oxygen species production.	Oxygen	161-167	retinoic acid receptor responder 2	Homo sapiens	109-117
35521220-12	2022	Interestingly, B. bigemina cultured at 3% oxygen expresses significantly higher levels of LDH and is more resistant to gossypol than the parasites maintained at ambient conditions containing ~20% oxygen.	Oxygen	42-48	LDH	Bos taurus	90-93
33550096-2	2021	Oxygen-dependent hydroxylation of HIF-1alpha is tightly regulated by prolyl hydroxylase domain containing proteins (PHD1, PHD2, and PHD3).	Oxygen	0-6	egl-9 family hypoxia inducible factor 3	Homo sapiens	132-136
35592205-1	2022	Methemoglobin (MetHb) is a form of hemoglobin in which iron in Hb is in an oxidized form (ferric) instead of ferrous, making it difficult to bind with oxygen.	Oxygen	151-157	hemoglobin subunit gamma 2	Homo sapiens	0-13
35167880-0	2022	Hyperbaric oxygen therapy mitigates left ventricular remodeling, upregulates MMP-2 and VEGF, and inhibits the induction of MMP-9, TGF-beta1, and TNF-alpha in streptozotocin-induced diabetic rat heart.	Oxygen	11-17	matrix metallopeptidase 9	Rattus norvegicus	123-128
35495677-1	2022	Uricase catalyzes the conversion of uric acid into allantoin with concomitant reduction of molecular oxygen to hydrogen peroxide.	Oxygen	101-107	urate oxidase (pseudogene)	Homo sapiens	0-7
35417709-0	2022	An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity.	Oxygen	3-9	small nucleolar RNA host gene 12	Homo sapiens	39-45
35417709-3	2022	The interaction between SNHG12 and occludin is oxygen adaptive and could block Itch (an E3 ubiquitin ligase)-mediated ubiquitination and degradation of occludin in human BMECs.	Oxygen	47-53	small nucleolar RNA host gene 12	Homo sapiens	24-30
33512467-5	2021	Consistent with the BM hypoxia induced by G-CSF, low oxygen concentration induced FGF23 release from human erythroblast HUDEP-2 cells in vitro.	Oxygen	53-59	fibroblast growth factor 23	Homo sapiens	82-87
35385843-12	2022	Oxygen free radicals are capable of causing DNA damage via stimulation of the mitogen activating protein (MAP) kinase or phosphatidylinositol-3-kinase (PI3K/Akt) and/or nuclear factor kB (NFkB) pathways resulting in TC-associated-gene mutations such as RET/PTC, AKAP9-BRAF, NTRK1, RAASF, PIK3CA, and PTEN.	Oxygen	0-6	A-kinase anchoring protein 9	Homo sapiens	262-267
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Oxygen	169-175	fission, mitochondrial 1	Homo sapiens	388-392
33656325-3	2021	CuCo(O) was characterized as the Cu0.3Co2.7O4 phase through X-ray diffraction analysis and it can react with H2O2 to generate O2 and alleviate tumor hypoxia, resulting in the recovered enzymatic activity of GOx and the enhanced starvation therapy.	Oxygen	111-113	hydroxyacid oxidase 1	Homo sapiens	207-210
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Oxygen	169-175	mitofusin 2	Homo sapiens	461-465
35406578-7	2022	We showed that under a low-oxygen culture condition and nutrient deprivation, the CD44+/CD24- population is enriched.	Oxygen	27-33	CD44 molecule (Indian blood group)	Homo sapiens	82-86
33656325-5	2021	The three-in-one functions of oxygen supply, glucose consumption, and photothermal conversion were realized in the ZIFs-derived CuCo(O)/GOx@PCNs nanozyme and the starvation therapy effect was improved by PTT and oxygen supplement.	Oxygen	30-36	hydroxyacid oxidase 1	Homo sapiens	136-139
33656325-5	2021	The three-in-one functions of oxygen supply, glucose consumption, and photothermal conversion were realized in the ZIFs-derived CuCo(O)/GOx@PCNs nanozyme and the starvation therapy effect was improved by PTT and oxygen supplement.	Oxygen	212-218	hydroxyacid oxidase 1	Homo sapiens	136-139
33666413-2	2021	The Co-MOF/NF exhibited enhanced catalytic performance for both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER).	Oxygen	110-116	neurofascin	Homo sapiens	11-13
35407938-1	2022	In this paper, low-pressure 95%Ar-5%H2, pure Ar, and 95%Ar-5%O2 plasmas were used for post-treatment of ruthenium (Ru) deposited on nickel foam (NF) (Ru/NF).	Oxygen	61-63	neurofascin	Homo sapiens	132-148
35407938-3	2022	Significant improvement in electrocatalytic activity with the lowest overpotential and Tafel slope was observed in an alkaline electrolyte (1 M KOH) with 95%Ar-5%O2 plasma processing on Ru/NF.	Oxygen	162-164	neurofascin	Homo sapiens	189-191
33790927-0	2021	An Arabidopsis Prolyl 4 Hydroxylase Is Involved in the Low Oxygen Response.	Oxygen	59-65	P4H 	Arabidopsis thaliana	15-35
35237783-5	2022	shRNA-mediated inhibition of ASCT2 function in vitro can significantly decrease glutamine consumption, alpha-ketoglutarate (alpha-KG) production and ATP generation and increase the reactive oxygen species (ROS) level.	Oxygen	190-196	solute carrier family 1 member 5	Homo sapiens	29-34
33705641-0	2021	Hyperbaric oxygen therapy affects insulin sensitivity/resistance by increasing adiponectin, resistin, and plasminogen activator inhibitor-I in rats.	Oxygen	11-17	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	79-90
35367744-4	2022	This work focused on the investigation of Plin5 in oxygen-glucose deprivation/reoxygenation (OGD/R)-injured neurons, an in vitro model for studying cerebral ischemic stroke.	Oxygen	51-57	perilipin 5	Mus musculus	42-47
33507880-6	2021	Suppressing Fasn or Scd1 reduced HL-1 cell proliferation and increased cell death while overexpressing these genes maintained their expansion in hyperoxia, suggesting oxygen directly inhibits atrial cardiomyocyte proliferation and survival by repressing Fasn and Scd1.	Oxygen	167-173	fatty acid synthase	Homo sapiens	12-16
35557761-6	2022	Subsequent direct electron transfer after photo-irradiation induces hPAG +-O2  - formation, and the following spin-flip process generates 1O2.	Oxygen	75-77	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	68-72
35338149-0	2022	GO-SHIP Easy Ocean: Gridded ship-based hydrographic section of temperature, salinity, and dissolved oxygen.	Oxygen	100-106	inositol polyphosphate-5-phosphatase D	Homo sapiens	28-32
33507880-6	2021	Suppressing Fasn or Scd1 reduced HL-1 cell proliferation and increased cell death while overexpressing these genes maintained their expansion in hyperoxia, suggesting oxygen directly inhibits atrial cardiomyocyte proliferation and survival by repressing Fasn and Scd1.	Oxygen	167-173	fatty acid synthase	Homo sapiens	254-258
33507880-6	2021	Suppressing Fasn or Scd1 reduced HL-1 cell proliferation and increased cell death while overexpressing these genes maintained their expansion in hyperoxia, suggesting oxygen directly inhibits atrial cardiomyocyte proliferation and survival by repressing Fasn and Scd1.	Oxygen	167-173	stearoyl-CoA desaturase	Homo sapiens	263-267
33507880-7	2021	Pharmacologic interventions that restore Fasn, Scd1 and other fatty acid synthesis genes in atrial cardiomyocytes may thus provide a way of ameliorating the adverse effects of supplemental oxygen on preterm infants.	Oxygen	189-195	fatty acid synthase	Homo sapiens	41-45
35288580-5	2022	beta-cell-specific Tfeb knockout (TfebDeltabeta-cell) abrogated high-fat diet (HFD)-induced mitophagy, accompanied by increased ROS and reduced mitochondrial cytochrome c oxidase activity or O2 consumption.	Oxygen	191-193	transcription factor EB	Mus musculus	19-23
33507880-7	2021	Pharmacologic interventions that restore Fasn, Scd1 and other fatty acid synthesis genes in atrial cardiomyocytes may thus provide a way of ameliorating the adverse effects of supplemental oxygen on preterm infants.	Oxygen	189-195	stearoyl-CoA desaturase	Homo sapiens	47-51
35239685-8	2022	Mitochondria uncoupling mediated by uncoupling protein 2 and the adenosine nucleotide transporter was demonstrated as a mechanism causing the increased kidney oxygen consumption.	Oxygen	159-165	uncoupling protein 2	Rattus norvegicus	36-56
33507881-7	2021	Mechanistically, KLF11 not only inhibited the EC inflammatory response but also diminished MMP9 expression and activity and reduced NADPH oxidase 2-mediated production of reactive oxygen species in ECs.	Oxygen	180-186	cytochrome b-245 beta chain	Homo sapiens	132-147
35300418-8	2022	Exposure to low oxygen levels increased the protein expression of the glial fibrillary acid protein (GFAP) in MGCs, whereas Vimentin levels remained constant.	Oxygen	16-22	glial fibrillary acidic protein	Homo sapiens	70-99
33754030-7	2021	SIRT2 deficiency or inhibition by AGK2 decreased GSIS in isolated rat islets, with lowered oxygen consumption rate.	Oxygen	91-97	sirtuin 2	Rattus norvegicus	0-5
35300418-8	2022	Exposure to low oxygen levels increased the protein expression of the glial fibrillary acid protein (GFAP) in MGCs, whereas Vimentin levels remained constant.	Oxygen	16-22	glial fibrillary acidic protein	Homo sapiens	101-105
33404366-10	2021	Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1.	Oxygen	11-13	ORAI calcium release-activated calcium modulator 1	Homo sapiens	120-125
35104504-10	2022	We show that these interactions are functionally significant, as loss of function of IGF2BP1 leads to destabilization of GPX mRNAs and reduces mitochondrial membrane potential and oxygen consumption.	Oxygen	180-186	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	85-92
35220394-3	2022	Transmission electron microscopy, proximity ligation assays for mitochondrial VDAC1 and endoplasmic reticulum IP3R, and immunoanalyses of p-DRP1 and OPA1, demonstrate that low-oxygen conditions in early 1st trimester and PE promote mitochondrial fission in pMSCs.	Oxygen	176-182	utrophin	Homo sapiens	140-144
33732160-3	2021	The PROK2 expression levels can be increased by a series of pathological insults, such as hypoxia, reactive oxygen species, beta amyloid and excitotoxic glutamate.	Oxygen	108-114	prokineticin 2	Homo sapiens	4-9
35220394-5	2022	Inhibition of DRP1 oligomerization with MDiVi-1 shows that low oxygen-induced mitochondrial fission is a direct consequence of DRP1 activation, likely via HIF1.	Oxygen	63-69	utrophin	Homo sapiens	14-18
35119268-6	2022	However, in the absence of ATZ, H2O2 and O2 - are key intermediates and precursors for 1O2, whereas in the presence of ATZ, a different pathway was followed to produce O2 - and 1O2.	Oxygen	41-45	immunoglobulin kappa variable 1D-39	Homo sapiens	168-180
33444122-0	2021	Soluble ICAM-1 is Modulated by Hyperbaric Oxygen Treatment and Correlates with Disease Severity and Mortality in Patients with Necrotizing Soft-tissue Infection.	Oxygen	42-48	intercellular adhesion molecule 1	Homo sapiens	8-14
35153295-6	2022	Knock-down of circPUM1 would result in lower intracellular oxygen concentration, downregulated oxidative phosphorylation, decrease of mitochondrial membrane potential, increase of ROS generation and shrinking of mitochondria, respectively.	Oxygen	59-65	pumilio RNA binding family member 1	Homo sapiens	14-22
33482529-1	2021	Spin-lock preparation was studied to detect tiny oscillatory magnetic fields such as a neural magnetic field without the blood oxygen level-dependent effect.	Oxygen	127-133	spindlin 1	Homo sapiens	0-4
35216064-3	2022	We demonstrated that oxygen/glucose deprivation (OGD)-induced cell proliferation of NS/PC was increased by rPGRN treatment.	Oxygen	21-27	granulin precursor	Rattus norvegicus	107-112
33279623-5	2021	CD45+CD71+ erythroid cells suppressed T cells through generation of reactive oxygen species, IL-10, and TGF-beta in a paracrine and cell-cell contact manner, and their suppressive effect was stronger than that of myeloid-derived suppressor cells.	Oxygen	77-83	protein tyrosine phosphatase receptor type C	Homo sapiens	0-4
35060702-2	2022	Recently, the reported crystal structure of NicX has lent support to an apical dioxygen catalytic mechanism, while the mechanistic details remain unclear.	Oxygen	79-87	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	44-48
35060702-3	2022	In this work, we constructed a Fe(II)-O2-substrate complex model and performed a series of combined quantum mechanics/molecular mechanics (QM/MM) calculations to illuminate the catalysis of NicX.	Oxygen	38-40	2,5-dihydroxypyridine 5,6-dioxygenase	Pseudomonas putida KT2440	190-194
33492339-3	2021	KDM4A, a demethylase that belongs to the Fe-II dependent dioxygenase family that uses alpha-ketoglutarate and molecular oxygen as cofactors, is overexpressed in several cancers and is associated with an overall poor prognosis.	Oxygen	59-65	lysine demethylase 4A	Homo sapiens	0-5
35163700-0	2022	The SDF1-CXCR4 Axis Is Involved in the Hyperbaric Oxygen Therapy-Mediated Neuronal Cells Migration in Transient Brain Ischemic Rats.	Oxygen	50-56	C-X-C motif chemokine receptor 4	Rattus norvegicus	9-14
33599699-6	2021	Here, we summarise the recent advances made to our understanding of the role of CHCHD4 and the DRS in physiology and disease, with a specific focus on the emerging importance of CHCHD4 in regulating the cellular response to low oxygen (hypoxia) and metabolism in cancer.	Oxygen	228-234	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	178-184
35160240-2	2022	A pathological shift in the oxyhemoglobin curve (ODC) was previously described through the analysis of p50, intended as the oxygen tension at which hemoglobin is saturated by oxygen at 50%.	Oxygen	124-130	activating signal cointegrator 1 complex subunit 1	Homo sapiens	103-106
35160240-2	2022	A pathological shift in the oxyhemoglobin curve (ODC) was previously described through the analysis of p50, intended as the oxygen tension at which hemoglobin is saturated by oxygen at 50%.	Oxygen	175-181	activating signal cointegrator 1 complex subunit 1	Homo sapiens	103-106
33633112-5	2021	PIWIL1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic glycolysis.	Oxygen	17-23	piwi like RNA-mediated gene silencing 1	Homo sapiens	0-6
35160240-3	2022	The aim of this study was to analyze Hb-O2 affinity features over time in a cohort of critically ill COVID-19 patients, through the analysis of ODC p50 behavior.	Oxygen	40-42	activating signal cointegrator 1 complex subunit 1	Homo sapiens	148-151
33615851-7	2022	The NIR-based device used in this study estimates effective changes in TO in terms of oxy-, deoxy-, total hemoglobin, and oxygen saturation.	Oxygen	122-128	tryptophan 2,3-dioxygenase	Homo sapiens	71-73
35265197-7	2022	FCP-Tph/HA possesses an enhanced antitumor effect in vitro through the specific binding of HA to CD44 and combining chemotherapy with oxygen self-supplying PDT.	Oxygen	134-140	FCP1	Homo sapiens	0-3
35603281-5	2022	Here, we leveraged a set of features using GFT that quantified the coupling between blood oxygen level dependent signals and structural connectome to investigate their associations with serum NfL levels collected from healthy subjects and former athletes with history of concussions.	Oxygen	90-96	neurofilament light chain	Homo sapiens	192-195
33482580-1	2021	Tuberous sclerosis complex 2 (TSC2) is a tumor-suppressor protein that is partially regulated by insulin, energy, oxygen, and growth factors.	Oxygen	114-120	TSC complex subunit 2	Homo sapiens	0-28
34981938-2	2022	These are prepared by cryoreduction/annealing of the parent (LCuI(O2))+ Cu(I) dioxygen adducts with the tripodal, N4-coordinating, tetradentate ligands L = PVtmpa, DMMtmpa, TMG3tren and are best described as (LCuII(O2 -))+ Cu(II) complexes that possess end-on (eta1-O2 -) superoxo coordination.	Oxygen	214-220	proline rich and Gla domain 3	Homo sapiens	173-177
35096774-4	2021	Benefiting from its abundant active sites, high surface area and effective ionic conduction capability from three-dimensional (3D) nanofiber framework, Pd-Co3O4@CNF works as bifunctional oxygen electrode and exhibits superior activity and stability superior to commercial catalysts.	Oxygen	187-193	NPHS1 adhesion molecule, nephrin	Homo sapiens	161-164
34969852-0	2022	Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome.	Oxygen	16-22	2,4-dienoyl-CoA reductase 1	Homo sapiens	54-59
34969852-2	2022	Using Saccharomyces cerevisiae and mammalian cells, we discovered that a major aspect of the antioxidant function of Sod1 is to integrate O2 availability to promote NADPH production.	Oxygen	138-140	2,4-dienoyl-CoA reductase 1	Homo sapiens	165-170
33482580-1	2021	Tuberous sclerosis complex 2 (TSC2) is a tumor-suppressor protein that is partially regulated by insulin, energy, oxygen, and growth factors.	Oxygen	114-120	TSC complex subunit 2	Homo sapiens	30-34
33145913-2	2021	For HBpin (= 4,4,5,5-tetramethyl-1,3,2-dioxaborolane) and HBdan (= 1,8-naphthalenediaminatoborane), the B-H bonds were cleaved into a B anion on the metal and an H cation on the phenolic oxygen in the ligand.	Oxygen	187-193	bleomycin hydrolase	Homo sapiens	104-107
33860083-1	2021	Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electrons to oxygen to generate hydrogen peroxide (H2O2).	Oxygen	155-161	cytochrome b5 reductase 1	Homo sapiens	123-129
33548224-4	2021	Hepatocytes isolated from liver-specific LRP1 knockout (hLrp1-/-) mice showed reduced oxygen consumption compared to control mouse hepatocytes.	Oxygen	86-92	low density lipoprotein receptor-related protein 1	Mus musculus	41-45
33090629-0	2021	How Oxygen-binding Enhances Long-range Electron Transfer: Lessons from Reduction of Lytic Polysaccharide Monooxygenases by Cellobiose Dehydrogenase.	Oxygen	4-10	choline dehydrogenase	Homo sapiens	123-147
33503557-5	2021	In invitro models of senescent foamy macrophages and senescent endothelial cells stimulated with oxidized high-density-lipoprotein, the CD9 antibody-modified mesoporous silica nanoparticles exhibit high cellular uptake; reduce the reactive oxygen species level, high-density lipoprotein oxidation, and production of TNF-alpha and IL-6; and attenuate the senescence process, contributing to improved cell viability.	Oxygen	240-246	CD9 antigen	Mus musculus	136-139
33129969-7	2021	Furthermore, deficiency of BCO2 resulted in inactivation of mitochondrial MnSOD enzyme, excessive production of reactive oxygen species, and elevation of protein levels of stimulator of interferon genes (STING) and interferon regulatory factor 3 (IRF3) in the hypothalamus.	Oxygen	121-127	beta-carotene oxygenase 2	Mus musculus	27-31
33573145-0	2021	Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury.	Oxygen	11-17	heme oxygenase 1	Rattus norvegicus	46-62
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	Oxygen	111-117	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	46-50
33469230-9	2021	Loss of Tead1 expression in adult CMs increased mitochondrial reactive oxygen species, disrupted the structure of mitochondria, reduced complex I-IV driven oxygen consumption and ATP levels, resulting in the activation of necroptosis.	Oxygen	71-77	TEA domain family member 1	Mus musculus	8-13
33469230-9	2021	Loss of Tead1 expression in adult CMs increased mitochondrial reactive oxygen species, disrupted the structure of mitochondria, reduced complex I-IV driven oxygen consumption and ATP levels, resulting in the activation of necroptosis.	Oxygen	156-162	TEA domain family member 1	Mus musculus	8-13
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	angiotensin I converting enzyme 2	Rattus norvegicus	171-202
33488404-11	2020	Oxygen enrichment inhibited HAH-induced excessive expression of cytokines associated with cardiac hypertrophy and myocardial fibrosis [angiotensin-converting enzyme (ACE)/angiotensin-converting enzyme 2 (ACE2), angiotensin II (Ang II), collagen type I alpha 1 (Col1alpha1), collagen type III alpha 1 (Col3alpha1), and hydroxyproline] in the right ventricle (RV).	Oxygen	0-6	angiotensin I converting enzyme 2	Rattus norvegicus	204-208
33242700-7	2021	A QSAR model for tyrosinase inhibitory activity was built using six molecular descriptors, with a partial negative surface area descriptor and the relative number of oxygen atoms being positively contributing to the tyrosinase inhibitory activity.	Oxygen	166-172	tyrosinase	Homo sapiens	17-27
33242700-7	2021	A QSAR model for tyrosinase inhibitory activity was built using six molecular descriptors, with a partial negative surface area descriptor and the relative number of oxygen atoms being positively contributing to the tyrosinase inhibitory activity.	Oxygen	166-172	tyrosinase	Homo sapiens	216-226
32515547-8	2021	SGLT2i also increased oxygen consumption under controlled-feeding.	Oxygen	22-28	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	0-5
33087445-3	2020	Here we show that Akt3 depletion in primary endothelial cells (EC) results in decreased uncoupled oxygen consumption, increased fission, decreased membrane potential and increased expression of the mitochondria-specific protein chaperones, HSP60 and HSP10, suggesting that Akt3 is required for mitochondrial homeostasis.	Oxygen	98-104	AKT serine/threonine kinase 3	Homo sapiens	18-22
33291125-2	2020	In this work, we have prepared new Al-doped Ni3S2 nanosheet arrays grown on Ni foam (Al-Ni3S2/NF) as an excellent bifunctional electrocatalyst in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER).	Oxygen	188-194	neurofascin	Homo sapiens	94-96
34027350-7	2021	Circulating TRACP5b levels were correlated with peak breath-by-breath oxygen consumption, but not with left ventricular ejection fraction.	Oxygen	70-76	acid phosphatase 5, tartrate resistant	Homo sapiens	12-19
33180482-1	2020	We describe here nitric oxide dioxygenation (NOD) by the dioxygen manganese porphyrin adducts Mn(Por)(eta2-O2) (Por2- = the meso-tetra-phenyl or meso-tetra-p-tolylporphyrinato dianions, TPP2- and TTP2-).	Oxygen	30-38	tripeptidyl peptidase 2	Homo sapiens	186-190
33259229-6	2021	Glucose fluctuation induced oxidative stress in H9c2 cells, while these changes were reversed effectively by SGLT1 knockdown, as manifested by reduction of intracellular reactive oxygen species and increased antioxidase activity.	Oxygen	179-185	solute carrier family 5 member 1	Rattus norvegicus	109-114
33125150-2	2020	Glutathione produced by the G6PD pathway can reduce the degree of harm caused by reactive oxygen species such as oxygen-containing free radicals, peroxides and lipid peroxides.	Oxygen	90-96	glucose-6-phosphate dehydrogenase	Homo sapiens	28-32
33147303-0	2020	Design of Fe,N co-doped multi-walled carbon nanotubes for efficient oxygen reduction.	Oxygen	68-74	general transcription factor IIE subunit 1	Homo sapiens	10-12
33147303-1	2020	Unique Fe and N co-doped multi-walled carbon nanotubes are designed to efficiently catalyze the oxygen reduction reaction (ORR).	Oxygen	96-102	general transcription factor IIE subunit 1	Homo sapiens	7-9
35392250-9	2022	Metabolite studies by NMR and flux analyses by LC-MS support a mechanism, wherein DeltaPsi effects on the production of reactive oxygen alters the NADH/NAD+ ratio affecting OAA accumulation and, hence, OAA inhibition of SDH.	Oxygen	129-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	220-223
35158330-2	2021	NF-kappaB is activated by superoxide (O2  -)- producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase homologues, including NADPH oxidase 2 (Nox2), and vice versa, with NF-kappaB inducing Nox2.	Oxygen	38-43	cytochrome b-245 beta chain	Rattus norvegicus	138-153
35158330-2	2021	NF-kappaB is activated by superoxide (O2  -)- producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase homologues, including NADPH oxidase 2 (Nox2), and vice versa, with NF-kappaB inducing Nox2.	Oxygen	38-43	cytochrome b-245 beta chain	Rattus norvegicus	155-159
35158330-2	2021	NF-kappaB is activated by superoxide (O2  -)- producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase homologues, including NADPH oxidase 2 (Nox2), and vice versa, with NF-kappaB inducing Nox2.	Oxygen	38-43	cytochrome b-245 beta chain	Rattus norvegicus	202-206
33173134-4	2020	The 13 outlier windows detected by at least two approaches, harboured genes (e.g. GH1, ACE, ASIC3, HSPH1, MVD, BCL2, HIGD2A, CBFA2T3) that may be involved in physiological adaptations required to cope with environmental stressors that are typical of the North African area such as infectious diseases, extended drought periods, scarce food supply, oxygen scarcity in the mountainous areas and high-intensity solar radiation.	Oxygen	348-354	acid sensing ion channel subunit 3	Bos taurus	92-97
33167645-2	2020	Gas phase metal ions and their oxides (VO2 +, NbO2 +, and TaO2 +) are formed and spectroscopically characterized using IR multiple-photon dissociation spectroscopy via loss of atomic oxygen and overcoming fragmentation energies of 3 eV-6 eV.	Oxygen	183-189	TAO kinase 2	Homo sapiens	58-62
32717518-5	2020	Moreover, the ratio of chemical oxygen demand to total nitrogen (C/N) was identified as an effective regulator for the distribution of C14-HSL and 3-oxo-C14-HSL.	Oxygen	32-38	lipase E, hormone sensitive type	Homo sapiens	139-142
32806277-4	2020	The nano-conjugate constitutes of the nano-carrier (AuNP-PEG-RGD) and glucose oxidase (GOx, activity equivalent), which not only can specifically target cancer cells with the help of the cancer-targeting peptide (RGD) laid on the surface, but also can deplete glucose and O2 with the simultaneous generation of H2O2.	Oxygen	272-274	hydroxyacid oxidase 1	Homo sapiens	70-85
32806277-4	2020	The nano-conjugate constitutes of the nano-carrier (AuNP-PEG-RGD) and glucose oxidase (GOx, activity equivalent), which not only can specifically target cancer cells with the help of the cancer-targeting peptide (RGD) laid on the surface, but also can deplete glucose and O2 with the simultaneous generation of H2O2.	Oxygen	272-274	hydroxyacid oxidase 1	Homo sapiens	87-90
32980493-7	2020	With recent update of the signaling pathway revealing link connecting TSPO with neuroinflammatory effectors such as reactive oxygen species, we discuss TSPO as a therapeutic targeting tool for suppression of adverse effect of stressors on long-lasting changes in animal behaviors and activities.	Oxygen	125-131	translocator protein	Homo sapiens	152-156
32573860-6	2020	In vitro, astrocytes exposed to hypoxia (4% O2 ) for 24 hr exhibited and increase in IL-1beta expression followed by an increase in vascular endothelial growth factor (VEGF) levels.	Oxygen	44-46	vascular endothelial growth factor A	Mus musculus	132-166
32573860-6	2020	In vitro, astrocytes exposed to hypoxia (4% O2 ) for 24 hr exhibited and increase in IL-1beta expression followed by an increase in vascular endothelial growth factor (VEGF) levels.	Oxygen	44-46	vascular endothelial growth factor A	Mus musculus	168-172
32656734-0	2020	Reduced nNOS activity is responsible for impaired fatty acid-dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat.	Oxygen	85-91	nitric oxide synthase 1	Rattus norvegicus	8-12
33142842-6	2020	In addition, measurements of the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) indicated that PURalpha promoted the metabolism of ESCC cells.	Oxygen	33-39	purine rich element binding protein A	Homo sapiens	122-130
33149811-8	2020	Mfn2 silencing attenuated mitochondrial oxidative stress and Ca2+ overload, increased mitochondrial membrane potential and mitochondrial oxygen consumption, and protected cells from TM-induced apoptosis.	Oxygen	137-143	mitofusin 2	Homo sapiens	0-4
33192549-11	2020	Moreover, USP22, SIRT1, or SLC7A11 elevation contributed to enhanced cardiomyocyte viability and attenuated ferroptosis-induced cell death in vitro, accompanied by increased GSH levels, as well as decreased reactive oxygen species production, lipid peroxidation, and iron accumulation.	Oxygen	216-222	ubiquitin specific peptidase 22	Rattus norvegicus	10-15
32697241-2	2020	The generation of oxygen through electrolysis is discussed as an example in which chirality-based spin-filtering and spin selection rules can be used to improve the reaction"s efficiency and selectivity.	Oxygen	18-24	spindlin 1	Homo sapiens	98-102
32697241-2	2020	The generation of oxygen through electrolysis is discussed as an example in which chirality-based spin-filtering and spin selection rules can be used to improve the reaction"s efficiency and selectivity.	Oxygen	18-24	spindlin 1	Homo sapiens	117-121
33021853-5	2020	In addition, PA altered intracellular redox status and induced reactive oxygen species that were reduced by C3G via the redox-sensitive Nrf2 signalling.	Oxygen	72-78	Rap guanine nucleotide exchange factor 1	Homo sapiens	108-111
33024205-5	2020	The high sensitivity towards dissolved oxygen of 648 +- 51 microA mM-1 cm-2, and a LOD of 1.7 microM, was achieved for the PGE with surface previously modified with reduced graphene (rGO), almost the double registered for direct anchorage on the bare PGE surface.	Oxygen	39-45	Mix1 homeobox-like 1 (Xenopus laevis)	Mus musculus	66-75
32941030-8	2020	The thermal luminescence spectra show that after the incorporation of Ga3+ the oxygen vacancy and intrinsic defects in LBO remain unchanged but that the concentration of oxygen vacancy significantly reduces.	Oxygen	79-85	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	70-73
32941030-8	2020	The thermal luminescence spectra show that after the incorporation of Ga3+ the oxygen vacancy and intrinsic defects in LBO remain unchanged but that the concentration of oxygen vacancy significantly reduces.	Oxygen	170-176	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	70-73
33082910-0	2020	Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.	Oxygen	91-97	tubulin polymerization promoting protein family member 3	Homo sapiens	15-20
32776367-0	2020	Spin-Related Electron Transfer and Orbital Interactions in Oxygen Electrocatalysis.	Oxygen	59-65	spindlin 1	Homo sapiens	0-4
32776367-4	2020	Because the oxygen molecule is paramagnetic, its production from or its reduction to diamagnetic hydroxide/water involves spin-related electron transfer.	Oxygen	12-18	spindlin 1	Homo sapiens	122-126
32776367-9	2020	Spin electrocatalysis may emerge as an important topic in the near future and help integrate a comprehensive understanding of oxygen electrocatalysis.	Oxygen	126-132	spindlin 1	Homo sapiens	0-4
33019722-7	2020	OSCC cells expressing high levels of ROS1 consumed more oxygen and had increased levels of cellular ATP levels.	Oxygen	56-62	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	37-41
32012263-6	2020	Overexpression of SDHB in HUVECs enhanced pyroptosis and impaired mitochondria and high reactive oxygen species (ROS) level.	Oxygen	97-103	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	18-22
32912499-0	2020	Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose-Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis.	Oxygen	34-40	forkhead box O3	Mus musculus	128-133
32246643-10	2020	Our results indicate that miR-142-3p down-regulates the expression and activation of Rac1, regulates mitochondrial biogenesis and function, and inhibits oxygen-glucose deprivation damage, thus exerting a neuroprotective effect.	Oxygen	153-159	Rac family small GTPase 1	Homo sapiens	85-89
32962633-5	2020	Human umbilical vein endothelial cells (HUVECs) were exposed to hypoxia (1% O2) for 12 h, which significantly induced GLUT1 expression and translocation to the plasma membrane.	Oxygen	76-78	solute carrier family 2 member 1	Homo sapiens	118-123
33036524-0	2020	[The mechanism of hyperbaric oxygen regulating HMGB1 in the prevention and treatment of encephalopathy after acute CO poisoning].	Oxygen	29-35	high mobility group box 1	Rattus norvegicus	47-52
33036524-1	2020	Objective: To study the expression of high mobility group protein 1 (HMGB1) in the brain of rats after hyperbaric oxygen (HBO) treatment of acute carbon monoxide poisoning (DEACMP) , and to explore the mechanism of HBO in the prevention and treatment of DEACMP pathological process by regulating HMGB1.	Oxygen	114-120	high mobility group box 1	Rattus norvegicus	38-67
33036524-1	2020	Objective: To study the expression of high mobility group protein 1 (HMGB1) in the brain of rats after hyperbaric oxygen (HBO) treatment of acute carbon monoxide poisoning (DEACMP) , and to explore the mechanism of HBO in the prevention and treatment of DEACMP pathological process by regulating HMGB1.	Oxygen	114-120	high mobility group box 1	Rattus norvegicus	69-74
32387364-6	2020	The dual modification significantly increased the partial oxygen pressure at 50% saturation (P50) of HbA from 14.8 mmHg to 34.6 mmHg and OTE from 9.1% to 33.1%.	Oxygen	58-64	keratin 90, pseudogene	Homo sapiens	101-104
31954830-5	2020	Similarly, the levels of the NLRP1 inflammasome proteins, cleaved caspase-1, mature IL-1beta and IL-18 were elevated in SY-5Y cells exposed to oxygen-glucose deprivation (OGD).	Oxygen	143-157	interleukin 18	Homo sapiens	97-102
32929130-4	2020	The reducibility character and surface adsorbed oxygen vacancies of the perovskites were further improved, as revealed by H2-TPR, O2-TPD and XPS studies.	Oxygen	48-54	translocated promoter region, nuclear basket protein	Homo sapiens	125-128
32679097-0	2020	O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.	Oxygen	0-2	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	109-114
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Oxygen	17-19	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
32679097-5	2020	Mechanistically, O2 suppresses TRPA1 channel activity by protein internalization via O2-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).	Oxygen	85-87	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
33015012-11	2020	CD8+ T cell infiltration was impaired under pathophysiological oxygen levels and we were also able to establish that hypoxia and PD-L1 inhibition re-sensitized BCa cells to cytotoxic CD8+ T cells.	Oxygen	63-69	CD8a molecule	Homo sapiens	0-3
33015023-2	2020	Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard.	Oxygen	101-107	hydroxyacid oxidase 1	Homo sapiens	0-15
33015023-2	2020	Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard.	Oxygen	101-107	hydroxyacid oxidase 1	Homo sapiens	17-20
33015023-7	2020	When oxygen is plentiful, GOx promotes glucose consumption, allowing amplification of its effects on tumor starvation.	Oxygen	5-11	hydroxyacid oxidase 1	Homo sapiens	26-29
33101005-5	2020	In addition, we confirmed that the recombinant mouse (rm) IL-17A could significantly aggravate 1-h oxygen-glucose deprivation/24-h reoxygenation (1-h OGD/R 24 h)-induced ischemic injuries in cortical neurons in a dose-dependent manner, and the rmIL-17A could also exacerbate neuronal apoptosis through caspase-12 (not caspase-8 or caspase-9)-dependent pathway.	Oxygen	99-105	interleukin 17A	Mus musculus	58-64
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Oxygen	16-22	euchromatic histone lysine methyltransferase 2	Homo sapiens	111-114
33088284-7	2020	In this manner, the methyltransferase activity of G9a and GLP are hypoxia-inducible and thus present a new avenue of low-oxygen signaling.	Oxygen	121-127	euchromatic histone lysine methyltransferase 2	Homo sapiens	50-53
33088284-9	2020	In this article we aim to review the effects of oxygen on G9a and GLP function, non-histone methylation events inflicted by these methyltransferases, and the clinical relevance of these enzymes in cancer.	Oxygen	48-54	euchromatic histone lysine methyltransferase 2	Homo sapiens	58-61
32687357-4	2020	The electron abstraction occurs from either nitrogen or oxygen in the peptide backbone and induces the cleavage of both Calpha-C and N-H bonds in most amino acid residues, except for those on the N-terminal sides of Pro residues.	Oxygen	56-62	carbonic anhydrase 2	Homo sapiens	120-128
33145268-1	2020	Background: Peroxiredoxin 4 (Prdx4), a member of the Prdx family, can catalyze the reduction of reactive oxygen species.	Oxygen	105-111	peroxiredoxin 4	Homo sapiens	12-27
33145268-1	2020	Background: Peroxiredoxin 4 (Prdx4), a member of the Prdx family, can catalyze the reduction of reactive oxygen species.	Oxygen	105-111	peroxiredoxin 4	Homo sapiens	29-34
33145268-1	2020	Background: Peroxiredoxin 4 (Prdx4), a member of the Prdx family, can catalyze the reduction of reactive oxygen species.	Oxygen	105-111	peroxiredoxin 4	Homo sapiens	29-33
33054048-4	2020	The biochemical consequences of PKD result in hemolytic anemia due to red cell pyruvate and ATP deficiency while simultaneously causing increased red cell 2,3-diphosphoglycerate, which facilitates oxygen unloading.	Oxygen	197-203	protein kinase D1	Homo sapiens	32-35
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	Oxygen	304-310	pyruvate dehydrogenase kinase 1	Homo sapiens	142-146
31729644-2	2020	Reactive oxygen species modulator 1 (ROMO1) and the overlapping with the M-AAA protease 1 homolog (OMA1) proteins are the most important mitochondrial membrane proteins, which are involved in modulating reactive oxygen species (ROS) production and the regulation of mitochondrial structure dynamics.	Oxygen	9-15	reactive oxygen species modulator 1	Homo sapiens	37-42
31729644-2	2020	Reactive oxygen species modulator 1 (ROMO1) and the overlapping with the M-AAA protease 1 homolog (OMA1) proteins are the most important mitochondrial membrane proteins, which are involved in modulating reactive oxygen species (ROS) production and the regulation of mitochondrial structure dynamics.	Oxygen	212-218	reactive oxygen species modulator 1	Homo sapiens	37-42
32739205-7	2020	ARG2 knockdown reduced the level of reactive oxygen species and 3-nitrotyrosine after hypoxia-reoxygenation injury compared with control siRNA.	Oxygen	45-51	arginase type II	Mus musculus	0-4
32993999-2	2020	This investigation reports an effective reversion of the above pathological characteristics in RA owing to the use of a prolonged O2/Ca2+-supporting phototherapy hydrogel.	Oxygen	130-132	carbonic anhydrase 2	Homo sapiens	133-136
32993999-4	2020	Furthermore, the Ca2+, which is the other decomposition product of the O2 donor, induces mitochondrial Ca2+ overload and endoplasmic reticulum Ca2+ disorder and triggers Ca2+-associated apoptosis and immunogenic cell death.	Oxygen	71-73	carbonic anhydrase 2	Homo sapiens	17-20
32993999-4	2020	Furthermore, the Ca2+, which is the other decomposition product of the O2 donor, induces mitochondrial Ca2+ overload and endoplasmic reticulum Ca2+ disorder and triggers Ca2+-associated apoptosis and immunogenic cell death.	Oxygen	71-73	carbonic anhydrase 2	Homo sapiens	103-106
32993999-4	2020	Furthermore, the Ca2+, which is the other decomposition product of the O2 donor, induces mitochondrial Ca2+ overload and endoplasmic reticulum Ca2+ disorder and triggers Ca2+-associated apoptosis and immunogenic cell death.	Oxygen	71-73	carbonic anhydrase 2	Homo sapiens	103-106
32993999-4	2020	Furthermore, the Ca2+, which is the other decomposition product of the O2 donor, induces mitochondrial Ca2+ overload and endoplasmic reticulum Ca2+ disorder and triggers Ca2+-associated apoptosis and immunogenic cell death.	Oxygen	71-73	carbonic anhydrase 2	Homo sapiens	103-106
32736709-3	2020	We found that NCX1 was upregulated in the pulmonary arteries of mice exposed to chronic hypoxia (10% O2 for 4 weeks).	Oxygen	101-103	solute carrier family 8 (sodium/calcium exchanger), member 1	Mus musculus	14-18
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Oxygen	9-15	interleukin 18	Homo sapiens	267-281
33405265-0	2020	Corrigendum: Understanding the Role of Solvents and Spin-Orbit Coupling in an Oxygen-Assisted SN2-Type Oxidative Transmetalation Reaction.	Oxygen	78-84	spindlin 1	Homo sapiens	52-56
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	155-161	neutrophil cytosolic factor 1	Homo sapiens	60-67
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	155-161	Rac family small GTPase 1	Homo sapiens	82-87
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	174-180	neutrophil cytosolic factor 1	Homo sapiens	60-67
32442539-7	2020	Phosphorylation of the cytosolic components of NOX, such as p47phox, p67phox, and RAC-1, in hyperglycaemia is one of the important causes of conversion of oxygen to reactive oxygen.	Oxygen	174-180	Rac family small GTPase 1	Homo sapiens	82-87
32776353-1	2021	Tyrosinase starts melanogenesis and determines its course, catalysing the oxidation by molecular oxygen of tyrosine to dopa, and that of dopa to dopaquinone.	Oxygen	97-103	tyrosinase	Homo sapiens	0-10
32848706-3	2020	Alzheimer"s disease may occur when RAGE binds to Abeta and releases reactive oxygen species, further exacerbating Abeta deposition and eventually leading to SPs and NFTs.	Oxygen	77-83	advanced glycosylation end-product specific receptor	Homo sapiens	35-39
32500268-8	2020	Melittin hinders fungal growth by several mechanisms such as membrane permeabilization, apoptosis induction by reactive oxygen species-mediated mitochondria/caspase-dependent pathway, inhibition of (1,3)-beta-D-glucan synthase, and alterations in fungal gene expression.	Oxygen	120-126	melittin	Apis mellifera	0-8
32240450-8	2020	In vitro, RhoA was overexpressed in oxygen-glucose deprivation and reperfusion (OGD/R)-induced PC12 cells to confirm the contribution of RhoA-ROCK signaling inhibition by SC to the neuroprotective effects post OGD/R.	Oxygen	36-42	ras homolog family member A	Rattus norvegicus	10-14
32442882-9	2020	A significant reduction in endothelial cells ICAM-1 (CD54) implicated in inflammatory cell margination across the blood brain barrier was observed under oxygen treatment.	Oxygen	153-159	intercellular adhesion molecule 1	Homo sapiens	45-51
32442882-9	2020	A significant reduction in endothelial cells ICAM-1 (CD54) implicated in inflammatory cell margination across the blood brain barrier was observed under oxygen treatment.	Oxygen	153-159	intercellular adhesion molecule 1	Homo sapiens	53-57
32305330-8	2020	The results indicate no additive effect of high hormone concentrations in genomic damage in the in vitro model, which may be due to exhaustion of the NOX 2-mediated reactive oxygen production.	Oxygen	174-180	cytochrome b-245 beta chain	Homo sapiens	150-155
32737440-7	2020	Raman spectroscopy and X-ray photoelectron spectroscopy revealed the high dispersion of graphene oxide-like carbonaceous moieties in MCS materials; the type and amount of oxygen-containing groups in obtained MCS materials were determined by H2SO4 concentration.	Oxygen	171-177	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	208-211
32609498-1	2020	Enzymatic browning is one of the main problems faced by the food industry due to the enzyme polyphenol oxidase (PPO) action provoking undesirable colour change in the presence of oxygen.	Oxygen	179-185	polyphenol oxidase, chloroplastic	Malus domestica	112-115
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	ASXL transcriptional regulator 1	Homo sapiens	91-96
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	ASXL transcriptional regulator 1	Homo sapiens	140-145
32683582-7	2021	Specific deletion of the mutant allele eliminates the expression of C-terminally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1, thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes, particularly those involved in glucose metabolism, oxygen sensing, and JAK-STAT3 signaling pathways.	Oxygen	278-284	ASXL transcriptional regulator 1	Homo sapiens	140-145
32325093-6	2020	It also provided marked protective action against increased mitochondrial superoxide formation and Bnip3 overexpression, which both markedly induce depolarized mitochondrial potential, increase reactive oxygen species, mitochondrial swelling and fission, and accelerate mitochondrial turnover via autophagy.	Oxygen	203-209	BCL2 interacting protein 3	Rattus norvegicus	99-104
32802183-4	2020	To solve these problems, we designed oxygen-dual-generating nanosystems MnO2@Chitosan-CyI (MCC) for enhanced phototherapy.	Oxygen	37-43	cyclin I	Homo sapiens	86-89
32444495-3	2020	In this study, by bioinformatics analyses, we provide evidence for elevated expression of actin-binding protein PFN1 (profilin1) in the retinal vascular endothelial cells (VECs) of individuals with proliferative diabetic retinopathy, findings further supported by gene expression analyses for PFN1 in experimentally induced abnormal retinal neovascularization in an oxygen-induced retinopathy murine model.	Oxygen	366-372	profilin 1	Mus musculus	112-116
32444495-3	2020	In this study, by bioinformatics analyses, we provide evidence for elevated expression of actin-binding protein PFN1 (profilin1) in the retinal vascular endothelial cells (VECs) of individuals with proliferative diabetic retinopathy, findings further supported by gene expression analyses for PFN1 in experimentally induced abnormal retinal neovascularization in an oxygen-induced retinopathy murine model.	Oxygen	366-372	profilin 1	Mus musculus	118-127
32640421-4	2020	Moreover, high expression of GGT5 in CAFs enhanced the drug resistance of cancer cells by increasing intracellular glutathione and reducing the intracellular reactive oxygen species in cancer cells.	Oxygen	167-173	gamma-glutamyltransferase 5	Homo sapiens	29-33
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Oxygen	53-59	aurora kinase B	Homo sapiens	326-331
32857718-9	2020	In addition to increasing cell proliferation, OXT significantly blunted the rise in reactive oxygen species induced by H2O2, and antagonized the reductions in cell viability induced by H2O2 and camptothecin.	Oxygen	93-99	oxytocin/neurophysin I prepropeptide	Homo sapiens	46-49
33380153-3	2020	Methemoglobin has reduced ability to release oxygen to tissues and thereby leads to tissue hypoxia.	Oxygen	45-51	hemoglobin subunit gamma 2	Homo sapiens	0-13
32575773-2	2020	Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced neuroprotection following oxygen and glucose deprivation (OGD) in mouse cortical neurons.	Oxygen	285-291	hypocretin (orexin) receptor 1	Mus musculus	176-193
32193116-3	2020	The degradation of Fe(III)-EDTA was mostly attributed to an oxygen activation mechanism that involving O2- and hydroxyl radical (OH) generation, as validated by the quenching experiments and electron spin resonance.	Oxygen	60-66	immunoglobulin kappa variable 1D-39	Homo sapiens	103-127
32561926-8	2020	The oxygen consumption assays showed a severe impairment in basal respiration, Adenosine triphosphate-linked (ATP-linked) oxygen consumption, as well as reserve respiratory capacity, in RGCs from Opa1+/- mouse retina.	Oxygen	4-10	OPA1, mitochondrial dynamin like GTPase	Mus musculus	196-200
32561926-8	2020	The oxygen consumption assays showed a severe impairment in basal respiration, Adenosine triphosphate-linked (ATP-linked) oxygen consumption, as well as reserve respiratory capacity, in RGCs from Opa1+/- mouse retina.	Oxygen	122-128	OPA1, mitochondrial dynamin like GTPase	Mus musculus	196-200
31949294-5	2020	Further investigations showed that B10 treatment dose-dependently affected mitochondrial functions, including oxygen consumption rate (OCR), mitochondrial membrane potential (MMP) and the morphology of mitochondria in A549 cells.	Oxygen	110-116	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	35-38
32068268-5	2020	Moreover, down-regulation of FOXR2 inhibited hypoxia-induced reactive oxygen species (ROS) production and migration/invasion of TC cells.	Oxygen	70-76	forkhead box R2	Homo sapiens	29-34
32238418-9	2020	SIGNIFICANCE STATEMENT: Cytochrome P450 enzymes can be supported by different oxygen surrogates (OSs), avoiding the need for a redox partner and costly NADPH.	Oxygen	78-84	2,4-dienoyl-CoA reductase 1	Homo sapiens	152-157
32476808-5	2020	Interaction of AGE with RAGE generates reactive oxygen species, cytokines, and vascular cell adhesion molecules.	Oxygen	48-54	advanced glycosylation end-product specific receptor	Homo sapiens	24-28
31564537-11	2020	Notably, the conditioned medium from BV2 cells transfected with small interference RNA cold-inducible RNA-binding protein significantly reduced apoptosis in neural SH-SY5Y cells after oxygen-glucose deprivation, which was similar to that after JQ1 administration.	Oxygen	184-190	cold inducible RNA binding protein	Mus musculus	87-121
31823886-0	2020	Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation.	Oxygen	119-133	brain-derived neurotrophic factor	Rattus norvegicus	54-87
31823886-5	2020	Enzyme-linked immunosorbent assays and western blotting showed that after oxygen-glucose deprivation, the secreted and intracellular levels of BDNF were significantly reduced and the intracellular level of PC1/3 was decreased.	Oxygen	74-80	brain-derived neurotrophic factor	Rattus norvegicus	143-147
31823886-6	2020	Transient transfection of cortical neurons with a PC1/3 overexpression plasmid followed by oxygen-glucose deprivation resulted in increased PC1/3 levels and increased BDNF levels.	Oxygen	91-97	brain-derived neurotrophic factor	Rattus norvegicus	167-171
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	Oxygen	122-128	interleukin 21	Homo sapiens	75-80
32414764-8	2020	We show that MKP-1-deficient mice/macrophages exhibit, at baseline, higher expression of oxidative phosphorylation, TFAM, PGC-1alpha, and NRF-1 associated with increased respiration and production of reactive oxygen species as compared with wild-type mice.	Oxygen	209-215	dual specificity phosphatase 1	Mus musculus	13-18
31597194-9	2020	FRAS1-KO cells exhibited increased responsiveness to oxygen stress and diminished stemness, invasiveness, and migration.	Oxygen	53-59	Fraser extracellular matrix complex subunit 1	Homo sapiens	0-5
32429235-0	2020	AMPK and the Need to Breathe and Feed: What"s the Matter with Oxygen?	Oxygen	62-68	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4
32429235-3	2020	Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to the central regulation of feeding and food choice.	Oxygen	111-117	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	32-36
31488552-7	2020	Retroviral expression of VP16-HIF-1alpha in SCs increased HIF-alpha by 5.9-fold and its target genes implicated in oxygen transport and delivery (VEGF, 2.2-fold) and cellular metabolism (enolase, 1.7-fold).	Oxygen	115-121	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	30-40
33463260-7	2020	Furthermore, oxygen-loaded PAsp(DET)-PpIX-PEG nanovesicles could not only reduce therapeutic resistance by relieving tumor hypoxia but also increase ROS production for enhanced sonodynamic therapy.	Oxygen	13-19	carboxypeptidase B1	Homo sapiens	27-31
32035191-2	2020	TRPA-1 has been found to be overexpressed in various tumors, related to the tumor proliferation and metastasis, and promote reactive oxygen species (ROS) and chemotherapy tolerance through Ca2+-dependent anti-apoptotic pathway in recent studies, which provides a new anti-tumor approach to target oxidative-stress defense system.	Oxygen	133-139	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-6
32053194-0	2020	The calcineurin beta-like interacting protein kinase CIPK25 regulates potassium homeostasis under low oxygen in Arabidopsis.	Oxygen	102-108	CBL-interacting protein kinase 25	Arabidopsis thaliana	53-59
32053194-2	2020	We identified a member of the CALCINEURIN beta-LIKE INTERACTING PROTEIN KINASE (CIPK) family in Arabidopsis, CIPK25, which is induced in the root endodermis under low-oxygen conditions.	Oxygen	167-173	CBL-interacting protein kinase 25	Arabidopsis thaliana	109-115
32053194-5	2020	Under anoxic conditions, cipk25 mutant seedlings were unable to maintain potassium concentrations at wild-type levels, suggesting that CIPK25 likely plays a role in modulating potassium homeostasis under low-oxygen conditions.	Oxygen	208-214	CBL-interacting protein kinase 25	Arabidopsis thaliana	25-31
32053194-5	2020	Under anoxic conditions, cipk25 mutant seedlings were unable to maintain potassium concentrations at wild-type levels, suggesting that CIPK25 likely plays a role in modulating potassium homeostasis under low-oxygen conditions.	Oxygen	208-214	CBL-interacting protein kinase 25	Arabidopsis thaliana	135-141
31583505-6	2020	Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network.	Oxygen	95-101	von Hippel-Lindau tumor suppressor	Mus musculus	53-56
31825666-4	2020	Consistently, hypoxia/reoxygenation (H/R)-treated cardiac (H9c2) cells displayed cellular injury (apoptosis and necrosis), up-regulation of total and mitochondrial protein levels of Mul1 and p53, and enhanced interactions between p53 and SUMO1 concomitant with mitochondrial dysfunctions (increase in mitochondrial membrane potential and reactive oxygen species production while decrease in ATP production); these phenomena were attenuated by knockdown of Mul1 expression.	Oxygen	24-30	small ubiquitin-like modifier 1	Rattus norvegicus	238-243
31912910-7	2020	The increased reactive oxygen species production and decreased superoxide dismutase and glutathione peroxidase activities in H2 O2 -induced HCASMCs were reversed by GLA pretreatment.	Oxygen	23-29	galactosidase alpha	Homo sapiens	165-168
32565555-1	2020	Background: N-acetyltransferase-2 (NAT2) is a phase II xenobiotic enzyme that plays an important role against oxidative stress-mediated reactive oxygen species protection.	Oxygen	145-151	N-acetyltransferase 2	Homo sapiens	12-33
32565555-1	2020	Background: N-acetyltransferase-2 (NAT2) is a phase II xenobiotic enzyme that plays an important role against oxidative stress-mediated reactive oxygen species protection.	Oxygen	145-151	N-acetyltransferase 2	Homo sapiens	35-39
31893608-9	2020	This revealed that compound 4 coordinated with the Zn2+ ion in the hCAII active site through its methoxy oxygen at a distance of 1.60 A (FlexX) or 2.29 A (Swissdock).	Oxygen	97-111	carbonic anhydrase 2	Homo sapiens	67-72
32101225-6	2020	The thermal effect plays a dominant role in plasmon-catalyzed material transformation, and hot electrons can promote the oxidation reaction by facilitating the generation of active oxygen.	Oxygen	181-187	alcohol dehydrogenase iron containing 1	Homo sapiens	91-94
32391042-8	2020	Functional enrichment analysis showed that up-regulated DEGs and DELs" targets, including LDHA, PFKP, and VEGFA, were significantly enriched in biological processes related to hypoxia or oxygen levels, and the downregulated DEGs and DELs" targets were significantly enriched in extracellular-matrix-related biological processes.	Oxygen	187-193	delta 4-desaturase, sphingolipid 1	Homo sapiens	56-60
32391042-8	2020	Functional enrichment analysis showed that up-regulated DEGs and DELs" targets, including LDHA, PFKP, and VEGFA, were significantly enriched in biological processes related to hypoxia or oxygen levels, and the downregulated DEGs and DELs" targets were significantly enriched in extracellular-matrix-related biological processes.	Oxygen	187-193	phosphofructokinase, platelet	Homo sapiens	96-100
32391042-8	2020	Functional enrichment analysis showed that up-regulated DEGs and DELs" targets, including LDHA, PFKP, and VEGFA, were significantly enriched in biological processes related to hypoxia or oxygen levels, and the downregulated DEGs and DELs" targets were significantly enriched in extracellular-matrix-related biological processes.	Oxygen	187-193	delta 4-desaturase, sphingolipid 1	Homo sapiens	224-228
32308185-0	2021	A pilot study on the association between the blood oxygen level-dependent signal in the reward system and dopamine transporter availability in adults with attention deficit hyperactivity disorder.	Oxygen	51-57	solute carrier family 6 member 3	Homo sapiens	106-126
31891925-5	2020	The effect of surface adsorption of water vapor, oxygen, ammonia and isoprene gas phase molecules on the Ids was measured.	Oxygen	49-55	iduronate 2-sulfatase	Homo sapiens	105-108
31980131-2	2020	Studies for years have revealed that RISP is essential for the generation of intracellular reactive oxygen species (ROS) via delicate signaling pathways associated with many important molecules such as protein kinase C-epsilon, NADPH oxidase, and ryanodine receptors.	Oxygen	100-106	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	37-41
31838457-5	2020	To overcome the inherent drawback of GOx, namely, the use of oxygen as the electron acceptor, various glucose dehydrogenases (GDHs) have been utilized in second-generation principle-based sensors.	Oxygen	61-67	hydroxyacid oxidase 1	Homo sapiens	37-40
32058163-2	2020	In this study, we hypothesized that the reactive oxygen species (ROS)-mediated c-jun N-terminal kinase (JNK) signaling pathway is involved in anti-apoptosis of selenium against cadmium in TM3 cells.	Oxygen	49-55	mitogen-activated protein kinase 8	Mus musculus	79-102
32058163-2	2020	In this study, we hypothesized that the reactive oxygen species (ROS)-mediated c-jun N-terminal kinase (JNK) signaling pathway is involved in anti-apoptosis of selenium against cadmium in TM3 cells.	Oxygen	49-55	mitogen-activated protein kinase 8	Mus musculus	104-107
32125470-6	2020	Immunohistochemical stainings of NeuN, MAP2, GFAP, and IBA1 revealed a neuroprotective potency of post-ROSC ventilation with 21% O2, although it was only temporary.	Oxygen	129-131	glial fibrillary acidic protein	Rattus norvegicus	45-49
31650524-2	2020	p66Shc is an important protein adaptor that regulates production of reactive oxygen species (ROS) and induction of apoptosis, and is a novel biomarker for oxidative damage of renal tubules.	Oxygen	77-83	src homology 2 domain-containing transforming protein C1	Mus musculus	0-6
31694441-2	2020	This study aimed to investigate the neuroprotective action of BDNF overexpression in hippocampal neurons against injury under ischemia-like conditions (oxygen and glucose deprivation) and glutamate-induced excitotoxicity (GluTox).	Oxygen	152-158	brain derived neurotrophic factor	Homo sapiens	62-66
32233379-2	2020	When briefly accumulated in the Trap region of a Triwave cell in a SYNAPT G2 instrument, before being released for ion-mobility separation, these dehydroanilinium cations react readily with traces of oxygen present in the mobility gas to form peroxyl radical cations.	Oxygen	200-206	TRAP	Homo sapiens	32-36
31818057-8	2020	The maximum oxygen pulse was higher in the tests performed under beta-blockade (IET: DeltaVO2/HR: 3.1+-2.2 mL/beat, P<0.01; SST: DeltaVO2/HR: 3.4+-1.4 mL/beat, P<0.001).	Oxygen	12-18	somatostatin	Homo sapiens	124-127
31732720-6	2020	Furthermore, STAT1 phosphorylation and pathway activation is greater after IFN-alpha stimulation in Jak2V617F murine HSCs with increased induction of reactive oxygen species, DNA damage and reduction in quiescence after chronic IFN-alpha treatment.	Oxygen	159-165	signal transducer and activator of transcription 1	Mus musculus	13-18
31732720-6	2020	Furthermore, STAT1 phosphorylation and pathway activation is greater after IFN-alpha stimulation in Jak2V617F murine HSCs with increased induction of reactive oxygen species, DNA damage and reduction in quiescence after chronic IFN-alpha treatment.	Oxygen	159-165	interferon alpha	Mus musculus	75-84
32169478-4	2020	In turn, CtBP2 has been associated with neurodevelopment and neurological disease, and we have shown that CtBP2 acetylation and dimerization, required for proper transcriptional activity, are regulated by microenvironmental oxygen levels.	Oxygen	224-230	C-terminal binding protein 2	Mus musculus	9-14
32169478-4	2020	In turn, CtBP2 has been associated with neurodevelopment and neurological disease, and we have shown that CtBP2 acetylation and dimerization, required for proper transcriptional activity, are regulated by microenvironmental oxygen levels.	Oxygen	224-230	C-terminal binding protein 2	Mus musculus	106-111
32001079-3	2020	Within the central nervous system, MMP-9 is localized and released from neurons, astrocytes and microglia where its expression levels are modulated by cytokines and growth factors during both normal and pathological conditions as well as by reactive oxygen species generated during oxidative stress.	Oxygen	250-256	matrix metallopeptidase 9	Homo sapiens	35-40
32179690-6	2020	The structure, along with additional high-resolution crystal structures of several analogs in complex with RalA, confirm the importance of key hydrogen bond anchors between compound sulfone oxygen atoms and Ral backbone nitrogen atoms.	Oxygen	190-196	RAS like proto-oncogene A	Homo sapiens	107-111
32179690-6	2020	The structure, along with additional high-resolution crystal structures of several analogs in complex with RalA, confirm the importance of key hydrogen bond anchors between compound sulfone oxygen atoms and Ral backbone nitrogen atoms.	Oxygen	190-196	RAN pseudogene 1	Homo sapiens	107-110
32197638-11	2020	Interestingly, VEGF knockdown in 1%O2 MSCs attenuated HGF secretion and the inhibition of TGF-beta1-induced fibrotic changes in HK-2 cells.	Oxygen	35-37	hepatocyte growth factor	Rattus norvegicus	54-57
32059109-1	2020	The recombination dynamics of $^3$P oxygen atoms on cold amorphous solid water to form triplet and singlet molecular oxygen (O$_2$) is investigated under conditions representative for cold clouds.	Oxygen	36-42	immunoglobulin kappa variable 1D-39	Homo sapiens	125-130
32059109-1	2020	The recombination dynamics of $^3$P oxygen atoms on cold amorphous solid water to form triplet and singlet molecular oxygen (O$_2$) is investigated under conditions representative for cold clouds.	Oxygen	117-123	immunoglobulin kappa variable 1D-39	Homo sapiens	125-130
32256638-7	2020	It reversed the oxygen-glucose deprivation/reoxygenation- (OGD/R-) induced downregulation of DOR mRNA and protein, as well as BDNF protein.	Oxygen	16-22	brain-derived neurotrophic factor	Rattus norvegicus	126-130
31927091-3	2020	According to the estimation of relative contributions involved in E-PDS process, reactive oxygen species (ROS), especially sulfate radical (SO4 -), played a dominant role in the degradation of phenol and its byproducts.	Oxygen	90-96	solute carrier family 26 member 4	Homo sapiens	68-71
32183322-11	2020	The in vitro study showed that short-term hyperoxia exposure (80% O2) of TNBC cells increases ROS, increases BDNF expression and that promotes EMT and angiogenesis.	Oxygen	66-68	brain derived neurotrophic factor	Homo sapiens	109-113
32215270-0	2020	CCAAT/Enhancer-Binding Protein beta Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.	Oxygen	45-51	CCAAT/enhancer binding protein beta	Rattus norvegicus	0-35
32001619-5	2020	Here, using several human lung cancer cell lines, siRNA-mediated gene silencing, immunoblotting, quantitative RT-PCR, promoter-reporter assays and reactive oxygen species (ROS) assays, we demonstrate that KRAS maintains low P53 levels by activating the NFE2-related factor 2 (NRF2)-regulated antioxidant defense system.	Oxygen	156-162	KRAS proto-oncogene, GTPase	Homo sapiens	205-209
32309380-0	2020	Prenatal dexamethasone exposure exerts sex-specific effect on placental oxygen and nutrient transport ascribed to the differential expression of IGF2.	Oxygen	72-78	insulin-like growth factor 2	Rattus norvegicus	145-149
31756327-7	2020	OXY was also observed to induce the production of reactive oxygen species, which caused the depolarization of the mitochondrial membrane resulting in translocation of Apoptosis Inducing Factor (AIF) into the nucleus.	Oxygen	59-65	apoptosis inducing factor mitochondria associated 1	Homo sapiens	167-192
31756327-7	2020	OXY was also observed to induce the production of reactive oxygen species, which caused the depolarization of the mitochondrial membrane resulting in translocation of Apoptosis Inducing Factor (AIF) into the nucleus.	Oxygen	59-65	apoptosis inducing factor mitochondria associated 1	Homo sapiens	194-197
31794767-6	2020	S100 proteins are released from monocytes, smooth muscle cells and endothelial cells in response to cellular stress stimuli, and then the binding of S100 proteins to RAGE activate downstream signaling such as transcription factor kappa B (NF-kappaB) translocation and reactive oxygen species (ROS) production, which act as a positive feedback loop for inducing pro-inflammatory phenotype in a wide variety of cell types including endothelial cells, vascular smooth muscle cells and leukocytes.	Oxygen	277-283	long intergenic non-protein coding RNA 914	Homo sapiens	166-170
32006211-6	2020	In this review, we summarize the evidence outlining the effects of n-3 long-chain PUFA and highly fermentable fiber with respect to alterations in critical pathways important to CRC prevention, particularly intrinsic mitochondrial-mediated programmed cell death resulting from the accumulation of lipid reactive oxygen species (ferroptosis), and epigenetic programming related to lipid catabolism and beta-oxidation-associated genes.	Oxygen	312-318	pumilio RNA binding family member 3	Homo sapiens	82-86
31944402-5	2020	Meanwhile, Me1 played a role in maintaining mitochondrial function as indicated by these observations that blockadge of Me1 led to the accumulation of mitochondrial O 2 -  level and decreased ATP production and mtDNA copy numbers accompanied with defective mitochondrial membrane potential.	Oxygen	165-168	malic enzyme 1	Homo sapiens	11-14
31944402-5	2020	Meanwhile, Me1 played a role in maintaining mitochondrial function as indicated by these observations that blockadge of Me1 led to the accumulation of mitochondrial O 2 -  level and decreased ATP production and mtDNA copy numbers accompanied with defective mitochondrial membrane potential.	Oxygen	165-168	malic enzyme 1	Homo sapiens	120-123
31932725-3	2020	We engineered LOXCAT, a fusion of bacterial lactate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and water.	Oxygen	126-132	lysyl oxidase	Homo sapiens	14-17
32048687-2	2020	Opto-Rac1 is a fusion of wildtype human Rac1 small GTPase to the C-terminal region of BcLOV4, a LOV (light-oxygen-voltage) photoreceptor that rapidly binds the plasma membrane upon blue-light activation via a direct electrostatic interaction with anionic membrane phospholipids.	Oxygen	107-113	Rac family small GTPase 1	Homo sapiens	5-9
31961241-0	2020	Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging.	Oxygen	6-12	spindlin 1	Homo sapiens	80-84
32098974-14	2020	The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II.	Oxygen	10-16	endothelin-1	Oryctolagus cuniculus	73-88
31961357-7	2020	Instead, in pdx1.3-1, the antioxidant capacity significantly decreased by 44-52% over the same time period, proving the importance of a full complement of functional PDX1 genes for the detoxification of reactive oxygen species.	Oxygen	212-218	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	12-16
31961357-7	2020	Instead, in pdx1.3-1, the antioxidant capacity significantly decreased by 44-52% over the same time period, proving the importance of a full complement of functional PDX1 genes for the detoxification of reactive oxygen species.	Oxygen	212-218	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	166-170
32065781-6	2020	Inhibition of MEG3 remarkably increased the expression of miR-424-5p and decreased the expression of Sema3A, which also led to in an increased cell viability and decreased cellular apoptosis in oxygen-glucose deprivation and reoxygenation (OGD/R) model, as well as an activated MAPK signaling pathways.	Oxygen	194-200	semaphorin 3A	Rattus norvegicus	101-107
31606706-0	2020	Controllable incorporation of oxygen in MoS2 for efficient adsorption of Hg2+ in aqueous solutions.	Oxygen	30-36	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	73-76
31606706-1	2020	Molybdenum disulfide (MoS2) was incorporated controllably by oxygen in order to modify the hydrophobic surfaces and thus to improve the adsorption of Hg2+ on MoS2 in aqueous solutions in this work.	Oxygen	61-67	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	150-153
31606706-2	2020	The experimental results indicated that the incorporation of oxygen could dramatically improve the adsorption of Hg2+ on MoS2.	Oxygen	61-67	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	113-116
31606706-4	2020	This vast improvement was found to be contributed to that the incorporation of oxygen would greatly enhance the complexation between S atoms and Hg2+ on MoS2 surfaces, resulting in the great increase of the Hg2+ adsorption.	Oxygen	79-85	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	145-148
31606706-4	2020	This vast improvement was found to be contributed to that the incorporation of oxygen would greatly enhance the complexation between S atoms and Hg2+ on MoS2 surfaces, resulting in the great increase of the Hg2+ adsorption.	Oxygen	79-85	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	207-210
31606706-6	2020	In addition, the incorporation of oxygen atom greatly enhanced the hydrophilicity of MoS2 surfaces, facilitating the hydrated Hg2+ ions to approach to MoS2 surfaces.	Oxygen	34-40	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	126-129
32013948-0	2020	Rapamycin prevents retinal neovascularization by downregulation of cyclin D1 in a mouse model of oxygen-induced retinopathy.	Oxygen	97-103	cyclin D1	Mus musculus	67-76
31662347-4	2020	Tumor cells induced the expression of TIPE2 in Gr1+CD11b+ cells through reactive oxygen species (ROS).	Oxygen	81-87	TNF alpha induced protein 8 like 2	Homo sapiens	38-43
31662347-4	2020	Tumor cells induced the expression of TIPE2 in Gr1+CD11b+ cells through reactive oxygen species (ROS).	Oxygen	81-87	integrin subunit alpha M	Homo sapiens	51-56
31845272-4	2020	An oxygen delignification stage before D0EOPD bleaching sequence reduced the AOX, COD, colour and BOD by 44%, 42%, 36% and 33%, respectively, whereas an ozonation stage before bleaching reduced the same by 70%, 66%, 73% and 60%, respectively, as compared to those of control.	Oxygen	3-9	acyl-CoA oxidase 1	Homo sapiens	77-80
31927658-3	2020	In the current study, we found that the long non-coding RNA (lncRNA) FAL1 was significantly reduced in response to oxygen-glucose deprivation and reoxygenation (OGD/R) stimulation in human primary brain microvascular endothelial cells (HBMVECs).	Oxygen	115-121	focally amplified long non-coding RNA in epithelial cancer	Homo sapiens	69-73
31282750-2	2020	However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy.	Oxygen	13-19	hydroxyacid oxidase 1	Homo sapiens	51-66
31282750-2	2020	However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy.	Oxygen	13-19	hydroxyacid oxidase 1	Homo sapiens	68-71
31950451-7	2020	In vitro, oxygen-glucose deprivation/refusion (OGD/R) stimulation on PC-12 cells significantly increased NOX2 protein levels, ROS production, and the cell apoptosis, while a significant suppression on SOD activity; OGD/R stimulation-induced changes in PC-12 cells described above could be significantly attenuated by NOX2 silence.	Oxygen	10-24	cytochrome b-245 beta chain	Rattus norvegicus	105-109
31950451-7	2020	In vitro, oxygen-glucose deprivation/refusion (OGD/R) stimulation on PC-12 cells significantly increased NOX2 protein levels, ROS production, and the cell apoptosis, while a significant suppression on SOD activity; OGD/R stimulation-induced changes in PC-12 cells described above could be significantly attenuated by NOX2 silence.	Oxygen	10-24	cytochrome b-245 beta chain	Rattus norvegicus	317-321
31956152-6	2020	In a univariate analysis, BDNF was significantly correlated with the peak oxygen uptake, estimated glomerular filtration rate, 10-m gait speed, and muscle strength, but not with the body mass index or lean mass in the HF group.	Oxygen	74-80	brain derived neurotrophic factor	Homo sapiens	26-30
31759628-4	2020	This study aimed to evaluate the role of vascular endothelial growth factor-A (VEGFA)-PLVAP axis in the maintenance of choroidal fenestrations using oxygen-induced retinopathy (OIR) model.	Oxygen	149-155	vascular endothelial growth factor A	Mus musculus	41-77
31759628-4	2020	This study aimed to evaluate the role of vascular endothelial growth factor-A (VEGFA)-PLVAP axis in the maintenance of choroidal fenestrations using oxygen-induced retinopathy (OIR) model.	Oxygen	149-155	vascular endothelial growth factor A	Mus musculus	79-84
31837296-5	2020	HIPK2 depletion by small interfering RNA (siRNA)-mediated gene silencing significantly decreased the viability and exacerbated H/R-induced apoptosis and reactive oxygen species (ROS) production in cardiomyocytes.	Oxygen	162-168	homeodomain interacting protein kinase 2	Homo sapiens	0-5
31871275-0	2020	Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activity.	Oxygen	4-10	lysyl oxidase	Homo sapiens	120-123
31871275-6	2020	Low oxygen-induced EVT differentiation coincided with elevated transcriptomic levels of lysyl oxidase (LOX) in trophoblast anchoring columns, in which functional experiments established a role for LOX activity in promoting EVT column outgrowth.	Oxygen	4-10	lysyl oxidase	Homo sapiens	88-101
31871275-6	2020	Low oxygen-induced EVT differentiation coincided with elevated transcriptomic levels of lysyl oxidase (LOX) in trophoblast anchoring columns, in which functional experiments established a role for LOX activity in promoting EVT column outgrowth.	Oxygen	4-10	lysyl oxidase	Homo sapiens	103-106
31871275-6	2020	Low oxygen-induced EVT differentiation coincided with elevated transcriptomic levels of lysyl oxidase (LOX) in trophoblast anchoring columns, in which functional experiments established a role for LOX activity in promoting EVT column outgrowth.	Oxygen	4-10	lysyl oxidase	Homo sapiens	197-200
31969132-14	2020	Improvements in fitness (maximal respiratory exchange ratio and maximal oxygen consumption during GXT) were associated with increased brain-derived neurotrophic factor and decreased interleukin-6.	Oxygen	72-78	brain derived neurotrophic factor	Homo sapiens	134-167
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	Oxygen	98-104	antioxidant 1 copper chaperone	Homo sapiens	34-39
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	Oxygen	98-104	antioxidant 1 copper chaperone	Homo sapiens	152-157
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	Oxygen	98-104	neutrophil cytosolic factor 1	Homo sapiens	202-210
31613081-5	2020	Linking our molecular model to cellular assays, we demonstrate that this "distorted binding mode" facilitates a deleterious cellular accumulation of reactive oxygen species that could represent the molecular origin of Lcn2 pathology.	Oxygen	158-164	lipocalin 2	Homo sapiens	218-222
31859299-1	2020	A tough and transparent norbornene copolymer film affixing an imidazolyl iron-salen complex catalyst exhibited an ultra-high, humidity-independent, and monthly paced oxygen-scavenging capacity up to 300 mL (oxygen gas at STP)/g(film).	Oxygen	166-172	thyroid hormone receptor interactor 10	Homo sapiens	221-224
31859299-1	2020	A tough and transparent norbornene copolymer film affixing an imidazolyl iron-salen complex catalyst exhibited an ultra-high, humidity-independent, and monthly paced oxygen-scavenging capacity up to 300 mL (oxygen gas at STP)/g(film).	Oxygen	207-213	thyroid hormone receptor interactor 10	Homo sapiens	221-224
31606465-8	2020	STC-1 gene expression, which could decrease the apoptosis rate and reactive oxygen species production to significantly increase the cell membrane potential and reduce the formation of intracellular ATP, which also affected the morphology and number of mitochondria.	Oxygen	76-82	stanniocalcin 1	Sus scrofa	0-5
32411331-0	2020	Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells.	Oxygen	32-38	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	68-80
31689671-8	2020	As a potential P source, the massive accumulation of Fe/Al-P and Po would be released into the overlying water to further facilitate eutrophication via increasing pH and alkaline phosphatase and decreasing in the dissolved oxygen concentration.	Oxygen	223-229	PDZ and LIM domain 3	Homo sapiens	56-60
31618435-2	2020	Hypoxia-inducible transcription factor prolyl hydroxylase-containing enzymes (PHD1, PHD2, and PHD3) are molecular oxygen sensors that control adaptive gene expression through hypoxia-inducible factor (HIF).	Oxygen	114-120	egl-9 family hypoxia inducible factor 3	Homo sapiens	94-98
32138537-8	2020	The western blot and real-time PCR data revealed that hypoxic stress with 2.5% O2 suppressed the expression of miR-145 and Wnt3a/beta-catenin in cultured rat cardiomyocytes but augmented Dab2.	Oxygen	79-81	DAB adaptor protein 2	Rattus norvegicus	187-191
32002042-9	2020	SP-D showed a negative correlation with percutaneous oxygen saturation and positive correlations with serum lactate dehydrogenase, Krebs von den Lungen (KL)-6, and percentage of lymphocytes in bronchoalveolar lavage (BAL).	Oxygen	53-59	surfactant protein D	Homo sapiens	0-4
31619060-14	2020	Remarkably, inactivation of GC-A in pericytes retarded physiological retinal vascularization and markedly enhanced cell apoptosis, vascular regression, and subsequent neovascularization in oxygen-induced retinopathy.	Oxygen	189-195	natriuretic peptide receptor 1	Mus musculus	28-32
31669487-2	2020	The importance of the two PsaE isoforms of photosystem I, PsaE1 and PsaE2, for O2 reduction was studied in plants grown under these different growth regimes.	Oxygen	79-81	Photosystem I reaction centre subunit IV / PsaE protein	Arabidopsis thaliana	58-63
31669487-2	2020	The importance of the two PsaE isoforms of photosystem I, PsaE1 and PsaE2, for O2 reduction was studied in plants grown under these different growth regimes.	Oxygen	79-81	photosystem I subunit E-2	Arabidopsis thaliana	68-73
31669487-3	2020	In short day conditions a mutant affected in the amount of PsaE1 (psae1-1) reduced more efficiently O2 than a mutant lacking PsaE2 (psae2-1) as shown by spin trapping EPR spectroscopy on leaves and by following the kinetics of P700+ reduction in isolated photosystem I.	Oxygen	100-102	Photosystem I reaction centre subunit IV / PsaE protein	Arabidopsis thaliana	59-64
31669487-3	2020	In short day conditions a mutant affected in the amount of PsaE1 (psae1-1) reduced more efficiently O2 than a mutant lacking PsaE2 (psae2-1) as shown by spin trapping EPR spectroscopy on leaves and by following the kinetics of P700+ reduction in isolated photosystem I.	Oxygen	100-102	Photosystem I reaction centre subunit IV / PsaE protein	Arabidopsis thaliana	66-73
31669487-4	2020	In short day conditions higher O2 reduction protected photosystem II against photoinhibition in psae1-1.	Oxygen	31-33	Photosystem I reaction centre subunit IV / PsaE protein	Arabidopsis thaliana	96-103
31738973-1	2020	This study was designed to investigate whether calcium-sensing receptor (CaSR) could induce immture white matter progenitor cells proliferation and differentiation into oligodendrocyte(OL) precursor cells after oxygen-glucose deprivation (OGD) in vitro.	Oxygen	211-217	calcium-sensing receptor	Rattus norvegicus	47-71
31738973-1	2020	This study was designed to investigate whether calcium-sensing receptor (CaSR) could induce immture white matter progenitor cells proliferation and differentiation into oligodendrocyte(OL) precursor cells after oxygen-glucose deprivation (OGD) in vitro.	Oxygen	211-217	calcium-sensing receptor	Rattus norvegicus	73-77
31573955-11	2020	FES depletion promoted radiation-induced reactive oxygen species formation, which resulted in phosphorylation of S6K and MDM2.	Oxygen	50-56	MDM2 proto-oncogene	Homo sapiens	121-125
31654521-7	2020	Additionally, reports show that 2-APB exerts effects on neurons, smooth muscle cells and cardiomyocytes, and it provides a cytoprotective effect by modulation and attenuation of reactive oxygen species.	Oxygen	187-193	arginyl aminopeptidase	Homo sapiens	34-37
33130681-0	2020	miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3.	Oxygen	33-39	receptor interacting serine/threonine kinase 3	Homo sapiens	103-107
31730933-0	2020	NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension.	Oxygen	22-28	cytochrome b-245 beta chain	Rattus norvegicus	0-4
31730933-1	2020	Previous studies utilizing the SSp67phox-/- rat have demonstrated the importance of systemic NADPH oxidase NOX2-derived reactive oxygen species (ROS) production in the pathogenesis of Dahl Salt-Sensitive (SS) hypertension and renal damage.	Oxygen	129-135	cytochrome b-245 beta chain	Rattus norvegicus	107-111
31942176-12	2020	CBR1 inhibition increased levels of intracellular reactive oxygen species (ROS) in HNSCC cells leading to upregulation of beta-catenin, one of main transcription factors that induce EMT-related genes.	Oxygen	59-65	carbonyl reductase 1	Homo sapiens	0-4
31210352-4	2020	The purpose of the study aimed to probe the functions of miR-132 in oxygen and glucose deprivation (OGD)-evoked injury in H9c2 cells.	Oxygen	68-74	microRNA 132	Rattus norvegicus	57-64
31707353-8	2020	Impaired inflammasome activation in G6PD-kd THP-1 cells was mediated by a decrease in the production of reactive oxygen species (ROS) by NOX signaling, while treatment with hydrogen peroxide (H2O2) enhanced inflammasome activation in G6PD-kd THP-1 cells.	Oxygen	113-119	glucose-6-phosphate dehydrogenase	Homo sapiens	36-40
31539803-0	2020	The NOTCH1-dependent HIF1alpha/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation.	Oxygen	45-51	notch receptor 1a	Danio rerio	4-10
31539803-8	2020	Our study also indicates that VGLL4 is a key player in the mediation of NOTCH1-dependent HIF1alpha-regulated erythropoiesis and can be sensitively regulated by oxygen concentrations.	Oxygen	160-166	notch receptor 1a	Danio rerio	72-78
31629659-0	2019	KDM3A Senses Oxygen Availability to Regulate PGC-1alpha-Mediated Mitochondrial Biogenesis.	Oxygen	13-19	lysine (K)-specific demethylase 3A	Mus musculus	0-5
31629659-4	2019	Hypoxic stimulation inhibits KDM3A, which has a high KM of oxygen for its activity, and enhances PGC-1alpha K224 monomethylation.	Oxygen	59-65	lysine (K)-specific demethylase 3A	Mus musculus	29-34
31629659-7	2019	This study revealed that PGC-1alpha monomethylation, which is dependent on oxygen availability-regulated KDM3A, plays a critical role in the regulation of mitochondrial biogenesis.	Oxygen	75-81	lysine (K)-specific demethylase 3A	Mus musculus	105-110
31602731-3	2019	ADR is equipped with chemiluminescence and near-infrared fluorescence (NIRF) signaling channels that can be activated by oxidative stress (superoxide anion, O2 .- ) and lysosomal damage (N-acetyl-beta-d-glucosaminidase, NAG), respectively.	Oxygen	157-159	neuroblastoma amplified sequence	Mus musculus	220-223
31871542-0	2019	NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells.	Oxygen	24-30	cytochrome b-245 beta chain	Homo sapiens	0-4
30945565-3	2019	The present study was designed to evaluate whether the polymerized porcine haemoglobin (pPolyHb), a novel type of haemoglobin oxygen carrier, has an effect on I/R injury via regulating the Pink1-Parkin mediated mitochondrial autophagy pathway in myocardial H9C2 cells.	Oxygen	126-132	PTEN induced kinase 1	Rattus norvegicus	189-194
31590128-1	2019	OBJECTIVE: The study was established to inquire into the protective effect of the HIF-1alpha (Hypoxia-inducible factor-1alpha)/ BNIP3(Bcl-2/adenovirus E1B 19-kDa interacting protein) signal path-induced-autophagy during myocardial ischemia/ reperfusion (I/R) and oxygen-glucose deprivation/recovery (OGD/R) injury in heart-derived H9C2 cells as well as its potential underlying mechanism.	Oxygen	263-269	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	82-92
31590128-1	2019	OBJECTIVE: The study was established to inquire into the protective effect of the HIF-1alpha (Hypoxia-inducible factor-1alpha)/ BNIP3(Bcl-2/adenovirus E1B 19-kDa interacting protein) signal path-induced-autophagy during myocardial ischemia/ reperfusion (I/R) and oxygen-glucose deprivation/recovery (OGD/R) injury in heart-derived H9C2 cells as well as its potential underlying mechanism.	Oxygen	263-269	BCL2 interacting protein 3	Rattus norvegicus	128-133
30132384-3	2019	MOAP-1 overexpressing SH-SY5Y cells showed significantly lower cell viability following oxygen and glucose deprivation (OGD) treatment when compared to control cells.	Oxygen	88-94	modulator of apoptosis 1	Homo sapiens	0-6
31484706-9	2019	Synergy of 4-HPR + ABT-199 was mediated by induction of NOXA via 4-HPR stimulation of reactive oxygen species that induced expression of ATF4 and ATF3, transcription factors for NOXA.	Oxygen	95-101	activating transcription factor 4	Homo sapiens	137-141
31885781-10	2019	In conclusion, HIF-1alpha, F2RL1, and PIK3CB may act as novel drivers for vitiligo, which are all closely associated with reactive oxygen species and possibly contribute to the activation and/or migration of melanocyte-specific CD8+ T cells in vitiligo.	Oxygen	131-137	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	38-44
31885781-10	2019	In conclusion, HIF-1alpha, F2RL1, and PIK3CB may act as novel drivers for vitiligo, which are all closely associated with reactive oxygen species and possibly contribute to the activation and/or migration of melanocyte-specific CD8+ T cells in vitiligo.	Oxygen	131-137	CD8a molecule	Homo sapiens	228-231
31752076-3	2019	In this study, a proteomics analysis has revealed a decrease in the serum S100A9 level in patients with ONFH upon hyperbaric oxygen therapy.	Oxygen	125-131	S100 calcium binding protein A9	Homo sapiens	74-80
31542478-4	2019	A genetic or pharmacological inhibition of AMPK increased MPP+-triggered production of reactive oxygen species and cell death, and diminished Akt phosphorylation, while AMPK activation protected SH-SY5Y cells from MPP+.	Oxygen	96-102	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	43-47
31781169-0	2019	Translated Long Non-Coding Ribonucleic Acid ZFAS1 Promotes Cancer Cell Migration by Elevating Reactive Oxygen Species Production in Hepatocellular Carcinoma.	Oxygen	103-109	ZNFX1 antisense RNA 1	Homo sapiens	44-49
31781169-7	2019	Functional studies revealed that ZFAS1 can promote cancer cell migration by elevating intracellular reactive oxygen species production by inhibiting nicotinamide adenine dinucleotide dehydrogenase expression, indicating that translated ZFAS1 may be an essential oncogene in the progression of HCC.	Oxygen	109-115	ZNFX1 antisense RNA 1	Homo sapiens	33-38
31781040-2	2019	Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species.	Oxygen	188-194	glutathione peroxidase 1	Homo sapiens	0-24
31781040-2	2019	Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen peroxide into water, preventing cellular injury from reactive oxygen species.	Oxygen	188-194	glutathione peroxidase 1	Homo sapiens	26-30
31389735-8	2019	Scavenging superoxide (0.5muM TEMPO or mitoTEMPO) maintained the expression of contractile phenotype proteins Calponin and SM22alpha decreased by 48hrs hypoxia (1% oxygen).	Oxygen	164-170	transgelin	Bos taurus	123-132
31343586-9	2019	Peak oxygen uptake on day 30 was also higher in G1 and G2 (P = .005).	Oxygen	5-11	proline rich protein BstNI subfamily 3	Homo sapiens	48-57
31701004-0	2019	Spin-orbit torque manipulated by fine-tuning of oxygen-induced orbital hybridization.	Oxygen	48-54	spindlin 1	Homo sapiens	0-4
31701004-4	2019	Here, we demonstrate a marked enhancement of the spin-orbit torque induced by a fine-tuning of oxygen-induced modification of orbital hybridization.	Oxygen	95-101	spindlin 1	Homo sapiens	49-53
31583830-0	2019	Oxygen Vacancy-Engineered PEGylated MoO3 -x Nanoparticles with Superior Sulfite Oxidase Mimetic Activity for Vitamin B1 Detection.	Oxygen	0-6	sulfite oxidase	Homo sapiens	72-87
31583830-3	2019	Herein, a SuOx mimic nanozyme of PEGylated (polyethylene glycol)-MoO3 -x nanoparticles (P-MoO3 -x NPs) with abundant oxygen vacancies created by vacancy-engineering is reported.	Oxygen	117-123	sulfite oxidase	Homo sapiens	10-14
31720532-4	2019	The response of the SOI-GOx working electrode was significantly higher in the presence of oxygen than that without oxygen, indicating that a hydrogen peroxide pathway dominated in our SOI-GOx electrode.	Oxygen	90-96	hydroxyacid oxidase 1	Homo sapiens	24-27
31720532-4	2019	The response of the SOI-GOx working electrode was significantly higher in the presence of oxygen than that without oxygen, indicating that a hydrogen peroxide pathway dominated in our SOI-GOx electrode.	Oxygen	90-96	hydroxyacid oxidase 1	Homo sapiens	188-191
31720532-4	2019	The response of the SOI-GOx working electrode was significantly higher in the presence of oxygen than that without oxygen, indicating that a hydrogen peroxide pathway dominated in our SOI-GOx electrode.	Oxygen	115-121	hydroxyacid oxidase 1	Homo sapiens	24-27
31720532-4	2019	The response of the SOI-GOx working electrode was significantly higher in the presence of oxygen than that without oxygen, indicating that a hydrogen peroxide pathway dominated in our SOI-GOx electrode.	Oxygen	115-121	hydroxyacid oxidase 1	Homo sapiens	188-191
31625633-0	2019	Understanding the Role of Solvents and Spin-Orbit Coupling in an Aerial Oxygen Assisted SN2 Type Oxidative Transmetalation Reaction.	Oxygen	72-78	spindlin 1	Homo sapiens	39-43
31126732-2	2019	Several lines of evidence support a role for oxidative stress in atherogenesis and NADPH oxidase-2 (NOX-2) is considered a major source of O2- in human.	Oxygen	139-142	cytochrome b-245 beta chain	Homo sapiens	100-105
31498991-2	2019	For this purpose, a recently reported methodology that employs the enzyme glucose oxidase (GOx) to deplete oxygen in reaction media was utilized.	Oxygen	107-113	hydroxyacid oxidase 1	Homo sapiens	74-89
31498991-2	2019	For this purpose, a recently reported methodology that employs the enzyme glucose oxidase (GOx) to deplete oxygen in reaction media was utilized.	Oxygen	107-113	hydroxyacid oxidase 1	Homo sapiens	91-94
31412510-2	2019	The chemical nature of the organic scaffold and the type and abundance of oxygen-containing functional groups of the synthetic humic substances (A-FA and A-HA) are revealed by a series of examinations.	Oxygen	74-80	AFA	Homo sapiens	145-149
31597291-5	2019	Our data show that cd47 null irradiated lung tissue activates a unique set of metabolic pathways that facilitate the handling of reactive oxygen species, lipid metabolism, nucleotide metabolism and nutrient metabolites which may be regulated by microbial processing.	Oxygen	138-144	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	19-23
31278950-6	2019	Additionally, attenuated SDH activity following SDHC knockdown promoted HCC-cell growth and metastasis both in vitro and in vivo via elevated reactive oxygen species levels and subsequent activation of nuclear factor-kappaB signaling.	Oxygen	151-157	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
30819907-1	2019	The Shc family adaptor p66Shc acts as a negative regulator of proliferative and survival signals triggered by the B-cell receptor and, by enhancing the production of reactive oxygen species, promotes oxidative stress-dependent apoptosis.	Oxygen	175-181	src homology 2 domain-containing transforming protein C1	Mus musculus	4-7
30819907-1	2019	The Shc family adaptor p66Shc acts as a negative regulator of proliferative and survival signals triggered by the B-cell receptor and, by enhancing the production of reactive oxygen species, promotes oxidative stress-dependent apoptosis.	Oxygen	175-181	src homology 2 domain-containing transforming protein C1	Mus musculus	23-29
31009765-4	2019	Although OT exerted no direct effect on perceived pain, OT was found to modulate the blood oxygen level-dependent response in the ventral striatum for painful versus warm unconditioned stimuli and to decrease activity in the anterior insula (IS) with repeated thermal pain stimuli.	Oxygen	91-97	oxytocin/neurophysin I prepropeptide	Homo sapiens	56-58
31581560-9	2019	Although there was limited dissolved oxygen, aerobic degrading genes AlkB and Cdo were more abundant than anaerobic degrading genes AssA and BssA.	Oxygen	37-43	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	69-73
31201114-8	2019	Our results indicate that loss of Nf1 stimulates PKCdelta-mediated p47phox phosphorylation via RAS activation, leading to increased NADPH oxidase 2 activity, reactive oxygen species generation, membrane ruffling and macropinocytosis.	Oxygen	167-173	protein kinase C, delta	Mus musculus	49-57
31384852-5	2019	When TYR was applied to the probe Cy-tyr, the phenolic hydroxyl group was oxidized to achieve o-benzoquinone in the presence of oxygen, and the resulting cyanine products exhibited a strong tendency to undergo H-aggregation.	Oxygen	128-134	tyrosinase	Homo sapiens	5-8
31384852-5	2019	When TYR was applied to the probe Cy-tyr, the phenolic hydroxyl group was oxidized to achieve o-benzoquinone in the presence of oxygen, and the resulting cyanine products exhibited a strong tendency to undergo H-aggregation.	Oxygen	128-134	tyrosinase	Homo sapiens	37-40
31484989-6	2019	To address this hypothesis, we combined the Mcp1 model with xenotopic expression of the alternative oxidase (AOX), which provides a sink for electrons blocked from passage to oxygen via respiratory complexes III and IV.	Oxygen	175-181	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	88-107
31294524-2	2019	A paradigmatic case is represented by open-shell metals supported on oxides, where the catalytic properties crucially depend on the nature of the metal-oxygen bonds and the extent of charge and spin transfer.	Oxygen	152-158	spindlin 1	Homo sapiens	194-198
31294524-4	2019	We show that just a few selected sites out of all possible are populated and that the relative occupancies depend on the specific properties of the metal, and we provide maps of charge and spin transfer at the metal-oxygen interface.	Oxygen	216-222	spindlin 1	Homo sapiens	189-193
31301453-12	2019	Both SRI and BZD groups were associated with smaller seizure-associated oxygen desaturation (p = 0.009; p &lt;&lt; 0.001).	Oxygen	72-78	sorcin	Homo sapiens	5-8
31325723-2	2019	NADPH oxidase type 2 (NOX2) is a respiratory burst oxidase that generates large amounts of superoxide anion (O2 -) and subsequent other reactive oxygen species (ROS).	Oxygen	109-113	cytochrome b-245 beta chain	Homo sapiens	0-20
31325723-2	2019	NADPH oxidase type 2 (NOX2) is a respiratory burst oxidase that generates large amounts of superoxide anion (O2 -) and subsequent other reactive oxygen species (ROS).	Oxygen	109-113	cytochrome b-245 beta chain	Homo sapiens	22-26
31374171-5	2019	In addition to efficient removal of H2O2 for self-protection of normal tissues via antioxidation, GOx/TPZ-coloaded HMBRN can also rapidly deplete intratumoral glucose/oxygen to promote a synergistic starvation-enhanced bioreductive chemotherapeutic effect for the substantial suppression of solid tumor growth.	Oxygen	167-173	hydroxyacid oxidase 1	Homo sapiens	98-101
31381576-4	2019	Here, we report that, in the mutant for Trachealess (Trh), the Drosophila homolog for NPAS1 and NPAS3, smaller synaptic boutons form clusters named satellite boutons appear at larval neuromuscular junctions (NMJs), which is induced by the reduction of internal oxygen levels due to defective tracheal branches.	Oxygen	261-267	trachealess	Drosophila melanogaster	40-51
31381576-4	2019	Here, we report that, in the mutant for Trachealess (Trh), the Drosophila homolog for NPAS1 and NPAS3, smaller synaptic boutons form clusters named satellite boutons appear at larval neuromuscular junctions (NMJs), which is induced by the reduction of internal oxygen levels due to defective tracheal branches.	Oxygen	261-267	trachealess	Drosophila melanogaster	53-56
31339270-15	2019	CONCLUSIONS: The modified Tal score shows an adequate predictive validity, but a poor validity when correlated to oxygen saturation, and a weak inter-observer reliability.	Oxygen	114-120	transaldolase 1	Homo sapiens	26-29
30355069-8	2019	In addition, Rpd3 and Hda1 may regulate the responsiveness to oxygen in isoamyl acetate production.	Oxygen	62-68	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	22-26
31167908-7	2019	Taken together, our findings suggest that hHB is a pleiotropic regulator of RIG-I/MDA5-mediated antiviral responses and further highlight the importance of the intercellular microenvironment, including the redox state, in regulating antiviral innate immune responses.IMPORTANCE Hemoglobin, the most important oxygen-carrying protein, is involved in the regulation of innate immune responses.	Oxygen	309-315	DExD/H-box helicase 58	Homo sapiens	76-81
31257865-10	2019	We determined the P50 for oxygen to be 0.5 Torr for cytoglobin 1 and 4.4 Torr for cytoglobin 2 at 25  C. Thus, even at low oxygen tensions, the reduced cytoglobins may exist in a predominant oxygen-bound form.	Oxygen	26-32	cytoglobin 2	Danio rerio	82-94
31346464-2	2019	The essential mitochondrial import protein coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) controls respiratory chain complex activity and oxygen consumption, and regulates the growth of tumours in vivo.	Oxygen	164-170	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	43-106
31346464-2	2019	The essential mitochondrial import protein coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) controls respiratory chain complex activity and oxygen consumption, and regulates the growth of tumours in vivo.	Oxygen	164-170	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	108-114
31241322-7	2019	Mercury distribution analyses indicated that 500 mg/m3 SO2, 300 mg/m3 NO, and 6% O2 favored KCl retaining Hg2+.	Oxygen	56-58	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	106-109
31179709-4	2019	Under hypoxia environment, we observed that MnO2 could react with endogenous H2O2 to produce O2 for enhancing the catalytic efficiency of GOx for starvation therapy.	Oxygen	46-48	hydroxyacid oxidase 1	Homo sapiens	138-141
31179709-6	2019	The biochemical reaction cycle, consisting of MnO2, O2, GOx, and H+, was triggered by the tumor microenvironment and accelerated each other so as to achieve self-supplied H+ and accelerate O2 generation, enhancing the starvation therapy, alleviating tumor hypoxia and accelerating the reactive oxygen species generation in photodynamic therapy.	Oxygen	48-50	hydroxyacid oxidase 1	Homo sapiens	56-59
31179709-6	2019	The biochemical reaction cycle, consisting of MnO2, O2, GOx, and H+, was triggered by the tumor microenvironment and accelerated each other so as to achieve self-supplied H+ and accelerate O2 generation, enhancing the starvation therapy, alleviating tumor hypoxia and accelerating the reactive oxygen species generation in photodynamic therapy.	Oxygen	294-300	hydroxyacid oxidase 1	Homo sapiens	56-59
31323920-7	2019	Performing the rescue experiment by lentiviral overexpression of TSPO in knockout cells, increased oxygen consumption and restored respiratory function.	Oxygen	99-105	translocator protein	Homo sapiens	65-69
31288390-4	2019	TSPO appears to be involved in the generation of reactive oxygen species, proposed to represent the link between TSPO activation and VDAC, thus playing a role in apoptotic cell death.	Oxygen	58-64	translocator protein	Homo sapiens	0-4
31288390-4	2019	TSPO appears to be involved in the generation of reactive oxygen species, proposed to represent the link between TSPO activation and VDAC, thus playing a role in apoptotic cell death.	Oxygen	58-64	translocator protein	Homo sapiens	113-117
31026444-5	2019	In this study, we investigated the expressional level of PLVAP mRNA in VEGF-treated endothelial cells and the retinas of 2 animal models: streptozotocin-induced diabetic Brown Norway rats and Sprague-Dawley rats with oxygen-induced retinopathy.	Oxygen	217-223	plasmalemma vesicle associated protein	Rattus norvegicus	57-62
31264974-4	2019	Here, we identified a regulatory axis whereby the oxygen-sensing transcription factor HIF-1alpha orchestrated epithelial barrier integrity, selectively controlling tight junction CLDN1 (claudin-1).	Oxygen	50-56	claudin 1	Homo sapiens	179-184
31264974-4	2019	Here, we identified a regulatory axis whereby the oxygen-sensing transcription factor HIF-1alpha orchestrated epithelial barrier integrity, selectively controlling tight junction CLDN1 (claudin-1).	Oxygen	50-56	claudin 1	Homo sapiens	186-195
31096070-12	2019	Activated PMNs increased miR-223-3p export to HDL and the production of reactive oxygen species and activated protein kinase C. Blocking HDL binding to SR-BI increased miR-223-3p export to HDL in both PMNs and HMDMs, but did not affect mature and primary miR-223-3p levels.	Oxygen	81-87	scavenger receptor class B member 1	Homo sapiens	152-157
30928679-7	2019	Reducing the level of mtIF2 by shRNA is associated with ~15-20% lower content of OXPHOS complex I and IV, ~30% lower optical redox ratio, ~40% oxygen reserve capacity, and ~20% less cell survival following hypoxia.	Oxygen	143-149	mitochondrial translational initiation factor 2	Mus musculus	22-27
31117578-2	2019	It is based on the reaction between readily available 2-(3-hydroxy-1-yn-1-yl)phenols, CO, and oxygen carried out in the presence of catalytic amounts of PdI2 (1 mol %) in conjunction with KI (20 mol %) and 2 equiv of diisopropylethylamine at 80  C for 24 h under 30 atm of a 1:4 mixture of CO-air.	Oxygen	94-100	peptidyl arginine deiminase 2	Homo sapiens	153-157
30938056-0	2019	Tendinosis develops from age- and oxygen tension-dependent modulation of Rac1 activity.	Oxygen	34-40	Rac family small GTPase 1	Homo sapiens	73-77
30317637-0	2019	Brain-derived neurotrophic factor alleviates the oxidative stress induced by oxygen and glucose deprivation in an ex vivo brain slice model.	Oxygen	77-83	brain-derived neurotrophic factor	Rattus norvegicus	0-33
30927046-5	2019	Moreover, Col6a1-/- myoblasts show decreased glucose uptake and mitochondria with depolarized membrane potential and impaired functionality, as supported by decreased oxygen consumption.	Oxygen	167-173	collagen, type VI, alpha 1	Mus musculus	10-16
30924607-8	2019	METHODS: We developed a population PK model based on the principles of target-mediated drug disposition modeling, using data on total rFVIII and VWF plasma concentrations, and the rFVIII:VWF complex luminescent oxygen channeling immunoassay signal in hemophilia A rats following intravenous administration of rFVIII (17.5, 100, 1000, and 5000 IU kg-1 ).	Oxygen	211-217	von Willebrand factor	Rattus norvegicus	187-190
31022673-4	2019	In contrast, MEFs cultured at physiologically relevant conditions of 5% O2 exhibited a transient induction of Nrf2 Phase II target genes and stress-protective enzymes (the Lon protease and OXR1) following H2O2 treatment.	Oxygen	72-74	oxidation resistance 1	Mus musculus	189-193
31031004-3	2019	Here we report that when grown in 1% ambient O2, FXN null yeast, human cells, and nematodes are fully viable.	Oxygen	45-47	frataxin	Mus musculus	49-52
31031004-7	2019	Our work identifies oxygen as a key environmental variable in the pathogenesis associated with FXN depletion, with important mechanistic and therapeutic implications.	Oxygen	20-26	frataxin	Mus musculus	95-98
31075857-9	2019	FGF23 was also independently associated with frequent exacerbations (OR 1.02; 95%CI 1.004-1.04; p = 0.017), after adjusting for age, lung function, smoking, and oxygen use.	Oxygen	161-167	fibroblast growth factor 23	Homo sapiens	0-5
31009214-1	2019	The reaction of [Ni(COD)2] (COD; cyclooctadiene) in THF with the NNN-pincer ligand bis(imino)pyridyl (L1) reveals a susceptibility to oxidation in an inert atmosphere ([O2] level &lt;0.5 ppm), resulting in a transient Ni:dioxygen adduct.	Oxygen	221-229	COD2	Homo sapiens	20-25
30870640-5	2019	3-fold compared with that of the plain electrode, while an in situ deoxygenation process, based on GOx-glucose enzyme reaction, depletes dissolved oxygen.	Oxygen	69-75	hydroxyacid oxidase 1	Homo sapiens	99-102
30921734-3	2019	Here, we utilize GOx-CPO as integrated tandem enzymes to in situ generate singlet oxygen, which could be not only for oxidative cross-linking of injectable hydrogel carriers but also for continuous tumor treatment by adjustable bioconversion of blood oxygen, glucose, and chloride ion.	Oxygen	82-88	hydroxyacid oxidase 1	Homo sapiens	17-20
30921734-3	2019	Here, we utilize GOx-CPO as integrated tandem enzymes to in situ generate singlet oxygen, which could be not only for oxidative cross-linking of injectable hydrogel carriers but also for continuous tumor treatment by adjustable bioconversion of blood oxygen, glucose, and chloride ion.	Oxygen	82-88	carboxypeptidase O	Homo sapiens	21-24
30964974-5	2019	The obtained nanosystem (HA-CAT@aCe6) could target overly expressed CD44 receptors on cancer cells, supplying oxygen by converting endogenous hydrogen peroxide (H2O2) to oxygen, and improving PDT efficacy upon light irradiation.	Oxygen	110-116	CD44 molecule (Indian blood group)	Homo sapiens	68-72
30964974-5	2019	The obtained nanosystem (HA-CAT@aCe6) could target overly expressed CD44 receptors on cancer cells, supplying oxygen by converting endogenous hydrogen peroxide (H2O2) to oxygen, and improving PDT efficacy upon light irradiation.	Oxygen	170-176	CD44 molecule (Indian blood group)	Homo sapiens	68-72
30996297-8	2019	Cancer organoids from PKM2DeltaLgr5-Tx mice exhibited increased mitochondrial oxygen consumption and a shift of metabolites involved in energy metabolism.	Oxygen	78-84	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	22-35
31031639-3	2019	Aerobic training interventions and improvements in peak oxygen uptake (VO2peak) have been associated with increases in the peripheral concentration of brain-derived neurotrophic factor (BDNF) and better cognitive performances.	Oxygen	56-62	brain derived neurotrophic factor	Homo sapiens	151-184
31031639-3	2019	Aerobic training interventions and improvements in peak oxygen uptake (VO2peak) have been associated with increases in the peripheral concentration of brain-derived neurotrophic factor (BDNF) and better cognitive performances.	Oxygen	56-62	brain derived neurotrophic factor	Homo sapiens	186-190
30855953-0	2019	Spin, Valence, and Structural Isomerism in the S3 State of the Oxygen-Evolving Complex of Photosystem II as a Manifestation of Multimetallic Cooperativity.	Oxygen	63-69	spindlin 1	Homo sapiens	0-4
30680696-5	2019	Calgranulin B showed several significant correlations with functional parameters (oxygen demand at rest, 6-min walking test (6MWT), and PFTs); KL-6 was correlated with oxygen demand at rest and during 6MWT.	Oxygen	82-88	S100 calcium binding protein A9	Homo sapiens	0-13
30726964-10	2019	Expression of a number of RAS mRNAs (ATP6AP2, AGT, ACE and AGTR1) were increased in either, or both, 1 and 5% oxygen compared with 20% oxygen.	Oxygen	110-116	ATPase H+ transporting accessory protein 2	Homo sapiens	37-44
30726964-10	2019	Expression of a number of RAS mRNAs (ATP6AP2, AGT, ACE and AGTR1) were increased in either, or both, 1 and 5% oxygen compared with 20% oxygen.	Oxygen	135-141	ATPase H+ transporting accessory protein 2	Homo sapiens	37-44
30793878-3	2019	Co2P@CNF shows high oxygen reduction reaction and oxygen evolution reaction performance owing to the synergistic effect of Co2P nanocrystals and the neighboring CoNx moieties, which have the optimum binding strength of reactants and facilitate the mass transfer.	Oxygen	20-26	NPHS1 adhesion molecule, nephrin	Homo sapiens	5-8
30793878-3	2019	Co2P@CNF shows high oxygen reduction reaction and oxygen evolution reaction performance owing to the synergistic effect of Co2P nanocrystals and the neighboring CoNx moieties, which have the optimum binding strength of reactants and facilitate the mass transfer.	Oxygen	50-56	NPHS1 adhesion molecule, nephrin	Homo sapiens	5-8
30836629-8	2019	The full trajectory of hTKFC:2DHA:2ATP was searched for in-line orientations and short distances of DHA hydroxymethyl oxygens to ATP gamma-phosphorus.	Oxygen	118-125	triokinase and FMN cyclase	Homo sapiens	23-28
30666520-0	2019	Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3epsilon/NF-kappaB/MMP9 Signal Transduction Pathway.	Oxygen	39-45	myosin, heavy polypeptide 9, non-muscle	Mus musculus	0-10
30293223-3	2019	This is an unusual and potentially fatal condition in which hemoglobin is oxidized to methemoglobin (MHb), reducing the amount of oxygen that is released from hemoglobin, similar to carbon monoxide poisoning.	Oxygen	130-136	hemoglobin subunit gamma 2	Homo sapiens	86-99
30293223-3	2019	This is an unusual and potentially fatal condition in which hemoglobin is oxidized to methemoglobin (MHb), reducing the amount of oxygen that is released from hemoglobin, similar to carbon monoxide poisoning.	Oxygen	130-136	hemoglobin subunit gamma 2	Homo sapiens	101-104
30664207-0	2019	beta-elemene inhibits oxygen-induced retinal neovascularization via promoting miR-27a and reducing VEGF expression.	Oxygen	22-28	microRNA 27a	Mus musculus	78-85
30664207-0	2019	beta-elemene inhibits oxygen-induced retinal neovascularization via promoting miR-27a and reducing VEGF expression.	Oxygen	22-28	vascular endothelial growth factor A	Mus musculus	99-103
30575339-9	2019	RESULTS: Serum brain-derived neurotrophic factor (BDNF) concentration at birth had significant negative correlation with later diagnosis of BPD (P = 0.011) and with duration of invasive ventilation and oxygen supplementation (P = 0.009 and 0.015, respectively).	Oxygen	202-208	brain derived neurotrophic factor	Homo sapiens	15-48
30575339-9	2019	RESULTS: Serum brain-derived neurotrophic factor (BDNF) concentration at birth had significant negative correlation with later diagnosis of BPD (P = 0.011) and with duration of invasive ventilation and oxygen supplementation (P = 0.009 and 0.015, respectively).	Oxygen	202-208	brain derived neurotrophic factor	Homo sapiens	50-54
30736871-9	2019	All three serum markers of AKI (cystatin C, NGAL, and IL-18) studied were positively correlated with OSA severity, and two (cystatin C and IL-18) were positively correlated with the frequency of oxygen desaturation during sleep.	Oxygen	195-201	interleukin 18	Homo sapiens	139-144
30510139-8	2019	They suggest that when photosynthetic electron carriers are highly reduced, a chloroplast-mitochondria coupling allows safe dissipation of photosynthetically derived electrons via the reduction of O2 through AOX (especially AOX1)-dependent mitochondrial respiration.	Oxygen	197-199	uncharacterized protein	Chlamydomonas reinhardtii	224-228
30774348-0	2019	Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3beta/beta-catenin pathway.	Oxygen	11-17	catenin (cadherin associated protein), beta 1	Mus musculus	107-119
30679577-1	2019	Herein we report a strategy of rapid oxidation of the hole transport layer (HTL) in perovskite solar cells by using oxygen/argon mixture plasma.	Oxygen	116-122	Leucine transport, high	Homo sapiens	76-79
30679577-3	2019	Compared to the conventional process of overnight oxidation, only ~10 s of oxygen/argon mixture plasma treatment is enough for the solar cell devices with FTO/ETL/perovskite/HTL/Au structure demonstrating a high power conversion efficiency.	Oxygen	75-81	Leucine transport, high	Homo sapiens	174-177
30679577-4	2019	It is found that the high concentration of atomic oxygen generated in plasma oxidizing the HTL improves the conductivity and mobility, and therefore the process time is considerably shortened.	Oxygen	50-56	Leucine transport, high	Homo sapiens	91-94
30525435-3	2019	Therefore, P25 could efficiently photooxidize NO(g) + O2(g) into NO2; however, it failed to store photogenerated NO2 and released toxic NO2(g) to the atmosphere.	Oxygen	54-56	tubulin polymerization promoting protein	Homo sapiens	11-14
30601584-22	2019	Of five studies that considered peripheral oxygen saturation levels, only two reported that use of chest physiotherapy (CPAP and conventional chest physiotherapy) showed a greater improvement in peripheral oxygen saturation levels.	Oxygen	206-212	centromere protein J	Homo sapiens	120-124
30651823-0	2019	Therapeutic effect of combined hyperbaric oxygen and radiation therapy for single brain metastasis and its influence on osteopontin and MMP-9.	Oxygen	42-48	matrix metallopeptidase 9	Homo sapiens	136-141
31172469-3	2019	In a flavin-dependent fashion, cytochrome b558 shuttles electrons from cytoplasmic NADPH across membranes to molecular oxygen and thereby generates superoxide anion.	Oxygen	119-125	mitochondrially encoded cytochrome b	Homo sapiens	31-43
31172485-2	2019	NOX2 carries all redox stations through which electrons flow from NADPH to molecular oxygen, to generate the primary ROS, superoxide.	Oxygen	85-91	cytochrome b-245 beta chain	Homo sapiens	0-4
29938378-10	2019	Immunohistostaining for p47phox, which is an important indicator of the oxygen-dependent phagocytosis, showed a decrease in its levels when cells were treated for only 15 min with 100 microM H2O2, whereas at 24-h post-treatment there was no change in the p47phox levels.	Oxygen	72-78	neutrophil cytosolic factor 1	Homo sapiens	24-31
29938378-10	2019	Immunohistostaining for p47phox, which is an important indicator of the oxygen-dependent phagocytosis, showed a decrease in its levels when cells were treated for only 15 min with 100 microM H2O2, whereas at 24-h post-treatment there was no change in the p47phox levels.	Oxygen	72-78	neutrophil cytosolic factor 1	Homo sapiens	255-262
29687347-3	2019	Using highly differentiated rat PC12 cells exposed to either severe hypoxia (0.5-1% O2) for 24-48 h or varying concentrations of MPP+, we found that both hypoxic and MPP+ stress reduced the level of PINK1 expression, while incubation with the specific DOR agonist UFP-512 reversed this reduction and protected the cells from hypoxia and/or MPP+-induced injury.	Oxygen	84-86	PTEN induced kinase 1	Rattus norvegicus	199-204
31262220-5	2019	Remarkably, upon treatment with the flg22, elf18 and pep1 PAMP/DAMPs, BSK5-overexpressing plants displayed higher levels of immune responses, including production of reactive oxygen species, callose deposition at the cell wall, and PATHOGENESIS-RELATED1 (PR1) gene expression.	Oxygen	175-181	precursor of peptide 1	Arabidopsis thaliana	53-57
30577438-9	2018	SpD treatment increased ATP production and the oxygen consumption rate in D-galactose-treated AC16 cells.	Oxygen	47-53	surfactant protein D	Homo sapiens	0-3
30651902-10	2018	Moreover, intrathecal administration of 20 mug/mL oxygen/ozone reversed the increased levels of spinal PDE2A and NF-kappaB/p65 mRNA and protein expressions in rats with chronic radiculitis.	Oxygen	50-56	phosphodiesterase 2A	Rattus norvegicus	103-108
30651902-11	2018	Conclusion: Intrathecal administration of low-concentration oxygen/ozone alleviated mechanical allodynia and attenuated radiculitis, likely by a PDE2A-cGMP/cAMP-NF-kappaB/p65 signaling pathway in chronic radiculitis rats.	Oxygen	60-66	phosphodiesterase 2A	Rattus norvegicus	145-150
30073566-0	2018	Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-kappaB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes.	Oxygen	11-17	C-X-C motif chemokine ligand 1	Homo sapiens	113-118
29504250-16	2018	CONCLUSION: The hyperbaric oxygen can up-regulate bax/bcl-2 value, increase the cell apoptosis rate, and inhibit the early hypertrophic scar in rabbit ears.	Oxygen	27-33	BCL-2	Oryctolagus cuniculus	54-59
30381478-6	2018	We now report that exposure of primary murine AEC to hypoxia (1% oxygen) for 24 h results in significant suppression of key innate immune molecules, including GM-CSF, CCL2, and IL-6.	Oxygen	65-71	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	159-165
30381478-6	2018	We now report that exposure of primary murine AEC to hypoxia (1% oxygen) for 24 h results in significant suppression of key innate immune molecules, including GM-CSF, CCL2, and IL-6.	Oxygen	65-71	chemokine (C-C motif) ligand 2	Mus musculus	167-171
30381478-10	2018	In mice exposed to hypoxia in vivo (12% oxygen for 2 d), lung GM-CSF protein expression was reduced.	Oxygen	40-46	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	62-68
30177551-5	2018	When cultured in pyruvate-containing media, POLG exonuclease-deficient MEFs showed decreased oxygen consumption compared to controls.	Oxygen	93-99	polymerase (DNA directed), gamma	Mus musculus	44-48
30443557-8	2018	SCF correlated to pulmonary vascular resistance (r=-0.66, p&lt;0.0001), cardiac index (r=0.66, p&lt;0.0001), venous oxygen saturation (r=0.47, p&lt;0.0008), mean right atrial pressure (r=-0.44, p&lt;0.002) and N-terminal pro-brain natriuretic protein (r=-0.39, p&lt;0.006).	Oxygen	116-122	KIT ligand	Homo sapiens	0-3
30628235-4	2018	A2O waste sludge showed better biodegradability than A2O-MBR waste sludge did, with 16.4% higher organic matter content (66.4% vs. 50.0%), soluble chemical oxygen demand (COD) (1.24 fold), soluble protein (2.02 fold), and polysaccharides (4.84 fold).	Oxygen	156-162	translocator protein	Homo sapiens	57-60
30172109-1	2018	A catalytic and metal free sulfoxidation of O-2-(2-propylthiol)benzyl (OPTB) glycosides to O-2-(2-propylsulfinyl)benzyl (OPSB) glycosides has been developed by introducing NOBF4 as catalyst, oxygen as terminal oxidant and TBAB as additive.	Oxygen	191-197	immunoglobulin kappa variable 1D-39	Homo sapiens	44-47
30172109-1	2018	A catalytic and metal free sulfoxidation of O-2-(2-propylthiol)benzyl (OPTB) glycosides to O-2-(2-propylsulfinyl)benzyl (OPSB) glycosides has been developed by introducing NOBF4 as catalyst, oxygen as terminal oxidant and TBAB as additive.	Oxygen	191-197	immunoglobulin kappa variable 1D-39	Homo sapiens	91-94
29967109-8	2018	This related model is the first from a SDHB-mutated human tumor that can be experimentally manipulated to study mechanisms of oxygen effects and novel treatment strategies.	Oxygen	126-132	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	39-43
30144565-1	2018	Ceruloplasmin is an ancient multicopper oxidase evolved to insure a safe handling of oxygen in some metabolic pathways of vertebrates.	Oxygen	85-91	ceruloplasmin	Danio rerio	0-13
30539720-13	2018	CONCLUSIONS: Oxygen may regulate AQP4 expression in human placenta, possibly through HIF-1alpha.	Oxygen	13-19	aquaporin 4	Homo sapiens	33-37
30277747-5	2018	Subsequently, LOX oxidizes the lactate to pyruvate inside the carrier, accompanied by internal lowering of oxygen partial pressure.	Oxygen	107-113	lysyl oxidase	Homo sapiens	14-17
30328811-5	2018	Our data suggest that the pleiotropic effects of glb-5 and npr-1 are a consequence of changes to O2 -sensing neurons that regulate both aerotaxis and energy homeostasis.	Oxygen	97-99	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	59-64
30402039-9	2018	Expression levels for Bcl-xL, caspase-9, receptor for advanced glycation end products (RAGE) and brain-derived neurotrophic factor (BDNF) were significantly different in quantification of band intensity between the rats that inhaled O2 and sevoflurane in Abeta-treated groups (all P &lt; 0.05).	Oxygen	233-235	brain-derived neurotrophic factor	Rattus norvegicus	97-130
30402039-9	2018	Expression levels for Bcl-xL, caspase-9, receptor for advanced glycation end products (RAGE) and brain-derived neurotrophic factor (BDNF) were significantly different in quantification of band intensity between the rats that inhaled O2 and sevoflurane in Abeta-treated groups (all P &lt; 0.05).	Oxygen	233-235	brain-derived neurotrophic factor	Rattus norvegicus	132-136
30216060-6	2018	The ether moiety, the oxygen of which originates from the P450-catalyzed hydroxylation at C-11, is formed via cyclization of the diol intermediate.	Oxygen	22-28	aldo-keto reductase family 1 member C4	Homo sapiens	90-94
30092229-1	2018	Myoglobin, besides its role in oxygen turnover, has gained recognition as a potential regulator of lipid metabolism.	Oxygen	31-37	myoglobin	Mus musculus	0-9
29966978-6	2018	Silencing of PINK1 also resulted in oxygen species (ROS) overproduction and decreased mitochondrial membrane potential.	Oxygen	36-42	PTEN induced kinase 1	Homo sapiens	13-18
30213210-3	2018	We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1.	Oxygen	94-100	heme oxygenase 1	Rattus norvegicus	69-74
30213210-3	2018	We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1.	Oxygen	94-100	heme oxygenase 1	Rattus norvegicus	182-187
30244258-7	2018	RESULTS Following forced MV-O2, increased levels of IL-33 in whole mouse lungs were associated with impaired alveolar growth and with changes consistent with BPD, including reduced numbers of enlarged alveoli, increased apoptosis, and increased expression of IL-1beta, CXCL-1, and MCP-1.	Oxygen	28-30	interleukin 33	Mus musculus	52-57
30244258-8	2018	IL-33 inhibition improved alveolar development in hyperoxia-impaired lungs and suppressed IL-1beta and MCP-1 expression and was associated with increased transforming growth factor-beta (TGF-beta) signaling, reduced pulmonary NF-kappaB activity and decreased expression of the TGF-beta inhibitor SMAD-7 in forced MV-O2 exposed mouse pups.	Oxygen	316-318	interleukin 33	Mus musculus	0-5
30100055-5	2018	Heterozygous R155C VCP knock-in mice showed decreased plasma lactate, serum albumin and total protein concentrations, platelet numbers, and liver to body weight ratios, and increased oxygen consumption and CD8+/Ly6C + T-cell fractions, but none of the typical human IBMPFD or ALS pathologies.	Oxygen	183-189	valosin containing protein	Mus musculus	19-22
29937372-4	2018	AOX substantially increases the rate of NADH oxidation by O2 without affecting the membrane integrity, the supercomplexes, or NADH-linked oxidative phosphorylation.	Oxygen	58-60	acyl-CoA oxidase 1	Homo sapiens	0-3
29633336-6	2018	The results showed that the highest production of prIDS was obtained at oxygen-limited conditions using a codon-optimized IDS cDNA.	Oxygen	72-78	iduronate 2-sulfatase	Homo sapiens	52-55
29745803-4	2018	Blocking of the Bohr effect in this model system results in a dramatic increase in the oxygen affinity, as expressed by the oxygen partial pressure at half saturation, the P50.	Oxygen	87-93	activating signal cointegrator 1 complex subunit 1	Homo sapiens	172-175
29745803-4	2018	Blocking of the Bohr effect in this model system results in a dramatic increase in the oxygen affinity, as expressed by the oxygen partial pressure at half saturation, the P50.	Oxygen	124-130	activating signal cointegrator 1 complex subunit 1	Homo sapiens	172-175
29680477-5	2018	We now find that knockdown of TEAD1 decreases the expression of PGC1alpha and suppresses mitochondrial biogenesis, glycolysis, and oxygen consumption in ECs.	Oxygen	131-137	TEA domain family member 1	Mus musculus	30-35
29680477-6	2018	A YAP1 mutant construct, YAP1S127A, which stimulates binding of YAP1 to TEAD1, upregulates the expression of PGC1alpha, induces mitochondrial biogenesis, and increases oxygen consumption and glycolytic flux in ECs; in contrast, YAP1S94A, which fails to bind to TEAD1, attenuates these effects.	Oxygen	168-174	TEA domain family member 1	Mus musculus	72-77
29862666-10	2018	Lower nadir oxygen saturation was associated with higher levels of tonsil TNF-alpha (P &lt; 0.001) and IL-10 (P &lt; 0.05).	Oxygen	12-18	interleukin 10	Homo sapiens	103-108
30061407-5	2018	Intriguingly, DPYSL4 overexpression in cancer cells and preadipocytes up-regulated ATP production and oxygen consumption, while DPYSL4 knockdown using siRNA or CRISPR/Cas9 down-regulated energy production.	Oxygen	102-108	dihydropyrimidinase like 4	Homo sapiens	14-20
29738858-1	2018	OBJECTIVE: Neuroglobin (Ngb) has a high affinity for oxygen and helps prevent hypoxic-ischemic brain damage.	Oxygen	53-59	neuroglobin	Homo sapiens	11-22
29738858-1	2018	OBJECTIVE: Neuroglobin (Ngb) has a high affinity for oxygen and helps prevent hypoxic-ischemic brain damage.	Oxygen	53-59	neuroglobin	Homo sapiens	24-27
29885280-3	2018	Reduced species of Cl2 NQ and ascorbate are oxidized by photooxidized PS I primary donor P700+ and/or by molecular oxygen.	Oxygen	115-121	endogenous retrovirus group W member 5	Homo sapiens	19-22
29476855-5	2018	The hydroxyl groups on AF1 nanotubes not only acted as reducing agents but also were able to stabilize AuNPs by the strong interaction between the surface Au atoms of AuNPs and oxygen atoms of AF1 nanotubes.	Oxygen	177-183	interferon gamma receptor 2	Homo sapiens	23-26
29476855-5	2018	The hydroxyl groups on AF1 nanotubes not only acted as reducing agents but also were able to stabilize AuNPs by the strong interaction between the surface Au atoms of AuNPs and oxygen atoms of AF1 nanotubes.	Oxygen	177-183	interferon gamma receptor 2	Homo sapiens	193-196
29997451-6	2018	Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context.	Oxygen	9-15	centromere protein J	Homo sapiens	95-99
29621550-0	2018	RETRACTED: Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway.	Oxygen	55-61	vascular endothelial growth factor A	Mus musculus	109-113
29791845-4	2018	ENT3 deficiency leads to an enlarged and disturbed lysosomal compartment, resulting in accumulation of surplus mitochondria, elevation of intracellular reactive oxygen species, and DNA damage in T cells.	Oxygen	161-167	solute carrier family 29 member 3	Homo sapiens	0-4
29760417-1	2018	Expression of hypoxia-inducible factors (HIFs) and N-myc downstream-regulated gene 3 (NDRG3) are oxygen-dependently regulated by prolyl hydroxylase domain (PHD) enzymes.	Oxygen	97-103	NDRG family member 3	Homo sapiens	51-84
29760417-1	2018	Expression of hypoxia-inducible factors (HIFs) and N-myc downstream-regulated gene 3 (NDRG3) are oxygen-dependently regulated by prolyl hydroxylase domain (PHD) enzymes.	Oxygen	97-103	NDRG family member 3	Homo sapiens	86-91
29667813-10	2018	1H NMR studies and DFT calculations indicate that Hg2+ ions coordinate to oxygen-donor atoms from both the chromophore and macrocycle, leading to sensitive mercury detection.	Oxygen	74-80	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	50-53
29443450-2	2018	Lys241 of the KDM4 subfamily is proposed to be important in oxygen binding by KDM4A.	Oxygen	60-66	lysine demethylase 4A	Homo sapiens	78-83
29629754-4	2018	The saturation magnetization value reaches a maximum of 0.2975 emu g-1 at 300 K when the reaction time is 12 h, indicating that the Curie temperature ( TC) is higher than 300 K. Combined with first-principles calculation, the coupling between B 2p orbital, N 2p orbital, and O 2p orbital in the conduction bands is the main origin of room-temperature ferromagnetism and also proves that the magnetic moment changes according the oxygen-doping content change.	Oxygen	429-435	immunoglobulin kappa variable 5-2	Homo sapiens	243-247
29501817-8	2018	STATEMENT OF SIGNIFICANCE: Vascular endothelial growth factor (VEGF) is crucial for facilitating angiogenesis to supply oxygen and nutrient during wound healing and tissue regeneration.	Oxygen	120-126	vascular endothelial growth factor A	Mus musculus	27-61
29501817-8	2018	STATEMENT OF SIGNIFICANCE: Vascular endothelial growth factor (VEGF) is crucial for facilitating angiogenesis to supply oxygen and nutrient during wound healing and tissue regeneration.	Oxygen	120-126	vascular endothelial growth factor A	Mus musculus	63-67
29317435-7	2018	MKP1-MKO mice exhibited increased whole-body energy expenditure that was associated with elevated levels of myofiber-associated mitochondrial oxygen consumption.	Oxygen	142-148	dual specificity phosphatase 1	Mus musculus	0-4
29808689-11	2018	We have demonstrated a reduced sensitivity of MT-3 transfected cells to CDDP (24h IC50 of 7.48 +- 0.97 and 19.81 +- 1.2 mug/ml), a higher number of colonies after incubation with CDDP, reduced caspase 3 after incubation with CDDP and lower free oxygen radicals after induction of CDDP.	Oxygen	245-251	metallothionein 3	Homo sapiens	46-50
29534204-15	2018	The expression level of hCGbeta was equivalent in both oxygen conditions, indicating that there was no difference in trophoblast differentiation.	Oxygen	55-61	chorionic gonadotropin subunit beta 3	Homo sapiens	24-31
29414416-3	2018	This is largely due to the suppression of BCR/Abl protein, driven by the reduction of energy supply due to oxygen or glucose shortage, in stem cell niches of bone marrow.	Oxygen	107-113	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	42-49
29510031-4	2018	The nanocarriers are designed to enhance the efficacy of the hypoxia-suppressed GOx-mediated starvation therapy by catalyzing the decomposition of intratumoral hydroperoxide into oxygen with PHPBNs, and the enhanced glucose depletion by the two complementary biocatalysts may consequently suppress the expression of heat shock proteins (HSPs) after photothermal treatment to reduce their resistance to the PHPBN-mediated low-temperature photothermal therapies.	Oxygen	179-185	hydroxyacid oxidase 1	Homo sapiens	80-83
29581565-8	2018	Here, we show that ImpL3 coding for Lactate Dehydrogenase in Drosophila, is regulated by ARE-mediated decay (AMD) with dTIS11 contributing to ImpL3 rapid down-regulation upon return to normal oxygen levels after hypoxia.	Oxygen	192-198	Lactate dehydrogenase	Drosophila melanogaster	19-24
29581565-8	2018	Here, we show that ImpL3 coding for Lactate Dehydrogenase in Drosophila, is regulated by ARE-mediated decay (AMD) with dTIS11 contributing to ImpL3 rapid down-regulation upon return to normal oxygen levels after hypoxia.	Oxygen	192-198	Lactate dehydrogenase	Drosophila melanogaster	36-57
29581565-8	2018	Here, we show that ImpL3 coding for Lactate Dehydrogenase in Drosophila, is regulated by ARE-mediated decay (AMD) with dTIS11 contributing to ImpL3 rapid down-regulation upon return to normal oxygen levels after hypoxia.	Oxygen	192-198	Lactate dehydrogenase	Drosophila melanogaster	142-147
29570992-1	2018	Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor (VEGF) upon ischemia or exercise.	Oxygen	104-110	vascular endothelial growth factor A	Mus musculus	148-182
29570992-1	2018	Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor (VEGF) upon ischemia or exercise.	Oxygen	104-110	vascular endothelial growth factor A	Mus musculus	184-188
29463086-5	2018	In the presence of oxygen and visible light, NiO photocathodes sensitized with commercially available porphyrin, coumarin, and ruthenium dyes exhibit large photocurrents (up to 400 muA/cm2) near the thermodynamic potential for O2/H2O2 in near-neutral water.	Oxygen	19-25	immunoglobulin kappa variable 1D-39	Homo sapiens	227-234
29269703-6	2018	In bovine granulosa cells cultured for 6 hr under hypoxia (3% O2) and normoxia (20% O2), BNIP3 mRNA expression was higher under hypoxia.	Oxygen	62-64	BCL2 interacting protein 3	Bos taurus	89-94
29269703-6	2018	In bovine granulosa cells cultured for 6 hr under hypoxia (3% O2) and normoxia (20% O2), BNIP3 mRNA expression was higher under hypoxia.	Oxygen	84-86	BCL2 interacting protein 3	Bos taurus	89-94
29498652-3	2018	Results show that the alkali treatment leads to the increase of surface area and surface oxygen-containing groups of Ti3C2X2, thereby facilitating the dispersion and stabilization of Pd species on the surface of alk-Ti3C2X2.	Oxygen	89-95	ALK receptor tyrosine kinase	Homo sapiens	22-25
29411431-3	2018	The pi-conjugated polymer PBDB-T is found to trigger a heterogeneous nucleation over the perovskite precursor film and passivate the trap states of the mixed perovskite film through the formation of Lewis adducts between lead and oxygen atom in PBDB-T.	Oxygen	230-236	TRAP	Homo sapiens	133-137
29439904-1	2018	Replacement of the piperidine ring in the lead benzenesulfonamide Nav1.7 inhibitor 1 with a weakly basic morpholine core resulted in a significant reduction in Nav1.7 inhibitory activity, but the activity was restored by shortening the linkage from methyleneoxy to oxygen.	Oxygen	265-271	sodium voltage-gated channel alpha subunit 9	Homo sapiens	66-72
29259012-0	2018	FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.	Oxygen	10-16	euchromatic histone lysine methyltransferase 2	Homo sapiens	46-49
29259012-2	2018	Here, we show that FIH exerts an additional role as an oxygen sensor in epigenetic control by the histone lysine methyltransferases G9a and GLP.	Oxygen	55-61	euchromatic histone lysine methyltransferase 2	Homo sapiens	132-143
29259012-8	2018	It also implies that the FIH-G9a/GLP pathway could be a potential target for inhibiting hypoxia-induced cancer metastasis.Significance: These findings deepen understanding of oxygen-dependent gene regulation and cancer metastasis in response to hypoxia.	Oxygen	175-181	euchromatic histone lysine methyltransferase 2	Homo sapiens	29-32
29091306-1	2018	This study explores the effects of apelin on retinal microglial cells in rat models of oxygen-induced retinopathy of prematurity (ROP).	Oxygen	87-93	apelin	Rattus norvegicus	35-41
29091306-11	2018	Appropriate concentration of apelin may reduce retinal microglial cells in a rat model of oxygen-induced ROP.	Oxygen	90-96	apelin	Rattus norvegicus	29-35
29269217-2	2018	Advances concerning in vivo regulation of AOX based on the oxygen-isotope fractionation technique are reviewed, and regulatory factors that merit future research are highlighted.	Oxygen	59-65	acyl-CoA oxidase 1	Homo sapiens	42-45
29416029-0	2018	Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal.	Oxygen	109-115	neuroglobin	Homo sapiens	0-11
29416029-3	2018	Here we reported that neuroglobin (Ngb), a novel oxygen-binding or sensor protein existing predominantly in neurons or brains, functions as a driving factor for axon regeneration during I/R.	Oxygen	49-55	neuroglobin	Homo sapiens	22-33
29416029-3	2018	Here we reported that neuroglobin (Ngb), a novel oxygen-binding or sensor protein existing predominantly in neurons or brains, functions as a driving factor for axon regeneration during I/R.	Oxygen	49-55	neuroglobin	Homo sapiens	35-38
29416029-8	2018	Serial truncation and point mutation of Ngb revealed that the 7-105 aa fragment of Ngb was required and the oxygen-binding site (His64) of Ngb was the major regulatory site for its p38 interaction/activation.	Oxygen	108-114	neuroglobin	Homo sapiens	40-43
29416029-8	2018	Serial truncation and point mutation of Ngb revealed that the 7-105 aa fragment of Ngb was required and the oxygen-binding site (His64) of Ngb was the major regulatory site for its p38 interaction/activation.	Oxygen	108-114	neuroglobin	Homo sapiens	83-86
29416029-8	2018	Serial truncation and point mutation of Ngb revealed that the 7-105 aa fragment of Ngb was required and the oxygen-binding site (His64) of Ngb was the major regulatory site for its p38 interaction/activation.	Oxygen	108-114	neuroglobin	Homo sapiens	83-86
28865129-8	2018	The 5% oxygen atmosphere did not influence cell proliferation, but enhanced slightly ACAN and COL2A1 gene expression.	Oxygen	7-13	aggrecan	Homo sapiens	85-89
29188989-4	2018	Our crystal structure of 5,6-dihydroxy NADPH-bound ADH/D1 combined with biochemical analyses reveal the molecular features of its halo-thermophily, its unique habitat adaptations, and its possible reaction mechanism for atypical oxygen activation.	Oxygen	229-235	ADHD1	Homo sapiens	51-57
29352221-3	2018	METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism.	Oxygen	52-58	electron transfer flavoprotein beta subunit lysine methyltransferase	Mus musculus	0-7
29352221-3	2018	METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism.	Oxygen	52-58	electron transfer flavoprotein beta subunit lysine methyltransferase	Mus musculus	123-130
29324690-0	2018	Effects of Agitation, Aeration and Temperature on Production of a Novel Glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and Scale-Up Based on Volumetric Oxygen Transfer Coefficient.	Oxygen	155-161	GTP binding protein 1	Homo sapiens	85-89
29324690-4	2018	In addition, a successful scale-up from bench-scale to pilot-scale was performed based on volumetric oxygen transfer coefficient, resulting in final GP-1 production of 3.92, 4.03, 3.82 and 4.20 mg/L in 5 L, 15 L, 70 L and 500 L fermentors, respectively.	Oxygen	101-107	GTP binding protein 1	Homo sapiens	149-153
29324690-5	2018	These results indicated that constant volumetric oxygen transfer coefficient was appropriate for the scale-up of batch fermentation of glycoprotein GP-1 by Streptomyces kanasenisi ZX01, and this scale-up strategy successfully achieved 100-fold scale-up from bench-scale to pilot-scale fermentor.	Oxygen	49-55	GTP binding protein 1	Homo sapiens	148-152
29235837-1	2018	In this study, we report a colloidal synthesis of palladium sulfides (including Pd16S7, Pd4S, and PdS) via a facile one-pot hot-solution synthetic route and their promising application as electrocatalyst for the oxygen reduction reaction (ORR).	Oxygen	212-218	solute carrier family 26 member 4	Homo sapiens	98-101
29220576-2	2018	We herein develop hybrid core-shell semiconducting nanoparticles (SPN-Ms) that can undergo O2 evolution in hypoxic solid tumor to promote photodynamic process.	Oxygen	91-93	DEAF1 transcription factor	Homo sapiens	66-69
29545920-7	2018	Hypoxia (1% O2) upregulated CD86, CD274, HLA-DR, and CD54, and downregulated CD40 and CD83 in DCs as compared to normoxia (21% O2).	Oxygen	12-14	intercellular adhesion molecule 1	Homo sapiens	53-57
29298418-0	2018	Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells.	Oxygen	45-51	neuronal PAS domain protein 4	Homo sapiens	0-29
29202474-5	2018	Moreover, ADHFE1 promoted metabolic reprogramming with increased formation of D-2HG and reactive oxygen, a reductive glutamine metabolism, and modifications of the epigenetic landscape, leading to cellular dedifferentiation, enhanced mesenchymal transition, and phenocopying alterations that occur with high D-2HG levels in cancer cells with IDH mutations.	Oxygen	97-103	alcohol dehydrogenase iron containing 1	Homo sapiens	10-16
29165030-10	2018	Importantly, transfection of the phosphomimetic Tomm22 mutant in muscle cells with ablated Csnk2b restored their oxygen consumption rate comparable to wild-type levels.	Oxygen	113-119	casein kinase 2, beta polypeptide	Mus musculus	91-97
29053141-0	2018	Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.	Oxygen	36-42	BCL2-like 11 (apoptosis facilitator)	Mus musculus	8-11
29053141-4	2018	BIM-/- cells had a higher mitochondrial oxygen consumption rate that was associated with higher mitochondrial complex IV activity.	Oxygen	40-46	BCL2-like 11 (apoptosis facilitator)	Mus musculus	0-3
29053141-5	2018	The consequences of increased oxygen consumption in BIM-/- mice were significantly lower body weights, reduced adiposity and lower hepatic lipid content.	Oxygen	30-36	BCL2-like 11 (apoptosis facilitator)	Mus musculus	52-55
28990117-0	2018	Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.	Oxygen	156-162	matrix metallopeptidase 12	Homo sapiens	14-41
28990117-7	2018	Quantification revealed a decline in MMP12 positive evCT at the end of first trimester, when oxygen levels start rising.	Oxygen	93-99	matrix metallopeptidase 12	Homo sapiens	37-42
28990117-8	2018	MMP12 promoter analysis identified potential binding sites for hypoxia-inducible factor (HIF-1) and other oxygen-sensitive transcription factors.	Oxygen	106-112	matrix metallopeptidase 12	Homo sapiens	0-5
28990117-9	2018	Moreover, MMP12 protein was increased by low oxygen in FT in vitro and by addition of a HIF-1alpha activator.	Oxygen	45-51	matrix metallopeptidase 12	Homo sapiens	10-15
28990117-11	2018	MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha.	Oxygen	36-42	matrix metallopeptidase 12	Homo sapiens	0-5
28990117-11	2018	MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha.	Oxygen	36-42	matrix metallopeptidase 12	Homo sapiens	96-101
29236166-0	2018	Correction to: Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A.	Oxygen	171-177	matrix metallopeptidase 12	Homo sapiens	29-56
29439330-3	2018	Hypoxia is known to have a notable effect on controlling the expression of proteins involved in a broad range of biological processes varying from energy metabolism, erythropoiesis, angiogenesis, neurogenesis to mitochondrial trafficking and autophagy, thus facilitating neuronal cells to endure in deprived O2.	Oxygen	308-310	immunoglobulin kappa variable 1D-39	Homo sapiens	0-7
29970668-11	2018	EGFL7 protein expression level was oxygen dependent in HCC line (P &lt; 0.05).	Oxygen	35-41	EGF like domain multiple 7	Homo sapiens	0-5
28332183-6	2018	These results collectively suggest that RORalpha functions as an important mediator of HIF-1alpha activities in regulating keratinocyte differentiation/survival and epidermal barrier function during the oxygen sensing stage.	Oxygen	203-209	RAR related orphan receptor A	Homo sapiens	40-48
28940930-0	2018	Potential role of the methylation of VEGF gene promoter in response to hypoxia in oxygen-induced retinopathy: beneficial effect of the absence of AQP4.	Oxygen	82-88	vascular endothelial growth factor A	Mus musculus	37-41
28940930-2	2018	In this study, we investigated whether the glial water channel Aquaporin-4 (AQP4) is involved in the hypoxia-dependent VEGF upregulation in the retina of a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	171-177	aquaporin 4	Mus musculus	63-74
28940930-2	2018	In this study, we investigated whether the glial water channel Aquaporin-4 (AQP4) is involved in the hypoxia-dependent VEGF upregulation in the retina of a mouse model of oxygen-induced retinopathy (OIR).	Oxygen	171-177	aquaporin 4	Mus musculus	76-80
29851009-1	2018	Glycerol-3-phosphate is an excellent substrate for FAD-linked mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) in brown adipose tissue mitochondria and is regularly used as the primary substrate to measure oxygen consumption and reactive oxygen consumption by these mitochondria.	Oxygen	214-220	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	112-117
29851009-1	2018	Glycerol-3-phosphate is an excellent substrate for FAD-linked mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) in brown adipose tissue mitochondria and is regularly used as the primary substrate to measure oxygen consumption and reactive oxygen consumption by these mitochondria.	Oxygen	246-252	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	112-117
29851009-4	2018	It was demonstrated that in isolated brown adipose tissue mitochondria (1) mGPDH enzyme activity is maximal at free calcium ion concentrations in the 350 nM-1 muM range, (2) that ROS production also peaks in the 10-100 nM range in the presence of a UCP1 inhibitory ligand (GDP) but wanes with further increasing calcium concentration, and (3) that oxygen consumption rates peak in the 10-100 nM range with rates being maintained at higher calcium concentrations.	Oxygen	348-354	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	75-80
28923780-7	2018	CONCLUSION: Both spindle count and oxygen saturation were recorded to be significantly increased under CPAP titration while there was a significant decrease in apnea-hypopnea.	Oxygen	35-41	centromere protein J	Homo sapiens	103-107
30894785-5	2018	Using Cyp1b1-deficient mice, we showed that CYP1B1 is constitutively expressed in retinal vascular cells with a significant role in retinal neovascularization during oxygen-induced ischemic retinopathy.	Oxygen	166-172	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	6-12
30894785-5	2018	Using Cyp1b1-deficient mice, we showed that CYP1B1 is constitutively expressed in retinal vascular cells with a significant role in retinal neovascularization during oxygen-induced ischemic retinopathy.	Oxygen	166-172	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	44-50
28347773-3	2017	Inhibition of PDKs increases the oxidative phosphorylation of glucose, which may disrupt the balance between the demand and supply of oxygen in cancer cell, thus leading to cell death.	Oxygen	134-140	pyruvate dehydrogenase kinase 1	Homo sapiens	14-18
29042436-10	2017	Exposure to 1% O2 to mimic the low-oxygen conditions in the embryo increased Vegfa expression but did not affect Sox9 mRNA levels in gonadal explants.	Oxygen	15-17	vascular endothelial growth factor A	Mus musculus	77-82
29042436-10	2017	Exposure to 1% O2 to mimic the low-oxygen conditions in the embryo increased Vegfa expression but did not affect Sox9 mRNA levels in gonadal explants.	Oxygen	35-41	vascular endothelial growth factor A	Mus musculus	77-82
29046349-0	2017	Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons.	Oxygen	79-85	Rac family small GTPase 1	Homo sapiens	31-35
29209035-7	2017	Supplemental oxygen administration abrogated the oscillatory shear stress-induced increase in CD31+/CD41b- microparticles, and improved FMD after accounting for the shear stress stimulus.	Oxygen	13-19	integrin subunit alpha 2b	Homo sapiens	100-105
28923783-9	2017	Analysis of renal collecting duct (mIMCD) and tubular epithelial (HK-2) cells stimulated with TGFbeta1 or hypoxia (1% oxygen) to activate Akt provided further evidence that BMP-7 specifically inhibited PI3K/Akt signaling.	Oxygen	118-124	bone morphogenetic protein 7	Mus musculus	173-178
28661035-4	2017	Therefore, we set out to investigate the expression of basigin using a well-characterized mouse model of oxygen-induced retinopathy, which recapitulated hypoxia-induced aberrant neovessel growth.	Oxygen	105-111	basigin	Mus musculus	55-62
28385082-0	2017	Hyperbaric oxygen therapy modulates serum OPG/RANKL in femoral head necrosis patients.	Oxygen	11-17	TNF superfamily member 11	Homo sapiens	46-51
28878027-4	2017	HDAC inhibition induced pathways of cell-cycle arrest, neuronal differentiation, and response to oxygen-containing species, effects also observed in other cancers treated with this class of drugs.	Oxygen	97-103	histone deacetylase 9	Homo sapiens	0-4
29084873-3	2017	Studies of the heme oxygenase mutant (hmox1) of the green alga Chlamydomonas reinhardtii suggest that bilin biosynthesis in plastids is essential for proper regulation of a nuclear gene network implicated in oxygen detoxification during dark-to-light transitions.	Oxygen	20-26	uncharacterized protein	Chlamydomonas reinhardtii	38-43
28972756-6	2017	The other vibrational frequencies for HOSO are reduced relative to the corresponding frequencies in SO2, H2SO4, and the HOS radical making the infrared features of syn-HOSO likely red-shifted in mixed spectral observation, where oxygen, hydrogen, and sulfur are all found.	Oxygen	229-235	synemin	Homo sapiens	164-167
29075011-4	2017	Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF).	Oxygen	47-49	vascular endothelial growth factor A	Mus musculus	164-198
29075011-4	2017	Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF).	Oxygen	47-49	vascular endothelial growth factor A	Mus musculus	200-204
28842250-7	2017	As a result, mitochondrial membrane potential and oxygen consumption are reduced in RAP80 knockdown cells, indicating mitochondrial dysfunction.	Oxygen	50-56	ubiquitin interaction motif containing 1	Homo sapiens	84-89
28975945-6	2017	Mixed cobalt/nickel sulphide, Co9-xNixS8 ONC, shows superior oxygen evolution reaction activity to monometallic sulphide ONC structures, demonstrating the synergy between different metal species.	Oxygen	61-67	phosphoserine phosphatase pseudogene 1	Homo sapiens	30-33
29051216-3	2017	Prolyl 4-hydroxylase domain protein 3 (PHD3) is a cellular oxygen sensor and its expression increased in hypoxia.	Oxygen	59-65	egl-9 family hypoxia inducible factor 3	Homo sapiens	39-43
28846830-4	2017	In addition, syn-selective carbosilylation was achieved through stereoswitching, by using a silylborane having oxygen functionality on the silyl group.	Oxygen	111-117	synemin	Homo sapiens	13-16
28969371-10	2017	Furthermore, an increase in oxygen consumption in TSC2sh cells was detected.	Oxygen	28-34	TSC complex subunit 2	Homo sapiens	50-54
28827059-2	2017	In the presence of oxygen, we demonstrated that glucose consumption, lactate production and lactate dehydrogenase (LDH) activity were significantly increased upon LMP1 expression in NPC cells and in a LMP1 variant derived from NPC patients-transformed BALB/c-3T3 cells.	Oxygen	19-25	PDZ and LIM domain 7	Homo sapiens	163-167
28827059-2	2017	In the presence of oxygen, we demonstrated that glucose consumption, lactate production and lactate dehydrogenase (LDH) activity were significantly increased upon LMP1 expression in NPC cells and in a LMP1 variant derived from NPC patients-transformed BALB/c-3T3 cells.	Oxygen	19-25	PDZ and LIM domain 7	Homo sapiens	201-205
28934392-8	2017	In protecting from alpha-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers cellular reactive oxygen species in mitochondria.	Oxygen	145-151	Neutral Cholesterol Ester Hydrolase homolog	Caenorhabditis elegans	50-56
28499944-7	2017	Moreover, films coated with TiO2-PFH have also shown a permeability to oxygen of 1.70x10-16molm/m2sPa which is 67% lower than uncoated films.	Oxygen	71-77	surfactant protein A2	Homo sapiens	98-101
31966350-0	2017	Anti-angiogenic effect of rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway.	Oxygen	45-51	vascular endothelial growth factor A	Mus musculus	118-122
29031730-8	2017	Furthermore, co-activation of Ppargamma2 with either Prdm16 or Zfp423 transcripts drove distinct thermogenic gene expression patterns associated with increased or decreased oxygen consumption, respectively, mimicking typical characteristics of brite/beige or white cell lineages.	Oxygen	173-179	PR domain containing 16	Mus musculus	53-59
28894274-6	2017	Loss of KDM4A in hypoxic conditions leads to a decreased HIF-1alpha mediated transcriptional response and correlates with a reduction in the characteristics associated with tumour aggressiveness, including invasion, migration, and oxygen consumption.	Oxygen	231-237	lysine demethylase 4A	Homo sapiens	8-13
28780867-7	2017	The effects of excess acid on the electrocatalytic oxygen reduction reaction (ORR) in PILs have been studied, and the onset potential of the ORR in [dema][TfO] increases by 0.8 V upon addition of acid to PIL.	Oxygen	51-57	serpin family A member 2 (gene/pseudogene)	Homo sapiens	86-89
28839225-5	2017	ERO1alpha knockout (KO) by using CRISPR/Cas9 resulted in decreased tumourigenicity in vivo and reduced cell proliferation only under hypoxia in vitro, which suggested that ERO1alpha promotes cancer progression specifically in a low-oxygen environment.	Oxygen	232-238	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	0-9
28839225-5	2017	ERO1alpha knockout (KO) by using CRISPR/Cas9 resulted in decreased tumourigenicity in vivo and reduced cell proliferation only under hypoxia in vitro, which suggested that ERO1alpha promotes cancer progression specifically in a low-oxygen environment.	Oxygen	232-238	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	172-181
28949667-1	2017	Using wide spectral range in situ spectroscopic ellipsometry with systematic ultrahigh vacuum annealing and in situ exposure to oxygen, we report the complex dielectric function of MoS_{2} isolating the environmental effects and revealing the crucial role of unpassivated and passivated sulphur vacancies.	Oxygen	128-134	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	181-185
28745744-0	2017	Spin dependent interactions catalyse the oxygen electrochemistry.	Oxygen	41-47	spindlin 1	Homo sapiens	0-4
28745744-2	2017	Spin dependent potentials via exchange interactions, spin-orbit coupling or through magneto-electric effects catalyse the oxygen electrochemistry.	Oxygen	122-128	spindlin 1	Homo sapiens	0-4
28745744-2	2017	Spin dependent potentials via exchange interactions, spin-orbit coupling or through magneto-electric effects catalyse the oxygen electrochemistry.	Oxygen	122-128	spindlin 1	Homo sapiens	53-57
28745744-6	2017	The influence of spin dependent forces is generally applicable to oxygen catalysis, and supplements the physical interactions relevant for inorganic or organic, electro or photo, artificial or natural processes.	Oxygen	66-72	spindlin 1	Homo sapiens	17-21
28779171-0	2017	LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.	Oxygen	23-29	Protein lin-32	Caenorhabditis elegans	0-6
28779171-4	2017	Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans.	Oxygen	93-99	Protein lin-32	Caenorhabditis elegans	24-30
28665600-4	2017	Interestingly, it is observed that the O2 could participate in the enzymatic reaction directly from gas phase through the proposed nanochannels, and a hydrophobic interface is more favorable for the enzymatic reaction due to the rearrangement of GOx structure as well as the high gas adhesion.	Oxygen	39-41	hydroxyacid oxidase 1	Homo sapiens	246-249
28447205-9	2017	Serum HSP70 levels in preterm humans treated with oxygen were measured by enzyme-linked immunosorbent assay.	Oxygen	50-56	heat shock protein family A (Hsp70) member 4	Homo sapiens	6-11
28316021-0	2017	Hemin protects against oxygen-glucose deprivation-induced apoptosis activation via neuroglobin in SH-SY5Y cells.	Oxygen	23-29	neuroglobin	Homo sapiens	83-94
28947973-4	2017	Hyperbaric oxygen might plays similar roles with the JNK-specific inhibitor SP600125, inducing the increase of Sox-9 and COL2 expression.	Oxygen	11-17	SRY-box transcription factor 9	Rattus norvegicus	111-116
28947973-6	2017	However, Hyperbaric oxygen can inhibits IL-1beta induced inflammatory response in chondrocytes though block the JNK/c-Jun signaling pathway and up-regulate the expression of Sox-9 and COL2.	Oxygen	20-26	SRY-box transcription factor 9	Rattus norvegicus	174-179
28680592-9	2017	PHD3 silencing led to downregulation of most glycolytic enzymes from glucose transport to lactate production supported by the reduction in extracellular acidification and lactate production and increase in cellular oxygen consumption rate.	Oxygen	215-221	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
28362162-4	2017	To that end, we have identified several novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61.	Oxygen	108-114	MDM2 proto-oncogene	Homo sapiens	160-164
28618870-6	2017	Expression of several cartilage-related genes was enhanced by low oxygen tension, including ACAN and HAPLN1.	Oxygen	66-72	aggrecan	Homo sapiens	92-96
28618870-6	2017	Expression of several cartilage-related genes was enhanced by low oxygen tension, including ACAN and HAPLN1.	Oxygen	66-72	hyaluronan and proteoglycan link protein 1	Homo sapiens	101-107
28258342-7	2017	In addition, we demonstrate in lung cancer cell lines exposed to hypoxia or oxidative stress that COL1A1 transcription significantly responds to oxygen depletion, while other genes showed the modest upregulation in stress conditions.	Oxygen	145-151	collagen type I alpha 1 chain	Homo sapiens	98-104
28623968-8	2017	The effect was exacerbated by culture at atmospheric oxygen concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, protein metabolism; apoptosis, inflammatory responses; and diminished trophoblast proliferation, differentiation, invasion, regeneration, and viability.	Oxygen	53-59	CCAAT enhancer binding protein delta	Homo sapiens	128-133
28623968-8	2017	The effect was exacerbated by culture at atmospheric oxygen concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, protein metabolism; apoptosis, inflammatory responses; and diminished trophoblast proliferation, differentiation, invasion, regeneration, and viability.	Oxygen	53-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-181
28259374-5	2017	The data present conflicting results but suggest that the effects of oxygen on restoring kidney function during preservation may be of value for DCD kidneys and/or kidneys that have undergone a period of hypotension, warm ischemia or poor perfusion in the donor.	Oxygen	69-75	dermcidin	Homo sapiens	145-148
28883928-6	2017	METHODS AND ANALYSIS: CPAP IMPACT is a randomised clinical trial comparing bCPAP to low-flow oxygen in the treatment of severe pneumonia among high-risk children 1-59 months of age.	Oxygen	93-99	centromere protein J	Homo sapiens	22-26
32263974-7	2017	The cellular photodynamic activity of TPP 1 NPs was obviously higher than that of TPP 2 NPs, due to the increasing retention of TPP in cancer cells, which will generate more reactive oxygen species in cancer cells under light irradiation.	Oxygen	183-189	tripeptidyl peptidase 1	Homo sapiens	38-43
28674533-6	2017	Moreover, we show that oxygen regulates the expression of CD52, which is a cell surface protein that has been shown to suppress the activation of other T cells upon release.	Oxygen	23-29	CD52 molecule	Homo sapiens	58-62
28730075-0	2017	CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	85-91	vascular endothelial growth factor A	Mus musculus	14-18
28730075-1	2017	AIM: To investigate the role of CCR7/p-ERK1/2/VEGF signaling in the mouse model of oxygen-induced retinopathy (OIR).	Oxygen	83-89	vascular endothelial growth factor A	Mus musculus	46-50
28604836-2	2017	We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products).	Oxygen	327-333	heat shock protein family D (Hsp60) member 1	Homo sapiens	44-65
28604836-2	2017	We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products).	Oxygen	327-333	heat shock protein family D (Hsp60) member 1	Homo sapiens	67-72
28489392-9	2017	Essentially, the charge transfer and spin flip originate from the discontinuous changes of metal-oxygen bond lengths and angles in the compressed atomic structure.	Oxygen	97-103	spindlin 1	Homo sapiens	37-41
28267240-4	2017	MT1-MMP also has a non-protease activity in that it inhibits the oxygen-dependent suppression of hypoxia-inducible factors (HIFs) via Munc18-1-interacting protein 3 (Mint3) and thereby enhances the expression of HIF target genes.	Oxygen	65-71	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	0-7
27829319-5	2017	OBJECTIVE: Evaluation of Sig1R, SOD1, and SOD2 expression in different concentrations of oxygen (1%, 10%, 21%) in colon adenocarcinoma cell lines.	Oxygen	89-95	sigma non-opioid intracellular receptor 1	Homo sapiens	25-30
27829319-10	2017	RESULTS: We observed significant changes in expression of Sig1R, SOD1, SOD2 due to different oxygen concentrations.	Oxygen	93-99	sigma non-opioid intracellular receptor 1	Homo sapiens	58-63
28545138-6	2017	SUMO-4 expression in response to oxidative stress (H2O2: 0, 0.1, 1 and 5mM), as well as, hypoxia-reperfusion (O2: 1%, 8% and 20%) was measured.	Oxygen	53-55	small ubiquitin like modifier 4	Homo sapiens	0-6
28267582-11	2017	Furthermore, alpha-MSH injected into the EWcp had anorexigenic effect, increased oxygen consumption and caused peripheral vasodilation.	Oxygen	81-87	proopiomelanocortin	Rattus norvegicus	13-22
28539891-2	2017	In this experiment, we used small hairpin RNA (shRNA) to interfere with the intracellular oxygen sensor-prolyl hydroxylase 1 (PHD1) and the intracellular oxidative stress sensor-kelch-like ECH associated protein 1 (Keap1) in the hypoxic hepatocytes in order to investigate the function of PHD1and Keap1.	Oxygen	90-96	egl-9 family hypoxia-inducible factor 2	Rattus norvegicus	97-124
28539891-2	2017	In this experiment, we used small hairpin RNA (shRNA) to interfere with the intracellular oxygen sensor-prolyl hydroxylase 1 (PHD1) and the intracellular oxidative stress sensor-kelch-like ECH associated protein 1 (Keap1) in the hypoxic hepatocytes in order to investigate the function of PHD1and Keap1.	Oxygen	90-96	egl-9 family hypoxia-inducible factor 2	Rattus norvegicus	126-130
28477612-4	2017	Analysis of the resulting product ion cross sections yields bond dissociation energies (BDEs, D0) for Gd+-O2 and OGd+-O, where the latter BDE is also independently measured in an exchange reaction between GdO+ and O2.	Oxygen	106-108	homeobox D13	Homo sapiens	88-91
27834582-6	2017	Additionally, in low oxygen conditions ANXA1 was extensively secreted out-side the cells where its binding to formyl peptide receptors (FPRs) induced cell invasion.	Oxygen	21-27	annexin A1	Homo sapiens	39-44
27496203-3	2017	The basal O2 level of perfusate (24.4 +- 0.04 mg L-1 ) was gradually lowered to 3.0 +- 0.01 mg L-1 over 20 min using N2 gas (n = 7).	Oxygen	10-12	ribosomal protein L4	Rattus norvegicus	49-52
27496203-5	2017	During control perfusions (n = 5), the O2 concentration was kept at 26.6 +- 0.3 mg L-1 .	Oxygen	39-41	ribosomal protein L4	Rattus norvegicus	83-86
27496203-7	2017	Heart rate decreased when the oxygen concentration in the perfusate reached 9.1 +- 0.02 mg L-1 and continued to fall in lower oxygen concentrations (F = 14.8, P &lt; 0.001).	Oxygen	30-36	ribosomal protein L4	Rattus norvegicus	91-94
28448515-9	2017	These results suggest that following chronic cocaine use, as cerebral ischemia developed, NOS1, the regulatory protein to counteract blood vessel constriction, was upregulated; meanwhile, the HIF-VEGF pathway was activated to increase microvascular density (i.e., angiogenesis) and thus restore local blood flow and oxygen supply.	Oxygen	316-322	nitric oxide synthase 1	Rattus norvegicus	90-94
28423651-6	2017	The oxygen consumption rate was decreased while the extracellular acidification rate was increased in the SDHB knockout cells.	Oxygen	4-10	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	106-110
28051298-0	2017	The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations.	Oxygen	77-83	lysine demethylase 4A	Homo sapiens	48-53
28051298-3	2017	Recent studies have indicated that the activity of some KDMs, including the pseudogene-encoded KDM4E, may be sensitive to changing oxygen concentrations.	Oxygen	131-137	lysine demethylase 4E	Homo sapiens	95-100
28051298-4	2017	Here, we report detailed analysis of the effect of oxygen availability on the activity of the KDM4 subfamily member KDM4A, importantly demonstrating a high level of O2 sensitivity both with isolated protein and in cells.	Oxygen	51-57	lysine demethylase 4A	Homo sapiens	116-121
28051298-4	2017	Here, we report detailed analysis of the effect of oxygen availability on the activity of the KDM4 subfamily member KDM4A, importantly demonstrating a high level of O2 sensitivity both with isolated protein and in cells.	Oxygen	165-167	lysine demethylase 4A	Homo sapiens	116-121
28051298-6	2017	Furthermore, immunofluorescence experiments in U2OS cells conditionally overexpressing KDM4A showed that the cellular activity of KDM4A against its primary substrate, H3K9me3, displayed a graded response to depleting oxygen concentrations in line with the data obtained using isolated protein.	Oxygen	217-223	lysine demethylase 4A	Homo sapiens	87-92
28051298-6	2017	Furthermore, immunofluorescence experiments in U2OS cells conditionally overexpressing KDM4A showed that the cellular activity of KDM4A against its primary substrate, H3K9me3, displayed a graded response to depleting oxygen concentrations in line with the data obtained using isolated protein.	Oxygen	217-223	lysine demethylase 4A	Homo sapiens	130-135
28051298-7	2017	These results suggest that KDM4A possesses the potential to act as an oxygen sensor in the context of chromatin modifications, with possible implications for epigenetic regulation in hypoxic disease states.	Oxygen	70-76	lysine demethylase 4A	Homo sapiens	27-32
28051298-8	2017	Importantly, this correlation between the oxygen sensitivity of the catalytic activity of KDM4A in biochemical and cellular assays demonstrates the utility of biochemical studies in understanding the factors contributing to the diverse biological functions and varied activity of the 2OG oxygenases.	Oxygen	42-48	lysine demethylase 4A	Homo sapiens	90-95
28279976-2	2017	Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen-independent degradation of HIF-1alpha.	Oxygen	225-231	lysine demethylase 1A	Homo sapiens	21-50
28279976-2	2017	Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen-independent degradation of HIF-1alpha.	Oxygen	225-231	lysine demethylase 1A	Homo sapiens	52-56
28279976-2	2017	Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen-independent degradation of HIF-1alpha.	Oxygen	225-231	receptor for activated C kinase 1	Homo sapiens	105-110
28386126-3	2017	The overexpression of miR-24 decreased mitochondrial H2AX and disrupted mitochondrial function, as indicated by the ATP content, membrane potential and oxygen consumption.	Oxygen	152-158	microRNA 24-1	Mus musculus	22-28
28351984-2	2017	The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits.	Oxygen	29-35	cytochrome b-245, alpha polypeptide	Mus musculus	105-112
28100476-11	2017	In pregnancies complicated by chronic fetal hypoxemia, increasing fetal oxygen concentrations may improve insulin secretion.	Oxygen	72-78	LOC105613195	Ovis aries	106-113
28088729-2	2017	AOX branches from the main respiratory chain, directly coupling the oxidation of ubiquinol with reduction of oxygen to water.	Oxygen	109-115	uncharacterized protein	Chlamydomonas reinhardtii	0-3
28088729-7	2017	The C. reinhardtii AOX2 gene is up-regulated by oxygen or copper deprivation.	Oxygen	48-54	uncharacterized protein	Chlamydomonas reinhardtii	19-23
27909919-1	2017	It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O2-dependent oxidation of L-tryptophan to N-formylkynurenine.	Oxygen	160-162	tryptophan 2,3-dioxygenase	Homo sapiens	63-97
27909919-1	2017	It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O2-dependent oxidation of L-tryptophan to N-formylkynurenine.	Oxygen	160-162	tryptophan 2,3-dioxygenase	Homo sapiens	99-102
28202616-4	2017	In this study, we report that ogg-1-deficient mice exhibited a significant increase of proinflammatory cytokines (TNF-alpha, IL-6, and IFN-gamma) in the lung after being exposed to 95% oxygen.	Oxygen	185-191	8-oxoguanine DNA-glycosylase 1	Mus musculus	30-35
28032259-11	2017	We propose that NQR and AIR12 interact via the quinone, allowing an electron transfer from cytosolic NAD(P)H to apoplastic monodehydroascorbate and control thereby the level of reactive oxygen production and the redox state of the apoplast.	Oxygen	186-192	ARP protein (REF)	Arabidopsis thaliana	16-19
28359291-9	2017	Furthermore, curcumin dramatically decreased mtDNA content and DNA polymerase gamma (POLG) which contributed to reduced mitochondrial oxygen consumption and aerobic glycolysis.	Oxygen	134-140	polymerase (DNA directed), gamma	Mus musculus	85-89
28289217-2	2017	Here, we show that a combined atomic force microscopy/scanning tunneling microscopy (AFM/STM) experiment can both distinguish neutral O2 molecules in the triplet state from negatively charged (O2)- radicals and charge and discharge the molecules at will.	Oxygen	134-136	sulfotransferase family 1A member 3	Homo sapiens	89-92
28289217-2	2017	Here, we show that a combined atomic force microscopy/scanning tunneling microscopy (AFM/STM) experiment can both distinguish neutral O2 molecules in the triplet state from negatively charged (O2)- radicals and charge and discharge the molecules at will.	Oxygen	193-195	sulfotransferase family 1A member 3	Homo sapiens	89-92
28165743-4	2017	Interestingly, the increased potency of compound 27 was facilitated by the formation of a halogen bond with the oxygen of Tyr827 present in the PDE2a active site.	Oxygen	112-118	phosphodiesterase 2A	Rattus norvegicus	144-149
28266574-7	2017	Our findings suggest that integrin beta1 may be an oxygen-sensitive molecule that promotes keratinocyte migration during wound healing and that Notch1 signaling is involved in this process.	Oxygen	51-57	integrin subunit beta 1	Homo sapiens	26-40
28002632-5	2017	At 0.5% oxygen, the expression of both hypoxia-inducible factor (HIF) 1alpha and CXCR4 was greatly enhanced in the rNCSC nuclei and was suppressed by incubation with the CXCR4-specific antagonist AMD3100.	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	39-76
28002632-5	2017	At 0.5% oxygen, the expression of both hypoxia-inducible factor (HIF) 1alpha and CXCR4 was greatly enhanced in the rNCSC nuclei and was suppressed by incubation with the CXCR4-specific antagonist AMD3100.	Oxygen	8-14	C-X-C motif chemokine receptor 4	Rattus norvegicus	81-86
28002632-5	2017	At 0.5% oxygen, the expression of both hypoxia-inducible factor (HIF) 1alpha and CXCR4 was greatly enhanced in the rNCSC nuclei and was suppressed by incubation with the CXCR4-specific antagonist AMD3100.	Oxygen	8-14	C-X-C motif chemokine receptor 4	Rattus norvegicus	170-175
28002632-6	2017	In addition, the rate of cell apoptosis in the rNCSCs cultured at 80% oxygen was dramatically increased, associated with increased nuclear expression of TP53, decreased cytoplasmic expression of TPM1 (tropomyosin-1), and increased nuclear-to-cytoplasmic translocation of S100A2.	Oxygen	70-76	tumor protein p53	Rattus norvegicus	153-157
28002632-8	2017	CONCLUSIONS: Our results show for the first time that extreme oxygen tensions directly control NCSC proliferation differentially via distinct regulatory pathways of proteins, with hypoxia via the HIF1alpha-CXCR4 pathway and hyperoxia via the TP53-TPM1 pathway.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	196-211
28002632-8	2017	CONCLUSIONS: Our results show for the first time that extreme oxygen tensions directly control NCSC proliferation differentially via distinct regulatory pathways of proteins, with hypoxia via the HIF1alpha-CXCR4 pathway and hyperoxia via the TP53-TPM1 pathway.	Oxygen	62-68	tumor protein p53	Rattus norvegicus	242-246
28248201-3	2017	Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenation reaction that also oxidizes hemoglobin to methemoglobin, a non-oxygen-binding form of hemoglobin that readily loses heme.	Oxygen	64-70	hemoglobin subunit gamma 2	Homo sapiens	118-131
28032501-4	2017	In our approach, we utilize a novel "double-sensor" r-PSP that features two spectrally separated emission bands with opposite responses to the O2 pressure, which boosts the sensitivity with respect to traditional reference-sensor pairs.	Oxygen	143-145	microseminoprotein beta	Homo sapiens	54-57
27909858-4	2017	Using immunohistochemistry and confocal microscopy, we observed 10.2 +- 0.6 cells immunoreactive for the vesicular acetylcholine transporter (VAChT) on the efferent aspect of each gill filament, where a high density of serotonergic oxygen-sensitive neuroepithelial cells (NECs) were located.	Oxygen	232-238	solute carrier family 18 member 3b	Danio rerio	105-140
27909858-4	2017	Using immunohistochemistry and confocal microscopy, we observed 10.2 +- 0.6 cells immunoreactive for the vesicular acetylcholine transporter (VAChT) on the efferent aspect of each gill filament, where a high density of serotonergic oxygen-sensitive neuroepithelial cells (NECs) were located.	Oxygen	232-238	solute carrier family 18 member 3b	Danio rerio	142-147
28249151-4	2017	We used quantitative RT-PCR to measure BRCA1 and NBR2 transcript levels in 0% and 1% oxygen in MCF-7 breast cancer cells and found that NBR2 transcript levels increased as a function of time under hypoxic conditions, whereas BRCA1 mRNA levels were repressed.	Oxygen	85-91	BRCA1 DNA repair associated	Homo sapiens	39-44
28456149-8	2017	With regards to physical performance, chemerin was negatively correlated with maximal oxygen uptake (r=-0.572, p=0.013) and squat jump (r=-0.627, p=0.005), but positively related to 10-m sprint (r=0.716, p=0.001) and 30-m sprint (r=0.667, p=0.002) times.	Oxygen	86-92	retinoic acid receptor responder 2	Homo sapiens	38-46
28117339-3	2017	Hearts from transgenic mice overexpressing SNRK have decreased glucose and palmitate metabolism and oxygen consumption, but maintained power and function.	Oxygen	100-106	SNF related kinase	Mus musculus	43-47
27881662-4	2017	We found that O2 levels regulate the subcellular localization and channel activity of the polycystin complex through its interaction with the O2-sensing prolyl hydroxylase domain containing protein EGLN3 (or PHD3), which hydroxylates PC1.	Oxygen	14-16	egl-9 family hypoxia inducible factor 3	Homo sapiens	198-203
27881662-4	2017	We found that O2 levels regulate the subcellular localization and channel activity of the polycystin complex through its interaction with the O2-sensing prolyl hydroxylase domain containing protein EGLN3 (or PHD3), which hydroxylates PC1.	Oxygen	14-16	egl-9 family hypoxia inducible factor 3	Homo sapiens	208-212
27883312-7	2017	Reverse transcription-quantitative PCR (RT-qPCR) analysis confirmed that the lysine methyltransferase EFM6 and the recombinase DMC1, both conserved in humans, are indeed oxygen-responsive.	Oxygen	170-176	DNA meiotic recombinase 1	Homo sapiens	127-131
28685462-2	2017	Both 1/T 1 and 1/T 2 increase with increasing oxygen concentration.	Oxygen	46-52	solute carrier family 25 member 5	Homo sapiens	17-20
27729002-10	2017	miR-30 inhibitors induced a decrease in mitochondrial oxygen consumption, cytoplasmic release of cytochrome c, and activation of Caspase 3 and 9, activating mitochondrial apoptotic pathway.	Oxygen	54-60	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
28278498-9	2017	CONCLUSION: Our data indicate that oxygen availability can function as a local modulator of CD4+ T cell responses and thus influences tumour immune surveillance in inflammation-associated colon cancer.	Oxygen	35-41	CD4 antigen	Mus musculus	92-95
27353127-6	2017	Results Peak oxygen uptake evolved in the PS0, PS3 and PS6 groups from 11.5 +- 2.3 to 12.6 +- 2.8 and 12.0 +- 2.7 mL/kg/min, respectively.	Oxygen	13-19	taste 2 receptor member 63 pseudogene	Homo sapiens	55-58
29147462-8	2017	Small interfering RNA against Nox4 reduced ROS production induced by 20% O2 and consequently suppressed premature senescence of NP cells.	Oxygen	73-75	NADPH oxidase 4	Rattus norvegicus	30-34
29147462-11	2017	This study, for the first time, demonstrates that Nox4 is an oxygen-sensing enzyme and a main ROS source in NP cells.	Oxygen	61-67	NADPH oxidase 4	Rattus norvegicus	50-54
29387292-9	2017	Likewise, kallistatin stimulates eNOS and HIF-1, and kallistatin antisense RNA abolishes oxygen-induced eNOS and HIF-1 expression, indicating a role of kallistatin in mediating mild oxygen"s stimulation on antioxidant genes.	Oxygen	182-188	serpin family A member 4	Homo sapiens	53-64
29387292-10	2017	Protein kinase C (PKC) activation mediates HIF-1-induced eNOS synthesis in response to hyperoxia/exercise; thus, mild oxygen through PKC activation stimulates kallistatin-mediated HIF-1 and eNOS synthesis.	Oxygen	118-124	serpin family A member 4	Homo sapiens	159-170
29387292-11	2017	In summary, oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1-eNOS-NO pathway.	Oxygen	99-105	serpin family A member 4	Homo sapiens	62-73
29387292-11	2017	In summary, oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1-eNOS-NO pathway.	Oxygen	169-175	serpin family A member 4	Homo sapiens	125-136
28056323-0	2017	[The role of neuroglobin in oxygen-glucose deprivation and reoxygenation-induced mitochondrial depolarization and reactive oxygen species production in SH-SY5Y cells].	Oxygen	28-34	neuroglobin	Homo sapiens	13-24
28056323-1	2017	Objective: To investigate the role of neuroglobin (NGB) in oxygen-glucose deprivation and reoxygenation (OGD/R) induced mitochondrial depolarization and reactive oxygen species (ROS)production in a human neuroblastoma cell line (SH-SY5Y).	Oxygen	59-65	neuroglobin	Homo sapiens	38-49
28056323-1	2017	Objective: To investigate the role of neuroglobin (NGB) in oxygen-glucose deprivation and reoxygenation (OGD/R) induced mitochondrial depolarization and reactive oxygen species (ROS)production in a human neuroblastoma cell line (SH-SY5Y).	Oxygen	59-65	neuroglobin	Homo sapiens	51-54
27858028-5	2016	The thermal decomposition behaviors of the salt are tested, indicating that the salt has good thermal stability with a decomposition temperature above 200  C. The enthalpy of formation for the salt is dependent on the combustion heat date measured by oxygen bomb calorimetry with a result of 425.6 kJ mol-1, which is the same level as TKX-50, and four times higher than that of RDX.	Oxygen	251-257	radixin	Homo sapiens	378-381
27916458-7	2016	In vivo exposure of a mouse to low environmental oxygen causes Gucy1b2-dependent activation of olfactory bulb neurons in the vicinity of the glomeruli formed by axons of Gucy1b2+ sensory neurons.	Oxygen	49-55	guanylate cyclase 1, soluble, beta 2	Mus musculus	63-70
27916458-7	2016	In vivo exposure of a mouse to low environmental oxygen causes Gucy1b2-dependent activation of olfactory bulb neurons in the vicinity of the glomeruli formed by axons of Gucy1b2+ sensory neurons.	Oxygen	49-55	guanylate cyclase 1, soluble, beta 2	Mus musculus	170-177
27916458-8	2016	Low environmental oxygen also induces conditioned place aversion, for which Gucy1b2 and Trpc2 are required.	Oxygen	18-24	guanylate cyclase 1, soluble, beta 2	Mus musculus	76-83
27978745-1	2016	A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10, and C13.	Oxygen	136-142	homeobox C13	Homo sapiens	180-183
27951646-1	2016	Since its discovery, neuroglobin (Ngb), a neuron-specific oxygen binding hemoglobin, distinct from the classical myoglobin and blood hemoglobin, has attracted attention as an endogenous neuroprotectant.	Oxygen	58-64	neuroglobin	Homo sapiens	21-32
27951646-1	2016	Since its discovery, neuroglobin (Ngb), a neuron-specific oxygen binding hemoglobin, distinct from the classical myoglobin and blood hemoglobin, has attracted attention as an endogenous neuroprotectant.	Oxygen	58-64	neuroglobin	Homo sapiens	34-37
27951658-1	2016	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme-containing enzymes that catalyze the O2-dependent oxidation of l-tryptophan (l-Trp) in biological systems.	Oxygen	117-119	tryptophan 2,3-dioxygenase	Homo sapiens	38-64
27951658-1	2016	Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme-containing enzymes that catalyze the O2-dependent oxidation of l-tryptophan (l-Trp) in biological systems.	Oxygen	117-119	tryptophan 2,3-dioxygenase	Homo sapiens	66-69
27933800-1	2016	The present study uses CO as a surrogate for oxygen to probe how substrate binding triggers oxygen activation in peptidylglycine monooygenase (PHM).	Oxygen	45-51	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	143-146
27933800-1	2016	The present study uses CO as a surrogate for oxygen to probe how substrate binding triggers oxygen activation in peptidylglycine monooygenase (PHM).	Oxygen	92-98	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	143-146
27519633-5	2016	Low oxygen level reduced SIRT1, whereas activation of SIRT1 by resveratrol increased mitochondrial replication and decreased cellular proliferation with reduction of phosphorylated mTOR.	Oxygen	4-10	sirtuin 1	Bos taurus	25-30
27519633-6	2016	These results suggest that low oxygen level stimulates the HIF1-VEGF-AKT-mTOR pathway and up-regulates glycolysis, which contributes to GC proliferation, and downregulation of SIRT1 contributes to hypoxia-associated reduction of mitochondria and cellular proliferation.	Oxygen	31-37	vascular endothelial growth factor A	Bos taurus	64-68
27519633-6	2016	These results suggest that low oxygen level stimulates the HIF1-VEGF-AKT-mTOR pathway and up-regulates glycolysis, which contributes to GC proliferation, and downregulation of SIRT1 contributes to hypoxia-associated reduction of mitochondria and cellular proliferation.	Oxygen	31-37	sirtuin 1	Bos taurus	176-181
27482635-2	2016	We earlier identified IL-1 receptor antagonist (IL-1Ra) as a potent inhibitor of murine BPD induced by combining perinatal inflammation (intraperitoneal LPS to pregnant dams) and exposure of pups to hyperoxia (fraction of inspired oxygen = 0.65).	Oxygen	231-237	interleukin 1 receptor antagonist	Mus musculus	22-46
27482635-2	2016	We earlier identified IL-1 receptor antagonist (IL-1Ra) as a potent inhibitor of murine BPD induced by combining perinatal inflammation (intraperitoneal LPS to pregnant dams) and exposure of pups to hyperoxia (fraction of inspired oxygen = 0.65).	Oxygen	231-237	interleukin 1 receptor antagonist	Mus musculus	48-54
27683212-2	2016	Specific taxa of SRB and SOB were correlated with some abiotic factors, such as the source of the wastewater, oxygen content, sample type, and physical chemical attributes of these WWTPs.	Oxygen	110-116	chaperonin containing TCP1 subunit 4	Homo sapiens	17-20
27718044-5	2016	Through the interaction with RGD-containing ligand, the integrin alphavbeta3 forms carboxylate oxygen noncovalent, which is further stabilized by accompanied electrostatic interaction between the Ca2+ and the beta3 subunit.	Oxygen	95-101	integrin subunit alpha V	Homo sapiens	56-76
30996862-0	2016	Dioxygen insertion into the gold(i)-hydride bond: spin orbit coupling effects in the spotlight for oxidative addition.	Oxygen	0-8	spindlin 1	Homo sapiens	50-54
30996862-1	2016	O2 insertion into a Au(i)-H bond occurs through an oxidative addition/recombination mechanism, showing peculiar differences with respect to Pd(ii)-H, for which O2 insertion takes place through a hydrogen abstraction mechanism in the triplet potential energy surface with a pure spin transition state.	Oxygen	0-2	spindlin 1	Homo sapiens	278-282
27760279-2	2016	In the first step, O2 activation involves one electron being provided to the heme by an enzyme-bound 6R-tetrahydro-l-biopterin cofactor (H4 B), and the H4 B radical must be reduced back to H4 B in order for NOS to continue catalysis.	Oxygen	19-21	H4 clustered histone 4	Homo sapiens	137-141
27760279-2	2016	In the first step, O2 activation involves one electron being provided to the heme by an enzyme-bound 6R-tetrahydro-l-biopterin cofactor (H4 B), and the H4 B radical must be reduced back to H4 B in order for NOS to continue catalysis.	Oxygen	19-21	H4 clustered histone 4	Homo sapiens	152-156
27760279-2	2016	In the first step, O2 activation involves one electron being provided to the heme by an enzyme-bound 6R-tetrahydro-l-biopterin cofactor (H4 B), and the H4 B radical must be reduced back to H4 B in order for NOS to continue catalysis.	Oxygen	19-21	H4 clustered histone 4	Homo sapiens	152-156
27760279-9	2016	This supports a model where the heme porphyrin transfers an electron from the NOS flavoprotein to the H4 B radical formed during catalysis, revealing that the heme plays a dual role in catalyzing O2 activation or electron transfer at distinct points in the reaction cycle.	Oxygen	196-198	H4 clustered histone 4	Homo sapiens	102-106
27801576-5	2016	Complexes 1 and 2 decompose in the presence of O2 to yield the corresponding sulfinic acid (RSO2H) products, thereby emulating the reactivity of the TDO enzymes and related complexes.	Oxygen	47-49	tryptophan 2,3-dioxygenase	Homo sapiens	149-152
27801576-7	2016	Treatment of the TDO models with nitric oxide (NO)-a well-established surrogate of O2-led to a mixture of high-spin and low-spin {FeNO}7 species at low temperature (-70  C), as indicated by electron paramagnetic resonance (EPR) spectroscopy.	Oxygen	83-85	tryptophan 2,3-dioxygenase	Homo sapiens	17-20
27799543-6	2016	Interestingly, NDUFS1 knockdown in neurons decreased the association of complex I into supercomplexes, leading to impaired oxygen consumption and increased mitochondrial ROS.	Oxygen	123-129	NADH:ubiquinone oxidoreductase core subunit S1	Homo sapiens	15-21
27767308-12	2016	The experimental GdO+ BDE measured here combined with the known IE of Gd is used to determine an exothermicity of 1.54 +- 0.10 eV for the Gd chemi-ionization reaction with atomic oxygen.	Oxygen	179-185	homeobox D13	Homo sapiens	22-25
27443962-5	2016	We further carried out functional analysis of the identified genes in Abeta expressing C. elegans strain CL4176 [myo-3/Abeta1-42 long 3"-UTR] via studying effect on Abeta induced toxicity, cholinergic neuroanatomy, content of acetylcholine/acetylcholine-esterase, extent of reactive oxygen species and expression of FOXO transcription factor DAF-16.	Oxygen	283-289	Myosin-3	Caenorhabditis elegans	113-118
27439950-3	2016	The strongly-fluorescent syn-bimane chelates the Pd(ii) center via its carbonyl oxygen atoms, affording a non-fluorescent complex.	Oxygen	80-86	synemin	Homo sapiens	25-28
27762317-2	2016	Here we report the crystal structure of human TDO (hTDO) in a ternary complex with the substrates L-Trp and O2 and in a binary complex with the product N-formylkynurenine (NFK), defining for the first time the binding modes of both substrates and the product of this enzyme.	Oxygen	108-110	tryptophan 2,3-dioxygenase	Homo sapiens	46-49
27762317-2	2016	Here we report the crystal structure of human TDO (hTDO) in a ternary complex with the substrates L-Trp and O2 and in a binary complex with the product N-formylkynurenine (NFK), defining for the first time the binding modes of both substrates and the product of this enzyme.	Oxygen	108-110	tryptophan 2,3-dioxygenase	Homo sapiens	51-55
27125949-3	2016	METHODS AND RESULTS: Mice deficient for oxygen sensor HIF-prolyl hydroxylase 1 (PHD1) were backcrossed onto an atherogenic low-density lipoprotein receptor (LDLR) knockout background and atherosclerosis was studied upon 8 weeks of western-type diet.	Oxygen	40-46	egl-9 family hypoxia-inducible factor 2	Mus musculus	54-78
27658969-4	2016	Combined with the first-principle calculations, the results suggest that the bonding with Fe and Ga or As ions and the ionic distortion near the interface, as well as the FeO defects and oxygen vacancies, may increase the spin-orbit coupling in ultrathin Fe3O4 epitaxial films and in turn provide an enhanced damping.	Oxygen	187-193	spindlin 1	Homo sapiens	222-226
27701455-12	2016	Nevertheless, HBEGF upregulation at 2% O2 was blocked when the miRNA-processing protein DGCR8 was silenced, suggesting a role for miRNA.	Oxygen	39-41	DGCR8 microprocessor complex subunit	Homo sapiens	88-93
27545759-2	2016	During hypoxia, the catalyitc activity of JMJD3 is reduced due to the limited availability of O2 as a substrate.	Oxygen	94-96	lysine demethylase 6B	Homo sapiens	42-47
27516541-7	2016	The product of fiber cross-sectional area and SDH-OD (integrated SDH) indicated the maximal oxygen consumption of that fiber.	Oxygen	92-98	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	46-49
27516541-7	2016	The product of fiber cross-sectional area and SDH-OD (integrated SDH) indicated the maximal oxygen consumption of that fiber.	Oxygen	92-98	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	65-68
27516541-8	2016	The maximal oxygen consumption supported by a capillary was calculated as the integrated SDH in its supply area.	Oxygen	12-18	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	89-92
27816999-7	2016	Moreover, when expressed in yeast, Pacific oyster AOX is a functional quinol oxidase, conferring cyanide-resistant growth and myxothiazol-resistant oxygen consumption to yeast cells and isolated mitochondria.	Oxygen	148-154	alternative oxidase, mitochondrial-like	Crassostrea gigas	50-53
27518221-8	2016	Meanwhile, overexpression of SlNAM1 improved the osmolytes contents and reduced the H2O2 and O2 - contents under low temperature, which contribute to alleviating the oxidative damage of cell membrane after chilling stress.	Oxygen	86-88	Nam-like protein 1	Solanum lycopersicum	29-35
27765004-3	2016	We hypothesized that hyperbaric oxygen therapy (HBOT) may alleviate MARF by inducing renal HO-1 expression.	Oxygen	32-38	heme oxygenase 1	Rattus norvegicus	91-95
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Oxygen	266-272	CDGSH iron sulfur domain 2	Homo sapiens	32-37
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Oxygen	266-272	CDGSH iron sulfur domain 2	Homo sapiens	94-99
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Oxygen	266-272	CDGSH iron sulfur domain 2	Homo sapiens	94-99
27611801-9	2016	Taken together, a novel MDH2 inhibitor, compound 7, suppressed HIF-1alpha accumulation via reduction of oxygen consumption and ATP production, integrating metabolism into anti-cancer efficacy in cancer cells.	Oxygen	104-110	malate dehydrogenase 2	Homo sapiens	24-28
27238976-3	2016	In the present study, the actions of a protease activated receptor-1 activating peptide (PAR-1 AP) SFLLRN-NH2 were investigated in an in vivo rat model of ischaemic stroke induced by middle cerebral artery occlusion (MCAO) and in an in vitro model induced by oxygen and glucose deprivation (OGD) in primary cultured rat embryonic cortical neurones.	Oxygen	259-265	coagulation factor II (thrombin) receptor	Rattus norvegicus	89-94
27337995-5	2016	P49/STRAP also reduced mitochondrial size, mitochondrial membrane potential and the mitochondrial oxygen consumption rate.	Oxygen	98-104	serum response factor binding protein 1	Homo sapiens	0-3
32480511-6	2016	Additionally, proline biosynthesis Arabidopsis knockout (KO) mutant plants of Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) gene, designated as Atp5cs1-1 and Atp5cs1-4, showed similar protein nitration levels as wild-type plants under salinity-induced oxidative stress, despite mutants having higher levels of lipid oxidation, H2O2 and superoxide (O2 -).	Oxygen	355-359	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	78-122
32480511-6	2016	Additionally, proline biosynthesis Arabidopsis knockout (KO) mutant plants of Delta(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) gene, designated as Atp5cs1-1 and Atp5cs1-4, showed similar protein nitration levels as wild-type plants under salinity-induced oxidative stress, despite mutants having higher levels of lipid oxidation, H2O2 and superoxide (O2 -).	Oxygen	355-359	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	124-129
27567805-5	2016	Moreover, PARP-1 activation contributes to the functional energetic decline affecting cytochrome oxidase IV protein levels, oxygen consumption rates, and membrane potential, resulting in cellular bioenergetic deficit.	Oxygen	124-130	poly (ADP-ribose) polymerase family, member 1	Mus musculus	10-16
27250824-0	2016	Hb San Cataldo [beta144(HC1)Lys Thr; HBB: C.434A &gt; C]: A New Hemoglobin Variant with Increased Affinity for Oxygen.	Oxygen	111-117	CYCS pseudogene 39	Homo sapiens	24-27
27327106-4	2016	When spin crossing during oxygen dissociation on the clusters is considered, the activation energies decrease by 10-29 kJ mol(-1); however, they are still high due to the magic nature of the clusters and high vertical spin excitation energies.	Oxygen	26-32	spindlin 1	Homo sapiens	5-9
27327106-4	2016	When spin crossing during oxygen dissociation on the clusters is considered, the activation energies decrease by 10-29 kJ mol(-1); however, they are still high due to the magic nature of the clusters and high vertical spin excitation energies.	Oxygen	26-32	spindlin 1	Homo sapiens	218-222
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Oxygen	192-198	spindlin 1	Homo sapiens	4-8
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Oxygen	192-198	spindlin 1	Homo sapiens	9-13
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Oxygen	192-198	spindlin 1	Homo sapiens	9-13
27426264-0	2016	Fabrication of Mediatorless/Membraneless Glucose/Oxygen Based Biofuel Cell using Biocatalysts Including Glucose Oxidase and Laccase Enzymes.	Oxygen	49-55	hydroxyacid oxidase 1	Homo sapiens	104-119
26812179-2	2016	The ether oxygen is linked to the (CF2) carbon atom, with a C-O distance of 2.908 A.	Oxygen	10-16	ATPase H+ transporting accessory protein 1	Homo sapiens	35-38
27018294-10	2016	Thus hypoxia-activated Rac1 is critical for neuronal HIF-1alpha stabilization and survival during oxygen deprivation via integration of complex signaling cascades.	Oxygen	98-104	Rac family small GTPase 1	Homo sapiens	23-27
26370669-3	2016	It has been suggested that the protein neuroglobin (Ngb), which is found in high concentrations within the retina, may help to maintain an adequate supply of oxygen via the processes of transport and storage.	Oxygen	158-164	neuroglobin	Homo sapiens	39-50
26370669-3	2016	It has been suggested that the protein neuroglobin (Ngb), which is found in high concentrations within the retina, may help to maintain an adequate supply of oxygen via the processes of transport and storage.	Oxygen	158-164	neuroglobin	Homo sapiens	52-55
26370669-5	2016	Numerical simulations show that Ngb may play an important role in oxygen transport, but not in storage.	Oxygen	66-72	neuroglobin	Homo sapiens	32-35
26370669-6	2016	Our models predict that the retina is most susceptible to hypoxia in the regions of the photoreceptor inner segment and inner plexiform layers, where Ngb has the potential to prevent hypoxia and increase oxygen uptake by 30-40 %.	Oxygen	204-210	neuroglobin	Homo sapiens	150-153
26370669-7	2016	Analysis of a simplified model confirms the utility of Ngb in transport and shows that its oxygen affinity ([Formula: see text] value) is near optimal for this process.	Oxygen	91-97	neuroglobin	Homo sapiens	55-58
27323329-0	2016	PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.	Oxygen	33-39	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-5
29235764-5	2016	Under decreased cytochrome b5 levels the electrons are transferred to oxygen, which leads to heightened generation of superoxide (O2 -) in comparison to control.	Oxygen	70-76	cytochrome b5 type A	Rattus norvegicus	16-29
27297042-0	2016	TLR2/4 deficiency prevents oxygen-induced vascular degeneration and promotes revascularization by downregulating IL-17 in the retina.	Oxygen	27-33	interleukin 17A	Mus musculus	113-118
26976766-0	2016	Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells.	Oxygen	117-123	purinergic receptor P2Y14	Rattus norvegicus	59-64
26719943-0	2016	In vivo photoacoustic tomography of myoglobin oxygen saturation.	Oxygen	46-52	myoglobin	Mus musculus	36-45
26719943-1	2016	Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities.	Oxygen	26-32	myoglobin	Mus musculus	0-9
26719943-1	2016	Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities.	Oxygen	120-122	myoglobin	Mus musculus	0-9
26719943-2	2016	We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb ).	Oxygen	123-129	myoglobin	Mus musculus	144-153
27059084-8	2016	We demonstrate that low oxygen stimulates a complex signaling network involving PI3K/Akt, Notch, and canonical Wnt pathways, which mediate the observed increase in nuclear Oct4a and REST, with simultaneous decrease in p53, AIF, and Bak.	Oxygen	24-30	BCL2 antagonist/killer 1	Homo sapiens	232-235
28539802-0	2016	Targeting VEGF in canine oxygen-induced retinopathy - a model for human retinopathy of prematurity.	Oxygen	25-31	vascular endothelial growth factor A	Canis lupus familiaris	10-14
26934491-4	2016	This view is supported by the isolation of [1-mu2 -DMF][OTf]2 , an adduct, in which the DMF oxygen atom bridges the two antimony centers.	Oxygen	92-98	POU class 2 homeobox 2	Homo sapiens	56-61
27088801-2	2016	Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesis in the kidney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cellular oxygen sensors.	Oxygen	138-144	egl-9 family hypoxia-inducible factor 2	Mus musculus	149-153
27135742-10	2016	Consistently, homologous recombination-defective cells accumulate spontaneous gammaH2AX or XRCC1 foci that are abolished by treatment with N-acetyl-cysteine or maintenance at 3% O2.	Oxygen	178-180	X-ray repair cross complementing 1	Homo sapiens	91-96
26972278-7	2016	Consistent with these observations, the mitochondrial oxygen consumption rate was significantly reduced in the Akt3-knockdown cells.	Oxygen	54-60	AKT serine/threonine kinase 3	Homo sapiens	111-115
26844625-1	2016	Vasa vasorum supply both the tunica adventitia and the tunica media of major arteries with nutrients and oxygen.	Oxygen	105-111	DEAD-box helicase 4	Sus scrofa	0-4
26966066-0	2016	PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARgamma via PEDF-R in H9c2 cells.	Oxygen	44-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	117-126
27066534-4	2016	Scn1Lab mutant zebrafish showed a decrease in baseline glycolytic rate and oxygen consumption rate (OCR) compared to controls.	Oxygen	75-81	sodium channel, voltage-gated, type I like, alpha b	Danio rerio	0-7
26965786-12	2016	Furthermore, reaction of WT PHM with CO (an oxygen analogue) produced the M site CO complex, which showed a unique XES spectrum that could be computationally reproduced by including interactions between Cu(I) and the CO ligand.	Oxygen	44-50	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	28-31
26723502-4	2016	Combined treatment of high NaCl (0.15M) with sub-effective IL-17 (0.1 nM) induced enhanced growth in breast cancer cells along with activation of reactive nitrogen and oxygen (RNS/ROS) species known to promote cancer.	Oxygen	168-174	interleukin 17A	Homo sapiens	59-64
26746865-10	2016	Bath-application of 10 microg/ml adenosine deaminase during oxygen/glucose deprivation significantly attenuated the oxygen/glucose deprivation-induced reduction in levels of eFP and optFP.	Oxygen	60-66	adenosine deaminase	Rattus norvegicus	33-52
26746865-10	2016	Bath-application of 10 microg/ml adenosine deaminase during oxygen/glucose deprivation significantly attenuated the oxygen/glucose deprivation-induced reduction in levels of eFP and optFP.	Oxygen	116-122	adenosine deaminase	Rattus norvegicus	33-52
26746865-11	2016	The number of injured cells decreased significantly, and western blot analysis indicated a significant decrease of autophagic signaling in the adenosine deaminase-treated oxygen/glucose deprivation slices.	Oxygen	171-177	adenosine deaminase	Rattus norvegicus	143-162
25636685-8	2016	Our findings suggest that neuroglobin is well positioned to play an important physiologic role in the oxygen homeostasis of the peripheral and central auditory nervous system, and provides the first evidence that Ngb signal differentiates the central projections of the inner and outer hair cells.	Oxygen	102-108	neuroglobin	Homo sapiens	26-37
26525200-7	2016	Preoperative oxygen saturation measurements correlated inversely with FGF23 levels.	Oxygen	13-19	fibroblast growth factor 23	Homo sapiens	70-75
26892905-7	2016	Treatment with Ar and O2 enabled a dual electrical characteristic of the field effect transistor (FET) that featured linear and saturated responses of different magnitudes in the Ids-Vds curves, whereas the pristine MoS2 FET displayed only a linear electrical dependency.	Oxygen	22-24	iduronate 2-sulfatase	Homo sapiens	179-182
26919583-0	2016	Photoinitiated Reactivity of a Thiolate-Ligated, Spin-Crossover Nonheme {FeNO}(7) Complex with Dioxygen.	Oxygen	95-103	spindlin 1	Homo sapiens	49-53
26708631-2	2016	The second objective was to evaluate the effect of tumor growth inhibition related to a tumor niche factor - oxygen deprivation - as hypoxia develops along with the anti-angiogenic activity of tyrosine kinase inhibitors in renal tumors.	Oxygen	109-115	TXK tyrosine kinase	Homo sapiens	193-208
26801556-6	2016	Furthermore, TRB3 overexpression resulted in significantly lower oxygen consumption rates for basal and proton leakage, indicating decreased BAT activity.	Oxygen	65-71	tribbles pseudokinase 3	Homo sapiens	13-17
26875667-7	2016	Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner.	Oxygen	76-82	ATM interactor	Homo sapiens	14-19
27218057-13	2016	CONCLUSIONS: According to the results of this study, oxygen therapy by mechanical ventilator in the first 6 hours after injury in patients with severe TBI can improve the final GOS, Barthel index, and mRS scores.	Oxygen	53-59	sterile alpha motif domain containing 11	Mus musculus	201-204
26634655-4	2016	APPROACH AND RESULTS: Depletion of LRP1 in endothelial cells results in increased retinal neovascularization in a mouse model of oxygen-induced retinopathy.	Oxygen	129-135	low density lipoprotein receptor-related protein 1	Mus musculus	35-39
26691907-7	2016	Using transfection of pCDNA3.1-HIF-1alpha on HUVEC cells, HIF-1alpha significantly activated NFkappaB transcription at hypoxic conditions (1% O2), and concurrent with increased expression of IL-1beta and TNF-alpha.	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	31-41
26691907-7	2016	Using transfection of pCDNA3.1-HIF-1alpha on HUVEC cells, HIF-1alpha significantly activated NFkappaB transcription at hypoxic conditions (1% O2), and concurrent with increased expression of IL-1beta and TNF-alpha.	Oxygen	142-144	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	58-68
26599691-9	2016	Among phenol sulfotransferase SULT1A1 was not sensitive to studied factors, whereas the expression of SULT1A3 was depended on oxygen only in minimal medium.	Oxygen	126-132	sulfotransferase family 1A member 3	Homo sapiens	102-109
27373039-5	2016	RESULT: The lowest average oxygen saturation and the average blood oxygen saturation improved significantly after CPAP therapy, and the longest sleep apnea time and AHI decreased obviously (P &lt; 0.01).	Oxygen	27-33	centromere protein J	Homo sapiens	114-118
27373039-5	2016	RESULT: The lowest average oxygen saturation and the average blood oxygen saturation improved significantly after CPAP therapy, and the longest sleep apnea time and AHI decreased obviously (P &lt; 0.01).	Oxygen	67-73	centromere protein J	Homo sapiens	114-118
26510737-1	2016	PURPOSE: Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.	Oxygen	17-23	C-X-C motif chemokine receptor 4	Homo sapiens	135-140
26909929-7	2016	Hyperbaric oxygen treatment significantly increased the expression of nuclear Nrf2 protein (P &lt; 0.05), HO-1, and NQO-1 in the brain tissues surrounding the lesion after a traumatic brain injury (P &lt; 0.05) and also significantly reduced the number of apoptotic and injured nerve cells.	Oxygen	11-17	heme oxygenase 1	Rattus norvegicus	106-110
26937455-3	2016	Here we used a model of oxidative stress by employing glucose/glucose oxidase (GOx), which (based on the availability of glucose and oxygen) is known to produce H2O2.	Oxygen	133-139	hydroxyacid oxidase 1	Homo sapiens	79-82
26813160-2	2016	We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown.	Oxygen	56-62	fibroblast growth factor 10	Mus musculus	26-31
26805846-4	2016	The tyrosinase target can catalyze the oxidization of tyrosine by oxygen into ortho-benzoquinone residues, which results in a decrease in the sensor photocurrent.	Oxygen	66-72	tyrosinase	Homo sapiens	4-14
26642085-16	2016	In addition, the potential applications of the developed CNF aerogel based functional materials are also highlighted in this Account, including stretchable conductors, oxygen reduction reaction catalysts, supercapacitors, lithium-ion battery, and oil cleanup.	Oxygen	168-174	NPHS1 adhesion molecule, nephrin	Homo sapiens	57-60
26787841-10	2016	The results presented here support the hypothesis that miR-211 loss in melanoma cells causes abnormal regulation of energy metabolism, which in turn allows cancer cells to survive under low oxygen concentrations-a condition that generally kills normal cells.	Oxygen	190-196	microRNA 211	Homo sapiens	55-62
26586906-4	2016	Continuous flow insufflation of oxygen (CFI) allows noninterrupted CC and generates positive airway pressure (Paw).	Oxygen	32-38	complement factor I	Homo sapiens	40-43
26753564-9	2016	Interestingly, hypoxic exposure markedly activated the PERK pathway in HCC cells in vitro, suggesting that PlGF inhibition may diminish PERK activation by improving oxygen delivery.	Oxygen	165-171	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	55-59
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	Oxygen	62-68	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	106-111
27343104-0	2016	Multigenerational Effects of Rearing Atmospheric Oxygen Level on the Tracheal Dimensions and Diffusing Capacities of Pupal and Adult Drosophila melanogaster.	Oxygen	49-55	Partner of Bursicon	Drosophila melanogaster	117-122
27343104-4	2016	Here we tested whether rearing in 10, 21, or 40 kPa atmospheric oxygen atmospheres for 5-7 generations affected the tracheal dimensions and diffusing capacities of pupal and adult Drosophila.	Oxygen	64-70	Partner of Bursicon	Drosophila melanogaster	164-169
27343104-5	2016	Abdominal tracheae and pupal snorkel tracheae showed weak responses to oxygen, while leg tracheae showed strong, but imperfect compensatory changes.	Oxygen	71-77	Partner of Bursicon	Drosophila melanogaster	23-28
26603154-4	2016	APPROACH AND RESULTS: We used 2 mouse models of ONV, choroidal neovascularization and oxygen-induced retinopathy, to show that Vegfa is highly expressed by several cell types, but not myeloid cells during ONV.	Oxygen	86-92	vascular endothelial growth factor A	Mus musculus	127-132
26523859-6	2016	Explants cultured at higher oxygen tension released constitutive proMMP-2, proMMP-9, TIMP-1, and TIMP-2.	Oxygen	28-34	TIMP metallopeptidase inhibitor 2	Homo sapiens	97-103
26704260-6	2016	Functionally, axin expression reduced the activity of OXPHOS complex IV and the oxygen consumption rate (OCR), suggesting axin-mediated mitochondrial dysfunction.	Oxygen	80-86	axin 1	Homo sapiens	14-18
25260402-4	2016	Diacron-reactive oxygen metabolite (dROM) levels were measured in patients with PAF (n = 50) and PSAF (n = 35) at different cardiac sites before ablation and in peripheral vein 3 months after ablation.	Oxygen	17-23	Drosomycin	Drosophila melanogaster	36-40
26904233-1	2016	On October 27, 2015, Lemile and colleagues published an article in JAMA entitled "Effect of Noninvasive Ventilation vs. Oxygen Therapy on Mortality among Immunocompromised Patients with Acute Respiratory Failure: A Randomized Clinical Trial", which investigated the effects of non-invasive ventilation (NIV) in 28-day mortality of 374 critically ill immunosuppressed patients.	Oxygen	120-126	F11 receptor	Homo sapiens	67-71
26477504-0	2016	Superoxide dismutase 1 and glutathione peroxidase 1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose deprivation.	Oxygen	145-151	glutathione peroxidase 1	Homo sapiens	27-51
26981165-7	2016	These SIRT1 activators also showed moderate protective effects on mitochondrial function in t-BHP cells by recovering oxygen consumption and increasing mitochondrial DNA content.	Oxygen	118-124	sirtuin 1	Homo sapiens	6-11
26579560-2	2015	It has been confirmed that O2 plasma treatment forms a GeSnO(x) film on the surface and the GeSnO(x) topped by in situ Al2O3 constitutes the gate stack of GeSn MOS devices.	Oxygen	27-29	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	160-163
26639784-4	2015	In contrast to the glucose transporter GLUT1, GLUT3 was regulated by environmental oxygen and localised to hESC membranes.	Oxygen	83-89	solute carrier family 2 member 3	Homo sapiens	46-51
26010290-4	2015	The A1R-antagonist, 8-cyclopentyl-1,3-dipropylxanthine (CPX) and adenosine deaminase (ADA), which metabolize endogenous adenosine, reduced O2 consumption (40-50%).	Oxygen	139-141	adenosine deaminase	Homo sapiens	65-84
26375300-6	2015	In addition, cultured cortical neurons treated with the rpS6 kinase (S6K) inhibitors, D-glucosamine or PF4708671, displayed a decrease in rpS6 phosphorylation and a subsequent increase in tolerance to oxygen/glucose deprivation, an in vitro model of ischemic stroke.	Oxygen	201-207	40S ribosomal protein S6	Ictidomys tridecemlineatus	56-60
26542565-3	2015	We conducted oxygen-17 single-crystal nuclear magnetic resonance (NMR) measurements of the spin-1/2 kagome lattice in herbertsmithite [ZnCu3(OH)6Cl2], which is known to exhibit a spinon continuum in the spin excitation spectrum.	Oxygen	13-19	spindlin 1	Homo sapiens	91-97
26468675-2	2015	Quiescin sulfhydryl oxidase (QSOX) is a multidomain catalyst of disulfide-bond formation that relays electrons from substrate cysteines through two redox-active sites to molecular oxygen.	Oxygen	180-186	quiescin sulfhydryl oxidase 1	Homo sapiens	0-27
26468675-2	2015	Quiescin sulfhydryl oxidase (QSOX) is a multidomain catalyst of disulfide-bond formation that relays electrons from substrate cysteines through two redox-active sites to molecular oxygen.	Oxygen	180-186	quiescin sulfhydryl oxidase 1	Homo sapiens	29-33
27251529-5	2015	Here we show that a low-oxygen-responsive universal stress protein (USP), Hypoxia Responsive Universal Stress Protein 1 (HRU1), is induced by RAP2.12 (Related to Apetala 2.12), an ERF-VII protein, and modulates ROS production in Arabidopsis.	Oxygen	24-30	related to AP2 12	Arabidopsis thaliana	142-149
26296884-0	2015	Striking Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.	Oxygen	9-15	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	35-80
26296884-0	2015	Striking Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.	Oxygen	9-15	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	82-85
26362813-1	2015	Neuroglobin (Ngb), a 17 kDa monomeric protein, was initially described as a vertebrate oxygen-binding heme protein in 2000 and detected in metabolically active organs or cells, like the brain, peripheral nervous system as well as certain endocrine cells.	Oxygen	87-93	neuroglobin	Homo sapiens	0-11
26362813-1	2015	Neuroglobin (Ngb), a 17 kDa monomeric protein, was initially described as a vertebrate oxygen-binding heme protein in 2000 and detected in metabolically active organs or cells, like the brain, peripheral nervous system as well as certain endocrine cells.	Oxygen	87-93	neuroglobin	Homo sapiens	13-16
26265081-3	2015	The proposed O2 activation mechanism involves the trapping of a Cr-O2 adduct by Fe(TMC)(OTf)2.	Oxygen	13-15	POU class 2 homeobox 2	Homo sapiens	88-93
26483619-3	2015	Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of immediate adaptation to hypoxia necessary for (1) succinate-related energy synthesis in the conditions of oxygen deficiency and formation of urgent resistance in the body; (2) succinate-related stabilization of HIF-1alpha and initiation of its transcriptional activity related with formation of long-term adaptation; (3) succinate-related activation of the succinate-specific receptor, GPR91.	Oxygen	209-215	succinate receptor 1	Homo sapiens	489-494
25592488-8	2015	At an early stage, one study showed CPAP to reduce respiratory complications and to improve the outcome of mortality rate from 75% in the control group to 15% in the treatment group, when compared to oxygen therapy.	Oxygen	200-206	centromere protein J	Homo sapiens	36-40
26276387-2	2015	If exposed to humid Cl2 gas for 110 min, steel S235 became an electrocatalyst that exhibits an overpotential for the oxygen evolution reaction (OER) of 462 mV at 1 mA cm(-2) at pH 7.	Oxygen	117-123	endogenous retrovirus group W member 5	Homo sapiens	20-23
26328624-8	2015	Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass was reduced by 6.2 and 10.7 % with OM3-CA 2 and 4 g/d, respectively, vs. a 0.1 % increase with OO (p &lt; 0.001 for both vs. OO).	Oxygen	150-152	phospholipase A2 group VII	Homo sapiens	0-39
26328624-8	2015	Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass was reduced by 6.2 and 10.7 % with OM3-CA 2 and 4 g/d, respectively, vs. a 0.1 % increase with OO (p &lt; 0.001 for both vs. OO).	Oxygen	150-152	phospholipase A2 group VII	Homo sapiens	41-48
26328624-8	2015	Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass was reduced by 6.2 and 10.7 % with OM3-CA 2 and 4 g/d, respectively, vs. a 0.1 % increase with OO (p &lt; 0.001 for both vs. OO).	Oxygen	180-182	phospholipase A2 group VII	Homo sapiens	0-39
26328624-8	2015	Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass was reduced by 6.2 and 10.7 % with OM3-CA 2 and 4 g/d, respectively, vs. a 0.1 % increase with OO (p &lt; 0.001 for both vs. OO).	Oxygen	180-182	phospholipase A2 group VII	Homo sapiens	41-48
26150471-4	2015	Surprisingly, the strongest signal was detected in broth medium without bacterial cells present and it was mitigated by iron chelation or by addition of catalase, which catalyzes the decomposition of hydrogen peroxide to water and oxygen.	Oxygen	231-237	AT695_RS10915	Staphylococcus aureus	153-161
26224005-0	2015	Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.	Oxygen	114-120	DND microRNA-mediated repression inhibitor 1	Mus musculus	45-49
26224005-6	2015	In Dnd1 heterozygotes, lower oxygen availability was associated with metabolic differences, including lower levels of ATP and NADH in the left testis.	Oxygen	29-35	DND microRNA-mediated repression inhibitor 1	Mus musculus	3-7
25934335-7	2015	Interestingly, stereotactic implantation of U87-MG cells grown under normoxia or mild hypoxia within the striatum of nude mice led to differential growth; the cells grown under hypoxia retaining an imprint of the oxygen adaptation as their development is then slowed down.	Oxygen	213-219	small nucleolar RNA, C/D box 87	Homo sapiens	44-47
26207342-8	2015	Tyrosinase is a copper-based O2-activating enzyme, whose structure and reactivity have been widely studied, and that serves as a paradigm for O2 activation at a dimetal site.	Oxygen	29-31	tyrosinase	Homo sapiens	0-10
26207342-8	2015	Tyrosinase is a copper-based O2-activating enzyme, whose structure and reactivity have been widely studied, and that serves as a paradigm for O2 activation at a dimetal site.	Oxygen	142-144	tyrosinase	Homo sapiens	0-10
26138361-2	2015	This process allows syn substituents to be established stereospecifically on the 2-carbon bridge connecting the ketone carbonyl carbons, and the formation of one carbon-carbon and two carbon-oxygen bonds.	Oxygen	191-197	synemin	Homo sapiens	20-23
26179900-6	2015	Our results point to a role for IL-10, as suggested by the increased IL-10 expression at low O2 levels and the unchanged IFN-gamma production by IL-10-deficient Th1 cells stimulated in hypoxic conditions.	Oxygen	93-95	interleukin 10	Homo sapiens	32-37
26179900-6	2015	Our results point to a role for IL-10, as suggested by the increased IL-10 expression at low O2 levels and the unchanged IFN-gamma production by IL-10-deficient Th1 cells stimulated in hypoxic conditions.	Oxygen	93-95	interleukin 10	Homo sapiens	69-74
26179900-6	2015	Our results point to a role for IL-10, as suggested by the increased IL-10 expression at low O2 levels and the unchanged IFN-gamma production by IL-10-deficient Th1 cells stimulated in hypoxic conditions.	Oxygen	93-95	interleukin 10	Homo sapiens	69-74
28793504-0	2015	Effect of Annealing Temperature and Oxygen Flow in the Properties of Ion Beam Sputtered SnO-2x Thin Films.	Oxygen	36-42	strawberry notch homolog 2	Homo sapiens	88-91
26266933-8	2015	Notably, mitochondrial function was altered in the fahd-1(tm5005) mutant strain, as shown by a reduction of mitochondrial membrane potential and a reduced oxygen consumption of fahd-1(tm5005) animals.	Oxygen	155-161	Fumarylacetoacetate hydrolase domain-containing protein 1	Caenorhabditis elegans	51-57
26223520-3	2015	We have previously shown that the hypoxia-inducible cellular oxygen sensor PHD3/EGLN3 enhances hypoxic cell cycle entry at the G1/S boundary.	Oxygen	61-67	egl-9 family hypoxia inducible factor 3	Homo sapiens	75-79
26223520-3	2015	We have previously shown that the hypoxia-inducible cellular oxygen sensor PHD3/EGLN3 enhances hypoxic cell cycle entry at the G1/S boundary.	Oxygen	61-67	egl-9 family hypoxia inducible factor 3	Homo sapiens	80-85
26013064-3	2015	Impurities include residual protons and protic compounds that can react with oxygen species, such as the superoxide (O2 (-) ), a reactive, one-electron reduction product of oxygen.	Oxygen	77-83	immunoglobulin kappa variable 1D-39	Homo sapiens	117-123
26013064-3	2015	Impurities include residual protons and protic compounds that can react with oxygen species, such as the superoxide (O2 (-) ), a reactive, one-electron reduction product of oxygen.	Oxygen	173-179	immunoglobulin kappa variable 1D-39	Homo sapiens	117-123
26013064-6	2015	It is shown directly that O2 (-) , not HO2 , is the first stable intermediate during the oxygen reduction process to hydrogen peroxide.	Oxygen	89-95	immunoglobulin kappa variable 1D-39	Homo sapiens	26-32
25824146-3	2015	METHODS AND RESULTS: The level of BMP4 mature protein was increased for ~183% in distal pulmonary arterial smooth muscle (PA) from CH (10% O2 for 21 days; CH) exposed rats, and 143% in PASMCs cultured under prolonged hypoxia (4% O2 for 60 h).	Oxygen	139-141	bone morphogenetic protein 4	Rattus norvegicus	34-38
25824146-3	2015	METHODS AND RESULTS: The level of BMP4 mature protein was increased for ~183% in distal pulmonary arterial smooth muscle (PA) from CH (10% O2 for 21 days; CH) exposed rats, and 143% in PASMCs cultured under prolonged hypoxia (4% O2 for 60 h).	Oxygen	229-231	bone morphogenetic protein 4	Rattus norvegicus	34-38
31973283-1	2015	Benzoxazine-based redox polymers bearing Os complexes are synthesized and used as an immobilization matrix for glucose oxidase (GOx) as a model system for a reagentless biosensor.	Oxygen	41-43	hydroxyacid oxidase 1	Homo sapiens	111-126
31973283-1	2015	Benzoxazine-based redox polymers bearing Os complexes are synthesized and used as an immobilization matrix for glucose oxidase (GOx) as a model system for a reagentless biosensor.	Oxygen	41-43	hydroxyacid oxidase 1	Homo sapiens	128-131
25569611-0	2015	Elimination of influences of the ACTN3 R577X variant on oxygen uptake by endurance training in healthy individuals.	Oxygen	56-62	actinin alpha 3	Homo sapiens	33-38
25569611-1	2015	AIM: To study the relationship between the ACTN3 R577X polymorphism and oxygen uptake (VO2) before and after exercise training.	Oxygen	72-78	actinin alpha 3	Homo sapiens	43-48
25953442-11	2015	CONCLUSIONS: We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC.	Oxygen	84-90	transcription factor AP-2 alpha	Homo sapiens	59-65
26942078-3	2016	In this study, we show that exposure of mouse and human tumor cell lines to hypoxic conditions (1% O2) promotes CD137 transcription.	Oxygen	99-101	TNF receptor superfamily member 9	Homo sapiens	112-117
26106885-5	2015	We report increased basal oxygen consumption in drp-1; reduced maximal respiration in drp-1, fzo-1, and isp-1; reduced spare respiratory capacity in drp-1 and fzo-1; reduced proton leak in fzo-1 and isp-1; and increased proton leak in pink-1 nematodes.	Oxygen	26-32	Dynamin GTPase	Caenorhabditis elegans	48-53
25868151-7	2015	This approach was illustrated and validated by measuring mRNA levels including Vegf-a in newborn mouse lungs that were injured by 85% oxygen (hyperoxia) for 12 days and compared with control (normoxia).	Oxygen	134-140	vascular endothelial growth factor A	Mus musculus	79-85
26194081-6	2015	In addition, GLP-1 increased the mitochondrial membrane potential and oxygen consumption.	Oxygen	70-76	glucagon	Rattus norvegicus	13-18
25671767-4	2015	We have recently identified the SAM-domain containing protein Anks3 as a potential ANKS6/NPHP16-interacting protein, and report now that Anks3 interacts with several NPHPs as well as with Bicc1 and the oxygen-sensitive asparaginyl hydroxylase HIF1AN.	Oxygen	202-208	ankyrin repeat and sterile alpha motif domain containing 6	Danio rerio	83-88
25847219-0	2015	The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3.	Oxygen	8-14	related to AP2 12	Arabidopsis thaliana	122-129
25847219-0	2015	The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3.	Oxygen	8-14	related to AP2 2	Arabidopsis thaliana	131-137
25847219-6	2015	Oxygen-dependent degradation of RAP2.12 was previously shown to be mediated by the N-end rule pathway.	Oxygen	0-6	related to AP2 12	Arabidopsis thaliana	32-39
25702874-4	2015	We show that preincubation for 2 days or more in 1% oxygen reduces serum deprivation-mediated cell death, as observed by higher cell numbers and lower incorporation of EthD-III and Annexin V.	Oxygen	52-58	annexin A5	Mus musculus	181-190
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Oxygen	53-59	polo like kinase 1	Homo sapiens	78-82
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Oxygen	53-59	polo like kinase 1	Homo sapiens	208-212
25943704-4	2015	The cyclic voltammetry of immobilized GOx showed a pair of well-defined redox peaks in O2-free solution, indicating the DET of GOx.	Oxygen	87-89	hydroxyacid oxidase 1	Homo sapiens	38-41
25943704-4	2015	The cyclic voltammetry of immobilized GOx showed a pair of well-defined redox peaks in O2-free solution, indicating the DET of GOx.	Oxygen	87-89	hydroxyacid oxidase 1	Homo sapiens	127-130
25780855-0	2015	Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach.	Oxygen	62-68	actin-binding Rho activating protein	Rattus norvegicus	127-130
25780855-2	2015	Here we employed a reproducible ion-current-based MS1 quantification approach (ICB) to explore the retinal proteomic changes in early stage of ROP in a rat model of oxygen-induced retinopathy (OIR).	Oxygen	165-171	actin-binding Rho activating protein	Rattus norvegicus	50-53
25995618-0	2015	The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.	Oxygen	61-67	vascular endothelial growth factor A	Mus musculus	105-109
26406492-1	2015	RATIONALE: The separation and purification of oxygen-argon mixtures are critical in the high-precision analysis of Delta(17) O and delta(O2 /Ar) for geochemical applications.	Oxygen	46-52	immunoglobulin kappa variable 1D-39	Homo sapiens	131-139
25798528-3	2015	Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom.	Oxygen	141-147	RNA polymerase III subunit K	Homo sapiens	120-124
25740828-6	2015	In addition, in both the murine model and human leukemia cells, we found that Meis1 loss led to increased oxidative stress, oxygen flux, and apoptosis.	Oxygen	124-130	Meis homeobox 1	Homo sapiens	78-83
25880095-6	2015	This was verified when aASCs that were grown under 3% oxygen conditions expanded long term, displaying reduced NOX1 expression and decreased ROS accumulation.	Oxygen	54-60	NADPH oxidase 1	Rattus norvegicus	111-115
25846796-0	2015	Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.	Oxygen	0-6	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	72-87
25846796-3	2015	Here, we generated mice with either single or combined genetic inactivation of the critical oxygen-sensing prolyl hydroxylase (PHD) enzymes (PHD1-3) in osteoprogenitors.	Oxygen	92-98	egl-9 family hypoxia-inducible factor 2	Mus musculus	141-147
27308509-3	2015	Here, we discuss our recent findings that regulation of hypoxia inducible gene domain family member 1 A (HIGD1A) via epigenetic mechanisms during glucose starvation modulates oxygen consumption and reactive oxygen species production to enable tumor cell survival through the activation of dormancy mechanisms.	Oxygen	175-181	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	105-111
25646298-4	2015	We report here that compared with wild-type littermates, MKL1/MRTF-A knockout mice were more resistant to the development of hypoxia-induced pulmonary hypertension when exposed to low oxygen pressure.	Oxygen	184-190	myocardin related transcription factor A	Mus musculus	57-61
25646298-4	2015	We report here that compared with wild-type littermates, MKL1/MRTF-A knockout mice were more resistant to the development of hypoxia-induced pulmonary hypertension when exposed to low oxygen pressure.	Oxygen	184-190	myocardin related transcription factor A	Mus musculus	62-68
25598140-5	2015	Here, we find that in an in vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is pathological activation of the calcium/calmodulin-dependent protein kinase kinase beta (CaMKKbeta)-AMPKalpha1 signalling pathway.	Oxygen	76-82	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	155-210
25598140-5	2015	Here, we find that in an in vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is pathological activation of the calcium/calmodulin-dependent protein kinase kinase beta (CaMKKbeta)-AMPKalpha1 signalling pathway.	Oxygen	76-82	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	212-221
25598140-8	2015	We show that in an in vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is a pathological activation of the CaMKKbeta-AMPKalpha1 signalling pathway.	Oxygen	70-76	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	151-160
25753154-3	2015	Previously, BF2 dbm(I)PLA was proven to be a good oxygen nanosensor material for tumor hypoxia imaging in vivo, though particles were applied directly to the tumor and surrounding region.	Oxygen	50-56	forkhead box D1	Mus musculus	12-15
25781899-3	2015	In the present study, we found that knockdown of Mfn2 by shRNA led to impaired autophagic degradation, inhibited mitochondrial oxygen consumption rate and cell glycolysis, reduced ATP production, and suppressed cell proliferation.	Oxygen	127-133	mitofusin 2	Homo sapiens	49-53
25550320-3	2015	Due to oxygen deficiency, mammalian cells activate the transcriptional factor hypoxia-inducible factor (HIF); its degradation is regulated by prolyl hydroxylase 3 (PHD3) in interaction with the scaffold protein MAPK organizer 1 (Morg1).	Oxygen	7-13	egl-9 family hypoxia inducible factor 3	Homo sapiens	142-162
25550320-3	2015	Due to oxygen deficiency, mammalian cells activate the transcriptional factor hypoxia-inducible factor (HIF); its degradation is regulated by prolyl hydroxylase 3 (PHD3) in interaction with the scaffold protein MAPK organizer 1 (Morg1).	Oxygen	7-13	egl-9 family hypoxia inducible factor 3	Homo sapiens	164-168
25657114-0	2015	Protosappanin B protects PC12 cells against oxygen-glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation.	Oxygen	44-50	polypyrimidine tract binding protein 1	Rattus norvegicus	0-15
25621374-12	2015	TGF-beta2 downregulation via siRNA abrogated the hypoxia-induced COL2 expression, as did ALK5 inhibition, giving a strong indication that this pathway is involved in chondrocyte redifferentiation under low oxygen tension.	Oxygen	206-212	transforming growth factor beta 2	Homo sapiens	0-9
25490569-7	2015	The hydrogen uptake of Pd/AC-ox1 at RT and 8 MPa with an oxygen content of 8.94 wt.% was 0.37 wt.%, which was 48% greater than that of Pd-free AC-ox (0.25 wt.%).	Oxygen	57-63	acyl-CoA oxidase 1	Homo sapiens	26-32
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	44-50	secernin 1	Bos taurus	61-64
25462805-1	2015	An accurate determination of myoglobin (Mb) oxygen affinity (P50) can be difficult due to hemoglobin (Hb) contamination and autoxidation of Mb to metMb which is incapable of binding oxygen.	Oxygen	182-188	secernin 1	Bos taurus	61-64
25462805-3	2015	However, the temperature dependent shift in Mb oxygen affinity results in a greater oxygen affinity (lower P50) at colder temperatures than occurs at physiological temperature (ca.	Oxygen	47-53	secernin 1	Bos taurus	107-110
25462805-3	2015	However, the temperature dependent shift in Mb oxygen affinity results in a greater oxygen affinity (lower P50) at colder temperatures than occurs at physiological temperature (ca.	Oxygen	84-90	secernin 1	Bos taurus	107-110
25714339-1	2015	One way that aerobic biological systems counteract the generation of reactive oxygen species (ROS) is with superoxide dismutase proteins SOD1 and SOD2 that metabolize superoxide radicals to molecular oxygen and hydrogen peroxide or scavenge oxygen radicals produced by the extensive oxidation-reduction and electron-transport reactions that occur in mitochondria.	Oxygen	78-84	Mn superoxide dismutase	Bombyx mori	146-150
25683712-0	2015	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.	Oxygen	17-23	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	0-6
25548283-5	2015	Furthermore, MCU knockdown lowered the expression of respiratory chain complexes, mitochondrial metabolic activity, and oxygen consumption.	Oxygen	120-126	mitochondrial calcium uniporter	Rattus norvegicus	13-16
25465055-2	2015	NOX2 being a multi-enzyme component is activated during host defense in phagocytes such as microglia, to catalyze the production of superoxide from oxygen, while ROCK is an important mediator of fundamental cell processes like adhesion, proliferation and migration.	Oxygen	148-154	cytochrome b-245 beta chain	Homo sapiens	0-4
25632145-2	2015	We report here that deficiency in bax exerted broad neuroprotection against excitotoxic injury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, necrotic injury, and cerebral edema formation after middle cerebral artery occlusion in mice.	Oxygen	99-105	BCL2-associated X protein	Mus musculus	34-37
25632183-2	2015	METHODS: In this study, we correlated hypoxia inducible factor (HIF)-1alpha expression to the perfusion temperature and the hepatic oxygen uptake in a model of isolated perfused rat liver.	Oxygen	132-138	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	38-75
25722905-0	2015	Hyperbaric oxygen therapy in branch retinal artery occlusion in a 15-year-old boy with methylenetetrahydrofolate reductase mutation.	Oxygen	11-17	methylenetetrahydrofolate reductase	Homo sapiens	87-122
26315049-14	2015	CONCLUSION: Taken together, these results suggest that CD38 activity is required for 7-Ket-induced Ca2+ and consequently O2-.	Oxygen	121-123	CD38 antigen	Mus musculus	55-59
26278717-1	2015	BACKGROUND/AIMS: HIF-1alpha is accumulated in the cellular nucleus and cytoplasm under conditions of oxygen deprivation and engaged in pathophysiologic changes of homeostasis by modulating the expression of several target genes.	Oxygen	101-107	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	17-27
25832023-10	2015	Because H2O2 levels varied among the drugs, we conclude that the proton network in the distal pocket of CYP2C19 is perturbed differently by different drugs, and activated oxygen is degraded to become H2O2.	Oxygen	171-177	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	104-111
25300959-7	2015	Single visual stimulation shows positive blood-oxygen-level-dependent (BOLD) responses (PBR) in the primary and associative visual cortices.	Oxygen	47-53	translocator protein	Homo sapiens	88-91
26317897-0	2015	Hyperbaric oxygen therapy palliates lipopolysaccharide-induced acute lung injury in rats by upregulating AQP1 and AQP5 expression.	Oxygen	11-17	aquaporin 5	Rattus norvegicus	114-118
26118715-7	2015	This was associated with a decrease in mitochondrial oxygen consumption rate and intracellular ATP level in adipocytes with Mfrn1/2 knockdown.	Oxygen	53-59	solute carrier family 25 member 37	Homo sapiens	124-131
24762865-6	2015	Significant improvements were found in cell density, rate of apoptosis, oxidative stress markers, FasL, and caspases in rats treated with hyperbaric oxygen within 72 hours compared to hypoxic-ischemic injury.	Oxygen	149-155	caspase 8	Rattus norvegicus	108-116
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	86-88	vascular endothelial growth factor A	Mus musculus	29-33
26836820-9	2015	RESULTS: HIF-1alpha mRNA and VEGF protein were significantly downregulated in the 50% O2 group; VEGF mRNA and protein were significantly downregulated in the 12% O2-50% O2 group; Ang-1 and its receptor mRNA expression were downregulated in 12% O2 and 12% O2-50% O2 groups.	Oxygen	162-164	vascular endothelial growth factor A	Mus musculus	96-100
25617395-1	2015	Methemoglobin (MetHb) is a form of hemoglobin in which heme iron is oxidized and unable to bind oxygen; its normal basal production is counteracted by an efficient MetHb-reduction pathway.	Oxygen	96-102	hemoglobin subunit gamma 2	Homo sapiens	0-13
25617395-1	2015	Methemoglobin (MetHb) is a form of hemoglobin in which heme iron is oxidized and unable to bind oxygen; its normal basal production is counteracted by an efficient MetHb-reduction pathway.	Oxygen	96-102	hemoglobin subunit gamma 2	Homo sapiens	15-20
25617395-7	2015	This case emphasizes causes of methemoglobinemia and differences among analytical methods used to measure oxygen status when MetHb is present.	Oxygen	106-112	hemoglobin subunit gamma 2	Homo sapiens	125-130
25575809-6	2015	Ectopic expression of GRIM-19 in HNSCC cells led to increased oxygen consumption, reduced glycolysis and decreased cell proliferation.	Oxygen	62-68	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	22-29
25575809-8	2015	Moreover, GRIM-19 knockdown not only resulted in decreased oxygen consumption and increased aerobic glycolysis but also promoted cell proliferation and tumorigenic capacity in HNSCC cells.	Oxygen	59-65	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	10-17
26265981-6	2015	Oxygen/O3 dose-dependently increased the expression of the antioxidant enzymes Mn-SOD and GPx1 and of eNOS compared to the exercised O2 rats.	Oxygen	0-6	superoxide dismutase 2	Rattus norvegicus	79-85
25549101-7	2014	In starvation-stressed TBP/Q36 and TBP/Q79 cells, increased reactive oxygen species generation accelerated the cytoplasmic translocation of HMGB1, which accompanied autophagy activation.	Oxygen	69-75	TATA-box binding protein	Homo sapiens	23-26
25549101-7	2014	In starvation-stressed TBP/Q36 and TBP/Q79 cells, increased reactive oxygen species generation accelerated the cytoplasmic translocation of HMGB1, which accompanied autophagy activation.	Oxygen	69-75	TATA-box binding protein	Homo sapiens	35-38
25104852-10	2014	Taken together, the results support the hypothesis that reduced expression of frataxin leads to elevation of COX2-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species.	Oxygen	226-232	frataxin	Mus musculus	78-86
25263880-4	2014	MDG-1 could evoked weight loss and reduce adipose tissue mass (by up to ~ 50%) in the obese animals by increasing oxygen consumption and energy expenditure without inhibiting appetite or increasing physical activity.	Oxygen	114-120	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
25503457-0	2014	Protective effects of beta1/2 adrenergic receptor deletion in a model of oxygen-induced retinopathy.	Oxygen	73-79	adrenergic receptor, beta 1	Mus musculus	22-49
25385837-7	2014	Therefore, in the normal sympathoadrenal setting, Vhl deletion does not give rise to tumors but impairs development and plasticity of the peripheral O2-sensing system required for survival in hypoxic conditions.	Oxygen	149-151	von Hippel-Lindau tumor suppressor	Mus musculus	50-53
25293376-9	2014	Low oxygen supply upregulated CXCR4, CCR7 and CXCR6, but downregulated CXCL12 and CCR1.	Oxygen	4-10	C-X-C motif chemokine receptor 4	Homo sapiens	30-35
25538908-12	2014	In summary, before the therapeutic application of MSCs, it should be regarded as a necessity to optimize the oxygen concentration in these cells, as it is a critical factor in modulating CXCR4 expression.	Oxygen	109-115	chemokine (C-X-C motif) receptor 4	Mus musculus	187-192
25431923-0	2014	Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	45-52
25431923-1	2014	Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-alpha inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1alpha, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	55-97
25431923-1	2014	Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-alpha inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1alpha, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).	Oxygen	8-14	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	99-106
25230572-5	2014	XPS analyses, in agreement with TPR measurements, demonstrated an increase of superficial oxygen vacancies, the variation being much more pronounced in the La0.6Sr0.4Co0.8Fe0.17Pd0.03O3-delta sample.	Oxygen	90-96	translocated promoter region, nuclear basket protein	Homo sapiens	32-35
25445587-8	2014	RT-PCR analysis of hepatocytes cultured under the oxygen gradient showed that mRNA expression of PEPCK and GK significantly increased in culture areas corresponding to PP and PC regions, respectively.	Oxygen	50-56	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	97-102
25270331-9	2014	These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.	Oxygen	159-165	group XIIA secretory phospholipase A2	Sus scrofa	21-29
24753448-6	2014	In chick embryos, oxygen deprivation simultaneously activated NA-LC while deactivating H/O-producing neurons; it also increased cFos expression in the Pallium.	Oxygen	18-24	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-132
25119431-2	2014	Syn adducts emerge with regard to the vicinal nitrogen and oxygen heteroatom substituents.	Oxygen	59-65	synemin	Homo sapiens	0-3
24751692-1	2014	The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress.	Oxygen	200-206	metal-regulatory transcription factor 1	Danio rerio	4-59
24751692-1	2014	The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress.	Oxygen	200-206	metal-regulatory transcription factor 1	Danio rerio	61-66
25279404-3	2014	While several enzymes and metabolic processes can generate intracellular reactive oxygen species in the brain, recently an O2--generating enzyme, NADPH oxidase 2 (Nox2), has emerged as a major source of oxidative stress in ageing-related vascular endothelial dysfunction and neurodegenerative diseases.	Oxygen	123-125	cytochrome b-245 beta chain	Homo sapiens	146-161
25279404-3	2014	While several enzymes and metabolic processes can generate intracellular reactive oxygen species in the brain, recently an O2--generating enzyme, NADPH oxidase 2 (Nox2), has emerged as a major source of oxidative stress in ageing-related vascular endothelial dysfunction and neurodegenerative diseases.	Oxygen	123-125	cytochrome b-245 beta chain	Homo sapiens	163-167
24962727-0	2014	Platinum and palladium nanotubes based on genetically engineered elastin-mimetic fusion protein-fiber templates: synthesis and application in lithium-O2 batteries.	Oxygen	150-152	elastin	Homo sapiens	65-72
25309795-0	2014	Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells.	Oxygen	40-46	heme oxygenase 1	Rattus norvegicus	32-36
25320455-6	2014	Concerning another source of O2 ( -), the phagocyte NADPH oxidase (Nox2), shikonin inhibited the Nox2 activity by impairing catalysis when added before enzyme activation (IC50: 1.1 microM; NADPH oxidation assay).	Oxygen	29-31	cytochrome b-245 beta chain	Homo sapiens	67-71
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	71-76	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-7
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	71-76	nuclear receptor subfamily 1 group I member 3	Homo sapiens	19-22
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	71-76	nuclear receptor subfamily 1 group I member 3	Homo sapiens	19-22
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	71-76	nuclear receptor subfamily 1 group I member 3	Homo sapiens	19-22
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	92-97	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-7
24939615-2	2014	The CAR in the PhA/CAR micelles significantly diminished PhA-generated (1)O2 through direct (1)O2 scavenging, whereas the CAR molecules lost their (1)O2 scavenging activity when the PhA and CAR were spatially isolated by the disintegration of the PEG-b-PCL micelles.	Oxygen	92-97	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-7
25161929-12	2014	In all oxygen treated groups VEGF mRNA expression was significantly increased as compared to age-matched controls.	Oxygen	7-13	vascular endothelial growth factor A	Mus musculus	29-33
25239873-4	2014	hNAG-1 mice displayed significantly reduced body and adipose tissue weight, lowered serum IGF-1, insulin and glucose levels, improved insulin sensitivity, and increased oxygen utilization, oxidative metabolism and energy expenditure.	Oxygen	169-175	growth differentiation factor 15	Homo sapiens	0-6
24856106-5	2014	The cell-binding activity of bound tropoelastin was modulated by ion implantation of the underlying polymer, and correlated with surface hydrophobicity, carbon and oxygen content.	Oxygen	164-170	elastin	Homo sapiens	35-47
24950091-4	2014	The specific oxygen uptake rates (SOUR) of the granules followed SI&gt;SS&gt;SA&gt;SAA&gt;SW&gt;SF; and the corresponding granular strengths (10 min ultrasound) followed SI&gt;SA=SS&gt;SAA&gt;SW&gt;&gt;SF.	Oxygen	13-19	serum amyloid A1 cluster	Homo sapiens	83-86
24518876-8	2014	Down-regulation of Mfn2 with siRNA in 293T cells induced significant mitochondrial dysfunction including decreased oxygen consumption, decreased ATP production, and increased ROS production, followed by increased triglyceride content suggesting a contributing role of decreased mitochondrial fusion to lipid deposit.	Oxygen	115-121	mitofusin 2	Homo sapiens	19-23
24777310-4	2014	Herein, we show that a panel of continuously growing mouse mesenchymal stromal cell lines, namely OP9, MS5, PA6, ST2 and B16-14, exhibit mesenchymal stromal cell characteristic phenotypes and respond physiologically to oxygen deprivation.	Oxygen	219-225	minisatellites detected by probe MMS5	Mus musculus	103-106
24777310-4	2014	Herein, we show that a panel of continuously growing mouse mesenchymal stromal cell lines, namely OP9, MS5, PA6, ST2 and B16-14, exhibit mesenchymal stromal cell characteristic phenotypes and respond physiologically to oxygen deprivation.	Oxygen	219-225	interleukin 1 receptor-like 1	Mus musculus	113-116
24769160-8	2014	The antiapoptotic effect of GPR3 was also observed under hypoxic (1% O2/5% CO2) and reactive oxygen species (ROS)-induced apoptotic conditions.	Oxygen	69-71	G-protein coupled receptor 3	Mus musculus	28-32
25081069-7	2014	In silico analysis identified four oxygen-sensitive miRNAs whose seed regions perfectly matched the 3"-UTR of NDRG1.	Oxygen	35-41	N-myc downstream regulated 1	Homo sapiens	110-115
25081069-10	2014	Our results revealed that miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration.	Oxygen	87-93	N-myc downstream regulated 1	Homo sapiens	63-68
24535698-7	2014	PaO2 (partial pressure of oxygen in arterial blood) was improved by administering bFGF-GMS in the total emphysema model (p = 0.027).	Oxygen	26-32	fibroblast growth factor 2	Canis lupus familiaris	82-86
27366424-3	2014	Methemoglobinemia is a serious clinical condition, associated with increased blood methemoglobin levels characterized by clinical signs, such as cyanosis and hypoxia due to lack of oxygen-carrying capacity.	Oxygen	181-187	hemoglobin subunit gamma 2	Homo sapiens	83-96
24359107-1	2014	SIGNIFICANCE: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide.	Oxygen	129-135	quiescin sulfhydryl oxidase 1	Homo sapiens	23-43
24359107-1	2014	SIGNIFICANCE: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide.	Oxygen	129-135	quiescin sulfhydryl oxidase 1	Homo sapiens	45-50
24787051-11	2014	As TGFbeta2 secretion from anchoring villi is down-regulated in low oxygen, these findings suggest that the low oxygen environment in early pregnancy may be important to allow EVT outgrowth expansion and promote adequate placentation.	Oxygen	68-74	transforming growth factor beta 2	Homo sapiens	3-11
24787051-11	2014	As TGFbeta2 secretion from anchoring villi is down-regulated in low oxygen, these findings suggest that the low oxygen environment in early pregnancy may be important to allow EVT outgrowth expansion and promote adequate placentation.	Oxygen	112-118	transforming growth factor beta 2	Homo sapiens	3-11
24880746-2	2014	NADPH oxidase (Nox) 2 and 4 are the major sources of O2- and H2O2 in the heart and play a crucial role in the regulation of growth and death in cardiomyocytes.	Oxygen	53-55	cytochrome b-245 beta chain	Homo sapiens	0-27
24861078-12	2014	HIF-1alpha is up-regulated which is associated with increased oxygen demand and angiogenesis.	Oxygen	62-68	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
24442237-4	2014	The HepG2 cells were cultured in 21% O2 (normoxia) or 1% O2 (hypoxia) for 24 h. The release of netrin-1 from hypoxic cells was detected by ELISA.	Oxygen	57-59	netrin 1	Homo sapiens	95-103
24595825-2	2014	About 30-40 % of these tumours are mutated in one of the different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in the tricarboxylic acid cycle and in the oxygen transport chain.	Oxygen	236-242	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	144-167
24872551-5	2014	In cultured primary neurons, increasing TIGAR expression reduced oxygen and glucose deprivation (OGD)/reoxygenation-induced injury, whereas decreasing its expression worsened the injury.	Oxygen	65-71	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	40-45
24668807-3	2014	BCO1 has been thought to be a monooxygenase, incorporating oxygen from O2 and H2O into its cleavage products.	Oxygen	34-40	beta-carotene oxygenase 1	Homo sapiens	0-4
24668807-3	2014	BCO1 has been thought to be a monooxygenase, incorporating oxygen from O2 and H2O into its cleavage products.	Oxygen	71-73	beta-carotene oxygenase 1	Homo sapiens	0-4
24668807-7	2014	Together with the data from (18)O-retinal-H2(16)O and (16)O-retinal-H2(18)O incubations to account for nonenzymatic oxygen exchange, our results show that BCO1 incorporates only oxygen from O2 into retinal.	Oxygen	116-122	beta-carotene oxygenase 1	Homo sapiens	155-159
24668807-7	2014	Together with the data from (18)O-retinal-H2(16)O and (16)O-retinal-H2(18)O incubations to account for nonenzymatic oxygen exchange, our results show that BCO1 incorporates only oxygen from O2 into retinal.	Oxygen	178-184	beta-carotene oxygenase 1	Homo sapiens	155-159
24668807-7	2014	Together with the data from (18)O-retinal-H2(16)O and (16)O-retinal-H2(18)O incubations to account for nonenzymatic oxygen exchange, our results show that BCO1 incorporates only oxygen from O2 into retinal.	Oxygen	190-192	beta-carotene oxygenase 1	Homo sapiens	155-159
24788190-8	2014	Western blot analysis revealed that low oxygen enhanced beta-tubulin III and GFAP expression in both cultures.	Oxygen	40-46	glial fibrillary acidic protein	Homo sapiens	77-81
24519666-4	2014	Because of the strong link between ratings of perceived exertion (RPE) and oxygen uptake (V O2), it has been proposed that the individual relationship between RPE and V O2 (RPE:V O2) can be used to predict V O2 max (or V O2 peak) from data measured during submaximal exercise tests.	Oxygen	75-81	ribulose-5-phosphate-3-epimerase	Homo sapiens	66-69
24519666-4	2014	Because of the strong link between ratings of perceived exertion (RPE) and oxygen uptake (V O2), it has been proposed that the individual relationship between RPE and V O2 (RPE:V O2) can be used to predict V O2 max (or V O2 peak) from data measured during submaximal exercise tests.	Oxygen	75-81	ribulose-5-phosphate-3-epimerase	Homo sapiens	159-181
24642336-0	2014	CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.	Oxygen	52-58	protein tyrosine phosphatase receptor type C	Homo sapiens	6-10
24642336-0	2014	CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.	Oxygen	74-80	protein tyrosine phosphatase receptor type C	Homo sapiens	6-10
24569591-8	2014	For follicles cultured at 2.5% O2, a 7.2-fold upregulation of Vegfa correlated to an 18-fold increase in VEGFA levels, and a 3.2-fold upregulation of Ldha correlated to a 4.8-fold increase in lactate levels.	Oxygen	31-33	vascular endothelial growth factor A	Mus musculus	62-67
24569591-9	2014	Both VEGFA and lactate levels were significantly higher in follicles cultured at 2.5% compared with 20% O2.	Oxygen	104-106	vascular endothelial growth factor A	Mus musculus	5-10
24656803-6	2014	The resting state of the enzyme is met-tyrosinase [Cu(II)2] and activation, associated with a "lag period", involves reduction to deoxy-tyrosinase [Cu(I)2] which is capable of binding dioxygen to form oxy-tyrosinase [Cu(II)2 O2].	Oxygen	184-192	tyrosinase	Homo sapiens	39-49
24656803-6	2014	The resting state of the enzyme is met-tyrosinase [Cu(II)2] and activation, associated with a "lag period", involves reduction to deoxy-tyrosinase [Cu(I)2] which is capable of binding dioxygen to form oxy-tyrosinase [Cu(II)2 O2].	Oxygen	184-192	tyrosinase	Homo sapiens	136-146
24656803-6	2014	The resting state of the enzyme is met-tyrosinase [Cu(II)2] and activation, associated with a "lag period", involves reduction to deoxy-tyrosinase [Cu(I)2] which is capable of binding dioxygen to form oxy-tyrosinase [Cu(II)2 O2].	Oxygen	184-192	tyrosinase	Homo sapiens	136-146
24699645-0	2014	The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity.	Oxygen	116-122	neuroglobin	Homo sapiens	47-58
24699645-1	2014	Neuroglobin plays an important function in the supply of oxygen in nervous tissues.	Oxygen	57-63	neuroglobin	Homo sapiens	0-11
24508125-1	2014	Prolyl hydroxylase domain (PHD) proteins catalyze oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor 1alpha and 2alpha, tagging them for pVHL-dependent polyubiquitination and proteasomal degradation.	Oxygen	50-56	von Hippel-Lindau tumor suppressor	Mus musculus	152-156
24345704-0	2014	Supplemental oxygen reverses hypoxia-induced smooth muscle cell proliferation by modulating HIF-alpha and VEGF levels in a rabbit arteriovenous fistula model.	Oxygen	13-19	vascular endothelial growth factor A	Oryctolagus cuniculus	106-110
24345704-3	2014	We hypothesize that HIF and VEGF will be downregulated with supplemental oxygen in our arteriovenous fistula rabbit model.	Oxygen	73-79	vascular endothelial growth factor A	Oryctolagus cuniculus	28-32
24345704-10	2014	Plasma VEGF levels in the surgery and supplemental oxygen group were significantly lower than the normoxic surgery group with almost a 45% reduction in plasma VEGF levels (524 pg/mL).	Oxygen	51-57	vascular endothelial growth factor A	Oryctolagus cuniculus	7-11
24345704-10	2014	Plasma VEGF levels in the surgery and supplemental oxygen group were significantly lower than the normoxic surgery group with almost a 45% reduction in plasma VEGF levels (524 pg/mL).	Oxygen	51-57	vascular endothelial growth factor A	Oryctolagus cuniculus	159-163
24345704-13	2014	CONCLUSIONS: Our results suggest that short-term administration of supplemental oxygen inhibits HIFs and VEGF signaling to reduce smooth muscle proliferation in the local blood vessel.	Oxygen	80-86	vascular endothelial growth factor A	Oryctolagus cuniculus	105-109
25004828-8	2014	CRH also up-regulates IL-18 expression by increasing intracellular reactive oxygen in microglia cells.	Oxygen	76-82	interleukin 18	Homo sapiens	22-27
24753139-6	2014	Only in retina cells, mammalian Ngb may help to sustain O2 supply to mitochondria, thereby supporting the visual process in the eye.	Oxygen	56-58	neuroglobin	Homo sapiens	32-35
24734702-5	2014	H2-TPR study revealed the oxygen storage capacity of the catalyst.	Oxygen	26-32	translocated promoter region, nuclear basket protein	Homo sapiens	3-6
24484058-7	2014	For TNT, RDX, and BP, product ions with different reduced mobility values (K0) were observed with CO3(-)(H2O)n and O2(-)(H2O)n, respectively, which is a benefit for the accurate identification.	Oxygen	115-117	radixin	Homo sapiens	9-12
24462831-5	2014	Separately, in human PAECs exposed for 24h to normoxia vs. hypoxia (1-3% O2), ELISA of extracellular media showed increased BDNF levels.	Oxygen	73-75	brain derived neurotrophic factor	Homo sapiens	124-128
24745224-17	2014	The population analysis of the substrate AA shows that a non-negligible difference exists between the attacking oxygens of AA in class I (syn) and in class II (anti) which is one reason for the lower value of delta(q) in class II relative to class I.	Oxygen	112-119	synemin	Homo sapiens	138-141
24556690-4	2014	Using an oxygen-induced retinopathy (OIR) mouse model for ROP, we have previously shown that deletion of the arginase 2 (A2) significantly reduced neuro-glial injury and improved retinal function.	Oxygen	9-15	arginase 2	Homo sapiens	109-119
24754982-8	2014	CONCLUSION: CPAP significantly improves nocturnal oxygen desaturation, sleep architecture and objective sleepiness in patients with severe OSAS.	Oxygen	50-56	centromere protein J	Homo sapiens	12-16
23873717-13	2014	Therefore, disturbed iron and oxygen metabolism in neonatal life may have important effects on skeletal function and structure through FGF23 activity on phosphate regulation.	Oxygen	30-36	fibroblast growth factor 23	Mus musculus	135-140
24103013-6	2014	However, under the same oxygen tension, the mRNA abundance of IFNT of RDCM groups was higher than that of the mSOF groups.	Oxygen	24-30	interferon-tau 3g	Bos taurus	62-66
24739646-7	2014	CONCLUSIONS: The expression of miR-155 and HIF-1alpha is topically stimulated by oxygen signal.HIF-1alpha adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.	Oxygen	81-87	microRNA 155	Homo sapiens	31-38
24478626-4	2014	Thus alterations of oxygen responsive HIF-1alpha subunit in the central nervous system may contribute to the cognitive decline, especially influencing mechanisms associated to amyloid precursor protein (APP) amyloidogenic metabolism.	Oxygen	20-26	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	38-48
25594006-5	2014	Gene ontology enrichment showed that many proteins are involved in response to hypoxia/oxygen levels and positive regulation of the VEGFR signaling pathway.	Oxygen	87-93	kinase insert domain receptor	Homo sapiens	132-137
23962064-8	2014	In experimental O2-induced arrested alveolar growth in newborn rats, the characteristic features of air space enlargement and loss of lung capillaries were associated with decreased lung HIF-1alpha and HIF-2alpha expression.	Oxygen	16-18	endothelial PAS domain protein 1	Rattus norvegicus	202-212
24220759-4	2014	The product, NADPH, triggers the hydroxylation of p-hydroxybenzoate by HBH in the presence of oxygen to produce 3,4-dihydroxybenzoate, which results in a change in electron concentration at the working carbon electrode, which is detected by the potentiostat.	Oxygen	94-100	2,4-dienoyl-CoA reductase 1	Homo sapiens	13-18
24240701-1	2014	SIRT1 is an NAD(+)-dependent protein deacetylase induced by metabolic stresses, such as nutrition or oxygen deprivation.	Oxygen	101-107	sirtuin 1	Homo sapiens	0-5
24584094-0	2014	WIP1 and senescence: oxygen matters.	Oxygen	21-27	protein phosphatase, Mg2+/Mn2+ dependent 1D	Homo sapiens	0-4
25485495-4	2014	We demonstrated that the interference with cell metabolism (oxygen/glucose shortage) enriches cells exhibiting the leukemia stem cell (LSC) phenotype and, at the same time, suppresses BCR/Abl protein expression.	Oxygen	60-66	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	184-191
25535647-6	2014	Our results demonstrated that hypoxic stress induced by exposure of lower O(2) (6 h) significantly increased the levels of HIF-1alpha and VEGF in the oxidative and glycolytic muscles of SD rats and pikas (P&lt;0.05 vs. normoxic conditions).	Oxygen	74-78	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	123-133
25462069-5	2014	As compared to control cells, knockdown of PRX3 expression increased mitochondrial membrane potential, basal ATP production, oxygen consumption and extracellular acidification rates.	Oxygen	125-131	peroxiredoxin 3	Homo sapiens	43-47
23835222-2	2013	Nevertheless, GOx activity is highly oxygen dependent which can lead to inaccuracies in amperometric beta-D-glucose determinations.	Oxygen	37-43	hydroxyacid oxidase 1	Homo sapiens	14-17
24316858-10	2013	The genes that were up regulated in the oxygen carriers cluster (12 genes) were: Hbq1, Mb, Ngb, Slc38a1 and Xirp1.	Oxygen	40-46	hemoglobin, theta 1A	Mus musculus	81-85
23402373-8	2013	HBP concentrations were correlated with the lowest ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen (PF ratio) during the ICU stay (rho = -0.321, p &lt;0.05).	Oxygen	80-86	azurocidin 1	Homo sapiens	0-3
23402373-8	2013	HBP concentrations were correlated with the lowest ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen (PF ratio) during the ICU stay (rho = -0.321, p &lt;0.05).	Oxygen	129-135	azurocidin 1	Homo sapiens	0-3
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Oxygen	245-251	apolipoprotein A-I	Salmo salar	160-165
23954421-8	2013	Intergenic comparison revealed NDM-1 might have greater drug profile and catalytic efficiency than IMP-1 and VIM-2 due to largest pocket opening and least distance between the Zn-I ion and beta-lactam oxygen of meropenem.	Oxygen	201-207	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	99-104
23954421-8	2013	Intergenic comparison revealed NDM-1 might have greater drug profile and catalytic efficiency than IMP-1 and VIM-2 due to largest pocket opening and least distance between the Zn-I ion and beta-lactam oxygen of meropenem.	Oxygen	201-207	vimentin 2, pseudogene	Homo sapiens	109-114
24121716-0	2013	Hydrogen peroxide produced by glucose oxidase affects the performance of laccase cathodes in glucose/oxygen fuel cells: FAD-dependent glucose dehydrogenase as a replacement.	Oxygen	101-107	hydroxyacid oxidase 1	Homo sapiens	30-45
24121716-3	2013	Experiments focused on determining the effect of the side reaction of GOx between its natural electron acceptor O2 (consumed) and hydrogen peroxide (produced) in the electrolyte.	Oxygen	112-114	hydroxyacid oxidase 1	Homo sapiens	70-73
24121716-4	2013	Firstly, oxygen consumption was investigated by both GOx and FAD-GDH in the presence of substrate.	Oxygen	9-15	hydroxyacid oxidase 1	Homo sapiens	53-56
24121716-6	2013	O2 consumption was observed with immobilized GOx only, whilst O2 concentration remained stable for the FAD-GDH.	Oxygen	0-2	hydroxyacid oxidase 1	Homo sapiens	45-48
24121716-10	2013	24 h stability experiments suggest that the use of O2-insensitive FAD-GDH as to obviate in situ peroxide production by GOx is effective.	Oxygen	51-53	hydroxyacid oxidase 1	Homo sapiens	119-122
24166980-1	2013	H2 , O2 to H2 O2 : The direct synthesis of hydrogen peroxide from hydrogen and oxygen in water has been made possible by using an iridium(III) complex, [Ir(III) (Cp*)(4-(1H-pyrazol-1-yl-kappaN(2) )benzoic acid-kappaC(3) )(H2 O)]2 SO4 , and flavin mononucleotide.	Oxygen	79-85	relaxin 2	Homo sapiens	0-16
21642830-1	2013	Methemoglobinemia occurs when hemoglobin is oxidized to form methemoglobin (MetHb) rendering it incapable of oxygen transport and leading to tissue hypoxia.	Oxygen	109-115	hemoglobin subunit gamma 2	Homo sapiens	61-74
21642830-1	2013	Methemoglobinemia occurs when hemoglobin is oxidized to form methemoglobin (MetHb) rendering it incapable of oxygen transport and leading to tissue hypoxia.	Oxygen	109-115	hemoglobin subunit gamma 2	Homo sapiens	76-81
24096875-5	2013	In the infarct heart, p53 was heavily acetylated at Lys(118) residue, which was exclusively reversed in the oxygenated heart, apparently regulated by oxygen-dependent expression of TIP60.	Oxygen	108-114	lysine acetyltransferase 5	Homo sapiens	181-186
23989195-10	2013	Statement 7 "The milder the RDS, the sooner the infant will find himself on 100% oxygen and maximal ventilatory support", scored the highest as being the most rubbish statement (94%).	Oxygen	81-87	peripherin 2	Homo sapiens	28-31
23999071-8	2013	Reoxygenation with 100% oxygen after hypoxia uniquely upregulated Gadd45g, Dusp1, Peg3, and Tgm2.	Oxygen	2-8	dual specificity phosphatase 1	Mus musculus	75-80
24032474-6	2013	Introduction of apo-GOx, instead of GOx, can avoid the consumption of O2 and production of H2O2 during the interaction with glucose, which may exert effects on normal physiological events in living cells and even lead to cellular damage.	Oxygen	70-72	hydroxyacid oxidase 1	Homo sapiens	20-23
24157153-0	2013	Hyperbaric oxygen intervention on expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in spinal cord injury models in rats.	Oxygen	11-17	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	48-79
24040138-10	2013	In conclusions, ATM (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest and allowed time to facilitate sperm-derived DNA-damage repair in mouse zygotes fertilized with oxygen-stressed sperm, and the DNA-damage repair might be effective.	Oxygen	195-201	checkpoint kinase 1	Mus musculus	32-36
24040163-12	2013	1% O2 induced F-actin reorganization, increase of Hif-1alpha, vimentin and alpha-SMA in HSC-T6 cells.	Oxygen	3-5	vimentin	Mus musculus	62-70
23815140-7	2013	Phosphorylation of IGF-I receptor by IGF-I was attenuated in low oxygen conditions.	Oxygen	65-71	insulin like growth factor 1 receptor	Homo sapiens	19-33
23940325-8	2013	A different negative feedback loop, mediated by phosphodiesterase-2 (PDE-2) and stimulated by cGMP-dependent kinase (PKG), unexpectedly promotes cGMP accumulation following a rise in O2, apparently by keeping in check gating of cGMP channels and limiting activation of Ca(2+)-dependent negative feedback loops.	Oxygen	183-185	putative 3',5'-cyclic phosphodiesterase pde-2	Caenorhabditis elegans	69-74
23680843-1	2013	In mammals, hypoxia-inducible factor-1 alpha (HIF-1alpha) is known to play important roles not only in oxygen homeostasis but also in innate immune responses.	Oxygen	103-109	hypoxia-inducible factor 1-alpha-like	Crassostrea gigas	12-44
23680843-1	2013	In mammals, hypoxia-inducible factor-1 alpha (HIF-1alpha) is known to play important roles not only in oxygen homeostasis but also in innate immune responses.	Oxygen	103-109	hypoxia-inducible factor 1-alpha-like	Crassostrea gigas	46-56
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	ankyrin repeat and sterile alpha motif domain containing 6	Danio rerio	38-43
23793029-6	2013	The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module.	Oxygen	4-10	ankyrin repeat and sterile alpha motif domain containing 6	Danio rerio	87-92
23587847-3	2013	Specifically, in transgenic neurons, elevated neuroglobin curtailed nitric oxide-induced alterations in mitochondrial oxygen consumption rates, including baseline oxygen consumption, consumption coupled with ATP synthesis, proton leak and spare respiratory capacity.	Oxygen	118-124	neuroglobin	Homo sapiens	46-57
23587847-3	2013	Specifically, in transgenic neurons, elevated neuroglobin curtailed nitric oxide-induced alterations in mitochondrial oxygen consumption rates, including baseline oxygen consumption, consumption coupled with ATP synthesis, proton leak and spare respiratory capacity.	Oxygen	163-169	neuroglobin	Homo sapiens	46-57
23460588-2	2013	Here, we describe a novel fetal methemoglobin variant discovered in a newborn found to have oxygen saturations significantly below normal upon pulse oximetry screening for congenital heart disease.	Oxygen	92-98	hemoglobin subunit gamma 2	Homo sapiens	32-45
23728383-11	2013	We confirm previous results obtained in rats and cell cultures that support the fundamental role of SNAT2 in fetal growth and well-being, as well as a possible role of oxygen levels in regulating SNAT2 expression, indicating the relevance of hypoxia in IUGR.	Oxygen	168-174	solute carrier family 38, member 2	Rattus norvegicus	196-201
23647309-0	2013	Arabidopsis plants lacking PsbQ and PsbR subunits of the oxygen-evolving complex show altered PSII super-complex organization and short-term adaptive mechanisms.	Oxygen	57-63	photosystem II subunit R	Arabidopsis thaliana	36-40
23716627-0	2013	Peroxisome proliferator-activated receptor-beta/delta regulates angiogenic cell behaviors and oxygen-induced retinopathy.	Oxygen	94-100	peroxisome proliferator activated receptor delta	Homo sapiens	0-53
23739964-5	2013	Here we show that ablating the oxygen (O2)-sensing URX neurons in npr-1(lf) mutants restores CO2 avoidance, suggesting that NPR-1 enables CO2 avoidance by inhibiting URX neurons.	Oxygen	31-37	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	66-71
23739964-5	2013	Here we show that ablating the oxygen (O2)-sensing URX neurons in npr-1(lf) mutants restores CO2 avoidance, suggesting that NPR-1 enables CO2 avoidance by inhibiting URX neurons.	Oxygen	31-37	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	124-129
23739964-5	2013	Here we show that ablating the oxygen (O2)-sensing URX neurons in npr-1(lf) mutants restores CO2 avoidance, suggesting that NPR-1 enables CO2 avoidance by inhibiting URX neurons.	Oxygen	39-41	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	66-71
23739964-5	2013	Here we show that ablating the oxygen (O2)-sensing URX neurons in npr-1(lf) mutants restores CO2 avoidance, suggesting that NPR-1 enables CO2 avoidance by inhibiting URX neurons.	Oxygen	39-41	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	124-129
23739964-7	2013	We find that, in npr-1(lf) mutants, O2-induced activation of URX inhibits CO2 avoidance.	Oxygen	36-38	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	17-22
23739964-8	2013	Moreover, both HW and npr-1(lf) animals avoid CO2 under low O2 conditions, when URX is inactive.	Oxygen	47-49	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	22-27
23809356-12	2013	A statistically non-significant trend for a prolonged O2 administration in period 2 (p = 0.0850) was also observed.	Oxygen	54-56	period circadian regulator 2	Homo sapiens	75-83
23703906-4	2013	In addition, loss of Miner1 caused a depletion of ER Ca(2+) stores, a dramatic increase in mitochondrial Ca(2+) load, increased reactive oxygen and nitrogen species, an increase in the GSSG/GSH and NAD(+)/NADH ratios, and an increase in the ADP/ATP ratio consistent with enhanced ATP utilization.	Oxygen	137-143	CDGSH iron sulfur domain 2	Mus musculus	21-27
23703906-5	2013	Furthermore, mitochondria in fibroblasts lacking Miner1 displayed ultrastructural alterations, such as increased cristae density and punctate morphology, and an increase in O2 consumption.	Oxygen	173-175	CDGSH iron sulfur domain 2	Mus musculus	49-55
23671091-2	2013	The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.	Oxygen	106-112	stearoyl-CoA desaturase	Homo sapiens	130-153
23713218-5	2013	RESULTS: Peak oxygen uptake during exercise using RAD and C2 averaged 3.11 +/- 0.49 and 3.18 +/- 0.50 L x min(-1), respectively.	Oxygen	14-20	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	50-53
23465832-7	2013	HIF-1alpha is the primarily oxygen-dependent regulated subunit of the heterodimeric transcription factor HIF-1, which controls angiogenesis among other physiological pathways.	Oxygen	28-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
23465832-8	2013	The truncated form of HIF-1alpha lacks the oxygen-dependent degradation domain (ODD) and therefore escapes degradation under normoxic conditions.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	22-32
23480575-3	2013	Quantum mechanical calculations using density function theory (DFT) indicate a modest decrease in bond dissociation enthalpy, BDE, for (weakest) hydrogen-oxygen phenolic bond in daidzein from 368.4 kJ   mol(- 1) to 367.7 kJ   mol(- 1) compared to a significant increase in quercetin from 329.5 kJ   mol(- 1) to 356.6 kJ   mol(- 1) upon derivatization.	Oxygen	154-160	homeobox D13	Homo sapiens	126-129
23459758-3	2013	Type I (also called glomus) cells, the site of O2 sensing in the carotid body, express haem oxygenase-2 and cystathionine-gamma-lyase, the enzymes which catalyse the generation of CO and H2S, respectively.	Oxygen	47-49	cystathionine gamma-lyase	Homo sapiens	92-133
23478801-2	2013	Here, for the first time to our knowledge, we reported that neuroglobin (Ngb), an intracellular hexa-coordinated globin serving as an oxygen/reactive oxygen species (ROS) sensor, functions as a tumor suppressor in hepatocelluar carcinoma (HCC).	Oxygen	134-141	neuroglobin	Homo sapiens	60-71
23478801-2	2013	Here, for the first time to our knowledge, we reported that neuroglobin (Ngb), an intracellular hexa-coordinated globin serving as an oxygen/reactive oxygen species (ROS) sensor, functions as a tumor suppressor in hepatocelluar carcinoma (HCC).	Oxygen	134-141	neuroglobin	Homo sapiens	73-76
23445365-6	2013	The binding of DMQn (n = 0 or 2) to GB1-hCLK-1 mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates O2 activation for subsequent DMQ hydroxylation.	Oxygen	145-147	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	36-39
23232944-5	2013	Short-term oxygen and glucose deprivation (OGD) resulted in upregulation of hypoxic markers and with a delay of 24 to 48 hours in selective nerve cell death in CA1.	Oxygen	11-17	carbonic anhydrase 1	Homo sapiens	160-163
23258710-5	2013	Moreover the surface capping on the QDs diminishes the photocatalytic activity of bare SnO(2) QDs due to absence of surface oxygen and adsorbed hydroxyl group on the surface of the capped QDs.	Oxygen	124-130	strawberry notch homolog 2	Homo sapiens	87-90
23131528-13	2013	CONCLUSIONS: The findings in this study suggest that LBP subjects present an impairment in their capacity to deliver oxygen at the level of the erector spinae muscle, which can be partly restored by an exercise therapy program.	Oxygen	117-123	lipopolysaccharide binding protein	Homo sapiens	53-56
23201478-7	2013	Analysis of oxygen uptake by isolated mitochondria showed that complex I and external NADH dehydrogenase activities were inhibited in GSNOR(OE) cells grown under nutritional stress.	Oxygen	12-18	alternative NAD(P)H dehydrogenase 1	Arabidopsis thaliana	86-104
23345396-0	2013	p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation.	Oxygen	30-36	sequestosome 1	Homo sapiens	0-3
23345396-0	2013	p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation.	Oxygen	30-36	sequestosome 1	Homo sapiens	4-10
23345396-0	2013	p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation.	Oxygen	30-36	egl-9 family hypoxia inducible factor 3	Homo sapiens	60-64
23643085-0	2013	[Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells].	Oxygen	35-37	aldo-keto reductase family 1 member A1	Homo sapiens	11-17
23643085-7	2013	Cells with knock-down of AKR1A1 were more sensitive to H2;O2; and 4-hydroxynonenal-induced cytotoxicity.	Oxygen	58-60	aldo-keto reductase family 1 member A1	Homo sapiens	25-31
23643085-8	2013	Furthermore, cellular ROS level in the cells with knock-down of AKR1A1 was much higher than that in the control cells in the presence of H2;O2;.	Oxygen	140-142	aldo-keto reductase family 1 member A1	Homo sapiens	64-70
23314690-6	2013	Hypermethylation with low oxygen tension was independently confirmed by bisulfite-pyrosequencing in a subset of functionally relevant genes including CD59, CFB, GRAM3 and ZNF217.	Oxygen	26-32	zinc finger protein 217	Homo sapiens	171-177
23247335-4	2013	The proposed mechanism suggests that O(2) is reduced by two electrons, each provided by one of two nonequivalent copper sites in PHM (Cu(H) and Cu(M)).	Oxygen	37-41	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	129-132
23247335-5	2013	The characteristics of the reduced oxygen species in the PHM reaction and the identity of the reactive intermediate remain uncertain.	Oxygen	35-41	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	57-60
23230825-4	2013	Treatment with HOT consisted of daily sessions of breathing 100% O(2) for a total of 75 min in the hyperbaric chamber with a minimum of eight sessions.	Oxygen	65-69	alcohol dehydrogenase iron containing 1	Homo sapiens	15-18
23092293-3	2013	In the present study we report kinetic studies on the reaction of KDM4E with O2.	Oxygen	77-79	lysine demethylase 4E	Homo sapiens	66-71
23092293-4	2013	Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations.	Oxygen	63-65	lysine demethylase 4E	Homo sapiens	32-37
23092293-4	2013	Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations.	Oxygen	107-109	lysine demethylase 4E	Homo sapiens	32-37
23092293-5	2013	Pre-steady state assays implied that KDM4E reacts slowly with O2 and that there are variations in the reaction kinetics which are dependent on the methylation status of the substrate.	Oxygen	62-64	lysine demethylase 4E	Homo sapiens	37-42
22879036-1	2013	Kidney uncoupling protein 2 (UCP-2) increases in streptozotocin-induced diabetes, resulting in mitochondria uncoupling, i.e., increased oxygen consumption unrelated to active transport.	Oxygen	136-142	uncoupling protein 2	Rattus norvegicus	29-34
23141926-9	2013	In support of this, PGC-1alpha(-/-) mice subjected to oxygen-induced retinopathy had decreased expression of VEGFA and were protected against pathological neovascularization.	Oxygen	54-60	vascular endothelial growth factor A	Mus musculus	109-114
23291753-5	2013	The oxygen-responsive regulator FnrL and a predicted iron-sensing regulator were perhaps also involved in the transcriptome response to reactive nitrogen species.	Oxygen	4-10	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	32-36
23924731-3	2013	The plasma diacron-reactive oxygen metabolite (dROM) level at 16 weeks of age was significantly higher in offspring of the protein-restricted dams, whereas the anti-oxidative enzyme activity was similar in both groups.	Oxygen	28-34	Drosomycin	Drosophila melanogaster	47-51
23595374-4	2013	The present study was conducted to investigate the feasibility of small interference RNA (siRNA) targeting VEGF gene in attenuating oxygen induced retinopathy (OIR) by regulating VEGF to PEDF ratio (VEGF/PEDF).	Oxygen	132-138	vascular endothelial growth factor A	Mus musculus	107-111
23662713-4	2013	Processes of metHb reduction and nitrosylation had the lag phase that was dependent on the presence of oxygen (O2) in the reaction mixture.	Oxygen	103-109	hemoglobin subunit gamma 2	Homo sapiens	13-18
23662713-4	2013	Processes of metHb reduction and nitrosylation had the lag phase that was dependent on the presence of oxygen (O2) in the reaction mixture.	Oxygen	111-113	hemoglobin subunit gamma 2	Homo sapiens	13-18
23011469-0	2013	Developmental programming of eNOS uncoupling and enhanced vascular oxidative stress in adult rats after transient neonatal oxygen exposure.	Oxygen	123-129	nitric oxide synthase 3	Rattus norvegicus	29-33
23011469-9	2013	Taken together, the current data indicate a role for eNOS uncoupling in enhanced vascular superoxide, impaired endothelium-mediated vasodilatation, and decreased NO production in adult animals with programmed elevated blood pressure after a brief neonatal oxygen exposure.	Oxygen	256-262	nitric oxide synthase 3	Rattus norvegicus	53-57
23342124-5	2013	Our results demonstrate that 3% O2 treatment can enhance rat MSC proliferation by upregulation of phosphorylated p38 MAPK and subsequent nuclear translocation of hypoxia inducible factor (HIF)-1alpha.	Oxygen	32-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	162-199
23342124-6	2013	During neural differentiation, 3% O2 treatment increases the expression of HIF-1alpha, phosphorylated ERK and p38 MAPK.	Oxygen	34-36	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	75-85
23144459-3	2012	Low steady-state levels of H(2)S appear to be controlled primarily by efficient oxygen-dependent catabolism via sulfide quinone oxidoreductase, persulfide dioxygenase (ETHE1), rhodanese, and sulfite oxidase.	Oxygen	80-86	sulfite oxidase	Homo sapiens	191-206
26291100-3	2012	Starting from 300 K and 500 mTorr of oxygen, the progressive formation of surface oxides is observed with increasing temperature: SnO, PtO units first, and SnO2, PtO2 units afterward.	Oxygen	37-43	strawberry notch homolog 2	Homo sapiens	130-133
23183047-7	2012	These data reveal a fundamental mechanism linking nutrient and oxygen sensing to transcriptional control of CD8+ T cell differentiation.	Oxygen	63-69	CD8a molecule	Homo sapiens	108-111
23070703-4	2012	By using electrophysiological and biochemical approaches, diverse mechanisms that dynamically regulate Panx1 channel function have been identified in various settings; these include, among others, activation by caspase-mediated channel cleavage in apoptotic immune cells, by G protein-coupled receptors in vascular smooth muscle, by low oxygen tension in erythrocytes and neurons, by high extracellular K(+) in various cell types and by stretch/strain in airway epithelia.	Oxygen	337-343	pannexin 1	Homo sapiens	103-108
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	solute carrier family 2 member 1	Homo sapiens	224-229
22943412-3	2012	A decrease in iO2 (intracellular O2) to 0-10 muM, induced by Baf, is sufficient for stabilization of HIFs (hypoxia inducible factors) HIF-1alpha and HIF-2alpha, coupled with an increased expression of target genes including GLUT1 (glucose transporter 1), HIF PHD2 (prolyl hydroxylase domain 2) and CAIX (carbonic anhydrase IX).	Oxygen	15-17	solute carrier family 2 member 1	Homo sapiens	231-252
23275324-1	2012	AIM: To evaluate the effect of hyperbaric oxygen therapy (HBOT) on superoxide dismutase 2 (SOD2) expression pattern after the cortical stab injury (CSI).	Oxygen	42-48	superoxide dismutase 2	Rattus norvegicus	67-89
23275324-1	2012	AIM: To evaluate the effect of hyperbaric oxygen therapy (HBOT) on superoxide dismutase 2 (SOD2) expression pattern after the cortical stab injury (CSI).	Oxygen	42-48	superoxide dismutase 2	Rattus norvegicus	91-95
23065119-3	2012	In the present work we demonstrate that heterologously expressed AAO1 and AAO3, two prominent members of the AO family from Arabidopsis thaliana, do not only generate hydrogen peroxide but also superoxide anions by transferring aldehyde-derived electrons to molecular oxygen.	Oxygen	268-274	abscisic aldehyde oxidase 3	Arabidopsis thaliana	74-78
23324150-8	2012	CONCLUSION: As an initial factor, low oxygen made HIF-1alpha, ET-1 and iNOS expression raised in the pathogenesis of HPH of the neonatal rats and causedn a imbalance of ET-1 and NO.	Oxygen	38-44	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	50-60
23110334-7	2012	On treating 2 with O2 as the oxidant in acetonitrile, besides formation of 4, additional evidence for oxygenation of L to L(ox), where one of the original phenyl units corresponds to a phenolate function, was found: The dinuclear complex [L(ox)Cu(OH)(OTf)CuL](OTf) (5) was isolated as the final product of O2 activation and conversion, which resembles the one of tyrosinase.	Oxygen	19-21	tyrosinase	Homo sapiens	363-373
23257033-1	2012	OBJECTIVE: To observe and evaluate the performances of intermittent positive pressure ventilation, beta-2 adrenergic receptor agonist, and pressure lavage in promoting residual fluid absorption and improving blood oxygen saturation during massive whole lung lavage (WLL).	Oxygen	214-220	adrenoceptor beta 2	Homo sapiens	99-125
22846720-8	2012	Moreover, we demonstrated in a mouse model that both the pharmacological inhibition and the DeltaF508 mutation of CFTR lead to an impairment of the adaptive erythroid response to oxygen deprivation.	Oxygen	179-185	cystic fibrosis transmembrane conductance regulator	Mus musculus	114-118
22200380-0	2012	A comparison of glucose oxidase and aldose dehydrogenase as mediated anodes in printed glucose/oxygen enzymatic fuel cells using ABTS/laccase cathodes.	Oxygen	95-101	hydroxyacid oxidase 1	Homo sapiens	16-31
22902248-6	2012	RESULTS: SF-6 (1, 5 and 10 mug/mL) significantly inhibited alpha-synuclein- or 6-OHDA-, H(2)O(2)-induced cytotoxicity and decreased the reactive oxygen species production in SH-SY5Y cells.	Oxygen	145-151	splicing factor 1	Homo sapiens	9-26
22787195-0	2012	Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation.	Oxygen	123-129	CD8a molecule	Homo sapiens	7-10
22787195-6	2012	Moreover, memory T cells are sufficient to ameliorate the increased morbidity and mortality and alleviate the excessive lung damage observed in mice exposed to high oxygen levels as neonates, and we attribute this sufficiency principally to virus-specific memory CD8(+) T cells.	Oxygen	165-171	CD8a molecule	Homo sapiens	263-266
21605070-6	2012	Independent of oxygen status, siRNA-VEGF reduced VEGF levels resulting in decreased AKT and increased JNK phosphorylation in Hepa129 cells.	Oxygen	15-21	vascular endothelial growth factor A	Mus musculus	36-40
22634334-8	2012	Curcumin-modified TrxR1 dose-dependently and quantitatively transfers electrons from NADPH to oxygen with the production of ROS.	Oxygen	94-100	thioredoxin reductase 1	Homo sapiens	18-23
22801492-9	2012	SHARP1 therefore determines the intrinsic instability of HIF proteins to act in parallel to, and cooperate with, oxygen levels.	Oxygen	113-119	basic helix-loop-helix family member e41	Homo sapiens	0-6
22716229-5	2012	The high value of DeltaH(H2) stems from the preferential electrostatic interaction of H(2) with the pendent oxygen atoms of Himdc and aromatic bipy linkers as determined from first-principles density functional theory (DFT) based calculations.	Oxygen	108-114	relaxin 2	Homo sapiens	18-27
22562603-3	2012	The primordial ROS (superoxide) is generated by the reduction of molecular oxygen by NADPH via redox centers located on Nox2.	Oxygen	75-81	cytochrome b-245 beta chain	Homo sapiens	120-124
22787088-0	2012	Selective activation of oxygen-deprived tumor-infiltrating lymphocytes through local intratumoral delivery of CD137 monoclonal antibodies.	Oxygen	24-30	TNF receptor superfamily member 9	Homo sapiens	110-115
22266991-12	2012	Significant MUE x PigG interactions were observed for hematocrit and hemoglobin, in which the greatest concentrations were observed in MS piglets gestated in MS and WC gilts, and the lowest concentrations were observed in WC piglets gestated in WC gilts, demonstrating increased oxygen-carrying capability.	Oxygen	279-285	HGB	Sus scrofa	69-79
22596262-11	2012	DNase 1 inhalation prevents their alveolar accumulation and improves arterial oxygen saturation even when administered 90 minutes after TRALI onset.	Oxygen	78-84	deoxyribonuclease 1	Homo sapiens	0-7
22642831-9	2012	The k(cat)/K(O2)-pH profiles for wild-type Fms1 and the H67A enzyme both show a pK(a) of about ~6.9; this suggests His67 is not responsible for this pH behavior.	Oxygen	13-15	polyamine oxidase	Saccharomyces cerevisiae S288C	43-47
22243719-7	2012	There was a significant O(2) -dependent increase in the secretion of IL-10 (P &lt; 0.01) and decrease in TNFalpha/IL-10 ratio (P &lt; 0.005) in the culture medium in both groups.	Oxygen	24-28	interleukin 10	Homo sapiens	69-74
22243719-7	2012	There was a significant O(2) -dependent increase in the secretion of IL-10 (P &lt; 0.01) and decrease in TNFalpha/IL-10 ratio (P &lt; 0.005) in the culture medium in both groups.	Oxygen	24-28	interleukin 10	Homo sapiens	114-119
22658994-6	2012	PUFA supplementation of macrophages in the presence of R. equi or P. aeruginosa reduced the pathogen-stimulated synthesis of reactive nitrogen and oxygen intermediates.	Oxygen	147-153	pumilio RNA binding family member 3	Homo sapiens	0-4
22530945-9	2012	A relevant approach to the NOS mechanism would use H4B to provide the (second) electron involved in oxygen activation; water radiolysis would thus provide the first electron (heme reduction).	Oxygen	100-106	H4 clustered histone 4	Homo sapiens	51-54
22233353-3	2012	Purified His(6) -tagged HopN1 was used to identify tomato PsbQ, a member of the oxygen evolving complex of photosystem II (PSII), as an interacting protein.	Oxygen	80-86	type III secretion system effector cysteine protease HopN1	Pseudomonas syringae pv. tomato str. DC3000	24-29
22402262-4	2012	The ZTL/FKF1/LKP2 protein family possesses a unique combination of domains: a blue-light-absorbing LOV (Light, Oxygen, or Voltage) domain along with domains involved in protein degradation.	Oxygen	111-117	LOV KELCH protein 2	Arabidopsis thaliana	13-17
22415514-6	2012	We propose that H(2)O(2) production under O(2) deprivation is a trait present in a very early phase of anoxia, and that ROS are needed for the regulation of a set of genes belonging to the heat shock protein and ROS-mediated groups.	Oxygen	20-24	heat shock protein	Arabidopsis thaliana	189-207
22562611-1	2012	The NEET family is a newly discovered group of proteins involved in a diverse array of biological processes, including autophagy, apoptosis, aging, diabetes, and reactive oxygen homeostasis.	Oxygen	171-177	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	4-8
22562611-5	2012	Phenotypic characterization of At-NEET revealed a key role for this protein in plant development, senescence, reactive oxygen homeostasis, and Fe metabolism.	Oxygen	119-125	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	34-38
22575745-6	2012	Upon ex vivo challenge with pneumococcus, EP2(-/-)cells expressed greater amounts of TNF-alpha and MIP-2 than did EP2(+/+) AMs, and had improved phagocytosis, intracellular killing, and reactive oxygen intermediate generation.	Oxygen	195-201	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	42-45
22360297-3	2012	This study evaluates the association between S100beta, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo(2)).	Oxygen	210-216	glial fibrillary acidic protein	Homo sapiens	90-121
22360297-3	2012	This study evaluates the association between S100beta, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo(2)).	Oxygen	210-216	glial fibrillary acidic protein	Homo sapiens	123-127
22399131-4	2012	We hypothesize that this highly conserved EIEYE sequence in the TbpA plug, rich in hard oxygen donor groups, binds with Fe(3+) through the transport process across the outer membrane through the beta-barrel.	Oxygen	88-94	transthyretin	Homo sapiens	64-68
22405203-0	2012	CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.	Oxygen	26-28	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	49-54
21943108-11	2012	In a rat model of oxygen-induced retinopathy, A11 strongly inhibited retinal angiogenesis.	Oxygen	18-24	selectin L	Rattus norvegicus	46-49
22101835-13	2012	A significant decrease in PO(2) was observed along most retinal microvessels, indicative of substantial oxygen extraction by the retinal tissue.	Oxygen	104-110	myeloperoxidase	Mus musculus	26-28
22323203-1	2012	A key cellular adaptation to diving in Weddell seals is enhanced myoglobin concentrations in their skeletal muscles, which serve to store oxygen to sustain a lipid-based aerobic metabolism.	Oxygen	138-144	myoglobin	Leptonychotes weddellii	65-74
22437533-7	2012	Our findings suggest that conglutinin bound to sugar residues on microbial surfaces can induce oxygen burst in phagocytes, and thereby mediates the elimination of pathogens and prevents the spread of infection.	Oxygen	95-101	conglutinin	Bos taurus	26-37
24323752-4	2012	Additionally, we have evaluated the effects of high-flow oxygen on the natural history of penumbral evolution, demonstrating that high-flow oxygen "freezes" the evolution of the mismatch and allows for later beneficial use of intravenous tissue plasminogen activator (tPA).	Oxygen	140-146	chromosome 20 open reading frame 181	Homo sapiens	238-266
24323752-4	2012	Additionally, we have evaluated the effects of high-flow oxygen on the natural history of penumbral evolution, demonstrating that high-flow oxygen "freezes" the evolution of the mismatch and allows for later beneficial use of intravenous tissue plasminogen activator (tPA).	Oxygen	140-146	chromosome 20 open reading frame 181	Homo sapiens	268-271
22233504-8	2012	The expression of AQP5 in the group of high concentration of oxygen progressively decreased and such difference with the control group was significant (p &lt; 0.05).	Oxygen	61-67	aquaporin 5	Rattus norvegicus	18-22
22233504-9	2012	The four experimental methods all showed the expression of HoxB5 in the group with high concentration of oxygen gradually decreased since day 7 (p &lt; 0.05).	Oxygen	105-111	homeo box B5	Rattus norvegicus	59-64
22178740-9	2012	By contrast, the combination arsenite+CAPE showed high levels of O2- production at 6h and 24 h post exposure but resulted in antagonism over cell death and growth inhibition effects in U937 and Raji cells.	Oxygen	65-67	structural maintenance of chromosomes 2	Homo sapiens	38-42
22472890-5	2012	An increased hypoxia inducible factor-1alpha (HIF-1alpha) translocation and vascular endothelial growth factor (VEGF) expression has been found upon 95% oxygen exposure to induce morphological modifications.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	13-44
22472890-5	2012	An increased hypoxia inducible factor-1alpha (HIF-1alpha) translocation and vascular endothelial growth factor (VEGF) expression has been found upon 95% oxygen exposure to induce morphological modifications.	Oxygen	153-159	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	46-56
22472890-6	2012	Upstream pPKC-alpha expression increase in newborn rats exposed to 95% oxygen can suggest PKC involvement in HIF-1alpha activation.	Oxygen	71-77	protein kinase C, gamma	Rattus norvegicus	10-13
22472890-6	2012	Upstream pPKC-alpha expression increase in newborn rats exposed to 95% oxygen can suggest PKC involvement in HIF-1alpha activation.	Oxygen	71-77	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	109-119
22159013-9	2012	However, using the oxygen-induced retinopathy model, the authors demonstrated that opticin knockout mice produce significantly more preretinal neovascularization than wild-type mice, and the intravitreal delivery of excess opticin inhibited the formation of neovessels in wild-type mice.	Oxygen	19-25	opticin	Mus musculus	83-90
22159013-9	2012	However, using the oxygen-induced retinopathy model, the authors demonstrated that opticin knockout mice produce significantly more preretinal neovascularization than wild-type mice, and the intravitreal delivery of excess opticin inhibited the formation of neovessels in wild-type mice.	Oxygen	19-25	opticin	Mus musculus	223-230
22127526-4	2012	The hole trap states are localized at oxygen anions in both the bulk and surface.	Oxygen	38-44	TRAP	Homo sapiens	9-13
22127526-6	2012	The electron trap level at the surface oxygen vacancy is consistent with observations by photoelectron spectroscopy.	Oxygen	39-45	TRAP	Homo sapiens	13-17
23080171-1	2012	Hypoxia inducible factor 1(HIF-1alpha) is the regulator of oxygen homeostasis in tissue correlated with neuroglobin (NGB) a member of the family of globins in vertebrates.	Oxygen	59-65	neuroglobin	Homo sapiens	104-115
23080171-1	2012	Hypoxia inducible factor 1(HIF-1alpha) is the regulator of oxygen homeostasis in tissue correlated with neuroglobin (NGB) a member of the family of globins in vertebrates.	Oxygen	59-65	neuroglobin	Homo sapiens	117-120
23080171-5	2012	The increase of NGB and HIF-1alpha expression suggests a possible role of the two oxygen sensors in the aging processes.	Oxygen	82-88	neuroglobin	Homo sapiens	16-19
23080174-7	2012	Both normoxia (20%O(2)/5%CO(2)) and hypoxia (0%O(2)/5%CO(2)) induced a similar increase in the FRET emission ratio (14.5 +- 0.8 and 14.7 +- 0.8, respectively).PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole SCG with no modulation by hypoxia.	Oxygen	26-30	phosphodiesterase 4D	Homo sapiens	176-181
22969859-9	2012	The oxygen enhancement ratio at 10% surviving fraction was calculated as 2.7 and 2.6 in the presence and the absence of YC-1, respectively.	Oxygen	4-10	RNA binding motif single stranded interacting protein 1	Homo sapiens	120-124
21912378-0	2012	Bone marrow-derived monocyte lineage cells recruited by MIP-1beta promote physiological revascularization in mouse model of oxygen-induced retinopathy.	Oxygen	124-130	chemokine (C-C motif) ligand 4	Mus musculus	56-65
21912378-3	2012	Our earlier study on the gene expression profile of hypoxic retinas in a mouse model of oxygen-induced retinopathy (OIR) showed that macrophage inflammatory protein-1beta (MIP-1beta) was the most upregulated protein.	Oxygen	88-94	chemokine (C-C motif) ligand 4	Mus musculus	133-170
21912378-3	2012	Our earlier study on the gene expression profile of hypoxic retinas in a mouse model of oxygen-induced retinopathy (OIR) showed that macrophage inflammatory protein-1beta (MIP-1beta) was the most upregulated protein.	Oxygen	88-94	chemokine (C-C motif) ligand 4	Mus musculus	172-181
22773903-3	2012	The aims of the present study were to evaluate the heparanase expression and its relationship with VEGF in the retina of oxygen-induced retinopathy (OIR) mice, and to investigate the effect of the heparanase inhibitor phosphomannopentaose sulfate (PI-88) in the OIR retinas.	Oxygen	121-127	vascular endothelial growth factor A	Mus musculus	99-103
22086331-0	2012	Transient MPK6 activation in response to oxygen deprivation and reoxygenation is mediated by mitochondria and aids seedling survival in Arabidopsis.	Oxygen	41-47	MAP kinase 6	Arabidopsis thaliana	10-14
22086331-2	2012	Here, we report the rapid and transient activation of MPK3, MPK4 and MPK6 upon oxygen deprivation as well as reoxygenation in seedlings of Arabidopsis thaliana.	Oxygen	79-85	mitogen-activated protein kinase 3	Arabidopsis thaliana	54-58
22086331-2	2012	Here, we report the rapid and transient activation of MPK3, MPK4 and MPK6 upon oxygen deprivation as well as reoxygenation in seedlings of Arabidopsis thaliana.	Oxygen	79-85	MAP kinase 6	Arabidopsis thaliana	69-73
22086331-4	2012	MPK6 was the predominant kinase regulated by oxygen availability in both aerial and root tissue, except in mpk6 mutants, which displayed compensatory activation of MPK3.	Oxygen	45-51	MAP kinase 6	Arabidopsis thaliana	0-4
22086331-8	2012	We found that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3, MPK4 and MPK6, but the induction of mRNAs associated with low oxygen acclimation responses were not markedly altered in MPK6 overexpression lines or mpk6 loss-of-function mutants.	Oxygen	45-51	mitogen-activated protein kinase 3	Arabidopsis thaliana	121-125
22086331-8	2012	We found that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3, MPK4 and MPK6, but the induction of mRNAs associated with low oxygen acclimation responses were not markedly altered in MPK6 overexpression lines or mpk6 loss-of-function mutants.	Oxygen	45-51	MAP kinase 6	Arabidopsis thaliana	136-140
23251335-6	2012	Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein.	Oxygen	57-63	Globin-like protein 26	Caenorhabditis elegans	6-12
21692070-10	2011	Oxygen and bone morphogenetic protein 9 levels were shown to modulate TGF-beta-induced VEGFR2 down-regulation.	Oxygen	0-6	kinase insert domain receptor	Homo sapiens	87-93
21951999-3	2011	The alpha-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent manner.	Oxygen	132-138	egl-9 family hypoxia inducible factor 3	Homo sapiens	120-124
21899660-7	2011	Since NO is significantly associated with cell metabolism, we measured the levels of pyruvate dehydrogenase kinase-1 (PDK-1), reactive oxygen species, and oxygen and observed that the expression of PDK-1 was significantly reduced.	Oxygen	135-141	pyruvate dehydrogenase kinase 1	Homo sapiens	198-203
22067127-0	2011	Expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy.	Oxygen	78-84	vascular endothelial growth factor A	Mus musculus	51-55
22243227-6	2011	Based on our previous studies using the neuronal PC12 cell model, in which tuftelin induction was mediated by Hif1a, we propose that tuftelin is a member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating MSC function.	Oxygen	157-163	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	110-115
22034287-0	2011	Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana.	Oxygen	0-6	hemoglobin 1	Arabidopsis thaliana	70-74
21793005-0	2011	Density functional study of neutral and anionic AlO(n)  and ScO(n)  with high oxygen content.	Oxygen	78-84	DELYQ11	Homo sapiens	60-63
21901864-5	2011	4-10% O(2) was associated with large increases in the total production of viable cells and the highest number of cells expressing Nestin, betaIII tubulin, and MAP2.	Oxygen	6-10	tubulin, beta 3 class III	Mus musculus	138-153
21901864-9	2011	A step increase from 0 to 2% O(2) mid-way through the protocol resulted in the highest percentage of cells expressing betaIII tubulin (86.5%).	Oxygen	29-33	tubulin, beta 3 class III	Mus musculus	118-133
21083501-1	2011	Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1-3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner.	Oxygen	86-92	egl-9 family hypoxia-inducible factor 2	Mus musculus	73-80
21083501-1	2011	Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1-3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner.	Oxygen	147-153	egl-9 family hypoxia-inducible factor 2	Mus musculus	73-80
21479966-7	2011	Soluble TWEAK levels were inversely correlated with NYHA class, pulmonary artery pressure, pulmonary vascular resistance, NT-proBNP, and troponin T levels and directly correlated with cardiac index, reduced 6-min walk test distances, and peak oxygen consumption.	Oxygen	243-249	TNF superfamily member 12	Homo sapiens	8-13
22220412-6	2011	Immunohistochemical and Western blot analysis of frozen masseter muscle samples showed a transient upregulation of myoD and myogenin transcriptional factors in the muscles of hyperbaric oxygen treated rats and of rats that have not been treated after the injury.	Oxygen	186-192	myogenin	Rattus norvegicus	124-132
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	Oxygen	115-121	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	67-74
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	Oxygen	115-121	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	129-135
21753061-8	2011	Taken together, these results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of IRP in response to dietary iron deficiency and provide evidence that IRP may assist in coordinating the cellular response to alterations in iron and oxygen status associated with iron deficiency anemia.	Oxygen	273-279	endothelial PAS domain protein 1	Rattus norvegicus	62-72
21873995-0	2011	TRPA1 underlies a sensing mechanism for O2.	Oxygen	40-42	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
21873995-3	2011	Here our systematic evaluation of transient receptor potential (TRP) cation channels using reactive disulfides with different redox potentials reveals the capability of TRPA1 to sense O(2).	Oxygen	184-188	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	169-174
21873995-4	2011	O(2) sensing is based upon disparate processes: whereas prolyl hydroxylases (PHDs) exert O(2)-dependent inhibition on TRPA1 activity in normoxia, direct O(2) action overrides the inhibition via the prominent sensitivity of TRPA1 to cysteine-mediated oxidation in hyperoxia.	Oxygen	0-4	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	118-123
21873995-4	2011	O(2) sensing is based upon disparate processes: whereas prolyl hydroxylases (PHDs) exert O(2)-dependent inhibition on TRPA1 activity in normoxia, direct O(2) action overrides the inhibition via the prominent sensitivity of TRPA1 to cysteine-mediated oxidation in hyperoxia.	Oxygen	0-4	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	223-228
21873995-4	2011	O(2) sensing is based upon disparate processes: whereas prolyl hydroxylases (PHDs) exert O(2)-dependent inhibition on TRPA1 activity in normoxia, direct O(2) action overrides the inhibition via the prominent sensitivity of TRPA1 to cysteine-mediated oxidation in hyperoxia.	Oxygen	89-93	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	118-123
21873995-4	2011	O(2) sensing is based upon disparate processes: whereas prolyl hydroxylases (PHDs) exert O(2)-dependent inhibition on TRPA1 activity in normoxia, direct O(2) action overrides the inhibition via the prominent sensitivity of TRPA1 to cysteine-mediated oxidation in hyperoxia.	Oxygen	89-93	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	118-123
21873995-7	2011	The results suggest a new O(2)-sensing mechanism mediated by TRPA1.	Oxygen	26-30	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	61-66
21530688-7	2011	The O(2)-sensitive TASK activity was significantly greater in glomus cells from P16 to P18 when compared to cells from P0 to P1 day old rats.	Oxygen	4-8	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	80-83
21530688-7	2011	The O(2)-sensitive TASK activity was significantly greater in glomus cells from P16 to P18 when compared to cells from P0 to P1 day old rats.	Oxygen	4-8	cyclin-dependent kinase inhibitor 2C	Rattus norvegicus	87-90
21742463-2	2011	Since there is evidence for a role of G protein receptors as oxygen sensor(s) implicated in cell volume regulation, we hypothesized that erythrocyte TSHR, by TSH stimulation, could modify the erythrocyte volume and the oxygenation state of erythrocytes.	Oxygen	61-67	thyroid stimulating hormone receptor	Homo sapiens	149-153
21701263-4	2011	Here, we demonstrate that siRNA oligonucleotides targeting the mRNA surveillance proteins SMG1, Upf1, Upf2, or the PIKK protein ATM attenuated p53 (ser15) phosphorylation in cells damaged by high oxygen (hyperoxia), a model of persistent oxidative stress that damages nucleotides.	Oxygen	196-202	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	90-94
25214132-2	2011	Electrochemical measurements were carried out by following the consumed oxygen due to the enzymatic reaction of glucose oxidase (GOx) at -0.7V vs Ag/AgCl.	Oxygen	72-78	hydroxyacid oxidase 1	Homo sapiens	112-127
25214132-2	2011	Electrochemical measurements were carried out by following the consumed oxygen due to the enzymatic reaction of glucose oxidase (GOx) at -0.7V vs Ag/AgCl.	Oxygen	72-78	hydroxyacid oxidase 1	Homo sapiens	129-132
21535296-1	2011	OBJECTIVE:   This investigation tested the hypothesis that selective nNOS inhibition would lower the dynamic microvascular O2 delivery/utilization () balance (which sets the Po(2) mv) in rat skeletal muscle at rest and during contractions.	Oxygen	123-125	nitric oxide synthase 1	Rattus norvegicus	69-73
21894325-6	2011	Pre-administration of TAK-085 to the Abeta-infused rats significantly suppressed the number of reference and working memory errors and decreased the levels of lipid peroxide and reactive oxygen species in the cerebral cortex and hippocampus of Abeta-infused rats, suggesting that TAK-085 increases antioxidative defenses.	Oxygen	187-193	amyloid beta precursor protein	Rattus norvegicus	37-42
21483406-10	2011	Interestingly, ZNF217 was upregulated in GSCs and the GBM cell line U87 when exposed to the hypoxic environment of 1% oxygen.	Oxygen	118-124	zinc finger protein 217	Homo sapiens	15-21
21697371-5	2011	Similarly, exposure to low oxygen conditions in vitro induced stem-cell-like potential in immature cortical GFAP(+) cells.	Oxygen	27-33	glial fibrillary acidic protein	Homo sapiens	108-112
21618975-10	2011	In the photoluminescence (PL) spectrum, SnO(2):F nanocrystals exhibited a broad green emission arising from the singly ionized oxygen vacancies created due to higher dopant concentration.	Oxygen	127-133	strawberry notch homolog 2	Homo sapiens	40-43
21618975-12	2011	The disordered nature of the rutile lattice and the enormous oxygen vacancies created due to fluoride ion doping were evident from the broad bands observed at 455, 588, and 874 cm(-1) in the room-temperature Raman spectrum of SnO(2):F. As the consequence of the oxygen vacancies, F-doped SnO(2) was examined for the function as a photocatalyst in the degradation of aqueous RhB dye solution under UV irradiation.	Oxygen	61-67	strawberry notch homolog 2	Homo sapiens	226-229
21618975-12	2011	The disordered nature of the rutile lattice and the enormous oxygen vacancies created due to fluoride ion doping were evident from the broad bands observed at 455, 588, and 874 cm(-1) in the room-temperature Raman spectrum of SnO(2):F. As the consequence of the oxygen vacancies, F-doped SnO(2) was examined for the function as a photocatalyst in the degradation of aqueous RhB dye solution under UV irradiation.	Oxygen	61-67	strawberry notch homolog 2	Homo sapiens	288-291
21618975-12	2011	The disordered nature of the rutile lattice and the enormous oxygen vacancies created due to fluoride ion doping were evident from the broad bands observed at 455, 588, and 874 cm(-1) in the room-temperature Raman spectrum of SnO(2):F. As the consequence of the oxygen vacancies, F-doped SnO(2) was examined for the function as a photocatalyst in the degradation of aqueous RhB dye solution under UV irradiation.	Oxygen	262-268	strawberry notch homolog 2	Homo sapiens	226-229
21618975-16	2011	The increased photocatalytic efficiency was related to the very high concentration of oxygen vacancies in SnO(2) induced by F doping.	Oxygen	86-92	strawberry notch homolog 2	Homo sapiens	106-109
21357392-0	2011	Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog.	Oxygen	63-69	vascular endothelial growth factor A	Canis lupus familiaris	10-14
21357392-7	2011	Other oxygen-exposed animals received 5 mug of VEGF Trap or hFc on P22 after confirmation of retinopathy of prematurity (ROP)-like pathology and were evaluated at P45.	Oxygen	6-12	vascular endothelial growth factor A	Canis lupus familiaris	47-51
21357392-11	2011	In oxygen-treated animals, all eyes injected with VEGF Trap exhibited markedly less intravitreal NV than that of hFc-injected fellow eyes, irrespective of dose.	Oxygen	3-9	vascular endothelial growth factor A	Canis lupus familiaris	50-54
21483450-0	2011	The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.	Oxygen	4-10	egl-9 family hypoxia inducible factor 3	Homo sapiens	18-22
21512133-6	2011	We have previously identified HAF as an E3 ubiquitin ligase that binds and ubiquitinates HIF-1alpha by an oxygen and pVHL-independent mechanism, thus targeting HIF-1alpha for proteasomal degradation.	Oxygen	106-112	coagulation factor XII	Homo sapiens	30-33
21692205-2	2011	We then determined the netrin-1 and VEGF expression in the oxygen induced retinopathy (OIR) mice retinas.	Oxygen	59-65	vascular endothelial growth factor A	Mus musculus	36-40
21602909-3	2011	In this study, we monitored field potentials and contents of oxygen and NAD(P)H in correlation with oxidative metabolism during intense network activity in the CA1 hippocampal region of neonatal brain slices.	Oxygen	61-67	carbonic anhydrase 1	Homo sapiens	160-163
21217781-3	2011	Hif regulation by oxygen requires the protein von Hippel-Lindau (pVhl) and pVhl disruption results in constitutive Hif activation.	Oxygen	18-24	von Hippel-Lindau tumor suppressor	Mus musculus	65-69
21217781-3	2011	Hif regulation by oxygen requires the protein von Hippel-Lindau (pVhl) and pVhl disruption results in constitutive Hif activation.	Oxygen	18-24	von Hippel-Lindau tumor suppressor	Mus musculus	75-79
21729625-6	2011	The level of MAGL was related to some indices of severity of OSA, including the longest apnea time, lowest blood oxygen saturation and the micro-arousal index (r = 0.31, 0.24, 0.34, respectively, all P &lt; 0.05).	Oxygen	113-119	monoglyceride lipase	Homo sapiens	13-17
21320746-3	2011	Furthermore, the expression of HIF-1alpha induced by SCF is not dependent on the oxygen level, but rather on both the PI3K/Akt and Ras/MEK/ERK signaling pathways.	Oxygen	81-87	KIT ligand	Homo sapiens	53-56
20501520-1	2011	Delta-aminolevulinate dehydratase (delta-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen.	Oxygen	111-117	aminolevulinate dehydratase	Homo sapiens	0-33
20501520-1	2011	Delta-aminolevulinate dehydratase (delta-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen.	Oxygen	111-117	aminolevulinate dehydratase	Homo sapiens	35-46
21413860-0	2011	Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid.	Oxygen	9-15	T cell leukemia homeobox 2	Homo sapiens	113-116
21413860-10	2011	In monkey eyes, NCX 434 enhanced, whereas TA did not, oxygen saturation in various ONH areas (*P&lt;0.05 vs. basal), decreased it in veins, and did not affect it in the overlaying arteries.	Oxygen	54-60	T cell leukemia homeobox 2	Homo sapiens	16-19
21256194-1	2011	Congenital central hypoventilation syndrome (CCHS), a condition associated with mutations in the PHOX2B gene, is characterized by loss of breathing drive during sleep, insensitivity to CO2 and O2, and multiple somatomotor, autonomic, neuropsychological, and ophthalmologic deficits, including impaired intrinsic and extrinsic eye muscle control.	Oxygen	186-188	paired like homeobox 2B	Homo sapiens	97-103
21266576-7	2011	Taken together, our data suggest that the hypoxia-induced expression of GPER may be included among the mechanisms involved in the anti-apoptotic effects elicited by estrogens, particularly in a low oxygen microenvironment.	Oxygen	198-204	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
21325719-16	2011	For RDX it was observed that the oxygen lone-pair concentrations of electrons are located close to perpendicular to the N-O bond vectors, which is typical for explosive materials.	Oxygen	33-39	radixin	Homo sapiens	4-7
21055385-3	2011	After binding oxygen, the oxyferrous protein accepts a second electron which is provided by either cytochrome P450 reductase or cytochrome b(5).	Oxygen	14-20	mitochondrially encoded cytochrome b	Homo sapiens	128-140
21256215-10	2011	Both CD47 and TSP1 null mice are leaner than WTs, use less oxygen and produce less heat than WT mice.	Oxygen	59-65	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	5-9
21215271-5	2011	Furthermore, both GPx7 and GPx8 interact with Ero1alpha in vivo, and GPx7 significantly increases oxygen consumption by Ero1alpha in vitro.	Oxygen	98-104	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	120-129
21053058-3	2011	Increased expression of the hypoxia-inducible factor-1alpha-subunit (HIF-1alpha) is also associated with tumour progression and is also known to induce HGF-signaling via up-regulation of the HGF-receptor Met, namely under canonical stress conditions like lack of oxygen.	Oxygen	263-269	hepatocyte growth factor	Mus musculus	152-155
21047919-0	2011	Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia.	Oxygen	32-38	HtrA serine peptidase 3	Homo sapiens	10-15
21047919-10	2011	Oxygen tension regulated HtrA3; low oxygen enhanced, whereas the transition from low to high oxygen decreased, HtrA3 protein production in syncytiotrophoblast.	Oxygen	0-6	HtrA serine peptidase 3	Homo sapiens	25-30
21047919-10	2011	Oxygen tension regulated HtrA3; low oxygen enhanced, whereas the transition from low to high oxygen decreased, HtrA3 protein production in syncytiotrophoblast.	Oxygen	0-6	HtrA serine peptidase 3	Homo sapiens	111-116
21047919-13	2011	CONCLUSIONS: HtrA3 protein production is closely associated with changing in oxygen tension in the placenta.	Oxygen	77-83	HtrA serine peptidase 3	Homo sapiens	13-18
21047919-14	2011	The decline in HtrA3 at the end of first trimester may reflect the placental low to high oxygen switch.	Oxygen	89-95	HtrA serine peptidase 3	Homo sapiens	15-20
21074167-8	2011	H(2)-TPR results suggest that the reductions of surface and bulk oxygen of ceria were predominant at low and high calcination temperature, respectively.	Oxygen	65-71	translocated promoter region, nuclear basket protein	Homo sapiens	5-8
21163314-0	2011	Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA.	Oxygen	77-83	serpin family I member 2	Rattus norvegicus	26-37
21146209-0	2011	Oxygen concentration regulates expression and uptake of transthyretin, a thyroxine binding protein, in JEG-3 choriocarcinoma cells.	Oxygen	0-6	transthyretin	Homo sapiens	56-69
21146209-6	2011	This suggests that increased carrier mediated T(4) transport by placental TTR may be induced by the low oxygen environment of early pregnancy, a time when the fetus has its highest requirement for transport of maternal T(4).	Oxygen	104-110	transthyretin	Homo sapiens	74-77
21144829-5	2011	Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type.	Oxygen	0-6	Transmembrane GTPase fzo-1	Caenorhabditis elegans	109-114
21047504-12	2011	Together our data suggest bim expression may be responsible for the inherent sensitivity of the developing retinal vasculature to changes in oxygen levels, and promotes vessel obliteration in response to hyperoxia.	Oxygen	141-147	BCL2-like 11 (apoptosis facilitator)	Mus musculus	26-29
21209208-7	2011	However, lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons in vitro as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia in vivo.	Oxygen	72-78	Fas apoptotic inhibitory molecule 2	Mus musculus	17-22
21535678-0	2011	Effects of argon enriched low-oxygen atmospheres and of high-oxygen atmospheres on the kinetics of polyphenoloxidase (PPO).	Oxygen	61-67	polyphenol oxidase, chloroplastic	Malus domestica	99-116
21535678-0	2011	Effects of argon enriched low-oxygen atmospheres and of high-oxygen atmospheres on the kinetics of polyphenoloxidase (PPO).	Oxygen	61-67	polyphenol oxidase, chloroplastic	Malus domestica	118-121
21535678-4	2011	Km(app) values (mM) for apple PPO in 3%O(2)/97%Ar, 3%O(2)/97%N(2), and air, were 133, 87, and 48, respectively.	Oxygen	39-43	polyphenol oxidase, chloroplastic	Malus domestica	30-33
21535678-4	2011	Km(app) values (mM) for apple PPO in 3%O(2)/97%Ar, 3%O(2)/97%N(2), and air, were 133, 87, and 48, respectively.	Oxygen	53-57	polyphenol oxidase, chloroplastic	Malus domestica	30-33
21811636-5	2011	Vhl gene inactivation rapidly resulted in a marked splenomegaly and skin erythema, accompanied by renal and hepatic induction of the erythropoietin (Epo) gene, indicative of the in vivo activation of the oxygen sensing HIF pathway.	Oxygen	204-210	von Hippel-Lindau tumor suppressor	Mus musculus	0-3
21811636-8	2011	Thus, as well as demonstrating the potential of dietary tamoxifen administration for gene inactivation studies in UBC-Cre-ER(T2) mouse lines, this data provides evidence of a cardiac oxygen-sensing VHL/HIF/EPO pathway in adult mice.	Oxygen	183-189	ubiquitin C	Mus musculus	114-117
21151608-9	2010	CONCLUSIONS: The use of 100% oxygen for resuscitation resulted in increased potentially harmful proteolytic activities and attenuated BDNF activity when compared with 21%.	Oxygen	29-35	brain derived neurotrophic factor	Homo sapiens	134-138
21069992-5	2010	Deprotection of the C-7 oxygen function to the corresponding naphthol allows tautomerization to cyclohepta[de]naphthalene-1-ones upon seven-membered-ring closure in most cases, and replacement of the C-2 oxygen function in the naphthalene by a methyl group ultimately allows the synthesis of (+-)-microstegiol.	Oxygen	24-30	complement C7	Homo sapiens	20-23
21069992-5	2010	Deprotection of the C-7 oxygen function to the corresponding naphthol allows tautomerization to cyclohepta[de]naphthalene-1-ones upon seven-membered-ring closure in most cases, and replacement of the C-2 oxygen function in the naphthalene by a methyl group ultimately allows the synthesis of (+-)-microstegiol.	Oxygen	204-210	complement C7	Homo sapiens	20-23
20473639-4	2010	Glucose-6-phosphate dehydrogenase was lowest in log-phase cells exposed to different oxygen tensions for 24 h and in senescent cells.	Oxygen	85-91	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
20930171-3	2010	METHODS AND RESULTS: Oxygen tension in the thrombus was negatively correlated with HIF1alpha levels (Spearman correlation [RS] = -0.77, P&lt;0.0001), whereas HIF1alpha levels positively correlated with vascular endothelial growth factor (VEGF) expression (Pearson correlation [R] = 0.85, P&lt;0.0005), during resolution in a murine model.	Oxygen	21-27	vascular endothelial growth factor A	Mus musculus	202-236
20930171-3	2010	METHODS AND RESULTS: Oxygen tension in the thrombus was negatively correlated with HIF1alpha levels (Spearman correlation [RS] = -0.77, P&lt;0.0001), whereas HIF1alpha levels positively correlated with vascular endothelial growth factor (VEGF) expression (Pearson correlation [R] = 0.85, P&lt;0.0005), during resolution in a murine model.	Oxygen	21-27	vascular endothelial growth factor A	Mus musculus	238-242
20817051-2	2010	Under these circumstances, VEGF production appears to be driven by low oxygen tension, under the control of the hypoxia-inducible factor-alpha family of transcription factors (HIF-alpha).	Oxygen	71-77	vascular endothelial growth factor A	Mus musculus	27-31
20839305-3	2010	The dissociation of O(2) on Al(13)(-) is strongly dependent on spin state of oxygen molecule.	Oxygen	20-24	spindlin 1	Homo sapiens	63-67
20839305-3	2010	The dissociation of O(2) on Al(13)(-) is strongly dependent on spin state of oxygen molecule.	Oxygen	77-83	spindlin 1	Homo sapiens	63-67
20839305-5	2010	The transform of spin moment from O(2) to Al(13)(-) is much faster.	Oxygen	34-38	spindlin 1	Homo sapiens	17-21
21231324-0	2010	Observation and destruction of an elusive adsorbate with STM: O2/TiO2(110).	Oxygen	62-64	sulfotransferase family 1A member 3	Homo sapiens	57-60
21231324-4	2010	The adsorbed O2 easily dissociates during the STM measurements, and the formation of O(ad)"s at both sides of the original V(O) is observed.	Oxygen	13-15	sulfotransferase family 1A member 3	Homo sapiens	46-49
20655882-4	2010	While the exact function of the PBR remains a matter of debate, it has been implicated in heme and steroid synthesis, cellular growth and differentiation, oxygen consumption and apoptosis.	Oxygen	155-161	translocator protein	Homo sapiens	32-35
20833896-8	2010	These results clearly indicate that Crr1 is involved in the transcriptional regulation of the FDX5 gene in the absence of oxygen or copper.	Oxygen	122-128	uncharacterized protein	Chlamydomonas reinhardtii	36-40
20622111-0	2010	Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes.	Oxygen	34-40	pannexin 1	Homo sapiens	0-10
20622111-5	2010	Here we demonstrate that three structurally dissimilar compounds known to inhibit pannexin 1 prevent ATP release in response to lowered O(2) tension but not to iloprost-induced ATP release.	Oxygen	136-140	pannexin 1	Homo sapiens	82-92
20622111-6	2010	These results suggest that pannexin 1 is the conduit for ATP release from erythrocytes in response to lowered O(2) tension.	Oxygen	110-114	pannexin 1	Homo sapiens	27-37
20605749-3	2010	As well as some parameters important in the optimization studies such as optimum pH, enzyme loading and AuNP amount, the analytical characteristics of the biosensor (AuNP/GOx) were examined by the monitoring of chronoamperometric response due to the oxygen consumption through the enzymatic reaction at -0.7 V under optimized conditions at sodium acetate buffer (50 mM, pH 4.0) and the linear graph was obtained in the range of 0.1-1.0 mM glucose.	Oxygen	250-256	hydroxyacid oxidase 1	Homo sapiens	171-174
20689064-7	2010	In an oxygen-induced retinopathy model, we demonstrate that Notch3 is induced in hypoxia and interestingly, pathological neovascularization is decreased in retinas of Notch3-null mice.	Oxygen	6-12	notch 3	Mus musculus	60-66
20689064-7	2010	In an oxygen-induced retinopathy model, we demonstrate that Notch3 is induced in hypoxia and interestingly, pathological neovascularization is decreased in retinas of Notch3-null mice.	Oxygen	6-12	notch 3	Mus musculus	167-173
20485382-5	2010	Transduced cells plated in methylcellulose in hypoxia with NAC showed increased colony formation compared with 21% oxygen without NAC (P&lt;0.03), showed increased resistance to mitomycin C compared with green fluorescent protein (GFP) vector-transduced controls (P&lt;0.007), and increased survival.	Oxygen	115-121	X-linked Kx blood group	Homo sapiens	59-62
20707336-2	2010	It was found that the oxygen content in Bi(3)Mn(3)O(11+delta) can vary over a wide delta range, keeping the same cubic structure (space group Pn3, a = 9.12172(5) A for delta = -0.5, a = 9.13784(8) A for delta = 0, and a = 9.09863(7) A for delta = 0.6) and semiconducting properties of the material.	Oxygen	22-28	sodium voltage-gated channel alpha subunit 10	Homo sapiens	142-145
20677761-5	2010	Cells with reduced expression of LRPPRC had a reduction in oxygen consumption.	Oxygen	59-65	leucine rich pentatricopeptide repeat containing	Homo sapiens	33-39
20666987-11	2010	More importantly, it demonstrated that aerobic rhodococci are able to degrade RDX under a broader range of oxygen concentrations than previously reported.	Oxygen	107-113	radixin	Homo sapiens	78-81
20675541-4	2010	By a dynamic cycle, in which a decrease in tissue O(2) tension drives the conversion of Mb from being a NO scavenger under normoxia to a NO producer during hypoxia, mitochondrial respiration is reversibly adapted to the intracellular O(2) tension.	Oxygen	50-54	myoglobin	Mus musculus	88-90
20675541-4	2010	By a dynamic cycle, in which a decrease in tissue O(2) tension drives the conversion of Mb from being a NO scavenger under normoxia to a NO producer during hypoxia, mitochondrial respiration is reversibly adapted to the intracellular O(2) tension.	Oxygen	234-238	myoglobin	Mus musculus	88-90
20675541-5	2010	Therefore, Mb may act as an important O(2) sensor through which NO can regulate muscle energetics and function.	Oxygen	38-42	myoglobin	Mus musculus	11-13
20675541-6	2010	As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes of "artificial" (myo(-/-) mice) and "natural" Mb knockouts (icefish and amphibians).	Oxygen	54-60	myoglobin	Mus musculus	3-5
20675541-6	2010	As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes of "artificial" (myo(-/-) mice) and "natural" Mb knockouts (icefish and amphibians).	Oxygen	54-60	myoglobin	Mus musculus	92-94
20675541-6	2010	As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes of "artificial" (myo(-/-) mice) and "natural" Mb knockouts (icefish and amphibians).	Oxygen	54-60	myoglobin	Mus musculus	92-94
20698784-4	2010	IVF embryos that consumed &gt;0.81 x 10(14)/mol sec(-1) of oxygen at D5BL exhibited significantly higher hatching and hatched rates at D7BL, whereas D5BL SCNT embryos using porcine fetal fibroblasts did not show an increase in oxygen consumption until D7BL.	Oxygen	59-65	secretory blood group 1, pseudogene	Homo sapiens	48-54
20075058-7	2010	In CBD, associations were found with decline in forced expiratory volume in 1 s and forced vital capacity and the CCR5 -3458 thymidine (T)T genotype (p&lt;0.0001), and an increase in alveolar-arterial oxygen tension difference at rest (p = 0.003) and at maximum exercise (p = 0.01) and the -5663 adenine allele.	Oxygen	201-207	C-C motif chemokine receptor 5	Homo sapiens	114-118
20237249-5	2010	METHODS: VEGF-A(165)b was injected intraocularly in a mouse model of retinal neovascularization (oxygen-induced retinopathy [OIR]).	Oxygen	97-103	vascular endothelial growth factor A	Mus musculus	9-15
20586415-1	2010	Enzyme-mediated redox chain initiation involving glucose oxidase (GOX) was employed in an iterative solution dip-coating technique to polymerize multiple, three-dimensional hydrogel layers using mild aqueous conditions at ambient temperature and oxygen levels.	Oxygen	246-252	hydroxyacid oxidase 1	Homo sapiens	49-64
20586415-1	2010	Enzyme-mediated redox chain initiation involving glucose oxidase (GOX) was employed in an iterative solution dip-coating technique to polymerize multiple, three-dimensional hydrogel layers using mild aqueous conditions at ambient temperature and oxygen levels.	Oxygen	246-252	hydroxyacid oxidase 1	Homo sapiens	66-69
20541640-5	2010	When ferrocene monocarboxylic acid (FMCA) was introduced as diffusional electron mediator, the current responses toward glucose of the Nafion/GOx/SWCNT electrodes in glucose solution containing FMCA were dramatically improved, and the developed sensor was independent of oxygen.	Oxygen	271-277	hydroxyacid oxidase 1	Homo sapiens	142-145
20481591-2	2010	The annulation is believed to proceed via (1) oxidative addition of the aryl iodide to Pd(0), (2) syn-addition of the resulting arylpalladium complex to the 1,3-diene, (3) intramolecular coordination of the phenolic oxygen to the Pd center, (4) hydrolysis of the acetyl group, and (5) reductive elimination of Pd(0), which regenerates the catalyst.	Oxygen	216-222	synemin	Homo sapiens	98-101
20471072-4	2010	Using these cell lines, we demonstrate that (1) differentiation of hESCs induces random XCI in a manner similar to murine ESCs, (2) chronic exposure to atmospheric oxygen is sufficient to induce irreversible XCI with minor changes of the transcriptome, (3) the Xa exhibits heavy methylation of the XIST promoter region, and (4) XCI is associated with demethylation and transcriptional activation of XIST along with H3K27-me3 deposition across the Xi.	Oxygen	164-170	inactive X specific transcripts	Mus musculus	298-302
20471072-4	2010	Using these cell lines, we demonstrate that (1) differentiation of hESCs induces random XCI in a manner similar to murine ESCs, (2) chronic exposure to atmospheric oxygen is sufficient to induce irreversible XCI with minor changes of the transcriptome, (3) the Xa exhibits heavy methylation of the XIST promoter region, and (4) XCI is associated with demethylation and transcriptional activation of XIST along with H3K27-me3 deposition across the Xi.	Oxygen	164-170	inactive X specific transcripts	Mus musculus	399-403
19819434-2	2010	The G6PD inhibitor DHEA and the inhibitors of NADPH oxidase apocynin and diphenylene iodonium (DPI) prevented both superoxide generation and capacitation in human spermatozoa, but whereas DPI and DHEA inhibited PPP, apocynin did not influence it, suggesting that PPP activation during capacitation is not a response to increased oxidative stress but exerts a role by supplying reducing equivalents to oxygen.	Oxygen	401-407	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
20412331-7	2010	RESULTS: Exposure of Kupffer cells isolated from control mice to 1% oxygen activated hypoxia-inducible factor-1alpha, and increased mRNA levels of platelet-derived growth factor-B, vascular endothelial growth factor, angiopoietin-1 and monocyte chemotactic protein-1.	Oxygen	68-74	chemokine (C-C motif) ligand 2	Mus musculus	236-266
20149740-5	2010	Here, we review the emerging role of SIRT1 as a metabolic sensor coupling energy and oxygen homeostasis to the growth and function of the vasculature.	Oxygen	85-91	sirtuin 1	Homo sapiens	37-42
19285353-5	2010	RESULTS: Patients with elevated CA125 (n=65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher.	Oxygen	133-139	mucin 16, cell surface associated	Homo sapiens	32-37
20450556-7	2010	The changes of SCF/c-kit R mRNA expression in hypoxic neurons treated with different concentrations of naloxone pre and post oxygen-glucose deprivation were determined with RT-PCR.	Oxygen	125-131	KIT ligand	Homo sapiens	15-18
20204208-1	2010	The spontaneous addition of air oxygen to a dienolic compound, yielding a cyclic peroxide, was followed by spin trapping (ST) combined with EPR spectroscopy and mass spectrometry (MS).	Oxygen	32-38	spindlin 1	Homo sapiens	107-111
20034963-5	2010	Exposure of AEC to 80% oxygen/5% CO(2) for 48 h did not induce overt toxicity, but resulted in significantly decreased GM-CSF protein and mRNA expression compared with cells in normoxia.	Oxygen	23-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	119-125
19861159-2	2010	Oxygen-dependency is maintained by prolyl- and asparagyl-4-hydroxylases (PHDs/FIH-1) belonging to the superfamily of iron(II) and 2-oxoglutarate dependent dioxygenases.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	78-83
19818783-2	2010	Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia.	Oxygen	12-18	egl-9 family hypoxia-inducible factor 2	Mus musculus	26-60
19818783-2	2010	Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia.	Oxygen	12-18	egl-9 family hypoxia-inducible factor 2	Mus musculus	62-66
19818783-10	2010	Mechanistically, loss of PHD1 decreased production of oxidative stress, which likely relates to a decrease in oxygen consumption as a result of a reprogramming of hepatocellular metabolism.	Oxygen	110-116	egl-9 family hypoxia-inducible factor 2	Mus musculus	25-29
20229760-7	2010	Her oxygen saturation by pulse oxymeter (Sp(O2)) showed 78-82% in room air.	Oxygen	4-10	immunoglobulin kappa variable 1D-39	Homo sapiens	41-46
21053474-11	2010	This case report suggests the efficacy of noninvasive titrating of CPAP level by the hemoglobin oxygen saturation trend measurement.	Oxygen	96-102	centromere protein J	Homo sapiens	67-71
20426956-0	2010	[Effects of hyperbaric oxygen on synaptic ultrastructure and synaptophysin expression in hippocampus of neonatal rats with hypoxic-ischemic brain damage].	Oxygen	23-29	synaptophysin	Rattus norvegicus	61-74
20102231-0	2010	PdCl2(HNMe2)2-catalyzed highly selective cross [2 + 2 + 2] cyclization of alkynoates and alkenes under molecular oxygen.	Oxygen	113-119	phosducin like 2	Homo sapiens	0-5
19607941-2	2010	The surface properties of the Ar/H(2) and Ar/O(2) in series AP-treated PES films showed higher surface roughness (approximately 120%), surface energy (approximately 30%) and hydrophilic properties (oxygen content approximately 10%) than the Ar/O(2) AP-treated PES film.	Oxygen	198-204	ADP-ribosylhydrolase like 1	Homo sapiens	30-37
20052410-8	2010	The differentiation assays showed that the percentages of beta-tubIII+ or MAP2+ neuronal cells and of GalC+ oligodendrocytes were significantly higher at 2.5% compared with 1, 5, or 20% oxygen at 17 days in vitro.	Oxygen	186-192	microtubule associated protein 2	Homo sapiens	58-78
20052410-9	2010	Mild hypoxia (2.5 to 5% oxygen) promoted differentiation into neuro-oligodendroglial progenitors as revealed by the higher percentage of MAP2+/Ki67+ and GalC+/Ki67+ residual proliferating progenitors, and enhanced the yield of GABAergic and slightly of glutamatergic neurons compared to 1% and 20% oxygen where a significant percentage of GFAP+/nestin+ cells were still present at 17 days of differentiation.	Oxygen	24-30	microtubule associated protein 2	Homo sapiens	137-141
20052410-9	2010	Mild hypoxia (2.5 to 5% oxygen) promoted differentiation into neuro-oligodendroglial progenitors as revealed by the higher percentage of MAP2+/Ki67+ and GalC+/Ki67+ residual proliferating progenitors, and enhanced the yield of GABAergic and slightly of glutamatergic neurons compared to 1% and 20% oxygen where a significant percentage of GFAP+/nestin+ cells were still present at 17 days of differentiation.	Oxygen	24-30	galactosylceramidase	Homo sapiens	153-157
19812919-0	2010	Reduced matrix metalloproteinase-9 activity and cell death after global ischemia in the brain preconditioned with hyperbaric oxygen.	Oxygen	125-131	matrix metallopeptidase 9	Rattus norvegicus	8-34
19889962-9	2010	day(-1)) inhibited mRNA and protein expression of TRPC1 and TRPC6 in PA from chronically hypoxic (10% O2 for 21 days) rats, which was associated with decreased right ventricular pressure and right ventricular hypertrophy.	Oxygen	102-104	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	50-55
19889962-9	2010	day(-1)) inhibited mRNA and protein expression of TRPC1 and TRPC6 in PA from chronically hypoxic (10% O2 for 21 days) rats, which was associated with decreased right ventricular pressure and right ventricular hypertrophy.	Oxygen	102-104	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	60-65
20028863-6	2010	Gain and loss of function experiments defined PHD2 and PHD3 as HIF target genes that remained operative even at low oxygen concentrations.	Oxygen	116-122	egl-9 family hypoxia inducible factor 3	Homo sapiens	55-59
20054152-7	2010	The transcription factor CREB (cAMP response element binding protein) was activated with decreasing oxygen tensions in both cell types.	Oxygen	100-106	cAMP responsive element binding protein 1	Homo sapiens	25-29
20054152-7	2010	The transcription factor CREB (cAMP response element binding protein) was activated with decreasing oxygen tensions in both cell types.	Oxygen	100-106	cAMP responsive element binding protein 1	Homo sapiens	31-68
21095465-8	2010	Other properties of COMT inhibitors, like scavenging of oxygen and nitrogen radicals, may be important in antiallodynic effects found in neuropathic pain models.	Oxygen	56-62	catechol-O-methyltransferase	Mus musculus	20-24
20414335-1	2010	Erythropoietin (Epo) and vascular growth factor (VEGF) are known to be involved in the regulation of cellular activity when oxygen transport is reduced as in anaemia or hypoxic conditions.	Oxygen	124-130	vascular endothelial growth factor A	Mus musculus	49-53
19795395-7	2010	However, at 40 +/- 4 fmol cell(-1) h(-1) the oxygen consumption by chondrocytes expanded under 2% oxygen for 14 days was still 14 times the value observed for freshly isolated cells.	Oxygen	45-51	carboxyl ester lipase pseudogene	Homo sapiens	26-33
19795395-7	2010	However, at 40 +/- 4 fmol cell(-1) h(-1) the oxygen consumption by chondrocytes expanded under 2% oxygen for 14 days was still 14 times the value observed for freshly isolated cells.	Oxygen	98-104	carboxyl ester lipase pseudogene	Homo sapiens	26-33
19801500-7	2010	In adherent neutrophils, TNF triggered a time-dependent association of delta-PKC with p47phox, which was associated with p47phox phosphorylation, indicating a role for delta-PKC in regulating O(2)(-) production at the level of p47phox.	Oxygen	192-197	neutrophil cytosolic factor 1	Homo sapiens	86-93
21387795-3	2010	A molecule of methemoglobin is incapable of binding and carrying of oxygen.	Oxygen	68-74	hemoglobin subunit gamma 2	Homo sapiens	14-27
21387795-7	2010	Cyanosis resistant to oxygen therapy and dyspnea occur in patients with the methemoglobin concentration above 20%.	Oxygen	22-28	hemoglobin subunit gamma 2	Homo sapiens	76-89
19632787-4	2010	Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment.	Oxygen	39-45	oxytocin/neurophysin I prepropeptide	Homo sapiens	272-275
20369468-3	2010	Hypoxia-inducible factor-1alpha (HIF-1alpha), a master regulator of oxygen homeostasis was measured as a marker of hypoxic status.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
20369468-3	2010	Hypoxia-inducible factor-1alpha (HIF-1alpha), a master regulator of oxygen homeostasis was measured as a marker of hypoxic status.	Oxygen	68-74	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
19919085-1	2009	Neuroglobin (Ngb), a recently discovered member of the globin family, is overexpressed in the brain tissues over oxygen deprivation.	Oxygen	113-119	neuroglobin	Homo sapiens	0-11
19919085-1	2009	Neuroglobin (Ngb), a recently discovered member of the globin family, is overexpressed in the brain tissues over oxygen deprivation.	Oxygen	113-119	neuroglobin	Homo sapiens	13-16
19919085-5	2009	We have studied the diffusion of small ligands (CO, NO, and O(2)) in the globin internal cavity network for various states of human Ngb.	Oxygen	60-64	neuroglobin	Homo sapiens	132-135
19860834-8	2009	Furthermore, Ngb reversibly binds oxygen at acidic pH, with an affinity that increases as the pH is decreased.	Oxygen	34-40	neuroglobin	Homo sapiens	13-16
19762521-7	2009	Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood.	Oxygen	26-30	killer cell lectin like receptor G1	Homo sapiens	239-244
20045920-1	2009	OBJECTIVE: To observe the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in hippocampus neurons in rats after different time of neuron oxygen deprivation/oxygen supply, and to investigate the role of PPARgamma in neuron ischemia reperfusion injury.	Oxygen	182-188	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	40-88
20045920-1	2009	OBJECTIVE: To observe the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in hippocampus neurons in rats after different time of neuron oxygen deprivation/oxygen supply, and to investigate the role of PPARgamma in neuron ischemia reperfusion injury.	Oxygen	182-188	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	90-99
20045920-7	2009	The expression of PPARgamma was decreased both at mRNA and protein level after 6 h of oxygen supply.	Oxygen	86-92	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	18-27
19896443-5	2009	Identification of the FoxO3-dependent gene expression profile in NSCs suggests that FoxO3 regulates the NSC pool by inducing a program of genes that preserves quiescence, prevents premature differentiation, and controls oxygen metabolism.	Oxygen	220-226	forkhead box O3	Mus musculus	22-27
19896443-5	2009	Identification of the FoxO3-dependent gene expression profile in NSCs suggests that FoxO3 regulates the NSC pool by inducing a program of genes that preserves quiescence, prevents premature differentiation, and controls oxygen metabolism.	Oxygen	220-226	forkhead box O3	Mus musculus	84-89
19244202-2	2009	The present studies tested the hypothesis that exposure to 85% O2 negatively impacts the Trx1 system and VEGF expression in the lungs of newborn mice.	Oxygen	63-65	thioredoxin 1	Mus musculus	89-93
19244202-2	2009	The present studies tested the hypothesis that exposure to 85% O2 negatively impacts the Trx1 system and VEGF expression in the lungs of newborn mice.	Oxygen	63-65	vascular endothelial growth factor A	Mus musculus	105-109
19244202-3	2009	There was no effect of fraction of inspired oxygen on lung Trx1 or Trx reductase-1 protein levels; however, lung Trx1 protein was predominantly oxidized in the lungs of newborn mice exposed to 85% O2 by 24 hours of exposure.	Oxygen	197-199	thioredoxin 1	Mus musculus	113-117
19277739-0	2009	Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana.	Oxygen	54-60	P4H 	Arabidopsis thaliana	0-20
19277739-0	2009	Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana.	Oxygen	54-60	P4H 	Arabidopsis thaliana	22-28
19737748-1	2009	Oxygen is critically important to metazoan life, and the EGL-9/PHD enzymes are key regulators of hypoxia (low oxygen) response.	Oxygen	110-116	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	57-62
19737748-2	2009	When oxygen levels are high, the EGL-9/PHD proteins hydroxylate hypoxia-inducible factor (HIF) transcription factors.	Oxygen	5-11	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	33-38
19737748-11	2009	In addition to its well-established role as the oxygen sensor that regulates HIF-1 protein levels, EGL-9 inhibits HIF-1 transcriptional activity via a pathway that has little or no requirement for hydroxylase activity or for the EGL-9 MYND domain.	Oxygen	48-54	Hypoxia-inducible factor prolyl hydroxylase	Caenorhabditis elegans	99-104
19419319-0	2009	Oxygen tension regulates the expression of ANK (progressive ankylosis) in an HIF-1-dependent manner in growth plate chondrocytes.	Oxygen	0-6	progressive ankylosis	Mus musculus	43-46
19419319-1	2009	The proximal promoter region of ANK, a gene that codes for a protein that regulates the transport of inorganic pyrophosphate, contains two hypoxia responsive elements (HREs); therefore, we studied the expression and function of ANK at different oxygen tensions.	Oxygen	245-251	progressive ankylosis	Mus musculus	32-35
19419319-8	2009	Expression of ANK in growth plate and articular cartilage was low in hypoxic regions of the tissues, and higher levels of ANK expression were observed in the synovium and meniscus in regions that have a normally higher oxygen tension.	Oxygen	219-225	progressive ankylosis	Mus musculus	14-17
19883226-8	2009	Our results confirm that treatment with an inhibitor of VEGFR signaling reduces oxygen consumption rate by tumor cells.	Oxygen	80-86	kinase insert domain receptor	Homo sapiens	56-61
19443721-6	2009	RESULTS: PAI-1 expression was upregulated in the retinas of mice with oxygen-induced retinopathy, which coincided with a significant increase in the expression of vitronectin in the retina of the experimental mice.	Oxygen	70-76	vitronectin	Mus musculus	163-174
19712978-1	2009	Ec DOS is a heme-based gas sensor enzyme that catalyzes conversion from cyclic-di-GMP to linear-di-GMP in response to gas molecules, such as oxygen, CO and NO.	Oxygen	141-147	5'-nucleotidase, cytosolic II	Homo sapiens	82-85
19712978-1	2009	Ec DOS is a heme-based gas sensor enzyme that catalyzes conversion from cyclic-di-GMP to linear-di-GMP in response to gas molecules, such as oxygen, CO and NO.	Oxygen	141-147	5'-nucleotidase, cytosolic II	Homo sapiens	99-102
19670369-4	2009	The upregulation of Grp78 suggested that ER stress proteins were altered and indeed Grp94 and caspase 12 expression were increased in cells exposed to 5% O(2).	Oxygen	154-158	heat shock protein 90 beta family member 1	Homo sapiens	84-89
19670369-6	2009	Exposure to 1% O(2) caused increases in cofilin-1, cyclophilin A, and caspase 12 as well as a decrease of beta-actin, but it did not alter the expression of calmodulin, tubulin, Grp78, and Grp94.	Oxygen	15-19	POTE ankyrin domain family member F	Homo sapiens	106-116
19670369-6	2009	Exposure to 1% O(2) caused increases in cofilin-1, cyclophilin A, and caspase 12 as well as a decrease of beta-actin, but it did not alter the expression of calmodulin, tubulin, Grp78, and Grp94.	Oxygen	15-19	heat shock protein 90 beta family member 1	Homo sapiens	189-194
19670369-8	2009	The present investigations reveal that lowering O(2), probably in part through hypoxia-inducible factor, alter the expression of a series of proteins mainly involved in cytoskeletal changes (e.g. cofilin-1, tubulin, and beta-actin) and in ER stress/apoptosis (e.g. Grp78/94, caspase 12, and cyclophilin A).	Oxygen	48-52	POTE ankyrin domain family member F	Homo sapiens	220-230
19753307-7	2009	Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.	Oxygen	82-88	solute carrier family 25 member 19	Homo sapiens	30-64
19745547-2	2009	To fabricate a GOx layer by applying cross-linking chemistries, the PDMS layer was treated with oxygen plasma to replace silane groups with silanol groups.	Oxygen	96-102	hydroxyacid oxidase 1	Homo sapiens	15-18
19393735-8	2009	The introduction of oxygen to the gasifier strengthened the gasification and improved the carbon conversion, but lowered the lower heating value and the H2/CO ratio of the syngas.	Oxygen	20-26	relaxin 2	Homo sapiens	153-158
19714248-5	2009	METHODOLOGY/PRINCIPAL FINDINGS: Upon exposure of colon and lung cancer cells to hypoxia, by either low oxygen or cobalt, HIPK2 function was impaired allowing for increased HIF-1alpha expression and inhibiting the p53-apoptotic response to drug.	Oxygen	103-109	homeodomain interacting protein kinase 2	Homo sapiens	121-126
19639147-4	2009	This exchangeable oxygen atom is not observed in the ESEEM spectra of the Y236F mutant of SDH, where the active site tyrosine has been replaced by phenylalanine.	Oxygen	18-24	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	90-93
19584355-0	2009	Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.	Oxygen	0-6	adrenoceptor beta 2	Homo sapiens	17-44
19501525-6	2009	The second aim was to determine if the link between varying levels of the cytokine, IL-10, and the expression/release of TNF-alpha was oxygen dependent, and whether there was a concurrent change in sFlt-1.	Oxygen	135-141	interleukin 10	Homo sapiens	84-89
19501525-9	2009	RESULTS: Placental IL-10 release was significantly reduced at 2% oxygen when compared to 8% (p=0.045) and 21% (p=0.013).	Oxygen	65-71	interleukin 10	Homo sapiens	19-24
19501525-11	2009	Exogenous IL-10 significantly reduced TNF-alpha protein levels only when explants were cultured in 2% oxygen (p=0.05).	Oxygen	102-108	interleukin 10	Homo sapiens	10-15
19233690-6	2009	Gene Ontology analysis indicated a significant alteration of oxygen transport (increased hemoglobin gene expression) and lipid metabolism [including monoglyceride lipase and low density lipoprotein receptor-related protein 5 (LRP5) gene].	Oxygen	61-67	monoglyceride lipase	Homo sapiens	149-169
19570752-4	2009	Twelve participants randomized to auto-CPAP (3 with oxygen) showed improvement in Apnea/Hypopnea Index (p&lt;0.001), average desaturation events &gt;3%/hour (p=0.02), mean nocturnal SpO(2) (p=0.02) and cognition.	Oxygen	52-58	centromere protein J	Homo sapiens	39-43
19457091-1	2009	Neuroglobin (Ngb) is an oxygen binding heme protein found in nervous tissue with a yet unclear physiological and protective role in the hypoxia-sensitive mammalian brain.	Oxygen	24-30	neuroglobin	Homo sapiens	0-11
19457091-1	2009	Neuroglobin (Ngb) is an oxygen binding heme protein found in nervous tissue with a yet unclear physiological and protective role in the hypoxia-sensitive mammalian brain.	Oxygen	24-30	neuroglobin	Homo sapiens	13-16
19799369-2	2009	Low doses of radiation induced an intensive hydrolysis of membrane phospholipids by phospholipase A2, displayed by an increase in the level of eukosanoisds--LTC4 and TxB2, formed under effects of lipid oxidases (lipoxygenase and cyclooxygenase) at the same time with O2 generation.	Oxygen	267-269	phospholipase A2, group IB, pancreas	Mus musculus	84-100
19448429-5	2009	Low oxygen levels result in strongly increased HIPK2/Siah2 interactions that lead to efficient polyubiquitylation and proteasomal degradation of the kinase.	Oxygen	4-10	homeodomain interacting protein kinase 2	Homo sapiens	47-52
19188049-11	2009	Overall results demonstrated that the mSi-PU/F127 semi-IPN hydrogel provided silicone hydrogel materials not only having relatively high oxygen permeability and a relatively low modulus, but also enhancing hydrophilicity and anti-protein adsorption.	Oxygen	137-143	phenylalkylamine Ca2+ antagonist (emopamil) binding protein	Mus musculus	38-41
20403769-1	2009	Expression level of genes associated with oxygen [cytochrome oxidase 1 (COX1) and myoglobin (Mb)] and glucose utilization [glucose transporters (GLUTs) and hexokinases (HKs)] along with metabolic indices were determined in Atlantic cod (Gadus morhua) subjected to an hypoxic challenge of &lt;45% oxygen saturation for 24 days.	Oxygen	42-48	cytochrome c oxidase subunit I	Gadus morhua	50-70
20403769-1	2009	Expression level of genes associated with oxygen [cytochrome oxidase 1 (COX1) and myoglobin (Mb)] and glucose utilization [glucose transporters (GLUTs) and hexokinases (HKs)] along with metabolic indices were determined in Atlantic cod (Gadus morhua) subjected to an hypoxic challenge of &lt;45% oxygen saturation for 24 days.	Oxygen	42-48	cytochrome c oxidase subunit I	Gadus morhua	72-76
19431004-7	2009	Part of this compensatory strategy on the TEF resulted in less muscle activity and, therefore, less demand for oxygen delivery to the calf muscle than for other surfaces.	Oxygen	111-117	TEF transcription factor, PAR bZIP family member	Bos taurus	42-45
19466639-0	2009	FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions.	Oxygen	79-85	FA complementation group D2	Homo sapiens	0-6
19466639-7	2009	However, at 0% oxygen FANCD2-deficient cells were more radiosensitive than wild-type cells.	Oxygen	15-21	FA complementation group D2	Homo sapiens	22-28
19466639-9	2009	Our data also suggest that the increased radiosensitivity of FANCD2-deficient cells seen under conditions of reduced oxygen is associated with apoptotic cell death, but not secondary to a defect in the homologous recombination repair pathway that is required for crosslink repair.	Oxygen	117-123	FA complementation group D2	Homo sapiens	61-67
19321442-1	2009	Oxygen and glucose deprivation (OGD) induces delayed cell death in hippocampal CA1 neurons via Ca(2+)/Zn(2+)-permeable, GluR2-lacking AMPA receptors (AMPARs).	Oxygen	0-6	carbonic anhydrase 1	Homo sapiens	79-82
17904251-1	2009	Oxidative stress is a relevant pathomechanism in Alzheimer"s disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD.	Oxygen	178-184	glutathione S-transferase mu 3	Homo sapiens	136-141
19203623-2	2009	To construct the biosensor tyrosinase was immobilized by using gelatine and cross-linking agent glutaraldehyde on a Clark type dissolved oxygen (DO) probe covered with a teflon membrane which is sensitive for oxygen.	Oxygen	137-143	tyrosinase	Homo sapiens	27-37
19203623-2	2009	To construct the biosensor tyrosinase was immobilized by using gelatine and cross-linking agent glutaraldehyde on a Clark type dissolved oxygen (DO) probe covered with a teflon membrane which is sensitive for oxygen.	Oxygen	209-215	tyrosinase	Homo sapiens	27-37
19518729-3	2009	The etching is activated by a second step of additional O2 adsorption at the ether groups, forming larger O groups, such as lactone (C-O-C=O) and anhydride (O=C-O-C=O), that may desorb as CO2 just above room temperature.	Oxygen	56-58	DAN domain BMP antagonist family member 5	Homo sapiens	133-140
19518729-3	2009	The etching is activated by a second step of additional O2 adsorption at the ether groups, forming larger O groups, such as lactone (C-O-C=O) and anhydride (O=C-O-C=O), that may desorb as CO2 just above room temperature.	Oxygen	56-58	DAN domain BMP antagonist family member 5	Homo sapiens	159-166
19263507-6	2009	The results indicated that mobile phone EMFs altered oxygen affinity and tertiary structure of HbA.	Oxygen	53-59	keratin 90, pseudogene	Homo sapiens	95-98
19263507-7	2009	Furthermore, the decrease of oxygen affinity of HbA corresponded to the EMFs intensity and time of exposure.	Oxygen	29-35	keratin 90, pseudogene	Homo sapiens	48-51
19098317-1	2009	PURPOSE: The transcription factor hypoxia-inducible factor (HIF)-1 plays a central physiological role in oxygen and energy homeostasis and is activated during hypoxia by stabilization of the subunit HIF-1alpha.	Oxygen	105-111	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	199-209
19214140-13	2009	This suggests that MRP2 is a determinant of the redox status in tubular epithelial cells and thus of the susceptibility to renal damage under conditions of treatment with multiple drugs and increased oxygen radical formation.	Oxygen	200-206	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
19262943-1	2009	Depending on the substitution pattern and the solvent, the gold-catalyzed cyclization of alk-4-yn-1-ones affords different oxygen heterocycles under mild reaction conditions.	Oxygen	123-129	activin A receptor type 1B	Homo sapiens	89-94
19318315-0	2009	Low O2 concentrations enhance the positive effect of IL-17 on the maintenance of erythroid progenitors during co-culture of CD34+ and mesenchymal stem cells.	Oxygen	4-6	interleukin 17A	Homo sapiens	53-58
18956302-9	2009	Hypoxia (4% O (2)) caused an approximately 36% increase of RANTES release.	Oxygen	12-17	C-C motif chemokine ligand 5	Homo sapiens	59-65
19111934-1	2009	Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a monomeric enzyme that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the phenolic oxygen of substituted catechols.	Oxygen	170-176	methionine adenosyltransferase 1A	Rattus norvegicus	121-144
19212630-2	2009	A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent.	Oxygen	88-94	C-X-C motif chemokine receptor 4	Homo sapiens	71-76
19205055-5	2009	Multivariate linear regressions demonstrated that MMP-9 levels and MMP-9/TIMP-1 ratios in the cord blood of the premature infants correlated with the oxygen supplementation period (r = 0.58, P = 0.003 and r = 0.41, P = 0.030, respectively).	Oxygen	150-156	matrix metallopeptidase 9	Homo sapiens	50-55
19267995-7	2009	Given the abundance of cytochrome c in the intermembrane space of mitochondria, the cellular location of PPO, this process may potentially impact on the synthesis of heme in vivo particularly in conditions of low oxygen or hypoxia.	Oxygen	213-219	Cytochrome c proximal	Drosophila melanogaster	23-35
19033400-1	2009	OBJECTIVE: The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.	Oxygen	140-146	von Hippel-Lindau tumor suppressor	Mus musculus	15-19
19033400-1	2009	OBJECTIVE: The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.	Oxygen	140-146	von Hippel-Lindau tumor suppressor	Mus musculus	39-64
19033400-1	2009	OBJECTIVE: The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.	Oxygen	140-146	von Hippel-Lindau tumor suppressor	Mus musculus	66-69
18985055-9	2009	Finally we subjected a rat primary neuronal culture to oxygen and glucose deprivation (OGD) and we reproduced the nuclear translocation of MMP-13 in vitro.	Oxygen	55-61	matrix metallopeptidase 13	Rattus norvegicus	139-145
19097132-3	2009	When cells were subjected to hypoxia (1% O2), the mRNA and protein levels of FoxM1 had a significant increase in cancer cells (HepG2, MCF-7, and HeLa).	Oxygen	41-43	forkhead box M1	Homo sapiens	77-82
19196431-4	2009	The early post-hypoxic up-regulation of BACE1 depends on the production of reactive oxygen species mediated by the sudden interruption of the mitochondrial electron transport chain, while the later expression of BACE1 is caused by hypoxia inducible factor 1alpha activation.	Oxygen	84-90	beta-secretase 1	Rattus norvegicus	40-45
19105697-7	2009	Crystallization of OAT2 in the presence of N-alpha-acetyl-L-glutamate led to a structure in which Thr-181 was acetylated; the carbonyl oxygen of the acyl-enzyme complex was located in an oxyanion hole and positioned to hydrogen bond with the backbone amide NH of Gly-112 and the alcohol of Thr-111.	Oxygen	135-141	solute carrier family 22 member 7	Homo sapiens	19-23
19150845-4	2009	We show that the mechanism of NPR-1-mediated pathogen resistance is through oxygen-dependent behavioral avoidance rather than direct regulation of innate immunity.	Oxygen	76-82	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	30-35
19536508-1	2009	In pulmonary neuroepithelial bodies (NEB), presumed airway chemoreceptors, classical NADPH oxidase (gp91 phox, NOX2) is co-expressed with O(2) sensitive K(+) channels (K(+)O(2)) and functions as an O(2) sensor.	Oxygen	138-142	cytochrome b-245 beta chain	Homo sapiens	111-115
18945953-11	2009	In summary, AM and HIF-1alpha expression increases in response to ureteral obstruction in agreement with expected oxygen gradients.	Oxygen	114-120	adrenomedullin	Rattus norvegicus	12-14
18945953-11	2009	In summary, AM and HIF-1alpha expression increases in response to ureteral obstruction in agreement with expected oxygen gradients.	Oxygen	114-120	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	19-29
18815358-0	2009	Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
18815358-0	2009	Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen.	Oxygen	111-117	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-38
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	21-52
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	54-59
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	4-10	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	152-157
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	21-52
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	54-59
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	21-52
18815358-4	2009	The oxygen-sensitive hypoxia-inducible factor 1alpha (HIF1A) is a major transcriptional regulator of the cellular response to low oxygen, and increased HIF1A protein levels and activity corresponded with the maintenance of the stem cell-like state and inhibition of trophoblast differentiation in low oxygen.	Oxygen	130-136	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	54-59
18815358-5	2009	Furthermore, constitutive expression of an oxygen-insensitive, active form of HIF1A protein mimicked the effects of low oxygen, inhibiting the differentiation of trophoblast giant cells.	Oxygen	43-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	78-83
18815358-5	2009	Furthermore, constitutive expression of an oxygen-insensitive, active form of HIF1A protein mimicked the effects of low oxygen, inhibiting the differentiation of trophoblast giant cells.	Oxygen	120-126	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	78-83
18815358-7	2009	In addition, this is the first reported study to demonstrate that constitutive HIF1A activity mediates oxygen"s inhibition of differentiation.	Oxygen	103-109	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	79-84
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	6-8	sirtuin 1	Homo sapiens	48-53
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	6-8	sirtuin 1	Homo sapiens	77-82
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	6-8	sirtuin 1	Homo sapiens	77-82
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	116-118	sirtuin 1	Homo sapiens	77-82
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	116-118	sirtuin 1	Homo sapiens	77-82
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	116-118	sirtuin 1	Homo sapiens	77-82
18922599-6	2009	Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.	Oxygen	116-118	sirtuin 1	Homo sapiens	77-82
19321927-8	2009	ASCT2 mRNA levels were preserved at normoxia and downregulated at 1% O(2) after 48 h. CONCLUSION: Our data support the premise that the expression of GCMa and syncytin-1 precedes syncytialization of trophoblasts, e.g. at 6% O(2), which is assumed to resemble physiological conditions.	Oxygen	69-73	solute carrier family 1 member 5	Homo sapiens	0-5
19321927-8	2009	ASCT2 mRNA levels were preserved at normoxia and downregulated at 1% O(2) after 48 h. CONCLUSION: Our data support the premise that the expression of GCMa and syncytin-1 precedes syncytialization of trophoblasts, e.g. at 6% O(2), which is assumed to resemble physiological conditions.	Oxygen	224-228	solute carrier family 1 member 5	Homo sapiens	0-5
19321927-8	2009	ASCT2 mRNA levels were preserved at normoxia and downregulated at 1% O(2) after 48 h. CONCLUSION: Our data support the premise that the expression of GCMa and syncytin-1 precedes syncytialization of trophoblasts, e.g. at 6% O(2), which is assumed to resemble physiological conditions.	Oxygen	224-228	glial cells missing transcription factor 1	Homo sapiens	150-154
18711728-1	2009	Neuroglobin (Ngb) is a recently discovered tissue globin with a high affinity for oxygen that is widely and specifically expressed in neurons of vertebrate central and peripheral nervous systems.	Oxygen	82-88	neuroglobin	Homo sapiens	0-11
18711728-1	2009	Neuroglobin (Ngb) is a recently discovered tissue globin with a high affinity for oxygen that is widely and specifically expressed in neurons of vertebrate central and peripheral nervous systems.	Oxygen	82-88	neuroglobin	Homo sapiens	13-16
18927085-5	2008	Our data suggest that Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization.	Oxygen	82-88	potassium voltage-gated channel subfamily H member 1	Homo sapiens	22-26
18940239-6	2008	Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.	Oxygen	10-16	neuroglobin	Homo sapiens	94-105
18922957-0	2008	Differential regulation of AMP-activated kinase and AKT kinase in response to oxygen availability in crucian carp (Carassius carassius).	Oxygen	78-84	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	27-47
18922957-2	2008	We report that phosphorylation of AMPK and AKT in heart and brain showed small changes after 10 days of severe hypoxia (0.3 mg O2/l at 9 degrees C).	Oxygen	127-129	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	34-38
19076451-9	2008	Erv1 directly interacts with Mia40 and shuttles electrons from reduced Mia40 to oxidized cytochrome c, from whence they flow through cytochrome oxidase to molecular oxygen.	Oxygen	165-171	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	29-34
18815025-2	2008	The scheme is based on the measurement of the consumption of oxygen during the oxidation of uric acid that is catalyzed by the enzyme uricase.	Oxygen	61-67	urate oxidase (pseudogene)	Homo sapiens	134-141
18951789-2	2008	Reaction of 4 with thiophenol, the SH group of which has similar pK(a) value to that of cysteine protease, produced oxygen-mediated radical adducts 6 and 7 in ambient air but did not proceed under oxygen-free conditions.	Oxygen	116-122	cathepsin B	Homo sapiens	88-105
18951789-4	2008	These results suggest that cysteine protease can act through an oxygen-dependent radical mechanism.	Oxygen	64-70	cathepsin B	Homo sapiens	27-44
19001187-11	2008	Unilateral renal infusion of the PKCalpha inhibitor Go6976 reduced furosemide-sensitive oxygen consumption (37.4+/-1.5% versus 25.1+/-1.0% of total oxygen consumption; P&lt;0.01) in hypertensive rats.	Oxygen	88-94	protein kinase C, alpha	Rattus norvegicus	33-41
19001187-11	2008	Unilateral renal infusion of the PKCalpha inhibitor Go6976 reduced furosemide-sensitive oxygen consumption (37.4+/-1.5% versus 25.1+/-1.0% of total oxygen consumption; P&lt;0.01) in hypertensive rats.	Oxygen	148-154	protein kinase C, alpha	Rattus norvegicus	33-41
19001187-12	2008	We conclude that Ang II-dependent hypertension enhances thick ascending limb Na transport-related oxygen consumption by increasing O(2)(-) and PKCalpha activity.	Oxygen	98-104	angiogenin	Rattus norvegicus	17-20
19001187-12	2008	We conclude that Ang II-dependent hypertension enhances thick ascending limb Na transport-related oxygen consumption by increasing O(2)(-) and PKCalpha activity.	Oxygen	98-104	protein kinase C, alpha	Rattus norvegicus	143-151
18838541-0	2008	Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.	Oxygen	128-134	coagulation factor XII	Homo sapiens	0-25
18838541-3	2008	Here, we describe a new regulator of HIF-1alpha, the hypoxia-associated factor (HAF), a novel E3-ubiquitin ligase that binds HIF-1alpha leading to its proteasome-dependent degradation irrespective of cellular oxygen tension.	Oxygen	209-215	coagulation factor XII	Homo sapiens	53-78
18838541-3	2008	Here, we describe a new regulator of HIF-1alpha, the hypoxia-associated factor (HAF), a novel E3-ubiquitin ligase that binds HIF-1alpha leading to its proteasome-dependent degradation irrespective of cellular oxygen tension.	Oxygen	209-215	coagulation factor XII	Homo sapiens	80-83
18838541-8	2008	Therefore, HAF is the key mediator of a new HIF-1alpha-specific degradation pathway that degrades HIF-1alpha through a new, oxygen-independent mechanism.	Oxygen	124-130	coagulation factor XII	Homo sapiens	11-14
18474670-6	2008	In mice subjected to low oxygen in vivo, CFTR mRNA expression in airways, gastrointestinal tissues, and liver was repressed.	Oxygen	25-31	cystic fibrosis transmembrane conductance regulator	Mus musculus	41-45
18778796-2	2008	In this context, particular attention is given to the reactions of small molecules such as dioxygen, carbon monoxide, and nitric oxide with selected hemoproteins (hemoglobin, myoglobin, neuroglobin and cytochrome P450(cam)), as well as to photo-induced electron transfer reactions occurring in hemoproteins (particularly in various types of cytochromes).	Oxygen	91-99	neuroglobin	Homo sapiens	186-197
18586877-14	2008	Increasing oxygen decreased levels of p27(KIP1) in the epithelial cells of older mice, which was prevented by expressing oxygen-insensitive forms of HIF-1alpha.	Oxygen	121-127	cyclin-dependent kinase inhibitor 1B	Mus musculus	38-41
18586877-14	2008	Increasing oxygen decreased levels of p27(KIP1) in the epithelial cells of older mice, which was prevented by expressing oxygen-insensitive forms of HIF-1alpha.	Oxygen	121-127	cyclin-dependent kinase inhibitor 1B	Mus musculus	42-46
18490920-1	2008	The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor.	Oxygen	113-119	von Hippel-Lindau tumor suppressor	Mus musculus	39-43
18565955-9	2008	Elevated levels of GDF-15 were associated with increased mean right atrial and pulmonary capillary wedge pressures, a lower mixed venous oxygen saturation (Sv(O(2))), and higher levels of uric acid and N-terminal pro-brain natriuretic peptide (NT-proBNP).	Oxygen	137-143	growth differentiation factor 15	Homo sapiens	19-25
18366089-7	2008	Following exposure of MSCs to hypoxia (2% oxygen), HIF-1alpha translocated from the cytosol to the nucleus and bound to its target DNA consensus sequence.	Oxygen	42-48	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	51-61
18366089-12	2008	This provides evidence for HIF-1alpha being a key mediator of the beneficial effect of a low oxygen environment on chondrogenesis.	Oxygen	93-99	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	27-37
18492695-4	2008	A small fall in arterial oxygen saturation and an increase in fetal heart rate for both groups can be attributed to an insulin-mediated increase in fetal metabolic rate.	Oxygen	25-31	LOC105613195	Ovis aries	119-126
18522938-4	2008	Here we show that superoxide formation at the ubiquinol oxidation center of the membrane-bound or purified cytochrome bc(1) complex is stimulated by the presence of oxidized ubiquinone indicating that in a reverse reaction the electron is transferred onto oxygen from reduced cytochrome b(L) via ubiquinone rather than during the forward ubiquinone cycle reaction.	Oxygen	256-262	mitochondrially encoded cytochrome b	Homo sapiens	107-119
18498438-6	2008	Adrenomedullin expression increased following the hypoxic period, and following OGD only in pre-conditioned (0.1% or 0.5% of O2) neurons.	Oxygen	125-127	adrenomedullin	Homo sapiens	0-14
18521186-0	2008	Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.	Oxygen	71-77	vascular endothelial growth factor A	Mus musculus	88-92
18521186-2	2008	In this process, tissue oxygen concentration is well known to determine capillary density via the hypoxia-induced cascade, in which HIFs and VEGF play key roles.	Oxygen	24-30	vascular endothelial growth factor A	Mus musculus	141-145
18406084-4	2008	At a given GP1 concentration, oxygen-containing linalool and cineole decreased gel moduli (elastic and viscous) and brittleness, and the reverse was obtained for hydrocarbon limonene.	Oxygen	30-36	GTP binding protein 1	Homo sapiens	11-14
18424433-1	2008	Oxygen-dependent ubiquitination of the alpha-subunit of hypoxia-inducible factor (HIF-alpha) by the (von Hippel-Lindau protein)-Elongin B/C-Cullin2-Rbx1 (VBC-Cul2) ubiquitin ligase, a member of the cullin-RING ubiquitin ligases (CRLs), plays a central role in controlling oxygen metabolism.	Oxygen	0-6	ring-box 1	Homo sapiens	148-152
18424433-1	2008	Oxygen-dependent ubiquitination of the alpha-subunit of hypoxia-inducible factor (HIF-alpha) by the (von Hippel-Lindau protein)-Elongin B/C-Cullin2-Rbx1 (VBC-Cul2) ubiquitin ligase, a member of the cullin-RING ubiquitin ligases (CRLs), plays a central role in controlling oxygen metabolism.	Oxygen	272-278	ring-box 1	Homo sapiens	148-152
18420406-5	2008	The conformation-activity relationships suggest that a nonbonded intramolecular interaction between the sulfur and the carbonyl oxygen of 1 was very important in inhibiting KDR.	Oxygen	128-134	kinase insert domain receptor	Homo sapiens	173-176
18337469-0	2008	Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation.	Oxygen	34-40	egl-9 family hypoxia inducible factor 3	Homo sapiens	19-23
18337469-3	2008	Here we show that PHD3 forms subcellular aggregates in an oxygen-dependent manner.	Oxygen	58-64	egl-9 family hypoxia inducible factor 3	Homo sapiens	18-22
18337469-8	2008	The data demonstrates the cellular oxygen sensor PHD3 as a regulator of protein aggregation in response to varying oxygen availability.	Oxygen	35-41	egl-9 family hypoxia inducible factor 3	Homo sapiens	49-53
18337469-8	2008	The data demonstrates the cellular oxygen sensor PHD3 as a regulator of protein aggregation in response to varying oxygen availability.	Oxygen	115-121	egl-9 family hypoxia inducible factor 3	Homo sapiens	49-53
17975837-9	2008	Our results show that protein oxidation promotes a stabilization of the pentacoordinated species, thus favoring the protein to adopt the more reactive state and supporting the existence of a molecular mechanism whereby O2 would be released under hypoxic conditions, thereby suggesting an O(2) storage function for Ngb.	Oxygen	219-221	neuroglobin	Homo sapiens	314-317
17975837-9	2008	Our results show that protein oxidation promotes a stabilization of the pentacoordinated species, thus favoring the protein to adopt the more reactive state and supporting the existence of a molecular mechanism whereby O2 would be released under hypoxic conditions, thereby suggesting an O(2) storage function for Ngb.	Oxygen	288-292	neuroglobin	Homo sapiens	314-317
18283105-2	2008	Results demonstrate that exposure to high oxygen partial pressures increases synthesis of reactive species derived from type 2 nitric-oxide synthase and myeloperoxidase, leading to excessive S-nitrosylation of beta-actin and possibly profilin.	Oxygen	42-48	POTE ankyrin domain family member F	Homo sapiens	210-220
18323779-4	2008	In addition, we show that overexpression of Siah2 or oxygen and glucose deprivation (OGD) promotes Siah2-mediated ubiquitination and proteolysis of AKAP121.	Oxygen	53-59	A-kinase anchoring protein 1	Homo sapiens	148-155
18323779-8	2008	By regulating the stability of AKAP121-signalling complex at mitochondria, cells efficiently and rapidly adapt oxidative metabolism to fluctuations in oxygen availability.	Oxygen	151-157	A-kinase anchoring protein 1	Homo sapiens	31-38
18351757-7	2008	Similarly, the BDE for the removal of one fluorine ligand from the stable closed-shell PF3O molecule to give the unstable PF2O radical is higher than the BDE needed to remove the oxygen atom to give the stable closed-shell PF3 molecule.	Oxygen	179-185	homeobox D13	Homo sapiens	15-18
18351757-7	2008	Similarly, the BDE for the removal of one fluorine ligand from the stable closed-shell PF3O molecule to give the unstable PF2O radical is higher than the BDE needed to remove the oxygen atom to give the stable closed-shell PF3 molecule.	Oxygen	179-185	homeobox D13	Homo sapiens	154-157
18219317-1	2008	The von Hippel-Lindau tumor suppressor gene product, pVHL, functions as the substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF) for rapid proteasomal degradation under normoxic conditions and as such plays a central role in molecular oxygen sensing.	Oxygen	153-159	von Hippel-Lindau tumor suppressor	Mus musculus	53-57
18219317-1	2008	The von Hippel-Lindau tumor suppressor gene product, pVHL, functions as the substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF) for rapid proteasomal degradation under normoxic conditions and as such plays a central role in molecular oxygen sensing.	Oxygen	324-330	von Hippel-Lindau tumor suppressor	Mus musculus	53-57
18336467-0	2008	p21(Cip1) expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture.	Oxygen	45-51	KRAS proto-oncogene, GTPase	Rattus norvegicus	0-3
18336467-3	2008	In the present study, we hypothesized that 20% O2 in culture represents a sufficient stimulus to cause increased expression of two key negative regulators of the cell-cycle Cip/Kip family of cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), in MPCs.	Oxygen	47-49	calcium and integrin binding 1	Rattus norvegicus	177-180
18336467-3	2008	In the present study, we hypothesized that 20% O2 in culture represents a sufficient stimulus to cause increased expression of two key negative regulators of the cell-cycle Cip/Kip family of cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), in MPCs.	Oxygen	47-49	KRAS proto-oncogene, GTPase	Rattus norvegicus	227-230
18336467-8	2008	Furthermore, 20% O2 caused an increase in p21(Cip1) mRNA stability and p53 transcription factor activity.	Oxygen	17-19	KRAS proto-oncogene, GTPase	Rattus norvegicus	42-45
18174394-0	2008	Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats.	Oxygen	54-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	102-133
18371210-8	2008	In the IGTslow group, a significant positive correlation between the increased muscle content of HSP60 and the oxygen radical absorbing capacity values and, in the IGTfast group, between the improved VO2max value and the increased protein expression of GRP75 were found.	Oxygen	111-117	heat shock protein family D (Hsp60) member 1	Homo sapiens	97-102
18241842-1	2008	Hypoxia inducible transcription factor (HIF)-1alpha plays an important role in maintaining oxygen homeostasis.	Oxygen	91-97	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-51
18318906-5	2008	RESULTS: Wide variation in the properties of amino acids were observed at functionally important regions of cytochrome b in species with more-specialized metabolic requirements (such as adaptation to low energy diet or large body size, such as in elephant, dugong, sloth, and pangolin, and adaptation to unusual oxygen requirements, for example diving in cetaceans, flying in bats, and living at high altitudes in alpacas).	Oxygen	312-318	CYTB	Elephas maximus	108-120
18210138-1	2008	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a key regulator of cellular oxygen homeostasis.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-32
18210138-1	2008	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a key regulator of cellular oxygen homeostasis.	Oxygen	78-84	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	34-45
17950634-0	2008	The high oxygen-affinity Hemoglobin Johnstown [(beta 109(G11) Val--&gt;Leu] in a German kindred with an elevated erythrocyte hemoglobin content: potential interaction with HFE mutations.	Oxygen	9-15	serine/threonine kinase 19	Homo sapiens	48-60
18374080-7	2008	We solved the oxygen diffusion-reaction equation for 150-microm diameter islets seeded at 3000 islet equivalents per cm2, a density adequate to culture and ship an entire human or porcine islet preparation in a single gas-permeable device, predicting that about 40% of the islet volume would be anoxic at 22 degrees C and about 70% would be anoxic at 37 degrees C. Islets of larger size or islets accumulated during shipment would be even more anoxic.	Oxygen	14-20	inositol polyphosphate-5-phosphatase D	Homo sapiens	156-160
18176562-0	2008	Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.	Oxygen	28-34	egl-9 family hypoxia-inducible factor 2	Mus musculus	42-46
18176562-1	2008	HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner.	Oxygen	37-43	egl-9 family hypoxia-inducible factor 2	Mus musculus	25-31
18176562-1	2008	HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner.	Oxygen	126-132	egl-9 family hypoxia-inducible factor 2	Mus musculus	25-31
18176562-2	2008	Here, we show that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP production through activation of a Pparalpha pathway.	Oxygen	39-45	egl-9 family hypoxia-inducible factor 2	Mus musculus	27-31
18276953-6	2008	Moreover, hypoxia (2% O(2)) caused an increase in the levels of TACE mRNA and protein in villous explants and primary cytotrophoblastic cells in vitro.	Oxygen	22-27	ADAM metallopeptidase domain 17	Homo sapiens	64-68
18276953-7	2008	These results indicate that oxygen regulates the expression of TACE and that TACE may be important for placental development during human pregnancy.	Oxygen	28-34	ADAM metallopeptidase domain 17	Homo sapiens	63-67
18174477-7	2008	RESULTS: Nortriptyline inhibits oxygen/glucose deprivation-induced cell death, loss of mitochondrial membrane potential, downstream release of mitochondrial factors, and activation of caspase 3 in primary cerebrocortical neurons.	Oxygen	32-38	caspase 3	Mus musculus	184-193
17934064-7	2008	The Egfl7 expression was returned to near normal level 2 wk after discounting oxygen exposure during recovery period.	Oxygen	78-84	EGF like domain multiple 7	Homo sapiens	4-9
17576199-2	2008	Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo.	Oxygen	43-49	neuroglobin	Homo sapiens	14-17
18792902-5	2008	The produced O2 can further participate in the catalyzed reaction of GOx, forming a cyclic electron-transfer mechanism of glucose oxidation, which is favorable for the whole reaction system.	Oxygen	13-15	hydroxyacid oxidase 1	Homo sapiens	69-72
17726089-6	2008	Reverse transcription-quantitative polymerase chain reaction was used to analyze Flk1 expression in muscle and brain of animals exposed to ambient or variant hypoxic oxygen levels at multiple stages of development.	Oxygen	166-172	kinase insert domain receptor	Homo sapiens	81-85
18044948-8	2008	Along the artemisinin decomposition routes, especially B2 and B3, larger structural changes including formation of branched structures and CO2 release are related to increased exothermicity of the conversions, weakened attractive oxygen-oxygen interactions, and increased entropy of the formed species.	Oxygen	230-236	immunoglobulin kappa variable 5-2	Homo sapiens	55-64
18044948-8	2008	Along the artemisinin decomposition routes, especially B2 and B3, larger structural changes including formation of branched structures and CO2 release are related to increased exothermicity of the conversions, weakened attractive oxygen-oxygen interactions, and increased entropy of the formed species.	Oxygen	237-243	immunoglobulin kappa variable 5-2	Homo sapiens	55-64
18822852-7	2008	Our model shows that germ-line point BRCA mutations transmitted from ancestors accelerated the somatic oxygen damages and mtDNA mutations leading to phenotypic expression of premature aging and breast cancer.	Oxygen	103-109	BRCA1 DNA repair associated	Homo sapiens	37-41
18383352-0	2008	Decreasing the expression of LFA-1 and ICAM-1 as the major mechanism for the protective effect of hyperbaric oxygen on ischemia-reperfusion injury.	Oxygen	109-115	intercellular adhesion molecule 1	Homo sapiens	39-45
18332640-6	2008	On day 21, following 7 days of reparative recovery, GFAP levels in most areas of oxygen-exposed brains had returned to near control levels.	Oxygen	81-87	glial fibrillary acidic protein	Homo sapiens	52-56
17962962-0	2008	Effect of 100% oxygen on E-selectin expression, recruitment of neutrophils and enterocyte apoptosis following intestinal ischemia-reperfusion in a rat.	Oxygen	15-21	selectin E	Rattus norvegicus	25-35
17962962-11	2008	Treatment with 100% oxygen resulted in a significant attenuation in E-selectin expression in the ileum (2.7 +/- 1.1 vs. 12.1 +/- 2.7 E-selectin positive vessels/100 vessels, p &lt; 0.05), and neutrophil recruitment in the jejunum (2.5 +/- 1.4 vs. 7.7 +/- 1.9 adhered PMN"s per 100 venules, p &lt; 0.05) and ileum (1.5 +/- 0.7 vs. 5.5 +/- 1.6 adhered PMN"s per 100 venules, p &lt; 0.05) compared to IR animals, and was accompanied by decreased cell apoptosis (p &lt; 0.05).	Oxygen	20-26	selectin E	Rattus norvegicus	68-78
17962962-11	2008	Treatment with 100% oxygen resulted in a significant attenuation in E-selectin expression in the ileum (2.7 +/- 1.1 vs. 12.1 +/- 2.7 E-selectin positive vessels/100 vessels, p &lt; 0.05), and neutrophil recruitment in the jejunum (2.5 +/- 1.4 vs. 7.7 +/- 1.9 adhered PMN"s per 100 venules, p &lt; 0.05) and ileum (1.5 +/- 0.7 vs. 5.5 +/- 1.6 adhered PMN"s per 100 venules, p &lt; 0.05) compared to IR animals, and was accompanied by decreased cell apoptosis (p &lt; 0.05).	Oxygen	20-26	selectin E	Rattus norvegicus	133-143
18159247-8	2007	Moreover, studies of murine hypoxia (8% oxygen over 6 h) showed TLR2 and TLR 6 induction in mucosal organs in vivo.	Oxygen	40-46	toll-like receptor 6	Mus musculus	73-78
18251845-5	2007	Although MSC16 mitochondria have a higher AOX protein level and an increased capacity, the AOX activity measured in the dark conditions by oxygen discrimination technique is similar to that in wild-type (WT) plants.	Oxygen	139-145	ubiquinol oxidase 4, chloroplastic/chromoplastic	Cucumis sativus	91-94
17704187-4	2007	We discovered that MV of 2- to 4-day-old mice with 40% O(2) for 8 h, compared with unventilated control pups, reduced lung expression of genes that regulate lung septation and angiogenesis (VEGF-A and its receptor, VEGF-R2; PDGF-A; and tenascin-C).	Oxygen	55-59	vascular endothelial growth factor A	Mus musculus	190-196
17704187-6	2007	MV of 4- to 6-day-old mice with 40% O(2) for 24 h reduced lung protein abundance of VEGF-A, VEGF-R2, PDGF-A, and tenascin-C and resulted in lung structural abnormalities consistent with evolving CLD.	Oxygen	36-40	vascular endothelial growth factor A	Mus musculus	84-90
17704187-8	2007	Immunostaining for vimentin, which is expressed in myofibroblasts, was reduced in distal lung after 24 h of MV with 40% O(2).	Oxygen	120-124	vimentin	Mus musculus	19-27
17924615-2	2007	The structures of two representative nonpolar metabolites were identified earlier as dimers of 17beta-estradiol linked through a diaryl ether bond between the C-3 phenolic oxygen of one molecule and the C-2 or C-4 aromatic carbon of another.	Oxygen	172-178	complement C3	Homo sapiens	159-162
17715402-6	2007	DHEAS is identical to PS except that it contains a carbonyl oxygen instead of an acetyl group at C17 on the steroid D ring.	Oxygen	60-66	sulfotransferase family 2A member 1	Homo sapiens	0-5
17785451-2	2007	We have identified additional SOS2-interacting proteins that suggest a connection between SOS2 and reactive oxygen signaling.	Oxygen	108-114	Protein kinase superfamily protein	Arabidopsis thaliana	30-34
17785451-2	2007	We have identified additional SOS2-interacting proteins that suggest a connection between SOS2 and reactive oxygen signaling.	Oxygen	108-114	Protein kinase superfamily protein	Arabidopsis thaliana	90-94
17609290-2	2007	The transcriptional response to oxygen deprivation is mainly mediated by hypoxia-inducible factors (HIFs), which are targeted for proteasomal degradation by the von Hippel-Lindau tumor suppressor protein (pVHL) under normoxia.	Oxygen	32-38	von Hippel-Lindau tumor suppressor	Mus musculus	205-209
17630350-4	2007	Using these protocols with highly selective blockade of nNOS, we tested the hypothesis that brain tissue nNOS could donate NO to the arterioles at rest and during periods of reduced perivascular oxygen tension, such as during hypotension or reduced local availability of oxygen.	Oxygen	195-201	nitric oxide synthase 1	Rattus norvegicus	105-109
17630350-4	2007	Using these protocols with highly selective blockade of nNOS, we tested the hypothesis that brain tissue nNOS could donate NO to the arterioles at rest and during periods of reduced perivascular oxygen tension, such as during hypotension or reduced local availability of oxygen.	Oxygen	271-277	nitric oxide synthase 1	Rattus norvegicus	105-109
17630350-9	2007	Therefore, nNOS predominantly increased NO during decreased periarteriolar oxygen tension, such as that during hypotension, but eNOS was the dominant source of NO for flow shear mechanisms.	Oxygen	75-81	nitric oxide synthase 1	Rattus norvegicus	11-15
18306814-10	2007	The TPR and XPS results illustrated that the transformation of the lattice oxygen to non-complete reduction oxygen in NiV2O8 catalyst might promote the oxidation-reduction reaction between different valence vanadium and promoted the oxygen vacancy formation.	Oxygen	75-81	translocated promoter region, nuclear basket protein	Homo sapiens	4-7
18306814-10	2007	The TPR and XPS results illustrated that the transformation of the lattice oxygen to non-complete reduction oxygen in NiV2O8 catalyst might promote the oxidation-reduction reaction between different valence vanadium and promoted the oxygen vacancy formation.	Oxygen	108-114	translocated promoter region, nuclear basket protein	Homo sapiens	4-7
18306814-10	2007	The TPR and XPS results illustrated that the transformation of the lattice oxygen to non-complete reduction oxygen in NiV2O8 catalyst might promote the oxidation-reduction reaction between different valence vanadium and promoted the oxygen vacancy formation.	Oxygen	108-114	translocated promoter region, nuclear basket protein	Homo sapiens	4-7
17676732-1	2007	A series of TpxCu(I) complexes (Tpx=homoscorpionate ligand) have been reacted in solution with dioxygen at room temperature.	Oxygen	95-103	thyroid peroxidase	Homo sapiens	12-15
17397983-3	2007	Its activation depends on the interaction with cytosolic regulatory proteins (p67-phox, p47-phox, p40-phox and Rac) leading to an electron transfer from NADPH to molecular oxygen and to the release of superoxide anions.	Oxygen	172-178	neutrophil cytosolic factor 1	Homo sapiens	88-96
18251923-0	2007	Oxygen-induced changes in the redox state of the cytochrome b559 in photosystem II depend on the integrity of the Mn cluster.	Oxygen	0-6	mitochondrially encoded cytochrome b	Homo sapiens	49-61
18251923-1	2007	The effect of oxygen and anaerobiosis on the redox properties of Cyt b(559) was investigated in PSII preparations from spinach with different degree of disintegration of the donor side.	Oxygen	14-20	mitochondrially encoded cytochrome b	Homo sapiens	65-70
18251923-5	2007	The oxygen-dependent conversion of the intermediate potential form of Cyt b(559) into the low-potential and high-potential forms was only observed after treatments that directly affect the Mn cluster.	Oxygen	4-10	mitochondrially encoded cytochrome b	Homo sapiens	70-75
18251923-9	2007	The possible physiological role of this oxygen-dependent behavior of the Cyt b(559) redox forms during the assembly/photoactivation cycle of PSII is discussed.	Oxygen	40-46	mitochondrially encoded cytochrome b	Homo sapiens	73-78
17555889-4	2007	Furthermore, our in vivo and in vitro studies show that Escherichia coli cells contain an enzymatic reducing system that keeps the heme iron atom of neuroglobin in the Fe(2+) form in the presence of dioxygen despite the high autoxidation rate of the molecule.	Oxygen	199-207	neuroglobin	Homo sapiens	149-160
17611046-1	2007	Escherichia coli flavohaemoglobin (Hmp) is the best-understood nitric oxide (NO) detoxifying protein and exhibits a robust dioxygenase activity, converting NO to nitrate ion with oxygen as co-substrate.	Oxygen	125-131	inner membrane mitochondrial protein	Homo sapiens	35-38
17699843-8	2007	Loss of VHL or FH is thought to result in a pseudohypoxic state so that cellular response pathways mediated by HIF are activated despite normal oxygen conditions.	Oxygen	144-150	fumarate hydratase	Homo sapiens	15-17
17559924-2	2007	At the blastocyst stage, ATP is produced by glycolysis and oxidative phosphorylation, processes that require uptake of oxygen and glucose, which is regulated by the expression of GLUT1 and G6PD.	Oxygen	119-125	glucose-6-phosphate dehydrogenase	Bos taurus	189-193
17559924-10	2007	Expression of GLUT1 and G6PD mRNAs was correlated with respiration rates, indicating that, in metabolically active blastocysts, uptake of oxygen and glucose are jointly increased.	Oxygen	138-144	glucose-6-phosphate dehydrogenase	Bos taurus	24-28
17508920-7	2007	Additionally, the authors have considered Hb-based oxygen carriers (HBOCs) administration as a unique situation during which direct CD163 uptake may be relevant as a mechanism of clearance.	Oxygen	51-57	CD163 molecule	Homo sapiens	132-137
17495223-1	2007	Although the primary function of myoglobin (Mb) has been considered to be cellular oxygen storage and supply, recent studies have suggested to classify Mb as a multifunctional allosteric enzyme.	Oxygen	83-89	myoglobin	Mus musculus	33-42
17495223-1	2007	Although the primary function of myoglobin (Mb) has been considered to be cellular oxygen storage and supply, recent studies have suggested to classify Mb as a multifunctional allosteric enzyme.	Oxygen	83-89	myoglobin	Mus musculus	44-46
17495223-3	2007	Here we report that a dynamic cycle exists in which a decrease in tissue oxygen tension drives the conversion of Mb from being an NO scavenger in normoxia to an NO producer in hypoxia.	Oxygen	73-79	myoglobin	Mus musculus	113-115
17495223-6	2007	We propose that this pathway represents a novel homeostatic mechanism by which a mismatch between oxygen supply and demand in muscle is translated into the fractional increase of deoxygenated Mb exhibiting enhanced nitrite reductase activity.	Oxygen	98-104	myoglobin	Mus musculus	192-194
17495223-7	2007	Thus, Mb may act as an oxygen sensor which through NO can adjust muscle energetics to limited oxygen supply.	Oxygen	23-29	myoglobin	Mus musculus	6-8
17495223-7	2007	Thus, Mb may act as an oxygen sensor which through NO can adjust muscle energetics to limited oxygen supply.	Oxygen	94-100	myoglobin	Mus musculus	6-8
17512623-7	2007	RESULTS: In both SiHa and FaDu(DD) cells Ca9 and LOX reached the highest level of expression at 1% oxygen.	Oxygen	99-105	lysyl oxidase	Homo sapiens	49-52
17512623-10	2007	Glut1 and LDH-A had a similar expression pattern to each other, with a maximum expression at 0.01% oxygen, in both cell lines.	Oxygen	99-105	solute carrier family 2 member 1	Homo sapiens	0-5
17137780-3	2007	The product, NADPH, initiates the irreversible the hydroxylation of p-hydroxybenzoate by HBH in the presence of oxygen to produce 3,4-dihydroxybenzoate, which results in a detectable signal due to its oxidation at the working electrode.	Oxygen	112-118	2,4-dienoyl-CoA reductase 1	Homo sapiens	13-18
17452787-4	2007	Here, two structures of FGE in complex with bromide and iodide were determined in order to further delineate the volume and stereochemical restraints of the oxygen-binding site for potential reaction intermediates.	Oxygen	157-163	sulfatase modifying factor 1	Homo sapiens	24-27
17360721-3	2007	In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chaperone, suppresses mutant huntingtin-induced reactive oxygen species formation and cell death.	Oxygen	131-137	heat shock protein 1	Mus musculus	25-46
17299835-6	2007	The orbital population near the Fermi level does not depend on the cluster size and is characterized by hybridized Ni 3d and O 2p orbitals with relative oxygen contribution of about 70%.	Oxygen	153-159	immunoglobulin kappa variable 1D-39	Homo sapiens	125-129
17009332-5	2007	The oxygen binding affinity of PEGylated bRBCs was moderately increased with increasing initial SPA-mPEG concentrations up to 4 mM when reacted with bRBCs at a hematocrit of 12%.	Oxygen	4-10	pulmonary surfactant-associated protein A	Bos taurus	96-99
17009332-6	2007	Oxygen transport simulations verified that SPA-mPEG conjugated bRBCs could still transport oxygen to pancreatic islet tissues even under extreme conditions.	Oxygen	0-6	pulmonary surfactant-associated protein A	Bos taurus	43-46
17009332-6	2007	Oxygen transport simulations verified that SPA-mPEG conjugated bRBCs could still transport oxygen to pancreatic islet tissues even under extreme conditions.	Oxygen	91-97	pulmonary surfactant-associated protein A	Bos taurus	43-46
17055654-8	2007	Consistent with increased reactive oxygen levels we find that CS-A and -B cells grown under ambient oxygen show increased DNA breakage, as compared with xeroderma pigmentosum cells.	Oxygen	35-41	chorionic somatomammotropin hormone 1	Homo sapiens	62-73
17055654-8	2007	Consistent with increased reactive oxygen levels we find that CS-A and -B cells grown under ambient oxygen show increased DNA breakage, as compared with xeroderma pigmentosum cells.	Oxygen	100-106	chorionic somatomammotropin hormone 1	Homo sapiens	62-73
17383361-12	2007	Alveolar-arterial O2 gradient decreased with C1-inh dose (p = 0.009).	Oxygen	18-20	serpin family G member 1	Homo sapiens	45-51
17276676-1	2007	A new P1" group for TACE inhibitors was identified by eliminating the oxygen atom in the linker of the original 4-(2-methylquinolin-4-ylmethoxy)phenyl P1" group.	Oxygen	70-76	ADAM metallopeptidase domain 17	Homo sapiens	20-24
17400799-4	2007	Oxygen consumption was significantly and equally increased (50-70%) by T3 and GC-1.	Oxygen	0-6	solute carrier family 25 member 22	Rattus norvegicus	78-82
17382777-3	2007	We hypothesized that developing bladders are hypoxic in vivo and oxygen tensions modulate explanted bladder growth by altering vascular endothelial growth factor-A expression.	Oxygen	65-71	vascular endothelial growth factor A	Mus musculus	127-163
17382777-12	2007	In vitro, when oxygen tensions are manipulated, vascular endothelial growth factor-A protein positively correlates with the growth of whole explants as well as endothelium.	Oxygen	15-21	vascular endothelial growth factor A	Mus musculus	48-84
17376234-6	2007	In contrast, heterozygous mutations in SDHB, SDHC, and SDHD, the other SDH subunit genes, cause hereditary paraganglioma (PGL) tumors, which show constitutive activation of pathways induced by oxygen deprivation (hypoxia).	Oxygen	193-199	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	39-43
17376234-6	2007	In contrast, heterozygous mutations in SDHB, SDHC, and SDHD, the other SDH subunit genes, cause hereditary paraganglioma (PGL) tumors, which show constitutive activation of pathways induced by oxygen deprivation (hypoxia).	Oxygen	193-199	succinate dehydrogenase complex subunit C	Homo sapiens	45-49
17376234-6	2007	In contrast, heterozygous mutations in SDHB, SDHC, and SDHD, the other SDH subunit genes, cause hereditary paraganglioma (PGL) tumors, which show constitutive activation of pathways induced by oxygen deprivation (hypoxia).	Oxygen	193-199	succinate dehydrogenase complex subunit D	Homo sapiens	55-59
17254548-1	2007	Blue fluorescent protein from the calcium-binding photoprotein aequorin (BFP-aq) is a dissociable complex of Ca(2+)-bound apoaequorin and coelenteramide, and is identified as a luciferase that catalyzes the oxidation of coelenterazine by molecular oxygen to emit light.	Oxygen	248-254	ring finger protein 112	Homo sapiens	73-76
17023154-2	2007	The detection schemes involve the enzymatic reactions of the uricase leading to the depletion of dissolved oxygen level upon exposure to uric acid solution.	Oxygen	107-113	urate oxidase (pseudogene)	Homo sapiens	61-68
20483281-5	2007	The intrinsic oxygen affinity of the variant Hb (logP(50)=0.79 at pH 7.0) was found to be intermediate between that of the sheep Hb B (logP(50)=0.92) and that of Cypriot mouflon (O. a. ophion) Hb (logP(50)=0.53), the latter having only the Lys--&gt;Arg change at beta144, whereas nearly no differences were observed in the presence of the Cl(-) physiological effector.	Oxygen	14-20	hemoglobin subunit beta	Ovis aries	129-133
17120015-0	2007	PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue.	Oxygen	38-44	protein kinase C, alpha	Rattus norvegicus	0-9
17031858-4	2007	Our studies show that osteoblasts respond to hypoxia (2% oxygen) by enhancing expression of genes associated with adipocyte/lipogenesis phenotype (C/EBPbeta, PPARgamma2, and aP2) and by suppressing expression of genes associated with osteoblast differentiation (alkaline phosphatase, AP).	Oxygen	57-63	transcription factor AP-2 alpha	Homo sapiens	174-177
17969555-15	2007	Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-.	Oxygen	223-225	mitochondrially encoded cytochrome b	Homo sapiens	23-35
17203215-3	2007	Loss of the functional VHL gene causes constitutive stabilization of HIF-alpha that primarily up-regulates hypoxia-inducible genes even at normal oxygen concentration, which in turn contribute to VHL tumor progression.	Oxygen	146-152	von Hippel-Lindau tumor suppressor	Mus musculus	23-26
17203215-9	2007	Following VHL inactivation, one pathway causes oxygen-independent overexpression of classic hypoxia-inducible genes and the other one described here suppresses expression of the genes important for liver glucose metabolism.	Oxygen	47-53	von Hippel-Lindau tumor suppressor	Mus musculus	10-13
17251494-11	2007	AG3340 (MMP-2- and -9-selective inhibitor) and DPC-A37668 (MMP-2-selective inhibitor) resulted in 65% and 52% inhibition, respectively, when administered by intravitreal injection immediately after variable-oxygen exposure.	Oxygen	207-213	matrix metallopeptidase 2	Mus musculus	59-64
17251494-15	2007	There was a 75% (P &lt; 0.001) and 44% (P &lt; 0.01) reduction in preretinal neovascularization in oxygen-exposed MMP-2(-/-) and -9(-/-) mice at postnatal day 19, respectively, compared with wild-type control mice.	Oxygen	99-105	matrix metallopeptidase 2	Mus musculus	114-119
17251494-16	2007	CONCLUSIONS: The results of this study suggest that MMP-2 plays a predominant role in retinal angiogenesis in both the mouse and rat models of oxygen-induced retinopathy.	Oxygen	143-149	matrix metallopeptidase 2	Mus musculus	52-57
16977326-9	2007	The present data thus demonstrate oxygen-dependent differentiation in human keratinocytes, to which altered utilization of AP1 transcriptional response elements may contribute.	Oxygen	34-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-126
17313163-6	2007	Furthermore, our data indicate that AtWRKY70 functions downstream of defense-associated reactive oxygen intermediates and SA.	Oxygen	97-103	WRKY DNA-binding protein 70	Arabidopsis thaliana	36-44
17982276-3	2007	We report that glycolysis and oxidative phosphorylation characterized by glucose and oxygen consumption as well as lactate production were increased during receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis from RAW264.7 and bone marrow-derived macrophage cells.	Oxygen	85-91	TNF superfamily member 11	Homo sapiens	156-206
17982276-3	2007	We report that glycolysis and oxidative phosphorylation characterized by glucose and oxygen consumption as well as lactate production were increased during receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis from RAW264.7 and bone marrow-derived macrophage cells.	Oxygen	85-91	TNF superfamily member 11	Homo sapiens	208-213
17022961-2	2007	Evidence from in vitro and structural analyses supports a critical role for Cited2 in down-regulating HIF-1-mediated transcription by competing for binding with oxygen-sensitive HIF-1alpha to transcriptional co-activators CBP/p300.	Oxygen	161-167	CREB binding protein	Mus musculus	222-230
17786635-0	2007	About oxygen, cytochrome p450 and titanium: learning from Ron Estabrook.	Oxygen	6-12	macrophage stimulating 1 receptor	Homo sapiens	58-61
17598161-4	2007	In addition, this study tested the hypothesis that in vivo exposure to different oxygen (O(2)) concentrations causes a differential activation of G proteins in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus.	Oxygen	81-87	carbonic anhydrase 3	Rattus norvegicus	169-172
17598161-4	2007	In addition, this study tested the hypothesis that in vivo exposure to different oxygen (O(2)) concentrations causes a differential activation of G proteins in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus.	Oxygen	89-93	carbonic anhydrase 3	Rattus norvegicus	169-172
17483601-3	2007	O2- produced by SMA and eNOS expression were evaluated by chemiluminescence and Western blot, respectively.	Oxygen	0-2	nitric oxide synthase 3	Rattus norvegicus	24-28
16532342-9	2006	RESULTS: Exposure of SPCA1 and A549 cells to 0.5% O2 significantly increased resistance to cisplatin and doxorubicin, in contrast to cells incubated in normoxia.	Oxygen	50-52	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	21-26
17116243-8	2006	In these timescales, up to five oxygen atoms were incorporated into WT and V30M TTR proteins.	Oxygen	32-38	transthyretin	Homo sapiens	80-83
17019721-6	2006	Based on these results, design strategies for new DbetaM and PHM biomimetic ligands are proposed: new ligands should be made less electron rich so as to favor end-on dioxygen coordination in the 1:1 Cu-O(2) adducts.	Oxygen	166-174	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	61-64
17019721-7	2006	Comparison of the relative reactivities of the various copper-oxygen complexes as hydroxylating agents provides support for a Cu(II)-superoxide species as the intermediate responsible for substrate hydroxylation in DbetaM and PHM, and suggests that a Cu(III)-oxo intermediate would be competent in this process as well.	Oxygen	62-68	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	226-229
16899760-2	2006	Because Cygb shares several structural features with Mb, we hypothesized that Cygb functions in the modulation of oxygen and nitric oxide metabolism or in scavenging free radicals within a cell.	Oxygen	114-120	myoglobin	Mus musculus	53-55
17100569-7	2006	ADM plays an important role in environments subjected to low oxygen tension, which is a typical feature of solid tumors.	Oxygen	61-67	adrenomedullin	Homo sapiens	0-3
17065527-3	2006	This study was conducted to investigate the effect of TNF-Rp55 and TNF-Rp75 on retinal development in oxygen-induced retinopathy.	Oxygen	102-108	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	54-62
17132228-5	2006	Here, we demonstrate that oxygen-dependent recognition of HIFalpha by VHL triggers Rbx1-dependent neddylation of Cul2, which preferentially engages the E2 ubiquitin-conjugating enzyme UbcH5a.	Oxygen	26-32	ring-box 1	Homo sapiens	83-87
17004712-7	2006	The hypotheses are as follows: (1) it is the carboxamide oxygen of the C-3 substituent of 1 that interacts directly with K3.28(192) and (2) the interaction with K3.28(192) is crucial for the production of inverse agonism for biarylpyrazoles such as 1.	Oxygen	57-63	complement C3	Homo sapiens	71-74
17004712-14	2006	Taken together, these results support the hypothesis that it is the carboxamide oxygen of the C-3 substituent of 1 that engages in a hydrogen bond with K3.28(192) in WT CB1.	Oxygen	80-86	complement C3	Homo sapiens	94-97
16828555-5	2006	Based on the molecular interactions observed from 3D structure of 15-PGDH, we further propose that Gln-148 in 15-PGDH is important in properly positioning the 15-hydroxyl group of PGE2 by hydrogen bonding with the side-chain oxygen atom of Gln-148.	Oxygen	225-231	carbonyl reductase 1	Homo sapiens	66-73
16828555-5	2006	Based on the molecular interactions observed from 3D structure of 15-PGDH, we further propose that Gln-148 in 15-PGDH is important in properly positioning the 15-hydroxyl group of PGE2 by hydrogen bonding with the side-chain oxygen atom of Gln-148.	Oxygen	225-231	carbonyl reductase 1	Homo sapiens	110-117
16828555-9	2006	This indicates that the side-chain oxygen or nitrogen atom at position 148 of 15-PGDH plays an important role in anchoring C-15 hydroxyl group of PGE2 through hydrogen bonding for catalytic reaction.	Oxygen	35-41	carbonyl reductase 1	Homo sapiens	78-85
16520989-8	2006	In addition, in 20% O2, but not in 2% O2, 4-HPR obviously downregulated the protein expression of procaspase-3, ERK1/2 and XIAP, and increased the cleavage of PARP.	Oxygen	20-22	X-linked inhibitor of apoptosis	Homo sapiens	123-127
17002676-9	2006	As such, the three prolyl hydroxylases (prolyl hydroxylase domain-containing protein (PHD) 1, PHD2 and PHD3) and the asparagyl hydroxylase (factor inhibiting HIF (FIH)-1) act as cellular oxygen sensors.	Oxygen	187-193	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	117-169
16930618-8	2006	Whereas the side-chain of A20 or R20 would be expected to clash with the preceding carbonyl oxygen (thus accounting for its frustrated energy landscape), the side-chain of D-Ala20 projects into solvent without perturbation of the Schellman motif.	Oxygen	92-98	immunoglobulin kappa variable 1-27	Homo sapiens	26-29
16614351-7	2006	We conclude that the airways of Cftr-/- mice exhibit heretofore unappreciated structural alterations affecting cellular and neural components of the PNEC system and airway smooth muscle and its innervation resulting in blunted O2 sensing and reduced airway tonus.	Oxygen	227-229	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
16987037-7	2006	Rats treated with alpha-NO-hRBC exhibited greater recovery of metabolic acidosis and bile excretion than those treated with hRBC or CO-hRBC, displaying the best outcome of local oxygen utilization in hepatic lobules.	Oxygen	178-184	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	27-31
16616784-8	2006	For example, there is some evidence suggesting that NADPH-oxidase-derived O2- may play a role in endothelial dysfunction of cerebral arteries and a subsequent rise in cerebral vascular tone, associated with hypertension.	Oxygen	74-77	2,4-dienoyl-CoA reductase 1	Homo sapiens	52-57
16903785-2	2006	C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not.	Oxygen	19-25	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	162-167
16903785-2	2006	C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not.	Oxygen	19-25	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	169-174
16903785-2	2006	C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not.	Oxygen	19-25	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	202-207
16903785-2	2006	C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not.	Oxygen	19-25	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	202-207
16903785-2	2006	C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not.	Oxygen	233-239	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	162-167
16903785-3	2006	We show here that hyperoxia avoidance integrates food with npr-1 activity through neuromodulation of a distributed oxygen-sensing network.	Oxygen	115-121	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	59-64
16903785-6	2006	In npr-1(lf) animals, food regulation is masked by increased activity of the oxygen-sensing neurons.	Oxygen	77-83	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	3-8
16509823-2	2006	Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF.	Oxygen	6-12	egl-9 family hypoxia inducible factor 3	Homo sapiens	96-100
16691615-7	2006	The TSP1 transgenic mice also exhibited increased levels of vessel obliteration and a limited preretinal neovascularization during oxygen-induced ischemic retinopathy (OIR).	Oxygen	131-137	thrombospondin 1	Mus musculus	4-8
16791643-1	2006	Dioxygen binding at copper enzymatic sites is a fundamental aspect of the catalytic activity observed in many biological systems such as the monooxygenases, especially peptidylglycine alpha-hydroxylating monooxygenase (PHM), in which two mononuclear Cu(I) sites are involved.	Oxygen	0-8	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	168-217
16791643-1	2006	Dioxygen binding at copper enzymatic sites is a fundamental aspect of the catalytic activity observed in many biological systems such as the monooxygenases, especially peptidylglycine alpha-hydroxylating monooxygenase (PHM), in which two mononuclear Cu(I) sites are involved.	Oxygen	0-8	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	219-222
16791643-11	2006	All these allow insight into the coordination mode of O2 and into the charge transfer from Cu(I) in site Cu(M) of PHM.	Oxygen	54-56	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	114-117
16788040-8	2006	This resulted in an over perfusion of the muscles and incomplete use of myoglobin-bound oxygen.	Oxygen	88-94	myoglobin	Leptonychotes weddellii	72-81
16939115-5	2006	Cardiac surgery with or without CPB is associated with increased tissue oxygen demands, particularly by the splanchnic bed.	Oxygen	72-78	carboxypeptidase B1	Homo sapiens	32-35
16939115-6	2006	The disparity in general and regional oxygen supply and demand results in the development of mucosal hypoxia and this cannot be attributed to CPB alone.	Oxygen	38-44	carboxypeptidase B1	Homo sapiens	142-145
16785028-12	2006	When grown under high O(2) conditions, cells reset their normoxic set point upward by down-regulating the expression of PHD1-3.	Oxygen	22-26	egl-9 family hypoxia-inducible factor 2	Mus musculus	120-124
16785028-13	2006	When grown under low O(2) conditions, cells reset their normoxic set point downward by inducing the expression of PHD1-3.	Oxygen	21-25	egl-9 family hypoxia-inducible factor 2	Mus musculus	114-118
16785028-16	2006	Exposure of mice to a hyperoxic 50% O(2) ambience repressed the expression of PHD1-3, indicating that O(2)-sensitive regulation of PHD expression is effective in the brain in vivo.	Oxygen	36-40	egl-9 family hypoxia-inducible factor 2	Mus musculus	78-82
16785028-16	2006	Exposure of mice to a hyperoxic 50% O(2) ambience repressed the expression of PHD1-3, indicating that O(2)-sensitive regulation of PHD expression is effective in the brain in vivo.	Oxygen	102-106	egl-9 family hypoxia-inducible factor 2	Mus musculus	78-82
16565084-2	2006	These oxygen-sensitive modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family (PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of involvement of these and other enzymes of the same family in directing the global changes in gene expression that are induced by hypoxia.	Oxygen	6-12	egl-9 family hypoxia inducible factor 3	Homo sapiens	123-127
16565084-2	2006	These oxygen-sensitive modifications are catalyzed by members of the 2-oxoglutarate (2-OG) dioxygenase family (PHD1, PHD2, PHD3, and FIH-1), raising an important question regarding the extent of involvement of these and other enzymes of the same family in directing the global changes in gene expression that are induced by hypoxia.	Oxygen	6-12	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	133-138
16709914-11	2006	Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism.	Oxygen	89-95	hemoglobin alpha embryonic-3	Danio rerio	0-6
16641134-2	2006	Its catalytic component, responsible for the NADPH-driven reduction of oxygen to O2*-, is flavocytochrome b559, located in the membrane and consisting of gp91phox and p22phox subunits.	Oxygen	71-77	cytochrome b-245 beta chain	Homo sapiens	154-162
16686693-5	2006	Administration of the cannabinoid receptor agonist WIN55,212-2 potently inhibited extracellular oxygen and pH changes, an effect that was reversed and prevented by pre-treatment with the CB1 receptor antagonists SR141716A and AM251.	Oxygen	96-102	cannabinoid receptor 1	Rattus norvegicus	187-190
16413834-2	2006	Elegant studies using physiological, biochemical and spectroscopic analyses support a role for myoglobin in facilitated oxygen transport and as a reservoir for oxygen in muscle of diving and hypoxia-adapted animals.	Oxygen	120-126	myoglobin	Mus musculus	95-104
16413834-2	2006	Elegant studies using physiological, biochemical and spectroscopic analyses support a role for myoglobin in facilitated oxygen transport and as a reservoir for oxygen in muscle of diving and hypoxia-adapted animals.	Oxygen	160-166	myoglobin	Mus musculus	95-104
16522125-1	2006	The activation of dioxygen by dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM) is postulated to occur at a copper site ligated by two histidine imidazoles and a methionine thioether, which is unusual because such thioether ligation is not present in other O2-activating copper proteins.	Oxygen	18-26	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	71-120
16522125-1	2006	The activation of dioxygen by dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM) is postulated to occur at a copper site ligated by two histidine imidazoles and a methionine thioether, which is unusual because such thioether ligation is not present in other O2-activating copper proteins.	Oxygen	18-26	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	122-125
16540390-3	2006	Exposure of bovine aortic endothelial cells to 10% O2 increased XOR mRNA and protein abundance by 50%.	Oxygen	51-53	xanthine dehydrogenase	Bos taurus	64-67
16619502-1	2006	BACKGROUND: The expression of vascular endothelial growth factor (VEGF), a key regulator of angiogenesis, is controlled by the oxygen supply.	Oxygen	127-133	vascular endothelial growth factor A	Mus musculus	30-64
16619502-1	2006	BACKGROUND: The expression of vascular endothelial growth factor (VEGF), a key regulator of angiogenesis, is controlled by the oxygen supply.	Oxygen	127-133	vascular endothelial growth factor A	Mus musculus	66-70
16801739-14	2006	On the contrary, the increase of AFA revealed a recovery of fat-metabolism (corresponding to RQ decrease) and lipid/carbohydrates oxidation improvement, only in the presence, at the same time, of O2 consumption increase.	Oxygen	196-198	AFA	Homo sapiens	33-36
16344970-0	2006	Models for dioxygen activation by the CuB site of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase.	Oxygen	11-19	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	82-131
16437160-7	2006	We hypothesize that transcription of the siderophore transporter ARN1 permits yeast to accumulate iron in the absence of oxygen and to deny iron to competing organisms.	Oxygen	121-127	siderophore transporter	Saccharomyces cerevisiae S288C	65-69
16282331-0	2006	PsbR, a missing link in the assembly of the oxygen-evolving complex of plant photosystem II.	Oxygen	44-50	photosystem II subunit R	Arabidopsis thaliana	0-4
16282331-3	2006	Using the Arabidopsis psbR mutant, we showed that the light-saturated rate of oxygen evolution is strongly reduced in the absence of PsbR, particularly in low light-grown plants.	Oxygen	78-84	photosystem II subunit R	Arabidopsis thaliana	22-26
16282331-7	2006	Our results provided evidence that PsbR is an important link in the PSII core complex for stable assembly of the oxygen-evolving complex protein PsbP, whereas the effects on the assembly of PsbQ are probably indirect.	Oxygen	113-119	photosystem II subunit R	Arabidopsis thaliana	35-39
16368756-1	2006	The formylglycine (FGly)-generating enzyme (FGE) uses molecular oxygen to oxidize a conserved cysteine residue in all eukaryotic sulfatases to the catalytically active FGly.	Oxygen	64-70	sulfatase modifying factor 1	Homo sapiens	44-47
16683692-0	2006	Neuroglobin, a new oxygen binding protein is present in the carotid body and increases after chronic intermittent hypoxia.	Oxygen	19-25	neuroglobin	Homo sapiens	0-11
17090432-1	2006	Hemoglobin based oxygen carriers (HBOC) are resuspended in "excipients" consisting of Ringer"s D,L-lactate containing antioxidants to prevent methemoglobin formation during storage.	Oxygen	17-23	hemoglobin subunit gamma 2	Homo sapiens	142-155
16417263-6	2006	Although 6a and 6b are incorporated into the hydrophobic domains of HSA to produce the albumin-heme hybrid, only HSA-6a can bind O2 in aqueous medium.	Oxygen	129-131	olfactory receptor family 4 subfamily Q member 3	Homo sapiens	113-118
16210362-2	2006	Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal muscle to stimulate thermogenesis, an effect that is more pronounced in oxidative than in glycolytic muscles and that can be inhibited by a selective CRH-R2 antagonist or blunted by a nonselective CRH receptor antagonist.	Oxygen	38-44	corticotropin releasing hormone	Mus musculus	120-123
16369002-2	2006	Accordingly, we assessed the global oxygen stress regulator OxyR of Escherichia coli as a possible virulence factor in UTI by determining the impact of oxyR inactivation on experimental urovirulence in CBA/J and C57BL (both wild-type and p47(phox-/-)) mice.	Oxygen	36-42	Y box protein 3	Mus musculus	60-64
16328220-4	2006	INTERVENTIONS: Jejunal mucosal tissue PO2 was measured employing two Clark-type surface oxygen electrodes.	Oxygen	88-94	PO2	Sus scrofa	38-41
16328781-0	2006	Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.	Oxygen	11-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
17018414-5	2006	The BOD5/TOC (5-day biological oxygen demand/total organic carbons) ratios of the ozonated Reactive Red 120 and Acid Red 299 solutions would increase and have the maximum values.	Oxygen	31-37	rhomboid 5 homolog 2	Homo sapiens	9-12
16686428-4	2006	Recent studies have demonstrated that the function of FIH-1 relative to the HIF prolyl hydroxylases (PHDs) is not redundant, and indicate that FIH-1 is a direct oxygen sensor.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	54-59
16686428-4	2006	Recent studies have demonstrated that the function of FIH-1 relative to the HIF prolyl hydroxylases (PHDs) is not redundant, and indicate that FIH-1 is a direct oxygen sensor.	Oxygen	161-167	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	143-148
16686428-6	2006	The relative oxygen affinities and hypoxic activities of FIH-1 and the PHDs will be discussed.	Oxygen	13-19	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	57-62
16154530-1	2005	O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements.	Oxygen	0-2	heme oxygenase 1	Rattus norvegicus	109-125
16311911-6	2005	Co-immunoprecipitation of PKCdelta and RACK-1 demonstrated O2 *- dependent increase in PKCdelta-RACK-1 interaction in the microsomes.	Oxygen	59-61	receptor for activated C kinase 1	Bos taurus	39-45
16311911-6	2005	Co-immunoprecipitation of PKCdelta and RACK-1 demonstrated O2 *- dependent increase in PKCdelta-RACK-1 interaction in the microsomes.	Oxygen	59-61	receptor for activated C kinase 1	Bos taurus	96-102
16311911-8	2005	Treatment of the smooth muscle tissue with the O2 *- generating system causes phosphorylation of G(i)alpha in the microsomes and pretreatment with TIMP-2 and rottlerin prevented the phosphorylation.	Oxygen	47-49	TIMP metallopeptidase inhibitor 2	Bos taurus	147-153
16311911-10	2005	We suggest the existence of a pertussis toxin sensitive G protein mediated mechanism for inhibition of Na+ dependent Ca2+ uptake in microsomes of bovine pulmonary artery smooth muscle under O2 *- triggered condition, which is regulated by PKCdelta dependent phosphorylation and sensitive to TIMP-2 for its inhibition.	Oxygen	190-192	TIMP metallopeptidase inhibitor 2	Bos taurus	291-297
16174769-2	2005	In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have activities comparable to those of their human counterparts.	Oxygen	91-97	alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase	Mus musculus	126-130
16275926-5	2005	In addition, we present biochemical data that show that MICAL(fd) is a flavoenzyme that in the presence of NADPH reduces molecular oxygen to H(2)O(2) (K(m,NAPDH) = 222 microM; k(cat) = 77 sec(-1)), a molecule with known signaling properties.	Oxygen	131-137	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	56-65
15994856-6	2005	Similar to what was observed in RMECs, total PKC activity was also stimulated in cerebral microvessels isolated from rats exposed to hypoxia (6% O2-94% N2; 1 h) and posthypoxic reoxygenation (room air; 10 min).	Oxygen	145-147	protein kinase C, gamma	Rattus norvegicus	45-48
15994856-7	2005	In contrast, hypoxia (6% O2-94% N2; 1 h) and posthypoxic reoxygenation (room air; 10 min) significantly increased the expression levels of only PKC-gamma and PKC-theta in the in vivo hypoxia model.	Oxygen	25-27	protein kinase C, gamma	Rattus norvegicus	144-153
16276418-2	2005	nNOS protein was increased in aorta, mesenteric arterioles, pulmonary arteries, brain, and diaphragm from rats exposed to 8% O2 for 48 hours and in human aortic SMCs after hypoxic incubation (1% O2).	Oxygen	125-127	nitric oxide synthase 1	Rattus norvegicus	0-4
16276418-2	2005	nNOS protein was increased in aorta, mesenteric arterioles, pulmonary arteries, brain, and diaphragm from rats exposed to 8% O2 for 48 hours and in human aortic SMCs after hypoxic incubation (1% O2).	Oxygen	195-197	nitric oxide synthase 1	Rattus norvegicus	0-4
16151639-1	2005	The function of alpha globin in the context of oxygen transport in erythroid cells is well described.	Oxygen	47-53	hemoglobin alpha, adult chain 1	Mus musculus	16-28
16205612-1	2005	AIM: The aim of this study was to evaluate the inspiration fraction of oxygen (FiO2) trend as an indicator of timing to suspend nasal continuous positive airway pressure (N-CPAP) and shift the babies to mechanical ventilation, in order to reduce the incidence of pneumothorax, comparing a similar population admitted in our division during the previous year.	Oxygen	71-77	centromere protein J	Homo sapiens	173-177
16166624-2	2005	GCMa regulates expression of syncytin gene, which encodes for a placenta-specific membrane protein that mediates trophoblastic fusion and the formation of syncytiotrophoblast layer required for efficient fetal-maternal exchange of nutrients and oxygen.	Oxygen	245-251	glial cells missing transcription factor 1	Homo sapiens	0-4
16202057-5	2005	As more than one-third of the transfused RBCC units are stored for longer than 3 weeks, the research examining differences in oxygen delivery between fresh and stored RBCC is relevant for packed RBC transfusion practice.	Oxygen	126-132	tripartite motif containing 17	Homo sapiens	167-171
16255686-10	2005	These changes eventually impact on delivery of oxygen and nutrients to the RPE and outer neural retina because of reduced flow in the choriocapillaris and the increasing barriers to effective diffusion.	Oxygen	47-53	ribulose-5-phosphate-3-epimerase	Homo sapiens	75-78
15970532-5	2005	An intramolecular electron transfer rate constant of 1.0x10(5) s(-1) was obtained for the activated GOx, compared with the rate constant of 7.0x10(2) s(-1) of the natural GOx-oxygen system, making this an amenable system for biosensor applications.	Oxygen	175-181	hydroxyacid oxidase 1	Homo sapiens	100-103
15970532-5	2005	An intramolecular electron transfer rate constant of 1.0x10(5) s(-1) was obtained for the activated GOx, compared with the rate constant of 7.0x10(2) s(-1) of the natural GOx-oxygen system, making this an amenable system for biosensor applications.	Oxygen	175-181	hydroxyacid oxidase 1	Homo sapiens	171-174
16000154-0	2005	Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells.	Oxygen	82-88	CREB binding protein	Rattus norvegicus	75-78
16000154-2	2005	Here, we show that exposure of PC12 and cells to 1-10% oxygen results in hyperphosphorylation of p300/CBP.	Oxygen	55-61	CREB binding protein	Rattus norvegicus	102-105
16179526-1	2005	Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen.	Oxygen	124-130	neuroglobin	Homo sapiens	0-11
16179526-1	2005	Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen.	Oxygen	124-130	neuroglobin	Homo sapiens	13-16
16179526-2	2005	Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo.	Oxygen	43-49	neuroglobin	Homo sapiens	14-17
16014049-0	2005	Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II.	Oxygen	0-6	nitric oxide synthase 3	Canis lupus familiaris	45-66
16026872-8	2005	Hypoxia (48-72 h of 0.2% O2) decreased RNA expression of a number of HR-related genes (e.g. Rad51, Rad52, Rad54, BRCA1, BRCA2) in both normal and malignant cultures.	Oxygen	25-27	RAD51 recombinase	Homo sapiens	92-97
16026872-8	2005	Hypoxia (48-72 h of 0.2% O2) decreased RNA expression of a number of HR-related genes (e.g. Rad51, Rad52, Rad54, BRCA1, BRCA2) in both normal and malignant cultures.	Oxygen	25-27	RAD54 like	Homo sapiens	106-111
16026872-8	2005	Hypoxia (48-72 h of 0.2% O2) decreased RNA expression of a number of HR-related genes (e.g. Rad51, Rad52, Rad54, BRCA1, BRCA2) in both normal and malignant cultures.	Oxygen	25-27	BRCA1 DNA repair associated	Homo sapiens	113-118
16026872-8	2005	Hypoxia (48-72 h of 0.2% O2) decreased RNA expression of a number of HR-related genes (e.g. Rad51, Rad52, Rad54, BRCA1, BRCA2) in both normal and malignant cultures.	Oxygen	25-27	BRCA2 DNA repair associated	Homo sapiens	120-125
15913562-6	2005	Infusion of AM reduced both O2*- and eNOS expression to levels comparable to those seen in DR rats.	Oxygen	28-30	adrenomedullin	Rattus norvegicus	12-14
16095180-0	2005	Endothelin-1 concentrations in clone calves, their surrogate dams, and fetal fluids at birth: association with oxygen treatment.	Oxygen	111-117	endothelin 1	Bos taurus	0-12
16095180-6	2005	Fetal fluid ET-1 concentration greater than 1.4 ng/mL carried a 3-fold increase in odds of the calf being treated with oxygen.	Oxygen	119-125	endothelin 1	Bos taurus	12-16
16095180-7	2005	Maternal plasma ET-1 concentration was greater in the O2 group (13 pg/ mL: [8-23 pg/mL] versus 25 pg/mL [12-40 pg/mL]; median, 25-75 percentile).	Oxygen	54-56	endothelin 1	Bos taurus	16-20
16026053-1	2005	BACKGROUND: Previous studies suggest that normothermic cardiopulmonary bypass(CPB) impairs cerebral oxygen balance.	Oxygen	100-106	carboxypeptidase B1	Homo sapiens	78-81
16026053-2	2005	We studied the effect of normothermic CPB on cerebral oxygen balance evaluated by continuous measurement of oxygen saturation in the jugular vein (SjO2).	Oxygen	54-60	carboxypeptidase B1	Homo sapiens	38-41
15939441-2	2005	However, the influence of heart rate on myocardial oxygen tension (pO2) remains unclear.	Oxygen	51-57	PO2	Sus scrofa	67-70
15939441-3	2005	Since the introduction of flexible pO2 micro catheters to measure partial oxygen tension in a working muscle, it is possible to investigate the influence of heart rate on myocardial oxygen tension.	Oxygen	74-80	PO2	Sus scrofa	35-38
15939441-3	2005	Since the introduction of flexible pO2 micro catheters to measure partial oxygen tension in a working muscle, it is possible to investigate the influence of heart rate on myocardial oxygen tension.	Oxygen	182-188	PO2	Sus scrofa	35-38
15932948-3	2005	In this paper we report a number of kinetic experiments with O2 and NO that we have interpreted on the basis of the 3D structure of Ngb, now available for human and murine metNgb and murine NgbCO.	Oxygen	61-63	neuroglobin	Homo sapiens	132-135
15932948-9	2005	Based on the ligand-linked conformational changes discovered by crystallography, the pathways of the reactions with O2 and NO provide a framework that may account for the involvement of Ngb in controlling the activation of a protective signaling mechanism.	Oxygen	116-118	neuroglobin	Homo sapiens	186-189
15896344-3	2005	Treatment with low oxygen modestly increased expression of protein and mRNA levels for both the +IRE and -IRE species of DMT1.	Oxygen	19-25	RoBo-1	Rattus norvegicus	121-125
15896344-5	2005	Message levels for the 1A isoforms increased approximately 60-fold after exposure of PC12 cells to 1% oxygen for 5 h. The subcellular distribution of exon 1A isoforms of DMT1 remained consistently in the cytoplasmic milieu of the cell after hypoxic exposure, as also did the distribution of +IRE species of DMT1.	Oxygen	102-108	RoBo-1	Rattus norvegicus	170-174
15896344-5	2005	Message levels for the 1A isoforms increased approximately 60-fold after exposure of PC12 cells to 1% oxygen for 5 h. The subcellular distribution of exon 1A isoforms of DMT1 remained consistently in the cytoplasmic milieu of the cell after hypoxic exposure, as also did the distribution of +IRE species of DMT1.	Oxygen	102-108	RoBo-1	Rattus norvegicus	307-311
16049787-3	2005	A site-directed mutant of MSP, C28A, C51A, which lacks the -S-S- bridge, also binds to PS II at wild-type levels and reconstitutes oxygen evolution activity [Betts et al.	Oxygen	131-137	microseminoprotein beta	Homo sapiens	26-29
16049787-7	2005	In the case of aggregation resistance by MSP, this is likely to be an important factor in its ability to avoid unproductive self-association reactions in favor of formation of the protein-protein interactions that lead to formation of the functional oxygen evolving complex.	Oxygen	250-256	microseminoprotein beta	Homo sapiens	41-44
15890345-2	2005	The results show that exposure of isolated rat brain mitochondria to Abeta(31-35) and Abeta(25-35) peptides determines: (i) release of cytochrome c; (ii) mitochondrial swelling and (iii) a significant reduction in mitochondrial oxygen consumption.	Oxygen	228-234	amyloid beta precursor protein	Rattus norvegicus	69-74
15890345-2	2005	The results show that exposure of isolated rat brain mitochondria to Abeta(31-35) and Abeta(25-35) peptides determines: (i) release of cytochrome c; (ii) mitochondrial swelling and (iii) a significant reduction in mitochondrial oxygen consumption.	Oxygen	228-234	amyloid beta precursor protein	Rattus norvegicus	86-91
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	Oxygen	117-123	corticotropin releasing hormone	Mus musculus	13-16
16852061-3	2005	In-situ MIR-IR experiments have indicated that the TaON surface is slightly oxidized under visible-light irradiation, indicating that the oxygen photoevolution on TaON actually occurs on a thin Ta-oxide overlayer.	Oxygen	138-144	membrane associated ring-CH-type finger 8	Homo sapiens	8-11
15817884-1	2005	Myoglobin is an important intracellular O2 binding hemoprotein in heart and skeletal muscle.	Oxygen	40-42	myoglobin	Mus musculus	0-9
15817884-2	2005	Surprisingly, disruption of myoglobin in mice (myo-/-) resulted in no obvious phenotype and normal cardiac function was suggested to be mediated by structural alterations that tend to steepen the oxygen pressure gradient from capillary to mitochondria.	Oxygen	196-202	myoglobin	Mus musculus	28-37
15817884-7	2005	Because of the O2-sparing effect of glucose utilization, the observed shift in substrate metabolism benefits energy homoeostasis and therefore represents a molecular adaptation process allowing to compensate for lack of the cytosolic oxygen carrier myoglobin.	Oxygen	15-17	myoglobin	Mus musculus	249-258
16851821-2	2005	Three steps were proposed for the reaction between the semiconductor oxide and the gaseous component: (i) the formation of bielectronic oxygen vacancies (V(o)) in SnO(2); (ii) their single-ionization (V(o)(*)) with injection of electrons into the SnO(2) conduction band; (iii) the subsequent transfer of electrons from V(o)(*) to [Ru(Pd,Pt)](4+).	Oxygen	136-142	strawberry notch homolog 2	Homo sapiens	163-166
16851821-3	2005	The last process induces the formation of further oxygen vacancies which reduce the transition metal centers to lower oxidation states; the redox processes is enhanced and the electrical resistance in transition metal-doped SnO(2) is stronger modified with respect to the undoped material.	Oxygen	50-56	strawberry notch homolog 2	Homo sapiens	224-227
15796519-2	2005	We report that a biomimetic Lewis acid-promoted cyclization of 1 to 2 proceeds with endo-regioselectivity and anti-stereospecificity at each position of nucleophilic addition (C3, C7, C11, and C15 in 1) when the tandem cyclization cascade is terminated by a carbonyl oxygen nucleophile.	Oxygen	267-273	aldo-keto reductase family 1 member C4	Homo sapiens	184-187
15689487-7	2005	Culturing B16F0 melanoma cells at 1.5% O(2) resulted in increased alphavbeta3 integrin surface expression and increased adhesion to and migration toward vitronectin.	Oxygen	39-43	vitronectin	Mus musculus	153-164
15742265-14	2005	There was a relationship between oxygen free radicals derived from irradiation and up-regulation of ICAM-1 expression.	Oxygen	33-39	intercellular adhesion molecule 1	Sus scrofa	100-106
15479158-1	2005	HGO (homogentisate 1,2-dioxygenase; EC 1.13.11.5) catalyses the O2-dependent cleavage of HGA (homogentisate) to maleylacetoacetate in the catabolism of tyrosine.	Oxygen	64-66	homogentisate 1,2-dioxygenase	Homo sapiens	5-34
15557328-7	2005	Our findings clearly show that under conditions of O2*- -mediated oxidative stress, IRP1 is not essential for the maintenance of iron metabolism in mammals.	Oxygen	51-53	aconitase 1	Mus musculus	84-88
15710418-3	2005	We show here in the mouse model of oxygen-induced retinopathy that VEGF is significantly increased (P&lt;0.01) in the retina at both the mRNA and protein levels.	Oxygen	35-41	vascular endothelial growth factor A	Mus musculus	67-71
15686361-2	2005	Spectroscopic characterization of the catalytically competent iron-oxo species in iodosobenzene (PhIO)-supported model reactions and parallels between these model reactions and PhIO- and NADPH/O2-supported P450 reactions have been taken as strong evidence for this proposal.	Oxygen	193-195	2,4-dienoyl-CoA reductase 1	Homo sapiens	187-192
15686361-3	2005	To support this proposal, subtle differences observed in regio- and chemoselectivities, isotope effects, and source of oxygen, etc., between NADPH/O2- and PhIO-supported P450 reactions have been generally attributed to reasons other than the mechanistic differences between the two systems.	Oxygen	119-125	2,4-dienoyl-CoA reductase 1	Homo sapiens	141-146
15686361-3	2005	To support this proposal, subtle differences observed in regio- and chemoselectivities, isotope effects, and source of oxygen, etc., between NADPH/O2- and PhIO-supported P450 reactions have been generally attributed to reasons other than the mechanistic differences between the two systems.	Oxygen	147-149	2,4-dienoyl-CoA reductase 1	Homo sapiens	141-146
15686361-4	2005	In the present study, we have used a series of sensitive mechanistic probes, 4-chloro-N-cyclopropyl-N-alkylanilines, to compare and contrast the chemistries of the NADPH/O2- and PhIO-supported purified CYP2B1 N-dealkylation reactions.	Oxygen	170-172	2,4-dienoyl-CoA reductase 1	Homo sapiens	164-169
15686361-5	2005	Herein we present the first experimental evidence to demonstrate that the NADPH/O2- and PhIO-supported P450 N-dealkylations are mechanistically distinct and, thus, the P450/PhIO system may not be a good mechanistic model for P450/NADPH/O2-catalyzed N-dealkylations.	Oxygen	80-82	2,4-dienoyl-CoA reductase 1	Homo sapiens	74-79
15667224-1	2005	The diiron center in stearoyl-acyl carrier protein (ACP) desaturase (DS) from castor plant Ricinus communis catalyzes the dioxygen- and NADPH-dependent introduction of a cis double bond between C9 and C10 of stearoyl-ACP.	Oxygen	122-130	stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic	Ricinus communis	21-67
15659679-12	2005	In-frame deletions were introduced into genes encoding the known and putative global transcriptional regulators ArcA, CRP, and EtrA (FNR), which respond to changes in oxygen tension in S. oneidensis MR-1.	Oxygen	167-173	cAMP-activated global transcriptional regulator CRP	Shewanella oneidensis MR-1	118-121
15490150-1	2005	OBJECTIVE: The purpose of this prospective study was to measure in vivo blood oxygen saturation (%O2) by MRI in children with congenital heart disease (CHD) using population-based values for T2O (T2 signal decay of fully oxygenated blood) and K (a parameter representing the deoxyhemoglobin effect) and compare the %O2 with direct cardiac catheterization measurements.	Oxygen	78-84	immunoglobulin kappa variable 1D-39	Homo sapiens	97-100
15490150-9	2005	CONCLUSION: The study indicates that the noninvasive measurement of %O2 by MRI can accurately measure oxygen saturation in children with complex CHD.	Oxygen	102-108	immunoglobulin kappa variable 1D-39	Homo sapiens	68-71
15649080-7	2005	Even though the atmosphere over the drop was O2 at 1 atm pressure, the wired BOD disk scavenged the O2 so effectively that the glucose-reduced FADH2 of GOx was not oxidized by O2, the natural cosubstrate of the enzyme.	Oxygen	100-102	hydroxyacid oxidase 1	Homo sapiens	152-155
15607330-5	2005	Rb1 also significantly reduced levels of lactate dehydrogenase (LDH) release from primary hippocampal neurons which were maintained at low oxygen concentration, indicating increased neuronal survival by Rb1.	Oxygen	139-145	RB transcriptional corepressor 1	Rattus norvegicus	0-3
15624982-1	2005	Treatment of highly potent and densely functionalized bryostatin analogue 1 with dimethyldioxirane afforded the C-9 hydroxylated hemiketal 2 via oxyfunctionalization of the C9-CH bond, one of 12 CH bonds geminal to an oxygen substituent in 1.	Oxygen	218-224	complement C9	Homo sapiens	112-115
15377493-8	2005	Low oxygen increased expression of VEGF, but not that of the VEGF receptor (Flk-1).	Oxygen	4-10	vascular endothelial growth factor A	Mus musculus	35-39
16210840-4	2005	Lung histopathology after 2-4 weeks of positive-pressure ventilation with oxygen-rich gas results in failed formation of alveoli and lung capillaries, excess disordered elastin accumulation, smooth muscle overgrowth in small pulmonary arteries and airways, chronic inflammation and interstitial edema.	Oxygen	74-80	elastin	Ovis aries	169-176
15486956-8	2005	Our study links the constitutive glycolytic activity and ANT2 expression levels of transformed cells with the loss of cell-cycle control after oxygen deprivation.	Oxygen	143-149	solute carrier family 25 member 5	Homo sapiens	57-61
15515055-0	2005	Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst.	Oxygen	0-6	vascular endothelial growth factor A	Mus musculus	51-55
15515055-8	2005	Expression of GLUT-1, GLUT-3, and vascular endothelial growth (VEGF) was increased by 2- to 4-fold in embryos cultured under 2% oxygen, when compared to embryos cultured under 20 or 7% oxygen, and when compared to embryos developed in vivo (all P &lt; 0.001).	Oxygen	128-134	vascular endothelial growth factor A	Mus musculus	63-67
15515055-8	2005	Expression of GLUT-1, GLUT-3, and vascular endothelial growth (VEGF) was increased by 2- to 4-fold in embryos cultured under 2% oxygen, when compared to embryos cultured under 20 or 7% oxygen, and when compared to embryos developed in vivo (all P &lt; 0.001).	Oxygen	185-191	vascular endothelial growth factor A	Mus musculus	63-67
16159102-10	2005	Treatment with BDNF was protective against radiation and oxygen deprivation only.	Oxygen	57-63	brain-derived neurotrophic factor	Rattus norvegicus	15-19
15504084-5	2005	Both the consumption of UCA and G6PD are faster at low oxygen concentrations.	Oxygen	55-61	glucose-6-phosphate dehydrogenase	Homo sapiens	32-36
15796813-0	2005	[Effects of high concentration of oxygen on heme oxygenase-1 and carbon monoxide in the lung of neonatal rats].	Oxygen	34-40	heme oxygenase 1	Rattus norvegicus	44-60
15584734-6	2004	The resulting anthracene and olefin radical cations undergo the radical coupling reactions with O2*- to produce the epidioxyanthracene (An-O2) and dioxetane, respectively.	Oxygen	96-98	anoctamin 2	Homo sapiens	136-141
15284058-7	2004	These data demonstrate that HO-1 gene transfer in hyperglycemic rats brings about a reduction in O2- production and a decrease in endothelial cell sloughing.	Oxygen	97-99	heme oxygenase 1	Rattus norvegicus	28-32
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	59-65	solute carrier family 2 member 1	Homo sapiens	354-360
15315937-3	2004	One of the key mediators of the cell"s response to lowered oxygen environments is hypoxia-inducible-factor-1 (HIF-1), a basic helix-loop-helix transcription factor, which enables cells to adapt to hypoxia by regulating the expression of genes involved in increasing oxygen availability (VEGF, erythropoietin) and enhancing glucose uptake and metabolism (Glut-1, PGK).	Oxygen	266-272	solute carrier family 2 member 1	Homo sapiens	354-360
15691200-3	2004	The catalytic process was examined during batch reactions controlling Chemical Oxygen Demand (COD) and Adsorbable Organic Halogen (AOX) parameters, resulting AOX abatement to achieve better effect.	Oxygen	79-85	acyl-CoA oxidase 1	Homo sapiens	158-161
15642322-16	2004	It appears that full activity of TrxR1, an enzyme required for the production of deoxyribonucletides for DNA synthesis, is essential for the normal growth of O2-challenged LECs.	Oxygen	158-160	thioredoxin reductase 1	Homo sapiens	33-38
15596104-10	2004	We suggest that ADH activity may play a role in chilling tolerance that is not related to maintenance of glycolysis and ATP production as has been observed during oxygen depravation.	Oxygen	163-169	uncharacterized protein LOC100285036	Zea mays	16-19
15527769-1	2004	Blue fluorescent protein from the calcium-sensitive photoprotein aequorin (BFP-aq) was prepared and determined to be a heat resistant enzyme, catalyzing the luminescent oxidation of coelenterazine (luciferin) with molecular oxygen as a general luciferase.	Oxygen	224-230	ring finger protein 112	Homo sapiens	75-78
15672783-1	2004	Recombinant human serum albumin (rHSA) incorporating synthetic heme with a covalently linked proximal base (albumin-heme [rHSA-hemel) is an artificial O2 carrier that can transport O2 like hemoglobin does in the blood stream.	Oxygen	151-153	albumin	Rattus norvegicus	18-31
15672783-1	2004	Recombinant human serum albumin (rHSA) incorporating synthetic heme with a covalently linked proximal base (albumin-heme [rHSA-hemel) is an artificial O2 carrier that can transport O2 like hemoglobin does in the blood stream.	Oxygen	181-183	albumin	Rattus norvegicus	18-31
15516766-0	2004	Preparation of enantiopure norbornane ligands bearing both (2S,3S)-bis(phosphinomethyl) and 7-syn-oxygen functional groups and an application to rhodium-catalyzed asymmetric hydrogenation.	Oxygen	98-104	synemin	Homo sapiens	94-97
15452028-5	2004	Hypoxia (4.6% O2, 3 hours) decreased A2A mRNA from 1.56+/-0.3% to 0.16+/-0.01% of beta-actin expression but increased A2B mRNA from 0.08+/-0.01% to 0.27+/-0.05%.	Oxygen	14-16	POTE ankyrin domain family member F	Homo sapiens	82-92
15804831-4	2004	This distribution is indicative of a function of neuroglobin in metabolically most active, oxygen-consuming cell types, but does not yet allow to safely distinguish between different cellular roles, such as oxygen homeostasis, scavenging of reactive oxygen species or sustaining energy metabolism.	Oxygen	91-97	neuroglobin	Homo sapiens	49-60
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	neuroglobin	Homo sapiens	50-61
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	121-127	neuroglobin	Homo sapiens	63-66
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	neuroglobin	Homo sapiens	50-61
15804832-1	2004	In analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery.	Oxygen	129-131	neuroglobin	Homo sapiens	63-66
15804833-6	2004	We present the current knowledge on the functional properties of neuroglobin and cytoglobin, and describe a mathematical model to evaluate the role of mammalian retinal neuroglobin in supplying O2 supply to the mitochondria.	Oxygen	194-196	neuroglobin	Homo sapiens	169-180
15292276-6	2004	Recent advances include the discovery of two novel families of mammalian APP (peptidoglycan recognition proteins and neutrophil gelatinase-associated lipocalin), that the oxygen-dependent and oxygen-independent systems are inextricably linked, that APP can be deployed in the context of novel subcellular organelles, and APP and the Toll-like receptor system interact.	Oxygen	171-177	lipocalin 2	Homo sapiens	117-159
15292276-6	2004	Recent advances include the discovery of two novel families of mammalian APP (peptidoglycan recognition proteins and neutrophil gelatinase-associated lipocalin), that the oxygen-dependent and oxygen-independent systems are inextricably linked, that APP can be deployed in the context of novel subcellular organelles, and APP and the Toll-like receptor system interact.	Oxygen	192-198	lipocalin 2	Homo sapiens	117-159
15474027-3	2004	We show that all three are capable of high rates of catalysis, in the order PHD2=PHD3&gt;PHD1, using substrate peptides derived from the C-terminal degradation domain of HIF-alpha subunits, and that each demonstrates similar and remarkable sensitivity to oxygen, commensurate with a common role in signaling hypoxia.	Oxygen	255-261	egl-9 family hypoxia inducible factor 3	Homo sapiens	81-85
15453999-4	2004	Therefore, the aim of the present study was to evaluate the relationship between the individual arterial oxygen saturation (Sa(O2)) after a 20- to 30-min exposure to poikilocapnic hypoxia and the AMS susceptibility based on repeated observations.	Oxygen	105-111	immunoglobulin kappa variable 1D-39	Homo sapiens	124-129
15525582-8	2004	BeWo and Rcho-1 cells cultured under 5% O2 or with CoCl2 showed increased expression of HIF-1alpha protein compared with those cultured under 20% O2.	Oxygen	40-42	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98
15525582-10	2004	Exogeneous HIF-1alpha markedly increased the GLUT1 promoter activity from constructs containing the HRE site, while the GLUT1 promoter constructs lacking the HRE site were not activated by exogenous HIF-1alpha These data demonstrate that GLUT1 is up-regulated under 5% O2 or in the presence of CoCl2 in the placental cell lines through HIF-1alpha interaction with a consensus HRE site of the GLUT1 promoter.	Oxygen	269-271	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	11-21
15380940-4	2004	The effect of oxygen on the expression of membrane-bound (mb) and soluble (s) HLA-G was investigated in primary cultures of extravillous CTs.	Oxygen	14-20	ATP binding cassette subfamily A member 1	Homo sapiens	42-56
15380940-4	2004	The effect of oxygen on the expression of membrane-bound (mb) and soluble (s) HLA-G was investigated in primary cultures of extravillous CTs.	Oxygen	14-20	major histocompatibility complex, class I, G	Homo sapiens	78-83
15363998-7	2004	It is concluded that the beta3-adrenoceptor subtype, as well as dopamine D2/D1 receptors, is responsible for the increase in oxygen consumption induced by bupropion.	Oxygen	125-131	adrenoceptor beta 3	Rattus norvegicus	25-43
15194705-0	2004	Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.	Oxygen	25-31	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	42-68
15194705-0	2004	Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.	Oxygen	25-31	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	70-76
15194705-2	2004	Unusually for heme biosynthetic enzymes, CPO exists in two evolutionarily and mechanistically distinct families, with eukaryotes and some prokaryotes employing members of the highly conserved oxygen-dependent CPO family.	Oxygen	192-198	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	41-44
15194705-2	2004	Unusually for heme biosynthetic enzymes, CPO exists in two evolutionarily and mechanistically distinct families, with eukaryotes and some prokaryotes employing members of the highly conserved oxygen-dependent CPO family.	Oxygen	192-198	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	209-212
15194705-3	2004	Here, we report the crystal structure of the oxygen-dependent CPO from Saccharomyces cerevisiae (Hem13p), which was determined by optimized sulfur anomalous scattering and refined to a resolution of 2.0 A.	Oxygen	45-51	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	62-65
15194705-3	2004	Here, we report the crystal structure of the oxygen-dependent CPO from Saccharomyces cerevisiae (Hem13p), which was determined by optimized sulfur anomalous scattering and refined to a resolution of 2.0 A.	Oxygen	45-51	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	97-103
15341671-10	2004	CONCLUSIONS: Hypoxia is an inducer of the NDRG1 gene, and nickel probably causes the induction of the gene by interacting with the oxygen sensory pathway.	Oxygen	131-137	N-myc downstream regulated 1	Homo sapiens	42-47
15288804-6	2004	Both inhibitors were metabolized preferentially at their C-5 phenyl substituents, indicating that CYP2C19 prefers to orient the N-3 substituents away from the active oxygen species.	Oxygen	166-172	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	98-105
15341590-7	2004	This is the first demonstration that BDNF, in addition to modifying neuronal plasticity, can modify brain metabolism and the efficiency of oxygen utilization.	Oxygen	139-145	brain-derived neurotrophic factor	Rattus norvegicus	37-41
15315460-2	2004	The other cofacial dicobalt porphyrins [Co(2)(DPA), Co(2)(DPB), and Co(2)(DPD)] also catalyze the two-electron reduction of dioxygen, but the four-electron reduction is not as efficient as in the case of Co(2)(DPX).	Oxygen	124-132	dihydropyrimidine dehydrogenase	Homo sapiens	74-77
15217912-16	2004	In conclusion, Kv1.5 and Kv2.1 account for virtually all the O2-sensitive current.	Oxygen	61-63	potassium voltage-gated channel subfamily B member 1	Homo sapiens	25-30
15323727-2	2004	Atomic scale STM images show significant magnetic contrast corresponding to variations in the local surface states induced by oxygen vacancies.	Oxygen	126-132	sulfotransferase family 1A member 3	Homo sapiens	13-16
15234672-9	2004	In addition, hypoxic ventilatory depression was attenuated in PAFR -/- mice (P &lt; 0.01), and was primarily due to attenuation of the time-dependent decreases in oxygen consumption during sustained hypoxia (P &lt; 0.01).	Oxygen	163-169	platelet-activating factor receptor	Mus musculus	62-66
15265336-4	2004	For Sa(O2) of 97% versus 87%, [Hb] and a-v oxygen content difference increased (respectively, 14.5 to 17.5 g/100 mL and 4.11 to 5.03 volume %).	Oxygen	43-49	immunoglobulin kappa variable 1D-39	Homo sapiens	4-9
15265336-7	2004	The results suggest that increasing [Hb] allows greater oxygen extraction (a cardiac output sparing effect), which is maximal at Sa(O2) of 87% and a [Hb] of 17.5 g/100 mL.	Oxygen	56-62	immunoglobulin kappa variable 1D-39	Homo sapiens	129-134
15265336-8	2004	For more severe hypoxemia, even to Sa(O2) of 66%, both increasing [Hb] and increasing output are utilized for oxygen transport.	Oxygen	110-116	immunoglobulin kappa variable 1D-39	Homo sapiens	35-40
15469094-0	2004	[Current progress of a novel oxygen-binding protein: neuroglobin].	Oxygen	29-35	neuroglobin	Homo sapiens	53-65
15196028-1	2004	Symmetrical FeZn hybrids of human HbA have been used to measure K(1)(alpha) and K(1)(beta), the dissociation constants for the binding of a single molecule of oxygen to unliganded HbA at an alpha subunit and at a beta subunit, respectively.	Oxygen	159-165	keratin 90, pseudogene	Homo sapiens	180-183
15196028-6	2004	These results require a negative thermodynamic linkage between the binding of a single oxygen at either an alpha or a beta subunit and the binding of IHP to the T quaternary structure of HbA.	Oxygen	87-93	keratin 90, pseudogene	Homo sapiens	187-190
15162502-1	2004	Hypoxia-inducible factor 1alpha (HIF-1alpha) plays a central role in regulating oxygen-dependent gene expression and is involved in a range of pathways implicated in cellular survival, proliferation, and development.	Oxygen	80-86	hypoxia inducible factor 1 subunit alpha L homeolog	Xenopus laevis	33-43
15527170-7	2004	In conclusion, the decrease in E-selectin expression on the surface of pulmonary endothelium after LPS could contribute to decreased inflammation in this model of oxygen toxicity.	Oxygen	163-169	selectin E	Rattus norvegicus	31-41
15135139-0	2004	Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.	Oxygen	66-72	vascular endothelial growth factor A	Mus musculus	14-18
15135139-12	2004	Furthermore, secretion of VEGF protein was significantly enhanced under 0.5% oxygen.	Oxygen	77-83	vascular endothelial growth factor A	Mus musculus	26-30
15135139-14	2004	Furthermore, the soluble isoforms VEGF(120)and VEGF(164)are the most abundantly expressed splice variants in chondrocytes exposed to low oxygen levels.	Oxygen	137-143	vascular endothelial growth factor A	Mus musculus	34-38
15135139-14	2004	Furthermore, the soluble isoforms VEGF(120)and VEGF(164)are the most abundantly expressed splice variants in chondrocytes exposed to low oxygen levels.	Oxygen	137-143	vascular endothelial growth factor A	Mus musculus	47-51
14715486-3	2004	Hypoxia stimulated AM mRNA expression significantly in rat inner medulla (CO 13 times, 8% O(2) 6 times, and CoCl(2) 8 times), followed by the outer medulla and cortex.	Oxygen	90-94	adrenomedullin	Rattus norvegicus	19-21
14715486-11	2004	In summary, AM expression was increased in the rat kidney in response to hypoxic and ischemic hypoxia in keeping with oxygen gradients.	Oxygen	118-124	adrenomedullin	Rattus norvegicus	12-14
15171291-3	2004	X-ray diffraction and spectroscopic studies indicate that Cr6+ reacts with the ammonium pyrrolidinedithiocarbamate ligand to form two products, Cr(PDC)2(OPDC) and Cr(PDC)3, where OPDC represents an oxygen insertion between Cr and S atoms.	Oxygen	198-204	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	58-61
15063924-1	2004	In addition to its basic role in the metabolism of purine nucleotides, xanthine oxidoreductase (XOR) is involved in the generation of oxygen-derived free radicals and production and metabolic fate of nitric oxide (NO).	Oxygen	134-140	xanthine dehydrogenase	Bos taurus	71-94
15063924-1	2004	In addition to its basic role in the metabolism of purine nucleotides, xanthine oxidoreductase (XOR) is involved in the generation of oxygen-derived free radicals and production and metabolic fate of nitric oxide (NO).	Oxygen	134-140	xanthine dehydrogenase	Bos taurus	96-99
15096054-7	2004	A decrease in the suspension pH to 2 resulted in significant alterations in the MSP structure possibly because of protonation of unprotonated residues at lower pH, suggesting the existence of a large number of unprotonated amino acid residues at neutral pH possibly useful for proton transport in oxygen evolution.	Oxygen	297-303	microseminoprotein beta	Homo sapiens	80-83
15096054-9	2004	Thus, pH-induced structural changes of stable MSP (pH 6-4) may be utilized to analyze its functionality as a cofactor for oxygen evolution.	Oxygen	122-128	microseminoprotein beta	Homo sapiens	46-49
15875368-3	2004	Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system.	Oxygen	188-194	hydroxyacid oxidase 1	Homo sapiens	158-173
15875368-3	2004	Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system.	Oxygen	188-194	hydroxyacid oxidase 1	Homo sapiens	175-178
15080705-9	2004	The differential reactivity pattern between the Cu(II)(M)-OOH and Cu(II)(M)-superoxo intermediates provides insight into the role of the noncoupled nature of PHM and dopamine beta-monooxygenase active sites, as compared to the coupled binuclear Cu active sites in hemocyanin, tyrosinase, and catechol oxidase, in O(2) activation.	Oxygen	313-317	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	158-161
15080705-9	2004	The differential reactivity pattern between the Cu(II)(M)-OOH and Cu(II)(M)-superoxo intermediates provides insight into the role of the noncoupled nature of PHM and dopamine beta-monooxygenase active sites, as compared to the coupled binuclear Cu active sites in hemocyanin, tyrosinase, and catechol oxidase, in O(2) activation.	Oxygen	313-317	tyrosinase	Homo sapiens	276-286
15030976-5	2004	The iron-induced cell injury was oxygen-dependent, and although it was not inhibitable by extracellular catalase, it was strongly inhibited by the novel membrane-permeable catalase mimic TAA-1/Fe.	Oxygen	33-39	PVR cell adhesion molecule	Rattus norvegicus	187-192
15113568-7	2004	In fact, the triple mutant gpp1 Delta gpp2 Delta pdc2 Delta overexpressing GPD1 accumulated 17 mg L-G3P/g dry weight during glucose batch fermentation under oxygen limitation.	Oxygen	157-163	glycerol-1-phosphatase HOR2	Saccharomyces cerevisiae S288C	27-59
15113568-7	2004	In fact, the triple mutant gpp1 Delta gpp2 Delta pdc2 Delta overexpressing GPD1 accumulated 17 mg L-G3P/g dry weight during glucose batch fermentation under oxygen limitation.	Oxygen	157-163	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	75-79
15032831-5	2004	Spectroscopic determinations of cytochrome b(559) during photoinhibitory treatment showed slower kinetics of Cu (II) effect on cytochrome b(559) in comparison with the rapid loss of oxygen evolution activity in the same conditions.	Oxygen	182-188	mitochondrially encoded cytochrome b	Homo sapiens	32-44
14982461-4	2004	The reduced cobalt(II) complex, [(TBP)(8)CzCo(II)(py)](-), has been generated in situ and shown to bind dioxygen at low temperature to give [(TBP)(8)CzCo(III)(py)(O(2))](-).	Oxygen	104-112	TATA-box binding protein	Homo sapiens	34-37
14982461-4	2004	The reduced cobalt(II) complex, [(TBP)(8)CzCo(II)(py)](-), has been generated in situ and shown to bind dioxygen at low temperature to give [(TBP)(8)CzCo(III)(py)(O(2))](-).	Oxygen	104-112	TATA-box binding protein	Homo sapiens	142-145
14982461-6	2004	Exposure of [(TBP)(8)CzCo(II)(py)](-) to O(2) leads to the reversible formation of the cobalt(III)-superoxo complex [(TBP)(8)CzCo(III)(py)(O(2))](-), which has been characterized by EPR spectroscopy.	Oxygen	41-45	TATA-box binding protein	Homo sapiens	14-17
14982461-6	2004	Exposure of [(TBP)(8)CzCo(II)(py)](-) to O(2) leads to the reversible formation of the cobalt(III)-superoxo complex [(TBP)(8)CzCo(III)(py)(O(2))](-), which has been characterized by EPR spectroscopy.	Oxygen	41-45	TATA-box binding protein	Homo sapiens	118-121
14522819-7	2004	The quantitative measurement of oxygen consumption is made possible by our ability to independently measure the saturations of hemoglobin (Hb) and myoglobin (Mb) from optical spectra.	Oxygen	32-38	myoglobin	Mus musculus	147-156
14565964-4	2004	Compared with air-exposed control animals, 8-iso-PGF(2a) induced a significantly greater force (P &lt; 0.01) and reduced (P &lt; 0.01) relaxation of precontracted pulmonary arteries in the 60% O2-treated animals.	Oxygen	193-195	placental growth factor	Rattus norvegicus	49-52
14565964-8	2004	We speculate that impaired pulmonary vascular tissue NO metabolism after chronic O2 exposure potentiates 8-iso-PGF(2alpha)-induced vasoconstriction in the newborn rat, thus contributing to pulmonary hypertension.	Oxygen	81-83	placental growth factor	Rattus norvegicus	111-114
14734750-4	2004	Exposure of mouse macrophages to low oxygen tension resulted in the down-regulation of constitutive MCP-1 mRNA expression and protein secretion.	Oxygen	37-43	chemokine (C-C motif) ligand 2	Mus musculus	100-105
14670630-0	2004	Glucose/oxygen deprivation induces the alteration of synapsin I and phosphosynapsin.	Oxygen	8-14	synapsin I	Homo sapiens	53-63
14670630-4	2004	However, the neuronal damage and the changes in synapsin I as well as its phosphorylation level as a result of glucose/oxygen deprivation (GOD) and reperfusion in organotypic hippocampal slice cultures have not been established.	Oxygen	119-125	synapsin I	Homo sapiens	48-58
14709038-1	2004	The reaction between (TBP)8(Cz)Mn(III) (1) and the oxygen atom donors iodosylbenzene (PhIO) or p-cyanodimethylaniline-N-oxide (CDMANO) leads to the manganese(V)-oxo complex (TBP)8(Cz)Mn(V)O (2), which has been isolated and characterized previously.	Oxygen	51-57	TATA-box binding protein	Homo sapiens	22-25
14709038-1	2004	The reaction between (TBP)8(Cz)Mn(III) (1) and the oxygen atom donors iodosylbenzene (PhIO) or p-cyanodimethylaniline-N-oxide (CDMANO) leads to the manganese(V)-oxo complex (TBP)8(Cz)Mn(V)O (2), which has been isolated and characterized previously.	Oxygen	51-57	TATA-box binding protein	Homo sapiens	174-177
14709077-7	2004	The transition structure for oxygen atom transfer is fully optimized [B3LYP/6-31+G(d,p)] and has a classical activation barrier of 24.9 kcal/mol.	Oxygen	29-35	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	72-75
15205572-8	2004	Catalase, glutathione peroxidase, total and manganese superoxide dismutase activities as well as manganese superoxide dismutase (MnSOD) mRNA expression were elevated in both O2 groups after 7 days compared to the air groups (p &lt; 0.05) and MnSOD mRNA expression was elevated in the O2/dexamethasone group, but there were no differences between dexamethasone and saline groups in O2.	Oxygen	174-176	superoxide dismutase 2	Rattus norvegicus	44-74
15205572-8	2004	Catalase, glutathione peroxidase, total and manganese superoxide dismutase activities as well as manganese superoxide dismutase (MnSOD) mRNA expression were elevated in both O2 groups after 7 days compared to the air groups (p &lt; 0.05) and MnSOD mRNA expression was elevated in the O2/dexamethasone group, but there were no differences between dexamethasone and saline groups in O2.	Oxygen	174-176	superoxide dismutase 2	Rattus norvegicus	97-127
15205572-8	2004	Catalase, glutathione peroxidase, total and manganese superoxide dismutase activities as well as manganese superoxide dismutase (MnSOD) mRNA expression were elevated in both O2 groups after 7 days compared to the air groups (p &lt; 0.05) and MnSOD mRNA expression was elevated in the O2/dexamethasone group, but there were no differences between dexamethasone and saline groups in O2.	Oxygen	174-176	superoxide dismutase 2	Rattus norvegicus	129-134
15205572-8	2004	Catalase, glutathione peroxidase, total and manganese superoxide dismutase activities as well as manganese superoxide dismutase (MnSOD) mRNA expression were elevated in both O2 groups after 7 days compared to the air groups (p &lt; 0.05) and MnSOD mRNA expression was elevated in the O2/dexamethasone group, but there were no differences between dexamethasone and saline groups in O2.	Oxygen	174-176	superoxide dismutase 2	Rattus norvegicus	242-247
15205573-0	2004	Endothelin B receptor blockade attenuates pulmonary vasodilation in oxygen-ventilated fetal lambs.	Oxygen	68-74	endothelin receptor type B	Ovis aries	0-21
14720324-6	2004	Expression of VEGF-D mRNA was increased under low oxygen conditions, and all six cell lines constitutively expressed VEGF-D mRNA under hypoxic conditions.	Oxygen	50-56	vascular endothelial growth factor D	Homo sapiens	14-20
15239708-6	2004	The mechanism(s) of sporicidal activity of the KMT reagent was considered to be based on active iodine species penetrating the spores with enhanced permeability of the spore cortex by a synergistic effect of acid, ethanol and generated active oxygen.	Oxygen	243-249	calmodulin-lysine N-methyltransferase	Homo sapiens	47-50
15036292-1	2004	Neuroglobin displays a hexacoordination His-Fe-His in the absence of external ligands such as oxygen.	Oxygen	94-100	neuroglobin	Homo sapiens	0-11
15036292-7	2004	Mutation of specific cysteines, or reduction to break the S-S bond, led to a large decrease in the observed oxygen affinity of human neuroglobin, mainly due to a decrease in the histidine dissociation rate.	Oxygen	108-114	neuroglobin	Homo sapiens	133-144
15036293-2	2004	Augmenting O2 supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage.	Oxygen	11-13	neuroglobin	Homo sapiens	22-33
15036293-5	2004	Hexacoordinated human neuroglobin displays a classical globin fold, adapted to host the reversible bis-histidyl heme complex, and an elongated protein matrix cavity, held to facilitate O2 diffusion to the heme.	Oxygen	185-187	neuroglobin	Homo sapiens	22-33
14623476-4	2003	Phenol could be oxidized by dissolving oxygen in presence of immobilized tyrosinase to form a detectable product, which was determined at -150 mV without any mediator.	Oxygen	39-45	tyrosinase	Homo sapiens	73-83
12966104-9	2003	In the context of the open and fully solvent-accessible active site for the homologous peptidylglycine-alpha-hydroxylating monooxygenase and by analogy to cytochrome P-450, the accumulation of a reduced and activated oxygen species in DbetaM before C-H cleavage would be expected to give some uncoupling of oxygen and substrate consumption.	Oxygen	217-223	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	87-136
14506252-12	2003	Moreover, the overexpression of an oxygen-insensitive mutant form of HIFalpha resulted in increased normoxic levels of EGLN3 mRNA.	Oxygen	35-41	egl-9 family hypoxia inducible factor 3	Homo sapiens	119-124
14641050-12	2003	The site of single-electron deviation to dioxygen was found to be ubiquinol interacting with the Rieske iron-sulphur protein and low-potential cytochrome b of the bc (1) complex.	Oxygen	41-49	mitochondrially encoded cytochrome b	Homo sapiens	143-155
14645516-7	2003	We thus demonstrate two distinct cell cycle responses to low oxygen and suggest that alterations that lead to increased E2F can overcome hypoxic G1 arrest but that additional alterations, promoted by E1a expression, are necessary for neoplastic cells to proliferate despite anoxia.	Oxygen	61-67	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	200-203
12958058-8	2003	These findings indicate that cigarette smoke can directly induce airway remodeling, specifically airway wall fibrosis, probably through active oxygen species-dependent transactivation of the epidermal growth factor receptor and subsequent nuclear factor-kappaB activation.	Oxygen	143-149	epidermal growth factor receptor	Rattus norvegicus	191-223
14500549-0	2003	Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene.	Oxygen	24-30	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	57-85
14500549-2	2003	However, exposure to supplemental oxygen, a common therapeutic modality for lung disease, represses the expression of CCSP in the adult mouse lung.	Oxygen	34-40	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	118-122
12820982-2	2003	We studied the effect of selective glutamate receptor antagonists on the release of [3H]noradrenaline evoked by glucose and oxygen deprivation in hippocampal CA1, CA3 and dentate gyrus subregions.	Oxygen	124-130	carbonic anhydrase 1	Homo sapiens	158-161
14530476-9	2003	The heart-to-mediastinum uptake ratio of the delayed (123)I-MIBG image (1.00 - 1.72; mean +/- SD, 1.30 +/- 0.19) correlated with NE(CS-A) at peak exercise (r = 0.80, P &lt; 0.01) and peak heart rate (r = 0.73, P &lt; 0.01) but not with peak oxygen uptake.	Oxygen	241-247	chorionic somatomammotropin hormone 1	Homo sapiens	129-136
12907163-3	2003	High oxygen levels lead to downregulation of vascular endothelial growth factor (VEGF), an important survival factor for vascular endothelial cells, which could explain the vaso-obliteration caused by hyperoxia.	Oxygen	5-11	vascular endothelial growth factor A	Mus musculus	45-79
12907163-3	2003	High oxygen levels lead to downregulation of vascular endothelial growth factor (VEGF), an important survival factor for vascular endothelial cells, which could explain the vaso-obliteration caused by hyperoxia.	Oxygen	5-11	vascular endothelial growth factor A	Mus musculus	81-85
12958623-5	2003	Active oxygen species sustained the increased MMP-9 activity for at least 24 h. In the post-hypoxic period 20 micro mol/L H(2)O(2) caused a 6-fold increase in the specific activity of MMP-9 over the normoxic cells and a comparable effect was exerted by thrombin (50 nmol/L) and leukocyte elastase (10 nmol/L).	Oxygen	7-13	matrix metallopeptidase 9	Homo sapiens	46-51
12958623-5	2003	Active oxygen species sustained the increased MMP-9 activity for at least 24 h. In the post-hypoxic period 20 micro mol/L H(2)O(2) caused a 6-fold increase in the specific activity of MMP-9 over the normoxic cells and a comparable effect was exerted by thrombin (50 nmol/L) and leukocyte elastase (10 nmol/L).	Oxygen	7-13	matrix metallopeptidase 9	Homo sapiens	184-189
12962627-0	2003	Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity.	Oxygen	73-79	neuroglobin	Homo sapiens	12-23
12962627-2	2003	Augmenting O(2) supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage.	Oxygen	11-15	neuroglobin	Homo sapiens	24-35
12962627-5	2003	Hexacoordinated human neuroglobin displays a classical globin fold adapted to host the reversible bis-histidyl heme complex and an elongated protein matrix cavity, held to facilitate O(2) diffusion to the heme.	Oxygen	183-187	neuroglobin	Homo sapiens	22-33
12924938-0	2003	Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1.	Oxygen	177-179	heme oxygenase 1	Rattus norvegicus	73-89
12924938-0	2003	Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1.	Oxygen	177-179	heme oxygenase 1	Rattus norvegicus	91-95
12924938-0	2003	Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1.	Oxygen	177-179	heme oxygenase 1	Rattus norvegicus	183-187
12935887-5	2003	The oxygen uptake by the AA/nitrite/SCN(-) system was also observed in an acidic buffer solution.	Oxygen	4-10	sorcin	Homo sapiens	36-39
12805361-13	2003	Hence, in PC12 cells the level of HIF-2 alpha protein and its effect on gene expression can be down-regulated by stimuli other than oxygen.	Oxygen	132-138	endothelial PAS domain protein 1	Rattus norvegicus	34-45
12969758-9	2003	We thus assume that oxygen-free radicals may be closely related to the irradiation-induced derangement of the eNOS gene regulation.	Oxygen	20-26	nitric oxide synthase, endothelial	Oryctolagus cuniculus	110-114
12900059-2	2003	Incubation of neutrophils with SAA increased the rate of oxygen uptake and the production of reactive oxygen species of neutrophils activated with opsonized zymosan (OZ).	Oxygen	57-63	serum amyloid A1 cluster	Homo sapiens	31-34
12859624-8	2003	To investigate the potential biological applications of this chemistry the system was also examined by tyrosinase-catalysed oxidation of the catecholamine substrates in which there is re-oxidation of the catechol formed by the redox exchange reaction and enables measurement of oxygen utilization stoichiometry.	Oxygen	278-284	tyrosinase	Homo sapiens	103-113
14744374-12	2003	MPO activities in the 20 x 10(-6) iNO group under 100% O(2) were significantly reduced compared with those under 21%O(2) [(1.4 +/- 0.3) U/g vs (2.0 +/- 0.1) U/g, P &lt; 0.05].	Oxygen	55-59	myeloperoxidase	Oryctolagus cuniculus	0-3
14744374-12	2003	MPO activities in the 20 x 10(-6) iNO group under 100% O(2) were significantly reduced compared with those under 21%O(2) [(1.4 +/- 0.3) U/g vs (2.0 +/- 0.1) U/g, P &lt; 0.05].	Oxygen	116-120	myeloperoxidase	Oryctolagus cuniculus	0-3
12837085-18	2003	The H-beta-Ala"s amino group binds to the carboxyl group to form a salt bridge, while the Aib(3) NH is hydrogen-bonded to either oxygen of the carboxylate group.	Oxygen	129-135	ANIB1	Homo sapiens	90-93
12897817-7	2003	A significant aerobic conditioning effect in the EG was confirmed by a 17% increase in O2 pulse at peak exercise between Entry and TM3.	Oxygen	87-89	tropomyosin 3	Homo sapiens	131-134
12697836-6	2003	Caki-1 cells were exposed to hypoxia (1% O2) and exhibited increased Cdc42, Rac1 and RhoA protein expression.	Oxygen	41-43	Rac family small GTPase 1	Homo sapiens	76-80
12733060-1	2003	Fatty acid desaturation, which requires molecular oxygen (O2) as an electron acceptor, is catalyzed by delta9 fatty acid desaturase, which is encoded by OLE1 in Saccharomyces cerevisiae.	Oxygen	50-56	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	153-157
12733060-1	2003	Fatty acid desaturation, which requires molecular oxygen (O2) as an electron acceptor, is catalyzed by delta9 fatty acid desaturase, which is encoded by OLE1 in Saccharomyces cerevisiae.	Oxygen	58-60	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	153-157
12733060-9	2003	Furthermore, we found that not only the fatty acid- regulated (FAR) element but also the O2- regulated (O2R) element in the OLE1 promoter was involved in the activation of OLE1 transcription by the ole1-101 mutation, and that the effects of the low-oxygen signal and the ole1-101-generated signal on OLE1 expression were not additive.	Oxygen	249-255	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	124-128
12733060-9	2003	Furthermore, we found that not only the fatty acid- regulated (FAR) element but also the O2- regulated (O2R) element in the OLE1 promoter was involved in the activation of OLE1 transcription by the ole1-101 mutation, and that the effects of the low-oxygen signal and the ole1-101-generated signal on OLE1 expression were not additive.	Oxygen	249-255	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	172-176
12733060-9	2003	Furthermore, we found that not only the fatty acid- regulated (FAR) element but also the O2- regulated (O2R) element in the OLE1 promoter was involved in the activation of OLE1 transcription by the ole1-101 mutation, and that the effects of the low-oxygen signal and the ole1-101-generated signal on OLE1 expression were not additive.	Oxygen	249-255	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	198-202
12733060-9	2003	Furthermore, we found that not only the fatty acid- regulated (FAR) element but also the O2- regulated (O2R) element in the OLE1 promoter was involved in the activation of OLE1 transcription by the ole1-101 mutation, and that the effects of the low-oxygen signal and the ole1-101-generated signal on OLE1 expression were not additive.	Oxygen	249-255	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	172-176
12750003-2	2003	Oxygen-derived free radicals trigger DNA strand damage, which is responsible for the activation of poly(ADP-ribose) polymerase (PARP).	Oxygen	0-6	poly (ADP-ribose) polymerase family, member 1	Mus musculus	99-126
12750003-2	2003	Oxygen-derived free radicals trigger DNA strand damage, which is responsible for the activation of poly(ADP-ribose) polymerase (PARP).	Oxygen	0-6	poly (ADP-ribose) polymerase family, member 1	Mus musculus	128-132
12729929-6	2003	Power saturation EPR experiments indicate that for the sample compositions described here, the spin-lattice relaxation rate of the CLS spin label was increased by varying amounts in the presence of different lanthanide (Gd(3+), Dy(3+), Er(3+), Yb(3+), and Tm(3+)) ions, and in the presence of molecular oxygen.	Oxygen	303-309	spindlin 1	Homo sapiens	95-99
12729929-6	2003	Power saturation EPR experiments indicate that for the sample compositions described here, the spin-lattice relaxation rate of the CLS spin label was increased by varying amounts in the presence of different lanthanide (Gd(3+), Dy(3+), Er(3+), Yb(3+), and Tm(3+)) ions, and in the presence of molecular oxygen.	Oxygen	303-309	spindlin 1	Homo sapiens	135-139
12752442-7	2003	The physiological meaning of the oxygen regulation of ERO1-Lalpha expression likely is to maintain the transfer rate of oxidizing equivalents to PDI in situations of an altered cellular redox state induced by changes of the cellular oxygen tension.	Oxygen	33-39	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	145-148
12752442-7	2003	The physiological meaning of the oxygen regulation of ERO1-Lalpha expression likely is to maintain the transfer rate of oxidizing equivalents to PDI in situations of an altered cellular redox state induced by changes of the cellular oxygen tension.	Oxygen	233-239	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	145-148
12832031-6	2003	The ADRB2 Glu27Glu subjects had lower plasma glycerol levels (P = 0.026), while plasma triglycerides (P &lt;0.001) and the insulin:glucose ratio were higher (P = 0.046) as compared to the Gln27Gln group along the peak oxygen consumption trial intervention.	Oxygen	218-224	adrenoceptor beta 2	Homo sapiens	4-9
12911193-2	2003	Methemoglobin is incapable of carrying O2, and high levels may impact on O2 delivery to the tissues.	Oxygen	39-41	hemoglobin subunit gamma 2	Homo sapiens	0-13
12911193-2	2003	Methemoglobin is incapable of carrying O2, and high levels may impact on O2 delivery to the tissues.	Oxygen	73-75	hemoglobin subunit gamma 2	Homo sapiens	0-13
12667640-6	2003	AM plays an important role in environments subjected to low oxygen tensions, which is a typical feature in the proximity of solid tumors.	Oxygen	60-66	adrenomedullin	Homo sapiens	0-2
12615973-10	2003	Endogenous PHD2mRNA and PHD3mRNA were hypoxia-inducible, whereas expression of PHD1mRNA and FIH-1mRNA was oxygen independent.	Oxygen	106-112	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	92-97
12615973-11	2003	We propose that PHDs and FIH-1 form an oxygen sensor cascade of distinct subcellular localisation.	Oxygen	39-45	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	25-30
12620835-3	2003	Both UFAs are formed in S. cerevisiae by the oxygen- and NADH-dependent desaturation of palmitic acid (C(16:0)) and stearic acid (C(18:0)), respectively, catalyzed by a single integral membrane desaturase encoded by the OLE1 gene.	Oxygen	45-51	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	220-224
12643758-8	2003	The oxygen affinity of Hb is increased slightly on PEGylation, but the length of the PEG-chain had very little additional influence on the O(2) affinity.	Oxygen	4-10	PEG	Bos taurus	51-54
12643758-14	2003	Thus, the biochemically homogeneous PEGylated Hbs described in the present study, surface-decorated with PEG chains of appropriate size, could serve as potential candidates for Hb-based oxygen carriers.	Oxygen	186-192	PEG	Bos taurus	36-39
12706409-1	2003	Chronic granulomatous disease (CGD) is a rare inherited disorder in which phagocytes are incapable of generating bactericidal-reactive oxygen derivatives.	Oxygen	135-141	cytochrome b-245 beta chain	Homo sapiens	31-34
12593649-3	2003	The scaffold comprising the sulfonyl keto piperazine moiety might play a pivotal role in the orientation of substituents, since there is a strong hydrogen bond between Gly219 of fXa and the carbonyl oxygen of the piperazine.	Oxygen	199-205	coagulation factor X	Homo sapiens	178-181
12409290-1	2003	Evidence for neuroglobin-mediated oxygen supply in the mammalian retina.	Oxygen	34-40	neuroglobin	Homo sapiens	13-24
12409290-7	2003	The distribution of neuroglobin correlates with the subcellular localization of mitochondria and with the relative oxygen demands, as the plexiform layers and the inner segment consume most of the retinal oxygen.	Oxygen	115-121	neuroglobin	Homo sapiens	20-31
12409290-7	2003	The distribution of neuroglobin correlates with the subcellular localization of mitochondria and with the relative oxygen demands, as the plexiform layers and the inner segment consume most of the retinal oxygen.	Oxygen	205-211	neuroglobin	Homo sapiens	20-31
12409290-8	2003	These findings suggest that neuroglobin supplies oxygen to the retina, similar to myoglobin in the myocardium and the skeletal muscle.	Oxygen	49-55	neuroglobin	Homo sapiens	28-39
14562759-7	2003	At this stage, the oxygen concentration in cerebral tissue fell to lower than 10(-7) M. These data suggest that the decline in oxidative phosphorylation might be a trigger for the induction of c-fos mRNA.	Oxygen	19-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-198
14504446-3	2003	In the CB of 1-day-old rabbits, D2- and D1-R transcript levels increased and decreased after exposure to 15 and 8% O2, respectively.	Oxygen	115-117	D(1A) dopamine receptor	Oryctolagus cuniculus	40-44
12401520-6	2003	Conclusively, we present that both the disturbances of mitochondrial calcium homeostasis and reactive oxygen intermediates are essential for rapid transactivation of grp78, and this pathway is separate from protein kinase A (PKA)-dependent CREB activation or p38 mitogen-activated protein kinase (p38(MAPK))-dependent ATF-2 activation and signalling.	Oxygen	102-108	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	166-171
14753546-3	2003	However, when using this method with biodegradable compounds some difficulties arise because the PTI consumption implies oxygen consumption as well.	Oxygen	121-127	serpin family B member 6	Homo sapiens	97-100
12480817-4	2002	In the present study, electron spin resonance spectroscopy is utilized to demonstrate that VEGF stimulates O2*- production, which is inhibited by the NAD(P)H oxidase inhibitor, diphenylene iodonium, as well as by overexpression of dominant-negative Rac1 (N17Rac1) and transfection of gp91(phox) antisense oligonucleotides in human umbilical vein endothelial cells (ECs).	Oxygen	107-109	Rac family small GTPase 1	Homo sapiens	249-253
12515318-0	2002	Activation of BDNF mRNA and protein after seizures in hyperbaric oxygen: implications for sensitization to seizures in re-exposures.	Oxygen	65-71	brain-derived neurotrophic factor	Rattus norvegicus	14-18
12515318-3	2002	In this study, a fast induction in BDNF mRNA 2 hr after seizures and a temporary increase in BDNF protein 1 day after seizures induced by 100% O2 at 5 atm (gauge pressure) were demonstrated in the rat cortex.	Oxygen	143-145	brain-derived neurotrophic factor	Rattus norvegicus	93-97
12440977-2	2002	OLE1 expression is regulated at the levels of transcription and mRNA stability by nutrient fatty acids and molecular oxygen.	Oxygen	117-123	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
12384583-8	2002	In addition, the amino group of C formed a hydrogen bond with the phosphate oxygen of A. G adopted a syn orientation about the glycosidic bond, while the sugar puckers of A and C were either C2"-endo or flexible.	Oxygen	76-82	synemin	Homo sapiens	101-104
12397475-6	2002	CrN layers produced at low sputter power have much higher concentration of oxygen than layers produced with high sputter power.	Oxygen	75-81	crooked neck pre-mRNA splicing factor 1	Homo sapiens	0-3
12207011-5	2002	Exposure to DETA-NO resulted in a rapid and profound inhibition of cell respiration (78.3 +/- 6.4%), whereas NCX-4016 caused a less pronounced reduction in oxygen consumption (43.5 +/- 5.3%).	Oxygen	156-162	T cell leukemia homeobox 2	Homo sapiens	109-112
12238567-6	2002	Expression of the neutrophil adhesion molecule, L-selectin, was lower at 4 and 24 hr in the endotoxin-treated rats compared to O2 controls.	Oxygen	127-129	selectin L	Rattus norvegicus	48-58
12244198-6	2002	The intracellular formation of bactericidal oxygen species proved to be MyD88 dependent; however, uptake of GBS, a prerequisite for intracellular killing by O(2) radicals, occurred independently of MyD88.	Oxygen	44-50	myeloid differentiation primary response gene 88	Mus musculus	72-77
12242265-8	2002	Kv2.1 adenoviral gene-transfer significantly reverses ionic remodeling, partially restoring both the electrophysiological and tone responses to 4-AP and O2.	Oxygen	153-155	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
12181152-8	2002	Myocardial eNOS protein expression is transiently increased during pregnancy in rats, and this increase is associated with enhanced NO-dependent control of myocardial oxygen consumption at a time when cardiac output is increased.	Oxygen	167-173	nitric oxide synthase 3	Rattus norvegicus	11-15
12176051-1	2002	Members of the Quiescin-sulfhydryl oxidase (QSOX) family utilize a thioredoxin domain and a small FAD-binding domain homologous to the yeast ERV1p protein to oxidize sulfhydryl groups to disulfides with the reduction of oxygen to hydrogen peroxide.	Oxygen	220-226	quiescin sulfhydryl oxidase 1	Homo sapiens	44-48
12200115-7	2002	Severe oxygen mediated inhibition (92% inhibition) of RDX biotransformation and superoxide dismutase-sensitive cytochrome c reduction indicated the potential involvement of an anion radical RDX(.-) prior to denitration.	Oxygen	7-13	radixin	Homo sapiens	54-57
12200115-7	2002	Severe oxygen mediated inhibition (92% inhibition) of RDX biotransformation and superoxide dismutase-sensitive cytochrome c reduction indicated the potential involvement of an anion radical RDX(.-) prior to denitration.	Oxygen	7-13	radixin	Homo sapiens	190-193
12190496-3	2002	The moment on the oxygen arises from the strong hybridization between the Ru-4d and O-2p orbitals.	Oxygen	18-24	immunoglobulin kappa variable 1D-39	Homo sapiens	84-88
12148977-0	2002	Active-site stereochemical control of oxygen atom transfer reactivity in sulfite oxidase.	Oxygen	38-44	sulfite oxidase	Homo sapiens	73-88
12023289-1	2002	Our previous results run counter to the hypothesis that S-nitrosohemoglobin (SNO-Hb) serves as an in vivo reservoir for NO from which NO release is allosterically linked to oxygen release.	Oxygen	173-179	strawberry notch homolog 2	Homo sapiens	77-80
12023289-5	2002	The elevated levels of intra-erythrocytic SNO-Hb fell rapidly, independent of oxygen tension and hemoglobin saturation.	Oxygen	78-84	strawberry notch homolog 2	Homo sapiens	42-45
12139543-2	2002	It is unknown, however, which CPAP levels are required to avoid alveolar derecruitment and to consistently improve pulmonary oxygen transfer in patients following thoracotomy.	Oxygen	125-131	centromere protein J	Homo sapiens	30-34
12130498-4	2002	In support, hemoglobin in plasma, when oxidized to methemoglobin by oxidants such as leukocyte-derived reactive oxygen, causes oxidative modification of LDL.	Oxygen	112-118	hemoglobin subunit gamma 2	Homo sapiens	51-64
11994311-5	2002	In related GCN5 family structures, a hydroxyl-containing side chain residue is hydrogen-bonded to the alpha-phosphate oxygen of CoA.	Oxygen	118-124	lysine acetyltransferase 2A	Homo sapiens	11-15
12089367-3	2002	In vitro, the oxygen-regulated subunits HIF-1alpha and -2alpha are expressed in inverse relationship to oxygen tensions in every cell line investigated to date.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-62
12089367-3	2002	In vitro, the oxygen-regulated subunits HIF-1alpha and -2alpha are expressed in inverse relationship to oxygen tensions in every cell line investigated to date.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	40-62
12082608-5	2002	Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines.	Oxygen	0-6	growth differentiation factor 15	Homo sapiens	59-64
12054988-1	2002	A comparison of the structure, spectroscopy, and oxygen atom-transfer reactivity of cofacial bisporphyrins anchored by xanthene (DPX) and dibenzofuran (DPD) pillars is presented.	Oxygen	49-55	dihydropyrimidine dehydrogenase	Homo sapiens	152-155
12054988-7	2002	A structure-function relation is developed for the photoinduced oxygen atom-transfer reactions of bisiron(III) mu-oxo derivatives of DPX and DPD.	Oxygen	64-70	dihydropyrimidine dehydrogenase	Homo sapiens	141-144
12044899-2	2002	Genetic engineering of the active site of CcP, along with structural, spectroscopic, and kinetic characterization of the mutant proteins has provided considerable insight into the mechanism of hydrogen peroxide activation, oxygen-oxygen bond cleavage, and formation of the higher-oxidation state intermediates in heme enzymes.	Oxygen	223-229	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	42-45
12003775-3	2002	In this study, we investigated lung PTHrP after injury induced by &gt;95% oxygen in rats and rabbits.	Oxygen	74-80	parathyroid hormone-like hormone	Rattus norvegicus	36-41
11959481-3	2002	Dopamine is oxidized by oxygen under the catalysis of polyphenol oxidase in the tissue column to produce hydrogen peroxide, which can react with luminol in the presence of peroxidase of potato tissue to generate CL signal.	Oxygen	24-30	peroxidase N1	Solanum tuberosum	172-182
12186752-0	2002	Sulfo-SADP (sulfosuccinimidyl[4-azidophenyldithio]propionate) an active site directed reagent inhibiting the NADPH dependent O2- generation of leukocyte cytochrome b(558).	Oxygen	125-127	mitochondrially encoded cytochrome b	Homo sapiens	153-165
12186752-2	2002	One, ethyleneglycolbis[sulfo-succinimidylsuccinate], (sulfo-EGS) was found to inhibit O2- generation at concentrations which are known to result in cross-linking the two subunits of cytochrome b(558).	Oxygen	86-88	mitochondrially encoded cytochrome b	Homo sapiens	182-194
12186752-3	2002	Sulfosuccinimidyl [4-azidophenyldithio] propionate, (sulfo-SADP) on the other hand, was found to be a powerful inhibitor of the cytochrome b(558) dependent O2- production at concentrations not able to result in cross linking of the two subunits.	Oxygen	156-158	mitochondrially encoded cytochrome b	Homo sapiens	128-140
12186752-5	2002	For these reagents, the succinimidyl group of sulfo-SADP and sulfo-EGS is the reactive group, which inhibit irreversibly, cytochrome b(558) generation of O2-.	Oxygen	154-156	mitochondrially encoded cytochrome b	Homo sapiens	122-134
12040027-2	2002	cAMP induction of hSP-A2 expression is O2 dependent and mediated by increased phosphorylation, DNA binding, and transcriptional activation of thyroid transcription factor-1 (TTF-1).	Oxygen	39-41	surfactant protein A2	Homo sapiens	18-24
11980488-0	2002	Characteristic changes of the S2/S1 difference FTIR spectrum induced by Ca2+ depletion and metal cation substitution in the photosynthetic oxygen-evolving complex.	Oxygen	139-145	carbonic anhydrase 2	Homo sapiens	72-75
11980488-1	2002	Effects of Ca2+ depletion and substitution with other metal cations on the structure of the protein matrices of the oxygen-evolving complex (OEC) and their corresponding changes upon the S1 to S2 transition were examined using Fourier transform infrared (FTIR) spectroscopy.	Oxygen	116-122	carbonic anhydrase 2	Homo sapiens	11-14
11939775-8	2002	Like Co(2+), Fe(2+) bound to yeast ferrochelatase was coordinated by approximately six oxygen or nitrogen ligands, again with evidence of two histidine ligands.	Oxygen	87-93	ferrochelatase	Mus musculus	35-49
11984975-2	2002	The discovery of neuroglobin, protein varyingly present in the brain, has been enhanced by the elucidation of the mechanisms through which oxygen intervenes in neuronal metabolism.	Oxygen	139-145	neuroglobin	Homo sapiens	17-28
11878963-4	2002	The epimerization is likely initiated by the formation of Zn-enolate that is stabilized by intramolecular chelation to the pyranose ring-oxygen to form a syn chair-boat structure.	Oxygen	137-143	synemin	Homo sapiens	154-157
11874451-8	2002	The oxygen consumption of L6 cells under nonphosphorylating conditions increased concomitantly with the levels of UCP3 expression.	Oxygen	4-10	uncoupling protein 3	Homo sapiens	114-118
11963835-12	2002	The correlation between EPO and hematocrit suggests that blood oxygen content rather than oxygen tension is the more important stimulant for augmented EPO production after fetal hemorrhage.	Oxygen	63-69	erythropoietin	Ovis aries	24-27
11963835-12	2002	The correlation between EPO and hematocrit suggests that blood oxygen content rather than oxygen tension is the more important stimulant for augmented EPO production after fetal hemorrhage.	Oxygen	63-69	erythropoietin	Ovis aries	151-154
11846651-3	2002	The addition of dimethylacetylene dicarboxylate (DMAD) is influenced by the electrostatic repulsion arising from the interaction of an electron pair orbital on the acetal oxygen and the orthogonal pi-orbital of the acetylene unit in DMAD in the syn-to-oxygen addition of the latter.	Oxygen	171-177	synemin	Homo sapiens	245-248
11846651-3	2002	The addition of dimethylacetylene dicarboxylate (DMAD) is influenced by the electrostatic repulsion arising from the interaction of an electron pair orbital on the acetal oxygen and the orthogonal pi-orbital of the acetylene unit in DMAD in the syn-to-oxygen addition of the latter.	Oxygen	252-258	synemin	Homo sapiens	245-248
11846651-4	2002	This repulsion is offset on coordination of Li+ to the said oxygen electron pair orbital, and the addition thus proceeds syn to oxygen.	Oxygen	60-66	synemin	Homo sapiens	121-124
11846651-4	2002	This repulsion is offset on coordination of Li+ to the said oxygen electron pair orbital, and the addition thus proceeds syn to oxygen.	Oxygen	128-134	synemin	Homo sapiens	121-124
11846651-5	2002	The enhanced and accelerated syn-to-oxygen addition in lithium perchlorate in nitromethane is interpreted as a consequence of the coordination of Li+ to both the acetal oxygen and a heteroatom in the dienophile that brings them in close proximity to facilitate a reaction.	Oxygen	36-42	synemin	Homo sapiens	29-32
11834720-2	2002	Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension.	Oxygen	104-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	50-60
12205400-1	2002	Reactive oxygen species are reactive, partially reduced derivatives of molecular oxygen (O 2 ).	Oxygen	9-15	immunoglobulin kappa variable 1D-39	Homo sapiens	89-92
11818393-0	2002	Localization of VEGF receptor-2 (KDR/Flk-1) and effects of blocking it in oxygen-induced retinopathy.	Oxygen	74-80	vascular endothelial growth factor A	Canis lupus familiaris	16-20
11818393-2	2002	The goal of this study was to examine the immunohistochemical localization and relative levels of VEGF receptor-2 (KDR) in canine retina during postnatal vasculogenesis and during angiogenesis in oxygen-induced retinopathy (OIR) and to investigate the effects of neutralizing KDR on these processes.	Oxygen	196-202	vascular endothelial growth factor A	Canis lupus familiaris	98-102
11826181-4	2002	With a newly developed sensor, the oxygen fluxoptode, it has become possible to make local measurements of the transcutaneous oxygen flux (tcJ(O2)).	Oxygen	35-41	immunoglobulin kappa variable 1D-39	Homo sapiens	139-145
11826181-8	2002	At normal skin surface partial oxygen pressure (163 +/- 9 Torr), tcJ(O2) was 0.53 +/- 0.27 ml O2 min(-1) x m(-2).	Oxygen	31-37	immunoglobulin kappa variable 1D-39	Homo sapiens	65-71
11818497-6	2002	In contrast, expression of the putative mHIF-1alphaI.1 protein in spermatozoa of the testis and epididymis was oxygen independent and located to the midpiece of the spermatozoal flagellum.	Oxygen	111-117	protein phosphatase 1, regulatory inhibitor subunit 1A	Mus musculus	40-54
11848682-8	2002	We conclude that endogenous NT-3 enhanced neuronal injury during acute stroke, possible by increasing oxygen-radical mediated cell death.	Oxygen	102-108	neurotrophin 3	Homo sapiens	28-32
11929192-7	2002	While UCP1 has a clear role in energy homeostasis, the newcomers UCP2-UCP5 may have more delicate physiological importance acting as free radical oxygen scavengers and in the regulation of ATP-dependent processes, such as secretion.	Oxygen	146-152	solute carrier family 25 member 14	Homo sapiens	70-74
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	Oxygen	141-147	acyl-CoA oxidase 1	Homo sapiens	46-65
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	Oxygen	141-147	acyl-CoA oxidase 1	Homo sapiens	67-70
11839031-2	2002	At PTB the active balloons are destroyed by combustion in an oxygen stream.	Oxygen	61-67	polypyrimidine tract binding protein 1	Homo sapiens	3-6
12145629-1	2002	Neutrophil disfunction, caused by a decreased production of effective radical oxygen species by myeloperoxidase (MPO) and NADPH oxidase within the neutrophil, may result in susceptibility to opportunistic fungal infections.	Oxygen	78-84	myeloperoxidase	Mus musculus	113-116
12201123-13	2002	The relative flux decreased 10 and 20% with increasing chemical oxygen demand (COD) from 5,000 mgl-1 to 10,000 mgl-1 and from 45 mgl-1 to 450 mgl-1 for RO and NF membranes, respectively after 45 h of time.	Oxygen	64-70	LLGL scribble cell polarity complex component 1	Homo sapiens	95-100
12201123-13	2002	The relative flux decreased 10 and 20% with increasing chemical oxygen demand (COD) from 5,000 mgl-1 to 10,000 mgl-1 and from 45 mgl-1 to 450 mgl-1 for RO and NF membranes, respectively after 45 h of time.	Oxygen	64-70	LLGL scribble cell polarity complex component 1	Homo sapiens	111-116
12201123-13	2002	The relative flux decreased 10 and 20% with increasing chemical oxygen demand (COD) from 5,000 mgl-1 to 10,000 mgl-1 and from 45 mgl-1 to 450 mgl-1 for RO and NF membranes, respectively after 45 h of time.	Oxygen	64-70	LLGL scribble cell polarity complex component 1	Homo sapiens	111-116
12201123-13	2002	The relative flux decreased 10 and 20% with increasing chemical oxygen demand (COD) from 5,000 mgl-1 to 10,000 mgl-1 and from 45 mgl-1 to 450 mgl-1 for RO and NF membranes, respectively after 45 h of time.	Oxygen	64-70	LLGL scribble cell polarity complex component 1	Homo sapiens	111-116
11742077-3	2001	Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen and preferential localization to vertebrate brain.	Oxygen	83-89	neuroglobin	Homo sapiens	0-11
11742077-3	2001	Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen and preferential localization to vertebrate brain.	Oxygen	83-89	neuroglobin	Homo sapiens	13-16
11742085-4	2001	After 2 h of oxygen/glucose deprivation, BID cleavage was detected in neurons concurrent with caspase 8 activation but before caspase 3 cleavage.	Oxygen	13-19	caspase 3	Mus musculus	126-135
11750760-6	2001	The results suggest that GIF could act as an efficient scavenger against free radicals in vitro and the alpha-domain in GIF molecule shows more potential in protecting against reactive oxygen species injury than the beta-domain.	Oxygen	185-191	metallothionein 3	Homo sapiens	25-28
11750760-6	2001	The results suggest that GIF could act as an efficient scavenger against free radicals in vitro and the alpha-domain in GIF molecule shows more potential in protecting against reactive oxygen species injury than the beta-domain.	Oxygen	185-191	metallothionein 3	Homo sapiens	120-123
11757634-7	2001	MMP-9 activity correlated significantly with the oxygen tension in arterial blood/inspiratory oxygen fraction, the lung wet-to-dry weight ratio, and the number of neutrophils in BALF, whereas MMP-2 activity did not correlate at all with these factors.	Oxygen	49-55	matrix metallopeptidase 9	Sus scrofa	0-5
11757634-7	2001	MMP-9 activity correlated significantly with the oxygen tension in arterial blood/inspiratory oxygen fraction, the lung wet-to-dry weight ratio, and the number of neutrophils in BALF, whereas MMP-2 activity did not correlate at all with these factors.	Oxygen	94-100	matrix metallopeptidase 9	Sus scrofa	0-5
11767887-4	2001	After enriching the organic components on activated charcoal and pyrolysis in an oxygen stream at 950 degrees C, in accordance with DIN/EN 38409,H14/1485, interfering CO2 and H2O gas generated during combustion is removed from the analytes in the so-called ELSA-system (element-selective AOX-analyzer).	Oxygen	81-87	acyl-CoA oxidase 1	Homo sapiens	288-291
11807115-14	2001	However, in tadpoles, catalase may be responsive to environmental oxygen.	Oxygen	66-72	catalase	Gallus gallus	22-30
11681624-0	2001	Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1.	Oxygen	29-31	chromosome 20 open reading frame 181	Homo sapiens	135-163
11568308-0	2001	Reduced oxygen tension increases atrial natriuretic peptide release from atrial cardiocytes.	Oxygen	8-14	natriuretic peptide A	Rattus norvegicus	33-59
11568308-1	2001	To test the hypothesis that reduced oxygen tension stimulates cardiac atrial natriuretic peptide (ANP) secretion, we measured ANP release and expression in neonatal rat atrial and ventricular cardiac myocytes exposed to 45 min and 3, 6, and 24 hr of 3% or 21% oxygen.	Oxygen	36-42	natriuretic peptide A	Rattus norvegicus	70-96
11561216-1	2001	This study was designed to investigate the effects of cocaine-amphetamine-regulated transcript (CART), a recently discovered hypothalamic neuropeptide, on food intake, anxiety, oxygen consumption and gastric emptying in mice.	Oxygen	177-183	CART prepropeptide	Mus musculus	96-100
11561216-5	2001	Furthermore, the i. c. v. injection of CART significantly reduced oxygen consumption and gastric emptying rate.	Oxygen	66-72	CART prepropeptide	Mus musculus	39-43
11427531-9	2001	Cathepsin-B inhibitors rescue hippocampal slices from cell death induced by oxygen/glucose deprivation.	Oxygen	76-82	cathepsin B	Homo sapiens	0-11
11517313-4	2001	We find that, at biologically relevant O(2) concentrations, HMP preferentially binds NO (not O(2)), which it then reacts with oxygen to form nitrate (in essence NO(-) + O(2) --&gt; NO(3)(-)).	Oxygen	39-43	inner membrane mitochondrial protein	Homo sapiens	60-63
11517313-4	2001	We find that, at biologically relevant O(2) concentrations, HMP preferentially binds NO (not O(2)), which it then reacts with oxygen to form nitrate (in essence NO(-) + O(2) --&gt; NO(3)(-)).	Oxygen	126-132	inner membrane mitochondrial protein	Homo sapiens	60-63
11526200-0	2001	Oxygen-dependent expression of hypoxia-inducible factor-1alpha in renal medullary cells of rats.	Oxygen	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	31-62
11526200-1	2001	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31
11526200-1	2001	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes.	Oxygen	90-96	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
11506127-2	2001	Halothane is reduced under low oxygen tensions by CYP2A6 and CYP3A4 in human liver microsome to an unstable free radical, and then to the volatile metabolites chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE).	Oxygen	31-37	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	50-56
11498801-8	2001	These results indicate that MT, MIP-2, and MCP-1 mRNA levels responded similarly to recovery from nitrogen dioxide, oxygen, and ozone exposure.	Oxygen	116-122	chemokine (C-C motif) ligand 2	Mus musculus	43-48
11408455-7	2001	Together, these results indicate that HO-2 is present in the RVLM under control conditions and that HO-1 is induced in the RVLM during chronic hypoxia, consistent with a potential role for HO in the oxygen-sensing function of these cardiorespiratory RVLM regions.	Oxygen	199-205	heme oxygenase 1	Rattus norvegicus	100-104
11455199-1	2001	The recombinant forms of the two human isozymes of glutamate decarboxylase, GAD65 and GAD67, are potently and reversibly inhibited by molecular oxygen (Ki = 0.46 and 0.29 mM, respectively).	Oxygen	144-150	glutamate decarboxylase 1	Homo sapiens	86-91
11460539-7	2001	By preparative high-performance liquid chromatography as many as seven major products of oxygen attachment to Car have been isolated.	Oxygen	89-95	nuclear receptor subfamily 1 group I member 3	Homo sapiens	110-113
11460539-8	2001	Their molecular masses show that Car sequentially accumulates up to six oxygen atoms while its C40-skeleton remains intact.	Oxygen	72-78	nuclear receptor subfamily 1 group I member 3	Homo sapiens	33-36
11376856-7	2001	With a lesioning protocol that elicits minimal injury in wild-types (ligation+40 min 10% O2), there was an attenuation of hypoxia-ischemia-induced MCP-1 production at 8 h post-hypoxia; in contrast, in animals that underwent longer periods of hypoxia-ischemia the magnitude of injury-induced induced MCP-1 production did not differ between wild-type and ICE -/- animals.	Oxygen	89-91	chemokine (C-C motif) ligand 2	Mus musculus	147-152
11376856-7	2001	With a lesioning protocol that elicits minimal injury in wild-types (ligation+40 min 10% O2), there was an attenuation of hypoxia-ischemia-induced MCP-1 production at 8 h post-hypoxia; in contrast, in animals that underwent longer periods of hypoxia-ischemia the magnitude of injury-induced induced MCP-1 production did not differ between wild-type and ICE -/- animals.	Oxygen	89-91	chemokine (C-C motif) ligand 2	Mus musculus	299-304
11339823-3	2001	They released macrophage-derived tumoricidal mediators like NO, O2(-), and ONOO(-) which exhibited potent cytotoxic activity against AK-5 cells in vitro.	Oxygen	64-66	adenylate kinase 5	Mus musculus	133-137
11325277-3	2001	The stereochemical outcome of the IMDAF cycloaddition has the sidearm of the tethered alkenyl group oriented syn with respect to the oxygen bridge.	Oxygen	133-139	synemin	Homo sapiens	109-112
11439121-7	2001	In humans, the homologous XPG protein is also involved in removal of oxygen-damaged nucleotides by base excision repair.	Oxygen	69-75	ERCC excision repair 5, endonuclease	Homo sapiens	26-29
11286986-14	2001	The YC-1 effect may be linked with the metal-related oxygen sensing pathway, and is not due to the stimulation of sGC.	Oxygen	53-59	RNA binding motif single stranded interacting protein 1	Homo sapiens	4-8
11282084-9	2001	A 6 h oxygen deprivation with nitrogen resulted in elevated levels of Hsp60 (media: P=0.048), of Hsp72 (intima: P&lt;0.001 and media: P=0.004) and of Hsp73 (intima: P=0.029) in the saphenous vein.	Oxygen	6-12	heat shock protein family D (Hsp60) member 1	Homo sapiens	70-75
11282084-9	2001	A 6 h oxygen deprivation with nitrogen resulted in elevated levels of Hsp60 (media: P=0.048), of Hsp72 (intima: P&lt;0.001 and media: P=0.004) and of Hsp73 (intima: P=0.029) in the saphenous vein.	Oxygen	6-12	heat shock protein family A (Hsp70) member 8	Homo sapiens	150-155
11295538-1	2001	It has been proposed that myoglobin (Mb), besides being an oxygen carrier, plays the role of a nitric oxide (NO) scavenger in heart and skeletal muscle.	Oxygen	59-65	myoglobin	Mus musculus	26-35
11295538-1	2001	It has been proposed that myoglobin (Mb), besides being an oxygen carrier, plays the role of a nitric oxide (NO) scavenger in heart and skeletal muscle.	Oxygen	59-65	myoglobin	Mus musculus	37-39
11292898-11	2001	Oxygen delivery of terminal cardioplegia was almost four times higher in HS-B group (90.4+/-17.7 vs 18.7+/-1.1 mcl/ml), contrarily, HS-C group showed four times higher oxygen extraction ratio compared to HS-B group (0.78+/-0.06 vs 0.18+/-0.11), thus oxygen consumption during hot shot was maintained at the same level in both groups.	Oxygen	0-6	alcohol dehydrogenase iron containing 1	Homo sapiens	276-279
11230564-1	2001	Brassinosteroids (BRs) are plant steroids essential for normal growth and development and can be defined as steroids that carry an oxygen moiety at C-3 and additional ones at one or more of the C-2, C-6, C-22 and C-23 carbon atoms.	Oxygen	131-137	complement C3	Homo sapiens	148-151
11341946-7	2001	These alterations of the binding activity of IRP-1 in response to oxygen and iron were not reproduced in the cell-free extract.	Oxygen	66-72	aconitase 1	Mus musculus	45-50
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Oxygen	41-47	aconitase 1	Mus musculus	98-103
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Oxygen	189-195	aconitase 1	Mus musculus	98-103
11811779-0	2001	The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose.	Oxygen	137-143	platelet derived growth factor subunit B	Homo sapiens	54-60
11133970-2	2001	Saccharomyces cerevisiae cells derepress expression of OLE1 encoding Delta9 fatty acid desaturase under hypoxic conditions to allow more-efficient use of limited O(2).	Oxygen	162-166	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	55-59
11133970-3	2001	It has been proposed that aerobic conditions lead to repression of OLE1 by well-established O(2)-responsive repressor Rox1p, since putative binding sequences for Rox1p are present in the promoter of OLE1.	Oxygen	92-96	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	67-71
11133970-3	2001	It has been proposed that aerobic conditions lead to repression of OLE1 by well-established O(2)-responsive repressor Rox1p, since putative binding sequences for Rox1p are present in the promoter of OLE1.	Oxygen	92-96	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	199-203
11169614-7	2001	Present results suggest that Fos expression in various brainstem areas was induced by reduced oxygen tension in the ambient air at high altitude.	Oxygen	94-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-32
11770031-12	2001	An inverse relationship was found for IL-10 (IL-6) levels and venous O2 saturation (SvO2), and mean arterial pressure (MAP).	Oxygen	69-71	interleukin 10	Homo sapiens	38-43
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Oxygen	82-88	acetyl-CoA acyltransferase 1	Homo sapiens	24-28
11076611-5	2000	For dioxa cages, the structural facial difference around the reaction center is minor, but the electronic difference of syn and anti faces generated by the two remote oxygen atoms is clearly demonstrated via frontier orbital and MEP analyses.	Oxygen	167-173	synemin	Homo sapiens	120-123
11097175-1	2000	Bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the copper-, ascorbate-, and O2-dependent cleavage of C-terminal glycine-extended peptides, N-acylglycines, and the bile acid glycine conjugates to the corresponding amides and glyoxylate.	Oxygen	104-106	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	13-58
11097175-1	2000	Bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the copper-, ascorbate-, and O2-dependent cleavage of C-terminal glycine-extended peptides, N-acylglycines, and the bile acid glycine conjugates to the corresponding amides and glyoxylate.	Oxygen	104-106	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	60-63
11236678-0	2000	[Effect of hyperbaric oxygen on the expression of proteins Bcl-2 and Bax in the gerbil hippocampus CA1 following forebrain ischemia reperfusion].	Oxygen	22-28	carbonic anhydrase 1	Homo sapiens	99-102
11043580-10	2000	In addition, mRNAs for the helix-loop-helix factors Mash-2 (mammalian achaete-scute homologous protein-2) and Id1 (inhibitor of differentiation 1) were readily detectable in freshly isolated cytotrophoblasts and were markedly decreased upon differentiation to syncytiotrophoblast in 20% O2.	Oxygen	287-289	achaete-scute family bHLH transcription factor 2	Homo sapiens	52-58
11043580-10	2000	In addition, mRNAs for the helix-loop-helix factors Mash-2 (mammalian achaete-scute homologous protein-2) and Id1 (inhibitor of differentiation 1) were readily detectable in freshly isolated cytotrophoblasts and were markedly decreased upon differentiation to syncytiotrophoblast in 20% O2.	Oxygen	287-289	achaete-scute family bHLH transcription factor 2	Homo sapiens	60-104
11043580-17	2000	These findings suggest that Mash-2 may serve as a hypoxia-induced transcription factor that prevents differentiation to syncytiotrophoblast and aromatase induction in human trophoblast cultured under low O2 conditions.	Oxygen	204-206	achaete-scute family bHLH transcription factor 2	Homo sapiens	28-34
11027709-8	2000	Experiments with ruthenium red, which is a blocker of Ca(2+) fluxes in rice as well as maize (Zea mays), suggest that the induction of expression of Adh1 and Pdc1 by low oxygen stress is regulated by elevation of the cytosolic Ca(2+) level.	Oxygen	170-176	pyruvate decarboxylase 1	Zea mays	158-162
11015726-7	2000	In particular, control mechanisms that underpin the oxygen-mediated regulation of ATF1 gene transcription appear to be closely linked to those involved in the regulation of fatty acid metabolism.	Oxygen	52-58	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	82-86
11006124-5	2000	Elevated mRNA and protein levels were first observed in cells cultured in 1% oxygen for 8 h. Although PROXY-1 mRNA levels returned to near-control values within 2 h of reexposure to 20% oxygen, protein levels remained high 72 h after reexposure to 20% oxygen.	Oxygen	77-83	N-myc downstream regulated 1	Homo sapiens	102-109
11006124-5	2000	Elevated mRNA and protein levels were first observed in cells cultured in 1% oxygen for 8 h. Although PROXY-1 mRNA levels returned to near-control values within 2 h of reexposure to 20% oxygen, protein levels remained high 72 h after reexposure to 20% oxygen.	Oxygen	186-192	N-myc downstream regulated 1	Homo sapiens	102-109
11006124-5	2000	Elevated mRNA and protein levels were first observed in cells cultured in 1% oxygen for 8 h. Although PROXY-1 mRNA levels returned to near-control values within 2 h of reexposure to 20% oxygen, protein levels remained high 72 h after reexposure to 20% oxygen.	Oxygen	186-192	N-myc downstream regulated 1	Homo sapiens	102-109
10947958-0	2000	Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures.	Oxygen	14-20	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	57-62
10947958-6	2000	Oxygen-dependent modulation of mdr1b mRNA expression was prevented by actinomycin D, indicating transcriptional regulation.	Oxygen	0-6	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	31-36
10947958-7	2000	Inhibition of haem synthesis by 25 microM CoCl(2) blocked mdr1b mRNA expression under both oxygen tensions, whereas 80 microM desferrioxamine abolished modulation by O(2).	Oxygen	91-97	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	58-63
10947958-10	2000	These results support the conclusion that haem proteins are crucial for modulation of mdr1b mRNA expression by O(2) in hepatocyte cultures and that reactive oxygen species may participate in O(2)-dependent signal transduction.	Oxygen	111-115	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	86-91
10947958-11	2000	Furthermore, the present study suggests that oxygen might be a critical modulator for zonated secretion of mdr1 substrates into the bile.	Oxygen	45-51	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	107-111
10930551-4	2000	We found that cystatin C and HuC mRNA, the products of which are an inhibitor of cysteine proteases and an RNA binding protein, respectively, were up-regulated in neurons cultured in the high oxygen atmosphere.	Oxygen	192-198	ELAV like RNA binding protein 3	Rattus norvegicus	29-32
10946986-10	2000	The increased ECD was perhaps related to the daily wear schedule in which the oxygen partial pressure was sufficient.	Oxygen	78-84	ecdysoneless cell cycle regulator	Homo sapiens	14-17
10877840-3	2000	Lipoxygenases are enzymes that, as cyclooxygenases (COX), can insert oxygen into the molecule of arachidonic acid and thereby synthesize inflammatory eicosanoids: leukotrienes [due to 5-lipoxygenase (5-LOX) activity] and prostaglandins (via COX activity).	Oxygen	3-9	lysyl oxidase	Homo sapiens	202-205
10940194-10	2000	Expression of one of them is induced in trophoblast and other cell types cultured under low oxygen levels and the product of the gene is a 43-kDa protein which we have termed PROXY-1.	Oxygen	92-98	N-myc downstream regulated 1	Homo sapiens	175-182
10748104-1	2000	In Chlamydomonas reinhardtii mutants deficient in photosystem I because of inactivation of the chloroplast genes psaA or psaB, oxygen evolution from photosystem II occurs at significant rates and is coupled to a stimulation of oxygen uptake.	Oxygen	127-133	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	121-125
10748104-1	2000	In Chlamydomonas reinhardtii mutants deficient in photosystem I because of inactivation of the chloroplast genes psaA or psaB, oxygen evolution from photosystem II occurs at significant rates and is coupled to a stimulation of oxygen uptake.	Oxygen	227-233	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	121-125
10810708-0	2000	Unexpected products via singlet oxygen oxygenation of functionalized 5,6-dihydro-1,4-oxathiins [formula: see text] Single oxygen oxygenation of 5,6-dihydro-1,4-oxathiins substituted at C-3 with an electron-withdrawing group leads stereoselectively to ketosulfoxides 5 and 6, instead of the expected dicarbonyl compounds 3.	Oxygen	32-38	complement C3	Homo sapiens	185-188
10790164-4	2000	Nitroglycerine-induced relaxation was associated with a reduction in O2 consumption, suggesting that the interaction between phosphorylated myosin and the thin filament was inhibited.	Oxygen	69-71	myosin X	Sus scrofa	140-146
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Oxygen	204-211	synemin	Homo sapiens	136-139
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Oxygen	204-211	synemin	Homo sapiens	241-244
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Oxygen	204-210	synemin	Homo sapiens	136-139
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Oxygen	204-210	synemin	Homo sapiens	241-244
10763960-10	2000	In patients with positive KDR in the tumor, the arterial levels of PO2 and O2 saturation were significantly lower than those in patients without its expression.	Oxygen	68-70	kinase insert domain receptor	Homo sapiens	26-29
10816041-9	2000	This "oxidant-induced reduction" of cytochrome b suggests that electron transport from sulfide to oxygen in A. aeolicus employs the cytochrome bc complex via the quinone pool.	Oxygen	98-104	petB	Aquifex aeolicus VF5	36-48
10727416-6	2000	Only a modest increase in intracellular oxygen species was found in thymocytes stimulated by strong cross-linking of TCR together with CD4 or CD28.	Oxygen	40-46	CD4 antigen	Mus musculus	135-138
10798523-5	2000	Conformational searches located some low energy conformations that contained relatively short oxygen to carbonyl carbon distances, which indicated that the oxazole forming fragment in microcin B17 is preorganized for cyclization.	Oxygen	94-100	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	193-196
10700391-13	2000	The kinetic analysis of redox changes in lysosomes revealed that electron carriers operate in the sequence NADH &gt; FAD &gt; cytochrome b &gt; ubiquinone &gt; oxygen.	Oxygen	160-166	cytochrome b, mitochondrial	Rattus norvegicus	126-138
10714522-6	2000	RESULTS: In each breed, partial pressure of oxygen at 50% saturation of hemoglobin (P50) under standard conditions was significantly higher in older than in neonatal calves, indicating a right shift in OEC with age.	Oxygen	44-50	secernin 1	Bos taurus	84-87
11017610-0	2000	Origin of O 1s core-level shifts on oxygen adsorbed Si(111)-(7x7) Density functional calculations are used to examine the chemical and structural origin of O 1s core-level shifts measured on the initial oxidation stage of Si(111)-(7x7).	Oxygen	36-42	immunoglobulin kappa variable 2D-40	Homo sapiens	10-13
10674475-6	2000	Severe hypoxia, where cytochrome oxidase was reduced, caused a significant induction of c-fos mRNA At this stage, the oxygen concentration in cerebral tissue fell to &lt; 10(-7) M. These data suggest that the decline in oxidative phosphorylation might be a trigger for the induction of c-fos mRNA.	Oxygen	118-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93
10666155-10	2000	It appears that ADM and ADM-R belong to the family of classic oxygen-regulated genes, which are activated by a decrease of the pericellular oxygen tension through the same intracellular signaling cascade.	Oxygen	62-68	adrenomedullin	Rattus norvegicus	16-19
10666155-10	2000	It appears that ADM and ADM-R belong to the family of classic oxygen-regulated genes, which are activated by a decrease of the pericellular oxygen tension through the same intracellular signaling cascade.	Oxygen	62-68	adrenomedullin	Rattus norvegicus	24-27
10666155-10	2000	It appears that ADM and ADM-R belong to the family of classic oxygen-regulated genes, which are activated by a decrease of the pericellular oxygen tension through the same intracellular signaling cascade.	Oxygen	140-146	adrenomedullin	Rattus norvegicus	16-19
10666155-10	2000	It appears that ADM and ADM-R belong to the family of classic oxygen-regulated genes, which are activated by a decrease of the pericellular oxygen tension through the same intracellular signaling cascade.	Oxygen	140-146	adrenomedullin	Rattus norvegicus	24-27
10666398-7	2000	PTK787, a drug that blocks phosphorylation by VEGF and PDGF receptors, but not PKC, completely inhibited retinal NV in murine oxygen-induced ischemic retinopathy and partially inhibited retinal vascularization during development.	Oxygen	126-132	vascular endothelial growth factor A	Mus musculus	46-50
10676651-0	2000	Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen-free radicals in tumor tissue.	Oxygen	84-90	xanthine dehydrogenase	Mus musculus	34-50
10813959-2	2000	Interaction between the silicon in the trialkylsilyl group and the carbonyl oxygen in nucleophiles was postulated to stabilize the transition state, leading preferably to the syn diastereisomers.	Oxygen	76-82	synemin	Homo sapiens	175-178
11191053-6	2000	At low O2 tension, the stabilized and nuclear hypoxia inducible factor- 1alpha (HIF-1alpha) is directly phosphorylated by p42/p44 MAPKs, an action which enhances HIF-1-dependent transcriptional activition of VEGF.	Oxygen	7-9	vascular endothelial growth factor A	Mus musculus	208-212
10705990-12	1999	This change in oxygen consumption and H2O2 production is enhanced by NADPH.	Oxygen	15-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	69-74
10670793-11	1999	An inverse relationship could be seen between IL-10 plasma levels and venous O2 saturation: low values for O2 saturation correlated with high IL-10 levels as did low mean arterial pressure (MAP).	Oxygen	77-79	interleukin 10	Homo sapiens	46-51
10670793-11	1999	An inverse relationship could be seen between IL-10 plasma levels and venous O2 saturation: low values for O2 saturation correlated with high IL-10 levels as did low mean arterial pressure (MAP).	Oxygen	107-109	interleukin 10	Homo sapiens	46-51
10670793-11	1999	An inverse relationship could be seen between IL-10 plasma levels and venous O2 saturation: low values for O2 saturation correlated with high IL-10 levels as did low mean arterial pressure (MAP).	Oxygen	107-109	interleukin 10	Homo sapiens	142-147
10670793-15	1999	Low values for venous O2 saturation and low MAP correlated with high IL-10 levels.	Oxygen	22-24	interleukin 10	Homo sapiens	69-74
10563822-7	1999	We propose that the transition from the high-spin to the low-spin form of the protein occurs by deprotonation and ligation to the heme of the B10 tyrosine oxygen, facilitated by strong interaction with the E10 lysine side chain.	Oxygen	155-161	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	142-145
10565290-1	1999	The response of first-generation glucose oxidase (GOx) amperometric glucose biosensors is strongly dependent on the concentration of the oxygen cosubstrate.	Oxygen	137-143	hydroxyacid oxidase 1	Homo sapiens	33-48
10565290-1	1999	The response of first-generation glucose oxidase (GOx) amperometric glucose biosensors is strongly dependent on the concentration of the oxygen cosubstrate.	Oxygen	137-143	hydroxyacid oxidase 1	Homo sapiens	50-53
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	33-39	hydroxyacid oxidase 1	Homo sapiens	64-67
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	123-129	hydroxyacid oxidase 1	Homo sapiens	64-67
10565290-2	1999	The incorporation of the natural oxygen binder myoglobin into a GOx-containing carbon-paste matrix is shown to satisfy the oxygen demand of the enzymatic reaction and to provide convenient biosensing of glucose in oxygen-free solutions.	Oxygen	123-129	hydroxyacid oxidase 1	Homo sapiens	64-67
10876842-2	1999	Both SEA and LPS, when injected to animals, produced stimulating influence on the oxygen metabolism of phagocytizing cells.	Oxygen	82-88	sepia	Mus musculus	5-8
10876842-4	1999	Under the conditions of the development of lethal toxic shock, i.e. after the combined injection of SEA and LPS, the synergic activation of oxygen metabolism was observed, which was also manifested by the pronounced production of TNF alpha and the increased synthesis of gamma-interferon.	Oxygen	140-146	sepia	Mus musculus	100-103
10526246-12	1999	Maximal oxygen uptake (VO(2)max) per kg body weight (BW) (litres/min per kg) correlated significantly with the amount of MHC I (r=0.60) and MHC IIX (r=-0.72) but not with the amount of MHC IIA (r=0.35).	Oxygen	8-14	major histocompatibility complex, class I, C	Homo sapiens	121-124
10526246-12	1999	Maximal oxygen uptake (VO(2)max) per kg body weight (BW) (litres/min per kg) correlated significantly with the amount of MHC I (r=0.60) and MHC IIX (r=-0.72) but not with the amount of MHC IIA (r=0.35).	Oxygen	8-14	major histocompatibility complex, class I, C	Homo sapiens	140-143
10526246-12	1999	Maximal oxygen uptake (VO(2)max) per kg body weight (BW) (litres/min per kg) correlated significantly with the amount of MHC I (r=0.60) and MHC IIX (r=-0.72) but not with the amount of MHC IIA (r=0.35).	Oxygen	8-14	major histocompatibility complex, class I, C	Homo sapiens	140-143
10549609-7	1999	CONCLUSIONS: The role of reactive oxygen intermediates in signal transduction pathways leading to ICAM-1 expression should be investigated further.	Oxygen	34-40	intercellular adhesion molecule 1	Homo sapiens	98-104
10468637-1	1999	Myoglobin may serve a variety of functions in muscular oxygen supply, such as O(2) storage, facilitated O(2) diffusion, and myoglobin-mediated oxidative phosphorylation.	Oxygen	55-61	myoglobin	Mus musculus	0-9
10468637-1	1999	Myoglobin may serve a variety of functions in muscular oxygen supply, such as O(2) storage, facilitated O(2) diffusion, and myoglobin-mediated oxidative phosphorylation.	Oxygen	78-82	myoglobin	Mus musculus	0-9
10468637-1	1999	Myoglobin may serve a variety of functions in muscular oxygen supply, such as O(2) storage, facilitated O(2) diffusion, and myoglobin-mediated oxidative phosphorylation.	Oxygen	104-108	myoglobin	Mus musculus	0-9
10468637-12	1999	These data demonstrate that disruption of myoglobin results in the activation of multiple compensatory mechanisms that steepen the pO(2) gradient and reduce the diffusion path length for O(2) between capillary and the mitochondria; this suggests that myoglobin normally is important for the delivery of oxygen.	Oxygen	132-136	myoglobin	Mus musculus	42-51
10468637-12	1999	These data demonstrate that disruption of myoglobin results in the activation of multiple compensatory mechanisms that steepen the pO(2) gradient and reduce the diffusion path length for O(2) between capillary and the mitochondria; this suggests that myoglobin normally is important for the delivery of oxygen.	Oxygen	132-136	myoglobin	Mus musculus	251-260
10468637-12	1999	These data demonstrate that disruption of myoglobin results in the activation of multiple compensatory mechanisms that steepen the pO(2) gradient and reduce the diffusion path length for O(2) between capillary and the mitochondria; this suggests that myoglobin normally is important for the delivery of oxygen.	Oxygen	303-309	myoglobin	Mus musculus	42-51
10468637-12	1999	These data demonstrate that disruption of myoglobin results in the activation of multiple compensatory mechanisms that steepen the pO(2) gradient and reduce the diffusion path length for O(2) between capillary and the mitochondria; this suggests that myoglobin normally is important for the delivery of oxygen.	Oxygen	303-309	myoglobin	Mus musculus	251-260
10574379-1	1999	Cytochrome b558 is part of the NADPH oxidase complex of phagocytes, but it has also been proposed to function as a cellular oxygen sensor, e.g. in the carotid body.	Oxygen	124-130	cytochrome b, mitochondrial	Rattus norvegicus	0-12
10438466-1	1999	An activation domain in p67(phox) (residues within 199-210) is essential for cytochrome b(558)-dependent activation of NADPH superoxide (O2(-.))	Oxygen	137-139	mitochondrially encoded cytochrome b	Homo sapiens	77-89
28871643-9	1999	RESULTS: Nasal CPAP, when applied to preterm infants being extubated following IPPV, reduces the incidence of adverse clinical events (apnoea, respiratory acidosis and increased oxygen requirements) indicating the need for additional ventilatory support.	Oxygen	178-184	centromere protein J	Homo sapiens	15-19
10478487-6	1999	3"-OMe-dC was a superior inhibitor of dCK to its 5"-O-methyl congener, consistent with possible participation of the oxygen of the (3")-OH or (3")-OMe as proton acceptor in hydrogen bonding with the enzyme.	Oxygen	117-123	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	38-41
11783229-5	1999	CONCLUSION: AS could improve the effect of heart preservation of mEC solution, its mechanism might be associated with the effect of negative contractile strength and preventing oxygen free radical injury.	Oxygen	177-183	chemokine (C-C motif) ligand 28	Mus musculus	65-68
10419036-2	1999	Reactive oxygen metabolites (ROMs) produced also physiologically in the body, are normally neutralised by antioxidative enzymes such as superoxide dismutase (SOD).	Oxygen	9-15	AT695_RS09750	Staphylococcus aureus	136-156
10419036-2	1999	Reactive oxygen metabolites (ROMs) produced also physiologically in the body, are normally neutralised by antioxidative enzymes such as superoxide dismutase (SOD).	Oxygen	9-15	AT695_RS09750	Staphylococcus aureus	158-161
10424559-0	1999	Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.	Oxygen	77-83	interleukin 11	Mus musculus	28-42
10398710-0	1999	Periplasmic carbonic anhydrase structural gene (Cah1) mutant in chlamydomonas reinhardtii To survive in various conditions of CO2 availability, Chlamydomonas reinhardtii shows adaptive changes, such as induction of a CO2-concentrating mechanism, changes in cell organization, and induction of several genes, including a periplasmic carbonic anhydrase (pCA1) encoded by Cah1. Among a collection of insertionally generated mutants, a mutant has been isolated that showed no pCA1 protein and no Cah1 mRNA.	Oxygen	127-130	uncharacterized protein	Chlamydomonas reinhardtii	48-52
10329706-13	1999	The signaling cascade preceding Elk-1 activation in response to oxygen deprivation was traced to activation of protein kinase C-betaII, Raf, mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase and mitogen-activated protein kinases.	Oxygen	64-70	ETS transcription factor ELK1	Homo sapiens	32-37
10092521-1	1999	The large subunit of cytochrome b558, gp91-phox, is believed to play a key role in superoxide generation in neutrophils by accepting electrons from NADPH and donating them to molecular oxygen.	Oxygen	185-191	mitochondrially encoded cytochrome b	Homo sapiens	21-33
10092521-1	1999	The large subunit of cytochrome b558, gp91-phox, is believed to play a key role in superoxide generation in neutrophils by accepting electrons from NADPH and donating them to molecular oxygen.	Oxygen	185-191	cytochrome b-245 beta chain	Homo sapiens	38-47
10225612-1	1999	The purpose of the present work was to verify the effect of pyridostigmine bromide, a reversible cholinesterase inhibitor, on the increases in cardiac work and myocardial oxygen demand produced by central sympathetic stimulation in pentobarbital-anesthetized Wistar rats.	Oxygen	171-177	butyrylcholinesterase	Rattus norvegicus	97-111
10225612-5	1999	In conclusion, the increases in endogenous acetylcholine induced by cholinesterase inhibition blunted the centrally-evoked increases in myocardial oxygen demand in anesthetized rats.	Oxygen	147-153	butyrylcholinesterase	Rattus norvegicus	68-82
10214958-1	1999	Changes in extensin gene expression were examined in cultured tomato cells following treatments leading to the production of activated oxygen species.	Oxygen	135-141	extensin-3-like	Solanum lycopersicum	11-19
10214958-5	1999	Furthermore, cells treated with enzymatically produced O2-* generated by xanthine oxidase (0.015 U/ml) gave a similar extensin response and again, SOD exerted a strong inhibitory effect on the response.	Oxygen	55-57	extensin-3-like	Solanum lycopersicum	118-126
10066743-10	1999	These results are consistent with at least two hydrogen bonds stabilizing the bound oxygen molecule, one from tyrosine B10 and the other from the distal glutamine.	Oxygen	84-90	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	119-122
10416679-1	1999	Manganese superoxide dismutase (Mn-SOD) is a naturally-occurring scavenger of superoxide, one of several reactive oxygen intermediates.	Oxygen	114-120	superoxide dismutase 2	Rattus norvegicus	0-30
10416679-1	1999	Manganese superoxide dismutase (Mn-SOD) is a naturally-occurring scavenger of superoxide, one of several reactive oxygen intermediates.	Oxygen	114-120	superoxide dismutase 2	Rattus norvegicus	32-38
10698572-1	1999	This work presents an amperometric biosensor incorporated into a flow configuration comprising salicylate hydroxylase that catalyses the irreversible hydroxylation of salicylate to catechol in the presence of NADH and molecular oxygen, and tyrosinase that further oxidises catechol giving o-quinone which is electrochemically reduced at -100 mV vs. Ag/AgCl yielding catechol and entering the catalytic oxidation and electrochemical reduction cycling which results in signal amplification and, consequently, low limits of detection.	Oxygen	228-234	tyrosinase	Homo sapiens	240-250
10190572-16	1999	These results showed that N,N"-substituted alkylthioureas were capable of inducing mEH and rGSTA2 in the liver with elevation of the mRNAs, that induction of mEH and rGSTA2 by these alkylthioureas might be mediated by production of the reactive oxygens derived from metabolic activation of the agents irrespective of their radical scavenging effect and that the agents rather enhanced toxicant-induced liver injury with the induction of P450 2E1 or P450 2B1/2.	Oxygen	245-252	glutathione S-transferase alpha 2	Rattus norvegicus	91-97
10190572-16	1999	These results showed that N,N"-substituted alkylthioureas were capable of inducing mEH and rGSTA2 in the liver with elevation of the mRNAs, that induction of mEH and rGSTA2 by these alkylthioureas might be mediated by production of the reactive oxygens derived from metabolic activation of the agents irrespective of their radical scavenging effect and that the agents rather enhanced toxicant-induced liver injury with the induction of P450 2E1 or P450 2B1/2.	Oxygen	245-252	glutathione S-transferase alpha 2	Rattus norvegicus	166-172
10217667-10	1999	High ICAM-1 levels and low TGF beta 1 levels in lung fluid are related to oxygen dependency at 28 days of age.	Oxygen	74-80	intercellular adhesion molecule 1	Homo sapiens	5-11
9930922-12	1999	In a different experimental setup a saturated carbon monoxide solution in the absence of ambient oxygen or NO stimulated the enzyme 15-fold in the absence and 1260-fold in the presence of YC-1 compared to an argon control.	Oxygen	97-103	glutathione S-transferase alpha 1	Rattus norvegicus	188-192
12115012-1	1999	It was demonstrated by oxygen equilibrium curve that the pyridoxal 5-phosphate(PLP) modified porcine deoxyhemoglobin(pHbbeta) had lower oxygen affinity than that of stroma-free porcine hemoglobin(pHb).	Oxygen	23-29	proteolipid protein 1	Homo sapiens	79-82
12115012-1	1999	It was demonstrated by oxygen equilibrium curve that the pyridoxal 5-phosphate(PLP) modified porcine deoxyhemoglobin(pHbbeta) had lower oxygen affinity than that of stroma-free porcine hemoglobin(pHb).	Oxygen	136-142	proteolipid protein 1	Homo sapiens	79-82
9894151-4	1998	The decreased O2- production seen with calyculin A pretreatment followed by PMA may be due to diminished translocation of the p47-phox and p67-phox, cytosolic components of the oxidase, and inhibition of arachidonic acid release.	Oxygen	14-16	neutrophil cytosolic factor 1	Homo sapiens	126-134
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	46-48	H4 clustered histone 4	Homo sapiens	274-277
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	H4 clustered histone 4	Homo sapiens	117-120
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	H4 clustered histone 4	Homo sapiens	274-277
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	H4 clustered histone 4	Homo sapiens	117-120
9918817-5	1998	Thus, we deduce that (1) L-Arg stabilizes the O2-bound ferrous complex for efficient O-O bond cleavage to occur; (2) H4B influences the O2-bound ferrous complex in a fashion different from L-Arg; and (3) NHA induces a characteristic distal-site structure in the presence of H4B, reflecting a difference in the mechanism of activation of O2 in the first step (monooxygenation of L-Arg) and the second step (monooxygenation of NHA).	Oxygen	136-138	H4 clustered histone 4	Homo sapiens	274-277
9852050-6	1998	When the oxygen concentration in the system was decreased, the rate of O-2 production and cytochrome c reduction by antimycin-treated reductase decreased.	Oxygen	9-15	immunoglobulin kappa variable 1D-39	Homo sapiens	71-74
9852050-9	1998	These results indicate that generation of O-2 during the oxidation of ubiquinol by the cytochrome bc1 complex results from a leakage of the second electron of ubiquinol from its Q cycle electron transfer pathway to interact with oxygen.	Oxygen	229-235	immunoglobulin kappa variable 1D-39	Homo sapiens	42-45
9852050-13	1998	These results suggest that reduced FAD of succinate dehydrogenase is the electron donor for oxygen to produce O-2 in the absence of their immediate electron acceptor and in the presence of cytochrome c.	Oxygen	92-98	immunoglobulin kappa variable 1D-39	Homo sapiens	110-113
9826612-3	1998	For avidin-bound N-biotinyl phosphatidylethanolamine spin-labeled on the 8 C atom of the sn-2 chain, the relaxation enhancement induced by 30 mM Ni2+ ions confined to the aqueous phase was 2.5 times that induced by saturating molecular oxygen, which is preferentially concentrated in the hydrophobic core of the membrane.	Oxygen	236-242	spindlin 1	Homo sapiens	53-57
9826612-4	1998	For phosphatidylcholine also spin-labeled at the 8 position of the sn-2 chain, this ratio was reversed: the relaxation enhancement by Ni2+ ions was half that induced by molecular oxygen.	Oxygen	179-185	spindlin 1	Homo sapiens	29-33
9870556-6	1998	3HAO requires dioxygen as a substrate but it was inactivated approximately 40% by 5.2 atm HBO in vitro in 15 min.	Oxygen	14-22	3-hydroxyanthranilate 3,4-dioxygenase	Rattus norvegicus	0-4
9894911-1	1998	Transcriptional regulation of the yeast cytochrome c1 gene (CYT1) in response to oxygen and carbon source is mediated by Haplp and the Hap2 complex.	Oxygen	81-87	ubiquinol--cytochrome-c reductase catalytic subunit CYT1	Saccharomyces cerevisiae S288C	60-64
9866692-8	1998	Compared to other methods currently employed to measure PSI activity such as oxygen uptake in the presence of methyl viologen and NADP+ photoreduction in the presence of ferredoxin and ferredoxin:NADP+ oxidoreductase, measurement of PSI activity with flavodoxin as an electron acceptor has several advantages.	Oxygen	77-83	oxidoreductase	Escherichia coli	202-216
9806742-2	1998	Because the cyclin-dependent kinase inhibitor p21(Cip1/WAF1) (p21) inhibits cell proliferation in G1/S, enhances DNA repair, and regulates apoptosis in some cells, we hypothesized that the expression of p21 would increase in lungs of C57Bl/6J male mice exposed to and recovered from &gt; 95% oxygen.	Oxygen	292-298	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	46-49
9806742-2	1998	Because the cyclin-dependent kinase inhibitor p21(Cip1/WAF1) (p21) inhibits cell proliferation in G1/S, enhances DNA repair, and regulates apoptosis in some cells, we hypothesized that the expression of p21 would increase in lungs of C57Bl/6J male mice exposed to and recovered from &gt; 95% oxygen.	Oxygen	292-298	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	50-54
9806742-2	1998	Because the cyclin-dependent kinase inhibitor p21(Cip1/WAF1) (p21) inhibits cell proliferation in G1/S, enhances DNA repair, and regulates apoptosis in some cells, we hypothesized that the expression of p21 would increase in lungs of C57Bl/6J male mice exposed to and recovered from &gt; 95% oxygen.	Oxygen	292-298	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	55-59
9806742-2	1998	Because the cyclin-dependent kinase inhibitor p21(Cip1/WAF1) (p21) inhibits cell proliferation in G1/S, enhances DNA repair, and regulates apoptosis in some cells, we hypothesized that the expression of p21 would increase in lungs of C57Bl/6J male mice exposed to and recovered from &gt; 95% oxygen.	Oxygen	292-298	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	62-65
9806742-2	1998	Because the cyclin-dependent kinase inhibitor p21(Cip1/WAF1) (p21) inhibits cell proliferation in G1/S, enhances DNA repair, and regulates apoptosis in some cells, we hypothesized that the expression of p21 would increase in lungs of C57Bl/6J male mice exposed to and recovered from &gt; 95% oxygen.	Oxygen	292-298	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	62-65
9760253-2	1998	Bovine lens aldose reductase (ALR2) is inactivated by copper ion [Cu(II)] through an oxygen-independent oxidative modification process.	Oxygen	85-91	aldose reductase	Bos taurus	12-28
9722559-2	1998	Fet3p is proposed to facilitate iron uptake by catalyzing the oxidation of Fe(II) to Fe(III) by O2; in this model, Fe(III) is the substrate for the iron permease, encoded by FTR1.	Oxygen	96-98	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	174-178
9854632-2	1998	Morphine and adrenaline caused different changes in production of active forms of oxygen (AFA) and antioxidant activity of the enzymes superoxide dismutase and glutathione reductase in neutrophils, monocytes, and lymphocytes in human peripheral blood.	Oxygen	82-88	AFA	Homo sapiens	90-93
9728926-2	1998	Because these patients" red blood cells (RBCs) contain mainly two Hb species, HbH and HbA, the high proportion of HbA can be exploited by lowering its oxygen affinity; this would probably increase oxygen delivery to the RBCs and improve the patients" clinical phenotype.	Oxygen	151-157	keratin 90, pseudogene	Homo sapiens	86-89
9728926-2	1998	Because these patients" red blood cells (RBCs) contain mainly two Hb species, HbH and HbA, the high proportion of HbA can be exploited by lowering its oxygen affinity; this would probably increase oxygen delivery to the RBCs and improve the patients" clinical phenotype.	Oxygen	151-157	keratin 90, pseudogene	Homo sapiens	114-117
9728926-2	1998	Because these patients" red blood cells (RBCs) contain mainly two Hb species, HbH and HbA, the high proportion of HbA can be exploited by lowering its oxygen affinity; this would probably increase oxygen delivery to the RBCs and improve the patients" clinical phenotype.	Oxygen	197-203	keratin 90, pseudogene	Homo sapiens	114-117
9728926-4	1998	We investigated the effect of a bezafibrate derivative, RSR-4, on the oxygen affinity of RBCs and purified hemolysates containing HbA and HbH.	Oxygen	70-76	keratin 90, pseudogene	Homo sapiens	130-133
9728926-14	1998	Our findings provide an experimental model for lowering the oxygen affinity of HbA in HbH-containing cells and suggest that the oxygen delivery capability of the latter would be thereby improved.	Oxygen	60-66	keratin 90, pseudogene	Homo sapiens	79-82
9728926-14	1998	Our findings provide an experimental model for lowering the oxygen affinity of HbA in HbH-containing cells and suggest that the oxygen delivery capability of the latter would be thereby improved.	Oxygen	128-134	keratin 90, pseudogene	Homo sapiens	79-82
9758895-3	1998	Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils.	Oxygen	65-71	C-C motif chemokine ligand 5	Homo sapiens	47-53
9766702-6	1998	Oxygen uptake at the AT, RCP, P1 and P2 decreased in magnitude first in the active normal subjects, then in sedentary normal subjects and finally in the heart failure patients.	Oxygen	0-6	crystallin gamma F, pseudogene	Homo sapiens	30-39
9712892-1	1998	In the absence of L-arginine, the heme center of the oxygenase domain of neuronal nitric-oxide synthase reduces molecular oxygen to superoxide (O-2).	Oxygen	53-59	immunoglobulin kappa variable 1D-39	Homo sapiens	144-147
9744525-1	1998	Transient transfection studies of human HepG2 and mouse Hepa hepatocarcinoma cells with a reporter gene construct regulated by a human antioxidant responsive element (ARE) from the NQO1 gene demonstrated that the element is responsive to low oxygen conditions.	Oxygen	242-248	NAD(P)H dehydrogenase, quinone 1	Mus musculus	181-185
9663337-1	1998	An engineering model was designed to evaluate oxygen transfer rates for LEH and other oxygen carriers under wall shear rates from 150 sec-1 to 450 sec-1.	Oxygen	46-52	secretory blood group 1, pseudogene	Homo sapiens	134-152
18314552-7	1998	The age-1 mutant was more resistant to, but mev-1 was more sensitive to, such oxygen enhancements of aging than was wild type.	Oxygen	78-84	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	4-9
10375776-9	1998	(3) The bond order of carbon-oxygen bond (C11-O10) was invariant across the series of the compounds.	Oxygen	29-35	RNA polymerase III subunit K	Homo sapiens	42-45
9576845-1	1998	In order to elucidate the components of the oxygen sensory complex in HepG2 cells which regulates the production of erythropoietin, we have microinjected recombinant variants of the human small GTP-binding protein hRac1 and measured their effects on the production of reactive oxygen species (ROS) by the dihydrorhodamine-123 technique.	Oxygen	44-50	Rac family small GTPase 1	Homo sapiens	214-219
9581140-10	1998	Ventilation with 100% oxygen further increased arterial and mixed venous PO2 but did not affect PCO2, when compared with room air ventilation.	Oxygen	22-28	PO2	Sus scrofa	73-76
9545283-1	1998	The leukocyte NADPH oxidase is an enzyme in phagocytes and B lymphocytes that when activated catalyzes the production of O-2 from oxygen and NADPH.	Oxygen	130-136	immunoglobulin kappa variable 1D-39	Homo sapiens	121-124
9536039-4	1998	By contrast, low-oxygen stress caused rapid reduction of polymerized actin coincident with acute inhibition of protein synthesis.	Oxygen	18-24	actin-66	Solanum tuberosum	70-75
9516467-12	1998	The data suggest a model in which dioxygen directly or indirectly modulates the Fe(III)/Fe(II) ratio in an iron pool linked to Aft1 protein while bipyridyl increases this ratio by chelating Fe(II).	Oxygen	34-42	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	127-131
9516467-13	1998	These results indicate that dioxygen both modulates the sensitivity to iron-dependent transcriptional regulation and acts as substrate for Fet3 in the ferroxidase reaction catalyzed by this ceruloplasmin homologue.	Oxygen	28-36	ferroxidase	Saccharomyces cerevisiae S288C	151-162
9515919-3	1998	In addition to FnrL, several other factors, including the two-component Prr regulatory system and the transcriptional repressor PpsR, are known to mediate oxygen control of photosynthesis gene expression in this organism.	Oxygen	155-161	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	15-19
9879512-0	1998	Effect of the locus of the oxygen atom in amino ethers on the inactivation of monoamine oxidase B.	Oxygen	27-33	monoamine oxidase B	Homo sapiens	78-97
9879512-5	1998	The analogues in which the oxygen atom is closest to the alpha-carbon (9 and 10) inactivate MAO B, but activity slowly returns with time.	Oxygen	27-33	monoamine oxidase B	Homo sapiens	92-97
9512648-5	1998	The in vitro exposure of the aortic CEH to active oxygen (AO) generators revealed the PKC-mediated activation of CEH, which was inhibited by superoxide dismutase and catalase.	Oxygen	50-56	epoxide hydrolase 2	Rattus norvegicus	36-39
9512648-5	1998	The in vitro exposure of the aortic CEH to active oxygen (AO) generators revealed the PKC-mediated activation of CEH, which was inhibited by superoxide dismutase and catalase.	Oxygen	50-56	epoxide hydrolase 2	Rattus norvegicus	113-116
9510453-3	1998	The abdominal circumference and gastric air and aspirate volumes were measured prior to meals at trial entry and after 6 h. Discontinuation of CPAP led to a small but significant decrease in oxygenation at 1 and 6 h. During the trial, five infants in the experimental group required supplemental oxygen and one infant was put back on CPAP owing to excessive apnoeas.	Oxygen	191-197	centromere protein J	Homo sapiens	143-147
9458719-4	1998	Cytochrome spectra in NO-treated submitochondrial particles showed a double inhibition of electron transfer at cytochrome oxidase and between cytochrome b and cytochrome c, which accounts for the effects in O2 uptake and H2O2 release.	Oxygen	207-209	cytochrome b, mitochondrial	Rattus norvegicus	142-154
9435065-1	1998	In Pichia stipitis, fermentative and pyruvate decarboxylase (PDC) activities increase with diminished oxygen rather than in response to fermentable sugars.	Oxygen	102-108	PDC1	Scheffersomyces stipitis CBS 6054	37-59
9663452-9	1998	Interestingly, low doses of GLP-1 (1 microg) in lean Zucker rats, which had minimal effects on food intake, caused a 19 +/- 7% increase in O2 consumption during the first 2 h of the nocturnal cycle.	Oxygen	139-141	glucagon	Rattus norvegicus	28-33
9492980-1	1997	Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural intestinal inflammation in Crohn"s disease.	Oxygen	235-241	negative elongation factor complex member C/D	Homo sapiens	107-110
9395278-4	1997	The activation of this receptor by elastin peptides triggers several cellular reactions of biological interest as shown previously such as chemotactic movement to an elastin peptide gradient, modulation of the biosynthesis of connective tissue macromolecules, increase of protease synthesis and release of free radicals (O2-., NO.)	Oxygen	321-323	elastin	Homo sapiens	35-42
9603288-1	1997	We investigated the distribution and regulation of the optic nerve head (ONH) tissue partial pressure of oxygen (PO2) under various stimuli and the role of the nitric oxide in the ONH circulation.	Oxygen	105-111	PO2	Sus scrofa	113-116
9342391-5	1997	AHB1 is induced, in both roots and rosette leaves, by low oxygen levels.	Oxygen	58-64	hemoglobin 1	Arabidopsis thaliana	0-4
9342391-6	1997	Recombinant AHB1 has an oxygen affinity so high as to make it unlikely to function as an oxygen transporter.	Oxygen	24-30	hemoglobin 1	Arabidopsis thaliana	12-16
9342391-8	1997	AHB2 protein has a lower affinity for oxygen than AHB1 but is similar to AHB1 in having an unusually low, pH-sensitive oxygen off-rate.	Oxygen	119-125	hemoglobin 1	Arabidopsis thaliana	73-77
9339383-1	1997	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates.	Oxygen	174-180	transaldolase 1	Homo sapiens	0-13
9339383-1	1997	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates.	Oxygen	174-180	transaldolase 1	Homo sapiens	15-18
9328930-11	1997	Taken together, results indicate the adrenomedullin (ADM) generated in mesangial cells (MC) can suppress, via activation of the cAMP-protein kinase A (PKA) signaling pathway, reactive oxygen metabolites (ROM) generation in MC and infiltrating macrophages as well as mitogen-activated protein kinase (MAPK)-mediated mitogenesis in MC and vascular smooth muscle cells (VSMC).	Oxygen	184-190	adrenomedullin	Rattus norvegicus	37-51
9329679-5	1997	These observations raise the possibility that A beta peptides in contact with the cerebrovasculature could result in vasoconstriction, hypoperfusion and oxygen free radical imbalance contributing to the neurodegeneration of AD.	Oxygen	153-159	amyloid beta precursor protein	Rattus norvegicus	46-52
9271302-6	1997	Continuous exposure to &gt; 95% O2 was associated with significantly reduced survival time among CCSP -/- mice as compared with strain-, age-, and sex-matched wild-type control mice.	Oxygen	32-34	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	97-101
9277447-5	1997	Localization of message expression of T beta RI and T beta RII in oxygen-exposed rat lung tissue was analyzed by using in situ hybridization.	Oxygen	66-72	transforming growth factor, beta receptor 1	Rattus norvegicus	38-62
9277447-6	1997	T beta RI mRNA expression was found in the interstitium, capillaries, and the alveolar septa of rat lungs exposed for 60 h to 100% oxygen.	Oxygen	131-137	transforming growth factor, beta receptor 1	Rattus norvegicus	0-9
9277447-7	1997	The distribution of T beta RII mRNA in oxygen-exposed rat lung tissue overlapped the localization of T beta RI mRNA.	Oxygen	39-45	transforming growth factor, beta receptor 1	Rattus norvegicus	20-29
9277447-9	1997	We found that expression of T beta RI was upregulated in adult rats undergoing prolonged exposure to 100% oxygen, and the increase of T beta RI expression persisted during 2 wk of repair of lung injury.	Oxygen	106-112	transforming growth factor, beta receptor 1	Rattus norvegicus	28-37
9350418-10	1997	We conclude that reactive oxygen intermediates are involved in ICAM-1 induction by ionizing radiation.	Oxygen	26-32	intercellular adhesion molecule 1	Homo sapiens	63-69
9235919-10	1997	Transcriptional activity of GAL4/HIF-1alpha fusion proteins was increased in cells exposed to 1% O2, cobalt chloride, or desferrioxamine, each of which also increased levels of endogenous HIF-1alpha protein but did not affect fusion protein levels.	Oxygen	97-99	galectin 4	Homo sapiens	28-32
9286152-1	1997	BACKGROUND: Oxygen saturation (SHB) and concentration (CHB) of dermal haemoglobin play an important role in the nutrition of the skin.	Oxygen	12-18	SH2 domain containing adaptor protein B	Homo sapiens	31-34
9286152-12	1997	CONCLUSIONS: During ischemia a decrease of the haemoglobin oxygen saturation (SHB) and tcPO2 was found.	Oxygen	59-65	SH2 domain containing adaptor protein B	Homo sapiens	78-81
9242936-1	1997	To assess the oxygen transport capacity and safety of Neo Red Cells (NRC) with the enzymatic reduction system of methemoglobin in vitro and in experimental animals.	Oxygen	14-20	hemoglobin subunit gamma 2	Homo sapiens	113-126
9253179-2	1997	Mouflon and sheep Hbs appear to be very similar in their response to organic anions and protons, whereas sheep Hb B displays an oxygen affinity lower than that of mouflon Hb B and sheep Hb A. Mouflon Hb B and Hb C, like sheep Hb A and Hb C, have similar efficiencies in transporting oxygen to the tissues.	Oxygen	128-134	hemoglobin subunit beta	Ovis aries	111-115
9225738-3	1997	In vivo hypoxia (5% O2/95% N2 for 30 min) induced mild degenerative neuronal changes (shrunken and eosinophilic somata with picnotic nuclei) in neurons of the CA3, the hilus of the dentate gyrus (DG) and the DG, but not in the CA1.	Oxygen	20-22	carbonic anhydrase 1	Homo sapiens	227-230
9230227-3	1997	We measured arterial oxygen saturation (Sa,O2) and alveolar partial pressure of oxygen (PA,O2) in nine subjects as they climbed from 3,500 to 8,000 m. Four of the climbers reached 8,000 m and one reached the summit.	Oxygen	80-86	immunoglobulin kappa variable 1D-39	Homo sapiens	88-93
9220538-6	1997	Coadministration of plasmid DNA and anti-TNF antibody (but not nonspecific IgG) partially abolished the protective effect and reduced the pulmonary MnSOD activity, suggesting that the plasmid DNA-induced oxygen tolerance was in part mediated by the endogenous TNF and MnSOD.	Oxygen	204-210	superoxide dismutase 2	Rattus norvegicus	148-153
9220538-6	1997	Coadministration of plasmid DNA and anti-TNF antibody (but not nonspecific IgG) partially abolished the protective effect and reduced the pulmonary MnSOD activity, suggesting that the plasmid DNA-induced oxygen tolerance was in part mediated by the endogenous TNF and MnSOD.	Oxygen	204-210	superoxide dismutase 2	Rattus norvegicus	268-273
9312831-13	1997	The purpose of these modifications is to modulate the affinity for O2 (by decreasing the binding of O2 and increasing its delivery to tissue), to reduce the dissociation into monomers and to guard against oxidation into methemoglobin.	Oxygen	67-69	hemoglobin subunit gamma 2	Homo sapiens	220-233
9154936-16	1997	Cytochrome b558 is the essential component of the NADPH oxidase and contains all the redox centers necessary for electron flow between NADPH and oxygen.	Oxygen	145-151	cytochrome b	Bos taurus	0-12
9154936-17	1997	The correlation of the activation and inhibition patterns for O2- generation and INT reduction by cytochrome b558 incorporated into artificial liposomes strongly indicates that the two activities are associated with the same membrane protein, cytochrome b558.	Oxygen	62-64	cytochrome b	Bos taurus	98-110
9154936-17	1997	The correlation of the activation and inhibition patterns for O2- generation and INT reduction by cytochrome b558 incorporated into artificial liposomes strongly indicates that the two activities are associated with the same membrane protein, cytochrome b558.	Oxygen	62-64	cytochrome b	Bos taurus	243-255
9205542-5	1997	With insulin treatment, mechanical efficiency increased to 20,097 +/- 2070 vs. 12,424 +/- 1615 mmHg.mm/ml/O2/100 g in controls.	Oxygen	106-108	insulin	Canis lupus familiaris	5-12
9131041-1	1997	The superoxide (O2-)-generating NADPH oxidase of phagocytic cells is composed of a membrane-bound flavocytochrome (cytochrome b-559) and three cytosolic components, p47-phox, p67-phox, and the small GTPase rac-1 (or 2).	Oxygen	16-18	mitochondrially encoded cytochrome b	Homo sapiens	115-127
9131041-1	1997	The superoxide (O2-)-generating NADPH oxidase of phagocytic cells is composed of a membrane-bound flavocytochrome (cytochrome b-559) and three cytosolic components, p47-phox, p67-phox, and the small GTPase rac-1 (or 2).	Oxygen	16-18	neutrophil cytosolic factor 1	Homo sapiens	165-173
9131041-1	1997	The superoxide (O2-)-generating NADPH oxidase of phagocytic cells is composed of a membrane-bound flavocytochrome (cytochrome b-559) and three cytosolic components, p47-phox, p67-phox, and the small GTPase rac-1 (or 2).	Oxygen	16-18	Rac family small GTPase 1	Homo sapiens	206-217
9131041-3	1997	Electron flow through the redox centers, from NADPH to oxygen, is activated consequent to the assembly of the three cytosolic components with cytochrome b-559.	Oxygen	55-61	mitochondrially encoded cytochrome b	Homo sapiens	142-154
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Oxygen	104-112	antioxidant 1 copper chaperone	Homo sapiens	192-196
9100183-5	1997	Mean VMCA increased during normocapnic inhalation of N2O/O2 (tumor side: 86 +/- 16 cm sec-1; healthy side: 74 +/- 17 cm sec-1) when compared with air (tumor side: 72 +/- 18 cm sec-1; healthy side: 62 +/- 14 cm sec-1, p &lt; 0.01), whereas during hyperventilation VMCA decreased on both sides (p &lt; 0.001).	Oxygen	57-59	secretory blood group 1, pseudogene	Homo sapiens	86-91
9079661-6	1997	Reduced XDH reacts with oxygen in at least 4 bi-molecular steps, with 1.7-1.9 mol of superoxide per mol of XDH formed from the last 2 electrons oxidized.	Oxygen	24-30	xanthine dehydrogenase	Bos taurus	107-110
9079661-8	1997	Steady-state kinetics of xanthine/oxygen and NADH/oxygen turnover of XDH were determined to have kcat values of 2.1 +/- 0.1 and 2.5 +/- 0.9 s-1, respectively, at 25 degrees C, pH 7.5.	Oxygen	50-56	xanthine dehydrogenase	Bos taurus	69-72
9079661-9	1997	XDH is therefore capable of catalyzing the formation of reduced oxygen species at one-third the rate of xanthine/NAD turnover, 6.3 s-1 (Hunt, J., and Massey, V. (1992) J. Biol.	Oxygen	64-70	xanthine dehydrogenase	Bos taurus	0-3
9100937-4	1997	Subjection of conscious young animals to a 4-h HS in a biological oxygen demand (BOD) incubator at 38 degrees C resulted in marked upregulation of c-NOS in the cerebral cortex and hippocampus of stressed rats compared to normal rats kept at room temperature (21 +/- 1 degrees C).	Oxygen	66-72	nitric oxide synthase 3	Rattus norvegicus	147-152
9062344-9	1997	Monoclonal antibodies directed against rat CD18 and ICAM-1, as well as TMB-8, a calcium inhibitor, prevented the calcium mobilization, active oxygen production, and NF-kappaB activation in addition to the increased production of NO.	Oxygen	142-148	intercellular adhesion molecule 1	Rattus norvegicus	52-58
9024014-9	1997	The decreases in O2 deliveries were reflected by moderate disturbances in hepatic and small intestinal surface PO2.	Oxygen	17-19	PO2	Sus scrofa	111-114
9032440-1	1997	Flavocytochrome b558 of the NADPH oxidase which generates superoxide in phagocytic cells, is a alpha1 beta1 heterodimer of gp91phox and p22phox, which together form a membrane-spanning electron-transport chain that transfers electrons from NADPH in the cytosol to oxygen.	Oxygen	264-270	cytochrome b-245 beta chain	Homo sapiens	123-131
9042941-6	1997	Metal rescue experiments revealed that direct metal ion coordination occurs in the functional ribozyme only at the site of cleavage and at the pro-Rp oxygen of position Ag.	Oxygen	150-156	protein only RNase P catalytic subunit	Homo sapiens	143-149
9007460-6	1997	O2 values were determined by three methods: (1) a polarographic electrode, ABL-300 (ABL); (2) a spectrophotometric method, Co-Oximeter (COOX); and (3) a galvanic cell, Lex-O2-Con (LEX).	Oxygen	0-2	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	75-82
9007460-6	1997	O2 values were determined by three methods: (1) a polarographic electrode, ABL-300 (ABL); (2) a spectrophotometric method, Co-Oximeter (COOX); and (3) a galvanic cell, Lex-O2-Con (LEX).	Oxygen	0-2	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	75-78
9068263-1	1997	BACKGROUND: Oxygen saturation (SHB) and concentration (CHB) of dermal hemoglobin are important parameters for the supply of the skin.	Oxygen	12-18	SH2 domain containing adaptor protein B	Homo sapiens	31-34
9216199-14	1996	The effect of recombinant soluble ICAM-1 and its ligands on eosinophil-induced radical oxygen products was studied.	Oxygen	87-93	intercellular adhesion molecule 1	Homo sapiens	34-40
8918370-1	1996	An NADPH-oxidase complex containing at least two protein components (gp91-phox and p22-phox) and a unique low redox potential (-245 mV) cytochrome b-245 is the source of superoxide generated for bacterial killing in neutrophils and has been suggested as the oxygen sensor in the carotid body.	Oxygen	258-264	cytochrome b, mitochondrial	Rattus norvegicus	136-148
8897957-0	1996	Oxygen modulates alpha 1B-adrenergic receptor gene expression by arterial but not venous vascular smooth muscle.	Oxygen	0-6	adrenoceptor alpha 1B	Homo sapiens	17-45
8855199-0	1996	Spermidine acetyltransferase in rat hepatocytes cultured at different oxygen tensions.	Oxygen	70-76	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-28
8763840-7	1996	This suggests that DT-diaphorase activated these agents and the hydroquinone formed caused extensive oxygen activation sufficient to cause DNA oxidative damage and cytotoxicity.	Oxygen	101-107	NAD(P)H dehydrogenase, quinone 1	Mus musculus	19-32
8763840-9	1996	Furthermore, inactivation of DT-diaphorase enhanced cytotoxicity and prevented oxygen activation than group II agents.	Oxygen	79-85	NAD(P)H dehydrogenase, quinone 1	Mus musculus	29-42
8895091-4	1996	With unsulfated dextran, oxyhemoglobin leads to conjugates with increased oxygen affinity (P50/P50 native hemoglobin approximately 0.5) compared to that of free hemoglobin (P50 = 4 mm Hg), whereas deoxyhemoglobin leads to conjugates with decreased oxygen affinity (P50/P50 native hemoglobin approximately 3).	Oxygen	74-80	activating signal cointegrator 1 complex subunit 1	Homo sapiens	91-132
8895091-4	1996	With unsulfated dextran, oxyhemoglobin leads to conjugates with increased oxygen affinity (P50/P50 native hemoglobin approximately 0.5) compared to that of free hemoglobin (P50 = 4 mm Hg), whereas deoxyhemoglobin leads to conjugates with decreased oxygen affinity (P50/P50 native hemoglobin approximately 3).	Oxygen	74-80	activating signal cointegrator 1 complex subunit 1	Homo sapiens	265-306
8895091-5	1996	The use of sulfated dextran reinforces this lowering in oxygen affinity, which indicates that sulfated dextran acts as a permanent macromolecular effector of hemoglobin (P50/P50 native hemoglobin approximately 4).	Oxygen	56-62	activating signal cointegrator 1 complex subunit 1	Homo sapiens	170-211
8895091-7	1996	Although dextran substituted with benzenehexacarboxylic acid (BHC) leads to a low-oxygen-affinity conjugate when linked to oxyhemoglobin through amide bonds (P50/P50 native hemoglobin approximately 5), oxidized dextran modified with BHC leads, with oxyhemoglobin, to a conjugate whose oxygen affinity is close to that of free hemoglobin (P50/P50 native hemoglobin approximately 1.2).	Oxygen	285-291	activating signal cointegrator 1 complex subunit 1	Homo sapiens	158-199
8691452-8	1996	Our results also suggest that the oxygens at C9 and C13 are involved in PKC binding, while the oxygen at C4 is of minimal significance.	Oxygen	34-40	homeobox C13	Homo sapiens	52-55
8690093-3	1996	In order to find out whether the modulation by O2 of PCK gene activation and the stimulation of the ALD A gene by venous O2 operate via H2O2, the effects of different concentrations of H2O2 and catalase as H2O2 scavenger were studied in rat hepatocyte cultures under different O2 tensions.	Oxygen	47-49	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	53-56
8666673-11	1996	Direct cross-linking of the subunits of beta 2 and beta 2 integrins by surface-bound mAbs was elicited O2- production by wild-type PMNs, while the double-mutant hck-/-fgr-/- cells failed to respond.	Oxygen	103-105	hemoglobin, beta adult minor chain	Mus musculus	40-46
8666673-11	1996	Direct cross-linking of the subunits of beta 2 and beta 2 integrins by surface-bound mAbs was elicited O2- production by wild-type PMNs, while the double-mutant hck-/-fgr-/- cells failed to respond.	Oxygen	103-105	hemoglobin, beta adult minor chain	Mus musculus	51-57
8613700-10	1996	Because the lucigenin- and luminol-enhanced chemiluminescence detects, respectively, the O2- production and the myeloperoxidase/hydrogen peroxide halide system, the present data show parallels between deficiency in the production of oxygen-reactive species by PMN and lower fungicidal activity.	Oxygen	233-239	myeloperoxidase	Mus musculus	112-127
8857672-6	1996	It has recently been suggested that superoxide anion is a preferential oxygen substrate for human tyrosinase.	Oxygen	71-77	tyrosinase	Homo sapiens	98-108
8634451-1	1996	The phagocyte cytochrome b558, a heterodimer comprised of gp91phox and p22phox, is a flavocytochrome that mediates the transfer of electrons from NADPH to molecular oxygen in the respiratory burst oxidase.	Oxygen	165-171	cytochrome b-245 beta chain	Homo sapiens	58-66
9206115-3	1996	This study demonstrated that ET-1 (0.1 nmol/L to 100 nmol/L) increased the [3H] thymidine uptake in a dose-dependent manner in cultured bovine pulmonary artery smooth muscle cells (PASMC), which was enhanced by exposing PASMC to hypoxia (2% O2, 93% N2, 5% CO2).	Oxygen	241-243	endothelin 1	Bos taurus	29-33
8720667-1	1996	The inhibitive effects of anti-CD11a/CD18 (LFA-1) and anti-CD54 (ICAM-1) antibodies on the generation of superoxide anion (O2-) by polymorphonuclear leukocytes (PMNs) was elucidated in rats induced with experimental acute pancreatitis.	Oxygen	123-125	intercellular adhesion molecule 1	Rattus norvegicus	65-71
8866724-1	1996	Exposing 7-day-old rat pups to hypoxia, 8% oxygen/92% nitrogen, for 3 h alters glutamate (GLU), glutamine and glutamine synthetase (GS) activity in the striatum, frontal cortex and hippocampus.	Oxygen	43-49	glutamate-ammonia ligase	Rattus norvegicus	110-130
8555249-2	1996	Because UVB irradiation is a potent oxidative stress, the role of active oxygen species in regulating UV-induced cPLA2 synthesis and phosphorylation was examined.	Oxygen	73-79	phospholipase A2 group IVA	Homo sapiens	113-118
8849594-12	1996	When coronary perfusion pressure was decreased, adenosine deaminase sharply lowered cardiac power and O2 utilisation efficiency during isoprenaline stimulation, whereas EHNA augmented isoprenaline-enhanced power and increased efficiency.	Oxygen	102-104	adenosine deaminase	Canis lupus familiaris	48-67
8684589-2	1996	The structures of these polyamine containing compounds are not identical: sFTX-3.3 contains an amide carbonyl oxygen that is absent from the predicted structure of native FTX.	Oxygen	110-116	FTX transcript, XIST regulator	Rattus norvegicus	75-78
8711189-10	1996	However, the elevated levels of methemoglobin and lactates indicate a slight degree of oxygen deficiency in the body.	Oxygen	87-93	hemoglobin subunit gamma 2	Homo sapiens	32-45
8815968-3	1996	5 days" exposure to a low oxygen environment resulted in less weight gain, the development of right ventricular hypertrophy and double elastic laminae in the pulmonary arterioles and an increase in haematocrit and plasma levels of atrial natriuretic peptide (ANP) in both the HB and NB animals compared to controls.	Oxygen	26-32	natriuretic peptide A	Rattus norvegicus	231-257
8815968-3	1996	5 days" exposure to a low oxygen environment resulted in less weight gain, the development of right ventricular hypertrophy and double elastic laminae in the pulmonary arterioles and an increase in haematocrit and plasma levels of atrial natriuretic peptide (ANP) in both the HB and NB animals compared to controls.	Oxygen	26-32	natriuretic peptide A	Rattus norvegicus	259-262
7592416-10	1995	Given the lack of hemT expression under these conditions, we consider FnrL regulation of hemA expression to be a major factor in bringing about changes in the level of ALA synthase activity in response to changes in oxygen tension.	Oxygen	216-222	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	70-74
7472521-5	1995	We found that NMDA receptor blockade using dizocilpine (MK-801), DL-2-amino-5-phosphonovaleric acid (APV), or CGS 19755, was highly effective in reducing CA1 injury in organotypic hippocampal cultures, caused by complete oxygen and glucose deprivation.	Oxygen	221-227	carbonic anhydrase 1	Homo sapiens	154-157
7472521-6	1995	Complete oxygen deprivation alone however, caused CA1 neuronal injury which was not diminished using NMDA receptor blockade alone with MK-801 or APV, or in combination with AMPA/kainate receptor blockade using 6-cyano-7-dinitroquinoxalone-2,3-dione (CNQX).	Oxygen	9-15	carbonic anhydrase 1	Homo sapiens	50-53
8690853-2	1995	Exposure of unanesthetized rats to oxygen deprivation induces activation of the c-fos gene within the nucleus tractus solitarius, resulting in expression of fos-like immunoreactive protein (Fos).	Oxygen	35-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-85
8690853-2	1995	Exposure of unanesthetized rats to oxygen deprivation induces activation of the c-fos gene within the nucleus tractus solitarius, resulting in expression of fos-like immunoreactive protein (Fos).	Oxygen	35-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-85
8690853-2	1995	Exposure of unanesthetized rats to oxygen deprivation induces activation of the c-fos gene within the nucleus tractus solitarius, resulting in expression of fos-like immunoreactive protein (Fos).	Oxygen	35-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	190-193
7485565-1	1995	This report describes a method and instrumentation for determining myoglobin (Mb) oxygen saturation in skeletal muscle.	Oxygen	82-88	myoglobin	Canis lupus familiaris	67-76
7485566-3	1995	Oxygen losses from systemic arterial blood through large and intermediate arterioles (second order, 2A) was 5-7%SHb in both species, and there was no evidence of an increase in percent saturation along intermediate and large venules.	Oxygen	0-6	SH2 domain containing adaptor protein B	Rattus norvegicus	112-115
7654215-2	1995	Adrenaline has recently been shown to stimulate both glucose metabolism and H2O2 release by macrophages but the activity of the key pentose phosphate pathway enzyme, glucose-6-phosphate dehydrogenase (which generates the NADPH crucial for the reduction of molecular oxygen), was reduced under these conditions [Costa Rosa, Safi, Cury and Curi (1992) Biochem.	Oxygen	266-272	glucose-6-phosphate dehydrogenase	Homo sapiens	166-199
8537230-9	1995	In sickle cultures, hemin and low oxygen had additive effects on colony growth, but only low oxygen increased gamma-globin synthesis.	Oxygen	93-99	hemoglobin subunit gamma 1	Homo sapiens	110-122
8537230-11	1995	Interleukin-3 also increased gamma-globin synthesis in low oxygen in normal but not sickle cultures.	Oxygen	59-65	hemoglobin subunit gamma 1	Homo sapiens	29-41
8537230-12	1995	Thus, low oxygen increases in vitro sensitivity to erythropoietin, colony numbers, and relative gamma-globin synthesis in normal and sickle cultures.	Oxygen	10-16	hemoglobin subunit gamma 1	Homo sapiens	96-108
8527646-2	1995	The base-catalyzed exchange rate constants (kOH) of solvent exposed amides in BPTI are lower for residues with low peptide carbonyl exposure, showing that the environment around the carbonyl oxygen influences kOH.	Oxygen	191-197	spleen trypsin inhibitor I	Bos taurus	78-82
7608158-12	1995	Ferrous H64V/V68H myoglobin binds CO and NO to form stable complexes, but its reaction with O2 results in a rapid autooxidation to the ferric species.	Oxygen	92-94	myoglobin	Sus scrofa	18-27
7608158-13	1995	All of these results demonstrate that the three-dimensional positions of His64 and Val68 in the wild-type myoglobin are as important as the chemical nature of the side chains in facilitating reversible O2 binding and inhibiting autooxidation.	Oxygen	202-204	myoglobin	Sus scrofa	106-115
8527265-12	1995	Captopril and MPG (but not enalaprilat) increased, rather than decreased oxygen uptake, when added to PMA-stimulated neutrophils.	Oxygen	73-79	N-methylpurine DNA glycosylase	Homo sapiens	14-17
7663088-0	1995	Effects of maternal ingestion of Aroclor 1254 (PCB) on the developmental pattern of oxygen consumption and body temperature in neonatal rats.	Oxygen	84-90	pyruvate carboxylase	Rattus norvegicus	47-50
7616000-0	1995	Involvement of cytokines, DNA damage, and reactive oxygen intermediates in ultraviolet radiation-induced modulation of intercellular adhesion molecule-1 expression.	Oxygen	51-57	intercellular adhesion molecule 1	Homo sapiens	119-152
7661037-6	1995	We suggest that corneal epithelial cells are constantly exposed to active oxygen stress even under physiological conditions and synthesize Mn-SOD to protect themselves from the stress.	Oxygen	74-80	superoxide dismutase 2	Rattus norvegicus	139-145
24301381-0	1995	Restoration of the high potential form of cytochrome b-559 through the photoreactivation of Tris-inactivated oxygen-evolving center.	Oxygen	109-115	mitochondrially encoded cytochrome b	Homo sapiens	42-54
7779792-2	1995	The rate of reduction of Fea3 (the oxygen-binding heme) is not a linear function of the population of reduced Fea (the low-spin heme), as would be expected if electron transfer between these sites is rate-limiting.	Oxygen	35-41	FEA	Homo sapiens	25-28
7541940-4	1995	However, the response to hypoxia (1% oxygen) varied markedly, ranging from a 13-fold increase (PDGF-B in Hep G2 cells) to a 2-fold decrease (PLGF in the trophoblastic line BeWo).	Oxygen	37-43	platelet derived growth factor subunit B	Homo sapiens	95-101
7611394-1	1995	Reduced O2 availability, as might occur under some physiological and pathological conditions, stimulates insulin and glucagon release and increases glucose fluxes and muscle carbohydrate metabolism.	Oxygen	8-10	insulin	Canis lupus familiaris	105-112
7654490-5	1995	The reactivity of captopril and MPG towards O2-/H2O2 was then determined by measurement of thiol oxidation in captopril and MPG after their incubation with hypoxanthine/xanthine oxidase.	Oxygen	44-46	N-methylpurine DNA glycosylase	Homo sapiens	32-35
7744749-1	1995	Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response of cells exposed to DNA-damaging compounds such as nitric oxide (NO) or reactive oxygen intermediates (ROI).	Oxygen	170-176	poly (ADP-ribose) polymerase family, member 1	Mus musculus	33-60
7744749-1	1995	Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response of cells exposed to DNA-damaging compounds such as nitric oxide (NO) or reactive oxygen intermediates (ROI).	Oxygen	170-176	poly (ADP-ribose) polymerase family, member 1	Mus musculus	62-66
7762683-2	1995	SP-A mRNA levels were increased by 25 and 39% in lung explants incubated in 70 and 95% O2, respectively, compared with levels in tissues incubated in 20% O2.	Oxygen	87-89	surfactant protein A2	Homo sapiens	0-4
7762683-2	1995	SP-A mRNA levels were increased by 25 and 39% in lung explants incubated in 70 and 95% O2, respectively, compared with levels in tissues incubated in 20% O2.	Oxygen	154-156	surfactant protein A2	Homo sapiens	0-4
7762684-0	1995	Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung.	Oxygen	62-68	C-C motif chemokine 2	Oryctolagus cuniculus	18-52
7762684-2	1995	We hypothesized that IL-8 and MCP-1 mRNA expression in alveolar macrophages (AM) lavaged from rabbit lung would be increased by oxygen exposure, which is known to induce inflammation.	Oxygen	128-134	C-C motif chemokine 2	Oryctolagus cuniculus	30-35
7762684-5	1995	Quantitative in situ hybridization with 3H-labeled cRNA probes showed both IL-8 and MCP-1 mRNA expression in AM during oxygen exposure, with peak levels of IL-8 mRNA at 56-h oxygen exposure and of MCP-1 mRNA at 64-h oxygen exposure with 24-h room air recovery.	Oxygen	119-125	C-C motif chemokine 2	Oryctolagus cuniculus	84-89
7649929-2	1995	The findings support previous photometric studies that indicate that carotid body type I cells possess a putative oxygen sensor protein that is similar to the neutrophil NAD(P)H oxidase and consists of a hydrogen peroxide generating low-potential cytochrome b558 with cofactors regulating the electron transfer to oxygen.	Oxygen	114-120	mitochondrially encoded cytochrome b	Homo sapiens	247-259
7649929-2	1995	The findings support previous photometric studies that indicate that carotid body type I cells possess a putative oxygen sensor protein that is similar to the neutrophil NAD(P)H oxidase and consists of a hydrogen peroxide generating low-potential cytochrome b558 with cofactors regulating the electron transfer to oxygen.	Oxygen	314-320	mitochondrially encoded cytochrome b	Homo sapiens	247-259
7796152-4	1995	Acea 1021 and 7-chlorokynurenic acid significantly reduced CA1 injury produced by oxygen and glucose deprivation in a dose-dependent manner.	Oxygen	82-88	carbonic anhydrase 1	Homo sapiens	59-62
7876265-2	1995	The palmitoyl-CoA oxidase (ACOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2.	Oxygen	150-156	acyl-CoA oxidase 1	Homo sapiens	4-25
7876265-2	1995	The palmitoyl-CoA oxidase (ACOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2.	Oxygen	150-156	acyl-CoA oxidase 1	Homo sapiens	27-31
7873200-4	1995	In this study, we demonstrated that coinsufflation of LPS with anti-TNF antibody and IL-1 receptor antagonist (IL-1ra), which completely inhibited LPS-induced TNF and IL-1 activities, had no effect on LPS-induced alveolar inflammatory response and O2 tolerance.	Oxygen	248-250	interleukin 1 receptor antagonist	Rattus norvegicus	85-109
7873200-4	1995	In this study, we demonstrated that coinsufflation of LPS with anti-TNF antibody and IL-1 receptor antagonist (IL-1ra), which completely inhibited LPS-induced TNF and IL-1 activities, had no effect on LPS-induced alveolar inflammatory response and O2 tolerance.	Oxygen	248-250	interleukin 1 receptor antagonist	Rattus norvegicus	111-117
7873200-6	1995	In contrast, IL-1ra completely abolished IL-1-induced inflammatory response and markedly inhibited IL-1-induced O2 tolerance.	Oxygen	112-114	interleukin 1 receptor antagonist	Rattus norvegicus	13-19
7836366-6	1995	Comparison of the rate of iron oxidation to O2 consumption yielded an approximate value of 4:1, as predicted for a ferroxidase.	Oxygen	44-46	ferroxidase	Saccharomyces cerevisiae S288C	115-126
7836366-8	1995	Treatment of spheroplasts with trypsin or affinity-purified antibodies directed against the putative external ferroxidase domain of Fet3 had no effect on basal O2 consumption but inhibited the iron-dependent increase in O2 consumption.	Oxygen	220-222	ferroxidase	Saccharomyces cerevisiae S288C	110-121
7731169-10	1995	In the absence of lipoproteins, renin release was significantly stimulated by activation of O2- formation by the xanthine/xanthine oxidase reaction.	Oxygen	92-94	xanthine dehydrogenase	Mus musculus	122-138
21043622-10	1995	These data suggest that the protective effect of dipyridamole against oxygen stress is correlated with the increase in the cyclic GMP content of the endothelial cells.	Oxygen	70-76	5'-nucleotidase, cytosolic II	Homo sapiens	130-133
7827938-5	1994	Administration of as little as 1.0 ng kg-1 PAF caused a significant decrease in adenosine 5"-triphosphate concentration and oxygen consumption (P &lt; 0.05), although non-parenchymal cell injury was not affected.	Oxygen	124-130	PCNA clamp associated factor	Rattus norvegicus	43-46
7964741-1	1994	Both CA1 and dentate gyrus regions of the hippocampal slice exhibit an irreversible loss of synaptic transmission after exposure to in vitro ischemic conditions (buffer without oxygen and glucose).	Oxygen	177-183	carbonic anhydrase 1	Homo sapiens	5-8
7899254-2	1994	In these studies we suggested that atrial natriuretic peptide may be physiologically important for protection of the myocardium during periods of oxygen deficit.	Oxygen	146-152	natriuretic peptide A	Rattus norvegicus	35-61
7899254-10	1994	We conclude that atrial natriuretic peptide protects the working ventricular myocardium during hypoxia, which further supports our previously reported suggestion that the effect on myocardial metabolism is physiologically relevant during situations of oxygen deficit in heart muscle.	Oxygen	252-258	natriuretic peptide A	Rattus norvegicus	17-43
7960991-10	1994	CONCLUSIONS: One potential mechanism of aerobic cytotoxicity is redox cycling of SR 4233 with molecular oxygen resulting in several potentially toxic oxidative species that overburden the intrinsic intracellular detoxification systems such as superoxide dismutase, catalase, and glutathione peroxidase.	Oxygen	104-110	catalase	Cricetulus griseus	265-273
7850393-0	1994	Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water.	Oxygen	35-41	complement C3	Homo sapiens	65-68
7850393-0	1994	Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water.	Oxygen	35-41	complement C3	Homo sapiens	114-117
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Oxygen	0-6	complement C3	Homo sapiens	18-21
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Oxygen	0-6	complement C3	Homo sapiens	67-70
7528533-1	1994	Fetal blood normally has a higher oxygen affinity than maternal blood because of the predominance of haemoglobin (Hb) F in the former and of Hb A in the latter; this predominance facilitates the transfer of oxygen from maternal to fetal blood.	Oxygen	34-40	sodium voltage-gated channel alpha subunit 2	Homo sapiens	141-145
7528533-1	1994	Fetal blood normally has a higher oxygen affinity than maternal blood because of the predominance of haemoglobin (Hb) F in the former and of Hb A in the latter; this predominance facilitates the transfer of oxygen from maternal to fetal blood.	Oxygen	207-213	sodium voltage-gated channel alpha subunit 2	Homo sapiens	141-145
7528533-5	1994	We conclude that the differential oxygen affinity produced by the combination of Hb A in the maternal blood and Hb F in the fetal blood is not indispensable to ensure an oxygen supply adequate for normal fetal development and growth.	Oxygen	34-40	sodium voltage-gated channel alpha subunit 2	Homo sapiens	81-85
24177888-3	1994	To utilize the potential of opaque-2 maize, elite inbreds can be converted to o2/o2 forms and subsequently to hard endosperm opaque-2.	Oxygen	78-80	regulatory protein opaque-2	Zea mays	28-36
24177888-3	1994	To utilize the potential of opaque-2 maize, elite inbreds can be converted to o2/o2 forms and subsequently to hard endosperm opaque-2.	Oxygen	81-83	regulatory protein opaque-2	Zea mays	28-36
7822689-8	1994	The assessment of oxygen radical release from AM after overnight exposure to CdCl2 showed a dose-dependent decrease to 54.3 +/- 8.2%, 32.2 +/- 4.3% and 25 +/- 3% of control after exposure to 0.1, 0.4 and 0.8 ppm Cd2+, respectively.	Oxygen	18-24	T-cell surface antigen CD2	Cavia porcellus	212-215
8209390-4	1994	The maximal induction of P450 isoenzymes CYP2B1/2B2 (20- to 25-fold) and CYP2C6 (6-fold) were found at 0.75 mM PB at both oxygen tensions.	Oxygen	122-128	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	73-79
8198547-4	1994	We report here that in the presence of molecular O2, copper and PAM substrate, NN-dimethyl-1,4-phenylenediamine (DMPD) serves as the requisite electron donor for the mono-oxygenase, being oxidized in the process to a stable and highly chromophoric cation radical.	Oxygen	49-51	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	64-67
8013298-2	1994	The factors of oxygen in the blood--content, saturation of hemoglobin, O2 partial pressure--are diminished continuously during anaesthesia, with a decrease of pO2 on 77% of the initial value.	Oxygen	15-21	HGB	Sus scrofa	59-69
8087190-7	1994	In contrast, ECP concentrations were strongly inversely correlated with initial oxygen saturation.	Oxygen	80-86	ribonuclease A family member 3	Homo sapiens	13-16
8016773-10	1994	In addition, ECP was related to arterial oxygen and carbon dioxide tensions.	Oxygen	41-47	ribonuclease A family member 3	Homo sapiens	13-16
8135857-3	1994	In the renal cortex fragment suspension, both Cd2+ and nystatin increased the ouabain-sensitive, basal oxygen consumption and inhibited the rate of glucose production from pyruvate, but not from lactate.	Oxygen	103-109	Cd2 molecule	Rattus norvegicus	46-49
8005437-1	1994	Transcription of HEM13 in Saccharomyces cerevisiae is repressed by heme and oxygen.	Oxygen	76-82	coproporphyrinogen oxidase	Saccharomyces cerevisiae S288C	17-22
8016203-1	1994	The rate constants for the reactive (kR) and unreactive (kQ) interaction of singlet molecular oxygen with three esters of polyunsaturated fatty acids (PUFA: cis-methyl oleate, MO; cis-methyl linoleate, MLA and cis-ethyl linolenate, ELN) are determined.	Oxygen	76-100	pumilio RNA binding family member 3	Homo sapiens	151-155
8016203-1	1994	The rate constants for the reactive (kR) and unreactive (kQ) interaction of singlet molecular oxygen with three esters of polyunsaturated fatty acids (PUFA: cis-methyl oleate, MO; cis-methyl linoleate, MLA and cis-ethyl linolenate, ELN) are determined.	Oxygen	76-100	elastin	Homo sapiens	232-235
8110468-0	1994	Lung manganese superoxide dismutase increases during cytokine-mediated protection against pulmonary oxygen toxicity in rats.	Oxygen	100-106	superoxide dismutase 2	Rattus norvegicus	5-35
8141312-0	1994	Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension.	Oxygen	90-96	xanthine dehydrogenase	Bos taurus	31-53
8148419-3	1994	The purified abnormal hemoglobin, like Hb J Cape Town, another variant of position alpha 92(FG4), displayed only a 1.5- to 2-fold increased oxygen affinity and a reduced cooperativity.	Oxygen	140-146	hemoglobin subunit gamma 2	Homo sapiens	13-32
7833545-3	1994	Maximum extrapolated oxygen transfer of the Maxima Plus (444 ml O2/minute) was increased 23.68% when compared to the Maxima (359 ml O2/minute).	Oxygen	21-27	immunoglobulin kappa variable 1D-39	Homo sapiens	64-73
7833545-3	1994	Maximum extrapolated oxygen transfer of the Maxima Plus (444 ml O2/minute) was increased 23.68% when compared to the Maxima (359 ml O2/minute).	Oxygen	21-27	immunoglobulin kappa variable 1D-39	Homo sapiens	132-141
7505388-10	1993	Oxygen consumption by intact gef1- cells and by mitochondrial fractions isolated from gef1- mutants was reduced 25-50% relative to wild type, indicating that mitochondrial function is defective in these mutants.	Oxygen	0-6	Gef1p	Saccharomyces cerevisiae S288C	29-33
7505388-10	1993	Oxygen consumption by intact gef1- cells and by mitochondrial fractions isolated from gef1- mutants was reduced 25-50% relative to wild type, indicating that mitochondrial function is defective in these mutants.	Oxygen	0-6	Gef1p	Saccharomyces cerevisiae S288C	86-90
8241293-2	1993	This abnormal hemoglobin displays a very high oxygen affinity and a markedly reduced cooperativity that is partly restored in the presence of IHP.	Oxygen	46-52	hemoglobin subunit gamma 2	Homo sapiens	5-24
8227170-0	1993	Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts.	Oxygen	4-10	collagen type I alpha 1 chain	Homo sapiens	44-67
8227170-3	1993	By Northern blot analysis the steady state levels of alpha 1 (I) procollagen mRNA were increased by 75 to 150% of control (standard oxygen) as early as 12 hours and more than 200% 96 hours after exposure of cells to low oxygen.	Oxygen	132-138	collagen type I alpha 1 chain	Homo sapiens	53-76
8227170-3	1993	By Northern blot analysis the steady state levels of alpha 1 (I) procollagen mRNA were increased by 75 to 150% of control (standard oxygen) as early as 12 hours and more than 200% 96 hours after exposure of cells to low oxygen.	Oxygen	220-226	collagen type I alpha 1 chain	Homo sapiens	53-76
8227170-6	1993	We conclude that low oxygen tension enhances steady state mRNA levels of alpha 1 (I) procollagen, and that this effect is mediated at least in part by TGF-beta 1.	Oxygen	21-27	collagen type I alpha 1 chain	Homo sapiens	73-96
8396125-3	1993	Following brief exposure of rats to ozone (2 ppm, 3 h), a pulmonary irritant and inflammatory agent that is rapidly converted to molecular oxygen, expression of PAF receptors was markedly up-regulated on lung phagocytes (13.1 x 10(3) binding sites/cell), with no significant effect on receptor affinity (Kd = 2.0 nM).	Oxygen	139-145	PCNA clamp associated factor	Rattus norvegicus	161-164
8352753-0	1993	Oxygen Michaelis constants for tyrosinase.	Oxygen	0-6	tyrosinase	Homo sapiens	31-41
8352753-1	1993	The Michaelis constant of tyrosinase for oxygen in the presence of monophenols and o-diphenols, which generate a cyclizable o-quinone, has been studied.	Oxygen	41-47	tyrosinase	Homo sapiens	26-36
8353957-1	1993	When cyanide poisoning is treated with a methemoglobin-forming agent, oxidative metabolism is protected at the expense of the oxygen capacity of the blood.	Oxygen	126-132	hemoglobin subunit gamma 2	Homo sapiens	41-54
8353957-2	1993	The affinity of methemoglobin for CN- is high enough to compete with cytochrome oxidase, which protects the latter from becoming blocked, but all hemoglobin used for this purpose is lost for the transport of oxygen.	Oxygen	208-214	hemoglobin subunit gamma 2	Homo sapiens	16-29
12231875-2	1993	The activities of superoxide dismutase (SOD), ascorbate peroxidase, and monodehydroascorbate reductase increased significantly on prolonged illumination of the leaves, indicating an increase in the rate of generation of active oxygen species.	Oxygen	227-233	SOD	Triticum aestivum	18-38
12231875-2	1993	The activities of superoxide dismutase (SOD), ascorbate peroxidase, and monodehydroascorbate reductase increased significantly on prolonged illumination of the leaves, indicating an increase in the rate of generation of active oxygen species.	Oxygen	227-233	SOD	Triticum aestivum	40-43
8481234-7	1993	In this study, in situ hybridization of Mn-SOD in the lungs of adult rats exposed to air or to 85% O2 for 3 days was performed.	Oxygen	99-101	superoxide dismutase 2	Rattus norvegicus	40-46
8481234-8	1993	In animals exposed to either air or 85% O2, Mn-SOD transcripts were present in arterioles, the septal tips of alveolar ducts, alveolar type II cells, and mesothelial cells.	Oxygen	40-42	superoxide dismutase 2	Rattus norvegicus	44-50
8481234-10	1993	The high level of expression of Mn-SOD mRNA in alveolar duct septal tips in both control and O2-exposed animals may be secondary to increased aerobic activity in these regions, which contain collagen and elastin and are important stress-bearing elements in the lung.	Oxygen	93-95	superoxide dismutase 2	Rattus norvegicus	32-38
8481234-10	1993	The high level of expression of Mn-SOD mRNA in alveolar duct septal tips in both control and O2-exposed animals may be secondary to increased aerobic activity in these regions, which contain collagen and elastin and are important stress-bearing elements in the lung.	Oxygen	93-95	elastin	Rattus norvegicus	204-211
8218940-5	1993	Treatment with IL-2 increased the number of polymorphonuclear cells in the milk, enhanced their inducible oxygen radical formation, and enhanced their phagocytosis.	Oxygen	106-112	interleukin 2	Bos taurus	15-19
8479978-6	1993	The animals were divided into six groups: (1) sham, no ischemia, (2) 4 hours of global ischemia only, (3) no ischemia plus hyperbaric oxygen (one 2.5 ATA/1 hour of treatment with 100% oxygen), (4) 4 hours of ischemia plus hyperbaric oxygen during ischemia, (5) 4 hours of ischemia plus hyperbaric oxygen immediately on reperfusion, and (6) 4 hours of ischemia plus hyperbaric oxygen 1 hour after reperfusion.	Oxygen	134-140	solute carrier family 38, member 1	Rattus norvegicus	150-155
8478901-13	1993	In this conformer, Ca2+ was coordinated to two methoxy oxygens from each of the two drug molecules.	Oxygen	55-62	carbonic anhydrase 2	Homo sapiens	19-22
8479820-7	1993	rIFN, M-CSF, and a combination of the cytokines stimulates oxygen-derived free radical production by white cells and increased bone resorption.	Oxygen	59-65	colony stimulating factor 1 (macrophage)	Mus musculus	6-11
8385232-1	1993	Maximum deactivation of the contractile elements using Ca2+ minimizes oxygen requirements during global ischemia, Ca2+ antagonists and Ca(2+)-free cardioplegia solutions are methods by which the Ca2+ flux can be manipulated.	Oxygen	70-76	carbonic anhydrase 2	Homo sapiens	55-58
8447373-8	1993	In contrast, 3% oxygen caused a marked specific increase in GLUT-1 protein in both plasma membranes and microsomes.	Oxygen	16-22	solute carrier family 2 member 1	Homo sapiens	60-66
8433009-1	1993	The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells.	Oxygen	41-47	tyrosinase	Homo sapiens	115-125
8325038-6	1993	Recent observations implying reactive oxygen as the transduction signal that mediates activation of c-fos and c-jun genes are presently considered to provide an explanation for the induction of GST gene expression by chemical agents of diverse structure.	Oxygen	38-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
8282233-2	1993	Under pure oxygen, the spin adduct PBN/.OCH3 was rapidly generated by the addition of Fe2+ (0.2-1.2 mM) into phosphate buffer containing ethylenediaminetetraacetate (EDTA), dimethyl sulfoxide and PBN at pH 7.4, but it decayed.	Oxygen	11-17	spindlin 1	Homo sapiens	23-27
8396553-1	1993	It is well known that oxygen enhances the relaxation of free radical EPR probes through spin lattice and Heisenberg spin-spin interactions with consequent effect on the line height and width.	Oxygen	22-28	spindlin 1	Homo sapiens	88-92
8396553-1	1993	It is well known that oxygen enhances the relaxation of free radical EPR probes through spin lattice and Heisenberg spin-spin interactions with consequent effect on the line height and width.	Oxygen	22-28	spindlin 1	Homo sapiens	116-120
8396553-1	1993	It is well known that oxygen enhances the relaxation of free radical EPR probes through spin lattice and Heisenberg spin-spin interactions with consequent effect on the line height and width.	Oxygen	22-28	spindlin 1	Homo sapiens	116-120
8396553-3	1993	During EPR studies of chemical, biochemical, and cellular processes involving free radicals, molecular oxygen has significant magnetic influence on the EPR signal intensity of the free radical species under investigation in addition to affecting the rates of production of the primary species and the stability of the spin adduct nitroxides.	Oxygen	103-109	spindlin 1	Homo sapiens	318-322
8396553-5	1993	In the present study, the effects of oxygen and ferricyanide on the EPR signal height of stable and persistent spin adduct nitroxides at commonly employed microwave powers were examined.	Oxygen	37-43	spindlin 1	Homo sapiens	111-115
8396553-6	1993	The results show that under commonly adopted EPR spectrometer instrumental conditions, artifactual changes in the EPR signal of spin adducts occur and the best way to avoid them is by keeping the oxygen level constant using a gas-permeable cell.	Oxygen	196-202	spindlin 1	Homo sapiens	128-132
8417495-12	1993	We conclude that in the three models of pancreatitis (FFA, POSS, and ISCH 2) that are mediated by toxic oxygen metabolites, XD is converted to XO reversibly by way of sulfhydryl group oxidation rather than irreversibly by way of proteolysis.	Oxygen	104-110	xanthine dehydrogenase	Canis lupus familiaris	124-126
1332956-1	1992	It is known that in respiratory burst oxidase preparations engaged in O2- production, cytochrome b558, a characteristic oxidase component, is partly reduced.	Oxygen	70-72	mitochondrially encoded cytochrome b	Homo sapiens	86-98
1472082-9	1992	7-Deoxyaglycone metabolite formation by purified cytochrome P450 reductase had an absolute requirement for NADPH as co-factor, was inhibited by molecular oxygen and dicoumarol (IC50 approx.	Oxygen	154-160	cytochrome p450 oxidoreductase	Rattus norvegicus	49-74
1287662-3	1992	We have further characterized the oxygen-binding properties, as well as the tetramer stability, of recombinant human Hb A made in yeast.	Oxygen	34-40	sodium voltage-gated channel alpha subunit 2	Homo sapiens	117-121
1445880-0	1992	Photooxidation of cytochrome b559 in oxygen-evolving photosystem II.	Oxygen	37-43	mitochondrially encoded cytochrome b	Homo sapiens	18-30
1443133-7	1992	Treatment of animals with either of two PAF receptor antagonists (BN 52021 and WEB 2170) partially prevented the increase in tissue levels of eicosanoids and O2-derived free radicals and partially alleviated liver injury as judged by the appearance of glutamate-pyruvate transaminase in the plasma of jaundiced rats.	Oxygen	158-160	PCNA clamp associated factor	Rattus norvegicus	40-43
1332032-0	1992	O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA.	Oxygen	0-2	neutrophil cytosolic factor 1	Homo sapiens	78-85
1332032-0	1992	O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA.	Oxygen	0-2	neutrophil cytosolic factor 1	Homo sapiens	144-151
1332032-5	1992	We report here that O2- production was partly restored to phorbol 12-myristate 13-acetate-stimulated Epstein-Barr virus-transformed B lymphocytes from a patient with p47phox-deficient chronic granulomatous disease by transfection with an expression plasmid containing a p47phox cDNA inserted in the sense direction.	Oxygen	20-22	neutrophil cytosolic factor 1	Homo sapiens	166-173
1332032-7	1992	The finding that O2- can be produced by p47phox-deficient B lymphocytes after the transfer of a p47phox cDNA into the deficient cells suggests that this system could be useful for studying the function of mutant p47phox proteins in whole cells.	Oxygen	17-19	neutrophil cytosolic factor 1	Homo sapiens	40-47
1332032-7	1992	The finding that O2- can be produced by p47phox-deficient B lymphocytes after the transfer of a p47phox cDNA into the deficient cells suggests that this system could be useful for studying the function of mutant p47phox proteins in whole cells.	Oxygen	17-19	neutrophil cytosolic factor 1	Homo sapiens	96-103
1332032-7	1992	The finding that O2- can be produced by p47phox-deficient B lymphocytes after the transfer of a p47phox cDNA into the deficient cells suggests that this system could be useful for studying the function of mutant p47phox proteins in whole cells.	Oxygen	17-19	neutrophil cytosolic factor 1	Homo sapiens	96-103
1397323-0	1992	Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures.	Oxygen	97-103	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	55-88
1397323-2	1992	The glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene is modulated by oxygen.	Oxygen	102-108	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	41-74
1397323-2	1992	The glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene is modulated by oxygen.	Oxygen	102-108	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	76-79
1526970-3	1992	In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine.	Oxygen	39-45	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	127-131
1499941-1	1992	Cellular protection from immune-generated oxygen free radicals is initiated by the reduction of oxygen radicals by manganese superoxide dismutase (MnSOD) and copper/zinc superoxide dismutase (Cu/ZnSOD).	Oxygen	42-48	superoxide dismutase 2	Rattus norvegicus	115-145
1499941-1	1992	Cellular protection from immune-generated oxygen free radicals is initiated by the reduction of oxygen radicals by manganese superoxide dismutase (MnSOD) and copper/zinc superoxide dismutase (Cu/ZnSOD).	Oxygen	42-48	superoxide dismutase 2	Rattus norvegicus	147-152
1635086-10	1992	CONCLUSIONS: Xanthine dehydrogenase-activated mitomycin C appears to be a good alkylating species but a relatively poor generator of reactive oxygen when compared with xanthine oxidase activation under aerobic conditions.	Oxygen	142-148	xanthine dehydrogenase	Mus musculus	13-35
1621630-4	1992	Nitrites are absorbed and form methemoglobin, which interferes with the oxygen-carrying capacity of hemoglobin.	Oxygen	72-78	hemoglobin subunit gamma 2	Homo sapiens	31-44
1458186-2	1992	This action of OBQ was due to its capacity to activate the recovery of blood oxygen transport function by accelerating the restoration of methemoglobin and determined by their electron-acceptor properties, lipophilicity and NADP-dependent methemoglobin reductase affinity.	Oxygen	77-83	hemoglobin subunit gamma 2	Homo sapiens	138-151
1407263-7	1992	The addition of almitrine antagonized the decrease of the Mn-SOD activity observed in the low oxygen pressure treated cells, but results clearly point-out the importance of oxygen radical production in the astroglial response after hypoxic injury.	Oxygen	94-100	superoxide dismutase 2	Rattus norvegicus	58-64
1320299-8	1992	Neutrophil superoxide anion production (O2-) was assessed in a kinetic fashion (in nanomoles per minute) by superoxide dismutase-inhibitable cytochrome C reduction (phorbol myristate acetate stimulation).	Oxygen	40-42	cytochrome c	Sus scrofa	141-153
1616021-6	1992	Glucose uptake was increased by insulin during the control period (from 0.09 to 0.39 mumol.min-1.g-1), so that the combined extraction of glucose and lactate exceeded the requirement for oxidizable substrate calculated from oxygen consumption.	Oxygen	224-230	insulin	Canis lupus familiaris	32-39
1614224-4	1992	The mean and maximum lifespan of the zyg-9(b244) mutant under 60 and 90% oxygen shrunk by 18 and 22%, and 38 and 39%, respectively, as compared with those under 21% oxygen.	Oxygen	73-79	Zygote defective protein 9	Caenorhabditis elegans	37-42
1614224-4	1992	The mean and maximum lifespan of the zyg-9(b244) mutant under 60 and 90% oxygen shrunk by 18 and 22%, and 38 and 39%, respectively, as compared with those under 21% oxygen.	Oxygen	165-171	Zygote defective protein 9	Caenorhabditis elegans	37-42
1525853-0	1992	The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism.	Oxygen	89-95	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
1316998-5	1992	These analyses showed that, in the presence of glucose, transcription of CYT1 is positively controlled by oxygen, presumably through the haem signal, and mediated by the HAP1-encoded transactivator.	Oxygen	106-112	ubiquinol--cytochrome-c reductase catalytic subunit CYT1	Saccharomyces cerevisiae S288C	73-77
1547238-8	1992	The coordination of the Ca2+ ions with Gla carboxylate oxygen atoms and water molecules leads to distorted polyhedral arrangements with mu-oxo bridges in a highly complex array that most likely orchestrates the folding of the domain.	Oxygen	55-61	galactosidase alpha	Homo sapiens	39-42
1547238-14	1992	Since most of the carboxylate oxygen atoms of Gla residues are involved in Ca2+ ion binding, leaving only a few for bridging Ca2+ ion-phospholipid interactions, the role of bridging Ca2+ ions might be generally unspecific, with Ca2+ ions simply intervening between the negative Gla domain and negative head groups of the membrane surface.	Oxygen	30-36	galactosidase alpha	Homo sapiens	46-49
1312781-9	1992	The content of GLUT1 glucose transporter was significantly elevated in total membranes of cells incubated in 3% O2 and depressed in membranes from cells incubated in hyperoxic conditions, whereas GLUT4 expression was not affected.	Oxygen	112-114	solute carrier family 2 member 1	Homo sapiens	15-20
1311514-4	1992	PDGF-B chain mRNA was increased by 6 days and PDGF B-type receptor mRNA was increased by 4 and 6 days of exposure to 85% O2.	Oxygen	121-123	platelet derived growth factor subunit B	Rattus norvegicus	46-52
1311514-9	1992	We speculate that the early pulmonary fibroblast hyperplasia observed following exposure to 85% O2 is mediated by increased PDGF-B chain gene expression and may also be mediated by changes in PDGF B-type receptor gene expression.	Oxygen	96-98	platelet derived growth factor subunit B	Rattus norvegicus	124-130
1311514-9	1992	We speculate that the early pulmonary fibroblast hyperplasia observed following exposure to 85% O2 is mediated by increased PDGF-B chain gene expression and may also be mediated by changes in PDGF B-type receptor gene expression.	Oxygen	96-98	platelet derived growth factor subunit B	Rattus norvegicus	192-198
1735173-4	1992	Arterial PO2 was controlled by manipulating inspired oxygen concentration (FIO2).	Oxygen	53-59	PO2	Sus scrofa	9-12
1730033-1	1992	1,2-Propanediol oxidoreductase, which reduces the L-lactaldehyde formed in the fermentation of L-fucose or L-rhamnose to L-1,2-propanediol in E. coli, was inactivated by a component of E. coli cell extracts in the presence of oxygen.	Oxygen	226-232	oxidoreductase	Escherichia coli	16-30
1730033-5	1992	Propanediol oxidoreductase was rapidly degraded in the presence of oxygen, while the native enzyme displayed high stability as long as no oxygen was present.	Oxygen	67-73	oxidoreductase	Escherichia coli	12-26
1730033-5	1992	Propanediol oxidoreductase was rapidly degraded in the presence of oxygen, while the native enzyme displayed high stability as long as no oxygen was present.	Oxygen	138-144	oxidoreductase	Escherichia coli	12-26
1728718-2	1992	In vitro immunoglobulin fractions denatured by oxygen bubbling produced C4a, C3a, and C5a, but albumin identically treated did not.	Oxygen	47-53	complement C3	Homo sapiens	77-80
1598444-3	1992	We used a CPAP system with continuous O2 flow limited by an underwater valve at a pressure of +5 cmH2O.	Oxygen	38-40	centromere protein J	Homo sapiens	10-14
1798278-4	1991	The soluble form of guanylate cyclase in vascular smooth muscle, an enzyme which produces the intracellular mediator of relaxation cyclic GMP, is also a site of action of vasoactive O2 metabolites.	Oxygen	182-184	5'-nucleotidase, cytosolic II	Homo sapiens	138-141
1810265-4	1991	The direct exposure of G6-PDH to active oxygen species led to different results.	Oxygen	40-46	glucose-6-phosphate dehydrogenase	Homo sapiens	23-29
1810265-10	1991	The results suggest that .O2- is the potent species towards G6-PDH, if dithranol acts through formation of active oxygen species.	Oxygen	26-28	glucose-6-phosphate dehydrogenase	Homo sapiens	60-66
1810265-10	1991	The results suggest that .O2- is the potent species towards G6-PDH, if dithranol acts through formation of active oxygen species.	Oxygen	114-120	glucose-6-phosphate dehydrogenase	Homo sapiens	60-66
1919701-2	1991	The oxygen radical scavengers superoxide dismutase and catalase restore normal reactivity; however, they are not routinely available for clinical use.	Oxygen	4-10	catalase	Felis catus	55-63
1914551-6	1991	Of interest, two patients did have a marked improvement in FEV1 associated with improved oxygen saturation on the CPAP night.	Oxygen	89-95	centromere protein J	Homo sapiens	114-118
1759089-4	1991	Effective CPAP (9 +/- 3 cm H2O) was documented in 320 patients on single night studies and resulted in a 99% reduction in the frequency of obstructive events and improvement in the lowest O2 saturation to 94 +/- 5%.	Oxygen	188-190	centromere protein J	Homo sapiens	10-14
1910812-3	1991	Northern blot analysis indicated that: (1) heat shock induced a rapid and marked increase in hsp70 mRNA levels that reached a maximum during recovery from a 30-min exposure to 45 degrees C; (2) treatment with a 5-mM H2O2 bolus or 50 mU/ml xanthine oxidase also increased hsp70 mRNA levels but to a lesser extent than heat shock (about 10 and 25 times less, respectively); (3) no change was detected after a 5-day exposure to 95% O2.	Oxygen	218-220	heat shock protein family A (Hsp70) member 4	Homo sapiens	93-98
1910812-3	1991	Northern blot analysis indicated that: (1) heat shock induced a rapid and marked increase in hsp70 mRNA levels that reached a maximum during recovery from a 30-min exposure to 45 degrees C; (2) treatment with a 5-mM H2O2 bolus or 50 mU/ml xanthine oxidase also increased hsp70 mRNA levels but to a lesser extent than heat shock (about 10 and 25 times less, respectively); (3) no change was detected after a 5-day exposure to 95% O2.	Oxygen	218-220	heat shock protein family A (Hsp70) member 4	Homo sapiens	271-276
1655340-4	1991	Continuous intravenous infusion of two doses of synthetic rat atrial natriuretic peptide, 300 ng/h per rat (0.10 pmol/h per rat) and 800 ng/h per rat (0.28 pmol/h per rat), attenuated the development of pulmonary hypertension in rats exposed to chronic hypoxia (fractional concentration of oxygen in inspired air = 10%) for 7 days: (i) the pulmonary artery pressure (mean +/- SD) in the vehicle-treated hypoxic group was 45 +/- 6 mmHg compared with 28 +/- 6 mmHg in the vehicle-treated normotoxic group (n = 8, P less than 0.001); (ii) treatment with atrial natriuretic peptide in normoxia did not alter the pulmonary artery pressure, systemic blood pressure or heart rate; (iii) treatment with atrial natriuretic peptide in hypoxia resulted in a lower pulmonary artery pressure in the group treated with 800 ng of atrial natriuretic peptide/h per rat (38 +/- 8 mmHg, P less than 0.05 compared with the vehicle-treated hypoxic group) without affecting the systemic blood pressure or heart rate.	Oxygen	290-296	natriuretic peptide A	Rattus norvegicus	62-88
1938743-6	1991	The protection against O2 toxicity was associated with a selective enhancement of pulmonary Mn-superoxide dismutase (Mn-SOD) activity in IL-1-insufflated rats.	Oxygen	23-25	superoxide dismutase 2	Rattus norvegicus	92-115
1938743-6	1991	The protection against O2 toxicity was associated with a selective enhancement of pulmonary Mn-superoxide dismutase (Mn-SOD) activity in IL-1-insufflated rats.	Oxygen	23-25	superoxide dismutase 2	Rattus norvegicus	117-123
1938743-7	1991	In rats insufflated with IL-1 that survived exposure to 100% O2 for 7 days, the activities of pulmonary Mn-SOD, Cu,Zn-SOD, catalase, and glutathione peroxidase were all increased.	Oxygen	61-63	superoxide dismutase 2	Rattus norvegicus	104-110
1938743-8	1991	The increased pulmonary Mn-SOD activity demonstrated in IL-1-insufflated rats at 2.3 days after O2 exposure may contribute to the protection against acute O2 toxicity, and the markedly increased activities of all pulmonary antioxidant enzymes shown in rats insufflated with IL-1 that survived O2 exposure for 7 days may in part be responsible for the chronic adaptation of these rats to a 100% O2 environment.	Oxygen	96-98	superoxide dismutase 2	Rattus norvegicus	24-30
1938743-8	1991	The increased pulmonary Mn-SOD activity demonstrated in IL-1-insufflated rats at 2.3 days after O2 exposure may contribute to the protection against acute O2 toxicity, and the markedly increased activities of all pulmonary antioxidant enzymes shown in rats insufflated with IL-1 that survived O2 exposure for 7 days may in part be responsible for the chronic adaptation of these rats to a 100% O2 environment.	Oxygen	155-157	superoxide dismutase 2	Rattus norvegicus	24-30
1938743-8	1991	The increased pulmonary Mn-SOD activity demonstrated in IL-1-insufflated rats at 2.3 days after O2 exposure may contribute to the protection against acute O2 toxicity, and the markedly increased activities of all pulmonary antioxidant enzymes shown in rats insufflated with IL-1 that survived O2 exposure for 7 days may in part be responsible for the chronic adaptation of these rats to a 100% O2 environment.	Oxygen	155-157	superoxide dismutase 2	Rattus norvegicus	24-30
1938743-8	1991	The increased pulmonary Mn-SOD activity demonstrated in IL-1-insufflated rats at 2.3 days after O2 exposure may contribute to the protection against acute O2 toxicity, and the markedly increased activities of all pulmonary antioxidant enzymes shown in rats insufflated with IL-1 that survived O2 exposure for 7 days may in part be responsible for the chronic adaptation of these rats to a 100% O2 environment.	Oxygen	155-157	superoxide dismutase 2	Rattus norvegicus	24-30
1956583-2	1991	Incubation of brain slices under oxygen in artificial cerebrospinal fluid containing acrylamide produced a dose and time dependent inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH).	Oxygen	33-39	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	145-185
1956583-2	1991	Incubation of brain slices under oxygen in artificial cerebrospinal fluid containing acrylamide produced a dose and time dependent inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH).	Oxygen	33-39	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	187-192
2050145-0	1991	Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures.	Oxygen	14-20	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	65-98
2050145-2	1991	The activation of the PCK gene by glucagon was studied in primary rat hepatocyte cultures under physiological arterial and venous oxygen tensions [16% and 8% (by vol.)].	Oxygen	130-136	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	22-25
2050145-5	1991	Transcription of the PCK gene was increased by 10 nM glucagon maximally after 0.5 h; it reached nearly basal levels again after 2 h. The increase in transcription was 45% lower under 8% oxygen than under 16% oxygen.	Oxygen	186-192	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	21-24
2050145-5	1991	Transcription of the PCK gene was increased by 10 nM glucagon maximally after 0.5 h; it reached nearly basal levels again after 2 h. The increase in transcription was 45% lower under 8% oxygen than under 16% oxygen.	Oxygen	208-214	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	21-24
2050145-7	1991	PCK mRNA was maximally increased after 2 h under 16% oxygen and after 4 h under 8% oxygen; it subsequently declined to twice the basal values after 8 h. The maximal increase after 2 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	53-59	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-7	1991	PCK mRNA was maximally increased after 2 h under 16% oxygen and after 4 h under 8% oxygen; it subsequently declined to twice the basal values after 8 h. The maximal increase after 2 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	83-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-7	1991	PCK mRNA was maximally increased after 2 h under 16% oxygen and after 4 h under 8% oxygen; it subsequently declined to twice the basal values after 8 h. The maximal increase after 2 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	83-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-7	1991	PCK mRNA was maximally increased after 2 h under 16% oxygen and after 4 h under 8% oxygen; it subsequently declined to twice the basal values after 8 h. The maximal increase after 2 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	83-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-9	1991	PCK enzyme activity was maximally increased after 4-6 h. The maximal enhancement after 4 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	114-120	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-9	1991	PCK enzyme activity was maximally increased after 4-6 h. The maximal enhancement after 4 h was 50% lower under 8% oxygen than under 16% oxygen.	Oxygen	136-142	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-3
2050145-14	1991	The degradation of PCK protein was equal under both oxygen tensions.	Oxygen	52-58	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	19-22
2050145-15	1991	The results show that in cultured rat hepatocytes the induction of PCK gene expression is modulated by physiological concentrations of oxygen.	Oxygen	135-141	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	67-70
2050145-17	1991	The periportal to perivenous oxygen gradient could be the major factor responsible for the predominant expression of the PCK gene in the periportal zone.	Oxygen	29-35	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	121-124
1896252-11	1991	The low concentration of both CuZnSOD and MnSOD in the fetal lung tissues may contribute to the vulnerability to oxygen toxicity.	Oxygen	113-119	superoxide dismutase 2	Rattus norvegicus	42-47
2032970-10	1991	When breathing 80% He-20% O2, the fr shifted to 14 +/- 2 Hz, far,1 did not change (98 +/- 9 Hz), and far,2 increased to greater than 320 Hz.	Oxygen	26-28	fatty acyl-CoA reductase 2	Canis lupus familiaris	101-106
1960632-4	1991	Four RDS patients (4/36-11%) already weaned from the respirator, needed supplemental oxygen.	Oxygen	85-91	peripherin 2	Homo sapiens	5-8
2129243-1	1990	This study examines the hypotheses that (i) erythropoietin (the hormone responsible for red blood cell production) is higher in the fetus (at low PO2) than in the neonate (at high PO2); and (ii) that the level of erythropoietin in the neonate is influenced by the presence of high oxygen affinity haemoglobin.	Oxygen	281-287	erythropoietin	Ovis aries	44-58
2176270-3	1990	Purified rat h-FABP at 40 microM scavenged as much as 30% O2- and 85% OH.. On the other hand, when 2 nmol (4 microM) FABP were exposed to free radicals, the maximum oleate binding capacity as measured by Scatchard analysis was reduced only by 14% and 27% for O2- and OH., respectively.	Oxygen	58-60	fatty acid binding protein 2	Rattus norvegicus	15-19
2176270-3	1990	Purified rat h-FABP at 40 microM scavenged as much as 30% O2- and 85% OH.. On the other hand, when 2 nmol (4 microM) FABP were exposed to free radicals, the maximum oleate binding capacity as measured by Scatchard analysis was reduced only by 14% and 27% for O2- and OH., respectively.	Oxygen	259-261	fatty acid binding protein 2	Rattus norvegicus	15-19
18597258-0	1990	Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles.	Oxygen	29-35	linoleate 9S-lipoxygenase-4	Glycine max	49-61
2223838-1	1990	Salicylate hydroxylase from Pseudomonas putida (EC 1.14.13.1, salicylate, NADH:oxygen oxidoreductase) is an FAD-containing monooxygenase, which catalyzes decarboxylative hydroxylation of salicylate to produce catechol in the presence of NADH and O2.	Oxygen	246-248	salicylate hydroxylase	Pseudomonas putida	0-22
2203757-0	1990	Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli.	Oxygen	0-6	oxidoreductase	Escherichia coli	39-53
2122607-10	1990	Although purified NADPH-cytochrome P-450 reductase was also effective in reduction of mitomycin c and the concomitant reduction of O2, complete microsomal systems and fully reconstituted systems of cytochrome P-450b or P-450c and the reductase were much more efficient.	Oxygen	131-133	cytochrome p450 oxidoreductase	Rattus norvegicus	18-50
2379174-5	1990	Three of the four cases of adenomatous polyposis gave a positive reaction for glucose-6-phosphate dehydrogenase activity in oxygen in a manner similar to that of specimens with severe dysplasia.	Oxygen	124-130	glucose-6-phosphate dehydrogenase	Homo sapiens	78-111
2164917-10	1990	We conclude that small changes in O2 within the physiological range directly and specifically inhibit aldosteronogenesis in a dose-dependent manner with a P50 of approximately 95 torr.	Oxygen	34-36	secernin 1	Bos taurus	155-158
2384608-0	1990	Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.	Oxygen	0-6	platelet derived growth factor subunit B	Homo sapiens	47-85
2384608-5	1990	We found that hypoxic conditions (0-3% oxygen environments) significantly increased PDGF-B mRNA in cultured human umbilical vein endothelial cells by enhancing the transcriptional rate of this gene.	Oxygen	39-45	platelet derived growth factor subunit B	Homo sapiens	84-90
2384608-8	1990	These studies indicate that endothelial cells are not only capable of sensing oxygen tension, but are also able to discriminate and respond to even small differences in oxygen tension resulting in dramatic upregulation of the PDGF-B chain gene.	Oxygen	78-84	platelet derived growth factor subunit B	Homo sapiens	226-238
2384608-8	1990	These studies indicate that endothelial cells are not only capable of sensing oxygen tension, but are also able to discriminate and respond to even small differences in oxygen tension resulting in dramatic upregulation of the PDGF-B chain gene.	Oxygen	169-175	platelet derived growth factor subunit B	Homo sapiens	226-238
2191506-6	1990	Finally, C-11 acetate as a tracer of tricarboxylic acid cycle activity and myocardial oxygen consumption has been suggested for clinical use in initial studies in man.	Oxygen	86-92	RNA polymerase III subunit K	Homo sapiens	9-13
1689550-9	1990	We also show that in neonatal rabbits exposed to 100% oxygen for 96 h, the mRNAs corresponding to TIMP, SP-A, and another H-I gene are increased.	Oxygen	54-60	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	104-108
2096688-4	1990	Besides changes in hemodynamics, in our study a gradual decreased oxygen affinity of hemoglobin could be observed.	Oxygen	66-72	HGB	Sus scrofa	85-95
2210484-0	1990	[The role of cholecystokinin receptors in the regulation of the circulation and oxygen consumption in the pancreas].	Oxygen	80-86	cholecystokinin	Canis lupus familiaris	13-28
2210484-9	1990	These results suggest that the CCK receptors of the pancreas may be involved in the food-induced increases in the pancreatic blood flow, oxygen consumption and exocrine secretion.	Oxygen	137-143	cholecystokinin	Canis lupus familiaris	31-34
1964932-4	1990	Moreover, depletion of cellular glutathione peroxidase resulted in reduced synthesis of the lipoxygenase product 12-hydroxyeicosatetraenoic acid, as well as in reduce O2- thus establishing a link between O2- generation, the lipoxygenase pathway and the glutathione cycle.	Oxygen	167-169	glutathione peroxidase 1	Homo sapiens	23-54
1964932-4	1990	Moreover, depletion of cellular glutathione peroxidase resulted in reduced synthesis of the lipoxygenase product 12-hydroxyeicosatetraenoic acid, as well as in reduce O2- thus establishing a link between O2- generation, the lipoxygenase pathway and the glutathione cycle.	Oxygen	204-206	glutathione peroxidase 1	Homo sapiens	23-54
2250933-3	1990	Preretinal and transretinal PO2 measurements in ischemic territories following a laser occlusion of a retinal branch vein demonstrated that in normoxia the direction of PO2 gradients prevents O2 diffusing from the choroid to reach the inner retina.	Oxygen	29-31	PO2	Sus scrofa	169-172
2250933-5	1990	In the contrary, during hyperoxia the intraretinal PO2 gradient indicates an O2 flux from the choroid to the inner retina resulting to marked preretinal PO2 increase at the affected territories.	Oxygen	52-54	PO2	Sus scrofa	153-156
2191344-3	1990	Peripheral delivery of oxygen and induction of tissue hyperoxygenation with HOT may be verified by measurement of the TcPO2 under HOT.	Oxygen	23-29	alcohol dehydrogenase iron containing 1	Homo sapiens	130-133
33940052-5	2021	A detailed analysis of the mitochondrial metabolism revealed that miR-31* transfection increases basal oxygen consumption and spare respiratory capacity that leads to an increase in ATP production.	Oxygen	103-109	microRNA 31	Cricetulus griseus	66-72
33972558-0	2021	Spin-polarized oxygen evolution reaction under magnetic field.	Oxygen	15-21	spindlin 1	Homo sapiens	0-4
33972558-6	2021	We found that the spin polarization occurs at the first electron transfer step in OER, where coherent spin exchange happens between the ferromagnetic catalyst and the adsorbed oxygen species with fast kinetics, under the principle of spin angular momentum conservation.	Oxygen	176-182	spindlin 1	Homo sapiens	18-22
33972558-6	2021	We found that the spin polarization occurs at the first electron transfer step in OER, where coherent spin exchange happens between the ferromagnetic catalyst and the adsorbed oxygen species with fast kinetics, under the principle of spin angular momentum conservation.	Oxygen	176-182	spindlin 1	Homo sapiens	102-106
33972558-6	2021	We found that the spin polarization occurs at the first electron transfer step in OER, where coherent spin exchange happens between the ferromagnetic catalyst and the adsorbed oxygen species with fast kinetics, under the principle of spin angular momentum conservation.	Oxygen	176-182	spindlin 1	Homo sapiens	102-106
33972558-7	2021	In the next three electron transfer steps, as the adsorbed O species adopt fixed spin direction, the OER electrons need to follow the Hund rule and Pauling exclusion principle, thus to carry out spin polarization spontaneously and finally lead to the generation of triplet state O2.	Oxygen	279-281	spindlin 1	Homo sapiens	195-199
33972558-8	2021	Here, we showcase spin-polarized kinetics of oxygen evolution reaction, which gives references in the understanding and design of spin-dependent catalysts.	Oxygen	45-51	spindlin 1	Homo sapiens	18-22
33972558-8	2021	Here, we showcase spin-polarized kinetics of oxygen evolution reaction, which gives references in the understanding and design of spin-dependent catalysts.	Oxygen	45-51	spindlin 1	Homo sapiens	130-134
33811438-2	2022	Fan et al1 on evaluating the clinical efficacy of hyperbaric oxygen therapy (HBOT) as adjuvant therapy for hair transplantation surgery with great interest, including exploring the clinical effects of the integrated therapy of hair transplantation and HBOT.	Oxygen	61-67	ephrin A5	Homo sapiens	7-10
33808036-5	2021	Intracellular signaling and the production of reactive oxygen species are affected by extracellular TAGE and RAGE interactions, which, in turn, facilitate the intracellular generation of TAGE, all of which may contribute to the pathological changes observed in LSRD.	Oxygen	55-61	advanced glycosylation end-product specific receptor	Homo sapiens	109-113
33232689-13	2021	Furthermore, it is reasonable to consider that IS-promoted O2- production in the presence of vascular endothelium is through binding to AhR and the activation of NADPH oxidase.	Oxygen	59-62	aryl hydrocarbon receptor	Rattus norvegicus	136-139
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	81-83	hydroxyacid oxidase 1	Homo sapiens	4-7
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	81-83	hydroxyacid oxidase 1	Homo sapiens	21-24
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	81-83	hydroxyacid oxidase 1	Homo sapiens	21-24
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	4-7
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	21-24
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	21-24
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	4-7
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	21-24
33161703-7	2020	The GOx on the Pd@Pt-GOx could catalyze the oxidation of intratumoral glucose by O2 for cancer starvation therapy, while the O2 produced from the decomposition of endogenous H2O2 by the Pd@Pt with the CAT-like activity could accelerate the O2-dependent depletion of glucose by GOx.	Oxygen	125-127	hydroxyacid oxidase 1	Homo sapiens	21-24
33034314-5	2020	Once MONs-GOx@MnO2-Ce6 enter tumor cells, it catalyzes the oxidation of glucose using oxygen (O2) and generates hydrogen peroxide (H2O2) and gluconic acid, the former of which may accelerate the decomposition of MnO2 nanosheets.	Oxygen	86-92	hydroxyacid oxidase 1	Homo sapiens	10-13
33034314-5	2020	Once MONs-GOx@MnO2-Ce6 enter tumor cells, it catalyzes the oxidation of glucose using oxygen (O2) and generates hydrogen peroxide (H2O2) and gluconic acid, the former of which may accelerate the decomposition of MnO2 nanosheets.	Oxygen	16-18	hydroxyacid oxidase 1	Homo sapiens	10-13
29104026-7	2019	PLA2R1 was shown to induce activation of Janus-kinase 2 (JAK2) and estrogen-related receptor alpha (ERRalpha)-controlled mitochondrial proteins, as well as increasing the accumulation of reactive oxygen species, thus leading to apoptosis and senescence.	Oxygen	196-202	phospholipase A2 receptor 1	Homo sapiens	0-6
25420773-8	2014	Our findings reveal that PHD3 inactivation provides an alternative route of EGFR activation through which tumour cells sustain proliferative signalling even under conditions of limited oxygen availability.	Oxygen	185-191	egl-9 family hypoxia inducible factor 3	Homo sapiens	25-29
34879577-6	2022	OH,  O2- and 1O2 played important roles in the pollutant"s degradation, while the generation of  O2- was enhanced due to the floatability in this system.	Oxygen	97-100	immunoglobulin kappa variable 1D-39	Homo sapiens	5-16
34838423-2	2022	Experiments and ab initio calculations revealed that the 1,4-pentadien-3-ol monomer prefers a configuration with one vinyl being syn to the hydroxyl oxygen and the hydroxyl hydrogen toward the skew arranged vinyl, which therefore makes possible simultaneous CH   O and OH   pi interactions.	Oxygen	149-155	synemin	Homo sapiens	129-132
34748210-3	2022	The Handling Oxygenation Targets in the ICU (HOT-ICU) trial is a multicentre, randomised, parallel-group trial of a lower oxygenation target (arterial partial pressure of oxygen (PaO2 ) = 8 kPa) versus a higher oxygenation target (PaO2 = 12 kPa) in adult ICU patients with acute hypoxaemic respiratory failure.	Oxygen	171-177	alcohol dehydrogenase iron containing 1	Homo sapiens	45-48
34713936-8	2022	Our results implicate that inhibiting MAO-B activity has dual beneficial effects in preventing astrogliosis and scar-formation under brain injury, and that the MAO-B/H2 O2 pathway can be a useful therapeutic target with a high clinical potential.	Oxygen	169-171	monoamine oxidase B	Homo sapiens	38-43
34713936-8	2022	Our results implicate that inhibiting MAO-B activity has dual beneficial effects in preventing astrogliosis and scar-formation under brain injury, and that the MAO-B/H2 O2 pathway can be a useful therapeutic target with a high clinical potential.	Oxygen	169-171	monoamine oxidase B	Homo sapiens	160-165
34813109-11	2022	As expected, hypoxia (8% O2 - 3 hours) induced a robust increase in fos expression within the catecholaminergic C1 and A5 regions of the brainstem.	Oxygen	25-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
34941239-0	2022	Transition Metal and N Doping on AlP Monolayers for Bifunctional Oxygen Electrocatalysts: Density Functional Theory Study Assisted by Machine Learning Description.	Oxygen	65-71	ATHS	Homo sapiens	33-36
34941239-2	2022	Herein, we propose a single transition-metal (TM)-based defective AlP system to validate bifunctional oxygen electrocatalysis by using the density functional theory (DFT) method.	Oxygen	102-108	ATHS	Homo sapiens	66-69
34953386-3	2022	Herein, we successfully construct a radioactive nano-oxygen generator (177Lu-APPs-PEG) with superior properties, which can not only realize a high-performance radioisotope labelling, but also unfreeze the limitation of O2 dependence of internal radioisotope therapy (IRT).	Oxygen	53-59	cathepsin B	Homo sapiens	77-81
34953386-3	2022	Herein, we successfully construct a radioactive nano-oxygen generator (177Lu-APPs-PEG) with superior properties, which can not only realize a high-performance radioisotope labelling, but also unfreeze the limitation of O2 dependence of internal radioisotope therapy (IRT).	Oxygen	219-221	cathepsin B	Homo sapiens	77-81
34661743-0	2022	Regulatory role of miR-129 and miR-384-5p on apoptosis induced by oxygen and glucose deprivation in PC12 cell.	Oxygen	66-72	microRNA 384	Rattus norvegicus	31-38
34713523-2	2022	The composite (GOx&DhHP-6@ZIF-8) is then used to initiate oxygen-tolerant reversible addition-fragmentation chain-transfer (RAFT) polymerization for different methacrylate monomers, such as 2-diethylaminoethyl methacrylate, 2-hydroxyethyl methacrylate and poly (ethylene glycol) methyl ether methacrylate (Mn = 500 g mol-1 ).	Oxygen	58-64	hydroxyacid oxidase 1	Homo sapiens	15-18
34482636-6	2022	ATG13 S318 phosphorylation and autophagosome formation was dependent upon ATM, and activation of ATM was dependent on reactive oxygen species.	Oxygen	127-133	autophagy related 13	Homo sapiens	0-5
34973363-0	2022	Thioredoxin reductase 1 inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling.	Oxygen	97-103	thioredoxin reductase 1	Homo sapiens	0-23
34973363-4	2022	Besides, TrxR1 efficiently reduced shikonin in both selenocysteine dependent and selenocysteine independent manners, the oxygen-coupled redox cycling of shikonin also generates excessive superoxide anions.	Oxygen	121-127	thioredoxin reductase 1	Homo sapiens	9-14
34923096-12	2022	LyP-1 guides IR780 to target tumor cells for PDT with adequate O2 supply.	Oxygen	63-65	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	0-5
34812607-1	2021	The mitochondrial complex I (MC-I) of the electron transport chain (ETC) on the inner membrane is the electron entry point of the ETC and is essential for the production of reactive oxygen species.	Oxygen	182-188	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	4-33
34890296-0	2022	Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK- PGC1alpha Signaling and Limits Oxygen Toxicity.	Oxygen	97-103	thioredoxin 1	Mus musculus	0-11
34890296-8	2022	Treatment of cells with rhTrx or exposure of Trx-Tg mice prevented the loss of UCP2 protein and decreased O2 - generation in the lung.	Oxygen	106-108	thioredoxin 1	Mus musculus	45-48
34890296-11	2022	Trx activates MKK4-p38MAPK-PGC1alpha pathway leading to rescue of UCP2 and decreased O2 - generation in hyperoxia.	Oxygen	85-87	thioredoxin 1	Mus musculus	0-3
34943907-1	2021	Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral nervous systems and cerebrospinal fluid.	Oxygen	24-26	neuroglobin	Homo sapiens	0-11
34943907-1	2021	Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral nervous systems and cerebrospinal fluid.	Oxygen	24-26	neuroglobin	Homo sapiens	13-16
34943907-9	2021	Indeed, NGB overexpression enhances bioenergetic metabolism, increasing OCR and oxygen consumption.	Oxygen	80-86	neuroglobin	Homo sapiens	8-11
34310360-4	2021	Sodium nitrite is used mostly in the food industry (as a preservative) and in medical field (as an antidote to cyanide poisoning), and if ingested in large enough amounts, it can be fatal.The ingestion of sodium nitrite can cause severe methemoglobinemia, which is a metabolic disorder characterized by an inability of hemoglobin (which gets oxidized into methemoglobin) to bind (and therefore carry) oxygen.	Oxygen	401-407	hemoglobin subunit gamma 2	Homo sapiens	356-369
34747201-10	2021	In vitro, primary transgenic cardiomyocytes incubated overnight and thus exposed to abundantly secreted VEGFB isoforms in the absence of any in vivo confounding regulators of cardiac metabolism demonstrated higher basal oxygen consumption.	Oxygen	220-226	vascular endothelial growth factor B	Homo sapiens	104-109
34319516-6	2021	The optimal Hg0 removal temperature of the existing cobalt oxide catalysts was always around 150  C, but H2-TPR showed that the oxygen atoms on the Co3O4@C were more active than those on Co3O4, causing the Hg0 removal temperature window of Co3O4@C to shift to lower temperatures.	Oxygen	128-134	translocated promoter region, nuclear basket protein	Homo sapiens	108-111
34721681-7	2021	Culture of HA-VSMCs under hypoxic conditions (1% O2) reduced the expression of RP11-531A24.3, and enhanced the protein expression of ANXA2 and HIF-1alpha, while knockdown of ANXA2 downregulated the protein expression of HIF-1alpha.	Oxygen	49-51	pre-mRNA processing factor 31	Homo sapiens	79-83
34779611-3	2021	The correlation between the target-triggered formation of the DNA complexes and the catalytic reduction of the dissolved O2 makes possible the steady microRNA-10b detection with good sensitivity and selectivity.	Oxygen	121-123	microRNA 10b	Homo sapiens	150-162
34756042-2	2021	Chloride ions (Cl-) have been known as one of HbA allosteric effectors, which stabilizes the T-state preferable to release oxygen molecules.	Oxygen	123-129	keratin 90, pseudogene	Homo sapiens	46-49
34756042-10	2021	In conclusion, we theoretically certified that the effect of Cl- competes against that of solvated O2, i.e., the destabilization of T-state through the non-site-specific interaction, implying the concerted regulation of HbA under physiological conditions.	Oxygen	99-101	keratin 90, pseudogene	Homo sapiens	220-223
34884437-4	2021	In HL-60 cells, NAC activated NOX2 to produce superoxide (O2 -).	Oxygen	58-62	cytochrome b-245 beta chain	Homo sapiens	30-34
34627804-1	2021	The purpose of this study is to investigate the protective effect of dehydrocostuslactone (DHL) on PC12 cells injury induced by oxygen and glucose deprivation/reperfusion (OGD/R) and its possible mechanism on the PI3K/AKT/mTOR pathway.	Oxygen	128-134	mechanistic target of rapamycin kinase	Rattus norvegicus	222-226
34583519-18	2021	Further, we show that activation of PERK/eIF2alpha signaling reduces mitochondrial complex-derived reactive oxygen species and improves cardiac cell survival in response to I/R.	Oxygen	108-114	eukaryotic translation initiation factor 2A	Rattus norvegicus	41-50
34450214-0	2021	Rcf proteins and their differential specificity for respiratory chain complexes: A unique role for Rcf2 on oxygen sensitive supercomplexes?	Oxygen	107-113	Rcf2p	Saccharomyces cerevisiae S288C	99-103
34450214-11	2021	We therefore suggest an involvement of Rcf2 for adaption of the respiratory chain to altering oxygen levels.	Oxygen	94-100	Rcf2p	Saccharomyces cerevisiae S288C	39-43
34755471-8	2021	The early suppression of EBTs, which worsened arterial O2  saturation, and the generation of a paroxysmal generalized clonic-tonic activity, which provoked the transition from eupneic to gasping respiration, were the critical events causing sudden death in the Cx36KO mice.	Oxygen	55-57	gap junction protein, delta 2	Mus musculus	261-267
34560411-15	2021	In vitro analysis of thioredoxin 1 revealed a previously undescribed capacity of the enzyme to directly scavenge O2 -.	Oxygen	113-117	thioredoxin 1	Mus musculus	21-34
34757278-8	2021	Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation.	Oxygen	145-151	interleukin 17A	Homo sapiens	104-109
34733464-9	2021	Quantitative analysis validated the pattern of IH-induced upregulation in vascular endothelial growth factor (VEGF), placental growth factor-1 (PIGF1), Tumor necrosis factor alpha (TNFa), IL2, IL4, and IL10 when compared to AO and P. In summary, modulation of environmental oxygen alters both secretome concentration and composition.	Oxygen	274-280	interleukin 10	Homo sapiens	202-206
34777354-11	2021	Functional analysis of dengue-specific up-regulated DEGs showed enrichment of pathways for DNA replication and cell division whereas down-regulated DEGs were mainly associated with erythrocyte and myeloid cell homeostasis, reactive oxygen and peroxide metabolic processes.	Oxygen	232-238	delta 4-desaturase, sphingolipid 1	Homo sapiens	148-152
34661387-4	2021	LOX served as a catalyst for intracellular lactic acid exhaustion, and ATO led to mitochondrial dysfunction to decrease oxygen consumption.	Oxygen	120-126	lysyl oxidase	Homo sapiens	0-3
34977483-4	2021	In particular, vascular endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O2 delivery, have evolved adaptively in small mammals in hypoxic environments.	Oxygen	131-133	Epo	Heterocephalus glaber	61-75
34977483-4	2021	In particular, vascular endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O2 delivery, have evolved adaptively in small mammals in hypoxic environments.	Oxygen	131-133	Epo	Heterocephalus glaber	77-80
34553729-0	2021	A flowerlike FePt/MnO2/GOx-based cascade nanoreactor with sustainable O2 supply for synergistic starvation-chemodynamic anticancer therapy.	Oxygen	70-72	hydroxyacid oxidase 1	Homo sapiens	23-26
34553729-3	2021	In an acidic environment, intratumoral H2O2 could be decomposed to O2 to accelerate the consumption of glucose catalyzed by GOx to induce cancer starvation.	Oxygen	67-69	hydroxyacid oxidase 1	Homo sapiens	124-127
34553729-6	2021	Therefore, BGMFP could catalyze a cascade of intracellular biochemical reactions and optimize the unique properties of MnO2, GOx and FePt via mutual promotion of each other to realize O2 supply, chemodynamic therapy (CDT) and starvation therapy.	Oxygen	184-186	hydroxyacid oxidase 1	Homo sapiens	125-128
34667209-6	2021	Hypoxia (1% O2 compared to 8% O2) significantly reduced cytotrophoblast NR4A2 mRNA expression, but not placental explant NR4A2 expression.	Oxygen	12-14	nuclear receptor subfamily 4 group A member 2	Homo sapiens	72-77
34667209-6	2021	Hypoxia (1% O2 compared to 8% O2) significantly reduced cytotrophoblast NR4A2 mRNA expression, but not placental explant NR4A2 expression.	Oxygen	30-32	nuclear receptor subfamily 4 group A member 2	Homo sapiens	72-77
34585187-6	2021	The generated O2 was utilized by GOx in starvation therapy to consume glucose and produce H2O2 and gluconic acid.	Oxygen	14-16	hydroxyacid oxidase 1	Homo sapiens	33-36
34629337-3	2022	Arginase (ARG) is downstream of a ligand-bound TR and overexpression of ARG2 induces the production of reactive oxygen species and subsequent exacerbation of kidney ischemia/reperfusion (I/R) injury.	Oxygen	112-118	arginase type II	Mus musculus	72-76
34760423-1	2021	Methemoglobinemia is caused due to an increase in methemoglobin in the blood, impairing oxygen transfer to tissues.	Oxygen	88-94	hemoglobin subunit gamma 2	Homo sapiens	50-63
34265295-0	2021	In cardiac muscle cells, both adrenergic agonists and antagonists induce reactive oxygen species from NOX2 but mutually attenuate each other"s effects.	Oxygen	82-88	cytochrome b-245 beta chain	Homo sapiens	102-106
34265295-7	2021	NOX2 inhibitor gp91ds-tat blocked reactive oxygen species generation by both the agonists and the antagonists.	Oxygen	43-49	cytochrome b-245 beta chain	Homo sapiens	0-4
34679678-3	2021	CST/Met (-) depleted reduced and oxidized glutathione in hepatocyte-derived cells, increased prostaglandin-endoperoxide synthase 2 expression, and promoted reactive oxygen species accumulation and lipid peroxidation, as well as necrotic cell death.	Oxygen	165-171	cystatin 12, pseudogene	Homo sapiens	0-3
34544857-3	2021	IL-6 blockade repressed the proliferation and migration of TSC2-deficient cells and reduced oxygen consumption and extracellular acidification.	Oxygen	92-98	TSC complex subunit 2	Homo sapiens	59-63
34465083-6	2021	The results provide the following insights into the effects of the bridging unit (sulfur vs oxygen) and the dibenzo-annulation on the spin delocalization in the bridged triarylamine radical cations: (1) An effective decrease of the spin density on the nitrogen atom is observed for the sulfur bridge relative to the oxygen bridge; and (2) a moderate decrease of the spin density on the oxygen atom rather than the nitrogen atom is induced by the dibenzo-annulation.	Oxygen	92-98	spindlin 1	Homo sapiens	134-138
34465083-6	2021	The results provide the following insights into the effects of the bridging unit (sulfur vs oxygen) and the dibenzo-annulation on the spin delocalization in the bridged triarylamine radical cations: (1) An effective decrease of the spin density on the nitrogen atom is observed for the sulfur bridge relative to the oxygen bridge; and (2) a moderate decrease of the spin density on the oxygen atom rather than the nitrogen atom is induced by the dibenzo-annulation.	Oxygen	92-98	spindlin 1	Homo sapiens	232-236
34465083-6	2021	The results provide the following insights into the effects of the bridging unit (sulfur vs oxygen) and the dibenzo-annulation on the spin delocalization in the bridged triarylamine radical cations: (1) An effective decrease of the spin density on the nitrogen atom is observed for the sulfur bridge relative to the oxygen bridge; and (2) a moderate decrease of the spin density on the oxygen atom rather than the nitrogen atom is induced by the dibenzo-annulation.	Oxygen	92-98	spindlin 1	Homo sapiens	366-370
34111396-7	2021	Treatment with adiponectin or pioglitazone alone showed improvements in metabolic indices, antioxidant enzymes, and abrogated arterial stiffness, attenuated generation of reactive oxygen species and dyslipidaemic effects of streptozotocin better as compared to irbesartan sets of treatment (all P<0.05).	Oxygen	180-186	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	15-26
34572575-2	2021	Glucose oxidase (GOx), which is considered as an attractive starvation reagent for cancer therapy, can effectively catalyze the conversion of glucose into gluconic acid and hydrogen peroxide (H2O2) in the presence of O2.	Oxygen	217-219	hydroxyacid oxidase 1	Homo sapiens	0-15
34572575-2	2021	Glucose oxidase (GOx), which is considered as an attractive starvation reagent for cancer therapy, can effectively catalyze the conversion of glucose into gluconic acid and hydrogen peroxide (H2O2) in the presence of O2.	Oxygen	217-219	hydroxyacid oxidase 1	Homo sapiens	17-20
34577609-7	2021	Importantly, we find that inhibition of TRPA1 prevents loss of CAPs during oxygen and glucose deprivation (OGD) and improves the recovery.	Oxygen	75-81	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	40-45
34502486-6	2021	Using mouse models of laser-induced choroidal neovascularization (CNV) and oxygen-induced retinopathy (OIR), our study demonstrated an increase in CFB expression during pathological angiogenesis.	Oxygen	75-81	complement factor B	Mus musculus	147-150
34659532-14	2021	Finally, we found that DDIT4 gene expression was significantly increased in the hypoxic environment compared to the normal oxygen environment, indicating that the DDIT4 gene may play an important role in the hypoxic microenvironment of tumor tissue.	Oxygen	123-129	DNA damage inducible transcript 4	Homo sapiens	23-28
34659532-14	2021	Finally, we found that DDIT4 gene expression was significantly increased in the hypoxic environment compared to the normal oxygen environment, indicating that the DDIT4 gene may play an important role in the hypoxic microenvironment of tumor tissue.	Oxygen	123-129	DNA damage inducible transcript 4	Homo sapiens	163-168
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	13-15	lysyl oxidase	Homo sapiens	64-67
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	13-15	lysyl oxidase	Homo sapiens	318-321
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	419-421	lysyl oxidase	Homo sapiens	64-67
34475406-3	2021	Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2.	Oxygen	419-421	lysyl oxidase	Homo sapiens	318-321
34101958-1	2021	Coupled dinuclear copper oxygen cores (Cu 2 O 2 ) featured in type III copper proteins (e.g. hemocyanin, tyrosinase, catechol oxidase) are vital for O 2 transport and substrate oxidation in a range of organisms.	Oxygen	25-31	tyrosinase	Homo sapiens	105-115
34153849-0	2021	Glucose oxidase loaded Cu2+ based metal-organic framework for glutathione depletion/reactive oxygen species elevation enhanced chemotherapy.	Oxygen	93-99	hydroxyacid oxidase 1	Homo sapiens	0-15
34146386-3	2021	Neuroglobin (Ngb) is a protein found in neurons of both the peripheral and central nervous system that appears to convey some resilience to hypoxia, while the hypoxia-inducible factor (Hif-1alpha) is a dimeric protein complex that plays an integral role in the body"s response to low oxygen concentrations, or hypoxia.	Oxygen	284-290	neuroglobin	Homo sapiens	0-11
34146386-3	2021	Neuroglobin (Ngb) is a protein found in neurons of both the peripheral and central nervous system that appears to convey some resilience to hypoxia, while the hypoxia-inducible factor (Hif-1alpha) is a dimeric protein complex that plays an integral role in the body"s response to low oxygen concentrations, or hypoxia.	Oxygen	284-290	neuroglobin	Homo sapiens	13-16
34146386-11	2021	Both Ngb and Hif-1alpha participate in oxygen transports throughout the telencephalon and have functions in neuroprotection.	Oxygen	39-45	neuroglobin	Homo sapiens	5-8
34440934-8	2021	Chondrogenesis at 2% O2 significantly reduced ALP gene expression and reduced type I collagen deposition, producing a more stable and less hypertrophic chondrogenic phenotype.	Oxygen	21-23	ATHS	Homo sapiens	46-49
34440934-9	2021	An O2 tension of 2% did not inhibit osteogenic differentiation at the protein level but reduced ALP and OC gene expression.	Oxygen	3-5	ATHS	Homo sapiens	96-99
34440934-10	2021	An upregulation of ALP and OC occurred during osteogenesis in BMP2 containing media under 20% O2; BMP2 free osteogenic media downregulated ALP and also led to higher sGAG release.	Oxygen	94-96	ATHS	Homo sapiens	19-22
34102281-5	2021	Genetic overexpression or therapeutic activation of Sirt1 efficiently ameliorated renal IR injury by elevating anti-oxidative genes expression and reducing the accumulation of reactive oxygen species, including O2 - and  OH.	Oxygen	211-215	sirtuin 1	Homo sapiens	52-57
34102281-6	2021	In addition, inhibition of G9a activity by BIX01294 (BIX) alleviated IR injury through abolishing O2 - and  OH levels in a Sirt1-dependent manner.	Oxygen	98-100	euchromatic histone lysine methyltransferase 2	Homo sapiens	27-30
34102281-6	2021	In addition, inhibition of G9a activity by BIX01294 (BIX) alleviated IR injury through abolishing O2 - and  OH levels in a Sirt1-dependent manner.	Oxygen	98-100	sirtuin 1	Homo sapiens	123-128
34102281-10	2021	In this study, we provided strong evidence that G9a modulated renal IR injury through cooperation with CBX1 to form a transcription repressor complex on the Sirt1 promoter and regulate O2 - and  OH generation, indicating that G9a-Sirt1 axis might be a promising therapeutic target in an epigenetic manner.	Oxygen	185-187	euchromatic histone lysine methyltransferase 2	Homo sapiens	48-51
34102281-10	2021	In this study, we provided strong evidence that G9a modulated renal IR injury through cooperation with CBX1 to form a transcription repressor complex on the Sirt1 promoter and regulate O2 - and  OH generation, indicating that G9a-Sirt1 axis might be a promising therapeutic target in an epigenetic manner.	Oxygen	185-187	chromobox 1	Homo sapiens	103-107
34320407-1	2021	In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens.	Oxygen	157-163	cytochrome b-245 beta chain	Homo sapiens	132-136
34436075-2	2021	Here, we studied the effect of DNA adsorption on electrochemical charge transfer at few-layered, oxygen-functionalized graphene (GOx) electrodes.	Oxygen	97-103	hydroxyacid oxidase 1	Homo sapiens	129-132
34212722-2	2021	Here, for the first time, atomically dispersed Co atoms are synthesized as biomimetic "enzymes" to monitor superoxide anions (O2 -), delivering ultraordinary high sensitivity (710.03 muA muM-1 cm-2), low detection limit (1.5 nM), and rapid response time (1.2 s), ranking the best among all the reported either bioenzymatic or biomimetic O2 - biosensors.	Oxygen	126-130	PWWP domain containing 3A, DNA repair factor	Homo sapiens	187-192
34353810-0	2021	Covid-19: CPAP reduces need for invasive mechanical ventilation in patients requiring oxygen, study finds.	Oxygen	86-92	centromere protein J	Homo sapiens	10-14
34280904-0	2021	Oxygen vacancy-rich 2D/0D BiO1-XBr/AgBr Z-scheme photocatalysts for efficient visible light driven degradation of tetracycline.	Oxygen	0-6	RE1 silencing transcription factor	Homo sapiens	31-34
34119887-5	2021	Herein, using glucose oxidase (GOx) as an O2-consuming agent to exacerbate hypoxia, a cascade strategy of GOx-induced overexpression of NTR and amplified NTR-catalyzed release was proposed for early antitumor therapy.	Oxygen	42-44	hydroxyacid oxidase 1	Homo sapiens	14-29
34119887-5	2021	Herein, using glucose oxidase (GOx) as an O2-consuming agent to exacerbate hypoxia, a cascade strategy of GOx-induced overexpression of NTR and amplified NTR-catalyzed release was proposed for early antitumor therapy.	Oxygen	42-44	hydroxyacid oxidase 1	Homo sapiens	31-34
34119887-5	2021	Herein, using glucose oxidase (GOx) as an O2-consuming agent to exacerbate hypoxia, a cascade strategy of GOx-induced overexpression of NTR and amplified NTR-catalyzed release was proposed for early antitumor therapy.	Oxygen	42-44	hydroxyacid oxidase 1	Homo sapiens	106-109
34119887-8	2021	First, as a "key", tumor hypoxia triggers the initial release of GOx, which serves as the O2-consuming agent when catalyzing its reaction with glucose, which is accompanied by H2O2 production.	Oxygen	90-92	hydroxyacid oxidase 1	Homo sapiens	65-68
34175561-3	2021	Based on Fenton reactions initiated by iron ions, CaO2-supplied H2O2 could not only generate  OH for H2O2-sufficient CDT, but also produce O2 to promote the catalytic efficiency of GOx under hypoxia.	Oxygen	139-141	hydroxyacid oxidase 1	Homo sapiens	181-184
34254504-4	2021	In the present study, reverse transcription-quantitative PCR demonstrated that XIST expression was upregulated in the brain tissues of an I/R mouse model and in oxygen and glucose deprivation/reperfusion (OGD/R)-treated Neuro-2a (N2a) cells.	Oxygen	161-167	inactive X specific transcripts	Mus musculus	79-83
34214783-2	2021	Chondrocytes, isolated from articular cartilage from the knee, hip, and shoulder joints of Wistar rats, were subjected to 20 % tensile stress under hypoxic (5% O2) conditions for 24 h. HIF-1alpha and aggrecan expression was significantly enhanced with mechanical stimulation under hypoxia but not significantly altered with mechanical stimulation under normoxia.	Oxygen	160-162	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	185-195
34267521-0	2021	Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through Regulation of the TLR4/MyD88/NF-kappaB Pathway.	Oxygen	66-72	TNFAIP3 interacting protein 2	Mus musculus	28-57
34267521-0	2021	Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through Regulation of the TLR4/MyD88/NF-kappaB Pathway.	Oxygen	66-72	myeloid differentiation primary response gene 88	Mus musculus	192-197
34239867-5	2020	Furthermore, downregulating SPCA1 with siRNA transfection aggravated UVA-induced senescence due to an elevation of intracellular calcium concentrations and a subsequent increase in reactive oxygen species (ROS) and MAPK activity.	Oxygen	190-196	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	28-33
34138843-3	2021	Recent studies revealed that signaling through the erythrocyte adenosine A2B receptor (ADORA2B) promotes O2 release to counteract hypoxia at high altitude.	Oxygen	105-107	adenosine A2b receptor	Mus musculus	87-94
34138843-8	2021	Mechanistically, erythrocyte ADORA2B-mediated activation of AMP-activated protein kinase (AMPK) and bisphosphoglycerate mutase (BPGM) promotes hypoxic and metabolic reprogramming to enhance production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific metabolite triggering O2 delivery.	Oxygen	285-287	adenosine A2b receptor	Mus musculus	29-36
34138843-8	2021	Mechanistically, erythrocyte ADORA2B-mediated activation of AMP-activated protein kinase (AMPK) and bisphosphoglycerate mutase (BPGM) promotes hypoxic and metabolic reprogramming to enhance production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific metabolite triggering O2 delivery.	Oxygen	285-287	2,3-bisphosphoglycerate mutase	Mus musculus	100-126
34138843-8	2021	Mechanistically, erythrocyte ADORA2B-mediated activation of AMP-activated protein kinase (AMPK) and bisphosphoglycerate mutase (BPGM) promotes hypoxic and metabolic reprogramming to enhance production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific metabolite triggering O2 delivery.	Oxygen	285-287	2,3-bisphosphoglycerate mutase	Mus musculus	128-132
34235304-4	2021	To compensate for this declination, in this study, a simultaneous generation of power and syngas (CO and H2) was proposed in an integrated NG-oxygen-fired gas turbine unit (GTU).	Oxygen	142-148	relaxin 2	Homo sapiens	98-107
34088899-1	2021	Inhibition of RhoA-ROCK pathway is involved in the H2S-induced cerebral vasodilatation and H2S-mediated protection on endothelial cells against oxygen-glucose deprivation/reoxygenation injury.	Oxygen	144-150	ras homolog family member A	Rattus norvegicus	14-18
34140895-3	2021	The purpose of this study was to determine if normobaric oxygen (NBO) might effectively induce HSP32 while concurrently inhibiting MEK1/2 and to observe any protective effects on spinal cord injury in DCS rats.	Oxygen	57-63	heme oxygenase 1	Rattus norvegicus	95-100
34205973-4	2021	The oxidative stress inducer paraquat (PQ) triggering formation of O2 - (and consequently, H2O2) was able to rescue the gravitropic response of Atcrk5-1 roots.	Oxygen	67-71	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	144-150
34073032-0	2021	Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts.	Oxygen	109-115	C-X-C motif chemokine ligand 11	Homo sapiens	70-77
34095615-3	2021	Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation.	Oxygen	125-131	hydroxyacid oxidase 1	Homo sapiens	214-217
34095615-3	2021	Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation.	Oxygen	133-135	hydroxyacid oxidase 1	Homo sapiens	214-217
34095615-3	2021	Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H2O2) into oxygen (O2), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation.	Oxygen	272-274	hydroxyacid oxidase 1	Homo sapiens	214-217
34065867-8	2021	The acinus and portal vessel locations in the lobule were found to be the most beneficial to tumor growth based on tumor access to blood flow and intratumoral oxygen.	Oxygen	159-165	apoptotic chromatin condensation inducer 1	Mus musculus	4-10
34068760-7	2021	O2- production was measured by superoxide dismutase-inhibitable reduction of cytochrome C. P47phox phosphorylation was analyzed by Western blot using specific antibodies against Ser328 and Ser345 sites.	Oxygen	0-3	neutrophil cytosolic factor 1	Homo sapiens	91-98
34063270-8	2021	We used gelatin methacryloyl (GelMA) hydrogels containing these OMPs to stimulate survival and proliferation of encapsulated skeletal myoblasts and optimized the OMP concentration for sustained oxygen delivery over more than a week.	Oxygen	194-200	olfactory marker protein	Homo sapiens	162-165
34137233-3	2021	In Alzheimer"s disease, TRPM2 is activated by reactive oxygen species generated by beta-amyloid peptide to form a malignant positive feedback loop that induces neuronal death and is involved in the pathological process of glial cells by promoting inflammatory response and oxidative stress.	Oxygen	55-61	transient receptor potential cation channel subfamily M member 2	Homo sapiens	24-29
35191606-1	2022	A bovine hemoglobin (HbBv) or human adult hemoglobin (HbA) wrapped covalently by human serum albumins (HSAs), hemoglobin-albumin clusters (HbBv-HSA3 and HbA-HSA3 ), are artificial O2 carriers used as a red blood cell substitute.	Oxygen	180-182	keratin 90, pseudogene	Homo sapiens	54-57
35364046-7	2022	Ngb is involved in cellular oxygen homeostasis and reactive oxygen/nitrogen scavenging in the central and peripheral nervous systems, but its functions in schistosome parasites have not yet been characterized.	Oxygen	28-34	neuroglobin	Homo sapiens	0-3
35364046-7	2022	Ngb is involved in cellular oxygen homeostasis and reactive oxygen/nitrogen scavenging in the central and peripheral nervous systems, but its functions in schistosome parasites have not yet been characterized.	Oxygen	60-66	neuroglobin	Homo sapiens	0-3
35580473-5	2022	The resultant GOx exposure initiates intratumoral glucose depletion, which is promoted by the O2 replenishment through Pt-catalyzed decomposition of H2O2.	Oxygen	94-96	hydroxyacid oxidase 1	Homo sapiens	14-17
35240166-7	2022	The quenching experiments indicated that both non-radical pathway (1O2) and radical pathway (OH, O2-) led to CIP degradation, in which O2- and 1O2 made major contribution.	Oxygen	97-100	immunoglobulin kappa variable 1D-39	Homo sapiens	135-146
35597499-11	2022	The direct target ABL1 is located upstream of Nrf2 and mTOR, Nrf2 can influence the expression of mTOR by affecting the level of reactive oxygen species.	Oxygen	138-144	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-22
35523948-0	2022	Correction: PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production.	Oxygen	106-112	polo like kinase 1	Homo sapiens	12-16
35460208-1	2022	Here, a strategy to regulate the electron density distribution by integrating NiFe layered double hydroxides (NiFe-LDH) nanosheets with Co3 O4 nanowires to construct the NiFe-LDH/Co3 O4 p-n heterojunction supported on nickel foam (NiFe-LDH/Co3 O4 /NF) for electrocatalytic oxygen evolution reaction (OER) is proposed.	Oxygen	273-279	neurofascin	Homo sapiens	248-250
35578899-3	2022	However, lactate depletion by lactate oxidase (LOX) consumes oxygen and results in the aggravated hypoxia situation, counteracting the benefit of lactate depletion.	Oxygen	61-67	lysyl oxidase	Homo sapiens	47-50
35634326-7	2022	Hypoxia (5% oxygen) increased the expression of EGFR, CXCR4, CTGF, and HIF-1alpha, the number and differentiation in fibrocytes.	Oxygen	12-18	C-X-C motif chemokine receptor 4	Homo sapiens	54-59
35505126-2	2022	The fabricated NixSy@MnOxHy/NF shows outstanding bifunctional activity and stability for hydrogen evolution reaction and oxygen evolution reaction, as well as overall-water-splitting performance.	Oxygen	121-127	neurofascin	Homo sapiens	28-30
35446020-3	2022	Coordination sites and O2 activation by complex 2 resemble the formylglycine generating enzyme (FGE), an enzyme recently crystallographically characterized with sulfur-only coordination around Cu (three thiolate ligands).	Oxygen	23-25	sulfatase modifying factor 1	Homo sapiens	96-99
35315130-5	2022	Crucially, the large energetic overlap between Cu 3d and O 2p states dictates the rigidity of oxygen framework, which effectively mitigates the structural distortion of local oxygen environment upon (de)sodiation and leads to the enhanced lattice OR reversibility.	Oxygen	94-100	immunoglobulin kappa variable 1D-39	Homo sapiens	57-61
35315130-5	2022	Crucially, the large energetic overlap between Cu 3d and O 2p states dictates the rigidity of oxygen framework, which effectively mitigates the structural distortion of local oxygen environment upon (de)sodiation and leads to the enhanced lattice OR reversibility.	Oxygen	175-181	immunoglobulin kappa variable 1D-39	Homo sapiens	57-61
35405266-7	2022	The MuSCs of IUGR newborns activate the Nrf2/SIRT1/PGC1alpha network by taking in DMG-Na, thereby neutralizing excessive generated O2 - that may help to improve their unfavorable mitochondrial dysfunction in skeletal muscle.	Oxygen	131-135	sirtuin 1	Homo sapiens	45-50
35490410-3	2022	Herein, an all-solid-state Na-O2 battery based on a well-designed NASICON-type electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 , which has high ionic conductivity (2.39 x 10-3 S cm-1 ) and excellent chemical stability, is developed.	Oxygen	30-32	X-C motif chemokine ligand 1	Homo sapiens	173-179
35629800-3	2022	The pilot test results demonstrated the remarkable performance of the combined sequential batch reactor (SBR) and C-MBR process, wherein the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) removal rates reached 93% and 98.9%, respectively.	Oxygen	150-156	translocator protein	Homo sapiens	116-119
35354123-5	2022	For metal-support interactions, surface spin polarization enhances the bonding between Pt nanoparticles and ceria surface oxygen, while CO adsorption on Pt nanoparticles weakens the interfacial interaction regardless of spin polarization.	Oxygen	122-128	spindlin 1	Homo sapiens	40-44
35081462-1	2022	This study evaluated the greenhouse gas emissions of solid dairy manure storage with the micro-aerobic group (MA; oxygen concentration <5%) and control group (CK; oxygen concentration <1%), and explained the difference in greenhouse gas emissions by exploring bacterial community succession.	Oxygen	163-169	cytidine/uridine monophosphate kinase 1	Homo sapiens	159-161
35081462-2	2022	The results showed that the MA remained the micro-aerobic conditions, which the maximum and average oxygen concentrations were 4.1% and 1.9%, respectively; while the average oxygen concentrations of the CK without intervention management was 0.5%.	Oxygen	174-180	cytidine/uridine monophosphate kinase 1	Homo sapiens	203-205
35296453-7	2022	The lead inhibitor interacted with FAAH and MAGL via pi-pi stacking via phenyl ring and hydrogen bonding through sulfonyl oxygen atoms or amide NH.	Oxygen	122-128	monoglyceride lipase	Homo sapiens	44-48
35182555-0	2022	Hyperbaric oxygen therapy improves age induced bone dyshomeostasis in non-obese and obese conditions.	Oxygen	11-17	renin binding protein	Rattus norvegicus	35-38
35410638-0	2022	AURKB, in concert with REST, acts as an oxygen-sensitive epigenetic regulator of the hypoxic induction of MDM2.	Oxygen	40-46	aurora kinase B	Homo sapiens	0-5
35410638-0	2022	AURKB, in concert with REST, acts as an oxygen-sensitive epigenetic regulator of the hypoxic induction of MDM2.	Oxygen	40-46	MDM2 proto-oncogene	Homo sapiens	106-110
35410638-9	2022	In this study, we present a case of hypoxia-specific epigenetic regulation of the oxygen-sensitive AURKB signaling pathway.	Oxygen	82-88	aurora kinase B	Homo sapiens	99-104
35143076-8	2022	Both in vitro and in vivo results demonstrate that PBzyme reduces the activation of microglial NLRP3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating GSDMD cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis.	Oxygen	152-158	gasdermin D	Mus musculus	191-196
35236105-6	2022	In accordance with these observations, global knockdown of PLCbeta3 or endothelial cell-specific deletion of NFATc1 or siRNA-mediated depletion of CDC6 levels substantially inhibited oxygen-induced retinopathy-induced retinal sprouting and neovascularization.	Oxygen	183-189	cell division cycle 6	Mus musculus	147-151
35236105-7	2022	In addition, retroviral-mediated overexpression of CDC6 rescued oxygen-induced retinopathy-induced retinal neovascularization from inhibition in PLCbeta3 knockout mice and in endothelial cell-specific NFATc1-deficient mice.	Oxygen	64-70	cell division cycle 6	Mus musculus	51-55
35236105-8	2022	CONCLUSIONS: The above observations clearly reveal that PLCbeta3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.	Oxygen	148-154	cell division cycle 6	Mus musculus	102-106
35236105-8	2022	CONCLUSIONS: The above observations clearly reveal that PLCbeta3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.	Oxygen	148-154	vascular endothelial growth factor A	Mus musculus	142-147
34995622-3	2022	Herein, Cu-coupled Fe/Fe3C covered with carbon layer on carbon felt (Cu-Fe/Fe3C@C), engineered by a hydrothermal reaction followed by the consequent thermal-treatment in N2 atmosphere, as a self-supported integrated cathode were used for an onsite oxygen reduction reaction and a Fenton oxidation reaction.	Oxygen	248-254	general transcription factor IIE subunit 1	Homo sapiens	19-21
34995622-3	2022	Herein, Cu-coupled Fe/Fe3C covered with carbon layer on carbon felt (Cu-Fe/Fe3C@C), engineered by a hydrothermal reaction followed by the consequent thermal-treatment in N2 atmosphere, as a self-supported integrated cathode were used for an onsite oxygen reduction reaction and a Fenton oxidation reaction.	Oxygen	248-254	general transcription factor IIE subunit 1	Homo sapiens	72-74
35181144-14	2022	Furthermore, compared with control and fatty acids, reactive oxygen species concentrations in the DGAT1 inhibitor with or without fatty acid group was greater.	Oxygen	61-67	diacylglycerol O-acyltransferase 1	Bos taurus	98-103
35459481-4	2022	By carefully heating the triplet carbene CF3CH in an O2-doped Ar-matrix to 35 K, the elusive carbonyl oxide CF3C(H)OO in syn- and anti-conformations has been generated and characterized with infrared (IR) and ultraviolet-visible (UV-vis) spectroscopy.	Oxygen	53-55	synemin	Homo sapiens	121-124
35433667-8	2022	The maximum ethanol titer of the four strains (KZ (BG-cwp2), KZ (BG), WZ (BG-cwp2), and WZ (BG)) in oxygen-limited 10% cellobiose fermentation was 3.173, 5.307, 5.495, and 5.486% (v/v), respectively, and the acetic acid titer ranged from 0.038 to 0.060% (v/v).	Oxygen	100-106	Cwp2p	Saccharomyces cerevisiae S288C	54-58
35433667-8	2022	The maximum ethanol titer of the four strains (KZ (BG-cwp2), KZ (BG), WZ (BG-cwp2), and WZ (BG)) in oxygen-limited 10% cellobiose fermentation was 3.173, 5.307, 5.495, and 5.486% (v/v), respectively, and the acetic acid titer ranged from 0.038 to 0.060% (v/v).	Oxygen	100-106	Cwp2p	Saccharomyces cerevisiae S288C	77-81
35327664-3	2022	Glucose oxidase catalyzes the oxidation of beta-d-glucose to d-glucono-delta-lactone and hydrogen peroxide in the presence of molecular oxygen.	Oxygen	136-142	hydroxyacid oxidase 1	Homo sapiens	0-15
35327505-9	2022	Functional metabolic analysis demonstrated that CD5KO T cells have higher oxygen consumption rates (OCR) and higher extracellular acidification rates (ECAR).	Oxygen	74-80	CD5 antigen	Mus musculus	48-51
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Oxygen	28-34	NAD(P)H dehydrogenase, quinone 1	Mus musculus	14-18
35212342-3	2022	Therein, we observed two deuteron quadrupole coupling constant for the ND bond of the TEA cation, indicating differently strong hydrogen bonds to the nitrogen and oxygen atoms of the NTf2 anion, as we could confirm by DFT calculations.	Oxygen	163-169	nuclear transport factor 2	Homo sapiens	183-187
35246033-0	2022	Correction to: Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.	Oxygen	26-32	Wnt family member 10A	Rattus norvegicus	122-129
34995401-10	2022	Moreover, SESN2 ablation significantly attenuated the exercise-promoted respiratory exchange ratio and indexes of energy metabolism (oxygen uptake and energy expenditure).	Oxygen	133-139	sestrin 2	Mus musculus	10-15
35243823-5	2022	Experimentally, a series of characterization results confirm the reconstruction behavior in the Ni3 S2 /Fe-NiPx surface, leading to the in situ formation of Ni(OH)2 /Ni(Fe)OOH with abundant oxygen vacancies and grain boundaries, which constructs the Ni3 S2 /Fe-NiPx reconstruction system responsible for the remarkable OER catalytic activity.	Oxygen	190-196	general transcription factor IIE subunit 1	Homo sapiens	104-106
35243823-5	2022	Experimentally, a series of characterization results confirm the reconstruction behavior in the Ni3 S2 /Fe-NiPx surface, leading to the in situ formation of Ni(OH)2 /Ni(Fe)OOH with abundant oxygen vacancies and grain boundaries, which constructs the Ni3 S2 /Fe-NiPx reconstruction system responsible for the remarkable OER catalytic activity.	Oxygen	190-196	general transcription factor IIE subunit 1	Homo sapiens	169-171
35236967-0	2022	PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production.	Oxygen	94-100	polo like kinase 1	Homo sapiens	0-4
35236967-8	2022	Inhibition of PLK1 in ARID1A KO cells further uncouples oxygen consumption from ATP production, with subsequent membrane depolarization and apoptosis.	Oxygen	56-62	polo like kinase 1	Homo sapiens	14-18
35424690-1	2022	In order to develop a liquid oxygen-compatible (LOX-compatible) matrix resins for polymer-based fiber-reinforced composites, a novel phosphorus-containing imidazole derivative called VAD containing multifunctional groups was synthesized and used as a co-curing agent for epoxy resin (EP) with simultaneous LOX-compatibility and mechanical improvement.	Oxygen	29-35	lysyl oxidase	Homo sapiens	48-51
35133813-5	2022	The introduction of La3+ can regulate the crystal field splitting strength of the Eu2+ activators, causing redshifts in the emission spectrum while increasing Ga3+ content will lead to enhanced energy transfer between the oxygen vacancy and Eu2+, as well as improved thermal stability.	Oxygen	222-228	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	159-162
35190584-2	2022	Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO2peak) in BRCA1/2 mutation carriers whose risk of developing BC is high.	Oxygen	72-78	BRCA1 DNA repair associated	Homo sapiens	99-106
35171971-0	2022	Scalable manufacturing platform for the production of methemoglobin as a non-oxygen carrying control material in studies of cell-free hemoglobin solutions.	Oxygen	77-83	hemoglobin subunit gamma 2	Homo sapiens	54-67
35171971-1	2022	Methemoglobin (metHb) arises from the oxidation of ferrous hemoglobin (HbFe2+, Hb) to ferric hemoglobin (HbFe3+, metHb), which is unable to bind gaseous ligands such as oxygen (O2) and carbon monoxide (CO), and binds to nitric oxide (NO) significantly slower compared to Hb.	Oxygen	169-175	hemoglobin subunit gamma 2	Homo sapiens	0-13
35171971-1	2022	Methemoglobin (metHb) arises from the oxidation of ferrous hemoglobin (HbFe2+, Hb) to ferric hemoglobin (HbFe3+, metHb), which is unable to bind gaseous ligands such as oxygen (O2) and carbon monoxide (CO), and binds to nitric oxide (NO) significantly slower compared to Hb.	Oxygen	177-179	hemoglobin subunit gamma 2	Homo sapiens	0-13
35165707-7	2022	Mechanistic studies using the Dectin-1 inhibitor, laminarin, and Dectin-1-/- mice revealed that Galectin-3 bound to and activated Dectin-1, a receptor not previously reported in platelets, to phosphorylate spleen tyrosine kinase and thus increased Ca2+ influx, protein kinase C activation, and reactive oxygen species production to regulate platelet hyperreactivity.	Oxygen	303-309	C-type lectin domain family 7, member a	Mus musculus	130-138
35211629-6	2022	Additionally, BPTES downregulated the extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) values of activated CD4+ T cells from SS mice.	Oxygen	82-88	CD4 antigen	Mus musculus	132-135
35163179-12	2022	Consistently, compared with Col-0, the O2- and MDA contents in the TCH4 overexpression lines increased under B-deficient conditions.	Oxygen	39-41	Xyloglucan endotransglucosylase/hydrolase family protein	Arabidopsis thaliana	67-71
34967264-7	2022	SOX2-OT knockdown attenuated oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cardiomyocyte dysregulation through relieving inflammation, promoting proliferation, and reducing apoptosis in OGD/R-treated H2C9 cells.	Oxygen	29-35	SOX2 overlapping transcript	Homo sapiens	0-7
34976166-9	2022	The cells cultured in 1% O2 highly expressed CD133 and CD15 and had a lower apoptosis rate.	Oxygen	25-27	prominin 1	Mus musculus	45-50